bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hydrolyzed lipid blend diet promotes myelination in neonatal piglets in a region and concentration‐dependent manner
Authors: Louie Allison Y. , Rund Laurie A. , Komiyama‐Kasai Karin A. , Weisenberger Kelsie E. , Stanke Kayla L. , Larsen Ryan J. , Leyshon Brian J. , Kuchan Matthew J. , Das Tapas , Steelman Andrew J. 
Published: September 2023

AbstractThe impact of early life nutrition on myelin development is of interest given that cognitive and behavioral function depends on proper myelination. Evidence shows that myelination can be altered by dietary lipid, but most of these studies have been performed in the context of disease or impairment. Here, we assessed the effects of lipid blends containing various levels of a hydrolyzed fat (HF) system on myelination in healthy piglets. Piglets were sow‐reared, fed a control diet, or a diet containing 12%, 25%, or 53% HF consisting of cholesterol, fatty acids, monoglycerides, and phospholipid from lecithin. At postnatal day 28/29, magnetic resonance imaging (MRI) was performed to assess changes to brain development, followed by brain collection for microscopic analyses of myelin in targeted regions using CLARITY tissue clearing, immunohistochemistry, and electron microscopy techniques. Sow‐reared piglets exhibited the highest overall brain white matter volume by MRI. However, a 25% HF diet resulted in the greatest total myelin density in the prefrontal cortex based on 3D modeling analysis of myelinated filaments. Nodal gap length and g‐ratio were inversely correlated with percentage of HF in the corpus callosum, as well as in the PFC and internal capsule for g‐ratio, indicating that a 53% HF diet resulted in the thickest myelin per axon and a 0% HF control diet the thinnest in specific brain regions. These findings indicate that HF promoted myelination in the neonatal piglet in a region‐ and concentration‐dependent manner.
A 1500‐year record of North Atlantic storm flooding from lacustrine sediments, Shetland Islands (UK)
Authors: Hess Katharina , Engel Max , Patel Tasnim , Vakhrameeva Polina , Koutsodendris Andreas , Klemt Eckehard , Hansteen Thor H. , Kempf Philipp , Dawson Sue , Schön Isa , Heyvaert Vanessa M. A. 
Published: September 2023

ABSTRACTSevere storm flooding poses a major hazard to the coasts of north‐western Europe. However, the long‐term recurrence patterns of extreme coastal flooding and their governing factors are poorly understood. Therefore, high‐resolution sedimentary records of past North Atlantic storm flooding are required. This multi‐proxy study reconstructs storm‐induced overwash processes from coastal lake sediments on the Shetland Islands using grain‐size and geochemical data, and the re‐analysis of historical data. The chronostratigraphy is based on Bayesian age–depth modelling using accelerator mass spectrometry 14C and 137Cs data. A high XRF‐based Si/Ti ratio and the unimodal grain‐size distribution link the sand layers to the beach and thus storm‐induced overwash events. Periods with more frequent storm flooding occurred 980–1050, 1150–1300, 1450–1550, 1820–1900 and 1950–2000 ce, which is largely consistent with a positive North Atlantic Oscillation mode. The Little Ice Age (1400–1850 ce) shows a gap of major sand layers suggesting a southward shift of storm tracks and a seasonal variance with more storm floods in spring and autumn. Warmer phases shifted winter storm tracks towards the north‐east Atlantic, indicating a possible trend for future storm‐track changes and increased storm flooding in the northern North Sea region.
Separation and purification of alkaloids and phenolic acids from Phellodendron chinense by pH‐zone refining and online‐storage inner‐recycling counter‐current chromatography
Authors: Zhu Heng , Geng Yanling , Ding Shangzhi , Li Enxia , Li Lili , Wang Xiao , Yu Jinqian 
Published: September 2023

In this work, eight compounds from Phellodendron chinense were separated and purified by pH‐zone refining counter‐current chromatography and traditional counter‐current chromatography coupled with online‐storage inner‐recycling counter‐current chromatography (IRCCC). The pH‐zone‐refining mode was adopted for separating 2.0 g of crude extract with the solvent system of chloroform–methanol–water (4:3:3, v/v), in which 10 mM hydrochloric acid and 10 mM triethylamine were added in the stationary and mobile phases, respectively. Meanwhile, traditional counter‐current chromatography coupled with online‐storage IRCCC separation was performed by the solvent system of n‐hexane‐ethyl acetate‐methanol‐water (5:5:2:8, v/v). Finally, eight compounds, including six alkaloids as 6‐methylpiperidin‐2‐one(1), isoplatydesmine(4), berlambine(5), epiberberine(6), palmatine(7), berberine(8) and two phenolic acids as ferulic acid(2), isoferulic acid(3), were successfully obtained using these three different CCC modes with the purities over 95.0%.
A New Era of Modeling MOF‐Based Membranes: Cooperation of Theory and Data Science
Authors: Demir Hakan , Keskin Seda 
Published: September 2023

AbstractMembrane‐based separation can offer significant energy savings over conventional separation methods. Given their highly customizable and porous structures, metal–organic frameworks‐ (MOFs) are considered as next‐generation membrane materials that can bring about high separation performance and energy efficiency in various separation applications. Yet, the enormously large number of possible MOF structures necessitates the development and implementation of efficient modeling approaches to expedite the design, discovery, and selection of optimal MOF‐based membranes via directing the experimental efforts, time, and resources to the potentially useful membrane materials. With the recent developments in the field of atomic simulations and artificial intelligence methods, a new era of membrane modeling has started. This review focuses on the recent advances made and key strategies used in the modeling of MOF‐based membranes and highlight the huge potential of combining atomistic modeling of MOFs with machine learning to explore very large number of MOF membranes and MOF/polymer composite membranes for gas separation. Opportunities and challenges related to the implementation of data‐driven approaches to extract useful structure–property relations of MOF‐based membranes and to produce design principles for the high‐performing MOF‐based membranes are discussed.
CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c‐Raf/p‐MEK/p‐ERK signaling loop
Authors: Zhang Xiujuan , Zhao Yu , Yiminniyaze Ruzetuoheti , Zhu Ning , Zhang Yuanyuan , Wumaier Gulinuer , Xia Jingwen , Dong Liang , Zhou Daibing , Wang Jing , Li Chengwei , Zhang Youzhi , Li Shengqing 
Published: September 2023

AbstractThe repertoire of aberrant signaling underlying the pathogenesis of lung adenocarcinoma remains largely uncharacterized, which precludes an efficient therapy for these patients, especially when distant metastasis occurs. Cyclin‐dependent kinase 10 (CDK10) has been reported to modulate the progression of malignant tumors; however, contradictory effects have been found among different types of malignant tumors. In the present study, we found that CDK10 was downregulated in lung adenocarcinoma compared with the paired adjacent normal lung tissue, and lower expression level of CDK10 was associated with more frequent N2 staged lymph node and distant metastasis, higher TNM stage, and shorter overall survival. Further study indicated that CDK10 inhibited the migration and invasion abilities with no impact on the proliferation of lung adenocarcinoma cells. Mechanistically, CDK10 could bind to and promote the degradation of ETS2, a transcription factor for C‐RAF and MMP2/9, thereby inactivating the downstream c‐Raf/p‐MEK/p‐ERK pathway that drives epithelial–mesenchymal transition and impairing the expression of matrix metalloproteinases involved in cell invasion. In addition, the p‐MEK/p‐ERK pathway conducts a positive feedback regulation on the expression of ETS2. Knockdown of CDK10 in human lung adenocarcinoma cells significantly promoted the formation of metastatic foci in lungs in a xenograft mouse model. In conclusion, CDK10 suppresses metastasis of lung adenocarcinoma by disrupting the ETS2/c‐Raf/p‐MEK/p‐ERK/ETS2 signaling and MMP2/9, providing a new therapeutic target for the treatment of lung adenocarcinoma with metastasis.
A family of inertial‐based derivative‐free projection methods with a correction step for constrained nonlinear equations and their applications
Authors: Liu Pengjie , Shao Hu , Yuan Zihang , Zhou Jianhao 
Published: September 2023

AbstractNumerous attempts have been made to develop efficient methods for solving the system of constrained nonlinear equations due to its widespread use in diverse engineering applications. In this article, we present a family of inertial‐based derivative‐free projection methods with a correction step for solving such system, in which the selection of the derivative‐free search direction is flexible. This family does not require the computation of corresponding Jacobian matrix or approximate matrix at every iteration and possess the following theoretical properties: (i) the inertial‐based corrected direction framework always automatically satisfies the sufficient descent and trust region properties without specific search directions, and is independent of any line search; (ii) the global convergence of the proposed family is proven under a weaker monotonicity condition on the mapping , without the typical monotonicity or pseudo‐monotonicity assumption; (iii) the results about convergence rate of the proposed family are established under slightly stronger assumptions. Furthermore, we propose two effective inertial‐based derivative‐free projection methods, each embedding a specific search direction into the proposed family. We present preliminary numerical experiments on certain test problems to demonstrate the effectiveness and superiority of the proposed methods in comparison with existing ones. Additionally, we utilize these methods for solving sparse signal restorations and image restorations in compressive sensing applications.
A new analytical approach to the nonlinear buckling and postbuckling behavior of functionally graded graphene reinforced composite laminated cylindrical, parabolic, and half‐sinusoid shallow imperfect panels
Authors: Nam Vu Hoai , Van Doan Cao , Phuong Nguyen Thi 
Published: September 2023

AbstractThis paper presents and analyzes the nonlinear buckling responses of three types of shallow imperfect panels (cylindrical panel, parabolic panel, and half‐sinusoid panel) made from functionally graded graphene reinforced composite (FG‐GRC) on nonlinear elastic foundations subjected to axial compressive load in thermal environments. The nonlinear governing equations are formulated on Reddy's higher‐order shear deformation shell theory (HSDST) and take into account von Karman‐type nonlinearity. A new approximation technique to determine the stress function in average sense is developed and Galerkin's method is used to obtain the algebraically nonlinear equation system. Then, the simple calculation process can be used to solve the obtained equation systems, and the formulations to calculate the critical buckling loads and postbuckling load‐deflection curves are expressed in explicit form. The results can be flexibly applied to FG‐GRC panels with different curvatures in engineering designs. The effects of panel types, geometrical parameters, temperature increase, initial imperfection, and nonlinear elastic foundations on the critical buckling loads and postbuckling curves of cylindrical, parabolic, and half‐sinusoid FG‐GRC panels are discussed in numerical results. Numerical results also show a small disadvantage in the load‐carrying capacity of cylindrical panels compared to parabolic panels and half‐sinusoid shallow panels.Highlights
Postbuckling of cylindrical, parabolic, and half‐sinusoid panels are studied.
The panels are made of functionally graded graphene reinforced composite.
Reddy's higher‐order shear deformation shell theory is applied.
A new approximation technique to determine the stress function is developed.
Critical buckling loads and postbuckling expressions are explicitly obtained.
Effects of process parameters on mechanical properties and interface of 3D printed bamboo‐inspired CCFR‐PLA/TPU composites
Authors: Ye Wenguang , Dou Hao , Zhang Dinghua , Yang Fuqiang , Cheng Yunyong , Cai Wenfeng 
Published: September 2023

AbstractInspired by the exceptional strength and toughness of fresh bamboo, a low‐cost method for preparing continuous fiber‐reinforced multi‐matrix composites based on 3D printing was proposed in this paper. Through the design of a special extrusion nozzle, the controllable feed of polylactic‐acid (PLA) and thermoplastic polyurethane (TPU) filaments was achieved, allowing for the preparation of continuous carbon fiber reinforced PLA/TPU composites. The effects of various process parameters on the tensile and flexural properties of the CCFR‐PLA/TPU composites were investigated. Additionally, the relationship between process parameters and the formation of the matrix‐fiber interface and PLA‐TPU interface was analyzed. The results show that layer height has the greatest influence on mechanical properties, while the printing speed has the least influence. The mechanical properties of the CCFR‐PLA/TPU composites and the unreinforced blend matrix, prepared using the optimal combination of process parameters, were tested. The results demonstrated that the tensile strength and flexural strength of the CCFR‐PLA/TPU composites increased by 16.95 and 1.80 times, respectively, compared to the unreinforced blend matrix. Further, inspired by the overall structure of bamboo, a stiffness gradient CCFR composite material was designed and prepared. The methodology employed in this study holds significant implications for the advancement of novel multi‐matrix hybrid continuous fiber reinforced composites, particularly in aerospace and related industries.Highlights
Multi‐matrix continuous fiber reinforced composites were prepared by 3D printing inspired by fresh bamboo.
The effects of process parameters (nozzle temperature, printing speed, extrusion width, layer height) on mechanical properties were investigated.
The optimal printing parameter combination was determined by range analysis.
Stiffness gradient composites were prepared inspired by the overall structure of bamboo.
The epidemiologic trend of respiratory syncytial virus has returned strongly to its origin after the pandemic: Five‐year data from a single center
Authors: Çağlar Hanife Tuğçe , Pekcan Sevgi , Yılmaz Aslı İmran , Ünal Gökçen , Ercan Fatih , Savaş Suat , Akcan Özge Metin , Ünsaçar Mahmut Ziya , Ünsaçar Kübra , Özdemir Mehmet 
Published: September 2023

AbstractObjectiveOnly a few studies have investigated the frequency and severity of respiratory syncytial virus (RSV) infections after the end of the pandemic regulations. This study aims to investigate the frequency and severity of RSV infections before, during, and after the pandemic in Turkey.Materials and MethodsPatients under 18 years of age and those who tested positive for RSV between April 2018 and March 2023 were retrospectively reviewed. All patients were divided into three groups (pre‐COVID‐19, COVID‐19, and post‐COVID‐19) according to admission date. Among inpatients, data were compared between the three groups to determine the impact of the pandemic on RSV epidemiology and clinical outcomes.ResultsA total of 9567 patients were tested for RSV, of which 1073 (11.2%) were positive and included in the study. Hospitalization occurred in 447 (41.7%) patients. Inpatients were younger than outpatients (p < .000). Among the three inpatient pandemic groups, clinical outcomes were statistically significantly worse in the post‐COVID‐19 group than in the other two groups. SpO2 was lower (p < .000), inhaled salbutamol requirement was higher (p < .000), length of stay was longer (p = .031), and ICU admission was higher (p = .023).ConclusionAlthough the RSV trend changed within 2 years after the COVID‐19 outbreak, it returned to its usual seasonality last year. After the repeal of all COVID‐19 measures and the normal life began, the number of RSV‐positive patients and RSV‐related hospitalizations increased, and the clinical outcomes of RSV worsened. This may be a result of decreased herd immunity due to a change in society's attitude toward epidemic diseases.
Synthesis, acaricidal activity, and structure–activity relationships of novel phenyl trifluoroethyl thioether derivatives containing substituted benzyl groups
Authors: Liu Dongdong , Zhang Jing , Gao Yixing , Hao Haijing , Zhang Chenyang , Wang Feng , Zhang Lixin 
Published: September 2023

AbstractBACKGROUNDTo discover and develop novel acaricidal compounds, a series of 2‐fluoro‐4‐methyl/chlorine‐5‐((2,2,2‐trifluoroethyl)thio)aniline/phenol compounds containing N/O‐benzyl moieties were synthesized based on lead compound LZ‐1.RESULTSThe activity of these compounds against carmine spider mites (Tetranychus cinnabarinus) was determined using the leaf‐spray method. Bioassays indicated that most of the designed target compounds possessed moderate to excellent acaricidal activity against adult T. cinnabarinus. The median lethal concentrations of 25b and 26b were 0.683 and 2.448 mg L−1 against adult mites, respectively; exceeding those of bifenazate (7.519 mg L−1) and lead compound LZ‐1(3.658 mg L−1). Compound 25b exhibited 100% mortality in T. cinnabarinus larvae at 10 mg L−1.CONCLUSIONContinuing the study of these compounds in field trials, we compared the efficacy of mite killing by compound 25b with the commercial pesticide spirodiclofen and showed that mite control achieved 95.9% and 83.0% lethality at 10 and 22 days post‐treatment. In comparison, spirodiclofen showed 92.7% lethality at 10 days and 77.2% lethality at 22 days post‐treatment at a concentration of 100 mg L−1. Results showed that 25b produced more facile and long‐lasting control against T. cinnabarinus than the commercial acaricide spirodiclofen. Density functional theory analysis and electrostatic potential calculations of various molecular substitutions suggested some useful models to achieve other highly active miticidal compounds. © 2023 Society of Chemical Industry.
Millimeter‐Scale Temperature Self‐Calibrated Diamond‐Based Quantum Sensor for High‐Precision Current Sensing
Authors: Liu Qihui , Xie Fei , Peng Xiao , Hu Yuqiang , Wang Nan , Zhang Yonggui , Wang Yang , Li Lingyun , Chen Hao , Cheng Jiangong , Wu Zhenyu 
Published: September 2023

AbstractThe negatively charged nitrogen vacancy (NV) color center in diamond is a type of point defect, which is extensively studied as a promising high‐sensitivity solid‐state magnetic field sensor. However, its transition from research to application is still limited due to the technical challenges of an integrated physical package. Here, an integrated diamond sensor is demonstrated with the essential component on the order of mm3, which is realized by a standard microfabrication process. A microfabrication‐compatible light guiding structure is constructed, providing photon detection efficiency of 66% and thus enabling a magnetic field detection sensitivity reaching 203 pT·Hz1/2. Incorporation of the sensor device with a magnetic yoke enables high‐precision wide‐range direct‐current sensing with current isolation. A current measuring range of 0–400 A with a minimum detection limit of 2 mA is achieved. By utilizing dual spin resonance modulation, the temperature drift is suppressed from 219 to 1.92 ppm∙°C−1. This configuration provides new possibilities as a robust and scalable platform for current quantum sensing technologies.
Constraining the output of discrete‐time systems using sliding mode control with a novel sliding hyperplane
Authors: Latosinski Pawel , Bartoszewicz Andrzej 
Published: September 2023

AbstractSliding mode control strategies are widely applicable to systems subject to disturbance and modeling uncertainties. However, since sliding mode controllers are typically only concerned with the evolution of a virtual sliding variable, potential state constraints placed on the system are often neglected when applying such strategies. Motivated by this problem, in this article, we propose a novel sliding mode control strategy for discrete‐time systems with the aim of satisfying constraints placed on their output. The proposed approach uses a new sliding hyperplane designed to ensure a linear relationship between the sliding variable and the system output. The main contribution of the article involves demonstrating that when using this approach, one can indirectly impose bounds on the output rate of change by limiting the convergence rate of the sliding variable to zero. The obtained result has been documented for two cases. In the first part of the article, the proposed approach has been applied to systems with full state information always known. Then, the strategy has been extended to plants with only output signal available, where the full state needs to be estimated.
Study on the coordination of flow and sediment transport, ecological environment, and crop production in the Lower Yellow River since 2000
Authors: Jiang Enhui , Qu Bo , Jia Jia , Liu Chang , Wang Yuanjian , Li Donglin , Li Jieyu 
Published: September 2023

AbstractThe Xiaolangdi Reservoir has been operated for 23 consecutive years, greatly altering the flow and sediment processes of the Lower Yellow River. Many research have separately analyzed the changes of siltation in reservoirs and river channels, discharge capacity of the lower river channel, river regime stability, or ecological environmental benefits under water and sediment regulation. However, the multiple changes of flow and sediment transport, ecological environment, and social economy were seldom considered. We systematically and holistically explored the changes of river system in the Lower Yellow River since 2000, based on the channel erosion and siltation, channel morphology, ecosystem patterns and habitat quality, irrigation water scale, and crop production index. The results show that the discharge capacity of the main channel has been recovered significantly at a bankfull discharge of over 4700 m3/s. The ecological pattern in the Lower Yellow River and the delta has been optimized. The wetland and water ecosystem area has been remarkably increased by 125.82% and 318.54% respectively, and the saline‐alkali land area has been sharply reduced by 89.65%. The habitat quality has been raised to the highest level in nearly 40 years. The irrigation water volume in the irrigation area of the Lower Yellow River has been increased by 31%, and the grain production has maintained a continuous growth for 16 years. Overall, the coordinated development level of flow and sediment transport, ecological environment and crop production in the Lower Yellow River has been continuously improved from the reluctantly coordinated level (before water and sediment regulation) to the highly coordinated level.