bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infective endocarditis and COVID-19: the impact of SARS-CoV-2 infection on diagnostics, course, and prognosis
Authors: Kotova E. O. , Pisaryuk A. S. , Kobalava Zh. D. , Timofeeva Yu. A. , Chipigina N. S. , Karaulova Yu. N. , Ezhova L. G. 
Published: February 2023

Aim. To study the impact of coronavirus disease 2019 (COVID-19) pandemic on hospitalization rates, diagnosis, and outcomes of infective endocarditis (IE) with a subanalysis of IE course in combination with COVID-19.Material and methods. This prospective cohort study included 168 patients with definite or probable IE (DUKE 2015) hospitalized in the V.V. Vinogradov City Clinical Hospital from July 2017 to July 2022. All patients underwent a conventional examination in accordance with current clinical guidelines. We studied clinical, paraclinical and etiological parameters, as well as outcomes.Two clinical observations of the combination of IE and COVID-19 are presented.Results. When assessing the local registry of patients with IE, a trend towards an increase in hospitalizations rate of IE in 2021-2022 was shown, with a decrease during the period of long-term lockdowns in Moscow and a subsequent surge after their cancellation. Patients with IE during the COVID-19 pandemic had a more favorable clinical profile, a 2-fold increase in IE diagnosis (due to late hospitalization), frequent detection of Staphylococcus aureus MSSA (32,6%), and frequent surgical treatment (up to 87,6% with a combination of IE and COVID-19), as well as high in-hospital mortality, but without a tendency to increase (30,4%). Clinical observations of IE and COVID-19 combination are presented, which demonstrates the contribution of COVID-19 as the only risk factor for native tricuspid valve IE in a patient without predisposing causes, as well as a factor in the unfavorable prognosis for native aortic valve IE after the addition of COVID-19, which led to lethal outcome.Conclusion. The present study demonstrates the profile of patients with IE and COVID-19 depending on the epidemiological situation of COVID-19 and the association with SARS-CoV-2 infection. The data obtained make it possible to discuss the potential relationship between COVID-19 and IE. The "endocarditis team" determines the timely implementation of surgery and the absence of an increase in inhospital mortality, regardless of the epidemiological situation.
Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction
Authors: Kobalava Zh. D. , Safarova A. F. , Lapshin A. A. 
Published: February 2023

Aim. To assess non-invasive parameters of left ventricular (LV) myocardial work in patients with heart failure with reduced ejection fraction (CHrEF) and iron deficiency (ID) after ferric carboxymaltose (FCM) therapy.Material and methods. There were following inclusion criteria: LV ejection fraction (EF) ≤40%; body >70 kg, receiving best medical therapy (BMT) in recommended doses in accordance with the guidelines of the European Society of Cardiology and the Russian Society of Cardiology. Median age was 67±11,7 years (men, 83%), while median LVEF and N-terminal pro-brain natriuretic peptide was 29% and 315 ng/ml, respectively. Patients were randomized by the envelope method. The first group consisted of 19 patients who received therapy with intravenous FCM 1500 mg in 2 injections with an interval of one week between injections in addition to BMT. The control group consisted of 16 patients who received BMT without FCM. All patients underwent a standard echocardiography, and non-invasive LV myocardial work was assessed immediately before inclusion in the study and after 3 months.Results. In the first group of patients receiving FCM therapy, an increase in LVEF (29,1±10,3 vs 35,4±11,1; p=0,001), mitral annular plane systolic excursion (1,2 (1;1,6 ) vs 1,5 (1,3;1,9), p=0,001), LV global longitudinal strain (-7 (-5;-8) vs -8 (-6;-11), p=0,007) and non-invasive indicators of myocardial work (global work index (826±314 vs 1041±354), p=0,0001; global constructive work (1173±388 vs 1435±405), p=0,0001; global work efficiency (85 (82;87) vs 86 (82;88), p=0,017)). There were no significant changes in the studied parameters in the BMT group.Conclusion. Patients with HFrEF and ID treated with FCM showed a significant increase in LV systolic function, including non-invasive myocardial work parameters, compared with the control group.
KARŞILAŞTIRMALI HUKUK AÇISINDAN ALMANYA VE TÜRKİYE'DE VERGİ KAÇAKÇILIĞI UYGULAMALARI
Authors: YENİAY Ali 
Published: February 2023

Toplumların refah düzeyinin yükseltilmesinde önemli bir role sahip olan devletler, görevlerini yerine getirebilmek için gelirlere ihtiyaç duyarlar. Vergiler, devlet için gelir kaynakları oluşturmada önemli bir rol oynamaktadır. Bu nedenle vergi konusu tarih boyunca en önemli tartışma konularından biri olmuş ve günümüzde de önemini sürdürmeye devam etmektedir. Vergiler, ana gelir kaynağı olarak kritik bir öneme sahiptir. Vergi Kaçakçılığı ise toplumların refahını olumsuz yönde etkileyen en önemli sorunlardan biridir. Ayrıca bir maliye politikası aracı olarak, kişisel harcanabilir gelir ve nispi fiyatlar üzerindeki etkileri nedeniyle diğer ekonomik birimler için önemli arz etmektedir. Bu anlamda, toplumsal refahın maksimize edilmesi için etkin ve adil bir vergi sisteminin oluşturulması bir zorunluluktur. Türkiye özellikle 1949'daki uyumdan bu yana Alman Genel Vergi Kanunu'na dayalı vergi prosedürünü uygulamaktadır. Hem Alman hem de Türk vergi usul sistemi, hukuk devleti, eşitlik ve yasal güvenlik ilkeleri üzerine kurulmuştur. Alman Vergi Usul Kanunu’nda “Vergi Kaçakçılığı” suçu yanlış beyan yada gizleme, vergi açıklama görevlerinin ihmali ve vergiden kaçınılması olarak tanımlanmakta ve 5 yıl ve para cezası gibi müeyyideler uygulanmaktadır. Benzer şekilde Vergi Kaçakçılığı 2008 tarihinden sonra Türk Vergi Usul Kanunu açısından basit bir kabahat olmaktan çıkmış ve Türk Ceza Kanunu kapsamında bir suç olarak belirlenmiştir. Bu çalışmada Almanya ve Türkiye'de Vergi Kaçakçılığı Uygulamaları ele alınmış ve Karşılaştırmalı Hukuk açısından incelenmiştir.
The role of mast cells and their proteases in lung damage associated with COVID-19
Authors: Budnevsky A. V. , Avdeev S. N. , Ovsyannikov E. S. , Shishkina V. V. , Esaulenko D. I. , Filin A. A. , Savushkina I. A. , Perveeva Inna M. , Alekseeva N. G. 
Published: February 2023

The new coronavirus infection COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2, has posed scientific and public health challenges. The problem of treating COVID-19 still remains, and the pathogenesis of COVID-19 needs to be studied in detail, including the involvement of mast cells (MCs) and their specific proteases.The aim of this study was to characterize the role of mast cell proteases chymase, tryptase, and carboxypeptidase A3 (CPA3) in the lung damage associated with COVID-19.Methods. The study included postmortem lung biopsies from 30 patients who died of severe COVID-19, and biopsies from 9 control group patients. Histological preparations were made and protease profile and degranulation activity of MCs were analyzed. In addition, some demographic, clinical, and laboratory parameters were analyzed.Results. The average number of tryptase-positive MCs without evidence of degranulation and the total number of CPA3-positive MCs were statistically significantly higher in patients with COVID-19, and the number of tryptase-positive and CPA3-positive MCs fragments was lower compared with controls. Negative correlations were established between the numbers of tryptase-positive MCs and red blood cell count. Negative correlations were found between non-granulating tryptase-positive MCs and hemoglobin levels. Positive correlations were noted between tryptase-positive MCs and the leukocytes and eosinophils counts, and negative correlations were noted between the number of CPA3-positive cells and the platelet count. A positive correlation was found between the number of adjoining MCs, as well as fragments of tryptase-positive MCs, and the erythrocyte sedimentation rate (ESR). A negative correlation was also observed between the number of non-degranulated CPA3-positive MCs and the blood level of C-reactive protein. In patients with COVID-19, reduced degranulation activity of tryptase-positive MCs was found along with increased representation of CPA3positive MCs. Several trends and associations with laboratory test results were noted. The potential involvement of MCs in the development of anemia and thrombocytopenia is considered. Associations were established between tryptase-positive MCs and the peripheral blood counts of leukocytes and eosinophils, as well as ESR.Conclusion. The results obtained are highly contradictory. Since many aspects of the involvement of MCs and their proteases in COVID-19 pathogenesis are still unknown, studies with larger cohorts of patients are needed.
A Case report Abdominal TB presented as right psoas muscle abscess
Authors: A.Abusin Mr.Mohammed , Ali DR.Tagwa , Rajab DR. Mohammed , Omer DR. Elaf , Mohammed DR.Ruba 
Published: February 2023

Psoas muscle abscess is an uncommon presentation of abdominal TB, we described a 55 years old Sudanese male presented with a history of constitutional symptoms and history of right groin mass. Our patient denied any history of TB infection or contact with TB patient. Computed tomography scan revealed a right psoas muscle abscess. A US guided biopsy of the abscess was carried out and sent to histopathology, which showed mycobacterium tuberculosis infection. The patient was treated with antituberculus therapy and an ultrasound guided surgical drainage of the abscess. But our patient then developed signs of acute intestinal obstruction and underwent exploratory laparotomy, in which he was discovered to have a small bowel stricture as a complication of his abdominal TB. ileostomy was done, and a couple of days later the patient was discharged on good medical condition and antituberculus therapy.
Using Refutation Technique to Increase Students’ Reading Comprehension at the Second Grade Students of Sma Hasanuddin Gowa
Authors: Bahang M. Dahlan , Wijaya Iriany Kesuma , HB Lukman 
Published: February 2023

The aims of this study was to find out whether or not refufation technique can increase the students’ reading comprehension of the second grade students of SMA Hasanuddin Gowa. This research employed pre-experimental method which one class was given pre-test, treatment and post-test. The population of this research was the second grade students of SMA Hasanuddin Gowa. The total sample consisted of 24 students and it is used purposive sampling technique. The instrument was reading text in order to measure the students’ reading comprehension skill by using refutation technique. The result of the data showed that by using reputation technique in reading comprehension was effective in improving the students’ reading skill. In other words, the finding indicated that using refutation technique in teaching reading comprehension was able to improve the students’ skill in reading. Based on the result of the data showed that there was a significant difference between the pre-test mean score (45.04), and the post-test mean score (71.83). It can be concluded that the use of refutation technique in reading comprehension can be improved at SMA Hasanuddin Makassar.
Coleção Goiás
Authors: Esbell Jaider 
Published: February 2023

Eis as 7 obras de arte que se tornam 14 e suspensas no ar giram ao infinito. Ou, Escrevo de Roraima numa tarde quente e ventilada quando o mundo está ainda mais incerto e certo de que os céus cairão de vez sobre nossas cabeças e na cabeça dos outros. Na “minha arte” sempre procurei botar feitiços e suas feituras, algo assim, mágico, para despistar as feiuras e bem passar para o além.
The Role of Dual Antiplatelet in Stent-Assisted Coiling in Wide-Neck Aneurysm
Authors: Kurniawan Ricky Gusanto , Prasetyo Bambang Tri , Rilianto Beny , Arham Abrar 
Published: February 2023

Highlight:

Dual antiplatelet is the gold standard for endovascular treatment of wide-neck aneurysms.
The role of dual antiplatelet is to prevent stent thrombosis after treatment.
The thrombosis rate reported during stent-assisted coiling is quite high.

ABSTRACT
Stent-assisted coiling (SAC) in wide-neck aneurysm treatment is associated with antiplatelet use. Dual antiplatelet therapy (DAPT) has been the gold standard for protecting against thrombosis events and is widely accepted for endovascular embolization treatment with a stent-assisted or flow diverter. Some patients experience vascular events due to the reduced efficacy of antiplatelet agents despite taking DAPT. The reported thrombosis rates during stent-assisted coiling embolization range from 2% to 20%. Thromboembolic complications, such as in-stent thrombosis, can manifest in 4.6% of cases. The correlation between platelet reactivity during treatment and bleeding events remains unclear. However, the association between High Residual Platelet Reactivity (HRPR) or hyporesponsiveness and ischemic events is well established. Based on various laboratory definitions, hyperresponsiveness in patients with clopidogrel occurs in about 14–30% of patients due to major and minor bleeding. Therefore, the optimization of antiplatelet therapy has developed significantly in the neurointerventional community.
Classification of Rice Quality Using Backpropagation Based on Shape and Color
Authors: Farisi Olief Ilmandira Ratu , Pratamasunu Gulpi Qorik Oktagalu , Sulaihah Siti 
Published: February 2023

AbstractThe distribution of mixed rice on the market makes it difficult for consumers to determine the rice quality. In determining rice quality, the consumers consider and compare the texture, size, shape, color, aroma, purity, and homogeneity manually. This process is prone to errors and mistakes, due to the limited ability of each human's vision. Therefore, a method to determine the quality of rice automatically based on the physical characteristics of rice is needed. In this paper, we proposed an automatic rice quality classification method using backpropagation based on the shape and color of the rice. There are four parameters used to determine the classification process, namely compactness, circularity, mean, and skewness. Compactness and circularity were used to determine the ratio between the whole rice and the broken rice. While mean and skewness were used to determine the color distribution of the rice. Experiments have been performed on 100 images consisting of 50 premium and 50 medium rice images. The experimental results show that the proposed method can classify rice based on its shape and color effectively with an accuracy rate of 95%.Keywords: rice quality, classification, backpropagation, shape feature, color feature Abstrak[Klasifikasi Kualitas Beras Menggunakan Backpropagation Berdasarkan Bentuk dan Warna] Distribusi beras oplosan di pasaran menyulitkan konsumen dalam menentukan kualitas beras. Konsumen mempertimbangkan dan membandingkan tekstur, ukuran dan bentuk, warna, aroma, kemurnian, dan keseragaman secara manual untuk menentukan kualitas beras. Proses ini rawan terjadi kesalahan dan kekeliruan, karena keterbatasan kemampuan penglihatan setiap manusia. Oleh karena itu diperlukan suatu metode untuk menentukan kualitas beras secara otomatis berdasarkan karakteristik fisik beras. Dalam penelitian ini, kami mengusulkan metode klasifikasi kualitas beras otomatis menggunakan backpropagation berdasarkan bentuk dan warna beras. Ada empat parameter yang digunakan untuk menentukan proses klasifikasi yaitu compactness, circularity, mean, dan skewness. Compactness dan circularity digunakan untuk menentukan perbandingan antara nasi utuh dan nasi pecah. Sedangkan mean dan skewness digunakan untuk menentukan distribusi warna beras. Percobaan telah dilakukan pada 100 citra yang terdiri dari 50 citra beras premium dan 50 citra beras medium. Hasil percobaan menunjukkan bahwa metode yang diusulkan dapat mengklasifikasikan beras berdasarkan bentuk dan warnanya secara efektif dengan tingkat akurasi 95%.Kata kunci: kualitas beras, klasifikasi, backpropagation, fitur bentuk, fitur warna
The effects of lidocaine intravenous infusion on postoperative pain and quality of recovery: What should we expect from a systematic review and Meta-analysis
Authors: Li Fangzhou , Guo Liang , Huang Zijin , Pan Linghui 
Published: February 2023

Abstract
Background: Perioperative intravenous infusion of lidocaine has become part of multimode analgesia in opioid-free anesthesia, which can reduce postoperative pain and improve postoperative recovery quality. However, the results of this discussion are still in dispute. The purpose of this systematic review and meta-analysis was to determine the effect of intravenous lidocaine infusion on postoperative recovery quality and analgesic in adult patients undergoing general anesthesia.
Methods: PubMed, EMBASE, Web of Science database, and Google Scholar were systematically searched for randomized controlled trials, regardless of language and publication platform. A total of 13 randomized controlled trials (1131 patients) were included. The primary outcome measures were the total Quality of Recovery (QoR-40) on the first postoperative day (POD1) and Visual Analogue Scale (VAS) and Numeric Rating Scale (NRS) at different postoperative time points. Secondary outcome measures were the incidence of postoperative nausea or vomiting, time to recovery of intestinal function, and length of hospital stay. Data extraction and bias risk assessment were conducted independently by two researchers.
Results: Systemic intravenous infusion of lidocaine on the first postoperative day(POD1) significantly improved the quality of recovery(QoR-40)(WMD, weighted mean difference 4.98；95%CI, confidence interval 1.78 to 8.19；P value =0.002；heterogeneity, I2=63%), NRS pain scores were significantly decreased at rest and movement at 0.5 h postoperative（Rest status: WMD, -0.70; 95%CI:-1.05~-0.35; P=0.0001; I2=0%）（Movement status: WMD, -0.76；95%CI:-1.18~-0.34; P=0.0004; I2=9%）. There were no significant differences in VAS and NRS pain scores at other time points.
Conclusions: Low-risk bias evidence suggests that intravenous lidocaine improves QoR-40 scores on the first day after general anesthesia and reduces postoperative pain during resuscitation. However, this conclusion needs to be further confirmed by a large number of high-quality randomized controlled trials.
Chromosomal instability in various generations of human mesenchymal stem cells following the therapeutic radiation doses
Authors: Moghadam Majid Sadeghi , Azimian Hosein , Afshari Jalil Tavakol , Toossi Mohammad Taghi Bahreyni , Farkhad Najmeh Kaffash , Aghaee-Bakhtiari Seyed Hamid 
Published: February 2023

Abstract

Background:Radiotherapy is thecrucial treatment for most malignancies, however; it has short and long-term side effects. The occurrence of secondary cancer following radiation-induced genomic instability in stem cells is an important long-term side effect of radiation therapy. The radiation response of human mesenchymal stromal cells (hMSCs) is critical in cancer patients who are treated with radiotherapy for hMSCs lifetime proliferative potential. Evaluation of genomic instability in human mesenchymal stem cells at different radiation doses and times, and examining the relative expression of some effective genes, have been the objectives of this study.Methods:After extraction, characterization, and expansion of hMSCs, they were irradiated for 0, 0.5, 2, and 6 Grays. Nuclear alterations were evaluated at 2, 10, and 15 days after irradiation using the cytokinesis-block micronucleus assay. As well as TP53, Bax, Bcl2, and KRAS gene expressions were analyzed 48 hours post-irradiation for genomic response evaluation.Results:The mean incidence of micronucleus, nucleoplasmic bridges, and nuclear buds incidences were 4.8±1.6, 47.6±6, and 18±2.6, respectively, 48 hours after the fourth passage in the non-irradiated (control) group for one thousand binucleated cells. Micronuclei incidences in 0.5, 2, and 6 grays radiation groups were 14.3±4.9, 32.3±6.5 and 55±9.1 respectively in 48 hours after irradiation and 12.6±1.5, 19±5.5, and 22.3±5.2, respectively ten days post-irradiations. Conclusion: Low levels of nuclear alterations as genomic instability markers were seen in various cell generations of control groups, which must be considered for cell therapy and regenerative medicine applications. In the irradiated groups, chromosomal aberration increased significantly with the dose, 2days post-irradiation due to a disproportionate increase in the Bax/Bcl2 ratio and high expression of the KRAS gene. significant nuclear alterations were seen in the tenth to fifteenth generations of irradiated hMSCs due to radiation-induced genomic instability which may persuade secondary malignancies in the following years after the radiotherapy treatment of patients.
Magnetic and Resistivity Imaging of a probable Fault within the Precambrian Crystalline Rocks in Ogbomoso, Southwestern Nigeria
Authors: Bayowa Oyelowo Gabriel , Fawole Olamide , Olorunfemi Martins Olusola , Ajagbe Sordiq Obafemi , Oni Ademakinwa George , Adelere Isaiah Oluwadara , Ajibade Monsur Olawale , Ajibola Febisola Esther 
Published: February 2023

Abstract
A linear geological structure which is suspected to be a fault within the Precambrian Basement Complex rocks of Ogbomoso, Southwestern Nigeria is found in the geological map of Ogbomoso Southwest Sheet 222. The ground magnetic and electrical resistivity methods were used to investigate the structure and determine its physical characteristics. Five (5) traverses with lengths varying from 700–800 m and trending NNW-SSE (N338oW) were established perpendicularly (ENE-WSW, N68oE) to the suspected fault. Total magnetic field data were acquired at 10 m interval, corrected for diurnal variation and inverted using the Geosoft Oasis Montaj software package. Dipole-Dipole resistivity data were acquired on the traverses using a dipole length of 20 m with expansion factor n varying from 1 to 5 and modelled to generate 2D resistivity structures with the DIPPRO™ software package. Thirty-seven (37) depth sounding data were acquired, quantitatively interpreted and the results used to generate geoelectric sections along the suspected geologic features. Three (3) parallel linear features F1-F1, F2-F2 and F3-F3 characterized by peak negative (-110 to -20 nT) magnetic anomalies typical of thin and thick dykes (in low magnetic latitude) and low resistivity vertical discontinuities (˃ 188 m deep, 30–153 m wide) within 2D resistivity structures, were identified across the five traverses. F1-F1 coincided with the suspected fault, F1-F1. F2-F2 and F3-F3 are parallel and suspected to be syngenetic with F1-F1. The absence of a significant vertical displacement, typical of normal faulting, in the basement bedrock on the 2D geoelectric sections corroborated the inference of strike slip faulting from the geological map.