bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phraseme im Songkorpus: Etabliertes in Anti-Establishment-Texten
Authors: Donalies Elke 
Published: May 2023

Das Songkorpus erlaubt Einblicke in bestimmte gesellschaftliche Diskurse, die in anderen Sprachkorpora weniger zur Geltung kommen. Das zeigt sich auch bei der Analyse von Phrasemen im Songkorpus.
Phraseme sind etablierte Wortkombinationen; sie konservieren kollektives Wissen, kollektive Kultur. Element of Crime, Fettes Brot, Udo Lindenberg, Stefan Stoppok, Konstantin Wecker, Marius Müller-Westernhagen, die Autoren meines kleinen Teilkorpus, sind Anti-Establishment und alles andere als konservativ. Zwar verwenden sie häufig Phraseme verschiedenster Struktur und Art, karikieren sie aber auch häufig, spielen lässig mit ihnen, hinterfragen ihre Bedeutung, verändern ihre Bedeutung. Ihre spezielle Haltung bedingt spezielle Phraseme und spezielle Phrasemvarianten.
Dietary supplement using cockroach meal: impact on growth indices and biochemical responses in hybrid catfish
Authors: Kolawole Abiola Olabisi , Adamu Kabir Mohammed , Usman Ibrahim Baba , Mohammed Yakubu Manbe , Aliyu-Paiko Mohammed 
Published: May 2023

Globally the need to substitute fishmeal with other animal protein sources in the fish diet has gained more attention; which is occasioned by the increasing cost of fish. A 12-week trial was conducted to ascertain the growth indices and biochemical response of hybrid catfish (Clarias gariepinus(♀) and Heterobranchus bidorsalis (♂)) fed cockroach meal supplement. A total of 800 hybrid catfish were randomly distributed into four dietary treatments (Diet A- control feed), Diet B (50 % cockroach and 50 % fishmeal), Diet C (100 % cockroach meal) and Diet D (100 % fishmeal). Each treatment was replicated with 35 fish per experimental pond in a completely randomized design. Progressive weight gain was determined bi-weekly. At the end of the study period, fishes were randomly sacrificed for proximate compositions and plasma biochemical analyses (glucose, triglyceride, cholesterol, total protein, albumin) using standard protocols. The study revealed that growth parameters (Weight gain, Average weight gain, Protein efficiency ratio, Feed Conversion rate, Specific growth rate and Survival rate (SR) were influenced by the dietary treatments (p>0.05). The highest weight gain was recorded in Diet 1 (8847.73±292.65 g) > Diet 2 (7816.33±121.71 g)>Diet 3 (7811.67±566.08 g) >Diet 4 (7022.00±44.193 g). Similarly, the best feed conversion ratio was found in fish fed Diet A (10.12±0.01),>Diet B, C and D had the same values of 0.11 g respectively. There was no significant (p>0.05) difference in plasma biochemical indicators measured when compared to the control (Diet A). Thus, indicating that all the fish were healthy and had normal physiological activities. Cockroach meal can therefore, be used as a feed supplement without having any adverse effect on the growth and well-being of hybrid catfish fingerlings
Nutraceuticals a Food for Thought in the Treatment of Parkinson’s
Disease
Authors: Bansal Keshav , Singh Sakshi , Singh Vanshita , Bajpai Meenakshi 
Published: May 2023

Background:
Brain disorders are presently one of the most serious and challenging
health issues in the world. A significant portion of morbidities and fatalities worldwide are caused
by these brain disorders. Parkinson's disease (PD) is a neurological condition that develops when
dopaminergic neurons are lost in the substantia nigra, causing cognitive and motor impairment.

Objectives:
Conventional treatment modalities, including dopamine replacement therapy and
optimization of dopaminergic transmission approaches, don’t address the pathogenic processes
primary to the symptoms of PD and usually become the least essential with time. Researchers are
aiming to provide effective treatment in treating PD with minimizing adverse consequences. In
the past few years, a number of studies on nutraceuticals have been conducted to produce foods
with fewer adverse effects and increased therapeutic effectiveness. The use of these nutraceuticals
is typically risk-free and can be coupled with the patient's current common pharmacological therapy
to enhance the standard of living and lessen PD symptoms.

Conclusion:
The current review focuses on a number of important nutritional compounds and dietary
changes that have been shown to be effective against a number of the pathogenic pathways
involved in the onset and progression of Parkinson's disease (PD), and further lights the justification
for their prospect use in the treatment and prevention of PD.
Rethinking Tako-tsubo Cardiomyopathy: The Contribution of Myocardial
Pathology and Molecular Imaging
Authors: Sestini Stelvio , Coppola Angela , Dona Manjola , Martini Anna Lisa , Tardelli Elisa , Montelatici Giulia , Laghai Iashar , Arena Angela , Carli Giulia , Pestelli Francesco , Maraviglia Bianca , Bruni Giulia , Mazzeo Christian , Fedeli Luca , Mansi Luigi 
Published: May 2023

Background:
Despite substantial research, the mechanisms behind stress Tako-tsubo
cardiomyopathy (TTC) remain rather elusive.

Objective:
The purpose of this paper was to provide a detailed review of the mainstream factors
underlying the pathophysiology of TTC, highlighting the novel contributions of molecular pathology
and in-vivo molecular imaging.

Methods:
A careful literature review selected all papers discussing TTC, specifically those providing
novel insights from myocardial pathology and cardiac molecular imaging.

Results:
Results concerning myocardial pathology, defect extension, sites and relationships
between functional parameters underline the existence of a causal relationship between a determinant
(e.g., the release of catecholamines induced by stress) and an outcome for TTC, which is not
limited to a reversible contractile cardiomyopathy, but it includes reversible changes in myocardial
perfusion and a long-lasting residual deficit in sympathetic function. Besides, they reinforce the
hypothesis that sympathetic nerves may exert a complex control on cardiac contractile function,
which is likely to be direct or indirect through metabolism and microvascular perfusion changes
during anaerobic and aerobic conditions.

Conclusion:
TTC is characterized by acute transient left ventricular systolic dysfunction, which
can be challenging to distinguish from myocardial infarction at presentation. Catecholamineinduced
myocardial injury is the most established theory, but other factors, including myocardial
metabolism and perfusion, should be considered of utmost importance. Each effort to clarify the
numerous pathways and emerging abnormalities may provide novel approaches to treat the acute
episode, avoid recurrences, and prevent major adverse cardiovascular events.
Design, Synthesis and Antimicrobial Activity of 1,3-Diazine Derivatives
Authors: Jadhav Pranali A. , Jagtap Jayashree R. , Deodhar Meenakshi N. , Chavan Rajashri S. , Pawar Smita J. 
Published: May 2023

Background:
Pyrimidines have been shown to possess numerous biological activities, such as antimicrobial, anticancer, anticonvulsant, antiviral, and anti-inflammatory.

Objective:
Encouraged by these data, the synthesis of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4- amino-6-phenylpyrimidine-5-carbonitrile (3a-g) was performed.

Methods:
4-amino-2-mercapto-6-phenylpyrimidine-5-carbonitrile was dissolved in an aqueous sodium hydroxide solution, and to this clear solution, 2-chloromethyl-1H-benzimidazole in methanol was added, and the reaction mixture was stirred under reflux to get the desired product. The structures of the newly synthesized compounds were confirmed by their physical, chemical, and spectral data. The synthesized derivatives were screened for their in vitro antibacterial activity against Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, and Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa, by using ciprofloxacin as a reference standard. While, their antifungal activity was evaluated against Aspergillus niger and Candida albicans using fluconazole as a reference drug. The docking study was performed to check the interactions of target compounds (3a-g) with homo sapiens DHFR (PDB: 1S3V), bacterial (S. aureus) DHFR (PDB: 2W9T), and DHPS (PDB: 1AD4) protein. The dock score and binding interactions were recorded.

Results:
The antimicrobial activity study indicated compounds with chloro (3b), fluoro (3f), and bromo (3g) substituents to show good antibacterial as well as antifungal activity. The docking study revealed that the same compounds, i.e., 3b, 3f, and 3g, showed good dock score and comparable interactions compared to the reference ligand (trimethoprim/sulfadiazine), which confirmed their selectivity.

Conclusion:
It can be presumed that the synthesized compounds have the capability for further promotion as novel antimicrobial agents.
Investigation of Developmental Toxicity Profile of Edible Lablab (Lablab
purpureus (l.) Sweet Purpurea) bean Extract using Brine Shrimp and Zebrafish
Authors: Ghosh Rakesh , Pramanick Arghya , Sarkar Nilanjan , Mukherjee Swarupananda , Kumari Amrita , Roy Kalyan , Karunakaran Gauthaman , Mal Mainak , Chakraborty Mainak 
Published: May 2023

Background:
Developmental toxicology deals with the effects of compounds on fertility and with birth defects that could occur at any stage of the reproductive cycle. In this study, we evaluated the teratogenic effects of Lablab purpureus (L.) Sweet beans on zebrafish embryo.

Objectives:
The developmental toxicity study was carried out to evaluate the toxicity induced by Lablab purpureus (L.) Sweet on zebrafish embryo. We also studied the cytotoxicity of Lablab purpureus (L.) Sweet beans.

Methods:
Zebrafish embryos were exposed to a methanolic extract of Lablab purpureus (L.) Sweet beans at concentrations of 10,25,50, and 100 μg/ml starting from 24 hours post fertilization (HPF) to 72 HPF. Developmental defects, if any, were observed under a microscope. Cytotoxicity of Lablab purpureus (L.) Sweet beans were also evaluated by using brine shrimp and the corresponding LC50 value of the methanolic extract of Lablab purpureus (L.) Sweet beans were also calculated.

Results:
The LC50 value of the methanolic extract of Lablab purpureus (L.) Sweet beans were found to be 77 μg/ml. However, some forms of developmental toxicity were observed in zebrafish embryos when treated with different concentrations of Lablab purpureus (L.) Sweet beans extract.

Conclusion:
The methanolic extract of Lablab purpureus (L.) Sweet beans were found to be cytotoxic in brine shrimp, and the LC50 value was found to be 77 μg/ml. However, there was some level of developmental toxicity in the Zebrafish embryo model at different concentrations of Lablab purpureus (L.) Sweet beans extract.
Curcumin-conjugated Nanoparticles: An Approach to Target Mitochondria
Authors: Suvarna Vasanti , Sawant Niserga , Desai Namita 
Published: May 2023

Background:
Unconjugated nanoparticles used in the treatment of cancer and various metabolic
and neurodegenerative disorders exhibit extended blood circulation time, inhibition of enzymatic degradation,
and increased chemical stability of the encapsulated therapeutic molecules. However, the unconjugated
nanoparticles often show off-target effects and lack of specificity, which limit their applications in
the healthcare system.

Objective:
Curcumin, a polyphenolic compound known for its proficiency to scavenge reactive oxygen
species attributed to antioxidant activity and anticancer effects associated with mitochondrial dysfunction,
is one of the most effective therapeutic agents. Therefore, with respect to chemotherapeutic strategies, the
development of mitochondrial targeting curcumin nanoparticles for target-specific drug delivery has been
extensively studied.

Conclusion:
The present review has focused on diverse curcumin-loaded nanoparticles targeting mitochondria
along with their improved delivery potential, enhanced localization and biodistribution profile.
Structural Insights to the Pathophysiology of Effector Induced Immunostimulation
in Salmonella Typhimurium: Biocomputational Methods
Authors: Choudhury Abhigyan 
Published: May 2023

Introduction:
The worldwide impact of the foodborne pathogen Salmonella can never
be overstated, nor can be the fatal threat of septicemia in patients infected with its Typhimurium
serovar. Behind the hyperimmune response in the case of septicemia lies a critical phenomenon of
the bacterial pathogenic signals being sensed by different pattern recognition receptors, such as the
Typhimurium effector proteins that are detected by toll-like receptors.

Methods:
To mitigate such a threat, precise structural and functional description of these effectors
is necessary. The same has been addressed in this article using accelerated biocomputational techniques,
beginning with the identification of the functional niche of the effectors and their influence
over other proteins.

Results:
The molecular crystal structures were retrieved, and rigorous molecular docking experiments were conducted among the TLRs and effector proteins in order to examine the interactions. The interactions were thereby evaluated and screened according to their respective strengths using parameters including binding affinity, dissociation constant, hydropathy variation, etc. SopB effectors were found to be detected by three different TLR proteins and GtgE by two other TLRs, while SifA, SrfJ, and SsaV had only a single interacting TLR partner each. Interestingly, TLR9 presented lower sensitivity towards PAMPs of this bacterium.

Conclusion:
Normal modal analyses in combination with atomistic molecular dynamics simulations that tend to imitate natural cytosolic environments reveal stable and consistent interactions and realistic conformations among the effector-bound TLR complexes. The findings open up new avenues for the development of targeted therapies against Salmonella, which could significantly reduce the global burden of this foodborne pathogen.
Blended Care in Patients With Knee and Hip Osteoarthritis in Physical Therapy: Delphi Study on Needs and Preconditions
Authors: Weber Franziska , Kloek Corelien , Arntz Angela , Grüneberg Christian , Veenhof Cindy 
Published: May 2023

Background
Osteoarthritis is a major public health concern. Despite existing evidence-based treatment options, the health care situation remains unsatisfactory. Digital care options, especially when combined with in-person sessions, seem to be promising.

Objective
The aim of this study was to investigate the needs, preconditions, barriers, and facilitators of blended physical therapy for osteoarthritis.

Methods
This Delphi study consisted of interviews, an online questionnaire, and focus groups. Participants were physical therapists, patients with hip and/or knee osteoarthritis with or without experience in digital care, and stakeholders of the health care system. In the first phase, interviews were conducted with patients and physical therapists. The interview guide was based on the Consolidated Framework For Implementation Research. The interviews focused on experiences with digital and blended care. Furthermore, needs, facilitators, and barriers were discussed. In the second phase, an online questionnaire and focus groups served the process to confirm the needs and collect preconditions. The online questionnaire contained statements drawn by the results of the interviews. Patients and physical therapists were invited to complete the questionnaire and participate in one of the three focus groups including (1) patients; (2) physical therapists; and (3) a patient, a physical therapist, and stakeholders from the health care system. The focus groups were used to determine concordance with the results of the interviews and the online questionnaire.

Results
Nine physical therapists, seven patients, and six stakeholders confirmed that an increase of acceptance of the digital care part by physical therapists and patients is crucial. One of the most frequently mentioned facilitators was conducting regular in-person sessions. Physical therapists and patients concluded that blended physical therapy must be tailored to the patients’ needs. Participants of the last focus group stated that the reimbursement of blended physical therapy needs to be clarified.

Conclusions
Most importantly, it is necessary to strengthen the acceptance of patients and physical therapists toward digital care. Overall, for development and usage purposes, it is crucial to take the needs and preconditions into account.

Trial Registration
German Clinical Trials Register DRKS00023386; https://drks.de/search/en/trial/DRKS00023386
Data Analysis of Physician Competence Research Trend: Social Network Analysis and Topic Modeling Approach
Authors: Yune So Jung , Kim Youngjon , Lee Jea Woog 
Published: May 2023

Background
Studies on competency in medical education often explore the acquisition, performance, and evaluation of particular skills, knowledge, or behaviors that constitute physician competency. As physician competency reflects social demands according to changes in the medical environment, analyzing the research trends of physician competency by period is necessary to derive major research topics for future studies. Therefore, a more macroscopic method is required to analyze the core competencies of physicians in this era.

Objective
This study aimed to analyze research trends related to physicians’ competency in reflecting social needs according to changes in the medical environment.

Methods
We used topic modeling to identify potential research topics by analyzing data from studies related to physician competency published between 2011 and 2020. We preprocessed 1354 articles and extracted 272 keywords.

Results
The terms that appeared most frequently in the research related to physician competency since 2010 were knowledge, hospital, family, job, guidelines, management, and communication. The terms that appeared in most studies were education, model, knowledge, and hospital. Topic modeling revealed that the main topics about physician competency included Evidence-based clinical practice, Community-based healthcare, Patient care, Career and self-management, Continuous professional development, and Communication and cooperation. We divided the studies into 4 periods (2011-2013, 2014-2016, 2017-2019, and 2020-2021) and performed a linear regression analysis. The results showed a change in topics by period. The hot topics that have shown increased interest among scholars over time include Community-based healthcare, Career and self-management, and Continuous professional development.

Conclusions
On the basis of the analysis of research trends, it is predicted that physician professionalism and community-based medicine will continue to be studied in future studies on physician competency.
Eksistensi dan Ancaman Usaha Pegaraman di Gampong Cebrek Kabupaten Pidie
Authors: Nurdin Ibnu Phonna , Fatia Dara , Chairunnisak Cut Lusi 
Published: May 2023

Barriers in salt farming endeavors are constantly encountered by salt farming communities, thereby impacting the future sustainability of salt production. This article aims to describe the sustainability threats posed by traditional salt farming activities in Gampong Cebrek, Simpang Tiga Subdistrict, Pidie Regency. The article presents findings from a qualitative field research conducted using observational data and in-depth interviews with selected traditional salt farmers employing purposive sampling technique. The study reveals that the existence of traditional salt farming activities in Gampong Cebrek, Pidie Regency, is confronted with several issues that could potentially jeopardize their future existence. Firstly, the regeneration process of salt farmers is not progressing effectively. Secondly, the declining participation and capabilities of salt farmers due to their advanced age. Thirdly, government policies have led to a decrease in production and distribution of salt. Lastly, the conversion of agricultural land into residential areas has occurred.
Abstrak
Hambatan dalam usaha pegaraman selalu terjadi pada komunitas petani garam yang berdampak pada keberlanjutan usaha garam di masa mendatang. Artikel ini bertujuan untuk mendeskripsikan tentang ancaman keberlanjutan dari aktivitas pertanian garam tradisional di Gampong Cebrek, Kecamatan Simpang tiga, Kabupaten Pidie. Artikel ini merupakan hasil penelitian lapangan menggunakan metode kualitatif. Data diperoleh dari hasil observasi dan wawancara mendalam kepada petani garam tradisional yang dipilih menggunakan teknik purposive. Kajian ini menunjukkan bahwa eksistensi aktivitas pertanian garam tradisional di Gampong Cebrek Kabupaten Pidie dihadapkan pada beberapa persoalan yang kemudian dapat mengancam eksistensi mereka di masa mendatang. Pertama, proses regenerasi pertani garam yang tidak berjalan dengan baik. Kedua, partisipasi dan kemampuan petani garam yang semakin menurun karena telah memasuki usia senja. Ketiga, kebijakan pemerintah yang berdampak pada menurunnya aktivitas produksi dan distribusi garam. Keempat, terjadinya alih fungsi lahan pertanian menjadi lahan pemukiman.
SOCIEDADE E TRABALHO IMATERIAL ECONOMIA CRIATIVA NAS COMUNIDADES POPULARES
Authors: Cavalcanti Marcus Alexandre de Pádua , Cavalcanti Eliane Cristina Tenório 
Published: May 2023

O artigo propõe analisar o trabalho imaterial e a economia criativa da moda que emerge de grupos subalternos, sendo posteriormente adotados ou imitados por grupos hegemônicos. Nesse sentido, o trabalho ganha nova dinâmica, mesmo que ainda precária, integrando, mesmo que de forma subordinada, comunidades ao mercado. O artigo utiliza o conceito de economia criativa e distinção analítica entre trabalho material e imaterial, compreendendo que este processo de produção tem dupla dimensão. A produção material se refere ao objeto produzido, enquanto que a produção imaterial é intangível e se refere à criação e ao design do produto. Tal distinção tem como objetivo discutir as tensões existentes por conta das aproximações entre o design de moda comercializado em boutiques de luxo e o trabalho realizado por produtores que trabalham em oficinas artesanais localizadas em comunidades. O estudo é de abordagem qualitativa, onde utilizaremos a pesquisa bibliográfica.
A FORÇA DE CRIAÇÃO DA PALAVRA COMO ELO ENTRE CLARICE LISPECTOR E AS LITERATURAS AFRICANAS
Authors: Coutinho Rhanica Evelise Toledo , Oliveira Gabriela de Castro Maciel de 
Published: May 2023

Esta pesquisa se dispõe a estudar a aproximação que a perspectiva da força de criação da palavra, objeto desse estudo, permite entre a literatura de Clarice Lispector e o pensamento de filósofos africanos que estudaram a literatura deste continente. Sendo assim, busca-se, com este trabalho, esclarecer, apesar das disparidades do seu contexto de produção ou forma (caráter oral ou escrito), de que maneira essas literaturas se aproximam. Tal aproximação foi feita seguindo uma lógica de comparação que respeita as semelhanças e distanciamentos entre os dois contextos, de produção e cultural, e textos literários, utilizando-se, para isso, trechos da obra de Clarice Lispector, de filósofos africanos e críticos literários, ao que comprovou-se que ambas literaturas partilham a concepção cultural da força de criação da palavra, a qual também encontra correspondência nos mitos de criação em que cada produção está inserida, ainda que tratem-se de religiões e conjunturas distintas; dessa forma, verificou-se que tanto Clarice quanto escritores africanos encontraram no poder de criação da palavra a possibilidade de manterem-se vivos e efetivar sua expressão enquanto ser humano, já que ambos reconhecem que a linguagem não é mero instrumento de comunicação, mas conforme o ilustrado em suas origens culturais e ao longo dos movimentos de resistência empregados nos dois casos, uma extensão do homem e a força que gerou tudo o que existe. Portanto, no que diz respeito, no caso da literatura africana, à luta pelo não desaparecimento de sua cultura original, outrora massacrada pela colonização europeia; e em Clarice Lispector, à compreensão de si mesma e da essência universal humana, a palavra e sua força de criação foi o que permitiu uma exteriorização bem sucedida de suas próprias forças e capacidade de recriarem-se.