bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Associated Factors Of Preoperative Abnormal Electrocardiography Among Older Surgical Patients In Southern Ethiopia: Multicenter Cross-Sectional Study
Authors: Mossie Addisu , Getachew Hailemariam , Girma Timsel , Mulugeta Hailemariam , Destaw Belete , Besha Aschalew , Shiferaw Adanech 
Published: July 2023

Abstract

Background: The prevalence of abnormal electrocardiography (ECG) increases with aging, and these abnormalities may have an impact on anesthesia management.
Objective: The aim of this study was to determine the prevalence and associated factors of preoperative abnormal electrocardiography among older surgical patients at selected teaching hospitals in southern Ethiopia, from February 15 to June 15, 2022.
Methodology: A multicenter cross-sectional study was conducted on 246 elderly surgical patients. A binary logistic regression model was used, and a P-value < 0.05 was considered statistically significant.
Result: In the current study, 120 (48.78%) of older surgical patients had abnormal preoperative ECGs. In terms of severity, 44.16% were with major ECG abnormalities. The most common ECG abnormalities were left axis deviation, left ventricular hypertrophy, and ST segment changes. The presence of comorbidity (AOR=3.44, P =0.001), age ≥70 years (AOR=2.5, P=0.011), history of angina (AOR=5.9, P=0.011), history of smoking (AOR=5.07, P=0.024) and urban residency (AOR=1.89, P=0.039) were associated factors for an abnormal ECG.
Conclusion and recommendation: Our study showed that the prevalence of preoperative abnormal ECG increased with age, even in asymptomatic patients with no risk factors and younger than 65 years. Therefore, a preoperative ECG is advisable in all older patients.
Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism
Authors: Kostina-Bednarz Marianna , Płonka Joanna , Barchanska Hanna 
Published: July 2023

Abstract

Metabolic profiling offers huge potential to highlight markers and mechanisms in support of toxicology and pathology investigations during drug development. The main objective was to modify therapy with adamantane derivatives: amantadine and rimantadine, to increase their bioavailability and evaluate the influence of such therapy on drug metabolism using Saccharomyces cerevisiae as the model organism. In this study, the profile of endogenous metabolites of a model organism was measured and interpreted to provide an opportunity to investigate changes induced by treatment with amantadine and rimantadine. It was found that resveratrol supplementation synergistically enhanced the effects of amantadine treatment and increased rimantadine metabolism, potentially reducing side effects. The fingerprinting strategy was used as an efficient technique for qualitatively evaluating and monitoring changes in the profiles of endogenous components and their contents in a model organism. Chemometric tools were employed to find marker compounds that can be defined as characteristic indicators of a pharmacological response to a therapeutic intervention. An improved understanding of the mechanisms involved in drug effect and an increased ability to predict individual variations in the drug response of organisms will improve the treatment process and the development of new therapies.
Wearable technology mediated biofeedback to modulate spine motor control: a systematic review
Authors: Battis Aurora , Norrie Jarrett P. , McMaster Hannah , Beaudette Shawn M. 
Published: July 2023

Abstract

Background: Lower back pain (LBP) is a disability that affects a large proportion of the population and treatment for this condition has been shifting towards a more individualized, patient-centered approach. There has been a recent uptake in the utilization and implementation of wearable sensors that can administer biofeedback in various industrial, clinical, and performance-based settings. Despite this, there is a strong need to investigate how wearable sensors can be used in a sensorimotor (re)training approach, including how sensory biofeedback from wearable sensors can be used to improve measures of spinal motor control and proprioception.
Research Question: The purpose of this systematic review was to examine the wide range of wearable sensor mediated biofeedback frameworks currently being utilized to enhance spine posture and motor function.
Methods: A comprehensive systematic review was conducted in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA) across the following databases: Embase, PubMed, Scopus, Cochrane, and IEEEXplore. Articles related to wearable biofeedback and spine movement were reviewed dated from 1980 onwards. Extracted data was collected as per a predetermined checklist including the type, timing, trigger, location, and magnitude of sensory feedback being applied to the body.
Results: A total of 23 articles were reviewed and analysed. The most used wearable sensor to inform biofeedback were inertial measurement units (IMUs). Haptic (vibrotactile) feedback was the most common sensory stimulus. Most studies used an instantaneous online trigger to initiate sensory feedback derived based on information pertaining to gross lumbar angles or the absolute orientations of the thorax or pelvis.
Conclusions: This is the first study to review wearable sensor derived sensory biofeedback to modulate spine motor control. Although the type of wearable sensor and feedback were common, this study highlights the lack of consensus regarding the timing and structure of sensory feedback, suggesting the need to optimize any sensory feedback to a specific use case. The findings from this study help to improve the understanding surrounding the ecological utility of wearable sensor mediated biofeedback in industrial, clinical and performance settings to enhance the sensorimotor control of the lumbar spine.
Dynamics, Circuit Design, Feedback Control of a New Hyperchaotic System and Its Application in Audio Encryption
Authors: Fu ShiMing , Liu Juan , Cheng XueFeng 
Published: July 2023

Abstract
In this study, a new 4D hyperchaotic system is developed from the 3D Lü chaotic system. The dynamic characteristics of the proposed hyperchaotic system are analyzed using chaotic attractors, equilibrium point stability, Lyapunov exponents’ spectrum, and bifurcation diagrams. Additionally, a linear feedback control method is employed to design the feedback control of the hyperchaotic system. Then, the new hyperchaotic system is implemented using electronic workbench multisim and embedded hardware STM32, and the experimental results are compared with the numerical simulations, showing consistency between them. Finally, using the principle of cross-XOR operation, the audio encryption of hyperchaotic sequence was implemented on the embedded hardware STM32. The results show that the audio encryption scheme based on the hyperchaotic system is feasible, and the method is simple to implement, has nonlinear characteristics and certain algorithm complexity, which can be applied to audio encryption, image encryption, video encryption, and more.
Efficacy of the latest new stimulation patterns of spinal cord stimulation for intractable neuropathic pain comparing to conventional stimulation: Study protocol for a clinical trial
Authors: Tanei Takafumi , Maesawa Satoshi , Nishimura Yusuke , Nagashima Yoshitaka , Ishizaki Tomotaka , Ando Masahiko , Kuwatsuka Yachiyo , Hashizume Atsushi , Kurasawa Shimon , Saito Ryuta 
Published: July 2023

Abstract
Background: Spinal cord stimulation (SCS) is one of the neuromodulation therapies for chronic neuropathic pain. The conventional paresthesia-based SCS involves the application of tonic stimulation that induces a sense of paresthesia. Recently, new SCS stimulation patterns without paresthesia have been developed. Differential target multiplexed (DTM) stimulation and fast-acting subperception therapy (FAST) stimulation are the latest paresthesia-free SCS patterns.
Methods: A single-center, open-label, crossover, randomized trial to investigate the superiority of SCS using the latest new stimulation patterns over conventional tonic stimulation for neuropathic pain is planned. This study consists of two-steps: SCS trial (first step) and SCS system implantation (second step). In the SCS trial, participants will be randomly assigned to 4 groups receiving stimulation, including tonic, DTM, and FAST. Each stimulation will then be performed for 2 days, and a visual analog scale (VAS) for pain will be evaluated before and after each stimulation pattern. A stimulation-off period for 1 day is set between each stimulation pattern to washout the residual previous stimulation effects. Pain improvement is defined as more than 33% reduction on the pain VAS. The primary analysis will compare pain improvement between the new stimulation patterns and the conventional tonic stimulation pattern in the SCS trial. The secondary outcomes will be evaluated as follows: 1) the relationships between causative disease and improvement rate by each stimulation pattern; 2) comparison of pain improvement between the DTM and FAST stimulation patterns in all cases and by causative disease; 3) changes in assessment items preoperatively to 24 months after implantation; 4) preoperative factors associated with long-term effects defined as continuing for more than 12 months; and 5) adverse events related to this study 3 months after implantation.
Discussion: This study aims to clarify the effectiveness of the latest new stimulation patterns compared to the conventional tonic stimulation. In addition, which stimulation pattern is most effective for which kind of causative disease will be clarified.
Trial registration: Japan Registry of Clinical Trials (jRCT) 1042220094. Registered on 21 November 2022, and last modified on 6 January 2023. jRCT is an approved member of the Primary Registry Network of WHO ICTRP.
Identification of a Novel Macrophage-Related Prognostic Signature in Colorectal cancer
Authors: Lin Dongfa , Zheng Tingjin , Huang Shangyuan , Hua Shuang , Liu Rui , Guan Shuwen , Zhang Zhishan 
Published: July 2023

Abstract
Colorectal cancer (CRC) is one of the most prevalent and deadliest illnesses all around the world. Growing proofs demonstrate that tumor-associated macrophages (TAMs) are of critical importance in CRC pathogenesis, but their mechanisms remain yet unknown. The current research was designed to recognize underlying biomarkers associated with TAMs in CRC. We screened macrophage-related gene modules through WGCNA, selected hub genes utilizing the LASSO algorithm and COX regression, and established a model. External validation was performed by expression analysis using datasets GSE14333, GSE74602, and GSE87211. After validating the bioinformatics results using real-time quantitative reverse transcription PCR, we identified SPP1, C5AR1, MMP3, TIMP1, ADAM8 as potential biomarkers associated with macrophages in CRC.
Association between body mass index and three-year outcome of acute myocardial infarction
Authors: Park Soyoon , Kim Dae-Won , Lee Myunhee , Lee Kyusup , Park Mahn-Won , Chang Kiyuk , Jeong Myung Ho 
Published: July 2023

Abstract
Introduction:
Body mass index (BMI), as an important risk factor related to metabolic disease. However, in some studies higher BMI was emphasized as a beneficial factor in the clinical course of patients after acute myocardial infarction (AMI) in a concept known as the “BMI paradox.” The purpose of this study was to investigate how clinical outcomes of patients treated for AMI differed according to BMI levels.
Methods
A total of 10,566 patients in the Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) from May 2010 to June 2015 were divided into three BMI groups (group 1: BMI < 22 kg/m2, group 2: ≥ 22 and < 26 kg/m2, and group 3: ≥ 26 kg/m2). The primary outcome was major adverse cardiac and cerebrovascular event (MACCE) at three years of follow-up.
Results
At one year of follow-up, the incidence of MACE in group 1 was 10.1% of that in group 3, with a hazard ratio (HR) of 2.27, and 6.5% in group 2, with an HR of 1.145. This tendency continued up to three years of follow-up.
Conclusion
The study demonstrated that higher BMI could exert a positive effect on the clinical outcomes of patients with AMI undergoing percutaneous coronary intervention (PCI).
Radio-frequency thermal-sheaths containing kappa distribution electrons and dust particles
Authors: Shihab M. , Elkamash I.S. 
Published: July 2023

Abstract
Hybrid fluid-kinetic models are adopted to investigate the collisionless plasma sheaths with κ-electron distribution and containing dust particles. A modified ensemble-in-spacetime model is utilized. The model is suitable for sheaths with non-Maxwellian electrons, such as, in DIII-D tokamak. In the intermediate radio-frequency regime, the flux and energy of ions are time-modulated within the sheath. Ions are not inertial-less. The value of κ affects the electron and ion density. Time-averaged electron and ion densities, the sheath edge position, and the area of the sheath voltage-sheath charge hysteresis loop increase by increasing the value of κ.The ion energy distribution is not sensitive to the κ distribution. Dust particles are charged with different negative charges based on their radius, their position within the sheath, the κ-electron distribution, and the sheath potential. Dust particles exhibit an oscillatory motion due to the interaction with the plasma and the gravitational fields.
Using anthropometric parameters to predict insulin resistance among patients without diabetes mellitus
Authors: Liu Jiajun , Jin Xueshan , Feng Ziyi , Huang Jieming 
Published: July 2023

Abstract

Background: Anthropometric parameters are widely used in the clinical assessment of hypertension, type 2 diabetes, and cardiovascular disease. However, few studies have compared the association between different anthropometric parameters and insulin resistance (IR). This study was aimed at investigating the relationship between 6 indicators, including body mass index (BMI), calf circumference (CC), arm circumference (AC), thigh circumference (TC), waist circumference (WC), waist-height ratio (WHtR), and IR.
Methods: Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was used to measure IR. Weighted linear regression was used to assess the relationship between different parameters and IR. The receiver operating characteristic curve (ROC) was employed to compare the strength of the relationship between different anthropometric parameters and IR.
Results: A total of 8,069 participants were enrolled in our study, including 4,873 without IR and 3,196 with IR. The weighted linear regression results showed that BMI, CC, AC, TC and WC were significantly correlated with IR, except WHtR. After adjusting for multiple confounding factors, we found that BMI, AC and WC were significantly positively correlated with IR, while TC was significantly negatively correlated with IR. Logistic regression results showed that a larger TC was associated with a decreased risk of IR. In addition, BMI and WC had similar areas under the curve (AUC: 0.780, 95% CI: 0.770-0.790; AUC: 0.774, 95% CI: 0.763-0.784, respectively), which were higher than TC and AC (AUC: 0.698, 95% CI: 0.687-0.710, AUC: 0.746, 95% CI: 0.735-0.757, respectively).
Conclusions: To our knowledge, this is the first study to report a negative correlation between TC and IR among patients without diabetes mellitus. Therefore, TC may be a new tool to guide public health and a clinical predictor of IR in non-diabetic patients.
Genomics of Plasmodium vivax in Colombia: evidence of local bottle-necking and inter-country connectivity in the Americas
Authors: Sutanto Edwin , Pava Zuleima , Echeverry Diego , Lopera-Mesa Tatiana , Montenegro Lidia Madeline , Yasnot-Acosta Maria , Benavente Ernest , Pearson Richard , Herrera Sócrates , Arévalo-Herrera Myriam , Trimarsanto Hidayat , Rumaseb Angela , Noviyanti Rintis , Kwiatkowski Dominic , Price Ric , Auburn Sarah 
Published: July 2023

Abstract
Colombia aims to eliminate malaria by 2030 but remains one of the highest burden countries in the Americas. Plasmodium vivax contributes half of all malaria cases, with its control challenged by relapsing parasitaemia, drug resistance and cross-border spread. Using 64 Colombian P. vivax genomes collected between 2013 and 2017, we explored diversity and selection in two major foci of transmission: Chocó and Córdoba. Open-access data from other countries were used for comparative assessment of drug resistance candidates and to assess cross-border spread. Across Colombia, polyclonal infections were infrequent (12%), and infection connectivity was relatively high (median IBD = 5%), consistent with low endemicity. Chocó exhibited a higher frequency of polyclonal infections (23%) than Córdoba (7%), although the difference was not significant (P = 0.300). Most Colombian infections carried double pvdhfr (95%) and single pvdhps (71%) mutants, but other drug resistance mutations were less prevalent (< 10%). There was no evidence of selection at the pvaat1 gene, whose P. falciparum orthologue has recently been implicated in chloroquine resistance. Global population comparisons identified other putative adaptations. Within the Americas, low-level connectivity was observed between Colombia and Peru, highlighting potential for cross-border spread. Our findings demonstrate the potential of molecular data to inform on infection spread and adaptation.
Integrative Methods Reveal Multiple Drivers of Diversification in Rice Paddy Snakes
Authors: Bernstein Justin M. , Voris Harold K. , Stuart Bryan L. , Karns Daryl R. , McGuire Jimmy A. , Iskandar Djoko T. , Riyanto Awal , Calderón-Acevedo Camilo A. , Brown Rafe M. , Gehara Marcelo , Soto-Centeno J. Angel , Ruane Sara 
Published: July 2023

Abstract
Divergence dating analyses in systematics provide a framework to develop and test biogeographic hypotheses regarding speciation. However, as molecular datasets grow from multilocus to genomic, sample sizes decrease due to computational burdens, and the testing of fine-scale biogeographic hypotheses becomes difficult. In this study, we use coalescent demographic models to investigate the diversification of poorly known rice paddy snakes from Southeast Asia (Homalopsidae: Hypsiscopus), which have conflicting dates of origin based on previous studies. We use coalescent modeling to test the hypothesis that Hypsiscopus diversified 2.5 mya during the Khorat Plateau uplift in Thailand. Additionally, we use ecological niche analyses to identify potential differences in the niche space of the two most widely distributed species in the past and present. Our results suggest Hypsiscopus diversified ~ 2.4 mya, supporting that the Khorat Plateau may have initiated the diversification of rice paddy snakes. We also find significant niche differentiation and shifts between species of Hypsiscopus, indicating that environmental differences may have sustained differentiation of this genus after the Khorat Plateau uplift. Our study expands on the diversification history of snakes in Southeast Asia, and highlights how results from smaller multilocus datasets can be useful in developing and testing biogeographic hypotheses alongside genomic datasets.
The Effect of Olanzapine through Antioxidant and Anti-Inflammation on the Hippocampus in the Asphyxial Cardiac Arrest Rat Model
Authors: Park Byung-Yong , Yoo Yeo-Jin , Kim Ryun-Hee , Jang Young-Jin , Lee Jun Ho , Kim Tae Hoon , Lee Youngkwan , Hwang Jeong Ho , Kim In-Shik , Hwang Hong Pil , Tae Hyun-Jin , Yoon Jae Chol , Shin Ha-Young , Kim So Eun 
Published: July 2023

Abstract
Introduction:
Cardiac arrest (CA) often leads to severe brain damage, resulting in neurological disorders and high mortality rates. Hypothermia treatment (HT) is commonly used in clinical practice after CA/cardio-pulmonary resuscitation (CA/CPR) because it has been shown to improve neurological outcomes and increase survival rates. Olanzapine, a medication known to induce hypothermia, has not been extensively studied in the context of CA/CPR. This study aimed to investigate the neuroprotective effects and mechanisms of olanzapine-induced hypothermia (OIH) following ROSC. Male Sprague-Dawley rats were subjected to the following conditions: (i) Sham: no asphyxial CA + saline, (ii) CA: asphyxial CA + saline, and (iii) OCA: asphyxial CA + olanzapine treatment after the return of spontaneous circulation (ROSC).
Result
CA/CPR resulted in high mortality, severe neurological impairments, and hippocampal neuron damage observed after 5 days in the asphyxia CA group. These pathological complications were ameliorated by olanzapine treatment. OIH also protected the pyramidal neurons in the CA1 region of the hippocampus. The expression of antioxidant factors SOD-1, SOD-2, and CAT were upregulated in the olanzapine-treated group compared to the CA group. Moreover, olanzapine treatment following asphyxial CA reduced the expression of the pro-inflammatory factor COX-2 and the nuclear transcription factor NF-κB, which was sustained for up to 5 days compared to the CA group. OIH provides protection against cerebral injury following ROSC by enhancing the expression of antioxidant and anti-inflammatory factors.
Conclusion
The results of our study demonstrate that Olanzapine, an atypical antipsychotic medication, induces a noteworthy reduction in body temperature in the asphyxial CA rat model. The effectiveness of hypothermia treatment was evident by its antioxidant and anti-inflammatory mechanisms. Therefore, we suggest olanzapine as a promising therapeutic agent for alleviating cerebral injury via hypothermia in patients with CA.
A Novel Adaptive Beamforming Scheme for Array Signal Data Processing
Authors: Shi Heping , Yan Guanghui , Hou Haijing , Jiang Xiaoheng 
Published: July 2023

Abstract
When the desired signal data exists in the array received data or the steering vector has a mismatch problem, the current traditional adaptive beamformers will suffer from the effect of the desired signal cancellation phenomenon, resulting in a sharp decline in performance. To address the occurrence of desired signal cancellation, an improved matrix projection-based efficient beamforming method is proposed. Firstly, based on spatial partitioning technology, a significant projection matrix for interference-plus-noise space (INS) is constructed. Secondly, using the constructed key projection matrix, the sample data covariance matrix is projected into the INS to achieve the goal of suppressing the desired signal data information. Finally, the weight data vector is calculated by Capon beamformer. The proposed algorithm does not require iterative search for the optimal solution, which has the advantage of a small amount of calculation. Simulation experiments have verified that the proposed method has significant advantages in suppressing the desired data signals. Especially when the desired data signal has a large power, the signal-to-interference-plus-noise ratio (SINR) of the proposed algorithm is better than that of the compared algorithms under the conditions of random directionality errors or local scattering errors between the desired signal and interference.
The Riesz Transform and Fractional Integral Operators in the Bessel Setting
Authors: Betancor Jorge J. , Duong Xuan Thinh , Lee Ming-Yi , Li Ji , Wick Brett D. 
Published: July 2023

Abstract

Fix λ > 0. Consider the Bessel operator λ := − d 2 dx 2 − 2λ x d dx on R + , where R + := (0, ∞) and dm λ := x 2λ dx with dx the Lebesgue measure. We provide a deeper study of the Bessel Riesz transform and fractional integral operator via the related Besov and Triebel–Lizorkin spaces associated with λ. Moreover, we investigate some possible characterization of the commutator of fractional integral operator, which was missing in the literature of the Bessel setting.
MSC Classification 2010: 42B30, 42B20, 42B35