bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study of Analytical and Finite Element Analysis Numerical Approaches of the Equivalent Thickness of Large 4H-SiC Taiko Wafers
Authors: Vinciguerra Vincenzo , Malgioglio Giuseppe Luigi , Landi Antonio , Rascunà Simone , Renna Marco 
Published: September 2023

Abstract
The successful handling of large semiconductor wafers is crucial for their production on a large scale. Recently, the development of pilot lines using 8" wide band gap substrates, such as silicon carbide, has brought about similar challenges. Early-stage warpage control is essential to prevent uncontrolled asymmetric warpage, known as wafer bifurcation or buckling, which can occur with 8" 4H-SiC substrates, too. Moreover, the manufacturing process for large 4H-SiC wafers can be challenging due to warping during finishing and processing. Even in a gravity-free environment, thinning an 8" or 12" wafer can result in warpage and bifurcation. To mitigate this issue, the taiko method, which involves creating a thicker ring region around the rim of the wafer, has been widely used. Previous research has focused on the theoretical factors affecting the warpage of a backside metalized taiko wafer. This study extends the case of a front-side metalized taiko wafer and introduces the concept of the equivalent thickness to a 4H-SiC large taiko wafer. The equivalent thickness lies between the thickness of the central region and the annular region due to the influence of the ring region. Modelling can be helpful due to the limited number of taiko wafers that can be produced in a production line. In the investigation we developed both an analytical approach and a finite element analysis (FEA) with ANSYSY® software to model the equivalent thickness of a 4H-SiC taiko wafer. We investigated the curvature as a function of the stress of the metal layer, considering key design factors such as the substrate region thickness, thin metal film thickness, step height, and width of the annular ring region. By systematically varying the thickness of the central region of the taiko wafer, we investigated the curvature as a function of stress induced by thermal loads in the linear regime. The aim of this study is to identify regularities and similarities with the Stoney equation and investigate the validity of the analytical approach for the case of a 4H-SiC substrate.
Self-reported competence among advanced practice nursing students in Denmark, Finland and Norway: A cross-sectional multicentre study
Authors: Martinsen Randi , Ahlin-Søvde Sigrid , Grov Ellen Karine , Andersson Ewa K , Gardulf Ann 
Published: September 2023

Abstract

Background: The healthcare systems in Nordic countries and worldwide are under press due to increase in the population of older people and shortage of nurses. Educating nurseswith a high level of competence, such as advanced practice nurses is of great importance to secure effective, safe and high-quality care.
Aim: The aim of this study was to investigate self-reported competence among master’s students of advanced practice nursing in Denmark, Finland and Norway.
Methods: A multicentre, cross-sectional study design was used and conducted at five universities in Denmark, Finland and Norway. The Nurse Professional Competence Scale Short-Form forming six competence areas was used with a maximum score 7 per item for analysis of single items and a transformed 1-100 scale for analysing the competence areas (higher score, higher self-reported competence). Descriptive and comparative statistics were used to analyse the data.
Results: The highest mean score was found for the competence area ‘Value-based nursing care’. Students living with home-dwelling children (≤18 years) reported a significantly higher competence regarding ‘Nursing care’, while students ³33 years reported significantly higher competence regarding ‘Nursing care’ and ‘Value-based Nursing care’. No significant differences were found between the students working or not working alongside their studies, between students with or without further nursing-related education or between students having long or short experiences as nurses.
Conclusion: The findings from this study might contribute to a further development of the curriculums in advanced practice nursing to ensure high-quality nursing and a sustainable health care in the future. Future high-quality master’s programmes might benefit from a systematically collaboration between Nordic higher education institutions. Higher age, having children at home and working while studying should not be considered factors of concern.
Confirmation of negative urine culture status after appropriate antibiotic treatment prior to endourological stone procedures: Is it really necessary?
Authors: Sahin Cahit , Sobay Resul , Asik Alper , Sahinler Emre Burak , Yildirim Salih , Kul Kamil , Sarica Kemal 
Published: September 2023

Abstract
To evaluate the necessity of confirmation for a negative urine culture test outcome after an appropriate antibiotic regimen for urinary tract infection (UTI) prior to endoscopic stone removal procedures. 170 cases with culture proven UTI and undergoing an appropriate antibiotic regimen based on test outcomes before endoscopic stone removal were evaluated in two groups: Group 1 (n = 85) Patients receiving culture based antibiotic therapy and had a second urine culture test for “sterile urine” status prior to the procedures and Group 2 (n = 85) Patients receiving the same antibiotic therapy and had no additional urine culture test further. Cases were comparatively evaluated with respect to the statistical significance of postoperative infective complications (fever, sepsis) and the duration of hospital stay and re-admission rates during early post-operative period. Our findings showed that no significant difference was present regarding the rate of infective complications (presence of fever, incidence of septic findings), hospitalization period and readmission rates between two groups. Although the presence of a sterile urine has been confirmed by urine culture test in group 1 cases, no additional urine culture was performed with this aim in group 2 cases ( sterile urine was confirmed with only urinalysis) and the outcomes regarding the infective problems were found to be similiar. Our current findings indicate that a second urine culture test may not be a “ must” if the patients receive an appropriate antibiotic regimen based on the sensitivity test outcomes for a reasonable time period.
Potential Antioxidative Effects of Folic Acid and Betaine Combination Against to Amyloid beta (1-42) and Homocysteine-induced Oxidative Stress in Synaptosomes
Authors: Özkoç Mete , Can Betül , İlhan Ayşegül Oğlakçı , Söğüt İbrahim , Ataizi Zeki Serdar , Kandemir Turan , Dönmez Dilek Burukoğlu , Kanbak Güngör 
Published: September 2023

Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease and common type of dementia. Increasing number of death due to the disease has made it an important public health problem to be solved. Extracellular accumulation of amyloid beta (Aβ) peptide and hyperphosphorylated tau proteins in intracellular matrix are two major signs of the AD. In many research high levels of homocysteine (Hcy) were noted in AD. Oxidative stress appears as one of the significant factors in AD pathogenesis. Synaptosomes are substantial physiological membranous structures and can be utilized one of the in vitro models of AD. In this study, synaptosomal fractions were obtain from forebrain of rats and study groups were separated into five: control, Aβ(1–42), Aβ(1–42) + Hcy, Aβ(1–42) + Hcy + Folic Acid + Betaine, Betaine + Folic Acid. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were evaluated. In Aβ(1–42) + Hcy group the high levels of TOS (0.2 ± 0.05 mol H2O2 eq/L), OSI (34.47 ± 4.41) and MDA (2,29 ± 0.42 nmol/g protein) were remarkable findings compared the control group. Administration of folic acid and betaine in combination recovered the harmful effect of Aβ(1 42) + Hcy by decreasing the TOS, OSI and MDA levels and increasing the TAS (0.41 ± 0.11mmol Trolox eq/L). In conclusion, Hcy and Aβ peptide together can lead to neurodegeneration by increasing the oxidative stress and this detrimental effect can be eliminated by administration of folic acid and betaine.
Online self-calibration and time synchronization of camera and IMU in substation scenarios
Authors: Zhang Chenwei , Zeng Pingliang , Jin Tao , Tu Mingyang 
Published: September 2023

Abstract
As smart grids continue to evolve, inspection robots based on vision and inertial measurement unit (IMU) fusion systems (VIO) have become increasingly critical for ensuring safe operation and maintenance within substations.The implementation of VIO requires precise alignment of internal and external parameters, initialization, and synchronization of the IMU and camera sensor clocks.In this paper, a joint camera-IMU initialization algorithm is proposed that enables online self-calibration and time synchronization of camera and IMU, it extends the open-source VINS-Mono system to utilize depth data in the VIO phase. The algorithm proposed in this paper is evaluated through experiments performed on the EuRoC dataset. The results are compared with vision-only systems, VINS-Mono, and VI-ORB systems, demonstrating the potential for improved system performance compared to other algorithms. Moreover, a mobile robot platform equipped with vision and IMU sensors is built to verify the utility and effectiveness of the algorithm in real-world scenarios.
Tackling social disconnection: An umbrella review of RCT-based interventions targeting social isolation and loneliness
Authors: Hansen Thomas , Nes Ragnhild Bang , Hynek Kamila , Nilsen Thomas S. , Reneflot Anne , Stene-Larsen Kim , Tornes Ragnhild , Bidonde Julia 
Published: September 2023

Abstract
Background
Social isolation and loneliness are urgent public health concerns associated with negative physical and mental health outcomes. Understanding effective remedies is crucial in addressing these problems.
Objectives
To synthesize and critically appraise scientific evidence on the effectiveness of social isolation and loneliness interventions overall and across subgroups. We focused on systematic reviews (SRs) of randomized controlled trials (RCTs).
Methods
We searched seven databases (June 2022 and updated June 2023) and supplemented the search with grey literature and reference screening to identify SRs published since 2017. Screening, data extraction, and quality assessment using the AMSTAR2 tool were conducted independently by author pairs, with disagreements resolved through discussion.
Findings:
We included 29 SRs, 16 with meta-analysis and 13 with narrative synthesis. All SRs focused on loneliness, with 12 additionally examining social isolation. Four SRs focused on young people, 11 on all ages, and 14 on older adults. The most frequently examined intervention types were social (social contact, social support), psychological (therapy, psychoeducation, social skills training), and digital (e.g., computer use and online support). Meta-analyses indicated small-to-moderate beneficial effects, while narrative synthesis demonstrated mixed or no effect. Social interventions for social isolation and psychological interventions for loneliness were the most promising. However, caution is warranted due to the effects’ small magnitude, significant heterogeneity, and the variable quality of SRs. Digital and other interventions showed mixed or no effect; however, caution is advised in interpreting these results due to the highly diverse nature of the interventions studied.
Conclusion
This overview of SRs shows small to moderate effectiveness of social interventions in reducing social isolation and psychological ones in tackling loneliness. Further rigorously conducted RCTs and SRs are needed to guide policy decisions regarding the implementation of efficacious and scalable interventions. Evaluation should focus on both preventive structural interventions and tailored mitigating strategies that address specific types and causes of loneliness.
Housing Quality Index Analysis at the Urban Axis Level in Eastern and Western Europe Using Ses Analysis Case Study: Bistrita-Cluj-Napoca -Debrecen-Békéscsaba- Bourges- Chateauroux -Pamplona -Zaragoza
Authors: Tătar Marius Alexandru 
Published: September 2023

Abstract
The size of the home is considered the most critical issue affecting the quality of life. This can be measured by the quality of the house and its environment. This paper highlights the housing quality index at the urban axis level the urban axes of Western and Eastern Europe and the impact of socioeconomic activities on the index. The Household Quality of Life Index (HQLI) was calculated using 11 variables. Household quality of life comprises two distinctive indices: the Housing Conditions Index (HCI) and the Asset Possession Index (API). The study found a variation in the housing condition variables across the urban focus areas. The impact of the socioeconomic environments is disproportionately dependent on the social-economic profile of the urban environments that make up the Urban Axis and the related economic activities that take place in the area of influence in the administrative-territorial units and the variability of the Housing Conditions Index This can be measured by the quality of the house and its environment. This paper highlights the housing quality index at the urban axis and the impact of socioeconomic activities on this index.
The study area comprises territories in the urban axis in Western Europe and the urban axis in Eastern Europe. The socio-economic context of the area has been the basis for understanding the patterns of evolution identified in the urban landscape and being a driver in ongoing urban transformations and processes. The impact of the socio-economic is disproportionate to the socioeconomic profile of the urban environments that make up the Urban Axis and the economic activities related to the economic activities taking place in the catchment area in the administrative-territorial units, hence the variability of the Housing Conditions Index which is a system Housing Quality Indicator (HQI) is a tool for measuring and evaluating housing systems based on quality and not just cost.
Vaccination prevents IL-1β-mediated cognitive deficits after COVID-19
Authors: Klein Robyn , Vanderheiden Abigail , Hill Jeremy , Jiang Xiaoping , Deppen Benjamin , Bamunuarachchi Gayan , Soudani Nadia , Joshi Astha , Cain Matthew , Boon Adrianus 
Published: September 2023

Abstract
Up to 25% of SARS-CoV-2 patients exhibit post-acute cognitive sequelae. Although millions of cases of COVID-19-mediated memory dysfunction are accumulating worldwide, the underlying mechanisms and how vaccination lowers risk are unknown. Interleukin-1, a key component of innate immune defense against SARS-CoV-2 infection, is elevated in the hippocampi of COVID-19 patients. Here we show that intranasal infection of C57BL/6J mice with SARS-CoV-2 beta variant, leads to CNS infiltration of Ly6Chi monocytes and microglial activation. Accordingly, SARS-CoV-2, but not H1N1 influenza virus, increases levels of brain IL-1β and induces persistent IL-1R1-mediated loss of hippocampal neurogenesis, which promotes post-acute cognitive deficits. Breakthrough infection after vaccination with a low dose of adenoviral vectored Spike protein prevents hippocampal production of IL-1β during breakthrough SARS-CoV-2 infection, loss of neurogenesis, and subsequent memory deficits. Our study identifies IL-1β as one potential mechanism driving SARS-CoV-2-induced cognitive impairment in a new murine model that is prevented by vaccination.
MODEL GAYA KEPEMIMPINAN TRANSFORMATIF DALAM MENINGKATKAN DAYA SAING PENDIDIKAN DI ERA INDUSTRI 4.0
Authors: Safi'i Asrop 
Published: September 2023

Organizational culture at the school level requires leaders who are creative, in mobilizing madrasah, so that the learning carried out becomes meaningful and produces quality education. Transformative leadership design model is needed as an effort to produce education that is competitive and produces students who have personality integrity, a disciplined attitude, are creative, innovative and competitive. This article seeks to elaborate on the transformative leadership model of madrasah headmaster in increasing the competitiveness of education in the industrial era 4.0 with the object of Madrasah Aliyah. Using library research, this article argues that transformative leaders have several indicators: first, the existence of team work that collaborates across the entire academic community. Second, there is an increase in teacher work ethic, thereby fostering teacher professionalism. Third, it enables the implementation of the supervisory leadership role. Fourth, creating madrasah organizational arrangements, a relationship climate that is loose coupling, and changing the structure and climate of the bureaucracy to a comfortable professional bureaucracy so as to enable the implementation of organizational leadership roles.
EDUCAÇÃO E ARQUIVOS
Authors: Sabino Fernanda de Matos Tostes , Gomes Priscila Ribeiro 
Published: September 2023

Este artigo é resultado do desenvolvimento de pesquisa relacionada ao Programa de Iniciação Científica da Universidade Federal do Estado do Rio de Janeiro, que culminou na escrita de trabalho de conclusão do curso de Arquivologia. O objetivo deste estudo voltou-se à realização de um levantamento acerca da produção bibliográfica em torno das interlocuções que envolvem os campos da Arquivologia e Educação, a partir de dois eventos: Congresso Nacional de Arquivologia (CNA) e a Reunião de Ensino e Pesquisa em Arquivologia (REPARQ), ambos eventos desde a data de criação. Além de apresentar um breve histórico sobre os eventos, a pesquisa também possibilitará aos interessados nos diálogos entre Arquivos e Educação identificar as possibilidades dos temas apresentadas nos eventos. Para atingir os objetivos propostos foram utilizados os métodos de pesquisa bibliográfico e documental acerca das produções do CNA e Reparq, que serviram como base para uma posterior análise comparativa.
Ethyl Acetate Fraction from Hedyotis Diffusa Plus Scutellaria Barbata
Inhibits the Progression of Breast Cancer via Targeting LMO1 and
AKT/Mtor Signaling Pathway
Authors: Li Zhiyuan , Li Jingwei , Liu Xiaofei , Sun Ziyuan , Sun Xiaohui 
Published: September 2023

Background:
Traditional Chinese medicines are widely used in cancer treatment. Scutellaria
barbata and Hedyotis diffusa herb pair (SH) has an anticancer effects in various tumors.
However, the specific mechanism of SH in breast cancer remains unclear.

Methods:
In the present research, we investigated the effect and regulatory network of SH in in
breast cancer. CCK8, colony formation, transwell, wound healing and flow cytometry analysis
were used for the detection of cell function.

Results:
Ethyl acetate fraction from SH at an equal weight ratio (EA11) could inhibit the proliferation,
migration and invasion of MCF7 and MDA-MB-231 cells. It also induced apoptosis in these
two cell lines by downregulating Bcl2 and upregulating Bax and Cleaved-Caspase3. SH reduced
the activation of the AKT/mTOR signaling pathway and the expression of p70S6K. Sequencing
results showed that LMO1 was significantly downregulated in SH-treated cells compared with control
cells. Importantly, overexpression of LMO1 attenuated the inhibitory effect of SH on cell proliferation
and invasion and induced inflammatory tumor microenvironment.

Conclusion:
In conclusion, the SH herb pair inhibited the proliferation and metastasis through
downregulating LMO1 expression and reducing the activation of the AKT/mTOR signaling pathway.
LMO1 has the potential as a new target in the treatment of breast cancer.
Role of Bioactive Compounds, Novel Drug Delivery Systems, and
Polyherbal Formulations in the Management of Rheumatoid Arthritis
Authors: Rana Neha , Gupta Piyush , Singh Hridayanand , Nagarajan Kandasamy 
Published: September 2023

Abstract:
Rheumatoid Arthritis (RA) is an autoimmune disorder that generally causes joint synovial
inflammation as well as gradual cartilage and degenerative changes, resulting in progressive
immobility. Cartilage destruction induces synovial inflammation, including synovial cell hyperplasia,
increased synovial fluid, and synovial pane development. This phenomenon causes articular
cartilage damage and joint alkalosis. Traditional medicinal system exerts their effect through several
cellular mechanisms, including inhibition of inflammatory mediators, oxidative stress suppression,
cartilage degradation inhibition, increasing antioxidants and decreasing rheumatic biomarkers.
The medicinal plants have yielded a variety of active constituents from various chemical
categories, including alkaloids, triterpenoids, steroids, glycosides, volatile oils, flavonoids, lignans,
coumarins, terpenes, sesquiterpene lactones, anthocyanins, and anthraquinones. This review sheds
light on the utilization of medicinal plants in the treatment of RA. It explains various phytoconstituents
present in medicinal plants and their mechanism of action against RA. It also briefs about the
uses of polyherbal formulations (PHF), which are currently in the market and the toxicity associated
with the use of medicinal plants and PHF, along with the limitations and research gaps in the
field of PHF. This review paper is an attempt to understand various mechanistic approaches employed
by several medicinal plants, their possible drug delivery systems and synergistic effects for
curing RA with minimum side effects.
Design and Simulation of a CdTe/C2N/SnO2 Trilayer Photovoltaic Cell viaSCAPS-1D
Authors: Meena Rupanjali , Lata Lalit kumar , Jain Praveen Kumar , Sethi Sarabjeet Singh 
Published: September 2023

Introduction:
Simulation of cadmium telluride (CdTe)-based solar cells (CdTe/C2N/SnO2) using Solar Cell Capacitance Simulator-1D (SCAPS-1D) has been presented in this article.

Method:
C2N was introduced as a buffer layer, SnO2 was introduced as a window layer, and CdTe was introduced as an absorber layer.

Result:
The impact of the thickness of the CdTe, SnO2, and C2N layers, the defect density and carrier concentration of the CdTe layer, and the impact of ambient temperature were analyzed.

Conclusion:
The optimized solar cell demonstrated a maximum power conversion efficiency (PCE) of 22.41% with an open circuit voltage (VOC) of 1.07 V, a short circuit current density (JSC) of 23.59 mA/cm2, and an FF of 88.51%, indicating huge promise in low-cost solar energy harvesting.