bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using time travel in virtual reality (VR) to increase efficacy perceptions of influenza vaccination
Authors: Lee Joomi , Wu Dai-Yun , Lin Jih-Hsuan (Tammy) , Kim Jooyoung , Ahn Sun Joo (Grace) 
Published: May 2023

Abstract
This study examined the unique affordance of time travel in virtual reality (VR) to enhance the perceived efficacy of influenza vaccination. Effective vaccine communication hinges on raising awareness of the risk of contracting a contagious virus and spreading the infection to others. According to the extended-parallel process model, behavioral changes are achieved when an individual perceives sufficient levels of threat and efficacy to prevent negative health outcomes. Findings from a 2 (interactivity: active vs. passive) × 2 (virtual time travel: yes vs. no) between-subjects experiment (N = 178) indicated that virtual time travel to receive vaccination after experiencing negative consequences of influenza in VR increased participants’ perceived efficacy of vaccination for self-protection and community protection. Moreover, interactivity in VR enhanced vaccination intention, mediated by spatial presence, message involvement, and response efficacy.
Elucidating the insecticidal mechanisms of zein nanoparticles on Anticarsia gemmatalis (Lepidoptera: Erebidae)
Authors: Bonser Colin A R , Astete Carlos E , Sabliov Cristina M , Davis Jeffrey A 
Published: May 2023

Abstract
Previous research suggested that positively charged zein nanoparticles [(+)ZNP] were toxic to neonates of Anticarsia gemmatalis Hübner and deleterious to noctuid pests. However, specific modes of action for ZNP have not been elucidated. Diet overlay bioassays attempted to rule out the hypothesis that A. gemmatalis mortality was caused by surface charges from component surfactants. Overlay bioassays indicated that negatively charged zein nanoparticles [(−)ZNP] and its anionic surfactant, sodium dodecyl sulfate (SDS), exhibited no toxic effects when compared to the untreated check. Nonionic zein nanoparticles [(N)ZNP] appeared to increase mortality compared to the untreated check, though larval weights were unaffected. Overlay results for (+)ZNP and its cationic surfactant, didodecyldimethylammonium bromide (DDAB), were found to be consistent with former research indicating high mortalities, and thus, dosage response curves were conducted. Concentration response tests found the LC50 for DDAB on A. gemmatalis neonates was 208.82 a.i./ml. To rule out possible antifeedant capabilities, dual choice assays were conducted. Results indicated that neither DDAB nor (+)ZNP were antifeedants, while SDS reduced feeding when compared to other treatment solutions. Oxidative stress was tested as a possible mode of action, with antioxidant levels used as a proxy for reactive oxygen species (ROS) in A. gemmatalis neonates, which were fed diet treated with different concentrations of (+)ZNP and DDAB. Results indicated that both (+)ZNP and DDAB decreased antioxidant levels compared to the untreated check, suggesting that both (+)ZNP and DDAB may inhibit antioxidant levels. This paper adds to the literature on potential modes of action by biopolymeric nanoparticles.
Reproductive biology of overwintering leaffooted bug Leptoglossus zonatus (Hemiptera: Coreidae) in California
Authors: Stahl Judith M , Daane Kent M 
Published: May 2023

Abstract
Leptoglossus zonatus (Dallas) (Hemiptera: Coreidae) is a polyphagous insect pest attacking a wide variety of crops. In California’s Central Valley, it is now the dominant leaffooted bug on almonds, pistachios, and pomegranates. Leptoglossus zonatus pest status depends largely on overwintering adult survival and reproductive potential, which determines its population size in spring and early summer when nut crops are particularly susceptible to bug damage. Here, we investigated the overwintering reproductive biology of L. zonatus in laboratory and field experiments to gain information about its ovary development, time of mating, and the impact of low temperatures on egg hatch. With dissections of laboratory-reared L. zonatus, we established a baseline for ovarian development and determined that the size of the spermathecal reservoir is larger in mated than in unmated females. Dissections and behavioral experiments of field-collected material provided evidence of mating events before dispersal from overwintering sites. Laboratory trials showed that temperature significantly impacted L. zonatus egg hatch. Leptoglossus zonatus reproductive biology presented provides valuable information on its population dynamics and dispersal from overwintering sites, and will contribute to the development of monitoring and management tools.
Understanding Russia’s Actions in Ukraine as the Crime of Genocide
Authors: Azarov Denys , Koval Dmytro , Nuridzhanian Gaiane , Venher Volodymyr 
Published: May 2023

Abstract
The new wave of Russia’s aggression against Ukraine that began on 24 February 2022, and the intensification of the armed conflict accompanied by grave breaches of international humanitarian law, has received significant scholarly attention. Many academic interventions have examined the developments in Ukraine through the frameworks of jus ad bellum and jus in bello. Some, however, have applied a genocide lens to make sense of reported numerous and widespread violations of international humanitarian and human rights law. This article contributes to the latter stream of scholarship by contextualizing the arguments for the existence of genocidal intent behind the seemingly unrelated crimes committed by the armed forces of the Russian Federation all over Ukraine. The authors pay particular attention to the language and pseudo-historical references used by Russia’s leaders as a justification for the invasion of Ukraine and argue that these statements and expressions indicate the existence of genocidal intent. This article also reflects on the issue of the systematic destruction of cultural heritage of Ukraine as further evidence of the intent to destroy the Ukrainian nation understood as a protected national group under the Genocide Convention, at least in part. Finally, the authors analyse the genocidal acts that have apparently been committed, including killings; the causing of serious bodily or mental harm; the forcible transfer of Ukrainian children to Russia, and the deliberate infliction of conditions of life aimed at the physical destruction of the Ukrainian nation. It is stressed that there are reasonable grounds to believe that the destruction of the Ukrainian nation by Russia has been pursued through commission of these prohibited acts. Their nature and large-scale character serve as further evidence of genocidal intent to destroy the Ukrainian nation.
Democratic Justifications for Patient Public Involvement and Engagement in Health Research: An Exploration of the Theoretical Debates and Practical Challenges
Authors: Frith Lucy 
Published: May 2023

Abstract
The literature on patient public involvement and engagement (PPIE) in health research has grown significantly in the last decade, with a diverse range of definitions and topologies promulgated. This has led to disputes over what the central functions and purpose of PPIE in health research is, and this in turn makes it difficult to assess and evaluate PPIE in practice. This paper argues that the most important function of PPIE is the attempt to make health research more democratic. Bringing this function to the fore and locating PPIE in the wider context of changes in contemporary forms of democratic engagement provides greater conceptual clarity over what PPIE in research should be trying to achieve. Conceptualizing PPIE as a form of democratization has a number of benefits. First, theories of what are appropriate, normatively justifiable and workable criteria for PPIE practices can be developed, and this can provide tools to address the legitimacy and accountability questions that have troubled the PPIE community. Second, this work can be used to form the basis of a research agenda to investigate how PPIE in health research operates, and how it can facilitate and/or improve democratic processes in health research.
Inconsistency between the Circulatory and the Brain Criteria of Death in the Uniform Determination of Death Act
Authors: Molina-Pérez Alberto , Bernat James L , Dalle Ave Anne 
Published: May 2023

Abstract
The Uniform Determination of Death Act (UDDA) provides that “an individual who has sustained either (1) irreversible cessation of circulatory and respiratory functions or (2) irreversible cessation of all functions of the entire brain, including the brain stem, is dead.” We show that the UDDA contains two conflicting interpretations of the phrase “cessation of functions.” By one interpretation, what matters for the determination of death is the cessation of spontaneous functions only, regardless of their generation by artificial means. By the other, what matters is the cessation of both spontaneous and artificially supported functions. Because each UDDA criterion uses a different interpretation, the law is conceptually inconsistent. A single consistent interpretation would lead to the conclusion that conscious individuals whose respiratory and circulatory functions are artificially supported are actually dead, or that individuals whose brain is entirely and irreversibly destroyed may be alive. We explore solutions to mitigate the inconsistency.
Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C
Authors: Chi Susan N , Yi Joanna S , Williams P Mickey , Roy-Chowdhuri Sinchita , Patton David R , Coffey Brent D , Reid Joel M , Piao Jin , Saguilig Lauren , Alonzo Todd A , Berg Stacey L , Ramirez Nilsa C , Jaju Alok , Mhlanga Joyce C , Fox Elizabeth , Hawkins Douglas S , Mooney Margaret M , Takebe Naoko , Tricoli James V , Janeway Katherine A , Seibel Nita L , Parsons D Williams 
Published: May 2023

Abstract

Background
National Cancer Institute-Children’s Oncology Group Pediatric Molecular Analysis for Therapy Choice assigns patients aged 1-21 years with refractory solid tumors, brain tumors, lymphomas, and histiocytic disorders to phase II trials of molecularly targeted therapies based on detection of predefined genetic alterations. Patients whose tumors harbored EZH2 mutations or loss of SMARCB1 or SMARCA4 by immunohistochemistry were treated with EZH2 inhibitor tazemetostat.

Methods
Patients received tazemetostat for 28-day cycles until disease progression or intolerable toxicity (max 26 cycles). The primary endpoint was objective response rate; secondary endpoints included progression-free survival and tolerability of tazemetostat.

Results
Twenty patients (median age = 5 years) enrolled, all evaluable for response and toxicities. The most frequent diagnoses were atypical teratoid rhabdoid tumor (n = 8) and malignant rhabdoid tumor (n = 4). Actionable alterations consisted of SMARCB1 loss (n = 16), EZH2 mutation (n = 3), and SMARCA4 loss (n = 1). One objective response was observed in a patient with non-Langerhans cell histiocytosis with SMARCA4 loss (26 cycles, 1200 mg/m2/dose twice daily). Four patients with SMARCB1 loss had a best response of stable disease: epithelioid sarcoma (n = 2), atypical teratoid rhabdoid tumor (n = 1), and renal medullary carcinoma (n = 1). Six-month progression-free survival was 35% (95% confidence interval [CI] = 15.7% to 55.2%) and 6-month overall survival was 45% (95% CI = 23.1% to 64.7%). Treatment-related adverse events were consistent with prior tazemetostat reports.

Conclusions
Although tazemetostat did not meet its primary efficacy endpoint in this population of refractory pediatric tumors (objective response rate = 5%, 90% CI = 1% to 20%), 25% of patients with multiple histologic diagnoses experienced prolonged stable disease of 6 months and over (range = 9-26 cycles), suggesting a potential effect of tazemetostat on disease stabilization.
Drivers of Loneliness among Older Refugees
Authors: Horn Vincent , Fokkema Tineke 
Published: May 2023

AbstractAlthough older refugees can be seen as particularly vulnerable to social isolation and loneliness, they are often overlooked by ageing and migration scholars. This article addresses this research gap by identifying and examining potential drivers of loneliness among older refugees. The study analysed data from the first two waves of the IAB-BAMF-SOEP Survey of Refugees, focusing on 958 individuals aged 45 and older who arrived in Germany between 2013 and 2016. Nearly half of the participants reported symptoms of loneliness. The major contributing factors included poor health, financial strain, lack of family ties in Germany, limited contact with Germans, insecure residence status, and perceived hostility towards them. The study highlights the need for a range of interventions at multiple levels targeting not only the older refugees themselves but also institutional arrangements and the people of the host country.
Bisphosphonate-treatment of secondary chronic osteomyelitis of the jaw – a case report
Authors: Heimes Diana , Kämmerer Peer W 
Published: May 2023

Abstract
Secondary chronic osteomyelitis (SCO) is caused by bacterial infection leading to progressive jawbone destruction. Antibiotics are used as first-line treatment; surgical therapy is usually extensive and may not provide a cure. Bisphosphonates have been reported to be successful in patients with primary nonbacterial osteomyelitis, and literature indicates promising results in SCO. A 38-year-old patient presented with a progressive mandible-destruction 17 years after wisdom tooth extraction. Several treatment attempts have been unsuccessful. Seeking a second opinion, the patient was then interdisciplinary treated with 90 mg of intravenous pamidronate every four weeks, three times. The patient did not experience side effects presenting a considerable improvement in mouth opening and reporting a dissolvent of signs of pain or infection. The MRI showed edema reduction and decreased contrast uptake. Therefore, bisphosphonate treatment of secondary chronic osteomyelitis of the jaw is a safe and effective option in selected cases after unsuccessful first- and second-line therapy.
Automated Classification for Open-Ended Questions with BERT
Authors: Gweon Hyukjun , Schonlau Matthias 
Published: May 2023

Abstract
Manual coding of text data from open-ended questions into different categories is time consuming and expensive. Automated coding uses statistical/machine learning to train on a small subset of manually-coded text answers. Recently, pretraining a general language model on vast amounts of unrelated data and then adapting the model to the specific application has proven effective in natural language processing. Using two data sets, we empirically investigate whether BERT, the currently dominant pretrained language model, is more effective at automated coding of answers to open-ended questions than other non-pretrained statistical learning approaches. We found fine-tuning the pretrained BERT parameters is essential as otherwise BERT is not competitive. Second, we found fine-tuned BERT barely beats the non-pretrained statistical learning approaches in terms of classification accuracy when trained on 100 manually coded observations. However, BERT’s relative advantage increases rapidly when more manually coded observations (e.g., 200–400) are available for training. We conclude that for automatically coding answers to open-ended questions BERT is preferable to non-pretrained models such as support vector machines and boosting.
On Getting it Wrong
Authors: Lemma Alessandra 
Published: May 2023

Abstract
This chapter discusses the importance of recognizing the ubiquity of therapist error and treatment failures. It considers different forms of ‘when things go wrong’ in an analytic dyad. This can cover, for example, misjudgements, lapses in attention or moments of misattunement. The term ‘violation’ is reserved to describe actual physical and/or sexual transgressions and sustained emotional abuse of the patient to meet the therapist’s own needs. Within the broad category of ‘getting it wrong’, two types of ethical breaches are distinguished: one that leads to fracture, that is it breaks the analytic relationship irreparably; the other creates a relational gap, which if mentalized, can potentially be transformed into an opening that adds perspective to the work of therapy. The chapter discusses occupational risks around boundary issues (fees, confidentiality, and endings) and the specific ethical risks of online therapy.
Principles in Action
Authors: Lemma Alessandra 
Published: May 2023

Abstract
By way of an illustration of applied ethics, Chapter 7 focuses in some detail on the author’s experience of how an applied ethics approach helped her to find a psychoanalytic position in relation to working with transgender young people. Consideration of the ethics of ‘conversion therapy’ further illustrates the process and merits of systematic ethical analysis. These examples serve as reminders of the importance of prioritizing the patient’s personal values to mitigate the dangers of a normative ideology guiding the analytic process whilst retaining the integrity of the therapist’s own understandings and values, which may differ from the patient’s. The chapter also critically examines the ‘interpretation of the transference’ as an example of the importance of questioning what drives adherence to the analytic techniques that are privileged and how this can be ethically compromising.
Developing the Ethical Chóros
Authors: Lemma Alessandra 
Published: May 2023

Abstract
Existing training in ethics mostly approximates the ‘ethical floor’ approach with, at one end, a focus on minimal obligations and, at the other end, a near-exclusive focus on the more egregious violations. This leaves a relative void in-between. This approach to teaching ethics is not adequate for our purposes. Instead this chapter argues the case for the allocation of space during training for consideration of the more everyday errors, ethical dilemmas, and breaches. This chapter focuses on ‘how’ we could teach ethics to increase protection for patients and ensure that teaching ethics does not become token. It is all too easy to dilute the real demand that the call to ethics places on the therapist. Rules and codes of ethics cannot protect the patient against the operation of the therapist’s unconscious. A detailed curriculum is set out with specified readings. It is suggested that the quality of a training is largely determined by what candidates are encouraged to question in themselves, in the analytic method, and in their institutions.
Operation Bushmaster: The Impact of Simulation-Based Education on Preparing the Next Generation of Military Medical Officers
Authors: Rudinsky CAPT Sherri L , Schwartz LTC James 
Published: May 2023

ABSTRACT
Operation Bushmaster, a large-scale, immersive, multiday simulation experience, is the capstone event of the School of Medicine’s four-year longitudinal Military Unique Curriculum. Operation Bushmaster creates a realistic, far-forward deployed environment where military health profession students are provided the opportunity to put their military medical knowledge, skills, and abilities into practice. This use of simulation-based education is essential to accomplishing Uniformed Services University’s mission—to educate and train military health profession students to serve as future military health officers and leaders within the Military Health System. Simulation-based education (SBE) is effective in reinforcing operational medical knowledge and patient care skills. Additionally, we found SBE can be employed to develop other key competencies for military health care professionals such as professional identity formation, leadership, self-confidence, decision-making under stress, communication, and interpersonal collaboration. This special edition of Military Medicine highlights the educational impact of Operation Bushmaster on the training and development of future uniformed physicians and leaders within the Military Health System.
Simultaneous radio and X-ray observations of the magnetar Swift J1818.0−1607
Authors: Bansal Karishma , Wharton Robert S , Pearlman Aaron B , Majid Walid A , Prince Thomas A , Younes George , Hu Chin-Ping , Enoto Teruaki , Kocz Jonathon , Horiuchi Shinji 
Published: May 2023

ABSTRACT
Swift J1818.0−1607 is a radio-emitting magnetar that was discovered in X-ray outburst in 2020 March. Starting 4 d after this outburst, we began a nearly 5-month multifrequency observing campaign at 2.2, 8.4, and 32 GHz using telescopes in the NASA Deep Space Network. Using a dual-frequency observing mode, we were able to observe Swift J1818.0−1607 simultaneously at either 2.2 and 8.4 GHz or 8.4 and 32 GHz. Over the course of the campaign, we find that the flux density increases substantially and the spectrum changes from uncharacteristically steep (α &lt; −2.2) to the essentially flat (α ≈ 0) spectrum typical of radio-emitting magnetars. In addition to the expected profile evolution on time-scales of days to months, we find that Swift J1818.0−1607 also exhibits mode switching where the pulse profile changes between two distinct shapes on time-scales of seconds to minutes. For two of the radio observations, we also had accompanying X-ray observations using the Neutron Star Interior Composition Explorer telescope that occurred on the same day. We find a near anti-alignment (0.40 phase cycles) between the peaks of the radio and X-ray pulse profiles, which is most likely explained by an intrinsic misalignment between the X-ray- and radio-emitting regions.
Filling in the gaps: can gravitationally unstable discs form the seeds of gas giant planets?
Authors: Baehr Hans 
Published: May 2023

ABSTRACT
Circumstellar discs likely have a short window when they are self-gravitating and prone to the effects of disc instability, but during this time the seeds of planet formation can be sown. It has long been argued that disc fragmentation can form large gas giant planets at wide orbital separations, but its place in the planet formation paradigm is hindered by a tendency to form especially large gas giants or brown dwarfs. We instead suggest that planet formation can occur early in massive discs, through the gravitational collapse of dust which can form the seeds of giant planets. This is different from the usual picture of self-gravitating discs, in which planet formation is considered through the gravitational collapse of the gas disc into a gas giant precursor. It is familiar in the sense that the core is formed first, and gas is accreted thereafter, as is the case in the core accretion scenario. However, by forming a ∼1 M⊕ seed from the gravitational collapse of dust within a self-gravitating disc there exists the potential to overcome traditional growth barriers and form a planet within a few times 105 yr. The accretion of pebbles is most efficient with centimetre-sized dust, but the accretion of millimetre sizes can also result in formation within a Myr. Thus, if dust can grow to these sizes, planetary seeds formed within very young, massive discs could drastically reduce the time-scale of planet formation and potentially explain the observed ring and gap structures in young discs.