bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hollow mesoporous organosilica nanoparticles reduced graphene oxide based nanosystem for multimodal image‐guided photothermal/photodynamic/chemo combinational therapy triggered by near‐infrared
Authors: Zhang Chenguang , Cai Yuting , Pengrui Dang , Wang Jiechen , Wang Lu , Xu Jiayun , Wu Yuhan , Liu Wenwen , Chen Lili , Luo Zhengtang , Deng Feilong 
Published: March 2023

AbstractDeveloping a nanosystem that can perform multimodal imaging‐guided combination therapy is highly desirable but challenging. In this study, we introduced multifunctional nanoparticles (NPs) consisting of graphene oxide‐grafted hollow mesoporous organosilica loaded with the drug doxorubicin (DOX) and photosensitizers tetraphenylporphyrin (TPP). These NPs were encapsulated by thermosensitive liposomes that release their contents once the temperature exceeds a certain threshold. Metal oxide NPs grown on the graphene oxide (GO) surface served multiple roles, including enhancing photothermal efficiency, acting as contrast agents to improve magnetic resonance imaging, increasing the sensitivity and specificity of photoacoustic imaging, and catalysing hydrogen peroxide for the generation of reactive oxygen species (ROS). When locally injected, the HMONs‐rNGO@Fe3O4/MnOx@FA/DOX/TPP NPs effectively enriched in subcutaneous Hela cell tumour of mice. The photothermal/photodynamic/chemo combination therapy triggered by near‐infrared (NIR) successfully suppressed the tumour without noticeable side effects. This study presented a unique approach to develop multimodal imaging‐guided combination therapy for cancer.
Tumour‐derived exosomes in liver metastasis: A Pandora's box
Authors: Li Sini , Qu Yan , Liu Lihui , Wang Chao , Yuan Li , Bai Hua , Wang Jie 
Published: March 2023

AbstractThe liver is a common secondary metastasis site of many malignant tumours, such as the colorectum, pancreas, stomach, breast, prostate, and lung cancer. The clinical management of liver metastases is challenging because of their strong heterogeneity, rapid progression, and poor prognosis. Now, exosomes, small membrane vesicles that are 40–160 nm in size, are released by tumour cells, namely, tumour‐derived exosomes (TDEs), and are being increasingly studied because they can retain the original characteristics of tumour cells. Cell–cell communication via TDEs is pivotal for liver pre‐metastatic niche (PMN) formation and liver metastasis; thus, TDEs can provide a theoretical basis to intensively study the potential mechanisms of liver metastasis and new insights into the diagnosis and treatment of liver metastasis. Here, we systematically review current research progress about the roles and possible regulatory mechanisms of TDE cargos in liver metastasis, focusing on the functions of TDEs in liver PMN formation. In addition, we discuss the clinical utility of TDEs in liver metastasis, including TDEs as potential biomarkers, and therapeutic approaches for future research reference in this field.
Superior caval vein partially overriding the interatrial septum–A fetal echocardiographic sign of superior sinus venosus defect. Reporting its rare association with coarctation of aorta in a fetus and its outcome
Authors: Karmegaraj Balaganesh 
Published: March 2023

AbstractPrenatal diagnosis of superior sinus venosus defect has never been reported in the literature. I describe here an echocardiographic sign which is helpful in diagnosing this defect in a 35 + 2 weeks fetus and its rare association with coarctation of aorta.
Dose‐adjusted EPOCH and rituximab (DA‐EPOCH‐R) in older patients with high‐risk aggressive diffuse large B‐cell lymphoma: A real‐life multicenter study by the Croatian Cooperative Group for Hematologic diseases (KroHem)
Authors: Mitrovic Zdravko , Dujmovic Dino , Jaksic Ozren , Kinda Sandra Basic , Gacina Petar , Perisa Vlatka , Prka Zeljko , Dreta Barbara , Galusic Davor , Holik Hrvoje , Pejsa Vlatko , Aurer Igor 
Published: March 2023

AbstractPurposeDose‐adjusted EPOCH and rituximab (DA‐EPOCH‐R) is a regimen used for the treatment of high‐risk diffuse large B‐cell lymphoma (DLBCL) designed to overcome resistance to standard R‐CHOP by combining prolonged exposure of lymphoma cells to cytotoxic agents and dose‐adjustment based on toxicity. Data on outcomes of older patients are scarce.Patients and MethodsWe collected data on patients with newly diagnosed high‐risk DLBCL older than 60 years treated with DA‐EPOCH‐R. High‐risk patients were defined by the age‐adjusted international prognostic index score 2 or 3.ResultsA total of 120 patients were included. Median age was 69 years (range 60–82). Response rate was 74%; with 59% complete responses. Dose of DA‐EPOCH‐R was escalated in 50 patients (42%). Three‐year progression‐free survival (PFS) and overall survival (OS) was 53% and 58%, respectively, with treatment‐related mortality (TRM) of 13%. In univariate analysis, favorable prognostic factors were performance status (PS) (0–2 vs. 3–4), age (<70 vs. ≥70 years), and center. In multivariate analysis, PS and center retained prognostic significance. Patients with PS 0–2 had 3‐year PFS and OS of 58% and 64%, respectively, with TRM of 6%.ConclusionDA‐EPOCH‐R is efficacious in sufficiently fit older high‐risk DLBCL patients. Patients with poor PS have unacceptable toxicity and require less intensive therapy.
Integration–segregation dynamics in functional networks of individuals diagnosed with schizophrenia
Authors: Iglesias‐Parro Sergio , Ruiz de Miras Juan , Soriano Maria Felipa , Ibáñez‐Molina Antonio J. 
Published: March 2023

AbstractSchizophrenia has been associated with dysfunction in information integration/segregation dynamics. One of the neural networks whose role has been most investigated in schizophrenia is the default mode network (DMN). In this study, we have explored the possible alteration of integration and segregation dynamics in individuals diagnosed with schizophrenia with respect to healthy controls, based on the study of the topological properties of the graphs derived from the functional connectivity between the nodes of the DMN in the resting state. Our results indicate that the patients show a diminution of the modularity of the DMN and a higher global efficiency, in sparse graphs. Our data emphasise the interest in studying temporal changes in network measures and are compatible with the hypothesis of randomization of functional networks in schizophrenia.
Both perimenstrual and nonperimenstrual migraine days respond to anti‐calcitonin gene‐related peptide (receptor) antibodies
Authors: Verhagen Iris E. , de Vries Lentsch Simone , van der Arend Britt W. H. , le Cessie Saskia , MaassenVanDenBrink Antoinette , Terwindt Gisela M. 
Published: March 2023

AbstractBackground and purposeAnti‐calcitonin gene‐related peptide (CGRP) (receptor) antibodies effectively reduce overall migraine attack frequency, but whether there are differences in effect between perimenstrual and nonperimenstrual migraine days has not been investigated.MethodsWe performed a single‐arm study among women with migraine. Participants were followed with electronic E‐diaries during one (pretreatment) baseline month and 6 months of treatment with either erenumab or fremanezumab. Differences in treatment effect on perimenstrual and nonperimenstrual migraine days were assessed using a mixed effects logistic regression model, with migraine day as dependent variable; treatment, menstrual window, and an interaction term (treatment × menstrual window) as fixed effects; and patient as a random effect.ResultsThere was no interaction between the menstrual window and treatment effect, indicating that the reduction in migraine days under treatment was similar during the menstrual window and the remainder of the menstrual cycle (odds ratio for treatment = 0.44, 95% confidence interval = 0.38–0.51).ConclusionsOur findings support prophylactic use of anti‐CGRP (receptor) antibodies for women with menstrual migraine, as this leads to consistent reductions in number of migraine days during the entire menstrual cycle.
Evaluation of outcomes with permanent vascular access in an elderly Korean population based on the National Health Insurance Service database
Authors: Kim Hyangkyoung , Park Hoon Suk , Ban Tae Hyun , Yang Seung Boo , Kwon Young joo ,   the vascular access working group of the Korean Society of Dialysis Access
Published: March 2023

AbstractIntroductionAs nearly half of patients with end‐stage kidney disease (ESKD) who initiate hemodialysis (HD) are over 65 years old (commonly defined as elderly), the fistula first strategy is controversial even in HD patients ≥65 years.MethodsIn Korea's National Health Insurance Service database from 2008 to 2019, 41,989 elderly (≥ 65 years) HD patients were retrospectively reviewed to identify their clinical characteristics and outcomes. Vascular access (VA) patencies, risk factors associated with patencies and patient survival between arteriovenous fistula (AVF) and arteriovenous graft (AVG) were compared.ResultsElderly AVF group (n = 28,467) had superior primary, primary assisted, and secondary patencies than elderly AVG group (n = 13,522) (all p values are <0.001). Patient survival was also better in the elderly AVF group than in the elderly AVG (p < 0.001). In multivariate Cox regression analyses for diverse outcomes, AVG (vs. AVF) was identified as a risk factor for all‐cause mortality (adjusted hazard ratio [HR]: 1.307; 95% confidence interval [CI]: 1.272–1.343; p < 0.001), primary patency (adjusted HR: 1.745; 95% CI: 1.701–1.790; p < 0.001), primary‐assisted patency (adjusted HR: 2.163; 95% CI: 2.095–2.233; p < 0.001), and secondary patency (adjusted HR: 3.718; 95% CI: 3.533–3.913; p < 0.001).ConclusionOur study demonstrated that as a permanent VA for HD, AVF should be strongly considered in elderly (≥ 65 years) ESKD Korean patients. The age limit for AVF creation in ESKD patients should be adjusted more upward.
Functional magnetic resonance imaging of headache: Issues, best‐practices, and new directions, a narrative review
Authors: Hranilovich Jennifer A. , Legget Kristina T. , Dodd Keith C. , Wylie Korey P. , Tregellas Jason R. 
Published: March 2023

AbstractObjectiveTo ensure readers are informed consumers of functional magnetic resonance imaging (fMRI) research in headache, to outline ongoing challenges in this area of research, and to describe potential considerations when asked to collaborate on fMRI research in headache, as well as to suggest future directions for improvement in the field.BackgroundFunctional MRI has played a key role in understanding headache pathophysiology, and mapping networks involved with headache‐related brain activity have the potential to identify intervention targets. Some investigators have also begun to explore its use for diagnosis.Methods/ResultsThe manuscript is a narrative review of the current best practices in fMRI in headache research, including guidelines on transparency and reproducibility. It also contains an outline of the fundamentals of MRI theory, task‐related study design, resting‐state functional connectivity, relevant statistics and power analysis, image preprocessing, and other considerations essential to the field.ConclusionBest practices to increase reproducibility include methods transparency, eliminating error, using a priori hypotheses and power calculations, using standardized instruments and diagnostic criteria, and developing large‐scale, publicly available datasets.
Undergraduates' orientations towards student–university relationships: Measurement and associations with student characteristics and engagement
Authors: Maloshonok Natalia , Shcheglova Irina , Zhuchkova Svetlana 
Published: March 2023

AbstractThis study explored students' orientations towards student–university relationships and how they differ with regard to student characteristics and engagement. We developed an instrument measuring student orientations and utilised it in a survey of Russian undergraduates. Using latent class analysis, we identified the following types of Russian students' orientations: instructivists, consumerists, constructivists, and students with mixed orientations. As the results showed, the majority of our respondents have consumerist or mixed orientations that mostly mismatch with the actual models of student–university relationships at Russian universities. We also found that students with these orientations are less engaged than instructivists and constructivists. These findings demonstrate the importance of seeking an optimal match between diverse undergraduate orientations and the actual educational model, which fits national and institutional contexts.
Pasting and retrogradation properties of rice starch with phenolics from three varieties of brown rice
Authors: Li Huan‐Huan , Li Ren , Wu Fei‐Fei , Zhai Xiao‐Tong , Qiao Cong‐Cong , Xiao Zhi‐Gang , Wu Na‐Na , Tan Bin 
Published: March 2023

SummaryThis work evaluated the influence of phenolics from Black, Indica and Japonica rice bran (2.5–10%) on pasting and retrogradation properties of rice starch. The breakdown, setback, enthalpy values and retrogradation percentage of rice starch were decreased, and the pasting temperature was enhanced with the phenolics from three varieties of brown rice. X‐ray diffraction results suggested that new V‐type crystal at 13.1° was formed and relative crystallinity of rice starch was decreased. The results from fourier transform infrared spectroscopy exhibited that the 1047/1022 cm−1 values of rice starch were decreased with the content increase of phenolics from three varieties of brown rice. The phenolics from three varieties of brown rice resulted in loose surface structure of rice starch. This work may provide evidences for utilisation of phenolics from different varieties of brown rice to improve quality of rice products and inhibit retrogradation of rice starch.
Radical prostatectomy trends between 2010 and 2020 in Ehime, Japan, identified using data from the Medical Investigation Cancer Network (MICAN) study
Authors: Hashine Katsuyoshi , Yamashita Natsumi , Tachou Takatoshi , Kan Masaharu , Yanagaki Takahiro , Oka Akihiro , Takeda Hajime , Shirato Akitomi , Watanabe Uichi , Miura Noriyoshi , Saika Takashi 
Published: March 2023

ObjectivesThe use of radical prostatectomy is increasing with the rising incidence of prostate cancer. We assessed the surgical trends related to radical prostatectomy using data from a multi‐center, retrospective cohort study, the MICAN (Medical Investigation Cancer Network) study, which was conducted in all the urology‐related medical facilities in Ehime Prefecture, Japan.MethodsWe compared data from the MICAN study with prostate biopsy registry data collected in Ehime between 2010 and 2020 and recorded the surgical trends.ResultsThere was a significant increase in the mean age of patients with positive biopsies, and the positivity rate increased from 46.3% in 2010 to 60.5% in 2020, while the number of biopsies obtained decreased. The number of radical prostatectomies performed increased over the years, with robot‐assisted radical prostatectomy becoming the predominant procedure. In 2020, robot‐assisted radical prostatectomies accounted for 96.0% of the surgeries performed. The age at surgery also gradually increased. Of the registered patients aged ≤75 years, 40.5% underwent surgery in 2010, compared with 83.1% in 2020. The prevalence of surgery also increased from 4.6% to 29.8% in patients aged >75 years. There was a gradual increase in the proportion of high‐risk cases, from 29.3% to 44.0%, but a decrease in that of low‐risk cases, from 23.8% in 2010 to 11.4% in 2020.ConclusionsWe have shown that the number of radical prostatectomies performed in Ehime is increasing in patients aged both ≤75 and >75 years. The proportion of low‐risk cases has decreased, while that of high‐risk cases has increased.
Trends in the age of hospitalized patients with urological cancers: A 17‐year experience
Authors: Ishii Noritaka , Hatakeyama Shingo , Miura Hikari , Tanaka Ryuma , Oishi Takuya , Horiguchi Hirotaka , Hosogoe Shogo , Fujita Naoki , Iwamura Hiromichi , Okamoto Teppei , Yamamoto Hayato , Yoneyama Takahiro , Hashimoto Yasuhiro , Ohyama Chikara 
Published: March 2023

ObjectivesTo investigate the impact of global aging on the trends in the age of hospitalized patients with a urological cancer diagnosis.MethodsWe retrospectively evaluated a cumulative total of 10 652 cases of referred patients (n = 6637) with a urological disease who were hospitalized in our institution between January 2005 and December 2021. We compared age and the proportion of patients aged ≥80 years among patients who were hospitalized in the urological ward between the period of 2005–2013 and that of 2014–2021.ResultsWe identified 8168 hospitalized patients with urological cancer. The median age was significantly increased in patients with urological cancer between the periods of 2005–2013 and 2014–2021. The proportion of hospitalized patients with urological cancer aged ≥80 years was significantly increased between the periods of 2005–2013 (9.3%) and 2014–2021 (13.8%). The median ages of the patients with urothelial cancer (UC) and renal cell carcinoma (RCC), but not the median age of those with prostate cancer (PC), were significantly increased between the study periods. The proportion of hospitalized patients with UC, but not the proportions of those with PC and RCC, aged ≥80 years was significantly increased between the study periods.ConclusionsThe age of patients with urological cancer who were hospitalized in the urological ward and the proportion of patients with UC aged ≥80 years significantly increased over the entire study period.
Comment on ‘Speaking up during the COVID‐19 pandemic: Nurses' experiences of organizational disregard and silence’
Authors: Magon Arianna , Caruso Rosario 
Published: March 2023

AbstractAimWe aimed to highlight some salient thoughts regarding the importance of addressing the challenges nurses face when speaking up, particularly in situations involving power, hierarchy, fear and threat, and boost scientific and professional debates around this timely topic, starting from the qualitative article published by Abrams et al. (Journal of Advanced Nursing; 2023).BackgroundAlthough acknowledging the contribution of nurses to patient care and their ability to detect and manage potential safety hazards through observations and insights, nurses may encounter challenges in expressing their concerns, particularly in situations that involve power dynamics and hierarchical structures. In this regard, Abrams et al. (Journal of Advanced Nursing; 2023) studied nurse challenges in speaking up during COVID‐19, identifying key elements related to speaking up, consequences and responses. Discussing this topic may aid scientific and professional debate.DesignCommentary on a qualitative design performed with a social constructionist approach to critically evaluate how nurses spoke up during the COVID‐19 pandemic and the resulting outcomes.MethodSearching for relevant literature to support acknowledging and addressing obstacles nurses face when expressing concerns by speaking up and promoting scholarly and professional discussions on this topic.FindingsThe challenges faced by nurses when speaking up during the COVID‐19 pandemic might reflect broader social, cultural and academic trends: power dynamics, hierarchical structures, deference to authority in healthcare organizations and a lack of attention to nurses' experiences in the literature can make it difficult for nurses to raise their concerns.ConclusionCreating a supportive environment that values nurses' perspectives can help healthcare organizations tap into their knowledge and make data‐driven decisions leading to better patient outcomes, job satisfaction and organizational performance. Effective policies, best practices and research are necessary to understand nurses' experiences in speaking up and designing strategies to create healthy work environments.
Punishment, Public Safety, and Collateral Legal Consequences
Authors: Lippke Richard L. 
Published: March 2023

ABSTRACTWhat are termed the ‘collateral legal consequences’ (or CLCs) of criminal conviction have been defended in a variety of ways. The focus in this article is on efforts to justify the burdens and restrictions they involve as nonpenal measures designed to secure public safety. Zachary Hoskins' careful defense of such public‐safety CLCs is utilized as a point of departure. Although it is granted that such measures might be defensible, the many complications and problems of ensuring that they do not amount to further legal punishment and are kept within reasonable bounds are explored. I argue that the state is unlikely to deploy such public safety measures wisely and with sufficient restraint.
Phoxinus abanticus, a new species from the Lake Abant drainage in Türkiye (Teleostei: Leuciscidae)
Authors: Turan Davut , Bayçelebi Esra , Özuluğ Müfit , Gaygusuz Özcan , Aksu İsmail 
Published: March 2023

AbstractPhoxinus abanticus, a new species, is described from the Lake Abant basin. It is distinguished from Phoxinus species in Türkiye and adjacent waters by the presence of fewer lateral line scales (60–69, vs. 75–91 in Phoxinus colchicus, 75–90 in Phoxinus strandjae); a deeper caudal peduncle (caudal peduncle depth: 1.8–2.3 times in length, vs. 2.4–2.9 in P. colchicus; 2.5–3.2 in P. strandjae); the absence of scales in the breast of males (vs. present); and ventral body reddish in nuptial colouration pattern for male (vs. brackish). The new species, P. abanticus, is also distinguished from its closest relative, P. strandjae, by a minimum of 3.40% genetic distance in the mtDNA cytochrome b (cyt b) gene.
A ray of hope? The re‐appearance of Irish Sea skate decades after local extinction
Authors: Moore Alec B.M. 
Published: March 2023

AbstractA 2019 photograph of a blue skate Dipturus batis caught in Welsh waters is the first species‐specific evidence of the “common skate” complex occurring in its former range in the main body of the Irish Sea over four decades after it was considered to have been extirpated there. This possible precursor to recolonisation of former range adds to growing evidence for the recovery of skate species in the North Atlantic and highlights the valuable role of anglers and social media as a complement to important, yet costly, scientific surveys when monitoring rare fishes.
The efficacy of preharvest application of electrolyzed water and chemical sanitizers against foodborne pathogen surrogates on leafy green vegetables
Authors: Shang Hongshan , Huang Linxi , Stanley Roger , Deaker Rosalind , Bowman John P. 
Published: March 2023

AbstractPreharvest control strategies, to reduce or eliminate pathogenic bacteria in leafy vegetables that may be consumed raw, may provide additional food safety protection and shelf life quality extension beyond what is possible to achieve with postharvest sanitation alone. The aim of this study was to characterize the efficacy and effect of contact time of electrolyzed water (e‐water), 1‐bromo‐3‐chloro‐5‐dimethylhydantoin (BCDMH), and peracetic acid (PAA) at 80 and 150 ppm against pathogen surrogates Escherichia coli M23 (E. coli M23)and Listeria innocua ATCC 33090 (L. innocua), and a representative spoilage microorganism Pseudomonas fluorescens (P. fluorescens) on leafy green vegetables (LGV) mizuna, rocket (arugula), and red chard. Each of the leafy vegetables has a distinctly different leaf architectures that could alter the effectiveness of preharvest sanitation treatments. e‐Water, BCDMH and PAA were equally effective in inactivating plant total viable count, E. coli M23, L. innocua and P. fluorescens (reduction compared to water control—0.5–4.0 log CFU/g). On average an additional 0.8 (0.4–1.1) log CFU/g inactivation was obtained by increasing sanitizer contact time from 30 min to 2 h, whereas increasing sanitizer concentrations produced, at maximum, an extra 0.5 log CFU/g inactivation. These findings suggest that e‐water, BCDMH, and PAA are all useful for in‐field preharvest application on a wide range of plants and increasing contact time rather than concentration improves sanitation efficacy.