bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel use of structural equation modelling to examine diet and metabolic traits associated with microvascular endothelial dysfunction in middle-aged Chinese males: a cross-sectional study
Authors: Miao Rujia , Yu Renhe , Zhou Hui , Liu Lei , Peng Ting , Wang Jiangang 
Published: September 2023

BackgroundThe present study aims to use structural equation modelling (SEM) with multiple regression pathways to examine direct and indirect links from diet and metabolic traits to microvascular endothelial dysfunction (ED) among middle-aged Chinese males.MethodsThe study was conducted in middle-aged Chinese males, who underwent a health check-up between 2018 and 2019. Data on lifestyle behaviour factors (physical activity, diet pattern, sleep quality and diet data underwent factor analysis in advance) and metabolic risk factors referring to metabolic traits were introduced into the SEM to examine inter-relationship among these factors and their association with ED, as evaluated by the reactive hyperaemia index (RHI).ResultsBoth exploratory factor analysis and confirmatory factor analysis identified two major dietary patterns: ‘prudent pattern’ and ‘western pattern’. The univariate test suggested that only triglycerides (TGs) and prudent dietary pattern were directly associated with RHI. Furthermore, prudent dietary pattern had an indirect association with RHI via TG (prudent diet→TG: β=−0.15, p<0.05; TG→RHI: β=−0.17, p<0.001). As to confirming the hypothesised association between variables apart, physical activity frequency was correlated to the decrease in TG (β=−0.29, p<0.001), but had no direct correlation to RHI.ConclusionThe network of direct and indirect associations among diet pattern and cardiometabolic risk factors with RHI measured ED among middle-aged males. The most significant modifiable factors identified were TG and prudent diet pattern, which needs to be targeted as preventive strategies for early microvascular impairment.
Using telemedicine to improve early medical abortion at home (UTAH): a randomised controlled trial to compare telemedicine with in-person consultation for early medical abortion
Authors: Reynolds-Wright John Joseph , Norrie John , Cameron Sharon Tracey 
Published: September 2023

ObjectivesTo compare telephone consultations with in-person consultations for the provision of medical abortion (using mifepristone 200 mg and misoprostol 800 µg). We hypothesised that telemedicine consultations would be non-inferior to in-person consultations with a non-inferiority limit of 3%.DesignRandomised controlled trial with 1:1 allocation.SettingCommunity abortion service housed within an integrated sexual and reproductive health service in Edinburgh, UK.ParticipantsThe trial began on 13 January 2020, but was stopped early due to COVID-19; recruitment was suspended on 31 March 2020, and was formally closed on 31 August 2021. A total of 125 participants were randomised, approximately 10% of the total planned, with 63 assigned to telemedicine and 62 to in-person consultation.Primary and secondary outcome measuresPrimary outcome: efficacy of medical abortion, defined as complete abortion without surgical intervention. Secondary outcomes: satisfaction with consultation type, preparedness, unscheduled contact with care, complication rate, time spent in clinical contact and uptake of long-acting contraception.ResultsPrimary outcome was available for 115 participants (lost-to-follow-up telemedicine=2, in-person=8), secondary outcomes were available for 110 participants (n=5 and n=10 in telemedicine and in-person groups did not complete questionnaires). There were no significant differences between groups in treatment efficacy (telemedicine 57/63 (90.5%), in-person 48/62 (77.4%)). However, non-inferiority was not demonstrated (+3.3% in favour of telemedicine, CI −6.6% to +13.3%, lower than non-inferiority margin). There were no significant differences in most secondary outcomes, however, there was more unscheduled contact with care in the telemedicine group (12 (19%) vs 3 (5%), p=0.01). The overall time spent in clinical contact was statistically significantly lower in the telemedicine group (mean 94 (SD 24) vs 111 (24) min, p=0.0005).ConclusionsTelemedicine for medical abortion appeared to be effective, safe and acceptable to women, with less time spent in the clinic. However, due to the small sample size resulting from early cessation, the study was underpowered to confirm this conclusion. These findings warrant further investigation in larger scale studies.Trial registration numberNCT04139382.
Exploring subjective responses in high-intensity multimodal training: an online cross-sectional survey
Authors: Sharp Tijana , Grandou Clementine , Coutts Aaron J , Wallace Lee 
Published: September 2023

ObjectivesThe purpose of this study was to investigate exercise enjoyment in high-intensity multimodal training (HIMT) in current and previous HIMT participants and identify factors associated with HIMT that mediate exercise enjoyment and motivation.Design and settingA 124-item web-based survey was distributed to a cross-sectional voluntary convenience sample from August to the end of September 2021.ParticipantsGlobal current and previous HIMT participants.ResultsThe final sample included 469 responses (completion rate: 61.6%). Among eligible respondents (n=434), 379 were current HIMT participants, 55 were previous HIMT participants. Current participants demonstrated high enjoyment (Physical Activity Enjoyment Scale). The most frequently reported reasons for increased enjoyment and motivation to continue HIMT in current participants included (1)it keeps me fit,(2)training in a groupand (3)variety in a session. The most frequently reported reasons for reduced motivation to continue HIMT among previous HIMT participants included (1)other (injury, COVID-19 restrictions, low motivation, personal preferences), (2)work commitmentsand (3)I started another type of sport, exercise or training.ConclusionsThese findings indicate that HIMT is an enjoyable training method among current participants. The most commonly reported reasons for increased enjoyment and motivation were associated with the combined training method and the group environment. Reasons for reduced motivation to continue HIMT among previous HIMT participants may be related to commonly reported barriers to exercise and personal factors.
Association between post-COVID-19 status and perioperative morbidity and mortality: protocol for an ambispective cohort study
Authors: Che Lu , Yu Jiawen , Bai Xue , Wang Yi , Zhang Yuelun , Xu Li , Shen Le , Huang Yuguang 
Published: September 2023

IntroductionWith COVID-19 bringing persistent impact on the worldwide population, perioperative management after SARS-CoV-2 infection needs to be revisited in the new period of different circulating coronavirus variants, vaccination status, increased reinfection rate and new disease control policies. This study aims to explore the association between time to surgery after COVID-19 diagnosis and the risk of postoperative morbidity and mortality.Methods and analysisThis is a single-centre ambispective cohort study. Patients with preoperative SARS-CoV-2 infection who require inpatient surgical intervention from 1 December 2022 to 28 February 2023 will be included. Baseline assessment will include the time interval between preoperative SARS-CoV-2 infection and surgery, COVID-19 diagnosis and symptoms, vaccination status and routine preoperative evaluations. The primary outcome will be postoperative composite complications within 30 days after surgery. Association between post-COVID-19 interval and the outcomes will be explored using logistic regression after adjusting for confounding variables.Ethics and disseminationThe study protocol has been approved by the Research Ethics Committee of Peking Union Medical College Hospital (IRB K3570). We aim to publish and disseminate the findings in peer-reviewed journals, scientific conferences and on social media.Trial registration numberNCT05689840.
Perception and clinical practice regarding mucus clearance devices with chronic obstructive pulmonary disease: a cross-sectional study of healthcare providers in Saudi Arabia
Authors: Alghamdi Saeed Mardy , Alzahrani Abdulaziz , Alshahrani Yousef M , Al Ruwaithi Abdulhadi A , Aldhahir Abdulelah Mastour , Alsulayyim Abdullah S , Siraj Rayan A , Almansour Abdulelah H , Alasmari Ali M , Alqahtani Jaber S , Alanazi Abdullah M , Jaishi Siraj T , Allehyani Badr A , Hopkinson Nicholas S 
Published: September 2023

ObjectivesClearing secretions from the airway can be difficult for people with chronic obstructive pulmonary disease (COPD). Mucus clearance devices (MCDs) are an option in disease management to help with this, but healthcare provider awareness and knowledge about them as well as current clinical practice in Saudi Arabia are not known.DesignA cross-sectional online survey consisting of four themes; demographics, awareness, recommendations and clinical practice, for MCDs with COPD patients.SettingSaudi Arabia.Participants1188 healthcare providers including general practitioners, family physicians, pulmonologists, nursing staff, respiratory therapists and physiotherapists.Primary outcome measuresHealthcare providers’ level of awareness about MCDs, and the identification of current clinical practices of COPD care in Saudi Arabia.Results1188 healthcare providers (44.4% female) completed the survey. Regarding devices, 54.2% were aware of the Flutter, 23.8% the Acapella and 5.4% the positive expiratory pressure mask. 40.7% of the respondents identified the Acapella, and 22.3% the Flutter as first choice for COPD management. 75% would usually or always consider their use in COPD patients reporting daily difficulty clearing mucus, whereas 55.9% would sometimes or usually consider the use of MCDs with COPD patients who produced and were able to clear mucus with cough. In clinical practice, 380 (32%) of the respondents would prescribe MCDs, 378 (31.8%) would give MCDs without prescriptions, 314 (26.4%) would not provide them at all and 116 (9.8%) would only advise patients about them.ConclusionHealthcare providers are aware of the existence of MCDs and their benefits for sputum clearance and believe that MCDs are beneficial for sputum clearance in some COPD patients.
Assisted Reproductive Technologies (ART) Failures: Is It the Seed or the Soil?
Authors: Sean Sokteang , Tran Chloe , Ou Pichetra , Ouk Chanpisey , Ayoubi Jean Marc , de Ziegler Dominique 
Published: September 2023

Assisted reproductive technologies (ART) have accomplished spectacular progresses over the last few years, leading to sustained implantation rates (sIR) [Formula: see text]60% following euploid blastocyst transfers. These results raise new challenges for infertility specialists, notably the ability to care for infertile couples who fail ART, sometimes recurrently. ART failures may be due to disorders residing in the endometrium (the soil) or embryo (seed). To simplify the review of this dilemma and limit variables, we focused our research on the outcome of euploid blastocysts transfers conducted in E2 and i.m. progesterone replacement cycles. This methodological choice for our research should not be confused with a therapeutic recommendation in case of ART failures. The sum of the data collected indicates that if recurrent implantation failure (RIF) exists, it is extremely rare, affecting only [Formula: see text]5% of ART couples.
Intervenções contemporâneas em diálogo com os valores de tombamento de Goiás (GO)
Authors: Oliveira Karine Camila 
Published: September 2023

Este trabalho analisa as interfaces que duas intervenções em imóveis integrantes do conjunto arquitetônico e urbanístico da cidade de Goiás/GOestabelecem com os fundamentos e valores mobilizados pelo tombamento, em especial, pela rerratificação do tombamento no ano de 2004. As intervenções estudadas foram realizadas através do Programa de Aceleração do Crescimento Cidades Históricas (PAC–CH) entre os anos 2014–2017. Ao alterar um tombamento urbano, modificando seu perímetro, são compreendidos novos valores, que, por sua vez, refletem os novos e atuais sentidos da preservação de determinado bem cultural. No escopo das políticas públicas de preservação, o PAC–CH realizou investimentos de grande ordem em seis obras em Goiás, entre imóveis, áreas públicas e infraestrutura. Portanto, cabe investigar se essas ações recentes e importantes, independentemente de quaisquer categorias de intervenção em bens culturais, estão alinhavadas com as narrativas e premissas contemporâneas que foram identificadas com os valores do tombamento. Foram escolhidas as obras do Mercado Municipal e do Cine Teatro São Joaquim, considerando serem intervenções de maior impacto — financeiro, arquitetônico, urbanístico — no conjunto protegido.
Globalization, Foreign Direct Investment, and Climate Change
Authors: Mejia Steven A. 
Published: September 2023

Abstract
There has been a dramatic increase in the long-term accumulation of foreign direct investment (FDI) in less-developed countries from 1980–2018. Scholars argue that these processes have harmful effects on climate change-inducing emissions. Here, the author argues that such expansions have beneficial impacts. He empirically evaluates such theorization using fixed effects (FE) panel regression models. Results provide support for his view. These results suggest that the long-term accumulation of foreign direct investment in less-developed countries has beneficial implications for the scale, intensity, and ecoefficiency of carbon dioxide emissions.
Footprints: A Digital Approach to (Jewish) Book History
Authors: Margolis Michelle , Lehman Marjorie , Shear Adam , Teplitsky Joshua 
Published: September 2023

Abstract
This article describes and analyzes the methods of Footprints: Jewish Books Through Time and Place, a digital humanities contribution to book history. Footprints collects and aggregates information about the movement of copies of Hebrew books and books of Judaica in other languages printed in the early modern period (roughly corresponding to the hand-press era) and follows evidence of their movement into the twenty-first century. It stores this information in a relational database in which users can run specific queries and delivers the results in a number of visual representations for analysis and interpretation. Footprints undertakes two concurrent and more open-ended aims: (1) the on-going assemblage of a dataset about post-print mobility based on evidence other than the printed text (e.g. marginalia, catalog records, archival letters, other printed texts); and (2) the creation and iterative refining of a scholarly instrument to analyze the dataset through computational methods and modes of representation.
Tax evasion and governance quality: The moderating role of adopting open government
Authors: Khaltar Odkhuu 
Published: September 2023

One of the reasons why many developing countries struggle to provide basic public services to citizens is a lack of tax revenue owing to corruption and illicit financial outflow transfers. Trade misinvoicing is one of the main channels taxpayers use to evade taxes and transfer money abroad, particularly in developing countries. Although scholars have been cognizant of the gravity of corruption, little empirical evidence exists on tax evasion through trade, which is mostly related to the decline of tax revenues in developing countries. To bridge this research gap, this study examines the impact of governance quality and adoption of the Open Government Partnership on trade-related tax evasion in developing countries. Governance quality and open government initiatives are expected to reduce tax evasion by increasing moral cost and transparency, improving the legitimacy of tax burden and tax expenditure. The results show that government effectiveness, regulatory quality, control of corruption, and adoption of open government contribute to combating trade-related tax evasion. Moreover, the government's adoption of an open government moderates the association between governance quality (regulatory quality) and trade-related tax evasion; that is, governance quality significantly impacts reducing tax evasion in countries where open government initiatives are more prevalent. This study holds several implications for leveraging the nationwide adoption of open government, which may directly and indirectly help governments reduce trade-related tax fraud and improve tax revenue. Points for practitioners Governance quality and the adoption of open government initiatives effectively reduce trade-related tax evasion. The impact of governance quality on reducing tax evasion can be enforced by adopting open government partnership.
Employment Dynamics Among Adult Children at the Onset of Parental Dementia: Variation by Sociodemographic Characteristics
Authors: Stokes Jeffrey E. , Kindratt Tiffany B. , Antonucci Toni C. , Cox Chelsea G. , Choi HwaJung 
Published: September 2023

Objectives To examine the influence of sociodemographic factors on employment changes among adult children following onset of parental Alzheimer’s disease and related dementia (ADRD). Methods We used Health and Retirement Study (2010–2018; N = 20,110) data to examine adult child (ages 50–70) changes in employment and work hours at onset of parental ADRD and potential variation by gender, age, race, ethnicity, and education. Results Parental ADRD onset was not associated with changes in adult child employment overall, although associations differed substantially across subpopulations defined by education level. Sons with the lowest education were least likely to cease employment, while daughters with the lowest education were most likely to reduce work hours. Sons at older ages were increasingly likely to reduce work hours or end employment following parental ADRD onset. Discussion The potential impact of parental ADRD on adult child employment is complex and should be considered in the context of sociodemographic factors.
Construction and Statistical Validation of a Path Model of the Factors Influencing Non-suicidal Self Injury (NSSI) among Female Adolescents
Authors: Chakraborty Aparajita , Dogra Atanu Kumar , Paul Ruby , Mukherjee Anindita , Karmakar Asmita , Saha Asoke Kumar , Bhattacharya Jishnu 
Published: September 2023

Introduction: Despite having innumerable literatures, there has been dearth of comprehensive model of the manifestation of non-suicidal self-injury (NSSI). Aim and Objectives: The current study aims to construct a statistically validated model to explore the theoretical connections and the pathway to NSSI among female adolescents. Material and Method: A model was proposed based on the constructs empirically associated with NSSI. The research aims to explore the direct effects of external shame, hated self, and self-compassion on NSSI, and whether this relationship is mediated by borderline personality traits and menstrual phase. A total of 168 female adolescents completed the survey, including informed assent from the adolescents. The Other as Shamer Scale-2, the Forms of Self-Criticism/Self-Reassuring Scale, Self-Compassion Scale, the Risk-Taking and Self-Harm Inventory for Adolescents, and Borderline Personality Features Scale for Children were administered to the participants. Analysis of data involved descriptive statistics and path analysis. Result: The pathway shows hated self, disturbed intrapersonal relationship, and the inability to direct compassion for self may increase NSSI. Borderline personality traits and premenstrual dysphoria form indirect but contributory factors to strengthen the association between internal traits and NSSI. Conclusion: Thus it may be concluded from the present finding that external shame has significant negative effect on self-compassion and external shame has a significant positive effect on hated self. Also, self-compassion has a significant negative effect, and hated self as well external shame have significant positive effects on borderline traits. Thus, exploring this path would help to plan a suitable preventive action.
Immune-mediated colitis associated with ocrelizumab: A new safety risk
Authors: Kim Tiffany , Brinker Allen , Croteau David , Lee Paul R , Baldassari Laura E , Stevens Jessica , Hughes Alice , Tomaino Juli , deFonseka Arushi , Altepeter Tara , Kortepeter Cindy M 
Published: September 2023

Background: An association between certain immunomodulatory therapies (rituximab, ipilimumab, and other immune checkpoint inhibitors) and inflammatory (non-ischemic and non-infectious) colitis in oncologic and non-oncologic patient populations is well documented in the medical literature. Objective: The purpose of this case series is to describe adverse event reports of new onset, inflammatory colitis in association with ocrelizumab in patients with multiple sclerosis submitted to U.S. Food and Drug Administration (FDA) or published in the medical literature. Methods: The FDA Adverse Event Reporting System (FAERS) and medical literature were searched. Results: A review of postmarketing cases from FAERS and published medical literature identified 38 cases consistent with inflammatory, non-ischemic, and non-infectious colitis in association with ocrelizumab. The median time-to-onset was 8 months. Cases were reported using the following diagnostic terms: Crohn’s disease (13), unspecified colitis (11), microscopic colitis (5), ulcerative colitis (5), medication-induced colitis (3), and autoimmune colitis (2). Conclusions: This case series highlights ocrelizumab induced immune-mediated colitis that can be clinically severe and potentially life-threatening. Based on the findings of this review, the ocrelizumab Prescribing Information was amended to include immune-mediated colitis in the Warnings and Precautions section.
Does who you live with matter for your health? The influence of partners’ socioeconomic characteristics on self-rated health in Norway
Authors: Hofoss Dag , Grøtvedt Liv , Grøholt Else K. , Ramm Jorun , Lunde Elin S. , Syse Astri 
Published: September 2023

Aims: Studies of the association between self-rated health and persons’ income and education have almost invariably shown that people with higher education and incomes report better health. Less is known of the influence of household members’ socioeconomic characteristics on individuals’ health. This study thus aimed to assess the extent to which the socioeconomic characteristics of partners may contribute to explaining the variation in the respondents’ self-rated health (SRH). Methods: Using an observational design, we analysed cross-sectional Norwegian survey data on SRH (2015 and 2019), linked to register data on education and income for respondents ( N = 7082) and their opposite-sex coresident spouse or partner. We employed logistic regression models to assess the associations between respondents’ SRH and the relative income and education of their partner. Average marginal effects were calculated to enable cross-model comparisons. Results: Net of individual characteristics, having a higher-educated partner was positively associated with SRH for both male (OR = 1.56) and female (OR = 1.36) respondents. Having a partner with an above median income (by age and sex) was positively associated with SRH for female (OR = 1.29) respondents only. For education, the positive SRH associations were roughly similar for respondents and partners. For income, the associations were more pronounced for respondents than partners. Conclusions: Our findings suggest that health is affected by the resources (or lack thereof) in one’s immediate networks. To reduce social inequalities in health, health personnel might customise interactions to account for household resources. Such knowledge could also be used in health-promoting activities to enhance participation and health competency.