bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological implications of humane endings on the veterinary profession
Authors: Kollias Nathaniel S. , Strand Elizabeth B. , Kogan Lori R. , Houlihan Kendall E. , Thompson-Iritani Sally , Hoenig Donald E. , Ng Zenithson Y. , Hart Lynette A. 
Published: January 2023

Abstract
The veterinary profession has a unique responsibility to animals during the final stages of their lives. The veterinarian’s obligations extend to humane endings, involving all species of animals in a range of circumstances including, but not limited to, euthanasia of individually owned animals, euthanasia of animals for research purposes, depopulation of animals during emergencies, and slaughter of animals raised for food. The veterinary profession continues to improve animal welfare through advances in end-of-life decision-making and humane killing techniques,1–3 but the psychological impacts on veterinarians have not received the same level of consideration. Building on the influential AVMA Humane Endings Guideline, the AVMA recognizes that support for the mental health of veterinarians engaged in such activities needs to be a priority. This article aims to provide the foundation and rationale for improved preparation and establishment of sustainable mental health resources and to offer recommendations on pragmatic solutions to support and prepare veterinary professionals as leaders impacted by participation in humane endings–related activities. While end-of-life decision-making and implementation may present mental health challenges to veterinarians, it is crucial to recognize that there are stressors specific to each situation and that every individual’s experience is valid. Addressing the mental health issues surrounding the decision-making process and implementation of humane endings activities start with a comprehensive understanding of each activity’s unique context and the veterinarian’s leadership role. Therefore, this article highlights the psychological impact of depopulation and its similarities and exclusive challenges compared with euthanasia and humane slaughter.
Recent approaches in the drug research and development of novel antimalarial drugs with new targets
Authors: Chinnappanna Naveen Kumar Reddy , Yennam Gopi , Chaitanya Chaitanya Budagam Haima Naga Venkata , Pottathil Shinu , Borah Pobitra , Venugopala Katharigatta N. , Deb Pran Kishore , Mailavaram Raghu Prasad 
Published: January 2023

Abstract
Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. There are several approaches to developing antimalarial drugs, ranging from alterations of current drugs to the creation of new compounds with specific targeting abilities. The availability of multiple genomic techniques, as well as recent advancements in parasite biology, provides a varied collection of possible targets for the development of novel treatments. A number of promising pharmacological interference targets have been uncovered in modern times. As a result, our review concentrates on the most current scientific and technical progress in the innovation of new antimalarial medications. The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. The new cellular targets and drugs which can inhibit malaria and their development techniques are summarised in this study.
Intensive critical care and management of asthmatic and smoker patients in COVID-19 infection
Authors: Lu Dongming , Yaqoob Obaid , Kumar Manish , Kushwah Ajay Singh , Sharma Rahul Kumar , Kumar Devinder , Mavai Yogendra , Khan Rukaiya 
Published: January 2023

Abstract
This century’s most serious catastrophe, COVID-19, has been dubbed “the most life-threatening disaster ever”. Asthmatic persons are even more prone to COVID-19’s complex interplay with the underlying inflammatory condition. In order to protect themselves against COVID-19, asthmatic patients must be very vigilant in their usage of therapeutic techniques and drugs (e.g., bronchodilators, 5-lipoxygenase inhibitors), which may be accessed to deal with mild, moderate, and severe COVID-19 indications. People with asthma may have more severe COVID-19 symptoms, which may lead to a worsening of their condition. Several cytokines were found to be elevated in the bronchial tracts of patients with acute instances of COVID-19, suggesting that this ailment may aggravate asthma episodes by increasing inflammation. The intensity of COVID-19 symptoms is lessened in patients with asthma who have superior levels of T-cells. Several antibiotics, antivirals, antipyretics, and anti-inflammatory drugs have been suggested to suppress COVID-19 symptoms in asthmatic persons. Furthermore, smokers are more likely to have aggravated repercussions in COVID-19 infection. Being hospitalized to critical care due to COVID-19, needing mechanical breathing, and suffering from serious health repercussions, are all possible outcomes for someone who has previously smoked. Smoking damages airways and alveoli, which significantly raises the risk of COVID-19-related health complications. Patients with a previous record of smoking are predisposed to severe COVID-19 disease symptoms that essentially require a combination of bronchodilators, mucolytics, antivirals, and antimuscarinic drugs, to cope with the situation. The present review discusses the care and management of asthmatic and smoker patients in COVID-19 infection.
Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods
Authors: Kashiwagura Yasuharu , Takusagawa Shota , Ikematsu Yasuyuki , Tanaka Shimako , Namiki Noriyuki , Uchida Shinya 
Published: January 2023

Abstract
This study aimed to elucidate the characteristics and pharmacokinetics of orally disintegrating tablets (ODTs) containing coenzyme Q10 (CoQ10) granules prepared by spray drying, hot-melting, and wet granulation. The hardness and disintegration times of CoQ10-ODTs containing 5 % crospovidone were 61.6–81.8 N and < 30 s, respectively; these values indicate that the as-prepared ODTs were adequate for clinical use. The hardness and disintegration times of all ODTs did not change significantly after a 28-day storage period at 30 °C/10 % relative humidity (RH), but storage under high temperature and humidity affected their characteristics. The dissolution and pharmacokinetics of CoQ10-ODTs showed that ODTs prepared using the spray-drying method had the highest dissolution and absorbability among the CoQ10-ODTs tested. These results provide useful information for the preparation of ODTs using CoQ10.
Network Condition-Aware Enhanced Distributed Channel Access for IEEE 802.11e Wireless Ad-Hoc Networks
Authors: Mammar Soulimane , Haffaf Hafid , Rahmouni Kamel 
Published: January 2023

Abstract
The increasing use of multimedia applications in wireless ad-hoc networks makes the support of quality of service (QoS) an overriding necessity. In this article, we present a new extension of the IEEE 802.11e EDCA scheme called NCA-EDCA, which uses the lifetime and the number of retransmissions attempts of a packet to assess the aggressiveness of the environment in order to adjust the channel access parameters to work in the best possible way and improve service quality accordingly. This new extension aims to (1) improve the performance of real-time applications; (2) increase the overall throughput by reducing the collision rate and (3) achieve an acceptable level of fairness. The simulation results show that our extension significantly improves EDCA for better QoS support of multimedia applications. More specifically, it increases throughput of the different flows by no negligible factors and significantly reduces the collision rate while maintaining a high degree of fairness between flows of equal priority.
Perancangan Produk Coffee Table dengan Memanfaatkan Material Bonggol Jagung
Authors: Ramdini Zahra Nuriafadsa , Izzah Nurrul , Masri Andry 
Published: January 2023

Penelitian ini merupakan perancangan furnitur berupa coffee table dengan memanfaatkan karakteristik material bonggol jagung sebagai material utama yang berfungsi sebagai meja untuk mengisi interior rumah bonggol jagung yang diletakkan atau ditempatkan pada bagian teras rumah bonggol jagung untuk aktivitas bersantai. Penelitian ini dilakukan melalui pendekatan identifikasi secara menyeluruh, pembuatan konsep, implementasi konsep, dan diakhiri dengan prototype. Tujuan yang ingin dicapai pada penelitian ini adalah menghasilkan coffee table berbahan bonggol jagung. Pada akhir proses dihasilkan prototype produk coffee table dengan material bonggol jagung dan menawarkan nilai kebaruan berupa penerapan material bonggol jagung pada produk coffee table.
Dietary experiences during fixed orthodontic treatment
Authors: En Priscilla Lee Xie , SoYeon O. , Nor Najwa Nawarah Mohamad , Mei Li , Farella Mauro , Prasad Sabarinath 
Published: January 2023

Objectives:
Orthodontists generally recommend avoidance of certain foods during fixed appliance (FA) treatment, based on anecdotal information. This study aimed to identify the dietary preferences and experiences of patients undergoing FA treatment as a step toward the preparation of evidence-based dietary guidelines.

Material and Methods:
Questionnaires regarding dietary preferences and experiences of patients undergoing FA treatment were applied to a convenience sample of 38 adolescents (12 M; 26 F). Open-ended responses were summarized and visualized in a world cloud generator. 5-point Likert and Visual Analog Scales (VAS) were used to record the closed-ended responses. Descriptive statistics and multivariate analysis of variance were used to analyze questionnaire findings.

Results:
Lollies, apples, and nuts frequently caused problems with FA. The most frequent reason for avoiding certain types of food was worry about appliance breakage, followed by pain and sensitivity. VAS scores indicated that toffee and caramel scored highest (65.1% F and 54.1% M) for discomfort followed by corn on the cob (64.4% F and 48.7% M) and apples (56.6% F and 55.3% M). VAS scores did not differ significantly between the sexes (P > 0.05). Nearly, a quarter of the sample reported that FA negatively affected their eating behaviors, causing pain and discomfort during eating. No sex differences (P > 0.05) were found for negative experiences with food.

Conclusion:
Dietary preferences and experiences of patients undergoing FA treatment were identified concerning a New Zealand diet profile. A future study with a larger sample size will help formulate evidence-based dietary guidelines during FA treatment.
Pembelajaran Ilmu Pengetahuan Alam (IPA) Dengan Menganalisis Kesulitan Siswa Dalam Di Masa Pandemi
Authors: Mardhotillah  , Novallyan Devie , Putra Darma 
Published: January 2023

Berdasarkan penelitian yang telah di lakukan pada tanggal 29 Juli 2021 di temukan masih banyak kesulitan yang di hadapi para siswa apalagi di masa pandemi saat ini, Yaitu masalah kesulitan belajar. Penelitian ini bertempat di SMP 16 Kota Jambi populasi yang di gunakan pada penelitian ini ada 2 kelas , subjek penelitian adalah siswa kelas VIII D dan VIII E penelitian ini bertujuan untuk mengetahui kesulitan siswa belajar IPA pada masa pandemi covid-19 di SMP 16 kota jambi meliputi minat dan sikap sedangkan faktor eksternal meliputi lingkungan kesuarga, kesehatan dan kebiasaan belajar siswa. Teknik analisis data menggunakan angket dan wawancara dokumentasi.

Kata Kunci: Kesulitan belajar IPA
Pembelajaran Biologi dengan Mengimplementasikan Model Think Pair and Share untuk Meningkatkan Hasil Belajar Siswa
Authors: Berlia Elsa , Novallyan Devie , Gusriani Nanda 
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan hasil pembelajaran Biologi dengan menggunakan model pembelajaran Think Pair and Share (TPS) di MAN 2 Tanjung jabung Timur. Metode penelitian yang digunakan adalah metode Penelitian Tindakan Kelas (Classroom Action Research). Subjek penelitian ini adalah siswa kelas XI MAN 2 Tanjung Jabung Timur yang terdiri dari 30 siswa dan 1 guru pengampu mata pelajaran Biologi kelas XI MAN 2 Tanjung Jabung Timur. Penelitian ini menggunakan desain atau model Kurt Lewin, sedangkan pengumpulan data dilakukan dengan teknik observasi, tes, wawancara, dan dokumentasi. Hasil penelitian ini menunjukkan bahwa implementasi model Think Pair and Share (TPS) dapat meningkatkan hasil belajar siswa selama proses pembelajaran. Peningkatan hasil belajar siswa dapat dilihat dari hasil tes setiap siklusnya, hasil belajar siswa pada siklus I sebesar 53% dengan kategori rendah sedangkan hasil belajar siswa pada siklus II sebesar 86% dengan kategori tinggi. Dengan demikian hasil penelitian di MAN 2 Tanjung Jabung Timur mengalami peningkatan.
Kata Kunci : Model Think Pair and Share (TPS), Biologi, Hasil Belajar
ASESMEN PERKEMBANGAN KOGNITIF PADA ANAK USIA DINI
Authors: Vina farhatunnisa haryono Vina 
Published: January 2023

Anak usia dini merupakan masa yang mendasari kehidupan manusia selanjutnya, pada periode ini anak sudah dapat mendengar, melihat dan menirukan apa yang diliha, di dengar dan dirasakannya. Perkembangan kognitif anak usia dini ini sangat penting untuk diperhatikan dan juga didukung, dengan begitu anak dapat tumbuh dan berkembang dengan baik. penelitian ini merupakan penelitian pendekatan deskriptif kualitatif yang dilakukan di TK As-salaf Tahfidzul Qur’an Tangerang selatan. Tujuan penelitian ini adalah mengetahui perkembangan kognitif anak, mendeskripsikan hasil assesment perkembangan kognitif anak didalam TK As-salaf Tahfidzul Qur’an Tangerang selatan, penelitian ini menunjukan bahwa kegiatan dalam mengembangkan kognitif anak berupa konsep menghitung bilangan, mengelompokan, dan mengurutkan benda sesuai dengan bentuk, warna, fungsi dan ciri-cirinya. Teknik yang dilakukan yaitu wawancara kepada guru di TK As-salaf Tahfidzul Qur’an Tangerang selatan. Assesment ini mempunyai dampak yang positif dalam penerapan perkembangan kognitif, karena dapat meningkatkan aspek kognitif anak usia dini, begitu pula dengan aspek-aspek yang lainnya seperti aspek sosial emosional, bahasa, nilai agama dan moral, dan seni.
“Proletarian in Content, National in (Uni)form:” Fashion, Modernization, and National Identity in the Soviet Union
Authors: Olmsted McGraw Virginia 
Published: January 2023

Abstract
The fashion industry in the USSR developed as a socialist institution, premised on modernizing and proletarianizing a bourgeois and westward-facing system. When the All-Union House of Design (ODMO) opened in 1949, clothing designers believed that the usage of ethnic motifs based on the national costumes of the constituent republics provided the simplest means of creating clothing that reflected and celebrated the uniqueness of the USSR. Following Stalin’s death, fashion designers helped build a clothing industry that was compatible with international style trends, while endeavoring to maintain the basic tenets of Soviet design: practical, beautiful, and mass-producible clothing that reflected ethnic or national traditions. The continued utilization of ethnic and national motifs presented an image domestically and internationally of a unified, modern Soviet Union that allowed for national self-expression and beautified its citizens.
Penggunaan Media Ular Tangga pada Anak Usia 5-6 Tahun untuk Meningkatkan Keterampilan Berbicara
Authors: Jendriadi Jendriadi , Melati Rima Rahayu , Sukandar Warlan , Ismira Ismira , Puspita Vivi , Zaturrahmi Zaturrahmi , Anwar Rahmi , Desmariani Evi 
Published: January 2023

Latar belakang penelitian ini berawal dari jarangnya guru menggunakan media dalam bentuk permainan sebagai alat bantu pembelajaran, apalagi media berbentuk permainan ular tangga pada proses pembelajaran. Penelitian ini memiliki tujuan dalam rangka pengembangan media pembelajaran tematik terpadu menggunakan media ular tangga untuk anak usia 5-6 tahun. Jenis penelitian ini adalah Research and Development ( R D) menggunakan teori Sugiyono (20013). Satu tahap terakhir yang tidak penulis lakukan yaitu tahap penyebaran (dessemination) dikarenakan pandemi COVID-19 yang masih mewabah ketika penelitian dilakukan. Berdasarkan validasi yang telah dilakukan menunjukkan bahwa pengembangan media ular tangga sudah valid dan dapat digunakan dalam proses pembelajaran. Aktivitas bermain ular tangga dapat membantu anak dalam meningkatkan keterampilan berbicara karena dilaksanakan dalam bentuk bermain
Deskripsi Status Gizi Balita, Serta Partisipasi Orang Tua pada Masa Pandemi Covid-19
Authors: Wondal Rosita , Mahmud Nurhamsa , Purba Natalina , Budiarti Erna , Arfa Umikalsum , Oktaviani Winda 
Published: January 2023

Status gizi dapat menggambarkan status kesehatan dari seseorang yang dihasilkan oleh keseimbangan antara pemasukan zat gizi dan kebutuhan tubuh terkait dengan zat gizi tertentu. Penelitian ini bertujuan untuk mendeskripsikan status gizi Balita pada masa pandemi covid-19 di Kota Ternate, serta partisipasi orang tua dalam kesehatan dan gizi anak. Tipe penelitian deskriptif kuantitatif dengan metode survey pada 3 titik kecamatan di Kota Ternate yakni Ternate Barat, Tengah dan Selatan, dengan sampel Balita yang berjumlah 2798. Analisis data dengan bantuan aplikasi pencatatan dan pelaporan gizi berbasis masyarakat (e-PPGBM), wawancara serta dokumentasi. Hasil penelitian menunjukan bahwa: 1) Rata-rata status gizi Balita pada masa pandemi covid-19 di kota Ternate masih tergolong berada pada status normal, dengan 884 Balita. Yang mengalami gizi buruk sebesar 4 Balita, gizi kurang 12 Balita, Resiko gizi lebih 21 Balita, gizi lebih 6 Balita dan Obesitas sebanyak 4 Balita, dan 2) Masih belum adanya kesadaran Sebagian Orang tua dalam berpartisipasi untuk membawa anak di puskesmas atau posyandu setempat. Oleh sebab itu diperlukan edukasi pada orangtua agar mewujudkan keluarga yang sadar gizi.
Imaging and clinicopathological characteristics of breast cancer among women under the age of 40 years
Authors: Mustafa Abdullateef A. , Hasan Nada A.S. , Khalel Enam A. 
Published: January 2023

Background: although breast cancer in young women is less common and often overlooked, it is still considered a major health concern.Objectives: to evaluate the demographic, clinical, radiological and histopathological characteristics of breast cancer among a sample of Iraqi women diagnosed under the age of 40 years.Patients and methods: a retrospective study enrolled 73 females below the age of 40 years with a history of breast cancer. All data was extracted from an established information system database designed by the Principal Investigator of the Iraqi National Breast Cancer Research Project under supervision of the International Agency for Research on Cancer (IARC) over a 4-years period from 2011 to 2014.Results: seventy three women under the age of 40 years with breast cancer were included in the study out of 625 diagnosed cases at different ages (11.68%). The age at presentation ranged from 25 to 39 years, the peak age frequency (63%) was recorded in the period between 35-39 years (n=46). Family history of breast cancer was noticed in approximately 31.5% of cases (n=23). Early menarche (less than 12 years old) was detected in 78.1% (n=57) of cases. On examination, 90.4% (n=66) of patients had painless palpable breast lump. By Sonography, the lesions were spiculated margins in 52% (n=38) of patients and echogenic halo around the mass was detected in 57.5% (n=42) of cases. Stage-II disease was recognized in 54.8%(n=40) of sample of the study and majority of the tumor (98.6%) were ductal in origin. According to Scarf- Bloom-Richardson method, 60.3% (n=44) of the tumors were moderately differentiated (i.e. grade- II). Eight patients (10.9%) were presented with triple receptor-negative breast cancer and recurrence of tumor was encountered in 17.8% (n=13) of cases.Conclusions: The current study suggest that breast cancer among young Iraqi women under 40 years had high incidence rate but might be less aggressive than what is reported in western countries despite of high recurrence rate.
Associations Between Insulin-Like Growth Factor-1 and Resting-State Functional Connectivity in Cognitively Unimpaired Midlife Adults
Authors: Li Tianqi , Pappas Colleen , Klinedinst Brandon , Pollpeter Amy , Larsen Brittany , Hoth Nathan , Anton Faith , Wang Qian , Willette Auriel A. 
Published: January 2023

Background: Insulin-like growth factor (IGF)-1 plays an important role in Alzheimer’s disease (AD) pathogenesis and increases disease risk. However, prior research examining IGF-1 levels and brain neural network activity is mixed. Objective: The present study investigated the relationship between IGF-1 levels and 21 neural networks, as measured by functional magnetic resonance imaging (fMRI) in 13,235 UK Biobank participants. Methods: Linear mixed models were used to regress IGF-1 against the intrinsic functional connectivity (i.e., degree of network activity) for each neural network. Interactions between IGF-1 and AD risk factors such as Apolipoprotein E4 ( APOE4) genotype, sex, AD family history, and age were also tested. Results: Higher IGF-1 was associated with more network activity in the right Executive Function neural network. IGF-1 interactions with APOE4 or sex implicated motor, primary/extrastriate visual, and executive function related neural networks. Neural network activity trends with increasing IGF-1 were different in different age groups. Higher IGF-1 levels relate to much more network activity in the Sensorimotor Network and Cerebellum Network in early-life participants (40–52 years old), compared with mid-life (52–59 years old) and late-life (59–70 years old) participants. Conclusion: These findings suggest that sex and APOE4 genotype may modify the relationship between IGF-1 and brain network activities related to visual, motor, and cognitive processing. Additionally, IGF-1 may have an age-dependent effect on neural network connectivity.
Performance evaluation and comparative analysis of CrowWhale-energy and trust aware multicast routing algorithm
Authors: Shende Dipali K. , Angal Yogesh S. 
Published: January 2023

Multipath routing helps to establish various quality of service parameters, which is significant in helping multimedia broadcasting in the Internet of Things (IoT). Traditional multicast routing in IoT mainly concentrates on ad hoc sensor networking environments, which are not approachable and vigorous enough for assisting multimedia applications in an IoT environment. For resolving the challenging issues of multicast routing in IoT, CrowWhale-energy and trust-aware multicast routing (CrowWhale-ETR) have been devised. In this research, the routing performance of CrowWhale-ETR is analyzed by comparing it with optimization-based routing, routing protocols, and objective functions. Here, the optimization-based algorithm, namely the Spider Monkey Optimization algorithm (SMO), Whale Optimization Algorithm (WOA), Dolphin Echolocation Optimization (DEO) algorithm, Water Wave Optimization (WWO) algorithm, Crow Search Algorithm (CSA), and, routing protocols, like Ad hoc On-Demand Distance Vector (AODV), CTrust-RPL, Energy-Harvesting-Aware Routing Algorithm (EHARA), light-weight trust-based Quality of Service (QoS) routing, and Energy-awareness Load Balancing-Faster Local Repair (ELB-FLR) and the objective functions, such as energy, distance, delay, trust, link lifetime (LLT) and EDDTL (all objectives) are utilized for comparing the performance of CrowWhale-ETR. In addition, the performance of CrowWhale-ETR is analyzed in terms of delay, detection rate, energy, Packet Delivery Ratio (PDR), and throughput, and it achieved better values of 0.539 s, 0.628, 78.42%, 0.871, and 0.759 using EDDTL as fitness.