bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of serum transforming growth factor β1 with left ventricular hypertrophy in children with primary hypertension
Authors: Liu Yang , Lin Yao , Huang Xiaolan , Li Yaqi , Liu Yanyan , Shi Lin 
Published: September 2023

AbstractThe current study was designed to assess the association of serum transforming growth factor β1 (TGF-β1) with left ventricular hypertrophy (LVH) in children with primary hypertension. The present single-center prospective trial examined 182 patients diagnosed with primary hypertension in Children’s Hospital, Capital Institute of Pediatrics, between January 2021 and September 2022. Clinical data were analyzed, and ambulatory blood pressure was assessed for 24 h. LVH, the commonest subclinical cardiac feature of hypertension, was assessed by echocardiography. According to left ventricular geometry, cases were assigned to the LVH (n = 44) and normal geometry (n = 138) groups. Serum TGF-β1 amounts were quantitated by enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curves were established to analyze various variables for their predictive values in LVH. Among 182 children with primary hypertension, the concentrations of serum TGF-β1 were higher in stage 2 hypertension than in stage 1 (47.3 (38.8, 52.5) vs. 46.0 (38.6, 48.2) ng/L, Z =  − 2.376; P = 0.018). Additionally, serum TGF-β1 content showed a positive correlation with BP levels (P < 0.05). TGF-β1 amounts were significantly elevated in the LVH group compared with the normal geometry group (51.7 (46.1, 54.9) vs. 46.1 (38.7, 48.1) ng/L, Z =  − 4.324; P = 0.0000). Serum TGF-β1 content was positively associated with LVH (r = 0.321, P = 0.0000). Multivariable logistic regression analysis showed BMI (OR = 1.188, 95% CI 1.082–1.305; P = 0.0000) and elevated serum TGF-β1 content (OR = 1.063, 95% CI 1.016–1.113; P = 0.009) independently predicted LVH. A multivariable logistic regression model considering BMI and TGF-β1 content in LVH prediction was 0.771, with sensitivity and specificity of 72.7% and 70.3%, respectively.Conclusion: These data revealed an association of serum TGF-β1 with BP in children with primary hypertension. Serum TGF-β1 concentration was positively correlated with hypertensive cardiac damage. Serum TGF-β1 might constitute a valuable molecular marker for the prediction of LVH in children with primary hypertension. The combination of BMI and TGF-β1 has a certain diagnostic and predictive value for LVH in children with primary hypertension, which may provide a new reference index for early clinical identification of hypertensive cardiac damage.

What is Known:• Experimental and clinical data indicated TGF-β1 is involved in BP elevation.• TGF-β1 is positively correlated with LVMI and hypertrophy in adults.

What is New:• Our current study reveals an association of serum TGF-β1 with BP in children with primary hypertension.• Elevated serum TGF-β1 level is positively associated with LVH in children with primary hypertension.• The combination of BMI and TGF-β1 has a certain diagnostic and predictive value for LVH in children with primary hypertension.
The Complexity of the Hausdorff Distance
Authors: Jungeblut Paul , Kleist Linda , Miltzow Tillmann 
Published: September 2023

AbstractWe investigate the computational complexity of computing the Hausdorff distance. Specifically, we show that the decision problem of whether the Hausdorff distance of two semi-algebraic sets is bounded by a given threshold is complete for the complexity class $${ \forall \exists _{<}\mathbb {R}} $$

∀

∃
<

R

. This implies that the problem is -, -, $$\exists \mathbb {R} $$

∃
R

-, and $$\forall \mathbb {R} $$

∀
R

-hard.
Prevalence and genomic analysis of t203-like G9 (G9-VI) rotaviruses circulating in children with gastroenteritis in Beijing, China
Authors: Dong Hui-Jin , Liu Li-Ying , Jia Li-Ping , Zhao Lin-Qing , Jin Feng-Hua , Zhou Lin , Qian Yuan 
Published: September 2023

AbstractOur previous surveillance revealed that t203-like G9 (tentatively designated subtype G9-VI) rotaviruses re-emerged in 2010 in Beijing and rapidly prevailed over the G9-III subtype (the most common G9 subtype globally) and previously predominant G genotypes over the following two years. G9-VI belongs to the VP7 evolutionary lineage VI, which includes unusual and sporadic human rotaviruses from China (t203) and Japan. To obtain insight into the epidemiology, evolution, and transmission advantages of G9-VI rotavirus, we performed follow-up surveillance (2014-2017) and whole-genome analysis of 12 representative G9 strains. The results showed that the G9 genotype was predominant (77.4%), with a marked increase in prevalence (previously 43.5%). Within the G9 genotype, subtype G9-VI accounted for the majority (98.3%) of cases. The most prevalent P-genotype was P[8] (93.7%), within which subtype P[8]b was rare (0.7%). Phylogenetically, the G9-VI subtype strains in this study clustered closely with contemporary emerging human rotaviruses from many other countries in VP7 lineage VI, indicating that this subtype is capable of spreading globally. These currently emerging G9-VI rotaviruses formed a distinct monophyletic subcluster when compared to early G9-VI rotaviruses. Furthermore, four specific amino acid substitutions and synonymous codon substitutions were observed in the VP7 genes between the current G9-VI and globally common G9-III rotaviruses. The remaining nine genes of all of the analyzed representative G9 strains, whether G9-VI or G9-III, combined with the P[8]a, P[8]b, or P[6] genotype and exhibited the same Wa-like backbone constellation.
The crust shell and the edge beams of third-gradient continua in current and referential description
Authors: Krawietz Arnold 
Published: September 2023

AbstractA former publication has shown that some of the free boundary conditions of a third-gradient continuum can be interpreted as the equilibrium conditions of forces and moments of a crust shell and of edge beams. This was elaborated in the current (Eulerian) description. But it is obvious that a referential (Lagrangian) description of these physical phenomena must look very similar. This is, indeed, demonstrated in the paper at hand and disproves contrary claims in the literature. Moreover, the inductivist idea is omnipresent in the literature that a fictitious cut and a free surface show identical behaviour. But this is only correct with simple materials and not valid with higher gradient ones. We study a cube as a simple example where this wrong approach predicts the following absurd interaction between a subcube and the remainder of the cube: No actions at all appear on the fictitious cuts but there is one single force at the vertex of the subcube. Our findings do not depend on any specific constitutive assumption.
A survey on transactional stream processing
Authors: Zhang Shuhao , Soto Juan , Markl Volker 
Published: September 2023

AbstractTransactional stream processing (TSP) strives to create a cohesive model that merges the advantages of both transactional and stream-oriented guarantees. Over the past decade, numerous endeavors have contributed to the evolution of TSP solutions, uncovering similarities and distinctions among them. Despite these advances, a universally accepted standard approach for integrating transactional functionality with stream processing remains to be established. Existing TSP solutions predominantly concentrate on specific application characteristics and involve complex design trade-offs. This survey intends to introduce TSP and present our perspective on its future progression. Our primary goals are twofold: to provide insights into the diverse TSP requirements and methodologies, and to inspire the design and development of groundbreaking TSP systems.
A narrative review of potential drug treatments for nephritis in children with IgA vasculitis (HSP)
Authors: Williams Chloe E C , Lamond Megan , Marro Julien , Chetwynd Andrew J , Oni Louise 
Published: September 2023

AbstractImmunoglobulin A (IgA) vasculitis (IgAV, also known as Henoch-Schoenlein purpura, HSP) is the most common vasculitis of childhood. It usually presents with a simple, self-limiting disease course; however, a small subset of patients may develop kidney involvement (IgAV-N) which occurs 4–12 weeks after disease onset and is the biggest contributor to long-term morbidity. Treatment currently targets patients with established kidney involvement; however; there is a desire to work towards early prevention of inflammation during the window of opportunity between disease presentation and onset of significant nephritis. There are no clinical trials evaluating drugs which may prevent or halt the progression of nephritis in children with IgAV apart from the early use of corticosteroids which have no benefit. This article summarises the latest scientific evidence and clinical trials that support potential therapeutic targets for IgAV-N that are currently being developed based on the evolving understanding of the pathophysiology of IgAV-N. These span the mucosal immunity, B-cell and T-cell modulation, RAAS inhibition, and regulation of complement pathways, amongst others. Novel drugs that may be considered for use in early nephritis include TRF-budesonide; B-cell inhibiting agents including belimumab, telitacicept, blisibimod, VIS649, and BION-1301; B-cell depleting agents such as rituximab, ofatumumab, and bortezomib; sparsentan; angiotensin converting enzyme inhibitors (ACE-Is); and complement pathway inhibitors including avacopan, iptacopan, and narsoplimab. Further clinical trials, as well as pre-clinical scientific studies, are needed to identify mechanistic pathways as there may be an opportunity to prevent nephritis in this condition.

Key Points• Kidney involvement is the main cause of long-term morbidity and mortality in IgA vasculitis despite the current treatment recommendations.• The evolving understanding of the pathophysiology of IgA vasculitis is allowing exploration of novel treatment options which target underlying immune pathways.• Novel treatments currently being trialled in IgA nephropathy may have benefit in IgA vasculitis due to the similarities in the underlying pathophysiology, such as TRF-budesonide, B-cell modulators, and complement inhibitors.• Further studies, including clinical trials of novel drugs, are urgently needed to improve the long-term outcomes for children with IgA vasculitis nephritis.
Cues to individuality in Greylag Goose faces: algorithmic discrimination and behavioral field tests
Authors: Kleindorfer Sonia , Heger Benedikt , Tohl Damian , Frigerio Didone , Hemetsberger Josef , Fusani Leonida , Fitch W. Tecumseh , Colombelli-Négrel Diane 
Published: September 2023

AbstractCues to individuality, and the corresponding capacity for individual-level discrimination, can allow individually specific investment by conspecifics into offspring, partners, neighbors or competitors. Here we investigated possible cues to individuality via faces in an ancient avian lineage, the Greylag Goose (Anser anser). Konrad Lorenz could famously name each Greylag Goose in ‘his’ flock from a photograph. Confirming this anecdotal observation, we developed facial recognition software that can reliably (~ 97% accuracy) assign a goose face to a goose ID within a database, using bill morphology normalized during photo preparation. To explore conspecific detection of individuality cues, we erected life-size photos of geese and measured subjects’ responses to photos of themselves (unfamiliar goose), their partner, and another flock mate. Geese displayed significantly greater affiliative response to photos of their partners, providing evidence that geese can use two-dimensional images as cues to determine social category (partner/non-partner) and/or individual-level recognition. Our methods provide novel approaches to automatically detect and monitor geese and to test avian cognition. Our approach may also create new opportunities for species monitoring approaches more generally using photographic images and citizen-science engagement.
An origami like 3D patterned cellulose-based scaffold for bioengineering cardiovascular applications
Authors: Rodriguez Gabriela Melo , Trueb Donata , Köser Joachim , Schoelkopf Joachim , Gullo Maurizio 
Published: September 2023

AbstractIn this work we describe the manufacturing of cellulosic, cell compatible scaffolds with an inherent 3D origami crease pattern for applications in cardiac tissue engineering. Different cellulosic materials were studied, among them cotton linters, fibers obtained from eucalyptus, pine, spruce and lyocell. Formed sheets made of cotton linters were chosen for further study due to the highest biocompatibility and mechanical properties best suited for cardiomyocytes in wet and dry conditions: E - modulus of 0.8 GPa, tensile strength of 4.7 MPa and tensile strength in wet environment of 2.28 MPa. Cell alignment is desired to achieve directional contraction of the cardiac tissue, and several options were investigated to achieve fiber alignment, e.g. a dynamic sheet former and Rapid Köthen sheet former. Although the orientation was minimal, cells cultured on the cellulose fibers grew and aligned along the fibers. Origami inspired crease patterns were applied to the cellulose scaffolds in order to introduce directional flexibility beneficial for cardiac contraction. The transfer of a Miura-ori crease pattern was successfully applied in two ways: folding of the dried sheet between PET foils pre-formed in a 3D printed mold, and in situ wet fiber molding on a 3D-patterned mesh mounted in the sheet former’s sieve section. The latter approach enables upscaling for potential mass production.
“God is in Control”: Religious Coping in Sermons About the COVID-19 Pandemic in the Reformed Church in Zambia
Authors: Kroesbergen-Kamps Johanneke 
Published: September 2023

AbstractCoping is one of the mechanisms employed by people to deal with crises or disasters such as the global COVID-19 pandemic. The RCOPE, developed by Kenneth Pargament et al., is a quantitative scale to measure styles of religious coping. This article applies the RCOPE qualitatively to live-streamed sermons in the Reformed Church in Zambia, held in the two-month lockdown period in Zambia from the end of March to the end of May 2020. A total of 20 pastors contributed 134 sermons that were transcribed and analyzed using the full RCOPE. The results show that pastors in the RCZ mainly encourage their audiences to seek spiritual support, gain control over the situation, and give a positive meaning to the pandemic. The idea that God is in control is important behind all of these means of religious coping in the Zambian sermons. This qualitative analysis also discovered possible lacunae in the RCOPE questionnaire, especially concerning its applicability to evangelical forms of global Christianity, such as the lack of attention to God’s intervention and control.
Impact of timing of antiseizure medication withdrawal on seizure recurrence in glioma patients: a retrospective observational study
Authors: van der Meer Pim B. , Dirven Linda , Fiocco Marta , Vos Maaike J. , Kerkhof Melissa , Kouwenhoven Mathilde C.M. , van den Bent Martin J. , Taphoorn Martin J.B. , Koekkoek Johan A.F. 
Published: September 2023

Abstract
Background
Withdrawal of antiseizure medication treatment (ASM) can be considered after completion of antitumour treatment in glioma patients who no longer suffer from seizures. We compared the risk for recurrent seizures after ASM withdrawal between patients with short-term, medium-term versus long-term seizure freedom after antitumour treatment.

Methods
In this retrospective observational study, the primary outcome was time to recurrent seizure, from the starting date of no ASM treatment up to 36 months follow-up. Cox proportional hazards models were used to study the effect of risk factors on time to recurrent seizure. Stratification was done with information known at baseline. Short-term seizure freedom was defined as ≥ 3 months, but < 12 months; medium-term as 12–24 months; and long-term as ≥ 24 months seizure freedom from the date of last antitumour treatment.

Results
This study comprised of 109 patients; 31% (34/109) were in the short-term, 29% (32/109) in the medium-term, and 39% (43/109) in the long-term group. A recurrent seizure was experienced by 47% (16/34) of the patients in the short-term, 31% (10/32) in the medium-term, and 44% (19/43) in the long-term group. Seizure recurrence risk was similar between patients in the short-term group as compared to the medium-term (cause-specific adjusted hazard ratio [aHR] = 0.65 [95%CI = 0.29–1.46]) and long-term group (cause-specific aHR = 1.04 [95%CI = 0.52–2.09]).

Conclusions
Seizure recurrence risk is relatively similar between patients with short-term, medium-term, and long-term seizure freedom after completion of antitumour treatment.
Matheuristics approaches for the satellite constellation design problem
Authors: Mencarelli Luca , Floquet Julien , Georges Frédéric 
Published: September 2023

AbstractIn this paper, we propose two novel matheuristic algorithms, i.e., heuristics based on mathematical formulations of the problem, in order to find a good feasible solution to the satellite constellation design problem for discontinuous coverage with a constrained revisit time. This problem consists in searching for a constellation able to periodically observe several targets at the Earth surface with the smallest number of satellites achievable. A Feasibility Pump approach is described: we specifically adapt the Feasibility Pump procedure to our design problem and we report results highlighting the benefits of this approach compared to the base Mixed Integer Nonlinear Programming (MINLP) algorithm it is derived from. Then, we propose a second matheuristic based on the discretized Mixed Integer Linear Programming (MILP) formulation of the problem, which outperforms the plain MILP formulation.
How cultural competence is conceptualised, developed and delivered in pharmacy education: a systematic review
Authors: Jarrar Rawand , Lim Rosemary , Richardson Charlotte Lucy , Naqvi Atta Abbas , Rathbone Adam Pattison , Lau Wing Man 
Published: September 2023

Abstract
Background
It is important to have a pharmacy workforce that is culturally competent to recognise a patient’s health beliefs to improve medication adherence and reduce poor treatment outcomes.

Aim
This systematic review aimed to identify, critically appraise and summarise how cultural competency is conceptualised, developed and embedded in pre-qualification pharmacy education.

Method
Medline, Scopus, PsychInfo, Web of Knowledge, CINAHL, and Embase databases were searched for relevant papers published in English between January 2012 and December 2021, following PRISMA guidelines. Data from included papers were thematically analysed. Educational quality of papers was appraised using the GREET criteria. This systematic review was registered on PROSPERO, CRD42021295875.

Results
The review included 47 papers (46 studies) with 18 papers meeting ≥ 9 points on the GREET criteria thus considered of good educational quality. Forty papers focused on educational interventions implemented to pharmacy students only, the remaining included students from different health disciplines. Half of the educational interventions focused on cultural competence in general. Most educational interventions lasted over a week and 21 were compulsory. Cultural competence conceptualisation varied; a focus on knowledge about different cultures or on culturally competent behaviours or a continuum with knowledge at one end and behaviour at the other.

Conclusion
There is variation in how cultural competence is embedded in pharmacy programmes, which could be a reflection of the differences in how educators conceptualised cultural competence. Further research is needed to develop a unified understanding of the meaning of cultural competence and how it can be embedded in pharmacy education.
Digital innovation in family firms: The roles of non-family managers and transgenerational control intentions
Authors: Bornhausen Anna Maria , Wulf Torsten 
Published: September 2023

AbstractDigital innovation, i.e. the creation of products and services, processes, or business models on the basis of digital technology, represents a new innovation phenomenon that offers important opportunities, but also entails high risks. Family firm research argues that family firms generally possess a greater ability to innovate, but differ in their willingness to do so. We propose that with regard to digital innovation family firms rather face an “ability and willingness challenge”, i.e. they differ in their willingness and their ability to engage in digital innovation. We analyze two factors—non-family managers and transgenerational control intentions—that might help family firms overcome the ability and willingness challenge and that allows to explain heterogeneity among family firms in the adoption of digital innovation. An empirical, survey-based investigation of 104 German family firms supports our hypotheses. We contribute to the literature on digital innovation in family firms as well as on family firm professionalization.
Beyond generalization: a theory of robustness in machine learning
Authors: Freiesleben Timo , Grote Thomas 
Published: September 2023

AbstractThe termrobustnessis ubiquitous in modern Machine Learning (ML). However, its meaning varies depending on context and community. Researchers either focus on narrow technical definitions, such as adversarial robustness, natural distribution shifts, and performativity, or they simply leave open what exactly they mean by robustness. In this paper, we provide a conceptual analysis of the termrobustness, with the aim to develop a common language, that allows us to weave together different strands of robustness research. We define robustness as the relative stability of a robustness target with respect to specific interventions on a modifier. Our account captures the various sub-types of robustness that are discussed in the research literature, including robustness to distribution shifts, prediction robustness, or the robustness of algorithmic explanations. Finally, we delineate robustness from adjacent key concepts in ML, such as extrapolation, generalization, and uncertainty, and establish it as an independent epistemic concept.
Enhancing ultrafiltration performance for dairy wastewater treatment using a 3D printed turbulence promoter
Authors: Al-Tayawi Aws N. , Gulyás Nikolett Sz. , Gergely Gréta , Fazekas Ákos Ferenc , Szegedi Balázs , Hodúr Cecilia , Lennert József Richárd , Kertész Szabolcs 
Published: September 2023

AbstractDairy factories annually generate an increasing amount of wastewater, which can cause eutrophication due to high concentrations of amino acids and lipids. To address this issue, membrane technology has emerged as a promising solution, but membrane fouling remains a significant challenge, since it can cause decreased flux, decrease membrane rejection performance, and increased energy demand. This study aimed to reduce membrane fouling by integrated a three-dimensional printed (3DP) turbulence promoter into an ultrafiltration dead-end cell and varying stirring speeds. Two mathematical models, Hermia and resistance-in-series, were used to analyze the fouling process. According to both models, the cake layer formation model indicated the most prevalent fouling mechanism. Specific energy demand, permeate flux, membrane rejection, and membrane reversible and irreversible resistances were measured, calculated, and compared. The results suggest that the combination of an integrated 3DP turbulence promoter and high stirring speeds can effectively reduce membrane fouling in a dairy wastewater treatment module.