bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Whether an Inpatient Initiative to Time Lab Draws in the Evening Reduces Anemia
Authors: Zaretsky Jonah , Eaton Kevin P , Sonne Christopher , Zhao Yunan , Jones Simon , Hochman Katherine , Blecker Saul 
Published: May 2023

Abstract

Background
Hospital acquired anemia is common during admission and can result in increased transfusion and length of stay. Recumbent posture is known to lead to lower hemoglobin measurements. We tested to see if an initiative promoting evening lab draws would lead to higher hemoglobin measurements due to more time in upright posture during the day and evening.

Methods
We included patients hospitalized on 2 medical units, beginning March 26, 2020 and discharged prior to January 25, 2021. On one of the units, we implemented an initiative to have routine laboratory draws in the evening rather than the morning starting on August 26, 2020. There were 1217 patients on the control unit and 1265 on the intervention unit during the entire study period. First we used a linear mixed-effects model to see if timing of blood draw was associated with hemoglobin level in the pre-intervention period. We then compared levels of hemoglobin before and after the intervention using a difference-in-difference analysis.

Results
In the pre-intervention period, evening blood draws were associated with higher hemoglobin compared to morning (0.28; 95% CI, 0.22–0.35). Evening blood draws increased with the intervention (10.3% vs 47.9%, P &gt; 0.001). However, the intervention floor was not associated with hemoglobin levels in difference-in-difference analysis (coefficient of −0.15; 95% CI, −0.51–0.21).

Conclusions
While evening blood draws were associated with higher hemoglobin levels, an intervention that successfully changed timing of routine labs to the evening did not lead to an increase in hemoglobin levels.
A method for characterization of stress concentration degree of coal mine roadway surrounding rock
Authors: Zhan Kai , Wen Xiaotao , Wang Xuben , Kong Chao 
Published: May 2023

Abstract
An accurate assessment of the stress concentration of the surrounding rock is crucial for ensuring safety in underground coal mines with a high potential for rockburst accidents. Traditional methods for measuring the stress of the surrounding rock use borehole stress-monitoring equipment and drilling and cutting methods. However, these methods do not always yield accurate and reliable data. In this study, we aim to explore the feasibility of a novel approach for characterizing stress concentration in surrounding rock using monitoring while drilling technology during large-diameter drilling. This study combined microseismic monitoring to collect vibration signals during the drilling process and collection of pulverized coal samples at each drilling stage. We analyzed the amplitude, number of coal vibration events and proportion of coarse pulverized coal. By integrating these indices, we characterized the stress concentration in the surrounding rock. Our approach was validated by comparing accurate, stable and representative data from deep- and shallow-hole stress gauges installed in similar locations and data from the conventional drilling cutting method. Our findings indicate that the proposed method provides a reliable and effective alternative to traditional techniques during large-diameter drilling. The proposed approach can significantly enhance safety management in underground coal mines prone to rockburst accidents.
A Primer on the Data Cleaning Pipeline
Authors: Steorts Rebecca C 
Published: May 2023

Abstract
The availability of both structured and unstructured databases, such as electronic health data, social media data, patent data, and surveys that are often updated in real time, among others, has grown rapidly over the past decade. With this expansion, the statistical and methodological questions around data integration, or rather merging multiple data sources, have also grown. Specifically, the science of the “data cleaning pipeline” contains four stages that allow an analyst to perform downstream tasks, predictive analyses, or statistical analyses on “cleaned data.” This article provides a review of this emerging field, introducing technical terminology and commonly used methods.
Observations of the planetary nebula SMP LMC 058 with the JWST MIRI medium resolution spectrometer
Authors: Jones O C , Álvarez-Márquez J , Sloan G C , Kavanagh P J , Argyriou I , Law D R , Labiano A , Patapis P , Mueller Michael , Larson Kirsten L , Bright Stacey N , Klaassen P D , Fox O D , Gasman Danny , Geers V C , Glauser Adrian M , Guillard Pierre , Nayak Omnarayani , Noriega-Crespo A , Ressler Michael E , Sargent B , Temim T , Vandenbussche B , Marín Macarena García 
Published: May 2023

Abstract
During the commissioning of JWST, the Medium-Resolution Spectrometer (MRS) on the Mid-Infrared Instrument (MIRI) observed the planetary nebula SMP LMC 058 in the Large Magellanic Cloud. The MRS was designed to provide medium resolution (R = λ/Δλ) 3D spectroscopy in the whole MIRI range. SMP LMC 058 is the only source observed in JWST commissioning that is both spatially and spectrally unresolved by the MRS and is a good test of JWST’s capabilities. The new MRS spectra reveal a wealth of emission lines not previously detected in this planetary nebula. From these lines, the spectral resolving power (λ/Δλ) of the MRS is confirmed to be in the range R = 4000 to 1500, depending on the MRS spectral sub-band. In addition, the spectra confirm that the carbon-rich dust emission is from SiC grains and that there is little to no time evolution of the SiC dust and emission line strengths over a 17-year epoch. These commissioning data reveal the great potential of the MIRI MRS for the study of circumstellar and interstellar material.
Restriction-modification systems have shaped the evolution and distribution of plasmids across bacteria
Authors: Shaw Liam P , Rocha Eduardo P C , MacLean R Craig 
Published: May 2023

Abstract
Many novel traits such as antibiotic resistance are spread by plasmids between species. Yet plasmids have different host ranges. Restriction-modification systems (R-M systems) are by far the most abundant bacterial defense system and therefore represent one of the key barriers to plasmid spread. However, their effect on plasmid evolution and host range has been neglected. Here we analyse the avoidance of targets of the most abundant R-M systems (Type II) for complete genomes and plasmids across bacterial diversity. For the most common target length (6 bp) we show that target avoidance is strongly correlated with the taxonomic distribution of R-M systems and is greater in plasmid genes than core genes. We find stronger avoidance of R-M targets in plasmids which are smaller and have a broader host range. Our results suggest two different evolutionary strategies for plasmids: small plasmids primarily adapt to R-M systems by tuning their sequence composition, and large plasmids primarily adapt through the carriage of additional genes protecting from restriction. Our work provides systematic evidence that R-M systems are important barriers to plasmid transfer and have left their mark on plasmids over long evolutionary time.
ncOrtho: efficient and reliable identification of miRNA orthologs
Authors: Langschied Felix , Leisegang Matthias S , Brandes Ralf P , Ebersberger Ingo 
Published: May 2023

Abstract
MicroRNAs (miRNAs) are post-transcriptional regulators that finetune gene expression via translational repression or degradation of their target mRNAs. Despite their functional relevance, frameworks for the scalable and accurate detection of miRNA orthologs are missing. Consequently, there is still no comprehensive picture of how miRNAs and their associated regulatory networks have evolved. Here we present ncOrtho, a synteny informed pipeline for the targeted search of miRNA orthologs in unannotated genome sequences. ncOrtho matches miRNA annotations from multi-tissue transcriptomes in precision, while scaling to the analysis of hundreds of custom-selected species. The presence-absence pattern of orthologs to 266 human miRNA families across 402 vertebrate species reveals four bursts of miRNA acquisition, of which the most recent event occurred in the last common ancestor of higher primates. miRNA families are rarely modified or lost, but notable exceptions for both events exist. miRNA co-ortholog numbers faithfully indicate lineage-specific whole genome duplications, and miRNAs are powerful markers for phylogenomic analyses. Their exceptionally low genetic diversity makes them suitable to resolve clades where the phylogenetic signal is blurred by incomplete lineage sorting of ancestral alleles. In summary, ncOrtho allows to routinely consider miRNAs in evolutionary analyses that were thus far reserved to protein-coding genes.
Multi-omics for COVID-19: driving development of therapeutics and vaccines
Authors: Guo Mengyu , Xiong Muya , Peng Jinying , Guan Tong , Su Haixia , Huang Yanyi , Yang Cai-Guang , Li Yang , Boraschi Diana , Pillaiyar Thanigaimalai , Wang Guanbo , Yi Chengqi , Xu Yechun , Chen Chunying 
Published: May 2023

ABSTRACT
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for public health and economy. The development of therapeutics and vaccines to combat this virus is continuously progressing. Multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, epigenomics and metallomics, have helped understand the structural and molecular features of the virus, thereby assisting in the design of potential therapeutics and accelerating vaccine development for COVID-19. Here, we provide an up-to-date overview of the latest applications of multi-omics technologies in strategies addressing COVID-19, in order to provide suggestions towards the development of highly effective knowledge-based therapeutics and vaccines.
Entertainments from a Medieval Minstrel’s Repertoire Book
Authors: Wade James 
Published: May 2023

Abstract
National Library of Scotland, Advocates’ MS 19.3.1 (the Heege Manuscript) is a large, late-fifteenth-century English miscellany manuscript from the border of Derbyshire and Nottinghamshire. Its first booklet, which existed independently of the manuscript’s other eight booklets throughout much or all of its medieval life, contains three texts: the tail-rhyme burlesque romance The Hunting of the Hare, a mock sermon in prose, and the alliterative nonsense verse The Battle of Brackonwet. This essay proposes that Richard Heege, the booklet’s scribe, copied these texts from the repertoire of a local entertainer, be that a gifted amateur or, very plausibly, a travelling minstrel working a regular beat. In this light, the booklet’s comic, crude, and sometimes frivolous contents take on new significance in the history of English literature, as they provide close evidence for what made up the entertainments of English oral culture—or minstrelsy—at the end of the Middle Ages.
Mapping the fraction of dwellings exceeding radon level thresholds in the Lazio region, central Italy
Authors: Salvi Francesco 
Published: May 2023

Abstract
The risks arising from exposure to radon in buildings call for the planning of actions to reduce indoor radon levels. Maps of the fraction of dwellings above a threshold make it possible to identify areas where actions can be concentrated to optimize resources. The grid square method was applied to data collected in the radon survey carried out in the Lazio region, located in central Italy, to estimate the fractions of dwellings with radon concentrations above 100, 200 and 300 Bq m−3. Spatial correlation between radon measurements was used to improve the estimates. Depending on the threshold, selecting areas where &gt;10% of dwellings are above, the territory covered varies from about 100% to about 20% of the entire region.
Comparison of sleep parameters from wrist-worn ActiGraph and Actiwatch devices
Authors: Liu Fangyu , Schrack Jennifer , Wanigatunga Sarah K , Rabinowitz Jill A , He Linchen , Wanigatunga Amal A , Zipunnikov Vadim , Simonsick Eleanor M , Ferrucci Luigi , Spira Adam P 
Published: May 2023

Abstract
Sleep and physical activity, two important health behaviors, are often studied independently using different accelerometer types and body locations. Understanding whether accelerometers designed for monitoring each behavior can provide similar sleep parameter estimates may help determine whether one device can be used to measure both behaviors. Three hundred and thirty one adults (70.7 ± 13.7 years) from the Baltimore Longitudinal Study of Aging wore the ActiGraph GT9X Link and the Actiwatch 2 simultaneously on the non-dominant wrist for 7.0 ± 1.6 nights. Total sleep time (TST), wake after sleep onset (WASO), sleep efficiency, number of wake bouts, mean wake bout length, and sleep fragmentation index (SFI) were extracted from ActiGraph using the Cole–Kripke algorithm and from Actiwatch using the software default algorithm. These parameters were compared using paired t-tests, Bland–Altman plots, and Deming regression models. Stratified analyses were performed by age, sex, and body mass index (BMI). Compared to the Actiwatch, the ActiGraph estimated comparable TST and sleep efficiency, but fewer wake bouts, longer WASO, longer wake bout length, and higher SFI (all p &lt; .001). Both devices estimated similar 1-min and 1% differences between participants for TST and SFI (β = 0.99, 95% CI: 0.95, 1.03, and 0.91, 1.13, respectively), but not for other parameters. These differences varied by age, sex, and/or BMI. The ActiGraph and the Actiwatch provide comparable absolute and relative estimates of TST, but not other parameters. The discrepancies could result from device differences in movement collection and/or sleep scoring algorithms. Further comparison and calibration is required before these devices can be used interchangeably.
Restricted- and over-feeding during gestation decreases growth of offspring throughout maturity
Authors: Tillquist Nicole M , Reed Sarah A , Kawaida Mia Y , Reiter Amanda S , Smith Brandon I , Jang Hyung , Lee Ji-Young , Lee Elaine C , Zinn Steven A , Govoni Kristen E 
Published: May 2023

Abstract
To determine the effects of poor maternal nutrition on the growth and metabolism of offspring into maturity, multiparous Dorset ewes pregnant with twins (n = 46) were fed to either 100% (control; n = 13), 60% (restricted; n = 17), or 140% (over; n = 16) of National Research Council requirements from day 30 ± 0.02 of gestation until parturition. Offspring of these ewes are referred to as CON (n = 10 ewes; 12 rams), RES (n = 13 ewes; 21 rams), or OVER (n = 16 ewes; 13 rams), respectively. Lamb body weights (BW) and blood samples were collected weekly from birth (day 0) to day 28 and then every 14 d until day 252. Intravenous glucose tolerance test (infusion of 0.25 g dextrose/kg BW) was performed at day 133 ± 0.25. At day 167 ± 1.42, individual daily intake was recorded over a 77 d feeding period to determine residual feed intake (RFI). Rams were euthanized at day 282 ± 1.82 and body morphometrics, loin eye area (LEA), back fat thickness, and organ weights were collected. The right leg was collected from rams at necropsy and dual-energy x-ray absorptiometry was used to determine bone mineral density (BMD) and length. Averaged from day 0 until day 252, RES and OVER offspring weighed 10.8% and 6.8% less than CON offspring, respectively (P ≤ 0.02). When adjusted for BW, liver and testes weights tended to be increased and decreased, respectively, in RES rams compared with CON rams (P ≤ 0.08). Additionally, RES BMD and bone length were less than CON rams (P ≤ 0.06). Treatment did not influence muscle mass, LEA, or adipose deposition (P ≥ 0.41). Rams (−0.17) were more feed efficient than ewes (0.23; P &lt; 0.01); however, no effect of maternal diet was observed (P ≥ 0.57). At 2 min post glucose infusion, glucose concentrations in OVER offspring were greater than CON and RES offspring (P = 0.04). Concentrations of insulin in CON rams tended to be greater than OVER and RES ewes at 5 min (P ≤ 0.07). No differences were detected in insulin:glucose or area under the curve (AUC) for glucose or insulin (P ≤ 0.29). Maternal diet did not impact offspring triglycerides or cholesterol (P ≤ 0.35). Pre-weaning leptin tended to be 70% greater in OVER offspring than CON (P ≤ 0.07). These data indicate that poor maternal nutrition impairs offspring growth throughout maturity but does not affect RFI. Changes in metabolic factors and glucose tolerance are minimal, highlighting the need to investigate other mechanisms that may contribute to negative impacts of poor maternal diet.
Tectorigenin relieved sepsis-induced myocardial ferroptosis by inhibiting the expression of Smad3
Authors: Fang Xiaowei , Fu Wei , Zou Bing , Zhang Fei 
Published: May 2023

Abstract

Background
Myocardial injury is a serious consequence of sepsis that contributes to high rates of death. Currently, the pathophysiology of cardiac damage in sepsis is still unknown, and treatment approaches are limited.

Methods
The sepsis mouse model was established inducing by Lipopolysaccharide (LPS) in vivo and Tectorigenin was pretreated to explore whether it contributed to alleviated myocardial injury. Hematoxylin-eosin (HE) stain was employed to evaluate the myocardial injury severity. TUNEL assay measured the number of apoptosis cells and the levels of B-cell lymphoma-2 associated X (Bax) and Cleaved Caspase-3 were assessed by western blot. The contents of iron and related ferroptosis molecules (acyl-CoA synthetase long-chain family (ACSL4), Glutathione Peroxidase 4 (GPX4)) were assessed. Then, interleukin-1β (IL-1β), IL-18, IL-6, tumor necrosis factor-α (TNF-α), and other inflammatory-related cytokines were detected by ELISA. The expression of the mother against decapentaplegic homolog 3 (Smad3) in heart tissues was evaluated by western blot and immunofluorescence.

Results
Tectorigenin alleviated myocardial dysfunction and myofibrillar disruption in LPS-related sepsis groups. Tectorigenin ameliorated cardiomyocyte apoptosis and myocardial ferroptosis in LPS-stimulated sepsis mice. Tectorigenin reduced inflammatory-relevant cytokines in the cardiac tissues of LPS stimuli mice. In addition, we further confirm that Tectorigenin relieved myocardial ferroptosis by inhibiting the expression of Smad3.

Discussion
Tectorigenin ameliorates myocardial damage stimulated by LPS and this effect exerts by inhibiting ferroptosis and the inflammation of the myocardium. Furthermore, the inhibitory effect of Tectorigenin on ferroptosis may deregulate Smad3 expression. Taken together, Tectorigenin may be a viable method for alleviating myocardial damage in sepsis.
Harnessing the Potential of Older Workers Through Relationships at Work: Social Support, Feedback, and Performance
Authors: Marques Tatiana , Ramos Sara , Patient David , Bobocel D Ramona 
Published: May 2023

Abstract
With the aging of the global workforce, it is crucial to deepen our understanding of how to keep older workers healthy, motivated, and productive. In this research, we integrate job design with socioemotional selectivity theory to propose that social job characteristics relate to employee performance differently for older and younger workers. Specifically, in a 3-wave survey (N = 454), we tested employee age as a moderator of the relationships between receiving social support and feedback at work, and performance, as well as giving social support and feedback at work, and performance. The results showed that, in general, both receiving and giving social support and feedback are associated more strongly with the performance of older than younger workers. The findings provide important theoretical implications for the study of aging and work; they also offer practical applications for creating workplaces in which older workers can reap the benefits of social relationships to remain productive.
Strategies to Support Faculty Caregivers at U.S. Medical Schools
Authors: Cutter Christina M. , Szczygiel Lauren A. , Jones Rochelle DeCastro , Perry Lydia , Mangurian Christina , Jagsi Reshma 
Published: May 2023

Purpose
To describe the policies, processes, and programs at U.S. medical schools to support faculty caregivers before and in response to the COVID-19 pandemic.

Method
In 2021, the Doris Duke Charitable Foundation and founding members of the COVID-19 Fund to Retain Clinical Scientists (FRCS) Collaborative launched and supported the COVID-19 FRCS program to recognize medical schools and their efforts to strengthen policies, processes, and programs supporting biomedical faculty with family caregiving responsibilities in the context of COVID-19-related impacts. The authors conducted a qualitative conceptual content analysis of the deidentified, open-ended responses submitted by institutions in their applications to the COVID-19 FRCS program and summarized the reported strategies using recurring patterns and common approaches.

Results
Fifty-four institutions applied to the COVID-19 FRCS program in 2021 and were included in this study. COVID-19-related impacts on biomedical faculty included stymied career progression and academic productivity, exacerbated career-caregiving time conflicts, adverse effects on family and personal well-being and mental health, increased financial hardships, and amplified faculty caregiver stigma. The described policies, processes, and programs to support faculty caregivers fell into 4 domains: support for dependent care, career and workplace flexibility, career development support, and institutional culture change to reduce stigma. COVID-19-related modifications spanned these domains with remote and flexible work manifesting as disruptive changes. Strategies to support women and underrepresented in medicine faculty, who bear a disproportionate burden of caregiving responsibilities, centered on career development support and institutional culture change. The projected durability of the enacted changes varied by institution and across strategies.

Conclusions
The COVID-19 pandemic presents a disruptive opportunity to translate lessons learned into positive change to better support faculty caregivers, particularly women and underrepresented in medicine faculty. This study’s findings provide a framework to guide sustainable change to support equity, diversity, and vitality in the academic biomedical workforce.