bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Vitamin D in Management of Diabetes and Unresolved Cardiovascular
Diseases
Authors: Upadhyay Prabhat Kumar , Thakur Navneet , Vishwakarma Vishal Kumar , Srivastav Ritesh Kumar , Ansari Tarique Mahmood 
Published: September 2023

Background:
Vitamin D deficiency is becoming a widely recognized global health issue.
Serum values of 25(OH) vitamin D (<20 ng/ml) are used to identify vitamin D deficiency. By
prompting vascular endothelial cells to activate their nuclear receptor in cardio-myocytes, Vitamin
D regulates obesity, Renin-angiotensin system (RAS), energy consumption, and pancreatic cell
function. Vitamin D deficiency has been associated with diabetes, asthma, hyperlipidaemia, and
pulmonary hypertension in humans.

Methods:
PubMed and Google Scholar databases were utilised to search the literature on vitamin
D and related diseases.

Result:
It is also linked to an elevated risk of death and heart disease. On the other hand, metaanalyses
of vitamin D intervention and trials have found no substantial changes in insulin sensitivity,
lipid markers, or blood pressure, which result in the association between deficiency of vitamin
D and cardiovascular disease.

Conclusion:
In this review, we present the most recent research on the effects of Vitamin D therapy
on various cardiovascular diseases and diabetes, and explain the underlying mechanisms.
The Intersection between Alcohol use and Sexual Activity among Young Adult Male U.S. Service Members
Authors: Orchowski Lindsay M. , Meerhaeghe Bryce M , Lane Amber R. , Kazemi Donna M. , Borsari Brian , Berry-Cabán Cristóbal S. 
Published: September 2023

Aims:The current study explores drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior among young adult male active duty service members in the United States.Background:Hazardous alcohol use is a significant problem among United States military service members. Whereas the association between alcohol use and sexual assault is well documented in civilian samples, less is known regarding the intersection of alcohol use and sexual activity among soldiers.Objective:Descriptive statistics were utilized to summarize drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior.Methods:A sample of 338 active-duty male service members between the ages of 18 and 24 were recruited from a large military post in the Southeastern United States. Constructs were assessed using self-report surveys.Results:Participants reported consuming alcohol, on average, 5.6 times over the prior month. Average alcohol consumption was reported to be 7.8 beverages per drinking occasion. Participants reported engaging in heavy drinking an average of 2.9 times over the past 30 days. On average, service members reported a preference for 1.3 drinks before sexual activity. Furthermore, 75.2% of participants preferred to be sober during sex, and 82.1% preferred to engage in sexual activity with a sober partner. Approximately 14% of the sample reported using alcohol to improve their chances of having sex.Conclusion:These findings highlight high rates of alcohol use among soldiers. Nonetheless, young adult male soldiers report a preference for sexual activity while sober. Understanding the co-occurrence of alcohol use and sexual activity has the potential to inform the development of integrated alcohol and sexual assault prevention programs for service members.
Latex Allergy – From Discovery to Component-resolved Diagnosis
Authors: Loverre Teresa , Casella Rossella , Miniello Andrea , Di Bona Danilo , Nettis Eustachio 
Published: September 2023

Abstract:
Latex allergy is a hypersensitivity response to natural rubber latex (NRL) proteins or rubber chemicals used in the manufacture of latex products. An accurate diagnosis is the first step in the effective management of individuals with latex allergy, especially in high-risk groups, such as healthcare workers and those affected by spina bifida. Diagnosis is based on the clinical history and an accurate allergological evaluation. In the case of type I IgE-mediated hypersensitivity reac-tions, which can manifest urticaria, angioedema, rhinoconjunctivitis, asthma and anaphylaxis after latex exposure, skin prick tests or latex-specific IgE (sIgE) antibody detection using serological assays can be performed to confirm sensitization. Instead, in the case of contact dermatitis, a patch test can be applied to confirm the presence of a type IV T cell-mediated hypersensitivity reaction to rubber accelerators or additives. Basophils activation tests or challenge tests may be performed if there’s an incongruity between the clinical history and the results of in vivo and in vitro tests. The aim of this review is to analyze the current state of the art of diagnostic techniques for latex allergy and algorithms employed in clinical practice and possible future developments in this field.
Terpenoids in Diabetic Nephropathy: Advances and Therapeutic
Opportunities
Authors: Kaushik Manish , Kaushik Aditi , Chaudhary Jasmine , Jain Akash 
Published: September 2023

Abstract:
Diabetic nephropathy (DN) is the foremost ailment resulting in end-stage renal damage. Chronic hyperglycaemia and hyperlipidaemia are the foremost reason for disease progression. The dis-ease is characterized by the severity of albuminuria and cardiovascular disorders. Approximately 20 to 40% of the global prevalence of DN is mostly reported to occur in individuals with diabetes, and nearly 28% of DN occurs in individuals with other renal disorders. The pathological mechanism is very com-plex, involving innumerable targets and leading to multiple pharmacological effects. Thus, the scien-tific community is forced to work in search of safe and potent therapeutics that can tackle the complex pathology of DN effectively. The secondary plant metabolites categorized as terpenoids gained atten-tion as potential therapeutics contrary to others for the management of diabetic nephropathy and other associated syndromes by their strong antioxidant activity and inhibition of advanced glycation and its associated products. This review focused on herbal therapeutics for the management of diabetic nephropathy. Moreover, different types of terpenoids, their biological sources, and proposed mecha-nisms of action are explored for the development of a novel pharmacophore for diabetic nephropathy.
An Overview of Metallic Nanoparticles: Classification, Synthesis,
Applications, and their Patents
Authors: Dhir Sarika , Bhatt Shailendra , Chauhan Mahima , Garg Vandana , Dutt Rohit , Verma Ravinder 
Published: September 2023

Background:
Nanotechnology has gained enormous attention in pharmaceutical research.
Nanotechnology is used in the development of nanoparticles with sizes ranging from 1-100 nm, with
several extraordinary features. Metallic nanoparticles (MNPs) are used in various areas, such as molecular
biology, biosensors, bio imaging, biomedical devices, diagnosis, pharmaceuticals, etc., for their specific
applications.

Methodology:
For this study, we have performed a systematic search and screening of the literature and
identified the articles and patents focusing on various physical, chemical, and biological methods for the
synthesis of metal nanoparticles and their pharmaceutical applications.

Results:
A total of 174 references have been included in this present review, of which 23 references for
recent patents were included. Then, 29 papers were shortlisted to describe the advantages, disadvantages,
and physical and chemical methods for their synthesis, and 28 articles were selected to provide
the data for biological methods for the formulation of metal NPs from bacteria, algae, fungi, and
plants with their extensive synthetic procedures. Moreover, 27 articles outlined various clinical applications
of metal NPs due to their antimicrobial and anticancer activities and their use in drug delivery.

Conclusion:
Several reviews are available on the synthesis of metal nanoparticles and their pharmaceutical
applications. However, this review provides updated research data along with the various methods
employed for their development. It also summarizes their various advantages and clinical applications
(anticancer, antimicrobial drug delivery, and many others) for various phytoconstituents. The overview
of earlier patents by several scientists in the arena of metallic nanoparticle preparation and formulation
is also presented. This review will be helpful in increasing the current knowledge and will also inspire
to innovation of nanoparticles for the precise and targeted delivery of phytoconstituents for the treatment
of several diseases.
Comparing the Effectiveness and Safety of Anterior Cervical Discectomy and Fusion with Four Different Fixation Systems: A Systematic Review and Network Meta-analysis
Authors: Xiao Jin , Yu Hui , Sun Jianfeng , Deng Yuxuan , Zhao Yang , Gao Rui , Li Xian 
Published: September 2023

Background:
Anterior cervical discectomy and fusion (ACDF) is the classic procedure for the treatment of degenerative cervical myelopathy (DCM). Cage with plate (CP), polyetheretherketone cage alone (PCA), ROI-C and Zero-P are the most widely used fixation systems in ACDF. However, there is insufficient evidence to determine the optimal system for ACDF.

Purpose:

A comprehensive analysis to show which of the CP, PCA, ROI-C and Zero-P after ACDF has the best clinical efficacy and the most reliable safety.

Methods:
We searched the Embase, Pubmed, and Cochrane library up to the date of February 13th, 2021. Studies included relevant randomized controlled trials (RCTs) and cohort studies with a comparison of different fixation systems among CP, PCA, ROI-C and Zero-P were identified.

Results:
We screened 43 trials eligible, including 3045 patients. No significant differences were found in the NDI score. PCA has shown a significantly less recovery of cervical lordosis than CP and Zero-P. For the non-fusion rate, PCA was significantly higher than CP. PCA had a significantly higher subsidence rate than CP and Zero-P, and ROI-C was also significantly higher than CP. For the incidence of complications, CP was significantly higher than the others. The surface under the cumulative ranking curves (SUCRA) for NDI score improvement was: SSC, PCA, and CP. ROI-C, Zero-P, PCA, and CP; for cervical lordosis recovery: CP, Zero-P, ROI-C, and PCA; for non-fusion rate: PCA, Zero-P, ROI-C, and CP; for subsidence rate: PCA, ROI-C, Zero-P, and CP; for complications: CP, PCA, ROI-C, and Zero-P.

Conclusion:
Despite the third-ranking spectrums of fusion rate, Zero-P still could be recommended for its second-ranking spectrums of the NDI score improvement efficacy, cervical lordosis recovery, and reduction of subsidence rate, with the least ranking of complications.

Registration:
The number of PROSPERO is CRD42021230735 (www.crd.york.ac.uk/PROSPERO).
Investigation into Factors Affecting Penetration Rate and Favorable Ground Types of Pipe Jacking
Authors: Hosny Suad , El-Demerdash Ahmed , El-Kelesh Adel M. 
Published: September 2023

Introduction:
Improper assessment of the penetration rate (PR) of pipe jacking (PJ) may lead to serious schedule delays and cost overruns. In the current practice, PR is estimated on the basis of the experience of practitioners. This has resulted in predicted PR values that are not consistent with the actual ones. A guideline that can be used to reliably predict PR and account for the effects of the significantly controlling factors is not available. This negatively affects the estimated project time and cost. The problems stem from the many factors that affect PR such as the ground conditions, installation depth, machine type, operator experience, and pipe diameter. Little research has been made in this regard. So this research will focus on two main objectives; the first is to identify, categorize and rank the factors that affect PR, and the second is to investigate the common types of ground and PJ machines in Egypt and the Middle East to determine the favorable ground types for PJ machines.

Methods:
To determine the factors that affect the PR of PJ and their relative importance, interviews were made with 17 PJ experts in Egypt. Then, a questionnaire was sent to 149 PJ experts in Egypt and the Middle East. The obtained responses were analyzed and the relative importance of all factors was determined. Based on the interviews with experts and the questionnaire survey, the favorability of ground types for the slurry and auger machines was determined.

Results:
The responses and analysis results of the interviews and questionnaire are weighted using the relative importance method and then ranked. The analysis reveals that 20 factors significantly affect PR. The top 5 factors that affect PR are 'ground type', 'ground condition', 'geotechnical investigation', 'crew/operator experience', and 'pipe lubrication'.

Conclusion:
Among the ten new factors which are introduced in this study, the four factors 'ground type', 'ground settlement', 'bentonite water ratio', and 'feed flow rate' are assessed as significant and ranked as the 1st, 7th, 16th, and 20th most important, respectively. It is also concluded that sand and silty sand are very highly favorable for the slurry machines, while silty clay is very highly favorable for the auger machines.
Mining Roles Based on User Dynamic Operation Logs
Authors: Ma Xiaopu , Qi Qinglei , Zhao Li , Ning Fei , Li He 
Published: September 2023

Background:
If we rely solely on whether to assign permissions together to determine roles, the roles we generate may not necessarily reflect the needs of the system. Therefore, the role generation process can be done based on user-to-permission dynamic relationships, such as user dynamic operation logs, thus providing the motivation for this work.

Methods:
In our paper, we introduce a special generalization process and a frequent set-based analysis method to generate roles based on the particular data type of user dynamic operation logs so that the time factor of permissions used is considered before the process of role generation to generate the roles such also as auth_perms(r)={p_1,p_2,p_3}.

Results:
Our algorithm is less time consuming and generates less roles than traditional algorithm. Furthermore, the roles generated by the algorithm can better describe the real needs of the system and have better interpretability.

Conclusion:
The results show that the algorithm has superior performance and useful role generation compared to traditional algorithm.
INVESTIGATION INTERFACIAL SHEAR STRENGTH AND MECHANICAL PROPERTIS OF ALKALI TREATED HONEY PINEAPPLE FIBER/ MICROCRYSTALLINE CELLULOSE COMPOSITE
Authors: Sakuri Sakuri , Sugiantoro Bambang , Shidiq M. Agus , Hakim Reza Azizul Nasa Al 
Published: September 2023

The research objective was investigate the effect of alkali treatment on thermal stability, interfacial shear strength, mechanical properties and waterabsorption in composite of honey pineapple fiber (HPF). HPF was not given and treated by soaking in a mixture of 6% wt sodium hydroxide. Mixing between Unsaturated Polyester (UPRs) and Microcrystalline Cellulose (MCC) applied the Taguchi test with 5% MCC, 250 RPm, 40 oC temperature, and 30 minutes. The composites were mold using the vacuum infusion method and curing at 60 o C for 120 minutes. Interfacial shear strength test showed 9 hours of immersion, gave strength of 3.49 MPa, an increase of 37.39%. Tensile strength increased by 30.4%,the flexural strength of the composite increased by 51.08%. The results of the SEM test showed the fiber untreated was still smooth and there were several interface gaps. The water absorption test showed that the untreated fiber had a higher absorption rate.
The Critical Naturalism Manifesto: Some Comments
Authors: Radder Hans 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
Critical Naturalism: The Manifesto and Critical Realism
Authors: Lindner Urs 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
The Aesthetics of Natural History
Authors: Heinze Tobias 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
The Need of a Critical Theory of Digitalization (Remark on the Point of Technologization in the Manifesto)
Authors: Colligs Alexandra 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
Is Critical Naturalism Necessary?
Authors: Prange Martine , Van Gemert Ties , Van der Deijl-Kloeg Willem , Santori Paolo 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
"First Nature" and Colonial Rifts: Response to "Critical Naturalism: A Manifesto"
Authors: Leeuwenkamp Jasmijn 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
Feminism after Gaia: Care and the Posthuman
Authors: Van den Heuvel Nathanja 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
Use of the narcotic analgesic fentanyl to correct violations of the autonomic regulation of childbirth
Authors: Zhezher A.O. , Zhezher N.P. 
Published: September 2023

Background. The problem of effective prolonged epidural analgesia (PEA) in case of hypotonic labor, which allows minimal intervention in the process of labor activity while providing adequate analgesia, remains unresolved. A study was conducted to increase the effectiveness of PEA use during the first state of childbirth in women with hypotonic labor. The purpose: to increase the effectiveness of prolonged epidural analgesia in case of hypotonic labor during vaginal childbirth. Materials and methods. We performed analgesia to 60 women with a diagnosis of stage 1 hypotonic labor who were divided in 2 groups: the main one (n = 35) and the controls (n = 25). ASA status in both groups was I–II. In both groups, the epidural space was punctured at L1-L2. A test 4-ml dose of 2% lidocaine solution was administered and 5 minutes after, the epidural catheter was inserted. Then, in the main group, 1 ml of fentanyl solution and 6 ml of 0.9% NaCl were injected into the epidural space; in the control group, 6–8 ml of 0.125% bupivacaine solution. The effectiveness was evaluated according to the visual analogue scale, hemodynamic changes and the outcome of childbirth (conservative or operative). The condition of the fetus was assessed according to cardiotocography data. Statistical processing of the material was carried out using Excel. Results. The use of fentanyl in 69 % of cases allowed finishing the birth conservatively, the condition of the fetus and newborn was considered satisfactory. In the control group, 72 % of births resulted in cesarean section. Indications for surgery were hypotonic labor and fetal distress. Conclusions. The use of the narcotic analgesic fentanyl for prolonged epidural analgesia in hypotonic labor effectively relieves pain and increases the likelihood of conservative childbirth. It is safe for mother, fetus and newborn.
Del terror al exterminio. Un apunte sobre las matanzas de civiles en El Salvador y Guatemala durante la década de 1980
Authors: Vázquez Olivera Mario 
Published: September 2023

En la década de 1980 se desarrollaron de manera paralela sendas campañas de exterminio en El Salvador y Guatemala. Este trabajo ofrece elementos para sostener que los ejércitos de ambos países enfrentaron el desafío de la insurgencia implementando mecanismos semejantes de “contraterror” o guerra sucia y de aniquilación en masa. También es posible afirmar que las dimensiones del exterminio en El Salvador y Guatemala fueron equiparables. En ambos casos el número estimado de personas asesinadas fue equivalente al 1.5 % del total de la población. Pero más allá de estas cifras, se trató de procesos básicamente similares tanto por su sentido estratégico, como por sus patrones de implementación y sus consecuencias fundamentales.