bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Risiko Saham Dengan COVID-19
Authors: Anggara I Gde Wahyu Purna 
Published: April 2023

COVID-19 has affected all aspects of life, including capital markets around the world, including Indonesia. This study aims to look at the impact of COVID-19 on changes in risk in stocks. Stock risks that are the object of research are overall risk (variance return) and market-based risk (stock beta). The research method used is a quantitative approach with a population of all company shares listed on the Indonesia Stock Exchange (IDX) with purposive sampling, where a sample of 67 companies was obtained. There is a significant difference between the total stock risk before the COVID-19 pandemic and during the COVID-19 pandemic. There is an increase in total stock risk during the COVID-19 pandemic. Furthermore, there is a significant difference between market risk before the COVID-19 pandemic and during the COVID-19 pandemic.
Keywords: Stock; COVID-19; Return; Stock Risk
Treatment of Oil Well Drill Cuttings Utilizing Different Binder Options
Authors: Abdullah Raad M. , Othman Mohammed A. , Abdullah Siraj M. 
Published: April 2023

A lab-scale treatability experiment was conducted on oil well drill cuttings (waste generated during petroleum exploration) using two different binders (Portland Cement and Lime) as a Solidification and Stabilization S/S agent. Seven ratios for each binder to waste (Drill cuttings) have been separately prepared (0.25:10, 0.5:10, 1:10, 2:10, 3:10, 4:10, 5:10) in which effects for each ratio and curing time (90 days) have been investigated on pH, chloride, and leachate for heavy metals (Ba, Pb, Cd, Ag, and Cr) through Toxicity Characteristic Leaching Procedure (TCLP). Results presented that the leaching of heavy metals (Ba, Cd, Cr, and Ag) was under the US EPA TCLP limit for all ratios with both binders. However, the Pb for the ratios of 0.25:10, 0.5:10, 2:10, and 3:10 for the cement-treated drill cuttings and 0.25:10 and 0.5:10 for the lime-treated drill cuttings have exceeded the proposed limit by the US EPA TCLP limit. Chloride also failed to meet the Nigerian chloride limit for drill cutting with the ratios 0.25:10, 0.5:10, 1:10, and 2:10 for both binders; meanwhile, the chloride concentrations were under the same limit within the ratios 3:10, 4:10, and 5:10. The overall results indicated that the binder options had affected the S/S product. Furthermore, the ratios of 1:10 and 2:10 had better performance considering the weight of the binders used for both options. The ratios of 4:10 and 5:10 had also performed well, but due to the significant quantities of the binders used, these ratios will not be considered economically feasible. The present investigation demonstrated that both binders could be used and relied on as an S/S agent aiming at treating drill cuttings.

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Efficacy of Photodynamic Therapy with Chlorine-Based Photosensitizer in the Treatment of Basal Cell Carcinomas
Authors: Artsemyeva T.P. , Tzerkovsky D.A. 
Published: April 2023

The aim of this study is to evaluate a safety and antitumor efficacy of photodynamic therapy (PDT) with chlorine-based photosensitizer (PS) for treatment patients with basal cell skin carcinomas (BCC).
Material and Methods: The work was performed on the basis of the Department of hyperthermia and photodynamic therapy. The object of the study were 172 patients with a verified diagnosis of BCC (T1N0M0, I stage), who received treatment from 2007 to 2022. PS «Photolon» (RUE «Belmedpreparaty», Republic of Belarus) was administrated intravenously at a dose of 2.0-2.5 mg/kg. The session of PDT was performed 2.5-3 h after intravenous injection of PS using semiconductor lasers (λ=660±5 nm) with exposure doses 50-250 J/cm² and power density – 0.15-0.5 W/cm². Frequency and severity of side effects after treatment session was assessed based on the criteria CTCAE (Version 4.03; 2010). The antitumor efficacy was evaluated 3 months after treatment. Clinical outcome was evaluated visually and morphologically by cytological or histopathological examination. Performance criteria were as follows (according to WHO, 1979).
Results: The phenomenon of skin phototoxicity due to violation of the light regime (hyperemia, burning, slight swelling of the soft tissues of the face; CTCAE, I-II grades) was registered in 5.8% of cases (n=10). Serious adverse reactions (anaphylactic shock, Quincke's edema, severe pain syndrome) after the administration of PS and photoirradiation were not identified. Complete and partial regressions of tumors was observed in 93.0% and 4.7% of patients, respectively. The objective answer was 97.7%. The frequency of local relapses of the disease 1, 2, 3, 4 and 5 years after PDT was 3.1%, 3.1%, 4.6%, 4.6% and 6.9%, respectively.
Сonclusion: PDT is a well-tolerated and highly effective therapeutic option in patients with BCC.
Precognition at the Boundaries
Authors: Mossbridge Julia 
Published: April 2023

The rigorous scientific study of precognition, the human ability to accurately predict future events that are not already predictable based on information about the past or from the five senses, spans the last 90 years. This review describes different types of precognition, underscores the basic principles of precognition research, and discusses the evidence for and potential mechanisms of two very different forms of precognition: 1) mostly unconscious precognition with short lead times (e.g., presentiment) and 2) mostly conscious precognition with longer lead times (e.g., precognitive remote viewing). I describe two potential models to explain each of these forms of precognition, along with ideas for empirical tests of each one.
Evaluation de l'application regionale du programme de retrait preventif de la travailleuse enceinte
Authors: Allie Robert 
Published: April 2023

Abstract: We have evaluated two aspects of the application of the preventive withdrawal program for pregnant workers or those who breastfeed (PWPWB) in the Ste-Croix Community Health Department area. These two aspects are the diffusion of the program in the area and the effectiveness of our processing mechanism for PWPWB inquiries. About the diffusion, we have been able to estimate a penetration rate reaching 40%. Furthermore, the diffusion by zone and by economic sector have also been analysed. As for the inquiry processing, it has been possible to bring to light a different attitude from some physicians. An analysis of inquiry processing delay revealed that it was less than a week.
Frontotemporal giant extradural dermoid cyst: illustrative case
Authors: Cao Dan , Xu Houyun , Hu Jibo , Mo Jun , Yu Xiping , Wang Junli , Hu Hongjie 
Published: April 2023

BACKGROUND
Dermoid cyst is a rare benign tumor exhibiting a typical radiological pattern and most commonly located along the midline. Laboratory examination was always normal. However, the features of some rare cases are atypical that can be easily misdiagnosed as other tumors.

OBSERVATIONS
A 58-year-old patient presented with tinnitus, dizziness, blurred vision, and gait unsteadiness. Laboratory examination showed the serum levels of carbohydrate antigen 19-9 (CA19-9) were significantly increased (186 U/mL). A computed tomography (CT) scan revealed a predominant hypodense lesion in the left frontotemporal region with a hyperdense mural nodule. The lesion appeared as an intracranial extradural mass with a mural nodule on the sagittal image, displaying mixed signal on T1- and T2-weighted imaging. A left frontotemporal craniotomy was performed for cyst resection. Histological results confirmed a diagnosis of dermoid cyst. No tumor recurrences were observed at the 9-month follow-up.

LESSONS
Extradural dermoid cyst with a mural nodule is extremely rare. When a hypodense lesion on CT shows mixed signal on T1- and T2-weighted imaging with a mural nodule, even if it is located in the extradural areas, it is important to consider a dermoid cyst. Serum CA19-9 combined with atypical imaging features may contribute to the diagnosis of dermoid cysts. Only recognition of atypical radiological features can avoid misdiagnosis.
Ventral intermediate nucleus deep brain stimulation for treatment-resistant focal aware motor seizures: illustrative case
Authors: Vilela-Filho Osvaldo , _ _ , Ragazzo Paulo C. , Goulart Lissa C. , Arruda Francisco , Arruda Mariana L. , Milhomem Caroline B. S. S. , Silva-Filho Hélio F. 
Published: April 2023

BACKGROUND
Resection of the seizure onset zone (SOZ) is considered the gold standard for treating refractory focal aware seizures (FASs). When resective surgery is unadvisable, deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT; ANT-DBS) has been the procedure of choice. However, less than half of patients with FASs respond to ANT-DBS. The need for alternative targets to effectively treat FAS is thus evident.

OBSERVATIONS
The authors report the case of a 39-year-old woman presenting with pharmaco-resistant focal aware motor seizures, with the SOZ located in the primary motor cortical area. She had previously undergone unsuccessful resection of the left temporoparietal operculum elsewhere. Considering the risk of new resective surgery, she was offered combined ventral intermediate nucleus (Vim)/ANT-DBS. Vim-DBS proved to be superior to ANT-DBS for seizure control (88% vs 32%), although the association of both provided the best results (97%).

LESSONS
This is the first report on the use of the Vim as a target of DBS for the treatment of FAS. The excellent results were presumably obtained by modulation of the SOZ through Vim projections to the motor cortex. This opens a completely new avenue for treating FAS: chronic stimulation of specific thalamic nuclei.
ЛІКВІДНІСТЬ, ДІЛОВА АКТИВНІСТЬ І РЕНТАБЕЛЬНІСТЬ: ХАРАКТЕРИСТИКА ТА ОСОБЛИВОСТІ ВИЗНАЧЕННЯ ОКРЕМИХ ПОКАЗНИКІВ
Authors: Pavelko O. V. , Popchuk D. O. 
Published: April 2023

У статті досліджено економічну сутність фінансового стану підприємства. Розглянуто тлумачення даного поняття різними науковцями. Сформовано власну ідентифікацію сутності окресленої економічної категорії. Висвітлено економічний зміст показників ліквідності, ділової активності та рентабельності. Встановлено необхідність проведення оцінки фінансового стану в системі фінансового управління підприємством. Проаналізовано динаміку означених показників для господарюючого суб’єкта – ПП «ДеЛісс» за 2020–2021 рр. Запропоновано шляхи удосконалення фінансового стану досліджуваного суб’єкта.
Using the AR-V7 biomarker to determine treatment in metastatic castrate resistant prostate cancer, a feasibility randomised control trial, conclusions from the VARIANT trial
Authors: Gravestock Paul , Clark Emma , Morton Miranda , Sharma Shirya , Fisher Holly , Walker Jenn , Wood Ruth , Hancock Helen , Waugh Nichola , Cooper Aislinn , Maier Rebecca , Marshall John , Chandler Robert , Bahl Amit , Crabb Simon , Jain Suneil , Pedley Ian , Jones Rob , Staffurth John , Heer Rakesh 
Published: April 2023

Background: Prostate cancer is the most commonly diagnosed malignancy in the UK. Castrate resistant prostate cancer (CRPC) can be difficult to manage with response to next generation hormonal treatment variable. AR-V7 is a protein biomarker that can be used to predict response to treatment and potentially better inform management in these patients. Our aim was to establish the feasibility of conducting a definitive randomised controlled trial comparing the clinical utility of AR-V7 biomarker assay in personalising treatments for patients with metastatic CRPC within the United Kingdom (UK) National Health Service (NHS). Due to a number of issues the trial was not completed successfully, we aim to discuss and share lessons learned herein.Methods: We conducted a randomised, open, feasibility trial, which aimed to recruit 70 adult men with metastatic CRPC within three secondary care NHS trusts in the UK to be run over an 18-month period. Participants were randomised to personalised treatment based on AR-V7 status (intervention) or standard care (control). The primary outcome was feasibility, which included: recruitment rate, retention and compliance. Additionally, a baseline prevalence of AR-V7 expression was to be estimated.Results: Fourteen participants were screened and 12 randomised with six into each arm over a nine-month period. Reliability issues with the AR-V7 assay meant prevalence was not estimated. Due to limited recruitment the study did not complete to target.Conclusions: Whilst the trial did not complete to target, we have ascertained that men with advanced cancer are willing to take part in trials utilising biomarker guided treatment. A number of issues were identified that serve as important learning points in future clinical trials.
Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility
Authors: Simila Hazel O. , Boccaccini Aldo R. 
Published: April 2023

Introduction: The sol-gel method for production of mesoporous bioactive glass nanoparticles (MBGNs) has been adapted to synthesize tricalcium silicate (TCS) particles which, when formulated with other additives, form the gold standard for dentine-pulp complex regeneration. Comparison of TCS and MBGNs obtained by sol-gel method is critical considering the results of the first ever clinical trials of sol-gel BAG as pulpotomy materials in children. Moreover, although lithium (Li) based glass ceramics have been long used as dental prostheses materials, doping of Li ion into MBGNs for targeted dental applications is yet to be investigated. The fact that lithium chloride benefits pulp regeneration in vitro also makes this a worthwhile undertaking. Therefore, this study aimed to synthesize TCS and MBGNs doped with Li by sol-gel method, and perform comparative characterizations of the obtained particles.Methods: TCS particles and MBGNs containing 0%, 5%, 10% and 20% Li were synthesized and particle morphology and chemical structure determined. Powder concentrations of 15mg/10 mL were incubated in artificial saliva (AS), Hank’s balanced saline solution (HBSS) and simulated body fluid (SBF), at 37°C for 28 days and pH evolution and apatite formation, monitored. Bactericidal effects against S. aureus and E. coli, as well as possible cytotoxicity against MG63 cells were also evaluated through turbidity measurements.Results: MBGNs were confirmed to be mesoporous spheres ranging in size from 123 nm to 194 nm, while TCS formed irregular nano-structured agglomerates whose size was generally larger and variable. From ICP-OES data, extremely low Li ion incorporation into MBGNs was detected. All particles had an alkalinizing effect on all immersion media, but TCS elevated pH the most. SBF resulted in apatite formation for all particle types as early as 3 days, but TCS appears to be the only particle to form apatite in AS at a similar period. Although all particles had an effect on both bacteria, this was pronounced for undoped MBGNs. Whereas all particles are biocompatible, MBGNs showed better antimicrobial properties while TCS particles were associated with greater bioactivity.Conclusion: Synergizing these effects in dental biomaterials may be a worthwhile undertaking and realistic data on bioactive compounds targeting dental application may be obtained by varying the immersion media.
Androgen serum levels in male patients with adrenocortical carcinoma given mitotane therapy: A single center retrospective longitudinal study
Authors: Delbarba Andrea , Cosentini Deborah , Facondo Paolo , Laganà Marta , Pezzaioli Letizia Chiara , Cremaschi Valentina , Alberti Andrea , Grisanti Salvatore , Cappelli Carlo , Ferlin Alberto , Berruti Alfredo 
Published: April 2023

ObjectiveHypogonadism is common in male patients with adrenocortical carcinoma (ACC) who are under treatment with mitotane, but the phenomenon is underestimated, and its prevalence has been poorly studied. This single-center retrospective longitudinal study was undertaken to assess the frequency of testosterone deficiency before and after mitotane therapy, the possible mechanism involved, and the relationship between hypogonadism with serum mitotane levels and prognosis.Research design and methodsConsecutive male ACC patients followed at the Medical Oncology of Spedali Civili Hospital in Brescia underwent hormonal assessment to detect testosterone deficiency at baseline and during mitotane therapy.ResultsA total of 24 patients entered the study. Of these patients, 10 (41.7%) already had testosterone deficiency at baseline. During follow-up, total testosterone (TT) showed a biphasic evolution over time with an increase in the first 6 months followed by a subsequent progressive decrease until 36 months. Sex hormone binding globulin (SHBG) progressively increased, and calculated free testosterone (cFT) progressively decreased. Based on cFT evaluation, the proportion of hypogonadic patients progressively increased with a cumulative prevalence of 87.5% over the study course. A negative correlation was observed between serum mitotane levels &gt;14 mg/L and TT and cFT.ConclusionTestosterone deficiency is common in men with ACC prior to mitotane treatment. In addition, this therapy exposes these patients to further elevated risk of hypogonadism that should be promptly detected and counteracted, since it might have a negative impact on quality of life.
A novel pyroptosis-related prognostic signature for lung adenocarcinoma: Identification and multi-angle verification
Authors: Wang Xinyue , Zhou Jing , Li Zhaona , Chen Xiuqiong , Wei Qianhui , Chen Kaidi , Jiang Richeng 
Published: April 2023

Background: Lung adenocarcinoma (LUAD) is an aggressive disease of heterogeneous characteristics with poor prognosis and high mortality. Pyroptosis, a newly uncovered type of programmed cell death with an inflammatory nature, has been determined to hold substantial importance in the progression of tumors. Despite this, the knowledge about pyroptosis-related genes (PRGs) in LUAD is limited. This study aimed to develop and validate a prognostic signature for LUAD based on PRGs.Methods: In this research, gene expression information from The Cancer Genome Atlas (TCGA) served as the training cohort and data from Gene Expression Omnibus (GEO) was utilized as the validation cohort. PRGs list was taken from the Molecular Signatures Database (MSigDB) and previous studies. Univariate Cox regression and Lasso analysis were then conducted to identify prognostic PRGs and develop a LUAD prognostic signature. The Kaplan-Meier method, univariate and multivariate Cox regression models were employed to assess the independent prognostic value and forecasting accuracy of the pyroptosis-related prognostic signature. The correlation between prognostic signature and immune infiltrating was analyzed to examine the role in tumor diagnosis and immunotherapy. Further, RNA-seq as well as quantitative real-time polymerase chain reaction (qRT-PCR) analysis in separate data sets was applied in order to validate the potential biomarkers for LUAD.Results: A novel prognostic signature based on 8 PRGs (BAK1, CHMP2A, CYCS, IL1A, CASP9, NLRC4, NLRP1, and NOD1) was established to predict the survival of LUAD. The prognostic signature proved to be an independent prognostic factor of LUAD with satisfactory sensitivity and specificity in the training and validation sets. High-risk scores subgroups in the prognostic signature were significantly associated with advanced tumor stage, poor prognosis, less immune cell infiltration, and immune function deficiency. RNA sequencing and qRT-PCR analysis confirmed that the expression of CHMP2A and NLRC4 could be used as biomarkers for LUAD.Conclusion: We have successfully developed a prognostic signature consisting of eight PRGs that providing a novel perspective on predicting prognosis, assessing infiltration levels of tumor immune cells, and determining the outcomes of immunotherapy for LUAD.
The association of maternal smoking and other sociobehavioral factors with dental caries in toddlers: A cross-sectional study
Authors: Sobiech Piotr , Olczak-Kowalczyk Dorota , Spodzieja Karolina , Gozdowski Dariusz 
Published: April 2023

BackgroundSevere early childhood caries (S-ECC) is a form of dental caries in toddlers, which can strongly affect general health and quality of life. Studies on factors that can contribute to the development of caries immediately after tooth eruption are sparse. The aim of this study was to assess the role of sociobehavioural factors and pre- and postnatal exposure to tobacco smoke in the aetiology of dental caries in children up to 3 years old.MethodsA cross-sectional study was conducted between 2011 and 2017 to assess oral health and teething in urban children 0–4 years of age. The number of teeth and surfaces with white spot lesions (d1,2), as well as decayed (d), missing (m), and filled (f) teeth classified according to ICDAS II was evaluated in a dental office setting. d1,2dmft and d1,2dmfs were calculated. Severe early childhood caries was diagnosed for d1,2dmfs &gt; 0. Parents completed a self-administered questionnaire on socioeconomic factors, maternal health, course of pregnancy, child's perinatal parameters, hygiene and dietary practices, as well as maternal smoking during and after pregnancy. Data on children aged 12–36 months were collected and analysed statistically using the t-test, Spearman rank correlations and Poisson regression. Significance level was set at 0.05.ResultsDental caries was found in 46% of 496 children aged 12–36 months. Mean d1,2dmft and d1,2dmfs were 2.62 ± 3.88 and 4.46 ± 8.42, respectively. Tobacco smoking during and after pregnancy was reported by 8.9% and 24.8% of women, respectively. Spearman's rank correlation analysis confirmed a relationship between S-ECC and parental education, maternal smoking, bottle feeding, avoiding springy foods, number of meals, and the age of tooth brushing initiation. Pre- and postnatal exposure to tobacco smoke increased the risk of S-ECC especially in children in age 19–24 months. Maternal smoking was correlated with the level of education and dietary practices.ConclusionOur study confirmed that prenatal smoking is associated with increased risk of severe-early childhood caries (S-ECC) while the association with post-natal smoking is also evident, the increase in risk is not statistically clear. Both maternal smoking and the child's tooth decay are associated with poor parental education and other improper oral health behaviours. The positive impact of quitting smoking on the oral health in children should be part of anti-smoking advice.