bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying Continental Crust Thickness Using the Machine Learning Method
Authors: Guo Peng , Yang Ting 
Published: March 2023

AbstractCrustal thickness plays a key role in many geological processes. However, it remains challenging to quantify crustal thickness in the geological past. Here we propose an Extremely Randomized Trees algorithm‐based machine learning model to recover crustal thickness of old geological regions. The model is trained using major oxide and trace element compositions of 1,480 young intermediate to felsic rocks from global arcs and collisional orogens and geophysical measurements of crustal thickness. The model provides better estimations of crustal thickness than the commonly used methods based on Sr/Y and (La/Yb)N when applied to the testing data. The validity of this model is further demonstrated by its applications to the Kohistan–Ladakh, Gangdese and Talkeetna arcs, where paleocrustal thicknesses have been well constrained. We then use this model to construct the Mesozoic crustal thickness evolution of the Erguna Block in the southeast of the Mongol–Okhotsk suture belt. The closure time of the suture zone is still debated. Our results suggest that the crustal thickness of the Erguna Block increased from 43 ± 9 km at 210 Ma to 62 ± 7 km at 180 Ma, remained constant between 180 and 150 Ma, and then thinned to 36 ± 4 km at 120 Ma. These results suggest that the Mongol–Okhotsk Ocean closed in the Early–Middle Jurassic and the thickened crust was stretched during the Cretaceous. We show that the thick crust and compression‐extension transition seem to be favorable for the formation of porphyry copper deposits in the Erguna Block during the Late Jurassic.
Evolution of Stresses Over Conjugate Faults in Hjalli‐Ölfus, South Iceland
Authors: Parameswaran Revathy M. , Bjarnason Ingi Th. , Thorbjarnardóttir Bergthóra S. 
Published: March 2023

AbstractHjalli‐Ölfus is the westernmost segment of the east‐west transform South Iceland Seismic Zone (SISZ), which is the eastward extension of the ∼ENE‐trending transtensional Reykjanes Peninsula (RP). Historically, the area has shown an interactive behavior with the Hengill volcanic system to the north and the central SISZ to the east. We analyzed the state of stress and faulting mechanisms in Hjalli‐Ölfus between July 1991 and December 1999, in connection with the Hengill inflation episode (Feigl et al., 2000, https://doi.org/10.1029/2000JB900209) and the 13th November 1998 Mw 5.1 Hjalli‐Ölfus earthquake. We find that this region predominantly hosted oblique‐normal and left‐lateral strike‐slip events (4–10 km‐depth), with most nodal planes oriented along ∼ENE or ∼WSW directions (75° ± 15° or 255° ± 15°). We identify 5 stages of stress evolution from January 1991 to December 1999 over which Hjalli‐Ölfus experiences both spatial and temporal shifts in stress‐states. The Hengill inflation likely loaded both the fissure zone and western Ölfus, culminating in the Mw 5.4 (Hengill) and Mw 5.1 (Hjalli‐Ölfus) earthquakes. Following these events, the maximum compressive stress (SHmax) orientation near the location of the Mw 5.1 earthquake showed a ∼5°–7° counterclockwise swing, compared to SHmax before June 1998. The average SHmax (∼40° ± 1°) and minimum principal stress ( ∼ 130° ± 1°) are comparable to geological trends in the RP. We conclude that Hjalli‐Ölfus shows clockwise SHmax rotation upon loading, while a stress‐drop reverses the rotation. We also posit that the region, especially the western end, behaves like the RP during interseismic periods.
Preface: Special Issue on Ophiolites and Oceanic Lithosphere
Authors: Kelemen Peter B. , Matter Jürg M. , Teagle Damon A. H. , Coggon Jude A. , Godard Marguerite , Michibayashi Katsuyoshi , Takazawa Eiichi , Templeton Alexis S. , Williams Ken , Al Sulaimani Zaher 
Published: March 2023

AbstractWith this Preface, we provide background information, a scientific overview of topics, and an annotated bibliography of the 63 papers published in the Journal of Geophysical Research (JGR) Special Issue on “Ophiolites and Oceanic Lithosphere, with a Focus on the Samail Ophiolite,” collected online at https://agupubs.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)2169-9356.SAMAIL1. Topics covered in the Special Issue include formation and alteration of igneous ocean crust at submarine spreading centers, subduction zone mass transfer at the leading edge of the mantle wedge, the tectonic emplacement and evolution of ophiolites, processes of alteration and weathering of tectonically exhumed mantle peridotite, and the subsurface biosphere in the peridotite weathering environment. The bibliography, in the form of a supplementary Excel spreadsheet with links to each paper, is organized by topic, but can be sorted by first author, order of publication, specific Oman Drilling Project boreholes, and other factors.
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
Authors: Ji Shuaifei , Xiong Mingchen , Chen Huating , Liu Yiqiong , Zhou Laixian , Hong Yiyue , Wang Mengyang , Wang Chunming , Fu Xiaobing , Sun Xiaoyan 
Published: March 2023

AbstractThe ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells or organisms more youthful characteristics through various techniques, such as cellular reprogramming and epigenetic regulation. The great leaps in cellular rejuvenation prove that ageing is not a one-way street, and many rejuvenative interventions have emerged to delay and even reverse the ageing process. Defining the mechanism by which roadblocks and signaling inputs influence complex ageing programs is essential for understanding and developing rejuvenative strategies. Here, we discuss the intrinsic and extrinsic factors that counteract cell rejuvenation, and the targeted cells and core mechanisms involved in this process. Then, we critically summarize the latest advances in state-of-art strategies of cellular rejuvenation. Various rejuvenation methods also provide insights for treating specific ageing-related diseases, including cellular reprogramming, the removal of senescence cells (SCs) and suppression of senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune rejuvenation and heterochronic transplantation, etc. The potential applications of rejuvenation therapy also extend to cancer treatment. Finally, we analyze in detail the therapeutic opportunities and challenges of rejuvenation technology. Deciphering rejuvenation interventions will provide further insights into anti-ageing and ageing-related disease treatment in clinical settings.
Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington’s disease model mice
Authors: Pancani Tristano , Day Michelle , Tkatch Tatiana , Wokosin David L. , González-Rodríguez Patricia , Kondapalli Jyothisri , Xie Zhong , Chen Yu , Beaumont Vahri , Surmeier D. James 
Published: March 2023

AbstractHuntington’s disease (HD) is a progressive, neurodegenerative disease caused by a CAG triplet expansion in huntingtin. Although corticostriatal dysfunction has long been implicated in HD, the determinants and pathway specificity of this pathophysiology are not fully understood. Here, using a male zQ175+/− knock-in mouse model of HD we carry out optogenetic interrogation of intratelencephalic and pyramidal tract synapses with principal striatal spiny projection neurons (SPNs). These studies reveal that the connectivity of intratelencephalic, but not pyramidal tract, neurons with direct and indirect pathway SPNs increased in early symptomatic zQ175+/− HD mice. This enhancement was attributable to reduced pre-synaptic inhibitory control of intratelencephalic terminals by striatal cholinergic interneurons. Lowering mutant huntingtin selectively in striatal cholinergic interneurons with a virally-delivered zinc finger repressor protein normalized striatal acetylcholine release and intratelencephalic functional connectivity, revealing a node in the network underlying corticostriatal pathophysiology in a HD mouse model.
Two-photon fluorescence imaging and specifically biosensing of norepinephrine on a 100-ms timescale
Authors: Mao Leiwen , Han Yujie , Zhang Qi-Wei , Tian Yang 
Published: March 2023

AbstractNorepinephrine (NE) is a key neurotransmitter in the central nervous system of organisms; however, specifically tracking the transient NE dynamics with high spatiotemporal resolution in living systems remains a great challenge. Herein, we develop a small molecular fluorescent probe that can precisely anchor on neuronal cytomembranes and specifically respond to NE on a 100-ms timescale. A unique dual acceleration mechanism of molecular-folding and water-bridging is disclosed, which boosts the reaction kinetics by ˃105 and ˃103 times, respectively. Benefiting from its excellent spatiotemporal resolution, the probe is applied to monitor NE dynamics at the single-neuron level, thereby, successfully snapshotting the fast fluctuation of NE levels at neuronal cytomembranes within 2 s. Moreover, two-photon fluorescence imaging of acute brain tissue slices reveals a close correlation between downregulated NE levels and Alzheimer’s disease pathology as well as antioxidant therapy.
Unraveling oxygen vacancy site mechanism of Rh-doped RuO2 catalyst for long-lasting acidic water oxidation
Authors: Wang Yi , Yang Rong , Ding Yajun , Zhang Bo , Li Hao , Bai Bing , Li Mingrun , Cui Yi , Xiao Jianping , Wu Zhong-Shuai 
Published: March 2023

AbstractExploring durable electrocatalysts with high activity for oxygen evolution reaction (OER) in acidic media is of paramount importance for H2 production via polymer electrolyte membrane electrolyzers, yet it remains urgently challenging. Herein, we report a synergistic strategy of Rh doping and surface oxygen vacancies to precisely regulate unconventional OER reaction path via the Ru–O–Rh active sites of Rh-RuO2, simultaneously boosting intrinsic activity and stability. The stabilized low-valent catalyst exhibits a remarkable performance, with an overpotential of 161 mV at 10 mA cm−2 and activity retention of 99.2% exceeding 700 h at 50 mA cm−2. Quasi in situ/operando characterizations demonstrate the recurrence of reversible oxygen species under working potentials for enhanced activity and durability. It is theoretically revealed that Rh-RuO2 passes through a more optimal reaction path of lattice oxygen mediated mechanism-oxygen vacancy site mechanism induced by the synergistic interaction of defects and Ru–O–Rh active sites with the rate-determining step of *O formation, breaking the barrier limitation (*OOH) of the traditional adsorption evolution mechanism.
Information about historical emissions drives the division of climate change mitigation costs
Authors: Del Ponte Alessandro , Masiliūnas Aidas , Lim Noah 
Published: March 2023

AbstractDespite worsening climate change, the international community still disagrees on how to divide the costs of mitigation between developing countries and developed countries, which emitted the bulk of historical carbon emissions. We study this issue using an economic experiment. Specifically, we test how information about historical emissions influences how much participants pay for climate change mitigation. In a four-player game, participants are assigned to lead two fictional countries as members of either the first or the second generation. The first generation produces wealth at the expense of greater carbon emissions. The second generation inherits their predecessor’s wealth and negotiates how to split the climate change mitigation costs. Here we show that when the second generation knows that the previous generation created the current wealth and mitigation costs, participants whose predecessor generated more carbon emissions offered to pay more, whereas the successors of low-carbon emitters offered to pay less.
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Authors: Foley Matthew H. , Walker Morgan E. , Stewart Allison K. , O’Flaherty Sarah , Gentry Emily C. , Patel Shakshi , Beaty Violet V. , Allen Garrison , Pan Meichen , Simpson Joshua B. , Perkins Caroline , Vanhoy Molly E. , Dougherty Michael K. , McGill Sarah K. , Gulati Ajay S. , Dorrestein Pieter C. , Baker Erin S. , Redinbo Matthew R. , Barrangou Rodolphe , Theriot Casey M. 
Published: March 2023

AbstractBile acids (BAs) mediate the crosstalk between human and microbial cells and influence diseases including Clostridioides difficile infection (CDI). While bile salt hydrolases (BSHs) shape the BA pool by deconjugating conjugated BAs, the basis for their substrate selectivity and impact on C. difficile remain elusive. Here we survey the diversity of BSHs in the gut commensals Lactobacillaceae, which are commonly used as probiotics, and other members of the human gut microbiome. We structurally pinpoint a loop that predicts BSH preferences for either glycine or taurine substrates. BSHs with varying specificities were shown to restrict C. difficile spore germination and growth in vitro and colonization in pre-clinical in vivo models of CDI. Furthermore, BSHs reshape the pool of microbial conjugated bile acids (MCBAs) in the murine gut, and these MCBAs can further restrict C. difficile virulence in vitro. The recognition of conjugated BAs by BSHs defines the resulting BA pool, including the expansive MCBAs. This work provides insights into the structural basis of BSH mechanisms that shape the BA landscape and promote colonization resistance against C. difficile.
A global daily soil moisture dataset derived from Chinese FengYun Microwave Radiation Imager (MWRI)(2010–2019)
Authors: Yao Panpan , Lu Hui , Zhao Tianjie , Wu Shengli , Peng Zhiqing , Cosh Michael H. , Jia Li , Yang Kun , Zhang Peng , Shi Jiancheng 
Published: March 2023

AbstractSurface soil moisture (SSM) is an important variable in drought monitoring, floods predicting, weather forecasting, etc. and plays a critical role in water and heat exchanges between land and atmosphere. SSM products from L-band observations, such as the Soil Moisture Active Passive (SMAP) Mission, have proven to be optimal global estimations. Although X-band has a lower sensitivity to soil moisture than that of L-band, Chinese FengYun-3 series satellites (FY-3A/B/C/D) have provided sustainable and daily multiple SSM products from X-band since 2008. This research developed a new global SSM product (NNsm-FY) from FY-3B MWRI from 2010 to 2019, transferred high accuracy of SMAP L-band to FY-3B X-band. The NNsm-FY shows good agreement with in-situ observations and SMAP product and has a higher accuracy than that of official FY-3B product. With this new dataset, Chinese FY-3 satellites may play a larger role and provide opportunities of sustainable and longer-term soil moisture data record for hydrological study.
SARS-CoV-2 receptor-binding domain deep mutational AlphaFold2 structures
Authors: Kilim Oz , Mentes Anikó , Pál Balázs , Csabai István , Gellért Ákos 
Published: March 2023

AbstractLeveraging recent advances in computational modeling of proteins with AlphaFold2 (AF2) we provide a complete curated data set of all single mutations from each of the 7 main SARS-CoV-2 lineages spike protein receptor binding domain (RBD) resulting in 3819X7 = 26733 PDB structures. We visualize the generated structures and show that AF2 pLDDT values are correlated with state-of-the-art disorder approximations, implying some internal protein dynamics are also captured by the model. Joint increasing mutational coverage of both structural and phenotype data coupled with advances in machine learning can be leveraged to accelerate virology research, specifically future variant prediction. We hope this data release can offer assistance into further understanding of the local and global mutational landscape of SARS-CoV-2 as well as provide insight into the biological understanding that 3D structure acts as a bridge between protein genotype and phenotype.
LocalView, a database of public meetings for the study of local politics and policy-making in the United States
Authors: Barari Soubhik , Simko Tyler 
Published: March 2023

AbstractDespite the fundamental importance of American local governments for service provision in areas like education and public health, local policy-making remains difficult and expensive to study at scale due to a lack of centralized data. This article introduces LocalView, the largest existing dataset of real-time local government public meetings–the central policy-making process in local government. In sum, the dataset currently covers 139,616 videos and their corresponding textual and audio transcripts of local government meetings publicly uploaded to YouTube–the world’s largest public video-sharing website–from 1,012 places and 2,861 distinct governments across the United States between 2006–2022. The data are processed, downloaded, cleaned, and publicly disseminated (at localview.net) for analysis across places and over time. We validate this dataset using a variety of methods and demonstrate how it can be used to map local governments’ attention to policy areas of interest. Finally, we discuss how LocalView may be used by journalists, academics, and other users for understanding how local communities deliberate crucial policy questions on topics including climate change, public health, and immigration.
Detection of Escherichia coli O157:H7 in imported meat products from Saudi Arabian ports in 2017
Authors: Alhadlaq Meshari Ahmed , Mujallad Mohammed I. , Alajel Sulaiman M. I. 
Published: March 2023

AbstractEscherichia coli O157:H7 is a foodborne pathogen, which causes various health conditions in humans, including fatigue, nausea, bloody diarrhoea and in some cases, even death. In 2017, 15.71% of the total imported food products in Saudi Arabia (SA) were meat-based. India and Brazil are two of the top five countries from where SA imports meat. According to the Saudi Food and Drug Authority, in 2017, at least 562, 280, and 50 samples of imported beef, chicken and sheep meat, respectively, were tested for the presence of E. coli O157:H7. Amongst these, E. coli O157:H7 was detected in respectively 6.80% and 2.20% of the tested beef meat samples imported from India and Brazil as well as in respectively 6.96% and 3.57% of the tested chicken samples imported from Brazil and Ukraine. Moreover, the pathogen was detected in 2.13% of the tested sheep meat samples imported from India. The present report provides evidence that imported meat can serve as the carrier of E. coli O157:H7, which may lead to epidemics within the Kingdom of Saudi Arabia.
Biomolecular and quantum algorithms for the dominating set problem in arbitrary networks
Authors: Wong Renata , Chang Weng-Long , Chung Wen-Yu , Vasilakos Athanasios V. 
Published: March 2023

AbstractA dominating set of a graph $$G = (V, E)$$

G
=
(
V
,
E
)

is a subset U of its vertices V, such that any vertex of G is either in U, or has a neighbor in U. The dominating-set problem is to find a minimum dominating set in G. Dominating sets are of critical importance for various types of networks/graphs, and find therefore potential applications in many fields. Particularly, in the area of communication, dominating sets are prominently used in the efficient organization of large-scale wireless ad hoc and sensor networks. However, the dominating set problem is also a hard optimization problem and thus currently is not efficiently solvable on classical computers. Here, we propose a biomolecular and a quantum algorithm for this problem, where the quantum algorithm provides a quadratic speedup over any classical algorithm. We show that the dominating set problem can be solved in $$O(2^{n/2})$$

O
(

2

n
/
2

)

queries by our proposed quantum algorithm, where n is the number of vertices in G. We also demonstrate that our quantum algorithm is the best known procedure to date for this problem. We confirm the correctness of our algorithm by executing it on IBM Quantum’s qasm simulator and the Brooklyn superconducting quantum device. And lastly, we show that molecular solutions obtained from solving the dominating set problem are represented in terms of a unit vector in a finite-dimensional Hilbert space.
Presence of non-symbiotic yeasts in a symbiont-transferring organ of a stag beetle that lacks yeast symbionts found in other stag beetles
Authors: Yamamoto Daichi , Toki Wataru 
Published: March 2023

AbstractDispersal from wood to wood is essential for wood-inhabiting fungi and wood-inhabiting insects play an important role in the dispersal success of such fungi. However, it is poorly understood whether wood-inhabiting insects which change the habitats from wood to non-wood environments can contribute to the fungal dispersal. Larvae of most stag beetles (Coleoptera: Lucanidae) are wood feeders, while adults are sap feeders. Female adults of lulcanids possess specialized organs (mycetangia) for transportation of fungal symbionts and harbor specific yeasts (e.g.,Scheffersomycesspp.) within. Here, we report that the lucanidAegus subnitidusharbors non-specific yeasts facultatively in mycetangia. We conducted yeast isolation from mycetangia and hindguts of female adults, in a larval gallery in wood-associated materials, and in female-visiting fermented tree sap using culture-dependent methods. Less than half of the females carried a total of 20 yeast species with small amounts using mycetangia and a female harbored up to five species, suggesting the absence of an intimate association with specific yeasts that are found in other lucanids. Yeast species compositions markedly differed between the larval gallery and sap. Most yeasts from the larval galley exhibited xylose-assimilation abilities, while few yeasts from sap did. Mycetangial yeasts comprised a combination from both sources. In hindguts, most yeasts were found in sap (> 70%) with no yeasts in the larval gallery. Sap-associated yeasts in each female mycetangium were also obtained from the female-visiting sap patch, while mycetangial, larval gallery-associated yeasts were absent from the patch, suggesting the survival success of larval gallery-associated yeasts in mycetangia through sap patches. Therefore, wood-inhabiting insects that possess mycetangia can potentially act as vectors of non-symbiotic wood-inhabiting yeasts dispersing from wood to wood via other environments.