bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidisciplinary rehabilitation intervention on mobility and hemodynamics of joint contracture animal model
Authors: Maimaiti Palida , Aisilahong Guhaer , Shu Jiao Jiao , Rozi Parhat , Keqike Nuerbiya , Miao Tianyu , Wang Ningning 
Published: April 2023

Abstract
Background
Joint contracture causes a decrease in range of motion (ROM), which severely affects activities of daily living of patients. We have investigated the effectiveness of a multidisciplinary rehabilitation on joint contracture by rat model.

Methods
We used 60 Wistar rats in this study. The rats were divided into five groups as follows: group 1 was the normal control group; except the group 1, we created left hind limb knee joint contracture using Nagai method for other four groups. The joint contracture modeling group 2 was the model control group for monitoring the spontaneous recovery, and other three groups were given different rehabilitation treatments; for example, group 3 was treadmill running group; group 4 was medication group; group 5 was treadmill running plus medication group. The left hind limbs knee joint ROM and the femoral blood flow indicators (FBFI) including PS, ED, RI, and PI were measured right before and after the 4 weeks of rehabilitation.

Result
After 4 weeks of rehabilitation treatments, the measured values of ROM and FBFI are compared with the corresponding values of group 2. Firstly, we did not see clear difference in the values of ROM and FBFI for group 2 before and after 4 weeks spontaneous recovery. The improvement of left lower limb ROM for group 4 and group 5 as compared to the group 2 was statistically significant (p < 0.05), whereas a less recovery for group 3 was observed. However as compared to the group 1, we did not observe full recovery in ROM of group 4 and group 5 after 4 weeks of rehabilitation. The PS and ED level for rehabilitation treatment groups was significantly higher than those modeling ones (Tables 2, 3, Figs. 4, 5), while the RI and PI values show the contrary trends (Tables 4, 5, Figs. 6, 7).

Conclusion
Our results indicate that multidisciplinary rehabilitation treatments had a curative effect on both contracture of joints and the abnormal femoral circulations.
Exploiting the power of UPLC in separation and simultaneous determination of pholcodine, guaiacol along with three specified guaiacol impurities
Authors: Mohamed Hager M. , Zaazaa Hala E. , Abdelkawy M. , Tantawy Mahmoud A. 
Published: April 2023

AbstractPholcodine and guaiacol are widely used together in pharmaceutical syrups for cough treatment. On the other hand, the Ultra Performance Liquid Chromatographic technique is characterized by having the power of increasing chromatographic efficiency and decreasing run time compared to the traditional High Performance Liquid Chromatographic one. In this work, this power was exploited for the simultaneous determination of pholcodine, guaiacol along with three guaiacol impurities, namely; guaiacol impurity A, guaiacol impurity B, and guaiacol impurity E. Good separation was achieved by employing Agilent Zorbax C8 column (50 × 2.1 mm) as the stationary phase, and acetonitrile: phosphate buffer pH 3.5 (40: 60, by volume) as a mobile phase. The proposed method was validated as per International Council for Harmonisation guidelines. Linear relationships, at ranges of 50–1000 µg mL−1 for pholcodine and 5–100 µg mL−1 for guaiacol and the three related impurities, were established. Finally, the proposed method was applied for pholcodine and guaiacol determination in Coughpent® syrup and compared favorably to the reported one.
Experimental feeding of Sergentomyia minuta on reptiles and mammals: comparison with Phlebotomus papatasi
Authors: Ticha Lucie , Volfova Vera , Mendoza-Roldan Jairo Alfonso , Bezerra-Santos Marcos Antonio , Maia Carla , Sadlova Jovana , Otranto Domenico , Volf Petr 
Published: April 2023

Abstract
Background
Sergentomyiaminuta (Diptera: Phlebotominae) is an abundant sand fly species in the Mediterranean basin and a proven vector of reptile parasite Leishmania (Sauroleishmania) tarentolae. Although it feeds preferentially on reptiles, blood meal analyses and detection of Leishmania (Leishmania) infantum DNA in wild-caught S.minuta suggest that occasional feeding may occur on mammals, including humans. Therefore, it is currently suspected as a potential vector of human pathogens.

Methods
A recently established S.minuta colony was allowed to feed on three reptile species (i.e. lizard Podarcissiculus and geckos Tarentolamauritanica and Hemidactylusturcicus) and three mammal species (i.e. mouse, rabbit and human). Sand fly mortality and fecundity were studied in blood-fed females, and the results were compared with Phlebotomuspapatasi, vector of Leishmania (L.) major. Blood meal volumes were measured by haemoglobinometry.

Results
Sergentomyiaminuta fed readily on three reptile species tested, neglected the mouse and the rabbit but took a blood meal on human. However, the percentage of females engorged on human volunteer was low in cage (3%) and feeding on human blood resulted in extended defecation times, higher post-feeding mortality and lower fecundity. The average volumes of blood ingested by females fed on human and gecko were 0.97 µl and 1.02 µl, respectively. Phlebotomuspapatasi females readily fed on mouse, rabbit and human volunteer; a lower percentage of females (23%) took blood meal on the T.mauritanica gecko; reptilian blood increased mortality post-feeding but did not affect P.papatasi fecundity.

Conclusions
Anthropophilic behaviour of S.minuta was experimentally demonstrated; although sand fly females prefer reptiles as hosts, they were attracted to the human volunteer and took a relatively high volume of blood. Their feeding times were longer than in sand fly species regularly feeding on mammals and their physiological parameters suggest that S.minuta is not adapted well for digestion of mammalian blood. Nevertheless, the ability to bite humans highlights the necessity of further studies on S.minuta vector competence to elucidate its potential role in circulation of Leishmania and phleboviruses pathogenic to humans.

Graphical abstract
Geology and stratigraphy of the Neogene section along the Oued Beth between Dar bel Hamri and El Kansera (Rharb Basin, northwestern Morocco) and its otolith-based fish fauna: a faunal inventory for the Early Pliocene remigration into the Mediterranean
Authors: Schwarzhans Werner 
Published: April 2023

AbstractThe coquina on the banks of the Oued Beth in the Rharb Basin in northwestern Morocco has long been known to be exceptionally rich in fossils. The stratigraphic position ranging from the Late Miocene to the Pliocene has been controversial, however. In the course of my master’s degree field work in 1975/76, I mapped the right bank of the Oued Beth from Dar bel Hamri to El Kansera. Following multiple recent studies in the general region, I here review my results and present an updated comprehensive stratigraphic and geologic frame for the first time. The coquina near Dar bel Hamri is interpreted to be of Early Pliocene age, possibly containing some reworking of Late Miocene fossils. The coquina and other locations along the Oued Beth have yielded a rich otolith assemblage, which is described in this article. It represents the first fossil otolith-based fish fauna described from Northwest Africa and contains 96 species, 16 of which are new. The new species in the order of their description are Diaphus maghrebensis n. sp., Ophidion tuseti n. sp., Centroberyx vonderhochti n. sp., Myripristis ouarredi n. sp., Deltentosteus planus n. sp., Caranx rharbensis n. sp., Trachurus insectus n. sp., Parapristipoma bethensis n. sp., Pomadasys zemmourensis n. sp., Cepola lombartei n. sp., Trachinus maroccanus n. sp., Trachinus wernlii n. sp., Uranoscopus hoedemakersi n. sp., Uranoscopus vanhinsberghi n. sp., Spondyliosoma tingitana n. sp., and Opsodentex mordax n. sp. In addition, a new species is described from the Tortonian and Zanclean of Italy: Rhynchoconger carnevalei n. sp. Some additional otoliths are described from another Northwest Moroccan location of Early Pliocene age near Asilah, 50 km south of the Strait of Gibraltar. The Early Pliocene fish fauna from Dar bel Hamri in the Rharb Basin is also of interest, because it constitutes the nearest Atlantic fauna of the time of the reconnection of the Mediterranean with the Atlantic and may have acted as a hosting area for the remigration of fishes into the Mediterranean. Indeed, the correlation is high between the Northwest Moroccan and the well-known time-equivalent Mediterranean fish fauna, but the Moroccan fauna also contains a good proportion of putative endemic taxa and taxa with tropical West African affinities that apparently did not migrate into the Mediterranean. Thus, the Early Pliocene fish fauna from the Rharb Basin represents a unique assemblage for which I propose the biogeographic term “Maghrebian bioprovince.”ZooBank LSID: urn:lsid:zoobank.org:pub:E01D698A-C1EE-4D32-B60D-4EF73AFFFCCFhttps://zoobank.org/65C520AE-72FB-4153-8D18-8695BB5A7E3F
Effect of retirement on medical reimbursement expenses—evidence from China
Authors: Wu Yuanyang , Pang Jiahui , Yang Hualei 
Published: April 2023

Abstract
Background
Medical reimbursement in China is not for all diseases, and medical reimbursement expenses are not completely consistent with medical service demand, though the scope and proportion of medical reimbursement are gradually expanding. This study aimed to examine the effect of retirement on medical reimbursement expenses in urban China.

Methods
The effect of retirement on medical reimbursement expenses were estimated by using fuzzy regression discontinuity based on data from the China Health and Retirement Longitudinal Study (CHARLS) in 2011, 2013, 2015, and 2018. Its group heterogeneity by educational backgrounds and marital status, and underlying mechanisms were also explored.

Results
Retirement increased medical reimbursement expenses of outpatient significantly (P < 0.05).Low time cost and deteriorating health status after retirement were possible mechanisms in this association. Retirement increased the reimbursement expenses significantly among the older adults with more educational obtainment or being widowed/divorced.

Conclusion
The above findings indicated that there was a positive association between retirement and medical reimbursement expenses. The scope and proportion of medical reimbursement should be incorporated into retirement policy for improving medical service accessibility and rational healthcare utilization of retired population.
Changes in intestinal morphology, number of mucus-producing cells and expression of coronavirus receptors APN, DPP4, ACE2 and TMPRSS2 in pigs with aging
Authors: Saleem Waqar , Ren Xiaolei , Van Den Broeck Wim , Nauwynck Hans 
Published: April 2023

AbstractPorcine enteric viral infections cause high morbidity and mortality in young piglets (<3 weeks). Later, these rates decrease with age. This age-dependent infectivity remains largely unexplored. This study investigated the changes in intestinal morphology, number of mucus-producing cells and expression level of coronavirus receptors in three age groups of pigs. Villus height and crypt depth increased with age from 3 days to 3 months in duodenum and ileum but not in mid-jejunum, where the villus height decreased from 580 µm at 3 days to 430 µm at 3 months. Enterocyte length-to-width ratio increased from 3 days to 3 months in all intestinal regions. The number of mucus-producing cells increased with age in the intestinal villi and crypts. The Brunner’s glands of the duodenum contained the highest concentration of mucus-producing cells. The expression of coronavirus receptor APN was highest in the small intestinal villi at all ages. DPP4 expression slightly decreased over time in jejunum and ileum; it was highest in the ileal villi of 3-day-old piglets (70.2% of cells). ACE2 and TMPRSS2 positive cells increased with age in jejunal and ileal crypts and were particularly dominant in the ileal crypts (> 45% of cells). Except for the expression of DPP4 in the jejunum and ileum of young pigs, the expression pattern of the selected coronavirus receptors was very different and not correlated with the age-dependent susceptibility to viral infections. In contrast, the number of mucus-producing cells increased over time and may play an essential role in protecting enteric mucosae against intestinal viruses.
Quaternary ammonium disinfectants and antiseptics: tolerance, resistance and potential impact on antibiotic resistance
Authors: Boyce John M. 
Published: April 2023

Abstract
Background
Due to the substantial increase in the use of disinfectants containing quaternary ammonion compounds (QACs) in healthcare and community settings during the COVID-19 pandemic, there is increased concern that heavy use might cause bacteria to develop resistance to QACs or contribute to antibiotic resistance. The purpose of this review is to briefly discuss the mechanisms of QAC tolerance and resistance, laboratory-based evidence of tolerance and resistance, their occurrence in healthcare and other real-world settings, and the possible impact of QAC use on antibiotic resistance.

Methods
A literature search was conducted using the PubMed database. The search was limited to English language articles dealing with tolerance or resistance to QACs present in disinfectants or antiseptics, and potential impact on antibiotic resistance. The review covered the period from 2000 to mid-Jan 2023.

Results
Mechanisms of QAC tolerance or resistance include innate bacterial cell wall structure, changes in cell membrane structure and function, efflux pumps, biofilm formation, and QAC degradation. In vitro studies have helped elucidate how bacteria can develop tolerance or resistance to QACs and antibiotics. While relatively uncommon, multiple episodes of contaminated in-use disinfectants and antiseptics, which are often due to inappropriate use of products, have caused outbreaks of healthcare-associated infections. Several studies have identified a correlation between benzalkonium chloride (BAC) tolerance and clinically-defined antibiotic resistance. The occurrence of mobile genetic determinants carrying multiple genes that encode for QAC or antibiotic tolerance raises the concern that widespread QAC use might facilitate the emergence of antibiotic resistance. Despite some evidence from laboratory-based studies, there is insufficient evidence in real-world settings to conclude that frequent use of QAC disinfectants and antiseptics has promoted widespread emergence of antibiotic resistance.

Conclusions
Laboratory studies have identified multiple mechanisms by which bacteria can develop tolerance or resistance to QACs and antibiotics. De novo development of tolerance or resistance in real-world settings is uncommon. Increased attention to proper use of disinfectants is needed to prevent contamination of QAC disinfectants. Additional research is needed to answer many questions and concerns related to use of QAC disinfectants and their potential impact on antibiotic resistance.
The impact of country of schooling and gender on secondary school students’ conceptions of and interest in becoming an engineer in Ireland, Kenya and Sweden
Authors: Buckley Jeffrey , Gumaelius Lena , Nyangweso Mercy , Hyland Tomás , Seery Niall , Pears Arnold 
Published: April 2023

Abstract
Background
Given the disparities in gender representation, efforts are needed to make engineering education more inclusive and attractive to young people. It is important that those entering engineering education are making this decision with sufficient understanding of what it means to be an engineer. This study explored how lower secondary education students from Ireland (n = 435), Kenya (n = 436), and Sweden (n = 361) stereotyped engineers, and their interest in becoming an engineer was examined. The Draw an Engineer Test was used to achieve this, and ordinal and logistic regression analyses were conducted to compare the effects of students’ genders and country of schooling on the genders and concepts of their drawn engineers, and on their interest in becoming an engineer in the future.

Results
A Sankey diagram illustrated significant complexity in the interaction between conceptions of engineering work and fields of engineering. Chi-square tests of association were used to examine the association between students depicting an engineer as either the same or a different gender to themselves and their interest in becoming an engineer. The results of these and the regression analyses indicate that young people’s gender explains more variance in the gender of drawn engineers and the country they are studying in explains more variance in their conception of engineers. However, most variance was explained when both students’ gender and country of study were considered together. Further, particularly for young females, drawing a female engineer as opposed to a male engineer was positively associated with increased interest in becoming an engineer.

Conclusions
There is a need to develop a greater understanding of engineering in young people to ensure they have sufficient information to make decisions regarding related educational pursuits. National-level attempts are needed to present accurate depictions of engineering, and effort needs to be invested in ensuring that young females can identify as engineers. Higher educational access needs to be considered in future work examining future career interests.
Challenges and opportunities for increasing patient involvement in heart failure self-care programs and self-care in the post–hospital discharge period
Authors: Butler Javed , Petrie Mark C. , Bains Marc , Bawtinheimer Tracy , Code Jillianne , Levitch Teresa , Malvolti Elmas , Monteleone Pasquale , Stevens Petrina , Vafeiadou Jenny , Lam Carolyn S. P. 
Published: April 2023

Abstract
Background
People living with heart failure (HF) are particularly vulnerable after hospital discharge. An alliance between patient authors, clinicians, industry, and co-developers of HF programs can represent an effective way to address the unique concerns and obstacles people living with HF face during this period. The aim of this narrative review article is to discuss challenges and opportunities of this approach, with the goal of improving participation and clinical outcomes of people living with HF.

Methods
This article was co-authored by people living with HF, heart transplant recipients, patient advocacy representatives, cardiologists with expertise in HF care, and industry representatives specializing in patient engagement and cardiovascular medicine, and reviews opportunities and challenges for people living with HF in the post–hospital discharge period to be more integrally involved in their care. A literature search was conducted, and the authors collaborated through two virtual roundtables and via email to develop the content for this review article.

Results
Numerous transitional-care programs exist to ease the transition from the hospital to the home and to provide needed education and support for people living with HF, to avoid rehospitalizations and other adverse outcomes. However, many programs have limitations and do not integrally involve patients in the design and co-development of the intervention. There are thus opportunities for improvement. This can enable patients to better care for themselves with less of the worry and fear that typically accompany the transition from the hospital. We discuss the importance of including people living with HF in the development of such programs and offer suggestions for strategies that can help achieve these goals. An underlying theme of the literature reviewed is that education and engagement of people living with HF after hospitalization are critical. However, while clinical trial evidence on existing approaches to transitions in HF care indicates numerous benefits, such approaches also have limitations.

Conclusion
Numerous challenges continue to affect people living with HF in the post–hospital discharge period. Strategies that involve patients are needed, and should be encouraged, to optimally address these challenges.
Victim blaming, prior history to sexual victimization, support for sexually assaulted friends, and rape myths acceptance as predictors of attitudes towards rape victims in the general population of Pakistan
Authors: Kazmi Syed Messum Ali , Tarar Amina Hanif , Nasir Awais , Iftikhar Rabia 
Published: April 2023

Abstract
Background
Individuals who have been sexually assaulted often turn to their friends for comfort and support. Responses to such disclosures vary greatly and may be influenced by prior victimization, the relationship of the disclosure recipient to the accused, and the recipient’s acceptance of rape myths. Moreover, currently there are no studies to date that have validated the Illinois Rape Myths Acceptance Model in Pakistan.

Method
To gain a better understanding of this phenomenon, the online survey was administered to the general population. Of this sample, 512 (consisting of 312 females and 200 males) reported having received a rape disclosure from a friend.

Results
The results showed that having lower scores on rape myths acceptance (being less likely to endorse rape myths) was significantly associated with positive attitudes towards rape victims. Similarly, being female, having graduate or above level education, not blaming the victim, having prior history of sexual victimization, offering support for friends experiencing sexual assault, and being liberal were significantly associated with positive attitudes towards rape victims. Additionally, confirmatory factor analysis of the Illinois Rape Myths Acceptance Scale showed acceptable model fit indices and relevance to the Pakistani context.

Conclusion
In conclusion, it has been assessed through the results that showed that having lower scores on rape myths acceptance (being less likely to endorse rape myths) was significantly associated with positive attitudes towards rape victims. Similarly, being female, having graduate or above level education, not blaming the victim, having prior history of sexual victimization, offering support for friends experiencing sexual assault, and being liberal were significantly associated with positive attitudes towards rape victims. It is further concluded that having experienced sexual victimization leads individuals towards showing empathy to rape victims and thus may influence them to provide support for such victims. The findings further show that Illinois Rape Myths Acceptance is a valid measure for measurement of rape myths in Pakistan as established through the acceptable model fit indices. With the use of validated scales, we could gain a better understanding of rape and the factors related to it, which could be used to inform practices and policy decisions.