bluuebunny/crossref_metadata_2025_split huggingface dataset:
A high‐capacity dual‐ion full battery based on nitrogen‐doped carbon nanosphere anode and concentrated electrolyte
Authors: Wu Hongzheng , Luo Shenghao , Li Li , Xiao Hong , Yuan Wenhui 
Published: May 2023

AbstractDual‐ion batteries (DIBs) are often criticized for their low discharge capacity and poor cyclic capability despite their inherent high working voltage, low manufacturing cost, and environmental friendliness. To solve these shortcomings, many attempts and efforts have been devoted, but all ended in unsatisfactory results. Herein, a hierarchical porous carbon nanosphere anode with ultrahigh nitrogen doping is developed, which exhibits fast ion transport kinetics and excellent Li+ storage capability. Moreover, employing a concentrated electrolyte is expected to bring a series of advantages such as stable SEI for facilitating ion transmission, enhanced cycling performance, high specific capacity, and operation voltage. These advantages endow the assembled full DIBs with excellent performance as a super‐high specific discharge capacity of 351 mAh g−1 and can be cycled stably for 1300 cycles with Coulombic efficiency (CE) remaining at 99.5%; a high operating voltage range of 4.95–3.63 V and low self‐discharge rate of 2.46% h−1 with stable fast charging‐slow discharging performance. Through electrochemical measurements and physical characterizations, the possible working mechanism of the proof‐of‐concept full battery and the structural variations of electrodes during cycling are investigated. The design strategy of novel battery system in this work will promote the development of high‐performance DIBs.
Immune‐check blocking combination multiple cytokines shown curative potential in mice tumor model
Authors: Su Hongxia , Geng Hui , Cai Linkang , Xu Minjie , Xing Wenpin , Long Wei , Liu Biao , Li Yankun , Liu Binlei 
Published: May 2023

AbstractObjectiveIn order to ensure the stable transcription of target genes, we constructed a eukaryotic high expression vector carrying an immune‐check inhibitor PD‐1v and a variety of cytokines, and studied their effects on activating immune response to inhibit tumor growth.MethodsA novel eukaryotic expression plasmid vector named pT7AMPCE containing T7RNA polymerase, T7 promoter, internal ribosome entry site (IRES), and poly A tailing signal was constructed by T4 DNA ligase, on which homologous recombination was used to clone and construct the vector carrying PD‐1v, IL‐2/15, IL‐12, GM‐CSF, and GFP. In vitro transfection of CT26 cells was performed, and the protein expression of PD‐1v, IL‐12 and GM‐CSF was detected by Western blot and ELISA after 48 h. Mice were subcutaneously inoculated with CT26‐IRFP tumor cells in the rib abdomen, and the tumor tissues were injected with PD‐1v, IL‐2/15, IL‐12, and GM‐CSF recombinant plasmids for treatment during the experimental period. The efficacy of the treatment was evaluated by assay tumor size and survival time of tumor‐bearing mice during the experiment. Expression levels of IFN‐γ, TNF, IL‐4, IL‐2, and IL‐5 in mouse blood were measured using the CBA method. Tumor tissues were extracted and immune cell infiltration in tumor tissues was detected by HE staining and the IHC method.ResultsThe recombinant plasmids carrying PD‐1v, IL‐2/15, IL‐12, and GM‐CSF were successfully constructed, and the Western blot and ELISA results showed that PD‐1v, IL‐12, and GM‐CSF were expressed in the supernatant of CT26 cells 48 h after in vitro cell transfection. The combined application of PD‐1v, IL‐2/15, IL‐12, and GM‐CSF recombinant plasmids significantly inhibited tumor growth in mice, and the tumor growth rate was significantly lower than that in the blank control group and GFP plasmid control group (p < 0.05). Cytometric bead array data suggested that the combination of PD‐1v and various cytokines can effectively activate immune cells. HE and IHC analysis revealed plenty of immune cell infiltrates in the tumor tissue, and a large proportion of tumor cells showed the necrotic phenotype in the combination treatment group.ConclusionThe combination of immune check blockade and multiple cytokine therapy can significantly activate the body's immune response and inhibit tumor growth.
Insights into the leveraging of GABAergic signaling in cancer therapy
Authors: Li Tian‐Jiao , Jiang Jian , Tang Ya‐Ling , Liang Xin‐Hua 
Published: May 2023

AbstractGamma‐aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain of adult mammals. Several studies have demonstrated that the GABAergic system may regulate tumor development via GABA receptors, downstream cyclic adenosine monophosphate (cAMP) pathway, epithelial growth factor receptor (EGFR) pathway, AKT pathway, mitogen‐activated protein kinase (MAPK) or extracellular signal‐related kinases (ERK) pathway, and matrix metalloproteinase (MMP) pathway, although the exact mechanism is unclear. Pioneering studies reported that GABA signaling exists and functions in the cancer microenvironment and has an immunosuppressive effect that contributes to metastasis and colonization. This article reviews the molecular structures and biological functions of GABAergic components correlated with carcinogenesis, the mechanisms underlying GABAergic signaling that manipulate the proliferation and invasion of cancer cells, and the potential GABA receptor agonists and antagonists for cancer therapy. These molecules may provide an avenue for the development of specific pharmacological components to prevent the growth and metastasis of various cancers.
The prognostic role of cigarette smoking in Kidney Cancer Survival
Authors: Baral Amrit , Cranford Hannah M. , Sharma Janaki , Pinheiro Paulo S. 
Published: May 2023

AbstractBackgroundThe role of cigarette smoking as a prognostic factor for kidney cancer (KC) is unclear. In this population‐based study, we analyze cancer‐specific survival (CSS) outcomes among KC patients by smoking status at diagnosis in the diverse state of Florida.MethodsAll primary KC cases from the Florida Cancer Registry diagnosed during 2005–2018 were analyzed. Cox proportional regression was conducted to assess the determinants of KC survival, including age, sex, race/ethnicity, socioeconomic status, histology type, cancer stage, and treatment received with a particular focus on smoking status (smokers at diagnosis referred to as current smokers, former smokers, and never smokers).ResultsAmong all 36,150 KC patients, 18.3% were smokers at diagnosis (n = 6629), 32.9% were former smokers (n = 11,870), and 48.8% were never smokers (n = 17,651). Age‐standardized five‐year survival for current, former, and never smokers was 65.3 (95% CI: 64.1–66.5), 70.6 (95% CI: 69.7–71.5), and 75.3 (95% CI: 74.6–76.0) respectively. In multivariable analysis, current and former smokers had an estimated 30% and 14% higher risk of KC death compared to never smokers, respectively, after adjusting for potential confounders (HR: 1.30, 95% CI: 1.23–1.40; HR: 1.14, 95% CI: 1.10–1.20).ConclusionSmoking independently contributes to poorer survival, across all KC stages. Clinicians should encourage and facilitate participation in cigarette smoking cessation programs targeted at current smokers. Prospective studies are warranted to assess the role of different types of tobacco use and cessation programs on KC survival.
Association between papillary thyroid carcinoma and cervical lymph node metastasis based on ultrasonic radio frequency signals
Authors: Zhou Liuhua , Zheng Yi , Yao Jincao , Chen Liyu , Xu Dong 
Published: May 2023

AbstractObjectivePapillary thyroid carcinoma (PTC) has a high propensity for cervical lymph node metastasis (CLNM). We evaluated the association between PTC radio frequency (RF) signals and CLNM.MethodsPatients with PTC (n = 170) confirmed by pathology after thyroidectomy between July 2019 and May 2022 were enrolled in this retrospective cohort study. Patients were divided into positive and negative groups according to CLNM. Univariate analysis was performed to predict CLNM and a receiver operating characteristic (ROC) curve was generated to evaluate the diagnostic performance of RF signals and the Thyroid imaging Reporting and Data System.ResultsOf 170 patients with 182 nodules included in the study, 11 had multiple nodules. Univariate analysis showed that age, maximum tumor diameter, cross‐sectional and longitudinal aspect ratio, RF quantitative parameters (cross‐sectional intercept, mid‐band, S1, and S4, and longitudinal Higuchi, slope, intercept, mid‐band, S1), and echogenic foci were independently associated with CLNM (p < 0.05). The area under the curve (AUC) values of the maximum tumor diameter, longitudinal slope, and echogenic foci were 0.68, 0.61, and 0.62, respectively. Linear regression analysis of maximum tumor diameter, longitudinal slope, and echogenic foci showed that the correlations between longitudinal slope and CLNM were greater than that of echogenic foci (ß = 0.203 vs. ß = 0.154).ConclusionLongitudinal slope and echogenic foci have similar diagnostic efficacy for predicting the risk of CLNM in PTC, although longitudinal slope has a greater correlation with CLNM.
An interaction design model for virtual reality mindfulness meditation using imagery‐based transformation and positive feedback
Authors: She Yingying , Wang Qing , Liu Fang , Lin Lin , Yang Baorong , Hu Bin 
Published: May 2023

AbstractIn recent years, mindfulness meditation has become increasingly popular as a way to relieve negative emotions. Although many studies have shown the advantages of the most immersive virtual reality (VR) technologies to support mindfulness meditation, few have summarized a standardized process for developing a VR tool to aid mindfulness meditation. We propose an interaction design model for VR mindfulness meditation using imagery‐based transformation and positive feedback to help users quickly soothe their negative emotions. Based on the traditional mindfulness meditation model, we propose the three detailed transformational steps to build (1) an interaction guidance process, (2) an interaction experience context, and (3) an interaction feedback mechanism. We build two scenarios based on them. Our experimental results suggest that our design can effectively alleviate a user's anxiety and provide emotional relief. Our insights on the transformation model of VR mindfulness meditation can be applied in related research, providing an effective reference model for VR mindfulness meditation systems, while providing new ideas for non‐pharmacological interventions in psychotherapy.
Interlinking of diabetes mellitus and cancer: An overview
Authors: Ahmad Iftikhar , Suhail Mohd , Ahmad Ausaf , Alhosin Mahmoud , Tabrez Shams 
Published: May 2023

AbstractCancer and diabetes mellitus (DM) are among the leading causes of mortality and morbidity in the global arena. Lately, several studies demonstrated that DM could promote cancer. However, the exact mechanism(s) highlighting this association are largely untouched and require comprehensive detailing. In the present review, we aimed to explore and decipher the possible mechanism of DM an cancer association. Hyperglycemia could be a subordinate plausible explanation of carcinogenesis in the diabatic patient. It is well known that high glucose levels may help in cancer proliferation. In addition, chronic inflammation, the other well‐known factor of diabetes, could also play a role in carcinogenesis. Moreover, the numerous medicines to treat diabetes either increase or reduce cancer risk. Insulin is one of the potent growth factors that promotes cell propagation and induces cancer directly or via insulin like growth factor‐1. On the other hand, hyperinsulinemia leads to an increased activity of growth factor‐1 by inhibiting growth factor binding protein‐1. To improve cancer prognosis, individuals with diabetes should be screened to discover cancer at an early stage and treated appropriately.
Protein Modification via Nitrile Oxide−Dehydroalanine Cycloaddition: Formation of Isoxazoline Ring on the Protein Backbone
Authors: Phanumartwiwath Anuchit , Kesornpun Chatchai , Chokchaichamnankit Daranee , Khongmanee Amnart , Diskul‐Na‐Ayudthaya Penchatr , Ruangjaroon Theetat , Srisomsap Chantragan , Kittakoop Prasat , Svasti Jisnuson , Ruchirawat Somsak 
Published: May 2023

AbstractHere we describe a novel catalyst‐free 1,3‐dipolar cycloaddition bioconjugation approach for chemical modification of proteins. The dehydroalanine (Dha)‐containing protein reacts with nitrile oxides generated in situ through 1,3‐dipolar cycloaddition in fully aqueous‐buffered systems. This leads to the formation of a new isoxazoline ring at a pre‐defined site (Dha) of the protein. Furthermore, the 1‐pyrene isoxazoline‐installed annexin V acts as a fluorescent probe, which successfully labels the outer cellular membranes of human cholangiocarcinoma (HuCCA‐1) cells for detection of apoptosis.
Alkali Metal Halide Ion‐Pair Binding in Conformationally Dynamic Halogen Bonding Heteroditopic [2]Rotaxanes
Authors: Min Tay Hui , Docker Andrew , Cheong Tse Yuen , Beer Paul D. 
Published: May 2023

AbstractA series of heteroditopic halogen bonding (XB) [2]rotaxanes were prepared via a combination of passive and active metal template‐directed strategies. The ability of the [2]rotaxanes to bind alkali metal halide ion‐pairs was investigated by extensive 1H NMR titration studies, wherein detailed analysis of cation, anion and ion‐pair affinity measurements indicate dramatic positive cooperative enhancements in halide anion association upon either Na+ or K+ pre‐complexation. This study demonstrates that careful consideration of multiple, parallel and competing binding equilibria is essential when interpreting observed 1H NMR spectral changes in ion‐pair receptor systems, especially those which exhibit dynamic behaviour. Importantly, in comparison to XB [2]catenane analogues, these neutral XB heteroditopic [2]rotaxane host systems demonstrated that despite their relatively weaker cation and anion binding affinities, they exhibit a notably higher level of positive cooperativity for alkali metal halide ion‐pair binding, highlighting the role of greater co‐conformational adaptive behaviour in mechanically‐bonded hosts for the purposes of charged species recognition.
Transformation of Mytella falcata residual shell into CaAl/LDH adsorbent: Removal of methyl orange and methylene blue dyes
Authors: Henrique Diogo Carlos , Henrique Daniely Carlos , Duarte José Leandro da Silva , Georgin Jordana , Franco Dison Stracke Pfingsten , Meili Lucas 
Published: May 2023

AbstractThis study analyzed the viability of using malacoculture residue (Mytella falcata) to produce layered double hydroxides (LDHs) and for its subsequent use as an adsorbent. The CaAl/LDH‐RE material was produced with calcium oxide from the residue and the CaAl/LDH‐AP was produced with a commercial reagent. Both were used to remove methyl orange (MO) and methylene blue (MB) dyes. The CaAl/LDH‐RE presented a surface area of 28.54 m2 g−1, being 65.62% larger than the CaAl/LDH‐AP material (17.23 m2 g−1). The adsorbents showed mesopores distributed on a surface formed by plates in the form of hexagonal sheets arranged in an overlapping manner. The dosage of 0.05 g L−1 obtained the removal of 95% and 97% for MO, while for MB it was 94% and 93% using the adsorbents LDH/CaAl‐AP and LDH/CaAl‐RE, respectively. The system reached equilibrium at 90 min for MO and 120 min for MB. The pseudo‐second order model well represented the kinetic data reaching 11.36 mg g−1 (CaAl/LDH‐RE) and 8.42 mg g−1 (CaAl/LDH‐AP) for MO, and 4.47 mg g−1 (CaAl/LDH‐RE) and 4.14 mg g−1 (CaAl/LDH‐AP) for MB. The Freundlich model better represented the isothermal data, where the temperature exerted little influence. Adsorbents showed similar removal percentages in real and synthetic matrices. The LDH/CaAl‐RE can be applied in up to 3 cycles, maintaining its adsorption capacity. These results corroborate the use of MFW to produce CaAl/LDH‐RE, which can be used for the efficient removal of organic pollutants in an aqueous solution.
Safety and efficacy of ablation index‐guided atrial fibrillation ablation in octogenarians
Authors: Okamatsu Hideharu , Okumura Ken , Onishi Fumitaka , Yoshimura Akino , Negishi Kodai , Tsurugi Takuo , Tanaka Yasuaki , Nakao Koichi , Sakamoto Tomohiro , Koyama Junjiro 
Published: May 2023

AbstractBackgroundLimited data on the efficacy and safety of atrial fibrillation (AF) ablation using an ablation index (AI) for octogenarians is available. We aimed to compare the efficacy and safety of AI‐guided AF ablation between AF patients aged ≥80 years (Group 1) and <80 (Group 2).HypothesisWe hypothesized that AI‐guided AF ablation could complete the procedure with comparable efficiency and safety in patients aged ≥80 years and <80.MethodsWe retrospectively reviewed 2087 AF patients undergoing their first AI‐guided AF ablation in our hospital. We compared the atrial tachyarrhythmia (AT) recurrence and procedure‐related complication rate between Group 1 (n = 193) and Group 2 (n = 1894).ResultsThe mean age was 83.0 (interquartile range [IQR] 81.0, 84.0) years in Group 1 and 67.0 (IQR 60.0, 72.0) in Group 2. AF type was significantly different between the two groups: Of Group 1 patients, 120 (62.2%) had paroxysmal AF, 61 (31.6%) persistent AF, and 12 (6.2%) long‐standing persistent AF, while of Group 2 patients, 1016 (53.6%) paroxysmal AF, 582 (30.7%) persistent AF, and 296 (15.6%) long‐standing persistent AF (p = .001). Unadjusted AT recurrence‐free survival curves showed similar AT recurrence‐free survival between the two groups (p = .67 by log‐rank test). After the adjustment for AF type, the survival curve was similar between them (hazard ratio, 1.24; 95% CI [0.92–1.65]; p = .15, Group 1 vs. Group 2). The rate of procedure‐related complications was similar between the two groups (3.1% vs. 3.0%, respectively, p = .83).ConclusionCatheter ablation guided by AI achieved similar AT recurrence and complication rates between elderly AF patients aged ≥80 years and patients <80 years.
Comparison of blue laser imaging and light‐emitting diode‐blue light imaging for the characterization of colorectal polyps using the Japan narrow‐band imaging expert team classification: The LASEREO and ELUXEO COLonoscopic study
Authors: Okada Masahiro , Yoshida Naohisa , Kashida Hiroshi , Hayashi Yoshikazu , Shinozaki Satoshi , Yoshimoto Shiori , Fujinuma Toshihiro , Sakamoto Hirotsugu , Sunada Keijiro , Tomita Yuri , Dohi Osamu , Inoue Ken , Hirose Ryohei , Itoh Yoshito , Komeda Yoriaki , Sekai Ikue , Okai Natsuki , Lefor Alan Kawarai , Yamamoto Hironori 
Published: May 2023

AbstractObjectivesAlthough the laser light is optically ideal for producing narrow‐band light, it has not been used in some areas of the world. Endoscopic light sources using light‐emitting diodes (LEDs) are used worldwide. The purpose of this study was to compare blue laser imaging (laser‐BLI) and LED‐blue light imaging (LED‐BLI) for the characterization of colorectal polyps using the Japan narrow band imaging expert team (JNET) classification.MethodsColorectal lesions were prospectively examined using magnifying narrow‐band light generated by a laser (laser‐BLI) or LEDs (LED‐BLI). Twelve endoscopists (six non‐experts and six experts from three institutions) evaluated each still‐magnified image of lesions using the JNET classification.ResultsSeven hundred and fifty‐six images from 63 lesions were reviewed. The mean polyp size was 24.5 ± 13.4 mm. Histopathology included 13 serrated lesions and 50 neoplasms. The rate of agreement between laser‐BLI and LED‐BLI using the JNET classification was 92.5% (699/756). The weighted κ‐statistic was 0.99. The percentages of “almost similar” comparing scores of surface patterns, vessel patterns, and brightness among all endoscopists were 95.4%, 95.9%, and 95.0%, respectively.ConclusionsThis multicenter study demonstrates that the rate of agreement between laser‐BLI and LED‐BLI using the JNET Classification is very high. The surface patterns, vessel patterns, and brightness are almost similar.
Habitat and climatic associations of climate‐sensitive species along a southern range boundary
Authors: Wilson Evan C. , Cousins Stella , Etter Dwayne R. , Humphreys John M. , Roloff Gary J. , Carter Neil H. 
Published: May 2023

AbstractClimate change and habitat loss are recognized as important drivers of shifts in wildlife species' geographic distributions. While often considered independently, there is considerable overlap between these drivers, and understanding how they contribute to range shifts can predict future species assemblages and inform effective management. Our objective was to evaluate the impacts of habitat, climatic, and anthropogenic effects on the distributions of climate‐sensitive vertebrates along a southern range boundary in Northern Michigan, USA. We combined multiple sources of occurrence data, including harvest and citizen‐science data, then used hierarchical Bayesian spatial models to determine habitat and climatic associations for four climate‐sensitive vertebrate species (American marten [Martes americana], snowshoe hare [Lepus americanus], ruffed grouse [Bonasa umbellus] and moose [Alces alces]). We used total basal area of at‐risk forest types to represent habitat, and temperature and winter habitat indices to represent climate. Marten associated with upland spruce‐fir and lowland riparian forest types, hares with lowland conifer and aspen‐birch, grouse with lowland riparian hardwoods, and moose with upland spruce‐fir. Species differed in climatic drivers with hares positively associated with cooler annual temperatures, moose with cooler summer temperatures and grouse with colder winter temperatures. Contrary to expectations, temperature variables outperformed winter habitat indices. Model performance varied greatly among species, as did predicted distributions along the southern edge of the Northwoods region. As multiple species were associated with lowland riparian and upland spruce‐fir habitats, these results provide potential for efficient prioritization of habitat management. Both direct and indirect effects from climate change are likely to impact the distribution of climate‐sensitive species in the future and the use of multiple data types and sources in the modelling of species distributions can result in more accurate predictions resulting in improved management at policy‐relevant scales.
Aging‐related histone modification changes in brain function
Authors: Ding Yanwen , Liu Chengxi , Zhang Yi 
Published: May 2023

AbstractAging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging‐related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated.