bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement
Authors: Wu Chengzan , Kim Min-Ji , Mangal Utkarsh , Seo Ji-Young , Kim Ji-Yeong , Kim Junho , Park Ju-Young , Kwon Jae-Sung , Choi Sung-Hwan 
Published: March 2023

AbstractBiofilms induce microbial-mediated surface roughening and deterioration of cement. In this study, zwitterionic derivatives (ZD) of sulfobetaine methacrylate (SBMA) and 2-methacryloyloxyethyl phosphorylcholine, were added in concentrations of 0, 1, and 3% to three different types of commercially available resin-modified glass ionomer cement (RMGIC) (RMC-I: RelyX Luting 2, RMC-II: Nexus RMGI, and RMC-III: GC FujiCEM 2). The unmodified RMGICs served as the control group for comparison. The resistance of Streptococcus mutans to ZD-modified RMGIC was evaluated with a monoculture biofilm assay. The following physical properties of the ZD-modified RMGIC were assessed: wettability, film thickness, flexural strength, elastic modulus, shear bond strength, and failure mode. The ZD-modified RMGIC significantly inhibited biofilm formation, with at least a 30% reduction compared to the control group. The addition of ZD improved the wettability of RMGIC; however, only 3% of the SBMA group was statistically different (P < 0.05). The film thickness increased in proportion to the increasing ZD concentrations; there was no statistical difference within the RMC-I (P > 0.05). The experimental groups' flexural strength, elastic modulus, and shear bond strength showed an insignificant decrease from the control group; there was no statistical difference within the RMC-I (P > 0.05). The mode of failure differed slightly in each group, but all groups showed dominance in the adhesive and mixed failure. Thus, the addition of 1 wt.% ZD in RMGIC favorably enhanced the resistance to Streptococcus mutans without any tangible loss in flexural and shear bond strength.
The temporal cost of deploying attention limits accurate target identification in rapid serial visual presentation
Authors: Kimata Anna R. , Zheng Bryan , Watanabe Takeo , Asaad Wael F. 
Published: March 2023

AbstractLag-1 sparing is a common exception to the attentional blink, where a target presented directly after T1 can be identified and reported accurately. Prior work has proposed potential mechanisms for lag 1 sparing, including the boost and bounce model and the attentional gating model. Here, we apply a rapid serial visual presentation task to investigate the temporal limitations of lag 1 sparing by testing three distinct hypotheses. We found that endogenous engagement of attention to T2 requires between 50 and 100 ms. Critically, faster presentation rates yielded lower T2 performance, whereas decreased image duration did not impair T2 detection and report. These observations were reinforced by subsequent experiments controlling for short-term learning and capacity-dependent visual processing effects. Thus, lag-1 sparing was limited by the intrinsic dynamics of attentional boost engagement rather than by earlier perceptual bottlenecks such as insufficient exposure to images in the stimulus stream or visual processing capacity limitations. Taken together, these findings support the boost and bounce theory over earlier models that focus only on attentional gating or visual short-term memory storage, informing our understanding of how the human visual system deploys attention under challenging temporal constraints.
Adaptive mechanism in Quercus brantii Lindl. leaves under climatic differentiation: morphological and anatomical traits
Authors: Soheili Forough , Heydari Mehdi , Woodward Stephen , Naji Hamid Reza 
Published: March 2023

AbstractLeaf traits, which vary across different climatic conditions, can reveal evolutionary changes within a species made to adapt to the environment. Leaf traits play major roles in a plant functions under varying climatic conditions. To examine adaptive modes and mechanisms applied by plants in different climates, we analyzed leaf morphology and anatomical structures in Quercus brantii in the Zagros forests, Western Iran. The plants adapted to the environmental differences with increased dry matter content in a Mediterranean climate, and increasing leaf length, specific leaf area, stomata length (SL), stomata width, stomatal density (SD), stomatal pore index (SPI), trichome length, and width in a sub-humid climate; trichome density was increased in a semi-arid climate. There were strong, positive correlations between SPI with SL and SD. Correlations for other leaf traits were weakly significant. Such morphological and anatomical plasticity probably leads to lower transpiration rates, control of internal temperature and water status, and improved photosynthetic capability under stressing conditions. These findings provide new insights into the adaptive strategies of plants to environmental changes at the morphological and anatomical levels.
Successful induction of pseudopregnancy using sonic vibration in mice
Authors: Wake Yui , Endo Marina , Tsunoda Shigemi , Tawara Hirosuke , Abe Hisayuki , Nakagawa Yuki , Kaneko Takehito 
Published: March 2023

AbstractEmbryo transfer (ET) is an essential reproductive technology for the production of new animal strains and maintenance of genetic resources. We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. This study examined the application of this method for the induction of pseudopregnancy in mice. Offspring were obtained from two-cell embryos transferred into females with pseudopregnancy induced using sonic vibration in proestrus on the day before embryo transfer. Furthermore, high developmental rates of offspring were observed when pronuclear and two-cell embryos were transferred to females in estrus that were stimulated on the day of embryo transfer. Genome-edited mice were also obtained using frozen-warmed pronuclear embryos with clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system (Cas) nucleases introduced using the technique for animal knockout system by electroporation (TAKE) method, which were transferred to females with pseudopregnancy induced on the day of embryo transfer. This study demonstrated that induction of pseudopregnancy by sonic vibration was also possible in mice.
Incidence and predictors of severe postpartum hemorrhage after cesarean delivery in South Central Ethiopia: a retrospective cohort study
Authors: Zewdu Dereje , Tantu Temesgen 
Published: March 2023

AbstractSevere postpartum hemorrhage is an obstetric emergency that needs immediate intervention and is a leading cause of maternal death. Despite its significant health burden, little is known, about its magnitude and risk factors, especially after cesarean delivery in Ethiopia. This study aimed to evaluate the incidence and predictors of severe postpartum hemorrhage following cesarean section. This study was conducted on 728 women who underwent cesarean section. We retrospectively collected data from the medical records, including baseline characteristics, obstetrics, and perioperative data. Potential predictors were investigated using multivariate logistic regression analyses, adjusted odd ratios, and a 95% confidence interval to see associations. A p-value < 0.05 is considered statistically significant. The incidence of severe postpartum hemorrhage was 26 (3.6%). The independently associated factors were previous CS scar ≥ 2 (AOR 4.08: 95% CI 1.20–13.86), antepartum hemorrhage (AOR 2.89: 95% CI 1.01–8.16), severe preeclampsia (AOR 4.52: 95% CI 1.24–16.46), maternal age ≥ 35 years (AOR 2.77: 95% CI 1.02–7.52), general anesthesia (AOR 4.05: 95% CI 1.37–11.95) and classic incision (AOR 6.01: 95% CI 1.51–23.98). One in 25 women who gave birth during cesarean section experienced severe postpartum hemorrhage. Considering appropriate uterotonic agents and less invasive hemostatic interventions for high-risk mothers would help to decrease its overall rate and related morbidity.
Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation
Authors: Lan Yinghua , Zeng Wen , Wang Yu , Dong Xian , Shen Xiaoping , Gu Yangguang , Zhang Wei , Lu Hongguang 
Published: March 2023

AbstractSolar ultraviolet (UV) radiation-induced DNA damage is a major risk factor for skin cancer development. UV-induced redistribution of melanin near keratinocyte nuclei leads to the formation of a supranuclear cap, which acts as a natural sunscreen and protects DNA by absorbing and scattering UV radiation. However, the mechanism underlying the intracellular movement of melanin in nuclear capping is poorly understood. In this study, we found that OPN3 is an important photoreceptor in human epidermal keratinocytes and is critical for UVA-mediated supranuclear cap formation. OPN3 mediates supranuclear cap formation via the calcium-dependent G protein-coupled receptor signaling pathway and ultimately upregulates Dync1i1 and DCTN1 expression in human epidermal keratinocytes via activating calcium/CaMKII, CREB, and Akt signal transduction. Together, these results clarify the role of OPN3 in regulating melanin cap formation in human epidermal keratinocytes, greatly expanding our understanding of the phototransduction mechanisms involved in physiological function in skin keratinocytes.
Integrating multiple plant functional traits to predict ecosystem productivity
Authors: Yan Pu , He Nianpeng , Yu Kailiang , Xu Li , Van Meerbeek Koenraad 
Published: March 2023

AbstractQuantifying and predicting variation in gross primary productivity (GPP) is important for accurate assessment of the ecosystem carbon budget under global change. Scaling traits to community scales for predicting ecosystem functions (i.e., GPP) remain challenging, while it is promising and well appreciated with the rapid development of trait-based ecology. In this study, we aim to integrate multiple plant traits with the recently developed trait-based productivity (TBP) theory, verify it via Bayesian structural equation modeling (SEM) and complementary independent effect analysis. We further distinguish the relative importance of different traits in explaining the variation in GPP. We apply the TBP theory based on plant community traits to a multi-trait dataset containing more than 13,000 measurements of approximately 2,500 species in Chinese forest and grassland systems. Remarkably, our SEM accurately predicts variation in annual and monthly GPP across China (R2values of 0.87 and 0.73, respectively). Plant community traits play a key role. This study shows that integrating multiple plant functional traits into the TBP theory strengthens the quantification of ecosystem primary productivity variability and further advances understanding of the trait-productivity relationship. Our findings facilitate integration of the growing plant trait data into future ecological models.
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma
Authors: Srinath Abhinav , Xie Bingqing , Li Ying , Sone Je Yeong , Romanos Sharbel , Chen Chang , Sharma Anukriti , Polster Sean , Dorrestein Pieter C. , Weldon Kelly C. , DeBiasse Dorothy , Moore Thomas , Lightle Rhonda , Koskimäki Janne , Zhang Dongdong , Stadnik Agnieszka , Piedad Kristina , Hagan Matthew , Shkoukani Abdallah , Carrión-Penagos Julián , Bi Dehua , Shen Le , Shenkar Robert , Ji Yuan , Sidebottom Ashley , Pamer Eric , Gilbert Jack A. , Kahn Mark L. , D’Souza Mark , Sulakhe Dinanath , Awad Issam A. , Girard Romuald 
Published: March 2023

Abstract
Background:
Cavernous angiomas (CAs) affect 0.5% of the population, predisposing to serious neurologic sequelae from brain bleeding. A leaky gut epithelium associated with a permissive gut microbiome, was identified in patients who develop CAs, favoring lipid polysaccharide producing bacterial species. Micro-ribonucleic acids along with plasma levels of proteins reflecting angiogenesis and inflammation were also previously correlated with CA and CA with symptomatic hemorrhage.

Methods:
The plasma metabolome of CA patients and CA patients with symptomatic hemorrhage was assessed using liquid-chromatography mass spectrometry. Differential metabolites were identified using partial least squares-discriminant analysis (p < 0.05, FDR corrected). Interactions between these metabolites and the previously established CA transcriptome, microbiome, and differential proteins were queried for mechanistic relevance. Differential metabolites in CA patients with symptomatic hemorrhage were then validated in an independent, propensity matched cohort. A machine learning-implemented, Bayesian approach was used to integrate proteins, micro-RNAs and metabolites to develop a diagnostic model for CA patients with symptomatic hemorrhage.

Results:
Here we identify plasma metabolites, including cholic acid and hypoxanthine distinguishing CA patients, while arachidonic and linoleic acids distinguish those with symptomatic hemorrhage. Plasma metabolites are linked to the permissive microbiome genes, and to previously implicated disease mechanisms. The metabolites distinguishing CA with symptomatic hemorrhage are validated in an independent propensity-matched cohort, and their integration, along with levels of circulating miRNAs, enhance the performance of plasma protein biomarkers (up to 85% sensitivity and 80% specificity).

Conclusions:
Plasma metabolites reflect CAs and their hemorrhagic activity. A model of their multiomic integration is applicable to other pathologies.
A tri‐level optimization strategy incorporating wind power against coordinated cyber‐physical attacks
Authors: Li Shihao , Shi Libao 
Published: March 2023

AbstractWith the fast development of cyber‐physical power systems, coordinated cyber‐physical attacks have become one of the main threats to the security of modern power grid. Considering that it is difficult for attackers to obtain full information of the entire power grid, the coordinated cyber‐physical attack problem for partitioned power grid is studied in this paper, and a tri‐level defender‐attacker‐dispatcher optimization model with consideration of wind power uncertainty in a specific coordinated cyber‐physical attack mode is proposed. The Karush‐Kuhn‐Tucker (KKT) condition and an improved implicit enumeration algorithm are applied to obtain the solution of the complicated optimization problem effectively. In addition, two risk assessment indices pertinent to the physical lines and load measurements are proposed according to the obtained total amount of optimized load shedding and coordinated attack‐defense strategy under valid attack‐defense scenarios. Taking a partitioned IEEE 39‐bus test system as example, the risks of physical transmission lines and load measurements in different areas under attacks are elaborately studied, and the impact of wind power uncertainty on attack‐defense strategies is discussed as well. Numerical simulation results illustrate the effectiveness of the proposed optimization model and risk assessment indices, and some significant conclusions are drawn.
Optimal design method of public transit network considering transfer efficiency
Authors: Jing Dian , Yao Enjian , Chen Rongsheng , Sun Xun 
Published: March 2023

AbstractImproving the sharing rate of public transport and reducing operation costs are key factors affecting the sustainable development of the public transport system. After quantifying the impact of transfer, this study proposes a multi‐objective optimization model of bus networks considering the integral transfer efficiency and operation costs, whose optimal solution is hard to find. Since the heuristic algorithm has great global searchability, a non‐dominated sorted genetic algorithm (NSGA‐II) is adopted to solve this NP‐hard problem. Also, an adaptive mutation mode selection algorithm is proposed to enhance the solution efficiency. The optimization framework is applied to the benchmark case of the Swiss public transit network. The results show that the method significantly improves the transfer efficiency of the designed network when compared to existing studies. After calculation, it is found that enhancing the direct rate can improve transfer efficiency, but with high costs. Moreover, the proposed method can design an efficient and economic network to balance the benefits of passengers and operators in practice.
Mise en œuvre d’un programme d’activité physique adaptée chez les patients atteints de cancer : amélioration de leur qualité de vie, de leur fatigue et de leur capacité physique
Authors: Ralec Charlotte , Creff Laurent , Verdun Stéphane , Buyse Marion , Bouée Jean-Baptiste 
Published: March 2023

Introduction : Les bénéfices de l’activité physique dans la prise en charge globale en cancérologie sont maintenant reconnus. Malheureusement, l’offre de soin reste encore trop limitée et peu standardisée. Objectif : Cette étude vise à évaluer le programme d’activité physique adaptée (APA) développé au sein de notre institut en comparant les niveaux de qualité de vie, de fatigue, d’activité physique et de sédentarité ainsi que des capacités physiques à l’entrée et à la sortie du séjour de réadaptation. Méthode : Étude rétrospective sur les patients (n = 72) ayant suivi le programme d’APA entre août 2019 et avril 2021. La fatigue ressentie était déterminée par l’échelle FSS (Fatigue Severity Scale), la qualité de vie par le questionnaire MOS-SF36 (santé physique et mentale), et les capacités physiques par le TM6 (test de marche des 6 minutes). L’analyse statistique de l’évolution des paramètres étudiés a été réalisée par un test de Student apparié en cas de normalité des données ou par un test de Wilcoxon dans le cas contraire. Résultats : À la suite des 24 demi-journées du programme de réadaptation, on observait une diminution significative de la fatigue ressentie (4,3 ± 1,6 vs. 3,3 ± 1,4 ; p < 0,0001***), une amélioration de la qualité de vie évaluée par le questionnaire MOS-SF36 (score physique, mentale et santé perçue) ainsi que des capacités physiques (432 ± 115,3 vs. 490,8 ± 100,5 m ; p < 0,0001***) des patients. Conclusion : Cette expérience pilote permet de valider les bénéfices globaux de notre programme d’APA chez les patients atteints de différent type de tumeur maligne.
Adipositas und Schwangerschaft – Rolle der
körperlichen Aktivität
Authors: Ferrari Nina , Joisten Christine 
Published: March 2023

ZusammenfassungKörperlicher Aktivität vor als auch während der
Schwangerschaft hat zahlreiche positive Effekte auf Mutter und Kind. Allerdings
erreichen in Deutschland weniger als die Hälfte der Frauen im
Erwachsenenalter die Aktivitätsempfehlungen der
Weltgesundheitsorganisation, sich mindestens 150 Minuten in moderater
Ausdaueraktivität zu betätigen. In der Schwangerschaft wird die
Aktivitätszeit noch weiter reduziert. Kombiniert mit Übergewicht
oder Adipositas in der Schwangerschaft hat dies Auswirkungen auf die
mütterliche als auch auf die kindliche Gesundheit. Auf Basis der
aktuellen Literatur sollen daher beispielhaft die Effekte von Bewegung
während der Schwangerschaft auf Mutter und Kind im Kontext Adipositas
zusammengestellt sowie die aktuellen Empfehlungen zu Bewegung in dieser
Zielgruppe beschrieben werden. Darüber hinaus wird auf die potentiellen
zugrundeliegenden Mechanismen eingegangen.
Die Rolle der körperlichen Aktivität im Kontext der
bariatrischen Chirurgie
Authors: Notz Sara Johanna , Mann Oliver , Plitzko Gabriel 
Published: March 2023

ZusammenfassungDie Prävalenz der Adipositas steigt seit mehreren Jahrzehnten. Damit
einhergehend steigt die Anzahl der jährlich durchgeführten
bariatrischen Operationen sukzessive an. Die deutsche S3-Leitlinie
„Chirurgie der Adipositas und metabolischer Erkrankungen“
empfiehlt präoperativ für die meisten Patienten eine multimodale
Therapie, die auch eine Bewegungstherapie beinhaltet. Eine solche strukturell
verankerte Bewegungstherapie findet sich in den Empfehlungen zur Nachsorge
nicht. Eine alleinige Bewegungstherapie führt präoperativ in
aller Regel nicht zu signifikanten Gewichtsreduktion. Dies ist jedoch bei einem
Teil der Patienten möglich in Kombination mit einer Ernährungs-
und/oder Verhaltenstherapie. Durch eine Bewegungstherapie kann jedoch
eine über den Zeitpunkt der Operation hinausreichende, erhöhte
körperliche Aktivität erreicht werden, die sich positive auf
einen möglichen Weight Regain auswirkt. Für den Einfluss einer
Bewegungstherapie nach einem bariatrischen Eingriff auf den Gewichtsverlust ist
die Datenlage widersprüchlich. Allerdings wirkt sie sich ebenso wie die
präoperative Bewegungstherapie positiv auf einen Weight Regain aus.
Darüber hinaus scheint ein positiver Einfluss auf die Knochendichte und
somit auf das nach bariatrischen Operationen erhöhte Frakturrisiko zu
bestehen.
Die Rolle des Oxytocinsystems für die Entstehung der Depression
Authors: Sanwald Simon , Kammer Thomas , Montag Christian , Kiefer Markus 
Published: March 2023

ZUSAMMENFASSUNGOxytocin erregte aufgrund seiner Rolle für das menschliche Sozialverhalten in den letzten Jahren vermehrt Aufmerksamkeit hinsichtlich der Erforschung der Ätiologie depressiver Erkrankungen. Aktuelle Forschungsergebnisse legen die Komplexität des Oxytocinsystems und sowohl pro- als auch antisoziale Effekte des Neuropeptids offen, weshalb seine Rolle für die Salienz sozialer Reize oder allgemeiner für allostatische Prozesse diskutiert wird. Diese Arbeit fasst Befunde zu den Zusammenhängen zwischen Oxytocin und belastenden Lebensereignissen sowie zwischen Oxytocin und der Verstärkung sozialer Interaktionen zusammen. Ausgehend von diesen Verknüpfungen des Oxytocinsystems mit dem körperlichen Stresssystem und dem Belohnungssystem stellt diese Arbeit einen Versuch dar, aktuelle Theorien zur Funktion von Oxytocin auf die Depression anzuwenden, um so eine Hypothese zur Rolle des Oxytocinsystems hinsichtlich des Ursprungs der biologischen und behavioralen Korrelate dieser Störung aufzustellen.
Hoffnung für Zöliakie-Patienten: Transglutaminase-Hemmer als medikamentöse Therapieoption?
Authors: Uecker Christine , Langhorst Jost 
Published: March 2023

SummaryDie Zöliakie ist eine angeborene Autoimmunerkrankung, die unentdeckt und unbehandelt zu einer Vielzahl von Symptomen, entzündungsbedingten Schäden der Dünndarmschleimhaut und schwerwiegenden Folgeerkrankungen führen kann. Auslöser der Erkrankung ist die Aufnahme von Gluten über Nahrungsmittel. Bislang bestand die einzige zuverlässig wirksame Therapieoption in der lebenslangen strikten Einhaltung einer glutenfreien Diät. Aktuell werden Medikamente in Studien erprobt, die möglicherweise die negativen Auswirkungen der Glutenaufnahme auf die Dünndarmschleimhaut und die Symptomatik verringern bzw. verhindern.
Böser Weizen? Mehr als nur Gluten-Quelle
Authors: Ots Thomas 
Published: March 2023

SummaryIndustriell angebauter Weizen hat sich in den vergangenen Jahrzehnten stark gewandelt. Moderne Weizensorgen haben einen höheren glykämischen Index als Haushaltszucker. Der übermäßige Weizenverzehr bewirkt daher massive Blutzuckerspitzen, bei denen kurzfristige Sättigung sich mit erhöhtem Appetit abwechselt. Er begünstigt entzündliche Reaktionen sowie eine fehlgeleitete Immunmodulation. Weizen kann regelrecht süchtig machen. Ihn durch andere Getreidesorten zu ersetzen, wäre eine Möglichkeit, die Ernährungsgewohnheiten sinnvoll umzustellen.