bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors Associated with Newborn Hearing Impairment in the Neonatal ICU of a Tertiary Hospital
Authors: Shameem Md , Saha Kanu Lal , Uddin Md Belal , Jahan Jesmin , Rahman Md Khalilur , Islam KM Saiful 
Published: January 2023

Introduction: Hearing impairment has a devastating, detrimental, and adverse impact on the development of the newborn. Unfortunately, this hidden disability remains undetected for many newborns until it is too late to prevent undesirable and often irreversible damage. It has long been recognized that undiagnosed hearing loss, even a mild loss at birth, can negatively affect speech and language development, Resulting in poor academic achievement and social-emotional development. According to WHO 2009, newborns in the NICU are 10-20 times at higher risk of developing hearing loss. The risk factors associated with newborn hearing impairment vary from country to country and even within countries. There has been a paucity of studies on this topic from Bangladesh. This study was done to identify the risk factors associated with newborn hearing impairment in the study place. The objective of the study: To identify risk factors associated with newborn hearing impairment in the study group.
Methodology: A prospective observational study was conducted in the department of neonatology, BSMMU. After taking consent from the parents/guardians, a thorough history of these newborns, including particulars of the neonates, family history of hearing loss, treatment history, antenatal, natal, and postnatal history, was recorded in a data collection form. Newborn admitted to the NICU during the study period was the study population. The newborn who meet the inclusion criteria was screened with Transient Evoked Otoacoustic Emissions (TEOAE) close to discharge from the NICU or before one month of age. A second screen was done with TEOAE again after one month of 1st screen but prior to 3 months of postnatal age if referred in 1st screen. Diagnostic Auditory Brain stem Response (ABR) was made to confirm the hearing impairment, and it was done prior to 3 months of postnatal age if referred in both the 1st and 2nd screens. Data were analyzed by statistical package for social sciences (SPSS) version 20.
Results: 426 valid recordings from 493 newborns admitted in the NICU enrolled consecutively constitute the basis of this study. 14 newborns were found to have hearing impairment among 426 newborns. APGAR ≤ 6 at 5 minutes (odds ratio 20.34, p-value 0.01), TORCH infection (odds ratio 0.64, p-value 0.01), IUGR odds ratio 8.92, p-value 0.02) were independent significant risk factors for hearing impairment.
Conclusion: APGAR ≤ 6 at 5 minutes, TORCH infection, and IUGR are independent significant risk factors for newborn hearing impairment. Newborns in NICU with these risk factors should have mandatory audiological evaluation.
TAJ 2022; 35: No-2: 59-65
Diagnosis of Enteric Fever Cases: Current Challenges of Azithromycin Resistant R717Q Gene in Rajshahi, Bangladesh
Authors: Sazzad Jarin , Alam Md Shah , Das Haimanti Shukla , Rahman Nahreen , Haque Quazi Tamanna , Rahman Kazi Mohaimenur 
Published: January 2023

Salmonella enterica serovars typhi is a contributing typhoid agent, leading to untreatable infections based upon the rising prevalence of antimicrobial resistance in the said agent. Consequently, the main concern of the health service providers to treat expansively drug-resistant (XDR) enteric fever has been dependent on the only remaining oral drug, Azithromycin, for creating emerging resistance against it. Therefore, a cross-sectional descriptive study was conducted in the Microbiology Department of Rajshahi Medical College, Rajshahi, to identify Salmonella species by Fastidious Antibiotic Neutralization (FAN) method in suspected enteric fever cases along with its antimicrobial susceptibility pattern and molecular detection of Azithromycin resistant R717Q gene. Samples were collected purposively. Regarding the population's age distribution, out of 127 specimens, the predominant 37(29.1%) were found within the age group of 35-44 years. Automated blood culture was found positive in 64(50.39%) population; out of them, Salmonella spp were 38(59.37%) of the population. Among them 29(76.31%) have travel history, took street food 25(65.7%), used tap water for drinking 21(55.2%) and had kancha latrine 24(63.1%). It was found that 18.43% were sensitive and 81.57% resistant to Azithromycin. Azithromycin-resistant Salmonella spp. were detected in 31(81.57%), and among Azithromycin resistant R717Q gene was identified in 9(29.03%). The azithromycin-resistant R717Q gene was identified by conventional PCR. Because of its oral course of administration, Azithromycin is considered the widely used drug in Bangladesh, which is used once on a dose basis a day. In order to contribute to the development of this drug resistance, there could be many reasons, and among them there are the availability over the counter and the imperfectly done treatment. Thus, this study would be helpful to formulate a regional hospital empirical therapy by antimicrobial sensitivity and resistance pattern of the gene for Azithromycin resistance in Rajshahi Medical College Hospital.
TAJ 2022; 35: No-2: 67-73
La evaluación digital educativa en los procesos de aprendizaje: estudio de caso de la unidad educativa Juan Antonio Vergara Alcívar
Authors: Demera-Zambrano Kleyner , López-Vera Liseth , Zambrano-Ormaza Denny , Nevárez-Zambrano Yilainy , Moreira-Chavesta Kenia 
Published: January 2023

La actual sociedad del conocimiento está rodeada de entornos digitales que exigen habilidades específicas para desenvolverse en ellos. Todo esto conlleva a una evolución digital, a un cambio que se desarrolla de manera continua en diferentes ritmos, contextos y ámbitos. Siendo la parte educativa, una de las más afectadas por estas transformaciones, que en muchos casos supone una problemática para docentes y estudiantes que poseen pocas o nulas competencias digitales. Por esta razón, este trabajo tiene como objetivo analizar la evaluación digital en los procesos de aprendizaje de la Unidad Educativa Juan Antonio Vergara Alcívar. En este estudio se utilizó la investigación bibliográfica de tipo descriptiva, con un enfoque cuali-cuantitativo. Se aplicó los métodos analítico-sintético e inductivo-deductivo y método estadístico. Como instrumento de recolección de datos se aplicó una encuesta con preguntas de opción múltiple a una muestra de 30 docentes. Los resultados obtenidos concluyen que los docentes aplican la evaluación digital en el proceso de aprendizaje, obteniendo múltiples beneficios para mejorar la calidad de la educación, sin embargo; el porcentaje de su uso sigue siendo bajo, limitando así el desarrollo de habilidades y destrezas digitales en los alumnos. Por ende, es necesario que los docentes se capaciten temas de avaluación digital para dinamizar los procesos de adquisición de conocimientos.
INDONESIAN DIPLOMACY OF SOUTH-SOUTH COOPERATION TO ACHIEVE SUSTAINABLE DEVELOPMENT GOALS 2030
Authors: Hutabarat Leonard 
Published: January 2023

South-South Cooperation has played an important role in encouraging development in various countries through strategic programs, such as training, sending experts, providing grants, scholarships, infrastructure, as well as empowering women. Indonesia as one of the countries that plays an active role as a donor country is expected to increase its role in strengthening Indonesia's position as a new emerging donor so that it can improve Indonesia's image in international forums. Diplomacy carried out by Indonesia is part of a constructivism approach in the study of international relations related to the formation of perceptions and values that Indonesia will share with its cooperation partners. South-South Cooperation is not only part of Indonesia's national priority in The National Medium-Term Development Plan 2020-2024, but also provides benefits as a bridge between the needs of beneficiaries and Indonesia's interests, improves Indonesia's positive image in the region and globally, and is part of Indonesia's economic diplomacy. In the recovery after the COVID-19 pandemic, South-South Cooperation is expected to be a part of development cooperation form that can be one of the instruments for restoring conditions and building back better in achieving the goals of Sustainable Development Goals 2030.
Keywords: Diplomacy, Indonesia, South-South Cooperation, Sustainable Development Goals 2030
Profile of aeroallergen sensitizations in allergic patients living in southern Vietnam
Authors: Trinh Tu HK , Nguyen Phuong TM , Tran Tai T , Pawankar Ruby , Pham Duy L 
Published: January 2023

BackgroundClimatic and geographical characteristics may alter the plant distribution and thereby the patterns of allergens.ObjectiveTo evaluate the profile of allergen sensitization in patients in southern Vietnam and its association with allergic diseases.MethodsWe collected data of 423 patients who visited the Unit of Allergy and Clinical Immunology, University Medical Center, Vietnam from 2014 to 2021, from their medical records. Patients underwent skin prick tests to the 12 most common aeroallergens. Clinical evaluation and diagnosis of allergic diseases was done in consert with their allergen sensitization status.ResultsMites and cockroach were the most prevalent sensitizing allergens, with the sensitization prevalences as followed: Dermatophagoides farinae (Df) (59.8%), Dermatophagoides pteronyssinus (Dp) (50.4%), Blomica tropicalis (Bt) (49.6%), storage mites mix (10.4%), and cockroach (10.2%). Sensitization to Df was more predominant in males than in females (66% vs 54.1%). Dp-sensitized patients were younger than non-sensitized patients (29.01 ± 13.60 vs. 32.17 ± 14.89) whereas storage mites-sensitized patients were older than the non-sensitized groups (36.25 ± 13.53 vs. 28.76 ± 13.39) (p &lt; 0.05 for all). A considerable proportion of patients with urticaria, allergic rhinitis, and atopic dermatitis were sensitized to mites. Polysensitization to different species of house dust mites (Dp, Df) and storage mites (Bt) was prevalent among patients sensitized to any kind of mites.ConclusionsAmong people living in southern Vietnam, HDM mites, and cockroach were the predominant allergens. Further studies on the factors regulating the association between allergen sensitization with allergic diseases and polysensitization are crucial.
Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: A randomized, controlled, prospective study
Authors: Wu Zezhen , Zhang Bangzhou , Chen Fengwu , Xia Rongmu , Zhu Dan , Chen Baolong , Lin Aiqiang , Zheng Chuyan , Hou Ducheng , Li Xiaoyu , Zhang Shuo , Chen Yongsong , Hou Kaijian 
Published: January 2023

ObjectivesRecent studies have shown that fecal microbiota transplantation (FMT) improved the metabolic profiles of patients with type 2 diabetes mellitus (T2DM), yet the effectiveness in reversing insulin resistance and increasing metformin sensitivity in T2DM patients have not been reported. In this study, we evaluated the improvements of T2DM patients and their gut microbiota by FMT alone and FMT plus metformin.MethodsA total of 31 patients with newly diagnosed T2DM were randomized to intervention by metformin, FMT, or FMT plus metformin in the study. Patients were followed up at baseline and week 4 after treatment. Blood and stool samples were collected and subject to analyze clinical parameters and microbial communities by metagenomic sequencing, respectively.ResultsFMT alone and FMT plus metformin significantly improved the clinical indicators HOMA-IR and BMI in T2DM, besides fasting blood glucose, postprandial blood glucose, and hemoglobin A1c that were also controlled by metformin. Donor microbiota effectively colonized in T2DM with slightly higher colonization ration in FMT than FMT plus metformin within 4 weeks, resulting in increased microbial diversity and community changes from baseline after treatment. A total of 227 species and 441 species were significantly alerted after FMT and FMT plus metformin, respectively. FMT were significantly associated with the clinical parameters. Among them, Chlorobium phaeovibrioides, Bifidibacterium adolescentis and Synechococcus sp.WH8103 were potential due to their significantly negative correlations with HOMA-IR.ConclusionsFMT with or without metformin significantly improve insulin resistance and body mass index and gut microbial communities of T2DM patients by colonization of donor-derived microbiota.
Exploring the hidden connections between information channel use and pro-environmental behavior among recreational anglers of the shore-based shark fishery in Florida, United States
Authors: Guay Jessika D. , Brooks Jill L. , Chapman Jacqueline M. , Medd Hannah , Cooke Steven J. , Nguyen Vivian M. 
Published: January 2023

IntroductionShore-based shark fishing in Florida is a relatively low-cost and easy-access fishery which attracts a wide variety of experienced and inexperienced anglers leading to concerns about proper handling methods of captured fish that are released either voluntarily or to comply with regulations. Proper handling methods can help reduce post-release mortality among sharks, many of which are threatened with extinction. Therefore, we considered proper handling methods as a pro-environmental behavior, which has been linked with the use of different information channels to increase conservation knowledge.MethodsWe used data from an online questionnaire to understand where anglers of this fishery obtain information about fishing skills with a particular focus on fish handling techniques and best practices for catch-and-release. Then we included their main information channels in a series of hierarchical regression models with perceived conservation knowledge and support for fishery management to explain pro-environmental behavior regarding shark conservation.ResultsWe found that most anglers learned about shore-based shark fishing through interpersonal communications with friends and family, but typically use the internet to learn more about fishing skills. While information channel use was not significantly associated with pro-environmental behavior, it was significantly associated with support for fisheries management, which in turn was associated with pro-environmental behavior among respondents.DiscussionThese findings can inform public educational outreach efforts to spread awareness of proper handling techniques and reduce instances of post-release mortality in sharks.
Shared gene characteristics and molecular mechanisms of macrophages M1 polarization in calcified aortic valve disease
Authors: Qin Ming , Chen Qian , Li Ning , Xu Xiangyang , Wang Chuyi , Wang Guokun , Xu Zhiyun 
Published: January 2023

BackgroundCAVD is a common cardiovascular disease, but currently there is no drug treatment. Therefore, it is urgent to find new and effective drug therapeutic targets. Recent evidence has shown that the infiltration of M1 macrophages increased in the calcified aortic valve tissues, but the mechanism has not been fully elucidated. The purpose of this study was to explore the shared gene characteristics and molecular mechanisms of macrophages M1 polarization in CAVD, in order to provide a theoretical basis for new drugs of CAVD.MethodsThe mRNA datasets of CAVD and M1 polarization were downloaded from Gene Expression Omnibus (GEO) database. R language, String, and Cytoscape were used to analyze the functions and pathways of DEGs and feature genes. Immunohistochemical staining and Western Blot were performed to verify the selected hub genes.ResultsCCR7 and GZMB were two genes appeared together in hub genes of M1-polarized and CAVD datasets that might be involved in the process of CAVD and macrophages M1 polarization. CCR7 and CD86 were significantly increased, while CD163 was significantly decreased in the calcified aortic valve tissues. The infiltration of M1 macrophages was increased, on the contrary, the infiltration of M2 macrophages was decreased in the calcified aortic valve tissues.ConclusionThis study reveals the shared gene characteristics and molecular mechanisms of CAVD and macrophages M1 polarization. The hub genes and pathways we found may provide new ideas for the mechanisms underlying the occurrence of M1 polarization during CAVD process.
Bayesian network analysis of panomic biological big data identifies the importance of triglyceride-rich LDL in atherosclerosis development
Authors: Voros Szilard , Bansal Aruna T. , Barnes Michael R. , Narula Jagat , Maurovich-Horvat Pal , Vazquez Gustavo , Marvasty Idean B. , Brown Bradley O. , Voros Isaac D. , Harris William , Voros Viktor , Dayspring Thomas , Neff David , Greenfield Alex , Furchtgott Leon , Church Bruce , Runge Karl , Khalil Iya , Hayete Boris , Lucero Diego , Remaley Alan T. , Newton Roger S. 
Published: January 2023

IntroductionWe sought to explore biomarkers of coronary atherosclerosis in an unbiased fashion.MethodsWe analyzed 665 patients (mean ± SD age, 56 ± 11 years; 47% male) from the GLOBAL clinical study (NCT01738828). Cases were defined by the presence of any discernable atherosclerotic plaque based on comprehensive cardiac computed tomography (CT). De novo Bayesian networks built out of 37,000 molecular measurements and 99 conventional biomarkers per patient examined the potential causality of specific biomarkers.ResultsMost highly ranked biomarkers by gradient boosting were interleukin-6, symmetric dimethylarginine, LDL-triglycerides [LDL-TG], apolipoprotein B48, palmitoleic acid, small dense LDL, alkaline phosphatase, and asymmetric dimethylarginine. In Bayesian analysis, LDL-TG was directly linked to atherosclerosis in over 95% of the ensembles. Genetic variants in the genomic region encoding hepatic lipase (LIPC) were associated with LIPC gene expression, LDL-TG levels and with atherosclerosis.DiscussionTriglyceride-rich LDL particles, which can now be routinely measured with a direct homogenous assay, may play an important role in atherosclerosis development.Clinical trial registrationGLOBAL clinical study (Genetic Loci and the Burden of Atherosclerotic Lesions); [https://clinicaltrials.gov/ct2/show/NCT01738828?term=NCT01738828&amp;rank=1], identifier [NCT01738828].
Gender, ethnic, and socioeconomic differences in access to catheter ablation therapy in patients with atrial fibrillation
Authors: Hamade Hani , Jabri Ahmad , Mishra Pooja , Butt Muhammad Umer , Sallam Sherin , Karim Saima 
Published: January 2023

IntroductionFemale patients, patients from racial minorities, and patient with low socioeconomic status have been noted to have less access to catheter ablation for atrial fibrillation.MethodsThis is a cross-sectional, retrospective study using a large population database (Explorys) to evaluate the gender, racial and socioeconomic differences in access of catheter ablation therapy in patient with atrial fibrillation.ResultsA total of 2.2 million patients were identified as having atrial fibrillation and 62,760 underwent ablation. Females had ablation in 2.1% of cases while males received ablation in 3.4% of cases. Caucasians had ablation in 3.3% of cases, African Americans in 1.5% of cases and other minorities in 1.2% of cases. Individuals on medicaid underwent ablation in 1.6% of cases, individuals on medicare and private insurance had higher rates (2.8 and 2.9%, respectively). Logistic regression showed that female patients (OR 0.608, CI 0.597–0.618, p &lt; 0.0001), patients who are African American (OR 0.483, CI 0.465–0.502, p &lt; 0.0001), or from other racial minorities (OR 0.343, CI 0.332–0.355, p &lt; 0.0001) were less likely to undergo ablation. Patient with medicare (OR 1.444, CI 1.37–1.522, p &lt; 0.0001) and private insurance (OR 1.572, CI 1.491–1.658, p &lt; 0.0001) were more likely to undergo ablation.ConclusionFemale gender, racial minorities, low socioeconomic status are all associated with lower rates of catheter ablation in management of atrial fibrillation.
A regionally verified method for fusion indexes of gas outbursts in adjacent seams within close coal seam groups
Authors: Zhang Shuai 
Published: January 2023

To effectively solve the problem of regional verification of gas outbursts adjacent to close coal seam groups, a method of regional verification and index fusion of the working face was proposed to promote the general idea of advanced detection, index fusion, and the determination of the critical values, inspection, and verification. Based on the engineering background of Xiaotun Coal Mine and advanced geological exploration, drilled holes were arranged in key locations and consisted of small intervals between layers, thickened coal seams, and geological structural belts. Moreover, fusion indexes were selected according to the statistical analysis of laboratory tests and on-the-spot measurements, which can be used to determine that the critical value of the residual gas content of the fusion indexes of the six adjacent upper coal seams is 8 m3/t and K1 is 0.50 ml/g.min1/2. The results illustrate that the method for measuring residual gas content and the fusion index of the K1 value during the effect test of regional prevention measures is convenient and effective for advanced regional verification of adjacent coal seams, which can also provide a reference and guiding significance for the regional verification of adjacent coal seams of gas outbursts under similar conditions.
Velocity changes after the 2021 MS 6.4 Yangbi earthquake based on passive image interferometry
Authors: Zhou Cong , Fu Lei , Shi Kexu , Zeng Xiangzhi , Zhang Pei 
Published: January 2023

An MS 6.4 earthquake occurred in Yangbi, Yunan Province, China, on 21 May 2021. The epicenter was on the blind branch fault in the west of the Weixi–Qiaohou–Weishan fault, but no surface rupture was obvious. In the present study, the continuous vertical component of waveforms that were recorded in six nearby permanent stations was collected and the noise cross-correlation and autocorrelation techniques were utilized to investigate velocity changes that were induced by the Yangbi Earthquake. Velocity changes based on the single-station autocorrelation method reveal mainly coseismic declines, and a maximum of .09% was recorded in the EYA station. Results from the cross-correlation technique show both positive and negative velocity changes, and these lasted for approximately 3 months. The volumetric strain that was generated by the Yangbi Earthquake at a depth of 5 km exhibits an obvious four-quadrant distribution. Station pairs in the dilatation region (e.g., EYA–HEQ) mainly display a decrease in velocity, whereas those in the contraction region (e.g., BAS–TUS, TUS–YUL, and LUS–TUS) show an increase in velocity. Based on the depth sensitivity of scattered waves, velocity changes that were obtained using the noise cross-correlation involve the highest weight coefficients near the related two stations. Regarding stations of one station pair in different stress loading regions, the static stress of the station that is nearest to the epicenter exerted a greater impact on the velocity change. The observed velocity changes are likely attributed to a combination of near-surface physical damage and static stress changes. The validation of clock errors with magnitudes of seconds that were obtained using the noise cross-correlation and effects of these errors on measured velocity changes are also discussed.