bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of food certificate adoption on e-commerce income among small online agri-food sellers
Authors: Permani Risti , Sahara Sahara , Satria Dias , Suprehatin Suprehatin , Nuryartono Nunung 
Published: September 2023

PurposeThis paper aims to assess the determinants of food certificate adoption and analyse the impacts of food certificates on e-commerce income among small online agri-food sellers in Indonesia.Design/methodology/approachThe authors used data from an online survey of 228 small-online agri-food sellers in East Java, Indonesia. This study aims to focus on two food certificates: a mandatory Halal (Islamic dietary law) certificate and the P-IRT certificate, a food safety certificate for home-based businesses. A maximum simulated likelihood (MSL) estimator was employed to account for selection bias and endogeneity.FindingsThe study highlights the continued importance of certification in agri-food markets, including e-commerce and the need to consider the degree of substitutability and resource allocation between multiple food certificates. It finds that online agri-food sellers adopting the Halal certificate earn two to three times higher compared to non-adopters. Conversely, the gross income per month from e-commerce sales is 78% lower among those adopting the P-IRT certificate. Moreover, access to regulatory information sources motivates the likelihood of adopting food certificates. In contrast, the business size, marketing channels, contractual relationship and management capabilities are insignificant factors for the adoption of any of the Halal and P-IRT certificate combinations.Research limitations/implicationsResults from this research might be specific to the context of the focus study area, thereby reducing their generalisability. In addition to gathering representative samples, future research should also capture more complex dimensions of food certificates. These include the cost of acquiring food certificates, online sellers' perceptions of food certificate adoption, and emerging topics such as group certification and the use of technology.Originality/valueTo the authors' knowledge, this research is one of the first studies investigating the adoption of food certificates within the e-commerce setting. This study also contributes to the small number of studies looking at multiple certificate adoption and food certificate issues from the retailers' perspectives
Matching intra-functional integration with inter-firm IT linkage to facilitate flexibility for customers
Authors: Wang Shu , Liu Jing , Park Kihyun , Kang Mingu , Dai Fei 
Published: September 2023

Purpose
This study aims to suggest a moderated mediation model addressing how internal integration interacts with information technology (IT) link with external customers to meet customer needs more efficiently and effectively.

Design/methodology/approach
This study tests the proposed hypotheses by using 268 data collected from manufacturing firms worldwide.

Findings
The results of this study reveal that internal integration plays a very important role in promoting customer satisfaction directly and indirectly by enhancing the ability to meet customers’ flexibility needs. In addition, the results show that IT link with customers strengthens this indirect influencing relationship.

Originality/value
By combining IT connectedness with external customers with internal capability, this study provides valuable insights into how manufacturing firms apply internal integration more effectively to enhance customer satisfaction.
The relationship between economic complexity and green economy with earnings management
Authors: Ahmadi Zainab , Salehi Mahdi , Rahmani Mahmoud 
Published: September 2023

Purpose
This study aims to analyze the relationship between economic complexity (EC) and the green economy (GE) with the real and accrual earnings management (REM and AEM) of the listed companies on the Iranian stock exchange. The authors study whether EC and the GE can affect REM and AEM.

Design/methodology/approach
The authors used a multiple regression model based on the panel data and a fixed effect model to test hypotheses. The sample includes 1,351 companies listed on the Tehran Stock Exchange from 2014 to 2021.

Findings
The results show a positive and significant relationship between EC and the GE with REM and AEM.

Originality/value
Considering the importance of a GE and since this research is the first to address the mentioned topic in emerging markets, it provides helpful insights for financial statement users, analysts and legal entities. Our study fills the literature gap and promotes knowledge regarding its relevant literature. Examining this relationship portrays the latest research perspectives in this field. The information from this study can assist in environmental management decision-making and relevant policymaking, promoting the movement toward sustainable development.
Determinants of litigation risk in the Jordanian financial sector: the role of firm-specific indicators
Authors: Taha Rana , Taha Noor , Ananzeh Husam 
Published: September 2023

Purpose
This study aims to examine the impact of firm indicators on litigation risk in the Jordanian financial sector from 2017 to 2021, where the relationship between firm indicators and litigation risk in the Jordanian financial sector is a crucial area of research that can help financial institutions understand the factors that increase their probability of litigation risk.

Design/methodology/approach
The sample for this study comprised 92 publicly traded financial firms listed on the Amman Stock Exchange. The study used a quantitative research approach to analyse the relationship between four firm indicators (profitability, firm size, leverage and age) and their impact on litigation risk in the Jordanian financial sector from 2017 to 2021.

Findings
Our findings reveal that firm size has a significant positive impact on litigation risk, whereas profitability was found to have no significant impact on litigation risk. Moreover, the authors found that financial leverage substantially positively impacts litigation risk levels. However, the firm age was found to have no significant impact on litigation risk.

Originality/value
The results provide valuable insights into factors contributing to litigation risk in the Jordanian financial sector and the findings can inform strategic decisions for financial firms as they seek to manage litigation risk and improve financial performance. The study contributes to the existing literature on litigation risk by examining the impact of multiple firm indicators on litigation risk in the context of the Jordanian financial sector.
An empirical study on the leadership traits that enable successful six sigma implementation
Authors: Bagherian Anthony , Gershon Mark , Kumar Sunil 
Published: September 2023

PurposeSome Six Sigma (SS) efforts have not been entirely successful. This research paper aims to investigate the leadership style and the elements of it that positively influence the attainment of Six Sigma programs within the automobile industry.Design/methodology/approachThe study used a Likert-scale questionnaire and a simple random sampling method. 2,325 potential participants were approached, resulting in 573 responses, primarily from Germany, the United Kingdom and Sweden. 260 completed questionnaires were included in the analysis, utilizing an exploratory and mixed-methods research design to examine the impact of leadership style on Six Sigma success. Statistical methods such as SEM, EFA and CFA were used for data analysis.FindingsThe study utilized numerous SEM methods, including Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) and identified three key elements of leadership traits: (1) leadership support for long-term improvement strategies; (2) leadership commit to the supplier's organization to maintain quality and supply defect-free products.Research limitations/implicationsDue to limited participants, the outcome of the research could lead to inadequacies in data interpretation regarding the contextual predispostions, and the research could develop weaknesses in the form of cross-sectional instead of longitudinal data and design.Practical implicationsThe practical implications of this study suggest that institutions, practitioners and researchers can incorporate these two identified factors into leadership traits to promote the sustainable implementation of Six Sigma (SS) initiatives.Originality/valueThis study makes an original contribution to the assessment of leadership style and its elements in the European automobile industry, utilizing a mixed-methods research design along with descriptive statistics to provide valuable insights.
Ownership concentration and R&D investment: the moderating role of stock options
Authors: Qian Furong , Yuan Xiaoyong 
Published: September 2023

PurposeThis study aims to elaborate on how firms manage research and development (R&D) activities by examining the relationship between ownership concentration and corporate R&D investment, as well as the moderating role of stock options in this relationship.Design/methodology/approachThe study sample comprised 354 Chinese listed firms from 2011 to 2019, and the Tobit model and the system GMM test are used to check robustness.FindingsThe results reveal that ownership concentration and R&D investment have an inverted U-shaped relationship. In the presence of stock options, this inverted U-shaped relationship is significantly weaker.Originality/valueThe results have important managerial implications for firms that aim to grant stock options and improve the impact of ownership concentration on R&D investment strategies.
Remaking critical care: Place, body work and the materialities of care in the COVID intensive care unit
Authors: Montgomery Catherine M. , Docherty Annemarie B. , Humphreys Sally , McCulloch Corrienne , Pattison Natalie , Sturdy Steve 
Published: September 2023

AbstractIn this article, we take forward sociological ways of knowing care‐in‐practice, in particular work in critical care. To do so, we analyse the experiences of staff working in critical care during the first wave of the COVID‐19 pandemic in the UK. This moment of exception throws into sharp relief the ways in which work and place were reconfigured during conditions of pandemic surge, and shows how critical care depends at all times on the co‐constitution of place, practices and relations. Our analysis draws on sociological and anthropological work on the material culture of health care and its sensory instantiations. Pursuing this through a study of the experiences of 40 staff across four intensive care units (ICUs) in 2020, we provide an empirical and theoretical elaboration of how place, body work and care are mutually co‐constitutive. We argue that the ICU does not exist independently of the constant embodied work of care and place‐making which iteratively constitute critical care as a total system of relations.
Resolving phylogenetic relationships and taxonomic revision in the Pseudogastromyzon (Cypriniformes, Gastromyzonidae) genus: molecular and morphological evidence for a new genus, Labigastromyzon
Authors: CHEN Jingchen , CHEN Yiyu , TANG Wenqiao , LEI Haotian , YANG Jinquan , SONG Xiaojing 
Published: September 2023

AbstractThe Pseudogastromyzon genus, consisting of species predominantly distributed throughout southeastern China, has garnered increasing market attention in recent years due to its ornamental appeal. However, the overlapping diagnostic attributes render the commonly accepted criteria for interspecific identification unreliable, leaving the phylogenetic relationships among Pseudogastromyzon species unexplored. In the present study, we undertake molecular phylogenetic and morphological examinations of the Pseudogastromyzon genus. Our phylogenetic analysis of mitochondrial genes distinctly segregated Pseudogastromyzon species into two clades: the Pseudogastromyzon clade and the Labigastromyzon clade. A subsequent morphological assessment revealed that the primary dermal ridge (specifically, the second ridge) within the labial adhesive apparatus serves as an effective and precise interspecific diagnostic characteristic. Moreover, the distributional ranges of Pseudogastromyzon and Labigastromyzon are markedly distinct, exhibiting only a narrow area of overlap. Considering the morphological heterogeneity of the labial adhesive apparatus and the substantial division within the molecular phylogeny, we advocate for the elevation of the Labigastromyzon subgenus to the status of a separate genus. Consequently, we have ascertained the validity of the Pseudogastromyzon and Labigastromyzon species, yielding a total of six valid species. To facilitate future research, we present comprehensive descriptions of the redefined species and introduce novel identification keys.
SPdel: A pipeline to compare and visualize species delimitation methods for single‐locus datasets
Authors: Ramirez Jorge L. , Valdivia Paola , Rosas‐Puchuri Ulises , Valdivia Nereida L. 
Published: September 2023

AbstractAn accurate species delimitation is critical for biological studies. In this context, the use of molecular techniques along with species delimitation methods would help to a rapid and accurate biodiversity assessment. The species delimitation methods cluster data sets of orthologous sequences in molecular operational taxonomic units (MOTU). In particular, the methods based on a single gene are easily integrated with the widely used DNA barcoding approach. We developed SPdel a user‐friendly pipeline to integrate different single‐gene species delimitation methods. SPdel is designed to calculate and compare MOTUs obtained by different species delimitation approaches. SPdel also outputs diverse ready‐to‐publish quality figures, that facilitate the interpretation of results. SPdel aims to help researchers use species delimitation methods that would improve biodiversity studies.
Monitoring environmental microbiomes: Alignment of microbiology and computational biology competencies within a culturally integrated curriculum and research framework
Authors: Lee J. S. , Lowell J. L. , Whitewater K. , Roane T. M. , Miller C. S. , Chan A. P. , Sylvester A. W. , Jackson D. , Hunter L. E. 
Published: September 2023

AbstractWe have developed a flexible undergraduate curriculum that leverages the place‐based research of environmental microbiomes to increase the number of Indigenous researchers in microbiology, data science and scientific computing. Monitoring Environmental Microbiomes (MEM) provides a curriculum and research framework designed to integrate an Indigenous approach when conducting authentic scientific research and to build interest and confidence at the undergraduate level. MEM has been successfully implemented as a short summer workshop to introduce computing practices in microbiome analysis. Based on self‐assessed student knowledge of topics and skills, increased scientific confidence and interest in genomics careers were observed. We propose MEM be incorporated in a scalable course‐based research experience for undergraduate institutions, including tribal colleges and universities, community colleges and other minority serving institutions. This coupled curricular and research framework explicitly considers cultural perspectives, access and equity to train a diverse future workforce that is more informed to engage in microbiome research and to translate microbiome science to benefit community and environmental health.
Nivolumab as maintenance therapy following platinum‐based chemotherapy in EGFR‐mutant lung cancer patients after tyrosine kinase inhibitor failure: A single‐arm, open‐label, phase 2 trial
Authors: Kim Jiwon , Choi Chang‐Min , Ji Wonjun , Lee Jae Cheol 
Published: September 2023

AbstractBackgroundAs the outcome of immunotherapy can be improved when concurrently or sequentially combined with cytotoxic chemotherapy or radiotherapy, we investigated the efficacy of immunotherapy maintenance following platinum‐based chemotherapy in epidermal growth factor receptor (EGFR)‐mutant non‐small cell lung cancer (NSCLC) after EGFR‐tyrosine kinase inhibitor (EGFR‐TKI) failure.MethodsIn this prospective, open‐label, single arm phase 2 trial, we enrolled patients aged 18 years or older with EGFR‐mutant NSCLC, which progressed after first‐ or second‐line EGFR‐TKI. Patients received platinum‐based chemotherapy followed by nivolumab maintenance therapy. They were intravenously administered 240 mg of nivolumab every 2 weeks for 3 months followed by 480 mg every 4 weeks until disease progression or unacceptable toxic effects occurred. The primary endpoint was progression‐free survival (PFS). Secondary outcomes were overall survival (OS) and incidence of grade 3–4 treatment‐related adverse events (AEs).ResultsWe enrolled 26 patients between May 2020 and July 2021. The median PFS was 1.7 months (95% CI: 0.401–2.999 months). The median OS was 21.4 months (95% CI: 18.790–24.010 months) with 6‐ and 12‐month OS rates of 96.2% and 76.9%, respectively. The objective response rate was 7.7% (2/26) and disease control rate, 11.5% (3/26). The tumor mutational burden by next‐generation sequencing in blood was not related to the treatment outcomes. Grade 3–4 treatment‐related AEs occurred in four (15.4%) patients; the most frequent AE was increased alanine aminotransferase (7.7%).ConclusionNivolumab maintenance following platinum‐based chemotherapy did not show clinical benefits after EGFR‐TKI failure in patients with EGFR‐mutant NSCLC.
Intrapartum fetal heart rate monitoring: Rationalise, refine or replace?
Authors: Crouch Catherine , Seeho Sean , Morris Jonathan 
Published: September 2023

AbstractMonitoring the fetal heartbeat underpins assessment of fetal wellbeing in labour. Although commonly employed in clinical practice, shortcomings remain. A recent review of clinical practice guidelines highlights the variation in definitions of the fetal heart rate that will lead to differences in interpretation. Will intrapartum care be improved by greater consensus around clinical practice guidelines through rationalisation or refinement of guidelines, or will the future see this technique replaced by more accurate forms of fetal monitoring?
Letter: Safety after cessation of nucleos(t)ide analogue therapy in patients with chronic hepatitis B infection—Authors' reply
Authors: Hsu Yao‐Chun , Nguyen Mindie H. , Wu Chun‐Ying 
Published: September 2023

LINKED CONTENTThis article is linked to Hsu et al papers. To view these articles, visit https://doi.org/10.1111/apt.17614 and https://doi.org/10.1111/apt.17657
Low and very low lithium levels: Thyroid effects are small but still require monitoring
Authors: Phelps James , Coskey Olivia Pipitone 
Published: September 2023

AbstractAimLow doses of lithium, as might be used for mood or dementia prevention, do not carry the same renal, toxicity, and tolerability problems of doses used for prophylaxis or treatment of mania. However, thyroid effects of low doses have not been investigated. Our goal in this study was to assess the changes in thyroid‐stimulating hormone (TSH) associated with a broad range of lithium levels, including those well below the therapeutic range for bipolar disorders.MethodsThis study was conducted in a small healthcare system with 19 associated primary care clinics served by a Collaborative Care program of psychiatric consultation. In this retrospective review of electronic records, we searched for patients who had received a lithium prescription and both pre‐ and post‐lithium thyroid‐stimulating hormone (TSH) levels.ResultsPatients with low lithium levels (<0.5 mEq/L, N = 197) had a mean thyroid‐stimulating hormone (TSH) increase of 0.52 mIU/L. Patients with maintenance lithium levels (0.5–0.8 mEq/L; N = 123) had a mean TSH increase of 1.01 mIU/L; and patients with antimanic lithium levels (>0.8 mEq/L; N = 79) had a mean TSH increase of 2.16 mIU/L. The probability of TSH exceeding the upper limit of normal in our laboratory (>4.2 mIU/L) was positively associated with pre‐lithium TSH.ConclusionThese results suggest that the risk of lithium‐induced hypothyroidism is dose‐related, and relatively small with very low doses, but thyroid monitoring, including a pre‐lithium TSH, is still warranted.
Trends in postpartum hemorrhage and manual removal of the placenta and the association with childbirth interventions: A Dutch nationwide cohort study
Authors: Seijmonsbergen‐Schermers Anna E. , Rooswinkel Ellen T. C. , Peters Lilian L. , Verhoeven Corine J. , Jans Suze , Bloemenkamp Kitty , de Jonge Ank 
Published: September 2023

AbstractBackgroundBecause the cause of increasing rates of postpartum hemorrhage (PPH) and manual placental removal (MROP) is still unknown, we described trends in PPH, MROP, and childbirth interventions and examined factors associated with changes in rates of PPH and MROP.MethodsThis nationwide cohort study used national perinatal registry data from 2000 to 2014 (n = 2,332,005). We included births of women who gave birth to a term singleton child in obstetrician‐led care or midwife‐led care. Multivariable logistic regression analyses were used to examine associations between characteristics and interventions, and PPH ≥ 1000 mL and MROP.ResultsPPH rates increased from 4.3% to 6.6% in obstetrician‐led care and from 2.5% to 4.8% in midwife‐led care. MROP rates increased from 2.4% to 3.4% and from 1.0% to 1.4%, respectively. A rising trend was found for rates of induction and augmentation of labor, pain medication, and cesarean section, while rates of episiotomy and assisted vaginal birth declined. Adjustments for characteristics and childbirth interventions did not result in large changes in the trends of PPH and MROP. After adjustments for childbirth interventions, in obstetrician‐led care, the odds ratio (OR) of PPH in 2014 compared with the reference year 2000 changed from 1.66 (95% CI 1.57–1.76) to 1.64 (1.55–1.73) among nulliparous women and from 1.56 (1.47–1.66) to 1.52 (1.44–1.62) among multiparous women. For MROP, the ORs changed from 1.51 (1.38–1.64) to 1.36 (1.25–1.49) and from 1.56 (1.42–1.71) to 1.45 (1.33–1.59), respectively.ConclusionsRising PPH trends were not associated with changes in population characteristics and rising childbirth intervention rates. The rising MROP was to some extent associated with rising intervention rates.
ZNF500 abolishes breast cancer proliferation and sensitizes chemotherapy by stabilizing P53 via competing with MDM2
Authors: Ma Xiaowen , Fan Mingwei , Yang Kaibo , Wang Yuanyuan , Hu Ran , Guan Mengyao , Hou Yuekang , Ying Jiao , Deng Ning , Li Qingchang , Jiang Guiyang , Zhang Yong , Zhang Xiupeng 
Published: September 2023

AbstractZinc finger protein 500 (ZNF500) has an unknown expression pattern and biological function in human tissues. Our study revealed that the ZNF500 mRNA and protein levels were higher in breast cancer tissues than those in their normal counterparts. However, ZNF500 expression was negatively correlated with advanced TNM stage (p = 0.018), positive lymph node metastasis (p = 0.014), and a poor prognosis (p < 0.001). ZNF500 overexpression abolished in vivo and in vitro breast cancer cell proliferation by activating the p53‐p21‐E2F4 signaling axis and directly interacting with p53 via its C2H2 domain. This may prevent ubiquitination of p53 in a manner that is competitive to MDM2, thus stabilizing p53. When ZNF500‐∆C2H2 was overexpressed, the suppressed proliferation of breast cancer cells was neutralized in vitro and in vivo. In human breast cancer tissues, ZNF500 expression was positively correlated with p53 (p = 0.022) and E2F4 (p = 0.004) expression. ZNF500 expression was significantly lower in patients with Miller/Payne Grade 1–2 than in those with Miller/Payne Grade 3–5 (p = 0.012). ZNF500 suppresses breast cancer cell proliferation and sensitizes cells to chemotherapy.