bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring the impact of the state of emergency on crime trends in Japan: a panel data analysis
Authors: Shimada Takahito , Suzuki Ai , Amemiya Mamoru 
Published: June 2023

Abstract
Purpose/Background
City-specific temporal analysis has been commonly used to investigate the impact of COVID-19-related behavioural regulation policies on crime. However, these previous studies fail to consider differences in the intensity of intervention among cities and the impact of these behavioural regulation policies on crime trends nationwide. This study performs panel data analyses to examine how the declaration of a state of emergency (SoE) affected ambient population and crime in Japan, taking advantage of the fact that the SoE was implemented at different times in different prefectures.

Methods
The current study uses two sets of panel data of 47 prefectures for 22 weeks from February to July 2020: (1) the data on ambient population in five types of locations provided by the Google Mobility Reports, and (2) official crime data of six types of crime: residential burglary, commercial burglary, theft of/from vehicle, bicycle theft, sexual assault, and violence and injury. Firstly, an ordinary least squares regression analysis was performed to examine the impact of the SoE on the ambient population. Then a negative binomial model with fixed effects was adopted to examine the effect of the ambient population on the crime trends.

Findings
The SoE declaration was found to increase the ambient population in ‘residential’, and decrease that in other settings including ‘workplaces’, ‘transit stations’, and ‘retail and recreation’ in targeted prefectures. Spill-over effects of the SoE were observed on the ambient population of non-SoE prefectures. The ambient population have impacted five out of the six types of crime examined, except for sexual assault. After controlling for the ambient population, we observed an increase in commercial burglary and theft of/from the vehicle in all prefectures during the SoE weeks, compared to the weeks when the SoE was not declared.

Conclusions
The declaration of the SoE during the COVID-19 pandemic changed the ambient population in the SoE-prefectures, resulting the changes in crime levels as well. In addition, the implementation of the SoE in specific prefectures was found to have a contextual impact on national-level crime trends. Furthermore, the implementation of the SoE caused changes in some crime types that could not be explained by the changes in the ambient population, suggesting that the implementation of the SoE affected offenders’ decision-making. It is also worth noting that the changes in ambient population and crime trends during the pandemic were observed in Japan where the behavioural regulation policy without law enforcement was introduced.
Safe and curative modified two-stage operation for T4 esophageal cancer after definitive chemoradiotherapy: a case report
Authors: Matsumoto Tasuku , Noma Kazuhiro , Maeda Naoaki , Kato Takuya , Moriwake Kazuya , Kawasaki Kento , Hashimoto Masashi , Tanabe Shunsuke , Shirakawa Yasuhiro , Fujiwara Toshiyoshi 
Published: June 2023

Abstract
Background
The prognosis of esophageal cancer (EC) with organ invasion is extremely poor. In these cases, definitive chemoradiotherapy (CRT) followed by salvage surgery can be planned; however, the issue of high morbidity and mortality rates persists. Herein, we report the long-term survival of a patient with EC and T4 invasion who underwent a modified two-stage operation after definitive CRT.

Case presentation
A 60-year-old male presented with type 2 upper thoracic EC with tracheal invasion. First, definitive CRT was performed, which resulted in tumor shrinkage and improvement in the tracheal invasion. However, an esophagotracheal fistula subsequently developed, and the patient was treated with fasting and antibiotics. Although the fistula recovered, severe esophageal stenoses made oral intake impossible. To improve quality of life and cure the EC, a modified two-stage operation was planned. In the first surgery, an esophageal bypass was performed using a gastric tube with cervical and abdominal lymph node dissections. After confirming improved nutritional status and absence of distant metastasis, the second surgery was performed with subtotal esophagectomy, mediastinal lymph node dissection, and tracheobronchial coverage of the fistula. The patient discharged without major complications after radical resection and has been recurrence-free for 5 years since the start of treatment.

Conclusion
A standard curative strategy could be difficult for EC with T4 invasion due to differences in the invaded organs, presence of complications, and patient condition. Therefore, patient-tailored treatment plans are needed, including a modified two-stage operation.
Connecting dryland fine-fuel assessments to wildfire exposure and natural resource values at risk
Authors: Wells Adam G. , Munson Seth M. , Villarreal Miguel L. , Sesnie Steven E. , Laushman Katherine M. 
Published: June 2023

Abstract
Background
Wildland fire in arid and semi-arid (dryland) regions can intensify when climatic, biophysical, and land-use factors increase fuel load and continuity. To inform wildland fire management under these conditions, we developed high-resolution (10-m) estimates of fine fuel across the Altar Valley in southern Arizona, USA, which spans dryland, grass-dominated ecosystems that are administered by multiple land managers and owners. We coupled field measurements at the end of the 2021 growing season with Sentinel-2 satellite imagery and vegetation indices acquired during and after the growing season to develop predictions of fine fuel across the entire valley. We then assessed how climate, soil, vegetation, and land-use factors influenced the amount and distribution of fine fuels. We connected fine fuels to fire management points, past ignition history, and socio-economic vulnerability to evaluate wildfire exposure and assessed how fuel related to habitat of the endangered masked bobwhite quail (Colinus virginianus ridgwayi).

Results
The high amount of fine fuel (400–3600 kg/ha; mean = 1392 kg/ha) predicted by our remote sensing model (R2 = 0.63) for 2021 compared to previous years in the valley was stimulated by near-record high growing season precipitation that was 177% of the 1990–2020 mean. Fine fuel increased across the valley if it was contained within the wildlife refuge boundary and had lower temperature and vapor pressure deficit, higher soil organic content, and abundant annual plants and an invasive perennial grass (R2 = 0.24). The index of potential exposure to wildfire showed a clustering of high exposure centered around roads and low-density housing development distant from fire management points and extending into the upper elevations flanking the valley. Within the Buenos Aires National Wildlife Refuge, fine fuel increased with habitat suitability for the masked bobwhite quail within and adjacent to core habitat areas, representing a natural resource value at risk, accompanied with higher overall mean fine fuel (1672 kg/ha) in relation to 2015 (1347 kg/ha) and 2020 (1363 kg/ha) means.

Conclusions
By connecting high-resolution estimates of fine fuel to climatic, biophysical and land-use factors, wildfire exposure, and a natural resource value at risk, we provide a pro-active and adaptive framework for fire risk management within highly variable and rapidly changing dryland landscapes.
Value of TI-RADS and elastography strain ratio in predicting malignant thyroid nodules: experience from a single center in Egypt
Authors: Okasha Hussein Hassan , Mansor Mona , Sheriba Nermine , Abdelfattah Yasmine , Abdelfatah Dalia , Orabi Hussein El , Elebrashy Ibrahim N. , Saif Aasem , Meligi Amr A. El , Elshazli Mostafa , Elhadidy Khaled Elsayed , Abushady Manal M. , Islam Elham E. , Yosef Tarek M. , Salama Ahmed Saad El Din , Ouf Tarek I. , Said Sami Mufeed , Eid Yara M. , Mohsen Ahmed Amr , Rizk Mary N. , Yousief Elham , Elrawi Hoda , Ahmed Thoraya M. , Roshdy Eman , Sedrak Heba Kamal , Din Hala Gamal El , Aboulsoud Samar , El-Sawy Shereen Sadik , El-Feki Mohamed A. , Alzamzamy Ahmed , Elenin Sameh Abou , Tag-Adeen Mohammed , Abdelhameed Huda , Awad Abeer 
Published: June 2023

Abstract
Introduction
Thyroid nodules are highly prevalent in the general population; therefore, it is crucial to discriminate benign from malignant nodules. A practical thyroid imaging reporting and data system (TI-RADS) for thyroid nodules and ultrasound elastography are valuable tools not only for characterization of nodules but also for the selection of tumors for fine-needle aspiration cytology (FNAC).

Objective
This study aimed to evaluate the diagnostic accuracy of US evaluation in the prediction of malignant thyroid nodules and evaluate the role of the elastography score, strain ratio (SR), and the TI-RADS scoring system as non-invasive tools in differentiation between malignant and benign thyroid nodules.

Material and methods
A total of 1269 patients were evaluated between February 2017 and April 2020 by a single expert thyroid ultrasound operator. The final diagnosis was achieved from cytological and/or histological evaluation and follow-up for at least 1 year.

Results
There were 1088 females and 181 males with a mean age of 44 ± 10 SD. The final diagnosis was 1197 benign nodules and 72 malignant nodules. Most malignant nodules were scored elastography score 4 (83.3%) and TI-RADS category 5 (86.11%). We found that nodules with antero-posterior to transverse (A-P/T) diameter > 1, have 21 times more risk to be malignant than those with A-P/T diameter < 1, patients with solitary thyroid nodules have 4.5 times to develop malignancy compared to those with multinodular goiter (MNG), nodules with absent halo have 4 times more risk of malignancy. Furthermore, microcalcifications in thyroid nodules increase the risk of malignancy 9 times compared to those without calcifications. SR was found to be an excellent discriminator to differentiate between benign and malignant nodules with P < 0.001. Also, we found that for every unit increase in SR, the risk of malignancy increased by 20%. We reported that the accuracy of ultrasonography in the detection of malignant thyroid nodules had a sensitivity of 89%, specificity of 98%, 70% PPV, and 99.3% NPV, with an overall accuracy of 97.2%.

Conclusion
The application of ultrasonographic non-invasive criteria for thyroid nodules in clinical practice might significantly reduce the number of unnecessary FNAC. Elastography, SR, and TI-RADS classification could be good predictors for malignant thyroid nodules.
Genomics of ERBB2-Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab
Authors: Lipsyc-Sharf Marla , Jain Esha , Collins Laura C. , Rosenberg Shoshana M. , Ruddy Kathryn J. , Tamimi Rulla M. , Schapira Lidia , Come Steven E. , Peppercorn Jeffrey M. , Borges Virginia F. , Warner Ellen , Snow Craig , Krop Ian E. , Kim Dewey , Weiss Jakob , Zanudo Jorge Gomez Tejeda , Partridge Ann H. , Wagle Nikhil , Waks Adrienne G. 
Published: June 2023

PURPOSE Erb-B2 receptor tyrosine kinase 2 ( ERBB2)–positive breast cancer (BC) is particularly common in young women. Genomic features of ERBB2-positive tumors before and after chemotherapy and trastuzumab (chemo + H) have not been described in young women and are important for guiding study of therapeutic resistance in this population. METHODS From a large prospective cohort of women age 40 years or younger with BC, we identified patients with ERBB2-positive BC and tumor tissue available before and after chemo + H. Whole-exome sequencing (WES) was performed on each tumor and on germline DNA from blood. Tumor-normal pairs were analyzed for mutations and copy number (CN) changes. RESULTS Twenty-two women had successful WES on samples from at least one time point; 12 of these had paired sequencing results from before and after chemo + H and 10 had successful sequencing from either time point. TP53 was the only significantly recurrently mutated gene in both pre- and post-treatment samples. MYC gene amplification was observed in four post-treatment tumors. Seven of 12 patients with paired samples showed acquired and/or clonally enriched alterations in cancer-related genes. One patient had an increased clonality putative activating mutation in ERBB2. Another patient acquired a clonal hotspot mutation in TP53. Other genomic changes acquired in post-treatment specimens included alterations in NOTCH2, STIL, PIK3CA, and GATA3. There was no significant change in median ERBB2 CN (20.3 v 22.6; Wilcoxon P = .79) between paired samples. CONCLUSION ERBB2-positive BCs in young women displayed substantial genomic evolution after treatment with chemo + H. Approximately half of patients with paired samples demonstrated acquired and/or clonally enriched genomic changes in cancer genes. ERBB2 CN changes were uncommon. We identified several genes warranting exploration as potential mechanisms of resistance to therapy in this population.
Serum 21-Deoxycortisol for Diagnosis of Nonclassic Congenital Adrenal Hyperplasia in Women With Androgen Excess
Authors: Ng Jennifer L , Lim Ee Mun , Zhang Rui , Beilby John P , Watts Gerald F , Brown Suzanne J , Stuckey Bronwyn G A 
Published: June 2023

Abstract

Context
Nonclassic congenital adrenal hyperplasia (NCCAH) requires exclusion before diagnosing polycystic ovary syndrome (PCOS). Increasing use of liquid chromatography and tandem mass spectrometry (LC-MS/MS) necessitates revision of immunoassay-based criteria for NCCAH. Measurement of 21-deoxycortisol (21DF) may simplify the diagnosis of heterozygosity (HTZ), the presence of 1 affected CYP21A2 allele, which currently relies on complex molecular studies.

Objective
We aimed to determine LC-MS/MS-specific criteria for NCCAH and HTZ and compare the diagnostic accuracy of 21DF and 17-hydroxyprogesterone (17OHP).

Methods
A cross-sectional study involving 99 hyperandrogenic females was performed. We identified females who had undergone both a synacthen stimulation test (SST) and CYP21A2 genotyping from 2010 to 2017, and prospectively recruited females referred for an SST to investigate hyperandrogenic symptoms from 2017 to 2021. Steroids were compared between genetically confirmed NCCAH, HTZ, and PCOS. Optimal 17OHP and 21DF thresholds for HTZ and NCCAH were determined by receiver operating characteristic analysis.

Results
Basal 17OHP, stimulated 17OHP, and 21DF were measured in 99, 85, and 42 participants, respectively. Optimal thresholds for NCCAH were 3.0 nmol/L and 20.7 nmol/L for basal and stimulated 17OHP, respectively. Basal and stimulated 21DF thresholds of 0.31 nmol/L and 13.3 nmol/L provided 100% sensitivity with specificities of 96.8% and 100% for NCCAH, respectively. Diagnostic thresholds for HTZ of 8.0 nmol/L, 1.0 nmol/L, and 13.6 for stimulated 17OHP, 21DF, and the ratio (21DF + 17OHP)/cortisol each provided 100% sensitivity with specificities of 80.4%, 90.5%, and 85.0%, respectively.

Conclusion
LC-MS/MS-specific 17OHP thresholds for NCCAH are lower than those based on immunoassay. LC-MS/MS-quantified 17OHP and 21DF accurately discriminate HTZ and NCCAH from PCOS.
Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer
Authors: Goliwas Kayla F. , Libring Sarah , Berestesky Emily , Gholizadeh Shayan , Schwager Samantha C. , Frost Andra R. , Gaborski Thomas R. , Zhang Jian , Reinhart-King Cynthia A. 
Published: June 2023

ABSTRACT
Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment, which can impact the mode and efficacy of tumor cell migration. CAFs are known to increase invasion of less-aggressive breast cancer cells through matrix remodeling and leader–follower dynamics. Here, we demonstrate that CAFs communicate with breast cancer cells through the formation of contact-dependent tunneling nanotubes (TNTs), which allow for the exchange of cargo between cell types. CAF mitochondria are an integral cargo component and are sufficient to increase the 3D migration of cancer cells. This cargo transfer results in an increase in mitochondrial ATP production in cancer cells, whereas it has a negligible impact on glycolytic ATP production. Manually increasing mitochondrial oxidative phosphorylation (OXPHOS) by providing extra substrates for OXPHOS fails to enhance cancer cell migration unless glycolysis is maintained at a constant level. Together, these data indicate that tumor–stromal cell crosstalk via TNTs and the associated metabolic symbiosis is a finely controlled mechanism by which tumor cells co-opt their microenvironment to promote cancer progression and may become a potential therapeutic target.
Src- and Abl-family kinases activate spleen tyrosine kinase to maximize phagocytosis and Leishmania infection
Authors: Ullah Imran , Barrie Umaru , Kernen Rebecca M. , Mamula Emily T. , Khuong Francis Tho Huu , Booshehri Laela M. , Rhodes Emma L. , Bradford James M. , Datta Arani , Wetzel Dawn M. 
Published: June 2023

ABSTRACT
Leishmania spp. are obligate intracellular parasites that must be internalized by phagocytic cells to evade immune responses and cause disease. The uptake of both Leishmania promastigotes (insect-stage parasites) and amastigotes (proliferative-stage parasites in humans and mice) by phagocytes is thought to be mainly host cell driven, not parasite driven. Our previous work indicates that host Src- and Abl-family kinases facilitate Leishmania entry into macrophages and pathogenesis in murine cutaneous leishmaniasis. Here, we demonstrate that host spleen tyrosine kinase (SYK) is required for efficient uptake of Leishmania promastigotes and amastigotes. A Src-family kinase–Abl-family kinase–SYK signaling cascade induces Leishmania amastigote internalization. Finally, lesion size and parasite burden during Leishmania infection is significantly decreased in mice lacking SYK in monocytes or by treatment with the SYK inhibitor entospletinib. In summary, SYK is required for maximal Leishmania uptake by macrophages and disease in mice. Our results suggest potential for treating leishmaniasis using host cell-directed agents.
Short-term surgical complications following fast-track medial unicompartmental knee arthroplasty
Authors: Bredgaard Jensen Christian , Gromov Kirill , Petersen Pelle B. , Jørgensen Christoffer C. , Kehlet Henrik , Troelsen Anders 
Published: June 2023

AimsMedial unicompartmental knee arthroplasty (mUKA) is an advised treatment for anteromedial knee osteoarthritis. While long-term survival after mUKA is well described, reported incidences of short-term surgical complications vary and the effect of surgical usage on complications is less established. We aimed to describe the overall occurrence and treatment of surgical complications within 90 days of mUKA, as well as occurrence in high-usage centres compared to low-usage centres.MethodsmUKAs performed in eight fast-track centres from February 2010 to June 2018 were included from the Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Database. All readmissions within 90 days of surgery underwent chart review and readmissions related to the surgical wound or the prosthesis were recorded. Centres were categorized as high-usage centres when using mUKA in ≥ 20% of annual knee arthroplasties. The occurrence of complications between high- and low-usage centres were compared using Fisher’s exact test.ResultsWe included 3,757 mUKAs: 2,377 mUKAs from high-usage centres and 1,380 mUKAs from low-usage centres. Surgical complications within 90 days occurred in 69 cases (1.8%), 45 (1.9%) in high-usage centres and 24 (1.7%) in low-usage centres (odds ratio (OR) 1.1 (95% confidence interval (CI) 0.65 to 1.8)). The most frequent complications were periprosthetic joint infections (PJIs) (n = 18; 0.48%), wound-related issues (n = 14; 0.37%), and periprosthetic fractures (n = 13; 0.35%). Bearing dislocations (n = 7; 0.19%) occurred primarily in procedures from high-usage centres. In high-usage centres, seven periprosthetic fractures (0.29%) occurred compared to six (0.43%) in low-usage centres (OR 0.68 (95% CI 0.20 to 2.0)). In high-usage centres, nine PJIs (0.38%) occurred compared to nine (0.65%) in low-usage centres (OR 0.58 (95% CI 0.22 to 1.6)).ConclusionSurgical complications are rare after fast-track mUKA surgery and with no difference in overall occurrence of surgical complications between high- and low-usage centres, although the risk of some specific surgical complications may favour high-usage centres.Cite this article: Bone Jt Open 2023;4(6):457–462.
Putting the Artificial Intelligence in Alternative Dispute Resolution
Authors: Abbott Ryan , Elliott Brinson S. 
Published: June 2023

This article argues that the evolving regulatory and governance environment for artificial intelligence (AI) will significantly impact alternative dispute resolution (ADR). Very recently, AI regulation has emerged as a pressing international policy issue, with jurisdictions engaging in a sort of regulatory arms race. In the same way that existing ADR regulations impact the use of AI in ADR, so too will new AI regulations impact ADR, among other reasons, because ADR is already utilizing AI and will increasingly utilize AI in the future. Appropriate AI regulations should thus benefit ADR, as the regulatory approaches in both fields share many of the same goals and values, such as promoting trustworthiness.
Keywords: artificial intelligence; online dispute resolution; alternative dispute resolution; regulation; governance; trustworthiness; transparency; fairness; diversity; explainability.
Immunoprotective Effect of Cocos nucifera Oil on Sheep Red Blood Cell-Induced Immunocompromised Rats
Authors: Idu MacDonald , Debby Igori , Gabriel Benjamin Ogunma 
Published: June 2023

The aim of this study is to investigate the immunoprotective effects of cold-pressed coconut oil in immunocompromised rat. Standard procedure was used to perform this research work with a modified method. The effect of immunomodulatory properties of coconut oil was evaluated after challenging the animals with 0.3 ml sheep red blood cells (SRBCs) intraperitoneally and further treated with graded doses (0.25, 0.5 and 1.0 ml/kg i.p) of the oil extract for 21 days. The hematological, CD4, CD8 biochemical and histopathological analysis were evaluated. Result obtained from this study showed a significant increase in hematological indexes (WBC: 11.70; LYM: 9.9 GRAN: 8.0 and HGB: 15.57) across the treated groups, but majorly at lowest dose (0.25 ml/kg). More so a significant increase in CD4 and CD8 Count specifically at 0.25 ml/kg (7.763 and 7.830). Anti-oxidant property of the oil extract at 0.25 ml/kg had a significant reduction in malondialdehyde with an increased in antioxidant enzymes (SOD, CAT and GPx) when compared with untreated control. The body weight of the animals in the treated groups showed a significant increase at 0.25 ml/kg of the oil extract when compared with the untreated control. Liver function test (ALT, AST and ALP) showed no significant increase in the treatment groups when compared with the controls. The histopathological result reveals a normal physiological structure of the heart, lungs, spleen, liver and kidney in lowest dose of the oil extract. In conclusion, this study validated the ethnomedicinal property of the plant.