bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exciting spiral arms in protoplanetary discs from flybys
Authors: Smallwood Jeremy L , Yang Chao-Chin , Zhu Zhaohuan , Martin Rebecca G , Dong Ruobing , Cuello Nicolás , Isella Andrea 
Published: March 2023

ABSTRACT
Spiral arms are observed in numerous protoplanetary discs. These spiral arms can be excited by companions, either on bound or unbound orbits. We simulate a scenario where an unbound perturber, i.e. a flyby, excites spiral arms during a periastron passage. We run three-dimensional hydrodynamical simulations of a parabolic flyby encountering a gaseous protoplanetary disc. The perturber mass ranges from $10\, \rm M_J$ to $1\, \rm {\rm M}_{\odot }$. The perturber excites a two-armed spiral structure, with a more prominent spiral feature for higher mass perturbers. The two arms evolve over time, eventually winding up, consistent with previous works. We focus on analysing the pattern speed and pitch angle of these spirals during the whole process. The initial pattern speed of the two arms are close to the angular velocity of the perturber at periastron, and then it decreases over time. The pitch angle also decreases over time as the spiral winds up. The spirals disappear after several local orbital times. An inclined prograde orbit flyby induces similar disc substructures as a coplanar flyby. A solar-mass flyby event causes increased eccentricity growth in the protoplanetary disc, leading to an eccentric disc structure which dampens over time. The spirals’ morphology and the disc eccentricity can be used to search for potential unbound stars or planets around discs where a flyby is suspected. Future disc observations at high resolution and dedicated surveys will help to constrain the frequency of such stellar encounters in nearby star-forming regions.
Estimating dust temperature and Far-IR luminosity of high-redshift galaxies using ALMA single-band continuum observations
Authors: Fudamoto Y , Inoue A K , Sugahara Y 
Published: March 2023

ABSTRACT
We present a method that derives the dust temperatures and infrared (IR) luminosities of high-redshift galaxies assuming radiation equilibrium in a simple dust and stellar distribution geometry. Using public data from the Atacama Large Millimeter/submillimeter Array (ALMA) archive, we studied dust temperatures assuming a clumpy interstellar medium (ISM) model for high-redshift galaxies, then tested the consistency of our results with those obtained using other methods. We find that a dust distribution model assuming a clumpiness of ${\rm log}\, \xi _{\rm clp}=-1.02\pm 0.41$ may accurately represent the ISM of high-redshift star-forming galaxies. By assuming a value of ξclp, our method enables the derivation of dust temperatures and IR luminosities of high-redshift galaxies from dust continuum fluxes and emission sizes obtained from single-band ALMA observations. To demonstrate the method proposed herein, we determined the dust temperature ($T_{\rm d}=95^{+13}_{-17}\, \rm {K}$) of a z ∼ 8.3 star-forming galaxy, MACS0416-Y1. Because the method only requires a single-band dust observation to derive a dust temperature, it is more easily accessible than multiband observations or high-redshift emission line searches and can be applied to large samples of galaxies in future studies using high-resolution interferometers such as ALMA.
Evolution of brightness and magnetic features of young solar-type stars – II. The young F8 star HIP 71933
Authors: Hughes J E , Marsden S C , Carter B D , Waite I A , Burton D M , Perugini G M , Hébrard E M 
Published: March 2023

ABSTRACT
The early, active history of our Sun is still not fully understood. Observations of the magnetic fields on active young solar-type stars allow us an insight into the early evolution of our Sun. Here we present Doppler and Zeeman–Doppler images of the young late-F star HIP 71933 (HD 129181) at multiple epochs to add to the growing data about the evolution of magnetic cycles in solar-type stars. Spectroscopic data were obtained over seven epochs spanning 10 yr of observations, with two epochs including spectropolarimetric data. The brightness maps at all epochs show a consistent spot activity in a non-uniform ring at a latitude of approximately +60° with no polar spot present in any epoch. The two magnetic field maps taken ∼2 yr apart show a strong poloidal field configuration with most of the poloidal field energy in the dipolar configuration. The magnetic maps show no evidence of a polarity reversal. We were able to measure the differential rotation from one of the seven epochs using the brightness data finding a dΩ of 0.325 ± 0.01 rad d−1. The values for the rotational period and differential rotation found for HIP 71933 are consistent with values found for other late-F or early-G stars. The dominant poloidal features and the limited spots at the pole are unusual for a rapidly rotating star but not unique.
Andromeda XXV – a dwarf galaxy with a low central dark matter density
Authors: Charles Emily J E , Collins Michelle L M , Rich R Michael , Read Justin I , Kim Stacy Y , Ibata Rodrigo A , Martin Nicolas F , Chapman Scott C , Balbinot Eduardo , Weisz Daniel R 
Published: March 2023

ABSTRACT
Andromeda (And) XXV has previously been reported as a dwarf spheroidal galaxy (dSph) with little-to-no dark matter. However, the uncertainties on this result were significant. In this study, we nearly double the number of member stars and re-derive the kinematics and mass of And XXV. We find that And XXV has a systemic velocity of νr = −107.7 ± 1.0 kms−1 and a velocity dispersion of $\sigma _{\rm \nu }=3.7^{+1.2}_{-1.1}$ kms−1. With this updated velocity dispersion and a new literature measurement of the radial surface brightness profile, we derive a mass contained within the half-light radius of $M(r\lt r_{\rm h})=4.7^{+3.0}_{-2.9}\times 10^6$ M⊙. This mass corresponds to a mass-to-light ratio of $\text{[M/L]}_{\rm r_{h}}=25^{+17}_{-16}$ M⊙/L⊙, demonstrating that And XXV is most-likely dark matter dominated. We also measure the metallicity of And XXV to be $\rm [Fe/H]=-1.9\pm 0.1$ dex, which is in agreement with previous results. Finally, we extend the analysis of And XXV to include mass modelling using GravSphere. We find that And XXV has a low central dark matter density, ρDM(150 pc) = $2.3^{+1.4}_{-1.1}\times 10^7$ M⊙ kpc−3, which makes And XXV a clear outlier when compared to other local group dSphs of the similar stellar mass. In a companion paper, we will explore whether some combination of dark matter cusp-core transformations and/or tides can explain And XXV’s low density.
Comprehensive Genomic Profiling of NF2-Mutated Kidney Tumors Reveals Potential Targets for Therapy
Authors: Hacking Sean M , Pavlick Dean , Wang Yihong , Carneiro Benedito A , Mullally Matthew , Lu Shaolei , Canepa Mariana , Bratslavsky Gennady , Jacob Joseph , Necchi Andrea , Spiess Philippe E , Wang Li , Yakirevich Evgeny , Ross Jeffrey 
Published: March 2023

Abstract
Genomic alterations (GA) in NF2 tumor-suppressor gene have been associated with aggressive behavior in kidney tumors. We used comprehensive genomic profiling (CGP) to evaluate the frequencies of NF2 GA in histologic subtypes of kidney tumors and co-occurring GA in other genes and biomarkers. Advanced kidney tumors included 1875 clear cell (ccRCC), 405 papillary (pRCC), 108 chromophobe (chRCC), 171 sarcomatoid (sRCC), 61 collecting duct (cdRCC), 49 medullary (mRCC), 134 unclassified (uRCC), 906 urothelial carcinoma of renal pelvis (UC), and 147 Wilms tumors underwent hybrid-capture based CGP to evaluate all classes of GA. 192 (4.9%) of kidney tumors featured NF2 GA which were predominantly structural variant mutations (89%), followed by copy number alterations (9%). Gender and age were similar between NF2-mutant (NF2mut) and NF2-wild type (NF2wt) cohorts with male preponderance. NF2 GA frequency was highest in cdRCC (30%), sRCC (21%), uRCC (15%), and pRCC (12%) while lowest in ccRCC (3%), UC (3%) Wilms tumor (1%), and chRCC (0%). NF2 mutational status was associated with loss of Ch 22 (P &lt; .001). NF2mut RCC harbored co-occurring GA including CDKN2A, CDKN2B, SETD2, and BAP1. VHL, PBRM1, PTEN, and FGFR3 GA were significantly more frequent in NF2wt than in NF2mut tumors. MTOR pathway GAs were uncommon in NF2mut tumors. No NF2 mutated RCC featured MSI-high or high TMB. sRCC was associated with high PD-L1 expression. PD-L1 SP142 tumoral (P = .04) and immune cells (P = .013) were more frequent in NF2mut as compared to NF2wt group. Among histologic subtypes of RCC, cdRCC, sRCC, pRCC, and uRCC are enriched in NF2 GA. Co-occurrent GA in CDKN2A/B, SETD2, and BAP1 may represent potential therapeutic targets. Higher level of PD-L1 expression in NF2mut cohort suggests that these tumors might be sensitive to immune checkpoint inhibitor therapies.
An all ambient, room temperature–processed solar cell from a bare silicon wafer
Authors: Okamoto Kazuya , Fujita Yutaka , Nishigaya Kosuke , Tanabe Katsuaki 
Published: March 2023

Abstract
Solar cells are a promising optoelectronic device for the simultaneous solution of energy resource and environmental problems. However, their high cost and slow, laborious production process so far severely hinder a sufficient widespread of clean, renewable photovoltaic energy as a major alternative electricity generator. This undesirable situation is mainly attributed to the fact that photovoltaic devices have been manufactured through a series of vacuum and high-temperature processes. Here we realize a poly(3,4-ethylenedioxythiophene)–poly(styrenesulfonate) (PEDOT:PSS)/Si heterojunction solar cell fabricated only in ambient and room temperature conditions from a plain Si wafer, with an over 10% energy conversion efficiency. Our production scheme is based on our finding that PEDOT:PSS photovoltaic layers actively operate even on highly doped Si substrates, which substantially mitigates the condition requirements for electrode implementation. Our approach may pave the way for facile, low-cost, high-throughput solar cell fabrication, useful in various fields even including developing countries and educational sites.
On Bitcoin: A Study in Applied Metaphysics
Authors: Lipman Martin A 
Published: March 2023

AbstractThis essay is dedicated to the memory of Katherine Hawley.1Bitcoin was invented to serve as a digital currency that demands no trust in financial institutions, such as commercial and central banks. This paper discusses metaphysical aspects of bitcoin, in particular the view that bitcoin is socially constructed, non-concrete, and genuinely exists. If bitcoin is socially constructed, then one may worry that this reintroduces trust in the communities responsible for the social construction. Although we may have to rely on certain communities, I argue that social construction doesn’t imply a demand for trust because the relevant communities don’t take on any relevant commitments. Bitcoin is indeed trust-free.
EFFECT OF ABDOMINAL IRRADIATION IN MICE MODEL OF INFLAMMATORY BOWEL DISEASE
Authors: Kang Sohi , Son Yeonghoon , Shin In-Sik , Moon Changjong , Lee Min Y , Lim Kyung S , Park Su-Jin , Lee Chang-Geun , Jo Wol S , Lee Hae-June , Kim Joong S 
Published: March 2023

Abstract
Inflammatory bowel diseases could be diagnosed in major measure by diagnostic imaging; however, radiation exposure in the intestine may also contribute to the progression of these pathologies. To better understand the impact of radiation in the presence of bowel disease, we administered dextran sodium sulfate (DSS) to C57BL/6 mice to induce colitis and exposed to radiation at abdominal area. We observed that abdominal irradiation (13 Gy) aggravates the DSS-induced decrease in survival rate (0%), body weight (74.54 ± 3.59%) and colon length (4.98 ± 0.14 cm). Additionally, abdominal irradiation markedly increased in colonic inflammation levels (3.16 ± 0.16) compared with that of DSS-induced sham mice. Furthermore, abdominal irradiation also increased the mRNA expression levels of inflammatory genes, such as cyclooxygenase-2 (13.10 folds), interleukin-6 (48.83 folds) and tumor necrosis factor-alpha (42.97 folds). We conclude that abdominal irradiation aggravates the detrimental effects of DSS-induced colitis in mice, which might be a useful guideline for inflammatory bowel disease patients.
Changing face-to-face to online radiation protection training: experiences of trainers and trainees
Authors: Clarijs Tom , Belmans Niels , Van Puyvelde Lisanne , Coeck Michèle 
Published: March 2023

Abstract
The SCK CEN Academy for Nuclear Science and Technology functions as the umbrella structure coordinating the education and training activities of the Belgian Nuclear Research Centre (SCK CEN). One of the main activities of the SCK CEN Academy is to provide customised training to professionals working in the nuclear industry, healthcare, research or governmental institutions. The courses and practical sessions are usually given in a face-to-face (FTF) format. This has drastically changed in the last 2 y because of the COVID-19 pandemic when it was necessary to switch course delivery from FTF to an online format. Feedback was collected from trainees and trainers in different training courses in radiation protection provided in FTF and online format. The analysis of this feedback allows training providers to make better-informed decisions on the best-suited training format depending on the content, target audience and the duration of the learning activity.
Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial
Authors: Susai Subash Raj , Föcking Melanie , Mongan David , Heurich Meike , Coutts Fiona , Egerton Alice , Whetton Tony , Winter-van Rossum Inge , Unwin Richard D , Pollak Thomas A , Weiser Mark , Leboyer Marion , Rujescu Dan , Byrne Jonah F , Gifford George W , Dazzan Paola , Koutsouleris Nikolaos , Kahn René S , Cotter David R , McGuire Philip 
Published: March 2023

AbstractBackground and HypothesisTreatment response to specific antipsychotic medications is difficult to predict on clinical grounds alone. The current study hypothesizes that the baseline complement pathway activity predicts the treatment response and investigates the relationship between baseline plasma biomarkers with treatment response to antipsychotic medications.Study DesignBaseline plasma samples were collected from first episode of psychosis patients (n = 243) from a multi-center clinical trial. The participants were treated with amisulpride for 4 weeks. Levels of complement and coagulation proteins at baseline were measured using both data-dependent and data-independent mass spectrometry approaches. The primary outcome was remission status at 4 weeks and the secondary outcomes included change in psychotic and functional symptoms over the period of treatment. In addition, immunoassays were performed at baseline for complement C1R, as well as for activation markers C4a and sC5b-9.Study ResultsThe plasma level of complement variant C4A was significantly associated with remission at 4 weeks. Moreover, higher levels of several complement and coagulation pathway proteins were associated with a reduction in psychotic symptoms and an improvement in functioning. Immunoassays showed an association of baseline levels of C1R and C4a as well as complement activation marker sC5b-9 levels with treatment response.ConclusionThe results demonstrated that the response to antipsychotic treatment might be related to pre-treatment levels of plasma complement and coagulation pathway proteins. This is consistent with independent evidence associating immune dysfunction with the pathophysiology of psychosis. Moreover, these results inform the development of novel therapeutic approaches that target the complement system for psychosis.
Urban Crisis and Epidemic Typhus in Madrid at the Beginning of the Twentieth Century
Authors: de Miguel Salanova Santiago 
Published: March 2023

Summary
During the nineteenth century, epidemic typhus was one of the main public health problems resulting from industrialisation and urbanisation processes in Europe. It became an illness intricately linked to poverty, famine, the labour crisis and residential overcrowding. In Spain, it reached a significant peak in the first decade of the twentieth century, and Madrid was its uncontested epicentre. Between 1903 and 1910, the Spanish capital was hit by two waves of epidemic typhus. Their causes were associated with the fault lines drawn in the city’s structure during the previous decades. The origins of both epidemics, the resources deployed to control them and their socio-spatial spread can be linked to the gaps in urban policies in Madrid in comparison with the transformations that the city underwent after the middle of the nineteenth century.
A Modified Reverse Right-angled Triangle Osteotomy Using the Lateral Approach for the Treatment of Posttraumatic Cubitus Varus Deformity in Children
Authors: Liu Xiping , Liu Kun , Yang Jun 
Published: March 2023

Background:
Cubitus varus deformity is a complex 3-dimensional deformity. Various osteotomies have been introduced to correct this deformity, however, there is no consensus on the best procedure to correct the deformity while avoiding complications. In this retrospective study, we used a modified inverse right-angled triangle osteotomy to treat 22 children with posttraumatic cubitus varus deformity. The primary objective was to evaluate this technique by presenting its clinical and radiologic results.

Methods:
Twenty-two consecutive patients with a cubitus varus deformity underwent a modified reverse right-angled triangle osteotomy between October 2017 and May 2020 and were then followed for a minimum of 24 months. We evaluated its clinical and radiologic results. Functional outcomes were assessed using Oppenheim criteria.

Results:
The average follow-up period was 34.6 months (range, 24.0 to 58.1 months). The mean range of motion was 4.32 degrees (range, 0 degrees to 15 degrees)/122.73 degrees (range, 115 degrees to 130 degrees) (hyperextension/flexion) before surgery and 2.05 degrees (range, 0 degrees to 10 degrees)/127.27 degrees (range, 120 degrees to 145 degrees) at the final follow-up. There were significant (P < 0.05) differences between the flexion and hyperextension angles before surgery and at the final follow-up. Based on Oppenheim criteria, results were excellent for 20, good for 2, and none of the patients had poor results. The mean humerus-elbow-wrist angle improved from 18.23 degrees (range, 10 degrees to 25 degrees) varus preoperatively to 8.45 degrees (range, 5 degrees to 15 degrees) valgus postoperatively (P < 0.05). The mean of the preoperative lateral condylar prominence index was 3.52 (range, 2.5 to 5.2) and the average postoperative lateral condylar prominence index was −3.28 (range, −1.3 to −6.0). All patients were pleased with the overall appearance of their elbows.

Conclusions:
The modified reverse right-angled triangle osteotomy can precisely and stably correct the deformity in the coronal and sagittal planes, we recommend this technique as a simple, safe, and reliable correction of cubitus varus deformity.

Level of Evidence:
Level IV; case series; therapeutic studies—investigating the results of treatment.
Impact of baseline blood pressure on all-cause death in patients with atrial fibrillation: results from a multicenter registry study
Authors: Xu Wei , Song Qirui , Zhang Han , Wang Juan , Shao Xinghui , Wu Shuang , Zhu Jun , Cai Jun , Yang Yanmin 
Published: March 2023

Abstract

Background:
The ideal blood pressure (BP) target for patients with atrial fibrillation (AF) is still unclear. The present study aimed to assess the effect of the baseline BP on all-cause death in patients with AF.

Methods:
This registry study included 20 emergency centers across China and consecutively enrolled patients with AF from 2008 to 2011. All participants were followed for 1 year ± 1 month. The primary endpoint was all-cause death.

Results:
During the follow-up, 276 (13.9%) all-cause deaths occurred. Kaplan–Meier curves showed that a systolic blood pressure (SBP) ≤110 mmHg or >160 mmHg was associated with a higher risk of all-cause death (log-rank test, P = 0.014), and a diastolic blood pressure (DBP) <70 mmHg was associated with the highest risk of all-cause death (log-rank test, P = 0.002). After adjusting for confounders, the multivariable Cox regression model suggested that the risk of all-cause death was statistically increased in the group with SBP ≤110 mmHg (hazard ratio [HR], 1.963; 95% confidence interval [CI], 1.306–2.951), and DBP <70 mmHg (HR, 1.628; 95% CI, 1.163–2.281). In the restricted cubic splines, relations between baseline SBP or DBP and all-cause death showed J-shaped associations (non-linear P <0.001 and P = 0.010, respectively). The risk of all-cause death notably increased at a lower baseline SBP and DBP. The subgroup analyses were consistent with the main findings.

Conclusions:
Having a baseline SBP ≤110 mmHg or DBP <70 mmHg was associated with a significantly higher risk of all-cause death in patients with AF. An excessively low BP may not be an optimal target for patients with AF.
Health Care Avoidance Among Canadian Pilots Due to Fear of Medical Certificate Loss
Authors: Patel Parth K. , Hoffman William R. , Aden James , Acker Jason P. 
Published: March 2023

Objective
Canadian pilots may avoid health care and report inaccurate medical information due to fear of medical invalidation. We sought to determine if health care avoidance due to fear of certificate loss exists.

Methods
We conducted an anonymous 24-item Internet survey of 1405 Canadian pilots between March and May 2021. Responses were collected using REDCap, and the survey was advertised through aviation magazines and social media groups.

Results
Seventy-two percent of respondents (n = 1007) have felt worried about seeking medical care because it may impact their career or hobby. Respondents participated in various health care avoidance behaviors with the most common being having actually avoided or delayed medical care for a symptom (46%, n = 647).

Conclusion
Canadian pilots fear medical invalidation and consequently, avoid health care. This may be severely impacting aeromedical screening effectiveness.