bluuebunny/crossref_metadata_2025_split huggingface dataset:
S-44-2: ANTIHYPERTENSIVE EFFECT OF GALANGIN IN RENAL ARTERY STENOSIS-INDUCED HYPERTENSIVE RATS
Authors: Chaihongsa Nisita , Sangartit Weerapon , Rattanakanokchai Siwayu , Bunbupha Sarawoot , Pakdeechote Poungrat , Maneesai Putcharawipa 
Published: January 2023

Background:
Galangin is a natural flavonoid found in honey and Alpinia officinarum. Several reports have suggested the anti-mutagenic, antioxidant, anti-proliferative, and apoptotic effects. However, the antihypertensive effect of galangin in renovascular hypertension has not been investigated.

Aims:
This study aims to investigate the effect of galangin on blood pressure and cardiac changes in renovascular hypertension.

Methods:
Male Sprague Dawley rats (180–220 g) were induced hypertension by clipping the left renal artery, 2-kidney-1-clip (2K-1C). After 3 weeks of the induction period, galangin (30 and 60 mg/kg) and losartan (10 mg/kg) were given to the rats for 4 weeks (n = 8/group). Blood pressure and cardiac function were evaluated at the end of the experimental day. The level of angiotensin-converting enzyme (ACE) activity, angiotensin II, and oxidative stress markers were assessed in the plasma and cardiac tissue of rats. The protein expression of angiotensin
II receptor type 1 (AT1R), transforming growth factor-beta 1 (TGF- β 1) and collagen type I (Col I) were determined in cardiac tissue. Statistical analysis was carried out by one-way ANOVA followed by Tukey post hoc test. A p value less than 0.05 was considered statistically significant.

Results:
Hypertension and cardiac dysfunction and hypertrophy were observed in 2K-1C rats compared to the sham-operated rats (p < 0.05). Treatment with galangin (30 and 60 mg/kg) decreased high blood pressure and improved cardiac function as well as alleviated left ventricular hypertrophy in 2K-1C hypertensive rats (p < 0.05). This result was related with the reduction of systemic ACE activity and angiotensin II levels in 2K-1C hypertensive rats that were treated with galangin (p < 0.05). Moreover, the expression of AT1R, TGF- β 1 and Col I in cardiac tissue was modulated by treatment with galangin (p < 0.05).
Additionally, galangin showed anti-oxidative effects as it reduced the production of superoxide and malondialdehyde levels in cardiac tissue of rats (p < 0.05).

Conclusion:
Galangin exhibited an antihypertensive effect and alleviated cardiac alteration in renovascular hypertensive rats. The underlying mechanism might be related to its inhibitory effects on renin-angiotensin system and anti-oxidative properties renal artery stenosis-induced hypertensive rats. Furthermore, the beneficial effect of galangin on heart might mediate the suppression of AT1R, TGF- β 1 and Col I pathway.
S-45-2: THE EVALUATION OF LEFT VENTRICULAR GEOMETRY AND LEFT VENTRICULAR EJECTION FRACTION BETWEEN CANCER PATIENTS BEFORE AND AFTER CHEMOTHERAPY
Authors: Karunawan Niyata Hananta , Jusuf Iin Irnawati , Tonang Alvin , Wahab Zulfahmi , Rachmandita Rheno , Pandeiro William Alfred Lapian 
Published: January 2023

Objection:
This study aimed to compare the left ventricular (LV) geometry and left ventricular ejection fraction (LVEF) before and after chemotherapy in Cancer Patients

Methods:
This study was a cohort retrospective study design, the study compared the LV geometry and LVEF at baseline and 2-months after anthracyclines administration in cancer patients. Subject participants were aged more than 18 and received doxorubicin for the treatment of cancer at Dr Adhyatma MPH Tugurejo General Hospital from January until May 2022. Two-dimensional (2D) transthoracic echocardiographic (TTE) was performed to assess mass index (LVMI), mass (LVM), relative wall thickness (RWT), end-diastolic diameter (LVEDD), end-systolic diameter (LVESD), interventricular septal end-diastole (IVSd), posterior wall end-diastole (PWd) of the left ventricle at two-time points. The primary outcome of the study was LV Geometry and LVEF follow up after 2 months of doxorubicin therapy. The Data were analyzed univariate and bivariate followed by the chi-square test and paired T-test.

Results:
The Data of 72 cancer patients were dominated by females (87%) and a mean age of 51.19 ± 9.83 years old. Subject included patients with breast cancer (83.3%), non-Hodgkin's lymphoma (13,9%), and sarcomas (2,8%). After a 2-months period, the left ventricular ejection fraction (LVEF) decreased significantly from 70.98 ± 7.97 % to 66.70 ± 8.24 % (p < 0.001). Relative wall thickness (RWT) decreased significantly from 0.39 ± 0.12 to 0.35 ± 0.08 (p: 0.006), and left ventricular end-systolic diameter (LVESD) increased significantly from 25.41 ± 4.35 mm to 27.73 ± 4.58 mm (p < 0.001). LVMI (84.86 ± 28.99 g/m(2) to 80.16 ± 26.58 g/m(2)), LVM (131.75 ± 50.33 g to 126.00 ± 45.34 g), LVEDD (43.06 ± 5.06 mm to 43.98 ± 4.58 mm), IVSd (8.98 ± 2.25 mm to 8.43 ± 2.14 mm) and PWd (8.26 ± 2.30 mm to 7.75 ± 1.42 mm) did not change significantly (p > 0.05). Higher blood pressure was associated with post-cancer therapy.

Conclusion:
The effects of doxorubicin administration after two months were a lower LVEF, a lower RWT and a higher LVESD compared to before cancer therapy.
S-47-1: THE POTENTIAL OF AI IN HYPERTENSION TREATMENT
Authors: Okuno Yasushi 
Published: January 2023

Deep learning, which has been the driving force behind AI in recent years, has been shown in various research reports to be as powerful as or more powerful than humans in the medical field. Specifically, deep learning techniques are being applied to images, time series data, biomolecular information, and natural language for medical images, clinical values, genomic information, and medical records in electronic medical records, respectively. In particular, AI for recognizing and diagnosing medical images has been shown to have high accuracy in various diseases including cancer, and it is expected that various types of AI for image diagnosis will be put to practical use in the medical field within the next five years. In addition to highly accurate diagnostic imaging, the benefits of AI for medicine include genomic diagnosis, decision support to reduce the burden on medical professionals, correction of regional disparities in medicine through AI, and self-medication by patients themselves using AI. Furthermore, AI is expected to make it possible to do things that are difficult to do with human knowledge and experience, such as predicting the future of a patient's medical condition, suggesting the best treatment for each individual, and quickly and appropriately extracting medical significant information from a large amount of medical knowledge around the world.
As an application of AI and data science to the healthcare domain, we have worked on big data analysis of the Iwaki health checkup cohort in Hirosaki City, Japan and successfully developed AI to predict the early onset of 11 diseases, including hypertension, from the health checkup data. In addition to predicting disease onset, we have also developed an AI that estimates intervention points and proposes optimal plans to improve health and prevent disease onset. In this presentation, I would like to introduce the potential of big data and AI in hypertension by illustrating these our research.
S-47-6: BIG DATA AND REAL-WORLD DATA FOR HYPERTENSION MANAGEMENT IN THE ERA OF DIGITAL HEALTH
Authors: Okada Mihoko 
Published: January 2023

There has been an increasing number of research papers on hypertension studies using healthcare big data. Real-world data (RWD) is a term used for observational studies in a way that appears similar to big data, and is considered as the data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources including EHRs, claims and billing activities, product and disease registries, patient-generated data in home-use settings, data gathered from other sources that can inform on health status such as mobile devices, as described by the U.S. FDA. For the purpose of this presentation, the term RWD will be used regardless of big data or not, unless a distinction between big data and RWD is necessary.
In the era of Digital Health, recent hypertension management research shows a prominent trend towards the use of mobile technology that enables self-management of hypertension. By digital health, we mean eHealth and mHealth collectively. We have conducted literature search on digital health studies that targeted hypertension management using PubMed. There are many studies on mHealth for improving lifestyle where smartphone is considered a convenient tool to aid in the treatment of hypertension through the use of apps targeting self-management behavior for blood pressure control. In some studies, data obtained from the apps are combined with clinical data or linked to existing databases for cohort studies. Other studies focus on the use of mHealth technologies for medication adherence, improved communication between clinicians and patients, and or education to patients and to their family. Studies have shown potential of digital interventions in self-management, changing the behavior of people with chronic conditions, with discussions of the feasibility, acceptability, and effectiveness. Effectiveness of digital interventions has been assessed in many trials although most of the studies are small scale. There are also some studies on digital therapeutics (DTx) and their trials for hypertension, where DTx are digital health tools for therapeutic interventions.
In this presentation, we provide an overview of on-going efforts to obtain evidence to determine the overall effect of digital health technology on blood pressure control, medication adherence, and lifestyle changes for people with hypertension. Then we discuss barriers to and enablers of adoption of technology-based interventions, and need of more large-scale well-designed epidemiological research.
S-48-2: ENERGY EXPENDITURE OF OLDER PATIENTS WITH TYPE 2 DIABETES AND HOW IT RELATES TO FRAILTY
Authors: Kastukawa Fuminori 
Published: January 2023

Because of the increased anabolic threshold for skeletal muscle synthesis (anabolic threshold), a multicomponent exercise program with an emphasis on resistance training has been recommended for older subjects with frailty risk. However, increasing energy expenditure with physical activity might be also helpful for increasing nutritional intakes and thereby reducing sarcopenia risk.
We have evaluated energy expenditure in older subject with type 2 diabetes (T2DM), which is associated with an increased risk of sarcopenia. Total energy expenditure (TEE) showed no difference between patients with T2DM and non-diabetic controls. However, wide variations in PAL (i.e. TEE/basal metabolic rate) were found, and difference in TEE between the highest and lowest PAL tertile was ∼500 kcal/d, and estimated daily protein intake for the highest and lowest PAL was 1.53 and 1.20 g/kg, respectively.
Non-basal energy expenditure showed weak but statistically significant correlations with fat free mass, grip power, and phase angle, and related to reduced sedentary time and increased moderate intensity locomotive physical activity. Longitudinal studies are further needed to evaluate the role of PA energy expenditure for reduced risk of frailty and sarcopenia.
S-49-3: THE ASSOCIATION BETWEEN CALF CIRCUMFERENCE AND MID-UPPER ARM CIRCUMFERENCE AND PREVALENCE OF HYPERTENSION: FINDINGS FROM THE PURE CHINA STUDY
Authors: Lang Xinyue , Li Wei 
Published: January 2023

Objective:
To investigate the association of calf circumference (CC), mid-upper arm circumference (MUAC) and their derivative indexes (waist-to-arm and waist-to-calf circumference ratio) with prevalence of hypertension.

Methods:
A total of 47,677 individuals aged 35–70 years with measurement of CC, MUAC and blood pressure were available for analysis. CC and MUAC were measured under standardized training. The association of CC and MUAC with hypertension were tested in logistic regression analyses and reported as odds ratio (OR) with 95% CI. Subgroup analysis for BMI was conducted.

Results:
CC and MUAC were positively correlated with hypertension in the crude model. When adjusted for the BMI and waist, larger CC and MUAC were associated with a lower hypertension prevalence rate. It was stable after adjusted for demographic characteristics, lifestyle behaviors and health status [OR of 0.96(0.91, 1.03), 0.90(0.83, 0.97), and 0.85(0.80, 0.90) for Q2, Q3, and Q4 for CC, P for trend < 0.05, respectively; OR of 1.00(0.94, 1.07), 0.94(0.88, 1.00), and 0.82(0.76, 0.88) for Q2, Q3, and Q4 for MUAC, P for trend < 0.05, respectively]. Larger waist-to-arm and waist-to-calf circumference ratios were correlated with a higher risk of hypertension. For the overweight (BMI 24–28 kg/m2) group, as the CC or MUAC increased, a significant trend for a lower prevalence of hypertension was observed [OR of 0.87(0.77, 0.98), 0.84(0.75, 0.95), and 0.79(0.69, 0.90) for Q2, Q3, and Q4 for CC, P for trend < 0.05, respectively; OR of 0.86(0.76, 0.97), 0.77(0.69, 0.87), and 0.71(0.63, 0.80) for Q2, Q3, and Q4 for MUAC, P for trend < 0.05, respectively].
S-52-2: PARAMETERS INDICATING HYPERTENSION PREVALENCE IN THREE-YEAR FOLLOW-UP STUDY OF INDIVIDUALS WITH HIGH NORMAL BLOOD PRESSURE
Authors: Kalos Theodoros , Dimitriadis Kyriakos , Andrikou Ioannis , Manta Eleni , Fragoulis Christos , Konstantinidis Dimitris , Tatakis Fotis , Leontsinis Ioannis , Matzouranis Emmanouil , Kariori Maria , Sotiris Drogaris , Polyzos Dimitris , Filippou Christina , Tsioufis Kostas 
Published: January 2023

Objective:
Assess the relation of blood pressure response to treadmill exercise test in subjects with high normal blood pressure (BP) while sympathetic overactivity assessed by muscle sympathetic nerve activity (MSNA) and arterial stiffening are linked with development of hypertension (HTN).

Design and method:
100 consecutive subjects with high normal BP according ESC guidelines (systolic BP = 130 to 139mmHg and/or diastolic BP = 85 to 89mmHg), underwent a negative for ischemia treadmill exercise test (Bruce protocol). Arterial stiffness was evaluated based on carotid-femoral pulse wave velocity (PWV). Sympathetic drive was assessed by (MSNA). A new index the SBP/MET-slope ((peakSBP minus restingSBP)/(peakMET minus 1)) was used. Follow-up was scheduled every 6 months for 3 consecutive years, where BP measurements were assessed in office and with ambulatory BP monitoring (ABPM). All participants offered lifestyle advise to lower their BP. Endpoint was development of HTN either with OffBP or ABPM. Then they divided into Group I those who developed HTN and Group II without HTN.

Results:
From 100 subjects (54 ± 8 years, 42 males, baseline office BP: 132/82 mmHg, 24-hour BP: 122/76 mmHg) 40 developed HTN (Group I) and 50 developed HRE (BP > 210mmHg in men and > 190mmHg in women). Group I vs II had higher HRE (75%vs13%, p = 0.026) with intermediate stage intervals of 3 min (160vs147mmHg, p = 0.068) and 6 min (181vs164mmHg, p = 0.035). The SBP/MET-slope in Group I was increased in all stages till peak exercise independently of sex type (stage1: 6.25vs4.25, stage2: 7.6vs5.3, peak: 7.22vs5.1, p = 0.035). Their exercise capacity was reduced (10vs11.5METs, p = 0.05) as their maximum exercise heart rate (154vs164, p = 0.001). They demonstrated higher levels of PWV (8.35vs7.5m/sec, p = 0.043) and MSNA levels (37vs31 bursts, p = 0.04) both correlated with development of hypertension (p = 0.002), while did not differ regarding their metabolic profile at the followup. The correlation Echocardiographicly LVMI did not differ, but LVEDD (47vs45 mm, p = 0.02), E/A ratio of mitral valve inflow (0.92vs1.05, p = 0.034) and left atrium diameter (3.8vs3.6 mm p < 0.1) were statistically significant. At their initial ECG had shorter P wave duration (101.3vs93.2, p = 0.013) and QRS duration (93.4vs85.7, p = 0.006). In ABPM they demonstrated higher night systolic BP (116vs112mmHg, p < 0.04).

Conclusion:
In subjects with high normal BP, MSNA identifies a state of increased sympathetic overdrive, PWV demonstrates arterial stiffening and exercise testing provides a prognostic value as a hypertension screening tool acknowledging a state of increased systemic vascular resistance progressing to development of hypertension.
S-52-3: ROLE OF NOVEL ECHOCARDIOGRAPHIC METHODS TO DETECT EARLY MYOCARDIAL DYSFUNCTION IN WOMEN WITH PREECLAMPSIA
Authors: Hristova Krasimira Atanasova , Tselov Nikolay , Marinov Rumen , Stamenov Georgi , Chacheva Kristina , Michova Marina , Georgiev Daniel , Panayotova Jeni , Persenska Sanina , Dimova Neli , Racheva Anelia 
Published: January 2023

Normal pregnancy is associated with reversible changes in both systolic and diastolic mechanics, consistent with an increase in preload and decrease in afterload and systemic vascular resistance. The aim of the study is to evaluate left ventricular cardiac mechanics via speckle tracking echocardiography in a population of pregnant women with per partum cardiomyopathy and preeclampsia(PE) after invitro fertilization (IVF) during different stages of pregnancy.
The study population included 525 pregnant women with PE, after IVF, 100 of them with multiple pregnancy (46.5 ± 3 years) and 30 healthy nonpregnant women (33 ± 4years).Apical and basal short axis and apical view for three, two and four chamber for 2D images were acquired (65 ± 7 frames/s) during the first, second and third trimester of the pregnancy, as well as up to two months post partum. The curves of longitudinal(GLS), circumferential(GCS), radial strain(GRS) and LVT /LVUR were extracted using a commercial software.

Results:
Peak LVT and LVUR increased significantly in the 3rd trimester in both pregnancy groups (13.48 ± 2.90°,13.12 ± 3.30?,16.83 ± 3.61?,P < 0.001; and -111.52 ± 23.54°/sec,-107.40 ± 26.58?/sec,-144.30 ± 45.14?/sec, P < 0.001; in the 1st, 2nd, and 3rd trimester, respectively.The pregnants with twins have the highest value for LVT and LVUR compare with other pregnants (p < 0.01), but in the last trimester, the time to peak LVUR is prolonged. An independent correlation was found between the change in LVT and LV end-systolic volume in 1st and 3rd trimester (r = 0,56). Peak LVUR at the 3rd trimester correlated significantly with LV end-diastolic volume. Multiple regression analysis indicates that only systolic blood pressure (r = 0.394, P = 0.005) was an independent predictor for increased LV torsion. Arterial hypertension (AH) and prevalence of preeclampsia (PE) are more often in IVF group. Longitudinal strain decreased significantly (p < 0.001) during 3th trimester in women with AH and PE. Global longitudinal strain measures of the LV were non-significantly different between the different groups in first and second trimester (GLS-20.6 ± 3,14 vs.-19,29 ± 2,17).There are not found significant differences for GCS and GRS during pregnancy.

Conclusions:
During pregnancy LV twist and peak untwisting rate increase in the 3rd trimester and correlate with end-systolic and end-diastolic volume, respectively. Blood pressure and condition of multiple pregnancy are independently associated with increased torsion during pregnancy and may predict the new onset heart failure and perinatal cardiomyopathy. Global longitudinal strain is the main predictor of new onset peripartum cardiomyopathy
S-54-2: ROLE OF THE THIAZIDE-SENSITIVE NA+:CL- COTRANSPORTER IN THE BLOOD PRESSURE-LOWERING EFFECT OF POTASSIUM RICH DIETS.
Authors: Castaneda-Bueno Maria 
Published: January 2023

Evidence supports that a negative correlation exists between dietary potassium consumption and blood pressure levels in the population. It has also been well documented that increasing dietary potassium consumption, increases urinary sodium excretion. The molecular mechanisms that contribute to this latter phenomenon are under investigation. Recent evidence suggests that the thiazide-sensitive Na+:Cl- cotransporter, NCC, may play a key role in this regard. For instance, in mouse models, variations in blood pressure and natriuresis observed in response to altered potassium intake are significantly blunted in NCC deficient mice.
NCC activity indirectly modulates urinary potassium excretion and NCC activity is tightly regulated in response to subtle alterations in plasma potassium concentration that occur in response to dietary potassium consumption changes. The molecular mechanisms that mediate this modulation are complex and their characterization has significantly advanced in recent years. Such mechanisms will be discussed in the presentation. The most recent advances will be highlighted.
S-54-3: PREDICTION AND PREVENTION OF THE ONSET OF HYPERTENSION FROM THE VIEWPOINT OF ESTIMATED 24-HOUR SALT EXCRETION AND PHYSICAL FITNESS TEST
Authors: Kato Kiminori , Ishigami Tomoaki , Sone Hirohito 
Published: January 2023

Objective:
Both dietary salt and physical activity contribute substantially to development and progression of blood pressure elevation. Earlier detection of blood pressure change by daily simple procedures are effective for health promotion less expensively. We performed both longitudinal and cross-sectional observations for the subjects with annual comprehensive health checkup to test relationships among daily salt intake, physical activity, and blood pressure elevation. Methods: We performed following three observations. A)Body weights, interviewed salt intakes (i-NaCl), and estimated salt intakes (e-NaCl) for single spot urine (Tanaka formula) were measured and compared to blood pressure change monthly for one year in total 17,794 participants. B) To test significance of shared e-NaCl information to health promotions, we shared e-NaCl to total 98,908 participants individually and, subsequently, annual-mean e-NaCl was compared for 5 years. C) To test significance of physical activity for blood pressure elevations, we performed 5-year follow up study for total 22,972 participants to examine the onset of hypertension and physical activity as followings; duration of single-leg balance with eyes closed (sec), grip strength (kg), forward bending (cm), whole body reaction time (msec), vertical jump distance (cm), and supine leg-up (sec), respectively.

Results:
A) Only e-NaCl was found to have a strong correlation with the monthly mean systolic blood pressure as shown in a figure. B) By sharing e-NaCl information with participants, annual mean of e-NaCl decreased significantly from 9.22 g/day (male) and 8.79 g/day (female) in 2012 to 9.03 g/day (male) and 8.63 g/day (female) in 2017. C) Even when adjusted for gender, age, BMI, systolic and diastolic blood pressure of first year, single-leg balance with eyes closed and forward bending were significantly associated with the onset of hypertension.

Conclusion:
Since e-NaCl is affected by salt excretion due to sweating, it was presumed that the amount of salt to be excreted in urine correlated well with seasonal changes in blood pressure. In addition, e-NaCl measurement is a good tool that can be used for health guidance to examinees for their life style promotion. It was found that flexibility and a sense of equilibrium are related to the onset of blood pressure.