bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Decentration of Plate-Haptic Toric Intraocular Lens on Postoperative Visual Quality
Authors: Diao Chunli , Lan Qianqian , Liao Jing , Lu Peng , Zhou Zhou , Li Lanjian , Zeng Siming , Yao Gang , Huang Wei , Chen Qi , Lv Jian , Tang Fen , Li Min , Xu Fan 
Published: March 2023

Abstract
Background: To evaluate the influence of decentration of plate-haptic toric intraocular lens (IOLs) on visual quality.
Methods: This study enrolled 78 eyes of 78 patients. Patients in group A were implanted with toric IOLs, and patients in group B were implanted with monofocal IOLs. All patients were divided into group A1 and B1 (decentration below 0.3mm) and group A2 and B2 (decentration above 0.3mm). The uncorrected distance visual acuity (UDVA), best corrected visual acuity (BCVA), modulation transfer function cutoff (MTF cutoff), objective scatter index (OSI), strehl ratio (SR), optical interference and patients’ satisfaction were measured in different pupils at three months postoperatively. The associations between decentration and visual quality were analyzed by Spearman correlation.
Results: There were no significant differences in decentration, UDVA, BCVA, MTF cutoff, OSI, SR, optical interference and patients’ satisfaction among subgroups. In group A2, the total higher order aberrations (tHOAs) at pupil sizes of 3 mm (P = 0.046), 5 mm (P = 0.014), spherical aberrations at pupil sizes of 3 mm (P = 0.011), 4 mm (P = 0.014), 5 mm (P = 0.000), secondary astigmatism at pupil sizes of 3 mm (P = 0.002), 4 mm (P = 0.005) were higher than in group B2. Compared to group A1, group A2 had higher spherical aberrations at pupil sizes of 4 mm (P = 0.042), 5mm (P = 0.001), 6 mm (P= 0.038), secondary astigmatism at pupil sizes of 3 mm (P = 0.013), 4mm (P = 0.005), 6 mm (P = 0.013). Group B2 has higher coma and secondary astigmatism than group B1 at 6-mm pupil (P = 0.014, P = 0.045). Significant positive correlations were found between spherical aberrations and the decentration of group A1 and A2 at 6-mm pupils.
Conclusion: The decentration negatively affected visual quality due to increased tHOAs, spherical aberrations, coma and secondary astigmatism aberrations, the influence become larger with increasing pupil diameter.
Can 3D Imaging Modeling Recognize Functional Tissue and Predict Liver Failure? A retrospective study based on 3D modelling of the major hepatectomies after hepatic modulation.
Authors: Vicente Emilio , Quijano Yolanda , Duran Hipolito , Diaz Eduardo , Fabra Isabel , Malave Luis , Ruiz Pablo , Pizzuti Giada , Naldini Chiara , De Nobili Giovanni , Caruso Riccardo , ferri valentina 
Published: March 2023

Abstract
Background: Thanks to the introduction of radiomics, 3d reconstruction can be able to analyse tissues and recognise true hypertrophy from non-functioning tissue in patients treated with major hepatectomies with hepatic modulation.The aim of this study is to evaluate the performance of 3D Imaging Modelling in predict liver failure.
Methods: Patients submitted to major hepatectomies after hepatic modulation at Sanchinarro University Hospital from May 2015 to October 2019 were analysed.
Three dimensional reconstruction was realised before and after surgical treatment. The volumetry of Future Liver Remnant was calculated, distinguishing in Functional Future Liver Remnant (FRFx) i.e. true hypertrophy tissue and Anatomic Future Liver Remnant (FRL) i.e. hypertrophy plus no functional tissue (edema/congestion) These volumeswere analysed in patients with and without post hepatic liver failure.
Results: Twenty-four procedures were realised (11 ALPPS and 13 PVE followed by major hepatectomy). Post hepatic liver failure grade B and C occurred in 6 patients. The ROC curve showed a better AUC for FRFxV (74%) with respect to FRLV (54%) in prediction PHLF>B. The increase of anatomical FRL (iFRL) was superior in the ALPPS group (120%) with respect to the PVE group (73%) (p=0,041), while the increase of functional FRFX (iFRFx) was 35% in the ALLPS group and 46% in the PVE group (p>0,05), showing no difference in the two groups.
Conclusion: The 3D reconstruction model can allow optimal surgical planning, and through the use of specific algorithms, can contribute to differential functioning liver parenchyma of the FLR.
Successful Aging in Turkey: Psychometric properties of the Turkish adapted Successful Aging Scale
Authors: Haugan Gørill , Korukcu Oznur , Kabukcuoglu Kamile , Tufan Ismail , Helvik Anne-Sofie 
Published: March 2023

Abstract
Introduction: With better living conditions and medical advances globally, the longevity of people is increasing worldwide, demonstrating the importance of successful aging.
Aim: To investigate the psychometric properties of the Turkish Successful Aging Scale (SAS) among older adults 60 years and older in Turkey.
Methods: Cross-sectional data were collected from 206 older individuals registered with an Active Senior Center between April and May 2019. Inclusion criteria were literate in Turkish, aged ≥60 years, no dementia, newly registered with the Active Senior Center, and volunteered to participate in the study.
Results: A low mean (SD) sum-score for the SAS 16.18 (5.15) revealed, with no significant association with age, income, marital status, working, and chronical illness. Principal Component Analysis indicated two factors explaining 54,75% of the variance. Confirmative Factor Analysis disclosed a poor fit, indicating misspecification. A model including 6 items and two dimensions was the most parsimonious and best fitting solution: χ2=14.487 (df=8), χ2/df=1.81, p=0.0001, RMSEA=0.063, p-value for test of close fit=0.0295, CFI=0.99, TLI=0.97, and SRMR 0.033. Composite reliability for the two dimensions were good and acceptable, respectively.
Conclusion: The validity and reliability of the Turkish SAS two-dimensional measurement-model is acceptable. However, some items seemed redundant plausibly due to translation and cultural aspects. Possibly, the SAS content developed in a western context is highly culturally sensitive; working further on the Turkish wording and validation is recommended. Moreover, Turkish health authorities should acknowledge a health promotion perspective supporting positive life behaviors among elderlies both at a system-oriented and an individual level.
A study on the direction of drug information service capacity development of Chinese medical staff: based on the perspective of drug information patients obtained and need
Authors: Huang Rong , Huang Yuankai , Liu Jiayuan , Chen Lei 
Published: March 2023

Abstract
Background
There are some gaps between the cultivation of drug information service competencies for medical staff and drug information patients need in China.
Objective
To investigate drug information patients obtained and need for further providing directions for the cultivation of drug information service competencies among medical staff in China from patients’ perspectives.
Methods
Adopted a stratified sampling method, a face-to-face survey was conducted nationwide to collect data on drug information patients obtained and need.
Results
A total of 1994 questionnaires from medical institutions in China were returned. Most of the drug information obtained by patients came from physicians, and different types of drug information were important to patients. Additionally, medical staff ignored the fact that patients had different needs for drug information due to age, gender, diagnosis and treatment status, and education level.
Conclusions
The cultivation of medical staff needs to increase the presence of nurses and pharmacists in drug information services, enhance the awareness of "patient-centered" services, and improve the ability to provide information services specific to the characteristics of patients.
Influence of exposure of customized dental implant abutments to different cleaning procedures: an in vitro study using AI-assisted SEM/EDS analysis
Authors: Hofmann Paul , Kunz Andreas , Schmidt Franziska , Beuer Florian , Duddeck Dirk 
Published: March 2023

Abstract
Purpose: Dental implant abutments are defined as medical devices by their intended use. Surfaces of custom-made CAD/CAM two-piece abutments may become contaminated during the manufacturing process in the dental lab. Inadequate reprocessing prior to patient care may contribute to implant-associated complications. Risk-adapted hygiene management is required to meet the requirements for medical devices.
Methods: A total of 49 CAD/CAM-manufactured zirconia copings were bonded to prefabricated titanium bases. One group was bonded, polished, and cleaned separately in dental laboratories throughout Germany (LA). Another group was left untreated (NC). Five groups received the following hygiene regimen: three-stage ultrasonic cleaning (CP and FP), steam (SC), argon-oxygen plasma (PL), and simple ultrasonic cleaning (UD). Contaminants were detected using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) and segmented and quantified using interactive machine learning (ML) and thresholding (SW). The data were statistically analysed using non-parametric tests (Kruskal-Wallis test, Dunn's test).
Results: Significant differences in contamination levels with the different cleaning procedures were found (p ≤ 0.01). The FP-NC/LA groups showed the most significant difference in contamination levels for both measurement methods (ML, SW), followed by CP-LA/NC and UD-LA/NC for SW and CP-LA/NC and PL-LA/NC for ML (p ≤ 0.05). EDS revealed organic contamination in all specimens; traces of aluminum, silicon, and calcium were detected.
Conclusions: Chemothermal cleaning methods based on ultrasound and argon-oxygen plasma effectively removed process-related contamination from zirconia surfaces. Machine learning is a promising assessment tool for quantifying and monitoring external contamination on zirconia abutments.
Exosomes-mediated transfer LINC00691 regulates the formation of CAFs and promotes the progression of gastric cancer
Authors: Xia Bin , Gu Xiuyu , Xu Tingting , Yan Meina , Huang Lan , Jiang Chun , Li Meifen , Zhai Guanghua , Zhang Guoping , Wu Jian , Zhou Yu , Sun Chunrong , Liang Wei 
Published: March 2023

Abstract
Objective
To find the expression pattern of serum exosomal LINC00691 in GC patients and the correlation between the level of serum exosomal LINC00691 and the pathology and prognosis of gastric cancer patients.
Methods
We treated normal fibroblasts (NFs) with LINC00691-rich GC cell culture supernatant or exosomes and detected the activation markers and biological functions of the fibroblasts.
Results
It was found that the level of LINC00691 was significantly increased, the cell proliferation and migration were noticeably enhanced, and the ability to accelerate GC cell proliferation and invasion was promoted after treated with GC exosomes, which means that the induced fibroblasts gained the properties of cancer-associated fibroblasts (CAFs). In addition, we found that knockdown of LINC00691 and the use of the JAK2/STAT3 signaling pathway inhibitor ruxolitinib effectively deprived the effects of exosome-containing GC cell supernatants on NFs.
Conclusion
Our study suggested that exosomal LINC00691 promoted the transformation from NFs to CAFs depending on JAK2/STAT3 signaling pathway as a potential diagnostic biomarker for GC.
Association between preoperative C-reactive protein to albumin ratio and late arteriovenous fistula dysfunction in hemodialysis patients: A cohort study
Authors: Hu Shouliang , Wang Runjing , Ma Tean , Lei Qingfeng , Yuan Fanli , Zhang Yong , Wang Dan , Cheng Junzhang 
Published: March 2023

Abstract
Arteriovenous fistula (AVF) dysfunction in hemodialysis (HD) patients is linked to high mortality and inflammation may play a role. We investigated the association between CAR and AVF dysfunction in a group of HD patients from China. We conducted a retrospective cohort study of 695 adults with end-stage renal disease (ESRD) receiving new AVF placement at a single center between 2011 and 2019. Multivariable Cox regression was used to examine the potential association between preoperative CAR and AVF dysfunction, defined as surgical or transluminal angioplasty intervention due to thrombosis or significant vessel diameter reduction. Among 695 HD patients with a new AVF, 212 (30.5%) experienced dysfunction during a median follow-up of 33 months. Adjusted multivariable Cox regression analysis found that a one-unit increase in CAR was associated with a 28% higher risk of AVF dysfunction. Those with CAR ≥ 0.146 had a 76% increased risk compared to those with CAR values between 0.035 and 0.146. The relationship between CAR and AVF dysfunction varied by placement site of internal jugular vein catheters, with significantly higher hazard ratios for ipsilateral placement. The interaction between CAR and catheter placement site was also significant (p-value: 0.004). Our study findings indicate that higher preoperative CAR is linked to an increased likelihood of AVF dysfunction in Chinese patients undergoing HD, especially when ipsilateral internal jugular vein catheters are placed. These results provide valuable insights for clinicians in identifying high-risk patients for AVF dysfunction.
SFA-GAN: Structure-frequency-aware generative adversarial network for underwater image enhancement
Authors: Zhang Yinghui , Liu Tingshuai , Zhao Bo , Ge Fengxiang 
Published: March 2023

Abstract
Influenced by light scattering, absorption and water impurities, the quality of underwater image is so poor that it poses a great challenge to underwater target detection, marine biological research and marine exploration. Thus, significant attention on underwater image enhancement (UIE) has been attracted for producing high quality visuality as if the underwater image was taken in-air without any structure, texture and color loss. To solve this issue, previous work mainly focus on supervised-learning with large amount of paired data, which is more demanding in practical application. Recent Cycle-GAN based UIE break through the dependence on paired data but easily trap in mapping ambiguity. Essentially, two-sided cycle-consistency is a bijection and only focuses on the pixel level, which is too restrictive and can not accurately express underwater scene structure. Besides, high frequencies in reference images tend to be eschewed by generator, making it difficult to synthesize authentic textures and colors of underwater images. We therefore propose a novel unconstrained UIE framework, structure-frequency-aware generative adversarial network (SFA-GAN), which not only accurately preserves the structure of low quality underwater images, but also captures the high frequencies of the reference images under unconstrained settings. Extensive experiments on datasets EUVP, UFO-120 and UIEB demonstrate that the proposed SFA-GAN can achieves state-of-art results on some metrics and produce more clear underwater images without sacrificing model complexity.
Textbook outcome in the surgical treatment of acute cholecystitis
Authors: Iseda Norifumi , Iguchi Tomohiro , Sasaki Shun , Itoh Shinji , Honboh Takuya , Yoshizumi Tomoharu , Sadanaga Noriaki , Matsuura Hiroshi 
Published: March 2023

Abstract
Background
Textbook Outcome (TO) is a novel composite measure of clinical outcomes that can be used to measure the quality of surgical outcomes. The aim of this cohort study was to propose TO criteria for laparoscopic cholecystectomy for acute cholecystitis and to identify reasons for TO failure and individual patient factors that predispose to failure.
Methods
We retrospectively analyzed data for 189 consecutive patients with acute cholecystitis who underwent laparoscopic cholecystectomy. TO was defined as laparoscopic cholecystectomy without conversion to open cholecystectomy, intraoperative complications, postoperative complications (Clavien–Dindo classification ≥ 2), prolonged length of stay (≥ 10 days), readmission within 30 days, or mortality. Demographic and clinical differences between patients with and without TO were compared using univariate and multivariate analyses.
Results
TO was achieved in 81% (n = 154) of 189 patients who underwent laparoscopic cholecystectomy for acute cholecystitis. Medical costs were lower in the TO-achieved group than in the TO-failure group. Factors associated with TO on univariate analysis were age, vascular disease, history of malignant tumor treatment, white blood cell count, hemoglobin, C-reactive protein, albumin, gallbladder perforation, and > 3 days since the onset of symptoms. Factors on multivariate analysis were age > 70 years, hemoglobin < 11.9 g/dl, and white blood cells > 18,000 / µl (all P < 0.05).
Conclusions
Applying TO to patients with acute cholecystitis allowed us to evaluate the overall quality of care related to hospitalization. TO may provide better assessment of the quality of care and help determine the treatment choice and reduce costs.
What touching you makes me feel - hedonic and autonomic responses in promoting an affective touch
Authors: Mazza Alessandro , Cariola Monia , Capiotto Francesca , Diano Matteo , Schintu Selene , Pia Lorenzo , Monte Olga Dal 
Published: March 2023

Abstract
Interpersonal touch is intrinsically reciprocal since it entails a person promoting and another receiving the touch. While several studies have investigated the beneficial effects of receiving an affective touch, the affective experience of caressing another individual remains largely unknown. Here, we investigated the hedonic and autonomic responses (skin conductance and heart rate) of people when they promote an affective touch. We also examined whether interpersonal relationship, gender, and eye contact modulate these responses. As expected, caressing the partner was perceived more pleasant then caressing a stranger, especially if the affective touch occurred together with mutual eye contact. Promoting an affective touch to the partner also resulted in a decrease of both autonomic responses and anxiety levels, suggesting the occurrence of a calming effect. Additionally, these effects were more pronounced in females compared to males, indicating that hedonic and autonomic aspects of affective touch are modulated by social relationships as well as by gender. These findings show for the first time that caressing a beloved one is not only pleasant, but also reduces autonomic responses and anxiety in the person promoting the touch. This might suggest that affective touch has an instrumental role for romantic partners in promoting and reinforcing their affective bonding.
Toward an indoor lighting solution for social jet lag
Authors: Kuchenbecker James , Neitz Alex , Rice Alicia , Casiraghi Leandro , Bussi Ivana , Buhr Ethan , Neitz Maureen , Neitz Jay , Iglesia Horacio de la 
Published: March 2023

Abstract
There is growing interest in developing artificial lighting that stimulates intrinsically photosensitive retinal ganglion cells (ipRGCs) to entrain circadian rhythms to improve mood, sleep, and health. Efforts have focused on stimulating the intrinsic photopigment, melanopsin; however, recently, specialized color vision circuits have been elucidated in the primate retina that transmit blue-yellow cone-opponent signals to ipRGCs. We designed a light that stimulates color-opponent inputs to ipRGCs by temporally alternating short and longer wavelength components that strongly modulate short-wavelength sensitive (S) cones. Two-hour exposure to this S-cone modulating light produced an average circadian phase advance of one hour and twenty minutes in 6 subjects (mean age = 30 years) compared to no phase advance for the subjects after exposure to a 500-lux white light equated for melanopsin effectiveness. These results are promising for developing artificial lighting that is highly effective in controlling circadian rhythms by invisibly modulating cone-opponent circuits.
Cerebrospinal Fluid from Patients after Craniotomy with the Appearance of Interleukin-6 Storm can Activate Microglia to Damage the Hypothalamic Neurons
Authors: Huang Haorun , Liao Xixian , Zhang An , Qiu Binghui , Mei Fen , Liu Fan , Zeng Kai , Yang Chunen , Ma Haidie , Ding Wenjie , Qi Songtao , Bao Yun 
Published: March 2023

Abstract
Introduction: We monitored CSF (cerebrospinal fluid) for Th1/Th2 inflammatory cytokines in a patient with unexplained postoperative disturbance of consciousness after craniotomy and found that the level of IL-6 (Interleukin-6) concentrations was extremely high, meeting the traditional criteria for an inflammatory cytokine storm. Subsequently, the cerebrospinal fluid specimens of several patients were tested, and it was found that IL-6 levels were increased in different degrees after craniotomy. Previous studies have focused more on mild and long-term IL-6 elevation, but less on the effects of this short-term IL-6 inflammatory cytokine storm. Cerebrospinal fluid rich in IL-6 may play a significant role in patients after craniotomy.
Objective: To explore the degree of IL-6 elevation and the incidence of IL-6 inflammatory cytokine storm in patients after craniotomy, as well as the effect of IL-6 elevation on brain. In this study, the levels and clinical manifestations of inflammatory factors in cerebrospinal fluid after craniotomy were statistically classified, and the underlying mechanisms were discussed preliminarily.
Methods: CSF specimens of patients after craniotomy were collected, IL-6 level was measured at 1, 5 and 10 days after operation, and cognitive function was analyzed at 1, 10 and 180 days after surgery. Craniotomy mouse model, cerebrospinal fluid of patients with the appearance of IL-6 storm after craniotomy and IL-6 at the same concentration stimulation model were established. Behavioral tests, fluorescence in situ hybridization (FISH), pathological means, western blot, Elisa (enzyme-linked immune-sorbent assay) were performed for verification.
Results: CSF from patients after craniotomy caused disturbance of consciousness in mice, affected neuronal damage in the hypothalamus, activation of microglia in the hypothalamus, and decreased expression of barrier proteins in the hypothalamus and brain. The large amount of interleukin-6 in CSF after craniotomy was found to be mainly derived from astrocytes. The IL-6 level in CSF after craniotomy correlated inversely with patients’ performance in MoCA test.
Conclusion: High levels of IL-6 in the cerebrospinal fluid derived from astrocytes after craniotomy may lead to disruption of the brain-cerebrospinal fluid barrier, most notably around the hypothalamus, which might result in inflammatory activation of microglia to damage the hypothalamic neurons and impaired cognitive function/more gradual cognitive repairment in patients after craniotomy with the appearance of IL-6 storm.
Assessment of bacterial and viral gut communities in healthy and tumoral colorectal tissue using RNA and DNA deep-sequencing
Authors: Garcia-Serrano Ainhoa , Mukhedkar Dhananjay , Hultin Emilie , Rudsander Ulla , Wettergren Yvonne , Ure Agustín Enrique , Mühr Laila Sara Arroyo , Dillner Joakim 
Published: March 2023

Abstract
Human gut microbiome studies typically focus on 16S RNA analyses and bacterial identification at the genus level. We analyzed bacterial and viral communities in colorectal tissue using both DNA and RNA sequencing and improved taxonomy resolution to species level.
Specimens from 10 colorectal cancer patients and 10 matched control patients were DNA and RNA sequenced using Illumina Novaseq. Following taxonomy classification using Kraken 2, alpha and beta diversities (different metrics) as well as relative and differential abundance were calculated.
There were no viral differences, but P. nesessarius had a highly increased presence in tumors (p=0.001). RNA analyses showed that A. massiliensis had a highly decreased transcription in tumors (p=0.002) while F. nucleatum transcription was highly increased in tumors (p=0.002).
In conclusion, joint assessment of the metagenome (DNA) and the metatranscriptome (RNA) at the species level identifies specific bacterial species as tumor-associated.