bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of future haemorrhage from cerebral cavernous malformations: a retrospective cohort study
Authors: Gillespie Conor S. , Alnaham Khalifa E. , Richardson George E. , Mustafa Mohammad A. , Taweel Basel A. , Islim Abdurrahman I. , Hannan Cathal John , Chavredakis Emmanuel 
Published: February 2023

AbstractCerebral cavernous malformations (CCMs) are commonly diagnosed, with a low reported rate of haemorrhage on long-term follow-up. The identification of factors predictive of future haemorrhage risk would assist in guiding the management of patients with CCM. The aim of this study was to identify variables associated with haemorrhage, and calculate haemorrhage risk in CCM. We conducted a retrospective study of patients diagnosed with a CCM, managed at a specialist tertiary neuroscience centre (2007–2019). The primary outcome was symptomatic haemorrhage, and secondary outcomes were variables associated with increased risk of haemorrhage, using multivariable Cox regression analysis. Included were 545 patients, with 734 confirmed cavernomas. Median age at diagnosis was 47 (interquartile range [IQR] 35–60), with a median follow-up duration after diagnosis of 46 months (IQR 19–85). Of the patients, 15.0% had multiple lesions (N = 82/545). Symptomatic presentation was observed in 52.5% of patients (N = 286/545). The annual haemorrhage rate was 1.00% per lesion-year (25 events in 2512 lesion-years), and higher in those with symptoms at presentation (1.50% per lesion-year, 22 events vs 0.29%, 3 events, P < 0.001). The variables associated with symptomatic haemorrhage were increased size (hazard ratio [HR] 1.04, 95% confidence interval [CI] 1.01–1.07, P = 0.004), eloquent location (HR 2.63, 95% CI 1.12–6.16, P = 0.026), and symptomatic haemorrhage at presentation (HR 5.37, 95% CI 2.40–11.99, P < 0.001). This study demonstrated that CCMs have a low haemorrhage rate. Increased size, eloquent location, and haemorrhage at presentation appear to be predictive of a higher risk of haemorrhage, and could be used to stratify management protocols.
Die Deindustrialisierung Deutschlands: berechtigte Sorge oder German Angst?
Authors: Falck Oliver , Pfaffl Christian 
Published: February 2023

AbstractThe shrinking of the German manufacturing sector due to the new energy crisis is currently a hotly debated topic. The aim of this article is to contribute to this emotional debate by providing evidence on recent developments in the German manufacturing sector. The analysis of relevant data concludes that this debate is fueled by infamous German angst rather than hard facts.
Industriestandort Deutschland droht struktureller Verlust an Wettbewerbsfähigkeit
Authors: Heymann Eric 
Published: February 2023

AbstractThe current energy crisis poses major economic growth risks for the German economy as a whole and for German industry in particular. It also represents an enormous structural challenge for Germany as an industrial nation. A comprehensive deindustrialization in Germany across all sectors is unlikely. One argument against this is the adaptability of German industry. The prospects for some industrial sectors have become significantly gloomier, however, as a result of the acute energy crisis and higher gas and energy prices in the medium term.
Akademie ehrt einen „weit verbreiteten Irrtum“
Authors: Bofinger Peter 
Published: February 2023

ZusammenfassungDer Preis der Schwedischen Reichsbank für Wirtschaftswissenschaften im Gedenken an Alfred Nobel geht an Ben Bernanke, Douglas Diamond und Philip Dybvig. Nach Ansicht der Königlich Schwedischen Akademie der Wissenschaften haben die Preisträger „unser Verständnis der Rolle der Banken in der Wirtschaft erheblich verbessert“. Doch da irren sie.
Die Bürgergeld-Reform aus Sicht der Jobcenter
Authors: Osiander Christopher , Ramos Lobato Philipp 
Published: February 2023

ZusammenfassungMit der jüngst vom Bundestag beschlossenen Einführung eines Bürgergelds soll die Grundsicherung für Arbeitsuchende zum Jahresbeginn 2023 reformiert werden. Die Reform steht dabei nicht allein für eine begriffliche Abkehr von „Hartz IV“, sondern beansprucht eine „grundlegende Weiterentwicklung“ des Sicherungssystems. So sollen nachhaltige Arbeitsmarktintegration und Qualifizierung gestärkt, vor allem aber das Verhältnis des Sozialstaats zu seinen unterstützungsbedürftigen Bürger:innen von Grund auf neujustiert werden. Die praktische Umsetzung obliegt den mehr als 400 Jobcentern. In einer Online-Befragung wurde vorab ihre Einschätzung der Reform erhoben.
The FIND Program: Improving Follow-up of Incidental Imaging Findings
Authors: Zaki-Metias Kaitlin M. , MacLean Jeffrey J. , Satei Alexander M. , Medvedev Serguei , Wang Huijuan , Zarour Christopher C. , Arpasi Paul J. 
Published: February 2023

AbstractIncidental findings are findings identified on imaging which are unrelated to the original reason for examination and require follow-up. The Radiology Finding Incidental Disease (FIND) Program was designed to track and improve follow-up of incidental imaging findings. The purpose of this study was to determine the frequency of incidental findings on cross-sectional imaging and the adherence to suggested follow-up of incidental findings prior to and after implementation of a structured reporting and tracking system. A retrospective analysis of 2000 patients with computed tomographic cross-sectional imaging was performed: 1000 patients prior to implementation of the FIND Program and 1000 patients 1 year after establishment of the program. Data collected included the frequency of incidental findings, inclusion of follow-up recommendations in the radiology report, and adherence to suggested follow-up. There was a higher rate of completion of recommended follow-up imaging in the post-implementation group (34/67, 50.7%) compared to the pre-implementation (16/52, 30.8%) (p = 0.03). Implementation of an incidental findings tracking program resulted in improved follow-up of incidental imaging findings. This has the potential to reduce the burden of clinically significant incidental findings possibly resulting in later presentation of advanced disease.
Contrast analysis in ultrafast ultrasound blood flow imaging of jugular vein
Authors: Omura Masaaki , Yagi Kunimasa , Nagaoka Ryo , Hasegawa Hideyuki 
Published: February 2023

Abstract
Purpose
The contrasts of flowing blood in in vitro experiments using porcine blood and in vivo measurements of human jugular veins were analyzed to demonstrate that the hemorheological property was dependent on the shear rate.

Methods
Blood samples (45% hematocrit) suspended in saline or plasma were compared with examine the difference in viscoelasticity. Ultrafast plane-wave imaging at an ultrasonic center frequency of 7.5 MHz was performed on different steady flows in a graphite-agar phantom. Also, in vivo measurement was performed in young, healthy subjects and patients with diabetes. A spatiotemporal matrix of beamformed radio-frequency data was used for the singular value decomposition (SVD) clutter filter. The clutter-filtered B-mode image was calculated as the amplitude envelope normalized at the first frame in the diastolic phase to evaluate contrast. The shear rate was estimated as the velocity gradient perpendicular to the lateral axis.

Results
Although nonaggregated erythrocytes at a high shear rate exhibited a low echogenicity, the echogenicity in the plasma sample overall increased due to erythrocyte aggregation at a low shear rate. In addition, the frequency of detection of specular components, defined as components beyond twice the standard deviation of a contrast map obtained from a clutter-filtered B-mode image, increased in the porcine blood at a high shear rate and the venous blood in healthy subjects versus patients with diabetes.

Conclusion
The possibility of characterizing hemorheological properties dependent on the shear rate and diabetes condition was indicated using ultrafast plane-wave imaging with an SVD-based clutter filter.
Development of a Head Acceleration Event Classification Algorithm for Female Rugby Union
Authors: Powell David R. L. , Petrie Freja J. , Docherty Paul D. , Arora Hari , Williams Elisabeth M. P. 
Published: February 2023

AbstractInstrumented mouthguards have been used to detect head accelerations and record kinematic data in numerous sports. Each recording requires validation through time-consuming video verification. Classification algorithms have been posed to automatically categorise head acceleration events and spurious events. However, classification algorithms must be designed and/or validated for each combination of sport, sex and mouthguard system. This study provides the first algorithm to classify head acceleration data from exclusively female rugby union players. Mouthguards instrumented with kinematic sensors were given to 25 participants for six competitive rugby union matches in an inter-university league. Across all instrumented players, 214 impacts were recorded from 460 match-minutes. Matches were video recorded to enable retrospective labelling of genuine and spurious events. Four machine learning algorithms were trained on five matches to predict these labels, then tested on the sixth match. Of the four classifiers, the support vector machine achieved the best results, with area under the receiver operator curve (AUROC) and area under the precision recall curve (AUPRC) scores of 0.92 and 0.85 respectively, on the test data. These findings represent an important development for head impact telemetry in female sport, contributing to the safer participation and improving the reliability of head impact data collection within female contact sport.
Spore dispersal patterns of the ascomycete fungus Ramularia collo-cygni and their influence on disease epidemics
Authors: Havis N. D. , Kaczmarek J. , Jedryczka M. , Hess M. , Fang Z. 
Published: February 2023

AbstractRamularia leaf spot is a major economic disease of barley caused by the dothidiomycete fungus Ramulariacollo-cygni. The fungus has a complex life cycle which includes extensive late season spore release events and a seed-borne phase. Predicting disease epidemics during the growing season remains a difficult challenge. To better understand the interaction between spore movement and disease epidemics, spore samplers were set up in Germany (two sites over 4 years), Poland (seven sites over 2 years) and the UK (two sites over 9 years), where the disease has been observed. Spore concentrations were determined using a real time PCR assay, and meteorological data were obtained from co-located automatic stations. Spore release events were seen to peak in June on mainland Europe and July in the UK. The pattern of spore release was broadly similar across countries with earlier peaks in mainland Europe. A relationship was observed in the UK between July spore levels and disease in following winter barley crops. Rainfall and temperature were proposed as significant drivers of spore release in these months. The major environmental parameter associated with spore release across the two UK sites was crop surface wetness, although some site-specific interactions were noted for rainfall and wind movement. Regression analysis of spore patterns and disease epidemics indicates a relationship between spore levels 75–105 days pre harvest and final disease levels in UK winter barley crops. This relationship was not observed in spring barley. The implications on risk forecasts are discussed.
Mental Health Literacy for Supporting Children: A Systematic Review of Teacher and Parent/Carer Knowledge and Recognition of Mental Health Problems in Childhood
Authors: Johnson Catherine L. , Gross Maxine A. , Jorm Anthony F. , Hart Laura M. 
Published: February 2023

AbstractThe level of mental health literacy (MHL) in adults who work with or care for children is likely to influence the timeliness and adequacy of support that children receive for mental health problems. The aim of this study was to systematically review the literature on mental health literacy for supporting children (MHLSC, recognition/knowledge) among parents and teachers of school aged children (5 to 12 years old). A systematic search was conducted for quantitative studies published between 2000 and June 2021 using three databases (MEDLINE, PsycINFO and ERIC) and relevant citations reviewed in Scopus. To be included, studies needed to measure at least either ‘mental health knowledge’ or ‘recognition’. Synthesis proceeded according to study design, adult population, child MHP, then MHL outcome. Study quality was assessed using AXIS. 3322 documents were screened, 39 studies met inclusion criteria. 49% of studies examined teachers’ knowledge or recognition of ADHD; only five studies reported on parent samples. Synthesis found a nascent field that was disparate in definitions, methods and measures. Little research focussed on knowledge and recognition for internalizing problems, or on parents. Methods used for measuring knowledge/recognition (vignette vs screening) were associated with different outcomes and the quality of studies was most often low to moderate. Adults appear to have good recognition of childhood ADHD but their knowledge of internalizing disorders is less clear. Further research is required to develop standard definitions and validated measures so gaps in MHLSC can be better identified across populations who have a role in supporting children with their mental health.
Pyrolysis of tea and coffee wastes: effect of physicochemical properties on kinetic and thermodynamic characteristics
Authors: Ben Abdallah Asma , Ben Hassen Trabelsi Aïda , Navarro María Victoria , Veses Alberto , García Tomás , Mihoubi Daoued 
Published: February 2023

AbstractPhysicochemical properties, kinetic pyrolysis and thermodynamic study of spent green tea, pure spent coffee grounds, spent coffee grounds blended with 50% torrefied barley and coffee husk were experimentally investigated using thermogravimetric analysis under an inert atmosphere to evaluate their thermochemical application. Five isoconversional methods were applied to determine effective activation energy (Ea) of the pyrolysis processes. All methods showed good agreement by determining fluctuating Ea values (150–500 kJ mol−1). Complex Ea profiles with conversion were divided into four stages corresponding to thermal degradation of main biomass constituents (extractives, hemicellulose, cellulose and lignin), indicating that extractives decomposition was the least demanding reaction while lignin decomposition was the most demanding. The kinetic process was verified by reconstruction according to the Friedman parameters. The thermodynamic parameters were evaluated to determine the energy demand and efficiency throughout the process. The values obtained for physicochemical properties such as volatile matter (> 68%) and higher heating value (> 17 MJ kg−1), average Ea (223–319 kJ mol−1) and significant energy efficiency implied that these types of biomass waste have significant reactivity and consequently the highest potential for the production of bioenergy and a range of high-value chemicals and materials.
Hedging cryptocurrency options
Authors: Matic Jovanka Lili , Packham Natalie , Härdle Wolfgang Karl 
Published: February 2023

AbstractThe cryptocurrency market is volatile, non-stationary and non-continuous. Together with liquid derivatives markets, this poses a unique opportunity to study risk management, especially the hedging of options, in a turbulent market. We study the hedge behaviour and effectiveness for the class of affine jump diffusion models and infinite activity Lévy processes. First, market data is calibrated to stochastic volatility inspired-implied volatility surfaces to price options. To cover a wide range of market dynamics, we generate Monte Carlo price paths using an stochastic volatility with correlated jumps model, a close-to-actual-market GARCH-filtered kernel density estimation as well as a historical backtest. In all three settings, options are dynamically hedged with Delta, Delta–Gamma, Delta–Vega and Minimum Variance strategies. Including a wide range of market models allows to understand the trade-off in the hedge performance between complete, but overly parsimonious models, and more complex, but incomplete models. The calibration results reveal a strong indication for stochastic volatility, low jump frequency and evidence of infinite activity. Short-dated options are less sensitive to volatility or Gamma hedges. For longer-dated options, tail risk is consistently reduced by multiple-instrument hedges, in particular by employing complete market models with stochastic volatility.
Unlocking the connection between education, entrepreneurial mindset, and social values in entrepreneurial activity development
Authors: Patrício Lurdes D. , Ferreira João J. 
Published: February 2023

AbstractThe Entrepreneurial University constitutes a phenomenon that highlights the prominent roles played by academic organizations as aggregators of capabilities, enabling the establishing of bridges between innovation and Entrepreneurial Ecosystems. This research therefore sets out to analyze the relationship between the Total Early Stage Entrepreneurial Activities of individual graduates and their entrepreneurial attitudes and social values towards entrepreneurship. This applies data sourced from the Global Entrepreneurship Monitor report on innovation-driven countries. The main research findings stem from the regression models (Study 1) and fsQCA analysis (Study 2) returning evidence that the likelihood of adult graduates setting up firms or owning young companies rises whenever such individuals deem they hold the knowledge/skills required to start a business. The results also stress the importance of devoting high levels of media attention to entrepreneurship and fostering entrepreneurial cultures capable of fostering economic growth and prosperity. This research makes substantial theoretical contributions to the literature. Firstly, the findings reinforce the applicability and suitability of fsQCA analysis of Global Entrepreneurship Monitor data. Secondly, this study strengthens the credibility of the Institutional Theory and Theory of Planned Behavior theoretical frameworks, correspondingly lending support to the importance of institutional or organizational factors as determinants of entrepreneurship and the need to focus on the linkage between entrepreneurial attitudes, entrepreneurial intentions, and entrepreneurial behaviors.
Haltung zeigen, haben, lernen …
Authors: Georg Eva 
Published: February 2023

ZusammenfassungDer Beitrag lädt zum Nachdenken über den Begriff Haltung und Handlung ein. Die Auseinandersetzung mit Haltung im Bereich Diskriminierung und rechter Gewalt gehört zur Ausbildung von Professionalität in der Sozialen Arbeit. Diese Themen werden anhand der Ergebnisse einer Praxisforschung aufgegriffen.
Pleomorphic Adenoma of Nasal Septum a Case Report
Authors: Tang Guangjun , Du Bo , Lan Youxing , Tian Li 
Published: February 2023

Abstract
Introduction
Pleomorphic adenoma is a common benign tumor of large and small salivary glands. It mainly occurs in the parotid gland, followed by the submandibular gland, sublingual gland and small salivary gland in the oral cavity. It is very rare in the nasal septum.

Patient Concerns
A 27-year-old female patient attended our clinic with Nasal congestion and a diminished sense of smell.

Diagnoses
Endoscopic examination revealed a mass within the right nasal passage. A pathological biopsy revealed pleomorphic adenoma.

Interventions
The nasal septum pleomorphic adenoma was resected by endoscopic approach.

Outcomes
No recurrence was observed for over 41 months of follow-up.

Conclusion
To prevent recurrence, extensive local resection with clear histological margins and long-term endoscopic follow-up with an endoscope are necessary.
Is Politeness Better than Impoliteness? Comparisons of Robot's Encouragement Effects Toward Performance, Moods, and Propagation
Authors: Higashino Kana , Kimoto Mitsuhiko , Iio Takamasa , Shimohara Katsunori , Shiomi Masahiro 
Published: February 2023

AbstractThis study experimentally compared the effects of encouragement with polite/ impolite attitudes from a robot in a monotonous task from three viewpoints: performance, mood, and propagation. Experiment I investigated encouragement effects on performance and mood. The participants did a monotonous task during which a robot continuously provided polite, neutral, or impolite encouragement. Our experiment results showed that polite and impolite encouragement significantly improved performance more than neutral comments, although there was no significant difference between polite and impolite encouragement. In addition, impolite encouragement caused significantly more negative moods than polite encouragement. Experiment II determined whether the robot's encouragement influenced the participants' encouragement styles. The participants behaved similarly to the robot in Experiment I, i.e., they selected polite, neutral, and impolite encouragements by observing the progress of a monotonous task by a dummy participant. The experiment results, which showed that the robot's encouragement significantly influenced the participants' encouragement styles, suggest that polite encouragement is more advantageous than impolite encouragement.
SLIT3 knockdown inhibited TGF-β-induced hepatic stellate cells activation by down-regulating YAP signal
Authors: Fu Xiling , Chang Jiabao , Jiao Damin , Zhu Mengying , Ma Yuqi 
Published: February 2023

Abstract
Objective
Liver fibrosis is a chronic liver disease caused by a variety of pathophysiological. However, there are no effective treatments to combat it. HSCs are a major source of fibrotic cells and exploring the mechanisms of HSC activation may provide new strategies for the treatment of liver fibrosis.

Objectives
To explore the role and underlying mechanism of SLIT3 in HSCs fibrosis.

Results
GSE163211 dataset analysis identified aberrant expression of SLIT3 in NASH F1-F4 tissues and SLIT3 expression level was positively correlated with fibrosis-related proteins. In vitro experiments showed that TGF-β induced upregulation of SLIT3 in LX-2 cells. Knockdown of SLIT3 significantly inhibited TGF-β-induced α-SMA, COL1A2, and COL1A1 expression, inhibited excessive cell proliferation and migration, and suppressed YAP activity.

Conclusion
Collectively, our findings suggest that SLIT3 deficiency alleviates TGF-β-induced HSCs activation by inhibiting YAP activity.