bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative research and development activities on high energy and high current isochronous proton accelerator
Authors: Zhang Tianjue , Fu Wei , Wang Chuan , Pei Shilun , Yin Zhiguo , Zhou Hongji , Yin Ziye , Zhang Suping , Liu Jingyuan , Zhu Xiaofeng , Wang Fei , Wang Yang , Cai Hongru , Pan Gaofeng , Mu Xueer , Lin Jun , Zhao Bohan , He Aolai , Chu Zhichao , Hu Mingzhi , Song Qiqi 
Published: March 2023

Abstract
The MW class proton accelerators are expected to play
important roles in many fields, attracting institutions to continue
researching and tackling key problems. The continuous wave (CW)
isochronous accelerator obtains a high-power beam with higher energy
efficiency, which is very attractive to many applications. Scholars
generally believe that the energy limitation of the isochronous
cyclotron is ∼1 GeV. To get higher beam power by the
isochronous machine, enhancing the beam focusing become the most
important issue.
Adjusting the radial gradient of the average magnetic field makes
the field distribution match the isochronism. When we adjust the
radial gradient of the peak field, the first-order gradient is
equivalent to the quadrupole field, the second-order, the hexapole
field, and so on. Just like the synchrotron, there are quadrupoles,
hexapole magnets, and so on, along the orbits to get higher energy,
as all we know.
If we adjust the radial gradient for the peak field of an FFA's FDF
lattice and cooperate with the angular width (azimuth flutter) and
spiral angle (edge focusing) of the traditional cyclotron pole, we
can manipulate the working path in the tune diagram very
flexibly. During enhancing the axial focusing, both the beam
intensity and the energy of the isochronous accelerator are
significantly increased. Here a 2 GeV CW FFA with 3 mA of average
beam intensity design is presented. It is essentially an isochronous
cyclotron although we use 10 FDF lattices. The key difficulty is
that the magnetic field and each order of gradient should be
accurately adjusted in a large radius range.
As a high-power proton accelerator with high energy efficiency, we
adopt high-temperature superconducting (HTS) technology for the
magnets. 15 RF cavities with a Q value of 90000 provide energy gain
per turn of ∼15 MeV to ensure the CW beam intensity reaches 3
mA. A 1:4 scale, 15-ton HTS magnet, and a 1:4 scale, 177 MHz cavity
have been completed. The results of such R&D will also be presented
in this paper.
Status update of the Charge Stripper Rings project
Authors: Imao H. 
Published: March 2023

Abstract
The RIKEN RI (radioactive isotope) Beam Factory (RIBF)
provides the world's most intense heavy ion beams exceeding
345 MeV/u and is the primary facility for in-flight RI beam
generation. The RIBF has steadily improved its performance. In
particular, the intensity of the uranium beam, which is critical for
producing in-flight fission RI beams, has been dramatically
increased by a factor of 240 compared to 2008. To further increase
the intensity of the uranium beam, a new acceleration scheme using
charge stripper rings (CSRs) has been proposed as a cost-effective
way to increase charge stripping efficiency. In this paper, we
discuss the key design issues of CSR and required upgrades of
existing ring cyclotrons with the introduction of CSR and
space-charge effects.
Examining the spatially varying and interactive effects of green and blue space on health outcomes in Northern Ireland using multiscale geographically weighted regression modeling
Authors: Wang Ruoyu , Grekousis George , Maguire Aideen , McKinley Jennifer M , Garcia Leandro , Rodgers Sarah E , Hunter Ruth F 
Published: March 2023

Abstract
Previous studies have mainly examined the independent effects of green or blue space on health from a perspective of spatial homogeneity, which neglects their interactive or spatially varying effects. Here, we examined the spatially varying and interactive effects of green and blue space on health using open access data in Northern Ireland (NI). Aggregate health data was collected from 2017 Northern Ireland Multiple Deprivation Measure at the Super Output Area (SOA) level. Green and blue spaces were extracted from Land Cover Map data. The proportion of grassland and the proportion of woodland for each SOA were calculated as proxies for green space, while the proportion of water bodies was calculated for measuring blue space. Spatially varying effects of green and blue space were modelled using multiscale Geographic Weighted Regression (MGWR). Interaction terms between green and blue spaces were added into the MGWR models to test the interactive association of green and blue space on different health outcomes (e.g., preventable death ratio and cancer registrations). Results indicate that associations were distributed zonally, with green and blue spaces in eastern areas of NI more strongly associated with health outcomes than in western areas. Within these large regional zones, further spatially varying effects of different green and blue spaces were observed. Grassland was generally positively associated with some health outcomes (e.g., less preventable death ratio, cancer registrations ratio, multiple prescriptions ratio, and long-term health problem or disability ratio), while the results of woodland and water body were mixed. Water bodies were found to strengthen the effect of woodland and grassland. The above results indicate that green and blue space have independently and interactive spatially varying associations with different health outcomes in NI. It is also important to combine both green and blue space elements to enhance health impacts in future interventions.
Breast Explantation With Simultaneous Mastopexy and Volume Restoration: An Analysis of Clinical Outcomes and Prospective Quality of Life
Authors: Messa Charles A , Messa Charles A 
Published: March 2023

Abstract

Background
An increasing number of patients are undergoing explantation to alleviate symptoms attributed to the presence of a prothesis or dissatisfaction with the appearance of their breasts.

Objectives
The authors aim to evaluate the clinical effectiveness and quality of life (QoL) of simultaneous explantation, capsulectomy, and mastopexy for patients requesting implant removal.

Methods
Two hundred sixty-two simultaneous explantation, capsulectomy, and mastopexy (ECM) procedures were performed in 131 patients from 2009 to 2019. Prospective QoL assessment was administered for all patients. Inclusion criteria included a minimum postoperative follow-up of 6 months and completion of a practice-generated patient reported outcomes (PRO) questionnaire. Wilcoxon signed-rank test was performed to compare changes in QoL scores.

Results
Mean follow-up and BMI were 23 months (6 months to 8 years) and 24.8 kg/m2 (18–34 kg/m2), respectively. Mean age was 48.3 years (26–75 years). Autologous fat grafting was performed simultaneously in patients 47.3% (n = 62). The complication rate was 3.8% (n = 10 breasts) in 9 patients (6.9%). The overall reoperation rate was 7.3% of procedures (n = 19 breasts) and 9.2% of patients (n = 12), including secondary autologous fat grafting (11.3%, n = 7). PRO results demonstrated a significant improvement in all QoL domains, including physical well-being (P &lt; .005), psychological well-being (P &lt; .005), sexual well-being (P &lt; .005), breast shape (P &lt; .005), and breast appearance (P &lt; .005). With respect to breast implant illness symptoms, 59 patients (88.1%) noted reduced pain, myalgias/arthralgias, and fatigue after ECM.

Conclusions
This study presents an effective paradigm to manage implant removal through simultaneous explantation, capsulectomy, and mastopexy with acceptable clinical outcomes and a significant improvement in QoL and breast aesthetics.

Level of Evidence: 4
miWords: transformer-based composite deep learning for highly accurate discovery of pre-miRNA regions across plant genomes
Authors: Gupta Sagar , Shankar Ravi 
Published: March 2023

AbstractDiscovering pre-microRNAs (miRNAs) is the core of miRNA discovery. Using traditional sequence/structural features, many tools have been published to discover miRNAs. However, in practical applications like genomic annotations, their actual performance has been very low. This becomes more grave in plants where unlike animals pre-miRNAs are much more complex and difficult to identify. A huge gap exists between animals and plants for the available software for miRNA discovery and species-specific miRNA information. Here, we present miWords, a composite deep learning system of transformers and convolutional neural networks which sees genome as a pool of sentences made of words with specific occurrence preferences and contexts, to accurately identify pre-miRNA regions across plant genomes. A comprehensive benchmarking was done involving &gt;10 software representing different genre and many experimentally validated datasets. miWords emerged as the best one while breaching accuracy of 98% and performance lead of ~10%. miWords was also evaluated across Arabidopsis genome where also it outperformed the compared tools. As a demonstration, miWords was run across the tea genome, reporting 803 pre-miRNA regions, all validated by small RNA-seq reads from multiple samples, and most of them were functionally supported by the degradome sequencing data. miWords is freely available as stand-alone source codes at https://scbb.ihbt.res.in/miWords/index.php.
Timing of symptomatic venous thromboembolism after surgery: meta-analysis
Authors: Singh Tino , Lavikainen Lauri I , Halme Alex L E , Aaltonen Riikka , Agarwal Arnav , Blanker Marco H , Bolsunovskyi Kostiantyn , Cartwright Rufus , García-Perdomo Herney , Gutschon Rachel , Lee Yung , Pourjamal Negar , Vernooij Robin W M , Violette Philippe D , Haukka Jari , Guyatt Gordon H , Tikkinen Kari A O 
Published: March 2023

Abstract

Background
The timing at which venous thromboembolism (VTE) occurs after major surgery has major implications for the optimal duration of thromboprophylaxis. The aim of this study was to perform a systematic review and meta-analysis of the timing of postoperative VTE up to 4 weeks after surgery.

Methods
A systematic search of MEDLINE, Scopus, and CINAHL databases was performed between 1 January 2009 and 1 April 2022. Prospective studies that recruited patients who underwent a surgical procedure and reported at least 20 symptomatic, postoperative VTE events by time were included. Two reviewers independently selected studies according to the eligibility criteria, extracted data, and evaluated risk of bias. Data were analysed with a Poisson regression model, and the GRADE approach was used to rate the certainty of evidence.

Results
Some 6258 studies were evaluated, of which 22 (11 general, 5 urological, 4 mixed, and 2 orthopaedic postoperative surgical populations; total 1 864 875 patients and 24 927 VTE events) were eligible. Pooled evidence of moderate certainty showed that 47.1 per cent of the VTE events occurred during the first, 26.9 per cent during the second, 15.8 per cent during the third, and 10.1 per cent during the fourth week after surgery. The timing of VTE was consistent between individual studies.

Conclusion
Although nearly half of symptomatic VTE events in first 4 weeks occur during the first postoperative week, a substantial number of events occur several weeks after surgery. These data will inform clinicians and guideline developers about the duration of postoperative thromboprophylaxis.
Biomechanical induction of mild brain trauma in larval zebrafish: effects on visual startle reflex habituation
Authors: Beppi Carolina , Penner Marco , Straumann Dominik , Bögli Stefan Yu 
Published: March 2023

AbstractA mild traumatic brain injury is a neurological disturbance of transient or/and chronic nature after a direct blow of the head/neck or exposure of the body to impulsive biomechanical forces, indirectly affecting the brain. The neuropathological events leading to the clinical signs, symptoms and functional disturbances are still elusive due to a lack of sensitive brain-screening tools. Animal models offer the potential to study neural pathomechanisms in close detail. We recently proposed a non-invasive protocol for inducing concussion-like symptoms in larval zebrafish via exposure to rapid linearly accelerating–decelerating body motion. By mean of auditory ‘startle reflex habituation’ assessments—an established neurophysiological health index—we probed acute and chronic effects that mirror human concussion patterns. This study aimed at expanding our previous work by assessing the ensuing effects with visual—as opposed to auditory—‘startle reflex habituation’ quantifications, by using the same methodology. We observed that immediately after impact exposure, the fish showed impaired sensory reactivity and smaller decay constant, possibly mirroring acute signs of confusion or loss of consciousness in humans. By 30-min post-injury, the fish display temporary signs of visual hypersensitivity, manifested as increased visuomotor reactivity and a relatively enlarged decay constant, putatively reflecting human post-concussive sign of visual hypersensitivity. In the following 5–24 h, the exposed fish progressively develop chronic signs of CNS dysfunction, in the form of low startle responsivity. However, the preserved decay constant suggests that neuroplastic changes may occur to restore CNS functioning after undergoing the ‘concussive procedure’. The observed findings expand our previous work providing further behavioural evidence for the model. Limitations that still require addressment are discussed, advancing further behavioural and microscopic analyses that would be necessary for the validation of the model in its putative relatability with human concussion.
RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability
Authors: Jin Yu , Zhao Lei , Wang Shuhao , Zhang Xianglan , Quan Jishu , Lin Zhenhua , Piao Junjie 
Published: March 2023

Abstract
Iron metabolism plays an important role in maintaining cellular multiple biological functions. Dysfunction of iron homeostasis-maintaining systems was observed in many diseases, including cancer. Ribosomal L1 domain-containing 1 (RSL1D1) is an RNA-binding protein involved in multiple cellular processes, including cellular senescence, proliferation and apoptosis. However, the regulatory mechanism of RSL1D1 underlying cellular senescence and its biological process in colorectal cancer (CRC) is not clearly understood. Here, we report that RSL1D1 expression is downregulated by ubiquitin-mediated proteolysis in senescence-like CRC cells. RSL1D1, as an anti-senescence factor, is frequently upregulated in CRC, and elevated RSL1D1 prevents CRC cells from senescence-like phenotype, and correlated with poor prognosis of CRC patients. Knockdown of RSL1D1 inhibited cell proliferation, and induced cell cycle arrest and apoptosis. Notably, RSL1D1 plays important roles in regulating iron metabolism of cancer cells. In RSL1D1-knockdown cells, FTH1 expression was significantly decreased, while transferrin receptor 1 expression was increased, leading to intracellular ferrous iron accumulation, which subsequently promoted ferroptosis, indicated by the increased malondialdehyde and decreased GPX4 levels. Mechanically, RSL1D1 directly bounds with 3ʹ untranslated region of FTH1 and subsequently promoted the mRNA stability. Moreover, RSL1D1-mediated downregulation of FTH1 was also observed in H2O2-induced senescence-like cancer cells. Taken together, these findings support RSL1D1 plays an important role in regulating intracellular iron homeostasis in CRC, and suggest that RSL1D1 could be a potential therapeutic target for cancer treatment.
Concurrent Determination of Pridinol, Diclofenac and Impurity A by HPLC-UV
Authors: Rodríguez-Basso Ángeles Gloria , Bonafede Silvina Laura , Prado Héctor Juan 
Published: March 2023

Abstract
A reversed-phase high-performance liquid chromatography method was developed and validated for the simultaneous determination of pridinol, diclofenac and diclofenac-related compounds in tablet formulations. The proposed method is also suitable for content uniformity determination, for dissolution test and for stability studies. Separation was achieved on a base-deactivated silica C8 column, using 50 mM phosphate buffer (pH 2.5) and methanol (40:60 v/v) as mobile phase, at a flow rate of 1.0 mL/min and column temperature of 40°C. Ultraviolet detection was made at 225 nm. The method was validated for specificity, accuracy, precision (intraday and interday levels) and linearity for each analyte. For diclofenac impurity A, sensitivity was also studied. The method showed specificity and linearity (R2: 0.999 for the three analytes) over the assessed concentration range (diclofenac: 2.5–75.0 μg/mL, pridinol: 2.0–60.0 μg/mL and impurity A: 1.25–5.0 μg/mL) and demonstrated good precision as reflected by the low coefficient of variation in all cases. Recovery rates obtained were 99.81, 100.58 and 100.96% for diclofenac, pridinol and impurity A respectively, and for all three analytes, the variances of the concentrations tested were equivalent. The detection and quantitation limits for impurity A were 0.078 and 0.261 μg/mL, respectively.
Para-conduit diaphragmatic hernia following esophagectomy—the new price of minimally invasive surgery?
Authors: De Silva Inoka , Wee Melissa , Cabalag Carlos S , Fong Rebecca , Tran Kevin , Wu Michael , Schloithe Ann , Bright Tim , Duong Cuong Phu , Watson David I 
Published: March 2023

Summary
Esophageal Cancer is the seventh commonest cancer worldwide with poor overall survival. Significant morbidity related to open esophagectomy has driven practice toward hybrid, totally minimally invasive and robotic procedures. With the increase in minimally invasive approaches, it has been suggested that there might be an increased incidence of subsequent para-conduit diaphragmatic hernia. To assess the incidence, modifiable risk factors and association with operative approach of this emerging complication, we evaluated outcomes following esophagectomy from two Australian Centers. Prospectively collected databases were examined to identify patients who developed versus did not develop a para-conduit hernia. Patient characteristics, disease factors, treatment factors, operative and post-operative factors were compared for these two groups. A total of 24 of 297 patients who underwent esophagectomy were diagnosed with a symptomatic para-conduit diaphragmatic hernia (8.1%). The significant risk factor for hernia was a minimally invasive abdominal approach (70.8% vs. 35.5%; P = 0.004, odds ratio = 12.876, 95% CI 2.214–74.89). Minimally invasive thoracic approaches were not associated with increased risk. Minimally invasive abdominal approaches to esophagectomy doubled the risk of developing a para-conduit diaphragmatic hernia. Effective operative solutions to address this complication are required.
A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori
Authors: Xiang Youbin , Tsuchiya Dai , Guo Fengli , Gardner Jennifer , McCroskey Scott , Price Andrew , Tromer Eelco C , Walters James R , Lake Cathleen M , Hawley R Scott 
Published: March 2023

Abstract
Meiosis is usually described as 4 essential and sequential processes: (1) homolog pairing; (2) synapsis, mediated by the synaptonemal complex; (3) crossing over; and (4) segregation. In this canonical model, the maturation of crossovers into chiasmata plays a vital role in holding homologs together and ensuring their segregation at the first meiotic division. However, Lepidoptera (moths and butterflies) undergo 3 distinct meiotic processes, only one of which is canonical. Lepidoptera males utilize 2 meiotic processes: canonical meiosis that produces nucleated fertile sperm, and a noncanonical meiosis that produces anucleated nonfertile sperm which are nonetheless essential for reproduction. Lepidoptera females, which carry heteromorphic sex chromosomes, undergo a completely achiasmate (lacking crossovers) meiosis, thereby requiring an alternative mechanism to ensure proper homolog segregation. Here, we report that the development of a molecular cell biology toolkit designed to properly analyze features of meiosis, including the synaptonemal complex structure and function, in the silkworm Bombyx mori. In addition to standard homology searches to identify Bombyx orthologs of known synaptonemal complex encoding genes, we developed an ortholog discovery app (Shinyapp) to identify Bombyx orthologs of proteins involved in several meiotic processes. We used this information to clone genes expressed in the testes and then created antibodies against their protein products. We used the antibodies to confirm the localization of these proteins in normal male spermatocytes, as well as using in vitro assays to confirm orthologous interactions. The development of this toolkit will facilitate further study of the unique meiotic processes that characterize meiosis in Lepidoptera.
PsRGL1 negatively regulates chilling- and gibberellin-induced dormancy release by PsF-box1-mediated targeting for proteolytic degradation in tree peony
Authors: Gao Linqiang , Niu Demei , Chi Tianyu , Yuan Yanchao , Liu Chunying , Gai Shupeng , Zhang Yuxi 
Published: March 2023

Abstract
Tree peony bud endodormancy is a common survival strategy similar to many perennial woody plants in winter, and the activation of the GA signaling pathway is the key to breaking endodormancy. GA signal transduction is involved in many physiological processes. Although the GA-GID1-DELLA regulatory module is conserved in many plants, it has a set of specific components that add complexity to the GA response mechanism. DELLA proteins are key switches in GA signaling. Therefore, there is an urgent need to identify the key DELLA proteins involved in tree peony bud dormancy release. In this study, the prolonged chilling increased the content of endogenously active gibberellins. PsRGL1 among three DELLA proteins was significantly downregulated during chilling- and exogenous GA3-induced bud dormancy release by cell-free degradation assay, and a high level of polyubiquitination was detected. Silencing PsRGL1 accelerated bud dormancy release by increasing the expression of the genes associated with dormancy release, including PsCYCD, PsEBB1, PsEBB3, PsBG6, and PsBG9. Three F-box protein family members responded to chilling and GA3 treatments, resulting in PsF-box1 induction. Yeast two-hybrid and BiFC assays indicated that only PsF-box1 could bind to PsRGL1, and the binding site was in the C-terminal domain. PsF-box1 overexpression promoted dormancy release and upregulated the expression of the dormancy-related genes. In addition, yeast two-hybrid and pull-down assays showed that PsF-box1 also interacted with PsSKP1 to form an E3 ubiquitin ligase. These findings enriched the molecular mechanism of the GA signaling pathway during dormancy release, and enhanced the understanding of tree peony bud endodormancy.
A novel edge-marking method in pleural covering with video-assisted thoracic surgery
Authors: Fujiwara-Kuroda Aki , Hida Yasuhiro , Ujiie Hideki , Kaga Kichizo , Kato Tatsuya 
Published: March 2023

AbstractTotal pleural covering is implemented to reinforce the visceral pleura with surgical sheets. It has been adopted for diffuse cystic lung diseases such as lymphangioleiomyomatosis to prevent pneumothorax and has achieved good results. The procedure is technically demanding, because it is difficult to cover the entire visceral pleura without disarrangement and jamming of surgical sheets, especially during thoracoscopic surgery, where grasping of a wrong site might happen when unfolding the sheets. Herein, we report a technique to cover the entire pleura with dotted line folded sheets to ease the thoracoscopic procedure. We found that the use of this marking method made the procedure easier, with just a little ingenuity, because marking the edges of sheets with dashed lines clarifies the site that should be grasped, thus preventing the incidence of grasping the wrong part of the sheet. Pleural covering with dotted line folded surgical sheets is a useful method for reduced port thoracoscopic surgery.