bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of hepatic adverse events due to quetiapine by using the common data model
Authors: Ko SooJeong , Chang Se‐Hyun , Chung Yeon Woong , Seo Young‐Gyun , Kang Dong‐Yoon , Kim Kwangsoo , Chang Dong‐Jin , Choi In Young 
Published: June 2023

AbstractPurposeQuetiapine is a drug used to treat schizophrenia, bipolar disorder, and major depressive disorder. However, it can cause mild or severe hepatic adverse events and rarely fatal liver damage. This study was aimed at investigating hepatic toxicity caused by quetiapine use by analyzing the information captured from hospital electronic health records by using the Observational Medical Outcomes Partnership common data model (CDM).MethodsThis was a retrospective observational study involving a nested case–control method. A CDM based on an electronic health record database from five hospitals between January 2009 and May 2020 was used. We analyzed the status of quetiapine use, adverse events, and hepatic impairment.ResultsThe numbers of patients with non‐serious and severe hepatic adverse reactions were 2566 (5.05%) and 835 (1.64%) out of 50 766 patients, respectively. After adjusting for covariates, the odds ratio of hepatic adverse events was 2.35 (95% CI: 2.03–2.72), and the odds ratio of severe hepatic adverse events was 1.76 (95% CI: 1.16–2.66).ConclusionOur findings suggest that quetiapine should be cautiously used, and hepatic function should be monitored in patients using quetiapine because it can cause mild or severe hepatic adverse events, complications, and in rare cases, fatal liver damage.
Laser intensity and surface distribution identification at weld interface during laser transmission welding of thermoplastic polymers: A combined numerical inverse method and experimental temperature measurement approach
Authors: Le Anh‐Duc , Akué Asséko André Chateau , Nguyen Thi‐Ha‐Xuyen , Cosson Benoît 
Published: June 2023

AbstractThe determination of the laser intensity profile necessary to weld two thermoplastic parts is crucial for understanding and optimizing the laser welding process in polymers and composite materials. Traditional methods of measuring the laser beam intensity profile, such as laser beam profiling techniques, can be difficult to implement and expensive. In this paper, we present the development of a technique that combines a numerical inverse method with experimental temperature measurements to determinate the laser intensity distribution at the weld interface. This technique does not require specialized or expensive equipment and accounts for variations in laser beam intensity caused by different components and interfaces. The technique uses thermocouple sensors to measure interface temperatures during welding, and an analytical gaussian model to estimate the laser intensity distribution at the weld interface. The model is then used as input data in a numerical heat transfer model. The technique is validated through experimental investigations on transparent and absorbent Polylactic acid polymers.
Professional skills training in developing digital materials through augmented and virtual reality applications
Authors: Gokbulut Bayram , Durnali Mehmet 
Published: June 2023

AbstractA good deal of research has stressed that teaching staff are expected to continuously improve their profession. However, we observed that there is a need for more practical‐based research investigating the practices being adopted by teaching staff. Therefore, the present research aimed to explore the effect of a 9‐day practical‐based training on faculty members' and teachers' levels of professional competence in developing digital materials through augmented and virtual reality applications. The study group consisted of 15 faculty members and 15 teachers. “Digital Material Development Competence Scale” was applied as pre‐ and posttests, and semi‐structured interview questions were employed to collect data. As a result, both the quantitative and qualitative data evidenced that the training increased both faculty members' and teachers' levels of supposed professional development significantly. Subsequently, the participants' views revealed that the following contributed to the development of their skills in developing digital materials, technology use, integrating their pedagogical knowledge into technological knowledge, and lifelong learning. They are (a) receiving training on the use of augmented and virtual reality applications; (b) practicing sample applications with these tools; (c) experiencing mutually collaborative, hands‐on, and interactive learning; (d) with the help of highly motivated and expert trainers; and (e) with efficient collaboration between faculty members and teachers. In closing, not only did we report and discuss the results in line with relevant professional development and lifelong learning theories, but we also presented research activities and results as concrete examples in the context of efficient learning for the professional development of teaching staff as adults.
An active learning Kriging‐based multipoint sampling strategy for structural reliability analysis
Authors: Tian Zongrui , Zhi Pengpeng , Guan Yi , He Xinghua 
Published: June 2023

AbstractIn order to effectively and accurately assess the failure probability of mechanical structures, this paper proposes a multi‐point sampling active learning reliability analysis method called AKMP. First, a GA‐Halton sequence is introduced to make the initial samples well dispersed and homogeneous in the design space. Second, a new learning function FELF is constructed to efficiently update the Kriging model, which takes into account the relationship between the location of the sampling points and the performance fun. Then, a combination of NCC criterion and multipoint sampling strategy is proposed to further improve the convergence efficiency, which can effectively terminate the active learning process. Finally, numerical and engineering cases are tested to verify the application performance of the proposed AKMP. The results show that the method has superior performance in terms of both accuracy and failure probability efficiency, and can reduce the computational resources of the active learning process.
Manganese sources and rates impact plant Mn concentrations and soil Mn fractions
Authors: Montgomery Ashleigh , Herndon Elizabeth , Sams Carl , Jagadamma Sindhu 
Published: June 2023

AbstractManganese (Mn) is an essential micronutrient for all organisms. In plants, Mn plays a critical role in photosynthesis and as a structural component of enzymes. In soils, Mn exists as different fractions of varying availability to plants. Mn fertilizers can be used to increase Mn availability to plants but are easily converted from a plant‐available fraction (exchangeable Mn) to an unavailable fraction (Mn‐oxides). Little research has been done in agricultural settings on soil Mn fractions; thus, the objective of this experiment was to study the effect of Mn additions on soil Mn fractions and plant Mn concentration. A greenhouse experiment was conducted by growing soybean (Glycine max) treated with three Mn application rates (recommended or 1×, 10×, and 50×) of two sources (MnSO4 and Mn ethylenediamine tetraacetic acid [MnEDTA]). Soil Mn fractions (Mehlich‐1 extractable, exchangeable, organic‐bound, Mn‐oxide, residual) were quantified via sequential Mn extraction procedures. Bioavailability was evaluated by measuring soybean leaf Mn concentrations. Both fertilizer types increased available soil Mn fractions. Leaf Mn concentration increased with MnSO4 50× application at the V3 stage and decreased with MnEDTA addition at the V3 and R2 stages. Mn additions likely resulted in the conversion of Mn into unavailable fractions. This was amplified by higher application rates, where total Mn increased by 18.5%, but available Mn decreased by 4.3% relative to initial soil values. Thus, our study showed that adding Mn to soils does not necessarily increase plant‐available Mn.
Water‐Triggered Segment Orientation of Long‐Lasting Anti‐Biofouling Polyurethane Coatings on Biomedical Catheters via Solvent Exchange Strategy
Authors: Zhang Zhenyan , Wang Lei , Liu Jiaying , Yu Huan , Zhang Xu , Yin Jinghua , Luan Shifang , Shi Hengchong 
Published: June 2023

AbstractThe formation of biofilm and thrombus on medical catheters poses a significant life‐threatening concern. Hydrophilic anti‐biofouling coatings upon catheter surfaces with complex shapes and narrow lumens are demonstrated to have the potential in reducing complications. However, their effectiveness is constrained by poor mechanical stability and weak substrate adhesion. Herein, a novel zwitterionic polyurethane (SUPU) with strong mechanical stability and long‐term anti‐biofouling is developed by controlling the ratio of sulfobetaine‐diol and ureido‐pyrimidinone. Once immersed in water, as‐synthesized zwitterionic coating (SUPU3 SE) would undergo a water‐driven segment reorientation to obtain much higher durability than its direct drying one, even under various extreme treatments, including acidic solution, abrasion, ultrasonication, flushing, and shearing, in PBS at 37 °C for 14 days. Moreover, SUPU3 SE coating could achieve a 97.1% of exceptional reducing protein fouling, complete prevention of cell adhesion, and long‐lasting anti‐biofilm performance even after 30 days. Finally, the good anti‐thrombogenic formations of SUPU3 SE coating with bacterial treatment are validated in blood circulation through an ex vivo rabbit arteriovenous shunt model. This work provides a facile approach to fabricating stable hydrophilic coating through a simple solvent exchange to reduce thrombosis and infection of biomedical catheters.
Mechanical properties and constitutive model of the buckling restraint rebar under compression loads
Authors: Jia Junfeng , Zhao Nannan , Bai Yulei , Cao Yanhui , Cheng Shoushan , Fan Ping 
Published: June 2023

AbstractBuckling of the longitudinal rebar is one of the main forms of plastic hinge failure in reinforced concrete (RC) columns after an earthquake. This rebar buckling significantly impacts the seismic bearing capacity and energy dissipation capacity. To restrain the development of longitudinal rebar buckling behavior and delay the degradation of lateral strength in RC columns, this paper developed a new type of buckling restraint rebar (BRR) consisting of three components: longitudinal rebar, a restraint sleeve, and foam material. First, the BRR mechanical properties under compression and tension‐compression cyclic loading were obtained through quasi‐static loading tests. Then, the BRR compression and tension‐compression cyclic loading processes were numerically simulated based on ABAQUS finite element software. The simulated results were compared with the test results. Finally, a stress–strain constitutive model for this new BRR was proposed based on this study. Results showed that the restraint sleeve could significantly enhance the lateral stiffness and the bearing capacity of longitudinal reinforcement after yielding. The compressive performance of BRR was mainly affected by the length and wall thickness of the sleeve. The cyclic performance was mainly affected by the length of the sleeve and the clearance between the sleeve and the reinforcement. The BRR constitutive model proposed in this paper can accurately reflect the influence of restraint sleeves on the stiffness of longitudinal reinforcement after yielding.
Enhanced High Power Impulse Magnetron Sputter Processes
Authors: Gaines J. R. 
Published: June 2023

SummaryHigh power impulse magnetron sputtering (HIPMS) has emerged as a useful approach for depositing highly dense and smooth coatings of electrically conductive materials. Recent advances in power supply technology have further enabled HIPMS through the addition of a positive kick in the pulse cycle which supplies a bias at the surface of the sputter target which expels sputter target ions and sends more charged adatoms toward the substrate. This has been demonstrated with critical materials like diamond‐like carbon and plasmonic materials. Material specific pulse magnitudes and durations can be developed to achieve new novel thin film morphologies.
Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro
Authors: Fuchs Daniel , Rohrer Bley Carla , Morandi Luca , Tonon Caterina , Weyland Mathias S. , Nytko Katarzyna J. 
Published: June 2023

AbstractBackgroundCombined chemoradiation offers a promising therapeutic strategy for dogs with glioma. The alkylating agents temozolomide (TMZ) and lomustine (CCNU) penetrate the blood‐brain barrier, and doses for dogs are established. Whether such combinations are clinically advantageous remains to be explored together with tumour‐specific markers.ObjectiveTo investigate if triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro.MethodsWe evaluated the sensitising effect of CCNU alone and in combination with TMZ‐irradiation in canine glioma J3T‐BG cells and long‐term drug‐exposed subclones by using clonogenic survival and proliferation assays. Bisulphite‐SEQ and Western Blot were used to investigate molecular alterations.ResultsTMZ (200 μM) or CCNU alone (5 μM) reduced the irradiated survival fraction (4 Gy) from 60% to 38% (p = 0.0074) and 26% (p = 0.0002), respectively. The double‐drug combination reduced the irradiated survival fraction (4 Gy) more potently to 12% (p < 0.0001).After long‐term drug exposure, both subclones show higher IC50 values against CCNU and TMZ. For CCNU‐resistant cells, both, single‐drug CCNU (p = 0.0006) and TMZ (p = 0.0326) treatment combined with irradiation (4 Gy) remained effective. The double‐drug‐irradiation combination reduced the cell survival by 86% (p < 0.0001), compared to 92% in the parental (nonresistant) cell line. For TMZ‐resistant cells, only the double‐drug combination with irradiation (4 Gy) reduced the cell survival by 88% (p = 0.0057) while single‐drug treatment lost efficacy.Chemoresistant cell lines demonstrated higher P‐gp expression while MGMT‐methylation profile analysis showed a general high methylation level in the parental and long‐term treated cell lines.ConclusionsOur findings indicate that combining CCNU with TMZ‐irradiation significantly reduces canine glioma cell survival. Such a combination could overcome current challenges of therapeutic resistance to improve overall patient survival.
On‐farm myringotomy as treatment for persistent otitis media in five Dutch veal calves
Authors: van de Mheen Robert 
Published: June 2023

AbstractOtitis media (presumably caused by Mycoplasma bovis) is a frequently encountered problem with big economic implications in the Dutch veal calf industry. Conservative treatment using antibiotics, NSAIDs and corticosteroids is regularly unsuccessful. The affected calves usually start to waste due to pain and decreased feed intake. This report describes a novel treatment option, performing a myringotomy (surgical opening of the eardrum), combined with local antibiotic and corticosteroid therapy. The outcome was positive; in four out of five calves, the clinical signs resolved within 3 weeks after intervention. On‐farm myringotomy is a promising treatment option in persistent otitis media.
Bat use of abandoned mines throughout Nevada
Authors: Moran Megan L. , Steven Janet C. , Williams Jason A. , Sherwin Richard E. 
Published: June 2023

AbstractAbandoned mines offer important roosting habitat for several species of bats throughout the western United States. Currently, abandoned mine reclamation programs are tasked with closing abandoned mines to ameliorate safety, health, and environmental hazards found in and around these sites. Without appropriate pre‐closure evaluations to determine use of mine workings prior to closure, bats that depend on abandoned mines may be negatively impacted. To mitigate impacts of abandoned mine reclamation on bats, surveyors typically conduct pre‐closure biological evaluations and recommend wildlife compatible closures (e.g., bat gates) for ecologically important sites. Due to hazardous conditions found in many abandoned mines, internal surveys cannot always be conducted, and external surveys are not reliable for determining underground habitat or inferring past, future, or potential use of mines by bats when they are absent during external surveys. The purpose of our study was to use internal mine surveys to examine relationships between abandoned mine use by bats and characteristics of the mine and landscape, including portal area and shape, number of portals, mine depth, elevation, proximity to water and land use type. We found that surface features including land use type, distance to water, and elevation were associated with bat use, as were several mine features including depth of workings and portal shape. To best conserve sensitive species of bats, it is essential that pre‐closure biological evaluations be as detailed as possible to enhance biological understanding of species' roosting associations and distribution throughout the landscape. Further information will best facilitate development of ecologically sound closure recommendations for abandoned mine openings.
Classroom Learning Environments and Assessment Practices in Science Classrooms in Western Australia
Authors: Koul Rekha B. 
Published: June 2023

AbstractThe research described in this paper was aimed at identifying exemplary assessment practices in secondary science classes. In the first stage, following a review of the literature, a six-scale instrument of 48 items was trialed with a sample of 470 students from grades eight, nine and ten in 20 science classrooms in three Western Australian schools. Based on internal consistency reliability data and exploratory factor analysis, refinement decisions resulted in a five-scale instrument that was named the Student Perceptions of Assessment Questionnaire (SPAQ). In the second stage, the SPAQ was used with an attitude scale, and a self-efficacy scale. This survey was administered to a larger sample of 960 students from 40 science classes from the same grades as in the first stage. Statistical analyses confirmed the validity and reliability of the SPAQ. Based on the results of this survey exemplary teachers were identified. In the third and last stage interviews with teachers and students were conducted. Classes of these exemplary teachers were also observed. These exemplary teachers were found to be thorough in their teaching, giving students enough time to prepare for the assessment, giving students freedom to choose from a variety of assessments and were flexible in teaching and assessment. They also demonstrated in-depth understanding of the science topics they were teaching.
Affective Student–Teacher Relationships and Students’ Engagement: A Cross–Cultural Comparison of China and The Netherlands
Authors: Roorda Debora , Chen Mengdi , Zee Marjolein 
Published: June 2023

AbstractAmple evidence has been found for the association between affective, dyadic student–teacher relationships and students’ engagement with schoolwork in Western, individualistic countries. There are far fewer studies, however, examining this association in Eastern, collectivistic countries. As maintaining harmony in interpersonal relationships plays a crucial role in collectivistic countries, student–teacher relationships may even be more important in collectivistic countries than in individualistic countries. In the present study, we therefore investigated cross–cultural differences in the strength of associations between student–teacher relationship quality and students’ engagement based on data from the Netherlands (a Western country) and China (an Eastern country). The Dutch sample included 789 students (51.1% girls) and the Chinese sample included 588 students (52.9% girls) from grades 3 to 6 of elementary school. Students reported about the quality of their relationship with their teacher (closeness, conflict) and their behavioral and emotional engagement with schoolwork. Hierarchical linear modeling showed that the positive association between closeness and both behavioral and emotional engagement was stronger for the Chinese sample than for the Dutch sample. In contrast, the negative association between conflict and both behavioral and emotional engagement did not differ across countries. To conclude, closeness may be more relevant for Chinese students’ engagement than would be expected based on Western studies, whereas conflict seems to be equally harmful in both cultures. Therefore, developing relationship-focused interventions for Chinese teachers and students seems important, either by adapting Western programs or by developing new programs especially designed for Chinese schools.
Effective Interpersonal Relationships: On the Association Between Teacher Agency and Communion with Student Outcomes
Authors: den Brok Perry , van Tartwijk Jan , Mainhard Tim 
Published: June 2023

AbstractThis chapter reviews research that has investigated the link between teacher-student interpersonal relationships and student outcomes. First, prior research reviews investigating the relationship between these two sets of variables is discussed. Such research overwhelmingly shows the importance of warm and supportive relationships for both cognitive and affective outcomes, with affective outcomes also acting as an intermediary between the other two variables. Next, interpersonal theory is discussed, that conceptualizes interpersonal relationships from a systems perspective and distinguishes between the communion and agency dimensions of relationships. At the end of the contribution, research is reviewed that has used interpersonal theory as its leading framework and that has mapped students’ perceptions of interpersonal relationships with one particular instrument, the Questionnaire on Teacher Interaction (QTI). Findings show that both interpersonal dimensions are positively related to cognitive as well as affective outcomes, either jointly or separately, with agency being more strongly related to cognitive outcomes and communion being more strongly related to affective outcomes.
The Effects of a Short Self-Access Online Training for Practicum Preparation on the Depths of Reflection of Preservice Teachers
Authors: Wang Ye , Ko James , Wang Peng 
Published: June 2023

AbstractEnhancing preservice teachers’ critical reflections on their newly acquired knowledge and experience is crucial for promoting their teaching skills and performance. However, it is a challenging task to teach reflections and increase their depths of reflection. Previous research has succeeded to help preservice teachers reflect in a full-term taught course. However, little empirical research demonstrated the effects of a short self-access online training program on the depths of reflection of preservice teachers. Framed in Ryan and Ryan’s (High Educ Res Dev 32(2):244–257, 2013) reflection depth model, this study adopted a quasi-experimental research design to examine the depths of reflection after attending a short online training of four 30-min sessions varied in training session order and session content. Data of 555 reflective statements were identified subsequently in 120 reflective logs of 30 preservice teachers in a teacher education university in northern China. The results showed a significant difference between the experimental and control groups, indicating that a short self-access online training program has beneficial effects on preservice teachers’ reflections during practicum preparation. While the depths of the reflective statements identified were relatively shallow, the frequency of the reflective statements did not decrease with their depths. Additionally, topics in the online training sessions significantly affected the depths of preservice teachers’ reflections, while the training sequence did not. This study is conducive to designing the relevant online training programmes to promote the depths of reflection of preservice teachers in teacher education programmes.