bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ways to increase the productivity of L-PBF processes
Authors: Kasprowicz Marcin , Pawlak Andrzej , Jurkowski Paweł , Kurzynowski Tomasz 
Published: July 2023

Abstract
One of the main limitations of additive manufacturing (AM) technologies consists in the relatively low build rate. Low productivity discourages companies from investing in AM machines, thus limiting the market of additive technologies. Machine manufacturers have introduced new solutions to their designs to increase the build rate, some of them are described in this paper. However, design improvements are not the only method to accelerate the process. The paper specifies factors that influence the build rate in the laser powder bed fusion process and provides an analytical assessment and comparison of the significance of how they affect its productivity. The influence that a change in selected parameters has on the process and the influence of multi-laser systems on its productivity are analysed in terms of the melted material quality. The processes from which the data for analysis were obtained were carried out on an SLM 280 machine with single- and dual-laser versions as well as on an SLM 500 with four lasers. Two types of samples, solid and thin-walled, both of the same volume, were tested. The data under analysis were the process times for both geometries, manufactured with different sets of parameters from the adopted range. Processing times were analysed to determine the main effects and interaction effects for extreme values of a given parameter. The height of the melted powder layer had the greatest influence on the build rate, which turned out to be greater even than the application of a two-laser system.
Family and Christian Ethics
Authors: Schaafsma Petruschka 
Published: July 2023

In this book, Petruschka Schaafsma offers an innovative appraisal of family. Eschewing the framework of worry and renewal that currently dominates family studies, she instead explores the topic through the concepts of 'givenness' and 'dependence'. 'Givenness' highlights the fact that family is not chosen; 'dependence' refers to being intimately included in each other's identities and lives. Both experiences are challenging, especially in a contemporary context, where independence and freedom to shape one's own life have become accepted ideals. Schaafsma shows the impasses to which these ideals lead in several disciplines – theology, philosophy, sociology, social anthropology and care ethics. She moves constructively beyond them by tapping literary, artistic and biblical sources for their insights on family. Grounded in a theological approach to family as 'mystery' rather than 'problem', she develops an understanding of the current controversial character of family that accounts for both its ordinary and transcendent character. This title is available as Open Access on Cambridge Core.
Politics by other means: an analysis of the discourses of Italian technocratic Prime Ministers
Authors: Giannone Diego , Cozzolino Adriano 
Published: July 2023

AbstractTechnocracy is becoming increasingly relevant in Western democracies and particularly in Italy, a country characterised by four technocratic governments in three decades. Despite the growing number of dedicated studies, there is a persistent gap in the existing literature concerning the discursive dimension of technocracy – namely, how technocrats frame the historical context, legitimise their policy agendas and, more broadly, the establishment of their governments. This study aims to fill this gap by analysing the speeches given by four Italian technocratic Prime Ministers to the parliament when asking for the vote of confidence. Methodologically, we perform first the content analysis to map the themes addressed in the speeches, their quantitative relevance and variation over time. Then, we turn to critical discourse analysis to understand the specific argumentative strategies that legitimise policy action in five key and interrelated dimensions: context, legitimation, the state, European Union and political economy. The analysis seeks to answer three research questions: What are the main discursive strategies of legitimation used by technocrats? Do they change significantly between governments and over time? Do partisan policy options and worldviews emerge clearly, or do they remain under the surface? The paper aims to contribute to the theoretical conceptualisation and empirical analysis of technocracy by highlighting the subjective, performative and overall political dimensions of the phenomenon.
CENTENNIAL TO MILLENNIAL-SCALE FLUCTUATIONS OF THE LAKE SUIGETSU ATMOSPHERIC 14C RECORD REPRESENT AUTHENTIC 14C FEATURES OVER LAST GLACIAL-TO-DEGLACIAL TIMES
Authors: Sarnthein Michael , Grootes Pieter M , Mudelsee Manfred 
Published: July 2023

ABSTRACTShort-term fluctuations in atmospheric radiocarbon (14C) concentration mark the tree-ring record for the last ∼15 kyr. Terrestrial macrofossils from sediment cores of Lake Suigetsu, Japan, extend this record of fluctuations back to >35 cal ka BP. Their significance, however, is under debate since the signal-to-noise ratio of the Suigetsu record is low and progressively decreases with increasing age. Coherent semi-millennial-scale structures of the Suigetsu 14C record have nevertheless been identified by three different techniques, namely visual inspection, analyses of the first derivative of 14C vs. calendar age, and Bayesian spline inflections of 14C concentration vs. calendar age, and hence appear objectively real. These 14C fluctuations correlate closely with those of the tree-ring-based 14C master record ∼10–14 cal ka. Thus, Suigetsu fine structures attain global significance and may properly reflect atmospheric 14C variability back to ∼35 cal ka. Carbonate-based 14C records from speleothems and ocean sediments are far smoother and form, together with Suigetsu and other data, the backbone of the IntCal20 record >14 cal ka that largely lacks the Suigetsu fine structure. 14C decay reduces 14C-signal amplitudes over time, so Holocene-style 14C signals of solar modulation disappear in the noise beyond ∼10 cal ka. The remaining older 14C fine structures had larger forcings, most likely linked to climate and carbon cycle, especially ocean-atmosphere CO2 exchange, and thus contain valuable information about these factors. They may also provide global stratigraphic tie points to correlate 14C records of oceanic plankton sediments and climate signals independent of problems with local 14C reservoir effects.
EXTENSIVE SURVEY ON RADIOCARBON DATING OF ORGANIC INCLUSIONS IN MEDIEVAL MORTARS IN THE CZECH REPUBLIC
Authors: Pachnerová Brabcová Kateřina , Kundrát Pavel , Krofta Tomáš , Suchý Václav , Petrová Markéta , John David , Kozlovcev Petr , Kotková Kristýna , Fialová Anna , Kubančák Ján , Válek Jan , Svetlik Ivo 
Published: July 2023

ABSTRACTDating organic inclusions in mortars such as charcoals is a useful alternative or complementary method to dating mortars themselves, helping to estimate the building age. To assess the limitations of this dating approach, organic inclusions were searched for in surface mortar layers of six early to late medieval buildings in the Czech Republic with relatively well-known age. Altogether, 123 samples were found. About 80% were successfully radiocarbon (14C) dated. However, only 66% originated from wood relatively young when used in lime burning. To judge which samples are relevant to the actual building date, sufficient statistics is crucial. We recommend dating at least 5–10 samples, i.e., collecting 6–12 samples, for a site with uncomplicated building history, or per building phase. Otherwise, unrealistically old or young dates might be obtained. With the recommended statistics, inclusion-based dating provides building ages with uncertainty of 50–100 years.
A robust control scheme for a 2

P

US+RR parallel robot for ankle rehabilitation
Authors: Flores-Salazar Erick D. , Lugo-González Esther , Arias-Montiel Manuel , Gallardo-Alvarado Jaime 
Published: July 2023

AbstractThis paper presents a robust adaptive controller based on the backstepping technique using an extended state observer (ESO), implemented on a 2PUS+RR parallel robot, to minimize the trajectory tracking error. The proposed backstepping-ESO controller scheme is designed to compensate for the robot’s structured (parametric) and unstructured (nonlinear friction, external disturbances, and dynamics) uncertainties. The overall stability of the controller is guaranteed by the Lyapunov theory. Cosimulation in MATLAB-Simulink and ADAMS View is presented to validate the results of the ESO and backstepping controller implemented in the virtual and physical prototype. For the virtual prototype, it was determined that the system is stable in 2 s and presents a maximum absolute error of 3.5 ×
$10^{-6}$
m for the actuator position and 2.8 ×
$10^{-5}$
rad for mobile platform orientation. Regarding the physical robot, a maximum absolute error of 5 ×
$10^{-4}$
m for the actuator position and 0.0575 rad for the orientation of the robot mobile platform values do not represent a problem for ankle rehabilitation movements. Experimental results were also presented and compared with ankle motion to demonstrate that the applied control system meets the motion requirements of the ankle rehabilitator.
Characterizing experiential elements of early-life stress to inform resilience: Buffering effects of controllability and predictability and the importance of their timing
Authors: Cohodes Emily M. , Sisk Lucinda M. , Keding Taylor J. , Mandell Jeffrey D. , Notti Madeline E. , Gee Dylan G. 
Published: July 2023

AbstractKey theoretical frameworks have proposed that examining the impact of exposure to specific dimensions of stress at specific developmental periods is likely to yield important insight into processes of risk and resilience. Utilizing a sample ofN= 549 young adults who provided a detailed retrospective history of their lifetime exposure to numerous dimensions of traumatic stress and ratings of their current trauma-related symptomatology via completion of an online survey, here we test whether an individual’s perception of their lifetime stress as either controllable or predictable buffered the impact of exposure on trauma-related symptomatology assessed in adulthood. Further, we tested whether this moderation effect differed when evaluated in the context of early childhood, middle childhood, adolescence, and young adulthood stress. Consistent with hypotheses, results highlight both stressor controllability and stressor predictability as buffering the impact of traumatic stress exposure on trauma-related symptomatology and suggest that the potency of this buffering effect varies across unique developmental periods. Leveraging dimensional ratings of lifetime stress exposure to probe heterogeneity in outcomes following stress – and, critically, considering interactions between dimensions of exposure and the developmental period when stress occurred – is likely to yield increased understanding of risk and resilience following traumatic stress.
Empfehlungen zur Bewertung wissenschaftlicher Leistungen bei Berufungsverfahren in der Psychologie
Authors: Gärtner Anne , Leising Daniel , Schönbrodt Felix D. 
Published: July 2023

Zusammenfassung: Traditionelle metrische Indikatoren für wissenschaftliche Produktivität (z. B. Impact-Faktoren von Zeitschriften, h-Index) werden kritisiert, weil (a) empirische Studien ihre Validität in Frage stellen und sie (b) eine Kultur zu fördern scheinen, die der reinen Quantität Vorrang gegenüber der inhaltlichen Qualität der Forschung gibt. Der Ruf nach spezifischen, besseren Alternativen zu den derzeit gängigen Leistungsindikatoren wird immer lauter. Die Deutsche Gesellschaft für Psychologie hat nach der Unterzeichnung von DORA und dem Beitritt zu CoARA eine Arbeitsgruppe mit der Frage befasst, wie eine verantwortungsvollere Form der Forschungsbewertung für die Psychologie aussehen könnte. Über den aktuellen Stand dieser Überlegungen berichten wir hier: Konkret schlagen wir ein zweistufiges Bewertungsverfahren vor, das die Objektivität und Effizienz metrischer Indikatoren (Phase 1) mit einer vertieften, diskursiven Bewertung spezifischer Forschungsinhalte verbindet (Phase 2) verbindet. Wir plädieren für eine Ausweitung des Spektrums relevanter Forschungsbeiträge und schlagen Qualitätskriterien für Forschungsartikel, Datensätze und Forschungssoftware vor, welche vor allem deren methodische Stringenz erfassen. Anhand dieser Kriterien wird in der ersten Phase des Bewertungsprozesses ermittelt, ob eine Mindestschwelle für methodische Stringenz erreicht wird, die Kandidat:innen erfüllen müssen, um für eine Einstellung oder Beförderung in Frage zu kommen. Im Gegensatz dazu sollen in der zweiten Phase des Beurteilungsprozesses Metriken keine Rolle mehr spielen, sondern die spezifischen Inhalte der Forschungsarbeiten der Kandidat:innen im Fokus einer vertieften Diskussion stehen. Wir stellen konkrete Erhebungsinstrumente bereit, die zum Teil bereits in der Praxis erprobt wurden. Unser Ziel ist es, eine breite Diskussion über das Thema anzuregen und letztlich dazu beizutragen, dass die Bedeutung der wissenschaftlichen Qualität im Rahmen von Berufungsverfahren spürbar gestärkt wird.
The Influence of Weather Patterns and the Madden‐Julian Oscillation on Extreme Precipitation Over Sri Lanka
Authors: Deoras Akshay , Turner Andrew G. , Hunt Kieran M. R. , Jayawardena I. M. Shiromani Priyanthika 
Published: July 2023

AbstractSri Lanka is affected by extreme precipitation events every year, which cause floods, landslides and tremendous economic losses. We use the ERA5 reanalysis data set to understand the association of extreme precipitation events with 30 weather patterns, which were originally derived to represent the variability of the Indian climate during January–December 1979–2016. We find that weather patterns that are most common during the northeast monsoon (December–February) and second intermonsoon (October–November) seasons produce the highest number of extreme precipitation events. Furthermore, extreme precipitation events occurring during these two seasons are more persistent than those during the southwest monsoon (May–September) and first intermonsoon (March–April) seasons. We analyze the modulation of extreme precipitation events by the Madden‐Julian Oscillation, and find that their frequency is enhanced (suppressed) in phases 1–4 (5–8) for most weather patterns.
Response of Tropical Overshooting Deep Convection to Global Warming Based on Global Cloud‐Resolving Model Simulations
Authors: Wu Xueke , Fu Qiang , Kodama Chihiro 
Published: July 2023

AbstractTropical overshooting deep convections (ODCs) play a vital role in vertical transport of boundary layer pollutants, especially short‐lived species, to upper troposphere and lower stratosphere, with important implications for stratospheric ozone and climate. We use simulations from a global cloud‐system resolving model, Nonhydrostatic Icosahedral Atmosphere Model (NICAM), to study ODC changes from historical period to the end of the 21st century. NICAM well reproduces Tropical Rainfall Measuring Mission‐satellite observed ODC spatiotemporal patterns. The future occurrences of ODCs with cloud top height above 15.5, 16.9, and 18.4 km scaled by the global temperature increase will increase by 7%/K, 27%/K, and 90%/K, respectively, over ocean where the atmosphere is becoming warmer and wetter. The corresponding changes are −1%/K, 10%/K, and 37%/K over land where the atmosphere will become hotter but drier. Relative to tropical cold point tropopause height, ODCs will only change by 3%/K, with 6%/K over the ocean but −3%/K on land.
Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
Authors: Dieberger Anna M. , Obermayer-Pietsch Barbara , Harreiter Jürgen , Desoye Gernot , van Poppel Mireille N. M. ,   DALI Core Investigator group, Simmons David , Corcoy Rosa , Perez Juan M. Adelantado , Kautzky-Willer Alexandra , Damm Peter , Mathiesen Elizabeth , Jensen Dorte M. , Andersen Lise Lotte T. , Dunne Fidelma , Lapolla Annunziata , Dalfra Maria G. , Bertolotto Alessandra , Jelsma Judith G. M. , Galjaard Sander , Wender-Ozegowska Ewa , Zawiejska Agnieszka , Hill David , Devlieger Roland , Snoek Frank J. 
Published: July 2023

Abstract
Background/Objectives
Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex.

Subjects/Methods
Participants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI  ≥ 29 kg/m2 were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered.

Results
Almost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (−0.520%; 95% CI: −1.011%, −0.031% and −4.649%; −7.876%, −1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (−0.145 µg/l; −0.279 µg/l, −0.005 µg/l). No associations were found with birthweight or other cord blood parameters.

Conclusions
Maternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.
A novel transcription factor SIPA1: identification and verification in triple-negative breast cancer
Authors: Guo Lijuan , Zhang Wanjun , Zhang Xue , Wang Jun , Nie Jiaqi , Jin Xiaomeng , Ma Ying , Wang Shi , Zhou Xinhong , Zhang Yilei , Xu Yan , Tanaka Yoshimasa , Yuan Jingping , Liao Xing-Hua , Gong Yiping , Su Li 
Published: July 2023

AbstractTranscription factors (TFs) regulate the expression of genes responsible for cell growth, differentiation, and responses to environmental factors. In this study, we demonstrated that signal-induced proliferation-associated 1 (SIPA1), known as a Rap-GTPase-activating protein, bound DNA and served as a TF. Importin β1 was found to interact with SIPA1 upon fibronectin treatment. A TGAGTCAB motif was recognized and bound by DNA-binding region (DBR) of SIPA1, which was confirmed by electrophoretic mobility shift assay. SIPA1 regulated the transcription of multiple genes responsible for signal transduction, DNA synthesis, cell adhesion, cell migration, and so on. Transcription of fibronectin 1, which is crucial for cell junction and migration of triple-negative breast cancer (TNBC) cells, was regulated by SIPA1 in a DBR-dependent manner both in vivo and in vitro. Furthermore, single-cell transcriptome sequencing analysis of specimens from a metastatic TNBC patient revealed that SIPA1 was highly expressed in metastatic TNBC. Hence, this study demonstrated that SIPA1 served as a TF, promoting TNBC migration, invasion, and metastasis.
Patient-reported understanding and dentist-reported management of periodontal diseases - a survey: do you know what gum disease is?
Authors: Rana Haajarah , Warnes Barbara , Davies Maria , West Nicola X. 
Published: July 2023

AbstractIntroduction Mild-to-moderate gingivitis is treatable by effective toothbrushing with appropriate over-the-counter oral health care products; however, rates remain high.Aim To determine patient knowledge of gingivitis and dentists' views on management.Methods Surveys were completed by dentists and dental hospital patients.Results In total, 224 patients and 50 dentists participated. Clinical health, gingivitis, or periodontitis was detected in 2%, 33% and 56% of patients, respectively; 32% reported never suffering gingival bleeding. Moreover, 74% of patients reported gingival health as very important but only 53.7% with gingivitis occasionally/often were moderately-extremely worried about their symptoms. More than 50% of patients knew gingivitis causes poor oral health but <20% knew it elevated risks of other systemic conditions. Patients thought education on risks associated with poor oral health and product recommendations were most likely, and daily reminders least likely, to improve compliance with oral health advice (OHA). Also, 40% of dentists thought their patients were relatively unaware of the importance of gingival health, 76.9% of their patient-base had gingivitis, and 96% give OHA to these patients but only 30% thought this effected improvement. The most useful tools for improving oral health were better patient knowledge of the consequences and one-to-one instruction.Conclusion Patients struggle to attain oral health following OHA. Education about gingivitis-associated risks might improve OHA compliance.
THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification
Authors: Yu Tao , Zhang Qi , Yu Shao-Kun , Nie Feng-Qi , Zhang Mei-Ling , Wang Qian , Lu Kai-Hua 
Published: July 2023

AbstractThe THO complex (THOC) is ubiquitously involved in RNA modification and various THOC proteins have been reported to regulate tumor development. However, the role of THOC3 in lung cancer remains unknown. In this study, we identified that THOC3 was highly expressed in lung squamous cell carcinoma (LUSC) and negatively associated with prognosis. THOC3 knockdown inhibited LUSC cell growth, migration, and glycolysis. THOC3 expression was regulated by TRiC proteins, such as CCT8 and CCT6A, which supported protein folding. Furthermore, THOC3 could form a complex with YBX1 to promote PFKFB4 transcription. THOC3 was responsible for exporting PFKFB4 mRNA to the cytoplasm, while YBX1 ensured the stability of PFKFB4 mRNA by recognizing m5C sites in its 3′UTR. Downregulation of PFKFB4 suppressed the biological activities of LUSC. Collectively, these findings suggest that THOC3, folded by CCT proteins can collaborate with YBX1 to maintain PFKFB4 expression and facilitate LUSC development. Therefore, THOC3 could be considered as a novel promising therapeutic target for LUSC.
A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress
Authors: Belapurkar Ratnal , Pfisterer Maximilian , Dreute Jan , Werner Sebastian , Zukunft Sven , Fleming Ingrid , Kracht Michael , SCHMITZ M. Lienhard 
Published: July 2023

AbstractThe family of hypoxia-inducible transcription factors (HIF) is activated to adapt cells to low oxygen conditions, but is also known to regulate some biological processes under normoxic conditions. Here we show that HIF-1α protein levels transiently increase during the G1 phase of the cell cycle (designated as G1-HIF) in an AMP-activated protein kinase (AMPK)-dependent manner. The transient elimination of G1-HIF by a degron system revealed its contribution to cell survival under unfavorable metabolic conditions. Indeed, G1-HIF plays a key role in the cell cycle-dependent expression of genes encoding metabolic regulators and the maintenance of mTOR activity under conditions of nutrient deprivation. Accordingly, transient elimination of G1-HIF led to a significant reduction in the concentration of key proteinogenic amino acids and carbohydrates. These data indicate that G1-HIF acts as a cell cycle-dependent surveillance factor that prevents the onset of starvation-induced apoptosis.