bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial‐Targeting Tannic Cerium Nanocatalyst Attenuates Ischemia/Reperfusion Injury
Authors: Wang Liping , Qiu Shuwen , Li Xi , Zhang Yabing , Huo Minfeng , Shi Jianlin 
Published: June 2023

AbstractIschemic heart disease (IHD) is one of the leading causes of death worldwide. Medications or surgery have been considered as effective protocols to treat IHD for decades. Yet the reperfusion of the blood flow frequently leads to the generation of excessive reactive oxygen species (ROS), causing prominent and irreversible damage to the cardiomyocytes. In the present work, tannic acid‐assembled tetravalent cerium (TA−Ce) nanocatalysts with appealing cardiomyocyte‐targeting and antioxidation capability have been synthesized and applied for the effective and biocompatible ischemia/reperfusion injury therapeutics. TA−Ce nanocatalysts could effectively rescue the cardiomyocytes from oxidative stress induced by H2O2 challenge as well as oxygen‐glucose deprivation in vitro. In the murine ischemia/reperfusion model, cardiac accumulation and intracellular ROS scavenging could be achieved against the pathology, substantially reducing the myocardial infarct area and recovering heart functionality. This work illuminates the design of nanocatalytic metal complexes and their therapeutic prospects in ischemic heart diseases with high effectiveness and biocompatibility, paving the way for the clinical translation from bench to bedside.
Improved Thermal and Chemical Stability of Oxynitride Phosphor from Facile Chemical Synthesis for Vehicle Cornering Lights
Authors: Wen Dawei , Liu Hongmin , Ma Zhe , Zhou Lei , Li Junhao , Guo Yue , Zeng Qingguang , Tanner Peter A. , Wu Mingmei 
Published: June 2023

AbstractOrange Eu2+‐doped phosphors are essential for light‐emitting diodes for cornering lights to prevent fatal road accidents at night, but such phosphors require features of high thermal, chemical stability and facile synthesis. This study reports a series of yellow‐orange‐red emitting SrAl2Si3ON6:Eu2+ oxynitride phosphors, derived from the SrAlSi4N7 nitride iso‐structure by replacing Si4+−N3− with Al3+−O2−. The introduction of a certain amount of oxygen enabled the facile synthesis under atmospheric pressure using the air‐stable raw materials SrCO3, Eu2O3, AlN and Si3N4. SrAl2Si3ON6 has a smaller band gap and lower structure rigidity than SrAlSi4N7 (5.19 eV vs 5.50 eV, Debye temperature 719 K vs 760 K), but exhibits higher thermal stability with 100 % of room temperature intensity remaining at 150 °C compared to 85 % for SrAlSi4N7. Electron paramagnetic resonance, thermoluminescence and density functional theory revealed that the oxygen vacancy electron traps compensated the thermal loss. Additionally, no decrease in emission intensity was found after either being heated at 500 °C for 2 hours or being immersed in water for 20 days, implying both of the thermal and chemical stability of SrAl2Si3ON6:Eu2+ phosphors. The strategy of oxynitride‐introduction from nitride promotes the development of low‐cost thermally and chemically stable luminescent materials.
Assessing the Value of Huddle Implementation in the Perioperative Setting
Authors: Thomas Tina , Hampton Debra , Butler Karen , Hudson Julie L. 
Published: June 2023

ABSTRACTCommunication is essential for safe, effective patient care. In perioperative services, where interdisciplinary teamwork is crucial, communication breakdowns may lead to increased errors, decreased staff member satisfaction, and poor team performance. This process improvement project focused on instituting perioperative huddles for two months and measuring the effect that they had on staff members’ satisfaction, engagement, and communication effectiveness. We used validated, Likert‐style survey tools to gauge participants’ satisfaction, level of engagement, communication practices, and opinions about the value of huddles before and after implementation, in addition to an open‐ended descriptive question in the postsurvey. Sixty‐one participants completed the presurvey and 24 participants completed the postsurvey. Scores across all categories increased post huddle implementation. Benefits of the huddles noted by participants included timely and consistent messaging, sharing essential information, and increased feelings of connection between perioperative leaders and staff members.
Designing poly(vinylidene fluoride) membranes with narrow pore size distribution for microplastics removal from water
Authors: Chen Yuji , Liu Hongxing , Lin Chuner , Cheng Chen , Li Fupeng , Fang Chuanjie , Zhu Liping 
Published: June 2023

AbstractMicroplastics have been recognized as a critical threat to the aquatic ecosystem. Membrane separation technology displays great potential to address this issue, while current commonly‐used polymeric microfiltration membranes fall short of high separation efficiency due to their wide pore distribution. A perfectly simple strategy for homoporous membranes fabrication using commercial poly(vinylidene fluoride) (PVDF) was reported in this work, enabling precise removal of microplastics. In this strategy, hydrophilicity of dope solution was enhanced by adding proper amphiphilic surfactants initially, followed by a novelly‐inserted air exposure progress to gently provide water vapor. Both of the two easy steps induced a surface microscopic phase separation to achieve the growth of homopores. Furthermore, the as‐prepared PVDF membrane displayed high surface porosity and bi‐continuous cross‐section structure. As expected, a high rejection (over 97%) towards 500 nm polystyrene microparticles could be achieved along with satisfying water flux of 662 L m−2 h−1 bar−1, which was superior to most current membranes. This work provides not only a new and facile strategy for preparing homoporous membranes employing commercial polymers rather than rarely‐obtained block polymers, but a promising alternative for the efficient separation of aquatic microplastics.
Factors associating with or predicting more cited or higher quality journal articles: An Annual Review of Information Science and Technology (ARIST) paper
Authors: Kousha Kayvan , Thelwall Mike 
Published: June 2023

AbstractIdentifying factors that associate with more cited or higher quality research may be useful to improve science or to support research evaluation. This article reviews evidence for the existence of such factors in article text and metadata. It also reviews studies attempting to estimate article quality or predict long‐term citation counts using statistical regression or machine learning for journal articles or conference papers. Although the primary focus is on document‐level evidence, the related task of estimating the average quality scores of entire departments from bibliometric information is also considered. The review lists a huge range of factors that associate with higher quality or more cited research in some contexts (fields, years, journals) but the strength and direction of association often depends on the set of papers examined, with little systematic pattern and rarely any cause‐and‐effect evidence. The strongest patterns found include the near universal usefulness of journal citation rates, author numbers, reference properties, and international collaboration in predicting (or associating with) higher citation counts, and the greater usefulness of citation‐related information for predicting article quality in the medical, health and physical sciences than in engineering, social sciences, arts, and humanities.
Cyclic mechanical stretch pre‐stimulated bone marrow mesenchymal stem cells promote the healing of infected bone defect in a mouse model
Authors: Lin Qi , Lin Xi 
Published: June 2023

AbstractCyclic mechanical stretch (CMS) is an effective method to accelerate mesenchymal stem cells (MSCs) differentiation. Here, CMS pre‐stimulated bone marrow MSCs (CMS‐BMSCs) was investigated, characterized and evaluated the therapeutic potential of CMS‐BMSCs on the treatment of infected bone defect in mouse model. BMSCs were obtained from C57BL/6J mice and then subjected to CMS. The osteogenic differentiation capacity of BMSCs was evaluated by alkaline phosphatase (ALP) assay, Alizarin Red staining, qRT‐PCR, and Western blot. The pre‐stimulated BMSCs were transplanted into infected bone defect mice, osteogenesis, antibacterial effects, and inflammatory responses were examined. CMS significantly increased ALP activity and the expression of osteoblastic genes (col1a1, runx2, and bmp7) and enhanced osteogenic differentiation and nrf2 expression of BMSCs. Transplantation of CMS pre‐stimulated BMSCs promoted the healing of infected bone defect in mice, enhanced antibacterial effects, and reduced inflammatory responses in the mid‐sagittal section of the fracture callus. CMS pre‐stimulated BMSCs enhance the healing of infected bone defects in a mouse model, suggesting a potential therapeutic strategy for treating infected bone defects.
Characterization of lipoprotein supplement and influence of its oxidized lipid content on cell culture performance and monoclonal antibody production by a SP2/0 hybridoma cell line
Authors: Moisant Rémy , Cowles Elliott , Broutel Léonie , Deparis Véronique , Baud Anthony , von Hagen Joerg , Kolmar Harald 
Published: June 2023

AbstractA challenging aspect with the use of the Sp2/0 hybridoma cell line in commercial manufacturing processes of recombinant therapeutic proteins is their exogenous lipids requirement for cell proliferation and optimal protein secretion. Lipids are commonly provided to the culture using serum or serum‐derivatives, such as lipoprotein supplement. The batch‐to‐batch variability of these non‐chemically defined raw‐materials is known to impact cell culture process performance. Lipoprotein supplement variability and its impact on fed‐batch production of a recombinant monoclonal antibody (mAb) expressed in Sp2/0 cells were studied using 36 batches from the same vendor. Several batches were associated with early viability drops leading to low process performance during fed‐batch production. Increased caspase‐3 activity (an indicator of apoptosis) was correlated to viability drops when low‐performing batches were used. Addition of an antioxidant to the culture limited the increase in caspase‐3 activity. Physicochemical characterization of batches confirmed that lipoproteins are mainly composed of lipids and proteins; no clear correlation between low‐performing batches and lipoprotein supplement composition was observed. Controlled lipoprotein oxidation leads to lipoprotein solution browning, increasing absorbance at 276 nm and results in poor process performance. Because low‐performing batches absorb more at 276 nm than other batches, oxidized lipids were suspected to be the root cause of low‐performing batches. This study increased the understanding of lipoprotein supplement composition, its sensitivity to oxidation and its impact on process performance.
Learning environments in software testing education: An overview
Authors: Zivkovic Tamara , Draskovic Drazen , Nikolic Bosko 
Published: June 2023

AbstractNowadays, we heavily depend on software, as we utilize it daily. Bugs in the software can cause significant damage, loss of private data and money, and even loss of human lives. Software testing and quality assurance discipline, which belongs to the software engineering domain, aims to ensure that the software is good enough before its release to the market. Therefore, it is vital to ensure that software engineers are highly trained in this domain. Unfortunately, this discipline is frequently neglected throughout software engineering courses. Students are mostly taught just the theoretical principles of software testing and gain little practical experience. Additionally, the software testing lectures are considered to be dull, especially if they are not followed by practical tasks where the students could apply learned techniques and gain hands‐on experience. Several tools, games, and collaborative learning environments have been proposed to make the lectures more interesting and increase student engagement. The main goal of this article is to provide a systematic survey of such environments, where each environment was evaluated in terms of major software testing topics covered and the approach used to engage the students.
A nomogram for predicting the rapid progression of diffuse large B‐cell lymphoma established by combining baseline PET/CT total metabolic tumor volume, lesion diffusion, and TP53 mutations
Authors: Liu Cong , Shi Pengyue , Li Zhenjiang , Li Baosheng , Li Zengjun 
Published: June 2023

AbstractObjectivesThis study aimed to integrate positron emission tomography/computed tomography (PET/CT) metrics and genetic mutations to optimize the risk stratification for diffuse large B‐cell lymphoma (DLBCL) patients.MethodsThe data of 94 primary DLBCL patients with baseline PET/CT examination completed in the Shandong Cancer Hospital and Institute (Jinan, China) were analyzed to establish a training cohort. An independent cohort of 45 DLBCL patients with baseline PET/CT examination from other hospitals was established for external validation. The baseline total metabolic tumor volume (TMTV) and the largest distance between two lesions (Dmax) standardized by patient body surface area (SDmax) were calculated. The pretreatment pathological tissues of all patients were sequenced by a lymphopanel including 43 genes.ResultsThe optimal TMTV cutoff was 285.3 cm3 and the optimal SDmax cutoff was 0.135 m−1. TP53 status was found as an independent predictive factor significantly affecting complete remission (p = 0.001). TMTV, SDmax, and TP53 status were the main factors of the nomogram and could stratify the patients into four distinct subgroups based on their predicted progression‐free survival (PFS). The calibration curve demonstrated satisfactory agreement between the predicted and actual 1‐year PFS of the patients. The receiver operating characteristic curves showed this nomogram based on PET/CT metrics and TP53 mutations had a better predictive ability than the clinic risk scores. Similar results were identified upon external validation.ConclusionsThe nomogram based on imaging factors and TP53 mutations could lead to a more accurate selection of DLBCL patients with rapid progression, to increase tailor therapy.
Category is, supporting BIQTPoC at community colleges: A systematic literature review to aid community college leaders in advocacy
Authors: Gonzalez Ángel de Jesus , Duran Antonio 
Published: June 2023

AbstractIn this chapter, we provide a systematic literature review of current scholarship on BIQTPoC within community colleges. Through a queer of color critique lens, we analyzed literature published over the last three decades. Findings demonstrated a lack of empirical research that perpetuates a gap for community college leader practices to support BIQTPoC.
Cutaneous larva migrans: A case report diagnosed using teledermatology
Authors: Al‐Dhubaibi Mohammed Saleh , Mohammed Ghada F. , Bahaj Saleh Salem , AbdElneam Ahmed Ibrahim 
Published: June 2023

Key Clinical MessageTeledermatology is a branch of dermatology that transmits medical data over several miles using telecommunications technologies. It involves the diagnosis of skin lesions using digital photographs and related patient data, and it can be especially helpful for patients in remote areas who might not have convenient access to dermatologists. Cutaneous larva migrans (CLM) is a zoonotic parasitic disease found in tropical and subtropical areas that are sunny and hot; however, cases of allocated resources have been disclosed in Saudi Arabia. There is little information about the frequency of CLM as a work‐related illness among employees who are exposed to potentially polluted soil or have close contact with pets. In this paper, we present an ancestral case of CLM in Saudi Arabia, explaining the hazards of CLM infection. CLM may pose a challenge for physicians in non‐endemic areas regarding assessment, therapeutic interventions, and protection, especially at work. The holistic strategy to CLM assessment, which includes the participation of numerous science competencies (e.g., veterinarians, dermatologists, and occupational physicians), may contribute to a better understanding of the expansion of human CLM and related risk factors, lowering the chance of infection.
Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site
Authors: Schraw Jeremy M. , Sok Pagna , Desrosiers Tania A. , Janitz Amanda E. , Langlois Peter H. , Canfield Mark A. , Frazier A. Lindsay , Plon Sharon E. , Lupo Philip J. , Poynter Jenny N. 
Published: June 2023

AbstractBackgroundStudies have reported increased rates of birth defects among children with germ cell tumors (GCTs). However, few studies have evaluated associations by sex, type of defect, or tumor characteristics.MethodsBirth defect–GCT associations were evaluated among pediatric patients (N = 552) with GCTs enrolled in the Germ Cell Tumor Epidemiology Study and population‐based controls (N = 6380) without cancer from the Genetic Overlap Between Anomalies and Cancer in Kids Study. The odds ratio (OR) and 95% confidence interval (CI) of GCTs according to birth defects status were estimated by using unconditional logistic regression. All defects were considered collectively and by genetic and chromosomal syndromes and nonsyndromic defects. Stratification was by sex, tumor histology (yolk sac tumor, teratoma, germinoma, and mixed/other), and location (gonadal, extragonadal, and intracranial).ResultsBirth defects and syndromic defects were more common among GCT cases than controls (6.9% vs. 4.0% and 2.7% vs. 0.2%, respectively; both p < .001). In multivariable models, GCT risk was increased among children with birth defects (OR, 1.7; 95% CI, 1.3–2.4) and syndromic defects (OR, 10.4; 95% CI, 4.9–22.1). When stratified by tumor characteristics, birth defects were associated with yolk sac tumors (OR, 2.7; 95% CI, 1.3–5.0) and mixed/other histologies (OR, 2.1; 95% CI, 1.2–3.5) and both gonadal tumors (OR, 1.7; 95% CI, 1.0–2.7) and extragonadal tumors (OR, 3.8; 95% CI, 2.1–6.5). Nonsyndromic defects specifically were not associated with GCTs. In sex‐stratified analyses, associations were observed among males but not females.ConclusionsThese data suggest that males with syndromic birth defects are at an increased risk of pediatric GCTs, whereas males with nonsyndromic defects and females are not at an increased risk.Plain Language Summary

We investigated whether birth defects (such as congenital heart disease or Down syndrome) are linked to childhood germ cell tumors (GCTs), cancers that mainly develop in the ovaries or testes.

We studied different types of birth defects (defects that were caused by chromosome changes such as Down syndrome or Klinefelter syndrome and defects that were not) and different types of GCTs.

Only chromosome changes such as Down syndrome or Klinefelter syndrome were linked to GCTs.

Our study suggests that most children with birth defects are not at an increased risk of GCTs because most birth defects are not caused by chromosome changes.
Light‐induced Photoswitching of 4‐(Phenylazo)benzoic Acid on Au(111)
Authors: Liyanage Chamathka Dehiwala , Ortiz‐Garcia José J. , Struckmeier Annalena , Kienzler Michael , Quardokus Rebecca C. 
Published: June 2023

AbstractPhotochromic molecules can undergo a reversible conversion between two isomeric forms upon exposure to external stimuli such as electromagnetic radiation. A significant physical transformation accompanying the photoisomerization process defines them as photoswitches, with potential applications in various molecular electronic devices. As such, a detailed understanding of the photoisomerization process on surfaces and the influence of the local chemical environment on switching efficiency is essential. Herein, we use scanning tunneling microscopy to observe the photoisomerization of 4‐(phenylazo)benzoic acid (PABA) assembled on Au(111) in kinetically constrained metastable states guided by pulse deposition. Photoswitching is observed at low molecular density and is absent in tight‐packed islands. Furthermore, switching events were noted in PABA molecules coadsorbed in a host octanethiol monolayer, suggesting an influence of the surrounding chemical environment on photoswitching efficiency.
Multi‐species occupancy modeling reveals methodological and environmental effects on eDNA detection of amphibians in temporary ponds
Authors: Peixoto Sara , Mota‐Ferreira Mário , Chaves Cátia , Velo‐Antón Guillermo , Beja Pedro , Egeter Bastian 
Published: June 2023

AbstractAquatic environmental DNA is increasingly used for biodiversity monitoring, such as surveying threatened and invasive species. Mainstreaming these methods in practical applications, however, still requires significant standardization and optimisation, namely regarding DNA capture methods. Here we evaluated how filter type (standard disc filters vs high‐capacity capsules), number of sampling sites, volume of water filtered and environmental factors affected amphibian detection in Mediterranean temporary ponds. The study involved water filtering until clogging at one (capsules) and five (discs) sites from 16 small and shallow ponds, where three urodele and seven anuran species were recorded through sweep‐netting and adult observations. Detection probabilities were estimated from site occupancy models based on replicate sampling and from an adaptation of time‐to‐detection models relating detection probability to volume of water filtered. Discs filtered relatively small volumes (15–1250 mL), with detection probabilities of the two abundant species (Pelobates cultripes, Hyla meridionalis) increasing rapidly with sample size and water volume, reaching almost perfect detection (0.95) at four and seven discs, and 420 mL and 1860 mL, respectively. However, reaching high detection probabilities for rare species (Pelodytes atlanticus, Pleurodeles waltl, Triturus pygmaeus) would require larger sampling effort than that used in our study. Despite filtering much larger volumes (600–5300 mL), filtering with capsules at a single site per pond provided lower detection probabilities for abundant species than filtering with discs at five sites. Rarer species showed no difference between methods, which may be due to small sample sizes and reduced statistical power for species with few detections. The effect of conductivity on species detectability was largely negative, while the influence of water clarity varied across species, and pH had no effects. Overall, our results suggest that eDNA amphibian surveys in Mediterranean temporary ponds need to consider filter clogging, heterogeneous DNA distribution, and highly conductive waters.