bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Fabrication of Soft Prosthetic Hand
Authors: Ahmed Tanveer , Habibullah  , Shah Alishba , Soomro Abdul Qayoom , Soomro Afaque Manzoor , Randhawa Umar 
Published: January 2025

Abstract

This study focuses on the development of soft robotic hand designed to aid individuals with hand disabilities, particularly those paralyzed due to strokes. Globally, strokes affect 15 million people annually, leading to 5 million deaths and leaving another 5 million with permanent disabilities that significantly impact their lives and communities. The soft robotic hand developed attempts to addresses the limitations of traditional robotic hands through the use of PneuNets, a pneumatic network framework that mimics the structure and function of a human hand. The hand's design incorporates pneumatic chambers that enable controlled finger movements, essential for grasping, lifting, and manipulating objects with precision. The primary components of the hand were fabricated using additive manufacturing and molding techniques, with a silicone outer layer added to enhance safety and compliance. The microcontroller-based control system is tailored to execute desired actions effectively, ensuring the soft hand’s adaptability to various tasks. Performance evaluations involved both simple and complex task profiles, demonstrating the hand's capability to handle a variety of objects with low variability in force and high precision. Specific technical results include the measurement of grasping forces, pressure requirements for actuation, and the assessment of attenuation losses during operation. Prior designs of soft robotic hands often suffer from issues like single-mode gripping and high attenuation losses; our approach mitigates these challenges through an optimized mechanical design coupled with learning algorithms that enhance grasping and manipulation efficiency. The soft characteristics of the robotic hand allow it to adapt its shape, making it capable of handling objects of varying sizes and shapes, thereby improving the daily functionality for individuals with hand impairments. This novel design not only offers increased independence and quality of life for patients but also provides a cost-effective and easily producible solution for wearable soft robotics.
Causal Association between Arm Fat, Left Leg Fat, and Trunk Fat Masses and Risk of Polycystic Ovarian Syndrome: A Mendelian Randomization Study
Authors: Zhang Yuhan , Zhou Wei , Su Qiong , Chen Qi 
Published: January 2025

Background:
Observational studies have reported that arm fat, left leg fat, and trunk
fat masses have different effects on polycystic ovarian syndrome (PCOS). However, the causal
relationship between them remains unknown.

Materials and Methods:
A two-sample Mendelian randomization (MR) study was conducted by
utilizing pooled data from the largest Genome-Wide Association Study (GWAS). Random effect
inverse variance weighted (IVW) method, weighted median (WM), and MR-Egger regression
analysis were the main statistical methods utilized. Finally, a sensitivity assessment was
conducted. Cochran’s Q test was used to analyze heterogeneity, whereas MR-Egger regression
(intercept term) was used to analyze horizontal pleiotropy. The leave-one-out analysis was performed
to assess if MR estimates were impacted by a single nucleotide polymorphism (SNP)
exhibiting significant horizontal pleiotropy.

Results:
This study discovered a significant positive correlation between left leg fat mass, arm
fat mass, and trunk fat mass and genetic factors of PCOS (odds ratio (OR): 4.452, confidence
interval (CI): 2.740−7.232, p < 0.001, OR: 3.321, CI: 2.248−4.907, p < 0.001, and OR: 2.518,
CI: 1.722−3.682, p < 0.001, respectively).

Conclusion:
This study indicates that arm fat, left leg fat, and trunk fat masses may be genetically
correlated with PCOS.
miR-507 Acts as a Tumor Suppressor in Renal Cell Carcinoma Cells by Targeting STEAP3
Authors: Xiaobo Gong , Jian Huang , Linjie Guo , Zhe Tang , Guangjun Zhong , Ye Feng 
Published: January 2025

Introduction:
In recent years, there has been a rise in the incidence of renal cell carcinoma
(RCC), with metastatic RCC being a prevalent and significant contributor to mortality.
While a regulatory role for microRNAs (miRNAs) in the development and progression of RCC
has been recognized, their precise functions, molecular mechanisms, and potential clinical implications
remain inadequately elucidated. Hence, this study aimed to explore the role of miR-507
in RCC and identify STEAP3 as a downstream target of miR-507.

Introduction:
In recent years, there has been a rise in the incidence of renal cell carcinoma
(RCC), with metastatic RCC being a prevalent and significant contributor to mortality.
While a regulatory role for microRNAs (miRNAs) in the development and progression of RCC
has been recognized, their precise functions, molecular mechanisms, and potential clinical implications
remain inadequately elucidated. Hence, this study aimed to explore the role of miR-507
in RCC and identify STEAP3 as a downstream target of miR-507.

Introduction:
In recent years, there has been a rise in the incidence of renal cell carcinoma
(RCC), with metastatic RCC being a prevalent and significant contributor to mortality.
While a regulatory role for microRNAs (miRNAs) in the development and progression of RCC
has been recognized, their precise functions, molecular mechanisms, and potential clinical implications
remain inadequately elucidated. Hence, this study aimed to explore the role of miR-507
in RCC and identify STEAP3 as a downstream target of miR-507.

Methods:
Bioinformatics analysis was used to analyze the expression of miR-507 and STEAP3
in RCC specimens. CCK-8, Transwell, and flow cytometry assays were used to assess the function
of miR-507 in RCC cells. The connection between miR-507 and STEAP3 was confirmed
through a luciferase reporter assay. The expression level of STEAP3, p53, and xCT was analyzed
by western blotting.

Results:
Bioinformatics analysis showed that miR-507 was expressed at low levels in RCC tissues
and was linked to poor overall survival. STEAP3 was found to be significantly upregulated
in RCC. Further, STEAP3 was shown to be targeted by miR-507. High levels of miR-507 reduced
the expression of STEAP3, leading to stagnant cell viability, apoptosis, and migrative capacity.
Whereas miR-507 knockdown reverted such a tendency. The study also discovered that
miR-507 exerted its inhibitory effect through the op53/xCT pathway.

Conclusion:
Within RCC, miR-507 modulates the expression of SETAP3/p53/xCT axis, exhibiting
a tumor suppressive effect. These discoveries offer present prospective biomarkers for both
surveillance and treatment of RCC.

other:
N/A
Mechanisms Underlying the Anti-Atherosclerotic Effects of EGCG
Authors: Wang Lili , Tang Chunlian , Pan Qun 
Published: January 2025

Abstract:
Atherosclerosis (AS) is a chronic inflammatory vascular disease and the
primary pathological basis of cardiovascular diseases. Epigallocatechin-3-gallate
(EGCG), the most abundant polyphenol compound in green tea, has garnered
significant attention in recent years for its protective effects against AS. EGCG
possesses properties that lower lipid levels, exhibit antioxidant and anti-inflammatory
activities, enhance plaque stability, and promote the recovery of endothelial function.
The regulatory mechanisms of EGCG in AS primarily involve inhibiting apoptosis,
modulating autophagy, improving gut microbiota, and regulating the Nrf2 and
inflammatory signaling pathways. This review summarizes the role of EGCG in the
prevention and treatment of AS and its potential mechanisms, providing a scientific
basis for future research directions and therapeutic applications.
Isoindoline-1,3-dione Derivatives as Prototypes for Anticonvulsant Drug Discovery
Authors: Chelucci Rafael Consolin , Chiquetto Richard , Chiba Diego Eidy , Scarim Cauê Benito , Chin Chung Man , Dos Santos Jean Leandro 
Published: January 2025

Introduction:
Epilepsy encompasses numerous syndromes characterized by spontaneous,
intermittent, and abnormal electrical activity in the brain. Affecting about 1-2% of the population,
it is estimated that approximately 30-40% of patients experience refractory epilepsy, which
does not respond to traditional anticonvulsant drugs.

Aims:
Therefore, developing novel, safe, and effective antiepileptic drugs remains a medical need.
In this study, we synthesized a series of isoindoline-1,3-dione derivatives and evaluated their anticonvulsant
effects.

Results:
Compounds (2a-j) and (5) were obtained with yields ranging from 52-97%. These compounds
were assessed for their protective effects on the following parameters: a) time to first seizure
(seizure latency), b) seizure duration, and c) mortality rate post-seizure. The most active
compound, (2a), increased seizure latency, reduced seizure duration, and lowered the mortality
rate.

Conclusion:
These findings indicate that compound (2a) is a promising new anticonvulsant prototype,
offering an alternative to current anticonvulsant drugs.
Royal Jelly's Strong Selective Cytotoxicity Against Lung Malignant Cells and Macromolecular Alterations in Cells Observed by FTIR Spectroscopy
Authors: Aysin ferhunde 
Published: January 2025

Introduction/Objective:
Several nutraceuticals, food, and cosmetic products can be developed using
royal jelly. It is known for its potential health benefits, including its ability to boost the immune system and reduce
inflammation. It is rich in vitamins, minerals, and antioxidants, which can improve general health. Royal
jelly (RJ) is also being studied as a potential therapeutic agent for cancer and other chronic diseases. It is effective
in reducing tumor growth and stimulating immunity.

Methods:
In this study, we investigated the effects of royal jelly on cancerous A549 cells and healthy MRC-5
cells at various doses ranging from 1.25 to 10 mg/ml. Royal jelly's anti-proliferative effect was evaluated by MTT
and SRB assay for 48 h. The induction of necrosis and apoptosis was assessed by flow cytometry as well. The
relative amounts of major molecules in Royal jelly were determined by FTIR spectroscopy to identify key functional
groups and molecular structures. In addition, this technique was used for the first time to detect changes in
the macromolecular composition of lung cells treated with royal jelly. Thus, it provided insights into the relative
abundance of proteins, lipids, and carbohydrates, which could correlate with their bioactive properties.

Results:
The antiproliferative effect of Royal jelly was found to be selective on A549 cells in a dose-dependent
manner with an IC50 of 9.26 mg/mL, with no cytotoxic effects on normal MRC-5 cells. Moreover, Royal jelly
induced predominantly necrotic cell death in A549 cells, %39.10 at 4 mg/ml and %57.88 at 10 mg/ml concentrations.
However, the necrosis rate in MRC-5 cells was quite low, at 9.16% and 20.44% at the same doses. Royal
jelly showed dose-dependent selective cytotoxicity toward A549 cells, whereas it exhibited no apparent cytotoxicity
in MRC-5 cells. In order to identify the biomolecular changes induced by royal jelly, we used two unsupervised
chemometric pattern recognition algorithms (PCA and HCA) on the preprocessed sample FTIR spectra to
determine the effects of royal jelly on cell biochemistry. According to PCA and HCA results, RJ treatments especially
affected biomolecules in A549 cells. The total spectral band variances in the PCA loading spectra were
calculated for understanding biomolecular alterations. These plots revealed profound changes in the lipid, protein,
and nucleic acid content of RJ-applied lung cells, primarily identifying RJ and H2O2 treated groups for A549
cells.

Conclusion:
Ultimately, the selective cytotoxicity of royal jelly toward A549 cancerous cells suggests that royal
jelly may be a promising therapeutic agent for identifying innovative lung cancer treatment strategies. Additionally,
understanding the molecular alterations induced by royal jelly could guide the development of novel cancer
treatments that exploit its bioactive properties. This could lead to more effective and safer therapies.
Plasma Hepatic Transaminases and Incidence of Metabolic Syndrome Before Midlife in Military Adults: A CHIEF Cohort Study
Authors: Liu Fang-Chen , Chen Kai-Wen , Tsai Kun-Zhe , Chu Chen-Chih , Lin Yen-Chen , Chang Yun-Chen , Lin Gen-Min 
Published: January 2025

Background:
Plasma AST and ALT may reflect the nonalcoholic fatty liver disease
(NAFLD) severity and have been associated with the risk of MetS in middle- or old-aged individuals.

Aims:
This study aimed to examine the associations of plasma hepatic aspartate and alanine transaminases
(AST and ALT) levels with incident metabolic syndrome (MetS) in young adults,
which have not been verified before.

Objective:
The goal of this study was to identify the association between plasma hepatic transaminases
and the incidence of new-onset MetS among young adults.

Methods:
There were 2,804 military men and women, with ages of 18-39 years, free of baseline
MetS and any viral hepatitis in Taiwan in 2014. Incident MetS were followed in the annual military
health examinations from baseline till the end of 2020. The definition of MetS was made using
the criteria of the International Diabetes Federation. Plasma concentrations of AST and ALT
were checked at baseline. A Multivariable Cox regression model with adjustments for sex, age,
each component of MetS, body mass index, substance use status, and physical activity at baseline
was performed to determine the associations. Subgroup analyses were performed according to sex
and each MetS component.

Results:
During a median follow-up of 5.8 years, 644 incident MetS (23.0%) developed. ALT and
AST levels (each 10 U/L increase) were respectively associated with 5% and 11% increased risk
of incidence of MetS (hazard ratios (HRs) and 95% confidence intervals (CIs): 1.05 (1.01-1.09)
and 1.11 (1.04-1.19), respectively). In subgroup analyses, the risk of incidence of MetS with ALT
and AST levels respectively increased 75% and 114% in women (HRs: 1.75 (1.07-2.87) and 2.14
(1.35-3.41), respectively), and 7% and 14% in those free of central obesity (HRs: 1.07 (1.02-1.11)
and 1.14 (1.06-1.23), respectively) which were higher than their counterparts (p-values for interaction
by sex: 0.06 and 0.001, respectively; and by central obesity: 0.04 and 0.07, respectively).

Conclusion:
Plasma hepatic transaminase levels were positively associated with incident MetS
among young adults. The individual role of central obesity and sex on the association of ALT and
AST with incident MetS should be further clarified.
Evaluation of the Performance of Concrete Reinforced with Bamboo and Incorporating Cassava Peel Ash
Authors: Awolusi Temitope Funmilayo , James Aladegboye Oluwasegun , Emmanuel Babalola Olusola , Abdallah Mirvat , Abu James Gana , Kunle Ayo Emmanuel , Azab Marc 
Published: January 2025

Introduction
The main materials utilized in the production of reinforced concrete are aggregates, cement, and steel. The production of steel and cement contributes to the generation of carbon dioxide emissions, which is a main cause of global warming.

Methods
To further enhance sustainability in the construction industry, this study focuses on utilizing alternative sustainable materials in bamboo-reinforced concrete containing cassava peel ash (BRC-CPA) by fully replacing steel with bamboo strips and partially replacing cement with cassava peel ash. The experimental phase includes material characterization for the cassava peel ash (CPA) and bamboo reinforcements. Eighty-nine samples of BRC-CPA beams with dimensions 100×150×500 mm were produced, and bamboo strips of three different sizes, 12, 14, and 16 mm, were prepared and used as reinforcement in the BRC-CPA beams to evaluate their flexural strength and flexural strain. In addition, 12 samples of 150 mm cassava peel ash-blended concrete (CPAC) cubes without bamboo strips were produced. The cassava peel ash was used to partially replace cement at three levels, 0, 10, and 20%, to evaluate their influence on the compressive strength and water absorption of concrete cube samples.

Results
The addition of CPA slightly reduced the compressive strength of CPAC cubes, with values of 23.4 N/mm², 22.2 N/mm², and 21.4 N/mm² observed for 0%, 10%, and 20% CPA replacement levels, respectively. However, incorporating CPA had a positive effect by reducing water absorption and narrowing the flexural crack width in BRC-CPA beams. The flexural strength of BRC-CPA beams increased as the concrete aged, but decreased as the bamboo reinforcement size increased. Notably, at 20% CPA replacement, the flexural strength was less influenced by the bamboo strip size compared to beams with 0% CPA.

Conclusion
Based on experimental results obtained for compressive strength, flexural strength, and flexural crack width, cassava peel ash at 10% replacement and bamboo strips of size 14 mm were recommended for use in BRC-CPA for concrete structural elements such as beams, columns, and slabs.
The Impact of Linguistic Signals on Cognitive Change in Support Seekers in Online Mental Health Communities: Text Analysis and Empirical Study
Authors: Li Min , Gu Dongxiao , Li Rui , Gu Yadi , Liu Hu , Su Kaixiang , Wang Xiaoyu , Zhang Gongrang 
Published: January 2025

Background
In online mental health communities, the interactions among members can significantly reduce their psychological distress and enhance their mental well-being. The overall quality of support from others varies due to differences in people’s capacities to help others. This results in some support seekers’ needs being met, while others remain unresolved.

Objective
This study aimed to examine which characteristics of the comments posted to provide support can make support seekers feel better (ie, result in cognitive change).

Methods
We used signaling theory to model the factors affecting cognitive change and used consulting strategies from the offline, face-to-face psychological counseling process to construct 6 characteristics: intimacy, emotional polarity, the use of first-person words, the use of future-tense words, specificity, and language style. Through text mining and natural language processing (NLP) technology, we identified linguistic features in online text and conducted an empirical analysis using 12,868 online mental health support reply data items from Zhihu to verify the effectiveness of those features.

Results
The findings showed that support comments are more likely to alter support seekers’ cognitive processes if those comments have lower intimacy (βintimacy=–1.706, P<.001), higher positive emotional polarity (βemotional_polarity=.890, P<.001), lower specificity (βspecificity=–.018, P<.001), more first-person words (βfirst-person=.120, P<.001), more future- and present-tense words (βfuture-words=.301, P<.001), and fewer function words (βlinguistic_style=–.838, P<.001). The result is consistent with psychotherapists’ psychotherapeutic strategy in offline counseling scenarios.

Conclusions
Our research contributes to both theory and practice by proposing a model to reveal the factors that make support seekers feel better. The findings have significance for support providers. Additionally, our study offers pointers for managing and designing online communities for mental health.
Gobierno y disciplina en las parroquias del arzobispado de México después del Tercer Concilio Mexicano (1585-1630)
Authors: Aguirre Salvador Rodolfo 
Published: January 2025

Este artículo desea aportar nuevos elementos para el estudio de la reforma católica y del real patronato en las parroquias, especialmente en sus aspectos disciplinarios. Se analizan algunas problemáticas posteriores al Tercer Concilio Mexicano de 1585. La investigación se fundamenta en expedientes del antiguo archivo del arzobispado de México poco conocidos. El primer objetivo es analizar el papel de la mitra para impulsar la normativa conciliar y monárquica. El segundo es estudiar la intervención de los virreyes y de la Real Audiencia en las controversias y los pleitos de las parroquias. El tercero es explorar las relaciones entre párrocos y feligreses en tres aspectos: el desempeño de los sacerdotes, las problemáticas de la administración parroquial y el nuevo régimen de derechos parroquiales.
Luto, fiesta primera: cambios socioculturales de las celebraciones funerarias en Chiapas entre los siglos XVI y XIX
Authors: Bermúdez Hernández Luz del Rocio 
Published: January 2025

El ceremonial luctuoso de los siglos XVI-XIX fue una fiesta mayor que contrasta con la evocación actual del término: alegre, jocosa e irreverente. Fuentes documentales sobre Chiapas —estado mexicano entonces vinculado al Virreinato de Nueva España y a la Capitanía General de Guatemala— mostrarán la centralidad y solemnidad de las obsequias en el despliegue ceremonial, y además como dispositivo de control y jurarquización sociocultural. Algunos aspectos relacionados son las exequias de privilegio y los entierros del común; incriminaciones a velorios urbanos —incluso de élites— y a festividades populares —particularmente indígenas—, y la mutación de la religiosidad implicada en el cambio del Día de Todos los Santos y Fieles Difuntos por el “Día de Muertos” turístico-comercial del México de hoy.
¿Por quién redoblan las campanas? Fiesta y tragedia: las campanas y su papel simbólico en los conflictos de independencia en España y América (1808-1825)
Authors: Cuño Bonito Justo 
Published: January 2025

En las sociedades del siglo XIX, no solo se representaba y reconocía lo que era visto, sino también lo que se escuchaba, y el tañido, repique, toque a rebato, doble o redoble, convocaban, prevenían, retraían o acompañaban tanto la alegría como la tristeza de todo el cuerpo social. El objetivo del artículo es comprender de qué manera los diferentes actores en conflicto adoptaron patrones simbólicos fácilmente reconocibles por la población para ganarse su apoyo y movilizarla a favor de la causa propia o en contra de la causa de los adversarios. Metodológicamente, se adopta un enfoque hermenéutico-interpretativo, basado en la comprensión y exégesis de fuentes primarias vinculadas al desarrollo investigativo. Se analizan las fuentes en busca de esa significación de los actos humanos que explica la resignificación simbólica de la campana en los conflictos de independencia en la Península y en América. Los resultados alcanzados establecen que las festividades religiosas, de gremio o barriales estaban planificadas y perfectamente estructuradas, a diferencia de las celebraciones posteriores a una batalla, que respondían más a una estudiada improvisación en la cual, eso sí, siempre quedaba claro el nuevo/viejo orden social.