bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beurling-Type Density Criteria for System Identification
Authors: Aubel Céline , Bölcskei Helmut , Vlačić Verner 
Published: July 2023

AbstractThis paper addresses the problem of identifying a linear time-varying (LTV) system characterized by a (possibly infinite) discrete set of delay-Doppler shifts without a lattice (or other “geometry-discretizing”) constraint on the support set. Concretely, we show that a class of such LTV systems is identifiable whenever the upper uniform Beurling density of the delay-Doppler support sets, measured “uniformly over the class”, is strictly less than 1/2. The proof of this result reveals an interesting relation between LTV system identification and interpolation in the Bargmann-Fock space. Moreover, we show that the density condition we obtain is also necessary for classes of systems invariant under time-frequency shifts and closed under a natural topology on the support sets. We furthermore find that identifiability guarantees robust recovery of the delay-Doppler support set, as well as the weights of the individual delay-Doppler shifts, both in the sense of asymptotically vanishing reconstruction error for vanishing measurement error.
Multiple, eruptive epitheloide Hämangiome der Kopfhaut
Authors: Mihalceanu Silvia , Schäfer Sarah , Mentzel Thomas , Toberer Ferdinand 
Published: July 2023

ZusammenfassungDas epitheloide Hämangiom ist eine benigne vaskuläre Neoplasie mit einem charakteristischen histologischen und immunhistochemischen Muster, insbesondere gekennzeichnet durch ein lymphozytäres Entzündungsinfiltrat mit beigemengten Eosinophilen und eine FOS-B-Expression. Die Abklärung der Diagnose ist von besonderem Stellenwert, da differenzialdiagnostisch auch maligne epitheloidzellig differenzierte vaskuläre Tumoren infrage kommen. Wir präsentieren eine Patientin mit multiplen epitheloiden Hämangiomen der Kopfhaut, begleitet von starken Schmerzen und Juckreiz. Die lange Vorgeschichte mit multiplen Therapieversuchen verdeutlicht den oft begrenzten Erfolg der aktuell zur Verfügung stehenden Behandlungsmodalitäten.
Expansivity and Periodicity in Algebraic Subshifts
Authors: Kari Jarkko 
Published: July 2023

AbstractA d-dimensional configuration $$c:\mathbb {Z}^d\longrightarrow A$$

c
:

Z

d

⟶
A

is a coloring of the d-dimensional infinite grid by elements of a finite alphabet $$A\subseteq \mathbb {Z}$$

A
⊆
Z

. The configuration c has an annihilator if a non-trivial linear combination of finitely many translations of c is the zero configuration. Writing c as a d-variate formal power series, the annihilator is conveniently expressed as a d-variate Laurent polynomial f whose formal product with c is the zero power series. More generally, if the formal product is a strongly periodic configuration, we call the polynomial f a periodizer of c. A common annihilator (periodizer) of a set of configurations is called an annihilator (periodizer, respectively) of the set. In particular, we consider annihilators and periodizers of d-dimensional subshifts, that is, sets of configurations defined by disallowing some local patterns. We show that a $$(d-1)$$

(
d
-
1
)

-dimensional linear subspace $$S\subseteq \mathbb {R}^d$$

S
⊆

R

d

is expansive for a subshift if the subshift has a periodizer whose support contains exactly one element of S. As a subshift is known to be finite if all $$(d-1)$$

(
d
-
1
)

-dimensional subspaces are expansive, we obtain a simple necessary condition on the periodizers that guarantees finiteness of a subshift or, equivalently, strong periodicity of a configuration. We provide examples in terms of tilings of $$\mathbb {Z}^d$$

Z

d

by translations of a single tile.
Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma
Authors: Nishi Hidemi , Gotoh Kunihito , Tomimaru Yoshito , Kobayashi Shogo , Sasaki Kazuki , Iwagami Yoshifumi , Yamada Daisaku , Akita Hirofumi , Asaoka Tadafumi , Noda Takehiro , Takahashi Hidenori , Tanemura Masahiro , Doki Yuichiro , Eguchi Hidetoshi 
Published: July 2023

Abstract
Purpose

Although gemcitabine-based chemotherapy is most recommended for pancreatic ductal adenocarcinoma (PDAC), its effectiveness is limited because of drug resistance. Given thalidomide’s anti-tumor effects in solid tumors, we investigated the effect of avadomide, a novel thalidomide analog, on PDAC and explored its anti-tumor mechanisms.

Methods
PDAC cell lines, including gemcitabine-resistant (GR) clones derived from MiaPaCa2 cells, were used to evaluate the effects of avadomide. An annexin V assay, a cell cycle assay, and western blot analysis were performed to explain the mechanism of avadomide as an anti-tumor reagent. Moreover, we investigated the anti-tumor effect on tumor growth using a subcutaneous xenograft murine model.

Results
Avadomide showed anti-tumor effects in human PDAC cell lines. The proportion of apoptotic cells and G0/G1 phase cells after avadomide treatment increased, especially in the GR PDAC clones. Western blot analysis also showed the induction of the apoptotic pathway by inhibiting the NF-κB process and G1 phase cell cycle arrest. The xenograft murine model revealed that the proportion of viable cells in the avadomide-treated group was lower than that in the untreated group.

Conclusion
Our findings suggest that avadomide could be a novel therapeutic option to overcome gemcitabine resistance in patients with PDAC.
Mobile Signaling Peptides: Secret Molecular Messengers with a Mighty Role in Plant Life
Authors: Pandita Deepu , Bhat Javaid Akhter , Wani Shabir Hussain , ElSayed Abdelaleim Ismail , Nawaz Ghazala , Mukherjee Soumya , Reyes Vincent P. , Kumar Anuj , Shen Qiufang , Ganie Showkat Ahmad , Siddique Kadambot H. M. 
Published: July 2023

AbstractAdaptive mechanisms for unfavorable environments have evolved in plants for thousands of generations, primarily in the form of endogenous chemical signals and the coordination of physiological processes. Signaling peptides (SPs) are diverse molecular messengers in various stress responses which have been identified in different plant families. SPs are recognized by the membrane-localized receptors and co-receptors, leading to downstream signaling for various plant responses. Progress in in silico analysis, along with other factors, has increased our understanding of the signaling peptide-mediated regulatory mechanisms underlying the entire plant life cycle. SPs mediate both long-distance (root-to-shoot-to-root) and local cell–cell communication via vascular system to communicate and coordinate with plant organs at distant locations. During abiotic stress, SPs inside plant cells perceive stress signals and transfer information at short and long physiological ranges through the signal transduction pathway, causing stress-responsive gene expression. SPs interact with pathogens and mediate cell-to-cell communication via signaling pathways. There are intriguing relationships between phytohormones and the secondary signaling cascades which are mediated by SPs. During biotic or abiotic stress, different peptides trigger jasmonic acid, ethylene, and ABA signaling, involving several secondary messengers. These messengers mediate the stress response via shared signaling components of ROS, Ca2+, and MAPKs, and they modify the gene expression for different phytohormones. In this review, we highlight current knowledge on the role of signaling peptides in plant adaptation, growth, and development. We aim to analyze the SP-receptor interactions and the significance of crosstalk between a few sample SPs and phytohormones. Potential directions on how scientists can use this information for crop improvement are also suggested.
Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas
Authors: Kaulen Leon D. , Denisova Evgeniya , Hinz Felix , Hai Ling , Friedel Dennis , Henegariu Octavian , Hoffmann Dirk C. , Ito Jakob , Kourtesakis Alexandros , Lehnert Pascal , Doubrovinskaia Sofia , Karschnia Philipp , von Baumgarten Louisa , Kessler Tobias , Baehring Joachim M. , Brors Benedikt , Sahm Felix , Wick Wolfgang 
Published: July 2023

AbstractImmunodeficiency-associated primary CNS lymphoma (PCNSL) represents a distinct clinicopathological entity, which is typically Epstein-Barr virus-positive (EBV+) and carries an inferior prognosis. Genetic alterations that characterize EBV-related CNS lymphomagenesis remain unclear precluding molecular classification and targeted therapies. In this study, a comprehensive genetic analysis of 22 EBV+ PCNSL, therefore, integrated clinical and pathological information with exome and RNA sequencing (RNASeq) data. EBV+ PCNSL with germline controls carried a median of 55 protein-coding single nucleotide variants (SNVs; range 24–217) and 2 insertions/deletions (range 0–22). Genetic landscape was largely shaped by aberrant somatic hypermutation with a median of 41.01% (range 31.79–53.49%) of SNVs mapping to its target motifs. Tumors lacked established SNVs (MYD88, CD79B, PIM1) and copy number variants (CDKN2A, HLA loss) driving EBV− PCNSL. Instead, EBV+ PCNSL were characterized by SOCS1 mutations (26%), predicted to disinhibit JAK/STAT signaling, and mutually exclusive gain-of-function NOTCH pathway SNVs (26%). Copy number gains were enriched on 11q23.3, a locus directly targeted for chromosomal aberrations by EBV, that includes SIK3 known to protect from cytotoxic T-cell responses. Losses covered 5q31.2 (STING), critical for sensing viral DNA, and 17q11 (NF1). Unsupervised clustering of RNASeq data revealed two distinct transcriptional groups, that shared strong expression of CD70 and IL1R2, previously linked to tolerogenic tumor microenvironments. Correspondingly, deconvolution of bulk RNASeq data revealed elevated M2-macrophage, T-regulatory cell, mast cell and monocyte fractions in EBV+ PCNSL. In addition to novel insights into the pathobiology of EBV+ PCNSL, the data provide the rationale for the exploration of targeted therapies including JAK-, NOTCH- and CD70-directed approaches.
Inferior mesenteric artery ligation level in rectal cancer surgery: still no answer—a systematic review and meta-analysis
Authors: Cirocchi Roberto , Marchetti Francesco , Mari Giulio , Bagolini Francesco , Cavaliere Davide , Avenia Stefano , Anania Gabriele , Tebala Giovanni , Donini Annibale , Davies Richard Justin , Fingerhut Abe 
Published: July 2023

Abstract
Objective
The aim of this systematic review and meta-analysis is to summarize the current scientific evidence regarding the impact of the level of inferior mesenteric artery (IMA) ligation on post-operative and oncological outcomes in rectal cancer surgery.

Methods
We conducted a systematic review of the literature up to 06 September 2022. Included were RCTs that compared patients who underwent high (HL) vs. anterior (LL) IMA ligation for resection of rectal cancer. The literature search was performed on Medline/PubMed, Scopus, and the Web of Science without any language restrictions. The primary endpoint was overall anastomotic leakage (AL). Secondary endpoints were oncological outcomes, intraoperative complications, urogenital functional outcomes, and length of hospital stay.

Results
Eleven RCTs (1331 patients) were included. The overall rate of AL was lower in the LL group, but the difference was not statistically significant (RR 1.43, 95% CI 0.95 to 2.96). The overall number of harvested lymph nodes was higher in the LL group, but the difference was not statistically significant (MD 0.93, 95% CI − 2.21 to 0.34). The number of lymph nodes harvested was assessed in 256 patients, and all had a laparoscopic procedure. The number of lymph nodes was higher when LL was associated with lymphadenectomy of the vascular root than when IMA was ligated at its origin, but there the difference was not statistically significant (MD − 0.37, 95% CI − 1.00 to 0.26). Overall survival at 5 years was slightly better in the LL group, but the difference was not statistically significant (RR 0.98, 95% CI 0.93 to 1.05). Disease-free survival at 5 years was higher in the LL group, but the difference was not statistically significant (RR 0.97, 95% CI 0.89 to 1.04).

Conclusions
There is no evidence to support HL or LL according to results in terms of AL or oncologic outcome. Moreover, there is not enough evidence to determine the impact of the level of IMA ligation on functional outcomes. The level of IMA ligation should be chosen case by case based on expected functional and oncological outcomes.
Einsatzbereiche und Grundlagen für die 4. Reinigungsstufe in Österreich
Authors: Schaar Heidemarie , Krampe Jörg , Kreuzinger Norbert 
Published: July 2023

ZusammenfassungDer Kommissionsvorschlag für die kommunale Abwasserrichtlinie schreibt die Implementierung einer 4. Reinigungsstufe vor, wenn bestimmte Kriterien erfüllt sind. Dementsprechend müssen große Kläranlagen (≥ 100.000 EW) sowie Anlagen ≥ 10.000 EW, die in spurenstoffempfindliche Gebiete einleiten, ausgebaut werden, um eine 80 %ige Entfernung, gemittelt über mindestens sechs Indikatorsubstanzen zu erreichen. Schätzungen für Österreich reichen von 93 bis 278 auszurüstende Kläranlagen. 278 ist eine Maximalbetrachtung ohne vorherige Risikobewertung und unter Annahme der neu vorgeschlagenen Umweltqualitätsnormen. Sowohl die Ozonung als auch die Aktivkohlebehandlung sind geeignet, um die Mindestanforderungen zu erreichen. Die spezifischen jährlichen Kosten können anhand einer einfachen Funktion grob abgeschätzt werden und liegen bei 16, 8 und 4 €/EW/a für Anlagen mit 10.000, 50.000 oder 200.000 EWAusbau. Die Wechselwirkung mit anderen EU-Rechtsvorschriften und aktuellen Themen der Abwasserreinigung birgt sowohl Synergien, wie z. B. eine solide Grundlage für die weitere Aufbereitung zur Wasserwiederverwendung für die landwirtschaftliche Bewässerung, als auch Herausforderungen, z. B. für die neu vorgeschlagenen strengeren Umweltqualitätsnormen für per- und polyfluorierte Alkylsubstanzen.
Discussion of a variant of eccentric drives utilizing rolling elements
Authors: Fritsch S. , Landler S. , Otto M. , Vogel-Heuser B. , Zimmermann M. , Stahl K. 
Published: July 2023

AbstractIn this paper a variant of eccentric drives will be described, which uses rolling elements instead of an eccentric gear. These rolling elements are constrained by a concentric carrier allowing for radial movement and are moved by an eccentric crank. They mesh with a gear geometry that translates their radial movement into tangential movement and constrains their position. Multiple offset eccentricities may be used with the same gear to reduce occurring forces. Such a drive may prove easier to manufacture than currently used eccentric drives, but the characteristics are not yet fully researched.The components and the working principle of such a drive will be described, and consistent names for the components will be established in this paper. Using these the movement of the rolling elements and the resulting gear geometry will be mathematically described. The forces on a singular rolling element will be derived. An overview of and comparison with related drive mechanisms will be given to aid in the classification of this drive. Different variations of this drive will be discussed, including the choice of rolling elements, whether to use an external or internal gear, and whether a direction-reversing or non-direction-reversing drive is advantageous.
Gear skiving with minimum twist errors
Authors: Hilligardt Andreas , Schulze Volker 
Published: July 2023

AbstractOver the last 15 years, gear skiving has established itself as a highly productive gear cutting process for the production of internal gears and gears with near interference contours. As with all processes with crossed axes, gear skiving generally results in a pronounced natural twist when gears with lead crowning or other flank modifications are produced. In practical applications, the unintended profile angle changes over the tooth width resulting from the twist leading to unwanted contact patterns and unfavorable NVH behavior. In this work, a contact line-based method for tool profile calculation for gear skiving is developed based on conical-screw gear theory. The relationship between contact line and natural twist errors is worked out. The process and tool design strategies for minimizing the twist are elaborated and finally, an adaptive process kinematics for low-twist error gear skiving is presented.
What impacts learning effectiveness of a mobile learning app focused on first-year students?
Authors: Johannsen Florian , Knipp Martin , Loy Thomas , Mirbabaie Milad , Möllmann Nicholas R. J. , Voshaar Johannes , Zimmermann Jochen 
Published: July 2023

AbstractIn recent years, the application of digital technologies for learning purposes is increasingly discussed as smartphones have become an integral part of students’ everyday life. These technologies are particularly promising in the so-called “transition-in” phase of the student lifecycle when first-year students start to develop a student identity and integrate into the university environment. At that stage, most premature dropouts are observed, presumably due to a lack of self-organization or self-responsibility. Considering this, a mobile app to tackle insufficient student experiences, support learning strategies, and foster self-organization in the “transition-in” phase was developed. The research at hand proposes a generalizable success model for mobile apps with a focus on first-year students, which is based on theIS success model(Delone and McLean in Inf Syst Res 3(1):60–95, 1992) and analyzes those factors that influence student satisfaction with such an app, the intention to reuse the app, and—foremost—students’ learning effectiveness. The results indicate that learning effectiveness is determined both by the perceived user satisfaction and users’ intention to reuse, which are particularly influenced by perceived enjoyment but also system and information quality. Finally, design principles are derived to develop similar mobile solutions.
Quantifying quality of class-conditional generative models in time series domain
Authors: Koochali Alireza , Walch Maria , Thota Sankrutyayan , Schichtel Peter , Dengel Andreas , Ahmed Sheraz 
Published: July 2023

AbstractDespite recent breakthroughs in the domain of implicit generative models, the task of evaluating these models remains a challenging task. With no single metric to assess overall performance, various existing metrics only offer partial information. This issue is further compounded for unintuitive data types such as time series, where manual inspection is infeasible. This deficiency hinders the confident application of modern implicit generative models on time series data. To alleviate this problem, we propose two new metrics, the InceptionTime Score (ITS) and the Fréchet InceptionTime Distance (FITD), to assess the quality of class-conditional generative models on time series data. We conduct extensive experiments on 80 different datasets to study the discriminative capabilities of proposed metrics alongside two existing evaluation metrics: Train on Synthetic Test on Real (TSTR) and Train on Real Test on Synthetic (TRTS). Our evaluations reveal that the proposed assessment evaluation metrics, i.e., ITS and FITD in combination with TSTR, can accurately assess class-conditional generative model performance and detect common issues in implicit generative models. Our findings suggest that the proposed evaluation framework can be a valuable tool for confidently applying modern implicit generative models in time series analysis.
Experimental Investigation into the Drag Performance of Chevron-Shaped Protrusions in Wall-Bounded Turbulence
Authors: Carrasco Grau Julio , van Campenhout Olaf W. G. , Hartog Friso H. , van Nesselrooij Michiel , Baars Woutijn J. , Schrijer Ferdinand F. J. 
Published: July 2023

AbstractChevron-shaped protrusions have been proposed in the literature for turbulent skin friction reduction. However, there is no consensus on the performance of this passive flow control technique; both an increase and a decrease in drag have been observed in previous studies. There is also no experimental evidence to support the working mechanism behind the drag reduction effect that has been postulated in the literature. In this study, direct force measurements were used to replicate experiments from the literature and, in addition, were used to test new array configurations to characterise the effect of individual design parameters on drag performance. A total of 23 different protrusion configurations were investigated in a turbulent boundary layer flow. In addition to the integral force measurements, particle image velocimetry was used to measure wall-parallel velocity fields in order to extract the statistical sizing and energy of the near-wall cycle turbulence. All configurations increased the drag between 2% and 10% for a friction Reynolds number of 1700. The drag reduction reported in the literature could not be replicated; however, these findings agreed with an experimental and numerical study that reported drag increase. The trend observed in the low-speed streak spacing from the PIV experiments was consistent with that observed in the balance data. Nevertheless, no evidence was found to support the working mechanism proposed in the literature. These results cast doubt on the proposed drag reduction potential of chevron-shaped protrusions. In the authors’ view, the results of this study strengthen previous conclusions regarding their minor increase in drag. Future studies to further approach a consensus are proposed.
Electrohydrodynamic convection instabilities observed in suspensions of cellulose nanocrystals
Authors: Frka-Petesic Bruno , Jean Bruno , Heux Laurent 
Published: July 2023

AbstractCellulose nanocrystals are slender, negatively charged nanoparticles that spontaneously form a cholesteric liquid crystal in aqueous suspension above a critical concentration. When they are suspended in apolar solvents such as toluene using surfactants, the application of an AC electric field leads to the reorientation and then distortion of the cholesteric order until the cholesteric structure completely unwinds into a nematic-like order, typically above 0.4–0.6 kV/cm at 1kHz. In this work, we show that at much higher electric fields ($$\ge$$
≥
4.6 kV/cm at 1 kHz) the sample develops a periodic pattern that varies with the field amplitude. We ascribed this pattern to electrohydrodynamic convection instabilities. These instabilities usually present complex regimes varying with the field, the voltage, the frequency and the geometry. However, the typical geometry where these instabilities were most documented across the literature differs from the geometry used in this work. This work concludes with possible future experimental investigations to clarify the exact regime of instability responsible for these observations.