bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Simulation of Ileal Pouch–Anal Anastomosis in Patients With Ulcerative Colitis Using a 3-Dimensional Printed Model
Authors: Yokose Shota , Murono Koji , Nozawa Hiroaki , Sasaki Kazuhito , Emoto Shigenobu , Matsuzaki Hiroyuki , Yokoyama Yuichiro , Abe Shinya , Nagai Yuzo , Yoshioka Yuichiro , Shinagawa Takahide , Sonoda Hirofumi , Murai Shin , Komatsu Koichi , Ishihara Soichiro 
Published: January 2023

Abstract

Background
During restorative proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis–associated colorectal cancer or dysplasia, ileal pouch–anal handsewn anastomosis (IAA) is preferred to avoid the risk of cancer development in the remaining rectal mucosa. However, there is a risk of the ileal pouch not reaching the anus with this procedure. Here, we created deformable 3-dimensional (3D) models for simulation.

Method
Six patients who underwent IAA without vessel ligation and 5 patients who underwent ileal pouch–anal canal double-stapled anastomosis (IACA) because the ileal pouch did not reach the anus were studied. A 3D printer was used to create deformable 3D models from the data obtained from computed tomography scans. The positional relationship among the mesenteric arteries, pubis, and coccyx were evaluated.

Result
The distance between the superior mesenteric artery root and the tip of the ileal artery was longer in the IAA group than that in the IACA group (IAA vs IACA: 26.2 ± 2.1 cm vs 20.9 ± 1.6cm). The distance from the tip of the ileal artery to the coccyx (IAA vs IACA: 6.7 ± 1.7 cm vs 12.1 ± 2.1 cm) and the distance from the tip of the ileal artery to the lower edge of the pubis (IAA vs IACA; 8.1 ± 1.3 cm vs 12.7 ± 2.4 cm) were longer in the IACA group than those in the IAA group.

Conclusions
We established a method for creating 3D deformable models of patients with ileal pouch–anal anastomosis. These 3D models may be useful for preoperative simulation.
Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair
Authors: Garcia-Hernandez Vicky , Raya-Sandino Arturo , Azcutia Veronica , Miranda Jael , Kelm Matthias , Flemming Sven , Birkl Dorothee , Quiros Miguel , Brazil Jennifer C , Parkos Charles A , Nusrat Asma 
Published: January 2023

Abstract

Background
Incidences of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are escalating worldwide and can be considered a global public health problem. Given that the gold standard approach to IBD therapeutics focuses on reducing the severity of symptoms, there is an urgent unmet need to develop alternative therapies that halt not only inflammatory processes but also promote mucosal repair. Previous studies have identified increased stem cell factor (SCF) expression in inflamed intestinal mucosal tissues. However, the role that SCF plays in mediating intestinal inflammation and repair has not been explored.

Methods
Changes in the expression of SCF were evaluated in the colonic tissue of healthy mice and during dextran sodium sulfate (DSS)-induced colitis. Furthermore, mucosal wound healing and colitis severity were analyzed in mice subjected to either mechanical biopsy or DSS treatment, respectively, following intestinal epithelial cell–specific deletion of SCF or anti-SCF antibody administration.

Results
We report robust expression of SCF by intestinal epithelial cells during intestinal homeostasis with a switch to immune cell-produced SCF during colitis. Data from mice with intestinal epithelial cell–specific deletion of SCF highlight the importance of immune cell–produced SCF in driving the pathogenesis of colitis. Importantly, antibody-mediated neutralization of total SCF or the specific SCF248 isoform decreased immune cell infiltration and enhanced mucosal wound repair following biopsy-induced colonic injury or DSS-induced colitis.

Conclusions
These data demonstrate that SCF functions as a pro-inflammatory mediator in mucosal tissues and that specific neutralization of SCF248 could be a viable therapeutic option to reduce intestinal inflammation and promote mucosal wound repair in individuals with IBD.
Increasing the uptake of multispecies models in fisheries management
Authors: Karp Melissa A , Link Jason S , Grezlik Max , Cadrin Steve , Fay Gavin , Lynch Patrick , Townsend Howard , Methot Richard D , Adams Grant D , Blackhart Kristan , Barceló Caren , Buchheister Andre , Cieri Matthew , Chagaris David , Christensen Villy , Craig J Kevin , Cummings Jonathan , Damiano Matthew D , Dickey-Collas Mark , Elvarsson Bjarki Þór , Gaichas Sarah , Haltuch Melissa A , Haugen Janne B , Howell Daniel , Kaplan Isaac C , Klajbor Willem , Large Scott I , Masi Michelle , McNamee Jason , Muffley Brandon , Murray Sarah , Plagányi Éva , Reid David , Rindorf Anna , Sagarese Skyler R , Schueller Amy M , Thorpe Robert , Thorson James T , Tomczak Maciej T , Trijoulet Vanessa , Voss Rudi 
Published: January 2023

AbstractMultispecies models have existed in a fisheries context since at least the 1970s, but despite much exploration, advancement, and consideration of multispecies models, there remain limited examples of their operational use in fishery management. Given that species and fleet interactions are inherently multispecies problems and the push towards ecosystem-based fisheries management, the lack of more regular operational use is both surprising and compelling. We identify impediments hampering the regular operational use of multispecies models and provide recommendations to address those impediments. These recommendations are: (1) engage stakeholders and managers early and often; (2) improve messaging and communication about the various uses of multispecies models; (3) move forward with multispecies management under current authorities while exploring more inclusive governance structures and flexible decision-making frameworks for handling tradeoffs; (4) evaluate when a multispecies modelling approach may be more appropriate; (5) tailor the multispecies model to a clearly defined purpose; (6) develop interdisciplinary solutions to promoting multispecies model applications; (7) make guidelines available for multispecies model review and application; and (8) ensure code and models are well documented and reproducible. These recommendations draw from a global assemblage of subject matter experts who participated in a workshop entitled “Multispecies Modeling Applications in Fisheries Management”.
Periodical Evidence for the Original Publication of Richardson’s New Dictionary of the English Language
Authors: Considine John 
Published: January 2023

Abstract
Charles Richardson’s New Dictionary of the English Language is a work of great importance for the history of lexicography, but the dates of its first serial publication from 1818 onwards among the 59 instalments of the Encyclopaedia Metropolitana appear never to have been ascertained. They are worked out here, together with the alphabetical ranges of many instalments, from announcements in contemporary periodicals such as the Athenaeum, the Morning Chronicle, and The Times, and are followed by extracts from the first reviews of the dictionary in the same periodicals.
Integration of Cutaneous Functional Units Principles in Burn Rehabilitation: A Diffusion of Innovations Assessment
Authors: Yelvington Miranda L , Parry Ingrid 
Published: January 2023

Abstract
Early recognition of contractures can lead to a more targeted therapy regimen, potentially preventing range of motion losses and improving function and quality of life. Cutaneous functional units (CFUs) allow therapists to explain motion limitations and formulate patient-specific treatment plans. Evidence-based research demonstrates the potential of using these principles to improve the current standard of care. Still, the consistent use of these principles has been slow to diffuse through burn care. Occupational and physical therapists were surveyed to determine the degree to which CFU principles are being integrated into clinical practice. Respondents (297) were occupational therapists (52%) and physical therapists (49%) working in burn units (81%) in North America (70.7%). Most respondents (78.4%) report familiarity with CFU principles. Of those familiar, most respondents reported their knowledge (66.7%) and ability to apply (65.7%) at an intermediate level or greater. A slight majority (59.3%) responded that the concepts influenced their practice, while 40.7% said the concepts did not influence their practice. Forty percent to sixty-nine percent of respondents correctly answered knowledge questions, but only 15% of respondents correctly completed CFUs identification questions. Respondents (77%) report barriers, including difficulty incorporating into practice, time constraints, and the need for more education. Results suggest that diffusion can be improved by developing tools to assist therapists in understanding and incorporating CFUs’ principles.
Aedes aegyptiandAedes albopictus(Diptera: Culicidae) Oviposition Activity and the Associated Socio-environmental Factors in the New Orleans Area
Authors: Thongsripong Panpim , Carter Brendan H , Ward Matthew J , Jameson Samuel B , Michaels Sarah R , Yukich Joshua O , Wesson Dawn M 
Published: January 2023

AbstractThe transmission of Aedes-borne viruses is on the rise globally. Their mosquito vectors, Aedes aegypti (Linnaeus, Diptera: Culicidae) and Ae. albopictus (Skuse, Diptera: Culicidae), are focally abundant in the Southern United States. Mosquito surveillance is an important component of a mosquito control program. However, there is a lack of long-term surveillance data and an incomplete understanding of the factors influencing vector populations in the Southern United States. Our surveillance program monitored Ae. aegypti and Ae. albopictus oviposition intensity in the New Orleans area using ovicups in a total of 75 sites from 2009 to 2016. We found both Aedes spp. throughout the study period and sites. The average number of Ae. aegypti and Ae. albopictus hatched from collected eggs per site per week was 34.1 (SD = 57.7) and 29.0 (SD = 46.5), respectively. Based on current literature, we formed multiple hypotheses on how environmental variables influence Aedes oviposition intensity, and constructed Generalized Linear Mixed Effect models with a negative binomial distribution and an autocorrelation structure to test these hypotheses. We found significant associations between housing unit density and Ae. aegypti and Ae. albopictus oviposition intensity, and between median household income and Ae. albopictus oviposition intensity. Temperature, relative humidity, and accumulated rainfall had either a lagged or an immediate significant association with oviposition. This study provides the first long-term record of Aedes spp. distribution in the New Orleans area, and sheds light on factors associated with their oviposition activity. This information is vital for the control of potential Aedes-borne virus transmission in this area.
A randomized comparison of group mindfulness and group cognitive behavioral therapy vs control for couples after prostate cancer with sexual dysfunction
Authors: Kemerer Bibiana M , Zdaniuk Bozena , Higano Celestia S , Bossio Jennifer A , Camara Bicalho Santos Raysa , Flannigan Ryan , Brotto Lori A 
Published: January 2023

AbstractBackgroundSexual dysfunction is the most common and most distressing consequence of prostate cancer (PCa) treatment and has been shown to directly affect the sexual function and quality of life of survivors’ partners. There are currently no established therapies to treat the emotional and psychological burden that sexual issues impose on the couple after PCa.AimOur study examined the impact of 2 therapies—cognitive behavioral therapy (CBT) and mindfulness therapy—on sexual, relational, and psychological outcomes of PCa survivor and partner couples.MethodsPCa survivors (n = 68) who self-reported current sexual problems after PCa treatments and their partners were randomized to 4 consecutive weeks of couples’ mindfulness therapy, couples’ CBT, or no treatment (control).OutcomesCouples’ sexual distress, survivors’ sexual satisfaction, and couples’ relationship satisfaction, quality of life, psychological symptoms (anxiety and depression), and trait mindfulness were measured at baseline, 6 weeks after treatment, and 6 months after treatment.ResultsSexual distress and sexual satisfaction were significantly improved 6 weeks after the CBT and mindfulness interventions as compared with the control group, but only sexual distress remained significantly improved at 6 months. Relationship satisfaction decreased and more so for partners than survivors. There were increases in domains of quality of life for survivors vs their partners 6 months after treatments and an overall increase in general quality of life for couples 6 weeks after mindfulness. There were no significant changes in psychological symptoms and trait mindfulness. Qualitative analysis showed that the mindfulness intervention led to greater personal impact on couple intimacy after the study had ended.Clinical ImplicationsCBT and mindfulness can be effective treatments for helping couples adapt to and cope with changes to their sexual function after PCa treatments and could help improve the most common concern for PCa survivors—that is, couples’ sexual intimacy—after cancer, if added to routine clinical care.Strengths and LimitationsWe used established standardized treatment manuals and highly sensitive statistical methodology and accounted for covariable factors and moderators of primary outcomes. Due to difficulty in recruitment, we had a smaller control group than treatment, reducing our power to detect between-group differences. Our sample was mostly White, heterosexual, and affluent, thereby limiting the generalizability.ConclusionThis is the first randomized clinical trial to test and demonstrate benefits among PCa survivors and partners’ sexual outcomes after CBT and mindfulness as compared with a nontreatment control group.
Relationship between arthritis of the second and third tarsometatarsal joints and incongruity of the first tarsometatarsal joint in patients with hallux valgus
Authors: Hosokawa Toshihiro , Ikoma Kazuya , Maki Masahiro , Kido Masamitsu , Hara Yusuke , Sotozono Yasutaka , Takahashi Kenji 
Published: January 2023

ABSTRACT

Objectives
Hallux valgus is associated with tarsometatarsal arthritis; its pathophysiology remains unknown. Therefore, we aimed to elucidate the relationship between arthritis of the second and third tarsometatarsal joints and incongruity of the first tarsometatarsal joint in the sagittal plane.

Methods
Forty-three patients (64 feet) with hallux valgus who underwent surgery at University Hospital Kyoto Prefectural University of Medicine were included and divided into two groups: control (without second and third tarsometatarsal joint degeneration) and osteoarthritis (with second and third tarsometatarsal joint degeneration). Intergroup comparisons of the incongruity of the first tarsometatarsal joint in the sagittal plane, age, body mass index, hallux valgus angle, first–second intermetatarsal angle, metatarsus adductus angle, Meary’s angle, and calcaneal pitch angle were performed.

Results
The proportion of patients with incongruity of the first tarsometatarsal joint was significantly higher in the osteoarthritis group than in the control group. Logistic regression analysis identified incongruity of the first tarsometatarsal joint and metatarsus adductus angle as significant related factors for arthritis of the second and third tarsometatarsal joints.

Conclusions
Incongruity of the first tarsometatarsal joint in the sagittal plane was involved in the development of arthritis of the second and third tarsometatarsal joints in patients with hallux valgus.
The effect of smoking on response to methotrexate in rheumatoid arthritis patients: A systematic review and meta-analysis
Authors: Nayebirad Sepehr , Javinani Ali , Javadi Minoo , Yousefi-Koma Hannaneh , Farahmand Kimia , Atef Yekta Reza , Tamartash Zahra , Mohammadzadegan Amir Mohammad , Salehi Samira , Kavosi Hoda 
Published: January 2023

ABSTRACTObjectivesIn the current study, we aimed to investigate the effect of smoking on inadequate response to methotrexate (MTX-IR) in rheumatoid arthritis (RA) patients.MethodsWe searched PubMed, Embase, and Web of Science until 6 June 2022. Observational or interventional studies investigating MTX-IR in RA patients based on smoking status were included. Two independent reviewers assessed the risk of bias and the certainty of the evidence using the Risk of Bias in Nonrandomized Studies–of Interventions and Grades of Recommendation, Assessment, Development, and Evaluation tools, respectively.ResultsWe included 23 studies in the systematic review and 13 in the meta-analysis. Of the 13 included studies, 6 had a moderate risk, 3 had a serious risk, and 4 had a critical risk of bias. The overall random-effect meta-analysis suggested that smokers were 58% more likely to be MTX-IR when compared with nonsmokers [odds ratio (OR) 1.58, 95% confidence interval 1.21–2.06; P = .001; I2 = 69.3%]. The common-effect meta-analysis of the adjusted ORs demonstrated an overall OR of 2.69 (1.88–3.83; P &lt; .001; I2 = 27.1%).ConclusionsThe current study showed that smoking is a significant predictor of MTX-IR, especially in disease-modifying antirheumatic drug–naïve early RA patients, as most of the included studies in the meta-analysis consisted of this population.
Oncogenic ERRB2 signals through the AP-1 transcription factor to control mesenchymal-like properties of oesophageal adenocarcinoma
Authors: Ogden Samuel , Ahmed Ibrahim , Yang Shen-Hsi , Fullwood Paul ,   the OCCAMS consortium, Francavilla Chiara , Sharrocks Andrew D 
Published: January 2023

Abstract
Oesophageal adenocarcinoma (OAC) is a deadly disease with poor survival statistics and few targeted therapies available. One of the most common molecular aberrations in OAC is amplification or activation of the gene encoding the receptor tyrosine kinase ERBB2, and ERBB2 is targeted in the clinic for this subset of patients. However, the downstream consequences of these ERBB2 activating events are not well understood. Here we used a combination of phosphoproteomics, open chromatin profiling and transcriptome analysis on cell line models and patient-derived datasets to interrogate the molecular pathways operating downstream from ERBB2. Integrated analysis of these data sets converge on a model where dysregulated ERBB2 signalling is mediated at the transcriptional level by the transcription factor AP-1. AP-1 in turn controls cell behaviour by acting on cohorts of genes that regulate cell migration and adhesion, features often associated with EMT. Our study therefore provides a valuable resource for the cancer cell signalling community and reveals novel molecular determinants underlying the dysregulated behaviour of OAC cells.
Therapeutic health effects of ginger (Zingiber officinale): updated narrative review exploring the mechanisms of action
Authors: Crichton Megan , Marshall Skye , Marx Wolfgang , Isenring Elizabeth , Lohning Anna 
Published: January 2023

AbstractGinger (Zingiber officinale) has been investigated for its potentially therapeutic effect on a range of chronic conditions and symptoms in humans. However, a simplified and easily understandable examination of the mechanisms behind these effects is lacking and, in turn, hinders interpretation and translation to practice, and contributes to overall clinical heterogeneity confounding the results. Therefore, drawing on data from nonhuman trials, the objective for this narrative review was to comprehensively describe the current knowledge on the proposed mechanisms of action of ginger on conferring therapeutic health effects in humans. Mechanistic studies support the findings from human clinical trials that ginger may assist in improving symptoms and biomarkers of pain, metabolic chronic disease, and gastrointestinal conditions. Bioactive ginger compounds reduce inflammation, which contributes to pain; promote vasodilation, which lowers blood pressure; obstruct cholesterol production, which regulates blood lipid profile; translocate glucose transporter type 4 molecules to plasma membranes to assist in glycemic control; stimulate fatty acid breakdown to aid weight management; and inhibit serotonin, muscarinic, and histaminergic receptor activation to reduce nausea and vomiting. Additional human trials are required to confirm the antimicrobial, neuroprotective, antineoplastic, and liver- and kidney-protecting effects of ginger. Interpretation of the mechanisms of action will help clinicians and researchers better understand how and for whom ginger may render therapeutic effects and highlight priority areas for future research.
Essential elements of weight loss apps for a multi-ethnic population with high BMI: a qualitative study with practical recommendations
Authors: Chew Han Shi Jocelyn , Lim Su Lin , Kim Guowei , Kayambu Geetha , So Bok Yan Jimmy , Shabbir Asim , Gao Yujia 
Published: January 2023

AbstractSmartphone weight loss apps are constantly being developed but the essential elements needed by a multi-ethnic population with overweight and obesity remains unclear. Purpose: To explore the perceptions of an Asian multi-ethnic population with overweight and obesity on the essential elements of weight loss apps. Twenty two participants were purposively sampled from a specialist weight management clinic in Singapore from 13 April to 30 April 2021. Recorded interviews were conducted using face-to-face and videoconferencing modalities. Data saturation was reached at the 18th participant. Data analysis was performed using inductive content analysis with constant comparison between and within transcripts. Findings: Three themes and eight subthemes on the essential app components emerged—(a) comprehensive and flexible calorie counters; (b) holistic, gradual and individualized behavior change recommendations tailored for people with overweight and obesity, and (c) just-in-time reminders of future consequences. There was a need to incorporate flexible options for food logging; break down general recommendations into small steps towards sustainable changes; tailor app contents for people with overweight and obesity; and evoke one’s considerations of future consequences. Future weight loss apps should be designed to meet the needs of those with overweight and obesity, the very population that needs assistance with weight loss. Future apps could consider leveraging the capacity of artificial intelligence to provide personalized weight management in terms of sustaining self-regulation behaviors, optimizing goal-setting and providing personalized and timely recommendations for weight loss.