bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Elderly Patients Admitted to the Intensive Care Unit for Newly Diagnosed Acute Myeloid Leukemia
Authors: Berton Guillaume , Hospital Marie‐Anne , Garciaz Sylvain , Rouzaud Camille , Maisano Valerio , Hicheri Yosr , D'Incan Corda Evelyne , Rey Jerome , Bisbal Magali , Sannini Antoine , Chine Laurent Chow , Servan Luca , Gonzalez Frederic , Vey Norbert , Mokart Djamel , Saillard Colombe 
Published: January 2025

ABSTRACTAcute myeloid leukemias (AMLs) are the hematological malignancies with the highest need for intensive care unit (ICU) admission due to their association with various life‐threatening situations. Limited data exist regarding the outcomes of elderly individuals with AML admitted to the ICU. However, current therapeutic protocols offer the potential for extended survival in this population. This retrospective, monocentric study focused on the outcomes of individuals aged ≥ 60 years admitted to the ICU for newly diagnosed AML. It included 139 patients admitted to the ICU at the Paoli‐Calmettes Institute between April 2010 and October 2020, during the initial phase of AML management. Patients were categorized into three groups based on the presence of biological criteria indicating “high risk” for complications (thrombocytopenia < 50 000/mm3 and leukocytosis > 50 000/mm3) and organ failure. Multiple logistic regression models were employed to identify predictive factors for in‐hospital and day 90 mortality, while Cox regression was used for 1‐year mortality. The rates of in‐hospital, day 90, and 1‐year mortality were 37%, 42%, and 60%, respectively. Variables associated with in‐hospital mortality included the Charlson Comorbidity Index, the need for invasive mechanical ventilation (MV), and multi‐organ failure. ELN17 risk was significantly associated with 1‐year mortality rates. This study demonstrates the benefits of ICU management for individuals aged ≥ 60 years during the initial phase of AML. It illustrates the effects of age, comorbidities, and the severity of organ failures on short‐term mortality and highlights the impact of classical prognostic markers on long‐term mortality.
Overfishing Social Fish
Authors: Wilson James A. , Giske Jarl , Brown Culum 
Published: January 2025

ABSTRACTSocial learning is common among vertebrates, including fish. Learning from others reduces the risk and costs of adaptation. In some longer‐lived species, social learning can lead to the formation of persistent groups that pass learned adaptations from one generation to the next (culture). Variations in learned adaptations are subject to natural selection, leading to a second, fast‐paced, fine‐scale evolutionary process that complements genetics and enables adaptation to the peculiarities of local areas. Socially learned knowledge is stored mainly in the minds of older fish and subsequently inherited (learned) by younger fish. Consequently, the persistence of locally adapted groups of long‐lived fish requires the inheritance of genetic and learned adaptations. Local populations of social learners are not often recognised nor conserved by fisheries managers. Fishing usually reduces the relative abundance of older fish far more than younger. We hypothesise that fishing may impair and eventually erase the learned local adaptations of long‐lived fish, leading to the loss of local stocks of these species and significant ecosystem‐wide changes. Fishing may shift abundance towards species not dependent on learned adaptations, i.e., invertebrates and short‐lived fish. The hypothesis leads directly to the idea that conserving populations of long‐lived social learners is likely best accomplished by protecting age and social structure or, more generally, the natural processes, such as social learning, that generate complexity in an adaptive ecosystem. Local area‐based management is aligned with the local processes of social learners and can capture and learn about the effect of human activity at that scale.
Long‐Term Variability in the Southwest Atlantic Marine Fishery Ecosystems in Relation to Climate Change
Authors: Liu Hewei , Zhang Ping , Cao Jie , Yu Wei , Chen Xinjun 
Published: January 2025

ABSTRACTExploring the impacts of climate variability on the marine fishery ecosystems in the Southwest Atlantic Ocean is conducive to establishing an ecosystem‐based approach for the protection and rational utilization of fishery resources. In this study, long‐term fisheries data, 23 environmental data from the entire Southwest Atlantic, and 25 global climate data have been used to explore the regime shift of the fishery ecosystem and the response of fishery resources to climate change from 1950 to 2018. The results indicated that changes in the Southwest Atlantic fishery ecosystem exhibited a significant nonstationary trend, and there were three noteworthy regime shifts in 1976/1977, the late 1980s, and the late 20th century. The temperature, sea surface height, water runoff, and cloudiness were the environmental variables with the greatest impact on fishery resources within the Southwest Atlantic Fishery Ecosystem, while zonal wind speed and air temperature yielded a more significant impact on low latitude areas. In terms of climate indices, fishery resources have the most obvious response to the Global Mean Land‐Ocean Temperature Index and Antarctic Sea Ice Extent, and the Atlantic Multidecadal Oscillation had an intense impact on low latitude areas concurrently. The study highlights the climate‐related nonstationary changes in the Southwest Atlantic fishery ecosystem.
Acetone detection at reduced temperatures: Engineering Cl‐doped ZnO nanodisks for enhanced gas‐sensing performance
Authors: Zhu Bingxing , Safari Fatemeh , Ebadi Mehdi , Sookhakian Mehran , Yousefi Ramin 
Published: January 2025

AbstractThis study presents the development of a groundbreaking acetone gas sensor leveraging Cl‐doped ZnO nanodisks, designed to operate efficiently at low temperatures. Through comprehensive experimental and theoretical analyses, they have elucidated the exceptional sensing capabilities of Cl‐doped ZnO nanodisks. Both undoped and Cl‐doped ZnO with varying chlorine concentrations were synthesized on Si/SiO2 substrates using a straightforward thermal evaporation method in a tube furnace. Notably, the morphology of pure ZnO formed microdisks, whereas the Cl‐doped ZnO transitioned to nanodisks, and with increased Cl doping, it further evolved into nanoplates. X‐ray diffraction and x‐ray photoelectron spectroscopy (XPS) confirmed the successful substitution of oxygen ions with chlorine ions. Enhanced photoluminescence and XPS analyses revealed that Cl‐doped ZnO contained a significantly higher density of oxygen vacancies compared to undoped ZnO. The Cl‐doped ZnO sensor exhibited an outstanding sensitivity of approximately 40 and an impressive selectivity of 55% toward 100 ppm acetone at 80°C. Cl doping markedly improved the sensor's response and recovery times, enabling the detection of acetone at concentrations as low as 225 ppb at 80°C—a remarkable achievement unattainable with pure ZnO. All characterization results strongly indicate that oxygen vacancies play a pivotal role in enhancing the gas‐sensing performance of Cl‐doped ZnO nanodisks. Cutting‐edge density functional theory calculations uncovered significant interactions between acetone and Cl‐doped ZnO through charge density variations and band structure analysis. These interactions resulted in notable changes in the density of states, including a distinct peak near −3 eV, indicating enhanced sensitivity.
The phase diagram and strengthening behavior of compositionally complex carbides under high pressure
Authors: Ran Ling , Guan Shixue , Liang Wenjia , Pu Jieru , He Peihong , Long Haidong , Yang Peng , Peng Fang 
Published: January 2025

AbstractThe application of compositionally complex carbides under extreme conditions has garnered significant attention. The phase diagram compositionally complex transition metal carbide (Ta0.2Nb0.2Hf0.2Zr0.2V0.2)C for synthesis under high‐pressure and high‐temperature has been systematically investigated for the first time, and a pressure‐induced decrease in the compositionally complex carbides phase formation temperature was observed. The asymptotic Vickers hardness and bulk modulus of (Ta0.2Nb0.2Hf0.2Zr0.2V0.2)C reached 24.0 GPa and 311.3 GPa. The bulk modulus demonstrates an approximate 30% improvement compared to the average values of individual carbides, indicating that it possesses relatively competitive mechanical properties within the compositionally complex carbides group. The Claperon equation has been utilized to predict the lattice contraction of compositionally complex carbides during phase formation, and the physical mechanism of the high‐pressure strengthening has been proposed accordingly. In summary, the research of pressure–temperature phase diagram and the high‐pressure strengthening mechanism lay a valuable theoretical basis for the structural design and performance optimization of novel compositionally complex carbides.
Structural and electric properties of Na super ionic conductor solid electrolyte MIIx/2Li1−xTi2(PO4)3 (MII = Mg, Zn, and Cd)
Authors: Bouftila Nour El Hoda , Chouiekh Abdelhak , Bih Lahcen , Faik Abdessamad , Rjeb Abdelilah , Ababou Yahya , Naji Mohamed 
Published: January 2025

AbstractAll‐solid‐state lithium‐ion batteries, employing solid electrolytes, offer a promising solution to address safety concerns inherent in conventional lithium‐ion batteries. Among the various types of Li‐ion solid electrolytes, LiTi2(PO4)3 (LTP) with the Na Super Ionic CONductor (NASICON) structure stands out as a particularly attractive material, despite its relatively low ionic conductivity at room temperature. One approach to enhance the performance of LTP solid electrolytes involves modifying the network size or redistributing Li cations and vacancies within the adjacent sites of the NASICON structure. Therefore, this study seeks to replace lithium ions with divalent cations, thereby increasing the concentration of vacancies, and facilitates the migration of Li+ ions between adjacent partially populated M1 sites. Introducing divalent elements not only augments vacancies in the lithium sites but also induces variations in local disorder within NASICON structures. Consequently, NASICON compounds, MIIx/2Li1−xTi2(PO4)3 (MII = Mg, Zn, and Cd), were synthesized via the sol–gel method, and their structural, microstructural, and electrical properties were thoroughly analyzed using a variety of techniques. The presence of divalent cations in the M1 site results in a reduction of symmetry and an enhancement of local disorder. A correlation between ionic conductivity and structure was established, which was linked to the disorder of lithium atoms within the structure. Electric modulus formalism was employed to explore electric relaxation, revealing that the diffusion and relaxation processes are thermally activated.
Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Patients With Atrioventricular Block: A Systematic Review and Meta‐Analysis
Authors: Ahsan Irfan , Hennawi Hussam Al , Bedi Angad , Khan Muhammad Khuzzaim , Duseja Nikhil , Ho Reginald T. 
Published: January 2025

ABSTRACTBackgroundLeft bundle branch area pacing (LBBAP) is a new technique for patients with atrioventricular block (AVB) and preserved left ventricular ejection fraction (LVEF), potentially offering better cardiac function than right ventricular pacing (RVP).MethodsWe searched databases and registries for studies that compared LBBAP with RVP in patients with AVB and preserved LVEF. We extracted data on various outcomes and pooled the effect estimates using random‐effects models.ResultsOur meta‐analysis included 14 studies (10 observational and 4 RCTs) involving 3062 patients with AVB. The analysis revealed that the QRS duration was significantly shorter in the LBBAP group compared to the RVP group [MD = −35.56 ms; 95% CI: (−39.27, −31.85), p < 0.00001]. Patients in the LBBAP group also exhibited a significant increase in left ventricular ejection fraction (LVEF) [MD = 5.48%; 95% CI: (4.07%, 6.89%), p < 0.00001], and a significant reduction in left ventricular end‐diastolic diameter (LVEDD) compared to RVP [MD = −3.98 mm; 95% CI: (−5.88, −2.09 mm), p < 0.0001]. In terms of clinical outcomes, LBBAP was associated with a significantly lower risk of heart failure hospitalizations (HFHs) compared to RVP [OR = 0.26; 95% CI: (0.16, 0.44), p < 0.0001]. However, no significant differences were observed between the two groups in the implant success rate, pacing impedance, or pacing threshold. The RVP group demonstrated a significantly higher R‐wave amplitude increase than the LBBAP group [MD = 0.85 mV; 95% CI: (0.23, 1.46), p = .007]. Lastly, there was no significant difference in the incidence of complications between the two groups [OR = 2.12; 95% CI: (0.29, 15.52), p = 0.46].ConclusionLBBAP outperforms RVP in several cardiac function indicators, suggesting it may be a superior pacing method for AVB patients with preserved LVEF. However, the small sample size in studies and the result in heterogeneity call for more research to validate these findings and assess LBBAP's long‐term effects.
Retrieval of an Aveir Leadless Pacemaker With a Standard Retrieval Catheter by Releasing the Wedged Docking Button Using a Loop Wire Technique
Authors: Yano Kensuke , Shinohara Masaya , Sasaki Hideto , Suzuki Takuto , Kikushima Hosei , Wada Ryo , Yao Shintaro , Koike Hideki , Fujino Tadashi , Ikeda Takanori 
Published: January 2025

ABSTRACTIntroductionThe docking button of the Aveir leadless pacemaker (LP) is occasionally difficult to access due to its inappropriate position in the right ventricle (RV).Methods and ResultsWe report a case where the Aveir LP was successfully retrieved by releasing the wedged docking button in the inferior wall of the RV using a loop wire technique.ConclusionThe loop wire technique may be useful to change the position of the Aveir LP. This may be helpful to retrieve the Aveir LP even in a case where the docking button is wedged in the inferior wall of the RV.
Dynamin‐Related Protein 1 Orchestrates Inflammatory Responses in Periodontal Macrophages via Interaction With Hexokinase 1
Authors: Jiang Yiming , Wang Zihan , Zhang Kaige , Hu Yue , Shang Dehao , Jiang Lulu , Huang Minghao , Wang Biyao , He Xiaomin , Wu Zhou , Yan Xu , Zhang Xinwen 
Published: January 2025

ABSTRACTAimTo explore the potential roles of mitochondrial dysfunction in the initiation of inflammation in periodontal macrophages and to determine the mechanism underlying the involvement of dynamin‐related protein 1 (Drp1) in macrophage inflammatory responses through its interaction with hexokinase 1 (HK1).Materials and MethodsGingival tissues were collected from patients diagnosed with periodontitis or from healthy volunteers. Drp1 tetramer formation and phosphorylation were analysed using western blot. THP‐1 macrophages and RAW264.7 cells were stimulated with Porphyromonas gingivalis (Pg) or Pg lipopolysaccharide (Pg LPS), respectively. Alterations in proteins associated with mitochondrial dynamics were scrutinized via western blot. Immunofluorescence was used to evaluate mitochondrial damage and mitochondrial permeability transition pore (mPTP) opening. Western blot was used to examine the inflammatory markers NLRP3, caspase‐1, IL‐1β and GSDMD. Protein interactions involving Drp1 were verified through immunoprecipitation.ResultsIn periodontitis patient samples, Pg LPS‐treated RAW264.7 cells, and Pg‐stimulated THP‐1 macrophages, over‐activated Drp1 was able to drive NLRP3 inflammasome activation and the subsequent release of inflammatory factors. A direct interaction between Drp1 and HK1 was observed, facilitating excessive mPTP opening and subsequent mitochondrial dysfunction.ConclusionIn the inflammatory milieu of periodontal tissues, Drp1 hyperactivation in the macrophages is implicated in inflammation induction. Modulation of the inflammatory response in periodontal macrophages by Drp1 appears to facilitate mPTP opening.
Clinical significance of small dense low‐density lipoprotein cholesterol measurement in type 2 diabetes
Authors: Hirano Tsutomu 
Published: January 2025

ABSTRACTLow‐density lipoprotein cholesterol (LDL‐C) is known to be a causal substance of atherosclerosis, but its usefulness as a predictive biomarker for atherosclerotic cardiovascular disease (ASCVD) is limited. In patients with type 2 diabetes (T2D), LDL‐C concentrations do not markedly increase, while triglycerides (TG) concentrations are usually elevated. Although TG is associated with ASCVD risk, they do not play a direct role in the formation of atheromatous plaques. TG changes the risk of ASCVD in a way that is dependent on LDL‐C, and TG is the primary factor in reducing LDL particle size. Small dense (sd)LDL, a potent atherogenic LDL subfraction, best explains the “Atherogenic Duo” of TG and LDL‐C. Although hypertriglyceridemia is associated with small‐sized LDL, patients with severe hypertriglyceridemia and low LDL‐C rarely develop ASCVD. This suggests that quantifying sdLDL is more clinically relevant than measuring LDL size. We developed a full‐automated direct sdLDL‐C assay, and it was proven that sdLDL‐C is a better predictor of ASCVD than LDL‐C. The sdLDL‐C level is specifically elevated in patients with metabolic syndrome and T2D who have insulin resistance. Due to its clear link to metabolic dysfunction, sdLDL‐C could be named “metabolic LDL‐C.” Insulin resistance/hyperinsulinemia promotes TG production in the liver, causing steatosis and overproduction of VLDL1, a precursor of sdLDL. sdLDL‐C is closely associated with steatotic liver disease and chronic kidney disease, which are common complications in T2D. This review focuses on T2D and discusses the clinical significance of sdLDL‐C including its composition, pathophysiology, measurements, association with ASCVD, and treatments.
Comment on: Clinical Performance of Existing Diagnostic Criteria for Pneumonia in Older Emergency Patients: A Prospective Cohort Study
Authors: Turgut Zeynep Iclal , Ozkan Emre , Cicek Orhan , Dogan Mustafa Hakan , Akkar Ilyas , Kars Merve Yilmaz , Kizilarslanoglu Muhammet Cemal 
Published: January 2025

See the related reply by Hunold and Caterino.
Dissemination of the Care Ecosystem Collaborative Care Model for Dementia
Authors: Sideman Alissa B. , Dulaney Sarah , Merrilees Jennifer , Barclay Michelle , Hernandez de Jesus Alma , Possin Katherine L. 
Published: January 2025

ABSTRACTBackgroundDementia represents a growing healthcare challenge in the United States. The Care Ecosystem, an effective collaborative care model, bridges medical and social care needs for individuals with dementia. The purpose of this study was to describe how the Care Ecosystem has been disseminated and the lessons learned from this experience.MethodsInterested site leaders from both health systems and community‐based organizations reviewed online implementation support materials and consulted with Care Ecosystem directors. Those that decided to move forward with implementation were invited to join monthly ‘Implementation Meetings.’ Observations of these meetings and review of minutes were combined with site surveys and interviews, which were analyzed using qualitative and descriptive methods.ResultsImplementation efforts resulted in the adoption of the Care Ecosystem at 28 health systems and eight community‐based organizations, including 22 participants in Medicare's Guiding an Improved Dementia Experience (GUIDE) payment model. The Implementation Meetings facilitated collaborative learning and adaptation and supported fidelity to core model elements. The Care Ecosystem's flexible approach and open‐source materials enabled tailored implementations that align with local contexts and population needs.ConclusionsThe Care Ecosystem exemplifies a scalable approach to dementia care, guided by implementation science principles to bridge the gap between research and real‐world application. Its success in improving patient outcomes and reducing healthcare costs underscores its potential to enhance dementia care delivery on a broader scale. Future efforts should focus on refining implementation strategies, enhancing fidelity monitoring, and expanding partnerships to sustain and scale effective dementia care practices across diverse healthcare settings.
NLR‐mediated antiviral immunity in plants
Authors: Zhu Min , Feng Mingfeng , Tao Xiaorong 
Published: January 2025

ABSTRACTPlant viruses cause substantial agricultural devastation and economic losses worldwide. Plant nucleotide‐binding domain leucine‐rich repeat receptors (NLRs) play a pivotal role in detecting viral infection and activating robust immune responses. Recent advances, including the elucidation of the interaction mechanisms between NLRs and pathogen effectors, the discovery of helper NLRs, and the resolution of the ZAR1 resistosome structure, have significantly deepened our understanding of NLR‐mediated immune responses, marking a new era in NLR research. In this scenario, significant progress has been made in the study of NLR‐mediated antiviral immunity. This review comprehensively summarizes the progress made in plant antiviral NLR research over the past decades, with a focus on NLR recognition of viral pathogen effectors, NLR activation and regulation, downstream immune signaling, and the engineering of NLRs.
An In Vitro Nutritional Evaluation of Mixed Silages of Drought‐Impaired Grass and Sugar Beet Pulp With or Without Silage Inoculants
Authors: Gruber Theresa , Lang Claudia , Fliegerová Katerina , Terler Georg , Zebeli Qendrim , Hartinger Thomas 
Published: January 2025

ABSTRACTIncreasing droughts adversely affect grasslands, diminishing the availability and quality of forages for ruminants. We have recently shown that mixed ensiling of drought‐impaired grass (DIG) with sugar beet pulp (SBP) improved the conservation and feed value of silage. The application of silage additives may further improve the ruminal degradability, which may thereby shape the fermentation and microbiome in the rumen when those silages are tested as part of dairy diets. Therefore, we performed a long‐term in vitro nutritional evaluation of diets containing 50% (DM basis) of mixed silages from DIG and SBP, ensiled either with no additive (T_CON) or with anaerobic fungi culture supernatant (25% in DM; T_AF), mixed ruminal fluid (10% in DM; T_RF) or lactic acid bacteria (1% in FM; T_LAB). The data showed a high degradability of all diets (e.g., > 70% for organic matter), though without differences in nutrient degradabilities among treatments (p > 0.05). Fermentation characteristics, such as ruminal pH, short‐chain fatty acid profile, and gas production were only marginally affected by the treatments. Isobutyric acid proportion was higher in T_CON than in T_AF (p = 0.01), whereas isovaleric acid proportion was lower in T_LAB than in T_RF (p = 0.01). The analysis of the bacterial community revealed similar diversity and structure across all treatments in both the liquid and solid fraction. Noteworthy, Lactobacillus was among the predominant genera in the liquid fraction, which may have derived from the mixed silages. In conclusion, mixed silages from DIG and SBP as part of a 50% concentrate diet showed high ruminal degradability, but no beneficial impact by the tested silage additives was observed. Hence, under these conditions, their application appears not justified. Our results warrant further in vivo verification, whereby it would be of interest to determine the impact of the applied silage additives in forage‐based diets (e.g., > 50% silage in diet DM) in future research.