bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust fuzzy fault tolerant control for nonlinear active suspension systems via adaptive hybrid triggered scheme
Authors: Xie Zhengchao , You Wei , Wong Pak Kin , Li Wenfeng , Ma Xinbo , Zhao Jing 
Published: April 2023

SummaryThis article is concerned with the problem of robust fuzzy fault tolerant control for the nonlinear active suspension system via adaptive hybrid triggered scheme. To describe the system with high nonlinearity, a Takagi‐Sugeno fuzzy approach is applied by weighting a series of linear subsystems. During the design of the controller, the actuator failure is taken into consideration. To ease the network communication pressure, a novel adaptive hybrid triggered scheme is proposed for the suspension system. By applying a Bessel‐Legendre inequality and a Jensen's inequality together, the control algorithm can be derived in the form of linear matrix inequalities with less conservatism. Finally, compared with the existing sampled‐data control and adaptive event triggered control, numerical simulations are performed to demonstrate the effectiveness and superiority of the proposed controller.
Fishing Net‐Inspired Mutiscale Ionic Organohydrogels with Outstanding Mechanical Robustness for Flexible Electronic Devices
Authors: Zheng Bohui , Zhou Hongwei , Wang Zhao , Gao Yang , Zhao Guoxu , Zhang Hongli , Jin Xilang , Liu Hanbin , Qin Zhihan , Chen Weixing , Ma Aijie , Zhao Weifeng , Wu Yuanpeng 
Published: April 2023

AbstractMechanically robust and electrically conductive organohydrogels/hydrogels are increasingly required in flexible electronic devices, but it remains a challenge to achieve organohydrogels/hydrogels with integrated high performances. Herein, inspired by the geometric deformability and robustness of fishing nets, multiscale ionic organohydrogels with outstanding isotropic mechanical robustness are developed. The organohydrogels are prepared by introducing polyacrylamide (PAM) hydrogel, Zn2+ and a binary solvent of glycerol‐water into a crosslinked fibrous mat which is electrospun from poly(acrylic acid) (PAA) and poly(vinyl alcohol) (PVA). Because of the unique structure, the resultant organohydrogels, being mentioned as PAA‐PVA/PAM/Zn2+ organohydrogels, exhibit outstanding tensile strength (9.45 MPa), high stretchability, excellent anti‐fatigue property, skin‐like mechanical behaviors and ionic conductivity. Importantly, the organohydrogels are promising in flexible electronic devices capable of operating properly over a wide temperature range and under harsh mechanical conditions, such as mechanical‐electrical signal transducing materials in flexible mechanosensors and robust electrolytes in zinc ion hybrid supercapacitors. Not only the multiscale design strategy will provide a clue to improve the mechanical properties of soft materials, but also the organohydrogels offer promising materials for future flexible electronic devices.
Fungal Engineered Living Materials: The Viability of Pure Mycelium Materials with Self‐Healing Functionalities
Authors: Elsacker Elise , Zhang Meng , Dade‐Robertson Martyn 
Published: April 2023

AbstractEngineered living materials (ELMs) composed entirely of fungal cells offer significant potential due to their functional properties such as self‐assembly, sensing, and self‐healing. Alongside rapid developments in the ELM field, there is significant and growing interest in mycelium materials, which are made from the vegetative part of filamentous fungi, as a potential source of advanced functional materials. In order to advance the development of fungal ELMs that utilize the organism's ability to regenerate as self‐repair, new methods for controlling and optimizing mycelium materials are needed, as well as a better understanding of the biological mechanisms behind regeneration. In this study, pure mycelium materials are fabricated for use as leather substitutes, and it is found that chlamydospores, thick‐walled vegetative cells formed at the hyphal tip, may be the key to the material's self‐healing properties. The results suggest that mycelium materials can survive in dry and oligotrophic environments, and self‐healing is possible with minimal intervention after a two‐day recovery period. Finally, the study characterizes the mechanical recovery and physical properties of damaged and healed samples, allowing for the first characterization of fungal ELMs.
Controllable‐Swelling Microneedle–Assisted Ultrasensitive Paper Sensing Platforms for Personal Health Monitoring
Authors: Hsieh Yi‐Chia , Lin Chih‐Yu , Lin Hsin‐Yao , Kuo Chun‐Ting , Yin Shin‐Yi , Hsu Ying‐Hua , Yeh Hsiu‐Feng , Wang Jane , Wan Dehui 
Published: April 2023

AbstractMicroneedle (MN) patches, which allow the extraction of skin interstitial fluid (ISF) without a pain sensation, are powerful tools for minimally invasive biofluid sampling. Herein, an MN‐assisted paper‐based sensing platform that enables rapid and painless biofluid analysis with ultrasensitive molecular recognition capacity is developed. First, a controllable‐swelling MN patch is constructed through the engineering of a poly(ethylene glycol) diacrylate/methacrylated hyaluronic acid hydrogel; it combines rapid, sufficient extraction of ISF with excellent structural integrity. Notably, the analyte molecules in the needles can be recovered into a moist cellulose paper through spontaneous diffusion. More importantly, the paper can be functionalized with enzymatic colorimetric reagents or a plasmonic array, enabling a desired detection capacity—for example, the use of paper‐based surface‐enhanced Raman spectroscopy sensors leads to label‐free, trace detection (sub‐ppb level) of a diverse set of molecules (cefazolin, nicotine, paraquat, methylene blue). Finally, nicotine is selected as a model drug to evaluate the painless monitoring of three human volunteers. The changes in the nicotine levels can be tracked, with the levels varying significantly in response to the metabolism of drug in different volunteers. This as‐designed minimally invasive sensing system should open up new opportunities for precision medicine, especially for personal healthcare monitoring.
Managing Interfacial Defects and Carriers by Synergistic Modulation of Functional Groups and Spatial Conformation for High‐Performance Perovskite Photovoltaics Based on Vacuum Flash Method
Authors: Gao Deyu , Li Ru , Chen Xihan , Chen Cong , Wang Chenglin , Zhang Boxue , Li Mengjia , Shang Xueni , Yu Xuemeng , Gong Shaokuan , Pauporté Thierry , Yang Hua , Ding Liming , Tang JianXin , Chen Jiangzhao 
Published: April 2023

AbstractInterfacial nonradiative recombination loss is a huge barrier to advance the photovoltaic performance. Here, one effective interfacial defect and carrier dynamics management strategy by synergistic modulation of functional groups and spatial conformation of ammonium salt molecules is proposed. The surface treatment with 3‐ammonium propionic acid iodide (3‐APAI) does not form 2D perovskite passivation layer while the propylammonium ions and 5‐aminopentanoic acid hydroiodide post‐treatment lead to the formation of 2D perovskite passivation layers. Due to appropriate alkyl chain length, theoretical and experimental results manifest that COOH and NH3+groups in 3‐APAI molecules can form coordination bonding with undercoordinated Pb2+and ionic bonding and hydrogen bonding with octahedron PbI64−, respectively, which makes both groups be simultaneously firmly anchored on the surface of perovskite films. This will strengthen defect passivation effect and improve interfacial carrier transport and transfer. The synergistic effect of functional groups and spatial conformation confers 3‐APAI better defect passivation effect than 2D perovskite layers. The 3‐APAI‐modified device based on vacuum flash technology achieves an alluring peak efficiency of 24.72% (certified 23.68%), which is among highly efficient devices fabricated without antisolvents. Furthermore, the encapsulated 3‐APAI‐modified device degrades by less than 4% after 1400 h of continuous one sun illumination.
In Situ Growth of Metal‐Organic Framework Film for Flexible Artificial Synapse
Authors: Lu Qifeng , Xia Yizhang , Sun Fuqin , Shi Yixiang , Zhao Yinchao , Wang Shuqi , Zhang Ting 
Published: April 2023

AbstractThe realization of a neuromorphic system with high power efficiency and flexibility is of great significance in constructing bionic interaction systems. Although great improvement has been achieved, the systems based on hardware level remain with great challenges in device performance and stability under deformation due to the inferior interface quality. As a result, the neuromorphic systems are incompatible and incomparable with the biological ones. Therefore, an in situ growth method to synthesize the dielectric materials on flexible substrates, which can be used for the fabrication of flexible memristor‐type artificial synapses, is proposed to overcome the issues. A superiority in interface quality between the synthesized Cu3(BTC)2 Metal‐organic framework (MOF) material and the Cu foil substrate is observed benefiting from the in situ growth method, which will contribute to the improvement in device stability under deformation. In addition, the device shows continuous conductance states due to the highly accessible sites of the MOF. As a proof of concept, an artificial neural network based on the synaptic characteristics of the artificial synapse is designed, and high recognition accuracy of >80% is achieved, even with 30% allows conductance states. These results indicate that the proposed artificial synapse has great potential in the application of neuromorphic systems.
Fully Screen‐Printed Stretchable Organic Electrochemical Transistors
Authors: Boda Ulrika , Petsagkourakis Ioannis , Beni Valerio , Andersson Ersman Peter , Tybrandt Klas 
Published: April 2023

AbstractStretchable organic electrochemical transistors (OECTs) are promising for wearable applications within biosensing, bio‐signal recording, and addressing circuitry. Efficient large‐scale fabrication of OECTs can be performed with printing methods but to date there are no reports on high‐performance fully printed stretchable OECTs. Herein, this challenge is addressed by developing fully screen‐printed stretchable OECTs based on an architecture that minimizes electrochemical side reactions and improves long‐term stability. Fabrication of the OECTs is enabled by in‐house development of three stretchable functional screen‐printing inks and related printing processes. The stretchable OECTs show good characteristics in terms of transfer curves, output characteristics, and transient response up to 100% static strain and 500 strain cycles at 25% and 50% strain. The strain insensitivity of the OECTs can be further improved by strain conditioning, resulting in stable performance up to 50% strain. Finally, an electrochromic smart pixel is demonstrated by connecting a stretchable OECT to a stretchable electrochromic display. It is believed that the development of screen‐printed stretchable electrochemical devices, and OECTs in particular, will pave the way for their use in wearable applications and commercial products.
An Integrative Multiomics Framework for Identification of Therapeutic Targets in Pulmonary Fibrosis
Authors: Arif Muhammad , Basu Abhishek , Wolf Kaelin M. , Park Joshua K. , Pommerolle Lenny , Behee Madeline , Gochuico Bernadette R. , Cinar Resat 
Published: April 2023

AbstractPulmonary fibrosis (PF) is a heterogeneous disease with a poor prognosis. Therefore, identifying additional therapeutic modalities is required to improve outcome. However, the lack of biomarkers of disease progression hampers the preclinical to clinical translational process. Here, this work assesses and identifies progressive alterations in pulmonary function, transcriptomics, and metabolomics in the mouse lung at 7, 14, 21, and 28 days after a single dose of oropharyngeal bleomycin. By integrating multi‐omics data, this work identifies two central gene subnetworks associated with multiple critical pathological changes in transcriptomics and metabolomics as well as pulmonary function. This work presents a multi‐omics‐based framework to establish a translational link between the bleomycin‐induced PF model in mice and human idiopathic pulmonary fibrosis to identify druggable targets and test therapeutic candidates. This work also indicates peripheral cannabinoid receptor 1 (CB1R) antagonism as a rational therapeutic target for clinical translation in PF. Mouse Lung Fibrosis Atlas can be accessed freely at https://niaaa.nih.gov/mouselungfibrosisatlas.
Artificial Action Potential and Ionic Power Device Inspired by Ion Channels and Excitable Cell
Authors: Kim Jung‐Soo , Kim Jongwoon , Ahn Jinchul , Chung Seok , Han Chang‐Soo 
Published: April 2023

AbstractIn vivo, the membrane potential of the excitable cell working by ion gradients plays a significant role in bioelectricity generation and nervous system operation. Conventional bioinspired power systems generally have adopted ion gradients, but overlook the functions of ion channels and Donnan effect to generate efficient ion flow in the cell. Here, cell‐inspired ionic power device implementing the Donnan effect using multi‐ions and monovalent ion exchange membranes as artificial ion channels is realized. Different ion‐rich electrolytes on either side of the selective membrane generate the ion gradient potentials with high ionic currents and reduce the osmotic imbalance of the membrane. Based on this device, the artificial neuronal signaling is presented by the mechanical switching system of the ion selectivity like mechanosensitive ion channels in a sensory neuron. Compared with reverse electrodialysis, which requires a low concentration, a high‐power device with ten times the current and 8.5 times the power density is fabricated. This device activates grown muscle cells by increasing power through serial connection like an electric eel, and shows the possibility of an ion‐based artificial nervous system.
How ocean warming and acidification affect the life cycle of six worldwide commercialised sea urchin species: A review
Authors: Uboldi Thomas , Olivier Frédéric , Chauvaud Laurent , Tremblay Réjean 
Published: April 2023

AbstractOngoing global changes are expected to affect the worldwide production of many fisheries and aquaculture systems. Because invertebrates represent a relevant industry, it is crucial to anticipate challenges that are resulting from the current environmental alterations. In this review, we rely on the estimated physiological limits of six commercialised species of sea urchins (Loxechinus albus, Mesocentrotus franciscanus, Paracentrotus lividus, Strongylocentrotus droebachiensis, Strongylocentrotus intermedius and Strongylocentrotus purpuratus) to define the vulnerability (or resilience) of their populations facing ocean warming and acidification (OW&A). Considering that coastal systems do not change uniformly and that the populations’ response to stressors varies depending on their origin, we investigate the effects of OW&A by including studies that estimate future environmental mutations within their distribution areas. Cross‐referencing 79 studies, we find that several sea urchin populations are potentially vulnerable to the predicted OW&A as environmental conditions in certain regions are expected to shift beyond their estimated physiological limit of tolerance. Specifically, while upper thermal thresholds seem to be respected for L. albus along the SW American coast, M. franciscanus and S. purpuratus southern populations appear to be vulnerable in NW America. Moreover, as a result of the strong warming expected in the Arctic and sub‐Arctic regions, the local productivity of S. droebachiensis is also potentially largely affected. Finally, populations of S. intermedius and P. lividus found in northern Japan and eastern Mediterranean respectively, are supposed to decline due to large environmental changes brought about by OW&A. This review highlights the status and the potential of local adaptation of a number of sea urchin populations in response to changing environmental conditions, revealing possible future challenges for various local fishing industries.
Impact of zein and lignin‐PLGA biopolymer nanoparticles used as pesticide nanocarriers on soybean growth and yield under field conditions
Authors: Bonser Colin A. R. , Borgatta Jaya , White Jason C. , Astete Carlos E. , Sabliov Cristina M. , Davis Jeffrey A. 
Published: April 2023

AbstractNanoparticles are being utilized in agriculture as fertilizers, pesticides, and agrochemical‐carriers. Designed to be biocompatible and degradable, biopolymer nanoparticles were developed as an alternative to metallic nanoparticles, and though safe‐by‐design, polymeric nanoparticles must be field‐tested prior to largescale use. Several field studies were conducted to observe detrimental effects of biopolymer nanoparticles on plant growth and yield using soybean, Glycine max (L.) Merr., as a model system. Biopolymer nanoparticles made from lignin or zein were applied as seed treatments to soybean seeds or as foliar sprays (zein only) to soybean plants. Studies using biopolymer nanoparticle seed treatments (nano‐STs) measured the germination rates and seedling growth were evaluated in the laboratory, while stand counts, plant height, growth stage, yield, and hundred‐seed weight were measured in the field. Foliar treatments assessed nanoparticle impact on flower abortion and pod production. To ensure nano‐STs would not compromise the plant's defensive capabilities, herbivore feeding was assessed using a leaf bioassay for defoliators and a seed damage index for pod feeders. Growth rate, percent germination, or root length were not impacted by nano‐STs. In the field, nano‐STs had no impact on stand counts, heights, growth stage, yield, and hundred‐seed weights. Leaf feeding assays and damage indices indicate plant susceptibility to herbivore attack was not increased due to nano‐STs. Foliar applications of zein nanoparticles did not increase flower abortion or decrease pod set. These results indicate that biopolymer nanoparticles have no negative effects on growth, yield, and herbivore susceptibility and should be suitable for use in agriculture.
The Society for Craniofacial Genetics and Developmental Biology 45th Annual Meeting
Authors: Stottmann Rolf W. , Harris Matthew P. , Saint‐Jeannet Jean‐Pierre , Merrill Amy E. , Clouthier David E. 
Published: April 2023

AbstractThe Society for Craniofacial Genetics and Developmental Biology (SCGDB) held its 45th Annual Meeting at the Sanford Consortium for Regenerative Medicine at the University of California, San Diego on October 20th–21st, 2022. The meeting included presentation of the SCGDB Distinguished Scientists in Craniofacial Research Awards to Drs. Ralph Marcucio and Loydie Jerome‐Majewska and four scientific sessions that highlighted new discoveries in signaling in craniofacial development, genomics of craniofacial development, human genetics of craniofacial development and translational and regenerative approaches in craniofacial biology. The meeting also included workshops on analysis of single cell RNA sequencing datasets and using human sequencing data from the Gabriella Miller Kids First Pediatric Research Program. There were 110 faculty and trainees in attendance that represent a diverse group of researchers from all career stages in the fields of developmental biology and genetics. The meeting, which also included outdoor poster presentations, provided opportunities for participant interactions and discussions, thus strengthening the SCGDB community.
Association Between Rheumatoid Arthritis and Osteoporosis in Japanese Populations: A Mendelian Randomization Study
Authors: Deng Yunyang , Wong Martin Chi Sang 
Published: April 2023

ObjectiveThe positive association between rheumatoid arthritis (RA) and osteoporosis has been reported in previous observational studies, but the causal relationship remains unclear. This study was undertaken to investigate whether RA was causally associated with osteoporosis in Japanese populations using Mendelian randomization (MR) analyses.MethodsPublicly available summarized data from genome‐wide association studies (GWAS) on RA (4,199 cases and 208,254 controls) and osteoporosis (7,788 cases and 204,665 controls) were obtained from BioBank Japan. Eleven RA‐related single‐nucleotide polymorphisms (P < 5×10−8) were selected as instrumental variables. We used the inverse variance–weighted method as the primary method to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs). We also used the MR–Egger's method, weighted median, and weighted mode to determine the robustness of the main results. To partially test the horizontal pleiotropy, we used the MR–Egger's intercept test and the Mendelian randomization pleiotropy residual sum and outlier (MRPRESSO) test.ResultsUsing the inverse variance–weighted method, we showed that genetically predicted RA was positively associated with osteoporosis (OR 1.10, 95% CI 1.06–1.14, P < 0.001). The positive association was robust when we tested the results using the MR–Egger's method (OR 1.09, 95% CI 1.03–1.16, P = 0.023), weighted median (OR 1.09, 95% CI 1.04–1.15, P < 0.001), and weighted mode (OR 1.08, 95% CI 1.03–1.13, P = 0.012). Horizontal pleiotropy was not detected (P = 0.737) by the MR–Egger's intercept test or the MRPRESSO test.ConclusionOur results show a potential causal association between genetically predicted RA and osteoporosis. The finding was consistent when we used different MR methods and the sensitivity analysis. Further MR studies are needed when GWAS with more details of RA and osteoporosis performed in other East Asian/Japanese populations are available.image
Anatomists' uses of human skeletons: Ethical issues associated with the India bone trade and anonymized archival collections
Authors: Jones David Gareth 
Published: April 2023

AbstractConcerns have recently been expressed about the continuing availability of human bones from India, obtained originally for educational purposes but lacking the requisite informed consent that would be expected today. More generally, a broader claim is being made, namely, that the practice of using any unconsented bones in educational settings is unethical and should cease. These calls, in turn, raise broader issues regarding the availability of anonymous archival collections in anatomy museums. Although this debate centers on undergraduate anatomy teaching, much anthropological research utilizes human remains of past populations for which there can have been no consent. A suggested alternative for undergraduate teaching is the use of 3D images of human bones, rather than the bones themselves. In addressing these issues, the background to the India bone trade is assessed, and the year 1985 is pinpointed as having significant ethical weight. The cultural and ethical interests inherent in studying archival anonymous skeletal material are weighed against indiscriminate reburial. Although any use of unconsented material represents ethical compromise, account should be taken of changing ethical expectations with time. It is concluded that: there is no justification for repatriation or disposal of all bones for which specific informed consent has not been obtained; continued use of anonymous archival human bones in a professional setting is acceptable, even in the absence of informed consent, with the proviso that there are no culturally relevant groups seeking repatriation; the continued existence of bones in long‐standing private collections cannot be justified since it amounts to long‐term storage with no identified goals; the notion that 3D images are an ethically superior alternative to actual human bones is unsustainable, since there is an intimate connection between the bones and the 3D images.