bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the validity of retrospective predictive performance evaluation procedures in just-in-time software defect prediction
Authors: Song Liyan , Minku Leandro L. , Yao Xin 
Published: September 2023

AbstractJust-In-Time Software Defect Prediction (JIT-SDP) is concerned with predicting whether software changes are defect-inducing or clean. It operates in scenarios where labels of software changes arrive over time with delay, which in part corresponds to the time we wait to label software changes as clean (waiting time). However, clean labels decided based on waiting time may be different from the true labels of software changes, i.e., there may be label noise. This typically overlooked issue has recently been shown to affect the validity of continuous performance evaluation procedures used to monitor the predictive performance of JIT-SDP models during the software development process. It is still unknown whether this issue could potentially also affect evaluation procedures that rely on retrospective collection of software changes such as those adopted in JIT-SDP research studies, affecting the validity of the conclusions of a large body of existing work. We conduct the first investigation of the extent with which the choice of waiting time and its corresponding label noise would affect the validity of retrospective performance evaluation procedures. Based on 13 GitHub projects, we found that the choice of waiting time did not have a significant impact on the validity and that even small waiting times resulted in high validity. Therefore, (1) the estimated predictive performances in JIT-SDP studies are likely reliable in view of different waiting times, and (2) future studies can make use of not only larger (5k+ software changes), but also smaller (1k software changes) projects for evaluating performance of JIT-SDP models.
A user study for evaluation of formal verification results and their explanation at Bosch
Authors: Kaleeswaran Arut Prakash , Nordmann Arne , Vogel Thomas , Grunske Lars 
Published: September 2023

Abstract
Context
Ensuring safety for any sophisticated system is getting more complex due to the rising number of features and functionalities. This calls for formal methods to entrust confidence in such systems. Nevertheless, using formal methods in industry is demanding because of their lack of usability and the difficulty of understanding verification results.

Objective
We evaluate the acceptance of formal methods by Bosch automotive engineers, particularly whether the difficulty of understanding verification results can be reduced.

Method
We perform two different exploratory studies. First, we conduct a user survey to explore challenges in identifying inconsistent specifications and using formal methods by Bosch automotive engineers. Second, we perform a one-group pretest-posttest experiment to collect impressions from Bosch engineers familiar with formal methods to evaluate whether understanding verification results is simplified by our counterexample explanation approach.

Results
The results from the user survey indicate that identifying refinement inconsistencies, understanding formal notations, and interpreting verification results are challenging. Nevertheless, engineers are still interested in using formal methods in real-world development processes because it could reduce the manual effort for verification. Additionally, they also believe formal methods could make the system safer. Furthermore, the one-group pretest-posttest experiment results indicate that engineers are more comfortable understanding the counterexample explanation than the raw model checker output.

Limitations
The main limitation of this study is the generalizability beyond the target group of Bosch automotive engineers.
Efficacy of allogenous fascia lata grafts in the management of lower eyelid retraction
Authors: Prinz Julia , Hartmann Kathi , Migliorini Filippo , Hamesch Karim , Walter Peter , Fuest Matthias , Kuerten David 
Published: September 2023

Abstract
Purpose
To report on the use of allogenous fascia lata (FL) grafts in patients with lower eyelid retraction (LER).

Methods
In this retrospective study, a consecutive series of 27 patients (39 eyes) with LER who underwent lower eyelid elevation with FL was included. Examinations including measurement of the palpebral fissure vertical height (PFVH), the inferior scleral show distance, the margin reflex distance 2 (MRD 2), and the evaluation of conjunctival hyperemia were conducted at baseline and after a mean postoperative time of 25.9 ± 25.5 (5.0–81.0, median 13.0, last follow-up) months in all patients.

Results
At the last follow-up, a significant reduction of the PFVH (11.3 ± 1.7 versus 12.8 ± 2.1 at baseline, p < 0.001), the inferior scleral show distance (0.7 ± 1.0 mm versus 2.1 ± 1.1 at baseline, p < 0.001), and the MRD 2 (6.4 ± 0.9 versus 7.8 ± 1.3 at baseline, p < 0.001) occurred. The conjunctival hyperemia grading score (McMonnies) was significantly reduced (1.8 ± 0.7) at the last follow-up compared to baseline (2.6 ± 0.6, p < 0.001). No case of ectropion or entropion was observed at the last follow-up visit.

Conclusion
In this case series, lower eyelid elevation with FL grafts as a spacer led to a significant reduction of the PFVH, MRD 2, inferior scleral show distance, and conjunctival hyperemia. No severe surgery-related complications occurred.
Preliminary assessment of portable sleep monitoring for diagnosis of obstructive sleep apnea in children
Authors: Xian Zhi-xiong , Wang Xin , Chen Yong-chao , Teng Yi-shu 
Published: September 2023

Abstract
Objective
By observing the differences in sleep parameters between portable sleep monitoring (PM) and polysomnography (PSG) in children, we aimed to investigate the diagnostic value and feasibility of PM in children with suspected obstructive sleep apnea (OSA).

Study design
This prospective study enrolled consecutive children (aged 3–14 years) with suspected OSA in Shenzhen Children’s Hospital. They had PSG and PM in the sleep laboratory. Clinical parameters of the two sleep monitoring methods were compared.

Results
A total of 58 children participated. They were classified into two groups according to age: 28 children aged 3 to 5 years and 30 children aged 6 to 14 years. No significant differences were observed in apnea-hypopnea index (AHI), lowest oxygen saturation (LSaO2), and mean oxygen saturation (MSaO2) between PM and PSG, but the sleep efficiency with PM was significantly higher (3–5 years age: 92.2 ± 11.3% vs 85.2 ± 14.3%, 6–14 years age: 93.2 ± 14.5% vs 84.8 ± 16.3%, both P < 0.05) than the sleep efficiency with PSG. Pearson correlation analysis indicated a strong correlation between AHI, LSaO2, MSaO2, and sleep efficiency measured by PSG and PM. Receiver operating characteristic curve (ROC) analysis showed that PM was a reliable diagnostic tool for OSA. PM has high sensitivity (3–5 years age: 95.8%, 6–14 years age: 96.3%) and low specificity (3–5 years age: 25.0%, 6–14 years age: 33.3%) for OSA in children. Thus, there is a low rate of missed diagnoses, but there is some inaccuracy in excluding children who do not have OSA.

Conclusion
The results showed that PM has a good correlation with the various parameters of PSG. PM may be a reliable tool for diagnosing moderate and severe OSA in children, especially those who cannot cooperate with PSG or who have limited access to PSG.
A new fractional Cattaneo model for enhancing the thermal performance of photovoltaic panels using heat spreader: energy, exergy, economic and enviroeconomic (4E) analysis
Authors: El-Gazar Eman F. , Hassan Hamdy , Rabia Sherif I. , Hu Changhong , Zahra Waheed K. 
Published: September 2023

Abstract A new fractional non-Fourier (Cattaneo) photovoltaic (PV) model is presented to enhance the thermal performance of a PV system combined with a heat spreader (HS). The fractional Cattaneo model is shown to be effective in examining transient processes across the entirety of a PV system, in contrast to the conventional Fourier model’s inability to predict system performance. Consequently, a comparison is conducted between the classical Fourier model with the fractional Fourier and fractional Cattaneo models for the PV system. The impact of using an aluminum heat spreader, with rectangular and trapezoidal shapes, has been developed under hot and cold climate conditions. The findings show that adding a trapezoidal heat spreader reduced the cell temperature by 20 K in summer and 12 K in winter. The reduction in the PV temperature led to an enhancement in daily average power by approximately 28% and 37% in hot and cold weather, respectively. Moreover, economic, exergoeconomic, and enviroeconomic assessment is introduced. The outcomes revealed that the electrical production costs of the rectangular and trapezoidal HS systems are 0.272 and 0.214 $/kWh, respectively, while about 0.286 $/kWh for the conventional PV panel. Based on the environmental study, the estimated CO2 reduction for PV, PV with rectangular HS, and PV with trapezoidal spreader is 0.5504, 0.7704, and 0.8012 tons, respectively. Finally, real experimental data are used to validate the fractional Cattaneo model. The results demonstrate that there is a great fitting with the measured data, with errors in PV power and exergy efficiency of just 0.628% and 3.84%, respectively, whereas their corresponding values for the classical model are 5.72 and 13.13%.
Biomonitoring of manganese metal pollution in water and its impacts on biological activities of Biomphalaria alexandrina snail and larvicidal potencies
Authors: Ibrahim Amina Mohamed , Abdel-Haleem Ahmed Abdel-Salam , Taha Rania Gamal 
Published: September 2023

AbstractMetal pollution has many dangerous environmental and human health consequences due to the bioaccumulation in the tissues. The present study aims to measure the bioaccumulation factor of the manganese (Mn) heavy metal in Biomphalaria alexandrina snails’ tissues and water samples. The current results showed the concentration of Mn heavy metal in water (87.5 mg/l) and its bioaccumulation factor in Helisoma duryi tissue was higher than that in tissues of Physa acuta and B. alexandrina snails. Results showed that 87.5 mg/l Mn concentration had miracidicidal and cercaricidal activities. Also, this concentration decreased the mean total number of the hemocytes after exposure for 24 h or 48 h, while increasing both the mean mortality and phagocytic indices of the hemocytes of exposed snails. It caused alterations in the cytomorphology of the hemocytes of exposed snails after 24 or 48 h, where the granulocytes had irregular cell membranes and formed pseudopodia. Besides, levels of testosterone (T) and estradiol (E) were increased after exposure to 87.5 mg/l Mn metal compared to the control group. Also, it increased MDA (malonaldehyde) and TAC (total antioxidant capacity) contents, while decreasing SOD (superoxide dismutase). Besides, it caused significant histopathological damages in both hermaphrodite and digestive glands, represented in the degeneration of the gonadal, digestive, secretory cells, and the connective tissues. Therefore, B. alexandrina might be used as a sensitive bioindicator of pollution with Mn heavy metal to avoid ethics rules; besides, they are readily available and large in number.
Discrimination of human and animal bloodstains using hyperspectral imaging
Authors: Cooney Gary Sean , Köhler Hannes , Chalopin Claire , Babian Carsten 
Published: September 2023

AbstractBlood is the most encountered type of biological evidence in violent crimes and contains pertinent information to a forensic investigation. The false presumption that blood encountered at a crime scene is human may not be realised until after costly and sample-consuming tests are performed. To address the question of blood origin, the novel application of visible-near infrared hyperspectral imaging (HSI) is used for the detection and discrimination of human and animal bloodstains. The HSI system used is a portable, non-contact, non-destructive method for the determination of blood origin. A support vector machine (SVM) binary classifier was trained for the discrimination of bloodstains of human (n = 20) and five animal species: pig (n = 20), mouse (n = 16), rat (n = 5), rabbit (n = 5), and cow (n = 20). On an independent test set, the SVM model achieved accuracy, precision, sensitivity, and specificity values of 96, 97, 95, and 96%, respectively. Segmented images of bloodstains aged over a period of two months were produced, allowing for the clear visualisation of the discrimination of human and animal bloodstains. The inclusion of such a system in a forensic investigation workflow not only removes ambiguity surrounding blood origin, but can potentially be used in tandem with HSI bloodstain age determination methods for rapid on-scene forensic analysis.
Dual RNase activity of IRE1 as a target for anticancer therapies
Authors: Bartoszewska Sylwia , Sławski Jakub , Collawn James F. , Bartoszewski Rafał 
Published: September 2023

AbstractThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate survival and avoid apoptosis even during prolonged cell stress conditions. Here, we discuss different signaling pathways associated with UPR and focus specifically on one of the ER signaling pathways activated during UPR, inositol-requiring enzyme 1α (IRE1). The rationale is that the IRE1 pathway is associated with cell fate decisions and recognized as a promising target for cancer therapeutics. Here we discuss IRE1 inhibitors and how they might prove to be an effective cancer therapeutic.
Graphical abstract
Potential Consciousness of Human Cerebral Organoids: on Similarity-Based Views in Precautionary Discourse
Authors: Diner Sarah 
Published: September 2023

AbstractAdvances in research on human cerebral organoids (HCOs) call for a critical review of current research policies. A challenge for the evaluation of necessary research regulations lies in the severe uncertainty about future trajectories the currently very rudimentary stages of neural cell cultures might take as the technology progresses. To gain insights into organotypic cultures, ethicists, legal scholars, and neuroscientists rely on resemblances to the human brain. They refer to similarities in structural or functional terms that have been established in scientific practice to validate organotypic cultures as models for brain research. In ethical discourse, however, such similarities are also used to justify assumptions about the potential risk to cause harm to HCOs. Ethicists assume that as the technology advances, organotypic cultures will increasingly resemble the human brain, raising more complex ethical issues. I argue that such reasoning is not justified given the heterogeneity of HCOs that have been modified to enable scientists to pursue their research goals. I then discuss the implications this line of thought has for advocates of the precautionary principle, focussing on those suggestions which propose adopting research regulations to the presence of bodily warning signs deemed worthy of protection. In doing so, I illustrate that the prevalent assumptions on similarity in ethical discourse ultimately risk disproportionately restricting research. I conclude that given the severe uncertainty about the technology’s future development, ethical discourse might benefit from narrowing the time frame for anticipation.
The Inventory of Problems–29 is a Cross-Culturally Valid Symptom Validity Test: Initial Validation in a Turkish Community Sample
Authors: Akca Ali Y. E. , Tepedelen Mehmed S. , Uysal Burcu , Erdodi Laszlo A. 
Published: September 2023

AbstractBecause the actuarial evidence base for symptom validity tests (SVTs) is developed in a specific population, it is unclear whether their clinical utility is transferable to a population with different demographic characteristics. To address this, we report here the validation study of a recently developed free-standing SVT, the Inventory of Problems-29 (IOP-29), in a Turkish community sample. We employed a mixed design with a simulation paradigm: The Turkish IOP–29 was presented to the same participants (N = 125; 53.6% female; age range: 19–53) three times in an online format, with instructions to respond honestly (HON), randomly (RND), and attempt to feign a psychiatric disorder (SIM) based on different vignettes. In the SIM condition, participants were presented with one of three scripts instructing them to feign either schizophrenia (SIM-SCZ), depression (SIM-DEP), or posttraumatic stress disorder (SIM-PTSD). As predicted, the Turkish IOP–29 is effective in discriminating between credible and noncredible presentations and equally sensitive to feigning of different psychiatric disorders: The standard cutoff (FDS ≥ .50) is uniformly sensitive (90.2% to 92.9%) and yields a specificity of 88%. Random responding produces FDS scores more similar to those of noncredible presentations, and the random responding score (RRS) has incremental validity in distinguishing random responding from feigned and honest responding. Our findings reveal that the classification accuracy of the IOP–29 is stable across administration languages, feigned clinical constructs, and geographic regions. Validation of the Turkish IOP–29 will be a valuable addition to the limited availability of SVTs in Turkish. We discuss limitations and future directions.
Statistical Appraisal of Major Ion Chemistry of Groundwater: A Case Study from a River-Bounded Rural Area
Authors: Hota Soumya Ranjan , Hota Rabindra Nath , Goswami Shreerup 
Published: September 2023

AbstractThe present study deals with the application of statistical methods like correlation, factor, cluster and multiple regression analyses to interpret the controlling processes influencing the hydrogeochemisty of a river-dominated area. The groundwater is alkaline and hard but suitable for drinking. Most of the parameters show significant positive correlations with each other. The first three factors explain 83.884% of the variance and can be used to assess the dominant hydrochemical processes in operation. The first factor with strong loadings on total dissolved solids (TDS), total hardness (TH), Ca2+, Mg2+, Na+, HCO3- and F- is the salinity factor. It is geogenic in nature and constituent ions are derived from weathering of basement rocks. The second factor with strong loadings on K+, NO3,- SO42-and Cl- is anthropogenic as the first three ions are present in fertilizers used by people to increase crop production and the fourth is derived from domestic wastes. The third factor strongly loaded on pH and total alkalinity (TA) is the alkalinity factor. The cluster analysis replicates the results of the factor analysis. The multiple regression analysis suggests that Ca2+, Mg2+, HCO3- and SO42- contribute significantly to the bulk chemical composition of the groundwater. The chemical constituents of the groundwater may be attributed to the effects of weathering, mineral dissolution, drainage wastes, septic tank leakage, irrigation-return-flows, chemical fertilizers and/or increase or decrease of chemical variables due to dissolution, precipitation, ion exchange, etc. The study illustrates the usefulness of statistical methods as an effective tool for interpretation of the controlling processes of groundwater chemistry.
Algal symbionts of the freshwater sponge Ephydatia muelleri
Authors: Hustus Katelyn , Díez-Vives Cristina , Mitsi Konstantina , Nutakki Jasmine , Kering Victor , Nguyen Ivy T. , Spencer Mayra Gomes , Leys Sally P. , Hill Malcolm S. , Riesgo Ana , Hill April L. 
Published: September 2023

AbstractThe freshwater sponge, Ephydatia muelleri, is an emerging model system for studying animal:microbe symbioses. Intracellular green microalgae are one of the more common symbionts that live in a facultative mutualism with E. muelleri. While these symbioses have long been known, the identity of the algal symbionts in E. muelleri cells has not been studied in detail. Here, we isolate and characterize endosymbiotic algae from E. muelleri collected from different geographic locations. We find that the algae can be transmitted through asexually produced gemmules and importantly that they can form symbioses with different, differentiated sponge cell types in the adult sponge. Our findings indicate that at least two algal lineages form endosymbioses with E. muelleri. One of the lineages includes species commonly found in samples from two locations in Canada and one in the United States (clade 1: closely related to Auxenochlorella pyrenoidosa). The other clade includes algae found in sponges from one site in Maine, USA, and Lewiniosphaera symbiontica, which is a strain isolated in 1956 from the freshwater sponge Spongilla. We compared microbiomes found in cultures of microalgae as well as the original sponge hosts, and found that very similar bacterial microbiomes associate with both clades (91 orders of Bacteria are shared among the samples we compared). The microbiomes found in the cultures resemble, with a high degree of overlap, the microbiome associated with the sponge host.
Self-assembled peptide/polymer hybrid nanoplatform for cancer immunostimulating therapies
Authors: Khazaei Saeedeh , Varela-Calviño Ruben , Rad-Malekshahi Mazda , Quattrini Federico , Jokar Safura , Rezaei Nima , Balalaie Saeed , Haririan Ismaeil , Csaba Noemi , Garcia-Fuentes Marcos 
Published: September 2023

AbstractIntegrating peptide epitopes in self-assembling materials is a successful strategy to obtain nanovaccines with high antigen density and improved efficacy. In this study, self-assembling peptides containing MAGE-A3/PADRE epitopes were designed to generate functional therapeutic nanovaccines. To achieve higher stability, peptide/polymer hybrid nanoparticles were formulated by controlled self-assembly of the engineered peptides. The nanoparticles showed good biocompatibility to both human red blood- and dendritic cells. Incubation of the nanoparticles with immature dendritic cells triggered immune effects that ultimately activated CD8 + cells. The antigen-specific and IgG antibody responses of healthy C57BL/6 mice vaccinated with the nanoparticles were analyzed. The in vivo results indicate a specific response to the nanovaccines, mainly mediated through a cellular pathway. This research indicates that the immunogenicity of peptide epitope vaccines can be effectively enhanced by developing self-assembled peptide-polymer hybrid nanostructures.
Graphical Abstract
The availability of primary rhenium as a by-product of copper and molybdenum mining
Authors: Brainard Jamie L. 
Published: September 2023

AbstractRhenium is a valuable rare metal that is primarily captured as a by-product during the processing of copper and molybdenum. Its complex capture pathway and low annual production (< 100 tons per year) mean that there is limited information about how current capture compares with the amounts of rhenium geologically present in mined material. This study compiles deposit rhenium grades and mine production data to estimate the flow of rhenium in mined material, including through international trade. It is found that less than 12% of rhenium present in ore is captured; however, capture may be as high as 30 to 44% when accounting for technical recovery limits. This has substantial impacts on the future availability of rhenium as the current supply chain faces a geologically imposed limit of rhenium available in ores. Further increases in primary metal capture beyond technical recovery limits can only be achieved by increasing the mining of the copper and molybdenum host ores.