bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESTUDIO DE LAS POLÍTICAS CURRICULARES
Authors: Garduño José María García , Fiad Silvia Miracy Pastro 
Published: April 2023

El propósito de este trabajo fue analizar los antecedentes y desarrollo del campo de estudio de las políticas curriculares, sus definiciones y delimitaciones, asi como analizar las propuestas de análisis de políticas curriculares basadas en el ciclo clásico de políticas ideado por Harold Laswell. El trabajo traza la evolución y desarrollo de las políticas curriculares desde LA aparición del término a mediados de los años 50 del siglo pasado. Asimismo, enfatiza la importancia de adoptar definiciones más precisas que consideren los diferentes tipos de políticas curriculares. El trabajo concluye con el análisis de enfoques análisis de políticas curriculares que están basados en el ciclo de políticas los cuales toman como principal unidad de análisis los actores involucrados y que estas propuestas pueden complementar otros enfoques que se emplean en el estudio de las políticas curriculares.
MicroRNA expression profile in isolated circulating tumor cells in colorectal cancer
Authors: Kit O. I. , Novikova I. A. , Timoshkina N. N. , Gvaldin D. Yu. , Pushkin A. A. , Kaimakchi O. Yu. , Maslov A. A. , Shaposhnikov A. V. 
Published: April 2023

Introduction. Colorectal cancer is a frequently diagnosed disease being in the third place among oncological diseases both in incidence and mortality. Currently, researchers focus on development of more accessible and reliable biomarkers of colorectal cancer to overcome the problems in diagnosis and progression prognosis of this pathology.Aim. To investigate characteristics of microRNA expression in circulating tumor cells (CTC) of patients with colorectal cancer. Materials and methods. The study included blood samples from 299 patients with colon cancer, stages II (T3–4N0M0), III (T1–4N1–2M0) and IV (T1–4N0–2M1). Circulating tumor cells were identified using EpCAM marker detection system. Relative expression of hsa-let-7i-5p, hsa-miR-126-5p, hsa-miR-143-3p, hsa-miR-21-5p, hsa-miR-25-3p, hsa-miR-26a-5p, hsa-miR-92a-3p micro RNA in CTC was measured using polymerase chain reaction.Results. Positive CTC status was observed in 188 (62.9 %) of 299 patients, negative in 111 (37.1 %). In the patient group with pT1–2 tumors, the majority of patients did not have CTC (53.3 %). In other patients with pT1–2 disease, the number of CTC was 1.2 and 4.4 times lower than in patients with pT3 and pT4 disease, respectively. In pT4, 1–3 CTC were found 2.7 and 1.7 times more frequently, 3 CTC 1.4 times more frequently than in pT1–2 and pT3, respectively (p ≤0.05). Presence of metastatic lesions increases the probability of CTC detection by the factor of 2.1: in metastases, >3 CTC were observed 60.1 times more frequently than in M0 (p ≤0.05). Expression of hsa-miR-143-3p and hsa-miR-26a-5p microRNA in CTC of patients with stage III colorectal cancer was respectively 2.5 and 5 times lower than in patients with stage II disease (p <0.05) and expression of hsa-miR-21-5p and hsa-miR-92a-3p microRNA was respectively 3.2 and 3 times higher (p <0.05). In CTC of patients with stage IV colorectal cancer, the relative level of expression of hsa-miR-143-3p and hsa-miR-26a-5p was respectively 4.6 and 5.3 times lower (p <0.05) compared to the level of expression in stage II disease, and hsa-miR-126-5p, hsa-miR-21-5p, hsa-miR-25-3p and hsa-miR-92a-3p expression levels were respectively 2.6, 4.6, 2.6 and 5.0 times higher (p<0.05) (statistically significant results).Conclusion. The level of microRNA expression in CTC can be used for differential diagnosis of regional and distant metastases.
Genetic Diversity and Relationship of Durian (Durio spp.) Germplasm Based on the Internal Transcribed Spacer (ITS) Region: In Silico Analysis
Authors: Mursyidin Dindin Hidayatul , Makruf Muhammad Irfan , Aliannur Nico 
Published: April 2023

Durian (Durio spp.) is a germplasm with a relatively high species diversity, with an estimated 27 species worldwide. However, the existence of several species has been threatened. This study aimed to reconstruct the DNA barcode of the durian and its relatives (Durio spp.) and analyze the genetic diversity and its relationship based on the internal transcribed spacer (ITS) region. Sixteen sequences of durians ITS were collected from GenBank (NCBI) and analyzed in silico using the BLAST, MultAlin, and MEGA-X software, then reconstructed phylogenetically by the UPGMA and Maximum Likelihood methods. The results show that the ITS region of Durio spp. has a base length of about 702 bp, where several mutations occur, substitution (transversion and transition) and indel (insertion and deletion). At the nucleotide level, this germplasm shows a relatively high diversity of 0.065. The cluster analyses (UPGMA and Maximum Likelihood) can separate this germplasm into four clusters and five main clades, respectively. In this study, D. zibethinus, the most popular species in the Durio genus, is closely related to D. lowianus and far from D. griffithii. This information is beneficial as reference data to support durian conservation and breeding programs, locally and globally, especially in Indonesia.
Evaluation of role of serum prolactin & ki-67 in different stages of breast cancer
Authors: Sagar Pallavi , Kumar Sandeep , Krishna Neha Mala , Kumar Manish , Keshari J R 
Published: April 2023

Breast cancer is the most frequent cancer among women. Prolactin (PRL) is a hormone secreted from anterior pituitary gland which stimulates cell proliferation, survival of cancer cells, its migration, invasion and angiogenesis. Breast cancer is strongly associated with raised plasma Prolactin level (PRL). The Prolactin behaves like Growth Hormone and its actions by the growth-promoting JAK/STAT pathway suggests its tumor-promoting effects.Ki-67 a Nuclear Protein is highest in Luminal B, Ki67 are not related to age but is correlated with tumor size. Fraction of Ki-67 positive tumor cells correlates with the clinical course of cancer cells. Hence, Ki- 67 can be an effective target in cancer therapy. Ki-67% and Serum Prolactin level may be considered a valuable biomarker in breast cancer patients and be used in treatment, follow-up and Prognosis.
Emotions and Consumption: Media Representations in the Discourse of Some British and Polish News Websites
Authors: Duda Aneta 
Published: April 2023

The purpose of the study was to test the hypothesis referring to the dominant ways of portraying consumption on some Polish and British websites during a pandemic—either as a social practice with huge chances to consume less or as a significant factor which affects economic growth. On the one hand, the circumstances surrounding the coronavirus could provide an opportunity to “fast-forward” some of the changes required. On the other hand, journalists recommend a quick return to pre-COVID-19 consumption lives, a stimulation of consumption in order to save the national economy.
The article uses a framing analysis to examine consumption-related texts from two most-read, opinion-forming Polish and British websites—polityka.pl and bbc.com. The framing analysis focuses on the practices involved in the shaping of public discourse; it responds to the need for research into the social significance of consumption.
It turns out that the two frames of consumption as 1) overconsumption in terms of the need of change in consumer attitudes and behaviour and 2) a factor that affects economic growth are not the dominant ways of portraying this phenomenon during a pandemic. The everyday consumption frame was found to be used more often than the aforementioned frames.
Biodiversity-food trade-offs when agricultural land is spared from production
Authors: Palmer Charles , Groom Ben , Sileci Lorenzo , Langton Steve 
Published: April 2023

Abstract
The Kunming-Montreal Global Biodiversity Framework proposes to address biodiversity decline by expanding areas under conservation. Biodiversity conservation in agricultural landscapes, the world’s predominant land use, could involve sparing, or setting aside, agricultural land from production, implying biodiversity-food trade-offs. Employing bird species and agricultural data, we undertake a novel empirical analysis of such trade-offs on a set-aside scheme implemented in England between 1992-2007. Expanding set-aside increases bird species abundance and richness by, respectively, 1.2-2.1% and 0.7-0.9%, but has no impact on diversity (Shannon-Wiener index). These effects are discontinuous, subject to thresholds in set-aside areas. A minimum 3% of agricultural land set aside is required for a positive effect on biodiversity while 13% of agricultural land generates a 15-25% and 30-35% increase in abundance and richness, respectively. Estimates of short- and long-run effects show that impacts are larger in the long-run. Expanding set-aside is also associated with a 10-17% decline in cereal output, with weak evidence of an attenuating land-sparing effect on yields. Our results suggest that although biodiversity-food trade-offs are likely in high-yield agricultural landscapes, such as those in England, the risk of a reduction in food supply could be minimised in settings where there is still scope for intensification.
The predictive value of neurally adjusted ventilatory assist indexes for the outcome of patients with severe hemorrhagic stroke
Authors: Tang Yun , Yu Tao , Niu Sha , Wang Kui , Wu Nianlong , Wang Guiliang , Fan Zhen , Yao Lin 
Published: April 2023

Abstract
Objective: This study assessed the predictive value of electrical activity of the diaphragm (EAdi) and the EAdi-derived monitoring index in the outcome of patients with severe hemorrhagic stroke. Methods: Ninety patients with severe hemorrhagic stroke were admitted to the neurosurgery intensive care unit of Yijishan Hospital from April 2019 to June 2021 and were divided into the good outcome group (Glasgow Outcome Scale [GOS] ≥4) and poor outcome group [GOS]≤3). The receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to evaluate prediction accuracy. Results: EAdi, neuro-ventilatory efficiency (NVE), and neuro-muscular efficiency (NME) in patients with good outcome were significantly higher than those in patients with poor outcome (4.707 µV vs 2.80 µV, P < 0.001; 141.85 ml/µV vs 66.01 ml/µV, P = 0.000; 2.57 cm H2O/µV vs 1.37 cm H2O/µV, P = 0.000). The area under the ROC curve for the EAdi score was 0.719, with sensitivity of 69.70% and specificity of 68.42% when EAdi was 3.6 µV. The AUC for NVE score was 0.793, with sensitivity of 75.76% and specificity of 77.19% when the NVE value was 95.32 ml/µV. The AUC for NME score was 0.792, with sensitivity of 69.70% and specificity of 78.95% when the NME value was 2.06 H2O/µV. The 6-month survival time of patients with higher EAdi, NVE, and NME was significantly longer than that of patients with lower EAdi, NVE, and NME. Conclusion: EAdi, NVE, and NME can be used as indices for predicting the outcome of patients with severe hemorrhagic stroke.
Trial registration: No.ChiCTR1900022861. Registered April 28, 2016, http:// www.chictr.org.cn
Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate
Authors: Vardi-Yaacov Oriya , Yaacov Adar , Rosenberg Shai , Simon Itamar 
Published: April 2023

Abstract
Cancer somatic mutations are the product of multiple mutational and repair processes, both of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but different processes can affect this association. Systematic analysis of the mutational landscape of 2,787 tumors from 32 tumor types revealed that approximately one third of the tumor samples show weak association between replication timing and mutation rate. Further analyses revealed that those samples have unique mutational signatures and are enriched with mutations in genes involved in DNA replication, DNA repair and chromatin structure. Surprisingly, analysis of differentially expressed genes between weak and strong RT-MR association groups revealed that tumors with weak association are enriched with genes associated with cell-cell communication and the immune system, suggesting a non-autonomous response to DNA damage.
Anti-viral chimeric protein RetroMAD1™ potently block SARS-CoV-2 viral entry and propagation
Authors: Chan Lee-Chin , Yassim Aini Syahida Mat , Leow Thean Chor , Sabri Suriana , Yahaya Radin Shafierul Radin , Bakar Awang Muhammad Sagaf Abu 
Published: April 2023

Abstract
COVID-19 is a disease caused by the highly transmissible and pathogenic SARS-CoV-2 virus. Since its first case was documented in 2019, it has rapidly widespread and has caused millions of deaths worldwide. Many intervention strategies targeting these proteins have been developed. However, frequently mutation of SARS-CoV-2 poses a challenge to the effectiveness of current treatments. Therefore, it is critical to develop new therapeutic drugs against this disease. In this present study, in silico approach was used to study the interaction between RetroMAD1™and SARS-CoV-2 proteins including Spike proteins (S), 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). The interaction of these viral proteins and RetroMAD1™ was performed through HDOCK server and visualised using PyMOL. Docking results revealed that all the complexes of SARS-CoV-2 proteins binding with RetroMAD1™ have relatively high docking scores. The binding energy of RetroMAD1™ complexes with SARS-CoV-2 S, 3CLpro, PLpro were − 15, -12.3 and − 15.4, respectively. RetroMAD1™antiviral efficiency and cytotoxicity was also evaluated using EpiAirway™ Model. In vitro validation of viral inhibitory effect of RetroMAD1™was performed with 3CLpro Inhibition Assay. The outcome showed that RetroMAD1™ represents a potential drug candidate against SARS-CoV-2 for its promising viral inhibitory effect.
SILAR-Based Synthesis of Cd-Doped CuS Nanocrystalline Thin Films and their Photocatalytic Activity
Authors: Bhosle Pankaj P. , Nimbalkar Siddharth D. , Jare Sandeep K. , Pandit Vishal A. , Rode Mahadev N. 
Published: April 2023

Abstract
The Successive Ionic Layer Adsorption and Reaction (SILAR) approach was used to fabricate Cd doped CuS nanocrystalline thin films. On the optical, structural, morphological, and electronic properties of Cd doped CuS films, the influence of a 3% Cd doping concentration was investigated. The cubic phase crystal structure of the Cd doped CuS thin was revealed by XRD measurements to be polycrystalline. The bonding of the CuS semiconductor material was verified by FTIR spectra, which also displayed the emission bands of the films. The surface morphology of the produced films changes with the concentration of Cd doping, according to the FESEM data. In the UV visible spectroscopy, a blue shift in the optical band gap was identified. Under the irradiation of sunshine, the photocatalytic activity of Rhodamine B was investigated. The degradation efficiency increased nearly 97% as Cd concentration increased.
Nitrate radicals suppress biogenic new particle formation from monoterpene oxidation
Authors: Li Dandan , Huang Wei , Wang Dongyu , Wang Mingyi , Thornton Joel , Caudillo Lucía , Rörup Birte , Marten Ruby , Scholz Wiebke , Finkenzeller Henning , Marie Guillaume , Bell David , Brasseur Zoé , Curtius Joachim , Dada Lubna , Duplissy Jonathan , Gong Xianda , Hansel Armin , He Xu-cheng , Hofbauer Victoria , Junninen Heikki , Krechmer Jordan E. , Kurten Andreas , Lamkaddam Houssni , LEHTIPALO Katrianne , Lopez Brandon , Ma Yingge , Mahfouz Naser , Manninen Hanna E. , Mentler Bernhard , Perrier Sebastien , Petäjä Tuukka , Pfeifer Joschka , Philippov Maxim , Schervish Meredith , Schobesberger Siegfried , Shen Jiali , Surdu Mihnea , Tomaz Sophie , Volkamer Rainer , Wang Xinke , Weber Stefan , Welti André , Worsnop Douglas , wu yusheng , Yan Chao , Zauner-Wieczorek Marcel , Kulmala Markku , Kirkby Jasper , Donahue Neil , George Christian , El-Haddad Imad , Bianchi Federico , Riva Matthieu 
Published: April 2023

Abstract
Highly oxygenated organic molecules (HOMs) are a major source of new particles affecting Earth’s climate1,2. HOM production from the oxidation of volatile organic compounds (VOCs) occurs during both day and night, and can lead to new particle formation (NPF)3,4. However, NPF involving organic vapors has been reported much more often during daytime3-6 than during nighttime7,8. Here, we show that the nitrate radicals (NO3) - which arise predominantly at night – inhibit NPF during the oxidation of monoterpenes based on three lines of observational evidence: NPF experiments in the CLOUD chamber at CERN; radical chemistry experiments using an oxidation flow reactor; and field observations in a wetland that occasionally exhibits nocturnal NPF. Nitrooxy-peroxy radicals formed from NO3 chemistry suppress the production of ultra-low volatility organic compounds (ULVOCs) responsible for biogenic NPF, which are covalently bound RO2 dimer association products. The ULVOC yield of α-pinene in the presence of NO3 is one-fifth of that resulting from ozone chemistry alone. Even trace amounts of NO3 radicals, at sub parts per trillion level, suppress the NPF rate by a factor of 4. Ambient observations further confirm that when NO3 chemistry is involved, monoterpene NPF is completely turned off. Our results explain the frequent absence of nocturnal biogenic NPF in monoterpene-rich environments.
The diagnostic value of ratio biomarkers for periprosthetic joint infection
Authors: Wang Xinjie , Zheng Zhongren , Wang Jialiang , Ma Hui , Wang Guodong , Zhao Xiaowei 
Published: April 2023

Abstract
Background
The diagnosis of periprosthetic joint infection (PJI) remains challenging. Currently, there is no single test marker for PJI that has an acceptable level of sensitivity. To enhance diagnostic accuracy, ratio or combined tests have been introduced. Blood testing is crucial as the first step in clinical testing, so this article aims to improve diagnostic efficiency by combining blood test markers.
Methods༚
We conducted a retrospective data collection of 288 patients who underwent total hip or knee joint revision surgery in our hospital from January 2013 to January 2023. A total of 227 patients who met the inclusion criteria were divided into two groups: PJI group (89 cases) and aseptic loosening group (138 cases). Blood test indicators were collected preoperatively as diagnostic indicators for PJI. New diagnostic parameters were formed by combining the indicators through ratios. The diagnostic value of all biomarkers was evaluated using receiver operating characteristic (ROC) curves and area under the curve (AUC), and the optimal cutoff value, positive predictive value (PPV), and negative predictive value (NPV) were further calculated using the Youden index.
Results༚
The PJI group showed significantly higher levels of ESR, CRP, PLT, CLR, ELR, PMR, PLR, SII, and CRP/ALB compared to the aseptic loosening group. The diagnostic performance of serum ratio biomarkers including CRP/WBC, CLR, CRP/FIB, CRP/ALB, CRP/GLB, and CRP/AGR were all above 0.900, with AUCs of 0.902, 0.913, 0.900, 0.908, 0.915, and 0.915, respectively, indicating excellent diagnostic value. CRP/ALB and CRP/AGR had higher diagnostic performance than traditional serum biomarkers ESR (AUC = 0.840) and CRP (AUC = 0.913), with sensitivities of 80.9% and 88.8%, and specificities of 89.9% and 83.3%, respectively.
Conclusion
Compared with traditional markers ESR and CRP, the new ratio combination significantly improved the accuracy and reliability of PJI diagnosis (P < 0.001), among which CRP/ALB and CRP/AGR have good discriminative ability.
The effect of Stress of COVID-19 Pandemic on Sexual Quality Of Life Female and Couples' Relationship Running title: Covid-19 and Sexual quality of life and Couples' Relationship
Authors: Abedi Parvin , Rahmanian Vahid , Ranjbar Afsaneh , jamali safieh , ahmadi zahra 
Published: April 2023

Abstract
Background
This study was conducted to determine the The effect of Stress of COVID-19 Pandemic on Sexual Quality Of Life Female and Couples' Relationship in women
Methods
The participant of this cross sectional study consisted of 395 women who employed online questionnaires using Google Form as the platform in the Iran between November 2022 and December 2022. the data gathering tool was The sexual quality of life-female (SQOL-F), Depression Anxiety Stress Scale(DASS), Relationship Rating Scale (RAS), fear of COVID-19 Scale. Data analysis was performed using descriptive statistics, In the analytical statistics section, independent t-test, one-way ANOVA, Tukey post hoc test and Univariate and Multiple linear regression were used.
Results
The mean score of the sexual quality of life in the participating women was 64.82 ± 11.93, 18.28 ± 4.48 from DASS, 22.48 ± 4.30 from RAS,and 12.88 ± 3.93 from fear of COVID-19 scale. The effect of fear of COVID-19, DASS, and age on sexual quality of life in women was significant and inverse (P < 0.05). This means that with an increase in the score of fear of COVID-19, DASS, and age the mean score of sexual quality of life decreases by 0.419, 0.136, and 0.582 respectively.
Conclusions
the anxiety and stress caused by covid-19 can reduce relationships and sexual performance and reduce the quality of sex. In this regard, studies are suggested a description of prevalence and psychological, communicative and sexual consequences in the country be taken so that vulnerable families can be identified with proper planning and the necessary psychological interventions can be adopted.
The global estimate of premature cardiovascular mortality: a systematic review and meta-analysis of age-standardized mortality rate
Authors: Hasani Wan Shakira Rodzlan , Muhamad Nor Asiah , Hanis Tengku Muhammad , Maamor Nur Hasnah , Wee Chen Xin , Omar Mohd Azahadi , Cheng Kueh Yee , Karim Zulkarnain Abdul , Hassan Muhammad Radzi Abu , Musa Kamarul Imran 
Published: April 2023

AbstractBackground Cardiovascular disease (CVD) is a significant cause of premature mortality worldwide, with a growing burden in recent years. Despite this, there is a lack of comprehensive meta-analyses that quantify the extent of premature CVD mortality. Study addressed this gap by estimating the pooled age-standardized mortality rate (ASMR) of premature CVD mortality. Methods We conducted a systematic review of published CVD mortality studies that reported ASMR as an indicator for premature mortality measurement. All English articles published as of October 2022 were searched in four electronic databases: PubMed, Scopus, Web of Science (WoS), and the Cochrane Central Register of Controlled Trials (CENTRAL). We computed pooled estimates of ASMR using random-effects meta-analysis. We assessed heterogeneity from the selected studies using the I2statistic and performed subgroup analyses by sex, main CVD types, income country level, and study time. The analysis was performed using R software with the “meta” and “metafor” packages. Results A total of 15 studies met the inclusion criteria. The estimated global ASMR for premature CVD mortality was 27.0 per 100,000 people (95% CI: 20.13, 36.21), with heterogeneity among studies (I2 = 99%). Subgroup analysis showed that ASMRs varied by CVD type, with the highest rate for total CVD (ASMR = 96.04, 95% CI: 67.18, 137.31), followed by ischemic heart disease (ASMR = 15.57, 95% CI: 11.27, 21.5) and stroke (ASMR = 12.36, 95% CI: 8.09, 18.91). There were also sex-specific differences, with higher ASMRs for males (37.50, 95% CI: 23.69, 59.37) than females (15.75, 95% CI: 9.61, 25.81). Middle-income countries had a significantly higher ASMR (90.58, 95% CI: 56.40, 145.48) compared to high-income countries (21.42, 95% CI: 15.63, 29.37). Stratifying by study time suggests a reducing trend in ASMR for premature CVD mortality from 2000–2019. Conclusions This meta-analysis synthesized a comprehensive estimate of the worldwide burden of premature CVD mortality. Our findings underscore the continued burden of premature CVD mortality, particularly in middle-income countries. Addressing this issue requires targeted interventions to mitigate the high risk of premature CVD mortality in these vulnerable populations.