bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation treated in the pre‐ and post‐ponatinib era
Authors: Haddad Fadi G. , Sasaki Koji , Bidikian Aram , Issa Ghayas C. , Kadia Tapan , Jain Nitin , Alvarado Yesid , Short Nicholas J. , Pemmaraju Naveen , Loghavi Sanam , Patel Keyur P. , Kanagal‐Shamanna Rashmi , Yilmaz Musa , Masarova Lucia , Jabbour Elias , Kantarjian Hagop 
Published: July 2023

AbstractPatients with chronic myeloid leukemia (CML) and T315I mutation generally have a poor prognosis. Their outcome in the post‐ponatinib era remains unclear. We reviewed patients with CML in chronic (CP) or accelerated phase (AP) who developed a T315I mutation between March 15, 2004, and July 26, 2022. Patients were divided into CP, AP, or blastic phase (BP) at the time of mutation detection. Overall survival (OS) was defined from the time of mutation detection to the date of death or last follow‐up. We identified a total of 107 patients: 54 (51%) in CP, 14 (13%) in AP, and 39 (36%) in BP. One hundred and two patients received subsequent therapy after the T315I mutation was detected. At a median follow‐up of 75 months (95% CI, 41–110), the median OS was 49 months (95% CI, 26–73) and the 5‐year OS rate was 44%. Patients who were in CML‐CP at the time of mutation detection had better survival compared with those in AP or BP, with a median OS of 132, 31, and 6 months, and 5‐year OS rates of 70%, 37%, and 10%, respectively (p < .001). Patients with CML‐CP treated with ponatinib and/or asciminib had a 5‐year OS of 77% compared with 50% in those who received other treatments (chemotherapy, second‐generation tyrosine kinase inhibitors, homoharringtonine, and investigational drugs) (p = .14). In summary, patients with CML‐CP at the time of T315I mutation detection may have a relatively indolent disease course with a long‐term OS of 70%. Treatment with third‐generation tyrosine kinase inhibitors seemed to improve survival in patients with CML‐CP.
Mother's education and infant survival in Ethiopia
Authors: Liranso Endrias , Yang Fang 
Published: July 2023

AbstractObjectiveFew studies in Ethiopia have explored the impact of the mothers' education on infant survival. Therefore, this study aimed to identify and analyze the proximate factors in the relationship between maternal education and infant survival in Ethiopia.MethodsThis study used the nationally representative 2016 Ethiopian Demographic and Health Survey dataset. It analyzed a sample of 3831 newborn children using Cox regression models.ResultsThe findings revealed that infants born to educated mothers had lower odds of infant mortality than those born to mothers without formal education. Specifically, infants whose mothers had completed secondary school and had a better antenatal care attendance rate had 49.9% lower odds of infant mortality than those born to mothers with no formal education and a poor antenatal care attendance rate. Furthermore, infants whose mothers had at least some postsecondary education and who used delivery by health‐care professionals, clean drinking water, and improved toilet facilities had 65.3%, 56.3%, and 68.6% lower odds of infant mortality, respectively, than those born to mothers with no formal education and who did not use those facilities.ConclusionsThis study concluded that the mothers' educational disparity is intimately tied to infant mortality, and that access to formal education, mainly for women, increases infant survival in Ethiopia. Future research should focus on mothers without formal education who do not have access to antenatal care visits for safe pregnancy, delivery by health‐care professionals, clean drinking water, and improved toilet facilities in Ethiopia and elsewhere in Sub‐Saharan Africa.
Strain hypothesis and additional evidence of the GluN3A deficiency‐mediated pathogenesis of Alzheimer's disease
Authors: Yu Shan Ping , Jiang Michael , Berglund Ken , Wei Ling 
Published: July 2023

AbstractOur recent investigation revealed that deficiency of N‐methyl‐D‐aspartate (NMDA) receptor subunit GluN3A (NR3A) is a trigger for chronic neuronal hyperactivity and disruption of Ca2+ homeostasis, leading to sporadic Alzheimer's disease (AD) phenotypes. The identification of the amyloid‐independent pathogenesis was a surprise considering that GluN3A is a much less known NMDA receptor subunit with obscure function in aging adulthood, while the new concept of degenerative excitotoxicity as a decade‐long pathogenic mechanism of AD/dementia remains to be further delineated. With negative observations in GRIN3A−/− mouse, Verhaeghe et al. in their letter challenge the “odd” idea that lasting GluN3A deficiency is detrimental and responsible for the spontaneous progression of AD and cognitive decline. We now discuss the potential mouse strain hypothesis and experimental data in these two investigations, and provide additional evidence that further supports the validity and specificity of GluN3A deficiency in the development of AD and associated dementia.
Intracellular Molecules Induced Extracellular Peptide Self‐Assembly for Efficient and Effective In Situ Cell Purification
Authors: Li Cheuk Yin , Liang Zhenghua , Liu Lejian , Kuang Yi 
Published: July 2023

AbstractSynthetic messenger RNA (mRNA) switches are powerful tools for in situ cell purification, especially for cells derived from stem cells. However, the retention effectiveness of the target cells is limited by the leaky expression of toxic protein. The elimination efficiency of non‐target cells is also constrained due to the lack of signal amplification. In this study, we designed a novel approach that uses synthetic mRNA switch to convey intracellular marker molecule information into spatially controlled extracellular toxic assembly formation. The approach bypasses the use of toxic protein to ensure high target cell recovery effectiveness. Meanwhile, the marker molecule information is amplified at multiple levels to ensure high non‐target cell elimination effectiveness. Our approach can be tailored to meet various in situ cell purification needs, promising high‐quality in situ cell purification for a wide range of biomedical applications.
Stereoselective Plasmonic Interaction in Peptide‐tethered Photopolymerizable Diacetylenes Doped with Chiral Gold Nanoparticles
Authors: Joseph Jojo P. , Miglani Chirag , Maulik Antarlina , Abraham Shema R. , Dutta Avisek , Baev Alexander , Prasad Paras N. , Pal Asish 
Published: July 2023

AbstractDesigning polymeric systems with ultra‐high optical activity is instrumental in the pursuit of smart artificial chiroptical materials, including the fundamental understanding of structure/property relations. Herein, we report a diacetylene (DA) moiety flanked by chiral D‐ and L‐FF dipeptide methyl esters that exhibits efficient topochemical photopolymerization in the solid phase to furnish polydiacetylene (PDA) with desired control over the chiroptical properties. The doping of the achiral gold nanoparticles provides plasmonic interaction with the PDAs to render asymmetric shape to the circular dichroism bands. With the judicious design of the chiral amino acid ligand appended to the AuNPs, we demonstrate the first example of selective chiral amplification mediated by stereo‐structural matching of the polymer‐plasmonic AuNP hybrid pairs. Such ordered self‐assembly aided by topochemical polymerization in peptide‐tethered PDA provides a smart strategy to produce soft responsive materials for applications in chiral photonics.
Platinum and Frustrated Lewis Pairs on Ceria as Dual‐Active Sites for Efficient Reverse Water‐Gas Shift Reaction at Low Temperatures
Authors: Li Wenbin , Gan Jie , Liu Yuxuan , Zou Yong , Zhang Sai , Qu Yongquan 
Published: July 2023

AbstractThe low‐temperature reverse water‐gas shift (RWGS) reaction faces the following obstacles: low activity and unsatisfactory selectivity. Herein, the dual‐active sites of platinum (Pt) clusters and frustrated Lewis pair (FLP) on porous CeO2 nanorods (Ptcluster/PN−CeO2) provide an interface‐independent pathway to boost high performance RWGS reaction at low temperatures. Mechanistic investigations illustrate that Pt clusters can effectively activate and dissociate H2. The FLP sites, instead of the metal and support interfaces, not only enhance the strong adsorption and activation of CO2, but also significantly weaken CO adsorption on FLP to facilitate CO release and suppress the CH4 formation. With the help of hydrogen spillover from Pt to PN−CeO2, the Ptcluster/PN−CeO2 catalysts achieved a CO yield of 29.6 %, which is very close to the thermodynamic equilibrium yield of CO (29.8 %) at 350 °C. Meanwhile, the Ptcluster/PN−CeO2 catalysts delivered a large turnover frequency of 8720 h−1. Moreover, Ptcluster/PN−CeO2 operated stably and continuously for at least 840 h. This finding provides a promising path toward optimizing the RWGS reaction.
Breaking Local Charge Symmetry of Iron Single Atoms for Efficient Electrocatalytic Nitrate Reduction to Ammonia
Authors: Xu Jingwen , Zhang Shengbo , Liu Hengjie , Liu Shuang , Yuan Yuan , Meng Yahan , Wang Mingming , Shen Chunyue , Peng Qia , Chen Jinghao , Wang Xiaoyang , Song Li , Li Ke , Chen Wei 
Published: July 2023

AbstractThe electrochemical conversion of nitrate pollutants into value‐added ammonia is a feasible way to achieve artificial nitrogen cycle. However, the development of electrocatalytic nitrate‐to‐ammonia reduction reaction (NO3−RR) has been hampered by high overpotential and low Faradaic efficiency. Here we develop an iron single‐atom catalyst coordinated with nitrogen and phosphorus on hollow carbon polyhedron (denoted as Fe−N/P−C) as a NO3−RR electrocatalyst. Owing to the tuning effect of phosphorus atoms on breaking local charge symmetry of the single‐Fe‐atom catalyst, it facilitates the adsorption of nitrate ions and enrichment of some key reaction intermediates during the NO3−RR process. The Fe−N/P−C catalyst exhibits 90.3 % ammonia Faradaic efficiency with a yield rate of 17980 μg h−1 mgcat−1, greatly outperforming the reported Fe‐based catalysts. Furthermore, operando SR‐FTIR spectroscopy measurements reveal the reaction pathway based on key intermediates observed under different applied potentials and reaction durations. Density functional theory calculations demonstrate that the optimized free energy of NO3−RR intermediates is ascribed to the asymmetric atomic interface configuration, which achieves the optimal electron density distribution. This work demonstrates the critical role of atomic‐level precision modulation by heteroatom doping for the NO3−RR, providing an effective strategy for improving the catalytic performance of single atom catalysts in different electrochemical reactions.
Supramolecular Block Copolymers from Tricarboxamides. Biasing Co‐assembly by the Incorporation of Pyridine Rings
Authors: López‐Gandul Lucía , Morón‐Blanco Adrián , García Fátima , Sánchez L. Luis 
Published: July 2023

AbstractThe synthesis of a series of triangular‐shaped tricarboxamides endowed with three picoline or nicotine units (compounds 2 and 3, respectively) or just one nicotine unit (compound 4) is reported, and their self‐assembling features investigated. The pyridine rings make compounds 2–4 electronically complementary with our previously reported oligo(phenylene ethynylene)tricarboxamides (OPE‐TA) 1 to form supramolecular copolymers. C3‐symmetric tricarboxamide 2 forms highly stable intramolecular five‐membered pseudocycles that impede its supramolecular polymerization into poly‐2 and the co‐assembly with 1 to yield copolymer poly‐1‐co‐2. On the other hand, C3‐symmetric tricarboxamide 3 readily forms poly‐3 with great stability but unable to form helical supramolecular polymers despite the presence of the peripheral chiral side chains. The copolymer poly‐1‐co‐3 can only be obtained by a previous complete disassembly of the constitutive homopolymers in CHCl3. Helical poly‐1‐co‐3 arises in a process involving the transfer of the helicity from racemic poly‐1 to poly‐3, and the amplification of asymmetry from chiral poly‐3 to poly‐1. Importantly, C2v‐symmetric 4, endowed with only one nicotinamide moiety and three chiral side chains, self‐assembles into a P‐type helical supramolecular polymer (poly‐4) in a thermodynamically controlled cooperative process. The combination of poly‐1 and poly‐4 generates chiral supramolecular copolymer poly‐1‐co‐4, whose blocky microstructure has been investigated by applying the previously reported supramolecular copolymerization model.
L‐arginine and quaternary ammonium salt‐synergistically modified waterborne polyurethane for efficient antibacterial performance
Authors: Xu Mengting , Qian Hongxiang , Wang Qirun , Chang Shufang , Xu Xiaowei , Jia Runping , Han Sheng , Wu Tong , Wu Qingsheng 
Published: July 2023

AbstractAntibacterial waterborne polyurethane (WPU) is attracting increasing interest in a wide range of industrial applications due to its versatility and eco‐friendliness. However, single system antimicrobial WPU often does not meet the requirements of highly antimicrobial coating fields. Therefore, WPU was synergistically modified by L‐arginine (L‐Arg) and quaternary ammonium salts (QAs) in this study. They were introduced into the molecular structure of WPU by in‐situ emulsion polymerization to form the composite antibacterial system (WRPUs). The results showed that the composite systems had excellent antibacterial activity against both Escherichia coli and Staphylococcus aureus compared to single system. When the content of both L‐Arg and QAs was 7%, the antibacterial effect of WRPU7 was optimal, from the sum (E. coli: and S. aureus: ) of the inhibition circles of L‐Arg and QAs to 21.4 and 22.6 mm, respectively, net efficiency increase of 29% and 17%, fully reflecting the synergistic effect of Taken together, the results presented in this study confirm the significance of L‐Arg and QAs as synergistic antimicrobial building blocks. In this way, the antimicrobial performance of WPU can be significantly improved and better biocompatibility can be exhibited, thus broadening the application of WPU in highly antibacterial fields.
Preparation of thermoplastic polyurethane blend foams with controlled hydrophobicity via vapor induced phase separation
Authors: Pan Baohai , Lee Kyung Jin 
Published: July 2023

AbstractOil–water separation has attained great attention due to recent concern in environmental safety. Porous material from tailored engineering is the best candidate to selectively adsorb oil from water. Among the various porous materials, polymer based adsorbent has several advantages over others, in terms of controllable porosity and functionality. Here, we propose thermoplastic polyurethane (TPU) based blend foam through vapor induced phase separation method as a potential candidate for oil–water separation. In order to adjust hydrophobicity and compatibility of TPU blend, PDMS‐based TPU (Si‐TPU) is designed and synthesized to be blended with commercialized TPU. Si‐TPU with tailored weight ratio (PDMS/PTHF = 4/6) in synthetic level make it possible to achieve both of demanded hydrophobicity (the water contact angle increased from 85.19 ± 1.83° to 121.15 ± 3.79° after adding Si‐TPU) and controlling compatibility with CTPU during VIPS foaming. Thus, these well‐designed Si‐TPU can be utilized in various fields such as improving compatibility of polymer blend, adsorption efficiency of oil, and smart filtration, and so forth.
Indole derivatives targeting colchicine binding site as potential anticancer agents
Authors: Goel Bharat , Jaiswal Shivani , Jain Shreyans K. 
Published: July 2023

AbstractMicrotubules are appealing as intracellular targets for anticancer activity due to their importance in cell division. Three important binding sites are present on the tubulin protein: taxane, vinca, and colchicine binding sites (CBS). Many USFDA‐approved drugs such as paclitaxel, ixabepilone, vinblastine, and combretastatin act by altering the dynamics of the microtubules. Additionally, a large number of compounds have been synthesized by medicinal chemists around the globe that target different tubulin binding sites. Although CBS inhibitors have proved their cytotoxic potential, no CBS‐targeting drug had been able to reach the market. Several studies have reported design, synthesis, and biological evaluation of indole derivatives as potential anticancer agents. These compounds have been shown to inhibit cancer cell proliferation, induce apoptosis, and disrupt microtubule formation. Moreover, the binding affinity of these compounds to the CBS has been demonstrated using molecular docking studies and competitive binding assays. The present work has reviewed indole derivatives as potential colchicine‐binding site inhibitors. The structure–activity relationship studies have revealed the crucial pharmacophoric features required for the potent and selective binding of indole derivatives to the CBS. The development of these compounds with improved efficacy and reduced toxicity could potentially lead to the development of novel and effective cancer therapies.
Commentary: Dissection still a sticking point in the widespread use of DCB in PCI
Authors: Kleber Franz X. 
Published: July 2023

Key Points
Dissection is judged as a major hurdle for a more widespread use of DCB
Vessel stretching by either overdilatation or by straightening of very tortuous vessel segments are the predominant avoidable or modifiable risk factors for major dissection during predilatation or during DCB application.
While aggressive (pre‐)dilatation reduces the risk of elastic recoil, it increases the number of severe dissections. The known effects of positive vessel remodeling (1,2) might allow a more gentle angioplasty with residual stenosis of up to 30 % after DCB application without negative effects on long term results (3).
Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Authors: Park Dae Yong , An Seokyung , Jolly Neeraj , Attanasio Steve , Yadav Neha , Gutierrez Jorge A. , Nanna Michael G. , Rao Sunil V. , Vij Aviral 
Published: July 2023

AbstractBackgroundIntracoronary imaging modalities, including intravascular ultrasound (IVUS) and optical coherence tomography (OCT), provide valuable supplemental data unavailable on coronary angiography (CA) and have shown to improve clinical outcomes. We sought to compare the clinical efficacy of IVUS, OCT, and conventional CA‐guided percutaneous coronary interventions (PCI).MethodsFrequentist and Bayesian network meta‐analyses of randomized clinical trials were performed to compare clinical outcomes of PCI performed with IVUS, OCT, or CA alone.ResultsA total of 28 trials comprising 12,895 patients were included. IVUS when compared with CA alone was associated with a significantly reduced risk of major adverse cardiovascular events (MACE) (risk ratio: [RR] 0.74, 95% confidence interval: [CI] 0.63–0.88), cardiac death (RR: 0.64, 95% CI: 0.43–0.94), target lesion revascularization (RR: 0.68, 95% CI: 0.57–0.80), and target vessel revascularization (RR: 0.64, 95% CI: 0.50–0.81). No differences in comparative clinical efficacy were found between IVUS and OCT. Rank probability analysis bestowed the highest probability to IVUS in ranking as the best imaging modality for all studied outcomes except for all‐cause mortality.ConclusionCompared with CA, the use of IVUS in PCI guidance provides significant benefit in reducing MACE, cardiac death, and revascularization. OCT had similar outcomes to IVUS, but more dedicated studies are needed to confirm the superiority of OCT over CA.
Long range order for random field Ising and Potts models
Authors: Ding Jian , Zhuang Zijie 
Published: July 2023

AbstractWe present a new and simple proof for the classic results of Imbrie (1985) and Bricmont–Kupiainen (1988) that for the random field Ising model in dimension three and above there is long range order at low temperatures with presence of weak disorder. With the same method, we obtain a couple of new results: (1) we prove that long range order exists for the random field Potts model at low temperatures with presence of weak disorder in dimension three and above; (2) we obtain a lower bound on the correlation length for the random field Ising model at low temperatures in dimension two (which matches the upper bound in Ding–Wirth (2020)). Our proof is based on an extension of the Peierls argument with inputs from Chalker (1983), Fisher–Fröhlich–Spencer (1984), Ding–Wirth (2020) and Talagrand's majorizing measure theory (1980s) (and in particular, our proof does not involve the renormalization group theory).
Pharmacokinetic Profiles of a Proposed Biosimilar Ustekinumab (BFI‐751): Results From a Randomized Phase 1 Trial
Authors: Hausfeld Jeffrey N. , Challand Rodeina , McLendon Kristi , Macapagal Nathaniel , Bruce‐Staskal Pam , Fiaschetti Christina , Sampey Darryl B. 
Published: July 2023

AbstractBioFactura has developed a proposed biosimilar candidate (BFI‐751) to ustekinumab reference product. Results are reported for the first‐in‐human trial designed to compare the pharmacokinetic profiles, safety, and immunogenicity of BFI‐751 and ustekinumab reference products from the European Union and United States as well as similarity of the EU and US reference products. This was a multicenter, randomized, double blind, 3‐parallel‐group study (trial ID: NCT04843631). Healthy subjects were randomized to receive a single subcutaneous dose of 45 mg of BFI‐751, EU ustekinumab, or US ustekinumab. The pharmacokinetic parameters were area under the concentration–time curve (AUC) from time zero to infinity, AUC from time zero to the last quantifiable concentration, and maximum concentration. Safety, tolerability, and immunogenicity data were also reported. Pairwise comparisons among the 3 treatments all met the standard bioequivalence criteria that the 90% confidence interval of the geometric mean ratios of AUC from time zero to infinity, AUC from time zero to the last quantifiable concentration, and maximum concentration are completely within the acceptance interval of 80%–125%. There were no marked differences in the safety and tolerability profiles for subjects receiving BFI‐751 as compared to EU or US ustekinumab. Treatment‐emergent adverse events were mild to moderate for all treatment groups.