bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent: provider connectedness and STI risk reduction following a brief alcohol intervention: findings from a randomized controlled trial
Authors: Dash Genevieve F. , Bryan Angela D. , Yang Manshu , Chung Tammy , Hudson Karen A. , Feldstein Ewing Sarah W. 
Published: July 2023

ObjectiveGiven the frequent co-occurrence between alcohol use and sexual behavior among adolescents, alcohol interventions may play a role in helping prevent sexually transmitted infections (STIs) in this age group. Psychotherapy “common factors” are one potential active ingredient in intervention efficacy. Thus, the purpose of this study was to evaluate the influence of a critical common factor, adolescent: provider connectedness, on STI risk reduction at 3 months post-intervention.MethodsCommunity-based youth (N = 168) were randomized to two 60-min individual sessions of either motivational interviewing (MI) or brief adolescent mindfulness (BAM). Logistic regressions predicted post-intervention positive STI from adolescent: provider connectedness, intervention condition, and their interaction. Path analytic models tested post-intervention hazardous drinking as a mediator of the association between adolescent: provider connectedness and reduction in STI risk at 3-month follow-up.ResultsStronger adolescent: provider connectedness reduced risk of STI at 3 months post-intervention, with no differences by treatment condition. A mediational relationship between adolescent: provider connectedness and STI risk via hazardous drinking was not observed.ConclusionPsychotherapeutic common factors, including adolescent: provider connectedness, may be important in mitigating adolescent health risk in behavioral interventions, above and beyond intervention condition and beyond the target behavior of the intervention.
Study of Auditory Brainstem Evoked Response at Varying Frequencies in Subclinical Hypothyroid Subjects
Authors: Jha Indira , Alam Kabir , Keshari Kaushal K. , Sinha Niska , Kumar Tarun 
Published: July 2023

Background:
Hearing deterioration in hypothyroid subject was documented by Kemp. Cristiane et al. reported delayed waves latency in subclinical hypothyroid subjects. Recording of auditory brain stem evoked response in subclinical hypothyroid subjects at 80 dB and varying frequencies has been done.

Materials and Methods:
Case control study. Group 1, N = 30 control subjects, free T3, free T4, thyroid stimulating hormone (TSH) within normal range. Group 2, N = 30 subclinical hypothyroid subjects, TSH was between 4.6-8 microIU/L. Student Unpaired t test was done. Those on epileptic, neuroleptics, depression, psychosis drugs, inflammatory, proliferative, traumatic ear disorder, smokers, on tobacco, COVID-19 positive subjects, altered sensorium, drug abuse, diabetes mellitus, neuropathy, hypertension, cardiac arrhythmia, family history of hearing disorder, and furosemide drug were excluded. Auditory brainstem evoked response (ABER) done.

Results:
Mean ± SD of Brainstem evoked response auditory (BERA) waves III, V, interpeak latencies at 80 dB, 2, 4,6 KHz reported delay and significant in subclinical hypothyroid group as compared to control.

Conclusion:
BERA study at 6 KHz and 80 dB detects central neuropathy earlier in subclinical hypothyroid patients.
Proportion of Physicians Who Treat Patients With Greater Social and Clinical Risk and Physician Inclusion in Medicare Advantage Networks
Authors: Gong Jung Ho , Johnston Kenton J. , Meyers David J. 
Published: July 2023

ImportanceMedicare Advantage (MA) plans are expanding rapidly, now serving 50% of all Medicare enrollees. Little is known about how inclusion rates of physicians in MA plan networks vary by the social and clinical risks of their patients.ObjectiveTo examine the association of physicians caring for patients with higher levels of social and clinical risk in traditional Medicare (TM) with the likelihood of inclusion in MA plan networks.Design, Setting, and ParticipantsThis cross-sectional study evaluated the number of patients of physicians participating in TM Part B in 2019. The data analysis was conducted between June 2022 and March 2023.ExposuresQuintiles of the proportion of patients who were dually eligible for Medicare and Medicaid and average beneficiary hierarchical condition category (HCC) score (a measure of a patient’s chronic disease burden that is used in risk adjustment and MA plan payment, where higher scores indicate higher risk) in the Part B TM program.Main Outcomes and MeasuresThe main outcomes were the proportion of MA plans and enrollees for which physicians were in network.ResultsThe analysis sample included 259 932 physicians billing Medicare Part B in 2019. After adjusting for physician, patient, and county characteristics, physicians with the highest quintile of patients with dual eligibility were associated with a lower likelihood of being included in MA plans and being in network with MA enrollees than the lowest quintile physicians (MA inclusion rate, −3.0% [95% CI, −3.2% to −2.8%]; P &amp;lt; .001; in-network enrollee proportion, −6.5% [95% CI, −7.0% to −6.0%]; P &amp;lt; .001). Similarly, physicians with the highest quintile HCC score were associated with a lower likelihood of being included in MA plans and being in network with MA enrollees than the lowest quintile physicians (MA inclusion rate, −7.5% [95% CI, −7.9% to −7.2%]; P &amp;lt; .001; in-network enrollee proportion, −18.7% [95% CI, −19.5% to −18.1%]; P &amp;lt; .001). Physicians in medical specialties in the highest clinical risk group (highest quintile HCC score) were associated with a significantly lower likelihood of being in network with MA enrollees than those in the lowest clinical risk group (in-network enrollee proportion, −20.4% [95% CI, −21.1% to −19.8%]; P &amp;lt; .001).Conclusions and RelevanceThis cross-sectional study of physicians participating in TM Part B in 2019 found that physicians with higher numbers of patients with social and medical risks in TM were significantly less likely to be associated with MA plans.
Fabrication and Cell Culture Applications of Core‐Shell Hydrogel Fibers Composed of Chitosan/DNA Interfacial Polyelectrolyte Complexation and Calcium Alginate: Straight and Beaded Core Variations
Authors: Utagawa Yoshinobu , Ino Kosuke , Takinoue Masahiro , Shiku Hitoshi 
Published: July 2023

AbstractCore‐shell hydrogel fibers are widely used in cell culture applications. A simple and rapid method is presented for fabricating core‐shell hydrogel fibers, consisting of straight or beaded core fibers, for cell culture applications. The core fibers are prepared using interfacial polyelectrolyte complexation (IPC) with chitosan and DNA. Briefly, two droplets of chitosan and DNA are brought in contact to form an IPC film, which is dragged to prepare an IPC fiber. The incubation time and DNA concentration are adjusted to prepare straight and beaded IPC fibers. The fibers with Ca2+ are immersed in an alginate solution to form calcium alginate shell hydrogels around the core IPC fibers. To the best of the knowledge, this is the first report of core‐shell hydrogel fibers with IPC fiber cores. To demonstrate cell culture, straight hydrogel fibers are applied to fabricate hepatic models consisting of HepG2 and 3T3 fibroblasts, and vascular models consisting of human umbilical vein endothelial cells and 3T3 fibroblasts. To evaluate the effect of co‐culture, albumin secretion, and angiogenesis are evaluated. Beaded hydrogel fibers are used to fabricate many size‐controlled spheroids for fiber and cloning applications. This method can be widely applied in tissue engineering and cell analysis.
Synthesis of Functionalized 2‐Pyrrolidinones Bearing N‐Trifluoromethylphenyl through A Formal [4+1] Cycloaddition of Cinnamaldehyde Nitrones and 1‐Ethynylnaphthalen‐2‐ols
Authors: Wei Cui , Cheng Xiao‐Ling , Chen Yan‐Jie , Liang Cui , Mo Dong‐Liang 
Published: July 2023

AbstractA variety of functionalized 2‐pyrrolidinones bearing N‐trifluoromethylphenyl moieties were prepared in moderate to good yields with high diastereoselectivity through copper(II)‐catalyst and base co‐catalyzed formal [4+1] cycloaddition of cinnamaldehyde nitrones with 1‐ethynylnaphthalen‐2‐ols in the presence of m‐CPBA as the oxidant. The triple bond of 1‐ethynylnaphthalen‐2‐ol served as one‐carbon synthon for the pyrrolidinone ring formation. Mechanistic studies revealed that m‐CPBA played an important role to interrupt the intramolecular O‐cyclization to afford the 2‐pyrrolidinones. Moreover, the reaction could be easily performed at gram scales and the obtained products were selectively converted into diverse pyrroline scaffolds.
Rh‐Catalyzed Hydration/C−F Bond Cleavage of Fluorinated Diazoalkanes Enabling Synthesis of α‐Fluoro‐β‐ketophosphonates
Authors: Wang Qian , Liu Jiang , Mei Haibo , Pajkert Romana , Röschenthaler Gerd‐Volker , Han Jianlin 
Published: July 2023

Abstract(β‐Diazo‐α,α‐difluoroethyl)phosphonates have been emerging as useful building blocks in organic synthetic chemistry in recent years, which can be used as diazo analog or masked carbene for the rapid assembly of difluoromethylene phosphonate‐containing compounds. Herein, we elaborate a method for the synthesis of α‐fluoro‐β‐ketophosphonates from hydration/C−F bond cleavage of in situ generated (β‐amino‐α,α‐difluoroethyl)phosphonates via a Rh‐carbene intermediate. Divers (β‐amino‐α,α‐difluoroethyl)phosphonates are tolerated in this reaction affording α‐fluoro‐β‐ketophosphonates in good yields. This reaction used the in situ generated water as the coupling partner, which represents a reaction of (β‐diazo‐α,α‐difluoroethyl)phosphonates and also a method for generating bioactive α‐fluoro‐β‐ketophosphonates.
Catalytic Hydrosilylation of Imines by Aluminum Hydride Cations
Authors: Bhandari Mamta , Rawat Sandeep , Kaur Mandeep , Singh Sanjay 
Published: July 2023

AbstractIn this work, the catalytic activity of electronically unsaturated three coordinated aluminum hydride cations [LAlH]+[HB(C6F5)3]− (1) and [LAlH]+[B(C6F5)4]− (2) in hydrosilylation of imines has been disclosed (L={(2,6‐iPr2C6H3N)P(Ph2)}2N). A variety of organo‐silanes such as Et3SiH, MePhSiH2, PhSiH3, TMDSO, and PHMS are screened in this endeavour. The amines as products of catalysis were obtained in good to excellent yields after the hydrolysis of silylamine intermediates. Further, a series of controlled experiments systematically designed to investigate the underlying mechanistic pathway through multinuclear NMR analysis showed Lewis adduct formation between cationic aluminum centre and the imine nitrogen, which subsequently undergoes reaction with silane to afford the product. The hydrosilylation of imine performed with Et3SiH using catalyst 1 with a loading of 2 mol % at 60 °C occurs smoothly. Whereas 2 led to the product formation with Et3SiH only when used in stoichiometric quantity. Further, to investigate this unique behaviour of 1 NMR investigations were performed and revealed that the anion in 1 competes for hydride delivery and in‐situ generates B(C6F5)3 that cooperatively reinforces the catalytic activity of 1.
Teachers and students use of systems thinking about their participation in school environmental clubs
Authors: Beach Richard 
Published: July 2023

AbstractThis report describes a study of three English teachers' and three students' participation in two high school environment clubs. Teachers' and students' interview perceptions were analyzed based a critical inquiry systems thinking framework involving inferences of purposes, outcomes, norms, and beliefs/discourses constituting energy/transportation, agriculture/food production, and economic systems impacts on climate change. Interviews were also analyzed in terms of teachers and students assuming roles in club projects and their use of tools mediating their participation in these projects. Teachers and students critiqued the purposes of systems as leading to negative climate change outcomes, as well as norms and beliefs/discourses justifying these systems. They also assumed roles related to fostering sustainability practices, including planting school gardens, supporting recycling/composting, and using tools to inform audiences about their activities. Literacy teachers can draw on the systems thinking framework for general instruction about systems impacting climate change.
3,5,7‐trihydroxyflavone restricts proliferation of androgen‐independent human prostate adenocarcinoma cells by inducing ROS‐mediated apoptosis and reduces tumour growth
Authors: Raza Waseem , Meena Abha , Luqman Suaib 
Published: July 2023

AbstractFlavonoids are among the largest groups of secondary metabolites. Studies suggest that dietary intake of flavonoids reduces the risk of cancer. 3,5,7‐trihydroxyflavone (THF) belongs to the flavone class of flavonoids and potentially inhibits the growth of many cancers; however, it is unexplored in prostate cancer. This study reports the antiproliferative potential of THF in prostate cancer cell line via reactive oxygen species (ROS)‐mediated cascades and examines the tumour reduction potential in swiss albino mice. The potency of THF was evaluated by employing cytotoxicity assays and wound healing assays. Cell cycle, ROS, mitochondrial membrane potential (MMP), and Annexin‐V‐FITC assay were performed using a flow cytometer. In vivo, anticancer potential was achieved using the mice Ehrlich Ascites Carcinoma (EAC) model. THF inhibits cell growth with IC50 of 64.30 µM (MTT), 81.22 µM (NRU) and 25.81 µM (SRB), substantiated by cell migration assay. Cell‐cycle analysis revealed that THF increases the subdiploid population. Furthermore, the Annexin‐V‐FITC assay evoked a significant induction of late apoptosis at a higher concentration of THF. THF also disrupts MMP, caused by an increased generation of ROS. In the EAC model, THF significantly inhibits tumour growth and increases the percent survival of mice and ROS levels in EAC cells. Hence, it may be concluded that THF might execute its antiproliferative effect via inducing ROS generation and could be a promising lead for preclinical and clinical validations.
Incivility and interpersonal harm in organizational context: A qualitative exploration of values in STEM training programs
Authors: Rieger Agnes , Marder Maya A. , Blackburn Allyson M. , Garthe Rachel C. , Aber Mark S. 
Published: July 2023

AbstractThis study investigates science, technology, engineering, and math (STEM) PhD students' perceptions of organizational values and incivility. Interviews with 26 STEM PhD students elicited examples of and perceptions surrounding incivility and related harms. Productivity, prestige, expertise, objectivity, self‐sufficiency, and collaboration values were identified. Each included aspects deemed useful (e.g., productivity fueling discovery; expertise facilitating learning) as well as potentially contributing to harm when weaponized (e.g., productivity appeared in incivility stories when one “looked down” on those who did not work long days; expertise appeared when people gossiped about intelligence). Some aspects of collaboration (e.g., long‐lasting working relationships fueling scientific discovery) may be protective. Organizational values such as productivity appeared to supersede considerations such as well‐being. Current framing of these values may bolster refusal to engage in or support social justice and mental health efforts, which some participants identified as needed. Implications across settings are discussed.
Hyperuricemia promotes the progression of atherosclerosis by activating endothelial cell pyroptosis via the ROS/NLRP3 pathway
Authors: He Bin , Nie Qiangqiang , Wang Feng , Wang Xuming , Zhou Yun , Wang Cheng , Guo Jing , Fan Xueqiang , Ye Zhidong , Liu Peng , Wen Jianyan 
Published: July 2023

AbstractHyperuricemia closely correlates with the development of atherosclerosis, but little is known of the mechanism by which atherosclerosis progression occurs in hyperuricemia. Atherosclerosis appears to involve pyroptosis, an emerging mechanism of proinflammatory regulated cell death. This study tested the hypothesis that pyroptosis underlies the relationship between hyperuricemia and atherosclerosis, using ApoE−/− mice (a model of atherosclerosis), human umbilical vein endothelial cells (HUVECs), and human atherosclerotic arterial samples. We found that hyperuricemia can aggravate the aortic atherosclerotic plaque‐load in ApoE−/− mice and promote endothelial cell pyroptosis. Additionally, hyperuricemia can increase the levels of serum inflammatory factors (including IL‐1β and IL‐18). Exposure to lipopolysaccharide plus a high concentration of soluble uric acid (≥12 mg/dL) induced cell pyroptosis in HUVECs, as evidenced by increased expression of pyroptosis‐related proteins and elevated release of lactate dehydrogenase (a marker of tissue damage). Further, MCC950, a selective nucleotide‐binding oligomerization domain (NOD)‐like receptor 3 (NLRP3) inflammasome inhibitor, and N‐acetyl‐
l‐cysteine, an antioxidant, attenuated HUVEC pyroptosis by inhibiting activation of the NLRP3 inflammasome and production of intracellular reactive oxygen species (ROS). Finally, we detected significantly higher expression of pyroptosis‐associated proteins in carotid specimens from patients with hyperuricemia. Collectively, our findings suggest that hyperuricemia can aggravate endothelial cell pyroptosis in aortic atherosclerotic plaques, promoting the development of atherosclerosis. Additionally, a high concentration of soluble uric acid can trigger the activation stage of the NLRP3 inflammasome, mediating endothelial cell pyroptosis, and this process is regulated by the cellular ROS level.
Acute orchitis deciphered: Coxsackievirus B strains are the main etiology and their presence in semen is associated with acute inflammation and risk of persistent oligozoospermia
Authors: Pilatz Adrian , Arneth Borros , Kaiser Rolf , Heger Eva , Pirkl Martin , Böttcher Sindy , Fritzenwanker Moritz , Renz Harald , Mankertz Annette , Schuppe Hans‐Christian , Wagenlehner Florian 
Published: July 2023

AbstractAlthough various viruses are considered to be the clinical cause for acute orchitis, it is completely unclear to what extent and which viruses are etiologically involved in acute orchitis and what the clinic and course of these patients are like. Therefore, a prospective study was set up to decipher acute isolated orchitis. Between July 2007 and February 2023, a total of 26 patients with isolated orchitis were recruited and compared with 530 patients with acute epididymitis. We were able to show for isolated orchitis, that (1) orchitis is usually of viral origin (20/26, 77%) and enteroviruses with coxsackievirus B strains (16/26, 62%) are predominant, (2) virus isolates could be received from semen indicating the presence of replication‐competent virus particles, (3) a polymerase chain reaction (PCR) for enteroviruses should be conducted using semen provided at the onset of disease, because the virus is not detectable in serum/urine, (4) there is a circannual occurrence with the maximum in summer, (5) orchitis is associated with a characteristic inflammatory cytokine panel in the semen and systemic inflammation, (6) orchitis is usually rapidly self‐limiting, and (7) about 30% of patients (6/20) suffer ongoing oligozoospermia. These seven emerging aspects are likely to fundamentally change thinking and clinical practice regarding acute isolated orchitis.
Generation of bright‐dark Q‐switched pulse pair in thulium‐doped fiber laser cavity with titanium aluminum carbide absorber
Authors: Omar Suziana , Musa Baktiar , Rosol Ahmad Haziq Aiman , Jusoh Zulzilawati , Yasin Moh , Harun Sulaiman Wadi 
Published: July 2023

AbstractThe proposed titanium aluminum carbide (Ti3AlC2) film‐based saturable absorber (SA) for Q‐switching in thulium‐doped fiber laser (TDFL) cavity offers a cost‐effective and practical alternative to conventional SA materials such as graphene or semiconductor. The Ti3AlC2 film was produced using a simple and low‐cost casting approach with polyvinyl alcohol as a binder. The SA was devised from the film using a sandwich‐structured fiber‐ferrule platform and integrated into a TDFL ring cavity. The generated Q‐switched pulses were stable and had a repetition rate of up to 20.82 kHz with a minimum pulse width of 3.167 µs and a maximum pulse energy of 58.12 nJ. The Q‐switched laser produced the bright‐dark pulse pair. These results demonstrate the potential of Ti3AlC2 as a promising SA material for practical applications in the field of fiber lasers.
Self‐monitoring with goal‐setting: Decreasing disruptive behavior in children with attention‐deficit/hyperactivity disorder
Authors: McKenna Kara , Bray Melissa A. , Fitzmaurice Brenna , Choi Dowon , DeMaio Erin , Bray Clark R. , Bernstein Carly 
Published: July 2023

AbstractThis study sought to investigate the effects of a self‐monitoring (SM) with goal‐setting (GS) intervention on students' disruptive behavior. A multiple baseline A‐B‐BC design was implemented across five elementary school‐aged participants diagnosed with attention‐deficit/hyperactivity disorder (ADHD) to examine the use of a behavioral intervention combining SM and GS techniques to decrease disruptive behavior. The results of this study suggest that SM with GS appears to be an effective intervention package for decreasing the disruptive behavior of students with ADHD and that these behavioral decreases sustain after intervention completion. Results also suggest moderate benefits of using a SM with GS intervention over a SM intervention. Teacher ratings suggest that the SM with GS package is moderately acceptable for classroom use.
Emotional neglect and posttraumatic growth among Chinese adolescents: A moderated mediation model of psychological suzhi and school engagement
Authors: Chen Yang , Zhan Shenshen , Zhao Xinyi , Chen Siyuan , Yin Huazhan 
Published: July 2023

AbstractEmotional neglect is an under‐recognized but relatively common type of childhood maltreatment. Although it has been reported that adolescents will facilitate positive growth after experiencing childhood maltreatment, such as sexual abuse, it is unknown whether adolescents could also get a promotion after experiencing emotional neglect. Thus, we aimed to examine the association between emotional neglect and posttraumatic growth (PTG) and further explored the potential influence factors underlying such association. Six hundred and thirty‐five adolescents (55.2% female, Mage = 14.12 years old, SD = 1.47) were asked to complete self‐report questionnaires regarding emotional neglect, school engagement, psychological suzhi, and PTG. Results showed that emotional neglect was negatively associated with PTG, and school engagement mediated such association. Further, psychological suzhi moderated the direct pathway from emotional neglect to PTG in which the deleterious effect of emotional neglect on PTG was weaker for adolescents who reported higher psychological suzhi. Meanwhile, psychological suzhi moderated the indirect pathway from emotional neglect to school engagement in the mediated model in which the deleterious effect of emotional neglect on school engagement was weaker for adolescents who reported higher psychological suzhi. Overall, the current study advances our understanding of the relationship between emotional neglect and PTG, and further tests the potential roles of school engagement and psychological suzhi in this relationship.