bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of periodic wave of a BBM equation with delay convection and weak diffusion
Authors: Wei Minzhi , He Liping 
Published: May 2023

Abstract
This paper focus on the existence and uniqueness of periodic waves for a BBM equation with local strong generic delay convection and weak diffusion. By analyzing the corresponding Hamiltonian system, we aim to obtain the existence of periodic orbit by constructing a locally invariant manifold according to geometric singular perturbation theory. Chebyshev criteria is applied to investigate the ratio of Abelian integrals. We prove the existence and uniqueness of periodic wave solution with sufficiently small perturbation parameter. Moreover, the upper and lower bounds of the limiting wave speed are given.
Mathematics Subject Classification (2020) 34C25 · 34C60 · 37C27
Cross-species application of the lumbar intervertebral disc radiomics model in humans and cynomolgus monkeys
Authors: Gao Manman , Wang Jianmin , Guo Lei , Li Jianfeng , Zhou Jiaxiang , Li Junhong , Li Haizhen , Zhu Zhengya , Tang Tao , Li Xianlong , Wang Wentao , Liu Shaoyu , Zhou Zhiyu , Liu Zhiguo , Xi Yongming 
Published: May 2023

Abstract

Nonhuman primates are ideal animal models for studying intervertebral disc degeneration. Radiomics technology could be used to accurately evaluate intervertebral disc degeneration, which is the basis for disc-related studies. In the study of nonhuman primates, the number of precious animals is limited, which cannot meet the sample size requirements of radiomics for study subjects, while these radiomics models could be obtained more easily in humans. Therefore, it is possible to construct radiomics models based on human intervertebral disc data, and then apply the models to nonhuman primates. However, cross-species application of the radiomics models has not previously been well established in the literature. Here we show that a total of 12.30% (438/3562) of radiomics features are reproducible between humans and cynomolgus monkeys. Furthermore, the human dataset is used as the training set to construct radiomics models, and the cynomolgus monkey’s dataset is used as the testing set to verify the inter species universality of the radiomics models. We found that the radiomics models constructed using human datasets as training sets still has good performance in cynomolgus monkeys. This study provides a theoretical basis for the cross-species application of radiomics model.
The chloroplast nuclear-encoded thioredoxin-like protein HCF164 is predicted to be associated with Coffea SH9 resistance factor against Hemileia vastatrix
Authors: Guerra-Guimarães Leonor , Pinheiro Carla , Oliveira Ana Sofia F. , Mira-Jover Andrea , Valverde Javier , Guedes Fernanda Freitas , Azevedo Herlander , Várzea Vitor , Pajares Antonio Muñoz 
Published: May 2023

Abstract
To explore the connection between chloroplast and coffee resistance factors, designated as SH1 to SH9, the whole genome of 42 coffee genotypes was sequenced and de novo assembled. The chloroplast phylogenetic haplotype network clustered individuals per species instead of SH factors. However, for the first time, it allowed the molecular validation of Coffea arabica as the maternal parent of the spontaneous hybrid Híbrido de Timor (HDT). Individual reads were aligned on the C. arabica reference to relate SH factors with chloroplast metabolism, and an in-silico analysis of selected nuclear-encoded chloroplast proteins (132 proteins) was performed. The nuclear-encoded thioredoxin-like membrane protein HCF164 enabled to discrimination of individuals with and without the SH9 factor, due to specific DNA variants linked to chromosome 7c (inherited from C. canephora). The absence of both the thioredoxin domain and redox-active disulphide center in the HCF164 protein, observed in SH9 individuals, raises the possibility of potential implications on redox regulation. This is the first time that specific DNA variants allow discriminating individuals according to the SH profile. This study introduces an unexplored strategy for identifying protein/genes associated with SH factors and candidate targets of H. vastatrix effectors, thereby creating new perspectives for coffee breeding programs.
Observation of the crossover from quantum fluxoid to half-quantum fluxoid in a chiral superconducting device
Authors: Niimi Yasuhiro , Tokuda Masashi , Nakao Mai , Watanabe Mori , Lee Sanghyun , Nakamura Ryoya , Maeda Masaki , Jiang Nan , Yue Di , Aoyama Kazushi , Mizushima Takeshi , Jin Xiaofeng , Kobayashi Kensuke 
Published: May 2023

Abstract
Topological superconductors are one of the intriguing material groups from the viewpoint of not only condensed matter physics but also elementally particle physics and industrial application such as quantum computers because of the existence of Majorana fermion that is its own antiparticle. For the realization of devices using Majorana fermion, developments of the thin film devices and novel functionalities are highly desirable. Bi/Ni bilayer is a possible candidate for thin-film chiral superconductors where the time-reversal symmetry is broken. Here we report the phase shift of Little-Parks oscillations by half flux quantum φ0/2 in a Bi/Ni ring-shaped device induced by a small magnetic field through the ring. The half quantum fluxoid can be a decisive evidence for unconventional superconductors where the superconducting order parameter has an internal degree of freedom. The present result demonstrates that Bi/Ni is a chiral superconductor with a spin triplet component, and that the internal degree of freedom plays an important role in the phase of supercurrent. The present work also provides a new operating principle for quantum devices where the phase of the supercurrent can be shifted by π with a small magnetic field, based on the internal degree of freedom possessed by topological superconductivity.
Generalizable neuromarker for autism spectrum disorder across imaging sites and developmental stages: A multi-site study
Authors: Itahashi Takashi , Yamashita Ayumu , Takahara Yuji , Yahata Noriaki , Nakamura Motoaki , Aoki Yuta , Aoki Ryuta , Fujino Junya , Ohta Haruhisa , Yoshihara Yujiro , Sakai Yuki , Takamura Masahiro , Ichikawa Naho , Okada Go , Okada Naohiro , Kasai Kiyoto , Tanaka Saori , Imamizu Hiroshi , Kato Nobumasa , Okamoto Yasumasa , Takahashi Hidehiko , Kawato Mitsuo , Yamashita Okito , Hashimoto Ryuichiro 
Published: May 2023

Abstract

Autism spectrum disorder (ASD) is a lifelong condition, and its underlying biological mechanisms remain elusive. The complexity of various factors, including inter-site and development-related differences, makes it challenging to develop generalizable neuroimaging-based biomarkers for ASD. This study used a large-scale, multi-site dataset of 730 Japanese adults to develop a generalizable neuromarker for ASD across independent sites and different developmental stages. Our adult ASD neuromarker achieved successful generalization for the US and Belgium adults and Japanese adults. The neuromarker demonstrated significant generalization for children and adolescents. We identified 141 functional connections (FCs) important for discriminating individuals with ASD from TDCs. Finally, we mapped schizophrenia (SCZ) and major depressive disorder (MDD) onto the biological axis defined by the neuromarker and explored the biological continuity of ASD with SCZ and MDD. We observed that SCZ, but not MDD, was located proximate to ASD on the biological dimension defined by the ASD neuromarker. The successful generalization in multifarious datasets and the observed relations of ASD with SCZ on the biological dimensions provide new insights for a deeper understanding of ASD.
Carious Status and Socio-Behavioral Risk Factors among 12 Year-Old Children in South-Central Region in Romania
Authors: Sfeatcu Ruxandra , Cărămidă Mariana , Sava-Rosianu Ruxandra , Matichescu Marius Lupșa , Galuscan Atena , Dumitrache Mihaela Adina 
Published: May 2023

Abstract
Background Regular screenings at children population level are necessary in order to assess communities’ need for education, prevention, as well as early detection and intervention programs The study aims to assess dental caries experience and oral health-related behaviors among Romania children from the South and Central region.Methods The cross-sectional study conducted in 2019–2020 is part of the national survey “Romanian Oral Health Survey”, under the endorsement of the World Health Organization (WHO). The stratified, randomized and representative sample included 98 children of 12 years of age. The assessment included a clinical examination, using International Caries Detection and Assessment System (ICDAS) and the Oral Health Questionnaire for Children recommended by the World Health Organization.Results Results revealed that the frequency of caries-free children among 12 year-olds was 36.7% and the mean DMFT was 2.89. Regarding the oral health-related habits, 38.8% of children brushed twice daily; the consumption of sugary foods multiple times per day has been frequently met and 11.2% at the age of 12 never visited the dental office.Conclusions The findings revealed that caries prevalence was high and behaviors negatively influence oral health.
Cost comparisons and factors related to cost per stay in intensive care units in Belgium
Authors: Bruyneel Arnaud , Larcin Lionel , Martins Dimitri , Bulcke Julie Van Den , Leclercq Pol , Pirson Magali 
Published: May 2023

Abstract
Background: Given the variability of intensive care unit (ICU) costs in different countries and the importance of this information for guiding clinicians to effective treatment and to the organisation of ICUs at the national level, it is of value to gather data on this topic for analysis at the national level in Belgium. The objectives of the study were to assess the total cost of ICUs and the factors that influence the cost of ICUs in hospitals in Belgium.Methods This was a retrospective cohort study using data collected from the ICUs of 17 Belgian hospitals from January 01 to December 31, 2018. A total of 18,235 adult ICU stays were included in the study. The data set was a compilation of inpatient information from analytical cost accounting of hospitals, medical discharge summaries, and length of stay data. The costs were evaluated as the expenses related to the management of hospital stays from the hospital's point of view. The cost from the hospital perspective was calculated using a cost accounting analytical methodology in full costing. We used multivariate linear regression to evaluate factors associated with total ICU cost per stay. The ICU cost was log-transformed before regression and geometric mean ratios (GMRs) were estimated for each factor.Results The proportion of ICU beds to ward beds was a median [p25-p75] of 4.7% [4.4–5.9]. The proportion of indirect costs to total costs in the ICU was 12.1% [11.4–13.3]. The cost of nurses represented 57.2% [55.4–62.2] of direct costs and this was 15.9% [12.0-18.2] of the cost of nurses in the whole hospital. The median cost per stay was €4,267 [2,050–9,658] and was €2,160 [1,545–3,221] per ICU day. The main factors associated with higher cost per stay in ICU were Charlson score, mechanical ventilation, ECMO, continuous hemofiltration, length of stay, readmission, ICU mortality, hospitalisation in an academic hospital, and diagnosis of coma/convulsions or intoxication.Conclusions This study demonstrated that, despite the small proportion of ICU beds in relation to all services, the ICU represented a significant cost to the hospital. In addition, this study confirms that nursing staff represent a significant proportion of the direct costs of the ICU. Finally, the total cost per stay was also important but highly variable depending on the medical factors identified in our results.
Influencing Factors and Correlation Analysis of Apathy in Patients with Parkinson's Disease
Authors: zhang xuewei , Chen Min , Guo Yanjie , song jingyang , Liu Jiqiang , Tian Linqiang , Kang Lixia , Xing Hongxia 
Published: May 2023

Abstract
Background Parkinson's disease (PD) is a complex progressive neurodegenerative disease. The prevalence of Parkinson's disease has increased rapidly in the last 20 years. Apathy, one of the non-motor symptoms of Parkinson's disease, severely affects patients' daily functioning and quality of life, increases the burden on caregivers, and maybe a precursor to dementia. Identifying the factors associated with indifferent PD patients is essential in slowing disease progression and improving patient prognosis.Methods A total of 73 PD patients from the outpatient or inpatient department of Neurology at the Third Affiliated Hospital of Xinxiang Medical University were collected. The clinical scales of PD patients were assessed. According to Starkstein Apathy Scale (AS), these patients were divided into an apathetic group (46 patients) and a non-apathetic group (27 patients). Spearman correlation analysis and Stepwise multiple linear regression analysis were used to explore the correlation between total AS scores and clinical characteristics.Results Spearman correlation analysis showed that the total scores of AS were positively correlated with disease duration, HY stages, Movement Disorders Society Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS III) scores, Hamilton Anxiety Rating Scale (HAMA) scores, Hamilton Depression Rating Scale (HAMD) scores, Pittsburgh Sleep Quality Index (PSQI) scores, King's Parkinson's Disease Pain Scale ( KPPS) scores, Parkinson Autonomic Symptom Scale (SCOPA-AUT) scores, and 39-item Parkinson's Disease Questionnaire (PDQ-39) scores. It was negatively correlated with Montreal Cognitive Assessment (MoCA) scores and Mini-Mental Status Examination (MMSE) scores. Stepwise multiple linear regression analysis showed that low MoCA scores and high HAMA scores were correlated with apathy, indicating that MoCA scores and HAMA scores may be important determinants of apathy in PD patients.Conclusion PD patients with apathy showed longer disease duration, higher Hoehn and Yahr (HY) stages, more severe motor dysfunction, more severe cognitive impairment, more severe anxiety, more depression symptoms, more severe sleep symptoms, more severe autonomic dysfunction and worse quality of life. Cognitive dysfunction and anxiety may be the risk factors for PD patients with apathy.
The Critical Node of the Transmission of Iron and Steel Technology on the Silk Road in the Han Dynasty: Study on the Iron artifacts from the Han Dynasty Tombs in Xingfucheng, Guyuan, Ningxia Hui Autonomous Region, Northwest China, ca. 202 BC-141 BC
Authors: Zhu Jin , Huang Quansheng , Zou Guisen , Zhu Cunshi , Guo Jialong 
Published: May 2023

Abstract
In the past few decades, many iron artifacts have been excavated in the Ningxia Hui Autonomous Region, which was the critical node that connected the Eastern and Western civilizations on the ancient Silk Road. However, the exploration into the iron and steel metallurgy technology prevalent in Ningxia during that period has been inadequate. In this paper, metallurgical analysis has been conducted on the iron artifacts excavated from the tombs of the early Western Han Dynasty (202-141BC) in Xingfucheng (XFC), Guyuan, Ningxia. Results show that weapons and farming implements were made of decarburized steel and Chaogang. Furthermore, there is evidence of the use of surface carburizing and quenching technologies to control the performance of the iron. In addition, this research also uncovered the utilization of carburized bloomery steel. The iron objects excavated in XFC show traits of bloomery smelting technology from Europe, and Asia, in addition to the steel making techniques found in the Central Plains. Hence, it can be concluded that the iron and steel smelting technology developed in XFC is a result of the confluence of Eastern and Western technologies. The trend of replacing bloomery smelting technology with cast iron appeared in the early Western Han Dynasty, which establishes that Ningxia played an important role in the exchange of ancient metallurgical technology between the East and the West, thus filling the gap of iron archaeometallurgy in Ningxia after the 2nd century BC.
The comparison of corneal higher-order aberration and surgically induced astigmatism between the clear corneal incision and the limbus tunnel incision of posterior chamber implantable collame lens implantation
Authors: Dan Ting-Ting , Liu Tai-Xiang , Luo Hong-yang , Li Zongze , Liao Yi-Lu 
Published: May 2023

Abstract
Background: This study aimed to compare the corneal high-order aberration and surgically induced astigmatism between the clear corneal incision and limbus tunnel incision of posterior chamber implantable collame lens (ICL/TICL) implantation.
Methods :
127 eyes of 73 myopic patients underwent ICL-V4c implantation, 70 eyes underwent clear corneal incisions, and 57 eyes were limbus tunnel incisions. The anterior and back corneal surface of RMS of all higher-order aberration (HOA RMS), spherical aberration(Z40 ), coma coefficients (Coma RMS) Z3-1 Z31, and surgically induced astigmatism (SIA) were collected at preoperative and postoperative one day, one week, and 1, 3, and 6 months. The corneal higher-order aberration was estimated as the Zernike coefficient calculated up to fifth order at a maximum diameter of 6.5 mm using Pentacam.
Results:
After the operation for one week, the corneal back Z31 of the clear corneal incision group was 0.06±0.06 compared to 0.05±0.06 of the limbus tunnel incision group(p=0.031). The corneal back Z40 of the clear corneal incision group was -0.02±0.25 compared to -0.04±0.21 of the limbus tunnel incision group(p=0.01). After the operation one month, the corneal back SIA of the clear corneal incision group was 0.11±0.11 compared to 0.08±0.11of the limbus tunnel incision group (p=0.013), the total corneal SIA of the clear corneal incision group was 0.33±0.3 compared to 0.15±0.16 of the limbus tunnel incision group(p=0.004), the corneal incision has more back astigmatism and total SIA than the limbus tunnel incision in post-operation one month. At post-operation six months, there are no significant differences between the two groups in Z31, Z40 , and other HOA data. The total SIA of the corneal incision group and the limbus tunnel incision group were (0.24±0.14, 0.33± 0.32, p=0.393); there is no significant difference between the two groups after the operation of six months.
Conclusion:
Our data showed that at 6m after ICL-V4c implantation, the high-order aberration and SIA have no significant difference using clear corneal and limbus tunnel incisions.
Proximate composition and antioxidant potentiality of underutilized and neglected edible plants for sustainable development in food security
Authors: Reang Muktadhar , Sarma Dipan , Datta Badal Kumar 
Published: May 2023

Abstract
For decades, indigenous people of rural regions have been consuming wild edible plants as food and medicines. Wild edible plants are neglected and underutilized food plants whose utilization is only restricted to a specific location. It is also referred as Future Smart Foods. Nutritional analysis can provide valuable insights into the potentiality of native wild edible plants as sustainable and nutritious food source. This study aims to analysis the proximate and elemental composition, and antioxidant activity of underutilized and neglected plants in Tripura. In our findings, relatively high carbohydrate, protein and fats content was observed in Oroxylum indicum (13.34±0.29), Trachyspermum roxburghianum (10.43±0.19) and Flacourtia indica (4.25±0.28) respectively. The highest Total energy was recorded in Flacourtia indica (107.97 Kcal). The highest moisture and ash content was observed in Alpinia nigra (94.95%) and Trachyspermum roxburghianum (42.16%) respectively. The quantitative concentration (Wt %) of six micronutrients (Mg, P, K, Ca, Fe and Cl) reveals that the highest was observed in potassium (K) i.e. 34.15% (34.15 mg/gm) in S. pennata. The free radical scavenging activity of the ethanolic extracts showed that L. leucocephala possessed high antioxidant activity (IC50 =125.4±1.78). The nutritional values may be helpful for these underutilized crops to encourage future conservation plans and assess the level of dietary supplement dependency of the local communities. Therefore by promoting the cultivation and consumption of underutilized crops, we can support local communities and accomplish sustainable development in food security.
Lung Transplantation for Pulmonary Graft Versus Host Disease: Experience from a Referral Organ Transplantation Center
Authors: Fakih Riad El , Abdulqawi Rayid , Bugnah Amer , Arabi Tarek , Rasheed Walid , Ezzat Loui , Shaheen Marwan , Chaudhri Naeem , Almohareb Fahad , Mutairy Eid Al , Aljurf Mahmoud D 
Published: May 2023

Abstract
Introduction: Severe pulmonary GvHD after allo-HCT is a significant cause of morbidity and mortality with limited therapeutic options. Selected patients can be lung transplanted, however there are no consensus guidelines on whom to select nor on when to refer.
Method: Retrospective review of patients who underwent LT for lung GvHD after allo-HCT.
Results: Ten patients were identified between January 2002 and December 2020. The median age at LT was 31 years. Seven patients developed aGvHD after allo-HCT and all patients developed cGvHD. The median immunosuppressive lines used before lung transplant was four. The median time between allo-HCT and bronchiolitis obliterans syndrome was 20.5 months. The median time from allo-HCT to LT was 71 months. The median time from first lung transplant evaluation to actual LT was 61 months. The median time from listing for LT to actual LT was 4.8 months. The median FEV1 upon referral to LT clinic was 31% and the median FEV1 upon LT was 25%. All patients received cadaveric bilateral lung transplants. After a median follow up of 4.5 years post-LT, the estimated 5-years OS after LT was 85.7%. The cumulative incidence of CLAD was 50% with a median time from LT to CLAD of 47 months. The CLAD-free survival at 5 years was 50%. Two patients died after developing CLAD complications. No hematologic relapse nor secondary malignancies reported.
Conclusion: LT is an effective intervention for selected lung GvHD patients. Multidisciplinary management and consensus guidelines are needed to better serve these patients.
A Comparative Study of Two Techniques to Avoid Bone Cement Loosening and Displacement after PVP Treating Unstable Kummell's Disease
Authors: Zhang Xinliang , Zhan Yi , Wang Jiangtao , Li Liang , Wang Yuhang , Miao Junxian , Hao Dingjun , Wang Biao 
Published: May 2023

Abstract
Percutaneous vertebroplasty (PVP) is the most common surgical procedure for Kummell's disease (KD), but bone cement loosening or displacement often occurs after the operation. From May 2015 to May 2019, 77 patients who had received PVP-PPP therapy were included in PPP group, and 42 patients who had received PVP-bone cement bridging screw system therapy were included in screw group. The changes in the vertebral body index (VBI), Cobb angle, visual analog scale (VAS) and Oswestry disability index (ODI) and the bone cement loosening and displacement rate at different follow-up time points were used to evaluate the clinical efficacy. Before operation, immediately after operation and at Month 6 after operation, there was no significant difference in VBI or Cobb angle between two groups (P > 0.05), while at Year-1 and Year-2 postoperative evaluations, screw group had higher VBI and Cobb angle than PPP group (P < 0.05). Before operation, immediately after operation, at Month 6 after operation and at Year-1 after operation, there was no significant difference in VAS or ODI score between two groups (P > 0.05), while at Year-2 after operation, screw group had higher VAS and ODI scores than the PPP group (P < 0.05). The rate of bone cement loosening was 14.29% in group PPP, and 0 in screw group (P < 0.05). This two-year follow-up study shows that PVP-bone cement bridging screw system therapy had better treatment efficacy than PVP-PPP therapy, and the bone cement bridging screw system is a preferred therapy with better anti cement loosening ability.