bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective evaluation of the incidence and outcome of neutropenia in dogs with acute hemorrhagic diarrhea syndrome (2017–2022): 54 cases
Authors: Dolan Cormac , Santo‐Domingo Neus Elias 
Published: January 2025

AbstractObjectiveTo report the occurrence of neutropenia in dogs with suspected acute hemorrhagic diarrhea syndrome (AHDS) and to assess its association with survival. Secondary objectives were to assess whether neutropenia was associated with length of hospitalization, fulfillment of systemic inflammatory response syndrome (SIRS) criteria, and whether SIRS status was associated with survival. Finally, the association of antimicrobial use with neutropenia, SIRS status, and survival was evaluated.DesignSingle‐center, retrospective study from the medical records of dogs diagnosed with AHDS between 2017 and 2022.SettingPrivate referral hospital.AnimalsFifty‐four dogs with suspected AHDS referred to the Emergency and Critical Care specialist service.InterventionsNone.Measurements and Main ResultsOf 54 dogs, 28 (52%) presented with or developed neutropenia during their treatment course. Overall, 9 (17%) dogs were nonsurvivors. A total of 8 of 28 (29%) dogs with neutropenia were nonsurvivors, while only 1 of 26 (4%) dogs with a normal neutrophil count was a nonsurvivor (P = 0.025). Upon hospital admission, neutropenic dogs were significantly more likely to fulfill SIRS criteria than nonneutropenic dogs (P = 0.0096). There was no difference in mortality between SIRS‐positive (fulfilling ≥2 SIRS criteria) and SIRS‐negative (fulfilling <2 SIRS criteria) dogs (P = 0.14). There was no difference in the median length of hospitalization between neutropenic and nonneutropenic dogs (P = 0.49).ConclusionsThe incidence of neutropenia is high in this population of dogs presenting with AHDS. In this retrospective study, neutropenia was significantly associated with an increased risk of nonsurvival and an increased likelihood of fulfilling SIRS criteria; however, a fulfillment of SIRS criteria could not be used to predict survival. Neutropenia in dogs with AHDS was not associated with an increased length of hospitalization.
Validity of Lower-Extremity Strength Between Push- and Pull-Based Handheld Dynamometers: A Technical Report
Authors: Glaviano Neal R. , Zuk Emma F. , Sheldon Lauren , DiStefano Michael , Devaney Laurie 
Published: January 2025

Context: Handheld dynamometers provide clinicians an objective measure of lower-extremity force production at the hip and knee. While push-based dynamometers are common in clinical practice, they can be associated with patient discomfort, and standardization of methods is challenging when patient forces can exceed the ability of the rater. Development of novel, pull-based dynamometers allow for better patient comfort, but validity between dynamometers must be established before integration into clinical practice. Therefore, the purpose of this study was to compare measurement of lower-extremity force between push- and pull-based handheld dynamometers. Design: Descriptive laboratory study. Methods: Twenty-one healthy triathletes performed isometric hip abduction, hip external rotation, and knee extension testing against 2 separate handheld dynamometers. Pearson product correlations were calculated for the relationship between devices, while Bland–Altman plots were used to measure agreement with limit of agreement to assess systematic bias. Results: Correlations between devices were strong for hip abduction and knee extension (r = .743–.767, P < .001) and moderate for hip external rotation (r = .429, P = .052). Additionally, there was good agreement between the 2 devices, with acceptable limits of agreement across the 3 force tasks. The pull-based dynamometer resulted in greater torque values for knee-extension and hip external rotation, with a mean difference of −0.37 and −0.19 N·m/kg, but there was no difference in hip abduction with a mean difference of 0.03 N·m/kg. Conclusion: The results demonstrate that pull-based dynamometers are an acceptable alternative to push-based dynamometers for hip abduction and knee extension, but some caution may exist for hip external rotation. Clinicians should be aware of differences in lower-extremity force across multiple handheld dynamometers when assessing muscle function in practice.
Plasma transfusions in neonatal intensive care units: a prospective observational study
Authors: Houben Nina A M , Fustolo-Gunnink Suzanne , Fijnvandraat Karin , Caram-Deelder Camila , Aguar Carrascosa Marta , Beuchée Alain , Brække Kristin , Cardona Francesco Stefano , Debeer Anne , Domingues Sara , Ghirardello Stefano , Grizelj Ruža , Hadžimuratović Emina , Heiring Christian , Lozar Krivec Jana , Maly Jan , Matasova Katarina , Moore Carmel Maria , Muehlbacher Tobias , Szabo Miklos , Szczapa Tomasz , Zaharie Gabriela , de Jager Justine , Reibel-Georgi Nora Johanna , New Helen V , Stanworth Simon J , Deschmann Emöke , Roehr Charles C , Dame Christof , le Cessie Saskia , van der Bom Johanna G , Lopriore Enrico 
Published: January 2025

ObjectiveDespite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices in neonatal intensive care units (NICUs) is poorly understood, therefore, we aimed to describe neonatal plasma transfusion practice in Europe.DesignProspective observational study.Setting64 NICUs in 22 European countries, with a 6-week study period per centre between September 2022 and August 2023.PatientsPreterm infants born below 32 weeks of gestational age.InterventionsAdmission to the NICU.Main outcome measuresPlasma transfusion prevalence, cumulative incidence, indications, transfusion volumes and infusion rates and adverse effects.ResultsA total of 92 of 1143 infants included (8.0%) received plasma during the study period, collectively receiving 177 transfusions. Overall prevalence was 0.3 plasma transfusion days per 100 admission days, and rates varied substantially across Europe. By day 28 of life, 13.5% (95% CI 10.0% to 16.9%) of infants received at least one plasma transfusion, accounted for competing risks of death or discharge. Transfusions were given for a broad range of indications, including active bleeding (29.4%), abnormal coagulation screen results (23.7%) and volume replacement/hypotension (21.5%). Transfusion volumes and infusion rates varied significantly; the most common volume was 15 mL/kg (range: 5–30 mL/kg) and the most common duration was 2 hours (range: 30 min to 6 hours).ConclusionsWe found wide variation in plasma transfusion practices in Europe, highlighting the need for evidence to inform neonatologists in daily practice and guidelines, in particular for non-bleeding indications.Trial registration numberISRCTN17267090.
Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders
Authors: Holmberg Anna , Pol-Fuster Josep , Kuja-Halkola Ralf , Larsson Henrik , Lichtenstein Paul , Chang Zheng , D’Onofrio Brian M , Brikell Isabell , Sidorchuk Anna , Isomura Kayoko , Crowley James J , Martinsson Lina , Rück Christian , Mataix-Cols David , Fernández de la Cruz Lorena 
Published: January 2025

BackgroundObsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders.MethodsWe identified 6 049 717 individuals born in Sweden between 1950 and 2008, including 50 212 individuals with OCD, and followed them up to 2020. These individuals were linked to their mothers, fathers, full siblings, maternal and paternal half siblings, aunts, uncles and cousins. We estimated the risk of cardiovascular diseases (CVD) and metabolic disorders (including obesity, type 2 diabetes and hyperlipidaemia), comparing the relatives of probands with and without OCD. Cox proportional hazards regression models, incorporating time-varying exposures, estimated HRs.ResultsOCD was associated with an increased risk of CVD (HR 1.47; 95% CI 1.43 to 1.51), obesity (HR 1.69; 95% CI 1.63 to 1.74), type 2 diabetes (HR 2.01; 95% CI 1.90 to 2.12) and hyperlipidaemia (HR 1.42; 95% CI 1.33 to 1.52). The relatives of probands with OCD exhibited small increased risks of CVD (HRs from 1.01 to 1.11) and obesity (HRs from 1.03 to 1.20). Slightly increased risks for type 2 diabetes were observed in mothers (HR 1.11; 95% CI 1.07 to 1.15) and full siblings (HR 1.12; 95% CI 1.05 to 1.20), while for hyperlipidaemia it was only observed in mothers (HR 1.06; 95% CI 1.02 to 1.10).ConclusionsOur results do not support a major contribution of familial factors to the association between OCD and cardiometabolic disorders, suggesting a more prominent role of unique environmental factors.
Qualitative systematic review on the lived experience of functional neurological disorder
Authors: Szasz Andrea , Korner Anthony , McLean Loyola 
Published: January 2025

ObjectivesFunctional neurological disorder (FND) is a complex disorder, recently attracting much research into aetiology and treatment. However, there is limited research on the patient’s lived experience. This paper addresses this gap to ask: ‘What is the subjective life experience of adult patients living with FND?’MethodsFrom 1980 to 2020, Medline, PsycInfo, Scopus, Science Direct, PubMed, CINAHL and Embase were searched for English language qualitative adult research. The disciplines used general medicine, psychiatry, physiotherapy, nursing, neurology, psychosomatic medicine and occupational therapy. The qualitative literature search included book chapters, theses, fellowship reports and conference articles as well as peer-reviewed scientific journals.The Critical Appraisal Skills Programme tool was used to assess 33 papers, with eight papers included in the final synthesis. Nine additional papers, suggested during review, were evaluated but excluded from synthesis, though incorporated elsewhere in the paper. Two authors used an integrative immersion approach to identify the literature’s main themes using line-by-line and top-down methods.ResultsEight main themes were identified: lost, body–mind dualism, preceding stressful events, relatedness, stigma, the battle or fight, the burden and losses of the illness and trust versus mistrust. From these emerged a central overarching theme of relationally regulated selves, which posits the essence of the lived experience of FND as responding to stressful experiences within a relational, regulatory context.ConclusionsThe prevalent themes give valuable insight into the lived experience of FND and the impact of stressors, past and present, and the relational environment in the development of and recovery from the disorder. Further research is needed to support the formulation of the patient experience and cocreated recovery pathways.
Impact of hospital readmission site on outcomes in acute ischemic stroke patients undergoing mechanical thrombectomy: a nationwide analysis
Authors: Wu Moxin , Shu Liqi , Mawad Mariel , Nguyen Thanh N , Siegler James E , Luo Anqi , Guo Xiaofan , Strelecky Lukas , Xiao Han , Furie Karen , Yaghi Shadi 
Published: January 2025

BackgroundMechanical thrombectomy (MT) significantly improves outcomes in patients with acute ischemic stroke due to large vessel occlusion. There is limited understanding of how the site of hospital readmission after MT influences patient outcomes. Addressing this gap may be important for optimizing post-MT care and improving long-term outcomes for stroke patients.MethodsWe conducted a retrospective cohort analysis using data from the Nationwide Readmissions Database, focusing on acute ischemic stroke patients who underwent MT between 2016 and 2019. Multivariable Cox regression and Fine and Gray competing risks models were used to assess the impact of readmission site on patient outcomes, including mortality and the likelihood of discharge to home.ResultsThe analysis included 18 330 patients readmitted within 90 days post-MT, with 63.7% readmitted to index hospitals and 36.3% to non-index hospitals. Readmission to the index hospital was not significantly associated with mortality but was linked to a higher likelihood of discharge to home (subdistributed HR 1.22, 95% CI 1.13 to 1.32, P<0.001), a lower likelihood of longer hospital stay (OR 0.81, 95% CI 0.72 to 0.90, P<0.001), and lower hospital cost (β = −3345.25, 95% CI −5786.46 to −904.04, P=0.007).ConclusionThis nationwide analysis suggests that for acute ischemic stroke patients treated with MT, readmission to index hospitals within 90 days is associated with a higher likelihood of home discharge, shorter length of stay, and lower hospital cost. Further research is warranted to better understand the underlying causes of these disparities and to enhance continuity of care for this vulnerable patient population.
One way or another, you are not going to fit: trans and gender diverse people’s perspectives on sexual health services in the United Kingdom
Authors: Witney Tom , Rait Greta , Saunders John , Hobbs Lorna , Mitchell Laura , Stewart Jay , McDonagh Lorraine K 
Published: January 2025

ObjectivesTrans and/or gender diverse (T/GD) people in the UK are less likely to access sexual health services (SHS) than cisgender people and are more likely to report negative experiences. The British Association for Sexual Health and HIV (BASHH) developed expert recommendations for T/GD-inclusive SHS, but these lack service user perspectives. This study addressed this gap by asking T/GD people how SHS could be T/GD-inclusive.MethodsSemistructured interviews (n=33) and focus groups (n=26) were conducted with T/GD people aged 17–71 years old recruited through community organisations and social media, exploring experiences of SHS and inclusivity. Study design, materials and analysis were informed by T/GD people and an advisory committee of charities and sexual health clinicians. Data were analysed using thematic analysis, managed using NVivo.ResultsParticipants often expected that SHS were not set up for T/GD people. This was reinforced by poor experiences in other healthcare settings and the lack of information on NHS websites. Some participants had been denied care because they were ‘too complex’. Participants wanted to know that SHS had engaged with the needs of T/GD people and looked for hallmarks of inclusivity, such as Trans Pride flags in reception areas. Some participants wanted specialist T/GD services, but others preferred to access general SHS. Staff attitudes were a key factor underpinning inclusivity. Anticipating having their identity questioned or needs dismissed, participants sought kindness and openness. Although the needs of T/GD people are diverse and different from cisgender service users, participants stressed that SHS staff already had the skills to deliver sensitive person-centred care and emphasised the value of inclusive SHS.ConclusionThese findings provide insight into what a sample of T/GD people in the UK consider important for T/GD-inclusive SHS. Participants’ suggestions align with and reinforce BASHH expert recommendations. Importantly, they highlight the need for ongoing engagement to deliver T/GD-inclusive SHS.
Financial toxicity and firearm injury: exploring financial needs of participants in a hospital-based violence intervention program
Authors: Reyes Ana M , McKenzie Carlene , Scott Meghan , Haggerty Christopher R , Valenzuela Julie Y 
Published: January 2025

BackgroundFinancial toxicity refers to financial hardship experienced because of illness or injury. Poverty is a known driver of community violence, but financial toxicity has not been studied in firearm violence survivors. The objective of our study was to explore the financial needs of firearm violence survivors enrolled in a hospital-based violence intervention program (HVIP). We hypothesized that survivors would report numerous financial needs.MethodsThis was a mixed-methods, retrospective study of firearm violence survivors enrolled in the Miami-Dade County HVIP from 2022 to 2023. Patients were eligible for enrollment if they were injured in shooting incidents that occurred in Miami-Dade police districts with high rates of group violence or gang-related violence. Social worker intake and longitudinal case records were reviewed. A qualitative thematic analysis of social worker notes was performed. Quantitative data were analyzed with descriptive statistics and χ2tests for association.Results103 patients were enrolled in the program. The median age was 27 years. The majority of patients were black (82.5%) and male (83.5%). More patients were insured (59.2%) than uninsured (40.8%). Thematic analysis revealed 10 distinct financial needs, including assistance with victim crime compensation (75.7% of patients), medical bills (35.0%), wage loss (22.3%), insurance applications (14.6%), burial (13.6%), and emergency relocation (12.6%). Overall, financial needs were identified for 94 (91.3%) patients: 91 (88.3%) at initial program intake and 3 additional patients (2.9%) during longitudinal case management.ConclusionsSurvivors of firearm violence experience financial challenges after injury. Thus, financial support and assessment for financial toxicity should be included in firearm violence survivorship programs. Future investigations should use validated measures to study the financial toxicity of firearm violence survivors longitudinally.
Randomized clinical trial of peer integrated collaborative care intervention after physical injury
Authors: Zatzick Douglas F , Bulger Eileen M , Thomas Peter , Engstrom Allison , Iles-Shih Matt , Russo Joan , Wang Jin , Shoyer Jake , Conde Cristina , Abu Khadija , Birk Navneet , Palinkas Lawrence , Heagerty Patrick , Whiteside Lauren K , Ryan Paige , Knutzen Tanya , Maier Ronald 
Published: January 2025

ObjectivesThe goal of the current study was to assess the effectiveness of a peer integrated collaborative care intervention for postinjury outcomes.MethodsInjury survivors ≥18 years of age were screened for post-traumatic stress disorder (PTSD) symptoms and severe postinjury concerns; screen-positive patients were randomized to the intervention versus enhanced usual care control conditions. The collaborative care intervention included peer support and care management. The intervention also included evidence-based pharmacotherapy and psychotherapeutic elements targeting PTSD. The COVID-19 pandemic interrupted recruitment between March and June 2020; in response to the COVID-19 pandemic, the peer component of the intervention went from in-person to virtual delivery. The primary outcomes were PTSD symptoms assessed with the Diagnostic and Statistical Manual of Mental Disorders fourth edition PTSD checklist, any severe postinjury concerns, and emergency department/inpatient utilization followed over the 12 months postinjury. Secondary outcomes included patient satisfaction with emotional healthcare.ResultsA total of 450 patients were randomized to the intervention (n=225) and control (n=225) conditions; 124 patients (28%) were recruited and completed all study assessments prior to the onset of the COVID-19 pandemic, while 326 patients (72%) were recruited after and/or had one or more study follow-ups occur postpandemic onset. Mixed model regression revealed no statistically significant comparisons for any of the primary outcomes. In exploratory models that examined the impact of COVID-19, significantly improved PTSD symptoms were present at 3 months pre-COVID-19 relative to post-COVID-19. Intervention patients consistently demonstrated higher satisfaction with emotional aspects of healthcare (F(5,1652)=2.87, p=0.01).ConclusionsThe intervention demonstrated no significant improvements in primary outcomes in the intent-to-treat sample. The peer integrated collaborative care intervention contributed to higher patient satisfaction with the emotional aspects of healthcare.Level of evidenceLevel II, randomized clinical trial.Trial registration numberNCT03569878.
Improved background modeling for dark matter search with COSINE-100
Authors:   (COSINE-100 Collaboration), Yu G. H. , Carlin N. , Cho J. Y. , Choi J. J. , Choi S. , Ezeribe A. C. , França L. E. , Ha C. , Hahn I. S. , Hollick S. J. , Jeon E. J. , Joo H. W. , Kang W. G. , Kauer M. , Kim B. H. , Kim H. J. , Kim J. , Kim K. W. , Kim S. H. , Kim S. K. , Kim W. K. , Kim Y. D. , Kim Y. H. , Ko Y. J. , Lee D. H. , Lee E. K. , Lee H. , Lee H. S. , Lee H. Y. , Lee I. S. , Lee J. , Lee J. Y. , Lee M. H. , Lee S. H. , Lee S. M. , Lee Y. J. , Leonard D. S. , Luan N. T. , Manzato B. B. , Maruyama R. H. , Neal R. J. , Olsen S. L. , Park B. J. , Park H. K. , Park H. S. , Park J. C. , Park K. S. , Park S. D. , Pitta R. L. C. , Prihtiadi H. , Ra S. J. , Rott C. , Shin K. A. , Cavalcante D. F. F. S. , Son M. K. , Spooner N. J. C. , Truc L. T. , Yang L. 
Published: January 2025

Abstract
COSINE-100 aims to conclusively test the claimed dark matter annual modulation signal detected by DAMA/LIBRA collaboration. DAMA/LIBRA has released updated analysis results by lowering the energy threshold to 0.75 keV through various upgrades. They have consistently claimed to have observed an annual modulation. In COSINE-100, it is crucial to lower the energy threshold for a direct comparison with DAMA/LIBRA, which also enhances the sensitivity of the search for low-mass dark matter, enabling COSINE-100 to explore this area. Therefore, it is essential to have a precise and quantitative understanding of the background spectrum across all energy ranges. This study expands the background modeling from 0.7 to 4000 keV using 2.82 years of COSINE-100 data. The modeling has been improved to describe the background spectrum across all energy ranges accurately. Assessments of the background spectrum are presented, considering the nonproportionality of NaI(Tl) crystals at both low and high energies and the characteristic X-rays produced by the interaction of external backgrounds with materials such as copper. Additionally, constraints on the fit parameters obtained from the alpha spectrum modeling fit are integrated into this model. These improvements are detailed in the paper.
The ALICE 3 detector concept for LHC Runs 5 and 6 and its physics performance
Authors: Vértesi Róbert 
Published: January 2025

Abstract
The LHC Run 5 and 6 data taking phases will deliver unprecedented luminosity in high-energy proton-proton and heavy-ion collisions, enabling insightful advancements in understanding quantum chromodynamics (QCD), and, in particular, the quark-gluon plasma (QGP). The ALICE Collaboration proposes ALICE 3, a next-generation experiment optimized for these future LHC operations. ALICE 3 will feature a cutting edge pixel-based tracking system with broad pseudorapidity coverage (|

$$\eta$$

η

|<4), supplemented by advanced particle identification systems. These include silicon time-of-flight layers, a ring-imaging Cherenkov detector, a dedicated muon identification system, and an electromagnetic calorimeter. A novel retractable vertex detector inside the beam pipe will achieve a track pointing resolution lower than 10 microns for transverse momenta above 200 MeV/c. ALICE 3 aims to conduct innovative measurements of QGP properties and extend the frontiers of our knowledge in QCD. The detailed study of thermal and dynamical properties of the QGP will be made possible by measuring low-transverse-momentum heavy-flavour production, including beauty hadrons, multi-charm baryons, and charm-charm correlations. Precise multi-differential measurements of dielectron emission will shed light on chiral-symmetry restoration and the time-evolution of QGP temperature. In addition to QGP studies, ALICE 3 will uniquely address the physics of hadronic phase, exploring charm meson interaction potentials via femtoscopy, and searching for exotic nuclei with charm quarks. This contribution presents the detector concept, expected physics performance, and the current status of the research and development efforts.