bluuebunny/crossref_metadata_2025_split huggingface dataset:
CROSSING KIRSCHNER WIRES DURING SURGIAL FIXATION FOR BASE OF FIFTH METACARPAL FRACTURES: A RISK FACTOR FOR POSTOPERATIVE INFECTION?
Authors: Biddle M. , Wilson V. , Phillips S. , Miller N. , Little K. , Martin D. 
Published: March 2023

Our aim was to explore factors associated with early post operative infection for surgically managed base of 4th/5th metacarpal fractures. We hypothesised that K-wires crossing the 4th and 5th carpometacarpal joint (CMCJ) would be associated with an increased risk of post-operative infection.Data from consecutive patients requiring surgical fixation for a base of 4th/5th metacarpal fracture from October 2016 to May 2021 were collected. Patient demographics, time to surgery, length of surgery, operator experience, use of tourniquet, intra-operative antibiotics, number and thickness of K-wire used, as well as whether or not the K-wires crossed CMCJ joints were recorded. Factors associated with post operative infection were assessed using Chi Squared test and univariable logistic regression using R studio.Of 107 patients, 10 (9.3%) suffered post operative infection. Time to surgery (p 0.006) and length of operation (p=0.005) were higher in those experiencing infection. There was a trend towards higher risk of infection seen in those who had K-wires crossed (p=0.06). On univariable analysis, patients who had wires crossed were >7 times more likely to experience infection than those who didn't (OR 7.79 (95% CI, 1.39 - 146.0, p=0.056). Age, smoking, K-wire size, number of K-wires used, intraoperative antibiotics, tourniquet use and operator experience were not associated with infection.In patients with a base of 4th/5th metacarpal fractures requiring surgical fixation, we find an increased risk of post-operative infection associated with K-wires crossing the CMCJ, which has implications for surgical technique. Larger prospective studies would be useful in further delineating these findings.
PROJECTED HIP FRACTURE INCIDENCE IN SCOTLAND
Authors: Harris E. , Farrow L. , Martin C. , Adam K. , Holt G. 
Published: March 2023

The hip fracture burden on health and social care services in Scotland is anticipated to increase significantly, primarily driven by an ageing population. This study forecasts future hip fracture incidence and the annual number of hip fractures in Scotland until 2029.The monthly number of patients with hip fracture aged ≥ 50 admitted to a Scottish hospital between 01/01/2017 and 31/12/2021 was identified through data collected by the Scottish Hip Fracture Audit. This data was analysed using Exponential Smoothing and Auto Regressive Integrated Moving Average forecast modelling to project future hip fracture incidence and the annual number of hip fractures until 2029. Adjustments for population change were accounted for by integrating population projections published by National Records of Scotland.Between 2017 and 2021 the annual number of hip fractures in Scotland increased from 6675 to 7797, with a respective increase in hip fracture incidence from 313 to 350 per 100,000. By 2029, the averaged projected annual number of hip fractures is 10311, with an incidence rate of 463 per 100,000. The largest percentage increase in hip fracture occurs in the 70-79 age group (57%), with comparable increases in both sexes (30%). Based upon these projections, overall length of stay following hip fracture will increase from 142713 bed days per annum in 2021, to 203412 by 2029, incurring an additional cost of over £25 million.Forecast modelling demonstrates that the annual number of hip fractures in Scotland will rise substantially by 2029, with considerable implications for health and social care services.
Vistas y vivencias urbanas del París de 1900 en los aguafuertes de Joaquim Sunyer
Authors: Vives Piqué Maria Rosa 
Published: March 2023

Joaquim Sunyer (Sitges, 1874 -1956), pintor y grabador, destacó en esta última faceta con un amplio catálogo de grabados realizados en diferentes momentos de su trayectoria artística. Un período excepcional lo constituye la serie de grabados que hizo en plena juventud durante su estancia en París en los albores del siglo XX que, por mor de su alta calidad plástica, merecen ser observados con detenimiento.
En ellos representa diversas facetas de la vida urbana, vistas animadas que, todo y evocar un cierto tipismo, obvian los parámetros ilustrativos pintorescos. Sunyer plasma con visión altamente comprensiva tanto la sociedad bohemia como las clases medias y obreras, a veces, incluso marginadas, que transitan por la ciudad. La diversión en bailes y espectáculos, tertulias de estudiantes ociosos, paseantes, mercados ambulantes, lavanderas, obreros y una retahíla de personajes de larga prosapia iconográfica situados en entornos identificables, calles o plazas que a menudo dan nombre a la estampa: el parque del Luxembourg, calle Lepic, calle de Belleville, calle de la Lune, canal de Saint Martin..., donde se reconocen edificios y establecimientos, medios de transporte, pavimentos, alumbrado, etc., de manera que el conjunto constituye un particular repertorio testimonial del París de aquel entonces cotejable con fuentes literarias, fotográficas e incluso cinematográficas.
Aunque la fotografía y el cine ya eran los medios de captación documental de este tiempo y lugar, las estampas de Sunyer, sin abstraerse de la realidad, aúnan el documento con una romántica melancolía mediante una experimental y altamente expresiva ejecución al aguafuerte en color. Obviamente una creación artística no es un testimonio fehaciente de una realidad catastral o notarial, pero mediante el pálpito artístico que desprende se nos permite no sólo pensar y disfrutar de su fenomenología, sino también de unos particulares flases del Paris de la Belle Époque.­­­
Seasonal variation of diarrhoeal pathogens among Guinea-Bissauan children under five years of age
Authors: Mero Sointu , Lääveri Tinja , Ursing Johan , Rombo Lars , Kofoed Poul-Erik , Kantele Anu 
Published: March 2023

Background
Diarrhoea remains a major cause of childhood morbidity and mortality in low-income countries (LICs). The frequency of diarrhoeal episodes may vary by season, yet few prospective cohort studies have examined seasonal variation among various diarrhoeal pathogens using multiplex qPCR to analyse bacterial, viral and parasitic pathogens.

Methods
We combined our recent qPCR data of diarrhoeal pathogens (nine bacterial, five viral and four parasitic) among Guinea-Bissauan children under five years old with individual background data, dividing by season. The associations of season (dry winter and rainy summer) and the various pathogens were explored among infants (0–11 months) and young children (12–59 months) and those with and without diarrhoea.

Results
Many bacterial pathogens, especially EAEC, ETEC and Campylobacter, and parasitic Cryptosporidium, prevailed in the rainy season, whereas many viruses, particularly the adenovirus, astrovirus and rotavirus proved common in the dry season. Noroviruses were found constantly throughout the year. Seasonal variation was observed in both age groups.

Conclusion
In childhood diarrhoea in a West African LIC, seasonal variation appears to favour EAEC, ETEC, and Cryptosporidium in the rainy and viral pathogens in the dry season.
Patient visits and prescriptions for attention-deficit/hyperactivity disorder from 2017–2021: Impacts of COVID-19 pandemic in primary care
Authors: Butt Debra A. , Stephenson Ellen , Kalia Sumeet , Moineddin Rahim , Tu Karen 
Published: March 2023

Objective
To determine whether more patients presented with Attention-deficit/hyperactivity disorder (ADHD)-related visits and/or sought care from family physicians more frequently during the COVID-19 pandemic.

Methods
Electronic medical records from the University of Toronto Practice-Based Research Network were used to characterize changes in family physician visits and prescriptions for ADHD medications. Annual patient prevalence and visit rates pre-pandemic (2017–2019) were used to calculate the expected rates in 2020 and 2021. The expected and observed rates were compared to identify any pandemic-related changes.

Results
The number of patients presenting for ADHD-related visits during the pandemic was consistent with pre-pandemic trends. However, observed ADHD-related visits in 2021 were 1.32 times higher than expected (95% CI: 1.05–1.75), suggesting that patients visited family physicians more frequently than before the pandemic.

Conclusion
Demand for primary care services related to ADHD has continued to increase during the pandemic, with increased health service use among those accessing care.
Health facility readiness to provide antenatal care (ANC) and non-communicable disease (NCD) services in Nepal and Bangladesh: Analysis of facility-based surveys
Authors: Thapa Deependra K. , Acharya Kiran , Karki Anjalina , Cleary Michelle 
Published: March 2023

Background
Antenatal care (ANC) visits provide an important opportunity for diagnostic, preventive, and curative services for non-communicable diseases (NCDs) during pregnancy. There is an identified need for an integrated, system-wide approach to provide both ANC and NCD services to improve maternal and child health outcomes in the short and long term.

Objective
This study assessed the readiness of health facilities to provide ANC and NCD services in Nepal and Bangladesh, identified as low–and middle–income countries.

Method
The study used data from national health facility surveys in Nepal (n = 1565) and Bangladesh (n = 512) assessing recent service provision under the Demographic and Health Survey programs. Using the WHO’s service availability and readiness assessment framework, the service readiness index was calculated across four domains: staff and guidelines, equipment, diagnostic, and medicines and commodities. Availability and readiness are presented as frequency and percentages, while factors associated with readiness were examined using binary logistic regression.

Results
Of the facilities, 71% in Nepal, and 34% in Bangladesh reported offering both ANC and NCD services. The proportion of facilities which showed readiness for providing ANC and NCD services was 24% in Nepal and 16% in Bangladesh. Gaps in readiness were observed in the availability of trained staff, guidelines, basic equipment, diagnostics, and medicines. Facilities managed by the private sector or a Non-Governmental Organization, located in an urban area, with management systems to support the delivery of quality services were positively associated with readiness to provide both ANC and NCD services.

Conclusion
There is a need to strengthen the health workforce by ensuring skilled personnel, having policy, guidelines and standards, and that diagnostics, medicines, and commodities are available/provided in health facilities. Management and administrative systems are also required, including supervision and staff training, to enable health services to provide integrated care at an acceptable level of quality.
Poor outcomes among critically ill HIV-positive patients at hospital discharge and post-discharge in Guinea, Conakry: A retrospective cohort study
Authors: Albus Sebastian Ludwig , Harrison Rebecca E. , Moudachirou Ramzia , Nanan-N’Zeth Kassi , Haba Benoit , Casas Esther C. , Isaakidis Petros , Diallo Abdourahimi , Camara Issiaga , Doumbuya Marie , Sako Fode Bangaly , Cisse Mohammed 
Published: March 2023

Introduction
Optimal management of critically ill HIV-positive patients during hospitalization and after discharge is not fully understood. This study describes patient characteristics and outcomes of critically ill HIV-positive patients hospitalized in Conakry, Guinea between August 2017 and April 2018 at discharge and 6 months post-discharge.

Methods
We carried out a retrospective observational cohort study using routine clinical data. Analytic statistics were used to describe characteristics and outcomes.

Results
401 patients were hospitalized during the study period, 230 (57%) were female, median age was 36 (IQR: 28–45). At admission, 229 patients (57%) were on ART, median CD4 was 64 cells/mm3, 166 (41%) had a VL >1000 copies/ml, and 97 (24%) had interrupted treatment. 143 (36%) patients died during hospitalisation. Tuberculosis was the major cause of death for 102 (71%) patients. Of 194 patients that were followed after hospitalization a further 57 (29%) were lost-to-follow-up (LTFU) and 35 (18%) died, 31 (89%) of which had a TB diagnosis. Of all patients who survived a first hospitalisation, 194 (46%) were re-hospitalised at least once more. Amongst those LTFU, 34 (59%) occurred immediately after hospital discharge.

Conclusion
Outcomes for critically ill HIV-positive patients in our cohort were poor. We estimate that 1-in-3 patients remained alive and in care 6 months after their hospital admission. This study shows the burden of disease on a contemporary cohort of patients with advanced HIV in a low prevalence, resource limited setting and identifies multiple challenges in their care both during hospitalisation as well as during and after re-transitioning to ambulatory care.
Prevalence of abnormal uterine bleeding in Brazilian women: Association between self-perception and objective parameters
Authors: Rezende Gabriela Pravatta , Yela Gomes Daniela Angerame , Benetti-Pinto Cristina Laguna 
Published: March 2023

Introduction
Abnormal uterine bleeding (AUB) is the main cause of demand for gynecological care during the reproductive period, with negative consequences on women’s lives. In Brazil, data on the prevalence of AUB is scarce and does not reflect the national reality.

Objective
To evaluate the prevalence of AUB and associated factors in Brazil.

Methods
Multicenter cross-sectional study, including 8 centers representing the 5 official geographic regions of Brazil. It included postmenarchal women who answered a sociodemographic questionnaire, with socioeconomic stratum and data related to uterine bleeding (self-perception of AUB and objective data)

Results
1928 women were included, with 35.5±12.5 years of age, 167 postmenopausal. The 1761 women in their reproductive period, had a menstrual cycle duration of 29.2±20.6 days, with bleeding for 5.6±4.0 days. In these, the prevalence of AUB, considering self-perception by the women, was 31.4%. Only among women who considered their bleeding abnormal, the menstrual cycle lasted less than 24 days in 28.4%, bleeding lasted longer than 8 days in 21.8%, 34.1% reported intermenstrual bleeding and 12.8% reported postcoital bleeding. Also, regarding these women, 47% reported a previous diagnosis of anemia, with 6% requiring intravenous treatment (iron or blood transfusion). Half of the women mentioned that the menstrual period had a negative impact on quality of life, while this worsening occurs in about 80% of those with self-perception of AUB.

Conclusion
In Brazil, the prevalence of AUB is 31.4%, assessed by self-perception, in agreement with objective AUB parameters. The menstrual period has a negative impact on the quality of life of 8 out of 10 women with AUB.
The indelible toll of enteric pathogens: Prevalence, clinical characterization, and seasonal trends in patients with acute community-acquired diarrhea in disenfranchised communities
Authors: Osman Marwan , Kassem Issmat I. , Dabboussi Fouad , Cummings Kevin J. , Hamze Monzer 
Published: March 2023

BackgroundThere is little information on the epidemiology of enteric pathogens in Lebanon, a low- and middle-income country that suffers from a myriad of public health challenges. To address this knowledge gap, we aimed to assess the prevalence of enteric pathogens, identify risk factors and seasonal variations, and describe associations between pathogens among diarrheic patients in the Lebanese community.Methodology and principal findingsA multicenter cross-sectional community-based study was conducted in the north of Lebanon. Stool samples were collected from 360 outpatients suffering from acute diarrhea. Based on fecal examination using the BioFire®FilmArray®Gastrointestinal Panel assay, the overall prevalence of enteric infections was 86.1%. EnteroaggregativeEscherichia coli(EAEC) was the most frequently identified (41.7%), followed by enteropathogenicE.coli(EPEC) (40.8%) and rotavirus A (27.5%). Notably, two cases ofVibrio choleraewere identified, whileCryptosporidiumspp. (6.9%) was the most common parasitic agent. Overall, 27.7% (86/310) of the cases were single infections, and the majority, 73.3% (224/310), were mixed infections. Multivariable logistic regression models showed that enterotoxigenicE.coli(ETEC) and rotavirus A infections were significantly more likely to occur in the fall and winter compared to the summer. Rotavirus A infections significantly decreased with age but increased in patients living in rural areas or suffering from vomiting. We identified strong associations in the co-occurrence of EAEC, EPEC, and ETEC infections and a higher percentage of rotavirus A and norovirus GI/GII infections among EAEC-positive cases.ConclusionsSeveral of the enteric pathogens reported in this study are not routinely tested in Lebanese clinical laboratories. However, anecdotal evidence suggests that diarrheal diseases are on the rise due to widespread pollution and the deterioration of the economy. Therefore, this study is of paramount importance to identify circulating etiologic agents and prioritize dwindling resources to control them and limit outbreaks in the future.
APPROACHES TO ASSESSING THE EFFICIENCY OF THE REGIONAL INNOVATION SYSTEM FUNCTIONING
Authors: Akchulpanov Yu. K. 
Published: March 2023

The article reveals modern approaches to assessing the effectiveness of the region's innovation system, which take into account the peculiarities of the socio-economic development of territories. The factors that form the sustainability of the development of the region's economy are analyzed. The concept of the innovative potential of the region as the main element of assessing the effectiveness of the regional innovation system is considered. Approaches to the interpretation of the concept of “efficiency” are studied. The existing methods for evaluating the effectiveness of the functioning of innovative systems in the region are analyzed. The effectiveness of various socioeconomic systems and methods for determining economic efficiency are analyzed. An approach is presented to determine the effectiveness of the innovation system of the region in the conditions of modern economic relations, taking into account regional characteristics. Based on the presented approaches, the innovative activity in the Republic of Bashkortostan is analyzed.
The relevance of the study is determined by the need to accelerate the transition of the Russian economy to the path of technological development in the face of sanctions pressure from Western countries, restrictions on the supply of imported equipment and components. With the successful implementation of this policy, there is an opportunity for strategizing, adjusting and improving the efficiency of the economy. The above facts testify to the timeliness of research into the issues of the effectiveness of innovation activity. For effective management of innovation activities, a qualitative analysis of this area is necessary.
The Influence of National Culture on the Success or Failure of Multi-National IS Projects
Authors: Murphy Liam 
Published: March 2023

In the progressively globalising 21st century, information systems (IS) work is
increasingly taking place in a cross-cultural context, and the relational factor of
culture is now more important than ever given the adoption of numerous Internetbased
systems by organisations across the globe. However, despite this increasing
trend, we still have a limited understanding of how and why multi-national IS projects
succeed or fail, and the role that national culture has to play in this. This research poster summarises the results of a larger piece of research into this area.
Recovery From the Impact of COVID-19 on Treatment Times and Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction: An Interim Analysis
Authors: Ali Abdelrahman , Schirmer Thomas , Kiernan Francis J. , Piccirillo Bryan , Ingrassia Joseph , Azemi Talhat , Sadiq Immad , Fram Daniel B. , Rizvi Asad , Joshi Saurabh , Mather Jeffrey , McKay Raymond G. 
Published: March 2023

Abstract

Background
Previous studies have documented a negative impact of the COVID-19 pandemic on emergent percutaneous treatment of patients with ST-segment elevation myocardial infarction (STEMI), but few have examined recovery of healthcare systems in restoring prepandemic STEMI care.

Methods
Retrospective analysis was performed of data from 789 patients with STEMI from a large tertiary medical center treated with percutaneous coronary intervention between January 1, 2019, and December 31, 2021.

Results
For patients with STEMI presenting to the emergency department, median time from door to balloon was 37 minutes in 2019, 53 minutes in 2020, and 48 minutes in 2021 (P < .001), whereas median time from first medical contact to device changed from 70 to 82 to 75 minutes, respectively (P = .002). Treatment time changes in 2020 and 2021 correlated with median emergency department evaluation time (30 to 41 to 22 minutes, respectively; P = .001) but not median catheterization laboratory revascularization time. For transfer patients, median time from first medical contact to device changed from 110 to 133 to 118 minutes, respectively (P = .005). In 2020 and 2021, patients with STEMI had greater late presentation (P = .028) and late mechanical complications (P = .021), with nonsignificant increases in yearly in-hospital mortality (3.6% to 5.2% to 6.4%; P = .352).

Conclusion
COVID-19 was associated with worsening STEMI treatment times and outcomes in 2020. Despite improving treatment times in 2021, in-hospital mortality had not decreased in the setting of a persistent increase in late patient presentation and associated STEMI complications.
Paul Cobley’s impact on biosemiotics: Thomas Sebeok’s next century
Authors: Kull Kalevi 
Published: March 2023

AbstractWe briefly review the impact of Paul Cobley (born 1963) on biosemiotics and list his works on the topic. These have links to communication studies and integrationism. After Thomas Sebeok, John Deely, and several others, Cobley has been a leader of the general semiotics movement, according to which “semiotics’ project is most fully realized on a biosemiotic basis.”
Form, communication, meaning
Authors: Guerri Claudio F. 
Published: March 2023

Abstract
An interesting article by Hongbing Yu (Yu, Hongbing. 2019. Meaning generation. Chinese Semiotic Studies 15(3). 429–447) “Meaning generation” led me to reconsider an unpublished paper from 15 years ago on Roman Jakobson’s much-criticized basic communication model, and the functions of language published in the Closing Statement of Style in language (Jakobson, Roman. 1960. Linguistics and poetics. In Thomas Sebeok (ed.), Style in language, 350–377. New York: MIT Press). In this article it is about using the semiotic nonagon operative model, derived from the three Peircean categories, to review Jakobson’s model, and in turn, think about the limits of agency for the production of meaning in relation to three other authors like Jacques Lacan, Louis Althusser, and Charles S. Peirce himself.