bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Contemporary Comparison of Laparoscopic versus Open Partial Nephrectomy for Renal Cell Carcinoma
Authors: Nicaise Edouard , Feldman Adam S. , Gusev Andrew , Yu Alice , Nimmagadda Naren , Wszolek Matthew F. , McGovern Francis , Blute Michael L. , Dahl Douglas M. 
Published: August 2023

Abstract
Purpose:
To analyze surgical and oncologic outcomes of patients undergoing open partial nephrectomy (OPN) versus laparoscopic partial nephrectomy (LPN) for treatment of renal cell carcinoma (RCC).
Methods:
We retrospectively investigated our institutional RCC database for patients who underwent PN for RCC from 1997-2018. Decision for technique was at the discretion of the operating urologist, following practice patterns and training history. Outcomes analyzed included pre/peri/post-operative parameters, pathologic outcomes, and disease recurrence rates.
Results:
1088 patients underwent PN from 1997-2018. After exclusionary criteria, 631 patients who underwent 647 unique PNs for a total of 162 OPN and 485 LPN remained. Baseline, pre-op, and pathologic characteristics were not different. Surgical time was lower in laparoscopic cases [185 vs 205 minutes] (p = 0.013). Margin involvement was not different; LPN had lower estimated blood loss (EBL) [150 vs 250 mL] (p < 0.001) and longer ischemia time [21 vs 19 min] (p = 0.005). LPN had shorter length of stay [2 vs 4 days] (p < 0.001), fewer overall complications (p < 0.001), and no difference in high-grade complications [2.89 vs 4.32%] (p = .379). Fewer LPN patients developed metastases [1.65 vs 4.94%] (p = 0.0499). Local recurrence rates were not different [1.24 vs 3.09%] (p = 0.193). Renal function was equivalent between cohorts post-operatively.
Conclusion:
Our results show that LPN has equivalent oncologic outcomes to OPN, with no difference in patient and tumor characteristics. LPN was associated with lower EBL, shorter length of stay, and lower overall complication risk. Renal function was equally maintained.
The Double-Edged Sword of αB-Crystallin Chaperone Activity: Insights from P39L Mutant at N-terminal region
Authors: Barati Anis , Somee Leila Rezaei , Shahsavani Mohammad Bagher , Ghasemi Atieh , Hoshino Masaru , Hong Jun , Moosavi-Movahedi Ali Akbar , Agnetti Giulio , Yousefi Reza 
Published: August 2023

Abstract
The substitution of leucine to proline at position 39 (P39L) in human αB-crystallin (αB-Cry) has been associated with conflicting interpretations of pathogenicity in cataracts and cardiomyopathy. This study aimed to investigate the effects of the P39L mutation on the structural and functional features of human αB-Cry. The mutant protein was expressed in Escherichia coli (E. coli) and purified using anion exchange chromatography. We employed a wide range of spectroscopic analyses, gel electrophoresis, transmission electron microscopy (TEM), and atomic force microscopy (AFM) techniques to investigate the structure, function, stability, and fibrillation propensity of the mutant protein. The P39L mutation caused significant changes in the secondary, tertiary, and quaternary structures of human αB-Cry and increased the thermal stability of the protein. The mutant αB-Cry exhibited an augmented chaperone activity and an altered oligomeric size distribution, along with an increased propensity to form amyloid aggregates. It is worth mentioning, increased chaperone activity has important positive and negative effects on damaged cells related to cataracts and cardiomyopathy, particularly by interfering in the process of apoptosis. Therefore, this study provides important insights into the effect of proline substitution by leucine at the N-terminal region on the dual nature of chaperone activity in human αB-Cry, which can act as a double-edged sword.
Experimental demonstration of scalable quantum key distribution over a thousand kilometers
Authors: Aliev Aziz , Statiev Vladlen , Zarubin Ilja , Kirsanov Nikita , Strizhak Danil , ﻿﻿﻿Bezruchenko Alexander , Osicheva Alexandra , Smirnov ﻿Alexandr , Yarovikov Michael , Kodukhov Alexey , Pastushenko Valeria , ﻿Pflitsch﻿ Markus , Vinokur Valerii 
Published: August 2023

Abstract
Secure long distance communications protecting the transmitting of sensitive information vital for business and advanced technologies from being accessed by unauthorized individuals, is one of the major challenges of modern life. The existing means of transmitted data protection are vulnerable to upcoming quantum computer attacks. Yet, remarkably, the quantum mechanics that engendered a threat to secure communications offers a guaranteed protection against the malicious attacks allowing to develop novel quantum key distribution (QKD). The major problem of the long-distance transmission arises due to essential signal decay in optical channels occurring at distances about a hundred kilometers. We resolve this problem by an original Terra Quantum QKD (TQ-QKD) protocol using semiclassical pulses containing enough photons for random bit encoding and exploiting erbium amplifiers to retranslate photon pulses and, at the same time, ensuring that at the chosen pulse intensity only a few photons can go outside the channel even at distances of about a hundred meters.As a result, an eavesdropper is incapable to utilize the lost part of the signal. A central component of the TQ-QKD protocol is the end-to-end loss control of the fiber-optic communication line. Our control precision reduces the degree of the signal leak below the detectable level, depriving an eavesdropper any possibility to efficiently utilize the lost part of the signal. Our work experimentally demonstrates the implementation of the TQ-QKD protocol allowing for a fully secure quantum key distribution over 1079 kilometers. Further refining of the transmitting scheme's components will expand the secure transmission scale over the global distances.
Effect of mowing on population maintenance of the endangered silver-studded blue butterfly, Plebejus subsolanus iburiensis (Lepidoptera: Lycaenidae), throughout its life cycle
Authors: Hayamizu Masato , Nakahama Naoyuki , Ohwaki Atsushi , Kinoshita Gohta , Uchida Yoko , Koyama Nobuyoshi , Kida Kazutaka 
Published: August 2023

Abstract
Introduction: The decline in semi-natural grasslands is posing a threat to several grassland insect species, including the silver-studded blue butterfly, Plebejus subsolanus ssp. iburiensis, which is nationally rare species of wild fauna in Japan.
Aims: This study aimed to investigate the impact of mowing on larval and adult populations of P. subsolanus in a conservation area and to identify suitable habitat management methods for this species and other butterflies. We surveyed the number of larvae and adults of P. subsolanus, other butterfly species, and the height, cover, and number of inflorescences of the host plant (Vicia unijuga), in both mowed and unmowed areas.
Results: Larvae only appeared in the mowed area, and the cover and height of host plant were markedly higher in the mowed area. Furthermore, the number of adult P. subsolanus was substantially higher in the mowed areas. However, no statistical differences were observed in the number of other butterfly species, species richness, inflorescences or number of flowering plants between the mowed and unmowed areas.
Discussion: The mowed area is an important habitat for both larvae and adults of P. subsolanus. Although there were no differences in the number of other butterfly species and flowering plants between the mowed and unmowed areas, the vegetation height was negatively correlated with these variables. Implications for insect conservation: Our results show that the creation of areas with reduced vegetation height could be effective in the conservation management of butterfly and floral communities, including P. subsolanus and its host plants.
Multi-faceted Analysis Reveals the Characteristics of Silk Fabrics on A Liao Dynasty DieXie Belt
Authors: Ge Ruochen , Cong Lili , Fu Yongping , Wang Bing , Shen Guiyun , Xu Bing , Hu Mingzhou , Yu Han , Zhou Jie , Yang Lu 
Published: August 2023

Abstract
The Liao dynasty's highly developed textile industry was characterized as "the best in the world" in ancient Chinese literature. This study analyzed two textiles on a 蹀躞(DieXie)belt excavated from the No.1 Liao dynasty noble tomb of Zhangjiayao Forest (Shenyang, China), with one wrapping around the leather belt (T1) and the other on the surface of a leather pouch hanging on the belt (X1). They were identified as silk based on structures by morphological observation and chemical components revealed by Fourier Transform Infrared spectroscopy (FTIR). Proteomics and enzyme-linked immunosorbent assay (ELISA) were used to investigate the animal origin of the silk, and the original color and dyestuffs of T1 were examined by liquid chromatography-mass spectrometer (LC-MS/MS). The results have shown that T1 consists of three layers of Bombyx mori silk plain fabric, and its original color was yellow-red dyed with madder and plants containing flavonoid dyeing tissue, consistent with the color of DieXie belts recorded in the ancient literature. The silk on the pouch is a layer of plain fabric, while the upper layer is embroidery on the Four-end-complex gauze, which was made of twisted Bombyx mori silk. We believe that the silk wrapping around the leather belt was to provide additional comfort and aesthetics after dyeing while protecting the leather, which is prone to warping and moisture. This study suggests that such silk fabrics with high specifications are one of the manifestations of the distinguished status of the tomb owner. The integration of various analytical methods on ancient silk fabrics enables us to learn various information about their textile forms, silk animal origins, colors and dyestuffs, revealing the highly developed silk waving techniques and prosperous costume culture of the Liao Dynasty.
Cellulose-based bi-layer hydrogel evaporator with a low evaporation enthalpy for efficient solar desalination
Authors: Shu Lian , Zhang Xiong-Fei , Wang Zhongguo , Liu Jun , Yao Jianfeng 
Published: August 2023

Abstract
Interfacial evaporation through hydrogel-based evaporators is emerging as a sustainable and cost-effective strategy for drinkable water production. Herein, a specially designed bi-layer hydrogel evaporator was fabricated and used for efficient solar water desalination. The cotton linter cellulose was dispersed in highly concentrated ZnCl2 (65%) solution, and then cross-linked by epichlorohydrin to prepare cellulose composite hydrogel. After removing inorganic salts by salt-leaching, polyaniline (PANi) with a broadband and wide-range light absorption was then integrated into the hydrogel through in situ polymerization to construct a bi-layer evaporator. Due to the interaction between water and cellulose/PANi, the water could be evaporated with a low-energy demand, and the heat from the sunlight could be confined at the interface to achieve an efficient water evaporation. Therefore, the hydrogel evaporator demonstrates an optimal evaporation rate of 3.07 kg m-2 h-1 and photothermal conversion efficiency of 94.42% under 1 sun (1 kW m-2) irradiation. This work provides new possibilities for efficient solar water purification systems with assured water quality.
Optimization on the earlier stages of development of a satellite’s solar array for reduced impact on attitude control during deployment
Authors: Mota Renan , Rocco Evandro 
Published: August 2023

Abstract

During the development of a highly complex system, mid-project modifications can generate additional costs. Those costs can get exponentially higher as the development advances into its final stages. With that in mind, optimizing the subsystems’ components, by choosing the appropriate ones at the beginning of the project can reduce both costs and risks of a space mission. This choice can be facilitated by the use of a computational model, based on a set of precise mathematical models, capable of creating a scenery equivalent to the mission’s. Simulations run with the model allow the analysis of a diverse range of parameters and events. However, it doesn’t eliminate the fact that many of these parameters can influence in the performance of others, and they commonly conflict with each other, making this a multiobjective problem. In this study, the Smallest Loss Criterion is used to aid in the decision making process of artificial satellite structural design. The scenery of this paper’s study is the design of a solar panel deployment system and the impact the choice of its structural parameters can have on the control system during the deployment operation. A pool of solutions is acquired through simulations and the Smallest Loss Criterion is applied with the objective of finding a single balanced solution that can minimize maximum deviation, settling time, and error while maximizing the panel’s absorption surface.
Spatial distribution of soil carbon inputs in permanent grassland vs. cropland in hedge agroforestry systems
Authors: Lesaint Lucas , Viaud Valérie 
Published: August 2023

Abstract

Hedge agroforestry systems are known for their potential to store large amounts of carbon (C) in agricultural soils, but there remains a lack of understanding about the spatial distribution of soil organic C (SOC) stocks near hedges. This study thus focused on the spatial organisation of C inputs near hedges in two crop-livestock systems in Normandy, France. The two sites selected consisted of a permanent grassland or a cropland succession (i.e. annual crops and temporary grassland), each with similar adjacent hedges. At both sites, C inputs from fine roots, hedge leaf litter, organic fertilisation, crop/grass residues and grazing were measured from 0–30 cm in depth at distances of 1, 3 and 10 m from the hedge. At the same time, SOC stocks and their distribution in the fine and coarse fractions of the soil were measured from 0–90 cm in depth at the same distances. Results showed that in the cropland there was higher C inputs from fine-root turnover and hedge leaf litter at 1 and 3 m from the hedge and from crop residues at 10 m from the hedge. In comparison, the grassland received more C inputs from fine-root turnover and grass residues at 1 and 3 m from the hedge. C input from hedge leaf litter was associated with high SOC storage in the coarse soil fraction, while C inputs from fine roots were associated with high SOC storage in the fine soil fraction.
Boys Do Cry: A randomised controlled trial testing the effects of a music video promoting help-seeking for mental health difficulties in Australian men
Authors: Nicholas Angela , Requena Simone Scotti , Rice Assoc Prof Simon , Spittal Matthew J , MacKinnon Andrew , Seidler Zac , Ftanou Maria , Fletcher Justine , Le Long Khanh-Dao , Mihalopoulos Cathrine , Pirkis Jane 
Published: August 2023

Abstract

Purpose In Australia and internationally, it is men who predominately die by suicide. Men are less likely than women to seek help for their mental health difficulties and this may contribute to their higher suicide rates. We created a 4-minute music video encouraging Australian men to seek help for mental health difficulties (Boys Do Cry). We aimed to assess in a randomised controlled trial (RCT) whether the Boys Do Cry video increased men’s intentions to seek help for mental health difficulties from baseline (T1) to post-intervention (1 week = T2).Method We conducted an online single-blind, two-arm RCT comparing the effects of Boys Do Cry against a control video. Analyses were undertaken on an intent-to-treat basis using linear mixed effects models with variables for trial arm, occasion of measurement and their interaction. Intervention effectiveness was assessed by comparing the mean difference between arms in change of the total score on the General Help-Seeking Questionnaire (GHSQ) from T1 to T2.Results 476 participants were randomised (intervention = 243; control = 233). At T1, GHSQ means were similar (intervention = 45.28; control = 45.70). After viewing the videos, GHSQ means increased in both arms (intervention = 47.33; control = 46.59), with no evidence of a difference in scores at T2 (modelled mean difference = 0.62, 95% CI -1.11 to 2.35, p = 0.485). Similar results were observed for all secondary outcomes. No adverse events were observed.Conclusions Boys Do Cry demonstrated some evidence of a positive effect on help-seeking intentions among Australian men; however, so too did the control video, and no significant difference was observed.Trial registration ANZCTR No. 2621001008819. Registered 30 July 2021.
Targeting the p97-Npl4 Interaction Inhibits Tumor-infiltrated Regulatory T but Promotes Th17 Cell Development to Selectively Trigger Antitumor Immunity
Authors: Zhou Zhaocai , Nie Pingping , Yu Ruixian , Cao Zhifa , Zhang Weihong , Meng Yang , Zhang Hui , An Liwei , Tong Zhenzhu , Jiang Xiaoya , Wang Shilong , Han Yi , Wang Wenjia , Li Bin , Xu Yuanzhi , Jiao Shi 
Published: August 2023

Abstract

Therapeutic targeting of tumor-infiltrated regulatory T (TI-Treg) cells is attracting for cancer treatment; yet current ways remain lacking of selectivity and efficiency. Due to its crucial role in protein homeostasis and cancer cell proliferation, the ATPase p97 in complex with its cofactors such as Npl4 has been intensively investigated as a drug target. However, whether p97 plays a role in immune cells is unclear. Instead of directly inhibiting p97 enzymatic activity as usual, here we first performed an AlphaScreen using purified recombinant proteins of p97 and Npl4, which identified thonzonium bromide (TB), an FDA-approved drug, as an inhibitor for p97-Npl4 interaction; then by serendipity we discovered an essential role for the p97-Npl4 complex in TI-Treg; and finally, we demonstrated a highly selective effect of TB on boosting antitumor immunity alone or in combination with anti-PD-1 immunotherapy. Mechanistically, the p97-Npl4 complex was found to bridge Stat3 with E3 ligases PDLIM2/5, thereby promoting Stat3 degradation. TB inhibition of the p97-Npl4 interaction caused Stat3 accumulation to block TI-Treg but promote Th17 development. Notably, TB selectively reshaped tumor microenvironment without affecting immune homeostasis outside of tumor. Collectively, this work revealed a key role for the p97-Npl4 complex in controlling the TI-Treg-Th17 balance, offering a new type of antitumor immunotherapy with oral administration of TB.
A hybrid Model for The Detection of Retinal Disorders Using Artificial Intelligence Techniques
Authors: Salaheldin Ahmed M. , Wahed Manal Abdel , Saleh Neven 
Published: August 2023

Abstract

The prevalence of vision impairment is rising at an alarming rate. The goal of the study is to create an automated method that uses Optical Coherence Tomography (OCT) to classify retinal disorders into four categories, namely, Choroidal Neovascularization, Diabetic Macular Edema, Drusen, and normal cases. The study proposed a new framework that combines machine learning and deep learning-based techniques. The utilized classifiers were Support Vector Machine (SVM), K-Nearest Neighbor (K-NN), Decision Tree (DT), and Ensemble Model (EM). A feature extractor was also employed, which was the InceptionV3 convolutional neural network. The performance of the models has been measured over nine criteria using a dataset of 18000 OCT images. For the SVM, K-NN, DT, and EM, the analysis exhibited state-of-the-art performance with classification accuracies of 99.43%, 99.54%, 97.98%, and 99.31%, respectively. A promising methodology has been introduced for the automatic identification and classification of retinal disorders leading to reducing human error and saving time alike.
Predictors of Anthracycline-inducedcardiotoxicity in Lymphoma Patients: A Retrospective Cohort Study
Authors: LOPEZ-GARCIA A. , MACIA E. , GOMEZ-TALAVERA S. , CASTILLO E. , MORILLO D. , TUÑON J. , IBAÑEZ B. , CORDOBA R. 
Published: August 2023

Abstract
Background: Anthracycline-induced cardiotoxicity (CT) is a growing concern for public health, with a growing incidence due to improved survival rates for patients with hematological malignancies due to diagnostic and therapeutic advances. Identification of patients at risk for anthracycline-induced CT is vital to develop preventive strategies.
Methods: A single-center retrospective cohort study was conducted between 1 January 2017 and 15 February 2023. Medical records of patients with lymphoma treated with first-line anthracyclines were reviewed. Demographic data, cardiovascular risk factors, biomarkers of myocardial damage and echocardiographic information were collected.
Results: A total of 200 patients were included. The incidence of CT was 17.4 % (35/200). Patients with CT were older than those without CT, with a mean age of 65.17 years vs 56.77 (p = 0.008). Dyslipidemia (DL) (31.4% vs 13.4% p = 0.017) and previous cardiovascular disease (40% vs 13.3%, p< 0.001) were more frequent in the group who developed an event. Mean baseline NT-proBNP levels in the subgroup with cardiovascular events were 388.73 kg /L ± 101.02, and 251.518 kg /L ± 26.22 in those who did not (p = 0.004). Differences in Troponin I levels were identified during and after treatment without exceeding the laboratory’s upper reference limit. Patients were followed for a median of 51.83 months (0.76-73.49). The presence of a CT event had a negative impact on overall mortality from any cause (HR = 2.23 (95% CI 1.08-2.93), p = 0.031).
Conclusions: Early identification of risk factors is crucial to manage patients at risk for anthracycline-induced cardiotoxicity.
A new screen-printed carbon sensor decorated gold nanoparticles/kaolinite mineral: electrochemical analysis of Propyphenazone and the investigation of ds-DNA interaction
Authors: Yıldız Ceren , Bayraktepe Dilek Eskiköy , Yazan Zehra 
Published: August 2023

Abstract

This work represents the development of natural kaolinite mineral (Kao)−gold nanoparticles (GNPs) modified screen-printed carbon electrode (SPCE) based on biocompatible electrode material for the electrochemical quantification of Propyphenazone (PROP) and the investigation of the interaction between PROP and ds-DNA. The surface characteristics of the Kao−GNPs/SPCE were examined by Cyclic Voltammetry (CV), Electrochemical Impedance Spectroscopy (EIS), and Field-Emission Scanning Electron Microscopy (FE-SEM) with Energy Dispersive X-ray Spectroscopy (EDS) methods. The effect of Kao and gold compositions, pH, and interferences studied the analytical performance of this sensor. PROP has an irreversible oxidation signal on Kao−GNPs/SPCE sensor surface. Based on this oxidation signal, calibration works were carried out using differential pulse voltammetry (DPV), and linear working range, LOD, and LOQ were determined. The real sample analysis of PROP was implemented in human serum samples with a recovery value of 99.43%. Binding constant (K) and Gibbs free energy change (ΔG°) relating to the interaction between PROP and ds-DNA were calculated to be 2.14 (± 0.42) × 104 M− 1 and − 24.70 kJ mol− 1, respectively.