bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemonitoring for heart failure: a meta-analysis
Authors: Scholte Niels T B , Gürgöze Muhammed T , Aydin Dilan , Theuns Dominic A M J , Manintveld Olivier C , Ronner Eelko , Boersma Eric , de Boer Rudolf A , van der Boon Robert M A , Brugts Jasper J 
Published: May 2023

Abstract

Aims
Telemonitoring modalities in heart failure (HF) have been proposed as being essential for future organization and transition of HF care, however, efficacy has not been proven. A comprehensive meta-analysis of studies on home telemonitoring systems (hTMS) in HF and the effect on clinical outcomes are provided.

Methods and results
A systematic literature search was performed in four bibliographic databases, including randomized trials and observational studies that were published during January 1996–July 2022. A random-effects meta-analysis was carried out comparing hTMS with standard of care. All-cause mortality, first HF hospitalization, and total HF hospitalizations were evaluated as study endpoints. Sixty-five non-invasive hTMS studies and 27 invasive hTMS studies enrolled 36 549 HF patients, with a mean follow-up of 11.5 months. In patients using hTMS compared with standard of care, a significant 16% reduction in all-cause mortality was observed [pooled odds ratio (OR): 0.84, 95% confidence interval (CI): 0.77–0.93, I2: 24%], as well as a significant 19% reduction in first HF hospitalization (OR: 0.81, 95% CI 0.74–0.88, I2: 22%) and a 15% reduction in total HF hospitalizations (pooled incidence rate ratio: 0.85, 95% CI 0.76–0.96, I2: 70%).

Conclusion
These results are an advocacy for the use of hTMS in HF patients to reduce all-cause mortality and HF-related hospitalizations. Still, the methods of hTMS remain diverse, so future research should strive to standardize modes of effective hTMS.
Conventional heart failure therapy in cardiac ATTR amyloidosis
Authors: Ioannou Adam , Massa Paolo , Patel Rishi K , Razvi Yousuf , Porcari Aldostefano , Rauf Muhammad U , Jiang Anita , Cabras Giacomo , Filisetti Stefano , Bolhuis Roos E , Bandera Francesco , Venneri Lucia , Martinez-Naharro Ana , Law Steven , Kotecha Tushar , Virsinskaite Ruta , Knight Daniel S , Emdin Michele , Petrie Aviva , Lachmann Helen , Wechelakar Ashutosh , Petrie Mark , Hughes Alun , Freemantle Nick , Hawkins Philip N , Whelan Carol , McMurray John J V , Gillmore Julian D , Fontana Marianna 
Published: May 2023

Abstract

Aims
The aims of this study were to assess prescription patterns, dosages, discontinuation rates, and association with prognosis of conventional heart failure medications in patients with transthyretin cardiac amyloidosis (ATTR-CA).

Methods and results
A retrospective analysis of all consecutive patients diagnosed with ATTR-CA at the National Amyloidosis Centre between 2000 and 2022 identified 2371 patients with ATTR-CA. Prescription of heart failure medications was greater among patients with a more severe cardiac phenotype, comprising beta-blockers in 55.4%, angiotensin-converting enzyme inhibitors (ACEis)/angiotensin II receptor blockers (ARBs) in 57.4%, and mineralocorticoid receptor antagonists (MRAs) in 39.0% of cases. During a median follow-up of 27.8 months (interquartile range 10.6–51.3), 21.7% had beta-blockers discontinued, and 32.9% had ACEi/ARBs discontinued. In contrast, only 7.5% had MRAs discontinued. A propensity score-matched analysis demonstrated that treatment with MRAs was independently associated with a reduced risk of mortality in the overall population [hazard ratio (HR) 0.77 (95% confidence interval (CI) 0.66–0.89), P &lt; .001] and in a pre-specified subgroup of patients with a left ventricular ejection fraction (LVEF) &gt;40% [HR 0.75 (95% CI 0.63–0.90), P = .002]; and treatment with low-dose beta-blockers was independently associated with a reduced risk of mortality in a pre-specified subgroup of patients with a LVEF ≤40% [HR 0.61 (95% CI 0.45–0.83), P = .002]. No convincing differences were found for treatment with ACEi/ARBs.

Conclusion
Conventional heart failure medications are currently not widely prescribed in ATTR-CA, and those that received medication had more severe cardiac disease. Beta-blockers and ACEi/ARBs were often discontinued, but low-dose beta-blockers were associated with reduced risk of mortality in patients with a LVEF ≤40%. In contrast, MRAs were rarely discontinued and were associated with reduced risk of mortality in the overall population; but these findings require confirmation in prospective randomized controlled trials.
How to sample a seizure plant: the role of the visualization spatial distribution analysis of Lophophora williamsii as an example
Authors: Lin Jiaman , Yun Keming , Sun Qiran , Xiang Ping , Wu Lina , Yang Shuo , Dun Junling , Fu Shanlin , Chen Hang 
Published: May 2023

Abstract

Natural compounds in plants are often unevenly distributed, and determining the best sampling locations to obtain the most representative results is technically challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can provide the basis for formulating sampling guideline. For a succulent plant sample, ensuring the authenticity and in situ nature of the spatial distribution analysis results during MSI analysis also needs to be thoroughly considered. In this study, we developed a well-established and reliable MALDI-MSI method based on preservation methods, slice conditions, auxiliary matrices, and MALDI parameters to detect and visualize the spatial distribution of mescaline in situ in Lophophora williamsii. The MALDI-MSI results were validated using liquid chromatography–tandem mass spectrometry. Low-temperature storage at −80°C and drying of “bookmarks” were the appropriate storage methods for succulent plant samples and their flower samples, and cutting into 40 μm thick sections at −20°C using gelatin as the embedding medium is the appropriate sectioning method. The use of DCTB (trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile) as an auxiliary matrix and a laser intensity of 45 are favourable MALDI parameter conditions for mescaline analysis. The region of interest semi-quantitative analysis revealed that mescaline is concentrated in the epidermal tissues of L. williamsii as well as in the meristematic tissues of the crown. The study findings not only help to provide a basis for determining the best sampling locations for mescaline in L. williamsii, but they also provide a reference for the optimization of storage and preparation conditions for raw plant organs before MALDI detection.

Key Points
TRI-SCORE: a single-centre validation study
Authors: Sala Alessandra , Carino Davide , Lorusso Roberto , Zancanaro Edoardo , Bargagna Marta , Del Forno Benedetto , Trumello Cinzia , Denti Paolo , Ruggeri Stefania , Nonis Alessandro , Scarale Maria Giovanna , Schiavi Davide , Castiglioni Alessandro , Maisano Francesco , Alfieri Ottavio , De Bonis Michele 
Published: May 2023

Abstract

OBJECTIVES
The TRI-SCORE is a recently published risk score for predicting in-hospital mortality in patients undergoing isolated tricuspid valve surgery (ITVS). The aim of this study is to externally validate the ability of the TRI-SCORE in predicting in-hospital and long-term mortality following ITVS.

METHODS
A retrospective review of our institutional database was carried out to identify all patients undergoing isolated tricuspid valve repair or replacement from March 1997 to March 2021. The TRI-SCORE was calculated for all patients. Discrimination of the TRI-SCORE was assessed using receiver operating characteristic curves. Accuracy of the models was tested calculating the Brier score. Finally, a COX regression was employed to evaluate the relationship between the TRI-SCORE value and long-term mortality.

RESULTS
A total of 176 patients were identified and the median TRI-SCORE was 3 (1–5). The cut-off value identified for increased risk of isolated ITVS was 5. Regarding in-hospital outcomes, the TRI-SCORE showed high discrimination (area under the curve 0.82), and high accuracy (Brier score 0.054). This score showed also very good performance in predicting long-term mortality (at 10 years, hazard ratio: 1.47, 95% confidence interval [1.31–1.66], P &lt; 0.001), with high discrimination (area under the curve &gt;0.80 at 1–5 and 10 years) and high accuracy values (Brier score 0.179).

CONCLUSIONS
This external validation confirms the good performance of the TRI-SCORE in predicting in-hospital mortality. Moreover, the score showed also very good performance in predicting the long-term mortality.
A fully mixed virtual element method for Darcy–Forchheimer miscible displacement of incompressible fluids appearing in porous media
Authors: Dehghan Mehdi , Gharibi Zeinab 
Published: May 2023

AbstractThe incompressible miscible displacement of two-dimensional Darcy–Forchheimer flow is discussed in this paper, and the mathematical model is formulated by two partial differential equations, a Darcy–Forchheimer flow equation for the pressure and a convection–diffusion equation for the concentration. The model is discretized using a fully mixed virtual element method (VEM), which employs mixed VEMs to solve both the Darcy–Forchheimer flow and concentration equations by introducing an auxiliary flux variable to ensure full mass conservation. By using fixed point theory, we proved the stability, existence and uniqueness of the associated mixed VEM solution under smallness data assumption. Furthermore, we obtain optimal error estimates for concentration and auxiliary flux variables in the $\texttt {L}^{2}$- and $\textbf {L}^{2}$-norms, as well as for the velocity in the $\textbf {L}^{2}$-norm. Finally, several numerical experiments are presented to support the theoretical analysis and to illustrate the applicability for solving actual problems.
Quantum Automorphism Groups of Connected Locally Finite Graphs and Quantizations of Discrete Groups
Authors: Rollier Lukas , Vaes Stefaan 
Published: May 2023

Abstract
We construct for every connected locally finite graph $\Pi $ the quantum automorphism group $\operatorname{QAut} \Pi $ as a locally compact quantum group. When $\Pi $ is vertex transitive, we associate to $\Pi $ a new unitary tensor category ${\mathcal{C}}(\Pi )$ and this is our main tool to construct the Haar functionals on $\operatorname{QAut} \Pi $. When $\Pi $ is the Cayley graph of a finitely generated group, this unitary tensor category is the representation category of a compact quantum group whose discrete dual can be viewed as a canonical quantization of the underlying discrete group. We introduce several equivalent definitions of quantum isomorphism of connected locally finite graphs $\Pi $, $\Pi ^{\prime}$ and prove that this implies monoidal equivalence of $\operatorname{QAut} \Pi $ and $\operatorname{QAut} \Pi ^{\prime}$.
International Studies and Struggles for Inclusion
Authors: Chadi Tarik Abou , Bond Kanisha D , Dorff Cassy , Hagen Jamie , Hendrix Cullen S , Thies Cameron 
Published: May 2023

Abstract
In the 3 years between the 2019 and 2022 International Studies Association (ISA) meetings, the profound state of global economic, social, and political upheaval around the world has become unavoidably evident for much, if not most, of the world. Against the backdrop of the COVID-19 pandemic, movements for inclusion and resulting backlashes sprang up across the globe. As scholars of international affairs, the members of the ISA seek to understand and contextualize world events. However, our members and the organization itself are not passive observers of history. These struggles directly influence the personal experiences of many of our members, within and beyond our profession. For these reasons, ISA leadership felt that it was important to mark the 2022 meeting with a Sapphire Series panel to discuss ``International Studies and Struggles for Inclusion.'' The panel brought together ISA members from various sections and backgrounds to offer diverse perspectives on a host of topics: How does the field of international studies understand these developments? How do struggles for inclusion affect our members and community of social scientists? And perhaps most importantly, what should the ISA be doing about them, in terms of both scholarship and organizational decisions?
Treatment decisions in VRE bacteraemia: a survey of infectious diseases pharmacists
Authors: White Bryan P , Barber Katie E , Chastain Daniel B 
Published: May 2023

Abstract

Background
VRE infections increased in 2020. High-dose daptomycin (≥10 mg/kg) has shown mortality benefit over other regimens, though daptomycin resistance is increasing. Limited data exist on the practice patterns of ID pharmacists for VRE bloodstream infections (VRE BSIs).

Objectives
To describe practice patterns for VRE BSI in ID pharmacists.

Methods
A 22-question REDCap survey was distributed to ID pharmacist members of the American College of Clinical Pharmacy (ACCP) Infectious Diseases Practice and Research Network (ID PRN) via e-mail listserv. The survey was distributed on 7 April 2022 and remained open for 4 weeks.

Results
Sixty-eight pharmacists responded. All pharmacists completed additional training or certification in infectious diseases past their PharmD, and most (70.5%) had been practising for 10 years or less. Pharmacists at academic medical centres (80.0%) were more likely (P = 0.001) to have implemented the updated CLSI breakpoints than pharmacists at other types of institutions (55.2%). Daptomycin was the preferred drug for VRE BSI (92.6%), with 10 mg/kg (72.1%) being the preferred dose. Adjusted body weight was the most common weight (61.2%) used for obese patients. Fourteen days (76.1%) was the most common treatment duration for VRE BSI. Pharmacists defined persistent VRE BSI as 5 days (68.7%) after first blood culture.

Conclusions
ID pharmacists overwhelmingly selected high-dose daptomycin for VRE BSI. There were variations in practice and response rate when selecting combination therapy, managing persistent bacteraemia, and treating patients with high daptomycin MICs or previous exposure to daptomycin.
Impact of shade in beef feedyards on performance, ear temperature, and heat stress measures
Authors: Winders Thomas M , Melton Brett A , Boyd Bradley M , Macken Casey N , Watson Andrea K , MacDonald James C , Erickson Galen E 
Published: May 2023

Abstract
A 2-yr study (year 1: March to September 2017; year 2: February to August 2018) was conducted using crossbred steers (year 1: n = 1677; initial body weight [BW] = 372 kg, SD = 47; year 2: n = 1713; initial BW = 379 kg, SD = 10) in a commercial feedyard study in Eastern NE to determine the effects of shade on cattle performance, ear temperature, and cattle activity. Two treatments were evaluated using a randomized complete block design (n = 5 blocks based on arrival). Treatments were assigned randomly to pens and consisted of five pens without shade (NO SHADE) and five pens with shade (SHADE). Ear temperatures were collected throughout the trials using biometric sensing ear tags on a subset of cattle. Panting scores were collected using a 5 point scale determined visually based on the level of panting occurring on the same subset of steers a minimum of twice weekly from June 8 to August 21 in year 1 and May 29 to July 24 in year 2 by one trained individual each year. In year 1, no differences (P ≥ 0.24) were observed for growth performance or carcass characteristics. Dry matter intake (DMI) and average daily gain (ADG) were greater (P ≤ 0.04) for SHADE cattle in year 2. Over the entire feeding period in year 1, greater (P &lt; 0.01) ear temperature was observed for NO SHADE cattle, but cattle movement was not different (P = 0.38) between treatments. When evaluating the entire feeding period in year 2, cattle movement and ear temperature were not different (P ≥ 0.80) between treatments. Cattle in the SHADE treatment had lower (P ≤ 0.04) panting scores in years 1 and 2. These data suggest that providing shade can lessen the negative influence of heat events on DMI and was an effective way to reduce heat stress in feedlot operations, but only impacted ADG if heat events were close to the cattle slaughter date.
Life-table parameters of Plodia interpunctella (Lepidoptera: Pyralidae) on different stored date palm fruits under laboratory conditions
Authors: Jaafari-Behi Vahid , Ziaee Masumeh , Kocheili Farhan , Ali Hemmati Seyed , Francikowski Jacek 
Published: May 2023

Abstract
Indian meal moth, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae), is a polyphagous insect pest that causes serious damage to various food crops in storage. This study aimed to investigate the life-history and demographic parameters of P. interpunctella on 5 varieties of date palm fruits (Phoenix dactylifera L.), including Dayri, Estemaran, Fersi, Halavi, and Zahedi under laboratory conditions. Data were analyzed and compared using the age–stage, 2-sex life table. Plodia interpunctella completed its development on all date varieties. The shortest and longest pre-adult periods were recorded on Zahedi (38.47 days) and Estemaran (44.65 days) varieties, respectively. The net reproductive rates (R0) were 82.51, 59.05, 63.61, 102.27, and 114.86 offspring on Dayri, Estemaran, Fersi, Halavi, and Zahedi varieties, respectively. The intrinsic rate of increase (r) were 0.098, 0.085, 0.089, 0.109, and 0.113 day−1 on Dayri, Estemaran, Fersi, Halavi, and Zahedi varieties, respectively. The female fecundity ranged from 133.4 to 259.24 eggs on Estemaran and Zahedi varieties, respectively. The highest mean generation time (T) was obtained on Estemaran (47.984 days), and the lowest value of this parameter was obtained on Zahedi (41.722 days) variety. The results indicated that Zahedi and Halavi varieties were the susceptible hosts for P. interpunctella. In contrast, the Estemaran and Fersi were the most resistant varieties against P. interpunctella, which can be used for integrated management programs to decrease the damage of this pest.
(108) Risk Factors for Reinterventions, Complications, and Infections after Inflatable Penile Prosthesis: A Propensity-Matched Study
Authors: Ebbott D , Prebay Z , Li M , Chung P 
Published: May 2023

Abstract

Introduction
Erectile dysfunction affects at least 40 million men in the United States, with inflatable penile prosthesis (IPP) used as a successful intervention in more than 25,000 men per year. Although common medical comorbidities are hypothesized to be risk factors for infections or complications, this too remains incompletely understood. Large scale, multi-institutional research may help urologists better understand the risks and rates of complications following IPP.

Objective
To characterize risk for reintervention, complications, and infections in patients with common suspected risk factors undergoing IPP placement in a multicenter global research network.

Methods
TriNetX is a research network of real-time data from 58 Healthcare Organizations globally. We queried the network for adult men with IPP implant from 2002-2022. We examined select outcomes for the general populations. We also assessed select outcomes for cohorts based on medical comorbidities that were diagnosed prior to IPP. These comorbidities included diabetes mellitus, hypertension, nicotine use, radiation, prostatectomy, urethral surgery, and organ transplant history. Propensity score matching was performed using these variables and excluding the comorbidity of interest for each cohort. International Classification of Disease Tenth Edition (ICD-10) and Current Procedural Terminology (CPT) codes were used to define cohorts and outcomes. Our primary outcome was the need for reintervention, defined here as revision, removal, or replacement at any point after implantation. Secondary outcomes included overall rates of device complication and infection. Analytics were performed using TriNetX software to calculate demographic information, odds ratios (OR), and z-test. The analysis was run on June 13, 2022.

Results
The study included 10,094 patients with an IPP from 2002 to 2022. The average index age was 62 +/− 11 and the racial demographics were 22% black and 58% white. The general population had a reintervention rate of 9.9%. The rate of complication was 18.8% with a 4.9% rate of infection. Full results are included in Table 1. No comorbidity diagnosed at the time of IPP had a significant association with higher rates of reintervention, complications, or infections.

Conclusions
Patients had higher rates of IPP complications than previously reported, but this may come from different reporting parameters used in this study. Notably, none of hypothesized comorbidities diagnosed at the time of IPP led to higher rates of reintervention, complications, or infections. Based on this data, the assessed comorbidities are not a contraindication for IPP.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Boston Scientific and Coloplast.
(125) Factors Associated with Erectile Dysfunction in Copper and Cobalt Miners: A Cross-sectional Study in the Katanga Province, DR Congo
Authors: Musa Obadia P , Pyana Kitenge J , Kayembe-Kitenge T , Carsi Kuhangana T , Kalenga Ilunga G , Billen J , Haufroid V , Mukalay A , Ris L , Banza Lubaba Nkulu C , Enzlin P , Nemery B 
Published: May 2023

Abstract

Introduction
The African Copperbelt is a site of intense artisanal and industrial mining and refining of copper and cobalt. Based on a preliminary case-control study of erectile dysfunction among mineworkers in the former Katanga province of the Democratic Republic of Congo (Musa et al. Occupational and Environmental Medicine 2020),

Objective
We further investigated possible factors associated with erectile dysfunction in copper and cobalt miners in the Katanga province.

Methods
In a cross-sectional study of 138 miners and 140 controls (bakers), we administered questionnaires face-to-face in French or Swahili to obtain socio-demographic and occupational data, and to assess male sexual function [International Index of Erectile Function (IIEF-15)] and marital relation quality [Revised Dyadic Adjustment Scale (DAS)]. We measured trace metals in blood and urine and testosterone and thyroid hormones in serum.

Results
Miners and bakers had similar median (IQR) age [35.6 y (30.6–40.0)]. Miners had significantly lower scores than bakers for IIEF-15 [66 (49–73) vs 73 (66–74)] and for the three DAS domains (Consensus; Satisfaction; Cohesion). Miners had significantly lower free testosterone (8.1 ng/dL) and thyroxin (13.45 pmol/L) than bakers (9.3 and 14.75, respectively). Factors associated with IIEF- EF scores ≤ 22 were: mining-related job (aOR 2.09, 95% CI 1.14–3.81; p=0.016), work seniority in mining (aOR 1.07, 95% CI 1.02–1.13; p=0.005) and regular use of aphrodisiacs (aOR 2.80, 95% CI 1.56–5.02; p=0.001). Mediation analysis showed that consensus mediated by 50% the relation between work seniority in mining and erectile function.

Conclusions
Compared to controls, miners had poorer sexual function and marital relation, and lower free testosterone and thyroxin. This may be due to their high exposure to trace metals (especially Pb). Erectile dysfunction is found to be increased by lower consensus in couples possibly due to longer time spent working away from home.

Disclosure
No