bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-incision laparoscopic transabdominal preperitoneal hernioplasty: 1,054 procedures and experience
Authors: Jiao Jingyi , Zhu Xiaojun , Zhou Chun , Wang Peng 
Published: May 2023

Abstract
Purpose
Although there have been numerous studies on single-incision laparoscopic inguinal hernia repair (SIL-IHR), the short- and long-term outcomes in patients from a large single institution who underwent single-incision laparoscopic transabdominal preperitoneal hernioplasty (SIL-TAPP) have rarely been reported. The purpose of this study is to evaluate the short- and long-term outcomes of SIL-TAPP and its safety and feasibility in patients from a large single institution.

Methods
The details of 1,054 procedures in 966 patients who underwent SIL-TAPP at the Affiliated Hospital of Nantong University from January 2015 to October 2022 were retrospectively analysed. SIL-TAPP was performed completely through the umbilicus using conventional laparoscopic instruments. Short-term and long-term outcomes of SIL-TAPP were collected by outpatient and telephone follow-ups. In addition, we further compared the operation time, length of postoperative hospital stay, and postoperative complications of patients with simple and complicated unilateral inguinal hernias.

Results
A total of 1,054 procedures were performed for 878 unilateral inguinal hernias and 88 bilateral inguinal hernias. In total, there were 803 (76.2%) indirect inguinal hernias, 192 (18.2%) direct inguinal hernias, 51 (4.8%) femoral hernias and 8 (0.8%) combined hernias. The mean operative time was 35.5 ± 17.0 min for unilateral inguinal hernias and 51.9 ± 25.5 min for bilateral inguinal hernias. There was one (0.1%) conversion to two-incision laparoscopic transabdominal preperitoneal hernioplasty. No intraoperative haemorrhages, inferior epigastric vessel injury or nerve damage occurred. Postoperative complications were minor and could be resolved without surgical intervention. The mean length of hospital stay was 1.3 ± 0.8 days. The median follow-up was 44 months, no trocar hernia occurred, and there was one (0.1%) recurrence. The operation time in the complicated inguinal hernia group was significantly higher than that in the simple inguinal hernia group (38.9 ± 22.3 vs. 35.0 ± 15.6, p = 0.025). The length of postoperative hospital stay and complication rate of the complicated inguinal hernia group were slightly higher than those of the simple inguinal hernia group, but the difference was not statistically significant.

Conclusion
SIL-TAPP is safe and technically feasible, and both short- and long-term outcomes are acceptable.
Tolerant macaque species are less impulsive and reactive
Authors: Loyant Louise , Waller Bridget M. , Micheletta Jérôme , Meunier Hélène , Ballesta Sébastien , Joly Marine 
Published: May 2023

AbstractInhibitory control, the inhibition of impulsive behaviours, is believed to be key in navigating a complex social environment. Species characterised by higher social tolerance, living in more complex groups, with more diverse relationships, face higher uncertainty regarding the outcome of social interactions and, therefore, would benefit from employing more inhibitory strategies. To date, little is known about the selective forces that favour the evolution of inhibitory control. In this study, we compared inhibitory control skills in three closely related macaque species which differ in their social tolerance style. We tested 66 macaques from two institutions (Macaca mulatta, low tolerance; M. fascicularis, medium tolerance; and M. tonkeana, high tolerance) using a battery of validated inhibitory control touchscreen tasks. Higher social tolerance was associated with enhanced inhibitory control performances. More tolerant species were less impulsive and less distracted by pictures of unknown conspecifics. Interestingly, we did not find evidence that social tolerance degree was associated with performance in reversal learning. Overall, our results support the hypothesis that evolution has promoted the development of socio-cognitive skills to cope with the demands related to the complexity of the social environment.
Leading Without a Self: Implications of Buddhist Practices for Pseudo-spiritual Leadership
Authors: Fry Louis W. , Vu Mai Chi 
Published: May 2023

AbstractThis paper extends Being-centered and spiritual leadership theory using non-self from the Buddhist philosophy to further our understanding of how inner life functions as the source of spiritual leadership. While spiritual leadership theory has received widespread acceptance and considerable empirical support, its developmental process and potential for being used to pursue self-centered ends remain underdeveloped. Drawing on non-self from the Buddhist emptiness theory, we identify different egoistic forms of attachment at each level of being that can lead to forms of suffering in spiritual leadership. Then we show how leaders operating at lower levels of being can fall into the trap of practicing a form of pseudo-spiritual leadership that is overly focused on self-centered or instrumental purposes and economic rationality. We then introduce mechanisms to move beyond pseudo-spiritual leadership practices and discuss implications for future theory, research, and practice.
On a Computationally Ill-Behaved Bilevel Problem with a Continuous and Nonconvex Lower Level
Authors: Beck Yasmine , Bienstock Daniel , Schmidt Martin , Thürauf Johannes 
Published: May 2023

AbstractIt is well known that bilevel optimization problems are hard to solve both in theory and practice. In this paper, we highlight a further computational difficulty when it comes to solving bilevel problems with continuous but nonconvex lower levels. Even if the lower-level problem is solved to $$\varepsilon $$
ε
-feasibility regarding its nonlinear constraints for an arbitrarily small but positive $$\varepsilon $$
ε
, the obtained bilevel solution as well as its objective value may be arbitrarily far away from the actual bilevel solution and its actual objective value. This result even holds for bilevel problems for which the nonconvex lower level is uniquely solvable, for which the strict complementarity condition holds, for which the feasible set is convex, and for which Slater’s constraint qualification is satisfied for all feasible upper-level decisions. Since the consideration of $$\varepsilon $$
ε
-feasibility cannot be avoided when solving nonconvex problems to global optimality, our result shows that computational bilevel optimization with continuous and nonconvex lower levels needs to be done with great care. Finally, we illustrate that the nonlinearities in the lower level are the key reason for the observed bad behavior by showing that linear bilevel problems behave much better at least on the level of feasible solutions.
Target for campaign success: an empirical analysis of equity crowdfunding in Japan
Authors: Honjo Yuji , Kurihara Koki 
Published: May 2023

AbstractThis study investigates campaign success in equity crowdfunding, using campaigns listed on a leading Japanese equity crowdfunding platform with an all-or-nothing rule. We examine how campaign success depends on campaign- and firm-specific characteristics, including the campaign target amount. We find that patenting positively affects campaign success and the campaign target amount. The results indicate that innovative firms have a higher probability of campaign success, while they set a higher target amount. We also provide evidence that campaigns that have already provided services and products have a lower probability of success, although not always significant, and firms tend to set a lower target amount. Moreover, campaigns launched by venture capital-backed firms are more likely to succeed than others. Furthermore, campaigns launched by firms eligible for the Angel Tax System, introduced in Japan as a tax incentive for investment in young and small firms, have a higher tendency to succeed in equity crowdfunding. Our findings suggest that the Angel Tax System attract more crowd investors and such tax incentives help raise funds on equity crowdfunding platforms for new businesses.
Recurrent neural networks for generalization towards the vessel geometry in autonomous endovascular guidewire navigation in the aortic arch
Authors: Karstensen Lennart , Ritter Jacqueline , Hatzl Johannes , Ernst Floris , Langejürgen Jens , Uhl Christian , Mathis-Ullrich Franziska 
Published: May 2023

Abstract
Purpose
Endovascular intervention is the state-of-the-art treatment for common cardiovascular diseases, such as heart attack and stroke. Automation of the procedure may improve the working conditions of physicians and provide high-quality care to patients in remote areas, posing a major impact on overall treatment quality. However, this requires the adaption to individual patient anatomies, which currently poses an unsolved challenge.

Methods
This work investigates an endovascular guidewire controller architecture based on recurrent neural networks. The controller is evaluated in-silico on its ability to adapt to new vessel geometries when navigating through the aortic arch. The controller’s generalization capabilities are examined by reducing the number of variations seen during training. For this purpose, an endovascular simulation environment is introduced, which allows guidewire navigation in a parametrizable aortic arch.

Results
The recurrent controller achieves a higher navigation success rate of 75.0% after 29,200 interventions compared to 71.6% after 156,800 interventions for a feedforward controller. Furthermore, the recurrent controller generalizes to previously unseen aortic arches and is robust towards size changes of the aortic arch. Being trained on 2048 aortic arch geometries gives the same results as being trained with full variation when evaluated on 1000 different geometries. For interpolation a gap of 30% of the scaling range and for extrapolation additional 10% of the scaling range can be navigated successfully.

Conclusion
Adaption to new vessel geometries is essential in the navigation of endovascular instruments. Therefore, the intrinsic generalization to new vessel geometries poses an essential step towards autonomous endovascular robotics.
Können plakatbezogene Nudges zum Treppensteigen animieren?
Authors: Boyde Isabell , Ewert Benjamin , Dadaczynski Kevin 
Published: May 2023

Zusammenfassung
Hintergrund
Bewegungsmangel ist mitverantwortlich für die Entstehung nichtübertragbarer Krankheiten und zählt zu einem der führenden Risikofaktoren für frühzeitige Todesfälle. Treppensteigen bietet eine niedrigschwellige Möglichkeit, das Aktivitätsniveau im Alltag zu steigern. Studien berichten über positive Effekte von sog. „Nudges“ in Zusammenhang mit Maßnahmen zur Bewegungsförderung.

Zielstellung
Dieser Beitrag stellt das Nudge-basierte Pilotprojekt „Marburg. Geht doch!“ vor und überprüft dessen Wirkung auf die niedrigschwellige körperliche Aktivität (Nutzung der Treppe).

Methodik
Die Überprüfung von Unterschieden im Treppennutzungsverhalten erfolgte durch nicht-teilnehmende Beobachtungen vor sowie 2 Wochen nach Initiierung der Nudge-Intervention mithilfe eines standardisierten Beobachtungsbogens sowie Feedbackgesprächen mit Passant*innen (nBZP1 = 2118, nBZP2 = 2149). Die Daten wurden bivariat mittels Kreuztabelle und angeschlossenem χ2-Test ausgewertet. Die Auswertung des strukturierten Feedbacks erfolgte univariat mithilfe von prozentualen Häufigkeiten.

Ergebnisse
Durch die Intervention konnte keine signifikante Erhöhung der Treppennutzung festgestellt werden. Differenziert nach Geschlecht ließ sich bei Frauen im zweiten Beobachtungszeitpunkt eine signifikant höhere Treppennutzung von etwa 4 % beobachten (χ2[df = 1] = 5,361, p < 0,05). Während sich für die Altersgruppen keine signifikanten Unterschiede absichern ließen, fanden sich in Abhängigkeit des Beobachtungsorts nicht homogene Unterschiede der Treppennutzung. Die Feedbackgespräche wiesen für die Mehrheit der befragten Personen auf eine positive Bewertung der Nudging-Intervention.

Schlussfolgerung
Obgleich eine Verbesserung der Treppennutzung für die in dieser Studie beobachtete Gesamtpopulation nicht beobachtet werden konnte, liefern die Ergebnisse dennoch Hinweise für das Potenzial von Nudging-Interventionen zur Förderung eines insgesamt aktiveren Lebensstils. Künftige Interventionen sollten stärkere Sorgfalt auf die inhaltliche Gestaltung und das Design legen, geschlechtsspezifisch ausgerichtet sein und angemessene Evaluationsdesigns anwenden.
Kinetics of Transformation, Border of Metastable Miscibility Gap in Fe–Cr Alloy and Limit of Cr Solubility in Iron at 858 K
Authors: Dubiel S. M. , Żukrowski J. 
Published: May 2023

AbstractThe study was aimed at determination of the position of the Fe-rich border of the metastable miscibility gap (MMG) and of the solubility limit of Cr in iron at 858 K. Towards this end, a Fe73.7Cr26.3 alloy was isothermally annealed at 858 K in vacuum up to 8144 hours and Mössbauer spectra were recorded at room temperature after every step of the annealing. Three spectral parameters viz. the average hyperfine field, 〈B〉, the average isomer shift, 〈IS〉, and the probability of the atomic configuration with no Cr atoms in the two-shell vicinity of the probe Fe atoms, P(0,0), gave evidence that the transformation process took place in two stages. All three parameters could have been well described in terms of the Johnson–Mehl–Avrami–Kolmogorov equation, yielding kinetics parameters. The first stage, associated with the phase decomposition, proceeded much faster than the second stage, associated with the alpha-to-sigma phase transformation. The most reliable estimation of the position of the MMG and that of the value of the Cr solubility limit was obtained from the annealing time dependence of 〈B〉, namely 24.5 at. pct Cr for the former and 20.3 at. pct Cr for the latter. A comparison of these figures with the recent phase diagrams pertinent to Fe–Cr system was done.
A general class of shock models with dependent inter-arrival times
Authors: Goyal Dheeraj , Hazra Nil Kamal , Finkelstein Maxim 
Published: May 2023

AbstractWe introduce and study a general class of shock models with dependent inter-arrival times of shocks that occur according to the homogeneous Poisson generalized gamma process. A lifetime of a system affected by a shock process from this class is represented by the convolution of inter-arrival times of shocks. This class contains many popular shock models, namely the extreme shock model, the generalized extreme shock model, the run shock model, the generalized run shock model, specific mixed shock models, etc. For systems operating under shocks, we derive and discuss the main reliability characteristics (namely the survival function, the failure rate function, the mean residual lifetime function and the mean lifetime) and study relevant stochastic comparisons. Finally, we provide some numerical examples and illustrate our findings by the application that considers an optimal mission duration policy.
Structural insights into regulation of CCN protein activities and functions
Authors: Monsen Vivi Talstad , Attramadal Håvard 
Published: May 2023

AbstractCCN proteins play important functions during development, in repair mechanisms following tissue injury, as well as in pathophysiologic mechanisms of metastasis of cancer. CCNs are secreted proteins that have a multimodular structure and are categorized as matricellular proteins. Although the prevailing view is that CCN proteins regulate biologic processes by interacting with a wide array of other proteins in the microenvironment of the extracellular matrix, the molecular mechanisms of action of CCN proteins are still poorly understood. Not dissuading the current view, however, the recent appreciation that these proteins are signaling proteins in their own right and may even be considered preproproteins controlled by endopeptidases to release a C-terminal bioactive peptide has opened new avenues of research. Also, the recent resolution of the crystal structure of two of the domains of CCN3 have provided new knowledge with implications for the entire CCN family. These resolved structures in combination with structural predictions based upon the AlphaFold artificial intelligence tool provide means to shed new light on CCN functions in context of the notable literature in the field. CCN proteins have emerged as important therapeutic targets in several disease conditions, and clinical trials are currently ongoing. Thus, a review that critically discusses structure - function relationship of CCN proteins, in particular as it relates to interactions with other proteins in the extracellular milieu and on the cell surface, as well as to cell signaling activities of these proteins, is very timely.Graphical abstractSuggested mechanism for activation and inhibition of signaling by the CCN protein family (graphics generated withBioRender.com).
No (good) loss no gain: systematic evaluation of loss functions in deep learning-based side-channel analysis
Authors: Kerkhof Maikel , Wu Lichao , Perin Guilherme , Picek Stjepan 
Published: May 2023

AbstractDeep learning is a powerful direction for profiling side-channel analysis as it can break targets protected with countermeasures even with a relatively small number of attack traces. Still, it is necessary to conduct hyperparameter tuning to reach strong attack performance, which can be far from trivial. Besides many options stemming from the machine learning domain, recent years also brought neural network elements specially designed for side-channel analysis. The loss function, which calculates the error or loss between the actual and desired output, is one of the most important neural network elements. The resulting loss values guide the weights update associated with the connections between the neurons or filters of the deep learning neural network. Unfortunately, despite being a highly relevant hyperparameter, there are no systematic comparisons among different loss functions regarding their effectiveness in side-channel attacks. This work provides a detailed study of the efficiency of different loss functions in the SCA context. We evaluate five loss functions commonly used in machine learning and three loss functions specifically designed for SCA. Our results show that an SCA-specific loss function (called CER) performs very well and outperforms other loss functions in most evaluated settings. Still, categorical cross-entropy represents a good option, especially considering the variety of neural network architectures.
Crosstalk between long noncoding RNA and microRNA in Cancer
Authors: Bhattacharjee Rahul , Prabhakar Neeraj , Kumar Lamha , Bhattacharjee Arkadyuti , Kar Sulagna , Malik Sumira , Kumar Dhruv , Ruokolainen Janne , Negi Arvind , Jha Niraj Kumar , Kesari Kavindra Kumar 
Published: May 2023

AbstractmiRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management.
Graphic Abstract
Analysis of two thermoelastic problems with the Green–Lindsay model
Authors: Bazarra Noelia , Fernández José R. , Quintanilla Ramón 
Published: May 2023

AbstractIn this paper, we analyze, from the numerical point of view, two thermo-elastic problems involving the Green–Lindsay theory. The coupling term is different for each case, involving second order or first order spatial derivatives, respectively. The variational formulation leads to a linear coupled system which is written in terms of the velocity and temperature speed. An existence and uniqueness results and the exponential energy decay for the problem with the stronger coupling are recalled. The polynomial energy decay for the weaker coupling is then proved but using the theory of linear semigroups. Then, a fully discrete approximation is introduced using the finite element method and an implicit scheme. A discrete stability property and a main a priori error estimates result are shown, from which we can derive the linear convergence of the approximations. Finally, some numerical simulations are presented to demonstrate the accuracy of the algorithm, the discrete energy decay and the dependence on the relaxation parameter.
Biological Tissue-Inspired Ultrasoft, Ultrathin, and Mechanically Enhanced Microfiber Composite Hydrogel for Flexible Bioelectronics
Authors: Gao Qiang , Sun Fuqin , Li Yue , Li Lianhui , Liu Mengyuan , Wang Shuqi , Wang Yongfeng , Li Tie , Liu Lin , Feng Simin , Wang Xiaowei , Agarwal Seema , Zhang Ting 
Published: May 2023

AbstractHydrogels offer tissue-like softness, stretchability, fracture toughness, ionic conductivity, and compatibility with biological tissues, which make them promising candidates for fabricating flexible bioelectronics. A soft hydrogel film offers an ideal interface to directly bridge thin-film electronics with the soft tissues. However, it remains difficult to fabricate a soft hydrogel film with an ultrathin configuration and excellent mechanical strength. Here we report a biological tissue-inspired ultrasoft microfiber composite ultrathin (< 5 μm) hydrogel film, which is currently the thinnest hydrogel film as far as we know. The embedded microfibers endow the composite hydrogel with prominent mechanical strength (tensile stress ~ 6 MPa) and anti-tearing property. Moreover, our microfiber composite hydrogel offers the capability of tunable mechanical properties in a broad range, allowing for matching the modulus of most biological tissues and organs. The incorporation of glycerol and salt ions imparts the microfiber composite hydrogel with high ionic conductivity and prominent anti-dehydration behavior. Such microfiber composite hydrogels are promising for constructing attaching-type flexible bioelectronics to monitor biosignals.
Highly Efficient and Stable FAPbI3 Perovskite Solar Cells and Modules Based on Exposure of the (011) Facet
Authors: Zhang Kai , Ding Bin , Wang Chenyue , Shi Pengju , Zhang Xianfu , Liu Cheng , Yang Yi , Gao Xingyu , Wang Rui , Tao Li , Brooks Keith G. , Dai Songyuan , Dyson Paul J. , Nazeeruddin Mohammad Khaja , Ding Yong 
Published: May 2023

AbstractPerovskite crystal facets greatly impact the performance and stability of their corresponding photovoltaic devices. Compared to the (001) facet, the (011) facet yields better photoelectric properties, including higher conductivity and enhanced charge carrier mobility. Thus, achieving (011) facet-exposed films is a promising way to improve device performance. However, the growth of (011) facets is energetically unfavorable in FAPbI3 perovskites due to the influence of methylammonium chloride additive. Here, 1-butyl-4-methylpyridinium chloride ([4MBP]Cl) was used to expose (011) facets. The [4MBP]+ cation selectively decreases the surface energy of the (011) facet enabling the growth of the (011) plane. The [4MBP]+ cation causes the perovskite nuclei to rotate by 45° such that (011) crystal facets stack along the out-of-plane direction. The (011) facet has excellent charge transport properties and can achieve better-matched energy level alignment. In addition, [4MBP]Cl increases the activation energy barrier for ion migration, suppressing decomposition of the perovskite. As a result, a small-size device (0.06 cm2) and a module (29.0 cm2) based on exposure of the (011) facet achieved power conversion efficiencies of 25.24% and 21.12%, respectively.