bluuebunny/crossref_metadata_2025_split huggingface dataset:
Density of the level sets of the metric mean dimension for homeomorphisms
Authors: Acevedo Jeovanny de Jesus Muentes , Ibarra Sergio Augusto Romaña , Cantillo Raibel de Jesus Arias 
Published: February 2023

Abstract
Let N be an n-dimensional compact riemannian manifold, with n ≥ 2. In this paper, we prove that for any α ϵ 2 [0, n], the set consisting of homeomorphisms on N with lower and upper metric mean dimensions equal to α is dense in Hom(N). More generally, given α, β ϵ [0; n], with α ≤ β , we show the set consisting of homeomorphisms on N with lower metric mean dimension equal to α and upper metric mean dimension equal to β is dense in Hom(N). Furthermore, we also give a proof that the set of homeomorphisms with upper metric mean dimension equal to n is residual in Hom(N).
Hydrogeochemical characterization of ground and surface water in the Eastern part of the Adamawa-Yade Domain, Bertoua-Cameroon
Authors: Nelson MentiAgbor , Wotany Engome Regina , Agyingi Christopher , Wirmvem Mengnjo Jude , Jude Ngai N 
Published: February 2023

Abstract
Groundwater and surface water are major sources of water supply to the inhabitants of Bertoua. Hydrogeochemical study was conducted in the study area aimed at identifying the processes that control the chemistry of groundwater sources and to examine the quality of the water sources fordomestic and agricultural purposes. Fifty water samples were collected from boreholes, open wells, springs, and rivers within the study area in January 2022 (the dry season). The samples were analyzed for physicochemical characteristics including pH, electrical conductivity (EC), total dissolved solids(TDS) and major ions. The water samples were acidic with 94% of pH values less than 6.5. The EC varied from 21-776 µS/cm and TDS (8.5-388 mg/l).The low EC and TDS indicate low mineralization and fresh water. The relative abundance of major ions (meg/l) was Ca2+> Mg2+> K+>Na+ for cations and HCO3- >CL->NO3>SO4-for anions. These major ions concentrations were low and within the WHO guideline values for drinking water. From Piper diagram two dominant water facies were observed; Ca-Cl and CaHCO3 with some samples plotting in mixed CaMgCl. Rock-water interaction, ion exchange, silicate weathering and anthropogenic activities were the processes responsible for the groundwater chemistry with some minor evaporative effects. These major ions concentrations were low and within the WHO guideline values for drinking water.Based on Sodium Adsorption Ratio and Residual Sodium Bicarbonate all samples fall in the excellent category for agriculture.
Symptoms and prognoses of patients with end-stage fungating breast cancer in palliative care units: the multicentre, prospective, observational EASED study
Authors: Takeda Yuma , Ishiki Hiroto , Oyamada Shunsuke , Otani Hiroyuki , Maeda Isseki , Yamaguchi Takashi , Hamano Jun , Mori Masanori , Morita Tatsuya 
Published: February 2023

Abstract
Purpose: We investigated the symptoms and prognoses of patients with fungating breast cancer in the palliative care unit setting.
Methods: This study was a sub-group analysis of a multicentre, prospective, observational study. Patients admitted to 23 palliative care units in Japan between January and December 2017 were enrolled. Data of patients with breast cancer were extracted. Wecompared demographic characteristics, symptoms, and prognoses by breast cancer skin lesion status. The primary outcome was overall survival. Secondary outcomes included Palliative Prognostic Index (PPI) score, details about skin lesions, and symptom burden.
Results:Of 1,896 patients, 131 (6.9%) had breast cancer. In this cohort, 44 (33.6%) patients had skin lesions. Most skin lesions (88%) were on the backand chest. Some skin lesions were associated with skin redness, erosion, necrosis, or fistula. Symptoms included bleeding, exudate, odour, and pain. Twenty-eight patients (63.6%) needed dressing changes and 14 (31.8%) patients experienced bleeding. None died due to bleeding.
In the skin lesion group, 32 (72.8%) patients had used opioids equivalent to 38 mg of oral morphine daily, compared to 25 mg in 57 (65.5%) in the non-skin lesion group (p = 0.26). Median PPI scores at hospital admission were 4.5 versus 6.5 (p = 0.08). Median survival was 23 versus 21 days (p = 0.48).
Conclusion: Patients with skin lesions had a distinct symptom burden and tended to use a higher dose of opioids. The effect of skin lesions on survival was unclear.
The ϵ-spectral radii of k-uniform hypertrees *
Authors: Li Weimin , Li Jianping , Zhang Jianbin , He Weihua 
Published: February 2023

Abstract
The \epsilon-spectral radius of a connected hypergraph is the largest eigenvalue of its eccentricity matrix. Let \mathcal{T}_{m,d} be the set of k-uniform hypertrees with size m and diameter d. In this paper, we show that the eccentricity matrix of a k-uniform hypertree is irreducible, and we characterize the unique hypertrees with the minimum-spectral radius among \bigcup_{d\neq3}\mathcal{T}_{m,d}.
AMS Classi cation: 05C50, 05C65
Combination of vonoprazan and amoxicillin as the first-line Helicobacter pylori eradication therapy: a multicenter, prospective, randomized, parallel-controlled study
Authors: Peng Xiang , Chen Huang-wei , Wan Yu , Su Pei-zhu , Yu Jin , Liu Jun-jun , Lu Yi , Zhang Min , Yao Jia-Yin , Zhi Min 
Published: February 2023

Abstract
Background
The eradication rate of Helicobacter pylori (H. pylori) decreased gradually. This study aimed to analyze the efficacy and safety of a 14-day combination of vonoprazan and amoxicillin as the first-line eradication therapy for H. pylori infection, and compared them with those of the bismuth quadruple therapy.
Methods
A prospective randomized clinical trial (RCT) was designed, involving patients with H. pylori infection in 6 institutions who did not receive any treatment yet. They were randomly assigned into VA-dual group (vonprazan 20mg b.i.d + amoxicillin 750mg q.i.d) or EACP-quadruple group (esomeprazole 20mg + amoxicillin 1000mg + clarithromycin 500mg + colloidal bismuth subcitrate 220mg b.i.d) for 14 days in ratio of 1:1. At least 28 days later, the eradication rate were detected by the 13C-urea breath test (UBT).
Results
A total of 562 patients from February 2022 to September 2022 were enrolled and 316 were randomly. In the ITT analysis, the eradication rates of H. pylori in VA-dual group and EACP-quadruple group were 89.9% and 81.0% respectively, p = 0.037. In the PP analysis were 97.9% and 90.8%, p = 0.009. The different eradication rate was 8.9% (95%CI, 1.2–16.5%) and 7.2% (95%CI, 1.8–12.4%) in ITT and PP analysis, both lower limit of the 95%CI was still higher than the prespecified margin. In addition, the incidence of adverse events in VA-dual group was significantly lower than that in EACP-quadruple group (19.0% vs. 43.0%, P < 0.001).
Conclusion
The efficacy and safety of a 14-day combination therapy of vonoprazan and amoxicillin in eradicating H. pylori are superior to bismuth quadruple therapy, and this combination significantly reduces the use of antibiotics.
Structure and Dynamics of Tetrhis, a Novel Metal-dependent Polyhistidine Tetramerization Motif
Authors: Healey Robert , Couillaud Louise , hoh francois , Mouhand Assia , Granier Sebastien , Leyrat Cedric 
Published: February 2023

Abstract
The polyhistidine (6XHis) tag is one of the most ubiquitous fusion tags used for the purification of recombinant proteins. The 6XHis motif enables the tagged protein to bind metal ions such as Co2+, Ni2+, Zn2+ and Cu2+, which can be advantageously used for protein purification with immobilized metal affinity chromatography (IMAC). Despite its widespread use, high-resolution protein structures encompassing a metal-bound 6XHis motif rarely occur in the worldwide Protein Data Bank (PDB). Here, we obtained a 2.5 Å resolution crystal structure of a single chain variable fragment (scFv) antibody bearing a C-terminal tag composed of a sortase motif (LPETG), followed by a 6XHis and a TwinStrep tag (WSHPQFEK[G3S]3WSHPQFEK). The protein crystallized in the presence of cobalt (II) and its structure reveals a novel tetramerization motif (TetrHis) stabilized by 8 Co2+ ions clustered within a small region of space. The TetrHis motif contains two 6 residues-long β-strands related by a twofold symmetry axis, and the 8 metal centers coordinate 3 to 5 protein residues each, including all of the 6XHis histidines, a glutamate residue from the sortase motif and an additional histidine residue from the TwinStrep tag. We reviewed metal-bound homopolymeric histidine tracts in deposited PDB structures and found no similar motifs. Using a combination of small angle x-ray scattering (SAXS), molecular dynamics (MD) simulations and ensemble analysis, we studied the structural dynamics of the tagged scFv in the absence and presence of Co2+ ions, demonstrating an open/close equilibrium of the monomer and the formation of a cobalt-stabilized tetramer in solution. The structure of the novel metal-dependent tetramerization motif reported here might provide a useful starting point for designing metal-loaded biomaterials, with potential applications in the fields of biosensors, bioanalytical devices, or biocatalysts.
A modified Hammerstein modeling by the differential evolution algorithm
Authors: Chang Wei-Der 
Published: February 2023

Abstract

This paper focuses on the nonlinear system modeling based on using a modified Hammerstein system model. The proposed Hammerstein structure is composed of a bilinear neural network (BNN) and a recursive digital system in the cascaded form. The former is taken to be the nonlinear function part of the Hammerstein model, and the latter is used as the linear dynamic subsystem. The BNN is then constructed by the bilinear digital system and the recurrent neural network, which already possesses a satisfactory modeling capacity. To update all the adjustable parameters within the proposed Hammerstein model, a popular and powerful evolutionary computation called the differential evolution (DE) is utilized so that the model output can be very close to the actual nonlinear system output. Finally, a simulated nonlinear chemical process system, continuously stirred tank reactor (CSTR), is illustrated with the modeling phase and testing phase. Some numerical results as compared with a different method from subject literature are provided to show the feasibility of the proposed method and its good modeling.
Role of regulatory monitoring in the Indian Oil and Gas Sector for Risk Reduction
Authors: Tata LN Murthy , Salwan Prashant 
Published: February 2023

Abstract
OALP was introduced in 2016 by GoI with a less regulatory burden to the government and pricing freedom to investing firms. Earlier policy NELP was with exploration and production cost recovery and price control by GoI. The new policy OALP is with no-cost recovery, revenue sharing, and pricing freedom to the firm. The Oil and gas industry is involved with a wide variety of risks. In OALP, there is no regulatory monitoring and no cost recovery; this has increased the risk to the Indian oil and gas industry; a firm may go for cheap alternatives, which can cause accidents and create direct loss to the industry and the country's reputation. In addition, pricing freedom for the firm can increase the natural gas price, and the gas-dependent sectors face trouble in purchasing. This paper studied the role of regulatory monitoring in risk reduction in the Indian oil and gas sector
Test Generation Algorithm for Quantum-dot Cellular Automata (QCA) Technology
Authors: Dhare Vaishali , Mehta Usha 
Published: February 2023

Abstract
One of the alternatives to the current silicon technology, Complementary Metal Oxide Semiconductor (CMOS) is Quantum-dot Cellular Automata (QCA). Test generation is an unavoidable process in the CMOS design flow. This possibility of test generation must be explored and applied to the QCA as the QCA is a novel and nanoscale technology. Therefore, in this paper, the test generation process is explored and implemented for QCA combinational circuits.
The FAN (A Fanout Oriented) Automatic Test pattern Generator (ATPG) algorithm is extended for QCA (FANQ). The proposed FANQ ATPG is developed for faults caused by Multiple Missing Cells (MMC) along with single missing cell defect in QCA primitives and circuits which is not reported in earlier QCA based ATPG. The previously proposed testing properties and testability measures are incorporated in the FANQ ATPG for its effectiveness. The generated test vectors are compacted and tested on previously synthesized, QCA-oriented Microelectronics Center for North Carolina (MCNC) benchmark circuits. Further, the generated test vectors are also validated at the layout level to demonstrate the correctness of ATPG. The proposed ATPG for QCA combinational circuits required fewer test vectors for the stuck at fault model compared to the available QCA ATPG.
Membrane Protein Bcest Is Involved in Hyphal Growth, Virulence and Stress Tolerance of Botrytis cinerea
Authors: Zhang Wei , Ge Beibei , Lv Zhaoyang , Li Hua , Park Kyung Seok , Shi Liming , Zhang Kecheng 
Published: February 2023

Abstract
Grey mold caused by Botrytis cinerea is a devastating disease responsible for large losses to agricultural production, and a necrotrophic model fungal plant pathogen. As important targets of fungicides, membrane proteins are hot spots in the research and development of fungicide products. Wuyiencin affects the permeability and pathogenicity of B. cinerea, and the membrane protein Bcest was found to be associated by parallel reaction monitoring. To explore this relationship, the bacteriostatic mechanism of wuyiencin was elucidated. In the present work, we generated and characterised ΔBcest deletion mutants of B. cinerea and constructed complemented strains. The ΔBcest deletion mutants exhibited reduced conidia germination and germ tube elongation. The functional activity of ΔBcest deletion mutants was illustrated by reduced necrotic colonisation of B. cinerea on strawberries and grapes fruits. Targeted deletion of Bcest also blocked several phenotypic defects in aspects of mycelial growth, conidiation and virulence. All phenotypic defects were restored by targeted gene complementation. The role of Bcest in pathogenicity was also supported by reverse transcriptase real-time quantitative PCR (qRT-PCR) results, which indicated that the melanin synthesis gene Bcpks13 and the virulence factor Bccdc14 were significantly downregulated in the early infection stage of the ΔBcest strain. Taken together, these results suggest that Bcest plays important roles in the regulation of various cellular processes in B. cinerea.
Composite fault diagnosis of traction motor of high-speed train based on support vector machine and sensor
Authors: Li Yanshu , Li Fang , Lu Chang , Fei Jiyou , Chang Baoxian 
Published: February 2023

Abstract
The body of high-speed train is the most closely related part with passengers in the process of train operation. Traction motor is not only the power source of high-speed train, it is also the basic unit form that can reflect the reliable and stable operation of high-speed trains. The running safety of the train can be effectively protected by diagnosing the traction fault of the train. Based on research data on the development process of high-speed rail,this paper introduces the importance and pertinence of this research. Based on the study of separable linear SVM and nonlinear SVM, the composite fault diagnosis for traction motor using SVM technology is realized.After discussing the actual faults of current sensor and position sensor and their causes, a dynamic model based on traction motor is established and its parameters are simulated. Finally, a diagnostic observer is designed based on an example to determine the sensitivity of the composite fault to the high-speed rail traction motor, and experiments are designed to verify the detection results. Finally, this paper concludes by describing,and then points out some deficiencies and shortcomings of the research, which guides the direction and lays the data foundation for the subsequent research work. This paper studies the load fault of traction motor through a comprehensive analysis of SVM and sensor technology, which improves the effectiveness and practical efficiency of fault detection.
Smart Presentation System Using Hand Gestures
Authors: Pustode Bhairavi , Pawar Vedant , Pawar Varun , Pawar Tejas , Pokale Samiksha 
Published: February 2023

Abstract
Presentations are crucial in many aspects of life. If you're a student, an employee, or if you are an entrepreneur, a businessperson, or an employee of a company, you must have presented presentations at eventually in your life. Sometimes, presentations lose vitality because you must use the keyboard or a specialized gadget to adjust and manage the slides. Our objective is to allow people to control the slideshow using hand gestures. The usage of gestures in human-computer interaction has drastically risen in recent years. The system has tried to govern numerous PowerPoint functionalities using hand movements. In this system, machine learning has been applied to recognize motions with tiny differences and map them using multiple libraries in Python. The rising hurdles to creating the optimal presentation are due to several aspects, including the slides, the keys to changing the slides, and the audience's calmness. An intelligent presentation system employing hand gestures gives a simple method to update or control the slides. There are several pauses during presentations to operate the presentation using the keyboard. The system's purpose is to enable users to use hand gestures to control and explore the slideshow. The technique employs machine learning to identify various hand gestures for many tasks. A recognition technique offers an interface for human system communication.
Computational Humor Recognition: A Systematic Literature Review
Authors: Kalloniatis Antony , Adamidis Panagiotis 
Published: February 2023

Abstract

Computational humor recognition is considered to be one of the hardest tasks in natural language processing (NLP) since humor is such a particularly complex emotion. There are very few recent studies that offer analysis of certain aspects of computational humor. However, there has been no attempt to study the empirical evidence on computational humor recognition in a systematic way. The aim of this research is to examine computational humor detection from four aspects: datasets, features and algorithms. Therefore, a Systematic Literature Review (SLR) is carried out to present in details the computational techniques for humor identification under these aspects. After posing some research questions, a total of 106 primary papers were recognized as relevant to the objectives of these questions and further detailed analysis was conducted. The study revealed that there is a great number of publicly available annotated humor datasets with many different types of humor instances. Twenty one (21) humor features have been carefully studied and research evidence of their use in humor computational detection is presented. Additionally, a classification of the humor detection approaches was performed and the results are submitted. Finally, the challenges of applying these techniques to humor recognition as well as promising future research directions are discussed.
Isolation, Characterization and Safety Assessment of Probiotic Lactic Acid Bacteria from Metata Ayib (Traditional Spiced Cottage Cheese)
Authors: Adugna Mulugojjam , Andualem Berhanu 
Published: February 2023

Abstract
(1) Background: Consumption of fermented foods and beverages has health benefits; fermented milk products in particular are thought to contain probiotics. The purpose of this study was to characterize probiotic property of lactic acid bacteria isolates from metata ayib.
(2) Methods: LAB isolates from metata ayib were isolated and purified for characterization of its probiotic activity.
(3) Results: A total of 80 LAB isolates were isolated and purified. The majority of isolates, 67 (83.75%), had bacilli shapes, and 59 (73.75%) were homofermentative. All 80 (100%) isolates were tolerated at pH 3.0 treated for three hours; but only 6 (7.5%) isolates were survived at pH 2.0. After 0.3 and 0.5% bile salt treatment for 24 hours, all 6 (7.5%) LAB isolates survived above 92.09±0.18 and 83.39±0.21%, respectively. All the 6 isolates were identified as Lactobacillus species; and all were hydrophobicity positive. K. pneumoniae was resistant but S. aureus was sensitive to all of six identified LAB isolates cell free supernatant. All 6 isolates were ciprofloxacin, chloramphenicol, cotrimoxazole and erythromycin-sensitive. Vancomycin resistance was present in four isolates. All these six Lactobacilli species were non-hemolytic, non-biogenic amine producing, and gelatin hydrolysis negative.
(4) Conclusion: Thus, Lactobacilli species isolated from metata ayib may be used as the suitable candidates of probiotics, and bio-therapeutics agents against bacterial infection to humans.
The reporting of study limitations and hedging in articles with and without causal diagrams
Authors: Cortes Taísa Rodrigues , Silveira Ismael Henrique , Schlussel Michael Maia , Werneck Guilherme Loureiro , Struchiner Claudio José 
Published: February 2023

Abstract

Causal directed acyclic graphs (DAG) are known to constitute a useful tool to improve the methodological and reporting quality of observational studies. At the same time, there are concerns that their (mis)use may lead to overconfident inferences. In this study, we investigate the reporting of study bias and limitations, and the use of hedging in articles with and without causal DAG. We performed a keyword search in two electronic databases (Medline and Web of Science) and one full-text repository (PubMed Central). The search strategy aimed to identify biomedical studies with an analytical observational design, that reported use of causal DAG. We selected a random sample of the articles that presented a graphic structure. We pair-matched individually 130 DAG with 130-Non-DAG papers on journal and issue. The number of research limitations acknowledged by the authors and of hedging terms per 100 words were analyzed using multiple linear regression models. From 2000 to 2020, we identified 2256 publications reporting the use of causal DAG, of which 1131 (50%) contained the actual graph structure. The number of study limitations acknowledged by the authors and the frequency of hedging were found to be similar in both samples. However, quantitative evaluations of study limitations were more frequently reported in studies with DAG (51 % vs. 25 %), while bias modeling techniques were uncommon in both groups (18% in DAG and 6% in non-DAG). In order to contextualize our findings, we used causal diagrams to discuss potential mechanisms for the communication of causal assumptions and related uncertainties in observational studies.