bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mechanisms underlying cyclophosphamide-induced cognitive impairment and strategies for neuroprotection in preclinical models
Authors: Ibrahim Kamilia M. , Darwish Samar F. , Mantawy Eman M. , El-demerdash Ebtehal 
Published: July 2023

AbstractCyclophosphamide has drastically enhanced the expectancy and quality of life of cancer patients. However, it is accompanied by diverse neurological complications which are considered a dose-limiting adverse effect. Neurotoxicity caused by cyclophosphamide can manifest in numerous manners including anxiety, depression, motor dysfunction and cognitive deficits. This review article offers an overview on cyclophosphamide-induced neurotoxicity, providing a unified point of view on the possible underlying molecular mechanisms including oxidative brain damage, neuroinflammation, apoptotic neuronal cell death as well as disruption of the balance of brain neurotransmitters and neurotrophic factors. Besides, this review sheds light on the promising protective agents that have been investigated using preclinical animal models as well as their biological targets and protection mechanisms. Despite promising results in experimental models, none of these agents has been studied in clinical trials. Thus, there is lack of evidence to advocate the use of any neuroprotective agent in the clinical setting. Furthermore, none of the protective agents has been evaluated for its effect on the anticancer activity of cyclophosphamide in tumor-bearing animals. Therefore, there is a great necessity for adequate well-designed clinical studies for evaluation of the therapeutic values of these candidates. Conclusively, this review summarizes the molecular mechanisms accounting for cyclophosphamide-induced neurotoxicity together with the potential protective strategies seeking for downgrading this neurological complication, thus enhancing the quality of life and well-being of cancer patients treated with cyclophosphamide.
Graphical abstract
Molecular classification of urothelial bladder carcinoma
Authors: Schwarzova Lucia , Varchulova Novakova Zuzana , Danisovic Lubos , Ziaran Stanislav 
Published: July 2023

AbstractUrothelial bladder carcinoma (UC) ranks among the top ten most commonly diagnosed cancers worldwide on an annual basis. The standardized classification system for urothelial bladder tumors is the Tumor, Node, Metastasis classification, which reflects differences between non-muscle-invasive bladder carcinoma (NMIBC) and muscle-invasive bladder carcinoma (MIBC) and it depends on the extent to which tumor has infiltrated the bladder wall and other tissues and organs. NMIBC and MIBC exhibit great intrinsic heterogeneity regarding different prognoses, survival, progression, and treatment outcomes. In recent years, studies based on mRNA expression profiling revealed the existence of biologically relevant molecular subtypes of UC, which show variant molecular features that can provide more precise stratification of UC patients. Here, we present a complex classification of UC based on mRNA expression studies and molecular subtypes of NMIBC and MIBC in detail with regard to different mRNA expression profiles, mutational signatures, and infiltration by non-tumor cells. The possible impact of molecular subtyping on treatment decisions and patients’ outcomes is outlined, too.
The Geochemical Legacy of Low-Temperature, Percolation-Driven Core Formation in Planetesimals
Authors: Bromiley Geoffrey David 
Published: July 2023

AbstractMechanisms for core formation in differentiated bodies in the early solar system are poorly constrained. At temperatures below those required to extensively melt planetesimals, core formation could have proceeded via percolation of metallic liquids. Although there is some geochemical data to support such ‘low-temperature’ segregation, experimental studies and simulations suggest that percolation-driven segregation might have only contributed to core formation in a proportion of fully-differentiated bodies. Here, the effects low-temperature core-formation on elemental compositions of planetesimal cores and mantles are explored. Immiscibility of Fe-rich and FeS-rich liquids will occur in all core-formation models, including those involving large fraction silicate melting. Light element content of cores (Si, O, C, P, S) depends on conditions under which Fe-rich and FeS-rich liquids segregated, especially pressure and oxygen fugacity. The S contents of FeS-rich liquids significantly exceed eutectic compositions in Fe–Ni–S systems and cannot be reconciled with S-contents of parent bodies to magmatic iron meteorites. Furthermore, there is limited data on trace element partitioning between FeS-rich and Fe-rich phases, and solid/melt partitioning models cannot be readily applied to FeS-rich liquids. Interaction of metallic liquids with minor phases stable up to low fraction silicate melting could provide a means for determining the extent of silicate melting prior to initiation of core-formation. However, element partitioning in most core-formation models remains poorly constrained, and it is likely that conditions under which segregation of metallic liquid occurred, especially oxygen fugacity and pressure, had as significant a control on planetesimal composition as segregation mechanisms and extent of silicate melting.
Estimating the disutility of relapse in relapsing–remitting and secondary progressive multiple sclerosis using the EQ-5D-5L, AQoL-8D, EQ-5D-5L-psychosocial, and SF-6D: implications for health economic evaluation models
Authors: Ahmad Hasnat , Campbell Julie A. , van der Mei Ingrid , Taylor Bruce V. , Xia Qing , Zhao Ting , Palmer Andrew J. 
Published: July 2023

Abstract
Background and aims
Relapses are an important clinical feature of multiple sclerosis (MS) that result in temporary negative changes in quality of life (QoL), measured by health state utilities (HSUs) (disutilities). We aimed to quantify disutilities of relapse in relapsing remitting MS (RRMS), secondary progressive MS (SPMS), and relapse onset MS [ROMS (including both RRMS and SPMS)] and examine these values by disability severity using four multi-attribute utility instruments (MAUIs).

Methods
We estimated (crude and adjusted and stratified by disability severity) disutilities (representing the mean difference in HSUs of ‘relapse’ and ‘no relapse’ groups as well as ‘unsure’ and ‘no relapse’ groups) in RRMS (n = 1056), SPMS (n = 239), and ROMS (n = 1295) cohorts from the Australian MS Longitudinal Study’s 2020 QoL survey, using the EQ-5D-5L, AQoL-8D, EQ-5D-5L-Psychosocial, and SF-6D MAUIs.

Results
Adjusted mean overall disutilities of relapse in RMSS/SPMS/ROMS were − 0.101/− 0.149/− 0.129 (EQ-5D-5L), − 0.092/− 0.167/− 0.113 (AQoL-8D), − 0.080/− 0.139/− 0.097 (EQ-5D-5L-Psychosocial), and − 0.116/− 0.161/− 0.130 (SF-6D), approximately 1.5 times higher in SPMS than in RRMS, in all MAUI. All estimates were statistically significant and/or clinically meaningful. Adjusted disutilities of RRMS and ROMS demonstrated a U-shaped relationship between relapse disutilities and disability severity. Relapse disutilities were higher in ‘severe’ disability than ‘mild’ and ‘moderate’ in the SPMS cohort.

Conclusion
MS-related relapses are associated with substantial utility decrements. As the type and severity of MS influence disutility of relapse, the use of disability severity and MS-type-specific disutility inputs is recommended in future health economic evaluations of MS. Our study supports relapse management and prevention as major mechanisms to improve QoL in people with MS.
Design Space Exploration for Partitioning Dataflow Program on CPU-GPU Heterogeneous System
Authors: Bloch Aurelien , Casale-Brunet Simone , Mattavelli Marco 
Published: July 2023

AbstractDataflow programming is a methodology that enables the development of high-level, parametric programs that are independent of the underlying platform. This approach is particularly useful for heterogeneous platforms, as it eliminates the need to rewrite application software for each configuration. Instead, it only requires new low-level implementation code, which is typically automatically generated through code generation tools. The performance of programs running on heterogeneous parallel platforms is highly dependent on the partitioning and mapping of computation to different processing units. This is determined by parameters that govern the partitioning, mapping, scheduling, and allocation of data exchanges among the processing elements of the platform. Determining the appropriate parameters for a specific application and set of architectures is a complex task and is an active area of research. This paper presents a novel methodology for partitioning and mapping dataflow programs onto heterogeneous systems composed of both CPUs and GPUs. The objective is to identify the program configuration that provides the most efficient way to process a typical dataflow program by exploring its design space. This is an NP-complete problem that we have addressed by utilizing a design space exploration approach that leverages a Tabu search meta-heuristic optimization algorithm driven by analysis of the execution trace graph of the program. The heuristic algorithm effectively identifies a solution that maps actors to processing units while improving overall performance. The parameters of the heuristic algorithm, such as the time limit and the proportion of neighboring solutions explored during each iteration, can be fine-tuned for optimal results. Additionally, the proposed approach allows for the exploration of solutions that do not utilize all hardware resources if it results in better performance. The effectiveness of the proposed approach is demonstrated through experimental results on dataflow programs.
Time-resolved triggering and runout analysis of rainfall-induced shallow landslides
Authors: La Porta G. , Leonardi A. , Pirulli M. , Cafaro F. , Castelli F. 
Published: July 2023

AbstractRainfall-induced shallow landslides often turn into flows. These phenomena occur worldwide and pose severe hazard to infrastructure and human lives on mountainous areas. Risk assessment, and the design of mitigation measures, can both be informed by back-analysis of previous events. However, shallow instabilities are frequently spread over a large area, with the generated flows occurring in sequences, or surges. Conventionally, back-analysis exercises tackle the problem by simulating runout as a single event, with all surges happening simultaneously. This simplification has repercussions that have not been explored in the literature so far, and whose impact in hazard assessment practice is unclear. Therefore, a novel time-resolving procedure is proposed in this paper, which can for the first time be applied to resolve instability sequences of arbitrary duration. The methodology discretizes the event, detecting instabilities at equally spaced time intervals as a function of rainfall. Thanks to this, the post-failure behaviour of each surge can be tracked by a runout model, with a separate simulation performed every time a new instability is detected. The methodology robustness is tested on two documented case studies. The results reveal that, under some conditions, the time-resolving procedure can lead to significantly different results in terms of runout path, flooded area, and flow heights. This leads to criticism on how back-analysis is conventionally applied, prompting for a review of historical cases.
A Comprehensive Survey of Silicon Thin-film Solar Cell: Challenges and Novel Trends
Authors: ElKhamisy Khalil , Abdelhamid Hamdy , El-Rabaie El-Sayed M. , Abdel-Salam Nariman 
Published: July 2023

AbstractSolar cells are commonly recognized as one of the most promising devices that can be utilized to produce energy from renewable sources. As a result of their low production costs, little material consumption, and projected increasing trajectory in terms of efficiency, thin-film solar cells have emerged as the technology of choice in the solar industry at present. This study aims to provide a comprehensive review of silicon thin-film solar cells, beginning with their inception and progressing up to the most cutting-edge module made in a laboratory setting. There is a review of the fantastic development of each technology, as well as its cell configuration, restrictions, equivalent circuit model, cell performance, and global market share. The dependability and availability of cell materials, in addition to the comparison of numerous characteristics, are both areas of research that are conducted concurrently for each of the distinct technologies. New advances in solar cells are also highlighted; these hold the potential to be significant variables and solutions in the process of the future's development. This abbreviated and brief version of the comprehensive analysis is provided to readers in the hope that it will aid them in evaluating potential research avenues about the proper applications and production of solar cells.
Säkularität im Schwimmbad. Einstellungen zu eigenen und fremden Körperpraktiken
Authors: Michalowski Ines 
Published: July 2023

ZusammenfassungDie Studie untersucht die Aushandlung von Säkularität in öffentlichen Organisationen anhand des Beispiels von Körperpraktiken im Schwimmbad. Gefragt wird, inwiefern es durch das Aufkommen des Burkinis zu einer Neuaushandlung der Rolle von Religion im eigentlich als komplett säkular wahrgenommenen Schwimmbad kommt. Analysiert werden 101 kurze Interviews mit Badegästen im Schwimmbad. Die Datenanalyse zeigt, dass eigene Körperpraktiken vor allem mit Verweis auf Einhaltung der Mehrheitsnorm legitimiert werden. Bei Abweichung von der Norm kommen funktionale und teils wertebezogene Argumente zum Tragen. Die Befürwortung fremder Körperpraktiken, die sich wie beispielsweise der Burkini von den eigenen unterscheiden, wird aber anders, nämlich unter Bezug auf höhere Werte wie Diversität oder Selbstbestimmung legitimiert. Ein mit eigenen Erfahrungen verbundenes Nachempfinden religiös motivierter Körperscham konnte unter den hier befragten nichtmuslimischen Personen nicht beobachtet werden. Theoretisch liefert der Aufsatz einen Beitrag zu der Literatur über das Verhältnis zwischen säkularem und religiösem Körper, indem er verdeutlicht, dass die wahrgenommene Irrationalität religiös genormter Körperpraktiken nicht durch Verständnis, sondern durch wertebasierte Toleranz bearbeitet wird. Die Studie diskutiert zudem die Rolle von Organisationsregeln für die Ermöglichung religiöser Körperpraktiken sowohl hinsichtlich ihrer Fähigkeiten als auch Grenzen, die vor allem in den Reaktionen der Nutzerschaft begründet liegen.
Characteristics of Clostridioides difficile isolates circulating in the Slovak hospitals
Authors: Toporová Annamária , Čurová Katarína , Novotný Martin , Lovayová Viera , Nagyová Mária , Siegfried Leonard , Takáčová Viktória , Lišková Anna , Longauerová Andrea , Vukušičová Uhrinová Michaela , Dzugasová Barbora 
Published: July 2023

AbstractClostridioides difficile is a frequent cause of hospital-acquired diarrhea associated with antibiotics. Hypervirulent strains of Clostridioides difficile are associated with a severe course of Clostridioides difficile infection and a higher mortality. We have confirmed 322 non-duplicate Clostridioides difficile isolates in stool samples of patients hospitalized in three Slovak hospitals providing primary health care between January and December 2021 and determined genes encoding toxins, ribotypes and susceptibility to antimicrobials. 93.7% of them were toxigenic and co-occurrence of genes tcdA, tcdB, cdtA, cdtB, which encode toxins, was detected in 71.4% isolates. Nosocomially associated ribotypes 176, 001, and 027 were confirmed in 61.1%, 10.2%, and 5.2% of isolates, respectively, and found to be the most frequent. Although ribotype 176 predominated in all three hospitals, the highest incidence was recorded in Košice (73.5%). Results of antimicrobial susceptibility testing revealed 65.8% resistance rate for rifampicin, 5.2% for vancomycin, 1.5% for metronidazole, 1.2% for teicoplanin and 0.6% for doxycycline. The correlation of frequent ribotypes and results of antimicrobial susceptibility testing points to the predominance of rifampicin resistance in isolates belonging to ribotypes 176 and 027. The above results reflect the problematic situation in our hospitals during the COVID-19 pandemic, that was related to the misuse of broad-spectrum antibiotics and impossibility to follow epidemiological measures to prevent the spread of hypervilulent isolates.
Thinking magically or thinking scientifically: Cognitive and belief predictors of complementary and alternative medicine use in women with and without cancer diagnosis
Authors: Čavojová Vladimíra , Kaššaiová Zuzana , Šrol Jakub , Ballová Mikušková Eva 
Published: July 2023

AbstractThis paper examines the predictors of belief in the efficacy of complementary and alternative medicine (CAM) and its use, including cognitive factors (scientific reasoning, health literacy, locus of control), beliefs (holistic and magical health beliefs pseudoscientific beliefs, and trust in doctors), sociodemographic factors, and cancer diagnosis. The sample consisted of 177 women (41.8% with a cancer diagnosis; Mage = 38.81, SD = 11.43). Beliefs in efficacy and use of CAM were the main outcome measures; preference for CAM over conventional treatment was a secondary outcome measure. Pseudoscientific/magical beliefs and external locus of control were the strongest predictors of positive attitudes toward CAM and its higher use, as well as preference for CAM instead of conventional treatment. Cancer diagnosis predicted only higher CAM use, but not more positive attitudes to CAM, nor preference for CAM instead of conventional medicine. Women with cancer had significantly more pseudoscientific beliefs than women without cancer and had a higher external locus of control over their health. Women with pseudoscientific/magical beliefs favor CAM treatments independently of the cancer diagnosis, although the diagnosis of cancer also contributes to their higher use of CAM. In other words, it seems improbable that women would turn toward CAM treatment only after being diagnosed with cancer.
Women’s avoidant attachment, conflict solving, and relationship satisfaction through individualism and masculinity
Authors: Bretaña Ione , Alonso-Arbiol Itziar , Lavy Shiri , Zhang Fang 
Published: July 2023

AbstractThe utilization of specific strategies to manage couple conflict has a differential impact on women’s relationship satisfaction. However, considering that women’s role within couple relationship is shaped by societal norms, such association should be examined by embracing a cross-cultural perspective. Thus, the objective of this study is to analyze the effect of individualism/collectivism and masculinity/femininity cultural values on avoidant attachment, perceived conflict solving, and relationship satisfaction. The sample consisted of 334 women from Israel, USA, Türkiye, and Spain. An unconstrained general model elucidates the connections among relationship satisfaction, avoidant attachment, and conflict solving strategies across all countries; yet, the strength of certain associations varies based on the dimensions of masculinity and individualism. In individualistic countries, avoidant attachment predicts lower relationship satisfaction in women. The prediction of own withdrawal by avoidant attachment remains similar among women, regardless of the individualism dimension. Nevertheless, in feminine (i.e., role egalitarian) countries, the link between female’s avoidant attachment and their partner’s use of positive conflict solving strategies is stronger. Additionally, the withdrawal strategy predicts partner demand to a greater extent in women from feminine countries. These findings will assist professionals from different countries in developing culturally sensitive and tailored prevention and intervention tools.
Space-time dynamics of cargo theft: evidence from São Paulo, Brazil
Authors: Aransiola Temidayo James , Justus Marcelo , Ceccato Vania 
Published: July 2023

AbstractThe objective of this study is to contribute to the growing literature on cargo theft by empirically testing four specific hypotheses of its causes – the space-time dynamics hypothesis, the economic attractiveness hypothesis, the social structure hypothesis, and the deterrence hypothesis. This study investigates the case of the economic core of one of the most severe regions regarding cargo theft worldwide – São Paulo state. As novelty in crime studies, we estimate Autorrregressive Distributed Lag models (ARDL). We found that the number of cargo thefts of a geographic area can be predicted by itself and that of neigbouring areas. This is an unprescendeted empirical evidence that cargo theft time series are autoregressive and cointegrated. Regarding economic attractiveness and social structure, the results are inconclusive. However, police activity reduces cargo theft in the large metropolitan area and inland municipalities of São Paulo state.
Social Categorisation and Social Identification: The Mediating Role of Social Isolation and Loneliness in Adolescents Living with HIV
Authors: Ngwenya Nothando , Smith Thandeka , Shahmanesh Maryam , Psaros Christina , Munikwa Chiedza , Nkosi Khethokuhle , Seeley Janet 
Published: July 2023

Abstract
Background
Social isolation and loneliness are associated with living with a chronic condition particularly where stigma is a factor. Our study aimed to examine the lived experience of adolescents living with HIV in relation to isolation because of their diagnosis and consequences of disclosure. Giddens’ structuration theory was used as an analytic framework to identify the potential mechanisms underlying adolescents living with HIV’s experiences.

Method
Longitudinal in-depth interviews were conducted with 20 adolescents living with HIV aged 15–24 years with each participant taking part in three interviews (total 60) between September 2020 and October 2021. Thematic analysis was performed using Braun and Clarke’s steps for coding and analysing qualitative data and informed by the structuration theory framework.

Results
The findings indicated that adolescents living with HIV have agency and make conscious choices about sharing their status. However, these choices are influenced by their experiences in their community. The discrimination and negative judgements they often experience prevent them from disclosing their status. Stigma, discrimination, and psychological distress contribute to the isolation that adolescents and young adults living with HIV experience. The limited disclosure itself can lead to them becoming isolated and lonely.

Conclusion
The negative experiences which adolescents living with HIV face can have an impact not only on their psychological wellbeing but also on their decision to disclose and seek support. These experiences may lead to social isolation and loneliness, an unintended consequence of their action in protecting themselves from the conditions created by the structures/environment in which they live.