bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fractional discrete Temimi–Ansari method with singular and nonsingular operators: applications to electrical circuits
Authors: Fareed Aisha F. , Elbarawy Menna T. M. , Semary Mourad S. 
Published: January 2023

AbstractThe goal of this article is to present a recently developed numerical approach for solving fractional stochastic differential equations with a singular Caputo kernel and a nonsingular Caputo–Fabrizio and Atangana–Baleanu (ABC) kernel. The proposed method is based on the discrete Temimi–Ansari method, which is combined with three different numerical schemes that are appropriate for the new fractional derivative operators. The proposed technique is used to investigate the effects of Gaussian white-noise and Gaussian colored-noise perturbations on the potential source and resistance in fractional stochastic electrical circuits. The proposed method’s robustness and efficiency were demonstrated by comparing its results to those of the stochastic Runge–Kutta method (SRK). The valuable point in this article is that the resulting numerical scheme is able to combine two powerful methods that can be extended into more complex stochastic models. The comparison of different fractional derivatives using Mathematica 12 software has been obtained and the simulation results demonstrate the merit of the contributed method.
Deep learning approach to security enforcement in cloud workflow orchestration
Authors: El-Kassabi Hadeel T. , Serhani Mohamed Adel , Masud Mohammad M. , Shuaib Khaled , Khalil Khaled 
Published: January 2023

AbstractSupporting security and data privacy in cloud workflows has attracted significant research attention. For example, private patients’ data managed by a workflow deployed on the cloud need to be protected, and communication of such data across multiple stakeholders should also be secured. In general, security threats in cloud environments have been studied extensively. Such threats include data breaches, data loss, denial of service, service rejection, and malicious insiders generated from issues such as multi-tenancy, loss of control over data and trust. Supporting the security of a cloud workflow deployed and executed over a dynamic environment, across different platforms, involving different stakeholders, and dynamic data is a difficult task and is the sole responsibility of cloud providers. Therefore, in this paper, we propose an architecture and a formal model for security enforcement in cloud workflow orchestration. The proposed architecture emphasizes monitoring cloud resources, workflow tasks, and the data to detect and predict anomalies in cloud workflow orchestration using a multi-modal approach that combines deep learning, one class classification, and clustering. It also features an adaptation scheme to cope with anomalies and mitigate their effect on the workflow cloud performance. Our prediction model captures unsupervised static and dynamic features as well as reduces the data dimensionality, which leads to better characterization of various cloud workflow tasks, and thus provides better prediction of potential attacks. We conduct a set of experiments to evaluate the proposed anomaly detection, prediction, and adaptation schemes using a real COVID-19 dataset of patient health records. The results of the training and prediction experiments show high anomaly prediction accuracy in terms of precision, recall, and F1 scores. Other experimental results maintained a high execution performance of the cloud workflow after applying adaptation strategy to respond to some detected anomalies. The experiments demonstrate how the proposed architecture prevents unnecessary wastage of resources due to anomaly detection and prediction.
[68Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [18F]-FDG PET MRI/CT: a meta-analysis
Authors: Wang Yawen , Luo Wenhao , Li Ye 
Published: January 2023

Abstract
Objectives
To compare the detection rates of [68Ga]Ga-FAPI-04 PET MRI/CT vs. [18F]-FDG PET MRI/CT in gastric cancer.

Methods
An extensive librarian-led literature search of PubMed, Embase, Web of Science, the Cochrane Central Library, and ClinicalTrials.gov was performed. The primary outcomes were sensitivity in patient-based evaluations, detection of lymph node metastases, and peritoneal involvement.

Results
Five studies, including 148 participants, were analyzed. [68Ga]Ga-FAPI-04 PET MRI/CT has a comparatively high sensitivity in patient-based evaluations compared with [18F]-FDG PET MRI/CT (risk difference = 0.16, 95% CI 0.09–0.22, P < 0.00001). The [68Ga]Ga-FAPI-04 PET MRI/CT group has a comparatively higher sensitivity in detecting lymph node metastases (RR = 0.15, 95% CI 0.01–0.29, P = 0.04), peritoneal involvement (RR = 0.55, 95% CI 0.38–0.72, P < 0.00001) in gastric cancer than [18F]-FDG PET MRI/CT group.

Conclusions
This systematic review confirmed the advantage of [68Ga]Ga-FAPI-04 PET MRI/CT in gastric cancer. [68Ga]Ga-FAPI-04 PET MRI/CT was superior to [18F]-FDG PET MRI/CT in detecting the primary tumor, lymph node metastases, and peritoneal metastases. More studies are needed for the sensitivity and specificity of [68Ga]Ga-FAPI-04 PET MRI/CT in different pathological types of gastric cancer.
Advances of mRNA vaccine in tumor: a maze of opportunities and challenges
Authors: Yuan Yuan , Gao Fan , Chang Ying , Zhao Qiu , He Xingxing 
Published: January 2023

AbstractHigh-frequency mutations in tumor genomes could be exploited as an asset for developing tumor vaccines. In recent years, with the tremendous breakthrough in genomics, intelligence algorithm, and in-depth insight of tumor immunology, it has become possible to rapidly target genomic alterations in tumor cell and rationally select vaccine targets. Among a variety of candidate vaccine platforms, the early application of mRNA was limited by instability low efficiency and excessive immunogenicity until the successful development of mRNA vaccines against SARS-COV-2 broken of technical bottleneck in vaccine preparation, allowing tumor mRNA vaccines to be prepared rapidly in an economical way with good performance of stability and efficiency. In this review, we systematically summarized the classification and characteristics of tumor antigens, the general process and methods for screening neoantigens, the strategies of vaccine preparations and advances in clinical trials, as well as presented the main challenges in the current mRNA tumor vaccine development.
Digital technology virtual restoration of the colours and textures of polychrome Bodhidharma statue from the Lingyan Temple, Shandong, China
Authors: Tong Yongdong , Cai Youzhen , Nevin Austin , Ma Qinglin 
Published: January 2023

Abstract
This work proposes the virtual restoration of the Bodhidharma polychrome sculpture from the Lingyan Temple in China. Based on scientific analyses and simulation experiments, exterior colours and textures were virtually restored by combining 3D scanning and multi-view 3D reconstruction. At the same time, an efficient cultural relics high-fidelity information 3D modelling method was proposed. Colours and textures are essential for polychrome cultural relics, reflecting the historical appearance and technology. Due to long periods of natural ageing and the destruction of environmental factors, the colours and textures of polychrome sculptures are often altered or radically changed, making it difficult for people to appreciate the initial appearance. With the rapid development of digital technology and high-fidelity 3D modelling, virtual reality technology allows us to restore the appearance of cultural relics. This study expands the dimension of cultural relics exhibition, provides new perspectives for archaeology, art history and cultural heritage research, and provides a reference for the virtual restoration and digitalised archive of other cultural relics.
Tumor size measurements of pancreatic cancer with neoadjuvant therapy based on RECIST guidelines: is MRI as effective as CT?
Authors: Yang Panpan , Mao Kuanzheng , Gao Yisha , Wang Zhen , Wang Jun , Chen Yufei , Ma Chao , Bian Yun , Shao Chengwei , Lu Jianping 
Published: January 2023

Abstract
Objectives
To compare tumor size measurements using CT and MRI in pancreatic cancer (PC) patients with neoadjuvant therapy (NAT).

Methods
This study included 125 histologically confirmed PC patients who underwent NAT. The tumor sizes from CT and MRI before and after NAT were compared by using Bland–Altman analyses and intraclass correlation coefficients (ICCs). Variations in tumor size estimates between MRI and CT in relationship to different factors, including NAT methods (chemotherapy, chemoradiotherapy), tumor locations (head/neck, body/tail), tumor regression grade (TRG) levels (0–2, 3), N stages (N0, N1/N2) and tumor resection margin status (R0, R1), were further analysed. The McNemar test was used to compare the efficacy of NAT evaluations based on the CT and MRI measurements according to RECIST 1.1 criteria.

Results
There was no significant difference between the median tumor sizes from CT and MRI before and after NAT (P = 0.44 and 0.39, respectively). There was excellent agreement in tumor size between MRI and CT, with mean size differences and limits of agreement (LOAs) of 1.5 [-9.6 to 12.7] mm and 0.9 [-12.6 to 14.5] mm before NAT (ICC, 0.93) and after NAT (ICC, 0.91), respectively. For all the investigated factors, there was good or excellent correlation (ICC, 0.76 to 0.95) for tumor sizes between CT and MRI. There was no significant difference in the efficacy evaluation of NAT between CT and MRI measurements (P = 1.0).

Conclusion
MRI and CT have similar performance in assessing PC tumor size before and after NAT.
Fertility intention among married women in Ethiopia: a multilevel analysis of Ethiopian demographic health survey 2016
Authors: Tsegaye Negash Berhan 
Published: January 2023

AbstractBackgroundFertility intention is the central aspect of countries which determine their population demography. Therefore, proportion and factors associated with fertility intention should be studied at different level of community for designing of appropriate policies, strategies, and programs. Despite its importance, information is scarce about proportion and predictors of fertility intention among women of reproductive age in Ethiopia, in 2016.MethodsA secondary data analysis was done on 2016 Ethiopian Demographic and Health Survey/EDHS/ in this study. A total of 1423 fecund, married, and sexually active women were included this study. Multilevel mixed-effect logistic regression model was done to show association between fertility desire and explanatory variables. Adjusted Odds Ratio with 95% Confidence Interval (CI) was computed to assess the strength and significance of association.ResultsPrevalence of fertility intention was 63.5% (95%CI:62.2%,64.8%) in Ethiopia, in 2016. The response rate of this study was 100%. The odd of fertility desire was higher among women of age 20-34 years (AOR=2.5,95%CI:1.5,4.0), women of age 35-49 years (AOR= 9,95%CI:12.2,45.4), Muslim followers (AOR=5.4,95%CI:3.6,7.9), other religions followers (AOR= 1.8,95%CI:1.2,3.0), women who did not want to use modern contraceptive (AOR=3.1,95%CI:2.2,4.3). However, the likelihood of fertility intention was low among women who owned mobile phone (AOR=0.6,95%CI:0.4,0.87), and women with more than one partner (AOR=0.5,95%CI:0.41,0.8). At the community level factors like: Community education status (AOR= 1.67,95%CI:1.26,2.2) and region were factors strongly linked to fertility intention.ConclusionsIn this study, prevalence of fertility desire was higher compared to other countries. Participants age, religion, intention to use modern contraceptive, own mobile, and having multiple partners were individual factors associated with fertility preference. Furthermore, educational status and region were community factor associated significantly with intention of fertility. Hence, expansion of mobile networking and family planning messages through mobile. Furthermore, religious teaching should be enhanced to control family size among followers. Finally, the Ethiopian government should also work strongly to improve community education.
Reversible cardiomyopathy in a patient with chronic myelomonocytic leukemia treated with decitabine/cedazuridine: a case report
Authors: Sheel Ankur , Bae Junu , Asada Ashlee , Otterson Gregory A. , Baliga Ragavendra R. , Koenig Kristin L. 
Published: January 2023

Abstract
Background
Hypomethylating agents (HMAs) have shown efficacy in the treatment of hematological malignancies and are indicated for the treatment of chronic myelomonocytic leukemia (CMML). While the HMA decitabine, in its intravenous formulation, has been used since 2006 for the treatment of CMML, use of its oral formulation has been limited by poor bioavailability due to first-pass metabolism by the enzyme cytidine deaminase. The dose of intravenous decitabine is limited by toxicities such as cardiomyopathy and heart failure. Therefore, cedazuridine was developed as an inhibitor of cytidine deaminase. Cedazuridine decreases the first-pass metabolism of oral decitabine allowing therapeutic levels to be achieved at lower doses, and thus, the novel oral combination of cedazuridine with decitabine was developed. While cardiomyopathy and heart failure are well-established adverse effects associated with intravenous decitabine alone, there to our knowledge there have been no documented incidences of reversible cardiomyopathy in the literature or in patients who participated in the phase 2 and phase 3 clinical trials of oral decitabine-cedazuridine.

Case
This case study presents an 85 year-old Caucasian female with CMML who developed cardiomyopathy and heart failure with reduced ejection fraction after completing 5 cycles of therapy with decitabine/cedazuridine. Furthermore, her symptoms and cardiac function recovered upon discontinuation of the drug.

Conclusions
We present an occurrence of reversible cardiomyopathy in a patient who completed 5 cycles of decitabine/cedazuridine, an oral combination therapy developed to enhance oral bioavailability of decitabine thereby limiting its adverse effects. As the decitabine/cedazuridine combination therapy rises in popularity due to its convenient oral formulation, more trials are needed to understand the prevalence of cardiomyopathy with this drug and to discover preventative strategies for cardiotoxic effects.
Universal HIV testing and the impact of late diagnosis on disease stage among adults in urban Ethiopia
Authors: Getaneh Yimam , Ayalew Jemal , He Qianxin , Tayachew Adamu , Rashid Abdur , Kassa Desta , Leulseged Sileshi , Liao Lingjie , Yi Feng , Shao Yiming 
Published: January 2023

Abstract
Background
Treatment as prevention evolved into the universal HIV test-and-treat (UTT) strategy, which entails testing to the general population and treatment to every people living with HIV. We investigated universal testing (UT) performance and its determinants in urban Ethiopia and explore magnitude of late diagnosis and its impact on disease stages.

Method
We used data from the Ethiopia Population Based HIV Impact assessment (EPHIA), conducted in 2017/2018 which was a cross-sectional and household-based study. For current analysis, we considered self-report first diagnosis to estimate universal testing irrespective of their serostatus and also consider HIV LAg avidity vs viral load vs plasma antiretroviral drug level algorithm to categorize the late diagnosis. We finally evaluate disease stages using CD4 count and viral load. A 2-level multilevel mixed-effect logistic regression model was employed. The effects of individual-level predictors were quantified by the estimates from the fixed-effect part of the model with p-value < 0.05.

Result
Data were collected from 18,926 adults among those 29.4% of people living in Urban Ethiopia were never tested for HIV. Never tested females was 26.4% (95% CI = 25.3; 27.5). Never tested among divorced and widowed were 19.4% (95% CI: 17.3; 21.8) and 28.3% (95% CI: 24.6; 32.2), respectively. Never tested among elderly and youth were high (28.3% among 45–54 years old) to (41.2% among 55–64 years old) to 47.8% among 15–24 years old. Overall, late HIV diagnosis among adults in urban Ethiopia was 25.9% (95% CI: 21.7, 30.2). Late diagnosis varies by region ranged from 38.1% in the Gambella to 5.8% in Benishangul Gumuz. Advanced immune suppression (CD4 count < 350 cells/µl) among newly diagnosed long-term infection were significantly higher compared to those who were recently infected which accounted 47.8% (95%CI = 33.2–52.1) and 30.9% (95%CI = 21.3–32.2), respectively. Moreover, Viral load suppression were significantly lower among those who were late diagnosed 26.1% (95%CI = 13.6–33.8) compared to those of newly infected 89.6% (95%CI = 76.2; 93.4).

Conclusion
With the aim of UT for high risk and priority population, the low rate of HIV testing among widowed, elderly, young adolescent and women in urban Ethiopia calls for enhanced HIV testing. Moreover, the low HIV testing and high late diagnosis among the high-burden regions calls for region-specific intervention. Advanced disease stages as a result of the high proportion of late diagnosis may impact on fueling community transmission and hinder treatment outcome among PLHIV.
Association between antipsychotic medication and clinically relevant weight change: meta-analysis
Authors: Campforts Bea , Drukker Marjan , Crins Joost , van Amelsvoort Therese , Bak Maarten 
Published: January 2023

Background
Previous meta-analyses have shown that almost all antipsychotics are associated with weight gain. However, mean weight gain is not informative about clinically relevant weight gain or weight loss.

Aims
To provide further insight into the more severe body weight changes associated with antipsychotic use, we assessed the proportion of patients with clinically relevant weight gain (CRWG) and clinically relevant weight loss (CRWL), defined as ≥7% weight gain and ≥7% weight loss.

Method
We searched PubMed, Embase and PsycInfo for randomised controlled trials of antipsychotics that reported CRWG and CRWL in study populations aged 15 years or older. We conducted meta-analyses stratified by antipsychotic and study duration using a random-effects model. We performed meta-regression analyses to assess antipsychotic-naive status and psychiatric diagnosis as modifiers for CRWG. PROSPERO: CRD42020204734.

Results
We included 202 articles (201 studies). Almost all included antipsychotics were associated with CRWG. For CRWL, available data were too limited to draw firm conclusions. For some antipsychotics, CRWG was more pronounced in individuals who were antipsychotic-naive than in individuals switching to another antipsychotic. Moreover, a longer duration of antipsychotic use was associated with more CRWG, but not CRWL. For some antipsychotics, CRWG was higher in people diagnosed with schizophrenia, but this was inconsistent.

Conclusions
Switching antipsychotic medication is associated with both weight gain and weight loss, but the level of CRWG is higher than CRWL in antipsychotic-switch studies. CRWG was more pronounced in antipsychotic-naive patients, highlighting their vulnerability to weight gain. The impact of diagnosis on CRWG remains inconclusive.
Health-risk behaviours among people with severe mental ill health: understanding modifiable risk in the Closing the Gap Health Study
Authors: Peckham Emily , Lorimer Ben , Spanakis Panagiotis , Heron Paul , Crosland Suzanne , Walker Lauren , Gilbody Simon 
Published: January 2023

BackgroundPeople with severe mental ill health (SMI) experience some of the largest health inequalities of any sector within society. For these inequalities to be reduced, an understanding of the behavioural determinants of health in this population is needed.AimsUtilising data from the Closing the Gap Health Study, we aimed to assess the extent to which people with SMI report health-risk factors and behaviours, their interest in modifying them, and the factors associated with being motivated to modify these behaviours.MethodAdult (≥18 years old) participants were recruited via primary and secondary care in the English National Health Service. To be eligible, participants needed to have a documented diagnosis of schizophrenia, psychotic disorders or bipolar disorder. Data were collected by survey on demographics, general physical health, diet, physical activity, alcohol, smoking and body mass index.ResultsBetween April 2016 and March 2020, n = 9914 participants were recruited. Among people with SMI, high rates of obesity (37.5%), infrequent physical activity (62.0%), not meeting current guidelines (≥5) for the consumption of fruit and vegetables (85.0%) and smoking (42.2%) were observed. However, most participants were motivated to reduce health-risk behaviours. Perceiving the importance of health-promoting behaviours, being of poorer general health and being female were significantly associated with being motivated to modify health-risk behaviours.ConclusionsDespite experiencing poor physical and mental health outcomes compared with the general population, and contrary to popular misconceptions, people with SMI perceive health as important and are motivated to make behavioural changes to improve health.
Impact of adverse childhood experiences on educational achievements in young people at clinical high risk of developing psychosis
Authors: Tognin Stefania , Catalan Ana , Kempton Matthew J. , Nelson Barnaby , McGorry Patrick , Riecher-Rössler Anita , Bressan Rodrigo , Barrantes-Vidal Neus , Krebs Marie-Odile , Nordentoft Merete , Ruhrmann Stephan , Sachs Gabriele , Rutten Bart P. F. , van Os Jim , de Haan Lieuwe , van der Gaag Mark ,   EU-GEI High-Risk Study, McGuire Philip , Valmaggia Lucia R. 
Published: January 2023

Abstract

Background
Adverse childhood experiences (ACE) can affect educational attainments, but little is known about their impact on educational achievements in people at clinical high risk of psychosis (CHR).

Methods
In total, 344 CHR individuals and 67 healthy controls (HC) were recruited as part of the European Community’s Seventh Framework Programme-funded multicenter study the European Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI). The brief version of the Child Trauma Questionnaire was used to measure ACE, while educational attainments were assessed using a semi-structured interview.

Results
At baseline, compared with HC, the CHR group spent less time in education and had higher rates of ACE, lower rates of employment, and lower estimated intelligence quotient (IQ). Across both groups, the total number of ACE was associated with fewer days in education and lower level of education. Emotional abuse was associated with fewer days in education in HC. Emotional neglect was associated with a lower level of education in CHR, while sexual abuse was associated with a lower level of education in HC. In the CHR group, the total number of ACE, physical abuse, and neglect was significantly associated with unemployment, while emotional neglect was associated with employment.

Conclusions
ACE are strongly associated with developmental outcomes such as educational achievement. Early intervention for psychosis programs should aim at integrating specific interventions to support young CHR people in their educational and vocational recovery. More generally, public health and social interventions focused on the prevention of ACE (or reduce their impact if ACE occur) are recommended.