bluuebunny/crossref_metadata_2025_split huggingface dataset:
USING TAMSULOSINE IN THE MANAGEMENT OF LOWER URETERIC CALCULI: OUR EXPERIENCE OF MEDICAL EXPUSIVE THERAPY OF URETERIC CALCULI IN A RANDOMIZED CONTROLLED TRIAL
Authors: Hassan Raza Asghar  , Manzoor Ahmed Malik  , Muhammad Adil Chaudhary  , Mahboob Alam Chishti  , Zulfiqar Saleem  , Aleena Ahmed Khan  
Published: March 2023

Background: Lower ureteric calculi can be treated by different modalities. There are many minimally invasive interventional (e.g.,ESWL, ureterorenoscopy, the holmium: YAG laser and basket devices) as well as expectant (watchful waiting) treatments are in practice for the management of distal ureteric calculi. selected method depend on the type of equipment available, location, type and size of stone, needs of the patient and skills of the surgeon. Most of the work on the potency of tamsulosin in lower ureteric calculi expulsion has been done in the developed countries.
Methods: Our randomized controlled trial in Avicenna Hospital Lahore included 100 patients over 18 years of age with stone Size ≤8mm in distal one third of ureter. Patients were randomly assigned into two groups (A & B). Group A Patients were given Capsule Tamsulosin 0.4 mg, once daily up to four weeks while group B patients were given placebo, one Capsule daily up to four weeks. The final result was the expulsion rate.
Informed consent was obtained from all the patients. Stone Expulsion time, analgesia requirement, need for
hospitalization and drug adverse effects were secondary endpoints.
Results: A total of 49 patients in group A and 48 patients in group B came for follow up, therefore 97 out of 100 patients were evaluated. Mean age of the patients was 36.34 years (range 18–57 years). Mean stone size was 5.78 mm (range 4–8 mm) in largest dimension. A stone expulsion rate of 85.71% (42 patients) was noted in group A and 54.20% (26 patients) in group B. Group A showed a statistically significant advantage in terms of stone expulsion rate (p=0.032). Considering expulsion time in days group A demonstrated statistically significant advantage (p=0.015). Regarding age, sex, stone size and stone lateralization (right/left), there was no remarkable difference between the group A and B. No drug adverse effects were seen in both the groups.
Conclusion: Tamsulosine can be used as medical expulsion therapy in lower ureteric calculi of size less than or equal to 8mm.
COMPARING THE EFFICACY OF CONCOMITANT THERAPY WITH THE STANDARD TRIPLE REGIMEN AS FIRST LINE THERAPY OF HELICOBACTOR PYLORI ERADICATION
Authors: Attique Abou Bakr  , Naeem Aslam  , Tayyab Shahzad  , Imran Mehfooz  
Published: March 2023

Objective: To compare the effectiveness of Concomitant therapy with standard triple regimen in H.pylori Eradication.
Methods: It was a randomised control trial at OPD of Department of Gastroenterology, Jinnah Hospital Lahore and involved 170 patients, who fullfilled the selection criteria of study were enrolled in the study from OPD of Department of Gastroenterology, Jinnah Hospital Lahore. 85 cases were given Concomitant therapy (Group-A) and 85 cases were given Standard triple regimen (Group-B). Informed consent was obtained. Demographic information (name, age, and sex) were taken. The mean age was 40.43 ± 17.01 years in the Concomitant therapy group and 42.99 ± 12.98 years in the Standard triple regimen group. In group A, 62% cases had ages less than 45 years, and 37.6% of cases had age 45 years or above. In group B, 68.2% cases had an age less than 45 years and 31.8% of cases had an age of 45 years and above. In group A, 50.6% cases were male and 49.4% cases were female. In group B, 72.9% cases were male and 27.1% cases were female. In group A, 58.8%, 22.4%, and 18.8% of cases had low, middle, and high socioeconomic status respectively. In group B, 57.6%, 29.4 and 13% of cases had low, middle, and high socioeconomic status respectively.
In the Concomiant therapy group, eradication was achieved in 93.8%. In conventional triple regimen, eradication was achieved in 61.4% cases (p-value<0.001).
Conclusions: Eradication achievement was significantly more common with Concomitant therapy as compared to the conventional triple regimen. Concomitant therapy was much effective than the Standard triple regimen in all age groups, both genders, and all socioeconomic groups.
POTENSI EKSTRAK BUAH LADA HITAM (Piper nigrum L.,) dan PIPERIN DALAM MENINGKATKAN AKTIVITAS ANTIBAKTERI OBAT-OBAT ANTITUBERKULOSIS
Authors: Hamka Zulfahmi 
Published: March 2023

Tuberkulosis (TB) adalah masalah kesehatan masyarakat di seluruh dunia yang disebabkan oleh bakteri Mycobacterium tuberculosis (M.tb). Karena tingkat kepatuhan pasien yang kurang baik muncul masalah dalam pengobatan TB yaitu resistasi terhadap beberapa jenis obat TB. Saat ini isolate klinis M.tb sudah banyak yang resisten terhadap obat anti tuberculosis (OAT). Penelitian ini bertujuan untuk menentukan pengaruh pemberian ekstrak buah lada hitam (EELH) dalam meningkatkan aktivitas antibakteri dari OAT terhadap bakteri M.tb resisten isoniazid (INH) . Proses ekstraksi buah lada hitam menggunakan metode sokhlet dengan pelarut etanol 70% dan pengujian antituberkulosis Metode Bactec MGIT 960 dan bakteri yang digunakan adalah M.tb resisten INH. Hasil penelitian ini menunjukkan bahwa ekstrak etanol lada hitam pada konsentrasi maksimum 120 ppm tidak memiliki kemampuan ataupun menambah aktivitas INH dalam menghambat pertumbuhan bakteri M.tb resisten INH namum piperin dalam konsentrasi 15 ppm dapat menghambat pertumbuhan M.tb resisten INH.
MENINGKATKAN KESADARAN MASYARAKAT AKAN PENTINGNYA PEMENUHAN GIZI DALAM MENCEGAH STUNTING DI DESA SUKAMAJU KECAMATAN LABUAN KABUPATEN PANDEGLANG
Authors: Hamer Welliam , Bryan Maliki Billy , Mapruhah Aap 
Published: March 2023

Stunting is a chronic malnutrition problem caused by lack of nutritional intake for a long time, resulting in growth disorders in children, namely the child's height is lower or shorter (short) than the standard age. In addition to nutritional factors, stunting is caused by a lack of public knowledge, especially mothers who have infants and toddlers about stunting. The stunting control model is through increasing family empowerment related to the prevention of infectious diseases, utilizing the yard as a source of family nutrition and improving environmental sanitation. Implementation of education carried out by Untirta students in Group 96 of Kuliah Kerja Mahasiswa (KKM) in Sukamaju Village, Labuan District, Pandeglang Regency through socialization about stunting prevention. Some of the activities consist of main programs and supporting programs that focus on health, education, entrepreneurship, and the environment. The result is the implementation of a work program by creating creative content that can increase public awareness. In addition, the implementation of KKM in Sukamaju Village received a very positive response from the community.
Keywords: Comunity Awareness, Nutrition Fulfilment, Stunting
PEMBUATAN NOMOR INDUK BERUSAHA (NIB) UNTUK KESADARAN LEGALITAS USAHA BAGI UMKM KELURAHAN DUKUH SUTOREJO
Authors: Diana Laksmi , Akbhari Izzatira , Fadhilah Ariqotul , Hidayaturracman Hammada 
Published: March 2023

At this time, Dukuh Sutorejo Village experienced an increase in the number of UMKM. In 2021 the
number of UMKM was recorded to reach 1,070 UMKM, this is due to the increasing number of people
who want to open their own businesses due to the Covid-19 pandemic where many employees have been
laid off by the company, it is difficult to find new jobs, and other problems. However, there are still many
UMKM actors in the Dukuh Sutorejo Village area who do not know and understand the importance of
business legality in this case the creation of a Business Identification Number (NIB), because some people
have an understanding that managing business permits and legality is a complicated matter and takes a
long time. Meanwhile, the Business Identification Number (NIB) itself plays an important role in the efforts
of business actors. There are many advantages to having a Business Identification Number (NIB), one of
which is the legality of the business. Issuance of Business Identification Number (NIB) can be done through
OSS (Online Single Submission). The purpose of this Community Service activity is so that UMKM actors
in Dukuh Sutorejo Village, Surabaya can understand and know how to make business licenses through
OSS and have business legality, in this case in the form of a Business Identification Number (NIB). The
method used in this community service activity is to educate about the procedures for making Business
Identification Number (NIB) and it is carried out using the door to door method where this activity is
carried out by visiting the residence of each UMKM in the Sutorejo Hamlet area. The result of this
community service activity is the issuance of a Business Identification Number (NIB) for UMKM actors
in Dukuh Sutorejo Village.
SCIENTIFIC RESEARCH WORK OF THE MUSEUM AS THE MAIN DIRECTION OF MUSEUM ACTIVITIES (On a work experience example of the Central State Museum of the Republic of Kazakhstan)
Authors: Temirton Galiya 
Published: March 2023

Abstract. In this article, one of the main directions of museum work - research activities based on its fund collections - considered on the example of the oldest museum both in Kazakhstan and in Central Asia. This is primarily socio-humanitarian research of a source study nature, which focuses on the cameral processing, classification, identification and determination of the documentary properties of museum objects, as well as their scientific cataloguing. The research programs carried out by the museum demonstrate the museum's research activities, both in the development of specialized disciplines and in the popularization of the country's historical and cultural heritage. The focus is on museological case studies, which are intended to form new knowledge in the field of methodology of identification, collection, storage, processing of museum objects, as well as the study of museum collections as an important scientific source base.
Materials and methods: The sources for the article were the materials of the results of several museum scientific-applied researches, based on the stock collections of Kazakhstan museums, which implemented by the staff of the Central State Museum of Kazakhstan within the framework of state tenders on program-targeted financing. Thus, the materials (sources) for the study were works of art and culture, in particular, the watercolor paintings of the first Kazakh professional artist A.Kasteev from the collections of the Central State Museum and other museums of Kazakhstan. The materials in this thematic project were studied as representing historical and ethnographic sources on the traditional culture of the Kazakh people. The materials of the research also include ethnographic objects on Kazakh traditional applied culture in the chronological range covering the end of the XVIII and the beginning of the XX centuries, as well as archaeological collections from the middle ages.
In accordance with the different nature of museum objects, research methods appropriate to the profile of scientific study were used for example, systematization and classification of ethnographic objects from museum collections were applied thematically and problematically, as well as studying objects according to general typological features - typologization, identification, comparison of analogues, historical and cultural, contextual and other scientific methods. Historical-typological and comparative-contrast methods were used to analyze the main categories of archaeological material.
БОТАЙСКАЯ КУЛЬТУРА КАК ЧАСТЬ УРАЛО-ИРТЫШСКОЙ КУЛЬТУРНО-ИСТОРИЧЕСКОЙ ОБЛАСТИ
Authors: Шакшаков Куаныш 
Published: March 2023

Аннотация. В данной статье автором исследуется ареал распространения памятников ботайской культуры на территории Урало-Иртышской культурно-исторической области. Изучена научная литература по энеолиту Урало-Иртышского междуречья и сопредельных регионов Великой евразийской степи. Собраны и проанализированы материалы научных отчетов прошлых лет (из архивов, музеев и библиотек регионов Казахстана – Алматы, Петропавловск). Осуществлены археологические разведки, исследования в полевых сезонах 2021-2022 годов на территории ряда областей Казахстана. Изучен остеологический, керамический материал периода энеолита. Методом аналогии, анализа и синтеза археологических данных получены предварительные результаты, выдвинуты гипотезы по распространению и существованию в древности поселений, идентичности памятников ботайской культуры как значимой части Урало-Иртышской культурно-исторической области.
Материалы и методы исследования: Материалом исследования послужили памятники ботайской культуры и их степень распространения на территории Урало-Иртышского междуречья, проведены аналогии памятников ботайской культуры с памятниками Урало-Иртышской культурно-исторической общности, изучена историография по энеолиту Урало-Иртышского междуречья и сопредельных регионов Великой евразийской степи. Осуществлены археологические разведки, полевые исследования на территории ряда областей Казахстана. Изучен остеологический, керамический материал периода энеолита. Методом анализа и синтеза археологических данных получены предварительные результаты, выдвинуты гипотезы по рапространению и существованию в древности поселений, идентичности памятников ботайской культуры как значимой части Урало-Иртышской культурно-исторической области.
Teaching Digital Circuit Class and Cultivating Students' Innovation Ability Based on Curriculum Thinking
Authors: Zhu Hongli 
Published: March 2023

Digital circuit is an important course in the major of electronic information. In the teaching of the digital circuit course, in addition to imparting basic knowledge and skills, it should also focus on the construction of ideology and politics to promote the overall development of students. This paper discusses the following aspects based on the construction of the digital circuit course Civics in colleges and universities: first, the digital circuit course should focus on the ideological and political education of students.
Second, the teaching content of the digital circuit course should keep pace with the times, follow the pace of industry development, focus on practice and application, so that students can master the latest technology and tools, with the ability to solve practical problems and practical experience. Finally, the digital circuit course should focus on the cultivation of students' innovation ability, encourage students to actively participate in research projects and practical activities, and provide opportunities and platforms to help students give full play to their strengths and realize the unity of personal and social values.
Pulmonary Function Test of Fish Mongers in Port Harcourt Metropolis
Authors: Abiye Tamuno-Opubo, , Oluchi Stanley, Rosemary , Iyingiala Austin-Asomeji, , Adetomi Bademosi , George Abiye , Chibuike Obiandu , Crowther Idonibo, Iminabo 
Published: March 2023

Aim: This study investigated the pulmonary function test of fish mongers in Port Harcourt metropolis.
Study Design: Cross-sectional study
Place and Time of Study: Port Harcourt, Rivers state, Nigeria. January 2021 – July 2021.
Method: A comparative assessment of 100 subjects were carried out in the course of this study with 50 been the fish mongers and the other 50 non fish mongers. The Forced expiratory volume (FEV), the force vital capacity (FVC), the FEV1/ FVC Ratio among fish mongers and non-fish mongers were determined.
Results: The mean ages of both categories of the subjects indicated 39 years for fishmongers and 20.89 for non-fishmongers. This study found out that there were elevated levels of systolic and diastolic blood pressures in the fishmonger subjects compared to their non-fishmonger. The FVC, FEV1 and FEV6 mean values were found to be non-significantly reduced in the fishmonger group compared to their counterparts.
Conclusion: These findings suggest that it is important that fishmongers and their likes be more conscious to their predisposition to the risk of respiratory and cardiovascular diseases. As occupation predisposes them to negative impact on their lung health, and, subsequently, on cardiovascular health following constant exposure to smoke and physical inactivity.
Multi‐Scale Modeling of Tunneling in Nanoscale Atomically Precise Si:P Tunnel Junctions
Authors: Donnelly Matthew B. , Munia Mushita M. , Keizer Joris G. , Chung Yousun , Huq A. M. Saffat‐Ee , Osika Edyta N. , Hsueh Yu‐Ling , Rahman Rajib , Simmons Michelle Y. 
Published: March 2023

AbstractControlling electron tunneling is of fundamental importance in the design and operation of semiconductor nanostructures such as field effect transistors (FETs) and quantum computing device architectures. The exponential sensitivity of tunneling with distance requires precise fabrication techniques to engineer the desired device dimensions to achieve the appropriate tunneling resistances/tunnel rates. This is particularly important for high fidelity spin readout and qubit exchange in quantum computing architectures. Here, it is shown by combining precision fabrication techniques with accurate atomistic modeling, predictive device design criteria are achieved at atomic length scales. Such a tool is useful when devices become more complex or have arbitrary shapes/geometries. In particular, in this study, atomic precision patterning of monolayer degenerately phosphorus‐doped silicon tunnel junctions patterned by scanning tunnelling microscopy lithography and tight‐binding non‐equilibrium Green's function (TB‐NEGF) modeling is combined to describe the dependence of tunnel junction resistance RT on junction length. An agreement with experiment to within a factor of 2 over 4 orders of magnitude in RT is found, and this model allows to accurately determine the barrier height V0 = 57.5 ± 1 meV and lateral seam sxy = 0.39 ± 0.01 nm in these nanoscale junctions. This study confirms the use of the TB‐NEGF formalism to accurately model highly doped atomically precise tunnel junctions in silicon. Further applications of this model will enable improved device performance at the nanoscale.
Layered Double Hydroxide with Interlayer Quantum Dots and Laminate Defects for High‐Performance Supercapacitor
Authors: Yang Qingjun , Li Zihua , Xu Bingang 
Published: March 2023

AbstractOwing to the flexible adjustability of laminates, layered double hydroxides (LDHs) can achieve enhanced conductivity and capacitance. However, the regulation of interlayer activity is a great challenge because of the unconquerable charge repulsion between laminates. Herein, a dual‐activity design of LDHs is uniquely realized, including laminate defects and interlayer ZnS quantum dots (QDs). Via pre‐embedding Zn2+ and controllable vulcanization, ZnS‐QDs interpenetrate between CuCo‐LDH layers, exposing abundant active sites and widening the layer spacing. Meanwhile, sulfur replaces part of the oxygen on the laminates to form rich oxygen vacancies (CuCo‐LDH‐S), which does not damage the layered spatial structure and ensures the fast ions/electron transport. Theoretical calculations indicate that the new active centers exhibit higher charge density as compared to CuCo‐LDH. Moreover, the copper foam directly provides copper source to ensure that CuCo‐LDH‐S/ZnS‐QDs present a 3D self‐supporting structure with ultrastability. Hence, it delivers an ultrahigh capacitance of 7.82 F cm−2 at 2 mA cm−2 and 4.43 F cm−2 at 20 mA cm−2. The hybrid supercapacitors display an outstanding energy density of 299 µWh cm−2 at power density of 1600 µW cm−2, with outstanding capacitance retention of 102.3% and coulomb efficiency of 96.2% after 10 000 cycles.
A Strategy of Fenton Reaction Cycloacceleration for High‐Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling
Authors: Huang Lin , Feng Jie , Zhu Jiaoyang , Yang Jing , Xiong Wei , Lu Xuanyi , Chen Sijin , Yang Sugeun , Li Yan , Xu Yikai , Shen Zheyu 
Published: March 2023

AbstractThe emerging tumor ferroptosis therapy confronts impediments of the tumor microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H2O2, and a powerful intracellular redox balance system that eliminates toxic reactive oxygen species (ROS). Herein, a strategy of Fenton reaction cycloacceleration initiated by remodeling the TME for magnetic resonance imaging (MRI)‐guided high‐performance ferroptosis therapy of tumors is proposed. The synthesized nanocomplex exhibits enhanced accumulation at carbonic anhydrase IX (CAIX)‐positive tumors based on the CAIX‐mediated active targeting, and increased acidification via the inhibition of CAIX by 4‐(2‐aminoethyl) benzene sulfonamide (ABS) (remodeling TME). This accumulated H+ and abundant glutathione in TME synergistically trigger biodegradation of the nanocomplex to release the loaded cuprous oxide nanodots (CON), β‐lapachon (LAP), Fe3+, and gallic acid‐ferric ions coordination networks (GF). The Fenton and Fenton‐like reactions are cycloaccelerated via the catalytic loop of Fe‐Cu, and the LAP‐triggered and nicotinamide adenine dinucleotide phosphate quinone oxidoreductase1‐mediated redox cycle, generating robust ROS and plenitudinous lipid peroxides accumulation for ferroptosis of tumor cells. The detached GF network has improved relaxivities in response to the TME. Therefore, the strategy of Fenton reaction cycloacceleration initiated by remodeling the TME is promising for MRI‐guided high‐performance ferroptosis therapy of tumors.
Environmentally Adaptable Organo–Ionic Gel‐Based Electrodes for Real‐Time On‐Skin Electrocardiography Monitoring
Authors: Tang Shuaimin , Sha Dongyong , He Zirui , Chen Xi , Ma Yifan , Liu Changsheng , Yuan Yuan 
Published: March 2023

AbstractOn‐skin personal electrocardiography (ECG) devices, which can monitor real‐time cardiac autonomic changes, have been widely applied to predict cardiac diseases and save lives. However, current interface electrodes fail to be unconditionally and universally applicable, often losing their efficiency and functionality under harsh atmospheric conditions (e.g., underwater, abnormal temperature, and humidity). Herein, an environmentally adaptable organo–ionic gel‐based electrode (OIGE) is developed with a facile one‐pot synthesis of highly conductive choline‐based ionic liquid ([DMAEA‐Q] [TFSI], I.L.) and monomers (2,2,2‐trifluoroethyl acrylate (TFEA) and N‐hydroxyethyl acrylamide (HEAA). In virtue of inherent conductivity, self‐responsive hydrophobic barriers, dual‐solvent effect, and multiple interfacial interactions, this OIGE features distinct sweat and water‐resistance, anti‐freezing and anti‐dehydration properties with strong adhesiveness and electrical stability under all kinds of circumstances. In contrast to the dysfunction of commercial gel electrodes (CGEs), this OIGE with stronger adhesion as well as skin tolerability can realize a real‐time and accurate collection of ECG signals under multiple extreme conditions, including aquatic environments (sweat and underwater), cryogenic (<−20°C) and arid (dehydration) environments. Therefore, the OIGE shows great prospects in diagnosing cardiovascular diseases and paves new horizons for multi‐harsh environmental personalized healthcare.