bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of admission and outcome of patients admitted to the intensive care unit of Addis Ababa Burn Emergency and Trauma Hospital
Authors: Mamo Dirijit , Aklog Etsegenet , Gebremedhin Yemane 
Published: April 2023

AbstractData on patterns of intensive care unit (ICU) admission including age, and severity of illness is essential in developing better strategies for resource allocation to improve outcomes. A 2-year cross-sectional study of 268 patients using a systematic random sampling and structured questionnaire obtained from the database was conducted with the aim of examining patterns of admission among patients admitted to the ICU of Addis Ababa burn emergency and trauma (AaBET) hospital. Data were entered into Epi-Info version 3.5.3 and exported to SPSS version 24 for analysis. Bivariate and multivariate logistic regression were used for association. A P-value of 0.05 at a 95% confidence interval was declared clinically significant. Of the 268 charts reviewed, 193 (73.5%) of them were men with a mean age of 32.6 years. Trauma accounted for 163 (53.4%) of admissions. Burn admission category, Glasgow coma score of 3–8, and not receiving pre-referral treatment were found to be substantially correlated with mortality in both bivariate and multivariate analysis. Trauma constituted a sizeable cause of ICU admission. Road traffic accidents of traumatic brain injuries were the major causes of admission. Developing good pre-referral care equipped with manpower and ambulance services will improve the outcome.
One to one comparison of cell-free synthesized erythropoietin conjugates modified with linear polyglycerol and polyethylene glycol
Authors: Pouyan Paria , Zemella Anne , Schloßhauer Jeffrey L. , Walter Ruben M. , Haag Rainer , Kubick Stefan 
Published: April 2023

AbstractWith more than 20 Food and Drug Administration (FDA)-approved poly (ethylene glycol) (PEG) modified drugs on the market, PEG is the gold standard polymer in bioconjugation. The coupling improves stability, efficiency and can prolong blood circulation time of therapeutic proteins. Even though PEGylation is described as non-toxic and non-immunogenic, reports accumulate with data showing allergic reactions to PEG. Since PEG is not only applied in therapeutics, but can also be found in foods and cosmetics, anti-PEG-antibodies can occur even without a medical treatment. Hypersensitivity to PEG thereby can lead to a reduced drug efficiency, fast blood clearance and in rare cases anaphylactic reactions. Therefore, finding alternatives for PEG is crucial. In this study, we present linear polyglycerol (LPG) for bioconjugation as an alternative polymer to PEG. We report the conjugation of LPG and PEG by click-chemistry to the glycoprotein erythropoietin (EPO), synthesized in a eukaryotic cell-free protein synthesis system. Furthermore, the influence of the polymers on EPOs stability and activity on a growth hormone dependent cell-line was evaluated. The similar characteristics of both bioconjugates show that LPGylation can be a promising alternative to PEGylation.
Determination of diurnal rhythm of salivary corticosterone concentration in the domestic rabbit (Oryctolagus cuniculus f. domestica) using a non-invasive method
Authors: Kadlecova Gabriela , Volfova Martina , Chloupek Jan , Sebankova Monika , Hostovska Lucie , Voslarova Eva , Vecerek Vladimir 
Published: April 2023

AbstractThere are many advantages associated with the determination of the level of corticosterone in rabbits from saliva, since this is a non-invasive sample collection method that does not affect their welfare and provides a reliable reflection of the state of the animal at a given moment without the results being distorted as they may be, for example, when blood samples are taken. The aim of this study was to determine the diurnal rhythm in the concentration of corticosterone in the saliva of the domestic rabbit. Saliva samples were taken from six domestic rabbits five times during the daytime (at 6:00, 9:00, 12:00, 15:00 and 18:00) over the course of three consecutive days. The levels of corticosterone in the saliva of the individual rabbits displayed a diurnal rhythm during the course of the day, with a significant increase between 12:00 and 15:00 (p < 0.05). No statistically significant difference in the concentrations of corticosterone in the saliva of the individual rabbits was demonstrated. Although the basal value of corticosterone is not known in rabbits and is difficult to determine, the results of our study show the pattern of fluctuations in the concentration of corticosterone in the saliva of rabbits during the daytime.
Loss of neuron network coherence induced by virus-infected astrocytes: a model study
Authors: Stasenko Sergey V. , Hramov Alexander E. , Kazantsev Victor B. 
Published: April 2023

AbstractCoherent activations of brain neuron networks underlie many physiological functions associated with various behavioral states. These synchronous fluctuations in the electrical activity of the brain are also referred to as brain rhythms. At the cellular level, rhythmicity can be induced by various mechanisms of intrinsic oscillations in neurons or the network circulation of excitation between synaptically coupled neurons. One specific mechanism concerns the activity of brain astrocytes that accompany neurons and can coherently modulate synaptic contacts of neighboring neurons, synchronizing their activity. Recent studies have shown that coronavirus infection (Covid-19), which enters the central nervous system and infects astrocytes, can cause various metabolic disorders. Specifically, Covid-19 can depress the synthesis of astrocytic glutamate and gamma-aminobutyric acid. It is also known that in the post-Covid state, patients may suffer from symptoms of anxiety and impaired cognitive functions. We propose a mathematical model of a spiking neuron network accompanied by astrocytes capable of generating quasi-synchronous rhythmic bursting discharges. The model predicts that if the release of glutamate is depressed, normal burst rhythmicity will suffer dramatically. Interestingly, in some cases, the failure of network coherence may be intermittent, with intervals of normal rhythmicity, or the synchronization can disappear.
Comparative assessment of the biological activity of the green synthesized silver nanoparticles and aqueous leaf extract of Perilla frutescens (L.)
Authors: Tavan Mansoureh , Hanachi Parichehr , Mirjalili Mohammad Hossein , Dashtbani-Roozbehani Abolfazl 
Published: April 2023

AbstractGreen synthesized nanoparticles (GSNPs) display fascinating properties compared to physical and chemical synthesized ones. GSNPs are currently used in numerous applications such as food packaging, surface coating agents, environmental remediation, antimicrobial, and medicine. In the present study, the aqueous leaf extract of Perilla frutescens L. having suitable capping, reducing, and stabilizing compounds was used for green synthesis of silver nanoparticles (Pf-AgNPs). The bioreductant capacity of aqueous leaf extract of P. frutescens for Pf-AgNPs was determined by different confirmatory techniques including UV–Visible spectroscopy, XRD, FESEM, EDX, zeta potential, DLS, SERS, and FTIR analysis. The results exhibited that Pf-AgNPs had optimal size (< 61 nm), shape (spherical), and stability (− 18.1 mV). The antioxidant activity of Pf-AgNPs with both DPPH and FRAP assays was significantly higher compared to P. frutescens extract. Furthermore, Pf-AgNPs had high antimicrobial activity against Escherichia coli and Staphylococcus aureus (MIC = 0.78 mg/mL), and Candida albicans (MIC = 8 mg/mL) while the plant extract showed low antimicrobial activity against both bacterial strains and the fungus tested. Pf-AgNPs and P. frutescens extract also exhibited moderate toxicity on MCF-7 cancer cells with IC50 values of 346.2 and 467.4 µg/mL, respectively. The results provide insights into using the biosynthesized Pf-AgNPs as an eco-friendly material for a wide range of biomedical applications.
Differentially expressed microRNAs in peripheral blood cell are associated with downregulated expression of IgE in nonallergic childhood asthma
Authors: Lee Jyh-Hong , Wang Li-Chieh , Lin Yu-Tsan , Yang Yao-Hsu , Yu Hsin-Hui , Hu Ya-Chiao , Chiang Bor-Luen 
Published: April 2023

AbstractChildhood asthma is a heterogeneous disease characterized by chronic airway inflammation, leading to a broad range of clinical presentations. Nonallergic asthma is asthma without allergic sensitization. Both clinical manifestations and immunopathological mechanisms of nonallergic childhood asthma were rarely investigated. We aimed to compare the clinical features between nonallergic and allergic childhood asthma and apply microRNA to explore the underlying mechanism of nonallergic childhood asthma. We enrolled 405 asthmatic children (76 nonallergic, 52 allergic with total IgE < 150 IU/mL and 277 allergic with total IgE > 150 IU/mL). Clinical characteristics were compared between groups. Comprehensive miRNA sequencing (RNA-seq) was performed using peripheral blood from 11 nonallergic and 11 allergic patients with elevated IgE, respectively. Differentially expressed miRNA (DEmiRNA) were determined with DESeq2. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analysis was performed to determine functional pathways involved. Publicly available mRNA expression data was applied to investigate the predicted target mRNA networks via Ingenuity Pathway Analysis (IPA). The average age of nonallergic asthma was significantly younger (5.614 ± 2.743vs6.676 ± 3.118 years-old). Higher severity and worse control were more common in nonallergic asthma (two-way ANOVA,P < 0.0001). Long-term severity was higher, and intermittent attacks persisted in nonallergic patients. We identified 140 top DEmiRNAs based on false discovery rate (FDR)q-value < 0.001. Forty predicted target mRNA gene were associated with nonallergic asthma. The enriched pathway based on GO included Wnt signaling pathway. IgE expression was predicted to be downregulated by a network involving simultaneous interaction withIL-4, activation ofIL-10and inhibition ofFCER2. Nonallergic childhood asthma were distinct in their younger age, higher long-term severity and more persistent course. Differentially expressed miRNA signatures associate with downregulation of total IgE expression and predicted target mRNA genes related molecular networks contribute to canonical pathways of nonallergic childhood asthma. We demonstrated the negative role of miRNAs involved in regulating IgE expression indicating differences between asthma phenotypes. Identification of biomarkers of miRNAs could contribute to understand the molecular mechanism of endotypes in nonallergic childhood asthma, which can potentially allow delivery of precision medicine to pediatric asthma.
On the performance of non‐contiguous carrier aggregation in presence of subspectral errors
Authors: Zhang Jing , Yang Chao , Liu Zhenghong , Chen Zhe , Zheng Lin 
Published: April 2023

AbstractCarrier aggregation can not only increase communication bandwidth, but also improve spectrum efficiency and communication security. Considering the non‐contiguous multi‐subspectrum aggregation for the spectrum division transmission of arbitrary signal, the paper analyzes the performance impact on the demodulation of aggregated signal in the presence of subspectral amplitude and phase errors in receiver. The theoretical bit‐error rates (BER) of quaternary phase‐shift keying and M‐ary phase‐shift keying are derived to clarify the subspectrum synchronization accuracy requirements in non‐contiguous carrier aggregation. In addition, two adaptive equalizers requiring no pilot overhead are introduced to correct the distortion of aggregated signal caused by the subspectral errors. Both algorithms need no estimation of synchronization error but also have the tracking capability of phase error even with subspectral carrier error. Simulation results show the reliability of the theoretical BER performance and the excellent performance of the equalization algorithms.
An approximating pseudospectral method with state‐dependent coefficient optimization for nonlinear optimal control problem
Authors: Sun Jianfeng , Chen Xuesong 
Published: April 2023

AbstractThe approximating sequence Riccati equation method is an efficient approach for solving the nonlinear optimal control problems, but its neglect of nonlinear dynamics and necessary optimality condition makes the control law difficult to satisfy the optimality. In this paper, an approximating pseudospectral method with state‐dependent coefficient optimization algorithm is proposed to solve this defect. By introducing the approximating pseudospectral method, the original nonlinear problem is transformed into a sequence of linear subproblems, which preserves the nonlinearity of solution. Then a state‐dependent coefficient optimization algorithm based on the gradient projection technique is proposed, which ensures the optimality of the control law. A double‐layer optimization structure is designed to facilitate the coordination between the approximating method and the optimization algorithm. Theoretical analysis proves the convergence of the proposed method. Comparative case studies illustrate the effectiveness in reducing the performance index and ensuring the optimality of the control law.
Hydrogen‐powered smart grid resilience
Authors: Han Jiayi , Wang Jianxiao , He Zhihao , An Qi , Song Yiyang , Mujeeb Asad , Tan Chin‐Woo , Gao Feng 
Published: April 2023

AbstractWith an increasing frequency of natural disasters and security attacks, the safe and stable operation of smart grid has been challenged unprecedently. To reduce the economic loss and social impact caused by power outage accidents, it is urgent to develop and improve the smart grid technology, and strengthen the disaster resistance and recovery capability of smart grids when faced with extreme events. As an efficient and flexible secondary energy source, hydrogen is crucial in improving the resilience of smart grid and supporting energy security. To further promote the deep integration of hydrogen systems and smart grid and improve the energy system resilience, the resilience of smart grids supported by hydrogen is assessed here. First, a technical framework of hydrogen‐powered smart grid resilience is established, and the value of hydrogen‐powered smart grid resilience is analysed considering different time frames (before, during and after an extreme event) of smart grids facing extreme events. Then, hydrogen‐powered smart grid resilience is investigated from perspectives of pre‐prevention regulation, in‐process correction regulation, and post‐recovery regulation. Finally, future direction for hydrogen‐powered smart grid resilience is investigated and related policy suggestions are provided.
A Gaussian process cross-correlation approach to time-delay estimation in active galactic nuclei
Authors: Pozo Nuñez F. , Gianniotis N. , Polsterer K. L. 
Published: April 2023

Context. We present a probabilistic cross-correlation approach to estimate time delays in the context of reverberation mapping (RM) of active galactic nuclei (AGN).
Aims. We reformulate the traditional interpolated cross-correlation method as a statistically principled model that delivers a posterior distribution for the delay.
Methods. The method employs Gaussian processes as a model for observed AGN light curves. We describe the mathematical formalism and demonstrate the new approach using both simulated light curves and available RM observations.
Results. The proposed method delivers a posterior distribution for the delay that accounts for observational noise and the non-uniform sampling of the light curves. This feature allows us to fully quantify the uncertainty on the delay and propagate it to subsequent calculations of dependant physical quantities, such as black hole masses. The method delivers out-of-sample predictions, which enables us to subject it to model selection, and can calculate the joint posterior delay for more than two light curves.
Conclusions. Because of the numerous advantages of our reformulation and the simplicity of its application, we anticipate that our method will find favour not only in the specialised community of RM, but also in all fields where cross-correlation analysis is performed. We provide the algorithms and examples of their application as part of our Julia GPCC package.
Survey of Orion Disks with ALMA (SODA)
Authors: van Terwisga S. E. , Hacar A. 
Published: April 2023

Context. External far-ultraviolet (FUV) irradiation of protoplanetary disks has an important impact on their evolution and ability to form planets. However, nearby (< 300 pc) star-forming regions lack sufficiently massive young stars, while the Trapezium cluster and NGC 2024 have complicated star-formation histories and their O-type stars’ intense radiation fields (> 104 G0) destroy disks too quickly to study this process in detail.
Aims. We study disk mass loss driven by intermediate (10 − 1000 G0) FUV radiation fields in L1641 and L1647, where it is driven by more common A0- and B-type stars.
Methods. Using the large (N = 873) sample size offered by the Survey of Orion Disks with ALMA (SODA), we searched for trends in the median disk dust mass with FUV field strength across the region as a whole and in two separate regions containing a large number of irradiated disks.
Results. For radiation fields between 1 − 100 G0, the median disk mass in the most irradiated disks drops by a factor ∼2 over the lifetime of the region, while the 95th percentile of disk masses drops by a factor 4 over this range. This effect is present in multiple populations of stars, and localized in space, to within 2 pc of ionizing stars. We fitted an empirical irradiation – disk mass relation for the first time: Mdust,median = −1.3−0.13+0.14 log10(FFUV/G0) + 5.2−0.19+0.18.
Conclusions. This work demonstrates that even intermediate FUV radiation fields have a significant impact on the evolution of protoplanetary disks.
Yttrium-Catalyzed Regioselective Aminolysis of 2,3-Epoxy Esters and Amides
Authors: Wang Chuan , Yao Hongqing 
Published: April 2023

AbstractHerein, an yttrium-catalyzed regioselective ring-opening reaction of 2,3-epoxy esters and amides with amines as nucleophiles is presented. This method features high regiocontrol, an enantiospecific SN2 reaction pathway, a broad substrate scope, and mild reaction conditions, furnishing a wide range of α-hydroxy β-amino esters and amides in regioisomerically pure forms. Notably, the selective nucleophilic attack to the C-3 position is controlled by the directing effect of the carbonyl group of the substrates.
Overweight Impairs Postural Control of Female Night Workers
Authors: Narciso Fernanda Veruska , Dâmaso Ana R. , Barela Jose A. , Carvalho Adriana N. S. , Ruiz Francieli , de Queiroz Sandra Souza , Lemos Vanessa Silva , de-Andrade Andre Gustavo P. , Tufik Sergio , De-Mello Marco Túlio 
Published: April 2023

Abstract
Objectives To verify the relationships between sleep duration (Total Sleep Time – TST) and postural control of female night workers before and after shift. As well as, to verify if there is an influence of the body mass index (BMI) on the postural control of these female workers before and after shift.
Methods A total of 14 female night workers (mean age: 35.0 ± 7.7 years) were evaluated. An actigraph was placed on the wrist to evaluate the sleep-wake cycle. The body mass and height were measured, and BMI was calculated. Postural control was evaluated by means of a force platform, with eyes opened and eyes closed before and after the 12-hour workday.
Results There was an effect of the BMI on the velocity and the center of pressure path with eyes opened before (t = 2.55, p = 0.02) and after (t = 4.10, p < 0.01) night work. The BMI impaired the velocity and the center of pressure path with eyes closed before (t = 3.05, p = 0.01; t = 3.04, p = 0.01) and after (t = 2.95, p = 0.01; t = 2.94, p = 0.01) night work. Furthermore, high BMI is associated with female workers' postural sway (p < 0.05).
Conclusion Therefore, high BMI impairs the postural control of female night workers, indicating postural instability before and after night work.
A backpack-based myeloid cell therapy for multiple sclerosis
Authors: Kapate Neha , Dunne Michael , Kumbhojkar Ninad , Prakash Supriya , Wang Lily Li-Wen , Graveline Amanda , Park Kyung Soo , Chandran Suja Vineeth , Goyal Juhee , Clegg John R. , Mitragotri Samir 
Published: April 2023

Multiple sclerosis (MS) is an incurable autoimmune disease and is currently treated by systemic immunosuppressants with off-target side effects. Although aberrant myeloid function is often observed in MS plaques in the central nervous system (CNS), the role of myeloid cells in therapeutic intervention is currently overlooked. Here, we developed a myeloid cell-based strategy to reduce the disease burden in experimental autoimmune encephalomyelitis (EAE), a mouse model of progressive MS. We developed monocyte-adhered microparticles (“backpacks”) for activating myeloid cell phenotype to an anti-inflammatory state through localized interleukin-4 and dexamethasone signals. We demonstrate that backpack-laden monocytes infiltrated into the inflamed CNS and modulated both the local and systemic immune responses. Within the CNS, backpack-carrying monocytes regulated both the infiltrating and tissue-resident myeloid cell compartments in the spinal cord for functions related to antigen presentation and reactive species production. Treatment with backpack-monocytes also decreased the level of systemic pro-inflammatory cytokines. Additionally, backpack-laden monocytes induced modulatory effects on T
H
1 and T
H
17 populations in the spinal cord and blood, demonstrating cross talk between the myeloid and lymphoid arms of disease. Backpack-carrying monocytes conferred therapeutic benefit in EAE mice, as quantified by improved motor function. The use of backpack-laden monocytes offers an antigen-free, biomaterial-based approach to precisely tune cell phenotype in vivo, demonstrating the utility of myeloid cells as a therapeutic modality and target.
Controllable and enormous spin splitting in antiferromagnetic MnPSe3 through interfacial coupling with Janus MoSSe
Authors: Li Yingqiu , Zhang Zongnan , Wu Xuefeng , Wu Yaping , Li Xu , Zhang Chunmiao , Cao Yiyan , Wu Zhiming , Kang Junyong 
Published: April 2023

Abstract
The manipulation of spin and valley degree of freedom in two-dimensional materials is desirable for emerging applications in next-generation electronics. Here, we report a regulation of the spin splitting in monolayer antiferromagnetic MnPSe3 through stacking van der Waals (vdW) heterostructures with transition-metal dichalcogenides (TMDs). Different TMDs including Janus MoSSe, MoSe2, and MoS2 are engaged and the spin and valley dependences on stacking configurations, interfacial atoms, and interlayer spacings are comprehensively investigated based on first-principles calculations. The results show that spin degeneracy of MnPSe3 can be lifted through the interfacial interaction in the vdW heterostructures. Compared with the MnPSe3 interfacing with traditional TMDs (MoSe2 and MoS2), those with Janus TMDs (MoSSe or MoSeS) have larger spin splitting. A maximal spin splitting of 50.8 meV at valence band maximum is achieved in MoSSe/MnPSe3 heterostructure, and such splitting is further enhanced to 243.0 meV when the interlayer spacing is reduced to 2.9 Å. It is found that the different hybridizations between the d-orbitals of the two inequivalent Mn atoms in MnPSe3 and the above TMDs lead to the occurrence of net magnetic moments, and thus induce spin splitting. This work paves a novel way to modify the spin-valley properties of two-dimensional semiconductors.