bluuebunny/crossref_metadata_2025_split huggingface dataset:
SERRA DA MIABA, POVOADO CURITUBA E VALE DOS MESTRES (SE), COMO EVIDÊNCIAS GEOLÓGICAS DE PERÍODOS GLACIAIS E INTERGLACIAIS DO PASSADO SERGIPANO
Authors: Figueiredo Felipe Torres , Da Silva Elias José , Lenz Cristine , Santana Mateus do Nascimento , Santos Andriel Lima , Gomes Pedro Victor de Oliveira 
Published: June 2023

A Serra da Miaba, localizada na região centro-oeste do estado de Sergipe e o Vale dos Mestres, no extremo noroeste, compõem importantes pontos turísticos de Sergipe. Cada qual pode ser interpretado como a memória do ambiente de formação de rochas, de onde é possível extrair informações sobre climas glaciais e interglaciais na história geológica não só do Estado, mas de escala global. Contudo, apesar do tema ser muito debatido na literatura científica e de grande relevância para as discussões sobre aquecimento global, é pouco conhecido pelo grande público e por turistas. No sentido de suprir esta deficiência de informações e melhorar o conhecimento de guias e condutores de trilhas, principais agentes de comunicação com o grande público, a presente contribuição objetivou ilustrar dois exemplos de rochas que comprovam a existência de variações climáticas acompanhadas de mudanças na paisagem do passado sergipano. O primeiro exemplo está preservado na Formação Tacaratu, unidade de rochas aflorantes no Vale dos Mestres, interpretada como produto de rios ancestrais ao Rio São Francisco, capazes de transportar sedimentos por uma extensa rede de drenagens desde Sergipe até o Ceará, entre os períodos Siluriano e Devoniano, há 440-360 milhões de anos (Ma), quando a vegetação ainda era escassa sobre os continentes. No entorno do vale, próximo ao povoado Curituba, porém de idade mais jovem (Permo-carbonífera 360 – 250 Ma), estão preservadas as melhores evidências de abrasão e deformação por geleiras do Estado, em um período que a América do Sul e África estavam unidas e faziam parte de um supercontinente chamado Gondwana. Já as evidências da transição entre eventos glaciais e interglaciais de maior profundidade do tempo geológico em Sergipe, foram deixadas ao longo do Neoproterozoico (cerca de 800 Ma atrás), respectivamente, nas rochas das formações Ribeirópolis e Jacoca, localizadas na Serra da Miaba. Este registro estratigráfico, ou seja, do empilhamento das rochas, inclui Sergipe, assim como Bahia, Minas Gerais e o Mato Grosso, como uma das áreas influenciadas por processos glaciais de maiores proporções que se tem conhecimento na história do planeta.
MEDIATING ROLE OF DEPRESSION AND ANXIETY ON SOMATIC COMPLAINTS IN GEORGIAN SERVANTS WITH POST TRAUMATIC STRESS DISORDER
Authors: Sikharulidze Giorgi , Sordia Mariam , Vermetten Eric 
Published: June 2023

Background and Objectives: The relationship between Post Traumatic Stress Disorder (PTSD) and somatic symptoms and the role of comorbid depression and anxiety has been demonstrated in many studies. The following research explores to what extent depression and anxiety influence the relationship between PTSD and somatic complaints in Georgian peacekeepers.
Design and Methods: PTSD Checklist (PCL-5) for The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and Patient Health Questionnaire (PHQ) was used to collect data in the sample of 75 veterans examined after a 6-month deployment. Two types of parallel mediation model 4 of the SPSS PROCESS macro were used to check different and also joint influences of depression and anxiety on the indirect effect of PTSD on somatic complaints.
Results: When probable mediators were analyzed separately, there was a significant indirect effect of PTSD on somatic complaints: through depression 0.21, 95% CI [0.13, 0.28], and through anxiety 0.13, 95% CI [0.06, 0.21]. After placing both mediators in a parallel model, only depression maintained statistical significance: 0.18, 95% CI [0.09, 0.28]. The ratio of indirect to total effect was 0.66, 95% CI [0.59, 0.75].
Conclusions: The primary finding is that the relationship between PTSD and somatic complaints may be mainly accounted for underlying symptoms of depression rather than anxiety, highlighting the importance of targeting depression symptoms when diagnosing and treating comorbid PTSD and somatic complaints. These new results may affect both the management and treatment of PTSD as they acknowledge the importance of anxiety and depression symptoms in somatic complaints.
Límites a la competencia de la Dirección Jurídica y la Subdirección de Nor¬mativa y Doctrina de la DIAN como autoridad doctrinal
Authors: Díaz Acuña Andrea 
Published: June 2023

La doctrina oficial ha cobrado gran relevancia en el sistema de fuentes para el derecho tributario, debido a su obligatoriedad para los funcionarios de la Administración de im­puestos nacionales en el desarrollo de sus funciones, de la misma forma, en búsqueda de la seguridad jurídica de los actores debida a la constante evolución y carácter técnico del derecho tributario.
Por lo anterior, se analizarán algunos pronunciamientos doctrinales expedidos por la Administración de Impuestos con el propósito de analizar si la competencia se ha desa­rrollado de acuerdo con el marco legal atribuido para el desarrollo de su actividad como autoridad doctrinal.
ГУМАНІСТИЧНА ПАРАДИГМА В МЕНЕДЖМЕНТІ: ВІД КУЛЬТУРИ ГІДНОСТІ ДО КУЛЬТУРИ МЕНЕДЖМЕНТУ
Authors: Гусаченко В. В. , Горячковська Г. М. , Дашенкова Н. М. , Коробкіна Т. В. 
Published: June 2023

Робота присвячена обґрунтуванню нагальної потреби переходу від економічної та організаційної парадигми менеджменту до подальшого, більш системного і цілісного, розвитку гуманістичної парадигми менеджменту. Спроба вирішення кризи, що виникла, вбачається нами в переході на екзистенціальний рівень осмислення проблеми. В статті проаналізований зв’язок сучасного стану гуманістичного менеджменту з культурою гідності та невичерпними можливостями людської природи.
Panoramas de producción y redes de colaboración científica. Indicadores y comparativos. Suramérica y otros países
Authors: Gómez Velasco Nubia Yaneth , Ayala Montoya Luisa Fernanda , Gómez Velasco Nancy Sofia 
Published: June 2023

Objetivo: Realizar un análisis comparativo de la producción científica entre América del Sur y otras latitudes. Se aporta el estudio y análisis de variables en torno a la producción a partir de cartogramas, número de investigadores por millón de habitantes, recursos de inversión en CTeI y redes de colaboración, entre otros.

Originalidad/aporte: La producción de conocimiento científico se ha ido constituyendo en un factor importante en los países y en las instituciones de educación superior, al ser asociado como un indicador de desarrollo, con principios exigidos por agencias acreditadoras de calidad.

Método: Se enfoca bajo una estructura cuantitativa descriptiva, con ayuda de indicadores relacionales.

Estrategias/recolección de información: Recolección de información a través de los cartogramas con el fin de determinar la tendencia de brechas a partir de densidades de mapeo, mostrando un crecimiento notable en países de Asia. Colombia, al ser comparado con países de Sur y Centro América, muestra indicadores de producción por debajo de Brasil, Argentina y México, con menor recurso humano e inversión; sin embargo, al calcular valores relativos a su contexto, el panorama cambia sustancialmente.

Conclusiones: En relación con las redes de colaboración, motivadas por la crisis de pandemia, se concluye un incremento de participación internacional a través de las coautorías de los artículos científicos en el sector salud, con un promedio aproximado del 50 %. Se destaca que la mayor parte de estas investigaciones fueron realizadas en instituciones de educación superior.
The Influence of Price and Promotion on Consumer Purchase Decisions at Sumber Makmur Kopi Jember
Authors: Susana Fera Angelia , Julianto Didik Eko , Suhartono Suhartono 
Published: June 2023

Penelitian ini bertujuan untuk menganalisis pengaruh harga dan promosi terhadap keputusan pembelian konsumen di Sumber Makmur Kopi Jember. Jenis penelitian ini adalah penelitian kuantitatif. Populasi pada penelitian ini merupakan konsumen yang melakukan pembelian di Sumber Makmur Kopi secara langsung. Jumlah sampel pada penelitian ini berjumlah 65 responden. Teknik sampel pada penelitian menggunakan tipe nonprobability sampling menggunakan metode accidental sampling. Teknik pengumpulan data yang digunakan yaitu dengan kuesioner. Uji instrumen yang digunakan yaitu uji validitas dan uji reliabilitas. Penelitian ini menggunakan analisis regresi linear berganda dengan menggunakan uji T dan uji F. Hasil uji T menunjukkan bahwa harga dan promosi secara parsial berpengaruh signifikan terhadap keputusan pembelian konsumen. hasil uji F menunjukkan bahwa harga dan promosi secara simultan berpengaruh signifikan terhadap keputusan pembelian.
Kata Kunci: Harga, Promosi, dan Keputusan Pembelian
Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus?
Authors: Taslamacioglu Duman Tuba , Balci Buse , Ozkul Feyza Nihal 
Published: June 2023

Background: The systemic inflammatory index (SII) is a new inflammatory marker that has been the subject of various studies in diseases with chronic inflammation. Diabetic nephropathy is also a disease that goes with chronic inflammation. We aimed to evaluate the relationship be-tween SII and diabetic nephropathy.
Methods: Patients with diabetes who applied to our outpatient clinic are included in the study. Diabetic patients are divided into two groups: those with diabetic nephropathy and those with-out. In addition, healthy individuals who applied to our clinic for general check-ups during these dates are included as control group. The SII values and other characteristics of the three study groups are compared.
Results: The median SII value for those with DKI was 584 (178-4819); for those without DKI, it was 282 (64-618); and for the control group, it was 236 (77.5-617) (p&lt;0.001). SII was significantly and positively correlated with BMI, weight, blood glucose, HbA1c, CRP and creatinine, and neg-atively correlated with glomerular filtration rate (GFR) value. The SII value higher than 336 has 75% sensitivity and 70% specificity in detecting DKI.
Conclusion: The SII value could predict diabetic kidney injury in diabetics and it could be used as an adjunctive diagnostic tool.
CALCULATION OF GAS-DYNAMICS PARAMETERS AND STRESS-STRAIN STATE OF CELSIAN CERAMICS PRODUCTS
Authors: Lisachuk Georgiy , Tkachuk Mykola А. , Vasyliev Anton , Breslavsky Dmytro , Kryvobok Ruslan , Voloshchuk Valentyna 
Published: June 2023

In the work using the finite element method, an analysis of the behavior of nose fairings made of radio-transparent ceramic materials of celsian composition was carried out. Determination of parameters of gas dynamics and stress-strain state was carried out using licensed ANSYS software. SSG Reynold Stress turbulence model was chosen for accurate air flow simulation. Geometric and finite element models were used to calculate strength and temperature fields. The analysis of the results of gas-dynamic calculations shows that at the point of transition of the conical part of the rocket into the cylindrical part, there is a sharp change in the flow conditions and a disruption of the flow in the range of speeds of 100-1100 m/s. As a result of modeling the distribution of temperature fields with the stated task, it was established that the temperature on the inner surface of the fairing differs from the temperature on the outer surface by no more than ±1 °C on average, and the maximum surface heating temperature does not exceed 550 °C. According to the results of calculations of the stress-strain state under temperature regimes that simulate the conditions of their operation, it was concluded that under the considered conditions the equivalent (≤ 69.3 MPa) and main (≤ 40 MPa) stresses occurring in the nose fairing are not exceed the bending strength limit for celsian ceramics (290 MPa). It can be observed that the maximum temperature difference in thickness corresponds to the part of the fairing with the minimum radius. Movements on the surface of the fairing do not exceed 0.25 mm, which is acceptable according to the specified parameters. The parametric model provides advantages in justifying rational technical solutions. Ultimately, the nose fairing, made of celsian ceramics, will maintain its integrity in real operating conditions.
Keywords: radiotransparent celsian ceramics; nose fairing; finite element method; gas dynamics; thermophysical calculations; strength; stress-strain state
Penerapan Prinsip Ekowisata dalam Penyelenggaraan Pariwisata Alam di Taman Wisata Alam (TWA) Kawah Ijen
Authors: Fitriawati Fitriawati , Suroso Djoko Santoso Abi 
Published: June 2023

Taman Wisata Alam (TWA) Kawah Ijen merupakan salah satu destinasi wisata unggulan nasional. Sebagai kawasan konservasi, prinsip ekowisata harus dipenuhi untuk dapat mengakomodasi peruntukan pariwisata dan fungsi konservasinya. Hal ini untuk meminimalkan potensi dampak negatif dari semakin meningkatnya pengunjung TWA Kawah Ijen. Tulisan ini memaparkan kajian penerapan prinsip ekowisata di TWA Kawah Ijen dengan metode kualitatif. Hasil penelitian menunjukkan bahwa praktik ekowisata di TWA Kawah Ijen belum memenuhi prinsip ekowisata secara menyeluruh. Pelaksanaan ekowisata di kawasan tersebut cenderung memenuhi prinsip kedua, yaitu peningkatan sosial ekonomi masyarakat lokal melalui pelibatan masyarakat, sedangkan prinsip konservasi dan prinsip edukasi masih belum terlaksana dengan baik.

Kata Kunci: ekowisata, konservasi, pariwisata berkelanjutan, taman wisata alam
SurvInt: A simple tool to obtain precise parametric survival extrapolations
Authors: Gallacher Daniel 
Published: June 2023

Abstract
Background
Economic evaluation of emerging health technologies is mandated by agencies such as the National Institute for Health and Care Excellence (NICE) to ensure their cost is proportional to their benefit. To avoid bias, NICE stipulate that the benefit of a treatment is assessed across the lifetime of the patient population, which can be many decades. Unfortunately, follow-up from a clinical trial will not usually cover the required period and the observed follow-up will require extrapolation. For survival data this is often done by selecting a preferred model from a set of candidate parametric models. This approach is limited in that the choice of model is restricted to those originally fitted. What if none of the models are consistent with clinical prediction or external data?
Method/Results
This paper introduces SurvInt (formerly SurvExtrap), a tool that estimates the parameters of common parametric survival models which interpolate key survival time co-ordinates specified by the user, which could come from external trials, real world data or expert clinical opinion. This is achieved by solving simultaneous equations based on the survival functions of the parametric models. The application of SurvInt is shown through two examples where traditional parametric modelling did not produce models that were consistent with external data or clinical opinion. Additional features include model averaging, background mortality, piecewise modelling and probabilistic sensitivity analysis.
Conclusions
SurvInt allows precise parametric survival models to be estimated and carried forward into economic models. It provides access to extrapolations that are consistent with multiple data sources such as observed data and clinical predictions, opening the door to precise exploration of regions of uncertainty/disagreement. SurvInt could avoid the need for post-hoc adjustments for complications such as treatment switching, which are often applied to obtain a plausible survival model. Phase III clinical trials are not designed with extrapolation in mind, and so it is sensible to consider alternative approaches to predict future survival that incorporate external information.
Expert Consensus on the Management of Advanced Clear-cell Renal Cell Carcinoma: Indian Perspective (Pearl-india)
Authors: Sahoo Tarini Parad , Desai Chirag , Aggarwal Shyam , Rauthan Amit , Dabhar Boman , Biswas Ghanashyam , Batra Sandeep , Saha Rajat , Phillips Arun , Agarwal Vijay , Dattatreya Palanki Satya , Mohapatra P N , Deshmukh Chetan , Bhagat Sagar , Patil Saiprasad , Barkate Hanmant 
Published: June 2023

Abstract

In advanced Renal Cell Carcinoma (aRCC), systemic therapy is the mainstay of treatment, with no or little role for surgery in these patients. Tyrosine kinase inhibitors (TKIs) and immune-oncological (IOs) therapies, either alone or in combination, are recommended in these patients depending on patient and tumour factors. The sequencing of therapies is critical in RCC because the choice of subsequent line therapy is heavily dependent on the response and duration of the previous treatment. There are additional barriers to RCC treatment in India. Immunotherapy is the cornerstone of treatment in ccRCC, but it is prohibitively expensive and not always reimbursed, effectively putting it out of reach for the vast majority of eligible patients in India. Furthermore, in advanced RCC (particularly the clear cell variety), Indian oncologists consider the disease burden of the patients, which is particularly dependent on the quantum of the disease load, clinical symptoms, and performance status of the patient, before deciding on treatment. There are no India-specific guidelines for clear cell RCC (ccRCC) treatment or the positioning and sequencing of molecules in the management of advanced ccRCC that take these country-specific issues into account. The current consensus article provides expert recommendations and treatment algorithms based on existing clinical evidence, which will be useful to specialists managing advanced ccRCC.
An improved self-organizing mapping neural network and its application in fault diagnosis of CNC machine tool servo drive system
Authors: Cheng Qiang , Cao Yong , Zhang Tao , Sun Liansheng , Xu Lei , Liu Zhifeng 
Published: June 2023

Abstract
The computer numerically controlled (CNC) system is the main functional component of the CNC machine tool control system, whose essential part is the servo-drive system. The failure cause of the servo-drive system can be challenging to diagnose due to the complex working environment. Therefore, effectively detecting servo-drive system faults ensures the regular operation of CNC machine tools. In this paper, an improved self-organizing mapped neural network method is proposed and applied to fault diagnosis of the servo-drive system. The MDC technology can identify hidden fault features in data and diagnose fault types based on various data collected by the MDC system and working parameter range indicators. The method's core is the self-organizing mapped neural network that employs the competitive learning mechanism of unsupervised learning to perform cluster analysis on data with different characteristics, find the winning neurons, and diagnose the fault data. In addition, feature standardization and principal component analysis are introduced to preprocess the input data set, which can balance the influence of different feature scales, enhance the fault data features, and reduce data dimension. The rationality of this technique in practical application is validated via a series of fault data sets tests. Lastly, the advantages of the proposed technique are verified by comparison with other standard methods.
Activation of LIMK/Cofilin signaling pathway via extracellular matrix-integrin interaction is critical for generation of mature and vascularized cardiac organoids
Authors: Noh Ji-Min , Choi Seung-Cheol , Song Myeong-Hwa , Kim Kyung Seob , Jun Seongmin , Park Jae Hyoung , Kim Ju Hyeon , Kim Kyoungmi , Ko Tae Hee , Choi Jong-Il , Gim Jeong-An , Kim Jong-Hoon , Jang Yongjun , Park Yongdoo , Na Ji Eun , Rhyu Im Joo , Lim Do-Sun 
Published: June 2023

Abstract
The generation of mature and vascularized human pluripotent stem cell-derived cardiac organoids (hPSC-COs) is necessary to ensure the validity of drug screening and disease modeling. This study investigates the effects of cellular aggregate (CA) stemness and self-organization on the generation of mature and vascularized hPSC-COs and elucidates the mechanisms underlying CO maturation and vascularization. H-COs were generated from early CAs with high stemness, and L-COs were generated from late CAs with low stemness under a self-organized microenvironment by Wnt signaling induction. The study finds that H-COs exhibit ventricular, structural, metabolic, and functional maturation of cardiomyocytes and vessel networks consisting of endothelial cells, smooth muscle cells, pericytes, and basement membranes compared to L-COs. Transcriptional profiling shows the upregulation of genes associated with cardiac maturation and vessel formation in H-COs compared with those in L-COs. Activation of ROCK-LIMK-pCofilin via ECM–integrin interaction leads to cardiomyocyte maturation and vessel formation in H-COs through experiments with LIMK inhibitors. Furthermore, the LIMK/Cofilin signaling pathway induces TGFβ/NODAL and PDGF pathway activation for the maturation and vascularization of H-COs. The study demonstrates for the first time that LIMK/Cofilin axis activation plays an important role in the generation of mature and vascularized COs.
Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis
Authors: Feng Jing , Chen Yexin , Liu Yan , Lin Lin , Lin Xiujuan , Gong Wenxiu , Xia Rongmu , He Jianquan , Sheng Jianwen , Cai Huimei , Xiao Chuanxing 
Published: June 2023

Abstract
Purpose
To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted.
Methods
To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (RR) and 95% confidence interval (CI) to combine our findings.
Results
A total of 13 RCTs on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [RR = 1.73; 95% CI = (1.41, 2.12); P < 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [RR = 1.74; 95% CI = (1.24, 2.44); P = 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [RR = 1.00; 95% CI = (0.86, 1.15); P = 0.96].
Conclusions
FMT is an effective treatment for UC with good clinical remission rates and endoscopic remission rates. However, safety remains a concern during treatment and measures must be taken to enhance both safety and success rates.