bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum asprosin and trimethylamine oxide levels in polycystic over syndrome with and without metformin treatment
Authors: KARAKULAK Koray , ÖNALAN Erhan , YAKAR Burkay , DÖNDER Emir , KİLİNC Faruk , GÜRSU Mehmet Ferit 
Published: September 2023

Purpose: The presence of a potential relationship between metabolic diseases and hormones and the intestinal flora has recently gained attention. Levels of asprosin and trimethylamine oxide (TMAO) may be associated with polycystic over syndrome (PCOS), which is a metabolic disease. The present study aims to investigate the potential relationship of PCOS with serum asprosin and TMAO levels.
Materials and Methods: This cross-sectional study included 30 PCOS patients on metformin, 30 PCOS patients not receiving treatment, and 30 healthy controls. The demographic, glucose, insulin resistance, lipid, and hormone profiles of the participants were analyzed. Serum asprosin and TMAO levels were investigated with the ELISA method.
Results: Patients with PCOS had higher BMI, serum glucose, triglyceride, ALT, insulin levels, and HOMA-IR scores compared with controls. The serum testosterone level was 28.1 ng/dl in the control group, 33.3 ng/dl in the PCOS group receiving metformin and 48.0 ng/dl in the untreated PCOS group, and there was a statistically significant difference. Neither serum asprosin nor TMAO levels were significantly different when compared between the three groups.
Conclusion: Serum asprosin and TMAO levels of individuals with PCOS and healthy controls were not significantly different. The receipt of metformin treatment by PCOS patients did not have a significant relationship with serum asprosin and TMAO levels.
The impact of maltreatment on symptom severity in patients with attention deficit hyperactivity disorder
Authors: SUZER GAMLİ İpek , YOLGA TAHİROĞLU Ayşegül 
Published: September 2023

Purpose This study aimed to compare the impact of maltreatment on the subtype, comorbidity, sociodemographic characteristics, and psychometric characteristics of attention deficit hyperactivity disorder (ADHD).
Materials and Methods: The study participants included 150 treatment-naïve children with ADHD with (n=75) and without (n=75) a history of maltreatment by parents. A sociodemographic form, the Conners Parent Rating Scale (CPRS), the Conners Teacher Rating Scale (CTRS), the Family Assessment Device (FAD), and the Stroop Form were applied.
Results: Earlier referral, peer discord, and lower parental age were frequent in the maltreated group, while the maternal employment rates were significantly lower. ADHD-combined type and comorbid oppositional defiant disorder were significantly higher in the maltreated group. The CPRS and FAD scores were also significantly higher).
Conclusion: A higher incidence of destructive behavioral patterns may increase the risk of maltreatment. Families of children with hyperactivity and defiant characteristics may have difficulties in managing behavioral problems and may exhibit domestic violence, with the Multidisciplinary approaches, including parental education programs and social investigation, should be considered.
Analysis of telomere length in patients with COVID-19 and investigation into its relationship with clinical- demographic data
Authors: SAVRUN Atakan , DİRİCAN Ebubekir 
Published: September 2023

Purpose: Novel coronavirus disease 2019 (COVID-19) is an infectious disease unknown before the 2019 outbreak in Wuhan. This study evaluated telomere length in COVID-19 (+) and (-) samples with clinical-demographic parameters.
Materials and Methods: DNA was isolated from COVID-19 (+) (n=70) and (-) (n=70) patients. Telomere length was determined by real-time-PCR (RT-PCR). The 2–∆∆Ct method was used to analyze the telomere length of the samples.
Results: There were significant differences in creatinine, LDH, ferritin, WBC, NEU and CRP in COVID-19 (+) patients compared to COVID-19 (-) patients. The NEU/LYM (or N/L) ratio was found higher in the patients with COVID-19 (+), than in COVID-19 (-). On the other hand, our COVID-19 (+) patients (mean±std:0.93±0.58) had significantly shorter telomere lengths than the COVID-19 (-) (mean±std:1.26±0.76). Moreover, COVID-19 (+) male patients (mean±std:1.06±0.50) had longer telomere length than female patients (mean±std:0.76±0.54). Telomere length was significantly shorter in patients with COVID-19 (+)with high blood urea nitrogen (BUN), high creatinine, high hematocrit, high NEU levels, normal platelets (PLT), and low WBC levels.
Conclusions: Our findings suggest that telomere length and blood parameter levels influence the severity of COVID-19. Blood parameters differed in patients with COVID-19 (+) and COVID-19 (-). As a result, increasing the number of similar studies in the future can demonstrate the significance of our findings.
Keywords: COVID-19, Telomere length, RT-PCR, NEU/LYM, blood
Evaluation of the effects of body and auricular acupuncture combination therapy in obesity control: a retrospective study
Authors: YILDIRIM Duygu İlke 
Published: September 2023

Purpose: The aim of this study is to retrospectively evaluate the effects of body (abdominal) and auricular acupuncture combination therapy on anthropometric measurements and blood parameters in obesity control.
Materials and Methods: This study is a descriptive, cross-sectional and retrospective study. This study was carried out by retrospectively scanning the patient files of the patients who applied to the obesity center between 01.05.2019 and 15.02.2020 and wanted to have acupuncture.
Results: There are 10 points selected: Shenmen (HT7, spirit gate), point zero, small intestine, large intestine, stomach, esophagus, mouth, appetite control (hunger), antidepressant and spleen point. The abdominal acupuncture points applied to the patients for the treatment of obesity are shown in this study. There are 6 points selected: ST 25, ST 26, REN 12 (CV12), REN 10 (CV10), REN 6 (CV6), REN 4 (CV4). The results show that combined ear and abdominal acupuncture resulted in significant weight loss in all participants in the acupuncture group. The mean high-density lipoprotein cholesterol (HDL-C) mean scores of the patients who underwent acupuncture were significantly higher whereas the mean low-density lipoprotein cholesterol (LDL-C) scores was significantly lower than the patients who did not receive acupuncture.
Conclusion: Ear and abdominal acupuncture applications applied for three months for weight loss in obese individuals provided significant weight loss, along with a significant decrease in waist/hip ratio and improvement in all other blood parameters.
Histone deacetylase inhibitory and antioxidant activities of some ethanolic plant extracts: A novel therapeutic approach for cancer
Authors: DAĞSUYU Eda , YANARDAĞ Refiye 
Published: September 2023

Purpose: The aim of this study was to evaluate histone deacetylase inhibitory and antioxidant activities of some ethanolic plant extracts.
Materials and Methods: In this study, the inhibitory effects of ethyl alcohol extracts prepared from various plants and some chemical compounds on histone deacetylase activity were investigated. In addition, the antioxidant activity of plant-derived active substances, which have had an important value in alternative medicine in recent years, has been determined to replace chemicals.
Results: All the plant extracts and chemical substances used in the study showed histone deacetylase inhibitory effect (with IC50 range of 0.000078-319.0 µg/mL) and antioxidant activity. The results indicated that the percentage of histone deacetylase inhibition and antioxidant activities increased with increasing concentrations of the plant extracts and chemical compounds.
Conclusion: These plant extracts which are potential sources of histone deacetylase inhibitors may be appropriately used as an alternative support to drug treatment rather than the use of toxic chemicals.
Effects of rosmarinic acid on cyclophosphamide-induced nephrotoxicity in rats
Authors: ÇETİNAVCI Dilan , YENİLMEZ Engin , BIYIK Ayşe Firuze , ALVER Ahmet , SAĞLAM Neslihan 
Published: September 2023

Purpose: Cyclophosphamide (CP) is an antineoplastic agent. It is used in the treatment of many types of cancer. Rosmarinic acid (RA) exhibits remarkable biological activities such as anti-inflammatory, antitumor, antibacterial, and antimicrobial effects. This study aimed to evaluate the effect of rosmarinic acid against CP-induced nephrotoxicity.
Materials and Methods: Eighteen male Sprague Dawley rats were randomly divided into 3 equal groups; Sham group (n=6): 0.9% saline solution/8 days/oral gavage + 0.9% saline solution/8th day/intraperitoneal, CP group (n=6): 0.9% saline solution/8 days/oral gavage + 200 mg/kg/8th day/intraperitoneal CP, and CP+RA group (n=6): 100 mg/kg/8 days/oral gavage RA + 200 mg/kg/8th day/intraperitoneal CP was applied. Hematoxylin and Eosin, Periodic Acid-Schiff, and Masson’s Trichrome staining were performed on the collected tissues
Results: Histopathological evaluation revealed tubular atrophy, glomerular damage, vascular congestion, vacuolization, and interstitial inflammation in the CP group. Histopathological scores were significantly lower in the CP+RA group compared to the CP group. Intertubular fibrosis was observed in the CP group compared to the Sham group. Fibrosis decreased with rosmarinic acid. PAS-stained sections from the CP group showed tubular epithelial vacuolization, brush border, and basal membrane disruption. These findings decreased with rosmarinic acid. The increased blood urea nitrogen level in the CP group was lower in the CP+RA group, while the decreased SOD level in the CP group was higher in the CP+RA group.
Conclusion: RA has protective effects against CP causing tubular atrophy, glomerular damage, vascular congestion, vacuolization, and interstitial inflammation in the kidney
The effect of hand morphometric measurements on the manual dexterity in students of Vocational School of Health Services
Authors: ÖZANDAÇ POLAT Sema , IŞIK Emir İbrahim , TUTUŞ Ezcan , GÖKER Pınar 
Published: September 2023

Purpose: This paper aimed to evaluate the manual dexterity tests and hand morphometry, and to research whether the dexterity tests and hand lengths were affected by gender and body mass index (BMI) or not.
Materials and Methods: This study was carried out on 114 adult subjects aged between 18 and 25 years (37 males and 77 females). Demographic characteristics including gender, age, dominant hand, height, weight, and body mass index (BMI) of all subjects were recorded. Additionally, hand morphometric measurements and manual dexterity tests called as O’Connor Finger Dexterity Test and Purdue Pegboard Test were applied.
Results: Some values such as the hand length (right and left), palmar length (right and left), dominant and non-dominant hand finger, and O’Connor Finger Dexterity Test-Left side showed significant differences between genders. Additionally, O’Connor Finger Dexterity Test scores for both sides were lower in males than in females. Purdue Pegboard-Right, and Purdue Pegboard-Left, Purdue Pegboard-Both Hands, Purdue Pegboard total were higher in males, whereas Purdue Pegboard (Assembly) was higher in females than in males. However, Purdue Pegboard measurement scores did not show a significant difference between genders.
Conclusion: Hand morphometric measurements and manual dexterity tests showed some changes in terms of gender and BMI. Additionally, the data obtained can provide crucial information for therapists and clinicians about hand rehabilitation.
Assessment of dural invasion in complex cases operated on by collaborative efforts of neurosurgery and otolaryngology for pathologies associated with the frontal sinus
Authors: GEDİZ Tolga , GÜR Özer 
Published: September 2023

Purpose: The aim of this study was to evaluate the common interventions performed by neurosurgery and otolaryngology in dural invasion in frontal sinus related pathologies.
Materials and Methods: A comprehensive study involving 45 patients who underwent surgical interventions for frontal sinus-associated pathologies between January 2018 and July 2023 was conducted collaboratively by otorhinolaryngology and neurosurgery departments. Patient data, including demographics, pathology types, and surgical approaches, were collected from medical records, surgical reports, imaging studies, and videos. Interdisciplinary surgical teams executed tailored interventions with documented techniques.
Results: Among 45 patients, 31 were female (68.8%) with a mean age of 44. Posterior wall defects were detected in 13 (28.8%) patients, and intervention was necessary for only 8 of them. Among the 8 (17.7%) patients with identified dural invasion, pathological dural tissue was excised, and duraplasty was performed in 5 (11.1%) cases. There were no neurological complications observed in patients during the postoperative period.
Conclusion: Despite limitations, the findings contribute to evolving knowledge and highlight the need for prospective studies to optimize patient care strategies.
A Deep-Learning Phase Picker with Calibrated Bayesian-Derived Uncertainties for Earthquakes in the Yellowstone Volcanic Region
Authors: Armstrong Alysha D. , Claerhout Zachary , Baker Ben , Koper Keith D. 
Published: September 2023

ABSTRACT
Traditional seismic phase pickers perform poorly during periods of elevated seismicity due to inherent weakness when detecting overlapping earthquake waveforms. This weakness results in incomplete seismic catalogs, particularly deficient in earthquakes that are close in space and time. Supervised deep-learning (DL) pickers allow for improved detection performance and better handle the overlapping waveforms. Here, we present a DL phase-picking procedure specifically trained on Yellowstone seismicity and designed to fit within the University of Utah Seismograph Stations (UUSS) real-time system. We modify and combine existing DL models to label the seismic phases in continuous data and produce better phase arrival times. We use transfer learning to achieve consistency with UUSS analysts while maintaining robust models. To improve the performance during periods of enhanced seismicity, we develop a data augmentation strategy to synthesize waveforms with two nearly coincident P arrivals. We also incorporate a model uncertainty quantification method, Multiple Stochastic Weight Averaging-Gaussian (MultiSWAG), for arrival-time estimates and compare it to dropout—a more standard approach. We use an efficient, model-agnostic method of empirically calibrating the uncertainties to produce meaningful 90% credible intervals. The credible intervals are used downstream in association, location, and quality assessment. For an in-depth evaluation of our automated method, we apply it to continuous data recorded from 25 March to 3 April 2014, on 20 three-component stations and 14 vertical-component stations. This 10-day period contains an Mw 4.8 event, the largest earthquake in the Yellowstone region since 1980. A seismic analyst manually examined more than 1000 located events, including ∼855 previously unidentified, and concluded that only two were incorrect. Finally, we present an analyst-created, high-resolution arrival-time data set, including 651 new arrival times, for one hour of data from station WY.YNR for robust evaluation of missed detections before association. Our method identified 60% of the analyst P picks and 81% of the S picks.
Probabilistic Seismic Hazard Analysis for China Based on Bayesian Network
Authors: Liu Chang , Lu Da-Gang 
Published: September 2023

Abstract
Bayesian network (BN) has important applications in disaster risk analysis due to its unique causal structure and probabilistic characteristics. This research begins with a detailed introduction to probabilistic seismic hazard analysis (PSHA) for China, and the utilization of BN-based modeling for seismic hazard and risk assessment. Subsequently, a comprehensive theoretical exposition of PSHA for China based on BN is presented. This includes a clear explanation of the three-level subdivision of seismic sources and the employment of the elliptical ground-motion model (GMM) in China. Regarding BN modeling, the values, conditional probabilities, and the impact of subdivisions of the nodes are carefully discussed with the assistance of a specific example from China. The advantages of BN in terms of both holistic and probabilistic computation are then demonstrated through the disaggregation of seismic hazard and various sensitivity analyses. Finally, the article concludes by summarizing its content, highlighting the advantages of BN, and outlining future work.
Public Libraries Can Be Open Science Laboratories for Citizen Science Projects
Authors: Bridgeman Matthew 
Published: September 2023

A Review of:
Cigarini, A., Bonhoure, I., Vicens, J., & Perelló, J. (2021). Public libraries embrace citizen science: Strengths and challenges. Library & Information Science Research, 43(2), 101090. https://doi.org/10.1016/j.lisr.2021.101090Objective – The objective of this study was to evaluate the potential of libraries supporting citizen scientist (CS) projects.
Design – Mixed methods program evaluation study.
Setting – 24 public libraries in Barcelona, Spain.
Subjects – Public librarians and library users.
Methods – It is a mixed methods and mixed population study done in several phases. The first phase involved training 30 librarians how to conduct a citizen science project. They were given a pre and post survey about their perceptions of citizen science and comfort-level in conducting a project. The second phase involved a project run by the now-trained librarians with library user participation. At this phase a questionnaire was given to the users at the start and end of the project. Finally, a focus group of librarians was asked about their project. The responses were evaluated through thematic analysis. Seven libraries participated in the focus groups.
Main Results – During the first phase of the study, the survey found the librarians were pessimistic about user participation in a citizen science project, both at the beginning (75%) and at the end (79%) of the session. Though they felt confident in discussing citizen science (100%) and had high satisfaction in the training (70%), only 42% felt confident to conduct a project on their own. The second phase involved the users, 94% of whom had never participated in a CS project. At the end, 70% of users said the project positively changed their perceptions of the library and 70% were satisfied with the experiment. During the focus groups, librarians said the project brought new users into the library and had the potential to build more relationships among participants and with the community. Major challenges discussed were user commitment to the project and the workload required by librarians, however they all answered positively when asked about continuing with CS projects.
Conclusion – This study showed that citizen science projects can be successfully implemented in public libraries. Public libraries are facing challenges caused by societal change, the rise of open science, and more transparent and novel democratic ways of knowledge production. Updating public library infrastructure would be needed to support these projects more fully. This may involve building partnerships and developing new guidelines. There is potential for public libraries to be leaders and innovators in citizen science.
Digital modems of minimum frequency shift keying signals and their characteristics
Authors: Tyazhev Anatoly I. 
Published: September 2023

Background. The need to describe the features of the formation of minimum frequency shift keying signals, reveal the advantages of this type of modulation, provide circuits for digital demodulators of minimum frequency shift keying signals that provide the best reception noise immunity, and indicate ways to improve the spectral efficiency of minimum frequency shift keying signal modems. Aim. Various options for constructing digital modems for minimum frequency shift keying signals, features of modem circuits for even and odd numbers of half-periods on segments of the duration of transmitted messages, as well as the specifics of the formation of reference oscillations in coherent demodulators are considered. Methods. The principle of operation of modulators and demodulators of minimum frequency shift keying signals is explained by the timing diagrams of signals at various points in the paths for the formation and detection of minimum frequency shift keying signals. This representation ensures the reliability and clarity of the operation of modems of minimum frequency shift keying signals. Results. It is shown that coherent demodulators of minimum frequency shift keying signals provide the same noise immunity as opposite signals of relative phase shift keying, but at the same time they have a constant signal level and a smaller spectrum width. A dual-channel minimum frequency shift keying signal modem doubles the spectral efficiency of a single-channel modem, but the signal level becomes inconsistent. Conclusion. Information is given explaining the reason for the widespread use of minimum frequency shift keying signals in cellular communication systems, in space communication systems and in cordless phones, as well as ways to further improve digital modems of minimum frequency shift keying signals.
Unidades fraseológicas do universo paraense numa perspectiva geofraseológica
Authors: Dias Cecília Maria Tavares , Razky Abdelhak , Guedes Regis José da Cunha 
Published: September 2023

Este artigo insere-se no âmbito da Fraseologia, com o objetivo de analisar as unidades fraseológicas égua da facada, mas quando, levou o farelo e mas credo mapeadas em 15 localidades do estado do Pará. Para essa análise, baseamo-nos em pressupostos fraseológicos de Mejri (1999, 2012, 2017), Zuluaga (1980), Corpas Pastor (1996), Fulgêncio (2008), bem como nas perspectivas da Geossociolinguística de Razky (1998), Razky e Guedes (2015) e da Geofraseologia. Os dados foram coletados por meio de um questionário aplicado, via Google Forms, a 53 informantes de duas faixas etárias (18 a 40 anos e 50 a 80 anos), sendo 34 pessoas do sexo feminino e 19 do sexo masculino, naturais das 15 localidades paraenses selecionadas. De acordo com a análise das unidades polilexicais, os resultados alcançados demonstram que, sendo a fraseologia um fenômeno universal para todas as línguas vivas (MEJRI, 2012), as unidades estudadas possuem características morfossintáticas e semânticas, cuja estabilidade atribuída por Mejri (1997), assegura a estreita relação entre os elementos dos fraseologismos, que os leva a perder o significado primário para adquirir um novo sentido, desse modo, o uso das referidas expressões dão mostras da vitalidade de uma língua ativa nas localidades paraenses.