bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteristik Fisikokimia, Mikrobiologi, dan Uji Pasar Yogurt Smoothies Rosela Stroberi pada Usia Remaja dan Dewasa di Bogor
Authors: Berutu Putra Jahtra , Arief Irma Isnafia , Soenarno Mochammad Sriduresta , Dekriyatna Lucya Cyrilla Eko Nugrohowati Supriyadi 
Published: September 2023

Yogurt is a dairy product that is processed into a fermented drink using lactic acid bacteria. Smoothies are drinks made from fruit or vegetables containing milk, yogurt, or honey. Strawberry Rosella Yogurt Smoothie is yogurt that has been processed by reducing the water content and adding rosella flower extract and strawberry jam. Before being marketed, these products need to be tested for safety and market opportunities. This study aims to analyze the physicochemical characteristics, microbiology, and market tests of strawberry rosella yogurt smoothies in adolescents and adults in Bogor. The physicochemical characteristics tested included pH, water activity (aw), viscosity, and total titrated acid. The microbiological parameters tested were total lactic acid bacteria and Salmonella sp. The market parameters tested include analysis of consumer perceptions and preferences and their correlation with yogurt consumption patterns. The market test was carried out using 100 respondents consisting of 50 students from SMAN 1 Bogor and 50 students from IPB University. The results showed that the physical properties (pH, water activity, viscosity, and total lactic acid) fulfilled the SNI yogurt quality requirements. The chemical properties or nutritional content and microbiological properties of yoghurt smoothies have met the requirements for yoghurt quality standards based on SNI. The results showed that respondents had good perceptions and preferences on the attributes of smoothie yogurt. Consumer preferences regarding the appearance of the packaging in general, color, ingredient content, packaging information, and appearance of the contents of the yogurt are generally positively correlated with the price range of yogurt that consumers buy. Strawberry Rosella Yoghurt Smoothie is safe for consumption and can be marketed. Keywords: consumer perception, consumer preferences, microbiology, physicochemistry, yogurt smoothies
Keamanan Mikrobiologis Air Minum Isi Ulang dan Perubahannya Selama Penyimpanan
Authors: Tasya Fitri Yunada  , Winiati Pudji Rahayu  , Dian Herawati  
Published: September 2023

Indonesians use refilled drinking water which can be obtained at depots because of practical and affordable reasons. Low levels of sanitation and hygiene and storage of refilled drinking water for an extended period can lead to the possibility of the growth of indicator and pathogenic microorganisms such as Coliform and Escherichia coli (E. coli). This study aims to evaluate the application of drinking water refilling stations (DWRS) sanitary hygiene, microbiological quality and safety of refilled drinking water and its changes during storage. Samples of refilled drinking water were taken from two DWRSs for each region in five areas of DKI Jakarta including West, East, South, North, and Central Jakarta. The treatments in this study were refilled drinking water storage in gallons of closed and open-closed conditions at room temperature (28 + 2°C) for 0, 7, and 14 days. The results of observations showed that 30% (n=30) of depots complied with hygiene sanitation standards according to Permenkes RI No. 43 of 2014 (>70%). The analysis results showed that refilled drinking water at 0 days of storage, 100% met the TPC (5 Log CFU/mL), 20% met the total Coliform standard (0 Log CFU/mL), and 80% met the E. coli standard (0 Log CFU/mL) according to Permenkes RI No. 492 of 2010. Storage times of 0, 7, and 14 days of refilled drinking water had a significant effect on TPC and total Coliform (P < 0.05), but had no significant effect on E. coli (P > 0.05) in gallons with closed and open-closed conditions.

Keywords: Coliform, DWRS, E. coli, refilled drinking water
Sifat Fisika dan Mekanika Kayu Acacia aulacocarpa dari KHDTK Wanagama
Authors: Gaol Nur Indah Lumban , Hidayati Fanny , Nugroho Widyanto Dwi , Praptoyo Harry , Karyanto Oka , Marsoem Sri Nugroho 
Published: September 2023

This study aims to determinethe physical properties and mechanical properties at axial (base, middle, and top) and radial (near the pith, middle, and near the bark) positions, as well as the relationship between the specific gravity and mechanical properties of Acacia aulacocarpa wood. Three 27-year-old trees planted at KHDTK Wanagama wereused. Wood physical and mechanical propertieswere tested per British Standard 373:1957. The statistical analysis used was a two-way ANOVA and a follow-up test of Tukey HSD. The results showed that the average moisture content was 98.95%; the green and air-dry sepesific gravity were 0.58 and 0.61. Radial, tangential, and longitudinal shrinkage from green to oven-dry conditions (total shrinkage) were 2.02%, 5.09%, and 0.33%. The tangential/radial (T/R) ratio was 2.80%. The static bending strength of stress at proportion limit, MoE, and MoR were 498.13 kg/cm2, 116.16x1000 kg/cm2, and 1043.68 kg/cm2, respectively. The compressive strength parallel to the grain and perpendicular to the grain were 596.05 kg/cm2 and 227.25 kg/cm2, respectively. The results of the variance analysis showed that the radial position factor has a significant effect on green moisture content, green and air-dry specificgravity, total radial shrinkage, T/R ratio, static bending strength at stress of proportion limit, MoE, MoR, compressive strength parallel to the grain, and compressive strength perpendicular to the grain. However, the axial position factor did not show any significant differences in the physical and mechanical properties of the wood. Furthermore, air-dry specific gravity has a significant moderate to high positive correlation with all mechanical properties.
Keywords: Acacia aulacocarpa, physical properties, mechanical properties, axial position, radial position
Pengkayaan CaCl2 pada Nutrisi Hidroponik untuk Meningkatkan Hasil Tanaman Kailan (Brassica oleraceae L.)
Authors: Abror M. , Miftakhurrohmat Agus , Arifin Saiful 
Published: September 2023

One highly sought-after vegetable is Kalian (Brassica oleraceae L.), valued for its exceptional nutritional content. The cultivation of kalian demands specialized attention. Hydroponic cultivation utilizing Calcium Chloride plays a pivotal role in fostering robust plant growth and resilience, particularly in urban settings. Calcium serves a multifaceted role: safeguarding against pests, enhancing fruit quality, and functioning as an antioxidant during storage. This research was conducted between October 2022 and February 2023, employing a single-factor Randomized Block Design (RBD) that was replicated three times. The study encompassed the following treatments: (i) Control with 0 ppm CaCl2, (ii) 550 ppm CaCl2 (P1), (iii) 650 ppm CaCl2 (P2), and (iv) 750 ppm CaCl2 (P3). The observed parameters encompassed plant height, leaf count, leaf area, fresh weight, and dry weight. The data underwent analysis via analysis of variance (ANOVA), followed by the Honest Significant Difference (HSD) test at the 5% significance level. The outcomes of the study unveiled substantial and statistically significant responses at the 7th, 14th, 21st, and 28th days after planting (HST) concerning the leaf count and wet weight variables. However, no statistically significant response was observed in relation to root length and leaf area measurements.

Keywords: CaCl2, kailan, hydroponics, Ab Mix nutrition
Chemical and Fatty Acids Composition of Yak Milk from Qinghai-Tibetan Plateau in Different Seasons
Authors: Hong-xin Jia , Mi-ya Su , Wen-liang Chen 
Published: September 2023

Background: Yak milk is the main source of dietary protein, fat and micronutrients for Qinghai-Tibetan Plateau residents. However, few studies have focused on the seasonal variation of nutritional components in natural grazing (without supplementary feeding) yak milk. Methods:Yaks living at high altitudes (average altitude of more than 4200 metre) were selected (summer, n=18; winter, n=18; spring, n=15) to analyzed seasonal influence on chemical and fatty acids composition of yak milk. Result: Results showed that the contents of fat, protein, lactose, non-fat milk solid, vitamin A and the main fatty acids (C6:0, C12:0, C14:0, C15:0, C16:0, C17:0, C20:0, cis-9 C16:1, cis-9 C18:1, trans-9 C18:1, LA, etc.) in winter yak milk were significantly different from those in summer and spring yak milk (p less than 0.05). This suggests that chemical and fatty acids composition of yak milk were influenced by seasons.
Teoría Habermasiana y Educación Rural Emancipadora:
Authors: Soler Rocha José Edilson 
Published: September 2023

Por ser la educación un término universal que alude a una condición necesaria para el desarrollo humano, esta se convierte en un reto para el gobierno, en especial cuando se habla de educación rural. No obstante, hay un desfase innegable entre el ser y el deber ser, que se concentra en la acción comunicativa (la interacción) de los niveles del gobierno, que ocasiona una acción instrumental (el trabajo) no encaminada hacia el desarrollo de una política pública educativa de lo rural y para lo rural.Con esta perspectiva, el lector encontrará un constructo teórico que aborda la educación rural emancipadora a través de la acción comunicativa según la teoría crítica habermasiana. El objetivo es comprender el mundo de la educación rural en Colombia considerando las cuatro acciones sociológicas propuestas por Habermas: la acción teleológica, regulada por normas, dramatúrgica y comunicativa.
Fontes, documentos e arquivos na fronteira entre Antropologia, História e outros saberes
Authors: Cardoso Antonio Alexandre Isidio , Tambascia Christiano Key , Nadai Larissa , Ariza Marília Bueno de Araújo , Alcântara Paulo Augusto Franco de 
Published: September 2023

Nas últimas décadas, muito tem se produzido sobre as relações, fricções e tensões entre os fazeres antropológicos e historiográficos. Tal atenção tem sido ainda mais evidente diante de indagações críticas sobre os regimes e usos de fontes, documentos e arquivos. Denominada muitas vezes por codinomes como “antropologia histórica” e/ou “história cultural”, as fronteiras que conformam Antropologia, História e sua articulação com outros saberes têm, por muitos de nós, sido intencionalmente transgredidas, borradas e esmaecidas. Este dossiê, “Fontes, documentos e arquivos na fronteira entre Antropologia, História e outros saberes” demonstra tais esforços de insubmissão e convergência a partir dos mais variados campos empíricos - documentos administrativos, “causos populares”, documentos acadêmicos, memórias orais, etc. Os artigos aqui reunidos e organizados, neste sentido, não só desafiam àquilo que restou registrado em fontes e arquivos, como também lançam luz aos esforços de produzir outros arquivos e/ou disputar as verdades neles contidas sobre um passado histórico a ser contestado e posto sob escrutínio.
Interprofessional Diagnostic Management Teams: A Scoping Review Protocol
Authors: Hansen Nicoline Lykke , Precht Helle , Larsen Palle , Noehr-Jensen Lene 
Published: September 2023

Abstract
Background: The diagnostic process has been a blind spot in relation to patient safety. A Danish evaluation of cases concerning treatment injuries from 2009 to 2018 shows that 14.5% (13,000 out of 90,000) of all settled cases are related to diagnostic errors. The report from 2019 points out the importance of incorporating teamwork in the diagnostic process. An American report from 2015 suggests implementing diagnostic management teams, including patients and their relatives, diagnosticians, and healthcare professionals who support the diagnostic process, as a way to limit diagnostic error and improve patient safety. The objective of this scoping review is to map and understand the extent and type of evidence in relation to interprofessional diagnostic management teams, providing diagnostic care in the healthcare system, in general, for adults and children with somatic conditions.
Methods: We will conduct this scoping review according to the PRISMA 2020 statement. We will systematically search five databases (EMBASE, PubMed, CINAHL, Academic Search Premier and SCOPUS) for papers published between 1985 and 2022 that describe the use of interprofessional diagnostic management teams. Two independent reviewers will screen titles/abstracts and full text articles based on whether they meet the inclusion criteria. The participants included will be adults and children seeking diagnostic care for a somatic condition. The concept studied will be interprofessional diagnostic management teams, and the context will be the diagnostic process in the healthcare system. Studies examining the diagnostic process in psychiatry, odontology or complementary medicine will be excluded. Any disagreement will be resolved by discussion and eventually by consulting a third reviewer. Data extraction will include study characteristics and findings.
Discussion: Despite the severity of the problem, this will be the first scoping review on interprofessional diagnostic management teams. This scoping review attempts to shed an important and needed light on the diagnostic process in relation to the improvement of patient safety.
Protocol registration: The project is registered at Open Science Framework (OSF) with ID: osf.io/kv2n6
Mechanism of feedforward Parkin activation by self-association
Authors: Lenka Dipti , Dahe Shakti , Antico Odetta , Sahoo Pritiranjan , Muqit Miratul M. K. , Kumar Atul 
Published: September 2023

Abstract

Loss of function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3-ligase activated by phosphorylation of its ubiquitin-like (Ubl) domain and ubiquitin by PINK1. Herein, we show a competitive binding mode of the phospho-Ubl and RING2 domains on the RING0 domain, which regulates Parkin activity. We show that phosphorylated Parkin can complex with unmodified Parkin, leading to the activation of autoinhibited Parkin in trans. Furthermore, we show that the activator element (ACT) of Parkin is required to maintain the enzyme’s kinetics, and the removal of ACT slows the enzyme catalysis. We also demonstrate that ACT can activate Parkin in trans but less efficiently than when present in the cis molecule. Furthermore, we have identified and characterized a new donor ubiquitin binding pocket that plays a crucial role in function. This study provides new molecular insights into Parkin activation which may aid the development of Parkin activators as a therapeutic strategy against Parkinson’s.
Infectious vaginitis among women seeking reproductive health services at a sexual and reproductive health facility in Kampala, Uganda
Authors: Mujuzi Huzaima , Siya Aggrey , Wambi Rogers 
Published: September 2023

Abstract
Background
Infectious vaginitis is one of the most prevalent conditions affecting women of reproductive age with significant clinical consequences. Bacterial vaginosis (BV), vulvo-vaginal candidiasis (VVC), and trichomoniasis (TV) are the main etiologies. Unfortunately, there is limited data on the prevalence and associated risk factors especially in sub-saharan Africa. This study, thus, determined the prevalence and risk factors of infectious vaginitis among women seeking reproductive health services at a Marie Stopes health facility in urban areas of Kampala, Uganda.
Methods
A cross-sectional study with 361 participants was conducted from July to October 2021. Data on risk factors and infection were collected via a structured questionnaire and laboratory analysis of vaginal swabs, respectively, with data analysis performed using Stata version 14.0.
Results
The ages of participants ranged from 18 to 49 years, with a mean age of 29.53 years. Overall, 58.45% were infected, of whom 33.24% had VVC, 24.93% had BV, and 0.28% had TV. Bivariate analysis, revealed that women with pruritus (COR: 3.057, 95% CI: 1.940–4.819), pregnancy (COR: 4.914, 95% CI: 1.248–19.36), antibiotic use (COR: 1.592, 95% CI: 1.016–2.494), douching (COR: 1.719, 95% CI: 1.079–2.740), and multiple partners (COR: 1.844, 95% CI: 1.079–2.904) were more likely to have VVC, whereas having higher education status (University; Vocational) (COR: 0.325, 95% CI: 0.134–00.890; COR: 0.345, 95% CI: 0.116–00.905) reduced the risk. On the other hand, women with a smelly discharge (COR: 1.796, 95% CI: 1.036–3.110), IUD use (COR: 1.868, 95% CI: 1.039–3.358), and antibiotic use (COR: 1.731, 95% CI: 1.066–2.811) were more likely to have BV. Multivariable analysis identified pruritus (AOR: 2.998, 95% CI: 1.757–5.115) as the only independent predictor for VVC.
Conclusion
Although the target site may not yield results that are generalizable to the entire urban areas of Kampala, results indicate high prevalence of infection among these women. The risk factors point to the need for health education, regular screening, and treatment for females of reproductive age group to reduce the prevalence of infection.
Venlafaxine induces psychiatric disorders due to upregulation of cerebral catechol-O-methyltransferase via the PI3K/AKT/mTOR pathway
Authors: Liu Li , Qian Liqiang , Yang Hanyu , Ye Qianli , Xu Zijun , Liu Yanlin , Wang Zehua , Wu Wenhan , Liu Xiaodong 
Published: September 2023

Abstract
Clinical use of venlafaxine often leads to several central nervous system adverse events, but its mechanisms are still unclear. We observed obvious impairments in locomotor and exploration activities during open-field and tail-suspension tests in venlafaxine-treated rats and mice, which indicated that venlafaxine could induce the anxiety-like behavior with co-morbid depressive-like behavior in experimental animals. Different from the accepted opinion that altered dopamine (DA) or 5-hydroxytryptamine (5-HT) levels could induce psychiatric disorders, venlafaxine treatment did not affect the levels of DA and 5-HT, but significantly decreased levels of 3,4-Dihydroxyphenylacetic acid (DOPAC) and increased levels of homovanillic acid (HVA). Catechol-O-methyltransferase (COMT) mediates the formation of HVA from DOPAC. Further investigation found that venlafaxine significantly upregulated the expression and activity of COMT, whilst decreasing levels of S-adenosylmethionine (SAM, a methyl-donor), histone H3 lysine 4 trimethylation (H3K4me3), and histone H3 lysine 27 trimethylation (H3K27me3) in the cortexes of rats and mice. Treatment of COMT inhibitor tolcapone or SAM attenuated venlafaxine-induced psychiatric disorders and decreases in cerebral SAM, H3K4me3, and H3K27me3 levels. In vitro, venlafaxine and mTOR activator MHY1485 also led to upregulations in COMT expression and decreases in levels of SAM, H3K4me3, and H3K27me3, whilst tolcapone and SAM attenuated these changes. Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, mammalian target of rapamycin (mTOR) inhibitor rapamycin, and silencing ribosomal protein 70 S6 kinase (P70S6K) or eIF4E-binding protein 1 (4EBP1) remarkably attenuated the induction of COMT by venlafaxine. Significantly increased phosphorylation levels of AKT, P70S6K, and 4EBP1 were also detected in the cortexes of venlafaxine-treated rats and mice. These results indicate that venlafaxine induces COMT expression via activating the PI3K/AKT/mTOR pathway, leading to decreases in levels of SAM, H3K4me3, and H3K27me3, which ultimately results in the occurrence of several psychiatric symptoms.
Serum heme oxygenase-1 as a prognostic biomarker in patients with acute exacerbation of interstitial lung disease
Authors: Tagami Yoichi , Hara Yu , Murohashi Kota , Nagasawa Ryo , Fujii Hiroaki , Izawa Ami , Yabe Aya , Saigusa Yusuke , Kobayashi Miyu , Shiida Masafumi , Hirata Momo , Otsu Yukiko , Watanabe Keisuke , Horita Nobuyuki , Kobayashi Nobuaki , Kaneko Takeshi 
Published: September 2023

Abstract
Serum heme oxygenase (HO)-1 level has been reported as a clinically reliable diagnostic biomarker for acute exacerbation (AE) of interstitial lung disease (ILD); however, its utility for predicting mortality among these patients is unclear. Serum HO-1 levels of patients newly diagnosed with AE of ILD were measured at the time of initiating steroid pulse therapy. The relationship between serum HO-1 and various other serum biomarkers, change in HRCT), and disease prognosis at 12 weeks after diagnosis of AE was evaluated in 51 patients with AE, of whom 17 (33%) had idiopathic pulmonary fibrosis (IPF). Serum HO-1 was higher in patients with AE of IPF than in patients with AE of other ILDs. Serum HO-1 levels were higher in patients who died within these 12 weeks than in survivors. Among age, sex, comorbidities, IPF diagnosis, HRCT findings, and blood biomarkers, serum HO-1 was a primary predictor of 12-week mortality. In 41 patients who underwent repeat HRCT, serum HO-1 was higher in patients with than in those without honeycomb progression. Serum HO-1 measurement could be useful for evaluating disease mortality and predicting subsequent fibrosis formation among patients with AE of ILDs.
Biomarkers of Catalase, Glutathione S-transferase and EROD in Echinometra mathaei exposed to PAHs in northern Persian Gulf
Authors: Badri Setareh , Jamili Shahla , Riazi Gholamhossein , Moradi Ali Mashinchian 
Published: September 2023

Abstract
The Persian Gulf is a semi-enclosed sea with special ecological conditions, where oil pollution average is higher than the minimum optimum level by the global marine environment. Echinoderms are one of the most important marine phyla of this ecosystem, which are more exposed to pollutions in sediments because they live on the bottom. Many biomarkers are able to identify the adverse effects of chemical environmental pollutants. The present study is endeavored to study the Catalase, Glutathione S-transferase and EROD response change of Echinometra mathaei collected from northern Persian Gulf. Sampling was carried out at T-wharf Khark, north Khark, Nai-Band, Shirino, Owli and Shaghab beach of Bushehr stations and the levels of enzymes were measured in the cold and warm seasons. The maximum and minimum Catalase activity among all stations and in both seasons were obtained in Shirino (1.95 µmol/min/mg protein) and Bushehr (0.98 µmol/min/mg protein). The highest and lowest enzyme activity levels of Glutathione-S-Transferase activity were obtained in Khark T-wharf (9.30 nmol/min/mg protein) and Naiband (6.63 nmol/min/mg protein). The maximum and minimum activity of EROD enzyme was measured in Khark T-wharf (0.04 µmol/min/mg protein) and Bushehr (0.002 µmol/min/mg protein). In total, no significant difference (P < 0.05) was observed regarding the relationship between enzymes and organisms available to PAH in different seasons. The results indicated the possible lack of response of the biomarkers present in this sea urchins, which is probably caused by a different immune system or the duration of exposure to pollution in these areas.