bluuebunny/crossref_metadata_2025_split huggingface dataset:
KUALITAS PELAYANAN PUBLIK BIDANG LAYANAN INFORMASI DI KANTOR BERSAMA SAMSAT KABUPATEN SIDOARJO
Authors: Miftakhul Yaen , Utami Dian Arlupi 
Published: December 2022

Pelayanan publik merupakan faktor penting dalam pemenuhan hak-hak masyarakat sebagai warga negara yang berhak menerima standart pelayanan yang baik dan jelas. Penelitian ini bertujuan untuk mendeskripsikan sejauh mana kualitas pelayanan informasi pada Kantor Bersama Samsat Kabupaten Sidoarjo. Metode yang dilakukan menggunakan metode kualitatif dan pendekatan deskriptif dengan teknik pengumpulan data observasi, wawancara, dan dokumentasi dengan enam orang informan yang terdiri dari satu pegawai bagian layanan informasi dan lima orang penerima layanan di Kantor Samsat Kabupaten Sidoarjo. Hasil penelitian menunjukan bahwa kualitas pelayanan publik di bidang layanan informasi yang ada pada Kantor Bersama Samsat Kabupaten Sidoarjo ini dikatakan sudah cukup baik hal ini dapat dilihat dari dimensi bukti langsung (tangibles) menyangkut kelengkapan sarana dan prasarana fasilitas penunjang dan dengan penampilan pegawai yang sopan, baik dan rapi. Keandalan (reliability) dengan pegawai yang memberikan pelayanan secara cepat, segera, dan memuaskan. Daya tanggap (responsivenes) terkait sikap dari pegawai yang tanggap, jaminan (assurance) terkait dengan pegawai yang memberikan rasa aman dan bebas dari resiko, empati menyangkut hubungan komunikasi yang baik antara pegawai dan masyarakat. Kesimpulan penelitian ini masih ditemui permasalahan dalam hal pelaksanaannya yaitu permasalahan pada sumber daya manusia dibagian informasi yang kurang memadai karena hanya ada 2 orang pegawai yang melayani pengambilan nomor antrian, menjawab alur dan pertanyaan setiap pewajib pajak, dan mengentri nomor telepon pewajib pajak guna mendapat SMS himbauan membayar pajak. Saran dari penulis memberikan garis bantu antrian sehingga saat proses pelayanan berlangsung saat pengambilan nomor antriann , orang yag pertama datanglah yang akan dilayani terlebih dahulu.
EFEKTIVITAS PENYALURAN PROGRAM BANTUAN SOSIAL TUNAI (BST) DI MASA PANDEMI COVID-19 DI KELURAHAN KALABBIRANG KECAMATAN PATTALASSANG KABUPATEN TAKALAR)
Authors: Indawati Rahmah 
Published: December 2022

Efektivitas berhasil tidaknya pencapaian tujuan suatu organisasi mencapai tujuan yang sudah ditetapkan di dalam suatu instansi, aktivitas ataupun program. Menurunnya Perekonomian Masyarakat bermula karena adanya pandemi Covid-19. Program Bantuan Sosial Tunai bertujuan untuk meningkatkan kesejahteraan masyarakat dan untuk membantu meringankan perekonomian masyarakat yang terkena wabah pandemi Covid-19. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Data dalam penelitian ini bersumber dari wawancara, dan telaah dokumen. Narasumber berjumlah delapan orang, terdiri dari Pegawai Bidang Fakir Miskin, Lurah Kalabbirang dan Pegawai Bagian Data Kelurahan Kalabbirang serta lima masyarakat penerima Bantuan Sosial Tunai penelitian ini memberikan sembilan pertanyaan kepada instantsi pemerintah terkait indikator efektivitas penyaluran dan lima pertanyaan terhadap pemantauan program BST. Hasil penelitian ini dapat diketahui bahwa efektivitas pelaksanaan program Bantuan Sosial Tunai di masa pandemi Covid-19 di Kelurahan Kalabbirang Kabupaten Takalar efektif dan berjalan sesuai rencana, didukung oleh sejumlah indikator yang telah tercapai ialah ketepatan sasaran program, pencapaian tujuan program serta pemantauan program yang sudah dicapai sesuai rencana. Dinas sosial Kabupaten Takalar dan Kelurahan Kalabirang sudah berperan aktif dalam Program Bantuan Sosial Tunai di kelurahan kalabirang di masa pandemi Covid-19.
LITERATURE OF EMIGRATION. EXPERIENCE OF HISTORICAL PROSE IN THE FIELD OF FOREIGN CULTURE
Authors: Nabytovych Ihor 
Published: December 2022

Historical novel, as a special genre formation born of Romanticism, has become an artistic tool for the reproduction of the past, its discovery and invention. Historical prose is the literary space where two worldview narrative strategies intersect, overlap, and sometimes collide: these are history that (in its academic sense) seeks to recreate the ‘true past’, and literature, which is a particular representation and development of the world. Historical prose of Ukrainian emigration appears as a fairly integral literary and aesthetic phenomenon during two interwar decades of the 20th century and ends at the border of the 1990s — aft er Ukraine gained its independence. For nations that lost their statehood, the return of the past, its glorification is an important means of forming national identity and self-consciousness. The historical novel of the Ukrainian emigration is a relentless attempt to root its next generations in the national tradition of collective memory.
In general, for societies in which the state tradition has been interrupted, historical prose can be an essential factor in restoring / maintaining national memory, as well as a means of creating national myths, projecting the past into modern problems of a stateless nation, and preserving national traditions. The historical prose of the Ukrainian emigration was actually focused on these aims, taking responsibility for the nationalist and philosophic perspective rooted in the past in order to preserve and increase it in the future. The aspiration and experience of Ukrainian emigration in other countries carries a number of tasks that it set for itself. Th ese were, in particular, the preservation of the native language, culture, and creative activity, including historical prose on the themes prohibited in the mainland literature, the formation of the strategy of collective memory through historical prose.
Effect of a targeted pain management protocol for the treatment of dermatitis interdigitalis contagiosa in Merino meat sheep in a tilt squeeze chute
Authors: Rachidi Fanny , Wagner Romy , Fieseler Helena , Kaiser Matthias , Müller Hendrik , Podpečan Ožbalt , Mielenz Norbert , Gottschalk Jutta , Einspanier Almuth , Möbius Gerd , Baumgartner Walter , Starke Alexander 
Published: December 2022

IntroductionThe effect of a targeted pain management protocol consisting of sedation and local anesthesia on the stress response to treatment of dermatitis interdigitalis contagiosa (DINCO) was assessed in sheep placed in dorsal recumbency.MethodsBlood cortisol concentrations were measured once a day (Day -3 to 2) and additionally on day 0, six times during the claw treatment (stress model). Twelve healthy sheep (control group; HEALTHY) and 36 sheep with DINCO, randomly allocated to one of three treatment groups, underwent the stress model with or without pain control: the XYLA-IVRA sheep were sedated with 2% xylazine hydrochloride (XYLA) and received retrograde intravenous regional anesthesia (IVRA); the IVRA sheep underwent IVRA and received a placebo instead of sedation; the PLACEBO sheep received placebos for sedation and IVRA. The HEALTHY sheep underwent sham claw treatment and received placebos.Results and discussionThe cortisol concentrations were higher in sheep restrained in dorsal recumbency compared with the cortisol concentrations measured four hours later in standing sheep (HEALTHY 37.2 ± 3.3 ng/ml vs. 18.5 ± 3.3 ng/ml; DISEASED 34.0 ± 1.9 ng/ml vs. 17.6 ± 1.9 ng/ml; p &lt; 0.001). The stress response of XYLA-IVRA (area under the curve; AUC = 34.9 ± 2.6 ng/ml) was reduced compared with the stress response of PLACEBO (AUC = 48.0 ± 2.6 ng/ml, p &lt; 0.01) and HEALTHY sheep (AUC = 46.6 ± 2.5 ng/ml; p = 0.01). While cortisol concentration of XYLA-IVRA and HEALTHY sheep did not increase one day after the stress model (Day 1) compared with the day of the stress model (Day 0), both PLACEBO (47.4 ± 3.3 vs. 35.6 ± 3.1 ng/ml, p = 0.02) and IVRA sheep (39.1 ± 2.8 vs. 28.6 ± 3.1 ng/ml, p = 0.01) had higher cortisol concentrations. The results confirm that fixation in dorsal recumbency in a tilt squeeze chute was a major stressor in sheep. The differences in the cortisol concentration of the PLACEBO sheep versus the XYLA-IVRA sheep during and after the stress model illustrate the effect and necessity of pain management protocols in practice.
Circulating miR-29b decrease in response to sarcopenia in patients with cardiovascular risk factors in older Chinese
Authors: He Nana , Zhang Yuelin , Zhang Yue , Feng Beili , Zheng Zaixing , Ye Honghua 
Published: December 2022

IntroductionSarcopenia is a clinical syndrome characterized by a progressive and extensive decline in skeletal muscle mass, muscle strength, and function. Sarcopenia and cardiovascular diseases (CVDs) can coexist, which further decreases the quality of life of patients, and increases the mortality rate. MicroRNAs (miRNAs) are unique posttranscriptional regulators of gene expression whose function in aging-related sarcopenia and CVDs has recently begun to unravel. The aim of the present study is to investigate the relationship between sarcopenia and cardiovascular risk factors (CVRF) in the Chinese elderly and describe the circulating miRNAs in sarcopenia patients with the intention of identifying novel diagnostic and therapeutic tools.MethodsThe well-established CVRF of diabetes, hypertension, and dyslipidemia were assessed. Multiple logistic regression analyses and linear regressions were used to evaluate the components of CVRF and the number of CVRF in elderly patients with sarcopenia. Moreover, we used real-time RT-PCR to measure the abundance of the CVRF-related miRNAs in the plasma of a cohort of 93 control and sarcopenia individuals, including miR-29b, miR-181a, and miR-494.ResultsWe found that CVRF was associated with a high prevalence of sarcopenia in elderly Chinese populations After adjusting for potential confounders. Furthermore, hypertension and dyslipidemia, but not diabetes, were found to be significantly associated with sarcopenia. A linear increase in the prevalence of sarcopenia was found to be associated with the number of CVRF components in the elderly population. We found that plasma miR-29b levels were significantly down-regulated in response to sarcopenia in the elderly with CVRF. In particular, there was a remarkable correlation between miR-29b and appendicular skeletal muscle mass (ASM)/height2. Collectively, knowledge of CVRF, particularly hypertension and dyslipidemia, may help predict the risk of sarcopenia in the elderly. Our data also show that circulating miR-29b can be considered as possible biomarkers for sarcopenia, which may also be used in the CVD assessment of these patients.DiscussionWe found that the prevalence of sarcopenia was significantly proportional to the number of CVRF components. In particular, hypertension and dyslipidemia were significantly associated with a higher risk of sarcopenia in the adjusted models. Moreover, our study has been proven that c-miRNAs may be considered as possible biomarkers for sarcopenia as a new diagnostic tool to monitor response to treatment. There is also a pressing need for further research on sarcopenia and CVRF to understand their relationship and mechanism. These can provide more evidence to develop potential interventions to improve clinical outcomes.
Prediction of the invasiveness of PTMC by a combination of ultrasound and the WNT10A gene
Authors: Yan Zhang , Gang Liu Wen , Yan Guo Shi , Zhou Ping 
Published: December 2022

ObjectiveThe purpose of this study was to predict the invasiveness of papillary thyroid microcarcinoma (PTMC) via ultrasonography in combination with the Wnt family member 10A (WNT10A) gene to provide a reference basis for evaluating the invasive capability of PTMC.MethodsCancer tissue were collected from 182 patients with unifocal PTMC, and the patients were divided into the invasive group and the non-invasive group based on whether the lesions invaded the thyroid capsules or whether lymph node metastasis occurred. The expression of WNT10A protein was examined. Age, sex, maximum nodule diameter, color Doppler flow imaging (CDFI), nodule echo, microcalcification, aspect ratio, morphology (boundary), nodule location, internal structure, ultrasound-suspected lymph node metastasis (US-LNM), and WNT10A expression were compared between the invasive group and the non-invasive group. Univariate analysis and multivariate logistic regression analysis were performed, and a p value of less than 0.05 indicated that the difference was statistically significant.Results(1) 36 patients in the non-invasive group showed high expression and 66 patients showed low or no expression, while 54 patients in the invasive group showed high expression and 26 patients showed low or no expression, suggesting that the expression level of WNT10A was higher in the invasive group than in the non-invasive group, with a statistically significant difference between the two groups (P&lt;0.01). (2) Univariate analysis showed that there were statistically significant differences between the invasive PTMC group and the non-invasive group in age, sex, maximum nodule diameter, microcalcification, US-LNM and high WNT10A expression. (3) Multivariate analysis showed that the risk factors for invasiveness in patients with PTMC included age &lt; 45 years, maximum nodule diameter &gt; 7 mm, microcalcification, US-LNM and high WNT10A expression.ConclusionThe risk factors for PTMC invasiveness included age &lt; 45 years, maximum nodule diameter &gt;7 mm, microcalcification, US-LNM and high WNT10A expression. A combination of ultrasonography and WNT10A gene analysis could provide a reference basis for evaluating the invasive capability of PTMC.
Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation
Authors: Pavliuchenko Nataliia , Duric Iris , Kralova Jarmila , Fabisik Matej , Spoutil Frantisek , Prochazka Jan , Kasparek Petr , Pokorna Jana , Skopcova Tereza , Sedlacek Radislav , Brdicka Tomas 
Published: December 2022

IntroductionAutoinflammatory diseases are characterized by dysregulation of innate immune system leading to spontaneous sterile inflammation. One of the well-established animal models of this group of disorders is the mouse strain Pstpip2cmo. In this strain, the loss of adaptor protein PSTPIP2 leads to the autoinflammatory disease chronic multifocal osteomyelitis. It is manifested by sterile inflammation of the bones and surrounding soft tissues of the hind limbs and tail. The disease development is propelled by elevated production of IL-1β and reactive oxygen species by neutrophil granulocytes. However, the molecular mechanisms linking PSTPIP2 and these pathways have not been established. Candidate proteins potentially involved in these mechanisms include PSTPIP2 binding partners, PEST family phosphatases (PEST-PTPs) and phosphoinositide phosphatase SHIP1.MethodsTo address the role of these proteins in PSTPIP2-mediated control of inflammation, we have generated mouse strains in which PEST-PTP or SHIP1 binding sites in PSTPIP2 have been disrupted. In these mouse strains, we followed disease symptoms and various inflammation markers.ResultsOur data show that mutation of the PEST-PTP binding site causes symptomatic disease, whereas mice lacking the SHIP1 interaction site remain asymptomatic. Importantly, both binding partners of PSTPIP2 contribute equally to the control of IL-1β production, while PEST-PTPs have a dominant role in the regulation of reactive oxygen species. In addition, the interaction of PEST-PTPs with PSTPIP2 regulates the production of the chemokine CXCL2 by neutrophils. Its secretion likely creates a positive feedback loop that drives neutrophil recruitment to the affected tissues.ConclusionsWe demonstrate that PSTPIP2-bound PEST-PTPs and SHIP1 together control the IL-1β pathway. In addition, PEST-PTPs have unique roles in the control of reactive oxygen species and chemokine production, which in the absence of PEST-PTP binding to PSTPIP2 shift the balance towards symptomatic disease.
Association between first 24-h mean body temperature and mortality in patients with diastolic heart failure in intensive care unit: A retrospective cohort study
Authors: Xu Hongyu , Xie Yonggang , Sun Xiaoling , Feng Nianhai 
Published: December 2022

BackgroundBody temperature (BT) has been used to evaluate the outcomes of patients with various diseases. In this study, patients with diastolic heart failure (DHF) in the intensive care unit (ICU) were examined for a correlation between BT and mortality.MethodsThis was a retrospective cohort study of the Medical Information Mart for Intensive Care (MIMIC)-IV dataset. A total of 4,153 patients with DHF were included. The primary outcomes were 28-day ICU and higher in-hospital mortality rates. BT was used in the analyses both as a continuous variable and as a categorical variable. According to the distribution of BT, the patients were categorized into three groups (hypothermia BT &lt;36.5°C, normal 36.5°C ≤ BT &lt;37.5°C, and hyperthermia BT ≥37.5°C). Multivariate logistic regression analysis was performed to explore the association between BT and patient outcomes.ResultsThe proportions of the groups were 23.6, 69.2, and 7.2%, respectively. As a continuous variable, every 1°C increase in BT was associated with a 21% decrease in 28-day ICU mortality (OR: 0.79, 95% CI: 0.66–0.96, and p = 0.019) and a 23% decrease in in-hospital mortality (OR: 0.77, 95% CI: 0.66–0.91; and p = 0.002). When BT was used as a categorical variable, hypothermia was significantly associated with both 28-day ICU mortality (OR: 1.3, 95% CI: 1.03–1.65; and p = 0.026) and in-hospital mortality (OR: 1.31, 95% CI: 1.07–1.59; and p = 0.008). No statistical differences were observed between 28-day ICU mortality and in-hospital mortality with hyperthermia after adjustment.ConclusionThe first 24-h mean BT after ICU admission was associated with 28-day ICU and in-hospital mortality in patients with DHF. Hypothermia significantly increased mortality, whereas hyperthermia did not.
Residual inflammation in psoriatic arthritis patients in stable minimal disease activity
Authors: Macchioni Pierluigi , Marchesoni Antonio , Ciancio Giovanni , Sandri Gilda , Zabotti Alen , Vukatana Gentiana , Montaguti Luca , Focherini Mariacristina , Govoni Marcello , Spinella Amelia , Malavolta Nazzarena , Zuliani Francesca , Bruschi Marco , Mascella Fabio , Salvarani Carlo 
Published: December 2022

BackgroundIn psoriatic arthritis (PsA), low disease activity as defined by the Minimal Disease Activity (MDA) index is considered a good treatment target. However, as MDA is based only on clinical findings, it might not capture pauci-symptomatic inflammation. Sensitive imaging such as ultrasound (US) might disclose residual inflammatory signs in PsA patients in MDA.MethodsIn this cross-sectional multicentre study, adult PsA patients on biologic treatment in MDA for at least 6 months were consecutively enrolled for a thorough clinical and US examination. Data collection included demographics, personal history, main patient's reported outcomes, clinical and US findings of joints, tendon sheaths, tendons, bursae, and entheses involvement. All centers performed the US investigation in B-mode and Power Doppler (PD)-mode using a similar US machine equipped with a 18–6 and 13–5 MHz multifrequency linear probe. Statistical analysis included comparisons between groups and correlation tests.ResultsThe 72 PsA patients enrolled in the study had a median duration of MDA of 12 (6–65) months. Overall, US examination revealed a low number of acute lesions. However, 54% of patients had at least one PD signal in the examined tissues. A joint or enthesis positive PD signal was found in about 19 and 24% of patients, respectively. Synovial hypertrophy, at least one acute entheseal lesions, and bursitis were the most common changes, detected in 41.7, 41.7 and 26% of patients, respectively.ConclusionsPsA patients in a stable state of MDA may still have residual inflammation in peripheral articular structures detectable by US examination.
Specific high-resolution scheme to improve understanding of the spatio-temporal dispersion of lymphogranuloma venereum epidemic
Authors: Martínez-García Laura , González-Alba José María , Puerta Teresa , Comunión Alicia , Rodríguez-Jiménez María Concepción , Orviz Eva , Sánchez-Conde Matilde , Rodríguez-Domínguez Mario , Cantón Rafael , Galán Juan Carlos 
Published: December 2022

IntroductionLymphogranuloma venereum (LGV) is already endemic in vulnerable populations in several European countries; however, molecular epidemiology data with improved accuracy are necessary to better understand LGV epidemic in these countries. Current strategies to study the molecular epidemiology of LGV cases involve schemes based on a few genetic fragments of Chlamydia trachomatis, which have demonstrated limited discriminatory power for LGV. Therefore, this study aimed to propose a new combination of molecular markers based on the most variable genes of L-genotype genomes to improve the characterization of the current LGV epidemic in Madrid, Spain.MethodsFour genes were selected according to their diversity index (CTLon_0054, CTLon_0087, CTLon_0243 and CTLon_0301) for use in combination with ompA. In silico and experimental studies were performed to compare the previously described multilocus sequence typing (MLST) schemes with our proposal. Moreover, the proposed scheme was applied (n = 68) to analyze the spatio-temporal spread of the LGV cases.ResultsOur proposal demonstrated higher diversity allowing the identification of three main groups compared to the previously published MLST based on hypervariable genes wherein only a single sequence type was identified. The temporal analysis showed that the major cluster was progressively diversifying, revealing a very active transmission chain. Furthermore, an L2b genome identical to that of the origin of the epidemic was detected, suggesting reintroductions or a low screening rate in vulnerable populations. The spatial distribution suggests that the selection and spread of new variants occurs from the central district to the peripheral regions.DiscussionThe scheme proposed in this study has proven to be useful for appropriate discrimination of LGV strains. This study, to our knowledge for the first time, demonstrates a spatio-temporal spread that increases our understanding and identifies areas with special susceptibility for maintenance of the endemic situation of LGV.
A brain-inspired robot pain model based on a spiking neural network
Authors: Feng Hui , Zeng Yi 
Published: December 2022

IntroductionPain is a crucial function for organisms. Building a “Robot Pain” model inspired by organisms' pain could help the robot learn self-preservation and extend longevity. Most previous studies about robots and pain focus on robots interacting with people by recognizing their pain expressions or scenes, or avoiding obstacles by recognizing dangerous objects. Robots do not have human-like pain capacity and cannot adaptively respond to danger. Inspired by the evolutionary mechanisms of pain emergence and the Free Energy Principle (FEP) in the brain, we summarize the neural mechanisms of pain and construct a Brain-inspired Robot Pain Spiking Neural Network (BRP-SNN) with spike-time-dependent-plasticity (STDP) learning rule and population coding method.MethodsThe proposed model can quantify machine injury by detecting the coupling relationship between multi-modality sensory information and generating “robot pain” as an internal state.ResultsWe provide a comparative analysis with the results of neuroscience experiments, showing that our model has biological interpretability. We also successfully tested our model on two tasks with real robots—the alerting actual injury task and the preventing potential injury task.DiscussionOur work has two major contributions: (1) It has positive implications for the integration of pain concepts into robotics in the intelligent robotics field. (2) Our summary of pain's neural mechanisms and the implemented computational simulations provide a new perspective to explore the nature of pain, which has significant value for future pain research in the cognitive neuroscience field.