bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal Serum Gentamicin Concentrations and Outcomes Following Maternal Once-Daily Gentamicin Dosing
Authors: Wilson Genene Alexis , Bondi Deborah S. , Shah Pooja A. , Nelson Allison , Kumar Madan , Bhagat Palak H. 
Published: August 2023

OBJECTIVE
This study evaluated newborn gentamicin serum concentrations after birth and the effects on the newborn after extended interval gentamicin dosing in peripartum mothers.

METHODS
This was a single-center, retrospective chart review of neonates born to mothers that received peripartum once-daily gentamicin dosing of approximately 5 mg/kg within 12 hours of delivery. A gentamicin serum concentration was obtained immediately after birth in the newborn. The primary outcome was initial neonatal gentamicin serum concentration after birth. Several secondary outcomes were evaluated including nephrotoxicity and ototoxicity. A subgroup analysis comparing baseline demographics of mother-newborn dyads with birth neonatal serum concentrations of less than 2 mcg/mL versus 2 mcg/mL or greater was performed.

RESULTS
A total of 32 mother-newborn dyads were included. Newborns had a median gestational age of 39.4 weeks and median birth weight of 3.4 kg. The mean initial gentamicin serum concentration was elevated at 3.1 ± 1.9 mcg/mL among all newborns. The median maternal dose based on actual body weight in newborns with gentamicin serum concentrations less than 2 mcg/mL was 3.5 (IQR, 3.3–4.8) mg/kg versus 4.8 (IQR, 4.3–5.2) mg/kg in those that had serum concentrations of 2 mcg/mL or greater (p = 0.025). All newborn gentamicin serum concentrations were less than 2 mcg/mL for maternal doses given less than 1 hour prior to delivery (n = 8). There were no significant differences in nephrotoxicity or ototoxicity.

CONCLUSIONS
Peripartum once daily dosing of gentamicin administered between 1 to 12 hours of birth may lead to clinically significant serum concentrations in newborns.
SO,MCT,OO,FO-ILE Is Associated With Better Side Effect Profile Than SO-ILE in Critically Ill Children Receiving Parenteral Nutrition
Authors: Gupta Neha , Ali Cherise , Talathi Saurabh 
Published: August 2023

OBJECTIVES
This study aimed to evaluate the side effect profile of soybean oil lipid injectable emulsion ­(SO-ILE) and soybean oil, medium-chain triglyceride, olive oil, fish oil lipid injectable emulsion (SO,MCT,OO,FO-ILE) in critically ill children requiring parenteral nutrition (PN).

METHODS
This is an observational study of children admitted to our pediatric intensive care unit requiring PN for ≥7 days. Patients were divided into 2 cohorts: SO,MCT,OO,FO-ILE (n = 34) and SO-ILE (n = 111). Outcomes included development of hypertriglyceridemia (HTG), intestinal failure–associated liver disease (IFALD), length of stay, and mortality. Logistic regression was performed after controlling for duration and maximum dose of lipids.

RESULTS
The median maximum lipid dose was significantly higher in the SO,MCT,OO,FO-ILE cohort (2.7 vs 3 g/kg; p = 0.01). Prevalence of baseline HTG was similar in both cohorts. After excluding patients with baseline HTG, incidence of HTG upon PN introduction was higher in the SO-ILE cohort (51.2% vs 26.7%; p = 0.02). The SO-ILE cohort also had significantly higher triglyceride concentrations at peak and upon discontinuation of PN (p &lt; 0.05). Direct bilirubin and C-reactive protein were significantly higher in the SO-ILE cohort after stopping PN. Five patients (3.4%) developed IFALD, 4 of whom were in the SO-ILE cohort (p = 0.85). Upon logistic regression, mortality rate and incidence of HTG remained significantly higher in the SO-ILE cohort (adjusted odds ratio, 2.3 [95% CI, 1.1–5.3]; p = 0.04; and adjusted odds ratio, 2.0 [95% CI, 1.3–5.1]; p = 0.03, respectively).

CONCLUSIONS
In critically ill children requiring PN, SO-ILE was associated with a higher risk of HTG, ­elevated direct bilirubin, inflammatory markers and mortality compared with SO,MCT,OO,FO-ILE.
Evaluation of an Empiric Vancomycin Dosing Protocol on Goal Troughs and Acute Kidney Injury in a Neonatal Intensive Care Unit
Authors: Kenneally Allison M. , Leonhardt Kelsey R. , Schadler Aric , Garlitz Karen L. 
Published: August 2023

OBJECTIVE
Review the efficacy and safety of an updated empiric vancomycin dosing protocol in a neonatal intensive care unit (NICU).

METHODS
Retrospective chart review including neonates with postmenstrual age (PMA) less than 40 weeks without renal dysfunction who received vancomycin per protocol at a single institution’s NICU before and after implementation of an updated dosing protocol. The primary outcome is the proportion of initial therapeutic troughs. Secondary outcomes include average trough, achievement of a therapeutic trough, number of days before attainment of a therapeutic trough, and proportion of acute kidney injury (AKI) during therapy.

RESULTS
The 2 groups were similar in gestational age, race, birth weight, PMA, and weight at time of vancomycin initiation. The post-implementation group had a higher proportion of initial therapeutic troughs (33.0% vs 55.1%) and a lower proportion of a subtherapeutic (58.7% vs 43.8%) and supratherapeutic (8.3% vs 1.1%) initial troughs (p = 0.002). The median trough was not different (9.20 vs 10.50 mg/L; p = 0.092). There was no difference in the proportions of achieving a therapeutic trough throughout therapy (69% vs 76%; p = 0.235); however, the post-implementation group achieved a therapeutic trough 1 day earlier (3 vs 2 days; p &lt; 0.001). There was no difference in proportions of AKI developing between the pre-implementation vs post-implementation groups (10.1% vs 5.6%; p = 0.251).

CONCLUSIONS
Implementation of an updated vancomycin dosing protocol yielded a higher percentage of initial therapeutic vancomycin troughs and patients reached the therapeutic range 1 day earlier without increasing the proportion of AKI.
Gabapentin as Adjunctive Therapy in Neonatal Opioid Withdrawal Syndrome: A Case Series
Authors: Patz Caroline , Liviskie Caren , Bird Merielle , Zeller Brandy , Vesoulis Zachary A. , Smyser Christopher D. , McPherson Christopher 
Published: August 2023

OBJECTIVE
We describe a single center experience with gabapentin as adjunctive therapy in infants with neonatal opioid withdrawal syndrome (NOWS).

METHODS
We performed a retrospective chart review of infants receiving gabapentin for NOWS. Data points collected included patient’s sex, gestational age, maternal opioid exposure, NOWS medication dosing and length of therapy, number of failed wean attempts, time to successful morphine wean and duration of morphine wean, length of stay in the neonatal intensive care unit (NICU), and NOWS medications at discharge.

RESULTS
Six infants received gabapentin as adjunctive treatment for NOWS. All infants failed 2–4 morphine weans before initiation of gabapentin despite the addition of clonidine. All infants that received gabapentin were successfully weaned off morphine. The time to wean off morphine after gabapentin initiation varied from 4–35 days. Maximum gabapentin doses ranged from 15 – 42.7 mg/kg/day. Five infants were discharged from the NICU on gabapentin.

CONCLUSIONS
Gabapentin appeared to facilitate successful morphine weans in six patients with NOWS who were previously unable to wean despite the initiation of clonidine.
Relationship of platelet subgroups with prognosis and mortality in patients with mild, severe and critical COVID-19
Authors: ERGENÇ Zeynep , KAYA Gülsüm , KARACA OCAK Özlem , İNCE Özgür , GÜNAY Serkan , ERGENÇ Hasan 
Published: August 2023

Introduction: This study investigates whether platelet-related indicators including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), Plateletcrit (PCT), and platelet large cell ratio (P-LCR) could be effective biomarkers in the prognostic of 2019-novel coronavirus disease (COVID-19) fatality.
Methods: Out of 380 patients diagnosed with COVID-19, 98 patients were randomly and retrospectively were included in our study. Detection of COVID-19 was performed according to the World Health Organization (WHO) guidelines and using quantitative polymer chain reaction (qPCR). Clinical and laboratory data and medical records for all study participants were collected from a digital version of their health history at Ayancik State Hospital and Diyarbakır Gazi Yaşargil Training and Research Hospital. All patients were followed up daily until discharge or death and were eventually classified into three categories: Mild, severe, and critical patients. Data analysis was performed using SPSS-26 for Windows (Statistical Package for Social Science, SPSS Inc. Chicago IL, USA®Z), and a 95% confidence level was selected. P < 0.5 was considered statistically significant.
Results: Of participants, 64.3% of the patients are 65 years and older, 54.1% are male, 60.2% survived, 39.8 % died and 35.7% are in critical condition. The mortality rate is higher in males and 65 years and older. While PLT (190,24) and PCT (0,21) measurements were higher in surviving patients, MPV (10,67), PDW (16,15) and P-LCR (30,82) measurements were higher in deceased patients. PDW and PCT measurements are more effective in predicting mortality state according to Roc analysis. The measurement that best predicts the deceased status of patients who are positive according to the cut-off value determined is PDW (0.621), and the measurement that best estimates the surviving patients is PLT (0.925).
Conclusions: In our study, it was concluded that high MPV, PDW and P-LCR and low platelet values are associated with poor prognosis of COVID-19 disease, and PDW and PCT measurements are more effective in predicting mortality in patients with COVID-19 infection. Laboratory parameters such as MPV, PDW, P-LCR, PDW, and PCT can provide clinicians with predictions of prognosis and mortality from COVID-19 disease.
Existence results for nonlinear Schrodinger equations involving the fractional (p,q)-Laplacian and critical nonlinearities
Authors: Lv Huilin , Zheng Shenzhou , Feng Zhaosheng 
Published: August 2023

In this article, we consider the existence of ground state positive solutions for nonlinear Schrodinger equations of the fractional (p,q)-Laplacian with Rabinowitz potentials defined in \(R^n\), $$ ( -\Delta ) _p^{s_1}u+( -\Delta )_q^{s_2}u+V( \epsilon x) ( | u|^{p-2}u+| u| ^{q-2}u) =\lambda f( u) +\sigma | u| ^{q_{s_2}^{\ast }-2}u. $$ We prove existence by confining different ranges of the parameter \(\lambda\) under the subcritical or critical nonlinearities caused by \(\sigma=0\) or 1, respectively. In particular, a delicate calculation for the critical growth is provided so as to avoid the failure of a global Palais-Smale condition for the energy functional.
For more information see https://ejde.math.txstate.edu/Volumes/2021/100/abstr.html
Global well-posedness for Klein-Gordon-Hartree and fractional Hartree equations on modulation spaces
Authors: Bhimani Divyang G. 
Published: August 2023

We study the Cauchy problems for the Klein-Gordon (HNLKG), wave (HNLW), and Schrodinger (HNLS) equations with cubic convolution (of Hartree type) nonlinearity. Some global well-posedness and scattering are obtained for the (HNLKG) and (HNLS) with small Cauchy data in some modulation spaces. Global well-posedness for fractional Schrodinger (fNLSH) equation with Hartree type nonlinearity is obtained with Cauchy data in some modulation spaces. Local well-posedness for (HNLW), (fHNLS) and (HNLKG) with rough data in modulation spaces is shown. As a consequence, we get local and global well-posedness and scattering in larger than usual \(L^p\)-Sobolev spaces.
For more information see https://ejde.math.txstate.edu/Volumes/2021/101/abstr.html
Curvature blow-up for the periodic CH-mCH-Novikov equation
Authors: Zhu Min , Wang Ying , Chen Lei 
Published: August 2023

We study the CH-mCH-Novikov equation with cubic nonlinearity, which is derived byan asymptotic method from the classical shallow water theory. This model can be related to three different important shallow water equations: CH equation, mCH equation and Novikov equation. We show the curvature blow-up of the CH-mCH-Novikov equation by the method of characteristics and conserved quantities to the Riccati-type differential inequality.
For more information see https://ejde.math.txstate.edu/Volumes/2021/103/abstr.html
Singular Monge-Ampere equations over convex domains
Authors: Li Mengni 
Published: August 2023

In this article we are interested in the Dirichlet problem for a class of singular Monge-Ampere equations over convex domains being either bounded or unbounded. By constructing a family of sub-solutions, we prove the existence and global Holderestimates of convex solutions to the problem over convex domains. The global regularity provided essentially depends on the convexity of the domain.
For more information see https://ejde.math.txstate.edu/Volumes/2021/86/abstr.html
Solutions and eigenvalues of Laplace's equation on bounded open sets
Authors: Yang Guangchong , Lan Kunquan 
Published: August 2023

We obtain solutions for Laplace's and Poisson's equations on bounded open subsets of \(R^n\) (\(n\geq 2)\), via Hammerstein integral operators involving kernels and Green's functions, respectively. The new solutions are different from the previous ones obtained by the well-known Newtonian potential kernel and the Newtonian potential operator. Our results on eigenvalue problems of Laplace's equationare different from the previous results that use the Newtonian potential operator and require \(n\geq 3\). As a special case of the eigenvalue problems, we provide a result under an easily verifiable condition on the weight function when \(n\geq 3\). This result cannot be obtained by using the Newtonian potential operator.
For more information see https://ejde.math.txstate.edu/Volumes/2021/87/abstr.html
Coupled porosity-fluid concentration flux-temperature waves in isotropic porous media
Authors: Fama Alessio , Restuccia Liliana 
Published: August 2023

In this article, we study a problem on propagation of coupled porosity, fluid concentration flux, and temperature waves. We use a model formulated in previous papers for porous media saturated by a fluid flow, in the framework of non-equilibrium thermodynamics. We derive three modes of propagation in the one-dimensional and perfect isotropic case, and then we test the validity of the model. The waves propagation velocities are represented in diagrams as functions of the wave number. The derived results have applications in technological sectors such as seismology, medical sciences, geology and nanotechnology. For more information see https://ejde.math.txstate.edu/Volumes/2021/88/abstr.html
Logarithmically improved regularity criteria for the Navier-Stokes equations in homogeneous Besov spaces
Authors: Dao Nguyen Anh , Diaz Jesus Ildefonso 
Published: August 2023

We investigate a logarithmically improved regularity criteria in terms of the velocity, for the vorticity, for the Navier-Stokes equations in homogeneous Besov spaces. More precisely, we prove that if the weak solution u satisfies either $$\displaylines{ \int^T_0 \frac{\|u(t)\|^{\frac{2}{1-\alpha}}_{{\rm \dot{B}^{-\alpha}_{\infty, \infty}}}} {1+\log^+\|u(t)\|_{\dot{H}^{s_0}}} \, dt <\infty, \quad \text{or}\quad \int^T_0 \frac{\|w(t)\|_{\dot{B}^{-\alpha}_{\infty, \infty}}^\frac{2}{2-\alpha} } {1 + \log^ + \|w(t)\|_{\dot{H}^{s_0}}}\,dt<\infty\,, }$$ where w =rot u, then u is regular on (0,T].Our conclusions improve some results by Fan et al. [5].
For more information see https://ejde.math.txstate.edu/Volumes/2021/89/abstr.html
Asymptotic behavior of solutions to porous medium equations with boundary degeneracy
Authors: Hao Xutong , Zhou Mingjun , Jing Xinxin 
Published: August 2023

This article concerns the asymptotic behavior of solutions to a class of one-dimensional porous medium equations with boundary degeneracy on bounded and unbounded intervals. It is proved that the degree of degeneracy, the exponents of the nonlinear diffusion, and the nonlinear source affect the asymptotic behavior of solutions. It is shown that on a bounded interval, the problem admits both nontrivial global and blowing-up solutions if the degeneracy is not strong; while any nontrivial solution must blow up if the degeneracy is strong enough. For the problem on an unbounded interval, the blowing-up theorems of Fujita type are established. The critical Fujita exponent is finite if the degeneracy is not strong, while infinite if the degeneracy is strong enough. Furthermore, the critical case is proved to be the blowing-up case if it is finite.
For more information see https://ejde.math.txstate.edu/Volumes/2021/96/abstr.html
Sociodemographic Factors Associated With Oral Health-Related Quality Of Life Among Elderly Population
Authors: Mayasari Yufitri , Ruslan Mutiara Rina Rahmawati , Mersil Sarah , Hertiana Elin , Viraningtyas Tirani Bina 
Published: August 2023

The aim of the study was to analyze sociodemographic factors associated with oral health-related quality of life among elderly population. Methods: a cross-sectional study was undertaken in 20-23 February 2022 with 75 elderly people aged 60 years and older. This sample size was representative of the geriatric population living at home in the RW 02, Kelurahan Sukahati, Kecamatan Cibinong, Kabupaten Bogor. Participants were interviewed at home by trained interviewers using a 15-item questionnaire that included socio-demographic indicators (gender and age). Participants' OHRQoL were evaluated using a validated Indonesian version of GOHAI. The questionnaire consisted of 12 questions, with answers ranging from 1 to 5. GOHAI evaluates three aspects: (A) Physical functions such as speaking, eating and swallowing. (B) Dissatisfaction with appearance and psychosocial effects, including contact with others, self-esteem for oral health, and concerns about appearance. (C) Pain or discomfort, including taking medication to relieve pain. Results: a total of 75 participants completed the questionnaire. Most of the participants were between 60-69 years old (52%). The study population included 33 men (44%) and 42 women (56%). Most of the participants reported a poor OHRQoL score (GOHAI ? 56). There was significantly associated between age and gender with GOHAI category (p = 0.026, CI 95%; p = 0.000, CI 95%). Conclusion: most of respondents reported a poor oral health related quality of life. Sociodemographic factors (age and gender) associated with oral health related quality of life in elderly people.
Determination of the content of heavy metals in residues released from manufacturing procceses of Ni-Cd batteries by atomic absorption spectrometry
Authors: Aliu Milihate 
Published: August 2023

The residues discharged from industry contain a bulk amount of liquid and solid wastes with substantial quantities of toxic heavy metals. These wastes from the industries is not only polluting the water but also the sediment in the adjunct river and ultimately affecting the aquatic life. The objectiv of this study is to evaluate the heavy metal (i.e., Cd, Cu, Co, Fe, Pb, Mn, Ni and Zn) concentration in solid residue samples released from the manufacturing processes of Ni- Cd batteries. For this purpose samples were digested with aqua regia and analysed for metals by the atomic absorption spectrophotometer (AAS). This study revealed that the metal concentration for Cd, Cu, Co, Fe, Pb, Mn, Ni and Zn were found to be 4200-16500 mg/kg, 140-850 mg/kg, 100-629 mg/kg, 170-630 mg/kg, 150 -920 mg/kg, 30-250 mg/kg, 6400-35000 mg/kg and 110-800 mg/kg respectively. The concentration of heavy metals in residues samples decreased with the following order: Ni > Cd > Pb > Cu > Zn > Co > Fe > Mn. The results of this study provide support for the prevention of human health risks and the control of soil heavy metal pollution. In the industrial area, waste management is one of the difficult and most challenging issue. Sustainable solution is the best fit for dealing with the waste management, because when discharged on the land as well as dumped into the surface water, which ultimately lead to contamination due to accumulation of toxic metals and resultes in a series of problems in living beings, because they cannot be completely degraded.
Enhancing the water quality of treated effluents from Wastewater Treatment Plants by mitigating emerging pollutants
Authors: OUASFI Nadia , SABBAR El mouloudi , KHAMLICHE Layachi 
Published: August 2023

With the increasing demand for water resources and growing environmental concerns, reclaimed water from wastewater treatment plants has gained prominence as an alternative water source for various non-potable applications. However, one of the major challenges in utilizing reclaimed water is the presence of emerging pollutants, which encompass a wide range of chemical and biological compounds not routinely monitored or regulated in conventional wastewater treatment processes.
This study aims to address the pressing issue of emerging pollutants in reclaimed water by exploring and evaluating innovative strategies for their removal.
Through a comprehensive literature review, cutting-edge technologies and advanced treatment methods will be assessed, focusing on their efficiency in eliminating a spectrum of emerging pollutants from treated effluents.
Moreover, this research seeks to shed light on the potential risks associated with these emerging contaminants and their impact on human health and the environment.
Ultimately, the finding from this study will contribute to the development of sustainable and effective approaches for enhancing the water quality of reclaimed water from wastewater treatment plants.by mitigating the presence of emerging pollutants, stakeholders can confidently promote the safe and reliable use of reclaimed water, thus fostering a more resilient and environmentally conscious water management paradigm.
The Chlorophyll-a Content Distribution in the Atlantic Ocean in December 2019 — January 2020 according to Ship Measurements at the Different Hydrometeorological Conditions
Authors: Shtraikhert E. A. , Zakharkov S. P. , Salyuk P. A. , Ponomarev V. I. , Artemiev V. A. , Glukhovets D. I. , Latushkin A. A. 
Published: August 2023

The horizontal and vertical chlorophyll-a concentrations (Chl) distributions along the ship route of 79th cruise of R/V “Akademik Mstislav Keldysh” in the Atlantic Ocean in December 2019—January 2020 were obtained. Analysis of the observations was conducted for the biogeochemical provinces which were determined by means of the different hydrometeorological conditions for the phytoplankton community functioning.Three methods of Chl measurements were applied: standard extraction method of the seawater samples, the fluorometer underway measurements in the flow-through water system at the depth of 5 m and in-situ profiling fluorometer measurements at stations. Also, measurements of the seawater temperature and salinity in the flow-through water system, the CTD and optical profiling, and ARGO floats were used.The maximum Chl values in the near-surface ocean layer are observed at zones of divergence in the Canary upwelling systems (CNRY) (1.3 mg/m3) and in the Falkland (Malvinas) Current system (4.8 mg/m3), and also in the Drake Strait (1.2 mg/m3). The least Chl values (0.01–0.12 mg/m3) are observed in the tropical, equatorial areas and in the South Atlantic Subtropical Anticyclonic Gyre (SASTG) at the ship route.Vertical Chl profiles with absence of the significant Chl maximum were found. In the CNRY region the Chl values were not changed much within the euphotic zone. While in the region of the Antarctic Circumpolar Current in the Drake Strait and in the offshore stream of the Falkland Current the quasi-homogeneous Chl profiles were observed in the upper layer which is almost 2 times deeper than the euphotic zone.In the profiles with the significant local Chl maximum the most Chl value of 3.5 mg/m3 is observed at the depth about 12 m in the upwelling region on the Patagonian Shelf. In other regions the depth of Chl maximum localization (0.2–0.9 mg/m3) varies widely from 25 to 120 m. In the western part of the SASTG region the absolute Chl maxima were found at the depth of 120 m, that is deeper, then the euphotic zone which is equal to 100 m.