bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXAMINATION OF THE DIGIAGE CYBER-SENIORS PILOT STUDY FOR OLDER ADULTS FROM LOWER INCOME COMMUNITIES
Authors: Leedahl Skye , Capolino Alexandria , Brasher Melanie , Fratoni-Souza Kristin , Estus Erica 
Published: December 2022

Abstract
The University of Rhode Island (URI) team implemented a pilot program designed to bridge the digital divide between older adults and younger generations. Through this project, the goal was for older Rhode Islanders to become digitally literate by engaging them in a formal program that provides digital devices (i.e., Apple iPads), connectivity (i.e., internet connection through HotSpots), and training by supervised and trained university student mentors. This project specifically worked to promote social and economic equity by recruiting participants from lower-income communities and areas hit hardest by the COVID-19 pandemic, including those who speak English and Spanish. The final sample (N=124) for the study was primarily female (79%) and low income (82%). They were 41% Non-White and 23% Spanish speaking with 23% having a college degree or more. We conducted preliminary analysis on the first 38 participants who completed both a pre- and post-survey. Based on these analyses, the program participants have shown statistically significant improvements in frequency of tablet use (p&lt;.05), digital competency across all questions (p&lt;.05), quality of life (p&lt;.05), and social isolation (p&lt;.05). In addition, the loneliness and depression questions/variables are trending in the expected direction, so it is possible that with a more robust sample size we may see significant improvement in these areas as well. This presentation will describe the key elements of the pilot intervention and explain the findings from the full sample. The presentation will also discuss the plan for state-wide implementation of the program.
EXISTING KNOWLEDGE ASSOCIATED WITH SMART HOME HEALTH TECHNOLOGIES IN THE CARE OF OLDER PERSONS: A SYSTEMATIC REVIEW
Authors: Tian Yi Jiao (Angelina) , Felber Nadine Andrea , Pageau Félix , Schwab Delphine Roulet , Wangmo Tenzin 
Published: December 2022

Abstract
As a greater part of the global population reaches the golden age, smart home technologies are said to allow older persons to remain independent at a place of residence, or “home”, of their own choice. Though their development has been making their way to the market, there has not been a systematic review of the empirical literature on the knowledge associated with their use for persons who are 65 years or older. Hence, we conducted a systematic review of empirical peer-reviewed English, German, and French articles in ten electronic databases. Data was textually described, separated into key characteristics, logged into a customized data extraction document, and analysed using narrative synthesis. The search across ten databases revealed 144 empirical papers that were admissible to our inclusion criteria. Of which, we discovered 5 first-order categories of benefits and 5 of barriers of smart home health technologies with further sub-themes that together form the concurrent array of existing knowledge. These categories included, for example, allows older persons to live independently at home, reminds older persons to promote self-care, and alternatively, concerns about usability, cost, and social acceptance. These systematically-derived categories of benefits and barriers could be a starting point for researchers interested in caregiving for older persons to conduct further empirical and reflective research. Furthermore, having this understanding of existing challenges and opportunities associated with smart home health technologies then allows the research and technical communities to collaborate upon a joint foundation to inform policy and improve caregiving for the global aging population.
IMPACT OF OLDER ADULTS’ INTERNET USE ON THE ECONOMIC BURDEN OF INFORMAL CAREGIVING
Authors: Kim Jeehoon , Joo Heesoo , Hageman Sally 
Published: December 2022

Abstract

Objectives
Digital technology enables older adults to live independently by handling health-related tasks or shopping/banking online, thus can reduce care burden. This study examines the impact of older adults’ Internet use on formal and informal care hours and its influence on estimating cost savings with active and potential Internet users.

Methods
Medicare beneficiaries ages 65 and above with functional difficulties were sampled from the 2015 National Health and Aging Trends Study (N=1,806). Care is measured by total hours for help older adults received in the past month, separated by formal and informal care. Internet use for health-related tasks and shopping/banking were measured. A survey weighted two-part model with gamma distribution was estimated. The cost savings of informal caregiving was estimated by a replacement approach.

Results
Older adults' health-related Internet use substantially reduced informal care hours by 27.7% (19.8 hours per month, p &lt; .05), but not for formal care hours. A monthly estimated cost reduction of informal caregiving was $3,094 per an older adult with functional difficulties by applying 2020 median wage of home health aide workers. The annual savings in the cost of informal caregiving associated with older adults’ health-related Internet use is estimated to be $8.1 billion with the active users and additionally $20.1 billion with the potential health-related Internet users in the US. Discussion: Promoting health-related Internet use among older adults with functional difficulties to relieve economic burden of informal caregiving will be discussed.
SUFFERING BUT SATISFIED: OLDER ADULTS’ LIFE SATISFACTION WITHSTANDS DEPRESSION AND DEMENTIA
Authors: Van Vleet Samuel , Bass Danica , Mejia Yenifer Morales , Dube Jeanné , McKinney Brandee , Prentice Kailee , Guillory Logan , Barnett Michael 
Published: December 2022

Abstract
Among older adults with neurocognitive disorders, lower life satisfaction has been linked with poorer aspects of physical and mental health that affect quality of life, including depression. However, these associations between life satisfaction and mental health problems have not been found universally. In this study, we further investigated life satisfaction and depression within clinical and healthy older adult populations. Older adults (N = 98), ages 60 to 90 years either with (n = 25) or without (n = 73) a neurocognitive diagnosis, were administered self-report questionnaires measuring depression and life satisfaction. Results showed that although depression was negatively correlated with life satisfaction among both samples, older adults with dementia had higher depression scores but equivalent life satisfaction scores as older adults without dementia. In fact, both the clinical and healthy samples of older adults averaged on the positive or satisfied half of the life satisfaction scale. Older adults with neurocognitive disorders may generally experience higher depressive symptoms, yet despite challenges to quality of life, they seem to find satisfaction in their daily lives. This may stem from older adults viewing current depressive symptoms as a relatively short-term problem while evaluating life satisfaction across their whole lives. The best protective factors for older adults suffering from dementia and depression may therefore be found both in their present and in their past.
IS CEREBRAL AMYLOID ANGIOPATHY A PRECIPITATING EVENT IN THE ETIOLOGY OF ALZHEIMER’S DISEASE
Authors: Edland Steven , Zarow Chris , Shifflett Benjamin , Flanagan Margaret , White Lon 
Published: December 2022

Abstract
Amyloid plaque and cerebral amyloid angiopathy (CAA) are early neuropathologic changes observed in the setting of clinical Alzheimer’s disease (AD), typically preceding biomarker evidence of intraneuronal tau neurofibrillary tangle (NFT) development and associated cognitive decline. Here we apply structural equation models to explore the potential causal associations between amyloid-beta lesions (i.e. plaques and CAA) and NFTs as they affect cognitive performance in the elderly.Brain autopsy data used in this study are from the Honolulu Asia Aging Study (HAAS) of Japanese American men from the state of Hawaii (n=600), and the Nuns Study (NS) of Roman Catholic Sisters largely from the upper midwestern United States (n=378). Cognitive performance within three years of death was assessed by multi-domain dementia rating scales.We found that neocortical neuritic plaque and CAA effects on cognitive performance were mediated by neocortical NFTs for both the HAAS (p &lt; 0.002) and NS (p &lt; 0.043). There were no direct effects of neuritic plaque and CAA after controlling for the mediating effect of NFTs (p &gt; 0.54).These data are consistent with the hypothesis that the association between neuritic plaque and CAA on cognition is mediated by NFT load. This may inform our understanding of the etiology of NFT lesion pathology in aging and AD. The disruption of arterial smooth muscle function by CAA has predictable effects on glymphatic processes and on the regulation of capillary blood flow. These effects are plausibly relevant to the AD neurodegenerative process, and these pathways deserves continued attention by the AD research community.
DETECTION OF PRECLINICAL AND PRODROMAL ALZHEIMER’S DISEASE USING A MULTIDISEASE DIAGNOSTIC PLATFORM
Authors: DeMarshall Cassandra , Viviano Jeffrey , Emrani Sheina , Godsey George , Sarkar Abhirup , Belinka Benjamin , Libon David , Nagele Robert 
Published: December 2022

Abstract
AD-related pathological changes begin in the brain long before symptoms emerge. In the present study, we demonstrate the utility of a panel of AD-related autoantibodies capable of detecting AD at the earliest points along the AD continuum, including preclinical AD, years before the onset of symptoms, and prodromal AD (mild cognitive impairment, MCI). Using a customized panel of AD-specific autoantibody biomarkers and Luminex xMAP® technology, sera from ADNI subjects with preclinical AD or MCI were screened to demonstrate preclinical and prodromal AD detection. A panel of eight autoantibodies with increased titer in MCI and preclinical AD relative to controls was evaluated using Random Forest and Receiver Characteristic Operating curves for their ability to distinguish diseased subjects from age- and sex-matched controls, as well as from individuals with other neurodegenerative and non-neurodegenerative diseases. Results showed that this panel of biomarkers was capable of differentiating patients with MCI from age- and sex-matched controls with high overall accuracy, sensitivity, and specificity. These biomarkers also identified cognitively normal subjects who later converted to MCI and AD. Furthermore, this autoantibody biomarker panel distinguished MCI and preclinical AD subjects from Parkinson’s disease and breast cancer subjects, demonstrating excellent disease specificity. Results demonstrate the utility of our blood-based autoantibody biomarker panel as an accurate, non-invasive, and inexpensive diagnostic screener, not only for the detection of prodromal AD, but also the earlier, preclinical stages of AD pathology. This multi-disease diagnostic platform has been demonstrated to be useful for multiple neurodegenerative diseases including AD, Parkinson’s disease and Multiple Sclerosis.
A NOVEL FRAMEWORK LINKING MNEMONIC AND HIPPOCAMPAL INTEGRATION TO LATE-LIFE REAPPRAISAL EFFICACY
Authors: Martins-Klein Bruna , Orlovsky Irina , Heideman Kristin 
Published: December 2022

Abstract
Socioemotional theories suggest that surviving challenging experiences enhances emotional resilience with age, yet the role of memories is overlooked in most models of emotion regulation. In parallel, cognitive accounts focus on age-related memory deficits associated with overlapping hippocampal neural representations across unique memories (neural dedifferentiation). We propose a novel framework supporting enhanced late-life reappraisal via hippocampal dedifferentiation of memory representations across current and past experiences. We review classic studies supporting mood benefits from integrated positive narratives following adverse autobiographical events. We also discuss multivariate neuroimaging evidence supporting overlapping hippocampal representations and ventromedial prefrontal cortex (vmPFC) involvement in meaning-making processes. We posit that greater hippocampal dedifferentiation across life memories may facilitate associative binding of current and past stressors as well as reappraisals in vmPFC. This process may provide avenues for generalizing past reappraisals to novel contexts and reducing cognitive demands of reappraisal. In addition, we discuss the possible age-related facilitation of this process, as a greater number of life experiences may become increasingly integrated with one another over the lifespan. These integrated neural associations may serve to make reappraisals from the past more readily accessible and applicable in new contexts over time, increasing routes to positive narratives following stress. We discuss future directions for testing components of the proposed model using multivariate neuroimaging methods. We conclude by briefly reviewing the possible clinical impact of mnemonic emotion regulation in promoting emotional well-being among older adults, using a strengths-based approach that leverages wisdom from experience and neural processes facilitated with age.
SLEEP, COGNITION, AND BRAIN FUNCTION IN OLDER ADULTS WITH CHRONIC KIDNEY DISEASE AND MILD COGNITIVE IMPAIRMENT
Authors: Jeamjitvibool Thanakrit , Hannan Mary , Bronas Ulf 
Published: December 2022

Abstract
Older adults with chronic kidney disease (CKD) are at risk for cognitive impairment and commonly report sleep disturbances. The association between sleep and brain function remains unclear. This cross-sectional study investigated the relationship between sleep, cognition, and brain function in older adults with CKD and mild cognitive impairment (MCI). Older adults with CKD and MCI (n=37, age=68 + 4.93, eGFR=43.7 + 10.98, 73%=Black, 70%=Female), were evaluated via a comprehensive cognitive function battery and brain MR-imaging. Seven-day actigraphy was scored utilizing the Cole-Kripke algorithm to evaluate sleep quality and duration. Ordinary least square regression controlling for age and education quality indicated that &gt;9 hours of sleep, as compared to &lt; 7 hours of sleep, was associated with worse executive function (unstandardized beta=-6.86, 95% CI:-13.19, -0.53, p=.04). Less sleep (&lt; 8 hours) was associated with better learning/memory (unstandardized beta=2.61, 95% CI: 0.84, 4.38, p=.01). Better sleep efficiency was associated with increased global cerebral blood flow (unstandardized beta=3.30, 95% CI: 0.65, 5.95, p=.02). Longer sleep time (&gt;9 hours), as compared to shorter sleep time (&lt; 7 hours), was associated with worse mean diffusivity (unstandardized beta=0.12, 95% CI: 0.03, 0.20, p=.01). Shorter sleep time (&lt; 8 hours, compared to &gt;=8 hours) was associated with better fractional anisotropy of the cingulum (unstandardized beta=0.03, 95% CI: 0.01, 0.05, p=&lt;.001). Sleep duration and quality may be related to cognition and brain function in older adults with CKD and MCI providing a possible avenue for interventions to improve cognitive outcomes in this population.
ARE PAIN APPS USABLE? MHEALTH LITERACY FRAMEWORK
Authors: Milidonis Mary , Menges Carolyn 
Published: December 2022

Abstract
Older adults are at risk for low health literacy and not adhering to self-care. Health professionals are shifting their practices to emphasize wellbeing through health promotion. Mobile pain applications may be a tool to improve health communication and individualize care. Mobile health apps do not always consider the needs of the older adult who may be less comfortable and confident with technology. The purpose of this qualitative review is to explore mobile pain applications for adults with a health literacy framework, and identify facilitators and barriers to usability. Databases that reviewed apps included Google, Google Scholar, ScienceDirect, PubMed, CINAHL plus full text, APTA EBP database, MEDline, and SportDiscus. Fifty-three apps found. Excluded criteria: if there was a cost, targeted for children, and without pain diary. Six apps identified to be specifically relevant to pain intensity, location quality, and impact on life. Mobile Application Rating System (MARS) tool assessed engagement, functionality, aesthetics, information quality, and subjective quality. All apps were engaging, allowed for tracking symptoms and life impact over time. Some apps were difficult to navigate, did not offer education support. Two of the apps individualized pain. Two apps are on only accessible on one app platform. One app allowed for feedback about the app design. Pain mobile health applications can improve tracking, managing and understanding pain for improved mobility and social engagement for older adults. The use of health literacy frameworks with mobile health applications may increase accessibility to care.
IMPACT OF VIBRATION ON TREMOR IN OLDER ADULTS WITH PARKINSON’S DISEASE
Authors: Pretzer-Aboff Ingrid , Elswick R K , Watson Amanda , Sun Minglong , Jung Woosub , Koltermann Ken , Zhou Gang , Cloud Leslie 
Published: December 2022

Abstract
This was a randomized trial to explore the safety and efficacy of the RMBand (Resonate Forward LLC, Delaware) device to alleviate Parkinson’s Disease (PD) tremors. The RMBand applies vibration to the proximal arm and was worn on the side of tremor dominance. Thirty subjects with PD and associated tremors were randomized to receive high vs. low-frequency vibration. Tremor assessments occurred for 20 minutes before, during 20 minutes of continuous vibration, and for 20 minutes immediately post-vibration in a single 60-minute session. Assessments (MDS-UPDRS part 3 and FTM tremor scale) were performed during each of the 3 phases by blinded raters. A quantitative assessment of tremor was performed throughout the session using wearable sensors on the distal arms. Linear mixed models were used for group comparisons. No significant difference was observed between the high and low dose groups in the MDS-UPDRS part 3 or FTM tremor scale (p=0.83 and 0.48 respectively), which may be due to the crude nature of these scales. Quantitative wearable sensor data were used to assess total time with tremors during the pre-vibration, vibration, and post-vibration periods. Time with tremor during the pre-vibration period was significantly greater than that during and post-vibration (p&lt; 0.0001) for both dose groups, suggesting that vibration therapy applied to the proximal arm may suppress PD tremor. No significant adverse events related to vibration therapy occurred. In conclusion, the RMBand appears safe and possibly effective for suppressing PD tremor. Further study is warranted.
FINDINGS FROM HIGH USERS OF VIDEO TELEHEALTH TO DELIVER OCCUPATIONAL THERAPY SERVICES DURING COVID-19
Authors: Gately Megan , Waller Dylan , Metcalf Emily , Moo Lauren 
Published: December 2022

Abstract
Occupational therapy (OT) helps older adults improve their ability to perform day-to-day tasks. Veterans Health Administration (VHA) is the single largest employer of occupational therapy (OT) practitioners in the United States and a forerunner in telehealth. As a result of COVID, OT video visits increased by nearly 2000% from 2019 to 2020. To ascertain barriers and facilitators to this shift in care delivery, we conducted interviews between January and April 2021 with OT practitioners (N=27) who were high users of VA Video Connect (VVC), VHA’s videoconferencing software. OT participants were from rural and urban settings, and had completed an average of 536 VVC appointments each in 2020. Participants used VVC to deliver a variety of OT services, including mental health groups and home safety interventions. Facilitators to VVC included, a) Patient characteristics, such as positive perceptions of VVC and technological skill, b) OT clinician characteristics, like flexibility, level of experience, and desire to increase patient access to care, and, c) VHA’s telehealth infrastructure. Barriers included, a) Patients’ lack of familiarity or skills with technology, particularly older patients, b) challenges translating traditionally hands-on care to video, and c) unreliable internet connectivity, particularly for rural patients. This study broadens our understanding of video telehealth service delivery for care which has historically been delivered in brick-and-mortar settings. Understanding challenges and enablers to video telehealth highlights opportunities to increase access to those who face barriers, such as older, rural patients.
FACTORS INFLUENCING CANCER SURVIVORSHIP AMONG NIGERIAN WOMEN
Authors: Esiaka Darlingtina , Nwakasi Candidus , Chidebe Runcie , Fatai Khadijat Banwo , Orji Gloria 
Published: December 2022

Abstract
Breast cancer is the most common cancer globally and among Nigerian women. With technological and medical advancements, especially in the early detection of chronic illnesses, there is a reduction in cancer deaths, and more women are living as cancer survivors in Nigeria. Despite the increase in the number of cancer survivors, many survivors struggle with life after cancer diagnoses. In this study, we interviewed 30 Nigerian women (Mage = 42.00) who completed cancer therapy in the past 12 months and above, to explore how women who underwent cancer therapy perceive their healing, health, and quality of life. An example of one of the interview questions is “How did cancer diagnoses affect your normal way of life?” Each interview lasted an average of 1 hour. Participant responses were transcribed, and theme coded for analysis. We found that fear of reoccurrence, loss of sense of purpose, shame from physical mutilation related to mastectomy, poor psychological health, social isolation, and ill-treatment from other members of the community were recurring themes across all of the women’s responses. The presence of cancer survivors' support groups and religiosity were important for the experience of life after a cancer diagnosis. Our findings draw attention to the need for interventions targeting cancer survivors. The result further indicates that addressing community perceptions of breast cancer is imperative to ensure the health of breast cancer survivors, especially in low-resource countries.