bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidencia de la gestión talento humano en la calidad de los servicios del GAD municipal del cantón Quevedo durante el periodo 2018 al 2022
Authors: Alvarado Florencia Evelyn Estrella , Castillo Baño Carmen Patricia , Quiñonez Rosado Milena Noemy , Jadán Solís Katty Pilar , Mora Carpio Wendy Tamara 
Published: February 2025

Este estudio se centra en la gestión del talento humano en el Gobierno Autónomo Descentralizado Municipal del cantón Quevedo. El objetivo consistió en Determinar la incidencia de la gestión de talento humano en la calidad de la atención al ciudadano. Se utilizó un enfoque cualitativo basado en la revisión bibliográfica, con un alcance descriptivo y exploratorio, que permitió comprender en profundidad la relación entre la gestión de talento humano y la calidad de los servicios del GAD. Se identificaron aspectos claves como la necesidad de mejorar la formación del personal, optimizar la organización interna y fortalecer la motivación de los empleados. Los resultados obtenidos evidencia que una gestión adecuada del talento humano, optimiza los procesos y recursos, esto se traduce en mayor eficiencia y eficacia en la prestación de servicios. Se resalta que un personal motivado y capacitado es más propenso a proponer nuevas ideas y soluciones para mejorar los servicios e incluso gestionan eficientemente los trámites y solicitudes de los ciudadanos.
Entre nation et région : les collèges classiques et le développement d’une conscience historique au Canada français et en Acadie
Authors: St-Pierre Stéphanie 
Published: February 2025

Les collèges classiques de langue française ont joué un rôle crucial dans l’éducation et la formation identitaire des francophones de l’Acadie et du Canada. Cette note de recherche explore comment ces collèges ont contribué à l’élaboration d’un discours historique porteur d’un sentiment d’appartenance en milieu francophone minoritaire, en examinant trois collèges spécifiques : le Collège du Sacré-Coeur à Sudbury, le Collège de Saint-Boniface au Manitoba, et le Collège Sainte-Anne en Nouvelle-Écosse. Le texte met en lumière comment les activités historiques dans les trois collèges classiques étudiés visent à enraciner la population locale dans leur passé par la promotion d’une conscience historique régionale.
Demyelinating neuropathy as the initial presentation of familial E200K Creutzfeldt–Jakob disease in two patients
Authors: Delorme Cécile , Pégat Antoine , Theuriet Julian , Brandel Jean‐Philippe , Roze Emmanuel , Viala Karine , Zyss Julie , Thobois Stéphane , Fourier Anthony , Bernard Emilien , Svahn Juliette , Laurencin Chloé , Jaulent Paul , Vandendries Christophe , Quadrio Isabelle , Desestret Virginie , Meyronet David , Maisonobe Thierry , Haïk Stéphane , Seilhean Danielle 
Published: January 2025

AbstractObjectiveTo describe peripheral neuropathy associated with familial Creutzfeldt‐Jakob disease.MethodsWe report two unrelated patients with genetic Creutzfeldt–Jakob disease with demyelinating peripheral neuropathy as initial presentation, with a comprehensive clinical, electrophysiological and neuropathological description.ResultsBoth patients exhibited gait disturbance and paresthesia. Electrodiagnostic studies revealed demyelinating abnormalities with motor conduction blocks suggestive of chronic inflammatory demyelinating polyradiculoneuropathy, with abnormal plexus MRI and elevated CSF protein levels. One of them had pes cavus and a late‐onset Charcot–Marie‐Tooth (CMT) disease was also initially hypothesized. Central nervous system involvement manifested 1–2 years after the onset of peripheral symptoms. Both patients had a heterozygous E200K mutation in the PRNP gene. Postmortem neuropathological examinations showed PrPSc deposits in the peripheral nervous system, particularly in Schwann cells. Interpretation: Peripheral neuropathy in E200K genetic forms of Creutzfeldt‐Jakob disease can be inaugural and mimic chronic inflammatory demyelinating polyradiculoneuropathy.
Photothermal Coating on Zinc Alloy for Controlled Biodegradation and Improved Osseointegration
Authors: Hsu Yuchien , He Yunjiao , Zhao Xiao , Wang Feilong , Yang Fan , Zheng Yufeng , Zhou Yongsheng , Xia Dandan , Liu Yunsong 
Published: January 2025

AbstractZinc (Zn) and its alloys are promising biomaterials for orthopedic applications due to their degradability and mechanical properties. Zn2+ plays a crucial role in bone formation, but excessive early release may cause cytotoxicity and inhibit osseointegration. To solve this, we developed a near‐infrared (NIR) light‐controlled polycaprolactone/copper‐sulfur (PCL/CuS) coating that slows degradation and enhances osseointegration of Zn alloys. The zinc–lithium (Zn–Li) substrate is encapsulated with PCL, reducing Zn2+ release and maintaing biocompatibility. Controlled Zn2+ release and mild photothermal therapy via CuS nanoparticles promoted osteogenesis. In vitro studies demonstrated enhanced cell proliferation and osteogenic differentiation. In vivo Micro‐Computed Tomography (Micro‐CT), Scanning Electron Microscopy‐Energy Dispersive Spectroscopy (SEM‐EDS), and immunohistochemical analyses confirmed improved osseointegration. Mechanistic studies using RNA sequencing and Western blotting revealed that the coating promotes osteogenesis by activating the Wnt/β‐catenin and inhibiting NF‐κB pathways. This NIR light‐controlled PCL/CuS coating successfully regulates Zn alloy degradation, enhances osseointegration via controlled Zn2+ release and mild photothermal therapy effct, presenting a promising avenue for orthopedic biomaterials.
Scale‐free Spatio‐temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins
Authors: Song Haoyu , Cui Jian , Hu Guorong , Xiong Long , Wutthinitikornkit Yanee , Lei Hai , Li Jingyuan 
Published: January 2025

AbstractThe self‐assembly of intrinsically disordered proteins (IDPs) into condensed phases and the formation of membrane‐less organelles (MLOs) can be considered as the phenomenon of collective behavior. The conformational dynamics of IDPs are essential for their interactions and the formation of a condensed phase. From a physical perspective, collective behavior and the emergence of phase are associated with long‐range correlations. Here the conformational dynamics of IDPs and the correlations therein are analyzed, using µs‐scale atomistic molecular dynamics (MD) simulations and single‐molecule Förster resonance energy transfer (smFRET) experiments. The existence of typical scale‐free spatio‐temporal correlations in IDP conformational fluctuations is demonstrated. Their conformational evolutions exhibit “1/f noise” power spectra and are accompanied by the appearance of residue domains following a power‐law size distribution. Additionally, the motions of residues present scale‐free behavioral correlation. These scale‐free correlations resemble those in physical systems near critical points, suggesting that IDPs are poised at a critical state. Therefore, IDPs can effectively respond to finite differences in sequence compositions and engender considerable structural heterogeneity which is beneficial for IDP interactions and phase formation.
Facile Ester‐based Phase Change Materials Synthesis for Enhanced Energy Storage Toward Battery Thermal Management
Authors: Geng Long , Luo Kaifeng , Lin Yixuan , Li Guo , Cao Yitong , Zhao Jiateng , Liu Changhui 
Published: January 2025

AbstractWith the increasing demand for thermal management, phase change materials (PCMs) have garnered widespread attention due to their unique advantages in energy storage and temperature regulation. However, traditional PCMs present challenges in modification, with commonly used physical methods facing stability and compatibility issues. This study introduces a simple and effective chemical method by synthesizing seven ester‐based PCMs through chemical reactions involving lauric acid (LA) and seven different alcohols. These materials notably broaden the phase change temperature range, exhibiting melting temperature from −8.99 to 46.60 °C, expanding by 203.18% compared to raw alcohol materials. In addition, these samples exhibit excellent thermal stability and high latent heat, with a maximum latent heat value of 182.98 J g−1. In subsequent application studies, this material demonstrates outstanding energy storage characteristics and proposed an innovative thermal management method for batteries based on the PCM immersion technique, allowing the battery to maintain a temperature below 60 °C for 20.5 h, while the blank group rapidly reached 60 °C within 0.82 h and increased to 75 °C within 2.35 h. This approach greatly improves temperature regulation, enhances battery safety, and boosts operational efficiency, highlighting the immense potential of the material in advanced energy storage applications.
Quantifying Magnetic Anisotropy of Series of Five‐Coordinate CoII Ions: Experimental and Theoretical Insights
Authors: Thangaraj Vijaya , Sartini Daniele , Borah Dipanti , Chauhan Deepanshu , Sharma Vasudha , Sorace Lorenzo , Rajaraman Gopalan , Perfetti Mauro , Shanmugam Maheswaran 
Published: January 2025

AbstractStabilizing large easy‐axis type magnetic anisotropy in molecular complexes is a challenging task, yet it is crucial for the development of information storage devices and applications in molecular spintronics. Achieving this requires a deep understanding of electronic structure and the relationships between structure and properties to develop magneto‐structural correlations that are currently unexplored in the literature. Herein, a series of five‐coordinate distorted square pyramidal CoII complexes [Co(L)(X2)].CHCl3 (where X = Cl (1), Br (2), or I (3)) is reported, all exhibiting easy‐axis magnetic anicotropy. The size of the zero field splitting axial parameter (D) is quantitatively determined (1 = −72; 2 = −67 and 3 = −25 cm−1) using a cantilever torque magnetometry which is further firmly supported by magnetic susceptibility, and EPR measurements. The study of the magnetization relaxation dynamics reveals field‐induced slow relaxation of magnetization due to the predominant Raman relaxation process. Theoretical calculations on 1–3 and optimized model complexes of 1 reveal insights into the electronic structure and highlight the impact of steric and electronic effects on modulating the D values. Overall, the studies reported pave the way for designing a new generation of CoII complexes with enhanced axiality and a lower rhombicity.
Rapid detection of RNase‐based self‐incompatibility in Lysimachia monelli (Primulaceae)
Authors: Ramanauskas Karolis , Jiménez‐López Francisco J. , Sánchez‐Cabrera Mercedes , Escudero Marcial , Ortiz Pedro L. , Arista Montserrat , Igić Boris 
Published: January 2025

AbstractPremisePrimroses famously employ a system that simultaneously expresses distyly and filters out self‐pollen. Other species in the Primulaceae family, including Lysimachia monelli (blue pimpernel), also express self‐incompatibility (SI), but involving a system with distinct features and an unknown molecular genetic basis.MethodsWe utilize a candidate‐based transcriptome sequencing (RNA‐seq) approach, relying on candidate T2/S‐RNase Class III and S‐linked F‐box‐motif‐containing genes and harnessing the unusual evolutionary and genetic features of SI, to examine whether an RNase‐based mechanism underlies SI in L. monelli. We term this approach "SI detection with RNA‐seq" (SIDR).ResultsThe results of sequencing, crossing, population genetics, and molecular evolutionary features each support a causal association linking the recovered genotypes with SI phenotypes. The finding of RNase‐based SI in Primulaceae (Ericales) all but cements the long‐held view that this mechanism was present in the ancestral pentapetal eudicot, whose descendants now comprise two‐thirds of angiosperms. It also significantly narrows the plausible maximum age for the heterostyly evolution within the family.ConclusionsSIDR is powerful, flexible, inexpensive, and most critically enables work in often‐neglected species. It may be used with or without candidate genes to close enormous gaps in understanding the genetic basis of SI and the history of breeding system evolution.
Comparative diversification analyses of Hydrangeaceae and Loasaceae reveal complex evolutionary history as species disperse out of Mesoamerica
Authors: Schenk John J. , Jacobs Sarah , Hufford Larry 
Published: January 2025

AbstractPremiseThe movement of lineages into novel areas can promote ecological opportunity and adaptive radiation, leading to significant species diversity. Not all studies, however, have identified support for ecological opportunity associated with novel intercontinental colonizations. To gain key insights into the drivers of ecological opportunity, we tested whether intercontinental dispersals resulted in ecological opportunity using the Hydrangeaceae‐Loasaceae clade, which has numerous centers of diversity across the globe.MethodsA time‐calibrated phylogeny was reconstructed from four molecular markers. We tested for bursts of speciation rates followed by a decrease as expected phylogenetic patterns under an ecological opportunity model. Ancestral ranges were estimated using historical biogeographic analyses to examine the relationships of ancestral distributions and habitats with speciation and extinction rates.ResultsHydrangeaceae and Loasaceae originated in arid Mesoamerica, then dispersed into South America, Eurasia, and eastern North America. Six clades experienced increased diversification rates, but those increases were not associated with transitions into new continental areas. Mentzelia section Bartonia was the only clade that exhibited a burst of speciation followed by a decrease. Both families originated in arid environments and experienced multiple transitions into mesic and tropical environments, but Loasaceae experienced a higher speciation‐to‐extinction ratio than Hydrangeaceae in the western Nearctic.ConclusionsDispersal between continents did not trigger speciation rate shifts in Loasaceae and Hydrangeaceae. Instead, shifts occurred in regions inhabited by intrafamilial relatives and were likely driven by climate change in the Miocene, where species in drier microhabitats diversified into newly created habitats.
Coordination Bond‐Based Nanosystems for Manipulating Niche Framework in Biomedical Applications
Authors: Salvi Bhagyashree V. , Shende Pravin 
Published: January 2025

ABSTRACTThe extensive connectivity between organic ligands and inorganic metal ions enables precise design and physicochemical modification of metal–organic frameworks (MOFs) for various applications. The metal‐based counterparts, nanoscale metal–organic frameworks (nMOFs), are among advanced classes of hybrid nanoparticles, with the fundamental characteristics of pristine MOFs and nanoscale dimensions that enhance their potential for clinical applications. The distinct structure, pore size tunability, easy surface functionalization, large surface area, and porosity enable loading of various therapeutic and imaging agents. In addition, nMOFs demonstrate biocompatibility, multifunctionality, and the relatively labile metal–ligand bonds impart biodegradability. Owing to such excellent properties, nMOFs exhibits biomedically relevant applications as therapeutic cargoes, bioimaging, biosensing and biocatalysts agents. This article elucidates the advantages of nMOFs over other existing nanocarriers (e.g., organic and inorganic) and focuses on new insights of synthesis, design strategies with surface modification techniques for hybrid material development. The biomedical applications with futuristic approach are discussed with relevant examples in detail to inspire further exploration of nMOFs as biomedically relevant agents with great market potential in biomedical sciences.
Synthesis, Antioxidant, and Antidiabetic Potential of Ferrocenylmethylnucleobase Compounds: In Vitro, In Silico Molecular Docking, DFT Calculation, and Molecular Dynamic Simulations
Authors: Adaika Aicha , Bekkar Yahia , Youmbai Souhir , Bourougaa Lotfi , Lanez Elhafnaoui , Ben Amor Mohammed Larbi , Nesba Kaouther , Lanez Touhami , Bechki Lazhar 
Published: January 2025

ABSTRACTThis study presents the synthesis and characterization of a novel series of ferrocenylmethylnucleobase compounds, namely, FcMeAd, FcMeCy, FcMeTh, and (FcMe)₂Ad with promising antioxidant and antidiabetic properties. Spectroscopic techniques confirmed their sandwich‐like geometry, with the nucleobase moiety coordinated to the ferrocene unit. Density functional theory (DFT) optimization revealed alignment with existing crystallographic data and indicated low frontier molecular orbital (FMO) energy gaps, suggesting facile intramolecular charge transfer and potential biological activity. The antidiabetic activity was evaluated in vitro through inhibition assays targeting α‐glucosidase and α‐amylase enzymes, which was supported by in silico molecular docking studies. Among the compounds, FcMeTh exhibited the highest antidiabetic and antioxidant properties due to the presence of carbonyl and amide functionalities, along with an electron‐donating methyl group. Molecular dynamics (MD) simulations confirmed high binding affinity and structural stability of the docked compounds, with strong interactions with the target enzymes, further validating the potential of these compounds as effective inhibitors. Pharmacokinetic and ADMET evaluations indicated their nontoxic, noncarcinogenic nature and suitability for oral administration. The combined in vitro and in silico findings, including the critical insights from MD simulations, suggest that these ferrocenylmethylnucleobase compounds, especially FcMeTh, possess enhanced antioxidant and antidiabetic properties. This highlights their potential as promising therapeutic agents for managing oxidative stress and Type 2 diabetes.
Understanding ASEAN Centrality: Comparative Analysis of ‘Core’ and ‘Hub’ Strategies
Authors: Hamanaka Shintaro 
Published: January 2025

ABSTRACTASEAN centrality is a term that has emerged in the recent literature on international relations and institutions focussing on the region surrounding ASEAN. It refers to the idea that ASEAN has or should have a central role in forming the political and economic institutional architecture of a wider region. Unfortunately, however, previous studies have failed to identify whether ASEAN has centrality or not. There are two problems. First, the concept of centrality is vague. Second, a sound method to assess the centrality is absent. This study attempts to contribute to the literature mainly from theoretical (conceptual) and, to a lesser degree, empirical perspectives. From the theory front, the paper elaborates the notion of centrality, by differentiating the two concepts related to centrality: core and hub. From the empirical front, the paper claims the usefulness of comparative analysis. Even if the level of centrality cannot be measured, we can better assess whether ASEAN hold the core and/or hub status in regional institutional architecture, if it is compared with other institutions.
The Elite Paradigm Driving Australian Aid Policy: Learning to Live With the ‘Cautious Consensus’
Authors: Day Benjamin , Wells Tamas 
Published: January 2025

ABSTRACTThis article explores the underlying reasons for why the Albanese Labor Governmentʼs stated policy ambition to ‘rebuild Australiaʼs international development program’ has not yet been accomplished and is unlikely to be realised, at least in the near‐to‐medium term. Based on interviews conducted with 21 Australian Members of Parliament, we find that the ‘cautious consensus’—a collection of ideas guiding elite perspectives on Australian aid policy that emerged during the COVID‐19 pandemic—has rapidly consolidated, to the point where it can now be considered a paradigm. We identify three main factors that have led to this consolidation: the declining salience of aid; growing elite scepticism about the usefulness of aid; and a combination of political challenges that are difficult for Labor to navigate, as it seeks to become a long‐term Government. Given the prospects of shifting the unambitious status quo are unlikely in the in the near‐to‐medium term, we examine what ‘living with the cautious consensus’ means for the Australian development sector.
Predefined time trajectory tracking control and hardware in loop verification for quadrotor UAV under input delay and disturbances
Authors: Li Shuo , Duan Na , Pei Hailong 
Published: January 2025

AbstractThis paper deals with the predefined time trajectory tracking control of quadrotor unmanned aerial vehicle (UAV) system in the presence of input delay and external disturbances. By combining the backstepping with the predefined time nonlinear disturbance observer, the uncertainty caused by the external disturbance is eliminated, enabling the UAV to reach the control target within a predefined time. Moreover, in order to compensate for the impact of the control input delay, an appropriate auxiliary system is introduced. Simulation and hardware‐in‐the‐loop (HIL) experimental are carried out to show the effectiveness of the proposed control scheme.
Neural electrodes for brain‐computer interface system: From rigid to soft
Authors: Yang Dan , Tian Gongwei , Chen Jianhui , Liu Yan , Fatima Esha , Qiu Jichuan , Malek Nik Ahmad Nizam Nik , Qi Dianpeng 
Published: January 2025

AbstractBrain‐computer interface (BCI) is an advanced technology that establishes a direct connection between the brain and external devices, enabling high‐speed and real‐time information exchange. In BCI systems, electrodes are key interface devices responsible for transmitting signals between the brain and external devices, including recording electrophysiological signals and electrically stimulating nerves. Early BCI electrodes were mainly composed of rigid materials. The mismatch in Young's modulus between rigid electrodes and soft biological tissue can lead to rejection reactions within the biological system, resulting in electrode failure. Furthermore, rigid electrodes are prone to damaging biological tissues during implantation and use. Recently, flexible electrodes have garnered attention in the field of brain science research due to their better adaptability to the softness and curvature of the brain. The design of flexible electrodes can effectively reduce mechanical damage to neural tissue and improve the accuracy and stability of signal transmission, providing new tools and methods for exploring brain function mechanisms and developing novel neural interface technologies. Here, we review the research advancements in neural electrodes for BCI systems. This paper emphasizes the importance of neural electrodes in BCI systems, discusses the limitations of traditional rigid neural electrodes, and introduces various types of flexible neural electrodes in detail. In addition, we also explore practical application scenarios and future development trends of BCI electrode technology, aiming to offer valuable insights for enhancing the performance and user experience of BCI systems.