bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Kremen2 predicts worse prognosis in colon cancer
Authors: Long Junxian , Cong Fengyun , Wei Yousheng , Liu Jungang , Tang Weizhong 
Published: April 2023

Background: Colon cancer (CC) is the fifth most prevalent cancer around the globe and poses a major risk to human health. Even though Kremen2 serves as a prognostic indicator in individuals with malignant tumours, its role in evaluating the prognosis of individuals with colon cancer has not been confirmed.Methods: Here, we examined the protein expression of Kremen2 in CC tissues and paired adjacent normal tissues by immunohistochemistry (IHC), then analyzed the clinical and RNA-seq data presented in The Cancer Genome Atlas (TCGA) database to confirm the relationship between Kremen2 levels and CC. In addition, the associations between Kremen2 mRNA expression and infiltrating immune cells were examined.Results: The study showed that the mRNA expression and protein level of Kremen2 were increased in CC tissues compared with adjacent normal tissues. According to Kaplan–Meier analysis, high Kremen2 expression in CC was linked to poor overall survival and progression-free survival. Clinical correlation analysis highlighted that a high level of Kremen2 expression was strongly linked with tumour progression, particularly lymph node metastasis. Cox regression analysis highlighted that Kremen2 was an independent prognostic indicator for CC. Bioinformatic studies highlighted that Kremen2 might be associated with the immune status in CC.Conclusion: Increased Kremen2 could serve as a potential prognostic CC biomarker.
A Study on the Spontaneous Ignition of Some Ligneous Pellets
Authors: Ferreira Tânia , Marques Edmundo , Paiva João Monney , Pinho Carlos 
Published: April 2023

A preliminary non-exhaustive study was conducted on the ignition of some ligneous biomass pellets inside a laboratory scale traveling bed furnace. The experiments consisted in the measurement of the ignition time of volatiles released by six different types of pellets, obtained from wood species found in the Portuguese forest, namely Pinus pinaster, Acacia dealbata, Cytisus scoparius, Cistus ladanifer, Paulownia cotevisa and Eucalyptus globulus. The experiments were carried out at corrected furnace temperatures of 359, 381, 403, 424 and 443 °C, using two different pellet sizes and with batches of 6 and 8 g of pellets. The ignition time was determined measuring the time elapsed between placing the batch of pellets on the traveling grate and the volatiles’ ignition moment. Its dependency was linear, and an increase in ignition time with the furnace temperature was verified. Pinus pinaster was the species that presented a higher ignition time and Cytisus scoparius the shortest. For the same pellets size, an increase in the mass of batches led to shorter ignition times.
A Longitudinal Study of the Relationship of Adiponectin with Reproduction in Infertile Women Undergoing IVF/ICSI Treatment, and an Experimental Study in Human Granulosa Cells
Authors: Qin Lixian , Sitticharoon Chantacha , Petyim Somsin , Keadkraichaiwat Issarawan , Sririwichitchai Rungnapa , Maikaew Pailin , Churintaraphan Malika 
Published: April 2023

This study investigated the roles of adiponectin in IVF treatment during Phase I (the basal stage before gonadotropin administration), Phase II (approximately 8 days after gonadotropin administration), and Phase III (on the ovum pick-up day), as well as the effects of adiponectin on CYP19A1 and the FSH receptor (FSHR) mRNA expression in a human granulosa-like tumor cell line (KGN). In human subjects (a longitudinal study, n = 30), blood samples were collected in all phases, while follicular fluid (FF) was only collected in Phase III. The participants were classified into successful and unsuccessful groups based on the determination of fetal heartbeats. KGN cells were treated with adiponectin/FSH/IGF-1 (an experimental study, n = 3). There was no difference in the adiponectin levels between successful and unsuccessful pregnancies in the FF (Phase III) and in serum (all phases), as well as among the three phases in both groups. Serum FSH (Phase I) was positively associated with serum adiponectin in the unsuccessful group, but it had a negative association in the successful group (all phases). Serum adiponectin and serum FSH (Phase I) were positively correlated in the unsuccessful group, whereas they were negatively correlated (all phases) in the successful group. The serum adiponectin levels (Phase III) were significantly higher than in the FF in unsuccessful pregnancies, but there was no difference in successful pregnancies. FF adiponectin concentrations were negatively correlated with serum LH in successful subjects. In KGN cells, adiponectin had no influence on CYP19A1 and FSHR mRNA expression. High adiponectin levels in serum compared to FF (Phase III) in unsuccessful subjects might negatively impact IVF treatment.
Transcranial Magneto-Acoustic Stimulation Attenuates Synaptic Plasticity Impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model
Authors: Chu Fangxuan , Tan Ruxin , Wang Xin , Zhou Xiaoqing , Ma Ren , Ma Xiaoxu , Li Ying , Liu Ruixu , Zhang Chunlan , Liu Xu , Yin Tao , Liu Zhipeng 
Published: April 2023

The neuropathological features of Alzheimer’s disease include amyloid plaques. Rapidly emerging evidence suggests that Piezo1, a mechanosensitive cation channel, plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure, but the importance of Piezo1-mediated mechanotransduction in brain functions is less appreciated. However, apart from mechanical stimulation, Piezo1 channels are strongly modulated by voltage. We assume that Piezo1 may play a role in converting mechanical and electrical signals, which could induce the phagocytosis and degradation of Aβ, and the combined effect of mechanical and electrical stimulation is superior to single mechanical stimulation. Hence, we design a transcranial magneto-acoustic stimulation (TMAS) system, based on transcranial ultrasound stimulation (TUS) within a magnetic field that combines a magneto-acoustic coupling effect electric field and the mechanical force of ultrasound, and applied it to test the above hypothesis in 5xFAD mice. Behavioral tests, in vivo electrophysiological recordings, Golgi–Cox staining, enzyme-linked immunosorbent assay, immunofluorescence, immunohistochemistry, real-time quantitative PCR, Western blotting, RNA sequencing, and cerebral blood flow monitoring were used to assess whether TMAS can alleviate the symptoms of AD mouse model by activating Piezo1. TMAS treatment enhanced autophagy to promote the phagocytosis and degradation of β-amyloid through the activation of microglial Piezo1 and alleviated neuroinflammation, synaptic plasticity impairment, and neural oscillation abnormalities in 5xFAD mice, showing a stronger effect than ultrasound. However, inhibition of Piezo1 with an antagonist, GsMTx-4, prevented these beneficial effects of TMAS. This research indicates that Piezo1 can transform TMAS-related mechanical and electrical stimuli into biochemical signals and identifies that the favorable effects of TMAS on synaptic plasticity in 5xFAD mice are mediated by Piezo1.
HUBUNGAN PENGETAHUAN REMAJA TERHADAP KEJADIAN GIZI LEBIH PADA REMAJA DI KOTA PEKANBARU
Authors: Sellia Juwita  , Sara Herlina  , Siti Qomariah  , Wiwi Sartika  
Published: April 2023

Gizi pada setiap jenjang kehidupan anak sangat penting termasuk pada masa remaja, masa remaja merupakan masa peralihan dari anak-anak menjadi orang dewasa. Remaja atau usia sekolah merupakan masa yang paling mudah mengalami masalah gizi karena pada masa tersebut merupakan masa peralihan dari anak kedewasa terlebih pada remaja perempuan, factor frekuensi makan, waktu makan yang tidak teratur, dan banyaknya jenis makanan yang dikonsumsi mengakibatkan adanya gangguan gizi pada remaja perempuan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan remaja tentang gizi lebih terhadap kejadian gizi lebih pada remaja di Kota Pekanbaru. Metode penelitian menggunakan survey analitik pendekatan crossectional, penelitian ini dilakukan secara daring di Kota Pekanbaru. Sampel dalam penelitian ini adalah remaja yang berada di Kota Pekanbaru dengan teknik pengambilan sampel random sampling jumlah sampel sebanyak 335 orang. Hasil analisis univariat diperoleh 181 orang (54%) memiliki pengetahuan baik dan sebanyak 154 orang (46%) memiliki pengetahuan kurang, dan hasil uji bivariat diketahui bahwa terdapat hubungan pengetahuan remajatentang gizi lebih terhadap kejadian gizi lebih dengan nilai Pvalue < 0,05 (Pvalue 0,000). Dapat disimpulkan bahwa pengetahuan remaja tentang gizi lebih mempengaruhi kejadian gizi lebih pada remaja di Kota Pekanbaru.
Evaluasi CPPB IRT dan Penyusunan Rekomendasi HACCP pada UMKM Tempe a-Zaki di Bandar Lampung
Authors: Ulfa Masayu Nur , Wahyuningtyas Amalia , Marvie Ilham , Pangastuti Hesti Ayuningtyas 
Published: April 2023

Tempeh is a fermented food composed primarily of soybeans that is a nutrient-dense, cost-effective, and sustainable functional source of protein. Tempeh production, especially in Indonesia, is done usually in household scale. For its development, the producers should be maintaining their product quality, especially in food safety management such as good manufacturing pratices (GMP) and Hazard Analysis Critical Control Point (HACCP). The objectives of this study was to identify the suitability of GMP implementation and to compose HACCP plan. This study took place in a-Zaki tempeh household producer in Bandar Lampung. This study was conducted with descriptive quantitative approach. Primary data (observations and interviews) and secondary were collected as the information.. For GMP evaluation, the obtained data was compared with the regulation of food and drug regulatory agency. The result showed that a-zaki tempeh household producer were categorized into level III of IRTP due to 10 minors deviations, 3 major deviations, 4 serious deviations, and 0 critical deviations so that an internal audit needs to be held every 2 weeks. For HACCP, the producer had not yet designed and implemented HACCP plan.
Efektivitas Pembelajaran Tema Selalu Berhemat Energi Bermuatan Sustainability Menggunakan Model Problem Based Learning Terhadap Pemahaman Konsep
Authors: Arlindra Rizma Saputri  , Siti Patonah  , Mudzanatun  
Published: April 2023

The aim of the study was to test the effectiveness of the problem-based learning model with sustainability on the conceptual understanding of fourth grade students at SD Negeri 01 Protomulyo. The research carried out was of a quantitative type using an experimental method in the form of a One-Group Pretest – Posttest Design used in one group. The results obtained from the research show that student learning outcomes have increased compared to the results of the pretest and posttest, so that it can be concluded that the problem based learning model contains sustainability is effective on science learning outcomes for fourth grade students at SD N 01 Protomulyo. Based on the results of this study, suggestions can be given so that teachers can implement problem-based learning models with sustainability in order to create effective and enjoyable learning for students.

Tujuan penelitian ialah untuk menguji keefektifan model problem based learning bermuatan sustainability terhadap pemahaman konsep siswa kelas IV SD Negeri 01 Protomulyo. Penelitian yang dilaksanakan berjenis kuantitatif dengan menggunakan metode eksperimen berbentuk One-Group Pretest–Posttest Design yang digunakan pada satu kelompok. Hasil yang didapat dari penelitian menampilkan bahwasanya hasil belajar siswa meningkat dibandingkan hasil pretest dan posttest, sehingga dapat diambil simpulan bahwasanya model Problem Based Learning bermuatan sustainability efektif terhadap hasil belajar IPA siswa kelas IV SD N 01 Protomulyo. Berdasar hasil penelitian ini, dapat diberikan saran agar guru bisa mengimplementasikan model Problem Based Learning bermuatan sustainability agar tercipta pembelajaran efektif serta menyenangkan untuk siswa.
Taboo Language as a Means of the Category of Impoliteness
in the English Language
Authors: Belyutina Yulia 
Published: April 2023

The article considers means of the linguistic category of impoliteness, and the research is based on the pragmatic approach in linguistics. Impoliteness is associated with the so-called communicative sabotage, behavior violating communicative norms. To interpret the speaker’s verbal behavior one should judge not only by the wording, but take into consideration the communicative situation, which, in some cases, is of paramount importance. In the research, impoliteness
is understood as a language used to offend or / and is perceived as offensive. But the analysis touches upon the instances with marked vocabulary, which cause damage to the addressee. All the tabooed words in English are classified into four big semantic groups. The first group includes the semes related to the Christian
religion that used to be associated with blasphemy but now have lost their initial capacity, especially among teenagers. The second group embraces roots with the meaning ‘sexual relations,’ ‘excretion’ but nowadays they lack their original status in most contexts and mostly perform the function of catharsis. The third group is mentioned as zoovocatives and, according to the research, are used to diminish the addressee’s importance, to rise in the estimation of the public. The last group comprises the words with the seme ‘blood’ which no longer refers to Jesus’s blood and has undergone desemantization. It mostly performs expletive function – emphasizes the speaker’s negative emotions.
Labor Use of Polish Prisoners of War in the Camps of Central Russia,
1920–1921
Authors: Rodionov Ivan 
Published: April 2023

Based on the materials of the federal and regional archives of Central Russia, the article analyzes the practice of labor use of prisoners of war of the Polish-Soviet War in the camps of Central Russia in 1920–1921. The author examined the regulatory framework for the labor use of prisoners of war of the Polish army. The study showed the professional composition of Polish prisoners of war, as well as their level of education. In fact, Polish prisoners of war were a large group of educated special-
ists whose work was used in various fields. The regions also requested the necessary number of Polish prisoners of war for certain labor tasks, partially covering the shortage of labor. An attempt to organize labor squads from captured Poles is considered. But, labor squads were formed in Moscow and in those provinces where there was a high concentration of prisoners of war of the Polish army. In the rest, for the most part, labor unions were never formed. With the beginning of the repatriation of Polish prisoners of war, they began to gradually remove from work and look for a replacement for them. Before repatriation, prisoners of war submitted applications
to the sub-departments of forced labor to issue them salaries, funds earned from forced labor, which they were supposed to receive on the day of departure to their homeland. The labor of Polish prisoners of war was paid at local rates, and they
were equated with Red Army soldiers in terms of supply.
The Image of King in «Norna-gests þáttr»:
the Epic Chieftain and the King from Chronicles
Authors: Malkova Anna 
Published: April 2023

The article deals with specific qualities of designing the image of the king Olav Tryggvason into narrative space of the «Norna-gests þáttr», which was written at the end of XIV c. and included into «Olafs saga Tryggvasonar en mesta». The main specific of this kind of narrative consists in the fact, that epic heroes are
near to historical persons.
The basement of the research is the interpretative and comparative textual approaches. It is also guided by the research of E.A. Gurevich, who translated and commented the text of the «Norna-gests þáttr», having devoted several scientific articles to it. The recieved results show that the formation of the image of the ruler in the text of the strand is carried out through building a common space of cultural memory for epic heroes and historical figures and comparing their actions and achievements.
BIMBINGAN BELAJAR MEMBACA BAGI SISWA USIA SEKOLAH DASAR DI DESA GOLO LANGKOK, RAHONG UTARA, MANGGARAI, NUSA TENGGARA TIMUR
Authors: Fransiska Jaiman Madu  
Published: April 2023

Bimbingan Belajar Membaca bagi Siswa Usia Sekolah Dasar di Desa Golo Langkok, Rahong Utara, Manggarai, Nusa Tenggara Timur. “Dengan membaca buku, engkau bisa menjelajahi dunia tanpa harus meninggalkan kursimu”. Pepatah itu disampaikan Plummer terkait betapa pentingnya membaca. Kemampuan membaca tentu menjadi tuntutan utama bagi semua orang. Dengan membaca, seseorang dapat mengetahui banyak hal seperti sejarah, berita, dan informasi. Membaca menjadi salah satu kompetensi dasar yang dipelajari sejak sekolah dasar. Para siswa wajib belajar membaca sejak duduk di bangku sekolah dasar. Akan tetapi, apa jadinya jika masih terdapat siswa sekolah dasar yang belum bisa membaca? Deskripsi itu tergambar pada diri siswa di desa Golo Langkok. Pada observasi awal ditemukan bahwa 17 siswa sekolah dasar belum mampu membaca. Temuan tersebut dianggap sebagai sebuah masalah. Berdasarkan hal tersebut, solusi yang telah dilakukan adalah bimbingan belajar membaca bagi siswa usia sekolah dasar di Desa Golo Langkok, Kecamatan Rahong Utara. Siswa yang mengalami kesulitan membaca itu membutuhkan bimbingan belajar membaca secara intensif. Adapun metode kegiatan yang telah dilakukan, yakni (1) menganalisis situasi, (2) mendiagnosa masalah, (3) mengategorikan siswa berdasarkan kemampuan, dan (4) melakukan kegiatan bimbingan belajar membaca. Setelah kegiatan bimbingan belajar membaca, hasil kegiatan menunjukkan bahwa tingkat kemampuan membaca siswa SD di Desa Golo Langkok meningkat.
UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK BATANG BAJAKAH TAMPALA (Uncaria gambir (W.Hunter) Roxb) PADA TIKUS DIABETES
Authors: Alexandra Francisca Diana , Frethernety Agnes , Amiani Winney , Aprelea Reza Nathasya 
Published: April 2023

Penelitian bertujuan membuktikannya aktivitas antihiperglikemia ekstrak etanol batang Bajakah Tampala (Uncaria gambir (W.Hunter) Roxb.) pada tikus yang diinduksi streptozotocin. Penelitian dilakukan secara eksperimental yang menggunakan rancangan true experiment posttest only control group design. Ekstrak bajakah Tampala diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak dibuat dengan dosis 50mg/kgBB, 75mg/KgBB, 100mg/KgBB pada tikus diabetes. Penurunan kadar glukosa darah kontrol negatif (27,27%) dalam perlakuan ini lebih rendah dibandingkan glibenclamide (35,12%). Penurunan kadar glukosa darah terbesar dicapai dosis 100 mg/kgBB yaitu sebesar 44,85%. Perlakuan pemberian ekstrak etanol bajakah pada berbagai tingkat dosis diakhir pengamatan seluruhnya menunjukkan presentase penurunan kadar glukosa darah namun tidak berbeda nyata (p > 0,05). Hasil penelitian ini tidak menunjukkan penurunan kadar glukosa darah yang berbeda nyata

Kata kunci: : antihperglikemia, glukosa darah, diabetes, bajakah
Prevention of falls in the elderly and senile patients with cardiovascular diseases
Authors: Tkacheva O. N. , Kotovskaya Yu. V. , Eruslanova K. A. , Alimova E. R. , Runikhina N. K. , Naumov A. V. , Frolova E. V. 
Published: April 2023

A fall is defined as an event, which results in a person coming to rest inadvertently on the ground or floor or other lower level, except in cases, which are the result of a blow, loss of consciousness, sudden paralysis or an epilepsy [1]. Falls and fear of falling cause serious health problems, which, in turn are associated with high injury rate, high medical costs and a negative impact on quality of life. Older and senile patients with cardiovascular disease (CVD) are at high risk of falling. However, in clinical practice, the prevalence of falls and the risks of falls are not well understood and underestimated by physicians and patients themselves. An increased risk of falling is associated with various factors, such as drugs, structural heart disease, orthostatic hypotension and arrhythmias, as well as gait and balance disorders, physical weakness, sensory disturbances. These risks are especially important with the growing number of older people with cardiovascular disease. All physicians involved in the care of patients with CVD should pay attention to the assessment, prevention and treatment of falls in adults with heart disease, and the treatment of cardiovascular disease in patients at risk of falls.
Efficacy and safety of reperfusion therapy for ST-segment elevation myocardial infarction in patients older than 75 years
Authors: Duplyakova P. D. , Pavlova T. V. , Duplyakov D. V. 
Published: April 2023

The review analyzes studies on the efficacy and safety of reperfusion therapy for ST-segment elevation myocardial infarction in patients over 75 years of age. Registers data on the positive impact of reperfusion treatments on outcomes in older patients hospitalized with STEMI are given. Particular emphasis is put on the need for prospective studies to determine the optimal tactics for managing older and oldest older patients with STEMI.
Geriatric cardiology - an imperative of our time
Authors: Kotovskaya Yu. V. 
Published: April 2023

Cardiovascular disease is the leading cause of morbidity and mortality, especially in older adults. The older are characterized by a combination of CVD with other non-infection chronic diseases, changes in cognitive and functional status, social and economic circumstances. To date, there are no formalized guidelines for managing patients in response to all issues, since historically clinical recommendations are «disease-centric», while older patients with CVD require an inclusive and integrative patient-centric approach to insure comprehensive health care. Integration of the basic principles of cardiovascular disease management and the principles of geriatrics is becoming increasingly necessary to provide high quality care for older patients.
Frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 con leucemia linfoblástica aguda de células B en el Instituto Nacional de Salud del Niño de San Borja
Authors: Sánchez Pinto Francisco José Melchor , Manassero Morales Gioconda , Correa Guerrero Mónica Carola , Romero Guerra Guillermo Frank , Fuentes Vera Julissa 
Published: April 2023

Objetivo: Describir la frecuencia de los genes de fusión BCR-ABL, E2A-PBX1, MLL-AF4, y TEL-AML1en pacientes con leucemia linfoblástica aguda del Instituto Nacional de Salud del Niño de San Borja.
Materiales y métodos: Se estudiaron 375 muestras de pacientes pediátricos, diagnosticados con leucemia linfoblástica aguda, recibidas en el Servicio de Genética, la cuales se detectaron los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 en médula ósea o sangre periférica, utilizando la reacción en cadena de la polimerasa con transcriptasa reversa (RT-PCR).
Resultados: Del total de muestras, 58 fueron positivas para los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1, las cuales tuvieron siguientes frecuencias: 2.13%, 4.53%, 0.53% y 8.27% respectivamente.
Conclusiones: El gen de fusión TEL-AML1, fue el más frecuente en nuestra población pediátrica.