bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long term use of Cytopoint® in atopic dogs
Authors: Gober Margaret , Amodie Deb , Mellencamp Marnie , Hillier Andrew 
Published: August 2023

Abstract

Cytopoint® (lokivetmab) has been shown to be effective for the short-term treatment of dogs with allergic and atopic dermatitis but there are no studies at US label dosing (at least 2 mg/kg every 4–8 weeks as necessary) which evaluate long-term usage. The objective of this study was to follow a cohort of dogs receiving Cytopoint to treat their canine atopic dermatitis (CAD) over 12 months. The initial phase of this study evaluated a dog’s pruritus following monthly injections (up to 3 injections) of Cytopoint. Dogs who achieved pruritus < 36 mm using a Pet Owner Pruritus Visual Analogue Scale (PVAS) scoring system during the initial phase, were included in this study. Dogs received Cytopoint injections per the US label every 4–8 weeks and returned on days 180 and 365 (+/- 7 days) after their initial Day 0 for examination by investigators. Pet owners were asked to complete an electronic PVAS assessment every 2 weeks. At each visit, investigators completed a Canine Atopic Dermatitis Extent and Severity Index (CADESI-4) score and VetVAS to measure skin lesion scores. There were 87% (64/75) of dogs who maintained a PVAS below their baseline PVAS on Day 0. Over the course of the study, 88% (65/75) of dogs obtained a mean PVAS below 36 mm. Of those dogs, 31% (23/75) achieved a biweekly PVAS that was below 36 for the entirety of the study with 11% (8/75) having a biweekly PVAS score that stayed below 20 (considered normal dog level of pruritus) for the entire study. Most owners (93%; 64/49) were satisfied with Cytopoint with 88% planning to continue Cytopoint usage. The majority (80%; 55/69) of pet owners reported they were able to reduce the use of other products while their dog was using Cytopoint, and 87% (60/69) of owners felt it was easier to care for the dog while using Cytopoint.
Global land drought hubs confounded by teleconnection hotspots in equatorial oceans
Authors: Ghosh Subimal , Chauhan Tejasvi , Chandel Vikram 
Published: August 2023

Abstract

Emerging data-driven techniques, such as Complex Networks (CNs), can identify spatial linkages between droughts on a global scale and, subsequently, drought propagation, which can improve early warning systems. Recent studies used CNs to identify hotspots of global drought teleconnections as land drought hubs; however, these studies excluded the ocean regions in CN, an oversight that can upend the insights gained thus far. Here, using a comprehensive global CN analysis on drought onsets, we show that oceanic regions harbor significantly larger drought hubs than land regions. The Indo-Pacific Warm pool (IPWP) in the Maritime continent emerges as the most significant drought hub having the farthest teleconnections. We show that IPWP, together with a few sub-tropical land and ocean regions, exhibit a ‘rich club phenomenon’ in CN. Further, using a causal network learning algorithm, we demonstrate the confounding role of oceans in modulating drought onsets on land regions indicating earlier studies might have overestimated the teleconnections of land drought hubs. Our study reveals novel insights on the spatiotemporal linkages of global drought onsets and highlights the role of oceans in driving global drought teleconnections and their potential role in drought propagation.
The evaluation of improved degradation of Acid Black ATT dye in aqueous solution by hybrid photo-ozonation peroxymonosulfate process
Authors: Majlesi Monireh , Rahmati Seyedeh Hoda , Alipour Arash , Dolatyari Atousa , Hashemi Marjan 
Published: August 2023

Abstract

The present study was designed and conducted to simultaneously produce two sulfate and hydroxyl radicals for the decomposition of Acid Black ATT dye, which showed that UV radiation and ozonation alone cannot decompose and break down this dye compound completely. The UV/O3/PMS process is able to completely remove all dye concentrations from 10 to 30 mg / L in 10 minutes. Then, the effect of parameters such as contact time, pH, initial dye concentrations, different doses of persulfate, and ozone under ultraviolet radiation on dye removal was studied. Based on the results of this experiment, the optimal concentrations of variables include pH, ozone concentration, and persulfate concentration, and initial dye concentration includes 10, 20 mg /min, 0.4 mM L− 1, and 20 mg/ L, respectively. For every 0.1 mM increase in PMS concentration, the amount of dye removal increased by 14%. Based on the findings of this study, the combined UV/O3/PMS process can be concluded that the environmentally friendly hybrid technology of advanced sulfate-based oxidation removes contaminants resistant to aqueous media.
Incidence and survival patterns of clear cell renal cell carcinoma from 2000 to 2017, based on A SEER Database
Authors: Liao Zhouning , Wang Dan , Zou Sijue , Zhang Yingying 
Published: August 2023

Abstract
Background:
Clear cell renal cell carcinoma (ccRCC) incidence and death have changed considerably in recent years. The purpose of our study was to investigate the incidence, survival, and tumor characteristics of ccRCC in the year of diagnosis and to compare their changes over time by using the Surveillance, Epidemiology, and End Results (SEER) database.
Materials and Methods:
Our study participants were drawn from the SEER database (2000-2017) and analyzed using SEER*Stat 8.4.1. Age-standardized incidence rates were calculated to compare incidence rates across time. In addition, we used Kaplan-Meier curves to calculate overall survival (OS) and Cox proportional hazards models to explore risk factors associated with mortality outcomes in patients with ccRCC.
Results:
In the SEER analysis from 2000 to 2017, we included a total of 101,892 patients with ccRCC. The increasing trend in age-adjusted incidence of ccRCC has remained relatively stable over the years, increasing from 2.63 per 100,000 in 2000 to 8.79 per 100,000 in 2017. The increase in the incidence of patients at a localized stage plays a decisive role in the overall increase in the incidence of ccRCC. In the general population, patients diagnosed in 2009-2017 had a higher survival rate (5-year OS rate = 73.45%) than those diagnosed in 2000-2008 (hazard ratio, HR: 0.89; 95% confidence interval, 95% CI: 0.88-0.91, P<0.001), which is consistent with all stages of the tumor.
Conclusions and Relevance:
The incidence of ccRCC increases steadily with the year of diagnosis, with the increase in patients with localized stages accounting for a major part of the increase. In addition, regardless of the stage of the disease, along with the increase in incidence, overall survival has significantly improved.
A Randomized Controlled Trial of a Fermented Soy Beverage Among Patients with Localized Prostate Cancer Prior to Radical Prostatectomy
Authors: Lokeshwar Soum D. , Ali Ather , Weiss Theresa R. , Reynolds Jesse , Shuch Brian M. , Ferencz Thomas , Kyriakides Tassos C. , Mehal Wajahat Z. , Brito Joseph , Renzulli Joseph , Leapman Michael S. 
Published: August 2023

Abstract

Background
Fermented soy products have shown to possess inhibitory effects on prostate cancer (PCa). We evaluated the effect of a fermented soy beverage (Q-Can®), containing medium-chain triglycerides, ketones and soy isoflavones, among men with localized PCa prior to radical prostatectomy.
Methods
We conducted a placebo-controlled, double-blind randomized trial of Q-Can®. Stratified randomization (Cancer of the Prostate Risk Assessment (CAPRA) score at diagnosis) was used to assign patients to receive Q-Can® or placebo for 2–5 weeks before RP. Primary endpoint was change in serum PSA from baseline to end-of-study. We assessed changes in other clinical and pathologic endpoints. The primary ITT analysis compared PSA at end-of-study between randomization arms using repeated measures linear mixed model incorporating baseline CAPRA risk strata.
Results
We randomized 19 patients, 16 were eligible for analysis of the primary outcome. Mean age at enrollment was 61, 9(56.2%) were classified as low and intermediate risk, and 7(43.8%) high CAPRA risk. Among patients who received Q-Can®, mean PSA at baseline and end-of-study was 8.98(standard deviation, SD 4.07) and 8.02ng/mL(SD 3.99) compared with 8.66(SD 2.71) to 9.53ng/mL(SD 3.03), respectively, (Difference baseline – end-of-study, p = 0.36). There were no significant differences in Gleason score, clinical stage, surgical margin status, or CAPRA score between treatment arms (p > 0.05), and no significant differences between treatment arms in end-of-study or change in lipids, testosterone and FACT-P scores (p > 0.05).
Conclusions
Short exposure to Q-Can® among patients with localized PCa was not associated with changes in PSA levels, PCa characteristics including grade and stage or serum testosterone. Due to early termination from inability to recruit, study power, was not achieved.
Trial Registration
ClinicalTrials.gov Identifier: NCT03532308, May 9, 2018
Possibility of Exciton Bose-Condensation in Cdse Nanoplatelets
Authors: Baghdasaryan Davit , Harutyunyan Volodya A. , Kazaryan Eduard M. , Sarkisyan Hayk A. , Petrosyan Lyudvig S. , Shahbazyan Tigran V. 
Published: August 2023

Abstract
The quasi-two-dimensional exciton subsystem in CdS nanoplatelets is considered. It is theoretically shown that Bose-Einstein condensation (BEC) of excitons is possible at a nonzero temperature in the approximation of an ideal Bose gas and in the presence of an “energy gap” between the ground and first excited states of two-dimensional exciton center of inertia of the translational motion. The condensation temperature (\({T_c}\)) increases with the width of the “gap” between the ground and the first excited levels of size quantization. It is shown that when the screening effect of free electrons and holes on bound excitons is considered, the BEC temperature of the exciton subsystem increases as compared to the case where this effect is absent. The energy spectrum of the exciton condensate in a CdS nanoplate is calculated within the framework of the weakly nonideal Bose gas approximation, considering the specifics of two-dimensional Born scattering.
Mastication and mobility limitations, sex differences, and biopsychosocial predictors of jaw functional limitations in Chinese patients with temporomandibular disorder
Authors: Fang Zhong-yi , Yang Yang , Liu Sha-sha , Liu Li-kun , Lu Shen-ji , Zeng Hong , Cai Bin , Xu Li-li 
Published: August 2023

Abstract
Objectives
To describe jaw function characteristics using the Chinese version of the Jaw Function Limitation Scale (JFLS) and to explore the impact of biopsychosocial risk factors on limitations in jaw function among Chinese patients with temporomandibular disorder (TMD).
Materials and Methods
This study included 488 Chinese patients with TMD. All patients completed the Chinese version of the JFLS; behavioral, psychometric, and self-report questionnaires; and clinical examinations.
Results
Limitations associated with TMD included restricted jaw mobility and mastication, both of which exceeded the median global functional limitations scale scores, particularly for opening the mouth to bite an apple and for chewing tough foods. Women reported greater jaw mobility and global limitations than men did. On multivariate logistic regression analysis, the diagnosis subgroup, pain intensity, oral behaviors, and anxiety were predictive of high limitations in jaw function. In the mediation analysis, oral behaviors and pain intensity mediated the relationship between anxiety and jaw function limitations.
Conclusions
Chinese patients with TMD principally reported restrictions in mastication and jaw mobility, with more pronounced limitations in women than men. The diagnosis subgroup, pain intensity, oral behaviors, and anxiety were significant predictors of limitations in jaw function. Anxiety not only significantly predicted jaw function limitations but also increased the degree of jaw function limitations by increasing oral behaviors and exacerbating pain.
Clinical Relevance:
Clinically, improving adverse emotional states, such as anxiety, could reduce oral behaviors and relieve painful symptoms, thereby improving limitations in jaw function, particularly in women.
Comparison of Decline In Different Cognitive Domain In Patients With Normal Pressure Hydrocephalus
Authors: Rýdlo Ondřej , Bubeníková Adéla , Häcklová Klára , Skalický Petr , Leško Robért , Ebel Adéla , Netuka David , IIIrd Vladimír Beneš , Beneš Vladimír , Bradáč Ondřej 
Published: August 2023

Abstract
Objectives
We sought to describe the cognitive profile of patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) using a comprehensive neuropsychological battery. Based on age and education correlated norms, we aimed to compare performance in each measured cognitive domain: executive functions (EFs), verbal memory (VM), non-verbal memory (nVM), visuospatial abilities (VA) and attention/psychomotor speed (A/PS).
Methods
Patients diagnosed with iNPH underwent comprehensive neuropsychological evaluation before shunting. Their performance was compared to the age and education correlated norms. Correlation of different cognitive domains in iNPH profile was performed.
Results
A total of 53 iNPH patients (73.21 ± 5.48 years) were included in the study. All of the measured cognitive domains were significantly damaged. The most affected domains were EFs and VM (p < 0.001 and p < 0.001, respectively). A/PS domain was affected milder than EFs and VM (p < 0.001). The least affected domains were nVM (p < 0.001) and VA (p < 0.001).
Conclusion
Patients with iNPH are affected in all cognitive domains and the cognitive decline is uneven across these domains. The impairment of memory was shown to depend on the presented material. VM was shown to be much more severely affected than nVM and along with VM, EFs were shown to be the most affected. A/PS speed was shown to be less affected than VM and EFs and the least affected domains were nVM and VA.
Catalytic performance of ZnO-Ce nanoparticles decorated on biochar derived from Milkvetch for photocatalytic removal of reactive blue 19 dye
Authors: Jahani Fatemeh , Maleki Basir , Mansouri Mohsen , Noorimotlagh Zahra , Mirzaee Seyed Abbas 
Published: August 2023

Abstract

In this work, the photocatalytic removal of reactive blue 19 (RB19) dye was investigated by employing ZnO-Ce nanoparticles decorated with biochar under LED irradiation. Synthesis of ZnO-Ce nanoparticles decorated with biochar was performed utilizing the co-precipitation procedure, and the texture and morphologyof the fabricated nanocomposite were analyzed using EDX, FESEM, XRD, TEM, BET, and FTIR techniques. Moreover, FESEM images demonstrated that ZnO-Ce nanoparticles were successfully decoratedon the surface of biochar. The specific surface areas of biochar and biochar@ZnO-Ce were 34.518 and 636.52 m2/g, respectively. To achieve the maximum yield in the removal of RB19 dye, the influence of operating variables including dye concentration, LED lamp power, biochar@ZnO-Ce catalyst dose, pH, and H2O2dose were explored. Besides, the maximum percentage of RB19 dye removal was 96.47% under optimal conditions, i.e. catalyst dosage of 100 mg, H2O2dosage of 1 mL, pH of 9, initial dye concentration of 5 ppm, LED power of 50 W, and reaction time of 140 min. Also, the kinetic information revealed that the removal of RB19 dye was in accordance with the pseudo-first order kinetic model, and the reaction rate constant and correlation coefficient were determined to be 0.045 min− 1and R2 = 0.990, respectively. Also, the recyclability of biochar@ZnO-Ce nanocatalysts was promising over five runs, and only 6.08% of RB19 dye removal efficiency decreased. Therefore, it can be concluded that the biochar@ZnO-Ce photocatalyst can be promisingly applied for the removal of azo dyes in the aqueous solutions.
A viral protein activates MAPKs pathway to promote viral infection by downregulating callose deposition in plants
Authors: Songbai Zhang , Feng Lixiao , Luo Xiangwen , Zhang Yu , Li Shijun , Zhang Zhanhong , Yang Xiao , Wang Xin , Ouyang Xian , Shi Xiaobin , Zhang Deyong , Tao Xiaorong , Chen Jianping , Yang Jian , Liu Yong 
Published: August 2023

AbstractMitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved in both plants and animals, playing critical roles in activating innate immunity to defend against various pathogens. However, the role of MAPK cascades in positively regulating or enhancing virus infections has not been extensively studied. In this study, we investigated the involvement of MAPK cascades in the infection of the positive-RNA virus, tomato chlorosis virus (ToCV), for the first time. Our findings reveal that ToCV infection activates MAPK cascades, promoting the virus spread within the plant. Specifically, ToCV P7, a pathogenicity determinant protein, localizes to the plasma membrane and recruits NbMPK3 from nucleus. Subsequently, P7 is directly phosphorylated on serine 59 by NbMPK3. The phosphorylated P7 then targets a remorin protein NbREM1, inhibiting callose deposition at plasmodesmata. These results demonstrate that conserved MAPK cascades directly phosphorylate viral proteins, modulating antiviral defense mechanisms by downregulating callose deposition at plasmodesmata and thereby enhancing virus transmission in plants. This study unveils molecular events associated with plasma membrane nanodomains and sheds light on the intricate arms race between host defense and viral counter-defense strategies.
A HS/SPME-GC×GC-TOF MS-Based Analysis of the Difference of Citri Grandis Exocarpium from Different Regions
Authors: Li Kaixuan , Wu Manman , Xu Jingwei , Luo Sifan , Luo Jianqun , Tan·Zhouzhen Guobin , Zhou zhen 
Published: August 2023

Abstract
In this study, a comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOF MS) combined with headspace solid-phase microextraction (HS/SPME) combined with chemometric was firstly used to analyze the volatile components of Citri Grandis Exocarpium that were from Huazhou (CGEH) and Guangxi (CGEG), respectively. The results from HS/SPME-GC×GC-TOF MS showed that total 304 chemicals among which 261 were firstly reported were identified. Among them 52 compounds were only detected in CGEH, 81 were unique in CGEG and 171 were in both CGEH and CGEG. The volatile components in CGEH were classified into 17 and CGEG into 19 types. The contents of alkene aromatics, hydrocarbons and alcohols in both CGEH and CGEG were relatively high. These results fully demonstrated the detection ability of GC×GC-TOF MS. Principal Component Analysis (PCA) and Orthogonal Partial Least Squares (OPLS-DA) were performed. The results indicated that there was basically no difference from different batches of the same origin. However, there were obvious differences between CGEH and CGEG. 10 compounds in CGEH were screened out the values of |p(corr)|>0.9, |p|>0.06 and VIP value > 1.1. These results could provide a helpful reference for the application of Citri Grandis Exocarpium.
A Guideline to Facilitate the Implementation of Collaborative Mdo in Conceptual Analysis of a Complex Product
Authors: Safavi Edris , Tarkian Mehdi , Ölvander Johan 
Published: August 2023

Abstract
This study provides a method to construct a collaborative multidisciplinary design optimization (CMDO) framework to be used in conceptual analysis of a complex engineering product. As its named implies, the CMDO framework, should be developed through the joint efforts of a team. Both technical and collaborative aspects should therefore be taken into account to provide a generic guideline. The proposed guideline to facilitate CMDO implementation in conceptual design is based on information gathered from a course project that included 40 students at Linköping University. An exploratory approach is used to clarify the technical/collaboration challenges, including questionnaires and extensive interviews with students. The guideline has been established to handle the challenges and difficulties of MDO implementation. It provides a handbook (step-by-step) approach to realize a CMDO framework in conceptual design. Preliminary results include an ontology to enable the use of CMDO, the collaboration strategy and a generic guideline.
Factor structure of callous unemotional traits and its associations with morality in middle childhood in a German community sample
Authors: Wilke Jessica , Eilts Jule , Bäker Neele , Rademacher Annika 
Published: August 2023

Abstract

The present study focuses on assessing the psychometric properties of the Inventory of Callous-Unemotional Traits (ICU) in a German community sample of middle childhood participants. Previous research on the ICU has primarily been conducted in different samples and countries, with inconsistent results and little attention given to German middle childhood populations. A total of 824 children aged 7 to 12 years (M = 10.34, SD = 1.65) participated (52.18% male). The ICU, a self-report measure, was employed to assess callous-unemotional traits in middle childhood. Additionally, this study also examines the relationship between callous-unemotional traits and morality. Confirmatory factor analyses were conducted to evaluate various model structures based on previous research. The best-fitting model was found to be a two-factor model consisting of callousness and uncaring factors. The moral self shows a stronger overarching association with the uncaring factor than with callousness.
The Surgical Outcome and Prognostic Factors for Solitary Colorectal Liver Metastasis
Authors: Hsu Yu-Jen , Chern Yih-Jong , Wu Zhong-En , Yu Yen-Lin , Liao Chun-Kai , Tsai Wen-Sy , You Jeng-Fu , Lee Chao-Wei 
Published: August 2023

Abstract
Background:
The study focused on patients who had surgery for solitary liver metastasis of colorectal cancer (CRLM) and experienced relapse. Its main objective was to analyze the factors that independently contribute to recurrence and long-term overall survival.
Methods:
We retrospectively analyzed 230 solitary CRLM patients who received liver resection between 2010 and 2019. Factors prognostic of disease recurrence and overall survival were investigated and nomograms were developed to predict patient outcome after liver resection.
Results:
For these patients, the 3-year-overall survival (OS) rate was 72.3% and 59.8% for 5-years. For the recurrence-free survival (RFS) rate, it was 40.0% for 3-years and 27.1% for 5-years. The multivariate analysis showed that age ≥ 70, resection margin width < 10 mm, initial N2 stage, hypoalbuminemia before liver resection, and neutrophil-lymphocyte ratio (NLR) ≥ 3 after liver resection were independent prognostic factors for OS. For RFS, the multivariate analysis showed that initial N2 stage, hypoalbuminemia before liver resection, NLR ≥ 3 after liver resection, abnormal Carcinoembryonic antigen (CEA) after liver resection, and CEA ratio (after/before liver resection) < 0.3 were independent prognostic factors.
Conclusions:
The study found that several factors significantly impact both the recurrence and overall survival rates of patients who had surgery for solitary liver metastasis of colorectal cancer. The most important risk factors identified were the initial N2 stage, a neutrophil-lymphocyte ratio of 3 or higher after liver resection, and hypoalbuminemia (albumin levels below 3.5 g/dL) before liver resection.