bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Multimodal Integrative Interventions on Pain-Related Outcomes among Critically Ill Patients
Authors: Taha Amal S. , Mohamed Safaa H. , Mahmoud Doaa M. 
Published: February 2023

Context: Pain, a persistent problem in critically ill patients, adversely affects outcomes. Despite recommendations, no evidence-based non-pharmacological approaches for pain treatment in critically ill patients have been found.
Aim: To evaluate the effect of multimodal integrative interventions on pain-related outcomes among critically ill patients.
Methods: A quasi-experimental design (pre / post-test) was utilized to fulfill the aim of this study. A convenience sample of sixty adult critically ill patients was recruited from the intensive care unit at Benha University Hospital, affiliated to Benha University at Qualyubia Governorate, Egypt. Three tools were used to conduct this study as follows: Critically ill patients' assessment record; The Critical-Care Pain Observation Tool (CCPOT); The Groningen Sleep Quality Scale.
Results: The results show decreased frequency of pain occurs in the post-intervention periods (75%) immediately post to 50% after 48 hours of intervention compared with pre-intervention (100%). The results show highly statistically significant differences at p ≤0.001 between pre and post of intervention periods regarding the intensity of the pain mean score among studied patients. It also shows statistically significant differences with p-value ≤0.05 regarding all items of sleep quality immediately after and after 48 hours of intervention compared to pre-intervention, except those related to having a deep sleep last night and feeling like a slept poorly last night with a p-value ≥0.05. There was a highly positive statistically significant correlation at p-value ≤ 0.001 between pain intensity and other secondary outcomes, including quality of sleep, blood pressure, heart rate, and respiratory rate.
Conclusion: Multimodal integrative interventions effectively decrease pain and improve pain-related outcomes among critically ill patients. Appropriate pain assessment must be partnered with an adequate, multimodal, evidence-based management strategy that incorporates pharmacologic and non-pharmacologic pain control modalities.
An Occupational Health Program for Waste Collection Workers
Authors: Awad Howida E. , Farahat Nadia H. , Mohamed Hala M. 
Published: February 2023

Context: Waste collection is necessary worldwide for inhabitants' health and living conditions. Waste collection workers are at risk of disease from exposure to various work hazards and fatal and nonfatal occupational accidents.
Aim: Evaluate the effect of an occupational health program on waste collection workers' knowledge and practices.
Methods: A quasi-experimental (pre and post-test) design was used. All five zones of the Suez Governorate were recruited for the data collected through the General Authority for Cleanliness and Beauty (GACB). A purposive sample of 95 formal waste collection workers conveniently participated in this study. Two tools were used for the assessment of knowledge and practices. An interview questionnaire was used to collect data regarding the waste collection workers’ demographic data, work characteristics, medical history, and habits. It also assesses the knowledge of the waste collection workers regarding occupational health safety. A reported practice checklist was used to assess the waste collection workers’ practices regarding safe waste collection practices.
Results: The present study reveals that all the study sample was males, with a mean age of 38.76±5.13, 51.6% can read and write, had a mean year in occupation of 10.59±4.84, and had no training. 92.6% were previously injured during their work. The comparison of waste collection workers’ total knowledge reveals statistically significant differences between pre-and post-program at p<0.05, while total practices of the waste collection workers are unsafe in pre- and had improved post-program with statistically significant differences between pre-and post-program implementation regarding all safety practices.
Conclusion: Based on the present study findings, waste collection workers had better knowledge and safe practices after program implementation than their pre-program levels. The ongoing occupational health program is highly needed by the waste collection workers related to hazards of waste collection and preventive measures. Scheduled medical surveillance and availability of supervision by GACB to provide protection devices and equipment are strongly recommended.
PELAKSANAAN TANGGUNG JAWAB PERUSAHAAN BONGKAR MUAT DALAM PROSES BONGKAR MUAT BARANG
Authors: Jabalnur Jabalnur , Intan Nur , Zakyudin Al Abrar Muh 
Published: February 2023

Tujuan ini bertujuan untuk mengetahui (1) apakah bentuk tanggungjawab perusahaan bongkar muat apabila terjadi kerusakan barang dalam pelaksanaan bongkar muat serta (2) upaya hokum apakah yang di lakukan konsumen terhadap perusahaan bongkar muat. Penelitian ini di lakukan dengan menggunakan Metode penelitian Normatif dan Empiris. Pendekatan Empiris yaitu penelitian hukum yang mempergunakan data sekunder. Sedangkan penelitian Normatif adalah penelitian yang di lakukan dengan kajian pustaka serta refrensi lain dari berbagai situs. Subjek penelitian adalah pihak-pihak yang terkait dengan pelaksanaan tanggung jawab Perushaan bongkar muat terhadap kerugian yang timbul atas barang dalam proses bongkar muat. Data primer dan data sekunder diperoleh melalui studi pustaka dan observasi langsung dengan alat pengumpul data studi wawancara. Hasil penelitian menunjukkan bahwa dalam pelaksanaan bongkar muat barang pada Perusahaan bongkar muat dalam melaksanakan bongkar muat barang dipelabuhan. Perushaaan bongkar muat bertanggungjawab atas segala sesuatu yang terjadi oleh pengguna jasa perusaahan bongkar muat terkecuali ada perjanjian sebelumnya. Perusahaan bongkar muat dalam melaksanakan tugas dan fungsinya sesuai dengan anggaran dasar perusahaan bongkar muat dan upaya hokum di lakukan ketika terjadi kerusakan barang dengan cara negosiasi kedua bela npihak dan meguntungkan satu sama lain. Hal ini yang di lakukan oleh konsumen terhadap perusahaan bongkar muat
A Cross-sectional study on Knowledge, Attitude and Practice towards Female Condom use among Adolescents and Young Adults attending Naguru Teenage information and Health Centre, Kampala District.
Authors:   , Nakirijja Sharon , Nabushawo Okecho Florence 
Published: February 2023

Objective: This study aimed to assess the knowledge, attitude, and practice of female condom use among adolescents and young adults attending Naguru Teenage Information and Health Centre, Kampala district in July 2021. Methodology: A cross-sectional study was used among 384 participants. The inclusion criteria considered adolescents and young adults. Results: Analyses revealed that less than a quarter of the participants (24.7%) had ever used a female condom. Indeed, this is confirmed by the interval of use which was reported to be common “sometimes” (83.1%). Regarding knowledge of condom use among the participants surveyed; more-than half (86.2%) had ever heard of female condoms. The commonest sources of information on female condom use included parents, health facilities, and media outlets. Most participants didn’t know how to fit a female condom (64.1%) and most reported that they didn’t know how to introduce a female condom by self. Most participants (51.3%) strongly disagreed that female condom use reduces sexual pleasure. Conclusion: Estimates from reports from this survey reflect that few adolescents and young adults use female condoms. More efforts are required to promote the use of female condoms among these age groups. The provision of information and open discussion about female contraception could influence their knowledge, attitude, and female condom use. Recommendations: For the service providers, adolescents, and young adults: the provision of information and open discussion about female contraception could influence their knowledge, attitude, and female condom use. Culture, religion, and approval of the female condom approach are still strong in the national context; this is reflected in the reports from the surveyed participants in this study thus interfering with the decision to use female condoms. The inclusion of partners and religious leaders in reproductive strategies hence constitutes a positive turning point in promoting female condom knowledge, attitude, and practice.
Assessment of serum zinc and its correlation with atherogenic index of plasma in type 2 diabetes
Authors: Chandru Swetha , Biswas Monalisa , Honnavalli Pranav K. , Choudhury Ipsita 
Published: February 2023

Introduction and Aim: Diabetes, a global health concern, is often compounded by nutritional perturbations. Micronutrients seem to play a regulatory role in the pathogenesis and progression of type 2 diabetes and recent evidence implicates a pivotal role of zinc in diabetes. The study aims to evaluate serum levels of zinc in diabetic patients and assess the correlation of zinc with lipid profile and ASCVD perturbations.
Methodology: The present study was carried out in the Department of Biochemistry and Medicine of a tertiary care centre. 30 voluntarily consenting patients diagnosed with diabetes were recruited as cases while 30 non diabetic participants were recruited as controls. Blood samples from the participants were analysed for blood glucose, lipid profile, and serum zinc in Clinical Biochemistry Lab. Mann Whitney U test and Spearman’s rank correlation were performed to obtain statistical evidence.
Results: Serum Zinc levels were significantly decreased in diabetics when compared to healthy controls. However, no statistical significance was observed among the two groups in lipid parameters, derived lipid ratios, and AIP. Serum zinc did not show a significant correlation with lipid profile, derived lipid risk assessment ratios, and AIP.

Conclusion: Serum zinc levels are significantly lower in diabetics when compared to healthy subjects thus indicating the mechanistic role of zinc in the pathophysiology of T2DM. However, large cohort studies are required to clearly explain the extent of zinc deficiency and the therapeutic role/effect of zinc correction in patients with T2DM.
The utility of biomarkers in the prediction of preterm birth: A nested case control study of the ASPIRIN trial
Authors: R. Araganji Ramesh , S. Somannavar Manjunath , Vernekar Sunil S. , Kavi Avinash , Hoffman Matthew K. , Goudar Shivaprasad S. 
Published: February 2023

Introduction and Aim: Adverse pregnancy outcomes (APO’s-preterm birth, foetal growth restriction and hypertensive disorders of pregnancy (HDP)) are the primary drivers of perinatal mortality. C-Reactive Protein, Anti-Mullerian Hormone (AMH) and Alpha-FetoProtein (AFP) have shown promise in predicting these APO’s. Aim of this present work is to validate the predictive ability of these biomarkers to identify women at risk for preterm birth.

Materials and Methods: A nested observational case-control study was performed drawing nulliparous pregnant women between 10 to 13 weeks and 17 to 21 weeks of gestation in nulliparous women randomized to aspirin or placebo as part of the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated Risk Reduction in Nulliparas) trial.

Results: A total of 126 women with these APO’s and 143 controls were selected for analyte analysis. None of the chosen analytes were found to predict preterm birth before 37 weeks or HDP. AFP obtained between 10 to 13 weeks, was able to moderately discriminate against women who had a preterm birth prior to 34 weeks (C-statistic 0.65- 95% CI 0.55 to 0.78). No other analytes were found to be predictive of preterm birth prior to 34 weeks.

Conclusion: Elevated Alpha-FetoProtein early in pregnancy is associated with early preterm birth (PTB) and may be a marker of Aspirin efficacy.
Development and validation of an RP-HPLC method for determination of Metformin and Evogliptin in bulk and pharmaceutical dosage forms
Authors: Kaveripakam Sai Sruthi , Kuruva Poojitha Sai , Adikay Sreedevi 
Published: February 2023

Introduction and Aim: In this study, a new sensitive and rapid HPLC method was developed to determine Metformin hydrochloride and Evogliptin tartrate in pharmaceutical dosage forms.

Materials and Methods: Chromatographic separation of Metformin and Evogliptin was achieved on Waters Alliance-e2695 by using Waters XTerra RP-18 150X4.6 mm, 3.5µ column, and the mobile phase containing Acetonitrile: KH2PO4: Methanol in the ratio of 50:40:10% v/v.

Results: The flow rate was 1.0 ml/min; detection was carried out by absorption at 228 nm using a photodiode array detector at ambient temperature.

Conclusion: This method was a simple, economical, suitable, precise, accurate and robust method for quantitative analysis of Metformin and Evogliptin study of its stability.
Polymorphism in SNP rs972283 of the KLF14 gene and genetic disposition to peptic ulcer
Authors: Bresam Sabah , M. Kh Al-Jumaily Rakad , F. Karim Gulbahar , Al-Rubaii Bahaa Abdullah Laftaah 
Published: February 2023

Introduction and Aim: Kruppel Like Factor 14 (KLF14) gene plays an important role in metabolic illnesses and is also involved in the regulation of many other biological processes. This study's objective was to determine whether or not the KLF14 single-nucleotide-polymorphism (SNP) known as rs972283 was linked to an increased risk of peptic ulcer disease in the population that was being investigated.

Materials and Methods: Participants in this study included 71 people who had been diagnosed with peptic ulcers and 50 people who were considered to be healthy controls. In order to genotype the KLF14 SNP rs972283, an amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was carried out, and the PCR results were then sequenced.

Results: Genotypes (GG, AG, and AA) were significantly different in people who had peptic ulcers compared to those who were in the control group (chi-square=7.703, 5.317 and 4.294) respectively. AG and AA genotypes for KLF14 gene were correlated with a high risk of peptic ulcer (P 0.05) (Odds Ratio (O.R.) =6.343 and 2.441) respectively. Patients with peptic ulcer had a significantly greater incidence of the allele A gene (30.3%), whereas healthy people had a much higher incidence of the G allele (86%). Patients who carried the AG genotype and had a chronic H. pylori infection were found to have a highly significant correlation with one another (P 0.01, O.R. =1.218). Similarly, there was a higher frequency of the G allele (84.6%), in people who had peptic ulcers, but there was a higher frequency of the A allele (39%), in cases of chronic infection.

Conclusion: According to the findings of this research, a variant in the KLF14 gene called rs972283 is linked to an increased risk of peptic ulcer illness.
Effects of physicochemical changes (temperature, pH, and culture media) on strong biofilm formation of Acinetobacter baumannii isolated from patients with respiratory infection in Iraq
Authors: Sabah Mutashar Shaymaa , Al-Mudallal Nada H. A. L. , Jawad Ridha Dunya 
Published: February 2023

Introduction and Aim: The ability of Acinetobacter baumannii to form biofilms on biotic and abiotic surfaces is regulated by several pathogens’ virulence factors, and this is thought to be at the root of the bacteria's resistance to antibiotics. We hope to learn how temperature, pH, and iron concentrations influence the development of biofilms in A. baumannii isolated from COVID-19 and non-COVID-19 individuals, and which genes are relevant for biofilm formation and antibiotic resistance.

Materials and Methods: Eight strong adherent isolates of A. baumannii from respiratory tract infection Iraqi patients (4 from COVID-19 and the other from non-COVID-19 just respiratory patients) had been used in this study which conducted from 10/1/2021 to 10/2/2022. The antibiotic sensitivity of all isolates was determined using the VITEK-2 system. The biofilm associated genes OXA-51, bap, Chaperone Usher (CsuE) and Integron-1, was detected using PCR. Isolates of A. baumainni were put through a battery of tests to determine whether they possessed the capacity to produce robust biofilms under a wide range of both physical (temperature, pH) and chemical circumstances.

Results: A. baumannii showed that all isolates were multidrug resistant and positive for the biofilm genes studied. Effect on temperature on biofilm formation showed at 44ºC biofilm formation was significantly lower than that at 37ºC (mean differences of 0.178000 (t= 8.355, df:3, P=0.004) and 0.204000 (t=26.521, df:3, P=0.000) respectively). The adhesion factor value in the COVID-19 positive and negative groups decreased significantly because of the pH change. Iron concentration of 60 µM significantly lowered biofilm formation among COVID-19 group and non-COVID-19 group.

Conclusion: A. baumanni are multidrug resistance isolates with a capacity to form biofilms. The ability to form biofilms by A. baumannii is strongly influenced by physical and chemical factors.
VALIDASI PEMAHAMAN ISHARI TERHADAP HADIS
Authors: Nikmah Shofiatun 
Published: February 2023

Dalam sejarah perkembangan kajian hadis, interaksi antara hadis dan kaum sufi mendapatkan perhatian khusus. Kaum sufi melihat teks sebagai wahyu al-matlu yang teksnya memiliki dua sisi pembacaan. Hadis memiliki sisi zahir dan bathin yang isharah maknanya tidak dapat ditangkap oleh menusia secara umum. Penelitian ini bertujuan untuk mengungkap bagaimana pendekatan ishari digunakan oleh kaum sufi dalam memahami hadis. Tulisan ini juga akan mengklarifikasi keabsahan pemahaman ishari dalam kajian hadis. Bagaimana kaidah yang telah ditetapkan para ulama agar tidak mengalami kontra-produktif antara pemaknaan zahir/denotatif dan batin/konotatif. Para ulama hadis menyadari bahwa makna batin (ishari) tidak dapat ditolak, karena pemahaman ini didapatkan melalui perjalanan suluk, mujahadah dan riyadhah yang tidak mudah. Tidak semua kaidah-kaidah validitas terhadap pemaknaan ishari atas hadis. Diantara kaidah yang telah ditetapkan para ulama antara lain: 1) Pemaknaan ishari tidak boleh bertentangan dengan makna zahir, karena pada hakikatnya makna batin memperluas makna zahir. 2) Makna ishari tidak bertentangan dengan dalil syariat yang lain. Metode yang digunakan dalam penelitian ini adalah library research. Peneliti menggunakan literatur kepustakaan sebagai data dan analisa. Teknik content analysis dipilih sebagai teknik analisa dalam penelitian ini guna menjawab permasalahan yang dikaji.
'ADALAH AL-RAWI PERSPEKTIF SUNNI DAN SYI'AH
Authors: Ash Abil 
Published: February 2023

Sunni yang beranggapan bahwa semua sahabat itu adil. Sementara kelompok Syi’ah beranggapan sebaliknya, bahwa para sahabat tidak semuanya adil. Oleh karena itu, penulis melakukan penelitian tentang ‘adalah al-sahabat menurut Sunni dan Syi‘ah. Penelitian ini merupakan jenis penelitian kepustakaan (library research) dengan metode komparatif-analitis yaitu penulis memaparkan penjelasan umum tentang kajian ilmu hadis dan analisis terhadap kajian tersebut. Dalam penetapan keadilan para sahabat antara ulama Sunni dan Syi’ah sangat berbeda. Dalam penetapan tentang keadilan sahabat, ulama Sunni berargument bahwa predikat keadilan para sahabat itu bukan berdasarkan hasil ijtihad individu dan penelitian pada pribadi sahabat Nabi Saw, akan tetapi berdasarkan al-Qur’an, hadis, ijma ulama Sunni. Sedangkan ulama Syi’ah berargument seorang sahabat harus memenuhi syarat agar ia bisa dinyatakan sebagai sahabat yang ‘adil, diantaranya; Pertama, kekerabatan dan keturunan suci Nabi Muhammad Saw. Kedua, lebih dahulu menyatakan keimanan. Ketiga, tingkat ketakwaan. Keempat, tingkat keilmuan, khususnya ilmu agama. Kelima, mengakui kekhilafahan atas orang yang ditunjuk oleh Rasulullah Saw. Sebagai pemimpin syar’i pengganti dari Nabi Muhammad Saw. Tanpa disertai dengan rasa benci atau terpaksa. Persoalan keadilan sahabat ini termasuk salah satu hal yang sangat mendasar dalam studi ilmu keIslaman khhususnya ilmu hadis. ia akan berimplikasi kepada diterima atau ditolaknya sebuah hadis yang sekaligus juga sebagai sumber hukum Islam kedua tertinggi di dalam Islam setelah al-Qur’ān
IMPLEMENTASI GERAKAN LITERASI SEKOLAH DALAM PENGEMBANGAN MINAT MEMBACA DAN MENULIS SISWA KELAS IV DI SDN NGAWI PURBA 2
Authors: SUKARIYADI TEJA INSYAF , WIKANSO WIKANSO , WAHYUNINGSIH WAHYUNINGSIH 
Published: February 2023

The implementation of the School Literacy Movement (GLS) program is expected to be able to develop students' interest in reading and writing. This study aims to 1) determine the implementation of the School Literacy Movement in developing students' interest in reading and writing at SDN Ngawi Purba 2, and 2) find out the obstacles to implementing GLS at SDN Ngawi Purba 2. This type of research is descriptive qualitative. The subjects of this study were school principals, class teachers, and students. The research object is the implementation of the School Literacy Movement in developing students' interest in reading and writing which includes the habituation stage, the development stage and the learning stage. The method used in collecting data is in the form of interviews, observation, and documentation. The data analysis method uses the steps proposed by Miles and Huberman through data reduction, data presentation, conclusion and verification. The results of this study indicate that SDN Ngawi Purba 2 is a school that implements the GLS program. Students are required to read 15 minutes before learning begins. This program is in accordance with the policy rolled out starting in March 2016 by the Directorate General of Primary and Secondary Education of the Ministry of Education and Culture. SDN Ngawi Purba 2 hopes that by running this program the school will have a culture that will continue to be preserved. GLS is important to implement in order to develop students' interest in reading and writing.
ABSTRAKPelaksanaan program Gerakan Literasi Sekolah (GLS) diharapkan mampu mengembangkan minat membaca dan menulis siswa. Penelitian ini bertujuan untuk 1) mengetahui implementasi Gerakan Literasi Sekolah dalam mengembangkan minat membaca dan menulis siswa di SDN Ngawi Purba 2, dan 2) mengetahui hambatan implementasi GLS di SDN Ngawi Purba 2. Jenis penelitian ini adalah kualitatif deskriptif. Subjek penelitian ini adalah kepala sekolah, guru kelas, dan peserta didik. Objek penelitian berupa implementasi Gerakan Literasi Sekolah dalam pengembangan minat membaca dan menulis siswa yang meliputi tahap pembiasaan, tahap pengembangan dan tahap pembelajaran. Metode yang digunakan dalam mengumpulkan data berupa wawancara, observasi, dan dokumentasi. Metode analisis data dengan langkah-langkah yang dikemukakan oleh Miles dan Huberman melalui reduksi data, penyajian data, kesimpulan dan verifikasi. Hasil penelitian ini menunjukkan bahwa SDN Ngawi Purba 2 merupakan sekolah yang menerapkan program GLS. Siswa diwajibkan untuk membaca 15 menit sebelum pembelajaran dimulai. Program ini sesuai dengan kebijakan yang digulirkan mulai Maret 2016 oleh Direktorat Jendral Pendidikan Dasar dan Menengah Kemendikbud. SDN Ngawi Purba 2 berharap dengan menjalankan program ini sekolah mempunyai budaya yang terus dilestarikan. GLS penting untuk dilaksanakan guna mengembangkan minat membaca dan menulis siswa.