bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengamanan Transkrip Mahasiswa Menggunakan Kriptografi Playfair Cipher
Authors: Faadhil Ali Muhammad , Mulyana Dadang Iskandar , Nawangsah Ghofurur , Saptan Lerry Salasi 
Published: May 2023

Jika kita mengkirim pesan ke orang lain, tentu pesan yang dimaksud penting dan kita berusaha untuk menjangkau orang yang tepat secepat mungkin. Pesan yang dikirim tentunya menjadi salah satu hal yang paling penting untuk disampaikan. Untuk memastikan bahwa pesan aman sampai orang yang tepat menerimanya, itu harus dirahasiakan dan tidak dicurigai oleh orang lain. Kombinasi penulisan cipher dengan cipher dapat lebih meningkatkan keamanan pesan, dan teknik cipher yang digunakan dalam penelitian ini adalah playfair cipher. Karena merupakan salah satu cipher sustitusi yaitu setiap huruf pada plainteks diganti dengan huruf dari keyoard. Jumlah karakter dalam kata sandi akan selalu genap. Kata sandi Playfair hanya dapat digunakan untuk enkripsi dan dekripsi data dalam teks alfaet karakter non-alfanumerik dapat dihindari dengan menuliskannya seagai teks alfaet. Enkripsi dan dekripsi data menggunakan kominasi dua huruf sehingga akan menyulitkan kriptanalis yang menggunakan analisis frekuensi untuk memecahkan sandi Playfair. Keyoard hanya digunakan sekali karena kemungkinan keyoard telah diool oleh pihak yang tidak erwenang.
KETERAMPILAN MENGAJAR GURU TERHADAP HASIL BELAJAR EKONOMI
Authors: Murniwati Halawa, Rijal, Cita Ayni Putri Silalahi  
Published: May 2023

Keterampilan dasar mengajar bagi guru diperlukan agar guru dapat melaksanakan perannya dalam pengelola proses pembelajaran, sehingga pembelajaran dapat berjalan secara efektif dan efesien. Berdasarkan hasil observasi awal yang saya lakukan di SMK Negeri 1 Lolotua, di peroleh data bahwa kemampuan guru berbeda-beda, hal ini ditunjukan dari perbedaannya masih ada guru yang kurang terampil dalam menyampaikan pembelajaran. Dan diproleh data dari seorang guru mata pelajaran ekonomi disekolah tersebut, bahwa ditinjau dari segi kemampuan bahwasannya kemampuan siswa berbeda-beda. Perbedaan itu mengakibatkan hasil belajar yang bervariasi. Hipotesis penelitian ini adalah:“ada pengaruh keterampilan mengajar guru terhadap prestasi Belajar ekonomi siswa kelas XI SMK Negeri 1 Lolotua TA. 2021/2022. Populasi dalam penelitian ini adalah siswa di Kelas XI SMK Negeri 1 Lolotua TA.2021/2022 berjumlah 355 siswa dengan jumlah sampel sebanyak 50 orang (random sampling). Dari hasil pembahasan dan analisa data yang di peroleh ternyata terdapat pengaruh yang positif antara keterampilan guru mengajar terhadap prestasi belajar ekonomi kelas XI SMK Negeri 1 Lolotua TA. 2021/ 2022. Dari perhitungan di bawah menunjukkan bahwa besarnya nilai (hitung) adalah 3,26 sedangkan besarnya nilai t (tabel) n = 50 dan α = 0,05 adalah 2,011 dengan demikian rumusan hipotesis yang telah ditetapkan dalam penelitian ini dapat di terima kebenarannya sebab t (hitung) > t (tabel), 3,26 > 2,011.
Klasifikasi Kematangan Buah Mangga Madani Berdasarkan Bentuk Dengan Jaringan Syaraf Tiruan Metode Perceptron
Authors: Hermanto Laia Finis , Rosnelly Rika , Buulolo Karuniaman , Lase Mega Christin , Naswar Alvinur 
Published: May 2023

Proses pendeteksian gambar secara otomatis merupakan bentuk dari kecerdasan buatan sehingga sistem dapat mengidentifikasi jenis gambar tertentu yang dikenal sebagai visi komputer. Mangga merupakan buah sesekali musiman yang memiliki banyak varietas namun beberapa jenis mangga memiliki bentuk yang hampir sama. Parameter pengenal yang diperoleh dari hasil ekstraksi ciri dapat dipadukan dengan teknik pengolahan citra digital sehingga terbentuk suatu sistem yang dapat mengklasifikasikan jenis mangga berdasarkan kematangan dari buah tersebut. Hal ini menyebabkan masyarakat keliru dalam memilih jenis kematangan buah mangga. Penentuan penamaman klasifikasi buah mangga madani dengan jaringan syaraf tiruan metode perceptron menggunakan software matlab. Pada penelitian ini data latih dan data uji yang digunakan masing-masing 40 citra buah mangga madani diantaranya 10 citra mentah, 10 citra cukup matang, 10 citra matang, dan 10 citra sangat matang. Pada proses data uji yang di hasilkan mendapatkan tingkat akurasi pengujian 50%.

Kata Kunci : Mangga, Jaringan Syaraf Tiruan, Matlab
Implementation of Enterprise Resource Planning (ERP) in Indonesia to Increase the Significant Impact of Management Control Systems
Authors: Rahardja Untung 
Published: May 2023

To improve the Management Control Systems, an accidental sampling (non-probability sampling) method is used to apply Enterprise Resource Planning (ERP). Export and import service companies in the Jakarta Capital City area became the population in this study, with the total sample used is 100 respondents. 3 (three) variables that are the primary key of this research are Management Control System (X1) is an independent variable, and ERP implementation (Y) is classified as a related variable. The results obtained after this study's test indicate that ERP implementation (Y) is significantly influenced by the Management Control System (X1). There are several compromises in implementing an ERP (Enterprise Resource Planning) system in Indonesia. These factors exist in both the manufacturing and service industries. These have been identified as staffing issues where users do not understand how to use the ERP system. This lack of understanding leads to the implementation of non-optimized ERP due to the lack of education and learning about system usage and operational know-how. ERP is an evolution of Enterprise Resource Planning II (MRP II), a further development of Material Requirements Planning (MRP). ERP includes a warehouse management package as a first step, which is the supply control used in manufacturing or servicing products. The second phase of material requirements planning is the ERP route. In addition, the third phase of MRPII was the development of closed-loop MRP. ERP will emerge as Phase 4, an extension of MRP II and business processes. Extended ERP is the fifth phase of ERP, was introduced in 2000 and is much more complex than previous ERP.
Canadian-Trinidadian Activism: Navigating Intersectional Identity in Queer Care
Authors: Chapman Julia 
Published: May 2023

For Trinidadian-Candian Queer activists, identity must be navigated through queer identity, ethnic community, and cultural background. This paper seeks to explore what Trinidadian Canadian QTBIPOC and allied activism and care can look like in Canada and how this activism is informed by this complex intersectional identity. This research was conducted under the supervision of Professor Tara Goldstein and postdoctoral fellow Jenny Salisbury as part of a Research Opportunity Program (ROP) towards a larger project focused on 60 Years of Queer, Trans, BIPOC (QTBIPOC) Activism and Care. This paper focuses on research into three activists via the ArQuives: Richard Fung, Anthony Mohammed, and Deb Singh. Richard Fung informs complex art-based activism through his complex identities as Trini, Chinese, Canadian, and a gay man. Fung presents an example of complex identity informing complex activism, for Fung, this is film-based art that spans and explores the many topics surrounding his identity. Anthony Mohammad and Deb Singh present similar experiences of complex identity as Trinidadians within a South Asian diaspora and identity within Queer communities. For Mohammad navigating his sexuality as a gay man through Caribbean and South Asian communities presents contradicting yet synchronous experiences of inclusion and exclusion. Mohammed exhibits complex activism through his work in varied queer groups intended for Caribbean and South Asians separately. Singh similarly identifies the acceptability of a particular identity; navigating fluid sexuality, binary gender, and monogamy presents a similar thread of contradicting inclusion and exclusion. Her activism presents through her work in bathhouses for women and nonbinary folx and her work in the Toronto Rape Crisis Centre and Ontario Coalition of Rape Crisis Centres. For Trinidadian-Candian Queer activists, their complex navigation of intersectional identities informs their community work and artistic expression as activists.
Втручання лікарських засобів у лабораторні тести
Authors: Бухтіарова Т. 
Published: May 2023

Втручання лікарських засобів у клінічні лабораторні тести (Drug Laboratory Tests Interference, DLTI) in vivo та/або in vitro є важливою, але не до кінця вивченою медичною проблемою.
Результатом таких втручань може стати запізнення встановлення та/або встановлення помилко- вого діагнозу, призначення непотрібних додаткових аналізів або терапії, додаткового моніторингу лікування, що завдає шкоди пацієнтам, підвищує фінансове навантаження на охорону здоров’я, фізичне навантаження на лікарів і спеціалістів з лабораторної діагностики.
Аналіз стану проблеми свідчить про те, що основним джерелом інформації щодо фізіологічних DLTI є інструкції для медичного застосування лікарських засобів, аналітичних – спонтанні повідомлення.
Наявна інформація не є вичерпною, стосується переважно однокомпонентних лікарських засо- бів, носить фрагментарний характер, недостатньо документована, відсутня уніфікована система збору й аналізу повідомлень про DLTI, не розроблені сучасні інструменти їхньої оцінки та алгоритми прийняття клінічних рішень.
Шляхи вирішення проблеми вбачаються в проведенні системних досліджень щодо втручань лікарських засобів у лабораторні тести (включно при застосуванні фіксованих комбінацій або одно- часному застосуванні декількох лікарських засобів), з’ясуванні механізмів виявлених інтерференцій, розробці підходів до отримання та верифікації інформації, створенні інформаційних експертних систем на підтримку клінічних рішень.
Актуальними також є питання перегляду навчальних програм у медичних закладах, зокрема щодо клінічних лабораторних досліджень, їхнього відбору й інтерпретації результатів, а також підготовки експертів-консультантів з лабораторної діагностики.
Визначення вмісту важких металів (As, Cd, Hg, Pb) у дієтичних добавках, фармацевтичній і лікарській рослинній сировині методом атомно-емісійної спектрометрії з індуктивно зв’язаною плазмою
Authors: Брицун В. М. , Кузнецова О. М. , Очеретяна Н. М. , Лєвін М. Г. , Останіна Н. В. 
Published: May 2023

Мета дослідження – визначення вмісту важких металів (As, Cd, Hg, Pb) методом атомно-емісійної спектрометрії з індуктивно зв’язаною плазмою в дієтичних добавках, фармацевтичній і лікарській рослинній сировині, що передані для випробовувань на їхню відповідність вимогам нормативної документації; порівняльний аналіз отриманих результатів.
Дослідження здійснювали на оптико-емісійному спектрометрі з індуктивно зв’язаною плазмою Agilent 5800 ICP-OES. Вимірювання вмісту металів проводили шляхом порівняння емісії досліджуваних розчинів з емісією стандартних розчинів за довжин хвиль: As 188,980 нм, Cd 226,502 нм, Hg 184,887 нм, Pb 220,353 нм.
Виміряно вміст важких металів (As, Cd, Hg, Pb) у 41 зразку (дієтичних добавках, вітамінно-міне- ральному комплексі, фармацевтичній і лікарській рослинній сировині). Випробувались 18 зразків на вміст As, 26 зразків – Cd, 23 зразка – Hg, 37 зразків – Pb. Концентрації більші ніж межа виявлення приладу зафіксовані щодо Pb у 86,5 % зразків, Cd – 76,9 %, As – 72,2 %, Hg – 13,1 %.
Помітне забруднення випробовуваних зразків важкими металами спостерігалось: для Pb – 12 зразків (32,4 % випробуваних, з них для лікарської рослинної сировини та дієтичних добавок – 9,0–44,8 % нормування, для фармацевтичної сировини – 6,8–37,9 % нормування); для As – 5 зразків (27,8 % випробуваних, 9,1–47,8 % нормування); для Cd – 5 зразків (19,2 % випробуваних, 9,2–14,6 % нормування); для Hg – 3 зразки (13 % випробуваних, 42,5–62 % нормування). Значний вміст важких металів (Cd 84–145,5 мкг/кг, Pb 884–1343 мкг/кг, Hg 33,8 мкг/кг) спостерігається в таких органах рослин, як коріння.
Не зафіксовано жодного перевищення дозволених концентрацій важких металів у випробуваних зразках, що свідчить про належну якість продукції.
Comparative Analysis of Quality of Essential Oil of Wormwood Herb Synanthropic Flora of Voronezh Region
Authors: Dyakova N. A. , Korenskaya I. M. , Slivkin A. I. 
Published: May 2023

Introduction. The formation and accumulation of biologically active substances in plants is a complex process associated with a number of environmental factors, including anthropogenic ones. The study of the characteristics of the qualitative composition of essential oil of wormwood grass of bitter different from the ecological point of view of the places of harvesting is relevant.Aim. The aim of this study study of the qualitative composition of essential oil of bitter wormwood grass, harvested in areas of the Voronezh region that are different from an ecological point of view.Materials and methods. In the Voronezh region, 4 points of raw materials procurement were selected, diverse in terms of anthropogenic impact. Isolation of essential oil from the raw materials was carried out according to the method of PS "Wormwood of bitter grass". Component composition of the obtained essential oils was determined using Agilent 7890B GC System (Agilent Technologies, USA) with Agilent 5977A MSD mass selective detector (Agilent Technologies, USA). Data analysis and processing was carried out on the basis of NIST11 databases (from 19.05.2011), MassHunter ver. B.06.00 and NIST MS Search ver. 2.0 software were used.Results and discussion. In a sample of essential oil obtained from reserved raw materials, monoterpene compounds account for more than 82 %, and sesquiterpene compounds – 16.6 %, about 2 % are organic impurities. Intensive biosynthesis of monoterpenes was noted in a sample collected in the area of agricultural fields of the Verkhnekhavsky district, its mass fraction is more than 73 %. In samples of raw materials with anthropogenic load (OJSC "Minudobreniya" and Highway M4), the share of monoterpene compounds is significantly lower (63.7 and 49 %, respectively). The increase in the proportion of sesquiterpene compounds in the last samples of wormwood essential oil may be due to the excessive acidity of the urbanized places of the workpiece. The sesquiterpene compound hamazulene, which stains essential oil blue, is identified in only two samples of gorse grass wormwood harvested along agricultural fields and in M4 tracks, which explains the presence of a blue hue in these oils.Conclusion. The chromato-mass spectrometric analysis of the essential oil of the studied samples of bitter wormwood grass made it possible to identify more than 70 different components in them, while the qualitative composition of the essential oil of the raw materials of different places of the workpiece was significantly different, which may indicate a significant influence of the place of growth of the species and anthropogenic factors on the features of the secondary metabolism of terpene compounds in the plant organism.
Physicochemical and Functional Characterization of Medicinal Product Rinsulin® R
Authors: Babina A. V. , Drai R. V. , Saparova V. B. , Afanasyeva A. N. , Zaikin P. G. , Shmurak V. I. , Eltysheva T. E. , Makarenko I. E. 
Published: May 2023

Introduction. Currently, biosimilars have found quite widespread use in the treatment of a number of chronic and life-threatening diseases. Thanks to them, there is a significant decrease of the economic pressure of biological drugs on the health care system and wide access of patients to effective and safe medicines is ensured. One of the most important stages of proving biosimilarity is the physicochemical and functional characterization of proteins. This set of studies is generally accepted, as sensitive as possible and allows us to give a conclusion about the compliance of the biosimilar with the original drug.Aim. Conducting physicochemical and functional characterization of medicinal product Rinsulin® R (GP40051) in comparison with the original drug Humulin® Regular.Materials and methods. Primary structure was analyzed by high-performance liquid chromatography with mass spectrometry detection and matrix assisted laser desorption/ionization. The identity of the higher protein structures was proved by the methods of circular dichroism, capillary isoelectric focusing, spectrometry and dynamic light scattering. The comparability of the impurity profiles of the preparations was evaluated using the methods of exclusive chromatography and reverse-phase high-performance liquid chromatography. Functional characterization included a metabolic cell test "glucose uptake" and insulin receptor–binding assay (kinetics of binding to type A and B receptors, phosphorylation of insulin receptor).Results and discussion. In the course of this research, the identity of the physicochemical and functional characteristics of GP40051 was shown. A complete overlap of primary sequence, high-order structures and impurity profiles was demonstrated between the comparison drug GP40051 and the reference drug Humulin® Regular. Functional studies have shown that GP40051 and Humulin® Regulars have the same activity.Conclusion. The results of the quality comparability study demonstrated similarity of Rinsulin® R to the reference medicinal product Humulin® Regular, providing the scientific basis for conducting a specifically designed clinical programme, and supported registration in Russian Federation.
Overview of Piperidine and Morpholine Derivatives as Promising Sources of Biologically Active Compounds (Review)
Authors: Khamitova A. E. , Berillo D. A. 
Published: May 2023

Introduction. The search for new, effective and safe pharmacologically active substances remains an urgent task in the field of pharmacy. Many compounds of the piperidine and morpholine series are widely used in medical practice and belong to an important group of biologically active compounds. An informational, literature search on the synthesis of new derivatives of piperidine and morpholine was carried out. The article summarizes the results of studies of new derivatives of piperidine and morpholine as potential sources of biologically active substances.Text. The review is devoted to the relationship between the pharmacological activity of the N-derivatives of piperidine and morpholine in relation to various biological targets and the structure of the substance, the importance of the piperidine and morpholine rings in the design and development of drugs is highlighted. Piperidine and morpholine are considered as prerogative structures not only for increasing activity, but also for obtaining biological substances with desired therapeutic properties and improved pharmacokinetics.Conclusion. The literature review shows the current trend towards the study of morpholine and piperidine derivatives, reveals their high pharmacophore activity. The review will provide researchers with the necessary knowledge base to make chemical structural changes to the structures of drug leaders to enhance pharmacological activities.
Phytochemical Analysis of the Aerial Part of Golden Dock (<i>Rumex Maritimus</i> L.)
Authors: Podgurskaya V. V. , Luksha E. A. , Savchenko I. A. , Korneeva I. N. , Ivanova E. V. 
Published: May 2023

Introduction. Golden dock (Rumex maritimus L., Polygonaceae) is used as a medicinal and food plant in Asian countries. The plant contains phytochemicals of various classes: flavonoids, tannins, anthraquinones etc. Plant extracts exhibit antibacterial, antioxidant, anti-inflammatory, astringent activity, and have antidiabetic potential. The plant is annual, and most of the biologically active substances accumulate in its aboveground organs. An important problem is the standardization of Rumex maritimus and the development of regulatory documentation for its the introduction to medical practice.Aim. To conduct phytochemical analysis of the aerial part of golden dock.Materials and methods. Air-dried aerial part of Rumex maritimus collected at flowering and beginning of fruiting stage, as well as individual above-ground organs (leaves, flowers, fruits, stems), were used for obtaining the extracts. Qualitative analysis of the extracts was carried out using reverse phase HPLC. The relative content of the components in the mixture was calculated by the method of simple normalization. Total content of free anthraquinones and anthraglycosides in terms of chrysophanic acid was determined using spectrophotometric method after acid hydrolysis. Total tannin content was calculated by titrimetric method.Results and discussion. Flavonoids isoquercetin and avicularin were first discovered in the aerial part of Rumex maritimus. The dominant component of the plant is rutin. Chrysophanol predominates among anthraquinones. The highest concentration of anthraquinones (2.80 ± 0.04 %) was found in flowers. Tannins accumulate mainly in leaves (9.97 ± 0.02 %). A significant amount of tannins (6.60 ± 0.03 %) and anthracene derivatives (1.96 ± 0.03 %) is contained in the whole aerial part.Conclusion. Phytochemical analysis of the aerial part of Rumex maritimus showed the presence of a significant amount of anthraquinones. As a plant raw material it is proposed to use the herb of Rumex maritimus. Standardization is recommended for anthraquinones in terms of chrysophanic acid (at least 1.5 %).
Properties of Mucoid Serotype 3 Streptococcus pneumoniae From Children in China
Authors: Yang Ying , Hua Chun-Zhen , Fang Chao , Xie Yong-Ping , Li Wei , Fu Yong , Gao Feng , Yao Kai-Hu 
Published: May 2023

ObjectiveTo investigate the characteristics of hosts, antimicrobial susceptibility, and molecular epidemiology of mucoid serotype 3 Streptococcus pneumoniae (S. pneumoniae) isolated from children in China.MethodS. pneumoniae isolates collected between January 2016 and December 2019 were analyzed. S. pneumoniae isolates with mucoid phenotype were selected visually, and serotype 3 isolates were confirmed by Quellung reaction. The antimicrobial susceptibility was measured by E-test. Multilocus sequence typing was used for clonal analysis.ResultsTwenty (3.04%) isolates of mucoid serotype 3 S. pneumoniae were identified from 657 clinical isolates, and all of them were noninvasive strains. The mean age of the hosts was 5.69 ± 3.28 years. The isolates included: 50.0% from the dissected tonsil or adenoid tissue in children with obstructive sleep apnea-hypopnea syndrome, 45.0% from sputum or bronchial lavages in children with pneumonia, and 5.0% from vaginal secretions of one patient with vulvovaginitis. All isolates were susceptible to penicillin, cefuroxime, ceftriaxone, meropenem, vancomycin, levofloxacin, trimethoprim/sulfamethoxazole, and rifampin but resistant to erythromycin. Sequence type (ST)505 and its clonal complex (CC) were the main genotypes (95%). Antimicrobial susceptibility of ST180 and ST505 were compared, and the minimum inhibitory concentration (MIC) of ST505 isolates was significantly higher than that of ST180 for tetracycline, trimethoprim/sulfamethoxazole, and meropenem.ConclusionsMucoid serotype 3 Streptococcus pneumoniae can be isolated from various body parts, among which the respiratory system is the most common. It can cause noninvasive infection in children, and it has high susceptibility to a variety of antibiotics, especially β-lactams, but is resistant to macrolides. CC505 is the novel clonal complex found in China, which may be related to the worldwide mainstream clonal complex (CC180) but has its own biological characteristics.