bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of soil management on carbon stock and soil aggregation in a natural recovery area and surrounding systems, Brazil
Authors: Alcântara Laiza Coelho , Neves Isabela , Rosset Jean Sérgio , Ozório Jefferson Matheus Barros , Panachuki Elói , Castilho Selene Cristina Pierri , Schiavo Jolimar Antonio , Farias Paulo Guilherme da Silva , Souza Camila Beatriz da Silva , Santos Wesley Vieira , Marra Leandro Marciano 
Published: September 2023

Abstract

This study aimed to quantify total organic carbon (TOC), carbon of humic substances (HS), and their stocks and evaluate the soil structural stability of areas with different uses under sandy loam soil textureSoil samples were collected from three areas and a reference area: Permanent Pasture (PP), No-Till (NT), Private Natural Heritage Reserve in the process of natural regeneration (RPPN) and Native Forest (FN). Dry mass analysis, carbon stock quantification, chemical fractionation of soil organic matter and soil aggregation were carried out. The NF area had the highest deposition of ML. The PP and NT areas had the highest Bd. TOC and Stock-C contents were higher in PNHR, followed by NF, and STRATI was also higher in the regeneration area, and ΔStock-C was positive only in this area. The NT, PNHR, and NF areas had a higher proportion of C-FA than C-HA, but the fraction with the highest representation in all areas was C-HUM. The PP, PNHR, and NF areas obtained the best aggregate stability indicators, such as WMD, GMD, SI, and OLev, as well as a higher proportion of macroaggregates, with the NT area having low aggregate stability. In general, recovery of C contents was observed in recent years in the area of PNHR, leading to a greater storage of C, which shows a quantitative recovery of C in the soil in this area after four years of natural regeneration. Furthermore, the PP and NT areas present a lower capacity for C sequestration, mainly due to the management conditions imposed on the areas.
PD-1 inhibitor combined with chemotherapy or Lenvatinib in advanced gallbladder cancer: A retrospective comparative study
Authors: Song Hao , Ma Hong-yan , Xiao Yi , Liang Xiao-lu , Liu Guo-hua , Xu Hao , Tan Xiao-yu , Liu Bin 
Published: September 2023

Abstract
Background
Gallbladder cancer (GBC) is a refractory primary cancer. Some patients are prone to recurrence even after surgical resection. Chemotherapy is the most common non-surgical treatment used in these patients. The emergence of PD-1(programmed cell death protein 1) inhibitors and targeted therapy have provided an additional option for many advanced tumors.
Methods
This was a retrospective study of patients with advanced GBC treated at the Eastern Hepatobiliary Surgery Hospital between June 2019 and June 2022. The patients receiving a PD-1 inhibitor(Tislelizumab) with chemotherapy or with Lenvatinib were retrospectively analyzed. RECIST1.1 (response evaluation criteria in solid tumors) was used as the efficacy evaluation standard. The overall survival(OS), progression-free survival(PFS), objective response rate(ORR), disease control rate(DCR), tumor marker CA199 were evaluated.
Results
61 patients with advanced GBC were included in the study. Including 32 patients received Tislelizumab plus GS(Gemcitabine and TS-1) chemotherapy, 29 patients received Tislelizumab combined with lenvatinib. Tislelizumab plus GS group median overall survival(OS) and progression-free survival(PFS) were 19.64 ± 11.81 (95% CI: 16.47–25.20) and 15.44 ± 13.42 (95% CI: 12.08–22.25) months. Tislelizumab plus Lenvatinib group median overall survival and progression-free survival were 13.06 ± 9.41 (95% CI: 9.72–16.63) and 10.34 ± 10.03 (95% CI: 6.56–14.13) months. The objective response rate, disease control rate were 59.38%, 81.3% with a Tislelizumab plus GS group, signifcantly longer than plus Lenvatinib group. Treatmentrelated adverse events were similar between two group.
Conclusion
Tislelizumab plus GS chemotherapy provides a safe and more efficient treatment option for advanced GBC patients.
The radial solutions for a class of Kirchhoff type equation with variable exponent
Authors: Chu Changmu , Yu Ying 
Published: September 2023

Abstract
This paper is concerned with the following Kirchhoff type equation\begin{equation*}\label{eq0.1}\left\{\begin{array}{ll}-(a+b\int_{B}|\nabla u|^{2}dx)\Delta u=u^{q(x)-1}, &\ \ \mbox{in}\ \ B,\\ u\geq0, &\ \ \mbox{in}\ \ B,\\ u=0, &\ \\mbox{in}\ \ \partial B, \end{array} \right.\end{equation*}where $a\geq0$, $b>0$ are real numbers and $B$ is the unit ball in $\R^3$, $q(x)=q(|x|)$ is a continuous radial function satifying $2<\mathop {\min }\limits_{x \in \overline{B}}q(x)=q_-<4
4$. By means of variational methods and a priori estimate, we prove the existence and multiplicity of radial solutions to this problem.
Mathematics Subject Classification 2010: 35J20, 35J62, 35Q55.
Exploring wild, underutilized, and neglected edible plants in West Java, Indonesia: Ethnobotanical assessment, use trends, and potential for improved nutrition
Authors: Rahayu Yen Yen Sally , Dwiartama Angga , Rosleine Dian , Irsyam Arifin Surya Dwipa 
Published: September 2023

Abstract
Background
As one of the world’s biodiversity hotspots, Indonesia contains over 19,000 plant species, including wild, underutilized, and neglected edible plants (WUNEPs). These WUNEPs complement people’s diets and substitute for common vegetables, particularly in rural areas. However, in West Java, the biodiversity of WUNEPs is declining, which coincides with public health issues related to malnutrition. Because they often contain higher levels of micronutrients than domesticated crops, WUNEPs can be used as a healthy dietary alternative, especially given the growing prevalence of micronutrient deficiency and diet-related diseases among the Indonesian population. Despite the potential benefits of addressing these issues, limited research has been conducted on this topic. This study aims to document the diversity of WUNEPs in rural West Java, assess communities’ perceptions regarding their availability and importance, and determine factors influencing their consumption.
Methods
The ethnobotanical surveys involved interviewing 20 purposively selected key informants with sound traditional knowledge of useful WUNEPs. The nutritional compositions of these foods, obtained from literature and analysis, are discussed, as is their contribution to the recommended dietary allowances of certain nutrients for men and women. Information regarding the perceptions, attitudes, and correlates of WUNEP consumption was collected through a semi-structured questionnaire from 107 Sundanese women in three villages in the region.
Results
The study documented 53 species of WUNEPs from 27 families, including leafy vegetables, spices/condiments, fruits, roots/tubers, and flowers. The documented WUNEPs have superior nutritional value and provide essential nutrients compared to common vegetables. Most respondents agreed that consumption has declined due to reduced availability, a lack of knowledge regarding the identification and nutritional benefits of the species, time constraints, and a preference for improved varieties. The main motivations for using WUNEPs were their availability as free food, medicinal value, nostalgic value, and preferred taste. WUNEP consumption frequency among the studied Sundanese communities is not associated with age, body mass index, dietary diversity, occupation, or household expenditure.
Conclusions
WUNEPs can potentially improve diets and create a more sustainable food system. As natural resources decline, promoting biodiversity for improved nutrition and ensuring their sustainable use is important. This requires collaboration among communities, governments, and stakeholders.
Real-world use of multigene signatures in early breast cancer: differences to clinical trials
Authors: Licata Luca , De Sanctis Rita , Vingiani Andrea , Cosentini Deborah , Iorfida Monica , Caremoli Elena Rota , Sassi Isabella , Fernandes Bethania , Gianatti Andrea , Guerini-Rocco Elena , Zambelli Claudia , Munzone Elisabetta , Simoncini Edda Lucia , Tondini Carlo , Gentilini Oreste , Zambelli Alberto , Pruneri Giancarlo , Bianchini Giampaolo 
Published: September 2023

Abstract
Purpose
In Italy, Lombardy was the first region to reimburse multigene assays (MGAs) for patients otherwise candidates for chemotherapy. This is a real-world experience of MGAs usage in six referral cancer centers in Lombardy.
Methods
Among MGAs, OncotypeDX (RS) was used in 97% of cases. Consecutive patients tested with OncotypeDX from July 2020 to July 2022 were selected. The distribution of clinicopathologic features by RS groups (low-RS: 0–25, high-RS: 26–100) was assessed using chi-square and compared with those of the TAILORx and RxPONDER trials.
Results
Out of 1,098 patients identified, 73% had low-RS. Grade and Ki67 were associated with RS (p < 0.001). In patients with both G3 and Ki67 > 30%, 39% had low-RS, while in patients with both G1 and Ki67 < 20%, 7% had high-RS. The proportion of low-RS in node-positive patients was similar to that in RxPONDER (82%vs83%), while node-negative patients with low-RS were significantly less than in TAILORx (66%vs86%, p < 0.001). The distribution of Grade was different from registration trials, with more G3 and fewer G1 (38% and 3%) than in TAILORx (18% and 27%) and RxPONDER (10% and 24%) (p < 0.001). Patients ≤ 50 years were overrepresented in this series (41%) than in TAILORx and RxPONDER (31% and 24%, respectively) (p < 0.001) and, among them, 42% were node-positive.
Conclusions
In this real-world series, OncotypeDX was the test almost exclusively used. Despite reimbursement being linked to pre-test chemotherapy recommendation, almost 3/4 patients resulted in the low-RS group. The significant proportion of node-positive patients ≤ 50years tested indicates that oncologists considered OncotypeDX informative also in this population.
Exploring the Overlap: Comparing STORGIS and ONETOR data between 1950 and 1989
Authors: Schroder Zoe , Fricker Tyler 
Published: September 2023

Abstract

The current understanding of tornado climatology centers on the Storm Prediction Center's tornado database (ONETOR) which dates back to 1950. To understand tornado climatology before this date, a secondary database (STORGIS) of digitized tornado records over the period 1880–1989 are used. Here, the ONETOR database and STORGIS data set are compared for individual tornadoes and outbreaks with six or more F2+ tornadoes during the overlapping years of 1950 to 1989. For the study period, there are more individual tornado reports in the ONETOR database relative to the STORGIS data set. While both databases suggest a similar broad-scale understanding of tornado climatology spatially and by decade, month, and year, there is a statistically significant difference between the two databases with regards to the total number of reports over the study period. For the study period, there are more tornado outbreaks in the ONETOR database relative to the STORGIS data set. In total, more than 94% of the missing outbreaks in the STORGIS data set are weaker outbreaks with ten or less tornadoes. While the general spatial and temporal patterns of the number and size of tornado outbreaks is similar between the STORGIS data set and ONETOR database, there is a statistically significant difference in the total number and average number of tornado outbreaks between each database. These results herein indicate that while the STORGIS data set is representative of large-scale patterns of F2+ tornado behavior in the United States, it cannot be used synonymously with the ONETOR database without additional statistical methods or context.
NMR fingerprinting of conventional and genetically modified soybean plants with AtAREB transcription factors
Authors: Coutinho Isabel , Facchinatto William , Mertz-Hernning Liliane Marcia , Viana Américo José , Marin Silvana Regina , Santagneli Silvia Helena , Nepomuceno Alexandre , Colnago Luiz Aberto 
Published: September 2023

Abstract
Drought stress impacts soybean yield and physiological processes. However, the insertion of the activated form of the AtAREB1 gene in the soybean cultivar BR16, which is sensitive to water deficit improved the drought response of the genetically-modified plants under glasshouse conditions. Thus, in this study used 1H NMR in solution and solid-state NMR to investigate the response of genetically modified soybean overexpressing AREB under water deficiency conditions. We achieved that drought-tolerant soybean yields high content of amino acids isoleucine, leucine, threonine, valine, proline, glutamate, aspartate, asparagine, tyrosine and phenylalanine after twelve days of drought stress conditions, as compared to drought-sensitive soybeans under same conditions. Specific target compounds, including sugars, organic acids and phenolic compounds, were identified as involved in controlling sensitive soybean during the vegetative stage. Solid-state NMR was used to study the impact of drought stress on starch and cellulose content in different soybean genotypes. The findings provide insights into the metabolic adjustments of soybean overexpressing AREB transcription factors in adapting to dry climates. This study presents novel NMR techniques for investigating the metabolome of transgenic soybean plants in response to water deficit. The approach allowed for identification of physiological and morphological changes in drought-resistant and drought-tolerant soybean tissues. The findings indicate that drought stress significantly alters micro and macromolecular metabolism in soybean plants. Differential responses were observed among roots and leaves, as well as drought-tolerant and drought-sensitive cultivars, highlighting the complex interplay between overexpressed transcription factors and drought stress in soybean plants.
Dose-dependent effect and effective dose of nefopam to prevent catheter-related bladder discomfort in patients undergoing transurethral ureteroscopic lithotripsy: a retrospective case-control observational study
Authors: Lee Seo Yeon , Kim Young Uk , Lee Ju-Yeun , Kim Wook Hyun , Cho Hyung Rae 
Published: September 2023

Abstract
Background
Patients with Foley catheter may experience catheter-related bladder discomfort (CRBD) after surgery. Previous studies have indicated that nefopam can reduce the incidence and severity of CRBD; however, they could not compare dose-dependent effects (20 mg vs. 40 mg). Therefore, we aimed to investigate the dose-dependent effects, effective dose of nefopam for CRBD, and the incidence of side effects.
Methods
From August 2016 to December 2022, we reviewed the electronic medical records of patients aged 18–70 years with American Society of Anesthesiologists physical status I-III who underwent elective transurethral ureteroscopic lithotripsy under general anesthesia. Patients were either administered premedication to prevent CRBD (intravenous nefopam 20 mg, group N20, or 40 mg, group N40) or not (group C).
Results
The incidence of CRBD were 85.7% in Group C, 81.3% in Group N20, and 24.3% in Group N40. There was a significant difference in the incidence between the groups (P = 0.0034). As the dose of nefopam increased, the incidence of CRBD decreased linearly, and the difference was statistically significant (P = 0.002). In the trend test, severity also decreased as the dose of nefopam increased, which was statistically significant (P < 0.001). Evaluation of hemodynamic stability during surgery and postoperative nausea and vomiting showed no significant differences among the three groups.
Conclusions
Nefopam 40 mg reduced both the incidence and severity of CRBD compared to the control group.
Trial registration number:
ID- KCT0008381 (https://trialsearch.who.int/Trial2.aspx?TrialID=KCT0008381)
Date of registration – 2023-04-25
Assessing the sustainability of university information systems using the D&amp;M IS Success Model
Authors: Haimeng Wen , Hua Zhang , Meng Chen , Tengwei Yu , Yougen Xu 
Published: September 2023

Abstract
The majority of prominent universities globally have either established or are currently in the process of establishing information systems (ISs) that incorporate a range of applications. Nonetheless, a significant proportion lacks a clear comprehension of the sustainability success of their University Information Systems (UIS). On the basis of the D&M Model, a revised measurement model for assessing the sustainability of UIS along three dimensions is proposed: quality, satisfaction, as well as usage intention. Furthermore, the findings indicate substantial support for eight out of twelve hypothesized relationships among the sustainability variables. Particularly, frequency of use is significantly correlated with users' perceptions of system quality and usage intention. Based on our analysis, it has been indicated that both system quality and process quality play crucial roles in determining the intention to use and satisfaction of users of UIS, which are fundamental for attaining long-term sustainability. Notwithstanding, information quality may not be as remarkable, while service support quality only has a minor impact on user satisfaction.
Effect of Synthesized Lignin-Based Flame Retardant Liquid on the Flame Retardancy and Mechanical Properties of Cotton Textiles
Authors: Li Maksym , M.N. Prabhakar , Song Jung Il 
Published: September 2023

Abstract

The flammability of cotton is a significant concern for technical applications, prompting ongoing research into solutions to mitigate this risk. Traditional flame-retardant methods utilizing acid-based approaches are complex and can negatively affect the mechanical properties of textiles. To address these challenges, this study focuses on developing a liquid bio-based flame retardant (LBF) utilizing a lignin-silica-based liquid (LSL) extracted from rice husk (RH) and 9, 10-Dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO). A one-pot dip-coating technique is utilized to treat cotton with the LSL, and the flammability and mechanical properties of the treated cotton are subsequently tested. Fourier-transform infrared spectroscopy (FTIR) confirms the covalent bond formation of the LSL with DOPO and the hydrogen bond formation of the LBF with cotton. Scanning electron microscopy (SEM) confirms the uniformity of the coating. The experimental results demonstrate that the treated cotton exhibits self-extinguishing behavior during a vertical burning test (VBT), with a 78% reduction in peak heat release and a 65% reduction in total heat released during pyrolysis combustion flow calorimetry. Surprisingly, the treatment also improves the tensile behavior of the cotton by 21.7% and thermal stability by producing a protective char layer that accounted for 36.9% of the final residue. This study provides a promising approach for improving the flame resistance and mechanical strength of cotton for technical applications.
On computable numberings of families of Turing degrees
Authors: Faizrahmanov Marat 
Published: September 2023

Abstract
In this work, we study computable families of Turing degrees introduced and first studied by Arslanov and their numberings. We show that there exist finite families of Turing c.e. degrees both those with and without computable principal numberings and that every computable principal numbering of a family of Turing degrees is complete with respect to any element of the family. We also show that every computable family of Turing degrees has a complete with respect to each of its elements computable numbering even if it has no principal numberings. It follows from results by Mal’tsev and Ershov that complete numberings have nice programming tools and computational properties such as Kleene’s recursion theorems , Rice’s theorem, Visser’s ADN theorem, etc. Thus, every computable family of Turing degrees has a computable numbering with these properties. Finally, we prove that the Rogers semilattice of each such non-empty non-singleton family is infinite and is not a lattice.
MSC Classification: 03D45 , 03D25 , 03D30
Breastfeeding experience, barriers, and facilitators among mothers of vulnerable low birth weight infants in Amhara Region, Ethiopia: a qualitative exploratory study
Authors: Ekwueme Moses Collins , Tesfaye Yihenew Alemu , Biza Heran , Belew Mulusew Lijalem , Asefa Meseret , Asnakew Destaw , Gobezayehu Abebe Gebremariam , Cranmer John N. , Young Melissa Fox 
Published: September 2023

Abstract
Introduction: Globally, 15% - 20% of all live births are low birthweight (LBW) newborns, and many mothers with LBW newborns experience feeding difficulties. Concrete efforts to understand and mitigate the barriers to breastfeeding among this vulnerable group are urgently needed.
Methods:Mother-newborn pairs were recruited from 8 facilities from the government’s Saving Little Lives initiative in Amhara Region, Ethiopia. We conducted a qualitative study using in-depth interviews among 30 mothers of LBW newborns (10 with very low birthweight [VLBW, <1500 gm]; 8 with LBW [<2000 gm] who experience breastfeeding difficulties, and 12 without difficulties). The interviews were analyzed using thematic analysis to describe the breastfeeding barriers and facilitators for mothers with and without feeding difficulties.
Results: Despite strong intentions to exclusively breastfeed during pregnancy and knowledge of breastfeeding benefits, many mothers of LBW newborns had difficulties initiating and continuing breastfeeding while in-patient. Self-reported insufficient milk (SRIM), suboptimal breastfeeding support in hospitals, prolonged mother-newborn separation in Neonatal Intensive Care Units (NICUs), and limited knowledge of effective feeding techniques (limited antenatal and postnatal care education) were the most common barriers. Further, mothers with multiple births reported greater feeding difficulties; they were more likely to adopt formula feeding compared to those with single births. The primary facilitators of LBW breastfeeding were the synergy between health workers (mainly women health workers) and mothers, mothers’ peer counseling, and family support. However, health worker support varied widely across facilities.
Conclusion:The findings from this study provide contextual insights into maternal LBW breastfeeding barriers and facilitators of successful and sustained breastfeeding. For example, creating NICU expectations to minimize maternal-newborn separation, targeting neonates’ feeding support for mothers with VLBW newborns and/or multiple births, and designing a standardized protocol for LBW nutritional support to guide health worker support are critically needed.