bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardization of radiograph readings during bowel management week
Authors: Bischoff Andrea , Hayes Kari , Guimaraes Carolina , Merritt Anne , Wickham Maura , Schneider Lauren , Martin Hannah , Ketzer Jill , Rodriguez Victor , Peña Alberto , Torre Luis de La 
Published: July 2023

Abstract
Introduction: During "bowel management week," abdominal radiographs are used to monitor the amount and location of stool. A radiologist familiar with the treatment plan can provide an improved interpretation. The goal of this paper is to standardize the radiological reports during a bowel management week.
Methods: We saw 744 patients during bowel management week from May 2016 until March 2023. Diagnosis included: anorectal malformation (397), idiopathic constipation (180), Hirschsprung disease (89), and spina bifida (78). Laxatives were the treatment for 51% of patients, and 49% received enemas. Characteristic radiographs were selected for each treatment group for a proposed reading standardization.
Results: When the stool is visualized, it is crucial to report its location. Having a contrast enema helps with the correct interpretation of the colonic anatomy. It is also essential to always compare the amount of stool with the radiograph from the previous day to determine if there is an increase or decrease in stool. Examples of radiographs are shown to guide the use of the preferred proposed terminology.
Conclusion: Providing information regarding which treatment modality the patient is receiving and stating that a patient is on a bowel management week treatment is crucial for the radiologist to provide adequate interpretation. The radiologist must be familiar with the treatment goals and purpose of the daily radiograph.
Acute phase protein profile of sheep post-laparoscopy
Authors: de Gouvêa Liana Villela , Leite Thiago Ravache Sobreira , Nascimento Paulo Roberto Loureiro do , Teixeira André Luís Souza , Silva Paulo César do Amaral Ribeiro da , Filho José Aurelino Damasceno Ferreira , Helayel Michel José Sales Abdalla , Bento Lucas Drumond , de Alencar Nayro Xavier , Silva Pedro Leme , Fonseca Leandro Abreu da , Lessa Daniel Augusto Barroso 
Published: July 2023

Abstract
This study aims to evaluate the acute phase response (APR) of sheep submitted to different intraabdominal pressure (IAP) during laparoscopy, with no other invasive procedure, since the ovine model is also of particular interest for studies in humans. Ten healthy nonpregnant adult Santa Ines ewes were randomly submitted to a crossover study using different IAPs: 0 mmHg (G1), 10 mmHg (G2), 12 mmHg (G3), and 15 mmHg (G4). They were anesthetized and mechanically ventilated (VT=15 ml.kg−1) with positive end-expiratory pressure (3 cmH2O) and FiO2=1.0. The targeted acute phase proteins (APP) were albumin (Alb), transferrin (Tf), apolipoprotein A1 (Apo A1), haptoglobin (Hp), ceruloplasmin (Cp), α1 acid glycoprotein (α1-AGP) and α1 antitrypsin (α1-ATT), measured before (T0), 24h (T1), 72h (T2), 7 days (T3) and 14 days (T4) after the procedure, with their respective percentage change calculated. Statistical analysis consisted of two-way ANOVA for repeated measures followed by Holm-Šídák for multiple comparisons. In G4, Alb and Tf decreased at T3 and T4. Apo A1 decreased in all groups except in G4. Hp, Cp, and α1-AGP presented a similar behavior, however, Cp had the highest percentage change at T3 and T4. In G4, α1-ATT decreased at T3 and T4, but increased in all other groups. Albumin, ceruloplasmin and haptoglobin concentrations and percentage change best characterized the dynamics of the APR in this experimental model. More obvious changes were observed with the highest IAP (15 mmHg) than in other groups at 7- and 14-days post-laparoscopy, and postoperative care longer than this is advised.
Silencing lncRNA MALAT1 can promote autophagy and migration of C28/I2 chondrocytes induced by nitroprusside
Authors: Chen Kai , Cong Junzi , Tang Li , Li Ronghui , Zhang Yanhui , Sun Li , Zhang Li , Li Xinying , Jin Hong 
Published: July 2023

Abstract
Objective: To explore the effect of metastasis-associated lung adenocarcinoma transcript (MALAT1) on the autophagy, migration ability and cell survival rate of C28/I2 chondrocytes induced by sodium nitroprusside (SNP).
Methods: C28/I2 chondrocytes were treated with 0 mM, 0.5 mM, 0.75 mM, and 1 mM SNP for 12 h; si-MALAT1 was introduced into C28/I2 chondrocytes by lipofection technology followed by treatment and SNP for 12 h. The cell survival rate was measured using the CCK-8 method ,and cell migration was observed through cell scratch assays.The expression levels of autophagy-related proteins was measured using western blotting.The expression level of the MALAT1 gene was verified through qRT-PCR experiments. The effects of different concentrations of SNP on autophagy in C28/I2 chondrocytes were observed using mono-dansyl cadaverine (montane sulfonyl cadaverine, MDC) staining under a fluorescence microscope.
Results: The results showed that the expression level of Beclin-1andATG5, cell migration rate, and cell survival rate all decreased significantly,The lowest expression level was observed in cells cultured with 1 mM SNP concentration; The formation of autophagosomes was minimal when cells were cultured at 1 mM SNP concentration by fluorescence microscopy. The expression level of the MALAT1 gene was significantly increased in C28/I2 chondrocytes treated with 1 mM SNP for 12 h. Silencing MALAT1 led to up-regulation of the expression levels of two autophagy-related proteins, ATG5 and Beclin-1 in C28/I2 chondrocytes induced by SNP, resulting in increased cell migration and cell survival.
Conclusion: SNP can inhibit the autophagy, cell migration ability and survival rate of C28/I2 chondrocytes. MALAT1 plays an important role in developing osteoarthritis (OA) by affecting SNP-induced autophagy, migration ability, and cell survival rate in C28/I2 chondrocytes. Therefore, MALAT1 could be a potential target for osteoarthritis treatment.
A Mini-batch Stochastic Recursive Gradient Method with Barzilai-Borwein Step-Size for Machine Learning
Authors: Yang Yi-Ming , Wang Fu-Sheng , Peng Zheng , Zhou Xiao-Jun 
Published: July 2023

Abstract
As a mini-batch version of the SARAH algorithm, the MB-SARAH algorithm has received extensive attention due to its simple recursive scheme for updating stochastic gradient estimates. In this paper, we give a modification of the MB-SARAH method via cooperating with the BB step-size, shorted to MB-SARAH-BB. The MB-SARAH-BB combines some advantages of both MB-SARAH and BB methods, providing robustness in selecting initial step size during the optimization process. In the framework of MB-SARAH-BB, we propose a novel implementable method, Ada-MB-SARAH-BB, which utilizes adaptive probability for sampling in the mini-batch stochastic recursive gradient computation during the inner loop iteration. We establish the linear convergence of the MB-SARAH-BB and Ada-MB-SARAH-BB methods under some mild assumptions. Numerical experiments on standard machine learning datasets demonstrate that, the MB-SARAH-BB is effective and more competitive than the recent successful stochastic gradient methods. In addition, numerical experiments also demonstrate that the performance of Ada-MB-SARAH-BB is generally better than or comparable to MB-SARAH-BB method.
MSC Classification: 90C15 · 90C25 · 90C30
Clustering Analysis of Risk Factors for Non-suicidal Self-injury (NSSI) Behaviors in Adolescents：A cross-sectional study of western China
Authors: Hou Xin , Zhong Yunling , Zhao Jiayu , Luo Jing , He Jinglong , Kang Qian , Liu lingjiang , Li Xuehua , Yu Ling , Peng Zhenglei , Tang Lei , Yong Na , Luo Jiaming 
Published: July 2023

Abstract

Background and objectives: The analysis of clustering characteristics of disease risk factors makes for the formulation of corresponding prevention and control policies, but the risk factors for non-suicidal self-injury (NSSI) behaviors in adolescents is not covered, so this study is intended to explore the clustering characteristics of risk factors for NSSI behaviors in adolescents in the multi-center primary and secondary schools in western China.
Methods: Utilizing stratified and cluster sampling methods, a total of 13,784 primary and secondary school students who met the research standards were randomly selected as the survey subjects from January 2020 to January 2021, and the clustering situation of the seven risk factors (depression, anxiety, stress, low social support, tolerance, avoidance, and emotional venting) among the students was analyzed. The characteristics of the respondents with a high clustering degree of risk factors for NSSI behaviors were also identified with the hierarchical logistic regression analysis.
Results: 4.2% of the adolescents in western China were detected with NSSI behaviors in the past year; the risk factors were grouped into 4 clusters, ranging from level 0 to level 3, with each level including 7692 (55.8%), 3847 (27.9 %), 1303 (9.5%) and 941 (6.8%) of the survey subjects, respectively. The results of the Cochran-Armitage trend test analysis showed that there existed a linear trend between the clustering degree of risk factors and the detection rate of NSSI behaviors (P<0.000); according to the hierarchical Logistic regression analysis, the clustering degree of risk factors for NSSI behaviors was higher in the adolescents whose parents divorced and remarried 1.21（0.016~0.373）and whose fathers received only primary school education or below 1.23（0.005~0.404）. By contrast, the degree was lower in the adolescents who are male 0.93（-0.132~-0.003） and had never attended boarding school 0.83（-0.286~-0.096）, whose parents were not divorced 0.80（-0.367~-0.072）, and whose fathers were farmers 0.87（-0.271~0.006）.
Conclusion: The risk factors for NSSI behaviors in adolescents are in clusters. As the risk factors continue to cluster, NSSI behaviors can be detected more easily in adolescents. With respect to the endeavors to prevent and control NSSI behaviors in adolescents, more attention should be focused on the mental health of the adolescents who are female and attend boarding schools, whose parents have broken marriages, and whose fathers have low literacy.
Bifurcation analysis and chaos for a double-strains HIV coinfection model with intracellular delays, saturated incidence and Logistic growth
Authors: Chen Wei , Zhang Long , Wang Ning , Teng Zhidong 
Published: July 2023

Abstract

In this paper, a class of virus-to-cell HIV model with intracellular delays, saturated incidence and Logistic growth is proposed to characterize the interaction between two types HIV strains, i.e., wild-type and drug-resistant strains. First, a series of threshold criteria on the locally and globally asymptotic stability of (infection-free, dominant, coexistence) equilibria are discussed based on the basic reproduction number $R_0$. Furthermore, a detailed Hopf bifurcation analysis is performed on the coexistence equilibrium using two delays as bifurcation parameters. We find that the Hopf bifurcations induced by double-strains are evidently different and more complicated than single strain, the former switches from stability (periodic branches) to un-stability (chaos) more frequent and earlier than the latter since double-strains would yield more pairs of imaginary roots in the characteristic equations. Meanwhile, the total viral load of double-strains would be higher than that of single-strain as well. The emergence of drug resistance imposes either negative or positive influences on the survival of wild-type strain, which would further facilitate the transmission of HIV.
Unleashing the Power of Consolidate Cloud Computing: Secure and Energy-Efficient Virtual Machines at Your Service
Authors: ahmad wasim , Ali Aitizaz , Tin Ting Tin 
Published: July 2023

Abstract
Cloud computing has revolutionized the way businesses and individuals store, process, and access their data. As the demand for cloud services continues to grow, the need for efficient and secure cloud computing systems becomes increasingly vital. This paper introduces the concept of consolidating cloud computing systems by utilizing secure and energy-efficient virtual machines. The consolidation of cloud computing systems involves the optimization of resources, such as servers and storage, to maximize efficiency and minimize costs. By consolidating virtual machines onto fewer physical servers, resource utilization can be improved, resulting in reduced energy consumption and increased cost savings. Additionally, the consolidation approach enhances the overall security of the cloud computing environment, as it enables better monitoring and control of virtual machine instances. To ensure the security of virtual machines, various techniques can be implemented, such as encryption, access control mechanisms, and intrusion detection systems. These measures protect sensitive data and prevent unauthorized access, mitigating potential risks and vulnerabilities associated with cloud computing systems. Energy efficiency is another critical aspect addressed in this paper. By optimizing resource allocation and workload distribution, energy consumption can be minimized, leading to reduced carbon footprint and operational costs. The proposed system aims to strike a balance between energy efficiency and performance, ensuring that cloud computing resources are utilized effectively without compromising user experience. Overall, this paper presents a comprehensive approach to consolidate cloud computing systems, integrating secure and energy-efficient virtual machines. The proposed system not only enhances the security and reliability of cloud services but also contributes to environmental sustainability. The results of this research demonstrate the potential of consolidating cloud computing systems to revolutionize the way cloud services are provisioned, offering businesses and individuals secure and energy-efficient solutions for their computing needs..
Pneumocystis jiroveci and cytomegalovirus infection in a pemphigus patient treated with rituximab: a case report and literature review
Authors: Yang Lin , Wu Minna , Zhang Yiying , Huang Xiaoyi , Xie Dongyuan , Yang Guilin , Liu Xiaodi 
Published: July 2023

Abstract
Background: Rituximab is gradually considered the first-line treatment for pemphigus patients, which may make patients susceptible to opportunistic infections. Pneumocystis jiroveci and cytomegalovirus (CMV), are opportunistic pathogens that have an important impact of morbidity and mortality in immunosuppressed patients.
Case presentation: Herein, we present a rare case of a pemphigus patient with pneumonia who was infected concurrently with Pneumocystis jiroveci and CMV. The patient complained of a fever, severe non-productive cough and dyspnea after receiving two infusion of rituximab and was diagnosed with Pneumocystis jiroveci pneumonia (PJP) and CMV infection. Furthermore, we have made a brief review to summarize the features of pemphigus patients with PJP.
Conclusion: To our knowledge, this is the first case report depicting a pemphigus patient who was diagnosed with PJP and concomitant pulmonary CMV infection after receiving rituximab. Although the incidence of Pneumocystis jiroveciinfection is low, it is necessary for clinicians to be awake to the possibility of PJP in pemphigus patients with symptoms of pneumonia.
The Brachial Plexus and The Anterior Scalene Muscle: A Bilaterally Different Variation and Its Clinical Significance
Authors: Yang Jiaye , Shen Ke , Fang Bojia , Jiang Yiyue , Luo Yiting 
Published: July 2023

Abstract
PURPOSE
Anatomical variations of the brachial plexus (BP) are revealed in clinical practice and affect the pathogenesis of certain illnesses, including thoracic outlet syndrome (TOS), brachial plexus block anesthesia, and brachial plexus injuries. While the possibility of BP variations is high, bilaterally different variations are rare.
METHODS
A variation of the BP was observed during dissection of a 49-year-old female cadaver. The body was placed in a supine position and the root of the neck was exposed after removing the skin, superficial fascia, sternocleidomastoid muscle, clavicle and omohyoid muscle in turn.
RESULTS
This report presents a case of a bilateral variation of the 5th cervical nerve (C5) and its relation to the anterior scalene muscle (ASM). The left 5th cervical nerve passes anterior to the left anterior scalene muscle, while the right 5th cervical nerve penetrates through the right anterior scalene muscle.
CONCLUSION
Herein, this case report, accompanied by photographs of an actual cadaver, can help clinicians understand TOS, optimize the brachial plexus block procedure, and manage BP injuries better.
Efficacy and Validity of the Elite HRV Smartphone Application During Slow-Paced Breathing
Authors: Vondrasek Joseph D. , Riemann Bryan L. , Grosicki Gregory J. , Flatt Andrew A. 
Published: July 2023

Abstract
Slow-paced breathing during heart rate variability biofeedback is used to augment cardiac-autonomic modulation. This practice has become widely available with the advent of cost-free smartphone applications such as Elite HRV. However, whether Elite HRV can effectively augment heart rate variability (HRV) and accurately measure HRV during its guided slow-paced breathing feature has not been determined. Therefore, 20 healthy young adults (13 M/8 F) completed a single-visit counterbalanced cross-over protocol involving 10 min each of supine spontaneous (SPONT) and paced (PACED; 6 breaths•min-1) breathing while RR intervals were simultaneously recorded via a Polar H10 paired with Elite HRV and criterion electrocardiography (ECG). HRV values automatically computed by Elite HRV were compared with ECG-derived values filtered and computed using standardized methodology. PACED significantly increased low frequency power (LF) for Elite HRV and ECG (Ps ≤ 0.003) and between-condition difference values for Elite HRV and ECG LF were very largely correlated (Lin’s concordance correlation = 0.73). However, absolute LF values differed, and inconsistent effects were observed for other HRV parameters. For validity, agreement between devices for mean RR was acceptable irrespective of condition (Ps ≥ 0.06, coefficient of variation ≤ 2.2%). Conversely, agreement weakened for time and frequency domain parameters during SPONT and was further weakened for each during PACED. Findings revealed that although slow-paced breathing via Elite HRV effectively increased LF HRV, it weakened agreement with the criterion for conventional HRV parameters (excluding mean RR) relative to spontaneous breathing.
Discovering rhythmicity of neuronal oscillations
Authors: Myrov Vladislav , Siebenhühner Felix , Juvonen Joonas J. , Arnulfo Gabriele , Palva Satu , Palva J. Matias 
Published: July 2023

Abstract
Neuronal oscillations are commonly analyzed with power spectral methods that quantify signal amplitude, but not rhythmicity or "oscillatoriness" per se. Here we introduce a new method, the phase-autocorrelation functon(pACF), for direct quantification of rhythmicity. We applied pACF to human intracerebral stereo-electroencephalography (SEEG) and magnetoencephalography (MEG) data to quantify rhythmicity and uncovered a spectrally and anatomically fine-grained cortical architecture of single- and multi-frequency neuronal oscillations. We also extended the pACF approach to measure "burstiness" of oscillatory processes and characterized regions with stable and bursty oscillations. We found that rhythmicity is double-dissociable from amplitude and constitutes a functionally relevant and dynamic characteristic of neuronal oscillations.
Synthesis, microstructure and fluorescence properties of (YSZ)x-(YTaO4)1-x ceramics powder prepared by chemical co-precipitation method
Authors: Wang Changzheng , Wang Lulu , Lang Zeyu , Yuan Quan 
Published: July 2023

Abstract

In this paper, the (YSZ)x-(YTaO4)1−x (x = 0, 0.1, 0.2, 0.3, 0.4, 0.5) fluorescence ceramic powder was synthesized by chemical co-precipitation method, and the influence of Zr4+ concentration on the structure, morphology and luminescence properties of ytantalum phosphor was studied. The results show that the prepared ceramic powder consists of M'-YTaO4 and YSZ, which shows pebble-like morphology. And the grain size was gradually refined with the increase of Zr4+ contents. At 385 nm excitation, (YSZ)x-(YTaO4)1−x emits bluish green fluorescence between 450 nm to 550 nm and decays as a bi-exponential function. The maximum luminous intensity and fluorescence life time increases firstly and then decreases as the Zr4+ content increases. The fluorescence life of (YSZ)0.3-(YTaO4)0.7 is nearly 3 times of pure YTaO4 at room temperature. The fluorescence lifetimes of (YSZ)0.3-(YTaO4)0.7 decays exponentially with the increasing of temperature, thus the temperature of (YSZ)0.3-(YTaO4)0.7 can be achieved by measuring the lifetime of TaO43−.
The Relative Balance of Ruminococcus and Clostridium Contributes to Gut Health in Chinese Children: A Cohort Study on Childhood Diarrhea and Constipation
Authors: Ren Yi , Mu Yu , Chen Binghan , Li Sisi , Fang Qinyi , Ren Jing , Zhang Zhiming , Zhang Lanying , Zhang Kejian , Li Sabrina , Liu Wei , Cui Yutao , Li Xu 
Published: July 2023

Abstract
Diarrhea and constipation are common health concerns during childhood, with an estimated prevalence of 3% to 9% worldwide. Although numerous studies have identified strong association between gut microbiota and digestive-related diseases in children, little is known about the gut microbiota that simultaneously affects both diarrhea and constipation or their potential regulatory mechanisms. Here, we conducted a cohort study on 618 individuals (66 with diarrhea and 138 with constipation) via 16S rRNA sequencing of stool. Compared with healthy individuals, the significant reduction (n = 66, Chao1, ACE, p < 0.05) in the microbial diversity was observed in children with diarrhea, while a marked increase was observed in those with constipation (n = 138, Chao1, ACE, Shannon, and Simpson, p < 0.05). Importantly, we firstly determined a reversed effect from Clostridium and Ruminococcus illustrating significant synergistic changes [Clostridium levels decreased in the constipation group (p < 0.001) and increased in the diarrhea group (p = 0.005), while Ruminococcus levels increased in the constipation group (p = 0.033) and decreased in the diarrhea group (p = 0.006)] in the disease phenotypes compared with healthy control. Pathway analysis revealed significant correlation between the membrane transport and endocrine system pathways and the levels of both Clostridium and Ruminococcus, suggesting a potential shared regulatory mechanism in the pathogenesis of both diseases. In summary, this study reveals, for the first time, two core microbiota that might affect the steady intestinal balance in children, which provides important references for the potential diagnosis and treatment of constipation and diarrhea.
IMPORTANCE Previous studies have explored the composition and structure of the gut microbiota in different disease states, but there has been little investigation on the potential pathogenic regulatory mechanisms and key microbial biomarkers for clinically similar or dissimilar diseases. This study compared the gut microbiota between children with diarrhea and healthy controls, as well as between children with constipation and healthy controls. We found that the impact of diarrhea and constipation on the gut diversity differed and that Clostridium and Ruminococcus were significantly associated with both diseases, suggesting their potential diagnostic value. Moreover, we identified two metabolic pathways, membrane transport and the endocrine system that were strongly correlated with both diseases indicating possible pathogenic mechanisms. These results provide a theoretical basis for the diagnosis and pathogenic mechanisms of childhood diarrhea and constipation.