bluuebunny/crossref_metadata_2025_split huggingface dataset:
The moduli space of polynomial maps and their fixed-point multipliers: II. Improvement to the algorithm and monic centered polynomials
Authors: SUGIYAMA TOSHI 
Published: February 2023

AbstractWe consider the family
$\mathrm {MC}_d$
of monic centered polynomials of one complex variable with degree
$d \geq 2$
, and study the map
$\widehat {\Phi }_d:\mathrm {MC}_d\to \widetilde {\Lambda }_d \subset \mathbb {C}^d / \mathfrak {S}_d$
which maps each
$f \in \mathrm {MC}_d$
to its unordered collection of fixed-point multipliers. We give an explicit formula for counting the number of elements of each fiber
$\widehat {\Phi }_d^{-1}(\bar {\unicode{x3bb} })$
for every
$\bar {\unicode{x3bb} } \in \widetilde {\Lambda }_d$
except when the fiber
$\widehat {\Phi }_d^{-1}(\bar {\unicode{x3bb} })$
contains polynomials having multiple fixed points. This formula is not a recursive one, and is a drastic improvement of our previous result [T. Sugiyama. The moduli space of polynomial maps and their fixed-point multipliers. Adv. Math.322 (2017), 132–185] which gave a rather long algorithm with some induction processes.
Do testosterone and cortisol levels moderate aggressive responses to peer victimization in adolescents?
Authors: Calvete Esther , Orue Izaskun 
Published: February 2023

AbstractAggressive reactions to peer victimization may be tempered by hormone levels. Grounded on the dualhormone hypothesis (DHH), which proposes that testosterone (T) is associated with aggressive behavior only when cortisol (C) is low, this study assessed whether the combination of T and C moderated adolescents’ aggressive responses to peer victimization. The study involved 577 adolescents (50.4% girls, aged 12–17 years), who completed measures of online and offline victimization and perpetration of aggressive behavior in three waves over the course of one year. Moreover, they provided salivary samples to measure T and C levels. Multilevel analyses showed a three-way interaction between T, C, and victimization levels for both online and offline aggressive behaviors. In both cases, the adolescents with high T and high C or low T and low C responded with more aggressive behaviors when victimized or provoked by peers. The T/C ratio was only associated with aggressive behavior in the girls’ sample. The results are opposite to those predicted by the DHH, but they are consistent with the findings of other studies that examined aggressive behaviors as reactions to provocations. These results suggest that some combinations of T and C predict higher aggressive reactions to peer victimization.
Contextual factors of child behavioral health across developmental stages
Authors: Yoon Susan , Maguire-Jack Kathryn , Ploss Alexa , Benavidez Juan Lorenzo , Chang Yujeong 
Published: February 2023

AbstractThis study examines the relative influence of environmental contexts (family, school, neighborhood) on child behavioral health at ages 3, 5, 9, and 15 years. Path analysis was conducted on a sample of 4,898 urban children from a longitudinal dataset called the Fragile Families and Child Wellbeing Study. Child physical abuse, emotional abuse, maternal depression, substance use, neighborhood social cohesion, neighborhood poverty, school connectedness, and peer bullying had concurrent relationships with child behavior problems at one or more developmental stages. Early childhood abuse (age 3) and school age environmental contexts (age 9) had lasting effects on later behavior problems. Findings underscore the importance of both multilevel contextual factors and developmental timing in determining behavioral health outcomes in children.
Fast principal component analysis for cryo-electron microscopy images
Authors: Marshall Nicholas F. , Mickelin Oscar , Shi Yunpeng , Singer Amit 
Published: February 2023

Abstract
Principal component analysis (PCA) plays an important role in the analysis of cryo-electron microscopy (cryo-EM) images for various tasks such as classification, denoising, compression, and ab initio modeling. We introduce a fast method for estimating a compressed representation of the 2-D covariance matrix of noisy cryo-EM projection images affected by radial point spread functions that enables fast PCA computation. Our method is based on a new algorithm for expanding images in the Fourier–Bessel basis (the harmonics on the disk), which provides a convenient way to handle the effect of the contrast transfer functions. For

$ N $

images of size

$ L\times L $

, our method has time complexity

$ O\left({NL}^3+{L}^4\right) $

and space complexity

$ O\left({NL}^2+{L}^3\right) $

. In contrast to previous work, these complexities are independent of the number of different contrast transfer functions of the images. We demonstrate our approach on synthetic and experimental data and show acceleration by factors of up to two orders of magnitude.
Meridional Survey of the Central Pacific Reveals Iodide Accumulation in Equatorial Surface Waters and Benthic Sources in the Abyssal Plain
Authors: Moriyasu Rintaro , Bolster Kenneth M. , Hardisty Dalton S. , Kadko David C. , Stephens Mark P. , Moffett James W. 
Published: February 2023

AbstractThe distributions of iodate and iodide were measured along the GEOTRACES GP15 meridional transect at 152°W from the shelf of Alaska to Papeete, Tahiti. The transect included oxygenated waters near the shelf of Alaska, the full water column in the central basin in the North Pacific Basin, the upper water column spanning across seasonally mixed regimes in the north, oligotrophic regimes in the central gyre, and the equatorial upwelling. Iodide concentrations are highest in the permanently stratified tropical mixed layers, which reflect accumulation due to light‐dependent biological processes, and decline rapidly below the euphotic zone. Vertical mixing coefficients (Kz), derived from complementary 7Be data, enabled iodide oxidation rates to be estimated at two stations. Iodide half‐lives of 3–4 years show the importance of seasonal mixing processes in explaining north‐south differences in the transect, and also contribute to the decrease in iodide concentrations with depth below the mixed layer. These estimated half‐lives are consistent with a recent global iodine model. No evidence was found for significant inputs of iodine from the Alaskan continental margin, but there is a significant enrichment of iodide in bottom waters overlying deep sea sediments from the interior of the basin.
Lower Hybrid Waves in High Altitude Echoes of the Topside Equatorial Ionosphere
Authors: Derghazarian S. , Rojas E. L. , Hysell D. L. , Seyler C. E. 
Published: February 2023

AbstractWe investigate the mechanism underlying lower hybrid waves associated with high altitude echoes recently detected in the post‐sunset equatorial topside ionosphere and inner plasmasphere by the Jicamarca VHF radar. These waves are visible as prominent sidebands in the echo Doppler spectra. New experimental results and newly processed incoherent scatter radar (ISR) datasets are presented that provide clues as to the conditions in which the echoes and associated waves occur. Numerical simulations are presented which demonstrate the feasibility of an inverse energy cascade coupled with a short wavelength instability, that is, the lower hybrid drift instability, in explaining the waves. An inverse cascade is required for short wavelength lower hybrid waves to extend to the 3 m wavelengths measured by the Jicamarca radar. The simulations were able to reproduce some features of the measurements including the lower hybrid sidebands at 3 m wavelengths, asymmetry in the sidebands, and the damping effect of higher densities and lower altitudes.
Maternal preconception circulating blood biomarker mixtures, child behavioural symptom scores and the potential mediating role of neonatal brain microstructure: the S-PRESTO cohort
Authors: Huang Jian , Tan Ai Peng , Law Evelyn , Godfrey Keith M. , Qiu Anqi , Daniel Lourdes Mary , Fortier Marielle , Tan Kok Hian , Chan Jerry Kok Yen , Cameron-Smith David , Chong Yap Seng , Chan Shiao-Yng , Eriksson Johan G. , Meaney Michael J. , Huang Jonathan 
Published: February 2023

AbstractHuman brain development starts in the embryonic period. Maternal preconception nutrition and nutrient availability to the embryo may influence brain development at this critical period following conception and early cellular differentiation, thereby affecting offspring neurodevelopmental and behavioural disorder risk. However, studying this is challenging due to difficulties in characterizing preconception nutritional status and few studies have objective neurodevelopmental imaging measures in children. We investigated the associations of maternal preconception circulating blood nutrient-related biomarker mixtures (~15 weeks before conception) with child behavioural symptoms (Child Behaviour Checklist (CBCL), aged 3 years) within the Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) study. The CBCL preschool form evaluates child behaviours based on syndrome scales and Diagnostic and Statistical Manual of Mental Disorders (DSM) oriented scales. These scales consist of internalizing problems, externalizing problems, anxiety problems, pervasive developmental problems, oppositional defiant, etc. We applied data-driven clustering and a method for modelling mixtures (Bayesian kernel machine regression, BKMR) to account for complex, non-linear dependencies between 67 biomarkers. We used effect decomposition analyses to explore the potential mediating role of neonatal (week 1) brain microstructure, specifically orientation dispersion indices (ODI) of 49 cortical and subcortical grey matter regions. We found that higher levels of a nutrient cluster including thiamine, thiamine monophosphate (TMP), pyridoxal phosphate, pyridoxic acid, and pyridoxal were associated with a higher CBCL score for internalizing problems (posterior inclusion probability (PIP) = 0.768). Specifically, thiamine independently influenced CBCL (Conditional PIP = 0.775). Higher maternal preconception thiamine level was also associated with a lower right subthalamic nucleus ODI (P-value = 0.01) while a lower right subthalamic nucleus ODI was associated with higher CBCL scores for multiple domains (P-value < 0.05). One potential mechanism is the suboptimal metabolism of free thiamine to active vitamin B1, but additional follow-up and replication studies in other cohorts are needed.
Association of time spent in outdoor light and genetic risk with the incidence of depression
Authors: Lin Jing , Yang Hongxi , Zhang Yuan , Cao Zhi , Li Dun , Sun Li , Zhang Xinyu , Wang Yaogang 
Published: February 2023

AbstractDepression is the consequence of both environment and genes working together. Genetic factors increase depression risk, but it is unclear whether this association can be offset by time spent in outdoor light. The study was undertaken to investigate the optimal time spent in outdoor light for lowering the risk of depression and the joint association of time spent in outdoor light and depression genetic risk. In UK Biobank, 380,976 depression-free individuals were included in this study. Polygenic risk score (PRS) was categorized into three groups in terms of tertiles. Time spent in outdoor light on a typical day in summer or winter originated from the questionnaire survey. Depression was defined as hospital admission. The potential dose-response relationship between time spent in outdoor light and depression risk was shown by a restricted cubic spline. Data were analyzed using Cox regressions and Laplace regression. After the median follow-up of 12.6 years, 13,636 individuals suffered from depression in the end. A nonlinear (J-shaped relationship) trend was observed between time spent in outdoor light and depression risk. On average, 1.5 h/day of outdoor light was related to the minimum risk of depression. Individuals below and above this optimal time both had elevated depression risk (below, HR = 1.09, 95% CI: 1.02–1.16; above, HR = 1.13, 95% CI: 1.07–1.20), and the time to incident depression were both shortened by 0.46 years (50th percentile differences [PD] = −0.46, 95% CI: −0.78, −0.14) and 0.63 years (50th PD = −0.63, 95% CI: −0.90, −0.35) years, respectively. In a comparison of individuals with the lowest tertile of PRS and average 1.5 h/day outdoor light, the HRs and 95% CIs of depression were 1.36 (1.21–1.53) and 1.43 (1.29–1.58) in those with the highest tertile of PRS and below/above this reference value, respectively. Significant multiplicative interactions were observed between intermediate genetic risks and longer time spent in outdoor light. We found that an average of 1.5 h/day spent in outdoor light was associated with a lower depression risk whatever the degree of depression genetic predisposition. Moderate time spent in outdoor light may contribute to a decreased depression risk even among people with a higher genetic risk of depression.
Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis
Authors: Liu Bingli , Xu Jingyuan , Lu Linyao , Gao Lili , Zhu Shengjuan , Sui Yi , Cao Ting , Yang Tao 
Published: February 2023

AbstractMetformin is the biguanide of hepatic insulin sensitizer for patients with non-alcohol fatty liver disease (NAFLD). Findings regarding its efficacy in restoring blood lipids and liver histology have been contradictory. In this study, we explore metformin’s preventive effects on NAFLD in leptin-insensitive individuals. We used liver tissue, serum exosomes and isolated hepatocytes from high-fat diet (HFD)-induced Zucker diabetic fatty (ZDF) rats and leptin receptor (Lepr) knockout rats to investigate the correlation between hepatic Lepr defective and liver damage caused by metformin. Through immunostaining, RT-PCR and glucose uptake monitoring, we showed that metformin treatment activates adenosine monophosphate (AMP)-activated protein kinase (AMPK) and its downstream cytochrome C oxidase (CCO). This leads to overactivation of glucose catabolism-related genes, excessive energy repertoire consumption, and subsequent hepatocyte pyroptosis. Single-cell RNA sequencing further confirmed the hyper-activation of glucose catabolism after metformin treatment. Altogether, we showed that functional Lepr is necessary for metformin treatment to be effective, and that long-term metformin treatment might promote NAFLD progression in leptin-insensitive individuals. This provides important insight into the clinical application of metformin.
Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Authors: Boy Maxime , Bisio Valeria , Zhao Lin-Pierre , Guidez Fabien , Schell Bérénice , Lereclus Emilie , Henry Guylaine , Villemonteix Juliette , Rodrigues-Lima Fernando , Gagne Katia , Retiere Christelle , Larcher Lise , Kim Rathana , Clappier Emmanuelle , Sebert Marie , Mekinian Arsène , Fain Olivier , Caignard Anne , Espeli Marion , Balabanian Karl , Toubert Antoine , Fenaux Pierre , Ades Lionel , Dulphy Nicolas 
Published: February 2023

AbstractMyelodysplastic syndromes (MDS) are clonal hematopoietic disorders, representing high risk of progression to acute myeloid leukaemia, and frequently associated to somatic mutations, notably in the epigenetic regulator TET2. Natural Killer (NK) cells play a role in the anti-leukemic immune response via their cytolytic activity. Here we show that patients with MDS clones harbouring mutations in the TET2 gene are characterised by phenotypic defects in their circulating NK cells. Remarkably, NK cells and MDS clones from the same patient share the TET2 genotype, and the NK cells are characterised by increased methylation of genomic DNA and reduced expression of Killer Immunoglobulin-like receptors (KIR), perforin, and TNF-α. In vitro inhibition of TET2 in NK cells of healthy donors reduces their cytotoxicity, supporting its critical role in NK cell function. Conversely, NK cells from patients treated with azacytidine (#NCT02985190; https://clinicaltrials.gov/) show increased KIR and cytolytic protein expression, and IFN-γ production. Altogether, our findings show that, in addition to their oncogenic consequences in the myeloid cell subsets, TET2 mutations contribute to repressing NK-cell function in MDS patients.
Rational design of N-heterocyclic compound classes via regenerative cyclization of diamines
Authors: Fertig Robin , Leowsky-Künstler Felix , Irrgang Torsten , Kempe Rhett 
Published: February 2023

AbstractThe discovery of reactions is a central topic in chemistry and especially interesting if access to compound classes, which have not yet been synthesized, is permitted. N-Heterocyclic compounds are very important due to their numerous applications in life and material science. We introduce here a consecutive three-component reaction, classes of N-heterocyclic compounds, and the associated synthesis concept (regenerative cyclisation). Our reaction starts with a diamine, which reacts with an amino alcohol via dehydrogenation, condensation, and cyclisation to form a new pair of amines that undergoes ring closure with an aldehyde, carbonyldiimidazole, or a dehydrogenated amino alcohol. Hydrogen is liberated in the first reaction step and the dehydrogenation catalyst used is based on manganese.
Topological dual and extended relations between networks of clathrate hydrates and Frank-Kasper phases
Authors: Chen Yong , Takeya Satoshi , Sum Amadeu K. 
Published: February 2023

AbstractClathrate hydrates are a class of ordered structures that are stabilized via the delicate balance of hydrophobic interactions between water and guest molecules, of which the space-filling network of hydrogen-bonded (H-bonded) water molecules are closely related to tetrahedrally close-packed structures, known as Frank-Kasper (FK) phases. Here we report an alternative way to understand the intricate structures of clathrate hydrates, which unveils the diverse crystalline H-bonded networks that can be generated via assembly of one common building block. In addition to the intrinsic relations and pathways linking these crystals, we further illustrate the rich structural possibilities of clathrate hydrates. Given that the topological dual relations between networks of clathrate hydrates and tetrahedral close-packed structures, the descriptors presented for clathrate hydrates can be directly extended to other ordered materials for a more thorough understanding of their nucleation, phases transition, and co-existence mechanisms.
A scoping review of the impacts of COVID-19 physical distancing measures on vulnerable population groups
Authors: Li Lili , Taeihagh Araz , Tan Si Ying 
Published: February 2023

AbstractMost governments have enacted physical or social distancing measures to control COVID-19 transmission. Yet little is known about the socio-economic trade-offs of these measures, especially for vulnerable populations, who are exposed to increased risks and are susceptible to adverse health outcomes. To examine the impacts of physical distancing measures on the most vulnerable in society, this scoping review screened 39,816 records and synthesised results from 265 studies worldwide documenting the negative impacts of physical distancing on older people, children/students, low-income populations, migrant workers, people in prison, people with disabilities, sex workers, victims of domestic violence, refugees, ethnic minorities, and people from sexual and gender minorities. We show that prolonged loneliness, mental distress, unemployment, income loss, food insecurity, widened inequality and disruption of access to social support and health services were unintended consequences of physical distancing that impacted these vulnerable groups and highlight that physical distancing measures exacerbated the vulnerabilities of different vulnerable populations.
Monolayer Kagome metals AV3Sb5
Authors: Kim Sun-Woo , Oh Hanbit , Moon Eun-Gook , Kim Youngkuk 
Published: February 2023

AbstractRecently, layered kagome metals AV3Sb5 (A = K, Rb, and Cs) have emerged as a fertile platform for exploring frustrated geometry, correlations, and topology. Here, using first-principles and mean-field calculations, we demonstrate that AV3Sb5 can crystallize in a mono-layered form, revealing a range of properties that render the system unique. Most importantly, the two-dimensional monolayer preserves intrinsically different symmetries from the three-dimensional layered bulk, enforced by stoichiometry. Consequently, the van Hove singularities, logarithmic divergences of the electronic density of states, are enriched, leading to a variety of competing instabilities such as doublets of charge density waves and s- and d-wave superconductivity. We show that the competition between orders can be fine-tuned in the monolayer via electron-filling of the van Hove singularities. Thus, our results suggest the monolayer kagome metal AV3Sb5 as a promising platform for designer quantum phases.
Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings
Authors: Doherty Christopher , Byrne Charlotte V. , Baqader Sajwa , El-Chami Cecile , McBain Andrew J. , Thomason Helen A. 
Published: February 2023

AbstractMicrobial growth within a wound often manifests as biofilms, which can prevent healing and is difficult to eradicate. Novel silver dressings claim to combat wound infection, but anti-biofilm efficacy and effects on healing independent of infection are often unclear. Usingin vitroandin vivo S. aureusandP. aeruginosabiofilm models, we report the efficacy of a dressing which produces Ag1+ions; an Ag1+dressing containing ethylenediaminetetraacetic acid and benzethonium chloride (Ag1+/EDTA/BC), and a dressing containing silver oxynitrate (Ag Oxysalts) which produces Ag1+, Ag2+and Ag3+ions, against wound biofilms, and their effects on healing. Ag1+dressings had minimal effect onin vitroand murine (C57BL/6j) wound biofilms. In contrast, Ag Oxysalts and Ag1+/EDTA/BC dressings significantly reduced viable bacteria withinin vitrobiofilms and demonstrated a visible reduction in bacteria and EPS components within murine wound biofilms. The dressings had different effects on the healing of biofilm-infected and uninfected wounds, with Ag Oxysalts dressings having a greater beneficial effect on re-epithelialisation, wound size and inflammation than the control treatment and the other silver dressings. The different physicochemical properties of the silver dressings result in varied effects on wound biofilms and healing which should be considered when selecting dressings to treat biofilm-infected wounds.
Effects of microplastics and surfactants on surface roughness of water waves
Authors: Sun Yukun , Bakker Thomas , Ruf Christopher , Pan Yulin 
Published: February 2023

AbstractWe study the flow physics underlying the recently developed remote sensing capability of detecting oceanic microplastics, which is based on the measurable surface roughness reduction induced by the presence of microplastics on the ocean surface. In particular, we are interested in whether this roughness reduction is caused by the microplastics as floating particles, or by surfactants which follow similar transport paths as microplastics. For this purpose, we experimentally test the effects of floating particles and surfactants on surface roughness, quantified by the mean square slope (MSS), with waves generated by a mechanical wave maker or by wind. For microplastics, we find that their effect on MSS critically depends on the surface area fraction of coverage. The damping by particles is observed only for fractions above O (5–10%), much higher than the realistic ocean condition. For surfactants, their damping effects on both mechanically generated waves and wind waves are quantified, which are shown to be much more significant than that by microplastics. Several new mechanisms/relations for roughness damping by surfactants are also identified. The implications of these experimental results to remote sensing are discussed.