bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract P074: Pregnancy and neonatal outcomes among early-onset colorectal cancer survivors: a nationwide case-control study
Authors: Cao Yin , Zhao Stephanie , Bexelius Tomas S. , Söderling Jonas , Shi Mengyao , Roelstraete Bjorn , Warner Barbara B. , Stephansson Olof , Ludvigsson Jonas F. 
Published: January 2023

Abstract
Purpose: Early-onset colorectal cancer (CRC diagnosed before age 50) has risen worldwide, with an increasing number of survivors of reproductive age. We aimed to investigate the risk of adverse pregnancy and neonatal outcomes among early-onset CRC survivors. Methods: We conducted a nationwide case-control study of 207 births in women with early-onset CRC and 1019 births in women without CRC from the general Swedish population (1992-2019), matched on age, calendar year of birth, parity, and county of residence. To control for genetic susceptibility and shared childhood exposures, we additionally identified 146 births in female siblings of the CRC survivors. Early-onset CRC cases were identified through the Swedish Cancer Register (1969-2019), and siblings were identified through the Swedish Multi-generation Register. Maternal characteristics and neonatal outcomes were retrieved from the Swedish Medical Birth Register and National Patient Register. Using conditional logistic regression, we estimated adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Results: Compared to women without prior CRC, early-onset CRC survivors who gave birth had increased risk of pre-eclampsia (aOR 2.52, 95% CI 1.25 to 5.08), induced labor (aOR 1.64, 95% CI 1.09 to 2.46) and emergency Cesarean section (aOR 1.79, 95% CI 1.17 to 2.75), after adjustment for maternal education level, country of birth, body mass index and smoking in early pregnancy, and comorbidities. Sibling analyses showed similar trends, especially for higher risk of induced labor (aOR 2.58, 95% CI 1.03 to 6.49). Maternal history of early-onset CRC was also associated with offspring preterm birth (aOR 2.31, 95% CI 1.34 to 3.99) and low birth weight (aOR 2.95, 95% CI 1.40 to 6.21), and risks were particularly pronounced for medically indicated preterm birth (aOR 4.48, 95% CI 2.05 to 9.79). No significant associations were found for small for gestational age birth, low Apgar score, and congenital malformations. Conclusion: In this population-based study, history of early-onset CRC was associated with increased risk of adverse pregnancy outcomes, including pre-eclampsia, induction of labor, and emergency Cesarean section. Offspring to mothers with early-onset CRC also had increased risk of medically indicated preterm birth and neonatal low birth weight.
Citation Format: Yin Cao, Stephanie Zhao, Tomas S. Bexelius, Jonas Söderling, Mengyao Shi, Bjorn Roelstraete, Barbara B. Warner, Olof Stephansson, Jonas F. Ludvigsson. Pregnancy and neonatal outcomes among early-onset colorectal cancer survivors: a nationwide case-control study. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr P074.
Evaporated: Explorations in Art, Science, and Salt
Authors: Bowen Brenda B. , Wischer Wendy 
Published: January 2023

Abstract
Evaporated: Explorations in Art, Science, and Salt was a collaborative art exhibition that included sculptures, photographs, video, sound, and drawing, integrated with scientific data displays that encouraged the viewer to ponder the complexity of the Bonneville Salt Flats and our relationships to the landscape. This experimental exhibition was one of the outcomes from a five-year collaboration between geoscientist Brenda Bowen and artist Wendy Wischer exploring the rapidly changing Bonneville Salt Flats in northwest Utah through the lenses of both art and science. Evaporated provided an opportunity for both scholars to experiment with different ways of sharing their research, scholarly and creative, in the hopes of promoting understanding of the connections and differences between visual art and geoscience in academic contexts.
LASER Nomad: Road Maps for Art and Science Research into Ancestral Knowledge
Authors: Forcucci Luca 
Published: January 2023

Abstract
LASER Nomad is a mobile research laboratory for fieldwork. It is based in Berlin and run by UBQTLAB.ORG, a platform for arts and science research that produces talks, podcasts, and collaborative concerts in specific geographic sites. The focus is on the sonic arts to investigate epistemology emerging from arts, science, and technology as rituals in the context of indigenous knowledge and cybernetic systems. LASER Nomad aims to emphasize contemporary research melding into perception with ancestral knowledge and with nonclassical science. LASER Nomad forms part of the LASER network talks developed by Leonardo/ISAST and initiated by Piero Scaruffi.
Civil Limitation Statutes and International Arbitration in Central Asia: not Business as Usual
Authors: Bantekas Ilias 
Published: January 2023

Abstract
It is generally agreed that statutory limitations applicable to civil proceedings have no place in international arbitration proceedings, unless these have been specifically accepted by the parties; are imposed by mandatory laws, or; otherwise compelled by public policy. In equal measure, the process and recognition of enforcement awards should not be subjected to any statutory limitations, as such limitations are absent in the New York Convention and generally excluded by reference to transnational legal instruments, such as the uncitral Model Law. Investor and commercial actors operating in Central Asia should be cautious when embroiled in disputes with state entities because of the latter tend to protract and delay negotiations in order to impose statutory limitations to claims. It is imperative that upon commencement of negotiations foreign entities take appropriate measures to ensure that their claim is not undergoing a ticking time-ban. This may be achieved by serving the other party with an official notice as to the commencement of negotiations and a statement that this is not a substitute of a civil suit or arbitral proceedings. Equally, one of the parties may trigger arbitral proceedings but ask the arbitrators to suspend all hearings until after the termination of negotiations.
Taxonomic revision of the genus Spiranthes (Orchidaceae) in Taiwan
Authors: SUETSUGU KENJI , HSU TIAN-CHUAN 
Published: January 2023

The taxonomy of Spiranthes is highly challenging due to its phenotypic plasticity, morphological convergence, and hybridization. This paper presents a re-evaluation of the genus Spiranthes (Orchidaceae) in Taiwan, with special reference to the taxonomic identity of S. suishaensis that has often been considered the earlier name of S. nivea or S. hongkongensis. Nonetheless, the floral dissection of the type specimen revealed that S. suishaensis has a well-developed rostellum that separates the stigma and pollinarium of each flower, in contrast to autogamous taxa such as S. nivea and S. hongkongensis. Given the morphological evidence and that only S. sinensis was collected in the S. suishaensis type locality, we concluded that S. suishaensis is neither an earlier name for S. nivea nor S. hongkongensis but a synonym of S. sinensis. During morphological comparisons of S. suishaensis with other taxa of S. sinensis complex, we also found that the taxon illegitimately described as “S. minutiflora” could be treated as a variant of S. nivea. Given that it is distinguishable from S. nivea var. nivea by its more densely pubescent rachis and ovaries (vs. sparsely pubescent rachis and ovaries), narrower sepals with white tinged with pink or purple at apex (vs. wider and entirely white sepals), and papillose labellum disc (vs. almost glabrous labellum disc), we described it as a new variety of S. nivea, which we propose to name S. nivea var. papillata T.C. Hsu & Suetsugu. Consequently, we concluded that three species (S. sinensis, S. hongkongensis, and S. nivea [including var. nivea and var. papillata]) and one hybrid, S. australis × S. sinensis, occur in Taiwan.
Mental health symptoms and coping strategies among Ukrainians during the Russia-Ukraine war in March 2022
Authors: Xu Wen , Pavlova Iuliia , Chen Xi , Petrytsa Petro , Graf-Vlachy Lorenz , Zhang Stephen X. 
Published: January 2023

Context: The Russian attack on Ukraine has been ongoing since February 24, 2022. Nevertheless, no research has documented the mental health of Ukrainians during the biggest land war in Europe after the Second World War, or how Ukrainians cope with the impact of the war. Objectives: To provide the prevalence rates of symptoms of psychological distress, anxiety, depression, and insomnia; and to link them with Ukrainians’ productive coping strategies during the war. Design, setting, and participants: Online survey conducted in Ukraine during the initial period of the Russian invasion (March 19–31, 2022), using a quota sampling method, of 1,400 Ukrainians aged 18 years or older, with a total of 801 valid responses for a response rate of 57.2%. Main outcome measures: Psychological distress assessed by the Kessler Psychological Distress scale (K6); anxiety assessed by Generalized Anxiety Disorder-2 (GAD-2) scale; depression assessed by Patient Health Questionnaire-2 (PHQ-2); insomnia assessed by Insomnia Severity Index-4 (ISI-4); modes of coping assessed by Brief COPE. Results: Of 801 Ukrainian adults, 52.7% had symptoms of psychological distress (mean = 13.3 [ SD = 4.9]); 54.1% of them reported symptoms of anxiety (mean = 2.9 [ SD = 1.7]); 46.8% reported symptoms of depression (mean = 2.6 [ SD = 1.6]). Symptom criteria for insomnia were met by 97 respondents (12.1%) (mean = 10.4 [ SD = 4.2]). Demographic variables (including gender, living in an urban area, having children or elderly persons in the household, living in an area occupied by Russian forces) were associated with symptoms of distress, anxiety, depression, and insomnia. The productive coping strategies of using instrumental support, behavioral disengagement, self-distraction, and planning were significantly associated with mental health symptoms. Conclusions: Prevalence rates of symptoms of psychological distress, anxiety, depression, and insomnia were high. These findings underscore the need for healthcare and productive coping strategies for Ukrainians during the war.
Temporal resolution of photovoltaic electricity production with school energy consumption: a London primary school case study
Authors: Clochet Jean-Baptiste , Hong Sung-Min , Godoy-Shimizu Daniel 
Published: January 2023

In line with the UK goal to reach carbon neutrality by 2050, the combination of photovoltaic electricity and the electrification of heating systems is considered an effective way to reduce greenhouse gas emissions, while 88% of schools in the UK are gas-heated. This paper analyses the electricity consumption at a 15 and 30 min resolution of different scenarios for the retrofitting of a primary school in London, UK, with an electrified heating system and the electricity production of different PV installations. High temporal resolution allows consideration of economic balances, in light of rising costs of energy in the UK in 2022, and the possibilities PV can have on decarbonizing heating systems in UK primary schools. Practical application - The high temporal resolution allows to provide a project economic balance with close to reality figures. It also allows schools to rely on energy produced on site with less price fluctuation and to have the educational benefit of the PV installation. The high temporal resolution also provides data on what types of activities are the most energy consuming and can inform behaviour/time schedules changes.
Exosomal miR-202 derived from leukorrhea as a potential biomarker for endometriosis
Authors: Zheng Li , Sun Dai Fei , Tong Yanyan 
Published: January 2023

Objective Endometriosis (EMS) is a chronic gynecological disorder with an urgent need of a reliable non-invasive diagnostic strategy. Recently, there has been increasing interest in using the contents of exosomes, especially exosomal microRNAs (miRNAs), as potential biomarkers for various types of diseases. In this study, we assessed the differentially expressed miRNAs in exosomes derived from primary normal and ectopic endometrial cells. Methods We used miRNA microarray analysis to identify differentially expressed exosomal miRNAs. Among the selected exosomal miRNAs, we focused on hsa-miR-202-3p and hsa-miR-202-5p and validated their expression levels using quantitative reverse transcription polymerase chain reaction analysis. We then further examined their expression in exosomes derived from vaginal discharge (leukorrhea) from patients with EMS and the negative control group. Results The data show that hsa-miR-202-3p and hsa-miR-202-5p were expressed significantly higher in leukorrhea-derived exosomes from EMS patients compared with the negative controls. Conclusion Taken together, our results suggest that leukorrhea-derived exosomal hsa-miR-202 could serve as a potential useful biomarker for diagnosing EMS.
Foreign or Domestic? The Desecuritisation of Indian Affairs and Normativity in Securitisation Theory
Authors: Szarejko Andrew A. 
Published: January 2023

Is securitisation normatively undesirable? Many scholars who have studied this process by which issues come to be treated as pertaining to ‘security’ have argued that it is indeed preferable to keep as many issues as possible from being securitised. Rather, most issues ought to remain politicised such that they are seen as the legitimate subject of public debate. By contrast, I argue that we ought not to ascribe any inherent moral valence to securitisation or the reverse process of desecuritisation. Instead, each attempt to (de)securitise an issue ought to be debated on its own terms. To support my argument for the moral ambiguity of (de)securitisation, I examine the US Senate’s debate over whether to transfer the Bureau of Indian Affairs from the Department of War to a new Department of the Interior in 1849. I argue that this is an inflection point in a longer desecuritising process by which the United States – acting on a presumed hierarchy – coercively assimilated Native nations into its domestic political order. I conclude that scholars should not discard (de)securitisation as an analytical tool but can instead use work on (de)securitisation to inform public debate on the likely consequences of any particular (de)securitising move, thereby serving a chastening role in public discourse. Étranger ou national ? La désécuritisation des affaires indiennes et la normativité dans la théorie de la sécuritisation
Fibular- Versus Tibiofibular-Based Reconstruction of the Posterolateral Corner of the Knee: A Systematic Review and Meta-analysis
Authors: Boksh Khalis , Ghosh Arijit , Narayan Prithish , Divall Pip , Aujla Randeep 
Published: January 2023

Background: Fibular- and tibiofibular-based reconstructions are the gold standard treatment for posterolateral corner (PLC) injuries of the knee. Despite comparable outcomes in biomechanical studies, clinical results comparing these constructs remain elusive with no consensus reached regarding the best treatment option. Purpose: To perform a systematic review and meta-analysis to compare fibular- and tibiofibular-based techniques for posterolateral corner reconstruction. We aimed to identify whether any differences existed between the 2 techniques in terms of clinical outcomes and rotational and varus stability. Study Design: Meta-analysis; Level of evidence, 4. Methods: The Cochrane Controlled Register of Trials, PubMed, Medline, and Embase were used to perform a systematic review and meta-analysis using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria with the following search terms (“posterolateral corner” OR “fibular collateral ligament” OR “lateral collateral ligament” OR “popliteus tendon” OR “popliteofibular ligament”) AND (“reconstruction” OR “LaPrade” OR “Larson” OR “Arciero”). Data pertaining to all patient-reported outcome measures (PROMs), postoperative complications, and valgus and rotational stability were extracted from each study. The pooled outcome data were analyzed by random- and fixed-effects models. Results: After abstract and full-text screening, 6 clinical studies were included. In total, there were 183 patients, of which 90 received fibular-based and 93 tibiofibular-based reconstruction. The majority of studies used similar surgical techniques regarding tunnel orientation, attachment sites, and graft fixation sequence. There were no differences between the groups in terms of PROMs and subjective knee scores at a mean of 20.3 months. The techniques were equally effective in restoring varus and rotational stability. Subgroup analysis revealed that the stability of a posterior cruciate ligament reconstruction postoperatively was not affected by either construct. Conclusion: Both constructs had comparable clinical outcomes and were equally effective in restoring varus and rotational stability for PLC knee injuries. The fibular-based technique may offer advantages in view of being less technically demanding and invasive and requiring fewer grafts with a quicker operative time. However, higher quality studies are required to reinforce or refute such conclusions, as the majority of studies in this review were poor to fair quality.
Potential diagnostic role of circulating MiRNAs in colorectal cancer
Authors: Abo-elela Dina A , Salem Ahmed MH , Swellam Menha , Hegazy Marwa GA 
Published: January 2023

Objectives Colorectal cancer (CRC) is the third most common and fourth most deadly cancer worldwide despite its various screening method. Thus, the search for novel and better markers is continuous. This study aimed to assess the combined expression levels of miR-133a, miR-574-3p, and miR-27a in early diagnosis of colorectal cancer in comparison to traditional tumor markers (CEA and CA19.9). Methods miR-133a, miR-574-3p, and miR-27a were assessed in sera of 120 participants categorized into healthy control group ( n = 20), benign group ( n = 30) and malignant group ( n = 70) using real-time PCR. Results miR-133a, miR-574-3p, and miR-27a expressions showed significant difference among different staging, grading and tumor size of CRC. The sensitivities of the three miRNAs whether combined or individually used were better than routinely used tumor markers (CEA and CA19.9) leading to more accurate and faster diagnosis of CRC. Conclusion Synergetic detection of miRNA-133a, miRNA-574-3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.
Possible relationship between hydroxychloroquine and electrocardiographic and echocardiographic abnormalities in patients with inflammatory rheumatic diseases––a monocentric study
Authors: Pinheiro Filipe Oliveira , Martins Carvalho Miguel , Madureira Pedro , Seabra Rato Maria , Macedo Filipe , Costa Lúcia 
Published: January 2023

Objective Hydroxychloroquine (HCQ) is used in the treatment of inflammatory rheumatic diseases and is considered a safe drug. The role of HCQ in the COVID-19 pandemic highlighted some deleterious cardiac effects of HCQ. We aim to evaluate the prevalence and development of cardiac-adverse events in HCQ-treated patients with inflammatory rheumatic diseases. Methods We performed a cross-sectional study where patients aged ≥18 years with a diagnosis of inflammatory rheumatic disease currently exposed or not to hydroxychloroquine underwent electrocardiogram (ECG) and echocardiogram. Comparisons between groups were evaluated using chi-square, t test, and Mann-Whitney U test. Logistic regression was performed to determine predictors of changes in ECG and echocardiography. Results Eighty patients were included, 75 (93.8%) female, aged 52 ± 13 years. ECG changes were seen in higher proportion in patients with hypertension (40.6% vs 12.5%, p = .004) and higher median potassium levels—4.5 (4.1–4.8) versus 4.2 (4.0–4.4), p = .023. Echocardiography changes were seen in older patients (59 ± 11 vs 50 ± 13 years, p = .003) and in patients with higher cumulative dose—1752 (785–2190) versus 438 (328–1022) g, p = 0.008 – and time of exposure to HCQ – 12 (6–15) versus 4 (2–9) years, p = 0.028. HCQ cumulative dose (OR 1.001, CI95% 1.000–1.002, p = .033) and exposure time (OR 1.136, CI95% 1.000–1.289, p = .049) were predictors of echocardiography changes, but when adjusted for age, neither HCQ cumulative dose nor exposure time were predictors of echocardiography changes. Conclusion No association was found between changes in ECG and echocardiogram in patients under HCQ, which remains a safe drug in patients with inflammatory rheumatic diseases.
Dynamic mechanical properties and ageing studies of coir-sisal yarn reinforced polypropylene commingled composites
Authors: Anil Arya , E Tomlal Jose , George Gejo 
Published: January 2023

This work investigates the dynamic mechanical properties (DMA) and ageing behavior of coir-sisal yarn reinforced polypropylene commingled composites. Moreover, the fibres were subjected to various chemical treatments and their effects on DMA and ageing studies were investigated. DMA reveals that the chemical treatment, especially MAPP treatment, enhances the storage and loss modulus values on the other hand it diminishes the mechanical damping coefficient (tan δ) of the composite. Diffusion studies indicates that treated composites shows a much lower apparent percentage weight gain compared to other treated ones. Solar ageing studies shows that accelerated solar ageing deteriorated tensile strength and modulus of PP/coir-sisal yarn composite.
Social Model Hospice Residential Care Homes: Whom Do They Really Serve?
Authors: Melekis Kelly , Weisse Carol S. , Alonzo Jovanna D’ , Cheng Alice 
Published: January 2023

Background Most prefer to die at home, but the Medicare Hospice Benefit does not cover custodial care, making it difficult for terminally ill patients with housing insecurity and/or caregiver instability to access hospice care at home. Objectives To examine the characteristics of patients who received end-of-life care in community-run, residential care homes (RCHs) operating under the social model hospice. Methods A retrospective chart review of 500 residents who were admitted to one of three RCHs in Upstate New York over a 15-year period (2004-2019). Results Patients served by the RCHs included 318 (63.6%) women and 182 (36.4%) men aged 34-101 (M = 77.8). The majority (94.9%) were Caucasian and most had cancer diagnoses (71.6%). Prior to admission, most (93%) patients resided in a private residence, and nearly half (47%) lived alone, but most (81.7%) had full- or part-time caregivers. Nearly all patients were admitted either directly from a hospital (47.5%) or private home (47.2%). Over half (52%) were admitted to RCHs within a month of hospice enrollment, and 20.1% enrolled concurrent with admission. While the average length of stay was 21 days, 50% died within 10 days of admission. Conclusions Community-run RCHs represent a unique approach for improving access to hospice home care for patients with home insecurity and/or caregiver instability, yet most patients had prior caregiver coverage and were admitted from a hospital or home setting, suggesting there is a need for community care settings for patients unable to remain at home in the final weeks or days prior to death.