bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile phone calls, genetic susceptibility, and new-onset hypertension: results from 212 046 UK Biobank participants
Authors: Ye Ziliang , Zhang Yanjun , Zhang Yuanyuan , Yang Sisi , Liu Mengyi , Wu Qimeng , Zhou Chun , He Panpan , Gan Xiaoqin , Qin Xianhui 
Published: May 2023

Abstract

Aims
The relationship between mobile phone use for making or receiving calls and hypertension risk remains uncertain. We aimed to examine the associations of mobile phone use for making or receiving calls and the use frequency with new-onset hypertension in the general population, using data from the UK Biobank.

Methods and results
A total of 212 046 participants without prior hypertension in the UK Biobank were included. Participants who have been using a mobile phone at least once per week to make or receive calls were defined as mobile phone users. The primary outcome was new-onset hypertension. During a median follow-up of 12.0 years, 13 984 participants developed new-onset hypertension. Compared with mobile phone non-users, a significantly higher risk of new-onset hypertension was found in mobile phone users [hazards ratio (HR), 1.07; 95% confidence interval (CI): 1.01–1.12]. Among mobile phone users, compared with those with a weekly usage time of mobile phones for making or receiving calls &lt;5 mins, significantly higher risks of new-onset hypertension were found in participants with a weekly usage time of 30–59 mins (HR, 1.08; 95%CI: 1.01–1.16), 1–3 h (HR, 1.13; 95%CI: 1.06–1.22), 4–6 h (HR, 1.16; 95%CI: 1.04–1.29), and &gt;6 h (HR, 1.25; 95%CI: 1.13–1.39) (P for trend &lt;0.001). Moreover, participants with both high genetic risks of hypertension and longer weekly usage time of mobile phones making or receiving calls had the highest risk of new-onset hypertension.

Conclusions
Mobile phone use for making or receiving calls was significantly associated with a higher risk of new-onset hypertension, especially among high-frequency users.
Trajectories of Physical Function and Behavioral, Psychological, and Social Well-Being in a Cohort of Swedish Older Adults
Authors: Saadeh Marguerita , Xia Xin , Verspoor Eline , Welmer Anna-Karin , Dekhtyar Serhiy , Vetrano Davide L , Fratiglioni Laura , Melis René J F , Calderón-Larrañaga Amaia 
Published: May 2023

Abstract

Background and Objectives
Successful aging has been described as a multifactorial and dynamic process. The aims of the study were to detect aging trajectories of physical function and behavioral, psychological, and social well-being; and to explore the correlations between functional versus well-being trajectories by age group.

Research Design and Methods
Data were gathered from the Swedish National Study on Aging and Care in Kungsholmen (N = 1,375). Subjects’ physical function was assessed through walking speed and chair-stand tests, behavioral well-being through participation in mental and physical activities, psychological well-being through life satisfaction and positive affect, and social well-being through social connections and support. All exposures were standardized (z-scores). Linear mixed models were used to estimate trajectories of physical function and well-being over a 12-year follow-up.

Results
The steepest declines were seen for physical function (relative change [RC] in z-scores across ages; RC = 3.01), followed by behavioral well-being (RC = 2.15), psychological well-being (RC = 2.01), and social well-being (RC = 0.76). Correlations between physical function and the different well-being domains were weak, especially for slopes. Stronger intercept correlations were observed among the oldest—compared to the youngest-old, especially with behavioral (r = 0.39 vs r = 0.24) and psychological (r = 0.33 vs r = 0.22) well-being.

Discussion and Implications
Physical function declines the fastest throughout aging. The different well-being domains decline at a slower rate, which may be a possible sign of compensation against age-related functional decline, especially among the youngest-old, for whom discordances between physical function and the different well-being domains were more common.
Misinformation messages shared via WhatsApp in Mexico during the COVID-19 pandemic: an exploratory study
Authors: Wirtz Veronika J , Millán-Garduño Gabriel , Hegewisch-Taylor Jennifer , Dreser Anahi , Anaya-Sanchez Andrea , González-Vázquez Tonatiuh T , Escalera Ricardo , Torres-Pereda Pilar 
Published: May 2023

Abstract
Little is known about the role of WhatsApp in spreading misinformation during the start of the COVID-19 pandemic in Mexico. The aim of this study is to analyze the message content, format, authorship, time trends and social media distribution channels of misinformation in WhatsApp messages in Mexico. From March 18 to June 30, 2020 the authors collected all WhatsApp messages received via their personal contacts and their social networks that contained information about COVID-19. Descriptive and inferential statistics were used to analyze the scientifically inaccurate messages and the relationship between variables, respectively. Google image and video searches were carried out to identify sharing on other social media. Out of a total of 106 messages, the most frequently mentioned COVID-19 related message topics were prevention (20.0%), conspiracy (18.5%), therapy (15.4%) and origin of the virus (10.3%), changing throughout the pandemic according to users’ concerns. Half of all WhatsApp messages were either images or videos. WhatsApp images were also shared on Facebook (80%) and YouTube (~50%). Our findings indicate that the design of information and health promotion campaigns requires to be proactive in adapting to the changes in message content and format of misinformation shared through encrypted social media.
AACC Guidance Document on the Clinical Use of Procalcitonin
Authors: Chambliss Allison B , Patel Khushbu , Colón-Franco Jessica M , Hayden Joshua , Katz Sophie E , Minejima Emi , Woodworth Alison 
Published: May 2023

Abstract

Background
Procalcitonin (PCT), a peptide precursor of the hormone calcitonin, is a biomarker whose serum concentrations are elevated in response to systemic inflammation caused by bacterial infection and sepsis. Clinical adoption of PCT in the United States has only recently gained traction with an increasing number of Food and Drug Administration–approved assays and expanded indications for use. There is interest in the use of PCT as an outcomes predictor as well as an antibiotic stewardship tool. However, PCT has limitations in specificity, and conclusions surrounding its utility have been mixed. Further, there is a lack of consensus regarding appropriate timing of measurements and interpretation of results. There is also a lack of method harmonization for PCT assays, and questions remain regarding whether the same clinical decision points may be used across different methods.

Content
This guidance document aims to address key questions related to the use of PCT to manage adult, pediatric, and neonatal patients with suspected sepsis and/or bacterial infections, particularly respiratory infections. The document explores the evidence for PCT utility for antimicrobial therapy decisions and outcomes prediction. Additionally, the document discusses analytical and preanalytical considerations for PCT analysis and confounding factors that may affect the interpretation of PCT results.

Summary
While PCT has been studied widely in various clinical settings, there is considerable variability in study designs and study populations. Evidence to support the use of PCT to guide antibiotic cessation is compelling in the critically ill and in some lower respiratory tract infections but is lacking in other clinical scenarios, and evidence is also limited in the pediatric and neonatal populations. Interpretation of PCT results requires guidance from multidisciplinary care teams of clinicians, pharmacists, and clinical laboratorians.
181 Effect of Temperature and Humidity on Daily Feeding Behavior in Swine
Authors: Peppmeier Zack , Leonard Suzanne M , Knauer Mark 
Published: May 2023

Abstract
Heat stress has negative impacts on pork production, particularly during the grow-finish phase. During heat stress events, swine alter feeding behavior to reduce heat production, which can negatively affect performance. Recent technology advancements in feed management systems allow for individualized data recording of feeding behavior for group housed pigs during the finishing phase. The objective of this study was to utilize an RFID-based feed management system to determine feeding behavior patterns of finishing pigs during heat stress conditions and identify changes in behavior due to heat stress events. Data included one pen of 29 Duroc boars reared in a mechanically ventilated facility in north central North Carolina. Feed Intake Recording Equipment (FIRE) pig feeders (n = 3; Osborne Technologies) fed individual pigs in the group housed setting using RFID technology and recorded the number of visits, feed intake of each visit, visit duration, and body weight of each pig during each visit. Feeders were calibrated once per week to ensure accuracy of feed intake and body weight measurements. On day 1 of the study, pigs were placed in the experimental pen and body weights were recorded (37.4 kg ± 4.9 kg) using the FIRE feeders. Air temperature, humidity, and dew point data were collected continuously every 5 minutes from day 13 until the end of the finishing period. Pigs exited finishing (134.5 ± 8.6 kg) on day 83. Feeding behavior traits (number of visits and feed intake) were summarized by day. Temperature, humidity, and heat index were summarized by a maximum, minimum, and mean value for each day. Average temperature, humidity, feeder visits a day, and average daily feed intake across the trial was 26.3 ± 1.6 º C, 75.8 ± 6.7%, 6.1 ± 1.0 visits, 2.66 ± 0.39 kg. Models were used to associate feeding behavior traits with the quadratic effects of day and the linear effects of average temperature and humidity and the interaction of temperature and humidity. Temperature and humidity were associated (P &lt; 0.01) number of feeder visits and average daily intake per day. Further, there was an interaction (P &lt; 0.01) between temperature and humidity in relation to number of feeder visits and average daily feed intake. Results suggest substantial variation in feeding behaviors can be explained by temperature and humidity.
182 North Carolina Small Ruminant Improvement Program Workshops Build Producer Knowledge of Important Management Techniques
Authors: Rogers Johnny R , Weaver Andrew R , Cope Emily 
Published: May 2023

Abstract
Growing interest in small ruminant production, strong market demand, and producers’ minimal use of data-driven management practices led to the development of the North Carolina Small Ruminant Improvement Program (NCSRIP) in 2021. This program seeks to improve the number and quality of small ruminants produced in North Carolina as well as improve producer profitability. Three workshops were held to increase producer awareness of new small ruminant production practices and opportunities. All workshops included classroom and breakout sessions featuring hands-on activities. In February 2022, the Lambing and Kidding Workshop was held in cooperation with NC Sheep Producers Association at the North Carolina State Small Ruminant Educational Unit (Raleigh, NC). Topics included pre-lambing/kidding management, lambing and kidding diseases, the birthing process, dystocia management and lamb/kid processing. The Flock Management Workshop was held in May on a working sheep farm near Dobson, NC. Attendees learned about hay sampling and analysis, ration balancing, flock health management and cost share resources for small ruminant operations. In June, the NCSRIP joined with the Eastern Alliance for Production Katahdins to host a grazing school in Roxboro, NC. The agenda featured predator regulatory considerations, herding dog use, parasite management, genetic selection, soil health and pasture management. Workshop pre-registrations were 162 with 65 attending the events with 63 evaluations completed. Fifty-six percent of participants owned 1-50 breeding females. Twenty-seven percent of participants had no livestock but were gathering information for future endeavors. Fifty-seven percent of operations owned sheep, 13.0% raised goats, 7.4% produced cattle and 22.4% grazed combinations of all species. Fifty-seven percent of producers lived in the North Carolina Piedmont region while 14.3% resided in the Coastal region, 2.9% from the Mountain region and 25.7% from out of state. Post-workshop evaluations asked attendees to rank their increased understanding of each major agenda topic. On a scale of 1 to 5 (1 = no improvement to 5 = significant improvement), participants indicated they had improvement in all topics (mean = 4.18). When asked about participating in future NCSRIP events, producers suggested they would attend (mean = 4.62; 1 = will not participate to 5 = will attend if possible). When asked about what they like most about these workshops, attendees mentioned the hands-on approach and practical knowledge gained. Producer feedback indicates a growing interest in small ruminant production and a need for continued practical education programs.
14 Mitigation Strategies for Heifer Development on ‘KY-31’ Tall Fescue
Authors: Boone Madison L , Carrell Russell C , Fuller Rush , Dillard Leanne L 
Published: May 2023

Abstract
Tall fescue (Schedonorus arundinaceus) is the predominant cool-season perennial forage in the Eastern U.S. However, a symbiotic endophyte reduces performance of animals grazing tall fescue. This results in losses of around $2 billion annually. Due to the vasoconstriction caused by the endophyte, a decrease in conception rates among cows and heifers consuming tall fescue has been observed. With rising input costs, it is necessary to explore alternative mitigation strategies these production losses. The objective of this study was to mitigate the toxic effects of ‘KY 31’ tall fescue by limit-grazing cool-season annuals as an alternative to feed supplementation. In January 2022, 48 heifers [14 months of age; 365.9 ± 11.89 kg body weight (BW)] were randomly assigned to tall fescue only, tall fescue with supplemental feed at 1% of BW, tall fescue with limit grazing of cool-season annuals for 24 h per week, and cool-season annuals only. Four animals grazed in each of three replicated paddocks per treatment. Cool-season annual pasture was a mixture of crimson clover (Trifolium incarnatum), annual ryegrass (Lolium multiflorum), and oat (Avena sativa). Body condition scores (BCS), hair coat scores (HCS), and BW were recorded every 30 d. Forage samples were taken for biomass, nutritive value, and ergovaline concentration every 30 d. On April 1, 2022, heifers were artificially inseminated (AI), and conception rates were determined 45 d after AI. Data were analyzed using the Glimmix procedure of SAS 9.4 (SAS Inst, Cary, NC) with α = 0.05. There were no differences among treatments in HCS at any weigh date (P &gt; 0.05). The BCS for all treatments was less in February than January or March (5.6, 6.1, 6.1, respectively; P &lt; 0.0001), but there were no differences among treatments at any sampling date (P &gt; 0.05). Conception rates were not different among treatments (P &gt; 0.10) but averaged 75, 67, 42, and 50% for the continuous-cool season, limit graze, supplemental feed, and tall fescue treatments, respectively. Crude protein (CP) concentrations for the control and limit grazing fescue treatments were greater than the limit grazing cool-season annual treatment, continuous grazing cool-season annual treatment, and the supplemental feed treatment (13.5, 10.7, 10.4, and 8.9%, respectively, (P &lt; 0.012). Neutral detergent fiber (NDF) and acid detergent fiber (ADF) were different among the supplemental treatment when compared with the limit grazing fescue, limit grazing cool-season annual, control, and continuous cool-season annual (48.2 vs 64.7% NDF and 25.8 vs. 37.0% ADF; P &lt; 0.0361). At this time, the results indicate that limit grazing cool-season annual forages may be an advantageous option to mitigate fescue toxicosis in replacement heifers grazing tall fescue pastures in the spring.
23 Comparison of Whole Cottonseed to a Traditional Supplement (20% Breeder Cubes) in Commercial Beef Cows: Impacts on Animal Performance, Metabolites, and Methane Emissions
Authors: Liuzzo Avianna A , Reuter Ryan R , Wilson Blake K 
Published: May 2023

Abstract
The objective was to compare whole cottonseed (WCS) with a more traditional supplement (20% breeder cube; BC) to determine the impacts on animal performance, metabolites, and methane emissions in beef cows. Cows (n = 24) were assigned to 1 of 2 experimental treatments (BC vs. WCS) based on age and body weight (BW). Supplements were fed individually at 0.9, 1.8, or 2.7 kg per day, resulting in 12 animals per supplement treatment and 4 animals per supplementation level within treatment. Two additional cows served as negative controls. Cows were fed 4 days per week, with supplementation levels being prorated at 1.6, 3.2, and 4.8 kg per feeding. Data collection occurred in 28-day intervals through d 84, with a final collection on d 99 after all cows finished calving. An amount fed per d × d interaction for BW change (P = 0.001) was detected. Cattle that were not supplemented (control) or received 0.9 kg per day lost more BW than cows that received 1.8 or 2.7 kg of supplement per day. There was a body condition score (BCS) change interaction for amount fed per d × d (P = 0.009). There was an amount fed per d × d interaction for back fat thickness (BFT; P = 0.02), and a tendency for an effect of amount fed per day on BFT (P = 0.07). There was a tendency for an amount fed per d × d interaction for fecal score (FS; P = 0.09) indicating that cattle receiving different amounts of supplement had varying trends in FS over time. A day effect was also observed for fecal score (P = 0.00003). There were no interactions (P ≥ 0.55), effect of treatment (P = 0.85), or effect of amount fed per d (P = 0.45) for fecal pH. A treatment × amount fed per d × d interaction for plasma glucose concentrations (P = 0.04) was detected. An amount fed per d × d interaction was detected for plasma lactate concentrations (P = 0.01) indicating that cattle receiving different amounts of supplement had different trends in lactate concentrations over time. An effect of amount fed per d on plasma lactate concentrations (P = 0.05) was also observed. A tendency for an amount fed per d × d interaction for plasma urea nitrogen (PUN; P = 0.06) was observed indicating that cattle receiving different amounts of supplement had varying trends in PUN over time. No treatment effect on methane emissions was observed between cows consuming BC and WCS (P = 0.68). This experiment suggests that the supplementation of BC or WCS had minimal impacts on performance, metabolites, or methane emissions, but some interactions existed between supplementation source or level and day.
37 Supplemented with Yucca Schidigera Extract to Feedlot Cattle Consuming Diets with or Without Monensin
Authors: Mackey Shea , Cooke Reinaldo F , Pickett Autumn , Mendes Egleu , Batista Luis Fernando , Colombo Eduardo 
Published: May 2023

Abstract
This experiment compared performance and physiological responses of feedlot cattle receiving a saponin containing feed ingredient manufactured from purified extract of Yucca schidigera [Micro-Aid (MA); DPI Global, Porterville, CA] which replaced or was fed in conjunction with feed-grade antimicrobials. Yearling, Angus-influenced steers (n = 20) arrived at the experimental feedlot on d -19 and a shrunk body weight (BW; 309 ± 4 kg) was immediately recorded. Steers were ranked by BW and allocated to 4 groups of 30 steers each. Groups were housed in of 4 drylot pens equipped with GrowSafe automated feeding systems (4 bunks/pen) during the experiment (d -15 to 69). On d 0 groups were randomly assigned to receive a total mixed ration containing: monensin and tylosin (RT; 360 mg/steer daily from Rumensin and 90 mg/steer daily from Tylan; Elanco Animal Health, Greenfield, IN) and/or 4 g/steer daily of MA in a 2 × 2 factorial arrangement of treatments. During the experimental period non-supplemented (CON) steers received a total mixed ration containing no additives. Individual feed intake was recorded daily, and steer BW was recorded every 28 d and before slaughter. Steers were slaughtered according to BW and slaughter groups were balanced by treatments (36 steers on d 120, 36 steers on d 146, and 48 steers on d 174). Carcass traits were recorded upon slaughter. On d 55 eight rumen-cannulated heifers were housed with yearling steers (1 pair/pen). Pairs rotated among groups every 21 d, resulting in a 4 × 4 Latin Square design (n = 8 per treatment) with a 5-day washout between rotations. Rumen fluid was collected from pairs on d 55, 75, 90,110, 125, 145, 160, and 180 (beginning and end of each 21-day rotation) and pH was recorded immediately after collection. No RT × MA treatment interactions were detected (P &gt; 0.10). Feed intake was decreased (P &lt; 0.01) in steers receiving RT, whereas feed efficiency was greater (P = 0.02) in steers receiving RT. Carcass variables including hot carcass weight, backfat thickness, Longissimus muscle area, marbling, yield grade, and percent of carcasses grading choice or better did not differ among treatments (P ≥ 0.17). Rumen fluid pH was greater (P = 0.04) in steers receiving RT. Steers receiving MA had greater (P = 0.03) rumen fluid pH and decreased (P = 0.04) rumen fluid viscosity. Collectively, supplementing feedlot cattle with Yucca schidigera extract improved rumen pH and viscosity, but failed to impact performance or carcass measures in feedlot cattle.