bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAKNA BERAGAMA MENURUT IMMANUEL KANT DALAM RELIGION WITHIN THE LIMITS OF REASONALONE
Authors: Iqbal Imam 
Published: April 2023

The searching oflmmanuel Kant's thought in this paper will try to explain his ideas concerning to the meaning of religion from his critical philosophical perspective by set up from his work Religion within the Limits of Reason Alone. That work, will show later, is one of important Kant's work, especially concerning the relation between reason, religion, and morality. Although Religion could be classified as a work in philosophy of religion's field, however Kant's writing style in this work was not in popular fashion as commonly the work in philosophy of religion's field to be written. Kant's views ofreligion and the meaning ofbeing religious in this work are closely related to the moral frame work that he explained in his other works. The writer underlines some important points of Kant's thoughts: First, Religion has showed Kant's interest to religious problems, especially concerning religious meaning, in relation to morality and rationality. Second, the main discussion in Religion is about religious meaning. Third, Kant's explanation to religious meaning in Religion could be traced in to areas, i.e. individual area and social-community area. Fourth, the core of religious meaning in Religion is situated to Kant's implicit invitation to shift from just as ''having religion" to the ''being religious", or from having religious falsely to being religious authentically. Fifth, being religious or to be religious authentically is a representation of critical religious attitude.
Beragama Di Tengah Badai Kemanusiaan
Authors: Mutiullah Mutiullah 
Published: April 2023

Religion is one requirement of human life. Since beginning of life, human needs religion as guide to appoint the good conditions. It has many contributions to civilizations such as hopefully to save. Also, it gives solving to many human’s problems. Recently, religion has challenging that is to solve many social conflicts as poverty and fundamentalism thoughts. So, what should religion does? There are two answers. The first, religion has to reinterpret his dogma. The second is religion as future ideology must to solve many human problems.
MEMBACA KISAH NABI DAUD MENGGUNAKAN SEMIOTIKA ROLAND BARTHES
Authors: Santoso Jarot Nanang , Abror Indal 
Published: April 2023

Roland Barthes’s semiotics, as a science that is concerned in coding, was applied in analyzing the story of the Prophet David. Application of multilevel readings; Heuristic readings and retroactive readings in the story of the Prophet David consisting of 25 lexia texts of the Koran, were found to be of significance identified from certain codes, including: a) hermeunetic code / puzzle code, b) symbolic code “David” symbol from the ideal leader, c) the semic code or the “ark” connotative code means the importance of preserving and preserving relics, d) the proaretic code / action code “David fell” means humility acknowledging mistakes not looking at someone’s status, e) gnomic code or code Cultural “Goliath and its troops” means that there will always be those who spread damage, and during this time God’s intervention will also contribute to protecting the universe through the other party who spread goodness, and so on.
KONSEP MAHABBAH JALALUDDIN RUMI
Authors: Octafany Assya 
Published: April 2023

This article explores Rumi's mahabbah concept. Currently, in society, the concept of love is degrading in meaning, resulting in its constriction. This is because the concept of mahabbah, which we usually refer to as "love," is unfamiliar to the general population. In general, society equates love with liking the other sex. Spite of the fact , Rumi asserts that love is not confined to that. The notion of love will be addressed in this study via the lens of Jalaluddin Rumi, specifically the nature of love and its application in life. The findings of this study provide an outline of the type of love that people should possess: love powerful enough to cause someone to love their god.
KEUNGGULAN METODE DEMONSTRATIF TERHADAP METODE RETORIKA DAN DIALEKTIKA: MENGUAK METODE KRITIK FILSAFAT IBN RUSYD
Authors: Bistara Raha 
Published: April 2023

This article shows how the demonstrative method (burhani) is more superior to rhetoric (khatabbi) and dialectic method (jaddali), the use of the demonstrative method is based on the utilization of the mind. Ibn Rusyd stated that the demonstrative method is considered the right method for seeking the answers above the questions on the subject of religion and philosophy. However, it is not amazed Ibn Rusyd used a demonstrative method to criticize the Mutakallimun Ash’ariyah and his followers especially Imam Al-Ghazali. Ibn Rusyd also criticized Ibn sina and Zahiriyah group with the method they used. There was confusion for the answer to who they presented regarding religious and philosophical problems. While there were many problems with their views especially in their books. This article used the library research method which uses literature either in the form of books, or notes from previous research reports. While the sources of this research there are two sources as primary source and secondary sources. This result of this research revealed that Ibn Rushd’s philosophy critical method from authentic sources related to the problem. Although, by the use of various sources used, it is hoped there will be a new finding related to demonstrative method initiated by Ibn Rushd in refuting the arguments of rhetorical and dialectical groups which are not deep, explicit, and simple. As well as providing the new formulas that are fresher and more varied concerning the answer about the problems of religion and philosophy.
Perbandingan Konstruktivis dan Parennialis dalam Menjelaskan Pengalaman Mistik
Authors: Ilham Maulana  
Published: April 2023

In the discourse of philosophy of mysticism, there are at least two opposing views in explaining the expression of mystical experience, namely constructivist and perennialist. The constructivist views that mystical expression is closely related to the mystical tradition that originates so that the symbols used cannot be separated from tradition. This relates to the cognitive qualities possessed by mystics which shape the reality they find. Meanwhile, the perennialist argues that mystical expressions can be separated from tradition, so mystics often use symbols that are universal and cross-tradition. Discovered reality transcends cognitive influence. This article will analyse the comparison of the two views. The method used in this research is comparative analysis to find a middle ground that the two views are possible to juxtapose. I found a meeting point between the two views is the issue of ineffability or the unspeakable nature which is one of the characteristics of mystical experience. This problem shows that the relationship between experience and understanding in the case of spiritual experience is so complex. There are facts that are experienced but cannot be expressed so that mystics choose to remain silent or make paradoxical expressions. Therefore, the solution given is the ineffability character of mystical experience which cannot be ignored by constructivists and at the same time does not show that mystical experience is a pure experience as perennialist claim.
Keywords : Constructivist, ineffability, mystical experience, mystical expression, parennialist
FoMO (Fear of Missing Out) Among Youth Viewed From Herbert Marcuse’s Perspective
Authors: Siti Amallia  
Published: April 2023

Following the trend seems to be a benchmark for teenagers in determining the extent of their level of association. To be recognized as slang teenagers, they are not infrequently willing to leave their identity. Excessive anxiety arises when he feels left behind with precious moments that are worldly. This condition is then associated with self-esteem and self-confidence, especially those involving peers. The focus of the study in this research is FoMO behavior(Fear of Missing Out) in adolescents reviewed fromHerbert Marcuse's perspective to find out the fundamental causes behind the anxiety experienced by adolescents due to social media. This research is (Library Research) using several sources such as books, journals and the internet. The methods used include descriptive, analytical, and interpretive methods to connect neo marxism theory with contemporary problems. From the results of the study, it was found that concerns about other people's judgments and good relations with their peers made teenagers lose their original self-identity. The emergence of anxiety that leads to an attitude of insecurity begins to appear when a teenager does not know himself as a whole. Generally, feelings of anxiety in adolescents are related to uploads on social media. Through his analysis, Herbert Marcuse, a neo marxism figure, sees the characteristics of a one-dimensional society that can be related to the FoMO phenomenon among teenagers, namely about false needs and images. Adolescents with FoMO tendencies have difficulty in interpreting themselves in substance. They mostly get stuck at the level of form and follow other people. The orientation of free human beings has deviated far from the order of life. So there needs to be a revolution of thought so that teenagers can better understand how to behave, not just follow trends .
Keywords : FoMO, youth, social media, Herbert Marcuse, Marxism
Ivabradine acutely improves cardiac Ca handling and function in a rat model of Duchenne muscular dystrophy
Authors: Szabo Petra Lujza , Marksteiner Jessica , Ebner Janine , Dostal Christopher , Podesser Bruno K. , Sauer Jakob , Kubista Helmut , Todt Hannes , Hackl Benjamin , Koenig Xaver , Kiss Attila , Hilber Karlheinz 
Published: April 2023

AbstractThe muscular dystrophies caused by dystrophin deficiency, the so‐called dystrophinopathies, are associated with impaired cardiac contractility and arrhythmias, which considerably contribute to disease morbidity and mortality. Impaired Ca handling in ventricular cardiomyocytes has been identified as a causative factor for complications in the dystrophic heart, and restoration of normal Ca handling in myocytes has emerged as a promising new therapeutic strategy. In the present study, we explored the hypothesis that ivabradine, a drug clinically approved for the treatment of heart failure and stable angina pectoris, improves Ca handling in dystrophic cardiomyocytes and thereby enhances contractile performance in the dystrophic heart. Therefore, ventricular cardiomyocytes were isolated from the hearts of adult dystrophin‐deficient DMDmdx rats, and the effects of acutely applied ivabradine on intracellular Ca transients were tested. In addition, the drug's acute impact on cardiac function in DMDmdx rats was assessed by transthoracic echocardiography. We found that administration of ivabradine to DMDmdx rats significantly improved cardiac function. Moreover, the amplitude of electrically induced intracellular Ca transients in ventricular cardiomyocytes isolated from DMDmdx rats was increased by the drug. We conclude that ivabradine enhances Ca release from the sarcoplasmic reticulum in dystrophic cardiomyocytes and thereby improves contractile performance in the dystrophic heart.
PI3K/AKT/mTOR pathway and its related molecules participate in PROK1 silence-induced anti-tumor effects on pancreatic cancer
Authors: Wang Feng , Yan Xiaogang , Hua Yongqiang , Song Jianjun , Liu Di , Yang Chun , Peng Fei , Kang Fuping , Hui Yongfeng 
Published: April 2023

Abstract
The PI3K/AKT/mTOR (phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin) pathway can be initiated by PROK1 (prokineticin 1), but its effect and mechanism of action in pancreatic carcinoma (PC) are not fully understood. In this study, we elucidated the roles of PROK1 and its related molecules in PC in vivo. PANC-1 cells with PROK1 knockdown were injected into BALB/c nude mice. The growth and weight of the tumor were monitored and measured, which was followed by TUNEL (terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling), immunohistochemical staining, and hematoxylin and eosin staining. The key proteins related to proliferation, apoptosis, and the PI3K/AKT/mTOR pathway were determined by Western blotting. We also used public databases to identify the molecules related to PROK1. The reduction of PROK1 inhibited angiopoiesis and promoted apoptosis in vivo. PCNA-1, cyclin D1, and Bcl-2 decreased considerably, while Bax and cleaved caspase-3 increased significantly after PROK1 inhibition. The PI3K/AKT/mTOR signal inhibition was also closely associated with PROK1 knockdown. The possible related molecules of PROK1, such as von Willebrand factor, were screened and considered to be involved in the aberrant activation of PI3K/AKT. In conclusion, PROK1 knockdown significantly prevented tumor growth and promoted apoptosis of human PC cells in vivo, where the PI3K/AKT/mTOR pathway was probably inhibited. Therefore, PROK1, along with its related molecules, might be important targets for PC therapy.
The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy
Authors: Xin Yanbao , Lin Guojiao , Hua Tianbao , Liang Jianmin , Sun Tianmeng , Wu Xuemei 
Published: April 2023

Abstract
The cytoskeleton plays an important role in epilepsy; however, the mechanism is unknown. Therefore, this study aimed to reveal the mechanism of cytoskeletal proteins in epilepsy by investigating the expression of cytoskeletal proteins and synaptophysin (SYP) in mice at 0, 3, 6, and 24 h, 3 days, and 7 days in a kainic acid (KA)-induced epileptic model. Our results demonstrated that the expression of F-actin decreased significantly between 3 and 6 h, 6 and 24 h, and 24 h and 3 days (P < 0.05). Meanwhile, the expression of the neurofilament light chain, neurofilament medium chain, and neurofilament heavy chain subunits was significantly decreased (P < 0.001) at 3 h after the KA injection compared to the KA 0 h group, followed by an elevation at 6 h and a further decrease at 24 h compared to at 6 h. SYP expression was significantly decreased between 0 and 3 h as well as between 3 and 6 h (P < 0.05). At 24 h, the level was increased compared to at 6 h and continued to increase at 3 days after the KA injection. Thus, we propose that cytoskeletal proteins may be involved in the pathogenesis of epilepsy.
Highly sensitive tandem mass spectrometric measurement of serum estradiol without derivatization and pediatric reference intervals in children and adolescents
Authors: Di Meo Ashley , Yazdanpanah Mehrdad , Higgins Victoria , Nichols Matthew , Bohn Mary Kathryn , Tan Agnes , Zainab Shazina , Sepiashvili Lusia , Adeli Khosrow 
Published: April 2023

Abstract

Objectives
Monitoring estradiol (E2) is important for determining the onset of pubertal development as well as in the evaluation of girls with precocious puberty. However, E2 measurement remains an analytical challenge in children, who have lower circulating levels. We developed and evaluated a simple and sensitive LC-MS/MS procedure for serum E2 quantification in pediatric populations and established age- and sex-specific pediatric reference intervals.

Methods
Residual patient serum samples were used to evaluate the analytical performance of our in-house LC-MS/MS E2 assay. The evaluation included accuracy, precision, linearity, functional sensitivity (LLoQ), and method comparison. Age- and sex-specific pediatric E2 reference intervals were also established from a cohort of 405 healthy children (birth to 18 years) recruited with informed consent. Age- and sex-specific differences were assessed, and outliers were removed. Reference intervals were established using the robust method.

Results
The assay imprecision was <5.3 %. Assay linearity ranged from 13.7 to 1923.3 pmol/L. The LLoQ corresponding to a CV of 20 % was determined to be 8.9 pmol/L. Bland-Altman analysis revealed a mean bias of 29.3 pmol/L or 9.1 % between our LC-MS/MS E2 assay and an external reference laboratory measuring E2 by LC-MS/MS.

Conclusions
Our LC-MS/MS E2 assay shows acceptable accuracy, precision, functional sensitivity (LLoQ), and linearity for E2 quantification. Our LC-MS/MS E2 assay also showed good agreement with an external reference laboratory measuring E2 by LC-MS/MS. In addition, using CALIPER samples, we established robust age- and sex-specific pediatric E2 reference intervals to improve accuracy of test result interpretation and clinical decision making.
High stability with low polarization and confinement loss based new structure of photonic crystal fiber waveguide profile
Authors: Zuhayer Asif , Reddy Mittamidi Madhusudhan , Kak Anwer Twana Mohammed , Ahammad Shaik Hasane , Inthiyaz Syed , Hossain Md. Amzad , Rashed Ahmed Nabih Zaki , Hakim Rabab , Daher Malek G. , Zyoud Samer H. 
Published: April 2023

Abstract
Nowadays ethanol is broadly used chemical item in various industrial purpose. So, detection of this organic chemical has become very important task in industrial basis. In this paper, a hexagonal core PCF has constructed in which silica is used as base material. A finite element method is applied and mesh analysis has been done for investigating boundary conditions of proposed PCF sensor. After simulation, 59.48 % sensitivity and an ignorable loss of confinement which is 8·956020 × 10−13 cm−1 at 2.5 THz frequency has been gained. Focusing on easy construction of fiber, conventional fabrication procedures are attainable. Having satisfactory waveguiding attributes, the proposed sensor can be applicable effectively for sensing ethanol and also polarization-based applications of terahertz waves.
Optical communications with guided wave fibers with rectangular cladding for fuel adulteration detection
Authors: Ferdous A. H. M. Iftekharul , Reddy Mittamidi Madhusudhan , Anwer Twana Mohammed Kak , Anower Md. Shamim , Jain Prince , Musha Ahmmad , Islam Md. Ariful , Ahammad Shaik Hasane , Hossain Md. Amzad , Rashed Ahmed Nabih Zaki , Ibrahim Hassan 
Published: April 2023

Abstract
Fuel quality has a significant impact on the lifespan and smooth operation of petroleum engines. Many dishonest merchants mix lower priced oil/ingredients with petroleum products to increase their profit. To solve this problem, a terahertz waveguide-based fuel adulteration sensor that can detect the presence of kerosene in gasoline is proposed. The design procedure is performed by large elliptical hollow core photonic crystal fiber including rectangular cladding. In our study, the used sensor’s performance is investigated and FEM is also used for performing numerical analysis. Our used sensor achieved a maximum 80.34% sensitivity with a negligible total loss having 3.74 × 10−2 cm−1 during 2.8 THz optimum operating frequency conditions which are very impressive. Additionally, under ideal circumstances, the used sensor attained a sound birefringence of 0.01 and 0.034 ranging numerical aperture. The proposed sensor’s structure is quite simple which might make the fabrication process easy. Furthermore, because of the higher sensitivity and guiding properties, the sensor will be an important part of real-life applications in the forthcoming years.
Yiyang Xiang vowel quality: Comparability across two recording media
Authors: Sevilla Robert Marcelo 
Published: April 2023

AbstractCurrent events have necessitated the sacrifice of some degree of recording quality in order to reach inaccessible or faraway areas; for instance, using video conferencing software like Zoom for recording rather than traditional in-person microphone or sound booth recording. This then leads to the question: can Zoom-recorded data be used more or less interchangeably with standard recording procedures? The present research is an analysis of vowel acoustics in the Yiyang dialect of Xiang (Sinitic), comparing across two recording mediums: one online (Zoom) and another in person (sound booth). Researching Xiang varieties has been made increasingly difficult during the pandemic. This study analyzes two recordings retelling the events of the Pear Stories video, performed by a speaker of Yiyang Xiang (female, 24, college-educated), one recorded in the sound booth at the University of Hong Kong and another recorded through Zoom using a laptop microphone. Acoustic features analyzed include F1, F2, and F3. Preliminary findings suggest that while F1 is fairly comparable between the two recordings, the higher two formants are altered in ways that question the comparability of Zoom-recorded versus sound booth-recorded vowels. However, results improve considerably if formants are collected manually, suggesting that some recoverability is possible.
Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
Authors: Hu Xue , Guo Baoliang , Sun Tong , Wang Wan 
Published: April 2023

Abstract
Considering the role of glycolysis inhibition as a novel therapeutic strategy for cancer, including breast cancer (BC), we wondered whether glycolysis could affect BC progression by regulating transmembrane O-mannosyltransferase-targeting cadherins 3 (TMTC3). Following the intervention, lactic acid production in BC cells was monitored, and viability, proliferation, and apoptosis assays were performed. The expressions of TMTC3 and endoplasmic reticulum (ER) stress- and apoptosis-related factors Caspase-12, C/EBP homologous protein (CHOP), glucose-regulated protein 78 (GRP78), B-cell lymphoma-2 (Bcl-2), and Bcl-2 associated X (Bax) were quantified. TMTC3 was lowly expressed in BC tissue and cell. The promotion of glycolysis via glucose represses TMTC3 expression and apoptosis yet enhances lactic acid production and growth of BC cell, along with promoted levels of Caspase-12, CHOP, GRP78, and Bcl-2 yet repressed level of Bax, while the contrary results were evidenced after 2-deoxyglycouse intervention. Overexpressed TMTC3 additionally abrogated the effects of glycolysis on increasing the viability and proliferation yet inhibiting the apoptosis of BC cells, with the increased expressions of Caspase-12, CHOP, and GRP78, and Bcl-2 yet decreased level of Bax. Collectively, inhibiting glycolysis restrained the growth and attenuated the ER stress of BC cell by regulating TMTC3.
Effect of calcium on niobium solubility in alkaline solutions
Authors: Ohira Saki , Abe Takeyasu , Iida Yoshihisa 
Published: April 2023

Abstract
The solubility of niobium-94 (94Nb) in calcium alkaline solutions is one of the important parameters in safety assessment of intermediate-depth disposal which are assumed to use cementitious materials. Nb solubility and solubility-limiting solid phases of Nb in these systems remain unclear. The oversaturation solubility experiments were performed systematically in the 0.001–0.1 mol dm−3 (M) CaCl2 solutions under alkali conditions, and the characterization of precipitated solid phase controlling Nb solubility was conducted. The negative dependence of Nb solubilities on pH and calcium (Ca) concentration was observed in solubility experiments, and the Ca/Nb molar ratio of precipitated solid phase was 0.66. The pH and Ca dependence of Nb solubilities was reproduced by the reaction with Nb aqueous species Nb(OH)6
− and Ca–Nb oxide with the Ca/Nb ratio of 0.66, e.g., Ca4Nb6O19 (am). With increasing pH, Nb concentrations in the 0.001–0.1 M CaCl2 solutions were significantly lower than those calculated from thermodynamic data without Ca–Nb solid. This work provides systematic evidence that the presence of Ca clearly affects Nb solubility. Since calcium is a major component of groundwater and cement pore water, the Ca–Nb solid phase should be considered in the Nb solubility assessment.