bluuebunny/crossref_metadata_2025_split huggingface dataset:
Komitmen Pimpinan Pada Penurunan Stunting Di Kabupaten Tuban Jawa Timur
Authors: Shofiya Dian , Soesanti Inne , Rachmaniah  , Winarko  , Mujayanto  , Zahrotul Jannah Sa’idah 
Published: April 2023

Stunting menyebabkan lemahnya persaingan sumber daya manusia (SDM) suatu negara, karena selain tampilan fisik juga berdampak pada kemampuan kognitif. Hasil SSGI21 menyatakan prevalensi stunting di Indonesia sebesar 24,4%. Pemerintah menargetkan prevalensi stunting tahun 2024 menjadi 14%. Untuk mencapai angka tersebut memerlukan komitmen ditingkat pusat sampai dengan desa. Tujuan penelitian adalah untuk mengetahui komitmen pemerintah dan masyarakat desa dalam percepatan penurunan stunting. Metode penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologi. Focus Group Discusion merupakan cara pengumpulan data secara kualitatif. Partisipan dalam FGD adalah kepala desa dan pamong desa, bidan desa, bidan Puskesmas, serta anggota TPPS (Tim Percepatan Penurunan Stunting) di tingkat desa. Penelitian dilakukan di 10 desa lokus stunting di Kabupaten Tuban, Jawa Timur. Hasil penelitian menunjukkan bahwa komitmen pimpinan telah ada tetapi belum operasional. Komitmen pendanaan masih bersifat umum belum focus pada balita stunting dan keluarga beresiko stunting, sangat bergantung pada dana pemerintah pusat dan bersumber pada dana desa yang sangat terbatas berupa pemberian makanan tambahan di posyandu. Sumberdaya manusia telah banyak melakukan kegiatan tetapi belum semua terlibat dalam kegiatan percepatan penurunan stunting, misalnya bisang pendidikan dalam hal ini adalah PAUD. Saran yang dapat diberikan agar pimpinan desa melakukan sosialisasi kepada seluruh tim percepatan penurunan stunting, memfokuskan sekaligus menambah besarnya anggaran untuk balita stunting dan keluarga beresiko stunting dan melibatkan semua komponen masyarakat untuk melakukan percepatan penurunan stunting.

Kata kunci : stunting, komitmen pimpinan, dana desa.
KEARIFAN LOKAL DALAM PAWON URIP UNTUK PENCEGAHAN STUNTING DI KABUPATEN LUMAJANG JAWA TIMUR
Authors: Ghaffar Muhammad Luthfi Abdul , Riyanto Edi Dwi , Nadhiroh Siti Rahayu , Fatah Mohammad Zainal , Nurmala Ira 
Published: April 2023

Stunting dipahami sebagai rendahnya tinggi badan menurut umur pada anak. Indeks gizi tinggi-untuk-usia adalah umum untuk mengukur stunting masa kanak-kanak. Anak stunting tidak selalu kurus, bahkan ada yang kelebihan berat badan dibandingkan tinggi badannya.. Salah satu cara untuk mengatasi stunting adalah dengan memastikan kemanan pangan dan pemenuhan zat gizi secara berkelanjutan. Salah satu cara untuk mewujudkan hal tersebut adalah dengan penerapan Pawon Urip. Pawon Urip merupakan kearifan lokal Kabipaten Lumajang yang didasari oleh konsep kekeluargaan, gotong royong, empati dan juga solidaritas antar warga. Tujuan paper ini adalah menjelaskan bagaimana Pawon Urip di Kabupaten Lumajang Jawa Timur memanfaatkan dan mengembangkan nilai-nilai kearifan lokal yaitu gotong royong dan solidaritas terhadap masyarakat sekitar untuk mencegah stunting sebagai masalah bersama warga. Paper ini merupakan kajian kualitatif terhadap Pawon Urip. Data utama dikumpulkan dengan cara wawancara yang dilakukan dengan sejumlah pegiat Pawon Urip di Lumajang dan beberapa anggota masyarakat. Selain itu dikumpulkan juga data kegiatan Pawon Urip, data statistic stunting, dan data sekunder lainnya yang terkait. Data dianalisis secara tematik untuk menemukan aspek kearifan lokal dalam menghadapi masalah bersama berupa stunting. Hasil dari penelitian ini adalah penerapan Pawon Urip di Desa Kloposawit membantu masyarakat dalam memenuhi kebutuhan gizi selama pandemi dan dapat mendukung keberlanjutan konsumsi pangan dan peningkatan status gizi Diharapkan paper ini bisa menyajikan contoh praktek baik pencegahan stunting dengan memanfaatkan kearifan lokal.
Determinant of Adherence to iron supplementation in Adolescent Girl In Spesific Intervention For Stunting Prevention: Systematic Review
Authors: Feriyanti Alma , Deviatin Nafiatus Sintya , Nurmala Ira , Widati Sri , Atmaka Dominikus Raditya 
Published: April 2023

An increase in the prevalence of anemia in young women will affect the quality of life and their offspring. Adolescent girls who experience anemia are at risk for anemia during pregnancy. Anemia in pregnant women will impact giving birth to stunted babies. Iron supplementation is a specific intervention effort to prevent anemia in female adolescents. This study aims to analyze the determinants of adherence to iron supplementation in young women and specific interventions to prevent stunting. This study uses a systematic review using PRISMA. Five electronic databases are used: Scopus, ScienceDirect, Wos, SAGE, and Google Scholar. The articles used in this research are 10 articles. The inclusion criteria for this study were articles published within five years, namely, 2018-2022, full text, open access, and in Indonesian and English. The determinants of adherence to iron supplementation are influenced by several factors, including sociodemographic factors such as the mother's occupation, education, and adolescent age. Intrapersonal factors such as young women's motivation and perceived benefits. Interpersonal factors such as support from parents, peers, and teachers. Institutional factors such as school support in the distribution of iron tablets. The compliance of young women in consuming iron tablets is influenced by sociodemographic, intrapersonal, intrapersonal, and institutional factors. There is a need for health education for young women and parents as well as strengthening commitment to schools so that they receive support in the implementation of iron supplementation as a specific intervention for stunting prevention

Keywords: Compliance, Iron Tablets, Adolescents, Anemia, Stunting
TAPHONOMIC SIGNATURES IN DEAD SHELLS OF THE INVASIVE GASTROPOD RAPANA VENOSA (VALENCIENNES, 1846) AFTER TWO DECADES IN THE RÍO DE LA PLATA, URUGUAY
Authors: GÓMEZ-MADURO MARÍA CECILIA , ROJAS ALEJANDRA , MARTÍNEZ SERGIO 
Published: April 2023

ABSTRACT
Rapana venosa (Valenciennes, 1846) is an invasive gastropod, the arrival of which in the Río de La Plata estuary 22 years ago is well-documented. Rapana venosa shells were collected during two sampling events from four beaches with different substrate types and wave energy regimes to compare the taphonomic attributes under different environmental conditions. We analyzed the samples by comparing frequencies of taphonomic attributes. Our results show that intermediate-reflective beaches with rocky substrates were dominated by intermediate- to highly fragmented specimens, with high corrasion, intermediate to high bioerosion, low bioencrustation, and medium to large sizes. In contrast, intermediate-dissipative beaches with sandy substrate, mobile stones, and occasional consolidated sediments were dominated by less fragmented shells, high to intermediate corrasion, scarcer bioerosion, low bioencrustation, and small- to medium-sized specimens. Results suggest that significant taphonomic differences arise within two decades under natural conditions. These findings imply that paleoenvironmental signals derived from the taphonomic attributes of fossil assemblages emerge much faster than the potential duration of time averaging of shelly fossils in shallow marine settings.
Diagnostic imaging to locate elements lost during the development of a surgery: A cohort study.
Authors: Susmallian Sergio , Szyper-Kravitz Martine , Folv Eduard , Barnea Royi 
Published: April 2023

Abstract
Object: To corroborate the efficiency of diagnostic images to find missed surgical elements during the course of an operation. Background: Over time, surgery has become more complex, which has increased the risk of events in which surgical items are lost. An incomplete instrumental table inventory can affect patient safety. Material and Methods: Over 6 years, 145 cases of missed surgical items were reported; in 69 (47.6%) cases, a diagnostic image was indicated to search for surgical missed items events (SMIE). Statistical results and significant cases are presented. Mean patients age was 56.81 years old, and 70.7% were female. Results: General surgery was the specialty, and needles were the most frequent items lost. The prevalence of the X-ray image to locate a foreign body was 46.5%, sensitivity was 50%, specificity 100%, and accuracy 76.9%. A total of 14 (21.5%) complications were registered, and no death occurred. In this study, four cases of SMIE are presented to demonstrate a severity of the medical error. Conclusions: An abnormal inventory count and missing objects are indications to conduct diagnostic imaging in the operation room. In the case of a negative X-ray diagnosis, the team should continue searching for the missing object, including re-opening the operating cavity. Clinicaltrials.gov (NCT04293536), date of registration: March 3, 2020.
Estimation Atmospheric parameters for Weather Study and Forecast over Equatorial Regions Using Ground-Based Global Position System
Authors: Yehun Asmamaw Chanie , Kassa Tsegaye , Hunegnaw Addisu , Vermeer Martin 
Published: April 2023

Abstract

There are various models to estimate the neutral atmospheric parameter values, such as in-suite and reanalysis datasets from numerical models. Accurate estimated values of the atmospheric parameters are useful for weather forecasting and climate modeling and monitoring of climate change. Recently, Global Navigation Satellite System (GNSS) measurements have been applied for atmospheric sounding due to its robust data quality and wide horizontal and vertical coverage. The Global Positioning System (GPS) solutions that includes tropospheric parameters constitute a reliable set of data to be assimilated into climate models. The objective of this paper is, to estimate the neutral atmospheric parameters such as Wet Zenith Delay (WZD), Precipitable Water Vapour (PWV) and Total Zenith Delay (TZD) using six selected GPS stations in the equatorial regions, more precisely the Ethiopian GPS stations from 2012 to 2015 observational data. Based on historic estimated GPS-derived values of PWV, we forecasted the PWV from 2015 to 2030. During data processing and analysis, we applied GAMIT-GLOBK software packages to estimate the atmospheric parameters. In the result, we found that the annual averaged minimum values of PWV are 9.72 mm for IISC and maximum 50.37 mm for BJCO stations. The annual averaged minimum values of WZD are 6 cm for IISC and maximum 31 cm for BDMT stations. In the long series of observations (from 2012 to 2015), we also found that there is a trend and cyclic patterns of WZD, PWV and TZD for all stations.
UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury
Authors: Ding Lu , Chu Weiwei , Xia Yu , Ming Shi , Li Tian , Zhou Feng-Quan , Deng David 
Published: April 2023

Abstract
Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult neurogenesis, which is extremely limited in the non-neurogenic spinal cord after injury. Recent evidence suggests that accumulation of protein aggregates impairs the ability of quiescent NSCs to activate. Ubiquitin c-terminal hydrolase l-1 (UCHL1), an important deubiquitinating enzyme in ubiquitin system, plays critical role in removing protein aggregations, but its effects on NSC activation remains unknown. Here, we show that UCHL1 enhances NSC activation by clearing protein aggregates through ubiquitin-proteasome approach. Upregulation of UCHL1 ameliorated the proliferation of spinal cord NSCs after spinal cord injury (SCI). Based on protein microarray analysis of SCI cerebrospinal fluid, it is further revealed that C3+ neurotoxic reactive astrocytes negatively regulated UCHL1 and proteasome activity via C3/C3aR signaling, led to increased abundances of protein aggregations and decreased capacity of NSCs to activate. Furthermore, blockade of reactive astrocytes or C3/C3aR pathway resulted in enhanced NSC activation post-SCI by reserving UCHL1 and proteasome functions. Together, this study elucidated a mechanism regulating NSC activation in the adult spinal cord involving the UCHL1-proteasome approach, which may provide potential molecular targets and new insights for NSC fate regulation.
A novel molecular switch controls assembly of bacterial focal adhesions
Authors: Mignot Tam , Attia Bouchra , My Laetitia , Castaing Jean Philippe , Dinet Celine , Guenno Hugo Le , Schmidt Victoria , Espinosa Leon , Anantharaman Vivek , Aravind L , Sebban-Kreuzer Corinne , Nouailler Matthieu , Bornet Olivier , Viollier Patrick , Elantak Latifa 
Published: April 2023

Abstract
Cell motility is universally driven by focal adhesion complexes (FAs) assembled in the cell envelope to connect the underlying substrate to cytoskeletal motors, generating traction forces in a highly regulated manner. In bacteria, focal adhesion complexes (bFAs) assembly is mediated by the Agl-Glt motility machinery, however how this machinery is connected to the cytoskeleton via cytoplasmic platform proteins, MglA and AglZ, remains unknown. Here, combining in vitro and single cell approaches, we show that the cytoplasmic region of the transmembrane GltJ protein contains two cytosolic motifs that independently recruit MglA-GTP (Linker) and AglZ (GYF), thus driving bFA assembly. Remarkably, binding of MglA-GTP causes a switch in the conformation of an adjacent Zinc finger domain (ZnR) that becomes available to recruit MglB, a MglA GTPase-Activating Protein. This binding activates GTP hydrolysis, which dissociates MglA from GltJ and is important to regulate bFA stability in vivo. These findings thus unravel the molecular mechanism of bFA assembly and regulation. Remarkably, the large number of other bacterial receptor proteins containing adjacent GYF and ZnR domains suggests conservation of this novel type of molecular switches.
Establishment of RT-RPA-Cas12a assay for rapid and sensitive detection of human rhinovirus B
Authors: Li Yongdong , Wang Xuefei , Xu Rong , Wang Ting , Zhang Dandan , qian Weidong 
Published: April 2023

Abstract
Human rhinovirus B (HRV-B) is a major human viral pathogen that can be responsible for various kinds of infections. Due to the health risks associated with HRV-B, it is therefore crucial to explore a rapid, specific, and sensitive method for water quality surveillance. Herein, we exploited a novel detection method for HRV-B by combining reverse-transcription recombinase polymerase amplification (RT-RPA) of nucleic acids isothermal amplification and the trans-cleavage activity of Cas12a. Our RT-RPA-Cas12a-based fluorescent assay can be completed within 35–45 min and obtain a lower detection threshold to 0.5 copies/µL of target RNA. Meanwhile, crRNA sequences without a specific protospacer adjacent motif can effectively activate the trans-cleavage activity of Cas12a. Moreover, our RT-RPA-Cas12a-based fluorescent method was examined using 30 clinical samples, and exhibited high accuracy with positive and negative predictive agreement of 90% and 100%, respectively. Taken together, a novel promising, rapid and effective RT-RPA-Cas12a-based detection method was explored and shows promising potential for on-site HRV-B infection in resource-limited settings.
Whole genome bisulfite sequencing of tumor DNA and matching cfDNA in relapsed pediatric cancer
Authors: Buckley David , Tew Ben , Gooden Gerald , Salhia Bodour 
Published: April 2023

Abstract

Cancer is the second most common cause of death in children aged 1-14 years in the United States, with 11,000 new cases and 1,200 deaths annually. Pediatric cancers typically have lower mutational burden compared to adult-onset cancers; however, the epigenomes of pediatric cancer are highly altered with widespread DNA methylation changes. Currently, whole genome bisulfite sequencing (WGBS) is the most powerful tool for methylome evaluation, but it has been infrequently used to study pediatric cancers. In this we performed WGBS on 34 relapsed pediatric tumors, 13 patient-matched adjacent normal, and 17 patient-matched cell-free (cf)DNA samples from plasma, representing 11 pediatric tumor types. DNA methylation analysis of these cancers revealed differentially methylated regions common to multiple tumor types, which were also detectible in cfDNA and showed potential relevance in multiple adult cancer types. In addition, WGBS data was utilized to estimate copy number alterations (CNAs) and somatic mutations. We also found that tumor associated cfDNA methylation was more sensitive than detection of circulating CNAs and somatic mutations. The resultant pan-cancer cfDNA methylation signature has potential utility in minimal residual disease monitoring and warrants further investigation in both pediatric and adult cancer.
Tooth brushing with fluoridated toothpaste and associated factors among Chinese adolescents: a nationwide cross- sectional study
Authors: Cui Zhiying , Wang Wenhui , Si Yan , Wang Xing , Feng Xiping , Tai Baojun , Hu Deyu , Lin Huancai , Wang Bo , Wang Chunxiao , Zheng Shuguo , Liu Xuenan , Rong Wensheng , Wang Weijian 
Published: April 2023

Abstract
Background: Tooth brushing with fluoridated toothpaste has become the most important way to provide the anti-caries effect of fluoride around the world. China has promoted the use of fluoridated toothpaste since 1989. However, there are few studies on the national profile of use of fluoridated toothpaste and related factors in Chinese adolescents. We carried out this study to investigate oral hygiene behaviours, especially the status of tooth brushing with fluoridated toothpaste and its correlates among adolescents, based on data from the latest Nation Oral Health Survey in mainland China.
Methods: This cross-sectional study recruited 118,601 subjects aged 12-15 years using multistage stratified sampling. Questionnaires were completed by students at school. Data employed in analyses were extracted from the questionnaire, including information on tooth brushing, fluoridated toothpaste, dental floss, sociodemographic factors, fluoride knowledge and attitude towards regular dental care. A binary logistic regression was performed to compute the odds ratios (OR). Tooth brushing twice daily with fluoridated toothpaste was the dependent variable. Sociodemographic factors, fluoride knowledge, attitude towards regular dental care, dental visit experience and perceived oral health were the independent variables. P < 0.05 was considered statistically significant.
Results: A total of 32.6% of subjects brushed their teeth twice daily, 7.4% used fluoridated toothpaste, and 3.9% cleaned their teeth twice daily with fluoridated toothpaste. The logistic regression showed the probability of twice-a-day tooth brushing with fluoridated toothpaste was higher among these groups: females (OR: 1.141; 95%CI: 1.072-1.214), 15-year-olds (OR: 1.786; 95%CI: 1.634-1.952), from urban areas (OR: 1.389; 95%CI: 1.288-1.497), without siblings (OR: 1.351; 95%CI: 1.259-1.450), with an educated father (OR: 1. 605; 95%CI: 1.442-1.788) and mother (OR: 1.706; 95%CI: 1.530-1.903), having dental visit experiences (OR: 1.702; 95%CI: 1.589-1.823), rating one’s oral health as good (OR: 2.341; 95%CI: 2.083-2.631), having fluoride knowledge (OR: 4.345; 95%CI: 4.034-4.678) and having a positive attitude towards regular dental care (OR: 1.589; 95%CI: 1.460-1.729).
Conclusions: The oral hygiene behaviours of Chinese adolescents were undesirable. Twice daily tooth brushing with fluoridated toothpaste was significantly associated with sociodemographic factors, fluoride knowledge, and attitudes towards regular dental care.
Incidence and Determinants of Mortality among Adult Patients Taking Antiretroviral Therapy in Ethiopia: Systematic Review and Meta-Analysis
Authors: Lijalem Habtamu , Workie Shimelash Bitew , Gutulo Muluken Gunta , (professor  , Mazengia Amare Lisanu , Toma Eshetu Hizkeal , Endeshaw Amanual Sisay 
Published: April 2023

Abstract
Reduced AIDS mortality has been linked to the advent of highly active antiretroviral medication. The previous reviews conducted in Ethiopia lack the overall rigor and clarity in the study methodology, reported results and statistical inference. The goal was to create a data summary from studies accomplished previously throughout the nation so that programmers and implementers could use to harmonize the current advanced intervention and direct health service providers to improve ART service provision packages. This data would provide a thorough update on the magnitude of mortality among HIV-infected patients taking HAART by combining 21 eligible articles. The study's heterogeneity, publication bias, and quality were examined. The statistical analysis used random-effects model in STATA version 14. The protocol was registered(CRD42019123380).
As a result, the pooled mortality incidence was 5 per 100 person-years of observation (95% CI: 4–5 per 100 pyo). Two-thirds of deaths occurred within the first year of starting HAART. Clinical stage (Pooled HR = 3.15; 95% CI: 2.36–4.21), CD4 count (Pooled HR = 2.31; 95% CI: 1.83–2.93), hemoglobin level (Pooled HR = 3.05; 95% CI: 2.19–4.27), TB co-infection (Pooled HR = 3.08; 95% CI: 2.21–4.29), and functional status (Pooled HR = 4.86; 95% CI: 3.59–6.97) were factors in this study that were substantially linked to higher mortality. Mortality rates were high, especially early in the therapeutic process. Significant mortality risk factors were WHO clinical stage, CD4 count, poor hemoglobin, TB co-infection, and non-working functional status. This significant mortality rate could be avoided with comprehensive care and stringent monitoring.
The semisynthetic cannabinoid Hexahydrocannabinol (HHC)
Authors: Russo Fabiana , Vandelli Maria Angela , Biagini Giuseppe , Schmid Martin , Luongo Livio , Perrone Michela , Ricciardi Federica , Maione Sabatino , Laganà Aldo , Capriotti Anna Laura , Gallo Alfonso , Carbone Luigi , Perrone Elisabetta , Gigli Giuseppe , Cannazza Giuseppe , Citti Cinzia 
Published: April 2023

Abstract
Cannabis is a double-faced plant with uncountable therapeutic properties, on one side, and controversial psychotropic activities, on the other side, modulated by CB1 endocannabinoid receptors. Δ9-Tetrahydrocannabinol (Δ9-THC) has been identified as the main component responsible for the psychotropic effects, while its isomer cannabidiol (CBD) has shown completely different pharmacological properties. Based on the remarkable beneficial effects, Cannabis has spread worldwide and it is openly sold in shops and online. In order to overcome restrictions due to legal issues, nowadays semi-synthetic derivatives of CBD are often added to cannabis products, obtaining “high” effects similar to those given by Δ9-THC. The first semi-synthetic cannabinoid appeared in the EU was obtained by cyclization and hydrogenation of CBD, and known as hexahydrocannabinol (HHC). At present, very little is known about HHC, its pharmacological properties, and diffusion, since it is not commonly investigated in routine toxicological assays. In the present work, the synthetic strategies aimed to obtain an excess of the active epimer of HHC were investigated and the two epimers were purified and individually tested for their cannabinomimetic activity. Lastly, a simple and fast chromatographic method with a UV detector and a high-resolution mass spectrometer was applied to identify and quantify up to ten major phytocannabinoids, as well as the HHC epimers in commercial cannabis samples.