bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ising Cosmology
Authors: Irges Nikos , Kalogirou Antonis , Koutroulis Fotis 
Published: May 2023

AbstractUsing arguments from holography we propose that the deviation of the cosmological spectral index $$n_S$$

n
S

of scalar fluctuations from unity may be controlled almost entirely by the critical exponent $$\eta $$
η
of the $$d=3$$

d
=
3

Ising model.
Increasing the Robustness of TERO-TRNGs Against Process Variation
Authors: Skubich Christian , Reichel Peter , Reichenbach Marc 
Published: May 2023

The transition effect ring oscillator is a popular design for building entropy sources because it is compact, built from digital elements only, and is very well suited for FPGAs. However, it is known to be quite sensitive to process variation. Although the latter is useful for building physical unclonable functions, it is interfering with the application as an entropy source.
In this article, we investigate an approach to increase reliability. We show that adding a third stage eliminates much of the susceptibility to process variation and how a resulting gigahertz oscillation can be evaluated on an FPGA. The design is supported by physical and stochastic modeling. The physical model is validated using an experiment with dynamically reconfigurable look-up tables.
Fréchet Distance for Uncertain Curves
Authors: Buchin Kevin , Fan Chenglin , Löffler Maarten , Popov Aleksandr , Raichel Benjamin , Roeloffzen Marcel 
Published: May 2023

In this article, we study a wide range of variants for computing the (discrete and continuous) Fréchet distance between uncertain curves. An uncertain curve is a sequence of
uncertainty regions,
where each region is a disk, a line segment, or a set of points. A
realisation
of a curve is a polyline connecting one point from each region. Given an uncertain curve and a second (certain or uncertain) curve, we seek to compute the lower and upper bound Fréchet distance, which are the minimum and maximum Fréchet distance for any realisations of the curves.

We prove that both problems are NP-hard for the Fréchet distance in several uncertainty models, and that the upper bound problem remains hard for the discrete Fréchet distance. In contrast, the lower bound (discrete [
5
] and continuous) Fréchet distance can be computed in polynomial time in some models. Furthermore, we show that computing the expected (discrete and continuous) Fréchet distance is #P-hard in some models.

On the positive side, we present an FPTAS in constant dimension for the lower bound problem when Δ/δ is polynomially bounded, where δ is the Fréchet distance and Δ bounds the diameter of the regions. We also show a near-linear-time 3-approximation for the decision problem on roughly δ-separated convex regions. Finally, we study the setting with Sakoe–Chiba time bands, where we restrict the alignment between the curves, and give polynomial-time algorithms for the upper bound and expected discrete and continuous Fréchet distance for uncertainty modelled as point sets.
Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium
Authors: Gersekowski Kate , Ibiebele Torukiri I ,   for the Australian Ovarian Cancer Study Group, Doherty Jennifer A. , Harris Holly R. , Goodman Marc T. , Terry Kathryn L. , Wu Anna H. , Bandera Elisa V. , Qin Bo , Ong Jue-Sheng , Tyrer Jonathan P. , Dixon-Suen Suzanne C. , Modugno Francesmary , Risch Harvey A , Webb Penelope M. 
Published: May 2023

Abstract

Background:
Although folate intake has not been associated with an increased risk of ovarian cancer overall, studies of other cancer types have suggested that high folate intake may promote carcinogenesis in precancerous lesions. Women with endometriosis (a potential precancerous lesion) have an increased risk of developing ovarian cancer; however, whether high folate intake increases risk in this group is unknown.

Methods:
We conducted a pooled analysis of six case–control studies from the Ovarian Cancer Association Consortium to investigate the association between folate intake and risk of ovarian cancer among women with and without self-reported endometriosis. We included 570 cases/558 controls with and 5,171/7,559 without endometriosis. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals for the association between folate intake (dietary, supplemental, and total) and ovarian cancer risk. Finally, we used Mendelian randomization (MR) to evaluate our results using genetic markers as a proxy for folate status.

Results:
Higher dietary folate intake was associated with an increased risk of ovarian cancer for women with endometriosis [OR, 1.37 (1.01–1.86)] but not for women without endometriosis. There was no association between supplemental folate intake and ovarian cancer risk for women with or without endometriosis. A similar pattern was seen using MR.

Conclusions:
High dietary folate intake may be associated with an increased risk of ovarian cancer among women with endometriosis.

Impact:
Women with endometriosis with high folate diets may be at increased risk of ovarian cancer. Further research is needed on the potential cancer-promoting effects of folate in this group.
FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors
Authors: Duke Elizabeth S. , Bradford Diana , Marcovitz Michelle , Amatya Anup K. , Mishra-Kalyani Pallavi S. , Nguyen Emily , Price Lauren S.L. , Fourie Zirkelbach Jeanne , Li Yangbing , Bi Youwei , Kraft Jeffrey , Dorff Sarah E. , Scepura Barbara , Stephenson Maritsa , Ojofeitimi Idara , Nair Abhilasha , Han Yu , Tezak Zivana , Lemery Steven J. , Pazdur Richard , Larkins Erin , Singh Harpreet 
Published: May 2023

Abstract
On September 21, 2022, the FDA granted accelerated approval to selpercatinib (Retevmo, Eli Lilly and Company) for the treatment of adult patients with locally advanced or metastatic solid tumors with a rearranged during transfection (RET) gene fusion that have progressed on or following prior systemic treatment or who have no satisfactory alternative treatment options. The approval was based on data from Study LOXO-RET-17001 (LIBRETTO-001; NCT03157128), an international, non-randomized, multi-cohort clinical trial that included patients with advanced solid tumors harboring RET alterations. The overall response rate in 41 patients with locally advanced or metastatic RET fusion-positive solid tumors other than non–small cell lung cancer (NSCLC) or thyroid cancer was 44% [95% confidence interval (CI), 28%–60%], with median duration of response 24.5 months (95% CI, 9.2–not evaluable). Patients with 10 of 14 tumor types with a variety of fusion partners had objective responses, including patients with the following tumors: pancreatic adenocarcinoma, colorectal, salivary, unknown primary, breast, soft-tissue sarcoma, bronchial carcinoid, ovarian, small intestine, and cholangiocarcinoma. The recommendation for approval was supported by results from LIBRETTO-001 in patients with RET fusion-positive NSCLC and thyroid cancer, which formed the basis of prior approvals in these tumor types. The most common adverse reactions (&gt;25%) were edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, and headache. This is the first tissue-agnostic approval of a RET-directed targeted therapy.
Fibronectin Contributes to a BRAF Inhibitor–driven Invasive Phenotype in Thyroid Cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2
Authors: Hicks Hannah M. , Pozdeyev Nikita , Sams Sharon B. , Pugazhenthi Umarani , Bales Elise S. , Hofmann Marie-Claude , McKenna Logan R. , Schweppe Rebecca E. 
Published: May 2023

Abstract

Mutations in BRAF are common in advanced papillary and anaplastic thyroid cancer (PTC and ATC). However, patients with BRAF-mutant PTC currently lack therapies targeting this pathway. Despite the approved combination of BRAF and MEK1/2 inhibition for patients with BRAF-mutant ATC, these patients often progress. Thus, we screened a panel of BRAF-mutant thyroid cancer cell lines to identify new therapeutic strategies. We showed that thyroid cancer cells resistant to BRAF inhibition (BRAFi) exhibit an increase in invasion and a proinvasive secretome in response to BRAFi. Using reverse-phase protein array (RPPA), we identified a nearly 2-fold increase in expression of the extracellular matrix protein, fibronectin, in response to BRAFi treatment, and a corresponding 1.8- to 3.0-fold increase in fibronectin secretion. Accordingly, the addition of exogenous fibronectin phenocopied the BRAFi-induced increase in invasion while depletion of fibronectin in resistant cells resulted in loss of increased invasion. We further showed that BRAFi-induced invasion can be blocked by inhibition of ERK1/2. In a BRAFi-resistant patient-derived xenograft model, we found that dual inhibition of BRAF and ERK1/2 slowed tumor growth and decreased circulating fibronectin. Using RNA sequencing, we identified EGR1 as a top downregulated gene in response to combined BRAF/ERK1/2 inhibition, and we further showed that EGR1 is necessary for a BRAFi-induced increase in invasion and for induction of fibronectin in response to BRAFi.

Implications:
Together, these data show that increased invasion represents a new mechanism of resistance to BRAF inhibition in thyroid cancer that can be targeted with an ERK1/2 inhibitor.
Duty and Love: Flora Lee's Resistance to Slavery in Revolutionary Marblehead
Authors: O'brien G. Patrick 
Published: May 2023

Abstract
This study explores the life of Flora Lee, an enslaved Massachusetts woman, who had her daughter spirited away from her during the Revolution. Lee's efforts to be reunited with her daughter in Nova Scotia, and to protect other vulnerable Black children, highlight enslaved women's resistance to their family's enslavement during the Revolutionary Era.
The LOSC Renvois as a Source of Untapped Jurisdiction
Authors: Georgoula Danae F. 
Published: May 2023

Abstract
This article aims to contribute to the discussion around the jurisdictional effects of the express renvois in the substantive rules of the United Nations Convention on the Law of the Sea (LOSC). Through the lens of pre-existing scholarship on the function of the renvois, it examines the function of this type of provision in the Convention and attempts to delineate the scope of jurisdiction granted through them. It is posited that this jurisdiction can be both broad and dynamic, but it has remained largely untapped by States and the judiciary. Prompted by this observation, the possible reasons behind this underutilisation are examined and finally, possible ways to use this mechanism to judicially address some of the contemporary challenges that the ocean is facing are outlined.
Comparative Analysis of NSQIP National Outcomes and Projected Outcomes versus Our Institutional Outcomes for Robotic Gastrectomy: The Future of Gastric Resection
Authors: Ross Sharona B. , Slavin Moran , Sucandy Iswanto , Crespo Kaitlyn L. , Syblis Cameron C. , Saravanan Sneha , Rosemurgy Alexander S. 
Published: May 2023

Background The robotic approach has vast applications in surgery; however, the utility of robotic gastrectomy has yet to be clearly defined. This study aimed to compare outcomes following robotic gastrectomy at our institution to the national patient-specific predicted outcomes data provided by the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP). Methods We prospectively studied 73 patients who underwent robotic gastrectomy under our care. ACS NSQIP outcomes after gastrectomy and predicted outcomes for our patients were compared with our actual outcomes utilizing students t test and chi-square analysis, where applicable. Data are presented as median (mean ± SD). Results Patients were 65 (66 ± 10.7) years old with a BMI of 26 (28 ± 6.5) kg/m2. 35 patients had gastric adenocarcinomas and 22 had gastrointestinal stromal tumors Operative duration was 245 (250 ± 114.7) minutes, estimated blood loss was 50 (83 ± 91.6) mL, and there were no conversions to ‘open’. 1% of patients experienced superficial surgical site infections compared to the NSQIP predicted rate of 10% ( P < .05). Length of stay (LOS) was 5 (6 ± 4.2) days vs NSQIP’s predicted LOS of 8 (8 ± 3.2) days ( P < .05). Three patients died during their postoperative hospital course (4%), due to multi-system organ failure and cardiac arrest. 1-year, 3-year, and 5-year estimated survival for patients with gastric adenocarcinoma was 76%, 63%, and 63%, respectively. Discussion Robotic gastrectomy yields salutary patient outcomes and optimal survival for varying gastric diseases, particularly gastric adenocarcinoma. Our patients experienced shorter hospital stays and reduced complications relative to patients in NSQIP and predicted outcome for our patients. Gastrectomy undertaken robotically is the future of gastric resection.
National recommendations to standardise acute kidney injury detection and alerting
Authors: Marrington Rachel , Barton Anna L , Yates Alexandra , McKane William , Selby Nicholas M , Murray Jonathan S , Medcalf James F , MacKenzie Finlay , Myers Martin 
Published: May 2023

Background National Health Service England issued a Patient Safety Alert in 2014 mandating all acute Trusts in England to implement Acute Kidney Injury (AKI) warning stage results and to do so using a standardised algorithm. In 2021, the Renal and Pathology Getting It Right First Time (GIRFT) teams found significant variation in AKI reporting across the UK. A survey was designed to capture information on the entire AKI detection and alerting process to investigate the potential sources of this unwarranted variation. Methods In August 2021, an online survey consisting of 54 questions was made available to all UK laboratories. The questions covered creatinine assays, laboratory information management systems (LIMS), the AKI algorithm and AKI reporting. Results We received 101 responses from laboratories. Data were reviewed for England only – 91 laboratories. Findings included that 72% used enzymatic creatinine. In addition, 7 manufacturer-analytical platforms, 15 different LIMS and a wide range of creatinine reference ranges were in use. In 68% of laboratories, the AKI algorithm was installed by the LIMS provider. Marked variation was found in the minimum age of AKI reporting with only 18% starting at the recommended 1 month/28-days. Some 89% phoned all new AKI2s and AKI3s, as per AKI guidance while 76% provided comments/hyperlinks in reports. Conclusions The national survey has identified laboratory practices that potentially contribute to unwarranted variation in the reporting of AKI in the England. This has formed the basis for improvement work to remedy the situation, including national recommendations, included within this article.
Empathy and psychological concerns among medical students in Brazil during the COVID-19 pandemic
Authors: Wercelens Victor Oliveira , Bueno Mariana Leles , Bueno Julia Leles , Abrahim Roberta Perfeito , Ydy Julia Guimarães Mauad , Zanetti Hugo Ribeiro , Montayre Jed , Maximiano-Barreto Madson Alan 
Published: May 2023

Objective Being in direct contact with COVID-19 patients for long periods increases the risk of infection among frontline workers. The purpose of this study was to identify levels of empathy and psychological concern among medical students during the COVID-19 pandemic. Methods An online cross-sectional study was conducted among medical interns divided into two groups: those who worked on the frontline (n = 87) and those who did not (n = 63) during the COVID pandemic. The students completed the Interpersonal Reactivity Index, Maslach Burnout Inventory, Perceived Stress Scale, and Patient Health Questionnaire. Results The majority of respondents were women (70.7%), and the mean age was 25.45 ± 3.93 years. In unadjusted analyses, those who worked with COVID-19 patients had a higher level of empathy, stress, burnout symptoms, and depressive symptoms. In the logistic regression analyses, students who worked on the frontline during the COVID-19 pandemic had a higher level of empathy (OR: 1.27; 95% CI: 1.16-1.14), higher perceived stress levels (OR: 1.21; 95% CI: 1.05-1.39), and greater burnout symptoms (OR: 1.19; 95% CI: 1.10-1.30). Conclusion Medical students in the internship period who worked on the frontline during the COVID-19 pandemic had more psychological concerns and higher levels of empathy compared to those who did not work on the frontline.
Optic neuropathy diagnosis in the emergency room - retrospective observational study of the last 18 years
Authors: Cardoso Daniel , Bezerra Sofia , Soares-dos-Reis Ricardo , Sá Maria José , Guimarães Joana 
Published: May 2023

Introduction Optic neuropathies (ON), a broad spectrum of disorders of the optic nerve, are a frequent cause of visual loss, presenting either in isolation or associated to neurological or systemic disorders. They are often first evaluated in the Emergency Room (ER) and a rapid determination of the etiology is imperative for implementing timely and appropriate treatment. We aim to describe ER demographic data and clinical characteristics, as well as the performed imaging exams, of patients subsequently hospitalized and diagnosed with ON. Furthermore, we seek to explore the accuracy of ER discharge diagnosis and evaluate possible predictive factors that may influence it. Methods We retrospectively reviewed the medical records of 192 patients admitted to the ward of the Neurology Department of Centro Hospitalar Universitário São João (CHUSJ), with a discharge diagnosis of ON. Subsequently, we selected those admitted from the ER, with clinical, laboratory and imaging data, between January 2004 and December 2021. Results We included 171 patients. All participants were discharged from the ER and admitted in the ward with a main diagnostic suspicion of ON. Patients were stratified according to suspected etiology at the time of discharge: 99 inflammatory (57.9%), 38 ischemic (22.2%), 27 unspecified (15.8%) and 7 other (4.1%). By comparing with current follow-up diagnosis, 125 patients had an accurate ER diagnosis category (73.1%), 27 had an ON diagnosis of unspecified etiology that was defined only during follow-up (15.8%) and 19 had an inaccurate diagnosis category (11.1%). Diagnostic change was more common with ER ischemic diagnosis (21.1%) compared to inflammatory diagnosis (8.1%) (p = 0.034). Conclusions Our study reveals that most patients with ON can be accurately diagnosed in the ER through clinical history neurological and ophthalmological evaluation.
The effects of traditional Muslim prayer positions on intraocular pressure in subjects with and without glaucoma
Authors: Dar Nimrod , Zhalka Fidaa , Atta Dalila Abu , Burgansky-Eliash Zvia , Belkin Avner 
Published: May 2023

Purpose To compare the magnitude and duration of intraocular pressure (IOP) increase during the two principal Islamic prayer positions, Rukū (standing while bowing forward at a 90-degree angle), and Sujud (kneeling with the forehead touching the ground) in healthy subjects and patients with primary open-angle glaucoma (POAG). Methods Prospective, observational case series. Ninety-five eyes of 47 patients (27 with POAG and 68 without POAG) were included. Eligible candidates underwent IOP measurements in the sitting position and in two prayer positions using the Goldmann applanation tonometer and the Icare-Pro tonometer. IOP was measured at set intervals until it returned to baseline. Results Mean IOP increased from a sitting baseline value of 16.1  ±  2.9 mmHg (8.6-26) to 19.3  ±  4.2 mmHg (10.2-32.3) following 30 s of Rukū (p ≤ 0.0001) and from 16.1  ±  0.4 mmHg to 22.2  ±  3.1 mmHg (14.9-37) following Sujud (p ≤ 0.0001). IOP increased similarly in the POAG and non-POAG groups in both positions. Twenty-six eyes (27%) failed to normalize within 2mmHg of baseline, but all returned to baseline after another five minutes. Conclusions Performing traditional Muslim prayer positions increases IOP significantly. The increase did not resolve immediately in approximately a quarter of individuals. These findings may have a considerable impact on Muslim patients with glaucoma.
Identity and parent-child relationship representations of Nezha: From cultural narrative to case conceptualization
Authors: Guo Ruitong , Li Xianghui 
Published: May 2023

ObjectiveBased on the assumption that the cultural image at the level of experience is the collective and individual psychological reality expressed by cultural narrative and individual narrative, to study the timeless Tales of Nezha (“Natch”) in China as an experiential cultural image of child development and parent-child relationship.MethodWe adopted the narrative analysis method which focused on qualitative content analysis, covering religion, folklore, literature, entertainment, education and other fields.ResultOur exposition articulates a cultural narrative framework of diachronic and contemporary cultural image of “Nezha”, the iconic child deity. This framework refers to our academic research discipline of describing the image characteristics, plots and interpersonal relationship, and conceptualizing the theme as psychological meaning units of personal identity and parent-child relationship. By analogizing and comparing this framework with the “Nezha” of personal narratives in consultation, we found the interactive clues of the case’s identity and parent-child relationship. We then combined these with specific elements unique and particular to each individual case in order to achieve a meaningful case conceptualization. This process enabled us to apply psychotherapeutic intervention at opportune moments during a counselling session.ConclusionsThe cultural image emerging from the counseling is not only a personal narrative of resource and a tool for the client to externalize the problem and identity representation, but also a cultural narrative reference point for the counselor to understand the case and to engage in further in-depth work. The personal narrative qualitative data can be obtained by referring to four dimensions: external—internal, event—image, narrative—interpretation, and experience—reflection. With the narrative identity of client, the “Nezha” of personal narrative led to the theme that parent-child relationship impedes the development of personal identity. The counselor was thereby enabled to construct a new meaning and new identity with the client by providing appropriate information and knowledge of the cultural narrative.
How Much Technically Efficient Is The South Asian Region? An Intra-Regional Comparison Among Its Affiliates
Authors: Arora Nitin , Ganaie Ishfaq Ali 
Published: May 2023

This study presents an analysis of the intra-regional performance of South Asian economies in terms of their productive efficiency during the period 1985–2019. A window data envelopment analysis (dea) based technique with bootstrapping is used to model the production frontier for seven South Asian economies to estimate their efficiency levels. The results show substantial differences in technical efficiency levels across South Asian economies and thus, the existence of vast potential to catch up with the best practices is revealed among these economies. On an average, the extent of technical inefficiency in south asia is about 46.92% per annum after adjusting for statistical bias. This is indicative of a huge gap in laggard and best practices within region. Both managerial and scale components of efficiency performance are equally responsible for observed production inefficiency in south asia. The existence of managerial inefficiency reflects failure of policy planners among affiliate countries to catch-up the best practices within South Asian region. However, the observed scale inefficiency (SIE) is because of the dominance of scale economies over diseconomies that urges need of enlarging cooperation among member nations. JEL Codes: F02, D240, C610