bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDENTS' PERSPECTIVE ON PREREQUISITE SUBJECTS TOWARD THEIR THESIS WRITING
Authors: El-Sulukiyyah Ana Ahsana , Pusparini Diah Anita 
Published: March 2023

This study investigates the students’ perspective on the prerequisite subjects toward their thesis writing. Some problems occurred when students doing their thesis. Those problems could be from their preparation and their comprehension of the prerequisite subjects. It is a descriptive qualitative study with open-ended questionnaire as the primary instruments to get the data. The subjects of this study were 31 students who were finishing their thesis. Results show that students are aware that prerequisite subjects are important to write their thesis, moreover the subject namely Thesis Writing Methodology. According to students’ opinion it was the prominent subject to know how to prepare and compose their thesis writing. The conclusion of this study is the prerequisite subject is important to prepare and help students finishing their thesis without any writing block.
Evaluation of land use/land cover datasets in hydrological modelling using the SWAT model
Authors: Alawi Sayed Amir , Özkul Sevinç 
Published: March 2023

AbstractLand use/land cover (LULC) is a key influencer for runoff generation and the estimation of evapotranspiration in the hydrology of watersheds. Therefore, it is essential to use accurate and reliable LULC data in hydrological modelling. Ground-based data deficiencies are a big challenge in most parts of developing countries and remote areas around the globe. The main objective of this research was to evaluate the accuracy of LULC data from two different sources in hydrological modelling using the soil and water assessment tool (SWAT). The first LULC data was prepared by the classification of Landsat 8 satellite imagery, and the second LULC data was extracted from the ESRI 2020 global LULC dataset. The study was conducted on the Kokcha Watershed, a mountainous basin partly covered by permanent snow and glaciers. The accuracy assessment was done based on a comparison between observed river discharge and simulated river flow, utilizing each LULC dataset separately. After calibration and validation of the models, the acquired result was approximately similar and slightly (5.5%) different. However, due to the higher resolution and easily accessible ESRI 2020 dataset, it is recommended to use ESRI 2020 in hydrological modelling using the SWAT model.
Projection of disaster-causing risk of extreme precipitation in the Yangtze River Basin based on CMIP6
Authors: Xu Chengyu , Yuan Canyu , Li Xianghu , Lin Yaling , Fan Hongxiang 
Published: March 2023

Abstract
Global warming will significantly affect the frequency and intensity of extreme precipitation and further affect the spatio-temporal pattern of disaster-causing risk of extreme precipitation. This study analyzes the spatio-temporal trends of extreme precipitation and projects its disaster-causing risk under different climate scenarios in the Yangtze River Basin from 2021 to 2100. The results indicate that the extreme precipitation in the Yangtze River Basin shows an increasing trend in the future. Annual precipitation (PRCPTOT) increases by 33.05–42.56% under five scenarios compared with the historical period. The future change in heavy precipitation (R95p) also shows a significant increase, but heavy rain days (R50) and 5-day maximum precipitation (RX5day) decrease. The disaster-causing risk of extreme precipitation in the Yangtze River Basin is mainly Levels III and IV, accounting for 57.23–65.99% of the total basin area. The area with Level V is mainly distributed in the Poyang Lake Basin and the lower main stream of the Yangtze River. Moreover, the changes in disaster-causing risk of extreme precipitation are mainly manifested in the decrease of areas with low risk (Levels I and II) and the increase of areas with medium risk (Levels III and IV) in different periods.
An optimal design method for low-impact development (LID) facilities based on the hydrodynamic model and genetic algorithm-assisted decision-making
Authors: Zhang Wenqing , Hou Jingming , Shen Tengfei , Zhang Ye , Li Donglai , Wang Jian , Zhang Jianqi 
Published: March 2023

Abstract
The construction of low-impact development (LID) facilities has become an effective means to control urban waterlogging, but there is still a lack of scientific methods to achieve its accurate and reasonable planning and design. In this work, a high-precision hydrodynamic model was used to evaluate the construction effect of each LID facility scheme, and the fitted functional relationship was used to describe the law between the LID facility construction area and the construction effect. Finally, a genetic algorithm was used to automatically optimize the best LID facility construction scheme. Applying this method to the actual urban LID facility planning and construction, the optimal solution law is that the construction effect of single and combined LID facilities increases with the increase of construction cost. In the same low-cost construction scheme, the construction effect of combined LID facilities will be lower than that of single LID facilities, but with the continuous increase of construction cost, the construction effect of combined LID facilities will eventually be better than that of single LID facilities. According to this method, the decision-maker can get the optimal LID facility construction scheme to meet the actual engineering needs
Hydraulic characterization of the Adamawa-Cameroon aquifer using inverse slope method
Authors: Asfahani Jamal , Aretouyap Zakari , George Nyakno 
Published: March 2023

AbstractFifty vertical electrical soundings were carried out in the Adamawa region of Cameroon. The interpretation was done using inverse slope method (ISM) and curve matching methods. The aim was to employ the applicability and suitability of the ISM in deciphering the vertical electrical sounding (VES) data for groundwater and hydrogeophysical purposes in the Pan-African aquifers. The ISM can be used to interpret VES data collected with any electrodes array. The results obtained by the ISM geo-electrical interpretation correlate/agree well with the available lithological logs used in constraining the interpretation. The resistivity values obtained through this method are in the range of 20–900 Ω m with a mean of 241 Ω m and a standard deviation of 228 Ω m. The aquifer thickness is in the range of 2–90 m, with an average of 33 m and a standard deviation of 21 m. Resistivity, thickness and depth of the Pan-African aquifer in the Adamawa region, Central Africa have been determined and characterized using both the ISM and an integrated protocol of interpolation technique. The ISM can therefore be recommended for the interpretation of VES measurements in the similar Pan-African context worldwide.
Experimental and numerical investigation of the trajectories of free and pressurized jets through storage dams
Authors: Taheri Aghdam Ali , Salmasi Farzin , Hossein Zadeh Dalir Ali , Abbaspour Akram , Abraham John 
Published: March 2023

Abstract
The purpose of this study is to investigate the trajectories of pressurized and free-falling jets and to determine their location downstream of the dam. The results show that the measured jet trajectory and the values extracted from the jet projectile equations are not the same. This discrepancy may be due to the effect of air resistance on flow; the existing jet trajectory equations do not incorporate air resistance. Projectile equations used for calculating the trajectory of falling jets have an average error of 21 and 26% for free-falling and pressurized jets, respectively. To minimize this discrepancy, the projectile equations were corrected. Also, the numerical simulation predicts the trajectories of the free and pressurized jets on average with a relative error (RE) of 25.5 and 23.5%, respectively, compared to the laboratory data. These errors can be caused by neglecting the effect of air resistance. In addition, it was found that by increasing the Froude number, the location of the falling jet impact moves further from the dam toe.
Applications of biochar in sulfate radical-based advanced oxidation processes for the removal of pharmaceuticals and personal care products
Authors: Badiger Sourabh M. , Nidheesh P. V. 
Published: March 2023

AbstractRecently, biochar (BC) has been increasingly used as a catalyst for the degradation of ‘emerging pollutants’ (EPs). Pharmaceuticals and personal care products (PPCPs), which come under ‘EPs’, can be harmful to the aquatic ecosystem despite being present in very low concentrations (ng/L–μg/L). Advanced oxidation processes (AOPs), which produce sulfate radical (SR-AOPs), show a great potential to degrade PPCPs effectively from wastewater. It is mainly due to the higher stability, long half-lives and better non-selectivity of SO4• - compared with AOPs with •OH generation. Furthermore, research focus is now given on AOPs coupled with BC-supported catalyst to enhance the degradation of PPCPs because of quicker generation of radicals (•OH, SO4•−) by the activation of persulfate (PS) and peroxymonosulfate (PMS). This article sheds light on the catalytic ability of BC after its physical and chemical modifications such as acid/alkali treatment and metal doping. The role of persistent free radicals (PFRs) in the BC for effective removal of PPCPs has been elaborated. Its potential applications in synthetic as well as real wastewater have also been discussed.
Diagnostic and Management Challenges of Rapid Lung Metastasis of
Gestational Trophoblastic Neoplasia after a Non-molar Pregnancy: A Case
Report
Authors: Chand Trilok , Dreier Norbert , Haq Urfan Ul , Hachem Fady , Kumar Vikram 
Published: March 2023

Background:
Pulmonary metastasis of pregnancy-related rare gestational trophoblastic disease is common, and a patient’s rapid clinical deterioration leads to a
poor prognosis.

Case Presentation:
We report a case of a non-pregnant woman with severe respiratory symptoms masquerading as pulmonary infection who was diagnosed with
pulmonary metastasis of the gestational trophoblastic disease.

Conclusion:
The timely diagnosis of pulmonary metastasis was the key aspect in the management of our case, and she survived and was discharged to home
after a long hospitalization course.
Oxidative versus Reductive Stress in Breast Cancer Development
and Cellular Mechanism of Alleviation: A Current Perspective with
Anti-breast Cancer Drug Resistance
Authors: Ray Suman Kumar , Jayashankar Erukkambattu , Kotnis Ashwin , Mukherjee Sukhes 
Published: March 2023

Abstract:
Redox homeostasis is essential for keeping our bodies healthy, but it also
helps breast cancer cells grow, stay alive, and resist treatment. Changes in the redox
balance and problems with redox signaling can make breast cancer cells grow and
spread and make them resistant to chemotherapy and radiation therapy. Reactive
oxygen species/reactive nitrogen species (ROS/RNS) generation and the oxidant defense
system are out of equilibrium, which causes oxidative stress. Many studies have
shown that oxidative stress can affect the start and spread of cancer by interfering with
redox (reduction-oxidation) signaling and damaging molecules. The oxidation of invariant
cysteine residues in FNIP1 is reversed by reductive stress, which is brought on
by protracted antioxidant signaling or mitochondrial inactivity. This permits
CUL2FEM1B to recognize its intended target. After the proteasome breaks down
FNIP1, mitochondrial function is restored to keep redox balance and cell integrity. Reductive
stress is caused by unchecked amplification of antioxidant signaling, and
changes in metabolic pathways are a big part of breast tumors' growth. Also, redox
reactions make pathways like PI3K, PKC, and protein kinases of the MAPK cascade
work better. Kinases and phosphatases control the phosphorylation status of transcription
factors like APE1/Ref-1, HIF-1, AP-1, Nrf2, NF-B, p53, FOXO, STAT, and -
catenin. Also, how well anti-breast cancer drugs, especially those that cause cytotoxicity
by making ROS, treat patients depends on how well the elements that support a
cell's redox environment work together. Even though chemotherapy aims to kill cancer
cells, which it does by making ROS, this can lead to drug resistance in the long run.
The development of novel therapeutic approaches for treating breast cancer will be
facilitated by a better understanding of the reductive stress and metabolic pathways in
tumor microenvironments.
Oxidative Coupling Assembly Induced Bio-engineered Quercetin
Microspheres for the Gastrosparing Delivery of Diclofenac Sodium
Authors: Sharma Vishal , Lal Gupta Girdhari , Sharma Manu 
Published: March 2023

Objective:
The study aimed to develop microspheres of quercetin by oxidative coupling assembly
and these microspheres were used to deliver diclofenac sodium without causing gastrotoxicity.

Methods:
The oxidative coupling assembly of quercetin was carried out in the presence of copper sulfate
to yield quercetin microspheres. The microsphere of quercetin was loaded with diclofenac sodium
(QP-Diclo). The carrageenan induced paw edema in rats was used for anti-inflammatory action was
studied by using and acetic acid-induced writhing in mice was used to study the analgesic potential of
the QP loaded microspheres. The ulcerogenecity and gastrotoxicity comparison was made between
diclofenac and QP-Diclo.

Results:
The oxidative coupling assembly of quercetin resulted in microspheres of 10-20 μm in size,
which were loaded with diclofenac sodium (QP-Diclo). The marked anti-inflammatory activity was
observed by QP-Diclo treatment using carrageenan induced paw edema (in rats) and better analgesic
activity than diclofenac sodium in mice. The administration of QP-Diclo significantly elevated the diminished
overall nitrite/nitrate extent and thiobarbituric acid reactive and significantly increased the
diminished superoxide dismutase activity in comparison to diclofenac sodium in gastric mucosa.

Conclusion:
The results suggested that dietary polyphenol quercetin can be converted to microspheres
by oxidative coupling assembly and can be used to deliver diclofenac sodium without causing gastrotoxicity.
Evaluation of Gum Arabic Double-layer Microneedle Patch Containing
Sumatriptan for Loading and Transdermal Delivery
Authors: Zhang Xiaoduo , Liu Weijun , Wang Wei , Pi Mingli , Huang Beibei , Wu Fanhong 
Published: March 2023

Background:
As episodes of acute migraine for migraineurs, a self-treatment that promptly
relieves headaches and eliminates the associated symptoms would be optimal. Based on the consideration,
a rapidly dissolving double-layer microneedles derived from natural acacia was developed.
Methods: Under the optimized reaction conditions that was screened out through orthogonal designing

Methods:
Under the optimized reaction conditions that was screened out through orthogonal designing
test, acacia (GA) was conducted on the ionic crosslinking, a prescribed amount of cross-linking composites
was applied to fabricate the double-layer microneedles loaded with sumatriptan at the tip. The mechanical
strength and dissolving capability of penetrating pigskin along with in vitro release were measured.
The component and content of the resulting compound were determined with FT-IR and thermal
analysis, and the bonding state of cross-linker was characterized using X-ray photoelectron spectroscopy.

Results:
Each needle from the constructed microneedles with the maximal drug loading consisted of the
crosslinking acacia of around 10.89 μg and the encapsulated sumatriptan of around 1.821 μg. Apart
from the excellent solubility, the formed microneedles possessed enough mechanical stiffness to penetrate
the multilayer parafilm. The histological section of the pigskin confirmed the insertion depth of the
microneedles could reach 300 ± 28 μm, and the needle bulk in the isolated pigskin could be totally dissolved
within 240 s. Franz diffusion study displayed that an almost entire release of the encapsulated
drug might be realized within 40 min. The coagulum created from crosslinking was composed of -COOof
glucuronic acid in the component of acacia and the added crosslinker to form a double coordination
bond, and the crosslinking percentage reached about 13%.

Conclusion:
The release amount of drug from 12 patches made of the prepared microneedles was comparable
to that of subcutaneous injection, providing a new possibility for migraine treatment.
Neutrophil Extracellular Traps in Cerebral Ischemia/Reperfusion Injury:
Friend and Foe
Authors: Luo Haoyue , Guo Hanjing , Zhou Yue , Fang Rui , Zhang Wenli , Mei Zhigang 
Published: March 2023

Abstract:
Cerebral ischemic injury, one of the leading causes of morbidity and mortality worldwide,
triggers various central nervous system (CNS) diseases, including acute ischemic stroke (AIS) and
chronic ischemia-induced Alzheimer's disease (AD). Currently, targeted therapies are urgently needed
to address neurological disorders caused by cerebral ischemia/reperfusion injury (CI/RI), and the
emergence of neutrophil extracellular traps (NETs) may be able to relieve the pressure. Neutrophils
are precursors to brain injury following ischemic stroke and exert complicated functions. NETs extracellularly
release reticular complexes of neutrophils, i.e., double-stranded DNA (dsDNA), histones,
and granulins. Paradoxically, NETs play a dual role, friend and foe, under different conditions, for example,
physiological circumstances, infection, neurodegeneration, and ischemia/reperfusion. Increasing
evidence indicates that NETs exert anti-inflammatory effects by degrading cytokines and chemokines
through protease at a relatively stable and moderate level under physiological conditions, while
excessive amounts of NETs release (NETosis) irritated by CI/RI exacerbate the inflammatory response
and aggravate thrombosis, disrupt the blood-brain barrier (BBB), and initiates sequential neuron injury
and tissue damage. This review provides a comprehensive overview of the machinery of NETs formation
and the role of an abnormal cascade of NETs in CI/RI, as well as other ischemia-induced neurological
diseases. Herein, we highlight the potential of NETs as a therapeutic target against ischemic
stroke that may inspire translational research and innovative clinical approaches.
Pre-clinical and Clinical Evidence Associated with Infertility in Men:
Future Aspects
Authors: Khan Mohammad Nezamuddin , Mallela Anusruthi , Nishanthi M.G. , Chandran Lakshmi , S. Ankul Singh 
Published: March 2023

Abstract:
Infertility in men is more than 50% of cases and the real cause of infertility cannot be
determined by various factors and lack of technology. Infertility in males is a rising health concern
across the globe affecting around 7 percent of the total male population in the world. Various risk
factors are associated with several diseases’ outcomes and those involved have been shown to cause
infertility with male background due to their prone habits. Assisted Reproductive Technology
(ART) has evolved so far as treatment options for infertility by manipulating sperm or egg for a
woman to conceive being the only hope of bearing a biological child. Ancient medical techniques
could be enhanced using augmented reality with additional metrics to include orientation, 3D location
of speculations, and proximity to adjacent structures. With image-guided surgery, the need to
integrate medical imaging with surgery has promoted the research for new visualization modalities
based on AR, as surgical guidance or tool for surgical planning/diagnosis. Moreover, AR has its
advantage in high-quality data curation which establishes the fact that both AI and AR can be associated
together and make it useful in the imaging of infertile men. At present, research focuses on
improving sperm retrieval and assisted conception methods and perhaps in the future less invasive
procedures like AI and AR may be an option that provide Insight into data curation and enhanced
intelligence in the Imaging of cells.
A Compendium of Bioavailability Enhancement via Niosome Technology
Authors: Sharma Sumit , Kumari Neha , Garg Deepika , Chauhan Samrat 
Published: March 2023

Background:
Bioavailability is the dissimilarity between the total amount of drug exposure
to a person and the actual dose received by his body. The difference in bioavailability between
formulations of a given drug can have clinical implications.

Method:
Poor aqueous solubility, inappropriate partition coefficient, high first-pass metabolism,
narrow absorption window, and acidic pH of the stomach are the main reasons behind the low
bioavailability of drugs. There are three substantial methods to vanquish these bioavailability issues,
namely pharmacokinetic, biological, and pharmaceutical approaches.

Results:
In the pharmacokinetic approach a drug molecule is improved by making alterations in its
chemical structure. In the biological approach, the course of administration of the drug is changed;
for example, if a drug has very less oral bioavailability, it can be injected as parenteral or some
other route if feasible. In the pharmaceutical approach to enhance bioavailability, the physiochemical
properties of the drug or formulation are modified. It is cost-effective, less time-consuming,
and the risk factor is also minimum. Co-solvency, particle size reduction, hydrotrophy, solid dispersion,
micellar solubilisation, complexation, and colloidal drug delivery systems are some of the
commonly used methods to enhance the dissolution profiles of drugs via the pharmaceutical approach.
Similar to liposomes, niosomes are also vesicular carrier systems but non-ionic surfactants
are used instead of phospholipids in their formulation, i.e., their bilayer is comprised of non-ionic
surfactants that encircle the aqueous compartment. The niosomes are presumed to raise the bioavailability
of poorly water-soluble drugs by increasing their uptake by the M cells present in Peyer's
patches of lymphatic tissues of the intestine.

Conclusion:
Niosomal technology has become an attractive method to overcome several limitations
due to its various merits like biodegradability, high stability, non-immunogenic nature, low
cost, and flexibility to incorporate lipophilic as well as hydrophilic drugs. The bioavailability of
many BCS class II and IV drugs has been successfully enhanced using niosomal technology, like
Griseofulvin, Paclitaxel, Candesartan Cilexetil, Carvedilol, Clarithromycin, Telmisartan, and
Glimepiride. Niosomal technology has also been exploited for brain targeting via nasal delivery for
many drugs like Nefopam, Pentamidine, Ondansetron HCl, and Bromocriptine mesylate. Based on
this data, it can be concluded that niosomal technology has increased importance in bioavailability
enhancement and improving the overall performance of molecules in vitro and in vivo. Thus, niosomal
technology holds tremendous potential for scale-up applications, overcoming the drawbacks
of conventional dosage forms.