bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Outcomes of Pediatric, Adolescent, and Young Adult Oncology Patients With Non-neutropenic Fever: A Scoping Review of the Literature
Authors: Wagner Annabelle , Akarsu Yeliz , Remke Marc , Schoendorf Dominik , Huebner Johannes , Lehrnbecher Thomas , Hufnagel Markus , Bochennek Konrad , Simon Arne 
Published: January 2025

Background:
There are established and well-followed guidelines for pediatric oncology
patients who have neutropenic fever. However, there are no explicit criteria for this patient
group, and over 50% of pediatric oncology patients with fever do not present with neutropenia.

Objective:
In this scoping review, we have explored the outcomes of non-neutropenic fever in pediatric,
adolescent, and young adult patients with cancer-directed treatment. The results of this
scoping review should assist in the creation of a guideline for the management of non-neutropenic
fever in this group of patients.

Method:
Multiple electronic databases and reference lists were searched (PubMed, MEDLINE
CENTRAL, and Google (first 100 results only)). Included are retrospective and prospective cohort
studies on the management and outcome of pediatric oncology patients with non-neutropenic
fever that have been published after the year 2000.

Results:
Seventeen studies with a total of 10.845 fever episodes were included, that address the
treatment and outcome of patients with non-neutropenic fever. The rate of bacteremia was 1.6 -
14.4% (mean 5.8%). The mortality rate was low due to non-bacterial causes. Across different
studies, proposed risk factors for bacteremia were higher temperature, prolonged fever over 72
hours, ill-appearing patients, chills, hypotension, leukocytosis, infancy, and the presence of a Broivac/
Hickman catheter. Limitations to this study are the risk of bias, and potential incomplete identification
of relevant studies pertinent to the research questions asked.

Conclusion:
Due to significant heterogeneity, the published data so far are not sufficient to propose
evidence-based guidelines for pediatric oncology patients with non-neutropenic fever.
Prospective, multicenter registries based on uniform definitions are needed. No funding was received
for this manuscript.
Next-Generation Biomaterials and Tissue Engineering: Innovations, Challenges, and Future Directions
Authors: Aljabali Alaa A. A. , Alwattar Jana K. , Obeid Mohammad A. , Tambuwala Murtaza M. 
Published: January 2025

Abstract:
Biomaterials and tissue engineering have undergone significant advances, particularly
with the integration of nanoscience technology. Recent progress in nanostructured scaffolds
and nanoparticle-based delivery systems has provided novel opportunities for tissue regeneration.
However, the key challenges remain and must be addressed. These include the optimization
of the long-term stability of nanoengineered constructs and addressing the concerns
regarding nanotoxicity. Fine-tuned mechanical properties enable the adoption of vehicle-based
targeted approaches to drug and gene delivery. However, much remains to be learned regarding
the interactions between nanomaterials and tissues. Comprehensive safety assessments and
standardized toxicity evaluations are essential for clinical translation. These emerging technologies
combine the three-dimensional bioprinting of induced pluripotent stem cells with nanomaterials
and new pathways for personalized medicine. Nanoengineered smart materials and
biosensors have the potential to enable real-time monitoring of engineered tissues, which can
pave the way for unparalleled advances in personalized therapies, particularly for chronic diseases.
The bioactivity of nanomaterials offers new avenues for tissue regeneration. This review
explores the status, successes, challenges, and future directions of biomaterials and tissue engineering,
with a specific focus on nanoscience applications. Key areas for future research include
nano-bio-interfaces, in situ tissue remodeling, and biofabrication techniques. These insights
can guide researchers to navigate the rapidly evolving landscape of nanoscience, related
biomaterials, and tissue engineering. The integration of nanomaterials into tissue engineering
is an emerging and advanced field that has significant implications for regenerative medicine.
A Three-agent Regimen for Triple Negative Breast Cancer Treatment
Authors: Wang Shaojun , Huang Congxiu , Zhu Ying , Wang Min , Wang Wei , Liu Caixia , Su Wuyun 
Published: January 2025

Background:
Triple-negative breast cancer (TNBC) has a poor prognosis with current
treatment options. Novel therapeutic strategies are urgently needed to enhance treatment outcomes
for TNBC.

Objective:
This study evaluated the efficacy of a three-agent regimen compared to existing treatment
regimens in a TNBC mouse model, and elucidated its potential mechanisms of action.

Methods:
The TNBC xenograft tumor mouse model was established using a 4T1 cell line in female
BALB/c mice. Mice were treated with the three-agent regimen and other comparative treatments.
Tumor volume was monitored to assess the anti-tumor effects. Biochemical and pathological
evaluations were conducted to examine the impact of the regimen on anti-tumor immunity, anti-
tumor angiogenesis, and tumor cell apoptosis.

Results:
The three-agent regimen consisting of SIN+BEV+PAB demonstrated significant anti-tumor
efficacy compared to controls, PAB alone, SIN+PAB, and BEV+PAB groups from day 9 of
drug administration. The superior anti-tumor effect of SIN+BEV+PAB was primarily attributed to
enhanced anti-tumor immunity, evidenced by increased percentages of CD4+ and CD8+ T cells,
elevated IFN-γ levels, and decreased percentages of Tregs, reduced levels of TGF-β, IL-6, and
IL-10. Additionally, the regimen showed potent anti-angiogenic effects by reducing VEGF expression
and micro vessel density (MVD). Furthermore, it promoted tumor cell apoptosis through upregulation
of BAX and cleaved caspase3, while downregulating Bcl2.

Conclusion:
These findings suggest that the novel three-agent combination of SIN+BEV+PAB
may prove beneficial in improving treatment outcomes for patients with TNBC. The development
of this regimen, which may be eligible for patent protection, could facilitate its introduction as a
new therapeutic option for advanced TNBC in clinical practice.
Why is it Important to Assess and Treat Alexithymia in the Cardiologic Field? An Overview of the Literature
Authors: Sancassiani Federica , Montisci Roberta , Meloni Luigi , Nardi Antonio Egidio , Carta Mauro Giovanni 
Published: January 2025

Background:
Alexithymia has been found to be associated with several somatic illnesses, such as cardiovascular, indicating that it might be a risk factor for early death in the long-term course of post-myocardial infarction. From the cardiology perspective, the aim was to collect current evidence about the relationship between alexithymia and somatic illness.

Methods:
The literature was synthesized and summarized in a narrative format. The literature search was carried out in PubMed. Pertinent studies published in the last 50 years written in English were included and organized by three main topics (“The relation between alexithymia and somatic illness from the cardiology perspective”; “How do assess alexithymia?”; “Treating alexithymia”) to be discussed.

Results:
High alexithymia is a dimensional trait that affects around 10% of the general population and up to 55% of people with essential hypertension. Also, the link between alexithymia and cardiovascular activity has been pointed out. There are several validated tools to assess alexithymia, as well as treatment options.

Conclusion:
Knowledge about the main features of alexithymia, as well as its assessment and treatment, can promote a multifactorial approach to the primary, secondary, and tertiary prevention of cardiac diseases.
A Systematic Evaluation of Telehealth using Recent COVID-19 Data
Authors: Dar Mubashir Hassan , Sofi Hilal Ahmad , Garg Amar Prakash , Akthar Salman , Singh Punit Kumar 
Published: January 2025

Background:
The coronavirus disease-19 (COVID-19) epidemic is a global public health issue. The COVID-19 outbreak can be managed with the help of telehealth. This systematic review sought to determine the role that telehealth services played in the COVID-19 epidemic in terms of disease management, diagnosis, treatment, and prevention.

Methods:
Five databases were searched for this systematic review: PubMed, Scopus, Embase, Web of Science, and ScienceDirect. As of December 31st, 2019, all published papers were written in English and appeared in peer-reviewed journals. These studies precisely described any use of telehealth services in all facets of healthcare during the COVID-19 outbreak. The quality of included studies was reviewed by two independent reviewers, who also gathered information and examined the search results. The Critical Appraisal Skills Program (CASP) criteria were used to evaluate quality. The results were compiled into a narrative synthesis and reported.

Results:
Of the 142 search results, eight studies were pertinent for inclusion. Currently, telemedicine is, without a doubt, suitable for reducing the risk of COVID-19 transmission among separated medical staff and patients. This approach might be used to reduce any direct physical contact, offer ongoing care to the neighbourhood and ultimately reduce the COVID-19 epidemic's morbidity and mortality rates.

Conclusion:
Telehealth enhances the delivery of healthcare services. In order to provide care during the COVID-19 outbreak while ensuring the safety of both patients and medical personnel, telemedicine should be a crucial tool.
Special properties of transonic flows in a channel with a lenticular bump
Authors: Paciorri Renato , Assonitis Alessia , Bonfiglioli Aldo 
Published: January 2025

Abstract
The present study focuses on particular properties of transonic flows through a planar channel featuring a circular bump on the lower wall. The selected geometry is reminiscent of the region surrounding the trailing edge of an airfoil at zero angle of attack and the resulting flow pattern is indeed similar to the fishtail shock-pattern that characterizes airfoils flying at nearly sonic speed. Numerical simulations have been conducted by solving the inviscid Euler equations using both a commercial and an in-house CFD code; discontinuities are modeled using shock-capturing in the former and shock-fitting in the latter. Numerical experiments reveal different shock-patterns obtained by independently varying the inlet Mach number and the outlet-to-inlet static pressure ratio. When shock-interactions occur, shock-polar analysis reveals that the branching point can be modeled using either von Neumann’s three-shock-theory or Guderley’s four-wave-theory, depending on the inlet Mach number. Furthermore, for certain pairs of boundary conditions, multiple solutions have been observed.
Food Eco-Covering: Characterization of Biodegradable Films Made With Starch From Andean Oxalis tuberosa
Authors: Peralta-Guevara Diego E. , Choque-Quispe David , Ligarda-Samanez Carlos A. , Ramos-Pacheco Betsy S. , Taipe-Pardo Fredy , Diaz-Barrera Yasmine , Agreda-Cerna Henrry W. 
Published: January 2025

Objective: This research focused on the characterization of biodegradable films made from nopal (Opuntia ficus-indica) mucilage and oca (Oxalis tuberosa) starch to cover food.

Theoretical Framework: This study is grounded in the growing environmental concerns surrounding conventional plastics and the urgent need for sustainable alternatives in the food industry. The research builds upon the emerging concept of circular economy, focusing on biodegradable materials derived from underutilized agricultural resources.

Method: Nine biodegradable films were prepared by thermoforming and dried at 40, 50, and 60 °C. Their physical properties and degradation versus temperature were evaluated by thermogravimetry, and structural identification was carried out by infrared (IR) spectroscopy.

Results and Discussion: The films exhibited a water solubility more significant than 91%. Water activity ranged between 0.402 and 0.573, correlating with the percentage of humidity (<25.3%). The starch and pectin content influenced these properties, as well as transparency (T<2.08). Thermogravimetric analysis revealed that the films reached the highest mass loss at around 300 °C. Finally, the IR analysis demonstrated the relationship between the components and the new molecular arrangement of the films, influenced by the concentrations of oca starch.

Research Implications: It provides significant implications for sustainable food packaging and agricultural waste utilization, offering a potential solution to reduce plastic waste in the food industry. The findings suggest that local agricultural products can be transformed into value-added materials with environmental benefits.

Originality/Value: The study offers unique value through its comprehensive characterization and its potential for promoting local agricultural resources in sustainable packaging solutions.
Industrial Engineering and Sustainable Development
Authors: Pimenta Clayson Cosme Da Costa , Prieto Daniel Zarzuelo , Primo Luís Rodríguez , Riet Ester Rodriguez Van 
Published: January 2025

Objective: The objective of this study is to establish the relationship between industrial engineering and sustainable development.

Theoretical Framework: Sustainable industrial development ensures that resources are used sparingly and efficiently. To achieve resource productivity, companies must optimize the supply chain by analyzing and examining the factors and variables of each company.

Method: The methodology is based on the critical review of scientific literature and the integration of findings through qualitative meta-analysis, with the objective of identifying patterns, trends and key areas of intervention at the intersection of these two disciplines.

Results and Discussion: The results obtained revealed that industrial sustainability is no longer an option; it is a corporate obligation, the Spanish business fabric wants to be at the forefront and companies have begun to assume their role as key players in achieving the 2030 Agenda, implementing strategies based on achieving a sustainable, decarbonized, competitive and resource-efficient economy.

Research Implications: It discusses how the results can be applied or influence practices in the field of achieving sustainable development goals, minimizing their environmental footprint, maintaining economic growth, social advancement and the quality of life of the people who compose it.

Originality/Value: This study contributes to the literature by establishing the relationship between industrial engineering and sustainable development.
Sanitation Challenges in the Complexo da Maré
Authors: Silveira Mayara Rodrigues da , Santos Guilherme Bompet , Faria Giovana Figueiredo , Mendes Stephanie Nayane Tomaz , Machado Anna Virginia Muniz 
Published: January 2025

Objective: The objective of this study is to investigate the challenges faced by vulnerable urban communities, such as Complexo da Maré, addressing the impacts on public health, the environment, and constitutional rights, with the aim of exposing the vulnerability of these communities and highlighting the difficulties related to the universalization of basic sanitation, aligned with constitutional rights and the Sustainable Development Goals.

Theoretical Framework: This section presents the key concepts and theories that underpin the research. Key aspects include the lack of basic sanitation as a reflection of the country’s structural inequalities, the 1988 Constitution, which considers sanitation a social right, and the regulatory framework (Laws No. 11.445/2007 and No. 14.026/2020), which reinforces the importance of universal access.

Method: The methodology adopted for this research includes a descriptive, qualitative, and documentary approach, based on a literature review. Articles, theses, and reports from the sanitation sector, with a 20-year time frame, were consulted. Data collection was conducted through the analysis of these documents to understand the context and challenges related to sanitation in vulnerable urban communities.

Results and Discussion: The results revealed the precarious sanitation conditions in Complexo da Maré, with open sewage and significant impacts on public health. Environmental racism and social exclusion exacerbate the situation, while community initiatives, though promising, do not address the existing gaps. In the discussion section, these results are contextualized in light of the theoretical framework, highlighting the identified implications and relationships. Possible discrepancies and limitations of the study are also considered.

Implications of the Research: The practical and theoretical implications of this research are discussed, highlighting the need for effective public policies that use sanitation as a tool for social inclusion and environmental justice. Collaboration between government and communities is essential for concrete progress. These implications may impact public policy, public health, the environment, and sustainable urban development.

Originality/Value: This study contributes to the literature by providing a detailed analysis of sanitation in Complexo da Maré, connecting it to constitutional rights and the Sustainable Development Goals (SDGs). The relevance and value of this research are evident in its exploration of practical community solutions, contributing to the debate on socio-environmental justice and proposing the universalization of basic sanitation as a way to reduce inequalities and ensure sustainability in marginalized communities.
Impact of an Independent Patient Centered Medical Home Clinic Experience during Residency Training on Post-Residency Confidence
Authors: Thompson Amy , Ashjian Emily , Kippes Kellie 
Published: January 2025

Description of the problem:
While previous studies have described the impact of incorporating a postgraduate year two (PGY2) Ambulatory Care resident on clinical outcomes and revenue, the impact of an independent Patient Centered Medical Home (PCMH) experience from the resident perspective has not been reported on. The purpose of this study was to determine the impact of an independent PCMH rotation on resident confidence.
Description of the innovation:
A longitudinal independent PCMH rotation has been part of our PGY2 Ambulatory Care residency since program inception. To determine the impact of this experience on resident confidence, a 23-item survey was developed and distributed electronically to all previous PGY2 Ambulatory Care residents who completed this experience.
Critical Analysis:
All invited residents (n=15) responded. Following PGY2 completion, 46.7% of respondents worked as a clinical pharmacist specialist at an academic medical center. The majority (86.7%) practiced in primary care and/or population health. Identified strengths of the experience included increased resident confidence in the following areas: independent practice model (100% indicated positive impact), having their own Collaborative Practice Agreement (86.7%), and building rapport with patients (80%) and providers (73.3%).
Implications:
An independent PCMH rotation during PGY2 Ambulatory Care training has a positive impact on post-residency clinical confidence.
Development and Assessment of an Online, Asynchronous State-Specific Pharmacy Law Continuing Education Program for Multistate Pharmacy Jurisprudence Examination Preparation
Authors: Peddi Apryl , Caldas Lauren , Sisson Evan , Yousufzai Sofia , Frankart Laura 
Published: January 2025

Description of the Problem: The Multistate Pharmacy Jurisprudence Examination (MPJE) is a licensure requirement for pharmacists. National pass rates for this exam are variable and have recently been decreasing nationally. Current support for graduates in pharmacy law courses and MPJE test preparation tools varies between states and institutions.
Description of the Innovation: The Virginia Commonwealth University School of Pharmacy created an online, asynchronous continuing education (CE) course that provides content specific to Virginia pharmacy laws and regulations. The course is divided into six modules, aligned with MJPE competency statements.
Critical Analysis: Of the 158 participants who have taken the CE, 26 responded to the survey (response rate = 16.5%) on pass rate success and resources used in preparation for MJPE. The majority (96%) of those who completed the CE passed their next attempt on the MJPE. Qualitative feedback was collected and evaluated using thematic analysis. This limited cross-sectional data requires this innovation to report only descriptive preliminary findings without generalizability.
Implications: The institution will continue to offer this CE. The CE creates a revenue stream for the institution and provides a resource for passing the Virginia MPJE.
Call to Action: Lead Pharmacy into the Next Decade
Authors: Fierke Kerry K , Lepp Gardner , McGugan Bridget , Brooks Marta 
Published: January 2025

Introduction
The pace of change in healthcare and throughout the world will only continue to escalate. This evolution of continuously changing information requires us to be responsive and innovative. There are more ways than ever to share information, and more need than ever to share best practices for leadership related to pharmacy. In keeping with the mission of INNOVATIONS in pharmacy (Iip), we invite you to share creative and dynamic scholarly leadership work.
MethodsThe traditional written manuscript is an author-centric form of scholarly output; the format, process, expediency, and familiarity of written manuscripts benefit authors, but may not be as easily consumed as more user-centric forms of information. The Iip leadership section team investigated alternative ways to disseminate the results of research work that don't include a traditional written manuscript.
Findings
We reached out to leaders across a variety of pharmacy work and practice settings to understand the importance of leadership today and the importance for leadership in pharmacy. Responses were common across pharmacy professionals in all settings; nearly every response mentioned that leadership is important to help motivate a team toward a shared goal or vision and to be a role model. Pharmacy leaders feel that leadership is needed to make decisions, take accountability and, especially in an area as highly regulated as healthcare, ensure regulations and procedures are followed and standards are upheld. At the same time, our current environment requires attention to new challenges such as a multigenerational workforce and artificial intelligence.
Call to Action
Through our work as scholars, we can provide evidence-based, pertinent, timely solutions to address these issues, in ways that make it easily transferable to broad audiences.
The future of pharmacy leadership is in our hands and awaits our unique insights. Traditional written manuscripts are valuable but may not fully connect with some people. The evolving landscape of healthcare leadership demands novel perspectives, creative applications, and open-minded evaluations.
Join us on this transformative journey. Submit your Innovative scholarly works to Iip.

This scholarship is connected to the following forms of scholarly works:
Call to Action: Lead Pharmacy into the Next Decade an Interactive Poster: https://doi.org/10.24926/iip.v15i4.6264
Call to Action: Lead Pharmacy into the Next Decade a Scholarly Narration: https://doi.org/10.24926/iip.v15i4.6265