bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the efficacy of Sufentanil and Morphine Titration for patient-controlled Subcutaneous Analgesia in severe advanced cancer pain
Authors: Liu Dong , Li Wei , Chen Li 
Published: January 2023

Objective: To compare the efficacy and side effects of sufentanil and morphine titration for patient-controlled subcutaneous analgesia (PCSA) in severe advanced cancer pain management.
Methods: A retrospective analysis was performed on the patients who were treated by two cancer centers with PCSA for severe advanced cancer pain at the Fourth Hospital of Hebei Medical University and Baoding No.1 Hospital between 2018 and 2021. These patients were divided into a sufentanil group and a morphine group. The drug dosage of the two groups was recorded. The pain intensity, sleep quality and adverse event rate (AER) were compared and analyzed between the two groups.
Results: PCSA was successful in 95.2% (120/126) of the patients. In all cases, titration was successful within 24 hour, followed by oral administration of sustained-release opioid medications at 208.4 ±75.1 mg in the sufentanil group and at 207.9±66.3 mg in the morphine group. There was a significant difference in pain intensity and sleep quality before and after titration (P <0.05). Both groups exhibited a decline in their heart rates during titration. Compared with the baselines before titration, the mean heart rates were significantly reduced in both groups (P <0.05). The sufentanil group had an AER lower than that of the morphine group.
Conclusion: Short-term use of sufentanil supports PCSA for patients with severe advanced cancer pain can achieve effective and rapid pain management, it is worth clinical implementation and application.
doi: https://doi.org/10.12669/pjms.39.2.6664
How to cite this: Liu D, Li W, Chen L. Comparison of the efficacy of Sufentanil and Morphine Titration for patient-controlled Subcutaneous Analgesia in severe advanced cancer pain. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6664
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Effects of body mass index on propofol-induced cardiovascular depression in the Pakistani population
Authors: Naeem Uzma , Waheed Akbar , Azeem Yasmeen , Awan Nazir 
Published: January 2023

Objective: To determine the relationship between the patient’s Body Mass Index (BMI) and the cardiovascular effects produced by propofol at a dose of 1.5 mg/kg in the Pakistani population.
Methods: This descriptive cross-sectional study was conducted in the Holy Family Hospital Rawalpindi from August 2021 to January 2022. According to their BMI, one hundred twenty Pakistani individuals 18 to 60 years of age were equally divided into three groups. Group N (n = 40) with a BMI of 18 to 24.9, group OW (n=40) with a BMI of 25 to 29.5, and group O (n=40) with a BMI of 30 to 34.9 were randomized to receive propofol injections at a 1.5 mg/kg dose for induction of anesthesia. We measured mean blood pressure before the propofol and then at one, three, and ten minutes after the injection. Data were analyzed by using SPSS 22.
Results: Mean blood pressure decreases significantly in all groups, as shown by p-values of <0.001 for the first two readings. In group N, blood pressure returned to near normal within ten minutes (p-value 0.061), but in groups, OW and O, mean blood pressure was significantly lower even after ten minutes (p-values 0.005 and 0.001, respectively). Individual variations in propofol response were also observed.
Conclusion: In the Pakistani population, propofol at an induction dose of 1.5 mg/kg to patients with different body weights produces cardiovascular effects with marked standard deviations in each group, which indicate different individual responses.
Clinical Trial Number: NCT05383534 https://register.clinicaltrials.gov/
doi: https://doi.org/10.12669/pjms.39.2.6787
How to cite this: Naeem U, Waheed A, Azeem Y, Awan MN. Effects of body mass index on propofol-induced cardiovascular depression in the Pakistani population. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6787
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Correlation analysis of Blood TM, TG and D-dimer with deep venous Thrombosis formation in patients after Total Hip Arthroplasty
Authors: Luo Hailin , Qiao Yong 
Published: January 2023

Objective: To explore the correlation of blood thrombomodulin (TM), triglyceride (TG) and D-Dimer (D-D) with the formation of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA).
Methods: A retrospective analysis was carried out focusing on the clinical data of 150 patients with THA who were admitted to Sichuan Provincial Orthopedic Hospital from May 2019 to May 2022 (the study group). These patients were then subdivided into Group-A (46 cases with DVT) and Group-B (104 cases without DVT) according to whether DVT occurred after an operation. Meanwhile, another 70 patients who received physical examination in this hospital in the same period were selected as the control group. Furthermore, the levels of TM, TG, D-D, fibrinogen (Fb) and C-reactive protein (CRP) were compared between the groups. Pearson correlation was used to analyze the relationship between the levels of TM, TG, D-D, Fb, CRP and the formation of DVT.
Results: The levels of TM, TG, D-D, Fb and CRP in the study group were significantly higher than those in the control group (p<0.05). The above indicators in Group-A were higher than those in Group-B one day after the operation (p<0.05). Pearson correlation analysis showed that the levels of TM, TG, D-D, Fb and CRP were significantly positively correlated with the formation of DVT.
Conclusion: Patients with DVT after THA show an increase in the levels of TM, TG, D-D, Fb and CRP, indicating their diagnostic value for the formation of DVT. Findings in our study suggest that clinical tests of these indicators can be carried out according to the actual situation of patients.
doi: https://doi.org/10.12669/pjms.39.2.6989
How to cite this: Luo H, Qiao Y. Correlation analysis of Blood TM, TG and D-dimer with deep venous Thrombosis formation in patients after Total Hip Arthroplasty. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6989
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparative analysis of health authorities’ spokespersons and health influencers during the COVID-19 pandemic
Authors: Nurlaela Arief N. , Pratama Andika Putra , Amalia Hasta Barata Vinka , Lathifah Tirdasari Nyayu , Budiman Dicky 
Published: January 2023

Background: Concerns over an infodemic following a surge in health misinformation circulating on social media set out the government's priority for Indonesia. Given the urgent work on the coronavirus disease 2019 (COVID-19) response, the government collaborated with health-related spokespersons and influencers with a medical background by starting a COVID-19 public education campaign on social media. A collaborative initiative involved health spokespersons from government and non-government to clarify misinformation about COVID-19. Methods: The primary purpose of this research is to compare government and non-government spokespersons by examining their roles in educating about COVID-19 vaccines and health services. This study employed comparative factor analysis and non-participatory observation toward the media activity of spokespersons in Indonesia. Using a questionnaire, this study examined the dimensions of public campaigns, risk communication, health and emergency, leadership and communication from Indonesian spokespersons. The data collection was conducted in two stages: a pilot study involving 102 respondents and the actual study involving 276 respondents. Results: Findings show that utilizing spokespersons is important due to its capabilities of reaching diverse audiences and improving public engagement, trustworthiness, and credibility. Conclusions: Combining health authorities’ spokespersons and health influencers in Indonesia, this study provides valuable insights for communication management in developing and supporting the role of health authorities from the government, non-government as well as medical sectors.
Ratzinger ante el conflicto entre ciencia y fe
Authors: Collado Santiago 
Published: January 2023

Este trabajo aborda la contribución de Ratzinger al debate sobre la relación entre ciencia y fe. No la analizamos desde los esquemas usuales que clasifican dicha relación en modelos como el del conflicto, magisterios independientes, integración, etc. La posición de Ratzinger se encuadra mejor en un esquema que clasifica las diferentes actitudes adoptadas ante la tesis del conflicto. Proponemos una clasificación de dichas actitudes.
Mostramos cómo Ratzinger reconoce la existencia de un conflicto real en la relación entre ciencia y fe. Exponemos las raíces epistémicas que, según Ratzinger, dan lugar a dicho conflicto y denominamos su actitud ante el mismo de “armonización”. La tarea de armonización propuesta por Ratzinger es posible mantenerla sólo desde la fe. Se trata de una fe entendida de manera distinta al modo en que comparece en los modelos de relación antes mencionados y que usualmente se presentan como modelos alternativos. La propuesta de Ratzinger sirve para dar unidad a dichos modelos. No aborda el conflicto desde los presupuestos ilustrados, sino desvelando las claves epistémicas que determinan su naturaleza y que se descubren en un proceso histórico del que nuestro autor dibuja un cuadro global.
En Ratzinger el conflicto se entiende mejor como tensión insuperable que invita a acometer una tarea continuada de purificación. El sujeto de dicha purificación son las imágenes con las que se ha expresado la fe a lo largo de la historia y las cosmovisiones en las que dicha fe ha sido acogida, las que le han prestado esas imágenes.
Minimum Wage Increases and Employer Performance: Role of Employer Heterogeneity
Authors: Agarwal Sumit , Ayyagari Meghana , Kosová Renáta 
Published: January 2023

Despite a large minimum wage literature that analyzes employee outcomes, there is less evidence on firm performance, prices, and quality. Exploiting staggered changes in U.S. minimum wages during 2000–2008 and census data on more than 29,000 hotel properties, we find that doubling the minimum wage as currently debated would reduce average hotel revenues by 6% per year and their occupancy rates by 3.1%. Responses vary by employer quality and organizational form. Although luxury hotels pass through cost increases to their customers with no impact on their revenues, upscale hotels facing more price-sensitive customers reduce prices but still suffer losses in occupancy rates and revenues as they struggle with preserving the expected quality level. They are also most likely to see quality downgrades from their segment. The lower-end hotels also pass through cost increases to their customers but, unlike luxury hotels, face significant declines in occupancy rates and revenues. Overall, the performance effects of minimum wage increases are nonmonotonic across quality. We also find negative impacts on hotel entry rates, although the performance and entry effects appear to be short lived. Furthermore, the negative effects of minimum wages dominate in states without right-to-work regulation, suggesting the need for a more comprehensive approach to labor market regulation. This paper was accepted by Victoria Ivashina, finance. Funding: M. Ayyagari received financial support from National Science Foundation Research (U.S) [Grant SES-1660755/1660749]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.4650 .
Believing in Analytics: Managers’ Adherence to Price Recommendations from a DSS
Authors: Caro Felipe , de Tejada Cuenca Anna Sáez 
Published: January 2023

Problem definition: We study the adherence to the recommendations of a decision support system (DSS) for clearance markdowns at Zara, the Spanish fast fashion retailer. Our focus is on behavioral drivers of the decision to deviate from the recommendation, and the magnitude of the deviation when it occurs. Academic/practical relevance: A major obstacle in the implementation of prescriptive analytics is users’ lack of trust in the tool, which leads to status quo bias. Understanding the behavioral aspects of managers’ usage of these tools, as well as the specific biases that affect managers in revenue management contexts, is paramount for a successful rollout. Methodology: We use data collected by Zara during seven clearance sales campaigns to analyze the drivers of managers’ adherence to the DSS. Results: Adherence to the DSS’s recommendations was higher, and deviations were smaller, when the products were predicted to run out before the end of the campaign, consistent with the fact that inventory and sales were more salient to managers than revenue. When there was a higher number of prices to set, managers of Zara’s own stores were more likely to deviate from the DSS’s recommendations, whereas franchise managers did the opposite and showed a weak tendency to adhere more often instead. Two interventions aimed at shifting salience from inventory and sales to revenue helped increase adherence and overall revenue. Managerial implications: Our findings provide insights on how to increase voluntary adherence that can be used in any context in which a company wants an analytical tool to be adopted organically by its users. We also shed light on two common biases that can affect managers in a revenue management context, namely salience of inventory and sales, and cognitive workload. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2022.1166 .
Palliative care nursing during the COVID-19 pandemic: reflections from Melbourne, Australia
Authors: King Meredith A , Yoong Jaclyn 
Published: January 2023

Background: Nurses played a critical role in providing care for patients throughout the COVID-19 pandemic. Aim: This study aimed to explore perspectives of Australian palliative care nurses regarding the impact of COVID-19 on the provision of care for patients with advanced illness, or at the end of life. Methods: The authors conducted a survey of palliative care nurses in ward- and consultation-based roles at a metropolitan health service in Victoria, Australia. Findings: A total of 24 out of 39 nurses completed the survey. Responses included strong themes of fear of COVID-19 and sadness about separating dying patients from their families. Conclusion: Delivery of palliative care changed at an individual and service level. Importantly, there were strong themes of adapting to change and ‘soldiering on’ with the core business of palliative care.
Root resorption: why we all need to get informed consent
Authors: Roshanray Fatemeh , Sandler Cara , Sandler PJ 
Published: January 2023

Severe root resorption is a rare, but serious, complication of orthodontic treatment, which can affect the long-term prognosis of the teeth affected. This case presents a young, healthy patient with severe root resorption affecting nearly all of her dentition. It was an incidental finding by her GDP 8 months after completion of her orthodontic treatment. The article aims to raise awareness about the importance of obtaining a valid consent at the start of each orthodontic treatment, and highlight the possible risk factors associated with severe root resorption, diagnostic methods, and interventions to prevent or manage it when it occurs. CPD/Clinical Relevance: Although developing severe root resorption as a result of orthodontic treatment is relatively uncommon, the consequences are serious. This article highlights the importance of identifying high-risk orthodontic patients, where possible, and obtaining valid, informed consent prior to every course of orthodontic treatment.
Non-surgical management of a traumatic mid-palatal suture diastasis by novel use of an orthodontic appliance
Authors: Duggal Simone , Jenkins Fiona , Littlewood Simon , Siddique Ibraz 
Published: January 2023

Sutures are formed during embryonic development at the sites of approximation of the membranous bones of the craniofacial skeleton. They afford major sites of bone expansion during postnatal craniofacial growth, and also influence facial fracture patterns through offering a path of least resistance to force. There are some studies that have shown that the mid-palatal suture (MPS) fuses at 11–13 years and 14–16 years in females and males, respectively. This means that during childhood, the suture is open; thus force applied to the palate at this time tends to split the bone in the midline between the two unfused palatal shelves. The understanding of this biological process allows orthodontists to correct transverse growth discrepancies of the maxilla. Various appliances, including the hyrax appliance, can be used to allow rapid maxillary expansion (RME) by expanding the suture. Paradoxically, the same appliance can be used to allow rapid maxillary contraction (RMC) by contracting the suture. This method of application using a hyrax appliance is rare. We present a case report where this method of application allowed closure of a traumatic mid-palatal suture diastasis, correction of a traumatic transverse discrepancy of the maxilla and avoided an invasive surgical intervention in a 15-year-old male. CPD/Clinical Relevance: This article highlights the importance of considering a patient's age and anatomical development when exploring treatment options. It is prudent to take advantage of this to enhance the natural biological healing process.
Early removal of supernumeraries to close a midline diastema: a case report
Authors: Brooks Laura , Smorthit Kelly , Sandler Jonathan 
Published: January 2023

A midline diastema is a part of normal dental development, which, in the mixed dentition, is termed the ‘ugly duckling’ stage. Supernumerary teeth, however, can also be a cause, with the most common type being a mesiodens. Supernumeraries can cause other complications including delayed or failure of eruption of a permanent tooth, displacement of crowns, crowding, root resorption and cyst formation. Treatment options for supernumeraries include immediate or delayed removal or active monitoring. This article advocates for early diagnosis and treatment to reduce the need for future complex treatment. CPD/Clinical Relevance: This case emphasizes the importance for clinicians to accurately and carefully diagnose the cause of a midline diastema and the presence of supernumerary teeth early in development. Prompt orthodontic referral can reduce the need for later complex surgical and orthodontic treatment.
Emissions of Greenhouse Gases and Ammonia From a Wheat Site Under Intensive Management Affected by Different Fertilization Practices
Authors: Zhou Zhongkai , Zhang Siyu , Jiang Na , Zhang Haifang , Wang Lili , Xiu Weiming , Zhao Jianning , Yang Dianlin 
Published: January 2023

HighlightsThe recommended mineral fertilizers plus organic fertilizer treatments increased the soil total carbon (TC) and nitrogen (TN) levels.The application of organic fertilizer markedly reduced the loss of NH3-N compared to the application of mineral nitrogen alone.CO2 and N2O emissions from the application of organic fertilizer were higher than those from the application of mineral nitrogen under long-term fertilization.Abstract. Greenhouse gas (GHG) and ammonia (NH3) emissions from wheat fields have been a serious challenge to agriculture and the environment. The integration of the use of inorganic N fertilizer, organic fertilizer, and crop residues and their environmental effects is needed under conventional tillage. In situ field experiments were established to evaluate the impact of different fertilization practices on soil greenhouse gas and ammonia emissions from a winter wheat field. A fertilizer experiment was performed from 24th October 2019 to 11th June 2020 in a winter wheat (Triticum aestivum L.) field in China with six fertilization treatments: (1) unfertilized control (UC); (2) recommended mineral fertilizer application of 200 kg ha-1 N (RF); (3) RF plus 15 t ha-1 of organic fertilizer (RFLO); (4) RF plus 30 t ha-1 of organic fertilizer (RFMO); (5) RF plus 45 t ha-1 of organic fertilizer (RFHO); and (6) traditional mineral fertilizer application of 300 kg ha-1 N (TF). The results showed that the RF plus organic fertilizer treatments increased the soil organic total carbon (TC) and nitrogen (TN) levels. Under long-term fertilization, the CO2 emissions from the RFLO, RFMO, and RFHO treatments were 18.3, 19.9, and 20.0 t ha-1, respectively, compared with those from the RF and TF treatments (13.2 and 16.0 t ha-1, respectively). In addition, the N2O emissions from the organic-inorganic fertilizer treatment were 7.6 kg ha-1 for the RFLO treatment, 12.4 kg ha-1 for the RFMO treatment, and 8.1 kg ha-1 for the RFHO treatment, which were higher than those from the RF and TF treatments (3.1 and 5.6 kg ha-1, respectively). The NH3 emissions from the RFLO, RFMO, and RFHO treatments (17.3, 26.2, and 22.4 kg ha-1, respectively) were lower than those from the RF (31.2 kg ha-1) and TF (49.7 kg ha-1) treatments under long-term fertilization. The methane emission potential of organic-inorganic fertilizer applications was 27.0% to 98.5% higher than a single application of inorganic fertilizer. Keywords: Ammonia, Carbon dioxide, Fertilization management, Nitrous oxide, Organic fertilizers, Winter wheat.