bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional Integration of Meiotic Prophase I Progression and Early Oocyte Differentiation
Authors: Abt Kimberly M. , Bartholomew Myles A. , Nixon Anna , Richman Hanna E. , Gura Megan A. , Seymour Kimberly A. , Freiman Richard N. 
Published: January 2025

AbstractFemale reproductive senescence results from the regulated depletion of a finite pool of oocytes called the ovarian reserve. This pool of oocytes is initially established during fetal development, but the oocytes that comprise it must remain quiescent for decades until they are activated during maturation in adulthood. In order for developmentally competent oocytes to populate the ovarian reserve they must successfully initiate both meiosis and oogenesis. As the factors that regulate the timing and fidelity of these early events remain elusive, we assessed the precise function and timing of the transcriptional regulator TAF4b during meiotic prophase I progression in mouse fetal oocytes. Compared to matched controls, E14.5Taf4b-deficient oocytes enter meiosis I in a timely manner however, their subsequent progression through the pachytene-to-diplotene transition of meiotic prophase I is compromised. Moreover, this disruption of meiotic progression is associated with the reduced ability ofTaf4b-deficient oocytes to repair double-strand DNA breaks. Transcriptional profiling ofTaf4b-deficient oocytes reveals that between E16.5 and E18.5 these oocytes fail to coordinate the reduction of meiotic gene expression and the induction of oocyte differentiation genes. These studies reveal that TAF4b promotes the formation of the ovarian reserve in part by orchestrating the timely transition to meiosis I arrest and oocyte differentiation, which are often perceived as separate events.
The promoter ofZymomonas mobilisrespiratory NADH dehydrogenase (ndh) is induced by oxygen
Authors: Rubina Marta , Strazdina Inese , Rutkis Reinis , Kalnenieks Uldis 
Published: January 2025

AbstractExpression of the genes of engineered green fluorescent protein and theZymomonas mobilisnative malic enzyme from plasmid vectors under theZ. mobilisrespiratory NADH dehydrogenase promoter (Pndh) was strongly enhanced by aeration, both in the wild type Zm6 and its respiratory-deficient mutant derivative Zm6-ndhbackgrounds. Pndh in aerobically growing cultures was activated by about an order of magnitude relative to non-aerated control. Its induction approached the maximum level already at moderate aeration (1-5% oxygen saturation in the medium). The strength of Pndh under aerobic conditions was comparable to, or even surpassed that of the strongZ. mobilisnative promoter of glyceraldehyde-3-phosphate dehydrogenase. Although the mechanism of its oxygen-dependent induction is not known, Pndh might serve as a versatile inducible promoter forZ. mobilismetabolic engineering.HighlightsAeration activates theZ. mobilis ndhpromoter Pndh by about an order of magnitudeUnder aerobic conditions Pndh ranks among the strongest nativeZ. mobilispromotersPndh is induced already at low oxygen saturation range (1-5%)
Intuitive sensorimotor decisions under risk take Newtonian physics into account
Authors: Tatai Fabian , Straub Dominik , Rothkopf Constantin A. 
Published: January 2025

The success of our interactions with objects in natural tasks depends on generating motor actions, which are subject to sensorimotor variability, the objects’ physical properties, which are governed by the laws of kinematics, and the costs and benefits associated with the actions’ outcomes. Therefore, such interactions jointly involve sensorimotor control, intuitive physics, and decision-making under risk. Here, we devised a mixed reality experiment, which allows investigating human behavior involving the interaction of all three of these cognitive faculties. Participants slid pucks to target areas associated with monetary rewards and losses within an immersive, naturalistic virtual environment. In this task, signal-dependent variability inherent in motor control interacts non-linearly with the physical relationships governing objects’ motion under friction. By systematically testing generative models of behavior incorporating different assumptions about how participants may generate the slides, we find decisive evidence that participants’ decision under risk readily took their individual motor variability and Newtonian physics into account to gain monetary rewards without relying on trial by trial learning.Author summaryHumans are exceptionally proficient at manipulating objects in natural tasks. This skill requires integrating three cognitive faculties: 1. Sensorimotor-control, subject to inherent uncertainty and variability; 2. Intuitive physical reasoning as object manipulations are subject to physical dynamics; 3. Economic decision-making when actions have outcomes with monetary consequences. Here, we show that in a naturalistic, immersive object manipulation task, human participants plan their movements by taking into account how their sensorimotor variability interacts with the physical dynamics of object manipulation to optimize economic outcomes. Therefore, our findings suggest that in everyday naturalistic interactions with the world, humans can integrate these three cognitive faculties.
One-loop electron self-energy with accelerated partial-wave expansion in the Coulomb gauge
Authors: Yerokhin V. A. , Harman Z. , Keitel C. H. 
Published: January 2025

Numerical calculations of the electron self-energy without any expansion in the binding nuclear field are required in order to match the rapidly advancing precision of experimental spectroscopy. For the lightest elements, particularly hydrogen, these computations are complicated by large numerical cancelations and the slow convergence of the partial-wave expansion. Methods with accelerated convergence of the partial-wave expansion have been recently put forward [V. A. Yerokhin, K. Pachucki, and V. M. Shabaev, ; J. Sapirstein and K. T. Cheng, ]. In our work we extend the accelerated-convergence methods to the previously hardly accessible region of nuclear charges Z<5 and higher excited states.

Published by the American Physical Society
2025
Longitudinal trends of high school physics students’ perceptions of experience, difficulty, and development in a long-term inquiry framework
Authors: Sigron Michal , Langley Dorothy , Dylak Stanisław , Yerushalmi Edit 
Published: January 2025

Response to the continuing call to integrate scientific inquiry activities into high school education has taken different forms varying in student ownership, physical setting, time span, and mentoring resources. Important issues are how students perceive central dimensions of their experience, and the extent to which the inquiry framework design serves to promote a sense of growth in the participants. The current research followed a group of 34 high school physics students who participated in the out-of-school Research Physics program over a 3-year period (2016–2019), gradually progressing from inquiry-oriented lab activities to an extended inquiry project under the guidance of teacher-mentors, within an instructional design of cognitive apprenticeship. The research focused on a set of 15 inquiry components, some directly related to experimental practices such as formulating inquiry questions, preparing and performing experiments, data processing using technological tools, others related to the scientific culture of presenting oral and written inquiry reports, and finally abilities of teamwork and self-regulation. Data regarding students’ perceptions of three aspects—Experience, Difficulty, and Development with respect to the inquiry components, were collected at the end of each year, using self-report questionnaires. The analysis of longitudinal trends revealed several inquiry components for which significant changes occurred in the perceptions of the three aspects, which can be mainly related to the program design. The research hypothesis regarding the relationship between the three aspects was that the perceived Development would match the levels of the perceived Experience and Difficulty for all 15 inquiry components. The quantitative analysis revealed four groups of inquiry components, only two of which aligned with the hypothesis. The quantitative findings are explained based on program design and qualitative data about student effort and ways of coping and teacher-mentor scaffolding methods.

Published by the American Physical Society
2025
Navigating the interplay between digital innovation and digital entrepreneurship: a systematic literature review and research agenda
Authors: Arora Lokesh , Singh Prakash 
Published: January 2025

PurposeGlobal businesses are witnessing a transformation in their products and services, processes and business models due to digitalisation. This trend has led to the digitalisation of innovation and entrepreneurship from the modern business perspective. The present study primarily aims to study how digital innovations shape the landscape of digital entrepreneurship and thematic perspectives.Design/methodology/approachThe present research applied a systematic literature review (SLR) method based on the PRISMA 2020 guidelines, and 47 articles were selected as the final sample size related to digital innovation and digital entrepreneurship. Though the ultimate sample size is acceptable and signifies a small sample size of 40, the choice is still justifiable as it follows the rule of thumb. Hence, “the rule of thumb” empowers the study to meaningfully contribute to the arena using the SLR method, and 40 qualified papers are an adequate lowest threshold number.FindingsThis study found that there is little investigation performed from the perspective of digital innovation and digital entrepreneurship. Prior studies researched were centred on innovation and entrepreneurship. The United Kingdom was the leading country that performed research on this domain followed by other countries such as the Netherlands, Sweden and the United States of America.Originality/valueThe present study supports the existing body of knowledge by throwing light on the association of digital innovation and digital entrepreneurship and how it further leads to the development of the digital ecosystem. It also highlights future research opportunities in the domain of digital innovation and digital entrepreneurship.
Thrive, don’t survive: building work-life balance with family support, grit and self-efficacy
Authors: Fayaz Ishret , Gulzar Farzana 
Published: January 2025

PurposeThis study investigates how emotional and instrumental family support contribute to work-life balance (WLB) among women in higher education, with a particular focus on the mediating roles of self-efficacy and grit in enhancing this balance.Design/methodology/approachUtilizing a quantitative research design, the study employed a survey methodology to gather data from women employees. The data were analyzed using partial least squares structural equation modeling (PLS-SEM) to evaluate the relationships among family support, self-efficacy, grit and work-life balance.FindingsThe results highlight the significant positive influence of both emotional and instrumental family support on work-life balance. Self-efficacy and grit serve as crucial mediators, both individually and through serial mediation, enhancing women employees' capacity to manage work and personal responsibilities effectively. The study underscores the importance of these psychological constructs in mediating the relationship between family support and work-life balance.Originality/valueThis study contributes to the literature by providing a fresh perspective on work-life balance, particularly within the context of women in higher education. It is one of the few studies to examine the dual mediating roles of self-efficacy and grit, highlighting the distinct influence of emotional and instrumental support on WLB. The findings extend social cognitive theory and conservation of resources theory by demonstrating how internal psychological resources interact with external support to enhance well-being.
Residual strength estimation of RC columns subjected to elevated temperatures from stress block parameters
Authors: Akkannavar Chaitanya Suresh , Prashanth M.H. 
Published: January 2025

PurposeIn structural fire engineering, the design of columns is done either by prescriptive approaches or by empirical equations derived from experimental research. Performance-based design is the emerging methodology for designing structures under fire, which is case-specific. There is a need to develop design equations from first principles to design/find the residual strength of the column at elevated temperatures. The present study aims to develop equations from stress block parameters to find the residual strength of reinforced concrete (RC) columns subjected to elevated temperatures.Design/methodology/approachThe stress-strain variation across the cross-section of the RC column is determined at elevated temperatures. Based on the updated stress distribution diagram, stress block parameters are derived for various depths of neutral axis (NA) and different temperatures. Using updated stress block parameters, Pu-Mu interaction curves are generated for elevated temperatures. The results are verified against conventional methods and experimental results.FindingsThe load-carrying capacity calculated from the proposed methodology is analogous to the experimental results. The methodology can be utilized to estimate the residual strength of RC columns subjected to elevated temperatures.Originality/valueThe work done here attempts to develop the equations to estimate the residual strength of the column. The work involves calculating the strength of columns subjected to fire curves.
Blockchain-based inventory pledge financing: an evolutionary game perspective
Authors: Huang Jing , Liu Jingxian , Yang Wensheng 
Published: January 2025

PurposeInventory pledge financing (IPF) serves as an effective means to address the financial constraints faced by supply chains. This study develops an IPF system involving a bank, SMEs and a third-party logistics provider (3PL) to explore the impact of varying cost structures and regulatory environments, specifically the strategic interactions within IPF system before and after the blockchain implementation. Also, provides theoretical foundations for improving the overall efficiency of financing and advancing the application of blockchain technology.Design/methodology/approachAn evolutionary game framework is employed to analyze the dynamics of financing behaviors before and after the blockchain implementation. Simulation methods are utilized to examine how different factors, including concealing costs, penalty structures and disposal prices, influence decision-making processes within IPF system.FindingsUnder IPF, the interactions of participants are shaped by asset management capabilities, reinvestment returns and penalties for fraud. As concealing costs increase, the likelihood of reaching a (loose regulation, compliant pledge) equilibrium rises. Post-blockchain implementation (IPFB), the equilibrium is influenced by default losses and compliance gains. Blockchain technology enhances regulation, effectively reducing fraud risks.Originality/valueThis study bridges significant gaps by offering a dynamic and behavioral perspective on IPF in the context of blockchain technology. Using an evolutionary game framework, the study uncovers how blockchain reshapes decision-making processes, mitigates fraud risks and enhances regulatory efficiency. By integrating cost structures and compliance incentives, it offers novel insights into behavioral shifts and systemic improvements in financing ecosystems.
Limits of ethical leadership and the role of ethics-oriented HRM system in managing Machiavellians
Authors: Agarwal Promila , Varma Arup 
Published: January 2025

PurposeThe current study investigates the significance of ethics-oriented HRM systems (EHRMS) and ethical leadership in addressing the unethical behavior of Machiavellians in professional services firms.Design/methodology/approachOur study used a multi-source, multi-wave design to investigate the impact of EHRMS and ethical leadership on the unethical behavior of Machiavellians using a sample of 364 employees.FindingsOur results reveal that EHRMS moderates the relationship between Machiavellianism and unethical behavior, while ethical leadership does not significantly moderate this relationship. Our results suggest that EHRMS has a significantly stronger impact on managing the unethical tendencies of Machiavellians than ethical leadership.Originality/valueThe study offers unique insights into the differential effects of EHRMS and ethical leadership in moderating unethical behavior among Machiavellians. The findings are also unique, as they highlight that the receptivity of ethical leadership depends on the individual differences of followers/employees.
The Effect of U.S. Country‐by‐Country Reporting on U.S. Multinationals’ Tax‐Motivated Income Shifting and Real Activities
Authors: NESSA MICHELLE L. , PERSSON ANH V. , SONG JANE Z. , TOWERY ERIN M. , VERNON MARY E. 
Published: January 2025

ABSTRACTThe Organization for Economic Cooperation and Development introduced country‐by‐country reporting (CbCR) for multinational enterprises (MNEs) to help tax authorities combat tax‐motivated income shifting. This study uses confidential U.S. tax administrative data from 2011 to 2018 to examine the effect of U.S. CbCR adoption on the tax‐motivated income shifting and real activities of U.S. MNEs. We first document that while U.S. CbCR provides the Internal Revenue Service with incremental information about the location of U.S. MNEs’ global activities relative to existing U.S. tax return disclosures, substantial overlap exists between U.S. CbCR and existing disclosures. In contrast with prior CbCR studies in cross‐country settings, we fail to find evidence of a change in U.S. MNEs’ tax‐motivated income shifting or a reallocation of real activities based on tax incentives in response to U.S. CbCR using multiple empirical approaches. Overall, our study leverages U.S. tax administrative data to provide insights into the impact of the CbCR initiative on U.S. MNEs.
What Happens to Partners Who Issue Adverse Internal Control Opinions?
Authors: BAKKE ASHLEIGH L. , COWLE ELIZABETH N. , ROWE STEPHEN P. , WILKINS MICHAEL S. 
Published: January 2025

ABSTRACTWe investigate how audit firms balance the tension between professional responsibility and client service by examining changes in partner assignments following adverse internal control opinions (ICOs). We find that partners are significantly more likely to be reassigned when they issued an adverse ICO to any of their clients in the previous year. Further, partners issuing adverse ICOs experience unfavorable changes in their client portfolios in the form of lower fees and less prestigious assignments. We find that consequences are more negative when adverse ICOs are issued to clients that are more important to the local office and that there are no consequences when partners issue continuing adverse opinions to clients they have “inherited” from an original adverse ICO partner. We also find that the consequences are stronger for partners of non‐Big 4 audit firms that are likely to be more sensitive to client service considerations. The negative portfolio effects we observe persist for at least three years, and our findings are robust to restrictions involving mandatory partner rotation and adverse ICOs that lead to client loss. Overall, our results are consistent with adverse ICO partners experiencing negative consequences as audit firms respond to client service incentives in the area of internal controls over financial reporting.
A Visualized Review of Research on Unethical Behavior in Organizations
Authors: Yuan Yiwei , Zhu Li , Li Qiao , Liu Jun , Liu Chao , Chen Chunhua 
Published: January 2025

ABSTRACTAlthough considerable efforts have been made to summarize the behavioral ethics literature, a quantitative visualization is necessary to generate an overall understanding of research on unethical behavior in organizations. Using CiteSpace, this study conducts a bibliometric review and visualizes the intellectual base of the unethical workplace behavior field. Based on a dataset of 8765 unethical‐behavior‐related publications collected from the Social Sciences Citation Index (SSCI) database from 1993 to 2023, we identify landmark studies, analyze key research themes, visualize the network of major theories, and track the evolution of research on unethical behavior in organizations via co‐citation and co‐occurrence analysis. After tracking the developmental trajectory and outlining the current state of the art, we identify potential trends in research on unethical workplace behavior and suggest some important research directions. Our bibliometric review generates a clear visualization of unethical behavior in organizations, contributing to a comprehensive understanding of this body of literature. These findings also offer valuable insights for managers seeking to address unethical behavior in their organizations and highlight implications for policymakers aiming to promote ethical workplace environments.
IGFBP2 Promotes Proliferation and Glycolysis of Endometrial Cancer by Regulating PKM2/HIF‐1α Axis
Authors: Jin Yuxi , Qi Meng , Si Lulu , Shi Xiaojing , Cai Mingbo , Fu Hanlin , Liu Yana , Guo Ruixia 
Published: January 2025

ABSTRACTEndometrial cancer (EC) is a worldwide gynecologic malignancies, with a remarking increase of incidence and mortality rates in recent years. Growing evidence indicates that glucose metabolism reprogramming is the most representative metabolic signature of tumor cells and exploring its modulatory function in EC development will promote identifying potential EC therapeutic targets. IGFBP2 is an insulin‐like growth factor binding protein which is closely associated with a variety of metabolic diseases. However, its biological role in EC and its effects on glucose metabolism remain unclear. In this study, we demonstrated that IGFBP2 was highly expressed in EC tissues and correlated with poor prognosis. Overexpression of IGFBP2 promoted proliferation and glycolysis in EC cells, whereas IGFBP2 knockdown had the opposite effect. Mechanistically, IGFBP2 directly interacted with PKM2, inducing weakened PKM2 protein degradation, and knockdown IGFBP2 expression prevented the translocation of PKM2 to the nucleus. Additionally, IGFBP2 expression was upregulated under the condition of hypoxia which directly regulated by transcriptional activation of HIF‐1α. Finally, the role of the IGFBP2/PKM2/HIF‐1α axis in EC tumor growth was confirmed in vivo using mouse xenograft models. Taken together, the current study identifies IGFBP2 as an upstream activator of PKM2‐driven proliferation and glycolysis in EC cells, providing a promising therapeutic target for EC.
Beyond opioids: The effect of prescription drug monitoring programs on non‐opioid drug prescribing
Authors: Beheshti David , Kim Bokyung 
Published: January 2025

AbstractA growing literature has examined how mandatory access prescription drug monitoring programs (MA PDMPs), laws that require providers to consider a patient's prescription history before prescribing controlled substances, affect opioid‐related outcomes. However, evidence of their impact on non‐opioid‐related prescribing is mixed. This paper investigates the effect of MA PDMPs on prescribing patterns of stimulants and benzodiazepines. Using updated difference‐in‐differences methodology, we show that MA PDMPs led to decreases in stimulant prescribing but had no significant effects on benzodiazepine prescribing. Our findings highlight that MA PDMPs do have effects on non‐opioid drug prescribing, but these effects differ substantially across drug types.