bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inconsistent radiographic diagnostic criteria for Lisfranc injuries: a systematic review
Authors: Seow Dexter , Yasui Youichi , Yi Tammy Chan Li , Kubo Maya , Nei Masashi , Matsui Kentaro , Kawano Hirotaka , Miyamoto Wataru 
Published: June 2023

Abstract
Purpose
To evaluate the radiographic diagnostic criteria and propose standardised radiographic criteria for Lisfranc injuries.
Methods
A systematic review of the PubMed and Embase databases was performed according to the PRISMA guidelines. The various radiographic criteria for the diagnosis of Lisfranc injuries were extracted. Descriptive statistics were presented for all continuous (as mean ± standard deviation) and categorical variables (as frequencies by percentages).
Results
The literature search included 29 studies that totalled 1115 Lisfranc injuries. The risk of bias ranged from “Low” to “Moderate” risk according to the ROBINS-I tool. The overall recommendations according to the GRADE assessment ranged from “Very Low” to “High”. 1st metatarsal to 2nd metatarsal diastasis was the most common of the 12 various radiographic diagnostic criteria observed, as was employed in 18 studies. This was followed by 2nd cuneiform to 2nd metatarsal subluxation, as was employed in 11 studies.
Conclusion
The radiographic diagnostic criteria of Lisfranc injuries were heterogeneous. The proposition for homogenous radiographic diagnostic criteria is that the following features must be observed for the diagnosis of Lisfranc injuries: 1st metatarsal to 2nd metatarsal diastasis on anteroposterior view or 2nd cuneiform to 2nd metatarsal subluxation on anteroposterior or oblique views. Further advanced imaging by CT or MRI may be required in patients with normal radiographs but with continued suspicion for Lisfranc injuries.
Level of Evidence:
4, systematic review
Improving groundwater quality through managed aquifer recharge
Authors: Day Andrew , Senevirathna Lalantha 
Published: June 2023

Abstract
The treatment of raw groundwater sources with high levels of problematic constituents, such as hardness and salinity, presents a significant challenge to water network operators and local councils and is a costly process to undertake on a continued basis. With the growing emergence of managed aquifer recharge (MAR) as a mainstream and accepted practice, some significant benefits and efficiencies can be achieved from recharging groundwater with higher quality water, including recycled water sources that have already been treated for problematic constituents in the initial abstraction process. The benefit of conducting aquifer recharge and effectively diluting the source water is that continued dilution improves groundwater quality. While this concept has been proven and is in practice in numerous contexts worldwide, it has yet to be explored within the regional Australian context. As such, it was identified that a gap exists within this body of knowledge and that it was justified to ascertain the viability of this practice on a real water supply network. To this end, an investigation of managed aquifer recharge for Bungendore, NSW was undertaken. This was done through an in-depth analysis of the town’s groundwater usage and existing water quality parameters, along with the determination of available water budgets and feasible locations for implementation. The research results were then further validated using computational fluid dynamics modelling, resulting in potential positive outcomes for the Bungendore context, which, if implemented, could result in significant water quality improvement and a reduction of treatment requirements for problematic constituents in groundwater supplies.
Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial
Authors: Esaki Mitsuru , Ihara Eikichi , Manabe Noriaki , Kawami Noriyuki , Iwakiri Katsuhiko , Akiyama Junichi , Kuribayashi Shiko , Uraoka Toshio , Ogino Haruei , Chinen Takatoshi , Misumi Akiko , Watanabe Hiroko , Suzuki Maya , Kishimoto Junji , Ogawa Yoshihiro 
Published: June 2023

Abstract
Background
We have determined that the impaired accommodation of the lower esophageal sphincter (LES) underlies the pathogenesis of esophagogastric junction outflow obstruction (EGJOO). We have also found that acotiamide may treat EGJOO by improving impaired LES accommodation. The effects of acotiamide in patients with EGJOO need to be further confirmed in a prospective study.
Methods
This trial is a multicenter, randomized, double-blind, placebo-controlled study to compare the efficacy and safety of acotiamide (300 mg/day or 600 mg/day) with those of a placebo in the treatment of patients with EGJOO. The primary endpoint will be the proportion of patients who report an improvement in symptom of food sticking in the chest after 4 weeks of treatment period 1. The secondary endpoints will be the proportion of patients with normalized integrated relaxation pressure (IRP), the value of change from baseline in the distal contractile integral, basal LES pressure, EGJOO–quality of life score, Gastrointestinal Symptom Rating Scale, and the correlation between IRP and each symptom score. During the 2-year trial period, 42 patients from five institutions will be enrolled.
Discussion
This trial will provide evidence to clarify the efficacy and safety of acotiamide as a treatment for patients with EGJOO. Acotiamide might help improve the quality of life of patients with EGJOO and is expected to prevent the progression of EGJOO to achalasia.
Trial registration
This study was approved by the Institutional Review Board (IRB) of Kyushu University Hospital as well as the local IRBs of the participating sites for clinical trials and registered in the Japan Registry of Clinical Trials (jRCT: 2071210072)
Lemon Peel Essential oil and its Nano-Formulation as green alternatives Bioinsecticides to control Agrotis ipsilon (Lepidoptera: Noctuidae)
Authors: Ahmed Habiba A. , Nassrallah Amr A. , Abdel-Raheem Mohamed A. , Elbehery Huda H. 
Published: June 2023

Abstract
Due to excessive use of synthetic pesticides the pest resistance developed along with pesticide residues accumulation in crops. Therefore, in order to control pests, many nations are switching from chemical-based agriculture to "green" agriculture, which makes extensive use of biopesticides. The destructive pest black cutworm, Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae), is a polyphagous species that economically lead to loss to a broad range of crops including corn, cotton, wheat and many vegetables through the damage of foliar and roots. In this study we tested the lethal activity of Lemon Peel Essential Oil (LPEO) and its nano-form (LPEO-NPs) against the biological parameters of the black cutworm, Agrotis ipsilon(Hufnagel). Lemon Peel Essential Oil (LPEO) has insecticidal activity against the black cutworm and causes different levels of effects on biological parameters of A. ipsilon according to its concentration and formulation. The overall data points to possible uses of nanoformulated essential oils in pest control. The overall data points to possible uses of nanoformulated essential oils in pest control.
Tandem Stenosis of the Cervical and Thoracic Spine ： A Systematic Review
Authors: Lin Yanze , Jinlei Zhou , Wang Xun , Yao Wenchao , Wu Ruiji , Feng Fabo 
Published: June 2023

Abstract

Background
Tandem spinal stenosis (TSS) is a condition where the spinal canal is narrowed in two or more regions of the spine. The most common locations of TSS are in the cervical and lumbar spine, but it can also occur in the cervical and thoracic spine. The simultaneous occurrence of cervical and thoracic spinal stenosis can result in complicated symptoms, which may cause missed and delayed diagnosis. Additionally, tandem cervical and thoracic stenosis (TCTS) may affect the decision-making process of surgeons when contemplating either one-staged or two-staged surgery. Currently, there is no agreed-upon strategy for surgical intervention of TCTS in the literature.
Methods
Medical databases in English (Pubmed, Web of Science, Embase, the Cochrane Database of Systematic Reviews) and Chinese (CNKI, Wanfang Data, CMJD) were searched using Medical Subject Heading queries for the terms “tandem cervical and thoracic stenosis”,“cervical stenosis AND thoracic stenosis”, “tandem spinal stenosis” and “concomitant spinal stenosis” from January 1980 to March 2023. We included studies involving adult individuals with TCTS. Articles only focused on disorders in the single spine area or didn't mention spinal disorders were excluded.
Results
A total of 1625 literatures were initially considered for inclusion. After removing duplicates using EndNote, and screening literatures abstract and the full-texts, 23 clinical studies met the inclusion criteria. Of these, 2 studies solely focused on missed diagnosis, 19 studies exclusively discussed surgical strategy for TCTS, and 2 articles evaluated both surgical strategy and missed diagnosis.
Conclusion
Our study revealed a missed diagnosis rate of 7.2% in TCTS, with the thoracic stenosis being the most commonly overlooked area. Therefore, precise identification of TCTS is of utmost importance as the initial step in its management. Although both one-staged and two-staged surgeries have demonstrated effectiveness, the optimal surgical plan should be selected based on the patients' unique circumstances.
Elastic fiber alterations and calcifications in calcific uremic arteriolopathy Running head: Elastin alteration and calcifications in CUA
Authors: Colboc Hester , Moguelet Philippe , Bazin Dominique , Letavernier Emmanuel , Sun Chenyu , Chessel Anatole , Carvalho Priscille , Lok Catherine , Dillies Anne-Sophie , Chaby Guillaume , Maillard Hervé , Kottler Diane , Goujon Elisa , Jurus Christine , Panaye Marine , Tang Ellie , Courville Philippe , Boury Antoine , Monfort Jean-Benoit , Chasset François , Senet Patricia , Schanne-Klein Marie-Claire 
Published: June 2023

Abstract
Calcific uremic arteriolopathy (CUA) is a severely morbid disease, affecting mostly dialyzed end-stage renal disease (ESRD) patients, associated with calcium deposits in the skin. Calcifications have been identified in ESRD patients without CUA, indicating that their presence is not specific to the disease. The objective of this retrospective multicenter study was to compare elastic fiber structure and skin calcifications in ESRD patients with CUA to those without CUA using innovative structural techniques. Fourteen ESRD patients with CUA were compared to 12 ESRD patients without CUA. Analyses of elastic fiber structure and skin calcifications using multiphoton microscopy followed by machine-learning analysis and field-emission scanning electron microscopy coupled with coupled with energy dispersive X-ray were performed. Elastic fibers specifically appeared fragmented in CUA. Quantitative analyses of multiphoton images showed that they were significantly straighter in ESRD patients with CUA than without CUA. Interstitial and vascular calcifications were observed in both groups of ESRD patients, but vascular calcifications specifically appeared massive and circumferential in CUA. Unlike interstitial calcifications, massive circumferential vascular calcifications and elastic fibers straightening appeared specific to CUA. The origins of such specific elastic fiber’s alteration are still to be explored and may involve relationships with ischemic vascular or inflammatory processes.
Potential of Fucoidan From Myriogloea Major Asensi as Antiviral Against Herpes Simplex Type 1 and 2 and Bovine Coronavirus
Authors: Conesa Ana Lucía , Dellatorre Fernando Gaspar , Latour Ezequiel , Ponce Nora Marta Andrea , Stortz Carlos A. , Scolaro Luis Alberto , Álvarez Vera Alejandra , Lassalle Verónica Leticia , Ayala-Peña victoria Belen 
Published: June 2023

Abstract
Fucoidans are fucose-rich sulfated polysaccharides that display a wide array of biological properties and are found mainly in brown seaweeds. These compounds possess interesting pharmacological perspectives for antiviral and antioxidant drug development. Myriogloea major Asensi (Chordariaceae; Ectocarpales) is an endemic brown seaweed from Argentine Patagonia similar to other members of the Chordariaceae family used as a commercial fucoidan source. This alga is a potential resource and the fucoidans obtained from it have not been studied until now. In this work, we studied the chemical composition and the anti- HSV-1, HSV-2 and Bovine Coronavirus, and antioxidant activity of fucoidan extracts from M. major thalli. The dry weights from two pooled extracts represented 42% of the extracted dried biomass. Chemical analysis showed that the extracts contained between 15 and 20% of sulfates and approximately 80% of fucose constituents on their polysaccharides. The total phenolic content was lower than 1% (Gallic acid equivalents) and antioxidant activity was lower than 50% at a concentration of 1 mg/ml in both extracts. We demonstrated that in the presence of fucoidan extracts the viral attachment to the cell was reduced by up to 75%; applying its antiviral action to block the viral infection, this way the progeny virus released from host cells was significantly restricted, without affecting cell-to-cell spread or virus viability.
A Modal Conditional Mean Spectrum for Nonlinear Structural Response Time-History Analysis of Tall Buildings to Consider Higher Mode Effects
Authors: Du Ke , Gao Jiawei , Ji Kun , Bai Jiulin 
Published: June 2023

Abstract
Selection and scaling of an appropriate suite of earthquake ground motion records for consistency with a target spectrum are associated with nonlinear structural response time-history analysis. The commonly used target spectrum could be a uniform hazard spectrum (UHS), conditional (mean) spectrum (CMS or CS). The CMS (CS) overcomes the limitations of the “overly conservative” and “unrealistic spectral shape” of UHS and has been accepted as a more reasonable target spectrum recently. However, the CMS only selects a single conditional period (usually the first period T1 of the structure) ignoring the influence of the high-order vibration mode (other periods) on the structure. To address this, this paper proposes a modal conditional mean spectrum (MCMS) considering the influence of higher-order modes by weighted (measured using the modal participation mass ratio) averaging the CMS under each period of the structure. The MCMS matches CMS(T1) at a period T" (T"< T1). The spectrum values of MCMS are significantly higher than those of CMS(T1) for periods shorter than T" and slightly lower than those of CMS(T1) for periods longer than T". Then, two typical high-rise case structures (symmetric and asymmetric structures) with different elevations are designed, and the MCMS, CMS(T1) and UHS are used as target spectra for nonlinear structural response time-history analysis for comparison. Based on the analysis of four engineering demand parameters, namely peak floor acceleration (PFA), peak floor velocity (PFV), peak floor displacement (PFD), and maximum interstory drift ratio (IDR), it was found that the results of the UHS were consistently higher than those of the CMS(T1) and the MCMS. However, it was also observed that the PFA results of MCMS were higher than those of CMS(T1), whereas the PFD, PFV, and IDR results of MCMS were lower than those of CMS(T1). It should be noted that MCMS is a target spectrum that takes into account the influence of higher-order mode effects in CMS.
Existential distress and associated factors in advanced cancer patients: a cross-sectional study
Authors: Xu Guiru Xu , Lin Xiaodan , Xiao Huimin , wu Hong , Yang Shangwang , Lin Xiaoyan , Zheng Jianwei 
Published: June 2023

Abstract
Objective: This study aimed to investigate the current state of existential distress and identify its associated factors in advanced cancer patients.
Methods: A cross-sectional study was conducted among 352 advanced cancer patients from three tertiary hospitals in Fujian, China. Participants were invited to finish Existential Distress Scale, Number Rating Scale, Self-perceived Burden Scale, Quality of Life Concerns in the End of Life Questionnaire, and Hospital Anxiety and Depression Scale.
Result: A total of 352 advanced cancer patients were recruited in this study. The average score of existential distress was 8.48±7.12 among advanced cancer patients. Multiple regression showed that its associated factors were depression (β= 0.32, P=0.000), self-perceived burden (β= 0.18, P=0.001), spouse (β= -0.10, P=0.050), and government subsidies (β= 0.17, P=0.001). The factors accounted for 30.1% of the total variance in existential distress (F=8.472, P＜0.001).
Conclusion: Existential distress is positively influenced by depression, self-perceived burden, and government subsidies, but negatively influenced by a spouse among advanced cancer patients. Depression is its most important risk factor, and future existential distress interventions could target at depression.
The expression and clinical significance of MATK in chronic hypoperfusion patients with white matter hyperintensity
Authors: Zhao Ming , Zhang Jiayue , Yang Qianqian , Shi Zhang , Shen Hongjian , Pu Yingyan , Han Yi 
Published: June 2023

Abstract

Background
Chronic cerebral hypoperfusion (CCH) is one of the important causes of vascular cognitive impairment, and such people can often be found with white matter hyperintensity (WMH) under magnetic resonance imaging (MRI). This study aimed to investigate the expression and clinical significance of MATK in CCH patients with WMH.
Methods
A total of 42 patients with CCH complicated with WMH were defined as the WMH group and 45 healthy volunteers as the control group. The peripheral blood mononuclear cell (PBMC) levels of MATK were separated and detected by quantitative real-time polymerase chain (qPCR). A correlation analysis of MATK level and Fazekas scales in patients with WMH was also conducted.
Results
The qPCR results showed that the relative MATK expression was downregulated in the WMH group compared to the control group; the expression of MATK in the control group was 1.84 ± 0.87, while the expression of MATK in the WMH group was 1.20 ± 0.99, which was a statistically significant difference (t = 3.24, P < 0.01). Correlation analysis showed that the MATK level in the WMH group was negatively correlated with the Fazekas scale of WMH (R2 = 0.3405, P < 0.001). MOCA (OR, 0.766; 95% CI 0.594–0.986; P < 0.05) and MATK (OR, 0.498; 95% CI 0.268–0.927; P < 0.05) were independent high-risk factors to predict the clinical outcomes of WMH in patients with CCH.
Conclusions
The expression of MATK in the peripheral blood of CCH patients was negatively correlated with the severity of WMH, and it may help CCH patients identify the progression of WMH as early as possible.
High Fidelity Synthetic Face Generation for Rosacea Skin Condition from Limited Data
Authors: Mohanty Anwesha , Sutherland Alistair , Bezbradica Marija , Javidnia Hossein 
Published: June 2023

Abstract
Similar to the majority of deep learning applications, diagnosing skin diseases using computer vision and deep learning often requires a large volume of data. However, obtaining sufficient data for particular types of facial skin conditions can be difficult due to privacy concerns. As a result, conditions like Rosacea are often understudied in computer-aided diagnosis. The limited availability of data for facial skin conditions has led to the investigation of alternative methods for computer-aided
diagnosis. In recent years, Generative Adversarial Networks (GANs), mainly variants of StyleGANs, have demonstrated promising results in generating synthetic facial images. In this study, for the first time, a small dataset of Rosacea with 300 full-face images is utilized to further investigate the possibility of generating synthetic data. The preliminary experiments show how fine-tuning the model and varying experimental settings significantly affect the fidelity of the Rosacea features. It
is demonstrated that R1 Regularization strength helps achieve high-fidelity details. Additionally, this study presents qualitative evaluations of synthetic/generated faces by expert dermatologists and non-specialist participants. The quantitative evaluation is presented using a few validation metric(s). Furthermore a number of limitations and future directions are discussed.
The role of mesenchymal estrogen receptor 1 in mouse uterus in response to estrogen
Authors: Furuminato Keita , Minatoya Saki , Seno Eriko , Goto Tatsuki , Yamazaki Sho , Sakaguchi Moeka , Toyota Kenji , Iguchi Taisen , Miyagawa Shinichi 
Published: June 2023

Abstract
Estrogens play important roles in uterine growth and homeostasis through estrogen receptors (ESR1 and ESR2). To address the role of ESR1-mediated tissue events in the murine uterus, we analyzed mice with a mesenchymal tissue-specific knockout of Esr1. Isl1-driven Cre expression generated Esr1 deletion in the uterine stroma and endometrium (Isl-Esr1KO). We showed that overall structure of the Isl1-Esr1KO mouse uterus developed normally, but estrogen responsiveness and subsequent growth were defective, suggesting that mesenchymal ESR1 is necessary for both epithelial and mesenchymal cell proliferation. Furthermore, RNA-seq analysis revealed that the majority of estrogen-induced genes were regulated by stromal ESR1. In control mice, E2 administration induced 9476 up-regulated differentially expressed genes (DEGs), whereas only 1801 up-regulated DEGs were induced by E2 in Isl1-Esr1KO mice. We further showed that stromal ESR1-regulated genes in the mouse uterus included several growth factors and cytokines, which are potential factors that regulate epithelial and stromal tissue interaction, and also genes involved in lipid homeostasis. Therefore, we infer that stromal ESR1 expression is indispensable for most estrogen actions in the mouse uterus and the current results provide new insights into estrogen-mediated homeostasis in female reproductive organs.
An Efficient and Eco-Friendly Tandem Approach for Spirooxindoles Synthesis
Authors: Verma Asha , Arya Dinesh Kumar , Kumar Sandeep , Pathak Gargi , Khatri Vineeta 
Published: June 2023

Abstract
The synthetic procedure of substantially diverse spiro[benzothiazolo[3,2-a]pyrimidine-4,3'-indolines] was created via a highly potent and ecologically friendly tandem technique. The synthesis methodology uses L-proline to serve as a recoverable and recyclable catalyst for the reaction of isatin, and malononitrile, with 2-amino benzothiazole using an aqueous environment.
Comparing of EPDM/SIR insulation performance and mechanism analysis of the distribution cable accessories under moisture condition
Authors: Sun Weixin , Guo Kongying , Luo Wen , Li Guochang , Wei Yanhui , Liang Xiaojian , Nie Yongjie 
Published: June 2023

Abstract
Moisture in the insulation of distribution cable accessories is one of the important causes of insulation degradation and discharge failure of the accessories. The changes in the insulation properties of EPDM (Ethylene-Propylene-Diene Monomer) and SIR (Silicone Rubber) with the time of dampness are studied, and the mechanism of dampness is revealed by combining the surface water absorption characteristics and functional group analysis. The results show that the hydrophobicity of EPDM specimens is lower than that of SIR, resulting in the electrical properties of EPDM being significantly lower than those of SIR after water immersion. The resistivity and the flashover voltage of both specimens decrease significantly with the increase of moisture exposure time, and the decrease of EPDM is more obvious than that of SIR. The breakdown voltage of EPDM decreases by 26.6% and that of SIR decreased by 13.06%. Besides, the flashover voltage along the surface of both EPDM and SIR decreases with the increase of water immersion time, and the decreasing trend of both of them is basically the same. This work has guiding significance for the material selection of the cable accessories and the analysis of damp failure.