bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-driven Learning Systems and the Commission of International Crimes
Authors: Greipl Anna Rosalie 
Published: September 2023

Abstract
Current discussions on the military use of artificial intelligence (AI), in particular concerning autonomous weapons systems, have largely focused on the challenges for the attribution of individual criminal responsibility for war crimes whenever such systems do not perform as initially intended by human operators. Yet, recent observations evidence the pressing need to shift the discussion on the responsibility gap further to include challenges raised by the intentional use of AI systems for the commission of war crimes and other international crimes. Additionally, the increasing development and use of AI systems, based on data-driven learning (DDL) methods, demands particular attention due to the difficulty these systems’ lack of predictability and explainability poses in terms of anticipation of their effects. Against this background, this article complements the present discussion on the responsibility gap by discussing some concerns that the intentional use of DDL systems for the commission of international crimes raises regarding the required mental element and thus, the ascription of individual criminal responsibility. Ultimately, this article proposes preliminary avenues to address these concerns.
A probabilistic temporal epistemic logic: Decidability
Authors: Ognjanović Zoran , Stepić Angelina Ilić , Perović Aleksandar 
Published: September 2023

Abstract
We study a propositional probabilistic temporal epistemic logic $\textbf {PTEL}$ with both future and past temporal operators, with non-rigid set of agents and the operators for agents’ knowledge and for common knowledge and with probabilities defined on the sets of runs and on the sets of possible worlds. A semantics is given by a class ${\scriptsize{\rm Mod}}$ of Kripke-like models with possible worlds. We prove decidability of $\textbf {PTEL}$ by showing that checking satisfiability of a formula in ${\scriptsize{\rm Mod}}$ is equivalent to checking its satisfiability in a finite set of finitely representable structures. The same procedure can be applied to the class of all synchronous ${\scriptsize{\rm Mod}}$-models. We give an upper complexity bound for the satisfiability problem for ${\scriptsize{\rm Mod}}$.
Looking ahead to the sky with the Square Kilometre Array: simulating flux densities and resolved radio morphologies of 0 &lt; z &lt; 2.5 star-forming galaxies
Authors: Coogan Rosemary T , Sargent Mark T , Cibinel Anna , Prandoni Isabella , Bonaldi Anna , Daddi Emanuele , Franco Maximilien 
Published: September 2023

ABSTRACT
SKA-MID surveys will be the first in the radio domain to achieve clearly sub-arcsecond resolution at high sensitivity over large areas, opening new science applications for galaxy evolution. To investigate the potential of these surveys, we create simulated SKA-MID images of a ∼0.04 deg2 region of GOODS-North, constructed using multi-band HST imaging of 1723 real galaxies containing significant substructure at 0 &lt; z &lt; 2.5. We create images at the proposed depths of the band 2 wide, deep, and ultradeep reference surveys (RMS = 1.0, 0.2, and 0.05 μJy over 1000, 10–30, and 1 deg2, respectively), using the telescope response of SKA-MID at 0.6 arcsec resolution. We quantify the star formation rate – stellar mass space the surveys will probe, and asses to which stellar masses the surveys will be complete. We measure galaxy flux density, half-light radius (R50), concentration, Gini (distribution of flux), second-order moment of the brightest pixels (M20), and asymmetry before and after simulation with the SKA response, to perform input-output tests as a function of depth, separating the effects of convolution and noise. We find that the recovery of Gini and asymmetry is more dependent on survey depth than for R50, concentration and M20. We also assess the relative ranking of parameters before and after observation with SKA-MID. R50 best retains its ranking, while asymmetries are poorly recovered. We confirm that the wide tier will be suited to the study of highly star-forming galaxies across different environments, whilst the ultradeep tier will enable detailed morphological analysis to lower SFRs.
Imaging rotating and orbiting exoplanets with the solar gravitational lens
Authors: Toth Viktor T , Turyshev Slava G 
Published: September 2023

ABSTRACT
We utilize the well-established properties of the solar gravitational lens (SGL) to consider more realistic observational scenarios. Actual exoplanets, which may be the target of an SGL observational campaign, are not stationary. Their appearance also changes in a variety of ways, including changes due to their diurnal rotation and varying illumination due to their orbital motion around their host star. The nature of the SGL is such that imaging with one telescope is accomplished with a cadence of one pixel at a time, with substantial per-pixel integration times. Therefore, capturing a single snapshot of the target planet with a realistically sized telescope is not possible. Instead, the planetary surface must be reconstructed by inverting the combined effect of the SGL’s point-spread function and temporal changes induced by the planetary dynamics. Using the Earth as a stand-in, we demonstrate practical feasibility of this approach, by simulating a dynamical system and then recovering topographic images of acceptable quality. The dynamics-induced temporal variability of the exoplanet represents an added challenge, but even in the presence of such dynamics, use of the SGL for exoplanet imaging remains feasible.
CO, H2O, and CH4 in the dusty atmosphere of a ≲5 Myr-old exoplanet
Authors: Gaidos Eric , Hirano Teruyuki 
Published: September 2023

ABSTRACT
Very young massive planets are sufficiently luminous by their internal heat of formation to permit detailed studies, including spectroscopy of their atmospheres with large telescopes at sufficient resolution (λ/Δλ ≳ 1000) to identify major constituents to inform models of planet formation and early evolution. We obtained 1–2.4 μm (YJHK) spectra of the planetary-mass ‘b’ companion of 2MASS J04372171+2651014, a 1–3 Myr-old M dwarf member of the Taurus star-forming region, and one of the youngest such objects discovered to date. These indicate the presence of CO and possibly H2O and CH4 in the atmosphere, all suggesting a Teff of around 1200 K, characteristic of a L-T transition spectral type and consistent with previous estimates based on its luminosity and age. The absence or attenuation of spectral features at shorter wavelengths suggests the presence of micron-size dust, consistent with the object’s red colour. The spectrum of 2M0437b resembles those of the HR 8799 planets, especially the innermost ‘b’ planet, with the exception of a pronounced flux deficit in the H-band of uncertain origin.
Larger tumor volume is associated with visual acuity loss and axonal degeneration in children with optic pathway gliomas secondary to neurofibromatosis type 1
Authors: Avery Robert A , Mansoor Awais , Liu Grant T , Trimboli−Heidler Carmelina , Ying Gui−Shuang , Centrella Cameron R , Eltoukhy Nadeen , Packer Roger J , Fisher Michael J , Linguraru Marius George 
Published: September 2023

Abstract

Background
We investigated whether volumetric magnetic resonance imaging (MRI) measures of the anterior visual pathway (AVP) in optic pathway gliomas secondary to Neurofibromatosis type 1 (NF1−OPG) are associated with visual acuity (VA) loss and axonal loss, as measured using optical coherence tomography (OCT).

Methods
Children with NF1−OPGs enrolled in a prospective study of VA and OCT measures of the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were eligible if they had undergone 3-Tesla MRI that included a T1-weighted volumetric sequence. The linear dimension and volume of the optic nerves, chiasm, and optic tracts were measured using our semi-automated algorithm. The combined volume of these components comprising the proximal AVP was used as a surrogate of total tumor burden. Regression models for VA and cpRNFL thickness were reported on a per-eye basis.

Results
Fifty−two study eyes (26 children, mean 7.1 years) met inclusion criteria, of which 40% (N = 21 eyes) had abnormal VA. In regression analysis, only total AVP volume demonstrated a significant relationship to axonal loss, such that for every 1 mL increase in AVP volume, cpRNFL declined by 5.4 microns (P = .01). Total AVP volume &gt; 1.75 mL predicted both axonal loss and abnormal VA (positive predictive value of 83.3% and 70.8%, respectively; negative predictive value of 80.0% and 88.0%, respectively).

Conclusions
Volumetric measures of NF1-OPGs identified children with VA loss and axonal degeneration. Total tumor burden, as measured by AVP volume, had the strongest relationship with axonal injury. NF1-OPG volumetric measures may be helpful in making treatment decisions.
The sex-dependent impact of PER2 polymorphism on sleep and activity in a novel mouse model of cranial-irradiation-induced hypersomnolence
Authors: Adegbesan Kendra A , Tomassoni Ardori Francesco , Yanpallewar Sudhirkumar , Bradley Sean P , Chudasama Yogita , Vera Elizabeth , Briceno Nicole , King Amanda L , Tessarollo Lino , Gilbert Mark R , Guedes Vivian A , Smart DeeDee K , Armstrong Terri S , Shuboni-Mulligan Dorela D 
Published: September 2023

AbstractBackgroundHypersomnolence is a common and disruptive side effect of cranial radiotherapy and is associated with fatigue and disturbances in mood and cognition in primary brain tumor (PBT) patients. The biological underpinnings of this effect are not understood. Our laboratory has previously found that the presence of a single nucleotide polymorphism (rs934945, G-E mutation) in the PERIOD2 (PER2) clock gene was associated with a decreased likelihood of fatigue in PBT patients. Here, we aim to understand the effects of PER2 polymorphism on radiation susceptibility within a murine model of cranial-irradiation-induced hypersomnolence (C-RIH).MethodsMale and female transgenic mice were generated using CRISPR-Cas9, replacing the endogenous mouse PER2:CRY1 binding domain with its human isoform with (hE1244 KI) or without the SNP rs934945 (hG1244 KI). Activity and sleep were monitored continuously 10 days before and after cranial irradiation (whole brain, 15Gy, single fraction). Behavioral assessments measuring anxiety, depression, and working memory were used to assess mood and cognitive changes 2 months postradiation.ResultsDuring their active phase, hE1244 knock-ins (KIs) had less radiation-induced suppression of activity relative to hG1244 KIs and female hE1244 KIs saw a reduction of hypersomnolence over 10 days. hE1244 KIs displayed less anxiety behavior and were more ambulatory within all behavioral tests.ConclusionsThe PER2 rs934945 polymorphism had long-lasting behavioral effects associated with radiation toxicity, particularly in sleep in females and the activity of all animals. Our findings shed light on biological mechanisms underlying C-RIH.
Left Ventricular Ejection Fraction in Patients With Ovarian Cancer Treated With Avelumab, Pegylated Liposomal Doxorubicin, or Both
Authors: Bonaca Marc P , Moslehi Javid J , Ledermann Jonathan A , Michelon Elisabete , Wei Caimiao , Moran Michael , Monk Bradley J , Pujade-Lauraine Eric 
Published: September 2023

Abstract

In the phase III JAVELIN Ovarian 200 trial, 566 patients with platinum-resistant/refractory ovarian cancer were randomized 1:1:1 to receive avelumab alone, avelumab plus pegylated liposomal doxorubicin (PLD), or PLD alone. Cardiac monitoring was included for all patients. We report left ventricular ejection fraction (LVEF) data from the trial. Grade ≥3 cardiac adverse events (AEs) occurred in 4 (2.1%), 1 (0.5%), and 0 patients in the avelumab, combination, and PLD arms, respectively. LVEF decreases of ≥10% to below institutional lower limit of normal at any time during treatment were observed in 1 (0.8%), 3 (1.9%), and 2 (1.5%) patients, respectively; 4 had subsequent assessments, and these showed transient decreases. No patient had a cardiovascular AE related to LVEF decrease. This analysis is, to our knowledge, the first analysis of LVEF in patients receiving immune checkpoint inhibitors.

ClinicalTrials.gov Identifier
NCT02580058.
Predicting Response to Antibody Drug Conjugates: A Focus on Antigens’ Targetability
Authors: Ascione Liliana , Crimini Edoardo , Trapani Dario , Marra Antonio , Criscitiello Carmen , Curigliano Giuseppe 
Published: September 2023

Abstract
Antibody-drug conjugates (ADCs) represent a cornerstone in the treatment of many cancers nowadays. ADCs fulfill their function by binding a target on tumor cell membrane to deliver a cytotoxic payload; in addition, those moieties capable of crossing cancer cell membranes can achieve near-by cells that do not express the target antigen, exerting the so-called “bystander” cytotoxic effect. The presence of a specific target antigen expressed on cancer cells has been for long considered crucial for ADCs and commonly required for the inclusion of patients in clinical trials with ADCs. To date, only ado-trastuzumab-emtansine, fam-trastuzumab deruxtecan-nxki, and mirvetuximab soravtansine-gynx are approved according to the expression of a target antigen in solid tumors, while the clinical use of other ADCs (eg, sacituzumab govitecan) is not conditioned by the presence of a specific biomarker. Given the ever-growing number of approved ADCs and those under investigation, it is essential to find new biomarkers to guide their use, especially in those settings for which different ADCs are approved to establish the best therapeutic sequence based on robust biomarkers. Hence, this work addresses the role of target antigens in predicting response to ADCs, focusing on examples of antigens’ targetability according to their expression on cancer cells’ surface or to the presence of specific target aberrations (eg, mutation or over-expression). New methods for the assessment and quantification of targets’ expression, like molecular imaging and in vitro assays, might be key tools to improve biomarker analysis and eventually deliver better outcomes by refined patient selection.
Cliff or bridge: breaking up with the paediatric healthcare system
Authors: Baumbusch Jennifer 
Published: September 2023

Abstract
Transition from paediatric to adult healthcare is a normal part of the care trajectory, yet the process often leaves much to be desired. In this commentary, I share my family’s journey of this care transition, particularly the handover aspect, by providing examples of different ways that relationships were ended by paediatric healthcare professionals. The ending of these relationships often felt like ‘breaking up’. I also share an example of a supported handover, which bridged the transition from paediatric to adult care. To improve transitions, we need genuine acknowledgement of the paediatric medical trauma stress (PMTS) experienced by families such as mine following years of interactions in the healthcare system. Along with following transition checklists, patients and families need authentic and meaningful closure to longitudinal relationships and trauma-informed care practices as we move forward into the adult care system.
Childhood Schizotypy and Adolescent Mental Disorder
Authors: O’Hare Kirstie , Watkeys Oliver , Dean Kimberlie , Laurens Kristin R , Tzoumakis Stacy , Harris Felicity , Carr Vaughan J , Green Melissa J 
Published: September 2023

Abstract

Background and Hypothesis
Schizotypy provides a framework for understanding the developmental nature of psychotic disorders and a means of identifying “at-risk” individuals early in the lifespan. However, there is a lack of prospective longitudinal research examining the relationship between schizotypy in childhood and later psychotic and other mental disorders. We hypothesized that distinct profiles of schizotypy in childhood would be differentially associated with psychotic and other mental disorders emerging later in adolescence.

Study Design
In a large population cohort of Australian young people (n = 26 837), we prospectively examined the relationship between person-centered profiles of schizotypy identified in middle childhood (age ~11 years) and adolescent diagnoses (age ~13–18 years) across 7 types of mental disorders using multinomial logistic regression.

Results
Membership in any of 3 childhood schizotypy profiles (true schizotypy, affective schizotypy, or introverted schizotypy) was associated with an increased likelihood of being diagnosed with any type of mental disorder in adolescence; effects were strongest for the true schizotypy group (aOR = 3.07, 95% CI = 2.64, 3.57), followed by the introverted (aOR = 1.94, 95% CI = 1.75, 2.15) and affective (aOR = 1.29, 95% CI = 1.13, 1.47) schizotypy groups. Six of the 7 types of mental disorders measured (including psychotic disorders) were associated with at least 1 schizotypy group.

Conclusions
Schizotypy in middle childhood is an important correlate of mental disorders in adolescence; however, it does not appear to be specifically associated with psychotic disorders in this age group.
Pleasure despite pain: Associations between experiences of vulvar pleasure, vulvar pain, and sexual function in patients with chronic vulvar pain conditions
Authors: Mautz Theodora T , Mulroy Maeve E , Krapf Jill M , Goldstein Andrew T , Pukall Caroline F 
Published: September 2023

Abstract

Background
Chronic pain can occur in the vulva, one of the primary pleasure centers of the body; however, the associations between pleasurable vulvar experiences and chronic vulvar pain have not yet been explored.

Aim
The aim of this study was to investigate associations between vulvar pleasure and pain experiences in patients with chronic vulvar pain.

Methods
This was a prospective cross-sectional study of 547 patients (aged ≥17 years) presenting over 10 months to 2 urban outpatient gynecology clinics specializing in vulvar pain. Prior to the initial evaluation, patients completed online validated questionnaires of pain-related anxiety, pain catastrophizing, and sexual functioning, as well as a researcher-developed questionnaire evaluating vulvar pleasure. Patients were divided into groups based on their pleasure and pain experiences. Between-group analyses consisting of t-tests, analyses of variance, and multivariate analyses of variance were conducted.

Outcomes
Outcomes consisted of total and subscale scores on the Pain Anxiety Symptoms Scale-20, Pain Catastrophizing Scale, Female Sexual Function Index, and a researcher-developed vulvar pleasure questionnaire.

Results
More than 70% of patients with chronic vulvar pain had experienced vulvar pleasure since the onset of their vulvar pain, with the clitoris as the most common source of pleasure. Average vulvar pleasure intensity was rated 7 (0, no pleasure; 10, extremely pleasurable). Masturbation ranked higher in pleasurable activities than vulvar stimulation by a partner or penetrative intercourse and was the most likely activity to lead to orgasm. When compared with patients who had not experienced vulvar pleasure since the onset of their vulvar pain, patients experiencing both pain and pleasure scored lower on the Pain Anxiety Symptoms Scale-20 total (P = .026) and fear subscale (P = .016), lower on the Pain Catastrophizing Scale total (P = .002) and all subscales (P = .008-.018), and higher on the Female Sexual Function Index total and all subscales (all P ≤ .001).

Clinical Implications
Incorporating strategies for cultivating vulvar pleasure in patients with chronic vulvar pain may be useful in comprehensive management approaches.

Strengths and Limitations
Strengths of this study include the novel examination of vulvar pleasure in a population with chronic vulvar pain and a large sample size. Limitations include the lack of a nonclinical comparator group and reliance on patient self-report.

Conclusion
Results suggest that greater vulvar pleasure is associated with lower pain-related anxiety, lower pain catastrophizing, and higher sexual functioning in patients with chronic vulvar pain conditions.
Abstract 2 Results of an Open Label Expanded Access Study of Omidubicel-onlv for Allogeneic Transplantation (allo-HCT) in Patients with Hematologic Malignancies
Authors: Horwitz Mitchell , Schiller Gary , Tsai Stephanie , Rezvani Andrew , Maziarz Richard , Goshen Uri , Levy Stuart , Schwarzbach Aurelie , Mazor Roei , Stiff Patrick 
Published: September 2023

Abstract

Introduction
Omidubicel, a nicotinamide expanded allogeneic hematopoietic progenitor cell therapy derived from umbilical cord blood (UCB) was recently FDA approved for use as a sole donor source in allo-HCT based on phase III study results showing improved hematopoietic recovery and decreased infection rate compared to standard UCB.

Objectives
Open label, single arm expanded access program (EAP) evaluating clinical outcomes for patients with hematologic malignancies following omidubicel allo-HCT.

Methods
Eligible patients (&gt;12 years) received myeloablative conditioning with supportive care per institutional guidelines. Patients were followed for engraftment, infections, graft versus host disease (GVHD), and two year post-transplantation outcomes.

Results
Between July 2020 and April 2023, 36 patients were enrolled at 5 US centers, and 29 (18 male, 11 female) were transplanted; median age was 38 years (range: 20-73); 55.2% white, 17.2% Black, 20.7% Asian, 10.3% other. Diagnoses included AML (37.9%), ALL (27.6%), MDS (20.7%) and other (13.8%). Median transplanted CD34+ cell dose was 5.6x106 cells/kg and HLA match was 4/6 in 51.7%, 5/6 in 44.8%, and 6/6 in 3.5%.
Median follow-up was 6.25 months (range 0.33-27.7). At 100 and 365 days post-transplant, PFS rates were 95.5% and 82.9%, and OS rates were 96.3% and 84.4%, respectively. No infusion reactions were reported. Median neutrophil (&gt;500/µl x3 days) and platelets (&gt;20,000/µl x7 days) engraftment times were 12 and 33 days, respectively. Primary graft failure occurred in 2 (6.9%) patients, both alive &gt;100 days after second transplant. Incidence of first grade 2 or 3 bacterial, viral, or invasive fungal infections through 100 days post-transplantation were 13.8%, 24.1% and 0%, respectively.
Acute GVHD was reported in 13 (44.8%) patients (grade II: 34.5%, grade III: 10.3%) and mild chronic GVHD in 1 (3.5%). There were 4 deaths (13.8%): 2 due to relapse @275 and 381 days, 1 due to infection (day 135) and 1 due to pulmonary failure on day 10. Post-transplant lymphoproliferative disease was reported in one.

Discussio
In this real-world EAP setting, allo-HCT with omidubicel was well tolerated, and observed engraftment and infections consistent with published Phase 3 data. These data further support the role of omidubicel particularly for patients from diverse racial backgrounds.