bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of outcome of chemotherapy for breast cancer patients older than 70 years: A SEER-based study
Authors: Pu Shengyu , Xie Peiling , Chen Heyan , Li Yijun , He Jianjun , Zhang Huimin 
Published: March 2023

BackgroundWith the aging of the population, the number of elderly breast cancer cases has increased. However, there is a lack of effective randomized clinical trial data to support whether elderly patients should receive chemotherapy. Our goal was to observe the relationship between chemotherapy and breast cancer-specific survival (BCSS) in elderly breast cancer patients and to identify those who could benefit from chemotherapy.MethodsWe collected the data of patients who were diagnosed with invasive ductal carcinoma and older than 70 years in the SEER database from 1995 to 2016. The independent predictors of BCSS were identified by Cox regression analysis. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were performed to eliminate confounding factors.ResultsA total of 142,537 patients were collected, including 21,782 patients in the chemotherapy group and 120,755 patients in the non-chemotherapy group. We identified the same potential predictors of BCSS after PSM and IPTW, such as age, race, grade, stage, therapy, subtype. A nomogram for predicting 3-year, 5-year and 10-year BCSS was constructed. The 3-year, 5-year and 10-year AUCs of the nomogram were 0.842, 0.819, and 0.788. According to the risk stratification of model predictive scores, patients in the high-risk group achieved the greatest improvement in BCSS after receiving chemotherapy.ConclusionsOur study suggests that women older than 70 years with larger tumors, higher grade, positive nodes, negative hormone receptor and inactive local therapy gain prognostic benefits from chemotherapy, but for those with low- and median-risk, conventional chemotherapy should be administered cautiously.
Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis
Authors: Wang Xin-Xin , Mao Guang-Hui , Li Qi-Qi , Tang Jie , Zhang Hua , Wang Kang-Lin , Wang Lei , Ni Hong , Sheng Rui , Qin Zheng-Hong 
Published: March 2023

Background: Ischemic stroke seriously threatens human health because of high rates of morbidity, mortality and disability. This study compared the effects of nicotinamide adenine dinucleotide (NAD+) and butylphthalide (NBP) on in vitro and in vivo ischemic stroke models.Methods: Transient middle cerebral artery occlusion/reperfusion (t-MCAO/R) model was established in mice, and the cultured primary cortical neurons were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R). Cerebral infarct volume, neurobehavioral indices, antioxidant activity, ATP level and lactic acid content were determined. The neuroprotective effects of NAD+ or NBP were compared using sirtuin inhibitor niacinamide (NAM).Results: Intraperitoneal injection of NBP within 4 h or intravenous injection of NAD+ within 1 h after t-MCAO/R significantly reduced the volume of infarcts, cerebral edema, and neurological deficits. Administration of NAD+ and NBP immediately after t-MCAO/R in mice showed similar neuroprotection against acute and long-term ischemic injury. Both NAD+ and NBP significantly inhibited the accumulation of MDA and H2O2 and reduced oxidative stress. NAD+ was superior to NBP in inhibiting lipid oxidation and DNA damage. Furthermore, although both NAD+ and NBP improved the morphology of mitochondrial damage induced by ischemia/reperfusion, NAD+ more effectively reversed the decrease of ATP and increase of lactic acid after ischemia/reperfusion compared with NBP. NAD+ but not NBP treatment significantly upregulated SIRT3 in the brain, but the sirtuin inhibitor NAM could abolish the protective effect of NAD+ and NBP by inhibiting SIRT1 or SIRT3.Conclusions: These results confirmed the protective effects of NAD+ and NBP on cerebral ischemic injury. NBP and NAD+ showed similar antioxidant effects, while NAD+ had better ability in restoring energy metabolism, possibly through upregulating the activity of SIRT1 and SIRT3. The protection provided by NBP against cerebral ischemia/reperfusion may be achieved through SIRT1.
Feeding broilers with wheat germ, hops and grape seed extract mixture improves growth performance
Authors: Zou Qiangqiang , Meng Weishuang , Li Chunxiao , Wang Tieliang , Li Desheng 
Published: March 2023

In the study, Wheat germ, Hops and Grape seed extracts were made into a mixture (BX). The BX was supplemented in AA + broilers diets to investigate the effects of BX on broiler growth performance, blood indicators, microbiota, and noxious gas emissions in faeces. Four hundred and eighty 1-day-old AA + male broilers with an average initial body weight (44.82 ± 0.26) were randomly divided into four dietary treatments of six replicates each, with 20 birds per replicate. The experimental groups consisted of a group fed a basal diet and groups fed basal diet supplemented with 0.05%, 0.1%, and 0.2% BX. The trail was 42 days. The results showed that supplementing the dietary with graded levels of BX linearly increased ADG and ADFI from days 22–42 and 1–42. When dietarys supplemented with 0.2% BX significantly increased ADG and ADFI on days 22–42 and 1–42 (p &lt; 0.05). The addition of BX reduced H2S and NH3 emissions in the faeces; the levels of E. coli and Salmonella in the faeces were significantly reduced and the levels of Lactobacillus were increased (p &lt; 0.05). In this trial, when the diet was supplemented with 0.2% BX, faecal levels of E. coli and Salmonella were consistently at their lowest levels and Lactobacillus were at their highest. At the same time, NH3 and H2S emissions from broiler faecal also had been at their lowest levels. Conclusion: Dietary supplementation with a 0.2% BX could improve the growth performance of broilers and also reduced faecal H2S and NH3 emissions, as well as faecal levels of E. coli and Salmonella, and increased levels of Lactobacillus. Thus, BX made by Wheat germ, Hops and Grape seed extract is expected to be an alternative to antibiotics. And based on the results of this trial, the recommended dose for use in on-farm production was 0.2%.
Online health community for change: Analysis of self-disclosure and social networks of users with depression
Authors: Shi Jiayi , Khoo Zhaowei 
Published: March 2023

BackgroundA key research question with theoretical and practical implications is to investigate the various conditions by which social network sites (SNS) may either enhance or interfere with mental well-being, given the omnipresence of SNS and their dual effects on well-being.Method/processWe study SNS’ effects on well-being by accounting for users’ personal (i.e., self-disclosure) and situational (i.e., social networks) attributes, using a mixed design of content analysis and social network analysis.Result/conclusionWe compare users’ within-person changes in self-disclosure and social networks in two phases (over half a year), drawing on Weibo Depression SuperTalk, an online community for depression, and find: ① Several network attributes strengthen social support, including network connectivity, global efficiency, degree centralization, hubs of communities, and reciprocal interactions. ② Users’ self-disclosure attributes reflect positive changes in mental well-being and increased attachment to the community. ③ Correlations exist between users’ topological and self-disclosure attributes. ④ A Poisson regression model extracts self-disclosure attributes that may affect users’ received social support, including the writing length, number of active days, informal words, adverbs, negative emotion words, biological process words, and first-person singular forms.InnovationWe combine social network analysis with content analysis, highlighting the need to understand SNS’ effects on well-being by accounting for users’ self-disclosure (content) and communication partners (social networks).Implication/contributionAuthentic user data helps to avoid recall bias commonly found in self-reported data. A longitudinal within-person analysis of SNS’ effects on well-being is helpful for policymakers in public health intervention, community managers for group organizations, and users in online community engagement.
The subjective career success of women: The role of personal resources
Authors: Koekemoer Eileen , Olckers Chantal , Schaap Pieter 
Published: March 2023

IntroductionResearch on women’s career success has been the subject of extensive investigations, emphasizing the barriers they encounter in their careers. However, far less attention has been given to the personal resources that promote women’s career success. The purpose of our study was to provide more conclusive evidence regarding the role that personal resources such as resilience and grit can play in the relationship between women’s person-environment fit and the perceptions of their career success. Underpinned by the Job Demands Resources and social cognitive theory, our study aims to investigate whether resilience and grit could either explain how person-environment fit translates into feelings of subjective career success or could strengthen this relationship.MethodA cross-sectional online survey research design was used, and a convenience sample of 408 female employees was obtained. Relationships were explored through structural equation modelling.ResultsWhen controlling for age, the findings of this study revealed significantly positive relationships between the constructs, with person-environment fit, resilience, and grit, explaining a large portion of the variance in subjective career success. Although our data supported the mediating role of grit and resilience in the person-environment fit and subjective career success relationship, the moderating effects of grit and resilience could not be established.DiscussionThese findings illustrate both grit and resilience as mechanisms that indirectly affect the person-environment fit and subjective career success relationship of women. However, our findings indicate that resilience and grit cannot be considered mechanisms that would buffer against poor person-environment fit’s effect on their career success perceptions. Firstly, our study advances our understanding of the roles personal resources such as resilience and grit play in women’s career success as ways to overcome obstacles and workplace barriers. Secondly, using the motivational process of the Job Demands Resources Framework as theoretical background, we contribute by shedding light on how personal resources (resilience and grit) can be considered underlying factors influencing the person-environment fit and career success relationship for women. If women experience good person-environment fit, there is a greater opportunity for developing resilience and grit and, consequently, subjective career success.
Deficits in odor discrimination versus odor identification in patients with schizophrenia and negative correlations with GABAergic and DNA methyltransferase mRNAs in lymphocytes
Authors: Smith Robert C. , Sershen Henry , Youssef Mary , Lajtha Abel , Jin Hua , Zhang Mumei , Chen Anmei , Guidotti Alessandro , Davis John M. 
Published: March 2023

IntroductionPeople with schizophrenia have been reported to show deficits in tests of olfactory function. DNA methylation and GABAergic input have been implicated in biochemical processes controlling odor in animal studies, but this has not been investigated in human studies.MethodsIn a study of measures of DNA methylation and GABAergic mRNAs in lymphocytes, we also measured odor identification and discrimination with the Sniffin’ Sticks battery in 58 patients with chronic schizophrenia (CSZ) and 48 controls. mRNAs in lymphocytes were assessed by qPCR using TaqManTM probes. Cognition was assessed by the MATRICS battery (Measurement and Treatment Research to Improve Cognition in Schizophrenia) in CSZ and controls, and symptoms in CSZ were assessed by PANSS scale (Positive and Negative Symptom Scale). The relationships of odor deficits with mRNA, cognition, and symptoms were explored by correlation analysis. Variables which significantly differentiated CSZ from controls were explored by logistic regression.ResultsOverall, CSZ showed significantly (P≤.001) lower scores on odor discrimination compared to controls, with a moderate effect size, but no difference in odor identification. Deficits in odor discrimination, which has not been standardly assessed in many prior studies, strongly differentiated CSZ from controls. In logistic regression analysis, odor discrimination, but not odor identification, was a significant variable predicting schizophrenia versus control class membership. This is the first study to report relationship between odor deficits and DNA methylation and GABAergic mRNAs in blood cells of human subjects. There were negative correlations of odor identification with DNA methylation enzymes mRNAs and significant negative correlations with odor discrimination and GABAergic mRNAs. Lower odor scores were significantly associated with lower cognitive scores on the MATRICS battery in CSZ but not control subjects. In CSZ, lower odor scores were significantly associated with negative symptom scores, while higher odor identification scores were associated with PANNS Excitement factor.DiscussionOdor discrimination was a more powerful variable than odor identification in discriminating CSZ from controls and should be used more regularly as an odor measure in studies of schizophrenia. The substantive meaning of the negative correlations of odor discrimination and GABAergic mRNA variables in peripheral lymphocytes of CSZ needs more investigation and comparison with results in neural tissue.
How do local government information sources affect the purchase willingness of low-carbon agricultural products? The example of regional brand agricultural products
Authors: Xu Pu , Wang Linlin , Li Yufeng , Liu Min 
Published: March 2023

IntroductionIn order to achieve the carbon peaking and carbon neutrality goals, the agricultural sector has been given high priority to reduce carbon emissions. Since consumption is the ultimate goal of production, the consumption of low-carbon agricultural products is of great significance to promote the reduction of agricultural carbon emissions. Regional brand agricultural product is an important tool to promote the development of regional economy to “green, low-carbon, branded and high-quality”, and has the technical and institutional conditions to develop into low-carbon agricultural product, so this study takes regional brand agricultural products as the representative of low-carbon agricultural products. As a information source to guide the public to consume in the green and low-carbon way, local government can effectively develop the market for low-carbon agricultural products and drive the development of low-carbon agriculture from the demand side.MethodsBased on structural equation model with bootstrap method, this paper focuses on the mechanism of the influence of local government information source characteristics (credibility, professionalism, and attractiveness) on consumers' willingness to purchase low-carbon agricultural products, and explores the mediating role of perceived benefits and perceived risks.ResultsThe following findings are established: first, the credibility and professionalism of local governments play a positive role in influencing the purchase willingness of low-carbon agricultural products through perceived benefits, with credibility having the greatest degree of influence. Second, the attractiveness of local governments positively influences consumers' willingness to purchase low-carbon agricultural products through perceived risk. Third, perceived benefits play a fully mediating role between credibility and purchase intention, play a partially mediating role between professionalism and purchase willingness, perceived risks play a partially mediating role between attractiveness and purchase willingness.DiscussionThis study provides new ideas for the construction of low-carbon agricultural products and low-carbon development in the agricultural sector from the perspective of local government information sources.
Very rapid insight generation to support UK health and care systems: An AHSN approach
Authors: Chandler Jackie , Darnton Philippa , Sibley Andrew 
Published: March 2023

IntroductionCOVID-19 challenges are well documented. Academic Health Science Networks (AHSNs) are a key partner to NHS and care organizations. In response to managing COVID-19 challenges, Wessex AHSN offered rapid insight generation and rapid evaluation to local NHS and care systems to capture learning during this period. This novel “Rapid Insight” approach involved one-off online deliberative events with stakeholders to generate insights linked to specific, priority areas of interest, followed by rapid analysis and dissemination of the findings.ContextKey objectives were to enable system leaders to build their adaptive leadership capability and learn from the experience of COVID-19 to inform recovery planning and system support. Rapid Insight (RI) gathered together health and care professionals into a tightly managed, virtual forum to share system intelligence.ApproachFocused questions asked about the systems' response to the pandemic, what changes to continue and sustain, or discontinue. Participants responded simultaneously to each question using the virtual chat function. Immediate thematic analysis of the chat conducted in 48–72 h by paired analysts for each question strengthened analytical integrity. Mind maps, the key output, provided easily assimilated information and showed linkages between themes. Telephone or virtual interviews of key informants (health and care professionals and patients) and routinely collected data were synthesized into short reports alongside several RI events. However, insufficient time limited the opportunities to engage diverse participants (e.g., mental health users). Data from RI can scope the problem and immediate system needs, to stimulate questions for future evaluative work.ImpactRI facilitated a shared endeavor to discover “clues in the system” by including diverse opinions and experience across NHS and care organizations. Although these rapid virtual events saved on travel time, digital exclusion might constrain participation for some stakeholders which needs other ways to ensure inclusion. Successful rapid engagement required Wessex AHSN's existing system relationships to champion RI and facilitate participant recruitment. RI events “opened the door” to conversations between up to 150 multi-professional clinicians to share their collective response to COVID-19. This paper focuses on the RI approach with a case example and its further development.
Research on the Total Channel Capacities Pertaining to Two Coverage Layouts for Three-Dimensional, UAV-Assisted Ad Hoc Networks
Authors: Yan Xiao , Zhu Shenglong , Wang Qian , Wu Hsiao-Chun 
Published: March 2023

Unmanned aerial vehicles (UAVs) employed as airborne base stations (BSs) are considered the essential components in future sixth-generation wireless networks due to their mobility and line-of-sight communication links. For a UAV-assisted ad hoc network, its total channel capacity is greatly influenced by the deployment of UAV-BSs and the corresponding coverage layouts, where square and hexagonal cells are partitioned to divide the zones individual UAVs should serve. In this paper, the total channel capacities of these two kinds of coverage layouts are evaluated using our proposed novel computationally efficient channel capacity estimation scheme. The mean distance (MD) between a UAV-BS in the network and its served users as well as the MD from these users to the neighboring UAV-BSs are incorporated into the estimation of the achievable total channel capacity. We can significantly reduce the computational complexity by using a new polygon division strategy. The simulation results demonstrate that the square cell coverage layout can always lead to a superior channel capacity (with an average increase of 7.67% to be precise) to the hexagonal cell coverage layout for UAV-assisted ad hoc networks.
Pengaruh Perputaran Total Aset, Likuiditas, Modal kerja, dan Solvabilitas Terhadap Profitabilitas pada Perusahaan Manufaktur yang Terdapat di Bursa Efek Indonesia Periode 2016-2020
Authors: Selly Selly Angel Josephine , Syah Mahmuddin 
Published: March 2023

This research aims to analyze the effect of Total Asset Turnover, Liquidity, Working Capital, and Solvency on Profitability in Manufacturing Companies listed on the Indonesia Stock Exchange in the 2016-2020 period. The method that researcher used in this study is associative quantitative method. The population of this study were 193 manufacturing companies and a sample of 79 data was obtained through purposive sampling with data consisting of 5 years. The results showed that Total Asset Turnover, Liquidity, and Working Capital have significant effect on Profitability in Manufacturing Companies listed on the Indonesia Stock Exchange in 2016-2020. While Solvency has no effect on Profitability in Manufacturing Companies listed on the Indonesia Stock Exchange in 2016-2020.
Keywords : Total Asset Turnover, Liquidity, Working Capital, Solvency, Profitability
Kejadian penyakit kulit di Desa Asir-Asir Asia Kecamatan Lut Tawar Kota Takengon Kabupaten Aceh Tengah
Authors: Januariana Neni Ekowati , Chairi Al 
Published: March 2023

Skin diseases can be caused by several factors, namely living habits and the environment. Skin diseases can develop in personal hygiene and poor environmental hygiene conditions. The diversity of types of skin diseases and the factors that cause skin diseases requires a deeper study of every skin disease phenomenon that occurs in the community. This study aims to determine the factors that cause skin diseases in Asir-Asir Asia Village, Lut Tawar District, Takengon City, Central Aceh Regency. This research was carried out using descriptive analytic in the form ofa survey to determine the factors that cause skin disease in Asir-Asir Asia Village, Lut Tawar District, Takengon City, Central Aceh Regency. The results showed that residents with personal hygiene were 37 people (41.11%) and people with poor personal hygiene were 53 people (58.89%). Respondents who have environmental sanitation by meeting health requirements are 16 people (17.78%) and as many as 74 respondents (82.22%) do not meet health requirements and respondents with the category of having skin disease complaints are observed subjectively and objectively as many as 60 respondents (66.67%) and have no complaints of skin disease as many as 30 respondents (33.33%). The conclusion in this study is that personal hygiene factors have a significant relationship with the incidence of skin disease complaints with a significant value of 0.008 (p < 0.05) and environmental sanitation factors also have a significant relationship with the incidence of skin disease complaints with a significant value of 0.001 (p <0.05).