bluuebunny/crossref_metadata_2025_split huggingface dataset:
WYKORZYSTANIE PROGRAMÓW KOMPUTEROWYCH W PRACY EDUKACYJNO-TERAPEUTYCZNEJ Z DZIECKIEM ZE SPEKTRUM AUTYZMU
Authors: Czarnecka Martyna , Zelazkowska Mariola 
Published: September 2023

Obecnie interakcje społeczne często realizowane są poprzez pocztę elektroniczną czy różnorodne komunikatory. Rozwiązania te stanowią ułatwienie dla osób, którym kontakt wzrokowy czy bezpośrednia rozmowa sprawiają trudności. Rozwój technologii dostarcza osobom ze spektrum autyzmu wiele możliwości do prawidłowego rozwoju, ale równocześnie niesie ryzyko pewnych ograniczeń w codziennych relacjach. Wykorzystanie programów komputerowych w terapii z dzieckiem ze spektrum autyzmu pomaga pedagogom w bieżącej pracy, pozwala uczniów w sposób atrakcyjny zrozumieć prezentowane treści.
W niniejszej publikacji autorki będą chciały odnieść się do kwestii stosowania w pracy edukacyjno-terapeutycznej z dziećmi ze spektrum autyzmu programów komputerowych. Idea korzystania z nich zapewnia dziecku wielowymiarowe wsparcie, między innymi w obszarze rozwoju językowego, poznawczego czy emocjonalnego. Autorki wskażą także pozytywne i negatywne aspekty wykorzystania tych technologii w terapii autyzmu.
Acupuncture Improves Synaptic Plasticity of SAMP8 Mice through the
RhoA/ROCK Pathway
Authors: Kan Bohong , Dong Zhengjia , Tang Zhenyu , Zhao Lan , Li Zhen 
Published: September 2023

Background:
Studies have found synaptic plasticity damage to be an early marker of
Alzheimer's disease (AD). RhoA/ROCK pathway is involved in the regulation of synaptic plasticity.
Acupuncture can significantly improve the cognitive state of AD.

Objective:
We aimed to use modern biological technology to detect the changes in synaptic plasticity
and RhoA/ROCK pathway in SAMP8 mice, as well as the intervention effect of acupuncture.

Methods:
Morris water maze and electrophysiological techniques were used in vivo to detect the
changes in spatial memory and LTP of mice. Golgi Cox staining and CASEVIEWER2.1 software
were used to quantitatively analyze the changes in the morphology and number of dendritic spines
in the hippocampus of mice. The activity of RhoA and ROCK2 in the hippocampus of mice was detected,
respectively, by pull-down technique and ELISA. WB technique was used to detect the protein
expression of ROCK2 and phosphorylation level of MLC2, LIMK2, and CRMP2 in the hippocampus
of mice.

Results:
The neurobehavior and synaptic plasticity of 8-month-old SAMP8 mice were found to be
significantly impaired. Acupuncture could improve the spatial learning and memory ability of
SAMP8 mice, and partially prevent the reduction in the number of spines on the secondary branches
of the apical dendrites in the hippocampus and the attenuation of LTP. The RhoA/ROCK pathway
was significantly activated in the hippocampus of 8-month-old SAMP8 mice, and acupuncture
had an inhibitory effect on it.

Conclusion:
Acupuncture can improve synaptic plasticity by inhibiting the abnormal activation of
the RhoA/ROCK pathway, and improve the spatial learning and memory ability of AD, so as to
achieve the purpose of treating AD
Anti-tumor Mechanism of Camellia nitidissima Based on Network Pharmacology and Molecular Docking
Authors: Wang Jun , Cheng Jingjing 
Published: September 2023

Background:
Modern pharmacological research indicated that Camellia nitidissima (CAM) had significant anti-tumor activity, but the investigation of its mechanism was still lacking.

Objective:
The multi-component, multi-target and multi-pathway mechanism of CAM against tumor was investigated based on network pharmacology and molecular docking.

Methods:
The active ingredients and targets of CAM were selected through a literature search, Traditional Chinese Medicine Systems Pharmacology database and PharmMapper database, and tumor-related targets were selected by GeneCards database, then to obtain the anti-tumor related targets of CAM. The protein interaction relationship was obtained through STRING database, protein-protein interaction network was constructed using Cytoscape 3.7.2 software, and enrichment analysis of GO and KEGG was conducted. AutoDock Tools 1.5.6 software was used to verify the molecular docking between the key ingredients and the key targets.

Results:
Catechin, epicatechin and luteolin were identified as the key anti-tumor related ingredients, and ESR1, EGFR, MAPK8, MAPK10, AR, PGR, F2 and PIK3CG were identified as the key targets. The GO entries mainly involved metabolic process, cellular process, response to stimulus, organelle, cytosol, etc. The KEGG enrichment showed that the key pathways included pathways in cancer, prostate cancer, pancreatic cancer, breast cancer, estrogen signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, etc. KEGG pathway maps indicated that the anti-tumor effect of CAM may be mainly achieved by intervening related targets in the following pathways: AR-HSP/AR-AR/PSA/proliferation and evading apoptosis; F2/GPCR/…/ROCK/tissue invasion and metastasis; F2/GPCR/…/Raf/MAPK signaling pathway/proliferation and sustained angiogenesis; EGFR/PI3K-Akt signaling pathway/proliferation, evading apoptosis and sustained angiogenesis; EGFR/Grb2/…/Raf/MAPK signaling pathway/proliferation and sustained angiogenesis; ER/Estrogen signaling pathway/proliferation; PR/PR-COR/Wnts-RANKL/proliferation; oxidative stress (.O₂-, .OH, H₂O₂)/KEAP1/NRF2/.../proliferation and evading apoptosis. The results of molecular docking showed that the key active ingredients had a good binding activity with each key target.

Conclusion:
It was predicted that the main active ingredients of CAM could bind to tumor-related targets, such as receptor and coagulation-promoting factor, scavenge free radicals, and then interfere with the occurrence and development of tumors.
Segmentation of Brain MRI Images using Multi-Kernel FCM EHO Method
Authors: Kollem Sreedhar , Prasad Ch. Rajendra , Ajayan J. , S. Sreejith , Joseph LMI Leo , Krishna Patteti 
Published: September 2023

Background:
In image processing, image segmentation is a more challenging task due to different shapes, locations, image intensities, etc. Brain tumors are one of the most common diseases in the world. So, the detection and segmentation of brain tumors are important in the medical field.

Objective:
The primary goal of this work is to use the proposed methodology to segment brain MRI images into tumor and non-tumor segments or pixels.

Methods:
In this work, we first selected the MRI medical images from the BraTS2020 database and transferred them to the contrast enhancement phase. Then, we applied thresholding for contrast enhancement to enhance the visibility of structures like blood arteries, tumors, or abnormalities. After the contrast enhancement process, the images were transformed into the image denoising phase. In this phase, a fourth-order partial differential equation was used for image denoising. After the image denoising process, these images were passed on to the segmentation phase. In this segmentation phase, we used an elephant herding algorithm for centroid optimization and then applied the multi-kernel fuzzy c-means clustering for image segmentation.

Results:
Peak signal-to-noise ratio, mean square error, sensitivity, specificity, and accuracy were used to assess the performance of the proposed methods. According to the findings, the proposed strategy produced better outcomes than the conventional methods.

Conclusion:
Our proposed methodology was reported to be a more effective technique than existing techniques.
Optimal Operation Scheduling of Multi-energy Complementary Systems
Including Offshore Wind Power
Authors: Lu Qiuyu , Yang Yinguo , Zhao Yang , Chen Yue , Xie Pingping 
Published: September 2023

Background:
With the rapid development of offshore wind power in China, offshore wind power is accounting for an increasing proportion of the whole installed power generation in China, which put forward higher requirements for operation scheduling of multi-energy complementary systems including offshore wind power. However, existing studies have paid little attention to the complementary output scheduling of multi-energy systems with a high proportion of offshore wind power, this phenomenon is not conducive to the realization of reasonable operation scheduling.

Objective:
To realize the reasonable operation scheduling of multi-energy systems with a high proportion of offshore wind power.

Methods:
Firstly, the output characteristics of offshore wind power were analyzed and summarized, and modeling was conducted from the perspectives of time distribution, spatial correlation, volatility and randomness, which would serve as the theoretical basis for subsequent researches. Secondly, the complementary rule among offshore wind power and the multi-energy system was analyzed, and the complementary characteristic index was put forward. Then the safety operation was taken as the constraint, and the two-stage operation model of the integrated energy system was established, which considers the auxiliary service costs. In the first stage, the initial generation scheduling was developed according to the day-ahead forecast values of the offshore wind power; in the second stage, the more accurate intra-day operation scheduling was further achieved by considering the intra-day forecast values of offshore wind power and the day-ahead scheduling results. Costs of rotating reserve capacity could be reduced by correcting the deviation of generating capacity, then the revenue-maximizing scheduling strategies were obtained and the output of the pumped-storage power plants was optimized.

Results:
The effectiveness of the model proposed in this paper was verified based on the simulation examples. Compared with the traditional scheduling strategy, the scheduling strategy considering auxiliary service cost proposed in this paper can promote the consumption of offshore wind power, reduce the wind curtailment proportion and improve the electricity sales revenues in the end.

Conclusion:
The research results in this paper provide a reference for the reasonable consumption of multi-energy complementary systems with a high proportion of offshore wind power and improving electricity sales revenues
Evaluating a Novel Infant Heart Rate Detector for Neonatal Resuscitation Efforts: Protocol for a Proof-of-Concept Study
Authors: Abdou Abdelrahman , Krishnan Sridhar , Mistry Niraj 
Published: September 2023

Background
Over 10 million newborns worldwide undergo resuscitation at birth each year. Pediatricians may use electrocardiogram (ECG), pulse oximetry (PO), and stethoscope in determining heart rate (HR), as HR guides the need for and steps of resuscitation. HR must be obtained quickly and accurately. Unfortunately, the current diagnostic modalities are either too slow, obtaining HR in more than a minute, or inaccurate. With time constraints, a reliable robust heart rate detector (HRD) modality is required. This paper discusses a protocol for conducting a methods-based comparison study to determine the HR accuracy of a novel real-time HRD based on 3D-printed dry-electrode single-lead ECG signals for cost-effective and quick HR determination. The HRD’s HR results are compared to either clinical-grade ECG or PO monitors to ensure robustness and accuracy.

Objective
The purpose of this study is to design and examine the feasibility of a proof-of-concept HRD that quickly obtains HR using biocompatible 3D-printed dry electrodes for single-lead neonatal ECG acquisition. This study uses a novel HRD and compares it to the gold-standard 3-lead clinical ECG or PO in a hospital setting.

Methods
A cross-sectional study is planned to be conducted in the neonatal intensive care unit or postpartum unit of a large community teaching hospital in Toronto, Canada, from June 2023 to June 2024. In total, 50 newborns will be recruited for this study. The HRD and an ECG or PO monitor will be video recorded using a digital camera concurrently for 3 minutes for each newborn. Hardware-based signal processing and patent-pending embedded algorithm-based HR estimation techniques are applied directly to the raw collected single-lead ECG and displayed on the HRD in real time during video recordings. These data will be annotated and compared to the ECG or PO readings at the same points in time. Accuracy, F1-score, and other statistical metrics will be produced to determine the HRD’s feasibility in providing reliable HR.

Results
The study is ongoing. The projected end date for data collection is around July 2024.

Conclusions
The study will compare the novel patent-pending 3D-printed dry electrode–based HRD’s real-time HR estimation techniques with the state-of-the-art clinical-grade ECG or PO monitors for HR accuracy and examines how fast the HRD provides reliable HR. The study will further provide recommendations and important improvements that can be made to implement the HRD for clinical applications, especially in neonatal resuscitation efforts. This work can be seen as a stepping stone in the development of robust dry-electrode single-lead ECG devices for HR estimations in the pediatric population.

International Registered Report Identifier (IRRID)
DERR1-10.2196/45512
Validation of a Brief Internet-Based Self-Report Measure of Maladaptive Personality and Interpersonal Schema: Confirmatory Factor Analysis
Authors: Kim Hyeonseong , Jeong Seohyun , Hwang Inae , Sung Kiyoung , Moon Woori , Shin Min-Sup 
Published: September 2023

Background
Existing digital mental health interventions mainly focus on the symptoms of specific mental disorders, but do not focus on Maladaptive Personalities and Interpersonal Schemas (MPISs). As an initial step toward considering personalities and schemas in intervention programs, there is a need for the development of tools for measuring core personality traits and interpersonal schemas known to cause psychological discomfort among potential users of digital mental health interventions. Thus, the MPIS was developed.

Objective
The objectives of this study are to validate the MPIS by comparing 2 models of the MPIS factor structure and to understand the characteristics of the MPIS by assessing its correlations with other measures.

Methods
Data were collected from 234 participants who were using web-based community sites in South Korea, including university students, graduate students, working professionals, and homemakers. All the data were gathered through web-based surveys. Confirmatory factor analysis was used to compare a single-factor model with a 5-factor model. Reliability and correlation analyses with other scales were performed.

Results
The results of confirmatory factor analysis indicated that the 5-factor model (χ2550=1278.1; Tucker-Lewis index=0.80; comparative fit index=0.81; and Root Mean Square Error of Approximation=0.07) was more suitable than the single-factor model (χ2560=2341.5; Tucker-Lewis index=0.52; comparative fit index=0.54; and Root Mean Square Error of Approximation=0.11) for measuring maladaptive personality traits and interpersonal relationship patterns. The internal consistency of each factor of the MPIS was good (Cronbach α=.71-.88), and the correlations with existing measures were statistically significant. The MPIS is a validated 35-item tool for measuring 5 essential personality traits and interpersonal schemas in adults aged 18-39 years.

Conclusions
This study introduced the MPIS, a concise and effective questionnaire capable of measuring maladaptive personality traits and interpersonal relationship schemas. Through analysis, the MPIS was shown to reliably assess these psychological constructs and validate them. Its web-based accessibility and reduced item count make it a valuable tool for mental health assessment. Future applications include its integration into digital mental health care services, allowing easy web-based administration and aiding in the classification of psychological therapy programs based on the obtained results.

Trial Registration
ClinicalTrials.gov NCT05952063; https://www.clinicaltrials.gov/study/NCT05952063
Preferensi Hijauan Pakan Gajah Sumatera (Elephas maximus sumatranus): Studi Kasus di Kawasan Seblat
Authors: Syarifuddin Hutwan 
Published: September 2023

The research has purposed were to know forages of the gajah Sumatera (Elephas maximus sumatranus) preference. Data primer was calculated with direct method in field with vegetation analysis. The result showed that most fodder types were Air Tenang (225). Air Senaba and Air Sabai (215) were similar. Batu Ampar (213), Simpang Tiga (207). Air Riki was lowest (197). The sum of elephant forages were in Air Tenang (70 types), Air Senaba (67 types), Simpang Tiga (66 types), Air Sabai (64 types), Air Riki (63 types) and Batu Ampar (59 types). The forages type was liked as: Colocasia gigantea, Imperata cylindrica, Cynodon dactylon and Ichnanthus vicinus, Angiopteris avecta, Knema sp, Macaranga gigantea, Macaranga pruinosa, Parkia speciosa, Mallotus paniculatus, and Arthocarpus elasticus.
The future of ecological research will not be (fully) automated
Authors: Poisot Timothée , Riva Giulio Dalla , Desjardins-Proulx Philippe , Luccioni Alexandra Sasha 
Published: September 2023

The recent year has seen the creation of large-scale generative
Artificial Intelligence (AI) systems like GPT-4 and LaMDA, which are
generating increasingly plausible outputs ranging from reasonable
answers to questions, images of well-known people or situations, and
convincing conversational exchanges. The most well-known language model,
ChatGPT, is raising concerns across all scientific fields, leading to
calls for its regulation (Hacker 2023). In this viewpoint, we explore
how generative language models interact with the specificities of
ecology’s epistemologies.
VISUAL ANALYSIS PUPPET OF “SI UNYIL” FILM AS INDONESIAN CULTURAL IDENTITY
Authors: Mulyana Agus Rahmat , Dewi Agustina Kusuma , Setiawan Sulistyo 
Published: September 2023

"Si Unyil" is a television series for Indonesian children, created by Suyadi and in production by the National Film Production Center (PPFN). "Si Unyil" belongs to the hand puppets category, consisting of the head, body, and hands. The attraction of the film "Si Unyil" lies in the facial expressions of the doll called Wanda, and is supported by the strength of the story contains elements of humor, joy, tension, to sadness. This study uses a semiotic approach that focuses on the analysis of Wanda "Si Unyil", as the central character in the film "Si Unyil"; and several supporting characters in the film, i.e. Pak Raden, Pak Ogah, Cuplis, and Meilani. Wanda can represent certain facial characters for certain roles in certain storylines. Therefore, Wanda can carry comprehensive meanings that indicate emotional conditions, physical conditions, and environmental conditions. Analysis of "Si Unyil" through the visual of the puppet, concluded that "Si Unyil" contains educational values, morals, and social ethics that are displayed in various daily activities, through dialogue and the behavior between "Si Unyil" and his friends. "Si Unyil" film also possible to be a representation of the Indonesian people, which is guided by the ideology of Pancasila.
Erector spinae plane block versus intercostal nerve block for postoperative analgesia in lung cancer surgery
Authors: Gams Polona , Bitenc Marko , Danojevic Nenad , Jensterle Tomaz , Sadikov Aleksander , Groznik Vida , Sostaric Maja 
Published: September 2023

Abstract

Background
A recent trend in postoperative analgesia for lung cancer surgery relies on regional nerve blocks with decreased opioid administration. Our study aims to critically assess the continuous ultrasound-guided erector spinae plane block (ESPB) at our institution and compare it to a standard regional anesthetic technique, the intercostal nerve block (ICNB).

Patients and methods
A prospective randomized-control study was performed to compare outcomes of patients, scheduled for video-assisted thoracoscopic (VATS) lung cancer resection, allocated to the ESPB or ICNB group. Primary outcomes were total opioid consumption and subjective pain scores at rest and cough each hour in 48 h after surgery. The secondary outcome was respiratory muscle strength, measured by maximal inspiratory and expiratory pressures (MIP/MEP) after 24 h and 48 h.

Results
60 patients met the inclusion criteria, half ESPB. Total opioid consumption in the first 48 h was 21. 64 ± 14.22 mg in the ESPB group and 38.34 ± 29.91 mg in the ICNB group (p = 0.035). The patients in the ESPB group had lower numerical rating scores at rest than in the ICNB group (1.19 ± 0.73 vs. 1.77 ± 1.01, p = 0.039). There were no significant differences in MIP/MEP decrease from baseline after 24 h (MIP p = 0.088, MEP p = 0.182) or 48 h (MIP p = 0.110, MEP p = 0.645), time to chest tube removal or hospital discharge between the two groups.

Conclusions
In the first 48 h after surgery, patients with continuous ESPB required fewer opioids and reported less pain than patients with ICNB. There were no differences regarding respiratory muscle strength, postoperative complications, and time to hospital discharge. In addition, continuous ESPB demanded more surveillance than ICNB.
Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis
Authors: Ljubicic Lidija , Janzic Urska , Unk Mojca , Terglav Ana Sophie , Mohorcic Katja , Seiwerth Fran , Bitar Lela , Badovinac Sonja , Plestina Sanja , Korsic Marta , Kukulj Suzana , Samarzija Miroslav , Jakopovic Marko 
Published: September 2023

Abstract

Background
The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after failing ICI +/− ChT remains an open question, and docetaxel plus nintedanib represent a valid second line option.

Patients and methods
A multicenter retrospective trial of real-life treatment patterns and outcomes of patients with advanced lung adenocarcinoma treated with docetaxel plus nintedanib after the failure of ICI and/or ChT was performed. Patients from 2 Slovenian and 1 Croatian oncological center treated between June 2014 and August 2022 were enrolled. We assessed objective response (ORR), disease control rate (DCR), median progression free survival (PFS), median overall survival (OS), and safety profile of treatment.

Results
There were 96 patients included in the analysis, with ORR of 18.8%, DCR of 57.3%, median PFS of 3.0 months (95% CI: 3.0–5.0 months), and a median OS of 8.0 months (95% CI: 7.0–10.0 months). The majority of patients (n = 47,49%) received docetaxel plus nintedanib as third-line therapy. The ORR for this subset of patients was 19.1%, with a DCR of 57.4%. The highest response rate was observed in patients who received second-line docetaxel plus nintedanib after first-line combination of ChT-ICI therapy (n = 24), with an ORR of 29.2% and DCR of 66.7% and median PFS of 4.0 months (95% CI: 3.0–8.0 months). Fifty-three patients (55.2%) experienced adverse events (AEs), most frequently gastrointestinal; diarrhea (n = 29, 30.2%), and increased liver enzyme levels (n = 17, 17.7%).

Conclusions
The combination of docetaxel and nintedanib can be considered an effective therapy option with an acceptable toxicity profile for patients with advanced NSCLC after the failure of ICI +/− ChT.