bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating human-computer interaction education based on active learning methods using the CRITIC and TOPSIS approach
Authors: Li Qiaoling , Yin Xiufeng , Yin Weili , Dong Xia , Li Qingqing 
Published: January 2023

Abstract
With the ever-growing development of information technology, the education sector has adopted advanced technologies to improve this field. Different procedures based on human-computer interaction (HCI) can be applied to the efficient interaction between humans and computers to enhance the productivity of computers in various fields, especially in education. Active learning is one of the major technological fields that improves the usability of active learning. With the implementation of HCI approaches such as project-based learning (PBL), active learning classrooms (ALCs), and multi-user virtual environments (MUVE), students’ learning capabilities and teachers’ teaching skills are improved and education becomes more effective. After studying different applications of HCI in active learning, the study proposed to extract common features and select the most efficient ones from them. For the evaluation process, we presented two techniques named Criteria Importance Through Inter Correlation (CRITIC) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) in order to select the most effective HCI approach among various options. We choose nine criteria along with ten alternatives and rank them based on their performance scores. For assigning weights to criteria, we utilized the CRITIC strategy, while the TOPSIS technique is applied for ranking the alternatives. In the proposed study, it is identified that the alternative with the highest performance score is kept in first place, while the alternative with the worst performance score is kept at the bottom. The study concluded that the efficient and effective approach was selected among various options, and it can be employed as a suggestion for decision-related issues and future directions.
The Role of Gestational Diabetes Mellitus and Pelvic Floor 3D-ultrasound assessment during pregnancy predicting Urinary Incontinence: Preliminary results from a prospective cohort study
Authors: Filho Carlos Izaias Sartorao , Nunes Sthefanie K. , Magyori Adriely B. M. , Calderon Iracema M.P. , Barbosa Angelica M. P. , Rudge Marilza V. C. 
Published: January 2023

Abstract
Postpartum urinary incontinence may have a severe impact on women's health. Despite pregnancy and parturition being the most recognized risk factors, methods to identify new pregnant predictor risk factors are needed. Our study investigated the Gestational Diabetes Mellitus, clinical and pelvic floor 3D-ultrasound markers in pregnant women as predictors for 6-18 months of urinary incontinence. This prospective cohort study included nulliparous pregnant women submitted to Gestational Diabetes Mellitus screening in the second trimester. Pelvic floor 3D Ultrasound was performed at the second and third trimesters of gestation to evaluate the pelvic floor muscles and functions. Clinical data, the ICIQ-SF, and ISI questionnaires for urinary incontinence were applied in the third trimester and 6-18 months postpartum. Univariate analysis (P<.20) to extract risk factors variables and multivariate logistic regression analysis (P<.05) to obtain the adjusted relative ratio for urinary incontinence were performed. A total of 93 participants concluded the follow-up. Using the variables obtained by univariate analysis and after adjustments for potential confounders, multivariate analysis revealed that Gestational Diabetes Mellitus exposure was a solid and independent risk factor for 6-18 months of urinary incontinence (Adjusted RR 8.088; 95%CI 1.17-55.87; P:.034). In addition, a higher Hiatal area observed in distension maneuver from the second to third trimester was negatively correlated (Adjusted RR 0.966; 95%CI 0.93-0.99; P:.023). In conclusion, Gestational Diabetes Mellitus was positively correlated with 6-18 months of urinary incontinence, and higher Hiatal area distension was negatively correlated.
Geschichte der Erforschung der Sommerwurzgewächse (Gattungen Orobanche und Phelipanche)
Authors: Uhlich Holger 
Published: January 2023

Teil 2 der Reihe beleuchtet die systematische Erforschung der Gattungen Orobanche und Phelipanche in der Periode von Linnés "Species Plantarum" 1753 bis zur ersten grundlegenden Monographie zur Gattung Orobanche von G. Beck 1890. ein abschließender Abschnitt bringt Ergänzungen zum ersten Teil (behandelte den Zeitraum von den Anfängen bis 1753; Kochia 8: 27–61). Fünf Neukombinationen werden vorgenommen: (1) Myzorrhiza californica subsp. grayana (Beck) Uhlich, (2) Phelipanche mutelii var. nana (Reut.) Uhlich & Rätzel, (3) Phelipanche mutelii var. nana f. manostachys (Beck) Uhlich & Rätzel, (4) Phelipanche caesia var. borealis (Turcz.) Uhlich und (5) Diphelypaea coccinea var. boissieri (Reut.) Uhlich.
Research Status, Synthesis and Clinical Application of Antiepileptic Drugs
Authors: Wang Si-Jie , Zhao Min-Yan , Zhao Peng-Cheng , Zhang Wen , Rao Guo-Wu 
Published: January 2023

Abstract:
According to the 2017 ILAE's official definition, epilepsy is a slow brain dis-ease state characterized by recurrent episodes. Due to information released by ILAE in 2017, it can be divided into four types, including focal epilepsy, generalized epilepsy, combined generalized, and focal epilepsy, and unknown epilepsy. Since 1989, 24 new an-tiepileptic drugs have been approved to treat different types of epilepsy. Besides, there are a variety of antiepileptic medications under clinical monitoring. These novel antiepileptic drugs have plenty of advantages. Over the past 33 years, there have been many antiepilep-tic drugs on the mearket, but no one has been found that can completely cure epilepsy. In this paper, the mentioned drugs were classified according to their targets, and the essential information, and clinical studies of each drug were described. The structure-activity rela-tionship of different chemical structures was summarized. This paper provides help for the follow-up research on epilepsy drugs.
The Current Status of Antisense Gene Therapies for Bacteria-caused Diseases
Challenges and Opportunities
Authors: Ding Feng , Li Jiawei , Liang Xuejun , Wang Fangxin , Wang Juping 
Published: January 2023

Abstract:
Bacteria-caused diseases continue to pose a serious threat to human health. The current situation of
overused antibiotics against those diseases further spurs and exacerbates the ever-increasing drug resistance
problems, which really leaves us very few options to combat those nasty bugs. Gene therapies based on the antisense
oligonucleotide, though developed more than 40 years ago, did not reform the current treatments as originally
expected. Along with the advances of new delivery technologies, this old field thrives again. In addition,
newly evolving gene-editing tools based on the CRISPR-Cas system shed new light on this old field, bringing a
breeze of hope to gene therapies for bacteria-caused diseases. As a fast-growing field, we strive to summarize
in this review the recent progress in using gene therapies in those areas, analyze the potential challenges or
problems from using antisense or gene-editing tools for targeting bacterial diseases and seek to explore any potential
solutions to the current dilemmas. As a short review, we will focus our discussion mainly on antisense
oligonucleotide-based gene therapies while briefly touching on the CRISPR-Cas based ones as the latter is just
beginning to get more attention for application in the prokaryotic kingdom.
An Algorithm-optimized Scheme for In situ Synthesis of DNA Microarrays
Authors: Cheng Chu , Gu Xingyue , Fei Zhongjie , Xiao Pengfeng 
Published: January 2023

Background:
The cost of synthetic DNA has limited applications in frontier science and technology fields such as synthetic biology, DNA storage, and DNA chips.

Objective:
The objective of this study is to find an algorithm-optimized scheme for the in-situ synthesis of DNA microarrays, which can reduce the cost of DNA synthesis.

Methods:
Here, based on the characteristics of in-situ chemical synthesis of DNA microarrays, an optimization algorithm was proposed. Through data grading, the sequences with the same base at as many different features as possible were synthesized in parallel to reduce synthetic cycles.

Results and Discussion:
The simulation results of 10 and 100 randomly selected sequences showed that when level=2, the reduction ratio in the number of synthetic cycles was the largest, 40% and 32.5%, respectively. Subsequently, the algorithm-optimized scheme was applied to the electrochemical synthesis of 12,000 sequences required for DNA storage. The results showed that compared to the 508 cycles required by the conventional synthesis scheme, the algorithm-optimized scheme only required 342 cycles, which reduced by 32.7%. In addition, the reduced 166 cycles reduced the total synthesis time by approximately 11 hours.

Conclusions:
The algorithm-optimized synthesis scheme can not only reduce the synthesis time of DNA microarrays and improve synthesis efficiency, but more importantly, it can also reduce the cost of DNA synthesis by nearly 1/3. In addition, it is compatible with various in-situ synthesis methods of DNA microarrays, including soft-lithography, photolithography, a photoresist layer, electrochemistry and photoelectrochemistry. Therefore, it has very important application value.
Study on the Mechanism of Astragalus Polysaccharides on Cervical Cancer
Based on Network Pharmacology
Authors: Liu Wen-Zhi , Yu Min-Min , Kang Min 
Published: January 2023

Background:
Astragalus polysaccharides (APS) is a natural phytochemical which has been extensively utilized for anti-tumor therapy over the past few years. However, its impact on cervical cancer (CC) has rarely been studied.

Objective:
To clarify the exact mechanism of anti-cancer effects of Astragalus polysaccharides (APS) on Cervical Cancer (CC), we screened differentially expressed genes (DEGs) from The Cancer Genome Atlas (TCGA) to construct the cancer network.

Methods:
Then we performed functional enrichment analysis with gene ontology (GO) and KEGG pathway analyses, constructed protein-protein interaction (PPI) network, and performed molecular docking (MD) analysis to identify the key gene for docking with APS. Further, we observed the effects of APS on cell proliferation, cell cycle, and apoptosis experiments in HeLa cells. qRT-PCR and western blot were used to detect the expression of target genes.

Results:
A total of 793 DEGs were screened using criteria, which included 541 genes that were up-regulated and 251 genes that were down-regulated. Using topological attributes for identifying critical targets, molecular docking (MD), and survival analyses, this study predicted the APS targets: POLO-like kinase 1(PLK1), Cyclin-cell division 20(CDC20), and Cyclin-dependent kinase 1 (CDK1), which regulated HeLa cells. The results of cell proliferation, cell cycle, and apoptosis experiments concluded that APS inhibited the development of HeLa cells in a concentration-dependent manner. Also, qRT-PCR and western blot experiments demonstrated that APS could significantly down-regulate the expression of PLK1, CDC20, and CDK1 in the CC cells.

Conclusion:
The result revealed that APS might have a therapeutic potential in treating CC and might permit intervention with treatments targeting PLK1, CDC20, and CDK1.
Enhanced Brain Targeting Delivery of Salvianic Acid Using Borneol as a Promoter of Blood/Brain Transport and Regulator of P-gp
Authors: Hui Ailing , Zhang Zheng , Wang Jinghe , Yang Li , Deng Shaohuan , Zhang Wencheng , Zhou An , Wu Zeyu 
Published: January 2023

Background:Borneol can enhance the blood-brain barrier (BBB) permeability of some drugs and suppress the efflux transport of P-glycoprotein (P-gp), which will contribute to the brain delivery of salvianic acid A (SAA).Objective:The study aimed to develop an approach to improve the brain targeting delivery of SAA with the aid of borneol.Materials and Methods:“Borneol” was involved in SAA via esterified prodrug SAA borneol ester (SBE) and combined administration (SAA-borneol, SAA-B). Subsequently, the blood-brain transport of SAA through brain/blood distribution and P-gp regulation via expression and function assay were investigated in rats.Results:The SBE and SAA-B-treated group received a three-fold brain concentration and longer t1/2 and retention period of active SAA than that of SAA alone (20.18/13.82 min vs. 6.48 min; 18.30/17.42 min vs. 11.46 min). In addition, blood to brain transport of active SAA in SBE was altered in comparison to that of SAA-B, ultimately resulting in a better drug targeting index (9.93 vs. 3.63). Further studies revealed that SBE-induced downregulation of P-gp expression occurred at the later stage of administration (60 min, P < 0.01), but SBE always showed a more powerful drug transport activity across BBB represented by Kp value of rhodamine 123 than SAA-B (30, 60 min, P < 0.05).Conclusion:The comparative results indicate that SBE exhibits prominent efficiency on SAA's targeting delivery through improved blood/brain metabolic properties and sustained inhibitory effect of “borneol” on P-gp efflux. Therefore, prodrug modification can be applied as a more effective approach for brain delivery of SAA.
The Non-hodgkin Lymphoma Treatment and Side Effects: A Systematic
Review and Meta-analysis
Authors: Câmara Alice Barros , Brandão Igor Augusto 
Published: January 2023

Objective:
This paper aims to review studies regarding side effects found during Non-
Hodgkin Lymphoma treatment, to suggest the drug class most associated with these effects, as
well as the most prevalent side effect grade.

Methods:
This review is registered in PROSPERO (IDCRD42022295774) and followed the PICOS
strategy and PRISMA guidelines. The search was carried out in the databases PubMed/
MEDLINE, Scientific Electronic Library Online, and DOAJ. Medical Subject Headings Terms
were used and quantitative studies with conclusive results regarding side effects during the
non-Hodgkin lymphoma treatment were selected. Patent information was obtained from google
patents.

Results:
Monoclonal antibodies were the main drug class associated with side effects during NHL
therapy. The combination of Rituximab (Rituxan®; patent EP1616572B) and iInotuzumab (Besponsa
®; patent EP1504035B3) was associated with a higher incidence of thrombocytopenia (p < 0.05),
while the combination of Rituximab and Venetoclax (Venclexta®; patent CN107089981A) was associated
with a higher incidence of neutropenia (p < 0.05) when compared to Bendamustine combinations
(Treanda™; patent US20130253025A1). Meta-analysis revealed a high prevalence of grade 3-4
neutropenia and thrombocytopenia in men. Finally, Americans and Canadians experienced a higher
prevalence of these side effects, when compared to others nationalities (p < 0.05).

Conclusion:
Patents regarding the use of monoclonal antibodies in NHL treatment were published
in the last year. Monoclonal antibodies associated with neutropenia (grade 3-4) and thrombocytopenia,
especially in North American men treated for NHL, and with an average age of 62 years
demonstrated importance in this study.
Non-Insulin-Based Insulin Resistance Indices and Localized Periodontitis in
Physically Active Young Male Adults: CHIEF Oral Health Study
Authors: Lin Gen-Min , Tsai Kun-Zhe , Lin Yen-Po , Lai Shiue-Wei , Liu Chia-Hsin , Chang Yun-Chen 
Published: January 2023

Aims:
This study aims to examine the association between non-insulin-based insulin
resistance indices and periodontitis severity in young males.

Background:
Periodontitis has been reported with an association with insulin resistance in middle-
and old-aged adults.

Objective:
The association between insulin resistance and localized periodontitis in young adults
is unclear.

Methods:
A total of non-diabetic 1,111 military males in Taiwan were included in this study.
Localized periodontitis was classified as healthy (N =665), stage I (N =130), stage II (N =161),
and stage III (N =155) based on the world workshop in 2017. Insulin resistance was assessed by
serum triglycerides concentrations, the triglycerides glucose (TyG) index, the product of serum
triglycerides and fasting glucose, and the ratio of serum triglycerides to high-density lipoprotein
cholesterol (TG/HDL-C). Multiple logistic regression analysis with adjustment for age, tobacco
smoking, alcohol intake, abdominal obesity, and hypertension was used to determine the associations.

Results:
Serum TG concentrations, TyG index, and TG/HDL-C ratio were dose-dependently associated
with a greater risk of localized periodontitis severity (from stage I to stage III) [odds
ratios and 95% confidence intervals: 1.001 (0.999-1.004), 1.003 (1.001-1.004) and 1.003 (1.002-
1.005) for TG; 1.45 (1.03-2.03), 1.65 (1.22-2.22) and 1.66 (1.22-2.26) for TyG index; 1.06 (0.99-
1.14), 1.09 (1.03-1.15) and 1.10 (1.04-1.16) for TG/HDL-C ratio]. However, the association was
only found in obese individuals and those free of impaired fasting glucose.

Conclusion:
The present study confirmed that periodontitis may lead to insulin resistance in
young male adults, particularly for those with obesity and without hyperglycemia. The TyG index
is suggestive as the strongest indicator for the association between insulin resistance and periodontitis
in young adults.
Hepatic and Systemic Inflammation for Left Ventricular Mass in Physically
Fit Adults: CHIEF Heart Study
Authors: Lin Gen-Min , Chou Yi-Ting , Chen Kai-Wen , Liu Pang-Yen , Tsai Kun-Zhe , Lin Yen-Po 
Published: January 2023

Background:
Both low-grade systemic and hepatic inflammation could result in increased
left ventricular mass (LVM) in the general population. However, the associations, which
might be modified by exercise, have not been clarified in physically active young adults.

Methods:
The study included 2,004 military males aged 18–43 years in eastern Taiwan. Systemic
and hepatic inflammation was defined by the upper tertiles of blood white blood cell (WBC) counts
(7.51-11.00 x 103/μL) and serum alanine aminotransferase (ALT: 30-120 U/L), respectively. LVM
indexed for the body height ≥49 g/m2.7 was defined as left ventricular hypertrophy (LVH) based
on echocardiography. Multiple logistic regression analysis adjusting for age, smoking, alcohol intake,
physical fitness, and metabolic syndrome was utilized to determine the associations.

Results:
As compared to the lower WBC/lower ALT group, there tended to have an increased risk
of LVH with the higher WBC/lower ALT group, the lower WBC/higher ALT group, and the higher
WBC/higher ALT group [odds ratios: 0.89 (95% confidence intervals (CI): 0.41-1.94), 1.90 (95%
CI: 0.86-4.22) and 2.48 (95% CI: 1.04-5.92); p-value for trend = 0.01].

Conclusion:
Our study suggested that in physically active males, those with hepatic inflammation
rather than low-grade systemic inflammation had a higher risk of LVH. Hepatic injury might be
relevant to LVH as an early sign of end-organ damage regardless of physical fitness in young
adults.
Prototyping of a Digital Life Course Care Platform for Preconception and Pregnancy Care: Pilot Feasibility and Acceptability Study
Authors: van der Windt Melissa , van Zundert Sofie Karolina Maria , Schoenmakers Sam , van Rossem Lenie , Steegers-Theunissen Régine Patricia Maria 
Published: January 2023

Background
A healthy lifestyle plays a key role in the prevention of lifestyle-related diseases, including subfertility and pregnancy complications. Although the benefits of a healthy lifestyle are well-known, long-term adherence is limited. Moreover, memory for lifestyle-related information as well as medical information provided by the medical professional is often poor and insufficient. In order to innovate and improve health care for both the patients and health care professionals, we developed a prototype of a digital life course care platform (Smarter Health app), providing personalized lifestyle care trajectories integrated in medical care journeys.

Objective
This pilot study aimed to evaluate the feasibility, defined as the actual app use, and the acceptability, which included patient satisfaction and appreciation, of the Smarter Health app.

Methods
Between March 17, 2021, and September 30, 2021, pregnant women familiar with the Dutch language seeking tertiary preconception and pregnancy care were offered the app as part of standard medical care at the outpatient clinic Healthy Pregnancy of the Department of Obstetrics and Gynecology of the Erasmus University Medical Center. Three months after activation of the app, patients received a digital questionnaire consisting of aspects of feasibility and acceptability.

Results
During this pilot study, 440 patients visited the outpatient clinic Healthy Pregnancy. Of the 440 patients, 293 (66.6%) activated the app. Of the 293 patients who activated the app, 125 (42.7%) filled out the questionnaire. Of these 125 patients, 48 (38.4%) used the app. Most app users used it occasionally and logged in 8 times during their medical care trajectory. Overall, app users were satisfied with the app (median 5-point Likert scale=2.4, IQR 2.0-3.3).

Conclusions
Our findings showed that the Smarter Health app, which integrates lifestyle care in medical care, is a feasible health care innovation, and that patients were satisfied with the app. Follow-up and evaluation of pregnancy outcomes should be performed to further substantiate wider clinical implementation.
Bayesian hierarchical model-based network meta-analysis to overcome survival extrapolation challenges caused by data immaturity
Authors: Heeg Bart , Verhoek Andre , Tremblay Gabriel , Harari Ofir , Soltanifar Mohsen , Chu Haitao , Roychoudhury Satrajit , Cappelleri Joseph C 
Published: January 2023

Aim:
This research evaluated standard Weibull mixture cure (WMC) network meta-analysis (NMA) with Bayesian hierarchical (BH) WMC NMA to inform long-term survival of therapies.
Materials & methods:
Four trials in previously treated metastatic non-small-cell lung cancer with PD-L1 >1% were used comparing docetaxel with nivolumab, pembrolizumab and atezolizumab. Cure parameters related to a certain treatment class were assumed to share a common distribution.
Results:
Standard WMC NMA predicted cure rates were 0.03 (0.01; 0.07), 0.18 (0.12; 0.24), 0.07 (0.02; 0.15) and 0.03 (0.00; 0.09) for docetaxel, nivolumab, pembrolizumab and atezolizumab, respectively, with corresponding incremental life years (LY) of 3.11 (1.65; 4.66), 1.06 (0.41; 2.37) and 0.42 (-0.57; 1.68). The Bayesian hierarchical-WMC-NMA rates were 0.06 (0.03; 0.10), 0.17 (0.11; 0.23), 0.12 (0.05; 0.20) and 0.12 (0.03; 0.23), respectively, with incremental LY of 2.35 (1.04; 3.93), 1.67 (0.68; 2.96) and 1.36 (-0.05; 3.64).
Conclusion:
BH-WMC-NMA impacts incremental mean LYs and cost–effectiveness ratios, potentially affecting reimbursement decisions.