bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENILAIAN KRITERIA GREEN BUILDING PADA FAKULTAS TEKNIK UNIVERSITAS PATTIMURA
Authors: Buyang Christy Gery , Sangadji Fauzan 
Published: June 2023

Krisis energi Pemanasan global merupakan isu fenomenal saat ini dan menjadi salah satu tantangan dunia termasuk di Indonesia. Krisis energi sedang mendapat perhatian khusus bagi negara-negara di dunia, karena kebutuhan energi yang terus mengalami peningkatan seiring dengan meningkatnya populasi penduduk. Di samping itu pemanasan global disebabkan oleh beberapa faktor, salah satunya adalah tidak ramahnya pembangunan yang berdampak bagi lingkungan. Konsep green construction dan green building merupakan solusi untuk mengurangi pemanasan global dan krisis energi dalam lingkup Bangunan Teknik Sipil. . Studi kasus yang digunakan adalah bangunan dalam tahap operasional dan pemeliharaan yaitu gedung Fakultas Teknik Universitas Pattimura. Metode penelitian yang digunakan pada gedung Fakultas Teknik adalah analisis green building berdasarkan perangkat penilaian greenship existing building versi 1.1. Tujuan dari penelitian ini sdalah untuk melakukan pengkajian kondisi eksisting dan kesesuaian gedung Fakultas Teknik Universitas Pattimura serta memberikan rekomendasi terkait usaha perbaikan Gedung Fakultas Teknik Universitas Pattimura terhadap konsep Green Building dengan standar Greenship Existing Building v.1.1. Dari tujuan tersebut didapatkan hasil penelitian yaitu Metode green building ini terdapat 6 kategori yaitu tepat guna lahan (ASD) emperoleh 17 poin, efisiensi dan konservasi energi (EEC) memperoleh 3 poin, konservasi air (WAC) memperoleh 2 poin, sumber dan siklus material (MRC) memperoleh 6 poin, kesehatan dan kenyamanan dalam ruang (IHC) memperoleh 14 poin dan manajemen lingkungan bangunan (BEM) tidak dapat memperoleh poin. Dari 42 kriteria yang ada dalam kategori Greenship, gedung teknik unpatti memperoleh total poin sebesar 42 dari 177 poin maksimal, sehingga gedung fakultas teknik memperoleh predikat perunggu dengan jumlah poin sebesar 42 poin.
PENGARUH PENAMBAHAN ASPAL TERHADAP STABILITAS MARSHALL PADA MATERIAL RECLAIMED ASPHALT PAVEMENT (RAP) DI RUAS JALAN JENDERAL SUDIRMAL – RIJALI KOTA AMBON
Authors: Masri Yumin , Siahaya Vera Th. C. , Istia Penina 
Published: June 2023

Penanganan kerusakan jalan dengan cara pembongkaran lapis permukaan jalan lama dengan alat Cold Milling Machine (CMM) untuk memperbaiki nilai daerah permukaan jalan. Penelititan ini menggunakan cara daur ulang dari material Reclaimed Asphalt Pavement (RAP) hasil bongkaran dengan alat Cold Milling Machine (CMM). Tujuan penelitian mengevaluasi karakteristik aspal beton pada campuran panas dengan menggunakan kembali material Reclaimed Asphalt Pavement (RAP) hasil dari ekstraksi dan menambahkan material yang baru berupa agregat dan Aspal Pen 60/70 sehingga dapat menghasilkan campuran dengan kinerja yang baik. Metode eksperimen, dimana kegiatan penelitian dilakukan di laboratorium dan jenis pengujian yaitu pengujian Marshall untuk mendapatkan nilai stabilitas dan flow. Cara pengujian untuk mendapatkan nilai stabilitas dan flow yaitu dengan membaca nilai arloji pada alat Marshall. Pengujian yang akan dilakukan mengacu pada Spesifikasi Bina Marga 2018. Hasil dari penelitian diperoleh nilai karakteristik campuran beraspal daur ulang AC-WC dengan penggunaan material Reclaimed Asphalt Pavement (RAP) 20% dan penambahan aspal Pen 60/70. Berdasarkan hasil analisis terhadap penggunaan material RAP 20% dengan formulasi batu pecah 10/20 = 19,10%, batu pecah 5/10 = 32%, pasir = 20%, abu batu 8,9% dan lima variasi kadar aspal Pen 60/70 diperoleh nilai Kadar Aspal Optimum (KAO) = 6%. Karakteristik campuran dengan pengunaan RAP 20% dengan niai rata – rata yang di peroleh yaitu nilai VIM = 4,28%, nilai VMA = 15,89%, nilai VFB = 72,91%, nilai stabilitas marshall = 1.067,43 kg, nilai flow =3.56 mm, nilai marshall Quotient = 301,91 kg/mm dan memenuhi batas spesifikasi Bina Marga 2018 untuk campuran laston AC-WC.
Patient navigation across the cancer care continuum: An overview of systematic reviews and emerging literature
Authors: Chan Raymond J. , Milch Vivienne E. , Crawford‐Williams Fiona , Agbejule Oluwaseyifunmi Andi , Joseph Ria , Johal Jolyn , Dick Narayanee , Wallen Matthew P. , Ratcliffe Julie , Agarwal Anupriya , Nekhlyudov Larissa , Tieu Matthew , Al‐Momani Manaf , Turnbull Scott , Sathiaraj Rahul , Keefe Dorothy , Hart Nicolas H. 
Published: June 2023

AbstractPatient navigation is a strategy for overcoming barriers to reduce disparities and to improve access and outcomes. The aim of this umbrella review was to identify, critically appraise, synthesize, and present the best available evidence to inform policy and planning regarding patient navigation across the cancer continuum. Systematic reviews examining navigation in cancer care were identified in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Cumulative Index of Nursing and Allied Health (CINAHL), Epistemonikos, and Prospective Register of Systematic Reviews (PROSPERO) databases and in the gray literature from January 1, 2012, to April 19, 2022. Data were screened, extracted, and appraised independently by two authors. The JBI Critical Appraisal Checklist for Systematic Review and Research Syntheses was used for quality appraisal. Emerging literature up to May 25, 2022, was also explored to capture primary research published beyond the coverage of included systematic reviews. Of the 2062 unique records identified, 61 systematic reviews were included. Fifty‐four reviews were quantitative or mixed‐methods reviews, reporting on the effectiveness of cancer patient navigation, including 12 reviews reporting costs or cost‐effectiveness outcomes. Seven qualitative reviews explored navigation needs, barriers, and experiences. In addition, 53 primary studies published since 2021 were included. Patient navigation is effective in improving participation in cancer screening and reducing the time from screening to diagnosis and from diagnosis to treatment initiation. Emerging evidence suggests that patient navigation improves quality of life and patient satisfaction with care in the survivorship phase and reduces hospital readmission in the active treatment and survivorship care phases. Palliative care data were extremely limited. Economic evaluations from the United States suggest the potential cost‐effectiveness of navigation in screening programs.
Survival outcomes used to validate version 9 of the American Joint Committee on Cancer staging system for appendiceal cancer
Authors: Janczewski Lauren M. , Browner Amanda E. , Cotler Joseph H. , Nelson Heidi , Kakar Sanjay , Carr Norman J. , Hanna Nader N. , Holowatyj Andreana N. , Goldberg Richard M. , Washington M. Kay , Asare Elliot A. , Overman Michael J. ,   the American Joint Committee on Cancer Expert Panel on Cancers for the Lower Gastrointestinal Appendix Disease Site
Published: June 2023

AbstractThe standard for cancer staging in the United States for all cancer sites, including primary carcinomas of the appendix, is the American Joint Committee on Cancer (AJCC) staging system. AJCC staging criteria undergo periodic revisions, led by a panel of site‐specific experts, to maintain contemporary staging definitions through the evaluation of new evidence. Since its last revision, the AJCC has restructured its processes to include prospectively collected data because large data sets have become increasingly robust and available over time. Thus survival analyses using AJCC eighth edition staging criteria were used to inform stage group revisions in the version 9 AJCC staging system, including appendiceal cancer. Although the current AJCC staging definitions were maintained for appendiceal cancer, incorporating survival analysis into the version 9 staging system provided unique insight into the clinical challenges in staging rare malignancies. This article highlights the critical clinical components of the now published version 9 AJCC staging system for appendix cancer, which (1) justified the separation of three different histologies (non‐mucinous, mucinous, signet‐ring cell) in terms of prognostic variance, (2) demonstrated the clinical implications and challenges in staging heterogeneous and rare tumors, and (3) emphasized the influence of data limitations on survival analysis for low‐grade appendiceal mucinous neoplasms.
Indigenous ruminant production scenario in a selected cluster area of Bangladesh
Authors: Shahjahan Md , Bhuiyan AKFH 
Published: June 2023

A household survey was conducted in a preselected rural area (279 households) of Mymensingh district in Bangladesh to know the overall production and husbandry practices regarding indigenous ruminant farming and their future outlook. Data were analyzed following descriptive statistics. The average cattle (144 HHs) and goat (63 HHs) distribution per household were 1.83 and 2.14, respectively. Daily milk production of cattle and goat recorded 1.47 and 0.24 liters including the lactation period 201.98 and 87.21 days. Most of the farmers housed their cattle (88.19%) and goat (55.55%) outside the dwelling. Only 2.08% farmers purchased feed for cattle. Natural and uncontrolled breeding observed for all ruminants in the studied area. Digestive disorder (blot) in cattle (12.50%) and goat (14.29%) identified as one of the major problems in the studied areas. Vaccination practice followed very limited owners of cattle (19.44%) and goat (4.76%). Proper initiative, funding, farm-based training to educated farmers including modern animal husbandry practices could increase indigenous ruminant population in the rural area of Bangladesh.
Asian Australas. J. Biosci. Biotechnol. 2016, 1 (3), 552-556
“No Walk, No Work”
Authors: Ramos Maria Regina , Almeida Teresa , Loureiro Domingos 
Published: June 2023

Resumo: O presente artigo reflete em torno do modo como, no contexto da Arte Atual, o ato ou ação do “caminhar” se tornou numa importante modalidade prática do pensamento para os territórios da teoria e da prática artística. À luz destas ideias, que tomam a caminhada enquanto instrumento de experimentação estética, procurar-se-á refletir acerca do seu uso, revisando alguns momentos da História da Arte, com o intuito de, a partir do trabalho de alguns autores, perspetivar essa linha de pensamento que unifica num só raciocínio - o envolvimento fenomenológico, afetivo e cinestésico do artista com o lugar, - e as questões estratégicas de intervenção e transfiguração física, simbólica e conceptual do território.
Palavras-chave: Caminhada; Natureza; Percurso; Arte; “Land Walk”
The evolution of resource distribution, slow diffusion, and dispersal strategies in heterogeneous populations
Authors: Zahan Ishrat , Kamrujjaman Md. , Abdul Alim Md. , Shahidul Islam Md. , Khan Taufiquar 
Published: June 2023

Population diffusion in river-ocean ecologies and for wild animals, including birds, mainly depends on the availability of resources and habitats. This study explores the dynamics of the resource-based competition model for two interacting species in order to investigate the spatiotemporal effects in a spatially distributed heterogeneous environment with no-flux boundary conditions. The main focus of this study is on the diffusion strategy, under conditions where the carrying capacity for two competing species is considered to be unequal. The same growth function is associated with both species, but they have different migration coefficients. The stability of global coexistence and quasi-trivial equilibria are also studied under different conditions with respect to resource function and carrying capacity. Furthermore, we investigate the case of competitive exclusion for various linear combinations of resource function and carrying capacity. Additionally, we extend the study to the instance where a higher migration rate negatively impacts population growth in competition. The efficacy of the model in the cases of one- and two-dimensional space is also demonstrated through a numerical study.AMS subject classification 201092D25, 35K57, 35K50, 37N25, 53C35.
Diagnostic performance and clinical impact of blood metagenomic next-generation sequencing in ICU patients suspected monomicrobial and polymicrobial bloodstream infections
Authors: Liu Qilong , Liu Xiaojing , Hu Bingxue , Xu Huan , Sun Rongqing , Li Pengfei , Zhang Yunwei , Yang Hongfu , Ma Ning , Sun Xiaoge 
Published: June 2023

IntroductionEarly and effective application of antimicrobial medication has been evidenced to improve outcomes of patients with bloodstream infection (BSI). However, conventional microbiological tests (CMTs) have a number of limitations that hamper a rapid diagnosis.MethodsWe retrospectively collected 162 cases suspected BSI from intensive care unit with blood metagenomics next-generation sequencing (mNGS) results, to comparatively evaluate the diagnostic performance and the clinical impact on antibiotics usage of mNGS.Results and discussionResults showed that compared with blood culture, mNGS detected a greater number of pathogens, especially for Aspergillus spp, and yielded a significantly higher positive rate. With the final clinical diagnosis as the standard, the sensitivity of mNGS (excluding viruses) was 58.06%, significantly higher than that of blood culture (34.68%, P&lt;0.001). Combing blood mNGS and culture results, the sensitivity improved to 72.58%. Forty-six patients had infected by mixed pathogens, among which Klebsiella pneumoniae and Acinetobacter baumannii contributed most. Compared to monomicrobial, cases with polymicrobial BSI exhibited dramatically higher level of SOFA, AST, hospitalized mortality and 90-day mortality (P&lt;0.05). A total of 101 patients underwent antibiotics adjustment, among which 85 were adjusted according to microbiological results, including 45 cases based on the mNGS results (40 cases escalation and 5 cases de-escalation) and 32 cases on blood culture. Collectively, for patients suspected BSI in critical condition, mNGS results can provide valuable diagnostic information and contribute to the optimizing of antibiotic treatment. Combining conventional tests with mNGS may significantly improve the detection rate for pathogens and optimize antibiotic treatment in critically ill patients with BSI.
Predicting food craving in everyday life through smartphone-derived sensor and usage data
Authors: Schneidergruber Thomas , Blechert Jens , Arzt Samuel , Pannicke Björn , Reichenberger Julia , Arend Ann-Kathrin , Ginzinger Simon 
Published: June 2023

BackgroundFood craving relates to unhealthy eating behaviors such as overeating or binge eating and is thus a promising target for digital interventions. Yet, craving varies strongly across the day and is more likely in some contexts (external, internal) than in others. Prediction of food cravings ahead of time would enable preventive interventions.ObjectiveThe objective of this study was to investigate whether upcoming food cravings could be detected and predicted from passive smartphone sensor data (excluding geolocation information) without the need for repeated questionnaires.MethodsMomentary food craving ratings, given six times a day for 14 days by 56 participants, served as the dependent variable. Predictor variables were environmental noise, light, device movement, screen activity, notifications, and time of the day recorded from 150 to 30 min prior to these ratings.ResultsIndividual high vs. low craving ratings could be predicted on the test set with a mean area under the curve (AUC) of 0.78. This outperformed a baseline model trained on past craving values in 85% of participants by 14%. Yet, this AUC value is likely the upper bound and needs to be independently validated with longer data sets that allow a split into training, validation, and test sets.ConclusionsCraving states can be forecast from external and internal circumstances as these can be measured through smartphone sensors or usage patterns in most participants. This would allow for just-in-time adaptive interventions based on passive data collection and hence with minimal participant burden.
Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease
Authors: Gulbins Anne , Horstmann Mareike , Daser Anke , Flögel Ulrich , Oeverhaus Michael , Bechrakis Nikolaos E. , Banga J. Paul , Keitsch Simone , Wilker Barbara , Krause Gerd , Hammer Gary D. , Spencer Andrew G. , Zeidan Ryan , Eckstein Anja , Philipp Svenja , Görtz Gina-Eva 
Published: June 2023

IntroductionGraves’ disease (GD) is an autoimmune disorder caused by autoantibodies against the thyroid stimulating hormone receptor (TSHR) leading to overstimulation of the thyroid gland. Thyroid eye disease (TED) is the most common extra thyroidal manifestation of GD. Therapeutic options to treat TED are very limited and novel treatments need to be developed. In the present study we investigated the effect of linsitinib, a dual small-molecule kinase inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) and the Insulin receptor (IR) on the disease outcome of GD and TED.MethodsLinsitinib was administered orally for four weeks with therapy initiating in either the early (“active”) or the late (“chronic”) phases of the disease. In the thyroid and the orbit, autoimmune hyperthyroidism and orbitopathy were analyzed serologically (total anti-TSHR binding antibodies, stimulating anti TSHR antibodies, total T4 levels), immunohistochemically (H&amp;E-, CD3-, TNFa- and Sirius red staining) and with immunofluorescence (F4/80 staining). An MRI was performed to quantify in vivo tissue remodeling inside the orbit.ResultsLinsitinib prevented autoimmune hyperthyroidism in the early state of the disease, by reducing morphological changes indicative for hyperthyroidism and blocking T-cell infiltration, visualized by CD3 staining. In the late state of the disease linsitinib had its main effect in the orbit. Linsitinib reduced immune infiltration of T-cells (CD3 staining) and macrophages (F4/80 and TNFa staining) in the orbita in experimental GD suggesting an additional, direct effect of linsitinib on the autoimmune response. In addition, treatment with linsitinib normalized the amount of brown adipose tissue in both the early and late group. An in vivo MRI of the late group was performed and revealed a marked decrease of inflammation, visualized by 19F MR imaging, significant reduction of existing muscle edema and formation of brown adipose tissue.ConclusionHere, we demonstrate that linsitinib effectively prevents development and progression of thyroid eye disease in an experimental murine model for Graves’ disease. Linsitinib improved the total disease outcome, indicating the clinical significance of the findings and providing a path to therapeutic intervention of Graves’ Disease. Our data support the use of linsitinib as a novel treatment for thyroid eye disease.
Efficacy and safety of first-line immunotherapy plus chemotherapy in treating patients with extensive-stage small cell lung cancer: a Bayesian network meta-analysis
Authors: Zhang Tianming , Li Wenjun , Diwu Danbei , Chen Lijun , Chen Xi , Wang Hong 
Published: June 2023

BackgroundDespite numerous immunotherapy and chemotherapy regimens available for patients with extensive-stage small cell lung cancer (ES-SCLC), it remains unclear which regimen is the most effective and safest; relative studies comparing such regimens are scarce.ObjectiveThe aim of this study was to investigate the efficacy and safety of first-line immunotherapy combinations with chemotherapy for patients with extensive-stage small cell lung cancer. In addition, for the first time, comparisons among the first-line systemic regimens on OS and PFS in ES-SCLC by each time node were made.MethodsDatabases including PubMed, Embase, Cochrane Library, Scopus, Google Scholars, and ClinicalTrials.gov, and major international conferences were searched for randomized controlled trials (RCTs) regarding comparing immunotherapy combinations with chemotherapy as first-line treatments for patients with advanced ES-SCLC from inception to 1 November. Hazard ratios (HRs) and odds ratios (ORs) were generated for dichotomous variants by RStudio 4.2.1. The outcomes comprised overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and adverse events of grade 3 or higher (Grade ≥ 3 AEs).ResultsEventually, a total of nine RCTs reporting 4,352 individuals with nine regimens were enrolled. The regimens were ipilimumabnu (Ipi), atezolizumab (Atez), durvalumab plus tremelimumab (Durv-Trem), durvalumab (Durv), pembrolizumab (Pemb), adebrelimab (Adeb), serplulimab (Serp), atezolizumab plus tiragolumab (Atez-Tira), and nivolumab (Nivo). With regard to OS, serplulimab (HR = 0.63, 95% CI: 0.49 to 0.81) was found to yield the best OS benefit when compared with chemotherapy. Meanwhile, serplulimab had the highest probability (46.11%) for better OS. Furthermore, compared with chemotherapy, serplulimab significantly increased the OS rate from the 6th to the 21st month. With regard to PFS, serplulimab (HR = 0.47, 95% CI: 0.38 to 0.59) was found to yield the best PFS benefit when compared with chemotherapy. Simultaneously, serplulimab had the highest probability (94.48%) for better PFS. Serplulimab was also a long-lasting first-line regimen in both OS and PFS from a longitudinal perspective. In addition, there was no significant difference among the various treatment options for ORR and grade ≥3 AEs.ConclusionConsidering OS, PFS, ORR, and safety profiles, serplulimab with chemotherapy should be recommended as the best therapy for patients with ES-SCLC. Certainly, more head-to-head studies are needed to confirm these findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022373291.
Clinical, dermoscopic, and ultrasonic monitoring of the response to biologic treatment in patients with moderate-to-severe plaque psoriasis
Authors: Wang Juncheng , Zhu Qingli , Li Feng , Xiao Mengsu , Liu Jie 
Published: June 2023

BackgroundAssessment of therapeutic response of psoriasis has relied traditionally on clinical observation, and effective non-invasive tools are desirable.ObjectivesTo investigate the value of dermoscopy and high-frequency ultrasound (HFUS) in the monitoring of psoriatic lesions treated with biologics.MethodsPatients with moderate-to-severe plaque psoriasis treated with biologics were evaluated by clinical, dermoscopic, and ultrasonic scores at weeks 0, 4, 8, and 12. Clinical scores, including Psoriasis Area Severity Index (PASI) and target lesion score (TLS), were evaluated at representative lesions. Dermoscopy was performed to assess the red background, vessels, and scales on a 4-point scale as well as the presence of hyperpigmentation, hemorrhagic spots, and linear vessels. HFUS was performed to measure the thicknesses of the superficial hyperechoic band and subepidermal hypoechoic band (SLEB). The correlation between clinical, dermoscopic, and ultrasonic evaluation was also analyzed.ResultsIn total, 24 patients were analyzed and achieved 85.3 and 87.5% reduction of PASI and TLS, respectively, after 12 weeks of treatment. The red background, vessels, and scales scores under dermoscopy were reduced by 78.5, 84.1, and 86.5%, respectively. Some patients developed hyperpigmentation and linear vessels after treatment. Hemorrhagic dots slowly subside over the therapeutic course. Ultrasonic scores were significantly improved with an average reduction of 53.9% in superficial hyperechoic band thickness and 89.9% in SLEB thickness. TLS in the clinical variables, scales in dermoscopic variables, and SLEB in ultrasonic variables decreased the most significantly in the early stage of treatment (week 4) with 55.4, 57.7, and 59.1% (P &gt; 0.05), respectively. Most of the variables, including the red background, vessels, scales, and SLEB thickness, were strongly correlated with TLS. High correlations were also found between the SLEB thickness and the red background or vessels scores, and between the superficial hyperechoic band thickness and the scales scores.ConclusionBoth dermoscopy and HFUS were useful in the therapeutic monitoring of moderate-to-severe plaque psoriasis.