bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Chinese medicine based integrated health interventions for depression: A systematic review and meta-analysis
Authors: Ruan Jiayin , Chen Shucheng , Liang Jiagui , Ho Fiona Yan Yee , Cheung Teris , Ho Janice Yuen Shan , Chan Wai Chi , Chen Haiyong , Au Dennis Cheuk Wing , Lee Rebecca Wing Yan , Mak Yim Wah , Yeung Wing Fai 
Published: March 2023

Abstract
Background: Some Traditional Chinese medicine (TCM)-based integrated health interventions have been used for depression, but pooled efficacy remains unknown.
Aims and objectives: This study aimed to systematically evaluate the efficacy of TCM-based integrated health interventions for relieving depression.
Design: Systematic review and meta-analysis.
Methods: A comprehensive literature search was conducted on 17 databases from inception up to June 2022. Randomized controlled trials (RCTs) that examined an integrated health intervention based on TCM theory for depression were included. The risk of bias was assessed using the second version of the Cochrane risk-of-bias tool for randomized trials, and the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation system.
Results: Eighteen RCTs with a total of 1,448 depressed participants were included. Health care providers, mainly nurses (14 studies), implemented TCM-based integrated health interventions. The pooled results showed that TCM-based integrated health interventions had larger effects on reducing depressive symptoms (15 studies; standardized mean difference = −2.05; 95% CI: −2.74, −1.37; p < 0.00001) compared with usual care at posttreatment but showed no significant difference contrasted to cognitive behavioral therapy (two studies, p = 0.31). However, the overall evidence was low.
Conclusions: The meta-analysis results indicated that TCM-based integrated health interventions were effective in reducing depression. However, the results should be interpreted with caution because of the low quality of the included studies. Future RCTs with rigorous designs should be conducted to provide robust evidence of the efficacy of TCM-based integrated health interventions in treating depression.
Robot-assisted radical prostatectomy following holmium laser enucleation of the prostate: Perioperative, functional, and oncological outcomes
Authors: Banno Taro , Nakamura Kazutaka , Ozaki Akihiko , Kouchi Yukiko , Ohira Tadashi , Shimmura Hiroaki 
Published: March 2023

Abstract
Robot-assisted radical prostatectomy with previous holmium laser enucleation of the prostate is challenging, and few studies have analyzed its perioperative, functional, and oncological outcomes. Here we retrospectively evaluated 298 robot-assisted radical prostatectomies, including 25 with and 273 without previous holmium laser enucleation of the prostate, performed in 2015–2022. Regarding perioperative outcomes, operative and console times were significantly longer in the previous holmium laser enucleation of the prostate group. In contrast, the estimated blood loss was similar between groups, and there were no transfusions or intraoperative complications. Multivariable Cox hazard regression analysis of the functional outcomes of postoperative urinary continence showed that body mass index, intraoperative bladder neck repair, and nerve sparing were independently associated factors, whereas a history of holmium laser enucleation of the prostate was not. Similarly, a history of holmium laser enucleation of the prostate was not associated with biochemical recurrence; however, positive surgical margins and seminal vesicle invasion were independent risk factors of biochemical recurrence. Our findings revealed that robot-assisted radical prostatectomy after holmium laser enucleation of the prostate was safe and raised no concerns of postoperative urinary incontinence or biochemical recurrence. Therefore, robot-assisted radical prostatectomy may be a treatment option for patients with prostate cancer after holmium laser enucleation of the prostate.
Impaired ATF3 Signaling Involves SNAP25 in SOD1 Mutant ALS Patients
Authors: Yazar Volkan , Kühlwein Julia K. , Knehr Antje , Grozdanov Veselin , Ekici Arif B. , Ludoplph Albert C. , Danzer Karin M. 
Published: March 2023

Abstract
Epigenetic remodeling is emerging as a critical process for several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). Genetics alone fails to explain the etiology of ALS, the investigation of the epigenome might therefore provide novel insights into the molecular mechanisms of the disease. In this study, we interrogated the epigenetic landscape in peripheral blood mononuclear cells (PBMCs) of familial ALS (fALS) patients with either chromosome 9 open reading frame 72 (C9orf72) or superoxide dismutase 1 (SOD1) mutation and aimed to identify key epigenetic footprints of the disease. To this end, we used an integrative approach that combines chromatin immunoprecipitation targeting H3K27me3 (ChIP-Seq) with the matching gene expression data to gain new insights into the likely impact of blood-specific chromatin remodeling on ALS-related molecular mechanisms. We demonstrated that one of the hub molecules that modulates changes in PBMC transcriptome in SOD1-mutant ALS patients is ATF3, which has been previously reported in an SOD1G93A mouse model. We also identified potential suppression of SNAP25, with impaired ATF3 signaling in SOD1-mutant ALS blood. Together, our study shed light on the mechanistic underpinnings of SOD1 mutations in ALS.
Efficacy and safety of robot-assisted laparoscopic myomectomy versus laparoscopic myomectomy: a systematic evaluation and meta-analysis
Authors: Hong Ziqiang , Sheng Yannan , Wang Jian , Mao Baohong , Wu Zhenzhen , Gou Yunjiu , Liu Qing 
Published: March 2023

Abstract
Objective: Systematic evaluation of the efficacy and safetyof robotic-assisted laparoscopic myomectomy (RALM)versus laparoscopic myomectomy (LM).
Methods: PubMed, Embase, The Cochrane Library and Web of Science database were searched by computer to seek relevant literatures in order to compare the efficacy and safety of RALM with that of LM from the establishment of the databases to January 2023, and Review Manager5.4 software was utilized to perform a meta-analysis of the literatures.
Results: A total of 15 retrospective clinical controlled studies were included. There exists a total of 45702 patients, among 11618 patients in the RALM group and the remaining 34084 patients in the LM group. Meta-analysis results revealed that RALM was associated with less intraoperative bleeding(MD=－32.03, 95%CI －57.24 to －6.83, P=0.01), lower incidence of blood transfusions(OR=0.86, 95%CI 0.77 to 0.97, P=0.01), shorter postoperative hospital stay(MD=－0.11, 95%CI －0.21 to －0.01, P=0.03), fewer transitions to open stomach(OR=0.82, 95%CI 0.73 to 0.92, P=0.0006) and lower incidence of post-operative complications(OR=0.58, 95%CI 0.40 to 0.86, P=0.006) than LM; whereas, LM is more advantageous in terms of operating time(MD=38.61, 95%CI 19.36 to 57.86, P<0.0001); no statistically significant difference between the two surgical approaches in terms of maximum myoma diameter(MD=0.26, 95%CI －0.17 to 0.70, P=0.24).
Conclusion In the aspects of intraoperative bleeding, lower incidence of blood transfusions, postoperative hospital stay, transit open stomach rate and post-operative complications, RALM has unique advantage than that of LM; while LM has advantages over RALM in terms of operating time.
Persistent steatosis retards fibrosis regression during anti-HBV treatment in patients with chronic HBV infection
Authors: Zhang Mengyang , Chen Shuyan , Wu Xiaoning , Zhou Jialing , Wang Tailing , Liu Hui , Zhao Xinyan , Wang Bingqiong , Zhao Xinyu , Kong Yuanyuan , Soon Gwyneth Shook Ting , Ou Xiaojuan , Jia Jidong , Chen Wei , Sun Yameng , You Hong 
Published: March 2023

Abstract
Background: Despite the increasing prevalence of steatosis in patients with chronic hepatitis B (CHB), whether the changes in steatosis impact fibrosis regression during antiviral therapy remain unclear. We aimed to identify the association between histological changes of steatosis and fibrosis in patients undergone antiviral treatment.
Methods: Patients with paired liver biopsies before and after 78 weeks of antiviral therapy were enrolled in this study. Liver fibrosis was assessed by the Ishak score combined with Beijing Classification P-I-R score. Steatosis was evaluated by the nonalcoholic fatty liver disease activity score. Collagen in each site was quantitated by second harmonic generation/two photon excitation fluorescence technology. Serum proteomic changes after treatment were characterized by mass-based spectrometry.
Results: A total of 239 CHB Patients were included, and divided into four groups according to the changes in steatosis: 162 (67.8%) had no steatosis throughout, 24 (10.0%) developed new-onset steatosis, 21 (8.8%) had initial steatosis which disappeared, and 32 (13.4%) had persistent steatosis. The persistent steatosis group showed the lowest rate of fibrosis regression (14/32, 43.8%). Persistent steatosis correlated with decreased fibrosis regression significantly after adjusting for age, sex, fibrosis stage and metabolic factors at baseline, as well as the viral response (adjusted OR = 0.380, 95%CI 0.145-0.996, P = 0.049). This decreased fibrosis regression was associated with accumulated collagen in the perisinusoidal area. Patients with persistent steatosis showed unique changes in glycolipid metabolism according to the serum proteomic atlas.
Conclusions: Persistent steatosis correlated with decreased fibrosis regression during antiviral therapy in patients with CHB.
Facial dysbiosis induced by photoprotectors. Is there evidence for such an assumption?
Authors: Arantes Angela Bonjorno , Rosa Rosimeire Takaki , Oliveira Nicoly Subtil , Bianchini Luiz Fernando , Rached Rodrigo Nunes , Johann Aline Cristina Batista Rodrigues , Weber Saulo Henrique , Murakami Fábio Seigi , Maluf Daniela Florencio , Rosa Edvaldo Antonio Ribeiro 
Published: March 2023

Abstract
Dysbiosis is characterized by a disruption of bacterial homeostasis and may be associated with various skin diseases. Acne is a multifactorial inflammatory disease with a robust microbial component and numerous correlations with dysbiosis states. Furthermore, various factors are recognized as triggers for skin dysbiosis, including the use of certain cosmetics. Based on these arguments, we hypothesized that the use of photoprotective formulations could trigger dysbiosis and the occurrence of acne manifestations. To verify this assumption, six volunteers between 19 and 23 years of age, meeting all the inclusion criteria, received two applications a day of a non-commercial sunscreen formulation developed with the sun filters ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene dispersed in a base gel, with an estimated protection factor of 28.8. The pure base gel was used as a control. The samples were applied to an area delimited by a standard template (15 cm2) in an amount corresponding to 30 mg (2 mg cm2) for ten days. At two points in time, pre- and post-sample applications, the facial skin surface was swabbed to collect extracted DNA and processed to verify divergent degrees of 16S RNA coding sequences. The data obtained allowed us to determine the abundance of different bacterial entities at the genus and species levels. The results showed that key species of the acne process, such as Cutibacterium acnes and Staphylococcus epidermidis, seem to tolerate the evaluated formulation well, not being significantly affected by the formulation, suggesting no interference of its use concerning dysbiosis induction.
Genetic Diversity, Population Structure and Selection Signatures in Enset (Ensete ventricosum, (Welw.) Cheesman), an Underutilized and Key Food Security Crop in Ethiopia
Authors: Haile Alye Tefera , Kovi Mallikarjuna Rao , Johnsen Sylvia Sagen , Tesfaye Bizuayehu , Hvoslef-Eide Trine , Rognli Odd Arne 
Published: March 2023

Abstract
Enset (Enseteventricosum (Welw.) Cheesman) is a multipurpose, drought-tolerant and a key food security crop, which is the staple food for peoples in the South and Southwestern parts of Ethiopia. Despite its importance, enset is an orphan crop as regards genetic research and breeding. In this study, we characterized genetic diversity, population structure and selection signatures in 226 cultivated and 10 wild enset accessions collected from diverse enset growing regions of Ethiopia using 3505 high-quality SNP markers obtained from ddRAD-sequences. The population structure and cluster analyses clearly distinguished between cultivated and wild enset. AMOVA revealed much higher levels of genetic variation within populations and regions (91.2 and 92.4%, respectively) than between populations and regions (8.8 and 7.6%, respectively). This shows that the region of origin and environmental heterogeneity have little influence on the genetic variation. However, the genetic differentiation between regions was moderate to large (FST = 0.06–0.17). The genetic structure of enset was mainly shaped by eco-geographic factors, mode of propagation and cultivation status. Six genes potentially involved in sexual reproduction and flowering signalling, which are key processes underlying domestication and adaptation, were under positive selection demonstrating that sexual reproduction plays an important role in shaping enset diversity. A lot of unexplored diversity is available for improving enset in Ethiopia, with patterns of diversity consistent with divergent selection on adaptive traits. This diversity also shows potential for introducing enset as a more food secure crop for the food insecure regions in the dry north of Ethiopia.
Generalized Anxiety Disorder Screening Using Gad-7 Among in-school Adolescents of Anambra State, Nigeria: a Comparative Study Between Urban and Rural Areas
Authors: Mbanuzuru Ahoma Victor , Uwakwe Richard , Anyaoku Chinekwu Sochukwu. , Ojimba Anastacia Okwudili , Mbanuzuru Mary Chinyere , Ezenyeaku Amara Chijioke , Obi Darlington Chukwudinma , Okafor Christiana Nkiru , Okonkwo Uchenna Prosper 
Published: March 2023

Abstract
Background
Previous studies have reported that general anxiety disorder manifestations differ in diverse settings.
Objective
To determine and compare the prevalence of anxiety disorders among in-school adolescents in urban and rural areas of Anambra State.
Methods
A total of 1187 in-school adolescents were recruited using a multi-stage sampling technique. The study instrument was an interviewer-administered pretested questionnaire adopted from General Anxiety Disorder (GAD-7). Data were analyzed with the IBM Statistical Package for the Social Sciences (SPSS) version 22.
Result
One hundred and twenty of the participants out of the 1187 (10.1%) were found to have generalized anxiety disorders using GAD-7 as screening tool. The prevalence of anxiety revealed that urban participants had a higher prevalence compared to their rural counterparts (11% vs 8.8%), while females had a higher prevalence compared to the males in the ratio of 3:2 (or 12% vs 8%). The prevalence of anxiety disorders among females was higher than that of males even when compared based on a rural and urban settings. When all other variables are held constant, urban participants were found to have a 50% higher chance of being identified with anxiety disorders compared to their rural participants (OR = 1.500, C.I.:1.002–2.246, p = 0.049).
Conclusion
Anxiety disorder was found in 10% of the participants. The females have a higher propensity to exhibit anxiety disorder than the males. Anxiety status affects how adolescents view their general health.
An AI Fuzzy Clustering based Routing Protocol for Vehicular Image Recognition in Vehicular Adhoc IoT Networks
Authors: Mavaluru Dinesh , Enduri Murali Krishna , Thiyagarajan Akila , Anamalamudi Satish , Sriniva Karthik , Carie Chettupally Anil 
Published: March 2023

Abstract
A vehicular ad-hoc IoT network (VA-IoT) plays a key role in exchanging the constrained networked vehicle information through IPv6 enabled sensor nodes. It is noteworthy to understand that vehicular IoT is interconnection of vehicular ad-hoc networks with the support of constrained IoT devices. Routing protocols in VAN-IoT is designed to route the vehicular traffic in the distributed environments. In addition, VAN-IoT is designed to enhance the road safety by reducing the number of road accidents through reliable data transmission. Routing in VAN-IoT has a unique dynamic topology, frequent spectrum, and node handover with restricted versatility. Hence, it is very crucial to design the hybrid reactive routing protocols to ensure the network throughput and data reliability of the VAN-IoT networks. This paper aims to propose an AI based Reactive Routing protocol to enhance the performance of the network throughput, minimize the end-to-end delay with respect to node mobility, spectrum mobility, link traffic load and end-to-end network traffic load while transmitting the vehicular images. In addition, the performance of the proposed routing protocol in terms of image transmission time is being compared with the existing initiative-taking and reactive based routing protocols in Vehicular Adhoc IoT (VA-IoT) Networks.
Uranium weapons being employed in Ukraine have significantly increased Uranium levels in the air in the UK
Authors: Busby Christopher 
Published: March 2023

Abstract
Data covering the period November 2017 to November 2022 was obtained from the Atomic Weapons Establishment, Aldermaston to find if there was an increase in Uranium associated with the Ukraine war. Results from 9 High Volume Air Samplers deployed onsite and offsite by AWE showed that there were significantly increased levels of Uranium in all 9 HVAS samplers beginning in February 2022 when the war began. The result has significant public health implications for the UK and Europe.
Multidiscipline design optimization for large-scale complex nonlinear dynamic system based on weak coupling interfaces
Authors: Du Wei , Piao Si-yang , Piao Ming-wei , Nie Chun-ge , Dang Peng , Li Qiu-ze , Tao Yi-nan 
Published: March 2023

Abstract
For hi-tech manufacturing industries, developing large-scale complex nonlinear dynamic system must be taken as one of basic works, formulating problems to be solved, steering system design to a more preferable direction, and making correct strategic decisions. By using effective tools of big data mining, Dynamic Design Methodology was proposed to establish technical platform of Multidiscipline Design Optimization such as High Speed Rolling Stock, including three key technologies: i) Analysis graph of full-vehicle stability properties and variation patterns, providing instructive guidance on optimal parameter configuration of self-adaptive improved design for higher speed bogies to reduce track force; ii) Improved transaction strategy of flexible body to MBS interface, making boundary loading treatments more subtle to implement weak coupling interface of aluminium alloy car body to equipment cabin under floor frame; iii) Seamless collaboration with weldline fatigue damage assessments, ensuring structure integrity via correct Modal Stress Recovery. Steel rail profession unilaterally initiated improved design of wheel-rail relationship, which is proved to be unfavourable to commercial applications for Chinese High Speed Rails. On first fluttering phenomenon of service car body, contrastive analyses of line tracking tests and rigid-flex coupling simulations show that internal lateral coupling resonance of such as traction converter has been one of main restrictive factors that determine cost effectiveness. Whilst self-adaptive improved solution is one of more favourable options. Comprehensive evaluations show that only under rational conditions of wheel-rail matching, i.e. 0.10 ≥ λeN > λemin and λemin= (0.03–0.06), can this low cast solution achieve three goals of low track conicity, optimal route planning and investment benefit maximization.
Fate of herbicide residues in soil- Australian context: insights towards mechanism, aspects, and recent advancements
Authors: Chowdhury Imtiaz , Doran Gregory S. , Stodart Benjamin J. , Chen Chengrong , Wu Hanwen 
Published: March 2023

Abstract
Herbicides are chemical compounds that are toxic to weed plants. Modern agriculture relies heavily on herbicides for the control of weeds to maximize yield in crops. It is estimated that herbicide usage in the Australian grains industry increased by more than 30% from 2002 to 2018, approximately $1.80 billion. The increased popularity of herbicides in farming systems has not only raised concerns about their negative impacts on the environment, human health, and agricultural sustainability due to the rapid evolution of herbicide resistance, but also raised questions about their fate in soil. Due to excessive use of herbicides, there is great concern about contamination which can lead to soil and water pollution, reduced biodiversity, and depression in soil heterotrophic bacteria (including denitrifying bacteria) and fungi. Moreover, understanding the fate of herbicides in soil is a prerequisite for the precise assessment of its behaviour and potential environmental risk. This review illustrates a brief overview of the present status of herbicide residues in Australian farming systems with a detailed understanding of the transport and degradation processes of herbicides in soil. Furthermore, this review also encompasses microbial degradation, mechanisms, factors, and microorganisms associated with degradation and recent advancement in microbial degradation of herbicides.
Stereo- and regioselective boryllithiation and -sodiation of alkynes: reductive approach using flow microreactors
Authors: Jiang Yiyuan , Kurogi Takashi , Yorimitsu Hideki 
Published: March 2023

Abstract
The stereo- and regioselective syn-boryllithiation and -sodiation of alkynes have been achieved by reductive borylmetallation using flow microreactors. This method involves the fast mixing of a solution of an alkyne and stoichiometric alkoxypinacolborane with an alkali metal arenide solution, which efficiently generates highly reactive β-borylalkenyllithium and -sodium species by suppressing undesired diboration that inevitably occurs in a batch reactor. Unlike the conventional three-component borofunctionalization, the intermediates can be generated in the absence of electrophiles, which has enabled diverse electrophiles to participate in various syn-borofunctionalizations such as borylsilylation, borylhalogenation, borylcarbonylation, borylsulfenylation and borylarylation. Trapping with aldehydes and ketones provides a series of oxaboroles of biological interest. Furthermore, unsymmetrical diarylacetylenes undergo highly regioselective borylmetallation, which is applicable to the stereo- and regiocontrolled syntheses of multisubstituted oxaboroles and differently tetrasubstituted alkenes.