bluuebunny/crossref_metadata_2025_split huggingface dataset:
The developmental trajectory of sleep in children with Smith-Magenis syndrome compared to typically developing peers: a 3-year follow-up study
Authors: Agar Georgie , Oliver Chris , Spiller Jayne , Richards Caroline 
Published: September 2023

AbstractStudy ObjectivesTo determine the trajectory of: (i) objective sleep parameters and (ii) caregiver-reported sleep questionnaire scores over 3 years in children with Smith-Magenis syndrome (SMS) compared to age-matched typically developing (TD) controls. We also aimed to (iii) describe individual profiles of change in sleep parameters over time.MethodsWeek-long, overnight actigraphy and questionnaire data from 13 children with SMS and 13 age-matched TD children were collected at Time 1 and Time 2 (3 years later). Independent samples t-tests, paired samples t-tests, and Bayesian analyses were used to compare sleep parameters and sleep questionnaire scores between groups at each time point and compare data within groups to assess change over time.ResultsSleep parameters were consistently more disrupted in the SMS group than the TD group, with significantly reduced sleep efficiency, increased wake after sleep onset and earlier get up times at both time points. This was mirrored in the questionnaire data, with children with SMS evidencing higher scores for overall sleep disturbance, night waking, and daytime sleepiness. While TD sleep parameters demonstrated expected developmental changes over 3 years, in the SMS group sleep parameters and variability between and within children remained largely stable. However, some children with SMS showed substantial variation in sleep parameters over time. Questionnaire scores remained stable over 3 years in both groups.ConclusionsOverall, sleep disturbance appears to be a stable feature of SMS, indicative of a divergent sleep trajectory compared to TD peers. Proactive intervention approaches should be considered for poor sleep in SMS.
Adaptations to a statewide walking program: Use of iterative feedback cycles between research and delivery systems improves fit for over 10 years
Authors: Frazier Mary C , Balis Laura E , Armbruster Shannon D , Estabrooks Paul A , Harden Samantha M 
Published: September 2023

Abstract
FitEx is an 8-week, group-based physical activity and fruit and vegetable consumption program co-created and implemented with the Cooperative Extension System. Effectiveness and delivery personnel perceptions of the program are promising; however, ongoing adaptations are required to continuously meet shifting needs of both researchers and delivery systems. We applied the APDER iterative cycles of implementation over 15 years to understand dynamic and ongoing adaptations as well as implications for FitEx sustainability. Each year, an IRPP between delivery (FitEx deliverers) and research (FitEx developers) systems shared feedback on program core elements and strategies for adaptation through regular team meetings, emails, and evaluations. While the core elements (delivering to groups, goal setting, feedback, and self-monitoring) of FitEx remained consistent, changes were made to address logistical factors, emergent research questions, and technological advancements. For example, program deliverers suggested decreasing training time and making program content available on demand rather than through traditional in-person training. Using APDER with a long-standing IRPP allowed the delivery system to provide feedback to program developers to co-create ongoing adaptations and data-driven decisions. Future work in response to shifting needs includes Fitbit integration and technological updates to the usability of the FitEx platform. Our aim is to report the 15+ years of applying the Assess, Plan, Do, Evaluate, Report (APDER) process with an integrated research–practice partnership (IRPP) for co-creation of ongoing adaptations of FitEx and to share methods for capturing relevant data for decision-making to integrate health promotion programs in community settings.
Cost-per-Response Analysis of Pure Hypochlorous Acid Among Patients with Chronic Venous Leg Ulcers: A Health Economic Analysis
Authors: Niezgoda Jeffrey A. , Niezgoda Jonathan A. , Niezgoda Kathleen M. , Mallow Peter J. 
Published: September 2023

ABSTRACT

OBJECTIVE
To estimate the total cost-per-wound healing response (CPR) and the per-day CPR of patients with chronic leg ulcers treated with pure hypochlorous acid (pHA) as part of their overall would healing regimen.

METHODS
The authors developed a deterministic decision-tree model to estimate the incremental CPR for pHA. The analysis was performed using clinical data from a published single-arm prospective study. The outcome of interest was re-epithelialization at 90 days. Economic data for pHA were based on public prices of pHA per dressing change from the wound care center perspective. The following time points were assessed: 90, 60, and 30 days. Dressing changes occurred every 2.5 days. Sensitivity analysis was performed to gauge the robustness of the results.

RESULTS
A total of 31 patients (68% women) with 31 lesions (average age of wound, 29 months; range, 1-240 months) were included in the clinical study. Re-epithelialization occurred in 23 lesions (74%) at 90 days, 17 (55%) at 60 days, and 3 (10%) at 30 days. The total CPRs were $75.69, $68.27, and $193.44, and the per-day CPRs were $0.84, $1.13, and $6.45 at 90, 60, and 30 days, respectively. The sensitivity analysis revealed that CPRs ranged from $0.63 to $1.12 per day at 90 days.

CONCLUSIONS
Incorporating pHA into standard wound healing protocols is a minimal added expense and may yield a substantial economic savings of $2,695 at 90 days.
Epidemiology trends and progress in breast cancer survival: earlier diagnosis, new therapeutics
Authors: Amato Ottavia , Guarneri Valentina , Girardi Fabio 
Published: September 2023

Purpose of reviewIn this review we will critically appraise the latest evidence on breast cancer (BC) survival trends and discuss how these may reflect breakthroughs in early diagnosis and treatment approaches. We will address the wide global inequalities in BC survival and review the ongoing initiatives aimed at improving cancer control worldwide.Recent findingsBC outcomes have improved in high-income countries during the last decades, following the implementation of strategies for early detection and optimal multimodality treatment. Novel therapeutics, such as anti-HER2 targeted treatments, have also contributed to the progress in BC survival. However, BC mortality is still high in low-income countries, due to the lack of optimal healthcare infrastructures. In the context of marked inequities in BC management across world regions, international collaborations such as the Global Breast Cancer Initiative and the Global Initiative for Cancer Registry Development work to foster capacity-building in developing countries, tackle the burden of BC and deliver the Sustainable Development Goals by 2030.SummaryCollection of robust, high-quality data from population-based cancer registries is crucial to drive and refine public health interventions. Population-based data are also the litmus paper to evaluate the real-world impact of clinical advances and monitor progress.
Recurrence Risk Stratification for Women With FIGO Stage I Uterine Endometrioid Carcinoma Who Underwent Surgical Lymph Node Evaluation
Authors: Ghanem Ahmed I. , Bhatnagar Aseem , Elshaikh Muneer , Hijaz Miriana , Elshaikh Mohamed A. 
Published: September 2023

Objective:
The aim of this study was to estimate the recurrence risk based on the number of prognostic factors for patients with stage I uterine endometrioid carcinoma (EC) who underwent surgical lymph node evaluation (SLNE) and were managed with observation.

Methods:
We queried our database for women with FIGO-2009 stage I EC who underwent surgical staging including SLNE. Multivariate analysis with stepwise model selection was used to determine independent risk factors for 5-year recurrence-free survival (RFS). Study groups based on risk factors were compared for RFS, disease-specific survival, and overall survival.

Results:
A total of 706 patients were identified: median age was 60 years (range, 30 to 93 y) and median follow-up was 120 months. Median number of examined lymph nodes was 8 (range, 1 to 66). 91% were stage IA, 75% had grade 1 and lymphovascular space invasion was detected in 6%. Independent predictors of 5-year RFS included age 60 years and above (P=0.038), grade 2 (P=0.003), and grade 3 (P<0.001) versus grade 1. Five-year RFS for group 0 (age less than 60 y and grade 1) was 98% versus 92% for group 1 (either: age 60 y and older or grade 2/3) versus 84% for group 2 (both: age 60 y and above and grade 2/3), respectively (P<0.001). Five-year disease-specific survival was 100% versus 98% versus 95%, (P=0.012) and 5-year overall survival was 98% versus 90% versus 81%, for groups 0, 1, and 2, respectively (P<0.001).

Conclusions:
In patients with stage I EC who received SLNE and no adjuvant therapy, only age 60 years and above and high tumor grade were independent predictors of recurrence and can be used to quantify individualized recurrence risk, whereas lymphovascular space invasion was not an independent prognostic factor in this cohort.
TESTOSTERONE-INDUCED CENTRAL SEROUS CHORIORETINOPATHY MIMICKING A CHOROIDAL MASS
Authors: Kornblau Ilyse S. , Pritchett David Y. , Wilson Matthew W. 
Published: September 2023

Purpose:
The purpose of this study was to describe a case of supplemental testosterone-induced central serous chorioretinopathy (CSCR) mimicking a choroidal mass in a 63-year-old man.

Methods:
This is a case report on a 63-year-old male patient on self-prescribed supplemental testosterone with CSCR mimicking a choroidal mass.

Results:
A 63-year-old man presented with new-onset vision loss, subretinal fluid, and choroidal mass in his left eye. IV fluorescein angiography showed an enhancing choroidal mass involving the fovea. B-scan ultrasonography revealed diffuse choroidal thickening. Given concern for a diffuse uveal melanoma, the lesion was biopsied showing nondiagnostic rare, atypical melanocytes. Four months after initial presentation, the patient was diagnosed with polycythemia vera. Fourteen months after diagnosis, he admitted to testosterone supplementation. On cessation of the testosterone supplement, the lesion progressively flattened to a chorioretinal scar with subretinal fluid resolution and returned to normal choroidal thickness over the next 14 months.

Conclusion:
Testosterone supplementation has been linked to erythrocytosis and polycythemia vera. In the retina, testosterone supplementation has been linked to CSCR and both central and branch retinal artery and vein occlusions. This case report demonstrates the importance of inquiring about all prescribed and over-the-counter medications in patients presenting with retinal lesions of unknown origin.
Efficacy and Safety of Hyperbaric Oxygen Therapy in Fistulizing Crohn’s Disease
Authors: Dokmak Amr , Sweigart Benjamin , Orekondy Nayantara S. , Jangi Sushrut , Weinstock Joel V. , Hamdeh Shadi , Kochar Gursimran S. , Shen Bo , Levy Alexander N. 
Published: September 2023

Background:
Hyperbaric oxygen therapy (HBOT) delivers 100% oxygen in a pressurized chamber, increasing tissue oxygen levels and regulating inflammatory pathways. Mounting evidence suggests that HBOT may be effective for inflammatory bowel disease. Our systematic review and meta-analysis aimed to quantify the efficacy and safety of HBOT in fistulizing Crohn’s disease (CD).

Methods:
A systematic review was conducted using the EMBASE, Web of Science, Pubmed, and Cochrane Library databases according to the “Preferred Reporting Items for Systematic Reviews and Meta-analyses” criteria. Study bias was assessed using the Cochrane Handbook guidelines.

Results:
Sixteen studies with 164 patients were included in the analysis. For all fistula subtypes, the pooled overall clinical response was 87% (95% CI: 0.70-0.95, I
2 = 0) and the pooled clinical remission was 59% (95% CI: 0.35-0.80, I
2 = 0). The overall clinical response was 89%, 84%, and 29% for perianal, enterocutaneous, and rectovaginal fistulas, respectively. On meta-regression, hours in the chamber and the number of HBOT sessions were not found to correlate with clinical response. The pooled number of adverse events was low at 51.7 per 10,000 HBOT sessions for all fistula types (95% CI: 16.8-159.3, I
2 = 0). The risk of bias was observed across all studies.

Conclusion:
HBOT is a safe and potentially effective treatment option for fistulizing CD. Randomized control trials are needed to substantiate the benefit of HBOT in fistulizing CD.
Prognostic value of cell division cycle-associated protein-3 in prostate cancer
Authors: Gu Peng , Zhang Minhao , Chen Xinhua , Du Jie , Chen Lu , He Xiaoliang , Li Meilin 
Published: September 2023

Background:
The study was aimed to explore cell division cycle-associated protein-3 (CDCA3) expression and its correlation with clinicopathological characteristics, and identification of co-expressed genes of CDCA3 in prostate cancer (PCa).

Methods:
Data for CDCA3 mRNA expression in PCa were obtained from The Cancer Genome Atlas database. Furtherly, CDCA3 protein expression was examined by immunohistochemistry in 80 cases, including 20 normal prostate samples and 60 PCa samples. Then we used “survival” package to obtain the differentially expressed CDCA3 mRNA associated with prognosis of PCa patients. “pROC” package was used to analyze receiver operating characteristic of CDCA3. We used chi-square test, Kruskal–Wallis test and Wilcoxon rank sum test to identify clinicopathological parameters that correlated with CDCA3 expression. In order to determine the effects of CDCA3 expression and clinicopathological parameters on survival, univariate cox regression analysis was performed. Finally, the co-expressed genes of CDCA3 in PCa were explored by search tool for the retrieval of interacting genes, Kyoto encyclopedia of genes and genomes enrichment analysis and Spearman correlation analysis.

Results:
In this study, we found that CDCA3 expression was increased in PCa. PCa patients with higher CDCA3 expression had poor outcomes. In terms of receiver operating characteristic, CDCA3 had an area under the curve of 0.857. High CDCA3 expression was positively correlated with advanced T stage, N stage, Gleason score, and served as an independent predictor of progress free interval in PCa patients. Then 20 proteins closely related to CDCA3 were screened through STRING website. Functional enrichment analysis revealed that, Kyoto encyclopedia of genes and genomes pathway was mainly enriched in cell cycle, including 6 genes, BUB1, CCNA2, CDK1, CDC20, TTK, and CCNB2.

Conclusion:
CDCA3 is significantly associated with the prognosis of PCa, which may be an indicator of the diagnosis and prognosis of PCa and a new therapeutic target.
Methylprednisolone or dexamethasone? How should we choose to respond to COVID-19?: A systematic review and meta-analysis of randomized controlled trials
Authors: Li Zhengning , Xue Yuan , Li Laodong , Li Chaoqian 
Published: September 2023

Background:
Methylprednisolone (MP) and dexamethasone (DXM) are commonly prescribed hormone drugs for treating coronavirus pandemic disease 2019 (COVID-19) patients, but conflicting results from previous studies and meta-analyses on their efficacy and safety necessitate further investigation. Therefore, in this study, we conducted a systematic review and meta-analysis of randomized controlled trials to enhance the level of evidence and compare the efficacy and safety of MP and DXM in COVID-19 patients.

Methods:
We conducted a comprehensive search of PubMed, Web of Science, Embase, and Cochrane Library databases to retrieve randomized clinical trials. Our primary outcome measure was all-cause mortality, with secondary outcomes including admission to the intensive care unit, length of hospital stay, mechanical ventilation, and adverse events.

Results:
This study analyzed six randomized controlled trials involving 1403 patients (MP group: 704; DXM group: 699). The results of the analysis showed no significant differences in mortality rates, admission to intensive care units, hospitalization time, mechanical ventilation, or adverse events between the MP and DXM groups (P > .05). However, a significant difference was observed in the incidence of hyperglycemia between these 2 groups (RR = 1.78, 95% CI [1.09, 2.89], P = .02, I
2 = 78%).

Conclusion:
The results of this meta-analysis showed that there was no difference in mortality, ICU admission rate, hospital stay, mechanical ventilation, or adverse events between MP and DXM in the treatment of COVID-19. The incidence of hyperglycemia with methylprednisolone was higher than that with dexamethasone.
The role of acupuncture in women with advanced reproductive age undergoing in vitro fertilization-embryo transfer: A randomized controlled trial and follicular fluid metabolomics study
Authors: Xia Qingchang , Yu Lingyu , Song Jingyan , Sun Zhengao 
Published: September 2023

Background:
The objective of this study was to determine the efficacy of acupuncture on the outcome of in vitro fertilization (IVF) in elderly infertile patients with kidney qi deficiency, and to explore its possible mechanism from the perspective of pseudo-targeted metabolomics of follicular fluid.

Methods:
Sixty cases of elderly women undergoing IVF were sampled and randomly divided into 2 equal groups: the treatment and the elderly control (HA) group. In the treatment group, routine ovulation induction combined with acupuncture treatment was used. Routine ovulation induction combined with sham acupuncture was used in the HA group. Reproductive outcomes of the 2 groups were compared. The follicular fluid of patients obtained on the day of oocyte retrieval was analyzed by the ultra-high-performance liquid chromatography-mass spectrometry analysis system.

Results:
Compared with the HA group, the score of kidney qi deficiency syndrome in the treatment group was significantly decreased, and the 2 PN fertilization rate, high-quality embryo rate and cumulative pregnancy rate were significantly increased (P < .05). Through the identification of target metabolites, 3 metabolic pathways were found to be closely related to the developmental potential of oocytes, namely: Retinol metabolism pathway; Glycine, serine, and threonine metabolism pathway; Glycerophospholipid metabolism pathway.

Conclusion:
From our findings, acupuncture can improve the quality of oocytes thus bettering the outcome of IVF-assisted pregnancy in elderly patients with kidney qi deficiency.

Trial registration:
ChiCTR1800018329.
Intraocular pressure measurement using ICare rebound tonometer in different positions of eye and different locations on cornea
Authors: Wongwanwatana Sirada , Treesit Isaraporn , Funarunart Panrapee , Iemsomboon Wallop , Choontanom Raveewan 
Published: September 2023

Intraocular pressure (IOP) is one of the most crucial aspects for diagnosis and treatment plan among patients with glaucoma. Although the gold standard for IOP measurement is Goldmann applanation tonometer (GAT)[1], it must be mounted to a slit lamp biomicroscope. However, rebound tonometer has become popular due to its ease of operation and portable design, does not require topical anesthesia, and results do not differ significantly from those of GAT[2].
The purpose of this cross-sectional study is to investigate the difference in IOP measurement with iCare IC200 in different angles of the eye and different corneal locations. All participants underwent IOP measurement by GAT twice. Then, IOP was measured with iCare by a single physician. IOP was measured in a straight manner in the upright patient position; then participants were asked to look at fixation targets, which located in four different points. IOP was measured in upgaze, downgaze, medial gaze, and lateral gaze. Then, IOP was measured at 2 mm from limbus in superior, inferior, nasal, and temporal cornea. All methods were measured twice, and the mean was used for calculation. The physician who measured IOP by iCare was masked from GAT results. A total of 168 eyes were tested with a mean age of 62.15 ± 12.34 years. Mean IOP measured by GAT and iCare at the central cornea was 15.53 ± 5.57 and 14.78 ± 6.14 mmHg, respectively. The standardized mean difference (SMD) between iCare and GAT was 0.13 (-0.09-0.34), which is insignificant. The average IOP was 0.6, 0.47, 0.91, and 0.44 mmHg lower than the primary position in upgaze, downgaze, medial gaze, and lateral gaze 15 degrees angulated positions respectively (p<.01). IOPs at 2 mm from limbus in the inferior, nasal, and temporal cornea were 0.5, 0.69, and 0.57 mmHg lower than IOP measured at the central cornea (p=<.01). IOP measurements with iCare in different angles of eye were statistically significantly lower than in the primary position. Similarly, IOPs at different locations on cornea were lower than at the central cornea. However, the difference in IOP measurements with iCare in different angles of the eye and different corneal locations was in the trivial range and might be clinically insignificant.
Survival and prognosis analysis of systemic lupus erythematosus patients with pulmonary hypertension: A systematic review and meta-analysis
Authors: Yang Jianguo , Zhou Fuyu , Zhou Xinpeng , Sun Yuying , Lun Xueping , Cao Jiaojiao , Fan Bing 
Published: September 2023

Background:
The study aimed to evaluate survival rates and prognosis in systemic lupus erythematosus (SLE) patients with pulmonary hypertension (PH) using meta-analysis.

Methods:
PubMed, EMBASE, Cochrane central register of controlled trials, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wan-Fang Database, and Chinese biomedical database were searched. Information and data were screened and extracted by 2 researchers. The obtained data were analyzed using the R software meta package. Quality assessment was conducted using Newcastle-Ottawa Scale. The causes of heterogeneity were analyzed using subgroup analysis and sensitivity analysis. Publication bias was evaluated using Begger funnel plots and Egger test.

Results:
The search strategy yielded a total of 21 studies involving 875 patients included in the final analysis. The pooled 1-, 3- and 5-year survival rates of patients with SLE-PH were 0.9020 (95%CI: 0.8576; 0.9397), 0.8363 (96%CI: 0.7813; 0.8852), 0.7301 (95%CI: 0.6327; 0.8181). The 1-, 3- and 5-year survival rates of echocardiography subgroup were 0.9000 (95%CI: 0.8480; 0.9551), 0.8435 (95%CI: 0.7744; 0.9187), 0.6795 (95%CI: 0.5746; 0.8035), respectively; and there were 0.9174 (95%CI: 0.8951; 0.9402), 0.8529 (95%CI: 0.8255; 0.8812), 0.7757 (95%CI: 0.7409; 0.8121) at right heart catheterization subgroup in the meantime. Multivariate analysis for predicting mortality in SLE-PH patients revealed that diminishing left ventricular ejection fraction, New York Heart Association classification, lupus nephritis, lower cardiac index, and higher red blood cell distribution width level were significantly associated with a higher mortality rate. Treatment with huge doses of cyclophosphamide, tricuspid annular plane systolic excursion/pulmonary artery systolic pressure, and Raynaud phenomenon signaled favorable outcomes.

Conclusion:
The 1-, 3-, and 5-year survival rates of SLE-PH patients in recent years (0.9020, 0.8363, 0.7301) were estimated in this study. SLE-PH patients diagnosed by echocardiography have a worse long-term prognosis than those diagnosed by right heart catheterization. Studies after 2015 have shown significantly better survival than earlier studies.