bluuebunny/crossref_metadata_2025_split huggingface dataset:
АНАЛИЗ ИСПОЛЬЗОВАНИЯ АВТОМАТИЗИРОВАННЫХ СИСТЕМ УПРАВЛЕНИЯ ОТЕЧЕСТВЕННЫМИ ПРЕДПРИЯТИЯМИ
Authors: Влад Михаил Михайлович , Куликов Михаил Михайлович 
Published: March 2023

Целью исследования является выявление преимуществ использования автоматизированных систем управления предприятиями.
Методологическую базу исследования составляют статистические данные российских рейтингов использования ERP-систем, научные статьи и публикации, теоретические труды, практические разработки отечественных и зарубежных ученых, статистические наблюдения и элементы сравнительного анализа. Рассмотрение, изучение и использование данных материалов позволяет оценить перспективы использования российских автоматизированных систем управления предприятиями.
Результаты исследования. Рассмотрены этапы и особенности развития автоматизированных систем управления предприятием. Представлены понятия, сущность и функции ERP-систем. Проанализирован жизненный цикл ERP-системы и расходы, возникающие на каждом из этапов. Представлены основные преимущества внедрения автоматизированных систем управления в контексте повышения конкурентоспособности предприятий. Приведены примеры внедрения данных систем на отечественных предприятиях.
Перспективой исследования является рассмотрение и выявление перспектив использования российских автоматизированных систем управления предприятиями.
Analysis of somatic mutations in the <i>JAK2</i>, <i>CALR</i>, <i>MPL</i> and <i>ASXL1</i> genes and evaluation of their impact on the survival of patients with myelofibrosis
Authors: Subbotina T. N. , Maslyukova I. E. , Semashchenko K. S. , Khodos G. A. , Kurochkin D. V. , Shalyova A. A. , Mikhalev M. A. , Vasiliev E. V. , Osadchaya M. G. , Dunaeva E. A. , Esman A. S. , Mironov K. O. 
Published: March 2023

Background. The development of myelofibrosis (MF) is driven by complex molecular genetic events that include driver somatic mutations responsible for the constitutive activation of the JAK/STAT signaling pathway (JAK2, CALR, and MPL), additional mutations affecting epigenetic regulators (TET2, ASXL1, IDH1/2, etc.) and RNA splicing (SRSF2, U2AF1, SF3B1, etc.), as well as genetic aberrations that contribute to genomic instability and disease progression.Aim. To analyze driver (JAK2, CALR, MPL) and prognostic (ASXL1) somatic mutations in patients with MF and evaluate their impact on survival.Materials and methods. The study included 29 patients diagnosed with MF, selected by hematologists from the City Clinical Hospital No. 7 and Regional Clinical Hospital (Krasnoyarsk).Results. 26 (89.6 %) out of 29 examined patients had some driver mutations in JAK2, CALR, MPL genes. The p.V617F mutation in the JAK2 gene was found in 20 (68.9 %) patients. Mutations in the CALR gene were detected in 4 (13.8 %) patients, mutations in the MPL gene were found in 3 patients (10.3 %). In 1 of 26 patients, 2 driver mutations were present simultaneously. 3 (10.3 %) patients were triple negative. Mutations in the ASXL1 gene were detected in 12 (41.4 %) out of 29 examined patients. Conducted targeted NGS (next generation sequencing) for 13 out of 29 patients revealed additional genetic variants that contribute to the understanding of the development mechanism and disease course. When evaluating the overall survival in the groups of patients diagnosed with MF examined by us, depending on the combination of driver (JAK2, CALR, MPL) and prognostic (ASXL1) mutations, no statistically significant differences were found (p = 0.12). This appears to be due to the small sample size. At the same time, assessment of patient survival depending on ASXL1 status showed that in the presence of mutations in the ASXL1 gene, the median survival was 45 months (range 7–120 months), while in the absence of mutations it was 48 months (range 21–359 months) (p = 0.03).Conclusion. The results obtained allow us to assume that the presence of mutations in the ASXL1 gene is an unfavorable factor in the course of the disease.
Keterampilan Memberi Penguatan dalam Pembelajaran di Kelas V SD
Authors: Hizbullah Hizbullah , Muchtar Muchtar , Mahanani Putri 
Published: March 2023

Abstract: The skill of giving reinforcement is one of the basic teaching skills that is very important to be mastered by the teacher. Reinforcement is any form of response that is part of the modification of the teacher's behavior on student behavior, which aims to provide information or feedback for students on the actions of the responses given. as an encouragement or correction. Strengthening skills provided by the teacher, students will feel compelled forever to respond whenever an activity appears from the teacher, or students will try to avoid responses that are considered useless. The purpose of this study was to determine the skills of teachers in providing verbal and non-verbal reinforcement in class V SDN Kotalama 2. This study used descriptive qualitative research. Data collection techniques in the form of observation, interviews, documentation, and instruments. The research subjects were classroom teachers, religion teachers, and fifth grade students at SDN Kotalama 2. The results showed that the skills to provide reinforcement in learning in grade V at SDN Kotalama 2 had been implemented well. The skill of giving reinforcement is carried out by the teacher in every learning that takes place. However, it was also found that several barriers to the skills of providing reinforcement from both classroom and religious teachers were found to be less than optimal.
Abstrak: Keterampilan memberi penguatan merupakan salah satu keterampilan dasar mengajar yang sangat penting untuk dikuasai oleh guru, Penguatan adalah segala bentuk respon yang merupakan bagian dari modifikasi tingkah laku guru terhadap tingkah laku siswa, yang bertujuan untuk memberikan informasi atau umpan balik bagi siswa atas perbuatan responnya yang diberikan sebagai suatu dorongan atau koreksi. Keterampilan penguatan yang diberikan guru, maka siswa akan merasa terdorong selamanya untuk memberikan respon setiap kali muncul kegiatan dari guru, atau siswa akan berusaha menghindari respon yang dianggap tidak bermanfaat. Tujuan penelitian ini untuk mengetahui keterampilan guru dalam memberi penguatan verbal dan non-verbal dalam pembelajaran dikelas V SDN Kotalama 2. Penelitian ini menggunakan penelitian kualitatif deskriptif. Teknik pengumpulan data berupa observasi, wawancara, dokumentasi, dan instrument. Subjek penelitian adalah guru kelas, guru agama, dan siswa kelas V SDN Kotalama 2. Hasil menunjukan bahwa keterampilan memberi penguatan dalam pembelajaran di kelas V SDN Kotalama 2 sudah dilaksanakan dengan baik. Keterampilan memberi penguatan dilakukan oleh guru disetiap pembelajaran berlangsung. Namun, ditemukan juga beberapa hambatan terhadap keterampilan memberi penguatan baik dari guru kelas maupun guru agama yang kurang maksimal.
Menumbuhkan Kesadaran Siswa Terhadap Bahaya Merokok Melalui Konseling Kelompok Realita
Authors: Firmansyah Agus Zaqi 
Published: March 2023

Abstract: Smoking culture among students today can not be filtered out as the purpose of toxins in cigarette filters. The presumption dashing if cigarette smoking is the main cause of their doing so. But it is obvious that there are school rules forbid it. Many students do smoke because already has a previous perception about cigarettes, either from family, advertising, as well as from her social friends. Mild sanctions for students will not be deterrent for those who smoke at school. guidance and counseling in schools is crucial in stemming the behavior of current students. Such behavior can be handled using group counseling reality, because in principle now focuses on behavior and is a form of behavior modification. With group counseling students will interact directly with members of other groups. The interaction of the group aims to increase understanding and acceptance of the values so as to reduce or even eliminate the attitudes and behavior of the smoking habit.
Abstrak: Budaya rokok dikalangan pelajar sampai saat ini tidak dapat difilter sebagaimana tujuan filter menyaring racun dalam rokok. Anggapan gagah jika menghisap rokok adalah menjadi penyebab utama mereka melakukannya. Padahal jelas aturan yang ada disekolah melarangnya. Banyak pelajar melakukan merokok dikarenakan sudah mempunyai persepsi sebelumnya tentang rokok, baik dari keluarga, iklan, maupun dari teman pergaulannya. Sanksi yang ringan bagi pelajar tidak akan menimbulkan efek jera bagi mereka yang merokok di sekolah. bimbingan dan konseling di sekolah sangatlah penting dalam membendung perilaku pelajar saat ini. Perilaku tersebut dapat ditangani menggunakan konseling kelompok realita, karena pada prinsipnya berfokus pada tingkah laku sekarang dan merupakan bentuk modifikasi perilaku. Dengan konseling kelompok siswa akan berinteraksi langsung dengan anggota kelompok lain. Interaksi kelompok tersebut bertujuan untuk meningkatkan pengertian dan penerimaan terhadap nilai sehingga mampu mengurangi bahkan menghilangkan sikap-sikap serta perilaku kebiasaan merokok tersebut.
Pelaksanaan Keterampilan Bertanya pada Pembelajaran Tematik di SD
Authors: Abibah Khofifah Nila , Cholifah Puri Selfi , Umayaroh Siti 
Published: March 2023

Abstract: Questioning skills play an important role for teachers in the learning process as an assessment tool for students and as a means of interaction from teacher to student and student to teacher. This study aims to describe the implementation of basic and advanced questioning skills and describe student responses to the implementation of basic and advanced questioning skills in thematic learning at SDN Polehan 4 Malang. This study uses a mix method. The subjects of this study consisted of 5 respondents. Quantitative data was obtained from the results of observation data carried out during the thematic learning process, then qualitative data were obtained from the results of interviews and documentation. The results of the study show that basic questioning skills are used more often than advanced questioning skills. The basic questions that arise are the components of clear and concise questions, shift shifts, and question distribution. While the components of advanced questioning skills that appear are the sequence of questions and tracking questions. Students' responses to the implementation of asking skills in thematic learning are that some actively respond and some do not actively answer questions, but most students actively respond to teacher questions because teachers always give awards. When answering questions from the teacher, students tend to give short answers that require a low level of thinking.
Abstrak: Keterampilan bertanya memegang peranan penting bagi guru dalam proses pembelajaran sebagai alat penilaian kepada siswa serta sebagai alat interaksi dari guru ke siswa dan siswa ke guru. Penelitian ini bertujuan untuk mendeskripsikan mengenai pelaksanaan keterampilan bertanya dasar dan lanjut serta mendeskripsikan respon siswa terhadap pelaksanaan keterampilan bertanya dasar dan lanjut pada pembelajaran tematik di SDN Polehan 4 Malang. Penelitian ini menggunakan mix method. Subjek penelitian ini terdiri dari 5 responden. Data kuantitatif diperoleh dari hasil data observasi yang dilaksanakan selama proses pembelajaran tematik, kemudian untuk kualitatif diperoleh dari hasil wawancara dan dokumentasi. Hasil dari penelitian menunjukkan bahwa keterampilan bertanya dasar lebih sering digunakan dibandingkan keterampilan bertanya lanjut. Pertanyaan dasar yang muncul adalah komponen pertanyaan yang jelas dan singkat, pemindahan giliran, dan penyebaran pertanyaan. Sedangkan komponen keterampilan bertanya lanjut yang muncul adalah urutan pertanyaan dan pertanyaan pelacak. Respon siswa terhadap pelaksanaan keterampilan bertanya pada pembelajaran tematik yaitu ada yang aktif merespon dan ada yang tidak aktif menjawab pertanyaan, namun sebagian besar siswa aktif merespon pertanyaan yang guru karena guru selalu memberikan penghargaan. Saat menjawab pertanyaan dari guru siswa cenderung memberikan jawaban singkat yang memerlukan tingkat berpikir rendah.
Work stress among physicians, dubai health authority, in the year 2018-2019
Authors: Ahmad H. , Mubarak F. , Almaftool W. 
Published: March 2023

Background: Work stress is a significant problem that affects physicians. Multiple sources can contribute to this problem. High-stress rates among physicians can manifest in various expressions, including cognitive, behavioral, and somatic expressions. Work performance and quality of medical care administered to patients can be undermined by over-stressed physicians. The study aimed to assess the prevalence of stress among physicians working in governmental health facilities in Dubai (2018-2019) and their relationship with socio-demographic and job factors. Methods: It is a cross-sectional study. This study population includes all physicians practicing in Dubai Health Authority hospitals and primary health care centers in the Year 2018-2019. Target Number is 1337 taken from the registry of Dubai health authority administration, but only 668 questionnaires were included with a RR of 49.9%. The data tool used in this study is a modified self-administered questionnaire from both validated health and safety executive (Barbaranelli et al., 2018) occupational stress and stress questionnaire by International Stress Management Association UK 2013. It consists of 22 items which were divided into demographic, stress indicators, factors, and other domains. They were distributed as hard copies by hand. Findings: The study concluded that 40.2% were more likely to experience stress, while 59.8% were most prone to stress. Furthermore, the study showed a strong association with different factors such as the role of managers, shift duty, and multi-task work. Conclusion: Work stress is a prevalent problem among physicians working at Dubai health authority. The stress is associated with factors: such as multi-task work, shift hours’ duties, time pressure, and the role of line manager. Implications for Occupational Health Nursing Practice or Implications for Occupational Health Practice: Healthier working environment will promote the well-being of its staff and ensure the proper delivery of care to the community.
In silico Study to Investigate Targeting Ability of Genistein against Fatty acid binding protein 4 (FABP4) in Peripheral Artery Disease
Authors: Dongre S. , Shah N. , Sharma T. 
Published: March 2023

“Peripheral artery disease” or PAD, is considered as a most prevalent condition, and it commonly coexists with vascular diseases in other body parts. The epidemiology of PAD is well known and connected to age and, particularly, the predisposing factors of smoking and diabetes mellitus. Diagnosis on early basis is important for enhancing the quality of life (QOL) in addition to the reducing risk for the development of significant subsequent vascular events such as “acute myocardial infarction (AMI)” or “stroke”. There are a variety of treatments used to manage and treat the disease. However, there are negative effects and toxicities associated with that treatment in addition to higher costs. Hence, a surge in the hunt for natural compounds of botanical origin is gaining traction. The present study aims at exploring the targeting ability of phytocompound, and genistein against FABP4 which is an emerging target for PAD in diabetes patients. The study is conducted using a computation method employing Autodock4 and other accessory tools. The results of the docking process revealed a significant binding energy of -6.14 which demonstrated a stable complex formation between protein and selected compound. Thus, showing great potential for the treatment of PAD.
Hyperphosphatemia-a predictor of poor prognosis among patients with sepsis or septic shock
Authors: A. Rakshith , C. Yogitha , S. Basanth Kumar 
Published: March 2023

Background: Sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infection. Serum phosphorus level was closely related to the occurrence and prognosis of kidney disease and cardiovascular disease. It is of vital importance to re-evaluate the association between serum Phosphorus level and mortality in patients with sepsis and different septic subgroups. This study aims to examine the association of serum phosphorous levels with clinical outcomes among patients with sepsis.
Methods: This study included 100 cases and was conducted at KIMS hospital Bangalore. Patients were included in the study as per inclusion criteria. SOFA scoring and APACHE-II scoring was done on first day of admission and serum phosphorus levels were sent. Patients were categorised according to phosphorous levels normal range (2.5-4.5mg/dl). Patients were followed up till primary and secondary outcome.
Results: Of the 100 patients in this study 53 patients had normophosphatemia, 17 patients had hypophosphatemia, 30 patients had hyperphosphatemia. Comparison of mean APACHE-II scores, mean length of ICU stay (in days), mean length of hospital stay (in days), serum creatinine levels, between 3 groups was statistically significant.
Conclusions: Hyperphosphatemia on first ICU admission day indicates poor clinical outcome among patients with sepsis or septic shock. Therefore, when patients are on ICU admission and under treatment, clinicians should pay more attention to the change of serum phosphate.
Study of refrigerated storage of blood at 4°C on automated hematological parameters & morphological changes in peripheral blood smear: A prospective study
Authors: Kadam Poornima , Patil Nikhita , Mane Vaibhav P 
Published: March 2023

: Complete hemogram & peripheral blood smear are primary tests done in day to day practice for correct diagnosis & further treatment of patients. EDTA blood samples are used for this regular screening tests which shows less stability in case of delaying sampling. Hence, the final results of these tests can be affected by different storage conditions & duration. This present study provides data analyzed from EDTA blood samples stored upto 24 hour at both room temperature & 4°C refrigeration.This study includes total 150 blood samples from indoor & outdoor patient without any specific criteria which were collected randomly. These blood samples were analyzed using haematological analyzer for complete blood count & their peripheral smear after storage in both room temperature & 4°C refrigeration for 24 hrs. There was significant increase in MCV & decrease in MCHC, reduced WBC count & platelet count with storage at room temperature which was prohibited by refrigeration. However, both room temperature & refrigerated storage does not affect RBC count & hemoglobin.Blood samples stored at room temperature for 24 hrs results in changes in haematological parameters & morphology of cells. Hence, refrigerated storage at 4°C is recommended for accurate results in case evaluation of delayed samples.
Sarcomas in fluid cytology: Experience from a tertiary care centre in India
Authors: Samanta Satarupa , Kapoor Shilpa , Kaur Kanwalpreet , Maru Paheli , Trivedi Priti 
Published: March 2023

Cytological evaluation of fluids for sarcomatous exfoliation is extremely rare. However, recently studies have come up describing characteristics of sarcomatous malignancies exfoliating into fluids but study from an Indian experience is still lacking. Description of clinico-pathological landscape in known cases of sarcomas, involving body fluid with emphasis on cytomorphologic details. Study includes cases reported as positive for involvement by sarcoma on fluid cytology including pleural, ascitic and cerebrospinal fluid (CSF) specimens between Jan 2016 to June 2022. Cases were retrieved and reviewed for cytomorphologic features which were subsequently correlated with its parent histology and IHC. IHC was applied on cell blocks for two cases where involvement was doubtful. In total, 21 fluid samples/cases including 4 CSF, 6 ascitic and 11 pleural fluid specimens were incorporated. Case spectrum comprised of 6 cases of Ewing Sarcoma (ES), 3 cases of rhabdomyosarcoma (RMS), 3 cases of osteosarcoma (OS), 2 cases of malignant peripheral nerve sheath tumor (MPNST), 2 cases of synovial sarcoma (SS), a case each of chondrosarcoma (CS), leiomyosarcoma (LMS) angiosarcoma (AS) and two cases of other malignancies with exfoliation of their sarcomatous component. Two cases presented as isolated latent metastasis so an IHC panel was applied to exclude involvement by secondary malignancy and prove involvement by primary diagnosed sarcoma.Majority of exfoliated sarcomas presented with epithelioidto pleomorphic morphology where at times it becomes obligatory to rule out occurrence of a secondary malignancy. It’s the first study from an Indian institute’s perspective that reflects upon such diversity of sarcomas with variability in morphology on exfoliation which can be overwhelming for a cytopathologist at times. IHC panel might be used when clinical background is unknown or when involvement is uncertain. More studies are needed that can help come up with recommendations that address such problems.
Role of hematological and inflammatory marker in granulomatous compared to non-granulomatous lymphadenitis
Authors: Ahmad Faiyaz , Samin Faiza , Mittal Ankita , Awasthi Seema , Nasir Ariba 
Published: March 2023

Lymphadenopathy can result due to an increase in lymphocytes in the lymph node due to various infections like tuberculosis and lymphoproliferative conditions. Granulomatous lymphadenitis causes an increase in inflammatory biomarkers which can be assessed by simple hemogram using TLC and DLC and ratios derived from it like NLR (Neutrophil Lymphocyte Ratio) and PLR (Platelet Lymphocyte Ratio). To establish the role of hematological and inflammatory biomarkers in granulomatous and non-granulomatous lymphadenitis.The study was performed in a tertiary care center from august 2020 to September 2022. The study included 150 patients with neck mass taking inclusion and exclusion criteria into account. Cytologically proven cases were categorised into granulomatous and non-granulomatous cases depending on cytological evaluation. Different laboratory parameters like TLC, DLC, ESR, CRP, NLR, and PLR were used to compare granulomatous lymphadenitis to non-granulomatous.In the studied population there were 92(61.3%) females and 58(38.7%) males but when compared to the non-granulomatous lymphadenitis group, females predominated by 70.7% hematological markers like NLR, PLR, and CRP in the granulomatous lymphadenitis group was significantly higher. The mean Neutrophil was considerably higher among granulomatous lymphadenitis but in non-granulomatous lymphadenitis, the group showed considerably greater mean lymphocytes.Tuberculosis is the most frequent clinical condition connected to cervical lymphadenopathy in our area. More often than not, women are involved. Hematological and biochemical parameters like NLR, PLR, and CRP can give us some indication before FNAC for the presence of granulomatous and non-granulomatous lymphadenitis. It will help the treating doctor think methodically about early case identification and avoid diagnostic delays in situations like tuberculosis, especially at the primary care level.