bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of mutation on neurotoxicity reduction of new chimeric reteplase, a computational study
Authors: Mohammadi pour Pardis , Mahnam Karim , Taherzadeh Mahsa , Ahangarzadeh Shahrzad , Alibakhshi Abbas , Mohammadi Elmira 
Published: June 2023

Background and purpose:
Excitotoxicity in nerve cells is a type of neurotoxicity in which excessive stimulation of receptors (such as N-methyl-d-aspartate glutamate receptors (NMDAR)) leads to the influx of high-level calcium ions into cells and finally cell damage or death. This complication can occur after taking some of the plasminogen activators like tissue plasminogen activator and reteplase. The interaction of the kringle2 domain in such plasminogen activator with the amino-terminal domain (ATD) of the NR1 subunit of NMDAR finally leads to excitotoxicity. In this study, we assessed the interaction of two new chimeric reteplase, mutated in the kringle2 domain, with ATD and compared the interaction of wild-type reteplase with ATD, computationally.

Experimental approach:
Homology modeling, protein docking, molecular dynamic simulation, and molecular dynamics trajectory analysis were used for the assessment of this interaction.

Findings/Results:
The results of the free energy analysis between reteplase and ATD (wild reteplase: -2127.516 ± 0.0, M1-chr: -1761.510 ± 0.0, M2-chr: -521.908 ± 0.0) showed lower interaction of this chimeric reteplase with ATD compared to the wild type.

Conclusion and implications:
The decreased interaction between two chimeric reteplase and ATD of NR1 subunit in NMDAR which leads to lower neurotoxicity related to these drugs, can be the start of a way to conduct more tests and if the results confirm this feature, they can be considered potential drugs in acute ischemic stroke treatment.
Association between sleep patterns and early childhood caries in 3–4-year-old children: A cross-sectional study
Authors: GeethaPriya PR , Asokan Sharath , YogeshKumar TD , Elamathe M. 
Published: June 2023

ABSTRACT

Aim:
The aim of this study was to assess the sleep practices of children and their association with early childhood caries (ECC) at three different age periods.

Methodology:
A cross-sectional study was conducted to assess the sleep practices, feeding practices, and oral hygiene practices of children during nighttime from 0 to 2 years of age. A survey among 550 mothers of children aged 3–4 years with ECC (n = 275) and without ECC (n = 275) was conducted using a pretested and validated questionnaire. The three practices (sleep practices, feeding practices, and oral hygiene practices) of children at 0–3 months, 4–11 months, and 1–2 years of age were recorded and analyzed.

Results:
Risk factors associated with ECC at 0–3 months of age were gender (odds ratio [OR]: 0.59, 0.36–0.98), no previous dental visit (OR: 2.30, 1.15–4.59), bedtime (OR: 3.54, 2.01–6.25), and intentional feeding practice at night (OR: 1.83, 1.0–3.35). At 4–11 months of age, no previous dental visit (OR: 3.28, 1.66–6.49), mother’s education (OR: 0.42, 0.23–0.76), frequent night wakes (OR: 5.98, 1.89–19.21), and intentional feeding practice at night (OR: 111.09, 32.25–382.68) and, at 1–2 years of age, no previous dental visit (OR: 2.37, 1.45–3.88), intentional feeding practice at night (OR: 19.12, 9.09–40.21), and breastfeeding for more than 2 years (OR: 14.56, 7.17–29.56) were associated with ECC.

Conclusion:
Lack of previous dental visit and intentional feeding at night were the common risk factors associated with ECC in children.
Monitoring patient compliance to dental home care instructions with the mobile-based ecosystem
Authors: Pammi Thejokrishna , Jois Krishaay N 
Published: June 2023

ABSTRACT

Background:
Caries risk assessment and management from the cornerstone for successfully applying a minimum intervention dentistry philosophy in managing dental caries. Most applied work on caries prevention acknowledges the role of oral hygiene and dietary control strategies in reducing the prevalence and incidence of caries. What we need to address, however, is the necessity of initiating and sustaining behaviors that will ensure the implementation of strategies, that is “patient compliance.”

Aims and Objectives:
To present a novel method to monitor oral health-care behavior on a day-to-day basis and guide the parent-child team to set self-help goals. In addition, sustain them over time until the oral environment has positively changed and improved in caries risk status.

Methodology:
A mobile-based application and digital ecosystem have been developed to record daily data, motivate the user and present it as monthly and periodic graphic output. This supplements other caries risk assessment methods employed in recall follow-up to understand the changing oral environment.

Results and Conclusion:
Pilot trial results are promising and our mobile-based application seems to be definite adjuvant in improving and monitoring patient compliance.
Prevalence of white spot lesions in children up to 71 months of age in Gujarat state
Authors: Kashyap Priyanka R. , Kaur Manpreet , Mahadevan Ganesh 
Published: June 2023

ABSTRACT

Introduction:
The earliest sign of a new carious lesion is the appearance of chalky white spots on the surface of the tooth, indicating an area of demineralization of enamel. At this stage, the demineralization process can be reversed or arrested. This study aimed to determine the prevalence of white spot lesions (WSLs) among children up to 71 months in Gujarat state and to increase awareness among parents about its various preventive measures.

Materials and Methods:
Oral examination was done using the mouth mirror and tongue depressor. The prevalence of WSL was recorded using the International Caries Detection and Assessment System II coding and WSL index by Gorelick.

Results:
The overall prevalence of WSL was 31.8% (n = 2025) in Gujarat state. The parents of the participating children explained the various preventive measures to prevent decay followed by diet counseling and toothbrushing techniques.

Conclusion:
Knowledge of the actual prevalence of WSL will help in the implementation of appropriate and timely preventive measures required to decrease the incidence of early childhood caries in that region.
Results of intragastric balloon treatment and evaluation of patient satisfaction
Authors: Avci Enver , Ay Serden 
Published: June 2023

Introduction:
Endoscopic bariatric therapies are an alternative treatment method for patients who do not respond to diet, exercise and drug therapy or who are not yet candidates for surgery or who are suitable and hesitant to undergo surgery. In this study, we aimed to evaluate our intragastric balloon (IGB) treatment results and the satisfaction of the patients in the light of the literature.

Materials and Methods:
The study was conducted by retrospectively evaluating the patients who underwent IGB application in the gastroenterology and general surgery endoscopy units of our hospital.

Results:
Sixty-eight patients who had IGB for 6 months were evaluated. The mean weight given was 10 (0–25) kg and the mean body mass index (BMI) decrease was 3.6 (0–9) kg/m2. A statistically significant decrease was obtained between the initial weight and BMI of our patients and the weight and BMI at the end of the 6th month (P ≤ 0.0001). Thirty-five (51.5%) patients reported that they were satisfied with the procedure, while 33 (48.5) reported that they were not satisfied.

conclusion:
IGBs for the treatment of obesity are an attractive form of treatment because they provide minimally invasive, temporary and significant weight loss. Patients need to be repeatedly told that diet and lifestyle changes should be followed in the treatment of IGB. Thus, we believe that possible disappointments can be prevented.
Serum adiponectin level is positively associated with vascular reactivity index by digital thermal monitoring in patients with coronary artery disease
Authors: Hsiao Chien-Hao , Hsu Bang-Gee , Lu Chia-Wen , Wang Ji-Hung 
Published: June 2023

Objectives:
Adiponectin has anti-inflammatory and antiatherogenic effects and is important in the pathogenesis of cardiovascular diseases. In this cross-sectional study, our objective was to study the potential correlation between serum adiponectin levels and endothelial function in participants with coronary artery disease (CAD).

Materials and Methods:
We collected serum specimens from 125 fasting participants with CAD. The endothelial function was measured using the vascular reactivity index (VRI) determined by digital thermal monitoring, and VRI values of >2.0, 1.0–1.9, and <1.0 indicated good, intermediate, and poor vascular reactivity, respectively. A commercially available enzyme immunoassay kit was used to measure serum adiponectin levels.

Results:
The cohort included 55, 57, and 13 patients with good, intermediate, and poor vascular reactivity, respectively. Poor vascular reactivity was shown to be associated with older age, higher levels of serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), C-reactive protein, and lower levels of serum albumin and adiponectin. The linear regression analysis with multivariable forward stepwise approach revealed that age (β = −0.232), serum LDL-C (β = −0.264), and serum adiponectin (β = 0.574) were correlated with the VRI in CAD patients significantly.

Conclusion:
Fasting serum adiponectin levels were associated with good endothelial function determined using the VRI in patients with CAD.
Collaborative Procurement Practices in Public Organizations: A Review of Forms, Benefits and Challenges
Authors: Nkunda Richard Manase , Kazungu Isaac , Changalima Ismail Abdi 
Published: June 2023

This study reviewed forms, benefits, and challenges of collaborative procurement practice that could be applied in public organizations in developing countries like Tanzania. The study is exploratory and descriptive in nature under which a systematic literature review was conducted to examine the various forms, benefits, and challenges of collaborative procurement. In this approach, information was gathered from the existing body of literature on collaborative procurement and cooperative purchasing practices. Based on the main results, the study ascertained that piggy-backing groups, third-party groups, professional networks, and project groups are the main four forms of collaborative procurement practices that may be applicable in public organizations. Results suggested that organizations that engage in collaborative procurement practices enjoy several benefits, including minimum prices, low transaction costs, high-quality products, reduced workloads, and minimal supply risks. However, demand heterogeneity can complicate the procurement process, and inflexibility and control of collaborative procurement activities are major challenges for implementing collaborative procurement practices. Despite these challenges, the study concluded that collaborative procurement practices can be beneficial in public organizations in developing countries like Tanzania. The study recommends that collaborative members establish clear guidelines and agreements for collaborative procurement practices to ensure successful implementation.
Sanitation and Hygiene Practices in Northern Ghana: An Analysis of Household Health Risks
Authors: Osumanu Issaka Kanton , Amin Awzai Mohammed 
Published: June 2023

This study assessed household health risks in relation to sanitation and hygiene practices. A convergent parallel mixed method design, involving a survey of 200 household heads and two semi-structured interviews, was employed. The forward linear regression method was used to determine how sanitation and hygiene practices influence household health risks. From the results, age was the most considered criterion for using a homestead toilet facility. Income made the most significant contribution to change in the choice of toilet facility with a Beta Weight of 0.313 at a statistically significant level of p<0.00. Income was again identified to be the most statistically significant determining factor for access to sanitation and hygiene materials with 0.389 at a significant alpha level of p<0.00. The identified factors that define sanitation and hygiene practices cut across gender division of labour, age, occupation, housing type and residential location. Owing to the range of demographic, social and economic factors influencing the adoption of proper sanitation and hygiene practices, it is recommended that sanitation and hygiene improvement interventions should inculcate socio-demographic and economic concepts to reduce household health risks.
TASK-BASED LANGUAGE TEACHING IN VIETNAM: RESEARCH TRENDS, FINDINGS, AND IMPLICATIONS
Authors: Sang Huynh Truong , Loi Nguyen Van 
Published: May 2023

It is widely assumed that task-based language teaching (TBLT) has been effectively applied in EFL contexts. In Vietnam, abundant research has been implemented to examine its effects on English proficiency as well as to identify perceptions and attitudes of both teachers and learners towards using this approach in classroom contexts. This paper aims to synthesize trends in research on task-based language teaching in the context by reviewing results extracted from a corpus of 60 studies. Key aspects like effects, challenges, teacher/learner perceptions and attitudes were selected for analysis and synthesis. The results revealed that the research tended to focus more on production skills than receptive skills, and that the implementation of TBLT was reported to cause challenges for teachers, while learners tended to hold positive attitudes toward the approach. Based on the research findings, some lessons were drawn for pedagogy and future research. For successful TBLT implementation, it is suggested that teachers are informed of the effects, engaged in reflections and that exams should be shifted towards communicative competence assessment. Future research could increase sample size and treatment duration, and especially address the challenges teachers, as the main agent, encounter in implementation.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0023/a.php" alt="Hit counter" /></p>
THERMAL CONCEPTS AND PHENOMENA IN EARLY CHIDHOOD SCIENCE EDUCATION: A LITERATURE REVIEW
Authors: Ioannou Michalis , Kaliampos George , Fragkiadaki Glykeria , Pantidos Panagiotis , Ravanis Konstantinos 
Published: May 2023

In the current study, an attempt is made to bring together and synthesize research data on the way early childhood children approach thermal phenomena and concepts. In this pool of data, the mental representations of young children, the barriers to the conceptualization of these phenomena and the effectiveness of specialized teaching interventions are highlighted and discussed. Going through a series of empirical studies the paper focuses on critical aspects of thermal phenomena and concepts such as thermal conductivity in solid and liquid materials, expansion and contraction of metals, thermal insulation, use of a thermometer etc. A considerable part of these studies prominently deals with the changes in the state of materials and in particular water and the water cycle in the natural environment. The literature review presented here provides a detailed overview and a classification of these studies as well as highlights the need to foreground the systemic character of phenomena and the unifying character of the concepts when approaching or researching about thermal phenomena in early childhood educational settings.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0028/a.php" alt="Hit counter" /></p>
Exploratory analysis of citizen observations of hourly precipitation over Scandinavia
Authors: Lussana Cristian , Baietti Emma , Båserud Line , Nipen Thomas Nils , Seierstad Ivar Ambjørn 
Published: May 2023

Abstract. We present a comparison between Netatmo hourly precipitation amounts and observations of the same quantity from weather stations managed by national meteorological services, the latter used as reference values. The empirical distributions of the crowdsourced observations in the surroundings of reference stations are used to assess accuracy and precision of crowdsourced data. We found that reference values are typically within the distribution of the crowdsourced data. However, as the amount of precipitation increases, the spread of the crowdsourced distribution increases and the reference values are more and more frequently found towards the right tail of the distribution. These results indicate that accuracy and precision of crowdsourced data change as precipitation increases. We have studied the sensitivity of our results to the size of the neighbourhood chosen around the reference stations and we show that by aggregating the values over those neighbourhoods, crowdsourced data can be trusted in determining precipitation occurrence. We have assessed the variability of precipitation within small neighbourhoods (of radius 1, 3 and 5 km) and we provide estimates on the basis of the precipitation amounts. Our study quantifies the variability of hourly precipitation over small regions, of the size of the so-called “unresolved spatial scales” in limited area models, based on three years of data collected at several places in Scandinavia.
Biografías petrarquistas hispanas y modelos autoriales de poetas en el siglo XVI
Authors: Pérez Pedro Ruiz 
Published: May 2023

Abstract
In the sixteenth century, four Petrarch vitae appear in separate editions of the poet, as a preliminary accessus. These are added to a previous manuscript, a translation of an exempt biography from the mid-fifteenth century. With their variants, the five texts make up a “Petrarch paradigm” that serves as an authorial image model for Hispanic followers of the Canzoniere. Thirteen years after the last of these biographies, that of Salusque Lusitano, Herrera composed Garcilaso’s life to open his edition. The comparative study of the resulting images illuminates one of the vectors of change proposed by the Sevillian in the introduction of a cultist poetic whose previous step is the decentering operation of the Garcilasian model.
Hacia una poética del espacio en “Miré los muros de la patria mía”
Authors: Villegas Simón Andrés 
Published: May 2023

Abstract
This article offers a reinterpretation of Quevedo’s sonnet “Miré los muros de la patria mía” based on the analysis of the textual mechanisms used by the poet to configure a unique poetic space. Starting off from one of the most recent works on this poem, which proposes its interpretation as an example of the poetry of ruins, I will try to demonstrate that Quevedo’s sonnet could be read as well within an interpretive framework that privileges the poem’s phenomenological aspects. From this perspective, “Miré los muros de la patria mía” makes a distinctive poetic proposal: an itinerant and spatial experience which ultimately looks for the reader’s involvement.
O restaurador-conservador no âmbito da conservação e do restauro de obras de arte
Authors: Monteiro Ilda 
Published: May 2023

Este trabalho tem como objetivo o estudo na área da conservação e restauro das obras de arte, cujos fatores citados ao longo do trabalho estão associados à degradação e à deterioração que podem ser provocados por causas físicas e ambientais.
O objetivo principal do conservador funciona como modelo de avaliação na assistência a espaços museológicos e galerias com a implementação de soluções técnicas viáveis para a sua conservação e salvaguarda do património. O restaurador requer não só uma profissionalização e especialização, mas também uma interdisciplinaridade e capacidade de trabalho especializado em grupo pelos responsáveis conservadores. Este processo resulta da segurança e preservação das coleções com determinadas condições ambientais e a requisição de peritos e meios técnicos de avaliação.
UPAYA MENGEMBANGKAN KETERAMPILAN MEMBACA ANAK USIA 5-6 TAHUN MELALUI MEDIA GAMBAR DI RA AL MANSHURIAH
Authors: Mukhtar Mukhtar 
Published: June 2023

Tujuan penelitian ini yaitu untuk meningkatkan kemampuan membaca dini pada anak usia 5-6 tahun melalui media gambar di RA Al Manshuriah tahun pelajaran 2022/2023, adapun pertanyaan penelitian sehingga rumusan masalah dari penelitian ini adalah 1) Bagaimana cara meningkatkan kemampuan membaca dini anak usia 5-6 melalui media gambar di RA Al Manshuriah 2) Apa saja hambatan Meningkatkan Kemampuan Membaca Anak Usia 5-6 Tahun dengan menggunakan media gambar di RA Al Manshuriah tahun pelajaran 2022/2023. Untuk menjawab pertanyaan penelitian tersebut peneliti merancang penelitian dengan menggunakan jenis dan metode kualitatif, dari penelitian ini usia anak 5-6 tahun pada RA Al Manshuriah tahun pelajaran 2022/2023, untuk mengumpulkan data peneliti menggunakan tekhnik observasi, wawancara, dokumentasi, selanjutnya menggunakan analisis data. Hasil dari penelitian ini menunjukkan bahwa upaya meningkatkan kemampuan membaca dini dengan menggunakan media gambar pada RA Al Manshuriah tahun pelajaran 2022/2023 sudah tepat yaitu dengan metode belajar sambil bermain, hal ini dibuktikan dengan hasil skor anak pada observasi ke dua yaitu Dari hasil observasi kedua menunjukan bahwa anak yang tingkat kemampuan membaca terdapat 9 orang anak berkembang sesuai harapan (BSH) 62,5%. 5 orang anak mulai berkembang (MB) 31,25%, dan 1 orang anak yang belum berkembang (BB) 6,25% . sesuai dengan factor-faktor pendukung yaitu metode yang menantang dan merangsang serta kepedulian seorang guru terhadap anak, adapun hambatan-hambatan yang dihadapi yaitu rasa ketertarikan anak terhadap guru masih kurang, tidak ada sinergi guru dengan sekolah, kerjasama antara guru dengan orang tua anak masih belum maksimal, sebagai alternative dari hambatan-hambatan tersebut adalah guru menghadirkan model-model pembelajaran yang menantang peduli terhadap nuansa dalam pembelajaran, menunjukkan kepribadian yang positif dengan menanamkan nilai-nilai agama.
UMKM Indonesia Menuju Industri Halal Dan Go Digital Dalam Memasuki Pasar Global
Authors: Kusjuniati Kusjuniati 
Published: June 2023

Permasalahan utama yang dihadapi oleh UMKM adalah pertama tentang sertifikasi halal dimana pada tahun 2024 seluruh UMKM di Indonesia wajib memiliki sertifikat halal dan go digital dalam operasional usahanya. Tujuan penulisan ini untuk mengetahui jumlah UMKM yang telah memiliki sertifikasi halal dan telah go digital. Metodologi penulisan menggunakan pendekatan kualitatif. Melalui penelitian kualitatif ini dimungkinkan untuk diperoleh pemahaman tentang kenyataan melalui proses berpikir induktif. Pemerintah berharap Indonesia bangkit ekonominya dengan mendorong UMKM untuk memberikan keyakinan pada konsumen dalam negeri maupun luar negeri dalam memproduksi produk-produk halal yang diharapkan makin meningkat dan menjadi yang terbesar di dunia menembus pasar dunia. Tujuan pemberian sertifikasi halal pada produk-produk yang dihasilkan oleh UMKM adalah agar UMKM Indonesia bisa bersaing di pasar global. Digitalisasi memberikan peluang untuk mempertahankan kelangsungan UMKM, dengan membuka pasar baru. Bila UMKM sudah go digital maka akan memiliki daya saing yang tinggi untuk memasuki pasar global.