bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards Research Software-ready Libraries
Authors: Druskat Stephan , Bertuch Oliver , Struck Alexander 
Published: August 2023

Abstract
Software is increasingly acknowledged as valid research output. Academic libraries adapt to this change to become research software-ready. Software publication and citation are key areas in this endeavor. We present and discuss the current state of the practice of software publication and software citation, and discuss four areas of activity that libraries engage in: (1) technical infrastructure, (2) training and support, (3) software management and curation, (4) policies.
Klimawandel und Schädlinge in Bibliotheken und Archiven
Authors: Querner Pascal 
Published: August 2023

Zusammenfassung
Schädlingsprävention und -bekämpfung (IPM) ist ein Teil der präventiven Konservierung, und auch in Bibliotheken und Archiven ist der Schutz der Objekte und Materialien vor einem Befall und Schaden durch Insekten, Schimmel und Nager eine wichtige Maßnahme, um die Sammlung für zukünftige Generationen zu erhalten. In diesem Beitrag wird auf die wichtigsten Bestandteile des IPM-Konzeptes eingegangen, dazu gehören ein Monitoring, Quarantäne, eine gute Reinigung, Abdichtung des Gebäudes, eine Schulung der Mitarbeitenden, möglichst giftfreie Bekämpfungsmethoden und ein möglichst kühles Innenklima. Letzteres wird durch den Klimawandel schon jetzt beeinflusst, und in der Zukunft können höhere Temperaturen, Starkregenereignisse und neue eingeschleppte Schädlinge neue Herausforderungen für Bibliotheken und Archive sein. Besonders historische Bibliotheken, ohne ein reguliertes Innenklima, stehen vor großen Herausforderungen, und neue Arten wie das Papierfischchen haben in den letzten Jahren schon zu vielen Problemen geführt. Neue Methoden in der Bekämpfung, aber auch Detektion werden vorgestellt.
Tanshinone IIA alleviates chondrocyte apoptosis and extracellular matrix degeneration by inhibiting ferroptosis
Authors: Xu Jin , Zhi Xiaocheng , Zhang Yunhui , Ding Ren 
Published: August 2023

Abstract
Articular cartilage degeneration caused by chondrocyte damage is the primary pathological mechanism of osteoarthritis (OA). Oxidative stress is correlated with chondrocyte injury by potentiating ferroptosis, a newly identified form of cell death. Given the effects of Tanshinone IIA (Tan IIA) on alleviating oxidative stress, we further explored whether Tan IIA inhibited chondrocyte death and cartilage degeneration by decreasing ferroptosis. ATDC5 chondrocytes were treated with lipopolysaccharides (LPS) and Tan IIA, and cell viability was assessed using cell counting kit-8 (CCK-8) assays. Matrix metalloproteinase-13 (MMP13), a disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS5), and type II collagen (Col II) levels were measured using quantitative real-time polymerase chain reaction (qRT‒PCR), western blotting, and immunofluorescence (IF) analysis. We demonstrated that Tan IIA treatment prominently increased ATDC5 cell viability and decreased cell apoptosis in the presence of LPS-induced stress. MMP13 and ADAMTS5 expression was increased, and Col II expression was decreased in ATDC5 cells after LPS stimulation, whereas these changes were reversed by Tan IIA. Mechanistically, Tan IIA inhibited LPS-induced ferroptosis in ATDC5 cells, as indicated by decreased levels of iron, reactive oxygen species, and malondialdehyde and increased GSH levels. Importantly, a ferroptosis agonist partially abrogated the effect of Tan IIA on alleviating chondrocyte damage and death. Taken together, these results suggest that Tan IIA ameliorates chondrocyte apoptosis and cartilage degeneration by inhibiting ferroptosis and may be a potential therapeutic agent for OA.
The Impact of Initial Intellectual Property Decisions of Start-Ups on Innovation Performance
Authors: Li Hong , Gan Mengge , Zhang Yibin 
Published: August 2023

Abstract
We analyze the initial intellectual property (IP) decisions of 336 start-ups in IP-intensive industries in China, distinguishing among patents, trademarks, and IP portfolios. Our empirical results show that the initial IP decisions of start-ups have an impact on their innovation performance. Compared with start-ups that choose trademarks or patents, start-ups that choose IP portfolios have higher financial and non-financial innovation performance. Furthermore, venture capital positively moderates the relationship between initial IP decisions and non-financial innovation performance. VC-backed start-ups that choose IP portfolios are more likely than other start-ups to achieve higher non-financial innovation performance. Finally, strategic planning also plays a role in the relationship. Among the start-ups that choose IP portfolios, those with high strategic planning gain higher non-financial innovation performance. This paper contributes to research on initial IP decisions in entrepreneurial contexts by incorporating IP portfolios to initial IP decisions and uncovering the role of initial IP decisions in innovation performance.
Entropy minimization of GO–Ag/KO cross-hybrid nanofluid over a convectively heated surface
Authors: Lone Showkat Ahmad , Al-Essa Laila A. , Al-Bossly Afrah , Alduais Fuad S. , Ali Farhan , Eldin Sayed M. , Saeed Anwar 
Published: August 2023

Abstract
The aim of this study is to provide numerical solutions to magnetohydrodynamic (MHD) cross flow with heat and mass transfer over a stretching sheet in a hybrid nanofluid with suction/injection and convective boundary conditions. This will be accomplished by presenting numeric solutions. Nanoparticles of graphene oxide and silver were suspended in kerosene oil as the base fluid taken into consideration is a nanofluid hybrid. After that, the physical flow problem is modeled as a set of partial differential equations, which are then transformed into an equivalent system of nonlinear ordinary differential equations (ODEs) by making use of the relevant similarity transformations. To gain different graphical and numerical results for analyzing the influence of numerous physical restrictions on velocity, heat, and mass profiles, the system of ODEs is solved using the computing power of the Lobatto IIIA technique. The plot of the velocity profile, temperature, concentration, entropy generation and Bejan number with separating magnitude like that power index number (

0.1
<
n
<
2.0

0.1\lt n\lt 2.0

), Weissenberg number (

0.1
<
We
<
1.0

0.1\lt {\rm{We}}\lt 1.0

), Suction/injection (

0.1
<
S
<
1.0

0.1\lt S\lt 1.0

), Magnetic parameter (0.1 < M < 1.0), Biot number (

0.1
<
Bi
<
0.3

0.1\lt {\rm{Bi}}\lt 0.3

), Radiation parameter (

0.1
<
Rd
<
2.0

0.1\lt {\rm{Rd}}\lt 2.0

), Schmidt number (

1.1
<
Sc
<
2.0

1.1\lt {\rm{Sc}}\lt 2.0

), and Chemical reaction parameter (

1.1
<
Sc
<
2.0

1.1\lt {\rm{Sc}}\lt 2.0

). We noted that when the Weissenberg parameter (

We

{\rm{We}}

) increases, the flow speed will increase as well. Also, the increasing values of

M

M

slows the flow speed but the opposite effect is observed in the temperature profile. Moreover, the greater values of

M

M

, We, and S reduced in the local skin friction. It is concluded that hybrid nanofluid is better than ordinary nanofluid by percentage values. The results are used in industry and technology in fluid-based systems with shrinkable or flexible materials, MHD flow meters, pumps, and the drawing of plastic strips. Because hybrid nanoparticles speed up the cooling process, they are important in cutting and production.
Investigations on terthiophene as an electrically conductive polymer for UV laser lithography
Authors: Ziemer Thorben , Ziegmann Gerhard , Rembe Christian 
Published: August 2023

Abstract
Polymers hold great potential for the use in microsensors and organic electronics. They are highly adaptable, easy to process and can contribute new or improved capabilities compared to semiconductors. Direct UV laser lithography also gains increasing attention. Because it avoids expensive photomasks, it is especially attractive where small numbers of specialized microcomponents are needed, like in prototyping. Lithography necessitates materials, which can be shaped by UV radiation. For many microsensor applications, there is the additional requirement of electric conductivity, preferably in the same material. We approached this demand by combining a Novolak and terthiophene doped with copper(II) perchlorate to form an interpenetrating polymer network, which possesses properties of both of its constituents. From this, we manufactured test structures with the UV laser of a micro pattern generator. In previous conference contributions, we showed a first proof of principle. In this publication, we present results of new experiments that demonstrate the characteristics in more detail. We improved our electrical setup to conduct four-terminal measuring. We used it to first verify previous results and investigated the material’s response to alternating currents up to 10 kHz. We then compared the electrical resistivity of differently sized structures for temperatures between 20 and 90 °C and examined long-term stability of their resistance by subjecting samples to temperatures of up to 60 °C for several hours. Additionally, we tested the influence of UV radiation on the resistance. Our samples exhibited good lithographic qualities. Resistivities were around 2 Ω mm and temperature sensitivity up to −407 Ω K−1. UV radiation induced a partially reversible increase of the electric resistance. The long-term stability of the material was temperature-dependent.
KIERKEGAARD E AS CIÊNCIAS NATURAIS NO SÉCULO XIX
Authors: Teixeira Natalia Mendes 
Published: August 2023

O filósofo dinamarquês Søren A. Kierkegaard é frequentemente lido, dentro da própria tradição intérprete, como um crítico das Ciências Naturais (Naturvidenskaben). 1 Neste artigo, pretendo argumentar, ao contrário, que Kierkegaard: (i) foi crítico de uma determinada prática científica do seu tempo epistemicamente frágil e dos cientistas naturais que a adotavam construindo uma proposta judiciosa do papel da Ciência na interpretação do mundo; (ii) interessou-se pelas Ciências Naturais, inclusive pelos trabalhos do seu primo, o paleontólogo Peter Wilhelm Lund, e as pesquisas de Hans Christian Ørsted, um expressivo cientista dinamarquês contemporâneo; (iii) ao criticar os pressupostos metodológicos de Carl Gustav Carus, o primeiro psicólogo a fazer referência à existência do inconsciente, Kierkegaard toma partido no vitalismus-materialismusstreit; (v) Por fim, e talvez mais importante, Kierkegaard propôs limites éticos e epistêmicos à Ciência e inspirou os pressupostos da filosofia da ciência de filósofos contemporâneos como Paul Feyerabend.
Divergent Actions of Renal Tubular and Endothelial Type 1 IL-1 Receptor Signaling in Toxin-Induced AKI
Authors: Ren Jiafa , Liu Kang , Wu Buyun , Lu Xiaohan , Sun Lianqin , Privratsky Jamie R. , Xing Changying , Robson Matthew J. , Mao Huijuan , Blakely Randy D. , Abe Koki , Souma Tomokazu , Crowley Steven D. 
Published: August 2023

Significance Statement
Activation of the type 1 IL-1 receptor (IL-1R1) triggers a critical innate immune signaling cascade that contributes to the pathogenesis of AKI. However, blockade of IL-1 signaling in AKI has not consistently demonstrated kidney protection. The current murine experiments show that IL-1R1 activation in the proximal tubule exacerbates toxin-induced AKI and cell death through local suppression of apolipoprotein M. By contrast, IL-1R1 activation in endothelial cells ameliorates AKI by restoring VEGFA-dependent endothelial cell viability. Using this information, future delivery strategies can maximize the protective effects of blocking IL-1R1 while mitigating unwanted actions of IL-1R1 manipulation.

Background
Activation of the type 1 IL-1 receptor (IL-1R1) triggers a critical innate immune signaling cascade that contributes to the pathogenesis of AKI. IL-1R1 is expressed on some myeloid cell populations and on multiple kidney cell lineages, including tubular and endothelial cells. Pharmacological inhibition of the IL-1R1 does not consistently protect the kidney from injury, suggesting there may be complex, cell-specific effects of IL-1R1 stimulation in AKI.

Methods
To examine expression of IL-1 and IL-1R1 in intrinsic renal versus infiltrating immune cell populations during AKI, we analyzed single-cell RNA sequencing (scRNA-seq) data from kidney tissues of humans with AKI and mice with acute aristolochic acid exposure. We then investigated cell-specific contributions of renal IL-1R1 signaling to AKI using scRNA-seq, RNA microarray, and pharmacological interventions in mice with IL-1R1 deletion restricted to the proximal tubule or endothelium.

Results
scRNA-seq analyses demonstrated robust IL-1 expression in myeloid cell populations and low-level IL-1R1 expression in kidney parenchymal cells during toxin-induced AKI. Our genetic studies showed that IL-1R1 activation in the proximal tubule exacerbated toxin-induced AKI and cell death through local suppression of apolipoprotein M. By contrast, IL-1R1 activation in endothelial cells ameliorated aristolochic acid–induced AKI by restoring VEGFA-dependent endothelial cell viability and density.

Conclusions
These data highlight opposing cell-specific effects of IL-1 receptor signaling on AKI after toxin exposure. Disrupting pathways activated by IL-1R1 in the tubule, while preserving those triggered by IL-1R1 activation on endothelial cells, may afford renoprotection exceeding that of global IL-1R1 inhibition while mitigating unwanted actions of IL-1R1 blockade.
Renin–Angiotensin–Aldosterone System Blockade after AKI with or without Recovery among US Veterans with Diabetic Kidney Disease
Authors: Murphy Daniel P. , Wolfson Julian , Reule Scott , Johansen Kirsten L. , Ishani Areef , Drawz Paul E. 
Published: August 2023

Significance Statement
Among patients with CKD, optimal use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers after AKI is uncertain. Despite these medications' ability to reduce risk of mortality and other adverse outcomes, there is concern that ACEi/ARB use may delay recovery of kidney function or precipitate recurrent AKI. Prior studies have provided conflicting data regarding the optimal timing of these medications after AKI and have not addressed the role of kidney recovery in determining appropriate timing. This study in US Veterans with diabetes mellitus and proteinuria demonstrated an association between ACEi/ARB use and lower mortality. This association was more pronounced with earlier post-AKI ACEi/ARB use and was not meaningfully affected by initiating ACEis/ARBs before versus after recovery from AKI.

Background
Optimal use of angiotensin-converting enzyme inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) after AKI is uncertain.

Methods
Using data derived from electronic medical records, we sought to estimate the association between ACEi/ARB use after AKI and mortality in US military Veterans with indications for such treatment (diabetes and proteinuria) while accounting for AKI recovery. We used ACEi/ARB treatment after hospitalization with AKI (defined as serum creatinine ≥50% above baseline concentration) as a time-varying exposure in Cox models. The outcome was all-cause mortality. Recovery was defined as return to ≤110% of baseline creatinine. A secondary analysis focused on ACEi/ARB use relative to AKI recovery (before versus after).

Results
Among 54,735 Veterans with AKI, 31,146 deaths occurred over a median follow-up period of 2.3 years. Approximately 57% received an ACEi/ARB <3 months after hospitalization. In multivariate analysis with time-varying recovery, post-AKI ACEi/ARB use was associated with lower risk of mortality (adjusted hazard ratio [aHR], 0.74; 95% confidence interval [CI], 0.72 to 0.77). The association between ACEi/ARB use and mortality varied over time, with lower mortality risk associated with earlier initiation (P for interaction with time <0.001). In secondary analysis, compared with those with neither recovery nor ACEi/ARB use, risk of mortality was lower in those with recovery without ACEi/ARB use (aHR, 0.90; 95% CI, 0.87 to 0.94), those without recovery with ACEi/ARB use (aHR, 0.69; 95% CI, 0.66 to 0.72), and those with ACEi/ARB use after recovery (aHR, 0.70; 95% CI, 0.67 to 0.73).

Conclusions
This study demonstrated lower mortality associated with ACEi/ARB use in Veterans with diabetes, proteinuria, and AKI, regardless of recovery. Results favored earlier ACEi/ARB initiation.
Tracking emergency response actions during COVID-19 leads to development of an innovative public health evaluation tool
Authors: Biro Suzanne , Scott Karen , Nagy Emma , Slipp Nancy , Beck Kinsey , Catley Christina , Hart Ezra 
Published: August 2023

Abstract
Setting
Early in the pandemic, KFL&A Public Health needed a way to capture, organize, and display COVID-19-related events to be accountable for and evaluate our actions.

Intervention
We used accessible software (Microsoft Office 365 suite, Microsoft PowerBI) to develop a data collection and visualization system. The Canadian Institute for Health Information (CIHI) developed a timeline and categorization approach for provincial and national COVID-related interventions, which was used to develop a regional version for local events using similar categories. We collected and displayed qualitative data alongside epidemiological data that allowed users to display different timelines of actions and outcomes and evaluate our response.

Outcomes
In developing the timeline, we took stock of the information and data we wanted to collect, sort, and display locally. Next, we collected information on response actions, case and contact tracing, and staffing changes in a database that we displayed on a timeline. We included CIHI’s data set to provide insight into pandemic response across all jurisdictions.

Implications
Our timeline tool has many advantages for public health authorities beyond responding to a rapidly evolving emergency. By collecting information on events as they occur, decisions and actions are documented that may otherwise be overlooked. This enables decision-makers to visualize the impact of public health actions on health outcomes over time. The tool is completely customizable and scalable depending on the project scope and we plan to apply this method to other public health programming. Finally, we include lessons learned from quickly developing these tools in a real-time pandemic setting, both locally at KFL&A Public Health and nationally at CIHI.
Dynamics of the incidence of benign breast disease at the regional level
Authors: Sevostyanova O. Yu. , Chumarnaya T. V. , Sevostyanova N. E. , Demidov D. A. , Vorontsova A. V. , Oboskalova T. A. 
Published: August 2023

Background. The analysis of the incidence of benign breast disease (BBD) allows you to control the prevalence of the disease in the population and plan medical care.Aim. To study the incidence and prevalence of BBD on the example of the Sverdlovsk region in 2012–2021 and Yekaterinburg in 2012–2020.Materials and methods. An observational epidemiological retrospective study of the incidence of BBD in women aged 18 years and more was conducted. To calculate the indicators, we used the form of Federal statistical observation No. 12 for Yekaterinburg and recommendations by the Federal State Statistics Service, Russian Research Institute of Health. We analyzed the indicators of the incidence of BBD in the Sverdlovsk region, published on the websites of the Ministry of Health of Russia and the Russian Research Institute of Health. Information on the number of women examined for oncopathology was obtained from Form No. 30 “Information about a medical organization” in 2016–2020.Results. The incidence of BBD in the Sverdlovsk region increased in 2013–2019 and Yekaterinburg 2015–2019 compared to 2012 (p <0.001). During the pre-pandemic period, the average growth rate of the indicator was 5.20 % in the region, 7.60 % in the city. The incidence of BBD in the city annually exceeded the regional indicator in 2012–2019 (p <0.028). The prevalence of BBD followed the trends of the incidence (p <0.001). The average growth rate of the total incidence in the region was 7.55 %, in the city – 9.57 %. A decrease in incidence rates in the region and the city in 2020 compared to 2019 was incidence (p <0.001). A positive correlation was established between the number of cases of newly diagnosed ВВD and the number of women examined for oncopathology in the region (r = 0.924 at p = 0.025) and the city (r = 0.900 at p = 0.037).Conclusion. The incidence and prevalence of BBD in the female population of the region and the city significantly increased in the pre-pandemic period. There was a decrease in indicators due to the massive and rapid spread of a new coronavirus infection and restrictive measures aimed at containing it in 2020–2021.
Tracking the Effect of Human Activity on MeSO-net Noise Using Seismic Data Traffic—Did Seismic Noise in Tokyo Truly Decrease during the COVID-19 State of Emergency?
Authors: Hayashida Takumi , Yoshimi Masayuki , Suzuki Haruhiko , Mori Shinichiro , Kagawa Takao , Ichii Koji , Yamada Masayuki 
Published: August 2023

Abstract
Human activities cause seismic noise over 1 Hz (cultural noise), and the recent articles have reported that the curtailing of socioeconomic activities during the novel coronavirus (COVID-19) pandemic in 2020 appeared to reduce high-frequency seismic noise amplitudes in cities. The Tokyo metropolitan area in Japan, where seismic stations are densely distributed and various anthropogenic activities have been closely monitored, is an ideal study area to investigate the effect of human activity on high-frequency seismic noise during the pandemic. We demonstrated that the magnitude of seismic data traffic (SDT), indexed by the packet size of continuous seismic data in WIN32 format, is a good indicator for monitoring time-dependent changes in high-frequency noise levels. The SDT of 169 Metropolitan Seismic Observation network (MeSO-net) stations—a continuous accelerometer network that is mostly located at schools in the Tokyo metropolitan area—decreased by approximately 1%–3% from March to June 2020, when a state of emergency in Japan was first declared, compared with that in the previous year. We revealed that the SDT decrease was prominent only at stations near school buildings, and the SDT trend was uncorrelated with the temporal changes in the population and vehicular traffic volume near the seismic stations. We also found strong correlations between the SDT reduction and school size (classified by the number of students enrolled), implying that the noise decrease at the MeSO-net stations during the pandemic was strongly influenced by school-based activities. Thus, the noise reduction observed at MeSO-net stations during the COVID-19 pandemic in 2020 did not provide strong evidence of quieting in the Tokyo metropolitan area.