bluuebunny/crossref_metadata_2025_split huggingface dataset:
5-year outcomes of pulmonary embolism patients according to symptoms at 6-month: the QOLAPE study
Authors: Benezech L , Laroche T , Lointier E , Beneyto M , Lapebie F X , Biendel C , Lairez O , Moine T , Martin R , Elbaz M , Bura-Riviere A , Delmas C 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public hospital(s). Main funding source(s): CHU Toulouse Rangueil

Background
Venous thromboembolic disease is a common cardiovascular disease, but long-term data on patient survival according to mid-term symptoms are scarce.

Objective
To describe outcomes (mortality and functional status) of pulmonary embolism (PE) 5 years after a first inaugural symptomatic episode of acute PE according to symptoms persistence at 6-months.

Methods
137 patients with acute symptomatic PE were consecutively recruited at a French University Hospital from 2015 to 2017. Clinical characteristics were compared at 5-years between patients with persistent respiratory symptoms and asymptomatic patients at 6-month. Telephone collection of vital status, recurrence of VTE, NYHA score, current treatment, bleeding events as well as follow-up provided by a specialist were carried out in March 2022 on 105 patients (11% were lost of follow up).

Results
Patients were predominantly male (n=63, 57.5%) 60.2 yo. PE was initially classified at low, intermediate low, intermediate high and high risk respectively in 42.8, 25.7, 30.5 and 1%. 60 patients (57%) were symptomatics at 6 months. At 5 years, survival was 87.1% with a 17.7% recurrence rate regardless of initial PE presentation and severity, and 50% of patients remain symptomatic. Age, hypertension, diabetes, renal failure, obesity and the existence of a psychiatric pathology are associated with a higher mortality at 5 years. The survival and recurrence of MTVE at 5 years are similar between symptomatic or asymptomatic status at 6 months but symptomatic patients at 6 months are twice as many symptomatic at 5 years than asymptomatic patients at 6 months.

Conclusion
After an inaugural acute symptomatic PE is 5-year survival was 87%. Age, obesity, diabetes, renal failure, hypertension and the existence of an underlying psychiatric pathology are associated with a poorer prognosis at 5 years. The persistence of symptoms at 6 months of PE was not correlated with survival or recurrence of VTE at 5 years but at the persistence of symptoms at 5 years.
Remote vessels vs culprit-only angioplasty in ST-segment elevation myocardial infarction: reinfarction and all-cause mortality
Authors: Sa Couto D , Alexandre A , Faria J , Luz A , Campinas A , Frias A , Santos R , Brochado B , Silveira J , Torres S 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background and purpose
In ST-segment elevation myocardial infarction (STEMI) patients with multivessel coronary artery disease (MVCAD), remote-vessel percutaneous coronary intervention (PCI) has been associated with a reduction in the incidence of reinfarction when compared to a culprit-only revascularization strategy. Overall effects on long-term all-cause mortality are still unclear.

Methods
Between 2008 and 2013, a total of 584 consecutive patients were admitted with STEMI. 535 survived to discharge, from which 302 (56,5%) had MVCAD and were included in the analysis. We stratified the patients according to the revascularization strategy in two groups: culprit-lesion-only PCI and PCI of non-culprit vessels with angiographic significant stenosis. Patients were followed for 8 years. The primary endpoints were reinfarction in any vessel and all-cause death. Secondary endpoints included target vessel failure (TVF) (any repeat revascularization in the index culprit vessel), heart failure (HF) hospitalization and stroke.

Results
Of the 302 cases, 217 (74.2%) were men and the median age was 63 years. 150 (49.7%) had 2-vessel, 152 (50.3%) had 3-vessel disease and 104 (34.4%) underwent non-culprit vessel PCI. The mean follow-up time was 6.95 (± 2.29) years. Overall, the culprit-lesion-only group was older (median: 66 vs 59.5 years; p &lt; 0.001) and had a lower proportion of smokers (41.9% vs 59.6%; p = 0.003). There were no significant differences between the groups’ other main comorbidities. The culprit-lesion-only group had a shorter hospital stay (median: 7.0 vs 7.5; p = 0.013), despite presenting at higher Killip class (24.4% vs 10.6% in Killip II-IV; p = 0.004). Regarding index PCI, no-reflow phenomenon was more common in the culprit-lesion-only group (7.1% vs 1.0%; p = 0.020), where the use of drug-eluted stents was more prevalent in the remote-vessel PCI group (69.2% vs 47.0%; p = 0.001). There was a higher risk of reinfarction (Adjusted hazard ratio (HR) 2.46; 95% CI [1.12 – 5.38]; p = 0.008) and TVF (Adjusted HR 2.37; 95% CI [1.02 – 5.48]; p = 0.044) in the culprit-lesion-only PCI group after relevant variable adjustment, with no significant differences in all-cause mortality. There were no significant differences in any of the remaining secondary outcomes.

Conclusions
Randomized trials and successive metanalysis have demonstrated benefit in complete revascularization after STEMI regarding the incidence of reinfarction and cardiovascular death. However, the long term impact on all-cause death is still unclear. This study corroborates the main findings in the literature, while suggesting lack of effect on overall mortality on a long-term follow-up.
Early outcome of on- versus off-hours admission in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) during COVID-19 pandemic
Authors: Gjana A , Skenderi A , Kristo A , Pavli E , Tafaj E , Simoni L , Kresto L , Seiti J , Duka A , Katana E , Kastrati A , Dibra A 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Most of studies have found no relevant impact of admission time on STEMI outcome among patients treated with primary PCI. Whether this observation has been affected by coronavirus disease (COVID-19) pandemic, in particular during the curfew application, has not been evaluated.

Purpose
To study the influence of admission time on the outcome of STEMI patients treated with primary PCI during COVID-19 pandemic in a large volume University Hospital Center, the only center capable of primary PCI serving a large area without an established STEMI network

Methods
Characteristics and outcomes of 308 consecutive STEMI patients admitted to our center between May 28 to December 2020, were collected. On-hours were defined as admission from Monday through Friday from 8:00 to 15:30 and off-hours admission from 15:30 to 8:00, weekends and non-working holidays. Clinical characteristics, key time delays and in-hospital and 3-month mortality were evaluated.

Results
75 (24%) patients were admitted on-hours and 233 (76%) patients were admitted off-hours. There were no differences between groups regarding baseline clinical characteristics, laboratory data and STEMI clinical presentation. Median time from pain onset to coronary care unit admission was 4.0 hours in the on-hours group versus 6.0 hours in the off-hours group (p=0.11). Median time from coronary care unit to cathlab was 1.5 hours in the on-hours group versus 1.0 hour in the off-hour group (p=0.14). There was no difference between on-hours versus off- groups regarding in-hospital mortality (4% versus 6%, p=0.77) and 3-month mortality (10% versus 10%, p=0.76), as well as recurrent infarction (p=0.56) and stent thrombosis (p=0.64).

Conclusion(s)
Despite the lack of an organized STEMI network, patients admitted to a large-volume primary PCI tertiary center during COVID-19 pandemic, had similar outcome regardless their admission during on-hours or off-hours. Althgouh the specific impact of curfew on out of hospital time delays could not be assessed, it did not appear to influence patient outcomes.
The prognostic impacts of frailty status on clinical and patient-related outcomes in patients undergoing coronary artery or valvular surgeries/procedures: a systematic review and meta-analysis
Authors: Wong C W Y , Yu D S F , Li P W C , Chan B S Y 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Frailty is emerging as an important prognostic indicator for patients undergoing cardiac surgeries or procedures.

Purposes
We sought to evaluate the prognostic and differential impacts of frailty on patients undergoing coronary artery or valvular surgical procedures of different levels of invasiveness, as well as to explore the differential predictability of various frailty measurement models.

Methods
Nine databases were searched for prospective cohort studies that have adopted validated measure(s) of frailty and reported clinical, healthcare service utilisation, or patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures. Meta-analysis was conducted using random-effects model.

Results
Sixty-two articles were included (N = 16,679). Frailty significantly predicted mortality (short-term [≤ 30 days]: odds ratio [OR]: 2.33, 95% confidence interval [CI]: 1.28–4.26; mid-term [1 year]: OR: 3.93, 95% CI: 2.65–5.83; long-term [&gt;1 year]: HR: 2.23, 95% CI: 1.60–3.11), postoperative complications (ORs: 2.54–3.57), discharge to care facilities (OR: 5.52, 95% CI: 3.84–7.94), hospital readmissions (OR: 2.00, 95% CI: 1.15–3.50), and reduced health-related quality of life (HRQoL; SMD: −0.74, 95% CI: −1.30 to −0.18) (Figure 1 and 2). Subgroup analyses showed that frailty exerted a greater impact on short-term mortality in patients undergoing open-heart surgeries than those receiving transcatheter procedures (Figure 1A), but no significant difference was observed for mid- and long-term mortality between these two groups of patients (Figure 1B and C). Multidimensional and physical-aspect-focused frailty measurements equally predicted mortality and complications, but multidimensional measurements were more predictive of hospital readmissions than physical-aspect-focused measurements (Figure 2B).

Conclusion
Frailty was predictive of postoperative mortality, complications, increased healthcare service utilisation, and reduced HRQoL. The impact of frailty on short-term mortality was more prominent in patients undergoing open-heart surgeries than those receiving transcatheter procedures. Multidimensional measures of frailty enhanced prognostic risk estimation, especially for hospital readmissions, demonstrating a need to incorporate a formal frailty assessment into routine preoperative risk evaluation to inform therapeutic decision-making.
Cardiogenic shock due to probable SARS-CoV-2 myocarditis—a case report
Authors: Klasen Martiene , Smit Marije , Renes Maurits , Damman Kevin , Droogh Joep M 
Published: May 2023

Abstract

Background
Since the start of the COVID-19 pandemic, many case reports have been presented describing different cardiac symptoms due to the SARS-CoV-2 infection. However, severe cardiac failure due to COVID-19 seems to be rare.

Case summary
A 30-year-old woman presented with COVID-19 and cardiogenic shock due to a lymphocytic myocarditis. Since she deteriorated under treatment with inotropes, she was referred to our centre, and veno-arterial extracorporeal life support was started. Subsequently, the aortic valve only opened sporadically, and spontaneous contrast appeared in the left ventricle (LV), pointing towards difficulties with unloading LV. Therefore, an Impella for venting the LV was implanted. After 6 days of mechanical circulatory support, her heart function recovered. All support could be weaned, and 2 months later, she had made a full recovery.

Discussion
We presented a patient with severe cardiogenic shock due to an acute virus-negative lymphocytic myocarditis associated with a SARS-CoV-2 infection. Since the precise aetiology of SARS-CoV-2-related myocarditis remains to be elucidated and no virus could be detected in the heart, a causal relationship remains speculative.
Micro-evolutionary response of spring migration timing in a wild seabird
Authors: Moiron Maria , Teplitsky Céline , Haest Birgen , Charmantier Anne , Bouwhuis Sandra 
Published: May 2023

Abstract
In the context of rapid climate change, phenological advance is a key adaptation for which evidence is accumulating across taxa. Among vertebrates, phenotypic plasticity is known to underlie most of this phenological change, while evidence for micro-evolution is very limited and challenging to obtain. In this study, we quantified phenotypic and genetic trends in timing of spring migration using 8,032 dates of arrival at the breeding grounds obtained from observations on 1,715 individual common terns (Sterna hirundo) monitored across 27 years, and tested whether these trends were consistent with predictions of a micro-evolutionary response to selection. We observed a strong phenotypic advance of 9.3 days in arrival date, of which c. 5% was accounted for by an advance in breeding values. The Breeder’s equation and Robertson’s Secondary Theorem of Selection predicted qualitatively similar evolutionary responses to selection, and these theoretical predictions were largely consistent with our estimated genetic pattern. Overall, our study provides rare evidence for micro-evolution underlying (part of) an adaptive response to climate change in the wild, and illustrates how a combination of adaptive micro-evolution and phenotypic plasticity facilitated a shift towards earlier spring migration in this free-living population of common terns.
Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease
Authors: Amarasekera Sumudu S C , Hock Daniella H , Lake Nicole J , Calvo Sarah E , Grønborg Sabine W , Krzesinski Emma I , Amor David J , Fahey Michael C , Simons Cas , Wibrand Flemming , Mootha Vamsi K , Lek Monkol , Lunke Sebastian , Stark Zornitza , Østergaard Elsebet , Christodoulou John , Thorburn David R , Stroud David A , Compton Alison G 
Published: May 2023

Abstract
MRPL39 encodes one of 52 proteins comprising the large subunit of the mitochondrial ribosome (mitoribosome). In conjunction with 30 proteins in the small subunit, the mitoribosome synthesizes the 13 subunits of the mitochondrial oxidative phosphorylation (OXPHOS) system encoded by mitochondrial Deoxyribonucleic acid (DNA). We used multi-omics and gene matching to identify three unrelated individuals with biallelic variants in MRPL39 presenting with multisystem diseases with severity ranging from lethal, infantile-onset (Leigh syndrome spectrum) to milder with survival into adulthood. Clinical exome sequencing of known disease genes failed to diagnose these patients; however quantitative proteomics identified a specific decrease in the abundance of large but not small mitoribosomal subunits in fibroblasts from the two patients with severe phenotype. Re-analysis of exome sequencing led to the identification of candidate single heterozygous variants in mitoribosomal genes MRPL39 (both patients) and MRPL15. Genome sequencing identified a shared deep intronic MRPL39 variant predicted to generate a cryptic exon, with transcriptomics and targeted studies providing further functional evidence for causation. The patient with the milder disease was homozygous for a missense variant identified through trio exome sequencing. Our study highlights the utility of quantitative proteomics in detecting protein signatures and in characterizing gene-disease associations in exome-unsolved patients. We describe Relative Complex Abundance analysis of proteomics data, a sensitive method that can identify defects in OXPHOS disorders to a similar or greater sensitivity to the traditional enzymology. Relative Complex Abundance has potential utility for functional validation or prioritization in many hundreds of inherited rare diseases where protein complex assembly is disrupted.
Traditional values, family, homeschooling: The role of Russia and the Russian Orthodox Church in transnational moral conservative networks and their efforts at reshaping human rights
Authors: Stoeckl Kristina 
Published: May 2023

Abstract
In the last two decades, Russian state actors and the Russian Orthodox Church have come to play an increasingly important role in the undermining of established understandings of international human rights law by reinterpreting its aims and repurposing its institutions, in particular the Universal Declaration of Human Rights, the United Nations Human Rights Council, and the European Court of Human Rights. Russian state and church leaders have appropriated and coopted the language of human rights in order to advance an illiberal and nationalist agenda that undercuts democratic values and targets particular groups and their rights and freedoms—most notably liberal civil society, political opposition, and the LGBTIQ+ community. Written from the angle of a constructivist sociology of human rights, this article brings together three case studies of Russian rights appropriation around the topics of traditional values, family, and homeschooling and draws six lessons on the (mis)appropriation of human rights for illiberal purposes. The analysis of Russia’s rights appropriation sheds light on the background and build-up for current events in Russia’s war against Ukraine.
Elites’ (De)legitimation Practices toward International Organizations
Authors: Uhlin Anders , Verhaegen Soetkin 
Published: May 2023

AbstractResearch on legitimacy of international organizations (IOs) has often focused on discursive self-legitimation by IOs. This article explores the role of other (de)legitimizing actors. Distinguishing between elites of different political and societal sectors, we use unique data from a survey of 860 political and societal elites in Brazil, Germany, the Philippines, Russia, South Africa, the United States, and a global elite group, to perform the first systematic analysis of elites’ (de)legitimation practices toward IOs. We analyze behavioral as well as discursive practices that may boost or challenge citizens’ legitimacy beliefs toward IOs, and describe how elites’ repertoires of (de)legitimation practices vary across IOs, elite sectors, and geographical locations. Explanatory analyses test whether the use of legitimation and delegitimation practices can be explained by characteristics of the interviewed elites. We find that most elites engage in (de)legitimation of IOs. Legitimation is more common than delegitimation. While discursive practices are more frequently used, behavioral practices are more widespread than acknowledged in previous research. Societal elites are more frequent (de)legitimizers of IOs than assumed in more state-centric accounts of global governance. Attitudes of elite individuals (confidence in the IO and ideological position) partly explain engagement in (de)legitimation. By providing the general pattern of elite (de)legitimation of IOs, the article sets the scene for more detailed case studies of diverse (de)legitimation practices toward specific IOs.
Proof-carrying parameters in certified symbolic execution
Authors: Arusoaie Andrei , Lucanu Dorel 
Published: May 2023

Abstract
Complex frameworks for defining programming languages aim to generate various tools (e.g. interpreters, symbolic execution engines, deductive verifiers, etc.) using only the formal definition of a language. When used at an industrial scale, these tools are constantly updated, and at the same time, it is required to be trustworthy. Ensuring the correctness of such a framework is practically impossible. A solution is to generate proof objects as correctness artefacts that can be checked by an external trusted checker. A logic suitable for developing such frameworks is matching logic. K framework is a canonical example having matching logic-based foundation. Since the (symbolic) configurations of the programs are represented by matching logic patterns, the algorithms computing the dynamics of these configurations can be seen as pattern transformers and a proof object should be generated for the relationship between these patterns. In this paper, we show that conjunctions and disjunctions of patterns, produced by semantics or analysis rules, can be safely normalized using unification and antiunification algorithms. We also provide a prototype implementation of our proof object generation technique and a checker for certifying the generated objects.
Clinical results of proton beam radiotherapy for inoperable stage III non-small cell lung cancer: a Japanese national registry study
Authors: Tatebe Hitoshi , Harada Hideyuki , Mori Keita , Iwata Hiromitsu , Akimoto Tetsuo , Murakami Masao , Waki Takahiro , Ogino Takashi , Nakamura Masatoshi , Taguchi Hiroshi , Nakayama Haruhiko , Satouchi Miyako , Aoyama Hidefumi 
Published: May 2023

Abstract
This study presents the first data of a Japanese nationwide multi-institutional cohort and compares them with the findings of systematic literature reviews on radiation therapies and inoperable stage III non-small cell lung cancer (NSCLC) conducted by the Lung Cancer Working Group in the Particle Beam Therapy (PBT) Committee and Subcommittee at Japanese Society for Radiation Oncology. The Lung Cancer Working Group extracted eight reports and compared their data with those of the PBT registry from May 2016 to June 2018. All the analyzed 75 patients aged ≤80 years underwent proton therapy (PT) with concurrent chemotherapy for inoperable stage III NSCLC. The median follow-up period of the surviving patients was 39.5 (range, 1.6–55.6) months. The 2- and 3-year overall survival (OS) and progression-free survival rates were 73.6%/64.7% and 28.9%/25.1%, respectively. During the follow-up period, six patients (8.0%) had adverse events of Grade ≥ 3, excluding abnormal laboratory values. These included esophagitis in four patients, dermatitis in one and pneumonitis in one. Adverse events of Grade ≥ 4 were not observed. The results of these PBT registry data in patients with inoperable stage III NSCLC suggest that the OS rate was at least equivalent to that of radiation therapy using X-rays and that the incidence of severe radiation pneumonitis was low. PT may be an effective treatment to reduce toxicities of healthy tissues, including the lungs and heart, in patients with inoperable stage III NSCLC.
First case of nickel-metal hydride battery ingestion in child
Authors: Hui Martha Lok-Yung , Ng Justin Ho-Yin 
Published: May 2023

Abstract
We describe a case of a 12-year-old female with a past history of autism spectrum disorder who presented to the emergency department of a rural hospital in Australia after ingesting two nickel-metal hydride (NiMH) batteries at home. Hitherto, no literature has described any gastrointestinal complications related to NiMH battery ingestion. This paper aims to provide insight into the management of NiMH battery ingestion and to increase the awareness of the need for prompt management to prevent further damage to the gastrointestinal tract.
Multiloculated omental cystic tumor hiding an angioleiomyoma: case report of a rare and atypical presentation and literature review
Authors: Giambusso Mauro , Caprino Paola , Sacchetti Franco , Potenza Angelo Eugenio , Pastena Dario , Sofo Luigi 
Published: May 2023

Abstract
Angioleiomyoma is a rare benign tumor arising from vascular smooth muscle and generally located in the subcutaneous tissue of the extremities. We reported a rare case of an intra-abdominal localization originating from the small omentum in which progressive growth detected on radiological follow-up indicated surgical excision. Histology documented a cavernous angioleiomuscular tumor with uncertain potential for malignancy. Although angioleiomyoma is described as a benign tumor, the uncertain behavior for malignancy of this case could have led to neoplastic degeneration. Early diagnosis followed by surgical excision of the neoplasia is crucial.