bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan Diet Rendah Purin dan Pemeriksaan Kadar Asam Urat Darah sebagai Upaya Pencegahan Penyakit Akibat Hiperurisemia
Authors: Musa Inna Mutmainnah , Indarwati Abdullah Rezky Putri , Akbar Muhammad Alief , Ramadhan Wafi 
Published: February 2023

Konsumsi makanan yang mengandung purin berlebih menyebabkan terjadinya peningkatan produksi asam urat di dalam darah (hiperurisemia). Kristal asam urat yang berlebih akan menumpuk di dalam sendi dan menyebabkan penyakit gout arthritis dan apabila menumpuk di ginjal akan mengakibatkan batu ginjal. Menurut Riskesdas pada tahun 2018, prevalensi penyakit asam urat berdasarkan berdasarkan diagnosis atau gejala sebesar 24,7% jika dilihat dari karateristik umur, prevalensi tertinggi pada umur ≥ 75 tahun (54,8%). Penderita wanita juga lebih banyak (8,46%) dibandingkan dengan pria (6,13%). Meskipun angka kejadian gout arthritis dan penyakit lain akibat hiperurisemia cukup tinggi, namun sebagian besar masyarakat belum banyak mengetahui informasi mengenai diet rendah purin dan jarang melakukan skrining kadar asam urat. Upaya pencegahan hiperurisemia membutuhkan partisipasi dari semua pihak, baik dokter pemerintah, swasta maupun masyarakat, agar hiperurisemia dapat dikendalikan. Pemberian pelatihan partisipatif kepada masyarakat dengan melibatkan peran serta mitra melalui kegiatan ceramah dan diskusi. Selain itu, menambah pengetahuan dan pemahaman masyarakat mengenai diet rendah purin, memberikan bahan ajar seperti banner dan flipchart bergambar yang mudah dimengerti dan dapat dipergunakan setelah kegiatan ini serta mengetahui kadar asam urat darah warga sekitar.
Desain latihan teknik dasar passing dan kontrol pada sepakbola
Authors: Budiono Budiono , Imawati Veni , Rofiâ€™ah Siti , Makrifah Istina Atul 
Published: February 2023

Dalam pelaksanaan penelitian ini bertujuan untuk mengembangkan teknik dasar passing dan controlling bagi pemain di team Rea Reo Fc Kota Blitar. Penelitian ini di latar belakangi dari hasil observasi sekaligus wawancara yang di lakukan oleh peneliti pada pelatih dan pemain di team Rea Reo Fc Kota Blitar. Peneliti menemukan bahwa terdapat permasalahan yang terjadi yaitu kurang efektifnya Teknik Dasar Â Passing dan Controlling pada antar individu di team ini, hal itu disebabkan karena pelatih hanya menggunakan teknik dasar yang sama seperti yang dahulu, sehingga terkesan monoton daan itu â€“ itu saja. Mengakibatkan pemain menjadi kurang bersemangat dengan desain yang lama ini. Pelaksanaan penelitian dengan model penelitian Borg and Gall. Adapun instrumen yang digunakan peneliti untuk mengumpulkan data berikut : (1) Angket Validasi Instrumen, (2) Angket Validasi Ahli Sepakbola, (3) Angket Respon Pemain . Tujuan penelitian ini untuk meningkatkan kemampuan individu pemain dalam Teknik DasarPassing dan Controlling. Hasil penelitian ini menunjukan bahwa hasilpenilaian dari ahli Validitas Instrumen mendapatkan skor 80%, Ahli Sepakbola mendapatkan skor (1) 94%, (2) 90%, Angket respon pemain setelah penerapan 90%. Bedasarkan hasil observasi pelatih dan pemainÂ saat penerapan desain latihan , juga menunjukan adanya kegiatan timbal balik yang baik antara pemain dan pelatih.Â Desain Latihan Teknik Dasar Passing dan Kontrol pada SepakbolaÂ Abstract: In the implementation of this research,the aim is todevelop basic passing and controlling techniques in the Rea Rea Fc team in Blitar City. This research is based on the results of observations as well as interviews conducted by researchers on coaches and players in the Rea Reo Fc team in Blitar City. The researcher found that there were problems that occurred, namely the ineffectiveness of the Basic Passing and Controlling Techniques between individuals in this team, this was because the trainer only used the same basic techniques as before, so it seemed monotonous and that's all. Resulted in players becoming less excited with this old design. The implementation of the research using the Borg and Gall research model. The instruments used by researchers to collect the following data: (1) Instrument Validation Questionnaire, (2) Football Expert Validation Questionnaire, (3) Player Response Questionnaire. The purpose of this study is to improve the individual skills of players in Basic Passing and Controlling Techniques. The results of this study indicate that the results of the assessment of Instrument Validity experts get a score of 80%, Football Experts get a score of (1) 94%, (2) 90%, Questionnaire player responses after the application of 90%. Based on the results of observations of coaches and players when implementing the exercise design, it also shows that there is a good reciprocal activity between players and coaches.
Tuntutan fisik dan karakteristik kinerja pemain sepakbola berdasarkan posisi bermain
Authors: Sumarno Sumarno , Ristiawan Bayu 
Published: February 2023

Sepakbola sebagai olahraga tim sekaligus permainan yang kompleks membutuhkan kemampuan taktis, teknis, dan fisik tingkat tinggi untuk berhasil. Selama pertandingan kompetitif, kombinasi acak dari aktivitas eksplosif dan kuat, bersama dengan gerakan teknis dan taktis, dilakukan secara berselang selama 90 menit. Tujuan dari penulisan ini untuk mendiskusikan tuntutan fisik dan karakteristik dari permainan sepakbola.Â Penulisan artikel ini menggunakan teknik review literatur yang berfokus pada tuntutan fisik dan karakteristik kinerja pemain sepakbola yang secara khusus menyajikan perbedaannya pada masing-masing posisi bermain pada sepakbola tingkat elit. Hasil dari pembahasan ini adalah permainan sepakbola didominasi oleh sistem energi anaerobik yang mencirikan aktivitas intermiten dengan intensitas tinggi. Pada peran pada masing-masing posisi, secara spesifik pemain memiliki tuntutan fisik yang berbeda. Kami menyimpulkan bahwa untuk melakukan analisis performa pemain sepakbola harus memperhatikan masing-masing posisi bermain.Â Physical demands and performance characteristics of football players according to playing positionÂ Abstract: Football, as a team sport as well as a complicated game, requires high levels of tactical, technical, and physical skills to achieve. During competitive matches, random combinations of explosive and powerful activities and technical and tactical moves are performed intermittently over 90 minutes. The purpose of this paper is to discuss the physical demands and characteristics of the game of football. Writing of this article uses a literature review technique that focuses on the physical demands and performance characteristics of football players, which specifically presents the differences in each playing position in elite-level football. The result of this discussion is that football is dominated by an anaerobic energy system that characterizes intermittent activity with high intensity. In the role of each position, players have different physical demands. We conclude that in order to analyze football players' performance, they need to pay attention to each playing position.
Contributions of the Future Eurocode for the Assessment of Existing Concrete Structures
Authors: Díaz-Pavón Eduardo , Rodríguez Raúl , Ley Jorge , López Pedro 
Published: February 2023

This article highlights the most relevant aspects of the new generation of Eurocodes for the assessment of existing structures, and in particular those governing concrete structures. In this respect, Eurocode 0 will include a new section (prEN 1990-2. Basis of assessment and retrofitting of existing structures: general rules and actions) covering the approach and analysis that must be included in this type of assessment, while Eurocode 2 (prEN1992-1-1:2021 Design of concrete structures) includes Annex I: Assessment of existing structures, which is informative and covers particular aspects of the assessment of concrete structures.
The Origins and Some Highlights on the New Proposal for Eurocode 2
Authors: Arrieta José María , Rodríguez Jesús , Ganz Hans 
Published: February 2023

This paper presents a summary of the procedures for elaborating the Eurocodes that started in the last two decades of the 20th century with some emphasis in the Eurocode 2 on concrete structures. Besides, a general scope of the technical content of new proposal for Eurocode 2 is commented and the main changes are highlighted.
Analisis Jaringan Intranet Di Universitas Flores Menggunakan Quality Of Service (QoS)
Authors: Witi Ferdinandus Lidang , Mude Anastasia 
Published: February 2023

Universitas Flores memanfaatkan fasilitas intranet untuk melaksanakan seluruh kegiatan baik dibidang pendidikan dan pengajaran, kegiatan administrasi akademik dan kemahasiswaan, maupun disemua bidang yang mendukung terlaksananya kegiatan tridarma perguruan tinggi. Jaringan intranet yang ada di Universitas Flores mengalami peningkatan dari tahun ke tahun, dan di tahun 2018 Universitas Flores kembali meningkatkan layanan jaringan intranet menggunakan Cloud Router Switch dengan Virtual Local Area Network. Universitas Flores juga menyediakan layanan hotspot dan wifi di beberapa titik strategi untuk memudahkan seluruh kegiatan akademik. Metode yang digunakan metode action research dengan model sistem monitoring QoS. Software untuk menguji parameter QoS adalah Axence Nettools. Hasil pengolahan data ditampilkan dalam bentuk tabel untuk memudahkan user dalam menganalisis. Dari hasil penelitian disimpulkan bahwa kualitas layanan jaringan intranet di gedung rektorat merupakan kualitas layanan intranet terbaik dengan nilai throughput terbesar yaitu 80,006%, nilai Packet Loss 0% dan nilai Jitter 0%.
Effects of different preservation on the mechanical properties of cortical bone under quasi-static and dynamic compression
Authors: Qiu Jinlong , Liao Zhikang , Xiang Hongyi , Li Haocheng , Yuan Danfeng , Jiang Chengyue , Xie Jingru , Qin Mingxin , Li Kui , Zhao Hui 
Published: February 2023

Introduction: Mechanical properties of biological tissue are important for numerical simulations. Preservative treatments are necessary for disinfection and long-term storage when conducting biomechanical experimentation on materials. However, few studies have been focused on the effect of preservation on the mechanical properties of bone in a wide strain rate. The purpose of this study was to evaluate the influence of formalin and dehydration on the intrinsic mechanical properties of cortical bone from quasi-static to dynamic compression.Methods: Cube specimens were prepared from pig femur and divided into three groups (fresh, formalin, and dehydration). All samples underwent static and dynamic compression at a strain rate from 10−3 s−1 to 103 s−1. The ultimate stress, ultimate strain, elastic modulus, and strain-rate sensitivity exponent were calculated. A one-way ANOVA test was performed to determine if the preservation method showed significant differences in mechanical properties under at different strain rates. The morphology of the macroscopic and microscopic structure of bones was observed.Results: The results show that ultimate stress and ultimate strain increased as the strain rate increased, while the elastic modulus decreased. Formalin fixation and dehydration did not affect elastic modulus significantly whereas significantly increased the ultimate strain and ultimate stress. The strain-rate sensitivity exponent was the highest in the fresh group, followed by the formalin group and dehydration group. Different fracture mechanisms were observed on the fractured surface, with fresh and preserved bone tending to fracture along the oblique direction, and dried bone tending to fracture along the axial direction.Discussion: In conclusion, preservation with both formalin and dehydration showed an influence on mechanical properties. The influence of the preservation method on material properties should be fully considered in developing a numerical simulation model, especially for high strain rate simulation.
Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels
Authors: Marchini Amanda , Ciulla Maria Gessica , Antonioli Barbara , Agnoli Alessandro , Bovio Umberto , Visnoviz Virginia , Bertuzzi Federico , Gelain Fabrizio 
Published: February 2023

Human pancreatic islets transplantation is an experimental therapeutic treatment for Type I Diabetes. Limited islets lifespan in culture remains the main drawback, due to the absence of native extracellular matrix as mechanical support after their enzymatic and mechanical isolation procedure. Extending the limited islets lifespan by creating a long-term in vitro culture remains a challenge. In this study, three biomimetic self-assembling peptides were proposed as potential candidates to recreate in vitro a pancreatic extracellular matrix, with the aim to mechanically and biologically support human pancreatic islets, by creating a three-dimensional culture system. The embedded human islets were analyzed for morphology and functionality in long-term cultures (14-and 28-days), by evaluating β-cells content, endocrine component, and extracellular matrix constituents. The three-dimensional support provided by HYDROSAP scaffold, and cultured into MIAMI medium, displayed a preserved islets functionality, a maintained rounded islets morphology and an invariable islets diameter up to 4 weeks, with results analogues to freshly-isolated islets. In vivo efficacy studies of the in vitro 3D cell culture system are ongoing; however, preliminary data suggest that human pancreatic islets pre-cultured for 2 weeks in HYDROSAP hydrogels and transplanted under subrenal capsule may restore normoglycemia in diabetic mice. Therefore, engineered self-assembling peptide scaffolds may provide a useful platform for long-term maintenance and preservation of functional human pancreatic islets in vitro.
Bioactive cellulose acetate nanofiber loaded with annatto support skeletal muscle cell attachment and proliferation
Authors: Santos Ana Elisa Antunes dos , Cotta Tiago , Santos João Paulo Ferreira , Camargos Juliana Sofia Fonseca , Carmo Ana Carolina Correia do , Alcântara Erika Gabriele Alves , Fleck Claudia , Copola Aline Gonçalves Lio , Nogueira Júlia Meireles , Silva Gerluza Aparecida Borges , Andrade Luciana de Oliveira , Ferreira Roberta Viana , Jorge Erika Cristina 
Published: February 2023

Electrospinning emerged as a promising technique to produce scaffolds for cultivated meat in function of its simplicity, versatility, cost-effectiveness, and scalability. Cellulose acetate (CA) is a biocompatible and low-cost material that support cell adhesion and proliferation. Here we investigated CA nanofibers, associated or not with a bioactive annatto extract (CA@A), a food-dye, as potential scaffolds for cultivated meat and muscle tissue engineering. The obtained CA nanofibers were evaluated concerning its physicochemical, morphological, mechanical and biological traits. UV-vis spectroscopy and contact angle measurements confirmed the annatto extract incorporation into the CA nanofibers and the surface wettability of both scaffolds, respectively. SEM images revealed that the scaffolds are porous, containing fibers with no specific alignment. Compared with the pure CA nanofibers, CA@A nanofibers showed increased fiber diameter (420 ± 212 nm vs. 284 ± 130 nm). Mechanical properties revealed that the annatto extract induces a reduction of the stiffness of the scaffold. Molecular analyses revealed that while CA scaffold favored C2C12 myoblast differentiation, the annatto-loaded CA scaffold favored a proliferative state of these cells. These results suggest that the combination of cellulose acetate fibers loaded with annatto extract may be an interesting economical alternative for support long-term muscle cells culture with potential application as scaffold for cultivated meat and muscle tissue engineering.
ROS production in response to high-power microwave pulses induces p53 activation and DNA damage in brain cells: Radiosensitivity and biological dosimetry evaluation
Authors: Rana Juie Nahushkumar , Mumtaz Sohail , Choi Eun Ha , Han Ihn 
Published: February 2023

Background: Pulsed high-power microwave (HPM) has many applications and is constantly being researched to expand its uses in the future. As the number of applications grows, the biological effects and safety level of pulsed HPM become a serious issue, requiring further research.Objective: The brain is regarded as the most vulnerable organ to radiation, raising concerns about determining an acceptable level of exposure. The effect of nanosecond pulses and the mechanisms underlying HPM on the brain has not been studied. For the first time, we observed the effect of pulsed 3.5 GHz HPM on brain normal astrocytes and cancer U87 MG cells, as well as the likely mechanisms involved.Methods: To generate 3.5 GHz HPM, an axial virtual cathode oscillator was constructed on pulsed power generator “Chundoong”. The cells were directly exposed to HPM (10, 25, 40, and 60) pulses (1 mJ/pulse), with each pulse delivered after 1 min of charging time to evaluate the dose dependent effects.Results: A strong electric field (∼23 kV/cm) of HPM irradiation primarily causes the production of reactive oxygen species (ROS), altering cell viability, mitochondrial activity, and cell death rates in U87 and astrocytes at certain dosages. The ROS generation in response to HPM exposure was primarily responsible for DNA damage and p53 activation. The hazardous dosage of 60 pulses is acknowledged as having damaging effects on brain normal cells. Interestingly, the particular 25 pulses exhibited therapeutic effects on U87 cells via p53, Bax, and Caspase-3 activation.Conclusion: HPM pulses induced apoptosis-related events such as ROS burst and increased oxidative DNA damage at higher dosages in normal cells and specific 25 pulses in cancer U87. These findings are useful to understand the physiological mechanisms driving HPM-induced cell death, as well as the safety threshold range for HPM exposure on normal cells and therapeutic effects on cancer U87. As HPM technology advances, we believe this study is timely and will benefit humanity and future research.
Science, fiction, and Santa Claus: Hollywood creator and consultant perceptions of fictional science in film and television
Authors: Davis Jessica L. , Savoie Gianna , Longnecker Nancy 
Published: February 2023

IntroductionFrom the high-stakes operating room of a Seattle hospital, to the shattered remains of a planet in a galaxy far, far away, Hollywood is often critiqued for its representations of scientific knowledge, methods, and/or technology. Existing research into Hollywood representations of science focuses primarily on those that do not align with expert consensus, and on how audiences engage with these representations — such as how misinformation in fictional narratives influences us. This paper, instead, approaches the matter of fictional science in fictional narratives (FiSci) from the perspectives of the individuals creating Hollywood content. We use the label of “FiSci” for any representation of science within a narrative which does not align with humanity's current knowledge or technological capability.MethodsSemi-structured interviews were conducted in late 2020 with a purposefully-selected sample of both Hollywood creators (writers, directors, and producers; n = 28) and science experts who have served as consultants (n = 18) across a range of film and television projects. Thematic analysis was used to explore how these creators and consultants perceive FiSci and its role within Hollywood narratives. Three themes were constructed from the interview data.Results and discussionParticipants primarily spoke of FiSci as: (1) a storytelling tool, perceived either positively or negatively, depending upon how that tool is wielded; (2) a way to play within a constructed storyworld which does not resemble our own; and (3) a source of unrealistic “B.S.” which threatens to break audience suspension of disbelief and can signify a lack of effort in the creative process. This paper contributes to science communication research by providing access to minds behind the representations of science in Hollywood film and television. As such, it can be used to aid the creator-consultant relationship and the implementation of FiSci to the benefit of both groups. It may also inform creators who have yet to work with a consultant, experts looking to become consultants, audiences critiquing FiSci in the content they watch, and experts and science communicators who express concerns about the use of FiSci and the responsibilities of Hollywood.
Prognostic value of forward flow indices in primary mitral regurgitation due to mitral valve prolapse
Authors: Petolat Elisabeth , Theron Alexis , Resseguier Noemie , Fabre Cyprien , Norscini Giulia , Badaoui Rita , Habib Gilbert , Collart Frederic , Zaffran Stéphane , Porto Alizée , Avierinos Jean-François 
Published: February 2023

BackgroundDegenerative mitral regurgitation (DMR) due to mitral valve prolapse (MVP) is a common valve disease associated with significant morbidity and mortality. Timing for surgery is debated for asymptomatic patients without Class I indication, prompting the search for novel parameters of early left ventricular (LV) systolic dysfunction.AimsTo evaluate the prognostic impact of preoperative forward flow indices on the occurrence of post-operative LV systolic dysfunction.MethodsWe retrospectively included all consecutive patients with severe DMR due to MVP who underwent mitral valve repair between 2014 and 2019. LVOTTVI, forward stroke volume index, and forward LVEF were assessed as potential risk factors for LVEF &lt;50% at 6 months post-operatively.ResultsA total of 198 patients were included: 154 patients (78%) were asymptomatic, and 46 patients (23%) had hypertension. The mean preoperative LVEF was 69 ± 9%. 35 patients (18%) had LVEF ≤ 60%, and 61 patients (31%) had LVESD ≥40 mm. The mean post-operative LVEF was 59 ± 9%, and 21 patients (11%) had post-operative LVEF&lt;50%. Based on multivariable analysis, LVOTTVI was the strongest independent predictor of post-operative LV dysfunction after adjustment for age, sex, symptoms, LVEF, LV end systolic diameter, atrial fibrillation and left atrial volume index (0.75 [0.62–0.91], p &lt; 0.01). The best sensitivity (81%) and specificity (63%) was obtained with LVOTTVI ≤15 cm based on ROC curve analysis.ConclusionLVOTTVI represents an independent marker of myocardial performance impairment in the presence of severe DMR. LVOTTVI could be an earlier marker than traditional echo parameters and aids in the optimization of the timing of surgery.