bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis, Literature, and Legitimation
Authors: Gaedtke Andrew 
Published: August 2023

Abstract
This commentary responds to several patterns in the articles that constitute the special issue on “Diagnosing America” and underscores questions of legitimacy related to the history of psychiatric diagnoses. Clinical diagnosis often operates as a speech-act through which a patient’s distress is made recognizable and legitimated. However, diagnostic categories have long been plagued by questions of legitimacy from within and beyond the field of psychiatry. Despite attempts to resolve these controversies through successive editions of the Diagnostic and Statistical Manual of Mental Disorders (DSM), concerns about the validity and reliability of diagnostic categories persist. The stakes of such questions are significant. Diagnostic categories may not only describe but can also shape historically shifting expressions of mental illness and their treatments. Many works of contemporary literature have engaged in these debates by foregrounding the social, political, and phenomenological dimensions of mental illness that have often been absent from diagnostic and therapeutic procedures. Such works prompt fundamental questions about how and why certain categories of mental illness come to be recognized as real.
Discussions of the cultural and social dimensions of psychiatric diagnosis should include . . . questions of legitimacy—not of patients’ distress but of the nosological systems that purport to recognize forms of distress as real according to the historically prevailing ontology.
A participatory approach to designing and implementing an occupational health intervention for the nail salon community in the Greater Philadelphia region
Authors: Huỳnh Trân B , Nguyễn Dương T , Vũ Nga , Robinson Lucy , Trần Emily , Nguyễn Nancy , Carroll-Scott Amy , Burstyn Igor 
Published: August 2023

Abstract

Background
The nail salon industry in the US comprises mostly immigrant-owned, small mom-and-pop salons that employ primarily first-generation immigrant workers from Asia. Because of the cultural and language barriers, both owners and workers may not avail themselves of the occupational safety resources. We formed an academic-community partnership to co-design a feasibility study and multi-level occupational health intervention for Vietnamese-speaking salon owners, workers, and community-based organization.

Methods
The intervention for each salon included (i) 2-h in-person training covering chemical safety, infection control, musculoskeletal prevention, and workers’ rights for both the owners and their employees, (ii) a tailored recommendation report for the owner, and (iii) check-ins with the owner during the 3-month follow-up. Community partner was trained to deliver the in-language training with technical assistance from the research team. Baseline and post-intervention individual data about health symptoms and behaviors, as well as personal chemical exposures were collected and analyzed.

Results
A total of 44 participants from 12 consented salons enrolled in the study. One salon dropped out at follow-up due to change of ownership. Analysis of the differences between post-and pre-intervention showed a tendency toward reduction in some self-reported symptoms in the respiratory system, skin, and eyes, neurotoxicity score, as well as chemical exposures. We could not rule out seasonality as an explanation for these trends. Increase in self-efficacy in some areas was observed post-intervention.

Conclusions
Our study demonstrated a successful academic-community partnership to engage community members in the intervention study. While the intervention effects from this feasibility study should be interpreted with caution, our preliminary results indicated that our community-based intervention is a promising approach to reduce work-related exposures among Asian American nail salon workers.
Defining Ideal Pretarsal Rolls Through a Morphometric Analysis in Asians
Authors: Chi Yarong , Li Zhujun , Jin Lin , Chong Yuming , Huang Jiuzuo , Yu Nanze , Long Xiao 
Published: August 2023

Abstract

Background
Pretarsal rolls are a crucial aesthetic feature. Despite numerous studies conducted on periorbital aesthetics, there remains a dearth of research on the ideal pretarsal rolls.

Objectives
This study aimed to investigate 4 aesthetic characteristics of ideal pretarsal rolls: presence, width, proportion, and morphology.

Methods
Respondents (385, including 80 aesthetic specialists) were presented with 7 series of images of pretarsal rolls, including 2 series of pretarsal roll existence, 2 series of varying widths, 2 series of different ratios between pretarsal roll and palpebral fissure height, and 1 series about morphology. Participants were asked to rank each image within a given series from most attractive to least attractive. The rankings were then analyzed according to population demographics.

Results
The majority of respondents deemed images with pretarsal rolls to be more aesthetically pleasing (P &lt; .001) than those without such features. Additionally, pretarsal rolls with a width of 5 mm (P &lt; .001), a ratio to palpebral fissure height of 0.5:1 (P &lt; .001), and a crescent shape (P &lt; .001) were perceived as the most attractive. Moreover, individuals aged 40 or younger exhibited a significant preference for images with pretarsal rolls compared to older groups (P &lt; .001), and females displayed a greater inclination toward a medium ratio of pretarsal roll to palpebral fissure height than males did (0.5:1 P = .003, 0.618:1 P &lt; .001).

Conclusions
This study validates the optimal characteristics of pretarsal rolls, which provides insight into pretarsal roll aesthetics and holds significant implications for surgical planning and effect assessment in future periocular procedures involving pretarsal rolls.

Level of Evidence: 3
Both learning and syntax recognition are used by great tits when answering to mobbing calls
Authors: Salis Ambre , Léna Jean-Paul , Lengagne Thierry 
Published: August 2023

Abstract
Mobbing behavior, in addition to its complex cooperative aspects, is particularly suitable to study the mechanisms implicated in heterospecific communication. Indeed, various mechanisms ranging from pure learning to innate recognition have been proposed. One promising yet understudied mechanism could be syntax recognition, especially given the latest works published on syntax comprehension in birds. In this experiment, we test whether great tits use both learning and syntax recognition when responding to heterospecifics. In the first part of the experiment, we demonstrate that great tits show different responses to the same heterospecific calls depending on their sympatric status. In the second part, we explore the impact of reorganizing the notes of the heterospecific mobbing calls to fit the syntax of great tits. Great tits showed an increased mobbing response toward the heterospecific calls when they shared their own call organization. Our results corroborate the recent finding that syntactic rules in bird calls may have a strong impact on their communication systems and enlighten how various mechanisms can be used by the same species to respond to heterospecific calls.
iDeLUCS: a deep learning interactive tool for alignment-free clustering of DNA sequences
Authors: Millan Arias Pablo , Hill Kathleen A , Kari Lila 
Published: August 2023

Abstract

Summary
We present an interactive Deep Learning-based software tool for Unsupervised Clustering of DNA Sequences (iDeLUCS), that detects genomic signatures and uses them to cluster DNA sequences, without the need for sequence alignment or taxonomic identifiers. iDeLUCS is scalable and user-friendly: its graphical user interface, with support for hardware acceleration, allows the practitioner to fine-tune the different hyper-parameters involved in the training process without requiring extensive knowledge of deep learning. The performance of iDeLUCS was evaluated on a diverse set of datasets: several real genomic datasets from organisms in kingdoms Animalia, Protista, Fungi, Bacteria, and Archaea, three datasets of viral genomes, a dataset of simulated metagenomic reads from microbial genomes, and multiple datasets of synthetic DNA sequences. The performance of iDeLUCS was compared to that of two classical clustering algorithms (k-means++ and GMM) and two clustering algorithms specialized in DNA sequences (MeShClust v3.0 and DeLUCS), using both intrinsic cluster evaluation metrics and external evaluation metrics. In terms of unsupervised clustering accuracy, iDeLUCS outperforms the two classical algorithms by an average of ∼20%, and the two specialized algorithms by an average of ∼12%, on the datasets of real DNA sequences analyzed. Overall, our results indicate that iDeLUCS is a robust clustering method suitable for the clustering of large and diverse datasets of unlabeled DNA sequences.

Availability and implementation
iDeLUCS is available at https://github.com/Kari-Genomics-Lab/iDeLUCS under the terms of the MIT licence.
A retrospective cohort study of the efficacy of metronidazole in oral lichen planus
Authors: Hollis Alison N , Myers Emma L , Culton  Donna A 
Published: August 2023

Abstract
Lichen planus (LP) is an inflammatory dermatosis with mucosal variants, including oral LP (OLP). OLP has a relapsing chronic course and may significantly affect a patient’s quality of life. We analysed the efficacy of metronidazole as a treatment for OLP via a retrospective chart review of patients with a diagnosis of OLP seen at our institution over 10 years. Thirty patients with OLP were treated with metronidazole 500 mg twice daily. Most patients (n = 18; 60%) showed improvement with metronidazole, including 10 (33%) who experienced complete resolution of symptoms. Our results were limited by the retrospective nature of the review and the relatively small cohort size. Given the efficacy, mild side-effect profile and the less immunosuppressive nature of metronidazole vs. alternative systemic treatment options, metronidazole is a reasonable option to try in patients with symptomatic OLP who have failed topical treatment options.
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions
Authors: Devan Jan , Nosi Vladimir , Spagnuolo Julian , Chancellor Andrew , Beshirova Aisha , Loureiro Jose Pedro , Vacchini Alessandro , Hendrik Niess Jan , Calogero Raffaele , Mori Lucia , De Libero Gennaro , Hruz Petr 
Published: August 2023

AbstractCrohn’s disease (CD) is a chronic immune-mediated disorder of the gastrointestinal tract. Extensive screening studies have revealed the accumulation of immune cell subsets with unique plasticity and immunoregulatory properties in patients with CD. We performed phenotypic and functional studies on inflamed and non-inflamed bioptic tissue to investigate the presence of distinct T cells in the intestinal mucosa of CD patients. We analysed hundreds of surface molecules expressed on cells isolated from the intestinal tissue of CD patients using anti-CD45 mAbs-based barcoding. A gene ontology enrichment analysis showed that proteins that regulate the activation of T cells were the most enriched group. We, therefore, designed T-cell focused multicolour flow-cytometry panels and performed clustering analysis which revealed an accumulation of activated TEM CD4+CD39+ T cells producing IL-17 and IL-21 and increased frequency of terminally differentiated TCR Vδ1+ cells producing TNF-α and IFN-γ in inflamed tissue of CD patients. The different functional capacities of CD4+ and TCR Vδ1+ cells in CD lesions indicate their non-overlapping contribution to inflammation. The abnormally high number of terminally differentiated TCR Vδ1+ cells suggests that they are continuously activated in inflamed tissue, making them a potential target for novel therapies.
Shank3 mutations enhance early neural responses to deviant tones in dogs
Authors: Wu Liang , Mei Shuting , Yu Shan , Han Shihui , Zhang Yong Q 
Published: August 2023

AbstractBoth enhanced discrimination of low-level features of auditory stimuli and mutations of SHANK3 (a gene that encodes a synaptic scaffolding protein) have been identified in autism spectrum disorder patients. However, experimental evidence regarding whether SHANK3 mutations lead to enhanced neural processing of low-level features of auditory stimuli is lacking. The present study investigated this possibility by examining effects of Shank3 mutations on early neural processing of pitch (tone frequency) in dogs. We recorded electrocorticograms from wild-type and Shank3 mutant dogs using an oddball paradigm in which deviant tones of different frequencies or probabilities were presented along with other tones in a repetitive stream (standards). We found that, relative to wild-type dogs, Shank3 mutant dogs exhibited larger amplitudes of early neural responses to deviant tones and greater sensitivity to variations of deviant frequencies within 100 ms after tone onsets. In addition, the enhanced early neural responses to deviant tones in Shank3 mutant dogs were observed independently of the probability of deviant tones. Our findings highlight an essential functional role of Shank3 in modulations of early neural detection of novel sounds and offer new insights into the genetic basis of the atypical auditory information processing in autism patients.
Immunogenicity of High-Dose Versus MF59-Adjuvanted Versus Standard Influenza Vaccine in Solid Organ Transplant Recipients: The Swiss/Spanish Trial in Solid Organ Transplantation on Prevention of Influenza (STOP-FLU Trial)
Authors: Mombelli Matteo , Neofytos Dionysios , Huynh-Do Uyen , Sánchez-Céspedes Javier , Stampf Susanne , Golshayan Dela , Dahdal Suzan , Stirnimann Guido , Schnyder Aurelia , Garzoni Christian , Venzin Reto M , Magenta Lorenzo , Schönenberger Melanie , Walti Laura , Hirzel Cédric , Munting Aline , Dickenmann Michael , Koller Michael , Aubert John-David , Steiger Jürg , Pascual Manuel , Mueller Thomas F , Schuurmans Macé , Berger Christoph , Binet Isabelle , Villard Jean , Mueller Nicolas J , Egli Adrian , Cordero Elisa , van Delden Christian , Manuel Oriol 
Published: August 2023

Abstract

Background
The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so new vaccination strategies are needed in this population.

Methods
Adult SOT recipients from 9 transplant clinics in Switzerland and Spain were enrolled if they were &gt;3 months after transplantation. Patients were randomized (1:1:1) to a MF59-adjuvanted or a high-dose vaccine (intervention), or a standard vaccine (control), with stratification by organ and time from transplant. The primary outcome was vaccine response rate, defined as a ≥4-fold increase of hemagglutination-inhibition titers to at least 1 vaccine strain at 28 days postvaccination. Secondary outcomes included polymerase chain reaction–confirmed influenza and vaccine reactogenicity.

Results
A total of 619 patients were randomized, 616 received the assigned vaccines, and 598 had serum available for analysis of the primary endpoint (standard, n = 198; MF59-adjuvanted, n = 205; high-dose, n = 195 patients). Vaccine response rates were 42% (84/198) in the standard vaccine group, 60% (122/205) in the MF59-adjuvanted vaccine group, and 66% (129/195) in the high-dose vaccine group (difference in intervention vaccines vs standard vaccine, 0.20; 97.5% confidence interval [CI], .12–1); P &lt; .001; difference in high-dose vs standard vaccine, 0.24 [95% CI, .16–1]; P &lt; .001; difference in MF59-adjuvanted vs standard vaccine, 0.17 [97.5% CI, .08–1]; P &lt; .001). Influenza occurred in 6% of the standard, 5% in the MF59-adjuvanted, and 7% in the high-dose vaccine groups. Vaccine-related adverse events occurred more frequently in the intervention vaccine groups, but most of the events were mild.

Conclusions
In SOT recipients, use of an MF59-adjuvanted or a high-dose influenza vaccine was safe and resulted in a higher vaccine response rate.

Clinical Trials Registration
Clinicaltrials.gov NCT03699839.
The anaemia treatment journey of CKD patients: from epoetins to hypoxia-inducible factor-prolyl hydroxylase inhibitors
Authors: Locatelli Francesco , Del Vecchio Lucia , Elliott Steve 
Published: August 2023

ABSTRACT
The discovery and development of erythropoiesis-stimulating agents was a journey lasting more than a century, leading to the cloning and approval of recombinant human erythropoietin (rHuEpo). This was an impressive clinical advance, providing the possibility of correcting the symptoms associated with anaemia in chronic kidney disease. Associated iron use was needed to produce new haemoglobin-containing blood red cells. Partial anaemia correction became the standard of care since trials aiming for near-normal haemoglobin levels showed a higher risk of adverse cardiovascular events. Hoping to reduce the cardiovascular risks, a new category of drugs was developed and tested. Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are small molecules than can be formulated into orally active pills. They simulate reduced tissue oxygen pressure, thus stimulating the production of endogenous erythropoietin (Epo) by the kidneys and liver. Clinical trials with these compounds demonstrated that HIF-PHIs are at least as effective as rHuEpo in treating or correcting anaemia in non-dialysis and dialysis patients. Trials with HIF-PHIs did not demonstrate superiority in safety outcomes and in some trials, outcomes were worse. There was also a focus on oral delivery, a possible beneficial iron-sparing effect and the ability to overcome Epo resistance in inflamed patients. A negative effect is possible iron depletion, which may explain adverse outcomes.
Left atrial veno-arterial extracorporeal membrane oxygenation in post-myocardial infarction ventricular septal defect with cardiogenic shock: a case report
Authors: Jiménez-Rodríguez Gian Manuel , Rojas-Velasco Gustavo , Arias-Sánchez Eduardo A , Manzur-Sandoval Daniel , Vega-Servin Norman Said , Quirazco-Cordova Ricardo-Eduardo , Eid-Lidt Guering 
Published: August 2023

Abstract

Background
Ventricular septal defect (VSD) complicating acute myocardial infarction (MI) represents a life-threatening condition and has a mortality of &gt;90% if left untreated.

Case summary
A 53-year-old man with a prior medical history of diabetes and hypertension presented with cardiogenic shock secondary to VSD as a mechanical complication of non-reperfused inferior MI.

Discussion
The choice of mechanical support can be difficult in this type of patient. Given the risk of an increased shunt because of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and the increase in left ventricle (LV) afterload, several measures were taken to plan the best ECMO configuration. Given the absence of any real improvement in the LV and an elevated residual ratio between pulmonary and systemic flow (Qp/Qs), the final decision was to switch to left atrial VA-ECMO (LAVA-ECMO). The use of LAVA-ECMO improved the patient’s haemodynamics and allowed his condition to stabilize; LAVA-ECMO is feasible and may be effective as a mechanical circulatory support (MCS) strategy for patients in cardiogenic shock due to VSD as a mechanical complication of acute MI.
The impact of the COVID-19 pandemic on recovery from cardiac surgery over time: results of the CardiacCovid study from three UK national lockdowns
Authors: Sanders Julie , Beaumont Emma , Dodd Matthew , Murray Sarah E , Owens Gareth , Berry Alan , Hyde Edward , Bueser Teofila , Clayton Tim , Oo Aung Ye 
Published: August 2023

Abstract
This prospective study explores health-related quality of life (EQ-5D-5L), event-related distress (IES-R), and depression (CES-D) after cardiac surgery during three COVID-19 lockdowns imposed in the UK. Overall, 253 patients (Lockdown 1 n = 196; 2 n = 45; 3 n = 12) completed the above-mentioned questionnaires at baseline, 1 week after discharge, and 6 weeks and 6 and 12 months after surgery. While EQ-5D-5L values were similar across all cohorts, those who underwent surgery during Lockdowns 2 and 3 had higher IES-R scores at 1 year and higher IES-R and CES-D baseline scores, respectively. Generally, increased distress, worse depression, and poorer HRQoL were observed in women.
Registration ClinicalTrials.gov: NCT04366167
Mechanisms, predictors, and evolution of severe peri-device leaks with two different left atrial appendage occluders
Authors: Lakkireddy Dhanunjaya , Nielsen-Kudsk Jens Erik , Windecker Stephan , Thaler David , Price Matthew J , Gambhir Alok , Gupta Nigel , Koulogiannis Konstantinos , Marcoff Leo , Mediratta Anuj , Anderson Jordan A , Gage Ryan , Ellis Christopher R 
Published: August 2023

Abstract

Aims
Incomplete left atrial appendage occlusion (LAAO) due to peri-device leak (PDL) is a limitation of the therapy. The Amulet IDE trial is the largest randomized head-to-head trial comparing the Amulet and Watchman 2.5 LAAO devices with fundamentally different designs. The predictors and mechanistic factors impacting differences in PDLs within the Amulet IDE trial are assessed in the current analysis.

Methods and results
An independent core lab analysed all images for the presence or absence of severe PDL (&gt;5 mm). The incidence, mechanistic factors, predictors using propensity score-matched controls, and evolution of severe PDLs through 18 months were assessed. Of the 1878 patients randomized in the trial, the Amulet occluder had significantly fewer severe PDLs than the Watchman device at 45 days (1.1 vs. 3.2%, P &lt; 0.001) and 12 months (0.1 vs. 1.1%, P &lt; 0.001). Off-axis deployment or missed lobes were leading mechanistic PDL factors in each device group. Larger left atrial appendage (LAA) dimensions including orifice diameter, landing zone diameter, and depth predicted severe PDL with the Watchman device, with no significant anatomical limitations noted with the Amulet occluder. Procedural and device implant predictors were found with the Amulet occluder attributed to the learning curve with the device. A majority of Watchman device severe PDLs did not resolve over time through 18 months.

Conclusion
The dual-occlusive Amplatzer Amulet LAA occluder provided improved LAA closure compared with the Watchman 2.5 device. Predictors and temporal observations of severe PDLs were identified in the Amulet IDE trial.

Clinical trial registration
https://clinicaltrials.gov Unique identifier NCT02879448.