bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daratumumab plus bortezomib, cyclophosphamide, and dexamethasone in Asian patients with newly diagnosed AL amyloidosis: subgroup analysis of ANDROMEDA
Authors: Suzuki Kenshi , Wechalekar Ashutosh D. , Kim Kihyun , Shimazaki Chihiro , Kim Jin Seok , Ikezoe Takayuki , Min Chang-Ki , Zhou Fude , Cai Zhen , Chen Xiaonong , Iida Shinsuke , Katoh Nagaaki , Fujisaki Tomoaki , Shin Ho-Jin , Tran NamPhuong , Qin Xiang , Vasey Sandra Y. , Tromp Brenda , Weiss Brendan M. , Comenzo Raymond L. , Kastritis Efstathios , Lu Jin 
Published: March 2023

Abstract
Subcutaneous daratumumab plus bortezomib/cyclophosphamide/dexamethasone (VCd; D-VCd) improved outcomes versus VCd for patients with newly diagnosed immunoglobulin light-chain (AL) amyloidosis in the phase 3 ANDROMEDA study. We report a subgroup analysis of Asian patients (Japan; Korea; China) from ANDROMEDA. Among 388 randomized patients, 60 were Asian (D-VCd, n = 29; VCd, n = 31). At a median follow-up of 11.4 months, the overall hematologic complete response rate was higher for D-VCd versus VCd (58.6% vs. 9.7%; odds ratio, 13.2; 95% confidence interval [CI], 3.3–53.7; P < 0.0001). Six-month cardiac and renal response rates were higher with D-VCd versus VCd (cardiac, 46.7% vs. 4.8%; P = 0.0036; renal, 57.1% vs. 37.5%; P = 0.4684). Major organ deterioration progression-free survival (MOD-PFS) and major organ deterioration event-free survival (MOD-EFS) were improved with D-VCd versus VCd (MOD-PFS: hazard ratio [HR], 0.21; 95% CI, 0.06–0.75; P = 0.0079; MOD-EFS: HR, 0.16; 95% CI, 0.05–0.54; P = 0.0007). Twelve deaths occurred (D-VCd, n = 3; VCd, n = 9). Twenty-two patients had baseline serologies indicating prior hepatitis B virus (HBV) exposure; no patient experienced HBV reactivation. Although grade 3/4 cytopenia rates were higher than in the global safety population, the safety profile of D-VCd in Asian patients was generally consistent with the global study population, regardless of body weight. These results support D-VCd use in Asian patients with newly diagnosed AL amyloidosis. ClinicalTrials.gov Identifier: NCT03201965.
Broadband circular dichroism in chiral plasmonic woodpiles
Authors: Abdennadher Bilel , Iseli René , Steiner Ullrich , Saba Matthias 
Published: March 2023

AbstractThe circular dichroism (CD) of a material is the difference in optical absorption under left- and right-circularly polarized illumination. It is crucial for a number of applications, from molecular sensing to the design of circularly polarized thermal light sources. The CD in natural materials is typically weak, leading to the exploitation of artificial chiral materials. Layered chiral woodpile structures are well known to boost chiro-optical effects when realized as a photonic crystal or an optical metamaterial. We here demonstrate that light scattering at a chiral plasmonic woodpile, which is structured on the order of the wavelength of the light, can be well understood by considering the fundamental evanescent Floquet states within the structure. In particular, we report a broadband circular polarization bandgap in the complex band structure of various plasmonic woodpiles that spans the optical transparency window of the atmosphere between 3 and 4 $$\upmu$$
μ
m and leads to an average CD of up to 90% within this spectral range. Our findings could pave the way for an ultra-broadband circularly polarized thermal source.
Ultrasound-guided SoracteLite™ transperineal laser ablation (TPLA) of the prostate for the treatment of symptomatic benign prostatic hyperplasia (BPH): a prospective single-center experience
Authors: Laganà Antonino , Di Lascio Giovanni , Di Blasi Aldo , Licari Leslie Claire , Tufano Antonio , Flammia Rocco Simone , De Carolis Andrea 
Published: March 2023

Abstract
Purpose
To evaluate the efficacy and safety of ultrasound-guided transperineal laser ablation (TPLA) in patients with symptomatic BPH.

Materials and methods
From January 2020 to January 2022, 63 prospectively enrolled patients underwent TPLA with a 1064-nm continuous-wave diode laser (EchoLaser, Elesta SpA). Primary endpoints were the change in IPSS, QoL, Qmax, PVR and prostate volume at 3 and 12 months.

Results
At 3 months, IPSS improved from 20.8 ± 7.4 to 11.0 ± 6.6 (p < 0.001), QoL from 4.7 ± 1.4 to 1.5 ± 1.2 (p < 0.001) and Qmax from 8.6 ± 3.5 mL/s to 13.2 ± 5.7 mL/s (p = 0.083). PVR decreased from 124.8 ± 115.4 mL to 43.6 ± 53.6 mL (p < 0.001), and prostate volume decreased from 63.6 ± 29.7 mL to 45.6 ± 21.8 mL (p = 0.003). At 12 months, IPSS improved from 20.8 ± 7.4 to 8.4 ± 5.9 (p < 0.001), QoL from 4.7 ± 1.4 to 1.2 ± 0.8 (p < 0.001), and Qmax from 8.6 ± 3.5 mL/s to 16.2 ± 4.3 mL/s (p = 0.014). PVR decreased from 124.8 ± 115.4 mL to 40.6 ± 53.6 mL (p = 0.003), and prostate volume decreased from 63.6 ± 29.7 mL to 42.8 ± 14.2 mL (p = 0.071). Transient complications consisted of two patients with prostatic abscess (Clavien-Dindo grade IIIa) and one patient with orchitis (Clavien-Dindo grade II).

Conclusions
TPLA for symptomatic BPH provides clinical benefits at 3 and 12 months, and the treatment is well tolerated.
Future changes of circulation types and their effects on surface air temperature and precipitation in the SMHI large ensemble
Authors: Hansen Felicitas , Belušić Danijel , Wyser Klaus , Koenigk Torben 
Published: March 2023

AbstractBeing strongly influenced by internal climate variability, the atmospheric circulation response to greenhouse gas forcing in the future climate is uncertain. This study addresses atmospheric circulation through representative circulation types (CTs) and investigates the CTs’ changes with respect to frequency and effect on surface temperature and precipitation over a pan-Scandinavian domain. The analysis is based on the Swedish Meteorological and Hydrological Institute Large Ensemble performed with EC-Earth3: 50-member ensembles from one historical and six scenario simulations for the twenty-first century are used to assess internal variability and significance of changes. Although the results show no strong future changes in the CTs’ sea level pressure patterns, CT frequency changes suggest a future extension of summer conditions towards spring and autumn and point towards a clearer distinction between summer and winter. The present-climate CT effect on surface temperature is found to generally weaken which is consistent with a general decrease in temperature variability. Largest-scale and strongest temperature effect changes are projected between March and May for CT3, a cyclone towards the east of the domain associated with a domain-wide cooling effect that will likely be decreased towards the end of the twenty-first century. Similarly but of opposite sign, the CT effect on precipitation is strengthening as a result of the increased precipitation variability. Here, largest-scale and strongest effect enhancement is found for CT6, thus increasing its wetting effect over southern Scandinavia and drying effect west of the Scandes. Changes are generally largest towards the end of the twenty-first century and tend to increase with the forcing strength, thus maximizing for SSP585.
Light and scanning electron microscope observations of the digenean intestinal parasite Acanthostomum spiniceps Looss 1896 (Cryptogonimidae) from the catfish Bagrus bajad and B. docmak
Authors: Allam Hend E. , Mashaly Mohamed I. , EL-Naggar Mohamed M. 
Published: March 2023

Abstract
Fishes of the River Nile are a promising source of animal protein. The catfishes Bagrus bajad Fabricius 1775 and Bagrus docmak Fabricius 1775 are economically important with well-marketable size and use in fish farming. Digenean parasites cause severe damage to the gut tissue of their fish hosts. There are still some questions regarding the taxonomical features of the genus Acanthostomum Looss 1899. The present study has revealed new morphological features that confirmed the identity of the collected worms as Acanthostomum spiniceps Looss 1896 and aided in elucidating the possible functions of different internal organs and surface features. A long-stemmed excretory bladder was detected but there was no evidence of gonotyl. The circumoral spines (28–30) were detected in the early juvenile stage and adult. The ventral sucker has no tegumental folds in juveniles or crescent-shaped tegumental folds in adults but possesses two overlapping lips. In both juveniles and adults, the oral sucker with the associated circumoral spines assumed retracted, and protracted positions reflecting its highest movement activity. Elongation of the anterior region and partial emergence of the oral cavity in living juveniles and adults were described. The possible functions of the forebody glands and the posterior body openings near the anal pores were discussed. Large, non-ciliated, dome-shaped, and small ciliated, button-like papillae were concentrated on the body surface, particularly the oral and ventral suckers. The tegument possesses densely arranged single-pointed and scale-like spines that gradually decrease in size and number as they proceed posteriorly.
Reproductive compensatory photosynthesis in a semi-arid rangeland bunchgrass
Authors: Hamerlynck Erik P. , O’Connor Rory C. , Copeland Stella M. 
Published: March 2023

AbstractWhile increased foliar photosynthesis is well documented across many plant species in response to diverse modes of herbivory, the compensatory ability of photosynthetically active reproductive structures is unknown. To address this, we partially defoliated basal florets in seed heads of crested wheatgrass (Agropyron cristatum (L.) Gaertn.), an exotic Eurasian perennial bunchgrass widely distributed across North American sagebrush steppe. We followed direct and indirect responses by tracking post-clipping photosynthesis in clipped basal and unclipped distal florets, respectively, and comparing these to similar florets on unclipped seed heads. Compensatory photosynthesis was apparent 24 h after clipping; over the pre-anthesis period, clipped basal floret photosynthesis was + 62%, stomatal conductance was + 82%, and PSII photochemical yield was − 39% of unclipped controls. After anthesis, intact florets distal to clipped florets had modestly higher photosynthetic rates compared to controls, while basal floret rates did not differ between treatments. Compensatory photosynthesis reduced intrinsic water use efficiency (iWUE; photosynthesis/stomatal conductance) 68–40% below controls over pre- and post-anthesis periods, respectively. Specific mass (dry mass/area) of clipped florets was − 15% of controls, while florets distal to these had specific mass 11% greater than distal or basal florets on unclipped seed heads. These results suggest damaged basal florets provided carbon to unaffected distal florets. This could explain crested wheatgrass’s ability to produce viable seeds under conditions limiting to native bunchgrasses, and presents a novel mechanism germane to the development of convergent drought- and grazing-tolerance traits important to arid and semi-arid rangeland plant community resilience to climate variability.
Certifying Fully Dynamic Algorithms for Recognition and Hamiltonicity of Threshold and Chain Graphs
Authors: Beisegel Jesse , Köhler Ekkehard , Scheffler Robert , Strehler Martin 
Published: March 2023

AbstractSolving problems on graphs dynamically calls for algorithms to function under repeated modifications to the graph and to be more efficient than solving the problem for the whole graph from scratch after each modification. Dynamic algorithms have been considered for several graph properties, for example connectivity, shortest paths and graph recognition. In this paper we present fully dynamic algorithms for the recognition of threshold graphs and chain graphs, which are optimal in the sense that the costs per modification are linear in the number of modified edges. Furthermore, our algorithms also consider the addition and deletion of sets of vertices as well as edges. In the negative case, i.e., where the graph is not a threshold graph or chain graph anymore, our algorithms return a certificate of constant size. Additionally, we present optimal fully dynamic algorithms for the Hamiltonian cycle problem and the Hamiltonian path problem on threshold and chain graphs which return a vertex cutset as certificate for the non-existence of such a path or cycle in the negative case.
The physiology of intraoperative error: using electrokardiograms to understand operator performance during robot-assisted surgery simulations
Authors: D’Ambrosia Christopher , Aronoff-Spencer Eliah , Huang Estella Y. , Goldhaber Nicole H. , Jacobsen Garth R. , Sandler Bryan , Horgan Santiago , Appelbaum Lawrence G. , Christensen Henrik , Broderick Ryan C. 
Published: March 2023

Abstract
Background
No platform for objective, synchronous and on-line evaluation of both intraoperative error and surgeon physiology yet exists. Electrokardiogram (EKG) metrics have been associated with cognitive and affective features that are known to impact surgical performance but have not yet been analyzed in conjunction with real-time error signals using objective, real-time methods.

Methods
EKGs and operating console point-of-views (POVs) for fifteen general surgery residents and five non-medically trained participants were captured during three simulated robotic-assisted surgery (RAS) procedures. Time and frequency-domain EKG statistics were extracted from recorded EKGs. Intraoperative errors were detected from operating console POV videos. EKG statistics were synchronized with intraoperative error signals.

Results
Relative to personalized baselines, IBI, SDNN and RMSSD decreased 0.15% (S.E. 3.603e−04; P = 3.25e−05), 3.08% (S.E. 1.603e−03; P < 2e−16) and 1.19% (S.E. 2.631e−03; P = 5.66e−06), respectively, during error. Relative LF RMS power decreased 1.44% (S.E. 2.337e−03; P = 8.38e−10), and relative HF RMS power increased 5.51% (S.E. 1.945e−03; P < 2e−16).

Conclusions
Use of a novel, on-line biometric and operating room data capture and analysis platform enabled detection of distinct operator physiological changes during intraoperative errors. Monitoring operator EKG metrics during surgery may help improve patient outcomes through real-time assessments of intraoperative surgical proficiency and perceived difficulty as well as inform personalized surgical skills development.

Graphical abstract
Impact of the COVID-19 pandemic on body mass index in children and adolescents after kidney transplantation
Authors: Kanzelmeyer Nele Kirsten , Weigel Friederike , Boeckenhauer Johannes , Haffner Dieter , Oh Jun , Schild Raphael 
Published: March 2023

Abstract
Background
The coronavirus SARS-CoV-2 disease (COVID-19) pandemic affected lifestyles and resulted in significant weight gain in the general population. Its impact on children after kidney transplantation (KTx) is unknown.

Methods
We retrospectively evaluated body mass index (BMI) z-scores during the COVID-19 pandemic in 132 pediatric KTx patients, followed-up at three German hospitals. Among those, serial blood pressure measurements were available for 104 patients. Lipid measurements were available from 74 patients. Patients were categorized according to gender and age group, i.e., children versus adolescents. Data were analyzed by a linear mixed model approach.

Results
Before the COVID-19 pandemic, female adolescents presented with higher mean BMI z-scores compared to male adolescents (difference: − 1.05, 95% CI − 1.86 to − 0.24, p = 0.004). No other significant differences could be observed among the other groups. During the COVID-19 pandemic, the mean BMI z-score increased in adolescents (difference: male, 0.23, 95% CI 0.18 to 0.28; female 0.21, 95% CI 0.14 to 0.29, each p < 0.001), but not in children. The BMI z-score was associated with adolescent age, and with the combination of adolescent age, female gender, and the duration of the pandemic (each p < 0.05). During the COVID-19 pandemic, the mean systolic blood pressure z-score significantly increased in female adolescents (difference: 0.47, 95% CI 0.46 to 0.49).

Conclusions
During the COVID-19 pandemic, adolescents in particular showed a significant increase in their BMI z-score after KTx. Additionally, an increase in systolic blood pressure was associated with female adolescents. The findings suggest additional cardiovascular risks in this cohort.

Graphical abstract
Changing correlations: a flexible definition of non-Gaussian multivariate dependence
Authors: Bárdossy András 
Published: March 2023

AbstractDependencies between variables are often very complex, and may for high values, be different from that of the low values. As the normal distribution and the corresponding copula behave symmetrically for low and high values the frequent application of the normal copula for the description of the dependence may be inappropriate. In this contribution a new way of defining high dimensional multivariate distributions with changing correlations is presented. The method can also be used for a flexible definition of tail dependence. Examples of copulas with linear changing correlations illustrate the methodology. Parameter estimation methods and simulation procedures are discussed. A five dimensional example using groundwater quality data and another four dimensional one using air pollution data, are used to illustrate the methodology.
Feasibility and benefits of home initiation of subcutaneous apomorphine infusion for patients with Parkinson’s disease: the APOKADO study
Authors: Zagnoli Fabien , Leblanc Amélie , Viakhireva-Dovganyuk Irina , Delabrousse-Mayoux Jean-Philippe , Pouyet Alain , Ziegler Marc , Sogni Laura , Patat Marie , Bouillot Régis , Vérin Marc ,   The APOKADO Group, Arhire Andrei , Barres Philippe , Blondiaux Maxime , Bouffeteau Jean-Claude , Brandel Jean-Philippe , Carel Christophe , Castelnovo Giovanni , Coustans Marc , Courault Lucie , Crauser Christian , Degaey Isabelle , Degos Bertrand , Delabrousse Jean-Philippe , Denis Béatrice , Dourneau Marie-Claude , Duretete Arnaud , Feve Jean-Marc François , Follin Erika , Gugenheim Michel , Hubsch Cécile , Patte Karsenti Nathalie , Louchart Pierre , Massengo Serge , Mejias José , Monteiro Homero , Muh Philippe , Pedespan Bernard , Sattler Virginie , Sevin Mathieu , Tir Mélissa , Tirel Badets Anne , Verin Marc , Viakhireva Irina , Vidry Elisabeth , Wiart Jean-Charles 
Published: March 2023

AbstractContinuous subcutaneous apomorphine infusion (CSAI) is used to treat patients with Parkinson’s disease (PD) who are experiencing motor fluctuations. However, the need to initiate this treatment during a hospital stay may restrict patients’ access to it. To assess the feasibility and benefits of initiating CSAI in the patient’s own home. A French prospective multicenter longitudinal observational study (APOKADO) among patients with PD who required subcutaneous apomorphine, comparing in-hospital versus home initiation. Clinical status was assessed according to the Hoehn and Yahr score), the Unified Parkinson’s Disease Rating Scale Part III, and the Montreal Cognitive Assessment. We assessed patients’ quality of life with the 8-item Parkinson’s Disease Questionnaire, rated the improvement in their clinical status on the 7-point Clinical Global Impression–Improvement scale, recorded adverse events, and ran a cost–benefit analysis. 145 patients with motor fluctuations were included in 29 centers (office and hospital). Of these, 106 (74%) were initiated onto CSAI at home, and 38 (26%) in hospital. At inclusion, the two groups were comparable for all demographic and PD characteristics. After 6 months, quality of life, adverse events and early dropout rates were similarly rare-across the two groups. Patients in the home group improved more quickly their quality of life and became more autonomous in managing the device than those in the hospital group, and their care costed less. This study shows that home (versus in-hospital) initiation of CSAI is feasible, improves patients’ quality of life more quickly, with the same level of tolerance. It is also less expensive. This finding should make it easier for patients to access this treatment in the future.
Assessment of aquifer recharge and groundwater availability in a semiarid region of Brazil in the context of an interbasin water transfer scheme
Authors: Costa Alexandre C. , Dupont Fanny , Bier George , van Oel Pieter , Walker David W. , Martins Eduardo S. P. R. 
Published: March 2023

AbstractParticularly in arid and semiarid areas, more and more populations rely almost entirely on imported water. However, the extent to which intentional discharge into transiting river
systems and unintentional leakage may be augmenting water resources for communities along and down gradient of the water transfer scheme has not previously been subject to research. The objective of this study was to assess both the potential of a large-scale water
transfer (WT) scheme to increase groundwater availability by channel transmission losses in a large dryland aquifer system (2,166 km²) in Brazil, and the capability of the receiving streams to transport water downstream under a prolonged drought. An integrated surface-water/groundwater model was developed to improve the estimation of the groundwater resources, considering the spatio-temporal variability of infiltrated rainfall for aquifer
recharge. Aquifer recharge from the WT scheme was simulated under prolonged drought conditions, applying an uncertainty analysis of the most influential fluxes and parameters. The annual recharge (66 mm/year) was approximately twice the amount of water abstracted
(1990–2016); however, the annual recharge dropped to 13.9 mm/year from 2012 to 2016, a drought period. Under similar drought conditions, the additional recharge (6.89 × 106 m³/year) from the WT scheme did not compensate for the decrease in groundwater head in areas that
do not surround the receiving streams. Actually, the additional recharge is counteracted by a decrease of 25% of natural groundwater recharge or an increase of 50% in pumping rate; therefore, WT transmission losses alone would not solve the issue of the unsustainable management of groundwater resources.
Inequality constrained stochastic nonlinear optimization via active-set sequential quadratic programming
Authors: Na Sen , Anitescu Mihai , Kolar Mladen 
Published: March 2023

AbstractWe study nonlinear optimization problems with a stochastic objective and deterministic equality and inequality constraints, which emerge in numerous applications including finance, manufacturing, power systems and, recently, deep neural networks. We propose an active-set stochastic sequential quadratic programming (StoSQP) algorithm that utilizes a differentiable exact augmented Lagrangian as the merit function. The algorithm adaptively selects the penalty parameters of the augmented Lagrangian, and performs a stochastic line search to decide the stepsize. The global convergence is established: for any initialization, the KKT residuals converge to zero almost surely. Our algorithm and analysis further develop the prior work of Na et al. (Math Program, 2022. https://doi.org/10.1007/s10107-022-01846-z). Specifically, we allow nonlinear inequality constraints without requiring the strict complementary condition; refine some of designs in Na et al. (2022) such as the feasibility error condition and the monotonically increasing sample size; strengthen the global convergence guarantee; and improve the sample complexity on the objective Hessian. We demonstrate the performance of the designed algorithm on a subset of nonlinear problems collected in CUTEst test set and on constrained logistic regression problems.