bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preventive intraperitoneal chemotherapy in treating gastric cancer with high-risk peritoneal carcinomatosis
Authors: Захаренко Александр , Беляев Михаил , Вервекин Илья , Палтышев Илья 
Published: April 2023

Прогрессирование рака желудка после радикального лечения является крайне неблагоприятным фактором, определяющим дальнейший прогноз жизни пациента. При этом канцероматоз брюшины - наиболее частый вариант прогрессирования, при котором возможности системной химиотерапия весьма ограничены. Современные же методы внутрибрюшинной химиотерапии при раке желудка и перитонеальном канцероматозе применяются, однако их эффективность достаточно ограничена. Профилактика развития канцероматоза могло бы уменьшить частоту прогрессирования, тем самым улучшить прогнозы после радикального лечения при неметастатическом местно-распространенном раке желудка. Роль профилактической внутрибрюшинной химиотерапии в лечении неметастатического рака желудка является областью продолжающихся исследований. Представленный обзор литературы освещает исследования, касаемые имеющихся регионарных методов внутрибрюшинной химиотерапии, применяющихся с целью профилактики перитонеального канцероматоза в процессе комбинированного радикального лечения рака желудка с высоким риском канцероматоза брюшины. Проведен поиск литературы по базам данных Scopus, Web of Science, PubMed, РИНЦ. При анализе использованы источники, индексируемые в базах данных Scopus и Web of Science (99%), РИНЦ (1%), а также базы данных клинических исследований Национальной медицинской библиотеки (NLM) ClinicalTrials.gov и реестра клинических испытаний США ICH GCP.
Более 50 % работ опубликованы за последние 5 лет. Для написания данного литературного обзора было использовано 48 источников.
The role of etiopathogenesis in shaping local immune responses in squamous cell oropharyngeal cancer
Authors: Стукань Анастасия , Чухрай Ольга , Максименко Софья 
Published: April 2023

Актуальность. Установлено, что несмотря на инфильтрацию опухоли иммунокомпетентными клетками, зачастую плоскоклеточный рак головы шеи (ПРГШ) демонстрирует именно иммуносупрессивный тип микроокружения, что влияет на результаты лечения и диктует поиск новых прогностических маркеров и мишеней терапии.
Цель исследования. Изучить состав иммунных клеток при орофарингеальном плоскоклеточном раке (ОФПКР) и тип экспрессии PD-L1 (CPS, TPS) в зависимости от ВПЧ-статуса, пола и возраста.
Материалы и методы. В исследование кафедры онкологии КубГМУ на базе ГБУЗ КОД №1, г. Краснодара, с 2020 г. до июня 2022 г. включено 65 р16-негативных (52 %) и 60 р16-позитивных (48 %) больных ОФПКР. У 86 пациентов выполнена оценка уровня TILs, при иммуногистохимическом анализе изучены компоненты иммунного микроокружения по маркерам CD4, CD8, CD68, CD163, CD20, экспрессия PD-L1. Статистический анализ выполнен с использованием статистического пакета IBM SPSS Statistics v. 22.
Результаты. ВПЧ-позитивный статус ассоциирован с раком нёбных миндалин (р = 0,021), более высоким уровнем опухоль-инфильтрирующих лимфоцитов (TILs) (p = 0,007), вероятно, за счёт Тregs ввиду более достоверной связи с CD4+ TILs (р = 0,007), чем с CD8+ TILs (р = 0,033). ОФПКР у женщин в сравнении с мужчинами чаще представлен раком миндалин (р ˂ 0,001), характеризуется высокими значениями CD4+ TILs (р = 0,021) и CD8+ TILs (р = 0,035), однако более высоким иммунорегуляторным индексом (ИРИ) CD4/CD8 (р = 0,021). У женщин установлен более высокий уровень экспрессии PD-L1 на опухолевых клетках (TPS) (р = 0,009) и комбинированный показатель (CPS) (р = 0,018), чем у мужчин. Более высокие значения CPS и TPS выявлены при CD4+TILs ˂ 30 % (р = 0,001, р = 0,005 соответственно) и при CD68 ˂ 8,5 % (р = 0,001). N+ связано с высоким уровнем CPS PD-L1. У ВПЧ-позитивных больных выявлен более высокий уровень экспрессии маркера CD20+В-лимфоцитов (р = 0,02) в группе моложе 55 лет и уровень CD4+TILs ≥ 30 ассоциирован с более высокими значениями CD20 (р = 0,002).
Заключение. Тип формирования микроокружения ОФПКР и степень иммунной супрессии различается в зависимости от пола, возраста, ассоциации с транскрипционно активной ВПЧ-инфекцией.
The Role of Compliance System in Monitoring and Controlling Public Administration
Authors: Luengo Claudia Abe Gargel , Vieira Saulo Fabiano Amâncio , Nunes Augusto Luengo Pereira , Suguihiro Vera Lucia Tieko 
Published: May 2023

Objective: The objective of this study is to survey the state of the art of Public Administration Compliance in the national scientific domain, analyzing its scope, evolution, and authorship network.
Problem: While there are several studies and surveys on Compliance, they are primarily aimed at the private administration, with limited attention given to its application in the public sector. As such, this study aims to address the gap in knowledge regarding Compliance in Public Administration and contribute to the understanding of its current state of the art in the national context.
Method: This study employs a quantitative and descriptive approach, utilizing bibliographic research to collect data. The content analysis technique was applied to selected scientific journals from the SPELL electronic library to analyze the state of the art of Compliance in Brazilian Public Administration. The study also utilizes bibliometric laws to verify the authorship network and identify trends in publication over the years.
Results: The study identified the Revista de Administração Pública as the journal that most reported on the subject, with a significant growth in publications over the years, particularly in 2019 and 2020. The analyzed articles fitted Lotka's law, but there was no applicability of Bradfort's and Zipf's law. The authorship network had a density of 0.037, which is considered weak. The study also identified the most cited articles on Compliance in the national domain, serving as an introductory guide for researchers in this area.
Conclusions: This study contributes to the mapping and identification of the state of the art of Compliance in Brazilian Public Administration, highlighting its evolution over the years, the contributions, and the authorship network. The findings serve as a useful guide for researchers in this area and provide insights into the current state of knowledge on the subject in the national context.
Enhancing Corporate Responsibility: The Importance of Human Rights Compliance Systems and the Shortcomings of Brazilian Decree N. 9.571/2018
Authors: Adamatti Bianka , Ferreira Eduardo Adolfo 
Published: May 2023

Objective: To analyze Decree No. 9.571/2018 and highlight the importance of implementing Human Rights Compliance systems in national and multinational companies, emphasizing their positive influence on business results and reputation.
Problem: While some companies have adopted Human Rights policies, the absence of a mandatory requirement to implement Human Rights Compliance systems in national and multinational companies results in a guideline without practical effectiveness. This study aims to identify the need for mandatory implementation of Human Rights Compliance programs in companies to promote the protection and encouragement of Human Rights in the corporate-business environment.
Method: This study employs a qualitative approach, utilizing document analysis to examine Decree No. 9.571/2018 and its implications. The study also draws upon literature related to Human Rights Compliance programs, Corporate Social Responsibility, and their impact on business results and reputation.
Results: The study demonstrates the importance of implementing Human Rights Compliance systems in national and multinational companies, highlighting their potential positive impact on business results and reputation. The absence of a mandatory requirement for implementation limits the effectiveness of the decree and the promotion of Human Rights in the corporate-business environment.
Conclusions: This study emphasizes the need for mandatory implementation of Human Rights Compliance systems in national and multinational companies. Such implementation will promote the protection and encouragement of Human Rights in the corporate-business environment while positively influencing business results and reputation. The study concludes that Decree No. 9.571/2018, while an important step, is insufficient in promoting effective Human Rights Compliance programs in companies and should be revised to include mandatory implementation requirements.
The temporal development of memory processes in source monitoring: An investigation with mouse tracking
Authors: Tanyas Hilal , Kuhlmann Beatrice G. 
Published: May 2023

AbstractThe present study investigated whether we first remember an item (e.g., a word itself) and then its source (e.g., position on the screen) or whether the retrieval of item and source information can (partially) overlap. Participants were tested on the source either in immediate sequence to item recognition (as standard in source-monitoring research) or following as a separate block after full completion of the item recognition test to separate these processes in time, providing a baseline. Using the mouse-tracking procedure during the item and source tests, we analyzed how item and source decisions unfolded qualitatively over time. Despite no significant difference in the aggregated trajectory curvatures, more thorough analyses based on the individual trajectories revealed differences across the test formats. In the standard format, trajectories were less curved in the source than in the item test. In contrast, in the blocked format, this difference was in the other direction with source showing more curved trajectories than item. Alternative interpretations of mouse-trajectory curvatures on the source-monitoring paradigm and what their difference may imply for item and source processing are discussed.
Entre persecuciones y crímenes, los códigos de ética
Authors: Vargas Pedro 
Published: April 2023

Jurar y aceptar códigos de conducta, que no son otra cosa que códigos de ética, constituyen la entrada a la profesionalidad médica como a la dedicación a la investigación. “Los profesionales de la Medicina tienen deberes, obligaciones, privilegios y un status protegido, pero también se rigen por los más altos estándares éticos”, nos dice Phalen. El Colegio Médico de Panamá lo recuerda en su Código de Ética, cuando trae la frase de Rabelais, médico y filósofo del siglo XVI: “la ciencia sin conciencia es la ruina del alma”, para resaltar lo “indispensable de una permanente reflexión ética que fortalezca la conciencia y nos recuerde el núcleo de vocación y servicio al prójimo”.

Los humanos más tempranos ya practicaron especializaciones profesionales relacionadas con la salud, como lo revelan hallazgos arqueológicos y estudios antropológicos. Los primeros médicos en la historia, ambos nacidos en Egipto, Imhotep, varón y Merit Ptah, mujer, declararon juramentos a sus dioses, nos sigue relatando Robert F. Phalen, basados en varios atributos éticos: no mentir, no matar, no engañar.
PENGEMBANGAN MEDIA PEMBELAJARAN MATEMATIKA BERBANTUAN GEOGEBRA UNTUK MENINGKATKAN KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS SISWA
Authors: Rangkuti Rizki Kurniawan , Suprihatiningsih Siti , Rahayu Sri , Razy Miftah Ar 
Published: April 2023

Penelitian ini membahas tentang pengembangan media pembelajaran matematika berbantuan GeoGebra untuk meningkatkan kemampuan pemahaman konsep matematis siswa. (1) Untuk mengetahui bagaimana proses pengembangan media pembelajaran matematika berbantuan GeoGebra untuk meningkatkan kemampuan pemahaman konsep matematis siswa, (2) Untuk mengetahui bagaimana tingkat (kevalidan, kepraktisan, dan keefektifan) media pembelajaran matematika berbantuan GeoGebra untuk meningkatkan kemampuan pemahaman konsep matematis siswa. Jenis penelitian yang digunakan adalah Research and Development (Penelitian dan Pengembangan) dengan mengacu pada model pengembangan ADDIE, yaitu Analysis (Analisis), Design (Perancangan), Development (Pengembangan), Implementation (Penerapan), dan Evaluation (Evaluasi). Berdasarkan hasil uji coba media pembelajaran matematika berbantuan GeoGebra, diperoleh lembar kerja siswa berbantuan GeoGebra, angket respon siswa, rencana pelaksanaan pembelajaran dan tes pemahaman konsep pada interval 2,5 ≤ 𝑀 < 3,5 dengan kategori valid. Media pembelajaran matematika yang telah valid kemudian di terapkan dalam proses pembelajaran untuk melihat kepraktisan dan keefektifan media pembelajaran. Media pembelajaran yang dikembangkan dinyatakan praktis dengan melihat hasil analisis angket respon siswa berada pada persentase 80%. Keefektifan media pembelajaran dilihat dari hasil analisis tes hasil belajar yang menunjukkan bahwa persentase ketuntasan belajar siswa sebesar 80% dan persentase ketidaktuntasan sebesar 20% selain itu, persentase aktivitas siswa sebesar 62,14%. Maka media pembelajaran berbantuan GeoGebra yang dikembangkan valid, praktis, dan efektif.
L’impensé de la République
Authors: Lazorthes Frédéric 
Published: May 2023

Les terribles attentats qui ont marqué l’année 2015 en France ont rendu plus nécessaire que jamais le sentiment d’appartenir à un gouvernement commun par-delà les divisions. Le recours aux valeurs républicaines sera-t-il une réponse suffisante face à la décomposition civique ? Ne vaudrait-il pas mieux retrouver le sens d’une république libérale qui invite les citoyens à prendre part à un gouvernement libre plutôt que de réclamer toujours plus d’autorité ?
L’aviation française en 1940. 1. Le « mystère » du nombre des avions
Authors: Nassiet Michel 
Published: May 2023

Sur le nombre des avions français en 1940, d’apparentes incertitudes ont fait alléguer que beaucoup n’auraient pas été engagés dans la bataille, ce qui a été interprété comme une impéritie. On précise ici comment ce prétendu « mystère » résulte de biais dans des comptages grossiers. Le réarmement aérien n’ayant été décidé qu’en mars 1938, l’étude de deux statistiques, au 1 er février et au 10 mai 1940, permet de mesurer les avancées inégales du processus de rénovation de la flotte aérienne. Dans le cas de la chasse, une seconde rénovation dut être menée au cours même de la bataille, ce qui fut chaotique. La finalisation des appareils se heurtait à de multiples et inévitables difficultés techniques et industrielles. Pire encore, cependant, était un autre handicap, l’insuffisance des ressources humaines : le manque de mécaniciens et de pilotes.
Knee pain – thinking beyond degeneration: a systematic review
Authors: Kaur J. , Gera C. , Malik M. , Pawalia A. 
Published: May 2023

Abstract
Knee pain is the most common and challenging pain, that affects the performance and activities of daily living. Apart from the bones, the surrounding neuromuscular structures too are an integral part of the knee joint. The development of knee pain due to these surrounding neuromuscular structures, i.e. hip joint and ankle-foot complex is studied in this literature review. This systematic review was done for the purpose to summarise the literature mainly related to various neuromuscular factors related to neuro-muscle imbalances that affect knee pain other than degeneration. Observational studies related to knee pain published up to 2020 were reviewed in this paper. Strength of hip muscles and foot alignment were included in the study. We searched electronic database online for articles on ‘muscular imbalance that causes knee pain’ from Google scholar & PubMed the quality of the selected researches was measured by using PEDro scale. Of the total, 14 selected studies demonstrated that individuals with knee pain had decreased muscular strength for hip abduction, external rotation and extension on the affected side compared with healthy individuals. Flat foot, abnormal Q angle and over pronation or supination of foot can also results in knee pain. This review concluded that hip muscle weakness and abnormal subtalar mal-alignment place extra stress on knee and create muscular imbalance leading to knee pain. This should be prevented by either proper posture or strengthening programs.
Single Cell Analysis of High-Parameter Histology Images Using Histoflow Cytometry
Authors: Jain Rajiv W , Elliott David A , Yong V Wee 
Published: May 2023

Abstract
Immunofluorescence histology is commonly used to study immune cells in tissues where the number of fluorescence parameters is normally limited to four or less. This makes it impossible to interrogate multiple subsets of immune cells in tissue with the same precision as flow cytometry. The latter, however, dissociates tissues and loses spatial information. To bridge the gap between these technologies, we developed a workflow to expand the number of fluorescence parameters that can be imaged on widely available microscopes. We instituted a method for identifying single cells in tissue and exporting the data for flow cytometry–based analysis. This histoflow cytometry technique successfully separates spectrally overlapping dyes and identifies similar numbers of cells in tissue sections as manual cell counts. Populations identified through flow cytometry–like gating strategies are mapped to the original tissue to spatially localize gated subsets. We applied histoflow cytometry to immune cells in the spinal cords of mice with experimental autoimmune encephalomyelitis. We ascertained that B cells, T cells, neutrophils, and phagocytes differed in their frequencies in CNS immune cell infiltrates and were increased relative to healthy controls. Spatial analysis determined that B cells and T cells/phagocytes preferentially localized to CNS barriers and parenchyma, respectively. By spatially mapping these immune cells, we inferred their preferred interacting partners within immune cell clusters. Overall, we demonstrate the ease and utility of histoflow cytometry, which expands the number of fluorescent channels used in conventional immunofluorescence and enables quantitative cytometry and spatial localization of histological analyses.
Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma
Authors: Suen Andrew O , Chen Fengqian , Wang Sheng , Li Ziyi , Zhu Jing , Yang Yang , Conn Olivia , Lopez Kerri , Cui Ping , Wechsler Laurence , Cross Alan , Fiskum Gary , Kozar Rosemary , Hu Peter , Miller Catriona , Zou Lin , Williams Brittney , Chao Wei 
Published: May 2023

Abstract
Severe traumatic injury leads to marked systemic inflammation and multiorgan injury. Endogenous drivers such as extracellular nucleic acid may play a role in mediating innate immune response and the downstream pathogenesis. Here, we explored the role of plasma extracellular RNA (exRNA) and its sensing mechanism in inflammation and organ injury in a murine model of polytrauma. We found that severe polytrauma—bone fracture, muscle crush injury, and bowel ischemia—induced a marked increase in plasma exRNA, systemic inflammation, and multiorgan injury in mice. Plasma RNA profiling with RNA sequencing in mice and humans revealed a dominant presence of miRNAs and marked differential expression of numerous miRNAs after severe trauma. Plasma exRNA isolated from trauma mice induced a dose-dependent cytokine production in macrophages, which was almost abolished in TLR7-deficient cells but unchanged in TLR3-deficient cells. Moreover, RNase or specific miRNA inhibitors against the selected proinflammatory miRNAs (i.e., miR-7a-5p, miR-142, let-7j, miR-802, and miR-146a-5p) abolished or attenuated trauma plasma exRNA-induced cytokine production, respectively. Bioinformatic analyses of a group of miRNAs based on cytokine readouts revealed that high uridine abundance (&gt;40%) is a reliable predictor in miRNA mimic-induced cytokine and complement production. Finally, compared with the wild-type, TLR7-knockout mice had attenuated plasma cytokine storm and reduced lung and hepatic injury after polytrauma. These data suggest that endogenous plasma exRNA of severely injured mice and ex-miRNAs with high uridine abundance prove to be highly proinflammatory. TLR7 sensing of plasma exRNA and ex-miRNAs activates innate immune responses and plays a role in inflammation and organ injury after trauma.
The mysterious Hebrew word שׂרקים in Zechariah 1:8
Authors: Chia Philip S. 
Published: May 2023

The Hebrew word שׂרקים in Zechariah 1:8 is a mysterious word. The disappearance of the Hebrew word שׂרקים in Zechariah 1:8 from the rest of the Book of Zechariah and the unknown meaning of שׂרקים itself are the reasons for this mystery. Zechariah 1:8 does not only abandon two colours: the black horses and the spotted (dappled) horses but also this verse adds שׂרקים or the sorrel ones, which are not recorded in Zechariah 6:2–3 and 6:6–7. The appearance of שׂרקים in Zechariah 1:8, therefore, creates disagreement colours with Zechariah 6:2–3 and 6:6–7. In addition, Gelston states that the Hebrew word שׂרקים is probably unknown to the ancient translators. This unknown meaning causes different translations of שׂרקים in ancient texts. This article, thus, attempts to unveil this mystery with textual criticism as its methodology.Intradisciplinary and/or interdisciplinary implications: This research emphasises on the importance of textual criticism to unveil the unknown meaning of קים in Zechariah 1:8.
Listening between the Lines
Authors: Banerjee Priyanka , Verma Niket , Mohan Charu , Rustagi Shaifaly M. , Nair Bindu T. , Rautela Archna 
Published: May 2023

Background and Aim:
Establishing good communication with patients is an essential component of good doctor–patient relationships and has a positive impact on health outcomes. A vital component of communication is nonverbal communication (NVC). NVC may reinforce or contradict our verbal comments, thereby altering the meaning of a message and its outcomes. Hence, it is imperative that medical students are made aware of NVC. The present study was undertaken to develop and implement a module for NVC skills and assess the perception of students and faculty.

Materials and Methods:
The study was conducted with students of 2nd professional MBBS. Participation was voluntary and approval was taken from the institutional ethical committee. All the contents of the module were jointly developed by the core faculty members. The module was conducted across three sessions and included role plays, exposure to simulated patients, an interactive lecture, and a focused small-group discussion. Feedback was obtained from students and faculty facilitators after conclusion of the third session.

Results:
Fifty-two students and seven faculty facilitators participated in the study. Fifty students (96%) agreed that the module was helpful in improving their NVC skills. All 52 students (100%) agreed that they felt more confident interacting with patients after attending the sessions. Forty-four students (84.6%) strongly agreed that they would attend such sessions in future also. The suitability of the module as a whole for inclusion in the curriculum was endorsed by all participants (100%). The faculty members felt that the most encouraging aspects of the module were its implementation in a nonthreatening environment, maintaining privacy during interactions with simulated patients, and self-assessment of the interaction.

Conclusion:
With regard to the feasibility and acceptability of the module, 100% of the participants and faculty facilitators agreed that the module should be included in the undergraduate curriculum.