bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Education Quality Improvement in Junior High School
Authors: Adji Abdul , Hidayatulloh Hidayatulloh 
Published: December 2022

Penelitian ini bertujuan untuk mendapatkan gambaran tentang upaya yang dilakukan SMP Al-Islamiyah Putat Tanggulangin Kabupaten Sidoarjo dalam menciptakan kemampuan untuk Survive di tengah gelombang kebijakan Pemerintah terkait bidang pendidikan sebagai bukti nyata dari daya tahan (durability) suatu lembaga pendidikan, di sisi lain semakin banyaknya kompetitif lembaga pendidikan baru dengan tawaran berbagai program unggulan. Menciptakan lembaga sekolah swasta yang sumberdayanya diadakan dengan lebih besar pada swadaya dan dana menuju sekolah yang bermutu, pilihan alternatif, atau bahkan rujukan tidaklah mudah. Penelitian ini adalah penelitian kualitatif, dengan menggunakan pendekatan fenomenologi, adapun cara memperoleh data dilakukan dengan pengamatan (observasi), wawancara (interview), dan dokmentas, setelah data terkumpul dilakukan analisis sehingga menghasilkan simpulan sekolah SMP Al-Islamiyah ini mampu bersaing dengan sekolah lain baik sekolah negeri maupun swasta di sekitarnya. Sekolah ini secara implisit sudah menerapkan MPMBS dan upaya penjaminan mutu internal dan eksternal, adapun yang mendukung survive-nya sekolah ini pada beberapa hal berikut; jumlah siswa stabil atau bahkan bertambah setiap tahunnya, sarana prasarana cukup terpenuhi, Kepercayaan masyarakat masih cukup tinggi, sekolah memiliki corak Islami meskipun sekolah umum, tidak berafiliasi dengan organisasi masyarakat tertentu, kualifikasi pendidikan guru-gurunya memadai berpotensi dapat mengajar dengan efektif, perpustakaan berjalan dengan baik, moralitas peserta didik baik, biayanya standar (terjangkau).
Opportunities of E-Learning in Online Testing of English Language Proficiency
Authors: Shuxratovna Khamrayeva Shaxlo 
Published: December 2022

Currently due to the widespread pandemic, the problem of e-learning organization has become crucially important, thus the role of arranging online testing of students of higher educational institutions has significantly enhanced. In this regard, the article discusses the essence of the online testing, its advantages and disadvantages and the ways to organize online testing during e-learning process. In addition, the article provides scientific recommendations aimed at improving the use of online testing in the educational process.
Academic Procrastination for Students of the Faculty of Psychology and Educational Sciences (FPIP) at the University
Authors: Izzati Roudhotul , Nastiti Dwi 
Published: December 2022

The research motivated by phenomenon of students experiencing academic procrastination. This study aims to describe the picture of academicprocrastination that occurs in the Faculty of Psyichology and Education, University of Muhammadiyah Sidoarjo (UMSIDA). This type of research uses a quantitative approach with a descriptive type of research. The research population is the students of the Faculty of Psichology and educational Sciences for the 2019-2020 academic year, totaling 2.000 students. The sample of this study was 249 students using the propotional random sampling technique. The research data collection technique used a psychological scale with a Likert scale type, namely the academic procrastination scale. The data analysis technique used descriptive statistics with the product moment correlation technique using the SPSS 19.0 for windows program. The results showed that overall all students of the Faculty of Psychology and educational Sciences (FPIP) at the University of Muhammadiyah Sidoarjo did academic procrastination, in this study it was 75,5%.
TGF-β-induced MIR99AHG synergizes with PTBP1 to trigger a splicing switch of SMARCA1 that promotes invadopodia formation for metastasis in colorectal cancer
Authors: Li Danxiu , Wang Xin , Miao Hui , Liu Hao , Pang Maogui , Guo Hao , Ge Minghui , Glass Sarah E. , Emmrich Stephan , Ji Songtao , Ye Xiaoni , Wang Jing , Liu Qi , Kim Taewan , Klusmann Jan-Henning , Li Cunxi , Nie Yongzhan , Wu Kaichun , Fan Daiming , Song Xu , Wang Xing , Li Ling , Lu Yuanyuan , Zhao Xiaodi 
Published: December 2022

Abstract
Alternative splicing (AS) of pre-mRNAs is an essential process that regulates gene expression and functional diversity, yet the underlying regulatory mechanisms that control this process during cancer metastasis are not clear. Here, we uncovered that a long non-coding RNA (lncRNA), MIR99AHG, mediates regulation of AS to alter chromatin remodeler function and promote invadopodia formation in colorectal cancer (CRC). We found that MIR99AHG is highly expressed in metastatic CRC cells and patient tissue samples. In vitro and in vivo assays showed that MIR99AHG potently drove CRC cell motility, invasion, and metastasis. MIR99AHG bound to and stabilized the RNA splicing factor PTBP1, which cooperatively increased cassette exon inclusion of the chromatin remodeling gene SMARCA1. Mechanistically, MIR99AHG acted as an address label for PTBP1 to fine-tune its binding pattern on SMARCA1 pre-mRNA, thereby controlling the skipping-to-inclusion splicing switch of SMARCA1 and favouring the production of a long isoform (SMARCA1-L). Canonical SMARCA1 was found to suppress cell migration and invasiveness by inhibiting invadopodia formation, but SMARCA1-L was functionally inert. Clinicaldata revealed that MIR99AHG was positively correlated with PTBP1 and SMARCA1-L in human CRC specimens and predicted patient outcome. Furthermore, we showed that the crosstalk with cancer-associated fibroblasts triggers TGF-β/SAMD signalling in CRC cells and activates MIR99AHG expression. Our findings establish a novel mechanism for a lncRNA that interacts with PTBP1 to regulate AS process, providing a potential therapeutic target and predictive biomarker of CRC.
Molecular dynamics and minigene assay of a splicing COL4A5 gene variant causing Alport syndrome
Authors: Liang Lei , Wu Haotian , Cai Zeyu , Zhao Jianrong 
Published: December 2022

Abstract
Alport syndrome (AS; OMIM#308940) is a progressive hereditary kidney disease characterized by hearing loss and ocular abnormalities. According to the mode of inheritance, AS has three subtypes: X-linked (XL; OMIM#301050), autosomal recessive (AR; OMIM#203780), and autosomal dominant (AD; OMIM#104200). XLAS is caused by a pathogenic variant in COL4A5 (OMIM*303630) gene encoding type IV collagen (Col-IV) α5 chain, while ADAS and ARAS are consequences of a variant in COL4A3 (OMIM*120070) and COL4A4 (OMIM*120131) genes that encode Col-IV α3 and α4 chains, respectively. Usually, diagnosis of AS requires hereditary or pathological examinations. Splicing variants are hard to be determined as pathogenic or non-pathogenic based on the results of gene sequencing. This study focused on a splicing variant in COL4A5 gene, termed NM_000495.5: c.4298-20T > A, and to analyzed its authenticity and damaged α5 chain. In vitro minigene splicing assay was applied to investigate the effect of splicing variant, c.4298-20T > A, on COL4A5 mRNA synthesis. Molecular dynamics method was used to predict the capability of the responsible α5(IV) to form a triple helix. The intron 46 of COL4A5 mRNA retained 18 bp, resulting in insertion of 6 amino acids behind the amino acid at position 1433 of α5(IV). The predicted protein effect of this variant: p. (Pro1432_Gly1433insAspTyrPheValGluIle). As a consequence, the stability of α5(IV) secondary structure was impaired, probably leading to the unusual configuration of α345(IV). Normally, splicing variant in COL4A5 gene can lead to phenotypes of XLAS, and the effect is associated with the extent of splicing. The patient reported here carried a c.4298-20T > A splicing variant in COL4A5 gene, and AS was highly suspected based on the pathology results. However, the patient did not manifest any ocular or ear abnormalities. We therefore present the c.4298-20T > A splicing variant in COL4A5 gene as likely-pathogenic splicing variant that leads to XLAS with mild phenotypes.
Evaluation Of The Arterial Folding Point During Flexion Of The Hip: about 37 dynamic angiographies
Authors: MARTIN Théodore , MATHY Marie , FEUGIER Patrick , VISTE Anthony 
Published: December 2022

Abstract
Purpose
The aim of the study was to determine the location of the folding point of the arterial ilio-femoral axis and its angulation.
Materials and methods
Forty-five dynamic arteriographies were analyzed and 37 were included in the current study. Different lengths were measured, based on specific anatomical landmarks: the departure of the external iliac artery, the inguinal ligament and the bifurcation of the femoral artery. These lengths were measured in extension and during flexion of the hip in order to determine the folding point of the artery.
Results
In extension, some physiological angulations of the external iliac artery were measured.
During flexion of the hip joint, the distance from the folding point to the bifurcation of the common iliac artery was respectively 82 +/- 21 mm (range 48-116) on the right and 95 +/- 20 mm (range 59-132) on the left side. The distance from the folding point to the inguinal ligament was respectively 38 +/- 40 mm (range 12-138) on the right and 26 +/- 23 mm (range 8-136) on the left side. The distance from the folding point to the bifurcation of the femoral artery was respectively 45 +/- 29 mm (range 15-107) on the right and 27 +/- 12 mm (range 10-66) on the left side. During flexion, the angulation of the folding point of the ilio-femoral axis was 114 +/- 18 ° (range 81-136°).
Conclusions
The folding point was located cranially to the inguinal ligament and below the departure of the external iliac artery.
Factors related to ownership of health insurance cover in Navakholo, Kakamega County, Kenya: sub-county level results based on community household register
Authors: Ambalu Rachel , Rashid Sadiq , Atwa Saul , Otira Mariam , Ndolo Lucia , Ojakaa David 
Published: December 2022

Abstract
Background: In concert with international commitments, the Government of Kenya identified universal health coverage (UHC) as one of its four priority agenda to enable its populations have access to health care without financial duress. Nevertheless, only about 19.5% of the Kenyan population is enrolled in any insurance health cover. Since 2016, Amref Health Africa and PharmAccess Foundation have been implementing the innovative partnership on universal and sustainable healthcare (iPUSH) programme in Navakholo sub-county of Kakamega County. The objective of this study is to examine ownership of health insurance cover among women of reproductive age (WRA) in Navakholo sub-county, Kakamega County.
Methods: We analysed data captured during household registration conducted in February 2021. The dataset consisted of a total of 148,957 household members within 32,262 households, 310 villages, and 32 community health units. The data had been collected using mobile phones by trained community health volunteers (CHVs) and transmitted using the Amref electronic data management platform and reposited in a server. After much review of data quality, variables qualifying were analysed through descriptive and causal methods using STATA software.
Results: Insurance coverage in Navakholo sub-county stood at 11% among women aged 15-49 years who were either spouses of the head of household or heads of households themselves. This is much lower than the national aggregate reported from sample surveys, but higher than the 7% found in the same survey for the Western region where Navakholo is situated. Social determinant variables – age, perceived condition of the household, and wealth ranking – are highly significant in the relationship with ownership of health insurance cover while measures of reproductive health and health vulnerability are not.
Conclusions: In Navakholo sub-county of western Kenya, health insurance coverage is lower than the national aggregate estimated from sample surveys. Age, perception of household condition, and wealth ranking are very significantly related to ownership of a health insurance cover. Frequent household registrations should be conducted to help monitor the trends and impact of health insurance campaigns. Training – upstream and downstream – on community household registration and data processing should be conducted to arrive at better quality data.
Atypical immunologic manifestations of COVID-19: A case report and a comprehensive review
Authors: Shah Vedant , Patel Harsh , Oza Jaykumar , Patel Palak , Radhakrishnan Haripriya , Arunachalam Janani , Bag Soumyadeep , Patra Tumpa , Shekar Saketh Palasamudram 
Published: December 2022

Abstract
Introduction: COVID-19 usually presents with classic signs and symptoms, but it can involve multiple systems in atypical cases. SARS-CoV-2 has a complex interaction with the host immune system leading to atypical manifestations.
Case Presentation: In our case, a 32-year-old male patient presented with fatigue, sores on hands and feet, headache, productive cough with blood-tinged mucus, conjunctival hyperemia, purpuric rash on hands and feet, and splinter hemorrhages of fingernails for two weeks. The patient’s SARS-CoV-2 antigen and PCR test were positive. Chest x-ray showed mixed density perihilar opacities in both lungs. Computed tomography of the chest showed extensive airspace opacities in both lungs, suggesting COVID-19 multifocal, multilobar pneumonitis. A renal biopsy indicated limited thrombotic microangiopathy and tubulointerstitial nephritis, for which he was started on steroids, and his renal functions gradually improved. He tested positive for C-ANCA during an immune workup. He was discharged with a steroid taper for nephritis. Once the taper reached less than 10 mg/day, he developed acute scleritis and a new pulmonary cavitary lesion of 6 centimeters. The biopsy via bronchoscopy revealed acute inflammatory cells with hemosiderin-laden macrophages. He was restarted on systemic steroids for scleritis after failing topical steroids, which incidentally also reduced the size of the cavitary lesion, indicating an immune component.
Conclusions: Our case demonstrates the involvement of kidneys and vasculitis of the skin, sclera, and lungs by COVID-19. The patient’s symptoms were not explained by any diseases other than COVID-19. Atypical cases of COVID-19 disease with multifocal systemic symptoms involving the skin, sclera, lungs, and kidneys should be high on differentials. Early recognition and intervention may decrease hospital stays and morbidity.
MeJA-mediated enhancement of salt-tolerance of Populus wutunensis by 5-aminolevulinic acid
Authors: Liu Huan , Sun Jingliang , Zou Jixiang , Li Baisheng , Jin Hua 
Published: December 2022

Abstract
Background
5-Aminolevulinic acid (ALA) is a natural and environmentally benign multifunctional plant growth regulator involved in the regulation of plant tolerance to various environmental stresses. This research aimed to explore the molecular mechanisms of salt tolerance in Populus wutunensis induced by exogenous ALA using physiological and transcriptomic analyses.
Results
Physiological results showed that 50mg·L− 1 ALA-treatment significantly reduced the malondialdehyde (MDA) content and the relative electrical conductivity (REC) and enhanced antioxidant activities of enzymes such as SOD, POD and CAT in salt-stressed P. wutunensis seedlings. Transcriptome analysis identified ALA-induced differentially expressed genes (DEGs) associating with increased salt-tolerance in P. wutunensis. GO and KEGG enrichment analyses showed that ALA activated the jasmonic acid signaling and significantly enhanced the protein processing in endoplasmic reticulum and the flavonoid biosynthesis pathways. Results of the hormone-quantification by LC-MS/MS-based assays showed that ALA could increase the accumulation of methyl jasmonate (MeJA) in salt-stressed P. wutunensis. Induced contents of soluble proteins and flavonoids by exogenous ALA in salt-treated seedlings were also correlated with the MeJA content.
Conclusions
5-aminolevulinic acid improved the protein-folding efficiency in the endoplasmic reticulum and the flavonoid-accumulation through the MeJA-activated jasmonic acid signaling, thereby increased salt-tolerance in P. wutunensis.
An increased risk of pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema: a meta-analysis
Authors: Ni Hangqi , Wei Yuying , Yang Liuqing , Wang Qing 
Published: December 2022

Abstract

Background and aim: Pulmonary hypertension (PH) is a common complication of combined pulmonary fibrosis and emphysema (CPFE). Whether the incidence of PH is increased in CPFE compared with pure pulmonary fibrosis or emphysema remains unclear. This meta-analysis aimed to evaluate the prevalence of PH in the CPFE population. Methods We searched the PubMed, Embase, Cochrane Library, and CNKI databases for relevant studies focusing on the incidence of PH in patients with CPFE and IPF or emphysema. Pooled odds ratios (ORs) and standard mean differences (SMD) with 95% confidence intervals (95% CIs) were used to evaluate the differences in the clinical characteristics and prevalence of PH between patients with CPFE, IPF, or emphysema. The survival impact of PH in patients with CPFE was assessed using hazard ratios (HRs). Results A total of 19 eligible studies were included in the meta-analysis, involving 977, 1153, and 504 patients with CPFE, IPF, and emphysema, respectively. Patients with CPFE had an increased PH risk with a higher frequency of pulmonary hypertension and higher estimated systolic pulmonary artery pressure (esPAP), compared with those with IPF (OR: 1.96; 95% CI: 1.36–2.83;P < 0.01; SMD: 0.79; 95% CI: 0.55–1.02;P < 0.01) or emphysema (OR: 2.09; 95% CI: 1.42–3.06;P < 0.01; SMD: 0.75; 95% CI: 0.55–0.95;P < 0.01). In addition, the patients with CPFE combined with PH had a poor prognosis than patients with CPFE without PH (HR: 6.16; 95% CI: 2.53–15.03;P < 0.01). Conclusions Our meta-analysis showed that patients with CPFE were associated with a significantly higher prevalence of PH compared with those with IPF or emphysema alone. The presence of PH was a poor predictor of mortality.
Unravelling the genetic diversity and population structure of Persian walnut in the Iranian Plateau
Authors: Shavvon Robabeh Shahi , Qi Hai-Ling , Mafakheri Mohammad , Fan Pen-Zheng , Wu Hong-Yu , Vahdati Fatemeh Bazdid , Al-Shmgani Hanady S. , Wang Yue-Hua , Liu Jie 
Published: December 2022

Abstract
Background: Common walnut (Juglans regia L.) has a long cultivation history, given its highly valuable wood and rich nutritious nuts. The Iranian Plateau has been considered one of the last glaciation refugia and a center of origin and domestication for the common walnut. However, a prerequisite to conserve or utilize the genetic resources of J. regia in the Plateau is a comprehensive evaluation of the genetic diversity that is conspicuously lacking. In this regard, we used 31 polymorphic simple sequence repeat (SSR) markers to delineate the genetic variation and population structure of 508 J. regia individuals among 27 populations from the Iranian Plateau.
Results: The SSR markers expressed a relatively high level of genetic diversity (HO= 0.438, and HE= 0.437). Genetic differentiation among the populations was moderate (FST= 0.124), and genetic variation within the populations (79%) significantly surpassed among populations (21%). The gene flow (Nm= 1.79) may have remarkably influenced the population genetic structure of J. regia, which can be attributed to anthropological activities and wind dispersal of pollen. The STRUCTURE analysis divided the 27 populations into two main clusters. A comparison of the neighbor-joining (NJ) and Principal coordinate analysis (PCoA) dendrograms and the Bayesian STRUCTURE analysis revealed the general agreement between the population subdivisions and the genetic relationships among the populations. However, a few geographically close populations dispersed into different clusters. Further, the low genetic diversity of the SMR and TKR populations necessitates urgent in situ conservation; additionally, we recommend the indispensable preservation of the RGR and AKR populations.
Conclusion: These results reflected consistent high geographical affinity of the accession across the Plateau. Our findings suggest that gene flow is a driving factor influencing the genetic structure of J. regia populations, whereas ecological and geological variables did not act as a strong barrier. Moreover, the data reported herein provide new insights into the population structure of J. regia germplasm, which will help conserve genetic resources for the future improving walnut breeding programs’ efficiency.
Postoperative Bone Graft Migration Into The Thecal Sac, And Shifting Down To The Lower Level After An Endoscopic Lumbar Interbody Fusion: A Case Report And Literature Review
Authors: Xie Yizhou , Zhou Qun , Wang Yongtao , Feng Chengzhi , Fan Xiaohong , Yu Yang 
Published: December 2022

Abstract
Background
Postoperative bone graft migration (PBGM) is a fairly rare spinal postoperative complication. Its occurrence after endoscopic surgery has rarely been reported in the literature so far. This is a case report of a 52-year-old male occurring PBGM into the thecal sac in the 8th days after an endoscopic lumbar interbody fusion (ELIF).
Case Presentation
A 52-year-old male patient, underwent a L4-5 ELIF, presented with an acute radiculopathy on right leg and urinary incontinence in the 8th postoperative day. An emergency lumbar Computed Tomography(CT scan) and Magnetic Resonance Imaging (MRI) demonstrated bone graft migration into the thecal sac at the L4-5 level, and shifting down to the lower level. The revision surgery was performed at once. Finally, the patient get well managed before discharge.
Conclusion
PBGM into thecal sac is a rare but horrible complication of ELIF. However, too much volume of bone graft and its posteriorly placement are more prone to developing this complication. An emergency revision surgery is indicated once occurs.
Cytokine profiles in adults with imported malaria: insights from the PALUREA cohort study
Authors: de ROQUETAILLADE Charles , LAOUENAN Cédric , MIRA Jean-Paul , ROY Carine , THUONG Marie , AZOULAY Elie , GRUSON Didier , JACOBS Frederic , CHOMMELOUX Juliette , RAFFI François , HOCQUELOUX Laurent , IMBERT Patrick , JEANTILS Vincent , DELASSUS Jean-Luc , MATHERON Sophie , FITTING Catherine , TIMSIT Jean-François , BRUNEEL Fabrice 
Published: December 2022

Abstract
Introduction. Given the increase in worldwide exchanges, imported malaria is a growing health concern in non-endemic countries. Most data regarding malaria pathophysiology arises from endemic areas, and little is known about cytokine profiles during imported malaria.
Methods. We presented here the cytokines results of the PALUREA cohort study, which was conducted in France between 2006 and 2010. Adult patients were dichotomized between severe malaria (SM) and uncomplicated malaria (UM), and two subgroups were further defined in the SM group: very severe malaria (VSM) and less severe malaria (LSM). On hospital admission, cytokine blood tests were performed in duplicate using Luminex technology for eight cytokines: Interleukin (IL)-1a, IL-1ß, IL-2, IL-4, IL-10, Tumor necrosis factor (TNF)-a, Interferon (IFN)γ and Macrophage migration inhibitory factor (MIF). For SM patients, repeated tests were made during the first 2 days following admission.
Results. 278 patients were included in the cytokine analysis: 134 with UM and 144 with SM. For IL-1a, IL-1b, IL-2, IL-4, IFNγ and TNF-a, more than 50% of patients had undetectable levels on hospital admission, when IL-10 and MIF were significantly higher in severe cases. IL-10 was significantly associated with parasitemia (R=0.32 [0.16 ; 0.46]; p = 0.0001). Patients with elevated IL-10 during the first days of ICU stay were more prone to develop subsequent secondary infections.
Conclusion. Among the 8 tested cytokines, only MIF and IL-10 were associated with disease severity among adult patients with imported plasmodium falciparummalaria. On admission, many patients had undetectable cytokine level, which suggests that assessment of circulating cytokines levels is not relevant in routine evaluation of malaria patients.