bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotions as emergent properties
Authors: Walsh Elena 
Published: July 2023

In recent decades, affective scientists have begun using concepts and tools from dynamical systems theory (DST) to characterise emotional processes. This article considers how the concept of emergence might be used to develop this approach. Emotions are explicated as ‘emergent products’ that diachronically constrain the operations of their parts in virtue of feedback loops (a classical feature of nonlinear dynamical systems). The explication is shown to be broadly consistent with what is sometimes called ‘pattern’ emergence. Casting emotions as emergent patterns is shown to shed light on a major conceptual and empirical challenge emotion theorists have faced over the past century: identifying and measuring the presence of emotional episodes (Lindquist et al., 2012; Hollenstein & Lanteigne, 2014), dubbed here the ‘boundary problem’ (following Colombetti, 2014). In particular, the explication suggests seeing the emotional ‘signatures’ thought to accompany emotional episodes as fragile and context-bound: likely to hold under a relevant class of interventions (Woodward, 2005), but not without exception beyond that class. This in turn may suggest a need to significantly revise the statistical methods currently used to measure the presence of emotional ‘signatures’. The casting of emotions as emergent patterns also functions as a further case study supporting the value of ‘pattern emergence’ (Winning & Bechtel, 2019) as a powerful vehicle for characterising the objects of investigation — compound and context-sensitive — ubiquitous in the biological sciences.
Case series: Heinz body formation in 13 multimorbid dogs following metamizole administration
Authors: Geisen Vera , Hartmann Katrin , Dörfelt René 
Published: July 2023

BackgroundHeinz Body (HB) anemia is a result of oxidative damage and is an uncommon condition in dogs relative to cats. In this retrospective case series, clinical features, laboratory values, concurrent diseases, and outcomes of 13 multimorbid dogs that developed HBs after receiving metamizole are reported.Case descriptionOf the 13 dogs in this case series that developed HBs, 10 were older and multimorbid, but the only feature that all the dogs had in common was receiving metamizole. HBs were detected in 7 out of 13 dogs within a few days (3–10 days) after starting metamizole treatment. The metamizole dose was 38–159 mg/kg/day. The highest percentage of HBs detected was 28–95% (mean, 46%). There was no correlation between the percentage of HBs and the daily dose of metamizole. All but 1 dog had mild-to-severe anemia at the time of the highest HB appearance. The number of HBs did not correlate with the hematocrit at that time. In 8/12 dogs, no stress leukogram was present. Approximately half of the dogs with HBs also had evidence of gastrointestinal hemorrhage, which could have masked additional oxidative damage.ConclusionIn multimorbid dogs that develop regenerative anemia after receiving metamizole, hemolysis due to HB development caused by oxidative damage should be considered as an important differential diagnosis.
RANCANG BANGUN MULTIMEDIA INTERAKTIF MATERI KERAJAAN ISLAM DI INDONESIA KELAS IV SEKOLAH DASAR
Authors: Sofydianty Angelica , Tin Rustini  , Muh Husen Arifin  
Published: July 2023

Dilatarbelakangi oleh perkembangan teknogi abad 21 yang kian pesat sehingga mampu dimanfaatkan menjadi multimedia interaktif yang menunjang pembelajaran bermakna untuk peserta didik. Kurangnya variasi metode pembelajaran yang diterapkan oleh pendidik serta kondisi peserta didik yang kurang memahami materi. Peserta didik yang terbiasa menggunakan media pembelajaran berbasis teknologi digital maka peneliti bertujuan melakukan penelitian untuk mengetahui pengembangan multimedia interkatif materi kerjaan islam di Indonesia kelas IV sekolah dasar. Rancangan multimedia interaktif ini diawali dengan pembuatan GBPM, menyusun modul ajar, menentukan aplikasi yang digunakan, pemilihan format, hingga pembuatan multimedia interaktif. Penelitian ini menggunakan model penelitian Design and Development (D&D), dengan prosedur penelitian Analyze, Design, Development, Implementation, and Evaluation (ADDIE). Validasi multimedia interaktif ini dilakukan oleh ahli materi, ahli media, dan ahli bahasa.Intrumen yang digunakan yaitu wawancara, judgement/expert review dan angket. Hasil Penelitian media ini menunjukan kelayakan 95% dari ahli materi, 97,5% dariu ahli media, dan 86% dari ahli bahasa. Masukan dan saran dari validator menjadi acuan dalam memperbaiki produk untuk selanjutnya diujicobakan kepadapengguna dengan perolehan hasil kelayakan 92,5% dari pendidik dan perolehan hasil kelayakan 92,25% peserta didik kelas 4 SDN 231 Sukaasih. Berdasarkan hal tersebut, maka multimedia interkatif materi kerjaan islam di Indonesia sangat layak digunakan dalam pembelajaran.
PERBEDAAN TEKNIK KOMPRES AIR HANGAT DAN MASSEGE TERHADAP INTENSITAS NYERI PERSALINAN PADA FASE AKTIF DI PUSKESMAS BOTTENG KECAMATAN SIMBORO KABUPATEN MAMUJU TAHUN 2022
Authors: Parwati Dewi , Uniatri Thalib Kiki 
Published: July 2023

Latar Belakang Rasa nyeri pada persalinan dalam hal ini adalah nyeri kontraksi uterus yang dapat mengakibatkan peningkatan aktifitas sistem saraf simpatis, perubahan tekanan darah, denyut jantung, pernafasan dan apabila tidaksegera diatasi maka akan meningkatkanya rasa khawatir, tegang, takut dan stress sehingga dibutuhan metode non farmakologi seperti teknik kompres air haangat dan Massase.Tujuan penelitian ini adalah Untuk mengetahui perbedaan teknik kompres air hangat dan massege terhadap intensitas nyeri persalinan pada kala1 fase aktif di Puskesmas Botteng, Kecamatan Simboro Kabupaten Mamuju Tahun 2022.Jenis penelitian yang digunakan adalah penelitian eksperimental dengan metode penelitian yang digunakan adalah Eksperimen yaitu Quasi Eksperimental, dengan pendekatan Post Test Only dengan tindakan dilakukan teknik kompres air hangat dan dilakukan massase.Hasil penelitian diperoleh dari uji T Independen, didapatkan nilai t hitung sebesar 1,892 dengan p-value 0,323 karena p-value 0,323 > α (0,05), maka dapat disimpulkan bahwa tidak ada perbedaan yang bermakna antara teknik kompres hangat dan teknik massase terhadap pengurangan nyeri persalinan kala I fase aktif di Puskesmas Botteng, Kecamatan Simboro Kabupaten Mamuju Tahun 2022.Diharapkan agar bidan/perawat dapat membantu memenuhi kebutuhan ibu akan rasa nyaman dalam pengontrolan nyeri secara nonfarmakologis saat memberikan pertolongan persalinan dengan menerapkan teknik kompres hangat dan teknik massase.
1831 TARİHLİ GİRİT-RESMO’YA AİT BİR MÜRUR DEFTERİ
Authors: ADIYEKE Nuri 
Published: July 2023

Farklı dönemlerde ve coğrafyada olduğu gibi Osmanlı İmparatorluğu’nda da yolculuklar sıkı kurallara bağlanmış, yolculuk yapmak isteyenlere de özel bir izin belgesi, müruriye verilerek kontrollü bir yolculuk yapılmasına izin verilmiştir. Osmanlı İmparatorluğu’nda özellikle 19. yüzyılın ikinci çeyreğinde yoğunlaşan bu uygulama imparatorluğun sonuna kadar devam etmiştir.
1831 yılına ait Girit-Resmo’ya ait üç yüzün üzerinde mürur kaydının bulunduğu bir mürur defteri, adı geçen yılın yaz aylarında Resmo’dan yapılan seyahatler hakkında detaylı bilgiler vermektedir. Defterde yolcunun kimlik bilgileri, vücut özellikleri, nereye gidecekleri ve kendilerine kefil olanlar hakkında ayrıntılı bilgiler verilmektedir. Bu kayıtlardan yolculuk yönleri, insanların fiziki tanımlamaları, meslekleri gibi konularda bilgiler sunmaktadır.
Defter kayıtları iki buçuk aylık bir süreyi kapsamaktadır. Az sayıda yolculuk yapan kadın olmakla birlikte yolcuların çok büyük bir kısmının erkek olduğu anlaşılmaktadır. Yolculuk güzergahı büyük oranda ada içinde idi. Bunun yanısıra Mısır, İzmir gibi merkezlerin dışında çevre adalara yolculuk yapanlar da bulunmaktadır.
تقدير تركيز أيونات الفلوريد في بعض عينات مياه الشرب الجوفية لبعض المناطق في ليبيا ) المنطقة الشمالية الشرقية (
Authors: إدريس حمد محمد 
Published: July 2023

تم جمع 18 عينة من مياه الشرب من مصادر جوفية تقع في المنطقة الشمالية الشرقية من لبيبا وذلك خلال عام 2007 ، تم تحليل أيون الفلوريد في عينات المياه وذلك لأول مره في منطقة الدراسة ، وقد دلت نتائج التحليل على أن تركيز ايونات الفلوريد تراوحت في المدى ) 0.10 – 1.4 mg\L ( . تم مقارنة النتائج المتحصل عليها مع المعايير الدولية لنسب ايونات الفلوريد وكذلك مع معدلات ايون الفلوريد في بعض مصادر المياه العربية و العالمية . و أتضح من نتائج التحاليل إن تركيز ايونات الفلوريد تقع ضمن المدى المسموح به في مياه الشرب لمعظم المناطق المدروسة .
MỘT SỐ VẤN ĐỀ LIÊN QUAN ĐẾN THUỐC TRONG KÊ ĐƠN ĐIỀU TRỊ NGOẠI TRÚ TRÊN BỆNH NHÂN CAO TUỔI TẠI TRUNG TÂM Y TẾ TRÀ CÚ, TỈNH TRÀ VINH NĂM 2022
Authors: Bùi Minh Thiện , Dương Xuân Chữ 
Published: July 2023

Đặt vấn đề: Việc sử dụng thuốc không hợp lý ở người cao tuổi dễ gây nên các vấn đề liên quan đến sử dụng thuốc (DRPs). Các vấn đề liên quan đến sử dụng thuốc phổ biến ở người cao tuổi bao gồm: sự không hiệu quả của thuốc, chỉ định chưa phù hợp, dùng quá liều, dùng chưa đủ liều thuốc và tương tác thuốc. Mục tiêu nghiên cứu: Xác định tỷ lệ xuất hiện một số vấn đề liên quan đến thuốc trong kê đơn điều trị ngoại trú trên bệnh nhân cao tuổi. Đối tượng và phương pháp nghiên cứu: Nghiên cứu được thực hiện trên đơn thuốc điều trị ngoại trú của bệnh nhân người cao tuổi có bảo hiểm y tế và bác sĩ điều trị tại Trung tâm Y tế Trà Cú, tỉnh Trà Vinh trong năm 2022. Nghiên cứu mô tả cắt ngang, phương pháp thu thập số liệu hồi cứu. Kết quả: Trong 450 đơn thuốc ngoại trú của bệnh nhân cao tuổi được khảo sát. Tỷ lệ xuất hiện ít nhất một vấn đề liên quan đến sử dụng thuốc là 249 đơn thuốc chiếm 55,3%. Trong đó, nhóm DRP về chỉ định dùng thuốc chưa hợp lý là 6,9%, nhóm DRP về liều dùng chưa hợp lý 21,5%, nhóm số lần dùng thuốc chưa hợp lý 38,7%, nhóm DRP về thời điểm dùng thuốc trong ngày chưa hợp lý 28,9%, nhóm DRP về thời điểm dùng thuốc so với bữa ăn là 12% và tương tác nghiêm trọng của thuốc trong đơn là 6,4%. Kết luận: Tỷ lệ DRP liên quan đến kê đơn cho người cao tuổi là khá cao. Lựa chọn số lần dùng thuốc chưa phù hợp, thời điểm dùng thuốc chưa chưa hợp lý và lựa chọn liều dùng chưa phù hợp là DRP phổ biến nhất trong nghiên cứu của chúng tôi.
Investigating the relationship between inbreeding and life expectancy in dogs: mongrels live longer than pure breeds
Authors: Mata Fernando , Mata Andreia 
Published: July 2023

This study aimed to investigate the establishment of relationship between inbreeding and life expectancy in dogs. A dataset of N = 30,563 dogs sourced from the VetCompass™ Program, UK was made available by the Royal Veterinary College, University of London, containing information about breed and longevity and was subject to survival analysis. A Cox regression proportional hazards model was used to differentiate survivability in three groups of dogs (mongrel, cross-bred and pure breed). The model was found highly significant (p < 0.001) and we found that mongrel dog had the highest life expectancy, followed by cross-bred dogs with only one purebred ancestor and purebred dogs had the lowest life expectancy. A second Cox regression was also found highly significant (p < 0.001) differentiating the lifespan of different dog breed and correlating positively the hazard ratio and the Genetic Illness Severity Index for Dogs (GISID). The results show that survivability is higher in mongrel dogs followed by cross-bred with one of the ancestor only as a pure breed, and pure breed dog have the highest morbidity level. Higher morbidity is associated with higher GISID scores, and therefore, higher inbreeding coefficients. These findings have important implications for dog breeders, owners, and animal welfare organizations seeking to promote healthier, longer-lived dogs.
Molecular Characterization of Salmonella Species Isolated from Animal Sources in Southern-Taraba State, North-East Nigeria
Authors: Abhadionmhen Abel Onolunosen , Anyiam Vivian Ifeoma , Imarenezor Edobor Peter Kenneth , Brown Samuel Tamuno Cockeye 
Published: July 2023

Aims: The purpose of this research was to detect the Salmonella invA gene from chicken’s droppings in Southern Taraba, North East Nigeria. The invasive “invA” gene facilitates the invasion of epithelial cells by Salmonella isolates.
Study Design: This study is experimental research involving ninety-eight (98) Salmonella isolates from chicken droppings in poultry farms and domestic chicken coops.
Place and Duration of Study: This research was carried out in Wukari, Donga, Ibi and Takum towns in Southern Taraba, North East Nigeria between November 2021 and May 2023. A total of 400 (Donga,100; Wukari, 100; Ibi, 100 and Takum, 100) Chicken droppings were collected from 40
(Donga, 10; Wukari, 10; Ibi, 10 and Takum, 10) small-scale poultry farms, and 100 (Donga, 25; Wukari, 25; Ibi, 25 and Takum, 25) Chicken droppings were sampled from 20 (Donga, 5; Wukari, 5; Ibi, 5 and Takum 5) domestic chicken coops and analyzed.
Methodology: Using standard microbiological techniques, Salmonella Shigella Agar (SSA) was used to confirm and validate 98 (Wukari; 36, Donga; 19, Ibi; 27, and Takum; 16) Salmonella isolates from stock culture. Isolates were further subjected to biochemical analysis. Boiling technique was used to extract the DNA of the 98 isolates. Salmonella invA gene amplification process was done using Polymerase Chain Reaction (PCR). Electrophoresis was done using agarose gel, and DNA band patterns were visualized with the aid of ultraviolent light (UV) showing different patterns and interpreted with the 100 bp DNA ladder.
Results: The results of this study indicate that the invA gene was detected in 80.6% (Wukari; 86.1%, Donga; 68.5%, Ibi;85.2%, and Takum; 75%) of the 98 Salmonella isolates with an amplicon size of 284bp. This finding implies that 19 isolates which did not show the targeted band are not invasive, and even if they are, other invasive genes may be liable.
Conclusion: The detection of the invasive invA invasive gene from Salmonella isolates from the fecal droppings of apparently healthy chickens from poultry farms and domestic chicken coops is really of great concern to public health. Unless a proper hygienic protocol and biosecurity measures are strictly adhered to where applicable in food processing chain, Salmonella isolates harboring the invA traits could be opportunistically invasive among immunocompromised individuals and children.
Effects of Cucumis sativus Extract on the Histomorphology of the Ovaries and Hormonal Profile of Adult Female Wistar Rats
Authors: Okafor E. C. , Ndukwe G. U. , Akpuaka F. C. , Okechukwu H. K. 
Published: July 2023

Background: Drugs of plant origin have served through the ages as the mainstay in treating diseases and preserving human health. The cucumber is one of the plants that have nutritional values.
Aim: This study was conducted to investigate the effect of Cucumis sativus extract on the ovaries and sex hormones of adult female Wistar rats.
Study Design and Methodology: Sixteen Wistar rats weighing 180-200g were divided into four groups (A-D) of four animals each. Group A (control) received only distilled water and feed, Group B received 250 mg/kg body weight of cucumber fruit extract, Group C received 400 mg/kg body weight of cucumber fruit extract, and Group D received 1200 mg/kg body weight of cucumber fruit extract. All the treatments were given orally daily for twenty-one days. The animals were sacrificed by cervical dislocation and dissected; the ovaries were harvested and fixed in 10% formal saline for histological studies, while blood was collected for hormonal analysis.
Results: There was a significant increase (p<0.05) in the FSH level of group B only when compared to the control groups while a non-significant decrease in the estradiol level in all the treatment groups compared to the control. Histopathological studies show little distortion in the histomorphology of the ovaries in groups C and D.
Conclusion: Cucumis sativus extract, when consumed in large amount, has deleterious effects on the female reproductive system.
Controllable construction of “degressive gradient” transition layer on carbon fibers surface to enhance interfacial properties of carbon fiber/epoxy composites by layer upon layer assembly of carbon nano tubes
Authors: Zhu Junjie , Song Guojun , Wang Chaohang , Li Li , Zheng Hao , Zhang Wenjian , Li Bowen , Ma Lichun 
Published: July 2023

AbstractCarbon fiber (CF) reinforced epoxy (EP) matrix composite was widely used in industries, however, the mismatch of modulus between CFs and resin would lead to easy damage at the composite interface. In addition, complex modification methods limited the application of CF composite. To address these problems, a simple and efficient physical coating method was used to introduce a degressive gradient modulus layer on the CF surface. The “stepped modulus” structure could effectively disperse stress, improve the mechanical interlocking and wettability, and realize the modulus matching between fiber and resin, thus significantly improving the interface properties of the composites. The interfacial properties of Cn‐CNT‐CF/EP (n was the number of coatings) were gradually improved with the controllable gradient modulus layer established. The interlaminar shear strength (ILSS) and transverse fiber bundle (TFB) strength of C4‐CNTs‐CF/EP were increased by 65.7% and 85.6%, respectively. Due to the presence of a “degressive gradient” modulus layer, the improved mechanical properties of the Cn‐CNT‐CF/EP were comparable to or even more significant than other complicated approaches found in the literature. This simple and effective composite interface construction technique laid the theoretical and practical foundation for the preparation of high‐performance CF composite.
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m6A RNA methylation in ocular melanoma
Authors: Zhuang Ai , Gu Xiang , Ge Tongxin , Wang Shaoyun , Ge Shengfang , Chai Peiwei , Jia Renbing , Fan Xianqun 
Published: July 2023

AbstractBackgroundDiversified histone deacetylation inhibitors (HDACis) have demonstrated encouraging outcomes in multiple malignancies. N6‐methyladenine (m6A) is the most prevalent messenger RNA modification that plays an essential role in the regulation of tumorigenesis. Howbeit, an in‐depth understanding of the crosstalk between histone acetylation and m6A RNA modifications remains enigmatic. This study aimed to explore the role of histone acetylation and m6A modifications in the regulation of tumorigenesis of ocular melanoma.MethodsHistone modification inhibitor screening was used to explore the effects of HDACis on ocular melanoma cells. Dot blot assay was used to detect the global m6A RNA modification level. Multi‐omics assays, including RNA‐sequencing, cleavage under targets and tagmentation, single‐cell sequencing, methylated RNA immunoprecipitation‐sequencing (meRIP‐seq), and m6A individual nucleotide resolution cross‐linking and immunoprecipitation‐sequencing (miCLIP‐seq), were performed to reveal the mechanisms of HDACis on methyltransferase‐like 14 (METTL14) and FAT tumor suppressor homolog 4 (FAT4) in ocular melanoma. Quantitative real‐time polymerase chain reaction (qPCR), western blotting, and immunofluorescent staining were applied to detect the expression of METTL14 and FAT4 in ocular melanoma cells and tissues. Cell models and orthotopic xenograft models were established to determine the roles of METTL14 and FAT4 in the growth of ocular melanoma. RNA‐binding protein immunoprecipitation‐qPCR, meRIP‐seq, miCLIP‐seq, and RNA stability assay were adopted to investigate the mechanism by which m6A levels of FAT4 were affected.ResultsFirst, we found that ocular melanoma cells presented vulnerability towards HDACis. HDACis triggered the elevation of m6A RNA modification in ocular melanoma. Further studies revealed that METTL14 served as a downstream candidate for HDACis. METTL14 was silenced by the hypo‐histone acetylation status, whereas HDACi restored the normal histone acetylation level of METTL14, thereby inducing its expression. Subsequently, METTL14 served as a tumor suppressor by promoting the expression of FAT4, a tumor suppressor, in a m6A‐YTH N6‐methyladenosine RNA‐binding protein 1‐dependent manner. Taken together, we found that HDACi restored the histone acetylation level of METTL14 and subsequently elicited METTL14‐mediated m6A modification in tumorigenesis.ConclusionsThese results demonstrate that HDACis exert anti‐cancer effects by orchestrating m6A modification, which unveiling a “histone‐RNA crosstalk” of the HDAC/METTL14/FAT4 epigenetic cascade in ocular melanoma.
The use of prescription drugs and health care services during the 6-month post-COVID-19 period
Authors: Mooses Kerli , Vesilind Kaarel , Oja Marek , Tamm Sirli , Haug Markus , Kalda Ruth , Suija Kadri , Tisler Anna , Meister Tatjana , Malk Maria , Uusküla Anneli , Kolde Raivo 
Published: July 2023

AbstractCOVID-19 and other acute respiratory viruses can have a long-term impact on health. We aimed to assess the common features and differences in the post-acute phase of COVID-19 compared with other non-chronic respiratory infections (RESP) using population-based electronic health data. We applied the self-controlled case series method where prescription drugs and health care utilisation were used as indicators of health outcomes during the six-month-long post-acute period. The incidence rate ratios of COVID-19 and RESP groups were compared. The analysis included 146 314 individuals. Out of 5452 drugs analysed, 14 had increased administration after COVID-19 with drugs for cardiovascular diseases (trimetazidine, metoprolol, rosuvastatin) and psychotropic drugs (alprazolam, zolpidem, melatonin) being most prevalent. The health impact of COVID-19 was more apparent among females and individuals with non-severe COVID-19. The increased risk of exacerbating pre-existing conditions was observed for the COVID-19 group. COVID-19 vaccination did not have effect on drug prescriptions but lowered the health care utilisation during post-acute period. Compared with RESP, COVID-19 increased the use of outpatient services during the post-infection period. The long-term negative impact of COVID-19 on life quality must be acknowledged, and supportive health care and public health services provided.
Digital workplace health promotion: a pilot study during the SARS-CoV-2 pandemic in Germany
Authors: Nöhammer Elisabeth , Fischmann Wolfgang 
Published: July 2023

PurposePreventing diseases and promoting health is most effective in large settings like the workplace. Digital workplace health promotion (DWHP) became more popular during the SARS-CoV-2 pandemic. While e-health appliances have received research interest, little is known regarding the target populations' perspective on and potentials of the DWPH.Design/methodology/approachAn online pilot study was done in Germany in June 2021. The study is representative regarding age, gender and education. The user perspective on DWHP was investigated using 12 quantitative and 2 qualitative items.FindingsThe majority of the 690 participants perceives DWHP as valid long-term addition to regular workplace health promotion. Nearly 55.7% use DWHP when available, but most (65.4%) do not use these offers more than regular ones. Spontaneous participation is relevant for about 55%. Problems occur due to technical equipment (29.4%) and premises (36.3%). Open remarks highlight specifics to be observed in offer design, for example, data security issues.Research limitations/implicationsTo conclude, DWHP has a high potential to improve health at the workplace initiatives regarding participation rates, outcomes and costs. Challenges can be overcome by ensuring data protection and skills, which can be transferred to other life domains, improving population health. The potentials of DWHP for population health via spillover effects, employee well-being and employer branding have not yet been reached.Originality/valueThe aim of this study is giving a first overview of employee views on and use of DWHP.