bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Care System in Goa: Analysis of Role in Sustainable Development
Authors: Ferrao e Fernandes Anna Rovina 
Published: August 2023

The notion of human well-being includes the crucial attributes of leading a healthy life free from illness and ailments and a reasonable life span. Experience shows that economic prosperity measured in terms of quantitative indicators does not always ensure enrichment in quality of life, but it is reflected in broader dimensions of well-being such as health, which is desirable in sustaining the development process. Hence evaluating the achievements on health front acquires importance.
Health policies in developing countries including India have focused on the issues related to population growth, common diseases, nutrition, disabilities, newly emerging diseases such as AIDS, occupational diseases, mental diseases and so on. Along with this earlier health agenda, increasing urbanization has thrown up new health challenges related to environment pollution, increased exposure to toxic substances in everyday life and life styles related health problems.
The paper highlights the importance of a well-managed health care system in economic development. It discusses the vital statistics indicating health status of Goa. It analyzes'the trends in health sector expenditure as a proportion of Goa's NSDP. It attempts to examine if the health system in Goa is well-equipped to face the emerging health challenges to ensure sustainable development of the economy.
Abdominal aortic aneurysm surgery with a modern method - is there anything to fear?
Authors: Krysa Tomasz , Janczewska Martyna , Bielak Alicja , Kolasa Agata , Radziejowska Zuzanna , Szklarz Magdalena , Kalicka Maria , Gryta Jakub , Iwan Karolina 
Published: August 2023

Background: Endovascular surgery for abdominal aortic aneurysms using a stent graft is the modern method of supplying these life-threatening lesions in large arterial vessels. In recent years, there have been significant improvements in the technique of performing these procedures, despite which complications are still common. In order to make progress in dealing with this problem, it is important to understand in which areas of the treatment strategy appropriate changes have not yet been implemented. Various clinical cases that describe post-operative complications of stent-graft surgery, types of post-operative complications and methods of dealing with the complication that has occurred should be analysed. And also other research papers relating to this topic. The first step is to deepen the knowledge of existing post-operative complications and the types of complications that can occur after stent-graft implantation into the abdominal aorta, as well as contemporary methods of treating complications that have already arisen.
Aim of the study: The aim of this study is to present the incidence of complications after endovascular surgery for abdominal aortic aneurysms using a stent graft, the repair methods used when a complication occurs, the types of complications and their different kinds based on a review of the literature.
Material and methods: A literature review was conducted in English-language databases, based on original articles and case reports, on post-operative complications of abdominal aortic stent-graft surgery, together with treatment methods and different types of complications arising from this procedure published between 2022 and 2023. Using the keywords: "abdominal aortic stent-graft" and "complications".
A RETROSPECTIVE AUDIT INVESTIGATING THE MDT CARE PROVIDED FOR FRAGILITY NON-HIP FEMORAL FRACTURES WITHIN A MAJOR TRAUMA CENTRE
Authors: Underwood T. , Mastan S. , O'Brien S. , Welton C. , Woodruff M. 
Published: August 2023

There has been extensive research into neck of femur fractures in the elderly. Fragility non-hip femoral fractures share many of the same challenges [1]. Surgical management is complex, patients are frail and mortality rates have been reported as high as 38% [2]. Despite this, relatively little data is available evaluating the level of MDT care provided to non-hip femoral fractures.This audit aimed to evaluate the standard of MDT care provided for patients with non-hip femoral fractures according to the NHFD key performance indicators. The following fractures were included in the dataset: distal femoral, femoral shaft and peri-prosthetic femoral. Patients under 65 were excluded. Data was retrospectively collected using post-operative and medical documentation. Performance was assessed according to five key performance indicators:Did orthogeriatrics review the patient within 72-hours?Was surgery performed within 36-hours?Was the patient weight bearing post-operatively?Was a confusion assessment completed?Was the patient discharged home?38 patients met the inclusion criteria. 84% of patients were seen by orthogeriatrics within 72 hours of admission. 32% of patients were operated on within 36-hours of admission, with time to theatre exceeding 36-hours in 92% of peri-prosthetic fractures. 37% of patients were not advised to full weight bear post operatively. 84% of patients received a confusion assessment whilst 61% of patients were discharged to their prior place of living.Our results suggest that non-hip femoral fractures do not receive the same standard of MDT care as neck of femur fractures. Greater prioritisation of resources should be given to this patient subset so that care is equivalent to hip-fracture patients. Time to surgery is a particular area for improvement, particularly in peri-prosthetic fractures, a trend that is mirrored nationally. Greater emphasis should be placed on encouraging full-weight bearing post-operatively to prevent post-surgical complications.
Findings from a pilot randomized trial of spinal decompression alone or spinal decompression plus instrumented fusion
Authors: Beresford-Cleary Nicolas J. A. , Silman Alan , Thakar Chrishan , Gardner Adrian , Harding Ian , Cooper Cushla , Cook Jonathan , Rothenfluh Dominique A. 
Published: August 2023

AimsSymptomatic spinal stenosis is a very common problem, and decompression surgery has been shown to be superior to nonoperative treatment in selected patient groups. However, performing an instrumented fusion in addition to decompression may avoid revision and improve outcomes. The aim of the SpInOuT feasibility study was to establish whether a definitive randomized controlled trial (RCT) that accounted for the spectrum of pathology contributing to spinal stenosis, including pelvic incidence-lumbar lordosis (PI-LL) mismatch and mobile spondylolisthesis, could be conducted.MethodsAs part of the SpInOuT-F study, a pilot randomized trial was carried out across five NHS hospitals. Patients were randomized to either spinal decompression alone or spinal decompression plus instrumented fusion. Patient-reported outcome measures were collected at baseline and three months. The intended sample size was 60 patients.ResultsOf the 90 patients screened, 77 passed the initial screening criteria. A total of 27 patients had a PI-LL mismatch and 23 had a dynamic spondylolisthesis. Following secondary inclusion and exclusion criteria, 31 patients were eligible for the study. Six patients were randomized and one underwent surgery during the study period. Given the low number of patients recruited and randomized, it was not possible to assess completion rates, quality of life, imaging, or health economic outcomes as intended.ConclusionThis study provides a unique insight into the prevalence of dynamic spondylolisthesis and PI-LL mismatch in patients with symptomatic spinal stenosis, and demonstrates that there is a need for a definitive RCT which stratifies for these groups in order to inform surgical decision-making. Nonetheless a definitive study would need further refinement in design and implementation in order to be feasible.Cite this article: Bone Jt Open 2023;4(8):573–579.
Assessing the knowledge, attitudes, practices, and perspectives of stakeholders of the deworming program in rural Rwanda
Authors: Rwamwejo Fernand , Ndatinya Grace Iliza , Mkata Madalitso Ireen , Blauman Amy , Regnier Denis , Lackner Sarah Cruz 
Published: August 2023

Background
Worm infections are among the most prevalent neglected tropical diseases worldwide. Schistosomiasis and soil-transmitted helminths infections, most common worm infections affecting Rwandan school-aged children, are addressed by the national deworming program since 2014. To date, no published studies have assessed the knowledge, attitudes, and practices of the key implementers of the national deworming program conducted at village and school level in Rwanda. This study aimed to assess key stakeholders’ knowledge, attitudes, practices, and perspectives about the decentralized national deworming program.

Methods/Principal findings
We carried out a quantitative, cross-sectional study with complementary in-depth interviews in two districts of Rwanda in June 2021. From the 852 surveyed community health workers and teachers, 54.1% had a knowledge score considered good (≥80%). The mean knowledge score was 78.04%. From the multivariate analysis, lack of training was shown to increase the odds of having poor knowledge (OR 0.487, 95% CI: 0.328–0.722, p <0.001). The in-depths interviews revealed poor water access and hesitance from caregivers as perceived challenges to the success of the deworming program.

Conclusion
Our findings demonstrate the importance of training community health workers and schoolteachers on worm infections as they are the key implementers of the deworming program. This would enhance their capacity to provide health education and sensitization on misconceptions and misinformation towards deworming. Moreover, research is needed to assess the impact of poor access to water, sanitation and hygiene facilities on the prevalence of worm infections in Rwanda.
Control of distributed-parameter systems using normal forms: an introduction
Authors: Gehring Nicole , Irscheid Abdurrahman , Deutscher Joachim , Woittennek Frank , Rudolph Joachim 
Published: August 2023

Abstract
This paper gives an overview of the control of distributed-parameter systems using normal forms. Considering linear controllable PDE-ODE systems of hyperbolic type, two methods derive tracking controllers by mapping the system into a form that is advantageous for the control design, analogous to the finite-dimensional case. A flatness-based controller makes use of the hyperbolic controller canonical form that follows from a parametrization of the system’s solutions. A backstepping design exploits the strict-feedback form of the system to recursively stabilize and transform the subsystems.
HP1 induces ferroptosis of renal tubular epithelial cells through NRF2 pathway in diabetic nephropathy
Authors: Zhou Chuanqiang , Wu Min , Liu Gaolun , Zhou Li 
Published: August 2023

Abstract
The aim of this study was to investigate the role of ferroptosis in diabetic nephropathy (DN) and the mechanism of its regulatory genes. HK-2 cells were cultured with high glucose and mice were intraperitoneally injected with streptozotocin to establish DN models. GSE111154 was analyzed to identify the abnormal expression of genes associated with DN. Cell injury was evaluated through CCK-8 assay and 4′,6-diamidino-2-phenylindole/phenylindole double staining. The levels of iron, glutathione, malondialdehyde, urinary albumin, and urinary creatinine were determined by ELISA. Furthermore, western blot and RT-qPCR were used to detect protein and mRNA levels, respectively. Our data showed that heterochromatin protein 1 is an abnormally elevated gene related to DN and is further elevated by ferroptosis activators. Inhibition of HP1 significantly inhibited ferroptosis but promoted cell viability. In addition, nuclear factor erythroid2-related factor2 (NRF2) was decreased in DN cell model, but increased under the action of ferroptosis activators. NRF2 silencing reversed the protective effects of HP1 inhibition on HK-2 cells. Additionally, HP1 silencing also alleviated kidney damage in DN mice. Collectively, these findings suggest that inhibiting HP1 inhibits ferroptosis via NRF2 pathway, thereby protecting renal tubular epithelial cells from damage.
Using repeated antibody testing to minimize bias in estimates of prevalence and incidence of SARS-CoV-2 infection
Authors: Santacatterina Michele , Burke Brian , Gunaratne Mihili , Weintraub William S. , Espeland Mark A. , Correa Adolfo , Friedman-Klabanoff DeAnna , Gibbs Michael , Herrington David , Miller Kristen E. , Sanders John W. , Seals Austin L. , Uschner Diane , Wierzba Thomas F. , Mongraw-Chaffin Morgana 
Published: August 2023

Abstract

Objectives
The prevalence and incidence of SARS-CoV-2, the virus which causes COVID-19, at any given time remains controversial, and is an essential piece in understanding the dynamics of the epidemic. Cross-sectional studies and single time point testing approaches continue to struggle with appropriate adjustment methods for the high false positive rates in low prevalence settings or high false negative rates in high prevalence settings, and post-hoc adjustment at the group level does not fully address this issue for incidence even at the population level.

Methods
In this study, we use seroprevalence as an illustrative example of the benefits of using a case definition using a combined parallel and serial testing framework to confirm antibody-positive status. In a simulation study, we show that our proposed approach reduces bias and improves positive and negative predictive value across the range of prevalence compared with cross-sectional testing even with gold standard tests and post-hoc adjustment. Using data from the North Carolina COVID-19 Community Research Partnership, we applied the proposed case definition to the estimation of SARS-CoV-2 seroprevalence and incidence early in the pandemic.

Results
The proposed approach is not always feasible given the cost and time required to administer repeated tests; however, it reduces bias in both low and high prevalence settings and addresses misclassification at the individual level. This approach can be applied to almost all testing contexts and platforms.

Conclusions
This systematic approach offers better estimation of both prevalence and incidence, which is important to improve understanding and facilitate controlling the pandemic.
Crosstalk between cholesterol and PIP2 in the regulation of Kv7.2/Kv7.3 channels
Authors: Delgado-Ramírez Mayra , López-Serrano Ana Laura , Sánchez-Armass Sergio , Meza Ulises , Rodríguez-Menchaca Aldo A. 
Published: August 2023

Abstract
The activity of neuronal Kv7.2/Kv7.3 channels is critically dependent on PIP2 and finely modulated by cholesterol. Here, we report the crosstalk between cholesterol and PIP2 in the regulation of Kv7.2/Kv7.3 channels. Our results show that currents passing through Kv7.2/Kv7.3 channels in cholesterol-depleted cells, by acute application of methyl-β-cyclodextrin (MβCD), were less sensitive to PIP2 dephosphorylation strategies than those of control cells, suggesting that cholesterol depletion enhances the Kv7.2/Kv7.3–PIP2 interaction. In contrast, the sensitivity of Kv7.2/Kv7.3 channels to acute membrane cholesterol depletion by MβCD was not altered in mutant channels with different apparent affinities for PIP2.
The Late Palaeolithic in Toruń Basin in the light of the latest research in Brzoza, Site 50
Authors: Bielińska-Majewska Beata 
Published: August 2023

Abstract
This paper
The data from the article was presented by the author during 16th SKAM Lithic Workshop (“Fossil Directeur”. A Phenomenon over Time and Space), 21–23 October 2019, Nitra, Slovak Republic, presentation: The Late Palaeolithic in Toruń Basin in the light of the latest research in Brzoza, site 50 (poster session).
presents the preliminary findings related to the excavations in Brzoza site 50, commune Wielka Nieszawka, Kuyavian-Pomeranian Voivodeship (Poland). The Late Palaeolithic site complex in Brzoza – until the end of 1990s known as Toruń-Rudak – is located it Toruń Basin (Poland), in the grounds of a military shooting range on the left bank of Vistula south of the city. According to the Kuyavian-Pomeranian Voivodeship Monuments Conservator the whole complex was defined as one, site no. 50.
Rescue excavations in Brzoza in years 2015–2018 were conducted by the District Museum in Toruń. In total 276 m2 were excavated, resulting in documentation of over 11 000 flint products. The research was funded from the Kuyavian-Pomeranian Voivode budget via the Kuyavian-Pomeranian Voivodeship Monuments Conservator and the District Museum in Toruń. The research consisted of archaeological exploration at the remains of the dune embankment, to locate and document undisturbed (in situ) cultural features (flint concentrations). In order to capture the stratigraphic situation in the vicinity of the planned research excavations and to locate the cultural layer with the flint materials linked to the Late Palaeolithic surveys were conducted by means of drillings. The following specialist examinations and consultations were carried out: geological and geomorphological documentation; analyzes of the geographical environment and pedostratigraphy of the research area; from selected profiles soil samples were taken for TL and OSL method analyses. Against the background of other well-known sites with tanged points in northern Poland, the area under study stands out both in terms of the number of flint products obtained and the documented flint concentrations. It must be emphasized that the context of new flint concentrations discovered in Brzoza in the years 2015–2018 is different than that of earlier investigations. Flint products were discovered in a preserved planigraphic and stratigraphic layout; not on a secondary deposit, as was the case, among others in the 1970s. New concentrations discovered in 2015–2018 are related to the Late Palaeolithic technocomplex with tanged points. Amongst flint tools there are elements typologically characteristic to Ahrensburg and Swiderian culture, and individual finds that can be associated with Bromme assemblages. At the present stage of research the acquired flint materials can be linked to the Late Palaeolithic communities present in the area presumably in the younger Dryas. Brzoza site complex occupies an important place in the research of the Late Palaeolithic of northern Poland.
Color match evaluation using instrumental method for three single-shade resin composites before and after in-office bleaching
Authors: Cilingir Aylin , Kariper Engin 
Published: August 2023

Abstract
The aim of this study is to evaluate the effect of an office bleaching agent on the color of various single-shade resin composites. Three single-shade resin composites were tested in this study. Thirty disk-shaped specimens were prepared with a diameter of 10 mm and a height of 1 mm, and they were divided into three groups (n = 10). After color measurements, 40% hydrogen peroxide containing bleaching agent gel was applied to all the specimens. Baseline and final color measurements were performed using a clinical spectrophotometer. Statistical analyses were performed. All bleached specimens had clinically incomprehensible color changes (ΔE < 3.3). Comparisons for single-shade composites revealed no statistically significant color difference between groups. With the limitation of this study in mind, color changes in single-shade resin-composites after office bleaching were found to be clinically acceptable. It may be appropriate to use single-shade composites that shorten the in-chair clinical time by facilitating shade selection.
Revisiting PIMRS and Curriculum Instruction Management: Evaluation of Principalship in Banda Aceh
Authors: Nurviani Rahima , Abdullah Mohamad Ridhuan 
Published: August 2023

This research explored how the principals in Banda Aceh XYZ Schools manage the curriculum and instruction and its relatedness to Principal Instructional Management Rating Scale (PIMRS) (Halinger, 1985). This research has 3 research questions and to answer them, a cross-sectional survey, adapted from PIMRS was used and administered to 186 teachers from local schools there. Research findings indicate that principals of Banda Aceh XYZ school played moderate roles (µ =3.78) in managing curriculum and instruction, and no statistical difference between male and female teachers’ perceptions of principals’ roles in managing curriculum and instruction. The results pointed to the importance of having workshops and policy discussions to improve teaching and parallel understanding of curriculum and instruction for teachers and administrators.
Abstrak
Penelitian ini mengupas bagaimana kepala sekolah di Sekolah-Sekolah XYZ di Banda Aceh mengatur kurikulum dan pengajaran serta keterkaitannya dengan Principal Instructional Management Rating Scale (PIMRS) (Hallinger, 1985). Penelitian ini menjawab tiga pertanyaan penelitian dengan mengadaptasi PIMRS dalam survei terhadap 186 orang guru di sekolah lokal. Hasil penelitian mengidentifikasikan bahwa kepala-kepala sekolah XYZ di Banda Aceh berperan moderat (sedang) (µ =3.78) dalam mengatur kurikulum dan pengajaran, dan tidak ditemukan perbedaan signifikan antara pendapat guru laki-laki dan perempuan dalam hal peran kepala sekolah mengatur kurikulum dan pengajaran. Selain itu hasil penelitian juga menunjukkan pentingnya pelatihan dan pembahasan kebijakan untuk meningkatkan pengajaran dan pemahaman menyeluruh terhadap kurikulum dan pengajaran bagi guru dan admistrator sekolah.
The Effectiveness of Google Classroom in the Flipped Class-room Model for English Subjects in Vocational School
Authors: Larasati Devi , Haryono Haryono 
Published: August 2023

The purpose of this study is to determine the effectiveness of Google classroom as an e-learning-based learning medium in the Flipped Classroom model to improve student learning outcomes in English subjects at Ibu Kartini Vocational High School, Semarang City. The research method used in this study was quantitative approach, a quasi-experimental design with a non-equivalent control group design model. The sample selection of this research is simple random sampling technique. The tool used to collect data in this study was a test with 50 multiple choice questions. The data analysis technique used is the independent sample t-test and the N-gain score test. The results of the hypothesis test showed that there was a significant difference in learning outcomes between the experimental class and the control class. It means that the use of Google classroom as an e-learning-based learning medium in the Flipped Classroom model proved effective in improving students' learning outcomes.
Abstrak
Penelitian ini bertujuan mengetahui sejauh mana keefektifan Google classroom sebagai media pembelajaran berbasis e-learning dalam model Flipped Classroom untuk meningkatkan hasil belajar siswa pada mata pelajaran bahasa inggris di SMK Ibu Kartini kota Semarang. Penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian eksperimen. Desain penelitian ini menggunakan pola quasi experimental design dengan model non-equivalent control group design. Pemilihan sampel penelitian ini dengan teknik simple random sampling. Alat yang digunakan untuk mengumpulkan data pada penelitian ini adalah Tes dengan soal pilihan ganda sebanyak 50 butir soal. Teknik analisis data yang digunakan yaitu uji independent sampel t-test dan uji N-gain score. Hasil uji hipotesis menunjukkan adanya perbedaan yang signifikan hasil belajar antara kelas eksperimen dan kelas kontrol. Dengan demikian dapat disimpulkan bahwa pemanfaatan Google classroom sebagai media pembelajaran berbasis e-learning dalam model Flipped Classroom terbukti efektif meningkatkan hasil belajar siswa pada mata pelajaran bahasa Inggris.