bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of Highly Oriented Ultrathin Zirconium Metal‐Organic Framework Membrane from Nanosheets towards Unprecedented Gas Separation
Authors: Sun Yanwei , Yan Jiahui , Gao Yunlei , Ji Taotao , Chen Sixing , Wang Chen , Lu Peng , Li Yanshuo , Liu Yi 
Published: February 2023

AbstractConcurrent regulation of crystallographic orientation and thickness of zirconium metal–organic framework (Zr‐MOF) membranes is challenging but promising for their performance enhancement. In this study, we pioneered the fabrication of uniform triangular‐shaped, 40 nm thick UiO‐66 nanosheet (NS) seeds by employing an anisotropic etching strategy. Through innovating confined counter‐diffusion‐assisted epitaxial growth, highly (111)‐oriented 165 nm‐thick UiO‐66 membrane was prepared. The significant reduction in thickness and diffusion barrier in the framework endowed the membrane with unprecedented CO2permeance (2070 GPU) as well as high CO2/N2selectivity (35.4), which surpassed the performance limits of state‐of‐the‐art polycrystalline MOF membranes. In addition, highly (111)‐oriented 180 nm‐thick NH2‐UiO‐66 membrane showing superb H2/CO2separation performance with H2permeance of 1230 GPU and H2/CO2selectivity of 41.3, was prepared with the above synthetic procedure.
Rhodium(III)‐Catalyzed C‐H/O2 Dual Activation and Macrocyclization: Synthesis and Evaluation of Pyrido[2,1‐a]isoindole Grafted Macrocyclic Inhibitors for Influenza H1N1
Authors: Song Bichao , Guo Xueying , Yang Li , Yu Haiyue , Zong Xinlei , Liu Xiujuan , Wang Hao , Xu Zhongliang , Lin Zhenyang , Yang Weibo 
Published: February 2023

AbstractThe development of environment‐friendly, step economic couplings to generate structurally diverse macrocyclic compounds is highly desirable but poses a marked challenge. Inspired by the C−H oxidation mechanism of cytochromes P450, an unprecedented and practical RhIII‐catalyzed acylmethylation macrocyclization via C−H/O2 dual activation has been developed by us. The process of macrocyclization is facilitated by a synergic coordination from pyridine and ester group. Interestingly, the reaction mode derives from a three‐component coupling which differs from established olefination and alkylation paths. Density functional theory (DFT) calculations and control experiments revealed the mechanism of this unique C−H/O2 dual activation. The newly achieved acylmethylation macrocyclic products and their derivatives showed a potent anti‐H1N1 bioactivity, which may provide an opportunity for the discovery of novel anti‐H1N1 macrocyclic leading compounds.
Knowledge of periconceptional folic acid supplementation and associated factors among pregnant women attending antenatal care at public health facilities in Hawassa, South Ethiopia
Authors: Besho Merga , Kassa Andargachew , Dula Dubale , Fetensa Getahun , Tolossa Tadesse , Wakuma Bizuneh , Regasa Misganu Teshoma 
Published: February 2023

AbstractBackgroundNeural tube closure defect (NTD) such as spinal bifida and anencephaly are serious neurological disabilities that occur when the neural tube does not close completely within 28 days of conception. Even though Folic acid supplementation during and before pregnancy is proved to significantly reduces the risk of NTDs. Currently only 23% of folic acid preventable NTD achieved Worldwide; mainly due to lack of awareness about folic acid supplementation. This study was aimed to assess the knowledge of Folic acid supplementation among pregnant women attending antenatal care at public health facilities in Hawassa Ethiopia.MethodsInstitution based cross‐sectional study was employed among 358 pregnant women attending antenatal care. Data were collected using an interviewer‐administered structured questionnaire and analyzed using SPSS version 22. The knowledge of Folic acid supplementation was assessed using six multiple‐choice questions. The association between the dependent and independent variables were analyzed using Binary Logistic regression model and statistically significant predictors at p‐value <.05 at 95% CI.ResultsThis study indicated that only 7.5% (95% CI, 5.3–10.1) of pregnant women had good knowledge of Folic acid supplementation. The pregnant women who had a history of at least one previous pregnancy loss AOR = 12.64 (95% CI: 4.98, 32.08) and those who had preconception consultation AOR = 11.77 (95% CI: 3.01, 46.07) were more likely to have good knowledge of periconceptional folic acid supplementation as compared to their counterpart.ConclusionsThe knowledge of periconceptional folic acid supplementation among pregnant women was worryingly low in the study area. Alternative and more effective strategies are needed if the population of Ethiopia is to benefit fully from the folic acid prevention of NTDs. Thus, in Ethiopia the future strategies should focus on the possible way to reach the last group through fortification of staple foods with folic acid along with improving women's awareness on folic acid importance in reducing Neural tube defects.
Emerging role of TAK1 in the regulation of skeletal muscle mass
Authors: Roy Anirban , Narkar Vihang A. , Kumar Ashok 
Published: February 2023

AbstractMaintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in the regulation of skeletal muscle mass in adults. TGF‐β‐activated kinase 1 (TAK1) is a key protein, which coordinates the activation of multiple signaling pathways. Recently, it was discovered that TAK1 is essential for the maintenance of skeletal muscle mass and myofiber hypertrophy following mechanical overload. Forced activation of TAK1 in skeletal muscle causes hypertrophy and attenuates denervation‐induced muscle atrophy. TAK1‐mediated signaling in skeletal muscle promotes protein synthesis, redox homeostasis, mitochondrial health, and integrity of neuromuscular junctions. In this article, we have reviewed the role and potential mechanisms through which TAK1 regulates skeletal muscle mass and growth. We have also proposed future areas of research that could be instrumental in exploring TAK1 as therapeutic target for improving muscle mass in various catabolic conditions and diseases.
Health behavior of young patients with ischemic stroke in Estonia: A score of five factors
Authors: Saapar Minni , Vibo Riina , Schneider Siim , Kõrv Liisa , Mallene Sandra , Kõrv Janika 
Published: February 2023

AbstractBackgroundBehavioral risk factors are common among young patients with stroke. This study aimed to compare the health behavior of patients and healthy controls and develop a combined risk score of health behavior.MethodsThe health behavior of patients aged 18–54 years who suffered an ischemic stroke from 2013 to 2020 in Estonia was compared to the Health Behavior among Estonian Adult Population 2014 study sample. We chose five risk factors for comparison: smoking status, body mass index, physical exercise, diet (salt use and vegetable consumption), alcohol intake (quantity and frequency), and composed a summary score.ResultsComparing 342 patients and 1789 controls, daily smoking (49.0% vs. 22.7%), obesity (33.4% vs. 15.9%), low physical activity (< twice/week) (72.2% vs. 60.5%), excessive salt use (8.6% vs. 4.5%), and frequent alcohol use (≥ weekly) (39.9% vs. 34.0%) were more prevalent among patients. The differences in infrequent vegetable consumption (<6 days/week) and excessive alcohol consumption (7 days, >8 units/females, >16 units/males) were not significant. The observed differences were similar for age groups 18–44 years and 45–54 years. The average Health Behavior Stroke Risk Score (0–10) was 4.6 points (CI 4.4–4.8, SD ± 1.97) for patients and 3.5 points (CI 3.4–3.6, SD ± 1.90) for controls.ConclusionsBefore stroke, young patients displayed significantly worse health behavior than the general population. The largest differences were found for smoking and obesity, and a cumulation of risk factors was observed via the HBSR score.
Differential adoption of castration‐resistant prostate cancer treatment across facilities in a national healthcare system
Authors: Caram Megan E. V. , Kumbier Kyle , Burns Jennifer , Sparks Jordan B. , Tsao Phoebe A. , Stensland Kristian D. , Washington Samuel L. , Hollenbeck Brent K. , Shahinian Vahakn , Skolarus Ted A. 
Published: February 2023

AbstractBackgroundOver the past decade, abiraterone and enzalutamide have largely replaced ketoconazole as oral treatments for castration‐resistant prostate cancer (CRPC). We investigated the differential adoption of abiraterone and enzalutamide across facilities in a national healthcare system to understand the impact a facility has on the receipt of these novel therapies.MethodsUsing data from the VA Corporate Data Warehouse, we identified a cohort of men with CRPC who received the most common first‐line therapies: abiraterone, enzalutamide, docetaxel, or ketoconazole between 2010 and 2017. We described variability in the adoption of abiraterone and enzalutamide across facilities by time period (2010–2013 or 2014–2017). We categorized facilities depending on the timing of adoption of abiraterone and enzalutamide relative to other facilities and described facility characteristics associated with early and late adoption.ResultsWe identified 4998 men treated with ketoconazole, docetaxel, abiraterone, or enzalutamide as first‐line CRPC therapy between 2010 and 2017 at 125 national facilities. When limiting the cohort to oral therapies, most patients treated earlier in the study period (2010–2013) received ketoconazole. A dramatic shift was seen by the second half of the study period (2014–2017) with most men treated with first‐line abiraterone (61%). Despite this shift and a new standard of care, some facilities persisted in the widespread use of ketoconazole in the later period, so‐called late adopting facilities. After multivariable adjustment, patients who received treatment at a late adopting facility were more likely receiving care at a lower complexity, rural facility, with less urology and hematology/oncology workforce (all p < 0.01).ConclusionMany facilities persisted in their use of ketoconazole as first‐line CRPC therapy, even when other facilities had adopted the new standard of care abiraterone and enzalutamide. Further work is needed to identify the effect of this late adoption on outcomes important to patients.
Research Progress on Anti‐Inflammatory Mechanisms of Black Ginseng
Authors: Huo Ran , Wang Mengyuan , Wei Xu , Qiu Ye 
Published: February 2023

AbstractIn recent years, black ginseng, a new type of processed ginseng product, has attracted the attention of scholars globally. Ginsenoside and ginseng polysaccharide, the main active substances of black ginseng, have been shown to carry curative effects for many diseases. This article focuses on the mechanism of their action in anti‐inflammatory response, which is mainly divided into three aspects: activation of immune cells to exert immune regulatory response; participation in inflammatory response‐related pathways and regulation of the expression level of inflammatory factors; effect on the metabolic activity of intestinal flora. This study identifies active anti‐inflammatory components and an action mechanism of black ginseng showing multi‐component, multi‐target, and multi‐channel characteristics, providing ideas and a basis for a follow‐up in‐depth study of its specific mechanism.
Heterocyclic Hemipiperazines: Water‐Compatible Peptide‐Derived Photoswitches
Authors: Gödtel Peter , Starrett Jessica , Pianowski Zbigniew L. 
Published: February 2023

AbstractHemipiperazines are a recently discovered class of peptide‐derived molecular photoswitches with high biocompatibility and therapeutic potential. Here, for the first time we describe photochromism of heterocyclic hemipiperazines. They demonstrate long thermal lifetimes, and enlarged band separation between photoisomers. Efficient photoisomerization occurs under aqueous conditions, although with a need for organic co‐solvent. Bidirectional switching with visible light is observed for an extended aromatic system.
Progress of Azametallacyclopentadienes in the New Century
Authors: Lv Ze‐Jie , Liu Wei , Zhang Wen‐Xiong 
Published: February 2023

AbstractAs the key intermediates in metal‐promoted/catalyzed C−C bond coupling reactions of nitriles and alkynes, azametallacyclopentadienes, M(N=CR1−CR2=CR3), are an important class of azametallacycles. Although the first authentic azametallacyclopentadienes were documented in 1986, their chemistry towards solid‐state structures, intrinsic reactivity, and synthetic application was rarely investigated for a long time. At the beginning of this century, seminal works about the applications of azametallacyclopentadienes in the synthesis of heterocycles, including multi‐substituted pyridines, isoquinolines, furans, and pyrroles were reported. Subsequently, a series of new complexes with this motif, namely the Group 4, aluminum, actinide, and rare‐earth azametallacyclopentadienes were isolated and structurally characterized. Among them, the rare‐earth azametallacyclopentadiene expresses high reactivity towards unsaturated molecules, such as nitriles, isocyanides, and Mo(CO)6 to provide novel fused metallacycles. In this Concept, we reviewed the advances in the preparation, reactivity, and synthetic application of azametallacyclopentadienes in the past twenty years.
Detection of Large Genomic RNA via DNAzyme‐Mediated RNA Cleavage and Rolling Circle Amplification: SARS‐CoV‐2 as a Model
Authors: Gu Jimmy , Mathai Amal , Nurmi Connor , White Dawn , Panesar Gurpreet , Yamamura Deborah , Balion Cynthia , Gubbay Jonathan , Mossman Karen , Capretta Alfredo , Salena Bruno J. , Soleymani Leyla , Filipe Carlos D. M. , Brennan John D. , Li Yingfu 
Published: February 2023

AbstractA new method for the detection of genomic RNA combines RNA cleavage by the 10‐23 DNAzyme and use of the cleavage fragments as primers to initiate rolling circle amplification (RCA). 230 different 10‐23 DNAzyme variants were screened to identify those that target accessible RNA sites within the highly structured RNA transcripts of SARS‐CoV‐2. A total of 28 DNAzymes were identified with >20 % cleavage, 5 with >40 % cleavage and one with >60 % in 10 min. The cleavage fragments from these reactions were then screened for coupling to an RCA reaction, leading to the identification of several cleavage fragments that could efficiently initiate RCA. Using a newly developed quasi‐exponential RCA method with a detection limit of 500 aM of RNA, 14 RT‐PCR positive and 15 RT‐PCR negative patient saliva samples were evaluated for SARS‐CoV‐2 genomic RNA, achieving a clinical sensitivity of 86 % and specificity of 100 % for detection of the virus in <2.5 h.
Measuring adherence to inhaled control medication in patients with asthma: Comparison among an asthma app, patient self‐report and physician assessment
Authors: Cachim Afonso , Pereira Ana Margarida , Almeida Rute , Amaral Rita , Alves‐Correia Magna , Vieira‐Marques Pedro , Chaves‐Loureiro Claudia , Ribeiro Carmelita , Cardia Francisca , Gomes Joana , Vidal Carmen , Silva Eurico , Rocha Sara , Rocha Diana , Marques Maria Luís , Páscoa Rosália , Morais Daniela , Cruz Ana Margarida , Santalha Marta , Simões José Augusto , da Silva Sofia , Silva Diana , Gerardo Rita , Todo Bom Filipa , Morete Ana , Vieira Inês , Vieira Pedro , Monteiro Rosário , Raimundo Maria Rosário , Monteiro Luís , Neves Ângela , Santos Carlos , Penas Ana Margarida , Regadas Rita , Marques José Varanda , Rosendo Inês , Aguiar Margarida Abreu , Fernandes Sara , Cardoso Carlos Seiça , Pimenta Filipa , Meireles Patrícia , Gonçalves Mariana , Fonseca João Almeida , Jácome Cristina 
Published: February 2023

AbstractBackgroundPrevious studies have demonstrated the feasibility of using an asthma app to support medication management and adherence but failed to compare with other measures currently used in clinical practice. However, in a clinical setting, any additional adherence measurement must be evaluated in the context of both the patient and physician perspectives so that it can also help improve the process of shared decision making. Thus, we aimed to compare different measures of adherence to asthma control inhalers in clinical practice, namely through an app, patient self‐report and physician assessment.MethodsThis study is a secondary analysis of three prospective multicentre observational studies with patients (≥13 years old) with persistent asthma recruited from 61 primary and secondary care centres in Portugal. Patients were invited to use the InspirerMundi app and register their inhaled medication. Adherence was measured by the app as the number of doses taken divided by the number of doses scheduled each day and two time points were considered for analysis: 1‐week and 1‐month. At baseline, patients and physicians independently assessed adherence to asthma control inhalers during the previous week using a Visual Analogue Scale (VAS 0–100).ResultsA total of 193 patients (72% female; median [P25–P75] age 28 [19–41] years old) were included in the analysis. Adherence measured by the app was lower (1 week: 31 [0–71]%; 1 month: 18 [0–48]%) than patient self‐report (80 [60–95]) and physician assessment (82 [51–94]) (p < 0.001). A negligible non‐significant correlation was found between the app and subjective measurements (ρ 0.118–0.156, p > 0.05). There was a moderate correlation between patient self‐report and physician assessment (ρ = 0.596, p < 0.001).ConclusionsAdherence measured by the app was lower than that reported by the patient or the physician. This was expected as objective measurements are commonly lower than subjective evaluations, which tend to overestimate adherence. Nevertheless, the low adherence measured by the app may also be influenced by the use of the app itself and this needs to be considered in future studies.
Variation in second breast cancer risk after primary invasive cancer by time since primary cancer diagnosis and estrogen receptor status
Authors: Lowry Kathryn P. , Ichikawa Laura , Hubbard Rebecca A. , Buist Diana S. M. , Bowles Erin J. A. , Henderson Louise M. , Kerlikowske Karla , Specht Jennifer M. , Sprague Brian L. , Wernli Karen J. , Lee Janie M. 
Published: February 2023

AbstractBackgroundIn women with previously treated breast cancer, occurrence and timing of second breast cancers have implications for surveillance. The authors examined the timing of second breast cancers by primary cancer estrogen receptor (ER) status in the Breast Cancer Surveillance Consortium.MethodsWomen who were diagnosed with American Joint Commission on Cancer stage I–III breast cancer were identified within six Breast Cancer Surveillance Consortium registries from 2000 to 2017. Characteristics collected at primary breast cancer diagnosis included demographics, ER status, and treatment. Second breast cancer events included subsequent ipsilateral or contralateral breast cancers diagnosed >6 months after primary diagnosis. The authors examined cumulative incidence and second breast cancer rates by primary cancer ER status during 1–5 versus 6–10 years after diagnosis.ResultsAt 10 years, the cumulative second breast cancer incidence was 11.8% (95% confidence interval [CI], 10.7%–13.1%) for women with ER‐negative disease and 7.5% (95% CI, 7.0%–8.0%) for those with ER‐positive disease. Women with ER‐negative cancer had higher second breast cancer rates than those with ER‐positive cancer during the first 5 years of follow‐up (16.0 per 1000 person‐years [PY]; 95% CI, 14.2–17.9 per 1000 PY; vs. 7.8 per 1000 PY; 95% CI, 7.3–8.4 per 1000 PY, respectively). After 5 years, second breast cancer rates were similar for women with ER‐negative versus ER‐positive breast cancer (12.1 per 1000 PY; 95% CI, 9.9–14.7; vs. 9.3 per 1000 PY; 95% CI, 8.4–10.3 per 1000 PY, respectively).ConclusionsER‐negative primary breast cancers are associated with a higher risk of second breast cancers than ER‐positive cancers during the first 5 years after diagnosis. Further study is needed to examine the potential benefit of more intensive surveillance targeting these women in the early postdiagnosis period.
Pharmacokinetics, Safety, and Bioequivalence of 2 Lopinavir/Ritonavir (200/50 mg) Tablets in Healthy Chinese Volunteers: Effect of Food on Absorption
Authors: Zhang Wei , Lin Lili , Fu Wanjin , Bao Dandan , Zhang Qian , Liu Yueyue , Zheng Liang , Hu Wei 
Published: February 2023

AbstractLopinavir/ritonavir is an important protease inhibitor for treating HIV‐1 infection in patients aged >2 years in combination with other antiretrovirals. The antiviral activity of lopinavir/ritonavir in vivo is mainly derived from lopinavir, while ritonavir improves the bioavailability of lopinavir. This study compared the bioequivalence and safety of 2 lopinavir/ritonavir (200/50 mg) formulations under fasted and fed conditions in healthy Chinese volunteers and compared the pharmacokinetic parameters of lopinavir and ritonavir. A randomized, open‐label, single‐dose, 4‐period, crossover bioequivalence was conducted in 72 subjects under fasted and fed conditions. Lopinavir and ritonavir plasma concentrations were analyzed using validated liquid chromatography with tandem mass spectrometry. Noncompartmental analysis was used to evaluate pharmacokinetic parameters. The 90% confidence intervals of test/reference geometric mean ratio for lopinavir and ritonavir area under the plasma concentration–time curve and maximum drug concentration meets the bioequivalence criteria based on the average bioequivalence method. A high‐fat meal delayed the time to the maximum concentration of lopinavir and ritonavir. Therefore, these formulations were bioequivalent in healthy Chinese volunteers under fasting and fed conditions. Moreover, adverse events were more frequent in the fed state, but all were mild.
High‐Valence Metal‐Organic Framework Materials Constructed from Metal‐Oxo Clusters: Opportunities and Challenges
Authors: Wang Chen , Yan Jiahui , Chen Sixing , Liu Yi 
Published: February 2023

AbstractMetal‐organic framework (MOF), which possesses stable framework structure constructed by highly connected metal‐oxo cluster nodes and organic linkers, has shown great promise in gas storage, adsorption, and separation, owing to the high surface areas, tunable pore aperture, and rich functional groups. In this review article, we summarized recent progress made in synthesizing high‐valence MOF (e. g., UiO‐66, MIL‐125, PCN‐22, and MIP‐207) with metal‐oxo cluster as metal source. Of particular note, recent breakthroughs in the preparation of UiO‐66 and MIL‐125 membranes with the corresponding Zr6‐oxo and Ti8‐oxo cluster sources (e. g., Zr6O4(OH)4(OAc)12 and Ti8O8(OOCR)16 clusters) possessing superior separation performance were highlighted. In the end, an outlook on the preparation of versatile high‐valence MOF membranes with the corresponding metal‐oxo clusters as metal sources was highlighted.