bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction
Authors: Ni Zhizhan , Cao Yuepeng , Liu Liming , Huang Chenshen , Xie Huahao , Zhou Jinzhe , Ge Bujun , Huang Qi 
Published: January 2023

Abstract
Background
Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify this in the angle of circulating tumor cells (CTCs).

Methods
A multicenter study was performed from March 2018 to January 2021. Thirty-two colorectal cancer patients with obstruction were selected, of which 21 patients were performed SEMS as a BTS while 11 patients were performed emergency surgery. Bloods samples were collected in two groups of patients for further detecting CTCs. In the SEMS group, the samples were collected before and after stent insert and after radical surgery performed. In the ES group, the samples were collected before stent insert and after emergency surgery performed.

Results
The number of CTCs did not show statistically significant differences before and after stent placement (34.90 vs 38.33, p=0.90), neither between the SEMS group and ES group in initial CTC levels (34.90 vs 58.09, p=0.394). No significant differences (38.33 vs 58.09, p=0.632) were observed after stent insert in the SMES group and the initial CTC levels in the ES group. Moreover, no major differences (24.17 vs 42.27, p=0.225) were observed after radical operation performed in both groups.

Conclusion
The treatment of SEMS does not cause an increase in the number of CTC after stent insertion. Furthermore, there are may be other factors besides CTC to cause these poorer oncologic outcomes after SEMS placement.
Endoplasmic reticulum stress mediates the myeloid-derived immune suppression associated with cancer and infectious disease
Authors: Lou Xiaoli , Gao Deyong , Yang Liyuan , Wang Yue , Hou Yanqiang 
Published: January 2023

AbstractMyeloid-derived suppressor cells (MDSCs), which are immature heterogeneous bone marrow cells, have been described as potent immune regulators in human and murine cancer models. The distribution of MDSCs varies across organs and is divided into three subpopulations: granulocytic MDSCs or polymorphonuclear MDSCs (G-MDSCs or PMN-MDSCs), monocytic MDSCs (M-MDSCs), as well as a recently identified early precursor MDSC (eMDSCs) in humans. Activated MDSCs induce the inactivation of NK cells, CD4+, and CD8+ T cells through a variety of mechanisms, thus promoting the formation of tumor immunosuppressive microenvironment. ER stress plays an important protecting role in the survival of MDSC, which aggravates the immunosuppression in tumors. In addition, ferroptosis can promote an anti-tumor immune response by reversing the immunosuppressive microenvironment. This review summarizes immune suppression by MDSCs with a focus on the role of endoplasmic reticulum stress-mediated immune suppression in cancer and infectious disease, in particular leprosy and tuberculosis.
Student-content interactions: Exploring behavioural engagement with self-regulated inquiry-based online learning modules
Authors: Al Mamun Md Abdullah , Lawrie Gwendolyn 
Published: January 2023

AbstractTechnological innovations and changing learning environments are influencing student engagement more than ever before. These changing learning environments are affecting the constructs of student behavioural engagement in the online environment and require scrutiny to determine how to facilitate better student learning outcomes. Specifically, recent literature is lacking in providing insights into how students engage and interact with online content in the self-regulated environment, considering the absence of direct teacher support. This paper investigates how instructional design, informed by the factors relating to behavioural engagement, can influence the student-content interaction process within the fabric of inquiry-based learning activities. Two online learning modules on introductory science topics were developed to facilitate students’ independent study in an asynchronous online environment. The study revealed that students showed a high commitment to engaging and completing the tasks that required less manipulative and pro-active effort during the learning process. The findings also revealed that instructional guidance significantly improved the behavioural engagement for student groups with prior learning experience in science simulations and technology skills. This study highlights several issues concerning student engagement in a self-regulated online learning environment and offers possible suggestions for improvement. The findings might contribute to informing the practice of teachers and educators in developing online science modules applicable to inquiry-based learning.
Quantifying the daily intake of water from morning and spot urine samples; retrospective analysis of a clinical trial in volunteers
Authors: Hahn Robert G. 
Published: January 2023

Abstract
Background
The hydration status can be indicated by biomarkers in the urine. However, the sensitivity and specificity of single measurements of biomarkers in morning urine and spot urine samples to quantify previous and current daily water ingestion is unclear.

Methods
The water content of food and liquid consumed by 20 volunteers (mean age 42 years) was calculated daily for two weeks. The volunteers increased their consumption of water by approximately 30% during the second week. They measured their excreted urine volume and sampled the morning urine and 24-h collections of urine for analysis of osmolality and creatinine during the first four days of both weeks (N = 157). The same biomarkers of hydration were measured in spot samples taken at every voiding on the other days (N = 762). Receiver operating characteristic (ROC) curves were used to study the ability of pre-specified ranges of biomarkers to quantify the water intake.

Results
The biomarkers in the morning urine obtained during normal fluid intake quantified the water consumption with an average area under the ROC curve (AUC) of 0.72 for osmolality and 0.66 for creatinine. Spot urine yielded an AUC of 0.74 for osmolality and 0.70 for creatinine. The AUCs obtained for days of increased fluid intake were approximately 10% lower. Large intakes (3–4 L daily) were identified with a sensitivity of 50–80% and low intakes (< 1.5–2 L) with a sensitivity of 20–50%, while false positives occurred in approximately 10%.

Conclusion
Biomarkers in morning urine and spot urine samples distinguished between large and small daily water intakes. Osmolality was slightly superior to creatinine. The indications were less useful during days of increased fluid intake.
The effect of vitamin D supplementation on body composition in nursing mothers with overweight or obesity: a randomized double-blind placebo-controlled clinical trial
Authors: Gerveieeha Zohre , Siassi Fereydoun , Qorbani Mostafa , Menbar Rezgar Shahi , Ahmadi Mohammad Hossein , Sotoudeh Gity 
Published: January 2023

AbstractBackgroundThis study aimed to evaluate the effect of vitamin D3 supplementation on body composition and anthropometric measures of nursing mothers.MethodsIn a double-blind, randomized clinical trial, 90 nursing mothers with overweight or obesity were randomized into three groups for 12 weeks: two groups of vitamin D3 supplementation (2000 IU/d (VD1),n = 32 and 4000 IU/d (VD2),n = 29) and placebo (PL) group (n = 29). The information on body composition was obtained using the body impedance analysis (BIA) method. Serum 25-Hydroxy vitamin D (25(OH) D), Intact Parathyroid Hormone (iPTH), calcium, and phosphorus were measured before and after the intervention. Data were analyzed based on the intention-to-treat (ITT) method. Two-way repeated measure ANOVA (mixed ANOVA) was applied to assess whether the mean changes in the results from baseline to 12 weeks differ in the three groups.ResultsThere was a significant increase in the serum 25(OH) D concentration in the VD2 group compared to VD1 and PL groups (mean change (MC), 12.3 ng/ml; 95% CI, 9.4/15.0,p-value < 0.001). In addition, fat mass (MC, − 4.3 kg; 95% CI, − 7.0/− 1.1,p-value < 0.007), fat mass index (MC, − 1.6; 95% CI, − 2.6/− 0.5,p-value < 0.006) and body fat percentage (MC, − 8.1; 95% CI, − 12.0/− 4.2,p-value < 0.007) reduced in VD2 group as compared with VD1 and PL groups.ConclusionThe intake of 4000 IU/d vitamins D3 supplementation would elevate circulating 25(OH) D concentrations in nursing mothers with overweight or obesity and improve some indices of body composition.Trial registrationIranian Registry of Clinical Trials (http://www.irct.ir: IRCT20140413017254N6) registered on 11-04-2018.Graphical AbstractThe graphical abstract of this clinical trial, is a figure that explains the final results of the manuscript in a clear and attractive way
Withdrawal of antihypertensive medication in young to middle-aged adults: a prospective, single-group, intervention study
Authors: Lee Hae-Young , Lee Kyoung Suk 
Published: January 2023

Abstract
Background
Although antihypertensive drug therapy is commonly believed to be a life-long therapy, several recent guidelines have suggested that antihypertensive medications can be gradually reduced or discontinued for some patients whose blood pressure (BP) is well-controlled for an extended period. Thus, this pilot study aimed to describe the success rate of antihypertensive drug discontinuation over 6 months among young and middle-aged patients with hypertension.

Methods
This was a prospective, single-group, intervention study. Patients were eligible for inclusion if their cardiologist judged them to be appropriate candidates for this study, their BP had been controlled both in the office (< 140/90 mmHg) and 24-h ambulatory BP monitoring (< 135/85 mmHg) for at least 6 months with a single tablet dose of antihypertensive medication. A total of 16 patients withdrew their antihypertensive medications at baseline after they received the education, and were followed up over 6 months. After the follow-ups, six patients participated in the in-depth interview.

Results
The likelihood of remaining normotensive at 30, 90, 180, and 195 days was 1.00, 0.85, 0.51, and 0.28, respectively. There were also no significant differences in baseline characteristics and self-care activities over time between normotensive (n = 8) and hypertensive groups (n = 8). In the interview, most patients expressed ambivalent feelings toward stopping medications. Psychological distress (e.g., anxiety) was the primary reason for withdrawal from this study although the patients’ BP was under control.

Conclusions
We found that only a limited portion of antihypertensive patients could stop their medication successively over 6 months. Although we could not identify factors associated with success in maintaining BP over 6 months, we believe that careful selection of eligible patients may increase success in stopping antihypertensive medications. Also, continuous emotional support might be essential in maintaining patients’ off-medication.
A cluster positioning architecture and relative positioning algorithm based on pigeon flock bionics
Authors: Deng Zhongliang , Qi Hang , Wu Chengfeng , Hu Enwen , Wang Runmin 
Published: January 2023

AbstractUnmanned clusters can realize collaborative work, flexible configuration, and efficient operation, which has become an important development trend of unmanned platforms. Cluster positioning is important for ensuring the normal operation of unmanned clusters. The existing solutions have some problems such as requiring external system assistance, high system complexity, poor architecture scalability, and accumulation of positioning errors over time. Without the aid of the information outside the cluster, we plan to construct the relative position relationship with north alignment to adopt formation control and achieve robust cluster relative positioning. Based on the idea of bionics, this paper proposes a cluster robust hierarchical positioning architecture by analyzing the autonomous behavior of pigeon flocks. We divide the clusters into follower clusters, core clusters, and leader nodes, which can realize flexible networking and cluster expansion. Aiming at the core cluster that is the most critical to relative positioning in the architecture, we propose a cluster relative positioning algorithm based on spatiotemporal correlation information. With the design idea of low cost and large-scale application, the algorithm uses intra-cluster ranging and the inertial navigation motion vector to construct the positioning equation and solves it through the Multidimensional Scaling (MDS) and Multiple Objective Particle Swarm Optimization (MOPSO) algorithms. The cluster formation is abstracted as a mixed direction-distance graph and the graph rigidity theory is used to analyze localizability conditions of the algorithm. We designed the cluster positioning simulation software and conducted localizability tests and positioning accuracy tests in different scenarios. Compared with the relative positioning algorithm based on Extended Kalman Filter (EKF), the algorithm proposed in this paper has more relaxed positioning conditions and can adapt to a variety of scenarios. It also has higher relative positioning accuracy, and the error does not accumulate over time.
Pengembangan Special E-Class Pada Learning Management System Untuk Mahasiswa Tunarungu
Authors: Luthpi Luthpi , Rahmat Dadan , Yudianto Arif 
Published: January 2023

penelitian ini bertujuan untuk mengembangkan teknologi bantu sebagai layanan pembelajaran bagi mahasiswa berkebutuhan khusus, dengan mengembangkan system pembelajaran online. System pembelajaran online disini mengakomodir kelas khusus bagi mahasiswa berkebutuhan khusus yang dinamakan special e-class. Dalam kelas khusus tersebut dikembangkan juga matakuliah yang memiliki konten digital yang dibuat khusus bagi penyandang disabilitas. Metode yang digunakan pada penelitian ini adalah penelitian dan pengembangan atau biasa disebut Research and Development (R and D) . R and D adalah metode penelitian yang digunakan untuk menghasilkan produk tertentu, dan menguji keefektifan produk tersebut. Media pembelajaran layak untuk digunakan jika hasil validasi para ahli dan pengguna mencapai 26%≤skor≤50% skala nila 2 dalam kriteria minimal “cukup layak”. Dari perhitungan tersebut didapatkan penilaian dari ahli materi 93,75% untuk materi matakuliah jaringan komputer dan penilaian dari ahli media 84,6% untuk pengembangan video pembelajaran sementara para pengguna memberikan nilai sebesar 88,6%. Dari hasil tersebut menunjukkan bahwa produk yang dikembangkan layak dijadikan media pembelajaran bagi mahasiswa trunarungu
Strategi Pembelajaran untuk Meningkatkan Motivasi Belajar Siswa SMP
Authors: Sheilawati Azzahra Bunga , Hasanah Enung 
Published: January 2023

Strategi pembelajaran merupakan suatu kegiatan pembelajaran yang harus dikerjakan guru dengan siswa agar tujuan pembelajaran dapat mendukung dalam pelaksanaan strategi pembelajaran dicapai secara efektif dan efisien. Menumbuhkan motivasi belajar terhadap siswa SMP merupakan salah satu teknik dalam mengembangkan kemauan serta kemampuan belajar siswa karena di umur awal remaja ini yang begitu masih labil terhadap segala sesuatu maka dari itu sebagai guru sangat berkepentingan dengan permasalahan ini. Salah satu cara yang logis untuk memotivasi siswa dalam pembelajaran adalah mengaitkan pengalaman belajar dengan motivasi siswa. Sehingga sebagai guru atau calon guru sebisa mungkin kita harus selalu berupaya untuk dapat meningkatkan motivasi belajar terutama bagi siswa yang mengalami kesulitan dalam belajar.
REVISÃO DE PLANO DIRETOR: ADERÊNCIA DE UMA PROPOSTA URBANÍSTICO-AMBIENTAL
Authors: Araújo Ronaldo De Sousa 
Published: January 2023

Este artigo apresenta um estudo de modificações decorrentes da revisão do Plano Diretor de Campos dos Goytacazes - RJ, especialmente nos seguintes aspectos: macro sistema viário, áreas verdes e uso do solo. O objetivo da pesquisa foi verificar e avaliar a aderência de uma proposta nas modificações no planejamento urbanístico ocorridas na área urbana de Campos dos Goytacazes com a aprovação do Plano Diretor e Lei de Uso e Ocupação do Solo de 2020. Para o desenvolvimento do trabalho foram realizadas pesquisas bibliográficas e documentais, comparação dos mapas de uso do solo de 2008 e 2020 com o mapa de propostas de Araújo de 2018. Também foram utilizadas imagens de satélite do Google Earth Pro como suporte para as análises. A pesquisa disponibiliza imagens dos mapas e recortes com áreas modificadas pelo planejamento, assim como as respectivas análises qualitativas. Verificou-se que o mapa de propostas estudado representou significativa mudança no planejamento urbanístico-ambiental de Campos dos Goytacazes, propiciando uma nova configuração do espaço. Conclui-se que no processo de revisão do planejamento urbanístico de Campos ocorreram várias modificações qualitativas que poderão influenciar positivamente no desenvolvimento da cidade, e que houve significativa aderência de proposta de Araújo de 2018 no novo plano diretor.
Investimentos públicos e o planejamento econômico-territorial: o fracasso dos planos e a insuficiência das redes técnicas e de logísticas no Rio de Janeiro
Authors: Oliveira Floriano José Godinho de 
Published: January 2023

Uma nova economia se desenvolve no interior do estado e no espaço metropolitano do Rio de Janeiro. Contudo, o crescimento e recuperação econômica do estado depende dos fluxos de capitais - em suas diferentes fases, como capital monetário, como capital produtivo e como capital mercadorias (MARX, 1984) - que dependem das condições de circulação e das redes técnicas capazes de garantir os fluxos. Afinal, como assevera David Harvey (2010), capital é fluxo. Isto exige planejamento e, sobretudo, investimentos logisticos e territoriais,o que não é feito pelo Estado no Rio de Janeiro[1]. E sobre esse tema que trataremos nesse artigo. Para tanto, precisamos, antes, situar esta questão no marco teórico do processo de reestruturação produtiva da economia industrial, no qual a economia fluminense se insere.[1] Não faltam planos e projetos, como o PELC 40 (sobre transportes de diferentes modais); Plano Estratégico Ferroviário, de 2021; PDUI (Plano de Desenvolvimento Urbano Integrado), de 2016, etc. Planos elaborados por empresas de consultorias que não são aplicados e tampouco recebem os investimentos indicados.
Marco legal do direito à moradia no Brasil / Legal framework of the right to housing in Brazil
Authors: Melo Adalgisa Costa , Lima Francisco Meton Marques de 
Published: January 2023

ResumoO presente trabalho pretende descrever o marco legal do direito à moradia, através da apresentação do caminho percorrido desde a Declaração Universal de Direitos Humanos até sua positivação na Constituição Federal brasileira de 1988 e o seu marco legal a partir de então. Assim sendo, além do aprofundamento em torno do seu percurso legal, foi dedicada especial atenção ao debate envolvendo sua autonomia em relação ao direito de propriedade, a segurança jurídica da posse, bem como, os indicadores de direito à moradia no Brasil. Para isto, foi desenvolvido com base no método hipotético- dedutivo, numa abordagem qualitativa e através de uma pesquisa descritiva, utilizando-se das técnicas da pesquisa bibliográfica e documental, com fundamento na análise temática de conteúdos. Isto posto, constatou-se que o Brasil é signatário de copiosos tratados internacionais de direitos humanos e conta, também, com uma vultosa legislação que visa assegurar a sua concretização, contudo, ainda persiste a necessidade de atualização da legislação, através da criação de instrumentos jurídicos aptos a protegerem o direito de morar, de maneira, não necessariamente, vinculada ao direito de propriedade. Tudo isso vai de encontro aos dados oficiais, que demonstram que milhões de brasileiros são socialmente excluídos do acesso a esse direito fundamental.Palavras-chave: Moradia. Posse. Propriedade. Função social da propriedade. Indicadores. AbstractThe present work intends to describe the legal framework of the right to housing, through the presentation of the path taken from the Universal Declaration of Human Rights to its positivity in the Brazilian Federal Constitution of 1988 and its legal framework from then on. Therefore, in addition to deepening around its legal path, special attention was paid to the debate involving its autonomy in relation to property rights, legal security of tenure, as well as indicators of the right to housing in Brazil. For this, it was developed based on the hypothetical-deductive method, in a qualitative approach and through a descriptive research, using the techniques of bibliographic and documentary research, based on thematic content analysis. That said, it was found that Brazil is a signatory to copious international human rights treaties and also has extensive legislation that aims to ensure its implementation, however, there is still a need to update the legislation, through the creation of instruments legal entities capable of protecting the right to live, in a way that is not necessarily linked to the right to property. All of this goes against official data, which shows that millions of Brazilians live with social exclusion caused by the absence of a roof to live in a dignified way.Keywords: Home. Possession. Property. Social function of property. Indicators.
Políticas públicas habitacionais brasileiras e a capacidade prestacional do Poder Público / Brazilian Housing Public Policies And The Prestational Capacity Of Public Power
Authors: Melo Adalgisa Costa , Lima Francisco Meton Marques de 
Published: January 2023

Resumo A presente investigação busca descrever as principais políticas públicas habitacionais brasileiras pós Constituição Federal de 1988, com ênfase para o Estado do Piauí. Para isto, alicerçada no método hipotético-dedutivo, optou-se pela pesquisa descritiva, desenvolvida com base na análise temática de conteúdos. Desta forma, abordou inicialmente, a descentralização da política habitacional e o papel dos entes federativos, num ambiente marcado pela redemocratização do país. Em seguida, voltou-se para a Política Nacional de Habitação desenvolvida a partir de então, aprofundando-se na sua evolução desde a criação do Sistema Nacional de Habitação de Interesse Social até a criação do Programa Minha Casa Minha Vida. Dedicou-se, ainda, aos fundos que abastecem a Habitação de Interesse Social e aos fundos de financiamento da habitação social no Programa Minha Casa Minha Vida, finalizando com uma reflexão sobre a atual política de acesso à moradia, que vem sendo planejada e construída de maneira mercantilizada.Palavras-chave: Moradia. Políticas Públicas Habitacionais. Sistema Nacional de Habitação de Interesse Social. Programa Minha Casa Minha Vida. Mercantilização da Moradia. Abstract The present investigation seeks to describe the main Brazilian public housing policies after the 1988 Federal Constitution, with an emphasis on the State of Piauí. For this, based on the hypothetical- deductive method, we opted for descriptive research, developed based on thematic content analysis. In this way, it initially addressed the decentralization of housing policy and the role of federative entities, in an environment marked by the redemocratization of the country. Then, it turned to the National Housing Policy developed since then, deepening its evolution from the creation of the National Housing System of Social Interest to the creation of the Minha Casa Minha Vida Program. He also dedicated himself to the funds that supply Social Interest Housing and the social housing financing funds in the Minha Casa Minha Vida Program, ending with a reflection on the current policy of access to housing, which has been planned and built in accordance with commercialized way.Keywords: Home. Public Housing Policies. National Social Interest Housing System. Minha Casa Minha Vida Program. Housing Mercantilization.