bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical activity of TGF-β inhibitor vactosertib in combination with imatinib in desmoid tumors: a multicenter phase 1/2 study
Authors: Ahn Jin-Hee , Lee Jeeyun , Park Changhee , Beom Seung-Hoon , Kim Seung Hyun , Lee Young Han , Yun Kum-Hee , Kim Jeung Eun , Baek Wooyeol , Han Yoon Dae , Kim Sang Kyum , Ryu Hyang Joo , Jung Inkyung , Lee JooHee , Yoon Hong In , Kim Hyo Song 
Published: September 2023

Abstract
BACKGROUND To determine to the activity and safety of TGF-β inhibitor, vactosertib in combination with imatinib in patients with desmoid tumors.PATIENTS AND METHODS In this investigator-initiated, open-label, multicenter, phase I/II trial, patients with desmoid tumors not amendable to locoregional therapies (surgery and/or radiotherapy) or with disease progression following at least one treatment were enrolled. Participants were administered 400 mg imatinib daily in combination with vactosertib (5 days on and 2 days off, twice a day) every 28 days. In phase I, the vactosertib dose was set at 100 mg (level − 1) and 200 mg (level 1) to determine the recommended phase II dose. Phase II assessed the efficacy, with the primary endpoint being progression-free rate (PFR) at 16 weeks. The tolerability of the vactosertib and imatinib combination and pharmacokinetic parameters were also evaluated.RESULTS Twenty-eight patients were enrolled with a median follow-up of 20.7 months. Of the 27 patients evaluated, 7 (25.9%) achieved a confirmed partial response and 19 (70.4%) were stable. The PFR at 16 weeks and 1 year were 96.3% and 81.0%, respectively. Treatment-naïve patients had longer PFS compared to those with 1–2 or 3 prior treatment modalities (1 year PFS 100% vs 90% vs 25%, P = 0.017). The most toxicities were mild to moderate myalgia (n = 10, 37%), anemia (n = 10, 37%), and nausea (n = 9, 33.3%). Common grade 3–4 toxicities included neutropenia (n = 6, 22.2%) and anemia (n = 5, 18.5%).CONCLUSIONS Vactosertib and imatinib combination was well-tolerated, with promising clinical activity in patients with progressive, locally advanced desmoid tumors. This is the first study investigating a novel target agent, a TGF-β inhibitor, in this rare and difficult-to-treat desmoid tumor.
Nb2C and Nb2CO2 MXenes as Anodes in Li-ion Batteries: A Comparative Study by First-Principles Calculations
Authors: Santoy-Flores R. , Escamilla H. N. Fernández , Páez-Ornelas J. I. , Perez-Tijerina E. G. , Guerrero-Sánchez J. , Ponce-Perez R. , Takeuchi N. , Moreno-Armenta Ma. Guadalupe 
Published: September 2023

Abstract

Resume:
The new generation of Li-ion batteries is based on integrating 2D materials into the electrodes to increase energy density while reducing charging time and size. The two-dimensional transition metal carbides or nitrides (MXene) materials offer ideal electronic properties such as metallic behavior, low energy barriers for Li-ion diffusion, and structural stability. This study focuses on Nb2C and Nb2CO2 MXenes, which have shown promising Li-storage capacity, especially the oxidized phase. By using Density Functional Theory (DFT) and thermodynamics criteria, we study the Li intercalation process in both MXenes. Results show that the Li intercalation process in the oxidized phase is more stable. Also, the Li diffusion barriers are 35 meV and 250 meV for the bare and oxidized phase, because of the strong interaction between Li ions and O functional groups. Nb2C and Nb2CO2 MXenes deliver a maximum gravimetric theoretical capacity of 275 and 233 mAh/gr, respectively, with a stable performance.
Characterization of the Sweet Pitaya (Stenocereus thurberi) Fruit Peel Transcriptome: Analysis of Genes Playing a Role in Cuticle Biosynthesis and Identification of Reference Genes
Authors: García-Coronado Heriberto , Hernández-Oñate Miguel-Angel , Tafolla-Arellano Julio-César , Burgara-Estrella Alexel-Jesús , Tiznado-Hernández Martín-Ernesto 
Published: September 2023

Abstract

Background
Cactus (Cactaceae) are plants distributed across arid regions of America with ecological and economic value. One trait that allows the cactus to survive in desert ecosystems is its cuticle, which limits water loss in dry conditions. Nevertheless, the mechanism of cuticle biosynthesis has yet to be described for cactus. Stenocereus thurberi is a cactus endemic from the Sonoran desert, which produces a fruit named sweet pitaya. Transcripts from S. thurberi published in databases are scarce, and no gene expression analysis has been carried out for this species. This study reports for first time the de novo assembly and characterization of the sweet pitaya peel transcriptome.
Results
Two hundred forty-three million of 80–150 base pairs reads with at least 25 of quality in the Phred score were used to get the assembly. The transcriptome includes 174,449 transcripts with an N50 value of 2,110 bp and 85.4% of completeness. Out of the total transcripts, 122,234 (70.07%) were classified as coding RNA, and 43,391 were classified as long non-coding RNA. Functional categorization analysis suggests a response to stress and an active cuticle biosynthesis in fruit pitaya peel. The genes elongation factor 1-alpha (StEF1a), α-tubulin (StTUA), and polyubiquitin 3 (StUBQ3) are reliable reference genes for accurate normalization of gene expression analysis in this specie through qRT-PCR. The cuticle biosynthesis transcripts cytochrome p450 family 77 subfamily A (StCYP77A), Gly-Asp-Ser-Leu motif lipase/esterase 1 (StGDSL1), and ATP binding cassette transporter family G member 11 (StABCG11) showed higher expression at the early stages of fruit development and ripening suggesting an active cuticle compound biosynthesis and transport.
Conclusions
This is the first transcriptome developed in the S. thurberi specie. Further, housekeeping genes suitable for gene expression analysis by qRT-PCR in this specie are reported for first time. The information generated will help to analyze the molecular mechanism of cuticle biosynthesis and another relevant metabolic pathway in S. thurberi and other cactus species. Understanding the role of cuticle in the adaptation to arid environments could help design technologies to ensure fleshy fruit production in the context of the increase in water scarcity for agriculture predicted for the following years.
Nonlinear Normal Modes of Highly Flexible Beam Structures Modelled under the SE(3) Lie Group Framework
Authors: Bagheri Amir Kamyar , Sonneville Valentin , Renson Ludovic 
Published: September 2023

Abstract
This work presents a shooting algorithm to compute the periodic responses of geometrically nonlinear structures modelled under the Special Euclidean (SE) Lie group formulation. The formulation is combined with a pseudo-arclength continuation method, while special adaptations are made to ensure compatibility with the $SE$ framework. Nonlinear normal modes (NNM) of various two-dimensional structures including a doubly-clamped beam, a shallow arch, and a cantilever beam are computed. Results are compared with a reference displacement-based FE model with von Kármán strains. Significant difference is observed in the dynamic response of the two models in test cases involving large degrees of beam deformation and rotation. Differences in the contribution of higher order modes substantially affect the frequency-energy dependence and the nonlinear modal interactions observed between the models. It is shown that the SE model, owing to its exact representation of the beam kinematics, is better suited at adequately capturing complex nonlinear dynamics compared to the von Kármán model.
A Novel Study on Antioxidant Activity and Catalytic Reduction of
Methylene Blue using ZnO Nanoparticles Synthesized via the Middle Part
of Walnut Shell (Juglans regia) Extract
Authors: Jafari Pouya , Meshkatalsadat Mohammad Hadi , Pouramiri Behjat 
Published: September 2023

Abstract:
The synthesized ZnO nanoparticles were characterized using UV-Vis spectroscopy, SEM,
XRD, FTIR, and TEM analysis. The catalytic activity of the prepared green catalyst ZnO nanoparticles
was also investigated in the dye methylene blue (MB) decomposition. The catalytic decomposition reaction
completed within 20 minutes, demonstrating the excellent catalytic properties of ZnO nanoparticles
in reducing MB.
This research describes the green synthesis of ZnO nanoparticles using an extract of the middle part of a
walnut shell (Juglans regia).
The antioxidant activities (radical capture capacity) of the synthesized ZnO nanoparticles were evaluated
by the 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) assay at different ZnO nanoparticle concentrations,
and the radical capture activity was achieved at IC50 = 146.32 μg / mL.
The radical capture activity was achieved at IC50 = 146.32 μg / mL.
The biosynthesis of ZnO nanoparticles was caused by hydroxide precipitation at room temperature after
calcination at 450°C.
One-pot Multicomponent Synthesis of Hydrazinyl Thiazoles Bearing an
Isatin Moiety in Aqueous Medium
Authors: Sim Kooi-Mow , Chung Li-Ping , Tan Kit-Lin , Tan Yee-Ting , Kee Xin-Lee , Teo Kah-Cheng 
Published: September 2023

Abstract:
Isatin-derivatives are an important class of nitrogen-containing heterocyclic compounds in
organic synthesis. On the other hand, 1,3-thiazoles are 5-membered heterocyclic compounds containing
nitrogen and sulphur atoms. Hydrazinyl thiazoles are often prepared through the classical condensation
of aldehydes or ketones with thiosemicarbazide to yield thiosemicarbazones, which will then
undergo heterocyclization with phenylacyl bromides to give the corresponding hydrazinyl thiazoles.
Nowadays, multi-component reactions (MCRs) are considered the most powerful tool in organic synthesis.
The use of water as a green solvent in organic synthesis is one of the goals of green chemistry.
In this study, a series of new hydrazinyl thiazoles 3a-3u bearing an isatin moiety were synthesized in
good yield via a one-pot three-component condensation reaction of isatins with thiosemicarbazide and
phenyl acyl bromides in water under reflux condition. All the synthesized compounds were characterized
by IR, 1D-NMR, 2D-NMR and LC/MS spectral data.
Network Pharmacological Study of the Active Ingredient of Panax
Notoginseng Saponins for the Treatment of Lung Cancer by Inhibiting
AKR1C3
Authors: Wei Yue-Zi , Yang Mei-Zhu , Yuan Wei 
Published: September 2023

Background:
Lung cancer is the malignancy with the second highest diagnostic rate and the
leading cause of cancer-related death.

Objective:
This study aims to investigate the potential mechanism and molecular targets of Panax notoginseng
saponins (PNS) in inhibiting lung cancer through network pharmacology.

Methods:
Pharmacodynamic targets of each compound of PNS were searched from TargetNet, SwissTargetPrediction,
and BatMan-TCM databases. Next, the differential expression genes (DEGs) in
lung cancer were obtained from the Gene Expression Omnibus (GEO) database and screened by R
package. Later, the STRING 11.0 database was utilized to analyze the protein-protein interaction (PPI)
network of common targets of PNS-lung cancer, clusterProfiler to perform gene ontology (GO) annotation,
and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for the
common targets, and Cytoscape 3.8.0 to construct and analyze the "ingredient-target" network for the
common targets of PNS-lung cancer.

Results:
A total of 154 potential pharmacodynamic targets of PNS, 2399 DEGs of lung cancer-related
diseases, and 21 common targets of PNS-lung cancer were obtained by database search and screening.
The 21 common targets were mainly involved in biological processes (such as small molecule metabolism
and cytokine production) and were major components of cellular structures (such as neuronal cell
bodies and membrane rafts). Besides, these targets could function as carboxylic ester hydrolases, G
protein-coupled amine receptors, and oxidoreductase. They were mainly enriched in 14 signaling
pathways, like neuroactive ligand-receptor interaction, regulation of lipolysis in adipocytes, and calcium
signaling pathway. Furthermore, the molecular docking results revealed that aldo-keto reductase
family 1 member C3 (AKR1C3) and melanin metabolic enzyme (MME) may be direct targets of ginsenoside
Rg1 and notoginsenoside R2.

Conclusion:
Our study showed that ginsenosides inhibit the progression of lung cancer through multiple
targets and pathways. More importantly, PNS may treat lung cancer by directly inhibiting AKR1C3.
Vitamin E and Diabetic Foot Ulcers
Authors: Karakousis Nikolaos D. , Pyrgioti Elisavet E. , Georgakopoulos Petros N. , Karagiannakis Dimitrios S. , Papanas Nikolaos 
Published: September 2023

Abstract:
This narrative mini-review discusses vitamin E levels in subjects with diabetic foot ulcers (DFUs). Vitamin E may be reduced in subjects with DFUs, but this finding is inconsistent. Its administration appears to benefit patients with DM, delaying the onset of complications, including DFU. There is also evidence that it may promote DFU healing. Nonetheless, further studies are required to confirm these promising results and estimate vitamin E administration's cost-effectiveness
Network Propagation-based Identification of Oligometastatic Biomarkers in Metastatic Colorectal Cancer
Authors: Jin Qing , Yu Kexin , Zhang Xianze , Huo Diwei , Zhang Denan , Liu Lei , Xie Hongbo , Liang Binhua , Chen Xiujie 
Published: September 2023

Background:The oligometastatic disease has been proposed as an intermediate state between primary tumor and systemically metastatic disease, which has great potential curable with locoregional therapies. However, since no biomarker for the identification of patients with true oligometastatic disease is clinically available, the diagnosis of oligometastatic disease remains controversial.Objective:We aim to identify potential biomarkers of colorectal cancer patients with true oligometastatic states, who will benefit most from local therapy.Methods:This study retrospectively analyzed the transcriptome profiles and clinical parameters of 307 metastatic colorectal cancer patients. A novel network propagation method and network-based strategy were combined to identify oligometastatic biomarkers to predict the prognoses of metastatic colorectal cancer patients.Results:We defined two metastatic risk groups according to twelve oligometastatic biomarkers, which exhibit distinct prognoses, clinicopathological features, immunological characteristics, and biological mechanisms. The metastatic risk assessment model exhibited a more powerful capacity for survival prediction compared to traditional clinicopathological features. The low-MRS group was most consistent with an oligometastatic state, while the high-MRS might be a potential polymetastatic state, which leads to the divergence of their prognostic outcomes and response to treatments. We also identified 22 significant immune check genes between the high-MRS and low- MRS groups. The difference in molecular mechanism between the two metastatic risk groups was associated with focal adhesion, nucleocytoplasmic transport, Hippo, PI3K-Akt, TGF-β, and EMCreceptor interaction signaling pathways.Conclusion:Our study provided a molecular definition of the oligometastatic state in colorectal cancer, which contributes to precise treatment decision-making for advanced patients.
Investigation of LncRNAs Expression as a Potential Biomarker in the
Diagnosis and Treatment of Human Brucellosis
Authors: Kodori Mansoor , Abavisani Mohammad , Fathizadeh Hadis , Khaledi Mansoor , Haddadi Mohammad Hossein , Aziziraftar Shahrbanoo Keshavarz , Neamati Foroogh , Sahebkar Amirhossein 
Published: September 2023

Abstract:
Long non-coding RNAs (LncRNAs) are significant contributors to bacterial infections and
host defense responses, presenting a novel class of gene regulators beyond conventional protein-coding
genes. This narrative review aimed to explore the involvement of LncRNAs as a potential biomarker in
the diagnosis and treatment of bacterial infections, with a specific focus on Brucella infections. A comprehensive
literature review was conducted to identify relevant studies examining the roles of LncRNAs
in immune responses during bacterial infections, with a specific emphasis on Brucella infections. Pub-
Med, Scopus and other major scientific databases were searched using relevant keywords. LncRNAs
crucially regulate immune responses to bacterial infections, influencing transcription factors, proinflammatory
cytokines, and immune cell behavior, with both positive and negative effects. The NF-κB
pathway is a key regulator for many LncRNAs in bacterial infections. During Brucella infections, essential
LncRNAs activate the innate immune response, increasing proinflammatory cytokine production
and immune cell differentiation. LncRNAs are associated with human brucellosis, holding promise for
screening, diagnostics, or therapeutics. Further research is needed to fully understand LncRNAs' precise
functions in Brucella infection and pathogenesis. Specific LncRNAs, like IFNG-AS1 and NLRP3, are
upregulated during brucellosis, while others, such as Gm28309, are downregulated, influencing immunosuppression
and bacterial survival. Investigating the prognostic and therapeutic potential of Brucellarelated
LncRNAs warrants ongoing investigation, including their roles in other immune cells like macrophages,
dendritic cells, and neutrophils responsible for bacterial clearance. Unraveling the intricate
relationship between LncRNAs and brucellosis may reveal novel regulatory mechanisms and LncRNAs'
roles in infection regulation, expediting diagnostics and enhancing therapeutic strategies against Brucella
infections.
Recent Patents on Long Distance Pneumatic Conveying Technology
Authors: Xia Youtao , Yang Daolong , Xing Bangsheng , Jin Fanbo , Tang Jinjing , Duan Haichao , Ma Xiaolei 
Published: September 2023

Background:
Pneumatic conveying is the use of air flow energy to transport granular materials in the direction of airflow in a closed pipeline, which involves the disadvantages of low conveying efficiency and easy deposition of particles.

Objective:
It is necessary to develop pneumatic conveying devices to reduce particle deposition, promote particles to enter the flow field again to accelerate, and achieve the effect of extending the pneumatic conveying distance.

Method:
The anti-settling device re-accelerates the particles so that the particles return to the flow field, which effectively reduces the probability of settlement blockage of material particles during transportation. The pneumatic conveying pressurized separator uses a pot-shaped housing to generate an internal rotating flow field to screen particles, and the light dust adheres to the filter, reducing the possibility of pipeline dust explosion.

Results:
The anti-settling device can quickly replace the anti-settlement block according to the parameters of the conveying pipeline, which can effectively reduce the probability of settlement blockage of material particles during transportation. The pressurized separator can use the air compressor to cooperate with the return air pipe to effectively remove the dust in the pneumatic conveying pipe and carry out secondary pressurized transportation of the materials in the pneumatic conveying pipe, which improves the safety of pneumatic conveying.

Conclusion:
The above technology improves the efficiency of pneumatic conveying and gas utilization, enhances the speed of particle conveying, reduces particle settlement and collision, extends the distance of pneumatic conveying, and ensures the safety of pneumatic conveying and the feasibility of industrial applications.
Chinese Patent Review of Integrated Management System for Agricultural
Machinery
Authors: Bao Yudong , Liu Yuying , Huang Yongqi 
Published: September 2023

Background:
With the rapid development of China's economy and the accelerating process of agricultural mechanization, agricultural machinery has become increasingly popular in agricultural production activities. At the same time, problems in agricultural machinery management have gradually been exposed, hindering the development of modern agriculture.

Objective:
This study aimed to discuss the development trend of agricultural management and modern agriculture by analyzing and discussing the related patents of agricultural machinery management systems.

Methods:
The development of agricultural machinery management was summarized, and the representative patents related to agricultural machinery management systems, agricultural machinery automatic control systems, and agricultural machinery terminals were analyzed.

Results:
By analyzing the existing patents of the agricultural machinery management system, the paper summarized their applications in agricultural management and obtained their future development trend.

Conclusion:
In agricultural machinery management, we should actively adopt complementary strategies to solve various problems and improve the management level of agricultural machinery. The continuous improvement of the agricultural machinery management system is of great significance to the automation of agricultural production and the modernization of agricultural management in China.
Unani approach to graded management of thrombosis in Covid-19 patients
Authors: Tahseen. A Zikra , Sofi Ghulamuddin , Shahid Arisha , Sofia  , Aazam Shahila 
Published: September 2023

Background and objectives:
This study aimed to explore the treatment of thrombosis caused by Covid-19 with the drugs used in Unani medicine. Unani medicine has rich literature that mentions the pathogenesis, causes, and treatment of the diseases caused by obstruction of vessels. The study explores various drugs with actions that complement the resulting thrombolytic actions and details the rational treatment plan following the Unani medicine protocol.

Methodology:
The literature regarding thrombosis was surveyed from indexed online journals. The concept of thrombosis in Unani literature was surveyed from the source texts of Unani medicine. The treatment strategy and drugs with anti-thrombotic actions were explored, and a rational graded management of thrombosis in Covid-19 patients was presented that forms the general treatment plan of Unani medicine in patients with thrombosis.

Results:
The study observed that several Unani drugs from natural sources are mentioned for de-obstruent action. De-obstruent action is a composite action that encompasses anti-inflammatory, disintegratory, blood detoxification, and other activities. There was a concordance with the concept of thrombolytic action, as mentioned in conventional medicine. When rationally used, these drugs form a graded treatment of thrombosis associated with Covid-19.

Conclusion:
There is a potentially successful treatment plan with several de-obstruent drugs in Unani medicine that may be explored to treat thrombosis associated with Covid-19.