bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neosporosis
Authors: Bovine Practitioners American Association of 
Published: March 2023

Neospora caninum is a protozoan parasite that was mistaken for Toxoplasma gondii until the mid-1980's. Although it was first identified in dogs, neosporosis has recently been recognized as a major cause of abortion in cattle, particularly dairy cattle, worldwide.
Full article published in Compendium's Food Animal, Vol 19 ( 4), April 1997
Intussusception in cattle
Authors: Constable P. D. 
Published: March 2023

A hospital-based, case-control epidemiologic study, using medical records of cattle admitted to 17 veterinary medical teaching hospitals in North America and a retrospective case series involving 57 cattle with intussusception admitted to 3 of these teaching hospitals, were used. The objectives were to evaluate selected risk factors and to describe clinical and laboratory findings, surgical management, and postoperative outcome for cattle with intussusception.
Full article published in J Am Vet Med Assoc (1997) 210 531-536
Comparison of three treatments for bovine endometritis
Authors: Sheldon I. M. , Noakes D. E. 
Published: March 2023

Three commercial preparations for the treatment of bovine endometritis were compared: an intrauterine infusion of 1500 mg oxytetracycline hydrochloride solution, an intramuscular injection of 500 μg cloprostenol (a synthetic analogue of prostaglandin F2α), and an intramuscular injection of 3 mg oestradiol benzoate/500 kg estimated bodyweight.
Full article published in Veterinary Record (1998) 142, 575-579.
Fatal marijuana poisoning in cattle
Authors: Driemeier D. 
Published: March 2023

Marijuana, the narcotic produced from Cannabis sativa, is considered a weak poison for animals. Marijuana toxicosis is not rare in dogs that have access to the drug, although many cases probably go unreported because of legal implications. Clinical signs in dogs resemble those seen in humans: odd behaviour, weakness, tremors, incoordination, salivation and nausea.
Full article published in Vet Human Toxicol 1997; 39:351-352.
Conservative and surgical treatment of tibial fractures in cattle
Authors: Martens A. , Steenhaut M. , Gasthuys F. , De Cupere C. , De Moor A. , Verschooten F. 
Published: March 2023

Ninety-five cattle with tibial fractures, all but one with a unilateral fracture, were examined between 1990 and 1994. The feasibility of repairing the fracture was assessed radiographically, also taking into account the bodyweight and value of the animal.
Full article in Veterinary Record (1998) 143, 12-16.
Cattle plague in Shangri-La
Authors: Rossiter P. B. , Hussain M. , Raja R. H. , Moghul W. , Khan Z. , Broadbent D. W. 
Published: March 2023

Between April 1994 and November 1995 the most severe epidemic of rinderpest reported in the world for over a decade affected domestic livestock in the Northern areas of Pakistan.
Full article published in Veterinary Record (1998) 143, 39-42.
outbreak of contagious bovine pleuropneumonia in Ngamiland district of north-western Botswana
Authors: Amanfu W. , Masupu K. V. , Adom E. K. , Raborokgwe M. V. , Bashiruddin J. B. 
Published: March 2023

An outbreak of contagious bovine pleuropneumonia (CBPP) was detected in Botswana in 1995 after more than half a century of freedom from the disease.
Full article published in Veterinary Record (1998) 143, 46-48.
Johne's Control in Cow-Calf Operations
Authors: Collins Mike 
Published: March 2023

The economic impact of Johne's in beef cattle has not been reported. It is largely dependent on the perception of the industry about Johne's disease and this, in turn, is quickly changing. For commercial beef producers, direct economic impacts such as decreased weight gains or decreased fertility are probably minimal. Purebred producers, however, face huge economic problems from Johne's disease. If, in the future, buyers of cattle consider it important to keep Mycobacterium paratuberculosis infections out of their herds, owners of infected herds may find their cattle bringing a lower sale price or are even unsaleable, while those from herds that are test-negative for paratuberculosis or are certified-free of the infection will bring a premium. This economic impact will be driven by buyer perception of the importance of Johne's disease.
Five techniques or critical points for para tuberculosis control will be discussed beginning with the most effective and feasible and ending with the more difficult to implement.
Diagnostic reliability of clinical signs in cows with suspected bovine spongiform encephalopathy
Authors: Braun U. , Schicker E. , Hörnlimann B. 
Published: March 2023

The clinical findings in 50 cows with suspected and subsequently confirmed bovine spongiform encephalopathy (BSE) (group A) were compared with the clinical signs in 22 cows with suspected BSE, but with no histological evidence of the disease (group B).
Full article published in Veterinary Record (1998) 143, 101-105.
New Techniques to Evaluate Functional Impact of Bovine Respiratory Disease
Authors: Coghe J. , Uystepruyest Ch , Bureau F. , Van der Weerdt M. L. , Lekeux P. 
Published: March 2023

Despite prophylactic measures, mainly including vaccination programs and management measures, respiratory disease remains the major cause of economic losses in bovine species. Therapeutic strategies include three targets: the etiologic agents, the inflammatory reaction and the mechanical disorders. Choice of treatment is currently main based on the clinician's personal experience.
A theoretical method has been proposed earlier to classify this syndrome_into four grades of severity: Grade 1, subclinical disease (no treatment); Grade 2, compensated clinical disease (antibiotics only); Grade 3, noncompensated clinical disease (antibiotics + antiinflammatory drugs and Grade 4, irreversible clinical disease (no treatment). However, objective methods to evaluate immediate, in an easy and cheap way, the functional impact of respiratory pathologies and to determine the level of severity are not available.
Three techniques, each one evaluating the oxygen transport chain at a different level, have been studied and validated, i.e. pulse oximetry, lactate dosage and the lobeline test.
Measurement of arterial hemoglobin oxygen saturation is an important means to evaluate effectiveness of the oxygen transport chain. Assessment is usually performed based on an arterial blood sample analyzed by a blood gas analyzer. This technique presents several disadvantages: it's invasive, discontinuous and expensive. Pulse oximetry is a non-invasive, immediate and cheap method of measuring percentage oxygen saturation of arterial hemoglobin, based on differential absorption of red and infrared light. It showed to be useful and accurate in bovines when the probe was fitted to the animal's tail, even with low values of hemoglobin saturation.
Blood lactate levels are elevated in case of severe bovine respiratory disease because of diminished tissue oxygenation and because of elevated respiratory muscle effort. Assessment used to be done by a complex laboratory test. Recently a handportable apparatus, named "Accusport" and measuring blood lactate concentration immediately, has been introduced in equine medicine. It proved also to be reliable and useful in the evaluation of severity of bovine respiratory disease.
Finally, assessment of ventilatory reserve capacity by administration oflobeline, a respiratory analeptic, revealed to be very sensitive and especially valuable in animals with minor respiratory problems.
The theoretical classification into four grades of severity of bovine respiratory disease is worthless without practical means to evaluate functional impact in the field. The three presented tests could help us to realize this objective and finally economize therapeutic strategies in bovine respiratory disease.
The potential of coconut waste as green roof materials to improve stormwater runoff
Authors: Romali Noor Suraya , Ardzu Fatin Afiqah Binti , Suzany Muhamad Nurfaizal 
Published: March 2023

AbstractUrbanization is one of the leading causes of urban flooding as rapid development produces more impervious areas in cities. The application of green roofs is regarded as an effective technology to minimize the adverse effects of urban development. The stormwater management capacities of green roofs have been extensively acknowledged, and they can retain rainfall and detain runoff. Nevertheless, Malaysia has experienced few green roof applications, and only limited literature is available concerning such topics. Additionally, the incorporation of waste and recycled material in green roof designs must be considered to ensure such projects benefit the environment as well as the economy. Therefore, the construction of a green roof utilizing recycled waste materials was attempted. An extensive green roof was constructed using beach morning glory and creeping ox-eye plants as vegetation layers, along with coconut waste, i.e., coconut fiber and coconut shell, as the medium for the filter and drainage layer, respectively. According to the results, the use of recycled coconut waste materials in the green roof operations reduced the peak flow by as much as 86%, while the use of commercial materials led to a reduction of 67%.
Thomasa Reida interpretacja „teorii idei”. Pytanie o bezpośredni przedmiot poznania
Authors: Kucharski Dariusz 
Published: March 2023

Thomas Reid, twórca szkockiej szkoły zdrowego rozsądku, głosił tezę, że wszystkie wcześniejsze systemy filozoficzne obciążone są tym samym „grzechem pierworodnym” – przyjęciem (w różnych formach) reprezentacjonistycznej teorii spostrzeżenia zmysłowego. Nazywał ją „teorią idei”, której konsekwencją miało być oddzielenie podmiotu i przedmiotu poznania nieusuwalną „zasłoną idei”. Konstruowanie własnej filozofii poprzedził analizą historii tego zagadnienia od starożytności do czasów sobie współczesnych, usiłując wykazać zasadność swego stanowiska. Celem artykułu jest odpowiedź na pytanie o trafność poglądów Reida, wyrażonych w przyjmowanej teorii spostrzeżenia. Chodzi więc przede wszystkim o pogląd charakterystyczny dla tradycji arystotelesowsko-tomistycznej, tradycyjnie interpretowany jako prezentacjonizm, oraz poglądy Kartezjusza dotyczące statusu „idei” w procesie poznawania tzw. świata zewnętrznego. Przeprowadzone analizy wskazują jednocześnie na uproszczenia w Reidowskiej interpretacji poglądów jego poprzedników na naturę spostrzeżenia oraz na cechy krytykowanych teorii, które w pewnym stopniu usprawiedliwiają tę krytykę.
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Zgłoszono: 28/10/2022. Zrecenzowano: 24/11/2022. Zaakceptowano do publikacji: 16/12/2022.
MUM1L1 as a Tumor Suppressor and Potential Biomarker in Ovarian
Cancer: Evidence from Bioinformatics Analysis and Basic Experiments
Authors: Zhang Lu , Wu Xue , Fan Xue , Ai Hao 
Published: March 2023

Background:
Ovarian cancer (OC) is the most prevalent gynecologic malignancy, with
high mortality rates. However, its pathogenesis remains unclear. The current study aimed to explore
potential biomarkers and suppressor genes for diagnosing and treating OC.

Methods:
Biochemical and bioinformatics approaches were used to detect differentially expressed
genes (DEGs) in ovarian tissues via integration analysis. Kaplan-Meier plot analysis was performed
to assess progression-free survival and overall survival according to DEGs. Then, we constructed
a protein-protein interaction (PPI) network based on data from the STRING database to
identify the related target genes of DEGs. Finally, DEGs regulating the proliferation, migration,
and invasion of SKOV3 cell lines were validated via in vitro experiments.

Results:
Four DEGs (MUM1L1, KLHDC8A, CRYGD, and GREB1) with enriched expression in
ovarian tissues were explicitly expressed in the ovary based on an analysis of all human proteins.
MUM1L1 had high specificity, and its expression was higher in normal ovarian tissues than in OC
tissues. Kaplan-Meier plot analysis showed that a high MUM1L1 expression was associated with
longer progression-free survival and overall survival in OC. Based on the PPI analysis results,
CBLN4, CBLN1, PTH2R, TMEM255B, and COL23A1 were associated with MUM1L1. In vitro
studies revealed that MUM1L1 overexpression decreased the proliferation, migration, and invasion
ability of SKOV3 cell lines. Meanwhile, MUM1L1 knockdown had contrasting results.

Conclusion:
MUM1L1 is a tumor suppressor gene and is a potential biomarker for diagnosing and
treating OC.
Effect of a Training Intervention Based on the Theory of Planned Behavior on the Pregnancy Intention in Women with One Child: A Training Trial
Authors: Moghadam Masoumeh Farshid , Khorsandi Mahboobeh , Khalajinia Zohreh , Zamanian Maryam , Klobas Jane Elizabeth 
Published: March 2023

Background:Having an only child has positive and negative consequences for the health of the child, mother, and family. However, when one-child families become the norm, the risks of negative long-term impacts increase. In Iran, couples now prefer to have one child. This paper reports on an investigation into the effectiveness of training based on the theory of planned behavior (TPB) on the pregnancy intention in women with one child.Methods:The trial was conducted in 2019 with 102 women with one child, who was supported by the Health Centers in Qom, Iran. They were randomly divided into two groups: TPB theory-based training (n=52) and control (routine healthcare training, n=50) groups. ANCOVA was used to compare the groups' post-training pregnancy intention and its theoretical antecedents.Results:Three months post-training, participants in the TPB group had higher pregnancy intention (η2 = .4, P<0.001), attitude to having a second child (η2 = .41, P<0.001), subjective (perceived) norm for having a second child (η2 = .08, P<0.004), and perceived control for having a second child (η2 = .35, P<0.001). The TPB-based training intervention increased women's awareness of the consequences of having an only child significantly more than routine training (P<0.001).Conclusion:Health center training can increase women's intention to have a second child. In this trial, theory-based training resulted in stronger pregnancy intention than participation in routine training. As health centers in Iran update their programs, this trial highlights the value of course design based on established theory.
Bioactive Phytochemicals and Molecular Mechanisms of Artemisiae
capillariae against Drug Induced Liver Injury based on Network
Pharmacology
Authors: Shan Wen , Yang Zhiping , Zhao Yan , Hu Yan , Yan Ran , Wu Xi , Huang Junzi , Lin Musen 
Published: March 2023

Background:
Artemisiae capillariae (Yinchen, YC) is a well-known herbal medicine used to treat drug-induced liver diseases, while the bioactive phytochemicals and pharmacological targets of YC remain unclear.

Objective:
The study aimed to probe the key active components in YC and determine the potential molecular mechanisms of YC protect against DILI

Method:
In this study, we first delved into the active chemicals and targets of YC, identified potential anti-AILI targets for YC, mapped the components-targets network, performed protein-protein interaction (PPI) analysis, gene ontology (GO) enrichment, and Kyoto encyclopedia of genes and genomes (KEGG) signaling pathway analyses of the action targets. This led to figure out the liver protective mechanism of YC against AILI. Analyzing the molecular docking of key targets, binding domain of ingredients and targets reveals the effective interaction, and the binding energy explains the efficiency and stability of the interactions.

Results:
Network analysis identified 53 components in YC; by systematic screening 13 compounds were selected, which were associated with 123 AILI-related genes. The core ingredients were quercetin, capillarisin and Skrofulein, and the identified crucial genes were AKT1, TNF, and IL6. The GO and KEGG pathway enrichment analysis results indicated that the anti-AILI targets of YC mainly take a part in the regulation of oxidative stress and immune, with related signaling pathways including PI3K/AKT and IL17. Furthermore, the binding pockets of YC bioactive ingredients and key targets were revealed, and the binding ability was proved by molecular docking analysis.

Conclusion:
This study has revealed the potential bioactive molecules and mechanism of YC in AILI and provided a possible strategy for the identification of active phytochemicals against drug-induced liver injury.
MiR-12200-5p Targets Multiple Members of Wnt Signaling Pathway to
Inhibit Osteoblast Differentiation and Bone Formation
Authors: Li Hui , Yin Chong , Li Jingjia , Huang Qian , Huai Ying , Chu Xiaohua , Ji Mili , Tian Ye , Qian Airong , Li Danming 
Published: March 2023

Background:
Osteoporosis is widespread and has become an emerging problem in the elderly. MicroRNAs could affect osteoblast differentiation and further regulate the occurrence of osteoporosis by targeting osteogenic differentiation signaling pathways. Our screening study found that miR-12200-5p simultaneously targeted six important factors within the Wnt signaling pathway (Apc, Tcf4, Tcf7, Wnt3a, Wnt5a, and Lrp6), indicating that miR-12200-5p might function as a strong regulator of this pathway. Since the Wnt pathway exists as one of the most essential pathways for osteogenic differentiation, miR-12200-5p may have an important role in the development of osteoporosis.

Objective:
This study intended to explore the regulatory role and corresponding mechanism of miR-12200-5p in osteoblast differentiation

Methods:
We investigated the differentiation of osteoblast after the treatments of miR-12200-5p mimic and inhibitor. The interactions between miR-12200-5p and its target genes were also detected. Furthermore, the rescue effect of miR-12200-5p inhibitor on osteoporosis was evaluated using an ovariectomized osteoporosis mouse model.

Results:
MiR-12200-5p significantly inhibited osteoblast differentiation, and bound with the 3’-UTR sequences of its target genes (Apc, Tcf4, Tcf7, Wnt3a, Wnt5a, and Lrp6) to reduce the expressions of these genes. The inhibition of miR-12200-5p would almost fully alleviate postmenopausal osteoporosis.

Conclusion:
MiR-12200-5p could strongly repress osteoblast differentiation and bone formation by targeting multiple members of the Wnt signaling pathway simultaneously. The study supplemented the theoretical and experimental basis for researching the mechanism of osteogenic differentiation and inspired the development of novel therapeutic strategies for osteoporosis.
Design and Analysis of a Breast Biopsy Robot Based on TRIZ Theory
Authors: Du Haiyan , Liu Hongle 
Published: March 2023

Background:
In recent years, more and more medical robots have formally stepped into clinical applications and are gradually being accepted by patients. Magnetic resonance image (MRI)-guided breast intervention robot is the most advanced technology for breast cancer treatment. Still, the very limited working space within the MRI scanner restricts the development of breast intervention robots.

Objective:
In this paper, a compact breast biopsy robot in MRI environment is proposed based on TRIZ theory.

Methods:
The structure of the robot is optimized by using the curvilinear principle and the asymmetry principle of TRIZ theory to obtain a modified cartesian coordinates robot for breast biopsy. The coordinate systems of the robot are established using D-H method. Next, 3D visualization simulation of the robot is performed by SimMechanics of MATLAB, and then kinematic simulation and workspace simulation analysis are carried out.

Results:
The simulation results show that motion space of the end effector of the robot meets the requirements of breast intervention surgery, and the robot structure is simple and effective.

Conclusion:
In this paper, a compact breast biopsy robot in MRI environment is proposed. Through the Simulink module of MATLAB to analyze its workspace, it is obtained that its working range is 250mm × 300mm × 200mm, which can cover any position in breast tissue. At the same time, the simulation results of the workspace also show that the structure optimization of the breast biopsy robot based on TRIZ theory is reasonable.
Assessment Methods for Various Hepatotoxicities and their Experimental Models: A Review
Authors: Upadhyay Prabhat Kumar , Singh Sonia , Semwal Bhupesh Chander , Vishwakarma Vishal Kumar 
Published: March 2023

Abstract:Globally, liver diseases are a significant public health concern, necessitating the development of new chemicals that can aid in their treatment or prevention. As a result, scientists have been looking for natural and artificial compounds with hepatoprotective effects. The key objective of this manuscript is to provide details on several techniques and models for determining liver toxicity. The data has been collected for the manuscript from various e-sources such as Publons, Pubmed, Scopus, ScienceDirect, and Web of Science. The development of novel pharmaceuticals involve several steps, beginning with identifying the pharmacological effects in cellular and animal models and concluding with demonstrating their safety and efficacy in humans. The scientific literature mentions several in vitro, ex vivo, and in vivo experimental paradigms for evaluating hepatoprotective drugs. This review's main objective is to outline the key traits, advantages, and disadvantages of each model, as well as the most commonly used hepatotoxic substances (acetaminophen, t-BuOOH, d-galactosamine, ethanol, thioacetamide), biochemical parameters helpful in assessing liver damage in various models, and the most frequently used hepatotoxic substances overall.
Drugs Designed for Degradation in the Environment Post Use
Authors: Sydnes Magne Olav 
Published: March 2023

Abstract:
Accumulation of pharmaceuticals in the environment due to slow mineralization in nature is a
growing pollution problem affecting organisms and animals and humans in the long run. When pharmaceuticals
are antibiotics, the problem is twofold since the buildup of such compounds in the environment
also fuels the development of antibiotic resistance. Building weak structures of biologically active compounds
is one way of facilitating the quicker degradation of the drug in the environment after the drug has
been excreted from the patient subsequently performing its function. The emergence of the process of
photodegradation post-excretion of the pharmaceutical from the patient is one method that is under development,
which will facilitate a quicker breakdown of the drug. Another method to enable this is hydrolysis,
which is pH-dependent and involves making up of compounds that hydrolyze quicker under certain
pH conditions. To enable the ongoing efforts in making pharmaceuticals to be more benign, this focused
review showcases examples from research on antimicrobial agents and anticancer agents.