bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D and lactoferrin attenuate stress‐induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR–STAT3 signaling and modulating autophagy
Authors: Abdelmalak Marian F. L. , Abdelrahim Dina S. , George Michael Tari M. A. , Abdel‐Maksoud Omnia M. , Labib Jolly M. W. 
Published: January 2023

AbstractIrritable bowel syndrome (IBS) is a global gastrointestinal disorder closely related to psychological stress exposure and local colonic inflammation. Herein, we investigated the effect of wrap‐restraint stress (WRS) on rat behavior, on adenosine monophosphate‐activated protein kinase–mammalian/mechanistic target of rapamycin–signal transducer and activator of transcription 3 (AMPK–mTOR–STAT3) signaling, and autophagy in colonic mucosa. The impact of chronic administration of vitamin D3 and lactoferrin was compared. Twenty‐four male Wistar rats were randomly divided into four groups. Chronic WRS protocol was applied as a rodent model of IBS. Group I: naïve animals, Group II: WRS animals, Group III: WRS‐exposed and treated with vitamin D3 (500 IU/kg/day), and Group IV: WRS‐exposed and treated with lactoferrin (300 mg/kg/day). In this study, we found that chronic administration of each of vitamin D3 and lactoferrin resulted in a significant increase in social interaction test, interleukin‐10, AMPK, optical density of LC3B, goblet cell count and marked decrease in serum cortisol level, STAT3, inflammatory cell count, and optical density of mTOR in comparison to the WRS rats. Our findings suggest that both vitamin D3 and Lactoferrin could augment colonic autophagy through enhanced AMPK expression and inhibition of mTOR–STAT3 signaling, which offers practical insights into their clinical use in the prevention and therapy of IBS. However, lactoferrin intake as a nutritional supplement could be more helpful for stress‐induced colitis treatment than vitamin D3.
Pyrene‐Based Self‐Assembling Peptide for Ratiometric Detection of Heparin
Authors: Shao Liang , Yu Hongwen , Song Jiaqi , Liu Shichang , Li Guanying 
Published: January 2023

AbstractHeparin is a commonly used anticoagulant in clinical practice; however, excessive heparin can cause serious adverse reactions. Convenient and accurate detection of heparin levels is thus very important. In this research, a pyrene‐based self‐assembling fluorescent peptide PyFFRRR was designed for simple, selective, and efficient heparin detection. The guanidine groups in the arginine residues of PyFFRRR bind tightly with heparin, which is highly sulfated, through electrostatic interactions. Charge neutralization facilitated the self‐assembly of PyFFRRR, resulting in its spectral response changing from deep blue monomer fluorescence to green excimer fluorescence. PyFFRRR exhibited excellent sensitivity and selectivity for ratiometric detection of heparin. The binding mechanism was investigated by using spectral and simulation tools, and structural observation. Finally, PyFFRRR was employed in human serum samples for ratiometric detection of heparin.
Palestinian Youth Engagement with Online Political Contents Shared by Citizen Journalists—The Case of Save Sheikh Jarrah
Authors: Yousef Rola Khalid 
Published: January 2023

AbstractInitial research on online political activism reveals that new information and communication technologies (ICTs) have increasingly become a growing and supportive space for political participation, which has influenced the conception of political activism. Furthermore, ICTs have become a facilitator for the formation of online political networks and communities. The shocking images of young children killed in the latest genocidal onslaught by Israel against Gaza in 2021 and the clashes that broke out in Sheikh Jarrah and Al Aqsa Mosque dominated the global news and online media platforms. Online political activists, such as Muna El Kurd, who represents the phenomenon of “Citizen Journalism” in Palestine, took to the internet and social media channels to ardently express their discontentment about the unhumanitarian actions and human rights violations being committed. This article aims to map out the Palestinian youth engagement with online political content disseminated by Muna El Kurd' Instagram and Twitter accounts, by employing an empirical approach using a quantitative research method to collect primary data while relying on the literature review to discuss in‐depth online activism and the concept of Citizen Journalism in the Middle East. An online survey, in Arabic language, was conducted following the simple random sampling technique, targeting one hundred college‐educated and technologically advanced Palestinian youth respondents (18–29 years old). The data collected was used to examine and address specific research questions related to what information sources the youth use to acquire political information and to what extent they rely on social media platforms belonging to citizen journalists. The study concluded that Palestinian youth participate in many online activities and rely on social media platforms for information; their interests and knowledge of politics are growing; the surveyed youth in Palestine are highly interested in political matters and are moderate participants in online political discussions.
Spin Crossover Behavior of FeII Complexes Bridged by Thiophene‐Functionalized Triazole Ligands with Different Sizes and Rigidities
Authors: Yuan Hao , Wo Jian‐Gang , Yue Zheng , Yu Hua‐Bing , Wang Wen‐Ping , Wang Di 
Published: January 2023

AbstractFour thiophene functionalized triazole ligands (L1=4‐(thenyl)‐1,2,4‐triazole, L2=4‐(thiophene ethyl)‐1,2,4‐triazole, L3=N‐Thiophenylidene‐4H‐1,2,4‐triazole‐4‐amine, and L4=(4‐[(E)‐2‐(5‐sulfothiophene)vinyl]‐1,2,4‐triazole) were synthesized. These ligands have different lengths and rigidities, while ligand L4 has a sulfonic acid group that can form a hydrogen bond. Five 1D FeII chain complexes were synthesized: [Fe(L1)3](X)2 ⋅ nH2O [X=BF4−, n=1.5 (C1); X=ClO4−, n=1 (C2)], [Fe(L2)3](BF4)2 ⋅ 1.5H2O (C3); [Fe(L3)3](X)2 ⋅ nH2O [X=BF4−, n=2 (C4); X=ClO4−, n=2.5 (C5)]. The results of temperature‐dependent magnetic susceptibility reveal that complexes C1, C2, and C3 experienced the transition between two spin states. And C4 and C5 maintain high spin states at all temperature ranges. Binuclear complex [Fe2(L3)5(SCN)4] (C6) and mononuclear material [Fe(L4)2(H2O)4] ⋅ 2H2O (C7), these two zero‐dimensional molecules were also synthesized. They all display weak antiferromagnetic exchange coupling and a high spin state in the whole process.
Microbial community structure and biogenic amines content variations in chilled chicken during storage
Authors: Min Hong , An Fengqiu , Wei Ting , Wang Song , Ma Pengfei , Dai Yong 
Published: January 2023

AbstractThe aim of this study was to investigate the sensory indicators, biogenic amine contents, and bacterial community structure and diversity of chilled chicken stored at 4°C under aerobic conditions. Bacterial diversity and dominant bacteria were analyzed using high‐throughput sequencing technique (HTS). The relationship between biogenic amine contents and microbial community structure was studied. The results showed that contents of putrescine and cadaverine increased significantly with storage time. Proteobacteria was absolutely dominant flora at the phylum level. The predominant spoilage bacteria found in chicken thighs were Pseudomonas, Acinetobacter, Aeromonas, Shewanella, and Yersinia, and the difference with chicken breasts was related to the presence of Myroides and absence of Yersinia. Myroides, Yersinia, and Shewanella were reported for the first time as an important contributor to the spoilage‐related microflora. Bacterial diversity and richness indices showed fluctuating and decreasing trend with storage time. The redundancy analysis showed that the relative abundance of Pseudomonas, Yersinia, and Janthinobacterium was positively related to the contents of putrescine, cadaverine, and tyramine, while Shewanella and Aeromonas showed positive relationship with putrescine content. Furthermore, positive relationship of Myroides and Desulfovibrio with the contents of cadaverine and tyramine was proposed for the first time. The key findings of this study can provide experimental data for food safety monitoring during refrigerated storage and preservation for poultry meat products.
Pharmacotherapeutic values of berberine: A Chinese herbal medicine for the human cancer management
Authors: Devarajan Nalini , Nathan Jhansi , Mathangi Ramalingam , Mahendra Jaideep , Ganesan Senthil Kumar 
Published: January 2023

AbstractBerberine (BBR), a traditional Chinese phytomedicine extracted from various parts of Berberis plants, is an isoquinoline alkaloid used for centuries to treat diabetes, hypercholesterolemia, hypertension, and so forth. It has recently received immense attention worldwide to treat cancer due to its potent pro‐apoptotic, antiproliferative, and anti‐inflammatory properties. BBR efficiently induces tumor apoptosis, replicative quiescence and abrogates cell proliferation, epithelial–mesenchymal transition, tumor neovascularization, and metastasis by modulating diverse molecular and cell signaling pathways. Furthermore, BBR could also reverse drug resistance, make tumor cells sensitive to current cancer treatment and significantly minimize the harmful side effects of cytotoxic therapies. This review comprehensively analyzed the pharmacological effects of BBR against the development, growth, progression, metastasis, and therapy resistance in wide varieties of cancer. Also, it critically discusses the significant limitations behind the development of BBR into pharmaceuticals to treat cancer and the future research directions to overcome these limitations.
Diagnostic Value of Contrast‐Enhanced Ultrasound Features for WHO/ISUP Grading in Renal Cell Carcinoma
Authors: Huang Xiao , Nie Fang , Zhu Ju , Liu Luping , Wang Nan 
Published: January 2023

ObjectivesBy analyzing the differences of contrast‐enhanced ultrasound (CEUS) features between low‐ and high‐grade of WHO/ISUP grading, to explore the diagnostic value of CEUS in evaluating the prognosis of renal cell carcinoma (RCC).MethodsThe qualitative and quantitative features of CEUS in 69 patients with RCC confirmed by surgical pathology in the Lanzhou University Second Hospital from March to October 2021 were retrospectively analyzed. Patients were categorized into two groups: low‐grade group (n = 22) and high‐grade group (n = 47), with surgical pathology as reference standard. The diagnostic performance of statistically significant CEUS features was evaluated by receiver operating characteristic (ROC) curves.ResultsThere were statistically significant differences in enhancement degree (P = .032) and quantitative features such as slopelesion (P = .034), the differences between lesion and cortex in arrive time (∆AT = ATlesion − ATcortex, P = .013), peak intensity(∆PI = [PIlesion − PIcortex]/PIcortex, P = .003), area under the curve (∆Area = Arealesion − Areacortex, P = .008) in two groups, and the sensitivity was 70.2% and specificity was 71.4% of ∆PI, which has a high diagnostic performance in the differentiation of low‐grade group from high‐grade group (P = .005).ConclusionsCEUS features such as ∆PI, may help differentiate low‐grade RCC from high‐grade RCC. CEUS has a promising application prospect in preoperative evaluation of the prognosis of RCC.
Dermatomyositis following COVID‐19 vaccination: Temporal or causal association?
Authors: Ouni Nour E. I. , Lahouel Maha , Ben Salah Nesrine , Mokni Sana , Sriha Badreddine , Belajouza Colandane , Denguesli Mohamed 
Published: January 2023

AbstractSeveral cutaneous complications have been reported with COVID‐19 vaccines. Most of them are benign and consist mainly of delayed local reactions, urticaria, and morbilliform eruptions. Dermatomyositis (DM) is a multi‐system autoimmune disorder primarily affecting the skin, skeletal muscle and blood vessels. We describe a rare case of DM after administering the first dose of the Pfizer‐BioNTech COVID‐19 vaccine. The causal relation was suggested based on the timing of the onset and the absence of other triggering factors.
Ultra‐Low‐Loss Silicon Nitride Photonics Based on Deposited Films Compatible with Foundries
Authors: Ji Xingchen , Okawachi Yoshitomo , Gil‐Molina Andres , Corato‐Zanarella Mateus , Roberts Samantha , Gaeta Alexander L. , Lipson Michal 
Published: January 2023

AbstractThe fabrication processes of silicon nitride (Si3N4) photonic devices used in foundries require low temperature deposition, which typically leads to high propagation losses. Here, it is shown that propagation loss as low as 0.42 dB cm−1can be achieved using foundry compatible processes by solely reducing waveguide surface roughness. By postprocessing the fabricated devices using rapid thermal anneal (RTA) and furnace anneal, propagation losses down to 0.28 dB cm−1and 0.06 dB cm−1, respectively, are achieved. These low losses are comparable to the conventional devices using high temperature, high‐stress LPCVD films. The dispersion of the devices is also tuned, and it is proved that these devices can be used for linear and nonlinear applications. Low threshold parametric oscillation, broadband frequency combs, and narrow‐linewidth laser are demonstrated. This work demonstrates the feasibility of scalable photonic systems based on foundries.
Risk of bleeding with factor Xa inhibitors versus unfractionated heparin in patients with acute kidney injury
Authors: Aprilliano Bianca , Giuliano Christopher , Paxton Renee Alexander , Edwin Stephanie B. 
Published: January 2023

AbstractStudy ObjectiveTo compare bleeding and thromboembolic events in patients receiving therapeutic doses of apixaban or rivaroxaban versus unfractionated heparin (UFH) in patients with acute kidney injury (AKI).DesignSingle‐center, retrospective, observational study.SettingAscension St. John Hospital in Detroit, Michigan.PatientsHospitalized adult patients who received therapeutic doses of factor Xa inhibitors (n = 250) or UFH (n = 250) for at least 24 h in the setting of AKI.Measurements and Main ResultsAfter adjusting for confounding factors, patients who received a factor Xa inhibitor experienced a lower risk of composite major and clinically relevant nonmajor bleeding (CRNMB) events compared with UFH (OR: 0.57, 95% CI: 0.34–0.94; p = 0.03). There was a significantly decreased risk of CRNMB events in the factor Xa inhibitor group (OR: 0.55, 95% CI: 0.33–0.91, p = 0.02); however, no significant differences in major bleeding or venous thromboembolism (VTE) were noted.ConclusionsOur results suggest that it may be preferable to continue patients in AKI on factor Xa inhibitors versus transitioning to UFH due to the lower risk of bleeding events.
Impact of pre‐existing mental health disorders on the receipt of guideline recommended cancer treatments: A systematic review
Authors: Wang Yueh‐Hsin , Aggarwal Ajay , Stewart Robert , Davies Elizabeth A. 
Published: January 2023

AbstractObjectiveDisparities in cancer outcomes for individuals with pre‐existing mental health disorders have already been identified, particularly for cancer screening and mortality. We aimed to systematically review the influence on the time from cancer diagnosis to cancer treatment, treatment adherence, and differences in receipt of guideline recommended cancer treatment.MethodsWe included international studies published in English from 1 January 1995 to 23 May 2022 by searching MEDLINE, Embase, and APA PsycInfo.ResultsThis review identified 29 studies with 27 being published in the past decade. Most studies focused on breast, non‐small cell lung and colorectal cancer and were of high or medium quality as assessed by the Newcastle Ottawa Scale. All studies were from high‐income countries, and mostly included patients enrolled in national health insurance systems. Five assessed the impact on treatment delay or adherence, and 25 focused on the receipt of guideline recommended treatment. 20/25 studies demonstrated evidence that patients with pre‐existing mental health disorders were less likely to receive guideline recommended therapies such as surgery or radiotherapy. In addition, there was a greater likelihood of receiving less intensive or modified treatment including systemic therapy.ConclusionsAcross different cancer types and treatment modalities there is evidence of a clear disparity in the receipt of guideline recommended cancer treatment for patients with pre‐existing mental health disorders. The effect of pre‐existing mental health disorders on treatment delay or adherence is under‐researched. Future research needs to include low‐ and middle‐income countries as well as qualitative investigations to understand the reasons for disparities in cancer treatment.
Efficacy of group therapy to reduce mental distress in women with non‐metastatic breast cancer: A systematic review and meta‐analysis of randomized controlled trials
Authors: Rosendahl Jenny , Gawlytta Romina , Ressel Eva , Rodeck Johanna , Strauss Bernhard , Mehnert‐Theuerkauf Anja , Koranyi Susan 
Published: January 2023

AbstractObjectiveGroup treatments have proven to be effective for many mental disorders and showed beneficial effects in patients with medical illness. Aim of this systematic review and meta‐analysis is to summarize the efficacy of group therapy for women with non‐metastatic breast cancer.MethodsWe included studies comparing group therapy for women with non‐metastatic breast cancer to non‐active control groups, active control conditions, and individual psychotherapy. The primary outcome was mental distress, secondary outcomes were quality of life, coping, existential outcomes, fatigue, pain, and side effects. A comprehensive search was conducted in Medline, Web of Science, CENTRAL, PsycINFO, and DARE complemented by a manual search. Random‐effects meta‐analyses were run separately for different types of control groups.ResultsThirty‐seven studies (5902 patients) were included. Small effects on mental distress in favor of group treatment were found (non‐active control groups: n = 19, g = 0.42, 95% CI [0.29; 0.56], I2 = 61.6%; active control conditions: n = 6, g = 0.20, 95% CI [0.06; 0.35], I2 = 0%). Cognitive‐behavioral therapy (CBT) and third wave CBT group approaches proved to be most effective. Group treatments also showed beneficial effects on secondary outcomes, with most profound evidence on quality of life and coping.ConclusionsResults suggest that group interventions have the potential to reduce mental distress in women facing breast cancer. In the light of the considerable heterogeneity of most study effects, there is a need for more rigorous studies to strengthen the promising evidence and for trials examining the impact of patient and intervention characteristics on outcomes.RegistrationPROSPERO international prospective register of systematic reviews, CRD42020184357.
Primary ciliary dyskinesia: A multicenter survey on clinical practice and patient management in Italy
Authors: Ullmann Nicola , Santamaria Francesca , Allegorico Annalisa , Fainardi Valentina , Borrelli Melissa , Ferraro Valentina A. , Proietti Elena , Parisi Giuseppe F. , Romagnoli Vittorio , Lucca Francesca , Gallucci Marcella , Mappa Luigi , Lelii Mara , Amato Doriana , Petrarca Laura , Cimino Giuseppe , Sacco Oliviero , Calogero Claudia , Patria Maria Francesca , Acquafredda Angelo , Ferlisi Annalisa , Maschio Massimo , Kantar Ahmad , Cutrera Renato 
Published: January 2023

AbstractIntroductionThere are no recent data on primary ciliary dyskinesia (PCD) distribution, diagnosis and treatment in Italy.MethodsA descriptive study based on a survey questionnaire. It consisted of three sections (patients, diagnosis, and treatment), and sent to all the Italian PCD Centers.ResultsQuestionnaires obtained from 20/22 centers in 12/20 regions showed that the total number of PCD patients treated at the participating centers was of 416. Out of all centers, 55% follow <20 patients, two centers have >40 patients, and 75% follow both pediatric and adults. Age at diagnosis was between 4 and 8 years in 45% of the centers, <3 years in three centers. Nasal nitric oxide, transmission electron microscopy and ciliary high‐speed video microscopy are performed in 75%, 90%, and 40% of centers, respectively. Immunofluorescence is available in five centers. Genetic analysis is offered in 55% of the centers, and in seven centers >50% of the patients have a known genetic profile. Patients treated at all centers receive inhaled saline solutions, corticosteroids and chest physiotherapy. Prophylactic antibiotics and mucolytics are prescribed in 95% and 50% of the centers, respectively. Pseudomonas infection is treated with oral or inhaled antibiotics.ConclusionsMany Italian centers care for a small number of pediatric and adult patients, and diagnosis is often delayed. We found a great variability in the available diagnostic procedures, as well in the prescribed therapies. Our study will help to uniform diagnostic algorithm and share treatments protocols for PCD in Italy and allowed to set specific national goals.
Machine learning and dynamics based error‐index method for the detection of monsoon onset vortex over the Arabian Sea: Climatology and composite structures
Authors: Sasanka Talukdar , Osuri Krishna K. , Niyogi Dev 
Published: January 2023

AbstractMonsoon onset vortex (MOV) forms over the Arabian Sea near the northern flank of the low‐level jet during the monsoon onset over Kerala (MOK). The study concerns the development and evaluation of an algorithm for detecting and tracking MOVs in regional/global analyses. The first step involves preparing the first‐guess database of MOV locations based on geopotential height, surface and 850 hPa wind magnitude and circulation from ERA5 reanalysis for 1982–2020. Three different approaches: (a) error‐index of MOV, (b) machine‐learning (ML), and (c) combination of error‐index and ML models, are employed to detect MOV. The error‐index method, in which the detected vortex is compared with the idealized vortex, achieves an accuracy of 0.6 with a 0.95 true‐positive‐rate and 0.55 false‐positive‐rate. The best ML models can identify the MOVs in the training samples with maximum accuracy of 0.99. However, their accuracy is limited in tracking the MOVs continuously in the global analyses as they are not trained with wind circulation. The combined error‐index and ML models could detect all the 27 observed MOVs in the ERA5 reanalysis with 5 false‐positives. This approach is tested on IMDAA reanalysis, and the success rate is 0.79 with 6 false‐positives. Temporal analyses show that ∼95% of the MOVs occur during −10 to +20 days from MOK. Composite structures indicate that the MOVs exhibit higher sea‐surface temperatures (>0.3 °C) in the forward sector with 85% cloud cover in the left‐rear sector. Rainfall of 4–5 mm·hr−1 is seen in the left sector. Upper‐level (700–200 hPa) warm core (>3.5°C) and lower‐level (1000–700 hPa) cold‐core (<1°C) is evident. The composite structures of MOVs are almost similar to that of monsoon depressions with higher asymmetry in the forward‐rear sectors. This study may help explore future projections of MOV activity from climate models and its relationship with monsoon rainfall activity.
Data‐driven mixed‐sensitivity control with automated weighting functions selection
Authors: Valceschini Nicholas , Mazzoleni Mirko , Formentin Simone , Previdi Fabio 
Published: January 2023

AbstractSystem identification plays a key role in robust control, as not only it provides a nominal model for model‐based design, but also the estimate of the model uncertainty can be employed for guaranteeing robust stability and performance. In this paper, we investigate the use of kernel‐based identification methods in mixed‐sensitivity control, and we show that, using the uncertainty description returned by such methods, we can alsoautomate the selectionof the optimal weights, which represent the most critical knobs in real‐world applications. We finally compare our approach with a benchmark prediction‐error method on a numerical case study. Simulation results illustrate that kernel‐based identification might be more suited for robust control, due to its low‐bias modeling capability.