bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of anterior and posterior segment ocular manifestations in sickle cell disease: A cross-sectional study in western Odisha
Authors: Khuntia Ipsita , Behera Sharmistha , Sahu Sasmita , Baa Jeneeta , Sahoo Mahesh , Nanda Prangnya 
Published: February 2025

: This study investigates the anterior and posterior segment ocular manifestations in sickle cell disease (SCD) patients in Western Odisha. Conducted at Veer Surendra Sai Institute of Medical Sciences and Research (VSSIMSAR) from November 2018 to October 2020, the study involved 103 patients (204 eyes). The prevalence, clinical profiles, and demographic associations of ocular manifestations were assessed using advanced clinical and imaging techniques.: The study highlighted a high prevalence of ocular morbidity in SCD patients, including cataract, glaucoma, and various forms of retinopathy. Anterior segment findings revealed conjunctival vessel abnormalities and iris atrophy. Posterior segment findings included retinal vessel tortuosity and proliferative sickle retinopathy (PSR). The analysis underscored clinical diversity, with significant genotype-specific and age-related associations observed among the patients.: Routine ocular screenings and early interventions are crucial to mitigate the risks of severe vision impairment in SCD patients. The use of advanced imaging techniques aids in precise diagnosis, thereby improving clinical outcomes. Public health initiatives that promote awareness and genetic counseling are essential for the effective management of SCD-related ocular manifestations. This study provides critical insights into the ocular health of SCD patients, guiding future research and healthcare strategies to address these complexities comprehensively. By emphasizing the importance of early detection and intervention, the findings aim to reduce the burden of ocular complications in this patient population.
A descriptive study of correlation between micro-coaxial phacoemulsification parameters and post-operative endothelial cell loss in noncomplicated phacoemulsification surgery
Authors: Pandharikar Aishwarya Jayant , Mandlik Hanumant Rangnath , Patil Sakshi Ravikant , Lanje Kamlesh Najukram , Joshi Ajit Kamalakar , Gotekar Rajesh Balkrishna 
Published: February 2025

To study effect of micro-coaxial phacoemulsification on endothelial cell count in noncomplicated cataract surgery. This was a prospective study, conducted on 150 eyes of cataract patients who underwent microcoaxial phacoemulsification. Clear corneal phacoemulsification was performed using Ozil torsional Technique. Phacoemulsification parameters after cataract surgery as well as pre and post-op endothelial cell count was recorded. The study included 150 cases of senile cataract with mean age of 64.5 years, 52% being male and 48% being females. Endothelial cell loss of 65-1675 cells/mm with (P &#60; 0.001) was noted, which was of high statistical significance. The postoperative EC Loss% ranged from 3.63% to 16.42% with a median of 10.24% (4.32% to 14.67%). A significant +ve correlation (p&#60;0.001) was found between the EC Loss% and different phacoemulsification parameters including CDE, tortional time and volume. Also, EC Loss% was significantly correlated with the grade of nuclear sclerosis (P = 0.045).: Higher grades of cataracts require more phacoemulsification power resulting in increased CDE and EC Loss. Increased aspiration time and the use of excessive amounts of irrigating fluid during phacoemulsification also ends with increased endothelial cell damage.
Study of changes in corneal endothelial cell characteristics in dry eye disease
Authors: Gondhali Gayatri R , Math Shadakshari S , Rahul K  
Published: February 2025

Corneal endothelial cells, vital for maintaining transparency and unable to regenerate, compensate for cell loss by enlarging adjacent cells, which leads to increased size and varying morphology with age. This study emphasizes how dry eye affects these cells, stressing the need to address this frequently neglected condition. This cross-sectional study explored alterations in corneal endothelial cell characteristics among 33 individuals with dry eye disease (DED) compared to 33 age- and gender-matched controls, aged between 18 and 78 years. Participants underwent comprehensive ophthalmic evaluations, and various grades of DED were diagnosed using the Ocular Surface Disease Index questionnaire, Tear Meniscus Height measurement, Tear Film Break-Up Time test, Schirmer’s I test, and Lissamine Green staining and endothelium cells were assessed for endothelial cell density (ECD), cell morphology and central corneal thickness (CCT) by specular microscopy. Compared to the control group (57.73±8), the average cell morphology showed significant changes in individuals with moderate DED (52±9) with p=0.0497, and in those with severe DED (49±7) with p=0.004. Additionally, Central Corneal Thickness (CCT) was notably lower in the severe DED group (485±32 µm) with p=0.002 as compared to control group (533±34 µm). The mean ECD was lower in severe DED patients compared to controls, but not statistically significantly. The research found a correlation between DED severity and corneal endothelial cell characteristics. Severe DED leads to significant morphological alterations and reduced CCT. These findings highlight DED's impact on corneal cells, emphasizing early detection and intervention for preserving corneal health and improving intraocular surgery outcomes.
Inteligência Artificial e a Matemática: uma Revisão Sistemática de Literatura sobre Aplicações em Educação e Ensino
Authors: Feitosa Milena Monteiro , Lemos José de Jesus Sousa , Nascimento Louize , Machado Adilson Matheus Borges 
Published: February 2025

A Inteligência Artificial (IA) transcende os limites da ficção científica, tornando-se uma realidade cada vez mais presente em nosso cotidiano. Este trabalho objetiva mapear as aplicações da IA no ensino e aprendizagem da matemática. De forma específica, a pesquisa buscou: investigar quais ferramentas e tecnologias de IA estão sendo utilizadas em contextos educacionais e matemáticos; identificar como a IA pode ser aplicada no ensino de matemática, e o que pode ser alcançado; analisar os questionamentos levantados por pesquisadores e educadores sobre o uso da IA na educação. A pesquisa utilizou revisão sistemática de literatura na base Web of Science (WOS) e seguiu o método Systematic Search Flow (SSF). Foram identificadas as principais aplicações da IA na educação matemática e o crescente interesse acadêmico no tema, evidenciando seu potencial transformador.

Palavras-chave: Inteligência artificial. Educação matemática. Revisão sistemática.
Seguimento do neonato de risco na perspectiva de profissionais, gestores e mães
Authors: Barbosa Ana Paula Denis , Ueno Patricia Harumi , Canedo Mayara Carolina , Marques Fernanda Ribeiro Baptista , Silveira Aline Oliveira , Luizari Marisa Rufino Ferreira , Gaiva Maria Aparecida Munhoz Gaiva , Marcheti Maria Angélica Marcheti 
Published: February 2025

Objetivo: Analisar o seguimento do recém-nascido de risco na perspectiva de profissionais de saúde, gestores e mães, identificando os desafios e as estratégias adotadas para melhorar a assistência continuada. Método: Estudo descritivo de abordagem qualitativa desenvolvido em um hospital de ensino por meio de entrevistas com dois gestores, dois profissionais de saúde e nove mães de neonatos de risco, que foram submetidas à técnica de análise de conteúdo. Resultados: Os participantes reconhecem a importância de um serviço de seguimento bem organizado para os recém-nascidos de risco no hospital; no entanto, este enfrenta barreiras operacionais e de recursos humanos que resultam na descontinuidade do cuidado, como a desorganização e as dificuldades para atender à demanda. Considerações finais: O seguimento do recém-nascido de risco no ambulatório analisado necessita de organização e implementação de fluxos para o ordenamento da atenção e atendimento da demanda, além da articulação com os serviços da rede de atenção à saúde.
The Use of Color T2 Mapping in MRI Examination of Children with Recurrent Patellar Dislocations in the Postoperative Period
Authors: Andronnikov Evgeniy A. , Alekseeva Tatiana V. , Mikhalkina Natalia G. , Syundyukov Ayrat R. , Preobrazhenskaya Elena V. 
Published: February 2025

Background. Patellar instability in childhood and adolescence may be associated with a violation of its tracking, which often leads to the development of recurrent dislocation and rapid progression of degenerative-dystrophic changes in cartilage tissue. The standard protocol of magnetic resonance imaging (MRI) at the initial biochemical stages of cartilage matrix transformation is not effective enough to assess the shape of the patella, the degree of facet development, the state of articular cartilage, and the integrity of the supporting ligaments of the patella. Quantitative relaxation time T2 during cartilage MR mapping is a noninvasive marker of cartilage degeneration, sensitive to biochemical composition and degree of tissue hydration. T2 mapping can complement the study due to its high diagnostic significance in the early stages of arthrosis development.Objective: to assess the condition of patellar articular cartilage after stabilizing arthroscopic surgery for recurrent patellar dislocation in children using MRI with color T2 mapping.Material and methods. The study included 22 adolescents aged 15–17 years (13 boys, 9 girls) with habitual patellar dislocation. All patients underwent stabilizing surgical treatment. Before the operation, clinical tests, X-ray examinations in three projections, ultrasound and computed tomography of knee joints were performed. Knee joint MRI before, on day 3 and 6 months after surgery was supplemented with color mapping of patellar cartilage tissue with calculation of T2 relaxation time.Results. Local areas in the loaded areas of patellar cartilage with an average T2 relaxation time of 35.5 ms before surgery were detected in all patients. On day 3, with the correct position of the patella, the T2 relaxation time increased to 37.8 ms. After 6 months, 86.4% of patients showed a decrease, including in 73.7% of cases – up to 28.6 ms on average.Conclusion. MRI with color T2 mapping makes it possible to assess the restoration of cartilage structure after stabilizing surgical treatment. A slowdown in the processes of chondro-degeneration and a regenerative effect are noted as early as 6 months after surgery.
Radiomics Analysis of Ultrasound Images of Peripheral Nerves in Young Patients with Type 1 Diabetes Mellitus in Comparison with Healthy Controls
Authors: Fomina, Svetlana V. , Samoilova, Iuliia G. , Pleshkov, Maksim O. , Kudlay Dmitry А. , Voronin, Еvgeniy А. , Kachanov, Dmitriy A. , Tolmachev, Ivan V. , Koshmeleva, Marina V. , Trifonova, Ekaterina I. 
Published: February 2025

Background. Early diagnosis of diabetic polyneuropathy in childhood is an urgent healthcare problem. Radiomics analysis of ultrasound images is a promising diagnostic tool for assessing the morphological structure of peripheral nerves in type 1 diabetes mellitus (T1DM).Objective: to evaluate the possibility of using radiomics analysis in the diagnosis of peripheral nerve changes based on ultrasound images in T1DM patients of young age.Material and methods. A total of 126 ultrasound images of peripheral nerves of the upper and lower limbs in T1DM patients aged 10–17 years (n=10) and controls (n=10) (four locations, greyscale mode) were studied.Results. Radiomics analysis revealed differences in the texture of peripheral nerves of the limbs in young T1DM patients when compared with healthy individuals.Conclusion. The method of radiomics analysis is a promising diagnostic tool for assessing changes in peripheral nerves in children and adolescents with T1DM.
Patterns of Neck Main Arteries Morphometry and Echocardiography Data
Authors: Khalilov Maksud А. , Moshkin Andrey S. , Moshkina Lyubov V. 
Published: February 2025

Objective: to compare the objective results of ultrasound imaging of neck main arteries with echocardiography data, to assess the correlation patterns between the morphological characteristics of the structures.Material and methods. A total of 244 volunteers (who had no signs of significant hemodynamic disorders, surgical interventions on the heart and studied vessels) were examined, who underwent ultrasound imaging of the carotid arteries and echocardiography. All studies were performed using a single technique with an assessment of the diameters of common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), vertebral arteries (VA), as well as intima-media complex (IMC). The echographic characteristics of the aortic wall, aortic and mitral valves were considered. The data obtained were grouped and subjected to statistical analysis.Results. Based on the diagnostic data obtained by echocardiography, eight groups were formed: (1) with signs of changes in the aorta; (2) with changes at the level of the aorta and aortic valve; (3) with changes in the aorta and mitral valve; (4) with changes in the aortic and mitral valves; (5) without signs of changes in the aorta, aortic and mitral valves; (6) with changes only in the aortic valve; (7) with changes only in the mitral valve; (8) with changes only at the level of the aortic and mitral valves. When assessing the differences between pairs of groups in cases of diagnosis of structural changes in the aortic walls and valvular heart apparatus, the indicators differed slightly, more often for IMC value. There were differences for ICA diameter when comparing Groups 1 and 4. Morphometric parameters of VA in cases of diagnosed changes did not reflect significant differences. The largest CCA diameter (5.8±0.7 mm) was noted in combination with changes in the aortic wall and heart valves. The smallest CCA diameter (5.0± 0.3) mm was in Group 6. The largest ICA (4.6±0.4 mm) and ECA (3.6±0.4) diameters were with changes in the mitral valve. The smallest ICA diameter (4.1±0.4 mm) was observed with changes only in the aortic walls. The smallest values for ECA and VA diameters were 2.8 mm, combined with changes in the aortic valve only. The most pronounced differences were obtained when comparing data in the absence of significant changes in the aortic walls and heart valves for CCA, VA, and ECA IMC.Conclusion. The presented results expand our understanding of the individual features of neck main arteries, accompanying changes in the aortic walls and valvular apparatus of the heart.
Academic stress in university students: self-perceived levels and modulation in the relationship with pets
Authors: Simón Emilio Jesús Lizarte , Manzano María Jesús Lirola , Gijón Meriem K. , Galván María Carmen , Puerta José Gijón 
Published: February 2025

Abstract

Introduction: Academic stress and its reduction, often associated with early dropout rates, has become a key issue on the agenda of international higher education policies. Purpose: The research presented here addresses this problem through the analysis of the Stress Less. Take my Paws project, a dog-assisted therapy initiative implemented at the University of Granada. Specifically, the study aims to establish baseline academic stress levels in samples from the University of Extremadura (serving as the control group) and the University of Granada (where the Stress Less. Take my Paws program will be applied). Method: With a total sample size of N = 1097 (827 in the control group and 270 in the intervention group), the study administered the STAI (Trait and State Anxiety Inventory), DASS-21, and additional questions about participants' relationships with pet. The results indicate: a) the reliability of the applied tests for anxiety, stress, and depression; b) a normal distribution of scores in both the control and intervention groups (pre-intervention) and the absence of significant differences between the two groups regarding stress levels, anxiety, and depressive symptoms; and c) no significant differences between individuals who regularly interact with dogs and those who do not (significant differences were found between dog owners and owners of other types of pets). Conclusión: The relevance of these findings is discussed, highlighting the homogeneity between the control and intervention groups, which will enable various studies on the impact of the Stress Less. Take my Paws program.
Constructing multicancer risk cohorts using national data from medical helplines and secondary care
Authors: Modarres Hadi , Pipinis Dimitris , Balasubramanian Divya , Chaplin Rupert , Kynoch Scarlett , Manandhar Achut , Thandi Gusimran , Cavilla Rebecca , Hirst-Williams Emma 
Published: February 2025

Abstract

Identification of cohorts at higher risk of cancer can enable earlier diagnosis of the disease, which significantly improves patient outcomes. In this study, we use machine learning to predict cancer diagnosis in the next year. We select nine cancer sites with high incidence of late-stage diagnosis or worsening survival rates, and where there are currently no national screening programmes. We use National Health Service (NHS) data from medical helplines (NHS 111) and secondary care appointments from all hospitals in England. We show that features based on information captured in NHS 111 calls are among the most influential in driving predictions of a future cancer diagnosis. Our predictive models exhibit good discrimination (AUC – 0.78 – SD 0.04), ranging from 0.69 (ovarian cancer) to 0.83 (oesophageal cancer). While our predictive modelling provides patient level risk predictions, our emphasis is on constructing cohorts of patients who may be at risk of cancer rather than individual risk scores. We present an approach of constructing cohorts at higher risk of cancer based on feature importance and considering possible bias in model results. These outputs can be used to develop highly targeted case finding services, which could help increase earlier detection rates and reduce health disparities. This approach is flexible and can be tailored based on the group the intervention targets (i.e. symptomatic or asymptomatic patients) and the data available to those charged with administering the intervention.
Patterns and Predictors of Mental Workload Among Student Nurses: A Latent Profile Analysis
Authors: Gan Yanmei , Liao Tingting , Liu Lingfang , Du Yao , Guo Mingjuan , Li Gaoye 
Published: February 2025

Abstract

Background Intern nursing students are actually facing considerable psychological burdens, which impact their mental well-being and career progression.
Objective This study aimed to investigate the mental workload patterns of intern nursing students and identify the factors that predict these patterns.
Methods A quantitative cross-sectional study was conducted involving 302 intern nursing students from five hospitals in Guangxi, China, between November 1 and December 30, 2024. The analysis of latent profiles was performed using Mplus 8.7 software, while Pearson’s chi-squared test and logistic regression analysis were carried out using SPSS 27.0 software.
Results Three patterns of mental workload of intern nursing students were identified as “low MWL-high self-rated (n=45, 14.9%)”, “moderate MWL (n=152, 50.33%)”, and “high MWL-low self-rated (n=105, 34.77%)”.
Conclusion This study provided novel insights into the mental workload (MWL) patterns among intern nursing students and identified key predictors, including age, internship duration, coping strategies, educational level and monthly income. The findings highlighted the heterogeneity of MWL and provide evidence-based guidance for nursing administrators to identify groups of students with high mental workload and to develop targeted psychological interventions and management strategies.
Thermoring basis for thermo-gated TRPV2
Authors: Wang Guangyu 
Published: February 2025

Abstract

The heat-responses of the homotetrameric thermosensitive transient receptor potential vanilloid (TRPV)1–4 channels are use-dependent. The initial short heat stimulus typically alters the temperature threshold and sensitivity for the subsequent one. The precise underlying structural motifs have not been identified except for TRPV1 and TRPV3. Since the release of lipid from the active vanilloid site is necessary for the initial heat activation of TRPV1 or TRPV3, the 3D cryo-EM structures of apo rat TRPV2 with or without any lipid in different gating states were analyzed using a highly sensitive thermoring model. The results indicated that two lipids in the voltage sensor-like domain and at the vanilloid site needed to be released to achieve theoretically and experimentally matched start and end thresholds and thermosensitivities during the first and second heat sensations. Therefore, this study further elucidated the role of lipids at various sites in the use-dependent heat responses of thermosensitive TRPV1-4 channels.
Effect of rubber particle size and content on the mechanical properties of rubber-clay mixtures solidified by EICP
Authors: Ma Qiang , Li Meng , Zeng Chen , Shu Hang , Xi Lei , Tao Yue 
Published: February 2025

Abstract

Using the EICP technique to solidify rubber and clay mixtures as lightweight backfill is a feasible way to reduce waste tire impacts and boost rubber recycling in geotech engineering. In this study, a comprehensive laboratory investigation, including triaxial compression, oedometer, permeability, and nuclear magnetic resonance (NMR) tests, was conducted on EICP-reinforced rubber particle solidified clay (hereafter referred to as EICP-RC solidified clay) to evaluate the effects of rubber particle content and size on the mechanical behavior of the improved soil under various solidification conditions and to elucidate the solidification mechanism. The results show that although rubber particles inhibits EICP, it significantly enhances the cohesion and internal friction angle of the samples. Additionally, incorporating smaller-sized tire particles facilitated pore filling, resulting in lower compression and swelling indices and reduced permeability coefficients, making these materials suitable for use behind retaining walls and in embankment construction.