bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the awareness of the epidemic, mental health status with mobile phone screen use time in Chinese college students during COVID-19 isolation and control
Authors: Fang Min , Ma TengChi , Li HongHong , Han Tuo , Wang JiaJia , Li ZhiLe , Zhou Jing 
Published: February 2023

Objective
This study aimed to investigate the awareness of the epidemic among college students and their mental health as well as to explore the association between their awareness of the epidemic mental health and the daily mobile phone screen use time, in order to provide guidance for the publicity of school epidemic prevention and control knowledge and the psychological counseling of students.

Methods
A cross-sectional design was employed among 780 college students, The Pandemic Fatigue Questionnaire, epidemic prevention and control knowledge and the mental health Scale were used to collect data through an online survey.

Results
1. Awareness rate of the transmission routes and protective measures of COVID-19 among college students is higher when the daily mobile screen use time is 3–7 hours. 2. 21.79% of the 780 college students felt stressed; 24.87% felt anxious; 19.23% showed depression. 3. The scores of each subscale in the daily mobile phone screen use time of 3–7 hours and more than 7 hours were higher, and the scores of each subscale in the group of more than 7 hours were the highest. Further correlation analysis found that the time spent on mobile phone screens was positively correlated with stress, anxiety, and depression scores (r = 0.155, 0.180, 0.182, P<0.01).

Conclusion
During the COVID-19 isolation and control period, college students with different mobile screen usage time have different understandings of the epidemic. Long-term mobile screen use is related to the occurrence of psychological problems such as stress, anxiety, and depression. Therefore, education departments and schools should pay attention to college students’ mobile phone use time to reduce the occurrence of bad psychological state of students.
Characteristics and short- and long-term direct medical costs among adults with timely and delayed presentation for HIV care in the Netherlands
Authors: Popping Stephanie , Versteegh Lisbeth , Nichols Brooke E. , van de Vijver David A. M. C. , van Sighem Ard , Reiss Peter , Geerlings Suzanne , Boucher Charles A. B. , Verbon Annelies ,   on behalf of the ATHENA observational cohort
Published: February 2023

Introduction
In Europe, half of people living with HIV (PLWH) present late to care, with associated higher morbidity and mortality. This study aims to assess short- and long-term costs of HIV-care based on time of presentation and identify other factors contributing to higher costs in the first and fifth year after antiretroviral therapy (ART) initiation.

Material and methods
We included ATHENA cohort data which prospectively includes 98% of PLWH in the Netherlands. PLWH who initiated ART in 2013 were included and followed over five years. PLWH were divided in three categories based on CD4 cell-count at time of ART initiation: timely presentation (CD4>350cells/μL), late presentation (CD4 200-350cells/μL or >350cells/μL with AIDS-defining illness) and very late presentation (CD4<200cells/μL). The total HIV-care cost was calculated distinguishing ART medication and non-ART medication costs (hospitalization, outpatient clinic visits, co-medications, and HIV-laboratory tests).

Results
From 1,296 PLWH, 273 (21%) presented late and 179 (14%) very late. Nearly half of those who entered HIV-care in a very late stage were of non-Dutch origin, with 21% originating from sub-Saharan Africa. The mean cost per patient in the first year was €12,902 (SD€11,098), of which about two-thirds due to ART (€8,250 (SD€3,142)). ART costs in the first and fifth year were comparable regardless of time of presentation. During the first year on treatment, non-ART medication costs were substantially higher among those with late presentation (€4,749 (SD€8,009)) and very late presentation (€15,886 (SD€ 21,834)), compared with timely presentation (€2,407(SD€4,511)). Higher non-ART costs were attributable to hospitalization and co-medication. The total non-ART costs incurred across five years on treatment were 56% and 246% higher for late and very late presentation respectively as compared to timely presentation.

Conclusion
Very late presentation is associated with substantial costs, with non-ART costs nearly seven times higher than for those presenting timely. Hospitalization and co-medication costs are likely to continue to drive higher costs for individuals with late presentation into the future. Programs that identify individuals earlier will therefore likely provide significant short- and long-term health cost savings.
Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis
Authors: Fu Ningning , Miao Mengrong , Li Ningning , Zeng Shuang , Zhu Ruilou , Zhang Jiaqiang 
Published: February 2023

Background
Now the occurrence of delirium is more concerning to clinicians and psychiatrists. It has been reported that vitamin D deficiency may be a relevant factor in the development of delirium in hospitalized patients.

Study objective
To investigate the association between vitamin D concentration and delirium in hospitalized patients.

Design
Meta-analysis.

Methods
A systematic literature search was conducted using PubMed, EMBASE, and the Cochrane Library. The primary outcome was the occurrence of delirium in the inpatient setting. Odds ratios (OR) were calculated with random or fixed effects models.

Results
In this article, we define the normal range of vitamin D concentrations as greater than 75 nmol / L, 50–75 nmol / L as vitamin D insufficiency, 25–50 nmol / L as vitamin D deficiency, and less than 25 nmol / L as vitamin D severe deficiency. The Results showed that severe vitamin D deficiency (OR: 1.98 [1.41–2.79], P<0.001) and vitamin D deficiency (OR: 1.50 [1.12–2.00], P = 0.006) were more likely to develop delirium than normal vitamin D levels. Subgroup analysis also revealed that low vitamin D concentrations were associated with a higher incidence of delirium, whether the cutoff point was 25 nmol/L (OR: 1.52 [1.40–1.64], P<0.001), 50 nmol/L (OR: 1.47 [1.19–1.82], P<0.001), or 75 nmol/L (OR: 1.54 [1.21–1.96], P<0.001). The included studies scored medium and high on the Newcastle-Ottawa quality assessment scale.

Conclusion
Compared with normal vitamin D levels, severe vitamin D deficiency and vitamin D deficiency, but not vitamin D insufficiency, are associated with a higher incidence of delirium in hospitalized patients.

Trial registration
This review was registered in the PROSPERO database under identifier CRD42021271347. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271347.
Acceptability and feasibility of using contingency management for cannabis reduction in specialist mental health services for psychosis: A qualitative study of staff views
Authors: Middleton Curran Laura , Sheridan Rains Luke , Taylor Jo , Morant Nicola , Johnson Sonia 
Published: February 2023

Aim
There is increasing evidence linking cannabis use to onset, continuation, and relapse of psychosis. Contingency Management (CM) is discussed as a candidate intervention to reduce cannabis use. Our study aimed to explore staff views on the feasibility and acceptability of using CM for cannabis reduction in early intervention services for psychosis (EIS), in order to inform wider learning about implementation of such approaches in mental health services.

Setting
EIS teams in England.

Method
Semi-structured interviews and focus groups analysed thematically.

Participants
Forty managers and staff members working in mental health services where a CM intervention was delivered as part of a trial, four staff who delivered CM in these settings, and three key informants (academic experts in relevant fields).

Intervention
A complex intervention comprising CM with incremental financial incentives (vouchers) for reducing or stopping cannabis use, and psychoeducation about the risks of cannabis use.

Findings
Acceptability appeared to depend on how well the intervention was seen to fit with the service setting and ethos. Concerns included who should deliver CM; potential impacts on the therapeutic relationship; the ethics of using incentives to reduce socially objectionable behaviours; and how CM fits with the work of mental health practitioners. Feasibility concerns centred on resource limitations including time, cost, training, and national guidance and commissioning.

Conclusions
Staff attitudes are likely to be a crucial influence on successful implementation of contingency management for cannabis reduction in specialist mental health settings. Several contextual barriers would need to be overcome to increase the acceptability of the intervention for use in early intervention services for psychosis.
Combinations of medicines in patients with polypharmacy aged 65–100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions
Authors: Fahmi Ali , Wong David , Walker Lauren , Buchan Iain , Pirmohamed Munir , Sharma Anita , Cant Harriet , Ashcroft Darren M. , van Staa Tjeerd Pieter 
Published: February 2023

Background
Polypharmacy can be a consequence of overprescribing that is prevalent in older adults with multimorbidity. Polypharmacy can cause adverse reactions and result in hospital admission. This study predicted risks of adverse drug reaction (ADR)-related and emergency hospital admissions by medicine classes.

Methods
We used electronic health record data from general practices of Clinical Practice Research Datalink (CPRD GOLD) and Aurum. Older patients who received at least five medicines were included. Medicines were classified using the British National Formulary sections. Hospital admission cases were propensity-matched to controls by age, sex, and propensity for specific diseases. The matched data were used to develop and validate random forest (RF) models to predict the risk of ADR-related and emergency hospital admissions. Shapley Additive eXplanation (SHAP) values were calculated to explain the predictions.

Results
In total, 89,235 cases with polypharmacy and hospitalised with an ADR-related admission were matched to 443,497 controls. There were over 112,000 different combinations of the 50 medicine classes most implicated in ADR-related hospital admission in the RF models, with the most important medicine classes being loop diuretics, domperidone and/or metoclopramide, medicines for iron-deficiency anaemias and for hypoplastic/haemolytic/renal anaemias, and sulfonamides and/or trimethoprim. The RF models strongly predicted risks of ADR-related and emergency hospital admission. The observed Odds Ratio in the highest RF decile was 7.16 (95% CI 6.65–7.72) in the validation dataset. The C-statistics for ADR-related hospital admissions were 0.58 for age and sex and 0.66 for RF probabilities.

Conclusions
Polypharmacy involves a very large number of different combinations of medicines, with substantial differences in risks of ADR-related and emergency hospital admissions. Although the medicines may not be causally related to increased risks, RF model predictions may be useful in prioritising medication reviews. Simple tools based on few medicine classes may not be effective in identifying high risk patients.
Impact of Chronic Kidney Disease on Outcomes of Percutaneous Coronary Intervention in Patients With Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Jiang Wei , Zhou Yudi , Chen Shu , Liu Shengxin 
Published: February 2023

Abstract

Background
The impact of chronic kidney disease (CKD) on adverse cardiovascular outcomes after percutaneous coronary intervention in patients with diabetes mellitus (DM) is still unclear. This study aimed to systematically assess evidence on this topic.

Methods
The PubMed, Embase, and CENTRAL databases were searched for studies comparing mortality, myocardial infarction (MI), or revascularization outcomes between patients with DM with and without CKD.

Results
In 11 studies, the presence of CKD was associated with significantly increased risk of early all-cause mortality (risk ratio [RR], 3.45; 95% CI, 3.07–3.87; I2 = 0%; P < .001), late all-cause mortality (RR, 2.78; 95% CI, 1.92–4.02; I2 = 83%; P < .001), cardiac mortality (RR, 2.90; 95% CI, 1.99–4.22; I2 = 29%; P < .001), and MI (RR, 1.40; 95% CI, 1.06–1.85; I2 = 13%; P = .02) compared with no CKD. There was no difference in the risk of any revascularization between those with and without CKD. Analysis of adjusted hazard ratios (HRs) indicated significantly increased risk of mortality (HR, 2.64; 95% CI, 1.91–3.64; I2 = 0%; P < .001) in the CKD group but only a nonsignificant tendency of increased MI (HR, 1.59; 95% CI, 0.99–2.54; I2 = 0%; P = .05) and revascularization (HR, 1.24; 95% CI, 0.94–1.63; I2 = 2%; P = .12) in the CKD group.

Conclusion
The presence of CKD in patients with DM significantly increases the risk of mortality and MI. However, CKD had no impact on revascularization rates.
Surface plasmon resonance assays for the therapeutic drug monitoring of infliximab indicate clinical relevance of anti-infliximab antibody binding properties
Authors: Grasmeier Melina K. , Weber Susanne , Treiber Matthias , Thaler Markus A. , Luppa Peter B. 
Published: February 2023

Abstract

Objectives
The therapeutic antibody infliximab (IFX) has improved the life quality of numerous autoinflammatory disease patients. However, IFX can trigger the generation of anti-drug antibodies (ADA), whose optimal evaluation and management are currently subject of controversial discussions. We present two novel surface plasmon resonance (SPR) biosensor assays for therapeutic drug monitoring of IFX and characterization of ADA and investigated the diagnostic value of ADA binding properties.

Methods
IFX and ADA were quantified via developed SPR biosensor assays (IFXmon and ADAmon, respectively) and diagnostics-approved ELISA in sera from inflammatory bowel disease patients. Pre-analytic ADA enrichment with magnetic beads enabled analytical drug tolerance of the ADAmon assay. The dissociation ratio (DissR) as an index for ADA:IFX binding stability was calculated from the SPR sensorgrams of ADA quantification runs.

Results
IFX levels determined by IFXmon assay and ELISA showed high agreement, whereas ADA quantification concordance between ADAmon assay and ELISA was poor. In patients, DissR was predominantly constant over time and differed significantly between therapy outcomes. A DissR cut-off of 1.524 indicated undetectable IFX levels with 71.4% sensitivity and 88.9% specificity. Additionally, the SPR reference surface was exploited as serum-individual negative control to check result plausibility within multi-sample run sequences.

Conclusions
Overall, both SPR biosensor assays exhibited reliable quantitative performance with accuracies superior to their ELISA counterparts and precision inferior to ELISA only for ADAmon. DissR presented itself as promising ADA binding parameter and could contribute to both earlier and more tailored therapeutic decisions.
Crossing the chasm: strategies for digital transformation in clinical laboratories
Authors: Gungoren Merve Sibel 
Published: February 2023

Abstract
Total testing process in a clinical laboratory is designed to produce useful information for patients and clinicians. The changing landscape of healthcare industry forces clinical laboratory leaders to meet the needs of their stakeholders, maximize operational efficiency and improve overall quality of patient care at the same time. The increasing number of data produced force healthcare services industry to digital transformation.
Digital transformation is a process of change which includes finding solutions to novel and unmet requirements of an industry by integrating information, computing, communication and connectivity technologies to minimize the number of low-value tasks and focus on high-value tasks. As the process of digital transformation includes not only the modernization of IT infrastructure but also a paradigm shift in perception of value creation and delivery to improve the quality and cost-effectiveness of laboratory operations in the long run, financial, managerial, and educational issues have been blocking the widespread implementation.
Clinical laboratories are at the crossroads on the road to the future. Laboratories that fail to align themselves with data-driven practices will risk losing a competitive advantage. In this review, strategies for a successful digital transformation will be overviewed in the context of clinical laboratory settings.
On the order of approximation by modified summation-integral-type operators based on two parameters
Authors: Mohiuddine Syed Abdul , Singh Karunesh Kumar , Alotaibi Abdullah 
Published: February 2023

Abstract
In this article, we the study generalized family of positive linear operators based on two parameters, which are a broad family of many well-known linear positive operators, e.g., Baskakov-Durrmeyer, Baskakov-Szász, Szász-Beta, Lupaş-Beta, Lupaş-Szász, genuine Bernstein-Durrmeyer, and Pǎltǎnea. We first find direct estimates in terms of the second-order modulus of continuity, then we find an estimate of error in the Ditzian-Totik modulus of smoothness. Then we discuss the rate of approximation for functions in the Lipschitz class. Furthermore, we study the pointwise Grüss-Voronovskaja-type result and also establish the Grüss-Voronovskaja-type asymptotic formula in quantitative form.
MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2
Authors: Li Tieqi , Zhang Gehou , Li Wei , Xiao Jian , Zhou Zheng , Tan Guolin , Ai Jingang 
Published: February 2023

Abstract
This study aims to explore the mechanism of microRNA (miR)-101-3p-mediated SOX2/ZIC5 axis in the progression of cisplatin resistance of nasopharyngeal carcinoma (NPC). ZIC5 expression was analyzed with a bioinformatics database and detected in NPC cell lines. Cisplatin-resistant cells (HNE-1/DDP and C666-1/DDP) were transfected with sh-ZIC5, sh-SOX2, sh-SOX2 + pcDNA3.1-ZIC5, or miR-101-3p Agomir + pcDNA3.1-SOX2. MiR-101-3p, SOX2, and ZIC5 expression was assessed after transfection, and cancer associated phenotypes were evaluated after cisplatin treatment. The potential relationships among miR-101-3p, SOX2, and ZIC5 were analyzed. A xenograft mouse model of NPC was established with HNE-1 cells stably transfected or not transfected with oe-ZIC5 and subjected to tail vein injection of miR-101-3p Agomir and intraperitoneal injection of cisplatin. Overexpression of ZIC5 was found in cisplatin-resistant NPC cells. Downregulating ZIC5 in NPC cells decreased cell viability, promoted apoptosis, and reduced cisplatin resistance. SOX2 had a binding site on ZIC5, and SOX2 promoted proliferation, migration, and cisplatin resistance and inhibited cell apoptosis by up-regulating ZIC5. Mechanistically, miR-101-3p was decreased in cisplatin-resistant NPC cells and negatively targeted SOX2. Overexpression of miR-101-3p inhibited tumor growth and cisplatin resistance in xenograft mouse model, which was reversed by ZIC5 overexpression. In conclusion, the miR-101-3p/SOX2/ZIC5 axis was implicated in cancer associated phenotypes and cisplatin resistance in NPC.
Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder’s lung
Authors: Li Yafang , Lian Zhichuang , Li Qifeng , Ding Wei , Wang Wenyi , Zhang Ling , Muhataer Xirennayi , Zhou Yuan , Yang Xiaohong , Wu Chao 
Published: February 2023

Abstract
This study investigated the molecular mechanisms underlying the involvement of the Notch signaling pathway and autophagy in the development of pulmonary fibrosis in pigeon breeder’s lung (PBL). Rats were divided into control (Ctrl), PBL model (M), M + D (Notch signaling inhibition), M + W (autophagy inhibition), and M + R (autophagy induction) groups. Lyophilized protein powder from pigeon shedding materials was used as an allergen to construct a fibrotic PBL rat model. The mechanism by which Notch signaling regulated autophagy in the pulmonary fibrosis of PBL was investigated by inhibiting the Notch pathway and interfering with autophagy. Pulmonary interstitial fibrosis was significantly greater in the M group and the M + W group than in the M + D and M + R groups. The expression of α-smooth muscle actin was significantly higher in the M, M + D, and M + W groups than in the Ctrl group (P < 0.05). The expression of the cell autophagy markers Beclin1 and LC3 was lower in the M, M + D, and M + W groups than in the Ctrl group (P < 0.05), whereas Beclin1 and LC3 expressions were higher in the M + D and M + R groups than in the M group. The levels of reactive oxygen species in serum and lung tissues were higher in the M, M + D, M + W, and M + R groups than in the Ctrl group (P < 0.05). The Notch signaling pathway is involved in the pathological process of pulmonary fibrosis in the rat model of PBL by regulating autophagy.
De Dilma a Bolsonaro: as transformações matriciais na política externa brasileira
Authors: Reis da Silva André Luiz 
Published: February 2023

ResumoEste artigo analisa as transformações recentes na política externa brasileira, a partir da crise política que resultou na destituição da Presidente Dilma Rousseff. Para tanto, analisa o contexto internacional e interno e realiza uma avaliação da política externa dos governos Dilma Rousseff (2011–2016), Michel Temer (2016–2018) e Jair Bolsonaro (a partir de 2019), para os eixos regional, multilateral e bilateral. Utilizando pressupostos de Análise de Política Externa (APE), esta pesquisa analisa simultaneamente os condicionamentos internos e internacionais para a formulação da política externa, identificando atores e interesses. Tem como hipótese de que a política externa brasileira já vinha sofrendo uma crise e reorientação matricial durante o Governo Dilma, baseada na crise política e econômica interna e na transformação das bases internacionais do Brasil, com a fragilização da integração regional e paralisia das negociações multilaterais. As diretrizes da política externa promovida pelo Governo Temer refletiram a conjuntura internacional, a crise brasileira e os interesses de um novo bloco de poder, que procura reorientar a política externa brasileira para uma nova matriz de projeção internacional, mas permaneceu como um período de transição. Já com o Governo Bolsonaro verifica-se uma inflexão matricial na política externa brasileira, com fortes significados internos e internacionais, tendo como principal condicionante a ascensão da direita conservadora.
El Galeón de Manila y el comercio de Asia: Encuentro de culturas y sistemas
Authors: Villamar Cuauhtemoc 
Published: February 2023

ResumenPara tener una perspectiva más clara sobre la importancia de los intercambios económicos y culturales que se realizaron a través del Océano Pacífico a partir del último cuarto del siglo XVI, es fundamental resaltar las interacciones entre culturas y sistemas de intercambio tanto asiáticos como occidentales. En la literatura sobre el Galeón de Manila se tiene al año 1571, fecha en que se fundó Manila como capital de Filipinas, como el punto de inicio de un mecanismo de comercio que mantuvo en constante contacto a ambas orillas del Océano más grande del planeta por dos siglos y medio. En este breve ensayo no es posible hacer una historia detallada de todos los encuentros que se produjeron entre Asia y América española a lo largo de los siglos. En cambio, el lector podrá obtener información sobre algo más sutil, que es el establecimiento de una relación cultural profunda a partir de los intercambios económicos entre Asia, compleja y variada, y las sociedades en el continente americano bajo dominio de la Monarquía española. Me refiero a la etapa inicial de ese encuentro, que dejó una profunda huella cultural, sobre todo por la influencia asiática en la América bajo el dominio español, que comienza a ser revalorada.