bluuebunny/crossref_metadata_2025_split huggingface dataset:
(173) ONCO-TESE DURING ORCHIECTOMY FOR TESTICULAR TUMOR IN PATIENTS WITH AZOOSPERMIA/OLIGOZOOSPERMIA: OUR EXPERIENCE
Authors: Andrea R Serrano , Esau F Pascual , Maria Belen A Bartolomé , Cristina B Ruiz , Carlos T Vázquez , Álvaro Javier Y Alonso , Luis M Piñeiro-Lorenzo 
Published: July 2023

Abstract

Objectives
Patients with testicular cancer are at increased risk of infertility or semen quality abnormalities. Due to the high cure rates of testicular tumors (especially germ cell tumors), fertility protection is becoming increasingly important. For this reason it is mandatory to offer sperm cryopreservation prior to treatment. In patients with oligo/azoospermia prior to orchiectomy, other cryopreservation options can be considered. The aim of this paper is to analyze the results of a cohort of patients undergoing Onco-testicular Sperm Extraction (Onco-TESE).

Methods
A retrospective review of patients undergoing orchiectomy for testicular tumor in the last 5 years was performed. Those in whom sperm cryopreservation was impossible were offered to undergo, in the same procedure, a Sperm retrieval testicular biopsy (Onco-TESE), from the contralateral testicle or from the same testicle (if this was possible or necessary).

Results
A total of 108 patients underwent radical orchiectomy between 2016 and 2022 in our center. Of these, 67.5% of patients were considered suitable for seminal cryopreservation (due to age, future genomic desires). Of all of them, 11/73 (15.1%) presented azoospermia or severe oligozoospermia. Six patients underwent simultaneous radical orchiectomy and Onco-TESE. Another orchiectomized patient underwent contralateral testicular biopsy after being diagnosed with azoospermia in the cryopreservation attempt prior to chemotherapy. The mean age was 35.7 years. One patient had a diagnosis of Klinefelter's disease (karyotype 47XXY), and another had a childhood history of orchiectomy of unknown cause. Sperm retrieval was achieved in 3 patients (they did not present any previous genetic alteration). Pathological anatomy showed seminoma in 5/7 patients, TGNS in 1/7 and benign Leydig cell tumor in the last one.

Conclusions
Seminal cryopreservation should always be performed prior to radical orchiectomy because in case it is not valid, the performance of Onco-TESE can be resorted to as an attempt of Sperm retrieval.

Conflicts of Interest
None of the authors have any conflict of interest.
(12) CONCEPTUALIZING FEMININITY THROUGH ANALYSIS OF PSYCHOSOCIAL DIMENSIONS OF MENSTRUATION IN INDIGENOUS PAKISTANI CONTEXT
Authors: Dr. Ahmad Bilal , Sehba Sadiq 
Published: July 2023

Abstract

Objectives
Menstruation has been an integral part of traditional woman’s body. In modern times, women derive meanings to form and shape their feminine identity in context of menstrual discourse. But the experiences of South Asian especially Pakistani women are different from the modern Western women. Therefore, the present study was conducted to conceptualize the femininity by analyzing the menstruation discourse of Pakistani women.

Methods
A total of 11 women of reproductive age living in South Punjab province of Pakistan were interviewed. The open ended interview format was employed for gathering detailed discourses regarding menstrual experiences. The qualitative thematic analysis technique was used to extract themes related to menstruation experiences of women.

Results
Several myths and themes were extracted from the thematic analysis. The myths and themes were categorized as; (i) Initial Menstrual Experiences (ii) Obscure Menstruation Terminologies used by women (iii) Non Scientific Cultural Experiences related to Menstruation (iv) Personal Hygiene during Menstruation (v) Use and Availability of Sanitary Products during Menstruation (vi) Use of Medication during Menstruation (vii) Interpersonal Interaction during Menstruation. Each category had its specific myths and subthemes related to menstruation experiences.

Conclusions
The study concluded that menstrual experience comes as a trauma and is considered a taboo to be discussed. It is suggested that development and gender specific sex education should be introduced at educational institutions to make the women desensitize regarding their menstrual experiences. The male members of the society should also get education about menstruation so that they may treat women more empathically. Further, the public places should have availability of sanitary products and the women should be given 1-2 monthly leaves at their workplaces.

Conflicts of Interest
The authors declare no conflict of interest.
(142) THE INFLUENCE OF SEXUAL ACTIVITY ON SLEEP: A DIARY STUDY
Authors: Carlotta F Oesterling , Dr. Charmaine Borg , Elina Juhola , Dr. Marike Lancel 
Published: July 2023

Abstract

Objectives
As previous literature has shown that sexual activity affects sleep but has yielded discrepant findings, a cross-sectional and a longitudinal (diary) study have been conducted to clarify to what extent the type of sexual activity (i.e., sexual intercourse versus masturbation) impacts the effect of sexual activity on sleep, whether having an orgasm is necessary for such effects to become apparent, and lastly, whether the effect of sexual activity on sleep differs between men and women.

Methods
The effect of sexual activity on sleep is investigated by combining a cross-sectional survey based on previous work by Pallesen et al. (2020) and Lastella et al. (2019) with a longitudinal design in the form of a diary study. 256 male and female participants, mainly students, completed a pre-test set of questionnaires and thereafter a diary during 14 consecutive days. The cross-sectional study was analyzed using ANCOVA and follow-up analyses of weighted means (separately for men and women) with 95% confidence intervals. Accounting for the nested structure of the data, the diary data was analysed by building two separate Multilevel Linear Models. The analyses included 2076 cases at level one, which were nested within 159 participants at level two.

Results
The cross-sectional study demonstrated that both men and women perceive sexual intercourse and masturbation with orgasm to improve sleep latency and sleep quality, while sexual activity without orgasm exerts negative effects on these sleep parameters, most strongly in men. The longitudinal data analyses revealed that only sexual intercourse with orgasm significantly shortens sleep latency and increases sleep quality and to a similar extent in men and women.

Conclusions
The present studies confirm and significantly substantiate findings indicating that sexual activity and intimacy may improve sleep and overall wellbeing in both men and women and serve as a directive for future research.

Conflicts of Interest
There are no conflicts of interests to be declared.
(317) THE UNIQUENESS OF NONVERBAL EXPRESSIONS IN RELATIONSHIPS AMONG WOMEN WITH SEXUAL DYSFUNCTION
Authors: Ronit Basher Lazar , Dr. Einat Shuper Engelhard , Dr. Anna Petruseva , Prof. Ilan Gruenwald , Dr. Arik Shechter 
Published: July 2023

Abstract

Objectives
Recently, studies emphasized the importance of “embodiment knowledge” (EK) - the lifetime experience in relationships as internalized, in understanding women’s sexual function. While studies found a high prevalence of insecure attachment patterns among women with sexual dysfunctions (SD), and other studies revealed movement characteristics that were unique to insecure attachment, we aimed to examine nonverbal expressions of EK as expressed in interpersonal communication among women with SD. We hypothesized EK will be expressed as a diminished capacity for playfulness and exploration in movement among women with SD.

Methods
We included women with (n=28) and without (n=14) SD. Female Sexual Function Index and Experiences in Close Relationships questionnaires were completed. EK, as expressed via nonverbal behavior was examined during a Mirror Game (MG) and analyzed utilizing the Mirroring Game Scale (MGS). Results were analyzed using the Shapiro wilk test, T-TEST or Mann Whitney and Pearson correlation for evaluating differences and correlations between SD and EK.

Results
A significant difference was found between the groups (p&lt;0.05), in the competitiveness item in MGS, i.e women without SD demonstrated higher competitiveness in their nonverbal communication during the MG compared to women with SD. A further analysis found a significant correlation between greater sexual arousal (r=0.403; p&lt;0.01) & more orgasms (r=0.368; p&lt;0.05) and higher levels of competitiveness in their movement. In addition, less pain during sex correlated with a higher pleasure (r=0.387; p&lt;0.05) & exploration in movement (r=0.327; p&lt;0.01) items; women who experienced less pain during sex expressed more pleasure and exploration during the MG. In this category the groups also differed significantly in movement flow (p&lt;0.05).

Conclusions
This study expands our of knowledge on women's SD and embodiment by empirically supporting the uniqueness of nonverbal expressions in relationships among women with SD. These novel findings contribute to the development of additional modes of diagnosis and treatment of female SD.

Conflicts of Interest
No conflict of interest.
(224) CLIMACTERIC SYNDROME: LESBIANS VERSUS HETEROSEXUAL WOMEN
Authors: Pavel Turčan , Dr. Pavel Pokorny , Dr. Jana Kvintova , Dr. Peter Kepic , Eva Sedlata Juraskova 
Published: July 2023

Abstract

Objectives
Climacterium is a physiological period in a woman’s life, reached by both heterosexual women and lesbians. There are several difficulties associated with the transition to menopause, which is referred to as climacteric syndrome (CS). There are differences between women as to the perception of climacteric difficulties. In our study, we focus on the differences in the perception of CS between heterosexual women and lesbians.

Methods
We assessed a group of 48 heterosexual women and 42 lesbians using a self-assessment scale of a modified version of the Kupperman index (KI), which focuses not only on the so-called acute (vegetative) but also in part on the subacute (organic) symptomatology of CS. We used the Mann-Whitney U-test to evaluate the results of individual symptoms and we chose Fisher’s exact test to compare the percentages of women according to the severity of CS.

Results
Similar results were found in most of the monitored parameters, regardless of sexual orientation. The most important finding of the study is that lesbians tolerate menopausal difficulties statistically significantly better and have a lower incidence of pain during sexual intercourse than heterosexual women. Heterosexual women in whom no form of CS was present according to KI accounted for 37.5% compared with 57.1% of women in the lesbian group, mild CS was observed in 18.8 of HW compared with 31% of LW, moderate severe CS in 43.8% of HW vs. 11.9% of LW. We did not observe severe CS in either group.

Conclusions
Similar results were found in most of the monitored parameters in both groups. Among other things, psychological factors, such as better communication and mutual understanding of lesbian partners, may contribute to better tolerance. The statistically significantly lower incidence of painful coitus is certainly influenced by the fact that lesbians have a wider range of non-penetrative sexual practices than heterosexual women.

Conflicts of Interest
We have no confilct of interest.
Discovery of five Green pea galaxies with double-peaked narrow [O iii] lines
Authors: Lin Ruqiu , Zheng Zhen-Ya , Wang Jun-Xian , Yuan Fang-Ting , Rhoads James E , Malhotra Sangeeta , An Tao , Jiang Chunyan , Zhu Shuairu , Rahna P T , Ji Xiang , Singha Mainak 
Published: July 2023

ABSTRACT
Although double-peaked narrow emission-line galaxies have been studied extensively in the past years, only a few are reported with the Green pea (GP) galaxies. Here we present our discovery of five GP galaxies with double-peaked narrow [O iii] emission lines, referred to as DPGPs, selected from the LAMOST and SDSS spectroscopic surveys. We find that these five DPGPs have blueshifted narrow components more prominent than the redshifted components, with velocity offsets of [O iii]λ5007Å ranging from 306 to 518 $\rm km\, s^{-1}$, and full widths at half maximums of individual components ranging from 263 to 441 $\rm km\, s^{-1}$. By analysing the spectra and the spectral energy distributions (SEDs), we find that they have larger metallicities and stellar masses compared with other GPs. The H α line width, emission-line diagnostic, mid-infrared colour, radio emission, and SED fitting provide evidence of the AGN activities in these DPGPs. They have the same spectral properties of type 2 quasars. Furthermore, we discuss the possible nature of the double-peaked narrow emission-line profiles of these DPGPs and find that they are more likely to be dual active galactic nuclei (AGNs). These DPGP galaxies are ideal laboratories for exploring the growth mode of AGNs in the extremely luminous emission-line galaxies, the co-evolution between AGNs and host galaxies, and the evolution of high-redshift galaxies in the early Universe.
Varieties of Grounding Skepticism
Authors: Kovacs David Mark 
Published: July 2023

Abstract:Skepticism about grounding is the view that ground-theoretic concepts shouldn’t be used in meta­physical theorizing. Possible reasons for adopting this attitude are numerous: perhaps grounding is unintelligible; or perhaps it’s never instantiated; or perhaps it’s just too heterogeneous to be theor­­­­­etically useful. Unfortunately, as currently pursued the debate between grounding enthusiasts and skeptics is insufficiently structured. This paper’s purpose is to impose a measure of conceptual rigor on the debate by offering an opinionated taxonomy of views with a reasonable claim to being “skeptical.” I argue that carving up logical space into pro- and anti-grounding views isn’t especially helpful; rather, we should recognize various degrees of ground-theoretic involvement depending on how inflationary our understanding of the theoretical term ‘ground’ is.
Werner syndrome associated with poorly differentiated thyroid carcinoma and systemic sclerosis-like skin manifestations: A case report
Authors: Sugawara Eri , Shibata Yuhei , Katsumata Kazuaki 
Published: July 2023

ABSTRACT
Werner syndrome (WS) is an autosomal recessive disorder characterised by premature ageing. WS patients often experience scleroderma-like manifestation including skin sclerosis and skin ulcer, making it difficult to differentiate WS from systemic sclerosis (SSc). Moreover, there is a high incidence of malignancy and arteriosclerosis-related disease in WS patients. We herein describe a 36-year-old woman with WS who had poorly differentiated thyroid carcinoma, one of the rare phenotypes of thyroid tumour. This case suggested the importance to distinguish WS from SSc and early diagnosis of malignancy.
Evaluating hematologic parameters in newly diagnosed and recurrent glioblastoma: Prognostic utility and clinical trial implications of myelosuppression
Authors: Deng Davy , Hammoudeh Lubna , Youssef Gilbert , Chen Yu-Hui , Shin Kee-Young , Lim-Fat Mary Jane , McFaline-Figueroa Jose Ricardo , Chukwueke Ugonma N , Tanguturi Shyam , Reardon David A , Lee Eudocia Q , Nayak Lakshmi , Bi Wenya Linda , Arnaout Omar , Ligon Keith L , Wen Patrick Y , Rahman Rifaquat 
Published: July 2023

Abstract

Background
Glioblastoma (GBM) patients are treated with radiation therapy, chemotherapy, and corticosteroids, which can cause myelosuppression. To understand the relative prognostic utility of blood-based biomarkers in GBM and its implications for clinical trial design, we examined the incidence, predictors, and prognostic value of lymphopenia, neutrophil-to-lymphocyte ratio (NLR), and platelet count during chemoradiation (CRT) and recurrence.

Methods
This cohort study included 764 newly diagnosed glioblastoma patients treated from 2005 to 2019 with blood counts prior to surgery, within 6 weeks of CRT, and at first recurrence available for automatic extraction from the medical record. Logistic regression was used to evaluate exposures and Kaplan–Meier was used to evaluate outcomes.

Results
Among the cohort, median age was 60.3 years; 87% had Karnofsky performance status ≥ 70, 37.5% had gross total resection, and 90% received temozolomide (TMZ). During CRT, 37.8% (248/656) of patients developed grade 3 or higher lymphopenia. On multivariable analysis (MVA), high NLR during CRT remained an independent predictor for inferior survival (Adjusted Hazard Ratio [AHR] = 1.57, 95% CI = 1.14–2.15) and shorter progression-free survival (AHR = 1.42, 95% CI = 1.05–1.90). Steroid use was associated with lymphopenia (OR = 2.66,1.20–6.00) and high NLR (OR = 3.54,2.08–6.11). Female sex was associated with lymphopenia (OR = 2.33,1.03–5.33). At first recurrence, 28% of patients exhibited grade 3 or higher lymphopenia. High NLR at recurrence was associated with worse subsequent survival on MVA (AHR = 1.69, 95% CI = 1.25–2.27).

Conclusions
High NLR is associated with worse outcomes in newly diagnosed and recurrent glioblastoma. Appropriate eligibility criteria and accounting and reporting of blood-based biomarkers are important in the design and interpretation of newly diagnosed and recurrent glioblastoma trials.
Perceptions of COVID-19 vaccine side effects by political affiliation
Authors: Farabee David , Hawken Angela 
Published: July 2023

Abstract

Background
We sought to assess the extent to which subjective experiences of COVID-19 vaccine side effects among US adults are associated with political party identification.

Methods
An online survey was conducted of a national sample of US adults (N = 1259) identifying as either Republican or Democrat.

Results
There was no significant difference by party identification in the perceived severity of vaccination side effects; however, Republicans were significantly less likely to recommend the vaccine to others in light of their experience (OR = 0.40; 95% CI, 0.31–0.51; P &lt; 0.001). Republicans also reported having a larger share of COVID-19-vaccinated friends and family who experienced notable side effects (OR = 1.31; 95% CI, 1.02–1.68; P &lt; 0.05). There was a positive association between respondents’ perceived side-effect severity and the proportion of peers who also reported notable side effects (r = 0.43; P &lt; 0.001).

Conclusion
Subjective appraisals of the vaccinated may affect broader vaccine acceptability.
Assessment of digital perfusion as a surrogate outcome in Raynaud’s phenomenon clinical trials
Authors: Guigui Alicia , Liaigre Léa , Manceau Marc , Gaget Olivier , Cracowski Jean-Luc , Blaise Sophie , Khouri Charles , Roustit Matthieu 
Published: July 2023

Abstract

Objectives
Measurement of digital perfusion, sometimes coupled with a cold challenge, has been widely used as an objective outcome in trials evaluating drug therapies in RP, in addition to patient-reported outcomes or to establish the proof-of-concept in preliminary studies. However, whether digital perfusion is a valid surrogate for clinical outcomes in RP trials has never been explored. The principal aim of this study was to evaluate the potential surrogacy of digital perfusion, by combining individual-level and trial-level data.

Methods
We used individual data from a series of n-of-1 trials, and trial data from a network meta-analysis. We estimated individual-level surrogacy through coefficients of determination between digital perfusion and clinical outcomes (R2ind). We further calculated the coefficients of determination between treatment effect on the clinical outcomes and on digital perfusion, at the individual level (R2TEind) and at the trial level (R2trial), using non-weighted linear regression, with their 95% CI calculated through bootstrapping.

Results
Results from 33 patients and 24 trials were included in the final analysis. At the individual level, there was no correlation between digital perfusion and clinical outcomes at rest and in response to various cooling tests (the highest R2ind was 0.03 [−0.07, 0.09]), and R2TEind was also very low 0.07 (0, 0.29). At the trial level, the highest value of R2trial was 0.1 (0, 0.477).

Conclusions
Digital perfusion, at rest or in response to a cold challenge, and whatever the method used, does not fulfil the criteria of a valid surrogate for existing patient-reported outcomes in RP trials.
Adapting a transdiagnostic digital mental health intervention for use among immigrant and refugee youth in Seattle: a human-centered design approach
Authors: Fabian Katrin E , Foster Katherine T , Chwastiak Lydia , Turner Morgan , Wagenaar Bradley H 
Published: July 2023

Abstract
Digital mental health interventions show promise in addressing mental health needs, especially among youth and marginalized communities. This study adapted the World Health Organization -developed STARS (Sustainable Technology for Adolescents to Reduce Stress) digital mental health intervention for use among youth and young adults aged 14–25 from immigrant and refugee communities in Seattle, Washington. Human-centered design methods centered around qualitative semi-structured interviews were used to contextually and culturally adapt the intervention and prioritize the needs and preferences of the intended end user. Intervention prototypes were modified and then presented to the target groups in iterative cycles until saturation was achieved. Qualitative interviews occurred in three iterations of five participants each. Modifications were documented according to the Framework for Reporting Adaptations and Modifications—Expanded (FRAME) implementation science framework. Modifications aligned with the FRAME process elements: (a) tailoring/refining, which included adapting language to less resemble digital phishing scams; (b) changes in packaging or materials, which included naming the chatbot and adopting a corresponding avatar; (c) adding/removing, which included changing existing emojis and adding additional media types including graphics interchange format images, pictures, and voice memos; (d) shortening/condensing, which included shortening the length of individual text sections as well as deleting redundant language; (e) lengthening/extending, which included allowing the user to choose to receive content catered to teenagers or to adults; and (f) loosening structure, including giving users options to skip parts of modules or to engage with additional material. The modified STARS intervention shows promise for engagement with immigrant and refugee youth in Seattle and can be examined for clinical effectiveness. Adaptations increased the relevance of content to the intended end user, expanded options for personalization and customization of the user experience, and utilized language that was age appropriate, engaging, and did not invoke feelings of stigma or distrust. Adaptations of digital mental health interventions should focus on modifications that maximize acceptability and appropriateness to intended audiences.