bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Prediction of Sinonasal Inverted Papilloma‐associated Squamous Cell Carcinoma (IP‐SCC)
Authors: Park Marn Joon , Cho Wonki , Kim Ji Heui , Chung Yoo‐Sam , Jang Yong Ju , Yu Myeong Sang 
Published: January 2023

IntroductionSinonasal inverted papillomas (IP) can undergo transformation into IP‐squamous cell carcinomas (IP‐SCC). More aggressive treatment plan should be established when IP‐SCC is suspected. Nevertheless, inaccuracy of the preoperative punch biopsy results to detect IP‐SCC from IP raises the need for an additional strategy. The present study aimed to investigate significant clinicoradiological remarks associated with IP‐SCC than IP.Material and MethodsPostoperative surgical specimens obtained from patients with confirmed IP or IP‐SCC at a single tertiary medical center from 1997 to 2018 were retrospectively evaluated. Patients' demographic and clinical characteristics, preoperative in‐office punch biopsy results, and preoperative computed tomography (CT) or magnetic resonance images were reviewed. Univariate and multivariate analyses were performed to assess the odds ratio (OR) associated with IP‐SCC. The area under the curve (AUC) in the receiver Operating Characteristic (ROC) curve was calculated in the prediction model to discriminate IP‐SCC from IP.ResultsThe study included 44 IP‐SCC and 301 patients with IP. The diagnostic sensitivity of in‐office punch biopsy to detect IP‐SCC was 70.7%. Multivariate analysis showed that factors significantly associated with IP‐SCC included tobacco smoking >10PY (adjusted‐OR [aOR]: 4.1), epistaxis (aOR: 3.4), facial pain (aOR: 4.2), bony destruction (aOR: 37.6), bony remodeling (aOR: 36.3), and invasion of adjacent structures (aOR: 31.6) (all p < 0.05). Combining all significantly related clinicoradiological features, the ability to discriminate IP‐SCC from IP reached an AUC of 0.974.ConclusionIP patients with a history of tobacco smoking, facial pain, epistaxis, and bony destruction, remodeling, or invasion of an adjacent structure on preoperative images may be at higher risk for IP‐SCC.Level of Evidence3 Laryngoscope, 133:2502–2510, 2023
Short‐term reduction in cropping intensity improves soil quality of topsoil rather than subsoil
Authors: Yao Wei , Liu Qi , Zhou Jie , Wen Yongkang , Tian Butao , Qi Zhiqiang , Yang Yadong , Zeng Zhaohai , Peixoto Leanne , Zang Huadong 
Published: January 2023

AbstractEnhancing cropping intensity is the most effective and significant method to improve regional crop production and ensure food security. However, our understanding of the impacts of reduced cropping intensity on soil quality and ecosystem multifunctionality (EMF) with soil depth remains incomplete in tropical regions. Here, we performed a 4‐year field experiment to estimate the impacts of cropping intensity (continuous cropping, winter fallow, and annual fallow) on soil quality and EMF depending on soil depths. We found that reduced cropping intensity improved soil quality at the topsoil (0–10 cm), while it had no significant influences on soil carbon (C) and nitrogen (N) storage, as well as soil EMF at 0–40 cm. Soil microbes were limited by C and P but not co‐limited by N in all three cropping systems. Reduced cropping intensity exacerbated microbial C limitation at 0–10 cm due to reduced additional C resources (i.e., rice straw and manure) input. Redundancy analysis and Pearson correlation showed that soil N significantly affected the C‐, N‐, and P‐acquisition enzyme activities, and correlated positively with soil organic C, microbial biomass C, and available P. In conclusion, short‐term reduction in cropping intensity improves topsoil quality but not soil EMF under paddy‐upland rotations in the tropical region.
Residual Quantum Effects beyond Mean‐Field Treatment in Quantum Optics Systems
Authors: Huang Yue‐Xun , Li Ming , Chen Zi‐Jie , Zhang Yan‐Lei , Zou Xu‐Bo , Guo Guang‐Can , Zou Chang‐Ling 
Published: January 2023

AbstractMean‐field treatment (MFT) is frequently applied to approximately predict the dynamics of quantum optics systems. It simplifies the system Hamiltonian by neglecting the quantum statistics of certain modes that are driven strongly by lasers or couple weakly with other modes. However, the neglected quantum correlations between different modes result in unanticipated quantum effects and might lead to significantly distinct system dynamics. Here, a general and systematic theoretical framework based on perturbation theory in company with MFT is provided to capture these quantum effects. The form of nonlinear dissipation and parasitic Hamiltonian as well as their relationship to the nonlinear coupling rate are predicted. Furthermore, the indicator is also proposed as a measure of the accuracy of mean‐field treatment. As an example, this theory is applied to quantum frequency conversion, in which mean‐field treatment is commonly applied, to test its limitation under strong pump and large coupling strength. The analytical results show excellent agreement with the numerical simulations. This work clearly reveals the residual quantum effects neglected by MFT and provides a more precise theoretical framework for nonlinear optics and quantum optics.
Reading Alterations in Parkinson's Disease Indicate Worse Cognitive Status
Authors: Tsitsi Panagiota , Nilsson Mattias , Seimyr Gustaf Öqvist , Larsson Olof , Svenningsson Per , Markaki Ioanna 
Published: January 2023

AbstractBackgroundReading difficulties are commonly reported in Parkinson's disease (PD). So far, only a few studies have assessed reading in PD, most of them confirming a different pattern in patients compared with healthy populations. Impaired oculomotor control is an early feature of PD. Cognitive deficits, on the other hand, may appear early, but they are most prominent at later stages. Although these two factors are thought to be responsible for the alterations in reading performance, it is unclear how each factor contributes to them.ObjectivesTo evaluate eye movements during reading in PD and healthy controls (HCs).MethodsData from 42 HCs (36% men) and 48 patients with PD (67% men) at Hoehn and Yahr stages ≤3 were analyzed. PD participants were further divided into 2 groups based on their Montreal Cognitive Assessment (MoCA) score using a cutoff of ≥26. Eye movements were recorded with Tobii Pro Spectrum, a screen‐based eye tracker with a sampling rate of 1200 Hz.ResultsPD participants performed fewer fixations per second (P = 0.033), with a longer mean (P = 0.037) and standard deviation fixation duration (P = 0.033) than HC, and further analysis showed that only patients with a lower MoCA score performed worse than HCs. Reading parameters were weakly associated with MoCA scores, irrespective of age and education.ConclusionChanges in the reading pattern of PD patients are probably attributed to cognitive rather than pure oculomotor alterations.
Dietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut‐Associated Gene Expression, and Microbiome in the Zebrafish Model of IBD
Authors: Novichkova Ekaterina , Nayak Sagar , Boussiba Sammy , Gopas Jacob , Zilberg Dina , Khozin‐Goldberg Inna 
Published: January 2023

ScopeMicroalgae are an emerging nutritional resource of biomolecules with potential to alleviate gut inflammation. The study explores the anti‐inflammatory and immunomodulatory potential of the microalga Lobosphaera incisa P127, which accumulates a rare omega‐6 LC‐PUFA dihomo‐ɣ‐linolenic acid (DGLA) under nitrogen starvation. The therapeutic potential of dietary supplementation with P127 is investigated in the zebrafish model of IBD (TNBS‐induced colitis).Methods and resultsGuts are sampled from zebrafish fed experimental diets for 4 weeks, before and 24 h after TNBS challenge. Diets containing 15% non‐starved (Ns) and 7.5% and 15% N‐starved (St) algal biomass significantly attenuate the severity of gut injury and goblet cell depletion. In contrast, diets containing 7.5% Ns and DGLA ethyl ester have no effect on gut condition. Fish fed 15% St, high‐DGLA biomass, have the fewest individuals with pathological alterations in the gut. Dietary inclusion of Ns and St distinctly modulates gut‐associated expression of the immune and inflammatory genes. Fish fed 15% Ns biomass display a coordinated boost in immune gene expression and show major changes in the gut microbiome prior challenge.ConclusionDietary inclusion of L. incisa biomass at two physiological states, ameliorates TNBS‐induced gut inflammation, suggesting the synergistic beneficial effects of biomass components not limited to DGLA.
The Impact of Zinc on Manganese Bioavailability and Cytotoxicity in HepG2 Cells
Authors: Michaelis Vivien , Kasper Silja , Naperkowski Lisa , Pusse Jan , Thiel Alicia , Ebert Franziska , Aschner Michael , Schwerdtle Tanja , Haase Hajo , Bornhorst Julia 
Published: January 2023

ScopeDespite their essentiality, several studies have shown that either manganese (Mn) or zinc (Zn) overexposure may lead to detrimental health effects. Although Mn is transported by some of the SLC family transporters that translocate Zn, the role of Zn in hepatocellular Mn transport and Mn‐induced toxicity have yet to be fully characterized.Methods and ResultsThe human hepatoma cell line, HepG2, is utilized. Total cellular Mn and Zn amounts are determined after cells are treated with Zn 2 or 24 h prior to Mn incubation for additional 24 h with inductively coupled plasma‐based spectrometry and labile Zn is assessed with the fluorescent probe FluoZin‐3. Furthermore, mRNA expression of genes involved in metal homeostasis, and mechanistic endpoints associated with Mn‐induced cytotoxicity are addressed. These results suggest that Zn protects against Mn‐induced cytotoxicity and impacts Mn bioavailability to a great extent when cells are preincubated with higher Zn concentrations for longer duration as characterized by decreased activation of caspase‐3 as well as lactate dehydrogenase (LDH) release.ConclusionsZn protects against Mn‐induced cytotoxicity in HepG2 cells possibly due to decreased Mn bioavailability. Additionally, mRNA expression of metal homeostasis‐related genes indicates possible underlying pathways that should to be addressed in future studies.
Serial multiple mediation of psychological empowerment and job burnout in the relationship between workplace bullying and turnover intention among Chinese novice nurses
Authors: Ren Liping , Kim Hyunli 
Published: January 2023

AbstractAimThis study aimed to examine the direct and indirect effects of workplace bullying on turnover intention using the serial multiple mediators of psychological empowerment and job burnout.DesignA cross‐sectional study was conducted.MethodsA convenience sample of 506 novice nurses from five Triple A hospitals in China's S province from November 2020 to February 2021 and were evaluated using online questionnaires on workplace bullying, psychological empowerment, job burnout, and turnover intention.ResultsThe prevalence of turnover intention was 51.9%. In the serial multiple mediator model, workplace bullying had a direct effect (c = 0.452, p < 0.001) and indirect effect (c' = 0.229, p < 0.001) on turnover intention through the serial multiple mediators of psychological empowerment (B = −0.093, p = 0.020) and job burnout (B = 0.127, p < 0.001); hence, the proposed model explained the total variance of 32.2% in turnover intention.Patient or public contributionNursing managers should use effective measures for strengthening the psychological empowerment to minimize novice nurse burnout and turnover intention resulting from workplace bullying.
Association between working memory updating ability and cognitive reappraisal: An investigation into a modulatory role of the individual's sex
Authors: Zhao Xin , Cai Yaya , Maes Joseph H. R. 
Published: January 2023

AbstractCognitive reappraisal has been shown to be an effective emotion regulation strategy that contributes to mental health. Previous studies focused on sex differences in the frequency of use and ability to use this strategy, and the association of fequency of use and ability with executive functioning. However, there is a lack of behavioral studies examining whether the involvement of executive functions in cognitive reappraisal use and ability differs for men and women. Such a sex difference may inform the design of cognitive interventions directed at enhancing cognitive reappraisal use and ability. The present study used a sample of 125 Chinese university students and focused on one key component of executive functioning: working memory updating. Frequency of cognitive reappraisal use was assessed by self‐report. Ability to use cognitive reappraisal and working memory updating capacity were each assessed with a laboratory task. The results revealed no sex difference in cognitive reappraisal use or ability. However, of primary interest, the ability to apply cognitive reappraisal was associated with working memory updating performance, but only for women. If confirmed in further studies, these findings suggest that cognitive interventions in general, and working memory updating trainings more specifically, are more likely to enhance the ability to use cognitive reappraisal as a means to regulate emotions in women than in men.
Validation of valence bond and molecular orbital models in analyzing the anionic hyperconjugation effect on the stability of alkyl and fluorinated carbanions in gaseous phase
Authors: Nguyen Lam H. , Pham‐Tran Nguyen‐Nguyen 
Published: January 2023

AbstractIn this paper, the anionic hyperconjugation occurring in alkyl and fluorinated carbanions in the gaseous phase is examined at density functional theory (DFT) at the level of theory B3LYP/6‐31++G (d,p) with empirical dispersion‐GD3 theory. First, a contribution of this study is to confirm that the C‐H bond in (CH3)3C‐H (isobutane) is more acidic than the C‐H bonds in CH3CH2‐H (ethane) and (CH3)2CH‐H (propane) based on a comparison of conjugate base stability. Also, the natural population analysis (NPA) and CHELPG methods are well‐performed for calculating charge distribution on carbon atoms, and in contrast, the Mulliken population is better for hydrogen atoms to describe the anionic hyperconjugation in the valence bond (VB) model. The molecular orbital model accounts for the stability order of alkyl and perfluorinated carbanions through the number, strength, and overlap geometry between the lone electron pair on carbon atom and the vicinal σ*C‐H/σ*C‐F orbitals. On the other hand, the utility of VB theory becomes invalid because of the strong inductive effect of the fluorine element and the steric repulsion among CF3 groups in perfluorinated carbanions. Also, the hybridization of the carbon atom holding the lone electron pair can become more s‐character or p‐character dependent on the size of surrounding groups.
Process safety analysis using operational data and Bayesian network
Authors: Daley James , Khan Faisal , Amin Md. Tanjin 
Published: January 2023

AbstractFault detection and diagnosis (FDD) methods have recently experienced significant advances. These methods provide valuable information from an abnormal situation management perspective. However, traditional FDD methods do not consider system failure analysis, which is required from the process safety perspective. This work seeks to overcome this barrier and presents a methodology to assess process system failure probability based on process operational data and system knowledge. The methodology is built using the principal component analysis (PCA) and a Bayesian network (BN). The PCA is used for FDD, while the BN determines the probability of system failure once a fault is detected. This portion of the network is based on the logical relationship of the data, operational thresholds, and system failure conditions. The proposed methodology is tested and verified on a level‐controlled tank system and the real‐life failure scenario of the 2010 Tesoro heat exchanger explosion. The results suggest that the proposed methodology helps to assess process system failure probability based on process operating conditions. The current work is expected to give a stimulus on digital process safety education.
The diagnostic and prognostic value of growth differentiation factor‐15 in systemic lupus erythematosus‐associated pulmonary arterial hypertension
Authors: Qian Junyan , Ding Yufang , Yang Xiaoxi , Wang Qian , Zhao Jiuliang , Liu Yongtai , Tian Zhuang , Wang Yanhong , Li Mengtao , Zeng Xiaofeng 
Published: January 2023

AbstractGrowth‐differentiation factor (GDF)‐15 is a member of transforming growth factor‐β‐related cytokine and may respond to right ventricular overload. The objective of this article was to assess the diagnosis and prognostic value of GDF‐15 in systemic lupus erythematosus‐associated pulmonary arterial hypertension (SLE‐PAH). Serum samples were obtained from 65 patients with SLE‐PAH, 51 sex and age matched patients of SLE without PAH (SLE‐non‐PAH), and 32 healthy controls. Serum GDF‐15 level was detected by enzyme‐linked immunosorbent assay and the optimal cut‐off point was determined by receiver operating characteristic curve. The primary end‐point was death from any cause and the secondary end‐point was target goal achievement (TGA). Cox regression analyses and Kaplan−Meier method were performed to identify the prognostic value of GDF‐15. Serum GDF‐15 levels were significantly higher in SLE‐PAH patients (1112.14 ± 781.80 pg/mL) than SLE‐non‐PAH patients (810 ± 408 pg/mL) and healthy controls (442 ± 139 pg/mL) at baseline. The optimal cut‐off value of GDF‐15 in the diagnosis of SLE‐PAH was 733 pg/mL (AUC = 0.84). In patients with SLE‐PAH, GDF‐15 level was associated with 6 min walking distance (ρ = −0.385, p = 0.017) and higher serum N terminal‐pro brain natriuretic peptide (NT‐proBNP) (ρ = 0.605, p < 0.001). Patients with GDF‐15 > 733 pg/mL were more likely to death (adjusted hazard ratio [HR] = 4.01, 95% confidence intervals [CI]: 1.23−6.27, p = 0.041) and less likely to achieve treatment goal (adjusted HR = 0.57, 95% CI: 0.23−0.79, p = 0.028). In addition, patients with simultaneous elevation of GDF‐15 and NT‐proBNP showed lower proportion of TGA (p = 0.046). In conclusion, GDF‐15 is a new and promising biomarker of development and prognosis in SLE‐PAH. The combination of GDF‐15 and NT‐proBNP may provide more accurate prognostic information.
Long‐term analysis of persistence and size of swallow and martin roosts in the US Great Lakes
Authors: Belotti Maria Carolina T. D. , Deng Yuting , Zhao Wenlong , Simons Victoria F. , Cheng Zezhou , Perez Gustavo , Tielens Elske , Maji Subhransu , Sheldon Daniel , Kelly Jeffrey F. , Horton Kyle G. 
Published: January 2023

AbstractIn this study, we combined a machine learning pipeline and human supervision to identify and label swallow and martin roost locations on data captured from 2000 to 2020 by 12 Weather Surveillance Radars in the Great Lakes region of the US. We employed radar theory to extract the number of birds in each roost detected by our technique. With these data, we set out to investigate whether roosts formed consistently in the same geographic area over two decades and whether consistency was also predictive of roost size. We used a clustering algorithm to group individual roost locations into 104 high‐density regions and extracted the number of years when each of these regions was used by birds to roost. In addition, we calculated the overall population size and analyzed the daily roost size distributions. Our results support the hypothesis that more persistent roosts are also gathering more birds, but we found that on average, most individuals congregate in roosts of smaller size. Given the concentrations and consistency of roosting of swallows and martins in specific areas throughout the Great Lakes, future changes in these patterns should be monitored because they may have important ecosystem and conservation implications.
Efficient Regulation of Polysulfides by MoS2/MoO3 Heterostructures for High‐Performance Li‐S Batteries
Authors: Cheng Pu , Shi liangliang , Li Wenqi , Fang Xiaorong , Cao Dianliang , Zhao Yonggang , Cao Peng , Liu Dequan , He Deyan 
Published: January 2023

AbstractThe notorious shuttle effect and sluggish conversion of polysulfides seriously hinder the practical application of Lithium‐sulfur (Li‐S) batteries. In this study, a novel architecture of MoS2/MoO3 heterostructure uniformly distributed on carbon nanotubes (MoS2/MoO3@CNT) is designed and introduced into Li‐S batteries via decorating commercial separator to regulate the redox reactions of polysulfides. Systematic experiments and theoretical calculations showed that the heterostructure not only provides sufficient surface affinity to capture polysulfides and acts as an active catalyst to promote the conversion of polysulfides, but also the highly conductive CNT enables rapid electron/ion migration. As a result, Li‐S batteries with the MoS2/MoO3@CNT‐PP separator deliver an impressive reversible capacity (1015 mAh g−1 at 0.2 A g−1 after 100 cycles), excellent rate capacity (873 mAh g−1 at 5 A g−1), and low self‐discharge capacity loss (94.6% capacity retention after 7 days of standing). Moreover, even at an elevated temperature of 70 °C, it still exhibits high‐capacity retention (800 mAh g−1 at 1 A g−1 after 100 cycles). Encouragingly, when the sulfur load is increased to 8.7 mg cm−2, the high reversible areal capacity of 6.61 mAh cm−2 can be stably maintained after 100 cycles, indicating a high potential for practical application.
Single Unit‐Cell Layered Bi2Fe4O9 Nanosheets: Synthesis, Formation Mechanism, and Anisotropic Thermal Expansion
Authors: Liu Yunpeng , Zhong Jiajun , Liu Ziyi , Wen Wen , Sun Bo , Wang Hao , Yao Lei , Chen Zhongjun , Wang Dongqi , Wu Zhonghua 
Published: January 2023

AbstractAs an important multiferroic material, pure and low‐dimensional phase‐stable bismuth ferrite has wide applications. Herein, one‐pot hydrothermal method was used to synthesize bismuth ferrite. Almost pure Bi2Fe4O9, BiFeO3, and their mixture were successfully obtained by controlling the KOH concentration in the hydrothermal solutions. The as‐prepared Bi2Fe4O9 products were crystalline with Pbam space group, had nanosheet morphology, and tended to aggregate into nanofloret or random stacking. Each Bi2Fe4O9 nanosheet was a single crystal with (001) plane as its exposed surface. Single unit‐cell layered Bi2Fe4O9 nanosheets had a uniform thickness of 1 nm. The surface energies of various (100), (010), and (001) planes were 3.6–4.0, 5.6–15.1, and 1.7–3.0 J m−2, respectively, in the Bi2Fe4O9 crystal. The formation mechanism and structural model of the as‐prepared single unit‐cell layered Bi2Fe4O9 nanosheets have been given. The growth of Bi2Fe4O9 nanosheets was discussed. Thermal analysis showed that the Bi2Fe4O9 phase was stable up to 1260 K. The thermal expansion behavior of the Bi2Fe4O9 nanosheet was nonlinear. The thermal expansion coefficients of the ultrathin Bi2Fe4O9 nanosheets on the a‐, b‐, c‐axes, and on the unit‐cell volume V were determined, showing an anisotropic thermal expansion behavior. This study is helpful for the controllable synthesis of ultrathin Bi2Fe4O9 nanosheets.
Chemical vapor deposition for few‐layer two‐dimensional materials
Authors: Zhang Qing , Geng Dechao , Hu Wenping 
Published: January 2023

AbstractChemical vapor deposition (CVD) approach offers a controllable strategy for preparing large‐area and high‐quality few‐layer (mainly bilayer or trilayer) twisted or untwisted two‐dimensional (2D) materials, and is predicted to boost the development of 2D materials from laboratory research to industrial applications.