bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large variations in all-cause and overdose mortality among >13,000 patients in and out of opioid maintenance treatment in different settings: a comparative registry linkage study
Authors: Gabrhelík Roman , Hesse Morten , Nechanská Blanka , Handal Marte , Mravčík Viktor , Tjagvad Christian , Thylstrup Birgitte , Seid Abdu Kedir , Bukten Anne , Clausen Thomas , Skurtveit Svetlana 
Published: September 2023

BackgroundOpioid maintenance treatment (OMT) has the potential to reduce mortality rates substantially. We aimed to compare all-cause and overdose mortality among OMT patients while in or out of OMT in two different countries with different approaches to OMT.MethodsTwo nation-wide, registry-based cohorts were linked by using similar analytical strategies. These included 3,637 male and 1,580 female patients enrolled in OMT in Czechia (years 2000–2019), and 6,387 male and 2,078 female patients enrolled in OMT in Denmark (years 2007–2018). The direct standardization method using the European (EU-27 plus EFTA 2011–2030) Standard was employed to calculate age-standardized rate to weight for age. All-cause and overdose crude mortality rates (CMR) as number of deaths per 1,000 person years (PY) in and out of OMT were calculated for all patients. CMRs were stratified by sex and OMT medication modality (methadone, buprenorphine, and buprenorphine with naloxone).ResultsAge-standardized rate for OMT patients in Czechia and Denmark was 9.7/1,000 PY and 29.8/1,000 PY, respectively. In Czechia, the all-cause CMR was 4.3/1,000 PY in treatment and 10.8/1,000 PY out of treatment. The overdose CMR was 0.5/1,000 PY in treatment and 1.2/1,000 PY out of treatment. In Denmark, the all-cause CMR was 26.6/1,000 PY in treatment and 28.2/1,000 PY out of treatment and the overdose CMR was 7.3/1,000 PY in treatment and 7.0/1,000 PY out of treatment.ConclusionCountry-specific differences in mortality while in and out of OMT in Czechia and Denmark may be partly explained by different patient characteristics and treatment systems in the two countries. The findings contribute to the public health debate about OMT management and may be of interest to practitioners, policy and decision makers when balancing the safety and accessibility of OMT.
Qualifying a Novel Clinical Trial Endpoint (iBOX) Predictive of Long-Term Kidney Transplant Outcomes
Authors: Klein Amanda , Loupy Alexandre , Stegall Mark , Helanterä Ilkka , Kosinski Luke , Frey Eric , Aubert Olivier , Divard Gillian , Newell Kenneth , Meier-Kriesche Herwig-Ulf , Mannon Roslyn , Dumortier Thomas , Aggarwal Varun , Podichetty Jagdeep T. , O’Doherty Inish , Gaber Ahmed Osama , Fitzsimmons William E. 
Published: September 2023

New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute’s Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel secondary efficacy endpoint for kidney transplant clinical trials through European Medicines Agency’s qualification of novel methodologies for drug development. This is the first qualified endpoint for any transplant indication and is now available for use in kidney transplant clinical trials. Although the current efficacy failure endpoint has typically shown the noninferiority of therapeutic regimens, the iBOX Scoring System can be used to demonstrate the superiority of a new immunosuppressive therapy compared to the standard of care from 6 months to 24 months posttransplant in pivotal or exploratory drug therapeutic studies.
Characterization and Genomic Analysis of Fererhizobium litorale gen. nov., sp. nov., Isolated from the Sandy Sediments of the Sea of Japan Seashore
Authors: Romanenko Lyudmila , Otstavnykh Nadezhda , Tanaka Naoto , Kurilenko Valeriya , Svetashev Vasily , Tekutyeva Liudmila , Mikhailov Valery , Isaeva Marina 
Published: September 2023

The taxonomic status of two gram-negative, whitish-pigmented motile bacteria KMM 9576T and KMM 9553 isolated from a sandy sediment sample from the Sea of Japan seashore was defined. Phylogenetic analysis revealed that strains KMM 9576T and KMM 9553 represent a distinct lineage within the family Rhizobiaceae, sharing 100% 16S rRNA sequence similarity and 99.5% average nucleotide identity (ANI) to each other. The strains showed the highest 16S rRNA sequence similarities of 97.4% to Sinorhizobium garamanticum LMG 24692T, 96.9% to Ensifer adhaerens NBRC 100388T, and 96.8% to Pararhizobium giardinii NBRC 107135T. The ANI values between strain KMM 9576T and Ensifer adhaerens NBRC 100388T, Sinorhizobium fredii USDA 205T, Pararhizobium giardinii NBRC 107135T, and Rhizobium leguminosarum NBRC 14778T were 79.9%, 79.6%, 79.4%, and 79.2%, respectively. The highest core-proteome average amino acid identity (cpAAI) values of 82.1% and 83.1% were estimated between strain KMM 9576T and Rhizobium leguminosarum NBRC 14778T and ‘Rhizobium album’ NS-104, respectively. The DNA GC contents were calculated from a genome sequence to be 61.5% (KMM 9576T) and 61.4% (KMM 9553). Both strains contained the major ubiquinone Q-10 and C18:1ω7c as the dominant fatty acid followed by 11-methyl C18:1ω7c and C19:0 cyclo, and polar lipids consisted of phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, an unidentified aminophospholipid, and two unidentified phospholipids. Based on phylogenetic and phylogenomic analyses, and phenotypic characterization, strains KMM 9576T and KMM 9553 are concluded to represent a novel genus and species, for which the name Fererhizobium litorale gen. nov., sp. nov. is proposed. The type strain of the type species is strain KMM 9576T (=NRIC 0957T).
Impact of Entrepreneurial Camp on Students’ Entrepreneurial Attitudes
Authors: Brandt Tiina 
Published: September 2023

Entrepreneurial career choices are impacted by entrepreneurial mindset, family background and cultural values. Entrepreneurial mindset includes for example innovativeness, proactiveness, and risk-taking capacity, and entrepreneurial education has been found out useful in enhancing these qualities. Here the interest is to see how the intensive 3-weeks innovation and entrepreneurial camp impacts on the students’ entrepreneurial attitudes compared to international data sample. The 95 students representing mostly USA and European countries filled in the questionnaire which focused on identifying qualities they would need if they would start own business. This data set was compared with the data over 1000 students from various countries. Several differences were found, indicating that those students, who have learnt profoundly about entrepreneurship emphasize different qualities than those with more general level knowledge.
Hygienic assessment of potassium intake from food
Authors: Brusentsova A. V. , Guseva P. A. , Pospelova I. A. , Turchaninov D. V. , Kozubenko O. V. 
Published: September 2023

Aim. To assess the level of potassium intake among the adult population in Western Siberia.Materials and methods. The actual level of potassium intake from food products was assessed by surveying a representative sample of 441 adults in the Omsk region (Russia) using a questionnaire of food consumption frequency in 2019–2020.Results. The median daily potassium intake in the studied sample was 2620.9 mg/day (2005.97; 3456.10), which corresponded to the level of potassium intake in other Russian regions and other countries. This level was found to be significantly lower than that recommended by WHO. The share of adult population with a potassium consumption below physiological requirements in the Omsk region was 39.2 ± 2.3%. No significant differences were observed in potassium intake between men and women (except for the age group of 65 years and older), as well as between different age groups. The main potassium sources were established to be vegetables (37.8%), fruits (16.5%), potatoes (9.2%), fresh tomatoes (8.7%), fresh apples (8.0%), and soups (6.9%). An increase in age was associated with a decrease in potassium intake from confectionery and beverages. At the same time, the contribution of such food groups as ‘porridge and pasta’ and ‘fish and seafood’ increased. In women, vegetables and fruits made a slightly greater contribution as potassium sources. In men, these were bakery and meat products.Conclusion. Insufficient potassium intake among the large share of adult population in the Omsk region can be a significant risk factor in the development of arterial hypertension, which requires preventive measures.
Elimination of increased risk of acute angle closure glaucoma in eyes with a short anteroposterior axis by preventive phacoemulsification
Authors: Sorokin E. L. , Marchenko A. N. , Pashentsev Ya. E. , Samokhvalov N. V. 
Published: September 2023

Aim. A clinical analysis of the efficacy of eliminating the risk of acute glaucoma attack by performing preventive minimally invasive cataract surgery in patients at such a risk.Materials and methods. In total, 70 eyes with a short anteroposterior axis and a thickened lens shape, and an increased risk of acute glaucoma attack were investigated. The main group included 45 patients subjected to preventive phacoemulsification (PE), and the reference group included 25 patients not subjected to PE. According to the position of the ciliary body (middle and posterior), each group was divided into two subgroups. The parameters of lens cross-sectional area (CSA) and anterior chamber cross-sectional area (ACCSA) were studied using B-scan ultrasonography of the anterior eye segment.Results. On the 2–3rd day after PE, the main group showed an increase in the anterior chamber depth and ACCSA values, along with an opening of the anterior chamber angle (ACA) to grade 3. These indicators remained at the same level by the end of the 4–5 year observation period. After 1–3 years, the reference group demonstrated a statistically significant decrease in the anterior chamber depth and ACCSA values, a narrowing of the ACA width, as well as an increase in intraocular pressure. After 4–5 years, the ACA was completely closed (0°), and the CSA indicator significantly increased.Conclusion. Immediately after preventive surgery, all patients of the main group showed a statistically significant improvement in the studied parameters, which remained stable following the period of 4–5 years.
The work of a pediatric ophthalmological department during COVID-19
Authors: Mozhilevskaya E. S. , Melnikov V. Ya. , Titovets V. V. , Chramenkova L. S. 
Published: September 2023

Aim. To analyze the work of the pediatric ophthalmological department of eye microsurgery of Regional Clinical Hospital No. 2 (Vladivostok, Russia) during the COVID-19 pandemic.Materials and methods. The research materials included reports of the chief freelance pediatric ophthalmologist of the Primorsky Krai, as well as outpatient and inpatient records of the pediatric ophthalmological department of Regional Clinical Hospital No. 2, compiled during 2020 and 2021. A retrospective analysis of the incidence structure in 2020 and 2021 was carried out. In total, 1498 patients who received hospital treatment during the specified period were included in the study. Data analysis was carried out using MS Excel methods of descriptive statistics. The data were displayed using charts, as well as in the form of absolute numbers and a percentage of the total number of operations.Results. In 2020, the average length of patient stay in the hospital was lower than that in 2021. During this period, the number of hospitalized children decreased by more than twice, which is reflected in Table 1 and Fig. 1. The share of patients with eye trauma requiring emergency conservative and surgical care increased. In 2021, out of 924 treated patients, 506 needed surgical treatment, which was performed according to indications.Conclusion. During the COVID-19 pandemic, planned hospitalization was suspended followed by introduction of a special sanitary and epidemiological regime. In 2020–2021, 1498 children received ophthalmological inpatient care. In comparison with 2020, the number of surgical interventions, including elective operations, increased by 193 and amounted to 62%. This was related to lifting of the restrictions on planned hospitalization. Overall, 40% fewer children received treatment compared to pre-COVID years.
Problems of healing chronic wounds
Authors: Babenko N. M. , Litvinova O. B. , Pavlov S. B. , Kumechko M. V. , Komarchuk V. V. 
Published: September 2023

Aim. The work aimed to analyze and highlight the problems of chronic wound healing and modern methods of stimulation of reparative processes according to literature sources.
An analysis of the scientific literature was carried out, in which views on the problems of wound healing are presented, taking into account the factors affecting the formation and healing of chronic wounds, and modern methods that stimulate reparation processes. Identifying the problems of wound healing will allow a comprehensive approach to the assessment of the wound process, taking into account the factors affecting the healing of injuries.
Modern scientists are actively discussing the problems of wound healing, researching factors influencing the reparative process, including the high prevalence of chronic wounds, diagnosis and treatment of wound infections, age of patients, and state of immunity. In the case of systemic diseases, such as diabetes, cardiovascular pathology, etc., there is a violation of microcirculation, and as a result, there are violations of the phasing of reparative processes at the cellular level. As a result, the alteration process does not end and the process becomes chronic.
In case of a mechanical injury, when adaptation reserves are reduced, primarily of the neurohumoral system, a key role is played by the disruption of regulatory mechanisms at the cellular level. Wound treatment requires surgical treatment, stimulation of angiogenesis, and other reparative processes at the systemic and local levels.
In recent years, various methods of stimulating reparative processes have been used in clinical practice to treat wounds: local administration of recombinant growth factors, use of platelet-rich plasma, biotechnological wound dressings, and artificial skin substitutes. One of the most promising areas of wound treatment is the development of methods for targeted activation of stem cells. However, there are still insufficient data for the practical application of this method. Clinically effective and safe methods are still being developed. Physical methods are promising for improving the healing of chronic wounds. However, the selection of optimal parameters for physical action continues to be an urgent task. Despite the positive results obtained using the methods described above, there is a need for additional experimental studies and randomized controlled trials.
Conclusions. Chronic wounds develop as a result of severe systemic diseases, and major mechanical injuries against the background of a decrease in physiological reserves due to emotional and psychological stress, obesity, etc. Choosing the right method of influencing the reparative process, taking into account the leading mechanism of damage repair, becomes very important to ensure the best chance for optimal wound healing.
III–V gain region/Si waveguide hybrid lasers by chip-on-wafer hydrophilic bonding process using UV-ozone treatment
Authors: Kikuchi Takehiko , Kurokawa Munetaka , Fujiwara Naoki , Inoue Naoko , Hiratani Takuo , Nitta Toshiyuki , Mitarai Takuya , Itoh Yuhki , Lee Chang-Yong , Furuya Akira , Oiso Yoshitaka , Nishiyama Nobuhiko , Yagi Hideki 
Published: September 2023

Abstract
The direct bonding process of InP chips on a silicon-on-insulator (SOI) wafer is investigated using surface hydrophilization by UV-ozone treatment. The influence of the treatment on surface roughness is observed by atomic force microscopy, and found to be negligibly small. A high-quality III–V/Si bonding interface without crystal defects is verified in a scanning transmission electron microscope observation. The III–V layers remaining on the SOI wafer after the removal process of the InP substrate show uniform photoluminescence intensity over the whole region of the chip, indicating a bonding interface without the influence of lateral etching and peeling-off. From this bonding process, Fabry–Perot lasers with III–V gain and Si waveguide regions are fabricated, and cw operation is successfully achieved at a stage temperature from 20 °C to 85 °C. Stable operation is also confirmed from the changes of threshold current in the aging test (200 mA at 85 °C) after 2000 h.
Analisis Bibliometrik Tentang Tren Penelitian Mengenai Manajemen Pengetahuan Berdasarkan Afiliasi Penulis dari Indonesia
Authors: Soesanto Hari , Handalani Radite Teguh 
Published: September 2023

Knowledge management is essential for an organization, especially in managing the knowledge possessed by its human resources to be more effective in achieving its goals. In its development, research trends on global knowledge management have crossed national borders (across countries). However, research written by authors whose affiliates are from Indonesia is exciting and essential to study in research mapping based on the author's country affiliation and its various findings. This study aims to map an outline of the current state of research on knowledge management based on author affiliations from Indonesia and see future research opportunities, especially related to research trends and novelties. The method used is bibliometric analysis with the help of VOSviewer software and the Scopus database. The co-authorship and co-occurrence of keywords were analyzed on 125 documents in 2017-2021. The results showed 12 author network clusters and five keyword clusters. The most dominant keywords that emerged included knowledge management, knowledge, Indonesia, knowledge management systems, and e-learning.
(Manajemen pengetahuan sangat penting bagi suatu organisasi terutama dalam mengelola pengetahuan yang dimiliki oleh sumber daya manusia pada organisasi supaya lebih efektif dalam mencapai tujuannya. Dalam perkembangannya, tren penelitian tentang manajemen pengetahuan secara global telah melampaui batas negara (lintas negara). Akan tetapi penelitian yang ditulis oleh penulis yang afiliasinya dari Indonesia menarik dan penting dan relatif baru, untuk diteliti dalam rangka pemetaan penelitian berdasarkan afiliasi negara penulis beserta berbagai temuannya. Penelitian ini bertujuan untuk memetakan garis besar keadaan penelitian terkini tentang manajemen pengetahuan berdasarkan afiliasi penulis dari Indonesia dan melihat peluang penelitian ke depan terutama berkaitan trend penelitian dan kebaruan (novelty). Metode yang digunakan yaitu analisis bibliometrik dengan bantuan perangkat lunak VOSviewer dan database Scopus. Analisis co-authorship dan co-occurrence kata kunci dilakukan terhadap 125 dokumen pada tahun 2017-2021. Hasil penelitian menunjukkan bahwa terdapat 12 klaster jejaring penulis dan terdapat 5 klaster kata kunci. Kata kunci yang paling dominan muncul antara lain knowledge management, knowledge, Indonesia, knowledge management system, dan e-learning).
Метод аналізу емоційного забарвлення текстів за допомогою графових згорткових нейронних мереж
Authors: Yaroshenko O. 
Published: September 2023

У роботі досліджено графові згорткові нейронні мережі, як перспективний напрямок аналізу емоційного забарвлення текстів. Детально описано конструкції емоцій, їх природу та сутність. Зазначено основні способи класифікації емоцій такі як бінарна класифікація емоцій, класифікація емоцій з кількома мітками та багатокласова класифікація емоцій. Окреслено принцип формування нейронних мереж графів та наголошено, що моделі побудовані на графових нейронних мережах зазвичай не враховують семантичне значення тексту, що стосується значення, визначеного відношеннями між словами в реченні, що є важливим для класифікації емоцій тексту, що аналізується. Відокремлено поняття семантичного та синтаксичного аналізу тексту, описано підходи до реалізації. Наголошено, що семантичне представлення відображає зміст тексту в досить структурованій формі з виділенням різних представлень: представлення абстрактного значення, універсальна концептуальна когнітивна анотація, дволексичні семантичні залежності та універсальна декомпозиційна семантика. Зазначається, що модель синтаксичного аналізатора являє собою семантичний аналізатор на основі графів, який вирішує проблему синтаксичного аналізу конституентів. Охарактеризовано рівні моделі та наведено принцип роботи. Математично представлено ациклічний орієнтовний граф системи аналізу емоційного забарвлення тексту, описано матрицю ознак та матрицю суміжності. Наведено модель нейронної мережі, яка працює з графоструктурованими даними, яка складається з трьох основних шарів. Запропоновано підхід до навчання такої нейронної мережі. Наголошено, що модель використовує конкатенацію вбудованих слів і синтаксичних вбудованих елементів у якості вхідних даних. Як результат отримано згорткову нейронну мережу для аналізу емоційного забарвлення текстів та проаналізовано її характеристики порівняно з іншими типами нейронних мереж. Зроблено висновок, що хоча й точність розробленого методу є досить високою, інші архітектури нейронних мереж краще підходять для задачі сентимент аналізу.
Is there selective retroactive memory enhancement in humans?: a meta-analysis
Authors: Koevoet Damian , Postma Albert 
Published: September 2023

AbstractMemory is an adaptive and flexible system that preferentially stores motivationally relevant information. However, in some cases information that is initially irrelevant can become relevant at a later time. The question arises whether and to what extent the memory system can retroactively boost memories of the initially irrelevant information. Experimental studies in animals and humans have provided evidence for such retroactive memory boosting. Additionally, these studies suggest that retroactive memory enhancement (RME) can be selective to the semantic meaning of the material. Nonetheless, recent experimental work could not replicate these findings, posing the question whether the selective RME effect is reliable. To synthesize the available evidence, we conducted meta-analyses of 14 experiments. Although the classical meta-analytic procedure suggested a small selective RME effect, Cohen’s dz = 0.16, when accounting for small-study bias using robust Bayesian meta-analysis the null hypothesis was supported, Cohen’s dz = 0.02, BF01 = 3.03. Furthermore strong evidence was found for a bias due to small-study effects, BF10 = 11.39. Together, this calls the reliability of a selective RME effect into question.
Efecto de las variaciones climáticas y atmosféricas en el rendimiento energético de los paneles solares monofaciales, Chachapoyas, Amazonas
Authors: Espinoza Canaza Fernando Isaac 
Published: September 2023

El objetivo fue analizar los efectos de las variaciones climáticas y atmosféricas en el rendimiento de los paneles solares monofaciales. El estudio se realizó en Chachapoyas, Amazonas, la metodología aplicada consistió en registrar datos por 12 meses, desde las 6:00 am a 18:00 horas, promediándose por día cada uno de los parámetros climáticos y atmosféricos; y la radiación solar se tomó los datos de la estación meteorológica del INDES-CES localizado en el campus de la UNTRM. Los resultados obtenidos presentaron una irradiación anual de 4.74 km/m2, la energía acumulada anual de enero a diciembre de 2021 alcanzó 1710.34 kWh/m2. La eficiencia energético anual alcanzó el 68.71 %. La radiación solar, para los días nublados, combinado y soleados o despejados, fueron 599.02 w/m2, 785.95 w/m2 y 1004.22 w/m2. La eficiencia energética, está relacionado con la velocidad del viento para los tres tipos de días y fueron de 9.40 km/h, 7.20 km/h y 5.80 km/h, y la temperatura promedio fue 26.80 °C, 28.70 °C y de 30.60 °C; la humedad en invierno alcanzó mínimo 38 % RH y máximo a 73 % RH, en promedio 52.61 % RH; y mínimo 30.00 % RH y máximo 74.00 % RH en promedio 51.48 % RH en varano. El rendimiento energético fue 9240.90 kW en invierno y 9301.80 kW para verano.