bluuebunny/crossref_metadata_2025_split huggingface dataset:
â€œKONSULTINGâ€ DAN DAMPAKNYA TERHADAP HASIL KINERJA MANAJEMEN PT. BANK MUAMALAT INDONESIA CABANG DARMO SURABAYA
Authors: Muflihin M. Dliyaul 
Published: July 2023

Berkembangnya perbankan di Indonesia tidak terlepas dari manajemen resiko yang menjadi faktor utama berjalannya perbankan. Penelitian ini bertujuan untuk mengetahui implementasi konsulting di PT. Bank Muamalat Indonesia Cabang Darmo Surabaya dan mengetahui dampak konsulting terhadap hasil kinerja manajemen PT. Bank Muamalat Indonesia Cabang Darmo Surabaya. Data penelitian ini terhimpun dari wawancara secara langsung dengan auditor internal PT. Bank Muamalat Indonesia Cabang Darmo Surabaya serta data laporan keuangan PT. Bank Muamalat Indonesia selanjutnya dianalisis dengan metode analisis deskriptif analisis. Hasil penelitian ini menyimpulkan bahwa Dampak konsulting terhadap hasil kinerja ditunjukkan oleh rasio Return on Assets (ROA), Return on Equity (ROE), Non Performing Finance (NPF), Financing Deposit Ratio (FDR), dan Rasio Efisiensi Operasional (REO). diperoleh hasil bahwa konsulting ini berdampak positif pada rasio Return on Equity (ROE), Non Performing Finance (NPF), Financing Deposit Ratio (FDR), dan Rasio Efisiensi Operasional (REO). Sedangkan pada rasio Return on Assets (ROA) konsulting berdampak negatif. Dari hasil kesimpulan tersebut hendaknya aktivitas konsulting ini lebih dipublikasikan melalui diklat-diklat dan pelatihan-pelatihan agar audit dengan konsulting ini lebih dikenal dan digunakan sebagai metode baru.
Relationship of <i>SLCO1B1</i> and <i>ABCB1</i> gene polymorphisms with clinical variants of methotrexate toxicity in pediatric acute lymphoblastic leukemia therapy
Authors: Gurieva О. D. , Savelyeva М. I. , Sozaeva Zh. A. , Valiev Т. T. 
Published: July 2023

Background. Despite the significant clinical efficacy of current treatment protocols for acute lymphoblastic leukemia (ALL) in children, high-dose methotrexate demonstrates significant interindividual variability in drug toxicity and disease outcomes due to polymorphisms of drug transporter genes and genes responsible for cytostatic metabolism, which makes pharmacogenetic studies increasingly relevant.Aim. To evaluate the association of ABCB1 (C3435T rs1045642, rs1128503, rs2032582, rs4148738), SLCO1B1 T521C rs4149056 gene polymorphisms with the main types of methotrexate toxicity and the onset of clinical events (death, recurrence, progression) during the treatment of childhood ALL.Materials and methods. The study enrolled 103 patients diagnosed with ALL who received therapy according to BFM group protocols (2002/2009), using high-dose (2000 and 5000 mg/m2) methotrexate. Laboratory methods using NCI toxicity scales (CTCAE v5.0 2018) were used to assess adverse reactions. Real-time polymerase chain reaction method was used to study ABCB1 and SLCO1B1 gene polymorphisms. The study material was peripheral blood. Material was sampled once, regardless of the duration of methotrexate therapy. SPSS Statistics 21.0 software was used for statistical processing of the results. Analysis of associations was performed using the χ2 criterion and Fisher’s exact test.Results. Development of infectious complications, oropharyngeal mucositis, delayed MTX elimination, events were significantly associated with polymorphisms of the studied genes: SLCO1B1 T521C rs4149056, ABCB1 rs4148738, ABCB1 rs1128503, which correlates with the data of world scientific literature.Conclusion. Determination of polymorphisms of genes responsible for the transport and metabolism of methotrexate is a promising and dynamically developing area of clinical oncology.
Assessing radonotherapy effectiveness and modulated steroidogenesis in experimental chronic endometritis model
Authors: Chernova A. E. , Remneva O. V. , Bobrov I. P. , Lepilov A. V. , Mazko O. N. , Makarova O. G. , Semenikhina N. M. , Rozhkova O. V. , Grebtsov I. V. , Baranov D. A. , Antonova S. A. , Baranova V. V. 
Published: July 2023

Aim: to evaluate therapeutic efficacy and modulated steroidogenesis after radon therapy in experimental chronic endometritis model.Materials and Мethods. A therapeutic effect related to radon mineral waters was studied experimentally. The water radon concentration was 5.4–6.2 nCi/dm3. The experimental endometritis was induced in laboratory Wistar line rats (n = 40) inoculated with intra-uterine self-fecal suspension. Experimental group animals (n = 10) received a wide-spectrum antibiotic Ceftriaxone within 7 days followed by applying 10 procedures of radon therapy one a day and from day 41, the first procedure lasting 5 minutes, the second – 8 minutes, the third – 10 minutes, with all other procedures – for 15 minutes. Comparison group I animals (n = 10) received antibacterial therapy, radon therapy and 10 procedures of peloid therapy with natural salt-saturated medium sulfide silt therapeutic mud according to a radon therapy regimen. Сomparison group II (n = 10) received antibacterial and peloid therapy according to comparison group I regimen. Control group (n = 10) received no treatment. Inflammatory signs were assessed by endometrium histology study. The venous steroid hormones levels were analyzed by enzyme-linked immunosorbent assay.Results. In experimental vs. control group, it was found that endometrial diffuse infiltrate was of lower density comprising 125.4 ± 8.1 vs. 180.7 ± 9.0 immunocompetent cells (by 30.7%; p = 0.002), whereas in comparison group I, density of inflammatory infiltration was minimal (reduced by 88.7 % compared to control group; p < 0.001) and reached 20.5 ± 1.8 cells. In the experimental group as well as comparison groups I and II vs. control group, a significant increased level of serum progesterone was observed after treatment (p = 0.008). When using a radon therapy in experimental group, it resulted in a more prominent rise in progesterone level compared to peloid therapy in comparison group II. Radon balneotherapy was found in main control group to elicit a significant declined estradiol level (p = 0.008), but not in comparison groups I and II featured with no significant change in estradiol level compared to control group.Conclusion. Radon therapy exerts an anti-inflammatory effect in experimental chronic endometritis model. Radon therapy combined with peloid therapy has a potentiated effect. The use of radon balneotherapy is accompanied by significantly increased progesterone and decreased estradiol level suggesting to conduct clinical trials for confirming its effectiveness in patients with reproductive dysfunction including diseases accompanied by hyperestrogenism.
In gait kinematics, structural equation modeling produces models for female gait attractiveness
Authors: TANABE Hiroko , YAMAMOTO Kota 
Published: July 2023

Abstract
In our social lives, movement’s attractiveness greatly affects interpersonal cognition, and gait kinematics mediates walkers’ attractiveness. However, no model using gait kinematics has so far predicted gait attractiveness. Thus, this study constructed models of female gait attractiveness with gait kinematics and physique factors as explanatory variables for both barefoot and high-heel walking. First, using motion capture data from 17 women walking, including seven professional runway models, we created gait animations. We also calculated the following gait kinematics as candidate variables to explain walking’s attractiveness: four body-silhouette-related variables and six health-related variables. Then, 60 observers evaluated each gait animation’s attractiveness and femininity. We performed correlation analysis between these variables and evaluation scores to obtain explanatory variables. Structural equation modeling suggested two models for gait attractiveness, one composed of trunk and head silhouette factors and the other of physique, trunk silhouette, and health-related gait factors. The study’s results deepened our understanding of mechanisms behind nonverbal interpersonal cognition through physical movement and brought us closer to realization of artificial generation of attractive gait motions.
Performance evaluation of in-house developed Covid-19 IgG/IgM antibody rapid diagnostic kit
Authors: G Vinaya Chandu Vidya Sagar , V Janardhan Reddy P , Suravajhala Prashanth , Suravajhala Renuka , V Uday Kiran , TC Venkateswarulu , PB Kavi Kishor , Polavarapu Rathnagiri 
Published: July 2023

Abstract
In the interest of preventing the Coronavirus Disease 2019 (COVID-19) pandemic from spreading, it is crucial to promptly identify and confine afflicted patients. Serological antibody testing is a significant diagnostic technique that is increasingly employed in clinics, however its clinical use is still being investigated. A meta-analysis was carried out to scrutinize how well Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibody testing using in-house developed rapid antibody assay worked for diagnosing COVID-19 patients against the chemiluminescence (CLIA) assay. IgG- positive but IgM-negative (IgG-, IgM+); IgG-positive but IgM-negative (IgG+, IgM-); IgM+ IgG+; both IgM-positive and IgG-positive (IgM+IgG+); and either IgM-positive or IgG-positive (IgM+ or IgG+) have been evaluated. A total of 300 samples with diverse age and sexual identity data were included. The combined sensitivities for IgG+IgM+, IgM+IgG-, IgG+IgM- and negative were evaluated. More accurate diagnostic results may be obtained using molecular diagnostic tools. The Antibody Rapid Diagnostic kit's (in-house developed) performance was satisfactory for determining the presence of Covid-19 infection with IgG and IgM positivity. The IgG and IgM positivity helped evaluate the immune response in the individual for the COVID-19 infection. These results lend support to the additional utilisation of serological antibody tests in the COVID-19 diagnosis.
Necessity of a Global Patient co-Owned Cloud (GPOC)
Authors: Lidströmer Niklas , Davids Joe , ElSharkawy Mohamed , Herlenius Eric , Ashrafian Hutan 
Published: July 2023

Abstract
Global conflicts and crises significantly affect all forms of healthcare delivery, evidenced by the COVID-19 pandemic and wars. Mass migration results in the displacement of millions of people without any access to their personal health records (PHRs). To improve access to health records for everyone, anywhere in the world, cloud-based healthcare infrastructures for PHRs need to be evaluated. This to manage significant chronic conditions such as ischaemic heart disease, diabetes, and cancer, missing out on quality routine and planned care. Cloud based PHRs would also enable both patients’ co-ownership and a research platform in the era of artificial intelligence in medicine. This has not previously been the subject of scientific focus.

Here we present the results of the first Global Patient co-Owned Cloud (GPOC) structured survey and a consensus summit. The survey was answered by key opinion leaders from all 193 United Nations’ (UN) member states, 2 UN observer states (Holy See & Palestine) and 1 de facto UN non-member state (Taiwan) with additional input from 18 top-ranked, international organisations. The survey identified twelve major facets that require research attention.

Based on the feedback and results, we also assessed the necessity and feasibility of developing a GPOC paradigm. This consists of evidenced-based scientific principles in accordance with ethical, economic, technical, legal, and international regulatory considerations. Through this we investigate a globally inclusive foundation structure using personal health records as the fulcrum for effective cross-border collaborative healthcare.
The clinical characteristics and therapeutic outcomes of adult patients with community- acquired spontaneous bacterial meningitis with a fulminant clinical course in Taiwan
Authors: CY Lien , Chien Chun-Chih , Lu Cheng-Hsien , Chang Wen-Neng 
Published: July 2023

Abstract
Purpose
To examine the clinical characteristics of adult patients with community-acquired spontaneous bacterial meningitis (CASBM) with a fulminant clinical course.
Material and methods
The clinical features and therapeutic outcomes of 127 adult CASBM patients were analyzed. The patients were divided into two groups as those with and without a fulminant clinical course. Fulminant clinical course was defined as meningitis presenting initially with marked consciousness disturbance (Glasgow Coma Scale score < 8) or a rapid deterioration in consciousness level within 48 h of hospitalization.
Results
Among the 127 enrolled patients, 69 had a fulminant clinical course (47 men and 22 women) and 58 did not. The patients with a fulminant clinical course had a significantly higher incidence of end-stage renal disease (ESRD), severe clinical manifestations and higher mortality rate, and the survivors had significantly worse therapeutic outcomes. Klebsiella (K.) pneumoniae (50 strains) was the most important pathogen for the development of a fulminant clinical course, and all strains were susceptible to ceftriaxone and ceftazidime. With treatment, 50.7% (35/69) of the patients with a fulminant clinical course died, and the presence of K. pneumoniae infection was significant prognostic factor.
Conclusions
The presence of ESRD, initial presentation of altered consciousness, septic shock, seizures and CSF total protein level and K. pneumoniae infection were significantly associated with a fulminant clinical course of adult CASBM, and patients with this specific infectious syndrome had high mortality and morbidity rates. The presence of K. pneumoniae infection is a significant prognostic factor.
Baseline toxicological assessment of biliary PAHs and heavy metals contamination in a commercially consumed native fish (Mugil cephalus) within Fiji coastal waters
Authors: Varea Rufino , Piovano Susanna , Mani Francis 
Published: July 2023

Abstract

The indirect exposure and effects of marine pollutants such as heavy metals and polycyclic aromatic hydrocarbons, present significant health concerns for human coastal communities that rely on fish consumption as a regular nutritional source. This study confirms a sentinel marine fish species,Mugil cephalus(“mullet”), for biomonitoring environmental health and conducting risk assessments using biomarkers in Fiji. Sampling was performed at two Fijian study areas, i.e., Laucala Bay and the Ba River Delta. Findings suggest that mullets from Laucala Bay exhibit biochemical responses that reflect a better habitat condition than those from the Ba River Delta. The lower K factor supports this conclusion, and HSI was observed in mullets from Laucala Bay. Analyses of polycyclic aromatic hydrocarbons revealed higher concentrations of four metabolites (naphthalene, phenanthrene, 1-hydroxypyrene, and benzo[a]pyrene) in samples from the Ba River Delta compared to Laucala Bay, with some metabolites showing statistically significant differences between the two sites. Four heavy metals (Cd, Cr, Pb, and Hg) were quantified in edible fish tissues of mullet from both study areas. The concentrations of Cr and Pb were higher in mullets from the Ba River Delta than in Laucala Bay, but below the safety limits set by the World Health Organization for human consumption. Cd and Hg concentrations were below the detection limits. Biotransformation processes (phase I and II) were assessed using ethoxyresorufin O-deethylase and glutathione S-transferase as biomarkers. The enzyme cascade of antioxidants, specifically glutathione peroxidase and glutathione reductase, demonstrated effectiveness and potential as biomarkers for future studies. Measuring lipid peroxidation and erythrocyte nuclei abnormalities provided evidence of higher levels of biological damage in mullet from the Ba River Delta compared to Laucala Bay. These findings 1) support the use of mullet as a suitable reference species for future ecotoxicology studies in Fiji, 2) are essential to take informed health and safety considerations regarding mullet consumption, 3) provide a baseline to compare future monitoring results and, 4) underscore the importance of incorporating biomonitoring practices in future environmental risk assessments. Doing so can establish a robust and comprehensive ecotoxicological framework to inform future environmental policies and legislation in Fiji.
Preliminarily Experimental Study on Servo Control Strategy for Dry Electrical Discharge Machining
Authors: Li Liqing , Wang Yunhang , Chen Yitao 
Published: July 2023

Abstract
In traditional liquid EDM, huge carbon emissions, and the process is not environmentally friendly. The emergence of electric discharge machining in gas (DEDM) has unfolded a new situation of sustainable development of EDM. However, the problems of poor discharge stability and low machining efficiency have restricted the application of DEDM. Considering that servo control is an important factor affecting the discharge state and machining performance, while related research is rarely reported up to now, we make an exploratively study on the servo control of DEDM to understand its feature and aim to improve the discharge stability and machining efficiency. The relative discharge ratio, machining efficiency, electrode wear and surface roughness with different control strategies were compared and analyzed using a self-built ball screw EDM servo system, and obtained a more effective improvement compared with traditional servo strategy in DEDM. It is found that PD control strategy improved the effective discharge ratio by 40.4% and machining efficiency by 136.55% compared with conventional control strategy. This work also analyzed the servo characteristics under different gas media (oxygen, nitrogen, argon) and putted forward servo optimization scheme, the experimental results verified the effectiveness of improving DEDM from servo strategy, which indirectly proved the matching characteristics of medium and servo in EDM.
Tear biomarkers for Alzheimer’s disease screening and diagnosis (The TearAD study): design and rationale of an observational longitudinal multicenter study
Authors: de Sande Nienke van , Ramakers Inez H.G.B. , Visser Pieter Jelle , Verhey Frans R.J. , Verbraak Frank D. , Bouwman Femke H. , Berendschot Tos T.J.M. , Nuijts Rudy M.M.A. , Webers Carroll A.B. , Gijs Marlies 
Published: July 2023

Abstract
Background: Alzheimer’s disease (AD) is the most common cause of dementia, and due to increasing life expectancy the number of patients is expected to grow. The diagnosis of AD involves the use of biomarkers determined by an amyloid PET scan or cerebrospinal fluid analyses that are either invasive or expensive, and not available in each hospital, thus limiting their usage as a front-line screener. The TearAD study aims to use tear fluid as a potential source for AD biomarkers. In previous reports, we demonstrated that AD biomarkers amyloid-beta and tau, are measurable in tear fluid and are associated with disease severity and neurodegeration. This study aims to validate previous results in a larger cohort and evaluate the diagnostic accuracy of tear biomarkers to discriminate between individuals with and without neurodegeneration as determined by hippocampal atrophy.
Methods: The TearAD study is an observational longitudinal multi-center study that will enroll 50 cognitively healthy controls, 50 patients with subjective cognitive decline, 50 patients with mild cognitive impairment and 50 patients with AD dementia from the memory clinic. Participants will be examined at baseline, after one year, and after two years follow-up. Study assessments include neuropsychological tests and ophthalmic examination. All participants will receive a MRI scan, and a subset of the study population will undergo cerebral spinal fluid collection and an amyloid PET scan. Tear fluid will be collected with Schirmer strips and levels of Aβ38, Aβ40, Aβ42, t-tau and p-tau in tear fluid will be determined using multiplex immunoassays. Blood samples will be collected from all participants. Images of the retina will be obtained with a standard, hyperspectral and ultra-wide field fundus camera. Additionally, macular pigment optical density will be measured with the macular pigment reflectometer, and cross-sectional images of the retina will be obtained through optical coherence tomography imaging.
Discussion: The TearAD study will provide insight into the potential diagnostic use of tear biomarkers as a minimally invasive and low cost tool for the screening and diagnosis of AD.
Trial registration: Retrospectively registered at clinicaltrails.gov (NCT05655793).
High-sensitive cardiac Troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy
Authors: Zhang Meng , Gao Wei , Cui Xiaotong , Han Xueting , Xu Yamei , Zhou Jingmin , Ge Junbo 
Published: July 2023

Abstract

Background: Apical hypertrophic cardiomyopathy (AHCM) is a subtype of hypertrophic cardiomyopathy (HCM). The expression level of high-sensitive cardiac troponin T (hs-cTNT) and N-terminal pro-BNP (NT-proBNP) in AHCM patients, and these relationships between echocardiography parameters were still unclear.
Methods: We retrospectively screened AHCM patients between January 2019 and December 2021 in Zhongshan Hospital Fudan University. The relationship between the level of hs-cTNT, NT-proBNP and echocardiography parameters were analyzed. The risk factors for elevated hs-cTNT and NT-proBNP level were investigated with linear regression analysis.
Results: A total of 267 AHCM patients were enrolled. They were divided into hs-cTNT normal (129, 48.3%) and abnormal (138, 51.7%) group. Compared with hs-cTNT normal group, hs-cTNT abnormal group were elder (68.3±11.6 vs. 63.8±10.6, P=0.001); with higher rate of atrial fibrillation (AF) (41.3% vs. 17.8%, P<0.001) and higher level of NT-proBNP concentration (752.0 [343.8-1345.5] vs. 249.0 [104.0-541.0], P<0.001). For echocardiography parameters, hs-cTNT abnormal patients have thicker interventricular septum (IVS) (11.6±2.0 vs. 11.0±1.7, P=0.02), thicker left ventricular apical (LVA) (16.9±3.0 vs. 14.9±2.3, P<0.001) and larger left atrium diameter (LAD) (45.9±6.6 vs. 42.4±5.1, P<0.001). LVA was independently correlated with both the level of hs-cTNT and NT-proBNP (hs-cTNT r=0.224, P=0.143; NT-proBNP r=0.370, P<0.001). Linear regression analysis revealed that LVA was independent risk factor of both the elevated hs-cTNT and NT-proBNP level.
Conclusion: More than half of AHCM patients had abnormal hs-cTNT level. LVA was positively and independently correlated with the level of hs-cTNT and NT-proBNP.
X-Ray Dynamical Diffraction by Quasi-Monolayer Graphene
Authors: Skakunova Olena S. , Olikhovskii Stepan I. , Radchenko Taras M. , Lizunova Svitlana V. , Vladimirova Tetyana P. , Lizunov Vyacheslav V. 
Published: July 2023

Abstract
We study the processes of dynamical diffraction on the graphene film/SiC substrate system. The statistical dynamical theory of X-ray diffraction in imperfect crystals is extended to the case of real quasi-two-dimensional systems. The necessity of the taking into account of the variability of the lattice parameter of multilayer graphene, as well as the influence of thickness on the thermal Debye–Waller factor at the calculation of the complex structural factors and Fourier components of polarizability, is demonstrated. It is shown that the change of the structural characteristics of the 3-layer graphene/substrate system, as well as its deformed state, leads to a significant change in the diffraction profiles, which makes it possible to determine the characteristics by the X-ray diffraction method.