bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initier la PrEP en médecine de ville et envisager la santé sexuelle des personnes en situation de migration
Authors: Ahouanto-Chaspoul Marie , Linard Françoise , Giannotti Agnès , Viomesnil Vanessa , Phammavanh Jacques , Vanlerberghe Franck , Segouin Christophe 
Published: December 2022

En juin 2020, 32 000 personnes avaient initié une prophylaxie préexposition au VIH (PrEP) en France. L’objectif de ce travail est de proposer la PrEP à la population des migrants en cabinets de ville en collaboration avec l’hôpital. Il se déroule à Paris dans le quartier de la Goutte-d’Or où plus d’un tiers des habitants est né à l’étranger [1]. La maison de santé pluridisciplinaire (MSP) et multisites Goutte-d’Or, composée de professionnels de santé libéraux a accueilli cette étude. Les obstacles à surmonter sont nombreux, notamment aborder la sexualité et présenter une méthode de prévention peu connue des personnes en situation de migration. De surcroît, la primoprescription d’antirétroviraux (ARV) à cette période devait être faite par un médecin hospitalier (jusqu’au 1 er juin 2021) [2]. L’hypothèse de travail est que les médecins traitants peuvent surmonter ces obstacles dans le cadre d’un protocole définissant les échanges sur la sexualité et l’organisation d’une consultation PrEP conjointe médecin traitant/médecin hospitalier dans les murs des cabinets de ville. L’étude s’est déroulée du 1 er mars 2018 au 31 octobre 2020, 180 questionnaires concernant l’opportunité de la PrEP ont été administrés par les médecins traitants (MT) et la sage-femme de la MSP. Au total, 43 personnes ont été identifiées comme pouvant bénéficier de la PrEP ; 24 PrEP ont été prescrites, 23 en continu et une à la demande. Un entretien semi-directif en santé sexuelle a été proposé aux 43 personnes pressenties pour une consultation PrEP. Les entretiens approfondis confirment que si la santé sexuelle n’est pas la première demande des consultants, il existe cependant de réels besoins non pris en compte le plus souvent.
Burnout syndrome chez les internes en médecine marocains
Authors: El Bouri Hicham , Kamal Benslimane Ibtissam , Nani Samira 
Published: December 2022

Introduction : Les internes en médecine sont soumis à un stress chronique dû aux longues heures de travail, de privation de sommeil et de temps de loisirs pouvant engendrer un burnout . L’objectif de cette étude était d’estimer la prévalence du burnout chez les internes en médecine du CHU de Casablanca et d’en étudier les facteurs de risque. Méthodes : Nous avons mené une étude transversale, au cours du mois de mars 2017, auprès des internes en médecine du CHU de Casablanca. L’exploration du burnout a été réalisée grâce au Maslash Burnout Inventory . Les données ont été recueillies grâce à un auto-questionnaire. La saisie et l’analyse des données ont été réalisées grâce au logiciel SPSS version 16.0. Résultats : La prévalence du burnout était de 90 %. Les variables qui y étaient statistiquement associées étaient le sexe féminin (p=0,024) et la somnolence diurne excessive (p=0,025) pour la composante « Épuisement Émotionnel », et le nombre d’heures de travail pour la composante « Accomplissement Personnel » (p=0,05). Conclusions : Cette enquête a révélé un taux inquiétant de burnout auprès des internes en médecine. Des actions préventives devraient être entreprises pour préserver la santé mentale de cette population à haut risque de burnout .
Repensando el capital social en la era digital y en sociedades diversas
Authors: Gil de Zúñiga Homero , Mateos Araceli , Inguanzo Isabel 
Published: December 2022

Este artículo introduce el volumen monográfico que lleva por título ‘Capital Social en Democracia: Una Perspectiva de la Influencia del Capital Social en Sociedades Diversas’. En primer lugar, este artículo captura brevemente y con una mirada temática amplia, las distintas acepciones y operacionalizaciones de Capital Social, y cómo se ha introducido el constructo a través de diferentes disciplinas. El artículo también explica el devenir del Capital Social dentro del contexto de internet y las redes sociales, así como desgrana nuevos actores y temas en torno a esta materia. Finalmente, se incluye una sección donde se integran los resúmenes de cada uno de los estudios que componen este monográfico.
The Effect of Vibrational Devices on Pain in Patients Undergoing Orthodontic Treatment
Authors: Chawla Shilpa , Rodrigues Lishoy , Deshmukh Shailesh , Vajarekar Gaury Anant 
Published: December 2022

Objective:
To critically evaluate the existing evidence with respect to the effect of vibrational devices on pain levels during orthodontic treatment.

Materials and Methods:
Unrestricted electronic search in PubMed/MEDLINE, Directory of open access journal, Cochrane Central as well as manual searches was conducted up to June 2020. Only randomized-controlled trials (RCTs) were included. Study selection, data extraction, and bias assessment were done by two independent reviewers. The Cochrane risk-of-bias tool was used, and the quality of evidence was graded using the grading of recommendations assessment, development, and evaluation approach. A fixed-effects meta-analysis of continuous data, with its 95% confidence intervals (CIs), was used.

Results:
Nine RCTs were included for qualitative synthesis and the overall quality was moderate and had an overall low risk of bias. Several shortcomings were observed because of the lack of blinding of the participants as well as the investigators. We conducted a meta-analysis for two studies which assessed the pain using (visual analog scale) which showed (standard mean difference 1.83, 95% CI, −7.18–10.84) with fixed effect model based on the heterogeneity value of I
2. Results also showed a statistically nonsignificant difference regarding the effect of vibrational devices on pain levels when compared with no vibratory stimulus and sham devices.

Conclusions:
There is weak evidence indicating the effect and use of vibrational devices in orthodontic treatment. The meta-analysis aided us to conclude that there is no significant difference in the pain outcome after the use of vibrational devices as compared to the control group and having no effect on pain levels in patients undergoing orthodontic treatment.
A Review of The Genesis of Innovation: Systemic Linkages between Knowledge and the Market, Edited by Blandine Laperche, Dimitri Uzunidis, Nick von Tunzelmann, Cheltenham UK, Edward Elgar, 2008, 285 pp.
Authors: Gârdu Dana 
Published: December 2022

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Though almost onecentury old, the Schumpeterian statement that innovation is the true driver of welfareenhancing economic development captures the essence of today's knowledge economy. In his acceptation innovation refers to new combinations conducive to new products, new production processes, new markets, new organizational forms, and the discovery of new resources. Currently the fierce global race challenges nationstates and transnational corporations (TNC) to engage in the management of innovation in order to secure competitive advantages, hence their recurrent initiatives in science and technology (S&T)/innovation policies, and regional development. In a bestcase scenario this endeavour produces innovative milieux underpinned by vibrant interactions among major players (companies, research organizations, local communities, regional and central governments, etc.), and integrates them into other networks spawning knowledge externalities.
siRNA Mediated Gene Silencing in the Pancreatic Cancer Capan-1 Cell Line
Authors: BUDAK YILDIRAN Azize 
Published: December 2022

Today, pancreatic cancer ranks second after the cardiovascular system among the causes of death. The pancreatic cancer which is an aggressive type progressing without giving too many symptoms. In addition, factors such as difficulty in early diagnosis, rapid metastasis and non-response to traditional treatments cause a low survival rate in this type of cancer. Therefore, many studies are carried out to develop alternative diagnosis and treatment methods. Focus is put on target-oriented studies to increase the survival rate and eliminate other negative effects. The gene therapy method is at the forefront of such studies. RNA interference (RNAi) molecules are crucial in this method. From among these molecules, small non-coding RNA (siRNA) are used in studies as a therapeutic agent by its delivery to the target gene by various mechanisms. Studies are carried out with different biological and chemical agents to deliver the molecules to the target cell efficiently.
This study aimed to silence the c-Myc gene using gold nanoparticle (AuNP)-siRNA in the Capan-1 cell line. We performed Real-Time PCR, Dual Staining and gel electrophoresis using gold nanoparticles (2X, 4X, 8X) and siRNA (25 nM) at concentrations determined in the Capan-1 cell line. The data obtained from the analysis suggested that the nanoparticle siRNA complex could be used effectively in silencing the target gene. Nevertheless, effective results could be obtained with more knowledge on this subject.
ANALISIS PENGARUH GOOD CORPORATE GOVERNANCE DAN INTELLECTUAL CAPITAL TERHADAP NILAI PERUSAHAAN IDXESGL30
Authors: Herdani Emir Fikri , Kurniawati Rossita 
Published: December 2022

<p>Penelitian ini bertujuan untuk mengetahui pengaruh <em>intellectual capital </em>melalui VAIC<sup>TM</sup> (VAHU, VACA dan STVA) dan <em>good corporate governance </em>melalui variabel Kepemilikan Manajerial, Kepemilikan Institusional, Komposisi Komisaris Independen dan Kualitas Audit terhadap Nilai Perusahaan. Penelitian ini adalah penelitian kuantitatif. Populasi penelitian adalah perusahaan yang terdaftar dalam indeks IDXESGL, dan sampel penelitian adalah sejumlah 30 perusahaan. Dalam penelitian ini data yang digunakan adalah data sekunder. Analisis yang digunakan dalam penelitian ini adalah analisis analisis deskriptif, uji koefisien determinasi (R2), Uji Regresi Linier Berganda, <em>goodness of fit</em>, uji signifikansi parameter individual (uji t) dengan menggunakan program SPSS versi 25. Hasil penelitian ini menunjukan bahwa : (1) variabel <em>intellectual capital </em>tidak berpengaruh signifikan terhadap nilai perusahaan; (2) variabel kepemilikan manajerial tidak berpengaruh signifikan terhadap nilai perusahaan; (3) variabel kepemilikan institusional tidak berpengaruh signifikan terhadap nilai perusahaan; (4) komposisi komisaris independen berpengaruh positif terhadap nilai perusahaan; dan (5) kualitas audit tidak berpengaruh signifikan terhadap nilai perusahaan.</p><p> </p>
Islamic Boarding School (Pondok Pesantren) , Independent And Community Empowerment
Authors: Purwoko Dwi 
Published: December 2022

Implementation of the learning system at Islamic Boarding Schools (Pondok Pesantren – commonly called in Indonesia) usually leaves an imprint in the memory of the students who in turn will make it perspective that can be applied in their everyday lives, both in their ways of thinking and when they make good deeds blessed by the God. In addition, the Islamic Boarding School that plays strategic roles and has long been rooted in the Indonesian society has its own force in arousing the spirit and passion of the students to advance towards more prosperous and independent life. The values learned in the school, in particular its values of self-reliance, have encouraged the santri to practice these values in the society. Coming from such background, this research aims to provide an overview of the boarding schools that teach independent life to the students who in turn, when they graduate, they may empower the community in which they live.Penerapan sistem pembelajaran di Pondok Pesantren biasanya meninggalkan jejak dalam ingatan para santri yang pada gilirannya akan menjadikannya cara pandang yang dapat diterapkan dalam kehidupan sehari-hari, baik dalam cara berpikirnya. dan ketika mereka melakukan perbuatan baik yang diberkati oleh Tuhan. Selain itu, Pondok Pesantren yang memiliki peran strategis dan telah lama mengakar dalam masyarakat Indonesia memiliki kekuatan tersendiri dalam membangkitkan semangat dan gairah santri untuk maju menuju kehidupan yang lebih sejahtera dan mandiri. Nilai-nilai yang dipelajari di sekolah, khususnya nilai-nilai kemandirian, telah mendorong santri untuk mengamalkan nilai-nilai tersebut di masyarakat. Berangkat dari latar belakang tersebut, penelitian ini bertujuan untuk memberikan gambaran tentang pesantren yang mengajarkan kehidupan mandiri kepada para santrinya yang pada gilirannya kelak ketika mereka lulus dapat memberdayakan masyarakat di mana mereka tinggal.
Cooperation Maxim Error Principles and Implications on Warintil Official Series “Ga Boleh Souzon”
Authors: Passandaran Yosi Maeleona , Zaimar Yulia Sofiani , Tiwiyanti Leni 
Published: December 2022

<p>This article would like to describe the error of maxims and also the meaning of implicatures in the sitcom of <em>Kontrakan Rempong </em>from Warintil Official on Youtube. There were five types of violations of the cooperative principle caused by the speech participants. The research method used in this research is descriptive qualitative. The data is taken from <em>Kontrakan Rempong</em>, titled “<em>Gak Usah Souzon”</em>. The collecting data are using the documentation method by listening and note-taking techniques from the <em>Kontrakan Rempong’ </em>characters' conversation. Meanwhile, the object of this research is the form and meaning of implicature in humour <em>Kontrakan Rempong.</em> The results of this research indicate the form of conversational implicatures that function as a supporter of humour in humorous discourse<em>, </em>they are:<em> </em><em> the Youtube </em><em>Kontrakan Rempong<em> </em></em><em>has a violation of the maxim of the cooperative principle. In the maxim of quality, there are two categories of violations<strong>;</strong> they are the words that are used solely to show her or his arrogance and to make the main character a fool. In other words</em><em>, </em><em>the error maxim is seemed as trying to evade responsibility</em><em>.</em> The function of violation of the Maximal Principle of cooperation has been categorized based on existing data<em> </em><em>like wisdom maxim, acceptance maxim, humility maxim, quality maxim</em><em>, </em>approbation maxim<em><strong> </strong></em><em>and quantity maxim.</em><em> </em>The maxims error is the error of quantity maxim, quality maxim, wisdom maxim approbation and humility maxim. In addition to supporting humour, the error causes many implications related to human nature and real life.</p><p><strong>Keywords: humour, error, maxim,</strong><strong> implicature</strong></p><p> </p>
Simile Expressions in ‘Everything at Once’ Song Lyrics by Lenka
Authors: Yuliasari Ria , Virtianti Rika 
Published: December 2022

<p>In this digital era 4.0, more and more people are realizing the importance of learning foreign languages, especially English. They learn through any source they can access digitally and one of the media used is through music and songs. But actually learning English through songs has its own challenges because song lyrics are often different from spoken language, one of which is the use of language style. This research aims at analyzing simile expressions found in the song lyrics of ‘Everything at Once’ by Lenka. The method used in this research is descriptive qualitative to analyze the types of simile expressions found in the song lyrics. The analysis of the types of simile expressions is carried out using theory of Zhang and Fromilhague. The result of analysis shows that ‘Everything at Once’ song has 38 simile expressions and they all belong to the type of closed and explicit simile.</p><p><strong> </strong></p><p><strong>Keywords: simile, song, lyrics.</strong></p>
Ependymoma: an epidemiological perspective from a low- and middle-income country
Authors: Muhammad Usman Khalid  , Mashal Murad Shah  , Mohammad Hamza Bajwa  , Karim Rizwan Nathani  , Altaf Ali Laghari   , Muhammad Faraz Raghib   , Saad bin Anis  , Naveed Zaman Akhunzada  , Sameen Siddiqi   , Syed Ather Enam  
Published: December 2022

Objective: To enumerate the burden of ependymoma in our region and identify the demographic, tumoural, surgical, clinical characteristics, and outcomes of patients diagnosed with ependymoma.
Methods: This retrospective cross-sectional study included patients admitted under neurosurgical service between January 1 and December 31, 2019. The inclusion criterion for the study was a histopathological diagnosis of the brain lesion. The experience of the ependymal brain tumours observed at the 32 participating sites in Pakistan is presented.
Results: A total of 2750 patients with brain tumours were seen in 2019 at our centres of whom 58(2.1%) had a histopathological diagnosis of ependymoma. The median age at diagnosis was nine (IQR= 4.5-24.5) years. The median time to surgery from date of radiological diagnosis was 38.5 (IQR= 4-93.8) days. The median KPS score at presentation was 70 (IQR= 60-80), and post-surgery was 90 (IQR= 70-100), showing an average increase of 20. Our population's overall mortality rate for ependymoma was 31.1%, with the 30-day mortality rate being 2.2% (lower than the 4.5% on average for all brain tumours in our cohort).
Conclusion: Ependymomas were predominantly found in the paediatric population in the presented cohort. While gender distribution and histopathological grading seemed to follow international trends, this study had a much higher mortality rate and a much lower gross total resection rate than centres in high-income countries.
Keywords: Ependymoma, Brain neoplasm, Retrospective study, Epidemiology, LMIC.
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A national overview of paediatric and adolescent and young adult surgical neuro-oncology in Pakistan
Authors: Faiza Urooj  , Mohammad Hamza Bajwa  , Muhammad Usman Khalid  , Mashal Murad Shah  , Ahsan Ali Khan  , Ummey Hani   , Altaf Ali Laghari   , Jaleed Ahmed Gilani  , Noyan Jawed  , Muhammad Faraz Raghib  , Saad bin Anis  , Naveed Zaman Akhunzada  , Sameen Siddiqi  , Syed Ather Enam  
Published: December 2022

Objective: To build a comprehensive brain tumour database that will allow us to analyse in detail the prevalence, demographics, and outcomes of the disease in paediatric, adolescent, and young adult age groups.
Method: A national cross-sectional study was conducted at 32 centres, and data regarding patient demographics and brain tumours were collected. This data was then stratified based on age groups, healthcare sectors, socioeconomic status, tumour types, and surgical outcomes.
Result: Most of the patients who were diagnosed with brain tumours belonged to a lower socioeconomic background and went to public sector hospitals. More males were diagnosed with and treated for brain tumours in the paediatric, adolescent, and young adult populations. The most common tumour in the paediatric population was medulloblastoma (23.7%) and the most common tumour in the adolescent (27.8%) and young adult population (34.7%) was glioma. Significant improvement in KPS scores were seen for: craniopharyngioma (p = 0.001), meningioma (p < 0.0005) and pituitary adenoma (p < 0.0005)
Conclusion: This study shows that in all three age groups, there was a greater prevalence in males. Most of the patients belonged to a lower-middle-income class background and most patients presented to public sector hospitals. Greater knowledge of these parameters unique to each age group is the key to understanding and alleviating the burden of disease. Cancer registries, specifically brain tumour registries that keep up-to-date records of these patients, are essential to identify and keep track of these unique parameters to advance medical research and treatment strategies, ultimately lowering the disease burden.
Keywords: Pediatric, Neuro-oncology, Adolescent and young adult, AYA, Medulloblastoma, Craniopharyngioma, Epidemiology.
MENINGKATKAN KREATIFITAS MAHASISWA MELALUI MODEL PEMBELAJARAN KOOPERATIF TIPE STUDENT TEAMS ACHIEVEMENT DIVISION
Authors: Fatmawati Suci 
Published: December 2022

Pembelajaran yang berkualitas bergantung pada metode pembelajaran yang digunakan oleh Dosen dalam mentransfer ilmu, oleh karena itu metode kooperatif menjadi salah satu alternatif pembelajaran yang diteliti dalam mengukur kreativitas mahasiswa. Tujuan Penelitian ini ialah untuk mengetahui perbedaan kreativitas mahasiswa yang menggunakan model pembelajaran kooperatife tipe Student Teams Achievement Division dengan pembelajaran biasa. Metode ini diterapkan pada mahasiswa Universitas Islam Makassar Tahun ajaran 2019/2020. Kelas VII A sebagai kelas yang tidak diberikan perlakuan menggunakan model pembelajaran kooperatif tipe STAD dan kelas VII B sebagai kelas yang diberi perlakuan model pembelajaran Student Teams Achievement Division STAD. Tahap awal pengumpulan data dilakukan melalui tes, observasi dan dokumentasi. Uji coba instrumen menggunakan uji realibilitas dan validitas. Data analisis yang digunakan adalah uji normalitas dan homogenitas untuk menguji hipotesis digunakan uji t. Hasil penelitian menunjukkan adanya perbedaan hasil yang signifikan antara yang menggunakan metode STAD dengan yang tidak menggunakan metode tersebut. Penelitian menyimpulkan bahwa kreativitas mahasiswa yang menggunakan metode STAD lebih baik dibanding yang tidak menggunakan tipe STAD.
PERBANDINGAN POSISI 1G, 2G DAN 3G TERHADAP KEKUATAN TARIK SAMBUNGAN LAS SMAW DENGAN MODEL KAMPUH V DAN KAMPUH X
Authors: M Saripuddin , Juma Djufri , Syamsuddin Junaedy , Muhajir Muhajir 
Published: December 2022

Proses penyambungan pelat dengan cara pengelasan pada saat ini sangat banyak digunakan, hal ini dikarenakan proses pengelasan akan sangat lebih cepat dan efisien. Penyebab terjadinya kerusakan pada pengelasan adalah penggunaan jenis kampuh las yang tidak sesuai dengan pembebanan ketika proses pengelasan. Penelitian ini bertujuan untuk mengetahui perbandingan dari kekuatan sambungan las dengan menggunakan kampuh V dan X dengan posisi pengelasan datar, vertikal dan horizontal. Penelitian menggunakan metode eksperimental yaitu menyambung dua pelat logam yang berbeda dengan menggunakan mesin las SMAW. Jenis sambungan yang digunakan adalah sambungan kampuh V dan kampuh X dengan ukuran panjang 15 cm, lebar 2 cm dan tebal 10 mm sesuai standar ASTM E8. Kemudian dilakukan pengujian meliputi pengujian tarik, spesimen uji tarik, dan menghitung regangan dan tegangan. Hasil penelitian ditunjukkan dengan arus las berpengaruh terhadap kekuatan tarik pengelasan SMAW. Adapun hasil dari penelitian yang dilakukan menunjukkan nilai kekuatan tarik yang variatif untuk kampuh v pada posisi pengelasan datar 40,297Mpa posisi vertical 40,824 Mpa dan posisi hotizontal 39,979 sedangkan untuk kampuh x nilainya pun bervariatif, pada posisi mendatar sebesar 41,666 Mpa untuk posisi vertical dan horizontal masing-masing 41,666 dan 41,788 Mpa. Kesimpulannya adalah Kekuatan tarik tertinggi dihasilkan oleh jenis kampuh X 2G dengan nilai rata-rata kekuatan tarik sebesar 417,14 MPa sedangkan kekuatan tarik terendah terdapat pada jenis kampuh V 2G dengan nilai rata-rata sebesar 39, 787 MPa.