bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-1 Receptor Antagonist, Mode of Analgesia and Risk of Cesarean Delivery After Onset of Labor: A Mendelian Randomization Analysis
Authors: Ackland G.L. , Van Duijvenboden S. , Abbott T.E.F. , Gutierrez del Arroyo A. , Wilson M.J. , David A.L. ,   the EPIFEVER-2 Investigators
Published: September 2023

(Br J Anaesth. 2022;128:89–97)
Inflammation during labor can cause a host of complications that can in turn lead to emergency cesarean delivery due to increased risks to both mother and child. The body has natural responses to inflammation, one of which is the release of an anti-inflammatory cytokine, an interleukin-1 receptor antagonist (IL-1ra). The gene that encodes the expression of IL-1ra has 2 upstream alleles that increase mRNA expression and IL-1ra concentration. Previously in similar situations where genes have been identified and associated, Mendelian randomization techniques have been able to show causal relationships between the genes and observable outcomes.
Promoting Connection in the Faith Community Through Letter Writing
Authors: Long Elizabeth M. 
Published: September 2023

ABSTRACT:
Faith community nurses can reduce loneliness and provide connection for homebound members of faith communities through promotion of letter writing. Undergraduate nursing students who were matched with members of their own faith community wrote letters to older adults for 10 weeks as a community service-learning project. Data from the UCLA Loneliness Scale pre- and post-intervention showed reduced loneliness and greater connection among recipients of the letters.
Therapy Dog Presence in an Undergraduate Nursing Program
Authors: Bellflowers Lois A. , Ruttencutter Gwen Scott 
Published: September 2023

ABSTRACT:
Research supports the use of animal-assisted interactions and pet therapy in various settings. Undergraduate nursing students experience high levels of stress and anxiety which often continue as they become professional nurses. Entering the workforce equipped with positive coping strategies may help newly licensed nurses to combat stressors. This qualitative descriptive study examined the experiences of undergraduate nursing students with the presence of a therapy dog. Four major themes regarding the role of therapy dogs were identified: as a coping strategy, as a mood moderator, as a positive distraction, and for community building.
Clinical and Hemodynamic Improvement in Pulmonary Hypertension After Switching to Sacubitril/Valsartan in Patients With Heart Failure With Preserved Ejection Fraction
Authors: Brockmöller Janine , Ivanoski Stevan , Hundack Lukas , Blohm Jan-Henrik , Januszewski Monika , Remppis Bjoern Andrew , Burgdorf Christof 
Published: September 2023

Abstract:
Patients with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension have poor survival, and established medical therapies for both conditions are not available. In this retrospective study of 69 patients with HFpEF and either isolated postcapillary pulmonary hypertension (IpcPH, n = 53) or combined postcapillary and precapillary pulmonary hypertension (CpcPH, n = 16), we investigated the effects of sacubitril/valsartan on pulmonary hypertension measured using right heart catheterization at baseline (ie, presacubitril/valsartan) and 99 (94–123) days after switching to sacubitril/valsartan. After switching to sacubitril/valsartan, right heart catheterization showed significantly lower pulmonary artery pressures (systolic/diastolic/mean) in both patient groups compared with presacubitril/valsartan [IpcPH: 44 (38–52)/15 (12–19)/28 (22–33) mm Hg vs. 47 (40–55)/18 (15–23)/31 (26–35) mm Hg, P < 0.01; CpcPH: 54 (43–57)/18 (12–23)/34 (30–36) mm Hg vs. 61 (50–79)/24 (19–30)/40 (31–53) mm Hg, P < 0.05]. The median sacubitril/valsartan dose at follow-up was 24/26 (24/26–49/51) mg twice daily in both patients with IpcPH and CpcPH. Clinically, the New York Heart Association functional class improved by at least 1 class in 32 of 69 patients (P < 0.01). In conclusion, sacubitril/valsartan therapy improves pulmonary hypertension in patients with HFpEF and either IpcPH or CpcPH. Further prospective randomized trials are needed for confirmation of our results.
Functional involvement of endothelial lipase in hepatitis B virus infection
Authors: Shirasaki Takayoshi , Murai Kazuhisa , Ishida Atsuya , Kuroki Kazuyuki , Kawaguchi Kazunori , Wang Ying , Yamanaka Souma , Yasukawa Rio , Kawasaki Narumi , Li Ying-Yi , Shimakami Tetsuro , Sumiyadorj Ariunaa , Nio Kouki , Sugimoto Saiho , Orita Noriaki , Takayama Hideo , Okada Hikari , Thi Bich Phuong Doan , Iwabuchi Sadahiro , Hashimoto Shinichi , Ide Mayuko , Tabata Noriko , Ito Satoru , Matsushima Kouji , Yanagawa Hiroshi , Yamashita Taro , Kaneko Shuichi , Honda Masao 
Published: September 2023

Background:
HBV infection causes chronic liver disease and leads to the development of HCC. To identify host factors that support the HBV life cycle, we previously established the HC1 cell line that maintains HBV infection and identified host genes required for HBV persistence.

Methods:
The present study focused on endothelial lipase (LIPG), which binds to heparan sulfate proteoglycans (HSPGs) in the cell membrane.

Results:
We found HBV infection was impaired in humanized liver chimeric mouse-derived hepatocytes that were transduced with lentivirus expressing short hairpin RNA against LIPG. Long-term suppression of LIPG combined with entecavir further suppressed HBV replication. LIPG was shown to be involved in HBV attachment to the cell surface by using 2 sodium taurocholate cotransporting peptide (NTCP)-expressing cell lines, and the direct interaction of LIPG and HBV large surface protein was revealed. Heparin and heparinase almost completely suppressed the LIPG-induced increase of HBV attachment, indicating that LIPG accelerated HBV attachment to HSPGs followed by HBV entry through NTCP. Surprisingly, the attachment of a fluorescently labeled NTCP-binding preS1 probe to NTCP-expressing cells was not impaired by heparin, suggesting the HSPG-independent attachment of the preS1 probe to NTCP. Interestingly, attachment of the preS1 probe was severely impaired in LIPG knockdown or knockout cells. Inhibitors of the lipase activity of LIPG similarly impaired the attachment of the preS1 probe to NTCP-expressing cells.

Conclusions:
LIPG participates in HBV infection by upregulating HBV attachment to the cell membrane by means of 2 possible mechanisms: increasing HBV attachment to HSPGs or facilitating HSPG-dependent or HSPG-independent HBV attachment to NTCP by its lipase activity.
Sarcoid Granuloma of the Choroid and Ciliary Body in 50 Cases
Authors: Baş Zeynep , Sajjadi Zaynab , Shields Carol L. 
Published: September 2023

Abstract

Precis:
Analysis of 50 patients with sarcoid granuloma of the choroid/ciliary body revealed granulomas with yellow color (41,82%) and irregular vermiform margins (46,92%). Imaging features included clear subretinal fluid (6,12%), dirty subretinal fluid (14,28%), and cystoid macular edema (1,2%).Systemic sarcoidosis was detected during ophthalmic care (4,8%) or diagnosed after presentation (3,6%).

Purpose:
To describe the clinical and imaging features of sarcoid granuloma of the choroid and ciliary body.

Methods:
Retrospective case series of patients with choroid and/or ciliary body sarcoid granuloma managed at the Ocular Oncology Service at Wills Eye Hospital.

Results:
The mean patient age at diagnosis was 51.0 years (54.1, 11.0-83.8 years). The mean logMAR visual acuity at presentation was 0.3 (0.2, 0.0-3.0)[Snellen equivalent 20/40 (20/30, HM-20/20)]. Clinical features included mean basal dimension of 5.2 mm (4.0, 0.3-20.0 mm) and thickness of 1.7 mm (1.8, 0.0-3.6 mm), yellow color (41, 82%), multifocality (18, 36%), and irregular vermiform margins (46, 92%). Related clinical features included inflammation of the anterior chamber (1, 2%), vitreous (5, 10%), and retina (5, 10%). Imaging features by optical coherence tomography of the choroid lesions (n=49) demonstrated clear subretinal fluid (6, 12%), “dirty” subretinal fluid (14, 28%), cystoid macular edema (1, 2%), overlying retinal edema (6, 12%), and localized vitreous cellularity (1, 2%). Management included sub-Tenon’s triamcinolone (11, 22%), intravitreal triamcinolone (3, 6%), systemic corticosteroids (19, 38%), or observation (26, 52%). Systemic sarcoidosis was present prior to ocular diagnosis (13, 26%), detected during ophthalmic care (4, 8%), detected after ocular diagnosis (3, 6%), or not found (30, 60%) over mean follow-up of 13.7 months (6.9, 0.0-138.2).

Conclusions:
Sarcoid granuloma of the choroid and/or ciliary body can manifest without anterior segment or vitreous/retina inflammation in many cases and reveal underlying systemic sarcoidosis in 40% of cases. A distinguishing feature of choroidal sarcoid granuloma was its vermiform margin.
Higher Triad Risk Scores Are Associated With Increased Risk for Trabecular-Rich Bone Stress Injuries in Female Runners
Authors: Roche Megan , Nattiv Aurelia , Sainani Kristin , Barrack Michelle , Kraus Emily , Tenforde Adam , Kussman Andrea , Olson Emily Miller , Kim Brian , Fahy Katherine , Miller Emily , Diamond Elyse , Meraz Sonya , Singh Sonal , Nattiv Aurelia , Fredericson Michael 
Published: September 2023

Objective:
Bone stress injuries (BSIs) in trabecular-rich bone are associated with greater biological risk factors compared with cortical-rich bone. We hypothesized that female runners with high Female Athlete Triad (Triad)-related risk would be at greater risk for trabecular-rich BSIs than runners with low Triad-related risk.

Design:
Prospective cohort study.

Setting:
Two NCAA institutions.

Participants:
Female runners were followed prospectively for up to 5 years.

Intervention:
The intervention consisted of team nutrition presentations focused on optimizing energy availability plus individualized nutrition sessions. Triad Cumulative Risk Assessment (CRA) categories were assigned yearly based on low-energy availability, menstrual status, age of menarche, low body mass index, low bone mineral density, and prior BSI.

Main Outcome Measures:
The outcome was the annual incidence of trabecular- and cortical-rich BSI. Generalized Estimating Equations (GEE, to account for the correlated nature of the observations) with a Poisson distribution and log link were used for statistical modeling.

Results:
Cortical-rich BSI rates were higher than trabecular-rich BSI rates (0.32 vs 0.13 events per person-year). Female runners with high Triad-related risk had a significantly higher incidence rate ratio of trabecular-rich BSI (RR: 4.40, P = 0.025) and cortical-rich BSI (RR: 2.87, P = 0.025) than women with low Triad-related risk. Each 1-point increase in Triad CRA score was associated with a significant 26% increased risk of trabecular-rich BSI (P = 0.0007) and a nonsignificant 14% increased risk of cortical-rich BSI (P = 0.054).

Conclusions:
Increased Triad CRA scores were strongly associated with increased risk for trabecular-rich BSI. Incorporating Triad CRA scores in clinical care could guide BSI prevention.
Neuropsychiatric adverse effects from CFTR modulators deserve a serious research effort
Authors: VanElzakker Michael B. , Tillman Emma M. , Yonker Lael M. , Ratai Eva-Maria , Georgiopoulos Anna M. 
Published: September 2023

Purpose of review
This review highlights the problem of neuropsychiatric adverse effects (AEs) associated with elexacaftor/tezacaftor/ivacaftor (ETI), current suboptimal mitigation approaches, a novel testable mechanistic hypothesis, and potential solutions requiring further research.

Recent findings
Studies show that a minority of persons with cystic fibrosis (PwCF) initiating cystic fibrosis transmembrane conductance regulator (CFTR) modulators experience neuropsychiatric AEs including worsening mood, cognition, anxiety, sleep, and suicidality. The GABA-A receptor is a ligand-gated chloride channel, and magnetic resonance spectroscopy neuroimaging studies have shown that reduced GABA expression in rostral anterior cingulate cortex is associated with anxiety and depression. Recent research details the impact of peripheral inflammation and the gut-brain axis on central neuroinflammation. Plasma ETI concentrations and sweat chloride have been evaluated in small studies of neuropsychiatric AEs but not validated to guide dose titration or correlated with pharmacogenomic variants or safety/efficacy.

Summary
Although ETI is well tolerated by most PwCF, some experience debilitating neuropsychiatric AEs. In some cases, these AEs may be driven by modulation of CFTR and chloride transport within the brain. Understanding biological mechanisms is a critical next step in identifying which PwCF are likely to experience AEs, and in developing evidence-based strategies to mitigate them, while retaining modulator efficacy.
Budget impact analysis of temocillin insurance coverage for urinary tract infections caused by ESBL-producing pathogens in Iran
Authors: Seyedifar Meysam , Sabouri Menhajuddin , Soodi Omid , Ghasemi Hananeh 
Published: September 2023

Background:
One of the most prevalent infections with a significant disease burden is urinary tract infections (UTIs), which occurs in approximately 50% of women at least once in their lifetime. Antimicrobial resistance to pathogens causing UTIs is expanding worldwide and has been associated with increased use of broad-spectrum antibiotics, including carbapenems, leading to significant costs for insurance and healthcare systems. The emergence of resistance to carbapenems has led to an increasing need for and interest in carbapenem-sparing strategies, including the use of narrow-spectrum antibiotics, such as temocillin. Temocillin has a strong bactericidal effect, along with high tolerability and a good safety profile. It is also stable toward most extended-spectrum beta-lactamases (ESBL). The purpose of our study was to design a budget impact analysis (BIA) model and estimate the budget impact of temocillin insurance coverage for the treatment of UTIs caused by ESBL-producing bacteria from the perspective of the payer.

Methods:
The BIA model with insurance payer perspective was used to estimate the impact of temocillin insurance coverage on the treatment of UTIs caused by ESBL-producing bacteria over a 1-year time horizon in Iran. Direct medicine costs, hospitalization and paraclinical costs, and side effect costs were considered in this model. To assess the impact of uncertainty on the model inputs, 1-way sensitivity analyses were performed.

Results:
The model demonstrates that inclusion of temocillin in insurance coverage, decreasing treatment costs from $36 million to $34 million, will result in overall savings of > $1.9 million and lead to > $9 million savings in insurance costs for antimicrobial resistance.

Conclusion:
The inclusion of temocillin in the insurance coverage in Iran for patients developing UTIs caused by ESBL-producing bacteria would be cost-saving for insurance and decrease the risk associated with emerging antimicrobial resistance.
Accurate diagnosis of pulmonary inflammatory myofibroblastic tumor by imaging technology before operation: A case report
Authors: Sun Lv , Zhu Yuhang , Chen Cheng , Huang Jiajia , Li Bangguo 
Published: September 2023

Rationale:
Pulmonary inflammatory myofibroblastic tumor (IMT) is a rare borderline tumor, which has the potential of malignant including invasion of surrounding tissues, distant metastasis and recurrence. However, the preoperative diagnosis is difficult and it can also be difficult to distinguish from malignancy in small tissue samples. Preoperative accurate diagnosis has important clinical significance for patients to choose treatment measures and improve the quality of rehabilitation. We was examined by computed tomography (CT) plain scan plus enhanced scan, magnetic resonance diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) imaging technology in an adult female, compared with lung cancer and pulmonary cryptococcus infection for diagnosis of pulmonary IMT.

Patient concerns:
A 32-year-old female patient was admitted to the hospital “physical examination revealed nodules in the right upper lung for 1 week”.

Diagnoses:
The patient was diagnosed with Pulmonary inflammatory myofibroblastic tumor.

Interventions:
Single-port thoracoscopic lobectomy was performed after multidisciplinary consultation.

Outcomes:
DWI and ADC improves the accuracy of preoperative diagnosis and well guides the formulation of treatment measures. The combined CT, DWI, and ADC magnetic resonance imaging technology has more important significance in the diagnosis and differential diagnosis of IMT and lung malignant tumors.

Lessons:
Although accurate preoperative diagnosis of pulmonary IMT is difficult. Chest CT examination combined with DWI and ADC imaging technology has high clinical significance for the diagnosis of IMT.
Bevacizumab-induced arrhythmia in a patient with lung adenocarcinoma: A case report
Authors: Li Jing , Zhang Furong , Lu Yuanyuan 
Published: September 2023

Rationale:
Cardiotoxicity is an important side effect of vascular endothelial growth factor inhibitors therapy in the treatment of cancer. Massive studies have shown bevacizumab-related hypertension, venous, and arterial thrombosis.

Patient concerns:
A 56-year-old female patient was treated with bevacizumab monotherapy for lung adenocarcinoma. The patient was detected a poor R-wave increase with slight ST segment elevation in V1–V3 leads, and ventricular arrhythmia.

Diagnosis:
The incidental arrhythmia caused by bevacizumab was considered.

Interventions:
The patients received aspirin and amiodarone (0.2 g tid) to treat arrhythmia. After consultation with the cardiology department, the patient received a diagnostic coronary angiography. Coronary angiography showed 30% of the right coronary artery stenoses and no obvious organic stenosis in the left main artery, left anterior ascending, or left circumflex.

Outcomes:
The patient exhibited disappearance of chest tightness and rapid heartbeat after the treatment of amiodarone. Electrocardiogram monitoring results returning to normal.

Lessons:
This is the first reported case of bevacizumab-associated arrhythmia. It is advisable to consider the risk of arrhythmia in bevacizumab monotherapy or combines treatment.
Efficacy and safety of transarterial chemoembolization plus lenvatinib in the treatment of advanced hepatocellular carcinoma: A meta-analysis
Authors: Li Dailong , Liu Siqi , Cheng Chunlai , Xu Lu , Zhao Pingfan 
Published: September 2023

Background:
The benefits of transarterial chemoembolization (TACE) plus lenvatinib in advanced hepatocellular carcinoma (HCC) remain controversial. Therefore, we performed a meta-analysis to evaluate the efficacy and safety of TACE plus lenvatinib in the treatment of advanced HCC.

Methods:
Up to February 26, 2023, the databases of PubMed, EMBASE, Cochrane Library, ClinicalTrials.gov, China National Knowledge Infrastructure, and Wanfang were searched, and clinical studies of TACE plus lenvatinib (experimental group) versus TACE or lenvatinib (control group) in the treatment of advanced HCC were included. Two researchers independently screened the literature, extracted data, and evaluated the quality of the included literature. Revman5.4 software was used for meta-analysis.

Results:
A total of 1855 patients were included in 18 studies. The results of the meta-analysis showed that TACE plus lenvatinib could increase the objective response rate (ORR) (odds ratio [OR] = 3.25, 95% confidence interval [CI]: 2.46–4.31; OR = 3.55, 95%CI: 2.53–4.97) and disease control rate (DCR) (OR = 3.27, 95%CI: 2.44–4.38; OR = 3.45, 95%CI: 2.28–5.24), 12-month (OR = 3.43, 95%CI: 2.08–5.65; OR = 2.78, 95%CI: 1.90–4.05) and 18-month (OR = 2.97, 95%CI: 1.77–5.00; OR = 2.62, 95%CI: 1.54–4.47) progression-free survival (PFS) rate, 12-month (OR = 2.34, 95%CI: 1.53–3.58; OR = 3.64, 95%CI: 2.65–5.01) and 18-month (OR = 2.27, 95%CI: 1.48–3.48; OR = 3.23, 95%CI: 2.33–4.48) overall survival (OS) rate compared with TACE or lenvatinib alone. In addition, the experimental group could significantly reduce the expression levels of serum alpha-fetoprotein (AFP) (standard mean difference [SMD] = 1.22, 95%CI: 0.67–1.78) and vascular endothelial growth factor (VEGF) (SMD = 1.27, 95%CI: 0.87–1.67). In terms of adverse events of drugs, the incidence of grade ≥ 3 hypertension and elevated aspartate aminotransferase and alanine aminotransferase in the experimental group was higher than that in the control group (P < .05).

Conclusion:
Compared with TACE or lenvatinib alone, TACE plus lenvatinib has achieved remarkable efficacy in patients with advanced HCC, and the efficacy versus risk need to be carefully balanced in clinical application.
Diagnostic accuracy of MUC7 expression for bladder cancer: A systematic review and meta-analysis
Authors: Zhang Jiwang , Li Zhou 
Published: September 2023

Background:
There have been many studies on MUC7 and bladder cancer (BC) that have been published; however, all sample sizes were not enough which led to their conclusions being based on small samples. Therefore, this meta-analysis aims to systematically analyze the diagnostic value of MUC7 for bladder cancer and provide a scientific basis for the diagnosis of bladder cancer.

Methods:
To obtain relevant literature on MUC7 diagnosed bladder cancer, databases such as PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang data, Chongqing VIP, and Chinese Biomedical Literature Database were searched from the establishment of the database to July 11, 2023. According to established inclusion and exclusion criteria, literature was screened and data were extracted. The Quality Assessment of Diagnostic Accuracy Studies 2 was used to evaluate the risk of bias and applicability of included literature. Meta-disc1.4 and Stata12.0 software were used for Meta-analysis.

Results:
Twelve studies were included, including728 BC patients and 458 non-BC controls. The pooled sensitivity and pooled specificity were 0.74 (95% confidence interval [CI]: 0.71–0.77) and 0.92 (95% CI: 0.90–0.95), respectively. The pooled negative likelihood ratio was 0.27 (95% CI: 0.20–0.36), and the pooled positive likelihood ratio was 9.58 (95% CI: 5.40–17.00). The diagnostic odds ratio was 40.95 (95% CI: 20.31–82.59), and the area under the curve was 0.91 in the overall summary of the receiver operating characteristic curve.

Conclusion:
MUC7 might be a potential biomarker for diagnosing BC. However, more large sample and multicenter studies are needed to prove whether it can be used in clinical diagnosis.