bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an integrated multi-objective approach to formulate optimal harvesting policies with the aim of sustainable management of groundwater resources: study area: Varamin Plain
Authors: Azizi Hamid reza , Azizi Hamed 
Published: March 2023

Abstract
In the present study, an integrated multi-objective simulation -optimization model was developed using a NSGA-II optimization algorithm and GMS simulation software with the aim of sustainable harvesting from the Varamin aquifer. For this purpose, the quantitative model of the aquifer was simulated. Based on the calibrated model and integrated with the optimization algorithm, a two-objective management model was developed to control the exponential drop in the groundwater level and ensure sustainable harvesting from the wells. Then, according to multi-criteria decision-making methods and the Borda aggregation method, the optimal harvesting scenario of wells in operation was analyzed. The results show that more than 69% of the wells in the study area have experienced a rise of up to 30 m in the groundwater level during a 1-year period. It indicates the relative improvement of the aquifer in the direction of restoring its saturated thickness. Also, the comparison of the results obtained from the optimal and existing conditions showed that by applying the proposed model, an average of 46.9% can be saved in the harvesting of groundwater resources. For this purpose, it is necessary to reduce the allowed amount of harvesting from wells in this area from 21 to 11 L/s.
TempNet – temporal super-resolution of radar rainfall products with residual CNNs
Authors: Sit Muhammed Ali , Seo Bongchul , Demir Ibrahim 
Published: March 2023

AbstractThe temporal and spatial resolution of rainfall data is crucial for environmental modeling studies in which its variability in space and time is considered as a primary factor. Rainfall products from different remote sensing instruments (e.g., radar, satellite) have different space-time resolutions because of the differences in their sensing capabilities and post-processing methods. In this study, we developed a deep-learning approach that augments rainfall data with increased time resolutions to complement relatively lower-resolution products. We propose a neural network architecture based on Convolutional Neural Networks (CNNs), namely TempNet, to improve the temporal resolution of radar-based rainfall products and compare the proposed model with an optical flow-based interpolation method and CNN-baseline model. While TempNet achieves a mean absolute error of 0.332 mm/h, comparison methods achieve 0.35 and 0.341, respectively. The methodology presented in this study could be used for enhancing rainfall maps with better temporal resolution and imputation of missing frames in sequences of 2D rainfall maps to support hydrological and flood forecasting studies.
Long-term spatiotemporal variability of precipitation and its linkages with atmospheric teleconnections in the Yellow River Basin, China
Authors: Wang Junjie , Chi Yuning , Shi Bing , Yuan Qingyun , Wang Xia , Shen Lijun 
Published: March 2023

AbstractPrecipitation is widely considered as a crucial index toward the apprehension of global climate change. Hence, it becomes imperative to explore spatiotemporal patterns and the interlinked factors of precipitation in the basin. In the study, the spatial and temporal variability of precipitation and the individual or integrated effects of various atmospheric teleconnections on precipitation variations are explored in the Yellow River Basin. The total precipitation showed a slightly declining tendency during 1950–2019 and the dependence relationship of precipitation gradient on latitude and longitude is different in various seasons and elevations. The spatiotemporal variability of precipitation is more sensitive to the latitude gradient. For each 1-degree increase in longitude and latitude, the average annual precipitation increases/decreases by 10.73 and 57.24 mm, respectively. Moreover, the precipitation spatiotemporal patterns could be interpreted by four empirical orthogonal functions (EOFs) modes about 71.9% of precipitation variations. The strength of the linkages between various circulation factors and precipitation varied at different time scales. The integrated effects of multiple factors should be taken into consideration in explaining precipitation variability at all time scales. It is expected that the study can be helpful for understanding the internal mechanism of the hydrological cycle in the YRB.
Spatial analysis of historical extreme rainfall characteristics using regionalization in the Lake Biwa and Yodo River Basin, Japan
Authors: Yazawa Taishi , Shoji Ayane 
Published: March 2023

AbstractThis research investigated the historical changes in basin-scale rainfall characteristics and their spatial distributions in the Lake Biwa and Yodo River Basin. Nine rainfall indices including two general and seven extreme rainfall indices and the probable rainfall according to 50- and 100-year return periods were evaluated based on the data gathered from 61 rain gauge stations. The regionalization of the rainfall indices and probable rainfall was then examined using spatial interpolation via the Kriging method. The results of the spatial analysis for the rainfall indices showed that there is a potentially high risk of extreme rainfall events and pluvial floods, particularly in the northern, western, and southern areas. The 50- and 100-year probable rainfall has historically increased in the north through to the western area of the basin. The return periods of the 50- and 100-year rainfall events decreased in the northern area of Lake Biwa and the western area of the basin. The findings of this research suggest that the local flood management plan needs to be updated depending on the regional differences in extreme rainfall characteristics. In basins/areas with sparsely distributed rain gauge stations, regionalization can provide useful information as part of local flood management planning.
Naegleria australiensis isolated from a wastewater treatment station in Santiago Island, Cape Verde
Authors: Sousa-Ramos Djeniffer , Reyes-Batlle María , Bellini Natalia Karla , Rodríguez-Expósito Rubén Leocadio , Piñero José Enrique , Lorenzo-Morales Jacob 
Published: March 2023

Abstract
Despite the Naegleria genus being isolated from different natural environments such as water, soil, and air, not all Naegleria species are capable of causing infections in humans, and they are capable of completing their life cycle in environmental niches. However, the presence of this genus may suggest the existence of one of the highly pathogenic free-living amoeba (FLA) species: Naegleria fowleri or the brain-eating amoeba. This facultative parasitic protozoon represents a risk to public health, mainly related to domestic and agricultural waters. In this research, our main objective was to determine the existence of pathogenic protozoa in the Santa Cruz wastewater treatment plant, Santiago Island. Using 5 L of water we confirmed the presence of potentially pathogenic Naegleria australiensis, being the first report on Naegleria species in Cape Verde. This fact demonstrates the low efficiency in the treatment of wastewater and, consequently, a potential threat to public health. Nevertheless, more studies will be needed for the prevention and control of possible infections in this Macaronesian country.
Effective removal of microcystin by a hybrid process combining PAC-submerged hollow fiber membrane from raw water
Authors: Sengul Ayse , Ersan Gamze , Yalçın Albayrak Eda , Rajab Mafaz Ali , Tüfekci Neşe 
Published: March 2023

Abstract
Microcystis aeruginosa is one of the most commonly detected cyanobacteria in aquatic systems. Therefore, this study evaluated the removal efficiency of total (cell-bound and dissolved) microcystin (MC) by a hybrid process combining powdered activated carbon (PAC)-submerged hollow fiber membrane and compared the hybrid process performance with that of PAC adsorption and submerged hollow fiber membrane processes separately. The results indicated that up to 84% of the total MC was removed using the PAC adsorption stand-alone process, while 90% of it was removed by submerged hollow fiber membrane stand-alone process (with a 10 μg/L feed concentration). When the PAC dose of 20 mg/L and equilibrium time of 480 min were applied with a 51.9 μg/L feed concentration to the hybrid process, the removal efficiency of total MC increased to 99%. Moreover, the cell-bound and dissolved MC concentrations in the permeate were 0.34 and 0.65 mg/L, respectively. This permeate concentration level was ensured by the World Health Organization (WHO) as the guideline value for MC (1 mg/L). Overall, the hybrid process combining PAC-submerged hollow fiber membranes can be successfully used as an alternative advanced treatment technology to mitigate total (cell-bound and dissolved) MC.
Network Pharmacology Study to Reveal the Mechanism of Zuogui Pill for
Treating Osteoporosis
Authors: Wang Gaoxiang , Li Huilin , Zhao Hengxia , Liu Deliang , Chu Shufang , Lee Maosheng , Fang Zebin 
Published: March 2023

Background:
To our knowledge, there is still a lack of scientific reports on the pharmacological
mechanism of the Zuogui Pill (ZGP) for treating osteoporosis (OP).

Aims:
This study aimed to explore it via network pharmacology and molecular docking.

Methods:
We identified active compounds and associated targets in ZGP via two drug databases.
Disease targets of OP were obtained utilizing five disease databases. Networks were established
and analyzed through the Cytoscape software and STRING databases. Enrichment analyses were
performed using the DAVID online tools. Molecular docking was performed using Maestro,
PyMOL, and Discovery Studio software.

Results:
89 drug active compounds, 365 drug targets, 2514 disease targets, and 163 drug-disease
common targets were obtained. Quercetin, kaempferol, phenylalanine, isorhamnetin, betavulgarin,
and glycitein may be the crucial compounds of ZGP in treating OP. AKT1, MAPK14, RELA,
TNF, and JUN may be the most important therapeutic targets. Osteoclast differentiation, TNF,
MAPK, and thyroid hormone signaling pathways may be the critical therapeutic signaling pathways.
The potential therapeutic mechanism mainly relates to osteoblastic or osteoclastic differentiation,
oxidative stress, and osteoclastic apoptosis.

Conclusion:
This study has revealed the anti-OP mechanism of ZGP, which offers objective evidence
for relevant clinical application and further basic research.
A Pay-It-Forward Approach to Improve Chlamydia and Gonorrhea Testing Uptake Among Female Sex Workers in China: Venue-Based Superiority Cluster Randomized Controlled Trial
Authors: Tang Weiming , Xie Yewei , Xiong Mingzhou , Wu Dan , Ong Jason J , Wi Teodora Elvira , Yang Bin , Tucker Joseph D , Wang Cheng 
Published: March 2023

Background
Regular chlamydia and gonorrhea testing are essential for key populations, such as female sex workers (FSWs). However, testing cost, stigma, and lack of access prevent FSWs in low- and middle-income countries from receiving chlamydia and gonorrhea testing. A social innovation to address these problems is “pay it forward,” where an individual receives a gift (free testing) and then asks whether they would like to give a gift to another person in the community.

Objective
This cluster randomized controlled trial examined the effectiveness and cost of the pay-it-forward strategy in increasing access to chlamydia and gonorrhea testing among FSWs in China.

Methods
This trial integrated a pay-it-forward approach into a community-based HIV outreach service. FSWs (aged 18 years or older) were invited by an outreach team from 4 Chinese cities (clusters) to receive free HIV testing. The 4 clusters were randomized into 2 study arms in a 1:1 ratio: a pay-it-forward arm (offered chlamydia and gonorrhea testing as a gift) and a standard-of-care arm (out-of-pocket cost for testing: US $11). The primary outcome was chlamydia and gonorrhea test uptake, as ascertained by administrative records. We conducted an economic evaluation using a microcosting approach from a health provider perspective, reporting our results in US dollars (at 2021 exchange rates).

Results
Overall, 480 FSWs were recruited from 4 cities (120 per city). Most FSWs were aged ≥30 years (313/480, 65.2%), were married (283/480, 59%), had an annual income <US $9000 (301/480, 62.7%), and had never been tested for chlamydia (401/480, 83.5%) or gonorrhea (397/480, 82.7%). Chlamydia and gonorrhea test uptake in the pay-it-forward and standard-of-care arms were 82% (197/240) and 4% (10/240), respectively, with an adjusted proportion difference of 76.7% (lower bound 95% CI 70.8%). All those who tested positive were referred to and received treatment at local sexually transmitted infection clinics. This finding was consistent when adjusting for marital status, income, inconsistent condom use during commercial sex in the last 3 months, and HIV testing history. Among 197 women who received tests in the pay-it-forward arm, 99 (50.3%) donated money, with a median donation of US $1.54 (IQR 0.77-1.54). The economic cost per person tested was US $568.71 for standard of care and US $43.20 for pay it forward.

Conclusions
The pay-it-forward strategy has the potential to enhance chlamydia and gonorrhea testing for Chinese FSWs and may be useful for scaling up preventive services. Further implementation research is needed to inform the transition of pay-it-forward research into practice.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2000037653; https://www.chictr.org.cn/showprojen.aspx?proj=57233
Development of Digital Booklet for Class X Biodiversity Materials
Authors: Prameswati Kencana Hastin , Saifuddin Much. Fuad 
Published: March 2023

Background: Distance learning requires learning media to help students understand the material. Digital booklets are an alternative to teaching biodiversity through visualization. This study aimed to determine the feasibility of digital booklets for class X biodiversity materials. Methods: This Research and Development use the ADDIE model. The product is validated by expert validators, material experts, and teachers. Product trials on students were divided into two groups, namely small groups (10 students) and large groups (30 students). Results: The results of the product assessment meet the very feasible category with scores of 91.67% (media experts), 61.25% (material experts), and 81.25% (teachers). The small group test on students obtained a percentage of 96%, and the big group test with a percentage of 95.33%. Conclusions: The digital booklet learning media product is suitable for class X biodiversity learning.
Bioecological Aspects of Snakeskin Gourami (Trichopodus pectoralis) in the Flooded Swamp Waters of Bilah River, Labuhanbatu Regency
Authors: Sinaga Fitriyani , Dimenta Rivo Hasper 
Published: March 2023

Background: The potential fish resources of snakeskin gourami (Trichopodus pectoralis) in the flooded swamp waters of Bilah river, Labuhanbatu Regency, are pretty high. Thus, this is one of the essential resources and has economic value. This study aimed to inform the bioecological aspects of snakeskin gourami fish (T. pectoralis). Methods: The determination of 3 sampling points was done using the purposive random sampling method. The sampling of T. pectoralis was carried out using the trap. The data analysis presented information on the abundance of Gonad Maturity Level, growth pattern, the Fulton (K) factor condition, and the Pearson correlation among environment parameters to the T. pectoralis population, which was presented quantitatively. Results: The results showed the length-weight relationship of T. pectoralis in the allometric category. The average relative weight (Wr) for male T. pectoralis was 100.46 ± 8.37, and for females was 99.83 ± 2.30. The mean value of the Fulton’s (K) factor condition in male T. pectoralis (8.94 ± 0.54) and female T. pectoralis (9.27 ± 0.67). Conclusions: T. pectoralis showed an allometric category and domination of the first gonadal maturity level. It describes that the female is abundant in optimum condition and ensures for future generations, and Pearson’s correlation result informs that increasing the value of environmental parameters will affect the optimization of T. pectoralis life.
Program Pendampingan Guru Pada Rancangan Program Ekoliterasi di Sekolah Inklusi
Authors: Lestari Sri , Tryanasari Dewi , Rahmasari Alfina Fitria 
Published: March 2023

Background: Adanya kesulitan pengorganisasian pada implementasi program ekoliterasi sebagai salah satu program penguatan literasi di SD Sukowinangun. Kesulitan terbesar yang dirasakan adalah kurangnya kemampuan tim literasi sekolah untuk merencanakan dan mengembangkan program ekoliterasi dan implementasinya. Untuk meningkatkan keterampilan tim literasi di sekolah dalam merencanakan program ekoliterasi yang relevan dengan kebutuhan pengembangan diri siswa. Metode: Mitra program pendampingan ini adalah SDN 2 Sukowinangun Magetan, dengan jumlah guru yang didampingi adalah 7, dan metode yang dilaksanakan adalah dengan melakasankan analisisis masalah dan kebutuhan, perencanaan kegiatan, pelaksanaan program, dan evaluasi pendampingan. Hasil: Program workshop dengan materi Identifikasi Perencanaan Proyek Penguatan Profil Pelajar Pancasila (P5) di SD berbasis Ekoliterasi telah terlaksana dengan maksimal. Selanjutnya rancangan program dan pendampingan pembuatan Lembar Kerja Siswa pada program ekoliterasi telah diselesaikan. Target program tercapai di mana tim literasi sekolah membuat rancangan program ekoliterasi selama 1 semester serta menjabarkannya dalam bentuk kegiatan terperinci dilengkapi dengan instrument penguatan pemahaman ekoliterasi. Berdasarkan pendampingan, workshop dan evaluasi yang telah dilaksanakan, dapat diketahui bahwa materi telah tersampaikan dengan baik dan mitra memberikan respon positif atas pelaksanaan.
Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study
Authors: Edstorp Jessica , Ahlqvist Emma , Alfredsson Lars , Mansour Aly Dina , Grill Valdemar , Rasouli Bahareh , Sørgjerd Elin P. , Tuomi Tiinamaija , Åsvold Bjørn O. , Carlsson Sofia 
Published: March 2023

OBJECTIVE
Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) aggravate these associations.

RESEARCH DESIGN AND METHODS
We used data from two population-based Scandinavian studies with case subjects with LADA (n = 839) and T2D (n = 5,771), matched control subjects (n = 3,068), and 1,696,503 person-years at risk. Pooled, multivariate relative risks (RR) with 95% CI were estimated for smoking/genetic risk scores (T2D-GRS, IS-GRS, and IR-GRS), and ORs for snus or tobacco/GRS (case-control data). We estimated additive (proportion attributable to interaction [AP]) and multiplicative interaction between tobacco use and GRS.

RESULTS
The RR of LADA was elevated in high IR-GRS heavy smokers (≥15 pack-years; RR 2.01 [CI 1.30, 3.10]) and tobacco users (≥15 box/pack-years; RR 2.59 [CI 1.54, 4.35]) compared with low IR-GRS individuals without heavy use, with evidence of additive (AP 0.67 [CI 0.46, 0.89]; AP 0.52 [CI 0.21, 0.83]) and multiplicative (P = 0.003; P = 0.034) interaction. In heavy users, there was additive interaction between T2D-GRS and smoking, snus, and total tobacco use. The excess risk conferred by tobacco use did not differ across GRS categories in T2D.

CONCLUSIONS
Tobacco use may confer a higher risk of LADA in individuals with genetic susceptibility to T2D and insulin resistance, whereas genetic susceptibility does not seem to influence the increased T2D incidence associated with tobacco use.
Mapping of Limestone Potential Using Landsat 8 Satellite Imageryin Some Areasof Timpeh
Authors: Roselini Sabrina , Arif Dian Adhetya , Putri Sri Kandi 
Published: March 2023

Limestone potential is important information that can be obtained from remote sensing data which has advantages and speed in processing results. Remote sensing is a technology that can overcome the problemof measuring data for fast and accurate information. This research was carried out in some areas of the Timpeh sub-district,andDharmasraya districtusing Landsat 8-OLI imagery with the aimof1) identifying the potential of limestone using the Band Ratio method. 2) How to apply remote sensing in mapping the potential of limestoneusing Landsat 8 Oli imagery.
This research was carried out in several stages, namely Pre Processing which included radiometric correction and atmospheric correction, image cropping according to the research area, and processing whichincluded making geological maps, making landform maps, making maps of river flow patterns and vegetationindex maps and limestone identification using the RGB band ratio method (5/4;6/3;4/2).
The results of field identification in potential limestone areas, where the RGB (Red Green Blue)composite of the band ratio 5/4;6/3;4/2 shows that the presence of limestone is characterized by the appearanceof greenish-brown colored objects. The average pixel value for limestone with a band ratio of 5/4 is 2.475, for a6/3 ratio is 1.275 and for a 4/3 ratio is 0.788. In this study, the potential area of limestone in the research areawasfound,whichwas approximately 2352,14564 ha.
Современные технологии управления медицинскими организациями. Критерии экономической и социальной эффективности управления МО
Authors: Лебедев Александр 
Published: March 2023

Ставшие традиционными критерии экономической и социальной эффективности управления МО, сложившиеся в период перехода к рыночной экономике, ранее освещались в научной периодике. Как правило, руководители и персонал коммерческих МО воспринимают эти критерии изолированно, полагая, что их материальное благополучие всецело определяется их личностными и профессиональными характеристиками, и не зависит от состояния внешней среды в целом, и от пролеченных ими больных, в частности.
В этой связи более детальное рассмотрение ряда вопросов, касающихся технологий управления МО представляется своевременным и актуальным.