bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction of Tumor Ferroptosis‐Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel
Authors: Dai Xiaomeng , Zhang Jia , Bao Xuanwen , Guo Yixuan , Jin Yuzhi , Yang Chenjing , Zhang Hangyu , Liu Lulu , Gao Yang , Ye Chanqi , Wu Wei , Liu Chuan , Zhao Chun‐Xia , Sheng Jianpeng , Ren En , Li Hongjun , Fang Weijia , Wu Baiheng , Ruan Jian , Gu Zhen , Chen Dong , Zhao Peng 
Published: May 2023

AbstractThe combination of ferroptosis inducers and immune checkpoint blockade can enhance antitumor effects. However, the efficacy in tumors with low immunogenicity requires further investigation. In this work, a water‐in‐oil Pickering emulsion gel is developed to deliver (1S, 3R)‐RSL‐3 (RSL‐3), a ferroptosis inducer dissolved in iodized oil, and programmed death‐1 (PD‐1) antibody, the most commonly used immune checkpoint inhibitor dissolved in water, with optimal characteristics (RSL‐3 + PD‐1@gel). Tumor lipase degrades the continuous oil phase, which results in the slow release of RSL‐3 and PD‐1 antibody and a notable antitumor effect against low‐immunogenic hepatocellular carcinoma and pancreatic cancer. Intriguingly, the RSL‐3 + PD‐1@gel induces ferroptosis of tumor cells, resulting in antitumor immune response via accumulation of helper T lymphocyte cells and cytotoxic T cells. Additionally, the single‐cell sequence profiling analysis during tumor treatment reveals the induction of ferroptosis in tumor cells together with strong antitumor immune response in ascites.
Patterned Laser Ablation of Microgrooves with Controllable Cross‐Sections
Authors: Qiu Pei , Guo Yang , Huang Lingyu , Li Jun , Huang Jiaxu , Wang Min , Zhang Zhiyu , Xu Shaolin 
Published: May 2023

AbstractFabricating precision microgrooves with controllable cross‐sections on difficult‐to‐machine materials is significantly valuable but still challenging. Herein, a patterned laser‐induced microjet‐assisted ablation method for cross‐sectional profiles controllable laser micromachining is proposed. During the liquid‐assisted laser ablation process, debris and bubbles that may disturb the laser energy deposition can be instantaneously expelled by a directional laser‐induced microjet. The Gaussian laser spot is spatially modulated into specific geometric shapes, such as triangles, to tune locally deposited laser energy to carve microgrooves with designed cross‐sections. To achieve customized microgrooves efficiently, a reliable geometrical model based on the ablation threshold theory is developed to guide the processing parameter selection, including the laser spot shape, polarization, pulse energy, and scanning strategies. The simulation and experimental results confirm that this method achieves the decoupled control of the groove depth and width in a single‐path laser ablation process. Using this method, the design and manufacturing of microgrooves with controllable cross‐sections on single crystalline silicon carbide are demonstrated. The patterned laser‐induced microjet‐assisted ablation method provides a new route for fabricating precision microgrooves with controllable cross‐sections on difficult‐to‐machine materials.
Photocatalytic Activity of TiO2‐Containing Nanocomposites versus the Chemical Nature of the Polymeric Matrices: A Comparison
Authors: Vento Fabiana , Nicosia Angelo , Mezzina Lidia , Raciti Giulia , Gulino Antonino , Condorelli Marcello , D'Urso Luisa , De Guidi Guido , Mineo Placido 
Published: May 2023

AbstractEnvironmental remediation of xenobiotic pollutants is an important issue in industrialized society. Catalyst‐mediated pollutant photodegradation using solar light shows promising results. Titanium dioxide nanoparticles (TiO2NPs) are a well‐known standard for mineralizing organic water pollutants. Its use as a sludge pointed out the need to support this photocatalyst to ease both its use and recovery. Polymers represent a viable solution because of their versatility, stability, and cheapness. The in situ radical bulk polymerization approach to the development of TiO2‐based thermoplastic nanocomposites for xenobiotic photodegradation enhances the photocatalytic performance of the semiconductor nanoparticles. The versatility and efficiency of these systems pave the way for their industrial applications as photocatalytic coatings for large‐scale surfaces. To shed light on the influences of the chemical nature of the polymer matrix on the photocatalytic efficiency of the nanosystems, polyvinyl acetate, polymethyl methacrylate, and polystyrene are investigated as supports for TiO2NPs. The obtained TiO2‐containing nanocomposites are characterized by thermal analyses, UV‐vis, Raman, and X‐ray photoelectron spectroscopies, dynamic light scattering, and contact angle measurements. The photocatalytic activity of the nanosystems in the form of thin films is investigated against pollutants in water solutions, and shows clear differences in the photodegradation efficiency among the nanocomposites having different chemical natures of polymers.
Manganese‐Mediated Reductive Alkylation of Thiazolyl‐Phosphonium Salts
Authors: Yang Mengwan , Fang Jiaxi , Liu Huan , Lu Xinyao , Zhou Jiawen , Mou Zehuai , Wang Huifei 
Published: May 2023

AbstractReductive functionalization reactions between two electrophiles is a straightforward protocol to access carbon‐carbon bonds without use of organometallic reagents prepared in advance. Here, we developed a manganese‐mediated reductive alkylation of heterocyclic thiazolyl‐phosphonium salts with benzyl bromides to form C2‐alkylated benzothiazoles. The reaction features a broad substrate scope, high‐functional‐group tolerance, and can be utilized in late‐stage modification of complex natural products and bioactive molecules.
Fluoroalkyl Iodides in Fluoroalkylative Difunctionalization of C−C Multiple Bonds
Authors: Lucio‐Martínez Fátima , Chaładaj Wojciech 
Published: May 2023

AbstractFluorinated alkyl iodides serve as a convenient and inexpensive source of fluoroalkyl radicals that can readily undergo addition to the C−C unsaturated bonds of alkynes and alkenes which is the foundation for a variety of useful synthetic protocols. Since 2010 this field has witnessed huge progress in several respects. First the portfolio of fluorinated alkyl iodides was extended beyond only simple perfluoroalkyl iodides (CnF2n+1I). In particular, employment of iododifluoro−methyl‐ carbonyls and phosphonates has enabled facile installation of the medicinally relevant difluoromethylene motif. Secondly, from a conceptual point of view, novel strategies for activation of fluoroalkyl iodides towards radical formation have been introduced, relying on the formation of electron donor‐acceptor (EDA) complexes, photoredox catalysis, frustrated Lewis pairs and transition metal catalysis, complementing prior approaches based on heat and UV induced C−I homolysis, radical initiators, and simple electron transfer processes. Based on these strategies a range of novel fluoroalkylative transformations of unsaturated systems have been added to classical iodoperfluoroalkylation. Broadly applicable protocols for simple fluoroalkylation and hydrofluoroalkylation, as well as for more sophisticated, complexity‐building methods of fluoroalkylation‐annulation and tandem multicomponent fluoroalkylations with concomitant installation of another functionality have been recently disclosed. This review summarizes the progress achieved since 2010 in the reactivity of fluoroalkyl iodides towards alkenes and alkynes with emphasis placed on the above‐mentioned advances.
Size‐Controlled DNA Tile Self‐Assembly Nanostructures Through Caveolae‐Mediated Endocytosis for Signal‐Amplified Imaging of MicroRNAs in Living Cells
Authors: Peng Yanan , Gao Zhijun , Qiao Bin , Li Dongxia , Pang Huajie , Lai Xiangde , Pu Qiumei , Zhang Rui , Zhao Xuan , Zhao Guangyuan , Xu Dan , Wang Yuanyuan , Ji Yuxiang , Pei Hua , Wu Qiang 
Published: May 2023

AbstractSignal‐amplified imaging of microRNAs (miRNAs) is a promising strategy at the single‐cell level because liquid biopsy fails to reflect real‐time dynamic miRNA levels. However, the internalization pathways for available conventional vectors predominantly involve endo‐lysosomes, showing nonideal cytoplasmic delivery efficiency. In this study, size‐controlled 9‐tile nanoarrays are designed and constructed by integrating catalytic hairpin assembly (CHA) with DNA tile self‐assembly technology to achieve caveolae‐mediated endocytosis for the amplified imaging of miRNAs in a complex intracellular environment. Compared with classical CHA, the 9‐tile nanoarrays possess high sensitivity and specificity for miRNAs, achieve excellent internalization efficiency by caveolar endocytosis, bypassing lysosomal traps, and exhibit more powerful signal‐amplified imaging of intracellular miRNAs. Because of their excellent safety, physiological stability, and highly efficient cytoplasmic delivery, the 9‐tile nanoarrays can realize real‐time amplified monitoring of miRNAs in various tumor and identical cells of different periods, and imaging effects are consistent with the actual expression levels of miRNAs, ultimately demonstrating their feasibility and capacity. This strategy provides a high‐potential delivery pathway for cell imaging and targeted delivery, simultaneously offering a meaningful reference for the application of DNA tile self‐assembly technology in relevant fundamental research and medical diagnostics.
Profit and viability persistence: Evidence from the Spanish agricultural sector
Authors: Gómez‐Limón José A. , Sánchez‐Cañizares Sandra , Hidalgo‐Fernández Amalia , Castillo‐Canalejo Ana M. 
Published: May 2023

AbstractThe literature focused on analyzing profit persistence in the agricultural sector is scarce. This paper contributes to reducing this gap by carrying out an empirical study of 10 types of farming in Spain based on a dynamic panel model with microeconomic data from a large sample of farms provided by the Spanish Farm Accountancy Data Network. The generalized method of moments system estimator is used to assess profit persistence, including all significant lagged profit rates explaining the adjustment of abnormal profits over time. Moreover, the dynamic of farms' economic performance is analyzed considering the return on assets as a dependent variable (i.e., measuring farms' profitability), as well as an alternative indicator that also accounts for opportunity costs (i.e., measuring farms' viability). The results show that profit and viability persistence in the farming sector are complex dynamic processes that depend on several lags of the aforementioned dependent variables (between 2 and 5 years), with high abnormal profit and viability persistence being widespread. In any case, heterogeneous persistence results are achieved depending on the type of farming. The differences found can be explained by disparities in several explanatory variables contributing to above‐ or below‐average performance. The conclusions reached could lead to sounder decision‐making regarding agricultural policy (i.e., farm subsidies) and competition policy (i.e., exceptions to competition law). [EconLit Citations: D41; L13; L22; L25; Q12; C23].
Current progress in perioperative chemotherapy for biliary tract cancer
Authors: Ioka Tatsuya , Shindo Yoshitaro , Ueno Makoto , Nagano Hiroaki 
Published: May 2023

AbstractBiliary tract cancer (BTCs) is a heterogeneous malignancy divided into cholangiocarcinoma, gallbladder cancer, and ampullary cancer. Due to little or no symptoms, most patients with BTCs are diagnosed with unresectable or metastatic disease. Only 20%–30% of all BTCs are suitable for potentially resectable diseases. Although radical resection with a negative surgical margin is the only potentially curative method for BTCs, most patients develop postoperative recurrence, which is associated with poor prognosis. Therefore, perioperative treatment is necessary to improve survival. There are very few randomized phase III clinical trials of perioperative chemotherapy due to the relative rarity of BTCs. Adjuvant chemotherapy with S‐1 for patients with resected BTC significantly increased overall survival compared with upfront surgery in a recent ASCOT trial. In East Asia, S‐1 is currently considered the standard adjuvant chemotherapy, while capecitabine may still be used in other areas. Since then, our phase III trial (KHBO1401), gemcitabine and cisplatin plus S‐1 (GCS) has become the standard chemotherapy for advanced BTCs. GCS not only improved overall survival but demonstrated a high response rate. The efficacy of GCS as a preoperative neoadjuvant chemotherapy for resectable BTCs has been investigated in a randomized phase III trial (JCOG1920) in Japan. In this review, we summarize the current and ongoing clinical trials focusing on adjuvant and neoadjuvant chemotherapy for BTCs.
Effect of Intercalated LiF on Interface Contact Characteristics of MoS2 Field Effect Transistor: A First‐Principles Study
Authors: Hou Weimin , Chen Li , Yang Maoyou , Zhang Mingjian , Wang Junmei , Shi Jiakuo , Su Shuo , Zhang Duo , Wu Hongping 
Published: May 2023

AbstractBased on the first‐principles calculation, the effect of intercalated LiF on the contact characteristics of the interface between Au electrode and MoS2 layer is studied. It is found that adding LiF film can change the contact type between metal electrode Au and MoS2 layer from Schottky contact to ohmic contact, which is accompanied by interfacial charge transfer from LiF layer to MoS2 layer and the downward movement of d (dxy and dz2) orbital of Mo atom and p (px and py) orbital of S atom to Fermi level. And the interlayer spacing between LiF layer and Au electrode has a great impact on the interface contact characteristics. The electric field effect and stress effect of interface contact of Au, LiF and MoS2 (Au/LiF/MoS2)is more obvious than that of interface contact of Au and MoS2 (Au/MoS2). Au/LiF/MoS2 shows ohmic contact with the interlayer spacing between Au layer and LiF layer less than 3.05 Å and with the electric field less than 0.15 VÅ−1, respectively, while Au/MoS2 still shows N‐type Schottky contact. These findings are helpful to control the contact resistance and have guiding significance for high performance MoS2 field effect transistor and other electronic components.
A comparative assessment of the use of suitable analytical techniques to evaluate plasticizer compatibility
Authors: Burns Katharine , Potgieter Johannes H. , Potgieter‐Vermaak Sanja , Ingram Ian D. V. , Liauw Christopher M. 
Published: May 2023

AbstractThe evaluation of novel phthalate‐free plasticisers for PVC formulations is hindered by the lack of a reliable quantitative method for testing plasticizer exudation from PVC formulations. Two methods of improving upon the ASTM D3291 exudation test have been trialed using ATR‐FTIR and GC–MS. The results of these methods are compared alongside a study of the glass transition temperatures (Tg) by dynamic mechanical analysis (DMA). FTIR is found to be unsuitable for determining plasticizer exudation as the method is not sufficiently sensitive to detect small changes in plasticizer distribution. Carbonyl peak positions in unstressed samples are instead investigated to determine the strength of interaction between the plasticisers and PVC chain. GC–MS is successfully used to quantify plasticizer exudation that could not be observed visually or by FTIR. Furthermore, these methods show limited correlation to each other, which highlights the importance of testing multiple aspects of compatibility when developing novel plasticisers for use in PVC.
A frequentist approach to dynamic borrowing
Authors: Li Ruilin , Lin Ray , Huang Jiangeng , Tian Lu , Zhu Jiawen 
Published: May 2023

AbstractThere has been growing interest in leveraging external control data to augment a randomized control group data in clinical trials and enable more informative decision making. In recent years, the quality and availability of real‐world data have improved steadily as external controls. However, information borrowing by directly pooling such external controls with randomized controls may lead to biased estimates of the treatment effect. Dynamic borrowing methods under the Bayesian framework have been proposed to better control the false positive error. However, the numerical computation and, especially, parameter tuning, of those Bayesian dynamic borrowing methods remain a challenge in practice. In this paper, we present a frequentist interpretation of a Bayesian commensurate prior borrowing approach and describe intrinsic challenges associated with this method from the perspective of optimization. Motivated by this observation, we propose a new dynamic borrowing approach using adaptive lasso. The treatment effect estimate derived from this method follows a known asymptotic distribution, which can be used to construct confidence intervals and conduct hypothesis tests. The finite sample performance of the method is evaluated through extensive Monte Carlo simulations under different settings. We observed highly competitive performance of adaptive lasso compared to Bayesian approaches. Methods for selecting tuning parameters are also thoroughly discussed based on results from numerical studies and an illustration example.
Examining the mediating role of brand trust and brand commitment in fostering consumer perceptions toward recycled products
Authors: Singh Deeksha , Kunja Sambashiva Rao 
Published: May 2023

AbstractOver the past decade, there has been an upsurge in environmentally and socially conscious consumers. The paradigm shift toward sustainability has obligated businesses to understand the role of consumers' attitudes toward sustainability. This study examines the impact of brand attitude on the intent to purchase recycled products through brand trust and brand commitment. Prior research focused specifically on recycled products and luxury brands; thus, this study endeavors to examine consumer behavior from the perspective of non‐luxury brands within the context of recycling. In doing so, a sample of 333 Indian consumers was used to analyze the formulated hypothesis using mediation analysis in SPSS Process Macro. The findings exhibit that brand trust and brand commitment serve as mediators as well as serial mediators in the relationship between brand attitude and purchase intention toward recycled products. The study advances the literature on recycled products by combining two theories – theory of reasoned action and trust‐commitment theory, and by incorporating a branding perspective into the picture. Besides this, it helps marketers prioritize what is really important for a brand to gain trust and commitment from consumers in this competitive world.
The impact of ESG news on the volatility of the Portuguese stock market—Does it change during recessions?
Authors: Zanatto Cássio , Catalão‐Lopes Margarida , Pina Joaquim P. , Carrilho‐Nunes Inês 
Published: May 2023

AbstractThis paper assesses how environmental, social, and governance (ESG) news influence Portuguese stock market volatility depending on the business cycle. Given the lack of an adequate index to capture the effects of ESG media on the Portuguese stock market, a News Sentiment Index is developed. This index, which captures positive and negative ESG news on companies listed in the Portuguese Stock Index (PSI‐20), is then used as an external regressor in symmetric and asymmetric GARCH‐type models employed to model the stock market volatility. Results show that during non‐crisis periods ESG news reduce returns' volatility, and that when considering the period preceding the financial crisis the disclosure content (positive or negative) of the news matter. However, during economic downturns, neither the amount nor the content disclosure of ESG news affect volatility; thus, ESG preoccupations might no longer be paramount.
Spectrophotometric and Fluorimetric High‐Throughput Assays for Phenolic Acid Decarboxylase
Authors: Terholsen Henrik , Myrtollari Kamela , Larva Mirna , Möller Christina , Taden Andreas , Kourist Robert , Bornscheuer Uwe T. , Kracher Daniel 
Published: May 2023

AbstractBiocatalytic decarboxylation of hydroxycinnamic acids yields phenolic styrenes, which are important precursors for antioxidants, epoxy coatings, adhesives and other polymeric materials. Bacillus subtilis decarboxylase (BsPAD) is a cofactor‐independent enzyme that catalyzes the cleavage of carbon dioxide from p‐coumaric‐, caffeic‐, and ferulic acid with high catalytic efficiency. Real‐time spectroscopic assays for decarboxylase reactions remove the necessity of extensive sample workup, which is required for HPLC, mass spectrometry, gas chromatography, or NMR methods. This work presents two robust and sensitive assays based on photometry and fluorimetry that allow decarboxylation reactions to be followed with high sensitivity while avoiding product extraction and long analysis times. Optimized assay procedures were used to measure BsPAD activity in cell lysates and to determine the kinetic constants (KM and Vmax) of the purified enzyme for p‐coumaric‐, caffeic‐ and ferulic acid. Substrate inhibition was shown for caffeic acid.
Acute arthritis following SARS‐CoV‐2 infection: About two cases
Authors: Brahem Mouna , Jomaa Olfa , Arfa Sondess , Sarraj Rihab , Tekaya Rami , Berriche Olfa , Hachfi Haifa , Younes Mohamed 
Published: May 2023

Key Clinical MessageJoint involvement in COVID‐19 may occur at different stages of the disease and maybe represented by non‐specific arthralgia or by acute arthritis. We report two cases of COVID‐19 infection that were complicated by postviral reactive arthritis. Case 1: A 47‐year‐old male was presented 20 days after a COVID‐19 infection with acute right knee arthritis. On biologic data, erythrocyte sedimentation rate and C‐reactive protein were normal, and immunologic data were negative. A joint puncture was performed showing a turbid fluid. Testing for microcrystals was negative, as well as the synovial fluid culture. An infectious investigation was conducted, which was negative. The patient's complaints improved significantly, with analgesics and non‐steroidal anti‐inflammatory drugs (NSAID). Case 2: A 33‐year‐old female presented with acute left knee arthritis evolving for 48 h, free of fever, after a COVID‐19 infection treated 15 days ago. On examination, besides knee arthritis, the osteoarticular examination was normal. A biological inflammatory syndrome was noted in laboratory tests. A yellow fluid with multiple PNN was detected in the joint fluid aspiration, with a negative culture. The patient was treated by analgesics and NSAID. The follow‐up was highlighted by the arthritis resolution. Conclusion: Both of our cases are consistent with what has already been reported in the literature confirming the development of PostCOVID arthritis and strengthen the impending necessity of wider studies to identify rheumatologic manifestations in the short‐ and long‐terms after surviving COVID‐19.