bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic relevance of temporal muscle thickness compared to functional scales in patients with high-grade glioma
Authors: Klingenschmid Julia , Krigers Aleksandrs , Schön Victoria , Pinggera Daniel , Kerschbaumer Johannes , Grams Astrid E. , Thomé Claudius , Freyschlag Christian F. 
Published: May 2023

Abstract
Background: GBM research is constantly assessing potential valuable prognostic biomarkers to better understand the disease and prognosticate future outcomes. Measuring temporalis muscle thickness (TMT) has appeared to be a promising new surrogate marker for skeletal muscle mass and sarcopenia, which further indicates frailty and predicts overall survival (OS). The aim of this study was to determine its usefulness as a prognostic marker in patients with high-grade glioma compared to functional status scales.
Methods: TMT was measured in preoperative axial T1 weighted contrast enhanced magnetic resonance images in 277 patients who received surgical treatment of newly diagnosed WHO III and IV gliomas in our institution between 2015 and 2020. Clinical frailty scale (CFS) and Karnofsky performance score (KPS) were assessed preoperatively and during a follow-up visit.
Results: Female gender has shown significant correlation with TMT, while TMT did not correlate with preoperative and follow-up functional scores, age, WHO classification, IDH mutation, MGMT promotor methylation, EGFR and ATRX expression or 1p/19q co-deletion. No significant prognostic value of TMT could be shown in 6, 12 and 24 months OS, while changes in CFS and KPS proved to have a significant impact.
Conclusions: Only female gender, but no other clinical, histological or molecular marker showed any interrelation with TMT. Functional scores outclass measuring TMT as a reliable prognostic factor for predicting OS in patients with high-grade glioma.
Effective methylation triage of a screening population with HPV infection and/or abnormal cytology results in China
Authors: Zhou Guan-Nan , Gu Yuan-Yuan , Wang Qing , Ding Jing-Xin , Hua Ke-Qin 
Published: May 2023

Abstract
Background The S5-methylation test, as an alternative classifier to cytology and HPV16/18 genotyping to triage cervical squamous intraepithelial lesions, has not been widely validated in Asian countries. Herein, we compared S5 methylation to HPV16/18 and cytology to detect cervical high-grade squamous intraepithelial lesion (HSIL) in a screening population who with either HPV infection or abnormal cytology results or both of them, derived from a multi-central clinical trial of 2246 Chinese participants. We matched all ≥ HSIL + cases (n = 468) with ≤LSIL controls (n = 468) to analyze the effectiveness of methylation. Methylation of S5 was quantified by pyrosequencing, blinded to cytology, histological and initial HPV results.Results The S5 methylation could distinguish women with ≥ HSIL + from women with ≤LSIL at a high area under the curve (AUC) of 0.80 (95% CI 0.74–0.85). The sensitivity of S5 methylation (at 2.85 cutoff) for ≥ HSIL + was 76.1% (95% confidence interval [CI] 71.7–79.2) was higher than HPV16/18 sensitivity (64.9%, 95% CI 58.3–71.7, P = 0.039) or cytology (48.9%, 95% CI 42.8–53.2, P < 0.001). At this cutoff, the specificity of S5 for ≥ HSIL + was (79.9%, 95% CI 76.2–84.9), higher than HPV16/18 (44.8%, 95% CI 40.1–49.4, P < 0.001) and cytology (54.6%, 95%CI 50.7–57.9, P < 0.001). In addition, S5 methylation could provide predictive information about progression in specific population in follow-up period.Conclusion S5 methylation classifier with high sensitivity and specificity exceeded HPV16/18 or cytology for detecting women with ≥ HSIL + in a screening Chinese population with HPV infection and/or abnormal cytology results. Furthermore, S5 methylation is a potential classifier for predicting progression.
WITHDRAWN: Lanternfish Diaphus spp. specimens of a DNA barcoding survey of the mesopelagic micronekton communities of the New Caledonia and Wallis-and-Futuna EEZ
Authors: Borsa Philippe , Lagrange Damien , Millet Laurent , Vourey Elodie 
Published: May 2023

Abstract

This document includes 25 plates of annotated photographs of lanternfish Diaphus spp. specimens collected during cruises ESSCHA, NECTAlis, PUFFAlis and WALLAlis of R.V. Alis in the Coral Sea, the Fiji Basin, and the Pacific Ocean around Wallis-and-Futuna Islands. Specimens were grouped by operational taxonomic unit, defined (OTU) as the cluster to which they belonged in a phylogenetic tree of sequences of a portion of the CO1 gene. Species assignment was initially based on the morphological identification of reference specimens, i.e., particularly-well preserved specimens that exhibit the diagnostic characters mentioned in diagnoses and identification keys from the published literature. In several instances, the same species was represented by distinct OTUs.
Sensorimotor Behavior in Individuals with Autism Spectrum Disorder and Their Unaffected Biological Parents
Authors: Bojanek Erin K. , Kelly Shannon E. , Schmitt Lauren M. , White Stormi P. , Sweeney John A. , Sprenger Andreas , Unruh Kathryn E. , Mosconi Matthew W. 
Published: May 2023

Abstract
Background: Sensorimotor impairments are common in autism spectrum disorder (ASD) and evident in unaffected first-degree relatives, suggesting that they may serve as important endophenotypes associated with inherited risk. We tested the familiality of sensorimotor impairments in ASD across multiple motor behaviors and effector systems and in relation to parental broader autism phenotypic (BAP) characteristics.
Methods: Fifty-eight autistic individuals (probands), 109 parents, and 89 control participants completed tests of manual motor and oculomotor control. Sensorimotor tests varied in their involvement of rapid, feedforward control and sustained, sensory feedback control processes. Subgroup analyses compared families with at least one parent showing BAP traits (BAP+) and those in which neither parent showed BAP traits (BAP-).
Results: Probands with BAP- parents (BAP- probands) showed rapid manual motor and oculomotor deficits, while BAP+ probands showed sustained motor impairments compared to controls. BAP- parents showed impaired rapid oculomotor and sustained manual motor abilities relative to BAP+ parents and controls. Atypical rapid oculomotor impairments also were familial.
Limitations: Larger samples of ASD families including greater samples of probands with BAP+ parents are needed. Genetic studies also are needed to link sensorimotor endophenotype findings directly to genes.
Conclusions: Results indicate rapid sensorimotor behaviors are selectively impacted in BAP- probands and their parents and may reflect familial liabilities for ASD that are independent of familial autistic traits. Sustained sensorimotor behaviors were affected in BAP+ probands and BAP- parents reflecting familial traits that may only confer risk when combined with parental autistic trait liabilities. These findings provide new evidence that rapid and sustained sensorimotor alterations represent strong but separate familial pathways of ASD risk that demonstrate unique interactions with mechanisms related to parental autistic traits.
High-pressure polymorphs of ferroan dolomite: Possible host structures for carbon in the lower mantle
Authors: Martirosyan Naira S. , Efthimiopoulos Ilias , Jahn Sandro , Lobanov Sergey S. , Wirth Richard , Reichmann Hans-Josef , Koch-Müller Monika 
Published: May 2023

Abstract
In this study, we investigated four different ferroan dolomite samples using in situ Raman spectroscopy and powder X-ray diffraction (XRD) at pressures up to 48 GPa and room temperature. Our results show that the transition from Dolomite-I (Dol-I) to Dolomite-II (Dol-II) occurs above 13–16 GPa, and the transition pressure depends on the composition of the solid solution. Compression above 32–35 GPa results in the appearance of Dolomite-IIIc (Dol-IIIc) or Dolomite-IIIb (Dol-IIIb). In the high-pressure XRD study, we found that the XRD patterns of Ca0.97(Mg0.77Fe0.23Mn0.03)(CO3)2 (xFe = 0.23, Ank23) can be indexed as Dol-IIIc at 44 GPa, while the rhombohedral Dol-IIIb structure matches better with the XRD patterns of the xFe = 0.40 (Ank40) and 0.64 (Ank64) solid solutions. Additionally, in the Raman spectra of the Fe-richest sample (Ank64), we observed an abrupt frequency downshift of the CO3-stretching vibrations between 40–42 GPa, which may reflect a pressure-induced Fe2+ spin transition.
We further investigated two samples with xFe = 0.19 (Ank19) and 0.23 (Ank23) at high pressure and high temperatures, up to at least 2600 K. The experiments revealed that the unquenchable Dol-IIIc structure could be a stable high-pressure/high-temperature polymorph in ferroan dolomite up to at least 2600 K.
SCS-CN methodology further modified
Authors: Verma Sangeeta , Verma Ravindra Kumar 
Published: May 2023

Abstract

This paper further modifies soil conservation service curve number (SCS-CN) based on the concept of adjusting the rainfall in accordance with rain duration and considering the initial abstraction (Ia) as a fraction of rainfall for runoff estimation. The former yields Model M3 and its explicit form with constant parameter λ = 0.2 is designated as Model M4. Model M5 couples both the concepts and thus all these models are the advanced versions. The applicability of all the five models is tested using a large number of rainfall-runoff events (25,502) derived from 53 U.S. Department of Agriculture-Agricultural Research Service watersheds. Models M3–M5 performed better than Models M1 and M2. Model performance is evaluated by employing six statistical measures, namely, root mean square error, mean absolute error, normalized root mean square error, Nash–Sutcliffe coefficient (%), percent bias, RSR, n(t), and several grading criteria. Results show Model M5 to have performed the best of all in both calibration and validation largely due to its incorporating the impact of rain duration and allowing Ia to vary with rainfall, which is close to reality and not accounted for in any other models considered in this study.
Deep Learning-reconstructed Parallel Accelerated Imaging for Knee MRI
Authors: Park Chankue , Lee Sang-Min , Kim MinWoo , Lee Dongeon , Kim Kang Soo , Jeong Hee Seok , Choi Min-Hyeok 
Published: May 2023

Background:
Deep learning (DL) can improve image quality by removing noise from accelerated MRI.

Objective:
To compare the quality of various accelerated imaging applications in knee MRI with and without DL.

Methods:
We analyzed 44 knee MRI scans from 38 adult patients using the DL-reconstructed parallel acquisition technique (PAT) between May 2021 and April 2022. The participants underwent sagittal fat-saturated T2-weighted turbo-spin-echo accelerated imaging without DL (PAT-2 [2-fold parallel accelerated imaging], PAT-3, and PAT-4) and with DL (DL with PAT-3 [PAT-3DL] and PAT-4 [PAT-4DL]). Two readers independently evaluated subjective image quality (diagnostic confidence of knee joint abnormalities, subjective noise and sharpness, and overall image quality) using a 4-point grading system (1-4, 4=best). Objective image quality was assessed based on noise (noise power) and sharpness (edge rise distance).

Results:
The mean acquisition times for PAT-2, PAT-3, PAT-4, PAT-3DL, and PAT-4DL sequences were 2:55, 2:04, 1:33, 2:04, and 1:33 min, respectively. Regarding subjective image quality, PAT-3DL and PAT-4DL scored higher than PAT-2. Objectively, DL-reconstructed imaging had significantly lower noise than PAT-3 and PAT-4 (P <0.001), but the results were not significantly different from those for PAT-2 (P >0.988). Objective image sharpness did not differ significantly among the imaging combinations (P =0.470). The inter-reader reliability ranged from good to excellent (κ = 0.761–0.832).

Conclusion:
PAT-4DL imaging in knee MRI exhibits similar subjective image quality, objective noise, and sharpness levels compared with conventional PAT-2 imaging, with an acquisition time reduction of 47%.
Determination of Antithyroid Drug Propylthiouracil with Ru (III) in
Pharmaceutical Formulations and its Characterization
Authors: Sharma Mukul , Koty Afraim 
Published: May 2023

Background:
Background: Sulfur serves as a versatile element and an essential constituent of pharmaceutical
industries, natural compounds, proteins, and biological systems. One of the fundamental
constituents of sulfur is thiouracil, which forms several derivatives, including 6-
methylthiouracil, 6-methyl-2-thiouracil, and 6-propylthiouracil. These derivatives act as effective
chelating agents and can form complexes with metal ions.

:
Compared with other metals, ruthenium possesses unique chemical properties that make it an ideal
therapeutic agent. Therefore, this study reports on the propylthiouracil: Ru(III) complex, considering
these essential facts.

Methods:
An equimolar amount of ruthenium trichloride 3.34 x 10-5 M was added to various aliquots
ranging from 0.4 mL to 8.8 mL of 3.26 x 10−5 M propylthiouracil. The volume was adjusted
to 10 mL with double distilled water. After letting the solution stand for 10 min, we recorded the
absorbance of different sets at λmax 376 nm. The Beer-Lambert's law graph demonstrated linearity
in the concentration range of 3.18 x101 μgmL-1 to 7.96 x102 μgmL-1, with a linear regression
equation of Y = 0.0354 + 0.1109 X. We determined the effective molar absorptivity (ε) to be
6.609 x 102 Lmole-1 cm-1, and the relative standard deviation (RSD %) was ± 0.34%.

Results:
At room temperature, a yellow-colored complex of propylthiouracil: Ru(III) was formed
within 10 min, with a λmax of 376 nm and constant color intensity for 24 h. We confirmed and
characterized the formed complex using FTIR, ESR, 1HNMR, thermal analysis, magnetic susceptibility,
and powder X-ray.

Conclusion:
This approach is notable for its precision, accuracy, rapidity, cost-effectiveness, and
applicability in tablet form. The novel propylthiouracil: Ru(III) complex offers several advantages,
including stability, low absorbance, and no interference with water-soluble ions, eliminating
the need for an organic solvent to extract the reaction product. Therefore, this approach
could be recommended for quality control in the pharmaceutical industry.
Analisis Hubungan Hasil Belajar Siswa terhadap Karakter “Menghargai Prestasi” di SMPN 5 Muaro Jambi
Authors: Milyani Vetty , Sutomo Wenny 
Published: May 2023

Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara hasil belajar siswa terhadap angket karakter “menghargai prestasi” di SMPN 5 Muaro Jambi. Penelitian ini menggunakan jenis penelitian survei. Populasi dalam penelitian ini adalah siswa kelas VIII SMPN 5 Muaro Jambi, dengan sampel yaitu kelas VIII A dan VIII E sebanyak 45 responden. Instrumen yang digunakan berupa soal pilihan ganda dan angket karakter siswa. Teknik analisis data dalam penelitian ini menggunakan teknik analisis parametrik, yaitu dengan melakukan uji asumsi atau uji prasyarat berupa uji normalitas dan linearitas serta melakukan uji hipotesis berupa uji korelasi. Pengujian hipotesis yang digunakan yaitu uji korelasi product moment. Hasil penelitian menunjukkan bahwa terdapat hubungan antara angket karakter siswa dengan hasil belajar siswa, baik itu kelas VIII A atau kelas VIII E. Hal ini dibuktikan dengan nilai sig 0,05. Oleh karena kedua variabel memiliki korelasi, maka Ha diterima.
Analisis Proses Bernalar Siswa dalam Memecahkan Masalah Matematika di SMP Muhammadiyah 6 Dau Malang
Authors: Primantari Yulia , Nusantara Toto , Bambang Irawan Edy 
Published: May 2023

Penelitian ini bertujuan untuk mendeskripsikan proses bernalar matematika siswa kelas VIII SMP Muhammadiyah 6 Dau Malang dalam memecahkan masalah matematika. Jenis dan pendekatan yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan subjek yaitu siswa kelas VIII SMP Muhammadiyah 6 Dau Malang sebanyak 27 siswa. Data diperoleh dari pemberian Tes dan Wawancara. Hasil penelitian proses bernalar siswa ini menunjukkan bahwa (1) menyajikan pernyataan matematika, siswa mampu menyajikan pernyataan matematika dengan benar yaitu terbukti pada kegiatan siswa membuat model matematika dari soal cerita yang diberikan; (2) mengajukan dugaan, siswa dapat menentukan strategi penyelesaian soal dengan benar, hal ini terbukti pada kegiatan siswa pada saat menentukan strategi dengan cara eliminasi untuk memperoleh salah satu nilai; (3) melakukan manipulasi, siswa dapat mengerjakan soal menggunakan konsep matematika yang relevan serta melakukan perhitungan sampai selesai dan memperoleh hasil yang benar, hal ini terbukti pada kegiatan siswa dalam menyelesaikan masalah, siswa mengerjakan soal dengan menggunakan konsep matematika yang relevan yaitu konsep SPLD, siswa juga melakukan perhitungan sampai selesai dengan hasil yang benar; (4) menyimpulkan, menunjukkan bahwa siswa belum mampu menarik kesimpulan dari kegiatan yang dilakukan dengan baik. Siswa belum mampu menuliskan kesimpulan akhir dari jawaban yang diperoleh. Mereka hanya selesai sampai perhitungan akhir tanpa memberikan kesimpulan atas jawaban yang diperoleh.
Pengaruh Model Pembelajaran Brainstorming terhadap Hasil Belajar Siswa Kelas VIII pada Materi Kubus
Authors: Junita Popi , Juwita Hariani , Siswanto Jemiyo 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Brainstorming terhadap hasil belajar matematika siswa kelas VIII SMP Negeri 1 Tanjung Sakti PUMU Tahun Pelajaran 2017/2018. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 1 Tanjung Sakti PUMU Tahun Pelajaran 2017/2018 yang berjumlah 165 siswa, sampel yang diambil dalam penelitian ini secara acak. Maka terpilihlah kelas VIII 1 sebagai kelas kontrol sebanyak 30 siswa, kelas VIII 2 sebagai kelas eksperimen sebanyak 35 siswa dengan jumlah keseluruhan penelitian ini 65 siswa. Pengumpulan data diambil dengan metode tes dalam bentuk uraian, sedangkan analisis data menggunakan deskriptif kuantitatif yaitu uji hipotesis dengan rumus t (statistik uji t). Setelah diadakan penelitian maka didapat yaitu 2,41 1,67 maka Ho ditolak Ha diterima. Sehingga dapat disimpulkan bahwa ada pengaruh model pembelajaran Brainstorming terhadap hasil belajar matematika siswa kelas VIII SMP Negeri 1 Tanjung Sakti PUMU Tahun Pelajaran 2017/2018.
Pengaruh Model Pembelajaran Process Oriented Guided Inquiry Learning (POGIL) Berbantuan Lembar Kerja Peserta Didik Terintegrasi Nilai-Nilai Keislaman terhadap Kemampuan Komunikasi Matematis
Authors: Yana Novi , Masykur Rubhan , Ganda Putra Fredi 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Process oriented Guided Inquiry Learning (POGIL) berbantuan lembar kerja peserta didik yang terintegrasi nilai-nilai KeIslaman terhadap kemampuan komunikasi matematis. Populasi penelitian kuasi eksperimen dengan posttest-only control design adalah 116 peserta didik kelas VII MTs Al-Hikmah Bandar Lampung tahun pelajaran 2018/2019. Metode yang digunakan observasi, wawancara, dokumentasi, dan tes. Teknik pengumpulan data yang digunakan adalah tes. Analisis data yang digunakan adalah uji anava satu jalan dengan sel sama. Hasil penelitian menunjukkan terdapat pengaruh kemampuan komunikasi matematis peserta didik yang mendapatkan model pembelajaran Process Oriented Guided Inquiry Learning (POGIL) berbantuan lembar kerja peserta didik yang terintegrasi pada nilai-nilai KeIslaman daripada peserta didik yang memperoleh model pembelajaran konvensional.
Teleworking to Support Accommodation, Inclusion, and Health of Aging Workers: Protocol for a Study to Design, Validate, and Test a Reflective Application Guide
Authors: Lecours Alexandra , Hong Quan Nha , Maclure Joanie , Bédard-Mercier Roxanne , Vincent Claude , Boucher Normand , Lord Marie-Michèle 
Published: May 2023

BackgroundAging workers constitute a growing population in many countries and form an indispensable and qualified resource, especially in the context of the labor shortage. Despite work’s many benefits for individuals, organizations, and societies, it also presents several risks and challenges that may lead to occupational injuries. Thus, rehabilitation professionals and managers working with this emerging and unique clientele during their return to work after an absence often lack the tools and skills to support them, especially in the changing world of work that includes the rise of telework. Indeed, as an increasingly present work arrangement, telework has the potential to be used as an accommodation modality that can facilitate inclusion and healthy participation in the workplace. However, the implications of this topic for aging workers require study.ObjectiveThis paper presents the protocol of a study that aims to develop a reflective telework application guide to support the accommodation, inclusion, and health of aging workers after an absence from work. Specifically, this study will (1) explore the experience of aging workers, managers, and rehabilitation professionals regarding telework and its impact on accommodation, inclusion, and health; (2) use a validated logic model to design a reflective application guide; and (3) test and evaluate the guide.MethodsFollowing a 3-phase developmental research design, individual interviews with aging teleworkers, managers, and rehabilitation professionals will enable the collection of qualitative data to be used in generating a logic model of levers and good practices, leading to the creation of a reflective application guide. Validation of this guide by workers and managers to measure its acceptability and applicability in daily life will precede its implementation.ResultsData collection began in spring 2023 and initial results are expected in fall 2023. This study aims to generate a concrete tool—namely, the reflective telework application guide—that rehabilitation professionals could use to support managers and aging workers during their return to work through the healthy use of telework. All phases of the study include conducting dissemination activities to share the results of the project and increase its sustainability potential (ie, publication through social networks, podcasts, conferences, and scientific publications).ConclusionsAs the first of its kind, this project aims to produce innovative impacts at several levels, including practical, scientific, and societal impacts. In addition, the results will provide healthy solutions to the labor shortage in a changing world of work, where digital and teleworking are becoming increasingly important.International Registered Report Identifier (IRRID)DERR1-10.2196/46114
Characteristics of auroral electron precipitation at 1 geomagnetic latitude 67° over Tromsø
Authors: Tesfaw Habtamu W. , Tesfaw Habtamu W , Virtanen Ilkka I , Aikio Anita T 
Published: May 2023

Key Points:
• We use EISCAT UHF ISR data to study the 1-100 keV electron
precipitation at 6 66.7° MLAT observed during 21 years.
• The auroral electron precipitation occurrence rate as observed by the
radar reaches70% in the 05–06 MLT sector of the main auroral oval.
• Electron precipitation with 50–100 keV peak energies is more common
than with 30–50 keV peak energies after 06 MLT