bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dependence of learning outcomes in flipped and lecture classrooms on review questions: A randomized controlled trial and observational study
Authors: Pitt Jason , Huebner Bethany 
Published: December 2022

Purpose
The effects of class structure (i.e., lecture vs. flipped) and repeated review on: 1) exam scores and 2) student perceptions of learning were compared in a prospective randomized controlled trial (Study 1) and a retrospective cohort study (Study 2).

Methods
In Study 1, 42 second year students in a Doctor of Physical Therapy program were randomized to either a lecture or flipped section of a neurobiology class. Both sections incorporated repeated review. In Study 2, exam scores were retrospectively compared between two cohorts: a lecture cohort without repeated review (n = 42) and a flipped cohort with repeated review (n = 46). In both studies, outcomes of interest were exam scores and student surveys.

Results
In Study 1, students in the lecture and flipped sections had similar exam averages (lecture = 76.7 ± 17%, flipped = 77.5 ± 17%, p = 0.73). Repeated review significantly improved exam scores by 12.0 percentage points (95% CI: 8.0 to 16.0 percentage points) in the lecture section and 10.8 percentage points (95% CI: 6.9 to 14.8 percentage points) in the flipped section. The flipped section reported higher levels of satisfaction and perceived learning. In Study 2, the flipped cohort had significantly higher exam scores than the lecture cohort (lecture = 70.2 ± 6.9%, flipped = 83.4 ± 7.7%, p < 0.0001). Student satisfaction and perceived learning were similar in both cohorts.

Conclusion
Exam scores improve with review questions and quizzes provided in a class, both in a lecture or flipped classroom.
The association between social factors and COVID-19 protective behaviors and depression and stress among midwestern US college students
Authors: Garcia Colato Edlin , Ludema Christina , Rosenberg Molly , Kianersi Sina , Luetke Maya , Chen Chen , Macy Jonathan T. 
Published: December 2022

PurposeThe aim of this cross-sectional study was to examine the relationship between social factors and COVID-19 protective behaviors and two outcomes: depressive and perceived stress symptoms.MethodsIn September 2020, 1,064 randomly selected undergraduate students from a large midwestern university completed an online survey and provided information on demographics, social activities, COVID-19 protective behaviors (i.e., avoiding social events and staying home from work and school), and mental health symptoms. Mental health symptoms were measured using the Center for Epidemiological Studies Depression-10 questionnaire for depression and the Perceived Stress Scale-10 for stress symptoms.ResultsThe results showed respondents who were males and also the respondents who were “hanging out” with more people while drinking alcohol reported significantly lower depressive symptoms and lower stress symptoms. On the contrary, staying home from work or school “very often” was associated with higher stress symptoms, compared with “never/rarely” staying home from work/school. Similarly, having a job with in-person interaction was also associated with increased stress.ConclusionsThese findings suggest that lack of social engagement was associated with depression and stress symptoms among college students during the COVID-19 pandemic. Planning social activities that align with recommended safety precautions, as well as meet students’ social needs, should be an important priority for higher education institutions.
Reflections on contributing to health research: A qualitative interview study with research participants and patient advisors
Authors: Newington Lisa , Alexander Caroline M. , Kirby Pippa , Saggu Rhia K. , Wells Mary 
Published: December 2022

ObjectivesThe aims of this study were to explore individuals’ experiences of contributing to health research and to identify the types of impact that are perceived as important by participants or patient and public advisors. Specifically, research led by NMAHPP clinicians (Nursing, Midwifery, Allied health professions, Healthcare science, Psychology and Pharmacy).MethodsSemi-structured one-to-one interviews were conducted with health research participants and patient or public advisors. Interviewees were recruited from five UK sites and via social media. Interview transcripts were analysed using Thematic Analysis to identify key themes and areas of disagreement.ResultsTwenty-one interviews were completed, and four main themes were identified. The first, optimising research experiences, included personal reflections and broader recommendations to improve participant experiences. The second, connecting health research with healthcare, described research as key for the continued development of healthcare, but illustrated that communication between research teams, participants, and clinicians could be improved. The third theme explored the personal impacts of contributing to research, with interviewees recalling common positive experiences. The final theme discussed capturing research impacts. Interviewees highlighted potential priorities for different stakeholders, but emphasised that financial impacts should not be the sole factor.ConclusionIndividuals who were involved in NMAHPP health research recalled positive experiences and reported good relationships with their research teams. They felt that their contributions were valued. Suggested strategies to optimise the research experience focused on simplifying documentation, clear signposting of the research activities involved, and feedback on the research findings. Routine sharing of relevant research data with clinicians was also recommended. Personal impacts included a deeper understanding of their health condition or health more broadly, and increased confidence interacting with healthcare and other professionals. These findings will be used to inform development of a framework to capture the impact of NMAHPP research.
Predictors of biologic disease modifying antirheumatic drugs withdrawal due to the development of adverse events in patients with rheumatoid arthritis
Authors: Koltsova E. N. , Lukina G. V. , Schmidt E. I. , Lytkina K. A. , Zhilyaev E. V. 
Published: December 2022

Currently, a large number of highly effective biologic disease modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) are used for the treatment of rheumatoid arthritis (RA). However, in addition to effectiveness, it is necessary to evaluate the risk of adverse events (AEs) when using them.Objective: to determine the predictors of bDMARDs and tsDMARDs discontinuation due to AEs in patients with RA.Patients and methods. The study included 661 patients with RA who took bDMARDs and tsDMARDs. The search for predictors of targeted therapy discontinuation due to AEs was carried out in two stages. At the first stage, using the Kaplan-Meier method, we selected indicators that showed the greatest significant single-factor relationship with the duration of retention on therapy. At the second stage, significant independent indicators were obtained by iterative selection of variables within the multivariate proportional risk model according to Cox.Results and discussion. The presence of rheumatoid nodules (p<0.001), high doses of glucocorticoids (GC; p<0.001), low doses of methotrexate (MT; p=0.009) are significant independent factors for increasing the risk of drugs discontinuation due to the development of AEs. The type of bDMARDs/tsDMARD used also significantly correlated with the risk of discontinuation of therapy due to AEs. A relatively high risk of treatment discontinuation was observed with infliximab (IFN) and certolizumab pegol (CZP). Cancellation of IFN was associated with the occurrence of infusion reactions and infectious complications, and CZP was associated with infectious complications.Conclusion. An increase in the dose of MT and decrease in the use of GCs can help prevent the development of AEs leading to the abolition of biologics and tsDMARDs. Significant differences were found between bDMARDs in terms of the risk of their cancellation due to AEs.
Retention on tofacitinib therapy in patients with rheumatoid arthritis (real clinical practice data)
Authors: Gridneva G. I. , Aronova E. S. , Belov B. S. 
Published: December 2022

Evaluation of the reasons for discontinuation of therapy with Janus kinase inhibitors (JAKi) may provide a clue to their more effective use.Objective : to analyze the survival of tofacitinib (TOFA) therapy and the reasons for its discontinuation in rheumatoid arthritis (RA) in real clinical practice.Patients and methods. The study included 30 adult patients with RA hospitalized to the V.A. Nasonova Research Institute of Rheumatology from 2018 to 2020 for the biologic disease modifying antirheumatic drugs (bDMARDs) or JAKi treatment. Patients were followed up for 3 years or until treatment with TOFA was discontinued, whichever occurred first.Results and discussion. TOFA was prescribed as the first line therapy in 3 patients. In all these patients, the drug was discontinued for the following reasons: insufficient efficacy (IE) after 2 full years of treatment; adverse reaction (AR); administrative reasons (AdR), i.e. the inability to continue therapy due to the lack of drug supply at the place of residence. 11 patients received TOFA as the second line therapy, in 8 of them the treatment was interrupted: in 4 due to IE, in 3 due to AR (skin allergy) and in 1 due to AdR one year after its initiation. TOFA was prescribed as a third line therapy in 9 patients, in 2 of them the drug was discontinued due to IE and in 3 due to AR (allergic dermatitis in 2, dyspepsia in 1). Another 1 patient refused treatment due to a planned pregnancy. 6 patients received TOFA as the fourth line therapy, 5 of them (83.3%) continued to receive it for more than 3 years. In 1 patient, TOFA was discontinued after 1 month due to the dry cough and shortness of breath onset. In another 1 patient who was prescribed TOFA as the fifth line therapy, treatment was discontinued due to AR (recurrent Herpes zoster).Conclusion. As the results of the study show, no relationship was found between the incidence of AR or IE and clinical and demographic indicators, as well as the frequency of TOFA withdrawal and the line of therapy. At the same time, the shortest duration of retention on TOFA therapy was noted when it was prescribed as a first-line drug.
Complex treatment of patellofemoral pain syndrome in athletes after reconstruction of the anterior cruciate ligament of the knee joint
Authors: Arkov V. V. , Dmitriev A. A. , Milenin O. N. , Ordzhonikidze Z. G. , Sichinava N. V. , Badtieva V. A. , Alekseeva L. I. , Lila A. M. 
Published: December 2022

Patellofemoral pain syndrome (PFPS, patellar chondromalacia) after knee surgery is an important problem in sports medicine, solutions to which have not been developed enough.Objective: to determine the effect of complex treatment using an injectable chondroprotector and special exercise therapy on the functional state, statokinetic stability and severity of PFPS in athletes after reconstruction of the anterior cruciate ligament (ACL) of the knee joint.Patients and methods. An observational randomized controlled trial included 40 athletes after ACL reconstruction. The patients were divided into two groups. In the control group (n=20), a special rehabilitation technique was used after ACL reconstruction. In the main group (n=20), along with a similar method of rehabilitation, patients received a course of intramuscular injections of Alflutop (1 ml, No. 20). The duration of rehabilitation treatment was 1 month.Pain was assessed using a numerical rating scale and knee joint function using the Kujala questionnaire, statokinetic stability was assessed before and after complex rehabilitation treatment.Results and discussion. One month after the start of rehabilitation measures, both groups showed a significant decrease in pain intensity and an improvement in the functional state of the knee joint according to the Kujala questionnaire. The study of statokinetic stability indicators showed that after the course of rehabilitation in both groups, when standing with open eyes, there was a decrease in the area of the common center of pressure — CCOP (p<0.05) and an improvement in statokinetic stability, and when standing with eyes closed, a decrease in the CCOP area (p<0.05). At the same time, the difference in the results before and after the course of rehabilitation in the main group was significantly greater than in the control (p<0.05). The speed of the CCOP movement with open eyes in both groups did not change significantly: when standing with eyes closed, its positive dynamics was revealed after the course of rehabilitation (p<0.05).Conclusion. Intramuscular SYSADOA injection therapy, which was used as part of a rehabilitation program, reduced pain and improved the function of the knee joint and had a positive effect on statokinetic stability in athletes after ACL reconstruction.
Interleukin 6 receptor inhibitors in the treatment of rheumatoid arthritis during the COVID-19 pandemic, Moscow experience
Authors: Zagrebneva A. I. , Simonova E. N. , Mezenova T. V. , Burmistrova N. B. , Gavrikova Yu. A. , Gavrikova Yu. A. , Morozova E. O. , Kodzeva Zh. M. , Sapogina K. S. 
Published: December 2022

Objective: to confirm the efficacy and safety of levilimab in patients with rheumatoid arthritis (RA) switched from other interleukin 6 receptor inhibitors (iIL6R) for non-medical reasons.Patients and methods. A retrospective analysis of data from the register of patients with RA who during the COVID-19 pandemic were switched from foreign iIL6Rs to the Russian drug levilimab. Treatment regimens with levilimab in combination with synthetic diseasemodifying antirheumatic drugs (sDMARDs) and/or glucocorticoids (GCs) were used, as well as a monotherapy regimen in case of DMARDs intolerance.Results and discussion. In 150 patients with RA, a successful non-medical switch to levilimab was demonstrated with the preservation and intensification of the clinical effect achieved on previous therapy with iIL6R. After switching to levilimab, the DAS28-CRP index decreased by an average of 0.098 at 3 months and by 0.25 at 6 months (p=0.214 for both time points). There was a decrease in the proportion of patients with elevated levels of CRP, as well as with high RA activity. In a number of patients who showed high efficacy of levilimab, it became possible to reduce the dose or number of DMARDs, as well as cease GCs intake. Good tolerability and a favorable safety profile of levilimab were noted, including in relation to the new coronavirus infection that developed during therapy.Conclusion. Therapy with Russian iIL6R levilimab is effective and safe, including in patients switched from other drugs for non-medical reasons, as well as in relation to the novel coronavirus infection that developed during therapy.
Development of bilateral episcleritis and rheumatoid arthritis after a new coronavirus infection: a description of a clinical case
Authors: Matveeva O. N. , Kvasova E. V. 
Published: December 2022

In December 2019, the world faced a new infectious disease, called the novel coronavirus disease 2019 (COVID-19), whose spread has become pandemic. The infection that remains with us to the present day can cause very severe respiratory symptoms up to total lung damage and death, as well as serious systemic manifestations associated with excessive activation of immune mechanisms. Currently, there are many cases of secondary autoimmune processes, often forming full-fledged autoimmune diseases, in people who have had a new coronavirus infection.We present a clinical observation of episcleritis developed on the background of COVID-19, and then an articular syndrome onset that met the classification criteria for rheumatoid arthritis. The unusual debut of the articular syndrome in this patient, the difficulties of early diagnosis of the disease, as well as possible mechanisms of the formation of such associations are discussed.
Major-Occupation Match Quality: An Empirical Measure Based on Relative Productivity
Authors: Leighton Margaret , Speer Jamin D. 
Published: December 2022

Abstract
The match quality between a worker’s field of study in college and her occupation is an important labor market outcome. Yet this match quality is difficult to define and measure. We propose a new measure of major-occupation match quality based on relative productivity. A worker is well-matched if graduates from her major, working in her occupation, have high earnings relative to other major-occupation pairs. We show that some majors can be very well-matched or very badly matched (e.g. nursing), while others are never very well- or badly matched (e.g. humanities). Our measure has two desirable features: it is continuous, and it can be estimated in any data set including field of study, wage, and occupation.
Returning a maverick creole to the fold: the Berbice Dutch enigma revisited
Authors: Parkvall Mikael , Jacobs Bart 
Published: December 2022

AbstractBerbice Dutch was a creole language spoken in the Republic of Guyana in South America, a country first under Dutch, and later under British colonial rule. Owing mainly to Silvia Kouwenberg (A grammar of Berbice Dutch Creole, De Gruyter Mouton, 1994), we were blessed with a detailed synchronic documentation of Berbice Dutch before its demise. However, the formation of the language remains clouded in mystery: its grammar and (basic) lexicon display a seemingly unique mixture of Dutch (Creole) and Eastern Ijo, as a result of which the language is often portrayed as a challenge to existing contact-linguistic theory. In this paper, a scenario is proposed that, rather than challenging the said theory, is fully grounded in it: it will be argued that the language was a case of serial glottogenesis: a first stage of creolisation was later followed by language mixing. The paper furthermore presents hitherto unknown historical data pertaining to the arrival of Ijo speakers in Berbice.
Accelerated weathering performance of plantation-grown juvenile poplar and Chinese fir woods
Authors: Yu Yang , Xiao Zefang , Liang Daxin , Wang Yonggui , Militz Holger , Xie Yanjun 
Published: December 2022

Abstract
Plantation-grown juvenile wood species are extensively used as raw materials in the Chinese wood industry. The weathering performances of the wood are crucial for outdoor application. Two of the most important plantation-grown juvenile woods, poplar (Populus × euramericana cv. ‘74/76ʼ) and Chinese fir (Cunninghamia lanceolata Hook), were sliced into thin veneers and compared in this study to observe their weathering performance during exposure to UV alone for 504 h and UV/water for 168 h. The color difference, weight loss, and tensile strength loss of both veneers all increased with exposure time. Scanning electron microscopy showed that the initial structural deterioration originates from the corner of the middle lamella and pit, followed by cell separation, cell wall thinning, deformation, and collapse. Fourier transmission infrared spectroscopy, electron resonance spectrometry and X-ray photoelectron spectroscopy revealed a decrease in lignin-based infrared absorption intensity and radical generation, as well as an increase in O/C ratio throughout the exposure. Water spray considerably accelerated deterioration by washing away the degraded fragments, thereby exposing the fresh substrate underneath. Compared to poplar wood, Chinese fir showed durable structural integrity but more darkening during weathering. These findings reveal the anatomically structural weak phase and photo-degradation performance of two plantation-grown woods during weathering. The results of this work may facilitate the proper external use and further photo-stabilization treatment of plantation-grown juvenile wood products.
Experimental investigation on microstructural characterization and mechanical properties of plasma arc welded Inconel 617 plates
Authors: Srinivas Kadivendi , Vundavilli Pandu R. , Manzoor Hussain M. 
Published: December 2022

Abstract
Welding of Inconel is a difficult task due to its tendency to crack and posing intricacies to the welder. However, it is extensively used in applications where resistance to oxidation at elevated temperatures is required. Therefore, it is important to note that the welding of Inconel alloys is demanding. Under such circumstances, one has to automate the welding of Inconel 617 alloy to eliminate some of the process uncertainties. Plasma arc welding (PAW) is a highly non-linear process that can be automated easily, and it can provide more focussed arc to weld the high strength and creep-resistant alloys. In the present research, PAW process is employed on 2 mm thick Inconel 617 plates by varying the key process parameters, such as welding current and welding speed. Initially, bead on plate (BoP) experiments were conducted to determine the suitable range of welding parameters to weld the super alloy. Subsequently, butt welding of the plates was performed based on the results of BoP welding. Furthermore, a study was conducted to determine the influence of the welding process parameters on the microstructural and mechanical properties of the butt joints.
Cross electromagnetic nanofluid flow examination with infinite shear rate viscosity and melting heat through Skan-Falkner wedge
Authors: Tag El Din El Sayed M. , Sajid Tanveer , Jamshed Wasim , Shah Syed Zahir Hussain , Eid Mohamed R. , Ayub Assad , Guedri Kamel , Sánchez-Chero Manuel , Chero José Antonio Sánchez , Barco Gilberto Carrión , Maquen-Niño Gisella Luisa Elena 
Published: December 2022

Abstract
This demonstration of study focalizes the melting transport and inclined magnetizing effect of cross fluid with infinite shear rate viscosity along the Skan-Falkner wedge. Transport of energy analysis is brought through the melting process and velocity distribution is numerically achieved under the influence of the inclined magnetic dipole effect. Moreover, this study brings out the numerical effect of the process of thermophoresis diffusion and Brownian motion. The infinite shear rate of viscosity model of cross fluid reveals the set of partial differential equations (PDEs). Similarity transformation of variables converts the PDEs system into nonlinear ordinary differential equations (ODEs). Furthermore, a numerical bvp4c process is imposed on these resultant ODEs for the pursuit of a numerical solution. From the debate, it is concluded that melting process cases boost the velocity of fluid and velocity ratio parameter. The augmentation of the minimum value of energy needed to activate or energize the molecules or atoms to activate the chemical reaction boosts the concentricity.