bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accessing chiral-even quark generalised parton distributions in the exclusive photoproduction of a γπ± pair with large invariant mass in both fixed-target and collider experiments
Authors: Duplančić Goran , Nabeebaccus Saad , Passek-Kumerički Kornelija , Pire Bernard , Szymanowski Lech , Wallon Samuel 
Published: March 2023

Abstract
We compute the exclusive photoproduction of a γπ± pair using the collinear factorisation framework, in the kinematic regime where the pair has a large invariant mass and the meson has a sufficiently large transverse momentum to not resonate with the outgoing nucleon. This exclusive channel presents a new avenue for the investigation of GPDs. It is particularly interesting as the high centre of mass energies available at future experiments will allow the study of GPDs at small skewness ξ. We compute the scattering amplitude of the process, at leading twist and leading order in αs, which is used to estimate its cross-section and linear polarisation asymmetries with respect to the incoming photon, for JLab 12-GeV, COMPASS, future EIC and LHC (in ultra-peripheral collisions) kinematics. We find that the order of magnitude of estimates are sufficiently large for a dedicated experimental analysis to be performed, especially at JLab. We also compare the results from an asymptotic distribution amplitude (DA) to those using a recently proposed holographic DA.
SEMA6C: a novel adhesion-independent FAK and YAP activator, required for cancer cell viability and growth
Authors: Fard Damon , Testa Erika , Panzeri Valentina , Rizzolio Sabrina , Bianchetti Giada , Napolitano Virginia , Masciarelli Silvia , Fazi Francesco , Maulucci Giuseppe , Scicchitano Bianca Maria , Sette Claudio , Viscomi Maria Teresa , Tamagnone Luca 
Published: March 2023

AbstractTransmembrane semaphorins are signaling molecules, controlling axonal wiring and embryo development, which are increasingly implicated in human diseases. Semaphorin 6C (Sema6C) is a poorly understood family member and its functional role is still unclear. Upon targeting Sema6C expression in a range of cancer cells, we observed dramatic growth suppression, decreased ERK phosphorylation, upregulation of cell cycle inhibitor proteins p21, p27 and p53, and the onset of cell senescence, associated with activation of autophagy. These data are consistent with a fundamental requirement for Sema6C to support viability and growth in cancer cells. Mechanistically, we unveiled a novel signaling pathway elicited by Sema6C, and dependent on its intracellular domain, mediated by tyrosine kinases c-Abl and Focal Adhesion Kinase (FAK). Sema6C was found in complex with c-Abl, and induced its phosphorylation, which in turn led to FAK activation, independent of cell–matrix adhesion. Sema6C-induced FAK activity was furthermore responsible for increased nuclear localization of YAP transcriptional regulator. Moreover, Sema6C conferred YAP signaling-dependent long-term cancer cell survival upon nutrient deprivation. In conclusion, our findings demonstrate that Sema6C elicits a cancer promoting-signaling pathway sustaining cell viability and self-renewal, independent of growth factors and nutrients availability.
Detection of gases and organic vapors by cellulose-based sensors
Authors: Pena-Pereira Francisco , Lavilla Isela , de la Calle Inmaculada , Romero Vanesa , Bendicho Carlos 
Published: March 2023

AbstractThe growing interest in the development of cost-effective, straightforward, and rapid analytical systems has found cellulose-based materials, including cellulose derivatives, cellulose-based gels, nanocellulosic materials, and the corresponding (nano)cellulose-based composites, to be valuable platforms for sensor development. The present work presents recent advances in the development of cellulose-based sensors for the determination of volatile analytes and derivatives of analytical relevance. In particular, strategies described in the literature for the fabrication and modification of cellulose-based substrates with responsive materials are summarized. In addition, selected contributions reported in the field of paper-based volatile sensors are discussed, with a particular emphasis on quick response (QR) code paper-based platforms, intelligent films for food freshness monitoring, and sensor arrays for volatile discrimination purposes. Furthermore, analytical strategies devised for the determination of ionic species by in situ generation of volatile derivatives in both paper-based analytical devices (PADs) and microfluidic PADs will also be described.
Graphical abstract
Therapeutic perspective for children and young adults living with thalassemia and sickle cell disease
Authors: Ferraresi Marta , Panzieri Daniele Lello , Leoni Simona , Cappellini Maria Domenica , Kattamis Antonis , Motta Irene 
Published: March 2023

Abstract
Hemoglobinopathies, including thalassemias and sickle cell disease, are the most common monogenic diseases worldwide, with estimated annual births of more than 330,000 affected infants. Hemoglobin disorders account for about 3.4% of deaths in children under 5 years of age. The distribution of these diseases is historically linked to current or previously malaria-endemic regions; however, immigration has led to a worldwide distribution of these diseases, making them a global health problem. During the last decade, new treatment approaches and novel therapies have been proposed, some of which have the potential to change the natural history of these disorders. Indeed, the first erythroid maturation agent, luspatercept, and gene therapy have been approved for beta-thalassemia adult patients. For sickle cell disease, molecules targeting vaso-occlusion and hemoglobin S polymerization include crizanlizumab, which has been approved for patients ≥ 16 years, voxelotor approved for patients ≥ 12 years, and L-glutamine for patients older than 5 years. Conclusion: We herein present the most recent advances and future perspectives in thalassemia and sickle cell disease treatment, including new drugs, gene therapy, and gene editing, and the current clinical trial status in the pediatric populations.

What is Known:• Red blood cell transfusions, iron chelation therapy and hematopoietic stem cell transplantation have been the mainstay of treatment of thalassemia patients for decades.• For sickle cell disease, until 2005, treatment strategies were mostly the same as those for thalassemia, with the option of simple transfusion or exchange transfusion. In 2007, hydroxyurea was approved for patients ≥ 2 years old.

What is New:• In 2019, gene therapy with betibeglogene autotemcel (LentiGlobin BB305) was approved for TDT patients ≥ 12 years old non β0/β0 without matched sibling donor.• Starting from 2017 several new drugs, such as L-glutamine (approved only by FDA), crizanlizumab (approved by FDA and EMA for patients ≥ 16 years), and lastly voxelotor (approved by FDA and EMA for patients ≥ 12 years old).
Pazopanib with Topotecan weekly for patients with platinum-resistant or intermediate-sensitive recurrent ovarian cancer: results of a multicentre, open label phase I/II study (TOPAZ)
Authors: Chekerov Radoslav , Arndt Tjadina , Pietzner Klaus , Canzler Ulrich , Wimberger Pauline , Strauß Hans-Georg , Mahner Sven , Woelber Linn , de Gregorio Nikolaus , Stocker Gertraud , von Abel Ekkehard , Neunhoeffer Tanja , Belau Antje Kristina , Mustea Alexander , Yalinkaya Isil , Braicu Elena Ioana , Richter Rolf , Sehouli Jalid ,   for the NOGGO ovarian cancer study group
Published: March 2023

Abstract
Purpose
Pazopanib has promising antiangiogenetic activity in solid cancers. The investigator-initiated phase I/II trial evaluated the combination of Topotecan with Pazopanib in platinum-resistant or intermediate-sensitive recurrent ovarian cancer (ROC).

Methods
Patients (≥ 18 years) with first or second recurrence were enrolled in this multicentre open-label trial. Phase I analysed Topotecan 4 mg/m2 (day 1, 8, 15, ever 28 days) for six cycles to identify the maximum tolerated dose (MTD) of Pazopanib added in a dose-escalating scheme with 400 mg starting dose. The phase II analysed safety and efficacy aspects. For all patients with clinical remission a maintenance with Pazopanib until progression was allowed. This trial is registered with ClinicalTrials.gov, number NCT 01600573.

Results
Between June 2012 and February 2017, 11 patients were enrolled in the phase I, and 50 patients in the phase II study. The MTD of Pazopanib was determined by 400 mg/daily. Haematological and liver toxicities determined the dose limiting toxicities (DLT) and the most common grade 3–4 adverse events: leucopenia (25%), neutropenia (22%), thrombocytopenia (19%), accumulation of cholestatic (20%) and hepatocellular damage (15%), which often caused dose modifications, but no new life-threatening events. Overall response was 16% and clinical benefit rate 68%. Median progression-free survival (PFS) was 3.5 months (95% CI 2.0—5.0). Due to early progression only 20% of the patients were able to start with maintenance treatment.

Conclusion
The combination of pazopanib and weekly topotecan is feasible, resulting in a manageable haematological and liver toxicity, but despite its encouraging response rate, was not associated with a significant survival benefit.
Boolean finite cell method for multi-material problems including local enrichment of the Ansatz space
Authors: Petö Márton , Eisenträger Sascha , Duvigneau Fabian , Juhre Daniel 
Published: March 2023

AbstractThe Finite Cell Method (FCM) allows for an efficient and accurate simulation of complex geometries by utilizing an unfitted discretization based on rectangular elements equipped with higher-order shape functions. Since the mesh is not aligned to the geometric features, cut elements arise that are intersected by domain boundaries or internal material interfaces. Hence, for an accurate simulation of multi-material problems, several challenges have to be solved to handle cut elements. On the one hand, special integration schemes have to be used for computing the discontinuous integrands and on the other hand, the weak discontinuity of the displacement field along the material interfaces has to be captured accurately. While for the first issue, a space-tree decomposition is often employed, the latter issue can be solved by utilizing a local enrichment approach, adopted from the extended finite element method. In our contribution, a novel integration scheme for multi-material problems is introduced that, based on the B-FCM formulation for porous media, originally proposed by Abedian and Düster (Comput Mech 59(5):877–886, 2017), extends the standard space-tree decomposition by Boolean operations yielding a significantly reduced computational effort. The proposed multi-material B-FCM approach is combined with the local enrichment technique and tested for several problems involving material interfaces in 2D and 3D. The results show that the number of integration points and the computational time can be reduced by a significant amount, while maintaining the same accuracy as the standard FCM.
Overcoming biases and identifying opportunities for citizen science to contribute more to global macroinvertebrate conservation
Authors: Deacon Charl , Govender Suvania , Samways Michael J. 
Published: March 2023

AbstractCitizen Science (CS) provides valuable data to assist professional scientists in making informed decisions on macroinvertebrate conservation. However, CS is not developed nor implemented uniformly across the globe, and there are biases and challenges in the extent that it can contribute to global macroinvertebrate conservation. Here, a meta-analysis was performed using 107 Citizen Science Projects (CSPs) to identify underlying biases related to taxon representativity, country wealth, and demographic participation. Macroinvertebrate orders with the highest representativity were Lepidoptera and Hymenoptera, accounting for 53% of represented macroinvertebrate groups. The orders Scorpiones, Parasitiformes, and Spirobolida had proportionately the highest IUCN threat statuses, but significantly lower CSP representation, indicating that these orders require more public attention. Hymenoptera, Odonata, Coleoptera, Hemiptera, Diptera and Clitellata had the highest levels of Data Deficient species, suggesting that the primary objective of CSPs targeted at these orders should be collecting distribution and abundance data to improve Red List assessments. Global distribution of CSPs was uneven and the number of CSPs per country was positively correlated with national Gross Domestic Product (GDP) and GDP per capita, suggesting that countries with relatively low GDP face challenges to successfully establish and maintain CSPs. Establishing new CSPs can assist macroinvertebrate conservation in these countries, where biodiversity levels are often high. To accommodate these biases, CSP development should adopt a bottom-up approach, in which CSPs are designed to address data gaps, and to address local socio-economic limitations and cultural ideologies. Guidelines for such development are presented here, with emphasis on addressing societal variations and inter-disciplinary communication gaps to ensure equitable opportunities for CSP participation.
Experimental characterisation of the local mechanical behaviour of cellulose fibres: an in-situ micro-profilometry approach
Authors: Maraghechi S. , Bosco E. , Suiker A. S. J. , Hoefnagels J. P. M. 
Published: March 2023

AbstractThe accurate mechanical characterisation of fibres of micrometric length is a challenging task, especially in the case of organically-formed fibres that naturally exhibit considerable irregularities along the longitudinal fibre direction. The present paper proposes a novel experimental methodology for the evaluation of the local mechanical behaviour of organically-formed (aged and unaged) and regenerated cellulose fibres, which is based on in-situ micro-tensile testing combined with optical profilometry. In order to accurately determine the cross-sectional area profile of a cellulose fibre specimen, optical profilometry is performed both at the top and bottom surfaces of the fibre. The evolution of the local stress at specific fibre locations is next determined from the force value recorded during the tensile test and the local cross-sectional area. An accurate measurement of the corresponding local strain is obtained by using Global Digital Height Correlation (GDHC), thus resulting in multiple, local stress–strain curves per fibre, from which local tensile strengths, elastic moduli, and strains at fracture can be deduced. Since the variations in the geometrical and material properties within an individual fibre are comparable to those observed across fibres, the proposed methodology is able to attain statistically representative measurement data from just one, or a small number of fibre samples. This makes the experimental methodology very suitable for the mechanical analysis of fibres taken from valuable and historical objects, for which typically a limited number of samples is available. It is further demonstrated that the accuracy of the measurement data obtained by the present, local measuring technique may be significantly higher than for a common, global measuring technique, since possible errors induced by fibre slip at the grip surfaces are avoided.
Inoculation of phosphate-solubilizing bacteria improves soil phosphorus mobilization and maize productivity
Authors: Beltran-Medina Isidro , Romero-Perdomo Felipe , Molano-Chavez Lady , Gutiérrez Angelica Y. , Silva Antonio M. M. , Estrada-Bonilla German 
Published: March 2023

AbstractPhosphate-solubilizing bacteria represent a bioalternative in making soil-immobilized phosphorus (P) available to plants, and consequently improve agriculture sustainability and reduce nutrient pollution. In this study, we examined whether Rhizobium sp. B02 inoculation can affect the soil P fractions. Moreover, we investigated how inoculation influences the growth, physiological traits, and productivity of the maize crop. Field tests were carried out to evaluate the combined application of strain B02 and reduced doses of P fertilizer. Soil P fractionation was performed after crop harvesting, assessing the P dynamics. To study the plant response, samplings were carried out in three phenological stages—the vegetative stage of the 7 fully emerged leaves with leaf collars (V7), the vegetative stage of the tassel (VT), and the reproductive stage of physiological maturity (R6). Using 50% of P fertilizer recommended, the strain inoculation increased the labile inorganic P fraction by 14% compared to the control treatment at the same dose, indicating that it favored the Pi mobility. Under these same conditions in the V7 and VT phenological stages, the inoculation significantly improved shoot length (28 and 3%) and shoot dry weight (9.8 and 12%). B02 inoculation increased grain yield by 696 kg ha−1 using 50% of the recommended rate of P fertilizer, phenocopying the complete P fertilization treatment without inoculation. Therefore, Rhizobium sp. B02 inoculation replaced 50% of P fertilizer in maize and increased the soil P availability.
Towards an institutional “landscape” view of modern money creation mechanisms and some reflections on their ecological significance
Authors: Hook Andrew 
Published: March 2023

AbstractIn recent years, a number of different strands within heterodox economic thinking have successfully provided more empirically robust and sociologically informed analyses of how money gets created. However, there is a tendency within these analyses to discuss the different money creation theories and institutional practices in isolation, inhibiting a broader audience from grasping the whole institutional picture. By integrating contemporary heterodox theories and the latest empirical evidence, this article therefore attempts to develop a “landscape” view of modern money creation that visualizes and explains the different ways that modern money is created. It suggests that, while it is ultimately only commercial banks that can “create” new bank deposits in customers’ accounts, this may be initiated by one of three institutional mechanisms: by customers “borrowing new money into existence” when commercial banks make loans; by central banks creating new money when they purchase assets such as government bonds from investors; and by the government “spending new money into existence”. The article also reflects on how a clearer institutional understanding of these processes may be helpful in improving our overall capacity to think about how money creation may better serve current urgent social and environmental needs, especially in the post-COVID-19 context.
A Study on the Impact of Silicon and Manganese on Peritectic Behavior in Low Alloy Steels Assisted by Mold Thermal Mapping Technology and Shell Growth Measurements
Authors: Balogun Damilola , Roman Muhammad , Gerald Rex E. , Bartlett Laura , Huang Jie , O’Malley Ronald 
Published: March 2023

AbstractNon-uniform shell growth commonly caused by the peritectic transformation in low carbon and low alloy steels has been directly correlated with mold thermal maps using a mold immersion test into a molten steel alloy. Mold thermal maps were obtained by performing real-time temperature measurements with optical fibers embedded 1 mm from the mold working surface. Shell growth measurements were obtained by 3D optical scanning of the recovered steel shell following immersion testing. The effects of silicon and manganese on the shell growth and mold temperature maps have been examined in relation to the peritectic transformation for varying carbon contents. Results of thermodynamic and kinetic simulations using ThermoCalc and its kinetic module—DICTRA predicted that silicon expands the carbon content range to values between (0.12 pct C to 0.21 pct C) where peritectic behavior occurs and that manganese shrinks the carbon content range and shifts the range to lower carbon contents (0.06 pct C to 0.12 pct C). The results of these simulations were used to guide the selection of chemistries examined in the dip test experiments with the aim of validating the software predictions. Dip tests were performed at similar steel making temperatures that were used for the software simulations between 1600 °C and 1650 °C. Both software results and experimental observation showed relatively good agreement for the compositions examined.
Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India: A Multicenter Feasibility Randomized Controlled Trial
Authors: Chattopadhyay Kaushik , Mishra Pallavi , Singh Kavita , Singh Kalpana , Harris Tess , Hamer Mark , Greenfield Sheila Margaret , Manjunath Nandi Krishnamurthy , Nair Rukamani , Mukherjee Somnath , Tandon Nikhil , Lewis Sarah Anne , Kinra Sanjay , Prabhakaran Dorairaj ,   YOGA-DP Study Team
Published: March 2023

Abstract
Introduction
Many Indians are at high risk of type 2 diabetes mellitus (T2DM). The blood glucose level can be improved through a healthy lifestyle (such as physical activity and a healthy diet). Yoga can help in T2DM prevention, being a culturally appropriate approach to improving lifestyle. We developed the Yoga Programme for T2DM Prevention (YOGA-DP), a 24-week structured lifestyle education and exercise (Yoga) program that included 27 group Yoga sessions and self-practice of Yoga at home. In this study, the feasibility of undertaking a definitive randomized controlled trial (RCT) was explored that will evaluate the intervention’s effectiveness among high-risk individuals in India.

Methods
A multicenter, two-arm, parallel-group, feasibility RCT was conducted in India. The outcome assessors and data analysts were blinded. Adults with a fasting blood glucose level of 100–125 mg/dL (i.e., at high risk of T2DM) were eligible. Participants were randomized centrally using a computer-generated randomization schedule. In the intervention group, participants received YOGA-DP. In the control group, participants received enhanced standard care.

Results
In this feasibility trial, the recruitment of participants took 4 months (from May to September 2019). We screened 711 people and assessed 160 for eligibility. Sixty-five participants (33 in the intervention group and 32 in the control group) were randomized, and 57 (88%) participants were followed up for 6 months (32 in the intervention group and 25 in the control group). In the intervention group, the group Yoga sessions were continuously attended by 32 (97%) participants (median (interquartile range, IQR) number of sessions attended = 27 (3)). In the intervention group, Yoga was self-practiced at home by 30 (91%) participants (median (IQR) number of days per week and minutes per day self-practiced = 2 (2) and 35 (15), respectively). In the control group, one (3%) participant attended external Yoga sessions (on Pranayama) for 1 week during the feasibility trial period. There was no serious adverse event.

Conclusions
The participant recruitment and follow-up and adherence to the intervention were promising in this feasibility study. In the control group, the potential contamination was low. Therefore, it should be feasible to undertake a definitive RCT in the future that will evaluate YOGA-DP’s effectiveness among high-risk people in India.

Feasibility Trial Registration
Clinical Trials Registry—India (CTRI) CTRI/2019/05/018893; registered on May 1, 2019.