bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between metabolically healthy overweight/obesity and gallstones in Chinese adults
Authors: Zhang Junlu , Chen Liangli , Shen Keqing , Zhang Jia , Zhu Yue , Qiao Qiaohua , Chen Liying 
Published: March 2023

Abstract
Background
Metabolic syndrome and obesity are risk factors for gallstones. However, these two factors often occur together, and few studies have focused on the association between metabolically healthy overweight/obesity (MHOW/MHO) and gallstones. We hypothesized that MHO individuals would be associated with the prevalence of gallstones.

Methods
This cross-sectional study included 125,668 participants aged 18–80 years at the Health Promotion Center of Run Run Run Shaw Hospital, Zhejiang University School of Medicine during 2017–2019 years. Each participant underwent a comprehensive health checkup. Gallstones were diagnosed by abdominal ultrasonography. Metabolically health was defined as not meeting the diagnostic criteria for metabolic syndrome (MetS). Obesity was measured by BMI. MetS and weight stratification were combined to classify the metabolism-obesity phenotypes. Logistic regression models were used to estimate adjusted odds ratios (ORs) and 95% CIs.

Results
Among 125,668 participants, 5486 (4.4%) had gallstones. 21407 (17.0%) were MHOW individuals, and 3322 (2.6%) were MHO individuals. MHOW (OR 1.40; 95%CI: 1.29–1.53) and MHO (OR 1.80; 95%CI: 1.53–2.12) participants were at higher risk of gallstones and had larger and more numerous gallstones than metabolically healthy normal weight participants. Obesity, MetS, premenopausal women and advanced age were significantly associated with the prevalence of gallstones.

Conclusions
MHOW/MHO individuals exhibited a higher risk of gallstones. In metabolically healthy individuals, the risk of gallstones increased with increasing BMI. Thus, obesity was associated with the prevalence of gallstones, even in relatively metabolically healthy adults.
qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data
Authors: Queme Bryan , Braisted John C. , Dranchak Patricia , Inglese James 
Published: March 2023

AbstractHigh throughput screening (HTS) is widely used in drug discovery and chemical biology to identify and characterize agents having pharmacologic properties often by evaluation of large chemical libraries. Standard HTS data can be simply plotted as an x–y graph usually represented as % activity of a compound tested at a single concentration vs compound ID, whereas quantitative HTS (qHTS) data incorporates a third axis represented by concentration. By virtue of the additional data points arising from the compound titration and the incorporation of logistic fit parameters that define the concentration–response curve, such as EC50 and Hill slope, qHTS data has been challenging to display on a single graph. Here we provide a flexible solution to the rapid plotting of complete qHTS data sets to produce a 3-axis plot we call qHTS Waterfall Plots. The software described here can be generally applied to any 3-axis dataset and is available as both an R package and an R shiny application.Graphical Abstract
A blockchain-based SLA monitoring and compliance assessment for IoT ecosystems
Authors: Alzubaidi Ali , Mitra Karan , Solaiman Ellis 
Published: March 2023

AbstractA Service Level Agreement (SLA) establishes the trustworthiness of service providers and consumers in several domains; including the Internet of Things (IoT). Given the proliferation of Blockchain technology, we find it compelling to reconsider the assumption of trust and centralised governance typically practised in SLA management including monitoring, compliance assessment, and penalty enforcement. Therefore, we argue that, such critical tasks should be operated by blockchain-based smart contracts in a non-repudiable manner beyond the influence of any SLA party. This paper envisions an IoT scenario wherein a firefighting station outsources end-to-end IoT operations to a specialised service provider. The contractual relationship between them is governed by an SLA which stipulates a set of quality requirements and violation consequences. The main contribution of this paper lies in designing, deploying and empirically experimenting a novel blockchain-based SLA monitoring and compliance assessment framework in the context of IoT. This is done by utilising Hyperledger Fabric (HLF), an enterprise-grade blockchain technology. Our work highlights a set of considerations and best practice at two sides, the IoT application monitoring-side and the blockchain-side. Moreover, it experimentally validates the reliability of the proposed monitoring approach, which collects relevant metrics from each IoT component and examines them against the quality requirements stated in the SLA. Finally, we propose a novel design for smart contracts at the blockchain-side, analyse and benchmark the performance, and demonstrate that the new design proves to successfully handle Multiversion Concurrency Control (MVCC) conflicts typically encountered in blockchain applications, while maintaining sound throughput and latency.
Strategies to improve outcomes of youth experiencing healthcare transition from pediatric to adult HIV care in a large U.S. city
Authors: Momplaisir Florence , McGlonn Kassandra , Grabill Megan , Moahi Kaelo , Nkwihoreze Hervette , Knowles Kayla , Laguerre Roberta , Dowshen Nadia , Hussen Sophia A. , Tanner Amanda E. , Lowenthal Elizabeth D. 
Published: March 2023

Abstract
Background
The healthcare transition (HCT) from pediatric to adult HIV care can be disruptive to HIV care engagement and viral suppression for youth living with HIV (YLH).

Methods
We performed qualitative interviews with 20 YLH who experienced HCT and with 20 multidisciplinary pediatric and adult HIV clinicians to assess and rank barriers and facilitators to HCT and obtain their perspectives on strategies to improve the HCT process. We used the Exploration Preparation Implementation Sustainment Framework to guide this qualitative inquiry.

Results
The most impactful barriers identified by YLH and clinicians focused on issues affecting the patient-clinician relationship, including building trust, and accessibility of clinicians. Both groups reported that having to leave the pediatric team was a significant barrier (ranked #1 for clinicians and #2 for YLH). The most impactful facilitator included having a social worker or case manager to navigate the HCT (listed #1 by clinicians and #2 by YLH); case managers were also identified as the individual most suited to support HCT. While YLH reported difficulty building trust with their new clinician as their #1 barrier, they also ranked the trust they ultimately built with a new clinician as their #1 facilitator. Factors reported to bridge pediatric and adult care included providing a warm handoff, medical record transfer, developing relationships between pediatric clinics and a network of youth-friendly adult clinics, and having the pediatric case manager attend the first adult appointment. Longer new patient visits, increased health communication between YLH and clinicians and sharing vetted clinician profiles with YLH were identified as innovative strategies.

Conclusion
In this multi-disciplinary contextual inquiry, we have identified several determinants that may be targeted to improve HCT for YLH.
Psychological distress is more common in some occupations and increases with job tenure: a thirty-seven year panel study in the United States
Authors: Laditka James N. , Laditka Sarah B. , Arif Ahmed A. , Adeyemi Oluwaseun J. 
Published: March 2023

Abstract
Background
Workers in certain occupations may have elevated risks of psychological distress. However, research is limited. For example, researchers often measure distress that may have existed before occupational exposures. We studied occupations and the development of psychological distress using national data from the United States.

Methods
We reviewed relevant research to identify occupations with low and high risks of mental health problems. We confirmed those individual low and high risk occupations using 1981–2017 data from the Panel Study of Income Dynamics (n = 24,789). We measured new cases of distress using the Screening Scale for Psychological Distress (Kessler K6) and compared distress in the low and high risk groups, adjusted for factors associated with occupational selection and non-occupational distress risks. A subset of participants described their jobs (n = 1,484), including factors such as job demands, social support, and control over work. We examined associations of those factors with psychological distress.

Results
Workers in high risk occupations had 20% higher adjusted odds of developing distress than those in low risk occupations (odds ratio, OR 1.20, 95% confidence interval, CI 1.13–1.28). Distress increased with time in a high risk occupation: ≥5 years OR 1.38 (CI 1.18–1.62), ≥ 10 years OR 1.46 (CI 1.07–1.99), and ≥ 15 years OR 1.77 (CI 1.08–2.90; p-trend = 0.0145). The most common positive participant descriptions of their jobs indicated social support (34%), sense of accomplishment (17%), and control over work (15%). Participants reporting such descriptions were significantly less likely to have a high risk occupation (OR 0.66, CI 0.46–0.94, p = 0.0195). The most common negative descriptions were excessive job demands (43%), low social support (27%), and lack of control (14%). Participants reporting such descriptions were significantly more likely to have a high risk occupation (OR 1.49, CI 1.03–2.14, p = 0.0331).

Conclusion
Certain occupations may have high risks of psychological distress, which may be due to characteristics of the occupations rather than employee characteristics, or in addition to them. Results were consistent with theoretical models of psychosocial work environments. Providers of health care and social services should ask patients or clients about work-related distress.
Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease
Authors: Carrero Laura , Antequera Desireé , Alcalde Ignacio , Megías Diego , Figueiro-Silva Joana , Merayo-Lloves Jesús , Municio Cristina , Carro Eva 
Published: March 2023

AbstractThe circadian clock is synchronized to the 24 h day by environmental light which is transmitted from the retina to the suprachiasmatic nucleus (SCN) primarily via the retinohypothalamic tract (RHT). Circadian rhythm abnormalities have been reported in neurodegenerative disorders such as Alzheimer's disease (AD). Whether these AD-related changes are a result of the altered clock gene expression, retina degeneration, including the dysfunction in RHT transmission, loss of retinal ganglion cells and its electrophysiological capabilities, or a combination of all of these pathological mechanisms, is not known. Here, we evaluated transgenic APP/PS1 mouse model of AD and wild-type mice at 6- and 12-month-old, as early and late pathological stage, respectively. We noticed the alteration of circadian clock gene expression not only in the hypothalamus but also in two extra-hypothalamic brain regions, cerebral cortex and hippocampus, in APP/PS1 mice. These alterations were observed in 6-month-old transgenic mice and were exacerbated at 12 months of age. This could be explained by the reduced RHT projections in the SCN of APP/PS1 mice, correlating with downregulation of hypothalamic GABAergic response in APP/PS1 mice in advanced stage of pathology. Importantly, we also report retinal degeneration in APP/PS1 mice, including Aβ deposits and reduced choline acetyltransferase levels, loss of melanopsin retinal ganglion cells and functional integrity mainly of inner retina layers. Our findings support the theory that retinal degeneration constitutes an early pathological event that directly affects the control of circadian rhythm in AD.
Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain
Authors: Wang Wenzhang , Zhao Fanpeng , Lu Yubing , Siedlak Sandra L. , Fujioka Hisashi , Feng Hao , Perry George , Zhu Xiongwei 
Published: March 2023

AbstractLoss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying mechanism remains incompletely understood. Synaptic terminals have abundant mitochondria which play an indispensable role in synaptic function through ATP provision and calcium buffering. Mitochondrial dysfunction is an early and prominent feature in AD which could contribute to synaptic deficits. Here, using electron microscopy, we examined synapses with a focus on mitochondrial deficits in presynaptic axonal terminals and dendritic spines in cortical biopsy samples from clinically diagnosed AD and age-matched non-AD control patients. Synaptic vesicle density within the presynaptic axon terminals was significantly decreased in AD cases which appeared largely due to significantly decreased reserve pool, but there were significantly more presynaptic axons containing enlarged synaptic vesicles or dense core vesicles in AD. Importantly, there was reduced number of mitochondria along with significantly increased damaged mitochondria in the presynapse of AD which correlated with changes in SV density. Mitochondria in the post-synaptic dendritic spines were also enlarged and damaged in the AD biopsy samples. This study provided evidence of presynaptic vesicle loss as synaptic deficits in AD and suggested that mitochondrial dysfunction in both pre- and post-synaptic compartments contribute to synaptic deficits in AD.
Impact of popular beverages on polyamides versus polymethyl methacrylate denture base materials colour stability: in vitro study
Authors: Mostafa Marwa Hassan , Abuhelal Osama Abdel-hamid , AlSourori Ali Abdulghani 
Published: March 2023

Abstract
Background
Changing of different denture base materials colours could have a detrimental impact on patients' satisfaction and make them seek more frequent adjustments to their prosthesis; hence this study was conducted to investigate the colour stability of the conventional denture base polymer (PMMA) and polyamides.

Methods
Specimens of conventional PMMA and thermoplastic polyamides were constructed according to manufacturer instructions and utilized during the current study. For colour stability test a total of 80 specimens with dimensions of 40 mm (length) X 20 mm (width) X 0.8 mm (thicknesses), the specimens in this test were divided into two equal groups (n = 40) (PMMA specimens and polyamides specimens).

Results
When compared to polymethyl methacrylate denture base resin, polyamid denture base resin exhibited the greatest colour change (P 0.001). For 7 and 30 days, both materials had the greatest value in tea solution. One-Way ANOVA test P < 0.00001).

Conclusions
Within limitation of this in vitro study, we found that heat-cure PMMA resin has the significant higher colour stability when compared to the Polyamides after immersion in the tea, cola, coffee and distilled water solutions for 30 days.
Regional citrate anticoagulation (RCA) in critically ill patients undergoing renal replacement therapy (RRT): expert opinion from the SIAARTI-SIN joint commission
Authors: Pistolesi Valentina , Morabito Santo , Pota Vincenzo , Valente Fabrizio , Di Mario Francesca , Fiaccadori Enrico , Grasselli Giacomo , Brienza Nicola , Cantaluppi Vincenzo , De Rosa Silvia , Fanelli Vito , Fiorentino Marco , Marengo Marita , Romagnoli Stefano ,   the SIAARTI-SIN joint commission
Published: March 2023

AbstractRenal replacement therapies (RRT) are essential to support critically ill patients with severe acute kidney injury (AKI), providing control of solutes, fluid balance and acid–base status. To maintain the patency of the extracorporeal circuit, minimizing downtime periods and blood losses due to filter clotting, an effective anticoagulation strategy is required.Regional citrate anticoagulation (RCA) has been introduced in clinical practice for continuous RRT (CRRT) in the early 1990s and has had a progressively wider acceptance in parallel to the development of simplified systems and safe protocols. Main guidelines on AKI support the use of RCA as the first line anticoagulation strategy during CRRT in patients without contraindications to citrate and regardless of the patient’s bleeding risk.Experts from the SIAARTI-SIN joint commission have prepared this position statement which discusses the use of RCA in different RRT modalities also in combination with other extracorporeal organ support systems. Furthermore, advise is provided on potential limitations to the use of RCA in high-risk patients with particular attention to the need for a rigorous monitoring in complex clinical settings. Finally, the main findings about the prospective of optimization of RRT solutions aimed at preventing electrolyte derangements during RCA are discussed in detail.
Microsurgery Versus Stereotactic Radiosurgery for Treatment of Patients With Brain Arteriovenous Malformation: A Systematic Review and Meta-Analysis
Authors: Sattari Shahab Aldin , Shahbandi Ataollah , Kim Jennifer E. , Lee Ryan P. , Feghali James , Hung Alice , Yang Wuyang , Rincon-Torroella Jordina , Xu Risheng , Caplan Justin M. , Gonzalez L. Fernando , Tamargo Rafael J. , Huang Judy 
Published: March 2023

BACKGROUND:
Treatment decision-making for brain arteriovenous malformations (bAVMs) with microsurgery or stereotactic radiosurgery (SRS) is controversial.

OBJECTIVE:
To conduct a systematic review and meta-analysis to compare microsurgery vs SRS for bAVMs.

METHOD:
Medline and PubMed were searched from inception to June 21, 2022. The primary outcomes were obliteration and follow-up hemorrhage, and secondary outcomes were permanent neurological deficit, worsened modified Rankin scale (mRS), follow-up mRS > 2, and mortality. The GRADE approach was used for grading the level of evidence.

RESULTS:
Eight studies were included, which yielded 817 patients, of which 432 (52.8%) and 385 (47.1%) patients underwent microsurgery and SRS, respectively. Two cohorts were comparable in age, sex, Spetzler-Martin grade, nidus size, location, deep venous drainage, eloquence, and follow-up. In the microsurgery group, the odds ratio (OR) of obliteration was higher (OR = 18.51 [11.05, 31.01], P < .000001, evidence: high) and the hazard ratio of follow-up hemorrhage was lower (hazard ratio = 0.47 [0.23, 0.97], P = .04, evidence: moderate). The OR of permanent neurological deficit was higher with microsurgery (OR = 2.85 [1.63, 4.97], P = .0002, evidence: low), whereas the OR of worsened mRS (OR = 1.24 [0.65, 2.38], P = .52, evidence: moderate), follow-up mRS > 2 (OR = 0.78 [0.36, 1.7], P = .53, evidence: moderate), and mortality (OR = 1.17 [0.41, 3.3], P = .77, evidence: moderate) were comparable between the groups.

CONCLUSION:
Microsurgery was superior at obliterating bAVMs and preventing further hemorrhage. Despite a higher rate of postoperative neurological deficit with microsurgery, functional status and mortality were comparable with patients who underwent SRS. Microsurgery should remain a first-line consideration for bAVMs, with SRS reserved for inaccessible locations, highly eloquent areas, and medically high-risk or unwilling patients.
A Validation Study of Four Preoperative Surgical Planning Tools for Adult Spinal Deformity Surgery in Proximal Junctional Kyphosis and Clinical Outcomes
Authors: Park Se-Jun , Lee Chong-Suh , Park Jin-Sung , Jeon Chung-Youb , Ma Chang-Hyun 
Published: March 2023

BACKGROUND:
Four guidelines have been suggested for optimal correction in adult spinal deformity surgery: Scoliosis Research Society (SRS)-Schwab classification, age-adjusted sagittal alignment goals, Global Alignment and Proportion (GAP) score, and the Roussouly algorithm. Whether these goals provide benefit in both proximal junctional kyphosis (PJK) reduction and clinical outcome improvement remains unclear.

OBJECTIVE:
To validate 4 preoperative surgical planning tools in PJK development and clinical outcomes.

METHODS:
We retrospectively reviewed patients who underwent ≥5-segment fusion including the sacrum for adult spinal deformity with a follow-up of ≥2-year. PJK development and clinical outcomes were compared among the groups separately using 4 surgical guidelines: SRS-Schwab pelvic incidence (PI)-lumbar lordosis (LL) modifier (Group 0, +, ++), age-adjusted PI-LL goal (undercorrection, matched correction, and overcorrection), GAP score (proportioned, moderately disproportioned, and severely disproportioned groups), and the Roussouly algorithm (restored and nonrestored groups).

RESULTS:
A total of 189 patients were included in this study. The mean age was 68.3 years, and there were 162 women (85.7%). There were no differences in the rate of PJK development and clinical outcomes among SRS-Schwab PI-LL modifier and GAP score groups. With the age-adjusted PI-LL goal, PJK developed significantly less frequently in the matched group compared with the under- and overcorrection groups. Clinical outcomes were significantly better in the matched group compared with the under- and overcorrection groups. With the Roussouly algorithm, PJK developed significantly less frequently in the restored group than in the nonrestored group. However, there were no differences in clinical outcomes between the 2 Roussouly groups.

CONCLUSION:
Correction according to the age-adjusted PI-LL goal and the restored Roussouly type was associated with reduced PJK development. However, differences in clinical outcomes were only observed in the age-adjusted PI-LL groups.
Bleeding Risk of Cerebral Cavernous Malformations in Patients on Statin and Antiplatelet Medication: A Cohort Study
Authors: Marques Luca Lee , Jaeggi Christian , Branca Mattia , Raabe Andreas , Bervini David , Goldberg Johannes 
Published: March 2023

BACKGROUND:
Statin medication has been identified as a potential therapeutic target for stabilizing cerebral cavernous malformations (CCMs). Although increasing evidence suggests that antiplatelet medication decreases the risk of CCM hemorrhage, data on statin medication in clinical studies are scarce.

OBJECTIVE:
To assess the risk of symptomatic CCM-related hemorrhage at presentation and during follow-up in patients on statin and antiplatelet medication.

METHODS:
A single-center database containing patients harboring CCMs was retrospectively analyzed over 41 years and interrogated for symptomatic hemorrhage at diagnosis, during follow-up, and statin and antiplatelet medication.

RESULTS:
In total, 212 of 933 CCMs (22.7%), harbored by 688 patients, presented with hemorrhage at diagnosis. Statin medication was not associated with a decreased risk of hemorrhage at diagnosis (odds ratio [OR] 0.63, CI 0.23-1.69, P = .355); antiplatelet medication (OR 0.26, CI 0.08-0.86, P = .028) and combined statin and antiplatelet medication (OR 0.19, CI 0.05-0.66; P = .009) showed a decreased risk. In the antiplatelet-only group, 2 (4.7%) of 43 CCMs developed follow-up hemorrhage during 137.1 lesion-years compared with 67 (9.5%) of 703 CCMs during 3228.1 lesion-years in the nonmedication group. No follow-up hemorrhages occurred in the statin and the combined statin and antiplatelet medication group. Antiplatelet medication was not associated with follow-up hemorrhage (hazard ratio [HR] 0.7, CI 0.16-3.05; P = .634).

CONCLUSION:
Antiplatelet medication alone and its combination with statins were associated with a lower risk of hemorrhage at CCM diagnosis. The risk reduction of combined statin and antiplatelet medication was greater than in patients receiving antiplatelet medication alone, indicating a possible synergistic effect. Antiplatelet medication alone was not associated with follow-up hemorrhage.