bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting the Proliferation of Osteoarthritis Chondrocytes by Resolvin D1 Regulating NLRP3/caspase-1 Signaling Pathway
Authors: Wang Xiaoying , Yang Mingfeng , Yu Guanghui , Qi Jianhong , Jia Qingwei , Liu Shuai , Jiang Wenjun , Su Siwei , Chi Zhiwei , Wang Ruonan , Liu Minghan , Song Hongqiang 
Published: April 2023

AbstractBackgroundResolvin D1 could reduce the inflammatory, catabolic response of OA chondrocyte, and promote the repair of various tissues.Our goal was to explore whether RvD1 could inhibit NLRP3/caspase-1 signaling pathway, slow down the occurrence of pyroptosis of OA chondrocytes, and then promote the proliferation of OA chondrocytes and repair of articular cartilage.MethodsAnimal care and use protocols comply with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.After the rat osteoarthritis model was established, RvD1 was injected and a control group trial was set up, Joint specimens were then collected.The micro-CT system was used to determine the acquisition of a 3D model of the rat knee joint. Chondrocytes were stained with toluidine blue, Then the cover slip was examined under a light microscope. EDU was used to detect the proliferation of chondrocytes.Western Blot,RT-qPCR and Immunofluorescence was used to detect markers in experiments.ResultsCompared with the control group, RvD1 can promote OA chondrocytes multiplication and inhibit chondrocytes pyrosis by regulating the cell cycle.Belnacasan is a specific inhibitor of caspase-1, Treatment of OA chondrocytes with Belnacasan and RvD1 showed that Belnacasan could specifically inhibit the conduction of pyroptosis pathway induced by caspase-1, and the synergistic inhibitory effect with RvD1 was more significant.ConclusionRvD1 promotes the proliferation of OA chondrocytes by inhibiting the expression of caspase-1 to regulate NLRP3/caspase-1 signaling − 8 pathway. At the same time, RvD1 promoted the repair of articular cartilage and retarded the progression of OA in rats.
A Review of Calibration Strategies for Microscopic Parameters in Discrete Element Method
Authors: Liu Xianyang , Wang Qunwei , Wang Yongwei , Dong Qinxi 
Published: April 2023

Abstract
Discrete element method (DEM) offers a distinct advantage in addressing fracture problems due to its exemption from partial differential equations. However, the governing equations of DEM incorporate microscopic parameters that cannot be accessed via experimental methods. Parameter calibration represents the most prevalent technique currently utilized to obtain the required microscopic parameters for DEM. This article initially introduces the development history of DEM calibration, then elaborates on the governing equations of DEM and the microscopic parameters required for calibration. Next, the principles of classical DEM calibration methods are explicated in detail, alongside the validation and discussion of their properties. Lastly, this study investigates the model dependence of DEM and presents guidance for the calibration application of large-scale simulations.
Abnormal neonatal brain microstructure in gestational diabetes mellitus revealed by MRI texture analysis
Authors: Feng Zhi , Zheng Yurong , Wang Ping , Xue Liang , Yu Mingling , Deng Zhitao , Lei Xiaoping , Chen Guangxiang 
Published: April 2023

Abstract
To investigate the value of MRI texture analysis in evaluating the effect of gestational diabetes mellitus (GDM) on neonatal brain microstructure development, we retrospectively collected images of neonates undergoing head MRI scans, including GDM group (N1 =37) and healthy control group (N2 =34). MaZda texture analysis software was used to extract the texture features from different sequences images and perform dimensionality reduction, and then the texture features extracted by the lowest misjudgement rate method were imported into SPSS software for statistical analysis. In our study, we found that GDM affects the development of the microstructure of the neonatal brain, and different combinations of texture features have different recognition performance, such as different sequences, different brain regions, etc. As a consequence, texture analysis combining multiple conventional MRI sequences has a high recognition performance in revealing the abnormal development of the brain microstructure of neonates born of mothers with GDM.
Glycoprotein 1b (GP1b) protein, miR-26a-5p levels and platelet function in Alzheimer’s Disease
Authors: Ayaz Gülsel , Sordu Pelin , Hanağası Haşmet , Alaylıoğlu Merve , Gürvit Hakan , Ak Duygu Gezen , Bilgiç Başar , Dursun Erdinç , Ulutin Turgut 
Published: April 2023

Abstract
Background Alzheimer's Disease (AD) is a progressive complex neurodegenerative disorder clinical characterized by demolishing cognitive functions and behavioral abilities. Until recently, molecular mechanisms of AD have not been clarified yet. Alterations in biochemical and molecular pathways in patients suffering from AD may not only emerge in the brain but also could affect blood cells and vessels. Platelets are the blood cells that have a crucial function in the regulation of hemostasis and also play an important role in pathophysiological conditions such as neurodegenerative diseases, including AD.Methods In the current study, analyzed platelet function by optical density in 43 AD patients and 45 controls. White-Matter changes evaluated by MRI Axial FLAIR images (Fazekas scale). We measured the serum levels of vWF and GP1b proteins by ELISA and hsa-miR-26a-5p and hsa-mir24-3p by qRT-PCR analysis.Results ADP-induced platelet aggregation decreased in AD (p = 0.016). We evaluated aspirin (ASA) usage and detected that AD patients free of ASA have a significantly higher platelet function. Serum GP1b levels are a significant increase in AD (p = 0.018). The relative expression levels of hsa-miR-26a-5p are significantly low in AD (p = 0.001). A positive significant correlation was found between the relative expression values of hsa-miR-24-3p and hsa-miR-26a-5p in both control groups and AD ( p = 0.0051, r = 0.4149, 95% CI = 0.1256–0.6392; p = 0.0023, r = 0.6820, 95% CI 0.4728–0.8184)Conclusion The present study implicates that increased expression of serum GP1b and decreased relative expression levels of hsa-miR-26a-5p in AD. As a conclusion, we suggest that GP1b and hsa-miR-26a-5p essential roles of platelet function in AD.
Effects of Listening to Music on Postural Balance in Middle-Aged Women
Authors: Waer Fatma Ben , Sahli Sonia , Alexe Cristina Ioana , Man Maria Cristina , Alexe Dan Iulian , Burchel Lucian Ovidiu 
Published: April 2023

Abstract
Background The current study aimed to investigate the effect of music on both static, under different sensory manipulation, and dynamic balance in middle-aged women.Methods Twenty-four healthy women aged between 50 and 55 years (52.5 ± 2.7years; height: 1.56 ± 0.8m; weight: 78.3 ± 6.5kg) participated in this study. A stabilometric platform was used to assess their static balance by recording the mean center of pressure velocity (CoPVm) during bipedal standing with eyes open (OE) and closed (CE) on firm and foam surfaces under two auditory conditions (no music, listening to Mozart's Jupiter). The timed up and go test (TUGT) was used to assess their dynamic balance.Results Our results showed that listening to Mozart’s Jupiter significantly decreased the CoPVm values in different sensory manipulation conditions [firm surface/ EO: (p < 0.01; 95% CI: 0.27 to 2.22); firm surface/ EC: (p < 0.05; 95% CI: 0.02 to 1.97); foam surface/ EC: (p < 0.001; 95% CI: 0.48 to 2.44)], except for the foam surface/EO condition. The TUGT scores were also significantly (p < 0.001; 95% CI: 0.47 to 0.72) decreased while listing to Mozart’s symphony compared to no music condition.Conclusion We concluded that listening to Mozart’s symphony improved postural performance in healthy middle-aged women, even in challenged postural conditions. These enhancements could offer great potential for everyday functioning.
Skeletal and dentoalveolar changes after total maxillary arch distalization using the casted palatal plate vs. buccal miniscrews: A Randomized clinical trial.
Authors: Raghis Tuqa Rashad , Alsulaiman Tareq Mosleh Alfrih , Mahmoud Ghiath , Youssef Mohamed 
Published: April 2023

Abstract
Objectives: To evaluate the skeletal, dento-alveolar and soft tissue changes after skeletally anchored total maxillary arch distalization using the casted palatal plate in comparison with buccal miniscrews.
Materials & Methods: 40 adult patients (33 females and 7 males, average age 20 ± 3.1 years) with distal molar and canine relationships were treated with total maxillary arch distalization. Patients were divided according to the direct skeletal anchorage method into two equal groups; in the first group; 20 patients the casted palatal plate was used, while in the second group; 20 patients buccal miniscrews were inserted.
A total of 35 variables were measured on pre- and post-distalization lateral cephalograms. Paired t-tests were used to evaluate the differences between pre- and post-distalization in each group, and independent t-tests were used to compare treatment changes between the two groups.
Results: A significant distalization combined with intrusion and distal tipping of the maxillary first molar were observed in the plate group (4.33 mm, 1.85 mm and 3.10°, respectively). While the miniscrews group showed less amount of distalization with non-significant intrusion and distal tipping (1.88 mm, 0.8 mm and 2°, respectively). The plate group showed more decrease of SNA, ANB, B-angles and Wits-distance.
There were no significant differences between the two groups regarding sagittal, vertical and angular changes of the maxillary incisors as well as soft tissue changes.
Conclusions: Both of the casted palatal plate and buccal miniscrews might be viable as anchorage devices for total maxillary arch distalization during the treatment of Class II malocclusion patients. However, the casted plate may be considered more effective in either retraction or vertical control.
Clinical relevance: Skeletally anchored maxillary total arch distalization could be an effective treatment procedure for Class II malocclusion.
Temporal and disease-site specific transcriptional and phenotypic changes in response to neoadjuvant chemotherapy in high-grade serous ovarian cancers
Authors: Saha Sweta Sharma , Gentles Lucy , Howarth Rachel , Rundle Stuart , Ralte Angela , O'Donnell Rachel , Curtin Nicola , Drew Yvette 
Published: April 2023

Abstract
Neoadjuvant chemotherapy (NACT) has been known to induce genomic and transcriptomic alterations within tumours. Here, using transcriptome profiling along with histological analysis of pre and post NACT, we show temporal and disease site-specific differences (omentum, ovary and other sites) in high grade serous ovarian cancer (HGSOC) and their association with progression free and overall survival. We observed a significant reduction in genome instability signature score following NACT irrespective of disease site, which correlated with homologous recombination repair (HRR) function measured by RAD51 foci formation. However, increase in immuno-oncology and inflammation signatures was only observed in the omentum and not in the ovary post-NACT. DNA damage immune response (DDIR) along with HRR function were strongly associated with CD8+ T-cell infiltration within tumours. Our study provides transcriptomic and phenotypic data highlighting the heterogeneity in HGSOCs during the course of treatment and indicating how the tumour evolves in response to NACT.
Investigation of biomarker-based follow-up of anthracycline-induced cardiotoxicity in patients with breast cancer based on the latest protocol from the European Society of Cardiology guideline on cardio-oncology
Authors: Ko Seien , Shiraishi Yasuyuki , Katsumata Yoshinori , Hayashida Tetsu , Hiraide Takahiro , Kitakata Hiroki , Tsuruta Hikaru , Takahashi Maiko , Seki Tomoko , Nagayama Aiko , Kitagawa Yuko , Itabashi Yuji , Kataoka Masaharu 
Published: April 2023

Abstract
Background Anthracyclines are commonly used for the treatment of solid tumors and hematological malignancies because of their inevitable dose-dependent cardiotoxic effects. The study aimed to assess the feasibility of applying a biomarker-based surveillance strategy according to European guidelines for the early prediction of anthracycline-induced cardiotoxicity in patients with breast cancer.Methods From April 2018 to December 2021, 45 women with breast cancer (53.9 ± 11.0 years) treated with anthracycline-based regimens were evaluated for 1 year. We measured and analyzed high-sensitivity cardiac troponin T (hsTnT), B-type natriuretic peptide (BNP), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF) at baseline, and 3 and 6 months after the initiation of anthracycline-based chemotherapy. Cardiotoxicity was defined as a reduction in LVEF > 10% compared with baseline to LVEF < 53%, or a decline in GLS > 15% from baseline.Results After initiating anthracycline treatment, hsTnT levels peaked at 3 months, whereas BNP levels were the highest at 6 months. Cardiotoxicity was detected in 18 (20.0%) patients (one patient with LVEF decline), where GLS declined over time yet became significant only after 6 months. Elevated hsTnT at 3 months were significantly associated with a GLS decline at 6 months (P < 0.001, Youden index 0.009 g/mL increase from baseline; sensitivity and specificity were 100% and 80.5%, respectively). In contrast, changes in BNP were not associated with changes in LVEF or GLS. No symptomatic heart failure occurred within 1 year of chemotherapy.Conclusions Among patients with early-stage breast cancer, an increase in hsTnT at 3 months after initiation of the anthracycline-based regimen predicted a subsequent decline in GLS with high sensitivity and moderate specificity.
Complete genomes and comparative analyses of Streptomyces phages that influence secondary metabolism and sporulation
Authors: Kronheim Sarah , Solomon Ethan , Ho Louis , Glossop Michelle , Davidson Alan R. , Maxwell Karen L. 
Published: April 2023

Abstract
Bacteria in the genus Streptomyces are found ubiquitously in nature and are known for the number and diversity of specialized metabolites they produce, as well as their complex developmental lifecycle. Studies of the viruses that prey on Streptomyces, known as phages, have aided the development of tools for genetic manipulation of these bacteria, as well as contributing to a deeper understanding of Streptomyces and their behaviours in the environment. Here, we present the genomic and biological characterization of twelve Streptomyces phages. Genome analyses reveal that these phages are closely related genetically, while experimental approaches show that they have broad overlapping host ranges, infect early in the Streptomyces lifecycle, and induce secondary metabolite production and sporulation in some Streptomyces species. This work expands the group of characterized Streptomyces phages and improves our understanding of Streptomyces phage-host dynamics.
Evaluation of enamel surface roughness after orthodontic debonding and adhesive resin removal using Zirconia Burs, Tungsten Carbide Burs, and White Stone Burs: an in vitro comparative study
Authors: Thawaba Ahmed A. , Albelasy Nehal F. , Elsherbini Amira M. , Hafez Ahmad M. 
Published: April 2023

Abstract
Background The main goal of orthodontic debonding is to restore the enamel surface as closely as possible to its pretreatment condition without causing severe iatrogenic damage. This study aimed to compare the effects of different adhesive removal burs; zirconia burs, tungsten carbide burs, and white stone burs on enamel surface roughness.Materials and Methods Total sample of 72 extracted premolars was randomly divided into three equal groups (n = 24) depending on the method of adhesive removal: zirconia burs (ZB); tungsten carbide burs (TC); and white stones (WS). Before bonding, the initial surface roughness (Ra) at T0 was evaluated using a profilometer and Scanning Electron Microscopy (SEM). The metal brackets were bonded and debonded after 24 hours using a debonding plier, then the adhesive remnants were removed using the different burs. The second Ra at T1 was evaluated and the time consumed for adhesive removal was recorded in seconds. Final polishing was performed using Sof-lex discs and Sof-lex spirals, then the third Ra evaluation at T2 was performed.Results All resin removal techniques significantly increased surface roughness compared to the baseline in all groups. Ra values and SEM images concluded that the lowest surface roughness was observed in the ZB group, followed by the TC group, and WS group. Although the fastest procedure was performed with WS, followed by ZB, then TC. After polishing the Ra values significantly decreased in all groups.Conclusion zirconia burs were comparable to tungsten carbide burs and can be considered alternatives to white stones which caused severe enamel damage. The polishing step created smoother surfaces regardless of the burs used for resin removal.
Association between Child Loss and Parental Depression Among Middle-Aged and Older Adults in China
Authors: Zhang Hangkong , Jiang Wenqi , Yang Lei 
Published: April 2023

Abstract
Objectives: This study aims to examine the relationship between child loss and depression among middle-aged and older adults in China and whether this relationship changes over time.
Methods:Data were derived from the four waves of the China Health and Retirement Longitudinal Study (2011-2018). Depressive symptoms were measured repeatedly using the 10-item Centre for Epidemiologic Studies Depression Scale (CES-D-10). Child loss included the bereavement experience, number, sex, and duration. Multilevel linear regression modelling was used.
Results:CES-D-10 scores were 1.04 higher among parents who lost their children. In contrast to parents with only deceased daughters, parents with only deceased sons or both deceased sons and daughters scored 0.67 or 1.28 higher, respectively. However, the number of deceased children was not associated with depression. the depression level gradually decreased with time and significantly higher among those who lost their children within one year to four years but this association was not significant after four years.
Discussion:Child loss was associated with long-term depression among parents. However, these associations were heterogeneous for specific bereavement types. Efforts should be made to strengthen the psychological care to bereaved middle-aged and older adults.
A low-cost alternating projection approach for a continuous formulation of convex and cardinality constrained optimization
Authors: Krejic Natasa , Krulikovski Evelin H M , Raydan Marcos 
Published: April 2023

Abstract
We consider convex constrained optimization problems that also include a cardinality constraint. In general, optimization problems with cardinality constraints are difficult mathematical programs which are usually solved by global techniques from discrete optimization. We assume that the region defined by the convex constraints can be written as the intersection of a finite collection of convex sets, such that it is easy and inexpensive to project onto each one of them (e.g., boxes, hyper-planes,or half-spaces). Taking advantage of a recently developed continuous reformulation that relaxes the cardinality constraint, we propose a specialized penalty gradient projection scheme combined with alternating projection ideas to solve these problems. To illustrate the combined computational scheme, we focus on the standard mean-variance portfolio optimization problem for which we can only investin a preestablished limited number of assets. For these portfolio problems with cardinality constraints we present a numerical study on a variety of data sets involving real-world capital market indicesfrom major stock markets. On those data sets we illustrate the practical performance of the proposed scheme to produce the effective frontiers for different values of the limited number of allowed assets.
AMS Subject Classification: 90C30, 65K05, 91G10, 91G15.
Experimental and mechanism study of Cf/SiC undergoing longitudinal-torsional ultrasonic vibration assisted grinding
Authors: Wang Xiaobo , Wu Mingqiang , Song Chaosheng , Zhao Bo 
Published: April 2023

Abstract
Ceramic matrix composites (CMCs) with carbon fiber reinforcement are widely used in the aircraft industry and other important defense industries due to their superior performance. To investigate the factors affecting the grinding force and surface quality of 2.5D needled Cf/SiC material, the motion equation of abrasive particles under longitudinaltorsional ultrasonic vibration was established using kinematic analysis, and the trajectory analysis of abrasive particles was carried out using MATLAB simulation. The grinding force, surface topography, and roughness of conventional grinding (CG) and longitudinal-torsional ultrasonic vibration-assisted grinding (L-TUVAG) were analyzed and evaluated to explore the process mechanism of Cf/SiC material damage. An improved processing technique and parameters for processing were proposed. The findings show that the principal pathways for material removal during grinding are matrix breaks, interfacial debonding, fiber damage, and fractures. Grinding parameters have a significant influence on the quality of the processing surface. The surface topography steadily improves during the grinding process as the grinding wheel speed increases. However, the feed speed and grinding depth have a reverse impact. High-speed micro-grinding can significantly improve grinding efficiency and surface processing quality. L-TUVAG has a lower grinding force than CG by a factor of 16.16% to 35.82%, and the surface processing quality is correspondingly better. These discoveries enable the prediction of surface morphology and roughness characteristics of materials. And provide important technological support for improving the processing quality of CMCs.
Prediction of Histopathologic Grades of Myxofibrosarcoma with Radiomics based on Magnetic Resonance Imaging
Authors: Yao Yubin , Zhao Yan , Lu Liejing , Zhao Yongqiang , Lin Xiaokun , Xia Jianfeng , Zheng Xufeng , Shen Yi , Cai Zonghuan , Li Yangkang , Yang Zehong , Lin Daiying 
Published: April 2023

Abstract
Purpose: To develop a radiomics-based model from preoperative magnetic resonance imaging (MRI) for predicting the histopathological grades of myxofibrosarcoma.
Methods: This retrospective study included 54 patients. The tumors were classified into high-grade and low-grade myxofibrosarcoma. The tumor size, signal intensity heterogeneity, margin, and surrounding tissue were evaluated on MRI. Using the least absolute shrinkage and selection operator (LASSO) algorithms, 1037 radiomics features were obtained from fat-suppressed T2-weighted images (T2WI), and a radiomics signature was established. Using multivariable logistic regression analysis, three models were built to predict the histopathologic grade of myxofibrosarcoma. A radiomics nomogram represents the integrative model. The three models' performance was evaluated using the receiver operating characteristics (ROC) and calibration curves.
Results: The high-grade myxofibrosarcoma had greater depth (P = 0.027), more frequent heterogeneous signal intensity at T2WI (P = 0.015), and tail sign (P = 0.014) than the low-grade tumor. The area under curve (AUC) of these conventional MRI features models was 0.648, 0.656, and 0.668, respectively. Seven radiomic features were selected by LASSO to construct the radiomics signature model, with an AUC of 0.791. The AUC of the integrative model based on radiomics signature and conventional MRI features was 0.875. The integrative model's calibration curve and insignificant Hosmer-Lemeshow test statistic (P = 0.606) revealed good calibration.
Conclusion: An integrative model using radiomics signature and three conventional MRI features can preoperatively predict low- or high-grade myxofibrosarcoma.