bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presenting a united front at the dinner table: The case of merged speakership and merged recipiency
Authors: Waring Hansun Zhang 
Published: July 2023

Abstract
The importance of presenting a united front has long since been an integral part of parenting advice. Despite the wealth of productive research on parent-child interaction, we have very little knowledge of how such a united front is assembled in situ, In the meantime, although few would question the benefit of collaboration, we are still in the process of understanding how collaboration is carried out in the micro-moments of interaction. This article contributes to the growing literature on parent-child interaction as well as that on collaboration in interaction by detailing how two parents achieve collaboration through merged speakership and merged recipiency. Findings may be applicable to a wide range of workspaces beyond the domestic sphere. (Family interaction, conversation analysis, collaboration)*
A first exploration of the economic consequences of an autonomous surgical robot for lateral skull base surgery: an early health technology assessment
Authors: Nabuurs Cindy H. , Kievit Wietske , Haegens Lex , Grutters Janneke P.C. , Kunst Henricus P.M. 
Published: July 2023

Abstract

Objectives
Lateral skull base procedures, such as translabyrinthine approach (TLA), are challenging. An autonomous surgical robot might be a solution to these challenges. Our aim is to explore in an early phase the economic consequences of an autonomous surgical robot compared with conventional TLA.

Methods
An early decision analytic model was constructed in order to perform a step-wise threshold analyses and a sensitivity analysis to analyze the impact of the several factors on the incremental costs.

Results
Using surgical robot results in incremental costs – EUR 5,562 per procedure – compared to conventional TLA. These costs are most reduced by higher number of procedures, followed by lower price of the robot, saved operation time, and reduced risk of complication, respectively.

Conclusions
The incremental costs of using an autonomous surgical robot can be decreased by choosing applications with a high turnover rate, a long operation time, and a high complication rate.
Measuring the development of lexical richness of L2 Spanish: A longitudinal learner corpus study
Authors: Díez-Ortega María , Kyle Kristopher 
Published: July 2023

AbstractResearch has indicated that lexical richness is an important indicator of second language (L2) proficiency. However, most research has examined written, cross-sectional English L2 corpora and does not necessarily indicate how spoken lexical use develops over time or whether observed trends are stable across L2s. This study adds to previous research on the development of spoken vocabulary by investigating lexical features of L2 Spanish learners over a 21-month period, using the LANGSNAP corpus. Multiple lexical richness indices used in previous studies were examined including lexical diversity, word frequency, word concreteness, and bigram strength of association. Linear mixed-effects models were run to examine changes over time. The results suggest that although some features of lexical richness (e.g., word frequency) see meaningful change over time, others (e.g., bigram T score) may not be indicative of L2 oral development.
A diagnostic model based on routine blood examination for serious bacterial infections in neonates–a cross-sectional study
Authors: Liang Runqiang , Chen Ziyu , Yang Shumei , Yang Jie , Wang Zhu , Lin Xin , Xu Fang 
Published: July 2023

Abstract
Routine blood examination is an easy way to examine infectious diseases. This study is aimed to develop a model to diagnose serious bacterial infections (SBI) in ICU neonates based on routine blood parameters. This was a cross-sectional study, and data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III). SBI was defined as suffering from one of the following: pyelonephritis, bacteraemia, bacterial meningitis, sepsis, pneumonia, cellulitis, and osteomyelitis. Variables with statistical significance in the univariate logistic regression analysis and log systemic immune–inflammatory index (SII) were used to develop the model. The area under the curve (AUC) was calculated to assess the performance of the model. A total of 1,880 participants were finally included for analysis. Weight, haemoglobin, mean corpuscular volume, white blood cell, monocyte, premature delivery, and log SII were selected to develop the model. The developed model showed a good performance to diagnose SBI for ICU neonates, with an AUC of 0.812 (95% confidence interval (CI): 0.737–0.888). A nomogram was developed to make this model visualise. In conclusion, our model based on routine blood parameters performed well in the diagnosis of neonatal SBI, which may be helpful for clinicians to improve treatment recommendations.
On the exponential growth rates of lattice animals and interfaces
Authors: Georgakopoulos Agelos , Panagiotis Christoforos 
Published: July 2023

AbstractWe introduce a formula for translating any upper bound on the percolation threshold of a lattice$G$into a lower bound on the exponential growth rate of lattice animals$a(G)$and vice versa. We exploit this in both directions. We obtain the rigorous lower bound${\dot{p}_c}({\mathbb{Z}}^3)\gt 0.2522$for 3-dimensional site percolation. We also improve on the best known asymptotic bounds on$a({\mathbb{Z}}^d)$as$d\to \infty$. Our formula remains valid if instead of lattice animals we enumerate certain subspecies called interfaces. Enumerating interfaces leads to functional duality formulas that are tightly connected to percolation and are not valid for lattice animals, as well as to strict inequalities for the percolation threshold.Incidentally, we prove that the rate of the exponential decay of the cluster size distribution of Bernoulli percolation is a continuous function of$p\in (0,1)$.
Anemia and Spaceflight Associated Neuro-Ocular Syndrome (SANS)
Authors: Waisberg Ethan , Ong Joshua , Masalkhi Mouayad , Lee Andrew G. 
Published: July 2023

AbstractSpaceflight associated neuro-ocular syndrome (SANS) is a collection of distinct findings seen in some astronauts following prolonged spaceflight and is characterized by: optic disc edema, globe flattening, and choroidal folds. In this manuscript, we describe the potential mechanisms linking anemia and SANS. Future research aimed at understanding the relationship between these conditions may help to develop countermeasures and mitigation efforts for SANS.
Quality of prescription writing in Brazilian primary health care
Authors: Batista Almária Mariz , Gama Zenewton André da Silva , Hernández Pedro Jesús Saturno , Souza Dyego 
Published: July 2023

Abstract

Objective:
To evaluate the quality of prescription writing in the context of public primary health care.

Background:
Prescription errors are one of the leading patient safety problems in primary care and can be caused by errors in therapeutic decisions or in the quality of prescription writing.

Methods:
Cross-sectional observational study conducted in a municipality in Northeastern Brazil. The assessment instrument (including 13 indicators and one composite indicator) was applied to a representative sample of drug prescriptions from the 24 Family Health Teams providing Primary Health Care in the municipality, dispensed in January 2021. Estimates of compliance and their 95% confidence intervals and graphical analysis of frequencies are assessed globally and stratified by dispensing units and prescribers.

Findings:
The average composite prescription writing quality on a 0-100 scale was 60.2 (95% CI 57.8–62.6). No quality criteria had 100% compliance. The highest compliance rates were found for ‘frequency of administration’ (98.9%) and ‘identification of the prescriber’ (98.9%). On the other hand, ‘recorded information on allergy’ (0.0%), ‘patient’s date of birth’ (1.7%), ‘nonpharmacological recommendations’ (1.7%), and ‘guidance on the use of the drug’ (25%) were the indicators with lower compliance, contributing to 69% of the noncompliances found. The type and frequency of the errors in the quality of prescription writing uncovered in this study confirm the continuing need to tackle this problem to improve patient safety. The results identify priority aspects for interventions and further studies on the quality of prescription writing in the context of Primary Health Care in Brazil.
How Should Diverse Stakeholder Interests Shape Evaluations of Complex Water Resources Systems Robustness When Confronting Deeply Uncertain Changes?
Authors: Sunkara Sai Veena , Singh Riddhi , Gold David , Reed Patrick , Bhave Ajay 
Published: July 2023

AbstractRobustness analysis can support the design and operation of large‐scale water infrastructure projects confronting deeply uncertain futures. However, diverse actors, contextual specificities, sectoral interests, and risk attitudes make it difficult to identify an appropriate robustness metric to rank decision alternatives under deep uncertainty. Here, we clarify how methodological choices affect robustness evaluation using the multi‐actor, multi‐sector Inchampalli‐Nagarjuna Sagar water transfer megaproject in Southern India. We compare a suite of water transfer strategies discovered using evolutionary multi‐objective direct policy search (EMODPS), a strategy proposed by regional authorities and the status quo of no water transfer. We stress‐test these strategies across scenarios that capture climatic and socioeconomic uncertainties and rank them using robustness metrics representing sectoral perspectives and priorities of different actors with varying risk attitudes. Results show a considerable impact of metric choices on robustness rankings of strategies, with compromise solution discovered via EMODPS as robust. The no‐transfer strategy results in the worst water supply robustness with an average volumetric deficit of 17% of total historical demands but emerges as a robust alternative for 6 out of 12 combinations of actor‐sectors with high risk aversion. Also, changes in the amplitude of the Indian Summer Monsoon is identified as the most important uncertain factor determining the failure of strategies. Our findings highlight that the selection of robust solutions should be guided by an understanding of how assumed risk attitudes shape stakeholders' perceptions of vulnerabilities. These findings are generalizable to large infrastructure projects with diverse stakeholders and multisectoral impacts.
Biodiversity and Stoichiometric Plasticity Increase Pico‐Phytoplankton Contributions to Marine Net Primary Productivity and the Biological Pump
Authors: Letscher Robert T. , Moore J. Keith , Martiny Adam C. , Lomas Michael W. 
Published: July 2023

AbstractEarth System Models generally predict increasing upper ocean stratification from 21st century warming, which will cause a decrease in the vertical nutrient flux forcing declines in marine net primary productivity (NPP) and carbon export. Recent advances in quantifying marine ecosystem carbon to nutrient stoichiometry have identified large latitudinal and biome variability, with low‐latitude oligotrophic systems harboring pico‐sized phytoplankton exhibiting large phosphorus to carbon cellular plasticity. The climate forced changes in nutrient flux stoichiometry and phytoplankton community composition are thus likely to alter the ocean's biogeochemical response and feedback with the carbon‐climate system. We have added three pico‐phytoplankton functional types within the Biogeochemical Elemental Cycling component of the Community Earth System Model while incorporating variable cellular phosphorus to carbon stoichiometry for all represented phytoplankton types. The model simulates Prochlorococcus and Synechococcus populations that dominate the productivity and sinking carbon export of the tropical and subtropical ocean, and pico‐eukaryote populations that contribute significantly to productivity and export within the subtropical to mid‐latitude transition zone, with the western subtropical regions of each basin supporting the most P‐poor stoichiometries. Subtropical gyre recirculation regions along the poleward flanks of surface western boundary currents are identified as regional hotspots of enhanced carbon export exhibiting C‐rich/P‐poor stoichiometry, preferentially inhabited by pico‐eukaryotes and diatoms. Collectively, pico‐phytoplankton contribute ∼58% of global NPP and ∼46% of global particulate organic carbon export below 100 m through direct and ecosystem processing pathways. Biodiversity and cellular nutrient plasticity in marine pico‐phytoplankton combine to increase their contributions to ocean productivity and the biological carbon pump.
Thermally Significant Fluid Seepage Through Thick Sediment on the Juan de Fuca Plate Entering the Cascadia Subduction Zone
Authors: Norvell Benjamin , Kyritz Thomas , Spinelli Glenn A. , Harris Robert N. , Dickerson Kristin , Tréhu Anne M. , Carbotte Suzanne , Han Shuoshuo , Boston Brian , Lee Michelle ,   The CHINOoK Project Science Party
Published: July 2023

AbstractWe use heat flux measurements colocated with seismic reflection profiles over a buried basement high on the Juan de Fuca plate ∼25 km seaward of the deformation front offshore Oregon to test for the presence of hydrothermal circulation in the oceanic crust. We also revisit heat flux data crossing a buried basement high ∼25 km seaward of the deformation front ∼150 km north, offshore Washington. Seafloor heat flux is inversely correlated with sediment thickness, consistent with vigorous hydrothermal circulation in the basement aquifer homogenizing temperatures at the top of the basement. Heat flux immediately above the summit of the basement highs is greater than expected solely from conduction. Fluid seepage at rates of ∼2.6–5.4 cm yr−1in a 1–1.5 km‐wide conduit through ∼800–1,300 m thick sediment sections above these basement highs can explain these observations. Observations of thermally significant fluid seepage through sediment >225 m thick on oceanic crust are unprecedented. High sediment permeability, high fluid overpressure in the basement, or a combination of both is required to drive fluid seepage at the observed rates. We infer that rapid seepage occurs because the basement highs rise above the low permeability basal sediment with their tops protruding into the base of high permeability Nitinat or Astoria Fan sediment. Seepage from basement highs penetrating into the submarine fans can affect the thermal state of crust entering the subduction zone.
Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism
Authors: Britton Brooke M. , Yovanno Remy A. , Costa Sara F. , McCausland Joshua , Lau Albert Y. , Xiao Jie , Hensel Zach 
Published: July 2023

AbstractThe bacterial divisome is a macromolecular machine composed of more than 30 proteins that controls cell wall constriction during division. Here, we present a model of the structure and dynamics of the core complex of theE. colidivisome, supported by a combination of structure prediction, molecular dynamics simulation, single-molecule imaging, and mutagenesis. We focus on the septal cell wall synthase complex formed by FtsW and FtsI, and its regulators FtsQ, FtsL, FtsB, and FtsN. The results indicate extensive interactions in four regions in the periplasmic domains of the complex. FtsQ, FtsL, and FtsB support FtsI in an extended conformation, with the FtsI transpeptidase domain lifted away from the membrane through interactions among the C-terminal domains. FtsN binds between FtsI and FtsL in a region rich in residues with superfission (activating) and dominant negative (inhibitory) mutations. Mutagenesis experiments and simulations suggest that the essential domain of FtsN links FtsI and FtsL together, potentially modulating interactions between the anchor-loop of FtsI and the putative catalytic cavity of FtsW, thus suggesting a mechanism of how FtsN activates the cell wall synthesis activities of FtsW and FtsI.
Harnessing microcomb-based parallel chaos for random number generation and optical decision making
Authors: Shen Bitao , Shu Haowen , Xie Weiqiang , Chen Ruixuan , Liu Zhi , Ge Zhangfeng , Zhang Xuguang , Wang Yimeng , Zhang Yunhao , Cheng Buwen , Yu Shaohua , Chang Lin , Wang Xingjun 
Published: July 2023

AbstractOptical chaos is vital for various applications such as private communication, encryption, anti-interference sensing, and reinforcement learning. Chaotic microcombs have emerged as promising sources for generating massive optical chaos. However, their inter-channel correlation behavior remains elusive, limiting their potential for on-chip parallel chaotic systems with high throughput. In this study, we present massively parallel chaos based on chaotic microcombs and high-nonlinearity AlGaAsOI platforms. We demonstrate the feasibility of generating parallel chaotic signals with inter-channel correlation <0.04 and a high random number generation rate of 3.84 Tbps. We further show the application of our approach by demonstrating a 15-channel integrated random bit generator with a 20 Gbps channel rate using silicon photonic chips. Additionally, we achieved a scalable decision-making accelerator for up to 256-armed bandit problems. Our work opens new possibilities for chaos-based information processing systems using integrated photonics, and potentially can revolutionize the current architecture of communication, sensing and computations.
Localised surface plasmon resonance inducing cooperative Jahn–Teller effect for crystal phase-change in a nanocrystal
Authors: Sakamoto Masanori , Hada Masaki , Ota Wataru , Uesugi Fumihiko , Sato Tohru 
Published: July 2023

AbstractThe Jahn–Teller effect, a phase transition phenomenon involving the spontaneous breakdown of symmetry in molecules and crystals, causes important physical and chemical changes that affect various fields of science. In this study, we discovered that localised surface plasmon resonance (LSPR) induced the cooperative Jahn–Teller effect in covellite CuS nanocrystals (NCs), causing metastable displacive ion movements. Electron diffraction measurements under photo illumination, ultrafast time-resolved electron diffraction analyses, and theoretical calculations of semiconductive plasmonic CuS NCs showed that metastable displacive ion movements due to the LSPR-induced cooperative Jahn–Teller effect delayed the relaxation of LSPR in the microsecond region. Furthermore, the displacive ion movements caused photo-switching of the conductivity in CuS NC films at room temperature (22 °C), such as in transparent variable resistance infrared sensors. This study pushes the limits of plasmonics from tentative control of collective oscillation to metastable crystal structure manipulation.
Chemically programmed STING-activating nano-liposomal vesicles improve anticancer immunity
Authors: Chen Xiaona , Meng Fanchao , Xu Yiting , Li Tongyu , Chen Xiaolong , Wang Hangxiang 
Published: July 2023

AbstractThe often immune-suppressive tumor microenvironment (TME) may hinder immune evasion and response to checkpoint blockade therapies. Pharmacological activation of the STING pathway does create an immunologically hot TME, however, systemic delivery might lead to undesired off-target inflammatory responses. Here, we generate a small panel of esterase-activatable pro-drugs based on the structure of the non-nucleotide STING agonist MSA-2 that are subsequently stably incorporated into a liposomal vesicle for intravenous administration. The pharmacokinetic properties and immune stimulatory capacity of pro-drugs delivered via liposomes (SAProsomes) are enhanced compared to the free drug form. By performing efficacy screening among the SAProsomes incorporating different pro-drugs in syngeneic mouse tumor models, we find that superior therapeutic performance relies on improved delivery to the desired tumor and lymphoid compartments. The best candidate, SAProsome-3, highly stimulates secretion of inflammatory cytokines and creates a tumoricidal immune landscape. Notably, upon application to breast cancer or melanoma mouse models, SAProsome-3 elicits durable remission of established tumors and postsurgical tumor-free survival while decreasing metastatic burden without significant systemic toxicity. In summary, our work establishes the proof of principle for a better targeted and more efficient and safe STING agonist therapy.
Alvarez varifocal X-ray lens
Authors: Dhamgaye Vishal , Laundy David , Khosroabadi Hossein , Moxham Thomas , Baldock Sara , Fox Oliver , Sawhney Kawal 
Published: July 2023

AbstractVisible light optical elements such as lenses and mirrors have counterparts for X-rays. In the visible regime, a variable focusing power can be achieved by an Alvarez lens which consists of a pair of inline planar refractors with a cubic thickness profile. When the two refractors are laterally displaced in opposite directions, the parabolic component of the wavefront is changed resulting in a longitudinal displacement of the focus. This paper reports an implementation of this concept for X-rays using two planar microfabricated refractive elements. The Alvarez X-ray lens can vary the focal distance of an elliptical X-ray mirror or a planar compound X-ray lens over several millimetres. The study presents the first demonstration of an Alvarez X-ray lens which adaptively corrects defocus and astigmatism aberrations of X-ray optics. In addition, the Alvarez X-ray lens eliminates coma aberration in an elliptical mirror, to the lowest order, when combining the lens with an adjustment of the pitch angle of the mirror.
Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases
Authors: Stahn A. C. , Bucher D. , zu Eulenburg P. , Denise P. , Smith N. , Pagnini F. , White O. 
Published: July 2023

AbstractSpace exploration objectives will soon move from low Earth orbit to distant destinations like Moon and Mars. The present work provides an up-to-date roadmap that identifies critical research gaps related to human behavior and performance in altered gravity and space. The roadmap summarizes (1) key neurobehavioral challenges associated with spaceflight, (2) the need to consider sex as a biological variable, (3) the use of integrative omics technologies to elucidate mechanisms underlying changes in the brain and behavior, and (4) the importance of understanding the neural representation of gravity throughout the brain and its multisensory processing. We then highlight the need for a variety of target-specific countermeasures, and a personalized administration schedule as two critical strategies for mitigating potentially adverse effects of spaceflight on the central nervous system and performance. We conclude with a summary of key priorities for the roadmaps of current and future space programs and stress the importance of new collaborative strategies across agencies and researchers for fostering an integrative cross- and transdisciplinary approach from cells, molecules to neural circuits and cognitive performance. Finally, we highlight that space research in neurocognitive science goes beyond monitoring and mitigating risks in astronauts but could also have significant benefits for the population on Earth.