bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análise da conformidade de rótulos em diferentes marcas de chás comercializados em João Pessoa
Authors: Sousa Aleson Pereira de , Fernandes Amanda Vitória Furtado de Abrantes , Lima Carolina Uchôa Guerra Barbosa de , Ferreira Maria Denise Leite , Nascimento Yuri Mangueira do , Lima Iohanna Patrícia Gouveia , Vasconcelos Mateus Henrique Sales Alves de 
Published: August 2023

De acordo com a Resolução da Diretoria Colegiada (RDC) nº 277 de 22 de setembro de 2005, o chá pode ser definido como: “[...] é todo produto constituído de uma ou mais partes de espécie(s) vegetal(is) inteira(s), fragmentada(s) ou moída(s), com ou sem fermentação, tostada(s) ou não”. Atualmente, os chás são uma das bebidas mais conhecidas e consumidas no mundo, o seu uso atua como uma forma opcional na terapia de algumas doenças, sendo assim considerados como fitoterápicos, e também pela sua capacidade de apresentar em sua composição compostos nutracêuticos, podendo também ser considerados como alimentos. Dessa forma, esse trabalho tem como objetivo geral, analisar a conformidade de rótulos em diferentes marcas de chás comercializados na cidade de João Pessoa - PB. Realizando para tal, um estudo de caráter analítico, experimental, qualitativo e quantitativo, onde as amostras de chás foram selecionadas aleatoriamente em um universo de marcas populares comercializadas em lojas de produtos naturais, supermercados e farmácias do município, entre os meses de julho e agosto de 2022. De acordo com as análises feitas, todos os 16 chás analisados são considerados alimentos, pois, devido a perda de alguns nutrientes e de metabolitos secundários no processo de industrialização, o seu possível efeito terapêutico pode ser anulado, não podendo ser caracterizado como um medicamento fitoterápico. No que se refere aos chás industrializados considerados como alimentos, as leis devem ser adotadas de acordo como a RDC nº 259, de 20 de setembro de 2002, e pela RDC nº 277, de 22 de setembro de 2005. Foi observado que dos 16 rótulos que foram analisados haviam discordância em alguns termos, tendo um em comum entre todas as amostras, em todos chás a denominação “Chá” estava presente, junto a essa denominação deveria vir a expressão "Solúvel", no qual, nenhum desses chás apresentam. Além disso, foi analisado se havia presença de alguns metabolitos secundários como os alcaloides, flavonoides e as saponinas, e com isso foi notado que, devido ao seu processo de fabricação e industrialização alguns desses metabolitos podem ser perdidos. Portanto, é necessária maior fiscalização por parte da Vigilância Sanitária e do MAPA quanto à qualidade, segurança e eficácia dos produtos vegetais e alimentos comercializados nas farmácias, supermercados e/ou comércios, sucedendo em um melhor efeito e utilização por parte do consumidor.
O SERIAL KILLER TED BUNDY, OS CRIMES POR MORDIDAS E A CONTRIBUIÇÃO DAS PERÍCIAS FORENSES: UM ESTUDO DE CASO
Authors: Azevedo Luiza Moura de Souza , Marques Jeidson Antônio Morais 
Published: August 2023

A identificação humana realizada através da perícia dentária é apontada como uma técnica importante e de grande eficácia para solucionar casos de crimes e acidentes, principalmente por causa do elevado número de crimes que acontecem na sociedade contemporânea, além de ser um processo de baixo custo para identificar suspeitos. Assim sendo, quando há marcas de mordidas humanas em vítimas de violência física, essas são provas personalizadas relativas ao autor do crime. Diante desse contexto, o objetivo do trabalho foi realizar um estudo de caso sobre a condenação de Ted Bundy, assim como a investigação, a produção de provas e contribuição da odontologia forense nesses tipos de caso. Sendo assim, a metodologia adotada no trabalho tem como base a pesquisa bibliográfica, com abordagem qualitativa e descritiva, o tipo de pesquisa também usado foi o estudo de caso. A parte teórica envolve o uso de materiais, como livros, artigos, encontrados em sites de buscas, como: Scielo, Pubmed, Lillacs e Medline, indexados entre os anos de 1980 a 2021. Concluiu-se que as marcas de mordidas podem ser usadas como provas periciais, como no caso de Ted Bundy, que são relevantes os indícios, por apresentarem propriedades exclusivas da arcada dentária do transgressor. Dessa forma, é uma técnica usada pela Odontologia Forense, realizada com a moldagem da mordida sendo eficiente, além de ter baixo custo e de trazer ampla celeridade na investigação criminal, inclusive para a obtenção e exercício da justiça.
FÉ E RAZÃO EM SÃO TOMÁS DE AQUINO E SUA IMPORTÂNCIA NA CONSTRUÇÃO DO CONHECIMENTO E DA FELICIDADE
Authors: BRAZ GOMES SEBASTIÃO 
Published: August 2023

O intuito deste artigo é apresentar uma análise sobre a importância do conceito fé e razão, ao longo da história, mas principalmente ob olhar de São Tomás de Aquino, na busca do conhecimento verdadeiro e este como causa primeira para o alcance a felicidade humana. Estes conceitos para alguns são caminhos opostos enquanto a outros produzem harmonia e aminham juntas. Na obra: “Como vejo o mundo”, Albert Einstein faz uma perfeita síntese: “Quem diz que a religião não se armoniza om a ciência é ignorante tanto de uma, quanto de outra”.
FEATURES OF CURRENT ACUTE CORONARY OF A SYNDROME/ACUTE MYOCARDIAL INFARCTION AT THE WOMEN IN ONE OF AREAS OF CITY OF TASHKENT (fragment of the register ACS/AMI)
Authors: Abidova D. E. , Mamutov R. Sh. , Urinov O. U. , Bekbulatova I. R. 
Published: August 2023

Objective. The questions of female health last years get the increasing urgency cardiovascular disease occupy a leading place in structure смертности from the women in the different countries. Often risk of development cardiovascular disease at the women is underestimated, mainly because their first displays at the women develop approximately for 10 years later, than at the men. However given Fremingem of research testify to that that, despite of smaller frequency ишемической of coronary heart disease (CHD) at the women, mortality at them is higher, than at the men.Aim. To study features of development and current acute coronary syndrome and acute myocardial infarction at the women in various age groups in one of areas of. Tashkents (on the data of the register). Methods. 219 women, which average age = 59,48±7,51 years were switched on in research. The data received in past research" The Register acute coronary syndrome and a acute myocardial infarction in one of areas of were analyzed. Tashkents " for 2009 -2010 years. The preventive, statistical, mathematical methods of research were used.Results. The results of our research have shown, that asymptomatic the debut of disease was marked in 1 (0,7%) case the isolated pain in thoracal to a crate was fixed at 3 (2,1%) пациенток, the combination of this symptom with dyspnea met at 7 (4,9%), weakness - at 20 (13,9%), and with cold then - at 1 (0,7%) patient. The presence dyspnea, in a combination to weakness was registered at 10 (6,9%), and dyspnea with cold then - at 2 (1,4%) patients. The weakness as the isolated symptom met at 2 (1,4%) patients. A combination of four symptoms: pain in a breast, dyspnea, weakness and cold sweat were registered at 16 (11,1%) patients. Pain, dyspnea, syncope and cold sweat marked 1 (0,7%) woman.Conclusion.The results of our research have shown, that in process of increase of age at the women the growth acute coronary of pathologies is observed. Most often ACS/AMI develops at the women in age group 60-64 and 65-69 years. The analysis on risk factor (RF) as a whole on group has shown, that most widespread from them were AH and superfluous weight of a body. At the young women conducting risk factors have appeared smoking and obesity. With age the role such a RF, as AH, diabetes mellitus (DM) and hypercholesterolemia is increased. The low adherence to treatment and low level of knowledge is shown concerning acute coronary of a pathology.
HOW TO SELECT CORONARY WIRE FOR ANTEGRADE RECANALIZATION OF CHRONIC TOTAL OCCLUSIONS
Authors: Stelmashok V. J. , Polonetsky O. L. , Strygo N. P. , Zatsepin A. O. , Mrochek A. G. 
Published: August 2023

Aim. To define principles of coronary wire choice during coronary artery chronic total occlusion (CTO) recanalization by antegrade approach. Material and methods. From 2009 to 2013 the attempt of coronary artery CTO recanalization by antegrade approach was undertaken for 217 patients. Depending on success of CTO crossing by coronary wire patients were divided into 2 groups: group 1 (n=164) - successful wire crossing, group 2 (n=53) -unsuccessful attempt of CTO recanalization by coronary wire.Results. In the group 2 there were more frequent CTO localization in the right coronary artery (p<0,05 as compared to group 1), presence of blunt stump, higher frequency of side branches in the zone of proximal CTO cup, and large CTO length (p<0,001 as compared to group 1). CTO recanalization in 47% cases begun from soft wire with polymeric coating and tapered tip, successful recanalization by these wire type was achieved in 49,02% patients. Using non-tapered tip intermediate stiffness wire as the first choice wire was associated with the failure of recanalization (p=0,0440 in intergroup comparison). At impossibility of CTO recanalization by soft wire with polymeric coating and tapered tip used as a first choice, it replacement on non-tapered tip intermediate stiffness wire allowed to achieve successful recanalization in 36,67% patients. In the cases of this strategy uneffectiveness using stiff wire with polymeric coating and tapered tip as a third choice allowed additionally to attain successful recanalization in 60% cases. Replacement of the soft wire with polymeric coating and tapered tip on stiff wire with polymeric coating and tapered tip, executable at presence of meaningful rigidity in the proximal CTO cup zone associated with the achievement the successful recanalization in 60% cases.Conclusion. On the basis of the obtained data it was created the conception of step-up wire stiffness increase during the CTO recanalization by antegrade approach.
EFFICACY OF A FIXED COMBINATION OF LOSARTAN AND AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION: SEASONAL FEATURES
Authors: Smirnova M. D. , Fofanova T. V. , Blankova Z. N. , Vitsenya M. V. , Tsybulskaya T. V. , Dianova Yu. F. , Ageev F. T. 
Published: August 2023

The goal is to evaluate the efficacy and security of treatment of patients with arterial hypertension (AH) during the heat wave of a fixed combination of ARBS+ACC (losartan+amlodipine).Materials and methods. Included 26 patients with hypertension 1 and 2 degrees from 42 to 81 years. All patients underwent measurement of office blood pressure, 24h ambulatory BP monitoring, Self-measurement of BP (Home BP ), electrocardiography, biochemical analysis of blood, estimation of osmolarity of blood, questionnaire: visual analogue scale, a questionnaire for patients exposed to heat, the test of adherence to treatment Moriscos-Green. Estimated diaries of self-control of blood pressure. The inclusion visit took place in spring 2016, 1st visit was in May-June 2016, 2nd - during heat waves, 3rd -September-October 2016.Results. The observed decrease in systolic blood pressure and diastolic blood pressure (p=0.000) to the target values, preserved for the whole period of observation. According to the diaries of selfcontrol of blood pressure controlled blood pressure 81% of patients. During a heat wave, this value decreased to 58%, in autumn - to 63%. The 3rd visit achieved a reduction in heart rate at -6.0 (-11.1; and 2.8) beats/min; p=0.007; the decline in uric acid level c of 415.3 to 346.2 mmol/l (p=0.04) and creatinine on the 2nd visit compared to baseline (p=0.02). According to 24h ambulatory BP monitoring, 24h ambulatory BP monitoring, during a single visit, the mean SBP decreased from 139 to 121 mm Hg. (P=0.04) and DBP from 88 to 76 mm Hg. (P=0.04) in the daytime and the tendency to decrease SBP variability from 12 to 10 mm (p=0.07). At the end of the study, the indicators remained stable. The mean value of SBP decreased at night to the third visit from 116 to 110.5 mm Hg. (P=0.04). During the heat wave, a larger mean SBP and DBP was recorded compared with the third visit (p=0.04). A correlation was found between the mean DBP value (r=0.725, p=0.03), the SBP time index (r=0.695, p=0.04) and the SBP time (r=0.787, p=0.02) at night and Quality of life Electrolyte shifts and increasing the osmolarity of the blood during heat waves have not been identified. There is a growing commitment therapy (p=0.04) and quality of life to 20.0 (7.4; 23.3); p=0.000 by visual analogue scale.Conclusion. Fixed combination of losartan and amlodipine (Lorenza) is an effective, safe and may be recommended for hypertensive patients during heat wave and seasonal cold snap.
SHAPE OF CALCIUM PHOSPHATE BIONS DEFINES A PROATHEROSCLEROTIC SHIFT IN CYTOKINE SECRETION PROFILE OF ENDOTHELIAL CELLS
Authors: Kutikhin A. G. , Velikanova E. A. , Shishkova D. K. 
Published: August 2023

Study aim. To investigate whether the shape of calcium phosphate bions (CPB) affects their endothelial toxicity via evaluating the cytokine secretion profile of endothelial cells upon the exposure to either spherical or spindle-shaped CPB.Material and methods. For the experiments, we used an immortalized human vein endothelial cell line EA.hy 926. Cells were seeded into 6-well plates (3*105 cells) with the further: 1) addition of 100 |jL either spherical CPB, spindle-shaped CPB, or 1x phosphate buffered saline (PBS) upon 1 h following culture for 24 h (non-confluent cell culture); 2) culture for 44 h and subsequent addition of 100 jL either spherical CPB, spindle-shaped CPB, or PBS following culture for 4 h (confluent cell culture). Upon the collection of cell culture supernatant (n=11 wells per group), the levels of proatherosclerotic cytokines (interleukin (IL)-1ß, IL-6, IL-8, IL-10, IL-12, IL-23, tumor necrosis factor (TNF)-a, interferon (IFN)-y, and soluble vascular cell adhesion molecule (sVCAM)-1) were measured utilizing an enzyme-linked immunosorbent assay.Results. In a non-confluent cell culture, exposure to spindleshaped CPB increased the secretion of several proatherosclerotic cytokines (IL-1 ß, IL-10, IL-12, IL-23, IFN-y) compared to either spherical CPB-treated or control cells. In a confluent cell culture, exposure to either of CPB types decreased the release of IL-1 ß, IL- 10, and IFN-y; however, their concentration was still higher upon the exposure to spindle-shaped CPB in comparison with exposure to spherical CPB. Discriminant analysis and principal component analysis demonstrated that the cytokine secretion profile of spindle-shaped CPB-treated endothelial cells significantly differed from those of either spherical CPB-treated or control cells.Conclusion. Spindle-shaped CPB induce the secretion of proatherosclerotic cytokines by endothelial cells compared to spherical CPB; this suggests higher endothelial toxicity of spindleshaped CPB.
FEATURES OF THE RESPONSE OF ARTERIAL BLOOD FLOW TO THE ORTHOSTATIC LOAD IN YOUNG WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION
Authors: Agafonova T. Y. , Baev V. M. , Samsonova O. A. , Dusakova R. S. 
Published: August 2023

The aim of the study was to evaluate the response of arterial blood flow to the orthostatic load in young women with idiopathic arterial hypotension (IAH).Material and methods. A comparative analysis of systemic hemodynamics and peripheral arterial blood flow parameters was performed for orthostasis between two groups of women aged 1825: test with IAH (n = 73) and control (n=37). The SBP level in the test group was 90-98 mm Hg, in the control group - 120-129 mm Hg. BP, heart rate and angio-scanning were performed twice: at rest, lying after 15 minutes rest and during the first minute of orthostasis. Blood flow was studied in the right vertebral, radial and posterior tibial arteries. The following parameters were evaluated: diameter during diastole, peak systolic and terminal diastolic blood flow velocity.Results. In young women with IAH, as those with normal arterial pressure, orthostasis was accompanied by an increase in SBP, DBP and an increase in heart rate. With hypotension, an increase in the diameter of the vertebral artery and a decrease in the diameter of the posterior tibial artery were detected. In both groups, orthostasis was accompanied by a decrease in the rate of blood flow, both during systole and diastole.The conclusion. Orthostasis with IAH is accompanied by an increase in SBP, DBP and heart rate. The response of peripheral arteries to orthostasis is characterized by a change in the diameter of the vessels, which indicates a pronounced adaptive response to the physiological stress load.
EVALUATION OF DEFORMATION OF THE LEFT VENTRICLE AND LEFT ATRIUM, AND THE ROTATIONAL PROPERTIES OF THE LEFT VENTRICLE IN PATIENTS WITH CHF ACCORDING TO THE ECHOCARDIOGRAPHIC TECHNOLOGY OF NON-DOPPLER IMAGING IN TWO AND THREE-DIMENSIONAL REGIMENS
Authors: Sohibnazarova V. K. , Saidova M. A. , Tereshchenko S. N. , Belevskaya A. A. 
Published: August 2023

Objective. To study the peculiarities of deformation, rotation properties, twisting and untwisting of the left ventricular(LV), evaluation of the function of left atrium in patients with CHF with preserved and reduced ejection fraction of the left ventricular according to Echocardiography technology Non Doppler imaging in two and three-dimensional regimes (2D and 3D Speckle tracking imaging).Material and methods. The study included 70 patients with chronic heart failure (CHF) with preserved (Group I) and reduced (Group II) ejection fraction (EF) of the left ventricular (LV). In addition to the standard Transthoracic echocardiography, all patients were assessed the deformation of the left ventricle (LV) and left atrium (LA) as well as the rotational properties of the LV using the technology of myocardial image in two and threedimensional regimen.Results. Studies show that patients CHF deformation of the left ventricular (LV) and left atrium (LA), and the rotational properties, twisting and unwinding of the (LV) according to the two methods were lower than the control group (CG). In both groups there was a reliable increase the size and volume of LA, as well as a decrease the deformation of the LA in it phases and global longitudinal deformation. The values of the global longitudinal deformation of the LA in patients group I and II (-6,68±3.0% and-6,63±3.3%, respectively) were reliably lower compared to CG (-9.3±7.3%) (p <0.001). A good correlation was found between LV deformation and LV EF in patients group I (r = -0.39) ( p <0.001) and in group II (r = 0.35)(p <0.001).Conclusions. When estimating the deformation of the left ventricular according to the data of two technologies, the threedimensional mode demonstrated lower myocardial deformation in comparison with the three dimensional regime, which may be associated with a fuller assessment of the deformation of the left ventricular myocardium. Also increased global longitudinal deformation of LA can be an early predictor of diagnostics of CHF.
NOSOLOGICAL STRUCTURE OF ACUTE CORONARY EVENTS AT ADMISSION AND AT DISCHARGE, PATIENT COMPLIANCE AND NEAREST FORECAST (DATA OF THE RACSMI-UZ REGISTER)
Authors: Nagaeva G. A. 
Published: August 2023

Introduction. Basing on the data of the “RACSMI-UZ” register, the article provides comparative analysis of the structure and transformation of diagnoses during acute coronary conditions in the dynamics (at admission and discharge), assesses patients' adherence to drug therapy depending on gender and also describes analysis of its effect on the short-term prognosis.Material and methods. The study material included 449 patients with ACS/AMI hospitalized to relevant health care facilities of the experimental district of Tashkent. Two groups of patients were distinguished depending on the gender: group 1 included 243 male patients, and group 2 consisted of 206 female patients. Results. The registration showed that ACS/AMI was more often observed in men than in women (54.1% vs. 45.9%, respectively). Male patients proved to be younger than female ones (p <0.05); obesity of different degree prevailed in women (48.0% in women vs. 29.6% in men, p <0.05). In the male population, AMI at admission was registered in 43 (17.7%) patients but the number of patients with this diagnosis increased at discharge (61 subjects, or 25.1%). Out of 243 men, 3.7% died and the largest number of deaths occurred in patients with initial diagnosis of unstable angina. In the female population, the incidence of AMI both with and without Q at admission was recorded 2 times less frequent than that at discharge from the hospital (8.7% of cases at admission and 17.5% of cases at discharge), which shows low vigilance of healthcare professionals in diagnostics of AMI in women. Mortality from ACS/ AMI in women was 3.4% with the largest number of deaths being associated with the initial diagnosis of AMI without Q. Compliance in females was somewhat higher than in males; men were prone to taking more medications (Mc’s), though there were no significant differences between men and women by the proportion of Mc’s taken. The direct correlation was found between the patients’ compliance level and the time interval: from admission to death of the respondent (p> 0.05).Conclusion. ACS / AMI was more often recorded in men than in women, while the age of men was younger (p<0.05). Alertness of primary care physicians in ACS / AMI was low, especially for women. Compliance in women was higher than in men. Thus, the higher was the patient adherence to therapy, the more stable the body appeared to cardio stress.