bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood tau‐PT217 contributes to the anesthesia/surgery‐induced delirium‐like behavior in aged mice
Authors: Lu Jing , Liang Feng , Bai Ping , Liu Chenghao , Xu Miao , Sun Zhengwang , Tian Wenjie , Dong Yuanlin , Zhang Yiying , Quan Qimin , Khatri Ashok , Shen Yuan , Marcantonio Edward , Crosby Gregory , Culley Deborah J. , Wang Changning , Yang Guang , Xie Zhongcong 
Published: May 2023

AbstractINTRODUCTIONBlood phosphorylated tau at threonine 217 (tau‐PT217) is a newly established biomarker for Alzheimer's disease and postoperative delirium in patients. However, the mechanisms and consequences of acute changes in blood tau‐PT217 remain largely unknown.METHODSWe investigated the effects of anesthesia/surgery on blood tau‐PT217 in aged mice, and evaluated the associated changes in B cell populations, neuronal excitability in anterior cingulate cortex, and delirium‐like behavior using positron emission tomography imaging, nanoneedle technology, flow cytometry, electrophysiology, and behavioral tests.RESULTSAnesthesia/surgery induced acute increases in blood tau‐PT217 via enhanced generation in the lungs and release from B cells. Tau‐PT217 might cross the blood–brain barrier, increasing neuronal excitability and inducing delirium‐like behavior. B cell transfer and WS635, a mitochondrial function enhancer, mitigated the anesthesia/surgery‐induced changes.DISCUSSIONAcute increases in blood tau‐PT217 may contribute to brain dysfunction and postoperative delirium. Targeting B cells or mitochondrial function may have therapeutic potential for preventing or treating these conditions.
Impact of the failure of initial insertion of a peripheral intravascular catheter on the development of adverse events in patients admitted to the intensive care unit from the emergency room: A post hoc analysis of the AMOR‐VENUS study
Authors: Kishihara Yuki , Yasuda Hideto , Kashiura Masahiro , Moriya Takashi , Shinzato Yutaro , Kotani Yuki , Kondo Natsuki , Sekine Kosuke , Shime Nobuaki , Morikane Keita ,   the AMOR‐VENUS study group
Published: May 2023

AbstractAimTo investigate an association between failure of initial peripheral intravascular catheter (PIVC) insertion and adverse events in patients admitted to the intensive care unit (ICU) from the emergency room (ER).MethodsThis study was a post hoc analysis of the AMOR‐VENUS study, a multicenter cohort study that included 22 institutions and 23 ICUs in Japan between January and March of 2018. Study participants included consecutive adult patients admitted to the ICU with PIVCs inserted in ICU during the study period exclusively from the ER. The primary outcome was adverse events. Adverse events were composite of arterial puncture, hematoma, extravasation, nerve injury, tendon injury, compartment syndrome, pain, redness, bad location, and effusion. Multivariate logistic regression analyses were performed to assess the association between adverse events and the failure of initial PIVC insertion.ResultsIn total, 363 patients and 1121 PIVCs were analyzed. Moreover, 199 catheters failed to insert properly, and 36 patients and 107 catheters experienced adverse events. After performing multivariate logistic regression analysis, there were statistically significant associations in the odds ratio (OR) and 95% confidence interval (CI) for the failure of initial insertion (OR, 1.66 [1.02–2.71]; p = 0.04).ConclusionFailure of initial insertion may be a risk factor for adverse events. We could potentially provide various interventions to avoid failure of initial PIVC insertion. For example, PIVC insertion could be performed by experienced practitioners.
The National Early Warning Score on admission predicts severe disease and in‐hospital mortality of the coronavirus disease 2019 Delta variant: A retrospective cohort study
Authors: Endo Takuro , Khoujah Danya , Motohashi Takako , Shinozaki Tomohiro , Tsushima Kenji , Fujitani Shigeki , Shiga Takashi 
Published: May 2023

AbstractBackgroundClinical risk scores are widely used in emergency medicine, and some studies have evaluated their use in patients with coronavirus disease 2019 (COVID‐19). However, no studies have evaluated their use in patients with the COVID‐19 Delta variant. We aimed to study the performance of four different clinical scores (National Early Warning Score [NEWS], quick Sequential Organ Failure Assessment [qSOFA], Confusion, Respiratory rate, Blood pressure, and Age ≥65 [CRB‐65], and Kanagawa score) in predicting the risk of severe disease (defined as the need for intubation and in‐hospital mortality) in patients with the COVID‐19 Delta variant.MethodsThis was a retrospective cohort study of patients hospitalized with suspected severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Delta variant infection between June 1 and December 31, 2021. The primary outcomes were the sensitivity and specificity of the aforementioned clinical risk scores at admission to predict severe disease. Areas under the receiver operating characteristic curves (AUROCs) were compared between the clinical risk scores and we identified new cut‐off points for all four scores.ResultsA total of 249 adult patients were included, of whom 18 developed severe disease. A NEWS ≥7 at admission predicted severe disease with 72.2% sensitivity and 86.2% specificity. The NEWS (AUROC 0.88) was superior to both the qSOFA (AUROC 0.74) and the CRB‐65 (AUROC 0.67), and there was no significant difference between the NEWS and Kanagawa score (AUROC 0.86).ConclusionThe NEWS at hospital admission predicted the severity of the COVID‐19 Delta variant with high accuracy.
Locally Concentrated Ionic Liquid Electrolytes Enabling Low‐Temperature Lithium Metal Batteries
Authors: Liu Xu , Mariani Alessandro , Diemant Thomas , Dong Xu , Su Po‐Hua , Passerini Stefano 
Published: May 2023

AbstractLithium metal is a promising anode material for next‐generation high‐energy‐density batteries but suffers from low stripping/plating Coulombic efficiency and dendritic growth particularly at sub‐zero temperatures. Herein, a poorly‐flammable, locally concentrated ionic liquid electrolyte with a wide liquidus range extending well below 0 °C is proposed for low‐temperature lithium metal batteries. Its all‐anion Li+ solvation and phase‐nano‐segregation solution structure are sustained at low temperatures, which, together with a solid electrolyte interphase rich in inorganic compounds, enable dendrite‐free operation of lithium metal anodes at −20 °C and 0.5 mA cm−2, with a Coulombic efficiency of 98.9 %. As a result, lithium metal batteries coupling thin lithium metal anodes (4 mAh cm−2) and high‐loading LiNi0.8Co0.15Al0.05O2 cathodes (10 mg cm−2) retain 70 % of the initial capacity after 100 cycles at −20 °C. These results, as a proof of concept, demonstrate the applicability of locally concentrated ionic liquid electrolytes for low‐temperature lithium metal batteries.
Bilayer‐Coating Strategy for Hydrophobic Nanoparticles Providing Colloidal Stability, Functionality, and Surface Protection in Biological Media
Authors: Schroter Alexandra , Arnau del Valle Carla , Marín María J. , Hirsch Thomas 
Published: May 2023

AbstractThe surface chemistry of nanoparticles is a key step on the pathway from particle design towards applications in biologically relevant environments. Here, a bilayer‐based strategy for the surface modification of hydrophobic nanoparticles is introduced that leads to excellent colloidal stability in aqueous environments and good protection against disintegration, while permitting surface functionalization via simple carbodiimide chemistry. We have demonstrated the excellent potential of this strategy using upconversion nanoparticles (UCNPs), initially coated with oleate and therefore dispersible only in organic solvents. The hydrophobic oleate capping is maintained and a bilayer is formed upon addition of excess oleate. The bilayer approach renders protection towards luminescence loss by water quenching, while the incorporation of additional molecules containing amino functions yields colloidal stability and facilitates the introduction of functionality. The biological relevance of the approach was confirmed with the use of two model dyes, a photosensitizer and a nitric oxide (NO) probe that, when attached to the surface of the UCNPs, retained their functionality to produce singlet oxygen and detect intracellular NO, respectively. We present a simple and fast strategy to protect and functionalize inorganic nanoparticles in biological media, which is important for controlled surface engineering of nanosized materials for theranostic applications.
The Evolutionary Pattern of Cocaine and Hyoscyamine Biosynthesis Provides Strategies To Produce Tropane Alkaloids
Authors: Zamar Duchesse‐Lacours , Papon Nicolas , Courdavault Vincent 
Published: May 2023

AbstractCocaine and hyoscyamine are two tropane alkaloids (TA) from Erythroxylaceae and Solanaceae, respectively. These famous compounds possess anticholinergic properties that can be used to treat neuromuscular disorders. While the hyoscyamine biosynthetic pathway has been fully elucidated allowing its de novo synthesis in yeast, the cocaine pathway remained only partially elucidated. Recently, the Huang research group has completed the cocaine biosynthetic route by characterizing its two missing enzymes. This allowed the whole pathway to be transferring into Nicotiana benthamiana to achieve cocaine production. Here, besides highlighting the impact of this discovery, we discuss how TA biosynthesis evolved via the recruitment of two distinct and convergent pathways in Erythroxylaceae and Solanaceae. Finally, while enriching our knowledge on TA biosynthesis, this diversification of the molecular actors involved in cocaine and hyoscyamine biosynthesis opens perspectives in metabolic engineering by exploring enzyme biochemical plasticity that can ease and shorten TA pathway reconstitution in heterologous organisms.
Chemotherapy resistant Burkitt lymphoma: Possible novel therapies including CAR‐T cell infusion
Authors: Geerts Paulus A. F. , ’t Hart Nils , Visser Otto , Ortiz‐Maldonado Valentín , Chamuleau Martine E. D. 
Published: May 2023

Key Clinical MessageThe prognosis of patients with relapsed or refractory (R/R) BL is poor with limited response to salvage therapy, especially for patients with early relapse (<6 months) or refractory disease. Novel therapies may be promising but need refinement.AbstractThe prognosis of patients with relapsed or refractory (R/R) BL is poor with a limited response to salvage therapy, especially for patients with early relapse (<6 months) or refractory disease. We present three cases of patients with R/R BL receiving novel therapies followed by a literature review. Amongst others, the patients received inotuzumab ozogamicin, idelalisib, ibrutinib, and CAR‐T cell therapy, however, with limited response. In literature, response to several novel agents is described; however, most promising results are seen with CAR‐T cell therapy. Concluding from case series, sequential CAR‐T cell therapy, targeting multiple B‐cell antigens, seems most promising.
Catalytic N‐H Insertion Reactions with α‐Diazoacetates: An Efficient Method for Enantioselective Amino Acid Synthesis
Authors: Su Yu‐Xuan , Huang Ming‐Yao , Zhu Shou‐Fei 
Published: May 2023

AbstractAs the monomers of proteins, amino acids are critical in chemistry and biology, playing important roles in multiple fields such as synthetic chemistry, medicinal chemistry, and materials chemistry. Unlike proteinogenic amino acids, unnatural amino acids can be difficult to obtain from living organisms and generally are synthesized chemically. Recently, a method involving the asymmetric N−H bond carbene insertion reaction with α‐diazoacetates as the carbene precursor has shown high enantioselectivity and good functional group tolerance, allowing for the facile synthesis of natural and unnatural amino acids and the introduction of new concepts in catalysis.
Covalently Modified MoS2 Bearing a Hamilton‐Type Receptor for Recognizing a Redox‐Active Ferrocene‐Barbiturate Guest via Multiple H‐Bonds
Authors: Sideri Ioanna K. , Stangel Christina , Stergiou Anastasios , Liapi Alexandra , Ojeda‐Galván Hiram Joazet , Quintana Mildred , Tagmatarchis Nikos 
Published: May 2023

AbstractThe covalent modification of the metallic phase of MoS2 with a Hamilton‐type ligand is presented, transforming MoS2 to a recognition platform which is able to embrace barbiturate moieties via hydrogen bonding. The successful hydrogen bonding formation is easily monitored by simple electrochemical assessments, if a ferrocene‐labeled barbiturate analogue is utilized as a proof of concept. Full spectroscopic, thermal, and electron microscopy imaging characterization is provided for the newly formed recognition system, along with valuable insights concerning the electrochemical sensing. The given methodology expands beyond the sensing applications, confidently entering the territory of supramolecular interactions on the surface of 2D transition metal dichalcogenides. The well‐designed host‐guest chemistry presented herein, constitutes a guide and an inspiration for hosting customized‐structured functional building blocks on MoS2 and its relatives via hydrogen bonding, opening up new opportunities regarding potential applications.
Block Copolymer Solid Electrolytes Based on Comb‐Like Poly(ethylene glycol) Plasticized Poly(ionic liquid)s for Lithium‐Ion Batteries†
Authors: Zhao Runtao , Yang Jixing , Wang Bin , Ma Zhe , Pan Li , Li Yuesheng 
Published: May 2023

Comprehensive SummaryElectrolytes based on poly(ionic liquid)s (PILs) have attracted great attention in the fields of next‐generation solid lithium‐ion batteries. However, the low ionic conductivity prevents their practical applications. Herein, we report novel solid electrolytes based on block copolymers composed of PILs and comb‐like poly(ethylene glycol) (PEG), which were synthesized via ring‐opening metathesis polymerization of 3‐(2‐(bicyclo[2.2.1]hept‐5‐en‐2‐yl)ethyl)‐1‐butyl‐1H‐imidazol‐3‐ium bis((trifluoromethyl)sulfonyl) amide and poly(ethylene glycol monomethyl ether) bicyclo[2.2.1]hept‐5‐ene‐2‐carboxylate. Comb‐like PEG acts as plasticizers in block copolymers dominated by PILs to promote the mobility of PILs segments. Effects of the copolymer composition and length of the comb‐like PEG chain on ionic conductivity were investigated. The optimized electrolyte delivers the highest ionic conductivity of 1.5 × 10–5 S·cm–1 at 30 °C, and robust electrochemical stability up to 4.6 V. A solid‐state Li/LiFePO4 cell using the optimized electrolyte demonstrates good cycle performance at 0.2 C with high capacity retention of 92% after 70 cycles at 50 °C.
Synthesis Strategies and Nanoarchitectonics for High‐Performance Transition Metal Dichalcogenide Thin Film Field‐effect Transistors
Authors: Baek Seungho , Kim Suhyeon , Han Sang A , Kim Yong Ho , Kim Sunkook , Kim Jung Ho 
Published: May 2023

AbstractTransition metal dichalcogenides (TMDC) exhibit highly superior electrical properties and are typically obtained through mechanical exfoliation. This method has significant limitations, however, such as patterning issues and non‐uniformity, which hinder their application in integrated circuits as transistors and array pixel displays. To overcome these challenges, various large‐scale deposition methods have been developed. In this review, we introduce five major methods for TMDC deposition: chemical vapor deposition, physical vapor deposition, atomic layer deposition, pulsed laser deposition, and ink‐jet printing. An overview of each method is provided in the following order: surface analysis, electrical characteristics, and limitations of each method are discussed. Furthermore, we present three key strategies for an advanced device fabrication using the discussed deposition methods. By implementing these strategies, we can accelerate the development of highly crystalline and scalable TMDC thin films, which are essential for producing advanced electronic devices with improved performance. Owing to recent technological advancements, TMDC devices have the potential to become the leading material for next‐generation semiconductor devices. These devices can be specifically designed and optimized for innovative applications.
Primary cardiac angiosarcoma initially diagnosed on pericardial fluid cytology with histology and autopsy correlation
Authors: Li Yan , Ahn Yoo Min , Niu Shuang 
Published: May 2023

AbstractPrimary cardiac angiosarcoma is an exceedingly rare high‐grade malignancy of the heart originating from endothelial cells, with a predilection for the right atrium in male. Clinical diagnosis is extremely challenging because of the nonspecific symptoms and radiological findings. Although almost always presenting with massive recurrent pericardial effusions, cardiac angiosarcoma diagnosed based on pericardial fluid has rarely been reported, either due to the paucity of malignant cells or misdiagnosis due to low familiarity/suspicion and lack of proper workup. Unfortunately, patients with this disease often receive definitive diagnosis post‐mortem. We report a case of primary cardiac angiosarcoma initially diagnosed on pericardial fluid. The cytomorphology and immunophenotype of angiosarcoma in fluid, as well as the challenges and practical recommendations in using pericardial fluid cytology for early diagnosis of this deadly disease are discussed.
Nutrient intake and its possible drivers in free‐ranging European brown bears (Ursus arctos arctos)
Authors: De Cuyper Annelies , Strubbe Diederik , Clauss Marcus , Lens Luc , Zedrosser Andreas , Steyaert Sam , Verbist Leen , Janssens Geert P. J. 
Published: May 2023

AbstractThe dietary nutrient profile has metabolic significance and possibly contributes to species' foraging behavior. The brown bear (Ursus arctos) was used as a model species for which dietary ingredient and nutrient concentrations as well as nutrient ratios were determined annually, seasonally and per reproductive class. Brown bears had a vertebrate‐ and ant‐dominated diet in spring and early summer and a berry‐dominated diet in fall, which translated into protein‐rich and carbohydrate‐rich diets, respectively. Fiber concentrations appeared constant over time and averaged at 25% of dry matter intake. Dietary ingredient proportions differed between reproductive classes; however, these differences did not translate into a difference in dietary nutrient concentrations, suggesting that bears manage to maintain similar nutrient profiles with selection of different ingredients. In terms of nutrient ratios, the dietary protein to non‐protein ratio, considered optimal at around 0.2 (on metabolizable energy basis), averaged around 0.2 in this study in fall and around 0.8 in spring and summer. We introduced the minimal non‐fat to fat ratio necessary for efficient maintenance metabolism. This ratio varied across seasons but never fell beneath the theoretically estimated minimum to ensure metabolic efficiency. This population thus managed to ingest diets that never exerted a lack of glucogenic substrate, suggesting that metabolic efficiency may either be a driver of active diet selection or that natural resources available to bears did not constitute a constraint in this respect. Given the considerable proportion of fiber in the diet of brown bears, the relevance of this nutrient and its role in foraging behavior might be underestimated.
Mechanochemical Desymmetrization of Unbiased Bis‐ and Tris‐alkynes to Access 3,5‐Isoxazoles‐Alkyne Adducts and Unsymmetrical Bis‐3,5‐isoxazoles**
Authors: Hernandez Rafael A. , Trakakis Irini , Do Jean‐Louis , Cuccia Louis A. , Friščić Tomislav , Forgione Pat 
Published: May 2023

AbstractA mechanochemical desymmetrization of symmetrical bis‐ and tris‐alkynes by a controlled 1,3‐dipolar cycloaddition reaction using nitrile oxide dipoles (NOs). This operationally simple protocol allows access to 3,5‐isoxazole‐alkyne adducts from easily prepared or commercially available symmetrical bis‐ and tris‐alkynes in moderate to excellent yields. In addition, we have highlighted the synthetic utility of 3,5‐isoxazole‐alkyne by developing a route to access, for the first time, β‐ketoenamine‐alkyne derivatives, and unsymmetrical bis‐3,5‐isoxazoles.
Characteristics of digital artifacts in international endeavors of digital‐basedinternational new ventures
Authors: Ojala Arto , Fraccastoro Sara , Gabrielsson Mika 
Published: May 2023

AbstractResearch SummaryCurrent research on digital artifacts and international business reveals that digitalization is changing how firms enter international markets and operate within them. The unbounded nature of digital artifacts provides opportunities for entrepreneur‐driven firms to rapidly launch and develop digital platforms for international markets. However, extant literature provides little guidance on leveraging the specific characteristics of digital artifacts and what entrepreneurs should do to facilitate internationalization. We conducted an extensive longitudinal case study spanning more than 10 years to garner data on digital‐based INV pursuing internationalization. We aimed to conceptualize a theoretical model explaining the role of entrepreneurs in integrating, building, and reconfiguring their capabilities to leverage the characteristics of digital artifacts for platform development.Managerial SummaryWhat actions should entrepreneurs take to leverage the characteristics of digital artifacts to support their firm's internationalization? This study offers entrepreneurs a model to pinpoint those actions and possible avenues for digital platform development in the international market context. The model demonstrates how firms can apply digital artifact characteristics during the phases of internationalization and how those characteristics can facilitate and accelerate the international development of a digital platform. The findings also reveal how different entrepreneurial resources and capabilities should be integrated, built, and reconfigured throughout the process.
To stand out or fit in? How perceived overqualification motivates proactive and affiliative performance
Authors: Ma Chao , Ganegoda Deshani B. , Chen (George) Zhen Xiong , Zhao Jun , Jiang Xinhui , Zhang Xue 
Published: May 2023

AbstractContributing to the literature on positive effects of overqualification, this research examines when and why perceived overqualification predicts affiliative and proactive performance at work. Integrating optimal distinctiveness theory with self‐construal theory, we propose that depending on the nature of an employee's self‐construal (i.e., independent, or interdependent), perceived overqualification will be associated with two opposing motivational processes—namely, differentiation and assimilation. We expect perceived overqualification to have a positive relationship with a motive for assimilation when an employee has a strong interdependent self‐construal. Conversely, we expect perceived overqualification to have a positive relationship with a motive for differentiation when an employee has a strong independent self‐construal. We further argue that assimilation‐seeking and differentiation‐seeking motives will be positively related to affiliative and proactive performance, respectively. We conducted two multi‐waved and multisourced studies to test our hypotheses. In a pilot study (N = 249), we first tested our moderation hypothesis. In our main study (N = 496), we tested our overall moderated mediation model. Results from both studies reveal that perceived overqualification can trigger a need for differentiation or assimilation in employees depending on the nature of their self‐construal. The differentiation‐seeking motive was positively related to proactive performance, while the assimilation‐seeking motive was positively related to affiliative performance. Our findings advance overqualification and motivation literatures and provide insights into talent acquisition and management.