bluuebunny/crossref_metadata_2025_split huggingface dataset:
METODE PEMBELAJARAN SIMULASI DAN HUKUMAN GANJARAN TERHADAP PEMBENTUKAN KARAKTER SISWA
Authors: Maria Ulfa Siregar  
Published: June 2023

Penelitian ini merupakan Penelitian Tindakan Kelas (PTK), penelitian ini dilakukan karena ditemukannya masalah-masalah yang timbul dalam kelas, yaitu kurangnya keaktifan siswa dalam mengemukakan pendapat dalam proses pembelajaran yang sedang berlangsung. Hal ini disebabkan oleh guru kurang menggunakan model pembelajaran yang tepat dan bervariasi untuk meningkatkan keaktifan siswa dalam mengemukakan pendapat. Penelitian Tindakan Kelas (PTK) dilakukan dalam dua siklus, dimana setiap siklus dilakukan 1 kali pertemuan, setiap siklusnya memiliki 4 tahapan yaitu: perencanaan, pelaksanaan, pengamatan dan refleksi. Adapun alat pengumpulan data dalam penelitian ini adalah observasi dan tes. Berdasarkan pengamatan pada siklus I yaitu: 519,% (sekitar 30 siswa). Hal ini menunjukkan bahwa observasi pada siklus I belum optimal, maka dari itu dilakukan pengamatan pada siklus II. Berdasarkan pengamatan pada siklus II, hasil pengamatannya adalah 580% (sekitar 36 siswa). Hal ini menunjukkan siklus II sudah mencapai tujuan yang diharapkan yaitu siswa sudah lebih aktif dalam proses pembelajaran. Pengaruh model pembelajaran simulasi dan hukuman dan ganjaran masalah telah membuktikan peningkatan keaktifan siswa dalam mengemukakan pendapat, hal ini dilihat dari hasil analisis dan pengolahan data dan model pembelajaran simulasi dan hukuman ganjaran(X) dengan keaktifan siswa dalam mengemukakan pendapat (Y), Dengan demikian menunjukkan adanya observasi dan tes pengaruh model pembelajaran simulasi dan hukuman ganjaran terhadap pembentukan karakter siswa.
MODEL PEMBELAJARAN COURSE REVIEW HORAY (CRH) UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR
Authors: Afriza Br Purba  
Published: June 2023

Tujuan penelitian ini adalah: “Untuk mengetahui penerapan model pembelajaran Course Review Horay, apakah dapat meningkatkan motivasi dan hasil belajar PPKn siswa kelas XI IPS 2 SMA Negeri 5 Tanjung Balai Tahun Pelajaran 2018 / 2019”. Subjek penelitian ini adalah seluruh siswa kelas XI SMA Negeri 5 Tanjung Balai yang berjumlah 30 siswa. Yang menjadi objek dalam penelitian ini adalah adalah tindakan sebagai penerapan model pembelajaran Course Review Horay untuk meningkatkan motivasi dan hasil belajar PPKn. Bentuk penelitian ini adalah penelitian tindakan kelas yang berlangsung dalam dua siklus. Setiap siklus terdiri dari 4 tahapan yaitu, perencanaan, pelaksanaan, pengamatan, dan refleksi. Teknik pengumpulan data yang digunakan adalah observasi dan tes. Hasil penelitian ini menunjukkan bahwa model pembelajaran Course Review Horay dapat meningkatkan Motivasi dan Hasil Belajar siswa pada mata pelajaran PPKn kelas XI SMA Negeri 5 Tanjungbalai.Peningkatan tersebut dapat dilihat dari motivasi siswa pada setiap siklusnya yaitu pada siklus I 52,91% dan pada siklus II 84,16%. Untuk peningkatan hasil belajar siswa pada siklus I menunjukkan 17 dari 30 siswa telah tuntas belajar persentase 56.66% dan pada siklus II 27 dari 30 siswa telah tuntas belajar dengan persentase 90%. Dari hasil tersebut menunjukkan bahwa model pembelajaran Course Review Horay dapat meningkatkan motivasi dan hasil belajar siswa pada mata pelajaran PPKn kelas XI SMA Negeri 5 Tanjung Balai. Dengan kata lain hipotesis yang diajukan dapat diterima kebenarannya.
PENDEKATAN SAINTIFIK MENGGUNAKAN MODEL PEMBELAJARAN DISCOVERY LEARNING UNTUK MENINGKATKAN HASIL BELAJAR
Authors: Nurul Liza Amini  
Published: June 2023

Penelitian ini merupaka Penelitan Tindakan Kelas, konsepnya adalah mengamati, menanya, menalar, mencoba, mencipta, menyajikan, dan mengkomunikasikan. Rumusan masalah dalam penelitian ini adalah “Apakah pendekatan saintifik menggunakan model pembelajaran Discovery Learning dapat meningkatkan hasil belajar siswa pada mata pelajaran PPKn di kelas X SMK Negeri 1 Galang?”. Subjek dalam penelitian ini adalah kelas X TKJ II yang terdiri dari 30 orang siswa didalamnya. Objek penelitian ini adalah hasil belajar siswa dengan pendekatan Saintifik menggunakan model pembelajaran Discovery Learning. Berdasarkan latar belakang masalah diatas maka tujuan sebagai berikut “Untuk Mengetahui Apakah Pendekatan Saintifik Menggunakan Model Pembelajaran Discovery Learning dapat Meningkatkan Hasil Belajar Siswa pada Mata Pelajaran PPkn Di Kelas X SMK Negeri 1 Galang T.P 2019/2020?”. Dari hasil penelitian, pendekatan Saintifik menggunakan model pembelajaran Discovery Learning memiliki dampak positif untuk meningkatkan hasil belajar siswa, ditandai dengan ketuntasan hasil belajar dalam setiap Siklus, yaitu dalam Siklus I nilai ketuntasan seluruh siswa adalah 60%, dan pada Siklus ke II nilai ketuntasan hasil belajar seluruh siswa meningkat menjadi 86,6% karena seluruh siswa sudah memahami model pembelajaran Discovery Learning tersebut. Dari hasil penelitian ini dapat disimpulkan bahwa pendekatan saintifik menggunakan model pembelajaran discovery learning ini sangat efektif digunakan di kelas X TKJ II SMK Negeri 1 Galang, dengan kata lain hipotesis yang diajukan sebelumnya dapat diterima kebenarannya.
Trouble In Paradise: Improving The Discoverability Of Circum-Caribbean Materials Through Enhanced Cataloguing Practices
Authors: Gooding Alexandra 
Published: June 2023

<p> This thesis examines how the Circum-Caribbean region’s cultural and geographic complexity make it difficult to describe or index materials relevant to this region using mainstream authority controls available in galleries, libraries, archives, and museums (GLAMs). The majority of widely used controls in GLAMs have Western-centralised worldviews and are rigid in nature, thereby incapable of accommodating the fluidity necessary to accurately denote the complex Circum-Caribbean. This paper applies methodologies to the Getty Thesaurus of Geographic Names and the West Indian Postcard Collection at the Cambridge University Library’s Royal Commonwealth Society department to argue that expanding the vocabulary and applications of an authority control can improve the discoverability of collection materials pertinent to the Circum-Caribbean. My results and observations coupled with brief reviews of two bespoke authority controls lead to recommendations on how to improve authority controls, particularly how to decolonise them and improve their usability for non-Western places and cultures. </p>
Mechanisms of Improving the Thermal and Electrical Conductivity of Aluminum Alloy Cylinder Heads
Authors: Vandersluis Eli 
Published: June 2023

<p>One of the major causes of premature failure in automotive cylinder heads is the accumulation of thermal stresses, due to their large internal temperature gradients in-service. To ensure mechanical integrity, engine operating temperatures are typically restricted. However, this response reduces fuel efficiency, which increases costs and carbon emissions. A more sustainable solution can involve enhancing alloy conductivity, which improves temperature uniformity in the heads. In aluminum alloys, solidification rate, silicon modification, and precipitation heat treatment have each been reported to influence conductivity. Yet, the mechanisms and interactions regarding these parameters were unclear in the literature. Accordingly, the objective of this dissertation was to provide an in-depth, systematic investigation of the individual and combined effects of these processes on the microstructure and conductivity of automotive 319 aluminum alloy.</p>
<p>After performing a baseline characterization of commercial cylinder heads, permanent-mould castings were produced with a range of solidification rates and strontium contents. These castings were analyzed to establish the dominant microstructural factors affecting electron mobility in the as-cast condition. Then, samples were subjected to multiple combinations of solution, natural aging, artificial aging, and direct aging heat treatments, to elucidate the roles of the dissolution, spheroidization and precipitation transformations. Furthermore, this work was complimented by several innovative, state-of-the-art experiments, which were the first to analyze the kinetics of solidification, chemical modification, thermal expansion, dissolution, and precipitation in 319. As a result, this dissertation contributed numerous, novel and meaningful insights regarding heat transfer in aluminum alloys. This included elucidation of the independent, major impacts of porosity, silicon morphology, and the size, distribution and coherency of the aluminum-copper precipitates, despite insensitivity to the dendritic size. The appropriate combination of solidification rate, strontium content, and heat treatment was demonstrated to promote superior conductivity to what was possible through their individual variation. Given low-porosity castings, this research revealed the potential for approximately 40% improvements in thermal and electrical conductivity, compared to the strontium-free, as-cast condition. Overall, the extensive conductivity data generated in this research supports strategic and practical materials processing procedures, demonstrates opportunities for balancing high conductivity with mechanical integrity, and ensures enhanced component performance and environmental sustainability.</p>
Kirja, joka sinun todennäköisesti olisi syytä lukea
Authors: Hämäri Severi 
Published: June 2023

Teos pureutuu tutkimusperustaisesti erityisesti suomalaiseen rasismiin ja sen vastaiseen työhön. Tehtävä on kaikkea muuta kuin helppo, sillä Suomessa rasismia kuten seksismiäkään ei oikein osata tunnistaa saati tunnustaa. Kirja on yksi parhaimpia lukemiani esityksiä rasismin sekä antirasismin ja -kolonialismin tutkimuksen perinteessä, jonka teoreettinen viitekehys on raskas ja usein vaikeaselkoinen siihen aiemmin perehtymättömälle.
A novel compound heterozygous variant in ALPK3 induced hypertrophic cardiomyopathy: a case report
Authors: Li Tiange , Jin Yuxi , Liu Rui , Hua Yimin , Zhou Kaiyu , Luo Shuhua , Li Yifei , Zhang Donghui 
Published: June 2023

BackgroundMalignant hypertrophic cardiomyopathy (HCM) phenotypes have potential risks of severe heart failure, fatal arrhythmia, and sudden cardiac death. Therefore, it is critical to predict the clinical outcomes of these patients. It was reported recently that the alpha kinase 3 (ALPK3) gene was involved in the occurrence of HCM. Herein we reported a girl with HCM, while whole-exome sequencing found novel compound heterozygous variants in ALPK3 gene, which identified a potential association.Case presentationWe reported a 14-year-girl who suffered from clinical manifestations of cardiac failure, with sudden cardiac arrest before admission. The heartbeat recovered after cardiopulmonary resuscitation, though she remained unconscious without spontaneous breath. The patient stayed comatose when she was admitted. Physical examination indicated enlargement of the heart boundary. Laboratory results revealed a significant increment of myocardial markers, while imaging demonstrated hypertrophy of the left heart and interventricular septum. Whole-exome sequencing (WES) identified a compound heterozygous variant in ALPK3 gene consisting of c.3907_3922del and c.2200A&gt;T, which was inherited from her parents. Both variants (p.G1303Lfs*28 and p.R734*) were disease-causing evaluated by MutationTaster (probability 1.000). The crystal structure of the complete amino acid sequence is predicted and evaluated by AlphaFold and SWISS-MODEL software (July, 2022), which revealed three domains. Moreover, both variants resulted in a wide protein-truncating variant and damaged protein function. Thus, a novel compound heterozygous variant in ALPK3 associated with HCM was diagnosed.ConclusionWe described a young patient with ALPK3-associated HCM who experienced sudden cardiac arrest. Through WES, we identified a compound heterozygous variant in the ALPK3 gene, c.3907_3922del and c.2200A&gt;T, which were inherited from the patient's parents and resulted in a truncated protein, indirectly causing the symptoms of HCM. In addition, WES provided clues in evaluating potential risks of gene variants on fatal clinical outcomes, and the nonsense and frameshift variants of ALPK3 were related to adverse clinical outcomes in HCM patients, which required implantable cardioverter defibrillator (ICD) timely.
A first high-resolution carbon isotope stratigraphy from the Boreal (NW Germany) for the Berriasian to Coniacian interval—implications for the timing of the Aptian–Albian boundary
Authors: Bornemann André , Erbacher Jochen , Blumenberg Martin , Voigt Silke 
Published: June 2023

High-amplitude changes in sedimentary δ13C characterize the Cretaceous system and have been proven useful for supra-regional chemostratigraphic correlation. In the Cretaceous, these δ13C perturbations indicate large shifts between the global carbon reservoirs that are usually caused by volcanic activity of large igneous provinces, the widespread deposition of thick organic carbon-rich sequences and/or changes in orbital parameters. Here, we present an upper Berriasian to lower Coniacian (c. 142–88 Ma) composite carbon isotope record based on 14 drill cores, 2 outcrops, and almost 5,000 samples. The total record comprises a composite thickness of more than 1,500 m. All cores and successions are located in the larger Hanover area, which represents the depocenter of the North German Lower Saxony Basin in Early to mid-Cretaceous times. In Northern Germany, Boreal Lower Cretaceous sediments are predominantly represented by CaCO3-poor mud and siltstones of up to 2,000 m thickness, which become more carbonate-rich during the Albian–Cenomanian transition and even chalkier in the upper Cenomanian to Coniacian interval. The carbon isotope record reveals a number of global key events, including the Valanginian Weissert Event, the Oceanic Anoxic Events (OAEs) 1a and d, and the Kilian Event (Aptian–Albian boundary, part of OAE 1b). For the early Late Cretaceous, the Mid-Cenomanian Event, the OAE 2 (Cenomanian–Turonian Boundary Event), and the Navigation Event, among others, have been identified. The Kilian Event represents the Aptian–Albian boundary and has been identified herein for the first time in Northern Europe. Based on the evaluation of its relative position to the Vöhrum boundary tuff, we tentatively propose a slightly older age for the Aptian–Albian boundary of c. 113.65 Ma instead of 113.2 Ma. The observed chemostratigraphic events enable a detailed stratigraphic comparison with Tethyan and other Boreal records and associated paleoenvironmental data. Thus, this new detailed chemostratigraphy provides a unique opportunity to potentially overcome many still existing Boreal–Tethyan correlation issues. The presented record can be considered almost complete, albeit a 2-Myr gap during the early Albian is likely, and condensed intervals occur specifically during the lower Aptian.
Firing mechanism and benefit evaluation of high-strength fired water permeable brick containing vanadium-titanium iron ore tailings
Authors: Bao Pingju , Jing Jianlin , Qi Yang , Ma Jintao , Ping Haoyan , Wang Changlong , Liu Zhibing , Zheng Yongchao , Zhai Yuxin , Liu Feng 
Published: June 2023

Introduction: The vanadium-titanium iron ore tailings (VTIOTs) has a significant amount of discharge, and serious pollution, which makes it difficult to use directly as a resources resource.Methods: High-strength fired water permeable brick (HSFWPB) was prepared using VTIOTs as the main raw material. The orthogonal test, X-ray diffraction analysis (XRD), scanning electron microscope (SEM), energy dispersive spectrometry (EDS), and synthetic precipitation leaching procedure (SPLP) were obtained to study the basic properties and firing mechanism of HSFWPB containing VTIOTs, and an economic benefit evaluation was conducted on the project investment of HSFWPB containing VTIOTs.Results: The results show that when the content of VTIOTs in HSFWPB is 78%, the firing temperature (FT) is 1080°C and the holding time is 120 min, the compressive strength and permeability coefficient of the fired product reach 70.4 MPa and 0.055 cmˑs−1, respectively, which meet the requirements of Cc60 grade products in Water permeable brick (JC/T 945–2005). The products of HSFWPB containing VTIOTs after firing are diopside (CaMgSi2O6) and augite (Ca (Mg, Fe, Al) (Si, Al)2O6), with the increase of FT and the extension of HT, the low melting point elements of P, Na, K dissolve out, and the content of Fe and Al in the firing products increases, most of Ca2+ in diopside is replaced by Fe3+, so that augite becomes the main crystal phase. With the increase of FT, the pores in the fired products are changed from: closed pores with different sizes→ connected pores with irregular diameters→ irregular collapse pores→ small and uniform circular pores, which provides a guarantee for the permeability of HSFWPB containing VTIOTs.Discussion: The full investment payback period of the project of HSFWPB containing VTIOTs is 1.77 years. When the production reaches 48.585% of the design output, it reaches a breakeven point, and the project has strong risk resistance ability. The research has improved the utilization rate of VTIOTs and provided a new approach for the large-scale application of VTIOTs.
Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome
Authors: Radhakrishna Uppala , Nath Swapan K. , Uppala Lavanya V. , Veerappa Avinash , Forray Ariadna , Muvvala Srinivas B. , Metpally Raghu P. , Crist Richard C. , Berrettini Wade H. , Mausi Lori M. , Vishweswaraiah Sangeetha , Bahado-Singh Ray O. 
Published: June 2023

Introduction: The neonate exposed to opioids in utero faces a constellation of withdrawal symptoms postpartum commonly called neonatal opioid withdrawal syndrome (NOWS). The incidence of NOWS has increased in recent years due to the opioid epidemic. MicroRNAs (miRNAs) are small non-coding RNA molecules that play a crucial role in gene regulation. Epigenetic variations in microRNAs (miRNAs) and their impact on addiction-related processes is a rapidly evolving area of research.Methods: The Illumina Infinium Methylation EPIC BeadChip was used to analyze DNA methylation levels of miRNA-encoding genes in 96 human placental tissues to identify miRNA gene methylation profiles as-sociated with NOWS: 32 from mothers whose prenatally opioid-exposed infants required pharmacologic management for NOWS, 32 from mothers whose prenatally opioid-exposed infants did not require treat-ment for NOWS, and 32 unexposed controls.Results: The study identified 46 significantly differentially methylated (FDR p-value ≤ 0.05) CpGs associated with 47 unique miRNAs, with a receiver operating characteristic (ROC) area under the curve (AUC) ≥0.75 including 28 hypomethylated and 18 hypermethylated CpGs as potentially associated with NOWS. These dysregulated microRNA methylation patterns may be a contributing factor to NOWS pathogenesis.Conclusion: This is the first study to analyze miRNA methylation profiles in NOWS infants and illustrates the unique role miRNAs might have in diagnosing and treating the disease. Furthermore, these data may provide a step toward feasible precision medicine for NOWS babies as well.
Durability of immune response after SARS-CoV-2 vaccination in patients with chronic liver disease
Authors: Song Ruixin , Yang Chao , Li Qianqian , Wang Jiayin , Chen Jing , Sun Kai , Lv Hongmin , Yang Yankai , Liang Jing , Ye Qing , Gao YanYing , Li Jun , Li Ying , Yan Junqing , Liu Ying , Wang Tao , Liu Changen , Zhu Ping , Wang Fei , Yin Weili , Xiang Huiling 
Published: June 2023

AimThe present study aimed to evaluate the durability of immune response after basic and booster immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with chronic liver disease (CLD).MethodsPatients with CLD and complete basic or booster immunization with SARS-CoV-2 vaccines were included in this study. Based on the vaccination situation, they were divided into the basic immunity group (Basic) and the booster immunity group (Booster), which were then subdivided into four groups according to the time interval from completion of basic immunization or booster immunization to serological specimen collection. The positive rates and antibody titers of novel coronavirus neutralizing antibody (nCoV NTAb) and novel coronavirus spike receptor-binding domain antibody (nCoV S-RBD) were analyzed.ResultsA total of 313 patients with CLD were enrolled in this study, including 201 in Basic and 112 in Booster. The positive rates of nCoV NTAb and nCoV S-RBD within 30 days of completing basic immunization were 80.4% and 84.8%, respectively, but decreased rapidly with the extension of vaccination time, and only 29% and 48.4% of patients with CLD remained positive for nCoV NTAb and nCoV S-RBD, respectively, after 120 days of completing basic immunization. Within 30 days of booster immunization, the positive rates of nCoV NTAb and nCoV S-RBD in patients with CLD rapidly increased from 29.0% and 48.4% at the end of basic immunization to 95.2% and 90.5%, and maintained a high level (defined as the positive rate &gt;50%) until 120 days when the positive rates of nCoV NTAb and nCoV S-RBD were still high at 79.5% and 87.2%, respectively. After basic immunization, the time for nCoV NTAb and nCoV S-RBD to turn negative was 120 and 169 days, respectively, and the negative time of nCoV NTAb and nCoV S-RBD was significantly prolonged to 266 days and 329 days, respectively.ConclusionIt is safe and effective for patients with CLD to complete basic and booster immunization with SARS-CoV-2 vaccines. After booster immunization, the immune response of patients with CLD was further improved and the durability of the SARS-CoV-2 antibody was significantly prolonged.
Predictors for early cardiac death after discharge from successfully treated acute myocardial infarction
Authors: Choi Young , Lee Kwan Yong , Kim Sang Hyun , Kim Kyung An , Hwang Byung-Hee , Choo Eun Ho , Lim Sungmin , Kim Chan Jun , Kim Jin-Jin , Byeon Jaeho , Oh Gyu Chul , Jeon Doo Soo , Yoo Ki Dong , Park Ha-Wook , Kim Min Chul , Ahn Youngkeun , Ho Jeong Myung , Hwang Youngdeok , Chang Kiyuk 
Published: June 2023

BackgroundThe use of a cardioverter defibrillator for the primary prevention of sudden cardiac death is not recommended within 40 days after acute myocardial infarction (AMI). We investigated the predictors for early cardiac death among patients who were admitted for AMI and successfully discharged.MethodsConsecutive patients with AMI were enrolled in a multicenter prospective registry. Among 10,719 patients with AMI, 554 patients with in-hospital death and 62 patients with early non-cardiac death were excluded. Early cardiac death was defined as a cardiac death within 90 days after index AMI.ResultsEarly cardiac death after discharge occurred in 168/10,103 (1.7%) patients. A defibrillator was not implanted in all patients with early cardiac death. Killip class ≥3, chronic kidney disease stage ≥4, severe anemia, cardiopulmonary support usage, no dual antiplatelet therapy at discharge, and left ventricular ejection fraction (LVEF) ≤35% were independent predictors for early cardiac death. The incidence of early cardiac death according to the number of factors added to LVEF criteria in each patient was 3.03% for 0 factor, 8.11% for 1 factor, and 9.16% for ≥2 factors. Each model that sequentially added the factors in the presence of LVEF criteria showed a significant gradual increase in predictive accuracy and an improvement in reclassification capability. A model with all factors showed C-index 0.742 [95% CI 0.702–0.781], p &lt; 0.001; IDI 0.024 [95% CI 0.015–0.033], p &lt; 0.001; and NRI 0.644 [95% CI 0.492–0.795], p &lt; 0.001.ConclusionWe identified six predictors for early cardiac death after discharge from AMI. These predictors would help to discriminate high-risk patients over current LVEF criteria and to provide an individualized therapeutic approach in the subacute stage of AMI.