bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solution of the problem of swirling fluid flow in a ring channel
Authors: Шарапов Р.Р. , Бойчук И.П. , Савичев А.О. 
Published: June 2023

В статье представлено решение задачи о закрученном течении несжимаемой жидкости в винтовом канале. Такое течение можно рассматривать как приближение вихревого движения реальной жидкости в случае, когда силы инерции преобладают над силами вязкости. Течение характеризуется трехмерностью поля скоростей с сохранением всех трех компонент вектора скорости. Организация таких течений возможна при применении различных видов завихрителей в каналах. Для данного течения реализуется условие параллельности вектора линейной скорости и вектора вихря. На входе в канал жидкость вращается как твердое тело с заданной угловой скоростью. Для такого условия получено решение – функция тока. Общее решение для функции тока представляет собой сумму линейной комбинации функций Бесселя и функции Ломмеля. Полученное решение даст возможность определить характеристики течения, а также проанализировать влияние геометрии кольцевого канала на структуру вихревого течения.
The paper presents a solution to the problem of the swirling flow of an incompressible fluid in a vortex channel. Such flow can be considered as a vortex motion of a real liquid. In this case, the forces of inertia prevail over the forces of viscosity. The flow is characterized by a three-dimensional velocity field with preservation of all three components of the velocity vector. Organization of such flows is possible with application of different types of vortex generators in channels. The condition of parallelism of linear velocity vector and vortex vector is realized for this flow. At the channel inlet, the liquid rotates as a solid with a given angular velocity. For this condition, the solution - the current function - has been obtained. General solution for the current function is a sum of linear combination of Bessel and Lommel functions. The obtained solution makes it possible to determine the flow characteristics as well as to analyze the influence of the annular channel geometry on the structure of the vortex flow.
Study of Contract Change Order (CCO) on Implementation Time in Building Construction Project
Authors: Kamaludin Tutang Muhtar , Rusdin Andi , Nirmalawati Nirmalawati 
Published: June 2023

The aim of this research is to identify the main causes and effects of CCO in the construction of the Palu State Islamic University (IAIN) campus II building project for the Faculty of Tarbiyah and Teacher Training and the Faculty of Sharia and Islamic Economics Lecture Building. Tasks included conducting a field survey via a questionnaire and interviews with main parties; project owner, contractors and consultants who are directly related to the project. It was determined that the top three causes of CCO from project owner, contractor and consultant. The contractor has do CCO at the beginning of the project of 70% respondent, while consultant has changed contract order at mid-project implementation of 50% respondents and 70% at the end project implementation from the contractor. The results that are quite important from this study are the discovery of volume estimation errors and changes in work methods. Errors in estimating volumes are caused by the planning consultant's inaccuracy in planning so that there is a significant difference in volume from the initial contract with conditions in the field so that some work items experience an increase or decrease in volume
Varying severity COVID-19 effects on the blood indicators of insulin-like growth factors family in patients with nonsmall cell lung cancer
Authors: Kit O. I. , Frantsiyants E. M. , Kharagezov D. A , Bandovkina V. A. , Cheryarina N. D. , Pogorelova Yu. A. , Lazutin Yu. N. , Milakin A. G. , Leyman I. A. , Stateshny O. N. 
Published: June 2023

Purpose of the study. An analysis of IGF and their carrying proteins levels in blood serum of patients with non‑small cell lung cancer (NSCLC), depending on the severity of the previous COVID-19 infection.Materials and methods. 60 patients with histologically verified NSCLC T2–3NхM0 receiving treatment at the Thoracic Department (National Medical Research Centre for Oncology, 2020–2021), were included in the study. The control group included 30 NSCLC patients after asymptomatic or mild COVID-19 disease (15 men and 15 women); the main group included 30 (15 men and 15 women) patients after severe or moderate to severe COVID-19. The mean age of patients was 59.11 ± 2.89 years. Blood counts of donors of the same age were used as the norm.Results. The levels of IGF-I, IGF-II, IGFBP2 and IGFBP3 in the blood serum of patients with NSCLC of the main and control groups were higher than those of donors by an average of 2.5, 2.1, 1.7 and 2.7 times, respectively (p < 0.05). The concentration of IGFBP1 was higher in the control group compared to the main group, and decreased in relation to donors: in the control in men and women by 1.4 and 1.9 times, and in the main group by 3.0 and 6.4 times, respectively (p < 0.05). The ratios of IGF and IGFBP1 increased in both groups: IGF-I/IGFBP1 – in the control group from 3.8 to 4.2 times, and in the main group from 7.9 to 14.4 times; IGF-II/IGFBP1 – in the control from 2.4 to 4.5 times, and in the main group from 6.6 to 12.7 times in men and women, respectively (p < 0.05).Conclusions. The level of ligands and almost all of the studied carrier proteins, except for IGFBP1, increases in the blood of patients with NSCLC of both sexes, regardless of the severity of COVID-19. The ratio of IGF-I/IGFBP1 and IGF-II/IGFBP1 in the blood increases in both groups, most significantly in the group with severe and moderate COVID-19, which indicates excessive accumulation of IGF levels and may contribute to a more aggressive course of the malignant process.
Levels of biogenic amines in lung tissues of patients with non-small cell lung cancer after COVID-19 of various severity
Authors: Kit O. I , Frantsiyants E. M. , Kharagezov D. A. , Bandovkina V. A. , Pogorelova Yu. A. , Cheryarina N. D. , Lazutin Yu. N. , Milakin A. G. , Leyman I. A. , Stateshny O. N. , Ushakova N. D. 
Published: June 2023

Purpose of the study. Was to analyze levels of biogenic amines (serotonin and its metabolite 5-HIAA, dopamine, norepinephrine and histamine) in lung tissues of patients with lung cancer with previous COVID-19 infection.Patients and methods. The study was carried out on samples of intact lung tissues, tumor tissues and peritumoral lung tissues obtained during open biopsy while performing radical surgery from patients with morphologically verified non-small cell lung cancer (NSCLC), stage I–IIIA (cT1–3NХM0). The main group included 30 NSCLC patients (15 men and 15 women) after severe or moderate to severe COVID-19 who required hospitalization. The control group included 15 men and 15 women with NSCLC after asymptomatic or mild SARS-CoV-2 infection. The mean age of patients was 59.11 ± 2.9 years. Levels of dopamine, norepinephrine, serotonin, 5-hydroxyindoleacetic acid (5-HIAA) and histamine were measured by ELISA (IBL, Germany).Results. All studied lung tissue samples from men and women of the main group, compared to the control group, showed deficiency of catecholamines with their ratio unchanged, and changes in serotonin metabolism to ensure its stable level. Thus, levels of dopamine in samples of patients of the main group were lower on average by 1.3 times, norepinephrine by 1.3–3.3 times, serotonin by 1.6 times, and 5-HIAA by 1.8–4 times. At the same time, sex differences were observed in histamine levels. Regardless of the COVID-19 severity, levels of diamine in women were lower in the resection line tissue by an average of 2.4 times, and in the peritumoral tissue by 1.6 times, compared with men, but there were no sex differences in the tumor tissue. Conclusion. Apparently, changes in the levels of dopamine, norepinephrine, and serotonin in lung tissues could be associated with the severity of SARS-CoV-2 infection. Since dopamine is involved in counteracting the carcinogenic action of the adrenergic system and in the regulation of various immunocompetent cells in the tumor microenvironment, such changes in the biogenic status in the lungs of patients of the main group could lead to a more severe tumor course.
Parameters of free radical oxidation and antioxidant defense in patients with cervical cancer before and after radical surgical treatment
Authors: Popova N. N. , Goroshinskaya I. A. , Shikhlyarova A. I. , Rozenko D. A. , Menshenina A. P. , Ardzha A.  Yu. , Netyvchenko N. V. , Chekmezova S. A. 
Published: June 2023

Purpose of the study. To analyse free radical oxidation and antioxidant defense in patients diagnosed with early cervical cancer (CC) before and after radical surgical treatment.Patients and methods. Levels of diene conjugates, malondialdehyde (MDA), superoxide dismutase (SOD), catalase, glutathione, glutathione- dependent enzymes, vitamins A and E were determined in 74 women under the age of 45 (48 patients those who were at the stage of surgical treatment with a diagnosis of CC at the National Medical Research Center of Oncology in the period 2017–2020 and 26 healthy women).Results. Patients with early CC showed significant changes in the intensity of lipid peroxidation processes and in antioxidant defense: elevate levels of MDA and diene conjugates, initial decline in the activity of SOD and catalase, low levels of vitamins A and E. These results complete the understanding of the processes occurring in the body of an oncological patient at the initial stage of tumor formation, which does not yet have an obvious clinical manifestation. After total removal of the ovaries, most of the indicators characterizing the enzymatic link of the antioxidant system tend to normalize, while the violation of the content of vitamins E and A (related to the non-enzymatic link of the antioxidant system) worsens.Conclusions. Desynchronization of free radical oxidation processes with multidirectional changes in oxidation and antioxidation in patients with early CC at the stage of radical surgical treatment should be considered from the position of hormone‑ reducing surgery and a resulting complex of changes in the organs and systems of women with cancer.
Cultivation of cells in alginate drops as a high-performance method of obtaining cell spheroids for bioprinting
Authors: Filippova S. Yu. , Chembarova T. V. , Timofeeva S. V. , Mezhevova I. V. , Gnennaya N. V. , Novikova I. A. , Lapteva T.  O. 
Published: June 2023

Purpose of the study. Testing the protocol of obtaining cell spheroids of breast cancer cell cultures for bioprinting by growing in alginate drops.Materials and methods. Cells of breast cancer cell lines BT-20 and MDA-MB-453 were cultured in DMEM medium supplemented with 10 % FBS. Next, the cells were removed from the plastic using a trypsin-V ersene solution and resuspended in a sterile 2 % alginate solution in DPBS to the concentration of 105 cells/ml. Then the alginate solution with the cells was slowly dripped through a 30G needle into a sterile cooled solution of calcium chloride (100 mM) from a height of 10 cm. After polymerization, alginate drops were washed in DMEM and cultured for two weeks in DMEM with the addition of 10 % FBS at 37 °C and 5.0 % CO2.The spheroids formed in the alginate were photographed on the 3rd, 7th, 10th, and 14th days of cultivation, after which they were removed from the alginate by keeping in 55 mM sodium citrate solution with the addition of 20mM ethylenediaminetetraacetic acid (EDTA) and embedded in paraffin blocks according to the standard method, followed by histological examination.Results. Cellular spheroids were formed in both cell cultures already on the 3rd day of cultivation. From the 3rd to the 10th day in both cultures, a uniform growth of cell spheroids was observed with a gradual slowdown in the increase in the size of spheroids by the 14th day of cultivation. On the 10th day the proportion of cells that formed clones (more than 500 μm2 in size) was 25.2 % ± 7.1 % (n = 25) in the BT-20 culture and 38.5 % ± 9.9 % (n = 25) in MDA-MB-453 culture. On the 14th day, BT-20 culture was characterized by spheroids varying little in size and shape, with an average area of 1652 ± 175 µm2, having a dense structure with smooth edges. The spheroids in MDA-MB-453 culture turned out to be more loose and easily deformed, their size and shape varied noticeably, the average area of the spheroids was 2785 ± 345 µm2.Conclusion. The production of spheroids in alginate drops is inferior in speed to the methods of forming cell conglomerates in hanging drops or on microwells, but it surpasses these methods in productivity, which is comparable to the production of spheroids by constant medium stirring on low-adhesive substrates. In addition, the clonal nature of the obtained spheroids leads to an increase in research costs and thus limits their scalability.
New method of modified chemoradiotherapy for cancer of the upper and middle ampullary rectum
Authors: Gevorkyan Yu. A. , Soldatkina N. V. , Chernyak M. N. , Gusareva M. A. , Bondarenko O. K. , Dzhenkova E. A. , Dashkov A. V. , Kolesnikov V. E. , Petrov D. S. , Tolmakh R. E. , Savchenko D. A. 
Published: June 2023

The last decade is characterized by significant progress in the treatment of rectal cancer (reduction in the number of relapses to 5–6 % with the use of prolonged radiation therapy) before surgery. The greatest success has been achieved in the treatment of cancer of the lower ampulla of the rectum, when it is possible to develop a complete clinical response of the rectal tumor to chemoradiotherapy. Nevertheless, the requirement issues to improve the results of treatment of cancer of the upper and middle ampullar rectum with an increase in the survival of patients remain. Which makes it relevant to develop new methods, that increase the effectiveness of the treatment of rectal cancer.The method of modified chemoradiotherapy for cancer of the upper ampulla of the rectum was developed in our study. The method is as follows: at the first stage, one day before the start of radiation therapy, the patient undergoes superselective catheterization of the superior rectal artery through the radial or femoral artery, followed by regional administration of radiomodifying chemotherapy drugs: cisplatin 50 mg and fluorouracil 500 mg. In one day, patients begin to undergo a course of conformal remote large- fraction radiation therapy to the primary focus and metastasis pathways for 5 sessions with a single focal dose of 5 Gy to a total focal dose of 25 Gy using a low-energy linear accelerator. During the entire course of radiation therapy, fluorouracil 500 mg is administered daily intravenously for 30 minutes in 30 minutes before the session. Surgical intervention with the sampling of material for research is carried out 6–8 weeks after the radiation therapy is completed. To assess the effectiveness of the modified chemoradiotherapy, the stage of tumor regression was determined according to the RECIST scale, and the level of therapeutic pathomorphology of the tumor according to Dworak was determined during a morphological study of the rectal tumor removed during the operation.The developed method of modified chemoradiotherapy makes it possible to achieve regression of the rectal tumor in a short time, reduce the time and increase the effectiveness of treatment. The method of modified chemoradiotherapy is intended for patients with cancer of the upper and middle ampullar rectum T3-4N0-2M0, for whom radiation therapy is indicated as the first stage of treatment, after which resection of the rectum is performed in a standard volume.
Programa Educativo Efectos de la Suplementación de Hierro en Gestantes en el Centro de Salud Jangas
Authors: Rojas Tello Gilma Aly , Córdova Cassia Willy Edgardo , Olivares Cordova Jovanna Hasel , Norma Diaz Rojas Celedonia , Flores de Garcia Flora 
Published: June 2023

Objetivo determinar los efectos de la Suplementación de Hierro diaria y semanal en Gestantes en el Centro de Salud de Jangas. Material y métodos: el tipo de investigación fue cuasi experimental, descriptiva, comparativo y prospectivo. La muestra de estudio estuvo constituida por 60 mujeres gestantes. El procesamiento de la información y analices se utilizó el programa SPSS versión 20.0. los resultados encontrados se observa en el grupo 1 de dosis diaria supervisada al inicio de la suplementación la gestante tuvieron 12,98 mg/dl y al final fue de 13,44 mg/dl, la diferencia fue estadísticamente significativo con un valor de p=0.000; grupo 2 dosis semanal supervisada el inicio fue de 13,21 mg/dl y al final del estudio fue de 13,55 mg/dl siendo esta diferencia estadísticamente significativa p=0.00; el grupo 3 dosis diaria no supervisada al inicio fue de 13,19 mg/dl y al final descendió a 12,97 mg/dl siendo el valor de p=0,154 no teniendo ninguna diferencia significativa, respecto a los efectos colaterales se encontró el sabor metálico 60% y el estreñimiento 40%.fueron las molestias más frecuentes en las gestantes. Conclusión que al final del programa fue efectiva la suplementación de Hierro de dosis diaria supervisada fue eficaz la profilaxis a diferencia de dosis diaria no supervisada que no es adecuada la profilaxis, luego de haber recibido el programa educativa.
A Wide View of the Galactic Globular Cluster NGC 2808: Red Giant and Horizontal Branch Star Spatial Distributions
Authors: Johnson Christian I. , Calamida Annalisa , Kader Justin A. , Ferraro Ivan , Pilachowski Catherine A. , Bono Giuseppe , Mastrobuono-Battisti Alessandra , Rest Armin , Zenteno Alfredo , Zocchi Alice 
Published: June 2023

Abstract
Wide-field and deep DECam multiband photometry, combined with HST data for the core of the Galactic globular cluster NGC 2808, allowed us to study the distribution of various stellar subpopulations and stars in different evolutionary phases out to the cluster tidal radius. We used the C

ugi
= (u − g) − (g − i) index to identify three chemically distinct subpopulations along the red giant branch and compared their spatial distributions. The most light-element-enriched subpopulation (P3) is more centrally concentrated; however, it shows a more extended distribution in the external regions of the cluster compared to the primordial (P1) and intermediate (P2) composition populations. Furthermore, the P3 subpopulation centroid is off-center relative to those of the P1 and P2 groups. We also analyzed the spatial distribution of horizontal branch stars and found that the relative fraction of red horizontal branch stars increases for radial distances larger than ≈1.′5, while that of the blue and hotter stars decreases. These new observations, combined with literature spectroscopic measurements, suggest that the red horizontal branch stars are the progeny of all the stellar subpopulations in NGC 2808, i.e., primordial and light-element enhanced, while the blue stars are possibly the result of a combination of the “hot-flasher” and the “helium-enhanced” scenarios. A similar distribution of different red giant branch subpopulations and horizontal branch stars was also found for the most massive Galactic globular cluster, ω Cen, based on combined DECam and HST data, which suggests that the two may share a similar origin.
Observable Signature of Merging Stellar-mass Black Holes in Active Galactic Nuclei
Authors: Tagawa Hiromichi , Kimura Shigeo S. , Haiman Zoltán , Perna Rosalba , Bartos Imre 
Published: June 2023

Abstract
The origin of stellar-mass black hole mergers discovered through gravitational waves is being widely debated. Mergers in the disks of active galactic nuclei (AGNs) represent a promising source of origin, with possible observational clues in the gravitational-wave data. Beyond gravitational waves, a unique signature of AGN-assisted mergers is electromagnetic emission from the accreting black holes. Here we show that jets launched by accreting black holes merging in an AGN disk can be detected as peculiar transients by infrared, optical, and X-ray observatories. We further show that this emission mechanism can explain the possible associations between gravitational-wave events and the optical transient ZTF 19abanrhr and the proposed gamma-ray counterparts GW150914-GBM and LVT151012-GBM. We demonstrate how these associations, if genuine, can be used to reconstruct the properties of these events’ environments. Searching for infrared and X-ray counterparts to similar electromagnetic transients in the future, once host galaxies are localized by optical observations, could provide a smoking-gun signature of the mergers’ AGN origin.
Modeling Chondrule Dust Rim Growth with Ellipsoidal Monomers
Authors: Xiang C. , Carballido A. , Matthews L. S. , Hyde T. W. 
Published: June 2023

Abstract
Fine-grained dust rims (FGRs) surrounding chondrules in carbonaceous chondrites encode important information about early processes in the solar nebula. Here, we investigate the effect of the nebular environment on FGR porosity, dust size distribution, and grain alignment, comparing the results for rims comprised of ellipsoidal and spherical grains. We conduct numerical simulations in which FGRs grow by collisions between dust particles and chondrules in both neutral and ionized turbulent gas. The resultant rim morphology is related to the ratio ϵ of the electrostatic potential energy at the collision point to the relative kinetic energy between colliding particles. In general, large ϵ leads to a large rim porosity, large rim grain size, and low growth rate. Dust rims comprised of ellipsoidal monomers initially grow faster in thickness than rims comprised of spherical monomers, due to their higher porosity. As the rims grow and obtain a greater electrostatic potential, repulsion becomes dominant, and this effect is reversed. Grain size coarsening toward the outer regions of the rims is observed for low- and high-ϵ regimes, and is more pronounced in the ellipsoidal case, while for the medium-ϵ regime, small monomers tend to be captured in the middle of the rims. In neutral environments, ellipsoidal grains have random orientations within the rim, while in charged environments ellipsoidal grains tend to align with maximum axial alignment for ϵ = 0.15. The characterization of these FGR features provides a means to relate laboratory measurements of chondrite samples to the formation environment of the parent bodies.