bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the Application of Biofertilizer Goatish as a Biostimulant on Germination Canavalia Ensiformis L.
Authors: Monteiro Shirley Santos , Marini Fillipe Silveira , Santos Dualyson da Silva , Monteiro Shênia Santos , De Lima Juliana Ferreira , De Lima Leopoldo Oliveira 
Published: March 2023

Objective: This study aimed to evaluate the influence of different concentrations of goatish biofertilizer as an alternative biostimulant on the germination and vigor of pork bean seeds.

Theoretical framework: The availability of complementary nutrients via seeds promotes germination and vigor, since they are fundamental factors for the good development of production. Therefore, the use of alternative technologies as a biostimulant promote better formation and development of the plant.

Methodology: The research was carried out at the Seed Technology Laboratory of the Federal University of Paraíba. A completely randomized design was used, with treatments at different concentrations of goat biofertilizer, namely: 0% (control), 25%, 50%, 75% and 100%, where they were immersed for 10 minutes. The substrate used was Germiteste paper, where 30 jack bean seeds were distributed and stored at a temperature of 30 °C for 12 hours of light. The variables analyzed were: germination speed index, germination, primary root length, hypocotyl length, width and length of cotyledons and green and dry mass of the variables mentioned above.

Results and conclusion: The application of the concentration of 50 and 75% proved to be efficient in the seed germination process and germination speed index. The 25% concentration of goat biofertilizer provided better performance in the morphological characteristics of jack bean seeds.

Research implications: The main contributions of the study are in the sense of demonstrating a different methodology as an alternative biostimulant in the germination and vigor of seeds, which can contribute to researchers and family farmers in overcoming seed dormancy, as well as increasing plant growth and development.

Originality/value: This study proposes to evaluate the biofertilizer as a biostimulant in the germination and vigor of jack bean seeds as an alternative for taking advantage of the organic residue.
Analysis of Implementation of an AGV in Agribusiness Company
Authors: Maciel Higor , Catapan Márcio Fontana , Marques Alessandro 
Published: March 2023

Objective: This paper presents a case study, in a large agricultural machinery assembler, where a method is proposed to ensure an analysis, implementation and validation of the implementation of AGVs in the agribusiness industry.

Theoretical framework: The use of AGVs in the agribusiness industry provides several operational benefits, which are reflected in the optimization of its processes. Thus, becoming more competitive, reconciling new trends and market demands, providing margins of error and increasingly narrow quality standards.

Improvement of product quality: When it comes to car dealerships and their after-sales services, customer satisfaction and/or complaints, there is a scarcity in the literature that reinforce the use of the process mining technique. Thus, to cover this gap, there is a clear need for this research.

Methodology/approach: Using practices from the Lean Manufacturing philosophy, strategies were defined on how to reduce these losses, replacing idle labor with autonomous vehicles.

Results: Results demonstrate significant gains in a low payback time of 45 days and a 22% reduction in operating costs.

Research, practical and social implications: Based on the studies presented in this document, it is possible to verify a considerable loss of labor, due to operator idleness and its resources, such as the transporter cart, as well as layout restrictions and supply models.

Originality: Industry 4.0, also called the Fourth Industrial Revolution, brings technologies to the manufacturing environment. One of them is the use of self-guided vehicles - AGV - to ensure greater agility, dynamism and organization in the operation in an industrial environment.
Challenges and Facilitating Factors to Implement Water Safety Plans: a Systematic Review
Authors: Baracho Rafaella Oliveira , Scalize Paulo Sérgio 
Published: March 2023

Purpose: We aim to identify the factors that facilitated or difficult the implementation of Water Safety Plans (WSP) worldwide.

Method: Systematic survey at Web of Science and Scopus database. The final analysis of the papers involved the extraction and analysis of the metadata, with the aid of the software R, spreadsheets and iramuteq 0.7 alpha 2.

Results and conclusion: The main challenges to implement safety plans are teamwork, timeframe management, documentation and registration of information, financial issues, understanding the importance of the WSP and lack of commitment of high-level directors. The factors that facilitate WSP implementation are teamwork, adaptation to local reality, existence of previous conditions and plans already implemented, financial support and positive commitment of high-level directors. Some factors may affect the implementation of WSP positively or negatively, such as financial issues; the support of high-level directors to implement the project; and similar practices and plans already in execution. The most cited direct benefits of the implementation of WSP were safer water; improvement in the registration of information; improvement in team communication; more efficient and active management of the services; and increase in the team’s self-confidence.

Research implications: The planning and preparation steps of WSP must include strategies to overcome the main challenges. Some factors may affect the implementation of WSP positively or negatively, such as financial issues; the support of high-level directors to implement the project; and similar practices and plans already in execution.

Originality/value: This paper contributes with a general overview of the challenges and facilitators in the WSP examples available in scientific papers, which may help future success implementation of WSP and to avoid usual mistakes in this plan.
Fundamentos epistemológicos do Movimento Santa Catarina pela Educação: desvelando os pressupostos da formação para o século XXI
Authors: Spricigo Fabrício , Martins Filho Lourival José 
Published: March 2023

O estudo, de natureza documental e bibliográfica, vincula-se à discussão entre Políticas Educacionais e Formação Docente. Busca conhecer os fundamentos epistemológicos do Movimento Santa Catarina pela Educação, que congrega um conjunto de ações sob a liderança das principais associações empresariais catarinenses. Aborda o alicerce filosófico-científico que dá sustentação ao movimento. Para captar sua base epistemológica, utiliza como metodologia a seleção e análise (ancorada no método dialético) dos principais materiais disponibilizados no site do movimento até o ano de 2021. As categorias que emergem da pesquisa são: Sociedade da Informação e do Conhecimento, Teoria do Capital Humano, Competência e Neurociência. Conclui-se que a formação educativa no âmbito do movimento é emblemática para adequar a sociedade aos novos parâmetros civilizatórios. Nesse contexto, a educação submetida ao mercado adquire centralidade no que se refere à escolarização no século XXI, especialmente para a adaptação de indivíduos ajustados ao mundo do trabalho flexível.
Assessment on mineral composition: Rice-based composite flour and its baked products in Calabar, Nigeria
Authors: Bassey Stella Oyom , Nchor Onor-obasi A. , Ime Grace Ekpo , Eteng Ofem Effiom , Eteng Mbeh Ubana 
Published: March 2023

Objectives:
Staple food to mobilize micronutrients as well as agricultural effects to improve food availability, affordability, and accessibility, in the utilization of food to address nutrient deficiencies and other nutritional challenges. This study will explore strategies and mechanisms for assessing the mineral composition of rice-based composite flour produced from blends of rice, soybean, coconut, water-yam, and sweet potato flours.

Material and Methods:
Different blends of the composite flours will be prepared as A, B, C, etc. The mineral composition of the rice-based composite flour and its cookies was determined by the spectrophotometric method (applicable to Na, Fe, Ca, K, and Mg).

Results:
The mineral contents of the composite flour samples analyzed in the present study ranged between 30.47 ± 1.41 and 82.00 ± 0.57, 0.24 ± 0.02 and 1.27 ± 0.07, 17.37 ± 0.46 and 87.97 ± 0.24, 104.27 ± 0.54 and 701.63 ± 1.32, and 12.17 ± 78.00 and 78.00 ± 0.67 mg/100 g for sodium (Sa), iron (Fe), calcium (Ca), potassium (K), and magnesium (Mg), respectively, while the mineral contents of the rice-based composite cookie samples analyzed ranged between 170.67 ± 8.45 and 383.33 ± 4.10, 1.07 ± 0.01 and 2.75 ± 0.02, 45.77 ± 0.78 and 64.73 ± 2.17, 113.97 ± 1.46 and 144.23 ± 0.52, and 27.77 ± 0.35 and 74.73 ± 1.73 mg/100 g for Na, Fe, Ca, K, and Mg, respectively. There was a significant difference (P < 0.05) in the mineral composition of the samples.

Conclusion:
The finding of this study is a wake-up alert for policymakers to improve and increase availability, accessibility in the utilization of food to address nutrient deficiencies and other nutritional challenges in the country.
Mosquito Fauna in the Mangroves of Yucatan, Mexico, and Identification of Alphavirus RNA
Authors: Garcia-Rejon Julian E. , Tzuc-Dzul Julio C. , Lopez-Carrillo Karen Y. , Cigarroa-Toledo Nohemi , Cetina-Trejo Rosa C. , Chi-Chim Wilbert A. , Talavera-Aguilar Lourdes G. , Lopez-Apodaca Laura I. , Baak-Baak Carlos M. 
Published: March 2023

ABSTRACT
The surveillance of arboviruses in mangrove mosquitoes is a neglected topic in Mexico. The Yucatan State is part of a peninsula and, therefore, is rich in mangroves along its coast. The purpose of the study was to identify alphavirus in the mosquito fauna of mangroves. Mosquitoes were captured in mangrove settings in seven communities in Yucatan between June 2019 and August 2021. From 1900 to 2200 h and from 0500 to 0800 h, mosquitoes were captured with a backpack-mounted aspirator. In total, 3,167 female mosquitoes of five genera and nine species were captured. Aedes taeniorhynchus and Anopheles crucians were the most abundant mosquitoes collected. Mosquitoes were sorted into 210 pools and tested by reverse transcription-polymerase chain reaction for alphavirus ribonucleic acid (RNA). Alphavirus RNA was found in Ae. taeniorhynchus, An. pseudopunctipennis, and An. crucians collected in the Celestun Mangrove. The community is part of the Ria Celestun Biosphere Reserve, and the presence arbovirus-infected mosquitoes could pose a health risk to residents and visitors alike in the area.
Ezekiel 40–48 as a Model for Bar Kokhba’s Title “Nasi Israel”?
Authors: Bourgel Jonathan 
Published: March 2023

Abstract
Nasi Israel was the official title of Shimon Bar Kosiba (Bar Kokhba), the leader of the second Jewish revolt against Rome (132–135/6 CE). The choice of this designation raises important issues pertaining to the way in which Bar Kosiba conceived his role as leader, the extent of his powers and, more generally, the ideological foundations of his regime. It has often been argued that Bar Kosiba’s model of nasi derives from the prophet Ezekiel’s depiction of the ideal Davidic nasi and that, as such, it has a messianic overtone. This article puts forward a slightly different model. It proposes that nasi Israel refers to a figure distinct from the Davidic nasi, which is derived from an interpretation of Ezekiel’s vision of the restored Temple (Ezek 40–48). This title functioned as a programmatic declaration signaling Bar Kosiba’s main objective to rebuild the Temple and renew the sacrificial worship.
Toxicological characteristics of a new drug Express Uspokoin® tablets for situational correction of behavioral abnormalities in cats and dogs
Authors: Orobec Vladimir , Beloglazov Denis , Mukaseev Sergey , Zeynalov Orhan 
Published: March 2023

Trazodone is a selective antagonist and serotonin reuptake inhibitor used in medicine to treat anxiety. Toxicological studies of trazodone succinate were carried out on the basis of the Department of Pharmacology of the Veterinary Faculty Stavropol State Agrarian University, Russia.
The results obtained in the study of acute toxicity of the drug Express Uspokoin® tablets allow us to identify the new drug as belonging to moderately dangerous substances for mammals.
When studying the subchronic toxicity of the drug in rats, it was found that its use for 90 days at doses 10...50 times higher than the therapeutic one does not cause changes in the clinical condition of experimental rats.
The totality of the experimental data obtained unambiguously confirms the good tolerability of the drug Express Uspokoin® tablets.
As a result of toxicological studies, it was found that the drug does not exhibit irritating and allergizing effects.
General principles of combating corruption in the countries of the Visegrad Four: the experience of the Czech Republic
Authors: Makarenko V. S. , Bakumov O. S. 
Published: March 2023

The article is devoted to the study of the general principles of combating corruption in the territory of the Czech Republic. The fight against corruption, according to the Ministry of Regional Development of the Czech Republic, is a long-term process that requires the cooperation of all elements of the public administration system and includes prevention activities, transparency of all processes and the imposition of sanctions for violations. The purpose of the article is to study the experience of implementing anti-corruption activities on the territory of one of the countries of the Visegrad Group, namely the Czech Republic, establishing the path taken by the Czech Republic in the field of prevention and countering corruption, building its anti-corruption bodies, forming a strategy and clarifying the possibility of taking into account certain aspects in the activities of state bodies authorities and local self-government of Ukraine.
As a result of the study, the place of the Czech Republic and Ukraine in the global rating of corruption perception in 2021 has been clarified. The definition of corruption in Ukraine and the Czech Republic has been given. The nature of the activity of the Visegrad Group as an institutional organization has been outlined. It has been determined that it is customary to distinguish three time periods of the Czech Republic's development on the way to overcoming corruption.
The priority areas of combating corruption, determined by the government of the Czech Republic and enshrined in the Anti-corruption agenda, have been considered, including: creation of an independent, efficient, professional, integrated and corruption-resistant state administration; transparency and efficiency of the decision-making process and the legislative process; regulation of the system of free access to information, etc. There are two groups of main state and non-state organizations in the Czech Republic whose activities are aimed at preventing and combating corruption: 1) those engaged in analytical and investigative activities; 2) those that carry out preventive, educational and coordination activities. The first group includes the Police of the Czech Republic, the General Inspectorate of Security Forces, the Prosecutor's Office of the Czech Republic, and the Financial and Analytical Unit of the Ministry of Finance. The second group includes the Anti-Corruption Commission of the Police of the Czech Republic, the Ombudsman of the Police of the Czech Republic and the Fire and Rescue Corps of the Czech Republic, the State Defender of Rights in the Czech Republic, the Institute of Public Administration in Prague, etc.
It has been concluded that it is necessary to promote the role of the public in the field of control over anti-corruption activities and the possibility to take as a basis the experience of the functioning of public initiatives of the Czech Republic.
Synthesis and Characterization of Biphasic Calcium Phosphate Substituted Cerium as a Potential Osteoporotic Bone Filler
Authors: Windarti Tri , Nulandaya Limpat , Widjijono Widjijono , Nuryono Nuryono 
Published: March 2023

Biphasic calcium phosphate substituted cerium (BCP/Ce) is a potential material for osteoporotic bone filler. Synthesis of BCP/Ce was conducted by the sol-gel method. This work aimed to study the influence of cerium as a precursor on the crystal structures, surface properties, and agglomeration of BCP/Ce. A series of samples were prepared by various Ce percentages (0.5–16%) and a constant molar ratio of (Ca + Ce)/P = 1.2. A structural study by Rietveld refinement calculation confirmed that synthesis without Ce produced BCP that contained hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) at a ratio of 93:7. The presence of Ce increased β-TCP content to 73% for the use of Ce 8%. None of Ca in the HA structure was replaced by Ce. Otherwise, Ce replaced Ca in β-TCP structure by isomorphic substitution at the Wyckoff site of 6a (0,0,-0.085) or Ca (4) position. As the maximum occupancy of Ca (4) = 43%, about 17% of that was substituted by Ce for the use of 14% Ce. Ce was found in two states as Ce3+ and Ce4+ ions with Ce3+/Ce4+ ratio > 1. The presence of Ce on the particle surface caused a change in the particle shape, from plate-like to spherical. The particle size decreased to <100 nm with the increase of Ce content. The rise of Ce content in BCP decreased the luminescent property due to the increase of oxygen vacancies. The negative value of Zeta potential confirms that BCP/Ce surface can accommodate bone cell proliferation.
Pressurized Liquid Extraction for the Recovery of Carotenoids and Functional Compounds from Green and Orange Dunaliella salina Biomasses
Authors: Yaiche Achour Hafsa , Blanco Llamero Cristina , Saadi Sid Ahmed , Bouras Noureddine , Zitouni Abdelghani , Señoráns Javier 
Published: March 2023

In recent years, intensive research has been conducted on natural carotenoids extraction using several processes. Conventional extraction methods require high amounts of solvents and a long extraction time. However, pressurized liquid extraction demonstrated to be an interesting method. The extraction efficiencies of pressurized liquid for the recovery of carotenoids, from the green and the orange biomasses of the microalga Dunaliella salina DunaDZ1, are described. Organic solvents were tested including ethanol, n-hexane, ethyl acetate and a mixture of n-hexane:ethanol (3:4). Moreover, three extraction temperatures were used (90, 120 and 150 °C) at constant pressure. Extraction efficiency and extracts characterization were conducted. Results have shown that temperature has a positive effect on extraction yield. HPLC characterization showed that β-carotene is the main carotenoid in the orange biomass, and lutein in the green biomass, with the presence of other minor carotenoids in both biomasses. The highest carotenoid amounts were found in the n-hexane orange biomass extract, with β-carotene isomers as the main carotenoid (138.54 and 357.10 mg/g of dry extract, for cis and trans isomers, respectively). Otherwise, extracts obtained at the lowest tested temperature provided the best carotenoid yields. The best results for the antioxidant activity were obtained at 120 °C for orange biomass ethyl acetate extract.
Effect of β-blockers on mortality in patients with sepsis: A propensity-score matched analysis
Authors: Ge Cheng-Long , Zhang Li-Na , Ai Yu-Hang , Chen Wei , Ye Zhi-Wen , Zou Yu , Peng Qian-Yi 
Published: March 2023

ObjectivesWe aimed to evaluate the association between β-blocker therapy and mortality in patients with sepsis.MethodsPatients with sepsis were selected from the Medical Information Mart for Intensive Care (MIMIC)-III. Propensity score matching (PSM) was used to balance the baseline differences. A multivariate Cox regression model was used to assess the relationship between β-blocker therapy and mortality. The primary outcome was the 28-day mortality.ResultsA total of 12,360 patients were included in the study, involving 3,895 who received β-blocker therapy and 8,465 who did not. After PSM, 3,891 pairs of patients were matched. The results showed that β-blockers were associated with improved 28- (hazards ratio (HR) 0.78) and 90-day (HR 0.84) mortality. Long-acting β-blockers were associated with improved 28-day survival (757/3627 [20.9%] vs. 583/3627 [16.1%], P &lt; 0.001, HR0.76) and 90-day survival (1065/3627 [29.4%] vs.921/3627 [25.4%], P &lt; 0.001, HR 0.77). Short-acting β-blocker treatment did not reduce the 28-day and 90-day mortality (61/264 [23.1%] vs. 63/264 [23.9%], P = 0.89 and 83/264 [31.4%] vs. 89/264 [31.7%], P = 0.8, respectively).Conclusionsβ-blockers were associated with improved 28- and 90-day mortality in patients with sepsis and septic shock. Long-acting β-blocker therapy may have a protective role in patients with sepsis, reducing the 28-day and 90-day mortality. However, short-acting β-blocker (esmolol) treatment did not reduce the mortality in sepsis.
Comprehensive analysis of atherosclerotic plaques reveals crucial genes and molecular mechanisms associated with plaque progression and rupture
Authors: Zhu Guoqi , Gao Yanhua , Qian Jun , Lai Yan , Lin Hao , Liu Chengxing , Chen Fei , Liu Xuebo 
Published: March 2023

BackgroundPlaque rupture and acute atherothrombosis, resulting from continued progression of atherosclerotic plaques (APs), are major contributors to acute clinical events such as stroke or myocardial infarction. This article aimed to explore the gene signatures and potential molecular mechanisms in the progression and instability of APs and to identify novel biomarkers and interventional targets for AP rupture.MethodsThe microarray data were downloaded from the Gene Expression Omnibus (GEO) database and grouped into discovery and validation cohorts. In the discovery cohort, Weighted Gene Co-Expression Network Analysis was performed for finding co-expression modules, and the Metascape database was used to perform functional enrichment analysis. Differential Expression Genes analysis subsequently was performed in the validation cohort for verification of the obtained results. Common genes were introduced into Metascape database for protein–protein interaction and functional enrichment analysis. We constructed the miRNAs–mRNAs network with the hub genes. Moreover, gene expression profiles of peripheral blood mononuclear cells (PBMCs) from peripheral blood of patients with plaque rupture were analyzed by high-throughput sequencing, and the diagnostic power of hub genes was verified by receiver operating characteristic (ROC) analysis.ResultsIn the discovery cohort, the brown module in GSE28829 and the turquoise module in GSE163154 were the most significant co-expression modules. Functional enrichment analysis of shared genes suggested that “Neutrophil degranulation” was the most significantly enriched pathway. These conclusions were also demonstrated by the validation cohort. A total of 16 hub genes were identified. The miRNA–mRNA network revealed that hsa-miR-665 and hsa-miR-512-3p might regulate the “Neutrophil degranulation” pathway through PLAU and SIRPA, which might play a significant role in AP progression and instability. Five hub genes, including PLAUR, FCER1G, PLAU, ITGB2, and SLC2A5, showed significantly increased expression in PBMCs from patients with plaque rupture compared with controls. ROC analysis finally identified three hub genes PLAUR, FCER1G, and PLAU that could effectively distinguish patients with APs rupture from controls.ConclusionsThe present study demonstrated that the “neutrophil degranulation” signaling pathways and identified novel mRNA and miRNA candidates are closely associated with plaque progression and instability. The hub genes FCER1G, PLAUR, and PLAU may serve as biomarkers for the prospective prediction of AP rupture.