bluuebunny/crossref_metadata_2025_split huggingface dataset:
Szövegértés alapú narratívaalkotás középiskolás korban
Authors: Laczkó Mária 
Published: September 2023

A szövegértés-alapú narratívaalkotás összetett folyamata során a hallott tartalom visszaadása történik saját szavainkkal. Ez olyan félreproduktív beszédhelyzet, amelyben a létrehozott narratíva a spontán beszéd vizsgálatával egyidejűleg a szövegértés elemzését is lehetővé teszi. Ez a feladattípus a közoktatásban az alsó tagozaton is szokásos iskolai gyakorlat. Vizsgálata később, így a középiskolában is fontos lehet, hiszen a produkciós jellemzőkből lehet a percepciós sajátosságokra következtetni, valamint számtalan iskolai feladat, így például a jegyzetelés alapját képezheti, előfordul az idegen nyelvű érettségi vizsga részfeladataként és egyes nyelvvizsgák részeként is. Jelen munka 11. osztályos technikumi és szakközépiskolai tanulók szövegértés-alapú narratívaalkotási folyamatát elemzi a létrehozott produktumok hossza, szógazdagsága alapján. Az elemzés kiterjed továbbá a helyesen felidézett tartalmi elemek mennyiségére, minőségére és a tartalmi elemek felidézésekor megjelenő hibák tipizálására. A tanulmány eredményei rámutatnak a feladattípus középiskolai gyakoroltatásának a szükségességére.
Assessing the accuracy of the Revised Cardiac Risk Index compared to the American Society of Anaesthesiologists physical status classification in predicting Pulmonary and Cardiac complications among non-cardiothoracic surgery patients at Muhimbili National Hospital
Authors: Khamisi Ramadhan H. , Chrisant Elias Makoye , Muhamba Frank , Mwanga Ally Hamis , Mbuyamba Hervé Tshikomba 
Published: September 2023

Abstract

Background The Revised Cardiac Risk Index (RCRI) and the American Society of Anaesthesiologists (ASA-PS) classification system are two commonly used tools for preoperative risk assessment. This study aimed to assess the accuracy of RCRI compared to the ASA-PS classification system in preoperative risk assessment for pulmonary and cardiac problems among non-cardiothoracic surgery patients admitted at Muhimbili National Hospital (MNH).Methods This was a prospective cross-sectional study design conducted from August 2022 to April 2023 among 184 patients of 18 years and above admitted at MNH for elective non-cardiothoracic surgery. Data Analysis was conducted using STATA software version 16. Means and standard deviations were used to summarize continuous data. Frequencies and percentages were used to summarize categorical data. The logistic regression and ROC curve analysis were used to determine the correlation between variables.Results The majority of patients (43.3%) had an RCRI score of 1 point, and 39.9% were classified as ASA class 1. Patients in ASA classes 3 and 4 had higher odds of developing cardiac and pulmonary complications (AUC = 0.75 and 0.77, respectively). Patients with an RCRI score of 2 or ≥ 3 points were also more likely to experience cardiac and pulmonary complications (AUC = 0.73 and 0.72, respectively). There was no significant difference in the predictive ability of the two tools. Both RCRI and ASA-PS classification systems were equally effective in predicting these complications.Conclusion Both the RCRI and the ASA-PS classification system demonstrated good predictive ability for cardiac and pulmonary complications among patients undergoing non-cardiothoracic surgery.
Improved Therapeutic Efficacy of Doxorubicin Chemotherapy with Cannabidiol in 4T1 Mice Breast Cancer Model
Authors: Tabatabaei Koorosh , Moazzezi Sara , Emamgholizadeh Mohammadreza , Vaez Haleh , Baradaran Behzad , Shokouhi Behrooz 
Published: September 2023

Abstract
Background
Breast cancer is one of the world’s most frequently diagnosed malignancy and the second highest cause of all cancers in females. This cancer mortality is mostly due to lung metastasis. High dose chemotherapy is one of therapeutic strategies beside others. Doxorubicin (DOX) is a widely used chemotherapy agent. however, use of DOX is limited due to its dose- depended cardiotoxic effects. Recently, cannabidiol (CBD) shows anti-tumoral and cardioprotective effects so we aimed to CBD administration with high-dose DOX chemotherapy can improve anticancer effect and reduce cardiotoxicity side effect.
Method
Mice breast cancer model established by injecting 4T1 cell lines. One group did not injected by 4T1 cells as a not cancerous group and administrated normal saline (1ml). In cancerous groups one group consider as cancerous control and administrated normal saline (1ml), other one administrated only DOX (5 mg/kg, IV) on day 1,7,14, other administrated CBD (5 mg/kg, IP) as DOX schedule, nex group administrated CBD and DOX at same time with previews doses and schedule, the last one administrated CBD one day before DOX as pretreatment. On day 21 all mice sacrificed, heart and lungs obtained and histological section preformed. SOD2, iNOS, MMP2, MMP9 evaluated through western blot and TUNEL test preformed for breast tumor.
Results
TUNEL test demonstrated CBD + DOX and pretreatment group was significantly green even compare to DOX group (P < 0.05). In CBD + DOX SOD2 increased and iNOS, MM2 and MMP9 decreased.
Conclusions
This study shows CBD + DOX at same time can increase anti-tumoral effect and reduce DOX cardiotoxicity effect. However CBD alone had a cardioroxic effect.
Optimization process and influence of processing conditions on physical, thermal and textural characteristics of Nigerian pasta produced from acha flour and defatted moringa powder
Authors: OlayemiRaji Akeem , Olaitan Isiaka Mubarak , Omeiza Maxwell Yemmy Mitchel , Sanusi Mayowa Saheed 
Published: September 2023

Abstract
The consumption of Nigerian lesser known crops has been advocated by many researchers. Replacement of wheat flour with acha and de-fatted moringa cake in pasta production was investigated to reduce dependence on wheat flour. Optimization process of pasta production from acha flour (AF) and defatted moringa powder (DMP) carried out using standard method, with the objectives of determining optimum processing condition by applying hybrid of Taguchi Orthogonal Array Design and Response Surface Methodology of Design Expert version 6.0. The independent variables were barrel temperature (110–150 ºC), barrel speed (240–360 rpm) and moisture content (30–40%). The responses ranged as follows: hardness (18.96–27.83 N), springiness (0.41–0.71), adhesiveness (0.09–0.59 N/m2), cohesiveness (0.35–0.64), chewiness (3.85–11.89 N/m2), gumminess (9.23–17.63 N/m2), energy peak (0.01–0.02 kg/m2), color characteristics (L* (0.07–2.20), a* (0.32–1.07) and b* (0.21–2.11)), cooking time (4.00–6.00 min), cooking loss (5.66–8.05 g/100g), water uptake (10.08–98.65%), elongation ratio (0.82–1.08), specific heat capacity (Cp) (177.31–196.45 kJ/kg/K), thermal conductivity (27.31–29.64 W/m/K) and thermal diffusivity (8.17–8.81 x 10− 6 m2/s). The variation in processing conditions significantly (p < 0.05) influenced all the responses. However, the principal component analysis (PCA) of the physical, thermal and instrumental textural characteristics of pastas showed positive correlations except for adhesiveness and overall acceptability. Conclusively, dough moisture content of 39.85%, barrel speed of 240 rpm and barrel temperature of 110°C gave the optimal extrusion process condition for the production of high-quality pasta.
Cavity-mediated long-range interactions in levitated optomechanics
Authors: Novotny Lukas , Vijayan Jayadev , Piotrowski Johannes , Gonzalez-Ballestero Carlos , Weber Kevin , Romero-Isart Oriol 
Published: September 2023

Abstract
The ability to engineer cavity-mediated interactions has emerged as a powerful tool for the generation of non-local correlations and the investigation of non-equilibrium phenomena in many-body systems. Levitated optomechanical systems have recently entered the multi-particle regime, with promise for using arrays of massive strongly coupled oscillators for exploring complex interacting systems and sensing. Here, by combining advances in multi-particle optical levitation and cavity-based quantum control, we demonstrate, for the first time, programmable cavity-mediated interactions between nanoparticles in vacuum. The interaction is mediated by photons scattered by spatially separated particles in a cavity, resulting in strong coupling (Gzz/Ωz = 0.238 ± 0.005) that does not decay with distance within the cavity mode volume. We investigate the scaling of the interaction strength with cavity detuning and inter-particle separation, and demonstrate the tunability of interactions between different mechanical modes. Our work paves the way towards exploring many-body effects in nanoparticle arrays with programmable cavity-mediated interactions, generating entanglement of motion, and using interacting particle arrays for optomechanical sensing
Belief in omens and superstitions among patients with chronic neurological disorders
Authors: Mameniškienė Rūta , Kizlaitienė Rasa , Lokominienė Rūta Kaladytė , Puteikis Kristijonas 
Published: September 2023

Abstract
Chronic neurological disorders may affect various cognitive processes, including religiosity or superstitious belief. We tested the hypotheses that superstitious beliefs are less prevalent in Parkinson’s disease (PD) and more prevalent in people with epilepsy (PWE) than in patients with multiple sclerosis (MS) or healthy controls (HCs). We conducted an anonymous survey among outpatients and HCs by asking them to ascribe meaning or report belief for 27 culturally adapted statements (9 omens and 18 superstitions). The sum of items that a respondent believes in was labelled the superstition index (SI). The SI was compared between groups by means of the Kruskal-Wallis (H) test and negative binomial regression modelling. Two-step cluster analysis was performed to discern different subgroups based on answers to the items of the SI. There were 553 respondents who completed the questionnaire (183 PWE, 124 patients with PD, 133 with MS and 113 HCs). Complete SI scores were collected for 479 (86.6%) participants and they were lower in patients with PD (n = 96, Md = 1, IQR = 0-5.75) in comparison to those with epilepsy (n = 155, Md = 6, IQR = 1–14), MS (n = 120, Md = 4, IQR = 0–12) or HCs (n = 108, Md = 4.5, IQR = 1–10), H(3) = 26.780, p < 0.001. The negative binomial regression model (n = 394, likelihood ratio χ2 = 35.178, p < 0.001), was adjusted for sex, place of residence, income and education, and female sex was the only characteristic associated with the SI (β = 0.423, OR = 1.526, 95% CI = 1.148 to 2.028). Both female sex (β = 0.422, OR = 1.525, 95% CI = 1.148 to 2.026) and Parkinson’s disease (β=-0.428, OR = 0.652, 95% CI = 0.432 to 0.984) were significant predictors of the SI when age was removed from the model. Two-step cluster analysis resulted in individuals with PD being grouped into “extreme non-believer”, “non-believer” and “believer” rather than “non-believer” and “believer” clusters characteristic for PWE, patients with MS and HCs. Our study suggests that individuals with PD believe in less superstitions than patients with MS, PWE or HCs. The results of this investigation should be independently confirmed after adjusting for PD-specific variables.
Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses
Authors: Herold Marco , Marca John La , Aubrey Brandon , Yang Bruce , Chang Catherine , Wang Zilu , Kueh Andrew , Tai Lin , Wilcox Stephen , Milla Liz , Heinzel Susanne , Vremec David , Whelan Lauren , koenig christina , Kaloni Deeksha , Voss Anne , Strasser Andreas , Diepstraten Sarah , Kelly Gemma 
Published: September 2023

Abstract
Whole-genome screens using CRISPR technologies are powerful tools to identify novel tumour suppressors as well as factors that impact responses of malignant cells to anti-cancer agents. Applying this methodology to lymphoma cells, we conducted a genome-wide screen to identify novel inhibitors of tumour expansion that are induced by the tumour suppressor TRP53. We discovered that the absence of Arrestin domain containing 3 (ARRDC3) increases the survival and long-term competitiveness of MYC-driven lymphoma cells when treated with anti-cancer agents that activate TRP53. Deleting Arrdc3 in mice caused perinatal lethality due to various developmental abnormalities, including cardiac defects. Notably, the absence of ARRDC3 markedly accelerated MYC-driven lymphoma development. Thus, ARRDC3 is a new mediator of TRP53-mediated suppression of tumour expansion, and this discovery may open new avenues to harness this process for cancer therapy.
Can network infrastructure development help farmers cross the "digital divide"?
Authors: Meng Xiangtai , Sun Shiying , Ding Xin 
Published: September 2023

Abstract
Addressing the digital divide that plagues rural areas has become an important issue in narrowing the urban-rural gap and achieving common prosperity. This article examines the impact of network infrastructure on rural households' ability to cross the digital divide by using the "broadband rural" strategy as a proxy variable for network infrastructure and combining data from the China Family Panel Studies (CFPS) with a score propensity matched difference-in-differences model (PSM-DID). The results show that network infrastructure can help farmers cross the access and use divide, but does not contribute significantly to crossing the ability divide in the current period. A triple difference model (DDD) was introduced to test the effect of network technology training on the contribution of network infrastructure to the ability gap, and the ability gap needs to be based on the use gap, so there is a delay in the response of the ability gap to policy. Further analysis reveals that network infrastructure mainly facilitates non-farm occupational groups to cross the capability divide, and facilitates middle-aged and young people to cross the digital divide, and does not have significant effects on groups involved in agricultural work and older people. In view of this, the network infrastructure should be continuously promoted, public service training on digital skills should be organized, electronic products and information services should be created exclusively for the elderly group and the group involved in agricultural production, and the ability of farmers to apply the network to their production life should be strengthened.
Conjugated linoleic acid reduces lipid accumulationvia down-regulation expression of lipogenic genes and up-regulation of apoptotic genes in grass carp（Ctenopharyngodon idella）adipocyte in vitro
Authors: Yu Hua , Zou Zhao-xia , Wei Wei , Li Ying 
Published: September 2023

Abstract
The relationship between conjugated linoleic acid (CLA) and lipogenesis has been extensively studied in mammals and some cell lines, but it is relatively rare in fish, and the potential mechanism of action of CLA reducing fat mass remains unclear. The established primary culture model for studying lipogenesis in grass carp (Ctenopharyngodon idella) preadipocytes was used in the present study, and the objective was to explore the effects of CLA on intracellular lipid and TG content, fatty acid composition, and mRNA levels of adipogenesis transcription factors, lipase and apoptosis genes in grass carp adipocytes in vitro. The results showed that CLA reduced the size of adipocyte and lipid droplet, decreased the content of intracellular lipid and TG, which was accompanied by a significant downregulation of mRNA abundance in the transcriptional regulators (PPARγ, C/EBPα, SREBP-1c ), lipase genes(LPL、 FAS、ACC) and decreasing the content of SFAs, n-6 PUFA, increasing the content of MUFA and n-3 PUFA in primary grass carp adipocyte. In addition, CLA induced adipocyte apoptosis through downregulated anti-apoptotic gene(Bcl-2 ) mRNA level, upregulated pro-apoptotic genes(TNF-α, Bax, Caspase-3, and Caspase-9) mRNA level in a dose-dependent manner. These findings suggest that CLA can act on grass carp adipocytes through various pathways, including decreasing adipocyte size, altering fatty acid composition, restraining adipocyte differentiation, promoting adipocyte apoptosis, and thereby reducing lipid accumulation.
Is embodied renewable energy transfer greening the global supply chain?
Authors: Yang Yu , Chen Yan , Poon Jessie , Qian Xiaoyin , Zhou Yannan , Xia Siyou 
Published: September 2023

Abstract
Energy underpins international trade, and a greener energy mix can contribute to cleaner global supply chains (GSCs). This paper examines how energy transition has influenced GSC greening through embodied renewable energy transfer. Specifically, we analyze the contribution of countries/regions and sectors to the greening process from 2011 to 2021. We find some evidence of GSC greening over the period as the ratio of renewable energy in total transferred energy increased from 4.2% to 7.6%. Emerging economies that have advanced rapidly in energy transition are gradually overtaking developed countries in their contribution to GSC greening. Sectors with a higher electrification rate are main contributors to GSC greening led by significant inter-sectoral spillovers from the heavy industry and business services. However, transfer of embodied renewable energy by high-income developed countries is concentrated in other high-income countries raising concerns of limited access by low-income developing countries and the amelioration of global energy welfare inequality.
Targeting ErbB and tankyrase1/2 prevent the emergence of drug tolerant persister cells in ALK fusion positive lung cancer
Authors: Yoshiura Shigeki , Fujimura Takaaki , Furugaki Koh , Mizuta Hayato , Nishio Makoto , Uchibori Ken , Miyauchi Eisaku , Hayashi Hidetoshi , Katayama Ryohei 
Published: September 2023

Abstract

Targeting the drug tolerant persister (DTP) state in cancer cells should prevent further development of resistance mechanisms. This study explored combination therapies to inhibit alectinib-induced DTP cell formation from anaplastic lymphoma kinase–positive non-small cell lung cancer (ALK+ NSCLC) patient–derived cells. After drug-screening 3114 compounds, pan-HER inhibitors (ErbB pathway) and tankyrase1/2 inhibitors (Wnt/β-catenin signaling) emerged as top candidates to inhibit alectinib-induced DTP cells growth. We confirmed knockdown of both TNKS1/2 in DTP cells recovered the sensitivity to alectinib. Further, our study suggested knockdown of TNKS1/2 increased stability of Axin1/2, which induced β catenin degradation and decreased its nuclear translocation, thereby suppressing transcription of antiapoptotic and proliferation-related genes (survivin, c-MYC). Targeting both pathways with alectinib+pan-HER inhibitor and alectinib+TNKS1/2 inhibitor suppressed alectinib-induced DTP cells, and the triple combination almost completely prevented the appearance of DTP cells. In conclusion, combination with ALK-TKI, pan-HER and TNKS1/2 inhibitors prevents the emergence of DTP in ALK+ NSCLC.
Magnetic Activity Cycle Detection Based on Multiple Random Spectral Observations
Authors: Shen Yu-Fu 
Published: September 2023

Abstract
The solar magnetic activity cycle has a profound impact on our lives, yet its underlying causes remain elusive. While similar cycles have been observed in other stars, these results are scarce due to the significant challenge posed by the length of time required for observation. Continuous observation over an extended period is a luxury, making it difficult to gather large samples. However, multiple random observations can be made at a lower cost, and flexible time management enables non-professionals to become competent. In this study, new magnetic activity cycle candidates are identified by utilizing multiple random observations of S-indices of several stars that were accidentally discovered by the Large Sky Area Multi-Object Fiber Spectroscopic Telescope. The S-index observation is less challenging, suggesting that specialized commercial small equipment may be designed, then sold, or distributed to the public.
Simulation experimental investigations into material removal mechanism of SiC ceramic by using drilling-grinding composite machining
Authors: Liu Yin , Chen Jiahao , Sun Xingwei , Dong Zhixu , Yang Heran , Zhao Hongxun , Mu Shibo , Zhang Weifeng , Gong Yadong , Liu Weijun 
Published: September 2023

Abstract
To investigate the machining mechanism of silicon carbide (SiC) ceramic materials, this study utilized sintered diamond tools to perform drilling and grinding simulations on the material, and developed a drilling model for SiC ceramic materials. By analyzing parameters such as surface morphology, stress, and cutting force, the material removal mechanism of SiC ceramic materials was revealed, and the effects of drilling parameters on cutting force, torque, and residual stress were studied. Experimental results indicate that during the abrasive cutting process, the hard contact behavior of irregular abrasive grains significantly affects material removal, leading to failure forms such as chip collapse, hole and groove cracking, and crack propagation. With an increase in the feed rate of the abrasive grains, the drilling force shows a certain range of growth patterns. The axial force is positively correlated with spindle speed and feed rate, with the feed rate having a more significant impact on the magnitude of the axial force. Additionally, as the feed rate increases, the torque also increases. The radial residual stress mainly manifests as residual tensile stress.
Morphology and SSR markers reveal the genetic diversity of Elymus species germplasm in northwestern China
Authors: Zhang Qiang , Li Shucheng , Guo Shuhong , Tian Hongling 
Published: September 2023

Abstract

The relationship between the genetic diversity and genetic characteristics of wild plant germplasm can provide insights for better utilization and conservation of genetic resources. Bunchgrass species in the genus Elymus are important for forage and grassland restoration in Northwest China. In this study, eight phenotypic traits were evaluated in 81 accessions of four Elymus species in the northwest region of China, and genetic diversity analysis was performed using 16 simple sequence repeat (SSR) markers. In the phenotypic trait analysis, Elymus sibiricus had the highest coefficient of variation for single-plant weight(58.24%) and the lowest coefficient of variation for the number of spikelets(0.005%). Clustering based on phenotypic traits placed all varieties into four groups, which were also supported by principal component analysis (PCA). 16 pairs of SSR markers were screened with high polymorphism, with a polymorphism information content (PIC) range of 0.3648–0.7794 and an interspecific PIC range of 0.465–0.611 in Elymus species. The unweighted pair-group method with arithmetic mean approach applied to SSR marker data also divided the 81 accessions into four groups, similar to the results based on phenotypic traits. The results of PCA and population structure analysis based on SSR data were similar. The findings presented here will facilitate the collection and conservation of Elymus germplasm resources and provide theoretical references for the future classification, breeding, innovation, utilization, and conservation of germplasm.