bluuebunny/crossref_metadata_2025_split huggingface dataset:
Of Public Satisfaction In Public Services Investment Department And One Stop Services (Dpmptsp) Bengkulu Province
Authors: Yogi alfiansyah  
Published: September 2023

The problem is the lack of optimal implementation of licensing services based on one-door integrated services, so that it affects people's satisfaction. It can be seen that the implementation of services does not feel easy both in terms of service procedures that are still not understood by the community, facilities and infrastructure that are not maximally adequate. Based on the research results, it can be concluded that the implementation of licensing and non-licensing services in general is going well, but with a note that there are still several elements that have not made the community feel satisfied. In the service provided by DPMPTSP Bengkulu Province, the community really appreciates the free service fee, the officers who are very competent in their field, the friendliness of the officers who provide services, the requirements are quite understandable. However, the community is dissatisfied with the speed of the service provided and also regarding procedures that are not understood by some of the people who are applicants for permits. In addition, there are factors that influence the services provided by DPMPTSP Bengkulu Province, including service implementing apparatus, service facilities and infrastructure and bureaucratic structure.
Keyword: service, stratification, community
Pengaruh Model Pembelajaran Problem Based Learning Terhadap Hasil Belajar Siswa Kelas XI SMAN 1 Lambitu
Authors: Syahrul Syahrul , Nasir Muh. , Nurfathurrahmah Nurfathurrahmah 
Published: September 2023

Penelitian ini dilakukan untuk mengetahui pengaruh model pembelajaran Problem Based Learning Terhadap Hasil Belajar Siswa pada Kelas XI SMAN 1 Lambitu. Rancangan penelitian menggunakan metode quasi eksperimen dengan desain Post-test Control-group, Populasi yang digunakan adalah siswa kelas XI sebanyak 2 kelas dengan jumlah 24 orang. Siswa tersebut aktif belajar di SMAN 1 Lambitu Tahun pelajaran 2021-2022, Sampel dalam penelitian ini adalah siswa kelas XI semester II sebanyak 1 kelas yang berjumlah 12 orang siswa, satu kelas sebagai kelas eksperimen diterapkan model Problem Based Learning dan satu kelas sebagai kelas kontrol tidak diterapkan model Problem Based Learning. Penelitian ini dilakukan di SMAN 1 Lambitu, penulis mengumpulkan data hasil belajar kognitif ini adalah dengan menggunakan Lembar soal Post-test, Uji hipotesis penelitian menggunakan uji-t dengan bantuan program computer SPSS 14 For windows pada taraf signifikan 5% sebelum uji hipotesis,data terlebih dahulu dilakukan uji prasyarat yaitu uji normalitas dan homogenitas data. Hasil penelitian menunjukan terdapat pengaruh model pembelajaran Problem Based Learning terhadap hasil belajar siswa kelas XI SMAN 1 Lambitu, hasil ini ditunjukan dengan angka signifikan sebesar 0,019 lebih kecil dari 0,05.
Ekstrak Daun Sirsak dan Gamal Terhadap Mortalitas Kumbang Bubuk Benih Jagung
Authors: Berek Maria C.L. , Santiari Made , Atini Blasius 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui persentase mortalitas hama kumbang bubuk, mengetahui LC50 ekstrak daun sirsak, ekstrak daun gamal dan kombinasi ekstrak daun sirsak dan daun gamal dan kombinasi keduanya untuk mematikan hama kumbang bubuk (Sitophilus zeamais M.) dan untuk mengetahui ekstrak daun mana yang paling efektif untuk membunuh hama kumbang bubuk (Sitophilus zeamais M.). Penelitian dilaksanakan pada bulan Juni-Juli 2022 di Laboratorium Pendidikan Biologi, Universitas Timor. Penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan yaitu 0 (kontrol), 3%, 6%, dan 9% masing-masing dengan 5 ulangan. Nilai LC50 diperoleh dari analisis probit. Nilai letal konsentrasi (LC50) ekstrak daun sirsak dan ekstrak daun gamal berturut-turut sebesar 9.616% dan 6.724%. Nilai letal konsentrasi (LC50) kombinasi ekstrak daun sirsak dan daun gamal tidak ada yang dihitung karena rasio jumlah respon terhadap jumlah subjek adalah sama. Presentase mortalitas hama kumbang bubuk tertinggi terjadi ketika diberikan perlakuan konsentrasi 9 % ekstrak daun gamal dan konsentrasi 9 % ekstrak daun sirsak. Pemberian perlakuan konsentrasi 3 % kombinasi ekstrak daun sirsak dan daun gamal telah dapat mematikan seluruh hama uji. Kombinasi ekstrak daun gamal dan daun sirsak adalah ekstrak yang paling efektif membunuh hama kumbang. Namun jika dilihat dari nilai LC50 maka ekstrak yang paling efektif membunuh hama adalah ekstrak daun gamal diantara kedua ekstrak daun.
Sex-specific prevalence and risk factors of metabolic-associated fatty liver disease among 75,570 individuals in eastern China
Authors: Chang Mingxing , Shao Zhihao , Wei Wei , Shen Peipu , Shen Guifang 
Published: September 2023

BackgroundMetabolic-associated fatty liver disease (MAFLD) is a newly proposed definition and there is limited data on MAFLD prevalence. We aimed to investigate the prevalence of MAFLD in an eastern Chinese population.MethodsThis cross-sectional study included participants from an eastern Chinese population who underwent regular health checkups. Based on current diagnostic criteria, MAFLD was diagnosed in individuals with both hepatic steatosis and metabolic disorders. The overall and stratified prevalence derived based on sex, age, body mass index (BMI), and various metabolic disorders were estimated. Multivariate logistic regression analysis was used to determine the risk factors for MAFLD.ResultsAmong the 75,570 participants, the overall prevalence of MAFLD was 37.32%, with higher rates in men (45.66%) than in women (23.91%). MAFLD prevalence was highest in men aged 40–49 years (52.21%) and women aged 70–79 years (44.77%). In all the BMI subgroups, the prevalence was higher in men than in women. In both sexes, the prevalence of MAFLD increased as BMI levels increased. Furthermore, MAFLD was associated with metabolic disorders, especially in the female participants with severe obesity (odds ratio 58.318; 95% confidence interval: 46.978–72.397).ConclusionMAFLD is prevalent in the general adult population in eastern China. Sex-specific differences in MAFLD prevalence were identified based on age, BMI, and metabolic disorders. MAFLD is associated with metabolic disorders, particularly obesity.
Associations between greenspace characteristics and population emotion perceptions in three dimensions
Authors: Cao Zheng , Cao Ye , Wu Zhifeng 
Published: September 2023

Introduction: Mental disorders are considered to be the most significant threat to public health. Mitigation effects of urban green spaces have been widely documented. However, the conclusions are inconsistent because of the representativeness of the original data.Method: We measured the mental perception of urban green spaces using geospatial big data instead of field observation or questionnaire data. Street view data were applied to calculate urban green space characteristics in three dimensions.Results: The positive mental perception percentage around the chosen urban parks increased as the buffer diameter decreased. The temporal variations of positive mental perceptions around the selected urban parks exhibited an obvious peak-trough shape. The spatial associations between the positive mental perception percentage and urban green space characteristics varied geographically. The spatial associations became less similar as the spatial buffer diameter decreased. At the same spatial scale level, the green view played a dominant role in the spatial distribution of positive mental perceptions.Discussion: Shrinking the deviations of urban green space characteristics and increasing the mean and maximum values of urban green space characteristics will favor the improvement of public mental health. This study provides a reference for explaining ecological scientific questions using spatiotemporal big data. It also provides insights into the mechanisms underlying the relationship between ecological processes and public health.
Cost-effectiveness of neoadjuvant pembrolizumab plus chemotherapy with adjuvant pembrolizumab for early-stage non-small cell lung cancer in the United States
Authors: Tian Wentao , Niu Lishui , Wang Ziqi , Lu Ruoyu , Xiao Gang , Deng Fuxing , Tanzhu Guilong , Zhou Rongrong 
Published: September 2023

IntroductionPerioperative (neoadjuvant and adjuvant) pembrolizumab has shown favorable efficacy in patients with early-stage non-small cell lung cancer (NSCLC). This study aims to evaluate the cost-effectiveness of this treatment from the perspective of the United States healthcare payers.MethodsWe established a Markov model to compare the cost-effectiveness of perioperative pembrolizumab with that of neoadjuvant chemotherapy in 21-day cycles, utilizing data from the phase 3 KEYNOTE-671 trial. Additional data were extracted from other publications or online sources. Sensitivity analyses were conducted to evaluate the robustness of the findings. A willingness-to-pay threshold of $150,000 per quality-adjusted life-years (QALYs) gained was established. The main outcomes of this study were the measurement of QALYs, overall costs, incremental cost-effectiveness ratio (ICER), and net monetary benefit (NMB).ResultsDuring a 10-year time horizon, the total costs of perioperative pembrolizumab and the control treatment were $224,779.1 and $110,026.3, respectively. The QALYs were 4.19 and 2.97 for the two treatments, respectively, which led to an ICER of $94,222.29 per QALY gained. The NMB at the WTP threshold at $150,000 per QALY gained was $67,931.3. One-way sensitivity analysis identified the cost of pembrolizumab as the primary factor influencing cost-effectiveness. Probabilistic sensitivity analysis indicated a 97.7% probability of perioperative pembrolizumab being cost-effective at the WTP threshold.ConclusionsFrom the perspective of the United States healthcare payers, perioperative pembrolizumab is a cost-effective treatment for patients with early-stage NSCLC.
Genomic insight and physiological characterization of thermoacidophilic Alicyclobacillus isolated from Yellowstone National Park
Authors: Kim Hye Won , Kim Na Kyung , Phillips Alex P. R. , Parker David A. , Liu Ping , Whitaker Rachel J. , Rao Christopher V. , Mackie Roderick I. 
Published: September 2023

IntroductionAlicyclobacillus has been isolated from extreme environments such as hot springs, volcanoes, as well as pasteurized acidic beverages, because it can tolerate extreme temperatures and acidity. In our previous study, Alicyclobacillus was isolated during the enrichment of methane oxidizing bacteria from Yellowstone Hot Spring samples.MethodsPhysiological characterization and genomic exploration of two new Alicyclobacillus isolates, AL01A and AL05G, are the main focus of this study to identify their potential relationships with a thermoacidophilic methanotroph (Methylacidiphilum) isolated from the same hot spring sediments.Results and discussionIn the present study, both Alicyclobacillus isolates showed optimal growth at pH 3.5 and 55°C, and contain ω-alicyclic fatty acids as a major lipid (ca. 60%) in the bacterial membrane. Genomic analysis of these strains revealed specific genes and pathways that the methanotroph genome does not have in the intermediary carbon metabolism pathway such as serC (phosphoserine aminotransferase), comA (phosphosulfolactate synthase), and DAK (glycerone kinase). Both Alicyclobacillus strains were also found to contain transporter systems for extracellular sulfate (ABC transporter), suggesting that they could play an important role in sulfur metabolism in this extreme environment. Genomic analysis of vitamin metabolism revealed Alicyclobacillus and Methylacidiphilum are able to complement each other’s nutritional deficiencies, resulting in a mutually beneficial relationship, especially in vitamin B1(thiamin), B3 (niacin), and B7 (biotin) metabolism. These findings provide insights into the role of Alicyclobacillus isolates in geothermal environments and their unique metabolic adaptations to these environments.
Immature event-related alpha dynamics in children compared with the young adults during inhibition shown by day-night stroop task
Authors: Güntekin Bahar , Alptekin Simay , Yıldırım Ebru , Aktürk Tuba , Uzunlar Hakan , Çalışoğlu Pervin , Ada Figen Eroğlu , Atay Enver , Ceran Ömer 
Published: September 2023

IntroductionInhibitory control develops gradually from infancy to childhood and improves further during adolescence as the brain matures. Related previous studies showed the indispensable role of task-related alpha power during inhibition both in children and young adults. Nonetheless, none of the studies have been able to investigate the direct differences in brain responses between children and young adults when confronted with a stimulus that should be inhibited. Because, unlike event-related designs, task-related designs involve continuous tasks over a certain period, which precludes the possibility of making such a comparison. Accordingly, by employing event-related design, the present study first time in the literature, aimed to analyze the event-related alpha phase locking and event-related alpha synchronization/ desynchronization to differentiate the inhibitory processes in children compared to young adults.MethodsTwenty children between the ages of 6 to 7  years and 20 healthy young adult subjects between the ages of 18 to 30  years were included in the study. Day-night Stroop task was applied to all subjects during 18-channel EEG recordings. Event-related time-frequency analysis was performed with the complex Morlet Wavelet Transform for the alpha frequency band (8–13  Hz). Event related spectral perturbation (ERSP) in three different time windows (0–200  ms, 200–400  ms, 400–600  ms) and Event-related phase locking in the early time window (0–400  ms) was calculated.ResultsThe children had increased alpha power in early and late time windows but decreased alpha phase locking in the early time windows compared to young adults. There were also topological differences between groups; while young adults had increased alpha phase-locking in frontal and parietal electrode sites, children had increased occipital alpha power and phase locking.DiscussionThe shift in event-related alpha power observed from posterior to anterior regions with age may suggest a progressive maturation of the frontal areas involved in inhibitory processes from childhood to adulthood. The results of the present study showed that children and young adults had different EEG oscillatory dynamics during inhibitory processes at alpha frequency range.
Dose distribution prediction for head-and-neck cancer radiotherapy using a generative adversarial network: influence of input data
Authors: Gu Xiaojin , Strijbis Victor I. J. , Slotman Ben J. , Dahele Max R. , Verbakel Wilko F. A. R. 
Published: September 2023

PurposeA three-dimensional deep generative adversarial network (GAN) was used to predict dose distributions for locally advanced head and neck cancer radiotherapy. Given the labor- and time-intensive nature of manual planning target volume (PTV) and organ-at-risk (OAR) segmentation, we investigated whether dose distributions could be predicted without the need for fully segmented datasets.Materials and methodsGANs were trained/validated/tested using 320/30/35 previously segmented CT datasets and treatment plans. The following input combinations were used to train and test the models: CT-scan only (C); CT+PTVboost/elective (CP); CT+PTVs+OARs+body structure (CPOB); PTVs+OARs+body structure (POB); PTVs+body structure (PB). Mean absolute errors (MAEs) for the predicted dose distribution and mean doses to individual OARs (individual salivary glands, individual swallowing structures) were analyzed.ResultsFor the five models listed, MAEs were 7.3 Gy, 3.5 Gy, 3.4 Gy, 3.4 Gy, and 3.5 Gy, respectively, without significant differences among CP-CPOB, CP-POB, CP-PB, among CPOB-POB. Dose volume histograms showed that all four models that included PTV contours predicted dose distributions that had a high level of agreement with clinical treatment plans. The best model CPOB and the worst model PB (except model C) predicted mean dose to within ±3 Gy of the clinical dose, for 82.6%/88.6%/82.9% and 71.4%/67.1%/72.2% of all OARs, parotid glands (PG), and submandibular glands (SMG), respectively. The R2 values (0.17/0.96/0.97/0.95/0.95) of OAR mean doses for each model also indicated that except for model C, the predictions correlated highly with the clinical dose distributions. Interestingly model C could reasonably predict the dose in eight patients, but on average, it performed inadequately.ConclusionWe demonstrated the influence of the CT scan, and PTV and OAR contours on dose prediction. Model CP was not statistically different from model CPOB and represents the minimum data statistically required to adequately predict the clinical dose distribution in a group of patients.
Determination of genetic correlation between tobacco smoking and coronary artery disease
Authors: Zhu Zhouhai , Liu Qiang , Li Meng , Yao Yinghao , Qi Feiyan , Xu Yi , Lu Sheming , Yang Zhongli , Guan Ying , Li Ming D. , Yao Jianhua 
Published: September 2023

BackgroundsTobacco smoking is an important risk factor for coronary artery disease (CAD), but the genetic mechanisms linking smoking to CAD remain largely unknown.MethodsWe analyzed summary data from the genome-wide association study (GWAS) of the UK Biobank for CAD, plasma lipid concentrations (n = 184,305), and smoking (n = 337,030) using different biostatistical methods, which included LD score regression and Mendelian randomization (MR).ResultsWe identified SNPs shared by CAD and at least one smoking behavior, the genes where these SNPs are located were found to be significantly enriched in the processes related to lipoprotein metabolic, chylomicron-mediated lipid transport, lipid digestion, mobilization, and transport. The MR analysis revealed a positive correlation between smoking cessation and decreased risk for CAD when smoking cessation was considered as exposure (p = 0.001), and a negative correlation between the increased risk for CAD and smoking cessation when CAD was considered as exposure (p = 2.95E-08). This analysis further indicated that genetic liability for smoking cessation increased the risk of CAD.ConclusionThese findings inform the concomitant conditions of CAD and smoking and support the idea that genetic liabilities for smoking behaviors are strongly associated with the risk of CAD.
Spontaneous acute spinal subdural hematoma in patient on oral anticoagulant therapy
Authors: Kocić Svetlana , Aleksić Vuk , Stanić Milenko , Živković Aleksandra , Vojinović Radiša , Popović Igor 
Published: September 2023

Introduction: Spontaneous spinal subdural hematoma as a result of coagulation deficit is a very rare and serious condition, with an overall incidence of less than 1%. Symptoms can vary according to the level of the bleed. Prompt recognition of the presence of spinal subdural hematoma is crucial for treatment. MRI is the investigation of choice for diagnosis as well as for planning the surgery. The differential diagnosis includes abscess, lipomatosis, significant discal hernia and tumours. There are no definite guidelines for the management of spinal subdural hematomas. In cases with serious neurological deficits, prompt surgical evacuation may lead to the resolution of symptoms and complete neurological recovery.
Case report: We present a case of a 75-years-old man with bilateral lower limb radiculopathy, paresthesias, and spinal claudications for four days, progressing to bilateral paraplegia with urine incontinency. The patient was diagnosed with cauda equina syndrome due to spontaneous spinal subdural hematoma in the region from Th12 to L2. He was immediately operated and the subdural hematoma was evacuated. Minimal recovery was achieved and the patient was referred for further rehabilitation with severe paraparesis and urine incontinence.
Conclusion: Early diagnosis of spinal subdural hematoma is essential for treatment. Any delay of correct diagnosis can lead to a devastating neurological deficit. Spontaneous spinal subdural hematoma is one of the rare conditions where an emergency MRI is indicated and crucial for diagnosis.
Troponin and non-traumatic subarachnoid haemorrhage
Authors: Stoica Raluca , Iacob Diana-Gabriela , Iacob Gabriel 
Published: September 2023

Introduction: Subarachnoid haemorrhage (SAH) is a devastating event, with a mortality of up to 50%. Acute cardiac dysfunction is common after such an event, and it is known to have a negative impact on the outcome of these patients. Cardiac troponin release occurs frequently after SAH and represents an early biomarker for neurogenic cardiac dysfunction.
Objective: The present study aimed to evaluate the impact of a raised troponin value on the outcome of SAH patients.
Methods: This is a prospective observational study held between 2014-2017 at the University Emergency Hospital, Bucharest. Data on clinical admission status, high-sensitivity troponin I, ECG and echocardiographic evaluation results, ICU length of stay and in-hospital mortality rate. Statistical analysis was performed using non-parametrical Mann-Whitney and chi-square tests. The results were considered significant at p<0.05.
Results: A total of 335 consecutive patients with non-traumatic SAH were admitted during the study period. 92 of them were excluded and 243 were analyzed, 203 with aneurysmal SAH and 40 with non-aneurysmal, non-traumatic SAH. High-sensitivity troponin I reached its peak level 48 to 72 hours after SAH and was higher in patients with aneurysmal SAH. For all SAH patients, its median and peak values on days 1 and 2 were correlated with the ICU length of stay and inversely correlated with in-hospital length of stay. For the first 3 days, the median and maximum troponin values are higher in patients who died compared with those who survived and were discharged home (p-value < 0.001). Predictors of an elevated troponin on day 1 are loss of consciousness at ictus, a high Hunt and Hess and Fisher Scale grade, intraventricular haemorrhage and cerebral midline shift.
Conclusions: The release of cardiac troponin is a valuable marker of neurogenic cardiac dysfunction in the first 3 days after SAH. The study replicates other data in the literature and highlights the association between SAH severity, early troponin elevation and in-hospital death.