bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloperoxidase enhances the migration of human choriocarcinoma JEG-3 cells1
Authors: Mihalic ZN. , Kloimböck T. , Cosic-Mujkanovic N. , Valadez-Cosmes P. , Maitz K. , Kindler O. , Wadsack C. , Heinemann A. , Marsche G. , Gauster M. , Pollheimer J. , Kargl J. 
Published: January 2023

ABSTRACTMyeloperoxidase (MPO) is one of the most abundant proteins in neutrophil granules. It catalyzes the production of reactive oxygen species, which are important in inflammation and immune defense. MPO also binds to several proteins, lipids, and DNA to alter their function. MPO is present at the feto-maternal interface during pregnancy, where neutrophils are abundant. In this study, we determined the effect of MPO on JEG-3 human choriocarcinoma cells as a model of extravillous trophoblasts (EVTs) during early pregnancy. We found that MPO was internalized by JEG-3 cells and localized to the cytoplasm and nuclei. MPO internalization and activity enhanced JEG-3 cell migration, whereas this effect was impaired by pre-treating cells with heparin, to block cellular uptake, and MPO-activity inhibitor 4-ABAH. This study identifies a novel mechanism for the effect of MPO on EVT function during normal pregnancy and suggests a potential role of MPO in abnormal pregnancies.GRAPHICAL ABSTRACT
Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases
Authors: Cason Sydney E. , Holzbaur Erika L.F. 
Published: January 2023

AbstractNeuronal autophagosomes, “self-eating” degradative organelles, form at presynaptic sites in the distal axon and are transported to the soma to recycle their cargo. During transit, autophagic vacuoles (AVs) mature through fusion with lysosomes to acquire the enzymes necessary to breakdown their cargo. AV transport is driven primarily by the microtubule motor cytoplasmic dynein in concert with dynactin and a series of activating adaptors that change depending on organelle maturation state. The transport of mature AVs is regulated by the scaffolding proteins JIP3 and JIP4, both of which activate dynein motility in vitro. AV transport is also regulated by ARF6 in a GTP-dependent fashion. While GTP-bound ARF6 promotes the formation of the JIP3/4-dynein-dynactin complex, RAB10 competes with the activity of this complex by increasing kinesin recruitment to axonal AVs and lysosomes. These interactions highlight the complex coordination of motors regulating organelle transport in neurons.SummaryMature autophagosomes in the axon are transported by the microtubule motor dynein, activated by JNK-interacting proteins 3 and 4 (JIP3/4). This motility is regulated by the small GTPases ARF6 and RAB10. The tight regulation of autolysosomal transport is essential for intracellular recycling to maintain neuronal homeostasis.
Cell fate specification and conversion generate foveolar cone subtype patterning in human retinal organoids
Authors: Hussey Katarzyna A. , Eldred Kiara , Guy Brian , Santiago Clayton , Glass Ian , Reh Thomas A. , Blackshaw Seth , Goff Loyal A. , Johnston Robert J. 
Published: January 2023

AbstractThe mechanisms that generate patterns of cell types unique to humans are poorly understood. In the central region of the human retina, the high-acuity foveola is notable, in part, for its dense packing of green (M) and red (L) cones and absence of blue (S) cones. To identify mechanisms that promote M/L and suppress S cone patterning in the foveola, we examined human fetal retinas and differentiated human retinal organoids. During development, sparse S-opsin-expressing cones are initially observed in the foveola. Later in fetal development, the foveola contains a mix of cones that either co-express S- and M/L-opsins or exclusively express M/L-opsin. In adults, only M/L cones are present. Two signaling pathway regulators are highly and continuously expressed in the central retina: Cytochrome P450 26 subfamily A member 1 (CYP26A1), which degrades retinoic acid (RA) and Deiodinase 2 (DIO2), which promotes thyroid hormone (TH) signaling. BothCYP26A1null mutant organoids and high RA conditions increased the number of S cones and reduced the number of M/L cones in human retinal organoids. In contrast, sustained TH signaling promoted the generation of M/L-opsin-expressing cones and induced M/L-opsin expression in S-opsin-expressing cones, showing that cone fate is plastic. Our data suggest that CYP26A1 degrades RA to specify M/L cones and limit S cones and that continuous DIO2 expression sustains high levels of TH to convert S cones into M/L cones, resulting in the foveola containing only M/L cones. Since the foveola is highly susceptible to impairment in diseases such as macular degeneration, a leading cause of vision loss, our findings inform organoid design for potential therapeutic applications.
Adoption of cryptocurrencies for remittances in the UAE: the mediation effect of consumer innovation
Authors: Jegerson Devid , Khan Mehmood , Mertzanis Charilaos 
Published: January 2023

PurposeThis study investigated the internal factors that influence the adoption of cryptocurrencies for remittance transactions in the United Arab Emirates (UAE) by examining the relationships between behavioural intention (BI) and perceived risk (PR), as well as the mediating effect of consumer innovation (CI).Design/methodology/approachThe authors developed a structural model using scales from the literature. The authors distributed an online questionnaire, evaluated by five cryptocurrency experts, using a snowball approach and collected 270 responses.FindingsThe results revealed that CI mediates the relationship between PR and BI. Also, CI enhances intentions to use cryptocurrencies for remittance transactions. However, PR has a negative impact on BI.Research limitations/implicationsThis research adds to the body of knowledge by examining the acceptance and implementation of cryptocurrencies in the UAE and by developing and evaluating new constructs based on current notions. The study also contributes to the current understanding of cryptocurrencies and blockchain adoption. This article focusses on the mediating impact of CI on intentions to employ cryptocurrency instruments for international money transfers.Practical implicationsThe conclusions of the research give advice for marketers on how to boost the commercialisation of cryptocurrencies in the UAE remittance market and may pave the way for other studies to assist impending developments in the UAE cryptocurrency industry.Originality/valueThis research offers novel insights into CI as a significant predictor of bitcoin product uptake in the remittance business.
Effect of a student teaching internship program on the self-efficacy of pre-service teachers in rural China
Authors: Cheung Alan Chi Keung , Wong Koon Lin , Wang Hong Fang , Dai Jian Bing 
Published: January 2023

PurposeThe purpose of the present study was to examine the impact of a student teaching internship program on the self-efficacy of pre-service teachers in China.Design/methodology/approachWith 1,367 participants, structural equation modelling was used to evaluate the fit of the hypothetical model and a latent path analysis was conducted to identify the relationship among various variables.FindingsThe results suggested that the program had a significant impact on efficacy in terms of personal skills, general teaching skills and personal qualities of the student interns concerned. Although this study was set in rural China, the findings of this study offered insights for teacher education in other places.Originality/valueTo the best of our knowledge, no research studies have been conducted on this in-service teacher training program in a systematic and comprehensive way using a large sample size and involving all major stakeholders. The aim of the present study is to fill this gap, by exploring the experience of a large cohort of pre-service teachers participating in this student teaching internship program. Studying the experiences of these student teachers will illuminate some of the key challenges faced and how they impacted their teaching and learning during their teaching practices in rural areas. The findings may help teacher education institutions to review and enhance their existing approaches to teaching practices and professional development initiatives not only in rural China but in similar contexts in other countries.
How can CSR in demarketing trigger brand advocacy and mindful consumption? Mediating roles of perceived corporate hypocrisy and brand credibility
Authors: Pham Hoa , Dang Huu Phuc , Nguyen-Viet Bang 
Published: February 2023

PurposeThe call for consumption reduction behavior has been getting more attention from scholars and practitioners. However, the consumption reduction often receives backfire from consumers because it does not follow the business philosophy of demand creation. Thus, this research dissolves this issue by using a holistic corporate social responsibility (CSR) approach regarding sustainable development.Design/methodology/approachA conceptual model was developed to represent the proposed relationships among the related variables. The current study employed an online survey to collect data from 341 international program students of three prominent universities in Ho Chi Minh City, Vietnam.FindingsThe findings indicate that the perception of the holistic CSR negatively impacts perceived corporate hypocrisy, triggering in turn brand credibility, resulting in brand advocacy and mindful consumption behavior.Originality/valueThis research forms a holistic CSR including economic, environmental and societal dimensions and proposes that the holistic CSR triggers brand advocacy and mindful consumption behavior representing consumption reduction behavior via the mediating roles of perceived corporate hypocrisy and brand credibility. These findings contribute to theoretical and managerial implications in CSR practices with the aim of consumption reduction.
The role of HEXACO in the development of authentic leadership and its consequences on task performance
Authors: Malik Muhammad Faisal , Burhan Qurat-ul-Ain , Khan Muhammad Asif 
Published: January 2023

PurposeThe objectives of the current study were to identify the antecedents and outcomes of authentic leadership. For antecedents, the research considered the HEXACO (Honesty-Humility, Emotionality, eXtraversion, Agreeableness, Conscientiousness, Openness to Experience) personality model and thereby identified the impact of authentic leadership on employee performance with the mediating role of psychological safety and employee engagement by using the trait theory.Design/methodology/approachThe current study adopted a positivism research philosophy followed by a deductive approach. Overall, 347 samples were collected from the public sector organizations using quantitative research techniques, and data were gathered through a self-administrated questionnaire. Exploratory and confirmatory factor analyses were used through structural equation modeling (SEM)-Mplus to generate the results and test the formulated hypotheses.FindingsThe results revealed that honesty-humility significantly impacts authentic leadership (β = 0.094 and p < 0.05). Similarly, other dimensions of HEXACO also play a significant role in forming authentic leadership. After analyzing the HEXACO as the antecedent of authentic leadership, sequential mediation of psychological safety and employee engagement was checked and identified that authentic leadership in the presence of mediators was insignificant. Hence the full mediation has been recorded.Originality/valueSince its inception, a plethora of research has been available on the authentic leadership theory. However, the empirical evidence revealed that most research is related to outcomes of authentic leadership. As far as antecedents of authentic leadership are concerned, the literature is still silent, specifically on the development of authentic leaders. The current study is significantly contributing to the theory of authentic leadership, and in this context, the study is unique since it is taking the HEXACO personality model as an antecedent of authentic leadership to investigate its role in the development of authentic leaders. Moreover, the study is also identified as the impact of authentic leadership on task performance, not in isolation, but by taking psychological safety and employee engagement as a mediating mechanism.
CVD processed ZnO thin film as solid thermal interface material in electronic devices: thermal and optical performance of LED
Authors: Subramani Shanmugan , Devarajan Mutharasu 
Published: February 2023

Purpose
Polymer-based thermal interface materials (TIMs) are having pump out problem and could be resolved for reliable application. Solid-based interface materials have been suggested and reported. The purpose of this paper is suggesting thin film-based TIM to sustain the light-emiting diode (LED) performance and electronic device miniaturization.

Design/methodology/approach
Consequently, ZnO thin film at various thicknesses was prepared by chemical vapour deposition (CVD) method and tested their thermal behaviour using thermal transient analysis as solid TIM for high-power LED.

Findings
Low value in total thermal resistance (Rth-tot) was observed for ZnO thin film boundary condition than bare Al boundary condition. The measured interface (ZnO thin film) resistance {(Rth-bhs) thermal resistance of the interface layer (thin film) placed between metal core printed circuit board (MCPCB) board and Al substrates} was nearly equal to Ag paste boundary condition and showed low values for ZnO film prepared at 30 min process time measured at 700 mA. The TJ value of LED mounted on ZnO thin film (prepared at 30 min.) coated Al substrates was measured to be 74.8°C. High value in junction temperature difference (ΔTJ) of about 4.7°C was noticed with 30 min processed ZnO thin film when compared with Al boundary condition. Low correlated colour temperature and high luminous flux values of tested LED were also observed with ZnO thin film boundary condition (processed at 30 min) compared with both Al substrate and Ag paste boundary condition.

Originality/value
Overall, 30 min CVD processed ZnO thin film would be an alternative for commercial TIM to achieve efficient thermal management. This will increase the life span of the LED as the proposed material decreases the TJ values.
Body impedance analysis to estimate malnutrition in inflammatory bowel disease patients – A cross‐sectional study
Authors: Reiner Johannes , Koch Kristina , Woitalla Julia , Huth Astrid , Bannert Karen , Sautter Lea , Jaster Robert , Witte Maria , Lamprecht Georg , Schäffler Holger 
Published: January 2023

ObjectiveMalnutrition is a common clinical problem in patients with inflammatory bowel diseases (IBD). However, a gold standard for the detection of malnutrition in IBD patients is lacking.MethodsA cross‐sectional study to assess malnutrition in patients with IBD and healthy controls (HCs). Clinical characteristics (Montreal classification, disease activity, previous surgery) and mutations in the NOD2 gene in patients with Crohn's disease (CD) were obtained. We performed a nutritional assessment with screening for nutritional risk and diagnosis for malnutrition (Malnutrition Universal Screening Tool [MUST]) score, NRS‐2002, European Society for Clinical Nutrition and Metabolism (ESPEN), and Global Leadership Initiative on Malnutrition (GLIM) criteria and performed body impedance analysis (BIA).Results101 IBD patients (57 CD and 44 ulcerative colitis (UC) and 50 HC were included in a single northern German tertiary center. GLIM criteria detected malnutrition significantly more often compared to the ESPEN criteria. Active disease, a long‐standing disease course, and previous surgery were associated with reduced muscle mass. IBD patients had a higher fat mass index compared to HC. Mutations in the NOD2 gene had no effect on nutritional status.ConclusionsThe GLIM criteria detect malnutrition at a higher rate compared to ESPEN. Specific disease factors might put IBD patients at a higher risk for the development of malnutrition, so these patients might benefit from a frequently performed screening, which might result in a favorable disease course.
BirdFlow: Learning seasonal bird movements from eBird data
Authors: Fuentes Miguel , Van Doren Benjamin M. , Fink Daniel , Sheldon Daniel 
Published: February 2023

Abstract

Large‐scale monitoring of seasonal animal movement is integral to science, conservation and outreach. However, gathering representative movement data across entire species ranges is frequently intractable. Citizen science databases collect millions of animal observations throughout the year, but it is challenging to infer individual movement behaviour solely from observational data.

We present BirdFlow, a probabilistic modelling framework that draws on citizen science data from the eBird database to model the population flows of migratory birds. We apply the model to 11 species of North American birds, using GPS and satellite tracking data to tune and evaluate model performance.

We show that BirdFlow models can accurately infer individual seasonal movement behaviour directly from eBird relative abundance estimates. Supplementing the model with a sample of tracking data from wild birds improves performance.

Researchers can extract a number of behavioural inferences from model results, including migration routes, timing, connectivity and forecasts. The BirdFlow framework has the potential to advance migration ecology research, boost insights gained from direct tracking studies and serve a number of applied functions in conservation, disease surveillance, aviation and public outreach.
An exact version of Life Table Response Experiment analysis, and the R package exactLTRE
Authors: Hernández Christina M. , Ellner Stephen P. , Adler Peter B. , Hooker Giles , Snyder Robin E. 
Published: February 2023

Abstract

Matrix population models are frequently built and used by ecologists to analyse demography and elucidate the processes driving population growth or decline. Life Table Response Experiments (LTREs) are comparative analyses that decompose the realized difference or variance in population growth rate () into contributions from the differences or variances in the vital rates (i.e. the matrix elements). Since their introduction, LTREs have been based on approximations and have not included biologically relevant interaction terms.

We used the functional analysis of variance framework to derive an exact LTRE method, which calculates the exact response of to the difference or variance in a given vital rate, for all interactions among vital rates—including higher‐order interactions neglected by the classical methods. We used the publicly available COMADRE and COMPADRE databases to perform a meta‐analysis comparing the results of exact and classical LTRE methods. We analysed 186 and 1487 LTREs for animal and plant matrix population models, respectively.

We found that the classical methods often had small errors, but that very high errors were possible. Overall error was related to the difference or variance in the matrices being analysed, consistent with the Taylor series basis of the classical method. Neglected interaction terms accounted for most of the errors in fixed design LTRE, highlighting the importance of two‐way interaction terms. For random design LTRE, errors in the contribution terms present in both classical and exact methods were comparable to errors due to neglected interaction terms. In most examples we analysed, evaluating exact contributions up to three‐way interaction terms was sufficient for interpreting 90% or more of the difference or variance in .

Relative error, previously used to evaluate the accuracy of classical LTREs, is not a reliable metric of how closely the classical and exact methods agree. Error compensation between estimated contribution terms and neglected contribution terms can lead to low relative error despite faulty biological interpretation. Trade‐offs or negative covariances among matrix elements can lead to high relative error despite accurate biological interpretation. Exact LTRE provides reliable and accurate biological interpretation, and the R package exactLTRE makes the exact method accessible to ecologists.
Corporate carbon assurance and the quality of carbon disclosure
Authors: Luo Le , Tang Qingliang , Fan Hanlu , Ayers Jamie 
Published: January 2023

AbstractBased on an international sample, this study examines the association between corporate carbon assurance and carbon disclosure. We find that companies that adopt carbon assurance tend to have better carbon disclosure quality than their unassured peers. Cross‐sectional analyses demonstrate that the positive relationship is stronger in stakeholder‐oriented countries. We also document that carbon assurance plays a substitutive role for country‐level carbon regulation and social trust. Further analyses suggest that carbon assurance has differential impacts on specific types of carbon disclosure and the quality of carbon disclosure increases with the percentage of reported emissions assured and the level of carbon assurance.
The effects of Tech‐Fin on corporate innovation: Evidence from China
Authors: Feng Chen , Hu Qing‐Yuan , Kang Yan‐Kun , Li Cheng‐Yao , Zhang Yao 
Published: January 2023

AbstractThis paper uses the multi‐period difference‐in‐differences (DID) method to empirically test the effects of Tech‐Fin on the innovation output of companies based on a quasi‐natural experiment to examine China's Tech‐Fin pilot city reform. We find that Tech‐Fin significantly increased the innovation output of high‐tech companies in the pilot cities and in cities with weak intellectual property protection. In addition, Tech‐Fin had no significant effects on the innovation output of pseudo‐high‐tech companies and technology‐intensive high‐tech companies. We further find that Tech‐Fin motivated high‐tech companies to increase their innovation output through innovation correction and risk‐smoothing effects.
Government provided rating, alleviation of financial constraints, and corporate investment
Authors: Li Jinyang , Wang Jenny Jing , Yu Minggui 
Published: January 2023

AbstractThe State Taxation Administration (STA) of China established the tax credit rating system in 2015. Together with the banking regulatory authorities, STA entitles the higher‐level firms to favourable bank lending. We find that higher‐level firms are positively associated with capital investment, R&D expenditures and employment. These effects are more pronounced in private firms, small firms, and financially constrained firms. We identify that firms rated higher‐level receive more debt financing at lower cost, and hoard less cash for the precautionary reasons. Our findings highlight the importance of the government rating, especially a developed credit rating market in which is absence in emerging economies.
The impact of board ethnic diversity on executive pay‐to‐performance sensitivity: Australian evidence
Authors: Do Truc (Peter) 
Published: January 2023

AbstractWe examine how board ethnic diversity impacts executive pay‐to‐performance sensitivity. Using firm‐year observations in Australia for the period 2007–2017, we document that board ethnic diversity leads to higher executive pay‐to‐performance sensitivity. The finding is robust in controlling for endogeneity using instrumental variable regression analysis, as well as using modified measures of board ethnic diversity. We also document that the impact of board ethnic diversity on executive pay‐to‐performance sensitivity is more pronounced for firms suffering from high agency costs and when the CEO's ethnicity is different from that of the majority of the board. This study helps to inform the debate on the issue of board ethnic diversity in Australia.