bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D receptor polymorphisms among the Turkish population are associated with multiple sclerosis
Authors: Bulan B , Hoscan AY , Keskin SN , Cavus A , Culcu EA , Isik N , List EO , Arman A 
Published: February 2023

Abstract
Multiple sclerosis (MS) is an inflammatory disease characterized by demyelination and axonal degeneration affecting the central nervous system. Among the genetic factors suggested to be associated with this disease are polymorphisms to the vitamin D receptor (VDR) gene. We tested the hypothesis that polymorphisms in the vitamin D receptor (VDR) gene are associated with MS. The aim of the study was to investigate the relationship of MS with the VDR gene Fok-I, Bsm-I and Taq-I polymorphisms among the Turkish population. This study contains 271 MS patients and 203 healthy controls. Genomic DNA was isolated from the samples and the VDR gene Fok-I, Bsm-I and Taq-I polymorphism regions were amplified by polymerase chain reaction (PCR). The PCR products were digested, and the genotypes were determined based on size of digested PCR products. Our results demonstrate associations between MS and the distribution of the VDR gene Fok-I T/T polymorphism genotype in a dominant model, VDR gene Fok-I T allele frequency, distribution of VDR gene Taq-I C/C polymorphism genotype in a dominant model and VDR gene Taq-I C allele frequency (Pearson test, p<0.05). However, there was no association between MS and the VDR gene Bsm-I polymorphisms for the genotype distribution (Pearson test, p>0.05) or allele frequency (Pearson test, p>0.05). Fok-I and Taq-I VDR gene polymorphisms are significantly associated with MS in dominant, homozygote and heterozygote inheritance models among the Turkish population.
Transfer Factor of Radionuclides from Soil to Leafy Vegetables in Iraq Using Gamma Ray Spectroscopy
Authors: Jameel Athraa Naji 
Published: February 2023

The activity concentration of natural radioactivity levels, of artificial cesium and transfer factor from soil to plants in agricultural areas at Al- Yusiefya region were determined by using NaI (Tl) detector spectrometer. Ten species of leafy plants have been selected: Spinach, Parsley, Watercress, Lettuce, Rashad, Radish, Green onion, Turnip green, Green beet and Mint. The mean activity concentrations of 238U, 232Th, 40K and 137Cs in leafy vegetable samples were 12.4±3.8, 14.8±4.7, 283±93 and 1.06±0.99 Bg/kg, and in soil samples were 15.9±4.3, 16.1±5.2, 298.5±3.9, and 1.11±0.37 Bq/kg. The radiation hazard indices were evaluated (radium equivalent, external hazard index, annual effective dose, absorbed dose rate) were within the permissible values except for excess lifetime cancer risk. The mean transfer factor values of 226 Ra, 232Th, 40K, and 137Cs were 0.89±0.2, 0.9±0.2 , 1.02±0.3, and 0.77±0.25. The leafy vegetable are safe for consumption and the studied area does not pose a considerable radiological threat .
Morphotectonic Analysis of Wadi Al-Batin Alluvial Fan, South of Iraq, Using Remote Sensing and GIS Techniques
Authors: Albhadili Suaad , Almallah Inass , Almulla Saher 
Published: February 2023

This research aimed to know the tectonic activity of the Wadi Al-Batin alluvial fan using hydrological and morphotectonic analyses. Wadi Al-Batin alluvial fan is deposited from Wadi Al-Rimah in Saudi Arabia, which extended to Iraqi and Kuwait international boundaries. The longitudinal and transverse faults that characterize this region were common. The Abu- Jir-Euphrates faults have a significant impact on the region. The faults zone consists of several NW- SE trending faults running from the Rutba in western Iraq to the south along the Euphrates through Kuwait and meeting the Al-Batin fault to the Jal Al-Zor fault. The Hydromorphometric analysis of the present fan shows five watersheds having asymmetry shapes, more elongated and activity from the elongation ratio and asymmetry factor values. In contrast, transverse topographic symmetry and mountain front sinuosity factor have moderate to low activity from the stream length gradient index. The morphotectonic analysis suggests that the Wadi Al-Batin alluvial fan has a moderate tectonic activity due to the tectonic activity of the subsurface lineaments and the oil field activities found in the region.
Assessment of miR-146a Gene Polymorphisms in Patients with Systemic Lupus Erythematosus
Authors: Abdulridha Ruaa Hameed , Saud Asmaa Mohammed , Alosami Mohammed Hadi 
Published: February 2023

Systemic lupus erythematosus (SLE) is a multifactorial chronic autoimmune disease, with a wide spectrum of effect. The main feature of the disease is the production of a wide variety of autoantibodies as a result of immune tolerance loss. The work aims to evaluate the miRNA-146a gene polymorphism potential association with disease activity and chronicity changes in SLE patients. The study included 100 SLE patients and 50 matched controls. The systemic lupus erythematosus disease activity index (SLEDAI) was assessed. The single nucleotide polymorphism (SNP) of miR-146a gene (rs2910164) polymorphism was assayed by polymerase chain reaction (PCR) and sequencing technique in patients and control. 100 SLE patients were all females and with a mean of age 31.3 ± 10 years (16-63years) and disease duration of 5.8 ± 3.7years (1 month to 15 years). Most clinical manifestations presented in patients were 52% malar rash, 45% oral ulcers, 54% arthritis, and 45% neurological disorder. Proteinuria, ESR, creatinine and AST were significantly higher (65% vs. 10%, 4.1±36.1 vs. 11.8±9.9 mm/hr, 0.62±0.11 vs. 0.70±0.14 mg/dl and 25.37±26.50 vs. 17.23±3.58 U/L respectively) while the PLT was significantly lower (231.9±88.8 vs. 282.3±67.3 103/mL) (p< 0.001) among SLE patients as compared to control. There were no significant variations in all study parameters across miRNA-146a genotypes (p greater than 0.05). There was a significant association of the homozygote GG genotype (66.7%) with the active SLE state (p=0.013). In conclusion, the results suggest a risk effect for the female gender and adult at a young age in the etiology of SLE. The miRNA-146a GG genotype is associated with increasing the disease activity and miRNA-146a polymorphism is not associated with the risk in SLE.
PERANCANGAN ULANG TATA LETAK FASILITAS MENGGUNAKAN METODE ARC GUNA MEMAKSIMALKAN PRODUKTIVITAS PEKERJA PADA PEMBUATAN ROKOK DI CV ROTAMA TASIKMALAYA
Authors: Kurnia Yusup , Tresna Mahendra Iqbar 
Published: February 2023

Penelitian hanya dilakukan pada pabrik roko CV Rotama. Penelitian menggunakan data dari hasil observasi serta hasil pengumpulan data melalui wawancara.Peneliti hanya memprioritaskan pada perancangan ulang tata letak pasilitas pabrik rokok CV Rotama, yang kemudian di evaluasi menggunakan ARC.Adapun cara yang dilakukan untuk merancang ulang tata letak fasilitas di pabrik rokok CV Rotama yauitu, Studi Pustaka, Studi lapang, mengevaluasi data tersebut dengan metode Activity Relationship chart (ARC,), layout usulan.
Berdasarkan metode Activity Relationship chart (ARC) menghasilkan aliran produksi yang lebih efektif dan efesien sehingga tidak terjadi Back Tracking atau alur bolak balik. proses produksi menjadi lebih teratur dan maksimal. Jarak perpindahan material lebih efektif dan efisien dan waktu tempuh perpindahan material produksi awalnya 21 meter yang harus ditempuh dalam satu proses produksi. Desain usulan waktu yang dibutuhkan dalam satu kali proses produksi memerlukan waktu 9 meter. Di setiap produksi bisa mengurangi jarak tempuh sekitar 1-4 meter.
HUBUNGAN PENEMPATAN KERJA KARYAWAN DENGAN EFEKTIVITAS KERJA KARYAWAN PADA CV. ANYAR PUTRA CIAMIS
Authors: Setiari Idan 
Published: February 2023

Pengamatan awal menunjukan bahwa efektivitas kerja karyawan CV. Anyar Putra Ciamis belum optimal, indikator yang terlihat meliputi ; masih adanya karyawan yang belum mempunyai kemampuan yang baik dalam melaksanakan pekerjaannya, dan masih terdapat karyawan yang belum menganggap penting kualitas diri dan upaya peningkatannya.
Belum optimalnya efektivitas kerja karyawan diduga penyebabnya karena penempatan yang kurang sesuai dengan kaidah penempatan yang baik, yaitu penempatan karyawan pada posisi yang sesuai dengan kemampuannya atau kurang diperhatikannya penempatan karyawan yang tepat pada tempat yang tepat pula (the right man on the right place) dengan memperhatikan pendidikan, kesehatan, dan pengalaman karyawan.
Tujuan penelitian ini adalah untuk mengetahui penempatan karyawan, mengetahui efektivitas kerja karyawan, dan mengetahui hubungan penempatan karyawan dengan efektivitas kerja karyawan pada CV. Anyar Putra Ciamis. Kemudian kegunaan penelitian ini untuk pengembangan ilmu pengetahuan ekonomi manajemen, memberikan sumbangan pengetahuan yang berkaitan dengan masalah penempatan karyawan dan efektivitas kerja karyawan, serta memberi sumbangan pemikiran bagi CV. Anyar Putra Ciamis dalam memformulasikan strategi penempatan karyawan.
Metode penelitian yang digunakan adalah metode deskriptif analisis. Teknik pengumpulan data melalui observasi, wawancara, dan kuisioner. Teknik analisis data digunakan uji validitas,, uji reliabilitas. Analisis untuk pengukuran data menggunakan koefisien korelasi Rank Spearman, sedangkan pengujian hipotesis menggunakan uji t.
Berdasarkan hasil analisis statistik dengan menggunakan koefisien korelasi diketahui bahwa penempatan karyawan mempunyai hubungan yang erat dan signifikan dengan efektivitas kerja karyawan sebesar 0.790 %. Hasil pengujian hipotesis menunjukan bahwa terdapat hubungan yang signifikan antara penempatan karyawan dengan efektivitas kerja karyawan pada CV. Anyar Putra Ciamis.
Hasil penelitian dapat disimpulkan bahwa penempatan karyawan sudah kategori baik, namun demikian dalam beberapa hal belum optimal, oleh karena itu diperlukan perbaikan penempatan sesuai dengan deskripsi dan spesifikasi jabatan serta berpedoman kepada penempatan yang tepat sesuai dengan pendidikan dan keahliannya. Begitu pula dengan efektivitas kerja karyawan sudah kategori baik, namun keberadaan (posisi) belum mencapai tingkatan yang paling maksimal. Artinya hal ini diperlukan upaya lebih dari pimpinan untuk menciptakan suasana kondusif dan menciptakan motif individu untuk berpartisipasi secara efektif.
The Effectiveness of Polydioxanone (PDO) Thread-Embedding Acupuncture in Adult Patients with Obesity: Case reports
Authors: Nareswari Irma , Fredy Diana Marsha , Notonegoro Cindy , Meitaqwatiningarum Fieka 
Published: February 2023

Background: Obesity is a chronic condition defined as excess body fat which is diagnosed based on body mass index, abdominal circumference, and is associated with an increased risk of various diseases. Conservative management is often hard to comply with, unsuccessfully, and expensive, while acupuncture with its variety of modalities can be an option.
Case: A therapy with polydioxanone thread embedding on acupuncture points along with other acupuncture modalities were performed in three cases of obese patients according to their etiology and conditions.
Results: Based on the three cases of obese patients with PDO thread embedding acupuncture alone or combined with cupping, plum blossom and moxibustion modalities are beneficial in decreasing abdominal circumference. The effect after 2 months follow up respectively using abdominal circumference measurement 5 cm above the umbilicus -2 cm ( from 110 to 99cm);- 3 cm (from 90 to 87 cm); -8 cm (from 88 to 80 cm), umbilicus to umbilicus -6 cm (from 107 to 101 cm); 10 cm (from 103 to 93 cm); 7 cm (from 93 to 86 cm), 5 cm below umbilicus -1 cm (from 106 to 105 cm); -5 cm (from 107.5 to 102.5 cm); -6 cm (from 104 to 98 cm). No serious side effects occurred in the three cases.
Conclusion: PDO thread embedding can be beneficial in treating obese patients. However, these results require further research.
Utilizing Digital Enabler to Attain Excellent Safety, Security, Health, and Environmental Performance
Authors: Tiengtrong Wannoptida , Suwannaposi Rachamon , Klunngien Chagun 
Published: February 2023

Abstract
This paper explains how digital enabler can help an organization enhance the Safety, Security, Health, and Environmental (SSHE) awareness of employees and contractors and compliance with SSHE requirements. The unique features of digital enabler are creatively designed to provide a set of solutions for managing SSHE data that meet the needs of the oil and gas industry. It is an innovative digital solution that helps the organization achieve excellent SSHE performance.
The PTTEP digital enabler, iSSHE, is developed to support the SSHE management system and respond to current and emerging SSHE challenges. It can help an organization collect, manage, and analyze SSHE data to prevent incidents while maintaining operations, complying with regulatory changes, and improving sustainability. Reporting SSHE data is just the beginning. With iSSHE, on the other hand, we can shift our focus from reactive compliance with applicable requirements to proactive performance management with an integrated SSHE management approach.
The goal of iSSHE is to ensure SSHE data and resources are well-collected, managed, and shared across business units to fuel forward-looking results for continuous SSHE performance improvement. This integrated approach connects stakeholders, information, and insights across the entire risk value chain.
iSSHE solution combines a responsive, configurable, and intuitive cloud-based platform. It enables better decisions and optimizes SSHE performance. Adopting SSHE digital technology transforms all SSHE-related information and implementation by replacing non-digital or manual processes with digital ones.
The key benefits of utilizing digital enablers to support the SSHE management system are as follows:
Reducing the scope for errors in data reporting Saving time while increasing productivity Improving SSHE performance Connecting employees and contractors across different departments and locations in the organization Standardizing and centralizing SSHE data Lessening risks and building safety awareness Helping manage regulations and stay compliant Serving to predict future performance with analytics of historical data Driving insights that enable better and more sustainability decisions
The Borehole Properties Analysist Using Advanced Algorithms and Automatic Inversion
Authors: Hermawan Manuaba Ida Bagus Gede , Jad Kareem Mohammad , Al Mubarak Mustafa , Santoso Gagok 
Published: February 2023

AbstractThe study is based on multi well analysist drilled side by side in carbonate reservoir using high-resolution resistivity image. The objective is to define reservoir characterization, facies architecture, heterogeneity, and connectivity between two wells that is ready for reservoir modeling.The methods presented in this paper are using an automatic inversion and advanced algorithm to generate matrix conductivity images and curves, histogram, analyses rock texture heterogeneities, quantify fluid filled vugs density from high resolution borehole images, fast extraction of dips (beds, fractures), delineate planar features crossing deviated borehole over long distances, extract fracture traces and statistics.More than 3,000 picks of boundaries and fractures were found in a 3,300 ft horizontal length. Those divided into 6 different categories (Bed Boundary, Conductive Fracture, Discontinuous Conductive Fracture, Resistive Fracture, Litho-Bound Fracture, and Vugular fracture). Using high-definition imaging-while-drilling service provides supreme logging-while-drilling (LWD) imaging for reservoir description, from structural modeling, sedimentology analysis, image-based porosity determination and thin-bed analysis.The presence of heterogeneity in carbonates poses a challenge for the characterization of such rocks. The identification of textural variations advanced techniques in borehole image analysis have been applied and presented good results that determine secondary porosity and litho-facies, and, moreover, delivered new insight into previously established interpretations of the reservoir. The data comparison and validation to other measurement show a significant relationship to bring the value even beyond. By using an automatic inversion, the geological interpretation can be constantly delivered around the clock with higher consistency with the number of feature variation.It has been demonstrated that with the advanced analysis, microelectrical borehole images can provide quantitative measures of important reservoir parameters. Accuracy and consistency have been greatly improved since the introduction of microelectrical borehole image logging and subsequent automatic interpretation workflows.
Innovative Use of Transient Flow Modelling for Successful Planning and Execution of Complex High Pressure (HHP) Well Unloading: Plan and Results
Authors: Maheshwari Rahul , Ure Duncan , Cheong Cynthia Sing Yueh 
Published: February 2023

AbstractUnloading wells post drilling and completion is critical in ensuring risk of well productivity impairment due to extended residence of drilling and completion fluids in the well is minimized. In addition, unloading high pressure (HHP) gas wells can be quite complex since it includes rapid changes in operating conditions (pressure, temperatures and rates), which if not planned properly, can lead to exceeding design operating envelopes and in the worst-case result in process safety incidents. The objective of this paper is to present a case study, which demonstrates the application of transient flow modelling for analysis of complex high pressure (HHP) gas well unloading.Traditional well and surface network modelling tools and softwares use steady state flow models. However, well unloading is a transient phenomenon with rapid changes in pressure, temperature, flowrate and hold-up and ideally requires multiphase transient flow modelling software to predict the conditions accurately. This paper describes how transient flow simulation, using the software package OLGA, was applied to model well unloading with the objective to keep the flow within the operating envelope of the well and surface equipment.The execution was carried out safely and successfully aided by the modelling work carried out in OLGA. A comparison of the modelled and actual measured parameters is presented showcasing the utility of transient flow modelling in planning, decision making and smooth execution. The model was used to optimize the choke positions within the constraints of low temperature limit, while avoiding the requirement of heat exchangers, steam generators and flare stack and avoid a long learning curve during execution. This also ensured that flaring was not required which means no Greenhouse Gas (GHG) emissions and the produced hydrocarbons were monetized.
The Accurate Pore Pressure Prediction with Coupled Geomechanical and Thermodynamics Model
Authors: Yuan Shuwu , Zhou Wei , Li Ting , Wang Hui , Peng Xuehong , Xiao Long , Luo Xudong , Zhai Zhihong , Ding Haifan , Tian Chaobin , Deng Yantao , Huang Xingning 
Published: February 2023

AbstractReservoir pressure and pore pressure coefficient are the key parameters for evaluating the preservation conditions of low permeability reservoirs and selecting different development processed and measures, as well as important input parameters for predicting ground stress. Due to the influence of unique geological characteristics such as ancient structure, current structure and rapid change of burial depth, the pore pressure in reservoir of the Upper Wuerhe Formation in the 53 east block of Junggar Basin has a large lateral change and is influenced by many factors. The conventional pore pressure prediction methods based on longitudinal wave velocity (such as Eaton method) have poor accuracy. Therefore, according to the geological characteristics of the reservoir in this area, based on the simultaneous inversion of P-wave and S-wave data before seismic stack, combined with the changes in formation lithology and the impact of denudation on pore pressure and pore pressure coefficient, this paper takes P-wave, S-wave, lithology, and denudation into account to predict pore pressure and pressure coefficient. The research results show that: ① the introduction of seismic inversion data improves the prediction accuracy and detail richness on the plane; ② the introduction of the lithology change factor improves the stability of the prediction of pressure coefficient in vertical direction; ③ for the area suffering from strong denudation, the introduction of denudation intensity help better predict the pressure coefficient of low pressure wells near the denudated area. The pressure data from more than 10 actual wells proves that the relative error of the prediction results of this method is less than 5%. It is concluded that the established prediction method has small error and high accuracy, and can be used to provide higher quality data support for the subsequent selection of good reservoirs, well location deployment, horizontal stress parameter prediction.
Mitigating Sustained Casing Pressure in the Denver-Julesburg Basin with a Low Permeability Flow Resistant Cementing Solution
Authors: Clark Brittany Elbel , Pearl William , Hopwood Dale 
Published: February 2023

AbstractSustained casing pressure (SCP) is an industry wide challenge, and the evaluation and validation of a new cement system proactively mitigates SCP defending against numerous flow mechanisms, by delivering a barrier that minimizes fluid loss, shortens transition time, improves shear bonding, and reduces permeability. The application of this new cement system in the Denver-Julesburg Basin demonstrates its ability to mitigate and reduce the occurrence of SCP both pre and post fracturing while delivering a more efficient and sustainable solution.The innovative chemistry of the cement system enables an efficient delivery of a dry blended system, providing enhanced cement properties without the need for premium liquid additives. The system was evaluated in the laboratory to mitigate SCP caused by flow through unset cement as well as evaluated for its long-term integrity to better withstand stresses placed on the cement sheath during fracturing operations. Pre and post frac SCP are well documented and monitored across the Denver-Julesburg (D-J) basin and the new cement system was pumped on over 200 wells and has shown a reduction in both pre- and post-fracturing SCP (COGCC 2022).The SCP mitigation cement system can deliver over a 40% increase in shear bond strength, increasing the anchoring forces the cement sheath has to the casing and formation while proving to be a more crack resistant barrier. With a 75% reduction in cement permeability, it has increased resistance to flow and degradation from corrosive fluids or gases.The cement system enables operators to proactively mitigate SCP, minimize risk, and limit their carbon footprint by eliminating the need for future remediation and can be tailored and applied to other basins with similar challenges across the globe to mitigate SCP and improve long term well integrity
Revealing the Hikurangi Subduction Zone with Joint Sparse OBN and Streamer FWI
Authors: Gong Zongying , Gao Xinyue , Wu Xiaodong , Xie Yi , Hung Barry , Bangs Nathan 
Published: February 2023

AbstractFull-waveform inversion (FWI) utilizing long-offset ocean bottom node (OBN) data has become a key velocity model building tool for resolving complex velocities for deeper targets. Acquiring such OBN datasets with dense shot and receiver sampling remains costly. Sparse OBN data has been studied in recent years to reduce acquisition expense while maintaining desired benefits for FWI. Whereas sparse OBN data can provide velocities comparable to dense OBN data, it alone cannot provide seismic images and gathers fit for interpretation purposes. We demonstrate a cost-effective approach using joint sparse OBN and streamer FWI that effectively updates the deep velocity of a complex subduction zone in the Hikurangi margin near New Zealand's East Coast. The streamer data is then migrated to provide detailed and accurate images fit for interpretation.