bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohort
Authors: Christensen Grace M. , Li Zhenjiang , Liang Donghai , Ebelt Stefanie , Gearing Marla , Levey Allan I. , Lah James J. , Wingo Aliza P. , Wingo Thomas S. , Huels Anke 
Published: April 2023

AbstractIntroductionHigher fine particulate matter (PM2.5) exposure has been found to be associated with Alzheimer’s disease (AD). PM2.5has been hypothesized to cause inflammation and oxidative stress in the brain, contributing to neuropathology. A major genetic risk factor of AD, the apolipoprotein E (APOE) gene, has also been hypothesized to modify the association between PM2.5and AD. However, little prior research exisits to support these hypotheses. Therefore, this paper aims to investigate the association between traffic-related PM2.5and AD hallmark pathology, including effect modification byAPOEgenotype, in an autopsy cohort.MethodsBrain tissue donors enrolled in the Emory Goizueta Alzheimer’s Disease Research Center (ADRC) who died before 2020 (n=224) were assessed for AD pathology including Braak Stage, Consortium to Establish a Registry for AD (CERAD) score, and the combined AD neuropathologic change (ABC score). Traffic-related PM2.5concentrations were modeled for the metro-Atlanta area during 2002-2019 with a spatial resolution of 200-250m. One-, 3-, and 5-year average PM2.5concentrations prior to death were matched to participants home address. We assessed the association between traffic-related PM2.5and AD hallmark pathology, as well as effect modification byAPOEgenotype, using adjusted ordinal logistic regression models.ResultsTraffic-related PM2.5was significantly associated with CERAD score for the 1-year exposure window (OR: 1.92; 95% CI: 1.12, 3.30), and the 3-year exposure window (OR: 1.87; 95%-CI: 1.01, 3.17). PM2.5had harmful, but non-significant associations on Braak Stage and ABC score. The strongest associations between PM2.5and neuropathology markers were among those withoutAPOEε4alleles (e.g., for CERAD and 1-year exposure window, OR: 2.31; 95% CI: 1.36, 3.94), though interaction between PM2.5andAPOEgenotype was not statistically significant.ConclusionsOur study found traffic-related PM2.5exposure was associated with CERAD score in an autopsy cohort, contributing to epidemiologic evidence that PM2.5affects Aβ deposition in the brain. This association was particularly strong among donors withoutAPOEε4alleles. Future studies should further investigate the biological mechanisms behind this assocation.
A scoping literature review of global dengue age-stratified seroprevalence data: estimating dengue force of infection in endemic countries
Authors: Vicco Anna , McCormack Clare , Pedrique Belen , Ribeiro Isabela , Malavige Gathsaurie Neelika , Dorigatti Ilaria 
Published: April 2023

AbstractDengue poses a significant burden worldwide, and a more comprehensive understanding of the heterogeneity in the intensity of dengue transmission within endemic countries is necessary to evaluate the potential impact of public health interventions.This scoping literature review aimed to update a previous study of dengue transmission intensity by collating global age-stratified dengue seroprevalence data published in the Medline and Embase databases from 2014 to 2022. These data were then utilized to calibrate catalytic models and estimate the force of infection (FOI), which is the yearly per-capita risk of infection for a typical susceptible individual.We found a total of 44 new publications containing 47 relevant datasets across 20 endemic countries. Together with the previously available average FOI estimates, there are now 280 dengue average FOI estimates obtained from seroprevalence data and 149 estimates obtained from case-notification data available across the world.The results showed large heterogeneities in average dengue FOI both across and within countries. These new estimates can be used to inform ongoing modelling efforts to improve our understanding of the drivers of heterogeneity in dengue transmission globally, which in turn can help inform the optimal implementation of public health interventions.Author summaryIn this work, we conducted a scoping literature review to collate global dengue age-specific seroprevalence data from dengue endemic areas published between 2014 and 2022. These data were used to calibrate mathematical models and estimate the average yearly force of infection (FOI), which is a fundamental measure of transmission intensity. FOI estimates can be used to quantify the risk of infection, disease burden and the potential impact of new interventions, such as vaccination.In addition, the FOI estimates generated in this study contribute to ongoing efforts to better characterise and map dengue transmission intensity worldwide.
DIPA-CRISPR gene editing in the yellow fever mosquitoAedes aegypti(Diptera: Culicidae)
Authors: Shirai Yu , Takahashi Momoyo , Ote Manabu , Kanuka Hirotaka , Daimon Takaaki 
Published: April 2023

AbstractCurrent methods for gene editing in insects rely on embryonic microinjection, which can be challenging for non-specialist laboratories. Recently, an alternative method known as “direct parental” CRISPR (DIPA-CRISPR) was developed. This method involves injecting commercial Cas9 protein and single-guide RNA into adult females, which can efficiently introduce mutations into developing oocytes. However, its versatility has not been fully explored, particularly in insects that have the most derived, polytrophic meroistic ovaries. In this study, we successfully applied DIPA-CRISPR to the yellow fever mosquitoAedes aegypti, which has polytrophic meroistic ovaries. Following adult injection of Cas9 ribonucleoproteins (Cas9 RNPs) targeting the kynurenine 3-monooxygenase gene, we recovered gene-edited G0individuals. Injection at 24 h after blood-feeding resulted in the highest gene editing efficiency (3.5%), confirming that a key parameter of DIPA-CRISPR is the stage in which the adult females are injected. Together with our previous study, we demonstrated that DIPA-CRISPR is applicable to all three types of insect ovaries (i.e., panoistic, telotrophic, and polytrophic), which indicates that DIPA-CRISPR is a generalizable approach for insect gene editing.
New platform and new excitement? Exploring young educated sport customers' perceptions of watching live sports on OTT services
Authors: Xu Maowei , Li Bo , Scott Olan K.M. , Wang Jerred Junqi 
Published: April 2023

PurposeThis study aims to investigate how sports customers adopted over-the-top (OTT) services to consume sport content. Inspired by the technology acceptance model (TAM), the study aims to understand users' behavior when consuming sporting events and users' perceptions toward OTT services.Design/methodology/approachThe participants of the study are Chinese sports consumers that use streaming services to watch live sport content. An online survey was distributed through HUPU Sports, a Chinese online communication community where sports fans can share opinions. To make sure all responses qualified to take part in the study, skip logic questions were added at the beginning of the questionnaire to ask participants to answer whether they used streaming services for watching sports. A total of 352 responses were received and there were 327 useable questionnaires.FindingsThe results revealed that viewing convenience, free of commercials and viewing quality were the main reasons impacting them to adopt OTT services. In terms of users' perceptions, paid users rated higher in perceived enjoyment, perceived value, perceived usefulness (PU) and ease of use than nonpaid users. OTT users' fandom and PU could predict the time the users spent on using these services, while the users' fandom and perceived value are positively related to the money users spent on these services. In addition, this study also found that users' fandom, perceived value, content quality, and ease of use are positively associated with users' intention to continue to use the service.Originality/valueThe study is one of the first attempts to explore how sports audiences adopted OTT services to consume sport content and explore the audiences' perceptions toward OTT usage. Previous studies have already investigated how users adopted music streaming services (Fernandes and Guerra, 2019) and other online streaming services (Shin and Park, 2021), but little attention has been given to sports streaming services specifically. Therefore, the findings of the study fill the gap in the extant knowledge of sport consumers' behavior and provide more insights to their online behaviors. Moreover, the authors also contribute to the growing digital media literature by advancing our understanding perceptional differences between paid users and unpaid users. The streaming services literature has primarily focused on general users (Fernandes and Guerra, 2019), but the services neglect to understand the differences in between paid and unpaid users.
Achieving software development agility: different roles of team, methodological and process factors
Authors: Rathor Shekhar , Xia Weidong , Batra Dinesh 
Published: April 2023

PurposeAgile principles have been widely used in software development team practice since the creation of the Agile Manifesto. Studies have examined variables related to agile principles without systematically considering the relationships among key team, agile methodology, and process variables underlying the agile principles and how these variables jointly influence the achievement of software development agility. In this study, the authors tested a team/methodology–process–agility model that links team variables (team autonomy and team competence) and methodological variable (iterative development) to process variables (communication and collaborative decision-making), which are in turn linked to software development agility (ability to sense, respond and learn).Design/methodology/approachSurvey data from one hundred and sixty software development professionals were analyzed using structural equation modeling methods.FindingsThe results support the team/methodology–process–agility model. Process variables (communication and collaborative decision-making) mediated the effects of team (autonomy and competence) and methodological (iterative development) variables on software development agility. In addition, team, methodology and process variables had different effects on the three dimensions of software development agility.Originality/valueThe results contribute to the literature on organizational IT management by establishing a team/methodology–process–agility model that can serve as a basis for developing a core theoretical foundation underlying agile principles and practices. The results also have practical implications for organizations in understanding and managing holistically the different roles that agile methodological, team and process factors play in achieving software development agility.
Toward a comprehensive model for talent identification of faculty members: a qualitative study for regional universities
Authors: Romiani Yones , Farahbakhsh Saeed 
Published: April 2023

PurposeThis study aimed to develop a model for identifying talented faculties in regional universities.Design/methodology/approachIn this study, the systematic grounded theory (GT) approach has been used. The research population consisted of academic and scientific experts of higher education system who had more knowledge about the subject of the research. They were identified and selected using a non-probability and purposeful sampling method.FindingsThe paper introduces a talent-based model for identifying faculties in regional universities. Findings show that in regional universities, talent management (TM) theory is rarely used to identify scientific talents. Therefore, to attract capable faculty members, using a comprehensive model based on this concept can be effective and efficient. To achieve the above goal, it is suggested that universities and higher education centers should pay special attention to the components of education, research and counseling when identifying faculty.Originality/valueThis article develops the knowledge about TM in higher education. Given the gap between theory and practice regarding the theory of TM in higher education, this study, with a look at the identity and nature of universities, offers recommendations for attracting faculty members. Implementing the desired model in regional universities gives them the assurance that by attracting capable people, it will be possible to achieve the university development plan.
The effect of IoT capability on supply chain integration and firm performance: an empirical study in the UK retail industry
Authors: Argyropoulou Maria , Garcia Elaine , Nemati Soheila , Spanaki Konstantina 
Published: April 2023

PurposeThe purpose of this study is to use empirical data to examine the hierarchical impact of the Internet of things capability on supply chain integration (SCI), supply chain capability (SCC) and firm performance (FP) in the UK retail industry.Design/methodology/approachA deductive approach was employed to carry out this research. Structural equation modelling (SEM) was performed using the partial least square method (SmartPLS 3.3.3) to test theoretical predictions which underlie the relationships among Internet of things capability (IoTC), SCI, SCC and FP. Data are collected using an online survey completed by senior executives of 66 large, medium and small firms within the UK retail industry.FindingsThe empirical results of this research reveal that IoTC has a significant positive effect on the UK retail industry FP through the mediating role of SCI and SCC.Practical implicationsThe research results from this study provide useful management insights for firms within the retail industry into the development of effective strategies for integrating their supply chain alongside the adoption of IoTC into SCI, consequently leading to improvements in FP.Originality/valueAlthough previous studies have explored the impact of IoT on FP through the sequential mediating role of SCI and SCC, few have explored the impact of the IoT capability (IoTC) on FP through sequential mediators, i.e. SCI and SCC. This study examines the relationship between IoTC, SCI, SCC and FP in the UK retail industry supply chain to address this knowledge gap. Moreover, this study examines the effects of IoTC on FP by applying partial least square (PLS)-SEM techniques. Testing the sequential mediating role of SCI and SCI is undertaken, and the relationships among IoT-enabled SCI and SCC is analysed to improve FP. The robustness check's result through PLSpredict analysis also confirms the power of the model proposed in this study.
Co-creating and evaluating social marketing programs: a living lab approach
Authors: Saleme Pamela , Dietrich Timo , Pang Bo , Parkinson Joy 
Published: April 2023

Purpose
This paper presents a methodological analysis of the co-creation and evaluation of “Biobot Academy” social marketing program to promote socio-emotional skills and prosocial behaviour in children, using a Living Lab method. This paper aims to identify how using a Living Lab method can enhance the co-creation and evaluation of a gamified social marketing program with users and stakeholders. To the best of the authors’ knowledge, this paper is the first to apply and further develop a Living Lab framework to guide social marketing program design.

Design/methodology/approach
Using a case study method, the Living Lab process was applied during the development of the gamified social marketing program for promoting socio-emotional skills and prosocial behaviour in children. In total, 28 online and in-person sessions over a two-year period led to program co-creation. Guided by a mixed method approach, testing was conducted in a non-randomised waitlist control trial, while qualitative data from in-game data capture, classroom observations and recordings were collected.

Findings
The application of the Living Lab method warranted improvements, specifically to the front-end and back-end steps of the existing process. While the non-randomised trial indicated effectiveness of the social marketing program across all outcome measures (self-awareness, empathy and prosocial behaviour intentions) compared to control, qualitative findings showed program improvements were needed on three specific aspects, namely, interactivity, user experience and comprehension.

Originality/value
This study provides methodological guidance for the application of the Living Lab method in other social marketing settings to help co-create innovative social marketing solutions with diverse stakeholder groups.
Heterogeneity identification method for surrounding rock of large-section rock tunnel faces based on support vector machine
Authors: Yi Wenhao , Wang Mingnian , Tong Jianjun , Zhao Siguang , Li Jiawang , Gui Dengbin , Zhang Xiao 
Published: April 2023

PurposeThe purpose of the study is to quickly identify significant heterogeneity of surrounding rock of tunnel face that generally occurs during the construction of large-section rock tunnels of high-speed railways.Design/methodology/approachRelying on the support vector machine (SVM)-based classification model, the nominal classification of blastholes and nominal zoning and classification terms were used to demonstrate the heterogeneity identification method for the surrounding rock of tunnel face, and the identification calculation was carried out for the five test tunnels. Then, the suggestions for local optimization of the support structures of large-section rock tunnels were put forward.FindingsThe results show that compared with the two classification models based on neural networks, the SVM-based classification model has a higher classification accuracy when the sample size is small, and the average accuracy can reach 87.9%. After the samples are replaced, the SVM-based classification model can still reach the same accuracy, whose generalization ability is stronger.Originality/valueBy applying the identification method described in this paper, the significant heterogeneity characteristics of the surrounding rock in the process of two times of blasting were identified, and the identification results are basically consistent with the actual situation of the tunnel face at the end of blasting, and can provide a basis for local optimization of support parameters.
A systematic evaluation on the competencies of construction supervisors in productivity and performance improvement practices – Sri Lankan perspective
Authors: Manoharan Kesavan , Dissanayake Pujitha , Pathirana Chintha , Deegahawature Dharsana , Silva Renuka 
Published: April 2023

PurposeA rise in productivity is associated with higher profits, competitiveness and the sustainability of an industry and a nation. Recent studies highlight inadequate labour supervision and training facilities as the main causes of productivity-related challenges among construction enterprises. This study aims to evaluate the construction supervisors' capabilities in applying the required elements of work practices for enhancing the performance and productivity of construction operations using a case study.Design/methodology/approachA new construction supervisory training programme was developed through comprehensive sequential processes, and 64 construction supervisors underwent training . Marking guides with different levels of descriptions/standards were developed through consultations with experts and literature reviews, and the supervisors' capabilities were assessed under 64 competency elements of 12 competency units.FindingsThe findings show a clear cross-section of all the required competencies of construction supervisors with various levels of standards/descriptions, leading to a new generalised guideline that helps to comprehend what degrees of skills can be taken into account in supervision attributes. Statistical tests and expert reviews were used to ensure the generalisability of the research applications and the reliability of the results.Research limitations/implicationsDespite the study findings being limited to the Sri Lankan construction industry, its applicability could create considerable impacts on the current/future practices of the construction sector in developing countries as well as other developing industries.Practical implicationsThe study adds new characteristics and values to construction supervision practices that can be remarkable in encouraging construction supervision to drive the sustainability of construction practices. The study findings are significant in decision-making/planning procedures related to technical comprehension, industry training, scientific documentation, adherence to workforce employment constraints and job outputs. This paper describes the further extensive implications and future scopes of the study elaborately.Originality/valueThis study addresses the knowledge gap in the industry related to the development of protocols and application methodologies necessary to track their performance. The study opens a new window that inflows knowledge attributes to the industry sector along with the necessary comparison of the relevant competency elements to predict/comprehend what levels of capabilities can be theoretically considered and practically applied in supervision characteristics.
Contemporaneous dependence between euro, crude oil, and gold returns and their respective implied volatility changes. Evidence from the local Gaussian correlation approach
Authors: Fousekis Panos 
Published: April 2023

Purpose
This study aims to assess the contemporaneous dependence between euro, crude oil and gold returns and their respective implied volatility changes.

Design/methodology/approach
The empirical analysis relies on daily data for the period 2015–2022 and the local Gaussian correlation (LGC) approach that is suitable for estimating dependence between two stochastic processes at any point of their joint distribution.

Findings
(a) The global correlation coefficients are negative for the euro and crude oil and positive for gold, implying that in the first two markets’ traders are more concerned with sudden price downswings while in the third with sudden upswings. (b) The detailed local analysis, however, shows that traders 2019 attitudes may change with the underlying state of the market and that risk reversals are more likely to occur at the upper extremes of the joint distributions. (c) The pattern of dependence between price returns and implied volatility changes is asymmetric.

Originality/value
To the best of the author’s knowledge, this is the first work that uses the highly flexible LGC approach to analyze the link between price returns and implied volatility changes either in stock or in commodities futures markets. The empirical results provide useful insights into traders’ risk attitudes in different market states.