bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mood symptoms and chronic fatigue syndrome due to relapsing remitting multiple sclerosis are associated with immune activation and aberrations in the erythron.
Authors: Almulla Abbas F. , Jaleel Al-Karrar Kais Abdul , Algon Ali Abbas Abo , Tunvirachaisakul Chavit , Hassoun Hayder K. , Al-Hakeim Hussein K. , Maes Michael 
Published: February 2023

Abstract
Multiple sclerosis (MS) is a chronic autoimmune and neuroinflammatory disease of the central nervous system characterized by peripheral activation of immune-inflammatory pathways which culminate in neurotoxicity causing demyelination of central neurons. Nonetheless, the pathophysiology of relapsing-remitting MS (RRMS)-related chronic fatigue, depression, anxiety, cognitive impairments, and autonomic disturbances is not well understood. The current study aims to delineate whether the remitted phase of RRMS is accompanied by activated immune-inflammatory pathways and if the latter, coupled with erythron variables, explain the chronic fatigue and mood symptoms due to RRMS. We recruited 63 MS patients, 55 in the remitted phase of RRMS and 8 with secondary progressive MS, and 30 healthy controls and assessed erythron variables and used a bio-plex assay to measure 27 serum cytokines. The results indicate a significant part of the MS patients (46%) displayed activation of the immune-inflammatory response (IRS) and compensatory immune response (CIRS) systems, T helper (Th)1 and Th-17 cytokine profiles. Remitted RRMS patients showed increased chronic fatigue, depression, anxiety, physiosomatic, autonomic, and insomnia scores, which could partly be explained by M1 macrophage, Th1, Th-17, growth factor, and CIRS activation, as well as aberrations in the erythron including lowered hematocrit and hemoglobin levels. In conclusion, around 50% of remitted RRMS patients show activation of immune-inflammatory pathways in association with mood and chronic-fatigue-like symptoms. IRS and CIRS activation as well as the aberrations in the erythron are new drug targets to treat chronic fatigue and affective symptoms due to MS.
Cancer Survivors with Sub-Optimal Patient-Centered Communication Prior to and During the Early COVID Pandemic
Authors: Kim Jiyeong , Fairman Nathan P. , Dove Melanie S. , Hoch Jeffrey S. , Keegan Theresa H. 
Published: February 2023

Abstract
Purpose

Patient-Centered Communication (PCC) is an essential element of patient-centered cancer care. However, our knowledge of recent PCC performance among cancer survivors is limited. Therefore, this study aimed to assess the prevalence of optimal PCC and characterize the sociodemographic and clinical factors associated with optimal PCC in recent years, including during the initial SARS/COVID-19 (COVID) epidemic.

Methods

This study used nationally representative cross-survey data (Health Information National Trends Survey, 2017 to 2020) among cancer survivors (n = 2,579). We calculated the prevalence of optimal PCC of each domain (%) and the overall PCC prevalence (mean score) by time (pre-COVID, 2017-19 vs. COVID, 2020). Multivariable-adjusted weighted logistic regression models were developed to estimate the odds ratio (OR) and 95% confidence intervals (95% CI) of optimal PCC for each domain, as well as the overall outcome.

Results

The prevalence of optimal PCC decreased in most domains during COVID compared to pre-COVID up to 7.3% (managing uncertainty). Cancer survivors who reported psychological distress (ORs = 0.45–0.67 little interest or nervousness), did not have a usual source of care (ORs = 1.77–2.34), or were male (ORs = 1.40–1.78) were less likely to have optimal PCC in most domains as well as the overall PCC assessments.

Conclusions

We identified subgroups of vulnerable cancer survivors with sub-optimal PCC during COVID.
Association of hemoglobin-to-red blood cell distribution width ratio and depression: a cross sectional study
Authors: Xi Lijuan , Zhou Jiajie , Xu Peirong , Zhang Yan , Zhu pinting , Tu Jiayuan , Sun Qiannan , Fang Fang 
Published: February 2023

Abstract
Objectives
We aimed to explore the association between hemoglobin-to-red blood cell distribution width ratio (HRR) and the depression.
Methods
Depression, general characteristics, life style, medical history, drug use, blood indicators were extracted from the National Health and Nutrition Examination Survey 2005–2018 to assess the relationship between HRR and depression. Two sample kolmogorove-smirnov test, chi-square test, spearman correlation, multiple linear regression and the receiver operating characteristic (ROC) curve were analysed.
Results
31784 participants were included and the incidence rate of depression was 9.05%. HRR was significant lower in low depression group and positive associated with depression(P < 0.05). Multiple linear regression showed that HRR was associated with depression after adjusted for general characteristics, life style, medical history, drug use and blood indicators (P < 0.05). The cutoff value of HRR for depression is 1.090 and the Youden index, sensitivity, and specificity of HRR to depression is higher than hemoglobin (Hb) and red blood cell distribution width ratio (RDW).
Conclusions
HRR, powerful than Hb or RDW, is an independent risk factor for depression. Clinicians should focus on the HRR to improve depression.
Performance Analysis of various Pre-Equalization techniques for Visible Light Communication
Authors: R Priyadharshini , A Sivanantha Raja 
Published: February 2023

Abstract
Visible Light Communication (VLC) is a well known emerging technology for indoor communication that has drawn more attention in recent years. The name itself indicates that the medium to transfer data in VLC technology is the light that travels in free space. During VLC Inter-Symbol Interference (ISI) in free space channel occurs due to reflectivity of surfaces like walls and ceiling. In order to overcome this problem an inverse filter called equalizer is placed. Equalizers are feasible solution to improve the transmission performance. In this paper, the performance of VLC system is analyzed with various pre-equalization techniques using Optisystem V.16 simulation tool for a practically measured parameters since the spectrum of LED required equalization. This simulation is carried out by placing various equalizers such as Spaced Feed Forward Equalizer, Fractionally Spaced Feed Forward Equalizer, Decision Feedback Equalizer, Combination of both Feed Forward and Decision Feedback Equalizer and Adaptive Equalizer at transmitter side for different bitrates and different link ranges. With adaptive pre-equalization, this VLC system can support 2 Gbps data rate up to 5 m range with a Q factor of 8.52. Under the influence of external white light (noise) of power − 80dBm and below, the proposed system works well. Above − 80dBm, the modulated light is disturbed, so that the data obtained is slightly degraded.
Bioinformatic analysis identifying Endoplasmic Reticulum Stress-Related genes as a new diagnostic and prognostic indicator in clear cell Renal Cell Carcinoma
Authors: Yu Haitao , Bai Xuesong , Yin Hubin , Li Xinyuan , Zhou Xiang , He Weiyang , Kuang Youlin , Gou Xin , Li Jie 
Published: February 2023

Abstract
Clear cell renal cell carcinoma (ccRCC) is one of the most common cancer types worldwide, and its incidence is increasing year by year. Endoplasmic reticulum stress (ERS) caused by protein misfolding has broad and profound effects on the progression and metastasis of various cancers. Accumulating evidence suggests that ERS-related genes are closely related to the occurrence and progression of ccRCC. This study aimed to identify ERS-related signature genes for evaluating the prognosis of ccRCC patients. Transcriptomic expression profiles of patients with ccRCC from public databases Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) and survival data and clinical phenotype data of patients in the TCGA database were used. Then the GeneCards database was used to identify the differentially expressed genes related to ERS. We obtained 11 signature genes, and then used the Lasso regression method to establish a diagnostic model, univariate and multivariate Cox analysis was used to analyze the correlation between the expression levels of the signature genes and the clinical characteristics, and finally 5 signature genes were associated with poor prognosis (TNFSF13B, APOL1, COL5A3, CDH5）. In summary, this study suggests that these genes may have potential as prognostic biomarkers in ccRCC and may provide new evidence to support targeted therapy in ccRCC.
Reaction of common bean genotypes to Sclerotium root rot (Sclerotium rolfsii Sacc.) under screen house conditions in Uganda
Authors: Tilahun Nigat , Edema Richard , Mukankusi Clare , Tolosa Kidist , Abebe Desta , Gibson Paul 
Published: February 2023

Abstract
Sclerotium root rot caused by Sclerotium rolfsii Sacc. is one of the major soil-borne diseases of common bean in Uganda and many other countries. An incidence and severity of 100% and 84% respectively, has been reported in the common bean production environments in Uganda. The use of resistant cultivars is reported as the most efficient management strategy against root rot diseases. A few breeding lines showing good levels of resistance have been identified, however currently all released varieties in Uganda lack resistance to the disease. The objectives of this study were to enhance breeding for Sclerotium root rot resistance through validating the resistance in the identified breeding lines and identify new sources. A total of 72 genotypes with two checks (K132 and KWP 9) were evaluated under screen house at NaCRRI (2017A & 2017B) with 9 x10 alpha-lattice design arrangement by three replications. Each genotype was planted in a wooden tray containing pre-sterilized soil inoculated with matured LWE 336-1 Sclerotium isolate. Germination and disease severity were assessed 14 and 28 days after planting (DAP), respectively. The result showed significant (P < 0.001) difference among genotypes both for germination percentage and disease severity, suggesting that substantial genetic variation among the evaluated genotypes. The breeding lines: KWP 12, KWP 17, KWP 9, and ALB 171 were confirmed to be resistance and RRA 41 was identified as a new source of resistance. These genotypes were therefore recommended for further utilization in common bean breeding program to improve Sclerotium root rot resistance in Ugandan susceptible varieties.
On the Propagation of Sound Waves in a Vacuum
Authors: Lauter Robert 
Published: February 2023

Abstract
Until the discovery of the accelerated expansion of the universe in the late 1990s, the great majority of physicists were convinced that there was not any kind of sound in any kind of vacuum. The latter specification is necessary because nowadays we discuss whether there is the possibility that sound actually does propagate in space which is free of ordinary matter but filled with “dark energy”. The term “vacuum” for such kind of empty space is avoided by most authors as it remains reserved for models of empty space in which the cosmological constant acts as a source of vacuum energy.Before this discussion started, evidence for vanishing propagation of sound in a vacuum apparently aroused from an experiment designed by Otto von Guericke in the 17th century although his intention was merely to show that a vacuum actually does exist. This article will show that the interpretation of this experiment as a proof for vanishing sound-propagation in a vacuum has been a fundamental philosophical mistake and furthermore that any theoretical investigations of sound in space which is free of any kind of matter may require a quantum-theoretical approach.
Continuum mechanics from an observer's viewpoint
Authors: Belevich Michael 
Published: February 2023

Abstract
A variant of the relativistic continuum mechanics with the measureis presented. The theory satisfies the following principles: the causalityprinciple, the general covariance principle, the correspondence principle,and Einstein's principle of relativity. The group analysis of theresulting equations shows that they admit the Poincarй group of transformations,and appear to be Lorentz-invariant. The measure conservation law isthe basis of the discussed theory, and the observer is its necessarycomponent.
The theory does not imply any speed limitation of an object. Arbitraryvalues of velocity are admissible. However, since the velocity ofan object is being measured using the signal propagating with somefinite speed, this latter speed in fact acts as a limit for the measuredvelocities of objects. This is due to the fact that objects movingfaster than the speed of the signal (information propagation) eitherbecome unobservable, or their measured velocity turns out to be seemingand does not exceed the signal speed.
Various options for synchronization and construction of spaces ofsimultaneous events are considered. Another distinctive feature ofthe constructed environment model is the smaller number of postulatedstatements. For example, the total energy conservation law holds.However, it is not postulated, as in the classical fluid model., butfollows from the mass conservation law and, therefore, is a theorem.Also, local thermodynamic equilibrium does not require postulation. Finally, the second law of thermodynamics does not hold in the caseswhen the speed of the signal providing the observer with informationabout the phenomenon under study is less than the speed of the object. Such behavior is corroborated using the corresponding numerical models,in particular, based on the explicit difference methods. A similarphenomenon is known as the absence of stability of the numerical algorithm.
Two levels of description within the considered model are demonstrated. This reflects the presence of two main physical interpretations ofthe developed theory - hydromechanical and electromagnetic.Both interpretations are discussed and corresponding systems of equationsare presented.
PACS numbers: 40., 47., 47.10.-g, 47.10.A-
Infinite-volume states with irreducible localization sets for gradient models on trees
Authors: Abbondandolo Alberto , Henning Florian , Kuelske Christof , Majer Pietro 
Published: February 2023

Abstract

We consider general classes of gradient models on regular trees with values in a countable Abelian group S such as Z or Zq, in regimes of strong coupling (or low temperature). This includes unbounded spin models like the p-SOS model and finite-alphabet clock models. We prove the existence of families of distinct homogeneous tree-indexed Markov chain Gibbs states μA whose single-site marginals concentrate on a given finite subset A ⊂ S of spin values, under a strong coupling condition for the interaction, depending only on the cardinality |A| of A. The existence of such states is a new and robust phenomenon which is of particular relevance for infinite spin models. These states are not convex combinations of each other, and in particular the states with |A| ≥ 2 can not be decomposed into homogeneous Markov-chain Gibbs states with a single-valued concentration center. As a further application of the method we obtain moreover the existence of new types of Z-valued gradient Gibbs states, whose single-site marginals do not localize, but whose correlation structure depends on the finite set A.
MSC2020 subject classifications: 82B26 (primary); 60K35 (secondary)
Impact of non-proteinogenic amino acid norvaline and proteinogenic valine misincorporation on a secondary structure of a model peptide
Authors: Škibola Zara , Sovulj Ita Gruić , Maršavelski Aleksandra 
Published: February 2023

Abstract
Norvaline is a straight-chain, hydrophobic, non-proteinogenic
amino acid, isomeric with valine. Both amino acids can be
misincorporated into proteins at isoleucine positions by
isoleucyl-tRNA synthetase when the mechanisms of translation
fidelity are impaired. Our previous study showed that the
proteome-wide substitution of isoleucine with norvaline resulted in
higher toxicity in comparison to the proteome-wide substitution of
isoleucine with valine. Although mistranslated proteins/peptides
are considered to have non-native structures responsible for their
toxicity, the observed difference in protein stability between
norvaline and valine misincorporation has not yet been fully
understood. To examine the observed effect, we chose the model
peptide with three isoleucines in the native structure, introduced
selected amino acids at isoleucine positions and applied
molecular-dynamics simulations at different temperatures. The
obtained results showed that norvaline has the highest destructive
effect on the β-sheet structure and suggested that the higher
toxicity of norvaline over valine is predominantly due to the
misincorporation within the β-sheet secondary elements.
Mechanical and thermal properties of a nanocomposite made of a polymer matrix reinforced by a binary nanoparticle TiO2 - SiO2 produced by sol-gel method
Authors: zahrouni Aymen , Benammar Ikram , Harzallah Omar , Bistac Sophie , Rached Salhi 
Published: February 2023

Abstract
This study investigated the effect of adding 5% wt of SiO2-TiO2 nanoparticles to polyester-fiberglass on the structural, mechanical and thermal behaviours of the nanocomposite. For this purpose, scanning electron microscopy (SEM) and a Fourier transform infrared spectroscopy (FTIR) were used to examine the surface modification and morphology of the nanocomposites. After the heat treatment of this materialat different compositions, it was observed that its crystalline state was changed and a rutile structure appeared in the treated nanofillers. However, the presence of SiO2 seemed to prevent the complete conversion to this structure. Hence, this change in the microstate affected the mechanical and behavior of the nanocomposite. Indeed, theaddition of 5% wt divided in 75%SiO2-25%TiO2 to the nanocomposite increasedits Young’s modulus by 15.15% and its microhardness by 14%. Furthermore, in terms of thermal behaviour, the addition of 5% wt divided in 75%SiO2-25%TiO2 yieldeda thermal resistance of TG = 49.66 °C.
These results would imply the production of nanocomposite with a specific high resistance, a high modulus and a good fatigue resistance which would present a potential replacement for other materials in various industrial applications.
Comparative Performance of Prostephanus Truncatus(Horn) (Coleoptera:bostrichidae) on Different Processed Varieties of Cassava (Manihot Esculenta(Crantz)) Chips Treated With Zingiber Officinale and Deltamethin
Authors: Ejiofor MaryGeraldine Ebele , Okonkwo Nnaemeka Joe 
Published: February 2023

Abstract
In Africa, Prostephanus truncatus is a destructive pest of economic importance which has deteriorative effects on dry cassava chips in storage. The present study investigates the effects of Zingiber officinale on P.truncatus on dried cassava chips processed in two methods. Deltamethrin was used as the reference insecticide. The plant extract was used at different concentrations (500ul/ml, 250ul/ml, 125ul/ml, 62.5ul/ml, 0ul/ml(control) and 0.05ul/ml(reference)). The cassava varieties used are TME 419 and TMS 98/0581. the cassava varieties were cut into cubes and subjected to two processing methods, parboiling and unparboiling (plain). Percentage emergence was assesed as thus, 100g of cassava chips were put in a plastic plate. 10 unsexed adult of P.truncatus were introduced into each plate and left for 14days to oviposit, after which the insects were removed , the chips were thereafter treated with Z.officinale at (500ul/ml, 250ul/ml, 125ul/ml, 62.5ul/ml, 0ul/ml(control) and 0.05ul/l(Deltamethrin). The plates were covered with muslin cloth held with a rubber band and left to stand for 25 days. Afterwhich the percentage emergence was assessed, by counting. All the data generated were subjected to one-way analysis of variance (ANOVA) in Genstat package 9.2 (9th edition). Difference between mean values were separated using least significant difference (LSD) at P<0.05 (Finney 1971). The result of the experiment showed that Z.officinale conferred greater protection to the chips at higher concentrations of 250ul/ml and 500ul/ml , its effects were similar to the reference insecticide. Processing methods recorded a great significance(P <0.05) .
Pulmonary rehabilitation can alter the respiratory microbiome in patients with COPD
Authors: Ma Haiman , Wu Shuo , Zhang Yan , Xu Xi , Zhang Xiaoxiao , Zhao Feng , Ti Xinyu , Qu Shuoyao 
Published: February 2023

Abstract
Background
As one of the main causes ofchronic obstructive pulmonary disease (COPD), respiratory microbiome is of great significance to the disease progression. Meanwhile, pulmonary rehabilitation (PR), as an effective nonpharmacologicintervention for COPD, evaluation of the efficacy is limited to the improvement of symptoms and lung function, which is one-sided to a certain extent. Therefore, an individualized 2-week intensive PR programme was established in the present study for patients with COPD to investigate whether this short course of PR can have impact on respiratory microbiome in patients.
Methods
The patients with stable COPD who participated in this study underwent short-term, high-intensity and center-based PR programme, which included two major components: respiratory muscle training and vibration expectoration. Sputum samples were collected before and after the PR to detect alterations of respiratory microbiome by metagenomic sequencing. The main purpose was to observe changes of composition, function and resistance genes in respiratory microbiomebefore and after PR, and explore the relationship of respiratory microbiome with lung function and symptoms.
Results
After the 2-week intensive PR, the abundance of Firmicutes, Actinobacteria and Bacteroidetesdecreased, while that of Proteobacteria increased at the phylum level; the abundance of Streptococcus and Prevotella decreased, while that of Neisseria increased at the genus level. Concomitantly, it was found that Firmicutes, Actinobacteria, Streptococcus and Prevotella were negatively correlated with lung function and positively correlated with CAT score, while Neisseria was positively correlated with lung function and negatively correlated with CAT score. Based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, the functional abundance of most respiratory microbiome decreased after 2-week PR. Simultaneously, the species function abundance was negatively correlated with the lung function of COPD. In addition, the resistance gene fluctuated with the attribution of the species, and the macrolide resistance genes of COPD were significantly reduced after 2-week PR.
Conclusions
The short course of intensive PR can alter the composition, function and antibiotic resistance genes of respiratory microbiome in patients with COPD, which plays a role by promoting the self-regulation ability of patients. This study provides a novel, gentle and non-pharmacologic intervention for the regulation of microbiome in the future.