bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of heat transfer mechanism in supercritical fluids from the aspect of pool heating
Authors: Liu Minyun , Liu Shenghui , Xi Dapeng , Huang Shanfang , Huang Yanping 
Published: January 2023

For the special phenomena of heat transfer deterioration or enhancement in supercritical fluid heat transfer, existing research still presents inconsistent opinions. In this study, we perform an analysis of the property changes, and present new understandings for pseudo-boiling theory. More importantly, essential differences between subcritical boiling and supercritical pseudo-boiling are highlighted; the critical factors being thermodynamic instability and stability. For isothermal heating cases, pseudo film boiling can be regarded as an extension of near-critical boiling. Moreover, pseudo nucleate boiling only appears in non-isothermal heating cases and is strongly dependent on the heater geometry, materials, etc. A coupled level-set and volume-of-fluid method is used to simulate the near-critical film boiling of carbon dioxide at pressures of 7.0 and 7.37 MPa. In comparison, supercritical cases at a pressure of 7.5 MPa are the natural convections of single-phase fluid with variable physical properties. The numerical results indicate the similar motions of low-density fluids in subcritical and supercritical cases. All results are consistent with prior experiments, providing a better understanding of the special features of supercritical fluid heat transfer.
A switching control method based on a new model considering parasitic capacitance for LLC
Authors: Han Yetong , Ma Dazhong , An Qingpeng 
Published: January 2023

LLC converters are used for linking renewable energy and smart grids. However, the output is higher than the reference caused by its own characteristics, especially in the light load, and the output is limited. A new control method is proposed in this paper based on a new model considering parasitic capacitance, which plays a vital role in keeping the output constant in the light load conditions and widening the output range. In addition, the definition of the light load is given in this paper, which ensures an accurate control. In the switching process, a transition period is set to avoid the components from being damaged due to sudden switching and ensures a smooth output and the stability of the control. Finally, this control method based on the new model is proved valid on a 400 V-36 V-1 kw prototype.
Genetically determined serum bilirubin level and the risk of heart failure: A mendelian randomization study
Authors: Guan Bo , Yang Mingyan , Shen Xing , Wang Yemei , Liu Yutong , Liu Ruihan , Li Shijun , Cao Jian 
Published: January 2023

Background: The association between serum bilirubin level and heart failure (HF) was controversial in previous observational studies and the causal effects of bilirubin on HF have not been investigated. Here, we conducted a Mendelian randomization (MR) study to investigate the associations between genetically determined bilirubin level and HF.Methods: Summary data on the association of single nucleotide polymorphisms (SNPs) with serum bilirubin levels were obtained from genome-wide association study (GWAS) for individuals of European descent and East Asian descent separately. Statistical data for gene-HF associations were extracted from three databases: the HERMES Consortium (47,309 cases and 930,014 controls), FinnGen study (30,098 cases and 229,612 controls) for European population and Biobank Japan (2,820 HF cases and 192,383 controls) for East Asian population. We applied a two-sample Mendelian randomization framework to investigate the causal association between serum bilirubin and HF.Results: Findings from our MR analyses showed that genetically determined serum bilirubin levels were not causally associated with HF risk in either European or East Asian population (odds ratio [OR] = 1.01 and 95% confidence interval [CI] = .97–1.05 for HERMES Consortium; OR = 1.01 and 95% CI = .98–1.04 for FinnGen Study; OR = .82, 95% CI: .61–1.10 for Biobank Japan). These results remained unchanged using different Mendelian randomization methods and in sensitivity analyses.Conclusion: Our study did not find any evidence to support a causal association between serum bilirubin and HF.
Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls: Kinetics, associated factors, and role of SARS-CoV-2 infection
Authors: Rezahosseini Omid , Hamm Sebastian Rask , Heftdal Line Dam , Pérez-Alós Laura , Møller Dina Leth , Perch Michael , Madsen Johannes Roth , Hald Annemette , Hansen Cecilie Bo , Armenteros Jose Juan Almagro , Pries-Heje Mia Marie , Hasselbalch Rasmus Bo , Fogh Kamille , Frikke-Schmidt Ruth , Hilsted Linda Maria , Sørensen Erik , Ostrowski Sisse Rye , Harboe Zitta Barrella , Iversen Kasper , Bundgaard Henning , Sørensen Søren Schwartz , Rasmussen Allan , Garred Peter , Nielsen Susanne Dam 
Published: January 2023

IntroductionWe investigated humoral and T-cell responses within 12 months after first BNT162b2 vaccine in solid organ transplant (SOT) recipients and controls who had received at least three vaccine doses. Furthermore, we compared the immune response in participants with and without previous SARS-CoV-2 infection.MethodsWe included adult liver, lung, and kidney transplant recipients, and controls were selected from a parallel cohort of healthcare workers.ResultsAt 12th-month, the IgG geometric mean concentrations (GMCs) (P&lt;0.001), IgA GMCs (P=0.003), and median IFN-γ (P&lt;0.001) were lower in SOT recipients than in controls. However, in SOT recipients and controls with previous infection, the neutralizing index was 99%, and the IgG, and IgA responses were comparable. After adjustment, female-sex (aOR: 3.6, P&lt;0.009), kidney (aOR: 7.0, P= 0.008) or lung transplantation (aOR: 7.5, P= 0.014), and use of mycophenolate (aOR: 5.2, P=0.03) were associated with low IgG non response. Age (OR:1.4, P=0.038), time from transplantation to first vaccine (OR: 0.45, P&lt;0.035), and previous SARS-CoV-2 infection (OR: 0.14, P&lt;0.001), were associated with low IgA non response. Diabetes (OR:2.4, P=0.044) was associated with T-cell non response.ConclusionIn conclusion, humoral and T-cell responses were inferior in SOT recipients without previous SARS-CoV-2 infection but comparable to controls in SOT recipients with previous infection.
A diet enriched in omega-3 PUFA and inulin prevents type 1 diabetes by restoring gut barrier integrity and immune homeostasis in NOD mice
Authors: Lo Conte Marta , Antonini Cencicchio Martina , Ulaszewska Marynka , Nobili Angelica , Cosorich Ilaria , Ferrarese Roberto , Massimino Luca , Andolfo Annapaola , Ungaro Federica , Mancini Nicasio , Falcone Marika 
Published: January 2023

IntroductionThe integrity of the gut barrier (GB) is fundamental to regulate the crosstalk between the microbiota and the immune system and to prevent inflammation and autoimmunity at the intestinal level but also in organs distal from the gut such as the pancreatic islets. In support to this idea, we recently demonstrated that breakage of GB integrity leads to activation of islet-reactive T cells and triggers autoimmune Type 1 Diabetes (T1D). In T1D patients as in the NOD mice, the spontaneous model of autoimmune diabetes, there are alterations of the GB that specifically affect structure and composition of the mucus layer; however, it is yet to be determined whether a causal link between breakage of the GB integrity and occurrence of autoimmune T1D exists.MethodsHere we restored GB integrity in the NOD mice through administration of an anti-inflammatory diet (AID- enriched in soluble fiber inulin and omega 3-PUFA) and tested the effect on T1D pathogenesis.ResultsWe found that the AID prevented T1D in NOD mice by restoring GB integrity with increased mucus layer thickness and higher mRNA transcripts of structural (Muc2) and immunoregulatory mucins (Muc1 and Muc3) as well as of tight junction proteins (claudin1). Restoration of GB integrity was linked to reduction of intestinal inflammation (i.e., reduced expression of IL-1β, IL-23 and IL-17 transcripts) and expansion of regulatory T cells (FoxP3+ Treg cells and IL-10+ Tr1 cells) at the expenses of effector Th1/Th17 cells in the intestine, pancreatic lymph nodes (PLN) and intra-islet lymphocytes (IIL) of AID-fed NOD mice. Importantly, the restoration of GB integrity and immune homeostasis were associated with enhanced concentrations of anti-inflammatory metabolites of the ω3/ω6 polyunsaturated fatty acids (PUFA) and arachidonic pathways and modifications of the microbiome profile with increased relative abundance of mucus-modulating bacterial species such as Akkermansia muciniphila and Akkermansia glycaniphila.DiscussionOur data provide evidence that the restoration of GB integrity and intestinal immune homeostasis through administration of a tolerogenic AID that changed the gut microbial and metabolic profiles prevents autoimmune T1D in preclinical models.
Upper thermal limits and risk of mortality of coastal Antarctic ectotherms
Authors: Carter Mauricio J. , García-Huidobro M. Roberto , Aldana Marcela , Rezende Enrico L. , Bozinovic Francisco , Galbán-Malagón Cristóbal , Pulgar José M. 
Published: January 2023

Antarctic marine animals face one of the most extreme thermal environments, characterized by a stable and narrow range of low seawater temperatures. At the same time, the Antarctic marine ecosystems are threatened by accelerated global warming. Determining the upper thermal limits (CTmax) is crucial to project the persistence and distribution areas of the Antarctic marine species. Using thermal death time curves (TDT), we estimated CTmax at different temporal scales from 1 minute to daily and seasonal, the predict vulnerability to the current thermal variation and two potential heatwave scenarios. Our results revealed that CTmax at 1 min are far from the temperature present in the marine intertidal area where our study species, showing Echinoderm species higher CTmax than the Chordata and Arthropods species. Simulations indicated that seasonal thermal variation from the intertidal zone contributed to basal mortality, which increased after considering moderate scenarios of heatwaves (+2°C) in the Shetland Archipelago intertidal zone. Our finding highlighted the relevance of including exposure time explicitly on the CTmax estimates, which deliver closer and more realistic parameters according to the species that may be experiencing in the field.
Pravastatin in preeclampsia: A meta-analysis and systematic review
Authors: Mészáros Balázs , Veres Dániel Sándor , Nagyistók Luca , Somogyi Anikó , Rosta Klára , Herold Zoltán , Kukor Zoltán , Valent Sándor 
Published: January 2023

ObjectiveTo review of the efficacy and safety of pravastatin use for prophylaxis and treatment of preeclampsia.DesignSystematic review and meta-analysis of clinical studies evaluating pravastatin for treatment and/or prophylaxis of preeclampsia.Data collectionTwo independent reviewers systematically searched data from PubMed, Scopus, Web of Science, Cochrane, Embase, and clinicaltrials.gov databases, for studies evaluating pravastatin for prevention of pre-eclampsia.ResultsFourteen studies were identified, including 1,570 pregnant women who received either pravastatin or placebo, published between 2003 and 2022. From these studies, 5 studies were identified for inclusion in the meta-analysis to evaluate the role of pravastatin use prior to 20 weeks of gestation, to prevent pre-eclampsia, Pravastatin treatment reduced the incidence of preeclampsia by 61% and premature birth by 45%. Among the newborns, there was a 45% reduction in intrauterine growth retardation (IUGR) in the treated group, as well as a 77% reduction in those receiving neonatal intensive care unit (NICU) admissions.ConclusionProphylactic treatment with pravastatin appears to reduce risk of developing pre-eclampsia as well as potentially lowering risk of IUGR, preterm birth, and NICU admission in neonates.
Prognostic value of radiomics-based hyperdense middle cerebral artery sign for patients with acute ischemic stroke after thrombectomy strategy
Authors: Li Linna , Li Mingyang , Chen Zhongping , Lu Fei , Zhao Min , Zhang Huimao , Tong Dan 
Published: January 2023

Background and purposeThe purpose of this study was to evaluate the prognostic value of radiomics-based hyperdense middle cerebral artery sign (HMCAS) for patients with acute ischemic stroke (AIS) after mechanical thrombectomy (MT) and to establish prediction models to identify patients who may benefit more from MT.MethodsIn this retrospective study, a total of 102 consecutive patients who presented with HMCAS on non-contrast computed tomography (NCCT) at admission and underwent MT in our hospital between January 2019 and December 2020 were recruited. Among them, 46 experienced favorable outcomes (modified Rankin Scale [mRS] ≤ 2) at 3 months of follow-up. All patients were categorized into two sets, namely, the training set (n = 81) and the test set (n = 21). Radiomics features (RFs) and clinical features (CFs) in the training set were selected by statistical analysis to create models. The models' discriminative ability was quantified using the area under the curve (AUC) and confirmed by decision curve analyses.ResultsThe prediction model established using CFs before MT includes baseline National Institutes of Health Stroke Scale (NIHSS) and neutrophil-to-lymphocyte ratio (NLR) [AUC [95% confidence interval (CI)] = 0.596 (0.312–0.881)]. A total of 1,389 RFs were extracted from each hyperdense territory and 8 RFs were left to build the radiomics model [RM; AUC (95%CI) = 0.798 (0.598–0.998)]. The model using preoperative CFs and RFs showed good performance [AUC (95%CI) = 0.817 (0.625–1.000)]. The models using post-operative CFs alone [AUC (95%CI) = 0.856 (0.685–1.000)] or post-operative CFs with RFs [AUC (95%CI) = 0.894 (0.757–1.000)] also showed good discrimination.ConclusionThe radiomics-based HMCAS might be a promising tool to predict the prognoses of patients with AIS after MT.
Mapping the nutritional value of diets across Europe according to the Nutri-Score front-of-pack label
Authors: Mertens Elly , Peñalvo José L. 
Published: January 2023

BackgroundFront-of-pack labels, such as Nutri-Score, aim to offer clear information on the overall nutritional quality of foods and beverages to consumers, allowing them to make healthier food choices. Using the European Food Safety Authority (EFSA) Comprehensive European Food Consumption Database, the present study aims to map out European food consumption patterns by applying the Nutri-Score as a benchmark for nutritional value.MethodsCountry-specific food consumption data, collected by multiple 24-h dietary recalls or food records available from EFSA, were linked to the Dutch Food Composition Database (NEVO). Foods and beverages consumed by adolescents (10–17 years), adults (18–64 years), and the elderly (65–74 years) were graded following the modified Food Standard Agency Nutrient Profiling System (FSAm-NPS) and classified according to Nutri-Score grading, from A to E. Subsequently, a dietary index score (FSAm-NPS-DI) was calculated for each country-specific diet by age-groups and sex as an energy-weighted mean of the FSAm-NPS score of all foods and beverages consumed, with lower scores for a diet of greater overall nutritional quality.ResultsOn average, the daily energy intake of adults across the European countries studied is distributed in 27.6% of A-, 12.9% of B-, 17% of C-, 30.0% of D-, and 12.5% of E-classified foods and beverages. This energy distribution, according to the Nutri-Score, corresponded to a median FSAm-NPS-DI score of 6.34 (interquartile range: 5.92, 7.19). For both adult males and females, Estonia reported the highest energy share from A-classified products, scoring the lowest on the FSAm-NPS-DI. On the other hand, Latvia reported the highest energy share from E-classified products, along with the highest FSAm-NPS-DI. Females and the elderly group reported, in general, a greater energy share from A- and a lower share from E-classified products, and had the lowest FSAm-NPS-DI scores. No sex-related difference was observed for adolescents whose share of energy was predominantly from A- and D-classified products, such as for adults and the elderly.ConclusionOur analyses leveraging the secondary use of country-specific databases on dietary intakes found considerable variation in the nutritional value of European diets, with an overall agreement across all countries on a modestly healthier dietary profile for the elderly and among females.
Does PD-1 blockade play a decisive role in the pathological complete remission of unresectable MSS, BRAF V600E-mutated metastatic colorectal cancer: A case report
Authors: Tan Li , Li Qing-Shu , Peng Dong , Cheng Yong 
Published: January 2023

BackgroundColorectal cancer (CRC) ranks third in highest incidence among human cancers. With the continuous development of anti-cancer drugs, CRC patients are treated more and more effectively. However, the treatment of patients with unresectable metastatic CRC (mCRC) remains a core point for surgeons worldwide, especially for those with microsatellite stability (MSS) and BRAF V600E mutation, who have been reported to have the worst prognosis.Case descriptionWe report a case of pathological complete remission in a patient with unresectable MSS, BRAF V600E-mutated metastatic rectal cancer after using Vemurafenib and Cetuximab in combination with Camrelizumab.ConclusionsThis case suggested that Vemurafenib and Cetuximab combined with Camrelizumab is effective in the treatment of MSS, BRAF V600E-mutated mCRC. To benefit more patients, further studies need to be completed.
Pediatric surgery and self-reported anxiety in children and their parents: A psychometric analysis of the state-trait operation anxiety (STOA) questionnaire
Authors: Barkmann Claus , Härter Valentina , Trah Julian , Reinshagen Konrad 
Published: January 2023

ObjectiveThe preoperative experience in pediatric surgery can cause significant anxiety for both, children and their parents. To date there is no questionnaire available that assesses the child's self-report or both, the child's and parent's self-reported anxiety. The aim of this study was to perform a psychometric analysis of the State-Trait Operation Anxiety (STOA) which provides this option.MethodsThe data based on a randomized controlled study conducted with n = 90 child-parent dyads. The psychometric analyses were performed using classical test theory, including item statistics, Cronbach's α, factor analysis, and test-retest reliability.ResultsThe statistics of the anxiety items were good overall for both ratings following common guidelines. The item means indicated that the items tended to be rather difficult which reduces the reliability for lower anxiety levels. The given scale structure was confirmed overall for both informants. However, a one-factor structure instead of two factors was found for state anxiety. The internal consistencies and retest reliabilities were good to very good. Follow-up analyses confirmed the sensitivity to change for state anxiety. Child anxiety was hardly correlated with parental anxiety, and age and gender effects were rather small.ConclusionsThe STOA questionnaire is the first psychometrically tested questionnaire specifically for fears of surgery that can be used for self-report among children, adolescents, and their parents. Future studies should collect further evidence of its validity as well as comparative scores for specific patient groups and norm values to increase the utility of the instrument.
Determination of HMGB1 in hepatitis B virus-related acute-on-chronic liver failure patients with acute kidney injury: Early prediction and prognostic implications
Authors: Liu Yu , Yuan Wei , Fang Miao , Guo Hongying , Zhang Xin , Mei Xue , Zhang Yuyi , Ji Longshan , Gao Yating , Wang Jiefei , Qian Zhiping , Li Man , Gao Yueqiu 
Published: January 2023

Background: Acute kidney injury (AKI) is a frequent complication in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and is associated with high rates of mortality. We aimed to estimate serum high mobility group protein 1 (HMGB1) levels in hepatitis B virus-related acute-on-chronic liver failure patients and analyze their clinical value in the development and outcomes of Acute kidney injury.Methods: A total of 251 consecutive patients with hepatitis B virus-related acute-on-chronic liver failure were enrolled in this retrospective study. Using the International Club of Ascites staging criteria of Acute kidney injury, 153 patients developed Acute kidney injury. The clinical data of patients were collected and serum levels of high mobility group protein 1 were measured by ELISA. All patients were followed up until death or for a minimum of 3 months. Early prediction and prognostic implications of high mobility group protein 1 in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure Patients with Acute Kidney Injury were investigated in different cohorts, including a propensity score-matched ACLF cohort.Results: Among all individuals with hepatitis B virus-related acute-on-chronic liver failure, the incidence of Acute kidney injury was 61.0% (153/251). The patients who developed stage 2/3 Acute kidney injury showed the highest high mobility group protein 1 levels, followed by those who developed stage 1 Acute kidney injury, and those without Acute kidney injury showed the lowest high mobility group protein 1 levels. Moreover, high mobility group protein 1 levels were significantly higher in non-survivors than in survivors among hepatitis B virus-related acute-on-chronic liver failure patients with Acute kidney injury. Furthermore, analysis of the area under the receiver operating characteristic curve (AUROC) indicated that serum high mobility group protein 1 levels (pre-matching: AUC = 0.740; post-matching: AUC = 0.661) may be a potential predictive factor for Acute kidney injury development and that high mobility group protein 1 (AUC = 0.727) might be a reliable biomarker for prognosis in patients with Acute kidney injury.Conclusion: In patients with hepatitis B virus-related acute-on-chronic liver failure, Acute kidney injury is universal. Acute kidney injury and its stages negatively influence the 90-day transplant-free mortality rate. Serum high mobility group protein 1 levels can serve as a positive predictor of Acute kidney injury development, and high mobility group protein 1 might also be a prognostic biomarker for Acute kidney injury among hepatitis B virus-related acute-on-chronic liver failure patients.