bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fractionated Radiotherapy After Gross Total Resection of Clival Chordoma: A Systematic Review of Survival Outcomes
Authors: Gendreau Julian L. , Hameed N. U. Farrukh , Jimenez Adrian , Chakravarti Sachiv , Mehkri Yusuf , Mukherjee Debraj 
Published: February 2023

BACKGROUND:
Current treatment guidelines for clival chordomas recommend surgical resection followed by high-dose radiotherapy (RT). However, in patients in whom gross total resection (GTR) is achieved, the benefits of additional RT remain unclear.

OBJECTIVE:
To investigate whether RT offers any benefit to progression-free survival (PFS) in patients undergoing GTR of clival chordoma by performing a systematic review of all currently published literature.

METHODS:
A total of 5 databases were searched to include all studies providing data on GTR ± RT for clival chordomas (January 1990-June 2021). Qualitative assessment was performed with Newcastle–Ottawa Scale guidelines for assessing quality of nonrandomized studies. Statistical analysis using individualized patient data of PFS was performed.

RESULTS:
The systematic search yielded 2979 studies, weaned to 22 full-text articles containing 108 patients. All patients underwent GTR of clival chordoma, with 46 (43%) patients receiving adjuvant RT. Mean PFS for RT patients was 31.09 months (IQR: 12.25-37.75) vs 54.92 months (IQR: 14.00-85.75) in non-RT patients. Overall, RT did not increase PFS (HR 0.320, P = .069) to a value that achieved statistical significance. Stratifying by photon therapy vs particle beam therapy yielded no statistically significant benefit for particle beam therapy for PFS (P = .300). Of patients with age ≥65 years, RT did not improve outcomes to statistical significance for PFS (HR 0.450, P = .481). Patients age ≥65 years had lower PFS on both bivariate analysis (HR 3.708, P = .007) and multivariate analysis (HR 3.322, P = .018).

CONCLUSION:
After achieving GTR of clival chordoma, fractionated RT offers unclear benefit upon survival outcomes.
Classification and Management Considerations for Intraosseous Dural Arteriovenous Fistulae
Authors: Howard Brian M. , Manupipatpong Sasicha , Dion Jacques E. , Tamargo Rafael J. , Gailloud Philippe , Hui Ferdinand K. 
Published: February 2023

BACKGROUND:
Intraosseous dural arteriovenous fistulas (IODAVFs) are rare DAVFs that communicate with marrow. Given their infrequency, common nomenclature is nonexistent. Patients may present with benign symptoms, such as tinnitus, or venous hypertension symptoms including hemorrhage depending on the venous outflow pattern.

OBJECTIVE:
To describe all available cases of IODAVF in the literature, in addition to our cases, to better define presentation, and treatment outcomes. To advance a classification system to develop common language for these lesions for clinicians and researchers.

METHODS:
Neurointerventional procedure logs at 2 high-volume neurovascular centers were reviewed for all cases of IODAVFs, as was the English-based literature available in PubMed. The angioarchitecture, symptoms, management, and demographics were reviewed and summarized.

RESULTS:
Four institutional cases were identified, 2 of which had shunting within the marrow (clival or petrous), with venous drainage toward the heart. One case involved the dorsum sella with drainage into the superior petrosal sinus with reflux into the anterior and posterior spinal venous plexuses, and one involved the left petroclival junction, resulting in communication with the cavernous sinus with retrograde drainage into the superior ophthalmic veins. Two patients were managed by observation, one was treated with radiosurgery and one with microsurgical skeletonization. Twenty additional cases from the literature are summarized.

CONCLUSION:
IODAVFs of the cerebrocranial vasculature may present incidentally, with tinnitus, or with symptoms related to mass effect or venous hypertension. We propose a classification which accounts for drainage patterns. Further study is needed for these rare lesions.
SUN4 is a spermatid type II inner nuclear membrane protein that forms heteromeric assemblies with SUN3 and interacts with lamin B3
Authors: Thoma Hanna , Grünewald Luisa , Braune Silke , Pasch Elisabeth , Alsheimer Manfred 
Published: February 2023

ABSTRACT
SUN domain proteins are conserved proteins of the nuclear envelope and key components of the LINC complexes (for ‘linkers of the nucleoskeleton and the cytoskeleton’). Previous studies have demonstrated that the testis-specific SUN domain protein SUN4 (also known as SPAG4) is a vital player in the directed shaping of the spermatid nucleus. However, its molecular properties relating to this crucial function have remained largely unknown, and controversial data for the organization and orientation of SUN4 within the spermatid nuclear envelope have been presented so far. Here, we have re-evaluated this issue in detail and show robust evidence that SUN4 is integral to the inner nuclear membrane, sharing a classical SUN domain protein topology. The C-terminal SUN domain of SUN4 localizes to the perinuclear space, whereas the N-terminus is directed to the nucleoplasm, interacting with the spermiogenesis-specific lamin B3. We found that SUN4 forms heteromeric assemblies with SUN3 in vivo and regulates SUN3 expression. Together, our results contribute to a better understanding of the specific function of SUN4 at the spermatid nucleo-cytoplasmic junction and the process of sperm-head formation.
The perceived impact of the COVID-19 pandemic on medical students’ future careers
Authors: Mahjoub Heba , Vasavda Chirag , Bertram Amanda , Davison Ashwini , Sozio Stephen 
Published: February 2023

Background: The COVID-19 pandemic disrupted medical education on multiple levels, and medical students have been forced to adjust to distance learning, altered clinical opportunities, and standardized testing inconsistencies. We sought to identify the effects of these dramatic deviations on medical students’ career plans. Methods: We conducted a cross-sectional online survey of medical students between July 13, 2020, and September 9, 2020 in order to assess the implications of the COVID-19 pandemic on students’ career decisions. Descriptive statistics were calculated for all variables. Results: Of the 585 eligible medical students, we had a final sample of 76 responses (n=76) (13% response rate). Students felt neutral regarding having more time to explore research projects (Mean ± SD; 3.06 ± 1.18) and hobbies (3.43 ± 1.28). Most survey respondents somewhat disagreed that they considered quitting medical school during the pandemic (1.55 ± 1.10). Students somewhat agreed that they view the field of medicine more positively since the onset of the COVID-19 pandemic (3.60 ± 1.09). Respondents somewhat agreed that they would be unable to explore other specialties and find their best fit (3.55 ± 1.32). We found that the minority (4/66, 6%) of students had considered changing their specialty. Students felt neutral in terms of their Step 1 (3.25 ± 1.05) or Step 2 (2.81 ± 1.02) score deterring them from future career opportunities. Conclusions: Most medical students have experienced barriers in their career pathway as a direct cause of COVID-19 restrictions on medical education, including the ability to explore different specialties to discover their best fit or find a chance to network with mentors. However, despite these obstacles, most students remain committed to medicine.
AUTOMATED UML MODEL COMPARISON FOR QUALITY ASSURANCE IN SOFTWARE ENGINEERING EDUCATION
Authors: Stefan Florea , Cernian Alexandra , Ionita Anca daniela 
Published: February 2023

Quality assurance in educational institutions should include mechanisms for detecting any student's attempt to cheat at his or her written assessments. Due to an increasing number of incidents, it is necessary to define holistic approaches at institutional levels, where management, culture and infrastructure should be taken into account. For this purpose, universities generally use tools for detecting plagiarism, based on comparing text and grammatical style, as well as searching for similar materials available on the Internet. Apart from general systems for detecting plagiarism, each discipline may require specific electronic aids for identifying similarities between assessment results.	The paper considers the case of Software Engineering and, more specifically, Object-Oriented Modeling. It proposes solutions for automatically comparison of models conforming to the Unified Modeling Language, based on the following requirements:
-	Define methods for comparing all types of diagrams;
-	Develop a system that stores students' models;
-	Create tools that check a new project upon all the previous submissions, in order to detect similarities;
-	Eliminate false positive results;
-	Introduce the facility to detect synonyms at the level of modeling element names, using a Romanian language dictionary;
-	Define metrics for the similarity degree;
-	Validate the methods and tools in the classroom.
The UML diagrams are supposed to be represented with the open source platform StarUML; then, they are exported to XML format for being interpreted and analyzed in comparison with the models of the central repository; one also checks for synonyms in naming modeling elements like classes, attributes, operations, actors, activities, states, components, nodes etc. The similarity score is computed with a dedicated algorithm, which takes into account weighted UML elements, UML relations, and semantics synonymy aspects.
WEBUNIV - COLLABORATIVE SUPPORT SYSTEMS FOR EDUCATION
Authors: Pop Dragos paul , Chichernea Virgil 
Published: February 2023

The development of IT&C technology, from "e" to "m" and "i" in the digital era has been the major challenge for both the modernization of the training and teaching process and for the management and scientific research of this process. The infrastructure of Collaborative Support Systems for Education (Document management systems, Process Management Systems, Conferencing tools, Recording/streaming tools, Virtual workspaces, Workflow systems, Web design tools, Meeting room technologies, Learning systems(organizational learning, educational tool, etc.), Development tools) and their main architectural modules recommends these systems as a technical solution capable of contributing to the solution of the complex issues found in education. This paper covers the main architectural and functional modules of a proposed Collaborative Support System (CSS, Integrated University Information System), based on Web technologies as well as the current usage scenarios in the university environment. It also deals with an evaluation of the impact of this system on specific activities of the education process in universities, the management of this complex process and an estimation of future usage scenarios for these systems in cloud computing. The structure and functions of this CSS are the following: WebBoard - software systems for creating and managing timetables, course assignments, physical room management; StudyCentral - training content specific to subjects found in the curricula, organized according to schools, study years, subjects, that contains teaching material in digital form (curricula, courses, case study and project books, self-testing collections, examination tests);i-Click - a virtual interactive environment used to track the conveyance of information, testing and managing student activities and attendance during the semester for all subjects in the curricula;	LearnBase - Integrated information system used to manage the whole teaching process, which includes: student databases, grade management, student transcripts, statistics; CloudSpace - Cloud-based service that allows document and project sharing and real-time collaboration between students and teachers in an online environment.
EDUCATIONAL SOFTWARE FOR WOVEN FABRICS DESIGN
Authors: Cioara Lucica , Cioara Ioan 
Published: February 2023

The software proposed in this paper presents an educational teaching method of the woven fabrics with simple structure.
The program is modular designed with increasing difficulty while the complexity of the approached subject increases. The program respects the principles of the educational methology and the information is presented gradual so that good knowledge assimilation is possible.
It is based on the teaching method used by the professors from this branch and follows the steps of the learning process..
The software is useful to all who attend "The structure of woven fabrics" subject, both in high schools and universities.
Each modul is repesentatif for the educational program levels (high schools or universities)
The successive modules are designed taking into account the classification of the weave for the simple woven fabrics.
When designing the program three main directions have been followed:
-	establishment of the educational methodology (the teaching and testing methods);
-	analysis and systematization of the structural and appearance characteristics that define the woven fabrics for fundamental weaves, derivative weaves and combined weaves;
-	establishment of the elements that will be used in testing the knowledge and also the testing steps.
From the educational point of view are respected the specific steps of learning and testing the knowledge. So, the program can be used in LEARNING and respectively TESTING variant. The user have to choose one of these options at the beginning of the work session.
The applicant has to introduce himself the needed structure characteristics for a certain weave.
The program allows the individual study and individual estimate of knowledge.
DEVELOPING AND MANAGING SUCCESSFUL LANGUAGE PROJECTS
Authors: Colibaba Anca cristina , Colibaba Stefan , Ionel Andreea corina , Colibaba Cintia 
Published: February 2023

Nellip (Network of European Language Labelled Initiatives, funded by the European Commission in the framework of the Lifelong Learning Programme - Key Activity 2 Languages) is the largest repository of case studies about exemplary projects awarded with the distinction European Language Label for quality and innovative language teaching in Europe. This EU diachronic collection of case studies is organised in order to support a collective European reflection on transferable lessons about the following key elements: socio-educational needs in connection to language learning, quality of language education, innovation as a tool to support the first two elements.
The main objectives envisaged are: to promote the networking and creation of synergies among language learning initiatives having received the European Language Label with the aim to enhance their impact, transferability potential and sustainability; to promote the adoption of a joint methodology that will allow the effective planning and implementation of high quality language learning initiatives according to the quality criteria used for the assessment of initiatives that apply to be awarded the European Language Label; and	to promote the information about the European Language Label initiative among language learning providers (Universities, schools, adult education institutions, vocational education and training providers).
Within this article we will reflect on and share experience about what constitutes a successful, high quality language project, learning about the European Language Label scheme and about the application process and the criteria used to select projects for an award. Revealing the results of the international workshops organized in order to test and exploit project results.
ANALYSIS OF THE EFFICIENCY OF DIFFERENT SYSTEMS OF STATISTICAL ANALYSIS USED IN FOOTBALL, ON THE LEVEL OF 1ST LEAGUE, IN ROMANIA
Authors: Cojocaru Viorel , Cojocaru Viorel , Panait Ciprian 
Published: February 2023

The football game has become a real social phenomenon and an industry, at the same time.
Turning this game in what it has become today has been possible based on using, in trainings and games, the latest information provided by the new systems of analysis and statistics, which allowed the deep knowledge of the components of the performance pattern.
Out of the multitude of information acquired following the statistic analysis of the I League official games, we may assert that a quite advanced level of knowledge has been reached, allowing an objective and efficient orientation of the training process, so that the victories obtained in the official games should be a consequence of the trainings correctly designed and adapted according to the features of their own players, but also of the opponents.
PANINI DIGITALSOCCER PROJECT submits to our attention a series of information and basic indexes referring to the global evolution of the teams, as well as an individualized analysis of the players and of the technical-tactical behavior. All this information is graphically structured and graded per time units (halves). Thus, this system provides general notions and groups the information according to the moments of the game (attack-defense), as follows:
-	General notions: game volume, ball circulation, game quality, positioning in the field;
-	Defensive stage: attitude, take back the ball, defense of their own goalpost;
-	Offensive stage: beginning of the action, play depth, game on sideways, etc;
InStat Football, a new system of analysis and statistics used in the last years by the coaches and analysts of I League, proposes us a complex approach of the gathered information, as follows:
-	General information, presented "in the mirror", concerning the overall evolution of the teams: actions, duels, passages, possession, attacks; this information is structured per time but, most importantly, per field areas;
-	Information on the evolution of each player, individually analyzed, but by comparison to the opponent player, who played on the same position;
Both systems of analysis provide sufficient and objective information, but we propose to determine the system that structures data in such manner so that they should not be mere statistic information, but also to determine the coach/analysis to reach fast and clear conclusions concerning the team's training in order to win the future match.
COREL VIDEO STUDIO PRO PROGRAM, A MODERN TOOL IN THE TACTICAL ANALYSIS IN PROFESSIONAL FOOTBALL
Authors: Panait Ciprian 
Published: February 2023

Knowing the opponent has become in today's football a condition as important as the training of one's own team, in order to obtain results.
Until not so long ago, the team's evolution in the official games was analyzed by common video means (video-player VHS, cd-player), and supposed a viewing, within the group, of the game played in the previous stage.
The analysis is performed with great difficulty, due to the technical solutions provided by the existing devices. Technically, during this viewing, the entire game was reviewed, with very many interruptions, caused by the need to identify on the image all the aspects considered important in the evolution of the team and of the players, individually, each on their positions. Thus, the "STOP-REPLAY-PLAY, ONCE AGAIN!" moments repeated with very high frequency, leading to the following consequences:
-	Minimum efficiency, caused by the impossibility to efficiently extract the information and images occurring in the decisive moment in the development of the game, with direct consequences on the final outcome;
-	Large time budget allocated to the analysis: the analysis of the entire game required approximately two hours;
-	The impossibility to keep the players' attention and focus for such a long period of time;
Technically in this working manner we cannot speak of a professional analysis of the game and of the players, but rather of a viewing during which the players and the coaches "comment" on what they see in the images.
The need to rapidly and efficiently identify the tactical actions that have been determining during the game is satisfied by the Corel Video Studio Pro program, which gives us the possibility of a decisive technological leap in performing a professional tactic analysis.
Through our research we propose to establish the positive influences of using this analysis program, influences which have direct implications in determining the final outcome of the official game.
FACING ETHICAL CHALLENGES IN THE PROVISION OF ELEARNING BY ROMANIAN HEIS
Authors: Ciachir Lilian , Vochin Oana alexandra , Motataianu Alexandru 
Published: February 2023

According to the EU 2020 strategy, one of the objectives for Romania in the field of education is that at least 40% of the population aged 30 to 34 years to complete tertiary education (university and non-university). In 2013-2014 only 23.8 % of the population is in this situation and the goal set was to reach 26.7%.
Due to the fact that the number of pre-university students is estimated to decrease by 40% between 2005 and 2025, the number of traditional students is also declining. Second chance education could be considered as a solution to tackle the discrepancy between the policy goal and the real trend observed in the last few years, and eLearning appears to be an appropriate medium to encourage non-traditional students to enrol for further education and successful finish tertiary education.
In Romania, only about 60% of universities are involving eLearning solutions in their current education offer. On the other hand, for the moment being, there is no Romanian HEI offering full eLearning study programs. However, there is a great diversity in Romania combining face-to-face with elements of bended learning and eLearning.
Romanian universities have always been concerned with ethical aspects of their activities and many of them adopted codes of moral or ethical conduct. In some universities the principles of ethical conduct are implicit provisions of their charts or mission statements (e.g. Transilvania University of Brasov or West University of Timi?oara).
As the practice of eLearning is becoming increasingly applicable in the study programs offered by Romanian universities, the ethical dimensions of the student-teacher relationship and the responsibility for the quality of learning outcomes turns into a real challenge:
-	Students for cheating and plagiarism attempts;
-	Professors for their responsibility in quality assurance of the educational resources for eLearners;
-	Students and professors for their co-responsibility for the quality and relevance of the eLearning outcomes.
As the Romanian society perceives high corruption in individual and institutional behaviour, the ethical challenges in the field of higher education merit a closer attention. Another strong argument is offered by the frequent complaints of plagiarism in doctoral theses, which let us understand that in lower levels of higher education there are also practices against the code of ethical conduct adopted in HEIs. In this context, examples of good practice in overcoming ethical shortages in the provision of eLearning and in the evaluation of the learners should become a focus point in preparing for enhanced eLearning and blended learning (UK, etc).
The purpose of this article is to analyse the status quo of the ethical challenges in the provision of eLearning by Romanian HEIs and to suggest recommendations to solve existing or potential ethical problems in the delivery of blended and or eLearning programs.