bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of HR-HPV infection on oncological outcomes in early cervical cancer
Authors: Su Xiaoqiang , Liu Pan , Zhao Hongwei , Sun Lixin , Wang Wuliang , Jin Shuanglin , Wang Hui , Liu Ping , Chen Chunlin , Hao Min 
Published: August 2023

BackgroundThis study aimed to investigate the differences in long-term oncological outcomes between high-risk human papillomavirus (HR-HPV) negative and HR-HPV positive early-stage cervical cancers.MethodsWe retrospectively analysed 2061 cases of early-stage cervical cancer from the Chinese cervical cancer clinical diagnosis and treatment database. Kaplan-Meier curves were used to describe the survival outcomes of different HR-HPV infections. Cox proportional hazard regression model was used to analyze and determine independent risk factors.ResultsK-M analysis revealed no significant difference in 5-year OS between HR-HPV negative and HR-HPV positive groups (OS: 95.0% vs.95.6%, P=0.900). A significant difference was observed in 5-year DFS between the HR-HPV negative and HR-HPV positive groups (DFS: 87.2% vs.91.9%, P=0.025). Cox proportional hazard regression model indicated that HR-HPV infection (negative vs. positive) was an independent factor influencing 5-year DFS after early cervical cancer surgery (DFS: hazard ratio [HR]=1.862, P=0.022). HR-HPV infection (negative vs positive) was not an independent factor influencing 5-year OS after early cervical cancer surgery (OS: P=0.813). After 1:1 PSM pairing, there was no significant difference in 5-year OS and DFS between HR-HPV negative group and HR-HPV positive group (OS: 91.6% vs.95.0%, P=0.297; DFS: 87.2% vs.85.1%, P=0.758). Cox multivariate analysis indicated that HR-HPV infection was not an independent factor influencing 5-year OS and DFS after early cervical cancer surgery (OS: P=0.806, DFS: P=0.251).ConclusionsThe tumour results of HR-HPV negative group and HR-HPV positive group were similar, after eliminating the differences in known variables that affect the oncological outcomes of cervical cancer. The treatment plan of HR-HPV positive cervical cancer is suitable for HR-HPV negative cervical cancer.
Synthesis of an insulin-loaded mucoadhesive nanoparticle designed for intranasal administration: focus on new diffusion media
Authors: Jamshidnejad-Tosaramandani Tahereh , Kashanian Soheila , Karimi Isaac , Schiöth Helgi B. 
Published: August 2023

Intranasal administration is a drug delivery approach to provide a non-invasive pharmacological response in the central nervous system with relatively small peripheral side effects. To improve the residence time of intranasal drug delivery systems in the nasal mucosa, mucoadhesive polymers (e.g., chitosan) can be used. Here, insulin-loaded chitosan nanoparticles were synthesized and their physiochemical properties were evaluated based on requirements of intranasal administration. The nanoparticles were spherical (a hydrodynamic diameter of 165.3 nm, polydispersity index of 0.24, and zeta potential of +21.6 mV) that granted mucoadhesion without any noticeable toxicity to the nasal tissue. We applied a new approach using the Krebs–Henseleit buffer solution along with simulated nasal fluid in a Franz’s diffusion cell to study this intranasal drug delivery system. We used the Krebs–Henseleit buffer because of its ability to supply glucose to the cells which serves as a novel ex vivo diffusion medium to maintain the viability of the tissue during the experiment. Based on diffusion rate and histopathological endpoints, the Krebs–Henseleit buffer solution can be a substituent solution to the commonly used simulated nasal fluid for such drug delivery systems.
Manipulation of magnetization and spin transport in hydrogenated graphene with THz pulses
Authors: Svaneborg Jakob Kjærulff , Bach Lorentzen Aleksander , Gao Fei , Jauho Antti-Pekka , Brandbyge Mads 
Published: August 2023

Terahertz (THz) field pulses can now be applied in scanning tunneling microscopy (THz-STM) junction experiments to study time-resolved dynamics. The relatively slow pulse compared to the typical electronic time-scale calls for approximations based on a time-scale separation. Here, we contrast three methods based on non-equilibrium Green’s functions: i) the steady-state, adiabatic results, ii) the lowest-order dynamic expansion in the time variation, and iii) the auxiliary mode propagation method without approximations in the time variation. We consider a concrete THz-STM junction setup involving a hydrogen adsorbate on graphene where the localized spin polarization can be manipulated on/off by a local field from the tip electrode and/or a back-gate affecting the in-plane transport. We use steady-state non-equilibrium Green’s function theory combined with density functional theory to obtain a Hubbard model for the study of the junction dynamics. Solving the Hubbard model in a mean-field approximation, we find that the near-adiabatic first-order dynamic expansion in the time variation provides a good description for STM voltage pulses up to the 1 V range.
Vowel production: a potential speech biomarker for early detection of dysarthria in Parkinson’s disease
Authors: Roland Virginie , Huet Kathy , Harmegnies Bernard , Piccaluga Myriam , Verhaegen Clémence , Delvaux Véronique 
Published: August 2023

ObjectivesOur aim is to detect early, subclinical speech biomarkers of dysarthria in Parkinson’s disease (PD), i.e., systematic atypicalities in speech that remain subtle, are not easily detectible by the clinician, so that the patient is labeled “non-dysarthric.” Based on promising exploratory work, we examine here whether vowel articulation, as assessed by three acoustic metrics, can be used as early indicator of speech difficulties associated with Parkinson’s disease.Study designThis is a prospective case–control study.MethodsSixty-three individuals with PD and 35 without PD (healthy controls-HC) participated in this study. Out of 63 PD patients, 43 had been diagnosed with dysarthria (DPD) and 20 had not (NDPD). Sustained vowels were recorded for each speaker and formant frequencies were measured. The analyses focus on three acoustic metrics: individual vowel triangle areas (tVSA), vowel articulation index (VAI) and the Phi index.ResultstVSA were found to be significantly smaller for DPD speakers than for HC. The VAI showed significant differences between these two groups, indicating greater centralization and lower vowel contrasts in the DPD speakers with dysarhtria. In addition, DPD and NDPD speakers had lower Phi values, indicating a lower organization of their vowel system compared to the HC. Results also showed that the VAI index was the most efficient to distinguish between DPD and NDPD whereas the Phi index was the best acoustic metric to discriminate NDPD and HC.ConclusionThis acoustic study identified potential subclinical vowel-related speech biomarkers of dysarthria in speakers with Parkinson’s disease who have not been diagnosed with dysarthria.
The relationship between resilience and quality of life in advanced cancer survivors: multiple mediating effects of social support and spirituality
Authors: Chen Cancan , Sun Xiaofei , Liu Zhenya , Jiao Miaorui , Wei Wanhong , Hu Yanli 
Published: August 2023

BackgroundWhile previous studies have revealed a positive association between resilience and quality of life in advanced cancer survivors, the mechanisms of the relationship is still unclear. This study aimed to explore the relationships between resilience, social support, spirituality, and quality of life and determine the multiple mediation effects of social support and spirituality on the relationship between resilience and quality of life.MethodsWith 286 advanced cancer survivors, a cross-sectional, correlational survey was adopted using convenience sampling. Resilience, social support, spirituality, and quality of life were evaluated by self-report questionnaires. The PROCESS macro for SPSS was used to test the multiple mediation model.ResultsThe scores for resilience, social support, spirituality and quality of life were positively correlated with one another. Resilience was found to be directly impact quality of life. Meanwhile, the relationship between resilience and quality of life was mediated by social support (effect = 0.067, 95% CI [0.019, 0.120]) and by spirituality (effect = 0.221, 95% CI [0.134, 0.332]), respectively, and by these two serially (effect = 0.036, 95% CI [0.015, 0.067]).ConclusionSocial support and spirituality played multiple mediating roles in the relationship between resilience and quality of life. Interventions aimed at increasing resilience, and then boosting social support and spirituality may be beneficial for promoting quality of life of advanced cancer survivors.
Characteristics of Fluctuating Wind Speed Spectra of Moving Vehicles under the Non-Stationary Wind Field
Authors: Hu Peng , Zhang Fei , Han Yan , Yan Naijie 
Published: August 2023

To promote energy saving, emission reduction, and sustainable development of high-speed trains, as well as achieve low-carbon operation of these trains. It is necessary to establish a fluctuating wind speed spectra model that can accurately describe the characteristics of the fluctuating wind speed field of the moving vehicle. This will help explore the effects of strong winds on the running resistance, energy consumption, safety, and comfort of trains. In this paper, based on Priestley’s evolutionary power spectral density (EPSD) theory, an efficient method was developed for generating the fluctuating wind speeds at the moving point under the non-stationary wind field. On such basis, the effects of different mean wind speeds, ground clearances, temporal modulation function parameters, and vehicle’s moving speeds on the time-varying correlation function ratio of fluctuating wind speed at fixed and moving points were analyzed. Subsequently, the relationship between the time-varying correlation functions of fluctuating wind speed at the fixed and moving points was established by analyzing the sensitivity of the above parameters, and a theoretical model of fluctuating wind speed spectra of the moving point under the non-stationary wind field was proposed. In addition, the relational expression of fluctuating wind speed spectra of the moving point under stationary and non-stationary wind fields was established, which was further validated using the fluctuating wind speed spectra model at the fixed points with different modulation function forms. The results demonstrated that the direct generation method can avoid n times of POD decomposition and Ns∑j=1nNqjj times of FFT calculation, improve the calculation speed, and save memory. The proposed fluctuating wind speed spectra model at the moving point under the non-stationary wind field is in good agreement with the corresponding target one, indicating the high accuracy of the proposed model. Meanwhile, it is also noted that the fluctuating wind speed spectra at the moving point under the non-stationary wind field can be obtained by modulating the spectra under the stationary wind field using temporal modulation function, which is the same as that of the fluctuating wind speed spectra at fixed points under the non-stationary wind field.
REVIEW OF CURRENT REGULATORY DOCUMENTS ASSOCIATED WITH TECHNOLOGICAL DESIGNING OF CATTLE FARMS
Authors: ХАЗАНОВ В.Е. , ГОРДЕЕВ В.В. , ГОРДЕЕВА Т.И. 
Published: August 2023

Одним из условий повышения эффективности производства молока, уменьшения затрат и улучшения условий труда для животноводов является модернизация ферм с внедрением технологий беспривязного содержания и обслуживания скота. Благодаря программе субсидирования кредитов, активно ведутся реконструкция старых и строительство новых молочных ферм во всех регионах страны. Наличие проектной документации, прошедшей экспертизу, является одним из условий субсидирования. При ее разработке, как для реконструкции старых, так и для строительства новых ферм и комплексов, проектировщики обязаны соблюдать действующие в стране нормативы, изложенные в рекомендациях, правилах и др. Данные документы можно разделить на технологические, строительные, экологические, зоотехнические и ветеринарные. Основными из них, регламентирующими требования к разделу проектной документации «Технологические решения», являются РД-АПК 1.10.01.01-18 «Методические рекомендации по технологическому проектированию ферм и комплексов крупного рогатого скота» и Приказ Министерства сельского хозяйства РФ от 21 октября 2020 г. № 622 «Об утверждении ветеринарных правил содержания крупного рогатого скота в целях его воспроизводства, выращивания и реализации». Анализ нормативных параметров в приведенных выше документах выявил несоответствие их требованиям современных ферм, что показывает необходимость их корректировки на основе проведения научных исследований и опыта эксплуатации новых ферм.
A prerequisite for advancing the milk production efficiency, lowering the costs, and improving the work environment of farm personnel is to upgrade the farms through introducing the free-stall cattle housing and caring. Owing to the state subsidy program, an active reconstruction of old dairy farms and construction of new ones is in progress in all country regions. The available design documentation having passed the expert examination is important to receive a subsidy. When developing the design documentation for construction/ reconstruction of cattle farms, the designers must follow the valid national standards as set out in the recommendations, rules, and other documents. The latter may be classified into technological, construction, environmental, zootechnical, and veterinary ones. Two major documents govern the requirements of the “Technological solutions” section within the design documentation. They are the Management Directive for Agro-Industrial Complex RD-APK 1.10.01.01-18 “Recommended Practice for Engineering Designing of Cattle Farms and Complexes” and the Order of the Agriculture Ministry of the Russian Federation of October 21, 2020 N 622 “On approval of veterinary rules for cattle housing for its reproduction, growing and marketing.” The close consideration of norms specified in the above documents revealed their inconsistency with the modern farm requirements. This proved the need for revision and corrections based on relevant research and operating experience of new farms.
La obesidad como factor de riesgo de gravedad por la infección de COVID-19
Authors: Villarreal Rodríguez Humberto Guillermo , Hijar Guzman Raymundo Javier , Ccaira Mamani Cirilo Mario , Cahuana Flores Jaime Braulio , Legua Cárdenas José Antonio 
Published: August 2023

Los nuevos estilos de vida forzados por la pandemia, han mostrado un incremento en la incidencia en los niveles de índice de masa corporal de sobrepeso y obesidad en la población, a su vez estos casos, se visibilizaban más al estar relacionados con casos de gravedad por la enfermedad del COVID-19. Objetivo. Relacionar que el sobrepeso y obesidad, si son factores de riesgo y predicción de situaciones de gravedad por infección del COVID-19. Materiales y métodos. Se realizó un estudio, tipo descriptivo correlacional. Para esta investigación, se tomó muestra poblacional de personal voluntario de 48 personas, principalmente constituido por estudiantes y algunos docentes que pertenecen a la Facultad de Educación de la Universidad Nacional José Faustino Sánchez Carrión. Este personal fue evaluado en dos clínicas ubicadas en ciudades diferentes, la información biométrica y resultados de análisis de sangre, se consultó con personal médico asesor. Luego de un año se realizó una segunda evaluación, mediante una encuesta, para recabar información sobre la respuesta del sistema inmune del personal evaluado, ante una infección COVID-19 si fuera el caso. Se realizó la consulta médica respecto a los resultados obtenidos, sobre la correlación entre la obesidad, como factor de riesgo en el nivel de gravedad de la enfermedad COVID-19. Resultados. Se determinó que 13 personas evaluadas que corresponden: al 27.08% del total, registraron sobrepeso y presentaron clínicas leves o severas ocasionadas por el COVID-19. Conclusiones. Por lo que, este resultado demuestra que en personas con sobrepeso son propensos a padecer diversas enfermedades, esta situación de su comorbilidad, los expone a alto riesgo de llegar a situaciones graves de su salud por la infección del COVID-19.
Plantas medicinales que se expende en mercado de Barranca para aliviar las afecciones respiratorias
Authors: Castañeda Chirre Elvira Teófila , Valderrama Rios Olga Giovanna , Porras Roque María Soledad , More López Jesús Manuel , Chanducas Tantaleán Heber Elcano , Romero Menacho Jaime Ulices , Vélez Chang Yasmín Jesús 
Published: August 2023

Muchos años han pasado hasta hoy, donde las plantas medicinales juegan un papel importante en tratamiento de muchas enfermedades y aún falta investigar más sobre sus propiedades. Objetivo. Determinar la relación que hay entre consumo de plantas medicinales y alivio de enfermedades respiratorias de trabajadores del mercado el Milagro. Materiales y métodos. Se basó en estudio descriptivo con enfoque cuantitativo, prospectivo y observacional, se enfocó en edades de 20 a 60 años, ambos sexos quienes participaron voluntariamente. Se tomó datos desde junio hasta setiembre del 2021 de muestra de 60 trabajadores. Se recolectaron datos de dimensiones del consumo de plantas medicinales y relación entre plantas y alivio de enfermedades respiratorias por semana, luego se promedió por mes de allí se procesaron mediante estadísticas básicas y correlación. Resultados. Se pudo determinar que consumieron plantas medicinales como eucalipto, escorzonera y huamanripa para afecciones respiratorias en agosto con 3% y setiembre con 5% eucalipto para COVID-19; consumieron hierbas medicinales como eucalipto, escorzonera y huamanripa como infusiones destacó agosto con 7%; consumieron hierbas medicinales para enfermedades respiratorias destacó julio con 25% y setiembre con 64 % para COVID-19; consumieron hierbas para aliviar síntomas del coronavirus sobresalió setiembre con 80% y correlación entre consumo de hierbas y alivio de síntomas de COVID-19 obtuvo r = 0.8946. Conclusiones. Se pudo establecer que existe una alta relación entre consumo de plantas medicinales y alivio de síntomas este virus y afecciones respiratorias; por lo tanto, los consumos de hierbas en muchos casos conjuntamente con terapia médica mejoraron las dolencias de estas enfermedades.
Estilo de vida y estado nutricional en estudiantes de una universidad pública peruana
Authors: Castro Galarza Cesar Raúl , García Huamaní Rubén , Ricra Echevarría Carmen Rocío , Fretel Quiroz Nicolás Magno , Inga Huayllani Germán , Álvarez Gamarra Lizbeth Karina 
Published: August 2023

Las alteraciones del estado nutricional es un problema que afecta a los estudiantes de las universidades, esto se debe en gran medida del estilo de vida que mantienen dentro de su condición socioeconómica, afectando de esta manera el éxito académico. Objetivo. Identificar la relación que existe entre el estilo de vida y el estado nutricional en estudiantes de la Universidad Nacional Autónoma Altoandina de Tarma – Junín, 2021. Materiales y métodos. Se desarrolló una investigación observacional, de diseño no experimental, de nivel correlacional, de tipo transversal y prospectivo; la población de estudio lo constituyeron el total de estudiantes de la universidad, se tuvo una muestra de 90 estudiantes, se usó la técnica de la encuesta y el instrumento fue un cuestionario para evaluación del estilo de vida en universitarios. Resultados. El estilo de vida predominante es la categoría de malo (38.89%), el 26.67% de estudiantes lleva un estilo de vida pésimo, y solo el 3.33% de estudiantes lleva un estilo de vida excelente; sin embargo, el 76.67% de estudiantes tienen un estado nutricional normal, el 18.89% de estudiantes tiene sobrepeso, y un total de 4,44% de estudiantes presenta delgadez u obesidad. Conclusiones. Se pudo establecer que existe una relación negativa baja entre el estilo de vida y el estado nutricional, lo que quiere decir, que el aspecto socioeconómico afecta la sostenibilidad y permanencia del estudiante dentro de la carrera universitaria, lo que significa que muchos de ellos, no llegasen a culminar sus estudios.
La maison à pans de bois aux XVe et XVIe siècles dans quelques villes du Val de Loire et du Berry
Authors: Toulier Bernard 
Published: August 2023

Die Untersuchung alter Fachwerkhäuser wird durch die Zerstörungen und die Umbauten, die zu verschiedenen Zeiten in den übriggebliebenen Häusern vorgenommen wurden, verständlicherweise behindert. Ein anderes Problem ergibt sich aus der Schwierigkeit, diese Häuser zu datieren. Nicht mehr als 10% sind mit Jahreszahlen versehen. Noch zu selten wird von den Methoden der Dendrochronologie Gebrauch gemacht.
Das «Käfig-Haus», das sich durch Fachwerk an allen vier Seiten auszeichnet, bleibt die Ausnahme. Vom Beginn des 16. Jahrhunderts an vermehren sich die Erdgeschosse aus Stein. Ein anderes Modell stellen die Häuser mit Seiten wänden aus Stein und «Blend fassade» aus Holz dar.
Die Verteilung der Belastung zwischen oberem Stock und Fußboden wird durch einen Vorsprung oder einen senkrechten Abschluß der Fassadenmauer erreicht. Der Vorsprung kann ein vorkragender Träger sein, der mit den Deckenbalken verzahnt ist, oder aber auf senkrechten, oben verbreiterten Pfosten aufruhen, wobei die Schwelle auf dem Kopf des Postens liegt.
Der senkrechte Abschluß entwickelt sich im 16. Jahrhundert nach einem königlichen Edikt. Er wird durch ein System von Verbindungen mit kurzen oder langen Hölzern oder ohne Pfosten erzielt.
Es besteht ein enger Zusammenhang zwischen dem Holzskelett und der Füllung der Konstruktion. Man unterscheidet verschiedene Typen von Fachwerk. Unter den ländlichen Fachwerkbauten ist das einfachste ein «Gitter»-Fachwerk, mit oder ohne Entlastungsbalken. Vom 15. Jahrhundert an wird in Anger diese Bauweise durch Fachwerk in Form von großen Andreaskreuzen ersetzt. Die technisch anspruchsvollen Fachwerkkonstruktionen sind ein dekoratives Element an der Fassade. Die Rauten sind bezeichnend für die Häuser der «Spitzenklasse».
Trotz einer gewissen Einheitlichkeit in den angewendeten Methoden erhalten sich lokale Traditionen und in einigen Fällen ist die funktionelle Tradition der Mode überlegen. So zum Beispiel im Falle des überhängenden Dachstuhls in Giebelhäusern aus der zweiten Hälgte des 16. Jahrhunderts. Es scheint als hätten die Zimmerleute erst nach den Steinmetzen die neuen Formen der Renaissance angenommen.
Juan Goytisolo : le masque monstrueux, perversion et subversion
Authors: Perrin Annie 
Published: August 2023

Se trata
1 -de mostrar cómo el estatuto semiológico del monstruo, establecido a partir de un extracto del primer capítulo de Makbara, coincide con el de la víctima emisaria, con lo cual quedará evidente el vínculo estrecho que une los dos signos de la exibición y de la exclusión 2 -de ampliar estas conclusiones al conjunto de la obra de ruptura, desde Señas de Identidad (1966) hasta La Cuarentena (1991) sacando a luz :
a -cómo la mirada de los otros es simultáneamente vector de la exibición -mediante la constitución de la máscara monstruosa – e instrumento del sacrificio de la víctima emisaria
b -cómo el texto subvierte a su vez la práctica de exibición/sacrificio, la cual se basa en una práctica pervertida de la mirada.