bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereotactic radiosurgery for distant punctate recurrent IDH-wild type glioblastoma: a single institution experience
Authors: Park David J. , Yoo Kelly H. , Marianayagam Neelan J. , Yener Ulas , Chuang Cynthia , Pollom Erqi L. , Soltys Scott G. , Chang Steven D. , Meola Antonio 
Published: April 2023

Abstract
Background
Glioblastoma (GBM) is a malignant brain tumor that is common and fatal among adults. The standard treatment for GBM involves chemoradiation per Stupp's protocol and additional chemotherapy regimens. However, Stereotactic Radiosurgery (SRS) is frequently used as a single-fraction treatment for punctate recurrent GBM to the contrast-enhancing target on T1 MRI scan without prior assessment of its efficacy.
Objective
This study aimed to evaluate the safety and efficacy of SRS for patients with distant punctate recurrent IDH-wild type (wt) GBM.
Method
This retrospective study analyzed the clinical and radiological outcomes of patients with distant punctate recurrent IDH-wt GBM who underwent CyberKnife SRS at the institute between 2013 and 2022.
Results
A total of five patients (median age of 53 years) with nine lesions were treated with a median margin dose of 20 Gy. The results indicated that SRS, delivered as a single fraction, did not provide good local tumor control. The 3-, 6-, and 12-month local tumor control rates were 77.8%, 66.7%, and 26.7%, respectively. Median progression-free survival (PFS) was 7 months, and median overall survival (OS) was 35 months. Interestingly, the only lesion that did not show radiological progression was not associated with the T2-FLAIR hyperintense area surrounding the original tumor in the MRI. None of the patients presented adverse radiation effects.
Conclusion
SRS as a treatment for distant punctate recurrent IDH-wt GBM may lead to limited benefit in terms of local tumor control. Expanding the radiosurgical field to consider the T2-FLAIR hyperintense area may be necessary to improve local tumor control and survival outcomes. Further research is needed to improve SRS outcomes by developing new contouring and dosing strategies.
TSLP reduced neuroinflammation by blocking the activation of microglia in the JAK2/STAT5 pathway
Authors: Zhou Qiao , Cui Nanxue , Zhang Shihai , Zhou Miaomiao , Xu Younian 
Published: April 2023

Abstract
The thymic stromal lymphopoietin (TSLP) in the central nervous system is highly expressed in response to inflammation but the function of TSLP is still unclear. Using the LPS-stimulated microglia model, we measured oxidative stress, microglial activation markers, and inflammatory indexes to examine the direct impact of TSLP on LPS-stimulated microglia activation as well as the underlying mechanism. The results demonstrated that TSLP treatment decreased LPS-induced oxidative stress, inflammation, and the expression of M1-type markers in microglia by increasing TSLP receptor expression. The results also showed that TSLP treatment could control the differentiation of microglia toward M2 type by preventing the activation of microglia in the JAK2/STAT5 pathway with the presence of LPS, even though TSLP may directly promote the expression of pro-inflammatory cytokines without the presence of LPS. These findings support the hypothesis that TSLP reduces neuroinflammation and blocks the JAK2/STAT5 pathway induced by LPS, revealing the regulatory role of TSLP in the central nervous system and presenting a novel strategy for the control of the inflammatory response in the central nervous system.
Multifactor fuzzy time series forecasting modeling: an application in atmosphere pollutant concentration prediction
Authors: Zhang Xue-yang , Wang Ya-nan , Xiao Yu-jie , Wang Xiao-kang , Xiao Fei 
Published: April 2023

Abstract
Effective prediction of atmosphere pollutant concentration is an essential and vital activity, for the benefit of conducting preventive measures to protect public health in advance. This significant activity has attracted extensive researches, of which the majority focus on addressing the prediction of specific value in the time series. Considering the imprecision of point prediction caused by the violent fluctuation in pollutant concentration, and the fact that the precise value is not as good as the degree of pollution adaptable for human perception and decision-making, a novel multifactor fuzzy time series (FTS) forecasting model for air quality level forecast is proposed in this paper. In this model, the fuzzy derivation mechanism of conventional FTS model is implemented by support vector machine (SVM), which enhances the systematization of the FTS model and overcomes its disability in simultaneously considering other influencing factors. Besides, to further improve the accuracy of our model, random forest (RF) and fuzzy information granulation (FIG) are employed to construct the optimal combination of influential variables. Finally, to verify the effectiveness of the proposed model, a case study and three kinds of contrastive models are performed, so as to further highlight the superior performance of the proposed model.
Study of structural, electronic, and magnetic properties of NdFeSi compound.
Authors: Kumar Aman , Kumar Anuj 
Published: April 2023

Abstract
The electronic and magnetic characteristics of the intermetallic substance NdFeSi have been examined in this paper. These characteristics were investigated, A theoretical method is the full potential linearized augmented plane wave plus local orbital (FP-LAPW + lo) method based on density functional theory (DFT). We have calculated that the structural properties in terms of the lattice constant are in nearly same as with the experimental values. Similarly, we have calculated electronic properties of our compound such as band diagrams and as well as total density of state (TDOS) and partial density of state (PDOS). these properties show that our compound has a metallic nature, and this nature is due to the Nd-f state. Magnetic properties in terms of magnetic moments demonstrate that the Nd-f state is responsible for the ferromagnetic nature. All computed parameters were found to closely match experimental as well as theoretical values.
Gut microbiota response to sucralose or rebaudioside A in rats under two dietary conditions
Authors: Ramos-García Meztli , Genis-Mendoza Alma Delia , García-Vázquez Carlos , Martínez-Magaña José Jaime , Olvera-Hernández Viridiana , Martínez-López Mirian Carolina , Díaz-Zagoya Juan Cuauhtémoc , Alvarez-Villagomez Carina Shianya , Juárez-Rojop Isela Esther , Nicolini Humberto , Ble-Castillo Jorge Luis 
Published: April 2023

Abstract
Research reported that sucralose induces metabolic derangements via gut microbiota modulation. However, rebaudioside A (reb A) exposure on gut microbiota has barely been evaluated. The aim of this study was to examine the gut microbiota response to sucralose or reb A in rats under two dietary conditions. Male Wistar rats (150–200 g) on normal diet (ND) or high-fat diet (HFD) were randomized to receive sucralose (SCL), reb A (REB), glucose (GLU, control), or sucrose (SUC). After eight weeks, fecal samples were analyzed by 16S ribosomal RNA gene sequencing. The diversity and the structure of the gut microbiota were not modified by NNS. In ND rats, SCL decreased phylum Firmicutes and increased Bacteroidetes and its genus Bacteroidia. At class level, in HFD rats, REB reduced Bacilli proportions. The genus Romboutsia was reduced with SCL and REB along ND. Lactobacillus increased with SCL and reduced with REB in HFD. After comparative analyses between the two types of diets, we observed that only HFD in combination with SCL increased Bacilli and diminished Bacteroidiaabundances relative to ND. Exposure to NNS, at equivalent doses to the ADI, slightly induce modifications on gut microbiota in ND and HFD feeding rats, and the effects were more pronounced with sucralose ingestion combined with the HFD regimen. Further studies are needed to examine the potential mechanisms involved.
Defining transformation events for gene drive in species complexes
Authors: Connolly John B. 
Published: April 2023

Abstract

Engineered gene drives (EGDs) that allow the super-Mendelian inheritance of genetic traits could one day be used to reduce the vectorial capacity ofAnophelesspecies that transmit human malaria in Africa. ManyAnophelesspecies belong to complexes of closely related sibling species that can produce fertile interspecific hybrid females. In cases where the genomic target locus of the EGD is conserved amongst sibling species from the same complex as the released target species, it would therefore be plausible that the EGD could be vertically transmitted from the target species to sibling species by interspecific mating. To differentiate genetically modified organisms, the term ‘transformation event’ is used, based on the specific genomic location of the transgenic construct, as a result of random genomic integration. In contrast, an EGD is generated via its precise and reproducible insertion in its specific genomic target locus. These considerations pose two key questions for the use of EGD in species complexes: (i) what does the definition of “transformation event” mean in the context of vertical gene drive transfer of the EGD to sibling species in species complexes and (ii) doesde novotransformation of an EGD into a sibling species constitute the same transformation event as introgression by backcrossing into a sibling species of an EGD that had been originally transformed in the target species? While definitions of the term transformation event that have been provided by national and intergovernmental organisations are somewhat ambiguous, they do provide scope for broad interpretation of vertical gene drive transfer of a specific EGD to different sibling species of the target species as the same transformation event. There also appears to be some consensus that definitions of transformation event support the notion thatde novotransformations of an EGD in sibling species constitute the same transformation events as introgression by backcrossing into sibling species of an EGD that had been originally inserted in the target species.
Molecular Docking, Acute Toxicity and Antibacterial Study of Debilon and Phorbasterone-B Extracted from Rhodophyta
Authors: Salman Saad , Shah Fahad Hassan , Shah Mehwish , Kim Song Ja 
Published: April 2023

Introduction:
Natural compounds obtained from marine algae, especially Rhodophyta are now
being investigated for various biological activities. However, the antimicrobial activity and toxicity profile
of compounds present in these algae isunderexplored.

Objective:
This study procured two compounds, Debilon and Phorbasterone-B, from Rhodophyta to analyze
their in silico and in vitro potential against pathogenic bacterial strains and their acute toxicity.

Methods:
Debilon and Phorbasterone-B were extracted from Rhodophyta by a previously reported method
and were further subsequently exploited computationally for their physicochemical properties, prediction
of biological activity and molecular docking against bacterial proteins, toxicity, and experimentally
for antibacterial potential against pathogenic strains of Vibrio cholera, Salmonella typhi, Escherichia coli,
Enterococcus faecalis, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa.

Results:
Docking studies proved that these molecules possess a chemical affinity for the bacterial proteins
and can inhibit the growth of these microorganisms, as confirmed by antibacterial assay. Whereas the
prediction analysis and toxicity studies showed that the friendliness of these molecules to the human body
is enormous.

Conclusion:
From this study, it has been proved that DN and PB are perfect candidates for inhibiting
these bacterial strains.
Assessment of Wound Healing Potential of Simvastatin Emulgel in Rat
Excision Wound Model
Authors: Gupta Surbhi , Anand Anubhav , Gupta Ramesh Kumar 
Published: April 2023

Background:
Microorganisms can infect wounds and disrupt healing by causing inflammation
and tissue injury

Objective:
Simvastatin (SIM) is reported to have antibacterial activity; therefore, this research is designed
to evaluate the efficacy of simvastatin emulgel in wound healing.

Methods:
The simvastatin emulgel was assessed for physical appearance, rheological behaviour, spreadability,
pH, ex vivo drug release and in vivo activity. The wound-healing activity was assessed by percent
wound contraction, hydroxyproline estimation and histopathological evidence in wound-induced albino
rats.

Results:
The simvastatin emulgel exhibited viscosity and spreadability of 6875 ± 531.21 mPa.s and 10.15
± 0.31 g.cm/sec, respectively. The simvastatin emulgel exhibited wound contraction in wound healing
studies compared to the reference product (p < 0.05). This activity was statistically significant (p < 0.05)
in comparison to the control. The hydroxyproline content supported the wound-healing promoting effect
of simvastatin emulgel, and marked improvements in the skin histological architecture were seen in the
histopathological study.

Conclusion:
The study manifested the promising potential of simvastatin emulgel in speeding the healing
of rat wounds with epithelization. Therefore, the designed simvastatin emulgel can be used as an option
for the conventional topical dosage form.
Adaptation of ACTivate Your Wellbeing, a Digital Health and Well-being Program for Young Persons: Co-design Approach
Authors: Brown Menna , Lord Emily , John Ann 
Published: April 2023

Background
ACTivate your wellbeing is a digital health and well-being program designed to support and encourage positive lifestyle behavior change. The website includes 5 lifestyle behavior change modules and a 12-week well-being intervention based on acceptance and commitment therapy. It was timely to adapt the resource for a new audience in the wake of the COVID-19 pandemic. Young persons’ mental health needs have increased substantially, and lifestyle behaviors play a critical role in both mental and physical health statuses.

Objective
This study aimed to adapt an existing health and well-being website for use by young persons aged 16 to 24 years.

Methods
A 3-staged participatory, co-design approach was adopted. The participants reviewed the existing program and provided feedback (stage 1) before cocreating new content (stage 2). Finally, the updated program underwent formative evaluation (stage 3). Two groups were created: one had access for 3 weeks and the other could self-select their study duration. The options were 3 weeks, 60 days, or 90 days. Outcome measures were the Warwick and Edinburgh Mental Well-being Scale, 4-item Patient Health Questionnaire, and Acceptance and Action Questionnaire version 2.

Results
Stage 1 identified that the website was appealing to the new audience (19/24, 79%), and the 3 web-based focus group discussions explored data from the written review in more depth to identify and clarify the main areas for update and adaptation. Overall, 3 themes were developed, and the data informed the creation of 6 tasks for use in 5 web-based co-design workshops. Stage 2 led to the cocreation of 36 outputs, including a new name, new content, scenarios, images, and a new user dashboard, which included streaks and an updated color scheme. After the website update program was completed, 40 participants registered to use the website for formative evaluation (stage 3). Data analysis revealed differences in engagement, completion, and mean well-being after intervention between the 2 groups. The completion rate was 68% in the 3-week duration group, and well-being scores improved after intervention.

Conclusions
Young persons engaged actively with the participatory design process. The participants discussed the updates they desired during the web-based discussions, which worked well via Zoom (Zoom Video Communications Inc) when small groups were used. The participants easily cocreated new content during the web-based co-design workshops. The web-based format enabled a range of participants to take part, share their ideas, search for images, and design digital content creatively together. The Zoom software enabled screen sharing and collaborative whiteboard use, which helped the cocreation process. The formative evaluation suggested that younger users who engage more with the website for a shorter duration may benefit more.
Appropriate Image Selection With Virtual Reality in Vestibular Rehabilitation: Cross-sectional Study
Authors: Ersin Kerem , Gürlek Emre , Güler Hakan , Kalaycık Ertugay Çiğdem , Şerbetçioğlu Mustafa Bülent 
Published: April 2023

Background
While vestibular rehabilitation with virtual reality (VR) is becoming more popular every day, the disadvantages of this method are not yet clear.

Objective
The aim of this study is to examine the effect of the image to be used in vestibular rehabilitation with VR on the systems that provide body posture.

Methods
The study was carried out with 36 participants (18 women and 18 men) aged 18 to 30 years. To assess balance control components separately, a sensory organization test was administered to the participants in the presence of stressful and relaxing environment images with VR technology. The State-Trait Anxiety Inventory survey was also used to measure the stress values in the created environments.

Results
The State-Trait Anxiety Inventory survey revealed that while stressful videos significantly increased stress, relaxing videos reduced stress. Among measurements obtained in the presence of VR, significant decreases were observed mostly in the visual system data. A significant increase in vestibular system data (P=.01) was observed with a decrease in visual system data (P<.001) when the relaxing image was presented. Additionally, there was a significant difference in the somatosensory (P=.001), composite (P=.002), and visual system (P<.001) data in the presence of stressful videos.

Conclusions
Although the use of a VR system for vestibular rehabilitation is relatively new, no extant studies have examined how the image type used in VR can affect the integration of visual system data. Therefore, this study is unique in terms of showing the effects of the stress created by the change in the type of the image used in VR. When VR technology is used for therapeutic vestibular rehabilitation for patients whose balance disorder is due to the vestibular system, stress-free videos should be used. However, the use of stressful videos in VR technology will be beneficial in the rehabilitation of those with balance disorders due to the somatosensory system.
Consumers’ Needs for Laboratory Results Portals: Questionnaire Study
Authors: Monkman Helen , Griffith Janessa , MacDonald Leah , Lesselroth Blake 
Published: April 2023

Background
Over the last decade, there has been an increase in the number of health care consumers (ie, patients, citizens, and laypeople) with access to their laboratory results through portals. However, many portals are not designed with the consumer in mind, which can limit communication effectiveness and consumer empowerment.

Objective
We aimed to study design facilitators and barriers affecting consumer use of a laboratory results portal. We sought to identify modifiable design attributes to inform future interface specifications and improve patient safety.

Methods
A web-based questionnaire with open- and closed-ended items was distributed to consumers in British Columbia, Canada. Open-ended items with affinity diagramming and closed-ended questions with descriptive statistics were analyzed.

Results
Participants (N=30) preferred reviewing their laboratory results through portals rather than waiting to see their provider. However, respondents were critical of the interface design (ie, interface usability, information completeness, and display clarity). Scores suggest there are display issues impacting communication that require urgent attention.

Conclusions
There are modifiable usability, content, and display issues associated with laboratory results portals that, if addressed, could arguably improve communication effectiveness, patient empowerment, and health care safety.
Acción pública en contexto de crisis: Los fallos del estado en contexto covid–19
Authors: Yévenes Subiabre Ariel 
Published: April 2023

En el presente ensayo se exploran ámbitos relacionados a las condiciones que han de darse para que las sociedades se conduzcan hacia decisiones que propicien asignaciones eficientes de recursos y alcanzar un escenario de bienestar, contextualizando estos análisis al escenario señalado de la Crisis COVID-19 en Chile.
Así, se analizan coyunturas que revelan la existencia de fallos de Estado que, analizados en contexto de la simultanea existencia de fallos de mercado, actúan como limitantes del bienestar social, proponiendo para ello instancias de articulación público privada para la construcción colectiva del bienestar social, en equilibrio público y privado, como también la importancia de fortalecer la descentralización, para propiciar la flexibilidad, agilidad y pertinencia de las políticas en el nivel territorial local.
Actividad económica y empleo post pandemia
Authors: Méndez Briones Luis 
Published: April 2023

Superada la fase más aguda de la pandemia, los países a lo largo del mundo están preocupados en cómo superar los daños económicos y las consecuencias en el empleo. La crisis nos dejó tres males que en conjunto son difíciles de superar, inflación, recesión y caídas en el empleo.
Ante el escenario descrito las economías van tratando de reactivarse, Estados Unidos y la zona europea con mejor éxito, China con mayores dificultades y aún con brotes de Covid no controlados. En América Latina con luces y sombras. Al respecto CEPAL pronostica a Chile como una de las economías de menor crecimiento para el año 2023.En tal escenario cabe la preguntarse cómo afectará el descenso de la actividad económica en el mercado de trabajo en los meses venideros? ¿Es posible hacer una estimación de su impacto en las tasas de ocupación y desempleo?
Propensity score adjustment of a treatment effect with missing data in psychiatric health services research
Authors: Mayer Benjamin , Puschner Bernd 
Published: April 2023

Background: Missing values are a common problem for data analyses in observational studies, which are frequently applied in health services research. This paper examines the usefulness of different approaches to tackle the problem of incomplete observational data, focusing whether the Multiple Imputation (MI) strategy yields adequate estimates when applied to a complex analysis framework.
Methods: Based on observational study data originally comparing three forms of psychotherapy, a simulation study with different missing data scenarios was conducted. The considered analysis model comprised a propensity score-adjusted treatment effect estimation. Missing values were handled by complete case analysis, different MI approaches, as well as mean and regression imputation.
Results: All point estimators of the applied methods lay within the 95% confidence interval of the treatment effect derived from the complete simulation data set. Highest deviation was observed for complete case analysis. A distinct superiority of MI methods could not be demonstrated.
Conclusion: Since there was no clear benefit of one method to deal with missing values over another, health services researchers faced with incomplete observational data are well-advised to apply different imputation methods and compare the results in order to get an impression of their sensitivity.