bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in pediatric non‐operating room anesthesia: Data from the National Anesthesia Clinical Outcomes Registry
Authors: Louër Ryan , Szeto Mindy , Grasfield Rachel , McClain Craig D. , Urman Richard D. , Brovman Ethan Y. 
Published: February 2023

AbstractBackgroundModern pediatric anesthetic encounters occur in operating rooms and non‐operating room settings. Most anesthesia providers have cared for children in radiology, endoscopy, and other interventional settings at some point in their training and career. There is an absence of published data on the frequency, timing, and demographics of these pediatric anesthesia encounters.AimsThe primary goal of our study is to present data spanning a variety of institutions and practice settings in the United States to define the percentage of non‐operating room anesthetic encounters in children. We also set out to characterize the frequency of the most common procedures in the non‐operating room setting within the United States.MethodsUsing the National Anesthesia Clinical Outcomes Registry data from 2015–2019, we analyzed and reported data on current trends in non‐operating room anesthesia including patient demographics, encounter setting, procedure type, and the time at which anesthetic encounters occurred.Results2 236 788 pediatric anesthetic encounters (patient age <18 y.o.) were analyzed revealing that 22.7% of all pediatric anesthetics occur in non‐operating room settings. Patients were more likely to have higher American Society of Anesthesiologists Physical Status classifications in the non‐operating room anesthesia group. Gastroenterological suites are the most common setting reported for pediatric non‐operating room anesthesia.ConclusionsNon‐operating room anesthesia in the United States is a prominent segment of pediatric anesthetic practice. Pediatric patients encountered in the non‐operating room setting have more comorbidities, though further studies are needed to characterize the implication of this finding.
Modeling current and future habitat suitability of an iconic bird to inform restoration planning in southeastern Louisiana, U.S.A.
Authors: Percy Katie L. , Michel Nicole L. , Nakashima Lindsay , Fuller Jennifer , Johnson Erik I. 
Published: February 2023

Louisiana is facing a land loss crisis with 5,000 km2 lost since the 1930s, and another 10,000 km2 may disappear over the next 50 years. In response, the state developed a Comprehensive Master Plan for a Sustainable Coast, which includes predictions for how wildlife species respond to futures with or without restoration action. However, the 2017 Master Plan did not include a bird species representative of brackish or freshwater wetland habitats. Our objective therefore was to evaluate the potential for the Bald Eagle (Haliaeetus leucocephalus) to serve as an indicator of freshwater wetland health, and to develop a model to predict Bald Eagle responses to land cover change 20 and 50 years into the future, with or without restoration action. Using nest location data collected by the Louisiana Department of Wildlife and Fisheries from the Barataria Basin, we modeled the relationship between Bald Eagle nest occurrence and land cover using boosted regression trees. Model performance was strong, explaining 54.4 ± 0.1% of the deviance in nest occurrence, and showed that Bald Eagle nests were more common in areas with greater fresh forested wetland, freshwater marsh, and flotant marsh land cover. Future suitability for nesting Bald Eagles was higher in 20 and 50 years with restoration action compared to without, although suitability in both years was lower than contemporary suitability, regardless of restoration action. Our model suggests that comprehensive restoration action is needed, including the implementation of Mississippi River diversions, to sustain high densities of nesting Bald Eagles in coastal Louisiana.
Considerable gaps and differences in rehabilitation after major lower extremity amputations across regions and municipalities in Denmark – A national survey
Authors: Madsen Ulla Riis , Biesbjerg Christian Bach , Mikkelsen Tina Broby , Marsaa Kristoffer , Olsen Zwisler Ann‐Dorthe , Vedste Aagaard Thomas 
Published: February 2023

AbstractIntroductionEqual access to healthcare is a fundamental principle in the fully tax‐financed Danish healthcare system. This study reveals whether this system lives up to the principle of equal access when it comes to the rehabilitation of patients who have major lower extremity amputations.MethodsWith the aim of exploring possible inequality in rehabilitation for patients having major lower extremity amputation in Denmark, a nationwide electronic survey was conducted in the autumn of 2020, which included all hospitals and municipalities in Denmark.ResultsEighty six percent of hospitals (n = 19) and 97% (n = 95) of municipalities responded. Of the 32% (n = 6) of hospitals and 78% (n = 74) of municipalities that provided prosthesis rehabilitation, the majority (hospitals 50% /municipalities 91%) provided prostheses for <10 patients in 2019, and 36% reported having competencies at only a general level among physiotherapists performing prosthetic training. Psychosocial rehabilitation modalities were lacking overall.ConclusionsThis national study documents pronounced geographic inequality in access to qualified rehabilitation services for the relatively few patients undergoing lower extremity amputations in Denmark. The decentralised organisation of amputation rehabilitation makes it difficult to build and maintain specialist competencies among healthcare professionals. Inconsistent availability of psychosocial rehabilitation modalities of all kinds found in this study points to a need for action particularly among patients not in prosthetic rehabilitation where palliative needs should also be considered.
Bioclastic bottom‐current deposits of a Devonian contourite terrace: Facies variability and depositional architecture (Tafilalt Platform, Morocco)
Authors: Hüneke Heiko , Gibb M. Arwed , Mayer Oliver , Kniest Jorit F. , Mehlhorn Paul , Gibb Laura M. , Aboussalam Z. Sarah , Becker R. Thomas , El Hassani Ahmed , Baidder Lahssen 
Published: February 2023

ABSTRACTThe study examines bioclastic carbonate contourites that arise from the broad spectrum of bottom‐current related sedimentary processes ranging from deposition to erosion. The result of the intermittent accumulation of sediment are thin and condensed successions with abundant hiatuses. Such bottom‐current deposits are poorly known, since the broadly accepted contourite‐facies model, the bi‐gradational sequence, characterizes environments of contourite depositional systems as a continuous accretion of fine‐grained siliciclastic sediments. To increase current understanding of the carbonate facies within hiatal contourite records, the Eifelian–Frasnian of the Tafilalt Platform in Morocco was investigated. The succession is divided into five facies associations that are interpreted to reflect pelagic sedimentation and deposition from bottom currents on a contourite terrace, a gently inclined section of the upper slope of Gondwana shaped by a water‐mass interface. Contourite deposition was mainly controlled by oxic clear‐water currents (documented by moderately to completely bioturbated limestones with abundant hydrogenetic ferromanganese nodules, and low organic‐carbon contents), at times also by an anoxic water mass (featured by organic‐rich coquinas with absent to sparse bioturbation and predominantly syngenetic framboidal pyrites). Biostratigraphic data and the overall depositional architecture display palaeoceanographic hydrodynamic processes associated with a shifting water‐mass interface. The inner terrace was characterized by an alongslope contourite channel and a small mounded drift at its downslope margin. Energetic bottom currents furthermore caused abraded surfaces, i.e. plain areas of non‐deposition and localized erosion, and sandy condensation layers. The microfacies reflects repeated alternation between suspension deposition, winnowing of fines, bedload traction, dynamic sediment bypassing and reworking, together with concomitant seafloor cementation. Coquinas of mainly planktonic and nektonic organisms are identified as integral parts of bi‐gradational contourite sequences showing inverse and normal grading. Hiatal lag concentrations of carbonate intraclasts, ferromanganese nodules and conodonts often drape hardgrounds and erosional surfaces at the midpoint of these frequently incomplete sequences. This Devonian case provides the opportunity to investigate the spatial and temporal variability of the bed‐scale contourite sequence, also with regard to the drift‐scale depositional architecture. In addition, the identified high‐resolution record is a starting point for unravelling the pattern of oceanic circulation in the Devonian greenhouse world.
Efficiency of cutaneous heat diffusion after local hyperthermia for the treatment of itch
Authors: Wohlrab Johannes , Mentel Tim , Eichner Adina 
Published: February 2023

AbstractBackgroundToday, itching is understood as an independent sensory perception, which is based on a complex etiology of a disturbed neuronal activity and leads to clinical symptoms. The primary afferents (pruriceptors) have functional overlaps with afferents of thermoregulation (thermoceptors). Thus, an antipruritic effect can be caused by antagonizing heat‐sensitive receptors of the skin. The ion channel TRP‐subfamily V member 1 (TRPV1) is of particular importance in this context. Repeated heat application can induce irreversible inactivation by unfolding of the protein, causing a persistent functional deficit and thus clinically and therapeutically reducing itch sensation.Material and methodsTo demonstrate relevant heat diffusion after local application of heat (45°C to 52°C for 3 and 5 seconds) by a technical medical device, the temperature profile for the relevant skin layer was recorded synchronously on ex vivo human skin using an infrared microscope.ResultsThe results showed that the necessary activation temperature for TRPV1 of (≥43°C) in the upper relevant skin layers was safely reached after 3 and 5 seconds of application time. There were no indications of undesirable thermal effects.ConclusionThe test results show that the objectified performance of the investigated medical device can be expected to provide the necessary temperature input for the activation of heat‐sensitive receptors in the skin. Clinical studies are necessary to prove therapeutic efficacy in the indication pruritus.
Biosocial borders: Affective debilitation and resilience among women living in a violently bordered favela
Authors: Brigstocke Julian , Fróes Maira , Cabral Cristina , Malanquini Lidiane , Baptista Gabriela 
Published: February 2023

AbstractWithin emerging fields of research focusing on neuro‐urbanism, neuro‐geographies, and biosociality, which experiment with using emerging mobile biosensor methods, few if any have used them to research socio‐spatial life in communities that suffer high levels of violence and other socio‐spatial injustices. Extending non‐representational accounts of the body, emotions, and affect, this paper discusses an experimental geography–neuroscience collaboration, working in a favela of Rio de Janeiro to explore the embodied urban emotions and affects of violently bordered urban communities. Emphasising non‐representational, corporeal spatial practices in a study of women living in Brazil's favelas, we use electrodermal activity biosensors to propose a novel methodological and analytical approach that focuses on forms of affective debilitation and resilience. Theoretically, we draw on biopolitical theory and border theory to propose a method that avoids oppositions between biopolitical and necropolitical accounts of borders. The aim of the research, conducted in June 2016, is to understand levels of affective debilitation or resilience among women living in the Maré Complex of favelas in Rio de Janeiro. Using a wearable biosensor, we took measures of electrodermal activity of eight women as they undertook one of their routine, everyday journeys within the favela. We also conducted an hour‐long qualitative interview with each participant. We find that for all our participants, navigating the favela's violent border spaces subjects their bodies to very high levels of affective and cognitive demand. While some women responded to this with stress reactions that created acute levels of affective debilitation, others responded very strongly, showing exceptionally high levels of affective resilience. Our research highlights the affective labour required of women to co‐construct urban borders, and emphasizes their agency and forms of everyday resistance in shaping the favela's affective atmospheres. Combined biosensing (electrodermal activity/galvanic skin response) data and interview data reveal that women living in the favela experience high levels of stress and fear. For one resident this results in affective debilitation (a wounding of the capacity to affect and to be affected). However, other women showed exceptionally high levels of affective resilience and resistance. The research points to the important role of women in co‐constructing the embodied borders of the favela.
Injustiça Climática
Authors: Scotti Rodrigues Guilherme , Pereira Diego 
Published: February 2023

De que forma as iniquidades advindas das questões climáticas são um adicional às desigualdades sociais que atravessam a sociedade brasileira? Como a negação de direitos presenciada em casos de desastres ambientais corresponde a um tipo de violência? Por que discutir meio ambiente passou a ressignificar a própria ideia de democracia e estado de direito? São esses os questionamentos que conduzem a escrita do presente artigo que, tracejando o significado de justiça climática como oriunda da justiça ambiental, chama ao debate os direitos humanos em busca da diminuição de vulnerabilidades das mais variadas espécies. Assim, apresenta-se como objeto de estudo a análise da injustiça agravada pela questão climática que, na contemporaneidade, implica violação de um rol de garantias previsto no texto constitucional pátrio. Nesse sentido, o objetivo principal deste artigo é apontar como a justiça climática evita o fomento de desigualdades. Para isso, partimos de conceitos caros ao debate da justiça no país, como violência, desigualdade e garantias de direitos.
Pobreza Multidimensional e Encarceramento Feminino:
Authors: Andrade Denise Almeida de , Bertolin Patrícia Tuma Martins , Bessa Leandro Sousa 
Published: February 2023

A pobreza é uma mazela social e econômica recorrente na história do Brasil e temos avançado, especialmente, nas últimas décadas na compreensão da pobreza como uma realidade multidimensional. A partir disso, buscamos estabelecer um fio condutor que demonstra a relação entre pobreza multidimensional, feminização da pobreza e aumento do encarceramento feminino no Brasil. Objetivamos demonstrar que apenas rompendo com o paradigma da subalternização das mulheres é possível superar a pobreza multidimensional no País. Para tanto, realizamos revisão de literatura atual e especializada e analisamos dados sobre o mercado de trabalho e salário à luz da realidade das mulheres.Percebemos que o aumento do encarceramento feminino diálogo inexoravelmente com esse cenário de subjugação histórica e que a política antidrogas submete as mulheres a penas que ultrapassam o encarceramento.
Pobreza e o Exercício da Maternidade:
Authors: Dantas Germano Gomes Janaína 
Published: February 2023

O presente artigo busca aproximar dados empíricos obtidos em duas pesquisas distintas, para ilustrar a potencialidade de se pensar, no contexto de processos judiciais, as perspectivas consensuais acerca da pobreza. Utilizando o material obtido no contexto de uma pesquisa coletiva sobre pobreza multidimensional, restituiu-se o conteúdo de um grupo focal de mulheres vivendo em alta vulnerabilidade em um centro de acolhida especializado. A partir de um dos processos analisados sede de doutorado, descreve-se de maneira sintética o processo, destacando-se informações que apontam, da perspectiva do poder judiciário, como a pobreza e privação material da família inviabilizaria o cuidado da criança recém-nascida, posteriormente destituída do poder familiar. As famílias pobres, desde sua própria experiência, não se consideram pobres a ponto de colocar as crianças em risco, e reivindicam a permanência da família conjuntamente. O poder judiciário, por sua vez, produz autos que indicam que há requisitos mínimos que vão além daquilo que as famílias possuem ou oferecem, justificando a separação em nome do bem estar da criança. Por meio destes materiais, reflete-se a partir do arcabouço teórico metodológico da abordagem consensual da pobreza, sobre como os elementos que definem “pobreza”, em diferentes contextos, são centrais para a atuação do Estado. Neste caso em concreto, podem acarretar em decisões complexas e irrevogáveis, como a separação definitiva entre mães e filhos.
Status and developments of target production for research on heavy and superheavy nuclei and elements
Authors: Lommel Bettina , Düllmann Christoph E. , Kindler Birgit , Renisch Dennis 
Published: February 2023

AbstractWe give an overview of the special challenges regarding target development and production for accelerator-based heavy and superheavy-nuclei experiments in the past and perspectives for the future. Production of ever heavier elements, studies of heavy-element production in fusion or transfer reactions, spectroscopic investigations on their nuclear structure and decay and on the fission processes with fragment analyses, laser spectroscopic studies of their atomic structure, high-precision mass measurements as well as chemical studies are lively fields of current science. The ever-increasing beam intensities, feasible with new accelerator development, are crucial for the synthesis of superheavy elements because of the low cross sections for many of the reactions. Therefore, the development of target and backing materials with higher durability and experiment lifetime is increasingly important. Here we concentrate on the techniques necessary for the production of targets that are needed for experiments in this special field of interest. For the future, also development on target monitoring, target cooling, and beam intensity profile shaping techniques will play an important role, but are not in the focus of this article.
Impact of Preoperative Quality of Life and Related Factors on the Development of Surgical Site Infections Following Primary Total Joint Arthroplasty: A Prospective Case-Control Study with a Five-Year Follow-Up
Authors: Iliopoulou-Kosmadaki Styliani , Hadjimichael Argyris C. , Kaspiris Angelos , Lianou Ioanna , Kalogridaki Marina , Trikoupis Ioannis , Touzopoulos Panagiotis , Velivasakis Emmanuel , Sperelakis Ioannis , Laskaratou Emmanouela Dionysia , Melissaridi Dimitra , Vasiliadis Elias , Kontakis Georgios , Papagelopoulos Panagiotis J. , Savvidou Olga D. 
Published: February 2023

Introduction. As surgical site infections (SSIs) after joint arthroplasty contribute to increased morbidity and mortality, they require further surgical intervention, prolonged hospitalisation, and antimicrobial treatment. The aim of our study is to examine the association between preoperative quality of life (QoL) and other predictive factors on the development of SSIs after primary arthroplasty. Methods. This is a prospective study that enrolled 56 patients with hip and knee primary osteoarthritis who underwent joint replacement. Data were collected from January to March 2017, including patient demographic characteristics, comorbidities, laboratory results, and perioperative clinical data. The patients’ QoL was evaluated preoperatively by applying the knee injury and osteoarthritis outcome score (KOOS) and the hip disability and osteoarthritis outcome score (HOOS) for total knee replacement (TKR) and total hip replacement (THR), respectively. A 5-year follow-up was conducted to assess the clinical status of the patients. Results. 66.1% of patients underwent TKR, with 4.9 ± 1.2 days of hospitalisation, 16% of them required autologous blood transfusion, while 33.9% of patients were treated with THR, with 5.7 ± 1 days hospitalisation and 36.8 of them required this type of transfusion. 16 patients were diagnosed with SSIs, with the older of them (>65 years old) presenting lower probability (odds ratio: 0.13, 95% CI: 0.03–0.62) requiring treatment with additional antibiotics, while revision surgery was performed in 3 of these cases, following periprosthetic joint infection (PJI). Overall preoperative QoL was not statistically associated with SSIs, but low QoL scores were associated with higher rates of SSIs and increased levels of postoperative pain (

p

= 0.009 < 0.05). Conclusions. The duration of each operation (>90 min), the length of hospitalisation (>4 days), and the presence of comorbidities including hypothyroidism and recurrent urinary tract infections were associated with a high risk for SSIs following arthroplasties. On the contrary, this study revealed no association between other comorbidities, including heart coronary disease, hypertension, and diabetes mellitus, with close monitoring of plasma glucose and SSIs. Moreover, the younger the patients, the more likely they were to require treatment with antibiotics. Overall, high QoL index scores were mainly accompanied by low rates of postoperative SSIs and pain.
Phase I Study of the Liposomal Formulation of Eribulin (E7389-LF): Results from the Advanced Gastric Cancer Expansion Cohort
Authors: Shitara Kohei , Hirao Motohiro , Iwasa Satoru , Oshima Takashi , Komatsu Yoshito , Kawazoe Akihito , Sato Yasuyoshi , Hamakawa Takuya , Yonemori Kan , Machida Nozomu , Yuki Satoshi , Suzuki Takuya , Okumura Shiori , Takase Takao , Semba Taro , Zimmermann Bob , Teng Angela , Yamaguchi Kensei 
Published: February 2023

AbstractPurpose:In the dose-expansion part of this open-label, phase I study, we explored the efficacy and safety of E7389-LF (liposomal formulation of eribulin) in Japanese patients with advanced gastric cancer.Patients and Methods:Patients with advanced gastric cancer who had been previously treated with ≥2 lines of chemotherapy received E7389-LF 2.0 mg/m2 every 3 weeks (the previously determined maximum tolerated dose, the primary objective of Study 114). Secondary objectives included objective response rate (ORR), progression-free survival (PFS), and safety; exploratory objectives included disease control rate (DCR) and clinical benefit rate (CBR), as well as pharmacodynamic measurements of serum biomarkers.Results:As of June 24, 2021, 34 patients were enrolled and treated (10 from the original dose-expansion cohort, expanded to include 24 additional patients). Six patients had partial responses, for an ORR of 17.6% [95% confidence interval (CI), 6.8–34.5], and the median PFS was 3.7 months (95% CI, 2.7–4.8). The DCR was 79.4% (95% CI, 62.1–91.3), and the CBR was 32.4% (95% CI, 17.4–50.5). Overall, 32 patients (94.1%) experienced treatment-related adverse events, and 26 patients (76.5%) experienced grade ≥3 events, most commonly neutropenia (41.2%) and leukopenia (29.4%). Of the 8 endothelial cell/vasculature markers tested in this study, 7 were significantly increased among patients treated with E7389-LF; these changes were generally consistent regardless of best overall response.Conclusions:E7389-LF 2.0 mg/m2 every 3 weeks was tolerable and showed preliminary activity for the treatment of patients with gastric cancer.