bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between Tissue Doppler-derived left ventricular systolic velocity (mitral S’) and left ventricle ejection fraction (LVEF) in sepsis and septic shock: A retrospective cohort study
Authors: Chawla Sanchit , Sato Ryota , Duggal Abhijit , Alwakeel Mahmoud , Hasegawa Daisuke , Alayan Dina , Collier Patrick , Sanfilippo Filippo , Lanspa Michael , Dugar Siddharth 
Published: March 2023

Abstract
Background
Tissue Doppler-derived left ventricular systolic velocity (mitral S’) has shown excellent correlation to left ventricular ejection fraction (LVEF) in non-critically patients. However, their correlation in septic patients remains poorly understood and its impact on mortality is undetermined. We investigated the relationship between mitral S’ and LVEF in a large cohort of critically-ill septic patients.
Methods
We conducted a retrospective cohort study between 01/2011 and 12/2020. All adult patients (≥ 18 years) who were admitted to the medical intensive care unit (MICU) with sepsis and septic shock that underwent a transthoracic echocardiogram (TTE) within 72 hours were included. Pearson correlation test was used to assess correlation between average MASV and LVEF. Pearson correlation was used to assess correlation between average mitral S’ and LVEF. We also assessed the association between mitral S’, LVEF and 28-day mortality
Results
2,519 patients met the inclusion criteria. The study population included 1,216 (48.3%) males with a median age of 64 (IQR: 53–73), and a median APACHE III score of 85 (IQR: 67, 108). The median septal, lateral, and average MASV were 8 cm/sec (IQR): 6.0, 10.0], 9 cm/sec (IQR: 6.0, 10.0), and 8.5 cm/sec (IQR: 6.5, 10.5) respectively. MASV noted to have moderate correlation with LVEF (r = 0.46). In multivariable logistic regression analysis, average MASV was associated with an increase in both 28-day ICU and in-hospital mortality with odds ratio (OR) 1.04 (95% CI: 1.01–1.08, p = 0.02) and OR 1.04 (95% CI: 1.01–1.07, p = 0.02) respectively.
Conclusion
Even though MASV and LVEF may be related, they are not exchangeable and were only found to have moderate correlation in this study. LVEF is U-shaped, while MASV has a linear relation with 28-day ICU mortality. An increase in average mitral S’ was associated with higher 28-day mortality.
Description of the echolocation pulses of insectivorous bats with new records for southwest Colombia
Authors: Arévalo-Cortés Johana , Tulcan-Flores John , Zurc Danny , Montenegro-Muñoz Silvia A. , Calderón-Leytón Jhon Jairo , Fernández-Gómez Ronald A. 
Published: March 2023

Abstract
Diversity surveys may be performed by different sampling methods. In the case of bats, the use of traditional methods such as mist nets, harp traps, and roost detection have limitations in widely covering the diversity in a landscape. Most registered species are restricted to species that forage at the undergrowth or in enclosed spaces. However, acoustic monitoring is complementary to conventional methods and can help obtain more complete bat inventories while avoiding alterations in usual foraging activities and disruption in their life cycles. This study describes the acoustic parameters (spectral and temporal variables) of the echolocation pulses of insectivorous bats to characterise acoustically different species of bats present in southwest Colombia. We recorded echolocation calls between December 2017 and May 2020 in the Andean and Pacific regions of the department of Nariño. A total of 81 sequences from free-flying bats were analysed from eight species belonging to three families: Vespertilionidae, Molossidae and Emballonuridae. Myotis riparius and Lasiurus blossevillii were registered for the first time in Nariño Department. The species M. albescens, M. keaysi, M. riparius and L. blossevillii (Vespertilionidae) had pulses of frequency modulated with a quasi-constant ending; Molossus molossus, Tadarida brasiliensis and Promops centralis (Molossidae) had pulses with constant and quasi-constant frequencies; and Saccopteryx bilineata (Emballonuridae) had pulses with quasi-constant frequencies. This study enriches the efforts to solve acoustic species classification issues of insectivorous bats in the Neotropics.
RNA- Seq analysis of Taverniera cuneifolia (Roth) Ali.
Authors: Momin Talibali , Puvar Apurvasinh , Zala Harshvardhan , Ayachit Garima , Joshi Madhvi , Nagar Padamnabhi 
Published: March 2023

Abstract

Aims: To unravel the potential of Taverniera cuneifoliain transcriptomics
Methods: RNA Seq experiment was conducted using NGS to understand the key metabolites and genes from Taverniera cuneifolia(Roth) Ali.
Key results: 7.29 Gb of raw data and generated 5,59,91,233 raw reads. The high-quality reads were de novo assembled by Trinity assembler followed through CD-HIT resulted into 35,590 Unigene with an average of 419 bp. The unigenes analyzed using BLAST2GO resulted in 27884 (78.35%) transcripts with blast hits, 22510 (63.25%) transcripts with mapping and 21066 (59.19%) transcripts with annotation. Functional annotation was carried out using NCBI non-redundant and Uniprot databases resulted in the identification of 21066 (59.19%) annotated transcripts and GO assigned to 24751 (69.54%) transcripts. The gene ontology result shows maximum sequences match with Biological Processes (48%) Molecular Function (27%) and Cellular components (23%). A total of 179 metabolic enriched pathways were identified which included pathways like Sesquiterpenoid and triterpenoid pathway which were involved in synthesis of important secondary metabolite Glycyrrhizin biosynthesis. Transcription factors were predicted by comparison with Plant Transcription Factor Database and 1557 transcripts belonging to 85 transcription factor families were identified.
Conclusions: This transcriptome analysis provided an important resource for future genomic studies in Taverniera cuneifolia., besides identifying functional secondary metabolites genes of Taverniera cuneifolia with Pharmacological potential for future functional genomics and metabolomic engineering of secondary metabolites form these plants towards diversified industrial applications.
Implications: The study confirms that presence of glycyrrhizin producing genes with six key genes that are backbone of sesquiterpenoid biosynthesis pathway in Taverniera cuneifolia.
Significance
Licorice (Glycyrrhiza glabra roots) is used as traditional Chinese herbal medicines in majority of formulations. Licorice is also used in Industries like food, herbal and cosmetics etc. due to its high demand in the market it is imported from foreign countries and is not available locally of superior quality (Y. Liu et al., 2015). In India, Taverniera cuneifolia has been described as a potent substitute of Licorice, it has been quoted in ancient books like Charak Samhita during the Nigandu period (Pal & Shukla, 2003) and Barda dungar ni Vanaspati ane upyog (Indraji, 1910). It has been used as an expectorant, anti-inflammatory, anti-ulcer, wound healing, blood purifier etc. Transcriptomic studies will assist in understanding the basic molecular structure, function and organization of information within the genome of Taverniera cuniefolia. This study will help us to identify the key metabolites their expressions and genes responsible for their production.
Assessment of Halon-free agents for fire safety application in aircraft propulsion system
Authors: Dinesh Akhil , Diakostefanis Michael , Sampath Suresh 
Published: March 2023

Abstract
Halon 1301 is an effective total flooding fire suppression agent which is widely employed in aircraft cargo and propulsion systems for emergency fire scenarios. The production of Halon 1301 was banned by the Montreal Protocol in 1994 due to its environmental impact on ozone depletion and long atmospheric lifetime. Thus, a credible alternative is required for fire safety application on-board aircrafts. This study forms a follow-up to the work published by A. Dinesh et.al [14] and M. Diakostefanis et.al [16] which studied halon-free fire suppression in aircraft cargo bay through CFD and experimental validation respectively. Due to constraints in cost and logistics of testing fire suppression in a gas turbine engine, a computer modelled fire zone of a hypothetical high-bypass turbofan engine was used to simulate and evaluate the fire suppression performance of three Halon-free agents - HFC-125, HFC-227ea and FIC-13I1. Halon 1301 was also simulated to provide baseline comparison to the alternative agents. The capacity to inert was based on the distribution of agent concentrations subjected to a heptane-based fuel fire. Simulations were conducted at ISASLS and 40,000 feet to represent the engine’s operating environment. Overall, it was found that HFC-125 and HFC-227ea satisfactorily suppressed fire at both ambient scenarios. It was found that agent density and suppression concentration significantly influenced the agent’s ability to mix with ambient air and flood the fire zone. Density of the agent combined with higher inertion concentrations also influenced formation of localised recirculation zones which influenced mixture distribution in the fire zone. The simulations enabled identification of individual changes to agent flow characteristics at different operating conditions and demonstrated the performance criteria of Halon 1301 along with the proposed alternative agents for successful fire suppression. Through this study, it was found that all the agents except FIC-13I1 passed the minimum suppression criteria making HFC-125 and HFC-227ea suitable agents for replacement of Halon 1301. The failure of FIC-13I1 was attributed to the complex design in fire zone and could be overcome by considering a higher factor of safety for this design and injecting higher mass flow rate of the agent into the fire zone. The outcome of this study proposes further work to be carried out through experimental validation of the CFD simulations which will be key to progress the technology to higher TRL and meet aviation certification requirements. Further work may also explore blended agent configurations to tailor the agent characteristics to meet suppression requirements for maintaining safety and reliability of the system.
Disability or disabilities: construction of a specific model of stereotypes
Authors: BURZOTTA Morgane , BERTOLINO Marilena 
Published: March 2023

Abstract
INTRODUCTION- Disability is associated with stereotypes that are detrimental in a work context and may explained disabled difficulties to find and keep a job.
OBJECTIVE- This paper’s aim is to posit and test a model of judgment about disabled people that enhanced classical two-dimensional models (Abele & Wojciszke, 2007; Fiske, Cuddy, Glick, & Xu, 2002)investigating specific stereotypes about disability.
METHODS- Workers (N= 397) had to evaluate a disabled person presented in a hypothetical vignette on 21 stereotypes generally associated with disability. The disability disclosed in the vignette variates between experimental conditions (i.e. depression, HIV, obesity, hearing problems, chronic low back pain, and dyslexia).
RESULTS- An exploratory factor analysis based on the 21 stereotypes revealed a three-dimensional model (i.e. warmth, competence, and contextual performance). When exploring differences between disabilities, depression was systematically perceived more negatively than the other disabilities tested.
CONCLUSIONS- In addition to competence and warmth dimensions, stereotypes about disabled people articulates on a third dimension: contextual performance. This specific preoccupation about disabled workers is important to consider when trying to understand recruiters’ reluctance when hiring a disabled person. Moreover, this study showed that depression is particularly discriminate even when compared to other stereotyped disabilities.
Identification and Validation of Cuproptosis-Related Predictive Risk Signatures based on renal clear cell carcinoma
Authors: Ma Zhihui , Liang Haining , Cui Rongjun , Ji Jinli , Liu Hongfeng , Liu Xiaoxue , Shen Ping , Wang Huan , Wang Xingyun , Song Zheyao , Jiang Ying 
Published: March 2023

Abstract
Background: Renal clear cell carcinoma is the main type of kidney cancer and its prognosis is poor. The role of cuproptosis as an emerging tumor treatment modality in renal clear cell carcinoma is still unclear. Therefore, it is urgent to discover new prognostic markers and the role of Cuproptosis in renal cancer.
Method: The source of cuproptosis-related genes was collected from the reported study from PubMed. RNA expression data and the clinical information of the corresponding patient were obtained from The Cancer Genome Atlas (TCGA) database. We randomly split the whole case into training and testing cohorts. We used three different regression analyses to confirm that lncRNAs with prognostic relevance of KIRC in the training cohort. The test cohort and the whole cohort were also included in the regression analysis to prove the accuracy of the model. eventually, a nomogram on account of clinical characteristics as well as risk scores was constructed to predict survival KIRC.
Result: 119 lncRNAs linked to overall survival were gained by univariate cox regression analysis. Furthermore, to further screen for prognosis-related lncRNAs and to optimize the signature, 119 genes were included in LASSO regression as well as multifactorial Cox regression analysis. A new prognostic predictive risk profile containing four lncRNA was produced. Kaplan-Meier (KM) curve showed that patients in the high-risk group showed poor survival in all three components. The area under the curves (AUCs) for 1 year calculated from the roc curve for the three components is 0.754, 0.698, and 0.743. 0.721 and 0. 753. Moreover, the nomogram allows the calculation of 1-, 3-, and 5-year survival rates for patients with renal clear cell carcinoma.
Conclusion: A new prognostic signature with four CRLs (MYG1-AS1, MELTF-AS1, AL161782.1, AC112220.2) have significant prognostic value for KIRC was conducted. It may provide a new therapeutic treatment for KIRC patients in the clinical.
Effect of m1A regulators on prognosis of colorectal cancer
Authors: Jin Yuqing , Liu Pu , Liu Jiayi , Wang Yu , Ren Weiyan , Tang Xuejiao , Shi Xinrui , Pan Dongchen , Tian Guo , Yang Lei 
Published: March 2023

Abstract
Background
Colorectal cancer (CRC) is one of the most serious public health problems. N1-methyladenosine modification appears to play a significant role in colorectal cancer development. Herein, we attempted to develop a prognostic prediction model to predict colorectal cancer prognosis using multiple m1A regulators and clinical characteristics.
Methods
The TCGA database was used to evaluate the expression of the m1A gene in CRC, and clustering analysis was carried out. The prognostic model of CRC was created using the Limma software, K-M survival analysis, and multivariate Cox regression, and it was then verified using the GEO database.
Results
We comprehensively evaluated m1A modification patterns and identified m1A subtypes used clustering analysis in CRC. Limma package was used to identify 17 differentially expressed m1A regulators in CRC patients, including 14 up-regulated regulators and 3 down-regulated regulators. K-M survival analysis identified three m1A regulators (TRMT61B, HNRNPM, and YTHDC1) associated with overall survival in CRC patients. A gene signature based on these three m1A regulators was developed using multivariate Cox regression which was efficient in predicting long-term prognosis of CRC patients. In addition, multivariate Cox regression analysis demonstrated that risk score (HR: 2.598, 95% CI: 1.226–5.506, P = 0.013) and TNM stage (HR: 1.923, 95% CI: 1.235–2.993, P = 0.004) are two independent prognostic factors. Next, we constructed a nomogram with a concordance index of 0.720 based on gene signature and TNM stage to provide a personalized overall survival prediction in CRC patients. Compared with TNM stage, the nomogram exhibited excellent performance in predicting prognosis. The AUC of 1-, 3- and 5-year OS rates of TNM stage were 0.720, 0.745 and 0.742; whereas the AUC of 1-, 3- and 5-year OS rates of nomogram were 0.721, 0.760 and 0.772 in TCGA database, respectively. Last but not least, the expression of three m1A regulators were verified by q-PCR experiment and the prognostic performance of gene signature and nomogram were validated in a cohort of GEO datasets.
Conclusion
We have constructed and verified a novel prognostic gene signature and a nomogram based on m1A regulators that might effectively promote overall survival prediction in CRC patients.
SPN-AS: A new white-box cryptographic algorithm based on AS iteration structure
Authors: Yang Ya-tao , Zhai Yu-ying , Dong Hui 
Published: March 2023

Abstract
The attacker in white-box model has full access to software implementation of a cryptographic algorithm and full control over its execution environment. In order to solve the issues of high storage cost and inadequate security about most current white-box cryptographic schemes, SPN-AS, a novel white-box block cipher based on AS iterative structure is proposed. This scheme utilizes the AS iterative structure to construct a lookup table with a five-layer ASASA structure, and the maximum distance separable matrix is used as a linear layer to achieve complete diffusion in a small number of rounds. Attackers can be prevented from recovering the key under black-box model. The length of nonlinear layer S and affine layer A in lookup table is 16 bits, which effectively avoids decomposition attack against the ASASA structure and makes the algorithm possess anti-key extraction security under the white-box model, while SPN-AS possesses weak white-box (32KB, 112)-space hardness to satisfy anti-code lifting security. SPN-AS has provable security and better storage cost than existing schemes, with the same anti-key extraction security and anti-code lifting security, only 128KB of memory space is required in SPN-AS, which is only 14% of SPACE-16 algorithm and 33% of Yoroi-16 algorithm.
Investigation on the influence of crosslinking and swelling properties of modified silica-chitosan films for the controlled removal of Alexandrium minutum
Authors: Iqbal Anwar , Ibrahim Nur Hanisah , Mohammad-Noor Normawaty , Razali Roziawati Mohd , Yanto Dede Heri Yuli , Jasni Normawati , Wilson Lee D. 
Published: March 2023

Abstract
Harmful algal blooms (HABs) are natural phenomenon that threatens public health, tourism, fisheries and ecosystems. Silica in its natural form is unable to mitigate HABs effectively and frequently modified with chitosan. In this study, the influence of crosslinking and swelling properties of rice husk ash silica/chitosan film reinforced with (3-glycidyloxypropyl) trimethoxysilane (GPTEOS) and glycerol (Gly) in capturing HABs cell, Alexandrium minutum was thoroughly investigated. The XRD analysis indicated that crosslinking had caused part of the chitosan’s crystalline network to become amorphous. The FTIR analysis showed that the chitosan, silica, glycerol and GPTEOS were crosslinked via a condensation reaction. The crosslinking was higher in the film containing GPTEOS (CHT/SiO2/GPTEOS) due to the condensation reaction between the GPTEOS epoxy group and the amine of chitosan in addition to the condensation of silanol and hydroxyl group of chitosan. As a result, the swelling of CHT/SiO2/GPTEOS was lower compared to Gly-containing film (CHT/SiO2/Gly). The RE value was 26.57 ± 10.81% using CHT/SiO2/Gly and 50.06 ± 11.90% using CHT/SiO2/GPTEOS. Based on the swelling and the RE trends, it is concluded that the initially trapped algae could have been released back into the environment when the films swelled. This study shows that crosslinking is important trapping the algae. The SEM and digital microscopic images of the used films revealed the presence of algae cells on the surface of the films. The films could be easily separated from the algae culture without sedimentation. The films also showed good biodegradability as all the films were fully degraded within 30 days of burial.
Radiation Dose from Cassava Samples from a Coal Mining Area of Enugu, Enugu State, Nigeria
Authors: Amakom Chijioke M. , Orji Chikwendu E. , Okeoma Kelechukwu B. 
Published: March 2023

Abstract
Cassava is one of the most staple food for the Nigerian population and is consumed in large quantity daily. Food intake is one of the routes of radiological contamination to man. Cassava samples from an old coal mining area of Enugu, Enugu State, Nigeria were analyzed using gamma ray spectroscopic method. The mean activity concentrations for the radionuclides 40K, 226Ra and 232Th respectively ranged from 193.68-300.92 Bq/kg, 23.03-37.24 Bq/kg and 135.33-158.43 for camp 1, camp 2 and Pottery areas respectively. The total mean annual effective dose due to the three observed radionuclides was 2.03 mSv/yr, which was higher than the recommended value of 1 mSv/yr. The cassava samples from the area under study showed high radiotoxicity levels.
Compound glycyrrhizin tablets have induced Chronic cardiotoxicity in Sprague-Dawley rats by activating oxidative stress through the Keap1/Nrf2/HO-1 signaling pathway
Authors: Jiang Zhangyu , Ye Ran , Zhang Song , Cai Weibin , Zhang Miao , Yang Dongying , Cai Qiang , Zhang Rong , yang Lei , Xu Qin 
Published: March 2023

Abstract
Introduction: The purpose of this study is to look into the mechanism of chronic cardiotoxicity induced by a long-term use of compound glycyrrhizin tablets (CGT).
Materials and Methods: CGT was orally administered to SD rats. Then, the relative heart weight was measured, and the pathological changes of heart tissue were observed. Physiological indices were determined, including alanine aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), brain natriuretic peptide (BNP), superoxide dismutase (SOD), and malondialdehyde (MDA). The levels of Na+-K+-ATPase and Ca2+-Mg2+-ATPasewere detected. The expressions of M-CK, BNP, Keap1, Nrf2, and HO-1 were assessed.
Results: After several days of CGT treatment, the rats showed heavier relative heart weight and were found to have pathological changes in heart tissues. Moreover, the serum levels of LDH, AST, CK, CK-MB, and BNP were increased in the dose groups. The expression of M-CK was elevated in the middle-dose and high-dose groups, while the level of BNP showed an upward trend. The level of SOD was decreased, and the content of MDA was increased. The expressions of cytoplasma-Keap1 were increased in the middle-dose and high-dose groups, and the expression of nucleus-Nrf2 was reduced in all CGT groups, and the expression of HO-1 was decreased in the high-dose group.
Conclusions: According to these results, we suggest that long-term and high-dose CGT administration is up-regulating Keap1, down-regulating nuclear-Nrf2 and HO-1, resulting in elevating the level of ROS and inducing cardiotoxicity in SD rats by activating the oxidative stress pathway.