bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type of cancer and complementary and alternative medicine are determinant factors for the patient delay experienced by children with cancer: A study in West Java, Indonesia
Authors: Sari Nur Melani , Devansyah Sultan , Modjaningrat Ismiana , Suryawan Nur , Susanah Susi , Rakhmillah Lulu , Wahyudi Kurnia , Kaspers Gertjan J. L. 
Published: January 2023

AbstractIntroductionMost pediatric cancer patients in developing countries present at an advanced stage due to delayed diagnosis, being an important barrier to effective care. The objective of this study was to evaluate the associated factor of patient delay and explore significant parental practice‐associated risk factor to patient delay.MethodsThis was a sequential mixed methodology, utilizing data from the Indonesian Pediatric Cancer Registry for clinical variables and completed interviews with parents using structured questionnaires to obtain their sociodemographic data. A binary logistic regression analysis model was fitted to identify factors associated with patient delay. Additional semi‐structured interviews related to parental practice of using complementary and alternative medicine (CAM) were administered to 30 parents. Thematic framework analysis was performed on qualitative data to explore determinant factors of parental practice of using CAM.ResultsWe interviewed 356 parents with children with cancer. The median patient delay was 14 days (interquartile range [IQR]: 6–46.5 days). The most extended delay was in patients with malignant bone tumors (median 66, IQR: 14–126). In multivariable logistic regression analysis, solid cancer (odds ratio [OR] = 5.22, 95% confidence interval [CI]: 2.79–9.77, p < .001) and use of CAM (OR = 1.86, 95% CI: 1.13–3.08, p = .015) were associated with patient delay. Qualitative interviews highlighted key issues relative to determinant parental factors using CAM, including vague initial childhood cancer symptoms, parental health‐seeking behavior, CAM availability and accessibility, also barriers of healthcare facilities.ConclusionType of cancer and use of CAM are essential factors that cause patient delay. It should be addressed in the future childhood cancer awareness and childhood cancer diagnosis pathway.
Informed consent for expanded carrier screening: Past, present, and future
Authors: Rink Britton D. 
Published: January 2023

AbstractHistory, law, bioethics, and geocultural influences all have impacted the modern application of informed consent. It is a complex, multilayered process to communicate information and obtain voluntary patient permission before a health care intervention. Lack of provider education about genetic disorders, complexities of advanced genomic technologies, limited time during patient encounters, and low health literacy within a population all represent challenges to effective communication. There is no consensus on how informed consent in reproductive genetics is optimally obtained. Expanded carrier screening (ECS) is purposed to simultaneously test for a large list of diseases in a pan‐ethnic manner. The increased use of ECS is driven by advances in genomic technologies, decreased cost, an improved understanding of single gene disorders, and in support of reproductive autonomy. Academic organizations recommend pretest counseling when patients consider ECS, yet best practice is not established. Ongoing research is needed to determine how optimally implement informed consent given the increased complexity of ECS.
Internet‐delivered cognitive behavioural therapy for depression and anxiety in breast cancer survivors: Results from a randomised controlled trial
Authors: Akkol‐Solakoglu Selin , Hevey David 
Published: January 2023

AbstractObjectiveDepression and anxiety symptoms are common among breast cancer survivors. Access to evidence‐based psychological therapy remains a major challenge. Despite the proven effectiveness of internet‐delivered cognitive behavioural therapy (iCBT) in reducing depression and anxiety, the research with cancer survivors is still limited. This study evaluated the effectiveness of an iCBT intervention on depression and anxiety, quality of life, fear of recurrence, active and avoidant coping, and perceived social support in breast cancer survivors.MethodsSeventy‐two participants were randomised to a 7‐module guided iCBT intervention or treatment‐as‐usual (TAU). Depression and anxiety symptoms were measured using the Hospital Anxiety and Depression Scale total score (HADS‐T). The secondary measures included the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC‐QLQ), Breast Cancer Worry Scale (CWC), Brief Coping Orientation to Problems Encountered (Brief COPE), Medical Outcomes Study Social Support Survey (MOS‐SSS). All were completed at baseline, post‐intervention, and 2‐month follow‐up. Groups were compared using linear mixed models.ResultsAlthough non‐significant, iCBT group had lower HADS‐T scores than TAU at post‐intervention. This difference was statistically significant at 2‐month follow‐up (Hedge's g = −0.94). No significant group‐by‐time interaction effects were found for quality of life, fear of recurrence, active coping, avoidant coping, and perceived social support. The intervention adherence was acceptable; 52.8% (n = 28) completed all seven modules.ConclusionsiCBT intervention demonstrated its preliminary effectiveness in reducing distress in breast cancer survivors.
Exploring the structural and dynamic differences between human carnosinase I (CN1) and II (CN2)
Authors: Tancharoen Chompoonuch , Tovivek Borvornwat , Niramitranon Jitti , Kityakarn Sutasinee , Luksirikul Patraporn , Gorinstein Shela , Pongprayoon Prapasiri 
Published: January 2023

AbstractHuman carnosinases (CNs) are dimeric dipeptidases in the metallopeptidase M20 family. Two isoforms of carnosinases (Zn2+‐containing carnosinase 1 (CN1) found in serum and Mn2+‐carnosinase 2 (CN2) in tissue) were identified. Both CNs cleave histidine‐containing (Xaa‐His) dipeptides such as carnosine where CN2 was found to accept a broader spectrum of substrates. A loss of CN function, resulting in a high carnosine concentration, reduces risk for diabetes and neurological disorders. Although several studies on CN activities and its Michaelis complex were conducted, all shed the light on CN1 activity where the CN2 data is limited. Also, the molecular details on CN1 and CN2 similarity and dissimilarity in structure and function remain unclear. Thus, in this work, molecular dynamics (MD) simulations were employed to study structure and dynamics of human CN1 and CN2 in comparison. The results show that the different catalytic ability of both CNs is due to their pocket size and environment. CN2 can accept a wider range of substrate due to the wider mouth of a binding pocket. The L1 loop seems to play a role in gating activity. Comparing to CN2, CN1 provides more electronegative entrance, more wettability, and higher stability of catalytic metal ion‐pair in the active site which allow more efficient water‐mediated catalysis. The microscopic understanding obtained here can serve as a basis for CN inhibition strategies resulting in higher carnosine levels and consequently mitigating complications associated with diseases such as diabetes and neurological disorder.
Severe unilateral nephrolithiasis and recurrent colic in a horse
Authors: Barrantes Murillo Daniel Felipe , Ramaker Erica , Burke Megan , Walker Ryan , Negrão Watanabe Tatiane Terumi 
Published: January 2023

AbstractUrolithiasis is an uncommon disorder reported in horses. Calculi located in the kidneys and ureters are often underdiagnosed. Associated clinical signs include weight loss, anorexia, haematuria, dysuria, colic and polyuria/polydipsia. A 26‐year‐old Thoroughbred gelding was referred for evaluation of an acute colic episode of 5‐hour duration. Haematologic analysis revealed increased serum creatine kinase and creatinine concentrations. Abdominocentesis yielded serosanguineous, mildly cloudy fluid with a lactate of 9.6 mmol/L (<2 mmol/L). Exploratory laparotomy was recommended. Surgical intervention was declined, and the horse was humanely euthanased. Limited postmortem evaluation was performed. A 3.633 kg nephrolith measuring 23.6 × 16.2 × 8.9 cm was completely effacing the left kidney. Crystallography and infrared spectroscopy (attenuated total reflection and Fourier transform infrared) revealed a 100% calcium carbonate nephrolith. Carbonate calcium calculi are the most common subtype in horses. Nephrolithiasis should be considered as a differential diagnosis for colic and haematologic evidence of azotaemia in horses.
Simultane Entfernung von organischen Spurenstoffen und Phosphor aus kommunalem Abwasser unter Einsatz einer Adsorptions‑/Fällmittelsuspension
Authors: Reif Daniela , Weisz Liad , Kobsik Kara , Schaar Heidemarie , Saracevic Ernis , Krampe Jörg , Kreuzinger Norbert 
Published: January 2023

ZusammenfassungIn der vorliegenden Studie wurde die Wirksamkeit einer Adsorptions‑/Fällmittel-Prototypsuspension der Firma Donau Chemie AG zur simultanen Entfernung von Spurenstoffen und Phosphor aus kommunalem Abwasser untersucht. Die Suspension enthält Polyaluminiumchlorid zur Fällung von gelöstem Orthophosphat, Pulveraktivkohle (PAK) zur Adsorption von organischen Spurenstoffen sowie anorganische Stabilisatoren, die die Suspension der PAK unterstützen. Vergleichende Laborversuche mit herkömmlicher PAK und der Prototypsuspension mit einem PAK-Gehalt von 16,5 % wurden mittels zweier unabhängiger Methoden (Spurenstoffanalytik und In-vitro-Bioassays) bewertet. Die Ergebnisse zeigten, dass die Suspension zu einer Verbesserung der Oberflächeneigenschaften der Aktivkohle führt und somit eine höhere Anzahl von bekannten und unbekannten Substanzen adsorbiert werden kann. Die Anwendbarkeit der Suspension wurde in drei verschiedenen Abwässern untersucht und ist vor allem vom Verhältnis zwischen gelöstem organischem Kohlenstoff (dissolved organic carbon – DOC) und Gesamtphosphor im Zulauf abhängig. Bei höheren DOC-Konzentrationen ist ein höherer Anteil an PAK in der Suspension notwendig, um eine massive Überdosierung des Fällmittels zu verhindern. Während des großtechnischen Versuchs, der auf einer kommunalen Kläranlage durchgeführt wurde, kam es zu einem Anstieg der prozentuellen Entfernung um mehr als 90 % für Carbamazepin, mehr als 50 % für Diclofenac und Metoprolol und um etwa 30 % für Benzotriazol. Bei einer konstanten Dosiermenge von 90 L d−1 wurde die auf Basis der Labortests erwartete Spurenstoffentfernung von mehr als 75 % für alle Stoffe erreicht. Der Prototyp zeigte sich als einfacher zu lagern und zu dosieren als herkömmliche PAK. Weiters kann die vorhandene Infrastruktur für die chemische Phosphorfällung für die organische Spurenstoffentfernung mitgenutzt werden.
Testing the environmental buffering hypothesis of cooperative breeding in the Seychelles warbler
Authors: Borger Mirjam J. , Richardson David S. , Dugdale Hannah , Burke Terry , Komdeur Jan 
Published: January 2023

AbstractSpecies are facing environmental challenges caused by rapidly changing environments. Globally, extreme weather events, like droughts or extreme rainfall, are increasing in frequency. Natural selection usually acts slowly, while adaptations through phenotypic plasticity are limited. Therefore, organisms may utilise other mechanisms to cope with such rapid change. Cooperative breeding is hypothesised to be one such mechanism, as helpers could increase survival probabilities of offspring, especially in harsh years. Rainfall is a cue for onset of breeding in many tropical species, to ensure young are born when food abundance is highest. Using 21 years of data, we investigate the effect of rainfall on social behaviour and life history in the insectivorous Seychelles warbler (Acrocephalus sechellensis), a facultative cooperative breeder. We found that low rainfall is associated with reduced reproductive output and possibly with decreased survival. However, there were no statistical differences in response between groups with helpers, groups with only non-helping subordinates, and breeding pairs without subordinates. With low rainfall, more sons (the sex less likely to help) were produced, and those subordinate males already present were less likely to help. Thus, in contrast to expectations, cooperative breeding does not seem to buffer against harsh environments in Seychelles warblers, indicating that group living may be costly and thus not a mechanism for coping with changing environments. Our study showed that the interaction between the environment and life histories, including social behaviour, is complex, but that this interaction is important to consider when studying the impact of changing environments on species survival.
Prevention of occupational dysphonia in scientific university personnel: A cross-sectional study
Authors: Lücking Christiane 
Published: January 2023

Abstract
Aim
The aim of the study was to identify occupational and individual factors that influence the occurrence of voice problems in university staff and to investigate whether there is a link between voice problems and physical, psychological or functional changes?

Subject and methods
The voices of university teachers are exposed to increased stress. As members of the group of professional speakers, they have an increased prevalence of developing a voice disorder, so-called dysphonia. In the worst case, chronic, occupational dysphonia can occur. In an empirical-quantitative study in form of a cross-sectional study in Germany, an online questionnaire was used to determine whether university teaching staff is more frequently affected by voice problems than their colleagues in the administrative sector.

Results
The results show that dry room climate, background noise, poor spatial acoustics, lack of breaks, and increasing age influence the occurrence of voice problems in university teachers. Teaching staff is therefore more frequently affected by impaired vocal function due to frequent throat clearing/coughing and a raspy, hoarse and scratchy voice than their administrative colleagues. In addition, there is a need for regular training and counselling.

Conclusion
In order to prevent the development of occupational dysphonia among university teachers, diagnostic, practical and theoretical interventions for the target group are needed. To this end, the appropriate structural and personnel conditions must be created in the university environment.
Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study
Authors: Ishikawa Emi , Yokoyama Yuta , Chishima Haruna , Kasai Hidefumi , Kuniyoshi Ouki , Kimura Motonori , Hakamata Jun , Nakada Hideo , Suehiro Naoya , Nakaya Naoki , Nakajima Hideo , Ikemura Shinnosuke , Kawada Ichiro , Yasuda Hiroyuki , Terai Hideki , Jibiki Aya , Kawazoe Hitoshi , Soejima Kenzo , Muramatsu Hiroshi , Suzuki Sayo , Nakamura Tomonori 
Published: January 2023

AbstractBackground: Potential novel strategies for adverse event (AE) management of osimertinib therapy, including therapeutic drug monitoring and the use of biomarkers, have not yet been fully investigated. This study aimed to evaluate (1) the relationship between exposure to osimertinib, especially its active metabolites (AZ5104 and AZ7550), and AEs, and (2) the relationship between germline polymorphisms and AEs. Methods: We conducted a prospective, longitudinal observational study of 53 patients with advanced non-small cell lung cancer receiving osimertinib therapy from February 2019 to April 2022. A population pharmacokinetic model was developed to estimate the area under the serum concentration–time curve from 0 to 24 h (AUC0–24) of osimertinib and its metabolites. Germline polymorphisms were analyzed using TaqMan® SNP genotyping and CycleavePCR® assays. Results: There was a significant association between the AUC0–24 of AZ7550 and grade ≥ 2 paronychia (p = 0.043) or anorexia (p = 0.011) and between that of osimertinib or AZ5104 and grade ≥ 2 diarrhea (p = 0.026 and p = 0.049, respectively). Furthermore, the AUC0–24 of AZ5104 was significantly associated with any grade ≥ 2 AEs (p = 0.046). EGFR rs2293348 and rs4947492 were associated with severe AEs (p = 0.019 and p = 0.050, respectively), and ABCG2 rs2231137 and ABCB1 rs1128503 were associated with grade ≥ 2 AEs (p = 0.008 and p = 0.038, respectively). Conclusion: Higher exposures to osimertinib, AZ5104, and AZ7550 and polymorphisms in EGFR, ABCG2, and ABCB1 were related to higher severity of AEs; therefore, monitoring these may be beneficial for osimertinib AE management.
Chemical expansion of CeO2−δ and Ce0.8Zr0.2O2−δ thin films determined by laser Doppler vibrometry at high temperatures and different oxygen partial pressures
Authors: Kohlmann Dhyan , Wulfmeier Hendrik , Schewe Marvin , Kogut Iurii , Steiner Carsten , Moos Ralf , Rembe Christian , Fritze Holger 
Published: January 2023

AbstractThe chemical expansion of ceria (CeO2−δ) and ceria-zirconia (Ce0.8Zr0.2O2−δ, CZO80) thin films is investigated by high-temperature laser Doppler vibrometry (LDV) at temperatures from 600 to 950 °C. The films are deposited on single-crystalline 8 mol-% yttria-stabilized zirconia substrates, which act as pumping cells to adjust oxygen non-stoichiometry in the thin films. Oxygen deficiency causes film expansion, leading to mechanical strain that bends the sample. The total displacement, i.e., the sum of bending and film-thickness change, is determined contact-less by LDV. A differential laser Doppler vibrometer (D-LDV) is realized to enable measurements on a very long time scale, which is necessary due to the long equilibrium times of the ceramic films. These displacements are compared to those acquired with a commercial single-point laser Doppler vibrometer (SP-LDV) for motions above 1 Hz. Here, both devices yield similar results. CZO80 films are found to bend a substrate much more than ceria films under similar experimental conditions. A model describing the displacement of the sample is derived from the Stoney model and applied to calculate deflections using literature data. The displacements at the center of the CZO80 sample measured with the SP-LDV increase from 0.18 nm at 10 Hz and 600 °C to 32.7 nm at 0.1 Hz and 800 °C. For ceria, the displacements range from 1.6 nm (10 Hz, 800 °C) to 79.4 nm (0.1 Hz, 900 °C). The D-LDV enables the detection of quasi-static displacements at very low frequencies. The ceria sample exhibits 218 nm at 0.001 Hz and 800 °C.
Mandible segmentation from CT data for virtual surgical planning using an augmented two-stepped convolutional neural network
Authors: Pankert Tobias , Lee Hyun , Peters Florian , Hölzle Frank , Modabber Ali , Raith Stefan 
Published: January 2023

Abstract
Purpose
For computer-aided planning of facial bony surgery, the creation of high-resolution 3D-models of the bones by segmenting volume imaging data is a labor-intensive step, especially as metal dental inlays or implants cause severe artifacts that reduce the quality of the computer-tomographic imaging data. This study provides a method to segment accurate, artifact-free 3D surface models of mandibles from CT data using convolutional neural networks.

Methods
The presented approach cascades two independently trained 3D-U-Nets to perform accurate segmentations of the mandible bone from full resolution CT images. The networks are trained in different settings using three different loss functions and a data augmentation pipeline. Training and evaluation datasets consist of manually segmented CT images from 307 dentate and edentulous individuals, partly with heavy imaging artifacts. The accuracy of the models is measured using overlap-based, surface-based and anatomical-curvature-based metrics.

Results
Our approach produces high-resolution segmentations of the mandibles, coping with severe imaging artifacts in the CT imaging data. The use of the two-stepped approach yields highly significant improvements to the prediction accuracies. The best models achieve a Dice coefficient of 94.824% and an average surface distance of 0.31 mm on our test dataset.

Conclusion
The use of two cascaded U-Net allows high-resolution predictions for small regions of interest in the imaging data. The proposed method is fast and allows a user-independent image segmentation, producing objective and repeatable results that can be used in automated surgical planning procedures.
Positive Ethnic Choice Effects are Persistent Over Time but not Across Minority Generations: Evidence from Switzerland
Authors: Nennstiel Richard 
Published: January 2023

AbstractMany empirical studies have demonstrated positive ethnic choice effects at the transition to upper secondary education. This means that ethnic minority students—given the same academic performance, parental resources and type of school at lower secondary level—aspire to more demanding educational programs than ethnic majority students. Previous research has often examined only single cohorts of school-leavers and has rarely considered differences between ethnic minority generations. Therefore, little is known about the extent to which these positive ethnic choice effects vary over time and across minority generations. The aim of this paper is to fill this gap using large-scale survey data from Switzerland (2000–2016; N = 100,495). Using multilevel analyses, I am able to show that positive ethnic choice effects are persistent over time in Switzerland. Furthermore, it becomes clear that positive ethnic choice effects vary across ethnic minority generations, with these effects decreasing with each succeeding minority generation. Ethnic minority students with one parent born in Switzerland hardly differ from ethnic majority students in their educational decisions.
Spectral variational multi-scale method for parabolic problems: application to 1D transient advection-diffusion equations
Authors: Rebollo Tomás Chacón , Fernández-García Soledad , Moreno-Lopez David , Muñoz Isabel Sánchez 
Published: January 2023

AbstractIn this work, we introduce a variational multi-scale (VMS) method for the numerical approximation of parabolic problems, where sub-grid scales are approximated from the eigenpairs of associated elliptic operator. The abstract method is particularized to the one-dimensional advection-diffusion equations, for which the sub-grid components are exactly calculated in terms of a spectral expansion when the advection velocity is approximated by piecewise constant velocities on the grid elements.We prove error estimates that in particular imply that when Lagrange finite element discretisations in space are used, the spectral VMS method coincides with the exact solution of the implicit Euler semi-discretisation of the advection-diffusion problem at the Lagrange interpolation nodes. We also build a feasible method to solve the evolutive advection-diffusion problems by means of an offline/online strategy with reduced computational complexity.We perform some numerical tests in good agreement with the theoretical expectations, that show an improved accuracy with respect to several stabilised methods.