bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary diffuse leptomeningeal atypical teratoid/rhabdoid tumours (ATRT) of childhood: a molecularly characterised case report and literature review
Authors: Stivaros S. M. , Parkes L. M. , Bedir R. , Cheesman E. , Ram D. , Leung L. , Huang A. , Kilday J. P. 
Published: January 2025

Abstract

Background
Atypical teratoid/rhabdoid tumours (ATRTs) are malignant central nervous system tumours, typically presenting in the posterior fossa of very young children. Prognosis remains poor despite current therapy, while tumorigenesis implicates both genomic and epigenetic dysregulation. Primary diffuse leptomeningeal (PDL) ATRT, characterised by the absence of an intraparenchymal mass lesion, is seldom reported but appears associated with a dismal outcome.

Case presentation
We describe a 7-year-old male presenting with a PDL MYC-subgroup ATRT. The patient received multimodal upfront therapy, including high-dose craniospinal radiotherapy, embedded within a chemotherapy backbone. An unexpected clinical and radiological improvement was also observed upon cessation of all therapy for presumed disease progression. Although the patient eventually succumbed to the disease at 30 months, he demonstrated the longest survival for any PDL ATRT patient reported (median 8 months).

Conclusion
Exhaustive literature review identified seven preceding published cases of PDL ATRT. Ours is the only one to have molecular subgrouping assigned. Perfusion imaging, within a multi-parametric diagnostic package, may be a sensitive marker for malignancy against other aetiologies in challenging presentations. Acknowledging the scarcity of the entity, we cautiously suggest a combination of chemotherapy and upfront high-dose craniospinal radiotherapy, if appropriate, may prolong survival for older children with PDL ATRT compared to exclusive chemotherapy or focal irradiation-based strategies. Our patient’s recovery during palliation following a radiological diagnosis of disseminated relapse highlights the importance of confirming disease recurrence by tissue extraction where feasible.
Genome size variation and whole-genome duplications in the monocot order Poales
Authors: Winterfeld Grit , Tkach Natalia , Röser Martin 
Published: January 2025

Abstract
Nuclear genome sizes of 54 representative species from 44 genera of the monocot order Poales were investigated by flow cytometry. Small holoploid genomes with < 2 pg/2C are characteristic of the Poales; only some families have larger 2C values, although this is not consistently the case. The sizes of monoploid genomes as well as mean DNA content per chromosome (MC) show a similar pattern. A comparison of the genome size data with current molecular phylogenetic data suggests that small monoploid genomes (1Cx < 0.4 pg) and small chromosomes (MC ≤ 0.05 pg), as found in some families, are likely the ancestral features of the order Poales. Conspicuous increases in genome size occurred particularly in the Poaceae (grasses) and to a lesser extent in the xyrid clade and the Restionaceae. According to previous phylogenomic studies, the Poaceae are characterized by a whole-genome duplication (WGD) called ρ, which is absent in all other Poales families. However, it is clear from the 1Cx values that the ρ event is not, or no longer, associated with a significant increase in the minimum 1Cx genome sizes of grasses compared to other Poales families. Future studies need to clarify whether the smallest 1Cx values in the Poaceae are due to a secondary reduction of the nuclear genome after the ρ event and whether the relatively large minimal 1Cx values of the xyrid clade were caused by a further WGD within Poales.
Efficacy of Ceftazidime-avibactam in treating Gram-negative infections: a systematic review and meta-analysis
Authors: Khoshdel Nahal , Noursalehigarakani Melina , Seghatoleslami Zahra Sadat , Hadavand Fahimeh , Eghbal Elaheh , Nasiri Mohammad Javad , Simula Elena , Ahmed Parnian , Sechi Leonardo Antonio 
Published: January 2025

Abstract

Introduction
Ceftazidime-avibactam (CAZ-AVI) has emerged as a promising treatment option for Gram-negative infections, particularly those caused by CAZ-Non-Susceptible (NS) pathogens. This systematic review and meta-analysis aim to assess the efficacy and safety of CAZ-AVI in these challenging infections.

Methods
We systematically queried EMBASE, Cochrane CENTRAL, and PubMed/Medline for studies published until September 15, 2024. Randomized Controlled Trials (RCTs) evaluating CAZ-AVI against Gram-negative infections were included. A meta-analysis was performed to calculate pooled odds ratios (OR) for both clinical and microbiological success.

Results
A total of 146 studies were identified through database searches, leading to the inclusion of 17 studies. Among the efficacy studies for Gram-negative pathogens, there was no significant difference in clinical success rates for CAZ-AVI compared to comparators (pooled OR: 0.90, p = 0.22), and a non-significant increase in microbiological success was observed (pooled OR: 1.20, p = 0.41). In contrast, for CAZ-NS pathogens, six studies reported no significant difference in clinical cure rates (pooled OR: 0.77, p = 0.24), while four studies indicated a non-significant increase in microbiological cure rates (pooled OR: 1.83, p < 0.02).

Conclusions
This study suggests that CAZ-AVI is a viable option for treating Gram-negative infections, including CAZ-NS pathogens. While it has shown promising activity against these resistant pathogens, its clinical and microbiological success rates are comparable to other antibiotics in the overall analysis. However, CAZ-AVI may offer an advantage in managing resistant infections. These findings underscore the need to consider CAZ-AVI in treatment guidelines and emphasize the importance of antibiotic stewardship programs to optimize its use and prevent resistance. Ongoing monitoring of resistance patterns and patient outcomes is essential to ensure its long-term efficacy.
Implied dividend bounds in option prices: anatomy of two markets
Authors: Cherubini Umberto , Mulinacci Sabrina 
Published: January 2025

Abstract
We propose a measure of uncertainty of a dividend paying asset based on the cross-section of bid-ask spreads of options. This is the difference between the cheapest synthetic long position of the asset that it is possible to construct using European options and the most expensive short position that can be constructed at the same time for the same maturity. For index and stock option applications this measure can be compared with other direct measures of uncertainty such as the bid-ask spread of the futures market on the underlying or their dividend. It turns out that for index options the measure is tighter than the bid-ask spread of the futures market for maturities longer than the first two futures contracts. The comparison of the measure for individual stock options with dividend futures gives mixed results. Finally, applying a two-tail distortion (2TD) model we find an asymmetric setting of option ask and bid prices with respect to the reference model. Most of the distortion is loaded on the ask call price and bid put prices. This corresponds to asymmetric uncertainty in dividend yield expectations, which put more weight on low dividends.
Under the spotlight: contextualizing the firm vs. industry debate through the introduction of neighborhood effects
Authors: Vedula Siddharth , Fitza Markus , Purkayastha Anish , Ellsaesser Florian 
Published: January 2025

Abstract
The relative importance of firm and industry effects, contrasting resource-based and industrial organization theories, is often discussed in the strategy and international business literature. Several studies indicate that firm effects (i.e., variability in firm-specific internal resources) are the primary drivers of competitive differences between firms. Leveraging insights from several theoretical lenses such as location economics, relational strategy, and institutional theory, we argue that considering the micro-geographic locations (neighborhoods) of firms challenges two implicit but potentially unrealistic assumptions in the firm vs. industry effects academic debate: That (a) firm boundaries are clearly defined, and (b) industry effects are spatially homogenous. We argue that including a neighborhood and neighborhood-industry interaction effect is thus more appropriate to contextualize the classic firm vs. industry debate. We demonstrate that firm effects are much smaller than previously identified (e.g., dropping from 43.9 to 11.5%). Our results thus challenge conventional wisdom and established empirical findings, while adding nuance to the fundamental debate regarding the locus of competitive advantage of firms.
Promoting soft skills in higher engineering education: Assessment of the impact of a teaching methodology based on flipped learning, cooperative work and gamification
Authors: Sanz-Angulo Pedro , Galindo-Melero Jesús , De-Diego-Poncela Santiago , Martín Óscar 
Published: January 2025

Abstract
In the dynamic and complex environment of industrial engineering, soft skills have become fundamental elements to achieve professional success. This work analyzes (i) how industrial engineering students at the University of Valladolid in Spain perceive the effect of a teaching methodology (characterized by a sound and systematic integration of Information and Communication Technologies (ICT) in all phases of the teaching–learning process and based on the combination of Flipped Learning, cooperative work and gamification), on the development of their soft skills, and (ii) the relationship between this development of soft skills and academic performance. Voluntary surveys were applied to students of seven engineering degrees during four academic years. Data collected have been analyzed by means of graphical and statistical techniques to obtain a deep and rigorous understanding of the impact of teaching methodology. The results show a positive perception by students of the effect of teaching methodology. It is not only a motivating element that improves participation but, moreover, students perceive that it significantly contributes to the development and enhancement of skills such as communication, teamwork, problem solving, critical thinking and the effective use of ICT. In addition, the positive influence of these competencies on academic performance was evidenced. This work identifies several key aspects related to the results obtained: (i) the synergies achieved by combining Flipped Learning with cooperative work and gamification; (ii) the importance of face-to-face activities and encouraging students' active participation; (iii) the outstanding effect of the appropriate integration of ICT on the results; (iv) the adaptation of teaching to the needs of each group of students; and (v) the fundamental role of monitoring and continuous improvement of methodology as pillars to guarantee its long-term effectiveness and to overcome any challenges that may arise.
Social aspects in the pathway towards the closure of a dumpsite: the case of Ngong (Kenya)
Authors: Villa Francesca , Dias Sonia Maria , Masese Jane Bosibori Oteki , Sitoki Lewis , Miheso Duncan , Grosso Mario 
Published: January 2025

Abstract
Dumpsites are a common way for waste disposal around the world. Since their impact is not controlled, they represent a threat to the public health and to the environment, being a source of pollutants and greenhouse gases. The dumpsite of Ngong (Kajiado County, Kenya) has been addressed since years as a serious issue affecting the surrounding community. A project for its closure and the establishment of a new facility for waste treatment was elaborated in 2017, and recently the conversion of the dumpsite in a park has been proposed by the local authorities. Nonetheless, the framework appears still complex from the environmental, economic and social points of view: any intervention is expected to raise challenges for the municipal solid waste management (MSWM) system in place, which involves many stakeholders, including informal workers of the dumpsite. After presenting a general overview on the MSWM system in place at the time, this paper presents the results of the social assessment (SA) carried out in 2018, where some of the criticalities encountered by the local authorities at a later time were already predicted. In the opinion of the authors, the importance of qualitative and sociological research within a technological project is highlighted by the results of the SA, and the shared methodology can be helpful for practitioners on the field, whose support will enhance the capacity of stakeholders to deal successfully with challenges related to waste management.
Co-creation in higher education: a conceptual systematic review
Authors: Omland Maren , Hontvedt Magnus , Siddiq Fazilat , Amundrud Anja , Hermansen Hege , Mathisen Maiken A. S. , Rudningen Gudrun , Reiersen Frederik 
Published: January 2025

Abstract
Co-creation constitutes a novel pedagogical approach for enhancing teaching and learning in higher education. When students and staff collaborate to improve curriculum, pedagogical resources, and the development of students’ roles as peer-mentors or teaching assistants, it has led to increased learning outcomes, more inclusive practices, empowered students, and improved relationships between students and staff. In this conceptual systematic review of 222 research articles, we investigate characteristics of research on co-creation and analyse how the interactions constituting co-creation have been conceptualised. We identified dialogue, positioning, agency, and voice as core concepts describing co-creational interactions. These concepts are highly interconnected and were examined both as products of co-creation and as vital elements for co-creation to be productive. Based on these findings, we developed an analytical framework serving (a) to inform analyses of co-creational interaction and (b) as a model for educators designing co-creational activities. We further contribute to the theoretical underpinning of co-creation by discussing how dialogic theories can inform investigations of co-creational interactions in future research. We argue that there is a range of research questions related to the interactions constituting co-creation that are not sufficiently investigated. We suggest that future research should be directed towards observational studies of these interactions to develop knowledge on how educators can interact inclusively with students, fostering agency and positioning students as significant contributors to educational processes in higher education.
Caves of Fortune? Gendered Labour Precarity and Securitisation Involving the ‘Wild’ Edible Birds’ Nest Trade in Kapuas Hulu, Indonesia
Authors: Dunphy Mia B. , Toumbourou Tessa D. , Dressler Wolfram H. , Hasudungan Albert , Utomo Ariane 
Published: January 2025

Abstract
Harvesting edible birds’ nests (EBN) produced by swiftlets from caves and purpose-built dwellings has generated a new high-value, non-timber forest product-based livelihood for rural smallholders across Indonesia. Drawing on extended fieldwork, we explore the gendered labour and livelihood outcomes for households transitioning from EBN cave harvesting to domestication in West Kalimantan, Indonesia. Following calls from feminist political ecology, we investigate the more visible ‘men’s work’ associated with EBN access and labour and highlight women’s pivotal, yet often overlooked, role in managing the associated household incomes and land-based livelihoods. We show how the increasing demand for ‘wild’ EBN drove significant changes in the ownership rights of caves in the region, securitisation and scarcity of the nests, and the rise in precarious labour conditions. The increasing demand for ‘wild’ EBN has intensified extraction and securitisation of caves and nests, and the precarity of work for Dayak men working as cave guards and harvesters. In response, many Dayak women—who receive and manage their husbands’ salaries—saved to scale up their household’s EBN production using purpose-built swiftlet farmhouses. Both spouses’ labour contributions were integral to securing a sustained source of income through the EBN trade, enabling income diversification and a more hopeful future for rural households.
Reclaiming Agency: a Community-Based Model for Women Overcoming Intimate Partner Violence
Authors: Ben-Porat Anat , Lir Shlomit Aharoni 
Published: January 2025

Abstract

Purpose
Although shelters represent a primary instrument for governmental intervention in the worldwide endeavor to aid women survivors of intimate partner violence (IPV), an alternative approach to assist such women involves establishing community-based programs. In this qualitative study, we examined an Israeli pilot of a community-based program offering professional support to women survivors of IPV, using an empowerment model. Questions regarding whether and how the program helped the participants leave the cycle of violence, and whether the program met their needs, were explored.

Methods
The study was based on two focus group meetings with 21 women who participated in the program and shared their experiences, four months into the program and one year after its initiation.

Results
The findings resulted in the conceptualization of a five-stage model: Name, Trust, Learn, Reclaim, and Maintain. The model stages mirror the process through which the women, empowered by the intervention, regained control over their lives.

Conclusions
The study offers an effective intervention that can be applied to women IPV survivors who need assistance in the community, and emphasizes the need for a variety of programs for this population in accordance with their different needs.
Existence of Long-Range Order in Random-Field Ising Model on Dyson Hierarchical Lattice
Authors: Okuyama Manaka , Ohzeki Masayuki 
Published: January 2025

Abstract
We study the random-field Ising model on a Dyson hierarchical lattice, where the interactions decay in a power-law-like form,

$$J(r)\sim r^{-\alpha }$$

J

(
r
)

∼

r

-
α

, with respect to the distance. Without a random field, the Ising model on the Dyson hierarchical lattice has a long-range order at finite low temperatures when

$$1<\alpha <2$$

1
<
α
<
2

. In this study, for

$$1<\alpha <3/2$$

1
<
α
<
3
/
2

, we rigorously prove that there is a long-range order in the random-field Ising model on the Dyson hierarchical lattice at finite low temperatures, including zero temperature, when the strength of the random field is sufficiently small but nonzero. Our proof is based on Dyson’s method for the case without a random field, and the concentration inequalities in probability theory enable us to evaluate the effect of a random field.
Item-Level Analysis of Category Fluency Test Performance: A Systematic Review and Meta-Analysis of Studies of Normal and Neurologically Abnormal Ageing
Authors: De Marco Matteo , Wright Laura M. , Makovac Elena 
Published: January 2025

Abstract
While Category Fluency (CF) is widely used to help profile semantic memory, item-level scoring (ILS) approaches to this test have been proposed to obtain indices that are less influenced by non-semantic supportive functions. We systematically reviewed the literature to test the hypotheses that (1) compared with healthy adults, individuals with a clinical diagnosis suggestive of neurodegeneration generate words of lower semantic complexity; (2) compared with young adults, older adults generate words of higher semantic complexity. We searched six databases (date of search: 8 December 2023) for studies that relied on CF and ILS methods, in normal ageing and in age-associated neurodegeneration. Thirty-four studies were shortlisted: 27 on neurodegenerative conditions; 7 on normal ageing. Risk of bias was evaluated via a published checklist. Data were presented via qualitative synthesis. Most studies reported words of lower semantic complexity in relation to at least one item-level feature in individuals with mild cognitive impairment (MCI), Alzheimer’s dementia (AD), and other neurodegenerative diseases. Post-hoc meta-analyses focussing on the MCI/AD continuum confirmed an effect on words’ frequency (385 MCI/AD individuals and 350 controls; Hedges’s G = 0.59) and age-of-acquisition (193 MCI/AD individuals and 161 controls; Hedges’s G =  − 1.51). Studies on normal ageing, conversely, failed to demonstrate any overall effect. Most studies on MCI and AD have not relied on neurobiological diagnostic criteria. Moreover, only a small number of studies analysed ILS controlling for quantitative CF performance. Despite these two limitations, this study suggests that ILS can contribute to an in-depth characterisation of semantic memory in neurological ageing.
Dynamics of Contaminant Flow Through Porous Media Containing Random Adsorbers
Authors: Pettersson Kaj , Nordlander Albin , Sasic Kalagasidis Angela , Modin Oskar , Maggiolo Dario 
Published: January 2025

Abstract
Many porous media are mixtures of inert and reactive materials, manifesting spatio-chemical heterogeneity. We study the evolution of scalar transport in a chemically heterogeneous material that mimics a green roof soil substrate, fractionally composed of inert and reactive adsorbing particles. These adsorbing particles are equivalent to biochar within a real soil substrate. The scalar transport evolution is determined using experiments and simulations calibrated from experimental data. Experiment 1 is used to determine the equilibrium capacity and adsorption rate of two biochar types when immersed in a methylene blue solution. Breakthrough curves of a packed bed of glass beads with randomly interspersed biochar are determined in experiment 2. Simulations are then run to investigate the solute transport and adsorption dynamics at the pore-scale. An analytical model is proposed to capture the behavior of the biochar adsorption capacity, and the simulation results are compared with experiment 2. A pore-scale analysis showed that uniformly sized beds are superior in contaminant breakthrough reduction, which is related to the adsorptive surface area and the rate at which adsorption capacity is reached. Cases using the adsorption capacity model display a tight distribution of particle surface concentration at later simulation times, indicating maximum possible adsorption. The beds with dissimilar particle sizes create more channeling effects which reduce adsorptive particle efficiency and consequently higher breakthrough concentration profiles. Comparison between experiments and simulations show good agreement. Improved biochar performance can be achieved by maintaining particle size uniformity alongside high adsorption capacity and adsorption rates appropriate to the rainfall intensity.