bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of mental disorders, psychosocial distress, and perceived need for psychosocial support in cancer patients and their relatives stratified by biopsychosocial factors: rationale, study design, and methods of a prospective multi-center observational cohort study (LUPE study)
Authors: Mehnert-Theuerkauf Anja , Hufeld Julia Marie , Esser Peter , Goerling Ute , Hermann Myriel , Zimmermann Tanja , Reuter Hannah , Ernst Jochen 
Published: April 2023

BackgroundDespite remarkable progress, cancer remains a life-threatening disease for millions of people worldwide, also resulting in significant psychosocial limitations. High-quality, comprehensive cancer care requires patient and family involvement and the provision of needs-based, targeted psychosocial services. Although progress has been made in understanding the occurrence of mental comorbidity and psychosocial distress in cancer patients, comparatively little is known about the course of psychological comorbidity and psychosocial distress in early survivorship among patients and their families. We therefore aim to estimate the prevalence of mental disorders according to the DSM-5, psychosocial distress, perceived needs for psychosocial support and utilization of psychosocial support offers in newly diagnosed cancer patients and their relatives, taking into account potential contributing biopsychosocial factors for the occurrence of psychological comorbidity.Methods/designThis study follows a prospective multi-center observational cohort design across four measurement time points: within 2 months after cancer diagnosis (t1), and in the follow-up period at 6 months (t2), at 12 months (t3), and at 18 months (t4) after t1. Patients older than 18 years who have a confirmed initial diagnosis of a malignant solid tumor and are scheduled for cancer treatment at one of the participating cancer centers are eligible for study participation. Relatives of eligible patients are also eligible for study participation if they are older than 18 years. Patients are interviewed using the Structured Clinical Interview for DSM-5 Disorders (SCID-5-CV). In addition, patients and relatives receive a set of validated questionnaires at each measurement time point, covering comorbid conditions and functional performance, perceived psychological distress and quality of life, partnership aspects and social relationships, supportive care needs and use of psychosocial support services, health literacy, and health behavior and meaning in life.DiscussionThis prospective multi-center observational cohort study has a major focus on increasing quality of care and quality of life in cancer survivors through providing rigorous longitudinal data for the development and implementation of target group-specific psychosocial support services.Trial registrationNCT04620564, date of registration 9/11/2020; DKG OnkoZert: Registrier-No.: ST-U134, date of registration 5/11/2021.
Comparison of different approaches to manage multi-site magnetic resonance spectroscopy clinical data analysis
Authors: La Parker L. , Bell Tiffany K. , Craig William , Doan Quynh , Beauchamp Miriam H. , Zemek Roger , Yeates Keith Owen , Harris Ashley D. 
Published: April 2023

IntroductionThe effects caused by differences in data acquisition can be substantial and may impact data interpretation in multi-site/scanner studies using magnetic resonance spectroscopy (MRS). Given the increasing use of multi-site studies, a better understanding of how to account for different scanners is needed. Using data from a concussion population, we compare ComBat harmonization with different statistical methods in controlling for site, vendor, and scanner as covariates to determine how to best control for multi-site data.MethodsThe data for the current study included 545 MRS datasets to measure tNAA, tCr, tCho, Glx, and mI to study the pediatric concussion acquired across five sites, six scanners, and two different MRI vendors. For each metabolite, the site and vendor were accounted for in seven different models of general linear models (GLM) or mixed-effects models while testing for group differences between the concussion and orthopedic injury. Models 1 and 2 controlled for vendor and site. Models 3 and 4 controlled for scanner. Models 5 and 6 controlled for site applied to data harmonized by vendor using ComBat. Model 7 controlled for scanner applied to data harmonized by scanner using ComBat. All the models controlled for age and sex as covariates.ResultsModels 1 and 2, controlling for site and vendor, showed no significant group effect in any metabolites, but the vendor and site were significant factors in the GLM. Model 3, which included a scanner, showed a significant group effect for tNAA and tCho, and the scanner was a significant factor. Model 4, controlling for the scanner, did not show a group effect in the mixed model. The data harmonized by the vendor using ComBat (Models 5 and 6) had no significant group effect in both the GLM and mixed models. Lastly, the data harmonized by the scanner using ComBat (Model 7) showed no significant group effect. The individual site data suggest there were no group differences.ConclusionUsing data from a large clinical concussion population, different analysis techniques to control for site, vendor, and scanner in MRS data yielded different results. The findings support the use of ComBat harmonization for clinical MRS data, as it removes the site and vendor effects.
Long-term quality of life and functional outcomes in adults surgically treated for intramedullary spinal cord tumor
Authors: Tufo Tommaso , Grande Eleonora , Bevacqua Giuseppina , Di Muccio Ines , Cioni Beatrice , Meglio Mario , Ciavarro Marco 
Published: April 2023

IntroductionIntramedullary spinal cord tumors (IMSCTs) are rare but clinically significant entities that may cause severe neurological decline with progressive pain and motor or sensory deterioration. Beyond the beneficial effects of surgical treatment and the long-term progression-free survival, neurological deficits may still persist after surgery, and information about the long-term patients' health-related quality of life (QoL) is still lacking. In this study, we investigate the patients' health perception 15 years after the surgery in an overall patients' wellbeing framework.MethodsPatients surgically treated for IMSCT over a period from 1996 to 2011 were selected. After a mean of 15 years from the surgery, patient's self-administered questionnaire on disability, pain, sleep quality, and QoL was collected and neurological postoperative evaluation at the chronic stage was reexamined.ResultsNeurological deficits are reported in half of the patients in the postoperative chronic phase. After 15 years of surgery, half of the patients still report mild or severe disability grades associated with significantly higher pain and poor sleep and QoL. In accordance, the neurological condition measured at the chronic stage is significantly related not only to disease-specific symptoms (i.e., pain) but even to sleep quality complaints and poor QoL, measured at 15 years follow-up.ConclusionsHealth-related QoL is an important secondary outcome in patients. Although the progression-free survival, worse postoperative neurological conditions could predict long-term sequelae reflecting patients' poor health perception. It suggests the importance of preserving patients' functional status and globally evaluating patients' wellbeing to handle disease-specific symptoms but even more general aspects of QoL.
Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction
Authors: Winter Anja L. , Henecke Sofie , Lundström Johan N. , Thunell Evelina 
Published: April 2023

IntroductionOlfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection. The associated daily life problems can cause a decreased quality of life.MethodsHere, we assessed the association between perceived quality of life and both qualitative and quantitative olfactory function (distorted and weakened sense of smell, respectively) in 58 individuals who had undergone confirmed SARS-CoV-2 infection and who complained about olfactory dysfunction.ResultsParticipants with large quantitative olfactory dysfunction experienced a greater reduction in their quality of life. Moreover, our participants had a high prevalence of qualitative olfactory dysfunction (81%) with a significant correlation between qualitative olfactory dysfunction and daily life impairment. Strong drivers of low quality of life assessments were lack of enjoyment of food as well as worries related to coping with long-term dysfunctions.DiscussionThese results stress the clinical importance of assessing qualitative olfactory dysfunction and the need to develop relevant interventions. Given the poor self-rated quality of life observed, healthcare systems should consider developing support structures, dietary advice, and guidelines adapted to individuals experiencing qualitative olfactory dysfunction.
Metabolic biomarkers of risperidone-induced weight gain in drug-naïve patients with schizophrenia
Authors: Qiu Yuying , Dong Yeqing , Sun Wei , Li Gang , Li Mei Juan , Zhao Yongping , Jiang Changyong , Li Jie 
Published: April 2023

BackgroundRisperidone is a commonly prescribed antipsychotic drug with a potential side effect of weight gain. However, the pathophysiological mechanism is still poorly understood. Here, we sought to identify potential biomarkers of risperidone-induced weight gain by using a targeted metabolomics approach.MethodsWe enrolled 30 subjects who received risperidone monotherapy for 8  weeks from a prospective longitudinal cohort study for drug-naïve schizophrenia patients. Plasma metabolites were measured by targeted metabolomics Biocrates MxP® Quant 500 Kit at baseline and 8-week follow-up.ResultsAfter 8  weeks of risperidone treatment, the levels of 48 differential metabolites were upregulated, including lysophosphatidylcholines (2), phosphatidylcholines (PC) (8), cholesteryl esters (CE) (3), and triglycerides (35), while 6 differential metabolites namely PC aa C38:6, methionine (Met), α-aminobutyric acid (AABA), TrpBetaine, CE (22:6), and Taurocholic acid (TCA) were downregulated. Interestingly, the reduction of PC aa C38:6, AABA and CE (22:6) was linearly related with increased BMI. Further multiple regression analysis showed that the changes of PC aa C38:6 and AABA were independent contributors of increased BMI. In addition, baseline levels of PC aa C36:5, CE (20:5) and AABA had positive relationships with the change of BMI.ConclusionOur findings indicate phosphatidylcholines and amino acids may serve as biomarkers for risperidone-induced weight gain.
Effects of Drought and Flooding on Phytohormones and Abscisic Acid Gene Expression in Kiwifruit
Authors: Wurms Kirstin V. , Reglinski Tony , Buissink Poppy , Ah Chee Annette , Fehlmann Christina , McDonald Stella , Cooney Janine , Jensen Dwayne , Hedderley Duncan , McKenzie Catherine , Rikkerink Erik H. A. 
Published: April 2023

Environmental extremes, such as drought and flooding, are becoming more common with global warming, resulting in significant crop losses. Understanding the mechanisms underlying the plant water stress response, regulated by the abscisic acid (ABA) pathway, is crucial to building resilience to climate change. Potted kiwifruit plants (two cultivars) were exposed to contrasting watering regimes (water logging and no water). Root and leaf tissues were sampled during the experiments to measure phytohormone levels and expression of ABA pathway genes. ABA increased significantly under drought conditions compared with the control and waterlogged plants. ABA-related gene responses were significantly greater in roots than leaves. ABA responsive genes, DREB2 and WRKY40, showed the greatest upregulation in roots with flooding, and the ABA biosynthesis gene, NCED3, with drought. Two ABA-catabolic genes, CYP707A i and ii were able to differentiate the water stress responses, with upregulation in flooding and downregulation in drought. This study has identified molecular markers and shown that water stress extremes induced strong phytohormone/ABA gene responses in the roots, which are the key site of water stress perception, supporting the theory kiwifruit plants regulate ABA to combat water stress.
Characterization and Control of Dendrobium officinale Bud Blight Disease
Authors: Zhang Jinzhao , Sha Haodong , Chen Weiliang , Mao Bizeng 
Published: April 2023

Dendrobium officinale is an important traditional Chinese medicine (TCM). A disease causing bud blight in D. officinale appeared in 2021 in Yueqing city, Zhejiang Province, China. In this paper, 127 isolates were obtained from 61 plants. The isolates were grouped into 13 groups based on collected areas and morphological observations. Four loci (ITS, LSU, tub2 and rpb2) of 13 representative isolates were sequenced and the isolates were identified by constructing phylogenetic trees with the multi-locus sequence analysis (MLSA) method. We found the disease to be associated with three strains: Ectophoma multirostrata, Alternaria arborescens and Stagonosporopsis pogostemonis, with isolates frequencies of 71.6%, 21.3% and 7.1%, respectively. All three strains are pathogenic to D. officinale. A. arborescens and S. pogostemonis isolated from D. officinale were reported for the first time. Iprodione (50%), 33.5% oxine-copper and Meitian (containing 75 g/L pydiflumetofen and 125 g/L difenoconazole) were chosen to control the dominant pathogen E. multirostrata, with an EC50 value of 2.10, 1.78 and 0.09 mg/L, respectively. All three fungicides exhibited an effective inhibition of activities to the growth of the dominant pathogen E. multirostrata on potato dextrose agar (PDA) plates, with Meitian showing the strongest inhibitory effect. We further found that Meitian can effectively control D. officinale bud blight disease in pot trial.
Introduction. Musique, histoire et géographie
Authors: Goeury Julien , His Isabelle , Poton Didier 
Published: April 2023

Le numéro 33 de la revue Albineana réunit les actes du colloque intitulé
Musiques et société dans les provinces de l’Ouest au cours des guerres de religion, qui s’est tenu les 12 et 13 février 2020 à l’Abbaye-aux-Dame de Saintes, en Charente-Maritime.
A produção de um podcast como projeto de extensão universitária em uma faculdade de medicina de Belo Horizonte
Authors: Lara Luísa Lopes Prata , Moreira Letícia Alves , Ramos Marina Todeschi , Campos Victor Grigorio , Pereira Ricardo Rodrigues , Staico Bruna Machado , E Silva Marina Antonini , De Castro Eduarda Andrade Monteiro , Miranda Davi Mesquita , Camillozzi Abner Felipe Tomaz , Rodrigues Flávia Guimarães 
Published: April 2023

Introdução: A extensão universitária possibilita que o conhecimento sistemático desenvolvido no ambiente da universidade ultrapasse seus muros e seja apresentado à comunidade. Diante disso, as formas digitais de comunicação se tornaram uma fonte ágil e eficiente para a disseminação de conteúdos científicos. Em especial, os podcasts, que transformam os usuários em produtores de conteúdos e favorecem abordagens regionais e de representação social. Objetivo: Descrever a experiência de um projeto de extensão universitária no desenvolvimento de episódios de podcasts sobre educação em saúde. Método: Trata-se de um estudo descritivo, baseado em relato de experiência. O projeto de extensão Podcast: “Saúde: Direto ao assunto”, que mais tarde foi denominado Podcast: Pato Talk, foi realizado entre agosto de 2022 e fevereiro de 2023. Os roteiros dos episódios foram elaborados pelos discentes envolvidos no projeto de extensão, a revisão técnica realizada pelo docente orientador e as gravações e edição dos episódios realizadas no Hub Tecnológico da instituição de ensino. Resultados: No estudo, foram elaboradas duas temporadas do Pato Talk, com um total de quatro episódios, com a proposta de divulgar informações científicas sobre temas da saúde de acordo com as cores dos meses do ano (Outubro Rosa e Novembro Azul), através de entrevistas com especialistas, que formaram o acervo de podcasts da instituição de ensino. Os episódios do podcast, tiveram uma duração aproximada entre 10 e 15 minutos. Conclusão: Com a construção de podcasts, é possível divulgar conhecimento na área da saúde no sentido de desmistificar notícias falsas e promover educação em saúde de forma inclusiva.
Frequency of Gallstones in Fatty Liver disease in a Tertiary Care of Suburban Islamabad
Authors: Iftikhar Ahmed  , Arslan Zahid  , Nauman Mustafa  , Iram Iqbal  , Asma Bibi  , Fauzia Rashid  , Shabir Rana  , Tariq Nawaz  
Published: April 2023

Background: Gallstone disease and Non-Alcoholic Fatty Liver Disease (NAFLD) share common etiological pathways. The objective of this study was to determine the frequency of Gallstones and Non-Alcoholic Fatty Liver disease (NAFLD) in patients undergoing abdominal ultrasounds in our hospital and to compare the frequency of Gallstone disease in patients with NAFLD and without NAFLD.
Methodology: This cross-sectional study was carried out at HBS General Hospital, Islamabad from January 2020 till December 2020. Patients undergoing routine ultrasounds in the out-patient department of the hospital were included in the study. Patients having Emergency Ultrasounds, history of Alcohol intake, history of chronic liver disease and pregnant patients were excluded from the study. Data was analysed using Microsoft Excel 2016 and IBM SPSS 22.
Results: A total of 689 patients were included with a 3:1 Female to Male ratio. Mean Age was 40.65± 15.610 years. The prevalence of Gallstone disease was found to be 20.9% while that of NAFLD 27.6%. A higher percentage of patients with NAFLD had Gallstones as compared to those who did not have NAFLD (24.2% vs 19.6% respectively) however for overall data, statistical significance was not reached. A statistically significant greater number of young patients with NAFLD had Gallstones as compared to those who did not have NAFLD (50% vs 6%, p<0.001). Mean age was greater in patients who had NAFLD as well as those having Gallstones.
Conclusion: The frequency of Gallstones was greater in patients with NAFLD as compared to those without NAFLD.
Keywords: Cholelithiasis, Fatty Liver Disease, Gallstones, Non-Alcoholic, Ultrasonogram
Understanding the onset of EUV resist chemical stochastics
Authors: Denbeaux Greg , Azhari Nabihah , Ai Ruiwen , Kahl Benjamin , Painter Micah , Adamson Zachary , Aldrin Ashley , Dilina Eshan , Choudhary Ankit , Brainard Robert L. 
Published: April 2023

Abstract
The ability of chemically amplified resists to transfer an aerial image at increasingly smaller dimensions is critical to EUV lithography success at increasingly smaller process nodes [Bisschop and Hendrickx, Extreme Ultraviolet (EUV) Lithography X (SPIE) 10957 37 (2019)]. Stochastic inhomogeneities in resist exposure and patterning have been studied, which include photon shot noise and resist surface roughness. However, previous work has indicated that inhomogeneities and defectivity are present in multicomponent resists beyond those predicted by random statistics [Jablonski et al. (Santa Clara, CA) p. 302 (2004); Woodward et al. Advances in Resist Materials and Processing Technology XXIV (SPIE) 6519 416 (2007); Fedynyshyn et al. Advances in Resist Technology and Processing XXIII (SPIE) 6153 387 (2006); Fedynyshyn et al. J. Vac. Sci. Technol. B, 24, 3031 (2006); Kohyama et al. Advances in Patterning Materials and Processes XXXVI (SPIE) 10960 218 (2019)]. This is thought to be due to self-segregation of components in the multi-component chemically amplified resist. The results in this paper show that the most critical part of the resist chemical segregation occurs during the spin coating process after a significant amount of the solvent has evaporated, but while there is still enough solvent to enable molecular mobility within the resist.
Efficiency of using tank mixtures of fungicides for the control of phytopathogens in potato agrocenoses
Authors: Taktaiev B. , Podberezko I. , Furdyha M. , Oliinyk T. , Sihariova D. 
Published: April 2023

Goal. To evaluate the level of effectiveness of phytopathogen control elements in agrocenoses of potatoes for different combinations of pesticides with biologically active substances, methods of application and the reaction of Aria potatoes to them.
Methods. Field — for monitoring the main diseases of potatoes in field experiments, recording the harvest, determining the effectiveness of combinations of fungicides with plant growth regulators and microfertilizers; laboratory — for recording damage to tubers by diseases. Research was conducted in accordance with generally accepted methods.
Results. In 2019—2021, the Laboratory of Plant Immunity and Protection of the Institute of Potato Breeding of the National Academy of Sciences conducted research on the improvement of elements of phytopathogen control technology in potato agrocenoses under various schemes of using tank mixtures of fungicides, growth regulating substances (RRS) and microfertilizers. The research used the Aria variety selected by the institute. The lowest level of development of Alternaria was in the version where tuber treatment was carried out (fungicide impregnant + microfertilizer + PPR) and two plant treatments (Kurzat R + microfertilizer + PPR). The development of the disease was 14.7% for the spread of 66.6%, and the technical efficiency of the protection elements was 68.8%. To effectively control the development of common scab, rhizoctoniosis and fusarium dry rot, it is advisable to treat tubers with a tank mixture of impurity-fungicide + PPR + microfertilizer and to treat plants with a mixture of Kurzat P + PPR + microfertilizer, which significantly reduces the level of tuber disease control and limits their spread compared to and chemical standards. The yield of potatoes in the variants was higher than in the control (25.4 t/ha) — 29.8—36.8 t/ha. The level of the preserved harvest compared to the control was in the range of 4.4—11.4 t/ha or 17.3—44.9%. The highest level of yield (36.8 t/ha) was in the variant: treatment of tubers — impregnation-fungicide + micro-fertilizer + PPR and two plant treatments — Cuproxate + micro-fertilizer + PPR. This indicator is 11.4 t/ha (44.9%) higher than the control and 4.7 t/ha (14.6%) higher than the standard.
Conclusions. The use of tank mixtures of fungicides with a growth regulator and microfertilizer significantly reduces the level of potato diseases and increases the yield. It was established that the use of a mixture of impurity-fungicide + PPR + microfertilizer for treating potato tubers and Kurzat P + microfertilizer + PPR for treating plants significantly reduces the level of common scab, rhizoctoniosis and fusarium dry rot and limits their spread, compared to control and chemical standards.