bluuebunny/crossref_metadata_2025_split huggingface dataset:
Territory establishment and microhabitat selection of Bachman's sparrows in a Mississippi pine forest
Authors: Todaro Holly M. , Evans Kristine O. , Rush Scott A. , McConnell Mark D. 
Published: May 2023

AbstractBachman's sparrows (Peucaea aestivalis) are an obligate southern open pine forest species linked to disturbance regimes (e.g., fire, windthrow) that reduce canopy cover and promote herbaceous groundcover needed for nesting, foraging, and concealment from predators. Early successional groundstory characteristics suitable for Bachman's sparrows are ephemeral in nature, raising questions about the perceived visual cues created by vegetation structural characteristics and how these characteristics influence multi‐scale habitat selection. We quantified habitat selection for 40 breeding and post‐breeding male Bachman's sparrows within 5 separately managed open pine management sub‐units at Sam D. Hamilton Noxubee National Wildlife Refuge in east‐central Mississippi, USA, from 2020–2021. We captured and color‐banded 20 individuals each year and used weekly resight locations and resource selection function models to assess factors influencing territory establishment (i.e., second‐order selection) within our study area, and microhabitat selection (i.e., third‐order selection) within territories. Bachman's sparrow territory establishment was positively influenced by evergreen cover and fire disturbance, and negatively influenced by tree canopy cover, and distance to unpaved roads. Within territories, sparrows selected areas with a greater basal area of pine (18 m2/ha), more available perching options (>9), and an abundance of native herbaceous groundcover (>36%). They also selected recently burned areas (1–3 yr) with low visual obstruction (<40 cm), and a low percent coverage of leaf litter (<33%). A better understanding of territory establishment and microhabitat selection of the Bachman's sparrow underscores the importance of frequent fire and is helpful in guiding conservation and management efforts for this declining species.
Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer
Authors: Zimmer David , Plitt Gilman , Prendes Brandon , Ku Jamie , Silver Natalie , Lamarre Eric , Yilmaz Emrullah , Geiger Jessica , Nasr Christian , El Hage Lea , Skugor Mario , Cambpell Shauna , Koyfman Shlomo , Miller Jacob , Woody Neil , Heiden Katherine , Joshi Nikhil , Elsheikh Tarik , Li Hong , Scharpf Joseph 
Published: May 2023

ObjectivesTall cell variant (TCV) papillary thyroid cancer (PTC) is a subtype of PTC associated with aggressive tumor behavior, advanced stage, and higher rates of recurrence and mortality. The present study aimed to test an established dynamic risk stratification tool in the TCV population, with the goal of better predicting the postoperative course of these patients.Study DesignRetrospective chart review.MethodsA total of 94 patients with TCV who underwent total thyroidectomy with radioactive iodine ablation were retrospectively reviewed from 1998 through 2020. Biochemical, structural, and overall response to treatment was determined for each patient, based on postoperative thyroglobulin levels and imaging findings. Primary outcomes were locoregional and distant recurrence, presence of disease at final follow‐up, need for additional intervention, and disease‐specific mortality.ResultsPatients with TCV who were stratified as having an excellent overall response to treatment had lower rates of locoregional recurrence than indeterminate, biochemical incomplete, and structural incomplete responses (2.0%, 33.3%, 55.0%, and 85.7% at 5 years respectively, p < 0.001). The same was true for distant recurrence as well (2.0%, 9.0%, 35.1%, and 42.9%, p < 0.001). An excellent response was also associated with lower rates of presence of disease at final follow‐up, need for additional intervention, and disease‐specific mortality.ConclusionsAlthough TCV is an aggressive subtype associated with worse clinical outcomes than classical PTC, patients with an excellent overall response to treatment have significantly improved outcomes when compared to indeterminate, biochemical incomplete, and structural incomplete responses.Level of Evidence3 Laryngoscope, 133:2430–2438, 2023
Auto‐Substitutions to Optimize Perioperative Antimicrobial Prophylaxis: Pre‐Post Intervention Study
Authors: Tunio Suhaima , Dzioba Agnieszka , Dhami Rita , Elsayed Sameer , Strychowsky Julie E. 
Published: May 2023

BackgroundAppropriate administration of perioperative antibiotics can prevent antimicrobial resistance, adverse drug events, surgical site infections, and increased costs to the health care system for many surgeries in Otolaryngology—Head and Neck Surgery (OHNS).ObjectiveThe objective of the study is to achieve 90% compliance with evidence‐based perioperative antibiotic prophylaxis guidelines among elective surgical procedures in OHNS.MethodsThe pre‐intervention group consisted of patients undergoing elective surgical procedures in the 13 months prior to the interventions (September 2019–2020) whereas the post‐intervention group comprised patients undergoing elective procedures during the 8 months following the implementation (October 2020–May 2021). The 4 Es of knowledge translation and the Donabedian framework were used to frame the study. Components of the intervention included educational grand rounds and automatic substitutions in electronic health records. In June 2021, a survey of staff and residents assessed the self‐reported perception of following evidence‐based guidelines.ResultsCompliance with antimicrobial prophylaxis guidelines were evaluated based on agent and dose. The overall compliance improved from 38.8% pre‐intervention to 59.0% post‐intervention (p < 0.001). Agent compliance did not improve from pre‐ to post‐intervention, that is, 60.7% to 62.8%, respectively, (p = 0.68), whereas dose compliance improved from 39.6% to 89.2% (p < 0.001). Approximately 78.5% of survey respondents felt that they strongly agreed or agreed with always following evidence‐based antimicrobial prophylaxis guidelines.ConclusionCompliance with antimicrobial prophylaxis guidelines improved, primarily due to increased dosing compliance. Future interventions will target agent compliance and selected procedures with lower compliance rates.Level of Evidence3 Laryngoscope, 133:3403–3408, 2023
High‐Speed Mid‐Infrared Single‐Photon Upconversion Spectrometer
Authors: Zheng Tingting , Huang Kun , Sun Ben , Fang Jianan , Chu Yongyuan , Guo Hairun , Wu E , Yan Ming , Zeng Heping 
Published: May 2023

AbstractSensitive and fast mid‐infrared (MIR) spectroscopy is highly attractive in a variety of applications including astronomical observation, pharmaceutical synthesis, and environmental monitoring. However, the performance of conventional MIR spectrometers has long been hindered by the limited sensitivity of narrow‐bandgap detectors and/or the deficient brightness of broadband light sources. Here, an ultra‐sensitive and broadband MIR upconversion spectrometer, which integrates a supercontinuum source covering 1.5–4.2 m based on a silicon nitride nanophotonic waveguide, is devised and integrated. High‐efficiency and low‐noise nonlinear frequency upconversion is realized based on coincidence pulsed pumping with spectro‐temporal optimization, which enables leverage of silicon detectors for facilitating MIR single‐photon spectroscopy at 0.2 photons/nm/pulse. Furthermore, the upconversion‐based array spectrometer is manifested with high‐speed spectral acquisition rates beyond 200 kHz, which is about tenfold faster than the state‐of‐the‐art scan rates for FTIR‐based spectrometers at a comparable spectral resolution. The achieved features of broadband spectral coverage, single‐photon sensitivity, and sub‐MHz refreshing rate might open up new possibilities for infrared transient spectral measurements in combustion analysis, high‐throughput sorting, and reaction tracking, among others.
Activity of a TIE2 inhibitor (rebastinib) in a patient with a life‐threatening cervicofacial venous malformation
Authors: Triana Paloma , Lopez‐Gutierrez Juan Carlos 
Published: May 2023

AbstractTargeted therapy has become the first therapeutic option in many patients with vascular anomalies. A male 28‐year‐old patient presented a severe cervicofacial venous malformation involving half‐lower face, anterior neck, and oral cavity with progression despite multiple previous treatments, with a somatic variant in TEK (endothelial‐specific protein receptor tyrosine kinase) (c.2740C>T; p.Leu914Phe). The patient had facial deformity, daily episodes of pain and inflammation needing massive amount of medication, and difficulty in speech and swallowing, so rebastinib (a TIE2 kinase inhibitor) was approved for compassionate use. After 6 months of treatment, venous malformation had decreased in size and lightened, as well as improved quality‐of‐life scores.
A phase 1 study of simvastatin in combination with topotecan and cyclophosphamide in pediatric patients with relapsed and/or refractory solid and CNS tumors
Authors: Cash Thomas , Jonus Hunter C. , Tsvetkova Maya , Beumer Jan H. , Sadanand Arhanti , Lee Jasmine Y. , Henry Curtis J. , Aguilera Dolly , Harvey R. Donald , Goldsmith Kelly C. 
Published: May 2023

AbstractBackground3‐Hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors (statins) can inhibit tumor proliferation, angiogenesis, and restore apoptosis in preclinical pediatric solid tumor models. We conducted a phase 1 trial to determine the maximum tolerated dose (MTD) of simvastatin with topotecan and cyclophosphamide in children with relapsed/refractory solid and central nervous system (CNS) tumors.MethodsSimvastatin was administered orally twice daily on days 1–21, with topotecan and cyclophosphamide intravenously on days 1–5 of a 21‐day cycle. Four simvastatin dose levels (DLs) were planned, 140 (DL1), 180 (DL2), 225 (DL3), 290 (DL4) mg/m2/dose, with a de‐escalation DL of 100 mg/m2/dose (DL0) if needed. Pharmacokinetic and pharmacodynamic analyses were performed during cycle 1.ResultsThe median age of 14 eligible patients was 11.5 years (range: 1–23). The most common diagnoses were neuroblastoma (N = 4) and Ewing sarcoma (N = 3). Eleven dose‐limiting toxicity (DLT)‐evaluable patients received a median of four cycles (range: 1–6). There were three cycle 1 DLTs: one each grade 3 diarrhea and grade 4 creatine phosphokinase (CPK) elevations at DL1, and one grade 4 CPK elevation at DL0. All patients experienced at least one grade 3/4 hematologic toxicity. Best overall response was partial response in one patient with Ewing sarcoma (DL0) and stable disease for four or more cycles in four patients. Simvastatin exposure increased with higher doses and may have correlated with toxicity. Plasma interleukin 6 (IL‐6) concentrations (N = 6) showed sustained IL‐6 reductions with decrease to normal values by day 21 in all patients, indicating potential on‐target effects.ConclusionsThe MTD of simvastatin with topotecan and cyclophosphamide was determined to be 100 mg/m2/dose.
Fetal hydrops caused by a novel pathogenic MECOM variant
Authors: Wall Elizabeth , Forsyth Joan , Kinning Esther , Marton Tamás 
Published: May 2023

AbstractWe report a fetus with hydrops, congenital heart disease and bilateral radioulnar synostosis caused by a novel pathogenic MECOM variant. The female fetus was referred for post‐mortem examination after fetal hydrops and intrauterine death was diagnosed at 20 weeks gestation. Post‐mortem examination confirmed fetal hydrops, pallor, truncus arteriosus and bilateral radioulnar synostosis. Trio whole genome sequencing analysis detected a novel de novo heterozygous pathogenic loss‐of‐function variant in MECOM (NM_004991), associated with a diagnosis of Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2 (RUSAT‐2). RUSAT‐2 is a variable condition associated postnatally with bone marrow failure, radioulnar synostosis and congenital anomalies. RUSAT‐2 is not currently associated with a prenatal phenotype or fetal demise, and was not present on diagnostic NHS prenatal gene panels at time of diagnosis. This case highlights the diagnostic value of detailed phenotyping with post‐mortem examination, and of using a broad sequencing approach.
Early and severe tricuspid valve dysplasia in a fetus with cardiospondylocarpofacial syndrome due to a variant c.616T>G p.(Tyr206Asp) in MAP3K7
Authors: Vasishta Subrahmanya , Teli Akkatai S. , Vasudeva Akhila , Girisha Katta M. , Nayak Shalini S. 
Published: May 2023

AbstractCardiospondylocarpofacial syndrome (CSCF; MIM#157800) is a rare condition caused by monoallelic variants in the MAP3K7 gene. The characteristic features of CSCF include growth retardation, facial dysmorphism, carpal‐tarsal fusion, dorsal spine synostosis, deafness, inner ear malformation, cardiac septal defect and valve dysplasia. We present here a 20‐week‐old fetus with cardiospondylocarpofacial syndrome arising from a de novo variant c.616T>G p.(Tyr206Asp) in the MAP3K7 (NM_145331.3) gene with early and severe tricuspid valve dysplasia as a prenatal manifestation. Fetal echocardiography revealed tricuspid regurgitation with valve prolapse. Fetus had facial dysmorphism and dilated right atrium and right ventricle with tricuspid valve dysplasia on perinatal evaluation. To the best of our knowledge, this is the first report mentioning the prenatal manifestation of cardiospondylocarpofacial syndrome.
Noisy Random Quantum Circuit Sampling and its Classical Simulation
Authors: Zhang Meng , Wang Chao , Han Yongjian 
Published: May 2023

AbstractDemonstrating quantum advantage on noisy quantum devices is one of the most important tasks of quantum computing research in the near future. Random quantum circuit sampling is proposed as the most promising approach to the task and has been implemented in experiments for achieving quantum advantage. A series of encouraging computational complexity results, based on some plausible assumptions, show that this task is impossible to complete efficiently by classical computers. However, in practical experiments on noisy quantum devices, the approximate average‐case hardness and the effects of the noise need to be further checked. The competition between the classical simulation algorithm (mainly based on tensor network algorithms) and noisy quantum devices is the explicit way to understand quantum advantage in practice. This review briefly overviews the computational complexity arguments for the hardness of classical simulation of random quantum circuits sampling, then focus on various methods of classical simulation of quantum circuits based on tensor network method.
Event‐triggered cooperative control for uncertain multi‐agent systems and applications
Authors: Wang Shihao , Zheng Shiqi , Ahn Choon Ki , Shi Peng , Jiang Xiaowei 
Published: May 2023

AbstractThis paper investigates the event‐triggered cooperative output regulation problem for uncertain multi‐agent systems, demonstrating that the output regulation error of the uncertain multi‐agent system can converge to a small neighborhood of the origin. The proposed method has several notable features. Firstly, both the leader and follower systems contain unknown parameters, and follower systems can be heterogeneous. Secondly, the controller only requires the relative output of each agent, rather than the absolute output or state. Thirdly, the controller is fully distributed, which implies that it does not rely on any global information. In order to achieve the above purpose, a fully distributed reduced‐order observer is proposed with new adaptive laws. Furthermore, new adaptive event‐triggered mechanisms are designed on the basis of the neighborhood regulation error (NRE) and the observational regulation error (ORE). Finally, the proposed approach is validated through simulation and experiment on a multi‐joint robot manipulator.
Data‐driven control for networked systems with multiple packet dropouts
Authors: Chen Wenli , Li Xiaojian 
Published: May 2023

AbstractThis paper investigates data‐driven control for a class of networked control systems with multiple packet dropouts and unknown system parameters. Here, multiple packet dropouts occur randomly in the controller‐to‐actuator (C/A) and sensor‐to‐controller (S/C) channels, where successive packet dropouts are limited by known upper bounds. By introducing the summation inequality, a model‐based mean‐square asymptotic stability condition is established for the closed‐loop networked control system with the potential to migrate to a data‐driven solution. Then, the data‐driven mean‐square asymptotic stability condition for the closed‐loop system is presented by merging the model‐based stability condition with noisy data‐parameterized representations. On this basis, the data‐driven controller gain design approaches for combining unknown and known input gain matrices are presented in turn. Finally, two simulation examples are provided to show the applicability of the developed approaches.
Investigation of Biological Activities of Tetra‐substituted Phthalocyanines Bearing Tetraethyleneglycol Monomethyl Ether Chains at Peripheral and Non‐peripheral Positions
Authors: Samsunlu Taylan , Akkoç Berkay , Özçeşmeci Mukaddes , Akın Mustafa , Şaki Neslihan , Hamuryudan Esin 
Published: May 2023

AbstractThis study describes the synthesis and characterization of peripherally and non‐peripherally substituted copper(II) and cobalt(II) phthalocyanines bearing tetraethyleneglycol monomethyl ether chains. In addition, the metal‐free and zinc(II) phthalocyanine derivatives were prepared according to the referred procedure. All newly synthesized phthalocyanines were characterized using some spectroscopic techniques such as elemental analysis and fourier transform infrared, ultraviolet‐visible, and mass spectroscopies. The effects of solvent type and concentration on aggregation properties of phthalocyanines were studied, as well. The biological activities of a series of these peripherally and non‐peripherally tetra‐substituted phthalocyanines were investigated. The effects of the central metal ion and the position of the substituent on biological activities of phthalocyanines were also compared. When the antioxidant activities of the synthesized molecules were evaluated by the 2,2‐diphenyl‐1‐picrylhydrazyl method, 1,8/11,15/18,22/25‐tetrakis[2‐(2‐(2‐(2‐methoxyethoxy)ethoxy)ethoxy)ethoxy]phthalocyaninatocobalt(II) (63.17±0.012 %) showed the highest activity. The highest reducing power activity was obtained with the 2,9/10,16/17,23/24‐tetrakis[2‐(2‐(2‐(2‐methoxyethoxy)ethoxy)ethoxy)ethoxy]phthalocyaninatozinc(II) molecule. In the antibacterial activity studies using the disc diffusion method, 2,9/10,16/17,23/24‐tetrakis[2‐(2‐(2‐(2‐methoxyethoxy) ethoxy)ethoxy)ethoxy]phthalocyaninatocopper(II) exhibited the highest inhibition activity on both gram negative (18±0.23 mm) and gram positive (23±0.07 mm) strains. On the other hand, 2,9/10,16/17,23/24‐tetrakis[2‐(2‐(2‐(2‐methoxyethoxy)ethoxy) ethoxy)ethoxy]phthalocyaninatozinc(II) and 1,8/11,15/18,22/25‐tetrakis[2‐(2‐(2‐(2‐methoxyethoxy)ethoxy)ethoxy)ethoxy]phthalo‐cyaninatozinc(II) compounds presented hemolytic activity against sheep blood in the hemolytic activity studies. The results confirmed that the synthesized molecules demonstrated average antioxidant activity compared to standard antioxidants. 2,9/10,16/17,23/24‐Tetrakis[2‐(2‐(2‐(2‐methoxyethoxy)ethoxy)ethoxy)ethoxy]phthalo‐cyaninatocopper(II), 2,9/10,16/17,23/24‐tetrakis[2‐(2‐(2‐(2‐methoxy ethoxy)ethoxy)ethoxy)ethoxy]phthalocyaninatozinc(II) and 1,8/11, 15/18,22/25‐tetrakis[2‐(2‐(2‐(2‐methoxyethoxy)ethoxy)ethoxy) ethoxy]phthalocyaninatozinc(II) complexes could remarkably inhibit S. aureus and CuPc‐1 complex E. coli growth.
Samarium(III) Triflate in Organic Synthesis: a Mild and Efficient Catalyst
Authors: Dey Asish Kumar , Majhi Sasadhar 
Published: May 2023

AbstractLanthanides have shown great potential in the field of magnetic materials, telecommunications, hard‐disk drives, catalysis, medicine, agriculture, and more. Recently, lanthanide complexes have gained significant attention in cancer diagnosis and therapy because of the multifunctional chemical and magnetic activities of the lanthanide‐ion 4 f electronic configuration. Among lanthanides, samarium metal and its derivatives have been the subject of many applications in organic transformations. Various metal triflates such as Bi(OTf)3, Yb(OTf)3, In(OTf)3, Sc(OTf)3, Er(OTf)3, Ce(OTf)3, Sm(OTf)3, and others play a profound role in developing novel eco‐friendly protocols in organic synthesis with excellent efficiency and selectivity. Among lanthanide triflate, samarium(III) triflate has a remarkable contribution in synthesizing promising organic molecules as it has been shown to be moisture tolerant and a reusable Lewis catalyst under mild conditions. The present review aims to focus on different useful protocols using samarium(III) triflate as an efficient catalyst for the first time elegantly.
Design, Synthesis, Characterization and Biological Activities of Novel S‐(Acyloxy)butyl‐N,N‐Diethyldithiocarbamate Compounds
Authors: Karimov Aliverdi , Taslimi Parham , Orujova Arzu , Mammadova Khuraman , Kısa Dursun , Farzaliyev Vagif , Sujayev Afsun , Sadeghian Nastaran , Taskin‐Tok Tugba , Alwasel Saleh , Gulcin Ilhami 
Published: May 2023

AbstractIn this study, S‐(Acyloxy)butyl‐N,N‐Diethyldithiocarbamate compounds (P1‐P7) were synthesized by s‐alkylation of N,N‐diethyldithiocarbamate sodium trihydrate with 4‐chlorobutylcarboxylates. P1–P7 were characterized by full infrared, NMR spectroscopy and elemental analyses. Additionally, the impacts of these compounds were investigated on some metabolic enzymes and then compared to the reference compounds. It was observed that the DEDTCA esters generally had lower IC50 and Ki values. Among them, P4 and P6 molecules had lower IC50 with 112.47 and 111.55 μM; and Ki values: 105.53±7.17 and 102.06±5.08 μM against AChE, respectively. Furthermore, molecular docking simulations approved the binding interaction patterns and structural orientations of N,N‐diethyldithiocarbamic acid derivatives within the binding sites of AChE, BChE and α‐glucosidase. Taken together, the compound P6 performs strong distant bond interactions against tacrine for AChE and BChE enzymes within the scope of in silico study. The compound P4, on the other hand, exhibits good interactions with the target by making hydrophobic, pi‐sulfur and pi‐sigma bonds as well as hydrogen bonds compared to acarbose as standard compound against α‐glucosidase. These can be further analyzed as potent candidate compounds in biological studies of the respective enzymes.