bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of AFM11 in the treatment of patients with B-cell malignancies: findings from two phase 1 studies
Authors: Topp Max , Dlugosz-Danecka Monika , Skotnicki Aleksander B. , Salogub Galina , Viardot Andreas , Klein Andreas K. , Hess Georg , Michel Christian S. , Grosicki Sebastian , Gural Alex , Schwarz Sylvia E. , Pietzko Kerstin , Gärtner Ulrike , Strassz András , Alland Leila , Mayer Jiri 
Published: January 2023

Abstract
Background
The prognosis for patients with relapsed and/or refractory (R/R) non-Hodgkin’s lymphoma (NHL) or acute lymphoblastic leukaemia (ALL) remains poor, with existing treatments having significant side effects. Developed for the treatment of these cancers, AFM11 is a tetravalent, bispecific humanised recombinant antibody construct (TandAb®) designed to bind to human CD19 and CD3 and lead to the activation of T cells inducing apoptosis and killing of malignant B cells.

Methods
Two open-label, multicentre, dose-escalation phase 1 studies evaluated the safety, pharmacokinetics and activity of AFM11 in patients with R/R CD19-positive B cell NHL (AFM11-101) and in patients with CD19 + B-precursor Philadelphia-chromosome negative ALL (AFM11-102). Adverse events (AEs) were assessed and recorded; imaging (NHL) or bone marrow assessment (ALL) were used to evaluate response. Additional pharmacodynamic assays undertaken included cytokine release analysis and B-cell and T-cell depletion.

Results
In AFM11-101, 16 patients with R/R NHL received AFM11 in five different dose cohorts. Of which, 14 experienced drug-related treatment-emergent AEs (TEAEs) [including five serious AEs (SAEs)], five patients experienced dose-limiting toxicity (DLT) and ten patients discontinued the study. The high number of neurological events led to a decrease in infusion frequency during the study. No objective response to treatment was observed. In AFM11-102, 17 patients with R/R ALL received AFM11 in six different dose cohorts. Thirteen patients experienced drug-related TEAEs (including four SAEs), DLTs occurred in two patients and five patients discontinued the study. An objective response was recorded in three patients. The maximum tolerated dose could not be determined in either study due to early termination.

Conclusions
AFM11 treatment was associated with frequent neurological adverse reactions that were severe in some patients. In ALL, some signs of activity, albeit short-lived, were observed whereas no activity was observed in patients with NHL; therefore, further clinical development was terminated.

Trial registration
NCT02106091. Safety Study to Assess AFM11 in Patients With Relapsed and/or Refractory CD19 Positive B-cell NHL. Registered April 2014. NCT02848911. Safety Study to Assess AFM11 in Patients With Relapsed or Refractory Adult B-precursor ALL. Registered July 2016.
A systematic review of interventions in the early course of bipolar disorder I or II: a report of the International Society for Bipolar Disorders Taskforce on early intervention
Authors: Ratheesh A. , Hett D. , Ramain J. , Wong E. , Berk L. , Conus P. , Fristad M. A. , Goldstein T. , Hillegers M. , Jauhar S. , Kessing L. V. , Miklowitz D. J. , Murray G. , Scott J. , Tohen M. , Yatham L. N. , Young A. H. , Berk M. , Marwaha S. 
Published: January 2023

Abstract
Background
Given the likelihood of progressive illness in bipolar disorder (BD), it is important to understand the benefits and risks of interventions administered early in illness course. We conducted a systematic review of the effectiveness of interventions in the early course of BD I or II.

Methods
We completed a systematic search on MEDLINE, PsycINFO, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL and Google Scholar from 1/1/1979 till 14/9/2022. We included controlled trials examining intervention effects on symptomatic, course, functional and tolerability outcomes of patients in the ‘early course’ of BD I or II. We classified patients to be in early course if they (a) were seeking help for the first time for a manic episode, (b) had a lifetime history of up to 3 manic episodes, or (c) had up to 6 lifetime mood episodes. Evidence quality was assessed using the GRADE approach.

Results
From 4135 unique publications we included 25 reports representing 2212 participants in 16 randomized studies, and 17,714 participants from nine non-randomized studies. Available evidence suggested that in early illness course, lithium use was associated with lower recurrence risk compared with other mood stabilizers. Mood stabilizers were also associated with better global functioning, compared with the use of antipsychotics in the medium term. While summative findings regarding psychological therapies were limited by heterogeneity, family-focused and cognitive-behavioral interventions were associated with reduced recurrence risk or improved symptomatic outcomes. There was some evidence that the same pharmacological interventions were more efficacious in preventing recurrences when utilized in earlier rather than later illness course.

Conclusions and recommendations
While there are promising initial findings, there is a need for more adequately powered trials to examine the efficacy and tolerability of interventions in youth and adults in early illness course. Specifically, there is a compelling need to compare the relative benefits of lithium with other pharmacological agents in preventing recurrences. In addition to symptomatic outcomes, there should be a greater focus on functional impact and tolerability. Effective pharmacological and psychological interventions should be offered to those in early course of BD, balancing potential risks using shared decision-making approaches.
Interventions to improve the implementation of evidence-based healthcare in prisons: a scoping review
Authors: Blackaby Jenna , Byrne Jordan , Bellass Sue , Canvin Krysia , Foy Robbie 
Published: January 2023

Abstract
Background
There are challenges to delivering high quality primary care within prison settings and well-recognised gaps between evidence and practice. There is a growing body of literature evaluating interventions to implement evidence-based practice in the general population, yet the extent and rigour of such evaluations in incarcerated populations are unknown. We therefore conducted a scoping literature review to identify and describe evaluations of implementation interventions in the prison setting.

Methods
We searched EMBASE, MEDLINE, CINAHL Plus, Scopus, and grey literature up to August 2021, supplemented by hand searching. Search terms included prisons, evidence-based practice, and implementation science with relevant synonyms. Two reviewers independently selected studies for inclusion. Data extraction included study populations, study design, outcomes, and author conclusions. We took a narrative approach to data synthesis. We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance for scoping reviews.

Results
Fifteen studies reported in 17 papers comprised one randomised controlled trial, one controlled interrupted time series analysis and 13 uncontrolled before and after studies. Eight studies took place in the US and four in the UK. Ten studies evaluated combined (multifaceted) interventions, typically including education for staff or patients. Interventions most commonly targeted communicable diseases, mental health and screening uptake. Thirteen studies reported adherence to processes of care, mainly testing, prescribing and referrals. Fourteen studies concluded that interventions had positive impacts.

Conclusions
There is a paucity of high-quality evidence to inform strategies to implement evidence-based health care in prisons, and an over-reliance on weak evaluation designs which may over-estimate effectiveness. Whilst most evaluations have focused on recognised priorities for the incarcerated population, relatively little attention has been paid to long-term conditions core to primary care delivery. Initiatives to close the gaps between evidence and practice in prison primary care need a stronger evidence base.
CRNet: a multimodal deep convolutional neural network for customer revisit prediction
Authors: Park Eunil 
Published: January 2023

AbstractSince mobile food delivery services have become one of the essential issues for the restaurant industry, predicting customer revisits is highlighted as one of the significant academic and research topics. Considering that the use of multimodal datasets has gained notable attention from several scholars to address multiple industrial issues in our society, we introduce CRNet, a multimodal deep convolutional neural network for predicting customer revisits. We evaluated our approach using two datasets [a customer repurchase dataset (CRD) and mobile food delivery revisit dataset (MFDRD)] and two state-of-the-art multimodal deep learning models. The results showed that CRNet obtained accuracies and Fi-Scores of 0.9575 (CRD) and 0.9436 (MFDRD) and 0.9730 (CRD) and 0.9509 (MFDRD), respectively, thus achieving higher performance levels than current state-of-the-art multimodal frameworks (accuracy: 0.7417–0.9012; F1-Score: 0.7461–0.9378). Future research should aim to address other resources that can enhance the proposed framework (e.g., metadata information).
Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis
Authors: Zangouei Amir Sadra , Zangoue Malihe , Taghehchian Negin , Zangooie Alireza , Rahimi Hamid Reza , Saburi Ehsan , Alavi Mahya Sadat , Moghbeli Meysam 
Published: January 2023

AbstractCell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor cells. Since, early diagnosis has pivotal role in better cancer management and treatment, it is required to introduce the non-invasive diagnostic markers. Long non-coding RNAs (LncRNAs) have higher stability in body fluids in comparison with mRNAs. Therefore, they can be used as efficient non-invasive markers for the early detection of breast cancer (BCa). In the present review we have summarized all of the reported lncRNAs involved in cell cycle regulation in BCa. It has been reported that lncRNAs mainly affect the cell cycle in G1/S transition through the CCND1/CDK4-6 complex. Present review paves the way of introducing the cell cycle related lncRNAs as efficient markers for the early detection of BCa.
Evaluation of the contour of edentulous jaw sections in the transversal plane and the buccolingual vertical-level disparity in CBCT and panoramic radiography images: a retrospective comparative study
Authors: Ketabi Ali Reza , Piwowarczyk Andree , Schulz Matthias Christian , Lauer Hans-Christoph , Hassfeld Stefan 
Published: January 2023

Abstract
Purpose
This study investigates whether edentulous jaw sections in the planned implant position exhibit jaw contours funnel-shaped or exhibit pronounced retraction of the jaw (unusual jaw contours) in the transversal plane of the three-dimensional (3D) images, not visible in two-dimensional (2D) images.

Methods
A total of 335 patients with an edentulous section of the jaw that required dental implants were selected. Anonymised radiologic patients’ data were collected, comprising cone-beam computed tomography (CBCT) images of the edentulous jaw sections. In the first stage, unusual jaw contours were examined, including funnel-shaped or pronounced retraction of the jaw and hypodense regions with an undercut and/or bone deficit. In the second stage, the variation in the height of the alveolar ridge between the lingual and buccal contour in the edentulous jaw sections was assessed.

Results
The CBCT images of an unusual jaw contour were observed in 8 cases (2.4%) in the maxilla on the left and 10 cases (3%) in the maxilla on the right. In the mandible, a jaw contour deviates in 39 cases (12.1%) on the left side and 39 cases (12.1%) on the right side. A height difference was detected in the upper jaw in 307 cases and the lower jaw in 265 cases. The discrepancy was 2.09 mm (± 2.25 mm) in the maxilla and 3.97 mm (± 3.45 mm) in the mandible.

Conclusions
The CBCT scan provides useful information to avoid complications in the preoperative planning phase and surgical planning in implant dentistry.

Graphical Abstract
Introduction of a PRRSV-1 strain of increased virulence in a pig production structure in Spain: virus evolution and impact on production
Authors: Martín-Valls Gerard E. , Cortey Martí , Allepuz Alberto , Illas Francesc , Tello Montserrat , Mateu Enric 
Published: January 2023

AbstractBackgroundA strainof Porcine reproductive and respiratory syndrome virus(PRRSV), showing characteristics of enhanced virulence, affected a pyramidal production system from Spain with 7600 sows in 4 genetic nuclei and 13,000 sows in multipliers. Different PRRSV strains circulating in this production system from December 2020 to October 2021 were detected and sequenced. The spread of each isolate was examined and their impact on health and production in three of the affected farms was evaluated.ResultsThe newly emerged PRRSV isolate with enhanced virulence entered the system before the onset of the study (January 2020) and afterwards four significantly different clades were detected during the study period in different farms, probably because of independent introduction events. The diversification of the enhanced virulence strain was higher for those clades (substitution rates up to 1.1% nucleotides/year) compared to other PRRSV strains present in the production system (up to 0.17%), suggesting a faster spread and adaptation. The impact of the infection in the first affected farm was dramatic, with an average abortion rate above 27% during 17 weeks before returning to the baseline production. Fertile sow mortality reached 6.5% for 39 weeks. In two farms infected later by other clades of this enhanced virulence strain, the impact was less acute; despite the fact that for parameters such as the proportion of stillbirths or mummies, more than 10 months were needed to recover pre-outbreak values. In the examined nurseries, mortalities reached peaks between 28 and 50% and several months were needed to return to normality.ConclusionIntroduction of a PRRSV strain of enhanced virulence in a production system where several farms were previously positive for other PRRSV strains, resulted in a fast spread such as would be observed in naïve farms. The productive and health impact was very high taking several months to return to normality.
“It is all her fault”: psychosocial correlates of the negative attitudes towards rape victims among the general population of Pakistan
Authors: Kazmi Syed Messum Ali , Iftikhar Rabia , Fayyaz Muhammad Umar 
Published: January 2023

Abstract
Background
Rape myths are marked for being false beliefs about sexual assault. With the problem being quite prevalent around the world, research has shown that numerous factors such as rape proclivity and perpetuation of rape myths are critical. The present study assesses the role of rape myths acceptance, rape victim empathy, and causal attributions towards rape victims as significantly predicting attitudes towards rape victims among the general population of Pakistan. Rape myths acceptance and causal attributions would significantly and positively predict negative attitudes towards rape victims.

Method
A cross-sectional research design was used for the study. The online survey questionnaire was filled by 573 participants including 275 males and 298 females who were selected through purposive sampling from the general population of Pakistan. The sample size was estimated using G*Power analysis with 95% confidence intervals. Data collection was done using Illinois rape myths, attitudes towards rape victim’s scale, rape victim empathy, and causal attributions scale were used. Data analysis was done using Pearson product-moment correlation, hierarchical regression, MANOVA, and mediation analysis via AMOS, all of which were executed using SPSS 21.0.

Results
The findings showed that higher levels of rape myths acceptance, low empathy towards rape victims, and victim blaming are significantly associated with negative attitudes towards rape victims. There were no gender differences among the participants. However, rape victim empathy significantly mediated the association between rape myths acceptance and rape victim empathy. It was also found that rape myths acceptance, rape victim empathy, and causal attributions significantly predicted attitudes towards rape victims. Another core finding was that there were no gender differences among participants with regard to rape myths acceptance, rape victim empathy, causal attributions, and attitudes towards rape victims.

Conclusions
Therefore, the findings contribute towards a better understanding of the rape myths in the general population of Pakistan and how the prevalence of such myths may contribute towards social, cultural, and legal problems of rape myths. The study also provides policy implications for a region where rape victims experience higher levels of blame and limited legal backing and support.
Probiotic lactic acid bacteria as a means of preventing in vitro urinary catheter colonization and biofilm formation
Authors: Mahgoub Mohamed Anwar , Abbass Aleya Abdel Gawad , Abaza Amani Farouk , Shoukry Mohamed Shafik 
Published: January 2023

Abstract
Background
Catheter-associated urinary tract infections (CAUTIs) are the most common infections found in healthcare facilities. Urinary catheters predispose the development of CAUTIs by destroying natural barriers and providing a source for infection and biofilm formation (BF). This study aimed to evaluate probiotic lactic acid bacteria (LAB) as a means of preventing in vitro urinary catheter colonization and BF.

Methods
Cross-sectional screening, followed by an experimental study, was conducted on 120 catheterized patients admitted to the urology department in a tertiary care hospital for 7 months. The isolated and identified uropathogens were tested for their antimicrobial susceptibility patterns by the disk diffusion method according to Clinical and Laboratory Standards Institute recommendations and examined for their ability to produce biofilms using a microtiter plate (MtP) assay. Five LAB (Lactobacillus acidophilus (L. acidophilus), Bifidobacterium bifidum (B. bifidum), L. paracasei, L. pentosus, and L. plantarum) were identified and examined for preventing in vitro colonization and BF of some isolated uropathogens on Foley urinary catheter surfaces.

Results
Of the 120 samples collected, 32.5% were found to be associated with CAUTIs. Of isolated organisms, 74.4% were gram-negative bacilli, while gram-positive cocci represented 14%, and only 11.6% were of the Candida species. About two-thirds of isolated uropathogens were biofilm formers. All five probiotic strains had inhibitory effects on the growth of all the uropathogens tested but with varying intensities according to the duration of application after 2, 4, and 6 days.

Conclusions
The prevalence of CAUTIs was high, and the predominant bacterial isolates were gram-negative bacilli. Many of the studied uropathogens were biofilm formers. The bacterial isolates had a higher prevalence of resistance to commonly prescribed antimicrobial agents. Probiotics have the potential to prevent in vitro urinary catheter colonization and inhibit BF. Pre-coating urinary catheters with probiotics is recommended after ensuring the safety of probiotics’ use in vivo by carrying out further large-scale studies.
Untangling the complex interactions between turtle ants and their microbial partners
Authors: Ramalho Manuela O. , Moreau Corrie S. 
Published: January 2023

AbstractBackgroundTo understand the patterns of biodiversity it is important to consider symbiotic interactions as they can shape animal evolution. In several ant genera symbiotic interactions with microbial communities have been shown to have profound impacts for the host. For example, we know that for Camponotini the gut community can upgrade the host’s diet and is shaped by development and colony interactions. However, what is true for one ant group may not be true for another. For the microbial communities that have been examined across ants we see variation in the diversity, host factors that structure these communities, and the function these microbes provide for the host. In the herbivorous turtle ants (Cephalotes) their stable symbiotic interactions with gut bacteria have persisted for 50 million years with the gut bacteria synthesizing essential amino acids that are used by the host. Although we know the function for some of these turtle ant-associated bacteria there are still many open questions.ResultsIn the present study we examined microbial community diversity (16S rRNA and 18S rRNA amplicons) of more than 75 species of turtle ants across different geographic locations and in the context of the host’s phylogenetic history. Our results show (1) that belonging to a certain species and biogeographic regions are relevant to structuring the microbial community of turtle ants; (2) both bacterial and eukaryotic communities demonstrated correlations and cooccurrence within the ant host; (3) within the core bacterial community, Burkholderiaceae bacterial lineage were the only group that showed strong patterns of codiversification with the host, which is remarkable since the core bacterial community is stable and persistent.ConclusionsWe concluded that for the turtle ants there is a diverse and evolutionarily stable core bacterial community, which leads to interesting questions about what microbial or host factors influence when these partner histories become evolutionarily intertwined.
Incidence and risk factors for surgical site infection (SSI) after primary hip hemiarthroplasty: an analysis of the ACS-NSQIP hip fracture procedure targeted database
Authors: Gupta Arjun , Shin John , Oliver Dylan , Vives Michael , Lin Sheldon 
Published: January 2023

Abstract
Introduction
Primary hip hemiarthroplasty (HHA) is frequently utilized to treat geriatric hip fractures, which are associated with significantly higher morbidity and mortality. While not particularly common, surgical site infection (SSI) is a major complication that frequently requires revision surgery in a frail population. The objective of this study was to determine the incidence of and risk factors for SSI after HHA in hip fracture patients.

Materials and methods
This retrospective cohort study was performed using the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database. Geriatric patients (65+) who underwent HHA for non-pathologic, traumatic hip fractures between 2016–2017 were included. Demographic variables, comorbidities, operative variables, and complications were compared between "SSI" and "non-SSI" groups. Multivariate regression identified independent risk factors for postoperative SSI. Significance was set at P = 0.05.

Results
A total of 6169 patients were included. The overall incidence of SSI was 1.3%. SSI was significantly associated with body mass index (BMI), preoperative functional status, congestive heart failure, chronic corticosteroid use, intraoperative time, sepsis, wound dehiscence, readmission within 30-days, and reoperation. On multivariate analysis, chronic steroid use (OR: 2.30, 95% CI: 1.13–4.70), BMI ≥ 35 kg/m2 (OR: 3.59, 95% CI: 1.57–8.18), and intraoperative time ≥120 mins (OR: 2.15, 95% CI: 1.08–4.27) were found to be independent risk factors.

Conclusions
Postoperative SSI is a serious complication that is responsible for prolonged hospital stays, increased mortality, and greater healthcare costs. Here, we identified multiple risk factors for SSI after primary HHA in the US elderly population.