bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and Management of Vocal Complications after Chondrolaryngoplasty
Authors: Nuyen Brian , Qian Z. Jason , Rakkar Meher , Thomas James P. , Erickson‐DiRenzo Elizabeth , Sung C. Kwang 
Published: December 2022

ObjectiveTransfeminine patients (transwomen/feminine nonbinary folks assigned male at birth) can undergo chondrolaryngoplasty (“tracheal shave”) to feminize their neck appearance. While isolated cases of vocal complications have been reported following the procedure, aggregated outcomes have not been quantitatively studied. We present acoustic and stroboscopic data to describe a patient cohort with vocal complications after chondrolaryngoplasty and discuss reparative surgical technique.MethodsSubjective and objective data, including videostroboscopy, were collected from patients with voice complaints after chondrolaryngoplasty. Dislocated anterior commissures were reconstructed with feminization laryngoplasty. Postoperative voice data were recorded and statistically compared to preoperative data using paired t‐tests.ResultsOn consecutive chart review, of the 94 transfeminine women with prior outside history of chondrolaryngoplasty, 27 (29%) reported chronic postoperative hoarseness, deepened pitch, or loss of upper register. On endoscopy, short, lax vocal folds with persistent anterior glottic gap and phase asymmetry were commonly noted; anterior commissure dislocation was confirmed in‐office by using needle localization through absent thyroid cartilage. After open resuspension of the anterior commissure with feminization laryngoplasty, post‐repair modal‐speaking, minimum, and maximum fundamental frequencies (F0) increased on average by 7, 8, and 5 semitones, respectively (p < 0.01), when compared to pre‐repair values. On average, perioperative maximum phonation time did not change significantly (p = 0.15). Average self‐assessment of vocal femininity increased by 48% (p < 0.01).ConclusionAnterior commissure dislocation should be suspected with signs of vocal impairment after chondrolaryngoplasty. Following proper diagnosis, resuspension of the anterior commissure via feminization laryngoplasty approach can be an effective reparative technique.Level of EvidenceThis work represents a 2011 OCEBM Level 4 evidence as a case series Laryngoscope, 133:2301–2307, 2023
What can we learn from the Baduanjin rehabilitation as COVID‐19 treatment?: A narrative review
Authors: Zhu Zhenggang , Pan Xiaoyan , Zhong Faping , Tian Jun , Ong Marilyn Li Yin 
Published: December 2022

AbstractAimTo understand Baduanjin rehabilitation therapy in mild COVID‐19 patients.DesignA narrative review.MethodsA literature search for COVID‐19 and Baduanjin treatments was conducted on Chinese and English electronic databases: China National Knowledge Infrastructure, Wanfang Data, Embase, PubMed, Scopus, Science Direct, Ebscohost, SPORTDiscus and ProQuest.ResultsTwelve studies on the Baduanjin rehabilitation for COVID‐19 patients have been included. We acknowledged the considerable published research and current clinical practice using Baduanjin for COVID‐19 treatment in the following areas: anxiety, depression, insomnia, lung function rehabilitation, immunity and activity endurance.ConclusionThe use of Baduanjin as adjuvant therapy for COVID‐19 patients' rehabilitation is still limited, therefore, more clinical studies are needed to confirm its efficacy.
On two‐dimensional weakly singular fractional partial integro‐differential equations and dual Bernstein polynomials
Authors: Sayevand Khosro , Mirzaee Farshid , Masti Imman 
Published: December 2022

AbstractThis article presents an efficient numerical scheme based on some properties of dual Bernstein operational matrices for a class of linear and nonlinear two‐dimensional weakly singular fractional partial integro‐differential equations (WSFPID). A novel property of the suggested scheme is the conversion of the WSFPID into an algebraic system of equations. The corresponding linear and nonlinear system of equations are solved by well‐known Newton–Raphson scheme. Convergence and an upper error bound, of the scheme are also analyzed. Finally, by providing several examples and reviewing the numerical results and comparing them with other available methods, we show that the mentioned method has acceptable accuracy and efficiency. The main important applications of the proposed scheme is that it can be applied on linear as well as nonlinear problems and can be applied on higher order partial differential equations too. Also, with a small number of bases, we can find a reasonable approximate solution.
Neighborhood socioeconomic differences in BMI: The role of fast‐food outlets and physical activity facilities
Authors: van Diepen Rianne J. , van Erpecum Carel‐Peter L. , Tabak Demi , van Zon Sander K.R. , Bültmann Ute , Smidt Nynke 
Published: December 2022

AbstractObjectiveThe goal of this study was to investigate the association between neighborhood socioeconomic status (NSES) and BMI and to what extent this association is moderated by availability of fast‐food (FF) outlets and pay‐for‐use physical activity (PA) facilities.MethodsBaseline data of adults in Lifelines (N = 146,629) were linked to Statistics Netherlands and a register using geocoding to compute, respectively, NSES (i.e., low, middle, high) and the number of FF outlets and PA facilities within 1 km of the residential address. Multivariable multilevel linear regression analyses were performed to examine the association between NSES and BMI. Two‐way and three‐way interaction terms were tested to examine moderation by FF outlets and PA facilities.ResultsParticipants living in low NSES areas had a higher BMI than participants living in high (B [95% CI]: 0.76 [0.65 to 0.87]) or middle NSES areas (B [95% CI]: 0.40 [0.28 to 0.51]), independent of individual socioeconomic status. Although two‐ and three‐way interactions between NSES, FF outlets, and PA facilities were significant, stratified analyses did not show consistent moderation patterns.ConclusionsPeople living in lower NSES areas had a higher BMI, independent of their individual socioeconomic status. The study found no clear moderation of FF outlets and PA facilities. Environmental factors that may mitigate NSES differences in BMI should be the subject of future research.
Temperature‐induced structural change of integrin αvβ3 receptor and its interaction with the RGD peptide ligand
Authors: Wang Anqi , Yue Kai , Wei Yiang , Zhong Weishen , Zhang Genpei 
Published: December 2022

AbstractThe structural change of receptor protein at high temperatures is one of the factors affecting the targeting ability of ligand‐installed nanocarriers for combined therapy of hyperthermia and drug delivery. In this study, the binding behaviors and mechanisms of integrin αvβ3 receptor and the arginine‐glycine‐aspartic acid (RGD) peptide ligand at high temperatures were investigated both theoretically and experimentally. The structural parameters of integrin αvβ3 at different temperatures and the interaction forces between the RGD peptide and integrin αvβ3 at different binding sites were calculated by molecular dynamics simulation. Fourier transform infrared spectroscopy, energy dispersive spectroscopy, ultraviolet–visible absorption spectroscopy, and atomic force microscopy were used to analyze the structural changes of integrin αvβ3 and to measure the ligand‐receptor interaction. Results show that the number of hydrogen bonds decreased and the secondary structure of integrin αvβ3 changed with the increase in temperature, indicating the denaturation of integrin αvβ3. The structural stability of the integrin αv subunit was better than that of the integrin β3 subunit at high temperatures. The interaction between the RGD peptide and integrin αvβ3 weakened as the temperature increased because the structure of the integrin αvβ3 binding site became more flexible and the corresponding calcium ions were shed from the binding site. The strongest interaction force was exhibited at the binding site of the integrin β3 subunit at 310 K while it was found at the binding site of the integrin αv subunit at higher temperatures, owing to the smaller structure deformation of the integrin αv subunit.
Achieving sustainable population: Fertility decline in many developing countries follows modern contraception, not economic growth
Authors: Götmark Frank , Andersson Malte 
Published: December 2022

AbstractThe human population is projected to increase by 2.4 billion to 2100, endangering, for example, food security and biodiversity. Population growth depends strongly on fertility level, lowering of which is often assumed to depend on economic growth. Here we test this hypothesis using data from 136 developing countries, 1970–2014. We formed four country groups at different initial economy, and used graphical analyses, with estimates of variation. Falling fertility rates 1970–2000 showed little or no association with economy (GDP or household consumption). Fertility decreased regardless of whether the economy grew, was stagnant, or declined. But falling fertility was closely associated with increasing use of modern contraception, which was largely independent of changes in economy. Fertility decline hence was not caused by economic development, but followed contraceptive use. Family planning programs, with advice on family size and modern contraception, offer promising routes to sustainably low fertility where it has not yet been achieved.
Enhanced Pseudocapacitance of the LaNiO3 Perovskite in p‐Phenylenediamine as Redox‐Active Electrolyte
Authors: Goel Priyanshu , Mishra Sunita , Deep Akash 
Published: December 2022

AbstractPerovskite oxides are well known for their excellent properties such as catalytic activity, oxygen ion mobility and structure stability. These properties make it a most suitable material for energy storage devices like fuel cells, batteries and supercapacitors. In the present work, LaNiO3 perovskite was synthesized using the sol‐gel method and its morphological parameters were characterized by XRD, SEM and FTIR. The anion‐intercalated pseudocapacitive nature of LaNiO3 powder was studied in 2M KOH as well as in the mixture of 2M KOH with p‐phenylenediamine (PPD) as an alkaline aqueous and redox‐active electrolyte respectively. Electrochemical performance characteristics cyclic voltammetry (CV), galvanostatic charge discharge (GCD) and electrochemical impedance spectroscopy (EIS) of LaNiO3 has shown pseudocapacities of 300.60 Fg−1 at a scan rate of 5 mV s−1 and 440 F g−1 at a current density of 1 A g−1 in KOH+PPD electrolyte. Furthermore, a symmetrical pseudocapacitor has been fabricated using LaNiO3 as electrode active material with 2M KOH+PPD as an redox‐active electrolyte. The device delivered an energy density of 13.75 Wh kg−1 at the power density of 500 W kg−1 at a potential of 1 V. This excellent performance may be due to the synergic effect of both redox active electrode (LaNiO3) and electrolyte (KOH+PPD) that together demonstrated a great combination for high performance pseudocapacitors for future applications.
Functional biomaterials for osteoarthritis treatment: From research to application
Authors: Lei Yang , Zhang Qingfei , Kuang Gaizheng , Wang Xiaochen , Fan Qihui , Ye Fangfu 
Published: December 2022

AbstractOsteoarthritis (OA) is a common disease that endangers millions of middle‐aged and elderly people worldwide. Researchers from different fields have made great efforts and achieved remarkable progress in the pathogenesis and treatment of OA. However, there is still no cure for OA. In this review, we discuss the pathogenesis of OA and summarize the current clinical therapies. Moreover, we introduce various natural and synthetic biomaterials for drug release, cartilage transplantation, and joint lubricant during the OA treatment. We also present our perspectives and insights on OA treatment in the future. We hope that this review will foster communication and collaboration among biological, clinical, and biomaterial researchers, paving the way for OA therapeutic breakthroughs.
Experimental Consideration on Influence of Magnetic After Effect on Gap Magnetic Field and Applicability of Conventional Hysteresis Models for Particle Accelerator Electromagnets
Authors: Hane Yoshiki , Urata Tomoki , Onchi Yoshitake , Sugahara Kengo , Nakamura Kenji , Ishi Yoshihiro 
Published: December 2022

AbstractTo further improve the control accuracy of the magnetic field generated by particle accelerator electromagnets, it is necessary to model not only the magnetic hysteresis behavior but also the magnetic after effect, which has never been studied in the previous literature. In this paper, the gap magnetic field of an accelerator magnet was measured under various excitation conditions to acquire the experimental data required for modeling. Consequently, it was clarified that the magnetic after effect may influence the magnetic hysteresis behavior. Moreover, it was accordingly indicated that a novel modeling technique is required in addition to the conventional hysteresis models developed in the electric machine field. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Assessment of deep aquifer groundwater quality in a geographically unique climatic region of Southern Western Ghats, India using water quality indices
Authors: N Kannan , A Krishnakumar , Joseph Sabu , Chacko Shiju 
Published: December 2022

AbstractWater quality index (WQI) models are generally used in hydrochemical studies to simplify complex data into single values to reflect the overall quality. In this study, deep groundwater quality in the Chittur and Palakkad Taluks of the Bharathapuzha river basin of Kerala, India, was assessed by employing the WQI method developed by the Canadian Council of Ministers of the Environment (CCME). The assessment of overall water quality is indispensable due to the specific characteristics of the study area, such as geography, climate, over‐drafting, and prevalent agricultural practices. Forty representative samples were collected from the study area for monsoon (MON) and pre‐monsoon (PRM) seasons. The results showed a general increase of contents from MON to PRM. The major cations were spread in the order Ca2+>Na+>Mg2+>K+ and the anions HCO3−>Cl−>CO32− based on their relative abundance. Among various parameters analysed, alkalinity and bicarbonate levels during MON were comparatively high, which is indicative of carbonate weathering, and 90% of the samples failed to meet the World Health Organization (WHO, 2017)/Bureau of Indian Standards (BIS, 2012) drinking water guidelines. The CCME WQI analysis revealed that nearly 50% of the samples during each season represented good and excellent categories. The samples in the poor category comprised 10% in MON and 15% in PRM. The overall WQI exhibited 15% of poor category samples as well. The spatial depiction of CCME WQI classes helped to expose zones of degraded quality in the centre to eastward parts. The spatial and temporal variations of CCME WQI classes and different physicochemical attributes indicated the influence of common factors attributing to the deep groundwater quality. The study also revealed inland salinity at Kolluparamba and Peruvamba stations, where agricultural activities were rampant with poor surface water irrigation.
Improved cancer immunotherapy strategies by nanomedicine
Authors: Guo Shuai , Feng Jie , Li Zongheng , Yang Sugeun , Qiu Xiaozhong , Xu Yikai , Shen Zheyu 
Published: December 2022

AbstractCancer immunotherapy agents fight cancer via immune system stimulation and have made significant advances in minimizing side effects and prolonging the survival of patients with solid tumors. However, major limitations still exist in cancer immunotherapy, including the inefficiency of immune response stimulation in specific cancer types, therapy resistance caused by the tumor microenvironment (TME), toxicities by the immune imbalance, and short lifetime of stimulator of interferon genes (STING) agonist. Recent advances in nanomedicine have shown significant potential in overcoming the obstacles of cancer immunotherapy. Several nanoscale agents have been reported for cancer immunotherapy, including nanoscale cancer vaccines impacting the STING pathway, nanomaterials reprogramming TME, nano‐agents triggering immune response with immune checkpoint inhibitor synergy, ferroptosis‐mediated and indoleamine‐2,3‐dioxygenase immunosuppression‐mediated cancer immunotherapy, and nanomedicine‐meditated chimeric antigen receptor‐T‐cell therapy. Herein, we summarize the major advances and innovations in nanomedicine‐based cancer immunotherapy, and outline the opportunities and challenges to integrate more advanced nanomaterials into cancer immunotherapy.This article is categorized under:
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Therapeutic Approaches and Drug Discovery > Emerging Technologies
NLO electroweak corrections to multi-boson processes at a muon collider
Authors: Bredt Pia M. , Kilian Wolfgang , Reuter Jürgen , Stienemeier Pascal 
Published: December 2022

Abstract
We present results on NLO electroweak (EW) corrections to multiple massive boson production processes at a future muon collider. Inclusive cross sections with $$ \mathcal{O} $$
O
(α) corrections for processes for up to four bosons in the final state as well as differential distributions for HZ production are computed for $$ \sqrt{s} $$

s

= 3, 10 and 14 TeV by using FKS subtraction in the NLO EW automated Monte-Carlo framework WHIZARD+RECOLA. Large logarithmic effects due to collinear ISR and EW virtual correction factors as well as the impacts of an energy cut on hard photons are discussed with an emphasis on the properties of Higgsstrahlung. The potential of a proposed muon collider for studying physics of the EW sector is underlined by the EW corrections significantly affecting observables for processes at high energies and boson multiplicities.
Membrane nucleation rates from holography
Authors: Arcos Maite , Fischler Willy , Pedraza Juan F. , Svesko Andrew 
Published: December 2022

Abstract
Membrane nucleation, a higher dimensional analog of the Schwinger effect, is a useful toy model for vacuum decay. While a non-perturbative effect, the computation of nucleation rates has only been accomplished at weak coupling in the field theory. Here we compute the nucleation rates of spherical membranes using AdS/CFT duality, thus naturally including the effects of strong coupling. More precisely, we consider the nucleation of spherical membranes coupled to an antisymmetric tensor field, a process which renders the vacuum unstable above a critical value of the field strength. We analyze membrane creation in flat and de Sitter space using various foliations of AdS. This is accomplished via instanton methods, where the rate of nucleation is dominated by the semi-classical on-shell Euclidean action. Our findings generalize the holographic Schwinger effect and provide a step toward holographic false vacuum decay mediated by Coleman-De Luccia instantons.
Tsunami Runup and Inundation in Tonga from the January 2022 Eruption of Hunga Volcano
Authors: Borrero Jose C. , Cronin Shane J. , Latu’ila Folauhola Helina , Tukuafu Pupunu , Heni Nikolasi , Tupou Ana Maea , Kula Taaniela , Fa’anunu Ofa , Bosserelle Cyprien , Lane Emily , Lynett Patrick , Kong Laura 
Published: December 2022

AbstractOn January 15th, 2022, at approximately 4:47 pm local time (0347 UTC), several weeks of heightened activity at the Hunga volcano 65 km northwest of Tongatapu, culminated in an 11-h long violent eruption which generated a significant near-field tsunami. Although the Kingdom of Tonga lies astride a large and tsunamigenic subduction zone, it has relatively few records of significant tsunami. Assessment activities took place both remotely and locally. Between March and June 2022, a field team quantified tsunami runup and inundation on the main populated islands Tongatapu and Eua, along with several smaller islands to the north, including the Ha’apai Group. Peak tsunami heights were ~ 19 m in western Tongatapu, ~ 20 m on south-eastern Nomuka Iki island and ~ 20 m on southern Tofua, located ~ 65 km S and E and 90 km N from Hunga volcano, respectively. In western Tongatapu, the largest tsunami surge overtopped a 13–15 m-high ridge along the narrow Hihifo peninsula in several locations. Analysis of tide gauge records from Nukualofa (which lag western Tongatapu arrivals by ~ 18–20 min), suggest that initial tsunami surges were generated prior to the largest volcanic explosions at ~ 0415 UTC. Further waves were generated by ~ 0426 UTC explosions that were accompanied by air-pressure waves. Efforts to model this event are unable to reproduce the timing of the large tsunami wave that toppled a weather station and communication tower on a 13 m-high ridge on western Tongatapu after 0500 UTC. Smaller tsunami waves continued until ~ 0900, coincident with a second energetic phase of eruption, and noted by eyewitnesses on Tungua and Mango Islands. Despite an extreme level of destruction caused by this tsunami, the death toll was extraordinarily low (4 victims). Interviews with witnesses and analysis of videos posted on social media suggest that this can be attributed to the arrival of smaller ‘pre tsunami’ waves that prompted evacuations, heightened tsunami awareness due to tsunami activity and advisories on the day before, the absence of tourists and ongoing tsunami education efforts since the 2009 Niuatoputapu, Tonga tsunami. This event highlights an unexpectedly great hazard from volcanic tsunami worldwide, which in Tonga’s case overprints an already extreme level of tectonic tsunami hazard. Education and outreach efforts should continue to emphasize the ‘natural warning signs’ of strong ground shaking and unusual wave and current action, and the importance of self-evacuation from coastal areas of low-lying islands. The stories of survival from this event can be used as global best practice for personal survival strategies from future tsunami.
Einsatz von Simulationspersonen zur Prüfung von Handlungskompetenz im Bereich der Kinderschutzmedizin im Dritten Abschnitt der Ärztlichen Prüfung
Authors: Steglich Jonas , Hempel Linn , Jaspers Susanna , Stoevesandt Dietrich , Weber Marko , Kunze Christian , Weihrauch-Blüher Susann , Kühnöl Caspar , Woydt Lina 
Published: December 2022

ZusammenfassungIn der COVID-19-Pandemie war die Durchführung des Dritten Abschnitts der Ärztlichen Prüfung mit Simulationspersonen möglich. Simulationen ermöglichen die standardisierte Prüfung medizinischer Handlungskompetenz entsprechend den Lernzielen des Nationalen Kompetenzbasierten Lernzielkatalogs. Die Prüfung von Szenarien der Kinderschutzmedizin erscheint zweckmäßig, um die Aufmerksamkeit angehender Ärztinnen und Ärzte für Verdachtsmomente möglicher Kindesmisshandlung zu schärfen. Der vorliegende Fall berichtet über die Simulation eines nichtakzidentellen Traumas im Kindesalter.