bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness of children's developmental problems and sharing of concerns with parents by preschool teachers and childcare workers: The Japanese context
Authors: Honda Hideo , Sasayama Daimei , Niimi Taemi , Shimizu Ayako , Toibana Yuki , Kuge Rie , Takagi Hidetoshi , Nakajima Aya , Sakatsume Reiko , Takahashi Michiko , Heda Takuma , Nitto Yukari , Tsukada Shota , Nishigaki Akiko 
Published: July 2023

AbstractBackgroundThis study aims to determine the extent to which preschool teachers and childcare workers are aware of the presence of developmental problems among children and to what extent they share information with parents about their concerns regarding a child's development or diagnosis of neurodevelopmental disorders (NDDs).MethodsWe wrote to all 924 preschools and childcare centres in Japan's Nagano and Yamanashi prefectures to request participants. We then sent survey forms to the preschools and childcare centres that agreed to cooperate for three grades comprising 3‐, 4‐ and 5‐year‐olds in the school year 2020. We asked the staff member in charge of each child to complete the survey. The survey included questions about the teacher's concerns regarding the possibility of an NDD and whether the matter had been shared with the children's parents.ResultsWe obtained data for 10 354 children from 206 preschools and childcare centres (response rate = 22.3%). Among these children, 457 (4.4%) had an NDD diagnosis that their parents shared with the teachers. However, the teachers of 1274 children (12.3%) had concerns regarding their development but were not informed by the parents about the diagnosis, if any. These 1274 children included 775 (60.8%) cases where the teachers failed to share their concerns with parents because (1) the teachers could not communicate with parents (n = 119), (2) the teachers were not sure if there was a neurodevelopmental problem (n = 360) and (3) the parents were not aware of the problem (n = 296).ConclusionsPreschool teachers and childcare workers had concerns about the development of a substantial proportion of children in their charge. However, teachers and childcare workers did not share their concerns regarding many children's developmental problems with their parents. The findings suggest that there are challenges in information‐sharing between teachers/childcare workers and parents.
Influence of abutment shape on peri‐implant tissue conditions: A randomized clinical trial
Authors: Bernabeu‐Mira Juan Carlos , Peñarrocha‐Diago María , Viña‐Almunia José , Romero‐Gavilán Francisco , Pérez‐Sayans Mario , Peñarrocha‐Oltra David 
Published: July 2023

AbstractObjectiveTo analyze the influence of 3‐mm high abutments with different shapes (cylindrical abutment vs. wide abutment) on marginal bone‐level changes (bone loss and bone remodeling). The influence of abutment shape on implant success, probing pocket depth (PPD), and bleeding on probing (BoP) was studied as secondary objectives.Materials and MethodsPatients with a partially edentulous area requiring fixed dental prostheses by two implants in the posterior mandible or maxilla were included. The implants were 1 mm subcrestally placed, and osseointegration healing was submerged. Three‐mm high abutments with two different shapes were randomly placed in second‐stage surgery: cylindrical abutments (cylindrical group) and wide abutments (wide group). Marginal bone‐level changes were measured using parallelized periapical radiographs at abutment placement, at definitive prosthesis placement, and at 1, 3, 6, and 12 months after loading. PPD and BoP were likewise measured at the control visits.ResultsSixty‐four dental implants in 25 patients were included. Statistically significant differences were found in bone‐level changes. The cylindrical group exhibited less mean marginal bone remodeling (MBR) and marginal bone loss (MBL) than the wide group (p < .05). Moreover, the cylindrical group showed significantly less BoP (p < .05).ConclusionAbutment shape had a significant influence upon marginal bone‐level changes during the first 12 months. Cylindrical abutments caused less MBR and MBL than wide abutments. More clinical studies involving longer follow‐ups and analyzing other abutment modifications are needed to improve our understanding of how abutments can affect peri‐implant tissue stability.
Evaluation of finite high cycle fatigue life of hard steels using the elliptical curve method
Authors: Castro Tiago Lima , Araujo Lucas Carneiro , Pereira Marcos Venicius , Darwish Fathi Aref , da Silva Gabriel Araujo , Araújo José Alexander 
Published: July 2023

AbstractA direct relation where fatigue life
can be determined as a function of macroscopic normal and shear stress amplitudes
and
is established. Using the Carpinteri & Spagnoli (C&S) criterion as a survey tool, elliptical‐level curves in the
domain were revealed and further generalized, providing means to determine
for any given
combination. Predictions obtained through the elliptical curve method (E) were compared with experimental observations, as well as with predictions obtained from adapted versions of popular fatigue criteria, namely, Findley (F), Matake (M), McDiarmid (McD), Susmel & Lazzarin (S&L), C&S, and Papadopoulos (P). The proposed model delivered predictions in fair agreement with experimental observations, and its predictive capability was seen to be the best among all the considered criteria. Finally, a slight bias toward conservativeness was attenuated with the introduction of an adjusting parameter, further improving the predictive capability of the model.
Notes from the taxonomic disaster zone: Evolutionary drivers of intractable species boundaries in an Australian lizard clade (Scincidae: Ctenotus)
Authors: Prates Ivan , Hutchinson Mark N. , Singhal Sonal , Moritz Craig , Rabosky Daniel L. 
Published: July 2023

AbstractGenomic‐scale datasets, sophisticated analytical techniques, and conceptual advances have disproportionately failed to resolve species boundaries in some groups relative to others. To understand the processes that underlie taxonomic intractability, we dissect the speciation history of an Australian lizard clade that arguably represents a “worst‐case” scenario for species delimitation within vertebrates: the Ctenotus inornatus species group, a clade beset with decoupled genetic and phenotypic breaks, uncertain geographic ranges, and parallelism in purportedly diagnostic morphological characters. We sampled hundreds of localities to generate a genomic perspective on population divergence, structure, and admixture. Our results revealed rampant paraphyly of nominate taxa in the group, with lineages that are either morphologically cryptic or polytypic. Isolation‐by‐distance patterns reflect spatially continuous differentiation among certain pairs of putative species, yet genetic and geographic distances are decoupled in other pairs. Comparisons of mitochondrial and nuclear gene trees, tests of nuclear introgression, and historical demographic modelling identified gene flow between divergent candidate species. Levels of admixture are decoupled from phylogenetic relatedness; gene flow is often higher between sympatric species than between parapatric populations of the same species. Such idiosyncratic patterns of introgression contribute to species boundaries that are fuzzy while also varying in fuzziness. Our results suggest that “taxonomic disaster zones” like the C. inornatus species group result from spatial variation in the porosity of species boundaries and the resulting patterns of genetic and phenotypic variation. This study raises questions about the origin and persistence of hybridizing species and highlights the unique insights provided by taxa that have long eluded straightforward taxonomic categorization.
Deformation Decomposition Versus Energy Decomposition for Chemo- and Poro-Mechanics
Authors: Chua Janel , Karimi Mina , Kozlowski Patrick , Massoudi Mehrdad , Narasimhachary Santosh , Kadau Kai , Gazonas George , Dayal Kaushik 
Published: July 2023

Abstract
We briefly compare the structure of two classes of popular models used to describe poro-mechanics and chemo-mechanics, wherein a fluid phase is transported within a solid phase. The multiplicative deformation decomposition has been successfully used to model permanent inelastic shape change in plasticity, solid–solid phase transformation, and thermal expansion, which has motivated its application to poro-mechanics and chemo-mechanics. However, the energetic decomposition provides a more transparent structure and advantages, such as to couple to phase-field fracture, for models of poro-mechanics and chemo-mechanics.
High Precision Trajectory Learning Method Based Improved Dynamic Movement Primitives for Robot Skill Learning
Authors: Zhai Bin , Zhang Enzheng , Li Bingchen , Fang Xiujun 
Published: July 2023

Abstract
In robot skill learning, the higher accuracy of trajectory reproduction, the smaller difference between the trajectory reproduced by the robot and the expected trajectory, and the higher accuracy and reliability of the robot’s task execution. In robot skill learning methods based on dynamic movement primitives, the problems are found that the tail exponential decay of Gaussian kernel function and the number of shape parameters have a great influence on the accuracy of trajectory reproduction, a high precision trajectory learning method is proposed. A novel truncation processing method is proposed to eliminate the impact of tail exponential decay, and the optimization on the number of shape parameters is used to improve the approximation of the local gradient of the target forcing term, which are combined to improve trajectory reproduction accuracy. The principle of the proposed method is described in detail. The simulation and comparison experiments are performed to verify the effectiveness of the proposed method in improving trajectory reproduction accuracy. This paper makes contributions to the field of robot skill trajectory learning and provides a promising method for improving trajectory reproduction accuracy.
Regularities of Hydrochemical Dynamics in a Two-Dimensional Turbulent Flow of Natural Water
Authors: Danilov-Danilyan V. I. , Rosenthal O. M. 
Published: July 2023

Abstract
Variations in the composition and properties of natural waters, which creates numerous difficulties in water use, cannot always be explained by the influence of external forcing such as weathering or leaching of rocks, changes in the phases of the water regime, and other causes. This is especially true for sub-daily and sub-hourly variations in the water quality, which can be caused by complex, previously unknown dynamic hydrochemical processes. Such a conclusion follows from study of the turbidity and pH of natural water measured with increased frequency, the results of which are presented in this work. These results provide evidence about the existence of quasi-cyclic variations in the controlled parameters with different periods, from minute to daily. Study of the observational data allows us to assume that in this case the hydrochemical dynamics is caused by direct and reverse energy cascades in a two-dimensional turbulent flow of natural water, in which the impurity subsystem may be stratified.
Metamorphic P–T–t evolution deciphered from episodic monazite growth in granulites of the Chencai Complex and implications for the Early Paleozoic Orogeny, West Cathaysia terrane, South China
Authors: Xia Yanfei , Wang Lijun , Rayner Nicole , Lin Shoufa , Xiao Wenjiao , Yin Changqing , Qian Jiahui , Liu Huan , Zhao Xilin 
Published: July 2023

Abstract

The Early Paleozoic Orogeny in eastern South China has been highly controversial. It has been alternatively interpreted to have formed in an intra-plate setting driven by far-field tectonic forces or at plate boundaries involving subduction–collision. The West Cathaysia terrane in the core of the orogen is characterized by extensive magmatism, intense deformation and especially high-grade metamorphism. Identifying early Paleozoic high-pressure (HP) metamorphism and establishing a complete P–T–t path from the high-grade metamorphic rocks could help us understand the tectono-thermal evolution process and nature of the Early Paleozoic Orogeny. Here, we present results from a felsic granulite from the Chencai Complex in the northeastern West Cathaysia terrane. Petrographic evidence, mineral compositions and phase equilibria modelling indicate that the granulite underwent a pre-peak HP stage with P–T conditions of 13.3–14.7 kbar/696–718°C and low geothermal gradients of 13–14°C km
−1
, and a peak high-temperature stage with P–T conditions of 9.7–11.0 kbar/785–820°C. A clockwise P–T path involving pre-peak decompressional heating, post-peak near-isothermal decompression and near-isobaric cooling processes was constrained for the HP felsic granulite.
In situ
monazite U–Pb geochronology combined with previous results date these metamorphic processes at
c.
440,
c.
425 and
c.
400 Ma, respectively. Our new metamorphic and geochronological data from the HP felsic granulite support the case that the Early Paleozoic Orogeny was a typical collisional one.
GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner
Authors: Wang Zijing , Zhang Nan , Zhang Miao , Jiang Yao , Ng Aik Seng , Bridges Esther , Zhang Wei , Zeng Xin , Luo Qi , Liang Jiabien , Győrffy Balázs , Hublitz Philip , Liang Zhu , Fischer Roman , Kerr David , Harris Adrian L. , Cai Shijie 
Published: July 2023

Abstract

GTP cyclohydrolase (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis. The catalysis of BH4 biosynthesis is tightly regulated for physiological neurotransmission, inflammation, and vascular tone. Paradoxically, BH4 has emerged as an oncometabolite regulating tumor growth, but the effects on tumor development remain controversial. Here, we found that GCH1 potentiated the growth of triple-negative breast cancer (TNBC) and HER2+ breast cancer and transformed nontumor breast epithelial cells. Independent of BH4 production, GCH1 protein induced epithelial-to-mesenchymal transition by binding to vimentin (Vim), which was mediated by HSP90. Conversely, GCH1 ablation impaired tumor growth, suppressed Vim in TNBC, and inhibited EGFR/ERK signaling while activating the p53 pathway in estrogen receptor–positive tumor cells. GCH1 deficiency increases tumor cell sensitivity to HSP90 inhibition and endocrine treatments. In addition, high GCH1 correlated with poor breast cancer survival. Together, this study reveals an enzyme-independent oncogenic role of GCH1, presenting it as a potential target for therapeutic development.

Significance:
GTP cyclohydrolase functions as an oncogene in breast cancer and binds vimentin to induce epithelial-to-mesenchymal transition independently of its enzyme activity, which confers targetable vulnerabilities for developing breast cancer treatment strategies.
Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer
Authors: Singh Harshabad , Keller Rachel B. , Kapner Kevin S. , Dilly Julien , Raghavan Srivatsan , Yuan Chen , Cohen Elizabeth F. , Tolstorukov Michael , Andrews Elizabeth , Brais Lauren K. , da Silva Annacarolina , Perez Kimberly , Rubinson Douglas A. , Surana Rishi , Giannakis Marios , Ng Kimmie , Clancy Thomas E. , Yurgelun Matthew B. , Schlechter Benjamin L. , Clark Jeffrey W. , Shapiro Geoffrey I. , Rosenthal Michael H. , Hornick Jason L. , Nardi Valentina , Li Yvonne Y. , Gupta Hersh , Cherniack Andrew D. , Meyerson Matthew , Cleary James M. , Nowak Jonathan A. , Wolpin Brian M. , Aguirre Andrew J. 
Published: July 2023

Abstract

Purpose:
Approximately 8% to 10% of pancreatic ductal adenocarcinomas (PDAC) do not harbor mutations in KRAS. Understanding the unique molecular and clinical features of this subset of pancreatic cancer is important to guide patient stratification for clinical trials of molecularly targeted agents.

Experimental Design:
We analyzed a single-institution cohort of 795 exocrine pancreatic cancer cases (including 785 PDAC cases) with a targeted multigene sequencing panel and identified 73 patients (9.2%) with KRAS wild-type (WT) pancreatic cancer.

Results:
Overall, 43.8% (32/73) of KRAS WT cases had evidence of an alternative driver of the MAPK pathway, including BRAF mutations and in-frame deletions and receptor tyrosine kinase fusions. Conversely, 56.2% of cases did not harbor a clear MAPK driver alteration, but 29.3% of these MAPK-negative KRAS WT cases (12/41) demonstrated activating alterations in other oncogenic drivers, such as GNAS, MYC, PIK3CA, and CTNNB1. We demonstrate potent efficacy of pan-RAF and MEK inhibition in patient-derived organoid models carrying BRAF in-frame deletions. Moreover, we demonstrate durable clinical benefit of targeted therapy in a patient harboring a KRAS WT tumor with a ROS1 fusion. Clinically, patients with KRAS WT tumors were significantly younger in age of onset (median age: 62.6 vs. 65.7 years; P = 0.037). SMAD4 mutations were associated with a particularly poor prognosis in KRAS WT cases.

Conclusions:
This study defines the genomic underpinnings of KRAS WT pancreatic cancer and highlights potential therapeutic avenues for future investigation in molecularly directed clinical trials.
See related commentary by Kato et al., p. 4527
Intratumoral IL15 Improves Efficacy of Near-Infrared Photoimmunotherapy
Authors: Fukushima Hiroshi , Furusawa Aki , Kato Takuya , Wakiyama Hiroaki , Takao Seiichiro , Okuyama Shuhei , Choyke Peter L. , Kobayashi Hisataka 
Published: July 2023

Abstract
IL15 is a potent inducer of differentiation and proliferation of CD8+ T and natural killer (NK) cells, making it a promising candidate for cancer immunotherapy. However, limited efficacy of systemic monotherapy utilizing intravenous IL15 suggests the needs for alternative routes of administration or combination treatment with other therapies. Near-infrared photoimmunotherapy (NIR-PIT) is a highly selective anticancer treatment that elicits a massive release of tumor antigens and immunogenic signals. Here, we investigated whether intratumoral IL15 can enhance the effectiveness of cancer cell-targeted NIR-PIT using syngeneic murine tumor models. Intratumoral injection of IL15 was more effective than intraperitoneal IL15 in vivo in suppressing tumor growth and inducing intratumoral immune responses. When the efficacy of CD44-targeted NIR-PIT was compared in vivo between IL15-secreting MC38 (hIL15-MC38) and parental MC38 tumors, the hIL15-MC38/NIR-PIT group showed the best tumor growth inhibition and survival. In addition, the hIL15-MC38/NIR-PIT group showed significant dendritic cell maturation and significant increases in the number and Granzyme B expression of tumor-infiltrating CD8+ T, NK, and natural killer T cells compared with the treated parental line. Furthermore, intratumoral IL15 injection combined with CD44-targeted NIR-PIT showed significant tumor control in MC38 and Pan02-luc tumor models. In bilateral tumor models, CD44-targeted NIR-PIT in hIL15-MC38 tumors significantly suppressed the growth of untreated MC38 tumors, suggesting abscopal effects. Mice that achieved complete response after the combination therapy completely rejected later tumor rechallenge. In conclusion, local IL15 administration synergistically improves the efficacy of cancer cell–targeted NIR-PIT probably by inducing stronger anticancer immunity, indicating its potential as an anticancer treatment strategy.
Being with Donkeys: Insights into the Valuing and Wellbeing of Donkeys in Central Ethiopia
Authors: Geiger Martha , Hockenhull Jo , Buller Henry , Engida Gebre T. , Jemal Kedir M. , Goshu L. , Getachew M. , Banerjee† A. , Burden F. A. , Whay H. R. 
Published: July 2023

Abstract
This paper explores the interwoven lives of donkeys and the people who depend on them for their livelihoods in central Ethiopia. Drawing on data from 12 participatory workshops, insights were elicited into the ways human co-workers value and treat their donkey co-workers. Methodologically, Participatory Rural Appraisal (PRA) and Appreciative Inquiry (AI) techniques were merged to explore the complex and multi-dimensional contributions donkeys make to participants’ lives. Findings reveal working with donkeys can make the difference between destitution and modest survival, but societal perception of donkeys as low-status animals has an impact on their owners’ lives and donkey wellbeing. This research contributes empirical insights on the valuing of donkeys and enables a deepened understanding of human-donkey relations. The combination of PRA and AI in the methodology demonstrates how to formulate a compassionate and empathetic approach for exploring donkey value and wellbeing with marginalized groups.
Effectiveness and safety of high-voltage pulsed radiofrequency to treat patients with primary trigeminal neuralgia: a multicenter, randomized, double-blind, controlled study
Authors: Jia Yitong , Cheng Hao , Shrestha Niti , Ren Hao , Zhao Chunmei , Feng Kunpeng , Luo Fang 
Published: July 2023

Abstract
Background
Trigeminal neuralgia (TN) is a debilitating pain disorder that still lacks an ideal treatment option. Pulsed radiofrequency (PRF), especially with high output voltage, is a novel and minimally invasive technique. PRF is regarded a promising treatment option for TN patients who respond poorly to medical treatment; however, the available evidence still lacks high quality randomized controlled trials (RCTs). Our study aimed to evaluate the long-term (1 year and 2 years) effects and safety of high-voltage PRF in primary TN patients and provide stronger evidence for TN treatment options.

Methods
We performed a multicenter, double-blind, RCT in adults (aged 18–75 years) with primary TN who responded poorly to drug therapy or were unable to tolerate the side effects of drug. Eligible participants were randomly assigned (1:1) to receive either high voltage PRF or nerve block with steroid and local anesthetic drugs. The primary endpoint was the 1-year response rate. This trial has been registered in the clinicaltrials.gov website (registration number: NCT03131466).

Results
One hundred and sixty-two patients were screened for enrollment between April 28th,2017 and September1st, 2019, among whom, 28 were excluded. One hundred and thirty-four participants were randomly assigned to either receive high voltage PRF (n = 67) or nerve block (n = 67). The proportion of patients with a positive response at 1-year after the procedure in the PRF group was significantly higher than that in the nerve block group in the intention-to-treat population (73.1% vs. 32.8%, p < 0.001). There was no difference between groups in the incidence of adverse events.

Conclusions
Our findings support that high voltage PRF could be a preferred interventional choice prior to receiving more invasive surgical treatment or neuro-destructive treatment for TN patients who have poor responses to medical treatment.

Trial registration
Our study has been registered at ClinicalTrials.gov (trial registration number: NCT03131466).