bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of three screening tools to predict COVID-19 positivity in emergency department patients
Authors: DiLorenzo Madeline A , Davis Megan R , Dugas Julianne N , Nelson Kerrie P , Hochberg Natasha S , Ingalls Robin R , Mishuris Rebecca Grochow , Schechter-Perkins Elissa M 
Published: January 2023

BackgroundCOVID-19 symptoms vary widely. This retrospective study assessed which of three clinical screening tools—a nursing triage screen (NTS), an ED review of systems (ROS) performed by physicians and physician assistants and a standardised ED attending (ie, consultant) physician COVID-19 probability assessment (PA)—best identified patients with COVID-19 on a subsequent reverse transcription PCR (RT-PCR) confirmation.MethodsAll patients admitted to Boston Medical Center from the ED between 27 April 2020 and 17 May 2020 were included. Sensitivity, specificity and positive predictive value (PPV) and negative predictive value (NPV) were calculated for each method. Logistic regression assessed each tool’s performance.ResultsThe attending physician PA had higher sensitivity (0.62, 95% CI 0.53 to 0.71) than the NTS (0.46, 95% CI 0.37 to 0.56) and higher specificity (0.76, 95% CI 0.72 to 0.80) than the NTS (0.71, 95% CI 0.66 to 0.75) and ED ROS (0.62, 95% CI 0.58 to 0.67). Categorisation as moderate or high probability on the ED physician PA was associated with the highest odds of having COVID-19 in regression analyses (adjusted OR=4.61, 95% CI 3.01 to 7.06). All methods had a low PPV (ranging from 0.26 for the ED ROS to 0.40 for the attending physician PA) and a similar NPV (0.84 for both the NTS and the ED ROS, and 0.89 for the attending physician PA).ConclusionThe ED attending PA had higher sensitivity and specificity than the other two methods, but none was accurate enough to replace a COVID-19 RT-PCR test in a clinical setting where transmission control is crucial. Therefore, we recommend universal COVID-19 testing prior to all admissions.
Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences
Authors: Chen Shuling , Huang Cheng , Liao Guanrui , Sun Huichuan , Xie Yubin , Liao Changyi , Wang Jianping , He Minghui , Hu Huanjing , Dai Zihao , Ren Xiaoxue , Zeng Xuezhen , Lin Zhilong , Zhang Guo-Pei , Xie Wenxuan , Shen Shunli , Li Shaoqiang , Peng Sui , Kuang Dong-Ming , Zhao Qiang , Duda Dan G , Kuang Ming 
Published: January 2023

ObjectiveRevealing the single-cell immune ecosystems in true versus de novo hepatocellular carcinoma (HCC) recurrences could help the optimal development of immunotherapies.DesignWe performed 5’and VDJ single-cell RNA-sequencing on 34 samples from 20 recurrent HCC patients. Bulk RNA-sequencing, flow cytometry, multiplexed immunofluorescence, and in vitro functional analyses were performed on samples from two validation cohorts.ResultsAnalyses of mutational profiles and evolutionary trajectories in paired primary and recurrent HCC samples using whole-exome sequencing identified de novo versus true recurrences, some of which occurred before clinical diagnosis. The tumour immune microenvironment (TIME) of truly recurrent HCCs was characterised by an increased abundance in KLRB1+CD8+T cells with memory phenotype and low cytotoxicity. In contrast, we found an enrichment in cytotoxic and exhausted CD8+T cells in the TIME of de novo recurrent HCCs. Transcriptomic and interaction analyses showed elevated GDF15 expression on HCC cells in proximity to dendritic cells, which may have dampened antigen presentation and inhibited antitumour immunity in truly recurrent lesions. In contrast, myeloid cells’ cross talk with T cells-mediated T cell exhaustion and immunosuppression in the TIME ofde novorecurrent HCCs. Consistent with these findings, a phase 2 trial of neoadjuvant anti-PD-1 immunotherapy showed more responses in de novo recurrent HCC patients.ConclusionTrue and de novo HCC recurrences occur early, have distinct TIME and may require different immunotherapy strategies. Our study provides a source for genomic diagnosis and immune profiling for guiding immunotherapy based on the type of HCC recurrence and the specific TIME.
Chemical Synthesis of Bismuth Oxide and Its Ionic Conversion to Bismuth Sulphide for Enhanced Electrochemical Supercapacitor Energy Storage Performance
Authors: Danamah Hamdan M. , Raut Siddheshwar D. , Shaikh Zeenat A. , Mane Rajaram S. 
Published: January 2023

Successive ionic layer adsorption and reaction (SILAR)-based room-temperature (27 °C) chemical synthesis of bismuth oxide (Bi2O3) and its ionic conversion to bismuth sulphide (Bi2S3) has been performed and reported in the present study. A chemical conversion of the bismuth oxide to the bismuth sulphide has been confirmed using changes in the structure, phase, surface elementals , and surface area measurement studies. Both bismuth oxide and bismuth sulphide electrode materials are envisaged in electrochemical measurements wherein, the later has evidenced an enhanced electrochemical performance over the prior. The cycling stability of the Bi2S3 (91% after 2000 cycles) electrode material is also better than the Bi2O3 (87% over 2000 cycles). The as-assembled Bi2S3//Bi2S3 symmetric electrochemical supercapacitor device has adduced 75.3 Wh kg−1 and 749.8 W Kg−1energy and power densities, respectively with nearly 88.8% capacitance retention efficacy even over 2000 redox cycles measured at 10 A g−1. The commercial potential of the Bi2S3//Bi2S3 has been tested by powering the display panel “CNED” consisting nearly 42 LEDs with a full-light intensity.
Stimulated Raman Scattering Microscopy Enables Gleason Scoring of Prostate Core Needle Biopsy by a Convolutional Neural Network
Authors: Ao Jianpeng , Shao Xiaoguang , Liu Zhijie , Liu Qiang , Xia Jun , Shi Yongheng , Qi Lin , Pan Jiahua , Ji Minbiao 
Published: January 2023

AbstractFocal therapy (FT) has been proposed as an approach to eradicate clinically significant prostate cancer while preserving the normal surrounding tissues to minimize treatment-related toxicity. Rapid histology of core needle biopsies is essential to ensure the precise FT for localized lesions and to determine tumor grades. However, it is difficult to achieve both high accuracy and speed with currently available histopathology methods. Here, we demonstrated that stimulated Raman scattering (SRS) microscopy could reveal the largely heterogeneous histologic features of fresh prostatic biopsy tissues in a label-free and near real-time manner. A diagnostic convolutional neural network (CNN) built based on images from 61 patients could classify Gleason patterns of prostate cancer with an accuracy of 85.7%. An additional 22 independent cases introduced as external test dataset validated the CNN performance with 84.4% accuracy. Gleason scores of core needle biopsies from 21 cases were calculated using the deep learning SRS system and showed a 71% diagnostic consistency with grading from three pathologists. This study demonstrates the potential of a deep learning–assisted SRS platform in evaluating the tumor grade of prostate cancer, which could help simplify the diagnostic workflow and provide timely histopathology compatible with FT treatment.Significance:A platform combining stimulated Raman scattering microscopy and a convolutional neural network provides rapid histopathology and automated Gleason scoring on fresh prostate core needle biopsies without complex tissue processing.
Short and Long-Term Prognostic Significance of Galectin-3 in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Köktürk Uğur , Püşüroğlu Hamdi , Somuncu Mustafa Umut , Akgül Özgür , Uygur Begüm , Özyılmaz Sinem , Işıksaçan Nilgün , Sürgit Özgür , Yıldırım Aydın 
Published: January 2023

This study evaluated the short and long-term prognostic value of galectin-3 in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Patients (n = 143) were admitted with STEMI and followed up for 2 years. The study population was divided into high and low galectin-3 groups based on the admission median value of serum galectin-3. Primary clinical outcomes consisted of cardiovascular (CV) mortality, non-fatal reinfarction, stroke, and target vessel revascularization (TVR). CV events were recorded in hospital and at 1 and 2 years. The primary clinical outcomes (in-hospital, 1 year and 2 year) were significantly higher in the high galectin-3 group. ( P = .008, P = .004, P = .002, respectively). High galectin-3 levels were also associated with heart failure development and re-hospitalization at both 1 year ( P = .029, P = .009, respectively) and 2 years ( P = .019, P = .036, respectively). According to Cox multivariate analysis, left ventricular ejection fraction (LVEF) was an independent predictor of 2-year cardiovascular mortality ( P = .009), whereas galectin-3 was not ( P = .291). Although high galectin-3 levels were not independent predictors of long-term CV mortality in patients with acute STEMI who underwent primary PCI, it was associated with short-term and long-term development of adverse CV events, heart failure, and re-hospitalization.
A 3D printed liquid metal emulsion for low stress activated stretchable electronics
Authors: Sánchez Cruz Ramón E , Zopf Stephanie F , Boley J William 
Published: January 2023

A strain-induced electrically conductive liquid metal emulsion for the programmable assembly of soft conductive composites is reported. This emulsion exhibits the shear yielding and shear thinning rheology required for direct ink writing. Examples of complex self-supported 3D printed structures with spanning features are presented to demonstrate the 3D printability of this emulsion. Stretchable liquid metal composites are fabricated by integrating this emulsion into a multi-material printing process with a 3D printable elastomer. The as-printed composites exhibit a low electrical conductivity but can be transformed into highly conductive composites by a single axial strain at low stresses ([Formula: see text] 0.3 MPa), an order of magnitude lower than other mechanical sintering approaches. The effects of axial strain and cyclic loading on the electrical conductivities of these composites are characterized. The electrical conductivity increases with activation strain, with a maximum observed relaxed conductivity of 8.61 × 105 S⋅m−1, more than 300% higher than other mechanical sintering approaches. The electrical conductivity of these composites reaches a steady state for each strain after one cycle, remaining stable with low variation ([Formula: see text] standard deviation) over 1000 cycles. The strain sensitivities of these composites are quantitatively analyzed. All samples exhibit strain sensitivities that are lower than a bulk conductor throughout all strains. The printed composites showed low hysteresis at high strains, and high hysteresis at low strains, which may be influenced by the emulsion internal structure. The utility of these composites is shown by employing them as wiring into a single fabrication process for a stretchable array of LEDs.
A 2-Year Follow-up May Not be Enough to Accurately Evaluate Recurrences After Arthroscopic Bankart Repair: A Long-term Assessment of 272 Patients With a Mean Follow-up of 10.5 Years
Authors: Rossi Luciano Andrés , Pasqualini Ignacio , Huespe Iván , Brandariz Rodrigo , Fieiras Cecilia , Tanoira Ignacio , Ranalletta Maximiliano 
Published: January 2023

Background: There is a great discrepancy between the rates of recurrent instability reported after arthroscopic Bankart repair in relation to the follow-up time. Purpose: To analyze the rate of recurrences after arthroscopic Bankart repair in the long term, emphasizing whether a minimum follow-up of 2 years is adequate to assess this outcome. Study Design: Case series; Level of evidence, 4. Methods: Between January 2008 and April 2013, a total of 356 athletes underwent arthroscopic Bankart repair for anterior glenohumeral instability at our institution. Return to sports, the Rowe score, the Subjective Shoulder Value (SSV), and the Athletic Shoulder Outcome Scoring System (ASOSS) were used to assess functional outcomes. We analyzed the proportion of recurrences before and after 4 years of follow-up. Additionally, we performed a Kaplan-Meier analysis to evaluate recurrence-free time in patients with a recurrence. Results: The mean follow-up was 10.5 ± 1.6 years, and the mean age was 20.8 ± 3.9 years. In total, 90% of patients were able to return to sports; of these, 91% returned to their preinjury level of play. The Rowe, SSV, and ASOSS scores showed a statistical improvement after surgery ( P < .01). The proportion of patients with a recurrence during the follow-up period was 25% (95% CI, 20%-31%; n = 70), and the mean time until a recurrence was 3.8 ± 2.6 years. Only 39% of the recurrences (95% CI, 30%-48%) occurred in the first 2 years after surgery, while 61% (95% CI, 50%-73%) occurred in the first 4 years after surgery. Conclusion: In our study, the effectiveness of Bankart repair to stabilize the shoulder decreased significantly over time. Indeed, less than half of the recurrences occurred after 2 years of follow-up. Therefore, we propose that the recommended minimum follow-up should be 4 years; otherwise, it is very likely that the actual rate of recurrences will be significantly underestimated.
The Influence of Industry Affiliation on Randomized Controlled Trials of Platelet-Rich Plasma for Knee Osteoarthritis
Authors: Ta Canhnghi N. , Vasudevan Rajiv , Mitchell Brendon C. , Keller Robert A. , Kent William T. 
Published: January 2023

Background: Industry funding and corporate sponsorship have played a significant role in the advancement of orthopaedic research and technology. However, this relationship raises concerns for how industry association may bias research findings and influence clinical practice. Purpose: To determine whether industry affiliation plays a role in the outcomes of randomized controlled trials (RCTs) investigating platelet-rich plasma (PRP). Study Design: Meta-analysis; Level of evidence, 2. Methods: A search of the PubMed, Cochrane, and MEDLINE databases for RCTs published between 2011 and the present comparing PRP versus hyaluronic acid, corticosteroid, or placebo for the treatment of knee osteoarthritis was performed. To determine industry affiliation, the conflict of interest, funding, and disclosure sections of publications were assessed, and all authors were assessed through the American Academy of Orthopaedic Surgeons disclosure database and the Centers for Medicare & Medicaid Services open payments database. Studies were classified as industry affiliated (IA) or non–industry affiliated (NIA). The outcomes of each study were rated as favorable, analogous, or unfavorable according to predefined criteria. Results: A total of 37 studies (6 IA and 31 NIA) were available for analysis. Overall, 19 studies (51.4%) reported PRP as favorable compared with other treatment options, while 18 studies (48.6%) showed no significant differences between PRP and other treatment methods. There was no significant difference in qualitative conclusions between the IA and NIA groups, with the IA group having 3 favorable studies and 3 analogous studies and the NIA group having 16 favorable studies and 15 analogous studies ( P = .8881). When comparing IA versus NIA studies using 6- and 12-month Western Ontario and McMaster Universities Arthritis Index and International Knee Documentation Committee scores, there were no significant differences in outcomes. Conclusion: The results of this study demonstrated that qualitative conclusions and outcome scores were found to not be associated with industry affiliation. Although the results of this study suggest that there is no influence of industry involvement on RCTs examining PRP, it is still necessary to carefully evaluate pertinent commercial affiliations when reviewing recommendations from studies before adopting new treatment approaches, such as the use of PRP for knee osteoarthritis.
Assessment of a Suicide Prevention Gatekeeper Training Program for Nursing Home Staff
Authors: Demesmaeker Alice , Baelde Nicolas , Amad Ali , Roche Jean , Playe Marie , Vaiva Guillaume , Amariei Alina , Blervaque Wanda , Defebvre Marguerite Marie , Caron Brigitte , Puisieux Francois , Plancke Laurent 
Published: January 2023

Introduction Older adults have one of the highest age‐specific suicide rates in France, and the risk of suicide is higher for those living in nursing homes. The aim of our study was to assess the effectiveness of gatekeeper training for nursing home staff on the knowledge and stigmas towards suicidal crisis and the impact on suicidal behaviour rates. Method A total of 427 nursing or administrative staff from 110 nursing homes received gatekeeper training in the Hauts-de-France French region between September 2016 and June 2018. First, knowledge and stigmas on suicidal crisis were assessed through a pretest and posttest survey. Second, a retrospective survey was conducted to determine suicide behaviour rates before and after training in nursing homes. Then, changes between pre- and posttraining scores and suicide rates were evaluated with a paired samples T test and rate difference calculation ( P value of <0.05 was considered statistically significant). Results A total of 315 trainees completed the questionnaires on knowledge and stigmas related to suicidal crisis, and we found a significant difference in the total scores ( P < 0.01). Moreover, we found a significant decrease in the incidence of suicide attempts (SAs) after training ( P = 0.002), but the incidence of deaths by suicide was not significantly different prior to and after the training course ( P = 0.46). Conclusion We highlighted an improvement in knowledge and stigmas after training and a reduction in the rates of SAs with our gatekeeper suicide prevention program. Future research is needed to improve suicide prevention for nursing home residents.
Attitude path design and adaptive robust tracking control of a remote sensing satellite in various imaging modes
Authors: Zarourati Mohammad , Mirshams Mehran , Tayefi Morteza 
Published: January 2023

This paper addresses the attitude path design of a remote sensing satellite in various imaging modes. The novel path design algorithm is based on local polynomial regression, which produces a smooth attitude path by receiving the size and timing of maneuvers in each axis according to the desired imaging mode. This algorithm is described for stereo and snapshot modes in an imaging operation. The adaptive robust tracking control (ARTC) law is designed using quaternion algebra to perform the required maneuvers in an attitude path. The ARTC structure includes a sliding mode strategy, a projection-based adaptive model compensation, and a linear feedback term. Suitable conditions for imaging in each mode and the time of taking the image are determined by defining and evaluating the attitude control indices. These indices are defined by the half-cone error along the payload line of sight and relative performance error as a jitter with a 3-sigma confidence level. Despite the challenges in the path design, such as smoothness, system agility, and finite time realization of indices, in a conventional stereo imaging mode, taking an image in the nadir-pointing attitude is neglected. As a result, our work provides suitable conditions for taking the image in this attitude with an interval of 1.2 s. Finally, numerical simulations and verification are performed using multidisciplinary simulation, indicating the effectiveness of the proposed algorithm and model-based ARTC law.
The association of serum magnesium with infection in new-onset systemic lupus erythematosus patients
Authors: Yang Wenfang , Lian Xuejian , Chen Hongpu 
Published: January 2023

Objective To assess the association of serum magnesium with infection in new-onset systemic lupus erythematosus (SLE) patients. Methods We conducted a single-center retrospective cohort study of new-onset SLE patients from 2012 to 2021. The hospitalized SLE patients were divided into infection and noninfection groups. Logistic regression analysis was conducted to examine the association of hypomagnesemia with infection. Results A total of 476 new-onset SLE patients were included, with 299 cases in the infection group and 177 cases in the noninfection group. The patients were mostly females (81.7%). The average age at diagnosis was 43.7 years. The median duration was 1.0 month. The prevalence of hypomagnesemia (<0.70), normomagnesemia (0.70–1.10), and hypermagnesemia (>1.10) in new-onset SLE patients was 14.3%, 83.4%, and 2.3%, respectively. The prevalence of hypomagnesemia was 18.4% in the infection group and 7.3% in the noninfection group ( p = .001). The baseline value of serum magnesium was 0.819 mmol/L, with values of 0.799 mmol/L in the infection group and 0.854 mmol/L in the noninfection group ( p = .000). The following clinical variables were significantly different between the two groups ( p < .05): age, duration, hospitalization stay, fever, serositis, and SLE Disease Activity Index 2000 (SLEDAI 2K). The laboratory parameters, including hemoglobin, white blood cell count, albumin level, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin, and complement C3 were also significantly different between the two groups ( p < .05). The mortality was 4.4% (21/476), with 20 cases occurring in the infection group. Logistic regression analysis showed that hypomagnesemia was associated with an increased risk of infection ( p = .001) and poor prognosis ( p = .015). Conclusion Hypermagnesemia was rare in new-onset SLE patients. Hypomagnesemia was common and was associated with an increased risk of infection in new-onset SLE patients.
Caring for family members following suicide: Professionals’ experiences of responsibility
Authors: Vatne May Elise , Nåden Dagfinn , Lohne Vibeke 
Published: January 2023

Background When a patient commits suicide while hospitalized in the psychiatric ward, the mental healthcare professionals (MHCPs) who have had the patient in their care encounter the family members immediately following the suicide. Professionals who encounter the bereaved in this first critical phase may have a significant impact on the grieving process. By providing ethically responsible and professionally competent care, they have the opportunity to influence what can alleviate and reduce suffering and promote health in a longer perspective. Aim The aim of this study is to investigate MHCPs’ experiences in the encounter with family members who has been bereaved by suicide. Methods Data material consists of text from in-depth interviews with six MHCPs belonging to a total of five different psychiatric units in two hospitals. The findings have emerged through analysis using a hermeneutical approach based on Gadamer’s philosophical hermeneutics. Ethical considerations The study was approved by the Ombudsman for Privacy of the Norwegian Social Science Data Services and is based on informed consent and confidentiality. Findings Three themes emerged: Confirming the suffering. Creating encounter through dialogue. Providing consolation and reconciliation. Findings illuminate how MHCPs understand their responsibilities and how they act in the encounter with the bereaved following suicide. Conclusion The participants appear to be led by the responsibility that grows through witnessing the suffering of the bereaved. Encountering the family member’s aggression and threats against staff members is an ethical challenge to the professional’s ability to confirm the bereaved, create dialogue and provide consolation and reconciliation at the start of their grieving process. MHCPs need to be aware of the different reactions and needs of family members following suicide. More research is needed about how to provide sensitive and flexible care in ways that can be perceived as helpful for those left behind.