bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Target Information for Preparing Initial Motor Command of Target Force Production Task
Authors: Hiraoka Koichi , Hashimoto Keita , Fukuchi Takumi 
Published: August 2023

The present study examined how humans use the target information provided immediately before the onset of motor output to prepare the initial motor command in the target force production task. Twenty healthy individuals participated in this study. A target cursor indicating the target force, and a force cursor indicating the force produced with index finger flexion were presented, and participants produced force in response to the appearance of the force cursor so that it moved toward the target cursor as fast as possible. The rate of force development in a time window of 0–100 ms after the onset of force development, representing the intensity of the initial motor command without online feedback adjustment, was measured. The present findings support the hypotheses that humans use the target information provided immediately before the onset of motor output to prepare the initial motor command, and they simultaneously prepare the initial motor command for the intermediate of multiple potential targets using the information of targets provided in previous trials. Another hypothesis, that humans use the information of the target or motor process of the trial immediately before the current trial to prepare the initial motor command, was not supported.
Complete genome sequence of
Streptomyces
sp. strain VNUA24, a potential antifungal bacterium isolated from soil
Authors: Dang Tam Thi Thanh , Dinh Son Truong , Nguyen Thu Thi , Nguyen Hai Thanh , Nguyen Canh Xuan 
Published: August 2023

ABSTRACT

Streptomyces
species are important resources for secondary metabolites, including antimicrobial compounds. The
Streptomyces
sp. strain VNUA24 was isolated from a soil sample in Vietnam. The strain was identified as having antifungal activity against numerous fungal pathogens. Whole-genome sequencing was done to explore the biocontrol capability of this strain.
Saturating growth rate against phosphorus concentration explained by macromolecular allocation
Authors: Armin Gabrielle , Kim Jongsun , Inomura Keisuke 
Published: August 2023

ABSTRACT
The saturating relationship between phytoplankton growth rate and environmental nutrient concentration has been widely observed, yet the mechanisms behind the relationship remain elusive. Here, we use a mechanistic model of phytoplankton and show that the saturating relationship between growth rate and phosphorous concentration can be interpreted by intracellular macromolecular allocation. At low nutrient levels, the diffusive nutrient transport linearly increases with the phosphorous concentration, while the internal phosphorous requirement increases with the growth rate, leading to a non-linear increase in the growth rate with phosphorous. This increased phosphorous requirement is due to the increased allocation to biosynthetic and photosynthetic molecules. The allocation to these molecules reaches a maximum at high-phosphorous concentration, and the growth rate no longer increases despite the rise in phosphorous concentration. The produced growth rate and phosphorous relationships are consistent with the data of phytoplankton across taxa. Our study suggests that the key control of phytoplankton growth is internal, and nutrient uptake is only a single step in the overall process.

IMPORTANCE
The Monod equation has been used to represent the relationship between growth rate and the environmental nutrient concentration under the limitation of this respective nutrient. This model often serves as a means to connect microorganisms to their environment, specifically in ecosystem and global models. Here, we use a simple model of a marine microorganism cell to illustrate the model’s ability to capture the same relationship as Monod, while highlighting the additional physiological details our model provides. In this study, we focus on the relationship between growth rate and phosphorus concentration and find that RNA allocation largely contributes to the commonly observed trend. This work emphasizes the potential role our model could play in connecting microorganisms to the surrounding environment while using realistic physiological representations.
Fault Striae Analysis and Paleostress Reconstruction of the Northern Tectonic Province (Egyptian Nubian Shield): Insights into the Brittle Deformation History of the Northern East African Orogen
Authors: Hamimi Z. , El Sundoly H. , Delvaux D. , Waheeb A. , Hagag W. , Younis M. H. 
Published: August 2023

Abstract
The Egyptian Nubian Shield (ENS), the northwestern continuation of the East African Orogen (EAO), comprises a variety of three lithologically and structurally different tectonic provinces—southern compressional-, central transpressional/wrench-, and northern extensional- provinces. The extensional tectonic province (ETP) extends from Qena‒Safaga shear belt up to the northern tip of the ENS. Several lines of evidence indicate extensional regime in the ETP, such as mantle delamination-induced post-orogenic magmatism and bimodal Dokhan Volcanics, together with the pervasive E‒W dyke swarms and the E‒W (to ENE‒WSW) oriented extensional fractures. The present work is devoted to carry out the fault striae analysis and paleostress reconstruction of the northern tectonic province (ENS) in attempt to add more contribution to the brittle deformation history of the northern EAO. Field measurements collected from six areas (I‒VI) have been processed using Win-Tensor Software. Analysis of fault-slip data revealed four paleostress tensor stages (groups or regimes) that prevailed in the ENS. The stress states and related tectonic regimes are characterized by the stress regime index R' and the horizontal stress axes as follows: 1st stage: transpression (R' = 1.91), E‒W compression (SHmax = N090°‒270° E); 2nd stage: transtension (R' = 1.16), N‒S compression (SHmax = 174°‒354° E); 3rd stage: transpression (R' = 1.81), NE‒SW compression (SHmax = N053°‒233° E); 4th stage: extension (R' = 0.31), E‒W extension (Shmin = N074°‒254° E). The 1st stage can be related to the oblique convergence between E and W Gondwanalands. The 2nd stage was probably concurrent with the N- to NNW-ward migration of the Central Eastern Desert syn-collisional delamination (triggering orogen-parallel extensional collapse) to the North Eastern Desert post-collisional delamination. The 3rd stage was controlled by the generally N‒S shortening which affected the northern and central ENS, post-dating the formation of volcanosedimentary Hammamat Basins. The 4th stage is akin to retreat of the Cadomian arc and the Red Sea rifting.
Inclusion of abortion-related care in national health benefit packages: results from a WHO global survey
Authors: Footman Katy , Goel Kratu , Rehnström Loi Ulrika , Mirelman Andrew J , Govender Veloshnee , Ganatra Bela 
Published: August 2023

IntroductionService inclusion in a country’s health benefit package (HBP) is an important milestone towards universal health coverage. This study aimed to explore HBP inclusion of abortion interventions globally.MethodsSecondary analysis of the WHO HBP survey, in which officially nominated survey focal points were asked which interventions were included within the HBP of their country or area’s largest government health financing scheme. Abortion inclusion was compared by region, income, legal status of abortion and HBP design process variables. Abortion inclusion was compared with other sexual and reproductive health (SRH) services.ResultsBelow half (45%) reported that abortion is included, but treatment of complications from unsafe abortion was more commonly included (63%). Fewer fully included essential abortion medications (22% mifepristone, 42% misoprostol). Abortion was less commonly included than any other SRH service in the survey. Unlike most SRH services, higher cost, higher technology care to treat complications of unsafe abortion was more commonly included than the relatively lower cost, lower technology service of induced abortion. Higher-income contexts and less restrictive legal environments had higher abortion inclusion. Some contexts had additional restrictions, with abortion inclusion dependent on the patient’s reason for seeking care.ConclusionThis global survey finds that abortion services and medications are often not included within HBPs, while treatment of complications from unsafe abortion is more commonly included. There are opportunities to improve HBP abortion inclusion across different legal contexts, which can improve health outcomes and reduce the need for higher cost treatment of complications from unsafe abortion.
Role of lipoprotein(a) concentrations in bioprosthetic aortic valve degeneration
Authors: Farina Juan M , Chao Chieh-Ju , Pereyra Milagros , Roarke Michael , Said Ebram F , Barry Timothy , Alsidawi Said , Sell-Dottin Kristen , Sweeney John P , Fortuin David F , Ayoub Chadi , Lester Steven J , Oh Jae K , Arsanjani Reza , Marcotte Francois 
Published: August 2023

ObjectivesLipoprotein(a) (Lp(a)) is associated with an increased incidence of native aortic stenosis, which shares similar pathological mechanisms with bioprosthetic aortic valve (bAV) degeneration. However, evidence regarding the role of Lp(a) concentrations in bAV degeneration is lacking. This study aims to evaluate the association between Lp(a) concentrations and bAV degeneration.MethodsIn this retrospective multicentre study, patients who underwent a bAV replacement between 1 January 2010 and 31 December 2020 and had a Lp(a) measurement were included. Echocardiography follow-up was performed to determine the presence of bioprosthetic valve degeneration, which was defined as an increase >10 mm Hg in mean gradient from baseline with concomitant decrease in effective orifice area and Doppler Velocity Index, or new moderate/severe prosthetic regurgitation. Levels of Lp(a) were compared between patients with and without degeneration and Cox regression analysis was performed to investigate the association between Lp(a) levels and bioprosthetic valve degeneration.ResultsIn total, 210 cases were included (mean age 74.1±9.4 years, 72.4% males). Median time between baseline and follow-up echocardiography was 4.4 (IQR 3.7) years. Bioprostheses degeneration was observed in 33 (15.7%) patients at follow-up. Median serum levels of Lp(a) were significantly higher in patients affected by degeneration versus non-affected cases: 50.0 (IQR 72.0) vs 15.6 (IQR 48.6) mg/dL, p=0.002. In the regression analysis, high Lp(a) levels (≥30 mg/dL) were associated with degeneration both in a univariable analysis (HR 3.6, 95% CI 1.7 to 7.6, p=0.001) and multivariable analysis adjusted by other risk factors for bioprostheses degeneration (HR 4.4, 95% CI 1.9 to 10.4, p=0.001).ConclusionsHigh serum Lp(a) is associated with bAV degeneration. Prospective studies are needed to confirm these findings and to investigate whether lowering Lp(a) levels could slow bioprostheses degradation.
Comprehensive characterisation of acinar cystic transformation of the pancreas: a systematic review
Authors: Mattiolo Paola , Wang Huamin , Basturk Olca , Brosens Lodewijk A A , Hong Seung-Mo , Adsay Volkan , Scarpa Aldo , Luchini Claudio 
Published: August 2023

AimsAcinar cystic transformation (ACT) of the pancreas is a rare pancreatic cystic lesion. Owing to its rarity, comprehensive histomolecular characterisation of this entity is still lacking. We aim to perform a systematic review on this controversial entity.MethodsWe searched PubMed, SCOPUS and Embase through May 2023 to identify all studies on ACTs. Clinicopathological, immunohistochemical (IHC) and molecular data have been extracted and analysed.ResultsOverall, there were 121 cases of ACTs in the literature. ACT had a female predominance (65.3% of patients), and a mean size of 4.8 cm. ACT was more often unifocal (71.9%) and multiloculate (61.2%). Histologically, the cysts were lined by an acinar epithelium, sometimes harbouring ductal-like areas (18.2%). In five cases (4.1%), an intralesional pancreatic intraepithelial neoplasia (PanIN) was reported. Preoperative diagnosis is challenging. After surgical resection, all patients were alive and disease free during follow-up except one patient who developed a second ACT after resection. By IHC, all lesions were positive for acinar markers; cytokeratin 7 and 8/18/19 were usually positive, and Ki-67 was invariably ≤3%. At the molecular level, three cases demonstrated genetic alterations: one showed multiple chromosomal gains, and other two harboured somatic mutations ofKRASandSMOgenes (one mutation per case).ConclusionsGlobally considered, our findings demonstrated that ACT is a benign entity, without the need of surgical resection with the exception of symptomatic lesions. The rare occurrence of intracystic PanINs and driver mutations suggest considering follow-up if a preoperative diagnosis of ACT can be made.
Where ice gave way to fire: deglacial volcanic activity at the edge of the Coast Mountains in Milbanke Sound, BC
Authors: Hamilton Tark S. , Enkin Randolph J. , Li Zhen , Bednarski Jan M. , Stacey Cooper D. , McGann Mary L. , Jensen Britta J.L. 
Published: August 2023

Kitasu Hill and MacGregor Cone formed along the Principe Laredo Fault on British Columbia’s central coast as the Wisconsinan ice sheet withdrew from the Coast Mountains. These small-volume Milbanke Sound Volcanoes (MSV) provide remarkable evidence for the intimate relationship between volcanic and glacial facies. The lavas are within-plate, differentiated (low MgO < 7%) Ocean Island Basalts, hawaiites, and mugearites that formed from ∼1% decompression melting of asthenosphere with residual garnet. Kitasu Hill, on glaciated bedrock, formed between 18 and 15 cal ka BP. Dipping, poorly stratified, admixed hyaloclastite, and glacial diamicton with large plutonic clasts and pillow breccia comprise its basal tuya platform (0–43 masl). Subaerial nested cinder cones, with smaller capping lava flows, sit atop the tuya. New marine samples show McGregor Cone formed subaerially but now sits submerged at 43–200 mbsl on an eroded moraine at the mouth of Finlayson Channel. Seismic data and cores reveal glaciomarine sediments draping the cone’s lower slopes and show beach terraces. Cores contain glaciomarine diamictons, ice-rafted debris, delicate glassy air fall tephra, and shallow, sublittoral, and deeper benthic foraminifera. Dates of 14.1–11.2 cal ka BP show volcanism spanned ∼2000 years during floating ice shelf conditions. The MSV have similar proximal positions to the retreating ice sheet, display mixed volcano-glacial facies, and experienced similar unloading stresses during deglaciation. The MSV may represent deglacially triggered volcanism. The dates, geomorphic and geological evidence, constrain a local relative sea level curve for Milbanke Sound and show how ice gave way to fire.
Regular black holes from analytic $$f(F^2)$$
Authors: Li Zhi-Chao , Lü H. 
Published: August 2023

AbstractWe construct regular black holes and horizonless spacetimes that are geodesically complete and satisfy the dominant energy condition from Einstein-$$f(F^2)$$

f
(

F
2

)

gravities with several classes of analytic $$f(F^2)$$

f
(

F
2

)

functions that can be viewed as perturbations to Maxwell’s theory in weak field limit. We establish that regular black holes with special static metric ($$g_{tt} g_{rr}=-1$$

g

tt

g

rr

=
-
1

) violate the strong energy condition and such a regular black hole with Minkowski core violates the null energy condition. We develop a formalism to perform electromagnetic duality transformations in $$f(F^2)$$

f
(

F
2

)

. We obtain two new explicit examples where the duality is a symmetry. We study the properties of the corresponding dyonic black holes. We study the geodesic motions of a particular class of solutions that we call horizonless or black hole repulsons.
Predictions for exclusive $$\varUpsilon $$ photoproduction in ultraperipheral $${\textrm{Pb}}+{\textrm{Pb}}$$ collisions at the LHC at next-to-leading order in perturbative QCD
Authors: Eskola Kari J. , Flett Christopher A. , Guzey Vadim , Löytäinen Topi , Paukkunen Hannu 
Published: August 2023

AbstractWe present predictions for the rapidity-differential cross sections of exclusive $$\varUpsilon $$
Υ
photoproduction in ultraperipheral collisions (UPCs) of lead ions at the Large Hadron Collider (LHC). We work in the framework of collinear factorization at next-to-leading order (NLO) in perturbative QCD, modeling the generalized parton distributions (GPDs) through the Shuvaev transform of nuclear parton distribution functions (nPDFs). Our direct NLO predictions depend significantly on nPDF uncertainties and on the choices of the factorization and renormalization scales, but to a much lesser degree on GPD modeling. To tame the scale dependence and to account for the fact that the NLO calculations generally underpredict the photoproduction measurements on protons, we also present alternative, data-driven predictions. In this approach the underlying photoproduction cross sections on lead are found by combining their nuclear modifications calculated at NLO with the measured photoproduction cross sections on protons. The data-driven strategy reduces the uncertainties associated with the scale choices, and essentially eliminates the effects of GPD modeling thereby leaving the cross sections sensitive mainly to the input nPDFs. Our estimates indicate that the process is measurable in $${\textrm{Pb}}+{\textrm{Pb}}$$

Pb
+
Pb

collisions at the LHC.
Efficient bright green phosphor for white light-emitting diode using in backlight application
Authors: Doan Duy Le , Hanh Nguyen Thi My , Thinh Nhan Hoang 
Published: August 2023

The (Ba,Ca)ScO2F:Bi3+,K+ phosphor with narrow emission band and green emission color peaking at 510 nm is demonstrated in the study. This phosphor is prepared using a solid-state reaction at high temperatures. Based on characterizing data, the increasing concentration of Ca2+ induces the shrinkage of the unit cell and the narrower spacing, leading to the increase in the photoluminescence of the phosphor. This also cause a red shift in the emitting range from 504 nm to 510 nm. The phosphor shows good absorption peaking at 415 nm, matching the excitation wavelength of the used nearultraviolet (UV) light emitting diode (LED) chip. When being applied in a white light‐emitting diodes (WLED) with 4,000 K, the phosphor could increase the luminous flux as its doping concentration increase. Besides, the WLED doping (Ba, Ca) ScO2F: Bi3+, K+ shows emission regions in blue, green, and red wavelength bands. The data from the study indicates that the phosphor is potential for developing the white-LED for backlight purposes.
A novel single switch controlled efficient coupled inductor-based DC-DC boost converter
Authors: Geshma Kumari Remala , Ezhilarasi Arivukkannu , Pasula Naresh 
Published: August 2023

Pollution is <span>one of the most hazard facing in the world. Day by day pollutions has been increased in the society due to population growth, industries, constructions, and transportation. As per the world health organization (WHO) survey, 45% of the air pollution is due to transportation because they lay on internal combustion engine (ICE) based engines. To avoid carbon footprints, green transportation should be encouraged for further generations. In recent days many electric vehicles (EV’s) are found in the market but facing some issues like battery blasts, storage limitations and lack of charging infrastructure. Out of these issues, mainly my focus is on developing a compact, efficient, simple, medium gain coupled inductor-based DC-DC boost converter is proposed which is helpful for fast charging system. In this paper, coupled inductor (CI) and switched coupled inductor (SCI) based converters are designed and analysed with mathematical approach. The outputs of both CI and SCI converters are verified and compared with simulation results and as well CI based converter is developed with hardware prototype and verified hardware and simulation results in terms of gain, elements and efficient.</span>
Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study
Authors: Hofmeyer Mark , Haas Garrie J. , Jordan Elizabeth , Cao Jinwen , Kransdorf Evan , Ewald Gregory A. , Morris Alanna A. , Owens Anjali , Lowes Brian , Stoller Douglas , Wilson Tang W.H. , Garg Sonia , Trachtenberg Barry H. , Shah Palak , Pamboukian Salpy V. , Sweitzer Nancy K. , Wheeler Matthew T. , Wilcox Jane E. , Katz Stuart , Pan Stephen , Jimenez Javier , Smart Frank , Wang Jessica , Gottlieb Stephen S. , Judge Daniel P. , Moore Charles K. , Huggins Gordon S. , Kinnamon Daniel D. , Ni Hanyu , Hershberger Ray E. ,   for the DCM Precision Medicine Study of the DCM Consortium
Published: August 2023

BACKGROUND:
Dilated cardiomyopathy (DCM) can lead to advanced disease, defined herein as necessitating a durable left ventricular assist device or a heart transplant (LVAD/HT). DCM is known to have a genetic basis, but the association of rare variant genetics with advanced DCM has not been studied.

METHODS:
We analyzed clinical and genetic sequence data from patients enrolled between 2016 and 2021 in the US multisite DCM Precision Medicine Study, which was a geographically diverse, multiracial, multiethnic cohort. Clinical evaluation included standardized patient interview and medical record query forms. DCM severity was classified into 3 groups: patients with advanced disease with LVAD/HT; patients with an implantable cardioverter defibrillator (ICD) only; or patients with no ICD or LVAD/HT. Rare variants in 36 DCM genes were classified as pathogenic or likely pathogenic or variants of uncertain significance. Confounding factors we considered included demographic characteristics, lifestyle factors, access to care, DCM duration, and comorbidities. Crude and adjusted associations between DCM severity and rare variant genetic findings were assessed using multinomial models with generalized logit link.

RESULTS:
Patients’ mean (SD) age was 51.9 (13.6) years; 42% were of African ancestry, 56% were of European ancestry, and 44% were female. Of 1198 patients, 347 had LVAD/HT, 511 had an ICD, and 340 had no LVAD/HT or ICD. The percentage of patients with pathogenic or likely pathogenic variants was 26.2%, 15.9%, and 15.0% for those with LVAD/HT, ICD only, or neither, respectively. After controlling for sociodemographic characteristics and comorbidities, patients with DCM with LVAD/HT were more likely than those without LVAD/HT or ICD to have DCM-related pathogenic or likely pathogenic rare variants (odds ratio, 2.3 [95% CI, 1.5–3.6]). The association did not differ by ancestry. Rare variant genetic findings were similar between patients with DCM with an ICD and those without LVAD/HT or ICD.

CONCLUSIONS:
Advanced DCM was associated with higher odds of rare variants in DCM genes adjudicated as pathogenic or likely pathogenic, compared with individuals with less severe DCM. This finding may help assess the risk of outcomes in management of patients with DCM and their at-risk family members.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03037632.