bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change will lead to a significant reduction in the global cultivation of Panicum milliaceum
Authors: Huang Yi , Yang Yang , Zeng Zhefe , Jiang Xue , Liu Mei , Yang Jingtian 
Published: April 2023

Abstract
Panicum milliaceum is a C4 crop with characteristics of drought resistance, infertility tolerance and wide adaptability. It is a specialty crop for maintaining agricultural stability in arid and infertile areas of the world. Predicting the potential global geographic distribution of Panicum milliaceum and clarifying its ecological requirements will help advance the development of agriculture, which is important for maintaining human health and solving the global food crisis. Based on 5637 global distribution records of Panicum milliaceum and environmental factor variables, this study predicted the potential global geographic distribution of Panicum milliaceum in the present and future using the Maxent model and ArcGIS software. The contribution of environmental factor variables was used to assess the constraints on the potential geographic distribution of Panicum milliaceum. The accuracy of the Maxent model predictions was evaluated by three assessments of AUC values, TSS values and kappa statistics. The results showed that the Maxent model predicted high accuracy, and the simulation results were credible. The current total suitable habitat area of Panicum milliaceum was 4563.82×104 km2, mainly distributed in UNITED STATES, BRAZIL, AUSTRALIA, CHINA, INDIA, RUSSIAN FEDERATION. The high suitable habitat area of Panicum milliaceum was 484.95×104 km2, accounting for 10.63% of the total suitable habitat area, mainly distributed in the UNITED STATES, RUSSIAN FEDERATION, FRANCE, UKRAINE, AUSTRALIA, GERMANY, etc. Soil factor (hswd)was the most important environmental factor limiting the potential geographic distribution of Panicum milliaceum, followed by precipitation factor (Precipitation of Driest Month, bio14) and temperature factor (Mean Temperature of Wettest Quarter, bio8). Under the four future climate change scenarios, the area of the potential geographic distribution of Panicum milliaceum decreases to different extents at different levels compared to the contemporary period. Therefore, climate change may significantly affect the global distribution pattern of Panicum milliaceum cultivation in the future, and thus reshape the global Panicum milliaceum production and trade patterns.
Pairing-based Accountable Subgroup Multi-signatures with Verifiable Group Setup
Authors: Ağırtaş Ahmet Ramazan , Yayla Oğuz 
Published: April 2023

Abstract
An accountable subgroup multi-signature is a kind of multi-signature scheme in which any subgroup S of a group G of potential signers jointly sign a message m, ensuring that each member of S is accountable for the resulting signature. In this paper, we propose three novel pairing-based accountable subgroup multi-signature (ASM) schemes, which are secure against existential forgery under chosen-message attacks and computational co-Diffie-Hellman assumption. In the first one, we use Feldman’s verifiable secret sharing scheme as an implicit authentication and proof-of-possession for setting up group G. In the second one, the members participating in authentication are decided by the subgroup. In the third one, we consider a designated combiner managing the authentication process. All schemes we propose here require fewer computations in the signature generation, signature aggregation, and verification phases than the pairing-based ASM scheme proposed by Boneh, Drijvers and Neven. Moreover, our first and third ones solve the open problem of constructing an ASM scheme in which the subgroup S of signers is unknown before the signature generation. Besides, we give a method of eliminating the combiner in case of knowing the subgroup of signers S in advance. Further, we extend our proposed schemes to aggregated versions. For N accountable subgroup multi-signatures, aggregated versions of our proposed schemes output an aggregated signature with the size of a single group (G1 ) element and require N + 1 pairings in aggregated signature verification. In contrast, the partially aggregated ASM scheme of Boneh, Drijvers and Neven gives an aggregated signature with the size of N + 1 group elements and requires 2N + 1 pairings in aggregated signature verification.
Comorbidities contributing to high-cost hospital care for patients with COPD exacerbation
Authors: Wang Mingdie , Wang Fengyan , Shi Jingrong , Zhang Dongying , Jian Wenhua , Chen Yijun , Feng Jieyu , Zheng Jinping , Liang Zhenyu 
Published: April 2023

Abstract
Objective Although comorbidities are prevalent in chronic obstructive pulmonary disease (COPD) patients, little is known about the impact of comorbidities on hospitalization costs for COPD in Chinese hospitals. This study aimed to evaluate the impact of comorbidities on hospital costs in patients with COPD.Methods We conducted a real-world, retrospective, observational study. Patients with the major discharge diagnosis of COPD at the First Affiliated Hospital of Guangzhou Medical University between December 2013 and December 2020 were enrolled. Demographic and clinical parameters were sourced from hospital data and medical records. The top 20% of patients by cost were included in the high-cost group. Univariate and multivariate analyses were used to determine the comorbidities associated with hospitalization costs. A comorbidity network was built to complement and extend the results of the multivariate analysis.Results In total, 75.7% of COPD patients had comorbidities, and the number of comorbidities had an impact on the hospitalization cost. The results of multivariate analysis showed that the comorbidities contributing to hospital costs were pulmonary embolism, sick sinus syndrome, pneumomycosis, lymphoma, lung cancer, venous thromboembolism, aneurysm, cerebrovascular disease, chronic kidney disease, heart failure, diabetes, arteriosclerosis, obstructive sleep apnea-hypopnea syndrome, and fatty liver. The results of the comorbidity network analysis were consistent with those of the multivariate analysis.Conclusion The comorbidities can influence the burden of care for patients with COPD. Therefore, attention should be paid to early risk assessment and long-term interventions for these comorbidities in COPD patients.
Effect of Acetosyringone, Sucrose and Nutrients on Transgenic Hairy Root Induction in Chenopodium quinoa using different Rhizobium rhizogenesstrains
Authors: Massah Maedeh , Rabiei Mohammad 
Published: April 2023

Abstract
Quinoa is a plant with special nutritional and biological properties and tolerant in strict environmental conditions, which can be considered to a strategic product for the future food supply of mankind, as a pseudocereal. Quinoa root is rich in bioactive compounds with antimicrobial, antioxidant activity and diverse medicinal and nutritional properties that can have a potential for commercialization. The use of cultivation and propagation techniques in controlled laboratory conditions, such as the induction of differentiated tissues of hairy roots, allows the production of plants and the rapid and massive access to secondary metabolites. In this research, the induction of hairy roots was evaluated using four Rhizobium rhizogenes strains, including A4, A7, 11325, and ATCC 15834, in quinoa and the effect of different concentrations of acetosyringone and sucrose and removal of macro elements in the culture medium in increasing the rooting performance of R. rhizogenes was investigated. The results showed the different effects of the mutual effect of different concentrations of sucrose and acetosyringone, as well as the commonly used elements of the half strength MS culture medium on the biomass of hairy roots. The most optimal conditions for the induction of hairy roots culture were obtained in half strength MS culture medium, containing 30 g/l sucrose and 1 mM acetosyringone and without NH4NO3 salt. This efficient protocol provides a basis for future studies to be able to use the induced hairy root as a source of valuable secondary metabolites of quinoa root and create a new approach for exploiting the nutritional, medicinal and health compounds of the quinoa plant.
Gooseberry Anthocyanins Alleviates Insulin Resistance by Regulating Ceramide Metabolism in High Fat Diet Mice
Authors: Tang Xian , Gao Jun , Huang Jinpeng , Zhang Chenjuan , Liu Hongwei , Wei Jie 
Published: April 2023

Abstract
In order to explore the effect and mechanism of Gooseberry anthocyanins (GA) on reducing the ceramide content to reduce Insulin Resistance (IR) in mice.Molecular docking, Real-Time PCR and Western Blotting were used to explore the molecular mechanism and the effects of different doses GA in high-fat diet (HFD) mice.The results showed that the binding energy of anthocyanins on CerS6 was in the range of -8.2 to 5.2 kcal/mol, with low energy parameters and good binding positions. GA could effectively inhibit visceral fat, liver index, TC, TG and LDL-C, and improved HDL-C, GSH-Px and SOD.GA decreased the level of Insulin sensitivity index from-5.15 to-4.54 and improved insulin sensitivity and insulin resistance in HFD mice. Real-Time PCR and Western blotting results showed that GA could reducemRNA levels of inflammatory factors IL-6 and TNF-α, inhibit the expression of CerS6,PKCζ, PPARγ, CD36 and enhance the expression of SphK2, Akt, p-Akt/Akt, ISR. This study revealed the molecular mechanism of improving insulin resistance of GA in S1P/Cer signaling pathway, and provided theoretical support for preventive treatment of obesity related diseases by polyphenols.
The Vacuum-plasma Nanotechnologies Avinit
Authors: Sagalovych Olexiy , Sagalovych Vlad , Dudnik Stanislav F. , Olejnik Oleksandr k. , Popov Viktor 
Published: April 2023

Abstract
This paper reports the development of the Avinit vacuum plasma nanotechnology for applying multicomponent functional coatings and for modifying surfaces in order to improve the operational characteristics of materials, components, and parts for the aviation and technical purposes.
Underlying the technology are the processes of atomic-ion surface modification and the formation of nanolayer coatings under the influence of the nonequilibrium low-temperature plasma.
Special features of the Avinit nanotechnology include
· integrated application use of vacuum plasma processes activated by the nonequilibrium low-temperature plasma;
· the transition to a nano range to apply multi-component multilayer and nanolayer coatings with predefined characteristics.
In order to apply functional multilayer composite coatings, a technological vacuum-plasma automated cluster Avinit was devised and designed, which makes it possible to implement comprehensive methods for applying coatings (plasma-chemical CVD, vacuum-plasma PVD), the processes of ion saturation and ion surface treatment), combined within a single technological cycle.
The technological parameters of multilayer coating application processes have been refined in the "metal-nitrogen" and "metal-carbon" systems.
Experimental results of the metal-physical and tribological studies confirm the possibility of low-temperature (< 200 ºC) application of wear-resistant high-hard Avinit coatings based on metal nitrides and carbides under the modes that allow for good adhesion to the substrate materials (steel with precision surface Ra=0.025 µm) without reducing the strength characteristics of steel and without deterioration in the purity class of the resulting surface.
A new technique for strengthening and improving the wear resistance of articles made of steel and alloys by the Avinit N plasma precision nitriding in high-density plasma of nitrogen and argon has been developed. In this case, the formation process of a nitrided layer is significantly intensified, the hardness and wear resistance of parts increase without warping while maintaining the original geometric dimensions of the nitrided parts (precision nitriding "to size" with an accuracy of 1‒2 µm).
The reported results of the metal-physical and tribological studies are the basis for choosing coating materials to improve the efficiency of working surfaces of precision friction pairs in the "coating-steel" and "coating-coating" systems.
The paper gives examples of the industrial implementation of the Avinit technologies to increase the resource and reliability of aviation-technical articles in assembly and engine engineering.
Study of Systemic Disorders Associated With Pituitary Tumors in Damascus Hospital
Authors: Thuloj Obaida Ezzat , Alrawashdeh Mohammad Ahmad , Hammoud Taghrid 
Published: April 2023

Abstract
Background
Pituitary tumors are mostly benign masses and are rarely malignant. Pituitary tumors are either secretory or non-secretory tumors. Pituitary tumors are presented with a variety of symptoms based on the hormone that is secreted.
Methods
A cross-sectional study conducted in Damascus hospital containing 150 patients between the years 2012 and 2022 based on a specific inclusion and exclusion criteria.
Results
Results have shown a correlation between metabolic disorders and being female compared to males. In addition, gastrointestinal symptoms were noticeable in patients with a positive family history.
Conclusion
In this study patients with pituitary tumors presented with a variety of symptoms, which depicts the importance of having more studies done in the future regarding these conditions.
Natural Coumarin Derivatives Targeting Melanoma
Authors: Silva Leandro Rocha , Nunes Jéssica Alves , Zhan Peng , Łączkowski Krzysztof Z. , Cardoso Sílvia Helena , da Silva-Júnior Edeildo Ferreira 
Published: April 2023

Abstract:
In general, a cancerous process starts from uncontrolled cell growth, apoptosis,
and rapid proliferation of cellular clones, as well as, reactive oxygen species (ROS)
and imbalance of ROS-antioxidant production also could be involved in the genesis of
the disease. Cancer has accounted for millions of deaths worldwide every year, representing
a relevant threat to human lives. In this context, malignant melanoma represents the
most aggressive and deadliest type of cancer, leading to increased rates of patient deaths.
Natural active compounds have demonstrated their pharmacological benefits in several
different studies. Among these compounds, coumarin analogs have demonstrated promising
biological profiles, considering their efficacy and low toxicity. In this context, this
phytochemical oxygenated core has been broadly investigated since it presents several biological
properties of interest in the medicinal field. Herein, we reported a complete
compilation of studies focused on natural coumarins against melanoma, as well as, tyrosinase
since it is a cooper-catalyzed oxidase that performs an essential role during melanogenesis
(Eu-melanins and Pheo-melanins), which is associated with melanoma. Thus,
three different subclasses of natural coumarin were described in detail, such as simple
coumarin core, furanocoumarins, pyranocoumarins, and pyrone-substituents. Additionally,
insights on tyrosinase have been provided, allowing an overview of some structural/-
functional aspects of its enzyme, such as the presence of a binuclear type 3 cooper coordination
at the binding site of this target, acting as cofactors. Posteriorly, several coumarin-
based analogs with anti-tyrosinase activity also were reported and discussed. Finally,
we believe that unprecedented review can be a valuable source of information, which can
be used to design and develop novel coumarin-based analogs targeting melanoma and also
tyrosinase enzyme, contributing to the advances in the field of natural products.
Safety Analysis of Bapineuzumab in the Treatment of Mild to Moderate Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Authors: Gao Yaqi , Guo Jing , Zhang Fang , Li Yanfang 
Published: April 2023

Background:
Alzheimer’s disease affects millions of people worldwide, and very few
drugs are available for its treatment. Monoclonal antibodies have shown promising effects in the
treatment of various types of diseases. Bapineuzumab is one of the humanized monoclonal antibodies,
which have shown promising effects in AD patients. Bapineuzumab has shown efficacy in
the treatment of mild to moderate Alzheimer’s disease. However, its safety is still unclear.

Objective:
Thus, the main objective of the current study is to find out the exact safety profile of
bapineuzumab in the treatment of mild to moderate Alzheimer’s disease.

Methods:
We performed a web-based literature search of PubMed and clinical trial websites using
the relevant keywords. Data were extracted from eligible records, and the risk ratio (RR) was calculated
with a 95% confidence interval (CI). All the analyses were performed using Review Manager
software (version 5.3 for windows). Heterogeneity was measured by Chi-square and I-square
tests.

Results:
Non-significant association of bapineuzumab with serious treatment-emergent adverse
events [RR: 1.11 (0.92, 1.35)], headache [RR: 1.03 (0.81, 1.32)], delirium [RR: 2.21 (0.36, 13.53)],
vomiting [RR: 0.92 (0.55, 1.55)], hypertension [RR: 0.49 (0.12, 2.12)], convulsions [RR:2.23
(0.42, 11.71)], falls [RR: 0.98 (0.80, 1.21)], fatal AEs [RR: 1.18 (0.59, 2.39)], and neoplasms
[RR:1.81 (0.07, 49.52)] was reported; however, a significant association was found with vasogenic
edema [RR: 22.58 (3.48, 146.44)].

Conclusion:
Based on available evidence, bapineuzumab is found to be safe in the treatment of
AD patients. However, vasogenic edema should be considered.
Synthesis of 5-(trifluoroacetyl)imidazoles from Bromoenones and
Benzimidamides via Aza-Michael Initiated Ring Closure Reaction
Authors: Romanov Alexey R. , Kondrashov Evgeniy V. , Zinchenko Sergey V. 
Published: April 2023

Introduction:
A simple method for the preparation of 5-(trifluoroacetyl)imidazoles was
elaborated.

Methods:
The reaction of trifluoromethyl(α-bromoalkenyl)ketones with benzimidamides was employed
to afford the target heterocycles in good yields.

Results:
The assembly of imidazole core proceeds via aza-Michael adduct formation followed by
intramolecular nucleophilic substitution and spontaneous aromatization as an oxidation sequence.

Conclusion:
The yields of target imidazoles can be improved by the use of soft oxidizing agents.
Phytochemical Constituents’ Analysis of Rhanterium adpressum Coss &
Durieu Flowers Extracts and their α-amylase and α-glucosidase Inhibition
Properties
Authors: Boussoussa Hadjer , Benabed Houda Khadidja , Khacheba Ihcen , Yousfi Mohamed 
Published: April 2023

Background:
Rhanterium adpressum is an endemic and desert plant found in Algerian Sahara,
it is used by the local population in cheese production and folk medicine as an antidiuretic and antimicrobial.

Objective:
This study aimed to analyse the phytochemical composition of Rhanterium adpressum extracts
by GC-MS and assess their inhibitory potential on α-amylase and α-glucosidase enzymes linked
to diabetes.

Methods:
Two solvents were used for extraction: petroleum ether and dichloromethane. The obtained
extracts were then analysed by GC-MS and in vitro tested for their antidiabetic activity.

Results:
GC-MS analysis of extracts from R. adpressum flowers revealed various phytocompounds,
such as (-)-Spathulenol, alpha.-Amyrin, Lupeol and Cedran-diol in petroleum ether extract; 1HCycloprop[
e]azulen-7-ol, 5(1H)-Azulenone and alpha-cardinol in dichloromethane extract. Petroleum
ether extract exhibited a good in vitro antidiabetic activity in comparison to dichloromethane extract.

Conclusion:
This research confirms the antidiabetic activity of petroleum ether extract when compared
with dichloromethane extract; other studies are needed for purification and in vivo study of biocompounds
from Rhanterium adpressum. This investigation offers scientific data that flowers of
Rhanterium adpressum exhibit in vitro anti-diabetic effect.
Association between Glucose-lowering Treatments and Risk of Diabetic
Retinopathy in People with Type 2 Diabetes: A Nationwide Cohort Study
Authors: Hasselstrøm  Jensen Jakob , Vestergaard Peter , Hasselstrøm Jensen Morten 
Published: April 2023

Introduction:
Glycaemic variability is possibly linked to the development of diabetic
retinopathy, and newer second-line glucose-lowering treatments in type 2 diabetes might reduce
glycaemic variability.

Aim:
This study aimed to investigate whether newer second-line glucose-lowering treatments are
associated with an alternative risk of developing diabetic retinopathy in people with type 2 diabetes.

Methods:
A nationwide cohort of people with type 2 diabetes on second-line glucose-lowering
treatment regimens in 2008-2018 was extracted from the Danish National Patient Registry. Adjusted
time to diabetic retinopathy was estimated with a Cox Proportional Hazards model. The model
was adjusted for age, sex, diabetes duration, alcohol abuse, treatment start year, education, income,
history of late-diabetic complications, history of non-fatal major adverse cardiovascular events,
history of chronic kidney disease, and history of hypoglycaemic episodes.

Results:
Treatment regimens of metformin + basal insulin (HR: 3.15, 95% CI: 2.42-4.10) and metformin
+ glucagon-like peptide-1 receptor agonist (GLP-1-RA, HR: 1.46, 95% CI: 1.09-1.96) were
associated with an increased risk of diabetic retinopathy compared with metformin + dipeptidyl
peptidase-4 inhibitors (DPP-4i). Treatment with metformin + sodium–glucose cotransporter-2 inhibitor
(SGLT2i, HR: 0.77, 95% CI: 0.28-2.11) was associated with the numerically lowest risk of
diabetic retinopathy compared with all regimens investigated.

Conclusion:
Findings from this study indicate that basal insulin and GLP-1-RA are suboptimal second-
line choices for people with type 2 diabetes at risk of developing diabetic retinopathy. However,
many other considerations concerning the choice of second-line glucose-lowering treatment
for type 2 diabetes patients should be taken into account.
Assessment of Small Diameter Steel Pile as a Stabilizing Element for Transmission Tower Slope Stability
Authors: Binti Katman Herda Yati , Lee Choon Yong , Zulnisyam Dalia Utama , Baharuddin Intan Nor Zuliana , Pauzi Nur Irfah Mohd 
Published: April 2023

Background:
Stabilization of unstable slopes with relatively large reinforced concrete piles has been widely adopted over the past several decades. Small diameter steel piles have several advantages as a slope reinforcement technique for an unstable transmission tower slope where space and access restrictions that typically occur render alternate approaches unfeasible.

Methods:
In this study, a numerical performance assessment of small diameter steel pile as a stabilizing element for transmission tower slope stability was carried out using an uncoupled analysis, in which the pile response and slope stability are considered separately. Numerical evaluations are presented and the influencing parameters that could affect the behavior of reinforcing piles to increase transmission tower slope stability are investigated.

Results:
The numerical analysis results indicate that the soil properties, slope geometry, pile location, pile diameter, pile length and number of pile rows have a combined effect on the performance of small diameter steel piles to stabilize transmission tower slopes.

Conclusion:
The numerical assessment can satisfactorily capture some fundamental response of transmission tower slope reinforced with multi-row small diameter steel piles.