bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability of COVID‐19 vaccination in Chinese children aged 3–7 years with bronchopulmonary dysplasia
Authors: Wang Dan , Li Li , Cao Jingke , Hu Siqi , Liu Changgen , Feng Zhichun , Li Qiuping 
Published: January 2023

AbstractObjectivesTo describe the status of coronavirus disease 2019 (COVID‐19) vaccination with inactivated vaccines BBIBP‐CorV and CoronaVac in Chinese children aged 3–7 years with bronchopulmonary dysplasia (BPD), and explore factors influencing vaccination and reasons for nonvaccination.MethodsThis cross‐sectional study involving parents of 397 BPD children aged 3–7 years was conducted through WeChat or follow‐up telephone interviews using a standardized questionnaire form. Factors influencing COVID‐19 vaccination were explored by using modified Poisson regression models.ResultsThe overall COVID‐19 vaccination rate was 69.0% (95% confidence interval: 64.3%–73.4%). COVID‐19 vaccination was less likely to be accepted in children whose mothers had a relatively high educational background (university and above), who lived in urban areas and had a low birth weight (<1 kg), a history of hospitalization for lung diseases in the past 12 months, and intellectual disability. Conversely, kindergarten students and children from families with an annual income of >300,000 CNY (41,400 USD) were more likely to accept vaccination. Adverse reactions occurred in 13/274 children (4.7%) within 10 days after vaccination. With respect to reasons of not accepting COVID‐19 vaccination, 95 parents (77.2%) worried about the adverse reactions, and 17 parents (13.8%) refused vaccination on the excuse of not being convenient to go to the vaccination station or not knowing where to get the vaccines.ConclusionsThe COVID‐19 vaccination rate in BPD children aged 3–7 years needs to be further improved in China. Continuous efforts are required to monitor postvaccination adverse reactions in BPD children, and make vaccination more convenient and accessible.
Home‐based video assessment of ease of movement for patients with Duchenne: Interviews with physical therapists to select movement tasks
Authors: Contesse Marielle G. , Hodges Jason , Staunton Hannah , Lowes Linda P. , Elmankabadi Bassem , Elder Sonya J. , Ormazabal Maitea Guridi , Dalle Pazze Laura , Leffler Mindy G. 
Published: January 2023

AbstractBackground and PurposePatients with Duchenne muscular dystrophy (DMD) change their movement patterns to compensate for muscle weakness. The Duchenne Video Assessment (DVA) measures ease of movement through evaluation of compensatory movements. The DVA directs caregivers to video record patients performing home‐based movement tasks using a mobile application, and DVA‐certified physical therapists evaluate the videos using scorecards with prespecified compensatory movement criteria. Two qualitative interview studies were conducted to select movement tasks for the DVA that are relevant to patients with DMD and able to reflect changes in function.MethodsQualitative interviews with eligible physical therapists were conducted remotely. Physical therapists were asked to spontaneously suggest movement tasks prior to evaluating specific movement tasks selected a priori. Analysts conducted a content analysis to investigate whether movement tasks selected a priori were confirmed as relevant to the population of interest and able to show changes in function.ResultsThe studies included five physical therapists to select tasks for ambulatory patients with DMD and six for non‐ambulatory patients. For an ambulatory population, all five experts confirmed Climb Five Stairs, Run, Stand Up from Sitting, Sit Up from Supine, and Jump Forward, and four (80%) confirmed Walk as relevant and able to show functional changes. For a non‐ambulatory population, all six experts confirmed Eat 10 Bites, Roll Over in Bed, Shift Weight in Bed, Take T‐Shirt Off, Put T‐Shirt On, Put Arms on Armrest, and Reach Across Table to Grab Cell Phone, and five (83%) confirmed Raise Hands Above Head as relevant and able to show functional changes.DiscussionPhysical therapists confirmed the DVA movement tasks as relevant to patients with DMD and able to reflect changes in function. The use of the DVA in clinical trials provides an opportunity to collect data not seen in clinic and reduce travel burden for families.
Quantification of carboxylate‐bridged di‐zinc site stability in protein due ferri by single‐molecule force spectroscopy
Authors: Wang Zhiyi , Wang Mengdie , Zhao Zhongxin , Zheng Peng 
Published: January 2023

AbstractCarboxylate‐bridged diiron proteins belong to a protein family involved in different physiological processes. These proteins share the conservative EXXH motif, which provides the carboxylate bridge and is critical for metal binding. Here, we choose de novo‐designed single‐chain due ferri protein (DFsc), a four‐helical protein with two EXXH motifs as a model protein, to study the stability of the carboxylate‐bridged di‐metal binding site. The mechanical and kinetic properties of the di‐Zn site in DFsc were obtained by atomic force microscopy‐based single‐molecule force spectroscopy. Zn‐DFsc showed a considerable rupture force of ~200 pN, while the apo‐protein is mechanically labile. In addition, multiple rupture pathways were observed with different probabilities, indicating the importance of the EXXH‐based carboxylate‐bridged metal site. These results demonstrate carboxylate‐bridged di‐metal site is mechanically stable and improve our understanding of this important type of metalloprotein.
Psoralen induces liver injury and affects hepatic bile acids metabolism in female and male C57BL/6J mice
Authors: Chen Meng‐ying , Wang Qin , Meng Zhao‐jun , Men Wei‐jie , Huang Ju‐yang , Yu Bin , Zhou Kun 
Published: February 2023

AbstractPsoralen is a major component of Fructus Psoraleae that could induce liver injury. In this study, C57BL/6J mice were administered with psoralen at doses of 80 mg/kg for 3, 7 and 14 days. Blood and liver samples were collected for serum biochemistry and histopathology examinations, respectively. Psoralen led to liver injury with significantly increased liver weight and liver coefficient and up regulated serum ALT, AST and TG but down regulated serum TC and TP. The expression of bile acid‐associated transporters and enzymes was detected by western blot, and the results showed that psoralen significantly down‐regulates the expressions of CYP7A1, CYP27A1, BSEP and OSTα protein while up‐regulates the expressions of HMGCR and FASN, resulting in the obstacles of bile acid efflux in the liver. The contents of 24 kinds of bile acids in the liver were measured by LC–MS/MS, and the results showed that psoralen led to the accumulation of unconjugated bile acids in the liver, such as ALCA and CA, which were more severe in male mice than female mice. It was indicated that psoralen may disrupt the balance of bile acid metabolism by inhibiting the expression of the efflux transporter, which then leads to liver damage.
Met Office MOGREPS‐G initialisation using an ensemble of hybrid four‐dimensional ensemble variational (En‐4DEnVar) data assimilations
Authors: Inverarity G. W. , Tennant W. J. , Anton L. , Bowler N. E. , Clayton A. M. , Jardak M. , Lorenc A. C. , Rawlins F. , Thompson S. A. , Thurlow M. S. , Walters D. N. , Wlasak M. A. 
Published: February 2023

AbstractThe Met Office Global and Regional Ensemble Prediction System–Global (MOGREPS‐G) used an ensemble transform Kalman filter (ETKF) to perturb its initial conditions from its operational implementation in September 2008 until December 2019. In 2019, MOGREPS‐G became the first operational atmospheric ensemble to apply hybrid four‐dimensional ensemble variational data assimilation (En‐4DEnVar) to each of the 44 perturbed ensemble members. Other enhancements have also been added, including to the inflation used to improve ensemble spread. The combined impact of these changes on ensemble forecasts is overwhelmingly positive but initially more neutral for deterministic forecasts, which also use the ensemble to represent flow‐dependent forecast errors in their hybrid data assimilation updates. The latter result is not a surprise, because the deterministic forecast's hybrid data assimilation was initially weighted more strongly to the modelled stationary covariance component and not optimised to take full advantage of the upgraded ensemble. A subsequent operational upgrade in December 2020 has introduced shifting in addition to lagging to exploit the ensemble better in the deterministic forecast's hybrid data assimilation by including ensemble members from a previous cycle and also from adjacent forecast lead times to augment the ensemble without having to run additional forecasts. More weight has since been given to the ensemble in the deterministic forecast's hybrid data assimilation in May 2022. A key motive for adopting hybrid 4DEnVar in MOGREPS‐G is to reduce maintenance overheads by virtue of sharing much of the deterministic forecast system's data assimilation code. This also enables the ensemble to assimilate almost all observation types used by the deterministic forecast. The updated system also exploits parallelism better so as to be fast enough for operational use, despite assimilating more observations and being more computationally expensive than the Met Office's ETKF.
Pneumatosis intestinalis with free air in the abdominal cavity caused by nintedanib
Authors: Sakamoto Naho , Kato Motoyasu , Ohni Toshihiko , Terayama Yuriko , Nakazawa Shun , Okamoto Shouichi , Ito Jun , Takahashi Kazuhisa 
Published: January 2023

Key messageThis is the first case confirmed the association between PI development and nintedanib by the reproducibility of PI development. In patients taking a combination treatment with corticosteroid and nintedanib, clinicians should be careful regarding the development of PI although the patient improved only after discontinuation of nintedanib treatment.
Adaptive fuzzy predefined‐time fault‐tolerant control for third‐order heterogeneous vehicular platoon systems
Authors: Zhao Yongyan , Li Yongming 
Published: January 2023

AbstractThis article investigates an adaptive fuzzy predefined‐time fault‐tolerant control problem for third‐order heterogeneous vehicular platoon systems (HVPS) with actuator faults. For the purpose of approximating the unknown nonlinear functions, fuzzy logic systems (FLSs) are used. Because the maximum acceleration changes as a result of actuator faults, a quadratic spacing strategy including fault factor is considered. A predefined‐time fault‐tolerant controller is designed to address the impact of actuator faults. The proposed method makes use of the non‐singular terminal sliding mode control (SMC) approach and predefined time stability criterion. Individual vehicle stability, string stability (SS), and traffic flow stability are all guaranteed in a predefined time. Finally, simulations illustrate the usefulness of the given results.
Physics curriculum in upper secondary schools: What leading physicists want
Authors: Žák Vojtěch , Kolář Petr 
Published: January 2023

AbstractThis paper explores the views of leading Czech physicists regarding a physics curriculum for upper secondary schools. This paper presents the first part of an effort to define starting points for a new physics curriculum in Czechia (subsequent phases would analyze the opinions of other scientists, education experts, and physics teachers regarding the physicists' ideas) and create a new physics textbook for upper secondary schools. The methodology was inspired especially by the objectivist grounded theory. We conducted in‐depth interviews about the upper secondary physics curriculum with 29 leading Czech physicists and identified 56 ideas (categories) that they agreed on (according to the interview analysis). Subsequently, a questionnaire was created based on these 56 ideas. Two years later, the same group of physicists were asked to express their opinions on the ideas on a 7‐point Likert scale. The new survey sought to clarify the relevance and permanence of the ideas, and the physicists' willingness to collaborate on constructing a physics curriculum for upper secondary schools. Four core categories—students, physics, context, and math—were identified through a comparison of the relevance of the ideas. Additionally, we compared the questionnaire answers of a physicist with their opinions during the interview and identified 43 ideas as permanent (in the 2‐year interval). Surprisingly, 26 of the 29 researchers in the initial study completed the subsequent questionnaire survey and 13 among these expressed their willingness to contribute to the development of a physics textbook for upper secondary schools.
Design, Synthesis, Antimicrobial Evaluation, Antioxidant Studies, and Molecular Docking of Some New 1H‐Benzimidazole Derivatives
Authors: Kus Canan , Ozer Ezgi , Osman Hind M. , Sozudonmez Fatma , Simsek Duygu , Altanlar Nurten , Basaran Rahman , Guven Naile M. , Kocyigit Aysegul , Can‐Eke Benay 
Published: February 2023

AbstractThe goal of this study is to synthesize and test a series of novel benzimidazole derivatives (3 a–3 q, 4 a, 4 b) for antimicrobial and antioxidant activity. The compounds were tested for antimicrobial activity in vitro using the macro dilution broth method. The antioxidant activity of the synthesized compounds was evaluated using assay of Lipid peroxidation (LP) level by measuring the formation of 2‐thiobarbituric acid reactive substances (TBARS) and 7‐Ethoxyresorufin O‐deethylase (EROD) activity. Only the compound 3 m demonstrated significant antimicrobial activity against all of the microorganisms tested. The LP level of compound 3 m (5.20±0.28, 68 %) was comparable to that of standard BHT (5.68±0.22, 65 %). Compounds 3 i (11 %, 28 %) and 3 m (13 %, 32 %) are the most active compounds on microsomal EROD activity and LP levels which are better than standard caffeine (15 %) and BHT (35 %), respectively. Also compounds 3 g (20 %), and 4 b (28 %) have much better LP levels than BHT (35 %). Compound 3 m exhibited high docking energies scores comparing with reference drugs when docked with bacterial Penicillin‐Binding Protein 3 and 4, sterol 14 α‐demethylase of C. albicans and urate oxidase enzyme.
N1‐Methylthiomethylation of (8‐Aza)6‐Chloropurine with DMSO through the Pummerer Rearrangement
Authors: Wang Chenxing , Xu Jiaxi , Chen Ning 
Published: February 2023

AbstractN1‐[(Methylthio)methyl] hypoxanthines and aza hypoxanthines were efficiently prepared from 6‐chloropurines/azapurines and DMSO under microwave irradiation. DMSO was employed as a readily available and atom‐economic methylthiomethylating reagent and solvent without any other activator. The mechanistic investigations demonstrate that the reaction proceeded via sequential SNAr reaction and the Pummerer rearrangement. The current protocol provides an effective strategy for the synthesis of various N1‐[(methylthio)methyl] (8‐aza)hypoxanthines.
Highly Selective Reduction of Carbonyl Compounds and O‐Acetylation of Arylalcohols in the Presence of a Nickel Ion‐Containing 1,4‐Diazabicyclo[2.2.2]octane (DABCO)‐Based Ionic Liquid
Authors: Seyedi Narges , Nazemi‐Nasyrmahale Leyla , Shirini Farhad , Tajik Hassan 
Published: February 2023

AbstractDuring this study, an easy procedure is presented for the preparation of a new nickel ion‐containing DABCO based ionic liquid. The prepared reagent was characterized using FT‐IR, FESEM, EDX, XRD, ICP‐OES, TGA and DRS analyses. In continue the catalytic activity of this reagent which is formulated as [C4(DABCO)2].NiCl4 was investigated in the reduction of a variety of carbonyl compounds to their corresponding alcohols with NaBH4. The promoting ability of this catalyst was also confirmed in the acetylation of alcohols with CH3COCl. All reactions were carried out in short times with high to excellent yields. The catalyst was also recoverable and reusable in the studied reactions.
Single‐Step Oxidation of Low‐Concentration Methane to Methanol in the Gaseous Phase Using Ceria‐Based Iridium‐Copper Catalysts
Authors: Wu Mingwei , Li Wenzhi , Zhu Chen , Wu Wenjian , Zhang Lulu , Zheng Taimin , Fu Yan , Yuan Liang 
Published: February 2023

AbstractSingle‐step conversion of methane to methanol in the gaseous phase is required for high value added application of methane and environmental protection, but it is challenging. Here, direct oxidation of methane to methanol under gaseous condition on iridium promoted Cu/CeO2 catalyst, prepared using a sol‐gel method, is investigated. The addition of iridium can effectively upgrade the redox properties and oxygen storage capacity due to intense metal interaction, stimulating a prominent catalytic performance for methane conversion to methanol on Cu−Ir@CeO2 catalyst. Approximately 26.2 μmol/gcat methanol yield and 68 % methanol selectivity are achieved on the trimetallic 5Cu0.5Ir@CeO2 catalyst at 550 °C in 2 h. Consequences of the analysis of XRD, SEM, HRTEM, Raman, FI‐IR and XPS demonstrate that highly‐dispersed Ir and Cu species are uniformly distributed on CeO2 surface, and partial Cu or Ir atoms replace Ce4+ in CeO2 lattice due to the metal interaction in the colloidal structure, which can impact the catalyst's electronic properties. H2 temperature‐programmed reduction (H2‐TPR) and CH4 temperature‐programmed desorption (CH4‐TPD) results disclose that the unique ternary surface exhibits excellent redox properties and strong adsorption capacity for methane, which can activate the first C−H bond of methane to methyl species, and then react with OH− to form methanol. The good stability in cyclic operation is an additional attribute, rendering this type of catalyst a “front‐runner” in future catalyst development for direct methane‐to‐methanol. This composite catalyst design provides hope for developing ternary metal‐oxide catalysts for functionalization of methane.
Developing Superior Hydrophobic 3D Hierarchical Electrocatalysts Embedding Abundant Catalytic Species for High Power Density Zn–Air Battery
Authors: Zhao Dafu , Zhang Liping , Zuo Siyu , Lv Xiaowei , Zhao Meiyun , Sun Panpan , Sun Xiaohua , Liu Tianbiao Leo 
Published: January 2023

AbstractIt is essential but still challenging to design and construct inexpensive, highly active bifunctional oxygen electrocatalysts for the development of high power density zinc–air batteries (ZABs). Herein, a CoFe‐S@3D‐S‐NCNT electrocatalyst with a 3D hierarchical structure of carbon nanotubes growing on leaf‐like carbon microplates is designed and prepared through chemical vapour deposition pyrolysis of CoFe‐MOF and subsequent hydrothermal sulfurization. Its 3D hierarchical structure shows excellent hydrophobicity, which facilitates the diffusion of oxygen and thus accelerates the oxygen reduction reaction (ORR) kinetic process. Alloying and sulfurization strategies obviously enrich the catalytic species in the catalyst, including cobalt or cobalt ferroalloy sulfides, their heterojunction, core–shell structure, and S, N‐doped carbon, which simultaneously improve the ORR/OER catalytic activity with a small potential gap (ΔE = 0.71 V). Benefiting from these characteristics, the corresponding liquid ZABs show high peak power density (223 mW cm−2), superior specific capacity (815 mA h gZn−1), and excellent stability at 5 mA cm−2 for ≈900 h. The quasi‐solid‐state ZABs also exhibit a very high peak power density of 490 mW cm−2 and an excellent voltage round‐trip efficiency of more than 64%. This work highlights that simultaneous composition optimization and microstructure design of catalysts can effectively improve the performance of ZABs.
Ultrafast Charge‐Discharge Capable and Long‐Life Na3.9Mn0.95Zr0.05V(PO4)3/C Cathode Material for Advanced Sodium‐Ion Batteries
Authors: Wang Zhuangzhou , Cui Guijia , Zheng Qinfeng , Ren Xiangyu , Yang Qingheng , Yuan Siqi , Bao Xu , Shu Chaojiu , Zhang Yixiao , Li Linsen , He Yu‐Shi , Chen Liwei , Ma Zi‐Feng , Liao Xiao‐Zhen 
Published: February 2023

AbstractNa4MnV(PO4)3/C (NMVP) has been considered an attractive cathode for sodium‐ion batteries with higher working voltage and lower cost than Na3V2(PO4)3/C. However, the poor intrinsic electronic conductivity and Jahn–Teller distortion caused by Mn3+ inhibit its practical application. In this work, the remarkable effects of Zr‐substitution on prompting electronic and Na‐ion conductivity and also structural stabilization are reported. The optimized Na3.9Mn0.95Zr0.05V(PO4)3/C sample shows ultrafast charge‐discharge capability with discharge capacities of 108.8, 103.1, 99.1, and 88.0 mAh g−1 at 0.2, 1, 20, and 50 C, respectively, which is the best result for cation substituted NMVP samples reported so far. This sample also shows excellent cycling stability with a capacity retention of 81.2% at 1 C after 500 cycles. XRD analyses confirm the introduction of Zr into the lattice structure which expands the lattice volume and facilitates the Na+ diffusion. First‐principle calculation indicates that Zr modification reduces the band gap energy and leads to increased electronic conductivity. In situ XRD analyses confirm the same structure evolution mechanism of the Zr‐modified sample as pristine NMVP, however the strong ZrO bond obviously stabilizes the structure framework that ensures long‐term cycling stability.
Coordination Engineering of Defective Cobalt–Nitrogen–Carbon Electrocatalysts with Graphene Quantum Dots for Boosting Oxygen Reduction Reaction
Authors: Geng Di , Huang Yichao , Yuan Saifei , Jiang Yangyang , Ren Hao , Zhang Su , Liu Zheng , Feng Jing , Wei Tong , Fan Zhuangjun 
Published: January 2023

AbstractDeveloping efficient and robust metal–nitrogen–carbon electrocatalysts for oxygen reduction reaction (ORR) is of great significance for the application of hydrogen–oxygen fuel cells and metal–air batteries. Herein, a coordination engineering strategy is developed to improve the ORR kinetics and stability of cobalt–nitrogen–carbon (Co–N–C) electrocatalysts by grafting the oxygen‐rich graphene quantum dots (GQDs) onto the zeolite imidazole frameworks (ZIFs) precursors. The optimized oxygen‐rich GQDs‐functionalized Co–N–C (G‐CoNOC) electrocatalyst demonstrates an increased mass activity, nearly two times higher than that of pristine defective Co–N–C electrocatalyst, and retains a stability of 90.0% after 200 h, even superior to the commercial Pt/C. Comprehensive investigations demonstrate that the GQDs coordination can not only decrease carbon defects of Co–N–C electrocatalysts, improving the electron transfer efficiency and resistance to the destructive free radicals from H2O2, but also optimize the electronic structure of atomic Co active site to achieve a desired adsorption energy of OOH−, leading to enhanced ORR kinetics and stability by promoting further H2O2 reduction, as confirmed by theoretical calculations and experimental results. Such a coordination engineering strategy provides a new perspective for the development of highly active noble‐metal‐free electrocatalysts for ORR.