bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Tafamidis With Health Status in Patients With ATTR Cardiac Amyloidosis
Authors: Sperry Brett W. , Hanna Mazen , Maurer Mathew S. , Nativi-Nicolau Jose , Floden Lysbeth , Stewart Michelle , Wyrwich Kathleen W. , Barsdorf Alexandra I. , Kapadia Heli , Spertus John A. 
Published: February 2023

ImportanceTafamidis reduced all-cause mortality and cardiovascular-related hospitalizations and minimized patient-reported health status deterioration at 30 months in patients with transthyretin (ATTR) amyloidosis. However, the clinical significance of health status changes remains unclear, particularly in patients with New York Heart Association (NYHA) class III symptoms who experienced more cardiovascular-related hospitalizations than those with NYHA class I-II symptoms.ObjectiveTo evaluate the health status of patients taking tafamidis with baseline NYHA class III symptoms.Design, Setting, and ParticipantsThis randomized clinical trial post hoc analysis evaluated data for patients with transthyretin (ATTR) cardiac amyloidosis and NYHA class I-III symptoms at baseline who were enrolled in ATTR-ACT, a placebo-controlled study of tafamidis held at 48 sites in 13 countries.InterventionsTafamidis meglumine, 80 mg or 20 mg (pooled cohort), vs placebo.Main Outcomes and MeasuresEstablished thresholds for clinical benefit on the Kansas City Cardiomyopathy Questionnaire Overall Summary (KCCQ-OS) were used to define response groups (very large decline to very large improvement); the proportion of patients in each group was calculated within each baseline NYHA class.ResultsAmong 441 patients (264 tafamidis, 177 placebo), the mean (SD) age was 74.3 (7.0) years; 398 (90%) were male and 43 (10%) were female. Mean (SD) baseline KCCQ-OS scores were 67.3 (21.4) in the tafamidis group and 65.9 (21.7) in the placebo group (range: 0-100, with 100 indicating the best health). There was a significant shift toward better KCCQ-OS scores in patients receiving tafamidis (odds ratio for 10-point improvement 2.4; 95% CI, 1.6-3.4; P &amp;lt; .001). More patients taking tafamidis were alive and not worse at all time points (37% vs 15% at month 30). These findings were similar in patients with NYHA class III symptoms. In patients with NYHA class III symptoms alive at 30 months, improvements in health status were more common (35% vs 10%) and declines were less common (38% vs 57%) with tafamidis vs placebo.Conclusions and RelevanceIn ATTR-ACT, although patients with baseline NYHA class III symptoms had worse overall outcomes, treatment with tafamidis yielded better health status compared with placebo.Trial RegistrationClinicalTrials.gov Identifier: NCT01994889
Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease
Authors: Dron Jacqueline S. , Patel Aniruddh P. , Zhang Yiyi , Jurgens Sean J. , Maamari Dimitri J. , Wang Minxian , Boerwinkle Eric , Morrison Alanna C. , de Vries Paul S. , Fornage Myriam , Hou Lifang , Lloyd-Jones Donald M. , Psaty Bruce M. , Tracy Russell P. , Bis Joshua C. , Vasan Ramachandran S. , Levy Daniel , Heard-Costa Nancy , Rich Stephen S. , Guo Xiuqing , Taylor Kent D. , Gibbs Richard A. , Rotter Jerome I. , Willer Cristen J. , Oelsner Elizabeth C. , Moran Andrew E. , Peloso Gina M. , Natarajan Pradeep , Khera Amit V. 
Published: February 2023

ImportanceProtein-truncating variants (PTVs) in apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with significantly lower low-density lipoprotein (LDL) cholesterol concentrations. The association of these PTVs with coronary heart disease (CHD) warrants further characterization in large, multiracial prospective cohort studies.ObjectiveTo evaluate the association of PTVs in APOB and PCSK9 with LDL cholesterol concentrations and CHD risk.Design, Setting, and ParticipantsThis studied included participants from 5 National Heart, Lung, and Blood Institute (NHLBI) studies and the UK Biobank. NHLBI study participants aged 5 to 84 years were recruited between 1971 and 2002 across the US and underwent whole-genome sequencing. UK Biobank participants aged 40 to 69 years were recruited between 2006 and 2010 in the UK and underwent whole-exome sequencing. Data were analyzed from June 2021 to October 2022.ExposuresPTVs in APOB and PCSK9.Main Outcomes and MeasuresEstimated untreated LDL cholesterol levels and CHD.ResultsAmong 19 073 NHLBI participants (10 598 [55.6%] female; mean [SD] age, 52 [17] years), 139 (0.7%) carried an APOB or PCSK9 PTV, which was associated with 49 mg/dL (95% CI, 43-56) lower estimated untreated LDL cholesterol level. Over a median (IQR) follow-up of 21.5 (13.9-29.4) years, incident CHD was observed in 12 of 139 carriers (8.6%) vs 3029 of 18 934 noncarriers (16.0%), corresponding to an adjusted hazard ratio of 0.51 (95% CI, 0.28-0.89; P = .02). Among 190 464 UK Biobank participants (104 831 [55.0%] female; mean [SD] age, 57 [8] years), 662 (0.4%) carried a PTV, which was associated with 45 mg/dL (95% CI, 42-47) lower estimated untreated LDL cholesterol level. Estimated CHD risk by age 75 years was 3.7% (95% CI, 2.0-5.3) in carriers vs 7.0% (95% CI, 6.9-7.2) in noncarriers, corresponding to an adjusted hazard ratio of 0.51 (95% CI, 0.32-0.81; P = .004).Conclusions and RelevanceAmong 209 537 individuals in this study, 0.4% carried an APOB or PCSK9 PTV that was associated with less exposure to LDL cholesterol and a 49% lower risk of CHD.
Risk of Reoperation for Recurrence After Elective Primary Groin and Ventral Hernia Repair by Supervised Residents
Authors: Christophersen Camilla , Fonnes Siv , Andresen Kristoffer , Rosenberg Jacob 
Published: February 2023

ImportanceSurgical training involves letting residents operate under supervision. Since hernia repair is a common procedure worldwide, it is a frequent part of the surgical curriculum.ObjectiveTo assess the risk of reoperation for recurrence after elective primary groin and ventral hernia repair performed by supervised residents compared with that by specialists.Design, Setting, and ParticipantsThis nationwide register-based cohort study included data from January 2016 to September 2021. Patients were followed up until reoperation, emigration, death, or the end of the study period. The study used data from the Danish Inguinal and Ventral Hernia Databases linked with data from the Danish Patient Safety Authority’s Online Register via surgeons’ unique authorization ID.The cohort included patients aged 18 years or older who underwent primary elective hernia repairs performed by supervised residents or specialists for inguinal, femoral, epigastric, or umbilical hernias. Hernia repairs were divided into the following 4 groups: Lichtenstein groin, laparoscopic transabdominal preperitoneal (TAPP) groin, open ventral, and laparoscopic ventral.ExposuresHernia repairs performed by supervised residents vs specialists.Main Outcomes and MeasuresReoperation for recurrence, analyzed separately for all 4 groups.ResultsA total of 868 specialists and residents who performed 31 683 primary groin and 7777 primary ventral hernia repairs were included in this study. The median age of patients who underwent hernia repair was 60 years (IQR, 48-70 years), and 33 424 patients (84.7%) were male. There was no significant difference in the adjusted risk of reoperation after Lichtenstein groin hernia repair (hazard ratio [HR], 1.26; 95% CI, 0.99-1.59), laparoscopic groin hernia repair (HR, 1.01; 95% CI, 0.73-1.40), open ventral hernia repair (HR, 0.89; 95% CI, 0.61-1.29), and laparoscopic ventral hernia repair (HR, 2.96; 95% CI, 0.99-8.84) performed by supervised residents compared with those by specialists. There was, however, a slightly increased unadjusted, cumulative reoperation rate after Lichtenstein repairs performed by supervised residents compared with those by specialists (4.8% vs 4.2%; P = .048).Conclusions and RelevanceThe findings of this study suggest that neither open nor laparoscopic repair of groin and ventral hernias performed by supervised residents appeared to be associated with a higher risk of reoperation for recurrence compared with the operations performed by specialists. This indicates that residents may safely perform elective hernia repair when supervised as part of their training curriculum.
Constructing Superhydrophobicity by Self‐Assembly of SiO2@Polydopamine Core‐Shell Nanospheres with Robust Oil‐Water Separation Efficiency and Anti‐Corrosion Performance
Authors: Shi Zhen , Zeng Hang , Yuan Yusheng , Shi Nan , Wen Lin , Rong Huawei , Zhu Dapeng , Hu Liang , Ji Lianze , Zhao Lizhong , Zhang Xuefeng 
Published: January 2023

AbstractVulnerable robustness of superhydrophobic materials have mightily hindered their practical applications. Herein, a controllable and effective strategy is demonstrated for constructing robust superhydrophobicity with aqueous hydrophobic interaction driving self‐assembly (HIDS), using polydopamine (PDA) as the binder and SiO2particles as the nano‐sized structures to enable low‐adhesive property. The proposed strategy realizes the rapid interfacial assembly of PDA by manipulating the wetting properties of SiO2@PDA core‐shell particles with hydrophobic modifier. The polyurethane (PU) sponges are facilely rendered superhydrophobic with remarkable robustness, stemming from the excellent adherence of HIDS enhanced covalent interaction between PDA and PU. Coated sponge possesses ultralong‐term stability during the oil‐water separation, the separation efficiency can be maintained at 98.8% even after 1000 cycle separations and strikingly, superhydrophobicity is still retained after 100 cycle abrasion with ultrahigh loading pressure of 49 kPa. Versatilely, the coatings can be assembled on various substrates through scalable dip coating for attaining superhydrophobicity, regardless of size, roughness, chemistry, and rigidity. The complete water‐repellent coatings on permanent magnet of Nd‐Fe‐B hold excellent anti‐corrosion properties without deteriorating the magnetic properties, exhibiting a low corrosion current density of 2.03 × 10−8 A cm−2, which is three orders of magnitude lower than that of 1.30 × 10−5 A cm−2for bare Nd‐Fe‐B magnet.
Ultrathin Wood‐Derived Conductive Carbon Composite Film for Electromagnetic Shielding and Electric Heating Management
Authors: Ma Xiaofan , Pan Junjie , Guo Hongtao , Wang Jingwen , Zhang Chunmei , Han Jingquan , Lou Zhichao , Ma Chunxin , Jiang Shaohua , Zhang Kai 
Published: January 2023

AbstractRecently, wood‐based composites have absorbed widespread concern in the field of electromagnetic interference (EMI) shielding due to their sustainability and inherent layered porous structure. The channel structure of wood is often used to load highly conductive materials to improve the EMI shielding performance of wood‐based composites. However, there is little research on how to use pure wood to prepare ultrathin EMI shielding materials. Herein, ultrathin veneer is obtained by cutting wood in parallel to the annual rings. Then, carbonized wood film (CWF) is prepared by a simple two‐step compressing and carbonization. The specific EMI shielding effectiveness (SSE/t) of CWF‐1200 with an ultrathin thickness (140 µm) and high electrical conductivity (58 S cm−1) can reach 9861.41 dB cm2 g−1, which is much higher than other reported wood‐based materials. In addition, the zeolitie imidazolate framework‐8 (ZIF‐8) nanocrystals are grown in situ on the surface of the CWF to obtain CWF/ZIF‐8. CWF/ZIF‐8 exhibits an EMI shielding effectiveness (SE) of up to 46 dB and an ultrahigh SSE/t value of 11 330.04 dB cm2 g−1 in X band. In addition, the ultrathin CWF also shows an excellent Joule heating effect. Therefore, the development of ultrathin wood‐based film provides a research basis for wood biomass to replace traditional non‐renewable and expensive electromagnetic (EM) shielding materials.
Bio‐Voltage Memristors: From Physical Mechanisms to Neuromorphic Interfaces
Authors: Wang Saisai , Wang Rui , Cao Yaxiong , Ma Xiaohua , Wang Hong , Hao Yue 
Published: January 2023

AbstractWith the rapid development of emerging artificial intelligence technology, brain–computer interfaces are gradually moving from science fiction to reality, which has broad application prospects in the field of intelligent robots. Looking for devices that can connect and communicate with living biological tissues is expected to realize brain–computer interfaces and biological integration interfaces. Brain‐like neuromorphic devices based on memristors may have profound implications for bridging electronic neuromorphic and biological nervous systems. Ultra‐low working voltage is required if memristors are to be connected directly to biological nerve signals. Therefore, inspired by the high‐efficient computing and low power consumption of biological brain, memristors directly driven by the electrical signaling requirements of biological systems (bio‐voltage) are not only meaningful for low power neuromorphic computing but also very suitable to facilitate the integrated interactions with living biological cells. Herein, attention is focused on a detailed analysis of a rich variety of physical mechanisms underlying the various switching behaviors of bio‐voltage memristors. Next, the development of bio‐voltage memristors, from simulating artificial synaptic and neuronal functions to broad application prospects based on neuromorphic computing and bio‐electronic interfaces, is further reviewed. Furthermore, the challenges and the outlook of bio‐voltage memristors over the research field are discussed.
Behavioral agricultural economics
Authors: Wuepper David , Bukchin‐Peles Shira , Just David , Zilberman David 
Published: January 2023

AbstractAgricultural and other fields of economics have always co‐evolved and benefitted from each other's insights. Over time, a general convergence of all social sciences began, and various fields of psychology, sociology, anthropology, and political science started to overlap with general and agricultural economics. Within economics, it was especially the rise of behavioral economics, that has steered the field toward the other social sciences. It departs from the assumption of perfectly rational expected utility maximizers and allows for greater diversity in decision‐makers' objectives and constraints. Agricultural economics has been early to recognize the need to make economic choice models more realistic. This can be explained by the particularities of agricultural economics and agriculture. Agricultural economists are tasked with solving specific, practical problems, and thus behavioral deviations from model predictions have always been salient and relevant to policy recommendations. Then, farmers—and to some extent also consumers—make choices in particularly complex and uncertain environments and must use all strategic tools at their disposal to deal with their “bounded rationality”. These include the reliance on culture and other heuristics. Agricultural economics continues to synergize economic theory and practice with insights from other disciplines and real‐world experiences and is an important driver towards further unification of all social sciences.
Structural and flow properties of polysulfone/magnetic carbon nanomaterials under magnetic field induction
Authors: Xu Jin , Yu Yinrui , He Yan 
Published: January 2023

AbstractMagnetic carbon nanomaterial (MCN) was prepared by hydrothermal method using microfluidic mixing of ferric tetroxide solution precursors, which was added into casting membrane solution, and magnetic polysulfone (PSF) composite membranes were prepared by phase inversion process after introducing an external magnetic field to treat the casting membrane solution. Microscope image depicts Fe3O4 nanoparticles are uniformly loaded on carbon nanomaterials composed of graphene oxide and carbon nanotubes, and the MCN was obtained with less agglomeration, less Fe2O3 impurities, and magnetization intensity of 53.17 emu/g, which is slightly lower than that of pure Fe3O4 (68.72 emu·g−1). Microscopic cross‐sectional view of the membranes indicate the support pore structure still keep a finger‐shaped pore structure but the surface roughness of composite membrane shows an increase in Ra value compared with the pristine PSF (6.23 nm). The hydrophilicity of membranes show a marked improvement increased in contact angle (from 73.158° to 51.854°), which effect the water flux (from 638.49 to 1089.81 L·m−2·h−1) and permeability (from 1.42 to 2.57 μm2), while the effective diameter of pore in membranes increase (from 1.3385 to 1.9078 μm) through bubble pressure method, and the rejection of bovine albumin decrease slightly (from 93.03% to 90.13%), but the values all reach over 90%, which show good permeate separation performance.
Materials Nanoarchitectonics for Advanced Physics Research
Authors: Ariga Katsuhiko 
Published: January 2023

AbstractNanoarchitectonics combines nanotechnology with existing fields such as organic chemistry, supramolecular chemistry, materials science, microfabrication, and bio‐chemistry. It is a concept to create the architecture of atoms, molecules, nanomaterials, and other units for use in functional material systems through various processes. Structural control through nanoarchitectonics can contribute to a variety of fields for advanced physical research. New physical properties can be controlled by forming atomic arrangements, molecular designs, polymer syntheses, crystal structures, self‐assembled structures, and superstructures. Construction of nanospace structures can also elucidate the specific physical properties of molecules trapped in them. Thus, nanoarchitectonics has great potential to contribute to advanced physical research. This paper will discuss some perspectives, categorizing the examples into those that focus on structure formation, those related to optical and photonic functions, those that exploit electronic and electrical properties, and those oriented toward device applications. The presented examples ensure significant contribution of nanoarchitectonics to advanced physical research.
Thermal, structural, optical, and photon shielding studies of cerium‐doped barium tellurite glasses
Authors: Grover Jatin , Kaur Sandeep , Pandey Om Parkash 
Published: January 2023

AbstractA series of tellurite‐based glasses are prepared by using a melt‐quenching method. The effect of cerium on the physical, thermal, structural, optical, spectroscopic, and shielding properties of barium tellurite glass samples is studied. It has been observed that the thermal stability factor increases with increasing cerium ion (Ce3+) concentration. The density and other physical parameters such as ion concentration and molar volume are calculated using the Archimedes principle. An increase in optical band gap and density suggests a decrement in non‐bridging oxygens. These results are in accordance with Raman results. The blue emission in prepared glasses is studied in terms of International Commission on Illumination chromaticity coordinates. Moreover, various shielding properties such as mass attenuation coefficient, linear attenuation coefficient, effective atomic number, half‐value layer, and tenth‐value layer have also been determined to understand the photon shielding characteristics of as‐prepared glass samples.
Survival disadvantage of male children with retinoblastoma in the United States: Surveillance Epidemiology and End Results (2000–2017) Evidence
Authors: Holmes Laurens , Pollack Emily , Berice Betyna N. , Halloran Daniel R. , Parson Kadedrah , Badfford Nastocia T. , Paleaz Lavisha , Benson Jacqueline A. 
Published: January 2023

AbstractBackgroundRetinoblastoma is a rare malignancy involving the retina, although, more common among children, with genetic inheritance explaining the incidence as well as acquired forms. The incidence varies among race and sex as well as mortality and survival. The current study aimed to assess retinoblastoma cumulative incidence (CMI), mortality, and survival by sex.MethodsA retrospective cohort design was used to assess the CMI, mortality, and survival in this pediatric malignancy based on the Surveillance Epidemiology and End Results (SEER) data 2000–2017. The binomial regression model was used to examine sex differentials in mortality, as well as other study variables, while Cox proportional hazard model was used for the survival variability by sex.ResultsThe CMI during this period was higher among males relative to females (males n = 249, 56.7%; females n = 190, 43.3%, χ2 = 2.90, df = 1, p = 0.089). There were sex differences in mortality, with excess mortality observed among males compared to females, risk ratio = 3.40, 95% CI [1.0–15.72]. The survival differences by sex indicated decreased survival among males relative to females, hazard ratio (HR) = 3.39, 95% CI [1.0–15.72]. After controlling for the potential confoundings, namely tumor grade, urbanity, and median income the survival disadvantage of males persisted. Compared to females’, males were more than three times as likely to die, adjusted HR = 3.42, 99% CI [0.37–31.60].ConclusionIn a representative sample of pediatric retinoblastoma, there was a sex differential in survival with excess risk of dying identified among males relative to females, which may be explained in part by male X‐linkage.
Accurate prostate cancer detection based on enrichment and characterization of prostate cancer specific circulating tumor cells
Authors: Limaye Sewanti , Chowdhury Simon , Rohatgi Nitesh , Ranade Anantbhushan , Syed Nelofer , Riedemann Johann , Patil Darshana , Akolkar Dadasaheb , Datta Vineet , Patel Shoeb , Chougule Rohit , Shejwalkar Pradyumna , Bendale Kiran , Apurwa Sachin , Schuster Stefan , John Jinumary , Srinivasan Ajay , Datar Rajan 
Published: January 2023

AbstractBackgroundThe low specificity of serum PSA resulting in the inability to effectively differentiate prostate cancer from benign prostate conditions is a persistent clinical challenge. The low sensitivity of serum PSA results in false negatives and can miss high‐grade prostate cancers. We describe a non‐invasive test for detection of prostate cancer based on functional enrichment of prostate adenocarcinoma associated circulating tumor cells (PrAD‐CTCs) from blood samples followed by their identification by immunostaining for pan‐cytokeratins (PanCK), prostate specific membrane antigen (PSMA), alpha methyl‐acyl coenzyme‐A racemase (AMACR), epithelial cell adhesion molecule (EpCAM), and common leucocyte antigen (CD45).MethodsAnalytical validation studies were performed to establish the performance characteristics of the test using VCaP prostate cancer cells spiked into healthy donor blood (HDB). The clinical performance characteristics of the test were evaluated in a case–control study with 160 known prostate cancer cases and 800 healthy males, followed by a prospective clinical study of 210 suspected cases of prostate cancer.ResultsAnalytical validation established analyte stability as well as acceptable performance characteristics. The test showed 100% specificity and 100% sensitivity to differentiate prostate cancer cases from healthy individuals in the case control study and 91.2% sensitivity and 100% specificity to differentiate prostate cancers from benign prostate conditions in the prospective clinical study.ConclusionsThe test accurately detects PrAD‐CTCs with high sensitivity and specificity irrespective of stage, serum PSA or Gleason score, which translates into low risks of false negatives or overdiagnosis. The high accuracy of the test could offer advantages over PSA based prostate cancer detection.