bluuebunny/crossref_metadata_2025_split huggingface dataset:
No evidence of resistance to itraconazole in a prospective real-world trial of dermatomycosis in India
Authors: Handa S. , Villasis-Keever A. , Shenoy M. , Anandan S. , Bhrushundi M. , Garodia N. , Fife D. , De Doncker P. , Shalayda K. , Hu P. , Fonseca S. , Cure-bolt N. 
Published: February 2023

BackgroundThe prevalence of superficial fungal infections in India is believed to have increased substantially in the past decade. We evaluated the treatment outcomes and risk factors associated with clinical response to a treatment course of itraconazole for the management of dermatomycosis in India.MethodsIn this real-world, prospective pilot study (August 2019 to March 2020), adult participants (18–60 years), diagnosed withT.crurisorT.corporis, received itraconazole 200 mg/day (any formulation) orally for 7 days, and were followed for an additional 7 days.ResultsThe study was terminated early due to the COVID-19 pandemic. Of 40 enrolled participants (mean [SD] age, 35.5 [12.73] years; {62.5%}] male; 37 received itraconazole and 20 (50%) completed the study. The median (range) Clinical Evaluation Tool Signs and Symptoms total score at baseline was 5.5 (2–10). Clinical response of “healed” or “markedly improved” based on the Investigator Global Evaluation Tool at day 7 (primary objective) was 42.9% (12/28; 95% CI: 24.53%, 61.19%). Itraconazole minimum inhibitory concentration for identified microorganisms,T.mentagrophytesspecies complex (91.7%) andT.rubrum(8.3%), was within the susceptibility range (0.015–0.25 mcg/mL). At day 14, 8/13 (61.5%) participants achieved a mycological response, 2/13 participants (15.4%) had a mycological failure and 90% showed a clinical response.ConclusionCOVID-19 pandemic affected patient recruitment and follow-up, so the findings call for a careful interpretation. Nevertheless, this real-world study reconfirmed the clinical efficacy and microbial susceptibility to itraconazole for the fungi causing dermatophytosis in India.Trial registrationTrial registration number: Clinicaltrials.govNCT03923010.
Compte rendu de Alexis Drahos : «L’astronomie dans l’art de la Renaissance à nos jours»
Authors: Stoffel Jean-François 
Published: February 2023

Drahos (Alexis), L’astronomie dans l’art de la Renaissance à nos jours. – Paris : Éditions Citadelles & Mazenod, 2014. – 183 p. – 1 vol. relié de 28 × 24 cm. – 59,00 €. – isbn 9782-85088-605-8.
Compte rendu de Michel Blay : «Critique de l’histoire des sciences»
Authors: Verdet Cyril 
Published: February 2023

Blay (Michel), Critique de l’histoire des sciences. – Paris : CNRS éditions, 2017. – 301 p. – 1 vol. broché de 14 × 20,5 cm. – 22,00 €. – isbn 978-2-271-09184-0.
«Les saints ont la parole»
Authors: Polet Caroline , Beauthier Jean-Pol , Lefèvre Philippe , George Philippe 
Published: February 2023

Depuis la fin du XXe siècle, les autorités ecclésiastiques autorisent, voire encouragent, l’analyse scientifique des reliquaires et de leurs contenus. Ces analyses sont réalisées par des experts regroupant un ensemble de domaines de recherche : historiens, anthropologues, médecins légistes, archéologues, spécialistes des datations, des métaux, des textiles, etc. À travers de nombreux exemples dans lesquels nous développerons principalement les résultats de l’analyse des restes humains, nous verrons que ces études pluridisciplinaires ont livré des données parfois surprenantes.
* * *
Since the late 20th century, ecclesiastical authorities have authorised, and even encouraged, the scientific analysis of reliquaries and their contents. These analyses are performed by experts from a wide range of research fields: historians, anthropologists, forensic scientists and archaeologists, as well as specialists in chronological dating, metals, textiles, etc. We will demonstrate, by means of numerous examples focussing mainly on the analysis of human remains, that these multidisciplinary studies can yield some startling results.
«Archives Georges Lemaître» en mode 2.0
Authors: Fillieux Véronique , Derauw Caroline , François Aurore , Picron Delphine 
Published: February 2023

Les « Archives Georges Lemaître » constituent une des premières réalisations du portail UCLArchives élaboré et mis en place afin de faire connaître et de valoriser, auprès des chercheurs et du grand public, certains fonds patrimoniaux des archives de l’UCLouvain. Cette plate-forme permet en effet de consulter en mode 2.0 certains documents du Fonds Lemaître, mais aussi de découvrir le scientifique au moyen de ressources documentaires organisées en expositions virtuelles. Après une brève présentation de Georges Lemaître et de ses archives, c’est le projet même du portail, de sa conception à sa réalisation, qui est exposé avec une mise en évidence de quelques pièces d’archives révélatrices tant de la richesse des fonds conservés que de la structure interne du site et de ses potentialités.
* * *
The “Georges Lemaître Archives” is one of the early achievements of the UCLArchives portal, which was developed and set up in order to publicise and promote, to both researchers and the general public, certain heritage collections of the UCLouvain archives. This platform allows one not only to consult, in version 2.0, certain documents of the Lemaître Collection, but also to discover the scientist through various resource materials laid out in the form of virtual exhibitions. After a brief presentation of Georges Lemaître and his archives, it is the very portal project itself that is exhibited, from its design to its completion, highlighting various archive materials which display both the richness of the preserved collection, as well as the internal structure of the site and its potential.
Définir le vivant et modéliser sa singularité
Authors: Modera Astrid 
Published: February 2023

Analyse critique de :
Lechermeier (Gilbert), Le vivant : la singularité et l’universel / préface de Michel Morange ; postface de Thomas Heams. – Paris : Éditions Matériologiques, 2019. – 370 p. – (Collection sciences & philosophie). – 1 vol. broché de 16,5 × 24 cm. – 26,00 €. – isbn 978-2-37361-204-2.
1937
Authors: Dubois Eve-Aline 
Published: February 2023

En 1937, Dirac propose son hypothèse des grands nombres. À partir de l’étude qu’il fait des constantes de la physique, il bâtit un modèle cosmologique en suivant une approche déductive. Ce faisant, il rejoint une tendance initiée par Eddington et suivie par d’autres. Cette nouvelle méthode interpelle Dingle, qui prend position en faveur de l’induction, en opposition à la déduction. Suite à diverses publications, un débat cosmologique et épistémologique prend place dans les pages de la revue Nature. Le présent article propose une revue commentée de cette année particulière, via l’analyse chronologique de diverses contributions. On découvre alors les balbutiements cosmologiques de l’hypothèse des grands nombres, mais on met aussi en lumière l’importante controverse épistémologique qui s’en suivit.
* * *
Dirac put forward his Large Numbers hypothesis (LNh) in 1937. Based on his study of physical constants, he built a cosmological model by following a deductive approach. In adhering to this method, he thus joined a trend that had been set in motion by Eddington. This new method countered that of Dingle, who had opted in favour of the opposing camp, namely induction. Numerous publications on this subject sparked a cosmological and epistemological debate within the journal Nature. By analysing various contributions in chronological order, the present article offers a commentary on this noteworthy year. The hesitant cosmological beginnings of the LNh are thereby brought to light, as is the major epistemological controversy that ensued.
À propos du lien entre la théorie quantique et les probabilités
Authors: Marchildon Louis 
Published: February 2023

La théorie des probabilités et la théorie quantique, l’une mathématique et l’autre physique, s’apparentent dans la mesure où chacune admet plusieurs interprétations fort différentes. Certains ont proposé que les problèmes conceptuels de la théorie quantique puissent être, sinon résolus, du moins atténués par une interprétation adéquate des probabilités. Nous montrerons plutôt, à travers un survol historique et analytique des probabilités et de la théorie quantique, que si certaines interprétations de l’une et de l’autre s’agencent particulièrement bien, aucune ne s’impose de façon unique.
* * *
The theory of probability and the quantum theory, the one mathematical and the other physical, are related in that each admits a number of very different interpretations. It has been proposed that the conceptual problems of the quantum theory could be, if not resolved, at least mitigated by a proper interpretation of probabilities. We rather show, through a historical and analytical overview of probabilities and quantum theory, that if some interpretations of the one and the other go along particularly well, none follows in a unique way.
L’empreinte de Kepler en astronomie contemporaine
Authors: Roy Jean-René 
Published: February 2023

Le 27 décembre 2021 marque le 450e anniversaire de la naissance de Johannes Kepler (1571-1630). Si Nicolas Copernic et Galileo Galilei sont le plus souvent présentés comme les phares de la révolution astronomique, Kepler est malheureusement parfois perçu comme un acteur secondaire dont le rôle et le travail auraient seulement servi de fondement à Isaac Newton (1643-1727) dans l’élaboration de sa théorie de la gravitation universelle. Newton a été l’héritier génial de Kepler en intégrant magistralement et naturellement la nouvelle mécanique céleste de ce dernier dans sa théorie de la gravitation. Considérant où Kepler se situe historiquement, il mérite d’être élevé au panthéon des géants qui ont transformé notre vision de l’univers et établi les fondements de la science contemporaine. Après un bref rappel de son œuvre, je montre que la pensée et la méthode de Kepler persistent profitablement dans l’astronomie d’aujourd’hui.
* * *
The 27th of December 2021 marks the 450th anniversary of the birth of Johannes Kepler (1571-1630). While Nicolaus Copernicus and Galileo Galilei are most often portrayed as beacons of the astronomical revolution, Kepler is sadly sometimes perceived as having played a minor role, his work having merely served to lay the groundwork for Isaac Newton’s (1643-1727) theory of universal gravitation. Newton was indeed a brilliant beneficiary of Kepler’s work, masterfully and naturally integrating the latter’s new celestial mechanics into his theory of gravitation. Considering the prominent place that Kepler occupies in history, one could argue that he deserves to be elevated to a position of utmost importance in the Astronomical Hall of Fame in terms of his contributions towards transforming our view of the universe and laying the foundations for contemporary science. Following a brief review of his work, I endeavour to demonstrate how Kepler’s thinking and methodology still exert a strong influence on contemporary astronomy.
«L’origine chrétienne de la science moderne»
Authors: Stoffel Jean-François 
Published: February 2023

Récemment savamment rééditée, la contribution qu’Alexandre Kojève offrit à Alexandre Koyré pour son septantième anniversaire s’attache à soutenir, de manière « beaucoup moins canularesque qu’elle ne paraît l’être à première vue », une affirmation que les « procédures historiennes » ne permettraient pas d’énoncer : si les Grecs n’ont pas développé la physique mathématique alors que les savants du XVIe siècle, au premier rang desquels Nicolas Copernic, ont réussi à la faire émerger, c’est parce que les premiers étaient païens alors que les seconds étaient spécifiquement chrétiens ! Seuls ces derniers, grâce au dogme de l’Incarnation, ont en effet été aptes à réussir l’universalisation de l’approche mathématique du monde. N’hésitant pas à lire cette contribution tel qu’il s’avère qu’elle a été lue, c’est-à-dire indépendamment de l’œuvre kojévienne et de sa mise en œuvre d’une « histoire raisonnée », cet article analyse les deux principales sources d’inspiration de ladite thèse, à savoir Pierre Duhem et Alexandre Koyré ; retrace la réception historique de cette contribution ; relève toutes les objections qui, à cette occasion, lui furent adressées ; et, finalement, formule quelques objections supplémentaires. Les lecteurs qui souhaiteront bénéficier de la réédition de ce texte kojévien pour le moins provocateur devraient ainsi être à même de déterminer le degré de crédibilité qu’il convient de lui accorder.
* * *
Having recently been expertly republished, the contribution that Alexandre Kojève offered to Alexandre Koyré for his seventieth birthday served to support, in a manner that was in fact “much less playful than it initially appeared to be”, a claim that “historical procedures” had suppressed: if the Greeks failed to develop mathematical physics where the scholars of the 16th century, the foremost of whom being Nicolas Copernicus, succeeded, then it must be due to the fact that the former were pagans while the latter were specifically Christian! Only the latter, by virtue of the doctrine of Incarnation, were deemed capable of achieving the universalisation of the mathematical approach to the world. Focussed on interpreting this contribution as it was intended to be read, in other words independently of Kojève’s work and its implementation of a “rational history”, this article endeavours to: analyse the two main sources of inspiration for the aforementioned theory, namely Pierre Duhem and Alexandre Koyré; trace the historical reception of this contribution; highlight all of the objections that it was subject to at the time; and, lastly, formulate a few additional objections. Those readers wishing to make the most of the reissue of this rather provocative Kojèvian text should thus be in a position to determine the degree of credibility that it should be afforded.
Georges Lemaître
Authors: Lambert Dominique 
Published: February 2023

Analyse critique de :
Lemaître (Georges), Learning the Physics of Einstein with Georges Lemaître : Before the Big Bang Theory / editors : Jan Govaerts and Jean-François Stoffel ; translated by Christine Leroy and Stephen Lyle. – Cham : Springer International Publishing, 2019. – xiv, 257 p. – 1 vol. relié de 16 × 24 cm. – 84,79 €. – isbn 978-3-030-22029-7.
Lemaître (Georges), L’ipotesi dell’atomo primitivo : saggio di cosmogonia / traduzione e introduzione di Mauro Stenico. – Trento : Fondazione museo storico del Trentino, 2019. – 243 p. – (Passati Presenti, 5). – 1 vol. broché de 11,5 × 19,5 cm. – 15,00 €. – isbn 978-88-7197-249-7.
Lemaître (Georges), La naissance du big bang. – Québec : PUL, 2020. – 261 p. – (Réminiscences). – 1 vol. broché de 11 × 18 cm. – 15,95 $. – isbn 978-2-7637-4839-9.
Bergson Lendja Ngemzue (Ange), La question cosmologique : Platon, Lemaître et l’origine de l’Univers / préface de Luc Brisson. – Paris : L’Harmattan, 2021. – 243 p. – (Ouverture philosophique, série Bibliothèque). – 1 vol. broché de 16 × 24 cm. – 26,00 €. – isbn 978-2-343-22473-2.
Soude et critique des fondements de la physique
Authors: Mawhin Jean 
Published: February 2023

Analyse critique de :
Lambert (Franklin) - Berends (Frits), Vous avez dit : sabbat de sorcières ? La singulière histoire des premiers Conseils Solvay / préface de Thibault Damour. – Les Ulis : edp sciences, 2019. – 322 p. – (Sciences & histoire). – 1 vol. broché de 16,5 × 24 cm. – 34,00 €. – isbn 978-2-7598-2371-0.
Libres propos inspirés par une biographie d’Alexandre Koyré
Authors: Iommi Amunátegui Godofredo 
Published: February 2023

Analyse critique de :
Zambelli (Paola), Alexandre Koyré, un juif errant ? / traduit par Irène Imbart. – Florence : Museo Galileo, 2021. – xv, 241 p. – (version électronique).
Elevación de SPINK2 en leucemia mieloide aguda
Authors: Gezer Sümbül , Emrence Zeliha , Elverdi Tuğrul , Ar Muhlis Cem , Salman Yaylaz Burcu , Paçal Ferda , Ünüvar Ayşegül , Sarıman Melda , Eşkazan Ahmet Emre , Karaman Serap , Salihoğlu Ayşe , Karakaş Zeynep , Abacı Neslihan , Sırma-Ekmekci Sema 
Published: February 2023

Resumen

Objectivos
La leucemia mieloide aguda (AML, por sus siglas en inglés) es una enfermedad muy heterogénea. Aunque se puede clasificar a los pacientes en grupos de riesgo según sus mutaciones genéticas, el pronóstico dentro de cada categoría varía sustancialmente. Es perentorio identificar nuevos marcadores moleculares de la AML. Recientemente, se ha descrito la elevación del inhibidor de la serina peptidasa Kazal tipo 2 (SPINK2) en la AML, habiendo sido relacionada con peores resultados clínicos en metaanálisis, así como en un número limitado de pacientes con AML.

Métodos
Analizamos la expresión de SPINK2 en 62 pacientes (45 adultos y 17 niños) con AML y en 11 líneas celulares mediante PCR cuantitativa (qRT-PCR). Los niveles de la proteína SPINK2 se determinaron en líneas celulares mediante ELISA.

Resultados
Observamos un aumento de expresión del ARNm de SPINK2 y de los niveles de la proteína en las líneas celulares de AML (HL60 y NB4), frente a otras líneas celulares (K562, Jurkat y NALM6, MCF7, HeLa, HUVEC, hFOB, 293T, U87). Los pacientes con AML mostraron una expresión elevada de ARNm de SPINK2 frente a los controles (p=0,004) y esta fue significativamente menor en los pacientes t(8;21) positivos, frente a los pacientes negativos (p=0,0006).

Conclusions
Estos resultados sugieren que el gen SPINK2 tiene un papel relevante en el desarrollo de la AML. Son necesarios más estudios para evaluar la expresión de SPINK2 en los pacientes con AML con la mutación t(8.21) e investigar su valor pronóstico en varios subgrupos de pacientes con AML.
A low-energy ion spectrometer with large field of view and wide energy range onboard a Chinese GEO satellite
Authors: Shan Xu , Miao Bin , Cao Zhe , Sun Zhenyu , Li Yiren , Liu Kai , Qu Sanbiao , Guo Xingyu , Su Zhenpeng , Shen Chenglong , Pan Zonghao , Li Xin , Hao Xinjun , Yang Xiaoping , Tian Chao , Jiang Yu , Liu Shubin , An Qi , Chen Xiangjun , Wang Yuming 
Published: February 2023

Abstract
A low-energy ion spectrometer (LEIS), onboard a Chinese navigation satellite in geosynchronous orbit, is one of the primary instruments for plasma detection. The LEIS is implemented by combining a top-hat electrostatic analyzer with a pair of angular scanning deflectors, which enables us to achieve in situ measurement of energetic ions in three-dimensional (3D) space with a large field of view of 360° × 90° and a wide energy range from 50 eV to 25 keV per charge. The key performance parameters including analyzer constant, geometric factor, linear relation function between elevation angles and deflector voltages, and the energy or angular resolutions have been determined by using detailed simulations and calibration experiments on the ground. The preliminary results from on-orbit observations demonstrate that the capability of the present LEIS payload can well meet the mission requirements for sampling the low-energy ion distributions in 3D space, measuring the negative satellite surface potential, and monitoring the magnetospheric storm or substorm activities.
The Vanishing Incumbency Advantage in State House Elections
Authors: Rogers Steven 
Published: February 2023

AbstractNinety-six percent of state legislative incumbents who appeared on the November 2022 ballot reclaimed their seats in the state legislature, the highest percentage since at least the 2010 elections. Such electoral success would suggest that these state legislators enjoyed a healthy incumbency advantage. However, prior work (e.g. Jacobson, G. C. 2015. “It’s Nothing Personal: The Decline of the Incumbency Advantage in US House Elections.”The Journal of Politics77 (3): 861–73.) indicates that the incumbency advantage has diminished in recent elections, at least in the US House. I find similar – but smaller – declines in the magnitude of the incumbency advantage in state house elections in the last two decades. Instead of being attributable to the traditional incumbency advantage, state legislative incumbents’ success in the 2022 elections is more likely a consequence of the increasing number of partisan state house districts and the continued nationalization of state politics.
Advanced tools and methods for treewidth-based problem solving
Authors: Hecher Markus 
Published: February 2023

Abstract
Computer programs, so-called solvers, for solving the well-known Boolean satisfiability problem (Sat) have been improving for decades. Among the reasons, why these solvers are so fast, is the implicit usage of the formula’s structural properties during solving. One of such structural indicators is the so-called treewidth, which tries to measure how close a formula instance is to being easy (tree-like). This work focuses on logic-based problems and treewidth-based methods and tools for solving them. Many of these problems are also relevant for knowledge representation and reasoning (KR) as well as artificial intelligence (AI) in general. We present a new type of problem reduction, which is referred to by decomposition-guided (DG). This reduction type forms the basis to solve a problem for quantified Boolean formulas (QBFs) of bounded treewidth that has been open since 2004. The solution of this problem then gives rise to a new methodology for proving precise lower bounds for a range of further formalisms in logic, KR, and AI. Despite the established lower bounds, we implement an algorithm for solving extensions of Sat efficiently, by directly using treewidth. Our implementation is based on finding abstractions of instances, which are then incrementally refined in the process. Thereby, our observations confirm that treewidth is an important measure that should be considered in the design of modern solvers.
Plasmonic metafiber for all-fiber Q-switched cylindrical vector lasers
Authors: Hua He , Zeng Chao , He Zhiwen , Lu Hua , Du Yueqing , Mao Dong , Zhao Jianlin 
Published: February 2023

Abstract
Metafibers, by integrating metasurface at the optical fiber tip, are emerging as the significant optical coupling platforms for nanophotonics and fiber-optic communities. Here, we propose a plasmonic metafiber for converting the fundamental mode to first-order mode in fiber, and as proof of device performance, demonstrate an all-fiber Q-switched cylindrical vector laser using the metafiber. Based on polarization-dependent plasmonic resonance, a polarization-independent mode conversion metasurface is designed theoretically and numerically, fabricated directly on fiber facet, and packaged as an all-fiber component with efficiency up to 21% at 1550-nm band. Using the metafiber in an all-fiber laser, Q-switched azimuthally polarized beam (APB) and radially polarized beam (RPB) are delivered at wavelength of 1548.5 nm with pulse durations from ∼7 to ∼2 μs when pump power increases from 30 to 120 mW. The mode purities of the APB and RPB are 86.5% and 90.7%, respectively. This work outlines a new strategy to integrate metasurfaces into “all-in-fiber” systems and offers a reliable route to construct next-generation laser sources, such as all-fiber ultrafast structured lasers.