Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe
Authors: Haas Andreas D. , Kunzekwenyika Cordelia , Manzero Josphat , Hossmann Stefanie , Limacher Andreas , van Dijk Janneke H. , Manhibi Ronald , von Groote Per , Hobbins Michael A. , Verhey Ruth , Egger Matthias ,   Friendship Bench ART trial group, Kateta Amos , Mutonhodza Cuthbert , Machiha Favourite , Mhlanga Ntandoyenkosi , Matutururu Shingai , Gombwiro Tatenda , Gweredza Millicent , Saide Josephine Yasmin , Muchakubvura Beauty , Mhlanga Kudzai , Mwakasa Dennis , Zvekare Fungai Nyikadzino , Maumbe Yvonne Chiedza , Maposa Boldwin , Gumbo Sibongile , Kamusha Japhet , Tshuma Morris , Runyowa Rejoyce , Pikayi Abigail , Mbiba Fredrick , Mutungama Chiedza Elizabeth , Mukuwapasi Waraidzo AM , Mandabva Rudo , Trelle Sven , Manda Ethel , Majichi Duncan Tatenda 
Published: July 2023

ImportanceCommon mental disorders (CMD), which include depression and anxiety, are prevalent among people living with HIV and are associated with suboptimal antiretroviral therapy (ART) adherence.ObjectiveTo assess the effect of a lay health worker–led psychological intervention on ART adherence, virologic suppression, and mental health symptoms.Design, Setting, and ParticipantsOpen-label pragmatic cluster trial with 1:1 block randomization of 16 health facilities in rural Bikita, Zimbabwe. Recruitment occurred from October 2018 to December 2019, and participants were followed up for 12 months, ending in December 2020. Participants were adults aged 18 years and older, who spoke English or Shona, screened positive for CMD (Shona Symptoms Questionnaire [SSQ]-14 score ≥9), received first-line ART for 6 or more months, had no World Health Organization stage 4 disease, no psychosis, were not pregnant, and provided informed consent. Data were analyzed from March 2021 to February 2022.InterventionThe Friendship Bench, consisting of 6 lay health worker–led weekly problem-solving therapy sessions and optional peer-led group support.Main Outcomes and MeasuresThe primary outcome was mean adherence during 2 to 6 months of follow-up, and the secondary outcomes were mean adherence during 1 to 12 months of follow-up, change in SSQ-14 and Patient Health Questionnaire (PHQ-9) scores (3, 6, 9, and 12 months), and viral load suppression (6 and 12 months).ResultsA total of 516 participants were recruited (244 in Friendship Bench and 272 in enhanced standard care facilities); 438 (84.9%) were female and the mean (SD) age was 45.6 (10.9) years. Mean (SD) adherence between 2 to 6 months was 89.9% (18.4%) in the Friendship Bench group and 87.2% (20.1%) in the control group. The intervention had no statistically significant effect on adherence between 2 to 6 months (unadjusted mean difference, 1.93 percentage points; 95% CI, −1.20 to 5.06 percentage points; P = .23), between months 1 to 12 (mean difference 0.79 percentage points; 95% CI, −2.14 to 3.71 percentage points; P = .60), or viral suppression. Declines in SSQ-14 scores from baseline to 3 months (difference, −1.65; 95% CI, −3.07 to −0.24), 6 months (difference, −1.57; 95% CI, −2.98 to −0.15), and 9 months (difference, −1.63; 95% CI, −3.05 to −0.22) were greater in the Friendship Bench than the standard care group (P &amp;lt; .05). There were no differences in the decline in the SSQ-14 scores from baseline to 12 months and in declines in PHQ-9 scores from baseline to 3, 6, 9, and 12 months.Conclusions and RelevanceIn this randomized trial of HIV-positive participants with CMD, the Friendship Bench intervention had no effect on adherence and viral suppression, possibly due to the absence of skill-based adherence training and a ceiling effect.Trial RegistrationClinicalTrials.gov Identifier: NCT03704805