bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Non-academic Responsibilities of Teachers on Teaching Quality
Authors: Kulal Abhinandan , N Abhishek , Kanchan Swarn G , Kulal Meghashree 
Published: January 2023

Abstract
Teaching quality in an education system becomes the foundation and roadmap to the development of young people and country at large. If the quality of education declines the productivity of the country also declines. Whatever the type of education institutions running in the country must emphasize on improving the quality of education they are intended to provide. Nowadays it can be noticed that many education institutions are becoming commercial and mainly focusing on getting grades, certifications, rankings and recognitions. The purpose of presence study is to examine the impact of non-academic responsibilities on quality of teaching. For this purpose study adopted descriptive research design to analyse the collected data from the teachers teaching in higher education. This study observed that non-academic responsibilities are significantly influencing on teaching quality in India. Thus, the higher education institutions and regulators should work together to bring policies, strategies and methods to balance both academic and non-academic responsibilities without compromising with the teaching quality. If this will be the reality the competencies of the students for their survival will be enhanced and in turn the overall productivity of young people will also go up for the long run.
Childhood trauma and depressive level among non-clinical Chinese college students: the roles of rumination and perceived stress
Authors: Wang Junjing , Liang Qian , Ma Yueqi , Zhang Yi 
Published: January 2023

Abstract
Background: Childhood trauma is one of major risk factors to depression, and the incidence of depression among college students has been increasing. Previous studies have validated the effect of childhood trauma on depressive level. But few studies based on the Diathesis-stress theory to investigate the role of perceived stress in the pathway between childhood trauma and depressive level, as well as considering the role of rumination.
Methods: We recruited 995 non-clinical Chinese college students and ask them to finish four self-report questionnaires, including Childhood Trauma Questionnaire-Short Form (CTQ-SF), Perceived Stress Scale (PSS), the 22-item Ruminative Responses Scale (RSS-22), and Beck Depression Scale-II (BDI-II). Then we conducted the multiple mediation analyses and multiple linear regression analyses.
Results: Results revealed that perceived stress played a mediation role between childhood trauma and depressive level, and rumination played a moderation role between childhood trauma and perceived stress and between childhood trauma and depressive level.
Limitations: This is a cross-sectional study and based on subjective reports of measures.
Conclusions: These findings provided multi-dimensional indications for reducing the effect of childhood trauma on depressive level in college students, which would help them to improve their mental health.
Three Gorges Dam: The changing trend of the density of Oncomelania hupensis, the intermediate host for Schistosoma japonicum, in reaches of the Yangtze River, 1990-2019
Authors: Gong Yanfeng , Tong Yixin , Jiang Honglin , Xu Ning , Yin Jiangfan , Wang Jiamin , Huang Junhui , Chen Yue , Jiang Qingwu , Zhou Xiaonong , Li Shizhu , Zhou Yi-Biao 
Published: January 2023

Abstract
Background:
Oncomelania hupensis (O. hupensis) snail is the sole intermediate host of Schistosoma japonicum. Environmental changes caused by Three Gorges Dam (TGD), flood and drought, affect the distribution of snail population, and better understanding the dynamics and spatial distribution of snail density is critical for schistosomiasis risk assessment and control for affected areas.
Methods:
Data of O. hupensis snail survey between 1990 and 2019 were collected from previous studies in four electronic databases (CNKI, Wanfang, Pubmed, and SCI) and from the national schistosomiasis surveillance. Meta-analysis was conducted to estimate the overall and annual snail densities and their 95% confidence intervals (CIs). Joinpoint model was used to identify the changing trend and inflection point of snail density between 1990 and 2019. Inverse distance weighted (IDW) interpolation was used to determine the spatial distribution of recent snail density.
Results:
A total of 3777 snail survey sites (872 for the upstream area and 2905 for the downstream area of the TGD) with a precise location of village or beach were identified. For the downstream area of the TGD, the snail density peaked in 1998 (1.635/0.11m2, 95% CI: 1.220–2.189) and fluctuated at a relatively high level before 2003, and declined steadily from 2003 (1.143/0.11m2, 95% CI: 0.905–1.397) to 2012 (0.127/0.11m2, 95% CI: 0.081–0.199). The snail density maintained lower than 0.150/0.11m2 between 2012 and 2019. Joinpoint model identified that the inflection point of 2003 was statistically significant and the snail density showed a significant downward trend from 2003 to 2012 with an APC of -20.56% (95% CI: -24.15 to -16.80). For the Upstream area of the TGD, the snail density peaked in 2005 (0.760/0.11m2, 95% CI: 0.479–1.207) and was generally greater than 0.300/0.11m2 before 2005. The snail density steadily declined since 2006 and was generally lower than 0.150/0.11m2 after 2011. No inflection point was identified and the snail density showed a significant downward trend from 1990 to 2019 with an APC of -6.05% (95% CI: -7.97 to -7.09). The areas with a relatively high snail density were mainly distributed in Poyang Lake, Dongting Lake, Jianghan Plain, and the Anhui branch of the Yangtze River.
Conclusion:
The density of O. hupensis snails showed a fluctuating downward trend in the Yangtze River basin between 1990 and 2019. In the downstream area, the decline of snail density was accelerated after the operation of TGD, and then fluctuated at a relatively low level. Infected areas with a higher density of snails were distributed in Dongting Lake, Poyang Lake, Jianhan Plain, and the Anhui branch of the Yangtze River.
Nonagenarians Admission and Prognosis in a Tertiary Center Intensive Coronary Care Unit – a prospective study.
Authors: Bruoha Sharon , Maller Tomer , Loutati Ranel , Perel Nimrod , Tabi Meir , Taha Louay , Yosefy Chaim , Jafari Jamal , Braver Omri , Amsalem Itszhak , Hitter Rafael , Manassra Mohamed , Levy Nir , Abu-Alkean Ismael , Hamyil Kamal , Steinmetz Yoed , Karameh Hani , Karmi Mohamed , Marmor David , Wolak Arik , Glikson Michael , Asher Elad 
Published: January 2023

Abstract
Background
With increasing life expectancy, the prevalence of nonagenarians with cardiovascular disease is steadily growing. However, this population is underrepresented in randomized trials and thus poorly defined, with little quality evidence to support and guide optimal management. The aim of the present study was to evaluate the clinical management, therapeutic approach, and outcomes of nonagenarians admitted to a tertiary care center intensive coronary care unit (ICCU).
Methods
We prospectively collected all patients admitted to a tertiary care center ICCU between July 2019 – July 2022 and compared nonagenarians to all other patients. The primary outcome was in-hospital mortality.
Results
A total of 3807 patients were included in the study. Of them 178 (4.7%) were nonagenarians and 93 (52%) females. Each year the prevalence of nonagenarians has increased from 4.0% in 2019, to 4.2% in 2020, 4.6% in 2021 and 5.3% in 2022. Admission causes were similar in both groups except for a lower rate of ST segment myocardial infarction (STEMI) (12.9% vs. 27.3%, p < 0.001) and a higher rate of septic shock (4.5% vs 1.2%, p < 0.001) in nonagenarians. Nonagenarians had more comorbidities, such as hypertension, renal failure, and atrial fibrillation (82% vs. 59.6%, 23% vs. 12.9%, 30.3% vs 14.4% p < 0.001, respectively). In-hospital mortality rate was 2-fold higher in the nonagenarians (5.6% vs. 2.5%, p = 0.025).
Conclusions
With increasing life expectancy, the prevalence of nonagenarians in ICCU’s is expected to increase. Although nonagenarian patients had more comorbidities and higher in-hospital mortality, they generally have good outcomes after admission to the ICCU. Hence, further studies to create evidence-based practices and to support and guide optimal management in these patients are warranted.
Spreading Points using Gradient and Tabu
Authors: Huang Xiangyang , Huang LiGuo 
Published: January 2023

Abstract
Large spreading (packing) problems are hard to be solved exactly. Consequently, heuristic approaches are usually used to find approximate solutions. In this paper, a hybrid heuristic method, consisting of a Neighborhood Tabu (NT) and a Perturbed Gradient (PG), is proposed for solving spreading points problems. NT applies an adaptive random technique to selecting promising candidate solutions from the neighborhood of the current local minimum and PG uses a neighborhood-based perturbed gradient algorithm to seek a better minimum, starting from the candidates. Two procedures work alternatively and cooperatively. When applied to some previously studied packings, the proposed method can improve the accuracy of the previous record solutions.
Survival and neurologic outcomes following aortic occlusion for trauma and hemorrhagic shock in a hybrid operating room
Authors: Balch Jeremy A. , Loftus Tyler J. , Efron Philip A. , Mohr Alicia M. , Upchurch Gilbert R. , Smith R. Stephen 
Published: January 2023

Abstract
Background: Outcomes following aortic occlusion for trauma and hemorrhagic shock are poor, leading some to question the clinical utility of aortic occlusion in this setting. This study evaluates neurologically intact survival following resuscitative endovascular balloon occlusion of the aorta (REBOA) vs. resuscitative thoracotomy at a center with a dedicated trauma hybrid operating room with angiographic capabilities.
Methods: This retrospective cohort analysis compared patients who underwent zone 1 aortic occlusion via resuscitative thoracotomy (n=13) vs. REBOA (n=13) for blunt or non-thoracic, penetrating trauma and refractory hemorrhagic shock (systolic blood pressure less than 90 mmHg despite volume resuscitation) at a level 1 trauma center with a dedicated, trauma hybrid operating room. The primary outcome was survival to hospital discharge. The secondary outcome was neurologic status at hospital discharge, assessed by Glasgow Coma Scale (GCS) scores.
Results: Overall median age was 40 years, 27% had penetrating injuries, and 23% had pre-hospital closed-chest cardiopulmonary resuscitation. In both cohorts, median Injury Severity Scores and head Abbreviated Injury Scores were 26 and 2, respectively. The resuscitative thoracotomy cohort had lower systolic blood pressure on arrival (0 [0-75] vs. 76 [65-99], p=0.009). Hemorrhage control (systolic blood pressure 100 mmHg without ongoing vasopressor or transfusion requirements) was obtained in 77% of all REBOA cases and 8% of all resuscitative thoracotomy cases (p=0.001). Survival to hospital discharge was greater in the REBOA cohort (54% vs. 8%, p=0.030), as was discharge with GCS 15 (46% vs. 0%, p=0.015).
Conclusions: Among patients undergoing aortic occlusion for blunt or non-thoracic, penetrating trauma and refractory hemorrhagic shock at a center with a dedicated, trauma hybrid operating room, nearly half of all patients managed with REBOA had neurologically intact survival. The high death rate in resuscitative thoracotomy and differences in patient cohorts limit direct comparison.
Potential of patellar height measurement methods in predicting recurrent patellar dislocation incidence: A case-control study
Authors: Yamashita Satoshi , Ishizuka Shinya , Sakai Tadahiro , Oba Hiroki , Sakaguchi Takefumi , Mizuno Takafumi , Kawashima Itaru , Tsukahara Takashi , Takahashi Shigeo , Kurokouchi Kazutoshi , Imagama Shiro 
Published: January 2023

Abstract
Background
Recurrent patellar dislocation (RPD) is a multifactorial disease that affects young and active people. Patellar height measurements are used clinically to screen and diagnose knee conditions. However, there are no known studies that have assessed and compared the performance of patellar height indices for predicting the incidence of RPD, which could be used to recommend surgical treatment after primary patellar dislocation. This case-control study aimed to determine if the patellar height index could be used to predict the incidence of RPD, and to identify the optimal method in terms of its diagnostic ability for RPD.
Method
Altogether, 133 patients (52 patients with RPD [Group R] and 81 sex- and age-matched controls [Group C]) were enrolled in this study. The Insall-Salvati (IS), Blackburne-Peel (BP), Caton-Deschamps (CD), and modified IS (mIS) methods were used to measure the patellar height index. The intra-observer and inter-observer reliabilities of these four methods were determined using intraclass correlation coefficients. A receiver operating characteristic curve analysis was performed to evaluate the predictive ability of each index and identify the cut-off values that indicated significantly increased risk of RPD.
Results
Patient demographics were similar between the two groups. The inter-observer and intra-observer reliabilities were good for all four methods. In patients with RPD, the mean index values for the four methods were significantly higher than those in the matched controls. The area under the curve (AUC) values for IS, BP, CD, and mIS were 0.91 (standard error [SE], 0.03; 95% confidence interval [CI], 0.84–0.96), 0.72 (SE, 0.05; 95% CI, 0.63–0.81), 0.86 (SE, 0.03; 95% CI, 0.79–0.92), and 0.96 (SE, 0.01; 95% CI, 0.94–0.99), respectively.
Conclusion
Patellar height indices had high predictive performance for the incidence of RPD. The mIS method had the highest AUC.
Crestal sinus lift combining recombinant human bone morphogenetic protein-2 with leukocyte- and platelet- rich fibrin as grafting material: A 1-year retrospective pilot trial
Authors: He Dongning , 杨 扬 , Xu Linkun , Li Yi , Gao Wen , Wang Yi , Xue Lijun , Yu Feiyan 
Published: January 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Complete Recovery in NORSE Observed in İntensive Care Unit: A Case Report
Authors: Arıoğlu İnal Bensu , Koltka Emine Nursen 
Published: January 2023

Abstract
New-onset refractory status epilepticus (NORSE) is a definition used to describe clinical conditions with no history of seizures, no identifiable structural or etiological cause, and for which a diagnostic result cannot be reached by research. Its treatment is often done with intravenous anesthetic drugs and its mortality is quite high. In this article, a 33-year-old patient whose etiology could not be determined as a result of extensive research in our intensive care unit and who recovered completely is presented.
PLGA/BGP/Nef Porous Composite Restrains Osteoclasts by Inhibiting the NF-κB Pathway, Enhances IGF-1-mediated Osteogenic Differentiation and Promotes Bone Regeneration
Authors: Wu Feng , Wu Zhenxu , Ye Zhijun , Niu Guoqing , Ma Zhiliang , Zhang Peibiao 
Published: January 2023

Abstract
Background
Novel bone substitutes are urgently needed in experimental research and clinical orthopaedic applications. There are many traditional Chinese medicines that have effects on bone repair. However, application of natural medicines in traditional Chinese medicine to bone tissue engineering and its mechanism were rarely reported.
Results
In this study, the drug loading and controlled release ability and osteogenic ability of bioactive glass particles (BGPs) and the osteogenic and osteoclastic ability of neferine were fused into PLGA-based bone tissue engineering materials for bone regeneration. BGPs were prepared by spray drying and calcination for loading of Nef. Particles loaded with drugs were then mixed with PLGA solution to prepare porous composites by the phase conversion method. Here we showed that Nef inhibited proliferation and enhanced ALP activity of MC-T3-E1 cells in a dose- and time‐dependent manner. And the composites containing Nef could also inhibit RANKL‐induced osteoclast formation (p < 0.05). Mechanistically, the PLGA/BGP/Nef composite downregulated the expression of NFATC1 by inhibiting the NF-κB pathway to restrain osteoclasts. In the other hands, PLGA/BGP/Nef composite was first demonstrated to effectively activate the IGF-1R/PI3K/AKT/mTOR pathway to enhance IGF-1-mediated osteogenic differentiation. The results of animal experiments show that the material can effectively promote the formation and maturation of new bone in the skull defect site.
Conclusions
The PLGA/BGP/Nef porous composite can restrain osteoclasts by inhibiting the NF-κB pathway, enhance IGF-1-mediated osteogenic differentiation and promotes bone regeneration, and has the potential for clinical application.
Innovation Strategy Design of Public Sports Service Governance Based on cloud computing
Authors: Hao Yangyang , Qiu Zhaoyi , Xu Qiner , He Qiuhong , Fang Xuemo , Wang Chuyun 
Published: January 2023

Abstract
Public sports services are an important part of the service system of modern government construction, and play an important role in strengthening national physique, improving people's satisfaction with public services, and improving people's welfare level. With the implementation of the national sports strategy, the quality of sports is constantly improving, and significant progress has been made in sports facilities construction, sports services mechanism, sports services projects, sports services personnel, etc. Although the public sports services has made rapid progress, due to the tilt of the national development center and the difference in regional economic level, there are problems such as unbalanced urban and rural development, insufficient social security, etc. Therefore, this paper analyzed the characteristics of public sports services, the importance of development, the status quo and the causes of the status quo to study the problems in the current public sports services. According to the problems, the governance objectives and principles of sports services are constructed, and finally the innovation strategy of sports services is combined with cloud computing. It can be seen from edge computing that the update weight and the offset vector under the public sports services innovation strategy are gradually increasing over time. The average value of the update weight under the public sports services innovation strategy was about 1.28, and the average value of the offset vector was about 1.36. On the whole, the update weight under the public sports services innovation strategy increased by 0.33 in the whole process, while the offset vector increased by 0.34 in the whole process. The service quality and implementation effect of the cloud computing public sports service innovation system are better than the original public sports service system. The service quality of the cloud computing public sports service innovation system is about 10.6% higher than the original public sports service system, and the implementation effect is about 8.1% higher than the original public sports service system. In short, both cloud computing and intelligent models can promote the development of sports services.
Role of Hypertension and Obesity as Risk Factors for IHD
Authors: Ghaffari Mohammad Mujtaba. , Ahmadi Abdul Samad 
Published: January 2023

Abstract

Background
Hypertension and obesity are two major modifiable risk factors for CAD, most of the time there will be more than two risk factors in an IHD. Obesity itself cause insulin resistance to initiate type − 2 DM. is the most common and significant RFs for IHD, and proper BP management is the cornerstone of both direct and indirect prevention. Overweight and obesity account for more than 80% of CHD patients. Obesity is sometimes viewed as a "minor" CHD RF, however it is a widely effective risk-factor approach. A range of "major" risk factors have been proven to be significantly influenced by weight loss, including HTN, hyperlipidemia and insulin resistance/T2DM.
Aim
To assess arterial hypertension and obesity as risk factors of IHD.
Methods
This cross sectional study which was done retrospectively by collecting data from database of "Scientific Research Institute of Cardiology and Internal Diseases" Almaty city, Kazakhstan during 2020. IHD confirmed by history,physical exam, angiography and other lab findings.
Result
The research involved a total of 649 participants. The mean age of study population was 64.2 ± 9.24 (P = 0,000).Mean of SBP and DBP were 180.73 ± 34.9; 99.48 ± 14.28 mmHg respectively. Number of female with normal BMI 50(21.6%), overweight 93(40.10%), obesity class – 1, 59(25.4%), obesity class – 2, 23(9.90%) and obesity class – 3, 7(3%), (P = 0.486). Number of male with underweight BMI 1(0.20%), normal BMI 96(23%), overweight 190(45.6%), obesity class – 1, 89(21.3%), obesity class – 2, 29(7%) and obesity class – 3, 12(2.9%). (P = 0.486). Mean of BMI in both gender was (28.72 ± 11.79).
Conclusion
The burden of CVDs and their related risk factors is significant in Almaty, posing a major public health concern. For accurate management and implementation of preventive measures in this area, effective strategies in management, education, and healthcare centers are needed.
METTL3-mediated m6A modification of lncRNA TSPAN12 promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma through SENP1-dependent deSUMOylation of EIF3I
Authors: Li Bei , Xiong Xianze , Xu Jianrong , Peng Dingzhong , Nie Guilin , Wen Ningyuan , Wang Yaoqun , Lu Jiong 
Published: January 2023

AbstractBackground Our previous study revealed that lnc-TSPAN12 was remarkably upregulated in HCC and correlated with poor survival. However, the role of lnc-TSPAN12 in regulating epithelial-mesenchymal transition (EMT) and metastasis in hepatocellular carcinoma (HCC) remains uncharacterized. Methods The biological function of lnc-TSPAN12 in HCC metastasis was investigated by loss- and gain-of-function experiments both in vitro and in vivo. RNA pull-down, RNA immunoprecipitation and fluorescence in situ hybridisation were performed to examine the interaction between lnc-TSPAN12 and Eukaryotic Translation Initiation Factor 3 subunit I (EIF3I)/Sentrin/SUMO-Specific Protease 1 (SENP1) (SUMO: small ubiquitin-like modifier). EIF3I ubiquitination and SUMOylation modifications were analyzed using co-immunoprecipitation and western blot. Results Functional assays showed that lnc-TSPAN12 positively regulated the migration, invasion and EMT of HCC cells in vitro and accelerated liver metastasis in patient-derived tumour xenograft metastasis models in vivo. Importantly, methyltransferase like 3 (METTL3) mediated N6-methyladenosine modification is responsible for the upregulation of lnc-TSPAN12, contributing to lnc-TSPAN12 stabilization. Mechanistically, lnc-TSPAN12 physically interacts with EIF3I/SENP1 and functions as a scaffold to facilitate the binding of SENP1 to EIF3I, which suppresses EIF3I SUMOylation and ubiquitin degradation, ultimately activating Wnt/β-catenin signalling to promote EMT and metastasis in HCC. Conclusions Our findings elucidate the regulatory mechanism of lnc-TSPAN12 involved in metastasis of HCC and highlight the lnc-TSPAN12-EIF3I/SENP1 axis as a promising therapeutic target for the disease.