bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solar panel shunt diodes and techniques for diagnosing them
Authors: Shaturaev Jakhongir , Muhabbat Hakimova , Farxod Turabekov , Jalil Hamidov , Kholmuratov Salim 
Published: May 2023

Abstract
The research article indicates the importance of carrying out measures for the diagnosis and maintenance of good-order standing shunt diodes as part of the solar panel. The study was carried out using the theoretical analytical analysis of information data on shunt diodes and their diagnostics. Defects considered solar panels due to defective shunt diodes. Used computer modeling in the PVSYST program, simulation of failures of shunt diodes on solar YL-250P-29b panels and their diagnostics by methods of short-circuit current analysis at partial shading and open circuit voltage parameter under normal conditions. It has been established that the methods of thermal imaging diagnostics (including using a drone) and visual inspection are not accurate tools. cops searching for faulty shunt diodes. For small solar power plants (as well as for diagnostic sticks of shunt diodes of solar panels from spare parts, tools, and fixtures on large solar power plants), short-circuit current analysis methods are applicable in partial shading and open circuit voltage parameter under normal conditions. For a complete diagnosis of shunt faults diodes at large solar power plants, the method of thermal imaging diagnostics using an external source.
Randomised Phase II Trial of Trifluridine/tipiracil (FTD/TPI) plus Ramucirumab (RAM) versus Trifluridine/tipiracil for Previously treated Patients with Advanced Gastric or Esophagogastric Junction Adenocarcinoma (RETRIEVE study, WJOG15822G)
Authors: Takahashi Naoki , Hara Hiroki , Nagashima Kengo , Hirata Kenro , Masuishi Toshiki , Matsumoto Toshihiko , Kawakami Hisato , Yamazaki Kentaro , Hironaka Shuichi , Boku Narikazu , Muro Kei 
Published: May 2023

Abstract
Background Trifluridine/tipiracil (FTD/TPI) prolongs survival in the third- or later-line treatment for advanced gastric cancer (GC), esophagogastric junction (EGJ) adenocarcinoma, and colorectal cancer. While single-arm phase II trials showed promising outcomes of FTD/TPI plus ramucirumab (RAM) as third- or later-line treatments for advanced GC or EGJ cancer, there have been no clinical trials to directly compare FTD/TPI plus RAM with FTD/TPI monotherapy. Therefore, we have started a randomised phase II trial to evaluate the efficacy and safety of FTD/TPI plus RAM compared with FTD/TPI monotherapy as third- or later-line treatments in patients with advanced GC and EGJ adenocarcinoma.Methods This RETREVE trial (WJOG15822G) is a prospective, open-label, randomised, multicentre phase II trial comparing FTD/TPI plus RAM versus FTD/TPI monotherapy in a third- or later-line setting. Eligibility criteria include age of > 20 years; performance status of 0 or 1; unresectable or recurrent gastric or EGJ adenocarcinoma; confirmed HER2 status; refractory or intolerant to fluoropyrimidine, taxane or irinotecan; refractory to RAM (not intolerant); and at least a measurable lesion per RECIST 1.1. FTD/TPI (35 mg/m2 twice daily, evening of day 1 to morning of day 6 and evening of day 8 to morning of day 13) was administered orally every 4 weeks, and RAM (8 mg/kg) was administered intravenously every 2 weeks. The primary endpoint is progression-free survival (PFS), and the secondary endpoints are overall survival, objective response rate, disease control rate, and safety. The expected hazard ratio of PFS is set as 0.7, assuming 4-month PFS rate of 27% in FTD/TPI monotherapy and 40% in FTD/TPI plus RAM. The number of subjects was 110, with a one-sided alpha error of 0.10 and power of 0.70.Discussion This study will clarify the additional effect of RAM continuation beyond disease progression on FTD/TPI in the third- or later-line setting for patients with advanced GC or EGJ cancer.Trial registration jRCTs041220120.
Enterprise's Strategies to Improve Financial Capital under Climate Change Scenario – Evidence of the Leading Country
Authors: Nguyen Minh-Hoang , Nguyen Quang Loc , La Viet-Phuong , Bhatti Muhammad Ishaq , Hoang Vuong-Quan 
Published: May 2023

Abstract

The threat of climate change poses manifold dangers for human health and well-being and the world’s ecosystems as well. One of the most widely accepted helpful measures to mitigate climate change-related risks is at the business or corporate level, aiming to reduce carbon dioxide emissions and innovate climate-friendly technology. However, doing so requires comprehensive factors, including legislation, company strategy, and finance. Using the Bayesian Mindsponge Framework (MBF) for analyzing 178 enterprises listed in the S&P 500 companies from 2016 to 2021, this paper examines how climate risk-mitigating efforts can affect their stock price and market value. The findings suggest that carbon dioxide emissions seriously affect stock price. In contrast, the income and mitigation strategies, including producing eco-friendly products, using renewable energy, and environmental expenditures investments, are positively associated with an increase in share value. However, such mitigation efforts are conditional on the income made by the company. Indicated here is that corporations must be able to transform financial capital from the stock market into bankable, climate-resilient projects. Based on these findings, we suggest that building an eco-surplus culture by stimulating climate change knowledge constitutes a promising approach to promoting a corporation’s mitigation efforts.
Effect of Functionalization of 2D Graphene Nanosheets on the Oxidation Stress the Cellular Response of BEAS-2B Cells
Authors: Umadevi Kovuri , Sundeep Dola , Varadharaj Eswaramoorthy K , Sastry Chebiyyam Chandrasekhara , Jhansi Ragala , Rajarikam Nagarjunachary 
Published: May 2023

Abstract
The present study is intended to determine the physiochemical properties of functionalized graphene leading to potential molecular or cellular injury. We investigated the role of functionalization of graphene oxide nanoflakes (GONPs) and the cellular responses in terms of viability and cytotoxicity of BEAS-2B cells. GONPs were synthesized by hummer’s method and obtained fine GONPs of 1.87 nm size. The crystalline dimensions, microstrain, and dislocation densities of the GONPs were analyzed by using XRD and a FESEM was used to determine the shape of the as-synthesized GONPs. The cytotoxicity and oxidative stress were evaluated using cultured BEAS-2B cells. GONPs were exposed to the cultured cells in an incremental dosage pattern. The interactions of GONPs with the cultured cells were studied using the analytical techniques flow cytometry, and FE-SEM imaging. It is found that GONPs interacted with the plasma membrane and whereas high concentration GONPs were detached from the cells and remained as foreign bodies which is observed through FESEM analysis From the obtained results we summarize the effect of functionalization of GNPs and their altered properties and their mechanism of interaction with non-phagocytic cell lines.
Effect of clinical and morphological characteristics on small and medium-sized(&lt;15mm) intracranial aneurysm rupture
Authors: Cui Xiaopeng , Wang Liang , Cheng Cheng , Zhao Yan , Song Yunfei , Wang Bangyue , Wu Zhuolin , Zhang Hengrui , Chen Lei , Yang Xinyu 
Published: May 2023

Abstract
Objective The aim of the present study was to retrospectively analyze and investigate the clinical and morphological data of 204 cases of ruptured intracranial aneurysms (RIAs) and unruptured intracranial aneurysms (UIAs). The risk factors predicting aneurysm rupture were explored from the perspective of the clinical and geometric morphology of small and medium-sized(< 15mm) intracranial aneurysm (IA) .Methods The geometric morphological parameters, including the condition of the aneurysm-carrying vessels, the shape of the daughter aneurysm, the distribution and size of the aneurysm location, the height of the aneurysm, the wide diameter of the aneurysm, the width of the aneurysm neck, AR, SR, BN, and HWR. A comprehensive and detailed analysis, ROC curve analysis and multifactor logistic regression analysis, were performed to explore the risk factors for small and medium-sized aneurysm rupture, including the incidence angle, aneurysm angle.Results Multifactor logistic regression analysis suggested that there were significant differences between Groups RIA and UIA regarding age(OR 2.458), atherosclerosis, bifurcation-type IA(OR 5.523), and SR(OR 4.695) (P < 0.05).The threshold values of Age and SR were 59.5 and 0.86.Conclusions Age(< 59.5), SR(> 0.86) and aneurysm at the bifurcation could be used as risk factors for small and medium-sized(< 15mm) IA rupture.In addition, the present findings indicated that atherosclerosis have a protective effect on aneurysm rupture.
A unified framework towards diagnostic test development and evaluation during outbreaks of emerging infections
Authors: Karch André , Chaturvedi Madhav , Köster Denise , Bossuyt Patrick , Gerke Oke , Hofner Benjamin , Jurke Annette , Kretzschmar Mirjam , Lütgehetmann Marc , Mikolajczyk Rafael , Reitsma Johannes , Schneiderhan-Marra Nicole , Siebert Uwe , Stekly Carina , Ehret Christoph , Rübsamen Nicole , Zapf Antonia 
Published: May 2023

Abstract

Background
Diagnostic tests play a crucial role during an epidemic or a pandemic, both for individual patient care, and as a tool in population-level non-pharmaceutical interventions. The development and evaluation of such tests during epidemics faces numerous challenges, including short timeframes, and changing disease prevalence, pathogen characteristics, and testing applications. In this position paper, we describe these challenges through an interdisciplinary lens and present potential solutions, based on experiences during the SARS-CoV-2 pandemic.
Methods
We conducted a workshop that brought together experts from various disciplines involved in diagnostic test development and evaluation, from molecular test development to public health decision-making. The challenges and potential solutions we discuss are derived from discussions had and conclusions drawn in the workshop.
Results
We identified a feedback loop between evaluation of test accuracy, integration of test accuracy estimates in modelling studies for public health decision-making, and population-level interventions that determine testing strategies, and can define how diagnostic tests might need re-evaluation. Incorporating this feedback loop into test evaluation can help diagnostic test development be optimised for both individual patient care and population level measures. Furthermore, adaptive and seamless designs for diagnostic studies provide a promising methodological solution to narrow timeframes and the need for continuous re-evaluation of diagnostic tests during epidemic or pandemic situations.
Conclusions
We present a framework for diagnostic test development and evaluation that acknowledges the feedback loop between diagnostic test studies and infectious disease modelling studies, and provides solutions to challenges faced in test development and evaluation during outbreaks of emerging infectious agents.
Impact assessment of self-medication on COVID-19 prevalence in Gauteng, South Africa, using an age-structured disease transmission modelling framework
Authors: Avusuglo Wisdom S. , Han Qing , Woldegerima Woldegebriel Assefa , Bragazzi Nicola , Asgary Ali , Ahmadi Ali , Orbinski James , Wu Jianhong , Mellado Bruce , Kong Jude Dzevela 
Published: May 2023

Abstract
Introduction: Self-medication, as a global phenomenon, remains a pressing issue that requires attention worldwide, in particular, the Global South. It has been a hindrance to infectious disease control as it, in most cases dampens interventions put forth by health authorities. It is imperative, therefore, that disease dynamics relating to self-medication are incorporated into mathematical models used to inform infectious disease-related public health interventions and policy. COVID-19-associated self-medication is well documented, and its implications for disease prevention and control are alarming. We investigated the impact of self-medication across different age groups on the transmission dynamics of the disease; the interplay of vaccination and self-medication on the spread of the disease; and the age group with the most tendency for self-medication. We used Gauteng Province, South Africa, as a case study.
Methods: We employed ordinary differential equations (ODEs), formulated within an age-structured compartmental disease modelling framework. Model parameters were estimated using a Markov Chain Monte Carlo (MCMC) estimation scheme. Uncertainty and sensitivity analysis were carried out on model parameters.
Results: The model implied estimates indicates that self-medication is predominant among Age group 15-64 (83.13%), followed by Age group 65+ (44.17%). Age group 0-14 records 33.82%. The mean value of the basic reproduction number, first epidemic peak, and first epidemic peak time are 3.19838, 821536, and 214.988, respectively.
Conclusion: Self-medicationplays a crucial role in combating COVID-19, and that regardless of the levelof effectiveness of instituted vaccination programs, it must be put in check. Appropriate campaign against COVID-19 related self-medication is justified. It is also worth noting that campaigns should target the active population (ages 14-64)
Image-based leaf disc assay for the rapid evaluation of genetic resistance to fire blight in apples
Authors: Tegtmeier Richard , Hickok David , Robins Kelly , Khan Awais 
Published: May 2023

Abstract
Fire blight, caused by Erwinia amylovora, is a destructive bacterial disease that severely hampers apple production. To conduct QTL (Quantitative Trait Locus) studies for breeding resistant apple cultivars, phenotyping of large genetic mapping populations of apples for fire blight resistance is essential. This, however, necessitates precise, quantitative data spanning multiple years, locations, and pathogen strains. It can be time-consuming and resource-intensive to keep QTL mapping populations for apples in the field and greenhouse. This creates a bottleneck for identifying novel QTL for fire blight resistance or developing resistant cultivars. To address this challenge, we present an image-based method for rapid and accurate phenotyping fire blight resistance using apple leaf discs. This leaf disc assay demonstrates significant (p < 0.05) percent disease area (PDA) differences in fire blight inoculations among eight apple genotypes with well-known resistance levels. Furthermore, the image-based leaf disc assay consistently shows a 40–70% difference in PDA between resistant and susceptible checks. We also report high within and across trial broad sense heritability values ranging from 0.86–0.97. We demonstrate the use of K-means clustering and best linear unbiased estimators (BLUEs) to combine multiple trials. This assay offers an efficient alternative to traditional fire blight screening methods, potentially improving our understanding of the host response and accelerating the development of resistant apple cultivars.
Design, Development and Validation of the Self-Perceived Health Scale (SPHS)
Authors: Tinajero-Chávez Lorena Ishel , Mora-Romo José Fernando , Bravo-Doddoli Andrea , Cruz-Narciso Beatríz Viridiana , Calleja Nazira , Toledano-Toledano Filiberto 
Published: May 2023

Abstract

Health is a multidimensional concept with notable psychological factors, such as self-perceived health (SPH). SPH is defined as the subjective assessment of individual health status, and it integrates information related to both physical and psychological aspects, such as lifestyle. This study describes the development of the Self-Perceived Health Scale (SPHS) and its validation in a Mexican sample (n = 600). Exploratory factor analysis (n = 303) and confirmatory factor analysis (n = 293) were carried out, and they supported the three-dimensionality of the SPH construct: physical health, psychological health and healthy lifestyle. A final 12-item scale was obtained, and the scale showed adequate validity and reliability, as well as measurement invariance between sexes, indicating its robustness.
Effective PV Source Integration using Dynamic shunt active power filter with Power Quality Augmentation in Three Phase System
Authors: Penagaluru Suresh , Sudheer Kasa 
Published: May 2023

Abstract

With the widespread use of power electronics in power system generates a lot of harmonics, voltage imbalance and reactive power demand, causing serious power quality problems. Harmonics and reactive power are the two important indicators for measuring grid power quality. Thus, reducing harmonics is an utmost task. With the increasingly severe energy crisis, development and utilization of new energy are inevitable. This paper designs a The DSAPF for improving power quality has great market application value. The ANFIS SMC based DSAPF control method is proposed for dealing with the abnormalities in supply in order to provide quality power to load. In control strategy, ANFIS SMC controller is proposed and compared their performance in terms of %THD and power factor at PCC. The performance of the proposed system is analyzed for distorted source and unbalanced source conditions. The proposed control strategies are verified by using MATLAB/SMULINK environment.
Flexibility and inflexibility in an Iranian sample: Psychometric properties of MPFI based on the Hexaflex model
Authors: Moosivand Mahboobeh , Koulemarzi Mohammad Javad Bagian , Shirazi Maryam Sayad 
Published: May 2023

Abstract
Objectives Acceptance and commitment therapy (ACT) emphasizes psychological flexibility as a factor of emotional, psychological, and social well-being, and inflexibility as a predictor of psychological disorders. The analysis of psychometric properties based on the multidimensional Hexaflex model is essential to evaluate the effectiveness of therapeutic interventions. Therefore, the purpose of this research was to analyze the psychometric properties of the Multidimensional Psychological Flexibility Inventory (MPFI) based on the Hexaflex model in a sample of Iranian university students.
Methods The present research was conducted using a correlational design. The present study investigated the psychometric properties of the flexibility/inflexibility scale (MPFI, Rolffs et al., 2016) in a sample of Iranian students. Results In the analysis of exploratory factors in a sample of 300 students, six factors were discovered for flexibility and six for inflexibility (56.3% for boys and 43.7% for girls). In the analysis of confirmatory factors in a sample of 388 people, the results confirmed 60 items in a total of six flexibility and inflexibility factors. This value can be used as a good approximation of flexibility, inflexibility, second-order model, and final model. Cronbach’s alpha values of acceptance, present moment awareness [or contact with the present moment], self as context, cognitive defusing, values, committed action, total flexibility, experiential avoidance, lack of present-moment awareness, self as content, fusion, lack of contact with values, inaction, and total inflexibility were reported as 0.818, 0.869, 0.862, 0.904, 0.935, 0.935, 0.942, 0.895, 0.839, 0.883, 0.904, 0.912, 0.941, and 0.941, respectively.
Conclusions The Farsi version of the MPFI for university students thus has excellent psychometric properties and can be utilized as a reliable ACT assessment tool. Keywords Acceptance and Commitment Therapy (ACT), Flexibility and Inflexibility, Hexaflex Model.
Characterization of oxidative stress-induced cgahp, a gene coding for alkyl hydroperoxide reductase, from industrial importance Corynebacterium glutamicum
Authors: Si meiru , Hu mengdie , Yang Mingfei , Peng Zhaoxin , Li Donghan , Zhao yuying 
Published: May 2023

Abstract
Alkyl hydroperoxide reductase (Ahp), comprised of four different subunits AhpC, AhpD, AhpE, and AhpF, is a thiol-based antioxidative enzyme with the ability to protect bacteria against oxidative stress. Functionally, AhpC and AhpE considered as peroxidases directly detoxify peroxides, while AhpD and AhpF as oxidoreductases restore oxidized peroxidases to their reduced form. Corynebacterium glutamicum ncgl0877 encodes a putative Ahp with a unique Cys-Pro-Phe-Cys (C-P-G-C) active-site motif, similar with those of the thiol-disulfide oxidoreductases such as thioredoxin (Trx), mycoredoxin-1 (Mrx1) and AhpD. However, its physiological and biochemical functions remain unknown in C. glutamicum. Here, we report that NCgl0877, designated CgAhp, is involved in the protection against organic peroxide (OP) stress. The cgahp-deleted strain is notably more sensitive to OP stress. The cgahp expression is controlled by a MarR-type transcriptional repressor OasR (organic peroxide- and antibiotic-sensing regulator). The physiological role of CgAhp in resistance to OP stresses is corroborated by its induced expression under stresses. Although CgAhp has a weak peroxidase activity toward OP, it mainly supports the OP-scavenging activity of the thiol-dependent peroxidase preferentially linked to the dihydrolipoamide dehydrogenase (Lpd)/dihydrolipoamide succinyltransferase (SucB)/NADH system. The C-P-G-C motif of CgAhp is essential to maintain the reductase activity. In conclusion, our study identifies CgAhp, behaving like AhpD, as a key disulfide oxidoreductase involved in the oxidative stress tolerance and the functional electron donor for peroxidase.
Predictive factors of survival in people with cystic fibrosis from a Spanish rare disease registry.
Authors: Rueda-Nieto Senay , Mondejar-Lopez Pedro , Mira-Escolano María-Pilar , Cutillas-Tolín Ana , Maceda-Roldán Luis-Alberto , Arense-Gonzalo Julián-Jesús , Palomar-Rodríguez Joaquín-A. 
Published: May 2023

Abstract

Background:Cystic fibrosis (CF) is the most common multisystem, chronic, and life-threatening rare disease in the Caucasian population. Progressive loss of lung function remains the leading cause of death. However, improvementsin prognosis and survival have caused CF to go from being a lethal disease in childhood to becoming an increasingly frequent pathology in adults. In Spain, the factors that influence survival have not been determined. The objective of the study is to analyse survival and determine the factors associated with it in people with CF from a region in southeastern Spain based on information from a rare disease registry.
Methods: A cross-sectional study was carried out in people with a confirmed diagnosis of CF up to December 31 2018, who were registered in the Rare Disease Information System of the Region of Murcia (SIERrm). The Kaplan‒Meier method and the log-rank test were used to estimate and compare survival curves. Predictors of survival were calculated using the Cox proportional hazards model.
Results:Of the 192 patients registered in SIERrm with a confirmed diagnosis of CF, 39 patients died with a median age of 22 years (IQR: 15.0 - 33.0), of which 77% were classified within high-risk genotypes. The median survival age was 26.0 years (95% CI: 22.0 - 30.0),and the 10-year survival from diagnosis was 87.6%. In addition, high-risk genotype [HR: 5.8 (95% CI: 1.97 - 16.94)], pancreatic insufficiency [HR: 5.4 (95% CI: 1.24 - 23.48)], chronic colonization by Pseudomonas aeruginosa [HR: 6.8 (95% CI: 1.21 - 38.54)], the development of CF-related liver disease [HR: 5.0 (95% CI: 1.61 - 15.61)] and bone anomalies [HR: 6.4 (95% CI: 1.91 - 21.61)] were associated with decreased survival (p<0.05).
Conclusions: In the Regionof Murcia, people with a high-risk genotype, pancreatic insufficiency, chronic colonization by Pseudomonas aeruginosa, and the development of CF-related bone and liver complications predict a higher risk of dying or being transplanted and therefore a decrease in survival. The use of population registries is useful for estimating survival and showing the factors associated with it, which is important for planning care needs and implementing personalized medicine that influences these factors.