bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of small intestinal bacterial overgrowth in irritable bowel syndrome (IBS): Correlating H2 or CH4 production with severity of IBS
Authors: Onana Ndong Philippe , Boutallaka Hanae , Marine‐Barjoan Eugenia , Ouizeman Dann , Mroue Raja , Anty Rodolphe , Vanbiervliet Geoffroy , Piche Thierry 
Published: April 2023

AbstractBackground and AimThe prevalence and the role of small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome (IBS) remain unclear, as the literature provides heterogeneous information on the subject. The aim of this study was to determine the prevalence of SIBO in IBS and to assess the correlation between methane and hydrogen levels measured during breath tests and the severity of IBS.MethodTwo‐hundred and forty‐seven patients with IBS were prospectively included. A glucose breath test (GBT) measured H2 and CH4 production to diagnose SIBO. A test was positive when H2 values exceeded 12 ppm in the first 90 min and/or when a CH4 value exceeded 10 ppm at any time. IBS severity (IBS‐SSS), quality of life (GIQLI), and anxiety and depression (HAD) were assessed to investigate the correlation with H2 and CH4 production.ResultsThe prevalence of SIBO in IBS was 36.4% (9.7% with H2, 26.7% with CH4). CH4 levels were significantly higher in the predominantly constipated patients (P = 0.00), while H2 levels were significantly higher within the diarrheal phenotype (P = 0.01). IBS severity was not correlated with either H2 levels (r = 0.02; P = 0.84) or CH4 levels (r = 0.05; P = 0.64). H2 production was inversely correlated with the quality of life (r = −0.24; P = 0.03) and significantly correlated with the HAD scale (r = 0.22; P = 0.03). The pain and discomfort experienced during GBT was not correlated with methane levels (r = −0.09, P = 0.40), hydrogen levels (r = −0.01, P = 0.93), or sum of both (r = 0.06, P = 0.58), but significantly associated with IBS severity (r = 0.50, P <0.00).ConclusionSIBO has a high prevalence in IBS but does not increase its severity. Individual susceptibility to pain may have a greater influence on the severity of IBS.
Chironomid (Insecta: Chironomidae) community structure response to hydrological changes in the mid‐1950s in lake Nam Co, Tibetan Plateau
Authors: Echeverría‐Galindo Paula , Rigterink Sonja , Massaferro Julieta , Pérez Liseth , Wünnemann Bernd , Hoelzmann Philipp , Kang Wengang , Börner Nicole , Schwarz Anja , Laug Andreas , Peng Ping , Wang Junbo , Zhu Liping , Schwalb Antje 
Published: April 2023

ABSTRACTThe recent rise in air temperatures detected at high altitudes of the Tibetan Plateau has accelerated glacier melt and retreat. Moreover, enhanced monsoonal precipitation has increased runoff and transport of allochthonous material to the lakes. Consequently, water levels are rising, modifying the spatial distribution and composition of local aquatic biota. To infer these environmental and biological changes in recent decades, a 30‐cm‐long sediment core, representing the past ~160 years, from Nam Co, an endorheic lake, was analyzed for subfossil chironomid assemblages and sediment geochemistry. In total, 25 chironomid morphotypes were identified. Nineteen were considered as non‐rare taxa (abundances ≥2%) and six as rare taxa (abundances <2%). Since 1956 ce, higher chironomid richness (S = 19) is evident compared to the previous 100 years. The simultaneous decrease in the abundance of profundal Micropsectra radialis‐type and increase of both Chironomus and Procladius, taxa adapted to more eurytopic and slightly warmer water bodies, indicate increasing water temperatures and intensified primary productivity. The dominance of littoral chironomid assemblages reflects increasing lake water levels, flooded shorelines and expansion of littoral areas driven by increased precipitation and glacial meltwater input both resulting from the increase in air temperatures. This scenario is confirmed by increases in total nitrogen and Zr/Rb ratios, indicating higher productivity and coarser grain size as a consequence of increased runoff via the Niya Qu. These hydrological changes have resulted in a positive water balance that can be linked to an increase in moisture supply from the Indian summer monsoon and glacier melt, reflecting increasing temperatures and precipitation since 1956 ce, ultimately driven by anthropogenic warming.
Controllable crystal form transformation and temperature sensing properties studies of K3Sc0.5Lu0.5F6: Ho3+, Yb3+ with cryolite structure
Authors: Shuai Pengfei , Guo Qingfeng , Liao Libing , Yan Zhaoliang , Su Ke , Wang Yujia , Mei Lefu 
Published: April 2023

AbstractIn this work, a method for controllable regulation of crystal form was proposed for the first time and the effects of different crystal forms on the up‐conversion luminescence properties of Ho3+, Yb3+ co‐doped K3Sc0.5Lu0.5F6 (KSLF) phosphors was explored. KSLF:Ho3+, Yb3+ phosphors were synthesized by the high temperature solid‐state reaction method, and X‐ray diffraction (XRD) results illustrate that the compounds can obtain monoclinic phase and cubic phase at different synthesis temperatures. In addition, according to the power‐dependent up‐conversion luminescence (UCL) intensity, the UCL mechanism and the electronic transition process are discussed. Simultaneously, the temperature sensing behavior of the best samples with different crystal forms at different temperatures was studied by fluorescence intensity ratio technique. All the results show that KSLF:Ho3+, Yb3+ phosphors show great application potential in the field of temperature sensing, and the preparation of KSLF:Ho3+, Yb3+ in different crystal forms can provide a reference value for crystal design and growth.
Blue agave inulin‐soluble dietary fiber: effect on technological quality properties of pangasius mince emulsion‐type sausage
Authors: Sherpa Kusang , Priyadarshini Mocherla Bhargavi , Mehta Naresh Kumar , Waikhom Gusheinzed , Surasani Vijay Kumar Reddy , Tenali Diamond Rajakumar , Vaishnav Anand , Sharma Sanjeev , Debbarma Sourabh 
Published: April 2023

AbstractBACKGROUNDThe aim of the work was to investigate the influence of supplementing pangasius mince‐based emulsion sausages with blue agave‐derived inulin at 1% (T1), 2% (T2), 3% (T3), 4% (T4), and 5% (T5) on its technological quality attributes and acceptability.RESULTSThe cooking yield of T‐2, T‐3, and T‐4 sausages (96–97%) exhibited no significant difference (P > 0.05), which was higher than the other lots. The T‐2 batter exhibited a significant difference with all other treatments, showing the lowest total expressible fluid (12.20%) value, indicating the highest emulsion stability of the batter. There was a significant effect on the diameter reduction of the cooked sausages as the level of inulin increased. Sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed the proteolysis of raw mince without inulin and new bands in cooked sausage samples were observed. Increasing inulin content increased the hardness of the sausages from 2510.81 ± 114.31 g to 3415.54 ± 75.88. The differential scanning calorimetry melting temperatures of peak 2 of the T‐1, T‐2, T‐3, and T‐4 increased as the inulin content increased from 1 to 4%. The scanning electron microscope images exhibited a smooth appearance on the surface as the inulin level increased.CONCLUSIONThe sausages incorporated with the 2% and 3% blue agave plant‐derived inulin (T‐2 and T‐3) showed better sensory overall acceptability scores than the control. The results suggested that the blue agave plant‐derived inulin could be efficiently utilized at the 2% and 3% levels to enhance the quality of emulsion‐type pangasius sausage. © 2023 Society of Chemical Industry.
Postoperative inflammatory markers predict survival in patients after McKeown esophagectomy for esophageal cancer
Authors: Takahashi Keita , Masuda Takahiro , Ishikawa Yoshitaka , Tanishima Yuichiro , Kurogochi Takanori , Yuda Masami , Tanaka Yujiro , Matsumoto Akira , Yano Fumiaki , Eto Ken 
Published: April 2023

AbstractBackgroundPreoperative C‐reactive protein‐to‐albumin ratio (CAR) and neutrophil‐to‐lymphocyte ratio (NLR) are correlated with a poor prognosis of various cancers. The significance of postoperative systemic inflammation markers for prognostic stratification of patients with esophageal cancer (EC) has not been established. Therefore, this study aimed to elucidate the impact of postoperative CAR and NLR on survival in patients with EC for prognostic stratification.MethodsA total of 235 patients who received curative esophagectomy were analyzed. A Cox proportional hazard model was performed to detect prognostic factors.ResultsMultivariate analysis revealed that postoperative CAR ≥ 0.05 (hazard ratio [HR], 1.62; 95% confidence interval [CI], 1.01–2.57) and NLR ≥ 3.0 (HR, 2.81; 95% CI, 1.79–4.40) were independent prognostic factors for overall survival. Meanwhile, postoperative CAR ≥ 0.05 (HR, 1.61; 95% CI, 1.07–2.41) and NLR ≥ 3.0 (HR, 1.92; 95% CI, 1.29–2.85) were also significant prognostic factors for relapse‐free survival. In addition, the patient group with postoperative CAR ≥ 0.05 and NLR ≥ 3.0 had the worst survival.ConclusionsPostoperative CAR ≥ 0.05 and NLR ≥ 3.0 can predict the poor survival of patients who received curative esophagectomy for EC.
Toward 3D Integration of Highly See‐Through Photonic Circuits in Glass
Authors: Zhong Lijing , Wang Yuying , Tan Dezhi , Qiu Jianrong 
Published: April 2023

AbstractEmbedding naked‐eye‐invisible electronic and optical elements in transparent panels is at the heart of enabling mobile transparent accessories by making see‐through smart screens. Here, a novel invisible photonic element, highly see‐through (HST) waveguide, is reported, which is written by femtosecond laser in glass. A general synergistic control of the thermodynamic and dynamic behavior over the matter fluid in the laser irradiated confined region to tune the cross‐section of waveguides and suppress the generation of scattering centers in the waveguides is established. An effective reduction of light leakage (covering red, green, and blue coupled light) by an order of magnitude compared to conventional waveguides is achieved, making it highly see‐through at bright illumination of >100 lux. A general dynamical model based on a frozen‐in shock wave diffusion process is proposed, which is applicable to various glasses regardless of their compositions. Ultra‐wide tuning of HST waveguide mode diameters from 4.9 to 26.5 µm is demonstrated, making it versatile for functionalizing various transparent screens by mode‐matching with fiber sources and integrated planar waveguides of different working wavelengths.
A vertical DIM lidar for refractive index structure parameter profiles estimation in low‐layer atmosphere
Authors: Qiu Chenxiang , Wang Hao , Hou Zaihong , Jing Xu , He Feng , Zhang Silong 
Published: April 2023

AbstractThis Letter presents an experimental demonstration of a vertical differential image motion (DIM) lidar for calculating the profiles of the low‐layer atmospheric refractive index structure parameters. Utilizing the differences between weighting functions, we propose a convenient approach for the real‐time estimation of low‐layer profiles from DIM lidar data. This approach only requires returned fluxes as input, yet it has the intrinsic ability to capture real‐time turbulence profiles. Validations against the collected observational data have shown this approach to be computationally inexpensive. The long‐term comparisons with micro‐thermometers indicate that in such a way vertical DIM lidars can be used for providing not only a general assessment of turbulence effects along the measurement path but turbulence profiles.
Prostate lesions characterization using diffusion‐weighted spatiotemporal encoded MRI: Feasibility and initial assessment
Authors: Otikovs Martins , Portnoy Orith , Anaby Debbie , Rosenzweig Barak , Nissan Noam , Frydman Lucio 
Published: April 2023

PurposeTo assess the feasibility and reliability of a DWI protocol based on spatiotemporally encoding (SPEN), to target prostate lesions along guidelines normally used in EPI‐based DWI clinical practice.MethodsProstate Imaging—Reporting and Data System recommendations underlying clinical prostate scans were used to develop a SPEN‐based DWI protocol, which included a novel, local, low‐rank regularization algorithm. These DWI acquisitions were run at 3 T under similar nominal spatial resolutions and diffusion‐weighting b‐values as used in EPI‐based clinical studies. Prostates of 11 patients suspected of clinically significant prostate cancer lesions were therefore scanned using the two methods, with the same number of slices, same slice thickness, and same interslice gaps.ResultsOf the 11 patients scanned, SPEN and EPI provided comparable information in 7 of the cases, whereas EPI was deemed superior in a case for which SPEN images had to be acquired with a shorter effective TR owing to scan‐time constraints. SPEN provided reduced susceptibility to field‐derived distortions in 3 of the cases.ConclusionsSPEN's ability to provide prostate lesion contrast was most clearly evidenced for DW images acquired with b ≥ 900 s/mm2. SPEN also succeeded in decreasing occasional image distortions in regions close to the rectum, affected by field inhomogeneities. EPI advantages arose when using short effective TRs, a regime in which SPEN‐based DWI was handicapped by its use of nonselective spin inversions, leading to the onset of an additional T1 weighting.
Coping in times of disruption and deprivation—Experiences of family members during COVID‐19 patients' critical illness: A qualitative study
Authors: Berntzen Helene , Lind Ranveig , Alfheim Hanne , Tøien Kirsti 
Published: April 2023

AbstractAimTo explore the experiences and needs of family members during the course of COVID‐19 critical illness from onset to rehabilitation.DesignAn exploratory qualitative study.MethodsTwelve family members of surviving critically ill COVID‐19 patients and restricted from visiting the patients, were interviewed digitally. Reflexive thematic analysis was used.ResultsThree themes were generated from the data; ‘Experiencing a double burden’, ‘Becoming an insignificant other’ and ‘Regaining significance’. Family members were often ill themselves, which represented an extra burden when the patient deteriorated. From admission, the family members became bystanders, deprived of most contact with the patients, as communication and information from the intensive care unit appeared unstructured and haphazard. However, when patients were discharged, great responsibility was placed on the family members.
Relationships among nurse managers' job design, work environment, and nurse and patient outcomes
Authors: Grandfield Elizabeth M. , Schlotzhauer Ann E. , Cramer Emily , Warshawsky Nora E. 
Published: April 2023

AbstractThe importance of nurse managers' practice environments in affecting outcomes for direct care nurses and patients has been well‐researched. Nonetheless, much remains to be learned about the determinants of the nurse manager practice environment. In this study, 541 US nurse managers' survey responses were matched to unit‐level aggregate data of their subordinates' responses on the National Database of Nursing Quality Indicators. A model relating job design and experience to the nurse manager's practice environment and direct care nurse (i.e., job satisfaction, intent to stay, and joy and meaning in work) and patient outcomes (i.e., nurse‐reported quality of care and missed nursing care) was evaluated through multilevel path analysis. Nurse manager span of control, support staff, and experience influence nurse managers' perceptions of their practice environment and nurse and patient outcomes. Although support staff can offset some negative effects of wide spans of control, it does not fully compensate for wide spans. Thus, nurse manager job design factors and experience relate to nurse manager practice environments and valued downstream outcomes. The present research emphasizes the importance of a positive nurse manager practice environment and provides guidance for nurse manager hiring and job design decisions.
Evaluation of integrated diabetes and mental health care for type 1 diabetes and disordered eating (T1DE): the ComPASSION service
Authors: Wild Daisy , Kerr Marion , Figueiredo Carla , Partridge Helen 
Published: April 2023

AbstractType 1 diabetes and disordered eating (T1DE) is often poorly understood and treatment is inadequate in many cases, with little or no co‐ordination between physical and mental health teams. In 2019, NHS England launched two pilot programmes to increase understanding of T1DE, and to trial an integrated diabetes and mental health pathway for assessment, referral and treatment. This paper sets out key findings from the independent evaluation of one of these pilots, the ComPASSION service in Wessex, including baseline patient characteristics, clinical outcomes, and patient and staff experience. Among 11 patients with at least 12 months follow‐up, the median change in HbA1c was a reduction of 31mmol/mol. Copyright © 2023 John Wiley & Sons.
Teplizumab – preventative approaches to type 1 diabetes mellitus
Authors: Seewoodhary Jason , Silveira Angela 
Published: April 2023

AbstractImmunotherapies offer the potential to reprogramme the immune system to halt autoimmune destruction of insulin‐producing β‐cells within the pancreas, dealing with the root cause of type 1 diabetes (T1DM) for the first time. Leading on from this, teplizumab, the first drug in this class, has been found to delay the onset of T1DM by an average of three years in people stratified high risk for developing T1DM. This review will critically consider the evidence basis underlying the utility of teplizumab in the management of T1DM. Copyright © 2023 John Wiley & Sons.
Using pooled electronic health records data to conduct pharmacoepidemiology safety studies: Challenges and lessons learned
Authors: Beukelman Timothy , Chen Lang , Annapureddy Narender , Oates Jim , Clowse Megan E. B. , Long Millie , Kappelman Michael D. , Rhee Rennie L. , Merkel Peter A. , Nowell William Benjamin , Xie Fenglong , Clinton Cassie , Curtis Jeffrey R. 
Published: April 2023

AbstractPurposeWe assessed the suitability of pooled electronic health record (EHR) data from clinical research networks (CRNs) of the patient‐centered outcomes research network to conduct studies of the association between tumor necrosis factor inhibitors (TNFi) and infections.MethodsEHR data from patients with one of seven autoimmune diseases were obtained from three CRNs and pooled. Person‐level linkage of CRN data and Centers for Medicare and Medicaid Services (CMS) fee‐for‐service claims data was performed where possible. Using filled prescriptions from CMS claims data as the gold standard, we assessed the misclassification of EHR‐based new (incident) user definitions. Among new users of TNFi, we assessed subsequent rates of hospitalized infection in EHR and CMS data.ResultsThe study included 45 483 new users of TNFi, of whom 1416 were successfully linked to their CMS claims. Overall, 44% of new EHR TNFi prescriptions were not associated with medication claims. Our most specific new user definition had a misclassification rate of 3.5%–16.4% for prevalent use, depending on the medication. Greater than 80% of CRN prescriptions had either zero refills or missing refill data. Compared to using EHR data alone, there was a 2‐ to 8‐fold increase in hospitalized infection rates when CMS claims data were added to the analysis.ConclusionsEHR data substantially misclassified TNFi exposure and underestimated the incidence of hospitalized infections compared to claims data. EHR‐based new user definitions were reasonably accurate. Overall, using CRN data for pharmacoepidemiology studies is challenging, especially for biologics, and would benefit from supplementation by other sources.
Measurement and analysis of truck vibration levels in logistic Spain distribution to simulate package testing
Authors: Garrido Marta , Esteban Laura , Navarro Patricia , Herranz Nuria , Zabaleta Francisco Javier , Rouillard Vincent 
Published: April 2023

AbstractThe aim of this study was to measure the vibration levels in one of the types of truck most used in Spain for the shipment of packaged goods, formed by tractor unit and air‐suspension semi‐trailer with 26 tonnes (26 000 kg) payload capacity, considering the most representative routes of the main Spanish road network. The data presented in this study will enable the development of new specific vibration tests and will help product and package engineers to reduce damage in transit. In this study, 30 transport routes recording nearly 10 000 km of the Spanish main road network have been selected and analysed, and power spectral density (PSD) profiles are provided to simulate truck transport in Spain using random vibration test methods. The resulting PSD profiles were established by generating two grms levels (0.21 and 0.15) obtaining the highest intensity from the calculation of the upper one‐sided normal tolerance limit (NTL) (30,95,50) and an average intensity profile at −6 dB with respect to the calculated NTL curve, which represents 70% of the lowest grms values of the study. This study uses NTL analysis to explore the vibration characteristics of a typical heavy goods transport vehicle type for various routes along main highways in Spain and propose new transport simulation test protocols dedicated to the Spanish main road distribution environment.
A review of experimental techniques for erectile function researches and development of medical technology using animal erectile dysfunction models in sexual and reproductive medicine
Authors: Kataoka Tomoya , Hotta Yuji , Kimura Kazunori 
Published: April 2023

AbstractBackgroundErectile dysfunction (ED) is one of the causes of male infertility and is a disease that requires treatment. The first‐line drugs for ED are phosphodiesterase 5 (PDE‐5) inhibitors, and further treatment options are currently limited. Medical technologies, such as genetic control and regenerative medicine, are developing rapidly. Research on erectile function is progressing rapidly, coupled with technological innovations in other areas.MethodsA PubMed search using the keywords “animal (rat, mouse, rabbit, dog, and monkey)” and “erectile” was conducted, and all relevant peer‐reviewed English results were evaluated.Main findingsThe methods for evaluating erectile function include intracavernous pressure (ICP) measurements, isometric tension studies, and dynamic infusion cavernosometry. Papers also reported various disease model animals for the study of diabetes mellitus, cavernous nerve injury, and drug‐induced ED.ConclusionBasic research on ED treatment has progressed rapidly over the past 20 years. In particular, research on the mechanism of ED has been accelerated by the publication of a study on the evaluation of erectile function using ICP measurements in rats. In addition, molecular biological experimental methods such as polymerase chain reaction (PCR) and western blotting have become relatively easy to perform due to technological progress, thus advancing research development.