bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring DNA methylation data for diagnostic classification of Diffuse large B-cell lymphoma in Dogs
Authors: Giwa Abdulazeez , Adu Oluwaseun 
Published: February 2023

Abstract
Diffuse large B-cell lymphoma (DLBCL) is a common B-lymphocyte tumor in dogs, making up 60-70% of cases. We assessed the utility of DNA methylation data for the diagnostic classification of DLBCL in dogs. We also assessed the utility of the classification features identified in cDLBCL for diagnostic classification of DLBCL in humans. The GSE94913 cDLBCL DNA methylation dataset from the Gene Expression Omnibus (GEO) was used for analysis. Differential methylation analysis was performed between the 37 cDLBCL and seven control lymph node samples in the dataset. 1701 differentially methylated probes were identified between the cDLBCL and control lymph nodes groups. Applying recursive feature elimination on the 1701 significant probes, 20 probes were selected for machine learning classification tasks. The methylation values of these 20 probes were used to build an SVM model and create the training and testing set. 100% of the test samples were accurately classified by the SVM model. The diagnostic classification utility of the identified differentially methylated CpGs/CDS was also assessed in humans using the GSE28094 human DLBCL dataset. 95% of 98 DLBCL and leukocyte samples obtained from this dataset was correctly classified using clustering techniques on 11 CpG sites of 5 genes (ERBB4, IGF2, PGF, PITX2, TJP1). The utility of DNA methylation data for the diagnostic classification of DLBCL in dogs is demonstrated. Further exploration of this data type for potential biomarker discovery in cDLBCL is necessary.
Enterocytozoon bieneusi Infection in Livestock from selected farms in Lagos, Nigeria
Authors: Oladele Ojuromi T. , Fernando Izquierdo , Fenoy Soledad , Carmen del Aguila 
Published: February 2023

Abstract

Microsporidia are enteric intracellular pathogens infecting animals and humans. It causes life-threatening diarrhoea in humans. Microsporidia species have been isolated from several domestic and wild animals, however, data on microsporidia infection in animals in Nigeria is still very scanty. This study was conducted to clarify and improve our knowledge of the possibility of the zoonotic origin of Enterocytozoon species in the environment. Two hundred and fifty (250) animal faecal samples from various farm animals were examined for their frequency of microsporidia spores using Weber’s chromotrope stain and Indirect Fluorescence Antibody Test (IFAT). Enterocytozoon bienuesi were detected in 6 (24.0%) turkeys, 2 (8.0 %) goats, 3(12.0 %) cattle, and 4(16.0%) rams. No reactivity was detected with other species of microsporidia by IFAT. This study confirms the presence of E. bienuesi in the animals examined and shows that animals can be a significant source of zoonotic transmission in the environment.
Spiraea decumbens Koch subsp. tomentosa (Poech) Dostál, novelty for the flora of Slovenia and the Dinaric Alps
Authors: Dakskobler Igor 
Published: February 2023

Abstract
In Govci under Mt. Poldanovec above the Trebuša Valley we found a new locality of southeastern-Alpine (Alpic) endemic Spiraea decumbens subsp. tomentosa, which is new to the flora of Slovenia and the Dinaric Alps. Its closest known localities are in the western Julian Prealps in Northeastern Italy. A small population of several ten shrublets occurs at elevations of about 570 m in shady, almost vertical dolomite rocks, in a stand of the endemic association Phyteumato columnae-Primuletum carniolicae. Despite a very small population we assume there are other localities in this area, where numerous gorges are very difficult to acces and have therefore not yet been sufficiently studied.
Carex × takhtadjanii (Carex diluta × C. distans; Cyperaceae), a new hybrid for the flora of Ukraine
Authors: Peregrym Mykyta , Koopman Jacob 
Published: February 2023

Abstract
There are 96 species of the genus Carex (Cyperaceae) known in the flora of Ukraine, but so far there are no data about its hybrids for the country yet. However, the first one, C. × takhtadjanii [C. diluta × C. distans], was discovered in Starobilsk town (Luhansk region) during a field investigation in 2021. Detailed information about this floristic finding with the description of morphological characters of this hybrid and its habitat is given. Also a map with known locations of C. × takhtadjanii around the world is compiled, as well as the main morphological differences between this hybrid and its parental species are reported.
Phenotypic diversity of natural populations of an endemic Moroccan plant (Euphorbia resinifera O. Berg)
Authors: Abd-dada Hassane , Bouda Said , Aitbella Youssef , Haddioui Abdelmajid 
Published: February 2023

Abstract
The Euphorbia resinifera is melliferous and medicinal plant and one of the endemic species of Moroccan Atlas Mountains. It is very well known for its honey of high nutritional and therapeutic quality. The objective of our study is to characterize and evaluate the phenotypic variation of this spontaneous species. Seventeen qualitative and quantitative morphological characters related to the bush, stem, spine, flower, and fruit of the plant were used to assess the morphological variability of twelve natural populations collected from its geographical range in Morocco. The results of the analysis of variance showed significant differences between the studied populations for the most examined traits reflecting the existence of a high phenotypic variability within this species. The principal component analysis showed that E. resinifera populations were clustered in three distinct groups not related to mountain range type. The results highlight a high phenotypic diversity within studied populations of this species in Morocco. This work aims to study the phenotypic variability of E. resinifera to delineate conservation strategies and also to establish forms of rational economic exploitation.
Molecular microbiological characteristics of gingival pockets in the periodontal diseases of dogs
Authors: Polkowska Izabela , Tymczyna-Borowicz Barbara , Gołyńska Magdalena , Nowicka Beata 
Published: February 2023

Abstract

Introduction
Canine periodontitis results among other factors from a disturbed balance of dental plaque microflora and an inadequate host inflammatory response to a stimulus. This investigation sought to identify microorganisms associated with canine periodontitis.

Material and Methods
Microbiological analysis was undertaken of gingival pockets in an experimental group of 36 dogs with periodontal diseases. Swabs were collected with the use of Pet Test (MIP Pharma, Berlin, Germany) from patients with gingival pockets deeper than 5 mm. Samples were aggregated and placed in separate shipping containers with the Pet Test kit.

Results
Identification was made of the most common microorganisms, e.g. Porphyromonas gingivalis, Treponema denticola and Prevotella intermedia. The red complex constituted the largest proportion of all analysed organisms (84.26%). Capnocytophaga gingivalis was isolated from 33 dogs, Peptostreptococcus micros from 32 dogs, Fusobacterium nucleatum from 29 animals and P. intermedia from 20.

Conclusion
The highest percentage of pathogens was supplied by P. gingivalis (61%). It is thought that dogs acquire them by means of cross-species transmission. The inter-study variability of results may depend not only on the method of periopathogen detection, but also on environmental factors, host immune status or genetic background. Depending on the state of periodontal disease, patients show varied microbiological profiles of the gingival pockets.
RheumCloud App: A novel mobile application for the management of rheumatic diseases patients in China
Authors: Huang Can , Zhao Jiuliang , Tian Xinping , Wang Qian , Xu Dong , Li Mengtao , Zeng Xiaofeng 
Published: February 2023

AbstractThis review summarizes the history, function, application, and achievement of the RheumCloud App as a novel smartphone application. This App reflects the development of the Chinese Rheumatism Data Center (CRDC), which provides not only a technical platform for the database and registry of rheumatic diseases (RDs) in China, but also a close tie between Chinese rheumatologists and patients with RDs. Throughout the past decade, CRDC has successfully built the world’s largest nationwide database for RDs. A total of 2074 tertiary referral centers consisting of 8051 rheumatologists participated in the registry. RheumCloud App, which is representative of the success of CRDC, has played a central role in supporting patient cohort registration, biosample collection, and patient education. Based on the data of the Rhuem-Cloud App, three national key research projects have been funded and a series of research papers have been published.
Echo Answers in Chinese
Authors: Wei Ting-Chi 
Published: February 2023

Abstract
This paper studies echo answers to yes-no questions in Chinese with respect to their distributions, derivations, and typological patterns. We reconsider Simpson’s (2015) verb-raising analyses of verb echo answers (VEAs), finding that his analysis is inspiring in describing the significant properties of VEAs but that he has not discussed issues pertinent to the role of le in VEAs, adverbial echo answers, and multiple verb echo answers. This paper proposes that the derivation of short echo answers in Chinese is two-fold: the verb echo answer involves V-to-v movement, pro-drop, and VP-deletion; and the adverbial short answer involves focus movement and TP deletion. The aspectual markers, the post-verbal le1 denoting perfective and the sentence-final le2 encoding a change of state in Chinese, play a crucial role in determining the grammaticality of certain verb-echo answers via aspectual anchoring. This analysis avoids analytical problems posed by V-to-C (domain) (Holmberg 2016; Simpson 2015, etc.). Evidence from information focus and negative scope reversal supports this two-track analysis of echo answers in Chinese. Finally, we conclude that typologically, Chinese, a language using verb-echo answers, is close to Vietnamese and Finnish in allowing adverbial short answers and akin to Thai and Finnish in allowing multiple verb echo answers.
Pengaruh Pertumbuhan, Leverage, Profitabilitas, dan Kebijakan Dividen terhadap Nilai Perusahaan
Authors: Timotius Timotius , Setyawan Ignatius Roni 
Published: February 2023

Penelitian ini bertujuan untuk memperoleh bukti empiris atas pengaruh dari pertumbuhan, leverage, profitabilitas dan kebijakan dividen terhadap nilai perusahaan pada perusahaan manufaktur di Bursa Efek Indonesia (BEI) tahun 2017-2020. Penelitian ini menggunakan 144 data sampel yang dipilih melalui metode purposive sampling dari 36 perusahaan. Data penelitian diolah menggunakan Eviews 9.0. Hasil penelitian membuktikan bahwa pertumbuhan berpengaruh positif dan signifikan terhadap nilai perusahaan, leverage berpengaruh positif dan signifikan terhadap nilai perusahaan, profitabilitas berpengaruh positif dan signifikan terhadap nilai perusahaan dan kebijakan dividen berpengaruh positif dan signifikan terhadap nilai perusahaan.

This research is made to obtain empirical evidence about the effect of growth, leverage, profitability, and dividend policy on firm value on manufacture companies in the Indonesian Stock Exchange in the period of 2017-2020. This research is conducted by taking 144 sample determined by purposive sampling method of 36 companies. Research data is processed using Eviews 9.0. The result indicate that growth has positive and significant effect on firm value, leverage has positive and significant effect on firm value, profitability has positive and significant effect on firm value and dividend policy has positive and significant effect on firm value.
Santripreneur at Al-Ustmani: Efforts to Realize Sharia-Based Entrepreneurship in Islamic Boarding Schools
Authors: Adinugraha Hendri Hermawan 
Published: February 2023

Abstrak Penelitian ini memiliki maksud untuk menjabarkan santripreneur di Al-Ustmani dalam upaya untuk mewujudkan kewirausahaan berbasis syariah di pondok pesantren. Pendekatan yang digunakan penulis yaitu pendekatan kualitatif. Teknik pengumpulan data yang digunakan dalam penelitian yaitu participan observation, in depth interview dan document review. Teknik pengolahan data dilakukan melalui tahapan editing dan organizing. Analisis data kualitatif mengikuti konsep Miles and Huberman and Spradeley. Teknik pengecekan keabsahan data adalah dilakukan dengan triangulasi. Hasil temuan penelitian ini menunjukkan bahwa kegiatan kewirausahaan yang ada di Al-Ustmani sudah mampu menumbuhkan jiwa wirausaha santri. Kegiatan kewirausahaan di Al-Ustmani juga menanamkan nilai-nilai kewirausahaan berbasiskan ekonomi syariah. Aktivitas kewirausahaan dalam perspektif ekonomi Islam seringkali dipraktikkan oleh Nabi, istrinya, para sahabat, dan juga para pengikutnya. Karena Islam bukan hanya mengkaji tentang entrepreneurship, tetapi langsung mempraktikkannya dalam kehidupan nyata. Al-Ustmani telah menyiapkan program kegiatan pembelajaran yang sungguh-sungguh dapat mendorong tumbuh dan berkembangnya spirit kewirausahaan para santri agar menjadi Santripreneur.Abstract This study aims to describe the santripreneurs in Al-Ustmani in an effort to realize sharia-based entrepreneurship in Islamic boarding schools. The approach used by the author is a qualitative approach. Data collection techniques used in the study were participant observation, in-depth interviews and document review. Data processing techniques are carried out through editing and organizing stages. Qualitative data analysis follows the concept of Miles and Huberman and Spradeley. The technique of checking the validity of the data is done by tringulation. The findings of this study indicate that entrepreneurial activities in Al-Ustmani have been able to foster the entrepreneurial spirit of students. Entrepreneurial activities at Al-Ustmani also instill entrepreneurial values based on sharia economics. Entrepreneurial activities in the perspective of Islamic economics are often practiced by the Prophet, his wife, his companions, and also his followers. Because Islam is not only studying entrepreneurship, but directly practicing it in real life. Al-Ustmani has prepared a program of learning activities that can truly encourage the growth and development of the entrepreneurial spirit of the students to become Santripreneurs.
Non-Muslim Determinants Using Islamic Financial Institutions
Authors: Zein Aliman Syahuri 
Published: February 2023

Abstrak Lembaga keuangan syariah memiliki market share yang cukup besar, terdiri dari masyarakat Muslim maupun non Muslim. Berdasarkan data yang ada, jumlah non Muslim di Padangsidimpuan mencapai 8,27% dari total jumlah penduduk. Namun yang telah menjadi nasabah lembaga keuangan syariah belum mencapai 10% dari jumlah yang ada. Tujuan penelitian menganalisis pengaruh lokasi, pelayanan, fasilitas, keuntungan, religiusitas, produk, dan promosi terhadap perilaku nasabah. Penelitian ini merupakan jenis penelitian kuantitatif, dengan menggunakan analisis regresi linier berganda. Sampel penelitian berjumlah 57 orang nasabah non Muslim. Teknik sampling yang digunakan adalah acidental sampling. Hasil penelitian menyimpulkan bahwa secara parsial lokasi, fasilitas, stimulan religi, dan produk tidak memiliki pengaruh yang signifikan terhadap keputusan non Muslim memilih lembaga keuangan syariah di Padangsidimpuan. Sementara itu, secara parsial pelayanan, keuntungan, dan promosi memiliki pengaruh yang signifikan terhadap keputusan non Muslim memilih lembaga keuangan syariah di Padangsidimpuan. Namun secara simultan, semua variabel bebas memiliki pengaruh signifikan terhadap variabel terikat. Abstract Islamic financial institutions have a large market share, consisting of Muslim and non-Muslim communities. Based on existing data, the number of non-Muslims in Padangsidimpuan reaches 8.27% of the total population. However, those who have become customers of Islamic financial institutions have not yet reached 10% of the existing amount. The research objective is to analyze the effect of location, service, facilities, benefits, religiosity, product and promotion on customer behavior. This research is a type of quantitative research. The research sample is 57 non-Muslim. The sampling technique used is accidental sampling. The results, that partially location, facilities, religious stimulants, and products did not have a significant effect on the decision of non-Muslims to choose an Islamic financial institution. Meanwhile, partially, services, benefits, and promotions have a significant influence on the decision of non-Muslims to choose Islamic financial institutions. But simultaneously, all independent variables have a significant influence on the dependent variable.
Studi Penambatan Molekuler dan Simulasi Dinamika Molekuler Senyawa Turunan Furanokumarin terhadap Reseptor Estrogen Alfa (ER-α) Sebagai Anti Kanker Payudara
Authors: Elfita Lina , Apriadi Anjas , Supandi Supandi , Dianmurdedi Shanifa 
Published: February 2023

Kanker payudara menjadi salah satu jenis kanker dengan penderita terbanyak baik di dunia maupun di Indonesia, Reseptor Estrogen Alfa (ER-α) menjadi target utama karena dapat mengatur transkripsi gen dan jalur persinyalan interseluler. Penelitian ini bertujuan untuk menganalisis afinitas dan kestabilan ikatan kompleks ligan senyawa turunan furanokumarin dengan reseptor estrogen alfa. Metode yang digunakan secara in silico atau komputasi yaitu penambatan molekuler menggunakan software AutoDock dan simulasi dinamika molekuler menggunakan software Gromacs. Hasil penambatan molekuler senyawa Bergamottin sebagai senyawa uji paling baik dengan nilai ∆G = -8,98 kkal/mol. Sedangkan ligan pembanding 4-Hydroxytamoxifen dengan nilai ∆G = -11,34 kkal/mol. Hal tersebut menunjukkan bahwa afinitas 4-Hydroxytamoxifen masih lebih baik daripada Bergamottin. Kestabilan ikatan ligan-reseptor dikonfirmasi dengan simulasi dinamika molekuler menunjukkan 4-Hydroxytamoxifen lebih stabil berikatan dengan ER-α berdasarkan parameter Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), Radius of Gyration dan ikatan hidrogen. 4-Hydroxytamoxifen memiliki afinitas dan kestabilannya lebih baik dalam berikatan dengan reseptor estrogen alfa (ER-α)
Measurements of T5 Shock Tunnel Freestream Temperature, Velocity, and Composition
Authors: Finch Peter M. , Girard Julian J. , Schwartz Tal , Strand Christopher L. , Hanson Ronald K. , Yu Wesley M. , Austin Joanna M. , Hornung Hans G. 
Published: February 2023

We report on measurements of rotational and vibrational temperature, velocity, and concentrations of nitric oxide (NO) in freestream flows at the T5 reflected shock tunnel at California Instistute of Technology. Quantities were measured at 50 kHz by tunable diode laser absorption spectroscopy using five lasers simultaneously to sample 27 quantum state-specific transitions. To isolate core flow measurements from the shear flow surrounding it, optical flow-cutter arms were designed. Two sets of arms with differing optical path lengths were used to assess freestream spatial uniformity. This study consists of nine total experiments (“shots”) spanning four nominal conditions with reservoir enthalpy 8–21 MJ/kg and flow velocity 3.5–5.5 km/s. Freestream measurements generally imply thermal equilibrium of the rotational and vibrational temperatures except at lower-enthalpy conditions. We compare temperature measurements with predictions from five species air simulations and find reasonable agreement at lower-enthalpy conditions but underprediction of NO concentrations. At higher-enthalpy conditions, we observed transitory agreement in temperature but overprediction of NO concentrations. Measured and simulated velocity generally agree well across all conditions. Carbon monoxide, water, and potassium were also detected in the T5 flow, and their concentrations are reported where relevant.
Knowledge, Attitudes, Practices and Mental Health Status of Trainees in Selected Health Institutes Regarding COVID-19 in Uttar Pradesh, India
Authors: Bhoil Rohan , Paul Budhaditya , Srivastava Ankita 
Published: February 2023

On 11 March 2020, the World Health Organization (WHO) declared the novel coronavirus (COVID-19) outbreak a global pandemic. Knowledge about COVID-19 is an important determinant towards successful disease control. This study was designed to elucidate the knowledge, attitudes and practices (KAP) and mental health status regarding COVID-19 amongst trainees of two institutes in the state of Uttar Pradesh, India. The cross-sectional study was conducted from January to March 2021. A bilingual survey recorded the responses of 400 participants from the institutes. Variables, such as sex, age, marital status, occupation, level of education, number of family members and living place, were collected in a structured proforma. Unstandardised regression coefficients (95%) were used for evaluating the association among variables with KAP and mental health during COVID-19. The statistical significance level was determined at p<0.05.The mean correct answer score regarding knowledge about COVID-19 was 23.5 (SD=2.1), indicating an overall 87% correct rate. The mean correct answer score regarding attitude towards COVID-19was 18.4 (SD=2.3), indicating an overall 87.2% correct rate. The mean correct answer score regarding practice towards COVID-19 was 35 (SD=3.4), indicating an overall 89.7% correct rate. The mean correct answer score regarding mental health status during COVID-19 was 24 (SD=4.7), indicating an overall 80% correct rate. Thus, the results showed that being female; belonging to a higher age group; having a healthcare related occupation; being married; and having a higher level of education were significantly associated with higher KAP test scores. Furthermore, belonging to a higher age group; having a healthcare related occupation; being married; and having a higher level of education were significantly associated with poor mental health.
Features of the Style of the Letters of Bishop Theophan the Recluse: Lexical and Phraseological Aspects
Authors: Yao Song 
Published: February 2023

Purpose. The purpose of this article is to analyze the characteristics of lexical terms in Russian texts from the perspective of lexical rhetoric. So the article analyzes the peculiarities of the vocabulary and phraseology of the letters from “Letters on the Christian Life” of the famous preacher, religious teacher Bishop Theophan the Recluse.Results. Through the analysis of the selected specific vocabulary and idioms, we have obtained the following results. One of the distinguishing features of these epistolary texts is polystylism, which manifests itself in a free combination of vocabulary of foreign origin, colloquial words, and Church Slavonicisms. If borrowed vocabulary is used in a stylistically neutral function, then colloquial elements are stylistically marked and used in order to establish communication with addressees. Such vocabulary creates a kind of trusting relationship between the addresser and addressees. Phraseological units and constructions, which are author’s, occasional transformations of phraseological elements, serve the same purpose. Church Slavonic inclusions in letters are a kind of communicative fragments, intexts within letters, conditioned in thematic (definitions of theological concepts) and genre (quotations from the Bible and prayer addresses).Conclusion. In summary, through this research, we can derive some new theories of linguistic application, and through it, we can enrich the interpretation of corpus and dictionaries.