bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interfacial Proton Supply/Filtration Regulates the Dynamics of Electrocatalytic Nitrogen Reduction Reaction: A Perspective
Authors: Cheng Yu , Xu Xinnan , Wang Mengfan , Deng Chengwei , Sun Yi , Yan Chenglin , Qian Tao 
Published: July 2023

AbstractAs a promising energy carrier, ammonia synthesis by electrocatalytic nitrogen reduction reaction (eNRR) is a promising green and low‐carbon ammonia synthesis strategy that can replace the traditional Haber–Bosch process. However, the development of eNRR processes is mainly severely constrained by competitive hydrogen evolution reaction (HER), and the corresponding strategies to inhibit this adverse side reaction to obtain high eNRR selectivity are still limited. In addition, for this complex reaction involving gas–liquid–solid three‐phase interface and proton/electron transfer, it is great significance to analyze and summarize the existing inhibition HER strategies from the viewpoint of dynamics. In view of this, this work reviews proton supply/filtration regulation strategy in catalytic system, allowing a systematic survey of the literature focusing on interface membrane regulation (inorganic membrane and organic membrane), electrolyte regulation (metal‐mediated strategy and electrolyte ion regulation strategy) and system device design (electrode structure design and electrolytic cell device design). Constructive catalytic system design guidance is also suggested to inhibit hydrogen evolution and improve NH3 selectivity, aiming for scalable and economically feasible applications.
Evidence for Glass–glass Interfaces in a Columnar Cu–Zr Nanoglass
Authors: Voigt Hendrik , Rigoni Aaron , Boltynjuk Evgeniy , Chellali Mohammed Reda , Tyler Bonnie , Rösner Harald , Divinski Sergiy , Hahn Horst , Wilde Gerhard 
Published: July 2023

AbstractComprehensive analyses of the atomic structure using advanced analytical transmission electron microscopy‐based methods combined with atom probe tomography confirm the presence of distinct glass–glass interfaces in a columnar Cu‐Zr nanoglass synthesized by magnetron sputtering. These analyses provide first‐time in‐depth characterization of sputtered film nanoglasses and indicate that glass–glass interfaces indeed present an amorphous phase with reduced mass density as compared to the neighboring amorphous regions. Moreover, dedicated analyses of the diffusion kinetics by time‐of‐flight secondary ion mass spectroscopy (ToF SIMS) prove significantly enhanced diffusivity, suggesting fast transport along the low density glass–glass interfaces. The present results further indicate that sputter deposition is a feasible technique for reliable production of nanoglasses and that some of the concepts proposed for this new class of glassy materials are applicable.
Internal Light Sources‐Mediated Photodynamic Therapy Nanoplatforms: Hope for the Resolution of the Traditional Penetration Problem
Authors: An Yibo , Xu Dazhuang , Wen Xiaofei , Chen Chuan , Liu Gang , Lu Zhixiang 
Published: July 2023

AbstractPhotodynamic therapy (PDT) is an alternative cancer treatment technique with a noninvasive nature, high selectivity, and minimal adverse effects. The indispensable light source used in PDT is a critical factor in determining the energy conversion of photosensitizers (PSs). Traditional light sources are primarily concentrated in the visible light region, severely limiting their penetration depth and making them prone to scattering and absorption when applied to biological tissues. For that reason, its efficacy in treating deep‐seated lesions is often inadequate. Self‐exciting PDT, also known as auto‐PDT (APDT), is an attractive option for circumventing the limited penetration depth of traditional PDT and has acquired significant attention. APDT employs depth‐independent internal light sources to excite PSs through resonance or radiative energy transfer. APDT has considerable potential for treating deep‐tissue malignancies. To facilitate many researchers' comprehension of the latest research progress in this field and inspire the emergence of more novel research results. This review introduces internal light generation mechanisms and characteristics and provides an overview of current research progress based on the recently reported APDT nanoplatforms. The current challenges and possible solutions of APDT nanoplatforms are also presented and provide insights for future research in the final section of this article.
A Nanoconfined Water–Ion Coordination Network for Flexible Energy‐Dissipation Devices
Authors: Gao Yuan , Li Mingzhe , Zhan Chi , Zhang Haozhe , Yin Mengtian , Lu Weiyi , Xu Baoxing 
Published: July 2023

AbstractWater–ion interaction in a nanoconfined environment that deeply constrains spatial freedoms of local atomistic motion with unconventional coupling mechanisms beyond that in a free, bulk state is essential to spark designs of a broad spectrum of nanofluidic devices with unique properties and functionalities. Here, it is reported that the interaction between ions and water molecules in a hydrophobic nanopore forms a coordination network with an interaction density that is nearly fourfold that of the bulk counterpart. Such strong interaction facilitates the connectivity of the water–ion network and is uncovered by corroborating the formation of ion clusters and the reduction of particle dynamics. A liquid‐nanopore energy‐dissipation system is designed and demonstrated in both molecular simulations and experiments that the formed coordination network controls the outflow of confined electrolytes along with a pressure reduction, capable of providing flexible protection for personnel and devices and instrumentations against external mechanical impact and attack.
High‐Sensitivity RFID Sensor for Structural Health Monitoring
Authors: Nesser Hussein , Mahmoud Hassan A. , Lubineau Gilles 
Published: July 2023

AbstractStructural health monitoring (SHM) is crucial for ensuring operational safety in applications like pipelines, tanks, aircraft, ships, and vehicles. Traditional embedded sensors have limitations due to expense and potential structural damage. A novel technology using radio frequency identification devices (RFID) offers wireless transmission of highly sensitive strain measurement data. The system features a thin, flexible sensor based on an inductance‐capacitance (LC) circuit with a parallel‐plate capacitance sensing unit. By incorporating tailored cracks in the capacitor electrodes, the sensor’s capacitor electrodes become highly piezoresistive, modifying electromagnetic wave penetration. This unconventional change in capacitance shifts the resonance frequency, resulting in a wireless strain sensor with a gauge factor of 50 for strains under 1%. The frequency shift is passively detected through an external readout system using simple frequency sweeping. This wire‐free, power‐free design allows easy integration into composites without compromising structural integrity. Experimental results demonstrate the cracked wireless strain sensor's ability to detect small strains within composites. This technology offers a cost‐effective, non‐destructive solution for accurate structural health monitoring.
Recent Advances in Polymerization‐Induced Self‐Assembly (PISA) Syntheses in Non‐Polar Media
Authors: György Csilla , Armes Steven P. 
Published: July 2023

AbstractIt is well‐known that polymerization‐induced self‐assembly (PISA) is a powerful and highly versatile technique for the rational synthesis of colloidal dispersions of diblock copolymer nanoparticles, including spheres, worms or vesicles. PISA can be conducted in water, polar solvents or non‐polar media. In principle, the latter formulations offer a wide range of potential commercial applications. However, there has been just one review focused on PISA syntheses in non‐polar media and this prior article was published in 2016. The purpose of the current review article is to summarize the various advances that have been reported since then. In particular, PISA syntheses conducted using reversible addition‐fragmentation chain‐transfer (RAFT) polymerization in various n‐alkanes, poly(α‐olefins), mineral oil, low‐viscosity silicone oils or supercritical CO2 are discussed in detail. Selected formulations exhibit thermally induced worm‐to‐sphere or vesicle‐to‐worm morphological transitions and the rheological properties of various examples of worm gels in non‐polar media are summarized. Finally, visible absorption spectroscopy and small‐angle X‐ray scattering (SAXS) enable in situ monitoring of nanoparticle formation, while small‐angle neutron scattering (SANS) can be used to examine micelle fusion/fission and chain exchange mechanisms.
Construction of an Oxidative Cleavage‐Activated DNAzyme Biosensor for Rapid Detection and Cellular Imaging of the Myeloperoxidase Activity
Authors: Liu Ming‐Hao , Zhao Ning‐Ning , Yu Wan‐Tong , Zhang Jin‐Zhi , Wang Zi‐Yue , Zhang Chun‐Yang 
Published: July 2023

AbstractMyeloperoxidase (MPO) is a mammalian pro‐oxidant protease and it is closely related to severe infections and diverse inflammatory diseases. Rapid and sensitive measurement of MPO activity is essential for anticancer drug discovery and inflammatory research. Herein, we demonstrate the construction of an oxidative cleavage‐activated deoxyribozymes (DNAzyme) biosensor for rapid detection and cellular imaging of the MPO activity. When target MPO is present, the phosphorothioate (PS)‐modified hairpin probe is site‐specifically cleaved by MPO, releasing the intact Mg2+‐dependent DNAzyme sequences. Subsequently, the activated DNAzyme initiates the cyclic cleavage of the signal probe with the assistance of cofactor Mg2+, liberating large numbers of Cy5 molecules. This assay possesses the characteristics of easy operation, low sample consumption, without the requirements of expensive radiolabeling, antibodies, and nanomaterials. Especially, this assay can be performed in one pot under isothermal conditions (37°C) within 60 min. Due to the high efficiency of DNAzyme‐based cyclic cleavage reaction and the intrinsic advantages of single‐molecule detection, this assay achieves high sensitivity with a limit of detection (LOD) of 2.74×10−3 ng μL−1. It can be applied to screen MPO inhibitors, measure cellular MPO activity at the single‐cell level, and image intracellular MPO in living cells, providing a powerful platform for early clinical diagnosis and drug discovery.
Novel admissibility and robust stabilization conditions for fractional‐order singular systems with polytopic uncertainties
Authors: Zhang Qing‐Hao , Lu Jun‐Guo 
Published: July 2023

AbstractThis paper considers the issues of the admissibility and robust stabilization of fractional‐order singular systems with polytopic uncertainties and fractional‐order
and
. Firstly, the novel admissibility conditions for nominal fractional‐order singular systems are proposed with no conservatism and without any equalities or nonstrict inequalities. Secondly, the robust admissibility conditions for fractional‐order singular systems with polytopic uncertainties are given based on the admissibility conditions for nominal fractional‐order singular systems. Thirdly, to make the uncertain fractional‐order singular systems robustly admissible, the methods of designing the static output feedback controllers are obtained with wider application scope, which are direct, concise, and more relaxed compared with the existing results. All the results are proposed in terms of linear matrix inequalities. Finally, three illustrative examples are given to demonstrate the effectiveness of the results.
No differences in implicit hand maps among different degrees of autistic traits
Authors: Hidaka Souta , Chen Na , Ishii Naomi , Iketani Risa , Suzuki Kirino , Longo Matthew R. , Wada Makoto 
Published: July 2023

AbstractPeople with autism spectrum disorder (ASD) or higher levels of autistic traits have atypical characteristics in sensory processing. Atypicalities have been reported for proprioceptive judgments, which are tightly related to internal bodily representations underlying position sense. However, no research has directly investigated whether self‐bodily representations are different in individuals with ASD. Implicit hand maps, estimated based on participants' proprioceptive sensations without sight of their hand, are known to be distorted such that the shape is stretched along the medio‐lateral hand axis even for neurotypical participants. Here, with the view of ASD as falling on a continuous distribution among the general population, we explored differences in implicit body representations along with autistic traits by focusing on relationships between autistic traits and the magnitudes of the distortions in implicit hand maps (N ~ 100). We estimated the magnitudes of distortions in implicit hand maps both for fingers and hand surfaces on the dorsal and palmar sides of the hand. Autistic traits were measured by questionnaires (Autism Spectrum [AQ] and Empathy/Systemizing [EQ‐SQ] Quotients). The distortions in implicit hand maps were replicated in our experimental situations. However, there were no significant relationships between autistic traits and the magnitudes of the distortions as well as within‐individual variabilities in the maps and localization performances. Consistent results were observed from comparisons between IQ‐matched samples of people with and without a diagnosis of ASD. Our findings suggest that there exist perceptual and neural processes for implicit body representations underlying position sense consistent across levels of autistic traits.
A dual‐function fluorescent probe for the detection of pH values and formaldehyde
Authors: Deng Bing , Ding Leyuan , Yang Shaoxiang , Tian Hongyu , Sun Baoguo 
Published: July 2023

AbstractA dual‐function fluorescent probe (Probe 1) was developed in this work for the separate detection of pH value and formaldehyde (HCHO). Probe 1 could recognize HCHO and the pH value from the amino group. The colour of the probe solution was changed from grey blue to light blue with the increase in the pH value, and luminous intensity became larger with the increase in formaldehyde concentration. The curve function relationship between fluorescence intensity and the pH value was also determined. A smartphone containing a colour detector for imaging was used to record the values of the three primary colours (R value, G value, and B value) for the probe solution in formaldehyde. Importantly, there was a linear functional relationship between the B*R/G value with HCHO concentration. Therefore, the probe could be used as a rapid tool for the detection of formaldehyde. More importantly, Probe 1 was successfully used to detect formaldehyde in an actual distilled liquor sample.
Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi‐institutional study
Authors: Liu Xin , Yue Han , Jiang Shiyu , Kong Lin , Xu Yu , Chen Yong , Wang Chunmeng , Wang Yan , Zhu Xiaoli , Kong Yunyi , Zhang Xiaowei , Qian Jiang , Luo Zhiguo 
Published: July 2023

AbstractPurposeMetastatic ocular and orbital melanomas are extremely rare. The clinical characteristics and standard treatments for these patients are not fully established.Materials and MethodsWe retrospectively analyzed patients with metastatic ocular and orbital melanoma from Fudan University Shanghai Cancer Center and Eye & ENT Hospital of Fudan University between January 2012 and May 2022.ResultsOverall, 51 patients with metastatic ocular and orbital melanoma were included. The most common primary sites were uvea (73%), followed by conjunctiva (22%), lacrimal sac (4%), and orbit (2%). Patients with uveal melanoma (UM) had a significantly younger age (48 vs. 68 years, p < 0.001), higher incidence of liver metastases (89% vs. 9%, p<0.001), a lower incidence of lymph nodes metastases (16% vs. 46%, p = 0.043) and a lower incidence of BRAF mutation (0% vs. 55%, p<0.001) compared with patients with conjunctival melanoma (CM). The overall response rate of the first‐line treatment was 18%. Three of the four patients with BRAF‐mutated CM responded to dabrafenib and trametinib treatment. The median progression‐free survival (PFS) and overall survival (OS) of first‐line treatment were 5.1 and 11.9 months, respectively. Among patients with liver metastases, liver‐directed treatment was correlated with better patient PFS (p < 0.001) and OS (p < 0.001) after adjusting for number of metastatic sites and primary sites.ConclusionCM and UM have different characteristics. Patient with CM had a high incidence of BRAF mutation, and the treatment of BRAF and MEK inhibitors conferred clinical benefit. Liver directed therapies had a potential benefit in disease control in patients with liver metastases.
Compliance to genomic test recommendations to guide adjuvant chemotherapy decision‐making in the case of hormone receptor‐positive, human epidermal growth factor receptor 2‐negative breast cancer, in real‐life settings
Authors: Hequet D. , Hajjaji N. , Charafe‐Jauffret E. , Boucrauta A. , Dalenc F. , Nicolai V. , Lopez J. , Tredan O. , Deluche E. , Fermeaux V. , Tixier L. , Cayre A. , Menet E. , Lerebours F. , Rouzier R. 
Published: July 2023

AbstractBackgroundGenomic tests are a useful tool for adjuvant chemotherapy decision‐making in the case of hormone receptor‐positive (HR+), and human epidermal growth factor receptor 2‐negative (HER2−) breast cancer with intermediate prognostic factors. Real‐life data on the use of tests can help identify the target population for testing.MethodsFrench multicentric study (8 centers) including patients, all candidates for adjuvant chemotherapy for HR‐positive, HER2‐negative early breast cancer. We describe the percentage of tests performed outside recommendations, according to the year of testing. We calculated a ratio defined as the number of tests required to avoid chemotherapy for one patient, and according to patient and cancer characteristics. We then performed a cost‐saving analysis using medical cost data over a period of 1 year from diagnosis, calculated from a previous study. Finally, we calculated the threshold of the ratio (number of tests required to avoid chemotherapy for one patient) below which the use of genomic tests was cost‐saving.ResultsA total of 2331 patients underwent a Prosigna test. The ratio (performed test/avoided chemotherapy) was 2.8 [95% CI: 2.7–2.9] in the whole population. In the group following recommendations for test indication, the ratio was 2.3 [95% CI: 2.2–2.4]. In the case of non‐abidance by recommendations, the ratio was 3 [95% CI: 2.8–3.2]. Chemotherapy was avoided in 841 patients (36%) following the results of the Prosigna test. The direct medical costs saved over 1 year of care were 3,878,798€ and 1,718,472€ in the group of patients following test recommendations. We calculated that the ratio (performed test/avoided chemotherapy) needed to be under 6.9 for testing to prove cost‐saving.ConclusionThe use of genomic testing proved cost‐saving in this large multicentric real‐life analysis, even in certain cases when the test was performed outside recommendations.
Casearia Essential Oil: An Updated Review on the Chemistry and Pharmacological Activities
Authors: Alexandre Carvalho Flavio , Valadares de Moraes Natália , Eduardo Miller Crotti Antônio , José Crevelin Eduardo , Gonzaga dos Santos André 
Published: July 2023

AbstractCasearia species are found in the America, Africa, Asia, and Australia and present pharmacological activities, besides their traditional uses. Here, we reviewed the chemical composition, content, pharmacological activities, and toxicity of the essential oils (EOs) from Casearia species. The EO physical parameters and leaf botanical characteristics were also described. The bioactivities of the EOs from the leaves and their components include cytotoxicity, anti‐inflammatory, antiulcer, antimicrobial, antidiabetic, antioxidant, antifungal, and antiviral activities. The main components associated with these activities are the α‐zingiberene, (E)‐caryophyllene, germacrene D, bicyclogermacrene, spathulenol, α‐humulene, β‐acoradiene, and δ‐cadinene. Data on the toxicity of these EOs are scarce in the literature. Casearia sylvestris Sw. is the most studied species, presenting more significant pharmacological potential. The chemical variability of EOs components was also investigated for this species. Caseria EOs have relevant pharmacological potential and must be further investigated and exploited.
Successfully drug treatment for necrotizing fasciitis caused by Streptococcus pyogenes in 88‐year‐old patient
Authors: Ladjouzi Nadia , Ben Hassen Jihène , Mebarki Idir , Al Zoabi Mohamad , Alaysh Adel , Schlatter Joël 
Published: July 2023

Key Clinical MessageNecrotizing fasciitis (NF) is a rare soft‐tissue infection generally treated by emergency surgical intervention. We report a case of successfully drug treatment for NF in older patient with comorbidities thus avoiding surgical intervention.
Critical Issues of Vanadium‐Based Cathodes Towards Practical Aqueous Zn‐Ion Batteries
Authors: Jiang Weikang , Zhu Kaiyue , Yang Weishen 
Published: July 2023

AbstractAqueous zinc‐ion batteries (ZIBs) are gaining significant attention for their numerous advantages, including high safety, high energy density, affordability, and environmental friendliness. However, the development of ZIBs has been hampered by the lack of suitable cathode materials that can store Zn2+ with high capacity and reversibility. Currently, vanadium‐based materials with tunnel or layered structures are widely researched owing to their high theoretical capacity and diversified structures. However, their long‐term cycling stability is unsatisfactory because of material dissolution, phase transformation, and restrictive kinetics in aqueous electrolytes, which limits their practical applications. Different from previous reviews on ZIBs, this review specifically addresses the critical issues faced by vanadium‐based cathodes for practical aqueous ZIBs and proposes potential solutions. Focusing on vanadium‐based cathodes, their ion storage mechanisms, the critical parameters affecting their performance, and the progress made in addressing the aforementioned problems are also summarized. Finally, future directions for the development of practical aqueous ZIB are suggested.
Monomer Recycling as Complementary Technology in a Circular Economy
Authors: Brepohl Esther , Paschetag Mandy , Scholl Stephan 
Published: July 2023

AbstractPlastic waste is one of the major challenges facing modern society. Against the background of climate change and finite fossil resources, the realization of a true circular economy for plastics is imperative. Mechanical recycling processes offer a short‐cut path for the recycling of clean, single material waste while they are not capable to handle mixed material or colored feeds. Complementary technologies are necessary to recover pure monomers, hydrocarbon mixtures or syngas from mixed secondary raw material to continuously close the loop in a circular plastics economy. Using the example of PET, this contribution discusses the benefit of integrating a back‐to‐monomer recycling for closing the loop aiming at a holistically approach integrating technological, ecological and economic aspects.