bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disordered Au Nanoclusters for Efficient Ammonia Electrosynthesis
Authors: Peng Xianyun , Zhang Rui , Mi Yuying , Wang Hsiao‐Tsu , Huang Yu‐Cheng , Han Lili , Head Ashley R. , Pao Chih‐Wen , Liu Xijun , Dong Chung‐Li , Liu Qian , Zhang Shusheng , Pong Way‐Faung , Luo Jun , Xin Huolin L. 
Published: January 2023

AbstractThe electrochemical nitrogen (N2) reduction reaction (N2RR) under mild conditions is a promising and environmentally friendly alternative to the traditional Haber‐Bosch process with high energy consumption and greenhouse emission for the synthesis of ammonia (NH3), but high‐yielding production is rendered challenging by the strong nonpolar N≡N bond in N2 molecules, which hinders their dissociation or activation. In this study, disordered Au nanoclusters anchored on two‐dimensional ultrathin Ti3C2Tx MXene nanosheets are explored as highly active and selective electrocatalysts for efficient N2‐to‐NH3 conversion, exhibiting exceptional activity with an NH3 yield rate of 88.3±1.7 μg h−1 mgcat.−1 and a faradaic efficiency of 9.3±0.4 %. A combination of in situ near‐ambient pressure X‐ray photoelectron spectroscopy and operando X‐ray absorption fine structure spectroscopy is employed to unveil the uniqueness of this catalyst for N2RR. The disordered structure is found to serve as the active site for N2 chemisorption and activation during the N2RR process.
Thyroblastoma: A DICER1‐associated embryonal neoplasm and fine needle aspiration diagnostic criteria
Authors: Jitpasutham Tikamporn , Faquin William C. , Torous Vanda F. , Nosé Vania 
Published: January 2023

AbstractThyroblastoma is a rare, aggressive embryonal thyroid neoplasm associated with DICER1 mutation. It usually presents as a rapidly growing thyroid mass diffusely infiltrating the thyroid lobes and extending into perithyroidal tissue. Most thyroblastomas were initially diagnosed as malignant teratoma or carcinosarcoma. The cytologic features of thyroblastoma have not been well documented. Here, we present the cytological findings of a case of thyroblastoma in a 19‐year‐old female with a dominant solid left thyroid nodule. A fine needle aspiration biopsy of the mass revealed a highly cellular aspirate composed of crowded, atypical, high nuclear to cytoplasmic ratio epithelial cells, arranged in a variety of architectural patterns including rosette‐like microfollicular, solid, and morular. In addition, the background contains a minor population of atypical mesenchymal cells. The cytologic differential diagnosis of thyroblastoma includes primary thyroid neoplasms such as adenomatous nodule, follicular adenoma, follicular carcinoma, and poorly differentiated thyroid carcinoma as well as metastatic carcinoma.
Effects of intermittently scanned continuous glucose monitoring in adult type 1 diabetes patients with suboptimal glycaemic control: A multi‐centre randomized controlled trial
Authors: Yan Jinhua , Zhou Yongwen , Zheng Xueying , Zheng Mao , Lu Jing , Luo Sihui , Yang Daizhi , Deng Hongrong , Xu Wen , Bi Yan , Bao Wei , Weng Jianping 
Published: January 2023

AbstractAimsTo investigate whether intermittently scanned continuous glucose monitoring without alarms (intermittently scanned CGM (isCGM)) improves glycaemic control over capillary blood glucose monitoring (BGM) among adult type 1 diabetes mellitus (T1DM) patients with suboptimal control.Materials and MethodsAdults with T1DM and HbA1c between 7% and 10% were 1:1 randomized to use isCGM or BGM for 24 weeks. The primary outcome was the change in HbA1c levels after intervention. The secondary outcomes were the changes in sensor‐derived metrics.ResultsA total of 104 adults with T1DM (34.2 ± 12.2 years; M/F, 38/66) were randomized to the isCGM group (n = 54) and the BGM group (n = 50). After 24 weeks, HbA1c significantly decreased in the isCGM group (8.1 ± 0.7% to 7.5 ± 1.0%) and the BGM group (8.0 ± 0.8% to 7.7 ± 1.0%) with between‐group differences of 0.3% (95% coefficient intervals, 0.0%–0.6%; P = 0.04). The percentage of HbA1c reduction over 1.0% and 1.5% was significantly higher in the isCGM group with adjusted odds ratios of 2.5 (95% CI: 1.1–5.5; P = 0.03) and 3.2 (95% CI: 1.1–9.0; P = 0.03). Mean time‐in‐range 70–180 mg/dl (TIR) in the isCGM group significantly increased (from 58.5 ± 13.0% to 63.0 ± 12.6%), whereas mean TIR was similar in the BGM group (from 58.0 ± 14.6% to 57.5 ± 14.5%). Time spent in hyperglycemia reduced more in the isCGM group and time spent in hypoglycemia did not change significantly in both groups.ConclusionsAmong adult T1DM patients with suboptimal glycaemic control, compared with BGM, isCGM use resulted in a statistically significant improvement in glycaemic control after 24‐week intervention.Trial RegistrationClinicaltrials.gov Identifier (NCT03522870)
Synthesis of 1,3‐cis‐Fused Tricyclic System through Regio‐ and Stereoselective Epoxidation and Ring‐Rearrangement Metathesis: Access To Basic Core of Presilphiperfolanols
Authors: Kotha Sambasivarao , Reddy Keesari Ramakrishna , Ravikumar Ongolu 
Published: January 2023

AbstractHere, we report a new synthetic approach to a highly strained 1,3‐fused cis‐cis‐cis‐5/5/6 tricyclic system that appeared among the presilphiperfolanol analogues. The cis‐fusion of six‐membered ring to a diquinane moiety is accomplished by substrate‐controlled regio‐ and stereoselective epoxidation, and ring‐rearrangement metathesis (RRM) sequence. In this regard, both early‐, and late‐stage epoxidation and RRM reactions were studied. The target compound, cis‐cis‐cis‐5/5/6 tricyclic ketone with an α,β‐oxirane ring can serve as a key building block to produce various presilphiperfolanol analogues. The cis‐cis‐cis‐5/5/6‐tricyclic‐α,β‐epoxyketone can also act as masked enone and therefore useful for various chemical transformations in organic synthesis. The short synthetic sequence disclosed here may be useful to design various biologically important molecules. The newly reported molecules are well‐characterized by NMR, HRMS, and IR spectral data.
Incidence of trigeminal neuralgia: A population‐based study in Central Sweden
Authors: Svedung Wettervik Teodor , Snel Daniel , Kristiansson Per , Ericson Hans , Abu Hamdeh Sami 
Published: January 2023

AbstractBackgroundThe primary aim of this observational study was to determine the incidence of trigeminal neuralgia (TN) in a county in central Sweden. The secondary aim was to investigate TN characteristics including the affected side and nerve branches.MethodsPatients that received the ICD‐10 diagnostic codes TN (G50.0), atypical facial pain (G50.1) and other/unspecified disorder of the trigeminal nerve (G50.8 and G50.9) in Uppsala County, between 2009 and 2017, were eligible for inclusion. Case ascertainment was conducted by the authors by review of the medical records.ResultsThe incidence of TN was estimated to be 5.5 (95% confidence interval 4.7–6.4) per 100,000 person‐years. The incidence increased with age, from 0.1 in 0‐ to 19‐year‐olds to 23.1 per 100,000 person‐years in 80+‐year‐olds. Females exhibited a higher incidence at 7.3 than males at 3.7 per 100,000 person‐years. Most of the trigeminal neuralgia cases were diagnosed in the Neurology department (47%). Trigeminal neuralgia was most frequently right sided (59%) and limited to one cranial nerve V‐branch, of which V2 was the most common.ConclusionsTrigeminal neuralgia incidence was estimated to be 5.5 per 100,000 person‐years. The incidence was higher for females and increased with older age.SignificanceThere is limited knowledge about the true incidence of trigeminal neuralgia. This manuscript provides an estimate of 5.5 cases per 100,000 person‐years, by using a thorough case ascertainment methodology.
Prediction model of regional economic development potential based on data mining technology
Authors: Yang Jiayan 
Published: January 2023

AbstractDue to the differences between regions, the regional economy is also affected by the development of the real economy and the environment in a specific region. Thus, it is necessary to predict the development potential of the regional economy to ensure the smooth operation of the economy. The continuous upgrading of technology enables the country to grasp the development trend of the regional economy more accurately than ever before. However, the existing prediction techniques still have large errors. Therefore, this paper constructed a prediction model based on data mining technology to predict the development potential of the regional economy to enhance the accuracy of predictive models. The experiments showed that the prediction accuracy of the prediction model constructed in this paper could reach 96.78%, which could provide an accurate reference for the development of the regional economy to ensure the stable development of the regional economy, and has important application value.
High‐entropy stabilized oxides derived via a low‐temperature template route for high‐performance lithium‐sulfur batteries
Authors: Raza Hassan , Cheng Junye , Lin Cong , Majumder Soumyadip , Zheng Guangping , Chen Guohua 
Published: January 2023

AbstractIt is a long‐standing issue that the sluggish polysulfide conversion and adverse shuttling effects impede the development of lithium‐sulfur (Li‐S) batteries with high energy density and cycling stability, which necessitate the exploration of new electrocatalysts to facilitate the practical applications of Li‐S batteries. Herein, a single‐phase high‐entropy stabilized oxide (Ni0.2Co0.2Cu0.2Mg0.2Zn0.2)O (HEO850) is successfully prepared through a novel low‐temperature annealing strategy from a self‐sacrificing metal–organic frameworks (MOFs) template and then integrated into the sulfur host, where it functions as both the catalytic converter and chemical inhibitor towards the shuttle species. Furthermore, the synergistic contribution of randomly dispersed metal elements and the exposure of affluent active sites enable the chemical encapsulation of soluble polysulfides and accelerate conversion kinetics. The HEO850/S/KB cathode (KB: ketjen black; sulfur content: 70 wt.%) delivers a substantially higher initial specific discharge capacity of ~1244 mAh g−1 in comparison to MEO/S/KB (MEO: medium entropy oxide; ~980 mAh g−1), LEO/S/KB (LEO: low entropy oxide; ~908 mAh g−1), and routine S/KB cathodes (~966 mAh g−1), which is well retained at ~784 mAh g−1 after 800 cycles at 0.5 C with a low capacity decay rate of ~0.043% per cycle. Moreover, when the HEO850/S/KB cathode is processed with a high areal sulfur loading (~4.4 mg cm−2), the resulting Li‐S battery also performs well, with a high initial specific capacity of ~1044 mAh g−1 at 0.1 C and 85% capacity retention after 100 cycles. This study highlights the potential application of HEOs in enhancing the performance of Li‐S batteries and provides a novel strategy in synthesizing the HEOs at a relatively low annealing temperature for various energy conversion and storage applications.image
Eurocode‐8‐conforming seismic design and behaviour factor of high‐post‐yield stiffness concentrically‐braced steel frames
Authors: Hassan Mahmoud , Vasdravellis George , Vamvatsikos Dimitrios 
Published: January 2023

AbstractA seismic‐resistant steel frame with energy‐dissipating, chevron‐type braces is proposed. The braces are equipped with replaceable hourglass‐shaped pins made of duplex stainless steel. Under design seismic loading, energy is dissipated through inelastic deformations confined in the replaceable pins while the other members remain essentially elastic. As a result, the frame exhibits high post‐yield stiffness due to the inherent properties of the stainless‐steel pins. A Eurocode‐8‐based design methodology is adopted for the frame and assessed following the Eurocode‐8‐compatible INNOSEIS approach. Specifically, the overstrength factor is evaluated through nonlinear pushover analysis while the behaviour factor is assessed through incremental dynamic analysis considering high and medium seismicity site‐specific ground motion suites. The determined behaviour factor satisfies the global collapse prevention and life safety objectives while also keeping the maximum residual inter‐storey drifts below 1/300 to permit an easy substitution of the damaged pins after the design level earthquake.
Processing methods for conductive polymer composite bipolar plates: Effect on plate quality and performance
Authors: Alo Oluwaseun Ayotunde , Otunniyi Iyiola Olatunji , Sadiku Emmanuel Rotimi 
Published: January 2023

AbstractConductive polymer composites (CPCs) have been identified as viable replacements for graphite and metals for polymer electrolyte membrane fuel cell (PEMFC) bipolar plates (BPs). One important factor, apart from composite formulation, that affects the quality and properties of CPC BPs is the processing route. Therefore, understanding the possible processing methods for different matrix–filler combinations and their effects on the quality and properties of the plates can help in controlling and improving the final performance of BPs. This paper reviews the blending and molding techniques for CPC BPs, with a focus on relationship between formulation and processing method. The effects of processing route and conditions on microstructural features of CPC BPs, which affect the performance of the plates are also discussed. Finally, directions for further studies with potential to advance the development of quality and high‐performance CPC BPs are highlighted. Identified key areas for further research include control of filler orientation to improve through‐plane conductivity, correlation between processing parameters and dimensional accuracy of molded plates, and additive manufacturing of composite BPs.
Identification of a novel gene signature for neuroblastoma differentiation using a Boolean implication network
Authors: Zage Peter E. , Huo Yuchen , Subramonian Divya , Le Clorennec Christophe , Ghosh Pradipta , Sahoo Debashis 
Published: January 2023

AbstractAlthough induction of differentiation represents an effective strategy for neuroblastoma treatment, the mechanisms underlying neuroblastoma differentiation are poorly understood. We generated a computational model of neuroblastoma differentiation consisting of interconnected gene clusters identified based on symmetric and asymmetric gene expression relationships. We identified a differentiation signature consisting of series of gene clusters comprised of 1251 independent genes that predicted neuroblastoma differentiation in independent datasets and in neuroblastoma cell lines treated with agents known to induce differentiation. This differentiation signature was associated with patient outcomes in multiple independent patient cohorts and validated the role of MYCN expression as a marker of neuroblastoma differentiation. Our results further identified novel genes associated with MYCN via asymmetric Boolean implication relationships that would not have been identified using symmetric computational approaches and that were associated with both neuroblastoma differentiation and patient outcomes. Our differentiation signature included a cluster of genes involved in intracellular signaling and growth factor receptor trafficking pathways that is strongly associated with neuroblastoma differentiation, and we validated the associations of UBE4B, a gene within this cluster, with neuroblastoma cell and tumor differentiation. Our findings demonstrate that Boolean network analyses of symmetric and asymmetric gene expression relationships can identify novel genes and pathways relevant for neuroblastoma tumor differentiation that could represent potential therapeutic targets.
Maximizing Use of Pelagic Capture Fisheries for Global Protein Supply: Potential and Caveats Associated with Fish and Co‐Product Conversion into Value‐Add Ingredients
Authors: Hayes Maria 
Published: January 2023

AbstractGlobally, capture fisheries contribute significantly to protein supply and the food security of a third of the world's population. Although capture fisheries production has not significantly increased in tonnes landed per annum during the last two decades (since 1990), it still produced a greater tonnage of protein than aquaculture in 2018. Policy in the European Union and other locations favors production of fish through aquaculture to preserve existing fish stocks and prevent extinction of species from overfishing. However, aquaculture production of fish in order to feed the growing global population would need to increase from 82 087 kT in 2018 to 129 000 kT by 2050. The Food and Agriculture Organization states that global production of aquatic animals was 178 million tonnes in 2020. Capture fisheries contributed 90 million tonnes (51%) of this. For capture fisheries to be a sustainable practice in alignment with UN sustainability goals, ocean conservation measures must be followed and processing of capture fisheries may need to adapt food‐processing strategies already used extensively in the processing of dairy, meat, and soy. These are required to add value to reduced fish landings and sustain profitability.
Electroconductive agarose hydrogels modulate mesenchymal stromal cell adhesion and spreading through protein adsorption
Authors: Casella Alena , Panitch Alyssa , Leach J. Kent 
Published: January 2023

AbstractElectrically conductive biomaterials direct cell behavior by capitalizing on the effect of bioelectricity in tissue homeostasis and healing. Many studies have leveraged conductive biomaterials to influence cells and improve tissue healing, even in the absence of external stimulation. However, most studies using electroactive materials neglect characterizing how the inclusion of conductive additives affects the material's mechanical properties, and the interplay between substrate electrical and mechanical properties on cell behavior is poorly understood. Furthermore, mechanisms dictating how electrically conductive materials affect cell behavior in the absence of external stimulation are not explicit. In this study, we developed a mechanically and electrically tunable conductive hydrogel using agarose and the conductive polymer PEDOT:PSS. Under certain conditions, we observed that the hydrogel physical and electrical properties were decoupled. We then seeded human mesenchymal stromal cells (MSCs) onto the hydrogels and observed enhanced adhesion and spreading of MSCs on conductive substrates, regardless of the hydrogel mechanical properties, and despite the gels having no cell‐binding sites. To explain this observation, we measured protein interaction with the gels and found that charged proteins adsorbed significantly more to conductive hydrogels. These data demonstrate that conductivity promotes cell adhesion, likely by facilitating increased adsorption of proteins associated with cell binding, providing a better understanding of the mechanism of action of electrically conductive materials.
Bone Deterioration in Response to Chronic High-Altitude Hypoxia Is Attenuated by a Pulsed Electromagnetic Field Via the Primary Cilium/HIF-1α Axis
Authors: Hao Xiaoxia , Wang Dan , Yan Zedong , Ding Yuanjun , Zhang Juan , Liu Juan , Shao Xi , Liu Xiyu , Wang Lu , Luo Erping , Cai Jing , Jing Da 
Published: January 2023

ABSTRACT
Chronic high-altitude hypoxia induces irreversible abnormalities in various organisms. Emerging evidence indicates that hypobaric hypoxia markedly suppresses bone mass and bone strength. However, few effective means have been identified to prevent such bone deficits. Here, we assessed the potential of pulsed electromagnetic fields (PEMFs) to noninvasively resist bone deterioration induced by hypobaric hypoxia. We observed that exogenous PEMF treatment at 15 Hz and 20 Gauss (Gs) improved the cancellous and cortical bone mass, bone microstructure, and skeletal mechano-properties in rats subjected to chronic exposure of hypobaric hypoxia simulating an altitude of 4500 m for 6 weeks by primarily modulating osteoblasts and osteoblast-mediated bone-forming activity. Moreover, our results showed that whereas PEMF stimulated the functional activity of primary osteoblasts in hypoxic culture in vitro, it had negligible effects on osteoclasts and osteocytes exposed to hypoxia. Mechanistically, the primary cilium was found to function as the major electromagnetic sensor in osteoblasts exposed to hypoxia. The polycystins PC-1/PC-2 complex was identified as the primary calcium channel in the primary cilium of hypoxia-exposed osteoblastic cells responsible for the detection of external PEMF signals, and thereby translated these biophysical signals into intracellular biochemical events involving significant increase in the intracellular soluble adenylyl cyclase (sAC) expression and subsequent elevation of cyclic adenosine monophosphate (cAMP) concentration. The second messenger cAMP inhibited the transcription of oxygen homeostasis-related hypoxia-inducible factor 1-alpha (HIF-1α), and thus enhanced osteoblast differentiation and improved bone phenotype. Overall, the present study not only advances our understanding of bone physiology at high altitudes, but more importantly, proposes effective means to ameliorate high altitude-induced bone loss in a noninvasive and cost-effective manner. © 2023 American Society for Bone and Mineral Research (ASBMR).
Abstract
Schematic diagram showing the mechanism whereby PEMF treatment counteracts bone loss resulting from chronic hypobaric hypoxia.
New association between splicing factor‐coding gene polymorphisms and the risk of acute lymphoblastic leukemia in southern Chinese children: A five‐center case–control study
Authors: Deng Decheng , Luo Ailing , Li Ming , Yan Yaping , Cai Mansi , Liu Shanshan , Liu Xiaodan , Wang Xueliang , Zhang Xiaohong , Jiang Hua , Liu Xiaoping 
Published: January 2023

AbstractBackgroundThe role of splicing factor‐coding gene polymorphisms in pediatric acute lymphoblastic leukemia (ALL) susceptibility is still unclear.MethodsA case–control designed model was used to estimate the overall risk of pediatric ALL and five single nucleotide polymorphisms (SNPs) of splicing factor‐coding genes in 808 cases and 1,340 controls, which were genotyped using a TaqMan assay. Stratified analysis was performed to explore the association of rs2233911 genotype and pediatric ALL susceptibility. The influence of splicing factor arginine/serine‐rich 1 (SFRS1) polymorphisms on the sensitivity to different chemotherapeutic regimens based on minimal residual disease (MRD) levels was analyzed. The haplotype analysis was adopted to evaluate the association between inferred haplotypes of the splicing factor‐coding genes and pediatric ALL risk.ResultsAmong the five analyzed SNPs, SFRS1 rs2233911 AG/GG exhibited a significant association with increased pediatric ALL risk. The stratified analysis further identified the harmful effect of SFRS1 rs2233911 AG/GG in specific subgroups. Moreover, rs2233911 AG/GG had a protective effect on MRD in marrow of ≥0.01% 12 weeks of Chinese Children Cancer Group chemotherapeutics, but provided a harmful effect on MRD in the marrow of ≥0.01% at days 15–19 of the South China Children Leukemia Group chemotherapeutics. Haplotype analysis of these five SNPs yielded haplotypes ACGCC and ACGTC significantly correlating with increased pediatric ALL susceptibility. On the contrary, haplotypes GCATG and GTACC were linked with remarkably decreased pediatric ALL risk.ConclusionSFRS1 gene polymorphism was associated with increased pediatric ALL risk and indicated that rs2233911 AG/GG might be a potential biomarker for choosing chemotherapeutics.