bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graphene: Preparation, tailoring, and modification
Authors: Li Mingyao , Yin Bing , Gao Chunyan , Guo Jie , Zhao Cong , Jia Chuancheng , Guo Xuefeng 
Published: January 2023

AbstractGraphene is a 2D material with fruitful electrical properties, which can be efficiently prepared, tailored, and modified for a variety of applications, particularly in the field of optoelectronic devices thanks to its planar hexagonal lattice structure. To date, graphene has been prepared using a variety of bottom–up growth and top–down exfoliation techniques. To prepare high‐quality graphene with high yield, a variety of physical exfoliation methods, such as mechanical exfoliation, anode bonding exfoliation, and metal‐assisted exfoliation, have been developed. To adjust the properties of graphene, different tailoring processes have been emerged to precisely pattern graphene, such as gas etching and electron beam lithography. Due to the differences in reactivity and thermal stability of different regions, anisotropic tailoring of graphene can be achieved by using gases as the etchant. To meet practical requirements, further chemical functionalization at the edge and basal plane of graphene has been extensively utilized to modify its properties. The integration and application of graphene devices is facilitated by the combination of graphene preparation, tailoring, and modification. This review focuses on several important strategies for graphene preparation, tailoring, and modification that have recently been developed, providing a foundation for its potential applications.
An unconditionally stable third order scheme for mixed convection flow between parallel plates with oscillatory boundary conditions
Authors: Nawaz Yasir , Arif Muhammad Shoaib , Abodayeh Kamaleldin 
Published: January 2023

AbstractThis work proposes an unconditionally stable third‐order multistep technique for time‐dependent partial differential equations. Its unconditional stability is proved by employing von Neumann stability analysis, and constructed Matlab code is another solid proof of the existence of the such scheme. The scheme is constructed on three consecutive time levels, and a compact fourth‐order scheme is considered for spatial discretization. The convergence conditions are found when applied to the system of parabolic equations. The scheme is tested on two examples of flow between parallel plates. The mathematical model of heat and mass transfer of flow between parallel plates under the effects of viscous dissipation, thermal radiations, and chemical reaction is given and solved by the proposed scheme. The impact of some parameters, including radiation and reaction rate parameters, on velocity, temperature, and concentration profiles is also illustrated by graphs. The proposed scheme is also compared with the existing scheme, providing faster convergence than an existing one. The fundamental benefit of the proposed scheme is that it can give a compact fourth‐order solution to parabolic equations.
Challenges to corporate social responsibility adoption for sustainability: A picture fuzzy approach
Authors: Kasradze Mariam , Kamali Saraji Mahyar , Streimikiene Dalia 
Published: January 2023

Abstract
Corporate social responsibility (CSR) has become crucial to businesses seeking to adopt sustainable development. However, there are several challenges to CSR adoption for sustainability that the present research aims to identify and evaluate, in addition to assessing the EU's response to these challenges. To this end, a novel picture fuzzy SWARA-TOPSIS method is proposed to rank EU countries after identifying the challenges that they face through a literature review. The results indicate that out of eight identified challenges, “Leadership Mindset and Corporate Commitment” is the most significant issue to CSR adoption for sustainability. Additionally, Italy shows the best performance in adopting CSR for sustainability, while Malta shows the worst. These results are discussed, and policy implications are presented. Integr Environ Assess Manag 2023;19:1254–1275. © 2023 SETAC
An optimal diagnosis system for melanoma dermoscopy images based on enhanced design of horse herd optimizer
Authors: Ding Qi , Razmjooy Navid 
Published: January 2023

AbstractSkin cells grow in an orderly and controlled manner, in which old cells are pushed to the skin surface by healthy new cells, wherein they finally perish. However, when several cells damage DNA, new ones may start growing disorderly and can finally create cancer cells mass. Different types of skin cancer have been observed by experts. Although, melanoma, as one of the rarely happened cancers, is the most threatening type. Therefore, early detection of this type of cancer can be so useful for avoiding melanoma dangers and even helps to treat this type of cancer. The present paper proposes a new hierarchical procedure for the optimum diagnosis of melanoma cancer from dermoscopy images. Here, after image preprocessing, image segmentation is applied for the segmentation of the ROI. Then, the selection of features from the segmented images is performed and injected to a radial basis function‐based classifier to provide the final diagnosis of cancer. To deliver efficient results, the feature selection and the classifier have been optimized by a new design of Horse herd optimization algorithm (HHOA). The method is then implemented on the Society for Imaging Informatics in Medicine‐The International Skin Imaging Collaboration (SIIM‐ISIC) Melanoma dataset to validate its effectiveness and its achievements and also put in comparison with several different latest techniques. The results show that the proposed method with 95.46% precision provides the maximum performance among the others.
Requirements for human mesenchymal stem cell‐derived small extracellular vesicles
Authors: Li Qing , Li Bo , Ye Teng , Xu Wenrong , Yin Hang , Deng Zhifeng , Li Haiyan , Yan Xiaomei , Hao Xiaoke , Li Li , Tao Zhihua , Liu Bicheng , Chen Zhengsheng , Luo Lei , Qian Hui , Fu Qing‐Ling , Wang Qian , Zheng Lei , Wang Yang 
Published: January 2023

Abstract“Requirements for human mesenchymal stem cell‐derived small extracellular vesicles” is the first set of guidelines on human mesenchymal stem cell‐derived small extracellular vesicles (hMSC‐sEVs) in China, jointly drafted and agreed upon by experts from the Chinese Society for Extracellular Vesicles. It was released by the Chinese Research Hospital Association on 28 December 2021 and came into effect on 1 January 2022. This standard specifies the technical requirements, test methods and regulations, packaging, instructions for use, labeling, storage, transportation, and waste handling for hMSC‐sEVs, which apply to the production and quality control of hMSC‐sEVs. We hope that the publication of these guidelines will promote consensus on the research and application of human mesenchymal stem cell‐derived small extracellular vesicles and accelerate its international standardization.
Contributions of Clinical and Technical Factors to Longitudinal Change in Trabecular Bone Score and Bone Density: A Registry-Based Individual-Level Analysis
Authors: Leslie William D , Goel Heenam , Binkley Neil , McCloskey Eugene V , Hans Didier 
Published: January 2023

ABSTRACT
Lumbar spine trabecular bone score (TBS), a gray-level texture measure derived from spine dual-energy X-ray absorptiometry (DXA) images, is a bone mineral density (BMD)-independent risk factor for fracture. An unresolved question is whether TBS is sufficiently responsive to change over time or in response to widely used osteoporosis therapy at the individual level to serve as a useful biomarker. Using the Manitoba DXA Registry, we identified 11,643 individuals age 40 years and older with two fan-beam DXA scans performed on the same instrument within 5 years (mean interval 3.2 years), of whom 6985 (60.0%) received antiresorptive osteoporosis medication (majority oral bisphosphonate) between the scans. We examined factors that were associated with a change in lumbar spine TBS, lumbar spine BMD, and total hip BMD exceeding the 95% least significant change (LSC). Change exceeding the LSC was identified in 23.0% (9.3% increase, 13.8% decrease) of lumbar spine TBS, 38.2% (22.1% increase, 16.1% decrease) lumbar spine BMD, and 42.5% (17.6% increase, 24.9% decrease) total hip BMD measurement pairs. From regression models, the variables most strongly associated with significant change in TBS (decreasing order) were tissue thickness change, acquisition mode change, weight change, and spine percent fat change. Consistent with the insensitivity of TBS to oral antiresorptive therapies, use of these agents showed very little effect on TBS change. In contrast, for both spine BMD change and total hip BMD change, osteoporosis medication use was the most significant variable, whereas tissue thickness change, acquisition mode change, and weight change had relatively weak effects. In summary, change in spine TBS using the present algorithm appears to be strongly affected by technical factors. This suggests a limited role, if any, for using TBS change in untreated individuals or for monitoring response to antiresorptive treatment in routine clinical practice with the current version of the TBS algorithm. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
MiR‐526b targets lncRNA SLC16A1‐AS1 to suppress cell proliferation in triple‐negative breast cancer
Authors: Zhao Xingjuan , Fu Lei , Zhai Liqin , Yang Xuan , Gao Runfang 
Published: January 2023

AbstractThe present study investigated the potential interaction between miR‐526b and lncRNA SLC16A1‐AS1 in triple‐negative breast cancer (TNBC). Expression of miR‐526b and SLC16A1‐AS1 in TNBC tumor tissues and paired nontumor tissues from 60 TNBC patients was detected by real‐time polymerase chain reaction (RT‐qPCR). The interaction between miR‐526b and SLC16A1‐AS1 was evaluated with overexpression experiments, followed by RT‐qPCR. The proliferation and migration of cells were detected with cell counting kit‐8 assay and Transwell assay, respectively. Apoptosis of cells was assessed by cell apoptosis assay. The expression of apoptosis‐related proteins was quantified by Western blot analysis. MiR‐526b was predicted to bind with SLC16A1‐AS1. Overexpression of miR‐526b in TNBC cells decreased the expression levels of SLC16A1‐AS1, while overexpression of SLC16A1‐AS1 did not affect the expression of miR‐526b. In TNBC tissues, miR‐526b was downregulated in TNBC tissues, while SLC16A1‐AS1 was upregulated in TNBC tissues compared to that in nontumor tissues. The expression of SLC16A1‐AS1 and miR‐526b were inversely correlated. In vitro experiments showed that overexpression of SLC16A1‐AS1 promoted cell proliferation and invasion but suppressed cell apoptosis. MiR‐526b played an opposite role and suppressed the function of SLC16A1‐AS1. MiR‐526b is downregulated in TNBC and it targets SLC16A1‐AS1 to regulate proliferation, apoptosis, and invasion of TNBC cells.
Characteristics of CO2 adsorption and desorption on activated carbon in comparison with zeolite 13X and carbon molecular sieve and applications in biogas upgrading using vacuum pressure swing adsorption
Authors: Punpee Sirawich , Tongpadungrod Pensiri , Suttikul Thitiporn , Phalakornkule Chantaraporn 
Published: January 2023

AbstractBACKGROUNDBiogas upgrading is the process that increases the fraction of methane (CH4) in biogas, making the biogas suitable for use as vehicle fuel or as fuel with high and stable heating values for combustion engines. The advantages and disadvantages of activated carbon (AC) in CO2/CH4 adsorptive separation should be well understood before application for biogas upgrading. In the first part of this study, characteristics of CO2 adsorption and desorption on AC were investigated using Aspen Adsorption. In the second part, vacuum pressure swing adsorption (VPSA) was modeled, and the performances of the VPSA process using zeolite 13X, carbon molecular sieve (CMS) and AC were compared.RESULTSThe simulations showed that the advantages of AC for CO2 adsorption include relatively high dynamic adsorption capacity and high mass transfer coefficient of CO2 (KLDF,CO2) in AC and consequently relatively high CO2 desorption rates. However, due to the relatively high mass transfer coefficient of CH4 (KLDF,CH4) in AC, the molecular sieving characteristics for CO2 that were estimated from the ratio between KLDF,CO2 and KLDF,CH4 of AC were not significantly higher than that of zeolite 13X and significantly lower than that of CMS (9.85, 8.41 and 20.92 for AC, zeolite 13X and CMS, respectively).CONCLUSIONSThe modeling results predicted that the VPSA process using zeolite, CMS and AC adsorbents gives a biomethane product of around 98%, 97% and 93% CH4, respectively. © 2023 Society of Chemical Industry (SCI).
Visual impairment in mucopolysaccharidosis VI
Authors: Magalhães Augusto Monteiro , Moleiro Ana Filipa , Rodrigues Esmeralda , Castro Sérgio , Fonseca José , Leão‐Teles Elisa 
Published: January 2023

AbstractMucopolysaccharidosis (MPS) VI is a rare genetic disease characterized by deficient activity of N‐acetylgalactosamine 4‐sulfatase, leading to the systemic deposition of glycosaminoglycans. Ocular involvement is classically characterized by progressive corneal clouding, ocular hypertension (OHT), and optic neuropathy. Although corneal clouding can be solved with penetrating keratoplasty (PK), visual impairment usually remains, being frequently attributed to glaucoma. The purpose of this study was to retrospectively describe a series of MPS VI patients with optic neuropathy in order to deepen the knowledge regarding the causes of severe visual impairment among these patients. We present five genetically confirmed clinical cases of MPS VI, treated with enzymatic replacement therapy, and with regular systemic and ophthalmologic follow‐up. Corneal clouding was a common early presenting feature, leading to PK in four patients. During their follow‐up, all patients developed very low visual acuities regardless of corneal grafts outcomes and controlled intraocular pressure (IOP). Furthermore, all patients exhibited optic atrophy and imagiological evidence of significant subarachnoid space enlargement and consequent optic nerve thickness reduction, suggesting compression of the optic nerve in a retro‐ocular location as the cause of optic neuropathy. Although optic neuropathy in MPS VI is commonly attributed to glaucoma due to OHT, by describing a series of five MPS VI patients, we provided evidence that, differently from glaucoma, compression of optic nerve in a retro‐ocular location is crucial for the development of optic neuropathy, at least in some cases. We propose the denomination of posterior glaucoma and suggest it as an important cause of optic neuropathy, leading to severe visual impairment and blindness among these patients.
Inhibition of influenza A virus replication by a marine derived quinolone alkaloid targeting virus nucleoprotein
Authors: Zhang Yang , Xu Wei‐Feng , Yu Yunjia , Zhang Qun , Huang Lianghao , Hao Cui , Shao Chang‐Lun , Wang Wei 
Published: January 2023

AbstractOwing to the emergence of drug resistance and high morbidity and mortality, the need for novel anti‐influenza A virus (IAV) drugs with divergent targets is highly sought after. Herein, a novel quinolone alkaloid (QLA) derived from marine fungus was discovered with broad‐spectrum anti‐IAV activities with low toxicity. Distinct from current anti‐IAV drugs, QLA may block virus replication and viral RNA (vRNA) export from the nucleus by targeting virus nucleoprotein (NP). QLA can block the binding of chromosome region maintenance 1 to nuclear export signal 3 of NP to inhibit the nuclear export of NP and vRNP. QLA may also affect vRNP assembly by interfering with the binding of NP to RNA rather than NP oligomerization. Arg305 and Phe488‐Gly490 may be required for the interaction between QLA and NP, and the binding pocket around these amino acids may be a promising target for anti‐IAV drugs. Importantly, oral administration of QLA can protect the mice against IAV‐induced death and weight loss, superior to the effects of the clinical drug oseltamivir. In summary, the marine derived compound QLA has the potential to be developed into a novel anti‐IAV agent targeting virus NP protein in the future.
Impact of nonalcoholic fatty liver disease status change on antiviral efficacy of nucleos(t)ide analogues in HBeAg‐positive chronic hepatitis B
Authors: Tang Yanhua , Fan Rong , Lan Zhixian , Xie Qing , Zhang Jiping , Liang Xieer , Wang Hao , Tan Deming , Cheng Jun , Chen Shijun , Ning Qin , Bai Xuefan , Xu Min , Chen Xinyue , Niu Junqi , Shi Junping , Ren Hong , Gao Zhiliang , Wang Maorong , Dou Xiaoguang , Hou Jinlin , Sun Jian 
Published: January 2023

AbstractData on the dynamic changes in chronic hepatitis B (CHB) patients with nonalcoholic fatty liver disease (NAFLD) during antiviral therapy are scarce. We aimed to investigate the evolution of NAFLD status change in CHB patients treated with nucleos(t)ide analogues (NAs) and its influence on therapeutic outcomes. This retrospective study included 164 HBeAg‐positive CHB patients from a randomized controlled trial who were treated with NAs for 104 weeks and underwent paired liver biopsies. Histological evaluation was performed at baseline and Week 104. The patients were divided into four groups according to NAFLD status changes. From baseline to Week 104, the overall percentage of CHB patients with concurrent NAFLD increased from 17.1% to 26.2% (p = 0.044). Among them, 7 of 28 patients (25.0%) with NAFLD at baseline showed NAFLD remission at week 104, while 22 of 136 patients (16.2%) without NAFLD at baseline developed new‐onset NAFLD. In subgroup analyses, the new‐onset and sustained NAFLD groups showed significantly lower rates of biochemical response at week 104 as compared to the sustained non‐NAFLD group (77.3% and 57.1% vs. 93.9%, respectively; all p < 0.05), as well as fibrosis improvement (31.8% and 42.9% vs. 69.3%, respectively; all p < 0.05). NAFLD status changes did not influence the virological response, HBeAg seroconversion, and necroinflammation improvement (all p > 0.05). In HBeAg‐positive CHB patients receiving NAs therapy, new‐onset and sustained NAFLD may counteract the benefits of antiviral therapy, reducing the rate of biochemical response and fibrosis improvement.
Immune‐dysregulation in subacute sclerosing panencephalitis: An exploratory case–control study
Authors: Vijayavarman Vijayaragavan , Malhotra Hardeep S. , Rizvi Imran , Kumar Neeraj , Pandey Shweta , Jain Mili , Ali Wahid , Suresh Vinay , Garg Ravindra K. , Jain Amita , Verma Rajesh , Sharma Praveen , Uniyal Ravi 
Published: January 2023

AbstractSubacute sclerosing panencephalitis (SSPE) is a chronic progressive neurological condition caused by a defective measles virus. It is postulated that immune‐dysregulation might result in persistent infection (immune evasion) as well as initiation of autoimmune phenomenon (via natural killer cells) leading to panencephalitis. The primary objective of this case‐control study was to analyse the pattern of immune dysregulation in cases with SSPE. The secondary objective was to assess the correlation between the measured immunological variables and disability/death at 6 months. This was an exploratory case–control study conducted at a tertiary‐care referral‐facility from January 2020 to September 2021. Thirty consecutive patients fulfilling the Dyken's criteria for SSPE and 30 age‐and‐sex‐matched healthy controls were enrolled. Immunological profile constituted by lymphocyte subset analysis, immunoglobulin levels and complement levels were done in all cases and controls. Cases were staged as per Jabbour's system; disability was assessed using the modified Rankin Scale (mRS). Patients with SSPE had a mean age of 14.76 years (±6.9 years). There were 25 males and 5 females; 6.7% cases belonged to Jabbour's first stage, 40% to second stage and 53.3% to third stage. At least 1/4th had evidence of measles vaccination. Levels of absolute lymphocyte count, B‐cells, T cells, helper T‐cells, and cytotoxic T‐cells were significantly higher in cases. IgG, IgM, and IgE levels were significantly higher while IgD levels were significantly lower in cases. At baseline, 13.3% of cases had a mRS score of 0–2 and 86.7% had a score of 3–6; at 6 months 10% had a mRS score 0–2 (favorable outcome) while 90% had a mRS score 3–6 (poor outcome). Higher IgE levels were found to correlate significantly with favorable outcome. Immune‐dysregulation may play a significant role in shaping one's response to measles infection as well as in determining vaccine‐efficacy.
Two‐year impact of COVID‐19 pandemic on hospitalized patients with skin diseases in China
Authors: Pan Jie , Yang Songchun , Chen Xiaozhen , Che Xuanlin , Lin Wenrui , Chen Mingliang , Chen Xiang , Deng Guangtong , Su Juan 
Published: January 2023

AbstractTo investigate the clinical characteristics of skin disorders among hospitalized patients before and during the coronavirus disease 2019 (COVID‐19) pandemic, a retrospective study was conducted based on hospitalized patients with skin diseases from Xiangya Hospital of Central South University, the largest hospital in the south‐central region of China, between January 1, 2018, and December 31, 2021. A total of 3039 hospitalized patients were enrolled in the study, including 1681 patients in the prepandemic group and 1358 patients in the pandemic group. The total number of hospitalized patients in the pandemic group decreased by 19.2%, with an increased proportion of patients over 60 years of age (39.8% vs. 35.8%). Moreover, compared with the prepandemic group, there were decreases in the occurrence of most skin diseases in the pandemic group, but the proportions of keratinolytic carcinoma (6.6% vs. 5.2%), dermatitis (24.0% vs. 18.9%), and psoriasis (18.0% vs. 14.8%) were higher in the pandemic group. In addition, longer hospital stays (β = 0.07, SE = 0.02, P = 1.35 × 10−3) and higher hospital costs (β = 0.06, SE = 0.03, p = 0.031) were found in the pandemic group through general linear models, even after the corresponding adjustment. In summary, the COVID‐19 pandemic has had a lasting impact on patients with skin diseases, with fewer hospitalized patients, increased proportions of older patients, longer hospital stays, and increased hospital costs. These findings will facilitate better preparation for the most effective response to future pandemics.