bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of the Pipeline Flex embolization device with Shield Technology for the acute treatment of ruptured internal carotid artery pseudoaneurysms: a multi-institution case series
Authors: Bounajem Michael T. , Joyce Evan , Scoville Jonathan P. , Seinfeld Joshua , Hoffman Jessa , Grossberg Jonathan A. , Waiters Vanesha , White Andrew C. , Nerva John , Burkhardt Jan-Karl , Tonetti Daniel A. , El Naamani Kareem , Gooch M. Reid , Jabbour Pascal , Tjoumakaris Stavropoula , Ortega Gutierrez Santiago , Levitt Michael R. , Lang Michael , Ares William J. , Desai Sohum , Mascitelli Justin R. , Kilburg Craig J. , Budohoski Karol P. , Couldwell William T. , Gross Bradley A. , Grandhi Ramesh 
Published: May 2023

OBJECTIVE
Ruptured blister, dissecting, and iatrogenic pseudoaneurysms are rare pathologies that pose significant challenges from a treatment standpoint. Endovascular treatment via flow diversion represents an increasingly popular option; however, drawbacks include the requirement for dual antiplatelet therapy and the potential for thromboembolic complications, particularly acute complications in the ruptured setting. The Pipeline Flex embolization device with Shield Technology (PED-Shield) offers reduced material thrombogenicity, which may aid in the treatment of ruptured internal carotid artery pseudoaneurysms.

METHODS
The authors conducted a multi-institution, retrospective case series to determine the safety and efficacy of PED-Shield for the treatment of ruptured blister, dissecting, and iatrogenic pseudoaneurysms of the internal carotid artery. Clinical, radiographic, treatment, and outcomes data were collected.

RESULTS
Thirty-three patients were included in the final analysis. Seventeen underwent placement of a single device, and 16 underwent placement of two devices. No thromboembolic complications occurred. Four patients were maintained on aspirin alone, and all others were treated with long-term dual antiplatelet therapy. Among patients with 3-month follow-up, 93.8% had a modified Rankin Scale score of 0–2. Complete occlusion at follow-up was observed in 82.6% of patients.

CONCLUSIONS
PED-Shield represents a new option for the treatment of ruptured blister, dissecting, and iatrogenic pseudoaneurysms of the internal carotid artery. The reduced material thrombogenicity appeared to improve the safety of the PED-Shield device, as this series demonstrated no thromboembolic complications even among patients treated with only single antiplatelet therapy. The efficacy of PED-Shield reported in this series, particularly with placement of two devices, demonstrates its potential as a first-line treatment option for these pathologies.
Child’s lawyer in Ukraine
Authors: Yushkevych O. G. 
Published: May 2023

It has been analyzed the opinions of scholars and lawyers on the definition of the concept of “a child’s lawyer”. The author’s definition on the concept of “child’s lawyer” has been formulated, which should be understood as a person who carries out legal activities on the grounds and in accordance with the procedure provided for by law, and which consists in the independent professional activity of a lawyer in the field of defense, representation and provision of other types of legal assistance to a person under 18 years of age (majority). Taking into account the levels of specialization in the bar, it has been established that the specialization “child’s lawyer” can be both at the corporate level (creation of a structural unit in the system of bar self-government bodies responsible for the protection of children’s rights) and at the professional level (the law provides for the practice of the legal profession individually, through a law firm and a law association, which are also engaged in the protection of children's rights). It has been proved that the branch differentiation of law, based on the theory of differentiation of legal relations, is generally accepted for the specialization of Ukrainian lawyers. It has been proposed to distinguish a child as an individual to whom a child’s lawyer provides legal aid, i.e., as a type of a lawyer’s client. It has been noted that Ukrainian legislation operates with special concepts such as “ensuring the best interests of the child”, “child abuse”, “child in difficult life circumstances”, “child in need of additional protection”, “contact with the child”, which are inherent only in cases involving a child.
It has been analyzed the opportunities provided by the Higher School of Advocacy of the National Bar Association of Ukraine for obtaining the specialization of a child lawyer. In order to develop the idea and unite the relevant lawyer community “child lawyer”, lawyers are being certified, a register of child lawyers is being maintained, and specialists are constantly deepening their thematic specialization and providing information and support.
It has been analyzed the experience of other countries regarding the use in practice of the concepts of “child’s lawyer” in family courts, “child protection advocacy” and established the requirements for a child’s lawyer.
Criminological typology of radical criminals among sentenced to imprisonment
Authors: Danylchenko P. Yu. 
Published: May 2023

The article is devoted to the study of radical criminals among those sentenced to imprisonment. The purpose of the article is to provide a criminological typological characteristic of criminal radicals among those sentenced to imprisonment. The following tasks have been solved to achieve this goal: 1) to define the typological criteria for the division of criminal radicals among those sentenced to imprisonment; 2) to identify the relevant criminological types according to the criteria; 3) to identify and describe the signs of criminological types of criminal radicals among those sentenced to imprisonment.
It has been proposed that 7 typological personal criteria should be used in scientific use and practical criminal prevention activities: by nature, by the direction of criminal and radical actions, by the contextual element of personal radicalisation, by the source of radical attitude, by the peculiarities of the radical’s predicate state, by the existential content of criminal and radical behaviour, and by the dominant social and role feature. According to them, 22 criminological types (including subtypes) of criminal radicals among convicts were identified. The author describes the key criminologically significant features of each type. The integrated typological characteristics of radical criminals among convicts give grounds to note that most of them can be correlated with an initiative, aggressive, rational-conformist, collectivist radical of an inclusive type.
Both the initial diagnostic work of the relevant units and officials of the quarantine, diagnostic and distribution sectors of correctional colonies, as well as the further work of social and psychological work inspectors, should be aimed at identifying and recording these features. It has been argued that this information should also be taken into account when organising and carrying out operational work among prisoners in order to block the development of motivations for radical actions in a timely manner and to stop the tendencies of radicalisation among prisoners.
It has been noted that the proposed typology of criminal radicals in penitentiary institutions is not closed, exhaustive, and can be supplemented with other criteria and types depending on the researcher's target setting and a specific applied request in the field of prevention of criminal radical manifestations in penitentiary institutions.
A Re-Imagined Institutional Student Retention and Success Framework to Enhance Holistic Student Support
Authors: Brown Vanessa , Pather Sabetra , Lawack Vivienne 
Published: May 2023

The focus on student retention and success is a core concern at higher education institutions world-wide. In the South African higher education system, the widening of access, high attrition, low throughput and low completion rates highlight the vast disparities with students entering university. Student diversity with regard to prior contexts influences the way students engage in the higher education environment. In addition, many South African universities are equally not prepared to cater for the diverse needs of their students. This paper highlights the development and implementation of a holistic institutional student retention and success framework. The framework places the student as the central focus and the institution as a key role player in supporting student retention and success. Quantitative and qualitative data were used to inform the development of the student retention and success framework. Data were collected from a cohort of students over a seven-year period (2010 to 2017). A trend analysis was conducted with 4 547 students, using quantitative data from the university management system; in 2017 qualitative data were collected from a purposively selected sample of 54 students to gain an in-depth understanding of how students navigate their university studies within the university systems. Bertalanffy’s general systems theory (GST) was used to analyse the data and bring into focus the significance of the interdependence and interrelatedness of systems, and structures which influence each other directly or indirectly. In the framework the phenomenon of student success is viewed holistically as a set of elements interacting with one another within the university as a system. The paper argues that each element in the framework has an important role to play in providing holistic student support, engagement and success.
Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection
Authors: Huang Shi-Mei , Tang Yu-Rong , Wang Ji-Liang , Wang Xiao-Zhen , Zhang Yuan-Yuan , Pan Su-Fei 
Published: May 2023

BackgroundExtra-urogenital infections due to Mycoplasma hominis (M. hominis) are rare, particularly co-infection with Pseudomonas aeruginosa (P. aeruginosa). Herein, we report on a patient who was co-infected and successfully treated despite delayed treatment.Case presentationWe reported the case of a 43-year-old man with M. hominis and P. aeruginosa co-infection after a traffic accident. The patient developed a fever and severe infection despite postoperative antimicrobial therapies. The blood culture of wound tissues was positive for P. aeruginosa. Meanwhile, culturing of blood and wound samples showed pinpoint-sized colonies on blood agar plates and fried-egg-type colonies on mycoplasma medium, which were identified as M. hominis by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rRNA sequencing. Based on antibiotic susceptibility and symptoms, ceftazidime–avibactam and moxifloxacin were administered for P. aeruginosa infection. Meanwhile, after the failure of a series of anti-infective agents, M. hominis and P. aeruginosa co-infection was successfully treated with a minocycline-based regimen and polymyxin B.ConclusionThe co-infection with M. hominis and P. aeruginosa was successfully treated with anti-infective agents despite delayed treatment, providing information for the management of double infection.
HBV reactivation and its effect on survival in HBV-related hepatocarcinoma patients undergoing transarterial chemoembolization combined with tyrosine kinase inhibitors plus immune checkpoint inhibitors
Authors: Shen Jiaming , Wang Xia , Wang Ningning , Wen Shifei , Yang Guangde , Li Li , Fu Juanjuan , Pan Xiucheng 
Published: May 2023

ObjectiveThis study aimed to access hepatitis B virus (HBV) reactivation and its effect on survival in HBV-related hepatocarcinoma (HCC) patients who underwent transarterial chemoembolization (TACE) combined with tyrosine kinase inhibitors (TKIs) plus immune checkpoint inhibitors (ICIs).MethodsIn this single-center retrospective study, we enrolled 119 HBV-related unresectable advanced HCC patients receiving TACE combined with TKIs plus ICIs. Risk factors for HBV reactivation were analyzed by logistic regression. Kaplan-Meier method was applied to draw the survival curve, and log-rank test was used to compare survival between patients with and without HBV reactivation.ResultsA total of 12 patients (10.1%) encountered HBV reactivation in our study, of which only 4 patients received antiviral prophylaxis. The incidence of HBV reactivation was 1.8% (1/57) in patients with detectable baseline HBV DNA and 4.2% (4/95) in patients with antiviral prophylaxis respectively. Lack of prophylactic antiviral treatment (OR=0.047, 95%CI 0.008-0.273, P=0.001) and undetectable HBV DNA (OR=0.073, 95%CI 0.007-0.727, P=0.026) were independent risk factors for HBV reactivation. The median survival time (MST) for all patients was 22.4 months. No survival difference was observed in patients with or without HBV reactivation. (MST: undefined vs 22.4 months, log-rank test: P=0.614).ConclusionHBV reactivation could occur in HBV-related HCC patients who treated with TACE in combination with TKIs plus ICIs. Before and during the combination treatment, it is necessary to routinely monitor HBV DNA and to take effective prophylactic antiviral therapy.
Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the NK function in Hu-BLT mice
Authors: Kaur Kawaljit , Chen Po-Chun , Ko Meng-Wei , Mei Ao , Senjor Emanuela , Malarkannan Subramaniam , Kos Janko , Jewett Anahid 
Published: May 2023

Introduction and methodsIn this study we report that sequential treatment of supercharged NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both poorly differentiated and well differentiated tumors in-vivo in humanized-BLT mice.Background and resultssNK cells were found to be a unique population of activated NK cells with genetic, proteomic, and functional attributes that are very different from primary untreated or IL-2 treated NK cells. Furthermore, NK-supernatant differentiated or well-differentiated oral or pancreatic tumor cell lines are not susceptible to IL-2 activated primary NK cell-mediated cytotoxicity; however, they are greatly killed by the CDDP and paclitaxel in in-vitro assays. Injection of one dose of sNK cells at 1 million cells per mouse to aggressive CSC-like/poorly differentiated oral tumor bearing mice, followed by an injection of CDDP, inhibited tumor weight and growth, and increased IFN-γ secretion as well as NK cell-mediated cytotoxicity substantially in bone marrow, spleen and peripheral blood derived immune cells. Similarly, the use of check point inhibitor anti-PD-1 antibody increased IFN-γ secretion and NK cell-mediated cytotoxicity, and decreased the tumor burden in-vivo, and tumor growth of resected minimal residual tumors from hu-BLT mice when used sequentially with sNK cells. The addition of anti-PDL1 antibody to poorly differentiated MP2, NK-differentiated MP2 or well-differentiated PL-12 pancreatic tumors had different effects on tumor cells depending on the differentiation status of the tumor cells, since differentiated tumors expressed PD-L1 and were susceptible to NK cell mediated ADCC, whereas poorly differentiated OSCSCs or MP2 did not express PD-L1 and were killed directly by the NK cells.ConclusionsTherefore, the ability to target combinatorially clones of tumors with NK cells and chemotherapeutic drugs or NK cells with checkpoint inhibitors at different stages of tumor differentiation may be crucial for successful eradication and cure of cancer. Furthermore, the success of check point inhibitor PD-L1 may relate to the levels of expression on tumor cells.
High opsonic phagocytosis activity and growth inhibition of merozoites are associated with RON4 antibody levels and protect against febrile malaria in Ghanaian children
Authors: Kyei-Baafour Eric , Kusi Kwadwo Asamoah , Arthur Fareed K.N. , Tiendrebeogo Regis W. , Owusu-Yeboa Eunice , Singh Susheel K. , Friedrich Sarah , Gerds Thomas A. , Dodoo Daniel , Theisen Michael , Adu Bright 
Published: May 2023

BackgroundNaturally acquired immunity to malaria may involve different immune mechanisms working in concert, however, their respective contributions and potential antigenic targets have not been clearly established. Here, we assessed the roles of opsonic phagocytosis and antibody-mediated merozoite growth inhibition in Plasmodium falciparum (P. falciparum) infection outcomes in Ghanaian children.MethodsThe levels of merozoite opsonic phagocytosis, growth inhibition activities and six P. falciparum antigen-specific IgG of plasma samples from children (n=238, aged 0.5 to 13 years) were measured at baseline prior to the malaria seasons in southern Ghana. The children were then actively and passively followed up for febrile malaria and asymptomatic P. falciparum infection detection in a 50-week longitudinal cohort. P. falciparum infection outcome was modelled as a function of the measured immune parameters while accounting for important demographic factors.ResultsHigh plasma activity of opsonic phagocytosis [adjusted odds ratio (aOR)= 0.16; 95%CI= 0.05 - 0.50, p = 0.002], and growth inhibition (aOR=0.15; 95% CI = 0.04-0.47; p = 0.001) were individually associated with protection against febrile malaria. There was no evidence of correlation (b= 0.13; 95% CI= -0.04-0.30; p=0.14) between the two assays. IgG antibodies against MSPDBL1 correlated with opsonic phagocytosis (OP) while IgG against PfRh2a correlated with growth inhibition. Notably, IgG antibodies against RON4 correlated with both assays.ConclusionOpsonic phagocytosis and growth inhibition are protective immune mechanisms against malaria that may be acting independently to confer overall protection. Vaccines incorporating RON4 may benefit from both immune mechanisms.
Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease
Authors: Liu Xueying , Miao Yahu , Liu Chao , Lu Wan , Feng Qing , Zhang Qiu 
Published: May 2023

BackgroundAutoimmune thyroid disease (AITD) is induced by various factors, including inheritability, which regulates gene expression. Multiple loci correlated with AITD have been discovered utilizing genome-wide association studies (GWASs). Nevertheless, demonstrating the biological relevance and function of these genetic loci is difficult.MethodsThe FUSION software was utilized to define genes that were expressed differentially in AITD using a transcriptome-wide association study (TWAS) method in accordance with GWAS summary statistics from the largest genome-wide association study of 755,406 AITD individuals (30,234 cases and 725,172 controls) and levels of gene expression from two tissue datasets (blood and thyroid). Further analyses were performed such as colocalization, conditional, and fine-mapping analyses to extensively characterize the identified associations, using functional mapping and annotation (FUMA) to conduct functional annotation of the summary statistics of 23329 significant risk SNPs (P &lt; 5 × 10−8) recognized by GWAS, together with summary-data-based mendelian randomization (SMR) for identifying functionally related genes at the loci in GWAS.ResultsThere were 330 genes with transcriptome-wide significant differences between cases and controls, and the majority of these genes were new. 9 of the 94 unique significant genes had strong, colocalized, and potentially causal correlations with AITD. Such strong associations included CD247, TPO, KIAA1524, PDE8B, BACH2, FYN, FOXK1, NKX2-3, and SPATA13. Subsequently, applying the FUMA approach, novel putative AITD susceptibility genes and involved gene sets were detected. Furthermore, we detected 95 probes that showed strong pleiotropic association with AITD through SMR analysis, such as CYP21A2, TPO, BRD7, and FCRL3. Lastly, we selected 26 genes by integrating the result of TWAS, FUMA, and SMR analysis. A phenome-wide association study (pheWAS) was then carried out to determine the risk of other related or co-morbid phenotypes for AITD-related genes.ConclusionsThe current work provides further insight into widespread changes in AITD at the transcriptomic level, as well as characterized the genetic component of gene expression in AITD by validating identified genes, establishing new correlations, and uncovering novel susceptibility genes. Our findings indicate that the genetic component of gene expression plays a significant part in AITD.
Survival analysis and prognosis of patients with breast cancer with pleural metastasis
Authors: Li Sumei , Li Chao , Shao Wenna , Liu Xiaoyu , Sun Luhao , Yu Zhiyong 
Published: May 2023

BackgroundBreast cancer (BC) is the most common malignant cancer. The prognosis of patients differs according to the location of distant metastasis, with pleura being a common metastatic site in BC. Nonetheless, clinical data of patients with pleural metastasis (PM) as the only distant metastatic site at initial diagnosis of metastatic BC (MBC) are limited.Patient cohort and methodsThe medical records of patients who were hospitalized in Shandong Cancer Hospital between January 1, 2012 and December 31, 2021 were reviewed, and patients eligible for the study were selected. Survival analysis was conducted using Kaplan–Meier (KM) method. Univariate and multivariate Cox proportional-hazards models were used to identify prognostic factors. Finally, based on these selected factors, a nomogram was constructed and validated.ResultsIn total, 182 patients were included; 58 (group A), 81 (group B), and 43 (group C) patients presented with only PM, only lung metastasis (LM), and PM combined with LM, respectively. The KM curves revealed no significant difference in overall survival (OS) among the three groups. However, in terms of survival after distant metastasis (M-OS), the difference was significant: patients with only PM exhibited the best prognosis, whereas those with PM combined with LM exhibited the worst prognosis (median M-OS: 65.9, 40.5, and 32.4 months, respectively; P = 0.0067). For patients with LM in groups A and C, those with malignant pleural effusion (MPE) exhibited significantly worse M-OS than those without MPE. Univariate and multivariate analyses indicated that primary cancer site, T stage, N stage, location of PM, and MPE were independent prognostic factors for patients with PM without other distant metastasis. A nomogram prediction model incorporating these variables was created. According to the C-index (0.776), the AUC values of the 3-, 5-, and 8-year M-OS (0.86, 0.86, and 0.90, respectively), and calibration curves, the predicted and actual M-OS were in good agreement.ConclusionBC patients with PM only at the first diagnosis of MBC exhibited a better prognosis than those with LM only or PM combined with LM. We identified five independent prognostic factors associated with M-OS in this subset of patients, and a nomogram model with good predictive efficacy was established.