bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of early anticoagulation after endovascular treatment in patients with atrial fibrillation
Authors: Xu Yaning , Liu Chengchun , Li Wei , Nie Ximing , Huang Shuhan , Li Xiaoshu , Wu Ya , Jin Wang-Sheng , Jiang Jiaojin , Dong Jun , Yang Yi , Sun Zhiqiang , Han Wenjun , Wang Yanjiang , Liu Liping , Zhang Meng 
Published: March 2023

BackgroundThe timing for initiating anticoagulant therapy in acute ischaemic stroke (AIS) patients with atrial fibrillation who recanalised after endovascular treatment (EVT) is unclear. The objective of this study was to evaluate the effect of early anticoagulation after successful recanalisation in AIS patients with atrial fibrillation.MethodsPatients with anterior circulation large vessel occlusion and atrial fibrillation who were successfully recanalised by EVT within 24 hours after stroke in the Registration Study for Critical Care of Acute Ischemic Stroke after Recanalization registry were analysed. Early anticoagulation was defined as the initiation of unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) within 72 hours after EVT. Ultra-early anticoagulation was defined if it was initiated within 24 hours. The primary efficacy outcome was the score on the modified Rankin Scale (mRS) at day 90, and the primary safety outcome was symptomatic intracranial haemorrhage within 90 days.ResultsOverall, 257 patients were enrolled, of whom 141 (54.9%) initiated anticoagulation within 72 hours after EVT, including 111 within 24 hours. A significant shift towards better mRS scores at day 90 was associated with early anticoagulation (adjusted common OR 2.08 (95% CI 1.27 to 3.41)). Symptomatic intracranial haemorrhage was comparable between patients treated with early and routine anticoagulation (adjusted OR 0.20 (95% CI 0.02 to 2.18)). Comparison of different early anticoagulation regimens showed that ultra-early anticoagulation was more significantly associated with favourable functional outcomes (adjusted common OR 2.03 (95% CI 1.20 to 3.44)) and reduced the incidence of asymptomatic intracranial haemorrhage (OR 0.37 (95% CI 0.14 to 0.94)).ConclusionsIn AIS patients with atrial fibrillation, early anticoagulation with UFH or LMWH after successful recanalisation is associated with favourable functional outcomes without increasing the risk of symptomatic intracranial haemorrhages.Trial registration numberChiCTR1900022154.
Diagnosis and treatment outcomes from prebronchodilator spirometry performed alongside lung cancer screening in a Lung Health Check programme
Authors: Bradley Claire , Boland Alison , Clarke Louisa , Dallinson Naomi , Eckert Claire , Ellames Deborah , Finn Jonathan , Gabe Rhian , Hancock Neil , Kennedy Martyn PT , Lindop Jason , Mohamed Ayad , Mullen Gabriel , Murray Rachael L , Rogerson Suzanne , Shinkins Bethany , Simmonds Irene , Upperton Sara , Wilkinson Anne , Crosbie Philip A , Callister Matthew EJ 
Published: March 2023

IntroductionIncorporating spirometry into low-dose CT (LDCT) screening for lung cancer may help identify people with undiagnosed chronic obstructive pulmonary disease (COPD), although the downstream impacts are not well described.MethodsParticipants attending a Lung Health Check (LHC) as part of the Yorkshire Lung Screening Trial were offered spirometry alongside LDCT screening. Results were communicated to the general practitioner (GP), and those with unexplained symptomatic airflow obstruction (AO) fulfilling agreed criteria were referred to the Leeds Community Respiratory Team (CRT) for assessment and treatment. Primary care records were reviewed to determine changes to diagnostic coding and pharmacotherapy.ResultsOf 2391 LHC participants undergoing prebronchodilator spirometry, 201 (8.4%) fulfilled the CRT referral criteria of which 151 were invited for further assessment. Ninety seven participants were subsequently reviewed by the CRT, 46 declined assessment and 8 had already been seen by their GP at the time of CRT contact. Overall 70 participants had postbronchodilator spirometry checked, of whom 20 (29%) did not have AO. Considering the whole cohort referred to the CRT (but excluding those without AO postbronchodilation), 59 had a new GP COPD code, 56 commenced new pharmacotherapy and 5 were underwent pulmonary rehabilitation (comprising 2.5%, 2.3% and 0.2% of the 2391 participants undergoing LHC spirometry).ConclusionsDelivering spirometry alongside lung cancer screening may facilitate earlier diagnosis of COPD. However, this study highlights the importance of confirming AO by postbronchodilator spirometry prior to diagnosing and treating patients with COPD and illustrates some downstream challenges in acting on spirometry collected during an LHC.
Shedding light on X17: community report
Authors: Alves Daniele S. M. , Barducci Daniele , Cavoto Gianluca , Darmé Luc , Delle Rose Luigi , Doria Luca , Feng Jonathan L. , Frankenthal André , Gasparian Ashot , Goudzovski Evgueni , Gustavino Carlo , Khalil Shaaban , Kozhuharov Venelin , Krasznahorkay Attila J. , Marchi Tommaso , Meucci Manuel , Miller Gerald A. , Moretti Stefano , Nardecchia Marco , Nardi Enrico , Natal da Luz Hugo , Organtini Giovanni , Papa Angela , Perrevoort Ann-Kathrin , Petousis Vlasios , Piperno Gabriele , Raggi Mauro , Renga Francesco , Schwendimann Patrick , Sýkora Rudolf , Toni Claudio , Valente Paolo , Voena Cecilia , Wong Cheuk-Yin , Zhang Xilin 
Published: March 2023

AbstractThe workshop “Shedding light on X17” brings together scientists looking for the existence of a possible new light particle, often referred to as X17. This hypothetical particle can explain the resonant structure observed at $$\sim $$
∼
17 MeV in the invariant mass of electron-positron pairs, produced after excitation of nuclei such as $$^8\hbox {Be}$$

8

Be

and $$^4\hbox {He}$$

4

He

by means of proton beams at the Atomki Laboratory in Debrecen. The purpose of the workshop is to discuss implications of this anomaly, in particular theoretical interpretations as well as present and future experiments aiming at confirming the result and/or at providing experimental evidence for its interpretation.
The electronic, optical, and vibrational properties of Ag3X (X = S, Se) with density functional theory
Authors: Tse Geoffrey 
Published: March 2023

Using ab initio first-principles calculations, we investigate the structural, electronic, optical, and vibrational properties of Silver Sulphide Ag3S and Selenide Ag3Se with nonlocal hybrids exchange-correlation functional. With our computational predictions, we manage to classify the material to be Fermi-Dirac semi-metal, rather than Weyl metal. Our calculated results show that the electronic band in between the Fermi-Dirac cone shifts downward when we replace the element Sulphide S with Selenide Se. The obtained optical results such as absorption coefficients and dielectric functions (conductivity, reflectivity, etc.) are similar for both Ag3S and Ag3Se. A high absorption coefficient of [Formula: see text] cm[Formula: see text] has been reported, and about 50% of light is reflected. In Raman spectra, the A[Formula: see text] managed to shift downward when replacing the element X, sulphide S with selenide Se, while the A[Formula: see text] shifts upward (to higher wavelength). The rotation and vibration of the bonding between atoms have also been explained. The calculated results of Silver-VI compounds provide useful information in the exploitation of more complicated structures.
Dual Impact of IGF2 on Alveolar Stem Cell Function during Tobacco-Induced Injury Repair and Development of Pulmonary Emphysema and Cancer
Authors: Boo Hye-Jin , Min Hye-Young , Park Choon-Sik , Park Jong-Sook , Jeong Ji Yun , Lee Shin Yup , Kim Woo-Young , Lee Jae-Won , Oh Sei-Ryang , Park Rang-Woon , Lee Ho-Young 
Published: March 2023

Abstract

Pulmonary emphysema is a destructive inflammatory disease primarily caused by cigarette smoking (CS). Recovery from CS-induced injury requires proper stem cell (SC) activities with a tightly controlled balance of proliferation and differentiation. Here we show that acute alveolar injury induced by two representative tobacco carcinogens, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene (N/B), increased IGF2 expression in alveolar type 2 (AT2) cells to promote their SC function and facilitate alveolar regeneration. Autocrine IGF2 signaling upregulated Wnt genes, particularly Wnt3, to stimulate AT2 proliferation and alveolar barrier regeneration after N/B-induced acute injury. In contrast, repetitive N/B exposure provoked sustained IGF2-Wnt signaling through DNMT3A-mediated epigenetic control of IGF2 expression, causing a proliferation/differentiation imbalance in AT2s and development of emphysema and cancer. Hypermethylation of the IGF2 promoter and overexpression of DNMT3A, IGF2, and the Wnt target gene AXIN2 were seen in the lungs of patients with CS-associated emphysema and cancer. Pharmacologic or genetic approaches targeting IGF2-Wnt signaling or DNMT prevented the development of N/B-induced pulmonary diseases. These findings support dual roles of AT2 cells, which can either stimulate alveolar repair or promote emphysema and cancer depending on IGF2 expression levels.

Significance:
IGF2-Wnt signaling plays a key role in AT2-mediated alveolar repair after cigarette smoking–induced injury but also drives pathogenesis of pulmonary emphysema and cancer when hyperactivated.
Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis
Authors: Liam Chong Kin , Ahmad Azura Rozila , Hsia Te-Chun , Zhou Jianying , Kim Dong-Wan , Soo Ross Andrew , Cheng Ying , Lu Shun , Shin Sang Won , Yang James Chih-Hsin , Zhang Yiping , Zhao Jun , Berghoff Karin , Bruns Rolf , Johne Andreas , Wu Yi-Long 
Published: March 2023

Abstract

Purpose:
The final analyses of the INSIGHT phase II study evaluating tepotinib (a selective MET inhibitor) plus gefitinib versus chemotherapy in patients with MET-altered EGFR-mutant NSCLC (data cut-off: September 3, 2021).

Patients and Methods:
Adults with advanced/metastatic EGFR-mutant NSCLC, acquired resistance to first-/second-generation EGFR inhibitors, and MET gene copy number (GCN) ≥5, MET:CEP7 ≥2, or MET IHC 2+/3+ were randomized to tepotinib 500 mg (450 mg active moiety) plus gefitinib 250 mg once daily, or chemotherapy. Primary endpoint was investigator-assessed progression-free survival (PFS). MET-amplified subgroup analysis was preplanned.

Results:
Overall (N = 55), median PFS was 4.9 months versus 4.4 months [stratified HR, 0.67; 90% CI, 0.35–1.28] with tepotinib plus gefitinib versus chemotherapy. In 19 patients with MET amplification (median age 60.4 years; 68.4% never-smokers; median GCN 8.8; median MET/CEP7 2.8; 89.5% with MET IHC 3+), tepotinib plus gefitinib improved PFS (HR, 0.13; 90% CI, 0.04–0.43) and overall survival (OS; HR, 0.10; 90% CI, 0.02–0.36) versus chemotherapy. Objective response rate was 66.7% with tepotinib plus gefitinib versus 42.9% with chemotherapy; median duration of response was 19.9 months versus 2.8 months. Median duration of tepotinib plus gefitinib was 11.3 months (range, 1.1–56.5), with treatment &gt;1 year in six (50.0%) and &gt;4 years in three patients (25.0%). Seven patients (58.3%) had treatment-related grade ≥3 adverse events with tepotinib plus gefitinib and five (71.4%) had chemotherapy.

Conclusions:
Final analysis of INSIGHT suggests improved PFS and OS with tepotinib plus gefitinib versus chemotherapy in a subgroup of patients with MET-amplified EGFR-mutant NSCLC, after progression on EGFR inhibitors.
Trends in Disparities in Advanced Neuroimaging Utilization in Acute Stroke: A Population-Based Study
Authors: Vagal Achala , Sucharew Heidi , Wang Lily L. , Kissela Brett , Alwell Kathleen , Haverbusch Mary , Woo Daniel , Ferioli Simona , Mackey Jason , De Los Rios La Rosa Felipe , Mistry Eva A. , Demel Stacie L. , Coleman Elisheva , Jasne Adam S. , Walsh Kyle , Khatri Pooja , Slavin Sabreena , Star Michael , Stephens Cody , Kleindorfer Dawn 
Published: March 2023

Background:
Our primary objective was to evaluate if disparities in race, sex, age, and socioeconomic status (SES) exist in utilization of advanced neuroimaging in year 2015 in a population-based study. Our secondary objective was to identify the disparity trends and overall imaging utilization as compared with years 2005 and 2010.

Methods:
This was a retrospective, population-based study that utilized the GCNKSS (Greater Cincinnati/Northern Kentucky Stroke Study) data. Patients with stroke and transient ischemic attack were identified in the years 2005, 2010, and 2015 in a metropolitan population of 1.3 million. The proportion of imaging use within 2 days of stroke/transient ischemic attack onset or hospital admission date was computed. SES determined by the percentage below the poverty level within a given respondent’s US census tract of residence was dichotomized. Multivariable logistic regression was used to determine the odds of advanced neuroimaging use (computed tomography angiogram/magnetic resonance imaging/magnetic resonance angiogram) for age, race, gender, and SES.

Results:

There was a total of 10 526 stroke/transient ischemic attack events in the combined study year periods of 2005, 2010, and 2015. The utilization of advanced imaging progressively increased (48% in 2005, 63% in 2010, and 75% in 2015 [
P
<0.001]). In the combined study year multivariable model, advanced imaging was associated with age and SES. Younger patients (≤55 years) were more likely to have advanced imaging compared with older patients (adjusted odds ratio, 1.85 [95% CI, 1.62–2.12];
P
<0.01), and low SES patients were less likely to have advanced imaging compared with high SES (adjusted odds ratio, 0.83 [95% CI, 0.75–0.93];
P
<0.01). A significant interaction was found between age and race. Stratified by age, the adjusted odds of advanced imaging were higher for Black patients compared with White patients among older patients (>55 years; adjusted odds ratio, 1.34 [95% CI, 1.15–1.57];
P
<0.01), but no racial differences among the young.

Conclusions:
Racial, age, and SES-related disparities exist in the utilization of advanced neuroimaging for patients with acute stroke. There was no evidence of a change in trend of these disparities between the study periods.
Genetically Proxied CRP (C-Reactive Protein) Levels and Lobar Intracerebral Hemorrhage Risk
Authors: Myserlis Evangelos Pavlos , Anderson Christopher D. , Georgakis Marios K. 
Published: March 2023

Background:
Recent evidence suggests that higher CRP (C-reactive protein) levels are associated with lower risk of Alzheimer disease, speculating that CRP might be involved in Aβ clearance mechanisms. Testing this hypothesis, we explored whether genetically proxied CRP levels are also associated with lobar intracerebral hemorrhage (ICH), commonly caused by cerebral amyloid angiopathy.

Methods:

We used 4 genetic variants within the
CRP
gene that explain up to 64% of the variance of circulating CRP levels and explored in 2-sample Mendelian randomization analyses associations with risk of any, lobar, and deep ICH (1545 cases and 1481 controls).

Results:
Higher genetically proxied CRP levels were associated with lower odds of lobar ICH (odds ratio per SD increment in CRP, 0.45 [95% CI, 0.25–0.73]) but not deep ICH (odds ratio, 0.72 [95% CI, 0.45–1.14]). There was evidence of colocalization (posterior probability of association, 72.4%) in the signals for CRP and lobar ICH.

Conclusions:
Our results provide supportive evidence that high CRP levels may have a protective role in amyloid-related pathology.
Atmospheric Circulation Patterns Associated with Extreme Wind Events in Canadian Cities
Authors: Morris Michael , Kushner Paul J. , Moore G. W. K. , Mercan Oya 
Published: March 2023

Abstract
Extreme near-surface wind speeds in cities can have major societal impacts but are not well represented in climate models. Despite this, large-scale dynamics in the free troposphere, which models resolve better, could provide reliable constraints on local extreme winds. This study identifies synoptic circulations associated with midlatitude extreme wind events and assesses how resolution affects their representation in analysis products and a climate model framework. Composites of reanalysis (ERA5) sea level pressure and upper-tropospheric winds during observed extreme wind events reveal distinct circulation structures for each quadrant of the surface-wind rose. Enhanced resolution of the analysis product (ERA5 versus the higher-resolution ECMWF Operational Analysis) reduced wind speed biases but has little impact on capturing occurrences of wind extremes seen in station observations. Composite circulations for surface wind extremes in a climate model (CESM) skillfully reproduce circulations found in reanalysis. Regional refinement of CESM over a region centered on southern Ontario, Canada, using variable resolution (VR-CESM) improves representation of surface ageostrophic circulations and the strength of vertical coupling between upper-level and near-surface winds. We thus can distinguish situations for which regional refinement (dynamical downscaling) is necessary for realistic representation of the large-scale atmospheric circulations associated with extreme winds, from situations where the coarse resolution of standard GCMs is sufficient.

Significance Statement
In this study we identify the large-scale atmospheric circulation patterns that drive extreme wind speeds in Canadian cities, and how well numerical climate models, which are used for producing climate change projections, represent these circulation patterns. Climate models do not simulate local winds as accurately as larger-scale phenomena, so this work can help identify useful information that models contain regarding extreme winds. For cities in eastern Canada, a benchmark model generally performs well, but a model with refined spatial resolution over southern Ontario improves agreement with patterns for observed extreme winds in that region.
Completeness of Race and Ethnicity Reporting in Person-Level COVID-19 Surveillance Data, 50 States, April 2020–December 2021
Authors: Erickson Scott , Bokota Rachael , Doroshenko Christine , Lewandowski Kate , Osei Kojo , Flannery Kaeli , Dominguez Adrian 
Published: March 2023

Objectives: Black, Indigenous, and People of Color have borne a disproportionate incidence of COVID-19 cases in the United States. However, few studies have documented the completeness of race and ethnicity reporting in national COVID-19 surveillance data. The objective of this study was to describe the completeness of race and ethnicity ascertainment in person-level data received by the Centers for Disease Control and Prevention (CDC) through national COVID-19 case surveillance. Methods: We compared COVID-19 cases with “complete” (ie, per Office of Management and Budget 1997 revised criteria) data on race and ethnicity from CDC person-level surveillance data with CDC-reported aggregate counts of COVID-19 from April 5, 2020, through December 1, 2021, in aggregate and by state. Results: National person-level COVID-19 case surveillance data received by CDC during the study period included 18 881 379 COVID-19 cases with complete ascertainment of race and ethnicity, representing 39.4% of all cases reported to CDC in aggregate (N = 47 898 497). Five states (Georgia, Hawaii, Nebraska, New Jersey, and West Virginia) did not report any COVID-19 person-level cases with multiple racial identities to CDC. Conclusion: Our findings highlight a high degree of missing data on race and ethnicity in national COVID-19 case surveillance, enhancing our understanding of current challenges in using these data to understand the impact of COVID-19 on Black, Indigenous, and People of Color. Streamlining surveillance processes to decrease reporting incidence and align reporting requirements with an Office of Management and Budget–compliant collection of data on race and ethnicity would improve the completeness of data on race and ethnicity for national COVID-19 case surveillance.
Electrosynthesis of silver metallonanocomposites in the 1-vinyl-1.2.4-triazole copolymer matrix with methacrylic acid
Authors: Sargsyan SH , Sargsyan AS , Khizantsyan KM , Aghajanyan IG , Sargsyan TS , Margaryan KS , Pompella A 
Published: March 2023

Silver nanocomposites were synthesized by the electrochemical method in the matrix of a copolymer of 1-vinyl-1,2,4-triazole with methacrylic acid, by combining the process of electrochemical polymerization with cathodic precipitation of metals on metal electrodes. In the electronic spectra of nanocomposites, absorption bands appear with a maximum in the region of 417–421 nm, which is typical for systems with zero valence silver. The IR spectra show that the polymer structure hardly changes during the formation of nanocomposites and films. The presence of silver in the amorphous polymer phase is indicated by the results of X-ray diffraction studies. The silver content in nanocomposites is 0–9%, which leads to an increase in the viscosity of nanocomposite solutions compared to solutions of the initial copolymers. Transmission electron microscopy data show that the synthesized nanocomposites consist of particles with a diameter of 1–12 nm, predominantly spherical.
Ethics and frontline nursing during COVID-19: A qualitative analysis
Authors: O’Mathúna Dónal , Smith Julia , Zadvinskis Inga M , Monturo Cheryl , Kelley Marjorie M , Tucker Sharon , Miller Pamela S , Norful Allison A , Zellefrow Cindy , Chipps Esther 
Published: March 2023

Background Nurses experienced intense ethical and moral challenges during the COVID-19 pandemic. Our 2020 qualitative parent study of frontline nurses’ experiences during the COVID-19 pandemic identified ethics as a cross-cutting theme with six subthemes: moral dilemmas, moral uncertainty, moral distress, moral injury, moral outrage, and moral courage. We re-analyzed ethics-related findings in light of refined definitions of ethics concepts. Research aim To analyze frontline U.S. nurses’ experiences of ethics during the COVID-19 pandemic. Research design Qualitative analysis using a directed content methodology. Participants and research context The study included 43 nurses from three major metropolitan academic medical centers and one community hospital in the northeastern, mid-Atlantic, midwestern, and western United States. Ethical considerations Participant privacy and data confidentiality were addressed. Findings Moral dilemmas arose from many situations, most frequently related to balancing safety and patient care. Moral uncertainty commonly arose from lacking health information or evidence about options. Moral distress occurred when nurses knew the right thing to do, but were prevented from doing so, including with end-of-life issues. Moral injury (accompanied by suffering, shame, or guilt) occurred after doing, seeing, or experiencing wrongdoing, often involving authority figures. Nurses expressed moral outrage at events and people within and outside healthcare. Despite difficult ethical situations, some nurses exemplified moral courage, sometimes by resisting policies they perceived as preventing compassionate care, guided by thinking about what was best for patients. Discussion This content analysis of ethics-related subthemes revealed conceptual characteristics and clarified distinctions with corresponding exemplars. Conceptual clarity may inform responses and interventions to address ethical quandaries in nursing practice. Conclusions Ethics education in nursing must address the moral dilemmas of pandemics, disasters, and other crises. Nurses need time and resources to heal from trying to provide the best care when no ideal option was available.