bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms
Authors: Lee Eun‐Jin , Lialios Peter , Curtis Micaila , Williams James , Kim Yoontae , Salipante Paul , Hudson Steven , Esch Mandy B. , Levi Moshe , Kitlinska Joanna , Alimperti Stella 
Published: January 2025

AbstractGlucocorticoids (GCs) are standard‐of‐care treatments for inflammatory and immune disorders, and their long‐term use increases the risk of osteoporosis. Although GCs decrease bone functionality, their role in bone microvasculature is incompletely understood. Herein, the study investigates the mechanisms of bone microvascular barrier function via osteoblast‐endothelial interactions in response to GCs. The animal data shows that prednisolone (Psl) downregulated the osteoblast function and microvessel number and size. To investigate the role of GCs in bone endothelial barrier function further, a bicellular microfluidic in vitro system is developed and utilized, which consists of three‐dimensional (3D) perfusable microvascular structures embedded in collagen I/osteoblast matrix. Interestingly, it is demonstrated that GCs significantly inhibit osteogenesis and microvascular barrier function by interfering with endothelial‐osteoblast interactions. This effect is triggered by MAPK‐induced phosphorylation of connexin43 (Cx43) at Ser282. Collectively, this study sheds light on microvascular function in bone disorders, as osteoporosis, and permits to capture dynamic changes in endothelial‐bone interactions under GCs by dissecting the MAPK/Cx43 mechanism and proposing this as a potential target for bone diseases.
Oriented Molecular Dipole‐Enabled Modulation of NiOx/Perovskite Interface for Pb‐Sn Mixed Inorganic Perovskite Solar Cells
Authors: Zhang Weihai , Liu Heng , Huang Tengcheng , Kang Lirui , Ge Junhan , Li Hui , Zhou Xia , Zhang Wenjun , Shi Tingting , Wang Hsing‐Lin 
Published: January 2025

AbstractNickel oxide (NiOx) is considered as a potential hole transport material in the fabrication of lead‐tin (Pb‐Sn) perovskite solar cells (PSCs) for tandem applications. However, the energy level mismatch and unfavorable redox reactions between Ni≥3+ species and Sn2+ at the NiOx/perovskite interface pose challenges. Herein, high‐performance Pb‐Sn‐based inorganic PSCs are demonstrated by modulating the NiOx/perovskite interface with a multifunctional 4‐aminobenzenesulfonic acid (4‐ABSA) interlayer. The 4‐ABSA interlayer induces the formation of an oriented dipole moment directed from NiOx to perovskite, effectively elevating the valance band maximum of the NiOx film, thus balancing the energy level difference and promoting charge carrier extraction of the device. Moreover, the 4‐ABSA molecules interact with both NiOx and perovskite, suppressing the reaction of highly active Ni≥3+ species with perovskites while regulating perovskite crystallization. This results in perovskite films with reduced defect density and enlarged grains. Consequently, a remarkable device efficiency of 17.4% is obtained, representing the highest reported value for Pb‐Sn‐based inorganic PSCs thus far. Furthermore, the 4‐ABSA interlayer enhances the UV‐radiation and operational stability of the resulting devices, maintaining over 80% and 90% of the initial efficiency after 240 h of UV‐light exposure and 480 h of 1 sun illumination, respectively.
Minute‐Level Room‐Temperature Switching and Long Cycle Stability of Thermochromic Inorganic Perovskite Smart Windows
Authors: Jin Jinlong , Zhang Jingjing , Zhang Jiyue , Chen Xiaowei , Zou Shengwen , Xin Yi , Liu Sihao , Liu Guangxin , Yan Xiaojun , Huang Jianmei 
Published: January 2025

AbstractPerovskite smart windows (PSWs) are widely investigated owing to excellent thermochromic properties, while restricted by poor transition performance and cycle stability. Herein, dimethyl sulfoxide vapor is utilized as an induction reagent for rapid reversible switching at room temperature between the colored and bleached phases. To obtain PSWs with different optical properties and transition performance, red CsPbIBr2, yellow Rb0.5Cs0.5PbIBr2 and brown CsSn0.1Pb0.9IBr2 are prepared through alloying. The perovskites can exhibit reversible switching at 27.4–34.3 °C within 1.9–5.1 min. Even after 100 cycles, they exhibit remarkable stability of luminous transmittance (retention ≥97.4%) and transition time (retention ≥97.6%). Experimental characterization proves that the reversible switching occurs between colored three‐dimension perovskite phase and bleached zero‐dimension perovskite phase. In the field test (air temperature = 21.6–26.5 °C), model houses with PSWs exhibit a maximum indoor temperature drop of 4.2 °C. Furthermore, they exhibit considerable temperature modulation ability up to 7.9 °C under a solar simulator (temperature of the control model house = 60 °C). The decrease in the luminous transmittance of the PSWs after 20 days is 2.9%, indicating excellent long‐term stability. This study offers PSWs with prominent transition performance and long cycle stability.
Full Disappearance of PC3‐Luc Prostate Tumors Mediated by Hyperthermia Under Low Intensity Ultrasound Application in the Presence of Magnetosomes
Authors: El Hedjaj Cynthia , Barret Eric , Chebbi Imène , Le Fèvre Raphaël , Maake Caroline , Guscetti Franco , Guyot François , Aubry Jean‐Francois , Seksek Olivier , Alphandéry Edouard 
Published: January 2025

AbstractIron oxide nanoparticles have been proposed for magnetic hyperthermia treatment of tumors. However, efficacy depends on the injection of large amounts of such nanoparticles and the equipment is costly. Here, a new thermal cancer treatment is described, in which a tumor containing a low concentration of nonpyrogenic pure iron oxide nanominerals coated with carboxy‐methyl‐dextran (M‐CMD), corresponding to modified magnetosomes, are exposed to ultrasound. Heating PC3 prostate carcinoma cells between 43 and 46°C using ultrasound in the presence of M‐CMD resulted in significant necrotic cell death. Furthermore, deposition of M‐CMD containing 3 µg of iron per mm3 of tumor in subcutaneous xenografts of PC3‐Luc tumors of 150 mm3 followed by 6 to 10 sessions of ultrasound application (1 W cm−2, 1 MHz) of 10 min each led to a tumor temperature of 43–46°C per session and to total tumor disappearance without regrowth over 6 months following treatment start. Sequential histological analyses of the tumor tissues revealed partial tumor occupation by M‐CMD and an increase in cell death over time. Neither lesions, nor magnetosome accumulation were found in microscopic sections of various internal organs collected from treated mice euthanized 6 months after the beginning of the treatment, indicating that M‐CMD may not lead to long‐term side effects.
Disease‐Adaptive Drug Delivery to the Inflamed Intestinal Mucosa Using Poly(Lactic‐Co‐Glycolic Acid)‐cyclodextrin Hybrid Nanocarriers
Authors: Schreiner Jonas , Brettner Felix E. B. , Steigert Sebastian , Haessler Annika , Mols Raf , Gier Stefanie , Jung Nathalie , Vogel‐Kindgen Sarah , Muschert Susanne , Augustijns Patrick , Windbergs Maike 
Published: January 2025

AbstractFluctuating severity of symptoms is a common hallmark of many inflammatory disorders, including inflammatory bowel disease (IBD). Addressing the pH changes during active and resting phases in IBD‐affected tissue, a disease‐adaptive nanocarrier system is designed for oral administration, enabling pH‐dependent local drug release. The hybrid carrier combines poly(lactic‐co‐glycolic acid) and an amphiphilic cyclodextrin derivative, with physicochemical properties and drug release kinetics controlled by adjusting polymer ratios. The systems exhibited baseline drug release at pH 5 with increased rates at pH 2, which is characteristic of actively inflamed IBD tissue. Assessing the impact of biomolecule adhesion, biocorona formation was studied using ex vivo human intestinal fluids. Corona composition highly depended on the patient's prandial state and the nanocarrier matrix, with proteins predominating in the fasted state and lipids in the fed state. Notably, differences in the attachment of proteins and free fatty acids are detected in the latter. Transport studies using human in vitro models of the inflamed intestine revealed mucosal accumulation, facilitating localized drug delivery and effectively reducing cytokine levels to basal concentrations. This hybrid system highlights the potential of disease‐adaptive drug release for inflammatory disease treatment and underscores the impact of biocorona formation on therapeutic performance in the gastrointestinal tract.
A Comprehensive Insight into the Phytochemistry, Pharmacology, and Therapeutic Potential of Digitalis purpurea L.
Authors: Karakoti Himani , Kumar Ravendra , Bargali Pooja , Mahawer Sonu Kumar , Rout Srutee , Mali Suraj N. , Santana de Oliveira Mozaniel 
Published: January 2025

AbstractDigitalis purpurea L., commonly referred to as foxglove, is a biennial herbaceous plant indigenous to Western and Central Europe and has become widely established in temperate areas across the globe. Renowned for its vibrant bell‐shaped flowers, D. purpurea has a long‐standing history of medicinal use, particularly for treating cardiovascular issues. The plant is abundant in secondary metabolites, such as cardiac glycosides, flavonoids, phenolic compounds, and alkaloids, which contribute to its significant pharmacological effects. Among these, the cardiac glycosides digoxin and digitoxin are notable active compounds extensively used in managing conditions like congestive heart failure and atrial fibrillation. In addition to its cardiotonic properties, D. purpurea is recognized for its anti‐inflammatory, antioxidant, anticancer, neuroprotective, and antimicrobial effects, generating increasing interest in contemporary medicine. This review examines the mechanisms through which these bioactive compounds operate, addresses safety considerations and potential toxicities related to D. purpurea use, and highlights current research trends. By emphasizing the necessity for careful administration and monitoring due to its narrow therapeutic window, this paper aims to underscore the therapeutic potential and future opportunities for D. purpurea in treating various diseases.
pH‐responsive Polyglycerol‐Nanogele zur Behandlung von Parodontitis durch antibakterielle und pro‐angiogenetische Wirkung
Authors: Ma Guoxin , Xu Ke , Yu Leixiao , Haag Rainer 
Published: January 2025

AbstractParodontitis ist eine entzündliche Erkrankung, die durch Mikroben ausgelöst wird und zu Knochenabbau sowie Gewebeschäden führt. In dem vorliegenden Artikel stellen wir einen Nanogel (NG)‐basierten Komplex vor, der zwei Funktion vereint: Er enthält den antimikrobiellen Wirkstoff Triclosan (TCS) und das pro‐angiogenetische Medikament Deferoxamin (DFO), um mikrobielle Erreger zu bekämpfen und die Geweberegeneration zu fördern. Das Nanogel (NG‐TCS‐DFO), das ausgehend von linearem Polyglycerin hergestellt wurde, weist eine wohldefinierte sphärische Morphologie auf und hat eine positiv geladene Oberfläche, die die Anhaftung von Bakterien begünstigt. Die schnelle und anhaltende Zersetzung des NG‐TCS‐DFO‐Komplexes in der sauren Umgebung eines Infektionsherdes bewirkt die gezielte Freisetzung von TCS und DFO. Das NG‐TCS‐DFO zeigt eine ausgeprägte Wirksamkeit bei der Eliminierung, der für Gingivitis verantwortlichen Bakterien Porphyromonas gingivalis, sowohl in planktonischer Form (99,9 %) als auch im Biofilm (99 %). Darüber hinaus fördert NG‐TCS‐DFO die Bildung von Blutgefäßen und die Migration von humanen Umbilikalvenen‐Endothelzellen (HUVECs). Durch die synergistische Wirkung von TCS und DFO zeigt der NG‐TCS‐DFO‐Komplex eine signifikante Regeneration des Knochengewebes und beschleunigt die Heilung von Parodontitis im Tiermodell. Dieses auf Polyglycerin basierende Nanogel bietet somit eine effiziente Kombinationstherapie zur Bekämpfung bakterienbedingter Erkrankungen.
Enzyme‐Inspired Single Selenium Site for Selective Oxygen Reduction
Authors: Zhang Peng‐Yang , Xu Xia , Yu Wen‐Song , Duan Zhi‐Yao , Huang Huan , Wang Tao , Fu Gang , Zhou Zhi‐You , Wang Yu‐Cheng , Sun Shi‐Gang 
Published: January 2025

AbstractLearning from nature has garnered significant attention in the scientific community for its potential to inspire creative solutions in material or catalyst design. The study highlights the design of a biomimetic single selenium (Se) site‐modified carbon (C) moiety that retains the unique reactivity of selenoenzyme with peroxides, which plays crucial roles in selectively catalyzing the oxygen reduction reaction (ORR). The as‐designed Se−C demonstrates nearly 100 % 4‐electron selectivity, evidenced by 0.039 % of H2O2 yield at 0.5 V versus reversible hydrogen electrode, outperforming commercial platinum (Pt) by 65 times. In situ X‐ray absorption spectroscopy and theoretical calculations attribute this exceptional selectivity to the enzyme‐like behaviors of the Se site to steal an O atom from peroxide intermediates. The second achievement is the significantly increased consecutive 2+2 electron selectivity. Benefiting from the enzyme‐like H2O2 reduction activity with a higher onset potential of 0.915 V compared to Pt at 0.875 V, the Se−C as a secondary catalytic site reduced the H2O2 yields of the Co−N−C, Fe−N−C, and N−C catalysts by 96 %, 67 %, and 98 %, respectively, via a consecutive 2+2 electron pathway. This also leads to more stable catalysts via protecting the active sites from oxidative attacks. This work establishes new pathways for precise tuning of reaction selectivity in ORR and beyond.
Harnessing Adsorbate‐Adsorbate Interaction to Activate C−N Bond for Exceptional Photoelectrochemical Urea Oxidation
Authors: Dang Kun , Wu Lei , Liu Siqin , Zhao Shenlong , Zhang Yuchao , Zhao Jincai 
Published: January 2025

AbstractThe photoelectrochemical (PEC) urea oxidation reaction (UOR) presents a promising half‐reaction for green hydrogen production, but the stable resonance structure of the urea molecule results in sluggish kinetics for breaking the C−N bond. Herein, we realize the record PEC UOR performance on a NiO‐modified n‐Si photoanode (NiO@Ni/n‐Si) by harnessing the adsorbate‐adsorbate interaction. We quantificationally unveil a dependence of the UOR activation barrier on the coverage of photogenerated surface high‐valent Ni‐oxo species (NiIV=O) by employing operando PEC spectroscopic measurements and theoretical simulations. The strong attraction between NiIV=O and adsorbed urea facilitates their N−O coupling while weakening the C−N bonding within urea, manifesting as the decreased UOR activation energy from 0.74 to 0.41 eV when the surface coverage of NiIV=O is enhanced from zero to full, corresponding to more than two orders of magnitude enhancement for the UOR rate. Furthermore, an industrial‐grade photocurrent density of 100 mA cm−2 is achieved at a potential as low as 1.08 VRHE by stimulating the NiIV=O accumulation under 10 Suns, which is 300 mV lower than the potential required for most reported electrochemical counterparts. This work opens new prospects for achieving high‐performance PEC urea oxidation via adsorbate‐adsorbate interaction.
Dual Active Site Covalent Organic Framework Anode Enables Stable Aqueous Proton Batteries
Authors: Zhao Qi , Ni Youxuan , Lu Yong , Xie Weiwei , Li Haixia , Yan Zhenhua , Zhang Kai , Li Yixin , Chen Jun 
Published: January 2025

AbstractAqueous proton batteries (APBs) have attracted increasing interest owing to their potential for grid‐scale energy storage with extraordinary sustainability and excellent rate abilities. However, there are limited anode materials and it remains a great challenge to effectively balance capacity and cycling performance. Here, we report a covalent organic framework containing C=O and C=N dual active sites (TABQ‐COF) as a high‐capacity and long‐cycle anode for proton batteries. The proton storage ability of the dual active sites and the up to nine proton redox chemistry mechanisms for each repetitive unit have been demonstrated by experiments and density functional theory calculations. The insoluble TABQ‐COF electrode displayed a remarkably high specific capacity of 401 mAh g−1, outstanding cycling stability (100 % capacity retention after 7500 cycles) and high rate performance (90 mAh g−1 at 50 A g−1). When coupling with a MnO2 cathode, the constructed TABQ‐COF//MnO2 battery achieves a reversible capacity of 247 mAh g−1 at 5 A g−1, with a remarkable capacity retention of 100 % over 10000 cycles. Furthermore, the TABQ‐COF//MnO2 battery can operate well and shows high capacity and cycle stability in a frozen electrolyte at −40°C, implying great potential for energy storage at extreme temperatures.
Distinkte Valenzzustände des [4Fe4S]‐Clusters in der Hydrogenase CrHydA1
Authors: Heghmanns Melanie , Yadav Shalini , Boschmann Sergius , Selve Victor R. , Veliju Astrit , Brocks Claudia , Happe Thomas , Pantazis Dimitrios A. , Kasanmascheff Müge 
Published: January 2025

AbstractEisen‐Schwefel‐Cluster spielen eine entscheidende Rolle im Elektronentransport vieler essentieller Enzyme, einschließlich der [FeFe]‐Hydrogenasen. Diese Studie konzentriert sich auf den [4Fe4S]‐Cluster ([4Fe]H) der minimalen [FeFe]‐Hydrogenase aus Chlamydomonas reinhardtii (CrHydA1), welcher mittels moderner Spektroskopiemethoden, gezielter Mutagenese, Molekulardynamik‐Simulationen und QM/MM‐Berechnungen untersucht wurde. Wir geben Einblick in die komplexe elektronische Struktur von [4Fe]H und seine Rolle in der Katalyse von CrHydA1, welche als ein Modell für das Verständnis von [FeFe]‐Hydrogenasen dient. Es wurden mindestens zwei verschiedene Zustände innerhalb der Apo‐Form von CrHydA1 identifiziert, die als 4Fe−R und 4Fe−A bezeichnet werden, mit individuellen Redoxpotentialen und pH‐Abhängigkeiten. Unsere Ergebnisse zeigen, dass diese Spezies durch ein komplexes Zusammenspiel von struktureller Heterogenität und Umlagerungen von Valenzisomeren entstehen, die durch die Residuen der zweiten Koordinationssphäre beeinflusst werden. Wir vermuten, dass das Gleichgewicht zwischen 4Fe−R und 4Fe−A die Kontrolle des Elektronentransfers in Abwesenheit akzessorischer FeS‐Cluster ermöglicht, die typischerweise in anderen [FeFe]‐Hydrogenasen vorkommen. Die in dieser Studie gewonnenen Erkenntnisse verbessern nicht nur unser Verständnis von [FeFe]‐Hydrogenasen, sondern bilden auch eine wichtige Grundlage für zukünftige Untersuchungen zur Analyse anderer FeS‐Cluster in verschiedenen biologischen Systemen.
Regulating Water Molecules via Bioinspired Covalent Organic Framework Membranes for Zn Metal Anodes
Authors: Zhang Sida , Chen Jiashu , Chen Weigen , Su Yiwen , Gou Qianzhi , Yuan Ruduan , Wang Ziyi , Wang Kaixin , Zhang Wentao , Hu Xiqian , Zhang Zhixian , Wang Pinyi , Wan Fu , Liu Jie , Li Beibei , Wang Yifei , Zheng Guangping , Li Meng , Sun Jingyu 
Published: January 2025

AbstractThe Zn metal anode in aqueous zinc‐ion batteries (AZIBs) faces daunting challenges including undesired water‐induced parasitic reactions and sluggish ion migration kinetics. Herein, we develop three‐dimensional covalent organic framework (COF) membranes with bioinspired ion channels toward stabilized Zn anodes. These COFs, featured by zincophilic pyridine‐N sites, enable effective regulation of water molecules at the anode‐electrolyte interphase. Systematic experimental analysis and theoretical simulations reveal the optimized COF‐320N membrane functions as ion pumps, accordingly facilitating Zn2+ transport and inhibiting direct contact between Zn anode and free water molecules. Consequently, the bio‐inspired strategy achieves improved Zn2+ transference number (0.61), rapid de‐solvation kinetics, and suppressed hydrogen evolution. The assembled Zn||MnO2 pouch cell integrated with COF‐320N membrane exhibits favorable electrochemical performances. Such a bioinspired concept for optimizing Zn anodes opens new pathways in developing advanced energy storage devices.
Superconjugated Anthraquinone Carbonyl‐Based Covalent Organic Framework as Anode Material for High‐Performance Aqueous Ammonium‐Ion Batteries
Authors: Liu Jiahui , Guo Keyan , Guo Wen , Chang Jiaqi , Li Yongsheng , Bao Fuxi 
Published: January 2025

AbstractCovalent organic frameworks (COFs) have recently been emerged as promising anode candidates for aqueous ammonium ion batteries (AAIBs), but suitable COFs need to be developed and the energy storage mechanisms need to be further investigated. Here we report an anthraquinone carbonyl‐containing COF as anode for AAIBs, which exhibits a high specific capacity of 141 mAh g−1 at 0.1 A g−1 and good cycling stability with 90 % retention after 8000 cycles at 6 A g−1. We find that the anthraquinone carbonyls (denoted as C=O1) with superconjugated structure in the COF can form hydrogen bonds with NH4+ ions, thus serving as optimal sites and providing the major contribution to NH4+ ion storage, whereas another type of carbonyls (denoted as C=O2) in the same COF suffers from enol‐keto tautomerism, which prevents the formation of hydrogen bonds and is therefore unfavourable for NH4+ ion storage. This is further verified by the theoretical calculations where the hydrogen bonding rate of C=O1 groups is much faster than that of C=O2. This work not only provides insights into understanding the mechanism of NH4+ ion storage, but also offers new ideas for the design of advanced COF‐based materials for AAIBs.
A Robust Dual‐Layered Solid Electrolyte Interphase Enabled by Cation Specific Adsorption‐Induced Built‐In Electrostatic Field for Long‐Cycling Solid‐State Lithium Metal Batteries
Authors: Wang Xi‐Long , Li Yuan , Liu Jia , Yang Shi‐Jie , Hu Jiang‐Kui , Mai Wei‐Qi , Wen Rui , Yuan Hong , Huang Jia‐Qi 
Published: January 2025

AbstractSolid‐state lithium (Li) metal batteries (SSLMBs) are considered as one of the most promising next‐generation battery technologies due to their high energy density and intrinsic safety. However, interfacial issues such as side reactions and Li dendrite growth severely hinder the practical application of SSLMBs. In this contribution, we proposed a cationic built‐in electrostatic field to drive the generation of an anion‐derived dual‐layered solid electrolyte interphase (SEI). The specific adsorption of tributylmethyl‐phosphonium bis(trifluoromethanesulfonyl)imide (TMPB) cations onto negatively charged Li anode surface significantly prevents interfacial side reactions between vulnerable polyethylene oxide (PEO) and Li metal. More importantly, the formed cationic built‐in electrostatic field induces the targeted trapping of Li‐salt anions onto the Li metal surface, leading to the generation of an anion‐derived dual‐layered SEI, composed of a mechanically flexible organic‐rich surface layer and a Li‐ion conductive inorganic‐rich bottom layer. As a result, the Li||Li cell demonstrated an extended lifespan of over 1900 hours with the reduced polarization voltage. The Li||LiFePO4 full cell also exhibited excellent cycling stability, maintaining an average Coulombic efficiency of 99.7 % over 200 cycles at 0.5 C. This work provides valuable insights into mitigating interfacial degradation and promoting uniform Li deposition through surface electrostatic field regulation.