bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Glukosa Serat Kasar pada Akar dan Daun Eceng Gondok (Eichhornia Crassipes)
Authors: Yuana Hera , Syauqi Ahmad , Ramadhan Majida 
Published: September 2023

Water hyacinth (Eichhornia crassipes) is a plant that contains natural fibers in which there is lignocellulose consisting of lignin, hemicellulose and cellulose. The hydrolysis process can break cellulose and hemicellulose polymers into their constituent sugar monomers. Glucose can be used as an energy source for ruminants. This study aims to determine the crude fiber content in water hyacinth plants and to study the concentration of glucose hydrolyzate in the crude fiber component of water hyacinth. The research method is descriptive quantitative, namely the analysis of substances with the Weende method procedure and glucose test with acid hydrolysis (HCl). It was repeated 6 times consisting of roots and leaves. The results showed that the content of crude fiber and minerals in the roots was 43.8% and in the leaves was 29.4%. at the root of 12.05 mol/kg glucose. The presence of glucose content in water hyacinth crude fiber has the potential as a source of ruminant feed with proper hydrolysis application for feed.
Keywords: Water hyacinth (Eichhornia crassipes), Crude Fiber, Glucose, proximate test and acid hydrolysis
ABSTRAK
Tumbuhan eceng gondok (Eichhornia crassipes) yang dianggap sebagai gulma perairan, dapat tumbuh dengan cepat dan memiliki kemampuan adaptasi yang tinggi sehingga dapat mengganggu ekosistem perairan jika jumlahnya tidak terkendali. Perlu adanya upaya pengedalian salah satunya dengan memanfaatkannya menjadi bahan pakan ternak ruminansia. Tumbuhan eceng gondok (Eichhornia crassipes)merupakan tumbuhan yang mengandung serat alam yang didalamnya terdapat lignoselulosa yang terdiri dari lignin, hemiselulosa dan selulosa. Dengan proses hidrolisis dapat memecahkan polimer selulosa dan hemiselulosa menjadi monomer gulapenyusunnya. Glukosa dapat dijadikan sumber energi bagi ternak ruminansia. Penelitian ini bertujuan untuk mengetahui untuk mengetahui kandungan serat kasar pada tumbuhan eceng gondok dan untuk mempelajari konsentrasi hidrolisat glukosa pada komponen serat kasar eceng gondok. Metode penelitian adalah deskriptif kuantitatif yaitu analisis zat dengan prosedur metode weende dan uji glukosa dengan hidrolisis asam. Analisis data yaitu statistik deskriptif Dilakukan 6 kali ulangan terdiri atas bagian akar dan daun tanpa pengambilan mineralnya.Data hasil uji menunjukan adanya kandunganÂ serat kasar dan mineral pada akar yaitu sebesar 43,8 % dan pada daun sebesar 29,4 %. data hasil uji glukosa menunjukan adanya glukosa dalam serat kasar eceng gondok pada daun sebesar 14,70 mol/kg glukosa dan pada akar 12,05 mol/kg glukosa. Hasil penelitian menunjukan adanya kandungan glukosa dari serat kasar eceng gondok yang berpotensi sebagai sumber pakan ruminansia dengan penerapan hidrolisis yang layak untuk pakan.
Kata kunci: Eceng gondok (Eichhornia crassipes), Serat Kasar, Glukosa, uji proksimat dan hidrolisis asam
La conciencia histórica y literaria en los "Comentarios" de Duque de Estrada
Authors: Mateos Frühbeck Nicolás 
Published: September 2023

En el presente trabajo se analizan los rasgos de ficcionalidad y de no-ficcionalidad que poseen los Comentarios del desengañado de sí mismo de Duque de Estrada. Hasta el momento, la cuestión de la ficción/no-ficción de la autobiografía ha sido un elemento clave para la crítica; sin embargo, las autobiografías militares de los siglos XVI y XVII se fundamentan en un paradigma de lectura diferente, además de supeditarse a una intención que justi2ca la razón de ser de la obra. Por ello, se tratará de analizar la literariedad y la aparente invención de la obra, supeditados a la intención última del autor.
El desmayo en las comedias urbanas de Lope de Vega: causas y remedios
Authors: Verducci Erica 
Published: September 2023

El desmayo puede presentarse en el teatro lopesco como reacci.n espontánea y natural a un hecho especialmente relevante de la acción dramática o simulado para llamar la atención y obtener favores. Un rasgo que se encuentra relacionado principalmente con los personajes femeninos y que merece ser observado no solo en el ámbito de las estrategias para subrayar la volubilidad en la mujer, sino también desde un punto de vista pragm.tico o cient.fico. Partiendo de la lectura de la muy famosa El acero de Madrid, en este artículo se ofrece un comentario de los episodios de desmayo m.s notables en un conjunto de obras de Lope pertenecientes al género de la comedia urbana.
Circe: magia, ciencia y sexualidad dura de la norma en la literatura del Siglo de Oro
Authors: Gómez Jiménez Miguel 
Published: September 2023

El presente artículo aborda el mito de Circe en relación con la magia, la ciencia y la sexualidad fuera de la norma en dos textos de la literatura áurea como son el Jardín de ,ores curiosas (1570) de Antonio de Torquemada y Coloquios matrimoniales (1550) de Pedro de Luján. Tratará de explicar la relación de Circe con la compleja y debatida cuestión de la época en torno a la magia natural como forma de ciencia experimental o como producto de la superstición, así como la manipulación del mito femenino como vehículo didáctico de enseñanza moral y cristiana. En ambos casos, el tratamiento del mito es un recurso literario empleado por los autores para justicar una posición ideológica sesgada que restringe el comportamiento de la mujer no solo en el ámbito de las relaciones sociales, sino en el entorno doméstico ligado al matrimonio.
A dual-binding magnetic immunoassay to predict spontaneous preterm birth
Authors: Sveiven Michael , Gassman Andrew , Rosenberg Joshua , Chan Matthew , Boniface Jay , O’Donoghue Anthony J. , Laurent Louise C. , Hall Drew A. 
Published: September 2023

Complications posed by preterm birth (delivery before 37 weeks of pregnancy) are a leading cause of newborn morbidity and mortality. The previous discovery and validation of an algorithm that includes maternal serum protein biomarkers, sex hormone-binding globulin (SHBG), and insulin-like growth factor-binding protein 4 (IBP4), with clinical factors to predict preterm birth represents an opportunity for the development of a widely accessible point-of-care assay to guide clinical management. Toward this end, we developed SHBG and IBP4 quantification assays for maternal serum using giant magnetoresistive (GMR) sensors and a self-normalizing dual-binding magnetic immunoassay. The assays have a picomolar limit of detections (LOD) with a relatively broad dynamic range that covers the physiological level of the analytes as they change throughout gestation. Measurement of serum from pregnant donors using the GMR assays was highly concordant with those obtained using a clinical mass spectrometry (MS)-based assay for the same protein markers. The MS assay requires capitally intense equipment and highly trained operators with a few days turnaround time, whereas the GMR assays can be performed in minutes on small, inexpensive instruments with minimal personnel training and microfluidic automation. The potential for high sensitivity, accuracy, and speed of the GMR assays, along with low equipment and personnel requirements, make them good candidates for developing point-of-care tests. Rapid turnaround risk assessment for preterm birth would enable patient testing and counseling at the same clinic visit, thereby increasing the timeliness of recommended interventions.
Fluorine removal from sodium tungstate ion exchange effluent by precipitation with addition of lanthanum chloride
Authors: Wan Linsheng , Zhao Lifu , Cao Caifang , Gong Dandan , Zeng Xuepin , Yang Liang 
Published: September 2023

The waste water generated from the sodium tungstate ion exchange process of scheelite hydrometallurgical extraction contains a certain concentration of fluorine ion, which caused environmental pollution and harmed human health. In this study, a new method for removing fluorine from the wastewater by precipitation with addition of lanthanum chloride was proposed. In the process, fluorine was removed by from the solution as insoluble lanthanum fluoride precipitates. To explore the favourable conditions for the formation of lanthanum fluoride, thermodynamic analysis of the La-F-H2O system was conducted. Results show that lanthanum fluoride is stable when the solution pH value is between 1.0 and 10.0, and the lanthanum fluoride is gradually converted into lanthana hydroxide when the pH value is more than 10.0 at 298K. The effects of various parameters on the fluorine removal were studied, and the optimum process parameters were determined. More than 92% of the fluorine can be removed when the concentration of fluorine in the solution ranged from 60 to 400 mg/L, the dosage of lanthanum chloride was 1.3 times of the theoretical amount, the pH value was 8.0 at 60°C for 30 min. After removing fluorine from the solution, the resiual fluorine concentrtion was lower than 10 mg/L, which could meet the requirement of national wastewater discharge.
Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy
Authors: Ojeda-Fernández Luisa , Baviera Marta , Foresta Andreana , Tettamanti Mauro , Zambon Antonella , Macaluso Giulia , Schena Simone , Leoni Olivia , Fortino Ida , Roncaglioni Maria Carla , Parati Gianfranco 
Published: September 2023

BackgroundCOVID-19 has been associated with a higher risk of post-acute complications. Our aim was to analyze and compare post-acute cardiovascular complications of COVID-19 survivors of the first and second/third pandemic waves in Lombardy, in both hospitalized and non-hospitalized COVID-19 patients.Methods and resultsWe included adults aged ≥40 years infected during the first and second/third waves of COVID-19 pandemic. The follow-up initiated 30 days after COVID-19 diagnosis and continued up to 9 months. Hazard ratios (HRs) and 95% confidence intervals (CIs) of the post-acute cardiovascular outcomes were calculated against an inverse probability treatment weighted control group. Subgroup analysis were performed by age classes, sex, previous cardiovascular disease and stratified by COVID-19 hospitalization status to explore the impact of COVID-19 severity on outcomes. Compared to the control group, COVID-19 patients had an increased risk of hospitalization for any cardiovascular complications (HR 1st wave 1.53 95% CI: 1.38–1.69; HR 2nd/3rd wave 1.25 95% CI: 1.19–1.31) and for individual cardiovascular outcomes, although HRs were higher in COVID-19 group from the 1st pandemic wave. The results were confirmed in the subgroup analyses. Of note, the risk for any cardiovascular disease was also evident even among individuals who were not hospitalized during the acute phase of the infection.ConclusionOur results provide evidence that COVID-19 is a risk factor for post-acute cardiovascular complications among different pandemic waves regardless of COVID-19 severity, age, sex and a history of cardiovascular diseases. Care strategies of people with COVID-19 should include cardiac monitoring.
How “basic” is basic digital literacy for older adults? Insights from digital skills instructors
Authors: Vercruyssen Anina , Schirmer Werner , Geerts Nelly , Mortelmans Dimitri 
Published: September 2023

IntroductionWith the continuing advancement of digitalization of everyday life, digital literacy becomes more and more a necessity. As a consequence, those who are digitally illiterate experience digital exclusion, which increasingly equals social exclusion. Older adults are typically less digitally active and also less skilled in digital technologies than younger cohorts. Digital inclusion frameworks by governmental and supra-national organizations, on the one hand, and academic definitions of “digital literacy” or “digital skills”, on the other hand, tend to include a broad set of competencies next to technical understanding, such as cognitive and social-emotional skills. However, we argue the problem that expectations of what digital literacy commonly entails are too high level for older adults with no pre-existing digital experience with computers, internet, smartphones, or tablets. Even what is considered as entry-level, basic digital skills, or foundational skills, can be very demanding for older adults with limited or no prior knowledge of and practice with digital technologies.MethodsTo make our point, we draw on own data from interviews with 26 digital skills instructors who give training to older adults in Belgium (collected between December 2020 and February 2021).ResultsWe provide empirical evidence for the circumstances that even seemingly basic digital skills, such as getting a device started or downloading apps, can be very demanding and anything but trivial for older adults without prior experience. We demonstrate evidence along three interrelated domains: (1) ICT-jargon and terminology; (2) Hardware; (3) Software and Internet. Each of these domains entail hurdles of knowledge and understanding that need to be overcome for these older adults before we can start addressing the higher goals of digital literacy frameworks.DiscussionThe main implication from this article is that even the most basic tenets of digital technology are neither trivial nor simple to grasp for older adults with no or limited prior experience — a point not sufficiently addressed by current frameworks of digital skills/literacy/competence.
Effects of hypertension on subcortical nucleus morphological alternations in patients with type 2 diabetes
Authors: Cui Feng , Ouyang Zhi-Qiang , Zeng Yi-Zhen , Ling Bing-Bing , Shi Li , Zhu Yun , Gu He-Yi , Jiang Wan-Lin , Zhou Ting , Sun Xue-Jin , Han Dan , Lu Yi 
Published: September 2023

ObjectivesType 2 diabetes mellitus(T2DM) and hypertension(HTN) are common comorbidities, and known to affect the brain. However, little is known about the effects of the coexisting HTN on brain in T2DM patients. So we aim to investigate the impact of HTN on the subcortical nucleus morphological alternations in T2DM patients.Materials &amp; methodsThis work was registered by the clinicaltrials.gov (grant number NCT03564431). We recruited a total of 92 participants, comprising 36 only T2DM patients, 28 T2DM patients with HTN(T2DMH) and 28 healthy controls(HCs) in our study. All clinical indicators were assessed and brain image data was collected for each participant. Voxel-based morphometry(VBM), automatic volume and vertex-based shape analyses were used to determine the subcortical nucleus alternations from each participant’s 3D-T1 brain images and evaluate the relationship between the alternations and clinical indicators.ResultsT2DMH patients exhibited volumetric reduction and morphological alterations in thalamus compared to T2DM patients, whereas T2DM patients did not demonstrate any significant subcortical alterations compared to HCs. Furthermore, negative correlations have been found between thalamic alternations and the duration of HTN in T2DMH patients.ConclusionOur results revealed that HTN may exacerbate subcortical nucleus alternations in T2DM patients, which highlighted the importance of HTN management in T2DM patients to prevent further damage to the brain health.
Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo
Authors: Jansen Diahann T. S. L. , de Beijer Monique T. A. , Luijten Robbie J. , Kwappenberg Kitty , Wiekmeijer Anna-Sophia , Kessler Amy L. , Pieterman Roel F. A. , Bouzid Rachid , Krebber Willem-Jan , de Man Robert A. , Melief Cornelis J. M. , Buschow Sonja I. 
Published: September 2023

IntroductionTherapeutic vaccination based on synthetic long peptides (SLP®) containing both CD4+ and CD8+ T cell epitopes is a promising treatment strategy for chronic hepatitis B infection (cHBV).MethodsWe designed SLPs for three HBV proteins, HBcAg and the non-secreted proteins polymerase and X, and investigated their ability to induce T cell responses ex vivo. A set of 17 SLPs was constructed based on viral protein conservation, functionality, predicted and validated binders for prevalent human leukocyte antigen (HLA) supertypes, validated HLA I epitopes, and chemical producibility.ResultsAll 17 SLPs were capable of inducing interferon gamma (IFNɣ) production in samples from four or more donors that had resolved an HBV infection in the past (resolver). Further analysis of the best performing SLPs demonstrated activation of both CD8+ and CD4+ multi-functional T cells in one or more resolver and patient sample(s). When investigating which SLP could activate HBV-specific T cells, the responses could be traced back to different peptides for each patient or resolver.DiscussionThis indicates that a large population of subjects with different HLA types can be covered by selecting a suitable mix of SLPs for therapeutic vaccine design. In conclusion, we designed a set of SLPs capable of inducing multifunctional CD8+ and CD4+ T cells ex vivo that create important components for a novel therapeutic vaccine to cure cHBV.
Palliative care at any stage of amyotrophic lateral sclerosis: a prospective feasibility study
Authors: Zwicker Jocelyn , Smith Ian C. , Rice Jill , Murphy Rebekah , Breiner Ari , McNeely Susan , Duff Maria , Buenger Usha , Zehrt Belinda , Nogo Danica , Watt Christine L. 
Published: September 2023

IntroductionMany patients with amyotrophic lateral sclerosis (ALS) receive palliative care (PC) very late or not at all. The impact of PC on patients with ALS and caregivers has not been quantified. Study goals included (1) measuring the impact of early PC on quality of life and mood of patients/caregivers and (2) describing patient/caregiver satisfaction with PC.MethodsThe study was a non-randomized, prospective feasibility study of patients with ALS being treated at The Ottawa Hospital ALS Clinic and their caregivers. Exclusion criteria were age &lt; 18 years, inability to complete questionnaires, and prior receipt of PC. The ALS Specific Quality of Life-Revised (ALSSQOL-R) questionnaire (patients only) and Hospital Anxiety and Depression Scale (HADS) were completed at regular intervals for up to 2 years. Patients accepting a PC consultation completed a post-PC satisfaction survey. Primary outcome measures included ALSSQOL-R and HADS scores compared before and after PC consultation, and between groups receiving and not receiving a PC consultation. Secondary outcome measures included responses on the post-PC satisfaction survey (1 = strongly disagree, 5 = strongly agree).Results39 patients with ALS (age 66 ± 10 years, median time from diagnosis = 6 months) and 22 caregivers were enrolled. 32 patients had a PC consultation (30 were virtual). Patients and caregivers agreed with statements that the PC consult was helpful (mean ± SD = 4.54 ± 0.60, range = 3–5) and they would recommend PC to others with ALS (4.59 ± 0.59, range = 3–5). Participants disagreed with statements that the consult would have been better later in disease course (1.87 ± 0.80, range = 1–4) and that it took too much time/energy (1.44 ± 0.85, range = 1–4). Average ALSSQOL-R scores worsened significantly over time. HADS and ALSSQOL-R scores did not significantly differ between groups receiving and not receiving PC.ConclusionPatients with ALS and their caregivers found virtual PC consultations beneficial irrespective of disease duration or severity. Offering routine PC to all patients with ALS is feasible and should be considered as part of standard care.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04257760, identifier NCT04257760.
Quantum molecular resonance electrotherapy (Rexon-Eye) for recalcitrant dry eye in an Asian population
Authors: Foo Valencia Hui Xian , Liu Yu-Chi , Tho Bryan , Tong Louis 
Published: September 2023

ObjectivesTo assess the safety, efficacy, patients’ satisfaction and acceptability of Rexon-Eye electrotherapy in treating Asian severe dry eye disease (DED) patients.MethodsProspective parallel-arm pilot study recruiting 40 DED Chinese patients with &gt;moderate recalcitrant DED (Contact Lens Research Unit [CCLRU] &gt; grade 2). Subjects were randomized into 2 groups, undergoing four weekly treatment sessions each: group 1 received full treatment power; group 2 received control treatment (power 1 treatment). Non-invasive tear break-up time (NIBUT), cornea fluorescein staining graded via CCLRU and Schirmer’s I test were compared pre- and 2 months post-treatment. The SPEED and QUEST questionnaires that evaluated subjective symptoms and treatment satisfaction, respectively, at baseline and 2 weeks post-treatment were carried out. Tear cytokine levels in both groups were examined at 2 weeks post-treatment.ResultsThe amount of improvement in post-treatment corneal staining in the inferior corneal zone was significant in Group 1 (p = 0.038) but not in Group 2 (p = 0.832). Group 1 eyes with worse baseline staining (total score &gt;9.8) had a significantly greater reduction of corneal staining than those with better baseline staining (−11.7 ± 1.98 vs. −4.6 ± 2.89, p &lt; 0.001). There were no other significant differences in NIBUT, Schirmer’s 1 and cornea fluorescein staining grading within or between the groups.: Group 1 (n = 24) had improved subjective dryness scores compared to Group 2 (n = 16) (SPEED score: 6.38 + 4.16 vs. 10.0 + 6.36, p = 0.04). No significant differences were seen in 11 tear cytokine levels at 2 weeks post-treatment between the 2 groups.ConclusionIn Asian DED patients treated with Rexon-Eye, inferior cornea staining showed significant improvement compared to placebo, and eyes with greater cornea staining at baseline achieved a greater improvement in staining. There were no other significant improvements in NIBUT and Schirmer’s 1. Rexon-Eye also improved subjective DED scores in 41.7% of eyes without any adverse effects.
Improving brain tumor segmentation with anatomical prior-informed pre-training
Authors: Wang Kang , Li Zeyang , Wang Haoran , Liu Siyu , Pan Mingyuan , Wang Manning , Wang Shuo , Song Zhijian 
Published: September 2023

IntroductionPrecise delineation of glioblastoma in multi-parameter magnetic resonance images is pivotal for neurosurgery and subsequent treatment monitoring. Transformer models have shown promise in brain tumor segmentation, but their efficacy heavily depends on a substantial amount of annotated data. To address the scarcity of annotated data and improve model robustness, self-supervised learning methods using masked autoencoders have been devised. Nevertheless, these methods have not incorporated the anatomical priors of brain structures.MethodsThis study proposed an anatomical prior-informed masking strategy to enhance the pre-training of masked autoencoders, which combines data-driven reconstruction with anatomical knowledge. We investigate the likelihood of tumor presence in various brain structures, and this information is then utilized to guide the masking procedure.ResultsCompared with random masking, our method enables the pre-training to concentrate on regions that are more pertinent to downstream segmentation. Experiments conducted on the BraTS21 dataset demonstrate that our proposed method surpasses the performance of state-of-the-art self-supervised learning techniques. It enhances brain tumor segmentation in terms of both accuracy and data efficiency.DiscussionTailored mechanisms designed to extract valuable information from extensive data could enhance computational efficiency and performance, resulting in increased precision. It's still promising to integrate anatomical priors and vision approaches.