bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive functional therapy and non-steroidal anti-inflammatory drugs in the treatment of low back pain
Authors: Zinovyeva O. E. , Golovacheva A. A. 
Published: January 2023

A multidisciplinary approach including drug and non-drug methods is recommended for the treatment of chronic low back pain (CLBP). Kinesiotherapy, psychological methods, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be highly effective for CLBP. All of the listed methods contribute to significant relief and relief of pain, increase the patient’s social and physical activity, and improve the emotional state. Psychological methods help patients cope with catastrophizing pain, increase daily activities, and reduce the likelihood of disease recurrence. Results from clinical studies and systematic reviews demonstrate the effectiveness of psychological techniques such as cognitive behavioral therapy (CBT) and mindfulness therapy (mindfulness) in the treatment of CLBP. Cognitive Functional Therapy (CFT) is a promising new psychological method that was created on the basis of CPT. Clinical studies have been conducted confirming the efficacy of CFT in CLBP. CFT is aimed at regular therapeutic exercises, normalization of motor activity with avoidance of excessive physical and static exertion, avoidance of sedentary lifestyle and normalization of sleep, which is often disturbed in chronic back pain. In practice, patients with CLBP often have low adherence to increased physical activity during the day, to therapeutic exercises. In most cases, this is due to the fact that in the first days of increased physical activity there is an increase in pain. Patients mistakenly fear further progression of pain and disease. Prescribing NSAIDs usually results in pain reduction as early as the first days of administration, so patients with chronic musculoskeletal pain have an increased desire to engage in physical activity and therapeutic exercises. The choice of a particular NSAID medication is made individually, taking into account the co-morbidities and the risk of possible side effects. We discuss the use of nimesulide in CLBP.
Optimizing the management of patients with persistent postural perceptual dizziness and migraine
Authors: Zastenskaya E. N. , Antonenko L. M. 
Published: January 2023

Introduction. Dizziness and headache are among the most frequent complaints in neurological practice, which significantly reduce the quality of life of patients, so the development of effective methods of managing patients with persistent postural perceptual vertigo (PPPD) and migraine is an urgent task.Objective. To study and optimize typical management practices of patients with PPPD and migraine.Materials and methods. Twenty-two patients aged 39.3 ± 10.2 years with PPPD and migraine according to the diagnostic criteria of the Classification of Vestibular Disorders of the Barany Society were examined. During the study we used Hospital Anxiety and Depression scale, Beck Depression Inventory, State-Trait Anxiety Inventory, clinical otoneurological examination, otoneurological questionnaire, Dizziness Handicap Inventory, videonystagmography. After the diagnosis was made, the patients were prescribed a complex treatment. To relieve an acute attack of vertigo, dimenhydrinate was prescribed, as well as the combined drug cinnarizine 20 mg + dimenhydrinate 40 mg Arlevert, which in a number of studies showed high efficacy and good tolerability. One month later, the patients were examined in the dynamics.Results. Patients with PPPD had migraine without aura (54%), migraine with aura (14%), and vestibular migraine (32%). The level of anxiety was significantly higher in the group of patients with PPPD and vestibular migraine. There was moderate severity of dizziness in all groups of patients, after one month against the background of ongoing therapy severity of dizziness significantly decreased in all groups. Diagnoses “PPPD” and “vestibular migraine” were not set beforehand in any of the examined patients.Conclusions. The study showed a low level of diagnosis of PPPD and vestibular migraine. Management of patients with PPPD and migraine requires a complex approach.
Determination of Clark unit hydrograph parameters for estimating probable maximum flood
Authors: Lee Jinwook , Yoo Chulsang 
Published: January 2023

Abstract
The probable maximum flood (PMF) is the flood caused by the probable maximum precipitation (PMP). A unit hydrograph (UH) is generally used to derive the PMF for the given PMP, but a method is needed to modify the UH parameters to reflect the PMP condition. This study presents a new method using the estimated channel velocity to modify the Clark UH parameters under the ordinary condition into those under the PMP condition. This study considers major dam basins in Korea and evaluates the application results in comparison to several previous studies. As application results of the proposed method, the Clark UH parameters under the PMP condition are found to be within the range 39–53% of those under the ordinary condition, with their mean of about 44%. The UH derived by applying this mean ratio shows that its peak time and the peak flow are just 44 and 227% of the UH under the ordinary condition, respectively. This change from the ordinary condition to the PMP condition is more extreme in Korea than that in Australia and the United Kingdom. This extreme change seems to be due to the climate in Korea, located in the Asian Monsoon region.
The Derivatives of Cromolyn Ameliorate the Abnormal Misfolding of
Amyloid Proteins and Neuroinflammation in the Neural Cells
Authors: Lee Joo-Hee , Lakshmana Perumal Nivethasri , Kwon Sehee , Kim Hee-Cheol , Ahn Na-Hyun , Choi Su-Bin , Hwang Eunjin , Song Hyoryeong , Elmaleh David R. , Kim Aryun , Yang Woong-Suk , Kim Cheorl-Ho , Jang Byeong-Churl , Choi Sungwoon , Yang Seung-Hoon 
Published: January 2023

Background:
The representative symptom of Alzheimer’s Disease (AD) has
mainly been mentioned to be misfolding of amyloid proteins, such as amyloid-beta (Aβ)
and tau protein. In addition, the neurological pathology related to neuroinflammatory signaling
has recently been raised as an important feature in AD. Currently, numerous drug
candidates continue to be investigated to reduce symptoms of AD, including amyloid proteins
misfolding and neuroinflammation.

Objective:
Our research aimed to identify the anti-AD effects of two chemical derivatives
modified from cromoglicic acid, CNU 010 and CNU 011.

Methods:
CNU 010 and CNU 011 derived from cromoglicic acid were synthesized. The
inhibitory effects of Aβ and tau were identified by thioflavin T assay. Moreover, western
blots were conducted with derivates CNU 010 and CNU 011 to confirm the effects on inflammation.

Results:
CNU 010 and CNU 011 significantly inhibited the aggregation of Aβ and tau
proteins. Moreover, they reduced the expression levels of mitogen-activated protein
(MAP) kinase and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-
κB) signaling proteins, which are representative early inflammatory signaling markers.
Also, the inhibitory effects on the lipopolysaccharide (LPS)-induced cyclooxygenase
(COX)-2 and inducible nitric oxide synthase (iNOS) expression referring to late inflammation
were confirmed.

Conclusion:
Our results showing multiple beneficial effects of cromolyn derivatives
against abnormal aggregation of amyloid proteins and neuroinflammatory signaling provide
evidence that CNU 010 and CNU 011 could be further developed as potential drug
candidates for AD treatment.
A Compound Essential Oil Alters Stratum Corneum Structure, Potentially
Promoting the Transdermal Permeation of Hydrophobic and Hydrophilic
Ingredients
Authors: Yang Na , Ai Xinyi , Cheng Kang , Wu Yihan , Lu Zhi , Liu Zhenda , Guo Teng , Feng Nianping 
Published: January 2023

Background:
The stratum corneum (SC) is the main barrier of the skin, and cosmeceuticals
are different from ordinary cosmetics in that they need to deliver active ingredients targeting specific
skin problems through the SC into the deeper layers of the skin. Thus, we designed a compound essential
oil (CEO) extracted from Salvia miltiorrhiza Bge and Cinnamomum cassia Presl, supplemented
with borneol to deliver active ingredients through the SC.

Methods:
The CEO was prepared by flash extraction combined with the microwave method. Moreover,
the main components of the CEO were determined using gas chromatography-mass spectrometry (GCMS).
Visualization techniques, such as scanning electron microscopy (SEM), haematoxylin-eosin (HE)
staining, and confocal laser scanning microscopy (CLSM), were used to study the permeationpromoting
mechanism of the CEO on the skin. Furthermore, the permeation-promoting effects of the
CEO on both hydrophobic and hydrophilic ingredients were tested via in vitro skin penetration experiments
and in vivo microdialysis experiments.

Results:
The results indicated the ability of the CEO to alter the structure of the SC, leading to enhanced
transdermal permeation of hydrophobic and hydrophilic ingredients. The 1.5% CEO group demonstrated
the best permeation-promoting effect compared to the other CEO groups and blank groups (P<0.05).
Furthermore, the CEO displayed an expedited permeability-promoting effect on hydrophobic ingredients
compared to hydrophilic ingredients.

Conclusion:
It is concluded that the prepared CEO can promote the transdermal permeation of hydrophobic
and hydrophilic ingredients. This study will provide a reference for the application of the prepared
CEO in the development of cosmeceuticals with natural efficacy.
Why Do Pregnant Mothers Prefer to Give Birth at Home After they
Attended Antenatal Care Visits in Southern Ethiopia? A Phenomenological
Study Design
Authors: Temesgen Tesfaye , Figa Zerihun 
Published: January 2023

Background:
Common causes of maternal deaths are direct obstetric complications that can
be managed by healthcare providers in health facilities. Women giving birth at home have a higher
contribution to maternal mortality and morbidity as well as a poor fetal outcome. Sub-Saharan Africa
accounts for an estimated 66% of all maternal deaths. This study aimed to explore why pregnant
mothers prefer to deliver at home after antenatal care follow-up in South Ethiopia.

Methods:
Phenomenological study design was used to explore the factors that push women to home
delivery despite antenatal care being provided. A purposive technique was used to recruit the twenty
pregnant mothers for the focused group discussion and ten healthcare providers for an in-depth interview.
The data saturation approach determined the sample size. A focused group discussion was
commenced with women who had ANC follow-ups during pregnancy gave birth at home and came for
immunization services in health facilities. The in-depth interview was done with physicians, midwives,
health officers, and traditional birth attendants. Data were translated into English by a bilingual
translator and analyzed thematically using Open Code software. The result was presented in a table
and text.

Results:
The study includes a total of 20 women for FGDs, seven health professionals, and three traditional
birth attendants from selected health facilities. The age of most FGD participants was 25-35
years. The ideas of the participants were grouped into five themes and subthemes. Fear of health professionals’
disrespect and abuse, a family decision on the place of delivery, lack of transport and money,
traditional birth attendants’ acceptability by the community, and sociocultural influences were
commonly raised as barriers to institutional delivery.

Conclusion:
Most of the barriers are related to behavioural issues, and effort should be made to
change the behaviour of the community in general. Improving the quality of the antenatal care service
and adequate counseling may be an appropriate intervention to increase health facilities' delivery.
Quantification of Celiac Disease Severity Using Video Capsule Endoscopy:
A Comparison of Human Experts and Machine Learning Algorithms
Authors: Chetcuti Zammit Stefania , McAlindon Mark E. , Greenblatt Elliot , Maker Michael , Siegelman Jenifer , Leffler Daniel A. , Yardibi Ozlem , Raunig David , Brown Terry , Sidhu Reena 
Published: January 2023

Background:
Video capsule endoscopy (VCE) is an attractive method for diagnosing and
objectively monitoring disease activity in celiac disease (CeD). Its use, facilitated by artificial intelligence-
based tools, may allow computer-assisted interpretation of VCE studies, transforming a subjective
test into a quantitative and reproducible measurement tool.

Objective:
To evaluate and compare objective CeD severity assessment as determined with VCE by
expert human readers and a machine learning algorithm (MLA).

Methods:
Patients ≥ 18 years with histologically proven CeD underwent VCE. Examination frames
were scored by three readers from one center and the MLA, using a 4-point ordinal scale for assessing
the severity of CeD enteropathy. After scoring, curves representing CeD severity across the entire
small intestine (SI) and individual tertiles (proximal, mid, and distal) were fitted for each reader and
the MLA. All comparisons used Krippendorff’s alpha; values > 0.8 represent excellent to ‘almost perfect’
inter-reader agreement.

Results:
VCEs from 63 patients were scored. Readers demonstrated strong inter-reader agreement on
celiac villous damage (alpha=0.924), and mean value reader curves showed similarly excellent agreement
with MLA curves (alpha=0.935). Average reader and MLA curves were comparable for mean
and maximum values for the first SI tertile (alphas=0.932 and 0.867, respectively) and the mean value
over the entire SI (alpha=0.945).

Conclusion:
A novel MLA demonstrated excellent agreement on whole SI imaging with three expert
gastroenterologists. An ordinal scale permitted high inter-reader agreement, accurately and reliably
replicated by the MLA. Interpreting VCEs using MLAs may allow automated diagnosis and disease
burden assessment in CeD.
Green Synthetic Approach: A Well-organized Eco-friendly Tool for
Synthesis of Bio-active Fused Heterocyclic Compounds
Authors: Karmakar Rajiv , Mukhopadhyay Chhanda 
Published: January 2023

Background:
Heterocyclic chemistry is a highly significant and exciting segment of organic
chemistry because of its high biological and pharmacological activities. An environmentally benign and
synthetically proficient way of synthesis of fused heterocycles is the major goal of modern organic synthesis
by developing greener synthetic strategies. Green synthetic approaches address our future
challenges for the development of a bioactive heterocycle framework with maximum productivity and
minimum side products. A few decades ago, novel tools for manufacturing fused heterocycles had a huge
impact on organic chemistry. Subsequently, the preparation of fused heterocycles through a synthetically
efficient and environmentally benign route is the important purpose of modern synthetic chemistry.

Methods:
This review consists of green synthetic strategies for the synthesis of N/O-containing various
bio-active fused heterocyclic compounds using modern organic transformations including:
cyclocondensation, cycloaddition, one-pot, multi-components, and other modular reactions. Some greener
unconventional techniques such as ultrasound and microwave-assisted method, green solvent and solventfree
reaction medium are important modes adopted towards sustainability.

Objective:
This review aims to reflect the sustainability scope in green approaches to the synthesis of
N/O-containing bio-active fused heterocyclic compounds so that economically and environmentally
viable synthetic methodologies may be selectively identified and applied in academia and industries.

Conclusion:
In this review, we have discussed the recent advancements in green and eco-friendly tools
for the synthesis of N/O-based bio-active fused heterocyclic compounds that will lead to further research
in this field.
Quality by Design-based RP-HPLC Method for Estimation of Curcumin in
Rat Plasma and Fecal Microbiota Extract-based Solid Self-nano Emulsifying
Drug Delivery System
Authors: Corrie Leander , Gulati Monica , Kaur Jaskiran , Awasthi Ankit , Vishwas Sukriti , Ramanunny Arya Kadukkattil , Khursheed Rubiya , Dua Kamal , Chellappan Dinesh Kumar , Singh Sachin Kumar 
Published: January 2023

Background:
Curcumin (CRM) is known to possess various therapeutic properties,
such as anti-inflammatory and antidiabetic properties, and is, therefore, considered to be an effective
therapeutic.

Objective:
A sensitive method for the estimation of CRM in plasma, as well as fecal matter-based
solid self-nano emulsifying drug delivery system (S-SNEDDS), has been reported for the first
time.

Methods:
A bioanalytical method was optimized using Box-Behnken Design having 13 runs and 3
responses. The optimized method was developed using methanol and water (70:30 v/v) with a flow
rate of 1 mL/min. Quercetin was used as an internal standard. A specificity test was also performed
for the developed CRM solid self-nano emulsifying drug delivery system.

Results:
The retention time of CRM was found to be 14.18 minutes. The developed method was
validated and found to be linear in the range of 50-250 ng/mL with an R2 of 0.999. Accuracy studies
indicated that CRM had a percentage recovery of less than 105% and more than 95%, respectively.
Precision studies were carried out for inter, intraday, and inter-analyst precision, and the
%RSD was found to be less than 2%. The limit of detection (LOD) and limit of quantification
(LOQ) were found to be 3.37 ng/mL and 10.23 ng/mL, respectively. Stability studies for shortterm,
long term and freeze-thaw cycles showed a %RSD of less than 2%, indicating the stability of
CRM in the plasma matrix. Moreover, the blank fecal microbiota extract slurry did not show any
peak at the retention time of CRM in a CRM-loaded solid nanoemulsifying drug delivery system
containing fecal microbiota extract indicating its specificity.

Conclusion:
Hence, the developed method can have clinical implications as it helps estimate CRM
in blood samples and also provides a simple and sensitive method for the estimation of plant-based
flavonoids along with fecal microbiota extract formulations.
Novel Approaches of Self Emulsifying Drug Delivery Systems and Recent
Patents: A Comprehensive Review
Authors: Nandal Rimmy , Tahlan Sumit , Deep Aakash 
Published: January 2023

Abstract:
The main aim of the current work is to set up a revolutionary Self Nano-emulsifying
drug delivery system to improve the necessary bio-availability and to boost clinical efficacy when
administered orally. This study's main target is to develop a novel self-nano emulsifying drug delivery
system (SNEDDS) for orally administered, poorly water-soluble medicines. SNEDDS is designed
to intensify weakly water dissolvable or lipophilic drugs. SNEDDS is designed to intensify
weakly water dissolvable or lipophilic drugs. It contains a micro- or nano-emulsion of oil carrying
medicament that spontaneously agitates an aqueous medium. For enhancing the solubility of lipophilic
medicines, SNEDDS is the most significantly used in biopharmaceutics classification system
[BCS class] II and IV pharmaceuticals. The improved rate of dissolution and prevention of interfacial
tension are clearly demonstrated by SNEDDS. In aqueous mediums, such as gastrointestinal
fluid, SNEDDS produces a stable emulsion after dilution.
Novel Information Regarding the Treatment of Helicobacter pylori Infection:
A Systematic Review and Meta-analysis of Randomized Clinical Trials
Authors: Kiani Faezeh , Khademolhosseini Sara , Mohammadi Jasem , Tavasol Arian , Hajibeygi Ramtin , Fathi Mobina , Dousti Majid 
Published: January 2023

Objective:
Helicobacter pylori infects at least 50% of the world’s human population. The
current study aimed to assess and compare the efficacy of triple versus quadruple therapy.

Methods:
Randomized clinical trials (RCTs) consisting of triple and quadruple therapy were identified
through electronic and manual searches in the national and international online databases (IsI, Magiran,
Embase, PubMed, and Scopus). The random-effects model was applied to pool analysis. Funnel
plots and the Egger test were used to examine publication bias.

Results:
After a detailed review of the selected articles, 80 RCTs were included in the meta-analysis;
it was based on using triple and quadruple therapy as the first and second-line treatment. The results
showed that quadruple therapy in the first-line treatment had a higher eradication rate than triple therapy.
Overall, the eradication rate with triple therapy was 74% (95% CI, 71%-77%) for intention-totreat
(ITT) analysis and 80% (95% CI, 77%-82%) for per-protocol (PP) analysis. Generally, the eradication
rate with quadruple therapy was 82% (95% CI, 78.0%-86.0%) for ITT analysis and 85% (95%
CI, 82.0%-89.0%) for PP analysis. The analysis also revealed that quadruple therapy was more effective
for 7 or 10 days.

Conclusion:
The current study results demonstrated that quadruple therapy has better effectiveness
than triple therapy as the first-line treatment; however, in the second-line treatment, the effectiveness
of quadruple and triple regimens is almost similar. The effectiveness of quadruple therapy in the Asian
population was found to be slightly higher than that of triple therapy, while this difference was considerably
higher in the European population.
A Decentralized Marketplace for Patient-Generated Health Data: Design Science Approach
Authors: Subramanian Hemang 
Published: January 2023

Background
Wearable devices have limited ability to store and process such data. Currently, individual users or data aggregators are unable to monetize or contribute such data to wider analytics use cases. When combined with clinical health data, such data can improve the predictive power of data-driven analytics and can proffer many benefits to improve the quality of care. We propose and provide a marketplace mechanism to make these data available while benefiting data providers.

Objective
We aimed to propose the concept of a decentralized marketplace for patient-generated health data that can improve provenance, data accuracy, security, and privacy. Using a proof-of-concept prototype with an interplanetary file system (IPFS) and Ethereum smart contracts, we aimed to demonstrate decentralized marketplace functionality with the blockchain. We also aimed to illustrate and demonstrate the benefits of such a marketplace.

Methods
We used a design science research methodology to define and prototype our decentralized marketplace and used the Ethereum blockchain, solidity smart-contract programming language, the web3.js library, and node.js with the MetaMask application to prototype our system.

Results
We designed and implemented a prototype of a decentralized health care marketplace catering to health data. We used an IPFS to store data, provide an encryption scheme for the data, and provide smart contracts to communicate with users on the Ethereum blockchain. We met the design goals we set out to accomplish in this study.

Conclusions
A decentralized marketplace for trading patient-generated health data can be created using smart-contract technology and IPFS-based data storage. Such a marketplace can improve quality, availability, and provenance and satisfy data privacy, access, auditability, and security needs for such data when compared with centralized systems.