bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant and neo‐adjuvant immunotherapy in resectable non‐small cell lung cancer (NSCLC): Current status and perspectives
Authors: Xu Ziyi , Zou Zihua , Hao Xuezhi , Xing Puyuan , Li Junling 
Published: February 2023

AbstractSurgery followed by adjuvant chemotherapy is the standard of care for selected patients with early‐stage or locally advanced non‐small cell lung cancer (NSCLC). However, many of these patients still experience postoperative recurrence at 5 years. At present, peri‐operative treatment methods are emerging to prevent early relapse, such as targeted therapy and immunotherapy. Investigation on predictive biomarkers of responses to adjuvant and neoadjuvant therapies is also continuously ongoing. Immunotherapy represented by immune checkpoint inhibitors (ICIs), either by monotherapy or in combination with chemotherapy, has shown benefit in promoting pathological responses and prolonging survival for patients with NSCLC without oncogenic mutations. Exploratory studies have also provided evidence regarding the selection of patients who benefit from ICI‐based perioperative treatment. This review focuses on the existing data of current clinical trials of adjuvant and neoadjuvant strategies with ICIs in resectable NSCLC, the exploration of predictive biomarkers, and the perspectives and urgent challenges in the future.
Multi‐feature subspace representation network for person re‐identification via bird's‐eye view image
Authors: Zhang Jiwei , Wu Haiyuan , Chen Qian , Hachiya Hirotaka 
Published: February 2023

AbstractPerson re‐identification (Re‐ID) is one of the most remarkable research topics that widely applied in our daily lives. For person Re‐ID in bird's eye scenes, traditional computer vision‐based methods used multiple features, for example, texture and color, of a pedestrian's head and shoulders. Those methods are difficult to cope with environments of variety and the change the appearance of different people due to the instability of feature detection. On the other hand, although recent advanced deep learning‐based methods are powerful to extract discriminative features, the requirement of a large amount of annotated training data restricts the appliable tasks. To overcome this problem, in this article, we propose a novel method fusing multiple heterogeneous features through a multi‐feature subspace representation network (MFSRN) to maximize the classification performance while keeping the disparity among features as small as possible, that is, common‐subspace constraints. We conducted comparative experiments with state‐of‐the‐art models on the bird's‐eye view person dataset, and extensive experimental results demonstrated that our proposed MFSRN could achieve better recognition performance. Furthermore, the validity and stability of the method are confirmed.
Chemical Composition, Toxicity and Repellency ofInula graveolensEssential Oils from Roots and Aerial Parts against Stored‐Product BeetleTribolium castaneum(Herbst)
Authors: Ben Mustapha Mayssa , Algethami Faisal K. , Elamin Mohamed R. , Abdulkhair Babiker Y. , Chaieb Ikbal , Ben Jannet Hichem 
Published: February 2023

AbstractIn this work, essential oils extracted from roots and aerial parts ofInula graveolensby hydrodistillation and their fractions obtained by chromatographic simplification were first investigated for their chemical composition by GC/MS and then evaluated for the first time for their repellency and contact toxicity properties againstTribolium castaneumadults. Twenty‐eight compounds were identified in roots essential oil (REO), which accounted for 97.9 % of the total oil composition, with modhephen‐8‐β‐ol (24.7 %),cis‐arteannuic alcohol (14.8 %), neryl isovalerate (10.6 %) and thymol isobutyrate (8.5 %) as major constituents. Twenty‐two compounds were found in the essential oil from aerial parts (APEO), which accounted for 93.9 % of the total oil, with borneol (28.8 %), caryophylla‐4(14),8(15)‐dien‐6‐ol (11.5 %), caryophyllene oxide (10.9 %), τ‐cadinol (10.5 %) and bornyl acetate (9.4 %) as main compounds.REO and APEO displayed stronger repellency after 2 h of exposure (80.0 and 90.0 %, respectively) againstT. castaneumat the concentration of 0.12 μL/cm2. After fractionation, fractions R4and R5exhibited greater effects (83.3 % and 93.3 %, respectively) than the roots essential oil. Furthermore, the fractions AP2and AP3showed higher repellency (93.3 and 96.6 %, respectively) than the aerial parts oil. The LD50values of oils from roots and aerial parts topically applied were 7.44 % and 4.88 %, respectively. Results from contact toxicity assay showed that fraction R4was more effective than the roots oil with LD50value of 6.65 %. These results suggests that essential oils of roots and aerial parts fromI. graveolensmay be explored as potential natural repellent and contact insecticides againstT. castaneumin stored products.
Determination of the Effects of Bee Venom on Triple Negative Breast Cancer Cells in Vitro
Authors: Sevin Sedat , Deveci Ozkan Asuman , Tutun Hidayet , Kivrak Ibrahim , Turna Ozge , Guney Eskiler Gamze 
Published: February 2023

AbstractHoneybees provide multiple products such as bee venom (BV) which are used for various nutritional and medicinal purposes. BV has received great attention due to its wide range of bioactive components with potential anti‐cancer effects on different cancers. Triple negative breast cancer (TNBC) is defined as an aggressive type of breast cancer and new therapeutic targets are required for its treatment. In the current literature information is varied about the composition and quantity of BV bioactive compounds as well as the origin of BV and its significance. In this context, the cytotoxic and apoptotic effects of BV with a higher rate of mellitin from Apis mellifera anatoliaca (Muğla ecotype) on MDA‐MB‐231 cells was evaluated, in vitro. The cytotoxic, apoptotic and morphological effects of BV were determined by WST‐1, Annexin V, cell cycle analysis and Acridine Orange staining. The results showed that BV caused apoptotic cell death in TNBC cells at a lower dose (0.47 μg/mL, p<0.01). This study suggests that BV could be developed as a potential therapeutic agent for cancer treatment. However, the mechanism of BV‐induced apoptosis death should be clarified at the molecular level.
Monocarbonyl Analogs of Curcumin with Potential to Treat Colorectal Cancer
Authors: Clariano Marta , Marques Vanda , Vaz João , Awam Salma , Afonso Marta B. , Jesus Perry Maria , Rodrigues Cecília M. P. 
Published: February 2023

AbstractCurcumin has a plethora of biological properties, making this compound potentially effective in the treatment of several diseases, including cancer. However, curcumin clinical use is compromised by its poor pharmacokinetics, being crucial to find novel analogs with better pharmacokinetic and pharmacological properties. Here, we aimed to evaluate the stability, bioavailability and pharmacokinetic profiles of monocarbonyl analogs of curcumin. A small library of monocarbonyl analogs of curcumin 1a–q was synthesized. Lipophilicity and stability in physiological conditions were both assessed by HPLC‐UV, while two different methods assessed the electrophilic character of each compound monitored by NMR and by UV‐spectroscopy. The potential therapeutic effect of the analogs 1a–q was evaluated in human colon carcinoma cells and toxicity in immortalized hepatocytes. Our results showed that the curcumin analog 1e is a promising agent against colorectal cancer, with improved stability and efficacy/safety profile.
Orbital emphysema as a result of chest tube placement for recurrent pneumothorax
Authors: Land Matthew Reese , Shin Eunice Hah‐eun , Kim Dooho Brian 
Published: February 2023

AbstractOrbital emphysema refers to the presence of air or gas within the orbital soft tissue space. Although orbital fracture due to trauma is the most common cause, iatrogenic orbital emphysema from chest tube insertion is a rare but potentially serious complication from the treatment of pneumothorax. Symptoms can range from mild crepitus of the periorbital region to permanent vision loss secondary to central retinal artery occlusion or optic neuropathy, a result of orbital compartment syndrome. Management is dependent on the presence of orbital signs and vision loss. Herein, we present a rare case of orbital emphysema in the setting of pneumothorax and chest tube insertion in a 62 year‐old patient admitted to the hospital floor. Presenting symptoms included vision loss and bilateral orbital edema, while physical exam revealed complete ptosis of the right eye with diffuse periorbital emphysema and crepitus. Diagnosis was confirmed clinically and with CT head and orbits. The patient's vision loss was felt to be secondary to ptosis; thus, interventions were not necessary and his condition resolved with observation. The present case and associated literature review highlights orbital emphysema as a complication of chest tube insertion and pneumothorax, as well as the drastic complications of the condition if left untreated.
Aqueous‐Phase Partial Oxidation of Methane over Pd−Fe/ZSM‐5 with O2 in the Presence of H2
Authors: Yang Gun Sik , Kang Jongkyu , Park Eun Duck 
Published: February 2023

AbstractThe selective oxidation of methane into methane oxygenates such as CH3OH and HCOOH with O2 is a promising technology for direct methane conversion. This study successfully demonstrates the partial oxidation of methane over Pd−Fe/ZSM‐5 catalysts in water, where H2O2 was generated in situ from H2 and O2. A low Pd content is essential for preventing agglomeration of Pd nanoparticles, and intimate contact between Pd and Fe species is beneficial for achieving high yields of methane oxygenates. This one‐body catalyst showed better catalytic performance than that of previously reported ones, especially at low temperatures. 0.28 %Pd–0.56 %Fe/ZSM‐5 exhibited a stable catalytic performance in a continuous flow reactor.
Construction of Nitrogen‐Doped Carbon Functionalized Ni(OH)2 for Selective CO2 Photoreduction
Authors: Yang Zhidong , Zhang Hongxia , Zhao Jianghong , Shi Hu , Yang Pengju 
Published: February 2023

AbstractPhotoreduction of CO2 is a sustainable way of producing carbon‐neutral fuels. However, the development of robust catalyst for the selective reduction of CO2 to value‐added chemicals remains a challenge. Using a photochemical approach, encapsulation of nitrogen‐doped carbon and Ni(OH)2 is to form a hybrid (Ni(OH)2/NC) for photocatalytic CO2 reduction. The as‐synthesized Ni(OH)2/NC catalyst exhibits enhanced selectivity and activity for CO production under visible light. A CO evolution rate of 14.93 μmol h−1 with 84 % selectivity is achieved, outperforming the bare Ni(OH)2 (8.51 μmol h−1 evolution rate and 45 % selectivity for CO). The structures and physicochemical properties of the Ni(OH)2/NC were carefully analyzed by various characterization techniques and density functional theory (DFT) calculations. Results suggest that the NC modification can modulate the electronic structures of Ni(OH)2, and thus consolidate the adsorption and activation of CO2. Furthermore, the interface charge transfer between photosensitizer and Ni(OH)2 can also be promoted after NC modification. As a result, the Ni(OH)2/NC catalyst exhibits superior activity for CO2‐to‐CO photoreduction. Moreover, NC‐encapsulated NiO (NiO/NC) was successfully prepared under the same conditions. This NiO/NC catalyst also exhibits enhanced selectivity and activity for CO2 reduction with visible light, suggesting the effectiveness of carbon‐modification for managing CO2 reduction. This work provides a new avenue to modulate the selectivity and activity of CO2 reduction over transition metal hydroxides or oxide catalysts.
Ambivalence to action: Addressing systemic racism in counselor education
Authors: Hannon Michael D. , White Ebony E. , Fleming Halston 
Published: February 2023

AbstractCiting the ongoing and urgent need within counselor education to confront and disrupt systemic racism within the profession, we present how professional counseling has been both ambivalent to racism and enacted systematically racist policies against Black and other racially marginalized people. We share selected milestones in the profession's evolution to illustrate ambivalence in the pursuit of racial justice and close with recommendations to create a more inclusive, affirming, and antiracist profession for members and clients.
Stability of Catalytic Centres in Light‐Driven Hydrogen Evolution by Di‐ and Oligonuclear Photocatalysts
Authors: Lämmle Martin , Mengele Alexander K. , Shillito Georgina E. , Kupfer Stephan , Rau Sven 
Published: February 2023

AbstractA review. In recent decades, mimicking natural photosynthesis by artificial photocatalysis represented a major research direction with the ultimate goal of reducing fossil fuel consumption through efficient solar energy harvesting. To transfer molecular photocatalysis from the lab scale to an industrially relevant process, it is important to overcome instability problems of the catalysts during light‐driven operation. As it is well‐known that many of the typically utilized noble metal‐based catalytic centres (e. g. Pt and Pd) undergo particle formation during (photo)catalysis and thus switch the whole process from a homogeneous into a heterogeneous one, an understanding of the factors governing particle formation is crucially needed. The review therefore focuses on di‐ and oligonuclear photocatalysts bearing a range of different bridging ligand architectures for drawing structure‐catalyst‐stability relationships in light‐driven intramolecular reductive catalysis. In addition, ligand effects at the catalytic centre and their implications for catalytic activity in intermolecular systems will be discussed, as will important insights into the future design of operationally stable catalysts.
3D‐Printed Organic Conjugated Trimer for Visible‐Light‐Driven Photocatalytic Applications
Authors: Yuan Xiaojiao , Sunyer‐Pons Neus , Terrado Aleix , León José Luis , Hadziioannou Georges , Cloutet Eric , Villa Katherine 
Published: February 2023

AbstractSmall molecule organic semiconductors (SMOSs) have emerged as a new class of photocatalysts that exhibit visible light absorption, tunable bandgap, good dispersion, and solubility. However, the recovery and reusability of such SMOSs in consecutive photocatalytic reactions is challenging. This work concerns a 3D‐printed hierarchical porous structure based on an organic conjugated trimer, named EBE. Upon manufacturing, the photophysical and chemical properties of the organic semiconductor are maintained. The 3D‐printed EBE photocatalyst shows a longer lifetime (11.7 ns) compared to the powder‐state EBE (1.4 ns). This result indicates a microenvironment effect of the solvent (acetone), a better dispersion of the catalyst in the sample, and reduced intermolecular π−π stacking, which results in improved separation of the photogenerated charge carriers. As a proof‐of‐concept, the photocatalytic activity of the 3D‐printed EBE catalyst is evaluated for water treatment and hydrogen production under sun‐like irradiation. The resulting degradation efficiencies and hydrogen generation rates are higher than those reported for the state‐of‐the‐art 3D‐printed photocatalytic structures based on inorganic semiconductors. The photocatalytic mechanism is further investigated, and the results suggest that hydroxyl radicals (HO⋅) are the main reactive radicals responsible for the degradation of organic pollutants. Moreover, the recyclability of the EBE‐3D photocatalyst is demonstrated in up to 5 uses. Overall, these results indicate the great potential of this 3D‐printed organic conjugated trimer for photocatalytic applications.
An Indonesian slimming drug with undeclared ingredients causing harm
Authors: van de Koppel Sonja , Ekhart Corine , Roelen Chantal , Ohana Dana , Kooijman Martin , van Hunsel Florence 
Published: February 2023

AbstractThis paper reports the presence of undeclared drugs in the herbal slimming supplement Sulami®. The four cases of the adverse drug reactions related to Sulami® were reported to the Dutch Pharmacovigilance Centre (Lareb) or the Dutch Poisons Information Centre (DPIC). The analysis of all four collected samples revealed adulteration with sibutramine and canrenone. Both drugs can cause serious adverse drug reactions. From a legal point of view, it is clear that Sulami® does not meet the legal requirement for safety. As defined in the European General Food Law Regulation, food business operators are responsible for food safety. This also applies to online store owners who sell herbal preparations. Thus, it is clear that it is forbidden to sell Sulami® on the European and Dutch market. Collaboration between involved national authorities makes it possible to identify risky products. This allows the nationally responsible regulators to take targeted action. They can call on users to report sell points what makes it possible to arrest the sellers and confiscate the dangerous products. Beyond the national, also, the European enforcement organizations should take legal measures where possible, to protect public health. The Heads of Food Safety Agencies Working Group on Food Supplements “an Initiative on European level” is a good example of efforts to improve consumer safety.
Relationship between right‐to‐left shunt, hypoxia, and epilepsy
Authors: Dong Bosi , Li Yajiao , Ji Shuming , He Shixu , Lai Qi , Yang Ximeng , Wang Hui , Tang Yusha , Peng Anjiao , Wu Min , Zhang Yunwu , Chen Lei 
Published: February 2023

AbstractObjectiveA right‐to‐left shunt (RLS) can mediate the hypoxic state, and hypoxemia is relevant for the development of drug‐resistant epilepsy (DRE). The objective of this study was to identify the relationship between RLS and DRE and further investigate the contribution of RLS to the oxygenation state in patients with epilepsy (PWEs).MethodsWe performed a prospective observational clinical study of PWEs who underwent contrast medium transthoracic echocardiography (cTTE) between January 2018 and December 2021 at West China Hospital. The collected data included demographics, clinical features of epilepsy, antiseizure medications (ASMs), RLS identified by cTTE, electroencephalography (EEG), and magnetic resonance imaging (MRI). Arterial blood gas was also assessed in PWEs with or without RLS. The association between DRE and RLS was quantified using multiple logistic regression, and the parameters of oxygen levels were furtherly analyzed in PWEs with or without RLS.ResultsA total of 604 PWEs who completed cTTE were included in the analysis, of which 265 were diagnosed with RLS. The proportion of RLS was 47.2% in the group of DRE, and the proportion of RLS was 40.3% in the group of non‐DRE. Having RLS was associated with DRE in multivariate logistic regression analysis (adjusted OR = 1.53, P = 0.045). In the analysis of blood gas, the partial oxygen pressure in PWEs with RLS was lower than those without RLS (88.74 mmHg versus 91.84 mmHg, P = 0.044).SignificanceRight‐to‐left shunt could be an independent risk factor of DRE, and low oxygenation might be a possible reason.
Internet gaming disorder and tobacco use disorder share neural connectivity patterns between the subcortical and the motor network
Authors: Chen Hui , Zha Rujing , Lai Xin , Liu Yan , Wei Zhengde , Wang Min , Zuo Huilin , Hong Wei , Fan Chuan , Jin Chen , Cui Guanbao , Tao Ran , Liang Peipeng , Zhang Xiaochu 
Published: February 2023

AbstractInternet gaming disorder (IGD) and tobacco use disorder (TUD) are globally common, non‐substance‐related disorders and substance‐related disorders worldwide, respectively. Recognizing the commonalities between IGD and TUD will deepen understanding of the underlying mechanisms of addictive behavior and excessive online gaming. Using node strength, 141 resting‐state data were collected in this study to compute network homogeneity. The participants included participants with IGD (PIGD: n = 34, male = 29, age: 15–25 years), participants with TUD (PTUD: n = 33, male = 33, age: 19–42 years), and matched healthy controls (control‐for‐IGD: n = 41, male = 38, age: 17–32 years; control‐for‐TUD: n = 33, age: 21–27 years). PIGD and PTUD exhibited common enhanced node strength between the subcortical and motor networks. Additionally, a common enhanced resting‐state functional connectivity (RSFC) was found between the right thalamus and right postcentral gyrus in PIGD and PTUD. Node strength and RSFC were used to distinguish PIGD and PTUD from their respective healthy controls. Interestingly, models trained on PIGD versus controls could classify PTUD versus controls and vice versa, suggesting that these disorders share common neurological patterns. Enhanced connectivity may indicate a greater association between rewards and behaviors, inducing addiction behaviors without flexible and complex regulation. This study discovered that the connectivity between the subcortical and motor networks is a potential biological target for developing addiction treatment in the future.
Comparison of real‐world outcomes following immunotherapy in recurrent or metastatic head and neck squamous cell carcinoma with outcomes of randomized controlled trials
Authors: Yalamanchali Anirudh , Yang Kailin , Roof Logan , Lopetegui‐Lia Nerea , Schwartzman Larisa M. , Campbell Shauna R. , Woody Neil M. , Silver Natalie , Koyfman Shlomo , Geiger Jessica L. , Yilmaz Emrullah 
Published: February 2023

AbstractObjectivesEvaluate outcomes of patients with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy (IO).MethodsAmong patients with R/M HNSCC treated with IO in this retrospective single‐institution cohort, Cox regression was used to compare overall survival (OS) for those with platinum‐refractory disease and those treated in the first‐line setting with OS from KEYNOTE‐040/048, respectively. Multivariable Cox regression was used to identify predictors of OS.ResultsThere was no significant OS difference for those treated in the platinum‐refractory setting when compared to patients on KEYNOTE‐040 (HR = 1.22, p = 0.27), nor for the first‐line setting compared to KEYNOTE‐048 (HR = 1.23, p = 0.19). ECOG‐PS 1 (HR = 2.00, p = 0.02) and ECOG‐PS 2 (HR = 3.13, p < 0.01) were associated with worse OS. Higher absolute lymphocyte count (ALC) was associated with improved OS (HR = 0.93 per 100 cells/μL, p = 0.03).ConclusionsReal‐world outcomes of IO in R/M HNSCC are similar to outcomes in randomized control trials, with performance status and ALC correlating with OS.