bluuebunny/crossref_metadata_2025_split huggingface dataset:
Footprints of stress in vitiligo: Association of the 5-HTR2C rs6318 variant
Authors: Yilmaz Izel , Yazici Serkan , Ergoren Mahmut Cerkez , Baskan Emel Bulbul , Oral Haluk Barbaros , Aydogan Kenan , Temel Sehime Gulsun 
Published: March 2023

Abstract

Vitiligo is a chronic autoimmune progressive dermatological disease and stress known to have impact on the development of vitiligo. However, the effect of serotonin has not been clearly explained for disease progression. Therefore, this study aimed to clarify stress induced 5-HTR2C rs6318 variant and its association with vitiligo pathogenesis.
Study conducted with 108 vitiligo patients and 107 age-sex matched, unrelated healthy subjects as control group. Real Time-PCR analysis method was used for genotyping the 5-HTR2C variation. Genotype and allele frequencies considered for both control and patient groups. Genotype distributions for the Hardy-Weinberg Equilibrium (HWE) were analyzed. Vitiligo-related risk measures of different genotype combinations examined. Genotype correlations of the variant also analyzed based on gender difference, age onset of vitiligo, Koebner phenomenon history, clinical subgroups, treatment types, presence of other autoimmune diseases, vitiligo presence in family members and other autoimmune diseases in relatives.
No statistically significant difference in 5HT-R2C receptor genotypes and allele frequencies between patient and control has been found. Genotype frequencies were not in agreement with the Hardy-Weinberg Equilibrium in the patients’ group (p < 0.00001). Frequency of the risk allele (allele C) was not significantly different between the patient and control groups (p = 0.1392). However, in the clinical subgroup analysis, the risk allele presence detected significantly higher for early age onset (< 40 years) vitiligo development (p = 0.0365) and lower in Koebner phenomenon history (p = 0.0276).
As a result, although there was no association between the 5-HTR2C variant rs6318 and vitiligo, the current results indicated that there is a strong association between the 5HTR2C rs6318 variant C allele and early age onset vitiligo development.
Cumhuriyet Halk Partisi İktidarı Döneminde Büyük Doğu’nun Türk İnkılabına Bakışı (1943-1950)
Authors: GÖK Hacı Veli 
Published: March 2023

26 Mayıs 1904 tarihinde İstanbul’da dünyaya gelen Necip Fazıl Kısakürek düşünsel, ideolojik, edebi ve politik arenada Türk toplumu üzerinde önemli bir etkiye sahip olmuştur. Kısakürek yaşamının bir bölümünü özellikle 1943 yılında Büyük Doğu Dergisi’ni çıkarana dek katı bir İslami ideolojiden uzak geçirirken özellikle Abdülhakim Arvasi ile tanışması ve ardından gelen süreçte Büyük Doğu Dergisi’ni çıkarması ile birlikte CHP ve Türk inkılabına karşı eleştirel bir tavır takınmıştır. Çalışmanın konusunu teşkil eden Büyük Doğu Dergisi’nin Türk inkılabına karşı bakışı çerçevesinde Kısakürek’in Büyük Doğu Dergisi aracılığı ile Türk inkılabına karşı sert bir tavır takındığı görülmektedir. Kısakürek’in ve Büyük Doğu Dergisi’nin Türk inkılabına karşı takınmış olduğu bu sert tavrın muhtevasını ise yapılan inkılapların madde planında kaldığı ve manevi anlamda Türk milletine hitap etmediği yönünde düşünceler oluşturmaktadır. Öyle ki, Büyük Doğu Dergisi, madde planında kurtarılmış olan vatanın manevi planda İslam ile uyuşmadığını, inkılapların Türk milletinin talep ve ısrarı üzerine değil jakoben bir yöntemle uygulamaya sunulduğunu bundan dolayı da Türk milleti nezdinde kabul görmediğini iddia etmiştir.
Öte yandan inkılapların Batı temelli bir yaklaşımla tatbik edilmesinin eleştirildiği Büyük Doğu Dergisi’nde bu gibi yaklaşımların “kopyacılıktan” ibaret olduğu ve Türk milletinin ruh planına kesinlikle uygun olmadığı da sıklıkla dile getirilmiştir. Büyük Doğu Dergisi’nin inkılaplar karşısındaki bu sert tutumu muhtelif tarihlerde derginin kapatılması ile sonuçlanmış ancak dergi kapatma kararlarından bir süre sonra tekrardan açılmıştır. Burada dikkat çekilmesi gereken nokta derginin tekrardan açıldığı tarihlerde kapatma gerekçelerine neden olan değerlendirmeleri yinelemesi ve CHP’nin iktidar olduğu dönemde CHP’yi ve inkılapları sert bir şekilde eleştirmesidir. Şüphesiz ki, Büyük Doğu Dergisi’nin CHP ve inkılaplara karşı takınmış olduğu sert tavır devlet mekanizmasını harekete geçirmiş, derginin CHP iktidarı ile iyi ilişkiler kuramamasına neden olmuş, Necip Fazıl Kısakürek ve derginin Devletin yakın takibine alınmasına yol açmıştır. Bu bağlamda çalışma, Cumhuriyetin ve inkılapların halka benimsetilmeye çalışıldığı CHP iktidarı döneminde Büyük Doğu Dergisi ile devlet mekanizması arasındaki çekişmenin ayrıntılı bir şekilde ortaya konulması açısından önem arz etmektedir
COVID Vaccines vs. Viral Evolution: Who Will Win the Battle?
Authors: Sharma Sahil , Sood Vikas , Sharma Deepak 
Published: March 2023

Abstract:
The emergence of new variants seems to perpetually prolong the COVID-19 pandemic. On top of that, the waning of vaccine protection is further thwarting our efforts to end it. Our article discusses the incessant question raging in everybody’s mind: Are we ever going to win?
MiRNAs Overexpression and Their Role in Breast Cancer: Implications
for Cancer Therapeutics
Authors: Lee Sau Har , Ng Chu Xin , Wong Sharon Rachel , Chong Pei Pei 
Published: March 2023

Abstract:
MicroRNAs have a plethora of roles in various biological processes in the cells and
most human cancers have been shown to be associated with dysregulation of the expression of miRNA
genes. MiRNA biogenesis involves two alternative pathways, the canonical pathway which requires
the successful cooperation of various proteins forming the miRNA-inducing silencing complex
(miRISC), and the non-canonical pathway, such as the mirtrons, simtrons, or agotrons pathway,
which bypasses and deviates from specific steps in the canonical pathway. Mature miRNAs
are secreted from cells and circulated in the body bound to argonaute 2 (AGO2) and miRISC or
transported in vesicles. These miRNAs may regulate their downstream target genes via positive or
negative regulation through different molecular mechanisms. This review focuses on the role and
mechanisms of miRNAs in different stages of breast cancer progression, including breast cancer
stem cell formation, breast cancer initiation, invasion, and metastasis as well as angiogenesis. The
design, chemical modifications, and therapeutic applications of synthetic anti-sense miRNA oligonucleotides
and RNA mimics are also discussed in detail. The strategies for systemic delivery
and local targeted delivery of the antisense miRNAs encompass the use of polymeric and liposomal
nanoparticles, inorganic nanoparticles, extracellular vesicles, as well as viral vectors and viruslike
particles (VLPs). Although several miRNAs have been identified as good candidates for the design
of antisense and other synthetic modified oligonucleotides in targeting breast cancer, further efforts
are still needed to study the most optimal delivery method in order to drive the research beyond
preclinical studies.
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and
Experimental Approaches
Authors: Mares Catalina , Udrea Ana-Maria , Buiu Catalin , Staicu Angela , Avram Speranta 
Published: March 2023

Abstract:
Compounds from plants that are used in traditional medicine may have medicinal properties.
It is well known that plants belonging to the genus Aconitum are highly poisonous. Utilizing
substances derived from Aconitum sp. has been linked to negative effects. In addition to their toxicity,
the natural substances derived from Aconitum species may have a range of biological effects on
humans, such as analgesic, anti-inflammatory, and anti-cancer characteristics. Multiple in silico, in
vitro, and in vivo studies have demonstrated the effectiveness of their therapeutic effects. In this review,
the clinical effects of natural compounds extracted from Aconitum sp., focusing on aconitelike
alkaloids, are investigated particularly by bioinformatics tools, such as the quantitative structure-
activity relationship method, molecular docking, and predicted pharmacokinetic and pharmacodynamic
profiles. The experimental and bioinformatics aspects of aconitine’s pharmacogenomic
profile are discussed. Our review could help shed light on the molecular mechanisms of Aconitum
sp. compounds. The effects of several aconite-like alkaloids, such as aconitine, methyllycacintine, or
hypaconitine, on specific molecular targets, including voltage-gated sodium channels, CAMK2A
and CAMK2G during anesthesia, or BCL2, BCL-XP, and PARP-1 receptors during cancer therapy,
are evaluated. According to the reviewed literature, aconite and aconite derivatives have a high affinity
for the PARP-1 receptor. The toxicity estimations for aconitine indicate hepatotoxicity and
hERG II inhibitor activity; however, this compound is not predicted to be AMES toxic or an hERG I
inhibitor. The efficacy of aconitine and its derivatives in treating many illnesses has been proven
experimentally. Toxicity occurs as a result of the high ingested dose; however, the usage of this
drug in future research is based on the small quantity of an active compound that fulfills a therapeutic
role.
Overcoming the Limitations of Therapeutic Strategies to Combat Pancreatic
Cancer using Nanotechnology
Authors: Dhoundiyal Shivang , Alam Md. Aftab 
Published: March 2023

Abstract:
Resistance to conventional antitumour therapies and Hypoxia in patients with advanced
solid tumours are two major reasons for the failure of conventional anti-tumour therapies. Therefore,
it is important to find a new therapeutic method that can overcome these problems. An attenuated anaerobic
bacterium, Clostridium novyi-NT, could target Hypoxic and Necrotic areas of tumours causing
tumour lysis and stimulating a host anti-tumour immune response. To the best of our knowledge,
the combination of bacterial anti-tumour therapy, chemotherapy, radiotherapy and immunotherapy
may promote tumour regression, inhibit metastasis and develop a new strategy for the treatment of
solid tumours. However, the possible molecular mechanisms of the combined therapies are still the
biggest challenge. This review provides an overview of the history of bacterial cancer therapy and the
development of a non-lethal strain of Clostridium novyi. Below is a precise definition of Hypoxic
conditions in solid tumour tissue. To understand the anticancer effect of Clostridium novyi-NT spores,
possible cell death mechanisms were summarised by the enzyme phospholipase C (nt01cx0979),
which is secreted by Clostridium novyi-NT spores after germination in tumour tissue. The function of
Clostridium novyi-NT spores in stimulating the host immune system to elicit anti-tumour responses
was reviewed. Then, the results of anti-tumour combination therapies based on Clostridium novyi-NT
spores were compiled. Identifying the molecular mechanisms of Clostridium novyi-NT in treating tumours
and inducing cell death in invasive cancer cells, ultimately leading to tumour regression, may
develop promising clinical strategies in the combined treatment of solid tumours.
Recent Advancements in Light-responsive Supercapacitors
Authors: Shah Syed Shaheen , Aziz Md. Abdul 
Published: March 2023

Abstract:
With so many of our daily activities related to electricity, from telecommunication to
laptops and computers, the use of electric energy has skyrocketed in today's technology-based
world. Energy output must rise to meet rising energy demand. Still, as fossil fuels are running
out, we must turn to more renewable energy sources, particularly solar energy, which can be
harnessed and converted to electricity by solar-powered cells. The issues, however, are brought
about by the sunlight's unpredictable energy output. The energy produced by solar cells should
therefore be stored using energy storage technologies. This notion led to the development of the
photo-supercapacitor, a device that combines a solar cell with a supercapacitor to store the energy
generated by the solar cells. However, recently researchers developed light-responsive materials
for supercapacitors that could be used directly as electrode materials and deposited on various
transparent and conductive substrates. Such light-responsive supercapacitors could be operated
directly by shining solar light without using any solar cell. A light-responsive supercapacitor's
efficiency is primarily influenced by the active materials used in its electrode fabrication.
The main components of high-energy conversion, which improves a light-responsive supercapacitor's
performance and shelf life, are photoactive materials, counter electrodes, compatible
electrolytes, and transparent substrate performances. Furthermore, light-responsive supercapacitors
are cutting-edge and promising energy storage devices that can self-charge under light illumination
by converting light to electrical energy and storing it for later use. They are considered
a novel approach to energy issues in electrical transportation, electronic equipment, and on-chip
energy storage devices. Thus, this review paper opens up an avenue for the direct utilization of
photoactive nanomaterials for electrochemical energy storage and demonstrates the substantial
potential for the fabrication of advanced light-responsive supercapacitors. This study also covers
the fundamentals of how this exciting field works, the historical trajectory of how far it has
come, and the promising prospects for its future.
The Sustained-released Polylactic Co-glycolic Acid Nanoparticles Loaded
with Chlorhexidine as Antibacterial Agents Inside the Dental Implant
Fixture
Authors: Dizaj Solmaz Maleki , Memar Mohammad Yousef , Mosayebzadeh Amin , Ghavimi Mohammad Ali 
Published: March 2023

Introduction:
Titanium-based implants are widely used due to their good biocompatibility
and high corrosion resistance. Infections after implant placement are the main reason for the failure of
implant treatment. Some recent studies have also shown that microbial contamination can occur at the
implant-abutment level in implants with healthy or diseased surrounding tissue. The purpose of this
study is to investigate the antibacterial effect of slow-release nanoparticles of polylactic co-glycolic acid
(PLGA) loaded with chlorhexidine (CHX) inside the implant fixture.

Materials and Methods:
Thirty-six implants in three groups were examined in the bacterial culture environment.
In the first group, PLGA/CHX nanoparticles; in the second group, the negative control
group (distilled water) and in the third group, the positive control groups (chlorhexidine) were used. The
bacterial suspensions, including Escherichia coli ATCC: 25922, Staphylococcus aureus ATCC: 6538
and Enterococcus faecalis ATCC: 29212 were used to investigate the antimicrobial effect of the prepared
nanoparticles.

Results:
The results showed that the use of PLGA/CHX nanoparticles significantly inhibited the growth
of all three bacteria. Nanoparticles loaded with chlorhexidine had a significant decrease in the growth
rate of all three bacteria compared to chlorhexidine and water. The lowest bacterial growth rate was observed
in the Enterococcus faecalis/PLGA nanoparticles group, and the highest bacterial growth rate
was observed in the Staphylococcus aureus/H2O group.

Conclusion:
The current study showed that the use of PLGA/CHX nanoparticles could significantly inhibit
the growth of all three bacteria. Of course, the current study was conducted in vitro, and to obtain
clinical results, we need to conduct a study on human samples. In addition, the results of this study
showed that the chemical antimicrobial materials could be used in low concentrations and in a sustained-
released manner in cases of dealing with bacterial infections, which can lead to better and targeted
performance as well as reduce possible side effects.
The Effects of Exergaming on Attention in Children With Attention Deficit/Hyperactivity Disorder: Randomized Controlled Trial
Authors: Ji HongQing , Wu Shanshan , Won Junyeon , Weng Shiyang , Lee Sujin , Seo Sangmin , Park Jung-Jun 
Published: March 2023

BackgroundDespite growing evidence showing the effects of exercise and cognitive trainings on enhancing attention, little is known about the combined effects of exergame on attention in children with attention deficit/hyperactivity disorder (ADHD). Exergame, a form of exercise using a video game, has both cognitive stimulation and physical activity components and has been shown to improve cognitive function in children.ObjectiveThe purpose of this study was to investigate the effect of exergaming on attention and to compare the effect induced by exergaming with the effect of aerobic exercise on attention in children with ADHD.MethodsIn all, 30 children with ADHD, aged 8-12 years, were randomly divided into an exergaming group (EXG; n=16) or a bicycle exercise group (BEG; n=14). Before and after the 4-week intervention, the Frankfurter Aufmerksamkeits-Inventar (FAIR; Frankfurt Attention Inventory) test was administrated, and event-related potentials during the Go/No-go task was measured to assess attention.ResultsAfter intervention, both the EXG and BEG had significantly increased selective attention and continuous attention (all P<.001), as well as self-control on the FAIR test (EXG: P=.02 and BEG: P=.005). Similarly, both the EXG and BEG had significantly reduced response time on the Go/No-go test (all P<.001). For the Go response, the N2 amplitude (frontocentral maximal negativity) was significantly increased in Fz (midfrontal line) in the EXG (P=.003) but was not changed in the BEG (P=.97). Importantly, the N2 amplitude in Fz was significantly greater in the EXG compared to the BEG (Go: P=.001 and No-go: P=.008).ConclusionsExergaming has the comparable effects to bicycle exercise to enhance attention in children with ADHD, suggesting that exergaming can be used as an alternative treatment for children with ADHD.Trial RegistrationClinical Research Information Service KCT0008239; https://tinyurl.com/57e4jtnb
The Relationship Between Health Literacy, Knowledge, Fear, and COVID-19 Prevention Behavior in Different Age Groups: Cross-sectional Web-Based Study
Authors: Ishizuka-Inoue Mami , Shimoura Kanako , Nagai-Tanima Momoko , Aoyama Tomoki 
Published: March 2023

Background
COVID-19 prevention behaviors have become part of our lives, and they have been reported to be associated with health literacy, knowledge, and fear. However, the COVID-19 pandemic may be characterized by different situations in each age group. Since the severity of the infection and the means of accessing information differ by age group, the relationship between health literacy, knowledge, and fear may differ. Thus, factors that promote preventive behavior may differ by age group. Clarifying the factors related to prevention behaviors by age may help us consider age-appropriate promotion.

Objective
This study aims to examine the association between COVID-19 prevention behaviors and health literacy, COVID-19 knowledge, and fear of COVID-19 by age group.

Methods
A cross-sectional study was conducted among 512 participants aged 20-69 years, recruited from a web-based sample from November 1 to November 5, 2021. A web-based self-administered questionnaire was used to obtain the participants’ characteristics, COVID-19 prevention behaviors, health literacy, COVID-19 knowledge, and fear of COVID-19. The Kruskal-Wallis rank sum test was used to compare the scores of each item for each age group. The relationships among COVID-19 prevention behaviors, health literacy, COVID-19 knowledge, and fear of COVID-19 were analyzed using the Spearman rank correlation analysis. Additionally, multiple regression analysis was conducted with COVID-19 prevention behaviors as dependent variables; health literacy, COVID-19 knowledge, and fear of COVID-19 as independent variables; and sex and age as adjustment variables.

Results
For all participants, correlation and multiple regression analyses revealed that prevention behaviors were significantly related to health literacy, COVID-19 knowledge, and fear of COVID-19 (P<.001). Additionally, correlation analysis revealed that fear of COVID-19 was significantly negatively correlated with COVID-19 knowledge (P<.001). There was also a significant positive correlation between health literacy and COVID-19 knowledge (P<.001). Furthermore, analysis by age revealed that the factors associated with prevention behaviors differed by age group. In the age groups 20-29, 30-39, and 40-49 years, multiple factors, including health literacy, influenced COVID-19 prevention behaviors, whereas in the age groups 50-59 and 60-69 years, only fear of COVID-19 had an impact.

Conclusions
The results of this study revealed that the factors associated with prevention behaviors differ by age. Age-specific approaches should be considered to prevent infection.
Efficacy of an mHealth Behavior Change Intervention for Promoting Physical Activity in the Workplace: Randomized Controlled Trial
Authors: Alshagrawi Salah , Abidi Syed Taha 
Published: March 2023

Background
Insufficient physical activity (PA) is a well-established risk factor for several noncommunicable diseases such as cardiovascular diseases, cancer, diabetes, depression, and dementia. The World Health Organization (WHO) advises that individuals engage in 150 minutes of moderate PA per week or 75 minutes of intense PA per week. According to the WHO’s latest report, 23% of adults fail to meet the minimum recommended level of PA. The percentage was even higher in a recent global study that showed 27% of adults were insufficiently active and reported a 5% increase in the prevalence trend of insufficient PA between 2001 and 2016. The study also showed the rate of insufficient PA among countries varied significantly. For instance, it was estimated that 40% were insufficiently active in the United States, and the percentage was even higher in Saudi Arabia (more than 50%). Governments are actively developing policies and methods to successfully establish a PA-inducing environment that encourages a healthy lifestyle in order to address the global steady decline in PA.

Objective
The purpose of this study was to determine the effectiveness of mobile health (mHealth) interventions, particularly SMS text messaging interventions, to improve PA and decrease BMI in healthy adults in the workplace.

Methods
In this parallel, 2-arm randomized controlled trial, healthy adults (N=327) were randomized to receive an mHealth intervention (tailored text messages combined with self-monitoring (intervention; n=166) or no intervention (control; n=161). Adults who were fully employed in an academic institution and had limited PA during working hours were recruited for the study. Outcomes, such as PA and BMI, were assessed at baseline and 3 months later.

Results
Results showed significant improvement in PA levels (weekly step counts) in the intervention group (β=1097, 95% CI 922-1272, P<.001). There was also a significant reduction in BMI (β=0.60, 95% CI 0.50-0.69, P<.001).

Conclusions
Combining tailored text messages and self-monitoring interventions to improve PA and lower BMI was significantly effective and has the potential to leverage current methods to improve wellness among the public.