bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large language model (ChatGPT) as a support tool for breast tumor board
Authors: Sorin Vera , Klang Eyal , Sklair-Levy Miri , Cohen Israel , Zippel Douglas B. , Balint Lahat Nora , Konen Eli , Barash Yiftach 
Published: May 2023

AbstractLarge language models (LLM) such as ChatGPT have gained public and scientific attention. The aim of this study is to evaluate ChatGPT as a support tool for breast tumor board decisions making. We inserted into ChatGPT-3.5 clinical information of ten consecutive patients presented in a breast tumor board in our institution. We asked the chatbot to recommend management. The results generated by ChatGPT were compared to the final recommendations of the tumor board. They were also graded independently by two senior radiologists. Grading scores were between 1–5 (1 = completely disagree, 5 = completely agree), and in three different categories: summarization, recommendation, and explanation. The mean age was 49.4, 8/10 (80%) of patients had invasive ductal carcinoma, one patient (1/10, 10%) had a ductal carcinoma in-situ and one patient (1/10, 10%) had a phyllodes tumor with atypia. In seven out of ten cases (70%), ChatGPT’s recommendations were similar to the tumor board’s decisions. Mean scores while grading the chatbot’s summarization, recommendation and explanation by the first reviewer were 3.7, 4.3, and 4.6 respectively. Mean values for the second reviewer were 4.3, 4.0, and 4.3, respectively. In this proof-of-concept study, we present initial results on the use of an LLM as a decision support tool in a breast tumor board. Given the significant advancements, it is warranted for clinicians to be familiar with the potential benefits and harms of the technology.
Multi-scale investigation of short-range order and dislocation glide in MoNbTi and TaNbTi multi-principal element alloys
Authors: Zheng Hui , Fey Lauren T. W. , Li Xiang-Guo , Hu Yong-Jie , Qi Liang , Chen Chi , Xu Shuozhi , Beyerlein Irene J. , Ong Shyue Ping 
Published: May 2023

AbstractRefractory multi-principal element alloys (RMPEAs) are promising materials for high-temperature structural applications. Here, we investigate the role of short-range ordering (SRO) on dislocation glide in the MoNbTi and TaNbTi RMPEAs using a multi-scale modeling approach. Monte carlo/molecular dynamics simulations with a moment tensor potential show that MoNbTi exhibits a much greater degree of SRO than TaNbTi and the local composition has a direct effect on the unstable stacking fault energies (USFEs). From mesoscale phase-field dislocation dynamics simulations, we find that increasing SRO leads to higher mean USFEs and stress required for dislocation glide. The gliding dislocations experience significant hardening due to pinning and depinning caused by random compositional fluctuations, with higher SRO decreasing the degree of USFE dispersion and hence, amount of hardening. Finally, we show how the morphology of an expanding dislocation loop is affected by the applied stress.
Disruption of locus coeruleus-related functional networks in Parkinson’s disease
Authors: Sun Junyan , Ma Jinghong , Gao Linlin , Wang Junling , Zhang Dongling , Chen Lili , Fang Jiliang , Feng Tao , Wu Tao 
Published: May 2023

AbstractLocus coeruleus (LC) is severely affected in Parkinson’s Disease (PD). However, alterations in LC-related resting-state networks (RSNs) in PD remain unclear. We used resting-state functional MRI to investigate the alterations in functional connectivity (FC) of LC-related RSNs and the associations between RSNs changes and clinical features in idiopathic rapid eye movement sleep behavior disorder (iRBD) and PD patients with (PDRBD+) and without RBD (PDRBD−). There was a similarly disrupted FC pattern of LC-related RSNs in iRBD and PDRBD+ patients, whereas LC-related RSNs were less damaged in PDRBD− patients than that in patients with iRBD and PDRBD+. The FC of LC-related RSNs correlated with cognition and duration in iRBD, depression in PDRBD−, and cognition and severity of RBD in patients with PDRBD+. Our findings demonstrate that LC-related RSNs are significantly disrupted in the prodromal stage of α-synucleinopathies and proposed body-first PD (PDRBD+), but are less affected in brain-first PD (PDRBD−).
The international role of education in sustainable lifestyles and economic development
Authors: Piao Xiangdan , Managi Shunsuke 
Published: May 2023

AbstractImproved economic growth and environmental protection are necessary to achieve the United Nations’ Sustainable Development Goals. This study examines the relationship between people’s education levels and sustainable lifestyles in protecting the environment and economic growth, as expressed by the increase in household equivalent income. We conducted an original cross-sectional survey, which yielded 100,956 valid observations in 37 countries. The factors included educational level, sustainable lifestyle with natural resource consumption, and household equivalent income for economic development. We used logit and ordered logit model and applied an ordinary linear regression model after confirming the association between education and income. Our analyses found that higher educational levels were associated with an increase in specific environmentally friendly behaviors and sustainable energy consumption. Individuals in the higher educational level group tended to consume recycled goods, purchase energy-saving household products, conserve electricity, and separate their waste. Additionally, higher levels of education were positively associated with equivalent household income in all 37 countries, indicating better economic development. Thus, our study underscores the importance of improving education at the broad population level to promote economic development and establish cooperative human behaviors necessary to sustain the environment.
Microfibril-associated protein 5 and the regulation of skin scar formation
Authors: Han Chen , Leonardo Trevor R. , Romana-Souza Bruna , Shi Junhe , Keiser Shalyn , Yuan Heidi , Altakriti Mohamad , Ranzer Matthew J. , Ferri-Borgogno Sammy , Mok Samuel C. , Koh Timothy J. , Hong Seok Jong , Chen Lin , DiPietro Luisa A. 
Published: May 2023

AbstractMany factors regulate scar formation, which yields a modified extracellular matrix (ECM). Among ECM components, microfibril-associated proteins have been minimally explored in the context of skin wound repair. Microfibril-associated protein 5 (MFAP5), a small 25 kD serine and threonine rich microfibril-associated protein, influences microfibril function and modulates major extracellular signaling pathways. Though known to be associated with fibrosis and angiogenesis in certain pathologies, MFAP5’s role in wound healing is unknown. Using a murine model of skin wound repair, we found that MFAP5 is significantly expressed during the proliferative and remodeling phases of healing. Analysis of existing single-cell RNA-sequencing data from mouse skin wounds identified two fibroblast subpopulations as the main expressors of MFAP5 during wound healing. Furthermore, neutralization of MFAP5 in healing mouse wounds decreased collagen deposition and refined angiogenesis without altering wound closure. In vitro, recombinant MFAP5 significantly enhanced dermal fibroblast migration, collagen contractility, and expression of pro-fibrotic genes. Additionally, TGF-ß1 increased MFAP5 expression and production in dermal fibroblasts. Our findings suggest that MFAP5 regulates fibroblast function and influences scar formation in healing wounds. Our work demonstrates a previously undescribed role for MFAP5 and suggests that microfibril-associated proteins may be significant modulators of wound healing outcomes and scarring.
Community-based diabetes prevention randomized controlled trial in refugees with depression: effects on metabolic outcomes and depression
Authors: Wagner Julie A. , Bermúdez-Millán Angela , Buckley Thomas E. , Buxton Orfeu M. , Feinn Richard S. , Kong Sengly , Kuoch Theanvy , Scully Mary F. 
Published: May 2023

AbstractDepression and antidepressant medications increase risk for type 2 diabetes. Cambodian-Americans have exceedingly high rates of both depression and diabetes. This paper reports outcomes of a diabetes prevention trial for Cambodian-Americans with depression. Primary outcomes were HbA1c, insulin resistance and depressive symptoms. Participants were aged 35–75, Khmer speaking, at risk for diabetes, and met study criteria for likely depression by either (a) antidepressant medication and/or (b) prolonged elevated depressive symptoms. Participants were randomized to one of three community health worker (CHW) interventions: (1) lifestyle intervention called Eat, Walk, Sleep (EWS), (2) EWS plus medication therapy management sessions with a pharmacist/CHW team to resolve drug therapy problems (EWS + MTM), or, (3) social services (SS; control). Assessments were at baseline, post-treatment (12 months), and follow-up (15 months). The n = 188 participants were 78% female, average age of 55 years, half had a household income < $20,000, and modal educational attainment was 7.0 years. Compared to the other arms, EWS + MTM showed a significant decrease in HbA1c and a trend for reduced inflammation and stress hormones. Depressive symptoms improved for EWS and EWS + MTM relative to SS. There was no change in insulin resistance. Cardiometabolic and mental health can be improved in tandem among immigrant and refugee groups.
Severe SARS-CoV-2 infection as a marker of undiagnosed cancer: a population-based study
Authors: Dugerdil Adeline , Semenzato Laura , Weill Alain , Zureik Mahmoud , Flahault Antoine 
Published: May 2023

AbstractNo study has yet investigated if a severe SARS-CoV-2 infection represents a marker of an undiagnosed cancer. This population-based study, using the SNDS database, identified from 02/15/2020 to 08/31/2021, 41,302 individuals hospitalized in intensive care unit due to SARS-CoV-2 (ICU-gr) and 713,670 control individuals not hospitalized for SARS-CoV-2 (C-gr). Individuals were matched according to year of birth, sex and French department. The cancer incidence was compared in the two groups during the follow-up period (index date-12/31/2021), using Cox proportional hazards models adjusted on matching variables, socioeconomic characteristics and comorbidities. In the ICU-gr, 2.2% (n = 897) was diagnosed with a cancer in the following months, compared to 1.5% (n = 10,944) in the C-gr. The ICU-gr had a 1.31 higher risk of being diagnosed with a cancer following hospital discharge compared to the C-gr (aHR 1.31, 95% CI 1.22–1.41). A global similar trend was found when competing risk of death was taken into account (aHR 1.25, 95% CI 1.16–1.34). A significant higher risk was found concerning renal (aHR 3.16, 95% CI 2.33–4.27), hematological (aHR 2.54, 95% CI 2.07–3.12), colon (aHR 1.72, 95% CI 1.34–2.21), and lung (aHR 1.70, 95% CI 1.39–2.08) cancers. This suggests that a severe SARS-CoV-2 infection may represent a marker of an undiagnosed cancer.
Recent increase in the potential threat of western North Pacific tropical cyclones
Authors: Li Yi , Tang Youmin , Li Xiaojing , Song Xiangzhou , Wang Qiang 
Published: May 2023

AbstractConventionally, the threat of tropical cyclones (TCs) is often described by TC intensity. However, the damage caused by TCs is also strongly related to our forecasting ability, which is usually low for TCs with high intensification rates. Here, we challenge this intensity-only criterion and propose a concept of TC potential threat (PT) for the western North Pacific TCs by jointly clustering the TC lifetime maximum intensity and intensification rate. We show that TCs can be separated via an objective algorithm, and approximately 10% of all TCs pose a great PT and feature high forecast errors. Furthermore, the annual number of TCs with high PT has increased by 22% per decade over the past 41 years, and this trend is attributed to the rise in subsurface ocean temperatures. Our study provides a perspective on the TC threat and reveals its increase due to global warming and internal climate variability.
Co3−xFexO4 inverse opals with tunable catalytic activity for high-performance overall water splitting
Authors: Nguyen Thi Hong Trang , Zarkua Zviadi , Chinnappa Chinnabathini Vana , Hu Wenjian , Sree Sreeprasanth Pulinthanathu , Grandjean Didier , Pant Deepak , Janssens Ewald 
Published: May 2023

We developed an earth-abundant and high-performance mesoporous Co3−xFexO4 inverse opals-based bifunctional catalyst for overall electrochemical water splitting.
[α-AsW9O33]9− bridged hexagonal clusters of Ln(iii) showing field induced SMM behavior: experimental and theoretical insight
Authors: Kapurwan Sandhya , Sahu Pradip Kumar , Raizada Mukul , Kharel Ranjan , Konar Sanjit 
Published: May 2023

A new strategy to synthesize lanthanide complexes using [As2W19O67(H2O)]14− anion for SMM behavior as well as to explore the photoluminescence behavior.
Effects of the Number of Channels and Channel Stimulation Rate on Speech Recognition and Sound Quality Using Precurved Electrode Arrays
Authors: Berg Katelyn A. , Chen Chen , Noble Jack H. , Dawant Benoit M. , Dwyer Robert T. , Labadie Robert F. , Gifford René H. 
Published: May 2023

Purpose:
This study investigated the relationship between the number of active electrodes, channel stimulation rate, and their interaction on speech recognition and sound quality measures while controlling for electrode placement. Cochlear implant (CI) recipients with precurved electrode arrays placed entirely within scala tympani and closer to the modiolus were hypothesized to be able to utilize more channels and possibly higher stimulation rates to achieve better speech recognition performance and sound quality ratings than recipients in previous studies.

Method:
Participants included seven postlingually deafened adult CI recipients with Advanced Bionics Mid-Scala electrode arrays confirmed to be entirely within scala tympani using postoperative computerized tomography. Twelve conditions were tested using four, eight, 12, and 16 electrodes and channel stimulation rates of 600 pulse per second (pps), 1,200 pps, and each participant's maximum allowable rate (1,245–4,800 pps). Measures of speech recognition and sound quality were acutely assessed.

Results:
For the effect of channels, results showed no significant improvements beyond eight channels for all measures. For the effect of channel stimulation rate, results showed no significant improvements with higher rates, suggesting that 600 pps was sufficient for maximum speech recognition performance and sound quality ratings. However, across all conditions, there was a significant relationship between mean electrode-to-modiolus distance and all measures, suggesting that a lower mean electrode-to-modiolus distance was correlated with higher speech recognition scores and sound quality ratings.

Conclusion:
These findings suggest that even well-placed precurved electrode array recipients may not be able to take advantage of more than eight channels or higher channel stimulation rates (> 600 pps), but that closer electrode array placement to the modiolus correlates with better outcomes for these recipients.
Tone Deafness in Music Does Not Preclude Distributional Learning of Nonnative Tonal Languages in Individuals With Congenital Amusia
Authors: Zhu Jiaqiang , Chen Xiaoxiang , Chen Fei , Zhang Caicai , Shao Jing , Wiener Seth 
Published: June 2023

Purpose:
Previous studies have shown that individuals with congenital amusia exhibit deficient pitch processing across music and language domains. This study investigated whether adult Chinese-speaking listeners with amusia were still able to learn Thai lexical tones based on stimulus frequency of statistical distribution via distributional learning, despite their degraded lexical tone perception.

Method:
Following a pretest–training–posttest design, 21 amusics and 23 typical, musically intact listeners were assigned into bimodal and unimodal distribution conditions. Listeners were asked to discriminate minimal pairs of Thai mid-level tone and falling tone superimposed on variable base syllables and uttered by different speakers. The perceptual accuracy for each test session and improvement from pretest to posttest were collected and analyzed between the two groups using generalized mixed-effects models.

Results:
When discriminating Thai lexical tones, amusics were less accurate than typical listeners. Nonetheless, similarly to control listeners, perceptual gains from pretest to posttest were observed in bimodally rather than unimodally trained amusics, as evidenced by both trained and nontrained test words.

Conclusions:
Amusics are able to learn lexical tones in a second or foreign context of speech. This extends previous research by showing that amusics' distributional learning of linguistic pitch remains largely preserved despite their degraded pitch processing. It is thus likely that manifestations of amusia in speech could not result from their abnormal statistical learning mechanism. This study meanwhile provides a heuristic approach for future studies to apply this paradigm into amusics' treatment to mitigate their pitch-processing disorder.
Coordinated active and reactive power management for enhancing PV hosting capacity in distribution networks
Authors: Golnazari Rezvaneh , Hasanzadeh Saeed , Heydarian‐Forushani Ehsan , Kamwa Innocent 
Published: May 2023

AbstractThis paper proposes an operational planning model based on optimal active and reactive power control strategies to enhance solar photovoltaics (PV)’ hosting capacity in distribution networks. Reactive power control is carried out through optimum static VAr compensators (SVCs) placement, while active power control is performed through flexible loads, particularly shiftable and interruptible loads. The first stage of the proposed two‐stage stochastic model assigns decision‐making regarding calculating PV hosting capacity at different nodes, in addition to the allocation and capacity of SVCs. In the second stage, the first stage decisions are assessed to ensure the power flow constraints under various uncertainties such as daily load and stochastic PV generation. The presented model is investigated through numerical analyses on modified IEEE 15‐bus and IEEE 33‐bus distribution systems considering different active‐reactive strategy cases. While most previous works only rely on one type of active or reactive power control strategy, this study investigates the challenges of the respective application of active and reactive power control in various modes of fundamental practices. The obtained results prove the superiority of the proposed hybrid active‐reactive control strategy for enhancing PV hosting capacity compared to respective active or reactive power controls.
Rotation and interaction of the CMEs of September 8 and 10, 2014, tested with EUHFORIA
Authors: Maharana Anwesha , Scolini Camilla , Schmieder Brigitte , Poedts Stefaan 
Published: June 2023

Context. Solar coronal mass ejections (CMEs) can catch up and interact with preceding CMEs and solar wind structures to undergo rotation and deflection during their propagation.
Aim. We aim to show how the interactions of a CME in the corona and heliosphere can play a significant role in altering its geoeffectiveness as predicted at the time of its eruption. To do so, we consider a case study of two successive CMEs launched from the active region NOAA 12158 in early September 2014. The second CME was predicted to be extensively geoeffective based on the remote-sensing observations of the source region. However, in situ measurements at 1 au recorded only a short-lasting, weak negative Bz component followed by a prolonged positive Bz component.
Methods. We used the EUropean Heliosphere FORecasting Information Asset (EUHFORIA) to perform a self-consistent 3D magnetohydrodynamical (MHD) data-driven simulation of the two CMEs in the heliosphere. First, the ambient solar wind is modelled, followed by the time-dependent injection of CME1 with the LFF spheromak and CME2 with the Flux Rope in 3D (FRi3D) model. The initial conditions of the CMEs are determined by combining observational insights near the Sun, which are fine-tuned to match the in situ observations near 1 au, with additional numerical experiments related to each individual CME.
Results. By introducing CME1 before CME2 in the EUHFORIA simulation, we modelled the negative Bz component in the sheath region ahead of CME2 whose formation can be attributed to the interaction between CME1 and CME2. To reproduce the positive Bz component in the magnetic ejecta of CME2, we had to initialise CME2 with an orientation determined at 0.1 au and consistent with the orientation interpreted at 1 au instead of the orientation observed during its eruption.
Conclusions. EUHFORIA simulations suggest the possibility of a significant rotation of CME2 in the low corona in order to explain the in situ observations at 1 au. Coherent magnetic field rotations with enhanced strength (potentially geoeffective) can be formed in the sheath region as a result of interactions between two CMEs in the heliosphere even if the individual CMEs are not geoeffective.
Aerobic Training Increases Hippocampal Volume and Protects Cognitive Function for Type 2 Diabetes Patients with Normal Cognition
Authors: Wang Ying , Wang Liping , Yan Juan , Yuan Xiaodan , Lou Qing Q. 
Published: June 2023

AbstractAim To evaluate the effects of aerobic training on hippocampal volume and cognitive function in patients with type 2 diabetes mellitus (T2DM) with normal cognition.Materials and methods One hundred patients with T2DM aged 60–75 years who met inclusion criteria were randomized into the aerobic training group (n=50) and control group (n=50). The aerobic training group received 1 year of aerobic training, while the control group maintained their lifestyle without additional exercise intervention. The primary outcomes were hippocampal volume measured by MRI and Mini-mental State Examination (MMSE) score or Montreal Cognitive Assessment scale (MoCA) scores.Results Eighty-two participants completed the study (aerobic training group, n=40; control group, n=42). There was no significant difference between the two groups at baseline (P>0.05). After one year of moderate aerobic training, increase in total and right hippocampal volume in the aerobic training group were significantly higher than in the control group (P=0.027, P=0.043, respectively). In the aerobic group, total hippocampal volume significantly increased after the intervention compared with baseline (P=0.034). The between-group difference in the change of MMSE and MoCA scores was statistically significant (P=0.015, P=0.027, respectively). Logistic regression showed strong correlations between aerobic training and increase in total hippocampal volume (OR:1.091, [95%CI 0.969, 1.228], P=0.002), improvement of MMSE scores (OR:1.127, [95%CI 1.005, 1.263], P=0.041) or MoCA scores (OR:2.564, [95%CI 2.098.2.973], P=0.045).Conclusions One-year moderate aerobic training increased total and right hippocampal volume and protected cognitive function for T2DM patients with normal cognition. Early intervention focusing on cognition protection should be considered for T2DM patients in clinical settings.