bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORC2 restriction factor silences HIV proviral expression
Authors: Lasserre Angélique , Marie Sébastien , Morel Marina , Martin Michael M. , Legrand Alexandre , Vauthier Virginie , Cimarelli Andrea , Etienne Lucie , Margottin-Goguet Florence , Matkovic Roy 
Published: March 2023

AbstractThe HUSH complex (composed of TASOR, MPP8 and periphilin) represses HIV-1 expression from its promoter by inducing both propagation of repressive epigenetic marks and degradation of the nascent transcript. Vpx from HIV-2, and Vpr proteins from some simian lentiviruses (SIVs), antagonize HUSH, thereby increasing proviral expression. The chromatin-remodelling MORC2 protein plays a critical role in the epigenetic silencing of host genes by HUSH. Here, we deciphered the role of MORC2 in retroviral silencing. We show that MORC2, in contrast to HUSH components, presents strong signatures of positive selection during primate evolution. Like HUSH, MORC2 represses proviral expression in two models of HIV-1 latency. However, while HUSH is degraded upon HIV-2 infection in a Vpx-dependent manner, MORC2 levels are increased, raising the question of a feedback control mechanism without HUSH. Upon infection with an HIV-1-derived virus, MORC2 and TASOR antiviral effects are interdependent. However, once the lentiviral DNA is integrated into the host genome, MORC2 may maintain the repression independently of HUSH. At the post-transcriptional level, both MORC2 and HUSH act in association with CNOT1 of the CCR4-NOT deadenylase complex and the TRAMP-like PAXT complex. Finally, MORC2, but not HUSH components, is expressed in primary quiescent CD4+ T cells. Altogether, our data highlight MORC2 as an HIV restriction factor and a chromatin remodelling protein operating both at the transcriptional and post-transcriptional levels. We speculate that MORC2 could serve as an immune gatekeeper following HUSH inactivation by Vpx and contribute to the maintenance of retroviral silencing in reservoir CD4+ T cells.Significance statementOne hurdle to HIV eradication is viral latency, which refers to the persistence of the virus in reservoir cells despite antiretroviral treatment. The HUSH complex represses HIV expression, once the viral genome is integrated into the host genome. HUSH activity on host genes depends on MORC2, a protein incriminated in the Charcot-Marie-Tooth neuronal disease. Here, we first show that MORC2 presents signs of evolutionary arms-races in primates. Furthermore, MORC2 contributes to HIV silencing in cooperation with HUSH, but also, likely without HUSH. Despite identified as a chromatin remodeler, MORC2 also works at a post-transcriptional level. Altogether, MORC2 appears as a host defense factor, which plays a role in HIV latency.
NETosis Induced by Serum of Patients with COVID-19 is Reduced with Reparixin or Antibodies Against DEK and IL-8
Authors: Kılıç İrfan Baki , Yaşar Açelya , Yalım Camcı İrem , Güzel Türkan , Karahasan Ayşegül , Yağcı Tamer , Çine Naci , Kandilci Ayten 
Published: March 2023

ABSTRACTDEK locates in the nucleus of the cells or the cytoplasmic granules of neutrophils and plays different roles in cellular processes including NETosis, a suicide mechanism of neutrophils. Here we showed that the interaction of rDEK with CXCR2 leads to NETosis, which could be reduced by the CXCR1/CXCR2 inhibitor reparixin. We found that IL-8, IL-6, IL1-β, MPO, and CitH3 were increased whereas DEK was decreased in the serum of COVID-19 patients. Interestingly, reparixin or anti-DEK antibody reduced the NETosis induced by the serums of patients, suggesting that initial cytokine stimulation may further induce the release of DEK. Our results support the use of reparixin as a potential therapeutic strategy in COVID-19 and suggest that DEK-CXCR2 interaction plays a role in NETosis.
A counterfactual analysis of the impact of the 2008 and 2020 crises on Spanish employment
Authors: Jerez Miguel , Montealegre-Luna Alejandra , Garcia-Hiernaux Alfredo 
Published: March 2023

PurposeThe purpose of this paper is to estimate the impact of the 2008 and 2020 economic crises on employment in Spain.Design/methodology/approachThe authors perform a counterfactual analysis, combining intervention (interrupted time series) analysis and conditional forecasting to estimate a “crisis-free” scenario. These counterfactual estimates are used as a synthetic control, to be compared with the observed values of the main variables of the Spanish Labor Force Survey (EPA).FindingsThe authors measure the effect on Spanish employment of the 2008 recession and the ongoing COVID/Ukraine crisis and the speed of recovery, which yields a rigorous dating for the beginning and end of the crises studied. Finally, the authors provide estimates about which part of the employed and unemployed people was in furlough (ERTE) based on microdata provided by the Spanish Institute of Statistics.Originality/valueTo the best of the authors’ knowledge, there are no counterfactual studies covering all the basic variables in EPA and no estimates for the effect of ERTEs on the basic employment variables. Finally, the authors combine well-known intervention and forecasting techniques into an integrated framework to assess the effects of both, past and ongoing crises.
An effective high-order five-point stencil, based on integrated-RBF approximations, for the first biharmonic equation and its applications in fluid dynamics
Authors: Mai-Duy Nam , Tien Cam Minh Tri , Strunin Dmitry , Karunasena Warna 
Published: March 2023

Purpose
The purpose of this paper is to present a new discretisation scheme, based on equation-coupled approach and high-order five-point integrated radial basis function (IRBF) approximations, for solving the first biharmonic equation, and its applications in fluid dynamics.

Design/methodology/approach
The first biharmonic equation, which can be defined in a rectangular or non-rectangular domain, is replaced by two Poisson equations. The field variables are approximated on overlapping local regions of only five grid points, where the IRBF approximations are constructed to include nodal values of not only the field variables but also their second-order derivatives and higher-order ones along the grid lines. In computing the Dirichlet boundary condition for an intermediate variable, the integration constants are used to incorporate the boundary values of the first-order derivative into the boundary IRBF approximation.

Findings
These proposed IRBF approximations on the stencil and on the boundary enable the boundary values of the derivative to be exactly imposed, and the IRBF solution to be much more accurate and not influenced much by the RBF width. The error is reduced at a rate that is much greater than four. In fluid dynamics applications, the method is able to capture well the structure of steady highly non-linear fluid flows using relatively coarse grids.

Originality/value
The main contribution of this study lies in the development of an effective high-order five-point stencil based on IRBFs for solving the first biharmonic equation in a coupled set of two Poisson equations. A fast rate of convergence (up to 11) is achieved.
Counteracting dark sides of robo-advisors: justice, privacy and intrusion considerations
Authors: Aw Eugene Cheng-Xi , Leong Lai-Ying , Hew Jun-Jie , Rana Nripendra P. , Tan Teck Ming , Jee Teck-Weng 
Published: March 2023

PurposeUnder the pressure of dynamic business environments, firms in the banking and finance industry are gradually embracing Fintech, such as robo-advisors, as part of their digital transformation process. While robo-advisory services are expected to witness lucrative growth, challenges persist in the current landscape where most consumers are unready to adopt and even resist the new service. The study aims to investigate resistance to robo-advisors through the privacy and justice perspective. The human-like attributes are modeled as the antecedents to perceived justice, followed by the subsequent outcomes of privacy concerns, perceived intrusiveness and resistance.Design/methodology/approachAn online survey was conducted to gather consumer responses about their perceptions of robo-advisors. Two hundred valid questionnaires were collected and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM).FindingsThe results revealed that (1) perceived anthropomorphism and perceived autonomy are the positive determinants of perceived justice, (2) perceived justice negatively impacts privacy concerns and perceived intrusiveness and (3) privacy concerns and perceived intrusiveness positively influence resistance to robo-advisors.Originality/valueThe present study contributes to robo-advisory service research by applying a privacy and justice perspective to explain consumer resistance to robo-advisors, thereby complementing past studies that focused on the technology acceptance paradigm. The study also offers practical implications for mitigating resistance to robo-advisors.
Impact of monetary policy rate on commercial banks' lending rate: empirical evidence from Ghana
Authors: Kamasa Kofi , Afful Solomon Luther , Bentum-Ennin Isaac 
Published: March 2023

PurposeThis paper seeks to examine the effect of monetary policy rate (MPR) on the lending rates of commercial banks in Ghana.Design/methodology/approachThe paper employed the autoregressive distributed lag (ARDL) model as well as the non-linear autoregressive distributed lag (NARDL) model econometric techniques on a quarterly time series data from 2002 to 2018.FindingsThe ARDL results revealed that, MPR has a positive and significant effect on lending rate in the long and short run. Although there exists a direct relationship between MPR and lending rate, from the NARDL revealed an asymmetric effect of MPR on lending rate to the effect that, lending rate in Ghana responds more to positive shock (a rise in MPR) compared to a negative shock (a decrease in MPR) both in the long and short run.Originality/valueThe paper contributes to policy and literature in Ghana by providing empirical evidence on the asymmetric effect that MPR has on lending rates in Ghana. The paper recommends among others, the establishment of a rating system of banks according to their monetary policy compliance, where highly rated banks could have for instance a reduction on borrowed reserves from the central bank.
Impact of delightful somatosensory augmented reality experience on online consumer stickiness intention
Authors: Huang Tseng-Lung , Chung Henry F.L. 
Published: March 2023

PurposeDrawing on embodied cognition theory, this study examined the impact of midair, gesture-based somatosensory augmented reality (AR) experience on consumer delight and stickiness intention. The mediating effects of three psychological states for body schema (i.e. natural symbol sets, vivid memory and human touch) on the relationships between somatosensory AR and consumer delight/stickiness intention are determined. By filling gaps in the research, we hope to provide guidance on how to drive delightful somatosensory AR marketing.Design/methodology/approachTwo experiments were conducted (Study 1 and Study 2) to test the research model and hypotheses. These experiments compared the effects of the “presence” (midair, gesture-based) and “absence” (mouse-based traditional website) conditions in somatosensory AR on consumer body schema and the creation of a delightful virtual shopping experience (i.e. consumer delight and stickiness intention).FindingsThe consumer delight and stickiness intention created in the presence condition was much higher than those in the absence condition. Consumers appeared to prefer engaging in a midair gesture-based somatosensory AR experience and exploring an augmented metaverse reality to interacting with a mouse-based traditional website. We also found that giving online consumers more somatosensory activities and kinesthetic experiences effectively inspired three psychological states of body schema in online consumers.Originality/valueThe results contribute to the AR experience and somatosensory marketing literature by revealing the role of natural symbol sets, vivid memory and the sense of human touch. This research breaks through the long-developed research paradigm on consumer delight, which has been limited to traditional entities and web contexts. We also extend embodied cognition theory to the study of somatosensory AR marketing.
Examining the issue of employee intentions to learn and adopt digital technology
Authors: Chaudhuri Ranjan , Chatterjee Sheshadri , Vrontis Demetris , Galati Antonino , Siachou Evangelia 
Published: March 2023

PurposeIn the post-COVID-19 era, the hospitality industry is rapidly moving towards digitalization, which requires employees to upgrade their knowledge and skills. Some employees resist those changes and refuse to upgrade their knowledge, skills and ways of doing things. Therefore, there is a need to understand this unexplored area and so this study examines employee intentions to embrace digital technology from the perspective of upgrading their skills and knowledge. The study investigates the moderating role of the employees' resistance to change motive (RCM) on their intention to embrace digital technology, especially in the post-COVID-19 pandemic scenario.Design/methodology/approachThe research is conducted using dynamic capability view (DCV) theory and status quo bias (SQB) theory. Drawing on the existing literature in this area, a theoretical model is developed, which is validated using the structural equation modelling technique to analyse data from hospitality industry employees.FindingsThe results indicate that employees' dynamic capability plays a significant role in employees' upgrading their skill and knowledge capabilities, and this significantly improves employee intention to embrace digital technology. It also finds that the employee RCM plays a significant role in the relationship between upgrading skill capability and their knowledge capability to relation to embracing digital technology.Originality/valueThe findings could be used by hospitality managers to better understand employee intentions with regard to adopting digital technology, challenges faced and the way forward.
Executive Compensation Tied to ESG Performance: International Evidence
Authors: COHEN SHIRA , KADACH IGOR , ORMAZABAL GAIZKA , REICHELSTEIN STEFAN 
Published: March 2023

ABSTRACTUsing a wide sample of international publicly traded firms, this paper studies the rapidly increasing practice of incorporating Environmental, Social, and Governance (ESG) metrics in executive compensation contracts. Our evidence suggests that this compensation practice varies at the country, industry, and firm levels in ways that are consistent with efficient incentive contracting. We also observe that reliance on ESG metrics in executive compensation arrangements is associated with engagement, voting, and trading by institutional investors, which suggests that firms could be adopting this practice to align their management's objectives with the preferences of certain shareholder groups. Finally, we find that the adoption of ESG Pay is accompanied by improvements in key ESG outcomes, but not by improvements in financial performance.
Cold atmospheric plasma‐induced protein modification: Novel nonthermal processing technology to improve protein quality, functionality, and allergenicity reduction
Authors: Olatunde Oladipupo Odunayo , Hewage Anuruddika , Dissanayake Thilini , Aluko Rotimi E. , Karaca Asli Can , Shang Nan , Bandara Nandika 
Published: March 2023

AbstractWith the constant increase in protein demand globally, it is expedient to develop a strategy to effectively utilize protein, particularly those extracted from plant origin, which has been associated with low digestibility, poor techno‐functional properties, and inherent allergenicity. Several thermal modification approaches have been developed to overcome these limitations and showed excellent results. Nevertheless, the excessive unfolding of the protein, aggregation of unfolded proteins, and irregular protein crosslinking have limited its application. Additionally, the increased consumer demand for natural products with no chemical additives has created a bottleneck for chemical‐induced protein modification. Therefore, researchers are now directed toward other nonthermal technologies, including high‐voltage cold plasma, ultrasound, high‐pressure protein, etc., for protein modification. The techno‐functional properties, allergenicity, and protein digestibility are greatly influenced by the applied treatment and its process parameters. Nevertheless, the application of these technologies, particularly high‐voltage cold plasma, is still in its primary stage. Furthermore, the protein modification mechanism induced by high‐voltage cold plasma has not been fully explained. Thus, this review meets the necessity to assemble the recent information on the process parameters and conditions for modifying proteins by high‐voltage cold plasma and its impact on protein techno‐functional properties, digestibility, and allergenicity.
Pulsed electric field using the needle–needle electrodes for improving the salt diffusion of pork brine salting
Authors: Dong Zhiqin , Li Xinfu , Liu Zhao , Wang Yuhan , Xiong Qiang 
Published: March 2023

AbstractPulsed electric field (PEF), as an emerging nonthermal processing technology, has attracted extensive attention and research in food processing. In the present study, PEF has been approved that has the potential to enhance salt diffusion in pork. In this study, pork lions were pretreated with PEF before being immersed in the brine (5% NaCl [w/w]) at 4°C to investigate the effect of needle–needle PEF pretreatment on pork brine salting. The changes in the weight, moisture, and salt content were detected during the salting process. The effective diffusion coefficient (De) and mass transfer kinetics were calculated. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were subsequently used to analyze the microstructure of the pork and the secondary structure of myofibrillar proteins (MPs). The outcomes demonstrated that after brining for 8 h with PEF pretreatment, the weight, moisture, and salt changes increased significantly. The central salt content achieved by 12 h brining after PEF treatment (4.5 kV) is equivalent to that achieved by brining for 20 h without any treatment. The De was raised to 4.0 × 10−10 (PEF) from 3.1 × 10−10 (control). SEM and FTIR results revealed that PEF altered the microstructure of pork and the secondary structure of MP. Our study demonstrated that PEF generated by needle–needle electrodes could effectively promote salt diffusion and shorten salting processing.
A survey of compliance with stereotactic ablative body radiotherapy quality recommendations
Authors: Claridge Mackonis Elizabeth Ruth , Hardcastle Nick , Haworth Annette 
Published: March 2023

AbstractIntroductionMany publications have proposed quality standards for stereotactic ablative body radiotherapy (SABR). However, data on the level of compliance with these guidelines is lacking in the literature. This study aimed to understand how these guidelines are applied in the clinic and to identify barriers to implementing such recommendations.MethodsInterviews were conducted with multidisciplinary staff at radiation oncology centres across New South Wales formulated around the RANZCR Guidelines for Safe Practice of Stereotactic Body (Ablative) Radiation Therapy. The interview responses were grouped into 20 topics, assessed against the guidelines and thematically analysed.ResultsGood compliance with the guidelines was found, with more than 80% of centres achieving satisfactory results in more than half the topics. The areas with the lowest compliance were auditing, risk assessment and reporting recommendations. Barriers to the quality of SABR treatments included limited training opportunities, low patient numbers and a lack of clear requirements on comprehensive auditing and reporting.ConclusionOverall, the centres surveyed reported good compliance with most of the RANZCR SABR guidelines. The tasks with the lowest compliance were those that monitor quality outcomes. Potential strategies for improvement include inclusion in clinical trials and the use of databases which link treatment parameters, dosimetry and outcomes. Further work will focus on the barriers identified in this survey and propose practical solutions to improve compliance in these areas.
Using metatranscriptomics to better understand the role of microbial nitrogen cycling in coastal sediment benthic flux denitrification efficiency
Authors: Marshall Alexis J. , Phillips Lori , Longmore Andrew , Hayden Helen L. , Tang Caixian , Heidelberg Karla B. , Mele Pauline 
Published: March 2023

AbstractSpatial and temporal variability in benthic flux denitrification efficiency occurs across Port Phillip Bay, Australia. Here, we assess the capacity for untargeted metatranscriptomics to resolve spatiotemporal differences in the microbial contribution to benthic nitrogen cycling. The most abundant sediment transcripts assembled were associated with the archaeal nitrifier Nitrosopumilus. In sediments close to external inputs of organic nitrogen, the dominant transcripts were associated with Nitrosopumilus nitric oxide nitrite reduction (nirK). The environmental conditions close to organic nitrogen inputs that select for increased transcription in Nitrosopumilus (amoCAB, nirK, nirS, nmo, hcp) additionally selected for increased transcription of bacterial nitrite reduction (nxrB) and transcripts associated with anammox (hzo) but not denitrification (bacterial nirS/nirk). In sediments that are more isolated from external inputs of organic nitrogen dominant transcripts were associated with nitrous oxide reduction (nosZ) and changes in nosZ transcript abundance were uncoupled from transcriptional profiles associated with archaeal nitrification. Coordinated transcription of coupled community‐level nitrification–denitrification was not well supported by metatranscriptomics. In comparison, the abundance of archaeal nirK transcripts were site‐ and season‐specific. This study indicates that the transcription of archaeal nirK in response to changing environmental conditions may be an important and overlooked feature of coastal sediment nitrogen cycling.
Children's book illustrations from China and Ukraine: Comparison of different formats
Authors: Wang Hanping 
Published: March 2023

AbstractThis study was aimed at comparing different formats of illustrations for children's books created by modern Chinese and Ukrainian artists. At the same time, it was not focused just on determining the leading format, but on identifying the attractiveness factors of each format. To this end, the study investigated children's illustration preferences drawing from the following three age groups: 5–6 years old (preschoolers), 7–8 years old (second‐graders), and 9–10 years old (fourth‐graders). According to the survey, children were most concerned with illustration colourfulness (this is true for paper and pop‐up books) and viewing convenience. There were no statistically significant differences found between Chinese and Ukrainian books in terms of these parameters. At the same time, Chinese e‐books appeared to outperform the Ukrainian texts in terms of feature management and illustration colourfulness. Publishers and artists of children's books can use these data for effective creative activity and making constructive decisions. At the same time, these findings may be of interest to parents, informing or guiding book selection for children.