bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factores asociados a mortalidad en una cohorte de niños con neumonía asociada al ventilador en un hospital pediátrico latinoamericano
Authors: Naveda Romero Omar Eugenio 
Published: May 2023

Antecedentes: teniendo presente que la neumonía asociada al ventilador (NAV) es la segunda infección más frecuente asociada al cuidado de la salud, resulta importante identificar los factores relacionados con su mortalidad, más aún en países con recursos limitados. Objetivo: determinar factores de riesgo para mortalidad por NAV. Métodos: estudio de cohorte simple prospectivo realizado entre enero 2017 y diciembre 2020 que incluyó niños entre 1 mes y 14 años. Se relacionaron variables demográficas, gravedad en la admisión, tipo de NAV, gérmenes causales, indicaciones de ventilación, comorbilidades e intervenciones médicas con mortalidad por NAV. El diagnóstico de NAV fue realizado con base a la definición del CDC del 2013. Resultados: un total de 46 niños con NAV fueron incluidos en el análisis. La mortalidad fue del 34.8 %. Los factores asociados a mortalidad fueron: pSOFA (Pediatric Sequential Organ Failure Assesment Score) en las primeras 24 horas de admisión mayor de 7 puntos (3.3 % vs. 50 %; OR: 29,0 IC-95 % [3,1 – 267,4]; p < 0.0001), infección por Enterobacter cloacae (3.3 % vs. 37.5 %; OR: 17.1; IC-95 % [1,9 – 162,7]; p = 0.002) y TAV (traqueobronquitis asociada al ventilador) (16.7 % vs. 50 %; OR: 5.0; IC-95 % [1.3 – 19.7]; p = 0.017]. También resultaron asociados: shock, SDMO (síndrome de disfunción multiorgánica) y sepsis. Conclusiones: pSOFA, infección por Enterobacter cloacae, TAV, shock, SDMO y sepsis fueron identificados como variables asociadas a mortalidad en niños con NAV.
Wakaf Literation to Appear An Interference in Mentify for Milenial: Implementation for Students in Madrasah Aliyah State 4 Bantul
Authors: Saputri Eva Nopalasari , Latifah Halim Pandu , Almunawir Al Virizky Arjunitha , Fuadi Fahmi Hasan , Nisa Ayu Himatun , Akbar Maulana Ali , Setiawan Alfan Rois , Safitri Afirsta Dyah Mega , Pratiwi Inayah Nadhira , Saripudin Ajis , Rizqi Anis Fathul 
Published: May 2023

Community service is carried out by conducting endowment socialization for high school / MA students in order to foster social awareness through endowments, bearing in mind that the community's understanding of endowment is only synonymous with parents and those who have wealth. Through waqf literacy with waqf tests strategies aimed at assessing students' understanding of waqf, fostering interest in waqf among students or the community itself, creating students and communities who are socially aware through waqf. This method of socialization uses the method of direct teaching patterns, questions and answers, and assignments or tests. The socialization participants consisted of 33 students from class XI IPS MAN 4 Bantul. The total number of pre-test and post-test questions is 10 questions that are true or false. Where each question has 10 points. From the results of the pre-test evaluation, an average value of 59.39 was obtained with a vulnerable value of 30-70 and the results of the post-test evaluation obtained an average value of 81.21 with a vulnerable value of 70-100. The results of the overall evaluation there was a significant increase in value of 21.82, the results showed the method was considered quite useful in terms of grades and enthusiasm of the students. Apart from that, there are a number of questions that show that students are truly enthusiastic about endowments.Keywords: waqf literacy, readability, waqf
Significant elevated CXCL14 and decreased IL-39 levels in patients with tuberculosis
Authors: Ding Min , Wang Hong-xu , Gao Si-jia , Lai Xiao-fei , Li An-long , Bao Jia-jia , Hosyanto Felycia-Fernanda , Xu Lei 
Published: May 2023

Abstract
To explore the serum levels of IL-39, CXCL14, and IL-19 in patients with tuberculosis (TB) along with their clinical significances and their concentration changes in macrophages after Bacille Calmette-Guérin vaccine (BCG) or Mycobacterium tuberculosis (M. tb) H37Rv stimulation in vitro. The serum levels of IL-39, CXCL14, and IL-19 of 38 TB patients, and 20 healthy staff members were measured by enzyme-linked immunosorbent assay. Moreover, the levels of IL-19, CXCL14, and IL-39 in cultured THP-1 macrophages were detected at 12, 24, and 48 h after stimulation with BCG or M. tb H37Rv strains. It was found the serum level of IL-39 was significantly reduced and CXCL14 was remarkably elevated in TB patients. In vitro, at 48 h after stimulation, IL-39 level of cultured THP-1 macrophages in the H37Rv group was significantly lower than that in the BCG and control groups, and the CXCL14 level of cultured THP-1 macrophages in the H37Rv stimulation group was remarkably higher than that in the control group. Therefore, IL-39 and CXCL14 may be involved the pathogenesis of TB, and serum IL-39 and CXCL14 could potentially serve as a new biomarker of TB.
Gemella morbillorum infective endocarditis: A case report and literature review
Authors: Cao Xuejie , Yuan Lichao 
Published: May 2023

Abstract
Infective endocarditis (IE) caused by Gemella morbillorum is rare. Consequently, little is known about the natural course of endocarditis caused by this pathogen. This report describes the case of a 37-year-old male patient with G. morbillorum endocarditis. The patient was hospitalized for a fever of unknown origin. He complained of intermittent fever of unknown origin for 2 months. He had also undergone root canal therapy for pulpitis a month ago. After admission, the infectious pathogen G. morbillorum was identified using metagenomic next-generation sequence technology. The anaerobic blood culture bottle showed only Gram-positive cocci. Transthoracic echocardiography showed 10 mm vegetation on the aorta, which met the IE diagnostic Duke’s criteria, and the patient was diagnosed with G. morbillorum IE. Because no bacterial colonies were formed on the culture, the drug sensitivity test could not be conducted. Ceftriaxone anti-infective drugs are based on careful consideration of the literature and patient. Six days after antibiotic treatment in our department, the patient was discharged from the hospital in stable condition and had no adverse reactions at 1 week of follow-up. To help clinicians better understand the disease of G. morbillorum IE, we also reviewed and discussed the relevant cases published after 2010 when presenting the report.
Twinned single crystal structure of Li4P2S6
Authors: Ben Yahia Hamdi , Motohashi Kota , Mori Shigeo , Sakuda Atsushi , Hayashi Akitoshi 
Published: May 2023

Abstract
Yellow needles-like single crystals of Li4P2S6 were obtained serendipitously during the preparation of Li7P3S10O. The twinned crystal structure of Li4P2S6 was determined from single-crystal X-ray diffraction data [wR(F
2) = 0.069, 716 reflections, 40 variables]. Li4P2S6 crystallizes in the trigonal system, space group

P

3
‾

m
1

$P\overline{3}m1$

(N° 164), a = 10.5042(8) Å, c = 6.5837(6) Å, V = 629.11(9) Å3 and Z = 2. The lithium octahedra form a [Li4S6]8− honeycomb-like structure within which diphosphate units are located. The comparison of our crystal structure to those of P63/mcm-,

P

3
‾

1
m

$P\overline{3}1m$

-, and P321-Li4P2S6 demonstrated group-subgroup relationships and associated the disorder or order of the phosphorus atoms within the identical [Li4S6]8− 3d-frameworks to the choice of the unit cell (the subcell with a ∼ 6.07 Å vs. the supercell with a ∼ 10.5 Å).
Diagnosis of 17-alpha hydroxylase deficiency performed late in life in a patient with a 46,XY karyotype
Authors: Bouça Bruno , Cascão Mariana , Fiúza Pedro , Amaral Sara , Bogalho Paula , Silva-Nunes José 
Published: May 2023

Summary
17-Alpha-hydroxylase deficiency (17OHD) is a rare autosomal recessive disease, representing 1% of cases of congenital adrenal hyperplasia. A 44-year-old female presented to the emergency department complaining of generalized asthenia and polyarthralgia for about 2 weeks. On examination, she was hypertensive (174/100 mmHg), and laboratory results revealed hypokalemia and hypocortisolism. She had an uncharacteristic morphotype, BMI of 16.7 kg/m2, cutaneous hyperpigmentation, and Tanner stage M1P1, with normal female external genitalia. She reported to have primary amenorrhea. Further analytical evaluations of her hormone levels were performed CT scan revealed adrenal bilateral hyperplasia and absence of female internal genitalia. A nodular lesion was observed in the left inguinal canal with 25 × 10 mm, compatible with a testicular remnant. Genetic analysis identified the c.3G>A p.(Met1?) variant in homozygosity in the CYP17A1 gene, classified as pathogenic, confirming the diagnosis of 17OHD. Karyotype analysis was compatible with 46,XY. The association of severe hypokalemia, hypertension, hypocortisolism, and oligo/amenorrhea and the absence of secondary sexual characteristics favored the diagnosis of 17OHD, confirmed by genetic testing. As in other published clinical cases, diagnosis outside pediatric age is not rare and should be considered when severe hypokalemia occurs in hypertensive adults with a lack of secondary sexual characteristics.

Learning points

The association of severe hypokalemia, hypertension, hypocortisolism, and oligo/amenorrhea and the absence of secondary sexual characteristics favor the diagnosis of 17-alpha-hydroxylase deficiency (17OHD).

Diagnosis outside pediatric age is not rare.

17OHD should be considered when severe hypokalemia occurs in hypertensive adults with a lack of secondary sexual characteristics.
Longitudinal Health Status and Quality of Life in Congenital Diaphragmatic Hernia
Authors: Sreeram Isabel I. , Schnater Johannes M. , van Rosmalen Joost , Cochius-den Otter Suzan C.M. , Peters Nina C.J. , Rottier Robbert J. , Gischler Saskia J. , Wijnen René M.H. , IJsselstijn Hanneke , Rietman André B. 
Published: May 2023

OBJECTIVES
To longitudinally evaluate self-reported health status (HS) and quality of life (QoL) in 8- and 12-year-old survivors of congenital diaphragmatic hernia (CDH). We hypothesized that HS would improve with age—as associated health problems tend to decline—whereas QoL would decrease, as the children start to compare themselves with peers.

METHODS
Self-reported HS and QoL of 133 children born between 1999 and 2013 who had joined our standardized follow-up program were routinely assessed at the ages of 8 and 12 with generic, internationally validated, standardized instruments. Longitudinal evaluation of total and subscale scores was performed using general linear model analyses. In addition, we compared these scores to sex- and age-specific normative data.

RESULTS
Between ages 8 and 12, boys born with CDH perceived a decline in HS (mean difference −7.15, P &lt; .001). Self-reported QoL did not change over time in both boys and girls. At both ages, HS was significantly lower than that of healthy peers (effect size = 0.71, P = .001 for boys, and effect size = 0.69, P = .003 for girls), whereas differences in QoL were small.

CONCLUSIONS
Children born with CDH are at risk for declining HS between 8 and 12 years, but not QoL, compared with healthy peers. Given that children born with CDH tend to grow into deficits, our findings highlight the need for continued somatic and psychological assessments in adolescent and adult CDH survivors.
NUSAP1 regulates basal cell carcinoma migration, invasion and DNA damage through activation of the Hedgehog signaling pathway
Authors: Zhu Yanjun , Liu Yan , Zhang Liwen , Zeng Shihua , Xu Wen 
Published: May 2023

AbstractBackgroundBasal cell carcinoma (BCC) is a prevalent cutaneous cancer with an increasing incidence. Nucleolar and spindle associated protein 1 (NUSAP1) is a cell proliferation-related protein that participates in the development of various cancers. However, its role and mechanism in BCC remain elusive.MethodsThe expression of NUSAP1 was detected by western blot. Gain- and loss-of-function assays were performed through the transfection of overexpression plasmid of NUSAP1 and si NUSAP1 into TE354.T cells. The role and mechanism of action of NUSAP1 in BCC were explored by cell counting kit-8 (CCK-8), colony formation, transwell, flow cytometry and western blot assays.ResultsNUSAP1 was highly expressed in TE354.T cells. Overexpression of NUSAP1 enhanced cell viability, colony forming numbers, numbers of migrated and invasive cells and the relative protein expression of RAD51, but reduced the apoptosis rate and the relative protein expression of γH2AX in TE354.T cells. Inverse results were obtained in these indicators after TE354.T cells were downregulated with NUSAP1. Moreover, the relative expression of proteins involved in the Hedgehog signaling pathway was increased by transfection of the overexpression plasmid of NUSAP1 into TE354.T cells, but decreased by the transfection of si NUSAP1 into TE354.T cells.ConclusionBoth gain- and loss-of-function results revealed that NUSAP1 promoted proliferation, migration and invasion but attenuated apoptosis and DNA damage in BCC, which was involved in the activation of the Hedgehog signaling pathway.
T.V. PheroLure® : Volatile emission by semiochemical lures and the impact thereof on the volatile profile of a commercial tomato field
Authors: Van Tonder Aletta J , Nortjé Gerhardus P , Botha Ben M 
Published: May 2023

Pheromone-based or semiochemical lures for insect detection and monitoring in agriculture is common practice. Many countries exempt these devices from regulatory requirements, but not South Africa. The question arises whether the pheromone/semiochemical lures influence the naturally occurring compounds significantly, to justify concern for human toxicity and ecotoxicity. T.V. PheroLure® is a novel five-component lure developed by Insect Science (Pty) Ltd. used for monitoring African bollworm, Helicoverpa armigera (an important insect pest on tomatoes). T.V. PheroLure® is a volatile organic compound (VOC) blend impregnated in a polyethylene bulb. The influence of T.V. PheroLure® on the volatile profile of a tomato field was evaluated in a commercial growing area of South Africa. Tomato VOCs were collected before, during and after the application of six T.V. PheroLures® in yellow bucket funnel traps randomly distributed over 1 ha. VOCs were collected from planting until harvest (22 weeks) at five randomly selected sites. Collection also took place in adjacent tomato fields where no T.V. PheroLure® was applied. The constituents of T.V. PheroLure® had no significant influence on the naturally occurring VOCs observed in the tomato field. The results suggest that the concern for toxicity and ecotoxicity is unjustified when using semiochemical devices for monitoring purposes. The natural physiology of the plant, rather than T.V. PheroLure®, influenced the VOCs observed in a tomato field.
A prospective interventional study to observe the effectiveness of parenteral iron infusion of iron isomaltoside 1000 (Fur – IV) in obstetrics and gynecology patients suffering from moderate to severe iron deficiency anaemia
Authors: Shah Ishan P , Pandya Manish , Kadikar Bhamini , Nimbalkar Pankaj , Patel Tejas 
Published: May 2023

Anaemia during pregnancy is allied with maternal and foetal complications like increased risk of intrauterine growth retardation, prematurity, low birth weight, and maternal and infant mortality. The agent iron isomaltose 1000 (Fur-IV) combines iron and isomaltose 1000 for slow, controlled release to reduce the risk of free iron toxicity and provide flexibility and convenience for high dose administration. Iron isomaltoside has been shown to be effective in the treatment of IDA in many treatment groups compared to intravenous iron sucrose and FCM. : It is a prospective interventional study which is conducted to observe an increase in hemoglobin levels in obstetric and gynecological department patients suffering from IDA in whom oral iron preparation was ineffective or in case of clinical need to supply iron rapidly via single infusion of iron isomaltoside 1000. Each patient in the study received 500 mg single intravenous infusion. After this, patient was followed up and haemogram was repeated after 15 and 30 days of infusion while investigation for serum ferritin and serum iron was repeated after 30 days. Average Hb concentration in increased by 30.86% to 9.88 g/dL after 30 days of infusion. There is statistically significant difference between baseline values and post infusion 30 days values for serum ferritin and serum iron (p-value &#60;0.0001 for both).IV iron isomaltoside administration was well tolerated in patients with gynecological IDA who were intolerant or unresponsive to oral iron therapy or who required rapid iron administration.
Efficacy of N acetylcysteine vs metformin on biochemical and clinical parameters in women with polycystic ovarian syndrome in a tertiary care hospital
Authors: Gopalan Ushadevi , Gopalsamy Praveena 
Published: May 2023

: Ovarian dysfunction syndrome, or PCOS, is characterised by hyperandrogenism, enlarged cystic ovaries, and persistent anovulation in women of reproductive age. These coexist with insulin resistance, dyslipidemia, and obesity. To enhance menstruation pattern, insulin sensitivity, and treat dyslipidemia, a metformin replacement that has few side effects is required.: To study the effects of N acetyl cysteine in women with PCOS in and compare with commonly used Metformin. : To evaluate if N acetyl cysteine can substitute Metformin in treatment of women with PCOS in clinical parameters like BMI, menstrual pattern and biochemical parameters like FBS and lipid profile.: A prospective randomized control study was conducted in Obstetrics and Gynaecology department in Shri Sathya Sai medical college. 60 women (diagnosed by Rotterdam criteria) of age group 18 to 45 were included in this study. Subjects were randomly assigned into 2 groups. Group M received Metformin 500mg TDS and group N received N acetylcysteine 600mg TDS. Clinical and biochemical parameters contributing to metabolic syndrome such as menstrual pattern, BMI, Fasting blood sugars and lipid profile were noted before and after completion of the study along with side effects of the drugs.: 30 women in metformin group and 30 in NAC group completed study. A statistically significant decrease in BMI, Waist hip ratio was noted in both metformin and NAC groups. The mean difference post treatment was (3.63 vs 4.16) in BMI and (0.014 vs 0.017) in waist hip ratio. Both treatments led to significant improvement in menstrual pattern, FBS and lipid profile. Group N showed statistically better results compared group M. : Metformin and N acetyl cysteine were efficient in improving BMI, menstrual pattern and the metabolic parameters. However, decrease in BMI, WHR, FBS, lipid profile and menstrual pattern were statistically more significant in NAC compared to metformin.
A retrospective analysis of clinicopathological profile and compliance of locally advanced carcinoma cervix patients in the coastal region of Andhra Pradesh, India
Authors: Matta Venkata Ravi Teja , Manam Surendra , Anandarao P B 
Published: May 2023

Cancer of the cervix is the most common genital tract malignancy in the female and is a major public health problem in developing countries. Study of the sociodemographic data, clinical profile and compliance of patients is the first step in planning preventive measures and treatment facilities.The aims of the study were to determine the sociodemographic data and clinical profile, prognostic factors, compliance to concurrent chemo radiation of cervical cancer patients and study their association with other tumor-related factors.Our study is a record-based retrospective study from a single institution. The data of sociodemographic and clinical factors of 175 cervical cancer patients visited and their compliance to treatment were analyzed over a 2-year period. Data were analyzed using descriptive statistics.The mean age at presentation in our study is 54.8 years. The patients presented with bleeding per vagina as the most common presenting complaint i.e. 42.28%.38.88% patients presented with both bleeding per vagina and white discharge per vagina and 18.85% patients presented with white discharge per vagina.21.14% presented with symptoms less than 1 month, 52 patients presented with symptoms 1to 3 months duration. 49.14% presented with symptoms &#62;3months. In our study, 62.85% patients were married at age &#60; 17&#62; 17 years. squamous cell carcinoma is the most common histology in our study accounting for 85.71% followed by adenocarcinoma 11.42% other histoligies accounted for 2.85%.87.42% were grade 2 histologies. Stage IIB is the most common stage of presentation our study 47.4%. 86.28% patient are compliant with planned treatment (external beam radiotherapy +brachy therapy, 4.57% patients defaulted prior to the start of treatment, 3.42% patients defaulted during external beam radiotherapy, 15.71% defaulted for brachytherapy out of 151 patients who completed planned treatment, 80.79% patients received 5-6 cycles of concurrent ciplatin 40mg/m 2.11.92% were lost to follow up at the end of 1 year.Cervical cancer is a debilitating illness seen to affect mainly elderly women. Late presentation is still the norm, as majority of the patients presented with advanced disease at the time of diagnosis and were treated with radical radiotherapy, with or without chemotherapy. Compliance during treatment was good comparable to the other studies. The response and complication rates were comparable with other datasets. Further, the scope of studying socio-demographic factors is not limited to hospital services, and this information can also be utilized while making public health policies and implementation of cervical cancer control programs.
DISCURSIVE EVENT "APPOINTMENT TO A POSITION": THE SPECIFICS OF THE ARCHITECTONICS OF THE OFFICIAL DOCUMENT
Authors: Levchenko Marina N. 
Published: May 2023

Aim. To interpret the specifics of the architectonics of an official document with a discursive event “appointment to a position” in German, English and Russian.Methodology. The analysis of the claimed discursive event is carried out using descriptive and comparative methods, as well as by analyzing the structure and interpreting information in an official document when decomposing it into its constituent parts for their further interpretation.Results. The discourse analyzed in three languages is characterized by a similar situation, content and the same goal setting. Discursive architectonics, the number of participants in the “appointment to a position” event coincide in the languages studied. However, there are differences in the use of emotionally expressive vocabulary in the discourses of German and English, and it is completely absent in the Russian-language discourse. This indicates the existence of typological features of the official document “appointment to a position”, regardless of the language, as well as the individual linguistic features of each of the presented discourses.Research implications. The results obtained are important for various branches of the science of language: Text Theory, Text Interpretation, Text Typology. Using these results will be important for the training of linguists, especially in terms of familiarizing them with the latest requirements and features in the field of written business communication.