bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Reconstruction of Helical Iron Borophosphate Precatalyst toward Durable Industrial Alkaline Water Electrolysis and Selective Oxidation of Alcohols
Authors: Yang Hongyuan , Vijaykumar Gonela , Chen Ziliang , Hausmann J. Niklas , Mondal Indranil , Ghosh Suptish , Nicolaus Victor C. J. , Laun Konstantin , Zebger Ingo , Driess Matthias , Menezes Prashanth W. 
Published: June 2023

AbstractIron‐based (pre)catalysts have attracted enormous attention for various electrooxidation reactions due to the low cost, high abundance, and multiple accessible redox states of iron. Herein, a well‐defined helical iron borophosphate (LiFeBPO) is developed as an electro(pre)catalyst for the oxygen evolution reaction (OER) and selective alcohol oxidation. When deposited on nickel foam (NF), LiFeBPO exhibits an exceptional OER performance at ambient conditions attaining a current density of 100 mA cm−2 at ≈276 mV overpotential in 1 m KOH. Notably, this anode sustains durable alkaline water electrolysis at 500 mA cm−2 for over 330 h under industrial conditions (6 m KOH and 85 °C). In –situ and ex situ investigations reveal a deep reconstruction of LiFeBPO during OER, which transforms into a 3D open porous skeleton assembled by ultrasmall, low‐crystalline α‐FeOOH nanoparticles (interfacing with NiOOH of NF). This structure contributes to exposing accessible surface active sites, as well as accelerating mass transport and bubble detachment. Moreover, this electrode also catalyzes the electrooxidation of alcohols (methanol, ethylene glycol, and glycerol) to formic acid (FA) with high selectivity and full conversion. This study provides promising solutions for designing suitable anodes for the simultaneous production of green hydrogen fuel and value–added FA from electrooxidation reactions.
Excellent Liquid Unidirectional Transport Inner Tilted‐Sector Arrayed Tubes
Authors: Liu Yihe , Zhan Haiyang , He Xixing , Zhang Mengfan , Xue Juncheng , Ouyang Tianhao , Zhao Lei , Liu Yahua , Feng Shile 
Published: June 2023

AbstractLiquid unidirectional transport exhibits critical applications from water harvesting to microfluidics. Despite extensive progress, implementation of liquid unidirectional transport that is not subjected to the liquid surface tension and injecting velocity also remains a great challenge. Here, a tilted‐sector arrayed tube for excellent liquid unidirectional transport is proposed that applies to a vast width domain of liquid surface tension and injecting velocity. In addition, the transport direction is abnormally against the tilted direction of structure, in stark contrast to the traditional understanding that is along tilted direction. This excellent and unique liquid unidirectional transport is caused by synergistic effects of tilted sectors and tube structures, which induce a unique 3D liquid propagation mode as well as a large Laplace pressure asymmetry between the front and rear sides of the liquid. Moreover, the antigravity climbing, circuit isolating, and chemical reaction controlling can be achieved based on the excellent liquid unidirectional transport. It is envisioned that the design can be extensively applied in microfluidics, lab‐on‐a‐chip devices, and biochemistry microreactors.
Tracing the Effects of Nitrogen Doping and Sulfur Vacancy in Surging OER Electrocatalytic Activity of Bismuth Sulfide Nanorods
Authors: Zeng He , Lv Miao , Wang Hui , Li Xin , Jin Shengming , Liu Zhiliang , Chang Xinghua 
Published: June 2023

AbstractBismuth sulfide has become an attractive candidate in the electrocatalytic oxygen evolution reaction (OER), owing to its open coordination sites, unpaired electron orbitals, and mild electronegativity, but its OER performance is hindered by many deficiencies. The combination of heteroatom construction and vacancy engineering has been used to improve the OER performance of bismuth‐based electrocatalysts, but few studies can clearly describe the roles of dopants and vacancies in improving OER performance. Herein, N dopants and S vacancies in Bi2S3 nanorods via one‐step NH3/Ar plasma etching to investigate the enhanced OER performance are constructed. N dopants and S vacancies both regulated the intrinsic charge ordering of Bi2S3 nanorods, enhancing the p‐band center and Fermi level while also boosting the electroconductivity and wettability of the material. In addition, density functional theory calculations suggest that N doping promoted the adsorption of Bi sites, while S vacancies favored the desorption of S sites. Under the synergistic effects of N dopants and S vacancies, Bi2S3‐based electrocatalysts exhibited a low overpotential of 374 mV at 10 mA cm−2 and satisfactory durability, demonstrating a feasible strategy for exploiting main group element OER electrocatalysts.
HCV Core Protein–ISX Axis Promotes Chronic Liver Disease Progression via Metabolic Remodeling and Immune Suppression
Authors: Wang Li‐Ting , Wang Shen‐Nien , Chiou Shyh‐Shin , Tsai Jhih‐Peng , Chai Chee‐Yin , Tseng Li‐Wen , Lee Jin‐Ching , Lin Ming‐Hong , Huang Shau‐Ku , Hsu Shih‐Hsien 
Published: June 2023

AbstractChronic hepatitis C virus (HCV) infection is an important public health issue. However, knowledge on how the virus remodels the metabolic and immune response toward hepatic pathologic environment is limited. The transcriptomic and multiple evidences reveal that the HCV core protein–intestine‐specific homeobox (ISX) axis promotes a spectrum of metabolic, fibrogenic, and immune modulators (e.g., kynurenine, PD‐L1, and B7‐2), regulating HCV‐infection relevant pathogenic phenotype in vitro and in vivo. In a transgenic mice model, the HCV core protein–ISX axis enhance metabolic disturbance (particularly lipid and glucose metabolism) and immune suppression, and finally, chronic liver fibrosis in a high‐fat diet (HFD)‐induced disease model. Mechanistically, cells with HCV JFH‐1 replicons upregulate ISX and, consequently, the expressions of metabolic, fibrosis progenitor, and immune modulators via core protein‐induced nuclear factor‐κB signaling. Conversely, cells with specific ISX shRNAi inhibit HCV core protein‐induced metabolic disturbance and immune suppression. Clinically, the HCV core level is significantly correlated with ISX, IDOs, PD‐L1, and B7‐2 levels in HCC patients with HCV infection. Therefore, it highlights the significance of HCV core protein–ISX axis as an important mechanism in the development of HCV‐induced chronic liver disease and can be a specific therapeutic target clinically.
Logic‐In‐Memory Characteristics of Reconfigurable Feedback Field‐Effect Transistors with Double‐Gated Structure
Authors: Shin Yunwoo , Son Jaemin , Jeon Juhee , Cho Kyoungah , Kim Sangsig 
Published: June 2023

AbstractThe reconfigurable feedback field‐effect transistors (R‐FBFETs) with a double‐gated structure are designed and the logic and memory operations of a logic‐in‐memory (LIM) inverter comprising two R‐FBFETs are investigated. The R‐FBFETs exhibit an extremely low subthreshold swing of ≈1 mV dec−1, a high on/off current ratio of ≈107, and a long retention time of 10 s, owing to a positive feedback loop mechanism. The on‐current ratio of the p‐ to n‐channel modes is 1.03, which indicates a high degree of reconfigurability. The LIM inverter retains the output logic “1” and “0” states for over 50 s under zero‐bias conditions. The symmetric reconfigurable switching and memory operations of the R‐FBFETs enable the LIM inverter to perform logic and memory operations for a long retention time without a power supply.
Palladium‐Catalyzed Carbonylative Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates
Authors: Zhang Pengpeng , Newhouse Timothy R. 
Published: June 2023

AbstractThis report describes the first example of palladium‐catalyzed carbonylative difunctionalization of unactivated alkenes initiated by enolate nucleophiles. The approach involves initiation by an unstabilized enolate nucleophile under an atmospheric pressure of CO and termination with a carbon electrophile. This process is compatible with a diverse range of electrophiles, including aryl, heteroaryl, and vinyl iodides to yield synthetically useful 1,5‐diketone products, which were demonstrated to be precursors for multi‐substituted pyridines. A PdI‐dimer complex with two bridging CO units was observed although its role in catalysis is not yet understood.
Why is there no service to support taxonomy?
Authors: Sigwart Julia D. , Chen Chong , Tilic Ekin , Vences Miguel , Riehl Torben 
Published: June 2023

AbstractIncreasing complexity and specialisation of modern sciences has led to increasingly collaborative publications, as well as the involvement of commercial services. Modern integrative taxonomy likewise depends on many lines of evidence and is increasingly complex, but the trend of collaboration lags and various attempts at ‘turbo taxonomy’ have been unsatisfactory. We are developing a taxonomic service in the Senckenberg Ocean Species Alliance to provide fundamental data for new species descriptions. This will also function as a hub to connect a global network of taxonomists, assembling an alliance of scientists working on potential new species to tackle both the extinction and inclusion crises we face today. The current rate of new species descriptions is simply too slow; the discipline is often dismissed as old fashioned, and there is a crisis level need for taxonomic descriptions to come to grips with the scale of Anthropocene biodiversity loss. Here, we envision how the process of describing and naming species would benefit from a service supporting the acquisition of descriptive data. Also see the video abstract here: https://youtu.be/E8q3KJor_F8
Glucose metabolism and function of CD4+ Tregs are regulated by the TLR8/mTOR signal in an environment of SKOV3 cell growth
Authors: Wu Ming , Fu Xin , Xu Rui , Liu Shuna , Li Rong , Xu Juan , Shang Wenwen , Chen Xian , Wang Ting , Wang Fang 
Published: June 2023

AbstractPurposeTo investigate the role of mammalian target of rapamycin (mTOR) signal in Toll‐like receptor (TLR) 8‐mediated regulation of glucose metabolism and its effect on reversing immunosuppression in CD4+ regulatory T‐cells (Tregs) in ovarian cancer (OC).MethodsFluorescence‐activated cell sorting was used to detect the expression levels of mTOR+ and 4E‐BP1+ cells in CD4+ Tregs. The prognosis and immune infiltration analysis of mTOR mRNA in OC were performed using the TIMER and Kaplan–Meier plotter database. Furthermore, real‐time polymerase chain reaction (RT‐PCR) and western blot (WB) were used to detect expression levels of glucose metabolism‐related genes and proteins in CD4+ Tregs. Glucose uptake and glycolysis levels were detected by colorimetry, while the effects of CD4+ Tregs on the proliferation of CD4+ T‐effector cells (Teffs) were evaluated by carboxyfluorescein diacetate succinimidyl ester (CFSE).ResultsmTOR expression in CD4+ Tregs was significantly higher in patients with OC compared with controls and in CD4+ Tregs than in CD4+ Teffs in OC. Additionally, the expression level of mTOR mRNA was related to prognosis and immune infiltration levels in patients with OC. Blocking the mTOR signal resulted in downregulation of glucose metabolism in CD4+ Tregs. Simultaneous inhibition of the mTOR signal while activation of the TLR8 signal had a coordinated inhibitory effect on glucose metabolism and the immunosuppressive function of CD4+ Tregs. Furthermore, the mTOR signal played an essential role in TLR8‐mediated reversal of immunosuppressive function in CD4+ Tregs.ConclusionThese findings imply that activation of the TLR8 signal inhibits glucose metabolism in CD4+ Tregs by downregulating mTOR signaling, thereby reversing the immunosuppressive function of these cells in an OC cell growth environment.
Ultrasound‐guided hookwire localization of non palpable cervical lymphadenopathy: A case–control study of operative time
Authors: Bran William , Sahli‐Vivicorsi Sonia , Cadieu Romain , Alavi Zarrin , Leclere Jean‐Christophe 
Published: June 2023

AbstractObjectiveWe aimed at evaluating the impact of ultrasound‐guided (US) hookwire localization of nonpalpable cervical lymphadenopathy on operating time.Design and MethodsRetrospective case control study (January 2017 and May 2021) of 26 patients with lateral nonpalpable cervical lymphadenopathy undergoing surgery with (H+) and without (H−) per operative US‐guided hook‐wire localization. Operative time (general anesthesiology onset, hookwire placement, end of surgery) and surgery‐related adverse events data were collected.ResultsMean operative time was significantly shorter in H+ group versus H− group (26 ± 16 min vs. 43 ± 22 min) (p = 0.02). Histopathological diagnosis accuracy was 100% versus 94% (H+ vs. H−, p = 0.1). No significant between group difference in surgery‐related adverse events was reported (wound healing, p = 0.162; hematomas, p = 0.498; neoplasms removal failure, p = 1).ConclusionUS‐guided hookwire localization of lateral nonpalpable cervical lymphadenopathy allowed a significant reduction in operative time, comparable histopathological diagnosis accuracy and adverse events compared with H−.
Delayed perforation of an atrial pacemaker electrode: Lifelong risk for a rare but serious complication
Authors: Waechter Christian , Koenig Alexander M. , Chatzis Georgios , Mueller Julian , Schieffer Bernhard , Luesebrink Ulrich 
Published: June 2023

Key Clinical MessageNonspecific symptoms such as pleuritic or pericardial chest pain in cardiovascular implantable electronic devices patients, even with unremarkable ECG or device parameters, should always raise suspicion of electrode perforation, regardless of how long ago the implantation was performed.AbstractWe report the successful percutaneous management of a 77‐year‐old woman who had a dual‐chamber pacemaker implanted more than 1 year ago and presented with pericarditis pain and compensated pericardial hemorrhagic tamponade. The symptoms were due to very late acute perforation of the atrial lead. This report is intended to raise awareness of procedure‐related complications in the large group of cardiovascular implantable electronic device patients. Pleuritic or pericardial pain in these patients should raise suspicion of electrode perforation, as the risk of perforation is not restricted to the period immediately after implantation and a lifelong risk cannot apparently be excluded.
Parapharyngeal hematoma following transesophageal echo in a patient with hemophilia A
Authors: McKenna Dominic , Pampu Teodora , Korda Marian , Benson Gary 
Published: June 2023

Key Clinical MessageHemophilia A is an X‐linked disorder caused by deficiency of Factor VIII. Postoperative patients with mild hemophilia A, or those requiring intensive factor replacement, should be proactively screened for factor inhibitor development. This is a major complication of factor replacement that can induce severe factor resistant coagulopathy and life‐threatening bleeding.
Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality?
Authors: Du Juan , Liu Xuelai , Wong Carol Wing Yan , Wong Kenneth Kak Yuen , Yuan Zhixin 
Published: June 2023

AbstractInduced pluripotent stem cell (iPSC) technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years. Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs. Researchers have found that fibroblasts can be induced into different types of cells in variable mediums or microenvironments. This indicates the potential “stem” characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC detour. In this review, we described the morphology and biological function of fibroblasts. The stem cell characteristics and activities of fibroblasts, including transdifferentiation into myofibroblasts, osteogenic cells, chondrogenic cells, neurons, and vascular tissue, are discussed. The biological values of fibroblasts are then briefly reviewed. Finally, we discussed the potential applications of fibroblasts in clinical practice.
Sex different abdominal artery anatomy may induce different displacement force on stent‐graft after endovascular aneurysm repair
Authors: Teng Anna , Sun Anqiang , Chen Zengsheng , Deng Xiaoyan , Fan Yubo 
Published: June 2023

AbstractWomen with abdominal aortic aneurysm (AAA) have a higher incidence of complications after Endovascular aneurysm repair (EVAR), most of which are related to the migration of stent‐graft. The different force acting on the stent‐graft after EVAR caused by different abdominal artery anatomy of male and female AAA patients may be the reason for the sex‐different complications. This article aims to explore the possible biomechanical mechanisms of sex differences by making a comparison of displacement force acting on the stent graft of male and female AAA patients. To explore the effect of different vascular anatomy on stent‐graft migration, the uniformed models were constructed according to the specific vascular anatomy parameters of AAA patients of different sex, which have been measured before. The computational fluid dynamics method was used to quantitate the pulsatile force acting on the stent‐graft after EVAR in a cardiac cycle. Then the displacement force was calculated with the pressure and the wall shear stress, and the total and area‐weighted average of displacement force acting on the stent‐graft were compared respectively. In one cardiac cycle, the wall pressure for the male model is greater than that of the female model (2.7–4.4 vs. 2.2–3.4 N), and the wall shear force for the female model is slightly greater (0–0.0065 vs. 0–0.0055 N). The displacement force is mainly provided by the wall pressure, which is also greater in the male model. However, the area‐averaged displacement force is greater for the female model than that for the male model (180–290 vs. 160–250 Pa). Because of the different vascular anatomies, the impact caused by the pulsating aortic blood flow on the AAA stent‐graft of women after EVAR was greater than that of men. Women's vascular anatomy leads to greater area‐averaged displacement force after stent‐graft implantation, resulting in a greater risk of stent‐graft migration, which might be one of the reasons why women had a higher incidence of complications after EVAR.
Association between a hospitalization for heart failure and the initiation/discontinuation of guideline‐recommended treatments: An analysis from the Swedish Heart Failure Registry
Authors: Schrage Benedikt , Lund Lars H. , Benson Lina , Braunschweig Frieder , Ferreira João Pedro , Dahlström Ulf , Metra Marco , Rosano Giuseppe M.C. , Savarese Gianluigi 
Published: June 2023

AimsTo investigate whether a heart failure (HF) hospitalization is associated with initiation/discontinuation of guideline‐directed medical HF therapy (GDMT) and consequent outcomes.Methods and resultsAmong patients in the Swedish HF registry with an ejection fraction <50% enrolled in 2009–2018, initiation/discontinuation of GDMT was investigated by assessing dispensations of GDMT in those with versus without a HF hospitalization. Of 14 737 patients, 6893 (47%) were enrolled when hospitalized for HF. Initiation of GDMT was more likely than discontinuation following a HF hospitalization compared to a control group of patients without a HF hospitalization (odds ratio range 2.1–4.0 vs. 1.4–1.6 for the individual medications), although the proportion of patients not on GDMT was still high (8.1–44.0%). Key patient characteristics triggering less use of GDMT (i.e. less initiation or more discontinuation) were older age and worse renal function. Following a HF hospitalization, initiation of renin–angiotensin system inhibitors/angiotensin receptor–neprilysin inhibitors or beta‐blockers was associated with lower and their discontinuation with higher mortality risk, but no association with mortality was observed for initiation/discontinuation of mineralocorticoid receptor antagonists.ConclusionsFollowing a HF hospitalization, initiation of GDMT was more likely than discontinuation, although still limited. Perceived or actual low tolerance were barriers to GDMT implementation. Early re‐/initiation of GDMT was associated with better survival. Our findings represent a call for further implementing the current guideline recommendation for an early re‐/initiation of GDMT following a HF hospitalization.
Analysis of select utilities passing fuel costs and risks onto customers
Authors: Gakpetor Godfred , Shober Maggie 
Published: June 2023

AbstractAn electric utility bill often includes a fuel adjustment clause (FAC) charge that can be changed up or down to recoup the utility's fuel costs. The fuel adjustment clause was first introduced after fluctuations in coal prices during World War 1. The continued use of the FAC, which shifts the risk of fuel price spikes to the customer, is particularly concerning where energy burdens for vulnerable residents are high. To estimate the impact of an increase in natural gas prices on residential electricity bills because of the rise in the use of gas to generate energy in recent years. In 2020, electricity production accounted for around 33% of gas usage. One approach to address the high‐energy burden is providing clean and efficient energy for households, reducing energy bills, and freeing up household resources for other necessities. To determine this; first, a few utilities were selected, then the residential rate schedules were examined so a model could be built to calculate the bill based on a range of usage levels. The selected utilities, Florida Power & Light, Duke Energy Florida, Duke Energy Progress, and Duke Energy Carolinas, all rely on different fuel mixes to serve customers. Our findings suggest that with a heavy reliance on gas and a direct pass‐through of gas prices to customers, customers bear the risks of the volatile gas market. A slight increase in electric bills can have an outsized impact on customers, particularly low‐income households and individuals on fixed incomes.
The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis
Authors: Hao Rili , Zhou Xing , Lv Xiaqing , Zhu Xiangyang , Jiang Yang , Li Dapeng 
Published: June 2023

AbstractCadmium (Cd) is a heavy metal toxic that can cause health problems including lung injury. This study was set out to meet the growing demand for effective treatment of lung diseases and explore the mechanism of caffeic acid phenethyl ester (CAPE, a natural phenolic acid) protect against Cd‐caused lung damage. In this study, CAPE significantly increased mice body weight, decreased lung W/D ratio, and alleviated histomorphological injury. CAPE mitigated CdCl2‐induced oxidative stress through Nrf2/HO‐1/NQO1 pathway, suppressed inflammation via MyD88/NF‐κB pathway, and alleviated apoptosis by modulating apoptosis mediators. CAPE also inhibited the CdCl2‐caused decreasing of TLR4 level and the increasing of miR‐182‐5p level, which is achieved by miR‐182‐5p sponging TLR4. Collectively, miR‐182‐5p is involved in CAPE against CdCl2‐caused lung damage by targeting TLR4. MiR‐182‐5p/TLR4 is a new pathway for inhibiting oxidative stress, apoptosis, and inflammation in CAPE‐mediated lung protection, which provides a novel avenue for treatment therapies.