bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposomal Drug Delivery System as an Emerging Technique for Treatment
of “Neurodegenerative Diseases”
Authors: Agiwale Bharat Tukaram , Jadhav Abhish Bhagwan , Kshirsagar Sanjay Jayprakash , Bele Mrudula Hemant , Sonawane Chetan Ramrao , Kakad Smita Prakash , Ahirrao Sapana Prabhakar 
Published: February 2023

Abstract::
In the last decade, the onset of neurodegenerative diseases (ND) has been strongly wide-spread due to the rapid increase in the world population. There are many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, spinal muscular atrophy, Levy body disease, etc. Alzheimer’s disease and Parkinson’s disease are most commonly found. Neurodegenerative diseas-es occur due to the degradation of neurons in the brain and the spinal cord. The diagnosis of both diseases has increased, however, the successful treatment is still very limited because of the lower ability of the drug to cross the blood-brain barrier (BBB). It is a big challenge to deliver the drug to the brain, because only small and lipid-soluble agents cross the BBB, by considering this assump-tion, the liposomal drug delivery system is considered one of the effective treatments in neuro-degenerative diseases. Liposomes are considered to be an ideal carrier as they are flexible, biocom-patible, and can carry different types of therapeutic molecules across the BBB. This review focus on the potential use of lipid delivery system in the treatment of neurodegenerative diseases and the ap-plication of liposomes in Alzheimer's disease and Parkinson’s disease.
The Use of Antivirals against COVID-19 Infection will Reduce the Number
of Fatalities in Australia
Authors: Boretti Alberto 
Published: February 2023

Abstract:
Australia finally permitted in July 2022 the use of oral antivirals against COVID-19. For the
previous 2.5 years, the local bureaucrats have prevented medical doctors to prescribe the antivirals successfully
used in other jurisdictions. Suddenly, they changed their mind, even if the opening of the restrictions
was limited to only two products not known to be the most effective, nor the cheapest, in between
the many available.
Influences on Patient Uptake of and Engagement With the National Health Service Digital Diabetes Prevention Programme: Qualitative Interview Study
Authors: Ross Jamie , Cotterill Sarah , Bower Peter , Murray Elizabeth 
Published: February 2023

Background
Digital diabetes prevention programs (digital-DPPs) are being implemented as population-based approaches to type 2 diabetes mellitus prevention in several countries to address problems with the uptake of traditional face-to-face diabetes prevention programs. However, assessments of digital-DPPs have largely focused on clinical outcomes and usability among those who have taken them up, whereas crucial information on decision-making about uptake (eg, whether a user downloads and registers on an app) and engagement (eg, the extent of use of an app or its components over time) is limited. Greater understanding of factors that influence uptake and engagement decisions may support large-scale deployments of digital-DPPs in real-world settings.

Objective
This study aimed to explore the key influences on uptake and engagement decisions of individuals who were offered the National Health Service Healthier You: Digital Diabetes Prevention Programme (NHS-digital-DPP).

Methods
A qualitative interview study was conducted using semistructured interviews. Participants were adults, aged ≥18 years, diagnosed with nondiabetic hyperglycemia, and those who had been offered the NHS-digital-DPP. Recruitment was conducted via 4 providers of the NHS-digital-DPP and 3 primary care practices in England. Interviews were conducted remotely and were guided by a theoretically informed topic guide. Analysis of interviews was conducted using an inductive thematic analysis approach.

Results
Interviews were conducted with 32 participants who had either accepted or declined the NHS-digital-DPP. In total, 7 overarching themes were identified as important factors in both decisions to take up and to engage with the NHS-digital-DPP. These were knowledge and understanding, referral process, self-efficacy, self-identity, motivation and support, advantages of digital service, and reflexive monitoring. Perceptions of accessibility and convenience of the NHS-digital-DPP were particularly important for uptake, and barriers in terms of the referral process and health care professionals’ engagement were reported. Specific digital features including health coaches and monitoring tools were important for engagement.

Conclusions
This study adds to the literature on factors that influence the uptake of and engagement with digital-DPPs and suggests that digital-DPPs can overcome many barriers to the uptake of face-to-face diabetes prevention programs in supporting lifestyle changes aimed at diabetes prevention.
A Personalized Mobile Cessation Intervention to Promote Smokers From the Preparation Stage to the Action Stage: Double-blind Randomized Controlled Trial
Authors: Lin Haoxiang , Wang Ying , Xing Yanling , Han Yinglian , Zhang Chengqian , Luo Ting , Chang Chun 
Published: February 2023

Background
Most mobile cessation studies have found that such interventions have a higher quitting rate than interventions providing minimal smoking cessation support. However, why such interventions are effective has been almost unstudied by researchers.

Objective
This paper describes the principles of the personalized mobile cessation intervention-based WeChat app and used generalized estimated equations to assess why a personalized mobile cessation intervention was more likely to promote smokers from the preparation stage to the action stage than a nonpersonalized intervention.

Methods
This is a 2-arm, double-blind, randomized controlled trial in five cities in China. The intervention group received a personalized mobile cessation intervention. The control group received a nonpersonalized SMS text message smoking cessation intervention. All information was sent by the WeChat app. The outcomes were the change in protection motivation theory construct scores and the change in transtheoretical model stages.

Results
A total of 722 participants were randomly assigned to the intervention or control group. Compared with those who received the nonpersonalized SMS text message intervention, smokers who received the personalized intervention presented lower intrinsic rewards, extrinsic rewards, and response costs. Intrinsic rewards were determinants of stage change, thus explaining why the intervention group was more likely to promote smokers from the preparation stage to the action stage (odds ratio 2.65, 95% CI 1.41-4.98).

Conclusions
This study identified the psychological determinants at different stages to facilitate smokers moving forward to the next stage of quitting behavior and provides a framework to explore why a smoking cessation intervention is effective.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2100041942; https://tinyurl.com/2hhx4m7f
Emprendimiento y género: su análisis desde la perspectiva de la Teoría de la Conducta Planificada
Authors: Vera Muñoz José Gerardo , Vera Muñoz María Antonieta Monserrat , Martínez Méndez Rafaela 
Published: February 2023

Resumen
Objetivo: analizar si entre los estudiantes de educación superior existe un impacto relevante en la intención emprendedora que sea atribuible a la diferencia de género, aplicando el modelo de la Teoría de la Conducta Planificada modificado por Vamvaka et al. (2020).
Diseño metodológico: se tomó una muestra a un grupo de estudiantes de la Facultad de Contaduría Pública (FCP) de la Benemérita Universidad Autónoma de Puebla (BUAP), con estos datos se realizó un análisis descriptivo que se complementó con una prueba de hipótesis para muestras apareadas.
Resultados: a nivel descriptivo, el promedio de los estudiantes fue superior al promedio de las estudiantes en cada una de las variables del modelo de Vamvaka et al. (2020). Sin embargo, las pruebas de hipótesis arrojaron que únicamente en la variable control conductual percibido, se encontró evidencia estadística significativa para suponer que los promedios de los estudiantes varones son superiores a los promedios de las estudiantes mujeres.
Limitaciones: el tamaño de la muestra de 70 estudiantes; sólo se incluyeron estudiantes de las licenciaturas que se ofertan en la FCP de la BUAP.
Hallazgos: la diferencia de género únicamente resultó relevante en el control conductual percibido y no tuvo un efecto significativo en la actitud y en la intención emprendedora. Los puntajes mayores y menores tanto de las estudiantes como de los estudiantes se obtuvieron para la variable actitud y la variable intención respectivamente, lo que permite suponer que existe una percepción agradable y optimista por la actividad emprendedora, pero escaso interés y compromiso con su ejecución.
Journal Direction and Call for Papers
Authors: Samuels Janet A. 
Published: February 2023

ABSTRACT
Issues in Accounting Education (IAE) has a longstanding reputation for disseminating high-quality educational research and cases. As the new senior editor, I want to continue this important mission of IAE and reflect the increasingly changing needs of the academy. To that end, I provide a brief commentary on directions for the journal and a general call for papers.
Ultra-Processed Food Consumption and Risk of Type 2 Diabetes: Three Large Prospective U.S. Cohort Studies
Authors: Chen Zhangling , Khandpur Neha , Desjardins Clémence , Wang Lu , Monteiro Carlos A. , Rossato Sinara L. , Fung Teresa T. , Manson JoAnn E. , Willett Walter C. , Rimm Eric B. , Hu Frank B. , Sun Qi , Drouin-Chartier Jean-Philippe 
Published: February 2023

OBJECTIVE
We examined the relationship between ultra-processed food (UPF) intake and type 2 diabetes (T2D) risk among 3 large U.S. cohorts, conducted a meta-analysis of prospective cohort studies, and assessed meta-evidence quality.

RESEARCH DESIGN AND METHODS
We included 71,871 women from the Nurses’ Health Study, 87,918 women from the Nurses’ Health Study II, and 38,847 men from the Health Professional Follow-Up Study. Diet was assessed using food frequency questionnaires and UPF was categorized per the NOVA classification. Associations of total and subgroups of UPF with T2D were assessed using Cox proportional hazards models. We subsequently conducted a meta-analysis of prospective cohort studies on total UPF and T2D risk, and assessed meta-evidence quality using the NutriGrade scoring system.

RESULTS
Among the U.S. cohorts (5,187,678 person-years; n = 19,503 T2D cases), the hazard ratio for T2D comparing extreme quintiles of total UPF intake (percentage of grams per day) was 1.46 (95% CI 1.39–1.54). Among subgroups, refined breads; sauces, spreads, and condiments; artificially and sugar-sweetened beverages; animal-based products; and ready-to-eat mixed dishes were associated with higher T2D risk. Cereals; dark and whole-grain breads; packaged sweet and savory snacks; fruit-based products; and yogurt and dairy-based desserts were associated with lower T2D risk. In the meta-analysis (n = 415,554 participants; n = 21,932 T2D cases), each 10% increment in total UPF was associated with a 12% (95% CI 10%–13%) higher risk. Per NutriGrade, high-quality evidence supports this relationship.

CONCLUSIONS
High-quality meta-evidence shows that total UPF consumption is associated with higher T2D risk. However, some UPF subgroups were associated with lower risk in the U.S. cohorts.
Ultra-processed food consumption and risk of type 2 diabetes: three large prospective U.S. cohort studies.
Authors: Chen Spangling , Khandpur Neha , Desjardins Clémence , Wang Lu , Monteiro Carlos , Rossato Sinara Laurini , T. Fung Teresa , Manson JoAnn E. , Willett Walter , B Rimm Eric , B. Hu Frank , Sun Qi , Drouin-Chartier Jean-Philippe 
Published: February 2023

<p> </p>
<p><strong>Objective: </strong>We examined the relationship between ultra-processed food (UPF) intake and type 2 diabetes (T2D) risk among 3 large U.S. cohorts, conducted a meta-analysis of prospective cohort studies, and assessed meta-evidence quality.</p>
<p><strong>Research design and methods: </strong>We included 71,871 women from Nurses’ Health Study (NHS), 87,918 women from NHSII, and 38,847 men from Health Professional Follow-Up Study. Diet was assessed using food frequency questionnaires and UPF were categorized per the Nova classification. Associations of total and subgroups of UPF with T2D were assessed using Cox proportional hazards models. We subsequently conducted a meta-analysis of prospective cohort studies on total UPF and T2D risk, and assessed meta-evidence quality using NutriGrade.</p>
<p><strong>Results: </strong>Among the U.S. cohorts (5,187,678 person-years; 19,503 T2D cases), the hazard ratio for T2D comparing extreme quintiles of total UPF intake (percent of grams/day) was 1.46 (95% CI: 1.39, 1.54). Among subgroups, refined breads; sauces, spreads and condiments; artificially-and sugar-sweetened beverages; animal-based products; and ready-to-eat mixed dishes were associated with higher risk. Cereals; dark and whole-grain breads; packaged sweet and savory snacks; fruit-based products; and yogurt and dairy-based desserts were associated with lower risk. In the meta-analysis (415,554 participants; 21,932 T2D cases), each 10% increment in total UPF was associated with a 12% (95% CI: 10%, 13%) higher risk. Per NutriGrade, high quality evidence supports this relationship.</p>
<p><strong>Conclusion: </strong>High quality meta-evidence shows that total UPF consumption is associated with higher T2D risk. However, some UPF subgroups were associated with lower risk in the U.S. cohorts.</p>
The Prevalence of Stigmatizing Beliefs towards Mental Illness and Mental Health Nursing among Third-Year Undergraduate Nursing Students in Riyadh, Saudi Arabia: A Review
Authors: Alharbi Raghad B. 
Published: February 2023

Background: Stigmatizing beliefs towards mental illness and mental health nursing are a global concern, as they can impact the quality of care provided to patients. In Saudi Arabia, nursing students undergo 16 weeks of clinical training in mental health facilities, which may influence their attitudes towards mental illness and mental health nursing.

Aim: The main aim of this review was to examine the prevalence of stigmatizing beliefs towards mental illness and mental health nursing among third-year undergraduate nursing students in Riyadh, Saudi Arabia.

Methodology: A comprehensive search of relevant databases was conducted to identify studies that examined the attitudes of nursing students towards mental illness and mental health nursing in Riyadh, Saudi Arabia. The search was limited to studies published in English between 2015 and 2022.

Main Findings: The literature review identified several studies that examined the attitudes of nursing students towards mental illness and mental health nursing in Riyadh, Saudi Arabia. These studies found that stigmatizing beliefs towards mental illness are prevalent among nursing students in Saudi Arabia. Factors such as cultural norms, personal experience, and professional experience were identified as contributing to these attitudes. Educational interventions, including lectures, videos, and direct contact, may be effective in addressing stigma and improving attitudes towards mental illness.

Conclusion and Recommendations: Stigmatizing beliefs towards mental illness and mental health nursing are prevalent among third-year undergraduate nursing students in Riyadh, Saudi Arabia. Factors such as cultural norms, personal experience, and professional experience may contribute to these attitudes. Educational interventions, including lectures, videos, and direct contact, may be effective in addressing stigma and improving attitudes towards mental illness. Further research is needed to better understand the factors that contribute to stigmatizing beliefs and to identify the most effective interventions for reducing stigma among nursing students in Saudi Arabia.
Pelatihan penulisan artikel ilmiah sebagai suplemen bahan ajar untuk MGMP sejarah kabupaten Lampung Selatan
Authors: Arif Suparman , Perdana Yusuf , Pratama Rinaldo Adi 
Published: February 2023

Kompetensi guru sejarah sebagai pendidik salah satunya dituntut untuk mengetahui permasalahan yang dihadapi di dalam kelas, salah satunya adalah kebutuhan suplemen bahan ajar yang relevan bagi siswa. Peningkatan kompetensi Guru sejarah perlu dilakukan, mengingat banyaknya potensi sejarah lokal sebagai materi pembelajaran sejarah. Terbatasnya bahan ajar yang disediakan oleh pemerintah pusat untuk pembelajaran sejarah di daerah, akan berdampak pada hasil belajar siswa. Artikel ilmiah dapat dijadikan salah satu suplemen bahan ajar guru sejarah di Provinsi Lampung, khususnya MGMP Sejarah Lampung Selatan. Musyawarah Guru Mata Pelajaran (MGMP) di Kabupaten Lampung Selatan merupakan forum yang efektif dalam mewadahi berbagai guru sejarah yang sangat berpotensi dalam mewadahi berbagai permasalahan guru sejarah. Metode yang digunakan dalam program pengabdian ini adalah sosialisasi dengan bentuk presentasi yang dilakukan oleh tim pengabdian dan pelatihan secara langsung dengan bentuk pendampingan kepada peserta pengabdian. Instrument yang digunakan adalah Materi yang tersaji dalam bentuk power point, contoh artikel ilmiah sebagai suplemen bahan ajar, dan Lembar evaluasi kegiatan dalam bentuk pretest dan posttest. Analisis data dilakukan secara kualitatif. Hasil pengabdian menunjukkan bahwa kegiatan pengabdian Penulisan Artikel Ilmiah Sebagai Suplemen Bahan Ajar Untuk MGMP Sejarah Kabupaten Lampung Selatan terlaksana dengan baik dan meningkatnya kreativitas dan kompetensi guru terhadap Artikel Ilmiah yang bermanfaat sebagai suplemen bahan ajar ajar.
Pendampingan orang tua anak berkebutuhan khusus di rusunawa Jatinegara Kaum Jakarta Timur
Authors: Nara Hartini , Purnamawati Siti Nuraini , Firdausy Rahmarini , Sajidah Hana , Jasmine Julia , Nugraha Hadha Aditya 
Published: February 2023

Rusunawa Jatinegara Kaum merupakan sebuah perumahan sederhana di Kecamatan Pulogadung, Jakarta Timur. Di Rusunawa ini, terdapat setidaknya 51 anak berkebutuhan khusus dengan beberapa hambatan yang berbeda. Di samping itu, para orang tua dari anak berkebutuhan khusus di sini tidak memiliki pengetahuan yang cukup dalam mengasuh, menangani, dan memberikan pendidikan yang tepat bagi anak-anak mereka. Penyebabnya antara lain minimnya pengetahuan dan informasi mengenai penanganan anak berkebutuhan khusus dan pendidikannya, tidak menyadari bahwa anak mereka berkebutuhan khusus, latar belakang pendidikan orang tua yang rendah sehingga mengesampingkan pendidikan anak, kemampuan komunikasi yang kurang baik, serta kondisi ekonomi yang berdampak pada pendidikan anak. Kegiatan pendampingan ini bertujuan untuk memberi edukasi bagi orang tua anak berkebutuhan khusus dalam menangani, mendidik, mengasuh, serta mendukung keterampilan dan kemandirian anak berkebutuhan khusus. Metode yang digunakan adalah pendampingan berupa workshop, focus group discussion (FGD), serta konsultasi. Luaran yang dihasilkan dari kegiatan ini antara lain terdapat perubahan positif walaupun belum signifikan pada orang tua anak berkebutuhan khusus dari segi penanganan, meningkatkan kesadaran orang tua dalam mendampingi anak berkebutuhan khusus, membangun komitmen orang tua dalam membersamai dan mendampingi anak berkebutuhan khusus, serta terjalin kemitraan antara Prodi Pendidikan Khusus Fakultas Ilmu Pendidikan Universitas Negeri Jakarta dengan warga Rusunawa Jatinegara Kaum.
Pelatihan keterampilan wirausaha dalam pemangkasan komersial pada rambut pria
Authors: Arisa Ma’rifani Fitri 
Published: February 2023

Program Pengabdian Masyarakat (PKM) bertujuan untuk memberikan pengetahuan, keterampilan dan pengalaman dalam membangun usaha barber shop. Kurangnya pengetahuan dan keterampilan terhadap pemangkasan rambut pria menjadi hambatan dan kendala dalam mendirikan sebuah barber shop. Kegiatan PKM dimulai dengan pre-test untuk melihat kemampuan dasar terkait pengetahuan dan keterampilan masyarakat. Selanjutnya dilakukan pelatihan terkait pengetahuan dan keterampilan dalam membangun wirausaha barber shop. Selanjutnya pada akhir pelatihan diberikan post test tentang pengetahuan dan keterampilan dalam wirausaha barber shop. Tujuan dari post-tes untuk melihat apakah ada peningkatan pengetahuan dan keterampilan mengenai pendirian sebuah barber shop. Sehingga akhir dari pelatihan ini diharapkan dapat meningkatkan pengetahuan dan keterampilan dalam wirausaha barber shop. Hasil dari PKM menunjukkan peningkatan pengetahuan dan keterampilan masyarakat dalam membangun wirausaha barbershop.
Клинический случай применения биорегуляционной терапии у пациента, длительно страдающего болью в нижней части спины на фоне рекуррентного депрессивного расстройства
Authors: Тумуров Дмитрий 
Published: February 2023

В данном клиническом случае рассмотрен пациент с фибромиалгией, длительно страдающий болью в нижней части спины. В данном случае мы использовали мультидициплинарных подход к лечению: помимо стандартных обследований, мы предложили пройти опросник по здоровью (EQ-5D), шкалу депрессии Бека (BDI) и шкалу тревоги Спилбергера (STAI), для определения уровня тревоги и депрессии [Приложение 1].
Благодаря результатам опросников, был составлен соответствующий план лечения и наблюдения.
GROWTH, YIELD AND ABSORPTION OF CARBONDIOXIDE (CO2) POTENTIAL DAYAK ONION (Eleuteherine americana Merr) ON PEAT SOIL
Authors: Winarti Sih , Alpian Alpian , Jaya Herry Palangka 
Published: February 2023

The purpose of this study was to determine the growth, yield and the potential for carbondioxide absorption of dayak onion plants given four types of manure on peat soil. This experiment used a completely randomized design with four treatments and six replications. The treatments tried were chicken, swallow, cow, goat manure. The results showed that the type of manure had an effect on plant growth and yield. The growth of plant height and the number of leaves dayak onion planted on peat soil given cow and goat manure grew significantly higher and more the number of leaves, the lowest was found in dayak onion plants fed with swallow manure. The highest yield was obtained on dayak onion plants fertilized with 30 t ha-1 cow manure with a tuber weight of 41.50 g clump-1, with a larger tuber diameter, but the highest number of tubers was obtained in dayak onion plants fertilized by swallow manure with tubers diameter smaller. The highest weight of biomass, stored carbon and carbon dioxide absorption were 6.6; 3.3 and 12.11 t ha-1 found in dayak onion plants planted on peat soil given cow manure 30 t ha-1