bluuebunny/crossref_metadata_2025_split huggingface dataset:
A research on data integration and application technology of urban comprehensive pipe gallery based on three‐dimensional geographic information system platform
Authors: Huang Yufang , Peng Hongtao , Fang Xiaoxiao , Xing Tingyan 
Published: April 2023

AbstractThree‐dimensional Geographic Information System (3D GIS) technology is often used in geology, mining, hydrology and other fields. It is also used in intelligent management of urban comprehensive pipe gallery projects, because the real environment with the sky, ground, and underground can be intuitively simulated in the virtual reality environment by 3D GIS platform. Through the research on data integration and application technology of urban comprehensive pipe gallery, the 3D model of comprehensive pipe gallery project data can be created based on Building Information Modelling and GIS technologies, and a comprehensive underground pipelines network management information system has been developed to realise the integration of various data, including 3D data of comprehensive pipe gallery model and underground pipe network model, 2D or 3D GIS data of the ground and underground etc. On this basis, the functions of intelligent planning and approval management, the safety analysis and disaster prevention planning and decision‐making of urban comprehensive pipe gallery projects can be further realised. The research results have been applied to the planning and construction process management of the comprehensive pipe gallery project in the sub‐centre of Beijing.
Hub genes and pathways in gastric cancer: A comparison between studies that used normal tissues adjacent to the tumour and studies that used healthy tissues as calibrator
Authors: Sadegh Khadijeh , Ahmadi Amirhossein 
Published: April 2023

AbstractSeveral bioinformatics studies have been performed on high‐throughput expression data to determine the cellular pathways and hub genes affected by Gastric cancer (GC). However, these studies differ in using a healthy tissue or normal tissue adjacent to the tumour (NAT) as calibrator tissues. This study was designed to find how using healthy or NAT tissues as calibrator tissues could affect pathway enrichment data and hub genes in GC. Two gene expression datasets with NAT tissues (GSE79973 and GSE118916) and one dataset with healthy tissues (GSE54129) were downloaded and processed by the limma package to screen the differentially expressed genes (DEGs). Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) enrichment analysis were performed by the Enrichr online tool. Protein‐protein interaction network construction, module analysis, and hub genes selection were performed by Cytoscape software, Molecular Complex Detection plugin, and cytoHubba plugin, respectively. The gene expression profiling interactive analysis web server was used to analyse RNA sequencing expression data from The Cancer Genome Atlas Program. The Kaplan—Meier plotter was used to perform survival analysis. Our results showed that some KEGG and GO pathways were shared between studies with NAT and the study with healthy tissues. However, some terms, especially inflammation‐related terms, were missed when NAT tissues were used as calibrator tissues. Also, only FN1 and COL1A1 are common hub genes between DEGs of the studies with NAT and healthy tissues. Since hub genes are usually extracted and suggested as candidate targets for GC diagnosis, prognosis, or treatment, selecting healthy or NAT tissues may affect the hub genes selection.
An extreme-ultraviolet wave associated with the possible expansion of sheared arcades
Authors: Liu Yihan , Zheng Ruisheng , Zhang Liang , Wei Hengyuan , Zhong Ze , Yang Shuhong , Chen Yao 
Published: April 2023

Context. Solar extreme-ultraviolet (EUV) waves are propagating disturbances in the corona, and they are usually accompanied with various solar eruptions, from large-scale coronal mass ejections to small-scale coronal jets.
Aims. Generally, it is believed that EUV waves are driven by the rapid expansion of coronal loops overlying the erupting cores. In this paper, we present an exception of an EUV wave that was not triggered by the expansion of coronal loops overlying the erupting core.
Methods. Combining the multiwavelength observations from multiple instruments, we studied the event in detail.
Results. The eruption was restricted in the active region (AR) and disturbed the nearby sheared arcades (SAs) connecting the source AR to a remote AR. Interestingly, following the disturbance, an EUV wave formed close to the SAs, but far away from the eruption source.
Conclusions. All the results show that the EUV wave had a closer temporal and spatial relationship with the disappearing part of SAs than the confined eruption. Hence, we suggest that the EUV wave was likely triggered by the expansion of some strands of SAs, rather than the expansion of erupting loops. It can be a possible complement for the driving mechanisms of EUV waves.
Europium enrichment and hierarchical formation of the Galactic halo
Authors: Cavallo L. , Cescutti G. , Matteucci F. 
Published: April 2023

Context.The origin of the large star-to-star variation of the [Eu/Fe] ratios observed in the extremely metal-poor (at [Fe/H] ≤ −3) stars of the Galactic halo is still a matter of debate.Aims.In this paper, we explore this problem by putting our stochastic chemical evolution model in the hierarchical clustering framework, with the aim of explaining the observed spread in the halo.Methods.We compute the chemical enrichment of Eu occurring in the building blocks that have possibly formed the Galactic halo. In this framework, the enrichment from neutron star mergers can be influenced by the dynamics of the binary systems in the gravitational potential of the original host galaxy. In the least massive systems, the neutron stars can merge outside the host galaxy and so only a small fraction of newly produced Eu can be retained by the parent galaxy itself.Results.In the framework of this new scenario, the accreted merging neutron stars are able to explain the presence of stars with sub-solar [Eu/Fe] ratios at [Fe/H] ≤ −3, but only if we assume a delay time distribution for merging of the neutron stars ∝t−1.5. We confirm the correlation between the dispersion of [Eu/Fe] at a given metallicity and the fraction of massive stars which give origin to neutron star mergers. The mixed scenario, where both neutron star mergers and magneto-rotational supernovae do produce Eu, can explain the observed spread in the Eu abundance also for a delay time distribution for mergers going either as ∝t−1or ∝t−1.5.
A decomposition of book structure through ousiometric fluctuations in cumulative word-time
Authors: Fudolig Mikaela Irene , Alshaabi Thayer , Cramer Kathryn , Danforth Christopher M. , Dodds Peter Sheridan 
Published: April 2023

AbstractWhile quantitative methods have been used to examine changes in word usage in books, studies have focused on overall trends, such as the shapes of narratives, which are independent of book length. We instead look at how words change over the course of a book as a function of the number of words, rather than the fraction of the book, completed at any given point; we define this measure as “cumulative word-time”. Using ousiometrics, a reinterpretation of the valence–arousal–dominance framework of meaning obtained from semantic differentials, we convert text into time series of power and danger scores, with time corresponding to cumulative word-time. Each time series is then decomposed using empirical mode decomposition into a sum of constituent oscillatory modes and a non-oscillatory trend. By comparing the decomposition of the original power and danger time series with those derived from shuffled text, we find that shorter books exhibit only a general trend, while longer books have fluctuations in addition to the general trend. These fluctuations typically have a period of a few thousand words regardless of the book length or library classification code but vary depending on the content and structure of the book. Our findings suggest that, in the ousiometric sense, longer books are not expanded versions of shorter books, but rather are more similar in structure to a concatenation of shorter texts. Further, they are consistent with editorial practices that require longer texts to be broken down into sections, such as chapters. Our method also provides a data-driven denoising approach that works for texts of various lengths, in contrast to the more traditional approach of using large window sizes that may inadvertently smooth out relevant information, especially for shorter texts. Altogether, these results open up avenues for future work in computational literary analysis, particularly the possibility of measuring a basic unit of narrative.
Challenges and opportunities to build quantitative self-confidence in biologists
Authors: Cuddington Kim , Abbott Karen C , Adler Frederick R , Aydeniz Mehmet , Dale Rene , Gross Louis J , Hastings Alan , Hobson Elizabeth A , Karatayev Vadim A , Killion Alexander , Madamanchi Aasakiran , Marraffini Michelle L , McCombs Audrey L , Samyono Widodo , Shiu Shin-Han , Watanabe Karen H , White Easton R 
Published: April 2023

Abstract
New graduate students in biology programs may lack the quantitative skills necessary for their research and professional careers. The acquisition of these skills may be impeded by teaching and mentoring experiences that decrease rather than increase students’ beliefs in their ability to learn and apply quantitative approaches. In this opinion piece, we argue that revising instructional experiences to ensure that both student confidence and quantitative skills are enhanced may improve both educational outcomes and professional success. A few studies suggest that explicitly addressing productive failure in an instructional setting and ensuring effective mentoring may be the most effective routes to simultaneously increasing both quantitative self-efficacy and quantitative skills. However, there is little work that specifically addresses graduate student needs, and more research is required to reach evidence-backed conclusions.
Leg Ulcer Pathway Acceleration (LUPA) study
Authors: Livingstone Vanessa , Johnson Oscar , Peta Sujith , Mengtsu Azeb , Quintana Belen , Moyna Cory , Hunter Caroline , Thulasidasan Narayanan , Black Stephen A 
Published: April 2023

Abstract

Background
Leg ulcers are common, costly, and significantly impair quality of life, but their management is variable and associated with considerable delays in healing. The aim of this study was to design an accelerated leg ulcer care pathway in a community and hospital setting to improve patient outcomes.

Methods
A new referral pathway was developed using a series of healthcare professional and patient interviews, focus groups, and stakeholder workshops. The referral pathway, investigation and treatment protocols were further informed by clinical guidelines to develop the Leg Ulcer Pathway Acceleration care pathway. The outcomes of a consecutive series of patients enrolled in the Leg Ulcer Pathway Acceleration care pathway were compared with the outcomes of patients from a historical leg ulcer cohort from the same community and hospital setting.

Results
A total of 110 eligible patients were enrolled and followed prospectively through the Leg Ulcer Pathway Acceleration care pathway. Their outcomes were compared with those of 183 patients with venous leg ulcers identified from existing hospital and community ulcer centres, and acting as the historical control group. The 110 patients in the Leg Ulcer Pathway Acceleration group consisted of 73 (66 per cent) men, had a mean(s.d.) age of 55.7(17.2) years, and had a median initial ulcer duration of 14.5 (i.q.r. 6–30) months. The 183 patients in the historical control group consisted of 119 (65 per cent) men, had a mean(s.d.) age of 56.4(17.2) years, and had a median initial ulcer duration of 13.5 (i.q.r. 6–47) months. Venous disease was treated in 67/110 (61 per cent) and deep venous disease was treated in 33/110 (30 per cent) of patients in the Leg Ulcer Pathway Acceleration cohort. In contrast, only 16/183 (8 per cent) of patients in the control group were treated for superficial venous insufficiency and 4/183 (2 per cent) of patients in the control group were treated for deep venous disease. Ulcer healing rates at 12 months were 80 and 20 per cent in the Leg Ulcer Pathway Acceleration group and the control group respectively (P &lt; 0.001). Adjusted for baseline characteristics, the OR for a healed ulcer at 12 months was 21.21 (95 per cent c.i.. 11.32 to 42.46) (P &lt; 0.001).

Conclusion
The introduction of an accelerated leg ulcer care pathway significantly improves ulcer healing when compared with historical controls.
How to critically appraise a systematic review: an aide for the reader and reviewer
Authors: Frewen John , de Brito Marianne , Pathak Anjali , Barlow Richard , Williams Hywel C 
Published: April 2023

Abstract
The number of published systematic reviews has soared rapidly in recent years. Sadly, the quality of most systematic reviews in dermatology is substandard. With the continued increase in exposure to systematic reviews, and their potential to influence clinical practice, we sought to describe a sequence of useful tips for the busy clinician reader to determine study quality and clinical utility. Important factors to consider when assessing systematic reviews include: determining the motivation to performing the study, establishing if the study protocol was prepublished, assessing quality of reporting using the PRISMA checklist, assessing study quality using the AMSTAR 2 critical appraisal checklist, assessing for evidence of spin, and summarizing the main strengths and limitations of the study to determine if it could change clinical practice. Having a set of heuristics to consider when reading systematic reviews serves to save time, enabling assessment of quality in a structured way, and come to a prompt conclusion of the merits of a review article in order to inform the care of dermatology patients.
Topical steroid withdrawal: an emerging clinical problem
Authors: Brookes Tenzin Sung-rab , Barlow Richard , Mohandas Padma , Bewley Anthony 
Published: April 2023

Abstract

Background
Topical steroid withdrawal (TSW) is a newly described disease characterized by erythema and burning following discontinuation of prolonged use of mid- to high-potency topical corticosteroids. No consensus diagnostic criterion exists. TSW is frequently interpreted as flaring of the underlying disorder or contact allergy to topical treatment.

Objectives
To better characterize TSW symptomatology, detail our experience with management and assess the proportion of patients who pursue nonconventional management.

Methods
A retrospective review of case notes collected from our multidisciplinary service between January 2019 and June 2021 was carried out to identify patients presenting with TSW.

Results
Nineteen cases of TSW were identified, 15 in females and 4 in males. The majority were &lt; 35 years old. Eighteen had atopic dermatitis. The most frequently reported features were redness, skin pain (typically ‘burning’), skin sensitivity, excessive skin flaking, insomnia and severe itching. There was a high burden of anxiety and depression, with three patients expressing suicidal thoughts. Nonconventional treatments were pursued by approximately half the cohort, some of whom sought private consultation with international dermatologists. Improvements were noted in the context of open psychodermatology consultations with an earlier introduction of conventional management options.

Conclusions
Many patients report dismissal by dermatology healthcare professionals, often driving them to seek help from unregulated online sources, heightening the burden of mental, social and physical morbidity. Dermatology healthcare professionals need to be aware of TSW and offer support with shared decision-making when considering treatments.
Atopic dermatitis in skin of colour. Part 2: considerations in clinical presentation and treatment options
Authors: Gan Christian , Mahil Satveer , Pink Andrew , Rodrigues Michelle 
Published: April 2023

AbstractRecent advances in atopic dermatitis (AD) present the condition as a heterogeneous disease of distinct endotypes across ethnic groups. AD in people with skin of colour may appear psoriasiform, lichenoid, scaly or papular, with a violaceous colour and there is a higher prevalence of post-inflammatory dyspigmentation compared with affected individuals of White ethnicity. These differences in clinical presentation may limit the use of AD assessment tools in people with skin of colour, leading to the potential for misdiagnosis and underestimation of severity, particularly in relation to assessment of erythema. Recent targeted therapies for AD have been studied in multiple ethnic groups; however, ethnicity-based subgroup analysis is often not performed. Further research is required to understand whether treatment responses or safety may differ among ethnic groups.
Multimodal evidence for predictive coding in sentence oral reading
Authors: Zhao Bin , Zhang Gaoyan , Wang Longbiao , Dang Jianwu 
Published: April 2023

Abstract
Sentence oral reading requires not only a coordinated effort in the visual, articulatory, and cognitive processes but also supposes a top-down influence from linguistic knowledge onto the visual-motor behavior. Despite a gradual recognition of a predictive coding effect in this process, there is currently a lack of a comprehensive demonstration regarding the time-varying brain dynamics that underlines the oral reading strategy. To address this, our study used a multimodal approach, combining real-time recording of electroencephalography, eye movements, and speech, with a comprehensive examination of regional, inter-regional, sub-network, and whole-brain responses. Our study identified the top-down predictive effect with a phrase-grouping phenomenon in the fixation interval and eye-voice span. This effect was associated with the delta and theta band synchronization in the prefrontal, anterior temporal, and inferior frontal lobes. We also observed early activation of the cognitive control network and its recurrent interactions with the visual-motor networks structurally at the phrase rate. Finally, our study emphasizes the importance of cross-frequency coupling as a promising neural realization of hierarchical sentence structuring and calls for further investigation.
Diapause of the Western cherry fruit fly, Rhagoletis indifferens (Diptera: Tephritidae): metabolic rate and overwintering adaptations
Authors: Neven Lisa G 
Published: April 2023

Abstract
The Western cherry fruit fly, Rhagoletis indifferens (Curran), is a Tephritid fly in the Pacific Northwest and is known to infest native bitter cherry, Prunus emarginata (Douglas ex Hooker), which is distributed throughout the Cascade Mountain range. This species occupies temperate to alpine climates and exhibits overwintering adaptations of diapause and supercooling. Isothermal and differential scanning calorimetry were used to determine the effects of diapause chilling duration and post-chilling warm rearing on the metabolic rate and supercooling point of R. indifferens. Previous studies have included the effects of chilling duration on post-diapause development and emergence as well as on the levels of metabolic reserves. Metabolic rate of R. indifferens, was used to calculate the ability of this species to remain in diapause for more than 1 yr as well as predicting the potential effects of climate change on the future abundance and distribution. It was determined that R. indifferens could diapause for more than 1 yr based on the levels of metabolic reserves and metabolic rate.
EJE Prize 2023: genes on steroids—genomic control of hepatic metabolism by the glucocorticoid receptor
Authors: Quagliarini Fabiana , Makris Konstantinos , Friano Marika E , Uhlenhaut Nina Henriette 
Published: April 2023

AbstractGlucocorticoids are essential hormones produced by the adrenal cortex with prominent circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis through coordinated activities that control the major pathways of energy metabolism. Glucocorticoids activate the glucocorticoid receptor (GR), a nuclear hormone receptor that regulates the transcription of hundreds of genes in response to ligand. This review aims to provide a comprehensive overview of glucocorticoid receptor signaling impact on glucose, amino acid, and lipid metabolism in the liver. We integrate fundamental and current findings elucidating key GR-regulated pathways from a physiologic, biochemical, and molecular point-of-view. Here, we focus on the transcriptional regulation of well-characterized hepatic GR target genes, and on those GR co-factors that coordinate nutritional and hormonal signals.
Intra-household risk perceptions and climate change adaptation in sub-Saharan Africa
Authors: Ginbo Tsegaye , Hansson Helena 
Published: April 2023

Abstract
We examine the effects of spouses’ climate risk perceptions (CRPs), defined by their beliefs about unfavourable climatic events and associated damages, on climate change adaptation (CCA) and the observed gender gap in adaptation. Our analysis uses the intra-household data collected by independent interviews with 1,274 female and male spouses in Kenya, Uganda and Senegal. By addressing the CRP endogeneity issue using the exogenous weather shocks during data collection months as instruments, we find that a higher CRP of both female and male spouses increases their probability of adopting CCA strategies. We also find that a higher CRP of female spouses reduces the adaptation gap by increasing their relative adoption of soil and water conservation practices. Our results highlight the importance of understanding gender-differentiated behavioural and economic factors to design effective climate policy interventions.
Changes in self-rated physical and mental health and life satisfaction associated with opioid and potentially inappropriate opioid prescribing in primary care older adults
Authors: Pitrou Isabelle , D’Aiuto Carina , Lunghi Carlotta , Guénette Line , Berbiche Djamal , Bertrand Karine , Vasiliadis Helen-Maria 
Published: April 2023

Abstract

Objective
To examine changes in life satisfaction and physical and mental health associated with opioid and potentially inappropriate opioid prescribing (PIOP) among older adults.

Methods
Secondary data analysis from the Étude sur la Santé des Aînés (ESA)-Services study. The sample consisted of 945 older adults recruited in primary care with available health survey information linked to administrative medical record data. The exposure of interest was categorized as no prescription, opioid prescription, and PIOP, defined using the Beers criteria. Outcomes were self-rated physical health, mental health, and life satisfaction measured at baseline and at a 3-year follow-up. Generalized estimating equations were used to examine 3-year changes in outcomes as a function of opioid prescribing. Analyses were adjusted for covariates relating to health, psychosocial, and sociodemographic factors as well as duration/frequency of opioid prescribing. Analyses were conducted in the overall sample and in non-cancer patients.

Results
The sample had an average age of 73.1 years; the majority was Canadian-born (96.3%) while females made up over half (55.4%) the sample. Compared to not receiving an opioid prescription, PIOP was associated with a deterioration in physical health (ORadjusted = 0.65; 95%CI = 0.49, 0.86), but not mental health and life satisfaction. In non-cancer patients, PIOP was associated with poorer physical health (ORadjusted = 0.59; 95%CI = 0.40, 0.87) and opioid prescribing was marginally associated with improved life satisfaction (ORadjusted = 1.58; 95%CI = 0.96, 2.60).

Conclusion
PIOP was associated with a deterioration in physical health. Patient-centred chronic pain management and the effect on health and well-being require further study in older adults.