bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the impact of organisational model of transvenous lead extraction on the effectiveness and safety of procedure: an observational study
Authors: Tułecki Łukasz , Jacheć Wojciech , Polewczyk Anna , Czajkowski Marek , Targońska Sylwia , Tomków Konrad , Karpeta Kamil , Nowosielecka Dorota , Kutarski Andrzej 
Published: December 2022

ObjectivesTo estimate the impact of the organisational model of transvenous lead extraction (TLE) on effectiveness and safety of procedures.DesignPost hoc analysis of patient data entered prospectively into a computer database.SettingData of all patients undergoing TLE in three centres in Poland between 2006 and 2021 were analysed.Participants3462 patients including: 985 patients undergoing TLE in a hybrid room (HR), with cardiac surgeon (CS) as co-operator, under general anaesthesia (GA), with arterial line (AL) and with transoesophageal echocardiography (TEE) monitoring (group 1), 68 patients—TLE in HR with CS, under GA, without TEE (group 2), 406 patients-TLE in operating theatre (OT) using ‘arm-C’ X-ray machine with CS under GA and with TEE (group 3), 154 patients-TLE in OT with CS under GA, without TEE (group 4), 113 patients-TLE in OT with anaesthesia team, using the ‘arm-C’ X-ray machine, without CS (group 5), 122 patients-TLE in electrophysiology lab (EPL), with CS under intravenous analgesia without TEE and AL (group 6), 1614 patients-TLE in EPL, without CS, under intravenous analgesia without TEE and AL (group 7).Key outcome measureEffectiveness and safety of TLE depending on organisational model.ResultsThe rate of major complications (MC) was higher in OT/HR than in EPL (2.66% vs 1.38%), but all MCs were treated successfully and there was no MC-related death. The use of TEE during TLE increased probability of complete procedural succemss achieving about 1.5 times (OR=1.482; p<0.034) and were connected with reduction of minor complications occurrence (OR=0.751; p=0.046).ConclusionsThe most important condition to avoid death due to MC is close co-operation with cardiac surgery team, which permits for urgent rescue cardiac surgery. Continuous TEE monitoring plays predominant role in immediate decision on rescue sternotomy and improves the effectiveness of procedure.
Identifying classification systems regarding vascular access for haemodialysis: protocol for a scoping review
Authors: Lawrie Katerina , Bafrnec Jan , O’Neill Stephen , Corr Michael , Waldauf Petr , Balaz Peter 
Published: December 2022

IntroductionClassifications are important clinical tools that enable data arrangement, patient categorisation and comparative research. The care of patients with end-stage renal disease who have vascular access requires collaboration of several specialists. In such a field, where several different specialties overlap, strong evidence and well-grounded recommendations for good practice are essential. In this protocol, we aim to search the literature to identify classification systems regarding vascular access for haemodialysis. This protocol serves as a pragmatic tool for setting a systematic approach using scoping review methodology. It also aims to make the study transparent and avoid potential duplication.Methods and analysisWe will follow the Joanna Briggs Institute methodology for the conduct of scoping reviews during the course of the proposed review. Scopus, Web of Science, PubMed, Google Scholar and the ClinicalTrials.gov registry will be searched by two researchers. Titles and abstracts will be screened and articles featuring classifications regarding vascular access for haemodialysis will be eligible for full-text analysis. There will be no age, sex or race limitation for the study populations. The title and abstract (if abstract available) must be in English but there will be no language restrictions for full-text review. Databases will be searched from inception to the date of search. All patients indicated for creation or placement of vascular access will be eligible, as well as patients with already existing vascular access. Classifications regarding preprocedural assessment, vascular access insertion or creation, complications and their management will be included in the study. Classifications regarding peritoneal dialysis will not be eligible. A comprehensive summary of the available evidence will be presented.Ethics and disseminationThe protocol and the review are exempt from ethical approval as there is no direct patient involvement and the review will summarise data from already published literature. The final article will be submitted to a peer-reviewed scientific journal.
Scoping review protocol on the health of sub-Saharan African migrants in the Asia-Pacific region
Authors: Yang Fan , Han Xinkun , Song Yumeng , Tang Weiming , Wu Dan , Wang Cheng , Bodomo Adams B. , Guo Yan , Tucker Joseph D. 
Published: December 2022

IntroductionIncreasing economic opportunities have attracted people from sub-Saharan Africa to migrate to the Asia-Pacific region in the last two decades. The information on the health situation of these migrants is limited. We aim to assess scientific evidence on the health of sub-Saharan African migrants in the Asia-Pacific region using a scoping review.Methods and analysisThe review will be conducted according to the JBI guide on evidence synthesis, and the final results will be organised and reported in line with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for scoping reviews. Search strategies have been developed centred on population-concept-context elements including sub-Saharan Africa, Asia-Pacific, migration and health. A total of eight databases will be searched, including PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, ProQuest, Scopus, Web of Science,Wanfangand CNKI. Title and abstract screening and full-text screening will be conducted by two researchers independently. Data will be charted according to predesigned form.Ethics and disseminationThis study involves neither human participants nor unpublished secondary data. Institutional review board approval is therefore not required. Findings of this scoping review will be disseminated through publication in a peer-reviewed journal, through academic network and project report.
Association of socioeconomic position and childhood obesity in Finland: a registry-based study
Authors: Paalanen Laura , Levälahti Esko , Mäki Päivi , Tolonen Hanna , Sassi Franco , Ezzati Majid , Laatikainen Tiina 
Published: December 2022

ObjectiveTo identify what dimensions of socioeconomic position (SEP) are most closely associated with childhood obesity in Finland, leveraging population-wide data among the whole child population aged 2–17 years in Finland.DesignRegistry-based study.SettingData from several administrative registries linked on individual level covering the whole of Finland were used. Data on height and weight measurements in 2018 were obtained from the Register of Primary Health Care visits and data on sociodemographic and socioeconomic indicators (2014–2018) from Statistics Finland.ParticipantsChildren aged 2–17 years with valid height and weight measurements performed at the child health clinic or school healthcare in 2018 (final n=194 423).Main outcome measuresObesity was defined according to WHO Growth Reference curves. Sociodemographic and socioeconomic indicators were linked on individual level for adults (both parents) who lived in the same household (42 predictors). Boosted regression model was used to analyse the contribution of SEP to obesity.ResultsFrom socioeconomic indicators, annual household income (12.6%) and mother and father’s educational level (12.6% and 8.1%, respectively) had the highest relative influence on obesity risk. The relative influence of a child’s sex was 7.7%.ConclusionsThe parents’ SEP was inversely associated with obesity among the offspring. A remarkable number of objective SEP indicators were analysed with parents’ education and household income finally being the indicators most strongly associated with obesity among children. In future research, more attention should be paid to reliable and objective ways of measuring educational status and income rather than on developing new SEP indicators. Administrative registries with information on both healthcare and socioeconomic indicators can in future provide better opportunities to assess the influence of SEP on various health risks.
Integrating pre-exposure prophylaxis of HIV infection into family planning services: a scoping review
Authors: Gotsche Caroline I , Steyn Petrus S , Narasimhan Manjulaa , Rodolph Michelle , Baggaley Rachel , Kiarie James N 
Published: December 2022

IntroductionThe aim of this review was to map evidence of integrating pre-exposure prophylaxis (PrEP) for HIV prevention into family planning services. A comprehensive package, using a combination of PrEP and contraceptive delivery, could reduce the number of new HIV infections and/or unintended pregnancies for at-risk women and adolescent girls.MethodsA scoping literature search was conducted between August 2020 and October 2020. After developing the review question, electronic databases (MEDLINE, Embase, Cochrane Library, Global Health, Web of Science) were systematically reviewed. All types of articles published from 2012 to August 2020 in English were included. The intended outcome was to identify barriers and enablers of integrating services at the client-level and provider-level.Results38 articles met inclusion criteria, with 16 from low-and middle-income countries and 22 from high-income countries. Barriers at the client-level included a lack of risk perception associated with low uptake and continuation of PrEP and pill burden; and at the provider-level, barriers included a lack of studies on cost-effectiveness of integrating services and provider training and knowledge. Facilitators included the initiation of PrEP and contraception at the same time and by the same provider or HIV self-testing.ConclusionMapping and synthesising current evidence, this review identified key barriers and facilitators for the integration of PrEP into family planning services for women and adolescent girls. In order to address these factors, more implementation research in a variety of settings is needed to meet women’s sexual and reproductive health needs globally.
Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjögren’s syndrome and systemic sclerosis
Authors: Andraos Rama , Ahmad Awais , Eriksson Per , Dahlström Örjan , Wirestam Lina , Dahle Charlotte , Hesselstrand Roger , Bengtsson Anders A , Jönsen Andreas , Andréasson Kristofer , Sjöwall Christopher 
Published: December 2022

ObjectiveSLE, primary Sjögren’s syndrome (pSS) and systemic sclerosis (SSc) are heterogeneous autoimmune diseases with a dysregulated type I interferon (IFN) system. The diseases often show overlapping clinical manifestations, which may result in diagnostic challenges. We asked to which extent SSc-associated autoantibodies are present in SLE and pSS, and whether these link to serum IFN-α, clinical phenotypes and sex. Samples with clinical data from patients with SSc and healthy blood donors (HBDs) served as controls. Finally, the diagnostic performance of SSc-associated autoantibodies was evaluated.MethodsSamples from well-characterised subjects with SLE (n=510), pSS (n=116), SSc (n=57) and HBDs (n=236) were analysed using a commercially available immunoassay (EuroLine Systemic Sclerosis Profile (IgG)). IFN-α was quantified by ELISA. Self-reported data on Raynaud’s phenomenon (RP) were available.ResultsWith exceptions for anti-Ro52/SSA and anti-Th/To, SSc-associated autoantibodies were more frequent in SSc than in SLE, pSS and HBDs regardless of sex. IFN-α levels correlated with the number of positive SSc-associated autoantibodies (r=0.29, p<0.0001) and associated with Ro52/SSA positivity (p<0.0001). By using data from SLE, SSc and HBDs, RP was significantly associated with topoisomerase I, centromere protein (CENP)-B, RNA polymerase III 11 kDa, RNA polymerase III 155 kDa and PM-Scl100 whereas Ro52/SSA associated inversely with RP. In SLE, CENP-A was associated with immunological disorder, CENP-B with serositis and Ku with lupus nephritis. By combining analysis of ANA (immunofluorescence) with SSc-associated autoantibodies, the diagnostic sensitivity reached 98% and the specificity 33%.ConclusionsThe 13 specificities included in the EuroLine immunoassay are commonly detected in SSc, but they are also frequent among individuals with other diseases imprinted by type I IFNs. These findings are valuable when interpreting serological data on patients with suspected SSc, especially as patients may present with disease manifestations overlapping different rheumatological diseases. In SLE, we observed associations between manifestations and SSc-associated autoantibodies which have not previously been reported.
Glucocorticoid tapering and associated outcome in patients with newly diagnosed systemic lupus erythematosus: the real-world GULP prospective observational study
Authors: Floris Alberto , Chessa Elisabetta , Sebastiani Gian Domenico , Prevete Immacolata , Iannone Florenzo , Coladonato Laura , Govoni Marcello , Bortoluzzi Alessandra , Mosca Marta , Tani Chiara , Doria Andrea , Iaccarino Luca , Franceschini Franco , Fredi Micaela , Conti Fabrizio , Spinelli Francesca Romana , Bellisai Francesca , D'Alessandro Roberto , Zanetti Anna , Carrara Greta , Scirè Carlo Alberto , Cauli Alberto , Piga Matteo 
Published: December 2022

ObjectiveA subanalysis of the multicentre Early Lupus inception cohort was performed to investigate the real-world Glucocorticoids (GCs) Use in newly diagnosed systemic lupus erythematosus (SLE) Patients (GULP).MethodsPatients starting prednisone (PDN) ≥5 mg/day and concomitant hydroxychloroquine or immunosuppressant within 12 months of SLE classification were enrolled. Core set variables were recorded at baseline and every 6 months, including changes in PDN dose, European Consensus Lupus Activity Measurement (ECLAM) and Systemic Lupus International Collaborating Clinics damage index. Regression models analysed predictors of tapering PDN<5 mg/day at any time and outcomes associated with different patterns of GCs tapering.ResultsThe GULP study included 127 patients with SLE; 73 (57.5%) tapered and maintained PDN <5 mg/day, and 17 (13.4%) discontinued PDN within a 2-year follow-up. Renal involvement (HR: 0.41; p=0.009) and lower C3 serum levels (HR: 1.04; p=0.025) predicted a lack of PDN tapering below 5 mg/day. High ECLAM scores were associated with a greater probability of increasing PDN dose (OR: 1.6; p=0.004), independently of daily intake. Disease relapse rate did not statistically differ (p=0.706) between patients tapering PDN <5 mg/day (42/99, 42.4%) and those tapering PDN without dropping below 5 mg/day (13/28, 46.4%). Every month on PDN <5 mg/day associated with lower damage accrual (IRR: 0.96; p=0.007), whereas never tapering PDN <5 mg/day associated with a higher risk of developing GC-related damage (OR 5.9; p=0.014).ConclusionTapering PDN <5 mg/day was achieved and maintained in half of newly diagnosed patients with SLE and may represent a good balance between the need to prevent damage accrual and the risk of disease relapse.
Antioxidative Effect of Amomum testaceum Ridl. Extract for Protecting against Vascular Dementia
Authors: Kaewkaen Pratchaya 
Published: December 2022

Vascular dementia is caused by decreased blood flow to the brain, which leads to neuronal damage and subsequent death. Therefore, development of alternative neuroprotective agents is critical. This study is aimed at investigating the effects of Amomum testaceum Ridl. extract or Siam cardamom extract (SCE) on oxidative markers in a rat model of vascular dementia. The phenolic content of SCE, represented as gallic acid equivalent (mg/100 GAE), was discovered to be

128.56
±
0.58

mg/100 GAE. The EC50 values for the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities of SCE were

32.48
±
0.39

ug/mL. In addition, the reducing power of SCE, via a ferric reducing antioxidant power assay, was also determined, with an EC50 value of

142.55
±
0.56

ug/mL. SCE was administered orally to adult male Wistar rats weighing 250–300 g at doses of 100, 300, and 500 mg/kg over the course of 14 days; then, the rats underwent surgery of the right middle cerebral artery, producing an occlusion imitating vascular dementia in a controlled environment. All rats were euthanized to obtain brain tissue for biochemical testing and analysis. The results showed that malondialdehyde decreased and superoxide dismutase, catalase, and glutathione peroxidase increased at all doses (100, 300, and 500 mg/kg) of SCE (

P
<
0.05

). In addition, SCE was shown to lower the expression level of S100B, a marker of neurologic injury (

P
<
0.05

). The free radical scavenging and anti-inflammatory capabilities of SCE suggest that it has the potential to be used as a food supplement to protect against oxidative damage in vascular dementia. However, further clinical investigations are essential to elucidate this in clinical trials.
O Ateneu, de Raul Pompéia, e o programa das escolas cívico-militares do governo Bolsonaro: espaço-tempo claustrotópico
Authors: Cruz Ana Carolina De Picoli De Souza , Cortina Arnaldo 
Published: December 2022

Este artigo tem como objetivo contribuir com as inúmeras reflexões acerca dos rumos da educação brasileira. Fundamentados na teoria da semiótica discursiva, por meio da análise do tempo, do espaço e da ideologia na enunciação e no enunciado, apresentamos uma comparação entre o romance O Ateneu, de Raul Pompéia (1888), e as diretrizes das escolas cívico-militares (2019) do governo Bolsonaro. Acreditando que não só os espaços fechados encarceram, mas também (e principalmente) os discursos têm o poder de confinar, buscamos, ainda, analisar como as ideologias do presente revelam vestígios do passado e nos levam a questionar se estamos (re)existindo ou resistindo.
Práticas e estratégias de cancelamento virtual
Authors: Moreira Patricia Veronica , Santos Flavia Karla Ribeiro , Portela Jean Cristtus 
Published: December 2022

Considerando as reflexões sobre os níveis de pertinência da análise semiótica e as diferentes cenas predicativas observadas nas redes sociais – que utilizam a violência em diferentes intensidades para destruir a imagem pública do outro, ou, em certos casos, mantê-la –, buscamos, neste trabalho, identificar como se configuram as práticas e estratégias relacionadas à cultura do cancelamento. Essas práticas, e as estratégias que as acomodam, são realizadas no ambiente virtual, na forma de comentários em redes sociais e outros tipos de mídia on-line que, simulando um tribunal virtual e assumindo os papéis actanciais de juízes, jurados e executores, sancionam negativamente o sujeito que enuncia discursos desinformados, preconceituosos e intolerantes ou exprime comportamentos que podem corroborar discursos negacionistas, e aplicam punições diversas. Por outro lado, as mesmas práticas podem desencadear um processo de reiteração e forte assunção do discurso ou comportamento que levou o sujeito a ser inicialmente julgado e cancelado. Esse comportamento é observado em grupos que manifestam discursos de apoio a valores morais historicamente enraizados na estrutura social e que não condizem com uma sociedade que visa a ser mais pacífica, inclusiva, sustentável e justa.
Maternal Inheritance of Familial Hypercholesterolemia Gene Mutation Predisposes to Coronary Atherosclerosis as Assessed by Calcium Score in Adulthood
Authors: Mourre Florian , Giorgi Roch , Gallo Antonio , Boccara Franck , Bruckert Eric , Carrié Alain , Hankard Regis , Inamo Jocelyn , Laboureau Sandrine , Moulin Philippe , Valéro René , Béliard Sophie , Angoulvant Denis , Beliard Sophie , Boccara Franck , Bruckert Eric , Cariou Bertrand , Carreau Valérie , Carrie Alain , Charrieres Sybil , Cottin Yves , Di Filippo Mathilde , Ducluzeau Pierre Henri , Dulong Sonia , Durlach Vincent , Farnier Michel , Ferrari Emile , Ferrieres Dorota , Ferrieres Jean , Gallo Antonio , Hankard Regis , Inamo Jocelyn , Kalmykova Olga , Krempf Michel , Lemale Julie , Moulin Philippe , Paillard François , Peretti Noel , Perrin Agnes , Pradignac Alain , Rabes Jean Pierre , Rigalleau Vincent , Schiele François , Sultan Ariane , Tounian Patrick , Valero René , Verges Bruno , Yelnik Cecile , Ziegler Olivier 
Published: December 2022

Background:
Animal studies have demonstrated that fetal exposure to high maternal cholesterol levels during pregnancy predisposes to aortic atheroma in the offspring. In humans, little is known about the consequences of this exposure on the development of atherosclerotic cardiovascular disease later in life. We wanted to assess whether maternal/paternal inheritance of familial hypercholesterolemia (FH) gene mutation could be associated with subclinical coronary atherosclerosis.

Methods:
We retrospectively included 1350 patients, followed in the French registry of FH, with a documented genetic diagnosis. We selected 556 age- and sex-matched pair of patients based on the sex of the parents who transmitted the FH gene mutation, free of coronary cardiovascular event, and with a subclinical coronary atherosclerosis evaluation assessed using coronary artery calcium (CAC) score. We performed univariate and multivariate analysis to assess the individual effect of parental inheritance of the FH gene mutation on the CAC score.

Results:

In the whole population, patients with maternal inheritance of FH gene mutation (n=639) less frequently had a family history of premature cardiovascular events (27.7% versus 45%,
P
<0.0001) and were 2 years older (46.9±16.8 versus 44.7±15.9 years old,
P
=0.02) than those with paternal inheritance (n=711). There was no difference in the prevalence of cardiovascular events between the two groups. In the matched subgroup, maternal inheritance was significantly associated with an increase in CAC score value by 86% (95% CI, 23%–170%;
P
=0.003), a 1.81-fold risk of having a CAC score ≥100 Agatston units (95% CI, 1.06–3.11;
P
=0.03), and a 2.72-fold risk of having a CAC score ≥400 Agatston units (95% CI, 1.39–5.51;
P
=0.004) when compared with paternal inheritance in multivariate analysis.

Conclusions:
Maternal inheritance of FH gene mutation was associated with more severe subclinical coronary atherosclerosis assessed by CAC score and may be considered as a potential cardiovascular risk factor.