bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Photophysical Characteristics, Aromaticity, and Stability of π–Extended Acene‐Quinodimethyl Thioamides†
Authors: Yang Guang , Yun Young Ju , Peccati Francesca , Jamhawi Abdelqader M. , Kamatham Nareshbabu , Jockusch Steffen , Jiménez‐Osés Gonzalo , Ayitou A. Jean‐Luc 
Published: August 2023

AbstractPoly‐aromatic systems that contain quinodimethyl (QDM) units are appealing for several photonic and spintronic applications owing to the unique electronic structure, aromaticity, and spin state(s) of the QDM ring. Herein, we report the synthesis and characterization of novel QDM‐based chromophores 1–3, which exhibit unique photo‐excited behavior and aromaticity. Extending the aromatic core with a biphenyl/phenanthryl‐ and a pyrrolo‐fragment led to reducing the optoelectronic bandgap and modulating the photophysics QDM 1–3. Yet, QDM 2 and 3 suffer from “aromaticity imbalance” and become relatively unstable compared to the parent compound QDM 1. Further assessment of local aromaticity using computational tools revealed that the pseudo‐quinoidal ring B is the main driving force allowing to easily populate the excited triplet state of these chromophores. The present study provides complementary guidelines for designing novel non‐classical poly‐aromatic systems.
Tailoring Cu Electrodes for Enhanced CO2 Electroreduction through Plasma Electrolysis in Non‐Conventional Phosphorus‐Oxoanion‐Based Electrolytes
Authors: Elnagar Mohamed M. , Menezes Pramod V. , Parada Walter A. , Mattausch Yannick , Kibler Ludwig A. , Mayrhofer Karl J. J. , Jacob Timo 
Published: August 2023

AbstractThis study presents a green, ultra‐fast, and facile technique for the fabrication of micro/nano‐structured and porous Cu electrodes through in‐liquid plasma electrolysis using phosphorous‐oxoanion‐based electrolytes. Besides the preferential surface faceting, the Cu electrodes exhibit unique surface structures, including octahedral nanocrystals besides nanoporous and microporous structures, depending on the employed electrolyte. The incorporation of P‐atoms into the Cu surfaces is observed. The modified Cu electrodes display increased roughness, leading to higher current densities for CO2 electroreduction reaction. The selectivity of the modified Cu electrodes towards C2 products is highest for the Cu electrodes treated in Na2HPO3 and Na3PO4 electrolytes, whereas those treated in Na2H2PO2 produce the most H2. The Cu electrode treated in Na3PO4 produces ethylene (23 %) at −1.1 V vs. RHE, and a comparable amount of acetaldehyde (15 %) that is typically observed for Cu(110) single crystals. The enhanced selectivity is attributed to several factors, including the surface morphology, the incorporation of phosphorus into the Cu structure, and the formation of Cu(110) facets. Our results not only advance our understanding of the influence of the electrolyte's nature on the plasma electrolysis of Cu electrodes, but also underscores the potential of in‐liquid plasma treatment for developing efficient Cu electrocatalysts for sustainable CO2 conversion.
Compact SCSRR‐based quad‐band antenna for Bluetooth, WiMAX, WLAN, and fixed‐satellite services
Authors: Balakrishnan Neeththi Aadithiya , Britto Elizabeth Caroline 
Published: August 2023

SummaryThis research describes the detailed analysis and design of the compact complex‐free structural metamaterial quad band radiating element applicable for Bluetooth, WiMAX, WLAN, and fixed‐satellite service. The radiating element designed is composed of an inner angle‐rotated circular Split Ring Resonator (SRR) placed within the outer square‐shaped SRR interlinked by a strip to design the multiband operational characteristics and is fed by a coplanar waveguide. Suggested radiating element is imprinted over the FR4 substrate material with the electrical dimension of 28 × 31.26 × 0.8 mm3. The initial outer‐closed square ring offers dual‐band operation by resonating at 2.8 and 8.5 GHz frequencies, and the incorporation of a circular SRR offers quad‐band operation. The unique negative permeability feature of the proposed Square and Circular Split Ring Resonator (SCSRR) structure is extracted, and its band characteristics are analyzed. Results obtained from the simulated radiating element are validated with the fabricated antenna. The measured E plane pattern resembles a numeric eight shape, and the H plane pattern is omnidirectional. Suggested SCSRR antenna offers a gain of above 3.2 dBi in all the operating bands.
Short‐term outcomes after sodium‐glucose cotransporter‐2 inhibitor initiation in a cohort of heart failure patients
Authors: Pérez Martínez Bryan O. , Adie Sarah K. , Marshall Vincent D. , Konerman Matthew C. 
Published: August 2023

AbstractAimsSodium‐glucose cotransporter‐2 inhibitors (SGLT2i) decrease mortality and risk of hospitalization in patients with heart failure with reduced ejection fraction (HFrEF). SGLT2i have a natriuretic effect shortly after initiation, followed by a lasting osmotic diuretic effect. We sought to evaluate rates of acute kidney injury (AKI) and therapy discontinuation with SGLT2i initiation in a real‐world cohort of HFrEF patients.Methods and resultsWe abstracted data on 200 patients with HFrEF initiated on a SGLT2i in the outpatient setting at the University of Michigan (between 1 July 2016 and 2 July 2022). Our co‐primary endpoints were rate of AKI and discontinuation of SGLT2i. A total of 200 patients were included. The majority of patients were male (64%) with a mean left ventricular ejection fraction (LVEF) of 27%. One hundred and four (52%) patients had diabetes mellitus. Most patients exhibited New York Heart Association class II (51.5%) or III (33.5%) symptoms. The majority of patients (54%) were taking an angiotensin‐receptor neprilysin inhibitor. The mean daily furosemide equivalent diuretic dose was 93.3 mg. AKI occurred in 22 patients and 18 patients discontinued their SGLT2i. Yeast infection (n = 6), hypotension (n = 5), and AKI (n = 4) were the most common reasons for discontinuation. Using receiver operating characteristic curve analysis, the strongest models for AKI were A1C [area underneath its curve (AUC) = 75.8, empirical confidence interval (ECI) 66.5–83.5]; baseline serum creatinine (SCr) (AUC = 72.0, ECI 65.7–78.7); LVEF (AUC = 67.6, ECI 58.4–75.8); and furosemide equivalent diuretic dose (AUC = 66.0, ECI 57.5–74.6). Similarly, the strongest positive models for SGLT2i discontinuation were A1C (AUC = 81.1, ECI 74.8–87.2); baseline SCr (AUC = 67.4, ECI 58.7–75.5); LVEF (AUC = 68.7, ECI 58.9–76.5); and furosemide equivalent diuretic dose (AUC = 67.2, ECI 58.2–76.0).ConclusionsA1C was the strongest model of AKI, and SGLT2i discontinuation in HFrEF patients started on SGLT2i. Glucosuria may be related to this effect. Patients with higher baseline SCr on higher doses of loop diuretics may be at greater risk of these outcomes. Future prospective studies will be needed to further evaluate these findings and other models of AKI and SGLT2i discontinuation to guide clinical use of SGLT2 inhibitors.
Stabilizing layered superlattice MoSe2 anodes by the rational solvation structure design for low‐temperature aqueous zinc‐ion batteries
Authors: Lv Zeheng , Kang Yuanhong , Tang Rong , Yang Jin , Chen Guanhong , Hu Yuhan , Lin Pengxiang , Yang Huiya , Wu Qilong , Zhang Minghao , Chen Fenghua , Peng Yueying , Yang Yang , Zhao Jinbao 
Published: August 2023

AbstractAqueous zinc‐ion batteries (AZIBs) have attracted widespread attention due to their intrinsic merits of low cost and high safety. However, the poor thermodynamic stability of Zn metal in aqueous electrolytes inevitably cause Zn dendrites growth and interface parasitic side reactions, resulting in unsatisfactory cycling stability and low Zn utilization. Replacing Zn anode with intercalation‐type anodes have emerged as a promising alternative strategy to overcome the above issues but the lack of appropriate anode materials is becoming the bottleneck. Herein, the interlayer structure of MoSe2 anode is preintercalated with long‐chain polyvinyl pyrrolidone (PVP), constructing a periodically stacked p‐MoSe2 superlattice to activate the reversible Zn2+ storage performance (203 mAh g−1 at 0.2 A g−1). To further improve the stability of the superlattice structure during cycling, the electrolyte is also rationally designed by adding 1,4‐Butyrolactone (γ‐GBL) additive into 3 M Zn(CF3SO3)2, in which γ‐GBL replaces the H2O in Zn2+ solvation sheath. The preferential solvation of γ‐GBL with Zn2+ effectively reduces the water activity and helps to achieve an ultra‐long lifespan of 12,000 cycles for p‐MoSe2. More importantly, the reconstructed solvation structure enables the operation of p‐MoSe2||ZnxNVPF (Na3V2(PO4)2O2F) AZIBs at an ultra‐low temperature of −40°C, which is expected to promote the practical applications of AZIBs.
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy
Authors: Hanaya Ryosuke , Kubota Yuichi , Mizobuchi Masahiro , Iida Koji , Ono Tomonori , Motooka Hiromichi , Nakano Naoki , Fujimoto Ayataka , Iwasaki Masaki , Fukuda Masafumi , Kondo Akihiko , Uruno Katsuhisa , Yamamuro Shintaro , Yamaguchi Kohei , Onishi Kisaki , Ngo Leock Y , Inoue Yushi 
Published: August 2023

AbstractObjectivePerampanel is an oral anti‐seizure medication, which is approved in Japan for focal‐onset seizures, with/without focal to bilateral tonic–clonic seizures, as monotherapy/adjunctive therapy in patients aged 4 years and older. Treatment for generalized tonic–clonic seizures as adjunctive therapy in patients aged 12 years and older is approved as well. We evaluated the feasibility of intravenous (IV) administration of perampanel as an alternative to oral administration.MethodsStudy 240 (NCT03754582) was an uncontrolled, open‐label study of IV perampanel, conducted in 21 Japanese patients with epilepsy who received a stable dose of 8–12 mg/day of oral perampanel. Patients received 30‐minute IV infusions at equivalent daily doses of oral perampanel for 4 days, then were switched back to oral perampanel. Safety, tolerability, plasma concentration, and maintenance of efficacy throughout the transition between IV and oral dosing of perampanel were assessed. As supportive data, a subgroup analysis was also conducted using data from healthy Japanese subjects (n = 18) who were enrolled in Study 050 (NCT03376997) investigating the pharmacokinetics and safety of IV perampanel in healthy subjects who received an IV infusion (30‐, 60‐, or 90‐minute) of perampanel 12 mg and a single oral administration of perampanel 12‐mg tablet.ResultsIn Study 240, the transition between 30‐minute IV and oral perampanel dosing was associated with a ≤1.4‐fold increase in the mean change in maximum observed concentration of perampanel. Seizure outcomes demonstrated no considerable changes in efficacy before, during, or after 30‐minute IV dosing of perampanel. The safety profiles were similar between IV and oral formulations. In Study 050, the pharmacokinetics of 30‐ or 60‐minute IV infusion of perampanel further support the interchangeability between oral and IV formulations in the Japanese subjects.SignificanceThese results support that 30‐minute IV perampanel may be a potential short‐term alternative to oral formulations for patients with epilepsy.
Validating and developing a shortened version of the detail and flexibility (DFlex) questionnaire for eating disorders, anxiety and depression
Authors: Giles Sarah , Hughes Elizabeth K. , Fuller‐Tyszkiewicz Matthew , Kiropoulos Litza , Donnelly Brooke , Russell Janice , Krug Isabel 
Published: August 2023

AbstractObjectiveTo validate the original and a shortened version of the Detail and Flexibility (DFlex) Questionnaire.MethodConfirmatory factor analyses, internal consistency, and discriminant validity estimates were conducted within individuals with a diagnosis of an eating disorder (ED) (n = 124), an anxiety disorder and/or depression (n = 219), and a community sample (n = 852) (Part 1). Convergent validity of the DFlex through comparisons with the Autism Spectrum Quotient, Wisconsin Card Sorting Task, and Group Embedded Figures Task was undertaken within a combined ED and community sample (N = 68). Test‐retest reliability of the DFlex was also examined across 2 years in a community sample (N = 85) (Part 2).ResultsThe original factor structure of the DFlex was not supported. Hence, a shortened version, the DFlex‐Revised, was developed. Good discriminant validity was obtained for the DFlex and DFlex‐Revised, however, support for convergent validity was mixed. Finally, the 2‐year test‐retest reliability for the two DFlex versions was found to be low, suggesting potential malleability in construct over this timeframe.ConclusionsFurther research is needed to validate the DFlex in clinical and non‐clinical populations using different neurocognitive tests. Test‐retest, using varied time intervals, should also be assessed.
Performance analysis of multistage high‐temperature heat pump cycle
Authors: Kim Seon Tae , Hegner Robert , Özuylasi Göksel , Stathopoulos Panagiotis , Nicke Eberhard 
Published: August 2023

AbstractHigh‐temperature heat pumps (HTHPs) that can supply heat at temperatures at and above 200°C have the potential to increase energy efficiency and decrease carbon dioxide (CO2) emissions in industrial processes. In this study, three reversed Rankine cycles using water vapor (R‐718) as the working medium, with different intercooling strategies, were proposed and their performance has been investigated. The thermodynamic performance was estimated under different operating conditions, and the optimal pressure ratio (PR) between compression stages was found to be where both compressors had the same PR. The thermodynamic efficiency, φ, and exergy efficiency, ηexergy, were also analyzed at the optimum PR. The cycles that employed an intercooler between the first and second compression stages (IC cycles) showed higher φ and ηexergy values compared with the spray‐injection cycle. Among the IC cycles, the IC‐in cycle, with an inward flow direction of heat sink to the IC, demonstrated higher efficiency and deliverable temperature, Tsink out, than the spray‐injection and IC‐out cycles. To assess the practical impact of the HTHP cycles on industrial CO2 reduction, the PR for each stage was limited to 2.5. Theoretically, the IC‐in cycle could achieve a coefficient of performance of 5.86 with a Tsink out of 200°C or higher when Tevap and Tcond were at 90°C and 150°C, respectively. Additionally, the study demonstrated that the proposed HTHP system has the potential to reduce CO2 emissions by 8.1% in 2030 for industrial heat supply at temperature up to 200°C, by replacing existing industrial fossil boilers with high‐efficiency HTHP.
MUDROID: Android malware detection and classification based on permission and behavior for autonomous vehicles
Authors: Tang Binhui , Da Hai , Wang Bochang , Wang Junfeng 
Published: August 2023

AbstractWith the growing popularity of autonomous vehicles, ensuring their safety has become a significant concern. Vehicle manufacturers have incorporated the Android operating system to enhance user convenience. However, the Android operating system's diversity and vulnerability may significantly impact autonomous vehicles because these natures lead to a critical threat in autonomous vehicle security: Android malware. The complex nature of multi‐data sources fusion in autonomous driving systems has resulted in low detection efficiency and accuracy for Android malware. Given the security requirements for autonomous‐driving systems, this article presents an Android malware classification method centered around the multifeature fusion and deep learning architecture designed to detect and classify Android malware within autonomous‐driving systems. The proposed MUDROID framework relies on the Android permission mechanism and behavioral feature to formulate a malware classification model. Comprising four essential components—feature extraction, representation, multifeature fusion, and classifier training, MUDROID leverages the advantages of CNN and GCN combination model and is adept at extracting and interpreting multidimensional features, consequently constructing a multifeature fusion classifier to amplify the efficiency and accuracy of Android malware detection and classification. The experiment results support MUDROID's superior classification performance, with an impressive Android malware detection accuracy rate of 98.69% and family classification (95.42%). The proposed method can detect and classify Android malware effectively, thus elevating the security and robustness of the self‐driving system. Additionally, the approach in this article also addresses feature representation issues in detecting malware variants, facilitating the recognition of Android malware variants across diverse platforms.
Pyracantha as a promising functional food: A comprehensive review on bioactive characteristics, pharmacological activity, and industrial applications
Authors: Song Shengnan , Li Jiaxun , Liu Haoyao , Qi Yunyang , Subbiah Vigasini , Sharifi‐Rad Javad , Setzer William N. , Suleria Hafiz A. R. 
Published: August 2023

AbstractPyracantha is a plant with edible and medicinal value and widely distributed from eastern Asia to southern Europe but is underutilized and has great potential. As scientists gradually study its properties, it was found that Pyracantha contains various phytochemical components such as pigments and phospholipids. Meanwhile, Pyracantha is also rich in phenolic substances, such as flavonoids. The extract of Pyracantha shows strong biological properties, such as inhibition of tyrosinase activity, anti‐oxidative, and tumor‐preventive effects. Pyracantha bioavailability releases quantities of compounds in the food matrix from the digestive process that are important for its health‐promoting properties. The extraction of biologically active substances in Pyracantha would be applied in various aspects. Their extracts can also be used as health food, food additives, and cosmetics. As the interaction of phytochemicals, proteins, and phenolic compounds can affect the pharmacological activity and bioavailability of Pyracantha, it is important to understand the mechanism of effect, which can further allow consumers to choose a healthier Pyracantha dietary culture. This review aims to prove the nutritional components and pharmacological activities of Pyracantha and to make consumers better aware of the benefits of Pyracantha in connection with their bioavailability and application, in order to provide a reference for further research and development of Pyracantha resources.
Facing Progress with Pragmatism: Telemedicine and Family Medicine
Authors: Tunzi Marc 
Published: August 2023

AbstractThe singular expertise of family physicians is the ability to manage complexity with pragmatism, both clinically and ethically. Telemedicine raises multiple questions about the nature of the patient‐physician relationship as manifested in clinical encounters. Some of these questions are concerning, underscoring the need to assess whether medical care is better with this new technology—or if it is just different or maybe even worse. It seems clear, however, that, regardless of its limitations, telemedicine is here to stay. The pragmatic complex ethical question, then, is how all of us together—both medical professionals and society at large—will manage it.
Evaluation of the novel therapeutic anti‐CCR7 antibody CAP‐100 as an add‐on therapy in chronic lymphocytic leukemia patients receiving venetoclax
Authors: Mateu‐Albero Tamara , Marcos‐Jimenez Ana , Delgado‐Wicke Pablo , Terrón Fernando , Loscertales Javier , López‐Matencio José María Serra , Muñoz‐Calleja Cecilia , Cuesta‐Mateos Carlos 
Published: August 2023

AbstractThe Bruton's tyrosine kinase inhibitor ibrutinib and the B‐cell lymphoma 2 anti‐apoptotic protein inhibitor venetoclax provide high response rates in chronic lymphocytic leukemia (CLL). However, there is a growing number of patients that relapse after treatment or show refractory disease, thus new targets and agents are still needed. We have previously reported the chemokine receptor CCR7 as a relevant deregulated target in CLL and have developed CAP‐100, a novel therapeutic anti‐CCR7 antibody that is under evaluation for relapse/refractory CLL (NCT04704323). While CCR7 expression has been shown to be down‐modulated in CLL patients treated with ibrutinib, whether venetoclax acts in a similar manner remains unaddressed. Here, we aimed to document the impact of venetoclax on CCR7 expression in CLL cells, as well as on the pre‐clinical activity of CAP‐100. To this end, we addressed CCR7 expression by flow cytometry and the antibody efficacy by means of in vitro chemotactic and antibody‐dependent cell‐mediated cytotoxicity (ADCC) assays. Our data indicate that venetoclax treatment did not significantly modify CCR7 expression pattern nor CAP‐100 mechanisms of action. Together, these findings support CAP‐100 as an adjuvant therapy to venetoclax that may introduce additional modes of action in CLL therapy.
Challenges and solutions in clinical research during the COVID‐19 pandemic: A narrative review
Authors: Nomali Mahin , Mehrdad Neda , Heidari Mohammad Eghbal , Ayati Aryan , Yadegar Amirhossein , Payab Moloud , Olyaeemanesh Alireza , Larijani Bagher 
Published: August 2023

AbstractBackground and AimsThe COVID‐19 pandemic has presented significant challenges to clinical research, necessitating the adoption of innovative and remote methods to conduct studies. This study aimed to investigate these challenges and propose solutions for conducting clinical research during the pandemic.MethodsA narrative review was conducted (approval ID: IR.AMS.REC.1401.029), utilizing keyword searches in PubMed and Web of Science (WOS) citation index expanded (SCI‐EXPANDED) from January 2020 to January 2023. Keywords included COVID‐19, clinical research, barriers, obstacles, facilitators and enablers.ResultsOut of 2508 records retrieved, 43 studies were reviewed, providing valuable insights into the challenges and corresponding solutions for conducting clinical research during the COVID‐19 pandemic. The identified challenges were categorized into four main groups: issues related to researchers or investigators, issues related to participants and ethical concerns, administrative issues, and issues related to research implementation. To address these challenges, multiple strategies were proposed, including remote monitoring through phone or video visits, online data collection and interviews to minimize in‐person contact, development of virtual platforms for participant interaction and questionnaire completion, consideration of financial incentives, adherence to essential criteria such as inclusion and exclusion parameters, participant compensation, and risk assessment for vulnerable patients.ConclusionThe COVID‐19 pandemic has significantly impacted clinical research, requiring the adaptation and enhancement of existing research structures. Although remote methods and electronic equipment have limitations, they hold promise as effective solutions during this challenging period.