bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytochrome P450 geneCYP6BQ8mediates terpinen-4-ol susceptibility in the red flour beetle,Tribolium castaneum(Herbst) (Coleoptera: Tenebrionidae)
Authors: Gao Shanshan , Guo Xinlong , Liu Shumei , Li Siying , Zhang Jiahao , Xue Shuang , Tang Qingbo , Zhang Kunpeng , Li Ruimin 
Published: January 2023

AbstractCytochrome P450 proteins (CYPs) in insects can encode various detoxification enzymes and catabolize heterologous substances, conferring tolerance to insecticides. This study describes the identification of a P450 gene (CYP6BQ8) fromTribolium castaneum(Herbst) and investigation of its spatiotemporal expression profile and potential role in the detoxification of terpinen-4-ol, a component of plant essential oils. The developmental expression profile showed thatTcCYP6BQ8expression was relatively higher in early- and late-larval stages ofT. castaneumcompared with other developmental stages. Tissue expression profiles showed thatTcCYP6BQ8was mainly expressed in the head and integument of both larvae and adults. The expression profiling ofTcCYP6BQ8in developmental stages and tissues is closely related to the detoxification of heterologous substances.TcCYP6BQ8expression was significantly induced after exposure to terpinen-4-ol, and RNA interference againstTcCYP6BQ8increased terpinen-4-ol-induced larval mortality from 47.78 to 66.67%. This indicates thatTcCYP6BQ8may be involved inT. castaneum's metabolism of terpinen-4-ol. Correlation investigation between theCYP6BQ8gene and terpinen-4-ol resistance inT. castaneumrevealed that theTcCYP6BQ8gene was one of the factors behindT. castaneum's resistance to terpinen-4-ol. This discovery may provide a new theoretical foundation for future regulation ofT. castaneum.
‘The Black Pit:’ Power and Pitfalls of Digital FDI and Cross-Border Data Flows
Authors: Chaisse Julien 
Published: January 2023

AbstractIn today's data-driven economy, data have been dubbed as the new oil. Hence, a close relationship is shared between the increasing amounts of international investments and the increasing volumes of cross-border data flows. The aim of this article is to discuss the legal aspects of the new data paradigm in the international economy and place this discussion in the larger framework of globalization and the Liberal International Order. The central thesis of the article revolves around the crucial role played by domestic laws in the fragmentation of international investment law. The article further discusses the interplay between national and international legal landscapes and how the changing nature of the Liberal International Order is affecting the flow of data across borders. In this context, it also discusses the issues that are presented by a lack of any comprehensive international framework governing Cross-Border Data Flows. The need to update existing agreements and laws in order to factor in digital investment is also highlighted.
The Right to Hospitality in International Economic Law: Domestic Investment Laws and the Right to Invest
Authors: Dimitropoulos Georgios 
Published: January 2023

AbstractUnder the Liberal International Order (LIO) of the post-WWII years, foreign investment protection was meant to be granted by international law and institutions. But current economic de-globalization is giving way to institutional and legal de-globalization. Domestic laws relating to foreign investment, especially in the form of Domestic Investment Laws, are taking over International Investment Agreements as the standard means of regulating cross-border trade and investment flows. The article compares substantive and procedural standards of investor protection in international and domestic investment law, as well as old and new Domestic Investment Laws, with a focus on non-discrimination and dispute settlement. The move to domestic law in IEL does not always signify a trend for most states to isolate themselves from the international economy. Rather, it is often an effort to achieve similar ends as those of the LIO but using different means. The article discusses an alternative political economy framework for an international (economic) law of ends, the cornerstone of which is the right to hospitality.
Consistent Pattern of Rainfall Asymmetry in Binary Tropical Cyclones
Authors: Liu Hao‐Yan , Gu Jian‐Feng , Wang Yuqing 
Published: January 2023

AbstractThe rainfall distribution in a tropical cyclone (TC) is affected by many factors/processes. Most of previous studies have focused on individual TCs. Little is known about the rainfall distribution in binary TCs. This study examines the rainfall distribution in binary TCs over the western North Pacific based on the observational data. When two TCs become nearby, the asymmetric component of rainfall shows an increasing trend with rainfall significantly suppressed in Quadrant IV of the TC located to the west when orienting the two TCs in the west‐east direction. The suppression becomes remarkable once the separation distance between the two TCs is within about 2,050 km. Furthermore, the convective activity in one TC is related to the deep‐layer vertical wind shear (VWS) from its companion. Rainfall is enhanced downshear‐left in a TC, consistent with a single TC embedded in an environmental VWS as found in previous studies.
Quantitative Evaluation of the Competing Effects of Wastewater Disposal and Hydraulic Fracturing on Causing Induced Earthquakes: A Case Study of an M3.1 Earthquake Sequence in Western Canada
Authors: Wang Bei , Kao Honn , Yu Hongyu , Visser Ryan , Verdecchia Alessandro 
Published: January 2023

AbstractPrevious studies mainly attribute injection‐induced earthquakes (IIE) to hydraulic fracturing (HF) operations in the Western Canada Sedimentary Basin (WCSB), whereas the role of wastewater disposal (WD) has been largely overlooked. One particular reason is that HF operations usually exhibit a clearer spatiotemporal relationship to IIE than WD. However, ignoring the effects from WD when investigating the seismogenisis of IIE in the WCSB may not be appropriate, especially when both types of injection activities are present in the vicinity of the epicentral area. Here, we conduct a case study on an M3.1 earthquake sequence located in the WCSB that can be spatiotemporally correlated with both active HF and WD operations. We first build an enhanced catalog consisting of 256 events to delineate the relationship between the occurrence of IIE and injection history. We then investigate the source parameters of the mainshock in detail. Finally, we build a numerical model to calculate the Coulomb stress change caused by each type of injections on the two nodal planes of the derived focal mechanism. The result suggests that the M3.1 event probably occurred on a near‐horizontal nodal plane. In addition, the pore pressure diffusion from WD and the poroelastic stress transfer from HF could work collaboratively to cause an IIE. Therefore, stress perturbation caused by long‐term WD should also be considered in the seismogenic process of an IIE, especially when both active HF and WD are in the immediate vicinity of the IIE.
Experimental Weathering of Rocks and Minerals at Venus Conditions in the Glenn Extreme Environments Rig (GEER)
Authors: Santos Alison R. , Gilmore Martha S. , Greenwood James P. , Nakley Leah M. , Phillips Kyle , Kremic Tibor , Lopez Xavier 
Published: January 2023

AbstractWe report two experiments using 13 mineral and rock samples exposed to a complex synthetic Venus atmosphere composed of nine gases for durations of 30 and 11 days conducted using the NASA Glenn Extreme Environments Rig (GEER). Examination of our run products using a scanning electron microscope equipped with an energy dispersive spectrometer reveals secondary minerals predominantly formed from reactions of Fe and Ca in the solid samples with sulfur in the atmospheric gas, results largely predicted in the literature, and indicating that such reactions between rocks and the atmosphere at the Venus surface may occur rapidly. Samples that displayed larger degrees of reaction include calcite (forming Ca‐sulfate), Fe‐Ti oxide (forming an Fe,S phase), biotite (forming an Fe,S phase), chalcopyrite (forming a new Cu,Fe‐sulfide and a Ag,Cl phase), and Mid‐Ocean Ridge Basalt glass (forming a Ca‐ and S‐bearing phase, Fe‐ and S‐bearing phase, and an Fe‐oxide); pyrite was observed to be stable in our 30‐day experiment. These reactions indicate that thefS2of the experiments was above or at the high end of what is thermodynamically predicted for the Venus surface. Apatite, feldspars, actinolite, and quartz did not change in this time frame. The presence of multiple S species in the GEER atmosphere may explain the dissimilarities to the style of reactions seen in previous experiments with simpler gas mixtures.
Endoscopic findings in the upper gastrointestinal tract in patients with Crohn’s disease are common, highly specific, and associated with chronic gastritis
Authors: Graca-Pakulska Katarzyna , Błogowski Wojciech , Zawada Iwona , Deskur Anna , Dąbkowski Krzysztof , Urasińska Elżbieta , Starzyńska Teresa 
Published: January 2023

AbstractCrohn’s disease (CD) may affect the entire gastrointestinal tract including its upper part. However, this aspect is poorly addressed in scientific literature and considered a rare finding. Here we aimed to prospectively investigate the prevalence, characteristics and clinical significance of upper gastrointestinal tract involvement in patients with CD, with particular focus on stomach bamboo joint-like appearance (BJA), Helicobacterpylori status and presence of microscopic changes. 375 prospectively recruited patients were included. In CD patients the prevalence of gastric and duodenal, but not esophageal, mucosal lesions, such as gastric mucosal inflammation, duodenal edema, ulcerations, and duodenal bulb deformation was significantly higher (at least p < 0.01 for all). Similar results were found when only H.pylori negative individuals were analyzed. Moreover, BJA of the stomach and in case of H.pylori negative patients also duodenal bulb deformation were detected exclusively in CD patients. Presence of BJA lesion was not significantly associated with neither duration of the disease nor use/history of biologic treatment. Despite absence of H.pylori infection microscopic features of chronic gastritis were found in almost all (93.5%) patients, and in 31% of controls (p < 0.00001). Our analysis outlines that upper gastrointestinal tract involvement in CD is a very common event and frequently manifests with a highly specific BJA lesion. Furthermore, our study reveals that in almost all CD patients features of H.pylori negative gastritis are present.
Optimising remanufacturing decision-making using the bees algorithm in product digital twins
Authors: Kerin Mairi , Hartono Natalia , Pham D. T. 
Published: January 2023

AbstractRemanufacturing is widely recognised as a key contributor to the circular economy (CE) as it extends the in-use life of products, but its synergy with Industry 4.0 (I4.0) has received little attention when compared to manufacturing. An agglomeration of I4.0 technologies and methodologies is reflected in the emerging digital twin (DT) concept, which has been identified as a life-extending enabler. This article captures the design and demonstration of a DT model that optimises remanufacturing planning using data from different instances in a product’s life cycle. The model uses a neural network for remaining useful life predictions and the Bees Algorithm for decision making within a DT. The model is validated using a real case study. The findings support the idea that intelligent tools within a DT can enhance decision-making if they have visibility and access to the product’s current status and reliable remanufacturing process information.
Region-adaptive magnetic resonance image enhancement for improving CNN-based segmentation of the prostate and prostatic zones
Authors: Zaridis Dimitrios I. , Mylona Eugenia , Tachos Nikolaos , Pezoulas Vasileios C. , Grigoriadis Grigorios , Tsiknakis Nikos , Marias Kostas , Tsiknakis Manolis , Fotiadis Dimitrios I. 
Published: January 2023

AbstractAutomatic segmentation of the prostate of and the prostatic zones on MRI remains one of the most compelling research areas. While different image enhancement techniques are emerging as powerful tools for improving the performance of segmentation algorithms, their application still lacks consensus due to contrasting evidence regarding performance improvement and cross-model stability, further hampered by the inability to explain models’ predictions. Particularly, for prostate segmentation, the effectiveness of image enhancement on different Convolutional Neural Networks (CNN) remains largely unexplored. The present work introduces a novel image enhancement method, named RACLAHE, to enhance the performance of CNN models for segmenting the prostate’s gland and the prostatic zones. The improvement in performance and consistency across five CNN models (U-Net, U-Net++, U-Net3+, ResU-net and USE-NET) is compared against four popular image enhancement methods. Additionally, a methodology is proposed to explain, both quantitatively and qualitatively, the relation between saliency maps and ground truth probability maps. Overall, RACLAHE was the most consistent image enhancement algorithm in terms of performance improvement across CNN models with the mean increase in Dice Score ranging from 3 to 9% for the different prostatic regions, while achieving minimal inter-model variability. The integration of a feature driven methodology to explain the predictions after applying image enhancement methods, enables the development of a concrete, trustworthy automated pipeline for prostate segmentation on MR images.
Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes
Authors: Hozumi Kaori , Sugawara Kenji , Ishihara Takaya , Ishihara Naotada , Ogawa Wataru 
Published: January 2023

AbstractImeglimin is a recently launched antidiabetic drug structurally related to metformin. To provide insight into the pharmacological properties of imeglimin, we investigated its effects on hepatocytes and compared them with those of metformin. The effects of imeglimin on mitochondrial function in HepG2 cells or mouse primary hepatocytes were examined with an extracellular flux analyzer and on gene expression in HepG2 cells by comprehensive RNA-sequencing analysis. The effects of the drug on AMPK activity in HepG2 cells, mouse primary hepatocytes, and mouse liver were also examined. Treatment of HepG2 cells or mouse primary hepatocytes with imeglimin reduced the oxygen consumption rate coupled to ATP production. Imeglimin activated AMPK in these cells whereas the potency was smaller than metformin. Bolus administration of imeglimin in mice also activated AMPK in the liver. Whereas the effects of imeglimin and metformin on gene expression in HepG2 cells were similar overall, the expression of genes encoding proteins of mitochondrial respiratory complex III and complex I was upregulated by imeglimin but not by metformin. Our results suggest that imeglimin and metformin exert similar pharmacological effects on mitochondrial respiration, AMPK activity, and gene expression in cultured hepatocytes, whereas the two drugs differ in their effects on the expression of certain genes related to mitochondrial function.
Utilization of temporal autoencoder for semi-supervised intracranial EEG clustering and classification
Authors: Nejedly Petr , Kremen Vaclav , Lepkova Kamila , Mivalt Filip , Sladky Vladimir , Pridalova Tereza , Plesinger Filip , Jurak Pavel , Pail Martin , Brazdil Milan , Klimes Petr , Worrell Gregory 
Published: January 2023

AbstractManual visual review, annotation and categorization of electroencephalography (EEG) is a time-consuming task that is often associated with human bias and requires trained electrophysiology experts with specific domain knowledge. This challenge is now compounded by development of measurement technologies and devices allowing large-scale heterogeneous, multi-channel recordings spanning multiple brain regions over days, weeks. Currently, supervised deep-learning techniques were shown to be an effective tool for analyzing big data sets, including EEG. However, the most significant caveat in training the supervised deep-learning models in a clinical research setting is the lack of adequate gold-standard annotations created by electrophysiology experts. Here, we propose a semi-supervised machine learning technique that utilizes deep-learning methods with a minimal amount of gold-standard labels. The method utilizes a temporal autoencoder for dimensionality reduction and a small number of the expert-provided gold-standard labels used for kernel density estimating (KDE) maps. We used data from electrophysiological intracranial EEG (iEEG) recordings acquired in two hospitals with different recording systems across 39 patients to validate the method. The method achieved iEEG classification (Pathologic vs. Normal vs. Artifacts) results with an area under the receiver operating characteristic (AUROC) scores of 0.862 ± 0.037, 0.879 ± 0.042, and area under the precision-recall curve (AUPRC) scores of 0.740 ± 0.740, 0.714 ± 0.042. This demonstrates that semi-supervised methods can provide acceptable results while requiring only 100 gold-standard data samples in each classification category. Subsequently, we deployed the technique to 12 novel patients in a pseudo-prospective framework for detecting Interictal epileptiform discharges (IEDs). We show that the proposed temporal autoencoder was able to generalize to novel patients while achieving AUROC of 0.877 ± 0.067 and AUPRC of 0.705 ± 0.154.
Influence of rotor excitation source model in electromagnetic field–circuit coupling analysis model of tubular hydro‐generator on no‐load voltage waveform and damper winding loss calculation results
Authors: Gu Shi‐fu , Bian Zu‐ying , Zhou Zhi‐ting , Fan Zhen‐nan , Yang Yong , Li Jing‐can 
Published: January 2023

AbstractIn this study, a 34‐MW tubular hydro‐generator was selected as the study example. For the electromagnetic field–circuit coupling analysis model, the effects of the ideal DC voltage and current sources (i.e. two models of the rotor excitation power supply) on the no‐load voltage waveform quality and the damper winding loss calculation results were studied by considering the influence of the electromagnetic induction of the rotor excitation winding. The obtained results provide direct and effective theoretical support and technical reference for improving the accuracy and rationality of the calculation results of the electromagnetic performance parameters and the analysis, design, manufacturing and operating level of such generators.
On the security of ‘an ultra‐lightweight and secure scheme for communications of smart metres and neighbourhood gateways by utilisation of an ARM Cortex‐M microcontroller’
Authors: Miri Sonia , Kaveh Masoud , Shahhoseini Hadi Shahriar , Mosavi Mohammad Reza , Aghapour Saeed 
Published: January 2023

AbstractIn 2018, Abbasinezhad‐Mood and Nikooghadam (IEEE Transaction on Smart Grid, pp 6194–6205, 9(6), 2018) proposed an ultra‐lightweight secure scheme for neighbourhood area network () communications in smart grid. They have claimed that their protocol is secure against all known attacks in environment by providing informal security analysis besides a formal analysis which was done by using an automatic verification tool. However, by performing several attacks, this study shows that their scheme has serious security flaws. After performing each attack, lightweight countermeasures is proposed for securing their protocol against that attack.
Retracted: Prediction of stock market movement via technical analysis of stock data stored on blockchain using novel History Bits based machine learning algorithm
Authors: Sakhare Nitin Nandkumar , Shaik Imambi S. , Saha Suman 
Published: January 2023

AbstractRetraction: [Nitin Nandkumar Sakhare, Imambi S. Shaik, Suman Saha, Prediction of stock market movement via technical analysis of stock data stored on blockchain using novel History Bits based machine learning algorithm, IET Software 2023 (https://doi.org/10.1049/sfw2.12092)].The above article from IET Software, published online on 12 January 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Hana Chockler, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
Enhancement of Technology in Pedagogy and Practice in Higher Education during Covid-19
Authors: Al Mahdi Zahra 
Published: January 2023

The Spread of new forms of technology has inundated the learning System of the student at all levels, especially the higher education level. The efficacy of teaching students to keep pace with evolution without understanding how they will learn. This is the start of an endless journey. Students are always fascinated by digital gadgets and interact more when they find new things; this is one of the reasons integrating new technologies, and interactive tools is very important in this stage of the learning process.
Adopting technology in higher education is an innovation that does not cause any disruption to traditional learning mechanisms but rather contributes to the learning evolution. Higher education institutions face many challenges when adopting new technology to their pedagogical style and teaching method because of the growing student numbers and the application of these techniques and methods for students from Different categories and timing.
The flipped learning approach we adopted helped us start our Journey smoothly during the Covid 19 pandemic. In continuation to the approach that we adopted of giving students a different and fulfilling learning experience, Middle East College is working on improving the implementation of flipped learning redefined in the context of Online and blended learning.
During this phase, the main aim is to enhance the effectiveness of flipped learning in online teaching in delivering and planning synchronous and asynchronous
Activities. Also, it helps to improve the interaction of the students with the given materials.
This study focuses on enhancing technology in pedagogy and practice in higher education. Where will this study identify the staff member's technological needs and how learning was influenced?
In addition, it will highlight the mechanisms used to facilitate the collaboration and interactions between students and Faculties to improve the learning experience, inspire students to learn in an active environment, and encourage Learning Ownership for Lifelong learning.
Rhodium(III) Iodide Catalyzed Carboamination of Alkynes through C–N Bond Activation
Authors: Xu Tao , Li XinXin , Yang Qingxing , Zhang Yuna 
Published: January 2023

AbstractHere, we report a RhI3-catalyzed intramolecular carboamination reaction to access polysubstituted indoles. The protocol features a broad substrate scope (>20 examples), good functional-group compatibility, and a low catalyst loading (5 mol% Rh). Good to excellent yields (up to 98%) were obtained. An unprecedented C–N bond-cleavage mode via a six-membered transition state σ-bond metathesis mechanism was proposed based on control experiments. A series of C3-allylated indole derivatives were accessed, proving that the system provides an alternative catalytic route to polysubstituted indoles.