bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new species of Ferulago (Apiaceae) from Türkiye
Authors: HAMZAOĞLU ERGİN 
Published: January 2025

Some interesting Ferulago (Apiaceae) specimens with long stems, 7–9 mm long bracts, and 8–11 mm wide mericarps were collected from Horasan District (Erzurum Province, Türkiye). At first glance, the specimens resembled the species Ferulago setifolia (sect. Eutaenia) as a habit. However, through a detailed examination, it was determined that there were some differences. Based on these differences, the specimens are presented to the scientific world as a new species named “Ferulago turcica”. The most obvious attributes that separate the new species from Ferulago setifolia, that is the closest taxon, are: blades of basal leaves triangular in outline and 3-pinnatisect (not linear-lanceolate and (3-)4-pinnatisect); terminal lobes of basal leaves 1–3 mm long and apiculate at apex (not 5–8(–12) mm long and setaceous-filiform at apex); bracts oblong and 7–9 mm long (not linear-lanceolate and 7–17 mm long); pedicels 9–14 and 3–6 mm long (not 8–10 and 7–11 mm long); mericarps 9–11 mm wide and broadly obovate-elliptic (not 7–8 mm wide and oblong-elliptic); epicuticular wax on the mericarp body sparsely irregular (not dense irregular). This study provided an elucidation outlining the attributes of the newly discovered species, complemented by photographic evidence and an overview of its broader ecological inclinations.
Analysis methods for covariate-constrained cluster randomized trials with time-to-event outcomes
Authors: Crisp Amy M. , Halloran M. Elizabeth , Hitchings Matt D. T. , Longini Ira M. , Dean Natalie E. 
Published: January 2025

Abstract

Background
Cluster randomized trials, which often enroll a small number of clusters, can benefit from constrained randomization, selecting a final randomization scheme from a set of known, balanced randomizations. Previous literature has addressed the suitability of adjusting the analysis for the covariates that were balanced in the design phase when the outcome is continuous or binary. Here we extended this work to time-to-event outcomes by comparing two model-based tests and a newly derived permutation test. A current cluster randomized trial of vector control for the prevention of mosquito-borne disease in children in Mexico is used as a motivating example.

Methods
We assessed type I error rates and power between simple randomization and constrained randomization using both prognostic and non-prognostic covariates via a simulation study. We compared the performance of a semi-parametric Cox proportional hazards model with robust variance, a mixed effects Cox model, and a permutation test utilizing deviance residuals.

Results
The permutation test generally maintained nominal type I error—with the exception of the unadjusted analysis for constrained randomization—and also provided power comparable to the two Cox model-based tests. The model-based tests had inflated type I error when there were very few clusters per trial arm. All three methods performed well when there were 25 clusters per trial arm, as in the case of the motivating example.

Conclusion
For time-to-event outcomes, covariate-constrained randomization was shown to improve power relative to simple randomization. The permutation test developed here was more robust to inflation of type I error compared to model-based tests. Gaining power by adjusting for covariates in the analysis phase was largely dependent on the number of clusters per trial arm.
Safety and efficacy of intravenous thrombolysis: a systematic review and meta-analysis of 93,057 minor stroke patients
Authors: Moawad Mostafa Hossam El Din , Salem Talal , Alaaeldin Anas , Elaraby Youssef , Awad Peter D. , Khalifa Amr Ahmed , Naggar Ahmed El , Mohamed Khaled Ashraf , Elhalal Mohamed , Badr Mostafa , Abdelnaby Ramy 
Published: January 2025

Abstract

Background
The definition of minor ischemic stroke (MIS) is a topic of debate, however, the most accepted definition is a stroke with National Institutes of Health Stroke Scale (NIHSS) ≤ 5. Intravenous thrombolysis (IVT) is a crucial treatment option for acute ischemic stroke (AIS) including: alteplase, recombinant human tissue-type plasminogen activator (r-tPA), and the recently approved tenecteplase. However, there is a debate regarding its safety and efficacy. Therefore, our objective was to determine the safety and efficacy of IVT in treating minor stroke patients (NIHSS ≤ 5).

Methods
Using the search strategy assigned which was based on three keywords: “mild” or “minor”, “stroke”, and “intravenous thrombolysis”, we searched for eligible articles on PubMed, Web of Science, Embase, and Scopus from inception till 10th January 2024. We conducted this meta-analysis using the random effect model to account for the heterogeneity among the studies. For the dichotomous variables, we calculated the odds ratio (OR) from the event and total of these variables. While for the continuous variables, we calculated the mean difference (MD) of these variables. Pooling of OR for the occurrence of events was also conducted.

Results
A total of 21 articles with 93,057 patients with MIS were included. The mean age of the participants ranged from 62.3 to 79.6. Most of the included patients had comorbidities such as hypertension, diabetes, previous stroke, smoking, atrial fibrillation, and hyperlipidemia. Of these, 10,850 received IVT while 82,207 did not. The use of IVT was statistically significant associated with 90-day modified Rankin score (mRs) 0–1 when compared with control with OR of 1.67 (95%CI: 1.46, 1.91, p < 0.00001) and was statistically significantly associated with improvement of NIHSS on discharge with OR of 2.19 (95%CI: 1.56, 3.08, p < 0.00001). In terms of safety outcomes, IVT has proven a safe profile, as there was no significant difference in intracranial hemorrhage (ICH) and mortality rates between the IVT and control groups with OR of 1.75 (95CI: 0.95, 3.23, p = 0.07) and 0.93 (95%CI: 0.77, 1.11, p = 0.41), respectively.

Conclusion
Although some studies have not found any benefits of IVT in MIS patients, a substantial body of literature strongly endorses IVT as an effective and safe treatment for MIS. IVT has been shown to improve the mRs and NIHSS scores at the 90-day mark without an increased risk of ICH or mortality.
Positive real-time PCR in pneumococcal meningitis 12 hours after initiation of antibiotic therapy – case report
Authors: Thunstedt Cem , Palleis Carla , Wischmann Johannes , Heck Suzette , Dimitriadis Konstantinos , Klein Matthias 
Published: January 2025

Abstract

Background
Purulent meningitis poses a significant clinical challenge with high mortality. We present the case of a 54-year-old female transferred to our emergency department with suspected bacterial meningitis, later diagnosed as an Austrian syndrome.

Case presentation
The patient exhibited subacute somnolence, severe headache, nausea and fever. Initial antibiotic therapy was initiated without successful lumbar puncture. Upon arrival at our hospital, she presented with septic shock, meningism, and respiratory symptoms. Lumbar puncture revealed cloudy cerebrospinal fluid with elevated cell count, protein, and low glucose. While blood and CSF cultures remained negative, multiplex PCR for Streptococcus pneumoniae was positive even 10 h after beginning of effective antibiotic therapy. Subsequent echocardiogram revealed mitral valve endocarditis and the patient underwent valve replacement.

Conclusion
Altogether, bacterial meningitis presents with cardinal clinical signs only half of cases. Lumbar puncture remains crucial, and our patient’s CSF findings aligned with bacterial meningitis. Multiplex PCR aided in diagnosis, even after antibiotic treatment. The case highlights the importance of prompt lumbar puncture despite antibiotic pre-treatment. The patient’s Austrian syndrome, characterized by meningitis, endocarditis, and pneumonia, emphasizes the need for vigilance regarding skin lesions, early cerebral infarctions, and iritis. This case emphasizes the complexity of bacterial meningitis diagnosis and the utility of multiplex PCR, especially in prolonged antibiotic-treated patients. However, PCR cannot replace cultures when it comes to adapting therapy based on the antibiotic sensitivity of the causative pathogen. Awareness of Austrian syndrome’s diverse manifestations is crucial for timely recognition and appropriate management.
Time to first antenatal care visit and its predictors among women in Kenya: Weibull gamma shared frailty model (based on the recent 2022 KDHS data)
Authors: Kase Bizunesh Fantahun , Seifu Beminate Lemma , Mare Kusse Urmale , Shibeshi Abdu Hailu , Asebe Hiwot Altaye , Gemeda Kebede , Asmare Zufan Alamrie , Asgedom Yordanos Sisay , Fente Bezawit Melak , Lombebo Afework Alemu , Tebeje Tsion Mulat 
Published: January 2025

Abstract

Background
The first trimester of pregnancy is critical for fetal development, making early antenatal care visits essential for timely check-ups and managing potential complications. However, delayed antenatal care initiation remains a public health challenge in sub-Saharan Africa, including Kenya. Therefore, this study aimed to assess and provide up-to-date information on time to first antenatal care visit and its predictors among women in Kenya, using data from the most recent 2022 Kenya Demographic and Health Survey (KDHS).

Methods
This community-based cross-sectional study analyzed data from 19,530 birth histories in the 2022 Kenya Demographic and Health Survey (KDHS). The primary outcome was the timing of the first antenatal care (ANC) visit, classified as timely if it occurred in the first trimester. Shared frailty survival models were used to account for the hierarchical data structure and unobserved heterogeneity, with the Weibull gamma model identified as the best fit based on Information Criteria (AIC), and Bayesian Information Criteria (BIC). Variables with p < 0.2 entered multivariable analysis, and results were reported as Adjusted Hazard Ratios (AHR) with 95% Confidence Intervals (CI) using the Weibull gamma model.

Results
The study found that the median time for the first antenatal care (ANC) visit in Kenya was four months. Significant predictors of ANC timing included women’s age (35–49 years: AHR 0.83; 95% CI: 0.72–0.95), education level (higher: AHR 1.45; 95% CI: 1.17–1.78), media exposure (yes: AHR 1.21; 95% CI: 1.05–1.39), parity (four or more children: AHR 0.81; 95% CI: 0.72–0.91), wealth status (richest: AHR 2.00; 95% CI: 1.63–2.43), desire for more children (did not want more: AHR 0.64; 95% CI: 0.54–0.77), residence (rural: AHR 1.22; 95% CI: 1.07–1.39), and religion (Islam: AHR 0.76; 95% CI: 0.64–0.89).

Conclusion
The median time for the first ANC visit exceeds the World Health Organization’s recommendation of initiating care within the first trimester. These findings underscore the need for targeted interventions to promote timely ANC, especially among women with limited media exposure, high parity, lower socioeconomic status, and specific religious followers.
Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies
Authors: Assempoor Ramin , Daneshvar Mohammad Shahabaddin , Taghvaei Aryan , Abroy Alireza Sattari , Azimi Amir , Nelson John R. , Hosseini Kaveh 
Published: January 2025

Abstract

Background
Atherogenic index of plasma (AIP), a novel logarithmic index that combines fasting triglyceride and high-density lipoprotein cholesterol concentrations, is associated with the burden of atherosclerosis. This study aimed to evaluate the relationship between AIP and coronary artery disease (CAD) risk, severity, and prognosis in populations with and without established CAD.

Methods
PubMed, Embase, and Web of Science were systematically searched from the inception of each database to August 13, 2024. Cross-sectional studies, case-control studies, and prospective or retrospective cohort studies using multivariate analysis were included. Given that the true effect size may differ across studies, a random-effects model for all analyses was applied.

Results
Fifty-one observational studies were included in this study. Patients with higher AIP were more likely to have CAD (odds ratio (OR): 2.79, 95% CI 1.75–4.45, P < 0.00001). Furthermore, these patients were more likely to have coronary artery calcification (OR: 2.28, 95% CI 1.74–3.00, P < 0.00001), multivessel CAD (OR: 2.04, 95% CI 1.50–2.77, P < 0.00001), and an increased risk of plaque progression (OR: 1.49, 95% CI 1.17–1.91, P = 0.001). In populations without established CAD, higher AIP levels were associated with an increased risk of Major adverse cardiovascular events (MACE) (hazard ratio (HR): 1.28, 95% CI 1.22–1.35, P < 0.00001). Interestingly, this finding was consistent in patients presenting with acute coronary syndrome (HR: 1.59, 95% CI 1.33–1.89, P < 0.00001) and patients with chronic coronary syndrome or stable CAD (HR: 1.65, 95% CI 1.15–2.37, P = 0.007).

Conclusions
This meta-analysis demonstrates that elevated AIP is strongly associated with increased CAD risk, greater severity, and poorer prognosis in populations with and without established CAD. However, more studies are needed to evaluate the predictive performance and determine the optimal cut-off for AIP in different populations.

Graphical abstract
The effects of training female students in emotion regulation techniques on their social problem-solving skills and social anxiety: a randomized controlled trial
Authors: Akbari Ashraf , Torabizadeh Camellia , Nick Narjes , Setoodeh Giti , Ghaemmaghami Parvin 
Published: January 2025

Abstract

Background
Social anxiety is one of the most prevalent anxiety-related disorders among adolescents with many adverse effects on the social and academic lives of this population. In addition, poor social problem-solving skills can aggravate anxiety in individuals suffering from anxiety. Emotion regulation can help adolescents control and moderate their feelings, thereby enabling them to understand their emotions better, cope with their negative emotions in a positive way, and adopt a more realistic approach to solving their problems. The objective of the present study is to investigate the effects of educating female students in emotion regulation techniques on their social problem-solving skills and social anxiety.

Method
This study was a randomized controlled trial conducted in Iran, utilizing a pretest-posttest design with control and intervention groups. The subjects were 47 female high-school second graders who were randomly divided into a control (25 students) and an intervention group (22 students). The intervention group was collectively educated in emotion regulation techniques in weekly one-hour sessions for eight weeks. The control group did not receive any intervention. The social anxiety and social problem-solving scales were completed by both groups before, immediately after, and one month after the intervention. The collected data were analyzed in SPSS v. 22 and level of significance was set at p < 0.05.

Result
Data analysis of the intervention group compared to the control group demonstrated that group training in emotional regulation techniques effectively increased social problem-solving skills scores (p = 0.003) and decreased social anxiety scores (p < 0.0001) among students in the intervention group compared to their pretest scores. These effects remained stable during the follow-up phase.

Conclusion
In view of the prevalence of social anxiety among adolescents, it is suggested that the policymakers and administrators in the education system promote emotion regulation skills in adolescent students to facilitate their psychological adaptation and improve their emotional capabilities.

Trial registration
The present study was registered under the code IRCT20220413054521N1 (Registration date: 27/02/2024) in the Iranian Registry of Clinical Trials.
De novo biosynthesis of quercetin in Yarrowia Lipolytica through systematic metabolic engineering for enhanced yield
Authors: Dong Yuxing , Wei Wenping , Li Mengfan , Qian Tao , Xu Jiayun , Chu Xiaohe , Ye Bang-Ce 
Published: January 2025

Abstract
Kaempferol and quercetin possess various biological activities, making them valuable in food and medicine. However, their production via traditional methods is often inefficient. This study aims to address this gap by engineering the yeast Yarrowia lipolytica to achieve high yields of these flavonoids. We designed a kaempferol biosynthetic pathway by integrating multiple-copy fusion enzyme expression modules, F3H-(GGGGS)2-FLS, into the genome with an optimized linker (GGGGS)2 to enhance kaempferol production from naringenin. To synthesize quercetin de novo, we introduced the FMOCPR gene into the kaempferol-synthesizing strain using the optimized pFBAin promoter. Notably, increasing glucose concentration effectively boosted the production of both flavonoids. Our results demonstrated kaempferol and quercetin titers reaching 194.30 ± 7.69 and 278.92 ± 11.58 mg/L, respectively, in shake-flask cultures. These findings suggest that Y. lipolytica is a promising platform for the efficient production of flavonoid-derived products.
Bullying in the healthcare workplace: a cross-sectional study among Nigerian physiotherapists
Authors: Onwuakagba Ifeoma Uchenna , Uchendu Ebubechukwu Ogochukwu , Obiekwe Sochima Johnmark , Kanu Favour Chidera , Amaechi Ifeoma Adaigwe , Okafor Anita Chinwendu , Akosile Christopher Olusanjo , Okoye Emmanuel Chiebuka 
Published: January 2025

Abstract

Background
Workplace bullying (WPB) can impact the overall well-being of healthcare professionals as well as the care provided to patients. There are no available studies on the prevalence of WPB among physiotherapists, especially in Nigeria.

Objective
This study aimed to investigate the prevalence of WPB and its associated factors among clinical physiotherapists in Nigeria.

Method
This cross-sectional study was conducted among 372 Nigerian clinical physiotherapists conveniently recruited at various hospitals. Data was obtained using an adapted self-administered questionnaire and the Negative Acts Questionnaire-Revised (NAQ-R).

Results
The prevalence of bullying was 42.1%, with participants reporting repeated experiences within the previous 6 months. A high proportion of participants (83.1%) witnessed someone else being bullied at their workplace. The majority of the bullying incidents involved superiors targeting subordinates (83.7%). Participants reported that the most prevalent forms of bullying were verbal aggression (64.4%), followed by intimidating acts (59.4%), insulting remarks, gossip (58.3%), mind games (29.8%), and neglect of opinions (37.6%). No significant associations were found with gender (p = 0.632), religion (p = 0.151), marital status (p = 0.085), ethnicity (p = 0.896), educational attainment (p = 0.150), or rank (p = 0.091). However, significant associations were identified between WPB and years of practice (p = 0.041), and organization of employment (p < 0.001).

Conclusion
The observed prevalence of WPB among Nigerian clinical physiotherapists is of great concern. Targeted interventions and policy developments are highly recommended to create a safer work environment.
God and Revolution in Iran
Authors: Doostdar Alireza 
Published: January 2025

Abstract
This article examines the power of God in postrevolutionary Iran through an exploration of divine ambiguity in relation to political experience. Over the past four decades, the Iranian political-theological landscape has gone through dramatic transformations in imagining God's interventions in the space of human history. For Ayatollah Khomeini and his revolutionary followers, the Islamic Republic began as a miracle and matured with divine assistance for the duration of the war with Iraq. In 2022, God returned as an uncertain ally for revolutionaries in the Woman, Life, Freedom uprising. In the intervening years, anxieties about divine punishment have jostled with heretical, humor-filled rage at God's injustice for the suffering of the Iranian people. This article explores these moments as windows onto political hope and despair, where the present, past, and future are imagined through a relationship, by turns devout and irreverent, with Islam's supreme being.
Dispossessing Property
Authors: Eldridge Aaron Frederick 
Published: January 2025

Abstract
This article examines ethnographically the efforts of a group of women to form a new Orthodox monastic collective amid the collapse of Lebanon's sectarian neoliberal economy and the perpetual threat of war with a particular focus on the way property as a concept necessarily misrecognizes their struggle. The article engages with the specific history of the waqf, known today as a “religious” endowment, in the Levant and its novel configuration in the conjuncture of primitive accumulation. It argues that making waqf lands into property occasions a spontaneous idealization of these relations as sectarianism, the belated juridical force of which instigates a temporal and spatial cleavage, an interior exteriority, marked by a temporal “prior” that is also a spatial margin (the “domestic” space of women and religion). The mode of monastic action, dispossession, teaches that the accumulation of capital, sectarianization, is not the auto-generation that property conceptually proffers. In the falling away of property's effect as an “always already,” monastic struggle marks an activity of collective reorientation occasioned by dispossession.
Waste of Time is Worse Than Death
Authors: Berg Hanna 
Published: January 2025

Abstract
This article examines how experiences of time and waiting are shaped by theological imaginations among Syrian Sunni Muslims living as asylum seekers in Jordan. While anthropological studies on time and waiting in contexts of displacement most often place human agency at the center of analysis, attending to people's understandings of waste of time (daya‘ al-waqt) in relation to divine power allows for moving beyond secular, materialistic understandings of time. Placing God at the center of analysis, the article explores how temporal inequalities created in and through the humanitarian protracted context in Jordan are conceptualized along notions of life and death, and it explores the role of God in such conceptualizations. This article takes an ethnographic approach to address the relationship between human sa‘y (strive) and divine granting of faraj (ease) to explore how God's agency materializes into something tangible when addressed through human mobilization. Suggesting that sa‘y is not only a virtue on its own, but a fundamental part of sabr, the article adds to theological understandings of the virtue of endurance as opposed to emotional surge and unrest, and it provides an analytical space to rethink waiting in contexts of displacement beyond bare “migranthood.”
Introduction
Authors: Goodgame Clayton 
Published: January 2025

Abstract
This introduction outlines the special section's intervention in the study of religion, property, and political economy, suggesting that the emerging literature on Middle Eastern Christianities can provide a clearer view of how economic relations are influenced by religious ones and vice versa. Engaging with scholarship on property relations on the one hand (within and beyond the Middle East) and Christianity on the other, the introduction proposes an approach to church property that holds the economic and religious aspects of property in productive tension. It attempts this both empirically, employing sources that elicit religious experience as well as larger social forces, and theoretically, challenging canned distinctions between sacred space and profane property in favor of a view that includes human and nonhuman relations.