bluuebunny/crossref_metadata_2025_split huggingface dataset:
Head in the clouds, feet on the ground: how transdisciplinary learning can foster transformative change—insights from a summer school
Authors: Atienza Casas Sara , Calicis Camille , Candiago Sebastian , Dendoncker Nicolas , Desair Jomme , Fickel Thomas , Finne Eirik Aasmo , Frison Christine , Haensel Maria , Hinsch Malte , Kulfan Tyler , Kumagai Joy A. , Mialyk Oleksandr , Nawrath Maximilian , Nevzati Fiona , Washbourne Carla , Wübbelmann Thea 
Published: May 2023

AbstractThere is a pressing need for transformative change, with a vision of long-term human well-being within planetary boundaries. The lack of progress—despite increasing awareness and action—illustrates how challenging it is to foster change in our complex global society. Education and learning are needed to enable change. Transdisciplinary learning, which meaningfully integrates diverse knowledge and perspectives, contributes to developing an integrative understanding—a necessity for tackling complex challenges. We explore how transdisciplinary learning for early-career researchers can foster transformative change and lead to increased biodiversity conservation. This paper focuses on a case study of the authors’ shared experiences during the 2021 Alternet Summer School, which focused on transformative change for biodiversity conservation and human well-being. In this introspective research, we gained insights through an online survey for participants and organizers of the summer school (n = 27). Using qualitative content analysis, we identify seven crucial elements of transdisciplinary learning which can lead to transformative change on (a) a personal level, as the learning process shifts values and helps researchers identify their roles; (b) a research level, by rethinking science and providing tools for transdisciplinary approaches, and (c) a societal level, by moving from the individual to the collective and constructing a shared vision for a sustainable future. Participants highlighted how changes on all these levels could benefit biodiversity conservation. These insights point to the benefit of transdisciplinary learning opportunities that empower young researchers to take up their part in fostering transformative change.
Neural Substrates for Hand and Shoulder Movement in Healthy Adults: A Functional near Infrared Spectroscopy Study
Authors: Bonnal Julien , Ozsancak Canan , Monnet Fanny , Valery Antoine , Prieur Fabrice , Auzou Pascal 
Published: May 2023

AbstractCharacterization of cortical activation patterns during movements in healthy adults may help our understanding of how the injured brain works. Upper limb motor tasks are commonly used to assess impaired motor function and to predict recovery in individuals with neurological disorders such as stroke. This study aimed to explore cortical activation patterns associated with movements of the hand and shoulder using functional near-infrared spectroscopy (fNIRS) and to demonstrate the potential of this technology to distinguish cerebral activation between distal and proximal movements. Twenty healthy, right-handed participants were recruited. Two 10-s motor tasks (right-hand opening-closing and right shoulder abduction-adduction) were performed in a sitting position at a rate of 0.5 Hz in a block paradigm. We measured the variations in oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) concentrations. fNIRS was performed with a 24-channel system (Brite 24®; Artinis) that covered most motor control brain regions bilaterally. Activation was mostly contralateral for both hand and shoulder movements. Activation was more lateral for hand movements and more medial for shoulder movements, as predicted by the classical homunculus representation. Both HbO2 and HbR concentrations varied with the activity. Our results showed that fNIRS can distinguish patterns of cortical activity in upper limb movements under ecological conditions. These results suggest that fNIRS can be used to measure spontaneous motor recovery and rehabilitation-induced recovery after brain injury. The trial was restropectively registered on January 20, 2023: NCT05691777 (clinicaltrial.gov).
Targeting PELP1 oncogenic signaling in TNBC with the small molecule inhibitor SMIP34
Authors: Altwegg Kristin A. , Pratap Uday P. , Liu Zexuan , Liu Junhao , Sanchez John R. , Yang Xue , Ebrahimi Behnam , Panneerdoss Durga Meenakshi , Li Xiaonan , Sareddy Gangadhara R. , Viswanadhapalli Suryavathi , Rao Manjeet K. , Vadlamudi Ratna K. 
Published: May 2023

Abstract
Purpose
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Oncogenic PELP1 is frequently overexpressed in TNBC, and it has been demonstrated that PELP1 signaling is essential for TNBC progression. The therapeutic utility of targeting PELP1 in TNBC, however, remains unknown. In this study, we investigated the effectiveness of SMIP34, a recently developed PELP1 inhibitor for the treatment of TNBC.

Methods
To ascertain the impact of SMIP34 treatment, we used seven different TNBC models for testing cell viability, colony formation, invasion, apoptosis, and cell cycle analysis. Western blotting and RT-qPCR were used to determine the mechanistic insights of SMIP34 action. Using xenograft and PDX tumors, the ability of SMIP34 in suppressing proliferation was examined both ex vivo and in vivo.

Results
TNBC cells’ viability, colony formation, and invasiveness were all decreased by SMIP34 in in vitro cell-based assays, while apoptosis was increased. SMIP34 treatment promoted the degradation of PELP1 through the proteasome pathway. RT-qPCR analyses confirmed that SMIP34 treatment downregulated PELP1 target genes. Further, SMIP34 treatment substantially downregulated PELP1 mediated extranuclear signaling including ERK, mTOR, S6 and 4EBP1. Mechanistic studies confirmed downregulation of PELP1 mediated ribosomal biogenesis functions including downregulation of cMyc and Rix complex proteins LAS1L, TEX-10, and SENP3. The proliferation of TNBC tumor tissues was decreased in explant experiments by SMIP34. Additionally, SMIP34 treatment markedly decreased tumor progression in both TNBC xenograft and PDX models.

Conclusions
Together, these findings from in vitro, ex vivo, and in vivo models show that SMIP34 may be a useful therapeutic agent for inhibiting PELP1 signaling in TNBC.
A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer
Authors: Fan Yu , Zhong Xiaorong , Wang Yu , Wang Zhu , Luo Ting , Wang Yanping , Zheng Hong 
Published: May 2023

Abstract
Purpose
This study aimed to examine the clinical characteristics and outcomes of patients with estrogen receptor-negative (ER−)/progesterone receptor-positive (PR+) early breast cancer. We also aimed to investigate the benefits of adjuvant endocrine therapy (ET) in this patient population.

Methods
Patients with early breast cancer diagnosed at West China Hospital were divided into the ER−/PR+, ER+, and ER−/PR− groups. The chi-square test was used to analyze differences in clinical and pathological features among the groups. Multivariable Cox and Fine–Gray regression models were used to compare mortality and locoregional recurrence (LRR)/distant recurrence (DR), respectively. We performed a subgroup analysis to determine which ER−/PR+ patients can benefit more from ET.

Results
From 2008 to 2020, we enrolled 443, 7104, and 2892 patients into the ER−/PR+, ER+, and ER−/PR− groups, respectively. The ER−/PR+ group showed more unfavorable clinical features and aggressive pathological characteristics than the ER+ group. The mortality, LRR, and DR rates were higher in the ER−/PR+ than in the ER+ group. Most clinical features and pathological characteristics were similar between the ER−/PR+ and ER−/PR− group and their outcomes were comparable. In the ER−/PR+ group, patients who received ET showed significantly lower LRR and mortality rates than those who did not; however, no difference was observed in DR. Subgroup analysis suggested that ER−/PR+ patients age ≥ 55 years, and postmenopausal status can benefit from ET.

Conclusion
ER−/PR+ tumors have more aggressive pathological characteristics and more unfavorable clinical features than ER+ tumors. ET can reduce the LRR and mortality rates in ER−/PR+ patients. Postmenopausal and age ≥ 55 years ER−/PR+ patients can benefit from ET.
Selling visibility-boosts on dating apps: a problematic practice?
Authors: de Vries Bouke 
Published: May 2023

AbstractLove, sex, and physical intimacy are some of the most desired goods in life and they are increasingly being sought on dating apps such as Tinder, Bumble, and Badoo. For those who want a leg up in the chase for other people’s attention, almost all of these apps now offer the option of paying a fee to boost one’s visibility for a certain amount of time, which may range from 30 min to a few hours. In this article, I argue that there are strong moral grounds and, in countries with laws against unconscionable contracts, legal ones for thinking that the sale of such visibility boosts should be regulated, if not banned altogether. To do so, I raise two objections against their unfettered sale, namely that it exploits the impaired autonomy of certain users and that it creates socio-economic injustices.
Selective Localization of Nanoparticles to Enhance the Properties of PBS/PLA Nanocomposite Blown Films
Authors: Garofalo Emilia , Di Maio Luciano , Scarfato Paola , Russo Paola , Incarnato Loredana 
Published: May 2023

AbstractThe addition of nanoparticles could allow to upgrade the performances of biopolymers, making them fit to replace petroleum-based plastics. In order to maximize the sustainability benefits of bio-nanocomposites, it is fundamental to opportunely tune their bulk properties by acting on their nanostructure. In particular, in nanocomposite blends the final morphologies are highly dependent on the selective localization of the nanoparticles: mainly inside one of the polymeric phases and/or at the interface.In this work, nanocomposite PBS (polybutylene succinate)/PLA (polylactic acid) blown films were prepared with the aim of optimizing their mechanical and gas barrier properties by profiting from the multiple functions of nanofillers as reinforcements, compatibilizers and morphology-directors. PBS/PLA blends, at a constant polymers’ weight proportion (80/20), were prepared by twin-screw extrusion, adding a constant amount of a lamellar nanosilicate (Cloisite 30B), according to different mixing routes: (i) by first dispersing the nanofillers inside the PLA or PBS phase, followed by the compounding with the other resin; (ii) by direct mixing of all the three components.The nanocomposite systems showed a finer dispersion of the PLA phase compared to the neat PBS/PLA blend. While a good exfoliation degree of the nanosilicate was generally observed for all the hybrid samples, the different blending sequence of the nanofillers significantly affected their preferential localization. In particular, the barrier and mechanical performances of the hybrid film PBS/(PLA + C30B) were most positively affected by the selective localization of the nanoplatelets at PBS/PLA interface, since their compatibilizing action was effectively exploited. In fact, this latter sample exhibited an interesting increase (+ 29%) of the deformation at break and a significant improvement (+ 33%) of the oxygen barrier compared with the neat PBS/PLA blend.
A Call for Rethinking International Arbitration: A TWAIL Perspective on Transnationality and Epistemic Community
Authors: Vesali Mahmoud Mansour , Sheikhattar Hosna 
Published: May 2023

AbstractDespite the increasingly diversified discourses in international commercial arbitration, this device of socio-legal regulation remains a relatively under-theorized subject. In particular, far too little attention has been paid to analyzing international commercial arbitration through critical approaches such as Third World Approaches to International Law (TWAIL). TWAIL is broadly understood as a methodological reorientation in international law by highlighting the historical links between the foundations of this field of law and the history of capitalism and imperialism as well as the colonial and Eurocentric legacies in the structure and operation of the current international legal regime. With this in mind, two fronts in international commercial arbitration invite a reexamination through a TWAIL perspective and by drawing on the concept of hegemony. One front is the transnational account of arbitration, and the other one is the epistemic community of arbitration. By examining these two notions through a narrative of hegemony of Western legal traditions, we posit that any effective attempt at redefining or reforming arbitral governance structure towards sustaining diversity requires a deeper understanding of historical and current world power structures and creating a vision for the prospect of dehegemonization.
Individualised prescription of medications for treatment of obesity in adults
Authors: Hocking Samantha , Sumithran Priya 
Published: May 2023

AbstractObesity continues to increase in prevalence globally, driven by changes in environmental factors which have accelerated the development of obesity in individuals with an underlying predisposition to weight gain. The adverse health effects and increased risk for chronic disease associated with obesity are ameliorated by weight loss, with greater benefits from larger amounts of weight reduction. Obesity is a heterogeneous condition, with the drivers, phenotype and complications differing substantially between individuals. This raises the question of whether treatments for obesity, specifically pharmacotherapy, can be targeted based on individual characteristics. This review examines the rationale and the clinical data evaluating this strategy in adults. Individualised prescribing of obesity medication has been successful in rare cases of monogenic obesity where medications have been developed to target dysfunctions in leptin/melanocortin signalling pathways but has been unsuccessful in polygenic obesity due to a lack of understanding of how the gene variants associated with body mass index affect phenotype. At present, the only factor consistently associated with longer-term efficacy of obesity pharmacotherapy is early weight loss outcome, which cannot inform choice of therapy at the time of medication initiation. The concept of matching a therapy for obesity to the characteristics of the individual is appealing but as yet unproven in randomised clinical trials. With increasing technology allowing deeper phenotyping of individuals, increased sophistication in the analysis of big data and the emergence of new treatments, it is possible that precision medicine for obesity will eventuate. For now, a personalised approach that takes into account the person’s context, preferences, comorbidities and contraindications is recommended.
Systematic reappraisal of marsh-orchids native to Scotland
Authors: Bateman Richard M. , Denholm Ian , McLeod Lindsey , Craig William , Ennos Richard A. 
Published: May 2023

SummaryThe intensively studied Eurasian orchid genus Dactylorhiza has become a model system for exploring allopolyploid evolution, yet determining the optimal circumscriptions of, and most appropriate ranks for, its constituent taxa remain highly controversial topics. Here, novel allozyme data and detailed morphometric data for 16 Scottish marsh-orchid populations are interpreted in the context of recent DNA sequencing studies. Despite being derived from the same pair of parental species, the two allopolyploid species that currently occur in Scotland can reliably be distinguished using allozymes, haplotypes, ribotypes or sequences of nuclear genes. A modest range of diverse morphological characters are shown to distinguish the two molecularly-circumscribed species, but they have in the past been obscured by equivalent levels of infraspecific variation in characters rooted in anthocyanin pigments; these characters are better employed for distinguishing infraspecific taxa. Dactylorhiza francis-drucei (formerly D. traunsteinerioides) is confirmed as being distinct from the continental D. traunsteineri/lapponica, probably originating through allopatric isolation once the continental lineage reached Britain. All Scottish populations are attributed to the comparatively small-flowered, anthocyanin-rich subsp. francis-drucei, which includes as a variety the former D. 'ebudensis'; the less anthocyanin-rich subsp. traunsteinerioides is confined to Ireland, North Wales and northern England. In contrast with D. francis-drucei, only a minority of Scottish populations of D. purpurella are attributed to the anthocyanin-rich race, var. cambrensis. This species most likely originated through an allopolyploidy event that occurred comparatively recently within the British Isles, as it contains allozyme alleles distinctive of British rather than continental D. incarnata (its diploid pollen-parent). In contrast, the rare Scottish population of D. incarnata subsp. cruenta shares with its Irish counterparts a continental genotype, and is most likely a recent arrival in Scotland through long-distance dispersal. Among all European allotetraploid dactylorchids, D. purpurella is the species that most closely resembles D. incarnata, both molecularly and morphologically.
KLF11 is an independent negative prognostic factor for breast cancer from a cohort study and induces proliferation and inhibits apoptosis in vitro
Authors: Lin Lili , Pfender Kristina , Ditsch Nina , Kuhn Christina , Rahmeh Martina , Peng Lin , Schmoeckel Elisa , Mayr Doris , Trillsch Fabian , Mahner Sven , Kessler Mirjana , Jeschke Udo , Hester Anna 
Published: May 2023

Abstract
Background
The therapy concepts that target several members of krüppel like factor (KLF) family have been achieved in breast cancer (BC). However, the role of KLF11 in BC remains unclear. This study explored the prognostic significance of KLF11 in BC patients and investigated its functional roles in this malignancy.

Methods
Immunohistochemistry (IHC) staining of KLF11 in 298 patients’ samples was performed to determine the prognostic role of the KLF11. Then the protein level was correlated to clinicopathological characteristics and survival outcomes. Afterward, the function of KLF11 was explored in vitro with siRNA-mediated loss-of-function of cell viability, proliferation, and apoptosis.

Results
From the cohort study, we found that the expression of KLF11 was positively associated with highly proliferative BC of BC. Furthermore, prognostic analysis demonstrated that KLF11 was an independent negative factor for disease-free survival (DFS) and distant-metastasis-free survival (DMFS) of BC. The KLF11-related prognostic model for DFS and DMFS showed high accuracy in predicting the 3-,5- and 10 -year survival probability of BC patients. Additionally, the knockdown of KLF11 inhibited cell viability and proliferation, as well as induced cell apoptosis in MCF7 and MDA-MB-231 cells, while only inhibited cell viability and induced cell apoptosis in SK-BR-3 cells.

Conclusions
Our study indicated that targeting KLF11 is an interesting therapeutic concept and further research could lead to a new therapeutic improvement in BC, especially in highly aggressive molecular subtypes.
DIOPHANTINE EQUATIONS OF THE FORM OVER FUNCTION FIELDS
Authors: RAY ANWESH 
Published: May 2023

AbstractLet
$\ell $
and p be (not necessarily distinct) prime numbers and F be a global function field of characteristic
$\ell $
with field of constants
$\kappa $
. Assume that there exists a prime
$P_\infty $
of F which has degree
$1$
and let
$\mathcal {O}_F$
be the subring of F consisting of functions with no poles away from
$P_\infty $
. Let
$f(X)$
be a polynomial in X with coefficients in
$\kappa $
. We study solutions to Diophantine equations of the form
$Y^{n}=f(X)$
which lie in
$\mathcal {O}_F$
and, in particular, show that if m and
$f(X)$
satisfy additional conditions, then there are no nonconstant solutions. The results apply to the study of solutions to
$Y^{n}=f(X)$
in certain rings of integers in
$\mathbb {Z}_{p}$
-extensions of F known as constant
$\mathbb {Z}_p$
-extensions. We prove similar results for solutions in the polynomial ring
$K[T_1, \ldots , T_r]$
, where K is any field of characteristic
$\ell $
, showing that the only solutions must lie in K. We apply our methods to study solutions of Diophantine equations of the form
$Y^n=\sum _{i=1}^d (X+ir)^m$
, where
$m,n, d\geq 2$
are integers.
How to Change Your Mind: The Contemplative Practices of Philosophy
Authors: Kalmanson Leah 
Published: May 2023

AbstractThe methods of philosophy may be associated with practices such as rational dialogue, logical analysis, argumentation, and intellectual inquiry. However, many philosophical traditions in Asia, as well as in the ancient Greek world, consider an array of embodied contemplative practices as central to the work of philosophy and as philosophical methods in themselves. Here we will survey a few such practices, including those of the ancient Greeks as well as examples from East Asian traditions. Revisiting the contemplative practices of philosophy can help us to rethink the boundaries of the discipline, the nature and scope of scholarly methods, and the role of philosophy in everyday life.
Grammars of Listening: Or On the Difficulty of Rendering Trauma Audible
Authors: Acosta López María del Rosario 
Published: May 2023

AbstractWhat would it mean to do justice to testimonies of traumatic experience? That is, how can experiences which do not fit the customary scripts of sense-making be heard? Whereas processes of official memorialization or legal redress often demand that victims and survivors convey their experiences through familiar modes of narration, in my project on ‘grammars of listening’ or ‘gramáticas de lo inaudito’ I want to ask how it might be possible to hear these experiences on their own terms and what the challenges are that we encounter when trying to do so. What I ultimately want to argue is that doing justice to trauma requires a profound philosophical questioning of the conditions that allow us to listen to testimony, and a true reckoning of the responsibility that we bear as listeners.
Fernando Pessoa: The Poet as Philosopher
Authors: Ganeri Jonardon 
Published: May 2023

AbstractFernando Pessoa (1888–1935) lived what was in many ways an astonishingly modern, transcultural, and translingual life. He was born in Lisbon, the point of departure for Vasco da Gama's voyage to India as commemorated by Pessoa's forebear, the poet Luís de Camões. Pessoa grew up in Anglophone Durban, acquiring a lifelong love for English poetry and language. Returning to Lisbon, from where he would never again leave, he set himself the goal of travelling throughout an infinitude of inner landscapes, to be an explorer of inner worlds. He published very little, but left behind a famous trunk containing a treasure trove of scraps, on which were written some of the greatest literary works of the twentieth century, mainly in Portuguese but also a substantial amount in English and French. Pessoa is now acknowledged as one of the greatest poets of the twentieth century, and he has emerged over the last decade as a forgotten voice in twentieth-century modernism, taking his rightful place alongside C.P. Cavafy, Franz Kafka, T.S. Eliot, James Joyce, and Jorge Luis Borges. Pessoa was also a serious student of philosophy and himself a very creative philosopher, yet his genius as a philosopher has as yet hardly been recognized at all.