bluuebunny/crossref_metadata_2025_split huggingface dataset:
An immersive field trip focused on beef production increases the sense of belonging in ethnoracial minority college students
Authors: Drewery Merritt L , Cooper Jade V , Waliczek Tina M , Wickersham Tryon A 
Published: January 2023

Abstract
Sense of belonging is a student’s sense of feeling accepted, valued, and included by others in their discipline. Imposter syndrome is self-perceived intellectual fraud in areas of success. Sense of belonging and imposter syndrome can influence behavior and well-being and are linked to academic and career outcomes. Our objective was to evaluate if a 5-d tour of the beef cattle industry changed college students’ sense of belonging and imposter tendencies with a focus on ethnicity/race. Procedures involving human subjects were approved by the Texas State University (TXST) IRB (#8309). Students from TXST and Texas A&M University (TAMU) attended a beef cattle industry tour in the Texas Panhandle in May 2022. Identical pre- and post-tests were administered immediately before and after the tour. Statistical analyses were conducted with SPSS v.26. Independent sample t-tests were used to evaluate the change from pre- to post-survey and one-way ANOVA was used to evaluate the effect of ethnicity/race. Students (n = 21) were mostly female (81%); attended TAMU (67%) or TXST (33%); and were White (52%), Hispanic (33%), or Black (14%). “Hispanic” and “Black” were combined as a single variable to analyze differences between White and ethnoracial minority students. Before the tour, there was a difference (P = 0.05) in sense of belonging in agriculture between White (4.33 ± 0.16) and ethnoracial minority (3.73 ± 0.23) students such that White students had stronger belonging. There was no change (P = 0.55) in White students’ sense of belonging as a result of the tour, from 4.33 ± 0.16 to 4.39 ± 0.44. However, there was a change (P ≤ 0.01) in ethnoracial minority students’ sense of belonging, from 3.73 ± 0.23 to 4.37 ± 0.27. There was no change (P = 0.36) in imposter tendencies from the pre-test (58.76 ± 2.46) to the post-test (60.52 ± 2.79). Ultimately, participating in the tour increased ethnoracial minority, but not White, students’ sense of belonging and did not impact imposter syndrome tendencies across or within ethnicity/race. One benefit of implementing experiential learning opportunities in dynamic social environments is the potential to improve students’ sense of belonging, especially in disciplines and careers where ethnoracial minority people are underrepresented.
The effects of increasing dietary total Ca/total P ratios on growth performance, Ca and P balance, and bone mineralization in nursery pigs fed diets supplemented with phytase
Authors: Zhai Hengxiao , Bergstrom Jon , Zhang Jingcheng , Dong Wei , Wang Zhenzhen , Stamatopoulos Kostas , Cowieson Aaron J 
Published: January 2023

Abstract
The objective of this study was to investigate the effects of increasing dietary total Ca/total P ratios on growth performance, digestibility of Ca and P, bone mineralization, and concentrations of Ca and P in urine and plasma in nursery pigs. There were six diets in a randomized complete block design, including one positive control and five diets corresponding to five total Ca/total P ratios: 0.55, 0.73, 0.90, 1.07, and 1.24 (analyzed as 0.58, 0.75, 0.93, 1.11, and 1.30). These five diets were deficient in P but supplemented with 1,000 phytase units/kg feed. Each diet was fed to six pens of eight pigs (four barrows and four gilts per pen). All diets contained 3 g/kg TiO2, and fecal samples were collected from each pen on days 5–7 of trial. At the end, one pig per pen was sacrificed to collect the right tibia and urine in the bladder. The results showed that increasing dietary Ca/P ratio to 0.93 increased gain:feed but then gain:feed decreased as the Ca/P ratio was increased to 1.30 (linear and quadratic, P &lt; 0.05). Although average daily gain and final BW were unaffected by changing Ca/P ratio in diet, dry bone weight; weights of bone ash, Ca and P; and bone Ca/P ratio increased linearly (P &lt; 0.001) with increasing dietary Ca/P ratio. The percent bone Ca showed a tendency to increase (P = 0.064). Increasing dietary Ca/P ratio decreased apparent total tract digestibility (ATTD) of Ca and P linearly (P &lt; 0.05) and the concentration of digestible P linearly (P &lt; 0.001), but increased the concentration of digestible Ca (linear and quadratic effects: P &lt; 0.01) and the digestible Ca/P ratio (linear effect: P &lt; 0.001). In plasma, the concentration of Ca increased both linearly (P &lt; 0.01) and quadratically (P = 0.051), whereas the concentration of P tended (linear and quadratic, P &lt; 0.10) to decrease with increasing dietary Ca/P ratio. Similarly, in urine, the concentration of Ca increased both linearly and quadratically (P &lt; 0.05), whereas the concentration of P decreased linearly (P &lt; 0.01). In conclusion, increasing the dietary Ca/P ratio reduced feed efficiency but increased bone mass and the amounts of Ca and P deposited in bone of nursery pigs fed diets supplemented with 1,000 FYT/kg phytase. The increases in bone growth led to a reduction of urinary P excretion that exceeded the decreased digestible P supplied in diet with the widening dietary Ca/P ratios.
‘What did you do to them Klaus?’: The Klaus Fuchs Atomic Espionage Case and its Impact on the Scientific Community in early Cold War Britain
Authors: Kassimeris George , Price Oliver 
Published: January 2023

Abstract
The atomic spy, Klaus Fuchs, was one of the most notorious figures of the early Cold War. The story of his espionage and the impact it had has been the subject of extensive historical research. This article provides a new angle on the Fuchs case by examining the repercussions of his actions on his friends, colleagues, and the wider scientific community in Britain that have previously been overlooked. It argues that the subsequent fall-out led several atomic scientists to have their own loyalties questioned and be subjected to extensive and sustained surveillance. As the article will show, the inevitable era of suspicion that the Fuchs case ushered in did damage to the reputations, careers, and prospects of certain scientists. By examining the repercussions, the article helps to provide a first insight into the experience of some British scientists during the early years of the Cold War.
Robot-assisted versus open hepatectomy for liver tumors: Systematic review and meta-analysis
Authors: Xuea Qian , Wua Jianping , Leia Zehua , Wanga Qing , Fua Jinqiang , Gaoa Fengwei 
Published: January 2023

Background:
This meta-analysis was conducted to evaluate the effectiveness and safety of robot-assisted hepatectomy (RAH) versus open hepatectomy (OH) for liver tumors (LT).

Methods:
A computer-based literature search was conducted to identify all randomized or nonrandomized controlled trials of RAH and OH in the treatment of LT from January 2000 to July 2022. Study-specific effect sizes and their 95% confidence intervals (CIs) were combined to calculate the pooled values, using a fixed-effects or random-effects model.

Results:
Eight studies were included, with a combined total of 1079 patients. Compared with the OH group, the RAH group was found to involve less blood loss (standardized mean difference [SMD] = −152.52 mL; 95% confidence interval [CI] = −266.85 to 38.18; p = 0.009), shorter hospital stay (SMD = −2.79; 95% CI = −4.19 to −1.40; p < 0.001), a lower rate of postoperative complications (odds ratio [OR] =0.67; 95% CI = 0.47–0.95; p = 0.02), and a lower recurrence rate (OR = 0.42; 95% CI = 0.23–0.77; p = 0.005). However, operative time was longer in the RAH group than in the OH group (SMD = 70.55; 95% CI = 37.58–103.53; p < 0.001).

Conclusion:
This systematic review shows that RAH is safe and feasible in the treatment of LT.
Mass Spectrometry Proteomic Analysis of Four p53 Patterns in Differentiated Vulvar Intraepithelial Neoplasia
Authors: Jamaluddin M. Fairuz B. , Day Tania , Tanwar Pradeep S. , Marzol Alexandra , Scurry James 
Published: January 2023

Objective
The histopathologic diagnostic criteria of differentiated vulvar intraepithelial neoplasia (dVIN), the precursor of human papillomavirus-independent squamous cell carcinoma, are basal atypia, a negative or non–block-positive p16, and a supportive p53 immunohistochemistry (IHC). Several different patterns of supportive p53 IHC have been described. This study aims to determine the relationship between p53 IHC patterns and mass spectrometry analysis of cellular proteins in dVIN.

Methods
Four patterns of p53 IHC were studied: overexpression, cytoplasmic, wild type, and intermediate expression between wild type and overexpression. For each pattern, tissue samples of 4 examples were subjected to mass spectrometry.

Results
The protein profile within each p53 IHC pattern shared common features. Each of the 4 p53 patterns had a distinguishable protein profile when compared with the other 3 patterns.

Conclusions
The distinguishable protein profiles in different p53 IHC patterns suggest diverse mechanisms of TP53 dysfunction. Subtyping dVIN by p53 IHC is worthy of further study because varied protein expression profiles may translate into different clinical behavior.
Improved beta-binomial estimation for reliability of healthcare quality measures
Authors: Zhou Guohai , Lin Zhenqiu 
Published: January 2023

AbstractBackgroundThe popular beta-binomial approach to estimate the reliability of healthcare quality measures (Adams et al. 2010New England Journal of Medicine) may yield grossly over-estimated reliabilities for providers with event rates equal to 0% or 100%.ObjectiveImprove the beta-binomial approach to yield more reasonable reliability estimates for providers with event rates equal to 0% or 100%.MethodWe revise the beta-binomial approach by substituting Bayesian estimates with various priors for the crude event rates. We evaluate the new reliability estimates using Monte Carlo studies and two real-world measure examples.Results and conclusionThe revised beta-binomial approach based on Jeffreys non-informative prior yields more reasonable reliability estimates for providers with event rates equal to 0% or 100% and statistically outperforms the original beta-binomial approach regarding bias and standard errors.
Household antibiotic use in Malawi: a cross-sectional survey from urban and peri-urban Blantyre
Authors: MacPherson Eleanor E , Mankhomwa John , Dixon Justin , Pongolani Raymond , Phiri Mackwellings , Feasey Nicholas , O’Byrne Thomasena , Tolhurst Rachel , MacPherson Peter 
Published: January 2023

AbstractBackgroundAntimicrobial resistance (AMR) is a significant threat to public health. Use of antibiotics, particularly in contexts where weaker regulatory frameworks make informal access easier, has been identified as an important driver of AMR. However, knowledge is limited about the ways antibiotics are used in communities in sub-Saharan Africa.MethodsBetween April and July 2021, we undertook a cross-sectional survey of community antibiotic use practices in Blantyre, Malawi. We selected two densely-populated neighbourhoods (Chilomoni and Ndirande) and one peri-urban neighbourhood (Chileka) and undertook detailed interviews to assess current and recent antibiotic use, supported by the innovative “drug bag” methodology. Regression modelling investigated associations with patterns of antibiotic recognition.ResultsWe interviewed 217 households with a total of 1051 household members. The number of antibiotics recognised was significantly lower among people with poorer formal health care access (people with unknown HIV status vs. HIV-negative, adjusted odds ratio [aOR]: 0.76, 95% CI: 0.77-.099) and amongst men (aOR: 0.83, 95% CI: 0.69-0.99), who are less likely to support healthcare-seeking for family members. Reported antibiotic use was mostly limited to a small number of antibiotics (amoxicillin, erythromycin and cotrimoxazole), with current antibiotic use reported by 67/1051 (6.4%) and recent use (last 6 months) by 440/1051 (41.9%).ConclusionsOur findings support the need for improved access to quality healthcare in urban and periurban African settings to promote appropriate antibiotic use and limit the development and spread of AMR.
UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease
Authors: Collins Amy , Scott Rebecca , Wilson Caroline L , Abbate Giuseppe , Ecclestone Gabrielle , Biddles Demi , Oakley Fiona , Mann Jelena , Mann Derek A , Kenneth Niall S. 
Published: January 2023

AbstractLiver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in most types of chronic liver diseases. Fibrosis is associated with the activation of hepatic stellate cells (HSCs) which transdifferentiate into a myofibroblast like phenotype that is contractile, proliferative and profibrogenic. Hypoxia-inducible factor 1 (HIF1), an oxygen-sensitive transcription factor, is elevated during HSC activation and promotes the expression of profibrotic mediator HIF target genes. HIF activation during HSC activation can by either due to localised decreases in oxygen levels, or through oxygen-independent mechanisms that are not completely understood. Here we describe a role for the deubiquitinase UCHL1 in regulating HIF levels and activity during HSC activation and liver fibrosis. Increased HIF1α expression correlated with induction of UCHL1 mRNA and protein with HSC activation. Genetic deletion or chemical inhibition of UCHL1 impaired HIF activity through reduction of HIF1α levels. UCHL1 specifically cleaves the degradative ubiquitin chains from HIF1α leading to increased HIF1α levels, even in sufficiently oxygenated cells. Furthermore, our mechanistic studies have shown that UCHL1 elevates HIF activity through specific cleavage of degradative ubiquitin chains, elevates levels of pro-fibrotic gene expression and increases proliferation rates. These results demonstrate how small molecule inhibitors of DUBs can modulate the activity of HIF transcription factors in liver disease. Furthermore, inhibition of HIF activity via modulation of the ubiquitin-proteasomal degradation pathway may represent a therapeutic opportunity with other HIF-related pathologies.Abstract Figure
Unlockingde novoantibody design with generative artificial intelligence
Authors: Shanehsazzadeh Amir , McPartlon Matt , Kasun George , Steiger Andrea K. , Sutton John M. , Yassine Edriss , McCloskey Cailen , Haile Robel , Shuai Richard , Alverio Julian , Rakocevic Goran , Levine Simon , Cejovic Jovan , Gutierrez Jahir M. , Morehead Alex , Dubrovskyi Oleksii , Chung Chelsea , Luton Breanna K. , Diaz Nicolas , Kohnert Christa , Consbruck Rebecca , Carter Hayley , LaCombe Chase , Bist Itti , Vilaychack Phetsamay , Anderson Zahra , Xiu Lichen , Bringas Paul , Alarcon Kimberly , Knight Bailey , Radach Macey , Bateman Katherine , Kopec-Belliveau Gaelin , Chapman Dalton , Bennett Joshua , Ventura Abigail B. , Canales Gustavo M. , Gowda Muttappa , Jackson Kerianne A. , Caguiat Rodante , Brown Amber , Ganini da Silva Douglas , Guo Zheyuan , Abdulhaqq Shaheed , Klug Lillian R. , Gander Miles , Yapici Engin , Meier Joshua , Bachas Sharrol 
Published: January 2023

AbstractGenerative AI has the potential to redefine the process of therapeutic antibody discovery. In this report, we describe and validate deep generative models for thede novo designof antibodies against human epidermal growth factor receptor (HER2) without additional optimization. The models enabled an efficient workflow that combinedin silicodesign methods with high-throughput experimental techniques to rapidly identify binders from a library of ∼106heavy chain complementarity-determining region (HCDR) variants. We demonstrated that the workflow achieves binding rates of 10.6% for HCDR3 and 1.8% for HCDR123 designs and is statistically superior to baselines. We further characterized 421 diverse binders using surface plasmon resonance (SPR), finding 71 with low nanomolar affinity similar to the therapeutic anti-HER2 antibody trastuzumab. A selected subset of 11 diverse high-affinity binders were functionally equivalent or superior to trastuzumab, with most demonstrating suitable developability features. We designed one binder with ∼3x higher cell-based potency compared to trastuzumab and another with improved cross-species reactivity1. Our generative AI approach unlocks an accelerated path to designing therapeutic antibodies against diverse targets.
What influences stakeholders' decision in adopting blockchain-based quality tracking systems in prefabricated construction
Authors: Xu Sheng , Zhou Linfeng , Zou Patrick X.W. 
Published: January 2023

PurposeThe quality liability of prefabricated components (PCs) is a major issue among key stakeholders. The blockchain-based quality tracking systems are supposed to support a more transparent and trusting quality control process. However, many factors affect the stakeholders' willingness toward the adoption of such quality tracking systems. The purpose of this research is to investigate the key factors that influence the stakeholders' adoption decisions toward the application of the quality tracking system in PCs and develop coping strategies.Design/methodology/approachAn evolutionary game model is established that includes the manufacturer, constructor and developer. Four scenarios of equilibriums and the game's evolutionary stable strategies are analyzed, and the corresponding stability conditions are then obtained. Based on the tripartite game model, two representative projects are used as case studies to simulate how different factors affect the stakeholders' decisions.FindingsFirst, trade-offs between cost and benefits were the most prominent factor in the adoption decision-making. Second, the advancement of technologies would compensate for their immaturity. Third, subsidy and penalty provision of the developer and high-level trust both incentivize the stakeholders to adopt the quality tracking systems.Originality/valueThis research investigates the influence of technology, environment and participant related factors on the adoption decisions of the quality tracking system for PCs and discovered that technology maturity and advancement played an essential role. It is expected that the research findings would be of value to policy makers and project management personnel for better quality control of prefabricated construction.
Challenges of industrial revolution 4.0: quantity surveying students' perspectives
Authors: Lim Melissa Li Wen , Wong Shi Yee , Ding Chu Sheng 
Published: January 2023

PurposeThe industrial revolution 4.0 (IR4.0) signifies technological advancements and digitalization. The fragmented and labour-intensive nature of the construction industry inherently possesses difficulties for IR4.0 adoption compared to other industries. This paper aims to investigate the perspectives of quantity surveying students on the challenges of IR4.0 implementation in the construction industry.Design/methodology/approachA questionnaire survey were distributed to a population of 191 quantity surveying students, with 96 valid responses returned. Descriptive statistics and factor analysis were employed to analyse the collected data.FindingsFactor analysis revealed eight components as the key challenges for IR4.0 implementation, which revolved around resistance to change, data security issues, etc.Practical implicationsThe findings could provide a guideline to higher education institutions on certain IR4.0-related areas to be incorporated into the syllabus, in ensuring that the students are equipped with such skills and knowledge, in meeting market demands. The construction stakeholders' could look into the identified challenges for strategizing the organizations in moving towards IR4.0 adoption.Originality/valueTo the best of the authors’ knowledge, this is the first study to investigate quantity surveying students' perspectives on the challenges of IR4.0 implementation in the construction industry by employing factor analysis method. The findings contribute to the body of knowledge in relation to the opinions of a younger generation who has more exposure towards technology on the hindrance of IR4.0 adoption.
Measuring sensitivity to change orders in construction projects using eigenvector centrality and radius of gyration
Authors: Zarghami Seyed Ashkan 
Published: January 2023

PurposeThis paper offers a measure of sensitivity to change orders in the later stage of the construction phase to characterize the distribution of project activities around the time when the project is scheduled to finish.Design/methodology/approachThis paper employs eigenvector centrality to identify the sensitivity of an activity to change orders based on the sensitivity of its neighboring activities. Next, a distance-based measure, called the radius of gyration, is adopted to describe the distribution of project activities around the time when the project is scheduled to finish. Finally, a sensitivity measure, which quantifies the dispersion of project activities from the project finish date, is developed.FindingsTwo real-life construction projects are used to measure the sensitivity to late changes. The results conform to the intuition of sensitivity to late changes and confirm that the negative effects of change orders are amplified when project activities are scheduled to start closer to the finish date.Originality/valueThis paper adds to the literature on change orders in construction projects by developing the first method for quantifying the sensitivity of projects to the issuance of late changes. The proposed method can provide valuable information to project owners and construction managers as they negotiate the pricing of change orders based on their time of occurrence.
Workplace bullying and diffident silence: a moderated mediation model of shame and core self-evaluation
Authors: Krishna Arathi , Soumyaja Devi , Sowmya C.S. 
Published: January 2023

Purpose
Workplace bullying generates various emotions, including shame in the target; these emotions can induce employee silence. However, the role of shame in the relationship between workplace bullying and employee silence, and the individual differences in how victims experience shame and silence, has not yet been explored. The present study aims to fill this gap in the literature, using the effect of shame as a mediator and core self-evaluation (CSE) as a moderator.

Design/methodology/approach
Two thousand faculty members working in different colleges in India were invited to participate in the online survey. The participants were invited to fill in the questionnaire only if they had experienced shame by bullying during the preceding two weeks. Three hundred and twenty faculty members responded to the survey.

Findings
The results showed that shame mediates the relationship between workplace bullying and diffident silence. In addition, CSE moderates the relationship between shame and diffident silence but not the relationship between workplace bullying and shame. That is, diffident silence induced by shame was noted to be weaker for employees with high CSE. Importantly, the study could not find any individual difference in experiencing shame by bullying.

Practical implications
Improved CSE can effectively influence diffident silence through shame, helping the management to recognize workplace bullying.

Originality/value
It is a unique attempt to address diffident silence among Indian academicians, and study the role of targets’ shame and CSE while adopting silence on workplace bullying.