bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum Dot Transition Rate Modifying by Coupling to Lattice Plasmon
Authors: HATEM *sude , Salmanogli Ahmad , Gecim H. Selcuk 
Published: February 2023

Abstract
In this study, a plasmonic system coupled to a quantum dot is defined to generate the entanglement between two non-simultaneous emitted output modes. The quantum dot with three energy levels creates two different transition rates by which non-simultaneous photons are emitted. Thus, it seems that the entanglement between two emitted modes is forbidden. However, the simulation results show the entanglement between the output modes. It is because the original transition rates of the quantum dot are modified due to the lattice plasmon coupling effect. It means that the effective transition rate affected by the lattice plasmon plays the key role. The lattice plasmon coupling to quantum dot at some locations leads to a simultaneous transition by which the entanglement between output modes is established. This unique behavior is theoretically discussed and the results shows that using lattice plasmon can change the transition rates by which the two emitted modes become entangled.
Benzothiadiazole-based rotation and possible antipolar order in carboxylate-based metal-organic frameworks
Authors: Schnabel Jennifer , Schulz Arthur , Lunkenheimer Peter , Volkmer Dirk 
Published: February 2023

Abstract
By modifying organic ligands of metal-organic framework with dipolar units, they turn suitable for various applications, e.g., in the field of sensor systems or switching of gas permeation. Dipolar linkers in the organic ligand are capable to rotate in certain temperature and frequency ranges. The copper-bearing paddlewheel shaped metal organic frameworks ZJNU-40 and JLU-LIU-30 possess such a polarizable dipole moment due to their benzothiadiazole moiety in the organic ligands. Here, we investigate the molecular rotor behaviour of benzothiadiazole units of the two carboxylate-based MOFs by dielectric spectroscopy and computational simulation. Our dielectric results provide clear evidence for significant reorientational relaxation dynamics of these rotors, revealing various characteristics of glasslike freezing upon cooling. The calculated rotational energy barriers are consistent with experimentally determined barriers for single-dipole dynamics. Moreover, for JLU-LIU-30 we find hints at antipolar ordering below about 300 K.
Inhibitory Effect of Recombinant Tyrosine-sulfated Madanin-1, a Thrombin Inhibitor, on the behavior of MDA-MB-231 and SKOV3 Cells in vitro
Authors: Jo Guk Heui , Jung Sun Ah , Roh Tae Hoon , Yoon Jin Sook , Lee Joon H. 
Published: February 2023

Abstract

Thrombin, which plays a crucial role in hemostasis, is also implicated in cancer progression. We investigated the effects of the thrombin-targeting recombinant tyrosine-sulfated madanin-1 on cancer cell behavior and signaling pathways compared with wild-type (WT) madanin-1. We generated recombinant madanin-1 2 sulfation (2S) and madanin-1 WT proteins using E. coli. SKOV3 and MDA-MB-231 cells were treated with purified recombinant proteins with or without thrombin stimulation. Migration and invasion of cells were analyzed by a wound healing assay and transwell assay, respectively. Thrombin markedly increased cell migration and invasion in both SKOV3 and MDA-MB-231 cells, which were significantly suppressed by madanin-1 2S (p < 0.05). Madanin-1 2S also significantly suppressed thrombin-induced expression of phosphorylated Akt and extracellular signal-regulated kinase (ERK) in both cell lines (p < 0.05), but not by madanin-1 WT in MDA-MB-231 cells. Furthermore, madanin-1 2S significantly reversed the expression of E/N-cadherin and vimentin in thrombin-treated MDA-MB-231 cells (p < 0.05), whereas madanin-1 WT did not show any effect. In conclusion, madanin-1 2S suppressed migration and invasion of cancer cells more effectively than madanin-1 WT. We postulate that inhibiting thrombin via the sulfated form of madanin-1 may be a potential candidate for enhanced cancer therapy, albeit further in vivo validation is required.
Strong mechanical squeezing in microcavity with double quantum wells
Authors: Asjad Muhammad , Teklu Berihu , Eleuch Hichem 
Published: February 2023

Abstract
We address the creation of squeezed states of a mechanical resonator in a hybrid quantum system consisting of two quantum wells placed inside a cavity with a moving end mirror pumped by bichromatic laser fields. The exciton mode and mechanical resonator interact indirectly via microcavity fields. Under the conditions of the generated coupling, we predict squeezing of the mechanical-mode beyond the resolved side-band regime with available experimental parameters. Finally, we show that the squeezing of the mechanical mode is robust against the phonon thermal bath temperature.
Targeting methylated regions using covariation and distance
Authors: Fenton Christopher G. , Meng Wei , Anderssen Endre , Ray Mithlesh K. , Paulssen Ruth H. 
Published: February 2023

Abstract
Background
The analysis of WGBS (whole genome bisulfite sequencing) datasets is challenging. The large number of CpG sites requires significant computing power and can lead to harsh multiple correction penalties. Typically, the number of CpG sites found in DMRs (differentially regulated regions) represent a very small proportion of the initial number of CpG sites. This is because methylation levels of the majority of CpG sites do not vary significantly between samples, and/or the CpG sites are too far dispersed to be considered a contiguous region. DMRs are like likely to be found in relatively compact CpG rich regions that vary in methylation levels. Isolating these regions could greatly reduce downstream computational and statistical challenges without any previous knowledge of sample groups.
Results
The proposed method was able to isolate compact CpG rich variable regions using distance, covariation, and user parameters without a priori sample information. Results were verified with EpiDISH cell deconvolution and comparable with to a complementary method DMRSeq. Isolated regions averaged just 293 bp in length yet contained an average of 29 CpG sites per region.
Conclusions
By defining compact CpG rich variable regions, the method hopes to provide a valid and simpler starting point for further downstream analyses. This method is applicable to any dataset containing total CpG and total CpG methylated count matrices.
DNA metabarcoding reveals the diet of the invasive fish Oreochromis mossambicus in mangroves of São Tomé Island (Gulf of Guinea).
Authors: Nogueira S. , Curto M. , Gkenas C. , Afonso F. , Dias D. , J. Heumüller , Félix P.M. , de Lima R.F. , Chaínho P. , Brito A.C. , Ribeiro F 
Published: February 2023

Abstract
Invasive species can trigger profound effects on recipient ecosystems, namely through the food web. Despite being recognized as one of the worst invasive species, little is known about the feeding ecology of the Mozambique tilapia (Oreochromis mossambicus). To understand how this invasive species might impact food webs, we applied metabarcoding to analyze its diet’s composition in two mangroves, in the Obô Natural Park in the oceanic island of São Tomé. Given the particular importance of mangroves as fish nurseries, we specifically aimed to determine if this invader might predate on other fish species. However, tilapias were mostly phytoplanktivorous, and there were few indications of predation on native fish eggs or larvae. Instead, tilapias may impact low trophic level resources and nutrient availability with the potential to cascade through the food web by means of bottom-up disruption. In addition, we recorded important changes in the taxonomic composition of the diet, linked to locations and life stages, suggesting that its opportunistic feeding associated with its aggressive territorial behavior may result in resource competition with native species with which it has overlapping dietary niches.
Alpha radiation from polymetallic nodules and potential health risks from deep sea mining
Authors: Volz Jessica , Geibert Walter , Köhler Dennis , Loeff Michiel Rutgers van der , Kasten Sabine 
Published: February 2023

Abstract
Polymetallic nodules at the abyssal seafloor are targeted for future mining operations. Nodules efficiently scavenge and retain several dissolved particlereactive uraniumseries radioisotopes, which predominantly emit alpha radiation during decay. Here, we present new data on the activity concentrations of the naturally occurring radioisotopes thorium-230, radium-226, and protactinium231, as well as on the release of radon-222 in and from nodules from the NE Pacific Ocean. Together with abundantly published data from historic studies, it becomes apparent that the radioisotopes in the nodules mostly exceed exempt activity levels. These exempt levels are in place for naturally occurring radioactive materials (NORM) such as uranium ore, where, due to the enhanced radiation exposure, handling these materials is regulated to protect the public and ensure occupational health. In comparison with these exempt levels, activity concentrations in the nodules are up to three orders of magnitude higher. Seen in this light, inappropriate handling and treatment of polymetallic nodules may pose health risks, particularly if large quantities are stored in enclosed spaces such as during mining operations at sea, and if nodule fines are inhaled during processing.
Adsorption Characteristics of Sulfonamide Antibiotic Molecules on Carbon Nanotube and the Effects of Environment
Authors: Wu Yang , Liu Sha-Sha , Huang Kai-Yue , Yang Qing-Hong , Zheng Yan , Li Lai-cai 
Published: February 2023

Abstract
In this paper, the adsorption characteristics of five sulfonamide antibiotic molecules on carbon nanotubes were investigated using density functional theory (DFT) calculations. The adsorption configurations of different adsorption sites were optimized, and the most stable adsorption configuration of each sulfonamide molecule was determined by adsorption energy comparison, and the relative adsorption stability of five sulfonamide molecules on carbon nanotubes was determined by comparing their adsorption energies i.e. sulfamethazine > sulfadiazine > sulfamerazine > sulfamethoxazole > sulfanilamide. The electron densities of the adsorption configurations were then calculated to confirm that the adsorption of five sulfonamide drug molecules on carbon nanotubes should be physical adsorption. Moreover, the adsorption energy of five sulfonamide molecules on carbon nanotubes in the aqueous environment was larger than that in vacuum even though the adsorption process remain to be physical adsorption. The adsorption characteristics of the five sulfonamide molecules in various acid-base environments were finally investigated. In contrast, the adsorption energies of the five drug molecules in acid-base environments were significantly reduced, indicating that carbon nanotubes may need to have a suitable pH range to achieve the optimal adsorption effect when they are used for the treatment of sulfonamide antibiotics.
Efficacy of lvpao powder on Radiotherapy-Induced Mucositis: A retrospective study of 11 4 patients with head and neck Carcinoma
Authors: Chen Liyao , Lu Fei , Qian Haihong , Wang Hua , Zhang Feiyue 
Published: February 2023

Abstract
Purpose: To compare the efficacy and safety of kangfuxin solution and lvpao powder on mucositis induced by radiotherapy in head and neck carcinoma patients.
Methods: We retrospectively analyzed 114 patients with head and neck malignant tumors in our center. Patients were given Kangfuxin solution to rinse the mouth or Lvpao powder group sprayed the powder on oral mucosa after the solution use. The side effect was evaluated by Common Terminology Criteria for Adverse Events, version 4.0.
Results: The grade 3 mucositis occurred in 32.9% (23/70) and 11.4% (5/44) in Kangfuxin solution group and kangfuxin solution plus lvpao powder group respectively(P=0.009). The pain score of the Kangfuxin solution group was significantly higher than that of the Kangfuxin solution and lvpao powder group with 4.26 ± 0.81 vs 3.75 ± 1.03(P=0.007). The time of symptom relief in the combined group was significantly shorter than that in the single drug group with 3 days vs 6 days (P=0.000). The weight loss of the former groups was bigger than that of the latter group(6.67 ± 1.20kg vs 5.95 ± 0.94kg, P=0.001). There was no statistical difference in the limitations in mouth opening(P=0.164).
Conclusion: Lvpao powder is safe and effective as a mucosal repair drug in accelerating the recovery of patients and reducing their body weight.
Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer’s disease
Authors: Verbeek Dineke , Hofstra Bente , Kas Martien 
Published: February 2023

Abstract
As there is growing evidence of shared pathogenesis between Alzheimer’s disease and depression, we aimed to further investigate the shared disease mechanisms of these highly comorbid disorders using brain-specific eQTL data and gene co-expression networks of genetic loci significantly associated with Alzheimer’s disease and depression. We found no identical GWAS SNPs between Alzheimer’s disease and depression, but brain-specific eQTL data uncovered six shared genes: SRA1, MICA, PCDHA-7, PCDHA-8, PCDHA-10 and PCDHA-13. To identify genes related to the shared eQTL genes, we obtained genes in co-expression with the eQTL genes, specifically in the hippocampus. Next, we performed pathway analysis on these disease-specific gene sets. Clustering of these pathways uncovered key roles for synaptic signaling and organization, myelination, development and the immune system in the hippocampus as shared pathology between Alzheimer’s disease and depression. With this study we show that the genetic underpinnings in both diseases affect pathways in the hippocampus that could work in tandem for the development of both Alzheimer’s disease and depression.
Leveraging the fintech model for climate sustainability: Scoping through a qualitative approach
Authors: G Sreelekshmi , V Biju A 
Published: February 2023

Abstract
Climate crisis has become a crucial concern for humankind as a result of which climate-sustainable development has become indispensable. This necessitates the sustainable adoption of innovative ideas and technologies. Against this backdrop, the fintech industry saw the emergence of a novel fintech model with a climate action motive, known as climate fintech or green fintech. We identify green fintech as a small, growing research area. Our research attempts to draw insights on the state of the art of the concept using an inductive qualitative methodology comprising a systematic review of existing studies, case research of Indian climate fintech, and sentiment analysis. India is one of the most active fintech markets in the world using domestic technologies like Unified Payment Interface (UPI), showing a fantastic growth trajectory in terms of international adoptions. Our analysis of the climate fintech landscape finds considerable scope for the climate fintech concept in attaining the country’s climate targets. We anticipate that the area and its applications will advance in the future, for which suggestions are proposed.
Anti-periodic Solutions Dynamics for Fractional-order Inertia Cohen-Grossberg Neural Networks
Authors: Xu danning , Jiang wangdong 
Published: February 2023

Abstract
The dynamic behavior of anti-periodic solutions for fractional-order inertia Cohen-Grossberg neural networks is investigated in the article. First, the fractional derivative with different orders is transformed to that with the same order by properly variable substitution; Second, a sufficient condition can ensure the solution is global Mittag-Leffler stability by using properties of fractional calculus and characteristics of Mittag-Leffler function; Moreover, a sufficient condition for the existence of an anti-periodic solution is given by constructing a system sequence solution that converges to a continuous function using Arzela-Asolitheorem. In the final, we verify the correctness of the conclusion by numerical simulation.
High-speed binary coded decimal digit multipliers with multiple error detection
Authors: Yazdanian-Amiri Zahra , Valinataj Mojtaba 
Published: February 2023

Abstract
Decimal arithmetic in the form of binary coded decimal (BCD) numbers is preferred in many financial and commercial applications. BCD multipliers are introduced as a key hardware unit to support both integer and floating-point decimal arithmetic operations. However, due to the increasing sensitivity of VLSI-based digital designs to the environmental effects, BCD multipliers are also prone to faults and errors similar to other arithmetic circuits. In addition, multiple error occurrence is possible in current digital systems which motivates to reach multiple error detection/correction in addition to single errors. In this paper, digit-by-digit BCD multipliers are introduced capable of multiple error detection with low delay overheads. To show the effectiveness of the proposed combined method, a 4-digit BCD multiplier is presented. Experimental results based on analysis and error injection-based simulations show that in addition to 100% single error detection, multiple errors can be detected with at least 99.6% probability in the 4-digit BCD multiplier as the implemented architecture.
Administration of high-dose estradiol and progesterone in hormone replacement therapy improves results of frozen-thawed embryo transfer in a patient with 21-hydroxylase deficiency and persistently high serum progesterone levels: a case report
Authors: Mizusawa Yuri , Enatsu Kunihiro , Yamada Ai , Hayashi Nao , Enatsu Yihsien , Okamoto Eri , Kokeguchi Shoji , Iwasaki Toshiro , Shiotani Masahide 
Published: February 2023

Abstract
Background
Women with 21-hydroxylase deficiency have reduced fertility because of excessive production of adrenal androgen and progesterone, which can inhibit folliculogenesis, disturb the normal gonadotropin secretion pattern and development of the endometrium, and affect endometrial receptivity. The use of high doses of estradiol and progesterone in frozen-thawed embryo transfer with hormone replacement therapy may improve the results of fertility treatment in women with 21-hydroxylase deficiency and high progesterone.
Case presentation:
A 40-year-old woman with 21-hydroxylase deficiency and persistently high progesterone levels who was receiving steroid treatment visited our institution because she wanted to have a second child. Previously, she had had difficulties with frozen-thawed embryo transfer because of a gradual increase in progesterone levels. After reduction of progesterone levels with steroid hormone treatment, she had succeeded having a healthy baby after frozen-thawed embryo transfer with hormone replacement therapy. She hoped to have a second child with the same method, but steroid hormone treatment did not decrease her progesterone level. Frozen-thawed embryo transfer with hormone replacement therapy was attempted despite the high progesterone level, but the patient had two miscarriages. In the third attempt, the patient was given a high dose of estradiol and progesterone medication, which led to a better result than with the first two attempts.
Conclusions
Administering a high dose of estradiol and progesterone medication during frozen-thawed embryo transfer with hormone replacement therapy might achieve better results in women with 21-hydroxylase deficiency and persistently high progesterone levels.
Clinical characteristics, prognosis, and surgical outcomes of patients with NBNC hepatocellular carcinoma: three-decade observational study
Authors: Yasukawa Koya , Shimizu Akira , Kubota Koji , Notake Tsuyoshi , Hosoda Kiyotaka , Hayashi Hikaru , Soejima Yuji 
Published: February 2023

Abstract
Background: The incidence of non-hepatitis B virus, non-hepatitis C virus hepatocellular carcinoma (NBNC-HCC) is increasing worldwide. We assessed the clinical characteristics and surgical outcomes of NBNC-HCC, versus hepatitis B (HBV-HCC) and hepatitis C (HCV-HCC).
Methods: Etiologies, fibrosis stages, and survival outcomes were analyzed of 789 consecutive patients who underwent surgery from 1990 to 2020 (HBV-HCC, n=149; HCV-HCC, n=424; NBNC-HCC, n=216).
Results:The incidence of hypertension and diabetes mellitus was significantly higher in patients with NBNC-HCC than in those with HBV-HCC and HCV-HCC. Significantly more advanced tumor stages were observed in patients with NBNC-HCC; however, better liver function and lower fibrosis stages were observed. Patients with NBNC-HCC had significantly worse 5-year overall survival than patients with HBV-HCC; overall survival was comparable between patients with NBNC-HCC and HCV-HCC. Patients with HCV-HCC had significantly worse 5-year recurrence-free survival than patients with HBV-HCC and NBNC-HCC. In patients with NBNC-HCC, overall survival was comparable among three periods (1990–2000, 2001–2010, and 2011–2020) despite significant improvement in patients with HBV-HCC and HCV-HCC.
Conclusion: The prognosis of NBNC-HCC was similar to that of HBV-HCC and HCV-HCC regardless of tumor progression at surgery. Patients with hypertension, diabetes mellitus, and dyslipidemia require careful systematic follow-up and treatment.
Visual Outcomes and Patient Satisfaction after Bilateral Implantation of an Enhanced Monofocal Intraocular Lens: A Single Blind Prospective Randomized Study
Authors: Giglio Rosa , Vinciguerra Alex Lucia , Presotto Marianna , Jonak Kamil , Rejdak Robert , Toro Mario Damiano , Tognetto Daniele 
Published: February 2023

Abstract
Purpose: To evaluate and compare the visual outcomes of an enhanced monofocal IOL with two different monofocal IOLs.
Setting: Eye Clinic, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Design: Prospective, single-centre, single-blind, randomized controlled clinical study.
Methods: The study included patients undergoing phacoemulsification and IOL implantation. Patients were consecutively randomized by block randomization and assigned in a 1:1:1 allocation ratio to three study arms to bilaterally receive Tecnis® Eyhance (model ICB00) or Tecnis®1-piece (model ZCB00) or Alcon®1-piece (model Clareon, CNA0T0) respectively. Monocular and binocular (both corrected and uncorrected) visual acuities for far, intermediate and near were registered and compared among groups. To track changes in patient quality of life, the Catquest-9SF questionnaire was administered to each patient before and after cataract extraction.
Results: A total of 90 patients (30 for each group) were enrolled. At 3 months follow-up, statistically significant differences for intermediate and near distance visual acuities were found between the three groups. Non-statistically significant differences were observed for distance visual acuities and the changes in Catquest-9SF scores.
Conclusion: Tecnis® Eyhance ICB00 IOL provided better results in intermediate visual outcomes without negative effects on patients’ quality of life.