bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN INSOMNIA PADA MAHASISWA PSSKPD ANGKATAN 2016 DI FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA
Authors: Suhadi Trisa Permata , Samatra Dewa Putu Gede Purwa , Nuartha Anak Agung Bagus Ngurah 
Published: August 2023

ABSTRAK

Insomnia merupakan sebuah gangguan tidur dimana pasien mengalami keluhan tidur yang tidak memadai. Faktor-faktor yang dapat mempengaruhi kejadian insomnia antara lain adalah jenis kelamin, tingkat stres, tingkat kecemasan, tingkat depresi, konsumsi alkohol dan konsumsi kopi. Penelitian ini dilakukan untuk mengetahui hubungan antara faktor-faktor tersebut dengan kejadian insomnia pada mahasiswa PSSKPD Angkatan 2016 di Fakultas Kedokteran Universitas Udayana. Penelitian ini dilakukan secara potong lintang analitik. Bahan penelitian yang digunakan berupa hasil kuesioner gabungan: KSPBJ Insomnia Rating Scale, Depression Anxiety Stress Scale (DASS 21), dan kuesioner yang menanyakan konsumsi alkohol dan kopi. Data penelitian diolah menggunakan software IBM SPSS dan dianalisa dengan uji chi-kuadrat. Jumlah sampel penelitian yang didapatkan adalah 154 orang. Hasil penelitian didapatkan 44,15% mahasiswa mengalami insomnia. Kejadian insomnia berhubungan dengan tingkat stres (p=0,003), tingkat kecemasan (p=0,000), tingkat depresi (p=0,000), dan konsumsi kopi (p=0,029). Tidak berhubungan dengan jenis kelamin (p=0,121) dan konsumsi alkohol (p=0,409). Dapat dilakukan penelitian lebih lanjut untuk mengetahui faktor resiko terjadinya stres, kecemasan dan depresi pada mahasiswa PSSKPD Angkatan 2016 di Fakultas Kedokteran Universitas Udayana.
Kata kunci : insomnia, mahasiswa, DASS 21
Overekspresi Androgen Receptor (AR) sebagai Faktor Prediktif Respon Klinis Kemoterapi Neoadjuvan Negatif pada Triple Negative Breast Cancer
Authors: Ongko Nicolas Xavier 
Published: August 2023

Triple Negative Breast Cancer (TNBC) merupakan subtipe karsinoma payudara yang agresif yang bersifat paradoks. Sebagian TNBC memiliki respon klinis kemoterapi baik namun TNBC dengan sisa jaringan tumor paska kemoterapi neoadjuvan memiliki prognosis lebih buruk. Signal androgen dimana ekspresi AR melalui jalur genomik maupun jalur pengikatan dengan promoter G-Protein-Coupled Estrogen Receptor (GPER) menyebabkan terjadinya proliferasi dan pertumbuhan sel. Teraktivasinya jalur ini tercermin dari tingginya ekspresi AR secara imunohistokimia. Tujuan penelitian ini adalah membuktikan bahwa overekspresi AR merupakan faktor prediktif respon klinis kemoterapi neoadjuvan negatif pada TNBC.Penelitian ini dilakukan secara retrospektif dengan rancangan penelitian kasus-kontrol tidak berpasangan. Sampel penelitian adalah pasien TNBC, 23 pasien dengan respon klinis kemoterapi neoadjuvan positif sebagai kontrol dan 23 pasien dengan respon klinis kemoterapi neoadjuvan negatif sebagai kasus. Data diperoleh dari hasil biopsi yang diperiksakan secara histopatologi dan imunohistokimia ER, PR, HER2 di Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Udayana/ RSUP Sanglah dan rumah sakit lainnya di Denpasar, dari Januari 2015 sampai Desember 2020. Kemudian dilakukan pulasan imunohistokimia AR. Hasil penelitian dianalisis dengan Chi square, kemudian didapatkan Odds Ratio (OR) dengan kemaknaan pada p < 0,05. Pada penelitian ditemukan bahwa terdapat hubungan antara ekspresi AR dengan respon klinis kemoterapi neoadjuvan (OR = 4,4, IK 95% = 1,26-15,41, p = 0,017). Dari penelitian ini didapatkan pasien TNBC dengan overekspresi AR memiliki kemungkinan menunjukkan respon klinis kemoterapi neoadjuvan negatif 4,4 kali lebih tinggi dibandingkan pasien TNBC yang tidak menunjukkan overekspresi AR.
Pemeriksaan ekspresi AR penting dilakukan untuk menentukan faktor prediktif terhadap respon klinis kemoterapi neoadjuvant dan faktor prognostik serta dapat dipertimbangkan penggunaan AR inhibitor sebagai terapi target pada TNBC.
GAMBARAN TINGKAT PEMAHAMAN MENGENAI SEKSUALITAS DIKALANGAN SISWA-SISWI SMA DI DENPASAR
Authors: Pranata Havea 
Published: August 2023

ABSTRAK
Pada fase remaja terjadi banyak perubahan, termasuk perubahan organ seksual dan hormonal yang mempengaruhi perkembangan psikologis remaja. Perubahan ini seringkali mendorong remaja untuk berperilaku seksual tidak aman apabila tidak mendapatkan perhatian, pendampingan dan pengawasan dari orang tua. Misalnya hubungan seksual usia dini/pranikah, penularan penyakit seksual, bahkan yang sering kita hadapi adalah masalah kehamilan pada usia muda. Salah satu upaya dalam menurunkan permasalahan ini yaitu dengan memberi pemahaman seksual yang baik melalui orang tua, lingkungan, media massa. Namun penyajian infomasi pada media massa yang terlalu cepat dan cenderung vulgar memerlukan perhatian. Maka perlunya pemberian pemahaman seksual yang baik pada remaja. Penelitian ini dilakukan dengan tujuan mengetahui pemahaman mengenai seksualitas pada siswa-siswi SMA di Denpasar. Penelitian ini mengunakan rancangan deskriptif cross-sectional, melibatkan 100 responden yang dipilih dari siswa dan siswi SMA di Denpasar. Pengambilan data dilakukan menggunakan kuesioner yang diisi oleh responden itu sendiri pada satu waktu. Hasil penelitian menunjukkan bahwa sebanyak 69% responden memiliki pemahaman yang kurang baik mengenai informasi seksualitas. Sebanyak 97% reponden menggunakan internet sebagai salah satu sumber dalam mencari informasi yang berkaitan dengan seksual. Secara umum dapat disimpulkan bahwa kecenderungan siswa dan siswi SMA di Denpasar masih memiliki pemahaman yang kurang baik mengenai seksualitas dan sebagian besar menggunakan internet sebagai sumber informasi seksual. Diharapkan adanya intervensi berupa pendidikan seksualitas dari orang tua maupun di sekolah untuk meluruskan pemahaman seksualitas yang kurang di kalangan siswa-siswi SMA di Denpasar, Bali, sehingga dapa mengurangi dampak buruk yang merusak masa depan mereka.
EVALUATION OF SKIN SIDE EFFECTS OF RADIATION THERAPY IN ABDOMINAL AND PELVIC REGIONS: A CLINICAL ASSESSMENT
Authors: HABİBOĞLU Rahşan , KAYALI Fevziye İlknur , SARICANBAZ İrem 
Published: August 2023

Objective: This study aimed to evaluate the skin side effects of abdominal and pelvic radiation therapy. Radiation therapy is widely used in the treatment of various cancers, but it can cause significant skin changes as a side effect. These effects are classified into acute, subacute, or chronic stages depending on their timing and severity.

Material and Methods: We examined 60 patients who underwent radiation therapy between 2016 and 2018 and obtained their information from treatment records. Sixteen patients received palliative radiation therapy, while 44 patients received curative radiation therapy. Pelvic radiation therapy was administered to 41 patients, and abdominal radiation therapy was performed on 19 patients. The end point of the study was assesing skin reactions.The grading of radiation dermatitis was evaluated by using the Radiation Therapy Oncology Group / European Organization for Research and Treatment of Cancer criteria.

Results: 75% of the study population was male and 25% female. The ages of the patients ranged from 29 to 82, with a median age of 56. The grade 1 side effect rate among patients who experienced side effects was calculated as 82.75% (24 patients), while the grade 2 side effect rate was calculated as 17.24% (5 patients). These side effects were generally mild to moderate and did not significantly differ based on patient age or gender. However, patients receiving concurrent chemotherapy showed an increased frequency of skin side effects (p
MUCOEPIDERMOID CARCINOMA OF THE LIVER: A RARE, DIAGNOSTICALLY CHALLENGING CASE
Authors: AYDIN Arzu Hazal , YAMAK Seda , GÜRSOY Göktürk , OVALI ERDOĞDU İkbal , ÖZOĞUL Yusuf Bayram 
Published: August 2023

Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. It rarely occurs in other organs. Less than 20 cases of mucoepidermoid carcinoma of liver have been reported in the literature.

A 70-year-old woman with a liver mass is reported in this case report. After liver segmentectomy operation, the specimen was examined microscopically, a tumor consisting of epidermoid, mucinous, and intermediate cells was observed. It was interpreted as mucoepidermoid carcinoma. As no other focus was detected from comprehensive scanning of the patient, it was diagnosed as primary mucoepidermoid carcinoma of liver. Due to mimicking other tumors such as adenosquamous carcinoma and squamous cell carcinoma; cautious examination and differential diagnosis are important.
MİYOKARDİT/MİYOPERİKARDİT İLE BAŞVURAN HASTALARDA KARDİYAK ARİTMİLER-TEK MERKEZLİ RETROSPEKTİF BİR ÇALIŞMA
Authors: DUMAN Derya , KARPUZ Derya 
Published: August 2023

Amaç: Kalp kasının ve perikardın tutulumu ve inflamasyonu ile karakterize izole miyokardit/miyoperikardit, çoğunlukla viral bir enfeksiyon sonrası görülür. Çocuklarda miyokardit/miyoperikardit sırasında çeşitli kardiyak aritmiler görülebilir. Literatürde çocuklarda bu konu ile ilgili çalışmalar nispeten azdır. Bu çalışma ile tek bir merkezde takip edilen miyokardit/miyoperikarditli olgularda görülen aritmileri ve uyguladığımız tedavileri sunmayı amaçladık. Bir diğer hedefimiz aritmilerin hastalığın seyrine etkisini ve aritmiye yol açabilecek risk faktörlerini değerlendirmekti.

Gereç ve Yöntemler: Eylül 2021-Mart 2023 tarihleri arasında, hastanemizde miyokardit/ miyoperikardit tanısı ile takip edilen 79 olgunun dosyaları geriye dönük olarak incelendi.

Bulgular: Hastaların yaşları 2 ay-18 yıl arasında değişmekteydi. Hastaların 44’ü (%55.6) erkek, 35’i (%44.3) kız idi. Elektrokardiyografide 8/79 (%10.1) hastada bazalde uniformik ventriküler ekstrasistoller görüldü. Bir hastanın başvurusunda atriyal taşikardisi, birinde atriyal fibrilasyon, birinde sürekli ventriküler taşikardi, üç hastada ise supraventriküler taşikardi mevcuttu. Kalan hastaların holter incelemelerinde 5/79 (6.3%) hastada sürekli olmayan ventriküler taşikardi atağı ve farklı şekilllerde ventriküler ekstrasistoller izlendi, 11/79 (%13.9) hastada ise uniformik ventriküler ekstrasistol görüldü. Totalde hastaların 30/79‘unda (%37.9) aritmi görüldü. Riskli hastalara antiaritmik tedavi başlandı. Genel durumu iyi olan, sadece uniformik ventriküler ekstrasistolleri olan ve kontrol holterde sorun olmayan hastalar klinik olarak sorunsuz takip edildiler. Aritmisi olanlarla olmayanlar arasında, hastaların yatış süresi açısından belirgin bir farklılık gözlenmedi. Akut dönem sonrası iki hastada aritmi tekrarladı.

Sonuç: Miyokardit/miyoperikarditin ilk başvurusu aritmilerle olabileceği gibi, klinik seyirde sonradan karşımıza çıkabilir ve hastalar ritm açısından monitorize edilmelidir. 24 saat Holter monitorizayonu aritmileri yakalamada önemlidir. Akut dönem sonrası da aritminin tekrarlama riski nedeniyle hastalar takip edilmelidir.
Prevalence of hypertension and obesity among non-academic staff in a Nigerian University
Authors: Temitope O Akinpelu , Oladosu Gbenga , Bolanle R Olajide , Oluwatoyin E Oladeji , Agboola A Adebowale , Oluseye O Onabanjo 
Published: August 2023

Background: The aim of achieving a healthy society has motivated and led many researchers to understand the prevalence of diseases to create awareness and assess interventions’ effectiveness.
Objective: This study determines the prevalence of hypertension and obesity among the non-academic staff of the Federal University of Agriculture, Abeokuta.
Methods: The study design was descriptive and cross-sectional. 300 Non-academic staff of the institution were randomly selected and data were obtained on their sociodemographic and socioeconomic characteristics, predisposing risk factors of hypertension, anthropometry, and blood pressure measurements using a structured self-administered questionnaire and standard procedures. Data were analyzed and presented using descriptive and inferential statistics. Statistical significance was established at p<0.05.
Results: The mean age was 42±8.0years, there were more female respondents (56.0%) than male respondents (44.0%) and 76.0% of the respondents were married. Results further revealed a high prevalence of overweight and obesity (52%), pre-hypertension and hypertension (40%), and risk of abdominal obesity (84%).
Conclusion: Non-academic staff are an essential component of the workforce and workplace intervention is essential to reduce the work nature risk factor of Obesity and Hypertension to prolong lives, and boost productivity and economic growth.
The effect of intermittent fasting 5:2 on IL-6 levels in obese male employees in Jakarta
Authors: Octavia Sarah Diva , Yudhistina Karima , Prafiantini Erfi , Octovia Lily Indriani , Silvia Hardiany Novi 
Published: August 2023

Background: Obesity is a condition of excessive fat accumulation in adipose tissue. This condition causes endothelial damage, increase macrophage infiltration, and inflammation in adipose tissue. Inflammation happens due to the increase of interleukin-6 (IL-6) as a proinflammatory cytokine which responsible for the occurrence of chronic diseases. Intermittent fasting is a potentially effective method for losing weight and suggested can reduce levels of proinflammatory cytokines.
Objective: The aim of this study is to determine the effect of 5:2 intermittent fasting on IL-6 cytokine levels in obese employees in Jakarta.
Methods: This study used a cross-sectional method conducted on 50 healthy male employees aged 19–52 years with a body mass index (BMI) ≥25 kg/m2. Subjects were divided into two groups, the 5:2 intermittent fasting group and the non-fasting group. Intermittent fasting 5:2 was observed every Monday and Thursday for eight weeks. IL-6 levels were obtained through examination using an enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed by Mann Whitney and Kruskal Wallis test.
Results: The results showed that the median of IL-6 levels decreased in fasting group from 5,10 (1.06–9.81) pg/mL to 4.64 (1.00–13.39) pg/mL and increased in non-fasting group from 3.65 (1.17–38.70) pg /mL to 6.35 (2.44–19.86) pg/mL, but the change was not significant.
Conclusion: Intermittent fasting 5:2 tend to decrease IL-6 levels in obese male employees in Jakarta although the change of IL-6 level was not significant.
Students’ Perceptions and Attitudes towards the Utilization of Duolingo in EFL Learning
Authors: Irzawati Ira , Unamo Agnes Felisya 
Published: August 2023

Education sector in the 21st Century has continuously changed and relied more on technology. The evolution of the use of technology in education leads to the emergence of gamification. Duolingo is a language learning platform that provides free language courses through web and mobile apps that instills gamification aspects. The objective of this study is to investigate the students’ perceptions and attitudes towards the utilization of Duolingo in EFL learning. This descriptive study involved twenty students of a non-English education study program through purposive sampling technique. The criteria of selecting the participants were based on the participation in English Learning class and the active use Duolingo for English practice outside the course hours. The researchers employed a questionnaire and an interview to collect the data. The data of the questionnaire were analyzed quantitatively through simple percentage analysis of SPSS. Meanwhile, the data of the interview were analyzed qualitatively through Miles, et al. Model consisting of collection, classification, description, interpretation, and conclusion. The results revealed that the students provided positive feedbacks towards thirty statements of questionnaire and three questions of interview that representing their perceptions and attitudes towards the utilization of Duolingo in EFL learning. The students believed that learning English through Duolingo was easy, fun, engaging, and motivating. In short, the students had positive perceptions and attitudes towards the utilization of Duolingo in EFL learning.
Complex Connections: An investigation into the design to production model for non-standard joinery creation
Authors:   , Cormack Jordan 
Published: August 2023

<p>Improper interpretation when reading construction drawings commonly leads to re-work, unnecessary cost inflation and generally act negatively on working relationships in the construction of a project. There are however, new processes and digital workflows emerging in architectural design which reduce risks that are often associated with the traditional stages of an architectural project. Pairing these new digital workflows with contemporary fabrication methods provides a nonlinear and more reliable system of information transfer.</p>
<p>The research for this thesis will consider assembly relationships and joining details within an advanced CAD/CAM process. Specifically, it will examine how the improvement of digital based, parametric joinery can be integrated into and influence the design to manufacture pipeline. Three projects will be created using proprietary parametric software and CNC machine processes to analyse and develop the design to manufacture pipeline.</p>
<p>This thesis will focus on the joinery or detail portion of these projects – an area often not considered until the final stages of a project. Over the course of these projects the level of detail and complexity will be increased to challenge the structure of the workflow model. The three projects will attempt to re-develop efficiencies of joinery design within complex projects using computational efficiencies and machining advantages. The increasing complexity in each project will provide a chance to improve the section of workflow which controls the development of joinery and detailing.</p>
<p>Project reflection will begin to highlight areas which can be taken advantage of to integrate joinery into a project earlier. Considering the joinery and detailing relationships earlier in the process may provide reduced inefficiencies, improving the manufacturing links to production of complex architecture. </p>
Terapi rendam kaki dengan rebusan air jahe merah (zingiber officinale var rubrum rhizoma) untuk menurunkan tekanan darah pada penderita hipertensi
Authors: Laksmidewi Griselda Aramita , Mustofa Akhmad 
Published: August 2023

Hipertensi yang tidak terkontrol akan menyebabkan terjadinya komplikasi seperti penyakit jantung koroner dan stroke, gagal jantung dan kerusakan pembuluh darah retina yang mengakibatkan gangguan penglihatan. Terapi non farmakologi yang dilakukan salah satunya mengaplikasikan rendam kaki dengan rebusan air jahe merah untuk menurunkan tekanan darah yang mengalami hipertensi. Tujuan studi kasus ini untuk melakukan pengelolaan asuhan keperawatan pada klien hipertensi dengan melakukan aplikasi rendam kaki dengan rebusan air jahe merah untuk menurunkan tekanan darah. Studi kasus ini menggunakan metode deskriptif dengan pendekatan proses asuhan keperawatan. Subjek studi kasus berjumlah 2 klien yang memiliki kriteria inklusi subyek yang siap menjadi responden, yang memiliki kriteria tekanan darah sistolik ≥ 140 mmHg dan tekanan darah diastolik ≥ 90 mmHg. Variabel studi kasus yaitu tekanan darah dan diukur menggunakan Sphymanometer digital. Intervensi rendam kaki dengan rebusan air jahe merah yang dilakukan selama 5 kali tindakan dalam 5 hari berturut-turut yang dilakukan selama 15 menit dengan rebusan air jahe merah bersuhu 40℃. Hasil dari penerapan rendam kaki dengan rebusan air jahe merah yaitu Penurunan rata-rata tekanan darah sistolik pada klien studi kasus 1 yaitu 6 mmHg dan tekanan darah diastolik yaitu 5,4 mmHg. Penurunan rata-rata tekanan darah sistolik pada klien studi kasus 2 yaitu 3 mmHg dan tekanan darah diastolik yaitu 2 mmHg. Skala nyeri klien 1 dari 4 menjadi 2, dan klien 2 dari 5 menjadi 3. Intervensi ini merupakan salah satu manajemen terapi yang dapat digunakan untuk menurunkan tekanan darah pada klien hipertensi di Rumah Sakit, Klinik, maupun di rumah.
Seismic Performance of Reinforced Concrete Structures with Concrete Deficiency Caused by In-situ Quality Management Issues
Authors: Aljaafreh Areen , Alzubi Yazan , Al-Kharabsheh Eslam , Yasin Bilal 
Published: August 2023

Concrete is a widely used building material known for its cost-effectiveness and high resistance compared to alternative materials. However, uncertainties in the casting process due to variations in the environment and human error can compromise its strength, increasing the risk of collapse when subjected to seismic excitations. Previous studies have demonstrated the detrimental effects of earthquake vibrations on buildings and infrastructure. This study aims to fill the research gap by investigating the seismic behavior of reinforced concrete (RC) structures constructed with lower-quality concrete under near-fault pulse-like ground motions. The main objective of this research is to assess the impact of diminished concrete strength on structural rigidity and susceptibility to ground disturbances. Specifically, the study aims to quantify the extent of performance changes in defective structures, particularly those constructed with poor-quality concrete, in response to seismic activities. To achieve this, the research involves developing multiple finite element models and conducting nonlinear analysis to scrutinize their behavior. A key focus of the study is to compare the performance of various RC buildings with concrete defects to that of a benchmark model. This comparative analysis highlights the influence of suboptimal quality control on the nonlinear behavior of RC structures. Furthermore, the study examines the correlation between changes in building response and earthquake characteristics to provide comprehensive insights into the potential risks associated with substandard construction practices. Based on the results of this study, it was found that inadequate quality control of concrete significantly impacts the performance of RC frames subjected to pulse-like ground motions. The decrease in compressive strength of the concrete led to noticeable increases in various structural parameters, including story shear, overturning moments, story displacement, drifts, accelerations, and hysteretic energy. These findings highlight the detrimental effects of compromised concrete quality on the overall structural response. Doi: 10.28991/CEJ-2023-09-08-010 Full Text: PDF
Minimum Concentration of Stingless Bee Propolis (Trigona sp.) in Inhibiting the Growth of Dandruff Bacteria
Authors: Hasan Akhmad Endang Zainal , Artika I Made , Bagjavicenna Erlank 
Published: August 2023

Lack of confidence in men and women, one of which is when there is dandruff on the hair and scalp. Hair loss is a further symptom of the presence of white scales on the scalp that cause itching. The presence of excessive microorganisms can aggravate this dandruff. Ingredients such as ketocanozole, zinc pyrithione, selenium sulfide and sulfur are compounds commonly used in shampoo formulas. Propolis is an alternative natural ingredient to treat dandruff. The purpose of this study was to determine the minimum growth inhibitory concentration (MIC) of propolis against dandruff-causing bacteria. Dandruff-causing microbes were isolated from dandruff hair and with the well method in a petri dish, the minimum growth inhibitory concentration of propolis was determined. The microbial colonies produced were very diverse with a round shape like grapes, yellowish white in color. The concentration of 6.25% is the MIC value of propolis extract against dandruff microbes. The effectiveness values against ketoconazole and propolis X from the tested propolis extract were 223.52% and 99.59%, respectively.

Keywords: hair loss, dandruff, propolis, bacteria , Trigona