bluuebunny/crossref_metadata_2025_split huggingface dataset:
Degradation and bioconversion of complex municipal solid waste streams into human biotherapeutics and biopolymers
Authors: Gonzalez Guadalupe Alvarez , Chacόn Micaela , Berepiki Adokiye , Fisher Karl , Dixon Neil 
Published: March 2023

Abstract
Linear consumption models in combination with the poor waste management results in negative impact upon the climate and environment. Here we show an advanced biorefinery concept to produce biopolymers and recombinant therapeutic proteins from municipal solid waste. Careful selection and metabolic engineering of Pseudomonas putida was employed to permit efficient co-utilisation of complex, heterogenous substrate compositions derived from the most abundant municipal solid waste fractions. Enzymatic pre-treatment of the feedstock was performed, which afforded sufficient carbon for growth and bio-production of value-added products. Unlike current waste processing methods and supply of feedstocks for bio-based manufacturing, this biorefinery concept re-directs the carbon away from direct emissions and creates a land-use negative feedstock ideal for advanced biomanufacturing. We envisage this demonstration will lead to the creation of circular consumption solutions for waste and bio-production of a range of chemicals and materials in future resource finite scenarios.
Efficacy of Gaseous Ozone Therapy as an adjuvant to Periodontal Treatment on Oxidative Stress Mediators in Patients with Type 2 Diabetes: A Randomized Clinical Trial
Authors: Rapone Biagio , Ferrara Elisabetta , Qorri Erda , Inchingolo Francesco , Isola Gaetano , Dongiovanni Paola , Tartaglia Gianluca Martino , Scarano Antonio 
Published: March 2023

Abstract
Background

Chronic inflammation and cumulative oxidative stress have been theorized as two common pathways of the interconnection between periodontitis and diabetes. Improvement in oxidizing status has been demonstrated in periodontal patients with diabetes treated with proper non-surgical periodontal treatment. In addition to periodontal treatment, Gaseous ozone therapy has been reported to possess anti-inflammatory properties and the ability to stimulate the endogenous antioxidant defence mechanism. To date, the antioxidant effect of gaseous ozone, in addition with periodontal treatment in diabetic patients, has been examined in only one study. The aim of this study was to determine the efficacy of gaseous ozone therapy as an alternative approach to supporting non-surgical periodontal therapy (NSPT), aimed at improving antioxidant machinery and interfering with ROS production on plasma levels in diabetic individuals diagnosed with moderate or severe periodontitis.

Methods

One hundred and eighty patients with periodontitis and type 2 diabetes mellitus were randomly assigned to receive non-surgical periodontal treatment (NSPT) plus gaseous ozone therapy (A) NSPT alone (B). Clinical and periodontal parameters and plasma levels of oxidant-antioxidant (TOS-TAS) levels, glutathione (GSH), and malondialdehyde (MDA) were recorded at baseline and at 3- (T1) and at 6-months (T2) after treatment.

Results

Both treatments were efficacious in reducing clinical parameters. However, there were no significant differences regarding oxidative stress parameters in group A compared to group B, and the levels of TOS and TAS (p > 0.001) were registered.

Conclusions

In the present study, gaseous ozone therapy did not enhance the effect of periodontal treatment in reducing oxidative stress in plasma levels of periodontitis patients with type II diabetes.
Trial registration: The study was registered with ISRCTN1728169 (23/07/2022).
Impact of Covid-19 pandemic on the management of gynaecological cancer: a Spanish survey.
Authors: Gracia Myriam , Rodríguez Elena , Diestro María Dolores , Spagnolo Emanuela , García Virginia , Siegrist Jaime , Pérez Yolanda , Zapardiel Ignacio , Hernández Alicia 
Published: March 2023

Abstract
Background: During the SARS-cov2 pandemic, to evaluate if the clinical protocols in gynecology oncology assistance were changed and, to assess the perception for the management of these disease in the surgeon.
Methods: The data were collected by an anonymous and voluntary survey which was sent via email to professionals dedicated to the field of gynaecological oncology in Spain.
Results: A total of 75 professionals completed the online survey, 93.2% reported working in a public hospital and 62.5% in a tertiary level hospital. 97.3% belonged to hospitals treating patients with SARS-CoV2 infection. An 85.1% of respondents showed concern about the SARS-CoV2 pandemic and 52.1% indicated the pandemic influenced the diagnostic and therapeutic quality of oncologic patients. SARS-CoV2 PCR on nasopharyngeal exudate was always performed before surgical interventions by 97.3%, being considered best triage method by 94.4%. An 87.5% reported no change in the type of surgical approach during the pandemic. Limitations in accessing special protective equipment against SARS-CoV2 were found by 62.5%. An impact on the follow-up of patients with gynaecological cancers due to pandemic was referred by a 70.4%.
Conclusions: Most of Spanish gynecologist oncologist reported that COVD 19 pandemic has affected their clinical practice. The major measures implemented were an increase of telemedicine, a decrease the visits to high-risk or symptomatic patients and the use of SARS-CoV2 screening prior to surgery.
The effect of combined training and resveratrol supplementation on serum levels of adropin, vascular endothelial growth factor, nitric oxide, and gene expression of fibroblast growth factor-2 and angiostatin in myocardial infarction rats
Authors: Ghasemi Fatemeh , Namjoo Mohadeseh , ashabi Fatemeh , Niknejad Negin , Ebrahimi Mohammadamin , Khatib Ali , Tezerji Sajjad , Moradabadi Mohammad Moradiani 
Published: March 2023

Abstract
Objectives: The aim of current study was evaluating the effect of exercise training and resveratrol supplementation on serum levels of adropin, vascular endothelial growth factor (VEGF), nitric oxide (NO), and gene expression of angiostatin and fibroblast growth factor-2 (FGF-2) in myocardial infarction rats
Methods: 40 male Wistar rats four weeks after cardiac infarction were randomly divided into four groups: 1: control group (C-MI, n=10) 2: resveratrol group (Res-MI, n=10) 3: exercise group (Ex+MI, n=10) and 4: exercise group with resveratrol supplement (Ex+Res, n=10) were divided. The Ex+MI group and the Ex+Res group performed running on a treadmill for 10 weeks (5 sessions per week and each session lasting 50 minutes at a speed of 17 meters per minute). The serum levels of adropin, VEGF and NO were measured by ELISA method and expression of angiostatin and FGF-2 genes were measured by Real Time-PCR. The statistical analysis of the obtained data was done using the one-way analysis of variance test.
Results: The findings of the present study showed that the level of NO, VEGF and adropin in EX+Res, Ex+MI and Res+Mi groups were significantly different from C-MI. Also, the difference between Ex+Res and other groups was significant. In terms of gene expression, the highest expression of FGF-2 was in the Ex+Res group and then in the Ex+MI group, and there was a significant difference between the level of Ex+Res and the Res-MI group. Also, the lowest angiotensin gene expression was in the Ex+Res and Ex+MI groups, which showed a significant difference compared to the other two groups.
Conclusion: Ten weeks of aerobic exercise training and resveratrol supplementation lead to increase the levels of VEGF, adropin, NO as well as the mRNA expression of FGF-2 and decrease the levels of angiostatin in MI rat’s model.
The effect of simultaneous intravitreal Ranibizumab and intravitreal extended-release dexamethasone injection on patients with naïve versus refractory retinal vein occlusion macular edema: prospective, single-center, interventional, and open-label study
Authors: Sun Yaoyao , Meng Jie , Li Shanshan , Zhao Mingwei , Qi Huijun 
Published: March 2023

Abstract
Background

The efficacy of concurrent intravitreal Ranibizumab (IVR) and extended-release dexamethasone injections (Dex-I) in patients with naïve and refractory retinal vein occlusion macular edema (RVO-ME) was not well investigated previously.

Methods

This was a prospective, interventional, and open-label case series design. There were two groups: naïve and refractory patients (received ≥ 5 times of previous IVR within one year prior to enrollment) enrolled. Patients received IVR and Dex-I concurrently. IVR and Dex-I were given PRN. The mean change in best-corrected visual acuity (BCVA) was measured as main outcome.

Results

63 patients (63 eyes) completed the entire follow-up (31 naïve and 32 refractory patients). At month 12, the change in BCVA was greater in the naïve group than in the refractory group (19.67 ± 11.7 (95%CI: 15.03,24.31) letters vs. 11.74 ± 11.18 (95%CI:7.32,16.16) letters, P = 0.014). There was no difference between the two groups of mean macular thickness reduction. (364.26 ± 215.29 (95%CI: 279.09,449.43)µm v.s. 410.19 ± 204.34 (95%CI: 329.35,491.02)µm, P = 0.43). The mean co-injection numbers were 2.52 ± 0.58 (95%CI:2.29,2.75) and 2.33 ± 0.55(95%CI:2.11,2.55) in both groups (P = 0.24). The retreatment interval was 115.81 ± 13.79 (95%CI: 110.36,121.27) days and 122.74 ± 14.06(95%CI: 119.93,133.56) days in both groups (P = 0.073). There was no significant difference in the incidence of glaucoma or the progression of cataracts between the two groups.

Conclusion

In both naïve and refractory RVO-ME patients, IVR combined with Dex-I was effective. The initial combination therapy for naïve patients demonstrated more efficient improvement in BCVA and may reduce total injection numbers.
Trial registration: this study was registered with the identifier ChiCTR-INR-17011877 at https://www.chictr.org.cn/
Survey of Australian primary eyecare management of choroidal naevus patients
Authors: Trang Thi Minh , Tang Erin , Challinor Kirsten , Jalbert Isabelle , Madigan Michele , Conway R. Max 
Published: March 2023

Abstract
Background: Choroidal naevus is a benign, relatively common ocular tumour. Discerning common naevi from rare primary eye melanoma and managing these patients using an evidence-based approach remains an ongoing clinical challenge. We surveyed primary eyecare practitioners on their current management and use of imaging for choroidal naevus patients.
Methods: A random sample of 1,130 optometrists and ophthalmologists registered to practice in Australia were surveyed using a purpose-designed questionnaire containing demographics, imaging techniques used, and knowledge (K), attitude (A), and practice (P) questions.
Results: 93 optometrists and 82 ophthalmologists responded. More than 50% practised independently, most in metropolitan centres (n=113/175). Imaging techniques were often used to detect and monitor choroidal naevus, with 72% of practitioners using optical coherence tomography and colour fundus photography. KAP scores indicated moderate knowledge (mean=5.2/9, SD=1.8). Recent mnemonics for risk of naevus-to-melanoma transformation were underutilised being used by less than 50% of practitioners. Scores indicated very positive attitude (mean=6.5/8, SD=1.2) but moderate practice (mean=13.9/25, SD=2.9) in this area. A significant difference between optometrists and ophthalmologists was found for knowledge, but not attitude or practice scores. Choroid naevus patients were referred to a specialist ophthalmologist by a third of all practitioners.
Conclusion: Many eyecare practitioners utilised several imaging techniques to detect and monitor choroidal naevi. Gaps in knowledge were found associated with choroidal naevus growth. Findings align with recent studies highlighting eyecare pathways for choroidal naevus patients that provide diligent screening and review, timely referral for signs of potential melanoma-related risk, and that encourage multi-disciplinary care.
Complications of Preventive Loop Ileostomy versus Colostomy: A Meta-Analysis, Trial Sequential Analysis, and Systematic Review
Authors: Ge Zheng , Zhao Xiang , Liu Zitian , Yang Guangwei , Wu Qunzheng , Wang Xiaoyang , Zhang Xiang , Cheng Zhiqiang , Wang Kexin 
Published: March 2023

Abstract
Background

Preventive colostomy is required for colorectal surgery, and the incidence of complications associated with ileostomy and colostomy remains controversial. This study aimed to compare the incidence of postoperative complications between ileostomy and colostomy procedures.

Methods

Data analysis was conducted on 30 studies, and meta-analysis and trial sequential analysis (TSA) were performed on five studies. The basic indicators, such as stoma prolapse, leak, wound infection, ileus, and a series of other indicators, were compared.

Results

No statistically significant differences were observed with complications other than stoma prolapse. Meta-analysis and TSA showed that the incidence of ileostomy prolapse was lower than that of colostomy prolapse, and the difference was statistically significant. Apart from the four complications listed above, the general data analysis showed differences in incidence between the two groups. The incidence of skin irritation, parastomal hernia, dehydration, pneumonia, and urinary tract infections was higher with ileostomy than with colostomy. In contrast, the incidence of parastomal fistula, stenosis, hemorrhage, and enterocutaneous fistula was higher with colostomy than with ileostomy.

Conclusions

There were differences in the incidence of ileostomy and colostomy complications in the selected studies, with a low incidence of ileostomy prolapse.
PROSPERO registration number: CRD42022303133
Exploring the Acceptance and Perceptions of Herbal Medicine among the General Public in Pakistan: A Societal Perspective
Authors: Khan Soha , Khan Roha , Osama Muhammad , Muhammad Iyad Naeem , Iqbal Sarmad 
Published: March 2023

Abstract

Background:Herbal medicine has been widely used as an alternative or complementary form of treatment in many countries, including Pakistan.The objective of this study was to assess the perception and usage of herbal medicine among the general population of Pakistan with different educational backgrounds.Method:An online descriptive cross-sectional study was conducted from 1st January 2023 to 15th January 2023 through electronic media channels. A self-administered semi-structured questionnaire was used to gauge the most common disorders occurring in the population and the most common herbal medicines used by the population.Results:Out of 273 participants, 43.75% were male and 56.25% were female, with 78% belonging to the age group of 18-29 Years. Over 60% of the respondents have used herbal medicines in the last 6 months, with most of them using herbal medicine for 1 week. The most common source of medical information was from family and internet sources. Nearly half of the participants did not feel the need to inform their physician regarding their usage of herbal medicine, and most of the population perceived that herbal medicines are safer and more economical compared to pharmaceutical medicines.Conclusion:The study results showed that the population of Pakistan has a neutral to positive perception of herbal medicine, with most of them believing that herbal medicines are safe, economical, and have a beneficial effect on their health. Further research is needed to assess the safety and efficacy of herbal medicine in the population of Pakistan.
The Educational Value of ward rounds as learning and teaching opportunity for Medical students at sinnar university faculty of medicine
Authors: alteib mogahid alteib yousif , Ahmed Fadi M. Toum , MOHAMMED AHMED BABIKER ELTAYP , BALLA SAMER MOHAMMED AHMED , DIAB DANIA ABDALLA HASSAN , SAIFALDEEN MONZER MOHAMMED ALMAHDI ALI , FADLALLAH KHALID ALI MUSTAFA , ELDAI YASIR AHMED ISMAIL , MOHAMMED OSMAN ASIM BABKER , BALLA ESRAA MOHAMMED AHMED , MOHAMEDELNOUR MOHAMED ELBADAWI ELSHAIKH , ELTERAIFI AYA MORTADA AWADELKARIM , SULIMAN AHMED ALMAHI MOHAMED , BALLA AHMED MOHAMMED AHMED , AHMED ELBASIL NASERELDIN YOUSIF 
Published: March 2023

Abstract
Since they were first recorded in 1660, ward rounds have been a useful resource for medical education for both students and teachers. It has become vital to continue making efforts to enhance the educational value of ward rounds as a result of the deployment of innovative educational methodologies over the past several years, such as the clinical skills lab, small group vacillated session, and problem-based learning. The Sudan has never carried out a research of this nature before. As medical students at Sinnar University strive to do better, it also offers a framework for productive rounds and common difficulties they encounter. To gather information from all medical students who have attended rounds, a survey was done utilizing a Google form. Ninety-three percent of medical students strongly agree or agree that "ward rounds have been an excellent chance for clinical examination, ninety-one present for history collection." The biggest challenges are a lack of time and the ward atmosphere. The most crucial elements of a good round When it comes to physicians, students choose a professor who is enthusiastic about teaching, gives them the chance to practice, lets them interact with patients, asks good questions, and provides adequate feedback. Word-round contuse could serve as a crucial instrument in medical education.
Self-reported versus administrative data records: implications for assessing healthcare resource utilization of mental disorders
Authors: Garcia Tarcyane Barata , Kliemt Roman , Claus Franziska , Neumann Anne , Soltmann Bettina , Baum Fabian , Schwarz Julian , Swart Enno , Schmitt Jochen , Pfennig Andrea , Häckl Dennis , Weinhold Ines 
Published: March 2023

Abstract
Background: Data on resourceuse are frequently required for health economic evaluation. Studies on health care utilization in individuals with mental disorders have analyzed both self-reports and administrative data, each of which with strengths and limitations. Source of data may affect the quality of cost analysis and compromise the accuracy of results. We sought to ascertain the degree of agreement between self-reports and statutory health insurance (SHI) fund claims data from patients with mental disorders to aid in the selection of data collection methods.
Methods:Claims data from six German SHI and self-reported data were obtained along with a cost-effectiveness analysis performed as a part of a controlled prospective multicenter cohort study conducted in 18 psychiatric hospitals in Germany (PsychCare), including patients with pre-defined common and/or severe psychiatric disorders. Self-reported data were collected using the German adaption of the Client Sociodemographic and Service Receipt Inventory (CSSRI-D) questionnaire with a 6-month recall period. Data linkage was performed using a unique pseudonymized identifier. Healthcare utilization (HCU) was calculated for inpatient and outpatient care, day-care services, home treatment, and pharmaceuticals. Concordance was measured using Cohen’s Kappa and intraclass correlation coefficient. Regression approaches were used to investigate the effect of independent variables on the dichotomous and quantitative agreements.
Results: In total 274 participants (mean age 47.8 [SD = 14.2] years; 47.08% women) were included in the analysis. Kappa values were 0.03 for outpatient contacts, 0.25 for medication use, 0.56 for inpatient days and 0.67 for day-care services. There was varied quantitative agreement between data sources, with the poorest agreement for outpatient care (ICC [95% CI] = 0.22 [0.10-0.33]) and the best for psychiatric day-care services (ICC [95% CI] = 0.72 [0.66-0.78]). Marital status and time since first treatment positively affected the chance of agreement on any use of outpatient services.
Conclusions: Concordance between administrative records and patient self-reports was fair to moderate for most of the healthcare services analyzed. Health economic studies should consider using linked or at least different data sources to estimate HCU or focus the primary data-based surveys in specific utilization areas, where unbiased information can be expected.
[MoS] Insertion Chains Induced Small-Polaron Collapse in MoS2 2D Layers: A Novel Mo2S3 Anode for Ultrafast Sodium Storage
Authors: Lv Zhuoran , Zhao Chendong , Xie Miao , Cai Mingzhi , Peng Baixin , Ren Dayong , Fang Yuqiang , Dong Wujie , Zhao Wei , Lin Tianquan , Lv Ximeng , Zheng Gengfeng , Huang Fuqiang 
Published: March 2023

Abstract
Molybdenum disulfide (MoS2) with high theoretical capacity has been viewed as a promising anode for sodium-ion batteries, but suffers from inferior rate capability owing to the polaron-induced slow charge transfer. Herein, we proposed a polaron collapse strategy induced by electron-rich insertions to effectively solve the above issue. Specifically, 1D [MoS] chains are inserted into MoS2 to break the symmetry states of 2D layers and induce small-polaron collapse to gain fast charge transfer, so that the as-obtained thermodynamically stable Mo2S3 shows metallic behavior with 107 times larger electrical conductivity than that of MoS2. Theoretical calculations demonstrate that Mo2S3 owns highly delocalized anions, which substantially reduces the interactions of Na − S to efficiently accelerate Na+ diffusion, endowing Mo2S3 lower energy barrier (0.38 vs 0.65 eV of MoS2). The novel Mo2S3 anode exhibits a high capacity of 510 mAh g− 1 at 0.5 C and a superior high-rate stability of 217 mAh g− 1 at 40 C over 15000 cycles. Further in situ and ex situ characterizations reveal the in-depth reversible redox chemistry in Mo2S3. The proposed polaron collapse strategy for intrinsically facilitating charge transfer could be conducive to electrode design for fast-charging batteries.
An improved multi-source information fusion method for IMU compensation of missile
Authors: Shi Chunfeng , Chen Xiyuan , Wang Junwei 
Published: March 2023

Abstract
The conventional SINS/CNS integrated navigation system equipped on ballistic missiles is typically equipped with attitude measurement, which can only effectively estimate the gyro drift and has no effect on accelerometer bias. To address the issue, an improved multi-source information fusion method containing a new nonlinear framework called SINS/RKCNS with the indirect horizon reference and kinematic constraint is proposed, and a MAP-based modified iterated CKF (MICKF) is involved to increase positioning accuracy and system robustness. Furthermore, to eliminate the influence of correlated noise, state augmentation is employed in the iterative process. Eventually, experiments are conducted to evaluate ballistic missile performance. The results confirm the effectiveness of the proposed approach.
A Novel Robust Iterated CKF for GNSS/SINS Integrated Navigation Applications
Authors: Wang Junwei , Chen Xiyuan , Shi Chunfeng 
Published: March 2023

Abstract
In challenging circumstances, the estimation performance of integrated navigation parameters for tightly coupled GNSS/SINS is impacted by outlier measurements. An effective solution that employs a novel iterative sigma-point structure with a modified robustness optimization approach for enhancing the error compensation effectiveness and robustness of filters utilized in GNSS challenge conditions is proposed in this paper. The proposed method modifies the CKF scheme by incorporating nonlinear regression and numerous iteration processes for ameliorating error compensation. Subsequently, a loss function and penalty mechanism are implemented to enhance the filter's robustness to outlier measurements. Further, to fully absorb the valid information of the innovation and speed up the operation of the proposed method, the outlier measurement detection criteria is established to bypass the penalty mechanism against measurement weights in the absence of outliers in GNSS measurements. Field experiments demonstrate that the proposed method outperforms traditional methods in mitigating navigation errors when multipath errors and non-line-of-sight (NLOS) reception are increased.