bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repetitive and compulsive behavior after Early-Life-Pain in mice
Authors: Vogel Alexandra , Ueberbach Timo , Wilken-Schmitz Annett , Hahnefeld Lisa , Franck Luisa , Weyer Marc-Philipp , Jungenitz Tassilo , Schmid Tobias , Buchmann Giulia , Freudenberg Florian , Brandes Ralf P. , Gurke Robert , Schwarzacher Stephan W. , Geisslinger Gerd , Mittmann Thomas , Tegeder Irmgard 
Published: February 2023

Abstract
Pain in early life may affect cortical development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of "early-life-pain" (ELP) using mice with transgenic expression of channelrhodopsin-2 (ChR2) under control of the Advillin (Avil) promoter, which drives expression of ChR2 in peripheral somatosensory neurons. Avil-ChR2 (Cre+) and ChR2-flfl control mice were exposed to blue light in a chamber once daily from P1-P5 together with their Cre-negative mother. ELP caused cortical hyperexcitability at P8-9 as assessed via multi-electrode array recordings that coincided with reduced expression of synaptic genes (RNAseq) including Grin2b, neurexins, piccolo and voltage gated calcium and sodium channels, suggesting activity-dependent synaptic pruning. Young adult (8-16 wks) Avil-ChR2 mice presented with nociceptive hypersensitivity upon heat or mechanical stimulation, which did not resolve up until one year of age. The persistent "pain" phenotype was reflected by capsaicin hypersensitivity in primary sensory neurons of aged mice (1 year) as assessed by calcium imaging. Adult Avil-ChR2 mice behaved like controls in maze tests of anxiety, social interaction and spatial memory but IntelliCage behavioral studies revealed repetitive nosepokes and corner visits and compulsive lickings. Compulsiveness at the behavioral level was associated with a reduction of sphingomyelin species in brain and plasma lipidomic studies pointing to alterations of sphingolipid metabolisms, which have been previously described in the context of addiction and psychiatric diseases. Hence, ELP may predispose to chronic pain and compulsive psychopathology.
The burden of Ischemic Heart Disease and the Epidemiologic Transition in the Eastern Mediterranean Region: 1990-2019
Authors: Sadeghi Masoumeh , Jamalian Marjan , Mehrabani-Zeinabad Kamran , Turk-Adawi Karam , Kopec Jacek , AlMahmeed Wael , Rahim Hanan Abdul F. , Farhan Hasan Ali , Anwar Wagida , Manla Yosef , Fadhil Ibtihal , Lui Michelle , Roohafza Hamidreza , Islam Sheikh Mohammed Shariful , Sulaiman Kadhim , Bazargani Nooshin , Saade George , Hassen Nejat , Alandejani Amani , Abdin Amr , Alhabib Khalid F , Bokhari Saira , Roth Gregory A , Johnson Catherine , Stark Benjamin , Sarrafzadegan Nizal , Mokdad Ali H. 
Published: February 2023

Abstract
Introduction

The purpose of this study is to investigate the trends of the burden of ischemic heart disease (IHD) in the Eastern Mediterranean Region (EMR) countries from 1990 to 2019.

Method

Prevalence, disability-adjusted life years (DALYs), death, DALYs attribution risk factors, healthcare access and quality index (HAQ), and universal health care (UHC) were extracted from the database of the Global Burden of Disease study (GBD) for the EMR countries. Data stratification is based on the social demographic index (SDI). Cardiac rehabilitation data was obtained from the International Council of Cardiovascular Prevention and Rehabilitation (ICCPR) and other information was e obtained by an advanced search of individualized countries’ data.

Result

IHD age-standardized prevalence increased from 4.96% to 5.31% in the EMR from 1990-2019 while it decreased at the global level. In the EMR, the trend of age-standardized IHD death and DALYs rates decreased by 11.39% and 15.36% between 1990 and 2019 respectively, however, both rates were higher than the global rates. The burden of IHD in males was higher than females.
The highest decrease of IHD age-standardized prevalence, death and DALYs rate in the EMR countries occurred in Bahrain (-3.72%, -64.95%and-69.08%, respectively). However, the most increase of prevalence happened in Oman with a change of 14.40% and for death and DALY rates was in Pakistan (29.62% and 31.93%, respectively) in the studied period.
The top three attributed risk factor to IHD DALYs in the EMR in 2019 were high systolic blood pressure, high low-density lipoprotein cholesterol, and particular matter pollution. The 29-year trend of an attributed risk factor to IHD DALYs in the EMR (1990-2019) showed that the two factors of high fasting plasma glucose (64.03%) and high BMI (23.39%) had an increasing trend, respectively.

Conclusion

Our results showed an increased trend of the prevalence of IHD in the EMR that requires well planned prevention and treatment strategies. Developing and implementing programs to address the risk factors through health promotion and education, preventive programs, and medical care should be a priority for countries in this region.
Eco-friendly one-step synthesis of highly functionalized-spirooxindole-pyranopyrazoles and their in-vitro anticancer studies
Authors: Asif Mohd , Aqil Farrukh , Almalki Amani salem , Alasmary Fatmah Ali , Khan Abdul Rahman , Nasibullah Malik 
Published: February 2023

Abstract
Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines. Compound 5c showed 43.19% and 21.18% growth inhibition at 10 µM for HOP-92 and UO-31 cell lines, respectively, while compound 5g showed 82.02% growth inhibition for the KM12 cell line at the same concentration. Therefore, the compound 5g could be further derivatized as a futuristic lead molecule for colorectal cancer.
High-performance Supercapacitors Enabled by N/S Dual-doped Porous Carbon and DMO-regulated Electrolyte
Authors: Zhao jingyuan , Wang Meng , Jiang Chaojie , Liu Zhenyan , Lin Jiayu , Meng Xue , Zhang Pengfei , Deng Kuilin 
Published: February 2023

Abstract
The pristine carbon materials and traditional electrolytes can not fully meet the increasing practical demand for the high-performance of supercapacitors. Herein, a petal-like multicyclic polycondensate precursor (PCDP) was first prepared by Knoevenagel reaction and amine/aldehyde condensation between 3-aminorhodanine and p-phthalaldehyde. The subsequent activation of PCDP by KOH and final carbonization at different temperatures (600–900 ℃) was performed to get N/S-dual doped porous carbon (N/S-DDPCs) as electrode materials. For N/S-DDPC8 carbonized at 800 ℃, the highest specific surface area was measured as 2047 m2 g− 1, with a large number of interconnected microporous and mesoporous structures and the higher N and S contents of 3.57% and 2.31%, respectively. In addition, Zn(CF3SO3)2 aqueous electrolyte regulated by dimethyl oxalate (DMO) was fabricated in order to further enhance and stabilize the electrochemical performance for N/S-DDPCs. In contrast to the traditional Zn(CF3SO3)2 electrolyte, the energy density and power density of N/S-DDPC8 in DMO-regulated Zn(CF3SO3)2 electrolyte was significantly increased to 36.4 Wh kg− 1 from 11.7 Wh kg− 1 and to 642 W kg− 1 from 250 W kg− 1 at a current density of 0.5 A g− 1, respectively. Most excitedly, N/S-DDPC8-DMO-D can maintain 100% specific capacitance even after 10000 cycles, showing the superhigh electrochemical stability. In brief, N/S-dual doped porous N/S-DDPCs and DMO-regulated electrolyte prepared in this study provides a useful reference for the synergistically enhancing the electrochemical performance for the supercapacitors.
Model test study of oil and gas pipeline crossing landslide
Authors: Wang Yuan Dong 
Published: February 2023

Abstract
As an ultra-long linear project, oil and gas pipelines are vulnerable to landslide disasters, which poses a serious threat to the normal operation of pipelines and the safety of national property. Taking shallow soil and lateral landslide, which are the most common in pipeline landslide accidents, as the main research objects, large-scale model tests were carried out. Different slopes and different landslide displacement conditions were controlled and changed by model box loading device, and the stress response rule and deformation failure characteristics of pipeline under the action of lateral landslide were studied. The research results show that the pipeline buckling occurs locally in the midspan, and the whole pipeline is in the form of beam symmetric bending failure. When the pipeline is in the elastic and elastic-plastic stage, the test value of the pipeline axial strain is basically consistent with the results of numerical simulation (PSI model and solid element model), and the test value of the pipeline buckling failure is significantly greater than the numerical simulation results. The research results have important guiding significance for the laying and prevention of oil and gas pipelines in mountainous areas.
The efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study
Authors: Li Peishun , Man Qirong , Bai Yunling , Xing Chao , Yuan Qianqian , Yang Wanying , Ren Yanchen , Zhang Kaixian 
Published: February 2023

Abstract
Purpose
To evaluate the efficacy and safety of computed tomography (CT)-guided 125I seed implantation by coplanar template for vertebral metastases after failure of external beam radiation therapy. We also want to compare the dosimetry of 3D printed coplanar template-assisted interstitial 125I brachytherapy preoperative and postoperative, and to explore the accuracy of this technology.
Material and methods
We retrospectively collected and analyzedthe results of 56 patients with vertebral metastases after failure of external beam radiation therapy, who underwent interstitial 125I brachytherapy as a salvage treatment with a CT-guided coplanar template-assisted technique from January 2015 to January 2017.
Results
The NRS score for worst pain was 6.1 ± 1.1 before 125I seed implantation. The mean posto-perative NRS score decreased significantly at T4w (3.5 ± 0.9, p < 0.01), T8w (2.1 ± 0.9, p < 0.01), T12w (1.5 ± 0.7, p < 0.01) and T6m (1.2 ± 0.6, p < 0.01) respectively. There was no significant difference in scores among T0, T24h (P = 0.10) and T1w (P = 0.09). The local control rates after 3, 6, 9 and 12 months were 100% (58/58), 92.5% (49/53), 90.2% (46/51), and 85.1% (40/47), respectively. By performing paired t-test analysis, there were no significant differences in D90, D100, V90, V100, V150, V200, GTV volume, CI, EI and HI between preoperative and postoperative(p༞0.05). Postoperative D90 was an independent influencing factor of local control time (HR: 1.047, 95% CI: 0.998–1.098, p = 0.043). The optimal Cut-off value of postoperative D90 was 130 Gy.
Conclusions
Interstitial 125I seed implantation can be used as a salvage treatment forpatients with vertebral metastases after failure of external beam radiation therapy. With the auxiliary function of 3D printed coplanar template, the main dosimetry parameters verified after the operation can meet the requirements of the preoperative plan with good treatment accuracy.
Ovarian clear cell carcinoma with or without endometriosis origin in a single institution cohort
Authors: Sun Mingming , Jiang Wei 
Published: February 2023

Abstract
Background
As ovarian clear cell carcinoma (OCCC) has distinct clinical features, biology, genetic characteristics and mechanisms of pathogenesis, and whether the origin of endometriosis or not affects the prognosis of OCCC remains controversial.
Methods
We retrospectively collected medical records and follow-up data of patients with OCCC treated at the Obstetrics and Gynecology Hospital of Fudan University from January 2009 to December 2019. Further, we divided patients into 2 groups. Group 1: non-endometriosis origin; Group 2: endometriosis origin. Clinicopathological characteristics and survival outcomes were compared between the 2 groups.
Results
A total of one hundred and twenty-five patients with ovarian clear cell carcinoma were identified and included. In the overall patients’ population, the 5-year overall survival was 84.8%, the mean overall survival was 85.9 months. The results of the stratified analysis showed that early stage (FIGO stage I/II) OCCC had a good prognosis. The results of univariate analyses indicated that a statistically significant relationship between overall survival (OS) and FIGO stage, lymph node metastasis, peritoneum metastasis, chemotherapy administration methods, Chinese herbal treatment, molecular target therapy. As for progression-free survival (PFS), a significant relationship between PFS and child-bearing history, largest residual tumor size, FIGO stage, tumor maximum diameter, lymph node metastasis was found, respectively. FIGO stage and lymph node metastasis are common poor prognostic factors affecting OS and PFS. The multivariate regression analysis revealed that FIGO stage (p = 0.028; HR, 1.944; 95% CI, 1.073–3.52) and treatment by Chinese herbs (p = 0.018; HR, 0.141; 95% CI, 0.028–0.716) were identified as influencing factors with regard to survival. The presence or absence of lymphadenectomy did not affect OS of 125 OCCC patients (p = 0.851; HR, 0.825; 95% CI, 0.111–6.153).
Mean curvature flow solitons from the symmetry group viewpoint
Authors: Han Xu , Hou Zhonghua 
Published: February 2023

Abstract
The symmetry group of the mean curvature flow in general ambient Riemannian manifolds is determined, based on which we define generalized solitons to the mean curvatureflow. We also provide examples of homothetic solitons in non-Euclidean surfaces and prove that all the affine solutions to the mean curvature flow are self-similar solutions.
Geochemistry and P-T pseudosection modelling of two-pyroxene mafic granulite from Sonapahar, Shillong Meghalaya Gneissic Complex (SMGC), India: Implication for tectono-metamorphic evolution
Authors: Mahanta B. , Prakash D. , Kumar M. , Singh S. , Pandey R. K. , Singh C. K. 
Published: February 2023

Abstract
Granulites exposed in high-grade regional metamorphic belts and exhumed as xenoliths in basaltic pipes are considered as window into the deep crust thus play a key role in constraining models of crustal processes and evolution. Understanding granulites not only helps us place limits on the nature and composition of the lower crust in the existing continents, but it also sheds light on the crucial tectonic and chemical processes that lead to the accretion and eventual stabilisation of present crust dynamics, which in turn endorse continental growth. The study area, Sonapahar situated in the central portion of Shillong Meghalaya Gneissic Complex (SMGC) contain rich assemblage of different metamorphic rocks ranging from amphibolite to granulites. Unlike pelitic granulite, which receive much attention throughout the world, this work primarily focus in constraining the metamorphic evolution of two-pyroxene mafic granulite, which lack proper documentation hereto. Here we construct for the first time the P-T evolution of two-pyroxene mafic granulite from the Sonapahar, SMGC. Metamorphic P-T conditions estimated for the mafic granulite using conventional thermobarometer and winTWQ shows temperature in excess of 800 OC and pressure of about 9 kbars, stand for high temperature granulite facies metamorphism. The metamorphic evolution path continuing from prograde, peak to post-peak is obtained by constructing P-T pseudosection using Perple_X software in NCKFMASHTO system. Result suggest a clockwise P-T evolution path, thus signify isothermal decompression and indicate rapid upliftment prior to cooling of the tectonically thickened crust. Geochemical study of trace and REE, further suggest protolith is of tholeiite basalt in nature that is derive from hybrid (VAB+MORB) tectonic setting.
Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq
Authors: Kim Hugo , Saikia Junmi , Monte Katlyn , Ha Eunmi , Romaus-Sanjurjo Daniel , Sanchez Joshua , Moore Andrea , Hernaiz-Llorens Marc , Chavez-Martinez Carmine , Agba Chimuanya , Li Haoyue , Lusk Daniel , Cervantes Kayla , Zheng Binhai 
Published: February 2023

Abstract
The corticospinal tract (CST) is clinically important for the recovery of motor functions after spinal cord injury. Despite substantial progress in understanding the biology of axon regeneration in the central nervous system (CNS), our ability to promote CST regeneration remains limited. Even with molecular interventions, only a small proportion of CST axons regenerate1. Here we investigate this heterogeneity in the regenerative ability of corticospinal neurons following PTEN and SOCS3 deletion with patch-based single cell RNA sequencing (scRNA-Seq)2,3, which enables deep sequencing of rare regenerating neurons. Bioinformatic analyses highlighted the importance of antioxidant response and mitochondrial biogenesis along with protein translation. Conditional gene deletion validated a role for NFE2L2 (or NRF2), a master regulator of antioxidant response, in CST regeneration. Applying Garnett4, a supervised classification method, to our dataset gave rise to a Regenerating Classifier (RC), which, when applied to published scRNA-Seq data, generates cell type- and developmental stage-appropriate classifications. While embryonic brain, adult dorsal root ganglion and serotonergic neurons are classified as Regenerators, most neurons from adult brain and spinal cord are classified as Non-regenerators. Adult CNS neurons partially revert to a regenerative state soon after injury, which is accelerated by molecular interventions. Our data indicate the existence of universal transcriptomic signatures underlying the regenerative abilities of vastly different neuronal populations, and further illustrate that deep sequencing of only hundreds of phenotypically identified CST neurons has the power to reveal new insights into their regenerative biology.
Genotype-Environment Interaction in ADHD: Genetic Predisposition Determines the Extent to Which Environmental Influences Explain Variability in the Symptom Dimensions Hyperactivity and Inattention
Authors: Schwabe Inga , Jović Miljan , Rimfeld Kaili , Allegrini Andrea G. , Berg Stephanie M. van den 
Published: February 2023

Abstract
Although earlier research has shown that individual differences on the spectrum of the attention deficit hyperactivity disorder (ADHD) are highly heritable, emerging evidence suggests that symptoms are associated with complex interactions between genes and environmental influences. This study investigated whether a genetic predisposition for the symptom dimensions hyperactivity and inattention determines the extent to which unique-environmental influences explain variability in these symptoms. To this purpose, we analyzed item-level scores of 2168 twin pairs who completed both the Strengths and Difficulties Questionnaire (SDQ) and the Strength and Weaknesses of ADHD Symptoms and Normal Behavior (SWAN) questionnaire. To maximize the psychometric information to measure ADHD symptoms, psychometric analyses were performed to investigate whether the items from the two questionnaires can be combined to form two longer subscales. In the estimation of genotype-environment interaction, we corrected for error variance heterogeneity in the measurement of ADHD symptoms through the application of item response theory (IRT) measurement models. Results indicated that unique-environmental influences were more important in creating individual differences in both hyperactivity and inattention for twins with a genetic predisposition for these symptoms than for twins without such a predisposition.
A note on equality-constrained continuous optimization within the quantum approximate optimization framework
Authors: Zhang Yabin , Stokes James , Gorisch David , Jayakumar Paramsothy , Veerapaneni Shravan 
Published: February 2023

Abstract
The possibility of controlling the evolution of a quantum wavepacket to achieve optimization of a high-dimensional continuous function has been proposed and subsequently experimentally demonstrated in optical quantum hardware. In this short note we clarify how existing proposals for constrained continuous optimization are subject to instabilities which result from a Hamiltonian whose spectrum is unbounded in both directions. In addition we offer an alternative algorithm which is free from instabilities with potentially improved shot efficiency.
Data mining-based analysis of the application traits and dispensing patterns of borneol containing patented Chinese medicines
Authors: Zhong Ye , Qi Yue , Jiang Zhilan , Hu Yongsheng , Wu Chunxing , Wang Bolong , Zhang Xiao , Wang Zetian 
Published: February 2023

Abstract
Background: To give references for the clinical application of borneols and innovative medication development, as well as to reveal the dose pattern of patent Chinese medicines that contain borneols.
Methods: The database of proprietary Chinese medicines on Drugwise.com was searched for internal and external prescriptions that contained borneols and the diseases they treat. The frequency, taste, prescription, and association rules of the drugs were then analyzed using Microsoft Office Excel 2019 and SPSS Modeler 18.0 software, and the association rule display graphs were created using Origin21.0 software.
Results: The Chinese medicines with the highest frequency of borneol dispensing in
internal prescriptions were Niuhuang, Licorice, Zhu Sha, Musk, and Scutellaria, etc. The main treatment categories were primarily brain diseases and heart diseases, etc. There were 528 prescriptions for internal Chinese patent medicines containing borneols and 387 prescriptions for external Chinese patent medicines included. Menthol, camphor, frankincense, angelica, safflower, and other Chinese herbal remedies were used in combination with borneols more frequently in external prescriptions. Body ailments like paralysis, tumors, sores, ulcers, etc. were the primary treatment categories.
Conclusion: Both the internal and exterior borneol prescriptions have a cold and warm character, as well as a pungent and bitter flavor. The external prescriptions are mostly classified into the liver, heart, and spleen meridians, and are frequently combined with heat-clearing and blood-activating drugs to treat rheumatic paralysis and sores and ulcers. The internal prescriptions are mostly classified into the heart, liver, and lung meridians. They are often combined with sedative and detoxifying drugs to treat stroke, pediatric shock, and angina pectoris.
Empirical Green’s Function Simulations Toward Site-Specific Ground Motion Prediction for Kopili Fault of NER India
Authors: Bora Nilutpal , Das Sandip 
Published: February 2023

Abstract
We report new findings for producing broad-band ground motion time histories (1–19 Hz) of a future earthquake in a sedimentary basin based on the application of extended rupture modelling together with the use of empirical Green's functions (EGFs). This technique is used to model a MW 6.0 earthquake in Kopili fault zone (KFZ) north-eastern India (NER). We ran simulations for a sediment site (VS30 = 360 to 760 m/s) and a rock site (VS30 = 760 to 1500 m/s) to obtain the ground motion, which are then compared with a number of ground motion prediction equations (GMPEs). These GMPEs agree with the simulated ground motion amplitude, confirming that once we have precise source terms, the artificial ground-motions generated from earthquake scenarios of a specific site may be employed for seismic design safety in that given site. This work may open the door to additional in-depth, site-specific research in this area.