bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Characterization of Bis(pyridylimino)isoindolide Alkali Metal Complexes in Three Redox States
Authors: Wenzel Jonas O. , Fernández Israel , Breher Frank 
Published: June 2023

AbstractNon‐innocent ligands (NILs) like bis(pyridylimino)isoindolide (BPI) play crucial roles in coordination chemistry, biosciences, catalysis and material sciences. Investigating the isolated redox states of NILs is inevitable for understanding their redox‐activity and fine‐tuning the properties of corresponding metal complexes. The limited number of fundamental studies on the coordination behavior and redox chemistry of reduced BPI species is suggested to hamper further applications of the title compounds. This work describes for the first time the isolation of alkali metal complexes of BPI and Me2BPI in three different oxidation states and their characterization by means of NMR or EPR spectroscopy, DFT calculations, and SC‐XRD studies. The latter revealed the connection between bond orders in the ligand scaffold and its oxidation state. The paramagnetic compound Me2BPI‐K2 was isolated as a coordination copolymer with 18‐crown‐6, which enabled the characterization of the dianionic BPI radical. Furthermore, the so‐far unknown trianionic state of BPI was reported by the isolation of BPI‐K3. This divulges an unprecedented bis(amidinato)isoindolide coordination mode.
Stereocomplementary Synthesis of β‐Aryl Propanamines by Enzymatic Dynamic Kinetic Resolution‐Reductive Amination
Authors: Jin Rui , Xu Zefei , Feng Jinhui , Wang Min , Yao Peiyuan , Wu Qiaqing , Zhu Dunming 
Published: June 2023

AbstractChiral β‐aryl propanamine is an important structure unit of bioactive molecules or drugs. But its efficient synthesis remains a challenging task. In this study, several enantiocomplementary imine reductases capable of dynamic kinetic resolution‐reductive amination of sixteen 2‐phenylpropanal derivatives of diverse structural characteristics with four different amines were identified through screening 196 imine reductases. Furthermore, (S)‐IR60, (R)‐IR74 and (R)‐IR207 were applied to access a series of different β‐aryl propanamines with excellenteevalues (90 to 99 %) and high isolated yields (36 to 79 %), and two of them were further transformed into 3‐methylindolines through intramolecular Buchwald‐Hartwig cross‐coupling and deallylation, providing an effective method to construct this class of pharmaceutically important compounds.
Palladium‐Catalyzed Hydroaminocarbonylation of Olefins with Aliphatic Amines without Additives
Authors: Bede Fanni , Kollár László , Lambert Nándor , Huszthy Péter , Pongrácz Péter 
Published: June 2023

AbstractPalladium‐catalyzed hydroaminocarbonylation reactions of olefins using aliphatic amines were performed under carbon monoxide atmosphere. Despite the strong basicity of the applied nucleophiles, the targeted amides were successfully synthesized in the absence of acidic additives. Styrene, oct‐1‐ene and isoprene were transformed to the corresponding amide isomers in moderate to good isolated yields under optimized reaction conditions. Various aliphatic amines were used as N‐nucleophiles. The effect of chiral diphosphines on product distribution, that is, on chemo‐, regio‐ and enantioselectivities was also studied. Plausible explanation was given for the additive‐free hydroaminocarbonylation reaction.
Reductions in Bone Mineral Density Are Apparent Early in Children With Prevalent Osteonecrosis Lesions Following Leukemia Therapy
Authors: Halton Jacqueline M. , Ma Jinui , Babyn Paul , Matzinger Mary Ann , Kaste Sue C. , Scharke Maya , Fernandez Conrad V. , Miettunen Paivi , Ho Josephine , Alos Nathalie , Abish Sharon , Barr Ronald , Cairney Elizabeth , Dix David B. , Grant Ronald M. , Israels Sara , Lewis Victor , Wilson Beverly , Atkinson Stephanie , Cabral David , Cummings Elizabeth , Rodd Celia , Stein Robert , Sbrocchi Anne Marie , Jaremko Jacob L. , Koujok Khaldoun , Shenouda Nazih , Rauch Frank , Siminoski Kerry , Ward Leanne M. ,   the Canadian STOPP Consortium
Published: June 2023

AbstractOsteonecrosis (ON) is a serious complication of childhood acute lymphoblastic leukemia. We determined the prevalence of osteonecrotic lesions in our patient population by a one‐time multisite magnetic resonance imaging (MRI) more than 1 year following leukemia therapy. MRI findings were evaluated in relationship to clinical factors (including longitudinal changes in bone mineral density [BMD]). Eighty‐six children enrolled in the Steroid Associated Osteoporosis in the Pediatric Population (STOPP) study were evaluated for ON at 3.1 ± 1.3 years following therapy. Thirty children had a total of 150 confirmed ON lesions (35%). Lumbar spine (LS) BMD Z‐scores (mean ± SD) were low at diagnosis and similar between patients with and without ON (−1.09 ± 1.53 versus −1.27 ± 1.25, p = 0.549). LS BMD Z‐scores declined from baseline to 12 months in children with ON (−0.31 ± 1.02) but not in those without (0.13 ± 0.82, p = 0.035); the hip BMD Z‐scores from baseline to 24 months declined in both groups, but to a greater extent in those with ON (−1.77 ± 1.22) compared to those without (−1.03 ± 1.07, p = 0.045). At the time of the MRI, mean total hip and total body (TB) BMD Z‐scores were lower in children with ON (hip −0.98 ± 0.95 versus −0.28 ± 1.06, p = 0.010; TB −1.36 ± 1.10 versus −0.48 ± 1.50, p = 0.018). Pain occurred in 11/30 (37%) with ON versus 20/56 (36%) without, p = 0.841. In multivariable models, older age at diagnosis (odds ratio [OR] 1.57; 95% confidence interval [CI], 1.15–2.13; p = 0.004), and hip BMD Z‐score at MRI (OR 2.23; 95% CI, 1.02–4.87; p = 0.046) were independently associated with ON. Overall, one‐third of children demonstrated ON after leukemia therapy. Those with ON had greater reductions in spine and hip BMD Z‐scores in the first 1 and 2 years of therapy, respectively. Older age and lower hip BMD Z‐scores at MRI were significantly associated with prevalent, off‐therapy ON. These data assist in identifying children at risk of ON. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Clinical effectiveness of oral antiviral agents in older patients with COVID‐19 based on real‐world data
Authors: Tsai Ya‐Wen , Wu Jheng‐Yan , Liu Ting‐Hui , Chuang Min‐Hsiang , Hsu Wan‐Hsuan , Huang Po‐Yu , Lai Chih‐Cheng , Tsai Kang‐Ting , Shiue Yow‐Ling 
Published: June 2023

AbstractSeveral randomized controlled trials and real‐world cohort studies have demonstrated the efficacies of nirmatrelvir plus ritonavir (NMV‐r) and molnupiravir (MOV) in at‐risk patients with COVID‐19; however, the effectiveness of antisevere acute respiratory syndrome‐coronavirus 2 treatments on older patients (≥65 years) remains unclear. This retrospective cohort study aimed to assess the clinical effectiveness of the oral antiviral agents, MOV and NMV‐r, in older patients (≥65 years) infected with severe acute respiratory syndrome‐coronavirus 2. Nonhospitalized older patients with COVID‐19 between January 1, 2022, and December 31, 2022, were recruited from the TriNetX Research Network. Propensity score matching (PSM) was used to match patients who received either NMV‐r or MOV treatment with those who did not receive any oral antiviral agents. Hazard ratios (HRs) for composite all‐cause hospitalization or death during the 30‐day follow‐up period were calculated. PSM revealed two cohorts with 28 824 patients each having balanced baseline characteristics. The antiviral group was associated with significantly lower risk of the primary composite outcome of all‐cause hospitalization or death than the control group (241 vs. 801; HR, 0.307; 95% confidence interval (CI), 0.27–0.36) during the follow‐up period. For the secondary outcome, the antiviral group had a significantly lower risk of all‐cause hospitalization (288 vs. 725; HR, 0.322; 95% CI, 0.28–0.37) and mortality (16 vs. 94; HR, 0.176; 95% CI, 0.10–0.30) than the control group. Moreover, the reduced risk of all‐cause hospitalization or death remained consistent in patients receiving NMV‐r (HR, 0.279; 95% CI, 0.24–0.33) and MOV (HR, 0.279; 95% CI, 0.21–0.38). Our results revealed that NMV‐r and MOV decreased the all‐cause hospitalization and death rates among older patients with COVID‐19, supporting the use of antivirals in this vulnerable population.
Oral health‐related quality of life among women early postpartum: A cross‐sectional study
Authors: Badewy Rana , Cardoso Elaine , Glogauer Michael , Sgro Michael , Connor Kristin L. , Lai Jim Yuan , Bazinet Richard P. , Tenenbaum Howard C. , Azarpazhooh Amir 
Published: June 2023

AbstractBackgroundPeriodontal diseases can negatively impact the oral health‐related quality of life (OHRQoL) of pregnant women. This study investigates the association between maternal oral inflammatory load (OIL), sociodemographic characteristics, and the OHRQoL in postpartum women.MethodsIn this cross‐sectional study, breastfeeding mothers were recruited from St. Michael's Hospital, Toronto within 2–4 weeks postpartum. Mothers were categorized into “Normal/low” and “High” OIL groups based on the absolute counts of oral polymorphonuclear neutrophils (oPMNs). The Oral Health Impact Profile‐14 questionnaire was used to assess the impact of the maternal OIL on the OHRQoL. Multiple linear regression analyses were performed to examine the association between maternal sociodemographic factors including age, marital status, education level, employment status, parity, and their OHRQoL.ResultsForty‐seven mothers were included in this study. Mothers with high OIL reported higher impact on their OHRQoL (30%) than mothers with normal/low OIL (21%), but these differences were not statistically different. There was a negative relationship between the mother's education level and the extent of impact of OHRQoL on the “physical pain” dimension (p < 0.05), and between the mothers’ age and employment status and the “physical disability” dimension (p < 0.05). A positive correlation was noted between multi‐parity and the extent of impact of OHRQoL on the “physical disability” dimension (p = 0.009), and between the marital status and the “psychological disability” dimension (p < 0.05).ConclusionThis study highlighted the significant impact of sociodemographic characteristics on the OHRQoL of mothers, showcasing the importance of considering these factors when implementing targeted preventive dental care programs for mothers.
Use of Motion Capture Technology to Study Extrinsic Laryngeal Muscle Tension and Hyperfunction
Authors: Hogue Steven , Guo Xiaohu , Morrison Robert A. , McDowell Sarah , Shembel Adrianna C. 
Published: June 2023

ObjectivesPatients with primary muscle tension dysphonia (pMTD) commonly report paralaryngeal pain and discomfort, and extrinsic laryngeal muscle (ELM) tension and hyperfunction are commonly implicated. However, quantitative physiological metrics to study ELM movement patterns for the characterization of pMTD diagnosis and monitoring of treatment progress are lacking. The objectives of this study were to validate motion capture (MoCap) technology to study ELM kinematics, determine whether MoCap could distinguish ELM tension and hyperfunction between individuals with and without pMTD, and investigate relationships between common clinical voice metrics and ELM kinematics.MethodsThirty subjects (15 with pMTD and 15 controls) were recruited for the study. Sixteen markers were placed on different anatomical landmarks on the chin and anterior neck. Movements across these regions were tracked during four voice and speech tasks using two three‐dimensional cameras. Movement displacement and variability were determined based on 16 key‐points and 53 edges.ResultsIntraclass correlation coefficients demonstrated high intra‐ and inter‐rater reliability (p's < 0.001). Other than greater movement displacements around the thyrohyoid space during longer phrasing (reading passage, 30‐s diadochokinetics) and more movement variability in patients with pMTD, kinematic patterns between groups were similar across the 53 edges for the four voice and speech tasks. There were also no significant correlations between ELM kinematics and standard voice metrics.ConclusionResults demonstrate the feasibility and reliability of MoCap for the study of ELM kinematics.Level of Evidence3 Laryngoscope, 133:3472–3481, 2023
Microinjection Molded Biopolymeric Airway Stent with Antibacterial and Anti‐Hyperplastic Properties
Authors: Dong Jiahui , Li Yahua , Wang Xiaofeng , Liu Yajing , Ren Kewei , Liu Xuedi , Zhang Han , Li Zongming , Han Xinwei , Uyama Hiroshi , Li Qian 
Published: June 2023

AbstractCentral airway stenosis is a condition that the diameter of the trachea or main bronchus shrinkage is caused by external compression or internal tissue hyperplasia, which can cause difficulty breathing, asphyxia, and even death. Airway stenting is an easy way to restore the patency of the central airway, but airway stents commonly used in clinical practice can lead to complications such as mucus plugging, bacterial infection, and granulation tissue hyperplasia. Moreover, the non‐degradable characteristic makes it requires a second operation to remove, which has the potential to cause tissue damage. In this study, a biodegradable airway stent is fabricated by microinjection molding using the bioelastomer of poly (L‐lactide‐co‐ε‐caprolactone) as the matrix material. The airway stent has excellent mechanical properties and an appropriate degradation rate. The hydrophilic surface of the airway stent can inhibit mucus plugging. The loading of silver nanoparticles and cisplatin endows the stent with antibacterial and anti‐hyperplastic functions. In vitro and in vivo experiments demonstrate that this study provides an antibacterial and anti‐hyperplastic biodegradable airway stent with elastic properties to avoid secondary removal operation and reduce complications associated with mucus plugging, bacterial infection, and granulation tissue hyperplasia.
Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide
Authors: Sarkar Santu , Kumar Rajnish , Matson John B. 
Published: June 2023

AbstractGasotransmitters, gaseous signaling molecules including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), maintain myriad physiological processes. Low levels of gasotransmitters are often associated with specific problems or diseases, so NO, CO, and H2S hold potential in treating bacterial infections, chronic wounds, myocardial infarction, ischemia, and various other diseases. However, their clinical applications as therapeutic agents are limited due to their gaseous nature, short half‐life, and broad physiological roles. One route toward the greater application of gasotransmitters in medicine is through localized delivery. Hydrogels are attractive biomedical materials for the controlled release of embedded therapeutics as they are typically biocompatible, possess high water content, have tunable mechanical properties, and are injectable in certain cases. Hydrogel‐based gasotransmitter delivery systems began with NO, and hydrogels for CO and H2S have appeared more recently. In this review, the biological importance of gasotransmitters is highlighted, and the fabrication of hydrogel materials is discussed, distinguishing between methods used to physically encapsulate small molecule gasotransmitter donor compounds or chemically tether them to a hydrogel scaffold. The release behavior and potential therapeutic applications of gasotransmitter‐releasing hydrogels are also detailed. Finally, the authors envision the future of this field and describe challenges moving forward.
Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET The Neurodiagnostic Society
Authors: López Jaime R. , Ahn‐Ewing Judy , Emerson Ron , Ford Carrie , Gale Clare , Gertsch Jeffery H. , Hewitt Lillian , Husain Aatif , Kelly Linda , Kincaid John , Kise Meledy , Kornegay Adam , Moreira Joseph J. , Nuwer Marc , Schneider Anita , Stecker Mark , Sullivan Lucy R. , Toleikis J. Richard , Wall Lois , Herman Susan 
Published: June 2023

AbstractThe Guidelines for Qualifications of Neurodiagnostic Personnel (QNP) document has been created through the collaboration of the American Clinical Neurophysiology Society (ACNS), the American Society of Neurophysiological Monitoring (ASNM), the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM), and ASET The Neurodiagnostic Society (ASET). The quality of patient care is optimized when neurophysiological procedures are performed and interpreted by appropriately trained and qualified practitioners at every level. These societies recognize that neurodiagnostics is a large field with practitioners who have entered the field through a variety of training paths. This document suggests job titles, associated job responsibilities, and the recommended levels of education, certification, experience, and ongoing education appropriate for each job. This is important because of the growth and development of standardized training programs, board certifications, and continuing education in recent years. This document matches training, education, and credentials to the various tasks required for performing and interpreting neurodiagnostic procedures. This document does not intend to restrict the practice of those already working in neurodiagnostics. It represents recommendations of these societies with the understanding that federal, state, and local regulations, as well as individual hospital bylaws, supersede these recommendations. Because neurodiagnostics is a growing and dynamic field, the authors fully intend this document to change over time.
3βHSD activity saturates at physiological substrate concentrations in intact cells
Authors: McManus Jeffrey M. , Chung Yoon‐Mi , Sharifi Nima 
Published: June 2023

AbstractBackgroundConversion of adrenally produced dehydroepiandrosterone (DHEA) to the potent androgen dihydrotestosterone (DHT) is an important mechanism by which prostate cancer reaches castration resistance. At the start of this pathway is a branch point at which DHEA can be converted to Δ4‐androstenedione by the enzyme 3β‐hydroxysteroid dehydrogenase (3βHSD) or to Δ5‐androstenediol by 17βHSD. To better understand this process, we studied the kinetics of these reactions in cells.MethodsProstate cancer cells (LNCaP cell line) were incubated with steroids (DHEA and Δ5‐androstenediol) over a range of concentrations and the steroid metabolism reaction products were measured by mass spectrometry or by high‐performance liquid chromatography to determine reaction kinetics. To confirm the generalizability of results, experiments were also performed in JEG‐3 placental choriocarcinoma cells.ResultsThe two reactions displayed very different saturation profiles, with only the 3βHSD‐catalyzed reaction beginning to saturate within a physiological substrate concentration range. Strikingly, incubating LNCaP cells with low (in the ~10 nM range) concentrations of DHEA resulted in a large majority of the DHEA undergoing 3βHSD‐catalyzed conversion to Δ4‐androstenedione, whereas high concentrations of DHEA (in the 100s of nM range) resulted in most of the DHEA undergoing 17βHSD‐catalyzed conversion to Δ5‐androstenediol.ConclusionContrary to expectations from previous studies that used purified enzyme, cellular metabolism of DHEA by 3βHSD begins to saturate in the physiological concentration range, suggesting that fluctuations in DHEA concentrations could be buffered at the downstream active androgen level.
Ecodesign approach for plastic minimization in shampoo bottles
Authors: Vazquez Yamila V. , Dutari Teresa , Castillo Luciana A. , Barbosa Silvia E. 
Published: June 2023

AbstractCurrent shampoo bottles are oversized, using more plastic than necessary. In order to promote plastic minimization, the aim of this work is to determine how much it is possible to reduce the thickness of current shampoo bottles while maintaining their functionality and performance. In this way, a quantification of the maximum plastic material reduction in the manufacturing of bottles of massively consumed shampoo was assessed. Mechanical testing simulations of shampoo bottles with different capacities and shapes were performed for top load and squeeze load efforts. For these simulations, three different thicknesses were considered: original, 30% reduced and the minimum admissible for being considered as rigid packaging. From the simulations, it was corroborated that shampoo bottles are oversized, allowing them to reduce their amount of plastic by at least 30%. Also, it was found that bottle shape is crucial to its mechanical performance, being the simplest bottle the most resistant, when bottles with the same capacity and thickness are compared. When less material is used, less is discarded, and, consequently, less is turned into waste. Then, rethinking current bottles following ecodesign criteria seems to be the way for an adequate sustainable approach compatible with green marketing strategies and plastic waste minimization.
Flexible Luminescent Hydrogen‐bonded Organic Framework for the Separation of Benzene and Cyclohexane
Authors: Liang Meng , Hu Siwen , Zhou Ningning , Liu Zhongyi , Chen Qiao , Chen Xinyu , Liu Xingliang , Li Cheng‐Peng , Hao Jingjun , Xue Pengchong 
Published: June 2023

AbstractA nonplanar phenothiazine derivative with three cyano moieties (PTTCN) is designed and synthesized to achieve functional crystals for absorptive separation of benzene and cyclohexane. PTTCN can crystallize into two kinds of crystals with different fluorescence colors in different solvent systems. The molecules in two crystals are in different stereo isomeric forms of nitrogen, quasi axial (ax), and quasi equatorial (eq). The crystals with blue fluorescence in ax form may selectively adsorb benzene by a single‐crystal‐to‐single‐crystal (SCSC) transformation, but separated benzene from a benzene/cyclohexane equimolar mixture with a low purity of 79.6%. Interestingly, PTTCN molecules with eq form and benzene co‐assembled to construct a hydrogen‐bonded framework (X‐HOF‐4) with S‐type solvent channels and yellow‐green fluorescence, and can release benzene to form nonporous guest‐free crystal under heating. Such nonporous crystals strongly favor aromatic benzene over cyclohexane and may selectively reabsorb benzene from benzene/cyclohexane equimolar mixture to recover original framework, and the purity of benzene can reach ≈96.5% after release from framework. Moreover, reversible transformation between the nonporous crystals and the guest‐containing crystals allows the material to be reused.