bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRANSPOSIÇÃO DIDÁTICA: UM OLHAR PARA O ENSINO DA FÍSICA
Authors: Carneiro André Tarcisio , Prado Suzana Pereira do 
Published: May 2023

Este texto discute por meio de uma pesquisa bibliográfica alguns enfoques da Teoria da Transposição Didática (TD), em especial a transposição didática interna e a sobrevivência dos saberes no âmbito do ensino da Física. Buscou-se reconhecer a importância de refletir sobre o processo de construção do saber a ensinar, bem como as adaptações e aproximações estabelecidas pela noosfera. Para tanto, trouxemos uma definição de Transposição Didática em Chevallard e sua abordagem na Física através de Brockington e Pietrocola. Concluímos que é possível a aplicabilidade da TD em contextos para além da Matemática, porém, ainda existem alguns obstáculos referentes ao tempo didático e por vezes em torno da própria noosfera, o que pode impactar no processo de aprendizagem.
Palavras-chave: Transposição Didática. Física. Ensino. Aprendizagem.

ABSTRACT
This text discusses, through a bibliographical research, some approaches of the Didactic Transposition Theory (DT), in particular the internal didactic transposition and the survival of knowledge within the scope of Physics teaching. We sought to recognize the importance of reflecting on the process of building knowledge to teach, as well as the adaptations and approximations established by the noosphere. For that, we brought a definition of Didactic Transposition in Chevallard and its approach in Physics through Brockington and Pietrocola. We conclude that the applicability of DT in contexts beyond the Mathematics, however, there are still some obstacles related to didactic time and sometimes around the noosphere itself, which can impact the learning process.
Keywords: Didactic Transposition. Physical. Teaching. Learning.
RISKS ANALYSIS IN CATERING INDUSTRY
Authors: ANKARALIGİL Tolga , ÖZDEMİR Ayşe 
Published: May 2023

In recent years, the occupational health and safety has become one of the important elements of working life. The importance of contributing to the protection of employee health by preventing occupational accidents and occupational diseases is increasing demand nowadays. The rapid growth of the catering sector with increasing employment and competition turn into a growing problem: increase in occupational accidents. In this research carried out with the necessity of taking precautions for the solution of this problem; A risk analysis was conducted in a catering company in Uşak to identify hazards and risks in the company. The hazards and risks are evaluated and precautionary actions were determined according to the current situation. At the same time, it is thought to be beneficial in terms of creating awareness for all companies in the sector by contributing to the protection of employee health by reducing occupational accidents and diseases. Risk analyses were done by L type matrix (5x5 matrix table). In this study, a total of 131 hazards and risks were identified. The identified hazards and risks are grouped according to their risk level (Unacceptable risk: 5; Significant risk:61; Medium risk:59). It is considered that adopting proactive approaches within the scope of occupational safety practices will accelerate the spread of the safety network and occupational safety culture to all employees
IMMUNOHISTOCHEMICAL ANALYSIS OF SFLT-1 AND ADAMTS-8 EXPRESSION IN DIABETIC RAT TESTIS TISSUE
Authors: KAYA Seval , NERGİZ Yusuf , ASIR Fırat , GÖKALP ÖZKORKMAZ Ebru , ERDOGAN Gamze , DEVECİ Engin 
Published: May 2023

Abstract: The aim of this study was to determine the testicular inflammation
and angiogenetic effect of diabetes with ADAMTS-8 and SFlt-1 proteins
immunohistochemically. Wistar albino male rats (n: 12)were used for the study,
Group 1: Control group (n: 6), only 1 ml i.p. saline injection was performed.
Group 2: Diabetes group (n: 6) received a single intraperitoneal dose of
streptozotocin (STZ) of 60 mg / kg. The glucose value measured above 250 mg /
dl was considered as diabetic. Under anesthesia, dissection was performed at
the lower part of abdominal clearance and testicular tissue was removed. Testis
tissues were fixed in 10% neutral formalin, followed by the routine paraffin
protocol and cut with a microtome. Then, primary antibodies (ADAMTS-8, sFlt-1)
were applied by immunohistochemistry method and incubated at +4 ˚C overnight.
The sections were then examined under a light microscope.

Diabetes
group showed that Leydig cells in the inter tubular area had vacuolization and
capillary dilatations in histopathological examinations. sFlt-1 staining of
control group showed positive expression in capillary endothelium between
Leydig chambers of the intertubular area. Sflt-1 expression of diabetes group
was observed in degenerative spermatic cells and Sertoli cells of the basement
membrane facing tubules. The expression of ADAMTS-8in control group was
positive in some Leydig cells in the interstitial area of Sertoli cells in
seminiferous tubule but, spermatogenetic cells were negative. In the ADAMTS-8
staining of diabetes group, the expression of ADAMTS-8 was increased in the
stromal cells and some inflammatory cells in the intertubular space. SFlt-1 plays a crucial role in angiogenesis
as well as in diabetic testes and is marked as a precursor for the disruption
of vascular structure and blood flow due to degenerative changes. It is thought
that the distribution of ADAMTS-8 may be a determinant protein in the
development of extracellular matrix and in damage to testicular tissue of
diabetic testis.
FENOMENA FLYPAPER EFFECT PADA PENGELOLAAN KEUANGAN DAERAH KABUPATEN DAN KOTA DI JAWA TIMUR
Authors: Linawati  
Published: May 2023

Pemerintah daerah harus melakukan pengelolaan keuangan dengan baik. Diwujudkan dengan melakukan perencanaan penerimaan dan pengeluaran daerah yang efektif dan efisien. Penelitian ini bertujuan untuk menganalisis fenomena flypaper effect pada pengelolaan keuangan daerah Kota dan Kabupaten di Jawa Timur. Pengelolaan diproksikan dengan mengkaji pengaruh PAD dan DAU terhadap belanja daerah. Analisis menggunakan analisis regresi berganda. Hasil penelitian mendapatkan bukti bahwa Pendapatan Asli Daerah dan Dana Alokasi Umum secara parsial maupun simultan berpengaruh signifikan terhadap belanja daerah di Kota dan Kabupaten Di Jawa Timur. Hasil penelitian juga menemukan hasil bahwa tidak terjadi fenomena flypaper Effect pada kota dan kabupaten di Jawa Timur. Hal ini mengungkapkan bahwa pemerintah daerah Kota dan Kabupaten di Jawa timur tidak mengandalkan dana transfer dari pemerintah pusat berupa DAU sebagai sumber pembiayaan untuk belanja daerahnya. Pemerintah daerah Kota dan Kabupaten di Jawa Timur ingin mewujudkan otonomi daerah yang kuat, dengan tingkat kemandirian daerah yang tinggi.
Sistem Informasi Geografis Pemetaan Angka Gizi Buruk di Wilayah Kediri
Authors: Shofi Romal ‘Izzul ‘Ula  , Rinanza Zulmy Alhamri  
Published: May 2023

Proses representasi pemetaan angka gizi buruk di wilayah Kediri belum menggunakan teknologi komputer, sehingga proses pemantauan angka gizi buruk pada setiap wilayah masih belum tersajikan dengan baik. Hal ini tentu mempersulit kerja dari kader maupun dinas Kehatan untuk memantau angka gizi buruk di Wilayah Kediri. Oleh karena itu, perlu dibangun sebuag sistem informasi yang mampu menyediakan data-data baik dalam bentuk grafik maupun peta untuk pemetaan angka gizi buruk di wilayah Kediri. Perancangan dan pembangunan sistem informasi ini dilakukan dengan menggunakan metode pengambilan data dan wawancara langsung kepada Dinas Kesehatan Kota dan Kabupaten Kediri, dengan mencari referensi lain terkait dengan penilitian yang serupa.
Tujuan dibangunnya Sistem Informasi Geografis Pemetaan Angka Gizi buruk di Wilayah Kediri adalah agar dapat membantu masyarakat dan Dinas Kesehatan dalam memantau serta menangani kasus gizi buruk di wilayah Kediri. Sistem Informasi Geografis ini akan menampilkan data gizi buruk berdasarkan kecamatan dengan menggunakan poligon warna sebagai tanda yang memberikan informasi mengenai keadaan yang aman atau keadaan yang membutuhkan penanganan lebih lanjut. Sistem yang dirancang akan diimplementasikan menggunakan framework laravel dengan bahasa pemrogaman yang digunakan adalah PHP, CSS, JavaScript, dan menggunakan database MySQL.
Development and evaluation of pH sensitive semi-interpenetrating networks: assessing the impact of itaconic acid and aloe vera on network swelling and cetirizine release
Authors: Ajaz Nyla , Bukhsh Munnaza , Kamal Yousaf , Rehman Fauzia , Irfan Muhammad , Khalid Syed Haroon , Asghar Sajid , Rizg Waleed Y. , Bukhary Sahar M. , Hosny Khaled M. , Alissa Mohammed , Safhi Awaji Y. , Sabei Fahad Y. , Khan Ikram Ullah 
Published: May 2023

Hydrogels are crosslinked three-dimensional networks, and their properties can be easily tuned to target the various segments of the gastrointestinal tract (GIT). Cetirizine HCl (CTZ HCl) is an antihistaminic drug, which when given orally can upset the stomach. Moreover, this molecule has shown maximum absorption in the intestine. To address these issues, we developed a pH-responsive semi-interpenetrating polymer network (semi-IPN) for the delivery of CTZ HCl to the lower part of the GIT. Initially, 10 different formulations of itaconic acid-grafted-poly (acrylamide)/aloe vera [IA-g-poly (AAm)/aloe vera] semi-IPN were developed by varying the concentration of IA and aloe vera using the free radical polymerization technique. Based on swelling and sol-gel analysis, formulation F5 containing 0.3%w/w aloe vera and 6%w/w IA was chosen as the optimum formulation. The solid-state characterization of the optimized formulation (F5) revealed a successful incorporation of CTZ HCl in semi-IPN without any drug-destabilizing interaction. The in vitro drug release from F5 showed limited release in acidic media followed by a controlled release in the intestinal environment for over 72 h. Furthermore, during the in vivo evaluation, formulation F5 did not affect the hematological parameters, kidney, and liver functions. Clinical observations did not reveal any signs of illness in rabbits treated with hydrogels. Histopathological images of vital organs of treated animals showed normal cellular architecture. Thus, the results suggest a non-toxic nature and overall potential of the developed formulation as a targeted drug carrier.
Mussel-inspired HA@TA-CS/SA biomimetic 3D printed scaffolds with antibacterial activity for bone repair
Authors: Ji Cheng , Zhang Chengcheng , Xu Zeya , Chen Yan , Gan Yanming , Zhou Minghui , Li Lan , Duan Qinying , Huang Tingting , Lin Jinxin 
Published: May 2023

Bacterial infection is a major challenge that could threaten the patient’s life in repairing bone defects with implant materials. Developing functional scaffolds with an intelligent antibacterial function that can be used for bone repair is very important. We constructed a drug delivery (HA@TA-CS/SA) scaffold with curcumin-loaded dendritic mesoporous organic silica nanoparticles (DMON@Cur) via 3D printing for antibacterial bone repair. Inspired by the adhesion mechanism of mussels, the HA@TA-CS/SA scaffold of hydroxyapatite (HA) and chitosan (CS) is bridged by tannic acid (TA), which in turn binds sodium alginate (SA) using electrostatic interactions. The results showed that the HA@TA-CS/SA composite scaffold had better mechanical properties compared with recent literature data, reaching 68.09 MPa. It displayed excellent degradation and mineralization capabilities with strong biocompatibility in vitro. Furthermore, the antibacterial test results indicated that the curcumin-loaded scaffold inhibited S.aureus and E.coli with 99.99% and 96.56% effectiveness, respectively. These findings show that 3D printed curcumin-loaded HA@TA-CS/SA scaffold has considerable promise for bone tissue engineering.
Progression from prediabetes to type 2 diabetes mellitus in adolescents: a real world experience
Authors: Weiner Alyson , Zhang Meng , Ren Sheng , Tchang Beverly , Gandica Rachelle , Murillo Jaime 
Published: May 2023

BackgroundObesity in pediatric patients is strongly associated with increased vascular and metabolic risk. Prediabetes is present in up to 1 in 5 adolescents, aged 12-18 years-old, though is thought to remit spontaneously in a significant portion. Pediatric patients with type 2 diabetes mellitus (T2D) have a more rapid decline of beta-cell function and progression to treatment failure than adult T2D patients. Thus, there is a strong interest in better understanding the natural history of prediabetes in these youth. We aimed to evaluate the real-world rate of progression of prediabetes to T2D in adolescent patients.MethodsThis is a retrospective study of 9,275 adolescent subjects aged 12-21 years-old with at least 3 years of de-identified commercial claims data and a new diagnosis of prediabetes during the observation period. Enrollees with a T2D diagnosis and/or diabetes medication use in the 1 year prior to prediabetes diagnosis or a T2D diagnosis in the 1 month following prediabetes diagnosis were excluded. Enrollees with diagnoses of type 1 diabetes (T1D) or polycystic ovarian syndrome over the 3 years were also excluded. Progression to T2D was defined by claims data of two T2D diagnoses at least 7 days apart, HbA1c ≥ 6.5%, and/or prescription of insulin without known T1D. Enrollees were followed for 2 years after prediabetes diagnosis.ResultsOverall, 232 subjects (2.5%) progressed from prediabetes to T2D. There were no differences found in T2D progression based on sex or age. Progression to T2D occurred at a median of 302 days after prediabetes diagnosis (IQR 123 to 518 days). This study was limited by the lack of laboratory/anthropometric data in administrative claims, as well as the exclusion of 23,825 enrollees for lack of continuous commercial claims data over 3 years.ConclusionIn the largest sample to date on adolescent prediabetes, we found a 2.5% progression of prediabetes to T2D over a median duration of about one year.
Signs and signals limiting myocardial damage using PICSO: a scoping review decoding paradigm shifts toward a new encounter
Authors: Mohl Werner , Kiseleva Zlata , Jusic Alem , Bruckner Matthäus , Mader Robert M. 
Published: May 2023

BackgroundInducing recovery in myocardial ischemia is limited to a timely reopening of infarct vessels and clearing the cardiac microcirculation, but additional molecular factors may impact recovery.ObjectiveIn this scoping review, we identify the paradigm shifts decoding the branching points of experimental and clinical evidence of pressure-controlled intermittent coronary sinus occlusion (PICSO), focusing on myocardial salvage and molecular implications on infarct healing and repair.DesignThe reporting of evidence was structured chronologically, describing the evolution of the concept from mainstream research to core findings dictating a paradigm change. All data reported in this scoping review are based on published data, but new evaluations are also included.ResultsPrevious findings relate hemodynamic PICSO effects clearing reperfused microcirculation to myocardial salvage. The activation of venous endothelium opened a new avenue for understanding PICSO. A flow-sensitive signaling molecule, miR-145-5p, showed a five-fold increase in porcine myocardium subjected to PICSO.Verifying our theory of “embryonic recall,” an upregulation of miR-19b and miR-101 significantly correlates to the time of pressure increase in cardiac veins during PICSO (r2 = 0.90, p &lt; 0.05; r2 = 0.98, p &lt; 0.03), suggesting a flow- and pressure-dependent secretion of signaling molecules into the coronary circulation. Furthermore, cardiomyocyte proliferation by miR-19b and the protective role of miR-101 against remodeling show another potential interaction of PICSO in myocardial healing.ConclusionMolecular signaling during PICSO may contribute to retroperfusion toward deprived myocardium and clearing the reperfused cardiac microcirculation. A burst of specific miRNA reiterating embryonic molecular pathways may play a role in targeting myocardial jeopardy and will be an essential therapeutic contribution in limiting infarcts in recovering patients.
Cardiovascular hemodynamics in mice with tumor necrosis factor receptor—associated factor 2 mediated cytoprotection in the heart
Authors: Marshall Andrea G. , Neikirk Kit , Vue Zer , Beasley Heather K. , Garza-Lopez Edgar , Vang Larry , Barongan Taylor , Evans Zoe , Crabtree Amber , Spencer Elsie , Anudokem Josephs , Parker Remi , Davis Jamaine , Stephens Dominique , Damo Steven , Pham Thuy T. , Gomez Jose A. , Exil Vernat , Dai Dao-fu , Murray Sandra A. , Entman Mark L. , Taffet George E. , Hinton Antentor O. , Reddy Anilkumar K. 
Published: May 2023

IntroductionMany studies in mice have demonstrated that cardiac-specific innate immune signaling pathways can be reprogrammed to modulate inflammation in response to myocardial injury and improve outcomes. While the echocardiography standard parameters of left ventricular (LV) ejection fraction, fractional shortening, end-diastolic diameter, and others are used to assess cardiac function, their dependency on loading conditions somewhat limits their utility in completely reflecting the contractile function and global cardiovascular efficiency of the heart. A true measure of global cardiovascular efficiency should include the interaction between the ventricle and the aorta (ventricular-vascular coupling, VVC) as well as measures of aortic impedance and pulse wave velocity.MethodsWe measured cardiac Doppler velocities, blood pressures, along with VVC, aortic impedance, and pulse wave velocity to evaluate global cardiac function in a mouse model of cardiac-restricted low levels of TRAF2 overexpression that conferred cytoprotection in the heart.ResultsWhile previous studies reported that response to myocardial infarction and reperfusion was improved in the TRAF2 overexpressed mice, we found that TRAF2 mice had significantly lower cardiac systolic velocities and accelerations, diastolic atrial velocity, aortic pressures, rate-pressure product, LV contractility and relaxation, and stroke work when compared to littermate control mice. Also, we found significantly longer aortic ejection time, isovolumic contraction and relaxation times, and significantly higher mitral early/atrial ratio, myocardial performance index, and ventricular vascular coupling in the TRAF2 overexpression mice compared to their littermate controls. We found no significant differences in the aortic impedance and pulse wave velocity.DiscussionWhile the reported tolerance to ischemic insults in TRAF2 overexpression mice may suggest enhanced cardiac reserve, our results indicate diminished cardiac function in these mice.
Thoracic lymphatic anomalies in patients with univentricular hearts: correlation of morphologic findings in isotropic T2-weighted MRI with the outcome after fontan palliation
Authors: Hanser Anja , Hofbeck Michael , Hofmeister Melanie , Martirosian Petros , Hornung Andreas , Esser Michael , Schick Fritz , Kaulitz Renate , Michel Jörg , Nikolaou Konstantin , Schäfer Jürgen , Schlensak Christian , Sieverding Ludger 
Published: May 2023

ObjectivesIn this study we examined the correlation between the extent of thoracic lymphatic anomalies in patients after surgical palliation by total cavopulmonary connection (TCPC) and their outcome in terms of clinical and laboratory parameters.Materials and methodsWe prospectively examined 33 patients after TCPC with an isotropic heavily T2-weighted MRI sequence on a 3.0 T scanner. Examinations were performed after a solid meal, slice thickness of 0.6 mm, TR of 2400 ms, TE of 692 ms, FoV of 460 mm, covering thoracic and abdominal regions. Findings of the lymphatic system were correlated with clinical and laboratory parameters obtained at the annual routine check-up.ResultsEight patients (group 1) showed type 4 lymphatic abnormalities. Twentyfive patients (group 2) presented less severe anomalies (type 1–3). In the treadmill CPET, group 2 reached step 7.0;6.0/8.0 vs. 6.0;3.5/6.8 in group 1 (p = 0.006*) and a distance of 775;638/854 m vs. 513;315/661 m (p = 0.006*). In the laboratory examinations, group 2 showed significantly lower levels of AST, ALT and stool calprotectin as compared to group 1. There were no significant differences in NT-pro-BNP, total protein, IgG, lymphocytes or platelets, but trends. A history of ascites showed 5/8 patients in group 1 vs. 4/25 patients in group 2 (p = 0.02*), PLE occurred in 4/8 patient in group 1 vs. 1/25 patients in group 2 (p = 0.008*).ConclusionIn the long-term follow-up after TCPC, patients with severe thoracic and cervical lymphatic abnormalities showed restrictions in exercise capacity, higher liver enzymes and an increased rate of symptoms of imminent Fontan-failure such as ascites and PLE.
The impact of tumor characteristics on cardiovascular disease death in breast cancer patients with CT or RT: a population-based study
Authors: Chi Kaiyi , Luo Zehao , Zhao Hongjun , Li Yemin , Liang Yinglan , Xiao Zhaoling , He Yiru , Zhang Hanbin , Ma Zaiying , Zeng Liangjia , Zhou Ruoyun , Feng Manting , Li Wangen , Rao Huying , Yi Min 
Published: May 2023

BackgroundPrevious studies focused on the impact of cardiovascular diseases (CVD) risk factors in breast cancer patients with chemotherapy (CT) or radiotherapy (RT). This study aimed to identify the impact of tumor characteristics on CVD death in these patients.MethodsData of female breast cancer patients with CT or RT between 2004 and 2016 were included. The risk factors of CVD death were identified using Cox regression analyses. A nomogram was constructed to evaluate the predicted value of tumor characteristics, and then validated by the concordance indexes (C-index) and calibration curves.ResultA total of 28,539 patients were included with an average follow-up of 6.1 years. Tumor size &gt; 45 mm (adjusted HR = 1.431, 95% CI = 1.116–1.836, P = 0.005), regional (adjusted HR = 1.278, 95% CI = 1.048–1.560, P = 0.015) and distant stage (adjusted HR = 2.240, 95% CI = 1.444–3.474, P &lt; 0.001) were risk factors of CVD death for breast cancer patients with CT or RT. The prediction nomogram of tumor characteristics (tumor size and stage) on CVD survival was established. The C-index of internal and external validation were 0.780 (95% Cl = 0.751–0.809), and 0.809 (95% Cl = 0.768–0.850), respectively. The calibration curves showed consistency between the actual observation and nomogram. The risk stratification was also significant distinction (P &lt; 0.05).ConclusionTumor size and stage were related to the risk of CVD death for breast cancer patients with CT or RT. The management of CVD death risk in breast cancer patients with CT or RT should focus not only on CVD risk factors but also on tumor size and stage.