bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field study of the fire‐blight‐resistant cisgenic apple line C44.4.146
Authors: Schlathölter Ina , Broggini Giovanni A. L. , Streb Sebastian , Studer Bruno , Patocchi Andrea 
Published: January 2023

SUMMARYCisgenesis, the genetic modification of a plant with genes from a sexually compatible plant, was used to confer fire blight resistance to the cultivar ‘Gala Galaxy’ by amendment of the resistance gene FB_MR5, resulting in the line C44.4.146. To verify whether cisgenesis changed other tree‐, flower‐ or fruit‐related traits, a 5‐year field trial was conducted with trees of C44.4.146 and multiple control genotypes, including members of the ‘Gala’ sports group. None of the 44 investigated tree‐, flower‐ or fruit‐related traits significantly differed between C44.4.146 and at least one of the control genotypes in all observation years. However, fruits of C44.4.146 and its wild‐type ‘Gala Galaxy’ from tissue culture were paler in color than fruits of ‘Gala Galaxy’ that had not undergone tissue culture. There was no significant and consistently detected difference in the fruit flesh and peel metabolome of C44.4.146 compared with the control genotypes. Finally, the disease resistance of C44.4.146 was confirmed also when the fire blight pathogen was inoculated through the flowers. We conclude that the use of cisgenesis to confer fire blight resistance to ‘Gala Galaxy’ in C44.4.146 did not have unintended effects, and that the in vitro establishment of ‘Gala Galaxy’ had a greater effect on C44.4.146 properties than its generation applying cisgenesis.
Habitat quality–physicochemical water quality–littoral macroinvertebrate community nexus in Lugo Lake (Ethiopia): Priorities for sustainable water resources management
Authors: Woretaw Lebasie , Dagne Mengesha , Gizeyatu Adinew , Daba Chala , Atamo Amanuel , Sewunet Birhanu , Debela Sisay Abebe , Birara Amualaw , Gebrehiwot Mesfin 
Published: January 2023

AbstractThe integration of water quality characteristics with habplot‐based habitat quality assessment score (HabQA) has received little attention in ecological quality assessment studies. This study investigated the macroinvertebrate community structure in relation with lake habitat quality and physicochemical water quality variables in Lugo Lake (Ethiopia). Twelve sampling sites (eight agricultural and four recreational) were included. The variation among macroinvertebrates data was significantly explained by HabQA score and soluble reactive phosphorus. The study revealed the greater importance of habitat quality characteristics in comparison with the other conventional physicochemical characteristics on macroinvertebrate community structure. We strongly recommend the use of HabQA system while studying macroinvertebrate community structure for a deeper understanding of the environmental functioning of tropical lakes. The results suggested the need to apply integrated and sustainable protection and management of the lake catchment (including wetlands) to enhance the ecological integrity and hence biodiversity of lakes.
Palygorskite–TiO2 nanocatalysts for photocatalytic degradation of tebuconazole in water
Authors: Gianni Eleni , Panagiotaras Dionisios , Giannakis Ioannis , Papoulis Dimitrios , Bekiari Vlasoula , Panagopoulos Georgios , Petrounias Petros , Kalarakis Alexandros 
Published: January 2023

AbstractPalygorskite–TiO2 nanoparticles are frequently used as nanocatalysts. In the present study, two different nanocatalysts were developed based on the use of different palygorskite–TiO2 ratios: 40–60 and 10–90. The nanocomposites were investigated for the photocatalytic degradation of the common fungicide tebuconazole (TEB), under aquatic conditions. The samples were extensively characterized by X‐ray powder diffraction, attenuated total reflectance–Fourier transform infrared spectroscopy, scanning electron microscopy and N2 specific surface area (SSA) by Brunauer–Emmett–Teller (BET) analytical techniques. The TiO2 nanoparticles were successfully dispersed on the mineral's surfaces and the photocatalytic activity reached 88.4% for the palygorskite–TiO2 ratio of 40:60, where the dispersion was better as proved by the total pore volume and BET parameters (0.49 cm3/g and 258 m2/g compared to 0.33 cm3/g and 220 m2/g of the 10:90 ratio). The photocatalytic efficiency of the proposed materials was significantly higher than Degussa P25 (33.2%), and that makes the palygorskite–TiO2 nanocomposites very promising for advanced application in fungicides' degradation in aquatic environments.
Presymplectic BV-AKSZ formulation of conformal gravity
Authors: Dneprov Ivan , Grigoriev Maxim 
Published: January 2023

AbstractWe elaborate on the presymplectic BV-AKSZ approach to local gauge theories and apply it to conformal gravity. More specifically, we identify a compatible presymplectic structure on the minimal model of the total BRST complex of this theory and show that together with the BRST differential it determines a full-scale BV formulation for a specific frame-like action which seems to be previously unknown. Remarkably, the underlying frame-like description requires no artificial off-shell constraints. Instead, the action becomes equivalent to the usual conformal gravity one, upon gauging away all the variables belonging to the kernel of the presymplectic structure. Finally, we show how the presymplectic BV-AKSZ approach extends to generic gauge theories.
The “Unfading Crown of Glory” as Conceptual Key
Authors: Wright John Randolph 
Published: January 2023

Abstract
This article seeks to offer a new reading of 1 Peter, while building upon the work of Barth L. Campbell, Travis B. Williams, and David G. Horrell (and others of course). Campbell sought to elucidate the importance of honor for the audience of 1 Peter utilizing Rhetorical Criticism, while both Williams and Horrell have employed Postcolonial Criticism to provide a reading “from the margins.” Specifically, Williams offered an interpretation of “good works” which situated that semantic and conceptual domain within subaltern strategies of mimicry and symbolic inversion. However, heretofore largely unexplored in 1 Peter is that aspect of the honor equation which actualizes honor: the honorific. This study argues that “the unfading crown of glory” in 1 Pet 5:4 serves as a conceptual key to the subversive honorific language within, thereby actualizing (and subverting) the broader theme of honor through the recognition of “good works.”
Paul, Phoebe, Timothy, and Their Collections for Judea
Authors: Fellows Richard G. 
Published: January 2023

Abstract
Studies of Paul’s collection(s) for Judea have suffered from the largely unexamined assumption that he wanted all regions to donate at the same time. Paul and Phoebe collaborated to organize a collection from Rome, and Paul anticipated a collection from Asia. There was likely a collection from Galatia several years before the collection from Macedonia and Achaia, and there is little reason to doubt the collection from Antioch. The silence of Acts concerning these collections is no argument against them, and it can be explained as a protective measure. We have no evidence that any of the collections were rejected.
Hope and resilience among patients affected by unipolar and bipolar depression
Authors: Favale Donato , Nacci Maria , Bellomo Antonello , Torales Julio , Castaldelli-Maia João Mauricio , Ventriglio Antonio 
Published: January 2023

Background: Mood disorders, including unipolar and bipolar depression, are disabling mental conditions and patients’ full-functional recovery may be challenging. Hope and Resilience are relevant factors in the framework of personal recovery and it is of interest to explore their association with the severity of depressive illness and other variables, including suicidality. Methods: in this cross-sectional study, 69 patients affected by unipolar ( n = 31) and bipolar depression ( n = 38) have been recruited and information about their sociodemographics, clinical characteristics were collected as well as the following assessment has been performed: BPRS (Brief Psychiatric Rating Scale); HAMD ( Hamilton Rating Scale for Depression); MADRS (Montgomery Asberg Depression rating scale); HADS ( Hospital Anxiety and Depression Scale); SSI (Scale for Suicide Ideation); Synder (The Adult Hope Scale); CD-Risk (The Connor-Davidson Resilience Scale). Results: patients affected by bipolar depression reported significantly higher level of psychopathological issues (BPRS) as well as higher scores of depressive and anxious symptoms (MADRS and HADS), suicidality (SSI). Also, bipolar depression patients reported lower levels of hope (Synder) and resilience (CD-Risk), with hope and resilience levels positively correlated each other, and inversely correlated to psychopathology and psychopathology, depressive and suicidal symptoms, respectively. Conclusions: these findings suggested that bipolar depression is characterized by higher clinical severity and lower levels of hope and resilience. Specific psycho-educational and psychotherapeutic interventions should be promoted to increase levels of hope and resilience in mood disorders, especially in bipolar depression.
Selecting appropriate compression for lymphedema patients: American Vein and Lymphatic Society position statement
Authors: Hettrick Heather , Ehmann Suzie , McKeown Brandy , Bender Dean , Blebea John 
Published: January 2023

Background Lymphedema is a significant and disabling disorder affecting millions of people worldwide. Compression therapy is an important component of lifelong treatment but the specifics of appropriate compression garment selection and prescribing is not always well understood by practitioners and payers. Method An expert panel of the American Vein and Lymphatic Society was convened to write a Position Statement with explanations and recommendations for the appropriate compression therapy to be used in the treatment of lymphedema patients. Result A Position Statement was produced by the expert panel with recommendations for documentation and compression therapy treatment. Their recommendations were reviewed, edited, and approved by the Guidelines Committee of the society. Conclusion This societal Position Statement provides a useful document for reference for medical care providers for the appropriate compression therapy selection and treatment of patients with lymphedema.
TK-1, TP, Ang-2, and Tie-2 mRNA expression in plasma-derived microvesicles of chemo-refractory metastatic colorectal cancer patients
Authors: Borelli Beatrice , Crucitta Stefania , Boccaccino Alessandra , Antista Maria , Antoniotti Carlotta , Marmorino Federica , Rossini Daniele , Conca Veronica , Germani Marco Maria , Provenzano Leonardo , Spagnoletti Andrea , Leone Alberto Giovanni , Cucchiara Federico , Pietrantonio Filippo , Del Re Marzia , Danesi Romano , Masi Gianluca , Cremolini Chiara , Moretto Roberto 
Published: January 2023

Background: Trifluridine/tipiracil and regorafenib are indicated for metastatic colorectal cancer (mCRC) patients’ refractory to standard chemotherapy. No prognostic or predictive biomarkers are available for these agents. Methods: We assessed messenger ribonucleic acid (mRNA) expression of four biomarkers implicated in the mechanism of action of trifluridine/tipiracil (TK-1 and TP) and regorafenib (Ang-2 and Tie-2) in baseline plasma-derived microvesicles of chemo-refractory mCRC patients treated with these agents (trifluridine/tipiracil cohort and regorafenib cohort), to explore their prognostic and predictive role. Results: Baseline characteristics of the two cohorts were not different. Ang-2 mRNA was not detectable. Only TK-1 expression measured as a continuous variable was associated with progression-free survival (HR=1.09, 95%CI: 0.99-1.21; p=0.07) and overall survival (HR=1.11, 95%CI: 1.00-1.22; p=0.04), confirmed at multivariate analysis for progression-free survival (p=0.02) with a positive trend for overall survival (p=0.08). Baseline mRNA levels of TK-1, TP and Tie-2 were not predictive of trifluridine/tipiracil and regorafenib benefit. Conclusion: Baseline mRNA levels of TK-1, TP and Tie-2 on plasma-derived microvesicles were not predictive of trifluridine/tipiracil and regorafenib benefit. Future studies should analyze the early modulation of these biomarkers to assess their potential predictive role.
Single Use or Disposable Flexible Bronchoscopes: Bench Top and Preclinical Comparison of Currently Available Devices
Authors: Deasy Kevin Frederick , Sweeney Anne-Marie , Danish Hammad , O’Reilly Emily , Ibrahim Hisham , Kennedy Marcus Peter 
Published: January 2023

Background Data regarding the risk of infection related to reusable bronchoscopes, the global drive toward disposable technology and the COVID-19 pandemic have led to an increase in the use and production of single use or disposable bronchoscopes. An in-depth comparison of all available devices has not been published. Methods A benchtop comparison of the Ambu®aScopeTM, Boston Scientific® EXALTTM Model B, the Surgical Company Broncoflex© Vortex, Pentax® Medical ONE Pulmo™, and Vathin® H-SteriscopeTM (all 2.8 mm inner dimension other than the Pentax single-use flexible bronchoscope (3 mm)) was undertaken including measurement of maximal flexion and extension angles, thumb force required and suction with and without biopsy forceps. Thereafter, preclinical assessment was performed with data collected including experience, gender, hand size, and scope preference. Results The Vathin single-use flexible bronchoscope had the biggest range of tip movement from flexion to extension with and without forceps. The Boston single-use flexible bronchoscope required the maximal thumb force but had the least reduction of tip movement with forceps. The Boston single-use flexible bronchoscope significantly outperformed all other scopes including the standard Pentax scope and was the only scope capable of suctioning pseudo-mucus around the forceps. Although there was no significant difference in preference in the overall group, females and those with smaller hand size preferred the Pentax and males the Broncoflex single-use flexible bronchoscope. Conclusions Currently available single-use flexible bronchoscopes differ in several factors other than scope sizes and monitor including suction, turning envelope, and handle size. Performance in the clinical setting will be key to their success.
Factors related to COVID-19 vaccine hesitancy in Denmark: A national study in the autumn of 2021
Authors: Rosenkilde Siri , Ekholm Ola , Møller Sanne P. , Nielsen Maj Britt D. , Thygesen Lau C. 
Published: January 2023

Aims: The novelty of the COVID-19 pandemic and fast-developed vaccines may increase concerns about the safety and effectiveness of the COVID-19 vaccine and thereby influence vaccine hesitancy. The aims of this study were to examine (a) the main reasons for COVID-19 vaccine hesitancy and (b) factors associated with COVID-19 vaccine hesitancy. Methods: A nationwide survey was conducted in the autumn of 2021 when most Danes had received at least one dose of a COVID-19 vaccine. The sample ( N=13,570) was based on a random selection of individuals (⩾15 years), and data were collected via self-administered mailed questionnaires (digital and physical). The participants were asked whether they had been vaccinated against COVID-19, and if they had not, they were asked about their reasons for vaccine hesitancy. Logistic regression models were used to determine factors associated with vaccine hesitancy. Results: In all, 5,384 (39.7%) individuals completed the questionnaire. The main reasons for vaccine hesitancy were worries about adverse effects (57.6%) and the belief that natural immunity is better than vaccination (43.8%). Factors associated with vaccine hesitancy included female sex, younger age, being divorced, a country of origin other than Denmark, lower educational level, being unemployed, previously infected with COVID-19 and being worried to a greater extent about oneself and others getting infected. Mental health indicators were not associated with vaccine hesitancy. Conclusions: COVID-19 vaccine hesitancy is likely to pose a challenge for population immunity. To reduce vaccine hesitancy and increase vaccination uptake, future vaccination programmes should focus on specific socio-demographic subgroups identified in this study.
The role of community trust for compliance with the Swedish COVID-19 immunisation programme
Authors: Mankell Anna , Abdelzadeh Ali 
Published: January 2023

Background and aims: During the COVID-19 pandemic, vaccination as an important and engaging topic once again entered the public debate in many countries, including Sweden. In particular, the varying degree to which different social groups tend to choose to get vaccinated was raised as a point of discussion on the agenda. Thus, the aim of this study was to investigate the role of various forms of trust, especially community trust, in the explanation of vaccine coverage in the Swedish COVID-19 immunisation programme. Methods: In this study, individual survey data from the Swedish Trust Barometer were aggregated and combined with socio-demographic register-based data at Regional Statistical Areas (RegSO) to examine the relationship between trust and vaccine coverage at the local community level. Results: The results showed that both generalised and institutional trust seemed to be essential when it comes to explaining vaccination coverage. In addition, we showed that community trust, that is, trust in neighbours and people living in the neighbourhood, was an even stronger factor when it comes to explaining vaccination coverage at the local level. Conclusions: This article contributes to the literature on trust in relation to health care by identifying a new dimension of trust with significance to immunisation that is worthy of future scholarly attention.
A Comparison of Social Exclusion Towards People with Depression or Chronic Back Pain
Authors: Roberts-West Lucy , Gravatt Amy , Guest Natasha , Hunt Ashley , Siddique Laraib , Serbic Danijela 
Published: January 2023

Objectives Research comparing mental and physical health stigma is scarce. The aim of this study was to compare social exclusion towards hypothetical males and females with depression or chronic back pain. Furthermore, the study investigated whether social exclusion is associated with participant’s empathy and personality traits, while controlling for their sex, age and personal exposure to mental/physical chronic health conditions. Design This study employed a cross-sectional questionnaire design. Methods Participants ( N = 253) completed an online vignette-based questionnaire and were randomly allocated to either a depression or chronic back pain study condition. Measures of social exclusion through respondents’ willingness to interact with hypothetical individuals, empathy and the Big Five personality traits were completed. Results Willingness to interact scores did not significantly differ depending on the diagnosis or sex of the hypothetical person in the vignette. For depression, higher levels of conscientiousness significantly predicted less willingness to interact. Whilst being a female participant and having higher empathy significantly predicted greater willingness to interact. For chronic back pain, higher empathy significantly predicted greater willingness to interact, with no significant predictors found from the Big Five personality traits. Conclusion Findings indicate that females and males with depression or chronic back pain face similar levels of social exclusion, with empathy being a core variable driving social exclusion behaviours. These findings enhance our understanding of potential variables driving social exclusion, in-turn informing campaign development to reduce public stigma towards depression and chronic back pain.
Combination of automated sample preparation and micro-flow LC–MS for high-throughput plasma proteomics
Authors: Ye Xueting , Cui Xiaozhen , Zhang Luobin , Wu Qiong , Sui Xintong , He An , Zhang Xinyou , Xu Ruilian , Tian Ruijun 
Published: January 2023

Abstract
Background
Non-invasive detection of blood-based markers is a critical clinical need. Plasma has become the main sample type for clinical proteomics research because it is easy to obtain and contains measurable protein biomarkers that can reveal disease-related physiological and pathological changes. Many efforts have been made to improve the depth of its identification, while there is an increasing need to improve the throughput and reproducibility of plasma proteomics analysis in order to adapt to the clinical large-scale sample analysis.

Methods
We have developed and optimized a robust plasma analysis workflow that combines an automated sample preparation platform with a micro-flow LC–MS-based detection method. The stability and reproducibility of the workflow were systematically evaluated and the workflow was applied to a proof-of-concept plasma proteome study of 30 colon cancer patients from three age groups.

Results
This workflow can analyze dozens of samples simultaneously with high reproducibility. Without protein depletion and prefractionation, more than 300 protein groups can be identified in a single analysis with micro-flow LC–MS system on a Orbitrap Exploris 240 mass spectrometer, including quantification of 35 FDA approved disease markers. The quantitative precision of the entire workflow was acceptable with median CV of 9%. The preliminary proteomic analysis of colon cancer plasma from different age groups could be well separated with identification of potential colon cancer-related biomarkers.

Conclusions
This workflow is suitable for the analysis of large-scale clinical plasma samples with its simple and time-saving operation, and the results demonstrate the feasibility of discovering significantly changed plasma proteins and distinguishing different patient groups.