bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distal Radius Fracture Outcomes After Dorsal Spanning Plate Fixation
Authors: DeFazio Matthew W. , Godfrey Natalie , Offord Evan , Budis Emmanuel , Olson Nathanael , Jones Marci 
Published: April 2023

Background: Dorsal spanning plate fixation can be used to treat comminuted distal radius fractures not amenable to volar plating. However, there is a relative paucity of outcomes data; so, the aim of this retrospective study was to investigate outcomes and complications after dorsal spanning plate fixation for distal radius fractures. Methods: Distal radius fractures treated with dorsal spanning plate fixation at a level-1 trauma center were retrospectively identified via Current Procedural Terminology coding and chart review from 2014 to 2019. Patient demographics, fracture pattern characteristics, fixation techniques, and clinical outcomes were all obtained via chart review using the electronic medical record. Results: In all, 43 dorsal plates were identified out of 369 operatively treated distal radius fractures (12%). Of these, 84% were AO type C, 28% were open fractures, and 86% resulted from falls. At the time of dorsal plating, 28% had an additional procedure. One patient had a major complication after surgery, requiring unplanned surgery for a radius nonunion. Average final follow-up occurred 9 weeks after dorsal plate removal, with mean range of motion at the wrist measuring: 36° flexion, 48° extension, 75° pronation, and 63° supination. Finger flexion was also measured, using either tip of finger to palm distance or total active motion, depending on the available data. These were measured at an average of 1.2 cm and 194°, respectively. Conclusions: Dorsal spanning plate fixation provides a safe and effective method for treating complex distal radius fractures. In our series, patients had good functional outcomes with few complications.
Prevalence, associated factors, and clinical consequences of metabolic syndrome in chronic obstructive pulmonary disease patients: a 5-year prospective observational study
Authors: Keeratichananont Warangkana , Kaenmuang Punchalee , Geater Sarayut Lucien , Manoret Premanan , Thanapattaraborisuth Banthita 
Published: April 2023

Background: Chronic obstructive pulmonary disease (COPD) is characterized by multiple systemic comorbidities, not only airflow limitation. Metabolic syndrome (MetS) is a common comorbidity. Patients with COPD have a higher risk of MetS than do healthy individuals. Objectives: We aimed to investigate the prevalence of and explore the factors associated with MetS in Thai COPD patients and to assess the clinical consequences of MetS after a 5-year follow-up period. Methods: A prospective observational study was conducted in patients with stable COPD at Songklanagarind Hospital between June 2015 and November 2019. MetS was defined according to the International Diabetes Federation 2005 criteria. The patients were followed-up for 5 years. The prevalence, associated factors, and consequences of MetS were analyzed. Results: A total of 115 patients with COPD were enrolled, of whom 95.3% were male. The overall prevalence of MetS was 37.4% (43 patients). Chronic bronchitis and high C-reactive protein (CRP) levels were independently and significantly associated with MetS in patients with COPD ( p = 0.036 and 0.044, respectively). After following patients for 5 years, the incidence of cardiovascular disease and stroke, exacerbation rate, and mortality rate were significantly higher in the COPD with MetS group [relative risk (RR) = 15.36, 95% confidence interval (CI) = (2.13–110.67), RR = 45.43, 95% CI = (4.61–447.07), RR = 1.94, 95% CI = (1.40–2.70), and RR = 48.01, 95% CI = (1.12–2049.43), respectively]. Conclusion: The prevalence of MetS is high in patients with COPD. Chronic bronchitis and high CRP levels are associated with MetS in COPD. The incidence of clinical consequences was significantly higher in patients with COPD and MetS after a 5-year follow-up. Screening for MetS is strongly recommended for all patients with COPD.
Developing better understanding of hygiene is key to developing hygiene behaviour change in home and everyday life settings
Authors: Bloomfield S , Ackerley L 
Published: April 2023

Aims: Polling indicates the public has fairly good knowledge of times when hygiene is needed in their homes and everyday life in public spaces, but limited understanding of hygiene risk; this results in omitting some key behaviours and incorrectly applying untargeted behaviours. This poll explores how the public responded to government advice, and information from other sources, to address a specific disease threat – that is, COVID-19 infection. Methods: An online poll was developed, and data were collected from 1730 respondents in England aged 18 and above. Results: Data suggest that the UK public has a high level of concern about the importance of hygiene to prevent spread of COVID-19. They had good recall of advice given during the pandemic and were able to identify routes of infection transmission. When asked to identify key times for handwashing, most people (86%–90%) identified ‘after coughing, sneezing etc., before eating food with fingers, after touching contact surfaces and when returning home’, but a similar number also identified using the toilet, food handling and pet handling, despite the fact that government advice does not identify these as risk actions for COVID-19. This suggests they were unable to use their knowledge of how the virus spreads to make informed decisions about when to practice hygiene. Despite government guidance, public practices are still influenced by a conviction that deep cleaning, including non-targeted disinfectant usage on environmental surfaces, gives added protection, leading them to practise additional cleaning and disinfection in situations where there is little benefit. Conclusions: New insights from public polling, together with the nine moments Targeted Hygiene approach, offer a more robust communications approach to enable the public to make cognitive links between when, where, how and why to practise good hygiene, and in doing so, promote more effective and sustainable behaviours.
Circulating tumor cells dynamics during chemotherapy predict survival and response in advanced non-small-cell lung cancer patients
Authors: Wang Zhen , Zhang Xu-Chao , Feng Wei-Neng , Zhang Li , Liu Xiao-Qing , Guo Wei-Bang , Deng Yan-Ming , Zou Qing-Feng , Yang Jin-Ji , Zhou Qing , Wang Bin-Chao , Chen Hua-Jun , Tu Hai-Yan , Yan Hong-Hong , Wu Yi-Long 
Published: April 2023

Background: Circulating tumor cells (CTCs) are prognostic biomarker in non-small-cell lung cancer (NSCLC). CTCs could also be used as predictor of efficacy of systemic treatments in advanced NSCLC. Objectives: We described the dynamic changes of CTCs during first-line platinum-based chemotherapy in advanced NSCLC and clarified the correlation between CTC counts and efficacy of chemotherapy. Design: Chemotherapy is administered and blood specimens are collected at four time points from baseline to disease progression for CTC detection. Methods: This multicenter prospective study enrolled patients with previously untreated stage III or IV NSCLC fit for standard platinum-based chemotherapy. Bloods were sampled as per standard operating procedures at baseline, cycle 1 and cycle 4 of chemotherapy, and at disease progression for CTC analysis using the CellSearch system. Results: Among 150 patients enrolled, median overall survival (OS) was 13.8, 8.4, and 7.9 months in patients with CTC−, KIT−CTC, and KIT+CTC at baseline ( p = 0.002). Patients with persistent negative CTC (46.0%) had longer progression-free survival [5.7 months, 95% confidence interval (CI): 5.0–6.5 versus 3.0 months, 0.6–5.4; hazard ratio (HR): 0.34, 95% CI: 0.18–0.67) and OS (13.1 months, 10.9–15.3 versus 5.6 months, 4.1–7.1; HR: 0.17, 0.08–0.36) compared with patients with persistent positive CTC (10.7%), which was not impacted by chemotherapy. Chemotherapy decreased CTC from 36.0% (54/150) to 13.7% (13/95). Conclusions: CTC persistent presence during treatment represents poor prognosis and resistance to chemotherapy in advanced NSCLC. Chemotherapy could effectively eliminate CTCs. Molecular characterization and the functionalization of CTC will be warranted for further intensive investigation. Trial registration: NCT01740804.
IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81
Authors: Luo Ziwei , Han Qianting , Lu Jianghua , Ouyang Xiyan , Fan Yueying , Liu Yangping , Zhou Xianxi , Kong Jiechen , Liu Helu , Liu Aijun , Chen Dongfeng 
Published: April 2023

Objective Functional polymorphisms of interleukin 16 (IL16) have been reported to be closely related to the risk of osteoarthritis (OA). However, how IL16 affects OA remains unclear. In this study, the role of IL16 in OA and the possible mechanisms were examined. Methods We established a meniscal/ligament injury (MLI) post-traumatic OA model in Sprague Dawley rats and an IL1β-induced ADTC5 cells OA model. We detected the expression of IL16, novel-miR-81, MMP3, and MMP13 by quantitative real-time polymerase chain reaction. Western blot was performed to detect the expression of IL16, MMP3, and MMP13. The association between IL16 and novel-miR-81 was confirmed by luciferase reporter assay. Hematoxylin and eosin staining, Safranin O and Fast Green staining, and immunohistochemical staining were performed to clarify the effect of intra-articular injection of novel-miR-81 agomir in rats OA model. Results IL16 was upregulated in OA model. Knockdown of IL16 and overexpression of novel-miR-81 downregulated the expression of MMP3 and MMP13. Importantly, IL16 was a key target of novel-miR-81. Intra-articular injection of novel-miR-81 agomir could attenuate OA progression in rats OA model. Conclusion Novel-miR-81 targeted IL16 to relieve OA, suggesting that novel-miR-81and IL16 may be new therapeutic targets for OA.
Complications prevention of shoulder balance support device for lateral decubitus position: A randomized controlled trial
Authors: Piyasoontrawong Nicha , Sirisreetreerux Pokket , Kochakarn Wachira 
Published: April 2023

Objectives: The authors invented the shoulder balance support device aiming to prevent skin complications and neck pain in surgical patients operated in lateral decubitus position. This study aimed to compare skin complications and neck pain between patients with shoulder balance support device and traditional positioning instruments and to assess surgeons’ and anesthesiologists’ satisfaction in using the device. Methods: A randomized controlled trial, which followed Consolidated Standards of Reporting Trials(CONSORT) statement, was conducted in patients who underwent laparoscopic upper urinary tract surgery in the lateral decubitus position from June 2019 to March 2020. The shoulder balance support device was used in 22 patients and 22 other patients were in the control group. The area of skin erythema, bruising, or abrasion resulting from the pressure effect of the lateral decubitus position was measured and the pain score for the neck and shoulder area after the operation was assessed. Furthermore, the satisfaction of the medical personnel taking care of the patients and using the shoulder balance support device was investigated. Results: A total of 44 patients were included. No patient in the intervention group reported neck pain. Skin erythema was found in six patients in each group and the median area of skin erythema was significantly smaller in the intervention group. Most of the medical personnel reported satisfaction with use of the device. Conclusion: This device is an innovative tool with the aim of ultimate care for surgical patients. Clinical Trial Registration Number: Thai Clinical trials registry ID TCTR 20190606002
Prostate-specific antigen doubling time following radium-223 treatment as a predictor of the clinical course in patients with metastatic castration-resistant prostate cancer
Authors: Kawaguchi Gen , Akazawa Kohei , Ikeda Taro , Ikeda Yohei , Hara Noboru , Nishiyama Tsutomu 
Published: April 2023

Objectives: To identify useful biomarkers by reviewing laboratory data for a predictor of the clinical course following treatment with radium-223 dichloride (Ra-223) in patients with metastatic castration-resistant prostate cancer. Methods: Eighteen metastatic castration-resistant prostate cancer patients who were administered Ra-223 at our hospital were retrospectively enrolled in this study. Prostate-specific antigen doubling times before and after the administration of Ra-223 were evaluated as prognostic factors for metastatic castration-resistant prostate cancer patients treated with Ra-223 using the Kaplan–Meier method and Log-rank test. Results: Four patients failed to complete the planned six-time Ra-223 treatments with the exacerbation of their condition. In the 14 patients who completed the planned Ra-223 treatment, before the Ra-223 treatment, no significant differences were observed in overall survival between patients with prostate-specific antigen doubling time of 6 months or less and those with prostate-specific antigen doubling time of more than 6 months or stable ( p = 0.642). Following the completion of the Ra-223 treatment, overall survival was significantly shorter in patients with prostate-specific antigen doubling time of 6 months or less than in those with prostate-specific antigen doubling time of more than 6 months or stable ( p = 0.007). Conclusion: Prostate-specific antigen doubling time after the Ra-223 treatment is a useful predictor of the clinical course following treatment in metastatic castration-resistant prostate cancer patients.
How does community engagement evolve in different compassionate community contexts? A longitudinal comparative ethnographic research protocol
Authors: Lessard Émilie , Marcoux Isabelle , Daneault Serge , Panaite Andreea-Catalina , Jean Lise , Talbot Mélodie , Weil Dale , Rouly Ghislaine , Sallnow Libby , Kellehear Allan , Boivin Antoine 
Published: April 2023

Background: Compassionate communities build on health promoting palliative care that aims to address gaps in access, quality, and continuity of care in the context of dying, death, loss, and grief. While community engagement is a core principle of public health palliative care, it has received little attention in empirical studies of compassionate communities. Objectives: The objectives of this research are to describe the process of community engagement initiated by two compassionate communities projects, to understand the influence of contextual factors on community engagement over time, and assess the contribution of community engagement on proximal outcomes and the potential for sustaining compassionate communities. Research Approach and Design: We use a community-based participatory action-research approach to study two compassionate communities initiatives in Montreal (Canada). We develop a longitudinal comparative ethnographic design to study how community engagement evolves in different compassionate communities contexts. Methods and Analysis: Data collection includes focus groups, review of key documents and project logbooks, participant observation, semi-structured interviews with key informants, and questionnaires with a focus on community engagement. Grounded in the ecology of engagement theory and the Canadian compassionate communities evaluation framework, data analysis is structured around longitudinal and comparative axes to assess the evolution of community engagement over time and to explore the contextual factors influencing the process of community engagement and its impacts according to local context. Ethic: This research is approved by the research ethics board of the Centre hospitalier de l’Université de Montréal (approval certificate #18.353). Discussion: Understanding the process of community engagement in two compassionate communities will contribute to a deeper understanding of the relationships between local context, community engagement processes, and their effect on compassionate communities outcomes.
Patient-Reported Usefulness and Challenges in Using Hypoglycemia-Informing Features of Continuous Glucose Monitors to Manage Hypoglycemia
Authors: Lin Yu Kuei , Agni Annika , Chuisano Samantha , Fetters Michael D. , Funnell Martha , Pop-Busui Rodica , DeJonckheere Melissa J. 
Published: April 2023

Purpose: The purpose of this study series, which involves a questionnaire survey and qualitative interviews, was to (a) evaluate patient-reported usefulness of continuous glucose monitor (CGM) hypoglycemia-informing features and (b) identify challenges in using these features (ie, CGM glucose numbers, trend arrows, trend graphs, and hypoglycemia alarms) during hypoglycemia in adults with type 1 diabetes (T1DM). Methods: A cross-sectional questionnaire survey study was conducted with adults who have T1DM and were using CGMs to assess the perceived usefulness of hypoglycemia-informing features. A semistructured interview study with T1DM CGM-using adults and inductive thematic analysis were subsequently performed to identify challenges in using CGM hypoglycemia-informing features to manage hypoglycemia. Results: In the survey study (N = 252), the CGM glucose numbers, trend arrows, trend graphs, and hypoglycemia alarms were found to be very useful by 79%, 70%, 43%, and 64% of participants, respectively. Several challenges in using these features to manage hypoglycemia were identified in the qualitative study (N = 23): (1) hypoglycemia information not fully reliable,; (2) unpredictability of future blood glucose levels, (3) lack of awareness about how information can be used, and (4) disruptions associated with information. Conclusions: Although the majority of T1DM adults found their CGMs’ hypoglycemia-informing features helpful, challenges in optimally using these features persisted. Targeted knowledge and behavioral interventions could improve CGM use to reduce hypoglycemia.
Does Camera Type Affect Patient Comfort? An Analysis of Patient Opinions of Office Photography
Authors: Tarr Joseph T. , Hazkour Nissim , Goote Paige , Kwon Bogum , Rivera Robin , Bastidas Nicholas , Moon Victor A. 
Published: April 2023

Purpose: Photography is an essential part to plastic surgery in terms of procedural planning and documentation. With the increasing quality of commercially available digital cameras, an investigation of the effect of camera type on patient perception of the office visit is necessary. Therefore, we aim to investigate the impact of using a traditional DSLR style camera versus a smartphone in office-based patient photography. Method: A Likert scale survey was completed by patients following office visits to assess comfort with office photography. Key points included: sex, age, number of previous visits, comfort with photographic experience, and camera type used. Results: 100 patients (78 F, 21 M) were included; 47 had photographs taken with a DSLR camera and 52 had photos taken with a smartphone. The mean decade of cohort age was 40 to 49 years old. No statistical difference in patient comfort between DSLR camera and smartphone use was observed (4.71 ± 0.72 vs 4.64 ± 0.57, P: .58). When data was stratified by sex or number of previous visits, there was still no difference in comfort across camera types. There was no significant main effect of age on comfort level ( P = .109); However, a post-hoc Tukey’s analysis showed significant comfort differences between the <18 and 18-29 subgroups and the <18 and 60 to 69 subgroups ( P = .040 and P = .041 respectively). Conclusion: Patients were overall equally comfortable with their photographic experience when providers used either camera. Smartphone cameras, therefore, should be regarded as a suitable alternative for office use without fear of invoking negative perceptions in patients.
Comparison of postoperative nausea and vomiting between Remimazolam and Propofol in Patients undergoing oral and maxillofacial surgery: a prospective Randomized Controlled Trial
Authors: Kim Eun-Jung , Kim Cheul-Hong , Yoon Ji-Young , Byeon Gyeong-Jo , Kim Hee Young , Choi Eun-Ji 
Published: April 2023

Abstract
Background
Remimazolam is a recently approved, ultra-short-acting benzodiazepine. However, few studies have investigated remimazolam in relation to postoperative nausea and vomiting (PONV). This study aimed to compare the effects of remimazolam and propofol on PONV in patients undergoing oral and maxillofacial surgery.

Methods
Patients (n = 206) aged 19–65 years who were scheduled for oral and maxillofacial surgery were randomized into two groups, the remimazolam (R) and propofol group (P). In the R group (n = 94), remimazolam was used to induce anesthesia at 12 mg/kg/h and to maintain anesthesia at 1–2 mg/kg/h. In the P group (n = 95), anesthesia was induced and maintained with propofol (target effect-site concentration: 3–5 µg/ml). In both groups, remifentanil was administered at a target effect-site concentration of 2.5-4 ng/ml. The primary outcome was the overall incidence of PONV during the first 24 h after surgery. Secondary outcomes included the severity of nausea, use of rescue antiemetics, severity of postoperative pain, use of rescue analgesia, and quality of recovery.

Results
The incidence of PONV during the first 24 h after surgery was 11.7% and 10.5% in the R group and P group, respectively, and there was no significant difference in the severity of nausea (P > 0.05). Ten patients in the R group and ten patients in the P group required rescue antiemetics during the first 24 h after surgery (P = 0.98). No inter-group differences were observed in terms of postoperative pain score, use of rescue analgesia, and quality of recovery (P > 0.05).

Conclusions
In this study, remimazolam did not increase the incidence and severity of PONV compared with propofol.

Trial registration
KCT0006965, Clinical Research Information Service (CRIS), Republic of Korea. Registration date: 26/01/2022.