bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Skin Autofluorescence with Blood Glucose Levels in Children with Type 1 Diabetes Mellitus
Authors: Deng Tinghan , Wu Jingping , Cheng Hongbin 
Published: August 2023

Abstract
Background
People with diabetes mellitus are particularly vulnerable to chronic glycation of proteins and tissue damage caused by the buildup of advanced glycation end products (AGEs). A non-invasive optical technique called skin autofluorescence (SAF) can be used to detect the accumulation of AGEs in the skin. There is a significant association between elevated SAF and diabetes and it predicts the development of complications associated with diabetes. This study evaluated the correlation between SAF and both status and development and also SAF's possible clinical utility as a tool for detecting type 1 diabetes mellitus (T1DM) and its complications in children.
Methods
A systematic search was conducted across the following databases: PubMed, MEDLINE, EMBASE, Cochrane Central Register of Control Trials, Science Direct, Scopus, and Web of Science. We used a random effects model for FOX analysis to examined the link between AGEs detected through SAF levels and T1DM in children. The SAF values of children with and without T1DM were compared. Analysis of 95% confidence interval correlation coefficients based on DerSimonian and Laird methods was performed for application of SAF measurements as a noninvasive alternative to T1DM diagnosis and complications.
Results
Three case-control studies and one retrospective cohort study were included in the systematic review and meta-analysis. The AGE Reader® (DiagnOptics Technologies, Groningen, The Netherlands) was used to evaluate the SAF of all included studies. The results showed that there was statistically significant heterogeneity among the four studies (I2 = 82.00% P < 0.05). The random effect model showed that higher SAF levels were positively correlated with T1DM in children [0.20 (0.16, 0.25)], which indicated that in the four studies, the SAF value of T1DM children was higher than that of non-type 1 diabetic children.
Conclusion
Our findings suggest that measuring SAF levels may serve as a non-invasive marker for T1DM in children and its associated complications. Nevertheless, to obtain more robust conclusions and support specific data on T1DM complications, further research with a larger population and a longer follow-up duration is necessary.
Evaluation of Rock Burst Tendency in Western Hubei Based on BP Neural Network
Authors: Chai Xiuwei , Sheng Yiming , Zhang Long , Nie Zheng , Zhang Dianji 
Published: August 2023

Abstract

Rock burst tendency evaluation is the basis of rock burst risk assessment in underground engineering. In order to realize the accurate evaluation of rock burst tendency in western Hubei, the four parameters of rock burst strength, uniaxial compressive strength of rock σc, the ratio of uniaxial compressive strength to tensile strength σc/σt, rock mass integrity coefficient Kv, the ratio of tangential stress to uniaxial compressive strength σθ/σc were selected as the evaluation index of rock burst tendency in western Hubei.In order to realize the measurement of the above indexes, the location and phenomenon of the rock burst in western Hubei are summarized, and the rock burst is sampled. Then, through the combination of the field and indoor tests, the measurement of the rock burst tendency evaluation index in western Hubei is completed. Finally, based on the Matlab toolbox, round and rank functions are used to generate random training samples and construct the BP neural network model, and the model was tested. The prediction results show that the rock explosion mainly occurs in dolomite and phosphorus rock, and the evaluation results are consistent with the actual situation. The model is practical and relatively easy to calculate, which reduces the deviation caused by individual influencing factors and is easy to popularize in practice.
Simulating Timeshifting for Long-Running Large Language Models
Authors: Jagannadharao Akshaya , Beckage Nicole , Nafus Dawn , Chamberlin Scott 
Published: August 2023

Abstract
Language models play a vital role in various natural language processing tasks, but their training can be computationally intensive and lead to significant carbon emissions. In this study, we explore the effectiveness of timeshifting strategies to mitigate the environmental impact of long-running language models (LLMs). We develop a simulation tool that estimates carbon emissions for LLMs, enabling developers to make informed decisions before running their workloads. By leveraging historical carbon intensity data from WattTime, we investigate the potential benefits and limitations of time-shifting in different locations, considering diverse energy profiles. Our findings demonstrate that time-shifting can substantially reduce emissions for certain workloads, but it is highly dependent on the region's carbon intensity and energy mix. We present insights into the trade-offs between emissions reduction and workload runtime, acknowledging the need for further advancements in carbon-aware computing practices. Our research contributes to the growing field of sustainable computing and encourages developers to adopt environmentally conscious strategies in language model training.
Origin and spatial population structure of Malagasy native chickens based on mitochondrial DNA
Authors: Yonezawa Takahiro , Mannen Hideyuki , Honma Kaho , Matsunaga Megumi , Rakotondraparany Felix , Ratsoavina Fanomezana Mihaja , Wu Jiaqi , Nishibori Masahide , Yamamoto Yoshio 
Published: August 2023

Abstract
Since Malagasy human culture became established in a multi-layered way by genetic admixture of Austronesian (Indonesia), Bantu (East Africa) and West Asian populations, the Malagasy native livestock should also have originated from these regions. While recent genetic studies revealed that Malagasy native dogs and goats were propagated from Africa, the origin of Malagasy native chickens is still controversial. Here, we conducted a phylogeographic analysis of the native chickens, focusing on the historical relationships among the Indian Ocean rim countries and based on mitochondrial D-loop sequences. Although previous work suggested that the rare Haplogroup D occurs with high frequencies in Island Southeast Asia–Pacific, East Africa and Madagascar, the major mitochondrial lineage in Malagasy populations is actually not Haplogroup D but the Sub-haplogroup C2, which is also observed in East Africa, North Africa, India and West Asia. We demonstrate that the Malagasy native chickens were propagated directly from West Asia (including India and North Africa), and not via East Africa. Furthermore, they display clear genetic differentiation within Madagascar, separated into the Highland and Lowland regions as seen in the human genomic landscape on this island. Our findings provide new insights for better understanding the intercommunion of material/non-material cultures within and around Madagascar.
Design a new unsymmetrical Schiff base chiral Co-complex containing ionic liquid groups as a reusable green catalyst in the epoxidation of alkenes
Authors: mohammadian reza , Sandaroos Reza , Allahresani Ali 
Published: August 2023

Abstract
A chiral magnetic catalyst, L-Co (II) - γ-Fe2O3, was prepared by complexing a chiral Schiff base ligand containing an ionic liquid to cobalt chloride and then stabilizing the complex on γ-Fe2O3 nanoparticles. The catalyst and ligand were characterized using HNMR, CNMR, CHN, EDX, SEM, UV-Vis, ICP, TGA, VSM, FT-IR, and XRD analyses. Excellent catalytic activity and enantioselectivity were observed in the green epoxidation of alkenes in the presence of TBHP and EtOAc solvent. The catalyst with magnetic separation capability was recovered with a slight decrease in conversion and yield of epoxidation after five runs.
Fluid Intake, Fiber Consumption and Physical Activity Related to Constipation among Elderly, Which One Is More Important? A cross sectional study from Iran
Authors: safarnaveh Maryam , ghanbari Mahin , Mahmoodi Zohreh , Salehi leili 
Published: August 2023

Abstract

Background: Chronic constipation is a common, self-reported, symptom-based disorder which can significantly impact an individual’s health-related quality of life [1]. Constipation affects the quality of life of a person with social problems and imposes many financial costs on the person The prevalence of constipation is estimated at 1 to 80% around the worldods: Inadequate fluid consumption is touted as a common culprit in constipation, and increasing fluid intake is a frequently recommended treatment. Evidence suggests, however, that increasing fluids is only of usefulness in individuals in a hypo hydrated state, and is of little utility in EU hydrated individuals".There is a strong association between obesity and constipation . Although obesity is also associated with constipation; it is not recognized as a causal factor of constipation. Another investigation indicated constipation and obesity have common risk factors. However, little is known about constipation in individuals with severe obesity and the associated factors The current study was conducted to investigate the effect of Water consumption, fiber intake, and PA on Constipation and which one is more critical by considering Mediating effect of BMIMethods:The study was a cross-sectional study performed on 400 older adults in 2019 referring to the comprehensive health service centers in Karaj, the capital of Alborz province,several instruments included demographic and antro pometric traits , PASE,fluid intakes, FFQ و WHO Qol, wexner cospitation were used to collect data.ُSPSS and lizrelsoftwares were used to analysize dataResults: Based on the final fitted model, PA is the most critical factor related to constipation compared to fluid intake and fiber consumption. The finding of the present study was in line with several studies.Based on the final fitted model, fiber consumption is the second most factor affecting constipation, and there is a negative association between constipation and fiber intake.Conclusions: As price is one of the barriers to fiber consumption in the elderly, the recommendation to do Physical activity such as walking to solve the problem of constipation is efficient and inexpensive advice for people with different socioeconomic statuses.
Novel fluorimetric procedure for estimation of Sumatriptan in its tablet formulation and in human plasma; Implementation to content symmetry testing
Authors: Alrofaidi Mohamed A. , Omar Mahmoud A. , Abdelmageed Osama H , Alahmadi Yaser M. , Eltoukhi Walid E. 
Published: August 2023

Abstract

A rapid, simple & specific fluorimetric method has been described for estimation of Sumatriptan succinate in its pharmaceutical preparation and in human plasma. The proposed procedure is based on the measurement of the fluorescence intensity of studied drug in sulphuric acid / methanol at 350 nm (λex286 nm). Straight correlation was obtained between the fluorescence intensity and concentrations studied over the concentration range 0.1 -2.0 µg/ml with correlation coefficient of 0.999. The detection and quantitation limits were 0.019 and 0.057 µg/ml, respectively. The suggested procedure was validated according to ICH and USP guidelines. It was applied successfully implemented to the estimation of STS in its tablet formulation and content uniformity testing. The suggested method was sensitive enough to allow the estimation of STS in human plasma.
Patient Engagement in Research Scale (PEIRS-22) - Danish translation, applicability, and user experience among cancer patients and caregivers
Authors: Christiansen Mille Guldager , Pappot Helle , Hamilton Clayon , Lund-Jacobsen Trine , Kristensen Anne Wilhøft , Nordentoft Sara , Høeg Beverley Lim , Bidstrup Pernille , Nielsen Iben Husted , Ulstrup Jane , Trip Anouk Kirsten , Jarden Mary , Piil Karin 
Published: August 2023

Abstract

Background
Patient and Public Involvement (PPI) in health research is gaining increased attention and acceptance worldwide. Reliable measurements are crucial to accurately assess, monitor, and evaluate patient involvement efforts in research. The Patient Engagement in Research Scale (PEIRS-22) measures meaningful patient and family caregiver engagement in research. This study focuses on three primary objectives: 1) translation of the PEIRS-22 from English to Danish, followed by linguistic validation and cultural adaptation; 2) assessing the applicability of the Danish PEIRS-22; and 3) focus group interviews to explore the user experiences of PPI.
Methods
A three-phase multi-method study was conducted. In phase one, the PEIRS-22 was translated, linguistically validated and culturally adapted to Danish. In phase two individuals from three distinct cancer patient advisory boards responded to the Danish version of PEIRS-22 to assess its applicability. Three focus group interviews were conducted in phase three, involving individuals from three patient cancer advisory boards.
Results
The translation process resulted in a Danish version of PEIRS-22, conceptually and culturally equivalent to the English version. Overall, among individuals of the three advisory boards (n=15) the applicability was found to be satisfactory, with no missing data and all items completed. The total PEIRS-22 score among the three advisory boards was 85.2 out of a possible 100, with higher scores indicating greater meaningful involvement. A nested sample of the three patient advisory boards (n=9) participated in focus group interviews. The analysis yielded four themes: 1) The Danish PEIRS-22 accurately captured the intended meaning and cultural nuances, 2) Internal motivation is a driver for involvement 3), Involvement brought a personal sense of empowerment and 4) Meaningful involvement collaborations are fostered by a trustful atmosphere.
Conclusions
The PEIRS-22 questionnaire has been translated, linguistically validated and culturally adapted into Danish. We propose that the PEIRS-22 is now ready for use in Danish populations. This study contributes to advancing patient-centered practices and fosters meaningful involvement and collaborations between patients and researchers in the field of cancer research in Denmark. Personal benefits of participating in PPI can vary, and we recommend using PEIRS-22 in conjunction with a qualitative approach to better explore perspectives on meaningful involvement.
Trial registration: The study was registered prospectively on October 22, 2022, by the Danish Data Protection Agency (jr. nr. P-2022-528)
Oxidative stress accompanies HIF1-dependent impairment of glucose metabolism in the hippocampus of adult rats survived prenatal severe hypoxia
Authors: Vetrovoy Oleg , Stratilov Viktor , Potapova Sofiya , Tyulkova Ekaterina 
Published: August 2023

Abstract
Many socially significant diseases are associated with disorders of prenatal development. Previously, we have shown the pathological role of hypoxia inducible factor HIF1 in post-hypoxic reoxygenation. This study aims to investigate the effect of prenatal severe hypoxia (PSH) on HIF1α protein expression as well as on HIF1-dependent activity of the pentose phosphate pathway (PPP) and anaerobic glycolysis in the hippocampus (HPC) of the offspring reached adulthood. We showed that PSH causes a stable increase in the content of HIF1α protein in the HPC which was accompanied by an increase in the efficacy of anaerobic glycolysis. This was testified by increased LDH activity and lactate concentration. At the same time, the amounts of G6PD, NADPH and also reduced glutathione decreased in the HPC of PSH rats, whereas the concentration of an oxidative stress marker, MDA, exceeded the control values. In a series of experiments using the model of emotional stress "learned helplessness" or the model of severe hypoxic stress, it was shown that in the HPC of control rats there was an increase in the amount of HIF1α in response to stress, which was also accompanied by more efficient anaerobic glycolysis and decreased efficacy of the PPP similar to the intact PSH rats. In the PSH rats, in turn, emotional stress resulted even in higher HIF1α levels without affecting glycolysis and PPP. Therefore, the increased content and activity of the transcription factor HIF1α in the HPC of adult rats exposed to prenatal hypoxia leads to the imbalance between glycolysis and the PPP which is accompanied by oxidative stress.
Dark diversity reinforces the importance of climate, soil and disturbance for Caatinga plant diversity
Authors: Araújo Magno Daniel Oliveira Gonçalves , Carvalho Carlos Eduardo , Pequeno Pedro Aurélio Costa Lima , Trindade Diego Pires Ferraz , Hughes Frederic , Araújo Francisca Soares , Partel Meelis , Sfair Julia Caram 
Published: August 2023

Abstract
Species richness is the most commonly used metric to quantify biodiversity. However, examining dark diversity, the group of absent species which can potentially inhabit a site, can provide insights about the factors influencing species assembly. In this study we aimed to understand how climate, soil, acute, and chronic disturbance factors affect not only observed diversity but also dark diversity, completeness (how large is the observed diversity compared to dark diversity) and species pool size (observed and dark diversity together) patterns of a Seasonally Dry Tropical Forest in Brazil. Along 144 0.4-ha plots for trees and 0.04-ha plots for shrubs, herbs, and lianas, we recorded 2148 stems from 232 native species. In general, rainfall was the major drive of plants diversity, whereas soil fertility, deforestation and chronic anthropogenic disturbance had a minor effect. Dark diversity, completeness, species pool and observed diversity respond differently to the different predictors, indicating the complex biodiversity relationship with environmental and disturbance factors. These results highlight the importance of using different metrics of species richness and considering different groups in plant communities’ studies.
Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson's disease via histone lactylation
Authors: Qin Qixiong , Wang Danlei , Qu Yi , Li Jiangting , An Ke , Mao Zhijuan , Li Jingyi , Xiong Yongjie , Min Zhe , Xue Zheng 
Published: August 2023

Abstract
The metabolic switch from oxidative phosphorylation to glycolysis is a vital hallmark and prerequisite for microglia phenotype transition. Recently, histone lactylation was shown to promote macrophage homeostatic gene expression via transcriptional regulation. However, the role of histone lactylation in regulating microglia function in Parkinson’s disease (PD) remains unclear. Here, we show that glycolytic inhibitor 2-deoxy-D-glucose alleviatesmicrogliosis, neuroinflammation, and dopaminergic neuronal damage by reducing lactate accumulation. Notably, histone lactylation, especially H3K9la, is markedly increased in microglia within the substantia nigra of a mouse model of PD and lipopolysaccharide-stimulated primary microglia. Mechanistically, enhanced glycolysis-derived lactate induces H3K9la enrichment at the promoter of solute carrier family 7 member 11 (Slc7a11), promoting its transcription. Inhibition ofSLC7A11 by sulfasalazine mitigates microglia-mediated neuroinflammation and improves motor function in the mouse model PD mice. Moreover, lactate-induced histone lactylation is dependent on the p300/CBP. Collectively, ourfindings demonstrate that augmented glycolysis-derived lactate promotes microglial activation via histone lactylation and provide a novel therapeutic strategy for PD.
Association of mitral valve geometry at CT with secondary mitral regurgitation after transcatheter aortic valve replacement in patients with aortic regurgitation
Authors: Yin Minyan , Lu Yuntao , Chen Jinmiao , Yang Xue , Dong Lili , Wang Xiaolin , Wei Lai 
Published: August 2023

Abstract
Purpose
To determine predictors of persistent moderate to severe secondary mitral regurgitation in patients with aortic regurgitation after transcatheter aortic valve replacement (TAVR) by mitral valve geometry assessment at CT.
Methods
This retrospective cohort study reviewed 242 consecutive patients with aortic regurgitation who underwent TAVR between May 2014 and February 2023. Patients with primary or less than moderate mitral regurgitation were excluded. Mitral annular dimensions (area, perimeter, anteroposterior, intercommissural, and trigone-to-trigone diameter), mitral valve tenting geometry (tenting area and tenting height), and papillary muscle displacement were systematically measured at CT. Mitral regurgitation improvement was assessed at 1 month after TAVR by echocardiography. Logistic regression was performed to explore the association of mitral valve geometry with mitral regurgitation improvement after TAVR.
Results
A total of 75 patients (mean age, 74 ± 7 years; 32.0% female) with moderate to severe secondary mitral regurgitation were included in the final analysis. Mitral regurgitation improved in 49 patients and remained unchanged in 26 patients. Mitral annular dimensions, including area, perimeter, anteroposterior, and intercommissural diameter, were associated with mitral regurgitation improvement. Mitral valve tenting area (MVTA) and tenting height were risk factors for sustained mitral regurgitation. In addition, QRS duration > 120ms and atrial fibrillation had an impact on the mitral regurgitation improvement. Mitral annular area (OR, 1.41; 95%CI: 1.05, 1.90; p = 0.02) and MVTA (OR, 7.24; 95%CI: 1.72, 30.44; p = 0.007) were independent predictors of persistent secondary mitral regurgitation after TAVR.
Conclusions
Mitral annular area and MVTA were independent predictors of persistent secondary mitral regurgitation after TAVR.
Increased ERCP-related adverse event from premature urgent ERCP following symptom onset in acute biliary pancreatitis with cholangitis
Authors: Lee See Young , Jang Sung Ill , Park Sang Ho , Do Min Young , Lee Dong Ki , Cho Jae Hee 
Published: August 2023

Abstract

Acute biliary pancreatitis (ABP) with cholangitis requires endoscopic retrograde cholangiopancreatography (ERCP) within 24 hours to resolve ductal obstruction. However, this recommendation is based on the timing of emergency room (ER) visits. We wanted to determine the optimal timing of ERCP for ABP based on the timing of symptom onset, not the timing of the ER visit. We retrospectively reviewed 162 patients with ABP with cholangitis who underwent urgent ERCP (within 24 hours of ER admission). Area under the receiver operating characteristic (ROC) curve (AUC) was analyzed to determine differences in complication rates according to time from symptom onset. A difference in ERCP-related adverse events (AEs) was identified, and Youden’s J statistic was used to determine a cutoff time from symptom onset (18 hours). We compared mortality and complications based on this cutoff. Based on time to symptom onset, significantly higher rates of aspiration pneumonia (odds ratio [OR]: 4.00, 95% confidence interval [CI]: 1.15–13.92, P = 0.021) and post-ERCP hypotension (OR: 11.9, 95% CI: 1.39–101.33, P = 0.005) were observed in the ≤ 18-hour group than in the > 18-hour group. The study found that patients who underwent ERCP within 18 hours of symptom onset is associated with an increased risk of ERCP-related AEs.