bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defibrillation effectiveness and safety of the shock waveform used in a contemporary wearable cardioverter defibrillator: Results from animal and human studies
Authors: Gleva Marye J. , Sullivan Joseph , Crawford Thomas C. , Walcott Greg , Birgersdotter-Green Ulrika , Branch Kelley R. , Doshi Rahul N. , Kivilaid Kaisa , Brennan Kelly , Rowbotham Ron K. , Gustavson Laura M. , Poole Jeanne E. 
Published: March 2023

IntroductionThe wearable cardioverter defibrillator (WCD) is used to protect patients at risk for sudden cardiac arrest. We examined defibrillation efficacy and safety of a biphasic truncated exponential waveform designed for use in a contemporary WCD in three animal studies and a human study.MethodsAnimal (swine) studies:#1: Efficacy comparison of a 170J BTE waveform (SHOCK A) to a 150J BTE waveform (SHOCK B) that approximates another commercially available waveform. Primary endpoint first shock success rate.#2: Efficacy comparison of the two waveforms at attenuated charge voltages in swine at three prespecified impedances. Primary endpoint first shock success rate.#3: Safety comparison of SHOCK A and SHOCK B in swine. Primary endpoint cardiac biomarker level changes baseline to 6 and 24 hours post-shock.Human Study: Efficacy comparison of SHOCK A to prespecified goal and safety evaluation. Primary endpoint cumulative first and second shock success rate. Safety endpoint adverse events.ResultsAnimal Studies#1: 120 VF episodes in six swine. First shock success rates for SHOCK A and SHOCK B were 100%; SHOCK A non-inferior to SHOCK B (entire 95% CI of rate difference above -10% margin, p < .001).#2: 2,160 VF episodes in thirty-six swine. Attenuated SHOCK A was non-inferior to attenuated SHOCK B at each impedance (entire 95% CI of rate difference above -10% margin, p < .001).#3: Ten swine, five shocked five times each with SHOCK A, five shocked five times each with SHOCK B. No significant difference in troponin I (p = 0.658) or creatine phosphokinase (p = 0.855) changes from baseline between SHOCK A and SHOCK B.Human Study: Thirteen patients, 100% VF conversion rate. Mild skin irritation from adhesive defibrillation pads in three patients.ConclusionsThe BTE waveform effectively and safely terminated induced VF in swine and a small sample in humans.Trial registrationHuman study clinical trial registration:URL:https://clinicaltrials.gov; Unique identifier:NCT04132466.
Artificial pollination and use of growth regulators in atemoya ‘Gefner’ fruits
Authors: Chagas Pollyana Cardoso , Crane Jonathan , Chagas Edvan Alves , Vendrame Wagner , Costa Barbára Nogueira Souza , Neto Aurélio Rubio , Moura Elias Ariel de 
Published: March 2023

The objective was to study the effectiveness of the growth regulator (ANA + GA3) associated or not to the application of adjuvant and artificial pollination in ‘Gefner’ atemoya. The experiment was conducted in the experimental orchard at Florida’s Tropical Research and Education Center. The experimental design was in a randomized block, with 14 treatments, 10 repetitions and 3 flowers per plot. The highest percentages of fixed fruits were obtained with hand pollination – HP and 450 NAA + 1250 GA3 mg L-1 + adjuvant and HP. The use of hand pollination for ‘Gefner’ atemoya tree proved to be the most efficient method so far. Applying growth regulator without artificial pollination produces parthenocarpic fruits, however with high rate of abortions, and small fruits. Growth regulators together with hand pollination produces small and uneven fruits, and cause reduction in the fruits’ titratable acidity. The use of adjuvant caused low fixation and toxicity to fruits, and its use is not recommended.
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish
Authors: Silva Stella Bicalho , Gregório Kemilli Pio , Freitas Renata Maria Pereira de , Destro Ana Luiza Fonseca , Salaro Ana Lúcia , Zuanon Jener Alexandre Sampaio , Gonçalves Reggiani Vilela , Freitas Mariella Bontempo 
Published: March 2023

Synthetic herbicides have been intensively used in weed control, although often involved in environmental contamination, critically affecting non-target species. However, never was investigated the effect of commercial formulation using atrazine on developing juvenile fish exposed for 35 days. Juveniles (Astyanax altiparanae) (n = 600) were assigned to the following ATZ-exposed groups: 0 (CTR-control), 0.56 (ATZ0.56), 1.00 (ATZ1.00), 1.66 (ATZ1.66) and 11.66 (ATZ11.66) μg/L. We found a 36.6% decrease in juvenile survival rate in the ATZ11.66 group compared to control and other groups. Juveniles from ATZ11.66 also showed hyperglycemia and increased cortisol levels. Increased the imbalance oxidative with an increase in malondialdehyde (MDA) and Carbonylated proteins levels markers in muscle, gills, and liver. We also found increased activity of the antioxidant enzymes superoxide dismutase (SOD) in gills and SOD and catalase (CAT) in muscles from ATZ11.66 fish, and increased glutathione S-transferase (GST) activities in the liver from all exposed groups compared to control. The morphological consequences of this were loss of secondary lamella integrity, increased mucus-secreting cells, hyperplasia, and lamellar fusion, as well as increased aneurysms percentage. The liver showed vascular congestion associated with endothelial hyperplasia, steatosis, and a decrease in the nuclei percentage. Our results showed that exposure to a commercial formulation of ATZ at 11.66 μg/L can be causing an imbalance in the oxidative markers and morphological damages and decreased survival in a juvenile Neotropical species of great ecological relevance and commercial interest.
Asymptotic behavior of solutions to the Monge-Ampère equations with slow convergence rate at infinity
Authors: Liu Zixiao , Bao Jiguang 
Published: March 2023

Abstract
We consider the asymptotic behavior of solutions to the Monge-Ampère equations with slow convergence rate at infinity and fulfill previous results under faster convergence rate by Bao et al. [Monge-Ampère equation on exterior domains, Calc. Var PDE. 52 (2015), 39–63]. Different from known results, we obtain the limit of Hessian and/or gradient of solution at infinity relying on the convergence rate. The basic idea is to use a revised level set method, the spherical harmonic expansion, and the iteration method.
Semantic competence and prototypical verbalizations are associated with higher OSCE and global medical degree scores: a multi-theory pilot study on year 6 medical student verbalizations
Authors: Diogo Pedro Grilo , Pereira Vítor Hugo , Papa Frank , van der Vleuten Cees , Durning Steven J. , Sousa Nuno 
Published: March 2023

Abstract

Objectives
The organization of medical knowledge is reflected in language and can be studied from the viewpoints of semantics and prototype theory. The purpose of this study is to analyze student verbalizations during an Objective Structured Clinical Examination (OSCE) and correlate them with test scores and final medical degree (MD) scores. We hypothesize that students whose verbalizations are semantically richer and closer to the disease prototype will show better academic performance.

Methods
We conducted a single-center study during a year 6 (Y6) high-stakes OSCE where one probing intervention was included at the end of the exam to capture students’ reasoning about one of the clinical cases. Verbalizations were transcribed and coded. An assessment panel categorized verbalizations regarding their semantic value (Weak, Good, Strong). Semantic categories and prototypical elements were compared with OSCE, case-based exam and global MD scores.

Results
Students with Semantic ‘Strong’ verbalizations displayed higher OSCE, case-based exam and MD scores, while the use of prototypical elements was associated with higher OSCE and MD scores.

Conclusions
Semantic competence and verbalizations matching the disease prototype may identify students with better organization of medical knowledge. This work provides empirical groundwork for future research on language analysis to support assessment decisions.
Tomorrow I’ll go (a) shopping: on the history of the Expeditionary Go construction and its relation to the absentive
Authors: Fanego Teresa 
Published: March 2023

Abstract
Work on Construction Grammar and Diachronic Construction Grammar has foregrounded the idea that constructions are organized as a network of interconnected form-meaning pairs. This article explores the history of the construction exemplified in the title, henceforth referred to as the Expeditionary Go construction, and its relation both to other members of the small family of English go-constructions and to the prepositional be-progressive (e.g., 1700, They were a hunting). The analysis traces the development of expeditionary go since Old English times and argues that it was a device conveying the Subject’s remoteness from the speaker-oriented deictic centre. This function has remained basically unchanged over the course of the history of English, but the form of expeditionary clauses has been adjusted as a result of profound language-internal and language-external developments; these developments have brought expeditionary clauses and other members of the network of go-constructions, most especially admonitive clauses (Don’t go peeping like that!), closer together.
Extreme Weather Events and Economic Activity: The Case of Low Water Levels on the Rhine River
Authors: Ademmer Martin , Jannsen Nils , Meuchelböck Saskia 
Published: March 2023

Abstract
We make use of historical data on water levels on the Rhine river to analyze the impact of weather-related supply shocks on economic activity in Germany. Our analysis shows that low water levels lead to severe disruptions in inland water transportation and cause a significant and economically meaningful decrease of economic activity. In a month with 30 days of low water, industrial production in Germany declines by about 1 percent, ceteris paribus. Our analysis highlights the importance of extreme weather events for business cycle analysis and contributes to gauging the costs of extreme weather events in advanced economies.
Durability of Hinoki (Chamaecyparis obtusa) stained wood following Anaglyptus subfasciatus infestation
Authors: Morikawa Takuya , Yamasuso Nobuhiro , Ashitani Tatsuya , Takahashi Koetsu 
Published: March 2023

Abstract
The Japanese longhorn beetle, Anaglyptus subfasciatus, infests coniferous trees resulting in stained wood and low-value discolored lumber. In this study, the discolored Hinoki (Chamaecyparis obtusa) wood was analysed by GC-MS for n-hexane extract, and laboratory wood block tests against termite was carried out. Stained wood had anti-termitic resistance similar to normal heartwood, and it had about twice the n-hexane extract by weight than obtained from heartwood. One compound, nerolidol, was characteristically found in the stained wood. The results suggest that the stained wood may have produced some bioactive components due to damage by wood decay organisms.
Numerical analysis of reinforced concrete beams subjected to impact loads
Authors: Alshaarbaf Ihsan A. S. , Mouwainea Enas Mabrook , Said AbdulMuttalib I. 
Published: March 2023

Abstract
Numerical models for impact load assessment are becoming increasingly reliable and accurate in recent years. The processing time duration for such analysis has been decreased to an acceptable level when combined with modern computer hardware. The aim of this study was to represent a simulation technique and to verify the validity of modern software in measuring the response of reinforced concrete beam strengthened by carbon fiber-reinforced polymer (CFRP) sheet subjected to impact loads at the ultimate load ranges. In this investigation, ABAQUS/Explicit Software’s nonlinear finite element modeling had been used. The response of the impact force–time history and the displacement–time history graphs were compared to the existing experimental results. The adopted general-purpose finite element analysis is verified to be capable of simulating and accurately forecasting the impact behavior for structural systems. In addition, a parametric analysis was carried out to gain a better knowledge of the performance of reinforced concrete beams under impact loading. Four parameters had been changed among the analyzed beams such as impact velocity, impact mass, CFRP sheet thickness, and compressive strength of concrete. Generally, it has been found that using a CFRP sheet in strengthening reinforced concrete beams can greatly improve the members’ impact behavior by improving stiffness as well as increasing load-carrying capacities. The enhanced performance characteristics of strengthening beams under impact loads correlate with the applied kinetic energy and CFRP thicknesses. Finally, for beams with high compressive strength, the deflection values were reduced because of the increase in stiffness.
Non-destructive evaluation of soluble solid content in fruits with various skin thicknesses using visible–shortwave near-infrared spectroscopy
Authors: Pratiwi Evia Zunita D. , Pahlawan Muhammad F. R. , Rahmi Diah N. , Amanah Hanim Z. , Masithoh Rudiati E. 
Published: March 2023

Abstract
Visible–shortwave near-infrared spectroscopy has been used for internal quality measurement, but the optical penetration to the thickness of fruit skin becomes a challenge. This research aimed to develop partial least square regression model for the soluble solid content (SSC) measurement of fruits having various skin thicknesses, namely dragon fruit, tomato, guava, sapodilla, and banana. The spectra of each fruit were taken in a reflectance mode over a wavelength range of 400–1,000 nm. The best models obtained from banana and sapodilla yielded determination coefficient of prediction (R
2
p) of 0.88 and 0.90 and root mean square error of prediction (RMSEP) 0.39 and 0.38°Brix, respectively. The banana and sapodilla SSC prediction models should be able to be used carefully in a variety of applications. Tomato and guava had moderately thinner skin but had the lower R
2
p of 0.64 and 0.76 and the RMSEP of 0.17 and 0.26°Brix, respectively. The poorest model was yielded by dragon fruit, which had the thickest skin with the R
2
p of 0.59 and the RMSEP of 0.40°Brix. The model for guava, although having low R
2
p, can still be utilized as a screening criterion and in some other ‘approximate’ applications. However, the SSC prediction model for tomatoes and dragon fruit is not recommended to use and requires additional research. In addition to the effect of skin thickness, other fruit morphological influences the result of this study. Internal structure and seed number influence the reflection optical geometry, which also affects the SSC prediction model.
Coupling between tautomerism and radiationless deactivation in porphycenes
Authors: Waluk Jacek 
Published: March 2023

Abstract
Quantum yields of fluorescence of porphycenes – porphyrin isomers – can vary by orders of magnitude, even for very similar derivatives, such as meso-dimethyl- vs. meso-tetramethylporphycene. In weakly emitting porphycenes the fluorescence intensity strongly depends on viscosity and can be recovered by placing a molecule in a rigid environment. We postulate that the efficient nonradiative deactivation is due to the quantum effect, delocalization of the inner protons. The delocalization, which increases with the strength of intramolecular hydrogen bonds may induce structural changes that lead to distortion from planarity and, as a result, efficient S0 ← S1 internal conversion. The effect seems to be general, as indicated by good correlation between the quantum yield of fluorescence and the distance between H-bonded nitrogen atoms, the latter being a reliable measure of hydrogen bonding strength. Based on the available photophysical and X-ray data, such correlation was found so far for over 20 differently substituted porphycenes.
Metakaolin-based geopolymers filled with volcanic fly ashes: FT-IR, thermal characterization, and antibacterial property
Authors: Blanco Ignazio , D’Angelo Antonio , Viola Veronica , Vertuccio Luigi , Catauro Michelina 
Published: March 2023

Abstract
In countries where volcanic activity is widespread, fly ash (FA) formation can represent both a waste to be disposed of and a resource of inorganic substances that can be utilized. Among the technologies able to incorporate FA, geopolymers (GP) or inorganic aluminosilicate amorphous materials are very suitable for this purpose. In this study, GP are realized using metakaolin (MK), sodium hydroxide solution (NaOH 8 M), sodium silicate solution (Na2SiO3), and FA as filler (20 wt% with respect to MK content). The samples were cured at 25 or 40°C for 24 h and the physicochemical, thermal, and antibacterial properties of this material through the integrity test, weight loss test, Fourier-transform infra-red spectroscopy (FT-IR), thermogravimetric analysis (TGA), and Kirby-Bauer assay were assessed. Integrity and weight loss tests indirectly revealed the stability of the macroscopic 3D networks and that the curing at 40°C led to more stable GP. The shift of the Si–O–T absorption band (from 1,090 cm−1 of the MK to 1,017–1,012 cm−1 of the specimens with and without FA) in FT-IR spectra suggested the occurrence of the geopolymerizazion reactions, while TGA study confirmed the higher stability of samples cured at 40°C (with a mass loss equal to 7–13% at 800°C under nitrogen atmosphere). Finally, the antimicrobial activity shed light on the ability of the synthesized GP with the filler and treated at 40°C to have a great effect against Escherichia coli and Pseudomonas aeruginosa.
Qualitative analysis of nonlinear electrostatic excitations in magnetoplasma with pressure anisotropy
Authors: Khalid Muhammad , Kabir Abdul , Jan Lal Said 
Published: March 2023

Abstract
The nonlinear propagation of ion-acoustic (IA) electrostatic solitary waves (SWs) is investigated in a magnetized electron-ion plasma in the presence of pressure anisotropy. The energy integral equation is derived by employing the Sagdeev approach. The current approach only allows for positive potential nonlinear structures. The effect of relevant plasma parameters on the characteristics of SW structures is investigated. The current study may be significant in space and astrophysical plasma systems.
Batf stabilizes Th17 cell development via impaired Stat5 recruitment of Ets1‐Runx1 complexes
Authors: Pham Duy , Silberger Daniel J , Nguyen Kim N , Gao Min , Weaver Casey T , Hatton Robin D 
Published: March 2023

AbstractAlthough the activator protein‐1 (AP‐1) factor Batf is required for Th17 cell development, its mechanisms of action to underpin the Th17 program are incompletely understood. Here, we find that Batf ensures Th17 cell identity in part by restricting alternative gene programs through its actions to restrain IL‐2 expression and IL‐2‐induced Stat5 activation. This, in turn, limits Stat5‐dependent recruitment of Ets1‐Runx1 factors to Th1‐ and Treg‐cell‐specific gene loci. Thus, in addition to pioneering regulatory elements in Th17‐specific loci, Batf acts indirectly to inhibit the assembly of a Stat5‐Ets1‐Runx1 complex that enhances the transcription of Th1‐ and Treg‐cell‐specific genes. These findings unveil an important role for Stat5‐Ets1‐Runx1 interactions in transcriptional networks that define alternate T cell fates and indicate that Batf plays an indispensable role in both inducing and maintaining the Th17 program through its actions to regulate the competing actions of Stat5‐assembled enhanceosomes that promote Th1‐ and Treg‐cell developmental programs.
Growth and disease burden in children with hypophosphatasia
Authors: Högler Wolfgang , Linglart Agnès , Petryk Anna , Kishnani Priya S , Seefried Lothar , Fang Shona , Rockman-Greenberg Cheryl , Ozono Keiichi , Dahir Kathryn , Martos-Moreno Gabriel Ángel 
Published: March 2023

Objective
Hypophosphatasia, an inborn error of metabolism characterized by impaired bone mineralization, can affect growth. This study evaluated relationships between anthropometric parameters (height, weight, and body mass index) and clinical manifestations of hypophosphatasia in children.

Design
Data from children (aged <18 years) with hypophosphatasia were analyzed from the observational Global Hypophosphatasia Registry.

Methods
Anthropometric parameters were evaluated by age group (<2 years and ≥2 years) at assessment. The frequency of hypophosphatasia manifestations was compared between children with short stature (< percentile) and those with normal stature.

Results
This analysis included 215 children (54.4% girls). Short stature presented in 16.1% of children aged <2 years and 20.4% of those aged ≥2 years at assessment. Among those with available data (n = 62), height was below the target height (mean: −0.66 standard deviations). Substantial worsening of growth (mean delta height z score: −1.45; delta weight z score: −0.68) occurred before 2 years of age, while in those aged ≥2 years, anthropometric trajectories were maintained (delta height z score: 0.08; delta weight z score: 0.13). Broad-ranging hypophosphatasia manifestations (beyond dental) were observed in most children.

Conclusions
Short stature was not a consistent characteristic of children with hypophosphatasia, but growth impairment was observed in those aged <2 years, indicating that hypophosphatasia might affect growth plate activity during infancy. In addition, a broad range of clinical manifestations occurred in those above and below the third percentile for height, suggesting that height alone may not accurately reflect hypophosphatasia disease burden and that weight is less affected than longitudinal growth.
THE INFLUENCE OF PHYSICAL FITNESS OF GIRLS 11-15 YEARS OLD WITH POSTURAL DISORDERS ON THE FORMATION OF MOVEMENT CULTURE
Authors: Vasylchuk Hryhoriy 
Published: March 2023

The article examines the peculiarities of the level of physical fitness of girls aged 11-15 who have postural disorders. A comparative characterization of the indicators of motor readiness of girls with and without postural disorders was also carried out. The influence of motor activity on the formation of correct posture and improvement of physical health was studied. The content of the concept of "posture disorders" was analyzed and it was established that posture is an important comprehensive indicator of the state of health and harmonious physical development of each person. And the correct posture ensures an optimal position and normal activity of internal organs, creating the best conditions for the activity of the entire body. It was determined that the physical fitness indicators of girls with postural disorders are significantly lower than those of their peers without postural disorders. The main reasons that contribute to the development of hypodynamism among schoolchildren, which negatively affects their posture, have been clarified. A reliable difference was established between the level of physical fitness of elementary school students with different posture development. It is emphasized that options for solving this problem are possible due to the intensive use of all means of physical culture. It was concluded that the majority of elementary school students have a sedentary lifestyle, which negatively affects their psycho-emotional and somatic state, and as a result, low and moderate physical fitness is observed. Therefore, this problem requires the search for new ways and methods of prevention and elimination of damaged locomotor apparatus during the child's development, taking into account their physical fitness, mortality, anthropometric, psychological and individual characteristics.
Keywords: physical education, schoolgirls, primary school, posture disorders, physical fitness.