bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral orchitis‐epididymitis and diffuse periorchitis in a dog due to β‐haemolytic streptococcal infection
Authors: Fuchs Kárita da Mata , de Sousa Gabriela Carneiro , Denadai Renan , de Souza Fabiana Ferreira , de Meira Cezinande 
Published: June 2023

AbstractEpididymitis can be associated with orchitis and periorchitis, and can be classified as acute or chronic, and of an infectious or non‐infectious aetiology. This study aims to describe a case of orchitis‐epididymitis and diffuse periorchitis due to β‐haemolytic streptococcal infection. The dog presented at the veterinary service with an enlarged, hyperaemic scrotum with regional acute pain, lethargy and hyporexia. In the ultrasound exam, an abnormal amount of peritesticular anechoic fluid and enlargement of the left epididymis was observed. Treatment consisted of a bilateral orchiectomy and scrotal ablation. The histopathological exam indicated left orchitis‐epididymitis and diffuse periorchitis, with neutrophilic inflammatory cell infiltrate and the presence of coccoid bacteria. The microbiological exam isolated β‐haemolytic streptococci. Bilateral orchiectomy and the use of a specific antimicrobial was effective in treating the condition.
Performance Evaluation of Patch Repairs on Historic Concrete Structures (PEPS): An Overview of the Project Methodology
Authors: Wilkie Simeon , Goncalves Ana Paula Arato , Macdonald Susan , Marie-Victoire Elisabeth , Bouichou Myriam , Ducasse-Lapeyrusse Jean , Lauder Nicki , Farrell David , Gaudette Paul , Harrer Ann 
Published: June 2023

AbstractThe development of reinforced concrete through the 20th century has resulted in a wealth of culturally significant concrete structures around the world. However, as a relatively modern material durability issues were not fully understood at the time of construction, and many of these structures require ongoing interventions as a result. While there is now a general acceptance of the importance of concrete heritage from this era, there few widely accepted guidelines on the approach to its preservation and conservation. In particular, despite many studies and published guidance on concrete repair and the performance of concrete repairs, there are few on the long-term performance of patch repairs designed to match the aesthetic of the original while simultaneously keeping loss of the original fabric to a minimum. As a response to this challenge, three institutions, the Getty Conservation Institute (GCI), Historic England (HE) and Laboratoire de Recherche des Monuments Historiques (LRMH) are collaborating on The Performance Evaluation of Patch Repairs on Historic Concrete Structures (PEPS) to produce practical guidance that will help those repairing historic concrete. This paper provides an overview of the assessment methodology that has been developed as part of this international collaboration.
Einleitung: Post-digitales Management
Authors: Baecker Dirk , Elsholz Uwe , Locher Maximilian , Thomas Martina 
Published: June 2023

ZusammenfassungPost-digitales Management ist das Management der Einbettung digitaler Datenverarbeitung in analoge Prozesse. Die Einleitung erläutert die Fragestellung des Bandes und führt in die einzelnen Beiträge ein. Im Mittelpunkt steht die Entdeckung der Organisation als soziales System, die ausgerechnet dann auffällt, wenn man glaubt, es nur noch mit technischen Fragestellungen zu tun zu haben. Digitalisierung, so stellt sich heraus, kann nur vom Betrieb im Betrieb vorgenommen werden und erfordert die versammelte Intelligenz von Belegschaft, Management und Geschäftsführung. Die Einleitung erläutert wesentliche Begriffe der folgenden Untersuchungen und unterstreicht einige Ergebnisse. Sie arbeitet mit der Unterscheidung von Mensch, Technik, Organisation und Gesellschaft, ohne zu wissen, wie lange diese Unterscheidung noch Gültigkeit haben wird.
Wozu Akzeptanz? Eine Skizze
Authors: Locher Maximilian 
Published: June 2023

Zusammenfassung
Das Thema Akzeptanz wird auffälligerweise immer dann thematisiert, wenn man es als unattraktiv ansieht, die Nutzung von Technik und die erfolgreiche Kommunikation und Übertragung von Entscheidungen mit hierarchischer Macht durchzusetzen. Die Gründe hierfür sind vielfältig. Statt nach der Einführung neuer Techniken akzeptanzförderliche Maßnahmen aufzunehmen, bewährt es sich, bei der Entwicklung und Implementierung neuer Techniken der Digitalisierung deren schlussendliche Anwender einzubeziehen, um die Technik an deren Arbeitssituationen auszurichten. Die Frage nach der Akzeptanz erweist sich somit als ein Schlüssel zur Thematisierung betrieblicher und sozialer Prozesse und deren wechselseitige Abstimmung.
Digitalisierung als Mittler zwischen Konstruktion und Kantbank: Auswirkungen auf Arbeit und Kompetenzanforderungen
Authors: Thomas Martina , Elsholz Uwe , Neumann René , Henning Tom 
Published: June 2023

ZusammenfassungDie hier vorgestellte Fallskizze beschäftigt sich mit Digitalisierungsvorhaben in einem mittelständischen Betrieb, bei deren Umsetzung jeweils Tätigkeitsanteile automatisiert werden, ohne dass damit jedoch eine Substitution von Arbeitskräften angestrebt wird. Dabei werden die Verschiebungen von Kompetenzanforderungen an die Beschäftigten in den Blick genommen. Es wird deutlich, dass mit der hier fokussierten Digitalisierungsform der Automatisierung von Tätigkeitsanteilen gleichsam Tendenzen zu einer Aufwertung wie auch zu einer Abwertung von Kompetenzprofilen einhergehen können.
Die Idee der schnittstellenübergreifenden Digitalisierung bei MultiProfil
Authors: Mathmann Andreas 
Published: June 2023

ZusammenfassungIn seinem Praxisbericht erläutert Andreas Mathmann, Projektleiter des mittelständischen Unternehmens MultiProfil GmbH & Co. KG, Idee und Umsetzung einer schnittstellenübergreifenden Digitalisierung. Diese verknüpft sowohl verschiedene technische Systeme als auch unterschiedliche Unternehmensbereiche miteinander, um eine transparente und sichere Auftragsabwicklung zu gewährleisten.
Asymptotically nonlocal gravity
Authors: Boos Jens , Carone Christopher D. 
Published: June 2023

AbstractAsymptotically nonlocal field theories interpolate between Lee-Wick theories with multiple propagator poles, and ghost-free nonlocal theories. Previous work on asymp- totically nonlocal scalar, Abelian, and non-Abelian gauge theories has demonstrated the existence of an emergent regulator scale that is hierarchically smaller than the lightest Lee-Wick partner, in a limit where the Lee-Wick spectrum becomes dense and decoupled. We generalize this construction to linearized gravity, and demonstrate the emergent regula- tor scale in three examples: by studying the resolution of the singularity (i) at the origin in the classical solution for the metric of a point particle, and (ii) in the nonrelativistic gravitational potential computed via a one-graviton exchange amplitude; (iii) we also show how this derived scale regulates the one-loop graviton contribution to the self energy of a real scalar field. We comment briefly on the generalization of our approach to the full, nonlinear theory of gravity.
Large primordial fluctuations in gravitational waves from phase transitions
Authors: Bodas Arushi , Sundrum Raman 
Published: June 2023

Abstract
It is well-known that first-order phase transitions in the early universe can be a powerful source of observable stochastic gravitational wave backgrounds. Any such gravitational wave background must exhibit large-scale anisotropies at least as large as those seen in the CMB 10−5, providing a valuable new window onto the (inflationary) origins of primordial fluctuations. While significantly larger fractional anisotropies are possible (for example, in multi-field inflation) and would be easier to interpret, it has been argued that these can only be consistent with CMB bounds if the gravitational wave signal is correspondingly smaller. In this paper, we show that this argument, which relies on assuming radiation dominance of the very early universe, can be evaded if there is an era of early matter dominance of a certain robust type. This allows large gravitational wave anisotropies to be consistent with observable signals at proposed future gravitational wave detectors. Constraints from the CMB on large scales, as well as primordial black hole and mini-cluster formation on small scales, and secondary scalar-induced gravitational waves are all taken into account.
Light-cone sum rules for S-wave B → Kπ form factors
Authors: Descotes-Genon Sébastien , Khodjamirian Alexander , Virto Javier , Vos K. Keri 
Published: June 2023

Abstract
We derive a set of light-cone sum rules relating the S-wave B → Kπ hadronic form factors to the B-meson light-cone distribution amplitudes (LCDAs), taking into account the complete set of LCDAs up to and including twist four. These results complement the sum rules for the P-wave B → Kπ form factors obtained earlier. We then use the new sum rules to estimate the S-wave contributions to B → Kπℓℓ decays as a function of the Kπ invariant mass. We pay particular attention to the fact that the S-wave Kπ spectrum cannot be modelled by a sum of Breit-Wigner resonances, and employ a more consistent dispersive coupled-channel approach. We compare our predictions for branching ratios and angular observables with LHCb measurements in two different kinematic regions, around K∗(892) and $$ {K}_0^{\ast }(1430) $$

K
0
∗

1430

. We observe an overall compatibility and discuss possible improvements of our model to obtain a better description of the B → Kπ form factors over a large kinematic range.
Intracranial Spotty Calcium Predicts Recurrent Stroke in Patients with Symptomatic Intracranial Atherosclerotic Stenosis
Authors: Li Rui , Liu Moqi , Li Jialu , Jiao Xueqiao , Guo Xiuhai 
Published: June 2023

Abstract
Purpose
Accumulating evidence highlights the association of calcium characteristics and cardiovascular events, but its role in cerebrovascular stenosis has not been well studied. We aimed to investigate the contribution of calcium patterns and density to recurrent ischemic stroke in patients with symptomatic intracranial atherosclerotic stenosis (ICAS).

Methods
In this prospective study, 155 patients with symptomatic ICAS in the anterior circulation were included, and all subjects underwent computed tomography angiography. The median follow-up for all patients was 22 months and recurrent ischemic stroke were recorded. Cox regression analysis was performed to examine whether calcium patterns and density were associated with recurrent ischemic stroke.

Results
During the follow-up, 29 patients who experienced recurrent ischemic stroke were older than those without recurrent ischemic stroke (62.93 ± 8.10 years vs. 57.00 ± 12.07 years, p = 0.027). A significantly higher prevalence of intracranial spotty calcium (86.2% vs. 40.5%, p < 0.001) and very low-density intracranial calcium (72.4% vs. 37.3%, p = 0.001) were observed in patients with recurrent ischemic stroke. Multivariable Cox regression analysis showed that intracranial spotty calcium, rather than very low-density intracranial calcium, remained an independent predictor of recurrent ischemic stroke (adjusted hazard ratio 5.35, 95% confidence interval 1.32–21.69, p = 0.019).

Conclusion
In patients with symptomatic ICAS, intracranial spotty calcium is an independent predictor of recurrent ischemic stroke, which will further facilitate risk stratification and suggest that more aggressive treatment should be considered for these patients.
PraeKids: Diagnoseprävalenz lebensbedrohlicher und lebensverkürzender Erkrankungen bei Kindern und Jugendlichen in Deutschland
Authors: Burgio Nadja Melina , Jennessen Sven 
Published: June 2023

Zusammenfassung
Einleitung
In Deutschland wird bis dato von einer Prävalenz von ca. 50.000 Kindern und Jugendlichen ausgegangen, die mit lebensbedrohlichen und lebensverkürzenden Erkrankungen leben. Diese in der Versorgungslandschaft kommunizierte Zahl beruht auf einer Übertragung empirischer Daten aus England.

Methoden
In Zusammenarbeit mit dem Spitzenverband Bund der Krankenkassen (GKV-SV) und dem Institut für angewandte Gesundheitsforschung Berlin GmbH (InGef) wurden die Abrechnungsdaten der von den gesetzlichen Krankenkassen dokumentierten spezifischen Behandlungsdiagnosen der Jahre 2014–2019 analysiert und erstmals Prävalenzdaten von Betroffenen im Alter von 0–19 Jahren erhoben. Zudem wurden mittels der Daten von InGef die Prävalenzwerte nach Diagnosegruppierung, den Together-for-Short-Lives(TfSL)-Gruppen 1–4, und auf Grundlage der in den englischen Prävalenzstudien verwendeten (und hier aktualisierten) Kodierungsliste berechnet.

Ergebnisse
Die Datenanalyse ermöglichte die Festlegung eines Prävalenzbereichs von 319.948 (InGef – adaptierte Fraser-Liste) bis 402.058 (GKV-SV) unter Berücksichtigung der TfSL-Gruppen. Die TfSL-1-Gruppe stellt mit 190.865 Erkrankten die größte Gruppe dar.

Diskussion und Fazit
Erstmalig liegen durch diese Untersuchung für Deutschland Prävalenzwerte von 0‑ bis 19-Jährigen mit lebensbedrohlichen und lebensverkürzenden Diagnosen vor. Da sich im Forschungsdesign die Falldefinitionen und die einbezogenen Versorgungssettings (ambulant/stationär) unterscheiden, differieren die aus den Daten des GKV-SV und des InGef erhobenen Prävalenzwerte. Aufgrund der sehr heterogenen Krankheitsverläufe, Überlebenschancen und Mortalitätsraten können keine unmittelbaren Ableitungen auf palliative und hospizliche Versorgungsstrukturen getroffen werden.
Sparse sensor reconstruction of vortex-impinged airfoil wake with machine learning
Authors: Zhong Yonghong , Fukami Kai , An Byungjin , Taira Kunihiko 
Published: June 2023

Abstract
Reconstruction of unsteady vortical flow fields from limited sensor measurements is challenging. We develop machine learning methods to reconstruct flow features from sparse sensor measurements during transient vortex–airfoil wake interaction using only a limited amount of training data. The present machine learning models accurately reconstruct the aerodynamic force coefficients, pressure distributions over airfoil surface, and two-dimensional vorticity field for a variety of untrained cases. Multi-layer perceptron is used for estimating aerodynamic forces and pressure profiles over the surface, establishing a nonlinear model between the pressure sensor measurements and the output variables. A combination of multi-layer perceptron with convolutional neural network is utilized to reconstruct the vortical wake. Furthermore, the use of transfer learning and long short-term memory algorithm combined in the training models greatly improves the reconstruction of transient wakes by embedding the dynamics. The present machine-learning methods are able to estimate the transient flow features while exhibiting robustness against noisy sensor measurements. Finally, appropriate sensor locations over different time periods are assessed for accurately estimating the wakes. The present study offers insights into the dynamics of vortex–airfoil interaction and the development of data-driven flow estimation.

Graphic abstract
Evaluation of chronic ankle instability and subtalar instability using the angle between the anterior talofibular ligament and calcaneofibular ligament
Authors: Kim Jiyoun , Kim Gab Lae , Kim Taeho , Cho Junghyun 
Published: June 2023

AbstractPurposeA series of studies have reported a change in the length or thickness of the anterior talofibular (ATFL) and calcaneofibular (CFL) ligaments in patients with chronic ankle instability. However, no study has examined the changes in the angle between the ATFL and CFL in patients diagnosed with chronic ankle instability. Therefore, this study analyzed the change in the angle between the ATFL and CFL in patients diagnosed with chronic ankle instability to confirm its relevance.
MethodsThis retrospective study included 60 patients who had undergone surgery for chronic ankle instability. Stress radiographs comprising the anterior drawer test, varus stress test, Broden’s view stress test, and magnetic resonance imaging (MRI) were performed in all patients. The angle between the ATFL and CFL was measured by indicating the vector at the attachment site, as seen on the sagittal plane. Three groups were classified according to the angle between the two ligaments measured by MRI: group I when the angle was > 90°, Group II when the angle was 71–90°, and Group III when the angle was ≤ 70°. The accompanying injuries to the subtalar joint ligament were analyzed via MRI.
ResultsA comparison of the angles between the ATFL and CFL measured on MRI in Group I, Group II, and Group III with the angles measured in the operating room revealed a significant correlation. Broden’s view stress test revealed a statistically significant difference among the three groups (p < 0.05). The accompanying subtalar joint ligament injuries differed significantly among the three groups (p < 0.05).
ConclusionThe ATFL–CFL angle in patients with ankle instability is smaller than the average angle in ordinary people. Therefore, the ATFL–CFL angle might be a reliable and representative measurement tool to assess chronic ankle instability, and subtalar joint instability should be considered if the ATFL–CFL angle is 70° or less.Level of evidenceLevel III.
Detection-only versus detection and identification of model misspecifications
Authors: Zaminpardaz Safoora , Teunissen Peter J. G. 
Published: June 2023

AbstractIt is common practice to use the well-known concept of the minimal detectable bias (MDB) to assess the performance of statistical testing procedures. However, such procedures are usually applied to a null and a set of multiple alternative hypotheses with the aim of selecting the most likely one. Therefore, in the DIA method for the detection, identification and adaptation of model misspecifications, rejection of the null hypothesis is followed by identification of the potential source of the model misspecification. With identification included, the MDBs do not truly reflect the capability of the testing procedure and should therefore be replaced by the minimal identifiable bias (MIB). In this contribution, we analyse the MDB and the MIB, highlight their differences, and describe their impact on the nonlinear DIA-estimator of the model parameters. As the DIA-estimator inherits all the probabilistic properties of the testing procedure, the differences in the MDB and MIB propagation will also reveal the different consequences a detection-only approach has versus a detection+identification approach. Numerical algorithms are presented for computing the MDB and the MIB and also their effect on the DIA-estimator. These algorithms are then applied to a number of examples so as to analyse and illustrate the different concepts.
A review of the current state of single-cell proteomics and future perspective
Authors: Ahmad Rushdy , Budnik Bogdan 
Published: June 2023

AbstractSingle-cell methodologies and technologies have started a revolution in biology which until recently has primarily been limited to deep sequencing and imaging modalities. With the advent and subsequent torrid development of single-cell proteomics over the last 5 years, despite the fact that proteins cannot be amplified like transcripts, it has now become abundantly clear that it is a worthy complement to single-cell transcriptomics. In this review, we engage in an assessment of the current state of the art of single-cell proteomics including workflow, sample preparation techniques, instrumentation, and biological applications. We investigate the challenges associated with working with very small sample volumes and the acute need for robust statistical methods for data interpretation. We delve into what we believe is a promising future for biological research at single-cell resolution and highlight some of the exciting discoveries that already have been made using single-cell proteomics, including the identification of rare cell types, characterization of cellular heterogeneity, and investigation of signaling pathways and disease mechanisms. Finally, we acknowledge that there are a number of outstanding and pressing problems that the scientific community vested in advancing this technology needs to resolve. Of prime importance is the need to set standards so that this technology becomes widely accessible allowing novel discoveries to be easily verifiable. We conclude with a plea to solve these problems rapidly so that single-cell proteomics can be part of a robust, high-throughput, and scalable single-cell multi-omics platform that can be ubiquitously applied to elucidating deep biological insights into the diagnosis and treatment of all diseases that afflict us.
Alheiras with animal fat replacement: application of a gelled emulsion based on hemp oil (Cannabis sativa L.) and buckwheat
Authors: Botella-Martínez Carmen , Fernández-López Juana , Ferreira Iasmin , Leite Ana , Vasconcelos Lia , Domínguez Rubén , Pérez-Álvarez José Ángel , Teixeira Alfredo , Viuda-Martos Manuel 
Published: June 2023

AbstractA gelled emulsion elaborated using hemp seed oil and buckwheat flour was utilized as pork backfat substitute in a typical Portuguese meat product named Alheira. Three different formulations were prepared: Alheiras control (AC) with a fat content of 13%, alheiras where the 25% pork backfat was substituted with a hemp seed oil-GE (AH25), and alheiras where the 50% pork backfat was substituted with a hemp seed oil-GE (AH50). The chemical composition as well as the physicochemical properties and lipid stability of different samples were assessed. Reformulated samples showed similar protein, moisture, and fat content (p < 0.05) that AC. However, AH25 and AH50 had a higher amount of linoleic acid (16.29 and 22.14 g/100 g, respectively) and linolenic acid (1.75 and 3.45 g/100 g, respectively) than AC (12.71 and 0.51 g/100 g). Similarly, AH25 and AH50 showed lower saturated fatty acids (35.28 and 30.37 g/100 g, respectively) than AC (37.37 g/100 g). The substitution of pork backfat for hemp seed oil-GE did not modify significantly the physicochemical properties of samples. On the other hand, the lipid oxidation values increased by 30 and 65% in AH25 and AH50 respectively, in comparison to AC due to the use of polyunsaturated oils, which are highly susceptible to oxidation. This work established that the use of gelled emulsions elaborated using hemp oil and buckwheat flour may be a promising strategy to obtain meat products with a better healthier profile.
Myeloid sarcoma: more and less than a distinct entity
Authors: Loscocco Giuseppe G. , Vannucchi Alessandro M. 
Published: June 2023

AbstractMyeloid sarcoma (MS) is a distinct entity among myeloid neoplasms defined as a tumour mass of myeloid blasts occurring at an anatomical site other than the bone marrow, in most cases concomitant with acute myeloid leukaemia (AML), rarely without bone marrow involvement. MS may also represent the blast phase of chronic myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). However, the clinical and molecular heterogeneity of AML, as highlighted by the 2022 World Health Organization (WHO) and International Consensus (ICC) classifications, indirectly define MS more as a set of heterogeneous and proteiform diseases, rather than a homogeneous single entity. Diagnosis is challenging and relies mainly on histopathology, immunohistochemistry, and imaging. Molecular and cytogenetic analysis of MS tissue, particularly in isolated cases, should be performed to refine the diagnosis, and thus assign prognosis guiding treatment decisions. If feasible, systemic therapies used in AML remission induction should be employed, even in isolated MS. Role and type of consolidation therapy are not univocally acknowledged, and systemic therapies, radiotherapy, or allogeneic hematopoietic stem cell transplantation (allo-HSCT) should be considered. In the present review, we discuss recent information on MS, focusing on diagnosis, molecular findings, and treatments also considering targetable mutations by recently approved AML drugs.