bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of antibacterial drugs in the treatment of coronavirus infection in children in real outpatient clinic practice
Authors: Ginzburg A. S. , Kiryutkina A. P. , Migacheva N. B. 
Published: July 2023

Introduction. In light of the available data on the unjustified use of antibiotics in children with acute respiratory viral infections, the frequency of prescribing antibacterial drugs to children with a new coronavirus infection in real clinical practice is of great practical and scientific interest.The aim of the study was to study the frequency of antibiotic therapy and identify factors that increase the risk of needing antibiotics in children with coronavirus infection at the outpatient stage.Materials and methods. A retrospective cross-sectional study was conducted on the basis of children's polyclinics in Samara from November 2021 to July 2022, which included a survey of parents and an analysis of outpatient records of 100 children who were under outpatient observation and treatment for COVID-19. An analysis was made of the frequency of prescribing antibiotics to them and potential factors predisposing to their prescribing to children with COVID-19. The obtained data were subjected to statistical processing using the IBM SPSS Statistics 25 program and a comparative analysis.Results. The frequency of use of antibiotic therapy according to the results of the study was 11 % and did not exceed the Russian average data (14.3 %). When analyzing the factors influencing the doctor's decision to prescribe an antibiotic to a child with coronavirus infection, the most important were a history of recurrent respiratory infections (children from the FIC group), as well as the presence of concomitant diseases and background conditions in children, primarily chronic bronchopulmonary diseases. and nervous system.Discussion. The prescription of antibiotics for children with a new coronavirus infection at the outpatient stage remains empirical due to the limitations of the use of laboratory and instrumental methods for additional examination of the child, which objectifies the likelihood of a secondary bacterial infection. Despite this, the frequency of antibiotic use according to the results of the study was 11 % and did not exceed the Russian average data (14.3 %), as well as the average frequency of antibiotic use for acute respiratory viral infections in children in the Russian Federation (21.5-23.3 %).
Strategi Islamic Branding Lembaga Fintech Syariah dalam Menarik Minat Funder dan Beneficiary: Studi pada ALAMI Fintech Sharia
Authors: Alannawa Sonia Rosta 
Published: July 2023

Data BPS tahun 2010 menyebutkan jumlah populasi umat muslim di Indonesia sebanyak 207,2 juta jiwa menjadikan Indonesia sebagai pertimbangan para produsen dalam mengembangkan potensi pangsa pasarnya. Dari banyak perusahaan startup muslim global yang telah berdiri di Indonesia, ALAMI Fintech Sharia menjadi salah satu yang banyak diminati publik karena memiliki produk investasi P2P Lending berbasis syariah dengan tingkat keberhasilan yang signifikan. Keberhasilan penerapan strategi marketing Islamic branding di ALAMI membuat penulis
tertarik meneliti hal ini. Metode penelitian menggunakan metode penelitian kualitatif. Sumber data yang digunakan berupa data primer dan data sekunder. Hasil penelitian menunjukkan strategi ALAMI diantaranya dari nama perusahaan yaitu singkatan dari Alif Lam Mim jelas membawa unsur islami, memiliki tampilan website mengenai produk syariah yang transparan, memberi banyak tawaran promosi pembiayaan berbasis islami yang berlandaskan pada fatwa DSN-MUI, dan menggunakan akad pembiayaan syariah. Ketertarikan para Funder dan Beneficiary dalam melakukan P2P Lending Sharia banyak dipengaruhi atas strategi Islamic branding yang diterapkan ALAMI meliputi segi keberhasilan pembiayaan, pelunasan pembiayaan yang tepat waktu dan jaminan uang kembali. Dengan demikian peneliti menarik kesimpulan bahwa strategi Islamic Branding yang diterapkan oleh PT. ALAMI Fintech Sharia bisa memudahkan dan berpotensi menarik minat serta kepercayaan para Funder dan Beneficiary dalam melakukan pembiayaan.
Culture of Hoffa fat pad mesenchymal stem/stromal cells on microcarrier suspension in vertical wheel bioreactor for extracellular vesicle production
Authors: Otahal Alexander , Kramer Karina , Neubauer Markus , Lacza Zsombor , Nehrer Stefan , De Luna Andrea 
Published: July 2023

Abstract
Background
Mesenchymal stromal cells (MSCs) are increasingly employed in regenerative medicine approaches for their immunomodulatory and anti-inflammatory properties, which are encoded in their secretome including extracellular vesicles (EVs). The Hoffa fat pad (HFP) located harbours MSCs that could assist in tissue homeostasis in osteoarthritic joints. Intraarticular injection therapies based on blood products could modulate the populations of released HFP-MSC-EVs in a quantitative manner.
Methods
To obtain amounts of HFP-MSC-derived EVs that allow pre-clinical evaluation, suitable EV production systems need to be developed. This work investigates the release of EVs from primary HFP-MSCs cultivated in a 3D environment using microcarrier suspension culture in a vertical wheel bioreactor in comparison to conventional 2D culture. To simulate an intraarticular blood product therapy, cultures were treated with citrate-anticoagulated platelet-rich plasma (CPRP) or hyperacute serum (hypACT) before EV collection. HFP-MSC-EVs are enriched via ultrafiltration and characterised via Western Blot, nanoparticle tracking analysis in scatter as well as fluorescence mode.
Results
Blood product supplementation elevated metabolic activity as determined via XTT assay over the course of 14 days. 3D culture resulted in a roughly 100-fold EV yield compared to 2D culture and elevated number of EVs released per cell. Total protein content correlated with the EV concentration. While typical EV marker proteins such as CD9, CD63 or Alix were detected in total protein extracts, CD9 and CD73 colocalised on individual EVs highlighting their cell origin. The type of blood product treatment did not affect the size or concentration of EVs obtained from HFP-MSCs.
Conclusions
HFP-MSCs proliferate in presence of human blood products indicating that animal serum in culture media can be avoided in the future. The culture of HFP-MSCs in the employed bioreactor was successfully used to generate quantities of EVs that could allow evaluation of HFP-MSC-EV-mediated effects in pre-clinical settings.
Effectiveness of Virtual Training in the Post-Pandemic Period Using the Kirkpatrick Model
Authors: Suraj Neethu , N Abhishek 
Published: July 2023

Abstract
Teaching and training through online tools were used by most of the (HEIs) Higher Education Institute worldwide during covid-19 to cater to the needs of students who stay far away from universities/colleges. After the pandemic, the virtual model of education and training became a trend. The students and teachers are also more used to this trend and which is giving more opportunities to both learners and instructors. One of the notable benefits of virtual teaching and learning platform is that it provides a flexible environment to gain knowledge, skills, and attitude simultaneously along with formal off-line education. This directly influences the employability of outgoing UG and PG students. In this paper, an attempt has been made to assess the perceived effectiveness of virtual training and education among outgoing graduates under the Kirkpatrick model.
The Relationshıp Between Ghrelin And Iron Metabolism In Beta Thassemia Major Patients
Authors: SARKAYA Nihan Cansel , KURTOĞLU Ayşegül UĞUR , GÖÇER Mesut 
Published: July 2023

Abstract
Studies on HIF2α, hepcidin, and ferroportin molecules in beta thalassemia majör (β-TM) patients show that there are disorders in these pathways. In recent years, studies conducted in patients with iron deficiency anemia have investigated the relationship between ghrelin hormone and iron metabolism. In this study, we aimed to contribute to the etiopathogenesis of this disease by examining the changes in ghrelin hormone levels in patients with β-TM. 52 β-TM and 23 controls were included in our study. Cell blood counts, biochemical parameters, HIF2α, hepcidin and ghrelin levels were studied from blood samples taken from the volunteers. Serum HIF2α, hepcidin and ghrelin levels were measured by ELISA method. Erythrocyte indexs, serum total bilirubin, direct bilirubin, iron, unsaturated iron binding capacity, total iron binding capacity and ferritin levels showed significant differences between the two groups (p < 0.05). There was no significant difference between the two groups in serum HIF2α and hepcidin levels. When the patient group and healthy controls were compared, serum ghrelin levels were found to be significantly higher in the patient group (p < 0.05). There was a significant positive correlation between serum ghrelin and ferritin levels in the patient group (r = 0.401) (p < 0.05). It suggested that high ghrelin levels may have an important role in the regulation of impaired iron metabolism in patients with β-TM. The positive correlation between serum ghrelin levels and ferritin suggested that serum iron may have an important role in ghrelin synthesis, and that increased ghrelin levels may be a factor that increases ferritin synthesis.
Water-binding strength as regulator of extracellular-matrix mechanics enables detection of swelling-associated biophysical alterations using MRI
Authors: Kollert Matthias R. , Krämer Martin , Brisson Nicholas M. , Schemenz Victoria , Tsitsilonis Serafeim , Qazi Taimoor H. , Fratzl Peter , Vogel Viola , Reichenbach Jürgen R. , Duda Georg N. 
Published: July 2023

Abstract
Altered hygroscopic properties of the extracellular matrix (ECM), such as related to exudation, are characteristic for various pathologies including inflammation in injury, inherent swelling, or proteoglycan (PG) dysregulation. Mechanical properties of the ECM are key characteristics of various cell niches, capable of defining cell phenotype and fate, or of storing pathological information. Dehydration is known to alter ECM mechanics, but the role of the binding of water to the ECM remains unclear. Our data illustrate that the proportion of loosely to strongly bound water is a distinctive ECM property that regulates its mechanics and they suggest a crucial role of PGs for elastic and viscous characteristics. Osmolality and loosely bound water determine dynamic ECM properties. This understanding may pave the ground to diagnose related pathological tissue alterations non-invasively using combined MR T1 and T2* mapping. Eventually, the strength of water binding may be utilized as controlled cell-niche property to guide cell behavior.
Results of the DAPA-CKD trial and their impact on clinical practice
Authors: Bilchenko O.V. 
Published: July 2023

Chronic kidney disease (CKD) is a growing medical and social problem in the world. Data from population base stu­dies demonstrate an increase in the prevalence of CKD and mortality. One of the causes is an increase in the number of patients with diabetes. Another reason is the limited ability to prevent the progression of the loss of kidney function. The first studies with dapagliflozin, such as DECLARE-TIMI 58 in patients with type 2 diabetes, showed a slowing of the progression of CKD to end-stage renal disease. The DAPA-CKD trial included patients with both type 2 diabetes and those without diabetes with an estimated glomerular filtration rate of 25 to 75 ml/min/1.73 m2 and albuminuria. The DAPA-CKD trial was terminated prematurely by independent monitors because of dapagliflozin overwhelming placebo. The primary endpoint, which included a sustained decrease in estimated glomerular filtration rate ≥ 50 %, end-stage renal disease, or death from renal or cardiovascular causes, was 39 % lower in the dapagliflozin group than in the placebo group. The effect of dapagliflozin on the primary endpoint was also similar among patients with dia­betic nephropathy, glomerulonephritis, ischemic or hypertensive CKD, and CKD of other or unknown cause. Also, the effect of dapagliflozin was the same regardless of concomitant cardiovascular diseases or chronic heart failure. All-cause mortality was 31 % lower among patients who received dapagliflozin at a dose of 10 mg. Dapagliflozin also significantly reduced the frequency of sudden decline in kidney function in CKD patients by 32 %. According to the results of a post-hoc analysis of the DAPA-CKD trial, compared to placebo, dapagliflozin reduced the frequency of hospitalizations due to cardiac causes, kidney and urinary tract diseases, metabolic and nutritional disorders, and oncological problems. This effect of dapagliflozin was independent of baseline type 2 diabetes. Based on the DAPA-CKD trial, dapagliflozin was approved by the Food and Drug Administration for use in reducing the risk of worsening kidney function, kidney failure, cardiovascular death, and heart failure hospitalization in adults with CKD.
ДОСЛІДЖЕННЯ СПРЯМОВАНИХ І ХВИЛЬОВИХ ПАРАМЕТРІВ АНТЕНИ ПОВЕРХНЕВИХ ХВИЛЬ
Authors: СЕМЕНОВ Андрій , ГРОМИК Олександр 
Published: July 2023

Об’єктом дослідження роботи є процес випромінювання електромагнітних хвиль антеною поверхневих хвиль. Предметом дослідження є спрямовані та хвильові параметри антени поверхневих хвиль. Запропонована в роботі антена поверхневих хвиль із ребристою сповільнюючою структурою має класичну геометричну конфігурацію та працює в смузі робочих частот від 7,25 ГГц до 7,75 ГГц. Її габаритні розміри - ширина 38 мм, висота 136 мм, довжина 455 мм. Збудження антени здійснено E-секторіальною прямокутною рупорною антеною. Як сповільнююча структура була обрана плоска ребриста структура, що представляє собою періодично повторювальні канавки шириною 2 мм і глибиною 6 мм з ребрами товщиною 2 мм і періодом повторення 4 мм. Поверхневий імпеданс сповільнюючої структури носить індуктивний характер і має величину j1,65 Ом, j1,75 Ом і j1,87 Ом відповідно для мінімальної, середньої та максимальної частоти робочого діапазону. У роботі отримані результати електричних розрахунків і математичного моделювання спрямованих і хвильових параметрів антени поверхневих хвиль в робочому діапазоні частот. При мінімальній довжині хвилі λ = 38,7 мм, що відповідає частоті 7,75 ГГц ширина амплітудної діаграми спрямованості 21,9°, рівень бокових пелюсток 0,33, коефіцієнт спрямованої дії 59,94, вхідний опір 53,96 Ом, коефіцієнт відбиття 0,038 і коефіцієнт стоячої хвилі 1,07. При максимальній довжині хвилі λ = 41,4 мм, що відповідає частоті 7,25 ГГц, ширина амплітудної діаграми спрямованості 25,8°, рівень бокових пелюсток 0,32, коефіцієнт спрямованої дії 39,93, вхідний опір 47,49 Ом, коефіцієнт відбиття -0,027 і коефіцієнт стоячої хвилі 1,05. В розробленій антені поверхневої хвилі реалізовані оптимальні значення зворотних втрат і коефіцієнта стоячої хвилі. Перевагою запропонованої антени є простота конструкції, сталість вхідного опору на рівні 50 Ом та якісне узгодження в робочому діапазоні частот.
Financial Law Procedures to reduse Informal housing in Iraq compared with other states experiences
Authors: جاسم زينب منذر , غائب فضيلة عباس 
Published: July 2023

The problem of informal housing is one of the problems that most countries of the world face, and if their formulas and conditions differ, they assume deviations from the idea of the right to adequate housing guaranteed by constitutions for all individuals, as this right should be available in a way that guarantees them a free and dignified life, especially the most vulnerable groups in society with Limited income and others which fall within this description.
And that the problem of random housing does not hide its effects in any aspect of life. It creates the hotbeds of crime, poverty and social distortion in the structure of our societies. Therefore, it is better for each country to consider finding or creating different solutions to get rid of this problem. Perhaps the most important of these solutions finds its way in the procedures of financial law. Such as allocating the necessary funds within the scope of the general budget, and activating the role of some financial tools of the state, such as the residential domain to eliminate them and other solutions that can emerge in this regard. Hence, the idea of this research came to shed light on these measures guided by the experiences of some Arab countries such as Egypt, and they will serve as an example. Guide the Iraqi legislator to address the problem of random housing in Iraq.
Quarry
Authors: Franco Tanis 
Published: July 2023

<p>Spaces are not exterior to bodies. They influence and affect the way bodies exist in the world. A quarry is an unnatural place within a natural territory. At any moment, it can be abandoned. A body is not separate from the spaces it inhabits. They exist together, in a mutual state of interrelation and instability.</p>
<p><em>Quarry</em> relays a year in the life of a body in transition as it changes with other bodies; human, animal, and mineral. It examines queer social spaces and contested natural spaces, asking how they affect each other. Using evocative metaphor and refreshing language, these poems make bodily experience new.</p>
<p>Tanis Franco eschews traditional narratives of the queer and transgender body, bringing nuanced ideas to an ongoing literary and philosophical conversation. They create a strong sense of location and landscape, interweaving place with sensual language and impeccable craft to create a unique and distinctive voice. </p>
PEMBELAJARAN MENULIS PUISI MENGGUNAKAN METODE EXPERIENTIAL LEARNING BERBANTUAN MEDIA LAGU PADA PESERTA DIDIK KELAS X SMK PASUNDAN 1 BANDUNG
Authors: Khaerunisa Kamiliya , M.Z.M. Dindin , Setiawan  
Published: July 2023

ABSTRACT
This research is motivated by the low writing skills of students, which is caused by the lack of variation in teaching methods used by educators. The use of varied and creative teaching methods can make students more active and motivated during learning activities. One creative method that can be used is the experiential learning method. The objectives of this research are to test the author's ability to plan, implement, and evaluate poetry writing lessons using the experiential learning method for students of class X at Pasundan 1 Vocational High School in Bandung; to test the ability of students in class X at Pasundan 1 Vocational High School in writing poetry according to its structural elements; to determine the differences in poetry writing between the experimental class using the experiential learning method and the control class using the discussion method; and to test the effectiveness of the experiential learning method in poetry writing lessons for students of class X at Pasundan 1 Vocational High School in Bandung. In its implementation, the author used a quantitative method. The data obtained consisted of pretest and posttest scores of students from both the experimental and control classes. The findings of this research are as follows: 1) The author was able to plan, implement, and evaluate poetry writing lessons using the experiential learning method, with an average planning score of 3.7 and an average implementation score of 4, which falls into the category of very good. 2) The students' ability in writing poetry showed improvement. In the experimental class, the average pretest score of 57 increased to a posttest score of 77. In the control class, there was an improvement with an average pretest score of 36 increasing to a posttest score of 55. 3) There is a significant difference between the experimental class and the control class. 4) The experiential learning method is effective in teaching poetry writing. This is evidenced by the Mann-Whitney test results, which revealed a sig. value of 0.000 < 0.05. Based on the above explanation, the experiential learning method can be considered as an effective alternative teaching method for writing poetry.
Keywords: teaching method, experiential learning, writing, poetry.
An Analysis of Idiomatic Expressions Found in Adele’s Selected Lyrics Songs
Authors: Yalase Revalda 
Published: July 2023

This study is being carried out in attempt to discover the idiomatic terms utilized in the songs of Adele. This study employed qualitative research that focused on content or document analysis. In this study, the songs from Adele were used as the data source. Makkai's theory was used to the data analysis (1972). The researchers searched the internet for the music album, looked for the script lyrics, listening, and typing. Beyond that, data analysis included reading, evaluating, recognizing, and classifying the sorts of idiomatic idioms present in song lyrics, and finally making conclusions. After evaluating the data, the researchers discovered three idiomatic phrases portrayed in the lyrics of the songs: phrasal verb idioms, tournure idioms, and incorporating verb idioms.
Keywords : idioms,song lyrics,Adele
The Use of Code Mixing In Beauty Content Creators of Lula And Myra at Youtube Channels
Authors: Siti Fatimah Al Islamiah  
Published: July 2023

ABSTRACT
Sociolinguistics is a branch of linguistics that studies the relationship between language and society. Everyone has their own personal style of language when they communicate with others. In this study, the research investigated about code-mixing that found in YouTube Channels. The data is taken from the youtube channels of one beauty influencer named Lula and Myra. The aims of this study were to find out the types of code-mixing category used by Lula and Myra utterance in their videos. The researcher used Hoffman (1991) theory to reveal this study. The research applied qualitative descriptive method to analyze the types of code-mixing. The method of data collection is the researchers watched and written every utterance in the video and then categorized it into three characteristics of code mixing. The result of this research there are (7) intra-sentential mixing, (4) intra-lexical mixing, and (3) involving a change of pronunciation.
Análisis económico del control de la tensión arterial en pacientes que se realizan hemodiálisis, diálisis peritoneal cíclica ambulatoria y diálisis peritoneal automatizada
Authors: Sanango Reinoso Wilmer Stalin , Herrera Ordoñez Jorge Oswaldo , Puertas Azanza Soraya , Sevilla Rodríguez Carmen Maricela 
Published: July 2023

Introducción: El control de la tensión arterial (TA), es un objetivo fundamental, en los pacientes con enfermedad renal crónica estadio 5D, ya que la hipertensión y la hipotensión causan efectos adversos en la calidad de vida del paciente y predisponen al aumento del riesgo cardiovascular. El objetivo del presente estudio fue realizar un análisis económico de la prescripción de antihipertensivos en un grupo de pacientes en terapia sustitutuva de la función renal.
Métodos: Se trata de un estudio transversal, realizado en el servicio de hemodiálisis del hospital “José Carrasco Arteaga”. Las variables fueron: tipo de diálisis, sexo, uso de antihipertensivos, tipo de antihipertensivos y costo. La muestra fue no probabilística.
Resultados: Se analizan 174 pacientes, 73 (41.95%) en programa de hemodiálisis (HD), 80 (45.98%) en programa de diálisis peritoneal manual (DP) y 21 (12.07%) en diálisis peritoneal automatizada (DPA). Fueron 74% de hombres en HD, 39 casos (48.7%) en DP, 12 casos (57.14%) en DPA. El uso de antihipertensivos en HD fue del 84%, en DP fue del 86% y en DPA fue del 86%. El costo de antihipertensivos fue en HD 12.5 ± 8.7 USD, en DP 15.7 ± 22.4 y en DPCA 16.4 ± 18.6 USD P>0.05.
Conclusión: el uso de antipertensivos en este grupo de estudio fue en mas del 84% en las diferentes modalidades de diálisis, sin diferencia estadítica en el análisis de costo.