bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zooarchaeology of the Iron Age–Urartu Ayanis citadel, Eastern Turkiye
Authors: Siddiq Abu B. , Işıklı Mehmet 
Published: March 2023

Abstract
Throughout over 30 years of expeditions at Ayanis citadel animal bones were of rare finds and mostly remained unreported. Here, this study presents the first zooarchaeological analyses of 10,553 animal bones and their fragments, predominantly unearthed from a royal midden of the citadel. The analyses were primarily based on the identification of species, age, sex, marks and modifications, and general pathological changes on mainly of 4,028 specimens observed with a diagnostic zone (DZ). Extensive measurements were taken to construct a reliable zooarchaeological dataset for the site and comparisons in future studies. Logarithmic Size Index (LSI) was calculated to understand the morphological status of Ayanis sheep, goats and cattle, as well as comparing with these domestic livestock in other Iron Ages sites. The results were further compared with faunal remains from contemporary Urartian sites including Bastam in northwestern Iran, and Karmir–Blur and Horom in western Armenia. Beyond epigraphic and textual sources, the study concludes with some direct archaeological evidence on both the roles of animals in food habit, rituals and animal (pig) taboo practiced by the Urartian elites at Ayanis citadel, as well as the bio-metric status of domestic livestock, and animal–human interactions within the broader socio-economic contexts of the Urartian world.
Retrospective study of an incisional hernia after laparoscopic colectomy
Authors: Kobayashi Toshinori , Miki Hisanori , Yamamoto Nobuyuki , Hori Soushi , Hatta Masahiko , Hashimoto Yuki , Mukaide Hiromi , Yamasaki Makoto , Inoue Kentaro , Sekimoto Mitsugu 
Published: March 2023

Abstract
Purpose: This study aimed to examine the incidence of incisional hernia (IH) in elective laparoscopic colorectal surgery (LC) using regulated computed tomography (CT) images intervals every 6 months.
Methods: We retrospectively examined the diagnosis of IH in patients who underwent LC for colorectal cancer at Kansai Medical University Hospital from January 2014 to August 2018. The diagnosis of IH was defined as loss of continuity of the fascia in the axial CT images.
Results: 470 patients were included in the analysis. IH was diagnosed in 47 cases at 1 year after LC. The IH size was 7.8 cm2 [1.3–55.6] . In total, 38 patients with IH underwent CT examination 6 months after LC, and 37 were already diagnosed with IH. The IH size was 4.1 cm2 [0–58.9]. The IH size increased in 17 cases between 6 months and 1 year postoperatively, and in 1 case, a new IH occurred. 47%(18/38) of them continued to grow until 1 year after LC. A multivariate analysis was performed on the risk of IH occurrence. SSI was most significantly associated with IH occurrence (OR:5.28 [2.14–13.05], p=0.0003).
Conclusion: In previous reports, IH was evaluated mainly by clinical symptoms, but in this study, CT was used to investigate the occurrence of IH. Therefore, we clarified that we were able to find IH while it is still small by CT taken regularly.
Mathematical statistical structure for quantum systems: There is no measurement problem
Authors: Mostafa Mohamed 
Published: March 2023

Abstract
In this work, we prove that the behavior of quantum systems during various measurement processes is fully understood through the statistical structure in quantum mechanics represented by the uncertainty principle. We also prove that any measurement process is never different from any interaction between quantum particles, and this is evidenced only by the existence of a minimum uncertainty in position characteristic of each measurement system imposed by the statistical-mathematical structure of quantum mechanics.
Evaluation of academic self-efficiency, community feeling, and academic achievement of students in the process of the Covid-19 pandemic by data mining techniques
Authors: KARABATAK Songül , YILDIRIM Özal , KARABATAK Murat 
Published: March 2023

Abstract
This study aimed to perform a sample educational data mining (EDM) application to draw attention to its EDM predictive power. The data set consisted of the opinions collected from university students. These data set variables were formed by distance education students' academic self-efficacy, sense of community, academic achievement averages, and some demographic variables. The descriptive model revealed latent patterns between variables in the study, and a predictive model was used to estimate variables. For this, the association rule method and classification algorithm were also used. At the end of the study, it was concluded that EDM could effectively find relationships between variables and predict variables.
CSF3 contributes to the invasive and metastatic phenotypes and associates with poor prognosis in patients with colorectal cancer via NF-κB signaling pathway
Authors: Xu Junfeng , Xie Hui , Li Ruoran , Ma Xianzong , Du Shuwen , Zhang Heng , Duan Changwei , Sheng Jianqiu , Yang Lang , Jin Peng 
Published: March 2023

Abstract
Background
Colony-stimulating factor 3 (CSF3) is a cytokine associated with inflammation, which mainly stimulates myeloid stem cell maturation, proliferation, and migration into circulation. However, the significance of CSF3 in colorectal cancer (CRC) remains unclear. Here, we aimed to examine the expression and impacts of CSF3 in CRC.
Methods
CSF3 expression was examined in CRC tissues and cells by IHC staining and western blot. RNA interference was used to silence CSF3 in CRC cells. The effects of CSF3 on biological behaviors such as proliferation and migration of CRC cells were examined in vitro and in vivo.
Results
CSF3 was highly expressed in CRC tissues and cells. CSF3 high level was correlated to patients’ age, with a feature of a higher pathological stage, more distant lymphatic metastasis and more severe lymph node invasion. Knocking down CSF3 led to decreased proliferation and migration, increased apoptosis, arrested cell cycle in vitro as well as impaired tumor growth in vivo. Mechanistically, CSF3 regulates CRC cell proliferation and apoptosis dependent on enhances p65 phosphorylation to facilitate NF-κB-mediated transcriptional activity.
Conclusion
Our study demonstrated that CSF3 interacts with the NF-κB signaling pathway to promote the progression of CRC. CSF3 might be a potential therapeutic target for CRC patients.
L5-S1 Foraminal Stenosis Degeneration after L4-5 Lumbar Spinal Stenosis for TLIF: Impact of Preoperative Spinal Muscle Quality
Authors: Chen Minghang , Zhang Peng , Lai Jiaxin , Li Sheng , Yu Weijie , Fan Shikang , Yan Xin , He Yaozhi , Teng Honglin 
Published: March 2023

Abstract
Study design: Retrospective cohort analysis.
Objective: Our study aimed to investigate the effect of preoperative lumbar muscle quality (including muscle cross-sectional area (CSA) and muscle fatty infiltration rate (FIR) on L5-S1 foraminal stenosis degeneration after L4-5 TLIF.
Summary of Background Data: Adjacent segment degeneration (ASD) was a major spinal fusion complication. The paraspinal muscle had been proven to be an essential factor influencing the happening of ASD. However, few studies had investigated the association between paraspinal muscle and adjacent segment foraminal stenosis degeneration (ASD-FS).
Methods: One hundred-thirteen patients diagnosed with lumbar spinal stenosis at L4-5 were involved. Paraspinal muscle measurements were obtained preoperatively and bilaterally from axial T2-weighted MR images. The parameters included the, psoas cross-sectional area (p-CSA), erector spinae cross-sectional area (es-CSA), multifidus cross-sectional area (m-CSA), psoas fatty infiltration rate (p-FIR), erector spinae fatty infiltration rate (es-FIR), and multifidus fatty infiltration rate(m-FIR). The foraminal parameters were obtained in the Computed Tomography system bilaterally, including posterior disc height (PDH), disc-to-facet distance (D-F), foraminal height (FH), and foraminal area (FA). The association between muscle quality and ASD-FS had also been studied.
Results: At the last follow-up, the DF, FH, and FA were significantly decreased compared to pre-operation, and the decrease in FA was significantly positively related to es-FIR and m-FIR.
Conclusion: FIR for lumbar muscles preoperative was a predictor for L5-S1 ASD-FS after TLIF surgery, and patients who had higher es-FIR and higher m-FIR were more inclined to develop L5-S1 ASD-FS.
Collegial Effects of Salt and Ultraviolet Radiation on Rice-Field Cyanobacterium Nostochopsis lobatus HKAR-21
Authors: Singh Ashish , Gupta Amit , Singh Prashant , Jaiswal Jyoti , Sinha Rajeshwar P. 
Published: March 2023

Abstract
Cyanobacteria are a primitive group of photosynthetic oxygen-evolving, Gram-negative prokaryotes. Similar to eukaryotic algae and higher plants, it engages in photosynthesis-dependent oxygen evolution with water as a proton source. Cyanobacteria can be used as a model system to study the mechanisms of signal transduction, photosynthesis, and membrane lipids under abiotic stress, which may also provide an applicable model for higher plants. Salt stress is an abiotic factor that significantly affects plant survival and development. Therefore, improving the salt tolerance of agriculturally important plants is critical. Similar to how rising ultraviolet radiation (UVR) has a negative impact on land and an aquatic ecosystem, climate change has significant interactions with it. Cyanobacteria endure diverse effects from UV radiation, especially UV-B (280–315 nm). These alterations result from the production of free radicals, and PSII is a key target of UVR in photosynthetic organisms. In this experiment, we looked at the variation in photopigments of the cyanobacterium and its photosynthetic performance. The effect of increasing salt concentration on total lipid, carbohydrate composition and PBPs has been assessed. During UV stress, antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX) were examined. After that, using 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA), ROS was detected in vivo. The induction of lipid peroxidation has been investigated to evaluate the impact of UV radiation on the cyanobacterial membrane in addition to enzymatic defensive systems.
A CT-based nomogram established for differentiating heterotopic pancreas from gastrointestinal stromal tumor: compared with a machine-learning model
Authors: Feng Na , Chen Hai-Yan , Wang Xiao-Jie , Lu Yuan-Fei , Zhou Jia-Ping , Zhou Qiao-Mei , Wang Xin-Bin , Yu Jie-Ni , Xu Jian-Xia , Yu Ri-Sheng 
Published: March 2023

Abstract
Objective: To identify CT features and establish a nomogram, compared with a machine learning-based model for distinguishing heterotopic pancreas (HP) from gastrointestinal stromal tumor (GIST).
Materials and methods: This retrospective study included 148 patients with pathologically confirmed HP (n = 48) and GIST (n = 100) in the stomach or small intestine that were less than 3 cm in size. Clinical information and CT characteristics were collected. A nomogram on account of lasso regression and multivariate logistic regression, and a RandomForest (RF) model based on significant variables in univariate analyses were established. Receiver operating characteristic (ROC) curve, mean area under the curve (AUC), calibration curve and decision curve analysis (DCA) were carried out to evaluate and compare the diagnostic ability of models.
Results: The nomogram identified five CT features as independent predictors of HP diagnosis: age, location, LD/SD ratio, duct-like structure, and HU lesion / HU pancreas A. Five features were included in RF model and ranked according to their relevance to the differential diagnosis: LD/SD ratio, HU lesion / HU pancreas A, location, peritumoral hypodensity line and age. The nomogram and RF model yielded AUC of 0.951 (95% CI: 0.842–0.993) and 0.894 (95% CI: 0.766–0.966), respectively. The DeLong test found no statistically significant difference in diagnostic performance (p > 0.05), but DCA revealed that the nomogram surpassed the RF model in clinical usefulness.
Conclusion: Two diagnostic prediction models based on a nomogram as well as RF method were reliable and easy-to-use for distinguishing between HP and GIST, which might also assist treatment planning.
Construction of Knowledge Tracing Model Based on Side Information
Authors: Xu Haoxin , Yin Jiaqi , Wang Chenglong , Gu Xiaoqing 
Published: March 2023

Abstract
Intelligent Tutoring Systems are becoming more and more important in online education. Knowledge Tracing is a crucial part of ITS and aims to track students' knowledge status according to their historical performance and predict their future performance. Recent research shows that Deep Knowledge Tracing (DKT) models exhibit better performance than traditional models. However, the input of the DKT models depends on the ID and the total number of Students, Knowledge components, and Questions (SKQ), so the DKT models can not quickly be transferred to other datasets. Moreover, the application of the trained models is strictly limited when they are put into use due to data privacy. To solve these problems, this study proposes 14 features as side information (information that does not contain ID) related to SKQ and constructs a Knowledge Tracing model based on Side Information (SIKT). The input of this model neither depends on specific ID and the total number of SKQ nor involves students' private information to apply to all datasets. The results in continual learning with three real-world datasets as independent tasks show that: 1) The SIKT model performs better than the baseline models on three datasets and uses the least number of parameters. The side information of students and questions has a significant impact on the effectiveness of knowledge tracing. 2) In continual learning, the SIKT model has better performance on tasks with wider data distribution and can share knowledge across different tasks. 3)The SIKT model does not have the problem of catastrophic forgetting and learns the knowledge of both the original task and the new task at the same time when learning new tasks. 4) The performance achieved by the SIKT model in continual learning is comparable to that achieved by pooling all tasks at once and the model can generalize better as the number of training tasks increases.
OR-1896 increases force of contraction in the isolated human atrium
Authors: Rayo-Abella Lina M. , Grundig Peter , Bernhardt Max N. , Hofmann Britt , Neumann Joachim , Gergs Ulrich 
Published: March 2023

Abstract
OR-1896 ((R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl) phenyl)-acetamide) is the main active metabolite of levosimendan. However, nobody has reported a positive inotropic effect of OR-1896 in isolated human cardiac preparations. The mechanism of action of OR-1896 remains controversial. Hence, we wanted to know whether OR-1896 exerts a positive inotropic effect in humans and what might be the underlying mechanism. Therefore, we measured the contractile effects of OR-1896 (0.01–10 µM cumulatively applied) in isolated electrically stimulated (1 Hz) human right atrial preparations (HAP), obtained during cardiac surgery. OR-1896 given alone exerted time- and concentration-dependent positive inotropic effects. 1 µM OR-1896 increased force by 72 ± 14.7% (p < 0.05, n = 6) and shortened the time of relaxation by 10.6 ± 3.6% (p < 0.05, n = 11) in HAP started at 0.1 µM, plateaued at 1 µM OR-1896 and was antagonized by 1 µM propranolol. The maximum positive inotropic effect of OR-1896 in human right atrial preparations was than that of 10 µM isoprenaline. EMD 57033 (10 µM), a calcium sensitizer, increased force of contraction further in the additional presence of 1 µM OR-1896 by 109 ± 19% (p < 0.05, n = 4). Cilostamide (10 µM), an inhibitor of phosphodiesterase III given before OR-1896 (1 µM) blocked the positive inotropic effect of OR-1896 in HAP. Our data suggest that OR-1896 is indeed a positive inotropic agent in the human heart. OR-1896 acts as a PDE III - inhibitor and OR-1896 is unlikely to act as a calcium sensitizer in the human heart.
Thin-film thermal system for nucleic acid amplification in digital microfluidics
Authors: HE Haipeng , Hu Chenxuan , Li Jiahao , Zhang Maolin , Liang Jiancong , Lin Baiquan , Xi Kerui , Wang Shurong , Ma Hanbin 
Published: March 2023

Abstract
Digital microfluidics system is a powerful platform to realise true lab-on-a-chip. While most biological applications have delicate temperature requirements, integration of a thermal system with microfluidics has become an obstacle for system minimization for applications in point-of-cares. In this paper, we developed a heating plate on glass based on thin-film technology, which is fully compatible with glass substrate-based digital microfluidic chip. The thin-film heating plate and the digital microfluidic chip were controlled with a customized driver circuit. We have carried out characterization experiments to verify the on-chip temperature uniformity and heating rate. We have demonstrated both Polymerase Chain Reaction and Recombinase Polymerase Amplification experiments with the proposed system. This work opens up a new way for portable glass-based digital microfluidic chips with a fully integrated thermal system.
Transcriptome Analysis and Single-Cell Sequencing Analysis Constructed the Metastasis-Related Signature in Melanoma and Identified CD74 as a Novel Biomarker
Authors: Huai Hongyu , Li Junpeng , Li Junliang , Lan Huan 
Published: March 2023

Abstract
A prevalent skin cancer with a dismal prognosis before it spreads, cutaneous melanoma is challenging to cure. We downloaded melanoma data from the TCGA database, and the patients there were split into two groups: one for training and one for validation. After that, tumor metastatic genes in melanoma were evaluated using univariate Cox regression, LASSO regression, and multivariate Cox regression. A predictive model linked to melanoma metastasis genes was then created. To categorize melanoma patients, the model might be employed. Melanoma patients in the training and validation cohorts could be divided into high-risk and low-risk groups; the high-risk group had a considerably worse prognosis (P <0.05). The theoretical groundwork for comprehending the function of metastatic genes in melanoma is established by our investigation. Several algorithms were used to evaluate the relationship between the immune cell infiltration level and the model gene CD74. In an immunotherapy cohort, CD74's capacity to forecast treatment outcome was evaluated. Prognosis was found to be improved by high CD74 expression. High CD74 expression was substantially linked to the activation of immune-related pathways, according to correlation pathway analysis. Patients who responded to immunotherapy and those with lower IC50 who received chemotherapeutic treatment tended to express CD74 at a higher level. In melanoma cell lines, RT-qPCR discovered a substantial downregulation of CD74 expression. Analysis of the single-cell transcriptome revealed that B cells express CD74 with excellent specificity. Analysis using "CellChat" demonstrated that CD74 participates in MIF and MHC-II-mediated pathways that control the immune microenvironment. In conclusion, CD74 will be helpful for immunotherapy and is a trustworthy biomarker for melanoma.
Increased CD44 Expression in Primary Meningioma: Its Clinical Significance and Association with Peritumoral Brain Edema
Authors: Sawaya Ryosuke , Yamaguchi Shigeru , Ishi Yukitomo , Okamoto Michinari , Echizenya Sumire , Motegi Hiroaki , Fujima Noriyuki , Fujimura Miki 
Published: March 2023

Abstract

Purpose: CD44 is a major cell surface receptor involved in cell adhesion and migration. The overexpression of CD44 is a poor prognostic factor in many neoplasms, including meningiomas. This study investigated the association between CD44 gene expression and clinical signatures of primary meningiomas.
Methods: CD44 gene expression was quantitatively evaluated by snap-freezing tumor tissues obtained from 106 patients with primary meningioma. The relationships between CD44 expression and clinical signatures of meningiomas, including histological malignancy, tumor volume, and peritumoral brain edema (PTBE), were analyzed. PTBE was assessed using the Steinhoff classification system (from SC-0 to SC-III).
Results: CD44 gene expression in World Health Organization grade 2 and 3 meningiomas was significantly higher than that in grade 1 meningiomas. In addition, CD44 expression increased with the severity of PTBE. Particularly, among the grade 1 meningiomas or small-sized tumors (maximum tumor diameter less than 43 mm), CD44 expression in tumors with severe PTBE (SC-II/III) was significantly higher than that in tumors without or mild PTBE (SC-0/I). Multivariate logistic regression analysis also revealed that overexpression of CD44was an independent significant factor of severe PTBE development in primary meningiomas.
Conclusion: In addition to tumor cell aggressiveness, CD44expression promotes the development of PTBE in meningioma. Since PTBE is a strong factor of tumor-related epilepsy or cognitive dysfunction in patients with meningioma, CD44 is thus a potential therapeutic target in meningioma with PTBE.
Heterotic Grouping and Combining Ability of Tropical Maize Inbred Lines under Northern Blight Infested Environments
Authors: OHUNAKIN Akinlolu O. 
Published: March 2023

Abstract
Knowledge of combining ability and heterotic grouping among maize (Zea mays L.) inbred lines is critical for any successful hybrid program and in northern leaf blight disease prone environments. Fourty-five (45) single cross hybrids and ten corresponding parental lines evaluation was carried out at five locations in Nigeria using a 5 × 11 alpha lattice design to estimate; i. their agronomic performance and stability of inbred lines and hybrids for grain yield in NLB infested locations, ii. their combining ability across locations, iii. effectiveness of the heterotic group’s specific and general combining ability method (HSGCA), which considers a single trait versus the Heterotic group general combining ability of multiple traits (‘HGCAMT’) for classifying the selected maize into heterotic classes. Significant GCA and SCA effects across environments revealed additive and dominant gene action in the inheritance of the traits. The greater proportion of GCA over SCA across environments indicates significance of additive gene action over dominance action among inbred lines with both methods. Both HSGCA and HGCAMT provided similar classification of the inbreds into two heterotic classes. ‘TZEEI 14 × TZEI 14’ and ‘TZEEI 14 × TZEI 134’ were identified as the best hybrids in this study, therefore, both hybrids should be broadly evaluated in multi-location trials and encouraged for adoption in environments with high NLB disease pressure.