bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance enhancement of duobinary modulation-based DWDM system using particle swarm optimization
Authors: Singh Kuldeep , Arya Sandeep K. , Kumar Vinod 
Published: January 2023

Abstract
The next-generation light wave communication DWDM networks can accommodate large number of channels to efficiently utilize the bandwidth (BW). However, in the deployment of DWDM system mixing of two or more waves limits the performance due to four wave mixing (FWM) nonlinearity in fiber. This article, presents improved performance analysis of DWDM using a proposed improved duobinary modulation (IDBM), modified duobinary modulation (MDBM) and duobinary modulation (DBM) model for mitigation of FWM nonlinearities has been estimated experimentally through interference of noise on optical signal, FWM efficiency, FWM power etc. In IDBM, a unit delay in addition to time delay parameter is also utilized for generation of electrical duobinary pulses. The parameters of both delay blocks are tuned through particle swarm optimization (PSO) technique to improve the performance. The overall proposed IDBM effectively decreases the FWM. The results obtained for IDBM in terms of Q-factor 8.9, OSNR 18 dB, FWM power −87 dBm and FWM efficiency −70 dB shows substantial improvement with the recommended IDBM technique in comparison to DBM and MDBM schemes.
Tunable replica symmetry breaking in random laser
Authors: Xia Jiangying , Zhang Xiaojuan , Zhou Kaiming , Zhang Lin , Wang Erlei , Du Wenyu , Ma Jiajun , Li Siqi , Xie Kang , Yu Benli , Zhang Junxi , Hu Zhijia 
Published: January 2023

Abstract
Replica symmetry breaking (RSB) has been widely recognized as a statistical analysis approach to understand the disorder and nonlinear interactions in complex systems ranging from atoms to the cosmic scale. However, it is challenging to analyze the nonlinear optical characteristics of random laser (RL) in disordered gain medium via RSB due to the lack of a general RSB-based statistical analysis framework. In this work, we report the tunable RSB in polymer fiber RL, where the effects of temperature and different structures on RSB are investigated experimentally and theoretically. It experimentally proves that RSB in RL is not robust, and disorder and temperature are responsible for tunable RSB in RL, which contributes to the improvement of the statistical analysis framework for investigating the optical principles of RL using RSB. And the finding of the tunable RSB allows to investigate the dynamical differences for various RL systems, which broadens the directions for the use of spin-glass theory to explore the physical mechanism of RL.
Analytical chemistry of engineered nanomaterials: Part 1. Scope, regulation, legislation, and metrology (IUPAC Technical Report)
Authors: Labuda Jan , Barek Jiří , Gajdosechova Zuzana , Goenaga-Infante Heidi , Johnston Linda J. , Mester Zoltan , Shtykov Sergei 
Published: January 2023

Abstract
Analytical chemistry is crucial for understanding the complex behavior observed for engineered nanomaterials (ENMs). A variety of analytical chemistry techniques and methodological approaches are used for isolation/purification and determination of the composition of pristine nanomaterials and for the detection, identification, and quantification of nanomaterials in nano-enabled consumer products and the complex matrices found in cosmetics, food, and environmental and biological samples. Adequate characterization of ENMs also requires physicochemical characterization of number of other properties, including size, shape, and structure. The requirement for assessment of a number of ENM properties frequently requires interdisciplinary approaches and multi-modal analysis methods. This technical report starts with an overview of ENMs definitions and classification, their properties, and analytical scenarios encountered with the analysis of both pristine nanomaterials and complex matrices containing different nanomaterials. An evaluation of the current status regarding nanomaterial identification and characterization for regulatory purposes and legislation, including emerging regulations and related scientific opinions, is provided. The technical report also presents a large and critical overview of the metrology of nanomaterials, including available reference materials and the development and validation of standardized methods that are currently available to address characterization and analysis challenges. The report focuses mainly on chemical analysis techniques and thus it is complementary to previous IUPAC technical reports focused on characterizing the physical parameters of ENMs and on nanotoxicology.
Which ROMs Lead to Rome? A Systematic Review of the Effects of Range of Motion on Muscle Hypertrophy
Authors: Kassiano Witalo , Costa Bruna , Nunes João Pedro , Ribeiro Alex S. , Schoenfeld Brad J. , Cyrino Edilson S. 
Published: January 2023

Abstract
Kassiano, W, Costa, B, Nunes, JP, Ribeiro, AS, Schoenfeld, BJ, and Cyrino, ES. Which ROMs lead to Rome? a systematic review of the effects of range of motion on muscle hypertrophy. J Strength Cond Res XX(X): 000–000, 2022—Resistance exercise range of motion (ROM) influences muscular adaptations. However, there are no consistent practical guidelines about the optimal ROM for maximizing muscle hypertrophy. The objective of this article was to systematically review the literature for studies that compared the effects of full ROM (fROM) and partial ROM (pROM) on muscle hypertrophy. PubMed/MEDLINE, Scopus, and Web of Science databases were searched to identify articles from the earliest record up to and including April 2022. We calculated the effect size (ES) scores of the variables of interest. Eleven studies were included in the review. Full ROM and pROM performed in the initial part of the ROM elicited greater muscle hypertrophy of the rectus femoris, vastus lateralis, biceps brachii, and brachialis distal sites (between-groups ES: 0.20–0.90) than pROM performed in the final part of the ROM. fROM elicited greater muscle growth on the gluteus maximus and adductors than pROM in the final part of the ROM (between-groups ES: 0.24–0.25). Initial pROM produced more favorable proximal rectus femoris hypertrophy than fROM (between-groups ES: 0.35–0.38). pROM in the middle part of the ROM elicited greater triceps brachii hypertrophy than fROM (between-group ES: 1.21). In conclusion, evidence suggests that when training at a longer muscle length—through either pROM or fROM—some muscles, such as quadriceps femoris, biceps brachii, and triceps brachii, tend to experience optimal growth. Thus, the use pROM in the initial part of the excursion in combination with fROM training should be considered when prescribing hypertrophy-oriented resistance training programs.
Development and validation of RP HPLC method for the estimation of methyl paraben sodium and propyl paraben sodium in iron protein succinylate syrup
Authors: Javed Muhammad Faisal , Zahra Manzar , Javed Iqra , Ahmad Shahbaz , Jabeen Tayyaba , Ahmad Muhammad 
Published: January 2023

AbstractA new precise, selective and reliable reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for the determination of Methyl paraben sodium (MPS) and Propyl paraben sodium (PPS) (preservatives) in Iron protein succinylate syrup. Optimized conditions were; Methanol: Water (65: 35) as mobile phase, UV/Vis detector at the wavelength of 254 nm and flow rate was set at 1.3 ml min−1. By applying the set of conditions, separation of components was carried out in less than 7 min for both the analytes. The method was validated according to International conference of Harmonization (ICH) guidelines and the analytical characteristic parameters of validation included specificity, limit of detection (LOD), limit of quantification, linearity, accuracy, precision and robustness were evaluated. The calibration curve was found to be linear in the range of 0.045 mg mL−1 to 0.075 mg mL−1 for Methyl paraben sodium and 0.015 mg mL−1 to 0.025 mg mL−1 for propyl paraben sodium with a correlation coefficient r2 > 0.999. Accuracy; reported as percentage recovery was found to be in the range of 98.71%–101.64% for Methyl paraben sodium and 99.85%–101.47% for Propyl paraben sodium at 80%, 100% and 120% concentration for both the analytes. The proposed method was found to be precise and robust when evaluated by variations in wavelength, mobile phase composition, temperature and analyst. The limit of detection (LOD) was found 0.001 mg mL−1 (3 ppm) for Methyl paraben sodium and 0.001 mg mL−1 (1 ppm) for Propyl paraben sodium.
Hypoxia-Inducible Factor 2α Attenuates Renal Ischemia-Reperfusion Injury by Suppressing CD36-Mediated Lipid Accumulation in Dendritic Cells in a Mouse Model
Authors: Qu Junwen , Li Dawei , Jin Jingsi , Sun Nan , Wu Jiajin , Yang Chao , Wu Lingling , Zhuang Shaoyong , Wu Haoyu , Chen Ruoyang , Ren Yaofei , Zhong Chen , Ying Liang , Zhang Yan , Yuan Xiaodong , Zhang Ming 
Published: January 2023

Significance Statement
Hypoxia is a hallmark of renal ischemia-reperfusion injury (IRI) and serves as an essential regulator of innate immune responses during this process, although the mechanisms of this regulation remain unclear. Here, we showed in a murine model that HIF-2α knockout in dendritic cells (DCs) exacerbated renal IRI through activation of natural killer T cells. Mechanistically, HIF-2α deficiency upregulated CD36 expression of DCs, leading to cellular lipid accumulation. Pharmacologic inhibition of CD36 in DCs resulted in renoprotection by reducing lipid content and suppressing natural killer T cell activation. Our study strongly suggests that targeting the HIF-2α/CD36 regulatory axis may be a strategy for alleviating renal IRI.

Background
Hypoxia and hypoxia-inducible factors (HIFs) play essential and multiple roles in renal ischemia-reperfusion injury (IRI). Dendritic cells (DCs) comprise a major subpopulation of the immunocytes in the kidney and are key initiators and effectors of the innate immune responses after IRI. The role of HIF-2α in DCs remains unclear in the context of renal IRI.

Methods
To investigate the importance of HIF-2α in DCs upon renal IRI, we examined the effects of DC-specific HIF-2α ablation in a murine model. Bone marrow–derived DCs (BMDCs) from DC-specific HIF-2α–ablated mice and wild-type mice were used for functional studies and transcriptional profiling.

Results
DC-specific ablation of HIF-2α led to hyperactivation of natural killer T (NKT) cells, ultimately exacerbating murine renal IRI. HIF-2α deficiency in DCs triggered IFN-γ and IL-4 production in NKT cells, along with upregulation of type I IFN and chemokine responses that were critical for NKT cell activation. Mechanistically, loss of HIF-2α in DCs promoted their expression of CD36, a scavenger receptor for lipid uptake, increasing cellular lipid accumulation. Furthermore, HIF-2α bound directly to a reverse hypoxia-responsive element (rHRE) in the CD36 promoter. Importantly, CD36 blockade by sulfo-N-succinimidyl oleate (SSO) reduced NKT cell activation and abolished the exacerbation of renal IRI elicited by HIF-2α knockout.

Conclusions
Our study reveals a previously unrecognized role of the HIF-2α/CD36 regulatory axis in rewiring DC lipid metabolism under IRI-associated hypoxia. These findings suggest a potential therapeutic target to resolve long-standing obstacles in treatment of this severe complication.
Membranous Nephropathy in Syphilis is Associated with Neuron-Derived Neurotrophic Factor
Authors: Sethi Sanjeev , Madden Benjamin , Casal Moura Marta , Singh Raman Deep , Nasr Samih H. , Hou Jean , Sharma Alok , Nath Karl A. , Specks Ulrich , Fervenza Fernando C. , Haas Mark 
Published: January 2023

Significance Statement
Syphilis is a common worldwide sexually transmitted infection. Proteinuria may occur in patients with syphilis. Membranous nephropathy (MN) is the most common cause of proteinuria in syphilis. The target antigen of MN in syphilis is unknown. This study shows that MN in syphilis is associated with a novel target antigen called neuron-derived neurotrophic factor (NDNF). NDNF-associated MN has distinctive clinical and pathologic manifestations and NDNF appears to be the target antigen in syphilis-associated MN.

Background
Syphilis is a common sexually transmitted infection. Membranous nephropathy (MN) is a common cause of proteinuria in syphilis. The target antigen is not known in most cases of syphilis-associated MN.

Methods
We performed laser microdissection of glomeruli and mass spectrometry (MS/MS) in 250 cases (discovery cohort) of phospholipase A2 receptor–negative MN to identify novel target antigens. This was followed by immunohistochemistry/confocal microscopy to localize the target antigen along the glomerular basement membrane (GBM). Western blot analyses using IgG eluted from frozen biopsy tissue were performed to detect binding to target antigen.

Results
MS/MS studies of the discovery cohort revealed high total spectral counts of a novel protein, neuron-derived neurotrophic factor (NDNF), in three patients: one each with syphilis and hepatitis B, HIV (syphilis status not known), and lung tumor. Next, MS/MS studies of five cases of syphilis-MN (validation cohort) confirmed high total spectral counts of NDNF (average 45±20.4) in all (100%) cases. MS/MS of 14 cases of hepatitis B were negative for NDNF. All eight cases of NDNF-associated MN were negative for known MN antigens. Electron microscopy showed stage I MN in all cases, with superficial and hump-like deposits without GBM reaction. IgG1 was the dominant IgG subtype on MS/MS and immunofluorescence microscopy. Immunohistochemistry/confocal microscopy showed granular staining and colocalization of NDNF and IgG along GBM. Western blot analyses using eluate IgG of NDNF-MN showed binding to both nonreduced and reduced NDNF, while IgG eluate from phospholipase A2 receptor-MN showed no binding.

Conclusion
NDNF is a novel antigenic target in syphilis-associated MN.
Intensive BP Control in Patients with CKD and Risk for Adverse Outcomes
Authors: Ku Elaine , McCulloch Charles E. , Inker Lesley A. , Tighiouart Hocine , Schaefer Franz , Wühl Elke , Ruggenenti Piero , Remuzzi Giuseppe , Grimes Barbara A. , Sarnak Mark J. 
Published: January 2023

Background
The effect of intensive BP lowering (to systolic BP of <120 mm Hg) on the risk of kidney failure requiring KRT remains unclear in patients with advanced CKD. Such patients were not well-represented in trials evaluating intensive BP control.

Methods
To examine the effect of intensive BP lowering on KRT risk—or when not possible, trial-defined kidney outcomes—we pooled individual-level data from seven trials that included patients with eGFR<60 ml/min per 1.73 m2. We performed prespecified subgroup analyses to evaluate the effect of intensive BP control by baseline albuminuria and eGFR (CKD stages 4–5 versus stage 3).

Results
Of 5823 trial participants, 526 developed the kidney outcome and 382 died. Overall, intensive (versus usual) BP control was associated with a lower risk of kidney outcome and death in unadjusted analyses but these findings did not achieve statistical significance. However, the intervention's effect on the kidney outcome differed depending on baseline eGFR (P interaction=0.05). By intention-to-treat analysis, intensive (versus usual) BP control was associated with a 20% lower risk of the primary kidney outcome in those with CKD GFR stages 4–5, but not in CKD GFR stage 3. There was no interaction between intensive BP control and the severity of albuminuria for kidney outcomes.

Conclusions
Data from this pooled analysis of seven trials suggest a benefit of intensive BP control in delaying KRT onset in patients with stages 4–5 CKD but not necessarily with stage 3 CKD. These findings suggest no evidence of harm from intensive BP control, but also point to the need for future trials of BP targets focused on populations with advanced kidney disease.
El tratamiento científico de la jurisprudencia. Modelos de análisis jurisprudencial
Authors: Cifuentes Sandoval Germán , Mantilla Luz Stella , Rodríguez Suárez Ingrid Vanessa , Valencia Pachón Dayahana 
Published: January 2023

La jurisprudencia en Colombia es una fuente auxiliar de derecho, tal como lo consagra el artículo 230 de la Constitución Política de 1991, convirtiéndose en un factor fundamental mediante el cual toda clase de juristas intentan entender el espíritu judicial. Es así que de una sentencia puede resultar un resumen, comentario o análisis; siendo sumamente necesario conocer los diferentes modelos de análisis jurisprudencial que se manejan, resaltando la metodología propuesta por el profesor Diego López Medina (2006), en su obra El derecho de los jueces, que permite clasificar las consideraciones de una sentencia, tanto a las que son ratio decidendi como obiter dicta, que aportan fundamentos teóricos y empíricos que van a la par de la solución del problema jurídico planteado. Por ende, el objetivo de este artículo es proponer una reconstrucción del método de análisis jurisprudencial, junto con la esquematización de las maneras de realizar ese análisis, para finalmente proporcionar diversas herramientas que contribuyan a su desarrollo. Para así lograr el acercamiento de académicos, estudiantes, profesores y profesionales del derecho a la construcción del análisis jurisprudencial.
Develando los sentidos de la motrieidad en Colombia
Authors: Benjumea Pérez Margarita María , Castro Carvajal Julia Adriana , García Franco Clara Inés , Trigo Aza Eugenia , Zapata López Margarita María 
Published: January 2023

Con la sospecha de que en el área de la educación física existen brechas significativas entre la realidad (educación formal) y los propósitos y misión que tiene la disciplina en el desarrollo humano, un grupo de investigadores en red nacional con intervención internacional, trazó un proyecto de estudio con el objetivo de develar "Los sentidos de la motricidad a partir de la visión de los actores de la Educación Física en Colombia", como punto de partida para invitar a un cambio y ruptura de paradigmas en estecampo. En el estudio, se entiende por "Sentidos" el conjunto de percepciones, discursos, vivencias y prácticas docentes que los maestros de la educación física en Colombia tienen en relación con la Motricidad; dimensión que supera desde su complejidad la comprensión y significados de lo humano, el concepto biofisiológico del cuerpo y dualismo mecánico instrumental que se le asigna al movimiento en el trasegar histórico de la disciplina.
Entrenamiento, preparaciones físicas y lesiones en el fútbol
Authors: Gusi Fuertes Narcís 
Published: January 2023

El propósito es aportar medidas preventivas para el ejercicio profesional del entrenador y el preparador físico en fútbol. El análisis de las relaciones entre el proceso de entrenamiento deportivo, la condición física y las relaciones entre el proceso de entrenamiento deportivo, la condición física y las lesiones en el fútbol concluyen en cuatro aspectos: a) atender las cuatro fases de entrenamiento de cada sistema funcional y los eslabones perspectivos, reguladores y efectivos; b) una preparación física que buscara un equilibrio razonable entre los componentes de cada sistema funcional en diferentes situaciones (grado de fatiga, velocidad de ejecución, asimetrías, etc.); c) el desarrollo de la reserva de flexibilidad se combinar con el incremento de la fuerza y la elasticidad en todo el rango de movimiento de cada articulación; y d) se proponen una series de actividades deportivas durante el periodo de recuperación complementarias a las medidas medicas.
Perampanel in adjunctive therapy of patients with brain tumor-related epilepsy: real-world data
Authors: Samsonova G. G. , Zhidkova I. A. 
Published: January 2023

Background. Brain tumor-related epilepsy (BTRE) is an important and insufficiently studied interdisciplinary problem. In a significant part of brain tumor patients, the disease onsets with epileptic seizures. The course of tumor-associated epilepsy is often pharmacoresistant and requires rational polytherapy. To date, there are no uniform recommendations on the choice of an antiepileptic drug (AED) for the initial therapy of BTRE.Objective: retrospective analysis of the efficacy/tolerability of adjunctive therapy with perampanel in relation to epileptic seizures in patients with epilepsy associated with glial brain tumors and metastases.Material and methods. The analysis included 51 patients with glial tumors and brain metastases who were prescribed perampanel as part of adjunctive therapy. Its effectiveness against focal seizures (FS) and bilateral tonic-clonic seizures (BTCS) was evaluated at follow-up periods of >1≥3≥6 months. A decrease in the frequency of seizures by 50% or more (responders) or by 100% (seizure freedom) was analyzed. An analysis of the influence of intervening factors in a multifactorial model, an assessment of the effectiveness of perampanel as a whole and a stratified assessment of intervening factors were carried out. The frequency and profile of adverse events (AEs) were also evaluated, including their possible association with the use of other AED.Results. In the multifactorial model, independent predictors of the clinical effect were the onset of the disease in the form of FS at >1≥3≥6 months follow-up. None of AEDs used in the first line of therapy demonstrated an impact on the clinical effect. There were no predictors of clinical effect in patients with BTCS during the entire follow-up period. Out of 51 patients, 48 (94.1%) were responders, and in 36 of them (70.6%) the seizure freedom was registered. Among patients with FS, the proportion of responders was 83.3–90.9% at different follow-up periods, including 31.2–50.0% who showed seizure freedom. Among patients with BTCS, 86.7–92.3% became responders, including 56.1–88.5% who achieved seizure freedom. AEs were noted in 7 (13.7%) patients, the most common was aggression – 4 patients (7.8%). There were no cases required reduction the dose or discontinuation the treatment with perampanel due to AEs. In most patients at >1≥3≥6 months follow-up, the median was 6 mg/day.Conclusion. The study performed in real-world practice confirmed the high efficiency and safety of perampanel in the adjunctive therapy of epileptic seizures associated with glial brain tumors and metastases, which together with the low potential of drug interactions allow us recommend the drug to this contingent of patients.