bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Older Indigenous Women Living in High-Income Countries Use Digital Health Technology: Systematic Review
Authors: Henson Connie , Chapman Felicity , Shepherd Gina , Carlson Bronwyn , Rambaldini Boe , Gwynne Kylie 
Published: April 2023

Background
Research associated with digital health technologies similar to the technologies themselves has proliferated in the last 2 decades. There are calls for these technologies to provide cost-effective health care for underserved populations. However, the research community has also underserved many of these populations. Older Indigenous women are one such segment of the population.

Objective
Our objective is to systematically review the literature to consolidate and document what we know about how older Indigenous women living in high-income countries use digital health technology to enhance their health.

Methods
We analyzed the peer-reviewed literature by systematically searching 8 databases in March 2022. We included studies published between January 2006 and March 2022 with original data specific to older Indigenous women from high-income countries that reported on the effectiveness, acceptability, and usability of some user-focused digital health technology. We incorporated 2 measures of quality for each study. We also conducted a thematic analysis and a lived experience analysis, which examined each paper from the perspectives of older Indigenous women. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines in this study.

Results
Three papers met the inclusion criteria. The key findings were that older Indigenous women do not see themselves reflected in mainstream health messaging or other digital health offerings. They prefer an approach that considers their uniqueness and diversity. We also identified 2 significant gaps in the literature. First, research reporting on older Indigenous women from high-income countries’ experiences with digital health technology is minimal. Second, the limited research related to older Indigenous women has not consistently engaged Indigenous people in the research process or governance.

Conclusions
Older Indigenous women want digital health technologies to respond to their needs and preferences. Research is needed to understand their requirements and preferences to ensure equity as we move toward greater adoption of digital health technology. Engaging older Indigenous women throughout the research is essential to ensuring that digital health products and services are safe, usable, effective, and acceptable for older Indigenous women.
Analisis Kesediaan Membayar Terhadap Penggunaan Obat Tradisional pada Masa Pandemi Covid-19 di Masyarakat Dusun Kiringan Desan Canden Bantul
Authors: Hidayati Listiana , Fatimah Fitri Andriani 
Published: April 2023

Infeksi yang disebabkan virus corona maka akan menimbulkan reaksi tubuh. Apabila sistem kekebalan tubuh kuat, virus akan mati dan sistem kekebalan tubuh yang lemah, maka dapat memicu munculnya gejala yang parah dan komplikasi fatal. Imunostimulan dapat meningkatkan mekanisme pertahanan tubuh spesifik dan non-spesifik, dan terdapat induksi non-spesifik dari kedua mekanisme pertahanan seluler dan humoral. Pengobatan tradisional digunakan untuk meringankan gejala COVID-19. Belum ada penelitian yang menunjukkan pengobatan tersebut dapat mencegah atau menyembuhkan penyakit akibat COVID-19. Tujuan penelitian ini untuk mengetahui karakteristik konsumen dan nilai Willingness to Pay (WTP) obat tradisional di Dusun Kiringan. Penelitian ini menggunakan metode deskriptif analitik bersifat non-eksperimental melalui penyebaran kuesioner. Penelitian dilakukan di Dusun Kiringan, Bantul, Yogyakarta dengan metode purposive sampling dengan jumlah sampel sebanyak 276 responden. Data primer dianalisis secara deskriptif dan Contingent Valuation Modelling (CVM). Hasil penelitian menunjukan karakteristik reponden yaitu sebaran menurut usia yaitu 69 responen berusia 36-45 tahun (25%), jenis kelamin perempuan sebanyak 156 (57%), tingkat pendidikan adalah SMA sebanyak 137 responden (50%) dan tingkat pendapatan 172 responden (62%) adalah < Rp 1 juta. Perolehan nilai rataan WTP jahe Rp 19.800, nilai rataan WTP temulawak Rp 11.000, nilai rataan WTP sereh Rp 10.200, Sedangkan nilai rataan WTP kunyit Rp 9.600.
Rasionalitas Regimen Dosis Gentamisin Pada Pasien Rawat Inap Di RSUP Dr. Kariadi Semarang (Kajian Terhadap Efektivitas Terapi Dan Peningkatan Serum Kreatinin)
Authors: Rahmawati Fita , Dilaga Arroyani Asa , Wahyono Djoko 
Published: April 2023

Gentamisin merupakan antibiotik pada terapi empiris khususnya infeksi bakteri gram negatif. Gentamisin memiliki indeks terapi sempit serta bersifat nefrotoksik. Pencegahan nefrotoksisitas dan peningkatan efektivitas terapi gentamisin dapat dilakukan dengan penyesuaikan regimen dosis berdasarkan nilai klirens kreatinin pasien. Penelitian bertujuan mengevaluasi rasionalitas dosis gentamisin serta mengetahui hubungan rasionalitas dosis dengan efektivitas terapi gentamisin dan efek peningkatan serum kreatinin.Penelitian ini menggunakan rancangan cross sectional dilakukan di RSUP Kariadi Semarang. Sejumlah 129 rekam medis pasien rawat inap tahun 2018- 2019 dipilih menggunakan tehnik purpusive sampling. Kriteria inklusi meliputi usia pasien 18 tahun ke atas, menggunakan gentamisin injeksi minimal 3 hari, terdapat data serum kreatinin minimal sebanyak dua kali (sebelum dan sesudah penggunaan injeksi gentamisin). Efektivitas terapi terbagi menjadi membaik dan tidak membaik berdasarkan rekam medis pasien. Peningkatan serum kreatinin ditunjukkan dengan kenaikan sebesar 0,5 mg/dl atau lebih. Statistik bivariat Fisher exact test digunakan untuk mengetahui hubungan kedua variabel.Hasil penelitian menunjukkan dosis rasional terdapat pada 19 (14,73% ) pasien dimana 15 (11,63%) pasien memberikan hasil terapi membaik dan terjadi peningkatan sCr lebih dari 0,5 mg/dl pada 5 (3,88 %) pasien. Sedangkan dosis tidak rasional terdapat pada 110 (85,27%) pasien dimana 52 (40,31%) pasien memberikan hasil terapi membaik dan 31 (24,03%) pasien terjadi peningkatan sCr. Rasionalitas regimen dosis memiliki hubungan signifikan dengan efektitivitas terapi (p<0,05) namun tidak memiliki hubungan signifikan dengan peningkatan serum kreatinin (p>0,05). Peran farmasis diperlukan dalam monitoring terapi pasien sehingga diharapkan dapat meningkatkan optimasi terapi dan menurunkan efek samping.
Analisis Potensi Dampak Perjanjian TRIPs pada Ketersediaan Obat dan Vaksin Covid-19
Authors: Joris Mario Franky , Putri Yuliawan Kadek Maylena , Endarti Dwi 
Published: April 2023

ABSTRAKAdanya perjanjian TRIPs membuat aksesibilitas obat dan pelayanan kesehatan menjadi terhambat karena dibatasi oleh adanya paten, terutama pada masa pandemi Covid-19. Studi ini bertujuan untuk menganalisis dampak dari implementasi TRIPs terhadap ketersediaan obat dan vaksin Covid-19 pada beberapa negara selama masa pandemi. Studi ini dilakukan dengan menggunakan metode studi pustaka, dimana dilakukan pencarian literatur menggunakan berbagai macam database dan kata kunci. Hasilnya, dalam pelaksanaan TRIPs, TRIPs menghalangi ketersediaan obat-obatan esensial, terutama di negara berkembang. Maka dari itu, muncul fleksibilitas TRIPs yang dianggap dapat menjadi opsi dan solusi dalam mengatasi aksesibilitas pelayanan kesehatan, terutama obat dan vaksin Covid-19 selama masa pandemi. Dengan adanya fleksibilitas TRIPs, banyak negara dan juga perusahaan farmasi yang memanfaatkan fleksibilitas ini sehingga menjamin ketersediaan obat dan vaksin esensial untuk penanganan pandemi Covid-19. Kata Kunci: Covid-19; fleksibilitas TRIPs; ketersediaan obat; TRIPs; vaksin Covid-19. ABSTRACTThe existence of the TRIPs agreement has hampered the accessibility of drugs and health services because they are limited by the existence of patents, especially during the Covid-19 pandemic. This study aims to analyze the impact of implementing TRIPs on the availability of Covid-19 drugs and vaccines in several countries during the pandemic. This study was conducted using the literature study method, where a literature search was carried out using various databases and keywords. As a result, in the implementation of TRIPs, TRIPs hinder the availability of essential medicines, especially in developing countries. Therefore, the TRIPs flexibility has emerged which is considered to be an option and solution in overcoming the accessibility of health services, especially drugs and Covid-19 vaccines during the pandemic. With the flexibility of TRIPs, many countries as well as pharmaceutical companies are taking advantage of this flexibility to ensure the availability of essential drugs and vaccines for handling the Covid-19 pandemic.Keyword: Covid-19; TRIPs flexibility; drug availability; TRIPs; Covid-19 vaccine.
Pharmacist Experience in Discovering Forged Prescriptions in Pharmacies In the Special Region of Yogyakarta
Authors: Wati Muvita Rina , Oktaviani Istiqomah Dwi , Bin Yahya Ahmad Fahmy , Ardiningtyas Bondan , Widayati Anna Wahyuni 
Published: April 2023

Pharmacies were a source of narcotics and other addictive agents by 2.1% of respondents to a survey conducted by BNN and LIPI in 2019. One way for drug abusers to obtain drugs is to use forged prescriptions. Therefore, the accuracy of pharmacists in prescription's screening is needed to reduce the prevalence of drug abuse. Research on prescription counterfeiting has been carried out in various developed countries, but similar research has never been conducted in Indonesia. This study aims to determine the patterns, characteristics, and experience of pharmacists in the Special Region of Yogyakarta (DIY) pharmacy in responding to counterfeit prescription findings. This research is an observational study with a survey method using a research instrument in the form of a questionnaire. A total of 152 pharmacists in DIY were involved as respondents and filled out questionnaires both online using the Google Form and offline from November to December 2019. The research data were analyzed descriptively. Based on the results of the study, most of respondents 85%) had encountered counterfeit prescriptions. They were identified by the following characteristics, including the doctor's writings that were not the same as usual (60%), the amount of medicine was irrational/added with 'iter' (59%), absence of doctor’s registration number (41%), stamp (44%), and doctor's signature (32%). The most common drug classes written on fake prescriptions include psychotropics, followed by other drug classes, namely drugs that are often abuse, narcotics, antibiotics, and other ethical drugs (misoprostol and levonogestrel). In identifying counterfeit prescriptions, pharmacists need a guideline, training, and coaching. In addition, clear supervision and reporting channels are needed so that prescription counterfeiting can be reported and seriously followed up by involving Indonesian Pharmacist Association (IAI), Health Office (Dinas Kesehatan), and Indonesia Food and Drug Administration (POM).
Effect of Acetic Acid and/or Sodium Hydroxide Treatment towards Characters of Wonosari Natural Zeolite for Hydrotreatment of Castor Oil into Biofuel
Authors: Triyono Triyono , Trisunaryanti Wega , Falah Iip Izul , Rahmi Lailatul 
Published: April 2023

Natural zeolite (ZA) obtained from Wonosari, Indonesia, was treated with acetic acid (ZAA) or NaOH (ZAB), and the combination of both treatments (ZAAB) in order to increase the Si/Al ratio and catalytic performance on hydrotreatment of castor oil. The Si/Al ratio of ZA increased after the combination of acetic acid and NaOH treatment. The change of the Si/Al ratio was observed in the FTIR spectra as the shifting of internal asymmetric stretching vibration of T−O−T at 1032-1100 cm−1. The XRD profile of ZA was maintained after being subjected to treatments, and ZAB exhibited the lowest crystallinity. The surface area of the ZA after treatment is in the order ZAA < ZA < ZAAB < ZAB. The ZAB catalyst having the highest surface area (19.144 m2 g−1) showed the highest catalytic activity on the hydrotreatment of castor oil with a liquid fraction of 55.1 wt.% and selectivity towards the hydrocarbon compounds of 22.40 wt.%.
Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts Using Alginate: Preparation, Biological Activities, and Release
Authors: Pertiwi Andriana Kusuma , Annisa Choirin , Ningsih Zubaidah , Safitri Anna 
Published: April 2023

The bioactive compounds naturally present in plants have great importance due to their biological characteristics. These substances could lose their active characteristics since they are highly unstable. Microencapsulation is one of the techniques to improve stability and protect these compounds. In this work, Ruellia tuberosa L. ethanolic extracts microcapsules were prepared using a freeze-drying method by varying pH, alginate concentration, and stirring time. The encapsulation efficiency (EE), characteristics, alpha-amylase inhibition activity, and release behavior of the microcapsules were investigated. The results highlighted that the highest encapsulation efficiency for the microcapsules was obtained at pH 6, alginate concentration of 1% (w/v), and 30 min of stirring time (51.63% EE). The microcapsules mostly had spherical shapes with a mean diameter of 197.53 μm. The alpha-amylase inhibition assay from microcapsules resulted in the IC50 value of 46.66 ± 0.13 μg/mL, demonstrating high biological activity. The bioactive substances from microcapsules were released during intervals of 30–120 min at pH values of 1.2 and 7.4. Only 3.51% of the bioactive substances were released at pH 1.2 after 120 min, compared to 55.78% at pH 7.4. Overall, this work confirms the possibility of developing plant extracts with preserved biological activity using the produced microcapsules.
Violence, Its Roots, and How to Stop It
Authors: Avny Amos 
Published: April 2023

The Essay opens with the claim that personal Aggression, Violence and Hostility became permanent visitors in our place. This sad situation was the main reason for writing this paper. Along a short historical review, the Author explains the difference between the former well-organized 20th Century and the current Chaotic world perception of the 21st Century. The Author further reminds that the 20th Century contained two World Wars, that killed tens million people and the Cold War, that had divided the world into two large blocs. Further, the essay explains that in this regard the current century is different. No-more big world-wide armed conflicts, but many end-less small disturbing disorders, violent and terror cases. The difference referred also to the personal prominence of the leaders of the wars. The eminence Winston Churchill—the great outstanding leader of the West, Joseph Stalin—the sadist Communist Dictator who killed tenths millions, and Adolf Hitler—the mentally-ill Tyrant of the Nazi regime who was a horrendous, barbaric and murderer of millions. Comparing to these leaders the nowadays villains and terrorists are sick, confused and weak persons who seek recognition. Abstract cut. The Author assumes that criminal Violence and Terror expand at present as result of three reasons: (1) The termination of political debates due to the political parties’ deterioration, (2) A wrong understanding of today’s developments, and (3) an erroneous feeling, about equality that causes much frustrations and lead to wrong expectations. The Author supports countries’ current initiative for fighting against present terrorists by establishing special Polce and Military units, which know the job, professionally and effectively. However, for (a cut) improving the treatment of this sick phenomenon at the future, the Author emphasizes the need to collect reliable information about the relevant population and its personal weaknesses. At the end a six steps therapeutic program is proposed: (a cut), 1) Revealing and Building the Individual’s Inner-self, 2) Pursuing the “Meaning for life” as Life’s Goal, 3) Endorsing Collaboration and Togetherness, 4) Developing and Empowering the Self-esteem, 5) Recognizing and Accepting Social Heterogeneity, and 6) Sharing actively Social Rights and Commitments. Violence and Terrorism are like Malaria mosquitos, small, unseen but very dangerous. Decisiveness, Consistency and Determination are required for successfully eradicate them.
Nationally Recognized Open Door Model
Authors: Oppenheimer Steven 
Published: April 2023

The White House brochure during a US Presidential Award ceremony stated of Oppenheimer: “He has developed an open door model that encourages students of all economic strata and ethnic groups to participate in his research.” The national recognition noted in the title of this paper included:1) a US Presidential Award for science research mentoring, a White House program administered by the National Science Foundation. The White House brochure said that Oppenheimer’s philosophy was that all interested students should be given the opportunity to do research.Research should not be reserved for the elite.2) election as a Fellow of the American Association for the advancement of science (AAAS). A Fellow of the AAAS is defined as a Member whose efforts on behalf of the advancement of science or its application are scientifically or socially distinguished. Specifically of Oppenheimer as a AAAS Fellow it noted for studies on cell surface carbohydrates in morphogenesis and malignancy. And also for award winning programs that bring advances in science to the student3) statewide Trustees Outstanding Professor Award of the 500,000 student California State University system (largest public university system in the United States). Two of about 20,000 faculty are selected for this highest system wide award each year.These honors resulted from an open door student research program, student career outcomes, student co-authored publications and 14 textbooks/textbook editions. Most of all Oppenheimer’s enthusiasm, energy and humor were instrumental in this success. This program is replicable for those with the energy, enthusiasm and motivation to work with many research students. This paper will explore all the components of this program (Note 1-94).
Закономерности природных процессов в развитии градостроительных систем
Authors: Кубецкая Любовь , Кудрявцева Наталия 
Published: April 2023

В статье рассматривается сходство закономерностей формирования природных и градостроительных систем как естественного органического процесса, приводятся примеры зарождения древнейших городов, планировки сёл, систем расселения Европы; анализируются формы развития центричных и линейных градостроительных, перспективных моделей раз­вития и новых подходов к моделированию градостроительных систем с учётом исследований природных процессов и явлений; освещаются сведения о новых направлениях изучения природных процессов и научных экспериментах по использованию закономерностей в инженерной инфраструктуре и дизайне среды, концепции развития и моделировании градостроительных систем, основанных на принципах органического соединения с природой, доказывается необходимость разработки научно обоснованных форм развития градостроительных систем от расселения к поселению, освещаются новые закономерности и генетический код развития градостроительных систем, подобных природным процессам, даются рекомендации по исполь­зованию в архитектурно-градостроительной практике принципов органичной архитектуры и градостроительных систем[1].

[1] Исследование выполнено за счёт средств государственной фундаментальных научных исследований Российской Федерации на долгосрочный период (2021-2030 годы) в рамках Плана фундаментальных научных исследова­ний РААСН и Минстроя России на 2021 год, тема № 2.1.1.1 «Научные основы применения природоподобных технологий при организации современных градостроительных систем»
The Management of Patients With Acute Aortic Syndrome in A Hospital Setting on the Example of an Emergency Hospital
Authors: Yakubov R. A. , Akhmedov U. U. , Sharafutdinov M. R. , Mukhamadeev M. F. 
Published: April 2023

ABSTRACT Today, the issue of the effectiveness of emergency specialized care for patients with acute aortic syndrome (AAS) is extremely relevant in Russian healthcare. Much attention is paid to logistics and management in the AAS. There is a tendency to increase the share of hybrid treatment of aortic pathology due to the rapid development of endovascular technologies in Russian healthcare institutions. This article presents the scheme of logistics at the prehospital stage, perioperative management and options for surgical treatment, including hybrid and endovascular options of AAS. Particular attention is paid to the resolution of the malperfusion syndrome. The main studies were carried out on the basis of SAHI RT Regional Center for Emergency Medical Care.AIM OF STUDY Development of a logistics scheme and tactics for the treatment of patients with acute aortic pathology.MATERIAL AND METHODS This article provides demographic data and incidence statistics. Not only the hospital stage of effective treatment is important, but logistics with routing and anesthesia management as well. Examples of the routing schemes used by us in practice for patients with AAS starting from 2017 are given. Variants of hybrid treatment and resolution of malperfusion syndrome in patients with AAS are shown on the example of clinical cases.CONCLUSION The applied schemes for transporting patients with AAS allowed the optimal treatment strategy to be chosen, where time is of the essence. Proper perioperative management in patients with aortic pathology will allow deaths to be minimized and/or prevented. The options of performed surgical treatment showed a good result, a decrease in mortality. Penn classification, especially in a situation of high perioperative risk, made it possible to predict in-hospital mortality and outcomes of surgical treatment, and also helped choose an adequate treatment strategy
Endovascular Stent Thrombectomy in Patients With Acute Lower Limb Arterial Thrombosis on the Background of COVID-19
Authors: Semyin I. S. , Ivanenko A. N. , Zharova A. S. , Pyatkov V. A. , Bakhtin I. L. , Sobolev G. A. , Kiselev A. D. , Korotkikh A. V. , Kazantsev A. N , Chernykh K. P. 
Published: April 2023

AIM Analysis of the outcomes of endovascular stent thrombectomy in patients with acute arterial thrombosis of the lower extremities on the background of COVID-19.MATERIAL AND METHODS This retrospective study for the period from January 1, 2020 to March 1, 2022 included 34 patients with acute lower limb ischemia who were diagnosed with the novel coronavirus infection SARS-COV-2. Endovascular stent thrombectomy was performed according to the standard technique using a Destination 8F guiding sheath (Terumo), an Advantage 0.014`` guidewire (Terumo), and a Casper stent (Microvention, Terumo) as a stent retriever. In case of fragmentation of thrombotic masses in the guide sheath, manual aspiration of thrombi was performed using a standard 50,0 ml syringe. Self-expanding nitinol stents were implanted in 11 clinical cases.RESULTS Intraoperative bleeding from the puncture site of the artery developed in 14.7% of cases, which required additional manipulation to achieve hemostasis. Every tenth (11.8%) patient developed myocardial infarction, in 2.9% of cases — ischemic stroke. In the hospital postoperative period during the first hours after surgery, 26.5% of patients developed rethrombosis which required re-intervention. In 8.8% of cases, retrombectomy was unsuccessful, and limb amputation was performed. A fatal outcome occurred in 67.6% of cases, which was due to an increase in multiple organ failure and the development of sepsis.CONCLUSION Endovascular stent thrombectomy is characterized by a low risk of rethrombosis and amputation in the context of COVID-19.