bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of risk on capital structure adjustments: Evidence from the African markets
Authors: Amelot Lydie Myriam Marcelle , Subadar Agathee Ushad , Seetanah Boopendrah 
Published: May 2023

AbstractEmploying panel data analysis, the study investigated the impact of risk on speed and costs of adjustments on target leverage on listed firms from the African markets—a panel data set of 2790 observations for 12 years spanning from 2008 to 2019. Based on the results of the Unit root test and Granger causality test, there are bidirectional relationships between risk and capital structure and vice versa. Additionally, Panel DOLS and System GMM were applied for regression and comparison analysis between the African markets and South Africa. The estimates disclose that when companies experience lower risk, the costs of adjustment toward the target are higher. Hence, companies can re‐adjust their capital structure more easily by issuing external capital over periods of stable economic environments, thereby improving their market value. Considering the case of South Africa, the first DOLS results outlined similar estimates compared to the African market. Conversely, when measured with System GMM, the estimates imply that firms incur difficulties in adjusting costs, thus reducing leverage due to unfavorable macroeconomic indicators in line with the pecking order theory stating that in African economies, companies spend more on expenses and adjust their capital structure slowly to reach their optimal target position.
Identifying nostalgia in text: The development and validation of the nostalgia dictionary
Authors: Chen Jia , Layous Kristin , Wildschut Tim , Sedikides Constantine 
Published: May 2023

AbstractNostalgia is a prevalent emotion that confers psychological benefits and influences consumer behavior. We developed and validated the 98‐word Nostalgia Dictionary to automatize the assessment of nostalgicity in narratives (e.g., customer reviews, social media). First, we created an initial wordlist by identifying the most frequently used words in nostalgia narratives and by relying on the nostalgia literature. Second, we finalized the dictionary by testing experimentally the expanded wordlist for its capacity to differentiate nostalgia from related emotions. Third, we validated the dictionary by demonstrating that it corresponds to self‐reports and coder‐ratings of nostalgia, produces result patterns expected by theory, and predicts favorability ratings of books and consumer experiences, even after adjusting for positive emotion words. We discuss the potential of the Nostalgia Dictionary to advance research and practice.
The Efficacy of Superior Laryngeal Nerve Block for Neurogenic Cough: A Placebo‐Controlled Trial
Authors: Tipton Courtney B , Walters Rameen , Gudipudi Rachana , Smyre Drasti , Nguyen Shaun , O'Rourke Ashli K 
Published: May 2023

ObjectivesChronic cough is a common and debilitating problem. The objective of this study is to assess the efficacy and safety of superior laryngeal nerve (SLN) block for neurogenic cough through a placebo‐controlled, prospective trial.MethodsPatients were recruited in an outpatient tertiary care center. Inclusion criteria included a history consistent with neurogenic cough and age ≥ 18. Exclusion criteria included patients with untreated other etiologies of chronic cough (i.e., uncontrolled reflux) and current neuromodulating medication use. Patients were randomized into the treatment (1–2 mL of a 1:1 triamcinolone 40 mg: 1% lidocaine with 1:200,000 epinephrines) or placebo (saline) group and received two unilateral injections at approximately 2‐week intervals. Outcomes were measured primarily by the Leicester Cough Questionnaire (LCQ) and a patient symptom log including a visual analog scale of cough severity.Results17 patients completed the study, including 10 in the treatment group and seven in the placebo group. Eight (80%) patients in the treatment group reported improvement with at least one of the injections, whereas only 1 (14.3%) patient reported improvement in the placebo group (p < 0.0001). Average total LCQ scores increased in the treatment group from 10.09 to 13.15 (p = 0.03), with the most change occurring in the social domain. There was no statistically significant change in LCQ scores for the placebo group. There were no serious adverse events.ConclusionAn SLN block is a safe and efficacious procedure for the treatment of neurogenic cough. Further studies are needed to optimize treatment protocol and assess long‐term follow‐up of patient outcomes.Level of Evidence2 Laryngoscope, 133:3068–3074, 2023
Total alkalinity measurement using an open‐source platform
Authors: Sandborn Daniel E. , Minor Elizabeth C. , Hill Craig 
Published: May 2023

AbstractTotal alkalinity is a pivotal water quality parameter dictating the response of natural waters to acid–base system perturbations such as ocean acidification and acid mine drainage. Its value as a biogeochemical and ecological variable is enhanced not just by high measurement quality, but also by measurement accessibility. This research demonstrates an instrument that advances the accessibility of high‐precision, high‐accuracy total alkalinity measurement using open‐source, and low‐cost instrumentation. Repeated testing of water samples from Lake Superior demonstrated a measurement precision (standard deviation or SD) of 3.0 μmol kg−1. Analysis of standards and reference materials demonstrated an uncertainty of 5.3 μmol kg−1 as well as robustness to freshwater and saltwater matrices. This instrument adds to the wealth of inorganic carbon measurement technologies in marine and lacustrine settings and stands to enhance the ability of both communities to generate accurate and accessible measurements of total alkalinity.
The power set and the set of permutations with finitely many non‐fixed points of a set
Authors: Shen Guozhen 
Published: May 2023

AbstractFor a cardinal , we write for the cardinality of the set of permutations with finitely many non‐fixed points of a set which is of cardinality . We investigate the relationships between and for an arbitrary infinite cardinal in (without the axiom of choice). It is proved in that for all infinite cardinals , and we show that this is the best possible result.
Far upstream element‐binding protein 1 confers lobaplatin resistance by transcriptionally activating PTGES and facilitating the arachidonic acid metabolic pathway in osteosarcoma
Authors: Ma Qiong , Sun Jin , Wang Huan , Zhou Chengpei , Li Chenyu , Wu Yonghong , Wen Yanhua , Zhang Xiaoyu , Ren Xingguang , Guo Zheng , Gong Li , Zhang Wei 
Published: May 2023

AbstractDrug resistance is a major obstacle in cancer treatment and recurrence prevention and leads to poor outcomes in patients suffering from osteosarcoma. Clarification of the mechanism of drug resistance and exploration of effective strategies to overcome this obstacle could lead to clinical benefits for these patients. The expression of far upstream element‐binding protein 1 (FUBP1) was found to be markedly elevated in osteosarcoma cell lines and clinical specimens compared with osteoblast cells and normal bone specimens. High expression of FUBP1 was correlated with a more aggressive phenotype and a poor prognosis in osteosarcoma patients. We found that overexpression of FUBP1 confers lobaplatin resistance, whereas the inhibition of FUBP1 sensitizes osteosarcoma cells to lobaplatin‐induced cytotoxicity both in vivo and in vitro. Chromatin immunoprecipitation‐seq and RNA‐seq were performed to explore the potential mechanism. It was revealed that FUBP1 could regulate the transcription of prostaglandin E synthase (PTGES) and subsequently activate the arachidonic acid (AA) metabolic pathway, which leads to resistance to lobaplatin. Our investigation provides evidence that FUBP1 is a potential therapeutic target for osteosarcoma patients. Targeting FUBP1, its downstream target PTGES and the AA metabolic pathway may be promising strategies for sensitizing chemoresistant osteosarcoma cells to lobaplatin.
Parkin Maintains Robust Pacemaking in Human Induced Pluripotent Stem Cell‐Derived A9 Dopaminergic Neurons
Authors: Pu Jiali , Lin Lin , Jiang Houbo , Hu Zhixing , Li Hong , Yan Zhen , Zhang Baorong , Feng Jian 
Published: May 2023

AbstractBackgroundThe degeneration of nigral (A9) dopaminergic (DA) neurons results in cardinal motor symptoms that define Parkinson's disease (PD). Loss‐of‐function mutations in parkin are linked to a rare form of early‐onset PD that is inherited recessively.ObjectiveWe generated isogenic human A9 DA neurons with or without parkin mutations to establish the causal relationship between parkin mutations and the dysfunction of human A9 DA neurons.MethodsUsing TALEN (transcription activator‐like effector nuclease)‐ or CRISPR/Cas9‐mediated gene targeting, we produced two isogenic pairs of naivetropic induced pluripotent stem cells (iPSCs) by repairing exon 3 deletions of parkin in iPSCs derived from a PD patient and by introducing the PD‐linked A82E mutation into iPSCs from a healthy subject. The four lines of isogenic iPSCs were differentiated to A9 DA neurons, which fired spontaneous pacemaking action potentials (AP) dependent on L‐type Ca2+ channels.ResultsThe frequency of the pacemaking APs was significantly reduced by parkin mutations introduced to normal neurons. Consistent with this, isogenic repair of parkin mutations significantly increased the frequency from that observed in patient‐derived neurons.ConclusionsThe results show that parkin maintains robust pacemaking in human iPSC‐derived A9 DA neurons. The function is critical to normal DA transmission required for controlling voluntary locomotor activities. © 2023 International Parkinson and Movement Disorder Society.
Patient with severe acute respiratory syndrome coronavirus 2 nosocomial infection undergoing superselective intra‐arterial chemoradiation therapy for maxillary gingival carcinoma: A case report
Authors: Koizumi Toshiyuki , Ohya Takashi , Oguri Senri , Iwai Toshinori , Kioi Mitomu , Mitsudo Kenji 
Published: May 2023

AbstractBackgroundThe ongoing coronavirus disease 2019 (COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, has changed cancer treatment. However, specific guidelines for patients with oral cancer and SARS‐CoV‐2 infection, especially for chemoradiation therapy (CRT), are lacking.Case PresentationWe report a case of a woman with oral squamous cell carcinoma diagnosed with SARS‐CoV‐2 nosocomial infection, although she had no COVID‐19 symptoms, while undergoing superselective intra‐arterial CRT. She received sotrovimab while continuing CRT and achieved a complete response.ConclusionThe general condition of the patient and the CRT regimen characteristics should be considered in the treatment of patients with COVID‐19 and cancer.
Covalent grafting of zwitterion polymer and REDV peptide onto NiTi alloy surface for anticoagulation and proendothelialization
Authors: Wang Meiyu , Wan Ye , Liu Wen , Gao Bin , Wang Xiaoyu , Li Wenzhong , Xia Shihai , Zhang Wencheng , Wang Kai , Feng Yakai 
Published: May 2023

AbstractAlthough stent implantation is an effective treatment for cardiovascular diseases, restenosis and thrombosis still remain great challenges clinically. To address these problems, modifying the stent surface with the bifunctions of anticoagulation and proendothelialization is considered as a promising strategy. Herein, zwitterion polymer poly (α‐methacrylic acid‐co‐2‐methylacryloxyethyl phosphorylcholine) (PMAMPC) and endothelial cells (ECs)‐selective adhesion peptide REDV were co‐modified onto the surface of NiTi stent by chemical graft to obtain NiTi‐PMAMPC/REDV stent. The introduction of PMAMPC and REDV peptide equip NiTi‐PMAMPC/REDV stent with satisfactory anticoagulation performance and enhanced endothelialization, respectively. The in vitro studies showed that NiTi‐PMAMPC/REDV surface had excellent blood compatibility, and could effectively promote the adhesion, proliferation and migration of human umbilical vein endothelial cells (HUVECs). Additionally, NiTi‐PMAMPC/REDV surface were capable of decreasing the adhesion of smooth muscle cells (SMCs). In vivo studies demonstrated that the NiTi‐PMAMPC/REDV stent could maintain good blood patency and form a relatively complete endothelial layer on the surface after 30 days in the rat aorta model. This bifunctional surface might hold great potential in relieving thrombosis and restenosis in the field of stent implantation.
Stereospecific radical polymerization of methacrylate bearing oxazolidone structure and improvement of glass transition temperature of urethane methacrylate copolymers
Authors: Yoshinaga Yuki , Yoshida Yoshiaki 
Published: May 2023

AbstractWe synthesized the novel methacrylate monomer bearing an oxazolidone structure (M1) and performed radical polymerization of M1 by traditional procedures. The glass transition temperature (Tg) of the obtained polymer (P1) was a significantly high value compared to that of poly(methyl methacrylate) and typical poly(urethane methacrylate)s. The copolymers of M1 and monofunctional urethane methacrylate derived from 2‐hydroxyethyl methacrylate and phenyl isocyanate (M2) exhibited a linear rise of the Tg values depending on the composition ratio of M1. The NMR analysis and the estimation of monomer reactivity ratio and Q–e values suggested that the improvement of glass transition temperature resulted from a stereoregularity, meaning a syndiotacticity of the copolymers improved with increasing the composition ratio of M1. Furthermore, the thermal curing reaction of M1 or M2 with bifunctional urethane acrylate successfully proceeded, then the Tg value of the cured product from M1 was much higher than that from M2.
Comparison of open‐source three‐dimensional reconstruction pipelines for maize‐root phenotyping
Authors: Liu Suxing , Bonelli Wesley Paul , Pietrzyk Peter , Bucksch Alexander 
Published: May 2023

AbstractUnderstanding three‐dimensional (3D) root traits is essential to improve water uptake, increase nitrogen capture, and raise carbon sequestration from the atmosphere. However, quantifying 3D root traits by reconstructing 3D root models for deeper field‐grown roots remains a challenge due to the unknown tradeoff between 3D root‐model quality and 3D root‐trait accuracy. Therefore, we performed two computational experiments. We first compared the 3D model quality generated by five state‐of‐the‐art open‐source 3D model reconstruction pipelines on 12 contrasting genotypes of field‐grown maize roots. These pipelines included COLMAP, COLMAP+PMVS (Patch‐based Multi‐View Stereo), VisualSFM, Meshroom, and OpenMVG+MVE (Multi‐View Environment). The COLMAP pipeline achieved the best performance regarding 3D model quality versus computational time and image number needed. In the second test, we compared the accuracy of 3D root‐trait measurement generated by the Digital Imaging of Root Traits 3D pipeline (DIRT/3D) using COLMAP‐based 3D reconstruction with our current DIRT/3D pipeline that uses a VisualSFM‐based 3D reconstruction on the same dataset of 12 genotypes, with 5–10 replicates per genotype. The results revealed that (1) the average number of images needed to build a denser 3D model was reduced from 3000 to 3600 (DIRT/3D [VisualSFM‐based 3D reconstruction]) to around 360 for computational test 1, and around 600 for computational test 2 (DIRT/3D [COLMAP‐based 3D reconstruction]); (2) denser 3D models helped improve the accuracy of the 3D root‐trait measurement; (3) reducing the number of images can help resolve data storage problems. The updated DIRT/3D (COLMAP‐based 3D reconstruction) pipeline enables quicker image collection without compromising the accuracy of 3D root‐trait measurements.
Microfluidic Device for the Manipulation of Microparticles for Flow Cytometry Application
Authors: Attard Matthew , Coral David , Pedrol Èric , Aguiló Magdalena , Díaz Francesc , Mateos Xavier 
Published: May 2023

AbstractThis work produces a unique microfluidic device that acts as a “lab on a chip,” conducting separation, mixing, and concentration of microparticles similar to that required by cell sorting flow cytometry applications. The passive two‐dimensional device shows to be successful at separating polystyrene (PS) beads between 5 and 20 µm in diameter, mixing them with an external media, and concentrating them by 250% continuously with minimal sample preparation, while still being inexpensive, and effective. By implementing the microfluidic device, the processing steps are done within seconds due to its high throughput of 2 mL min−1, wherein different hydrodynamic phenomena such as Dean's forces, inertial lift forces, and enhanced diffusion are taken advantage of.
Theoretical study of the void collapse and shear band formation mechanism for β‐HMX
Authors: Long Yao , Chen Jun 
Published: May 2023

AbstractBased on molecular dynamics simulation, we obtain a shear band formation mechanism for β‐HMX. The shock wave reflected at void face induces rarefaction wave, and the velocity difference between rarefaction wave zone and shock wave zone induces slipping. A set of physical models are developed to describe the wave reflection, shear band expansion and energy dissipation. The orientation angle, face indices, expansion velocity and formation energy of shear bands are calculated. A complete physical picture for shear band formation is obtained.
Transformational leadership vs. proactive personality: Contributing factors to physiotherapists proactive behaviors and burnout during the SARS‐COV‐2 pandemic
Authors: Myaskovetsky Vadim , Shmueli Liora 
Published: May 2023

AbstractBackgroundIn May 2019, the World Health Organization (WHO) added burn out to the list of occupational phenomena in the 11th Revision of the International Classification of Diseases (ICD‐11). Soon thereafter, in March 2020, a global pandemic of SARS‐COV‐2 was declared.ObjectiveTo investigate the interplay between transformational leadership, a proactive personality, employee proactive behaviors, and burn out in the field of physiotherapy during the SARS‐COV‐2 pandemic.MethodsPhysiotherapists working at the Meuhedet Health Maintenance Organization (HMO) were asked to fill an online cross‐sectional survey, in which they were asked to evaluate the transformational behavior of their manager and to assess their own burn out rate, degree of self‐efficacy, proactive personality, and proactive behaviors. Eighty‐one physical therapists (average age of 37.3 years (SD = 9.0)) responded to the survey, most of whom were female (67.9%, n = 55).ResultsTransformational leadership and proactive personality were negatively associated with occupational burn out (β = −0.231, p < 0.05, β = −0.243, p < 0.05, respectively) among physiotherapists. The effect of the interaction between transformational leadership and proactive personality on proactive behaviors at work was not significant. However, a strong, significant positive relationship was found between proactive personality and proactive behaviors (β = 0.425, p < 0.001), and between self‐efficacy and proactive behaviors (β = 0.479, p < 0.001).ConclusionsThis up‐to‐date survey of transformational leadership and proactive personality among physiotherapists highlights these traits' important impact on burn out and proactive behaviors during the SARS‐COV‐2 pandemic. Furthermore, the transformational manager plays an important role in reducing burnout levels among physiotherapists, especially during a crisis such as the SARS‐COV‐2 pandemic.
Discovery of novel glucosinolates inhibiting advanced glycation end products: Virtual screening and molecular dynamic simulation
Authors: Cao Lan , Wang Yueyang , Chen Xin'an , Deng Fanyu , Li Zongchang , Wang Maosheng , Zhang Yiqing , Su Rui , Kim Chan Kyung 
Published: May 2023

AbstractProtein glycation can result in the formation of advanced glycation end products (AGEs), which pose a potential health risk due to their association with diabetic complications. Natural products are a source of drugs discovery and the search for potential natural inhibitors of AGEs is of great significance. Glucosinolates (GSLs) mainly from cruciferous plants have potential antioxidant, anti‐inflammatory, and anti‐glycation activities. In this study, the inhibitory activity of GSLs on bovine serum albumin (BSA) along with its mechanism was investigated by virtual screening and various computational simulation techniques. Virtual screening revealed that 174 GSLs were screened using Maestro based on the glide score and 89% of the compounds were found to have potential anti‐glycation ability with the docking scores less than −5 kcal/mol. Molecular docking showed that the top 10 GSLs were bound to the IIA structural domain of BSA. Among them, glucohesperin (1) and 2‐hydroxyethyl glucosinolate (2) had the lowest docking scores of −9.428 and −9.333 kcal/mol, respectively, reflecting their good binding affinity. Molecular dynamics simulations of 1 (ΔG = −43.46 kcal/mol) and 2 (ΔG = −43.71 kcal/mol) revealed that the complexes of these two compounds with proteins had good stability. Further binding site analysis suggested that the mechanism of inhibition of protein glycation by these two active ingredients might be through competitive hydrogen bonding to maintain the structural integrity of the protein, thus inhibiting glycation reaction. Moreover, the ADMET values and CYP450 metabolism prediction data were within the recommended values. Therefore, it can be concluded that 1 and 2 may act as potential anti‐glycation agents.
Residue behavior and efficacy of benzothiazole in grains under different fumigation conditions
Authors: Cui Kaidi , Zhou Lin , Jiang Chaofan , Yang Song , Zou Nan , Liu Feng , He Leiming , Mu Wei 
Published: May 2023

AbstractBackgroundBenzothiazole is a potential grain fumigant for Tribolium castaneum. However, its safety profile and suitable fumigation conditions remain unknown. We therefore investigated the insecticidal efficacy, accumulation and dissipation of benzothiazole in grains (wheat, corn and rice) under different temperatures.ResultsWe established a universal detection method (modified QuEChERS coupled with GC–MS/MS) of benzothiazole residues in three grains, which provided high linearity (R2 > 0.999), sensitivity (limits of detection = 0.001 mg/kg, limits of quantification = 0.002–0.005 mg/kg), accuracy (recoveries = 88.18–118.75%) and precision (relative standard deviations < 4.78%). The insecticidal efficacy order of benzothiazole was 30 ≥ 10 > 20 °C and corn > wheat > rice. Temperature positively affected the accumulation/dissipation rate of benzothiazole. Rice was the most easily accumulated and dissipated grain for benzothiazole residues, while corn accumulated benzothiazole more than wheat but less than rice, with dissipation slower than wheat and rice.ConclusionOur results provide important references for the application of benzothiazole and other fumigants. © 2023 Society of Chemical Industry.