bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Plant Bioactive as Diuretics: General Considerations and Mechanism
of Diuresis
Authors: Manvi  , Khan Mohammad Irfan , Badruddeen  , Akhtar Juber , Ahmad Mohammad , Siddiqui Zeba , Fatima Gayyur 
Published: June 2023

Background:
Medicinal plants have been found beneficial in the control and therapy of many ailments as they contain bioactive compounds, and many of them are used as precursors in the biosynthesis of natural medicines. Diuretics are used as a primary treatment in patients with edema associated with liver cirrhosis and kidney diseases, hyperkalemia, hypertension, heart fail-ure, or renal failure. Furthermore, they are also used to increase the excretion of sodium and re-duce blood volume. Due to various adverse events associated with synthetic diuretics, there is a need to investigate alternate plant-based bioactive components that have effective diuretic activity with minimal side effects.

Objective:
This review compiled the reported bioactive compounds from different plant sources along with their mechanisms of diuretic activity.

Methods:
Different sources were used to collect information regarding herbal plants with thera-peutic value as diuretics. These included published peer-reviewed journal articles, scholarly arti-cles from StatPearls, and search engines like Google Scholar, PubMed, Scopus, Springer, Sci-enceDirect, Wiley, etc.

Results:
In this review, it was found that flavonoids like rutin, acacetin, naringenin, etc. showed significant diuretic activity in experimental models by various mechanisms, but mostly by block-ing the sodium-potassium-chloride co-transporter, while some bioactive compounds showed diu-retic actions via other mechanisms as well.

Conclusion:
Research on clinical trials of these isolated bioactive compounds needs to be further conducted. Thus, this review provides an understanding of the potential diuretic bioactive com-pounds of plants for further research and pharmaceutical applications.
Endless Journey of Adenosine Signaling in Cardioprotective Mechanism of
Conditioning Techniques: Clinical Evidence
Authors: Kumar Kuldeep , Singh Nirmal , Yadav Harlokesh Narayan , Maslov Leonid , Jaggi Amteshwar Singh 
Published: June 2023

Abstract:
Myocardial ischemic injury is a primary cause of death among various cardiovascular
disorders. The condition occurs due to an interrupted supply of blood and vital nutrients (necessary
for normal cellular activities and viability) to the myocardium, eventually leading to damage. Restoration
of blood supply to ischemic tissue is noted to cause even more lethal reperfusion injury.
Various strategies, including some conditioning techniques, like preconditioning and postconditioning,
have been developed to check the detrimental effects of reperfusion injury. Many endogenous
substances have been proposed to act as initiators, mediators, and end effectors of these conditioning
techniques. Substances, like adenosine, bradykinin, acetylcholine, angiotensin, norepinephrine,
opioids, etc., have been reported to mediate cardioprotective activity. Among these
agents, adenosine has been widely studied and suggested to have the most pronounced cardioprotective
effects. The current review article highlights the role of adenosine signaling in the cardioprotective
mechanism of conditioning techniques. The article also provides an insight into various
clinical studies that substantiate the applicability of adenosine as a cardioprotective agent in myocardial
reperfusion injury.
3D Synthetic Brain MRI with Compressed Sensing: A Promising Way Forward for Daily Neuroimaging
Authors: Baek Hye Jin , Heo Young Jin , Cho Eun , Lee Kwangho 
Published: June 2023

Background:
Synthetic MRI can provide multiple contrast-weighted brain images with high resolution from a single scan via a 3D sequence using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse (3D-QALAS).

Objective:
This study aimed to assess the diagnostic image quality of 3D synthetic MRI using compressed sensing (CS) in clinical practice.

Methods:
We retrospectively reviewed the imaging data of 47 patients who underwent brain MRI, including 3D synthetic MRI using CS in a single session, between December 2020 and February 2021. Two neuroradiologists independently evaluated the overall image quality, anatomic demarcation, and artifacts for synthetic 3D T1-weighted, T2-weighted, FLAIR, phase-sensitive inversion recovery (PSIR), and double inversion recovery images, using a 5-point Likert scale. The interobserver agreement between the two readers was assessed using percent agreement and weighted κ statistics.

Results:
The overall image quality of 3D synthetic T1WI and PSIR was good to excellent, with easy or excellent anatomic demarcation and mild or no visible artifact. However, other 3D synthetic MRI-derived images showed insufficient image quality and anatomic demarcation with marked CSF pulsation artifacts. In particular, 3D synthetic FLAIR showed high-signal artifacts on the brain surface.

Conclusion:
3D synthetic MRI, at its current status, cannot completely replace conventional brain MRI in daily clinical practice. However, 3D synthetic MRI can achieve scan-time reduction using CS and parallel imaging and may be useful for motion-prone or pediatric patients requiring 3D images where time-efficiency is important.
Suten Games: Exploration of Empirical and Theoretical Probability for Junior High School Mathematics Learning
Authors: Oktaviani Dewi , Kinasih Dewi 
Published: June 2023

Suten is one of the local games often played for determining a purpose fairly. The game is played in pairs by choosing Elephant, Ant, or Man by each player. The choosing is one of the applications of the probability concept learned by students of the junior-high school. The use of the game in the instructional process can aid students in relating the probability concept they learn to real events. The objective of the present study is to explore the concepts of empirical and theoretical probabilities in the Suten game. The study is descriptive qualitative with an ethnographic approach to present detailed description and analysis concerning the Suten game in relation to probability material. Research results show the finding of the concepts of empirical and theoretical probabilities in the Suten game, especially in showing whether or not that Suten is a fair game. The game can be used in mathematics learning to introduce to students the concepts empirical probability, sample space, sample point, and theoretical probability. In addition, positive aspects can be obtained when the Suten game is integrated in learning such as, among others, inter-appraisal of decisions, training intuition, and using the abilities of creative thinking in searchimg for strategies.
Analisis Indeks Keandalan Secara Teknis Dan Ekonomis Jaringan Distribusi 20 kV Menggunakan Metode Section Tekhnique Pada PT.PLN (Persero) Rayon Belawan
Authors: Sihombing Gunawan 
Published: June 2023

ABSTRACTThe purpose of this study is to analyze the reliability index of SAIDI, SAIFI and CAIDI using the Section Technique method and evaluate the reliability according to the IEEE Std 1366-2003 Reliability Index Standard. PLN (Persero) Belawan District. Based on the results of the reliability index analysis using the section technique method, the SAIFI reliability index value for the Lamhotma 01 feeder (LH01) is 1.6 times customers/year, exceeding the standard set by IEEE Std 1366-2003 which is 1.45 times customers/year, and meets the standard. SPLN is set at 3.0 times customers/year. The SAIDI value of the Lamhotma 01 feeder (LH01) is 2.0 hours/year. 6 hours/customer exceeds the standard set by IEEE-1366-2003 which is 1.47 hours/customer and exceeds the standard set by SPLN. And the energy that is not distributed (ENS) due to the blackout at the Lamhotma feeder in 2021 is 32681.33 kWh and the average energy is not channeled 4.7 kWh / customer and the economic loss is estimated at Rp 40,105.090.00.ABSTRAKTujuan penelitian ini adalah menganalisis indeks keandalan SAIDI, SAIFI dan CAIDI menggunakan metode Section Technique dan mengevaluasi keandalan sesuai dengan Standar Indeks Keandalan IEEE Std 1366 – 2003. Mengetahui rata-rata energi yang tidak tersalurkan secara teknis dan ekonomis akibat terjadinya pemadaman di PT. PLN (Persero) Rayon Belawan. Berdasarkan hasil analisis indeks keandalan dengan menggunakan metode section tekhnique nilai indeks keandalan SAIFI penyulang Lamhotma 01 (LH01) adalah 1,6 kali pelanggan/tahun melebihi standar yang ditetapkan oleh IEEE Std 1366-2003 yaitu 1,45 kali pelanggan/tahun, dan memenuhi standar yang di tetapkan SPLN sebesar 3,0 kali pelanggan/tahun. Nilai SAIDI penyulang Lamhotma 01 (LH01) adalah Sebesar 2,0 jam/tahun memenuhi standar yang telah di tetapkan IEEE std 1366-2003 yaitu 2.30 jam/tahun, dan juga memenuhi standar SPLN, dan nilai CAIDI penyulang Lamhotma (LH01) adalah 4,6 jam/pelanggan melebihi standar yang di tetapkan IEEE-1366-2003 yaitu 1,47 Jam/pelanggan, dan juga melebihi standar yang di tetapkan SPLN. Serta energi yang tidak tersalurkan (ENS) akibat terjadinya pemadaman pada penyulang Lamhotma tahun 2021 sebesar 32681,33 kWh dan rata-rata energi tak tersalurkan 4,7 kwh/pelanggan dan kerugian ekonomis diperkirakan sebesar Rp 40.105.090,00.
Respiratory status and behavioral response of premature infant with nesting model care approach in neonatal intensive care unit
Authors: Tuti Seniwati  , Nurmaulid Nurmaulid , Abdul Kadir  , Irmayanti Irmayanti 
Published: June 2023

Introduction: The increase in mortality of newborns, especially premature babies, is caused by non-optimal lung development where the production of less surfactant triggers lung collapse and compliance. This causes stress on the newborn and requires more intensive care. One of the care taken to overcome these problems is the nesting application. Objectives: To identify the effect of nesting model care on premature infants' respiratory status and behavioral responses. Methods: This study is a quasi-experimental design with a pre-post-test group design. The samples were premature infants admitted to the Neonatal Intensive Care Unit (NICU), with as many as 40 respondents. The sampling technique is purposive sampling. Data were analyzed using the Mann-Whitney test and Wilcoxon test. Results: The results showed no significant differences between the respiratory status in modern and conventional nesting, with P-value = 0.292. While there was a significant difference in behavioral responses, both groups with P = 0.027. There was an effect on respiratory status before and after nesting in the modern nesting group where the significance P = 0.001 and no effect in the conventional nesting group with a P value = 0066. Regarding behavioral responses, there was a significant value in two of the group before and after nesting, where the value significance respectively P = 0.009 and P = 0.025. Conclusions: Modern nesting influences scores and behavioral responses in premature infants, while conventional nesting only affects reducing the score of behavioral responses. It is expected that the use of nesting in the NICU room specifically for premature babies prefers the use of modern nesting compared to conventional nesting babies to maintain stability in terms of both respiratory and response behavior.
The correlation between self awareness and prediabetes status in patients with excess weight in polyclinic of Baladhika Husada Hospital Jember
Authors: Sukma Anindianti , Sutawardana Jon Hafan , Kushariyadi Kushariyadi 
Published: June 2023

Introduction: Poor lifestyle and eating patterns can cause energy imbalances, which can cause excess weight. Excess weight increase risk of pre-diabetes than healthy body weight. Many people who do not know they have pre-diabetes, they have lack of self-awareness to prevent diabetes mellitus. Objectives: This research aims to determine the relationship between self-awareness and pre-diabetes status in patients with excess weight in Polyclinic of Baladhika Husada Hospital in Jember. Methods: This research uses an analytic design with a cross-sectional approach. There were 84 respondents obtained from the accidental sampling technique. Data were collected from the Self Awareness Diabetes Mellitus and random blood glucose results. Data were analyzed using Spearman-rank. Result: Based on the statistical test results, there was a significant relationship between self-awareness and prediabetes status with the direction of negative correlation, which means the higher the self-awareness, the lower the respondents have prediabetes. In patients who were overweight, there was a buildup of fat in the body that can reduce insulin work, which affects prediabetes. While self-awareness as an attitude that must be possessed by someone with excess weight to prevent the risk of prediabetes. Discussion: This study showed the importance of increasing self-awareness and implementing blood glucose control routinely so that someone who has entered the prediabetes category can improve their lifestyle to prevent diabetes mellitus.
Education model on SMS gateway on blood sugar levels of diabetes mellitus patients
Authors: Febriyanti Febriyanti , Yusril Viki , Guci Asriwan 
Published: June 2023

Introduction: Diabetes has become a global epidemic over the last two decades, the prevalence has doubled, from 4.6% to 9.3% in the population aged 20-79 years. Based on data from the International Diabetes Federation (IDF) 2019, it is estimated that 463 million people in the above age group live with diabetes of which 90% Diabetes, Indonesia faces the same diabetes threat as the world, within five years. West Sumatra is at number 21 out of 34 provinces with diabetes cases. Based on data from the Padang City Health Office in 2020, from 23 health centers in Padang City, Andalas Health Center is the highest coverage of type 2 diabetes mellitus, which is 1017 people. Of the 10 sub-districts in the Andalas Community Health Center working area, Jati sub-district is the highest case of diabetes mellitus. Good blood sugar control is one of the important factors and has been shown to reduce the risk of complications in people with diabetes, to achieve good blood glucose control, holistic management is needed including education, education with an SMS gateway approach can provide continuous and continuous information. Objectives: see the effect of SMS gateway-based education model on blood sugar levels of diabetics. Methods: Pre-experiment using the One Group Pretest-Posttest design approach. Data analysis using Paired T-test sample. Results: The results showed that there was an effect of education model based on sms gateway based education model on blood sugar levels of diabetics with p-value = 0.002. Conclusions: SMS gateway-based education model affects blood sugar levels of diabetics.
Difference of allergic reaction on hand sanitizer gel and liquid among nurses at RSU Karsa Husada Batu
Authors: Adilah Lilah 
Published: June 2023

Introduction: The program to improve the hand hygiene of health workers has been declared by WHO through a patient safety program that sparked the Global Patient Safety Challenge "clean care is safe care". Hand hygiene practice, health workers may use the gel or liquid form of hand sanitizer with alcohol-based ingredients. However, alcohol is flammable, causing dryness and irritation of the skin on repeated use and increases the risk of viral infections that trigger inflammation of the digestive tract. Objectives: Researcher would like to find any difference on allergic reaction between the use of hand sanitizer gel and liquid form which were commonly used by nurses at RSU Karsa Husada Batu during hand hygiene practice. Methods: The research design used is a survey research with a cross sectional approach where the researcher observes the research subjects using a check list and questionnaire, with a sample of 80 respondents. The data analysis used non-parametric statistics Mc-Nemar test. Results: The results of the Mc-Nemar Test showed a p value of 0.033 < 0.05 which means that the use of hand sanitizer gel and liquid has a significant difference in the allergic reaction among nurses. Conclusions: Hand sanitizer in gel or liquid form were safe as long as use correctly and properly, also selecting a type of hand sanitizer must be matched with the individual skin
Prevalence of Isotretinoin Therapy in Adolescents and Young Adults With and Without Atopic Dermatitis: A Nationwide Prescription-based Population Study
Authors: Mohn Cathrine H. , Blix Hege S. , Brænd Anja Maria , Nafstad Per , Halvorsen Jon Anders 
Published: June 2023

Although isotretinoin has anti-inflammatory and immunomodulatory properties, it can exacerbate atopic dermatitis. National estimates of the extent to which patients with atopic dermatitis are affected by severe acne and isotretinoin tolerability are lacking. The aim of this study is to investigate isotretinoin therapy in patients with atopic dermatitis and to compare the nationwide prevalence with individuals without atopic dermatitis. All Norwegian residents were followed for 17 years until age 20–22 years in 2020. Approximately 28% of patients with atopic dermatitis had been treated for acne, and 8% had received isotretinoin before age 23 years. In those over 17 years old, significantly more patients with atopic dermatitis were treated with isotretinoin than those without. At age 22 years, 2.21% (95% confidence interval 1.92–2.49) of patients with atopic dermatitis were treated with isotretinoin, compared with 1.55% (95% confidence interval 1.44–1.65) of those without, representing 42.8% (1.43; 95% confidence interval 1.24–1.65) higher use in patients with atopic dermatitis. Patients who received long-term treatment (probable severe atopic dermatitis) tolerated isotretinoin similarly to patients who received short-term treatment (probable mild atopic dermatitis). There was significantly higher use of topical corticosteroids during isotretinoin therapy in patients with atopic dermatitis. Conclusively, severe acne (isotretinoin therapy) was associated with atopic dermatitis at the population level in young adults.
Cruzeiro Seixas: Weird Corpses and Why the Portuguese Surrealism Did Not Die
Authors: Castro Paulo Alexandre 
Published: June 2023

Cruzeiro Seixas is one of the main representatives of Portuguese and European surrealism, despite having initially started with neo-realism. Alongside figures such as Mário Cesariny, Carlos Calvet, António Maria Lisboa, Pedro Oom or Mário Henrique Leiria, the artist created a very unique style that allows immediate recognition of his work. If it is true that this recognition depends a lot on the pictorial, stylistic, artistic presentation, it is no less true that this happens due to the permanent use of a language that, on the one hand, keeps surrealism alive, and on the other hand, allows the affirmation of a narrative that does not run out of time in the discourses of history or art criticism. It is not a question of reinventing surrealism but of making it known as it is, as it happens in the reality of the human psyche. And what happens is images of weird corpses in unreal scenarios, as it must be all the mind scenarios. Cruzeiro Seixas is an artist of human reality and this essay seeks to give an account of his work and thereby clarify how surrealism remains alive today.
INOVASI PROGRAM KLAMPID NEW GENERATION SEBAGAI PERWUJUDAN PELAYANAN PRIMA KEPADA MASYARAKAT (STUDI KASUS PADA PROGRAM KARTU IDENTITAS ANAK DI KELURAHAN BARATAJAYA KOTA SURABAYA)
Authors: Sea Yusta Arisendy , Novaria Rachmawati , Wahyudi Eddy 
Published: June 2023

Inovasi pelayanan publik menjadi suatu keharusan bagi pemerintah dalam upaya meningkatkan pelayanan sesuai perkembangan teknologi informasi. Salah satu instansi pemerintah penyedia pelayanan publik yaitu Kelurahan Baratajaya kota Surabaya yang menjalankan inovasi Klampid new generation dalam menunjang peningkatan pelayanan administrasi kependudukan. Tujuan penelitian ini untuk mengukur keberhasilan inovasi Klampid new generation pada program kartu. identitas. Metode penelitian yang digunakan yaitu penelitian Kualitatif dengan teknik wawancara, observasi dan dokumentasi. Teori yang digunakan peneliti adalah Harvard school of government dengan indikator support/dukungan, capacity/kemampuan dan value/nilai. Hasil penelitian ini menunjukkan bahwa penerapan inovasi klampid new generation sudah berjalan dengan baik dalam pelayanan administrasi kependudukan di kelurahan Baratajaya, namun pada program Kartu Identitas Anak masih di temukan kendala yaitu kurangnya sosialisasi yang dilakukan oleh pemerintah baik dari Dispenduk, maupun dari pihak Kelurahan kepada masyarakat sehingga pengajuan menggunakan klampid new generation juga masih minim. Oleh karena itu inovasi klampid new generation pada program kartu identitas anak belum mencapai pelayanan prima.
The use of attractants in reducing the occurrence of the Prunus serotina (Ehrh.)
Authors: Baranowska Marlena , Szczepaniak Oskar , Meres Bartłomiej , Korzeniewicz Robert 
Published: June 2023

Abstract

Black cherry, which occurs in European forests, contributes to their distortion or degradation of native ecosystems. Therefore, measures are taken to reduce its occurrence. One of them is the biological method involving grazing animals.
The aim of this research was to develop and identify an attractant that would increase the attractiveness of black cherry as a feeding base for deer, which would limit its occurrence.
This research was carried out in Zielonka (17.10941 E 52.553975 N). In the experiment, 3-year-olds were used: Tilia cordata, Acer pseudoplatanus, A. platanoides, Fagus sylvatica and Prunus serotina. Before planting the seedlings, their height was measured. The control (K, 10 trees) consisted of trees of each species that were not sprayed with attractants. Another set of 10 trees were treated over the entire surface of the shoots with a bait mixture (MW), and the next 10 trees were sprayed with a 10% aqueous solution of NaCl. The attractant spraying was repeated six times. All damage observed was recorded. The inventoried tree damage was divided into four categories: 0%, no damage; I, 1–20% damaged trees; II, 21–50% damaged trees and III, more than 50% damaged trees.
The results of the Mann–Whitney U test (p = 0.0109), at the assumed level of significance (α = 0.05), showed that slightly higher seedlings were browsed.
These studies indicate the potential of using attractants as preparations influencing the palatability of the black cherry for deer. All recorded bites were classified as degree I damage. The trees were gnawed by fallow deer, 35.33% of trees were not damaged by game at all, and 64.66% of trees were damaged in degree I. In the case of sycamore maple, Norway maple and linden, the bait mixture did not increase the number of nibbled buds and leaves, while NaCl increased the attractiveness of beech and black cherry as a feeding base.
Conducting further research studies on the improvement of preparations may give a chance to reduce the use of chemicals in forest protection and give the possibility of using attractants where it is impossible to use herbicides.