bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical Cancer: A Review of Epidemiology, Treatments and Anticancer
Drugs
Authors: Mohammadian Taher , Esmaeili Davoud , Babakanrad Elmira , Behzadi Payam 
Published: February 2023

Background:
Cancer is the second leading cause of death among men and women and a
highly prevalent cause of mortality among women. Having sexual relations at a young age, having
multiple sex partners, multiple pregnancies, long-term use of birth control pills, receiving a kidney
transplant, and sexually transmitted diseases (STDs) are the major risk factors of cervical cancer.
Although the risk of cervical cancer has recently increased, its mortality rate has declined. This study
aimed to review cervical cancer, its epidemiology, etiology, treatment methods, and various chemical
plant- and microorganism-derived drugs.

Material and Methods:
Complete information collection was performed by reading most of the
available articles.

Results:
Human papillomavirus (HPV) infection is the main cause of cervical cancer, and the best
way to prevent it is vaccination between the ages of 9 and 11 years, screening women and, more importantly,
educating girls. One of the easiest methods to screen for this disease is Pap tests and HPV
genotyping (high-risk strains 16 and 18). Cervical cancer is asymptomatic in the early stages, but
after spreading to other parts of the body, it causes symptoms, such as bleeding, pelvic pain, and
dyspareunia. Cervical cancer treatment is based on the stage of the disease and the involvement of
other parts of the body. In general, however, surgery, chemotherapy, radiotherapy, and hysterectomy
are among the common treatments for cervical cancer. Each of these methods has its side effects; for
instance, chemotherapy destroys healthy as well as cancer cells.

Conclusion:
Nowadays, with molecular knowledge, new drugs have been developed that are free
from the side effects of cancer treatment methods and only affect cancer cells. All the results have
been reviewed and compiled.
Cardio-Metabolic Health and HRT in Menopause: Novel Insights in
Mitochondrial Biogenesis and RAAS
Authors: Renke Guilherme , Kemen Elaine , Scalabrin Priscila , Braz Cleibe , Baesso Thomaz , Pereira Marcela Batista 
Published: February 2023

Abstract:
Recent evidence shows the cardiometabolic effects of estrogen administration in postmenopausal women. Women have a cardiometabolic advantage during their reproductive years,
which is lost at menopause due to declining estradiol (E2). E2, also known as 17-beta-estradiol, has
diverse effects in its target tissues, including the cardiovascular (CV) system, through genomic and
non-genomic signaling. Metabolic changes characteristic of menopause include a worsening lipid
profile, changes in body fat distribution, epicardial and pericardial fat deposition, increased susceptibility to weight gain, and increased blood pressure, resulting in an increased risk of accelerated
cardiovascular disease (CVD) development. E2 mediates its cardioprotective actions by increasing
mitochondrial biogenesis, angiogenesis, and vasodilation, decreasing reactive oxygen species
(ROS) and oxidative stress, and modulating the renin-angiotensin-aldosterone system (RAAS). In
this review, we assess whether it is prudent to develop an approach to managing postmenopausal
women based on modifying the patient's CV risk that includes human-identical hormone replacement therapy (HRT), modulation of RAAS, and stimulating mitochondrial biogenesis. Further research is needed to assess the safety and benefit of HRT to reduce cardiometabolic risk.
Chondrosarcoma Skull Base: A Case Report
Authors: Bharti Jyotsna Naresh , Elhence Poonam , Bhaskar Suryanarayanan , Garg Pawan Kumar 
Published: February 2023

Introduction:
Chondrosarcomas are primary malignant bone tumor that rarely occurs in the
head and neck region. Squash cytology of skull base neoplasm shows atypical chondrocytes and myxoid
stroma, which suggests many possibilities like chordoma, chordoid glioma, chordoid meningioma
and chondrosarcoma. Isocitrate dehydrogenase gene (IDH) mutations have been reported in 50% to
60% of the head and neck region chondrosarcoma.

Case Presentation:
A 37-year-old female came to the outpatient department and complaint of difficulty
in walking and swaying to the right side for one year. The radiology was suggestive of right-sided
trigeminal schwannoma. However, the squash cytology showed the presence of necrosis, and pink to
bluish-coloured myxoid stroma. The tumor cells were pleomorphic and had a hyperchromatic nucleus,
hyalinized condensed to granular cytoplasm. The histopathological examination of intraoperative soft
tissue showed the presence of cellular lobules of atypical chondrocytes arranged in the myxoid background.
The features were of Chondrosarcoma. No parenchymal invasion was found.

Conclusions:
This case report aims to create awareness about a rare tumor, which rarely forms a differential
diagnosis for skull base neoplasms. As chondrosarcoma are immunoreactive to IDH1 so this
marker can be useful in clinching the diagnosis in conjunction with other immunohistochemical markers
in a small biopsy from skull base neoplasms.
The Beneficial Effects of Mesenchymal Stem Cells in Acute Kidney Injury:
A Narrative Review
Authors: Liu Yuxiang , Han Jibin , Fang Jingai , Li Rongshan 
Published: February 2023

Background:
Acute kidney injury (AKI) is a multifaced disease characterized by a rapid decline
in renal function. However, with growing insight into the pathophysiologic mechanisms of AKI,
currently available interventions for AKI are merely supportive. Thus, novel therapies are urgently needed
to improve the outcomes of patients with AKI. This narrative review aims to explore enhancing the
beneficial effects of Mesenchymal Stem Cells(MSCs) in AKI.

Methods:
The authors examined all studies regarding the role of MSCs in AKI. And the authors undertook
a structured search of bibliographic databases for peer-reviewed research literature using a focused
review question. The most relevant and up-to-date research was included.

Results and Discussion:
Based on encouraging preclinical results, stem cell therapy has been widely
explored over the last decade. Among the various stem cell types investigated, mesenchymal stem cells
are being intensely investigated by virtue of their numerous strengths, such as easy derivation, undemanding
cell culture conditions, anti-apoptosis, immunomodulation, and anti-inflammation effects. Mounting
evidence suggests that MSCs hold great potential in accelerating kidney repair following AKI in various
preclinical models. Unfortunately, low engrafting efficiency and poor survival rate of injected MSCs in
the injured renal tissue are major obstacles MSCs clinical application faces.

Conclusion:
Various strategies, including genetic manipulation, mimicking the cellular microenvironment
with different culture conditions, optimizing MSCs preparation and administration schedule, and
screening patients who may more like benefit from MSCs therapy, have been developed to enhance the
therapeutic potential of MSCs in AKI.
Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the
Function of Islet β Cells
Authors: Lin Xiuhong , Cheng Lin , Wan Yan , Yan Yuerong , Zhang Zhuo , Li Xiaohui , Wu Jiayun , Wang Xiaoyi , Xu Mingtong 
Published: February 2023

Background:
The RAS system is involved in the regulation of islet function, but its regulation remains unclear.

Objective:
This study investigates the role of an islet-specific miR-375 in the effect of RAS system on islet β-cells.

Methods:
miR-375 mimics and inhibitors were transfected into insulin-secreting MIN6 cells in the presence or absence of RAS component.

Results:
Compared to control, in Ang II-treated MIN6 cells, miR-375 mimic transfection results in a
decrement in cell viability and Akt-Ser levels (0.739±0.05 vs. 0.883±0.06 and 0.40±0.04 vs. 0.79±0.04,
respectively), while the opposite occurred in miR-375 inhibitor-transfected cells (1.032±0.11 vs.
0.883±0.06 and 0.98±0.05 vs. 0.79±0.04, respectively, P<0.05). Mechanistically, transfection of miR-
375 mimics into Ang II-treated MIN6 cells significantly reduced the expression of Mapkap1 protein
(0.97±0.15 vs. 0.63±0.06, P<0.05); while miR-375 inhibitor-transfected cells elevated Mapkap1 expression
level (0.35±0.11 vs. 0.90±0.05, P<0.05), without changes in mRNA expression. Transfection of
miR-375 specific inhibitors TSB-Mapkap1 could elevate Mapkap1 (1.62±0.02 vs. 0.68±0.01, P<0.05),
while inhibition of Mapkap1 could significantly reduce the level of Akt-Ser473 phosphorylation
(0.60±0.14 vs. 1.80±0.27, P<0.05).

Conclusion:
The effects of Ang II on mouse islet β cells were mediated by miR-375 through miR-375/Mapkap 1 axis. This targeted regulation may occur by affecting Akt phosphorylation of β cells. These results may provide new ideas and a scientific basis for further development of miRNA-targeted islet protection measures.
Study on the Mechanism of Hydrolyzed Seawater Pearl Tablet in Treating
Chronic Sleep Deprivation Mice Model
Authors: Lin Jiang , Luo Fei , Han Siyin , Xia Meng , Chen Zhenxing , Liu Peng 
Published: February 2023

Background:
Modern lifestyle increasingly deprives people from sleep to different degrees. Long-term sleep deprivation will facilitate body’s pathological behaviors, such as lethargy, depression, and anorexia.

Objective:
This study is an investigation into the mechanism of hydrolyzed seawater pearl tablet in treating chronic sleep deprivation mice model.

Methods:
The chronic sleep deprivation model was established involving C57BL/6mice; the body weight, behavioral characteristics, hippocampal structure, oxidative stress, apoptosis-related protein expression, and intestinal bacteria in mice were assessed to characterise hydrolyzed seawater pearl tablet.

Results:
Hydrolyzed seawater pearl tablet significantly accelerated body weight, open field test score,
and sugar water preference rate (P < 0.05), alleviated the structural damage of hippocampus, reduced
the content of MDA (P < 0.05), Bax protein expression, increased the content of GSH (P < 0.05), the
activities of SOD, GSH-Px, and Bcl-2 protein expression in the hippocampus, increased the Escherichia
coli, Bacteroides, Bifidobacterium and Lactobacillus (P < 0.05), which are beneficial bacteria
in the intestine, in chronic sleep deprivation mice, and reduced the amount of Clostridium perfringens
(P < 0.05), which are harmful bacteria in the intestine.

Conclusion:
Hydrolyzed seawater pearl tablet can improve the depression-like mental state of mice
caused by chronic sleep deprivation. The mechanism involves improving the antioxidant activity of
the hippocampus to eliminate the excessive ROS, which inhibits cell apoptosis and alleviates tissue
structure damage. Meanwhile, it may also be involved in adjusting the microbiota level and improving
the mental and behavioral activities of chronic sleep deprivation mice through the intestine-brain axis.
The Impact of Digital Transformation on Inpatient Care: Mixed Methods Study
Authors: Koebe Philipp , Bohnet-Joschko Sabine 
Published: February 2023

Background
In the context of the digital transformation of all areas of society, health care providers are also under pressure to change. New technologies and a change in patients’ self-perception and health awareness require rethinking the provision of health care services. New technologies and the extensive use of data can change provision processes, optimize them, or replace them with new services. The inpatient sector, which accounts for a particularly large share of health care spending, plays a major role in this regard.

Objective
This study examined the influences of current trends in digitization on inpatient service delivery.

Methods
We conducted a scoping review. This was applied to identify the international trends in digital transformation as they relate to hospitals. Future trends were considered from different perspectives. Using the defined inclusion criteria, international peer-reviewed articles published between 2016 and 2021 were selected. The extracted core trends were then contextualized for the German hospital sector with 12 experts.

Results
We included 44 articles in the literature analysis. From these, 8 core trends could be deduced. A heuristic impact model of the trends was derived from the data obtained and the experts’ assessments. This model provides a development corridor for the interaction of the trends with regard to technological intensity and supply quality. Trend accelerators and barriers were identified.

Conclusions
The impact analysis showed the dependencies of a successful digital transformation in the hospital sector. Although data interoperability is of particular importance for technological intensity, the changed self-image of patients was shown to be decisive with regard to the quality of care. We show that hospitals must find their role in new digitally driven ecosystems, adapt their business models to customer expectations, and use up-to-date information and communications technologies.
The Development of a UK Culturally Adapted and Modified Version of the Person Attuned Musical Interactions Manual: Protocol for a 2-Phase Mixed Methods Study
Authors: Waters Bryony , Orrell Martin , McDermott Orii 
Published: February 2023

Background
Previous research has suggested that care home interactions need significant improvements, especially those between staff and residents with dementia. Reasons for the lack of interactions are staff time pressures and residents’ language impairments. Although residents may experience reduced language abilities, they can continue to communicate through other forms, including nonverbal communication and music. Person Attuned Musical Interactions (PAMI) is a staff training tool that provides staff with music therapy skill-sharing to promote high-quality interactions between staff and residents using nonverbal communication and music. The tool was originally developed in Denmark. To ensure that the tool is appropriate for UK care homes, a team of researchers in the United Kingdom have modified and culturally adapted the tool.

Objective
This study aims to investigate the appropriateness of the adapted and modified manual for UK care homes and to explore the impact of PAMI on residents with dementia and care staff.

Methods
The project consists of 2 phases, a qualitative field-testing study and a mixed methods evaluation study, which have been developed following the Medical Research Council’s guidelines for complex interventions. Care staff and residents with dementia will be recruited from care homes in Lincolnshire, where the care staff will be trained in the PAMI intervention before implementing the intervention in their daily routines. Fortnightly reflective sessions will be provided throughout the phases to provide supervision and monitoring. The qualitative methods include interviews, reflective session transcripts, diary entries, and resident experience questionnaires. The quantitative outcome measures are residents’ music engagement, staff’s dementia competence, residents’ quality of life, and staff burden. The resident’s music engagement will be administered at 9 fortnightly time points. Staff’s dementia competence, resident’s quality of life, and staff burden will be administered at preintervention and postintervention time points.

Results
The study has been funded by The Music Therapy Charity as part of a PhD studentship. The study began recruiting in September 2021. The research team aims to publish the results of the first phase in July to September 2023 and those of the second phase in October to December 2023.

Conclusions
This study will be the first to investigate the modified version of PAMI. Therefore, it will provide feedback on the appropriateness of the manual for UK care homes. The PAMI intervention has the potential to offer high-quality music intervention training to a larger population of care homes who may currently be restricted by finances, the availability of time, and a lack of training opportunities.

International Registered Report Identifier (IRRID)
DERR1-10.2196/43408
Discusión de los roles de las actividades de la empresa, los consumidores y los grupos de interés en el cambio del valor de las marcas
Authors: Reynoso Espinoza Deivit Wilfredo , Arbaiza Fermini Lydia 
Published: February 2023

Este ensayo discute sobre algunos de los grupos y roles que se deben considerar en el análisis de los cambios en el valor de las marcas. Se plantean los roles activos y pasivos que tienen: las actividades de la empresa, los grupos de interés de la empresa y los consumidores. Las actividades de las empresas se vinculan con el valor de las marcas directamente a través de sus productos, pero especialmente por la experiencia, identidad y la moral de sus procesos. Los grupos de interés agregan la perspectiva que genera la imagen ética de la empresa en el valor de las marcas, como lo son las responsabilidades medioambientales, su integridad y la creación de valor compartido. Los consumidores son los principales agentes modificadores del valor de la marca. Estos no solo ligan el valor del producto adquirido con la satisfacción de la necesidad, sino agregan constructos sociales que identifican, distinguen y pueden clasificar a las empresas modificando su valor, gracias a la difusión de boca a boca físico y virtual (redes sociales). Este ensayo cobra especial importancia porque en los últimos años sean incrementado las empresas cuyas marcas superan en valor a las de sus activos tradicionales, y se necesita de análisis adicionales para entender este fenómeno.
The Type 1 Diabetes and EXercise Initiative (T1DEXI): Examining the acute glycemic effects of different types of structured exercise sessions in type 1 diabetes in a real-world setting
Authors: Riddell Michael C. , Li Zoey , Gal Robin L. , Calhoun Peter , Jacobs Peter G. , Clements Mark A. , Martin Corby K. , III Francis J. Doyle, , Patton Susana R. , Castle Jessica R. , Gillingham Melanie B. , Beck Roy W. , Rickels Michael R. 
Published: February 2023

<p> </p>
<p><strong>Objective:</strong> Maintenance of glycemic control during and following exercise remains a major challenge for individuals with type 1 diabetes. Glycemic responses to exercise may differ by exercise type (aerobic, interval, resistance), and the effect of activity type on glycemic control following exercise remains unclear.</p>
<p><strong>Research Design-Methods: </strong>The Type 1 Diabetes Exercise Initiative (T1Dexi) was a real-world study of at-home exercise. Adult participants were randomly assigned to complete six structured aerobic, interval, or resistance exercise sessions over 4-weeks. Participants self-reported study and non-study exercise, food intake, and insulin dosing (multiple-daily injection [MDI] users) using a custom smart phone application, and provided pump data (pump users), heart rate, and continuous glucose monitoring (CGM) data.</p>
<p><strong>Results: </strong>497 adults with type 1 diabetes, mean±SD age 37±14 years, HbA1c 6.6±0.8% (49±8.7 mmol/mol) assigned to structured aerobic (N=162), interval (N=165), or resistance (N=170) exercise were analyzed. Mean change in glucose during assigned exercise was -18±39, -14±32, and -9±36 mg/dL for aerobic, interval, and resistance, respectively (P<0.001), with similar results for closed loop, standard pump, and MDI users. Time-in-range 70-180 mg/dL [3.9-10.0 mmol/L] was higher during the 24-hours following study exercise when compared to days without exercise (76±20% vs. 70±23%; P<0.001).</p>
<p><strong>Conclusion: </strong>Adults with type 1 diabetes experienced the largest drop in glucose level with aerobic followed by interval and resistance exercise, regardless of insulin delivery modality. Even in well controlled adults with type 1 diabetes, days with structured exercise sessions contributed to clinically meaningful improvement in glucose time-in-range but may have slightly increased time below range.</p>
Pengaruh Kemampuan Literasi Digital Peserta Didik dan Kreativitas Guru Terhadap Prestasi Belajar Matematika Peserta Didik kelas VIII
Authors: Nadila Diah , Nursalam  , Angriani Andi Dian 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui adanya pengaruh kemamapuan literasi digital peserta didik dan kreativitas guru terhadap prestasi belajar matematika kelas VIII Madrasah Tsanawiyah Negeri Gowa. Pendekatan penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian ex-post-facto. Populasi dalam penelitian ini adalah peserta didik kelas VIII MTsN Gowa yang berjumlah 200 peserta didik dan sampel sebanyak 67 peserta didik. Beradasarkan hasil pengujian hipotesis dengan taraf signifikansi 5% diperoleh hasil yang menunjukkan bahwa (1) Kemampuan literasi digital peserta didik berpengaruh positif terhadap prestasi belajar matematika peserta didik kelas VIII MTsN Gowa sebesar 12,6%, (2) Kreativitas guru berpengaruh positif terhadap prestasi belajar matematika peserta didik kelas VIII MTsN Gowa sebesar 10,5%, (3) Kemampuan literasi digital peserta didik dan kreativitas guru berpengaruh positif terhadap prestasi belajar matematika peserta didik kelas VIII MTsN Gowa sebesar 17,7%. Dengan demikian, jika kemampuan literasi digital peserta didik dan kreativitas guru meningkat, maka prestasi belajar matematika peserta didik kelas VIII Madrasah Tsanawiyah Negeri Gowa juga akan meningkat.
EFEKTIVITAS IMAJINASI TERBIMBING (GUIDED IMAGERY) TERHADAP PENURUNAN NYERI PASIEN POST OPERASI : A LITERATUR REVIEW
Authors: Darmadi M. Nur Faizal , Hafid Muh Anwar , Patima Patima , Risnah Risnah 
Published: February 2023

ABSTRAKPembedahan dapat menyebabkan ketidaknyamanan bagi pasien karena tindakan pembedahan dapat menyebabkan trauma pada jaringan yang dapat menimbulkan nyeri. Penatalaksanaan nyeri dapat dilakukan dengan teknik non farmakologi salah satunya dengan terapi guided imagery.Penelitian ini bertujuan untuk mengetahui mengetahui efektivitas imajinasi terbimbing terhadap penurunan nyeri pada pasien post operasi . Metode yang digunakan digunakan dalam ‘Literatur review diawali dengan pemilihan topik, kemudian ditentukan keyword untuk pencarian jurnal menggunakan bahasa Indonesia dan Bahasa Inggris melalui beberapa database antara lain Pubmed, Springer link, dan Google Scholar. Kriteria inklusi dalam penelitian ini adalah artikel tahun 2010 sampai 2020, Fulltext artikel yang sesuai dengan topik literature dan fokus pada artikel yang menggunakan skala nyeri sebagai alat ukur.Hasil review artikel membuktikan bahwa terdapat efektivitas terapi imajinasi terbimbing penurunan skala nyeri pada pasien post operasi. Lima dari artikel menemukan secara statistik bahwa terjadi penurunan rasa nyeri pada pasien setelah diberikan terapi imajinasi terbimbing. Terapi imajinasi terbimbing juga dapat memberi kepuasan, kenyamanan, dan menurunkan kecemasan pada pasien post operasi. Terapi imajinasi terbimbing sebagai penatalaksanaan non- farmakologi dapat menurunkan nyeri post operasi. Terapi ini tidak menimbulkan efek samping, tidak memerlukan biaya, dan merupakan kegiatan non invasive yang mendukung model keperawatan holistik. Hasil Penelitian ini dapat dijadikan rujukan untuk penelitian berikutnya.