bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Complex Lymphatic Drainage in Head and Neck Cutaneous Melanoma With Sentinel Lymph Node Biopsy Outcomes
Authors: Pasha Terouz , Arain Zohaib , Buscombe John , Aloj Luigi , Durrani Amer , Patel Animesh , Roshan Amit 
Published: March 2023

ImportanceAlthough sentinel lymph node biopsy (SLNB) is a vital staging tool, its application in head and neck melanoma (HNM) is complicated by a higher false-negative rate (FNR) compared with other regions. This may be due to the complex lymphatic drainage in the head and neck.ObjectiveTo compare the accuracy, prognostic value, and long-term outcomes of SLNB in HNM with melanoma from the trunk and limb, focusing on the lymphatic drainage pattern.Design, Setting, and ParticipantsThis cohort observational study at a single UK University cancer center included all patients with primary cutaneous melanoma undergoing SLNB between 2010 to 2020. Data analysis was conducted during December 2022.ExposuresPrimary cutaneous melanoma undergoing SLNB between 2010 to 2020.Main Outcomes and MeasuresThis cohort study compared the FNR (defined as the ratio between false-negative results and the sum of false-negative and true-positive results) and false omission rate (defined as the ratio between false-negative results and the sum of false-negative and true-negative results) for SLNB stratified by 3 body regions (HNM, limb, and trunk). Kaplan-Meier survival analysis was used to compare recurrence-free survival (RFS) and melanoma-specific survival (MSS). Comparative analysis of detected lymph nodes on lymphoscintigraphy (LSG) and SLNB was performed by quantifying lymphatic drainage patterns by number of nodes and lymph node basins. Multivariable Cox proportional hazards regression identified independent risk factors.ResultsOverall, 1080 patients were included (552 [51.1%] men, 528 [48.9%] women; median age at diagnosis 59.8 years), with a median (IQR) follow-up 4.8 (IQR, 2.7-7.2) years. Head and neck melanoma had a higher median age at diagnosis (66.2 years) and higher Breslow thickness (2.2 mm). The FNR was highest in HNM (34.5% vs 14.8% trunk or 10.4% limb, respectively). Similarly, the false omission rate was 7.8% in HNM compared with 5.7% trunk or 3.0% limbs. The MSS was no different (HR, 0.81; 95% CI, 0.43-1.53), but RFS was lower in HNM (HR, 0.55; 95% CI, 0.36-0.85). On LSG, patients with HNM had the highest proportion of multiple hotspots (28.6% with ≥3 hotspots vs 23.2% trunk and 7.2% limbs). The RFS was lower for patients with HNM with 3 or more affected lymph nodes found on LSG than those with fewer than 3 affected lymph nodes (HR, 0.37; 95% CI, 0.18-0.77). Cox regression analysis showed head and neck location to be an independent risk factor for RFS (HR, 1.60; 95% CI, 1.01-2.50), but not for MSS (HR, 0.80; 95% CI, 0.35-1.71).Conclusions and RelevanceThis cohort study found higher rates of complex lymphatic drainage, FNR, and regional recurrence in HNM compared with other body sites on long-term follow-up. We advocate considering surveillance imaging for HNM for high-risk melanomas irrespective of sentinel lymph node status.
ER+, HER2− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes
Authors: Chen Jessica W. , Jacot William , Cortés Javier , Krop Ian E. , Dent Susan , Harbeck Nadia , De Laurentiis Michelino , Diéras Véronique , Im Young‐Hyuck , Stout Thomas J. , Schimmoller Frauke , Savage Heidi M. , Hutchinson Katherine E. , Wilson Timothy R. 
Published: March 2023

Taselisib is a potent β‐sparing phosphatidylinositol 3‐kinase (PI3K) inhibitor that, with endocrine therapy, improves outcomes in phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA)‐mutated (PIK3CAmut) advanced breast cancer. To understand alterations associated with response to PI3K inhibition, we analysed circulating tumour DNA (ctDNA) from participants enrolled in the SANDPIPER trial. Participants were designated as either PIK3CAmut or PIK3CA no mutation was detected (NMD) per baseline ctDNA. The top mutated genes and tumour fraction estimates identified were analysed for their association with outcomes. In participants with PIK3CAmut ctDNA treated with taselisib + fulvestrant, tumour protein p53 (TP53; encoding p53) and fibroblast growth factor receptor 1 (FGFR1) alterations were associated with shorter progression‐free survival (PFS) compared to participants with NMD in these genes. Conversely, participants with PIK3CAmut ctDNA harbouring a neurofibromin 1 (NF1) alteration or high baseline tumour fraction estimate experienced improved PFS upon treatment with taselisib + fulvestrant compared to placebo + fulvestrant. Broadly, alterations in oestrogen receptor (ER), PI3K and p53 pathway genes were associated with resistance to taselisib + fulvestrant in participants with PIK3CAmut ctDNA. Altogether, we demonstrated the impact of genomic (co‐)alterations on outcomes with one of the largest clinico‐genomic datasets of ER+, HER2−, PIK3CAmut breast cancer patients treated with a PI3K inhibitor.
Two‐Photon Polymerization of Sugar Responsive 4D Microstructures
Authors: Ennis Alexa , Nicdao Deanna , Kolagatla Srikanth , Dowling Luke , Tskhe Yekaterina , Thompson Alex J. , Trimble Daniel , Delaney Colm , Florea Larisa 
Published: March 2023

AbstractStimuli‐responsive hydrogels have attracted much attention owing to the versatility of their programmed response in offering intelligent solutions for biomimicry applications, such as soft robotics, tissue engineering, and drug delivery. To achieve the complexity of biomimetic structures, two photon polymerization (2PP) has provided a means of fabricating intricate 3D structures from stimuli‐responsive hydrogels. Rapid swelling hydrogel microstructures are advantageous for osmotically driven stimuli‐response, where actuation speed, that is reliant on the diffusion of analytes or bioanalytes, can be optimized. Herein, the flexibility of 2PP is exploited to showcase a novel sugar‐responsive, phenylboronic acid‐based photoresist. This offers a remarkable solution for achieving fast response hydrogel systems that have been often hindered by the volume‐dependent diffusion times of analytes to receptor sites. A phenylboronic acid‐based photoresist compatible with 2PP is presented to fabricate stimuli‐responsive microstructures with accelerated response times. Moreover, microstructures with programmable actuation (i.e., bending and opening) are fabricated using the same photoresist within a one‐step fabrication process. By combining the flexibility of 2PP with an easily adaptable photoresist, an accessible fabrication method is showcased for sophisticated and chemo‐responsive 3D hydrogel actuators.
Toward the Practical and Scalable Fabrication of Sulfide‐Based All‐Solid‐State Batteries: Exploration of Slurry Process and Performance Enhancement Via the Addition of LiClO4
Authors: Jing Shenghao , Shen Huaqing , Huang Yuting , Kuang Wuqi , Zhang Zongliang , Liu Siliang , Yin Shuo , Lai Yanqing , Liu Fangyang 
Published: March 2023

AbstractSulfide‐based all‐solid‐state batteries (ASSBs) have a wide application prospect because of the advantages of higher energy density and better intrinsic safety over conventional lithium‐ion batteries (LIBs). The compatibility of sulfide‐based electrolytes with various organic solvents and the possibilities of the slurry coating process with these systems remain veiled that limits the large‐scale fabrication of sulfide‐based ASSBs. In this study, polyvinylidene fluoride (PVDF) binder and isobutyl isobutyrate (IBB) are selected as the combination of binder and solvent to achieve scalable slurry process after examining the chemical and electrochemical compatibility of Li6PS5Cl (LPSC) solid electrolyte, PVDF, and IBB. A comparative investigation of sheet‐type LiNi0.83Co0.11Mn0.06O2 (NCM811) electrodes and pellet‐type NCM811 electrodes shows that PVDF hinders the transport of Li+ and electron, but it benignantly works as a buffer layer, which alleviates the side reaction in the composite cathode electrode. Further, PVDF is modified by LiClO4 to facilitate interfacial Li+ transport, which improves the capacity retention of the cell at 0.5 C to 97.05% after 100 cycles. Finally, NCM811/graphite full‐cell is successfully fabricated by the slurry coating process, which demonstrates the feasibility of practical and scalable fabrication of sulfide‐based ASSBs with slurry process and its performance enhancement effect via LiClO4 modification.
In Situ Enzyme‐Induced Self‐Assembly of Antimicrobial‐Antioxidative Peptides to Promote Wound Healing
Authors: Teng Runxin , Yang Yuying , Zhang Zhuo , Yang Kexin , Sun Min , Li Chang , Fan Zhen , Du Jianzhong 
Published: March 2023

AbstractAntimicrobial peptides (AMPs) with dual intrinsic antibacterial and antioxidative functions have emerged as promising choice to cure infected wound. However, the most widely applied approach to endow AMPs with antioxidative function is to combine with antioxidative moieties, which may affect the spatial structure and physiological stability of AMPs. Herein, a new type of AMPs with inherent desired stability, antibacterial activity, and reactive oxygen species (ROS) scavenging is developed to effectively heal the infected wound. This formulation is in situ formed at wound site by tyrosinase‐triggered oxidation and self‐assembly of lyophilized antimicrobial peptide Trp‐Arg‐Trp‐Arg‐Trp‐Tyr, providing enhanced stability and a fourfold and sevenfold increasement in antibacterial efficiency against E. coli and S. aureus compared to peptide monomers. The antimicrobial peptide is first oxidized and then assembled into nanoparticles. The melanin‐like structure has been demonstrated with efficient antioxidant properties, and the experimental data show that peptide nanoparticles to scavenge superoxide radicals, hydroxyl radicals, and H2O2. In vivo experiments confirmed that peptide nanoparticles effectively heal infected wounds and obviously reduce ROS. Overall, the research provides a new approach to formulating antimicrobial peptides to treat wound with high healing efficiency.
Advances in Microgravity Directed Tissue Engineering
Authors: Cui Yi , Liu Weiyuan , Zhao Shuaijing , Zhao Yannan , Dai Jianwu 
Published: March 2023

AbstractTissue engineering aims to generate functional biological substitutes to repair, sustain, improve, or replace tissue function affected by disease. With the rapid development of space science, the application of simulated microgravity has become an active topic in the field of tissue engineering. There is a growing body of evidence demonstrating that microgravity offers excellent advantages for tissue engineering by modulating cellular morphology, metabolism, secretion, proliferation, and stem cell differentiation. To date, there have been many achievements in constructing bioartificial spheroids, organoids, or tissue analogs with or without scaffolds in vitro under simulated microgravity conditions. Herein, the current status, recent advances, challenges, and prospects of microgravity related to tissue engineering are reviewed. Current simulated‐microgravity devices and cutting‐edge advances of microgravity for biomaterials‐dependent or biomaterials‐independent tissue engineering to offer a reference for guiding further exploration of simulated microgravity strategies to produce engineered tissues are summarized and discussed.
Ultrabroadband Imaging Based on Wafer‐Scale Tellurene
Authors: Lu Jianting , He Yan , Ma Churong , Ye Qiaojue , Yi Huaxin , Zheng Zhaoqiang , Yao Jiandong , Yang Guowei 
Published: March 2023

AbstractHigh‐resolution imaging is at the heart of the revolutionary breakthroughs of intelligent technologies, and it is established as an important approach toward high‐sensitivity information extraction/storage. However, due to the incompatibility between non‐silicon optoelectronic materials and traditional integrated circuits as well as the lack of competent photosensitive semiconductors in the infrared region, the development of ultrabroadband imaging is severely impeded. Herein, the monolithic integration of wafer‐scale tellurene photoelectric functional units by exploiting room‐temperature pulsed‐laser deposition is realized. Taking advantage of the surface plasmon polaritons of tellurene, which results in the thermal perturbation promoted exciton separation, in situ formation of out‐of‐plane homojunction and negative expansion promoted carrier transport, as well as the band bending promoted electron–hole pair separation enabled by the unique interconnected nanostrip morphology, the tellurene photodetectors demonstrate wide‐spectrum photoresponse from 370.6 to 2240 nm and unprecedented photosensitivity with the optimized responsivity, external quantum efficiency and detectivity of 2.7 × 107 A W−1, 8.2 × 109% and 4.5 × 1015 Jones. An ultrabroadband imager is demonstrated and high‐resolution photoelectric imaging is realized. The proof‐of‐concept wafer‐scale tellurene‐based ultrabroadband photoelectric imaging system depicts a fascinating paradigm for the development of an advanced 2D imaging platform toward next‐generation intelligent equipment.
Blue Transparent OLEDs with High Stability and Transmittance for Modulating Sleep Disorders
Authors: Chae Hyeonwook , Park Yongjin , Jo Yehhyun , Jeon Yongmin , Lee Hyunjoo Jenny , Yoo Seunghyup , Choi Kyung Cheol 
Published: March 2023

AbstractOptoelectronics devices utilizing organic light‐emitting diodes (OLEDs) are emerging as new platforms for healthcare applications. In particular, wearable optoelectronics such as visual stimulus systems offer a distinctive advantage to intervene in and improve sleep disorders. In this study, two improvements are proposed for transparent OLEDs (TrOLEDs) that will be critical for visual applications. First, zinc sulfide with high surface energy and a high refractive index is explored as a seed and capping layer. An ultra‐thin silver cathode of 8 nm is demonstrated to be feasible in TrOLEDs, and luminous transmittance of 91% is achieved. Second, in general, achieving the operational stability of TrOLEDs with high transmittance is challenging due to the vulnerability of thin electrodes. By introducing a doping process to the electron transport layer, a lifetime comparable to that of control OLEDs with thick cathodes (>90%) is secured. Last, a preclinical model using blue light is proposed to modulate sleep patterns. Melanopsin is stimulated at the highest level of sleep desire, reducing non‐rapid eye movement sleep duration in mice by up to 14%. Based on these results, the proposed TrOLEDs are promising candidates for modulating sleep disorders such as insomnia and narcolepsy–cataplexy with the convenience of wearable form factors.
Photochemical Imaging of Near‐Field and Dissymmetry Factor in Chiral Nanostructures
Authors: Aoudjit Thinhinane , Horrer Andreas , Kostcheev Sergei , Bachelot Renaud , Plain Jérôme , Gérard Davy 
Published: March 2023

AbstractChiral nanostructures interact differently with right‐ or left‐handed circularly polarized light. Due to the lack of experimental approaches able to unveil the optical near‐field around chiral nanostructures, their optical characterization generally relies either on far‐field techniques or on numerical simulations. Here, a subwavelength imaging approach based on the interaction between the enhanced optical near‐field around chiral nanoparticles and an azobenzene molecular probe is reported. Under the action of light, the azobenzene molecules undergo isomerization cycles resulting in a measurable displacement of matter. The resulting imprint of the optical near‐field can then be imaged using atomic force microscopy. Using two shifted gold nanorods separated by a nanogap as a canonical chiral structure, a dissymmetry in the near‐field of the chiral structures under left and right circular polarizations is experimentally evidenced. Notably, it is observed that the gap mode is excited only when the handedness of the exciting light matches the handedness of the nanostructure, evidencing a chiral hot spot inside the gap. Moreover, it is shown that it is possible to experimentally map the near‐field dissymmetry factor, a quantity related to the local circular dichroism of the near‐field intensity.
Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging
Authors: Xie Chen , Wu Yue , Chau Ho‐Fai , Zhang Tao , Wong Carlos Tinlong , Yeung Yik‐Hoi , Lam Pak‐Lun , Bünzli Jean‐Claude G. , Charbonnière Loïc J. , Law Ga‐Lai , Wong Ka‐Leung 
Published: March 2023

AbstractBioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real‐time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)‐based complex is reported as a small‐molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights.
Full Complex‐Amplitude Engineering by Orientation‐Assisted Bilayer Metasurfaces
Authors: Deng Liangui , Li Zile , Guan Zhiqiang , Tao Jin , Li Gongfa , Zhu Xiaoli , Dai Qi , Fu Rao , Zhou Zhou , Yang Yan , Yu Shaohua , Zheng Guoxing 
Published: March 2023

AbstractOptical complex‐amplitude determines the propagation behavior of light in free space to the maximum extent. Precise control of complex‐amplitude is the key to generating user‐defined light fields. Current attempts to control optical complex‐amplitude using metasurface, however, either have limited amplitude/phase step numbers or lost high lateral resolution since amplitude and phase are usually manipulated with size‐varied nanostructures or several nanostructures integrated into a unit‐pixel. Here, it is shown that bilayer metasurface can readily decouple optical amplitude and phase, thus achieving arbitrary complex‐amplitude modulation only by arranging the orientation angles of nanostructures. In this design, each unit‐pixel in one layer has only one nanostructure with the same size, thus significantly increasing the lateral resolution of complex‐amplitude modulation. More importantly, the approach of controlling optical complex‐amplitude merely by changing nanostructure orientation can significantly simplify the metasurface design and aggrandize the fabrication tolerance, thus enhancing the robustness of metasurfaces toward practical applications.
Superflexible Inorganic Ag2Te0.6S0.4 Fiber with High Thermoelectric Performance
Authors: Fu Yanqing , Kang Shiliang , Gu Hao , Tan Linling , Gao Chengwei , Fang Zaijin , Dai Shixun , Lin Changgui 
Published: March 2023

AbstractFiber‐based inorganic thermoelectric (TE) devices, owing to the small size, light‐weight, flexibility, and high TE performance, are promising for applications in flexible thermoelectrics. Unfortunately, current inorganic TE fibers are strictly constrained by limited mechanical freedom because of the undesirable tensile strain, typically limited to a value of 1.5%, posing a strong obstacle for further application in large‐scale wearable systems. Here, a superflexible Ag2Te0.6S0.4 inorganic TE fiber is demonstrated that provides a record tensile strain of 21.2%, such that it enables various complex deformations. Importantly, the TE performance of the fiber shows high stability after ≈1000 cycles of bending and releasing processes with a small bending radius of 5 mm. This allows for the integration of the inorganic TE fiber into 3D wearable fabric, yielding a normalized power density of 0.4 µW m−1 K−2 under the temperature difference of 20 K, which is approaching the high‐performance Bi2Te3‐based inorganic TE fabric and is nearly two orders of magnitude higher than the organic TE fabrics. These results highlight that the inorganic TE fiber with both superior shape‐conformable ability and high TE performance may find potential applications in wearable electronics.
Reinforcing Native Solid‐Electrolyte Interphase Layers via Electrolyte‐Swellable Soft‐Scaffold for Lithium Metal Anode
Authors: Bae Jaehyeong , Choi Keonwoo , Song Hyunsub , Kim Do Heung , Youn Doo Young , Cho Su‐Ho , Jeon Dogyeong , Lee Jiyoung , Lee Junyoung , Jang Wontae , Lee Changhyeon , Kim Youson , Kim Chanhoon , Jung Ji‐Won , Im Sung Gap , Kim Il‐Doo 
Published: March 2023

AbstractThe lithium metal anode is notoriously unstable and reactive to electrolytes, forming brittle solid‐electrolyte interphase (SEI) layers with uneven distribution, exacerbating Li dendrites that ultimately limit the battery life. Here, this work passivates Li metal with electrolyte‐swellable polymer nanolayers deposited monolithically by the initiated chemical vapor deposition (iCVD) to reinforce the native SEI layers and stabilize their interface. The 100 nm iCVD poly(dimethylaminomethyl styrene) (pDMAMS) layer is swelled by 264% under a carbonate electrolyte, establishing the electrolyte‐filled soft scaffold for Li‐ion transport. Notably, the solvogel accommodates homogeneous Li2O‐free and Li2CO3‐rich native SEI layers, providing a record‐high Li‐ion transference number of 0.95 and ionic conductivity of 6.54 mS cm−1. The developed pDMAMS‐Li anodes extend the cycle life by 550% in Li–Li symmetric cells and 600% in LiNi0.6Mn0.2Co0.2O2 full cells compared to pristine Li metal. The mechanistic details of the swollen‐soft‐scaffold strategy are elucidated by depth profile analysis of the pDMAMS homopolymer compared to pDMAMS/electrolyte‐phobic copolymers, providing new insights to manage the interface of liquid‐state electrolyte and solid‐state Li metal by using a novel class of bifunctional solvogel.
Electronic and Lattice Engineering of Ruthenium Oxide towards Highly Active and Stable Water Splitting
Authors: Hou Liqiang , Li Zijian , Jang Haeseong , wang Yu , Cui Xuemei , Gu Xiumin , Kim Min Gyu , Feng Ligang , Liu Shangguo , Liu Xien 
Published: March 2023

AbstractThe development of efficiently active and stable bifunctional noble‐metal‐based electrocatalysts toward overall water splitting is urgent and challenging. In this work, a rutile‐structured ruthenium‐zinc solid solution oxide with oxygen vacancies (Ru0.85Zn0.15O2‐δ) is developed by a simple molten salt method. With naturally abundant edges of ultrasmall nanoparticles clusters, Ru0.85Zn0.15O2‐δ requires ultralow overpotentials, 190 mV for acidic oxygen evolution reaction (OER) and 14 mV for alkaline hydrogen evolution reaction (HER), to reach 10 mA cm−2. Moreover, it shows superior activity and durability for overall water splitting in different electrolytes. Experimental characterizations and density functional theory calculations indicate that the incorporation of Zn and oxygen vacancies can optimize the electronic structure of RuO2 by charge redistribution, which dramatically suppresses the generation of soluble Rux>4 and allows optimized adsorption energies of oxygen intermediates for OER. Meanwhile, the incorporation of Zn can distort local structure to activate the dangling O atoms on the distorted Ru0.85Zn0.15O2‐δ as proton acceptors, which firmly bonds the H atom in H2O* to stabilize the H2O and considerably improves the HER activity.