bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invariant family of leaf measures and the Ledrappier–Young property for hyperbolic equilibrium states
Authors: BEN OVADIA SNIR 
Published: December 2022

AbstractThe manifold M is a Riemannian, boundaryless, and compact manifold with
$\dim M\geq 2$
, and f is a
$C^{1+\beta }$
(
$\kern0.3pt\beta>0$
) diffeomorphism of M.
$\varphi $
is a Hölder continuous potential on M. We construct an invariant and absolutely continuous family of measures (with transformation relations defined by
$\varphi $
), which sit on local unstable leaves. We present two main applications. First, given an ergodic homoclinic class
$H_\chi (p)$
, we prove that
$\varphi $
admits a local equilibrium state on
$H_\chi (p)$
if and only if
$\varphi $
is ‘recurrent on
$H_\chi (p)$
’ (a condition tested by counting periodic points), and one of the leaf measures gives a positive measure to a set of positively recurrent hyperbolic points; and if an equilibrium measure exists, the said invariant and absolutely continuous family of measures constitute as its conditional measures. An immediate corollary is the local product structure of hyperbolic equilibrium states. Second, we prove a Ledrappier–Young property for hyperbolic equilibrium states: if
$\varphi $
admits a conformal family of leaf measures and a hyperbolic local equilibrium state, then the leaf measures of the invariant family (respective to
$\varphi $
) are equivalent to the conformal measures (on a full measure set). This extends the celebrated result by Ledrappier and Young for hyperbolic Sinai–Ruelle–Bowen measures, which states that a hyperbolic equilibrium state of the geometric potential (with pressure zero) has conditional measures on local unstable leaves which are absolutely continuous with respect to the Riemannian volume of these leaves.
Quantitative Heegaard Floer cohomology and the Calabi invariant
Authors: Cristofaro-Gardiner Daniel , Humilière Vincent , Mak Cheuk Yu , Seyfaddini Sobhan , Smith Ivan 
Published: December 2022

Abstract
We define a new family of spectral invariants associated to certain Lagrangian links in compact and connected surfaces of any genus. We show that our invariants recover the Calabi invariant of Hamiltonians in their limit. As applications, we resolve several open questions from topological surface dynamics and continuous symplectic topology: We show that the group of Hamiltonian homeomorphisms of any compact surface with (possibly empty) boundary is not simple; we extend the Calabi homomorphism to the group of hameomorphisms constructed by Oh and Müller, and we construct an infinite-dimensional family of quasi-morphisms on the group of area and orientation preserving homeomorphisms of the two-sphere.
Our invariants are inspired by recent work of Polterovich and Shelukhin defining and applying spectral invariants, via orbifold Floer homology, for links composed of parallel circles in the two-sphere. A particular feature of our work is that it avoids the orbifold setting and relies instead on ‘classical’ Floer homology. This not only substantially simplifies the technical background but seems essential for some aspects (such as the application to constructing quasi-morphisms).
Contra Teleology: Hegel on Subjective and Objective Purpose
Authors: Thompson Kevin 
Published: December 2022

AbstractHegel's system is not teleological. For a philosophy to be teleological, as I shall use the term, means that it takes the basic nature of the world itself or any foundational account of that world to be defined ultimately by final causality. Such a view has, of course, long stood as the dominant model for interpreting Hegel's system. This essay argues, to the contrary, that the accounts of Teleology and Life in the Science of Logic, and more precisely their analyses of what Hegel calls there subjective purpose and objective purpose, actually demonstrate this conception of teleology to be profoundly mistaken.The conventional reading of these sections is that they argue for two related claims: (1) that the means-ends relationship of extrinsic purposiveness—subjective purpose—is made possible by the intrinsic self-organizing process of intrinsic purposiveness; and (2) that intrinsic purposiveness—objective purpose—takes the basic structure of an organism, a natural purpose (Naturzweck), as its model, a model defined by final causality. I show this to be a deeply flawed interpretation. Hegel certainly shows that extrinsic purposiveness entails intrinsic purposiveness, but he does not conceive of intrinsic purposiveness, objective purpose, in terms of the final causality inherent in the model of a natural purpose. Rather, the systematic account of logical life argues that the activity of life must be understood as genus and this as a process of self-differentiation where the immanent and necessary unfolding of determinate negation itself, and itself alone, engenders the development without possessing or relating itself to any antecedent content. Hence, this austere thesis, rather than any form of final causality, is, as Hegel puts it, the truth of teleology, the nature of the absolute idea, and, as a result, Hegel's system is shown, at its very core, not to be teleological.
Getting to zero: Impact of a device to reduce blood culture contamination and false-positive central-line–associated bloodstream infections
Authors: Tompkins Lucy S. , Tien Vivian , Madison Alexandra N. 
Published: December 2022

AbstractObjective:To assess the impact of initial specimen diversion device (ISDD) on inpatient and emergency department blood culture contamination (BCC), central-line–associated bloodstream infection (CLABSI) standardized infection ratios (SIRs), and antibiotic administration.Design:Single-center quasi-experimental prospective cohort study wherein phlebotomists used traditional venipuncture with or without the ISDD while registered nurses (RNs) used traditional venipuncture.Method:BCC events among phlebotomists and RNs were observed and compared from March 17, 2019, through January 21, 2020, defined by contaminant detection in 1 of 4 bottles for matched sets or 1 of 2 bottles in both subsets for coagulase negative staphylococci. CLABSIs throughout this period were recorded and SIRs were calculated. Enhanced oversight took place through July 21, 2019, with chart review assessing antibiotic use for patients with possible BCC.Results:Overall, 24% of blood cultures obtained were from patients in intensive care. Phlebotomists using traditional venipuncture (n = 4,759) had a 2.3% BCC rate; phlebotomists using the ISDD (n = 11,202) had a 0% BCC rate. RNs drew 7,411 BCs with a 0.8% BCC rate. The CLABSI SIR was decreased from 1.103 in 2017 and 0.658 in 2018 to 0.439 in 2019. The CLABSI incidence was 33%–64% of predicted value for each 2019 quarter. This range fell to 18%–37% after the exclusion of likely false-positive results. Among 42 patients with possible BCC under enhanced oversight, 2 patients were treated with prolonged antibiotic courses.Conclusions:ISDD use by phlebotomists was associated with BCC reduction and reduced false-positive CLABSI results. This patient-care quality improvement could constitute sustainable antibiotic stewardship expansion.
Morphological evolution during the last hurrah of the trilobites: morphometric analysis of the Devonian asteropyginid trilobites
Authors: Martin Rene P. , Carranza Natalia López , LaVine Rhiannon J. , Lieberman Bruce S. 
Published: December 2022

AbstractThe Asteropyginae Delo, 1935 is a group of phacopid trilobites in the family Acastidae Delo, 1935 that has served as the focus for several studies due to their distinctive morphologies and diversity. However, despite an interest in these characteristic morphologies, there have been no studies that have examined this group using morphometric techniques. Our investigation utilized both geometric morphometric and elliptical Fourier methods to quantify the morphology of cephalic sclerites of asteropyginid specimens representing wide taxonomic sampling of the clade. We constructed a phylomorphospace that shows temporal and spatial patterns of phenotypic evolution within the framework of a novel tip-dated phylogenetic tree generated using Bayesian inference. We recovered similar patterns in disparity regardless of the morphometric approach. Both analyses illustrated a marked expansion into morphospace throughout the temporal range of the clade, peaking in disparity in the Emsian and with European taxa exhibiting the highest disparity in glabellar morphospace. Additionally, glabellar shape showed low phylogenetic signal and no major patterns in phylomorphospace. This study highlights the utility of employing different methodologies to quantitatively explore the disparity of fossil taxa. It also illustrates some of the patterns of morphological change occurring during one of the final and major evolutionary radiations within Phacopida.
Target pollen isolation using automated infrared laser-mediated cell disruption
Authors: Kaneshiro Ikuma , Igarashi Masako , Higashiyama Tetsuya , Mizuta Yoko 
Published: December 2022

Abstract
Single-cell analysis is important to understand how individual cells work and respond at the cell population level. Experimental single-cell isolation techniques, including dilution, fluorescence-activated cell sorting, microfluidics, and micromanipulation, have been developed in recent decades. However, such applications typically require large cell populations and skilled professionals. Additionally, these methods are unsuitable for sequential analysis before and after cell isolation. In this study, we propose a method for target cell isolation using automated infrared laser-mediated disruption of pollen grains in pollen populations. Germination of the target pollen was observed at the same location as that before laser irradiation, and germinated pollen grains were enriched in the cell population. Pollination of laser-irradiated bulk pollen populations also showed that the target pollen preferentially germinated on the stigma. This method is expected to facilitate physiological analyses of target cells at the single-cell level and effectively produce seeds derived from target pollen.
Sphingolipids and acylcarnitines are altered in placentas from women with gestational diabetes mellitus
Authors: Pinto Gabriela D. A. , Murgia Antonio , Lai Carla , Ferreira Carolina S. , Goes Vanessa A. , Guimarães Deborah de A. B. , Ranquine Layla G. , Reis Desirée L. , Struchiner Claudio J. , Griffin Julian L. , Burton Graham J. , Torres Alexandre G. , El-Bacha Tatiana 
Published: December 2022

AbstractGestational diabetes mellitus (GDM) is the most common medical complication of pregnancy and a severe threat to pregnant people and offspring health. The molecular origins of GDM, and in particular the placental responses, are not fully known. The present study aimed to perform a comprehensive characterisation of the lipid species in placentas from pregnancies complicated with GDM using high-resolution MS lipidomics, with a particular focus on sphingolipids and acylcarnitines in a semi-targeted approach. The results indicated that despite no major disruption in lipid metabolism, placentas from GDM pregnancies showed significant alterations in sphingolipids, mostly lower abundance of total ceramides. Additionally, very long-chain ceramides and sphingomyelins with twenty-four carbons were lower, and glucosylceramides with sixteen carbons were higher in placentas from GDM pregnancies. Semi-targeted lipidomics revealed the strong impact of GDM on the placental acylcarnitine profile, particularly lower contents of medium and long-chain fatty-acyl carnitine species. The lower contents of sphingolipids may affect the secretory function of the placenta, and lower contents of long-chain fatty acylcarnitines is suggestive of mitochondrial dysfunction. These alterations in placental lipid metabolism may have consequences for fetal growth and development.
Petrogenesis and tectonic implications of the early Mesozoic granitoids in the northern Alxa region, Central Asian Orogenic Belt
Authors: Zhao Xiaochen , Liu Chiyang , Wang Jianqiang , Niu Yazhuo , Huang Lei , Zhang Shaohua , Du Fangpeng , Peng Heng , Chen Yingtao , Peng Tao , Mao Zhengzheng 
Published: December 2022

AbstractThe northern Alxa region is located in the central segment of the southern Central Asian Orogenic Belt. Many controversies and deficiencies still exist regarding the magma source characteristics, petrogenesis and tectonic regimes during the late Palaeozoic – early Mesozoic period within this region. This study presents whole-rock compositions and zircon U–Pb and Lu–Hf isotopic data for three early Mesozoic I- and A-type granitic plutons occurring in the northern Alxa region. The Haerchaoenji and Chahanhada I-type granitoids yielded zircon206Pb–238U ages of 245 ± 5 Ma and 245 ± 2 Ma, respectively. The variable positive zircon ϵHf(t) values between +1.8 and +11.8, with young TDMages of 425–837 Ma, indicate that these I-type granitoids were mainly derived from juvenile crustal materials. The Wulantaolegai pluton has a zircon206Pb–238U age of 237 ± 2 Ma and is classified as having high-K calc-alkaline A-type affinity. Furthermore, the positive zircon ϵHf(t) values of the Wulantaolegai granite range from +3.3 to +8.7 with young TDMages of 545–778 Ma, suggesting the involvement of a juvenile crustal source as well. Furthermore, the major-element compositions of the Chahanhada and Wulantaolegai granites suggest the input of metasedimentary components. Geochemically, the Haerchaoenji and Chahanhada I-type granitoids show an arc affinity, while the Wulantaolegai granite exhibits a post-collisional affinity. However, with regional data, we suggest that the Haerchaoenji and Chahanhada I-type granitoids were also emplaced in a post-collisional setting, and the arc affinity was probably inherited from recycled subduction-related materials. These lines of evidence obtained in this study enable us to argue that the Palaeo-Asian Ocean in the central segment of the Central Asian Orogenic Belt closed before Middle Triassic time.
Bayesian Seismic Source Inversion With a 3‐D Earth Model of the Japanese Islands
Authors: Simutė Saulė , Boehm Christian , Krischer Lion , Gokhberg Alexey , Vallée Martin , Fichtner Andreas 
Published: December 2022

AbstractWe present probabilistic centroid‐moment tensor solutions inferred from the combination of Hamiltonian Monte Carlo sampling and a 3‐D full‐waveform inversion Earth model of the Japanese islands. While the former provides complete posterior probability densities, the latter allows us to exploit waveform data with periods as low as 15 s. For the computation of Green's functions, we employ spectral‐element simulations through the radially anisotropic and visco‐elastic model, leading to substantial improvements of data fit compared to layered models. Focusing on 13 Mw 4.8–Mw 5.3 offshore earthquakes with a significant non‐double‐couple (non‐DC) component, we simultaneously infer the centroid location, time and moment tensor without any a priori constraints on the faulting mechanism. Furthermore, we perform the inversions across several period bands, varying the minimum period between 15 and 50 s. Accounting for 3‐D Earth structure at shorter periods can increase the double‐couple (DC) component of an event, compared to the GCMT solution, by tens of percent. This suggests that non‐DC events in the GCMT catalog may result from unmodeled Earth structure and the related limitation to longer‐period data. We also observe that significant changes in source parameters, and the DC component in particular, may be related to only small waveform changes, thereby accentuating the importance of a reliable Earth model. Posterior probability density distributions become increasingly multimodal for shorter‐period data that provide tighter constraints on source parameters. This implies, in our specific case, that stochastic approaches to the source inversion problem are required for periods below ∼20 s to avoid trapping in local minima.
Fault Gouge Dating in the Spanish Pyrenees: Fault Ages, Thrust Propagation Sequence, Wall‐Rock Provenance, and Thermal Constraints
Authors: Haines Samuel H. , van der Pluijm Ben A. 
Published: December 2022

AbstractDating brittle faults by the growth of authigenic illite in fault gouge allows for direct testing of kinematic models of orogenic evolution, such as in‐sequence versus out‐of‐sequence thrusting, and the presence of orogenic “pulses” of deformation on multiple thrusts simultaneously. We present illite gouge ages from five thrust faults along the Ter and Freser rivers in the south‐eastern Pyrenees fold‐and‐thrust belt dated by Ar‐Ar methods. The ages show in‐sequence thrusting for the south‐eastern Pyrenees fold‐thrust belt during the Eocene and early Oligocene, ranging from 49.5 + 4.4 Ma for the inboard Freser Antiformal Stack to 31.9 ± 3.9 Ma for the frontal L’Escala Thrust. Foreland progression of ages is preserved, although overlapping of ages of the frontal thrusts permits the interpretation of a period of more rapid fault displacement around 35 Ma. Shortening rates for the Ter‐Freser section range from 1.2–2.7 km/my, with strain rates ranging from 7.0 × 10−16 s−1 to 1.6 × 10−15 s−1 The latest Paleozoic ages of the cataclastically derived component inferred from the gouge dating methodology are shown to be pooled 2M1 illite/mica ages of wall rock sediments and have geological meaning. These inferred mica ages of the thrust wallrocks in the southeastern Pyrenees indicate Hercynian‐age micas were deposited in the Southern Pyrenean foreland basin as early as the late Cretaceous. Previous thermochronometer and Δ47 temperatures from syn‐faulting calcite veins constrain temperature of clay gouge formation in the Ter‐Freser section at 50–210°C, with most likely temperatures of 50–160°C, consistent with previous studies.
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform
Authors: Arter William E. , Qi Runzhang , Erkamp Nadia A. , Krainer Georg , Didi Kieran , Welsh Timothy J. , Acker Julia , Nixon-Abell Jonathan , Qamar Seema , Guillén-Boixet Jordina , Franzmann Titus M. , Kuster David , Hyman Anthony A. , Borodavka Alexander , George-Hyslop Peter St , Alberti Simon , Knowles Tuomas P. J. 
Published: December 2022

AbstractThe assembly of biomolecules into condensates is a fundamental process underlying the organisation of the intracellular space and the regulation of many cellular functions. Mapping and characterising phase behaviour of biomolecules is essential to understand the mechanisms of condensate assembly, and to develop therapeutic strategies targeting biomolecular condensate systems. A central concept for characterising phase-separating systems is the phase diagram. Phase diagrams are typically built from numerous individual measurements sampling different parts of the parameter space. However, even when performed in microwell plate format, this process is slow, low throughput and requires significant sample consumption. To address this challenge, we present here a combinatorial droplet microfluidic platform, termed PhaseScan, for rapid and high-resolution acquisition of multidimensional biomolecular phase diagrams. Using this platform, we characterise the phase behaviour of a wide range of systems under a variety of conditions and demonstrate that this approach allows the quantitative characterisation of the effect of small molecules on biomolecular phase transitions.
A large-scale view of marine heatwaves revealed by archetype analysis
Authors: Chapman Christopher C. , Monselesan Didier P. , Risbey James S. , Feng Ming , Sloyan Bernadette M. 
Published: December 2022

AbstractMarine heatwaves can have disastrous impacts on ecosystems and marine industries. Given their potential consequences, it is important to understand how broad-scale climate variability influences the probability of localised extreme events. Here, we employ an advanced data-mining methodology, archetype analysis, to identify large scale patterns and teleconnections that lead to marine extremes in certain regions. This methodology is applied to the Australasian region, where it identifies instances of anomalous sea-surface temperatures, frequently associated with marine heatwaves, as well as the broadscale oceanic and atmospheric conditions associated with those extreme events. Additionally, we use archetype analysis to assess the ability of a low-resolution climate model to accurately represent the teleconnection patterns associated with extreme climate variability, and discuss the implications for the predictability of these impactful events.
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system
Authors: Lolo Fidel-Nicolás , Walani Nikhil , Seemann Eric , Zalvidea Dobryna , Pavón Dácil María , Cojoc Gheorghe , Zamai Moreno , Viaris de Lesegno Christine , Martínez de Benito Fernando , Sánchez-Álvarez Miguel , Uriarte Juan José , Echarri Asier , Jiménez-Carretero Daniel , Escolano Joan-Carles , Sánchez Susana A. , Caiolfa Valeria R. , Navajas Daniel , Trepat Xavier , Guck Jochen , Lamaze Christophe , Roca-Cusachs Pere , Kessels Michael M. , Qualmann Britta , Arroyo Marino , del Pozo Miguel A. 
Published: December 2022

AbstractIn response to different types and intensities of mechanical force, cells modulate their physical properties and adapt their plasma membrane (PM). Caveolae are PM nano-invaginations that contribute to mechanoadaptation, buffering tension changes. However, whether core caveolar proteins contribute to PM tension accommodation independently from the caveolar assembly is unknown. Here we provide experimental and computational evidence supporting that caveolin-1 confers deformability and mechanoprotection independently from caveolae, through modulation of PM curvature. Freeze-fracture electron microscopy reveals that caveolin-1 stabilizes non-caveolar invaginations—dolines—capable of responding to low-medium mechanical forces, impacting downstream mechanotransduction and conferring mechanoprotection to cells devoid of caveolae. Upon cavin-1/PTRF binding, doline size is restricted and membrane buffering is limited to relatively high forces, capable of flattening caveolae. Thus, caveolae and dolines constitute two distinct albeit complementary components of a buffering system that allows cells to adapt efficiently to a broad range of mechanical stimuli.
Representation of nuclear magnetic moments via a Clifford algebra formulation of Bohm’s hidden variables
Authors: Santilli Ruggero Maria , Sobczyk Garret 
Published: December 2022

AbstractIn this paper, we outline the research conducted by the first named author and his associates on the axiom-preserving, thus isotopic completion of quantum mechanics into hadronic mechanics according to the historical legacy by A. Einstein, B. Podolsky and N. Rosen that quantum mechanics is not a complete theory and review the ensuing exact representation of the magnetic moment and spin of the Deuteron in its ground state thanks to the isotopic completion of Pauli’s matrices with an explicit and concrete content of D. Bohm’s hidden variable$$\lambda$$
λ
. We then outline the independent studies conducted by the second named author on the representation of the conventional Pauli’s matrices via geometric Clifford algebras. We finally show that the combination of the two studies allows a mathematically rigorous, numerically exact and time invariant geometric representation of the magnetic moment, spin and hidden variable of the Deuteron in its ground state.