bluuebunny/crossref_metadata_2025_split huggingface dataset:
MICRORNA ASSOCIATED WITH PERIPROSTHETIC OSTEOLOYSIS VIA JAK-STAT PATHWAY
Authors: Deng Y. , Zhang D. , Smith P. , Li R. 
Published: February 2023

Hip and knee arthroplasty (HKA) are two of the most successful orthopaedic procedures. However, one major complication necessitating revision surgery is osteolysis causing aseptic loosening of the prosthesis. JAK-STAT has been demonstrated to influence bone metabolism and can be regulated by microRNA (miRNA).Adult patients with osteolysis or aseptic loosening undergoing revision HKA were recruited. Age and gender matched patients undergoing primary hip or knee arthroplasty were our controls. Samples of bone, tissue and blood were collected and RNA isolation was performed. The best quality samples were used for RNA-sequencing. Data analysis was performed using RStudio and Galaxy to identify differentially expressed genes. Western blotting of IL6 was used to confirm protein expression.Five circulating miRNA were identified which had 10 differentially expressed genes in bone and 11 differentially expressed genes in tissue related to the JAK-STAT pathway. IL6 in bone and EpoR in bone were highly significant and IL6 in tissue, MPL in bone, SOCS3 in tissue, JAK3 in bone and SPRED1 in bone were borderline significant. Western blot results demonstrated up-expression of IL6 in bone tissue of revision patients.Periprosthetic osteolysis and aseptic loosening can be attributed to miRNA regulation of the JAK-STAT pathway in osteoblasts and osteoclasts, leading to increased bone resorption. These findings can be used for further experiments to determine utility in the clinical setting for identifying diagnostic markers or therapeutic targets.
CORRELATION ANALYSIS OF DIFFERENT PELVIC TILT DEFINITIONS: A PRELIMINARY STUDY
Authors: Chai Y. , Boudali A.M. , Farey J. , Walter W.L. 
Published: February 2023

Pelvic tilt (PT) is always described as the pelvic orientation along the transverse axis, yet four PT definitions were established based on different radiographic landmarks: anterior pelvic plane (PTa), the centres of femoral heads and sacral plate (PTm), pelvic outlet (PTh), and sacral slope (SS). These landmarks quantify a similar concept, yet understanding of their relationships is lacking. Some studies referred to the words “pelvic tilt” for horizontal comparisons, but their PT definitions might differ. There is a demand for understanding their correlations and differences for education and research purposes.This study recruited 105 sagittal pelvic radiographs (68 males and 37 females) from a single clinic awaiting their hip surgeries. Hip hardware and spine pathologies were examined for sub-group analysis. Two observers annotated four PTs in a gender-dependent manner and repeated it after six months. The linear regression model and intraclass correlation coefficient (ICC) were applied with a 95% significance interval.The SS showed significant gender differences and the lowest correlations to the other parameters in the male group (−0.3< r <0.2). The correlations of SS in scoliosis (n = 7) and hip implant (female, n = 18) groups were statistically different, yet the sample sizes were too small. PTm demonstrated very strong correlation to PTh (r > 0.9) under the linear model PTm = 0.951 × PTh - 68.284.The PTm and PTh are interchangeable under a simple linear regression model, which enables study comparisons between them. In the male group, SS is more of a personalised spinal landmark independent of the pelvic anatomy. Female patients with hip implant may have more static spinopelvic relationships following a certain pattern, yet a deeper study using a larger dataset is required. The understanding of different PTs improves anatomical education.
CALCULATING AND COMPARING THE MINIMAL CLINICALLY IMPORTANT DIFFERENCE FOR VETERANS RAND 12 UTILITY SCORE IN TOTAL KNEE ARTHROPLASTY
Authors: Zhou Y , Shadbolt C , Rele S , Spelman T , Dowsey M , Choong P , Schilling C 
Published: February 2023

Utility score is a preference-based measure of general health state – where 0 is equal to death, and 1 is equal to perfect health. To understand a patient's smallest perceptible change in utility score, the minimal clinically important difference (MCID) can be calculated. However, there are multiple methods to calculate MCID with no consensus about which method is most appropriate. The aim of this study is to calculate MCID values for the Veterans-RAND 12 (VR12) utility score using varying methods. Our hypothesis is that different methods will yield different MCID values.A tertiary institutional registry (SMART) was used as the study cohort. Patients who underwent unilateral TKA for osteoarthritis from January 2012 to January 2020 were included. Utility score was calculated from VR12 responses using the standardised Brazier's method. Distribution and anchor methods were used for the MCID calculation. For distribution methods, 0.5 standard deviations of the baseline and change scores were used. For anchor methods, the physical and emotional anchor questions in the VR12 survey were used to benchmark utility score outcomes. Anchor methods included mean difference in change score, mean difference in 12 month score, and receiver operating characteristics (ROC) analysis with the Youden index.Complete case analysis of 1735 out of 1809 eligible patients was performed. Significant variation in the MCID estimates for VR12 utility score were reported dependent on the calculation method used. The MCID estimate from 0.5 standard deviations of the change score was 0.083. The MCID estimate from the ROC analysis method using physical or emotional anchor question improvement was 0.115 (CI95 0.08-0.14; AUC 0.656).Different MCID calculation methods yielded different MCID values. Our results suggest that MCID is not an umbrella concept but rather many distinct concepts. A general consensus is required to standardise how MCID is defined, calculated, and applied in clinical practice.
Testing the Agreement Between a Traditional and UAV-Based Method for Quantifying Skips in Suboptimal Cotton Stands
Authors: Pena Martinez Enrique Eduardo , Ward Jason K. , Collins Guy , Nelson Natalie 
Published: February 2023

HighlightsAgreement in the mean difference between the traditional and the UAV-based method only occurred in poor stands.Effects of different sampling sizes between methods were evident in mediocre-to-good stand assessments.Abstract. When suboptimal cotton stands occur, growers face the decision to accept or reject the stand. The replanting decision is difficult because the tradeoffs associated with replanting expenditures and reduced yields are difficult to objectively assess. Traditional methods like visual assessments and manual counts of cotton stands are commonly used to support a replanting decision. Typically, manual counts of skip size and frequency will provide more accurate assessments of the stand than visual assessments, but they are cumbersome to conduct and may not provide clear evidence that a replant is needed. Still, manual counts are popular among cotton farmers and the scientific community. Skip counts generated with the help of unmanned aerial vehicles (UAV) are less popular among cotton growers but provide more coverage and a larger sampling size across a given field. Therefore, UAVs have the potential to overcome the limitations associated with traditional methods. The motivation behind this study is to inform readers if manual methods can still be used for accurate decision-making regarding the replanting decision. More specifically, we study the interchangeability, or agreement, between a manual and a UAV-based method using Bland-Altman plots. Each method quantified skips greater than or equal to 0.91 m at different sampling sizes. Treatment plots varied in their stand counts, skip size, and skip frequency. Agreement between both methods was only found in the lowest stand treatment, where skips of large sizes were predominant. Conversely, methods disagreed in the higher stand where skips greater than or equal to 0.91 m were scarce. Keywords: Agriculture, Altman, Bland, Drone, Gaps, Precision, Remote, Sensing, UAS.
POESIA INSUBMISSA IMERSA NO JARDIM FECHADO DE RAQUEL NAVEIRA
Authors: Leitão Mary , Dias Martins Elizabeth 
Published: February 2023

A obra poética de Raquel Naveira, desde a primeira publicação em 1989, apresenta traços de uma produção literária insubmissa. Misturando temas religiosos, históricos, literários e filosóficos, a autora sul-mato-grossense vem se destacando na literatura brasileira por apresentar um novo olhar acerca das narrativas tradicionalmente difundidas segundo uma perspectiva dominante. Apresentamos a leitura de poemas de três de suas obras: Guerra entre irmãos (1993), Caraguatá (1996) e Stella Maia (2001). Os textos eleitos foram publicados em Jardim Fechado (2015), fato destacado por se tratar de uma seleção feita pela própria poeta. No intuito de demonstrar o modo como a autora delineia uma perspectiva diferenciada dos momentos históricos que tematizam as obras, ao analisar os versos, realizamos um resgate dos fatos históricos, bem como identificamos os aspectos que ilustram uma poesia insubmissa, segundo a perspectiva de Roberto Pontes (1999), em Poesia insubmissa afrobrasilusa. É intrínseca a relação entre literatura e história, construindo um percurso que se encontra no âmbito dos estudos da literatura comparada. A partir das referidas leituras, observamos o constructo de uma identidade literária híbrida que deixa transparecer as diversas influências e os inúmeros resíduos com os quais se edificam, na poética de Raquel Naveira, os traços da literatura brasileira contemporânea. Trata-se de uma voz que nasce individual e cresce coletiva, comprovando a superação do ensimesmamento e o alcance de um modo de ser insubmisso.
X-Ray Holography: X-Ray Interactions and Their Effects
Authors: London Richard A. , Trebes James E. , Rosen Mordecai D. 
Published: February 2023

We summarize a theoretical study of the interactions of x rays with a biological sample during the creation of a hologram. The choice of an optimal wavelength for x-ray holography is discussed, based on a description of scattering by objects within an aqueous environment.
The problem of the motion resulting from the absorption of x rays during a short exposure is described. The possibility of using very short exposures in order to capture the image before motion can compromise the resolution is explored.
The impact of these calculation on the question of the feasibility of using an x-ray laser for holography of biological structures is discussed.
Soft X-Ray Amplification in a Magnetically Confined Recombining H-like and Li-like Plasma
Authors: Kim D. , Skinner C. H. , Wouters A. , Valeo E. , Voorhees D. , Suckewer S. 
Published: February 2023

A series of experiments with H-like carbon has been performed using a Nd/Glass laser ( maximum output energy is 100 J in 3 nsecs ) in a line focus configuration. The maximum gain observed was 8.1 cm−1 using 25 J laser energy. This work is an initial step toward the development of a soft x-ray amplifier for the presently operating C VI 182 Å soft x-ray laser in a CO2 laser produced plasma confined in a magnetic field.
The possibility of lasing action at 187.2 Å in Li-like Mg X, 154.7 Å in Li-like Al XI, and 129 Å in Li-like Si XII in a magnetically confined recombing plasma has been also investigated. A CO2 laser was focused onto a target assembly and the resulting plasma confined in a solenoidal magnet field up to 9 Tesla. Impurities such as iron or titanium were introduced to increase the cooling in the recombination phase to produce more favorable conditions for high gain. Gain-length products of 1 ~ 2 at 187.2 Å in Mg X, 3 ~ 4 at 154.7 Å in Al XI, and 1 ~ 2 at 129 Å in Si XII were observed. To better understand plasma dynamics, a one-dimensional hydro-atomic code has been developed to simulate the experiment. The comparison between experiments and computer simulation will be discussed.
Performance of screening tools for cervical neoplasia among women in low- and middle-income countries: A systematic review and meta-analysis
Authors: Smith Sabrina K. , Nwosu Oguchi , Edwards Alex , Zerihun Meseret , Chung Michael H. , Suvada Kara , Ali Mohammed K. 
Published: February 2023

Objective
To evaluate the performance of visual inspection with acetic acid (VIA) testing, visual inspection with Lugol’s iodine (VILI), primary HPV testing, and conventional Pap smear in detecting CIN2+ among non-pregnant women aged 30–65 in LMICs between 1990 and 2020.

Design
Systematic review and meta-analysis.

Setting and participants
Low- and middle-income countries, non-pregnant women aged 30–65.

Methods
CENTRAL (Cochrane Library), CINAHL, Embase, Global Health, PubMed, and Web of Science databases were systematically searched to identify studies evaluating the performance of cervical cancer screening methods in LMICs. A diagnostic test accuracy meta-analysis was conducted to evaluate the performance of 4 screening methods in detecting CIN2+ relative to biopsy or cytology reference standards. Pooled statistics for sensitivity, specificity, diagnostic odds ratios, and summary receiver operating characteristic curves were determined for each method. Subgroup analyses were performed to examine whether there was variation in performance based on different reference standards for defining CIN2+, specifically: colposcopy-directed biopsy, biopsy alone, colposcopy alone, or liquid-based cytology.

Results
Eighteen studies were identified through systematic review. Twelve studies were included in meta-analysis; 11 were cross-sectional and 1 was a randomized controlled clinical trial. The remaining six of the eighteen studies were inclided in a narrative syntehsis. Pooled estimates for sensitivity for VIA, VILI, primary HPV testing, and conventional Pap smear were 72.3%, 64.5%, 79.5%, and 60.2%, respectively; pooled estimates for specificity were 74.5%, 68.5%, 72.6%, and 97.4%, respectively; the diagnostic odds ratios were 7.31, 3.73, 10.42, 69.48, respectively; and the area under the summary receiver operating characteristic curves were 0.766, 0.647, 0.959, and 0.818, respectively. Performance of the screening method varied based on the reference standard used; pooled estimates using either colposcopy-directed biopsy or biopsy alone as the reference standard generally reported lower estimates; pooled estimates using either colposcopy alone or liquid-based cytology as references reported higher estimates.

Conclusions and implications
This meta-analysis found primary HPV testing to be the highest performing cervical cancer screening method in accurately identifying or excluding CIN2+. Further evaluation of performance at different CIN thresholds is warranted.
Clinical and economic burden of healthcare-associated infections: A prospective cohort study
Authors: Gidey Kidu , Gidey Meles Tekie , Hailu Berhane Yohannes , Gebreamlak Zigbey Brhane , Niriayo Yirga Legesse 
Published: February 2023

Introduction
Healthcare-associated infections (HAIs) have become a serious public health problem. Despite the fact that implementing evidence-based infection control strategies could prevent HAIs and save billions of dollars, Ethiopia lacks national surveillance studies on the rate, economic, and clinical burden of HAIs.

Objective
To assess the clinical and economic burden of HAIs in hospitalized patients at Ayder comprehensive specialized hospital.

Materials and methods
A prospective cohort study design was conducted in patients with and without HAIs. A review of medical records, interviews, and patient bills was used to extract necessary information. The patients in the two arms were matched based on age, sex, Charlson comorbidity index, and ward type. Measurable factors were compared between infected and uninfected patients using the paired ttest or McNemar’s test, as appropriate. Logistic regression was used to identify predictors of in-hospital mortality. Stata 14.1 was used to conduct all analyses.

Results
A total of 408 patients, 204 with HAIs and 204 without HAIs were included in the study. In-hospital mortality was higher in patients with HAI (14.7% vs 7.8%, P = 0.028). Patients with HAI stayed an average of 8.3 days longer than controls (18.85 vs 10.59, P<0.001). The average direct medical costs for patients with HAI were 3033 Ethiopian birrs (ETB) higher than controls (4826 vs 1793, P<0.001). The presence of HAIs (AOR: 2.22, 95% CI: 1.13–4.39) and admission to intensive care units (AOR: 3.39, 95% CI: 1.55–7.40) were significant predictors of in-hospital mortality.

Conclusion
HAIs have a significant impact on in-hospital mortality, the length of extra hospital stays, and extra costs for medical care. Patients admitted to intensive care units and those with HAIs were found to be significant predictors of in-hospital mortality. Interventions must be implemented to prevent HAIs, especially in patients admitted to intensive care units.
Development of a candidate reference measurement procedure by ID-LC-MS/MS for total tau protein measurement in cerebrospinal fluid (CSF)
Authors: Giangrande Chiara , Vaneeckhoutte Hélène , Boeuf Amandine , Lalere Béatrice , Hirtz Christophe , Lehmann Sylvain , Quaglia Milena , Delatour Vincent 
Published: February 2023

Abstract

Objectives
In clinical pratice, tau protein measurement generally relies on immunoassays (IAs), whose major drawback is the lack of results comparability due to differences in selectivity and/or calibration. This underlines the importance of establishing a traceability chain for total tau (t-tau) measurements. The objective of this work is to develop a higher order candidate reference measurement procedure (RMP) for the absolute quantification of t-tau in cerebrospinal fluid (CSF).

Methods
To calibrate the candidate RMP and establish metrological traceability to the SI units, a primary calibrator consisting in a highly purified recombinant protein was sourced. Its purity was evaluated by liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) and the protein mass fraction in solution was certified by amino acid analysis (AAA). An isotopically-labelled homologue was obtained to develop a candidate RMP by isotope dilution mass spectrometry (IDMS) for t-tau absolute quantification in CSF. Calibration blends and quality control (QC) materials were gravimetrically prepared and subjected to the same preparation workflow as CSF samples, followed by LC-HRMS analysis in Parallel Reaction Monitoring (PRM) mode.

Results
A primary calibrator has been developed and an IDMS candidate RMP has been validated for CSF t-tau. The candidate RMP was used to certify t-tau concentration in three pools of CSF (low, medium, high).

Conclusions
The candidate RMP will pave the road towards global standardization of CSF t-tau measurements. Together with commutable Certified Reference Materials (CRMs), it will allow evaluating and improving the accuracy and comparability of results provided by IAs.
Maximally nonlinear functions over finite fields
Authors: Ryabov Vladimir G. 
Published: February 2023

Abstract
An n-place function over a field

F

q

$ \mathbf {F}_q $

with q elements is called maximally nonlinear if it has the largest nonlinearity among all q-valued n-place functions. We show that, for even n=2, a function is maximally nonlinear if and only if its nonlinearity is

q

n
−
1

(
q
−
1
)
−

q

n
2

−
1

$ q^{n-1}(q - 1) - q^{\frac n2-1} $

; for n=1, the corresponding criterion for maximal nonlinearity is q − 2. For

q
>
2

$ q \gt 2 $

and even n=2, we describe the set of all maximally nonlinear quadratic functions and find its cardinality. In this case, all maximally nonlinear quadratic functions are quadratic bent functions and their number is smaller than the halved number of the bent functions.
Ökumenischer Lagebericht 2022: Anglikanismus
Authors: Haar Miriam 
Published: February 2023

Zusammenfassung
Im englischen Canterbury fand Ende Juli/Anfang August 2022 die 15. Lambeth-Konferenz der Anglikanischen Gemeinschaft statt. Der Artikel berichtet über diese Versammlung anglikanischer/episkopaler Bischöf:innen. Zudem werden der Umgang mit dem strittigen Thema Homosexualität sowie die Ökumene auf der Lambeth-Konferenz beleuchtet. Der Lagebericht endet mit einem Ausblick auf die künftigen Schwerpunkte der Anglikanischen Gemeinschaft.
The fate of probiotic species applied in intensive grow-out ponds in rearing water and intestinal tracts of white shrimp, Litopenaeus vannamei
Authors: Amin Muhamad , Pramujisunu Yoga , Lamid Mirni , Cahyoko Yudi , Odeyemi Olumide A. , Ali Muhamad , Nurhayati Awik P. D. 
Published: February 2023

Abstract

Introduction
Probiotics have been commonly practiced in commercial shrimp farms to increase pond production. However, these possibilities were based on the results of in vitro studies or laboratory in vivo trials. While studies on probiotic applications in commercial-scale farms are still rarely investigated, this study addresses the fate of probiotic species in ponds and the intestinal tract of white shrimps reared in an intensive aquaculture system.

Material and methods
Four commercial probiotic species (Lactobacillus plantarum, Lactobacillus fermentum, Bacillus subtilis, and Pseudomonas putida) were applied to the commercial shrimp ponds (@800 m2 area of high-density polyethene ponds) in the morning at a dose of 5 ppm once every 2 days in the first month, and once a week from second month onward. Then, the presence of the probiotic species was traced by collecting the rearing water and shrimp’s intestines on day 47 of culture to monitor their composition and abundance using high-throughput sequencing.

Results
None of the commercial probiotic species could be detected from both rearing water and shrimp intestinal tracts. These results suggest that the probiotic species had low viability and adaptability in the rearing pond as well as the shrimp intestines when applied on commercial-scale farms. These facts may explain the high variation in the yield among shrimp ponds in spite of having similar treatments.

Conclusion
Probiotic strains had low viability and adaptability in commercial farms. Thus, methods and strategies in probiotic application to commercial-scale shrimp farms should be evaluated and further developed to increase probiotic efficacy.
EDUCAÇÃO EM SAÚDE PARA ENFRENTAMENTO DOS IMPACTOS DA PANDEMIA NA SAÚDE MENTAL DA EQUIPE DE ENFERMAGEM
Authors: Marques de Oliveira Renata , Carolina de Oliveira Paiva Ana , Marcella Cordeiro Soares Geraldo Letícia , Carolina de Paula Oliveira Isabela , Alves de Andrade Elisângela , De Carvalho Mendes Juliane 
Published: February 2023

A pandemia da Covid-19 tem ocasionado sobrecarga de trabalho nos profissionais de saúde, principalmente na equipe de enfermagem, com consequências para a saúde mental desses profissionais. Dessa forma, a educação em saúde pode atuar como uma aliada para o enfrentamento das consequências da pandemia o que tange a saúde mental dos profissionais da saúde. Objetivou-se relatar a experiência de discentes de graduação em Enfermagem, de uma universidade federal, no planejamento e na implementação de ações de educação em saúde com profissionais de enfermagem que atuam em leitos de terapia intensiva no contexto da pandemia da Covid-19. Essa ação educativa, inicialmente, foi proposta pela disciplina Capacitação Pedagógica e, posteriormente, aliada ao projeto de extensão “Saúde Mental no Hospital das Clínicas da UFMG”. Essa foi uma ação educativa planejada e implementada, no período de janeiro a maio de 2021, por quatro discentes, uma docente da Escola de Enfermagem e uma enfermeira do setor alvo, por meio do desenvolvimento de dois informativos e de seis vídeos disponibilizados por meios virtuais, devido às condições de distanciamento social. Conclui-se que a implementação de ações educativas, no que se refere à saúde mental dos profissionais de enfermagem, se mostra necessária e pode contribuir para uma melhora na qualidade dos serviços prestados.