bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptual integrality of foreign segmental and tonal information: Dimensional transfer hypothesis
Authors: Choi William , Tsui Rachel Ka-Ying 
Published: December 2022

AbstractThis study investigates whether (a) Cantonese and (b) English listeners integrally or independently perceive Thai tone and segmental information. Listeners completed a modified AX discrimination task that contained a control block (without segmental variation) and an orthogonal block (with segmental variation). Relative to their own performance in the control block, the Cantonese listeners showed increased response time, decreased proportion of accuracy, and decreased sensitivity index in the orthogonal block. By contrast, the English listeners showed similar response time, proportion of accuracy, and sensitivity index across the two blocks. These reflect integral processing among the Cantonese but not the English listeners. This finding motivates the dimensional transfer hypothesis. The hypothesis posits that L1 perceptual experience shapes the perceptual integrality (or nonintegrality) of foreign suprasegmental and segmental information.
Risk factors for Leptospira seropositivity in rural Northern Germany, 2019
Authors: Schmitz Saskia , Princk Christina , Meyer-Schlinkmann Kristin , Mylius Maren , Bier Nadja S. , Baillot Armin , Monazahian Masyar , Ulrich Rainer G. , Mayer-Scholl Anne , Dreesman Johannes 
Published: December 2022

Abstract
We investigated seroprevalence and factors associated with Leptospira spp. infections in humans in rural Northern Germany. Sera of 450 participants were tested for leptospira-reactive IgG antibodies by two enzyme-linked immunosorbent assays (ELISA). A narrow (specific) and a broad (sensitive) case definition were applied and results compared in the analysis. Personal data were collected via questionnaire and associations with the serostatus were investigated by multivariable logistic regression. The seroprevalence estimates were 1.6% (95%-confidence interval (CI) = 0.63–3.2) under the narrow and 4.2% (95%-CI = 2.6–6.5%) under the broad case definition. Few (14%) participants knew about the pathogen. No seropositive participant recalled a prior leptospirosis diagnosis. Spending more than two hours a week in the forest was significantly associated with anti-leptospira IgG in both models (broad case definition: adjusted odds ratio (aOR) = 2.8, 95%-CI = 1.2–9.1; narrow case definition: aOR = 11.1, 95%-CI = 1.3–97.1). Regular cleaning of storage rooms was negatively associated in the broad (aOR = 0.17, 95%-CI = 0.03–0.98) and touching a dead rodent in the past 10 years in the narrow case definition model (aOR = 0.23, 95%-CI = 0.05–1.04). Our findings support risk factors identified in previous investigations. To counter the low awareness for the pathogen, we recommend that health authorities communicate risks and preventive measures to the public by using target-group specific channels.
STRUCTURAL STABILITY OF MEANDERING-HYPERBOLIC GROUP ACTIONS
Authors: Kapovich Michael , Kim Sungwoon , Lee Jaejeong 
Published: December 2022

AbstractIn his 1985 paper, Sullivan sketched a proof of his structural stability theorem for differentiable group actions satisfying certain expansion-hyperbolicity axioms. In this paper, we relax Sullivan’s axioms and introduce a notion of meandering hyperbolicity for group actions on geodesic metric spaces. This generalization is substantial enough to encompass actions of certain nonhyperbolic groups, such as actions of uniform lattices in semisimple Lie groups on flag manifolds. At the same time, our notion is sufficiently robust, and we prove that meandering-hyperbolic actions are still structurally stable. We also prove some basic results on meandering-hyperbolic actions and give other examples of such actions.
Communication within families about advanced pediatric cancer: A qualitative study
Authors: Stanek Charis , Garcia Dana , Olsavsky Anna L. , Hill Kylie N. , Himelhoch Alexandra C. , Kenney Ansley E. , Humphrey Lisa , Olshefski Randal , Gerhardt Cynthia A. , Nahata Leena 
Published: December 2022

AbstractObjectivesThis qualitative study examined how families share information and feelings about advanced pediatric cancer from the perspective of both parents and children, as well as how these perspectives vary by child developmental stage.MethodsParticipants (24 mothers, 20 fathers, 23 youth [children and adolescents]) were from a larger longitudinal study at an academic pediatric hospital. Eligible youth had advanced cancer (physician-estimated prognosis of <60%, relapse, or refractory disease), were aged 5–19 years (>8 years old to participate independently), had an English-speaking parent, and lived within 140 miles of the hospital. Interviews were completed at enrollment and asked how families share information and emotions about the child’s cancer as a family.ResultsSaturation was reached at 20 interviews for mothers, fathers, and youth. Analyses revealed 4 major themes: (A) parents managing cancer-related information based on child age/developmental stage and processing styles of family members; (B) parents withholding poor prognosis information and emotions to maintain positivity; (C) lack of personal and familial emotion sharing; and (D) emotion sharing among their family and externally. Both parents and youth endorsed themes A, C, and D, but only parents endorsed theme B. Adolescents endorsed more themes than children. Parents of children (as opposed to adolescents) endorsed theme A more.Significance of resultsAlthough both parents and youth with advanced cancer were generally willing to talk about treatment, emotions were not consistently shared. Perspectives varied depending on the child’s developmental stage. Clinicians should assess parent and child information and emotion-sharing needs and provide individualized support to families regarding communication about advanced cancer.
A single case report of using Dummett’s systemic cognitive behavioural formulation to guide treatment of adolescent PTSD
Authors: O'Brien-Venus Bethany , Haines Cara 
Published: December 2022

Abstract
Trauma-focused CBT (TF-CBT) is recommended by NICE for adolescents with post-traumatic stress disorder (PTSD). Whilst caregiver involvement is recommended, no specific guidance on the nature of involvement is provided although it is important that involvement takes account of the nature of the trauma. This case report details how Dummett’s systemic CBT formulation was used to plan an intervention such that systemic sessions were included in TF-CBT treatment of an adolescent female with PTSD which arose following interpersonal trauma. Trauma symptoms, trauma cognitions and depressive symptoms were measured throughout, with trauma symptoms showing clinically significant change over the course of therapy. Clinical implications are considered regarding the applicability of systemic CBT formulation and the inclusion of systemic sessions within TF-CBT for adolescents whose traumas arose interpersonally.

Key learning aims

(1)
To be able to incorporate systemic factors into a formulation of the maintenance of PTSD for adolescents using Dummett’s systemic cognitive behavioural formulation.

(2)
To identify systemic interventions that may facilitate change in interactions between adolescents and parental figures and change in trauma appraisals.
Modulation Effects of Mesoscale Eddies on Sea Surface Wave Fields in the South China Sea Derived From a Wave Spectrometer Onboard the China‐France Ocean Satellite
Authors: Tan K. , Xie L. , Bai P. , Zheng Q. , Li J. , Xu Y. , Li M. 
Published: December 2022

AbstractThis study aims to examine the modulation effects of mesoscale eddies on sea surface wave fields in the South China Sea using data measured by a wave spectrometer named Surface Wave Investigation and Monitoring onboard the China‐France Ocean Satellite from July 2019 to August 2021. The statistical results show that the significant wave heights (SWHs) decrease (increase) from inside to outside of warm (cold) eddies, while the wavelengths have minimum values at the eddy edge in all cases. In cases of strong warm eddies, the maximum variations in SWH, wavelength, and wave direction caused by mesoscale eddy modulation reach up to 18%, 24%, and 28.4°, respectively. The eddy modulation on wave parameters is stronger at low sea states. The correlation analysis reveals that the wave parameter variations across eddies result from the eddy current shear and the direction difference between the eddy current and the waves. The dynamic analysis indicates that the deformation term of the eddy current is a dominant term affecting the SWH at the eddy edge, and the eddy current divergence and its product with wave direction determine the wavelength variation. The eddy vorticity deflects the wave direction by approximately 2°–3°, and the wave‐eddy angle and eddy‐modulated wind variation also contribute to the wave direction variation. The background current‐wave interaction is negligible in the eddy cases studied.
Symptoms of Performance Degradation During Multi‐Annual Drought: A Large‐Sample, Multi‐Model Study
Authors: Trotter Luca , Saft Margarita , Peel Murray C. , Fowler Keirnan J. A. 
Published: December 2022

AbstractHydrologic models are essential tools to understand and plan for the effect of changing climates; however, they underperform in transitory climate conditions. Existing research identifies models' inadequacy to perform during prolonged drought, but falls short on pinpointing which specific aspects of model performance are affected. We study five conceptual rainfall‐runoff models and their performance in 155 Australian catchments which recently experienced a 13‐year long drought. We use a wide range of performance metrics and a methodology based on ranked differences to a benchmark to fairly compare levels of degradation across metrics and periods. We show model performance degrading extensively during and after the drought, largely driven by overestimation of flow. Representation of shape and variability of hydrograph and flow‐duration curve are more resilient to the prolonged dry climate and rarely more degraded during the multi‐annual drought that on isolated dry years in the pre‐drought record. Conversely, volumetric error suffers from significant exacerbation over the multiple subsequent dry years. This indicates that catchment retention times and rates of storage depletion storage are significantly less affected by the drought than amounts of streamflow produced, pointing to a mismatch between reduction of influxes and out‐fluxes during the drought. We also identify a deficiency of models to delay and remove flow before it reaches the stream and keep track of moisture deficits over multiple dry seasons. By promoting rigorous investigation of models' shortcomings, we hope to foster the development of more robust model structures and/or calibration frameworks to improve applicability within climate change scenarios.
Wave Field Properties in Tropical Cyclones From the Spectral Observation of the CFOSAT/SWIM Spaceborne Instrument
Authors: Le Merle E. , Hauser D. , Yang C. 
Published: December 2022

AbstractTropical cyclones (TCs) are extreme events that generate, because of their movement, complex wave fields. The Surface Wave Investigation and Monitoring (SWIM) instrument is a real aperture radar that provides unprecedented detailed information about the waves with dominant wavelength between 70 and 500 m in all directions at the global scale. In this study we collocated 3 years of SWIM data with 67 TCs in the Northern Hemisphere to analyze the impact of the TC characteristics on the wave field. TCs have been classified into three different classes (slow, moderate speed, and fast) estimated based on the ratio between the maximum sustained wind and the displacement velocity. In order to analyze the characteristics of the wave field in the space domain, the observations have been separated according to the distance with the TC center and the quadrant. The results show that the characteristics of the TCs impact the wave field: the more favorable conditions for trapped wave phenomenon appears to be under moderate speed TC conditions. In slow and moderate speed TCs, close to the center the directional spectra are mono‐modal and tend to become bi‐ or multi‐modal when the distance to the center increases whereas in fast‐moving TCs, the directional spectra are always bi‐ or multi‐modal. Omni‐directional spectra show similarities with fetch‐limited spectra in slow and moderate speed TCs whereas in fast‐moving TCs, because of the presence of mixed‐sea, the decrease of energy with frequency is less steep than in fetch‐limited conditions.
Immunogenicity and risks associated with impaired immune responses following SARS-CoV-2 vaccination and booster in hematologic malignancy patients: an updated meta-analysis
Authors: Uaprasert Noppacharn , Pitakkitnukun Palada , Tangcheewinsirikul Nuanrat , Chiasakul Thita , Rojnuckarin Ponlapat 
Published: December 2022

AbstractPatients with hematologic malignancies (HM) have demonstrated impaired immune responses following SARS-CoV-2 vaccination. Factors associated with poor immunogenicity remain largely undetermined. A literature search was conducted using PubMed, EMBASE, Cochrane, and medRxiv databases to identify studies that reported humoral or cellular immune responses (CIR) following complete SARS-CoV-2 vaccination. The primary aim was to estimate the seroconversion rate (SR) following complete SARS-CoV-2 vaccination across various subtypes of HM diseases and treatments. The secondary aims were to determine the rates of development of neutralizing antibodies (NAb) and CIR following complete vaccination and SR following booster doses. A total of 170 studies were included for qualitative and quantitative analysis of primary and secondary outcomes. A meta-analysis of 150 studies including 20,922 HM patients revealed a pooled SR following SARS-CoV-2 vaccination of 67.7% (95% confidence interval [CI], 64.8–70.4%; I2 = 94%). Meta-regression analysis showed that patients with lymphoid malignancies, but not myeloid malignancies, had lower seroconversion rates than those with solid cancers (R2 = 0.52, P < 0.0001). Patients receiving chimeric antigen receptor T-cells (CART), B-cell targeted therapies or JAK inhibitors were associated with poor seroconversion (R2 = 0.39, P < 0.0001). The pooled NAb and CIR rates were 52.8% (95% CI; 45.8–59.7%, I2 = 87%) and 66.6% (95% CI, 57.1–74.9%; I2 = 86%), respectively. Approximately 20.9% (95% CI, 11.4–35.1%, I2 = 90%) of HM patients failed to elicit humoral and cellular immunity. Among non-seroconverted patients after primary vaccination, only 40.5% (95% CI, 33.0–48.4%; I2 = 87%) mounted seroconversion after the booster. In conclusion, HM patients, especially those with lymphoid malignancies and/or receiving CART, B-cell targeted therapies, or JAK inhibitors, showed poor SR after SARS-CoV-2 vaccination. A minority of patients attained seroconversion after booster vaccination. Strategies to improve immune response in these severely immunosuppressed patients are needed.
ABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL
Authors: Ma Xiaohong , Xia Min , Wei Lina , Guo Kui , Sun Rui , Liu Yao , Qiu Chunping , Jiang Jie 
Published: December 2022

AbstractEndometrial cancer is a common gynecological malignancy. With the onset of EC patients younger, conservative treatment with progesterone has become an important option for patients trying to preserve reproductive function. However, progesterone resistance is a key factor affecting the efficacy of therapy and it is urgent to clarify the mechanism so as to propose a potential target and inhibit the development of endometrial adenocarcinoma and progesterone resistance. MGLL, an important factor involved in lipid mobilization, is overexpressed in many tumors, however the biological function of MGLL in the development of endometrial adenocarcinoma and the process of progesterone resistance still remains unclear. In this study, we first found MGLL was highly expressed in progesterone resistant samples of endometrial adenocarcinoma, and then we verified its expression was increased in endometrial adenocarcinoma. Through in vitro and in vivo experiments, we demonstrated that overexpression of MGLL promoted tumor proliferation, metastasis and the occurrence of progestogen resistance, knockdown MGLL inhibited tumor proliferation, metastasis and reversed progestogen resistance. In addition, knockdown of MGLL can sensitize endometrial adenocarcinoma cells to progesterone, possibly by affecting ROS generation and reducing the expression of AKR1C1. Finally, it was verified that ABX-1431, MGLL inhibitor, reversed progesterone resistance and enhanced the sensitivity of endometrial adenocarcinoma to progesterone both in vitro and in vivo. In conclusion, the high expression of MGLL is involved in the occurrence and development of endometrial adenocarcinoma and progesterone resistance. Targeted inhibition of MGLL by inhibitors may be an effective method for the treatment of progesterone resistance in endometrial adenocarcinoma.
A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer
Authors: Maradonna Francesca , Fontana Camilla M. , Sella Fiorenza , Giommi Christian , Facchinello Nicola , Rampazzo Chiara , Caichiolo Micol , Hoseinifar Seyed Hossein , Dalla Valle Luisa , Van Doan Hien , Carnevali Oliana 
Published: December 2022

AbstractColon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in vitro studies reported anandamide’s (AEA) ability to block cancer cell proliferation and migration, but evidence from in vivo studies is still lacking. Thus, in this study, the effects of AEA exposure in zebrafish embryos transplanted with HCT116 cells were evaluated. Totally, 48 hpf xenografts were exposed to 10 nM AEA, 10 nM AM251, one of the cannabinoid 1 receptor (CB1) antagonist/inverse agonists, and to AEA + AM251, to verify the specific effect of AEA treatment. AEA efficacy was evaluated by confocal microscopy, which demonstrated that these xenografts presented a smaller tumor size, reduced tumor angiogenesis, and lacked micrometastasis formation. To gain deeper evidence into AEA action, microscopic observations were completed by molecular analyses. RNA seq performed on zebrafish transcriptome reported the downregulation of genes involved in cell proliferation, angiogenesis, and the immune system. Conversely, HCT116 cell transcripts resulted not affected by AEA treatment. In vitro HCT116 culture, in fact, confirmed that AEA exposure did not affect cell proliferation and viability, thus suggesting that the reduced tumor size mainly depends on direct effects on the fish rather than on the transplanted cancer cells. AEA reduced cell proliferation and tumor angiogenesis, as suggested by socs3 and pcnp mRNAs and Vegfc protein levels, and exerted anti-inflammatory activity, as indicated by the reduction of il-11a, mhc1uba, and csf3b mRNA. Of note, are the results obtained in groups exposed to AM251, which presence nullifies AEA’s beneficial effects. In conclusion, this study promotes the efficacy of AEA in personalized cancer therapy, as suggested by its ability to drive tumor growth and metastasis, and strongly supports the use of zebrafish xenograft as an emerging model platform for cancer studies.
TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9
Authors: Huang Huakun , Lu Qiuping , Ye Caihong , Wei Mengqi , Yang Chunmei , Zhang Lulu , Huang Yanran , Luo Xiaoji , Luo Jinyong 
Published: December 2022

AbstractBone morphogenetic protein 9 (BMP9), also named as growth differentiation factor 2 (GDF-2), is the strongest cytokine that promotes osteogenic differentiation in the BMP family, and has broad clinical application value. Nevertheless, the mechanism of BMP9 promotes osteogenic differentiation remain unclear. TAZ, a transcriptional co-activator, has great effects on cell proliferation, differentiation, and stem cell self-renewal. In this research, we investigated the effects of TAZ in BMP9-induced osteogenic differentiation of mesenchymal stem cell line C3H10T1/2 (MSCs) and murine multi-lineage cell lines C2C12 and MEFs (MMCs) and explored its possible mechanisms. This study has found that BMP9 induces the expression of TAZ and promotes its nuclear translocation. Meanwhile, our study found that Ad-TAZ and TM-25659, a TAZ agonist, can enhance the osteogenic differentiation of MSCs and MMCs induced by BMP9. Conversely, Ad-si-TAZ and verteporfin, an inhibitor of TAZ, have the contradictory effect. Likewise, the promotion of TAZ to the BMP9-induced ectopic bone formation in vivo was confirmed by the subcutaneous transplantation of MSCs in nude mice. Furthermore, we have detected that TAZ might increase the levels of the phosphorylation of Smad1/5/8, p38, ERK1/2, and JNK induced by BMP9. Additionally, we also found that TAZ increased the total protein level of β-catenin induced by BMP9. In summary, our results strongly indicated that TAZ will promote the osteogenic differentiation in MSCs and MMCs induced by BMP9 through multiple signal pathways.
A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients
Authors: Fu Zhe , Sun Huiling , Wu Yutong , Li Chao , Wang Yinglei , Liu Yixiang , Li Yilin , Nie Junxu , Sun Dandan , Zhang Yingxuan , Liu Naixin , Guo Kun , Yin Saige , Jia Qiuye , Yang Ying , He Li , Wang Ying , Yang Xinwang 
Published: December 2022

AbstractThe combined use of peptides, nanomaterials, and hydrogels is a promising strategy for chronic skin wound healing, which remains a huge clinical challenge. Here, we optimized the RL-QN15 peptide, which was shown to be a pro-healing drug candidate in our previous research, to obtain the cyclic heptapeptide (CyRL-QN15) with considerable therapeutic potency against skin wounds. Furthermore, a Zn2+-crosslinked sodium alginate (ZA) hydrogel containing hollow polydopamine (HPDA) nanoparticles loaded with CyRL-QN15 (HPDAlCyRL-QN15/ZA hydrogel) was prepared and characterized, which significantly enhanced the pro-healing potency of CyRL-QN15. At the cellular level, this nontoxic hydrogel accelerated the proliferation, migration, tube formation, and scratch healing of skin cells, regulated the secretion of cytokines from macrophages, directly scavenged free radicals, and decreased reactive oxygen species. Moreover, the HPDAlCyRL-QN15/ZA hydrogel significantly accelerated the healing of full-thickness skin wounds in type 2 diabetic mice by promoting the transition of macrophages to the M2 phenotype to reduce inflammation and cause re-epithelialization, formation of granulation tissue, deposition of collagen, and angiogenesis. Of note, the hydrogel also facilitated wound healing of diabetic patient skin cultured ex vivo. Overall, the HPDAlCyRL-QN15/ZA hydrogel presents a novel therapeutic strategy for clinical chronic skin wound (diabetic ulcer) healing.