bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance assessment of hemispherical solar distillers integrated with the red bricks filled with cement as natural thermal storage materials
Authors: Attia Mohammed El Hadi , Kabeel Abd Elnaby , Beggas Azzeddine , Abdelgaied Mohamed 
Published: March 2023

AbstractThis manuscript aims to augment the production rate of drink water from the hemispherical solar distillers using red bricks filled with cement as natural low‐cost reasonable storage materials. To obtain the optimal height and optimal gap distance of the red brick tiles filled with cement that achieves the highest productivity of hemispherical distillers. Three different heights of the red brick (1, 2, and 3 cm) with two different gap distances of (4 and 6 cm) were experimentally studied. Therefore, three hemispherical distillers were constructed and operated under the same climate conditions. The first is the traditional hemispherical solar distiller (THSD) which represents the reference distiller. The second is a hemispherical distiller with red brick tiles filled with cement set at a gap distance of 6 cm. The third is a hemispherical distiller with red brick tiles filled with cement set at a gap distance of 4 cm. The results presented that, the utilization of red brick tiles filled with cement with a height of 2 cm and a gap distance of 4 cm represents a good choice that achieves the highest performance of hemispherical distillers. The results showed that the utilization of red bricks filled with cement will be improved the accumulative yield from 4.3 L/m2/day (THSD) to 6.55 L/m2/day with an improvement of 52.3%. Also, using the red bricks filled with cement improved the thermal and exergy efficiencies by 51.24% and 435.5%, respectively compared to THSD.
Optimization and planning of renewable energy sources based microgrid for a residential complex
Authors: Hasan Sayeed , Zeyad Mohammad , Ahmed S.M. Masum , Anubhove Md. Sadik Tasrif 
Published: March 2023

AbstractWorld population growth and increased energy demand are taking a heavy toll on the environment. Aside from developed countries, the adverse effects are far more apparent in third‐world countries, which are also affected by climate change, pollution, and fuel scarcity. One of the primary solutions to this challenge is the implementation of cleaner and more sustainable energy resources. Building scale renewable integration is one of the solutions included in hybrid energy systems. The article aims to design a grid‐tied hybrid energy system for a residential complex in Dhaka, Bangladesh. The design includes several combinations of the photovoltaic system, diesel generator, and battery energy storage system (BESS). The key objectives of the analysis are to minimize system costs, reduce grid dependency, and reduce emissions. Various models were simulated in Hybrid optimization of multiple energy resources (HOMER Pro) to obtain a suitable system with maximum renewable usage. Several systems were compared based on different parameters such as net present cost (NPC), operating cost, cost of energy (COE), and carbon emissions. A grid‐tied system with PV and lithium battery storage was found to be the most suitable system for powering the residential load. From the analysis, the preferred system can reduce COE by 53%, NPC by 26%, and operating costs by 54%. Also, the total emission is reduced by 31%. Aside from being cost‐effective, the proposed system is also convenient and sustainable, with fewer salvageable parts owing to its use of lithium‐based BESS.
Recent development of pH‐responsive theranostic nanoplatforms for magnetic resonance imaging‐guided cancer therapy
Authors: Li Xu , Yue Renye , Guan Guoqiang , Zhang Cheng , Zhou Ying , Song Guosheng 
Published: March 2023

AbstractThe acidic characteristic of the tumor site is one of the most well‐known features and provides a series of opportunities for cancer‐specific theranostic strategies. In this regard, pH‐responsive theranostic nanoplatforms that integrate diagnostic and therapeutic capabilities are highly developed. The fluidity of the tumor microenvironment (TME), with its temporal and spatial heterogeneities, makes noninvasive molecular magnetic resonance imaging (MRI) technology very desirable for imaging TME constituents and developing MRI‐guided theranostic nanoplatforms for tumor‐specific treatments. Therefore, various MRI‐based theranostic strategies which employ assorted therapeutic modes have been drawn up for more efficient cancer therapy through the raised local concentration of therapeutic agents in pathological tissues. In this review, we summarize the pH‐responsive mechanisms of organic components (including polymers, biological molecules, and organosilicas) as well as inorganic components (including metal coordination compounds, metal oxides, and metal salts) of theranostic nanoplatforms. Furthermore, we review the designs and applications of pH‐responsive theranostic nanoplatforms for the diagnosis and treatment of cancer. In addition, the challenges and prospects in developing theranostic nanoplatforms with pH‐responsiveness for cancer diagnosis and therapy are discussed.
Nanodrugs with intrinsic radioprotective exertion: Turning the double‐edged sword into a single‐edged knife
Authors: Guo Jiaming , Zhao Zhemeng , Shang Zeng‐Fu , Tang Zhongmin , Zhu Huanhuan , Zhang Kun 
Published: March 2023

AbstractIonizing radiation (IR) poses a growing threat to human health, and thus ideal radioprotectors with high efficacy and low toxicity still receive widespread attention in radiation medicine. Despite significant progress made in conventional radioprotectants, high toxicity, and low bioavailability still discourage their application. Fortunately, the rapidly evolving nanomaterial technology furnishes reliable tools to address these bottlenecks, opening up the cutting‐edge nano‐radioprotective medicine, among which the intrinsic nano‐radioprotectants characterized by high efficacy, low toxicity, and prolonged blood retention duration, represent the most extensively studied class in this area. Herein, we made the systematic review on this topic, and discussed more specific types of radioprotective nanomaterials and more general clusters of the extensive nano‐radioprotectants. In this review, we mainly focused on the development, design innovations, applications, challenges, and prospects of the intrinsic antiradiation nanomedicines, and presented a comprehensive overview, in‐depth analysis as well as an updated understanding of the latest advances in this topic. We hope that this review will promote the interdisciplinarity across radiation medicine and nanotechnology and stimulate further valuable studies in this promising field.
The association between dietary micronutrient patterns and odds of diabetic nephropathy: A case–control study
Authors: Bahrampour Niki , Mirzababaei Atieh , Abaj Faezeh , Hosseininasab Dorsa , Clark Cain C. T. , Mirzaei Khadijeh 
Published: March 2023

AbstractUncontrolled diabetes can lead to diabetic nephropathy (DN). The aim of the study was to investigate the relationship between different dietary micronutrient patterns and risk of DN in women. This was a case–control study. One hundred and five patients had DN (defined as urinary mg of albumin per gram of creatinine ≥30 mg/g) were chosen as the case and 105 women without DN were chosen as control. Dietary intakes were assessed by a semi‐quantitative food frequency questionnaire. Principal component analysis with varimax rotation was used to derive the micronutrient patterns. Patterns were divided into two groups of lower and higher than median. Logistic regression was used to discern and find the odds ratio (ORs) of DN, and its 95% confidence interval (CI) based on the micronutrient patterns in crude and adjusted model. Three patterns which were included, (1) mineral patterns such as chromium, manganese, biotin, vitamin B6, phosphorus, magnesium, selenium, copper, zinc, potassium, and iron, (2) water‐soluble vitamin patterns such as vitamin B5, B2, folate, B1, B3, B12, sodium and C, and (3) fat‐soluble vitamin patterns such as calcium, vitamin K, beta carotene, alpha tocopherol, alpha carotene, vitamin E, and vitamin A, were extracted. An inverse relationship was found between risk of DN and following mineral patterns and fat‐soluble vitamin patterns in adjusted model (ORs = 0.51 [95% CI 0.28–0.95], p = .03) and (ORs = 0.53 [95% CI 0.29–0.98], p = .04), respectively. No relationship was seen between water‐soluble vitamin patterns and risk of DN in crude and adjusted model but the significance was decreased in adjusted model. The risk of DN was 47% decreased after high adherence of fat‐soluble vitamin patterns. In addition, we saw a 49% decrease of risk of DN in high adherence group of mineral patterns. The findings confirm that renal‐protective dietary patterns can reduce risk of DN.
Physicochemical property changes of Dendrobium officinale leaf polysaccharide LDOP‐A and it promotes GLP‐1 secretion in NCI‐H716 cells by simulated saliva‐gastrointestinal digestion
Authors: Xiong Jingfang , Fang Jingyu , Chen Dongya , Xu Hong 
Published: March 2023

AbstractA polysaccharide LDOP‐A with a molecular weight of 9.9 kDa was isolated and purified from Dendrobium officinale leaves by membrane separation, cellulose column, and dextran gel column. The Smith degradable products, methylation products, and nuclear magnetic resonance analysis showed that LDOP‐A may be composed of →4)‐Glc‐(1→, →3,6)‐Man‐(1→, and →6)‐Glc‐(1→sugar residues. In vitro, simulated digestion assays showed that LDOP‐A could be partially digested in the stomach and small intestine, and produced a large amount of acetic acid and butyric acid during colonic fermentation. Further cell experiment results illustrated that LDOP‐A‐I (LDOP‐A digested by gastrointestinal tract) could induce glucagon‐like peptide‐1 (GLP‐1) secretion in NCI‐H716 cells without showing any cytotoxicity.
Effect of solution acidity on cytochrome c conformations of alternating current electrospray ionization mass spectrometry
Authors: Chen Hsiao‐Ping , Li Cheng‐Han , Chang Yut‐Zu , Hsieh Wen‐Shan , Wang Shau‐Chun 
Published: March 2023

AbstractThis paper reports notable observations regarding the ion charge states of thermally stable cytochrome c, generated using an alternating current (AC) electrospray ionization (ESI) device. An AC ESI sprayer entrains low‐mobility ions to accumulate at the meniscus cone tip prior to the ejection of detached aerosols to produce analyte ions. Therefore, as the solvent acidity varies, protein ions entrained in the AC cone tip are found to change conformation less significantly compared with those in the direct current (DC) cone. We acquired the AC ESI mass spectra of cytochrome c at pH range from 2 to 4. Unlike the DC ESI mass spectra showing clear conformation changes due to denaturing, the AC spectra indicated that only partial denaturing occurs even at extremely acidic pH 2. More native cytochrome c in lower charge states therefore remained. Moreover, with a solvent mixture of aqueous buffer and acetonitrile (70:30), partially denatured cytochrome c was still preserved at pH 2 by using AC ESI. Completely denatured proteins are observed at pH 2 by using DC ESI.
Normative values of hand grip strength in a large unselected Chinese population: Evidence from the China National Health Survey
Authors: He Huijing , Pan Li , Wang Dingming , Liu Feng , Du Jianwei , Pa Lize , Wang Xianghua , Cui Ze , Ren Xiaolan , Wang Hailing , Peng Xia , Zhao Jingbo , Shan Guangliang 
Published: March 2023

AbstractBackgroundHand grip strength (HGS) is a powerful indicator of sarcopenia and other adverse health outcomes. Normative values for HGS for general Chinese people with a broad age spectrum are lacking. This study aims to establish normative values of HGS and explore the correlations between HGS and body composition among unselected people aged 8–80 in China.MethodsFrom 2012 to 2017, 39 655 participants aged 8–80 years in the China National Health Survey were included. Absolute HGS was measured using a Jamar dynamometer. The relative HGS was normalized by body mass index. Body composition indexes included body mass index, body fat percentage, muscle mass, fat mass index (FMI) and muscle mass index (MMI). Sex‐specific smoothed centile tables for the P1, P5, P25, P50, P75, P95 and P99 centiles of HGS and body composition were generated using lambda‐mu‐sigma method. The correlations between muscle strength and body composition were estimated by partial Spearman correlation analysis.ResultsThe median values (25th and 75th percentile) of HGS in boys and girls (8–19 years old) were 22 (14, 34) kg and 18 (12, 22) kg, respectively; in men and women aged 20–80 were 39 (33, 44) kg and 24 (20, 27) kg, respectively. Values of upper and lower HGS across ages had three periods: an increase to a peak in the 20 s in men (with the 5th and 95th values of 30 and 55 kg, respectively) and 30 s in women (with the 5th and 95th values of 18 and 34 kg, respectively), preservation through midlife (20s–40 s), and then a decline after their 50 s. The lowest HGS values in both sexes were in the 70‐ to 80‐year‐old group, with the 5th and 95th percentile values of 16 and 40 kg in men, and 10 and 25 kg in women. There were substantial sex differences in body composition in the life course (all P values <0.001). In ageing, the decrease of muscle strength was faster than that of muscle mass in both sexes. The correlations between muscle mass and HGS were most robust than other correlations, especially in women (0.68 vs. 0.50), children and adolescents.ConclusionsOur study established the age‐ and sex‐specific percentile reference values for hand grip strength in an unselected Chinese population across a broad age‐spectrum. The rich data can facilitate the practical appraisal of muscle strength and promote early prediction of sarcopenia and other impairments associated with neuromuscular disorders.
Influence of carbon nanotube functionalization on the physical properties of PCL diol/chitosan blends
Authors: Antolin‐Ceron V.H. , Gonzalez‐Jauregui D. , Astudillo‐Sanchez P.D. , Cabrera‐Chavarria J. , Andrade‐Melecio H.A. , Barrera‐Rivera K.A. , Martinez‐Richa A. 
Published: March 2023

AbstractBACKGROUNDChitosan‐poly(ε)caprolactone diol (PCL) blends were studied for food packaging film applications. The mechanical and thermal properties of blend films can be regulated with different amounts of PCL and the addition of a nanofiller could reinforce specific domains in the blend to generate nanocomposites with desirable properties for food packaging. This is evidence of the selective insertion of functionalized carbon nanotubes in either PCL or chitosan domains, depending on the nature of chemical groups and the structure over the surface nanofiller.RESULTSMultiwalled carbon nanotubes (MWNTs) were functionalized with four different dendritic molecules and were tested as nanofillers to reinforce biodegradable films made from 70 to 30, 80 to 20, and 90 to 10 Chitosan‐PCL blends in an effort to explore their effects on the barrier and mechanical properties of the yielded nanocomposites. PCL was obtained by biocatalysis from ɛ‐caprolactone and diethylene glycol and then blended with commercial chitosan. Blends were prepared from a solution of chitosan in acetic acid (2% wt/wt), adding PCL diol in chloroform dropwise under stirring. The MWNTs were modified with several functional groups (tannic acid via no‐covalent functionalization, poly(citric acid), poly(urea‐urethane), and poly(amino‐amido) dendrimer). Nanocomposites were obtained by adding in situ 0.5 wt/wt functionalized MWNTs during the preparation of blends. The structural interactions, morphological, and mechanical features of MWNTs/Blend nanocomposites were studied by Fourier‐transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscope (SEM), field emission scanning electron microscopy (FE‐SEM), and strain–stress testing.CONCLUSIONSPreferential interactions between nanofiller and matrix strongly depend on the nature of the nanofiller and the amount of hydrogen bonding species. It was possible to reinforce a particular domain in the blend to generate nanocomposites with desirable/tunable properties by using complementary chemical groups onto MWNTs surface. © 2023 Society of Chemical Industry (SCI).
Changes in UK parental mental health symptoms over 10 months of the COVID‐19 pandemic
Authors: Skripkauskaite Simona , Creswell Cathy , Shum Adrienne , Pearcey Samantha , Lawrence Pete , Dodd Helen , Waite Polly 
Published: March 2023

AbstractBackgroundThe threats to health, associated restrictions and economic consequences of the COVID‐19 pandemic have been linked to increases in mental health difficulties for many. Parents, in particular, have experienced many challenges such as having to combine work with home‐schooling their children and other caring responsibilities. Yet, it remains unclear how parental mental health has changed throughout the pandemic or what factors may have mitigated or compounded the impact of the pandemic on parents' mental health.MethodsWe examined monthly survey data from two linked UK‐based longitudinal studies: COVID‐19: Supporting Parents, Adolescents and Children during Epidemics' (Co‐SPACE) and COVID‐19: Supporting Parents and Young Children during Epidemics' (Co‐SPYCE). Data from 5576 parents/carers of 2–17‐year‐old children collected between April 2020 and January 2021 was analysed using mixed‐effect modelling and latent class growth (mixture) modelling.ResultsParental stress and depression, but not anxiety, were higher during the periods of restrictions. This pattern was most pronounced for parents with primary‐school‐aged children, those that worked at home or had other adults in the household. Being younger, reporting secondary or below education, working out of home, having secondary‐school‐aged children or children with special education needs (SEN)/neurodevelopmental disorders (ND) further moderated whether, how and when parental mental health symptoms changed. Although around three quarters of parents reported consistently low mental health symptoms, a substantial minority reported consistently high or increasing symptoms of anxiety, stress and depression. The latter were more likely to be parents who were younger than average, were a single adult in the household, had a pre‐existing mental health diagnosis or had a child with special educational needs or a ND.ConclusionsThese findings emphasise how different personal circumstances and pre‐existing inequalities shaped how parents were affected by this unprecedented global pandemic and highlight the need for support and consideration to meet the needs of families in the future.
Standardising the preanalytical reporting of biospecimens to improve reproducibility in extracellular vesicle research – A GEIVEX study
Authors: López‐Guerrero José A. , Valés‐Gómez Mar , Borrás Francesc E. , Falcón‐Pérez Juan Manuel , Vicent María J. , Yáñez‐Mó María 
Published: March 2023

AbstractThe standardization of clinical studies using extracellular vesicles (EVs) has mainly focused on the procedures employed for their isolation and characterization; however, preanalytical aspects of sample collection, handling and storage also significantly impact the reproducibility of results. We conducted an online survey based on SPREC (Standard PREanalytical Code) among members of GEIVEX (Grupo Español de Investigación en Vesiculas Extracelulares) to explore how different laboratories handled fluid biospecimens destined for EV analyses. We received 70 surveys from forty‐three different laboratories: 44% focused on plasma, 9% on serum and 16% on urine. The survey indicated that variability in preanalytical approaches reaches 94%. Moreover, in some cases, researchers had no access to all relevant preanalytical details of samples, with some sample aspects with potential impact on EV isolation/characterisation not coded within the current version of SPREC. Our study highlights the importance of working with common standard operating procedures (SOP) to control preanalytical conditions. The application of SPREC represents a suitable approach to codify and register preanalytical conditions. Integrating SPREC into the SOPs of laboratories/biobanks will provide a valuable source of information and constitute an advance for EV research by improving reproducibility and credibility.
Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR‐3473b/phosphatase and tensin homolog axis
Authors: Zhang Yueqi , Qi Guobin , Yan Yuheng , Wang Chenzhong , Wang Zhe , Jiang Chang , Jiang Zengxin , Ma Tianle , Zhang Chi , Yan Zuoqin 
Published: March 2023

AbstractBackgroundOsteoarthritis (OA) is a prevalent degenerative articular disease for which there is no effective treatment. Progress has been made in mesenchymal stem cell (MSC)‐based therapy in OA, and the efficacy has been demonstrated to be a result of paracrine exosomes from MSCs. Decellularized extracellular matrix (dECM) provides an optimum microenvironment for the expansion of MSCs. In the present study, we aimed to investigate whether exosomes isolated from bone marrow mesenchymal stem cells (BMSCs) with dECM pretreatment (dECM‐BMSC‐Exos) enhance the amelioration of OA.MethodsExosomes from BMSCs with or without dECM pretreatment were isolated. We measured and compared the effect of the BMSC‐Exo and dECM‐BMSC‐Exo on interleukin (IL)‐1β‐induced chondrocytes by analyzing proliferation, anabolism and catabolism, migration and apoptosis in vitro. The in vivo experiment was performed by articular injection of exosomes into DMM mice, followed by histological evaluation of cartilage. MicroRNA sequencing of exosomes was performed on BMSC‐Exo and dECM‐BMSC‐Exo to investigate the underlying mechanism. The function of miR‐3473b was validated by rescue studies in vitro and in vivo using antagomir‐3473b.ResultsIL‐1β‐treated chondrocytes treated with dECM‐BMSC‐Exos showed enhanced proliferation, anabolism, migration and anti‐apoptosis properties compared to BMSC‐Exos. DMM mice injected with dECM‐BMSC‐Exo showed better cartilage regeneration than those injected with BMSC‐Exo. Interestingly, miR‐3473b was significantly elevated in dECM‐BMSC‐Exos and was found to mediate the protective effect in chondrocytes by targeting phosphatase and tensin homolog (PTEN), which activated the PTEN/AKT signaling pathway.ConclusionsdECM‐BMSC‐Exo can enhance the alleviation of osteoarthritis via promoting migration, improving anabolism and inhibiting apoptosis of chondrocytes by upregulating miR‐3473b, which targets PTEN.