bluuebunny/crossref_metadata_2025_split huggingface dataset:
The roles of different microRNAs in the regulation of cholesterol in viral hepatitis
Authors: Meng Xuan , Eslami Yeganeh , Derafsh Ehsan , Saihood Anwar , Emtiazi Nikoo , Yasamineh Saman , Gholizadeh Omid , Pecho Renzon Daniel Cosme 
Published: September 2023

AbstractCholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific cellular membrane structures. Cholesterol is involved in numerous cellular processes, including regulating virus entry into the host cell. Multiple viruses have been shown to rely on cholesterol for virus entry and/or morphogenesis. Research indicates that reprogramming of the host’s lipid metabolism is associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the progression to severe liver disease for viruses that cause chronic hepatitis. Moreover, knowing the precise mode of viral interaction with target cells sheds light on viral pathogenesis and aids in the development of vaccines and therapeutic targets. As a result, the area of cholesterol-lowering therapy is quickly evolving and has many novel antiviral targets and medications. It has been shown that microRNAs (miRNAs) either directly or indirectly target the viral genome, preventing viral replication. Moreover, miRNAs have recently been shown to be strong post-transcriptional regulators of the genes involved in lipid metabolism, particularly those involved in cholesterol homeostasis. As important regulators of lipid homeostasis in several viral infections, miRNAs have recently come to light. In addition, multiple studies demonstrated that during viral infection, miRNAs modulate several enzymes in the mevalonate/cholesterol pathway. As cholesterol metabolism is essential to the life cycle of viral hepatitis and other viruses, a sophisticated understanding of miRNA regulation may contribute to the development of a novel anti-HCV treatment. The mechanisms underlying the effectiveness of miRNAs as cholesterol regulators against viral hepatitis are explored in this review.

Graphical Abstract
Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons
Authors: Santos Altair Brito Dos , Thaneshwaran Siganya , Ali Lara Kamal , Leguizamón César Ramón Romero , Wang Yang , Kristensen Morten Pilgaard , Langkilde Annette E. , Kohlmeier Kristi A. 
Published: September 2023

Abstract
Background
Sleep disorders (SDs) are a symptom of the prodromal phase of neurodegenerative disorders that are mechanistically linked to the protein α-synuclein (α-syn) including Parkinson’s disease (PD). SDs during the prodromal phase could result from neurodegeneration induced in state-controlling neurons by accumulation of α-syn predominant early in the disease, and consistent with this, we reported the monomeric form of α-syn (monomeric α-syn; α-synM) caused cell death in the laterodorsal tegmental nucleus (LDT), which controls arousal as well as the sleep and wakefulness state. However, we only examined the male LDT, and since sex is considered a risk factor for the development of α-syn-related diseases including prodromal SDs, the possibility exists of sex-based differences in α-synM effects. Accordingly, we examined the hypothesis that α-synM exerts differential effects on membrane excitability, intracellular calcium, and cell viability in the LDT of females compared to males.

Methods
Patch clamp electrophysiology, bulk load calcium imaging, and cell death histochemistry were used in LDT brain slices to monitor responses to α-synM and effects of GABA receptor acting agents.

Results
Consistent with our hypothesis, we found differing effects of α-synM on female LDT neurons when compared to male. In females, α-synM induced a decrease in membrane excitability and heightened reductions in intracellular calcium, which were reliant on functional inhibitory acid transmission, as well as decreased the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) with a concurrent reduction in action potential firing rate. Cell viability studies showed higher α-synM-mediated neurodegeneration in males compared to females that depended on inhibitory amino acid transmission. Further, presence of GABA receptor agonists was associated with reduced cell death in males.

Conclusions
When taken together, we conclude that α-synM induces a sex-dependent effect on LDT neurons involving a GABA receptor-mediated mechanism that is neuroprotective. Understanding the potential sex differences in neurodegenerative processes, especially those occurring early in the disease, could enable implementation of sex-based strategies to identify prodromal PD cases, and promote efforts to illuminate new directions for tailored treatment and management of PD.
Joint trajectory and CoMP clustering optimization in UAV-assisted cellular systems: a coalition formation game approach
Authors: Abdelhakam Mostafa M. , Elmesalawy Mahmoud M. , Ibrahim Ibrahim I. , Sayed Samir G. 
Published: September 2023

AbstractIn this paper, the flexibility of unmanned aerial vehicles (UAVs), as well as the benefits of coordinated multi-point (CoMP) transmission, are utilized for mitigating the interference in cellular networks. Specifically, the joint problem of CoMP clusters and UAVs’ trajectories is addressed for downlink transmission in a UAV-assisted cellular system. The problem is presented as a non-convex optimization problem that aims to maximize the sum rate of the ground users by taking into account the clustering, UAV mobility and backhaul capacity constraints. Since the formulated problem is known to be NP-hard, we partition it into two sub-problems. Particularly, by using coalitional game theory, the CoMP clusters are obtained with a given UAVs’ trajectories. Then, UAVs’ trajectories are optimized with given CoMP clusters using successive convex approximation technique. Based on the block coordinate descent method, the two sub-problems are solved alternatively until convergence. Numerical results are conducted and demonstrated the effectiveness of the proposed algorithm.
Increasing the efficiency of study selection for systematic reviews using prioritization tools and a single-screening approach
Authors: Waffenschmidt Siw , Sieben Wiebke , Jakubeit Thomas , Knelangen Marco , Overesch Inga , Bühn Stefanie , Pieper Dawid , Skoetz Nicole , Hausner Elke 
Published: September 2023

Abstract
Background
Systematic literature screening is a key component in systematic reviews. However, this approach is resource intensive as generally two persons independently of each other (double screening) screen a vast number of search results. To develop approaches for increasing efficiency, we tested the use of text mining to prioritize search results as well as the involvement of only one person (single screening) in the study selection process.

Method
Our study is based on health technology assessments (HTAs) of drug and non-drug interventions. Using a sample size calculation, we consecutively included 11 searches resulting in 33 study selection processes. Of the three screeners for each search, two used screening tools with prioritization (Rayyan, EPPI Reviewer) and one a tool without prioritization. For each prioritization tool, we investigated the proportion of citations classified as relevant at three cut-offs or STOP criteria (after screening 25%, 50% and 75% of the citation set). For each STOP criterion, we measured sensitivity (number of correctly identified relevant studies divided by the total number of relevant studies in the study pool). In addition, we determined the number of relevant studies identified per single screening round and investigated whether missed studies were relevant to the HTA conclusion.

Results
Overall, EPPI Reviewer performed better than Rayyan and identified the vast majority (88%, Rayyan 66%) of relevant citations after screening half of the citation set. As long as additional information sources were screened, it was sufficient to apply a single-screening approach to identify all studies relevant to the HTA conclusion. Although many relevant publications (n = 63) and studies (n = 29) were incorrectly excluded, ultimately only 5 studies could not be identified at all in 2 of the 11 searches (1x 1 study, 1x 4 studies). However, their omission did not change the overall conclusion in any HTA.

Conclusions
EPPI Reviewer helped to identify relevant citations earlier in the screening process than Rayyan. Single screening would have been sufficient to identify all studies relevant to the HTA conclusion. However, this requires screening of further information sources. It also needs to be considered that the credibility of an HTA may be questioned if studies are missing, even if they are not relevant to the HTA conclusion.
A systematic review of the role of community pharmacists in the prevention and control of cardiovascular diseases: the perceptions of patients
Authors: Motlohi Nthabiseng Florina , Wiafe Ebenezer , Mensah Kofi Boamah , Padayachee Neelaveni , Petrus Ruwayda , Bangalee Varsha 
Published: September 2023

Abstract
Background
Cardiovascular diseases are a leading cause of mortality globally. The modifiable risk factors can be measured and identified early at primary healthcare facilities. Community pharmacists present an opportunity for improved management of cardiovascular diseases and health outcomes. The systematic review aims to identify the roles of community pharmacists in preventing and controlling cardiovascular diseases and patients’ perceptions towards such functions.

Methods
A systematic review of the literature was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The team searched MEDLINE, CINAHL via EBSCOhost, and Web of Science from January 2001 to December 2021 with a focus on studies reporting the role of community pharmacists in preventing and controlling cardiovascular diseases, and patients’ perceptions of such roles. Search terms included were ‘‘interventions,’’ ‘‘community pharmacists,’’ ‘‘patients,’’ ‘‘cardiovascular diseases,’’ ‘‘risk factors,’’ and “perceptions”. The quality of studies was appraised using the Joanne Briggs Institute checklist.

Results
A total of 45 studies met the inclusion criteria: 35 (78%) and 10 (22%) reported community pharmacists’ preventive and control roles, respectively. Generally, drug therapy monitoring, medicine and lifestyle counselling, and health education were most common roles, with pharmacist-initiated prescribing and social support least common. A total of 11 (24%) studies reported patients’ perceptions of community pharmacists’ contribution in preventing (73%, n = 8) and controlling (27%, n = 3) cardiovascular diseases. Patients were satisfied with community pharmacists’ services in 10 of 11 studies.

Conclusions
The findings highlight community pharmacists’ capability of providing primary healthcare services in preventing and controlling cardiovascular diseases and provide evidence for their inclusion in primary healthcare frameworks. Future research should assess the effectiveness of these roles and provide a comprehensive evaluation of clinical, humanistic, and economic outcomes.

Systematic review registration
Open Science Framework (OSF) registration https://doi.org/10.17605/OSF.IO/WGFXT.
Acceptability, feasibility and short-term outcomes of temperament based therapy with support (TBT-S): a novel 5-day treatment for eating disorders
Authors: Stedal Kristin , Funderud Ingrid , Wierenga Christina E. , Knatz-Peck Stephanie , Hill Laura 
Published: September 2023

Abstract
Background
Temperament Based Therapy with Support (TBT-S) aims to target the mechanisms underlying the aetiology and maintenance of eating disorders, and was developed as an adjunct to treatment as usual. There is limited research investigating acceptability, feasibility and possible benefits of TBT-S. Therefore, the primary aim of the current study was to assess treatment feasibility and acceptability at a tertiary specialized eating disorders service in Norway, with a secondary aim to explore possible benefits in clinical outcome.

Methods
Forty-one patients (mean age 25.3, range 18–43) and 58 supports were assessed pre- and post TBT-S. The majority of the patients were diagnosed with either anorexia nervosa or atypical anorexia nervosa. Participants completed an 18-item Patient and Support Satisfaction Questionnaire, in addition to a questionnaire assessing the usefulness of the different intervention components and strategies utilised in TBT-S, as well as a 4-item treatment satisfaction questionnaire. Measures of treatment efficacy were completed at both time-points, whereas treatment acceptability was only assessed post-treatment.

Results
Findings reveal that TBT-S is a feasible treatment with high client satisfaction. Preliminary outcome data were also encouraging, and in line with previous studies. There were no voluntary drop-outs. All participants, both patients and supports, reported that TBT-S helped them deal more effectively with their challenges. After completing treatment, there was a significant decrease in patients’ self-reported eating disorder psychopathology, psychosocial impairment and state anxiety, while trait anxiety remained unchanged. Patients also reported significantly improved social relationships, whereas supports reported a significant increase in (own) psychological health. There were no differences in family functioning.

Conclusions
TBT-S is a promising new treatment for eating disorders with high acceptability scores and low treatment attrition. Future studies should aim to explore methods which can most appropriately measure the effect of TBT-S and the usefulness of the different components of this treatment. Randomised controlled trials are needed to assess treatment efficacy of TBT-S.
Effects of pole dance on mental wellbeing and the sexual self-concept—a pilot randomized-controlled trial
Authors: Pfeiffer Jalda Lena , Sowitzki Setia Kati , Schäfer Thomas , Euteneuer Frank 
Published: September 2023

Abstract
Background
Prior studies on beneficial effects of dance have primarily focused on traditional and expressionistic dance forms, neglecting newer dance styles like pole dance, which employ distinct techniques. The present pilot randomized controlled trial examined psychological and psychosexual effects of pole dancing.

Methods
Fifty women were randomized to an eight-weeks pole dancing program or waitlist. The primary outcome was global mental wellbeing. Secondary outcomes included several dimensions of the sexual self-concept, as well as body appreciation and global self-esteem.

Results
Compared to waitlist, the pole dance group showed an increase in mental wellbeing and improvements in sexual self-efficacy, sexual anxiety, sexual self-esteem, and body appreciation.

Conclusions
Pole dancing may have broad psychological effects on both overall mental wellbeing and important domains of the sexual self-concept.
Rhythm of relationships in a social fish over the course of a full year in the wild
Authors: Monk Christopher T. , Aslak Ulf , Brockmann Dirk , Arlinghaus Robert 
Published: September 2023

Abstract
Background
Animals are expected to adjust their social behaviour to cope with challenges in their environment. Therefore, for fish populations in temperate regions with seasonal and daily environmental oscillations, characteristic rhythms of social relationships should be pronounced. To date, most research concerning fish social networks and biorhythms has occurred in artificial laboratory environments or over confined temporal scales of days to weeks. Little is known about the social networks of wild, freely roaming fish, including how seasonal and diurnal rhythms modulate social networks over the course of a full year. The advent of high-resolution acoustic telemetry enables us to quantify detailed social interactions in the wild over time-scales sufficient to examine seasonal rhythms at whole-ecosystems scales. Our objective was to explore the rhythms of social interactions in a social fish population at various time-scales over one full year in the wild by examining high-resolution snapshots of a dynamic social network.

Methods
To that end, we tracked the behaviour of 36 adult common carp, Cyprinus carpio, in a 25 ha lake and constructed temporal social networks among individuals across various time-scales, where social interactions were defined by proximity. We compared the network structure to a temporally shuffled null model to examine the importance of social attraction, and checked for persistent characteristic groups over time.

Results
The clustering within the carp social network tended to be more pronounced during daytime than nighttime throughout the year. Social attraction, particularly during daytime, was a key driver for interactions. Shoaling behavior substantially increased during daytime in the wintertime, whereas in summer carp interacted less frequently, but the interaction duration increased. Therefore, smaller, characteristic groups were more common in the summer months and during nighttime, where the social memory of carp lasted up to two weeks.

Conclusions
We conclude that social relationships of carp change diurnally and seasonally. These patterns were likely driven by predator avoidance, seasonal shifts in lake temperature, visibility, forage availability and the presence of anoxic zones. The techniques we employed can be applied generally to high-resolution biotelemetry data to reveal social structures across other fish species at ecologically realistic scales.
Temperature-dependent effects on some biological aspects of two ectoparasitoids of Phyllocnistis citrella (Lepidoptera: Gracillariidae)
Authors: Ullah Muhammad Irfan , Arshad Muhammad , Ali Sajjad , Aatif Hafiz Muhammad , Zahid Syed Muhammad Ali , Altaf Nimra 
Published: September 2023

Abstract
Background
Temperature alters host suitability for the development of parasitoids through direct (thermal effect) and indirect (parental effect) pathways. The effects of three temperature regimes on the development and survival of two parasitoid species, Citrostichusphyllocnistoides (Narayanan) and Cirrospilusingenuus Gahan (Eulophidae: Hymenoptera) of the citrus leafminer, Phyllocnistiscitrella Stainton (Lepidoptera: Gracillariidae) was evaluated. The experiment was conducted at 20, 25, and 30°C temperatures with 65 ± 2% relative humidity (R.H.) and 16h: 8h (L: D) photoperiod.

Results
In C.phyllocnistoides, the pre-ovipositional period was longer at 20°C, while non- significant difference was observed in the pre-ovipositional period of C.ingenuus under the effect of different temperatures (P > 0.05). The ovipositional period of C.phyllocnistoides and C.ingenuus was higher at 20°C and gradually decreased by increasing the temperature. Non- significant (P > 0.05) difference was found in post-ovipositional period of both parasitoid species. Both species exhibited the maximum fecundity at 25°C, while, the minimum fecundity was recorded at 30°C. However, the adult longevity of both parasitoid species was highest at 20°C and gradually decreased by increasing the temperature. In both parasitoids, the parasitism rate was highest at 25°C.

Conclusion
This study highlighted the importance of thermal effects on some parasitoid species of insect pests to predict the future of trophic dynamics in global warming situations.
Prevalence and forms of sexual dysfunctions in Egyptian men with epilepsy in Helwan
Authors: Abou Elmaaty Ali Ahmed , El Sherifi Saad Shawki , Elserafy Tamer Sabry , Ismael Ahmed Fawzi 
Published: September 2023

Abstract
Background
Although there is a striking impact of epilepsy on sexual functions, this issue is avoided by the patients, because they consider it as a taboo that brings much shame to the complainer and also largely ignored by physicians and neurologists who involved in epileptic patient management. Our aim was to investigate the prevalence and forms of sexual dysfunction (SD) in Egyptian men with epilepsy and relating this dysfunction to the type of epilepsy and the existing sex hormone disturbance.

Methods
We recruited seventy male epileptic patients on anti-seizure medications and seventy healthy males aged-matched control subjects. We assessed their sexual functions using IIEF-15.

Results
The prevalence of SD in epileptic patients in our study was as follows: erectile function (64.3%), sexual desire (45.7%), intercourse satisfaction (37.2%) and orgasmic function (15.7%). We found statistically significant lower IIEF scores in uncontrolled versus controlled epileptic patients, in spite that total and free testosterone were not statistically significantly different between the two groups. Although a lower IIEF score in focal versus generalized epilepsy was noticed, but only orgasmic function achieved statistical significance (P = 0.049). Our results exhibited no statistically significant difference as regard treatment therapy in relation to sexual function and hormonal plasma level.

Conclusions
A higher prevalence of sexual dysfunction was observed in the epileptic patients especially in those with uncontrolled seizures. For that reason, the issues related to sexual activity should be clarified by physicians how are involved in managing the patients suffering from epilepsy.
Idiopathic intracranial hypertension: from concise history to current management
Authors: Adnyana I Made Oka , Indah Carolin Tiara Lestari 
Published: September 2023

Abstract
Background
Idiopathic intracranial hypertension (IIH), known as benign intracranial hypertension (BIH) since the report of Quincke in 1893, was described as a rare disorder of elevated intracranial hypertension with normal cerebrospinal fluid (CSF) and without any pathology. This review describes the history, pathophysiology, management, and prognosis of IIH; hence, the clinician can provide treatment based on the known possible mechanisms.

Results
Headache and visual obscuration are the most typical reported manifestation of IIH. The pathophysiology remains unknown; however, some theories relate to its mechanism, including obesity and metabolic dysregulation. It was diagnosed based on Friedman's criteria diagnosis. The management of IIH, consisting of conservative (control body weight), medical treatment, and surgical treatment, aims to reduce the symptoms and maintain visual function.

Conclusion
The pathophysiology of IIH underlies the current approaches and management. The recurrences in 1–5 years are likely developed after treatment; thus, long-term follow-up needs to consider depending on the severity of visual loss, papilledema, and symptoms.