bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value and immunological function of cuproptosis-related genes in lung adenocarcinoma
Authors: Zhang Liming , Huang Jian , Song Haixia , Wei Haixiang , Wang Shaoqiang , Wang Lina 
Published: August 2023

Abstract

Lung cancer is one of the malignant tumors with the highest morbidity and fatality rates worldwide. The overall survival (OS) of lung adenocarcinoma (LUAD) is poor. Cuproptosis is a copper-triggered modality of mitochondrial cell death, and its contribution to LUAD is unknown. The clinical implication and immunological function of cuproptosis-related genes (CRGs) in LUAD has yet to be established. TCGA, HPA, GEPIA, Kaplan-Meier, TIMER and CancerSEA database were used to explore the prognostic value and biological function of CRGs in LUAD. CRGs are primarily involved in copper ion transport, the citrate cycle (TCA cycle) and central carbon metabolism in LUAD. The mRNA expression of COA6, UBE2D1, DLAT, SLC25A3, and DBH was significantly increased. The expression of COA6, DLAT, SLC25A3, DBH, and LOXL2 were all strongly associated with the clinicopathological stages in LUAD. Moreover, high expression of COA6, UBE2D1, DLAT, SLC25A3 and LOXL2 was related to poor OS. The expression of SLC25A3 and LOXL2 showed different association with immune cell infiltration. The single cell sequencing demonstrated that CRGs play important roles in the regulation of DNA damage response, inflammation and metastasis in LUAD. This study comprehensively uncovered that CRGs could be identified as potential prognostic and immunological biomarkers in LUAD.
Alpha-glucans from bacterial necromass indicate an intra-population loop within the marine carbon cycle
Authors: Beidler Irena , Steinke Nicola , Schulze Tim , Sidhu Chandni , Bartosik Daniel , Krull Joris , Dutschei Theresa , Ferrero-Bordera Borja , Rielicke Julia , Kale Vaikhari , Sura Thomas , Trautwein-Schult Anke , Kirstein Inga , Wiltshire Karen , Teeling Hanno , Becher Dörte , Bengtsson Mia , Hehemann Jan-Hendrik , Bornscheuer Uwe , Amann Rudolf , Schweder Thomas 
Published: August 2023

Abstract
Phytoplankton blooms initiate bacterioplankton blooms, from which bacterial biomass is released via grazing zooplankton and viral lysis. Bacterial consumption of algal biomass during blooms is well studied, but little is known about the simultaneous reuse of bacterial necromass. Alpha- and beta-glucans are abundant dissolved organic macromolecules during blooms. We demonstrate algal laminarin-fueled alpha-glucan synthesis in marine Bacteroidota strains, as well as bacterial reuse of these alpha-glucans as major carbon source in vitro and during a diatom-dominated bloom. We highlight two types of genomic loci and the encoded protein machineries with structurally distinct SusD substrate-binding proteins that may target alpha-glucans of different complexities. It is demonstrated that these encoded machineries can be specifically induced by extracted alpha-glucan-rich bacterial polysaccharides. This bacterial alpha-glucan synthesis and recycling from bacterial necromass constitutes a large-scale intra-population energy conservation mechanism redirecting substantial amounts of carbon in an essential part of the microbial loop.
Phonon promoted charge density wave in topological kagome metal ScV6Sn6
Authors: Hu Yong , Ma Junzhang , Li Yinxiang , Gawryluk Dariusz , Hu Tianchen , Teyssier Jérémie , Multian Volodymyr , Yin Zhouyi , Jiang Yu-Xiao , Xu Shuxiang , Shin Soohyeon , Plokhikh Igor , Han Xinloong , Plumb Nicholas , Liu Yang , Yin Jia-Xin , Guguchia Zurab , Zhao Yue , Schnyder Andreas , Wu Xianxin , Pomajkushina Ekaterina , Hasan M Zahid , Wang Nan-Lin , Shi Ming 
Published: August 2023

Abstract
Charge density wave (CDW) orders in vanadium-based kagome metals have recently received tremendous attention due to their unique properties and intricate interplay with exotic correlated phenomena, topological and symmetry-breaking states. However, the origin of the CDW order remains a topic of debate. The discovery of ScV6Sn6, a vanadium-based bilayer kagome metal exhibiting an in-plane √3 x√3 R30° CDW order with time-reversal symmetry breaking, provides a novel platform to explore the underlying mechanism behind the unconventional CDW. Here, we combine high-resolution angle-resolved photoemission spectroscopy, Raman scattering measurements and density functional theory to investigate the electronic structures and phonon modes of ScV6Sn6 and their evolution with temperature. We identify topologically nontrivial Dirac surface states and multiple van Hove singularities (VHSs) in the vicinity of the Fermi level, with one VHS near the ꝁ point exhibiting nesting wave vectors in proximity to the √3 x√3 R30° CDW wave vector. Additionally, Raman measurements indicate a strong intrinsic electron-phonon coupling in ScV6Sn6, as evidenced by the presence of a two-phonon mode and a large frequency amplitude mode. Our findings highlight the fundamental role of lattice degrees of freedom in promoting the CDW in ScV6Sn6 and provide important insights into the fascinating correlation phenomena observed in kagome metals.
Modelling the nexus between finance, government revenue, institutional quality and sustainable energy supply in West Africa
Authors: KOLAWOLE Kayode David , ABDULMUMIN Biliqees Ayoola , uzuner Gizem , SEYINGBO Oluwagbenga Abayomi , Lukman Adebayo-Oke ABDULRAUF 
Published: August 2023

Abstract

The present study examined the relationship between finance, government revenue, institutional quality and sustainable energy supply in West Africa countries over annual frequency period from 1990 to 2020. To achieve the outlined nexus between study variables, the present study leverages on a battery of panel analysis for robust inferences. The econometric estimators employed are panel random effect regression, generalized method of moment technique. Furthermore, panel Granger causality test is utilized to analyze the direction of flow among the variables for the study. Empirical results revealed that financial development is a significant determinant of energy supply in West Africa countries while a negligible effect was reported for institutional quality and sustainable energy supply. Thus, the present study concludes that finance from financial sector is important in ensuring sufficient energy supply. To this end, this study therefore, recommends that incentives should be given to financial institutions that fund energy generation and transmission as financial development is seen to be significant on energy supply.
The Dark Triad Moderates the Effect of Winning a Competitive, Creative Problem Solving Group Task on Oxytocin but Not Cortisol
Authors: Dow Gayle , Lipatova Olga 
Published: August 2023

Abstract
The aim of this study was to evaluate changes in oxytocin and cortisol after winning or losing a competitive, group, creativity task and to determine if these changes were moderated by the Dark Triad (psychopathy, narcissism, and Machiavellianism). Oxytocin is a neuropeptide involved in the facilitation of social attachment, trust, positivity, and reduction of stress whereas cortisol is a glucocorticoid activated by stress, perceived threat, or decreases in social self-esteem. We hypothesized that, in a competitive group problem solving task, oxytocin levels would increase and cortisol levels would decrease but these effects would be lessened among those with the Dark Triad traits. To test this, 34 participants completed a Dark Triad measure then formed into small groups to compete in the spaghetti tower challenge, where the goal is to build the tallest freestanding tower that can support a marshmallow, within 18 minutes, using only hard spaghetti, string, and tape. Samples of their saliva were taken before and after the creative task, and the levels of oxytocin and cortisol in these samples were determined via enzyme-linked immunosorbent assays (ELISAs). Psychopathy (b = -.07, SE = .03, t(33) = -2.19, p = .04) Machiavellianism (b = -.04, SE = .02, t(33) = -2.14, p = .04), and Narcissism (b = -.05, SE = .02, t(33) = -2.28, p = .03) moderated the association of winning status on oxytocin while. None of the Dark Triad (psychopathy b = -.03, SE = .05, t(33) = 0.60, p = .56, narcissism b = -.01, SE = .03, t(33) = -0.33, p = .74, or Machiavellianism b = -.02, SE = .03, t(33) = -0.48, p = .64). moderated the association of winning status on cortisol. Our findings suggest that although the task was collaborative, the competitiveness and desire to win may have counteracted social bonding for those with Dark Triad tendencies. Implications and limitations are discussed.
Lectin Hemagglutination Assay of Seaweeds
Authors: VIJI VIJAYALEKSHMI , BRISCA BRISCA RENUGA 
Published: August 2023

Abstract
Lectins and Hemagglutinins are proteins/ glycoproteins, which have at least one non-catalytic domain that exhibits reversible binding to specific monosaccharides or oligosaccharides. Seaweed have lectins, which are proteins or glycoproteins of non-immune origin containing at least one non-catalytic domain that binds reversibly to specific mono or oligosaccharides. It may have been considered that binding specificity of lectins to some carbohydrates provokes to produce many unique biological activities, including cell agglutination, mitogenic activity, antibacterial activity and antitumor activity.
Androgen Deprivation Therapy for Prostate Cancer and Neurocognitive Disorders: A Systematic Review and Meta-Analysis
Authors: Hinojosa-Gonzalez David , Zafar Affan , Saffati Gal , Kronstedt Shane , Zlatev Dimitar , Khera Mohit 
Published: August 2023

Abstract
Background:
Prostate cancer is a prevalent disease that urgently needs to address its treatment-related complications. By examining existing evidence on the association between Androgen Deprivation Therapy (ADT) and dementia, this study contributes to the understanding of potential risks. We sought to analyze the currently available evidence regarding the risk of dementia, Alzheimer's disease (AD), vascular dementia, and Parkinson's disease (PD) in patients undergoing ADT.
Methods:
A systematic search of PubMed, EMBASE, Scopus, and Google Scholar was performed to identify studies published from the databases’ inception to April 2023. Studies were identified through systematic review to facilitate comparisons between studies with and without some degree of controls for biases affecting distinctions between ADT receivers and non-ADT receivers. This review identified 305 studies, with 28 meeting the inclusion criteria. Heterogeneity was assessed using Higgins I2%. Variables with an I2 over 50% were considered heterogeneous and analyzed using a Random-Effects model. Otherwise, a Fixed-Effects model was employed.
Results:
A total of 28 studies were included for analysis. Out of these, only 1 study did not report the number of patients. From the remaining 27 studies, there were a total of 2,543,483 patients, including 900,994 with prostate cancer who received ADT, 1,262,905 with prostate cancer who did not receive ADT, and 334,682 patients without prostate cancer who did not receive ADT. This analysis revealed significantly increased Hazard Ratios (HR) of 1.20 [1.11, 1.29], p < 0.00001 for dementia, HR 1.26 [1.10, 1.43], p = 0.0007 for Alzheimer's Disease, HR 1.66 [1.40, 1.97], p < 0.00001 for depression, and HR 1.57 [1.31, 1.88], p < 0.00001 for Parkinson's Disease. The risk of vascular dementia was HR 1.30 [0.97, 1.73], p < 0.00001.
Conclusion:
Based on the analysis of the currently available evidence, it suggests that ADT significantly increases the risk of dementia, AD, PD, and depression.
Not too old to rock: ESR and OSL dating methods reveal Quaternary activity of the Periadriatic Fault
Authors: Prince Erick , Tsukamoto Sumiko , Grützner Christoph , Vrabec Marko , Ustaszewski Kamil 
Published: August 2023

AbstractThe Periadriatic Fault System (PAF) ranks among the largest post-collisional structures of the European Alps. Recent Global Satellite Navigation Systems data suggest that a fraction of the Adria-Europe convergence is still being accommodated in the Eastern Alps. However, the historical seismicity records along the easternmost segment of the PAF are ambiguous and instrumental records indicate that seismotectonic deformation is mostly concentrated in the adjacent Southern Alps and adjacent Dinarides. Both Electron Spin Resonance (ESR) and Optically Stimulated Luminescence (OSL) dating methods can be used as ultra-low temperature thermochronometers. Due to their dating range (a few decades to ~ 2 Ma) and low closure temperature (below 100°C), the methods have the potential for dating shear heating during earthquakes in slowly deforming fault zones, such as the PAF. Since the saturation dose of the quartz ESR signals is larger than quartz and feldspar OSL, ESR enables establishing a maximum age of the events (assuming the resetting during seismic events was at least partial), while OSL allows finding their minimum age when the signal is in saturation. We collected fault gouge samples from 3 localities along the easternmost segment of the PAF. For ESR, we measured the signals from the Al center in quartz comparing the results from the single aliquot additive dose (SAAD) and single aliquot regenerative (SAR) protocols. For OSL, we measured the Infrared Stimulated Luminescence (IRSL) signal at 50°C (IR50) and the post-IR IRSL signal at 225°C (pIRIR225) on potassium feldspar aliquots. Our dating results indicate that the studied segment of the PAF system accommodated seismotectonic deformation within a maximum age ranging from 1075 ± 48 to 541 ± 28 ka (ESR SAR) and minimum ages in the range from 196 ± 12 to 281 ± 16 ka (pIRIR225). The obtained ages and the current configuration of the structure suggest that the studied segment of the PAF could be considered at least as a potentially active fault.
Plow tillage with straw return improved corn yield by regulating canopy light interception and N distribution
Authors: Meng Xiangzeng , Zhang Shan , Wang Yongjun , Wang Lichun , Gao Hongjun , Lv Yanjie 
Published: August 2023

Abstract
Straw return offers an effective way to achieve soil sustainability. However, there is a limited amount of research addressing the impact of nitrogen application and straw return method on the vertical distribution of crop canopy and nitrogen allocation. The experiment was based on a long-term field experiment that started in 2011 and was conducted at the Halahai Comprehensive Experimental Station in Nong'an County, Jilin Province. Sampling was carried out in 2021 and 2022 to analyse the canopy distribution and nitrogen allocation of the maize hybrid Fumin 985 under two straw returning methods, no tillage with straw mulch (SM) and plow tillage with straw return (SP), and five nitrogen application rates: 0 (N0), 90 (N90), 150 (N150), 210 (N210), and 270 kg N ha− 1 (N270). The present study indicated that under a nitrogen application rate below N150, the yield was on average 11.66% − 24.34% higher in SP than in SM. This difference was mainly attributed to the variation in 1000-grain weight. Furthermore, SP maintained a higher leaf area index (LAI) and total radiation interception rate (RIR) during the grain filling stage with the same nitrogen application rate compared to SM. It also significantly increased post–flowering dry matter accumulation by 8.87% − 69.26% compared to SM. Additionally, SP significantly improved the proportion of grain dry weight and led to an increase of 10.35% − 16.04% in 1000-grain weight compared to SM. Moreover, SM increased the relative nitrogen content in grain, which in turn improved nitrogen uptake efficiency (NUpE) and grain nitrogen use efficiency (NUE). Finally, SP demonstrated a synergistic enhancement in yield and NUE under lower nitrogen application rates than SM. In summary, the combination of SP with nitrogen fertilizer application proves to be an effective method to achieve high yield and high efficiency maize production compared to SM.
Nutrition-immune-inflammation score (NIIS) plays an important role in the prognosis of external auditory canal carcinoma after surgery
Authors: Cheng Hao , Xu Jin-Hong , Li Yi-Hao , Wang Jing-Jing , Hao Meng-Di , He Jia-Qi , Xu Xue-Lian 
Published: August 2023

Abstract
Background
External auditory canal carcinoma (EACC) was a rare malignant tumor. This study was designed to investigate the relationship between the nutrition-immune-inflammation score (NIIS) and the prognosis of patients with resectable EACC.
Methods
A total of 45 resectable EACC patients diagnosed between July 2012 and May 2018 were enrolled from two medical institutions, and retrospectively reviewed. Kaplan–Meier method was used to estimate survival rates. Log-rank test was used to assess the impact of NIIS and other prognostic variables on overall survival (OS) and progression-free survival (PFS). Univariate analyses were performed by using the Cox risk regression method.
Result
All 45 patients underwent surgical resection, and 17 of them received postoperative radiotherapy. The 3-year and 5-year overall survival (OS) for the EACC patients was 68.9% and 57.7%, respectively. The 3-year and 5-year progression-free survival (PFS) for the EACC patients were 55.6% and 51.1%, respectively. Local recurrence (LR) occurred in 16 (35.6%) patients. 12 (26.7%) patients had distant metastasis (DM). NIIS was calculated from body mass index (BMI), C-reactive protein (CRP), lymphocytes, albumin, and hemoglobin. Univariate analysis showed that NIIS (P = 0.005), Pittsburgh stage Ⅲ-Ⅳ (P = 0.017), nerve invasion (P < 0.001), and positive surgical margin (P = 0.002) were significant factors for PFS in EACC patients. In the statistics of OS, we found that NIIS (P = 0.004), Pittsburgh stage Ⅲ-Ⅳ (P = 0.010), nerve invasion (P < 0.001), and radiotherapy (P = 0.041) were significant factors.
Conclusion
Our findings suggest that NIIS is an important biomarker that affects the prognosis of postoperative ESCC patients. In addition, for patients with resectable EACC, the absence of postoperative radiotherapy, advanced stage, positive surgical margins, and nerve invasion had a negative impact on prognosis.
Patterns of care at the end of life: A retrospective study of Italian patients with advanced breast cancer.
Authors: Giannubilo Irene , Battistuzzi Linda , Blondeaux Eva , Ruelle Tommaso , Poggio Francesca Benedetta , Buzzatti Giulia , D’Alonzo Alessia , Rovere Federica Della , Latocca Maria Maddalena , Molinelli Chiara , Razeti Maria Grazia , Nardin Simone , Arecco Luca , Perachino Marta , Favero Diletta , Borea Roberto , Pronzato Paolo , Mastro Lucia Del , Bighin Claudia 
Published: August 2023

Abstract
Objectives
To better understand the type of care offered to Italian patients with advanced breast cancer at the End-of-Life (EoL), we conducted a retrospective observational study. EoL was defined as the period of six months before death.
Methods
One hundred and twenty-one patients with advanced breast cancer (ABC) treated at IRCCS San Martino Policlinic Hospital who died between 2017 and 2021 were included. Data about patient, disease, and treatment characteristics from breast cancer diagnosis to death, along with information about comorbidities, medications, imaging, specialist evaluations, hospitalization, palliative care and home care, hospice admissions, and site of death were collected.
Results
98.3% of the patients received at least one line of active treatment at EoL; 52.8% were hospitalized during the selected period of time. Palliative (13.9%), psychological (7.4%), and nutritional evaluations (8.2%) were underutilized. Palliative home care was provided to 52% of the patients. Most of the patients died at home (66.1%) and fewer than one out of five (18.2%) died at the hospital. Among the patients who died at home, 27.3% had no palliative support.
Conclusions
Our findings indicate that palliative care in EoL breast cancer patients is still inadequate. Only a minority of patients did access to Psychological and nutritional support While low nutritional support may be explained by the fact that typical symptoms of ABC do not involve the gastrointestinal tract, the lack of psychological support suggests that significant barriers still exist. Data on the site of death are encouraging, indicating that EoL management is increasingly home-centered in Italy.
Oral administration of resveratrol reduces oxidative stress generated in the hippocampus of Wistar rats in response to consumption of ethanol
Authors: Navarro-Cruz Addí Rhode , Juárez-Serrano Daniel , Arteaga Iván Cesar , Kammar-García Ashuin , Vera-López Obdulia , Lazcano-Hernández Martin , Pérez-Xochipa Ivonne , Badilla Orietta Segura 
Published: August 2023

Abstract

Chronic ethanol intake has been found to favor hippocampal deteriorationand alter neuronal morphological maturation; resveratrol has been suggested as an antioxidant that may counteract these effects.The objective of this work was to analyze the effect of resveratrol on oxidative stress markers and the endogenous antioxidant system in the hippocampus of Wistar rats administered ethanol. In this experimental study, we worked with male Wistar rats, 3 months old that were randomly assigned to control, Ethanol, or to Resveratrol groups for 2 months. Subsequently, the production of nitrites, malondialdehyde and 4-hydroxy-alkenal as well as the enzymatic activity of SOD and CAT were quantified. Levels of nitric oxide and lipid peroxidation products were significantly increased when ethanol concentration was increased compared to the control group, however, resveratrol treatment significantly reduced oxidative stress caused by high ethanol intake. The enzymatic activity studied did not present significant changes with respect to the controls. The results showed that there is a decrease in oxidative stress markers when resveratrol is administered in high alcohol consumption. It is concluded that resveratrol prevents oxidative stress induced by ethanol in the hippocampus by decreasing cellular lipid peroxidation, but not the activation of catalase and superoxide dismutase enzymes.
Digital Banking Financial Business Innovation Research and Index Analysis Focused on Collaborative Filtering Recommendation
Authors: Fu Haoran , Li Huahui 
Published: August 2023

Abstract
Collaborative filtering recommendation is a technology that has rapidly appeared in information filtering and information systems in recent years. At present, it is widely used in commercial activities and has achieved very satisfactory results. The research of this article is based on the basic operating system method and the suggestion of the automatic recognition system (collaborative filtering recommendation), that is, customers purchase fixed deposits. Based on behavioral theory and new institutional arrangements, this article explores the influence and effect of the external development of external digital banks on the digital behavior of traditional commercial banks, and concludes that the development of digital banks has a positive impact on bank operations and product differentiation innovation. The economic pressure brought about by the development of digital banks first promoted the bank's product innovation, while the social pressure mechanism affected the bank's digital innovation in management and production. Social pressure has an impact on bank management and digital innovation. The improvement of financial business transparency and the diversification of financial products have also increased competition in the financial market. Accurately predicting customer preferences is crucial for financial business companies. The development of an effective classification model will not only help increase company profits, but also effectively reduce costs. In the user-based collaborative filtering system research algorithm, by establishing a time-series-based consumer network, determine the targeted influence relationship between users to find the neighbor set more accurately, and establish a time-series-based collaborative filtering algorithm to improve recommendation the accuracy of the algorithm.