bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social media and mental health in students: a cross-sectional study during the covid-19 pandemic
Authors: Nazari Abouzar , Hossennia Maedeh , Garmaroudi Gholamreza , Torkian Samaneh 
Published: March 2023

Abstract
Background:
Social media causes increased use and problems due to their attractions. Hence, it can affect mental health, especially in students. The present study was conducted with the aim of determining the relationship between the use of social media and the mental health of students.
Materials and methods:
The current cross-sectional study was conducted in 2021 on 781 university students in Lorestan province, who were selected by the Convenience Sampling method. The data was collected using a questionnaire on demographic characteristics, social media, problematic use of social media, and mental health (DASS-21). Data were analyzed in SPSS-26 software.
Results:
Shows that marital status, major, and household income are significantly associated with lower DASS21 scores (a lower DASS21 score means better mental health status). Also, problematic use of social media (β = 3.54, 95% CI: (3.23, 3.85)) was significantly associated with higher mental health scores (a higher DASS21 score means worse mental health status). Income and social media use (β = 1.02, 95% CI: 0.78, 1.25) were significantly associated with higher DASS21 scores (a higher DASS21 score means worse mental health status). Major was significantly associated with lower DASS21 scores (a lower DASS21 score means better mental health status).
Conclusion:
This study provides further evidence of the association between problematic social media use and poor mental health among college students and supports future research to focus on the underlying mechanisms of problematic use of social media.
M6A Methylation Modification–Mediated Mucosal Immune Microenvironment in Crohn's Disease
Authors: Lan Shui-Qing , Huang GuiLiu , Huang ZanSong 
Published: March 2023

Abstract

Objective
To explore the pathogenesis of Crohn's disease by revealing the relationship between m6A methylation and Crohn's disease
Methods
The GEO (GENE EXPRESSION OMNIBUS) database was used to download the dataset GSE186582 on Crohn's disease, including standard tissue samples and Crohn's disease tissue samples, and the Expression of M6A-related genes in the calibrated dataset was obtained. Through the observation and comparison of the random forest tree method and machine learning method, it was determined that the random forest tree model could be used to screen the characteristic genes of diseases. Samples were divided into subtypes by the expression of m6A-related genes, and the relationship between different types and immune cells was analyzed and verified by principal component analysis. The expression of M6A-related genes and the relationship between the genotyped samples and immune cells were analyzed. We classified Crohn's disease according to the expression of differential genes, finally established the corresponding relationship between different types by Sankey diagram and analyzed the expression of Crohn's disease-related disease genes in two different types.
Results
By comparing the model construction methods, we found that the residual value of the random forest tree model method was low, and the area under the ROC curve was 1. Therefore, we chose the random forest tree method to construct the model and screen characteristic genes and found 11 methylation-related genes related to m6A in Crohn's disease, such as RBM15, YTHDF3 and RBM15B. According to the expression of 11 M6A-related genes, the samples were divided into two subtypes: activated B cells, immune B cells and MDSC (myeloid-derived inhibitory cells) expressed more than the B subtype (P value is less than 0). There was a significant positive correlation between the METTL3 gene, M6A recognition enzyme HNRNPA2B and activated CD4 + T cells. The expressions of activated B cells, MDSC and immune B cells in genotype B were significantly higher than those in genotype A (P < 0.05).
Conclusion
m6A modulators play an essential role in Crohn's disease, and the study of their patterns can guide future immunotherapy strategies for Crohn's disease
Allogeneic Hematopoietic Stem Cell Transplantation for Adults with Therapy-Related Acute Myeloid Leukemia: a Retrospective Multicentre Study on behalf of the SFGM-TC
Authors: Tavernier Emmanuelle , Rey Gaëlle , Daguenet Elisabeth , Bonjean Paul , Devillier Raynier , Fegueux Nathalie , Forcade Edouard , sr micha , chevalier patrice , robin marie , Suarez Felipe , Micol Jean-Baptiste , labussiere helene , Bilger Karin , Daguindau Etienne , Bay Jacques Olivier , Fayard Amandine , BULABOIS Claude-Eric , Nguyen-Quoc Stéphanie , Genthon Alexis , Orvain Corentin , TURLURE Pascal , Loschi Michael , Poire Xavier , Guillerm Gaella , Beguin Yves , Maillard Natacha , Mear jean-baptiste , Chalayer Emilie , Cornillon Jerome 
Published: March 2023

Abstract
We report the results from a multicentre retrospective study of 220 adult patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) for therapy-related acute myeloid leukemia (t-AML). Median age at t-AML diagnosis was 56 years, with a prior history of haematological (45%) or gynaecological neoplasia (37%). Median time from cytotoxic exposure to t-AML diagnosis was 54.7 months. At transplant, around 20% of patients had measurable residual disease and 3% of patients were not in complete remission. The median follow-up was 21.4 months (Q1-Q3, 5.9–52.8). At 12 months, overall survival (OS), event-free survival (EFS), and graft-versus-host-disease (GVHD)-free-relapse-free survival (GRFS) were 60.7% (95% CI 54.6–67.5), 52.8% (95% CI 46.5–68.4), and 44.1% (95% CI 37.6–51.8), respectively. At 5 years, OS, EFS, and GRFS were 44.1% (95% CI 37.4–52.1), 40.4% (95% CI 33.9–48.1), and 35.3% (95% CI 28.8–43.3), respectively. At last follow-up, 44% of patients were in complete remission (n = 96) and transplant-related mortality accounted for 39% of all deaths (n = 119). Multivariable analysis revealed that uncontrolled t-AML at transplant was associated with lower EFS (HR 1.94, 95% CI 1.0-3.7, p = 0.041). In conclusion, alloHSCT for t-AML shows encouraging results and offers additional opportunity with the emergence of novel pre-graft therapies.
Distinct decadal modulation of Atlantic-Niño influence on ENSO
Authors: Park Jae-Heung , Kug Jong-Seong , Yang Young-Min , Sung Mi-Kyung , Kim Sunyong , Kim Hyo-Jeong , Park Hyo-Jin , An Soon-Il 
Published: March 2023

AbstractThe summer and winter Atlantic-Niño events are capable of triggering the El Niño–Southern oscillation (ENSO) in the subsequent winter with half-year and one-year leads, respectively. Here, we examine the interdecadal modulation of the effect of the Atlantic-Niños on ENSO by analyzing observational reanalysis datasets. During mid-Twentieth Century, the winter Atlantic-Niño intensified and expanded westward as a result of local warm and humid climates. Accordingly, convection occurred from the Amazon to the Atlantic, and the resulting atmospheric teleconnection induced trade wind discharging and equatorial Kelvin waves, leading to the development of ENSO. In contrast, during late-Twentieth Century, summer Atlantic-Niño events expanded westward as linked to the South American low-level jet, which induced strong convection over the Amazon to the Atlantic. This caused a modulated Walker circulation, which in turn triggered ENSO. We conclude that the prerequisite for the lagged relationship between Atlantic-Niño and ENSO events is a wide convection over the tropical South America to the Atlantic, which influences the level of atmospheric teleconnection toward the Pacific. It seems that climatological Pacific mean state plays some role in determining the lead-time of the Atlantic-Nino effect on the ENSO.
Effect of pneumovesicoscopic Cohen surgery with adjustable suspension technique through natural channel on the treatment of primary vesicouretral reflux disease in infants
Authors: Cui Xu , Huang Wen-Hua , Wang Yun-Jin , Chen Liu , Zhang Jian-Qin , Zhou Chao-Ming 
Published: March 2023

Abstract
Objective:The objective of this study was to evaluate the safety and efficacy of pneumovesicoscopic Cohen surgery with adjustable suspension technique through natural channel on the treatment of primary vesicouretral reflux disease in infants.
Methods: This study retrospectively analyzed the clinical data of 31 infants who underwent pneumovesicoscopic Cohen surgery with adjustable suspension technique through natural channel in our hospital from January 2019 to December 2020. We also collected the clinical data of 29 infants who underwent open Cohen surgery in our hospital from January 2015 to December 2018 as a control. The clinical efficacy of the two groups was compared.
Result: All the pneumovesicoscopic Cohen surgery were successfully completed, and no one transferred to open surgery. The amount of bleeding, duration of postoperative analgesic, duration of postoperative hematuria, incision size and length of hospital stay in the pneumovesicoscopic surgery group were significantly lower than those in the open surgery group (P<0.05). The operation time of pneumovesicoscopic surgery group was significantly longer than that of open surgery group (P<0.05). Both groups were followed up 6 months after surgery. At the 6 months follow-up time, there were no significant differences in the degree of hydronephrosis, renal scar, renal atrophy, glomerular filtration rate, KIM-1 and MCP-1 expression between the two groups (P>0.05).
Conclusion: Pneumovesicoscopic Cohen surgery with adjustable suspension technique through natural channel on the treatment of primary vesicouretral reflux disease in infants was safe and effective, it had the advantages of less trauma, quick recovery and good cosmetic effect.
Bone Scan Index (BSI) scoring by using bone scintigraphy and circulating tumor cells (CTCs): predictive factors for enzalutamide effectiveness in patients with castration-resistant prostate cancer and bone metastases
Authors: Hirano Hisashi , Nagata Masayoshi , Nagaya Naoya , Nakamura So , Ashizawa Takeshi , Lu Yan , Kawano Haruna , Kitamura Kosuke , Sakamoto Yoshiro , Fujita Kazuhiko , Isobe Hideyuki , Tsujimura Akira , Muto Satoru , Horie Shigeo 
Published: March 2023

Abstract
Background
Reports of Bone Scan Index (BSI) calculations as imaging biomarkers to predict survival in patients with metastatic castration-resistant prostate cancer (mCRPC) have been mainly from retrospective studies. To evaluate the effectiveness of enzalutamide (ENZ) in Japanese patients with mCRPC and bone metastases using BSI (bone scintigraphy) and circulating tumor cell (CTC) analysis.
Methods
Prospective, single-arm study at Juntendo University affiliated hospitals, Japan. Patients were administered 160 mg ENZ daily, with 3-monthly assessments: BSI, prostate specific antigen (PSA), CTC and androgen receptor splicing variant-7 (AR-V7) status. Primary endpoint: BSI-decreasing rate after ENZ treatment. Secondary endpoints: PSA and progression free survival (PFS). Statistical analyses included the Wilcoxon t-test, Cox proportional hazard regression analysis, and log-rank test.
Results
Median observation period: 17.9 months, and median PFS: 13.8 (2.0-43.9) months (n = 90 patients). At 3 months 67% patients showed a ≥ 50% PSA reduction, and 70% after ENZ treatment. At 3 months 20% patients showed a ≥ 50% BSI reduction (10% complete response [CR]; BSI value 0.00), and 38% patients (29% CR) at study end. PSA decline (3 months) significantly prolonged median PFS: 18.0 (estimated) vs 6.4 months (HR 2.977 [95% CI: 1.53–5.78], p = 0.001). Best BSI decline response significantly prolonged PFS: 18.1(estimated) vs 7.8 months (HR 2.045 [95% CI: 1.07–3.90], p = 0.029). CTC negative status (n = 20) significantly prolonged PFS: 13.4 [estimated] vs 8.6 months (HR 2.366, 95% CI: 0.97–5.71, p = 0.041). CTC positive/AR-V7 positive status significantly reduced PFS: 5.9 months (HR 8.56, 95%CI: 2.40–30.43, p = 0.0087).
Conclusions
PSA reduction (3 months), BSI reduction (after ENZ), and a negative CTC status were significant predictive factors for ENZ efficacy in patients with mCRPC.
Microbial Communities and Sulfur Isotopes of the Cenozoic Sulfurous Oil Reservoirs in the Southwestern Qaidam Basin, Western China
Authors: JIAO Yue , AN Liyun , WANG Wei , MA Jian , WU Chaodong , WU Xiaolei 
Published: March 2023

Abstract
Sulfur-rich natural gas reservoirs have been discovered in the southwestern margin of the Qaidam Basin, marking a breakthrough in the Cenozoic natural gas exploration. 16S rRNA extraction and analysis were performed on crude oil samples from H2S-rich reservoirs at the Yuejin, Shizigou and Huatugou profiles to understand the sulfurous gas origination, which was also intergrated with carbon and hydrogen isotopes of alkane and sulfur isotopes of H2S collected from the Yingxiongling Area. Results show that microorganisms in crude oil can be classified into Proteobacteria, Planctomycetes, Firmicutes, Bacteroidetes, Haloanaerobe, etc., which can survive in hypersaline reservoirs. Methanogens and nitrate-reducing bacteria are popular in three profiles, while sulfate-reducing bacteria are abundant in Yuejin and Huatugou profiles, which contributed to methane and H2S in natural gas. The gas components and sulfur isotopes at the Yingxiongling Area show that the natural gas was mixed by coal-type gas and oil-type gas, which was primarily derived from thermal degradation, and natural gas from the Yuejin and Huatugou profiles also origniated from biodegradation. It agrees well with the tested microbial sequencing, i.e., H2S-rich natural gas from the Cenozoic reservoirs in the southwest margin of the Qaidam Basin was primarily thermal genesis, with microbial genesis of secondary importance.
Quick insights into whisky – investigating rapid and efficient methods for sensory evaluation and chemical analysis
Authors: Haug Helen , Grasskamp Andreas T. , Singh Satnam , Strube Andrea , Sauerwald Tilman 
Published: March 2023

Abstract
The evaluation of aroma properties of beverages both analytically as well as with human sensory is a challenging task and most often related to time- and cost-intensive analyses. Whisky is a spirit offering a wide variety of aroma impressions caused by a complex mixture of aroma active compounds. In the present study, methods for the efficient evaluation of aroma characteristics are evaluated for 16 whisky samples of different origins (Scotch and American). Rate all that apply (RATA) was applied as a rapid sensory method for the sensory evaluation of whiskies. Sensory evaluation of the samples led to the determination of eight significant aroma attributes: Caramel / cream caramel / toffee, vanilla, (canned) peach, phenolic, smoky, fruity, flowery and (fermented) apple / cider. Chemical analysis was conducted by stir bar sorptive extraction (SBSE) coupled to gas chromatography mass spectrometry in combination with an in-house data processing tool for automated analyte detection. Through chemical analysis of the whisky samples and automated compound detection, over 200 mostly aroma-active volatiles were reported. To test both approaches for their potential for sample classification, a simple classification problem (Scotch vs. American) was applied. Linear discriminant analysis (LDA) indicates both that sensory evaluation by RATA (97.86%) and the applied analytical procedure (96.94%) are suitable for the distinction between the two whisky types. For both approaches, markers were identified for the classification. These investigations build a solid foundation for the implementation of a versatile platform for rapid and efficient aroma evaluation for various foodstuffs and beverages.
Tracking exceptional points above laser threshold
Authors: El-Ganainy Ramy , Yacomotti Alejandro M. , Ge Li , Ji Kaiwen , Beaudoin Gregoire , Sagnes Isabelle , Raineri Fabrice , Zhong Qi 
Published: March 2023

Abstract
Recent studies on non-Hermitian optical systems having exceptional points (EPs) have revealed a host of unique characteristics associated with these singularities, including unidirectional invisibility, chiral mode switching and laser self-termination, to mention just a few examples. The vast majority of these works focused either on passive systems or active structures where the EPs were accessed below the lasing threshold, i.e. when the system description is inherently linear. In this work, we experimentally demonstrate that EP singularities in coupled semiconductor nanolasers can be accessed and tracked above the lasing threshold, where they become branch points of a nonlinear dynamical system. Contrary to the common belief that unavoidable cavity detuning will impede the formation of an EP, here we demonstrate that this same detuning is necessary for compensating the carrier-induced frequency shift, hence restoring the nonlinear EP in the lasing regime. Furthermore, unlike linear non-Hermitian systems, we find that the spectral location of EPs above laser threshold varies as a function of total pump power and can therefore be continuously tracked. Our work is a first step towards the realization of lasing EPs in more complex laser geometries, and enabling the enhancement of photonic local density of states through non-Hermitian symmetries combined with nonlinear interactions in coupled laser arrays.
Investigating Travel Behavioral Changes Throughout 10 Years: A Case Study on Southeast Michigan
Authors: Alhomaidat Fadi , Alhadidi Taqwa , Eljufout Tamer , Abushattal Mousa 
Published: March 2023

Abstract

This paper presents a descriptive analysis of travel behavior over ten years using household survey data collected by the Southeast Michigan Council of Governments (SEMCOG) in 2005 and 2015, respectively. The data used in this work were 12,000 and 6,500 sample sizes for 2005 and 2015, respectively. Generally, results indicated that a 12% reduction for all trip rates occurred during the study period. On the other hand, trip rates for multiple age ranges, including the elderly, increased from 2005 to 2015. Also, the average travel distance for all modes increased during the study period, and transit was mainly used for long travel distances. Also, several spatiotemporal changes in human travel behavior were analyzed using different travel indicators, namely: travel time, trip purpose, travel mode, and travel distance. The analysis results show the change in travel behavior across different counties in the SEMCOG area during the study period. The study indicates that the travel time changes across different travel modes, as well as trip purposes, were influenced by the economic impact change along the study period. It was found that travel time distributions for most purposes are concentrated on trips of travel time shorter than 40 minutes.
Ageism, welfare, and the energy transition: a comparative analysis of the energy practices of the elderly in Poland and Norway
Authors: Szulecki Kacper , Neerland Maria Aspen , Tomter Håkon , Wæringsaasen Cecilie Agathe Blomberg , Żuk Paweł , Żuk Piotr 
Published: March 2023

Abstract
Background
One of the potential dimensions on which exclusion and injustice may occur in energy transitions is age. That age-based pattern of exclusion – ageism – has recently been conceptualized in the context of decarbonization as energy ageism. This paper offers a comparative empirical analysis of the impact of energy poverty as well as the senior citizens’ outlook towards an imminent energy transition in two European states: Norway and Poland.
Results
Drawing on interviews and focus groups with Polish and Norwegian seniors, we present the differences and similarities between the two countries, and the determinants of energy ageism, as well as the concept’s overall applicability and empirical usefulness. We find that socioeconomic conditions outweigh ageism, that is, the resilience of senior citizens in dealing with energy poverty during a transition is conditioned by their material standing and welfare state robustness rather than age-based. An important factor is household heating technology, which combined with economic vulnerability can push some individuals into energy poverty while others using alternative sources of heat can navigate through energy crises unscathed.
Conclusions
We note the importance of mainstreaming social inclusion considerations in energy policy and of targeted digital competence building which can enhance senior citizen integration in the energy transition. Lower levels of digital competences among senior citizens certainly play a role and need to be addressed with education programs to increase senior citizens participation. In both countries, household heating is a major issue and heating sources are strong predictors of energy poverty and regulatory measures and subsidies should be designed at national, regional, and municipal level to assist vulnerable groups in this area.
LncRNA expression signature identified using genome-wide transcriptomic profiling to predict lymph node metastasis in patients with stage T1 and T2 gastric cancer
Authors: Dong Zhebin , Xiang Hanting , Wu Hengmiao , Chen Zhengwei , Chen Sangsang , He Yicheng , Li Hong , Yu Weiming , Liang Chao 
Published: March 2023

Abstract
Background: Lymph node (LN) status is vital to indicate and evaluate the curative potential of relatively early gastric cancer (GC; T1–T2) treatment (endoscopic or surgery). Currently, there is a lack of robust and convenient methods to identify such metastasis before therapeutic decision-making; therefore, there is an urgent need to identify biomarkers that could aid the identification of patients with LN metastasis.
Methods: Genome-wide expression profiles of long noncoding RNA (lncRNA) in primary T1 gastric cancer data from The Cancer Genome Atlas (TCGA) was used to identify an lncRNA‑expression signature capable of detecting LN metastasis of GC, and establish a 10-lncRNA risk‑prediction model based on deap learning. The performance of the lncRNA panel in diagnosing LN metastasis was evaluated using both in silico and clinical validation methods. In silico validation was conducted using TCGA and Asian Cancer Research Group (ACRG) datasets. Clinical validation was performed on T1 and T2 patients, and the panel's efficacy was compared with that of traditional tumor markers and computed tomography (CT) scans.
Results: Profiling of genome-wide RNA expression identified a panel of lncRNA to predict LN metastasis in T1 stage gastric cancer (area under the curve (AUC) = 0.961). A 10-lncRNA risk-prediction model was then constructed, which was validated successfully in T1 and T2 datasets (TCGA, AUC = 0.852; ACRG, AUC = 0.834). Thereafter, the clinical performance of the lncRNA panel was validated in clinical cohorts (T1, AUC = 0.812; T2, AUC = 0.805; T1+T2, AUC = 0.764). Notably, the 10-lncRNA panel demonstrated significantly better performance compared with CT and conventional tumor markers (carcinoembryonic antigen and carbohydrate antigen 19-9).
Conclusions: The novel 10-lncRNA could diagnose LN metastasis robustly in relatively early gastric cancer (T1–T2), with promising clinical potential.