bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Male Breast Cancer study in the Czech Republic: Treatment and Prognosis Experience Over 11 Years in 256 Cases
Authors: Bielcikova Zuzana , Holanek Milos , Selingerova Iveta , Sorejs Ondrej , Kolarova Iveta , Soumarova Renata , Proks Jan , Reifova Lucie , Cmejlova Vlastimila , Linkova Lenka , Zabojnikova Michaela , Chodacka Martina , Janovska Lucie , Lisnerova Lenka , Kasparova Karolina , Pohankova Denisa 
Published: April 2023

Abstract
Purpose
To analyze clinicopathologic characteristics, treatment procedures, and prognosis of men with breast cancer (MBC) in the Czech Republic and compare them with international data.
Methods
Men diagnosed with breast cancer in 2007–2017 were retrospectively identified from the databases of Complex Oncological Centers in the Czech Republic, and subsequently clinical, histopathological, and molecular-genetic characteristics, treatment procedures, and long-term treatment outcomes were evaluated. Prognostic factors of survival outcomes (overall survival, relapse-free survival, and breast cancer-specific mortality) were analyzed using Cox and the competing risks model.
Results
In this study, data from 256 patients with MBC at a median age of 66 years were analyzed. Of 201 patients with primary non-metastatic (M0) radically treated MBC, 6% were younger than 40 years, 29% had stage I, 55% were node-negative (cN0), and 54% were indicated to genetic testing. Estrogen receptor (ER) expression over 10% had 97% of tumors, 61% had high mitotic activity (Ki67), 40% high grade (G3), and 68% Luminal B-like (HER2- negative) subtype. Regarding the therapy, 97% of men underwent mastectomy (ME), 34% sentinel lymph node biopsy (SLNB), 48% adjuvant radiotherapy (RT), 13% neoadjuvant therapy, 44% adjuvant chemotherapy (CT), 90% adjuvant endocrine therapy (ET), of which 74% adjuvant tamoxifen (TMX). Patients treated with aromatase inhibitor (AI) alone had significantly shortened RFS (p < 0.001). There were also associations between OS/RFS/BCSM and disease stage, T, N, progesterone receptor (PR) expression, G and Ki67. Median OS reached 122 months in curatively treated M0 patients, 42 months in the de novo metastatic (M1) group (N = 30), and 39 months in the group of M0/X patients treated with palliative intention (N = 25).
Conclusion
Although the number of MBC cases with unfavorable features (young age, M1 cases, predominant Luminal B-like tumors) was higher in the Czech dataset compared to international studies, the prognosis of men remains consistent with the real-world published data.
Computational fluid dynamics simulation of tree effects on pedestrian wind comfort around coastline building resort
Authors: Swarno Husna Aini , Ahmad Nurul Huda , Mohammad Ahmad Faiz , Othman Nurnida Elmira 
Published: April 2023

AbstractThis paper discusses the quantitative effect of vegetative windbreak on wind velocity at a resort building in Malaysia. The implementation of vegetative windbreaks was proposed to reduce wind velocity and improve pedestrian wind comfort, especially in the coastline areas in Cenang, Langkawi. By comprehensive analysis of the data from field measurement and computer simulation from computational fluid dynamics (CFD), this paper studies tree effects on pedestrian wind comfort with different row numbers and arrangements. The simulation is validated by wind tunnel experiment, and the RNGk-εturbulence closure scheme used in the simulation provides good predictions of the airflow field for both single and double rows trees. The study shows the morphologies of the CE tree have a great influence on the flow field with a conical shape with large bottoms and small tops providing a better wind reduction efficiency due to the larger upward cross-flow component which exhibited better windbreak efficiency. A single row tree is the most efficient in reducing wind velocity and providing good comfort for traversing, strolling, and moderate for sitting compared with double rows which are poor comfort in sitting.
CX43 and oxidative stress are the targets of BCB staining to predict the developmental potential of buffalo oocytes
Authors: Li MengQi , Yang ChunYan , Duan AnQin , Xiao Peng , Lu XingRong , Ma XiaoYa , Xu YuanYuan , Zheng Wei , Feng Chao , Mo Xia , Huang ChenQian , Huang LiQing , Shang JiangHua , Zheng HaiYing 
Published: April 2023

Abstract
Background
Brilliant cresyl blue (BCB) staining can stain oocytes and differentiated oocytes will lead to different developmental outcomes. This technique has been studied in multiple species, but it is still unclear whether buffalo oocytes can be used for developmental potential prediction through BCB staining methods. This study used the BCB staining method to group buffalo oocytes (BCB + and BCB-) and perform in vitro maturation, in vitro fertilization, and embryo culture. By statistical analysis, the effect of BCB staining on predicting the developmental potential of buffalo oocytes will be explored. At the same time, molecular biology techniques will be used to detect gap junction protein and oxidative stress-related indicators to explore the molecular mechanism of BCB staining predicting oocyte cell developmental potential.
Methods
The oocytes were divided into BCB + and BCB- groups using BCB staining technique. And then mainly uses in vitro maturation, in vitro fertilization and embryo culture techniques of buffalo oocytes to analyze their developmental potential, and uses immunofluorescence staining to detect the expression level of CX43 protein, DCFH-DA probe staining to detect ROS levels, and qPCR to detect the expression levels of the antioxidant related genes SOD2 and GPX1.
Results
Our results showed that the in vitro maturation rate, embryo cleavage rate, and blastocyst rate of buffalo oocytes in the BCB + group were significantly higher than those in the BCB- group and the control group (P < 0.05). The expression level of CX43 protein in the BCB + group was higher than that in the BCB- group both before and after maturation (P < 0.05). The intensity of ROS in the BCB + group was significantly lower than that in the BCB- group (P < 0.05), and the expression levels of the antioxidant-related genes SOD2 and GPX1 in the BCB + group were significantly higher than those in the BCB- group (P < 0.05).
Conclusions
BCB staining can effectively predict the developmental potential of buffalo oocytes. The results of BCB staining are positively correlated with the expression of gap junction protein and antioxidant-related genes and negatively correlated with the ROS level, suggesting that the mechanism of BCB staining in predicting the developmental potential of buffalo oocytes may be closely related to antioxidant activity.
Long-term Follow-up over 16 Years for Pituitary Hyperplasia due to Primary Hypothyroidism with Positive Thyroid Stimulation Blocking Antibody: A Case Report
Authors: Kawasumi Muneo , Kubota Mitsunobu , Matsuura Noriaki , Kuraoka Kazuya , Kinoshita Yasuyuki , Tominaga Atsushi 
Published: April 2023

Abstract
Background
Primary hypothyroidism is a known risk factor for pituitary hyperplasia, which develops symptoms due to compression of the optic chiasm and increased intracranial pressure. As pituitary hyperplasia is known to improve after levothyroxine replacement therapy, there have been no reports of a long clinical course of pituitary hyperplasia due to primary hypothyroidism.
Case presentation
An 18-year-old female presented with headache, double vision and bitemporal hemianopia. A large suprasellar tumor measuring 19.2X13.67X18.96 mm on MRI and the biological testing comprising low thyroid hormone and high TSH levels, and positive thyroid stimulation blocking antibody (TSBAb) were indicative of pituitary hyperplasia due to primary hypothyroidism with TSBAb. For the purpose of ruling out invasive pituitary tumors, the lower one-fourth of the pituitary gland was biopsied and histopathological examination showed pituitary hyperplasia and no malignant findings. A follow-up MRI showed dramatic shrinkage of the pituitary gland after levothyroxine replacement therapy. As pituitary gland size was monitored for approximately 16 years, it did not converge to a normal size.
Conclusions
We describe a case of follow-up over 16 years for pathologically diagnosed pituitary hyperplasia due to primary hypothyroidism with positive TSBAb. Repeated enlargement and shrinkage were confirmed, but observations also suggested the pituitary gland to not always return to normal size after the appearance of profound pituitary hyperplasia. The patient’s non-adherence with levothyroxine intake is likely to cause a profound pituitary enlargement, leading to symptoms due to compression of the optic chiasm and increased intracranial pressure. In the case of poor medication adherence, medication guidance is important to be provided assiduously for the prevention of profound pituitary hyperplasia, while using TSH and PRL levels as indicators.
Interfacial electronic states and self-formed asymmetric Schottky contacts in polar α-In2Se3/Au contacts
Authors: Han Sha , Xia Cai-Juan , Li Min , Zhao Xu-Mei , Zhang Guo-Qing , Li Lian-Bi , Su Yao-Heng , Fang Qing-Long 
Published: April 2023

Abstract
In recent years, the two-dimensional (2D) semiconductor α-In2Se3 has great potential for applications in the fields of electronics and optoelectronics due to its spontaneous iron electrolysis properties. Through ab initio electronic structure calculations and quantum transport simulations, the interface properties and transport properties of α-In2Se3/Au contacts with different polarization directions are studied, and a two-dimensional α-In2Se3 asymmetric metal contact design is proposed. When α-In2Se3 is polarized upward, it forms an n-type Schottky contact with Au, while when α-In2Se3 is polarized downward, it forms a p-type Schottky contact with Au. More importantly, significant rectification effect is found in the asymmetric Au/α-In2Se3/Au field-effect transistor. The carrier transports under positive and negative bias voltages are found to be dominated by thermionic excitation and tunneling, respectively. These findings provide guidance for the further design of 2D α-In2Se3-based transistors.
An Integrated Systems Approach to Decode the Impact of Adolescent Nicotine Exposure in Utero and Postnatally Oxycodone Exposed Offspring
Authors: Flores Adrian , Gowen Austin , Schaal Victoria L. , Koul Sneh , Hernandez Jordan B. , Yelamanchili Sowmya V. , Pendyala Gurudutt 
Published: April 2023

Abstract
Perinatal exposure to prescription opioids pose a critical public health risk. Notably, research has found significant neurodevelopmental and behavioral deficits between in utero (IUO) and postnatal (PNO) oxycodone-exposed offspring but there is a notable gap in knowledge regarding the interaction of these groups to other drug exposure, particularly nicotine exposure. Nicotine's widespread use represents a ubiquitous clinical interaction that current research does not address. Children often experiment with drugs and risky behavior; therefore, adolescence is a key timepoint to characterize. This study employed an integrated systems approach to investigate escalating nicotine exposure in adolescence and subsequent nicotine withdrawal in the IUO- and PNO-offspring. Western blot analysis found alterations of the blood-brain barrier (B.B.B.) and synaptic proteins. RT-qPCR further validated immune dysfunction in the central nervous system (CNS) consistent with compromised B.B.B. Peripheral nicotine metabolism was consistent with increased catabolism of nicotine concerning PNO & IUO, a predictor of greater addiction risk. Lastly, behavioral assays found subtle deficits to withdrawal in nociception and anxiety-like behavior. This study showed, for the first time, the vulnerabilities of PNO- and IUO-exposed groups concerning nicotine use during early adolescence and withdrawal.
It's not just noise: The consequences of inequitable noise for urban wildlife
Authors: Nelson-Olivieri Jasmine , Layden Tamara , Antunez Edder , Khalighifar Ali , Lasky Monica , Laverty Theresa , Sanchez Karina , Shannon Graeme , Starr Steven , Verahrami Anahita , Bombaci Sara 
Published: April 2023

Abstract
Understanding how systemic biases influence local ecological communities is essential for developing just and equitable environmental practices that center both human and wildlife wellbeing. With over 270 million United States residents inhabiting urban areas, understanding the socio-ecological consequences of racially-targeted zoning, such as redlining, will prove critical for urban planning. There is a growing body of literature documenting the relationships between redlining and the inequitable distribution of environmental harms and goods, green space cover and pollutant exposure. However, it remains unknown whether historical redlining impacts the distribution of urban noise or whether inequitable noise drives an ecological change in urban environments. We conducted 1) a spatial analysis of how urban noise corresponds with the distribution of redlining categories and 2) a systematic literature review to summarize the effects of noise on wildlife in urban landscapes. We found strong evidence that noise is inequitably distributed in redlined urban communities across the United States, and that inequitable noise may drive complex biological responses across diverse urban wildlife, reinforcing the interrelatedness of socio-ecological outcomes. These findings lay a foundation for future research that advances relationships between acoustic and urban ecology through centering equity and challenging systems of oppression in wildlife studies.
Structural revolution of PVDF crystallized on nanocarbon surface on a gradient temperature stage and its dielectric properties
Authors: Li Shuhui , Wang Hai , Liang Xiaobin , Qu Meijie , Fan Mingshuai , Zhang Rui , Nakajima Ken , Bin Yuezhen 
Published: April 2023

Abstract

Poly (vinylidene fluoride) (PVDF) has been widely concerned because of its various transformations of crystal phase as well as its special dielectric, piezoelectric, and other electrical properties. In this paper, the temperature gradient (T-gradient) was constructed for studying the temperature dependence of crystallization behavior of PVDF and the heterogenous nucleation effect of multiwall carbon nanotubes (MWCNT) and graphene nano-platelets (GN). The aggregate structure, the change content of PVDF conformation, and the influence of heterogenous nucleating agent on the crystallization behavior of PVDF formed at different crystallization temperature (Tc) were investigated through three different dimensions by using FTIR for surface, WAXD/SAXS for bulk and AFM for cross-section respectively. The results showed that the low temperature and heterogenous nucleating agent were both conductive to the formation of γ phase of PVDF. The content of γ phase reached to 77% when Tc was lower than 61 ℃, and the proportion of γ (021) peak increases from 1.7–7.0% when PVDF crystallized at Tc =117 ℃ induced by MWCNT-rich. And the high density of nucleus and low Tc lead to the lower lamellar thickness and lower crystallite size. Higher content and lower crystallite size of γ phase leads to higher dielectric constant. The dielectric constant of sample crystallized at 61 ℃ which was induced by GN was significantly increased up to 6.2 which can lay a foundation for its future application in the field of dielectric.
North Atlantic Subpolar Gyre Provides Downstream Ocean Predictability
Authors: Fan Hongdou , Borchert Leonard , Brune Sebastian , Koul Vimal , Baehr Johanna 
Published: April 2023

Abstract
It has been hypothesized that North Atlantic subpolar gyre (SPG) exerts substantial influence on climate predictability. However, a clear identification of the downstream impact of SPG variations is still lacking. Using MPI-ESM-LR1.2 decadal prediction system, we show that along the Atlantic water pathway, a dynamical link to the SPG causes salinity to be considerably better predicted than temperature. By modulating slow northward ocean propagation, the memory of SPG variations in subsurface salinity causes salinity to be skillfully predicted up to 8 years ahead. In contrast, SPG loses influence on temperature before Atlantic water penetrates into the Nordic Seas, where temperature is only predicted up to 2 years ahead. This study identifies the key role of SPG signals in downstream prediction and highlights how SPG signals determine prediction time scales for different quantities, opening the door for investigating multiple quantities in the subarctic for earth system prediction research.
Ensemble of BLUP, Machine Learning, and Deep Learning Models Predict Maize Yield Better Than Each Model Alone
Authors: Kick Daniel Robert , Washburn Jacob Daniel 
Published: April 2023

Abstract
Predicting phenotypes accurately from genomic, environment, and management factors is key to accelerating the development of novel cultivars with desirable traits. Inclusion of management and environmental factors enables in silico studies to predict the effect of specific management interventions or future climates. Despite the value such models would confer, much work remains to improve the accuracy of phenotypic predictions. Rather than advocate for a single specific modeling strategy, here we demonstrate within large multi-environment and multi-genotype maize trials that combining predictions from disparate models using simple ensemble approaches most often results in better accuracy than using any one of the models on their own. We investigated various ensemble combinations of different model types, model numbers, and model weighting schemes to determine the accuracy of each.
We find that ensembling generally improves performance even when combining only two models. The number and type of models included alter accuracy with improvements diminishing as the number of models included increases. Using a genetic algorithm to optimize ensemble composition reveals that, when weighted by the inverse of each model’s expected error, using combinations of best linear unbiased predictors, linear fixed effects models, deep learning models, and select machine learning models perform best on our datasets.
Experimental study on the influence of longitudinal slope on airflow-dust migration behavior after tunnel blasting
Authors: Hu Hui , Tao Yuchun , Zhang Heng , Zhao Yiqi , Lan Youdi , Ge Zhenghui 
Published: April 2023

Abstract
In this paper, a 1:21 model experiment was conducted to discuss the dust dispersion efficiency and liner trolley obstruction effect inside the tunnel at -9° to 9°, the effect of different initial dust concentrations on dust dispersion and liner trolley obstruction effect at 6° slope, and the effect of different return air velocity on dust dispersion at 6° slope. The results show that as the slope of the tunnel changes from 0° to -9°, the average dust dispersion time decreases by 3.7% at the working face and the dust concentration difference between the front and rear of the trolley is improved by 2.7%. When the slope of the tunnel changes from 0° to -9°, the average dust dispersion time increases by 7.2% at the working face and the dust concentration difference between the front and rear of the trolley is improved by 17.9%. With each 100mg/m3 increase in the initial dust concentration, the dust dispersion time at the working face and the tunnel exit increases by 9.15% and 8.17% on average, and the lining trolley obstruction time increases by 23.33s on average. The dust dispersion times take an average reduction rate of 15.7%, with the increase of return air velocity. The recommended return air velocity is greater than 1m/s for large slope tunnels. When the slope changes from 0°to 9°, the hindrance rate of slope on dust dispersion is 2.88462%, 8.65385%, and 16.34615% respectively. Dust dispersion efficiency will be reduced as the tunnel slope changes from 0°to 9°, The growth rate of slope on dust dispersion is -0.96154%, -2.88462%, and -6.73077% respectively.
Apple pest and pathogen reduction in landscapes with large patch size and small area of orchards: a national-scale analysis
Authors: Etienne Lucas , Franck Pierre , Rusch Adrien , Lavigne Claire 
Published: April 2023

Abstract
Context
: The composition and configuration of habitats in agricultural landscapes may determine crop damage resulting from pests or pathogens either by directly affecting their population dynamics or through indirect effects on their natural enemies.
Objectives
The aim of this study was to assess the impact of landscape composition and configuration on the occurrence and damage caused by the codling moth and apple scab in apple orchards.
Methods
Using monitoring data at the French national scale, we examined how the proportion of landscape area grown with orchards the mean patch area of orchards the share of organic orchards and the proportion of woodlands and grasslands affected the occurrence and damage of these two pests from 2015 to 2019 in approximately sixty apple orchards each year.
Results
Landscapes with a higher proportion of orchards supported a higher occurrence of apple scab and earlier colonisation of codling moths. In addition, we found that codling moth damage decreased with increasing orchard patch area in the landscape. The proportion of seminatural habitats or organic farming in the landscape never significantly explained pest occurrence or damage.
Conclusions
Our results clearly highlight the importance of considering the amount and spatial arrangement of the pests’ and pathogens’ host crops to understand their infestation levels. Our study calls for the territorial management of orchard distribution to limit pesticide use in apple orchards.
Sperm-fluid-cell interplays in the bovine oviduct: glycosaminoglycans modulate sperm binding to the isthmic reservoir
Authors: Mahé Coline , Pranomphon Thanya , Reynaud Karine , Laffont Ludivine , Meylheuc Thierry , Schoen Jennifer , Mermillod Pascal , Saint-Dizier Marie 
Published: April 2023

AbstractWhen entering the oviduct for fertilisation, spermatozoa come into contact with the oviduct fluid (OF) and can bind to luminal epithelial cells in the isthmus to form a sperm reservoir. The objective of this study was to examine how the OF modulates sperm adhesion to the oviduct reservoir using anin vitromodel of oviduct epithelial spheroids (OES). Bovine oviducts from a local slaughterhouse were used to collect OF and isthmic fragments for thein vitroculture of OES. Compared to a non-capacitating control medium, the pre-ovulatory OF significantly decreased by 80–90% the density of spermatozoa bound to OES without affecting sperm motility, membrane integrity, or sperm-cilia interactions. This effect on sperm binding was reproduced with (i) OF from different cycle stages and anatomical regions of the oviduct; (ii) OF fractions of more than 3 kDa; (iii) modified OF in which proteins were denatured or digested and (iv) heparan sulphate but not hyaluronic acid, two glycosaminoglycans present in the OF. In conclusion, the OF prevented a sperm subpopulation from binding to oviduct epithelial cells without affecting sperm motility and this effect was due to macromolecules, including heparan sulphate.