bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factor analysis of omicron patients with mental health problems in the Fangcang shelter hospital based on psychiatric drug intervention during the COVID-19 pandemic in Shanghai, China
Authors: Yu Ping , Bian Xiaolan , Xie Zhihui , Wang Xu , Zhang Xujing , Gu Zhidong , Yang Zhitao , Jing Feng , Qiu Weiyu , Lin Jingsheng , Tang Jie , Huang Chen , Zhang Yibo , Chen Ying , Zhang Zongfeng , Bi Yufang , Shang Hanbing , Chen Erzhen 
Published: February 2023

BackgroundsThe widespread coronavirus disease 2019 (COVID-19) outbreak impacted the mental health of infected patients admitted to Fangcang shelter hospital a large-scale, temporary structure converted from existing public venues to isolate patients with mild or moderate symptoms of COVID-19 infection.ObjectiveThis study aimed to investigate the risk factors of the infected patients from a new pharmacological perspective based on psychiatric drug consumption rather than questionnaires for the first time.MethodsWe summarised the medical information and analysed the prevalence proportion, characteristics, and the related risk factors of omicron variants infected patients in the Fangcang Shelter Hospital of the National Exhibition and Convention Center (Shanghai) from 9 April 2022 to 31 May 2022.ResultsIn this study, 6,218 individuals at 3.57% of all admitted patients in the Fangcang shelter were collected suffering from mental health problems in severe conditions including schizophrenia, depression, insomnia, and anxiety who needed psychiatric drug intervention. In the group, 97.44% experienced their first prescription of psychiatric drugs and had no diagnosed historical psychiatric diseases. Further analysis indicated that female sex, no vaccination, older age, longer hospitalization time, and more comorbidities were independent risk factors for the drug-intervened patients.ConclusionThis is the first study to analyse the mental health problems of omicron variants infected patients hospitalised in Fangcang shelter hospitals. The research demonstrated the necessity of potential mental and psychological service development in Fangcang shelters during the COVID-19 pandemic and other public emergency responses.
Functional connectivity and gray matter deficits within the auditory attention circuit in first-episode psychosis
Authors: Curtis Mark T. , Sklar Alfredo L. , Coffman Brian A. , Salisbury Dean F. 
Published: February 2023

BackgroundSelective attention deficits in first episode of psychosis (FEP) can be indexed by impaired attentional modulation of auditory M100. It is unknown if the pathophysiology underlying this deficit is restricted to auditory cortex or involves a distributed attention network. We examined the auditory attention network in FEP.MethodsMEG was recorded from 27 FEP and 31 matched healthy controls (HC) while alternately ignoring or attending tones. A whole-brain analysis of MEG source activity during auditory M100 identified non-auditory areas with increased activity. Time-frequency activity and phase-amplitude coupling were examined in auditory cortex to identify the attentional executive carrier frequency. Attention networks were defined by phase-locking at the carrier frequency. Spectral and gray matter deficits in the identified circuits were examined in FEP.ResultsAttention-related activity was identified in prefrontal and parietal regions, markedly in precuneus. Theta power and phase coupling to gamma amplitude increased with attention in left primary auditory cortex. Two unilateral attention networks were identified with precuneus seeds in HC. Network synchrony was impaired in FEP. Gray matter thickness was reduced within the left hemisphere network in FEP but did not correlate with synchrony.ConclusionSeveral extra-auditory attention areas with attention-related activity were identified. Theta was the carrier frequency for attentional modulation in auditory cortex. Left and right hemisphere attention networks were identified, with bilateral functional deficits and left hemisphere structural deficits, though FEP showed intact auditory cortex theta phase-gamma amplitude coupling. These novel findings indicate attention-related circuitopathy early in psychosis potentially amenable to future non-invasive interventions.
A randomized, sham-controlled trial of high-definition transcranial direct current stimulation on the right orbital frontal cortex in children and adolescents with attention-deficit hyperactivity disorder
Authors: Wang Yi-chao , Liu Jun , Wu Yan-chun , Wei Yan , Xie Hong-jing , Zhang Tao , Zhang Zhen 
Published: February 2023

ObjectiveThis study aimed to find out the clinical and cognitive effects of high-definition transcranial direct current stimulation (HD-tDCS) on the right orbital frontal cortex (OFC) in the treatment of attention deficit hyperactivity disorder (ADHD).MethodsA total of 56 patients with ADHD were recruited as subjects and completely and randomly divided into the HD-tDCS group and the Sham group. A 1.0 mA anode current was applied to the right OFC. The HD-tDCS group received real stimulation, while the Sham group received sham stimulation in 10 sessions of treatment. ADHD symptom assessment (the SNAP-IV Rating Scale and the Perceived Stress Questionnaire) was carried out before treatment, after the 5th and 10th stimuli, and at the 6th week after the end of all stimulations, while the cognitive effect was assessed by the Integrated Visual and Auditory Continuous Performance Test (IVA-CPT), the Stroop Color and Word Test (Stroop), and the Tower of Hanoi (TOH). Repeated-measure ANOVA was used to find out the results of both groups before and after treatment.ResultsA total of 47 patients completed all sessions and evaluations. Their SNAP-IV score, their PSQ score, the mean visual and auditory reaction times by IVA-CPT, the interference RT of Stroop Color and Word, and the number of completed steps of TOH did not change with intervention time before and after treatment (P &gt; 0.0031). However, the integrated visual and audiovisual commission errors and the TOH completion time results of the HD-tDCS group were significantly decreased after the 5th intervention, the 10th intervention, and the 6th week of intervention follow-up compared to the Sham group (P &lt; 0.0031).ConclusionThis study draws cautious conclusions that HD-tDCS does not significantly alleviate the overall symptoms of patients with ADHD but leads to significant improvements in the cognitive measures of attention maintenance. The study also attempted to fill in the gaps in research studies on HD-tDCS stimulation of the right OFC.Clinical trial registrationChiCTR2200062616.
Knowledge, attitudes, perceptions, and practice toward seasonal influenza and its vaccine: A cross-sectional study from a country of conflict
Authors: Ahmed Wesam S. , Abu Farha Rana , Halboup Abdulsalam M. , Alshargabi Arwa , Al-mohamadi Ahmed , Abu-rish Eman Y. , Zawiah Mohammed , Al-Ashbat Yousf K. , Al-Jamei Sayida 
Published: February 2023

BackgroundThe seasonal influenza vaccine is an important preventive measure against influenza and its associated complications. In Yemen, there is no seasonal influenza vaccination policy, and the influenza vaccine is excluded from the national immunization program. Data on vaccination coverage remain scarce with no previous surveillance programs or awareness campaigns implemented in the country. The current study aims to assess the awareness, knowledge, and attitudes of the public in Yemen toward seasonal influenza and their motivators and perceived barriers to receiving its vaccine.MethodsA cross-sectional survey was carried out using a self-administered questionnaire that was distributed to eligible participants using convenience sampling.ResultsA total of 1,396 participants completed the questionnaire. The respondents showed a median knowledge score of influenza of 11.0/15.0, and most of them (70%) were able to recognize its modes of transmission. However, only 11.3% of the participants reported receiving the seasonal influenza vaccine. Physicians were the respondents' most preferred information source for influenza (35.2%), and their recommendation (44.3%) was the most cited reason for taking its vaccine. On the contrary, not knowing about the vaccine's availability (50.1%), concerns regarding the safety of the vaccine (17%), and not considering influenza as a threat (15.9%) were the main reported barriers to getting vaccinated.ConclusionThe current study showed a low uptake of influenza vaccines in Yemen. The physician's role in promoting influenza vaccination seems to be essential. Extensive and sustained awareness campaigns would likely increase the awareness of influenza and remove misconceptions and negative attitudes toward its vaccine. Equitable access to the vaccine can be promoted by providing it free of charge to the public.
Worldwide trends in prediabetes from 1985 to 2022: A bibliometric analysis using bibliometrix R-tool
Authors: Zhao JingYi , Li Min 
Published: February 2023

BackgroundPrediabetes is a widespread condition that represents the state between normal serum glucose and diabetes. Older individuals and individuals with obesity experience a higher rate of prediabetes. Prediabetes is not only a risk factor for type 2 diabetes mellitus (t2dm) but is also closely related to microvascular and macrovascular complications. Despite its importance, a bibliometric analysis of prediabetes is missing. The purpose of this study is to provide a comprehensive and visually appealing overview of prediabetes research.MethodsFirst, the Web of Science (WOS) database was searched to collect all articles related to prediabetes that were published from 1985 to 2022. Second, R language was used to analyze the year of publication, author, country/region, institution, keywords, and citations. Finally, network analysis was conducted using the R package bibliometrix to evaluate the hotspots and development trends of prediabetes.ResultsA total of 9,714 research articles published from 1985 to 2022 were retrieved from WOS. The number of articles showed sustained growth. Rathmann W was the most prolific author with 71 articles. Diabetes Care was the journal that published the highest number of articles on prediabetes (234 articles), and Harvard University (290 articles) was the most active institution in this field. The United States contributed the most articles (2,962 articles), followed by China (893 articles). The top five clusters of the keyword co-appearance network were “prediabetes”, “diabetes mellitus”, “glucose”, “insulin exercise”, and “oxidative stress”. The top three clusters of the reference co-citation network were “Knowler. WC 2002”, “Tabak AG 2012”, and “Matthews DR1985”.ConclusionsThe combined use of WOS and the R package bibliometrix enabled a robust bibliometric analysis of prediabetes papers, including evaluation of emerging trends, hotspots, and collaboration. This study also allowed us to validate our methodology, which can be used to better understand the field of prediabetes and promote international collaboration.
Assessing capacities and resilience of health services during the COVID-19 pandemic: Lessons learned from use of rapid key informant surveys
Authors: Rivas-Morello Briana , Horemans Dirk , Viswanathan Kavitha , Taylor Chelsea , Blanchard Andrea , Karamagi Humphrey , Droti Benson , Titi-Ofei Regina , Nikiema Laetitia Ouedraogo , Traore Moussa , Kipruto Hillary , del Riego Amalia , Houghton Natalia , Salah Hassan , Alasfoor Deena , Doctor Henry , Tahirukaj Ardita , Tille Florian , Zapata Tomas , O'Neill Kathryn 
Published: February 2023

This article is part of the Research Topic‘Health Systems Recovery in the Context of COVID-19 and Protracted Conflict.’ProblemMany countries lacked rapid and nimble data systems to track health service capacities to respond to COVID-19. They struggled to assess and monitor rapidly evolving service disruptions, health workforce capacities, health products availability, community needs and perspectives, and mitigation responses to maintain essential health services.MethodBuilding on established methodologies, the World Health Organization developed a suite of methods and tools to support countries to rapidly fill data gaps and guide decision-making during COVID-19. The tools included: (1) a national “pulse” survey on service disruptions and bottlenecks; (2) a phone-based facility survey on frontline service capacities; and (3) a phone-based community survey on demand-side challenges and health needs.UseThree national pulse surveys revealed persisting service disruptions throughout 2020–2021 (97 countries responded to all three rounds). Results guided mitigation strategies and operational plans at country level, and informed investments and delivery of essential supplies at global level. Facility and community surveys in 22 countries found similar disruptions and limited frontline service capacities at a more granular level. Findings informed key actions to improve service delivery and responsiveness from local to national levels.Lessons learnedThe rapid key informant surveys provided a low-resource way to collect action-oriented health services data to inform response and recovery from local to global levels. The approach fostered country ownership, stronger data capacities, and integration into operational planning. The surveys are being evaluated to inform integration into country data systems to bolster routine health services monitoring and serve as health services alert functions for the future.
Effects of resourcefulness on internet game addiction among college students: The mediating role of anxiety and the moderating role of gender
Authors: Zhang Yan , Zhong Yun-Ling , Luo Jing , He Jin-Long , Lin Cen , Zauszniewski Jaclene A. , Zhou Jin-Hui , Chen Ying , Wu Chun-Yan , Wang Shu-Rui , Li Zheng-Huan , Tang Jing , Li Wan-Ning , Wu Jing , Luo Jia-Ming 
Published: February 2023

IntroductionThe mechanism of internet game addiction is unclear. Whether anxiety mediates between resourcefulness and internet game addiction and whether gender affect its mediation role have not been studied previously.MethodsA total of 4,889 college students from a college in southwest China were included in this study to complete the investigation, in which three questionnaires were used for evaluation.ResultsPearson's correlation analysis indicated a remarkable negative correlation between resourcefulness with internet game addiction and anxiety, as well as a significant positive correlation between anxiety and this addiction. The structural equation model confirmed the mediation role of anxiety. The multi-group analysis confirmed the moderating role of gender in the mediation model.DiscussionThese findings have advanced the results of existing studies, indicating the buffering effect of resourcefulness on internet game addiction and revealing the potential mechanism of this relationship.
Immune cell population and cytokine profiling suggest age dependent differences in the response to SARS-CoV-2 infection
Authors: Aragon Larraitz , Iribarren-López Andrea , Alberro Ainhoa , Iparraguirre Leire , Von Wichmann Miguel , Marimon Jose María , Saiz-Calderon Nagore , Agudo Julia , Gálvez M. Isabel , Cipitria M. Carmen , Prada Alvaro , Otaegui David 
Published: February 2023

Aging population is at higher risk of developing severe COVID-19, including hospitalization and death. In this work, to further understand the relationship between host age-related factors, immunosenescence/exhaustion of the immune system and the response to the virus, we characterized immune cell and cytokine responses in 58 COVID-19 patients admitted to the hospital and 40 healthy controls of different age ranges. Lymphocyte populations and inflammatory profiles were studied in blood samples, using different panels of multicolor flow cytometry. As expected, our analysis reveals differences at both the cellular and cytokine level in COVID-19 patients. Interestingly, when the age range analysis was carried out, the immunological response to the infection was found to differ with age, being especially affected in the group of 30–39 years. In this age range, an increased exhausted T cell response and a decrease of naïve T helper lymphocytes was found in patients, as well as a reduced concentration of the proinflammatory TNF, IL-1β and IL-8 cytokines. Besides, the correlation between age and the study variables was evaluated, and multiple cell types and interleukins were found to correlate with donor age. Notably, the correlations of T helper naïve and effector memory cells, T helper 1–17 cells, TNF, IL-10, IL-1β, IL-8, among others, showed differences between healthy controls and COVID-19 patients. Our findings, in the context of other previous studies, suggest that aging affects the behavior of the immune system in COVID-19 patients. They suggest that young individuals are able to mount an initial response to SARS-CoV-2, but some of them present an accelerated exhaustion of the cell response and an insufficient inflammatory response, resulting in a moderate to severe COVID-19. On the other hand, in older patients there is a smaller immune cell response to the virus, reflected in fewer differences in immune populations between COVID-19 patients and controls. Nevertheless, old patients show more evidence of an inflammatory phenotype, suggesting that the underlying inflammation associated with their age is exacerbated by the SARS-CoV-2 infection.
Comparing cybersickness in virtual reality and mixed reality head-mounted displays
Authors: Kirollos Ramy , Merchant Wasim 
Published: February 2023

Introduction: Defence Research and Development Canada is developing guidance on the use of Mixed Reality head-mounted displays for naval operations in the Royal Canadian Navy. Virtual reality head-mounted displays display graphics to the user in 3D and completely occlude the user’s view of the real world. Mixed Reality head-mounted displays overlay and integrate graphics onto the real world allowing the user to perceive the real world and rich 3D graphic elements simultaneously. Nausea and other debilitating symptoms caused by the use of head-mounted displays, known as ‘cybersickness’, is well documented during Virtual reality head-mounted display exposure and can be quite severe. However, it is not yet clear from the literature on Mixed Reality head-mounted displays whether CS differs in Virtual reality vs. Mixed Reality head-mounted displays. The objective of this study was to determine the impact of MR HMDs on CS.Method: This was done by modulating the quantity of graphics in two Mixed Reality conditions and one Virtual reality condition. Only foreground objects were graphically rendered in the first Mixed Reality condition (called ‘Mixed Reality’ condition), while the entire scene was graphically rendered in the second Mixed Reality condition (called ‘Mixed Reality +’ condition). The Virtual reality condition simulated the Mixed Reality + condition but was displayed in a Virtual reality head-mounted display. Participants observed the virtually rendered scene in one of the three conditions and reported their CS with the simulator sickness questionnaire six times throughout the 30-min experiment. We hypothesized that CS severity would increase as quantity of graphics in the display increased.Results and Discussion: Findings indicated that CS was significantly greater in the ‘Mixed Reality +’ condition compared to the ‘Mixed Reality’ and ‘Virtual reality’ conditions, providing partial evidence for our main hypothesis. Moreover, CS increased significantly and meaningfully after 25 min in the ‘Mixed Reality +’ condition. These findings indicate safe use of Mixed Reality head-mounted displays by the RCN for shore-based applications provided quantity of graphics is limited.
Oscillatory shear stress promotes vein graft intimal hyperplasia via NADPH oxidase-related pathways
Authors: Yao Guoqing , Li Huanhuan , Zuo Xiangyi , Wang Chunkai , Xiao Yelei , Zhao Yu , Wang Xuehu 
Published: February 2023

BackgroundUncontrolled intimal hyperplasia (IH) after autologous saphenous vein grafting triggers a high restenosis rate; however, its association with the activation of NADPH oxidase (NOX)-related pathways is unclear. Here, we investigated the effects and mechanism of oscillatory shear stress (OSS) on grafted vein IH.MethodsThirty male New Zealand rabbits were randomly divided into control, high-OSS (HOSS), and low-OSS (LOSS) groups, and the vein grafts were harvested after 4 weeks. Hematoxylin and eosin staining and Masson staining assays were used to observe morphological and structural changes. Immunohistochemical staining was used to detect α-SMA, PCNA, MMP-2, and MMP-9 expression. Immunofluorescence staining was used to observe reactive oxygen species (ROS) production in the tissues. Western blotting was used to determine the expression levels of pathway-related proteins (NOX1, NOX2, AKT, p-AKT, and BIRC5), PCNA, BCL-2, BAX, and caspase-3/cleaved caspase-3 in tissues.ResultsBlood flow velocity was lower in the LOSS group than in the HOSS group, while vessel diameter did not change significantly. Shear rate was elevated in both HOSS and LOSS groups but was higher in the HOSS group. Additionally, vessel diameter increased with time in the HOSS and LOSS groups, whereas flow velocity did not. Intimal hyperplasia was significantly lower in the LOSS group than in the HOSS group. IH was dominated by smooth muscle fibers in the grafted veins and collagen fibers in the media. OSS restriction significantly reduced the α-SMA, PCNA, MMP-2, and MMP-9 levels. Moreover, ROS production and the expression of NOX1, NOX2, p-AKT, BIRC5, PCNA, BCL-2, BAX, and cleaved caspase-3 were phase-reduced in LOSS compared to the levels in the HOSS group. Total AKT was not differentially expressed among the three groups.ConclusionOSS promotes the proliferation, migration, and survival of subendothelial vascular smooth muscle cells in grafted veins, which may be related to the regulation of downstream p-AKT/BIRC5 levels through the increased production of ROS by NOX. Drugs inhibiting this pathway might be used to prolong vein graft survival time.
Case Report: Curative effect of OA-PICA protected bypass in severe PICA-complicated vertebral artery stenosis treatment: Results in 3 cases
Authors: Zhao Liming , Xue Bingqian , Guo Gaochao , Wu Ruiyu , Gao Tao , Liu Yang , Sun Yuxue , Hernesniemi Juha , Andrade Barazarte Hugo , Li Tianxiao , Li Chaoyue 
Published: February 2023

ObjectivesWe aimed to explore the results of OA-PICA-protected bypass grafting in patients with severe stenosis of the vertebral artery combined with PICA.MethodsThree patients with vertebral artery stenosis involving the posterior inferior cerebellar artery, treated by the Department of Neurosurgery of Henan Provincial People's Hospital from January 2018 to December 2021, were retrospectively analyzed. All the patients underwent Occipital Artery–Posterior Inferior Cerebellar Artery (OA-PICA) bypass surgery followed by elective vertebral artery stenting. Intraoperative indocyanine green fluorescence angiography (ICGA) showed patency of the bridge-vessel anastomosis. Postoperatively, the ANSYS software was used to assess the flow pressure changes and vascular shear in combination with the reviewed DSA angiogram. CTA or DSA was reviewed 1–2 years postoperatively, and the prognosis was evaluated by the modified Rankin Scale (mRS) one year postoperatively.ResultsOA-PICA bypass surgery was completed in all patients, with intraoperative ICGA showing a patent bridge anastomosis, followed by stenting of the vertebral artery, and a review of the DSA angiogram. We also employed ANSYS software evaluation of the bypass vessel, which showed stable pressure and low turnover angle, suggesting a low rate of long-term occlusion of the vessel. All patients had no procedure-related complications during their hospitalization, and were followed up for a mean of 24 months postoperatively, with a good prognosis (mRS score of 1) at 1 year postoperatively.ConclusionOA-PICA-protected bypass grafting is an effective treatment for patients with severe stenosis of the vertebral artery combined with PICA.