bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pituitary Surgery in Germany – Findings from the European
Pituitary Adenoma Surgery Survey
Authors: Ottenhausen Malte , Conrad Jens , Kalasauskas Darius , Netuka David , Ringel Florian 
Published: March 2023

Abstract
Background Surgery is, next to medical and radiation therapy, the mainstay
therapy for pituitary adenomas. While scientific consensus regarding the key
aspects of pituitary surgery exists among neurosurgeons, procedures are not
standardized and might vary significantly between hospitals and surgeons.
Objective To provide an overview of how neurosurgical departments in
Germany manage pituitary surgery.
Methods Responses from the European Pituitary Adenoma Surgery Survey were
analyzed. The survey contained 60 questions regarding demographics, training,
surgical and endocrinological aspects, and patient management.
Results Sixty neurosurgical centers from Germany responded to the survey.
Among the centers, 35.3% (n=18) exclusively use the microscopic
and 31.1% (n=14) the endoscopic technique; all other centers
(n=28) use both approaches. Of responding centers, 20%
(n=12) perform less than 10 transsphenoidal pituitary surgeries per
year, and 1.7% (n=1), more than 100 operations. The number of
transcranial pituitary operations is significantly smaller, with 53.3%
of centers performing only 0–2 per year, 35% performing
3–5, and only one center (1.7%) performing more than 15
transcranial operations per year. In 8 centers (13.3%), surgeries are
always performed together with an ENT surgeon; in 29 centers (48.4%) ENT
surgeons are never involved. In most centers (n=54, 90%)
intraoperative MRI is not available. Image guidance (with preoperative CT
and/or MRI data) is used by 91.7% of respondents (n=55).
Forty-two centers (72.4%) routinely prescribe hydrocortisone after
pituitary surgery, and 75% (n=45) have pituitary board meetings
with endocrinologists, radiologists, and radiosurgeons. Fifty-two
(86.7%) respondents perform the first follow-up scan by MRI 3–4
months after surgery.
Conclusions The data showed differences as well as similarities between
centers and could help to discuss the standardization of methods and the
formation of networks and certification to improve patient care.
Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis
Authors: Wang Xinkang , Li Qiu , Du Fuyong , Shukla Neetu , Nawrocki Andrea R. , Chintala Madhu 
Published: March 2023

Background Factor XIa (FXIa) is an emerging therapeutic target, and FXIa inhibition is a promising mechanism to improve therapeutic index over current anticoagulants. Milvexian (BMS-986177/JNJ-70033093) is an oral small-molecule FXIa inhibitor.
Objective Milvexian's antithrombotic efficacy was characterized in a rabbit arteriovenous (AV) shunt model of venous thrombosis and compared with the factor Xa inhibitor apixaban and the direct thrombin inhibitor dabigatran.
Methods The AV shunt model of thrombosis was conducted in anesthetized rabbits. Vehicle or drugs were administered as intravenous bolus plus a continuous infusion. Thrombus weight was the primary efficacy endpoint. Ex vivo activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin time (TT) were measured as the pharmacodynamic responses.
Results Milvexian dose dependently reduced thrombus weights by 34.3 ± 7.9, 51.6 ± 6.8 (p < 0.01; n = 5), and 66.9 ± 4.8% (p < 0.001; n = 6) versus vehicle at 0.25 + 0.17, 1.0 + 0.67, and 4.0 ± 2.68 mg/kg bolus + mg/kg/h infusion, respectively. Ex vivo clotting data supported a dose-dependent prolongation of aPTT (with 1.54-, 2.23-, and 3.12-fold increases from baseline upon the AV shunt start), but no changes in PT and TT. Dose-dependent inhibition in thrombus weight and clotting assays was also demonstrated for both apixaban and dabigatran as the references for the model validation.
Conclusion Results demonstrate that milvexian is an effective anticoagulant for prevention of venous thrombosis in the rabbit model, which supports the utility of milvexian in venous thrombosis, as seen in the phase 2 clinical study.
Visible-Light-Mediated Regioselective Chlorosulfonylation of Acrylamides
Authors: Merino Estíbaliz , Zurro Mercedes , Torres-Oya Sergio , Otárola Guillermo G. , Vaquero Juan José 
Published: March 2023

AbstractA one-step chlorosulfonylation of acrylamides via a photocatalytic redox process is described. This reaction provides α-chlorosulfonylamides with a quaternary center with high regioselectivity via radical process. It is amenable to a broad range of substrates and the products are obtained in moderate to good yields.
Structure of mycobacterial respiratory complex I
Authors: Liang Yingke , Plourde Alicia , Bueler Stephanie A. , Liu Jun , Brzezinski Peter , Vahidi Siavash , Rubinstein John L. 
Published: March 2023

Oxidative phosphorylation, the combined activity of the electron transport chain (ETC) and adenosine triphosphate synthase, has emerged as a valuable target for the treatment of infection by
Mycobacterium tuberculosis
and other mycobacteria. The mycobacterial ETC is highly branched with multiple dehydrogenases transferring electrons to a membrane-bound pool of menaquinone and multiple oxidases transferring electrons from the pool. The proton-pumping type I nicotinamide adenine dinucleotide (NADH) dehydrogenase (Complex I) is found in low abundance in the plasma membranes of mycobacteria in typical in vitro culture conditions and is often considered dispensable. We found that growth of
Mycobacterium smegmatis
in carbon-limited conditions greatly increased the abundance of Complex I and allowed isolation of a rotenone-sensitive preparation of the enzyme. Determination of the structure of the complex by cryoEM revealed the “orphan” two-component response regulator protein MSMEG_2064 as a subunit of the assembly. MSMEG_2064 in the complex occupies a site similar to the proposed redox-sensing subunit NDUFA9 in eukaryotic Complex I. An apparent purine nucleoside triphosphate within the NuoG subunit resembles the GTP-derived molybdenum cofactor in homologous formate dehydrogenase enzymes. The membrane region of the complex binds acyl phosphatidylinositol dimannoside, a characteristic three-tailed lipid from the mycobacterial membrane. The structure also shows menaquinone, which is preferentially used over ubiquinone by gram-positive bacteria, in two different positions along the quinone channel, comparable to ubiquinone in other structures and suggesting a conserved quinone binding mechanism.
Potential Psychosocial Explanations for the Impact of Pet Ownership on Human Well-Being: Evaluating and Expanding Current Hypotheses
Authors: Barcelos Ana Maria , Kargas Niko , Maltby John , Mills Daniel S. 
Published: March 2023

AbstractThere is a set of hypotheses commonly used in the literature to explain how pets affect human well-being (e.g., pets as social catalysts). Many studies are reported as giving results consistent with one or more of these, but they may not appear to be sufficient to explain the impacts of several pet-related activities on owner well-being. Confirmation bias may also overshadow the consideration of alternative mechanisms. This report aims to review and evaluate a range of psychosocial hypotheses that might help to explain how pets affect the well-being of their owners. This included a theoretical testing of the hypotheses against the recurring themes which emerged from four previously published qualitative frameworks relating to pet-related activities and their well-being outcomes. Twelve psychosocial hypotheses were generated and evaluated using this process: (1) social catalyst-repellent, (2) emotional contagion and empathy, (3) social support, (4) biophilia, (5) attributed fault, (6) social norms, (7) annoyance by noises, (8) routine, (9) caring, (10) exercise, (11) learning, and (12) affective touch. Only three presented potentially contradictory evidence (i.e., social catalyst-repellent, routine, and caring hypotheses), but closer examination revealed that these could not be rejected. These twelve hypotheses are a source of reference for a broader consideration of how pets might affect human well-being. Researchers are encouraged to use, test and/or challenge these hypotheses using established methods of scientific falsification in order to identify which are of the most important in relation to specific owner well-being outcomes.
Research on high temperature performance of pressure sensor
Authors: Zhao Zhiqiang , Pan Shuliang , Memon Maria Muzamil , Liu Qiong , Wang Tao , Zhang Wanli 
Published: March 2023

Abstract
This work proposes a molybdenum (Mo) based pressure sensor capable of operating at temperatures higher than 300 °C. The sensor utilizes a 30 μm thick rectangular pressure-sensitive film and 2 μm thick gate Mo resistors to form a Wheatstone bridge structure to enhance pressure sensing. Finite element analysis (FEA) has been performed to design the sensor and analyze the pressure and temperature effect. The developed sensor with the excitation of 1 V voltage exhibits excellent performance characteristics at room temperature (25 °C), including a sensitivity of 0.05689 mV V−1 kPa−1, 0.15% full scale (FS) accuracy, a nonlinearity of 0.79% FS, and 0.02% FS repeatability. The thermal zero shift of −0.13% FS/°C is obtained in the 25 °C to 300 °C temperature range. The simulation findings illustrate that the thermal mismatch weakens the thermal zero shift by +0.012‰ FS/°C, while the deviation of the temperature coefficient of resistance (TCR) and initial resistivity (

ρ

T
0

) aggravate the thermal zero shift by −0.139% FS/°C. Among both, the deviation of

ρ

T
0

and TCR is the major contributor to thermal zero shift. Moreover, it was found that the Seebeck effect caused by the on-chip temperature gradient also affects the accuracy of the sensor. A temperature difference of 5.4 °C produces a thermoelectric potential of 37.95 μV equivalent to a pressure of 670 Pa loading on the chip. Besides, the response characteristics of the sensor at different temperature rates were investigated.
Frequency scanning interferometry based deformation monitoring system for the alignment of the FCC-ee machine detector interface
Authors: Watrelot Léonard , Sosin Mateusz , Durand Stéphane 
Published: March 2023

Abstract
In a particle accelerator, two particle beams are accelerated and collided at one or several physics detectors. The machine detector interface (MDI) is the place where the accelerator ring is linked to the physics detector. It is the area where the alignment requirements are the most stringent, and the MDI of the lepton version of the future circular collider (FCC-ee) is no exception. It will implement a complex design and alignment requirement for typical components in the MDI are of the order of 30 μm. Until now, no working solutions have been proposed for the alignment of such MDI. In this contribution, two different systems are studied: the Surveillance d’Ouvrages par Fibre Optique (Structural Monitoring by Optical Fibers, SOFO) and the in-lined multiplexed and distributed frequency scanning interferometry (FSI). Both systems allow individual and simultaneous distance measurements of multiple portions along a fiber, and a new system using the FSI technology is proposed for the alignment monitoring. Using a network of helical shaped fiber allows the measurement of deformations if a sufficient amount of fibers is placed on the cylinder. With a sensor measurement accuracy of 1 μm, 3D coordinates of points at the end of a 4 m long and 0.25 m radius cylinder (FCC-ee MDI dimensions) can be determined at an accuracy under 5 μm. This system will provide a link between the alignment of the final focusing quadrupoles and the rest of the machine.
Correlation properties of a one-dimensional repulsive Bose gas at finite temperature
Authors: De Rosi Giulia , Rota Riccardo , Astrakharchik Grigori E , Boronat Jordi 
Published: March 2023

Abstract
We present a comprehensive study shedding light on how thermal fluctuations affect correlations in a Bose gas with contact repulsive interactions in one spatial dimension. The pair correlation function, the static structure factor, and the one-body density matrix are calculated as a function of the interaction strength and temperature with the exact ab-initio Path Integral Monte Carlo method. We explore all possible gas regimes from weak to strong interactions and from low to high temperatures. We provide a detailed comparison with a number of theories, such as perturbative (Bogoliubov and decoherent classical), effective (Luttinger liquid) and exact (ground-state and thermal Bethe Ansatz) ones. Our Monte Carlo results exhibit an excellent agreement with the tractable limits and provide a fundamental benchmark for future observations which can be achieved in atomic gases, cavity quantum-electrodynamic and superconducting-circuit platforms.
A first-principles study of electronic, optical and thermoelectric properties of TlXF3 (X: Zn, Sr) perovskite crystal structure
Authors: Khan Sajid , Gassoumi Abdelaziz , Rahman Altaf Ur , Ullah Farhat , Ahmad Rashid , Mehmood Nasir , Abdul M , Shah Abdul Hakim 
Published: March 2023

Abstract
This study communicates the structural, electronic, optical, and thermoelectric properties of a perovskite TlXF3 (X: Zn, Sr) crystal structure using first-principles calculations. Both compounds were found structurally as well as thermodynamically stable in cubic phase. To check the kinetic stability, the phonon frequancy band structure is calculated which indicates that there is no negative frequency in the phonon spectrum, which confirms the dynamic stability of TlXF3. The bandgaps of both compounds belong to insulating region. The TlSrF3 exhibits direct bandgap of 4.37 eV at X symmetry point while TlZnF3 possess indirect bandgap of 3.95 eV (M-X). Using HSE functional, the calculated electronic bandgaps of TlSrF3 and TlZnF3 are 5.74 eV(X-X) and 5.36 eV (M-X), respectively. The analysis of electronic states in band structure shows that for TlSrF3, the top of valence band is composed of the F-p states whereas the states in lower potion of conduction band are impacted by the significant contribution of Tl-p orbital states. In case of TlZnF3, the states near the valence band maxima and conduction band minima are coming mainly form Tl atom. The effect of spin–orbit coupling (SOC) on the electronic band structure is also considered. The SOC in the valance band is negligible, while in the conduction band it shows a dominant effect at Γ-point in both TlSrF3 and TlZnF3 compounds. The dependence of thermoelectric properties such as electrical conductivity σ, Seebeck coefficient (S), Power factor (PF), electronic thermal conductivity (κ) and figure-of-merit (ZT) as a function of carrier concentration and temperature are investigated. The optical properties were also studied to understand the response of TlXF3 to incident photons of energies upto 14 eV. We conclude that the TlXF3 are promising candidates for electronic, thermoelectric and optoelectronic devices.
Characterization of the absorption properties of 5 nm spherical gold nanoparticles functionalized with dodecanothiol and without functionalization with potential therapeutic applications
Authors: Cruz-Rodríguez Juan C , Camacho-López Miguel A , Torres-García Eugenio , Aranda-Lara Liliana , Morales-Avila Enrique , Díaz-Sánchez Luis E , Jiménez-Mancilla Nallely P , Isaac-Olivé Keila 
Published: March 2023

Abstract
Hybrid nanosystems have useful properties for preparing therapeutic systems. Among the most commonly used inorganic components in hybrid nanosystems are gold nanoparticles (AuNP). The design of these nanosystems may require AuNP of hydrophilic or hydrophobic nature. Upon irradiation of AuNP, reactive oxygen species (ROS) are formed, and the temperature of the surrounding medium rises, depending on the size, shape and structure of the nanoparticle. The aim of this work is to evaluate whether irradiating 5 nm spherical gold nanoparticles both ‘bare’ (AuNP) and functionalized with dodecanethiol (AuNPf) with a Nd:YAG pulsed laser (30 ps, and 10 Hz) at wavelengths of 532 nm (0.031 J cm−2) and 1064 nm (1.91 J cm−2) produces ROS and heat sufficiently to induce cytotoxicity, or to demonstrate whether functionalization significantly influences such processes. It was verified by UV–vis spectrophotometry with ABMA and DCPIP that AuNP and AuNPf in solution induced ROS formation. They also produce a moderate elevation of the temperature of the surrounding medium. Irradiation of T47D cells at 532 nm in the presence of AuNP significantly decreased cell viability (>60%) compared to irradiation in the absence of NP (<20%). This effect was less evident when irradiating at 1064 nm because the cytotoxicity in the absence of AuNPs was very high (80%). AuNPf showed in solution a similar behavior to AuNP but due to the solvent in the suspension it was not possible to evaluate the cell toxicity caused by AuNPf. The results obtained indicate that it is feasible to design hybrid nanosystems for therapy from these 5 nm NPs, which would have photodynamic and photothermal effect.
Analysis of the finite-size effect of the long-range Ising model under Glauber dynamics
Authors: Komatsu Hisato 
Published: March 2023

Abstract
We considered a long-range Ising model under Glauber dynamics and calculated the difference from the mean-field approximation in a finite-size system using perturbation theory. To deal with the Bogoliubov–Born–Green–Kirkwood–Yvon hierarchy, we assumed that certain types of extensive properties have a Gaussian distribution, which turned out to be equivalent to the Kirkwood superposition approximation within the range of first-order perturbation. After several calculations, ordinary differential equations that describe the time development of a two-body correlation were derived. This discussion is the generalization of our previous study which developed a similar consideration on the infinite-range Ising model. The results of the calculation fit those of the numerical simulations for the case in which the decay of the interaction was sufficiently slow; however, they exhibited different behaviors when the decay became rapid.
Adhocratic mechanisms of formation of innovative and creative directions for business entities development in conditions of transparency of economics
Authors: Chobitok V , Mnykh O , Brytskyi R , Us Yu 
Published: March 2023

Abstract
The article defines that at the present stage of innovative and creative directions of industrial development there are strict requirements for waste management processes in order to reduce energy and resource consumption, increase their efficiency and ensure environmental safety at the level of world standards in conditions of transparency of economics. Modern scientific and technological progress has brought innovations to humanity, which have provided material resources for the accelerated development of society, as well as raised the question concerning the crisis of the use of limited resources and the emergence of environmental crises. The current status quo requires the production of adhocratic mechanisms for the formation of innovative and creative directions of development of economic entities in the conditions of transparency of economics to overcome this crisis in order to create a model of sustainable development. In this article the world practice of waste management and the current status quo of development of the system of waste formation and management in Ukraine for 2010-2020 have been analyzed. Using calculations of Chuprov, Cramer and Pearson coefficients, it has been determined that the correlation between the amount of waste formed and the amount of waste disposed in 2010-2020 in Ukraine is weak, which confirms the problem of waste management that needs to be addressed at different levels of management in conditions of transparency of economics. According to the results of the research, it has been suggested to develop and implement adhocratic mechanisms for the formation of innovative and creative directions of development of economic entities in conditions of transparency of economics.
The european green deal: shaping the future of the eastern partnership
Authors: Tsebenko Oleh , Ivasechko Olha , Turchyn Yaryna , Lukach Nataliia 
Published: March 2023

Abstract
The article has focused on the European Green Deal [EGD], its goals, key tasks and components. Particular attention has been paid to the specifics of the implementation of the EGD in the partner countries of the Eastern Partnership [EaP]. The author’s approach to singling out clusters of the EaP countries on the integration of their green policies, taking into account the level of convergence of the EaP countries environmental and climate policies and the peculiarities of the implementation of the EGD, has been presented. The potential of the countries of the region in terms of readiness to switch to green energy has been identified on the basis of the Energy Transition Index and the dynamics of the EaP Environmental and Climate Policy Sub-Index. The degree of correlation between the general degree of convergence of the EaP countries to the European Union and the degree of convergence of the EaP countries environmental and climate policies to the EGD has been determined. The ways of transformation of the strategy of formation and implementation of the EGD for the Eastern Partnership countries, taking into account the current challenges, have been outlined. Thorough conclusions and recommendations for the EaP countries in the context of EGD implementation have been presented.
Modeling the sustainable development of the foreign economic activity of agricultural enterprises (case for Ukraine)
Authors: Boryshkevych I , Halas L , Yakubiv V , Hryhoruk I , Turala M 
Published: March 2023

Abstract
The level of any country’s involvement in foreign trade significantly influences its economic situation, primarily because it is a major channel of foreign exchange earnings. The development of agriculture in Ukraine is the basis for increasing the gross domestic product, as it provides jobs to a significant part of the population. The success of foreign economic activity of agricultural enterprises is primarily determined by their level of strategic competitive advantage in the world market. Making management decisions on foreign economic activity, according to the position of competitiveness of agricultural enterprises, is a rather complex process, which should be preceded by analysis and assessment. Building strategic competitive advantages of agricultural enterprises ensures the efficiency and effectiveness of their foreign economic activity. The article deals with a methodical approach to classifying agricultural enterprises in Ukraine according to the degree of foreign economic activity, which includes calculation of the regional index of export competitiveness of agricultural enterprises and their grouping by the degree of foreign economic activity. For grouping, we propose to use a simple method for one grouping feature at regular intervals. As a result, three groups of agricultural enterprises of the regions of Ukraine are singled out in accordance with the degree of development of the foreign economic activity, namely with a low, medium, and a high degree of development.