bluuebunny/crossref_metadata_2025_split huggingface dataset:
On one thermodynamically consistent model of clay shale swelling
Authors: Имомназаров Б.Х. , Хайдаров И.К. , Имомназаров Х.Х. 
Published: March 2023

Модифицированный вариант линейной теории пороупругости, описываемый тремя упругими параметрами, применяется к математическому моделированию сланцевого разбухания с водным электролитом. Предполагается, что сланец ведет себя как изотропная идеальная ионная мембрана, и в этом случае разбухание зависит только от полного напряжения и от химического потенциала воды в порах горной породы. Получена формула для коэффициента Пуассона, выражающаяся тремя упругими параметрами, физическими плотностями насыщенной жидкостью пористой среды, а также коэффициентом пористости. Показано, что коэффициент диффузии является функцией коэффициента межфазного трения (проницаемости) и обратно пропорционален коэффициенту пористости. Получены формулы для анализа плоской деформации вокруг ствола скважины.
A modified version of the linear poroelasticity theory described by three elastic parameters is applied to the mathematical modeling of shale swelling with an aqueous electrolyte. It is assumed that the shale behaves as an isotropic ideal ionic membrane, and in this case, swelling depends only on the total stress and on the chemical water potential in pores of the rock. A formula is obtained for the Poisson coefficient in terms of three elastic parameters, the physical densities of the saturated fluid of the porous medium, and the porosity coefficient. It is shown that the diffusion coefficient is a function of the coefficient of interfacial friction (permeability) and is inversely proportional to the coefficient of porosity. The formulas for the flat strain analysis around the wellbore were obtained.
On the solvability of the inverse problems of parameter recovery in elliptic equations
Authors: Кожанов А.И. 
Published: March 2023

Изучается разрешимость обратных задач нахождения вместе с решением $u(x, t)$ также положительного параметра $\alpha$ в дифференциальных уравнениях $$ u_{tt}+\alpha\Delta u-\beta u=f(x,t),\;\alpha u_{tt}+\Delta u-\beta u=f(x,t) $$ ($t\in(0,T)$, $x=(x_1,\dots,x_n)\in\Omega\subset\mathbb{R}^n$, $\Delta$ – оператор Лапласа по переменным $x_1,\dots,x_n$). В качестве дополнения к краевым условиям, определяющим корректную краевую задачу для эллиптических уравнений, используется условие линейного финально-интегрального переопределения. Доказываются теоремы существования и единственности регулярных (имеющих все обобщенные по С. Л. Соболеву производные, входящие в уравнение) решений.
We study solvability of the inverse problems of finding, alongside the solution $u(x, t)$, the positive parameter $\alpha$ in the differential equations $$ u_{tt}+\alpha\Delta u-\beta u=f(x,t),\;\alpha u_{tt}+\Delta u-\beta u=f(x,t) $$ Where $t\in(0,T)$, $x=(x_1,\dots,x_n)\in\Omega\subset\mathbb{R}^n$, and $\Delta$ – the Laplace operator in variables $x_1,\dots,x_n$. As a complement to the boundary conditions defining a well-posed boundary value problem for elliptic equations, we use the conditions of the linear final integral overdetermination. We prove the existence and uniqueness theorems for regular solutions, those having all generalized in the S. L. Sobolev sense derivatives in the equation.
INVESTIGATION OF NONLINEAR HIGH-AMPLITUDE LATTICE OSCILLATIONS IN AlnPtm ALLOYS
Authors: Чередниченко А.И. , Ерёмин А.М. , Васильев А.Э. , Старостенков М.Д. , Захаров П.В. 
Published: March 2023

Используя метод молекулярной динамики в работе проведено исследование существования дискретного бризера в модельных кристаллах на основе Al и Pt с различной стехиометрией. В этих кристаллах рассчитан фононный спектр, а так же проведен анализ возможности существования дискретных бризеров в объёме кристалла на атомах Al. Моделирование осуществлялось на основе применения компьютерной программы LAMMPS Molecular Dynamics Simulator. Модели сплавов Al и Pt с различной кристаллической структурой созданы на основе материалов из базы данных The Materials Project. Кристаллы необходимых для моделирования размеров получены на основе элементарных ячеек из базы материалов с помощью приложения Atomsk. Для расчетов межатомного взаимодействия применялся ЕАМ-потенциал, который был получен методом погружённого атома.
Using the method of molecular dynamics, we studied the existence of a discrete breather in model crystals based on Al and Pt with different stoichiometry. In these crystals, the phonon spectrum was calculated, and an analysis was made of the possibility of the existence of discrete breathers in the bulk of the crystal on Al atoms. The simulation was carried out on the basis of the computer program LAMMPS Molecular Dynamics Simulator. Models of Al and Pt alloys with different crystal structures are based on materials from The Materials Project database. The crystals of the sizes necessary for modeling were obtained on the basis of elementary cells from the database of materials using the Atomsk application. To calculate the interatomic interaction, the EAM potential was used, which was obtained by the embedded atom method.
Effectiveness of Internal Audit Implementation at BPJS of Employment
Authors: Fachrurozy Muhammad Edly , Nurafiah Nunuy , Deliana Deliana , Hasibuan Raya Puspa Sari 
Published: March 2023

Abstract This study aims to analyze the effectiveness of implementation of internal audit in BPJS Ketenagakerjaan. This study involved 8 informants consisting of the Assistant Head of the Internal Audit Department, Internal Auditor, and the Branch Head. Measurement of the effectiveness of internal audit in this study uses the IPPF Practice Guide: Measuring Internal Audit Effectiveness and Efficiency from the Institute of Internal Auditors which consists of basic measures, services to stakeholders, technical development, innovation, and human resource development. The results showed that in a basic measure, clients (auditees) felt satisfy with the services provided by SPI. Internal auditors also feel satisfied in terms of the field of work and salary or facilities provided by management. The findings obtained by internal auditors at this time are more on administrative errors and do not lead to fraud. The recommendations by the internal auditor are always followed up by the auditee and this is also the support of management. Repeated findings are still at a reasonable level and the numbers are not many. The existence of SPI greatly helps management in achieving organizational goals. SPI allocates a budget for internal auditor technical development, but this is done in turn because of budget constraints. Internal auditors are also involved in professional organizations, but their nature is only passive. All internal auditors already have certification and auditor rotation is carried out in accordance with the needs and management policies. Keywords: internal audit, effectiveness of internal audit, internal audit department
Precursors, pathways of carcinogenesis and molecular markers of vulvar squamous cell carcinoma. Literature review
Authors: Pakharukova M. I. , Yushkov B. G. , Beikin Ya. B. 
Published: March 2023

The review analyzes and summarizes the results of the studies on the pathogenesis of vulvar squamous cell carcinoma and its diagnostic features, reviews precursors and molecular subtypes of carcinomas. Despite the relatively low incidence of this tumor, over the past few decades, there has been an upward trend in its incidence, including the incidence among young women. According to the latest World Health Organization classification of lower genital tumors from 2020, vulvar squamous cell carcinoma is divided into human papillomavirus (HPV) associated and HPV-independent. While these carcinomas are often morphologically similar, their mechanisms of carcinogenesis, precursors, and clinical outcomes are different. Just the detection of virus DNA in a tumor is not enough to establish HPV status. Meanwhile immunohistochemical detection of the expression of p16 and p53 proteins allows not only to separate two pathogenetic pathways of carcinogenesis, but also to identify its molecular subtypes. The data on the possible use of p16 and p53 expression as the disease prognosis molecular markers have been obtained. Currently, the tactics of treatment and monitoring patients does not depend on the HPV status of carcinoma; however, the results of recent studies suggest that women with HPV positive vulvar cancer have significantly higher survival rates and a lower risk of recurrence. Understanding the mechanisms of carcinogenesis and improving its diagnosis will advance the assessment of the individual risk of the progression of precancerous lesions, as well as the outcome and the occurrence of tumor recurrence.
Features of the local cytokine profile of patients with bullous keratopathy by using personalized therapy with cellular technologies
Authors: Denisko M. S. , Zhigalskaya T. A. , Krivosheina O. I. 
Published: March 2023

Background. Today we have active development of ophthalmic surgery, but the role of cytokines in the pathogenesis of bullous keratopathy of the cornea remains insufficiently studied at present.The aim. To study the dynamics of the local cytokine profile in bullous keratopathy by using personalized treatment with suspension of autologous blood mononuclears.Material and methods. Two groups of patients with bullous keratopathy were formed: the main group (30 people, 30 eyes), who received an intrastromal injection of a suspension of autologous blood mononuclears and comparison (28 people, 28 eyes), who received a course of pharmacotherapy. The level of interleukins (IL) – IL-10, IL-4, IL-6, IL-1ß, transforming growth factor beta-2 (TGF-β2), tumor necrosis factor alpha (TNF-α) was determined in the lacrimal fluid of the patient’s eye by enzyme immunoassay.Results. All patients before treatment showed an increase of IL-1ß in the lacrimal fluid by 3.3 times, IL-6 – by 4.2 times, TNF-α – by 2.0 times (p < 0.05); an increase in the level of IL-4, IL-10 and TGF-β2 by 1.1 times (p > ˂ 0.05). In the main group, after treatment, there was a decrease in IL-1ß by 2.0 times, IL-6 – by 2.1 times and TNF-α – by 1.8 times, and an increase in IL-10 by 1.5 times, IL-4 – by 1.9 times, TGF-β2 – by 1.4 times (p < 0.05), persisting for 12 months. There was a short-term decrease of IL-1ß by 1.7 times, IL-6 and TNF-α – by 1.2 times and an increase of IL-10, IL-4, TGF-β2 by 1.2 times (p >< 0.05) in the comparison group which then reached the initial values. Conclusion. There is an imbalance in the system of pro- and anti-inflammatory cytokines in bullous keratopathy in the lacrimal fluid. Injection of autologous mononuclear cells in the stroma of the cornea reduces the severity of the imbalance of the local cytokine system compared to the course of pharmacotherapy. Key words: bullous keratopathy, cellular technologies, autologous mononuclear leukocytes, cytokines>˂ 0.05), persisting for 12 months. There was a short-term decrease of IL-1ß by 1.7 times, IL-6 and TNF-α – by 1.2 times and an increase of IL-10, IL-4, TGF-β2 by 1.2 times (p ˂ 0.05) in the comparison group which then reached the initial values.Conclusion. There is an imbalance in the system of pro- and anti-inflammatory cytokines in bullous keratopathy in the lacrimal fluid. Injection of autologous mononuclear cells in the stroma of the cornea reduces the severity of the imbalance of the local cytokine system compared to the course of pharmacotherapy.
Prevalence of malocclusions under conditions of prolonged introduction of systemic fluorides in variable concentrations: Literature review
Authors: Belyaev V. V. , Gavrilova O. A. , Belyaev I. V. , Myalo O. A. , El-Aydi M. A. 
Published: March 2023

The pathogenesis of malocclusions, which are common among the population of all countries, is well represented in the professional literature. The occurrence of malocclusions is associated with genetic and various environmental factors. Among the latter, fluorides which affect the prevalence of some dental diseases are of particular interest. However, there are few publications reflecting the frequency of malocclusion among the population in the regions with different levels of fluoride in drinking water. This problem seems to be significant in the context of the increasing impact of fluorine compounds on human health, including dental health.The aim of the study. To analyze the literature on the frequency of malocclusion among the population living in conditions of variable fluoride content in drinking water. A manual search of domestic and foreign literature was performed in the search databases PubMed, Medline and Google Scholar. From the initial list of publications, eighteen articles that met the inclusion criteria for the study were selected for analysis. We revealed significant variability of the research results. Some authors note a higher prevalence of malocclusions among the population under conditions of increased fluoride intake, others note a lower one, and still others did not reveal any differences between the values obtained in both samples. Most of the assessed publications did not methodologically meet modern international standards, and therefore were of little evidence.The literature data do not provide grounds for an unambiguous assessment of fluorine compounds as an environmental factor that indirectly affects the process of occlusion formation in humans and animals.The review did not allow to make a definitive conclusion on the possible impact of systemic fluorides on the prevalence and pattern of malocclusion in humans and animals. It requires the implementation of studies that comply with the principles of evidence-based medicine.
Cell-mediated and humoral immunity during COVID-19 in the Republic of Crimea
Authors: Zyablitskaya E. Yu. , Kudlay D. A. , Kolesnik S. V. , Makalish T. P. , Maksimova P. E. , Kunitskaya Yu. E. , Gritskevich O. Yu. , Golovkin I. O. , Fomochkina I. I. , Kubyshkin A. V. 
Published: March 2023

The COVID-19 (coronavirus disease 2019) pandemic has spurred the development of highly effective quantitative methods for assessing the adaptive immune response to the SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus 2) virus. In order to assess the humoral component of the immune response, various methods for detecting immunoglobulins A, M, G are widely used. ELISPOT seems to be the most accessible and effective method to assess the level of T cells that specifically respond to the SARS-CoV-2 virus antigens.The aim. To assess cell-mediated and humoral immunity in COVID-19 in residents of the Republic of Crimea.Methods. The study was performed on 24 volunteers: the presence of coronavirus antibodies was determined by ELISA method, and the presence of contact with coronavirus proteins – by the ELISPOT “TigraTest® SARS-CoV-2” method (Generium, Russia). For retrospective study of humoral immunity in the population, we assessed 10 000 ELISA tests (ECOlab IgM and IgG, Russia) performed in our laboratory for the period from July 2020 to January 2022.Results. The results show the effectiveness of using the ELISPOT method to detect latent forms of coronavirus infection. It is important to note that there is statistically significant relationship between the timing of the disease and the number of spots in both antigen panels. After vaccination against SARS-CoV-2, cell-mediated immunity lasts up to 6 months or more.Conclusions. As a result of the study, it was found that during 2021, the level of immunization of the population of the Republic of Crimea against COVID-19 has significantly increased; the proportion of residents who have positive IgG test has increased from 27 % to 87 %. The results of ELISPOT studies using a set of reagents for in vitro detection of blood T-lymphocytes that specifically respond to SARS-COV-2 virus antigens (“TigraTest® SARS-CoV-2”) showed that this method is more sensitive than ELISA in detecting latent diseases.
Pathological changes of the spleen in mice infected with influenza against the background of the use of saponin tauroside Sx1
Authors: Malygina V. Yu. , Sataieva T. P. , Makalish T. P. , Kalfa M. A. , Kubyshkin A. V. , Rybalko S. Yu. , Kirsanova M. A. 
Published: March 2023

Background. It is well known that viral infections are able to cause an imbalance of the interferon system and inhibition of cellular and phagocytic reactions of the body. One of the possible solutions of the flu treatment problem may be the application of immunomodulators of native plant origin since the influenza virus possesses a suppressive effect on cellular immunity and the interferon system.The aim. To evaluate the effect of saponin tauroside Sx1 obtained from Crimean ivy leaves on histological changes in the spleen of mice infected with influenza A/WSN/1/33(H1N1) virus.Material and methods. We used 78 male BALB/c mice weighing 16–18 g which were divided into the groups: control (K; n = 12); healthy animals treated with saponin (KS; n = 22); animals infected with influenza virus A/WSN/1/33(H1N1) (V; n = 22); infected animals treated with saponin tauroside Sx1 twice a day for 3 days (SV; n = 22). Histological studies of the spleen were performed on the 4th (subgroups V, SV, KS) and 14th day (2V, 2SV, 2KS).Results. The spleen tissue of the KS subgroup demonstrated hyperplasia of the white pulp in the form of lymphoid nodules expansion. On the 4th day in the KS subgroup a statistically significant increase in the total area of the lymphoid nodules by 3.9 times compared to the K subgroup was observed. In subgroup V, there was a sharp decrease in the area of white pulp and in 2V the lymphoid nodules zones were practically indistinguishable. Applied correction in the SV and 2SV subgroups significantly ceased the damaging effect of the virus: the lymphoid nodules area increased by 2.7 times in the 2SV subgroup compared to 2V.Conclusion. Infection with the H1N1 influenza virus leads to compensatory activation of the immune response, however, on the 14th day, a pronounced depletion of the splenic white pulp occurred. The introduction of saponin tauroside Sx1 enhanced the functional activity of the spleen due to an increase of the white pulp area.
History of biomechanical research at the Ilizarov Centre (to the 100th anniversary of Academician G.A. Ilizarov)
Authors: Shchurova E. N. , Dolganova T. I. , Dolganov D. V. , Menshchikova T. I. 
Published: March 2023

Background. Biomechanical studies of both the Ilizarov apparatus itself and the physiological system “apparatus – limb” occupy a significant place in the history of the formation and elaboration of the Ilizarov method, developed in the middle of the last century at the Kurgan Research Institute of Experimental Traumatology and Orthopaedics (nowadays – the world-famous Centre named after its creator). The analysis of the history of biomechanical research in the formation of Ilizarov method is not without interest.The aim. To analyze the history and stages of development of biomechanical research in order to substantiate the effectiveness of the Ilizarov method of transosseous osteosynthesis.Results. The national medical industry did not produce the appropriate equipment for biomechanical research in the early 1970s. That is why a group of engineers was included into the Laboratory of Clinical Physiology and Biomechanics (established in 1971) of the Ilizarov Centre, which created equipment for studying the processes in the tissues of the limbs and in the structure of the Ilizarov apparatus itself during its traction and compression impact on biological structures. The community of physicians, scientists and engineers made it possible to overcome a number of difficulties and problems. In their scientific publications and dissertations, the laboratory staff paid great attention to biomechanical research during transosseous osteosynthesis with the Ilizarov apparatus. At present, the staff of the Ilizarov Centre continues the traditions established by G.A. Ilizarov. For the first time in our country, a computer 3D video analysis of the kinematics and kinetics of orthopedic patients gait was introduced; it was supplemented with embedded software for the preparation of a clinical report of human gait biomechanics.Conclusions. The initial stage of the biomechanical research at the Ilizarov Centre included the creation of the research equipment. Subsequently, the biomechanical studies carried out by the staff of the Centre for almost half a century have shown an applied and functional result of the realization of general biological regularities of the Ilizarov’s discovery. At present, the biomechanical research continues at a higher level with the use of modern high-tech equipment.
Prospects for using CRISPR-Cas9 system in the treatment of human viral diseases
Authors: Ziganshin A. M. , Mulyukov A. R. , Omarov M. A. , Mudrov V. A. , Khalitova R. Sh. 
Published: March 2023

The aim. To analyze the possibility of using the genetic mechanisms of CRISPR-Cas9 technology in the prevention and treatment of certain viral diseases.Materials and methods. The search for publications was carried out in Russian and foreign literature using the following search engines: RSCI, Cyberleninka, eLibrary, PubMed, Cochrane Library, etc. A review of domestic and international scientific papers on the research topic was carried out using search keywords: CRISPR, genetic engineering, genome editing, Cas9, sgRNA.Results. A review of using CRISPR-Cas9 method (“genetic scissors”) as a gene therapy for some viral diseases was carried out, and its main advantages and disadvantages were revealed. An analysis of the data of scientific studies on genetic research methods over the past decade discovers the main aspects of CRISPR-Cas9 technology, modern classification and prospects for using this technology in clinical practice for the treatment and prevention of human viral diseases. The possibilities of creating a more versatile and stable version of the CRISPR-Cas9 technology are considered. Particular attention is paid to the technological difficulties and obstacles that scientists face when implementing this system for targeted use in clinical medicine.Conclusion. One of the rapidly developing areas in science giving promising prospects for modern healthcare is genetic engineering, especially in cases where scientific developments are applied in clinical practice. The discovery of “genetic scissors” technology has revolutionized all medicine. Wide opportunities for developing new treatment methods for many viral diseases and creating conditions for their early prevention opened up for the medical community. In the future, with the introduction of this technology into clinical practice, it will become possible to treat diseases that have not previously responded to ongoing therapy and were considered incurable.