bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of Kardar-Parisi-Zhang scaling on a digital quantum simulator
Authors: Keenan Nathan , Robertson Niall F. , Murphy Tara , Zhuk Sergiy , Goold John 
Published: July 2023

AbstractUnderstanding how hydrodynamic behaviour emerges from the unitary evolution of the many-particle Schrödinger equation is a central goal of non-equilibrium statistical mechanics. In this work we implement a digital simulation of the discrete time quantum dynamics of a spin-$$\frac{1}{2}$$

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XXZ spin chain on a noisy near-term quantum device, and we extract the high temperature transport exponent at the isotropic point. We simulate the temporal decay of the relevant spin correlation function at high temperature using a pseudo-random state generated by a random circuit that is specifically tailored to the ibmq-montreal 27 qubit device. The resulting output is a spin excitation on a homogeneous background on a 21 qubit chain on the device. From the subsequent discrete time dynamics on the device we are able to extract an anomalous super-diffusive exponent consistent with the conjectured Kardar-Parisi-Zhang (KPZ) scaling at the isotropic point. Furthermore we simulate the restoration of spin diffusion with the application of an integrability breaking potential.
The daily updated Dutch national database on COVID-19 epidemiology, vaccination and sewage surveillance
Authors: Geubbels E. L. P. E. , Backer J. A. , Bakhshi-Raiez F. , van der Beek R. F. H. J. , van Benthem B. H. B. , van den Boogaard J. , Broekman E. H. , Dongelmans D. A. , Eggink D. , van Gaalen R. D. , van Gageldonk A. , Hahné S. , Hajji K. , Hofhuis A. , van Hoek A. J. , Kooijman M. N. , Kroneman A. , Lodder W. , van Rooijen M. , Roorda W. , Smorenburg N. , Zwagemaker F. ,   National sewage surveillance group, Beck Yu-Ling , van Beugen Dorothe , van Boven Michiel , Breuning Titus , van Buuren Chesley , Dijkstra Sipke , Ding Weiyi , van der Drift Anne-Merel , Grift Ivo , Haver Auke , Hetebrij Wouter , van de Hoef Demi , de Jong Kim , de Klijne Arnoud , Koelewijn Jaap , Kooij Jannetje , Korevaar Jeroen , Lynch Gretta , Nagelkerke Erwin , Nicanci Süeda , Peters Noel , Peterse Céline , van der Plaats Rozemarijn , Poorter Elsa , Raaijmakers Gino , van Rijckevorsel Lars , de Rijk Sharona , Sam-Sin Nathanaël , Senyer Merve , Sheikh Moghaddas Reza , Stouten Sjors , Theijn Rick , van Velzen Max , Voshart Ilse , Welling Anne , Wijsmuller Arno , Winkelhorst Nicolas , Wong-Loi-Sing Gimairo ,   RIVM COVID-19 epidemiology, surveillance team, Andeweg Stijn , van den Berg Patrick , Berry Danytza , Boudewijns Bronke , de Bruijn Siméon , Bulsink Kirsten , Dalhuisen Thomas , van Iersel Senna , Jenniskens Liz , Jongenotter Femke , de Lange Marit , Lanooij Susan , de Melker Hester , Maxwell Amber , Neppelenbroek Nienke , Nijman Steven , de Oliviera Bressane Lima Priscila , Petit Fleur , Smit Tara , Teirlinck Anne , Valk Anne-Wil , Veldhuijzen Irene , Verstraten Carolien , Wielders Lieke , Willekens Guido , de Keizer N. F. , van Walle I. , de Roda Husman A. M. , Ruijs C. , van den Hof S. 
Published: July 2023

AbstractThe Dutch national open database on COVID-19 has been incrementally expanded since its start on 30 April 2020 and now includes datasets on symptoms, tests performed, individual-level positive cases and deaths, cases and deaths among vulnerable populations, settings of transmission, hospital and ICU admissions, SARS-CoV-2 variants, viral loads in sewage, vaccinations and the effective reproduction number. This data is collected by municipal health services, laboratories, hospitals, sewage treatment plants, vaccination providers and citizens and is cleaned, analysed and published, mostly daily, by the National Institute for Public Health and the Environment (RIVM) in the Netherlands, using automated scripts. Because these datasets cover the key aspects of the pandemic and are available at detailed geographical level, they are essential to gain a thorough understanding of the past and current COVID-19 epidemiology in the Netherlands. Future purposes of these datasets include country-level comparative analysis on the effect of non-pharmaceutical interventions against COVID-19 in different contexts, such as different cultural values or levels of socio-economic disparity, and studies on COVID-19 and weather factors.
The Translational Data Catalog - discoverable biomedical datasets
Authors: Welter Danielle , Rocca-Serra Philippe , Grouès Valentin , Sallam Nirmeen , Ancien François , Shabani Abetare , Asariardakani Saeideh , Alper Pinar , Ghosh Soumyabrata , Burdett Tony , Sansone Susanna-Assunta , Gu Wei , Satagopam Venkata 
Published: July 2023

AbstractThe discoverability of datasets resulting from the diverse range of translational and biomedical projects remains sporadic. It is especially difficult for datasets emerging from pre-competitive projects, often due to the legal constraints of data-sharing agreements, and the different priorities of the private and public sectors. The Translational Data Catalog is a single discovery point for the projects and datasets produced by a number of major research programmes funded by the European Commission. Funded by and rooted in a number of these European private-public partnership projects, the Data Catalog is built on FAIR-enabling community standards, and its mission is to ensure that datasets are findable and accessible by machines. Here we present its creation, content, value and adoption, as well as the next steps for sustainability within the ELIXIR ecosystem.
An open presurgery MRI dataset of people with epilepsy and focal cortical dysplasia type II
Authors: Schuch Fabiane , Walger Lennart , Schmitz Matthias , David Bastian , Bauer Tobias , Harms Antonia , Fischbach Laura , Schulte Freya , Schidlowski Martin , Reiter Johannes , Bitzer Felix , von Wrede Randi , Rácz Atilla , Baumgartner Tobias , Borger Valeri , Schneider Matthias , Flender Achim , Becker Albert , Vatter Hartmut , Weber Bernd , Specht-Riemenschneider Louisa , Radbruch Alexander , Surges Rainer , Rüber Theodor 
Published: July 2023

AbstractAutomated detection of lesions using artificial intelligence creates new standards in medical imaging. For people with epilepsy, automated detection of focal cortical dysplasias (FCDs) is widely used because subtle FCDs often escape conventional neuroradiological diagnosis. Accurate recognition of FCDs, however, is of outstanding importance for affected people, as surgical resection of the dysplastic cortex is associated with a high chance of postsurgical seizure freedom. Here, we make publicly available a dataset of 85 people affected by epilepsy due to FCD type II and 85 healthy control persons. We publish 3D-T1 and 3D-FLAIR, manually labeled regions of interest, and carefully selected clinical features. The open presurgery MRI dataset may be used to validate existing automated algorithms of FCD detection as well as to create new approaches. Most importantly, it will enable comparability of already existing approaches and support a more widespread use of automated lesion detection tools.
Characteristic impairment of progesterone response in cultured cervical fibroblasts obtained from patients with refractory cervical insufficiency
Authors: Sugita Yosuke , Kuwabara Yoshimitsu , Katayama Akira , Matsuda Shigeru , Manabe Ichiro , Suzuki Shunji , Oishi Yumiko 
Published: July 2023

AbstractPreterm birth (PTB) is the leading cause of neonatal mortality, and reducing the PTB rate is one of the most critical issues in perinatal medicine. Cervical insufficiency (CI), a major cause of PTB, is characterised by premature cervical ripening in the second trimester, followed by recurrent pregnancy loss. Although multiple clinical trials have suggested that progesterone inhibits cervical ripening, no studies have focused on progesterone-induced molecular signalling in CI. Here, we established a primary culture system for human uterine cervical fibroblasts using a sample of patients with refractory innate CI who underwent transabdominal cervical cerclage and patients with low Bishop scores who underwent elective caesarean section as controls. RNA sequencing showed that the progesterone response observed in the control group was impaired in the CI group. This was consistent with the finding that progesterone receptor expression was markedly downregulated in CI. Furthermore, the inhibitory effect of progesterone on lipopolysaccharide-induced inflammatory stimuli was also impaired in CI. These results suggest that abnormal cervical ripening in CI is caused by the downregulation of progesterone signalling at the receptor level, and provide a novel insight into the molecular mechanism of PTB.
Selected bacteria in sheep stool depending on breed and physiology state
Authors: Cholewińska Paulina , Szeligowska Natalia , Wojnarowski Konrad , Nazar Paulina , Greguła-Kania Monika , Junkuszew Andrzej , Rant Witold , Radzik-Rant Aurelia , Marcinkowska Anna , Bodkowski Robert 
Published: July 2023

AbstractOne of the important factors influencing the microbial community of ruminants, besides environment or diet, are breed and physiology. Therefore, the purpose of this study was to assess these changes in the levels of basic microbial phyla and families. For this study, qPCR analysis was performed to determine the level of bacteria (Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria clusters and Clostridiaceae, Lactobacillaceae families) in the feces of ewes of three native Polish sheep breeds (Polish Lowland Sheep (PON), Świniarka Sheep (SW), and synthetic line BCP) at different physiological periods (conception, early pregnancy, lambing, end of lactation). The animals were kept in the same environment and were at the same age (2-years). The results showed a significant effect of both breed (p = 0.038) and physiological period (p < 0.05, p < 0.01) on the levels of bacteria analyzed. The breed showed differences across physiological periods. The influence of the race factor was noted primarily between the BCP synthetic line and the other two breeds (differences in terms of all analyzed clusters and families except Actinobacteria phyla). In the case of SW and PON, however, the observed differences were only at the level of Proteobacteria cluster and Clostridiaceae family. On the other hand, the early pregnant and lambing periods were the most microbiologically diverse in terms of the analyzed clusters and families of bacteria.
Co-construction et évaluation d’ateliers de soutien pour les parents-aidants en pédiatrie : une recherche-action participative
Authors: Dubois Anne-Catherine , Aujoulat Isabelle , Boland Maëlle , Lahaye Magali 
Published: July 2023

Introduction : Lorsqu’un enfant présente un problème de santé chronique complexe, ses parents endossent un rôle de proche aidant. La double identité de parent et de proche aidant les expose au risque d’épuisement. Objectifs : Pour les accompagner dans la prise de conscience de leurs besoins et dans l’identification et la mobilisation de leurs ressources, nous avons développé et évalué des ateliers de soutien pour parents-aidants. Méthodes : Nous avons mené une recherche-action participative, itérative et évaluative, soutenue par un comité de pilotage (professionnels, parents et chercheurs). Trois groupes de parents (N = 18) ont participé à 4 ateliers de soutien. Les données collectées ont été traitées par une analyse thématique. Résultats : Le dispositif des ateliers a permis aux parents de bénéficier de temps pour eux, de prendre conscience de ce qu’ils vivaient, d’échanger entre parents, et d’envisager des changements dans leur quotidien. Ces bénéfices ont été soutenus par un dispositif en ligne, encadré par des professionnels de la santé physique et psychologique, proposant des ateliers de soutien aux parents quelles que soient les caractéristiques de leur famille et de leur enfant. Discussion et conclusion : Ces ateliers constituent des temps de rencontre qui visent à préserver l’équilibre personnel et familial et qui pourraient participer à la prévention de l’épuisement parental.
Investigation on effects of cobalt-chromite nanoparticle blends in compression-ignition engine
Authors: Baluchamy Anbarasan , Karuppusamy Muralidharan , C Sakthi Rajan , Senthamaraikannan Balamurugan 
Published: July 2023

Abstract
This work provides a high-level overview of the performance parameters of a nanoparticle-fuelled engine emulsion. The nanoparticle of cobalt chromite was created by a straightforward laboratory procedure. The nanoparticles were introduced at concentrations of 20 ppm, 40 ppm, 60 ppm, and 80 ppm, with the optimal concentration being found to be a Kapok methylester-20 (KME20) blend. Varying the timings and operated the engine at a constant speed 1800 rpm. Injections can be given at 19, 23, or 27 degrees before the before top dead centre, which are referred to as retardation, standard, and advanced, respectively. The Brake thermal efficiency is increased by 7.2% when the blend of KME20 with 80 ppm advanced is compared to the triggered ignition delay. Unburnt hydrocarbon and carbon monoxide levels in the 80 ppm-Advanced KME20 mix are reduced by 37.86% and 41.66%, respectively, when compared to the standard injection period. Oxides of nitrogen and carbon monoxide in the blend KME20 with 20 ppm - retardation rose by 16.45 and 9.5 percent, respectively, compared to the duration of normal injections. Increased the brake thermal efficiency for KME20 with nanoparticles at concentration of 80 ppm is 7.5% as related to same blend without doping of nanoparticles. Using kapok methyl ester with nanoparticles doped in the standard engine can improve efficiency and performance.
Genome assemblies of Vigna reflexo-pilosa (créole bean) and its progenitors, Vigna hirtella and Vigna trinervia, revealed homoeolog expression bias and expression-level dominance in the allotetraploid
Authors: Pootakham Wirulda , Sonthirod Chutima , Naktang Chaiwat , Yundaeng Chutintorn , Yoocha Thippawan , Kongkachana Wasitthee , Sangsrakru Duangjai , Somta Prakit , Tangphatsornruang Sithichoke 
Published: July 2023

Abstract
Vigna reflexo-pilosa (créole bean) is a wild legume belonging to the subgenus Ceratoropis and is widely distributed in Asia. Créole bean is the only tetraploid species in the genus Vigna, and it has been shown to derive from the hybridization of Vigna hirtella and Vigna trinervia. In this study, we combined the long-read PacBio technology with the chromatin contact mapping (Hi-C) technique to obtain a chromosome-level assembly of V. reflexo-pilosa. The final assembly contained 998,724,903 bases with an N50 length of 42,545,650 bases. Our gene prediction recovered 99.4% of the highly conserved orthologs based on the BUSCO analysis. To investigate homoeolog expression bias and expression level dominance in the tetraploid, we also sequenced and assembled the genomes of its progenitors. Overall, the majority of the homoeolog pairs (72.9%) displayed no expression bias, and among those that exhibited biased expression, 16.3% showed unbalanced homoeolog expression bias toward the V. trinervia subgenome. Moreover, 41.2% and 36.2% of the expressed gene pairs exhibited transgressive expression and expression level dominance, respectively. Interestingly, the genome-wide expression level dominance in the tetraploid was biased toward the V. trinervia subgenome. The analysis of methylation patterns also revealed that the average methylation levels in coding regions were higher in the V. hirtella subgenome than those in the V. trinervia subgenome. The genomic/transcriptomic resources for these three species are useful not only for the development of elite cultivars in Vigna breeding programs but also to researchers studying comparative genomics and investigating genomic/epigenomic changes following polyploid events.
Differential Effects of Antimalarial Drugs on Parasite Clearance Rates Are Reflected by Plasmodium falciparum Ring Ratio
Authors: Saidi Alexuse M , Zhang Bo , Jiang Melody , Kawaza Kondwani , Musaya Janelisa , Taylor Terrie , Seydel Karl 
Published: July 2023

Abstract

Background
The location of Plasmodium falciparum within the body is determined by the life cycle of the parasite; young rings are in the peripheral blood, whereas mature parasites are sequestered in deep tissues. We can calculate a “ring ratio,” the proportion of parasites in the periphery to the total number of parasites in the body. Artesunate acts on all parasite life stages, whereas quinine is effective only on sequestered parasites. Children with cerebral malaria (CM) treated with artesunate clear parasites faster than those treated with quinine. In this study, we established the relationship between ring ratio and parasite clearance rate and used the ring ratio to determine if the benefit derived from artesunate treatment could be attributed to its broader effect on life cycle stages.

Methods
Ring ratios were calculated for 400 hospitalized children with CM in Blantyre, Malawi between 2010 and 2019 (quinine: 2010–2013, artesunate: 2014–2019).

Results
In both treatment groups, parasite clearance rates were positively associated with the ring ratios, with a stronger association in the artesunate era than the quinine era. In the quinine era, an increase of 1-unit log10 difference between parasitemia and plasma P falciparum histidine-rich protein 2 (a proxy for ring ratio) resulted in a 0.27-unit increase in the parasite clearance rate, whereas in the artesunate era an equal increase resulted in a 0.41-unit increase (P = .04 for the difference).

Conclusions
This analysis provides in vivo evidence supporting the hypothesis that more rapid parasite clearance rates in artesunate recipients are due to its superiority over quinine in killing ring-stage parasites.
A case of eosinophilic granulomatous polyangiitis with concurrent central and peripheral nervous system involvement
Authors: Challa Anusha , Sirisha Sai , Khandelia Harsh , Parekh Mihir , Patil Anuja , Jayalakshmi Sita 
Published: July 2023

Abstract
Eosinophilic granulomatous polyangiitis (EGPA) like other antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has multisystemic involvement. It commonly manifests with prodromal pulmonary involvement as asthma, chronic sinusitis followed by systemic vasculitic complications associated with blood and tissue eosinophilia. Central nervous system manifestations at presentation are uncommon compared with peripheral nervous system involvement. Vasculitic neuropathy in EGPA commonly presents as mononeuritis multiplex but rarely as polyradiculopathy. Late onset EGPA often presents with systemic involvement, and early diagnosis is a key to prevent further complications. The neuropathy in late onset EGPA is often refractory to immunosuppression and corticosteroids treatment. We report a case of EGPA with late onset asthma presenting with acute infarct and demyelinating polyradiculoneuropathy that progressed with bulbar paralysis and profound dysautonomia. This illustrates simultaneous involvement of central and peripheral nervous system with EGPA. Autonomic dysfunction can occur in patients of EGPA with multisystem involvement, which may predict severe complications.
A case report of abscopal toxicity in a patient with lung adenocarcinoma
Authors: Reddy Aswanth , Nwankwo Nkolika , Sekar Arjun , Kumar Aswini 
Published: July 2023

Abstract
The abscopal effect describes tumor responses outside the irradiated field. The literature shows increased overall survival and response rates in patients receiving immunotherapy and radiation, likely from exaggerated abscopal effects. We present a 57-year-old woman with stage 4 lung adenocarcinoma who received treatment with a combination of chemotherapy and immunotherapy. She had disease progression on maintenance immunotherapy, confirming resistance. Palliative radiation to the sternal bone lesion resulted in a significant response to all areas of cancer, confirming the abscopal effect. Unfortunately, she developed severe pneumonitis; to our knowledge, this is the first case of abscopal lung toxicity.
Isaiah, the Twelve, and the Prophetic Anthology
Authors: Mastnjak Nathan 
Published: July 2023

Abstract
In the Hellenistic period, scribes gathered the prophetic collections and edited, arranged, and copied them onto longer book-scrolls. These transformation in the media of prophecy involved significant transformations of the literature. Chapter 5 analyses Isaiah and the book of the Twelve as explicit anthologies of prophetic literature. The identification of Isaiah as an anthology suggests that when Second and Third Isaiah were added to First Isaiah, they were originally intended to be read not as pseudonymously attributed to Isaiah of Jerusalem, but as anonymous prophetic works thematically related to each other and to the First Isaiah. Marginal notations in 1QIsaa, the oldest nearly complete manuscript of Isaiah, possibly corroborate this reading by identifying multiple prophetic voices in the text.
Conclusion
Authors: Mastnjak Nathan 
Published: July 2023

Abstract
This chapter gathers together the various strands of the argument and points toward the broader implications this study has beyond the biblical prophetic corpus. Left unexamined, concepts of textuality arising in print cultures influence the way modern biblical scholars tend to think about biblical books. The study suggests that ancient Israelite literature in general should be thought of as collections of textual objects rather than single scrolls. This new way of thinking about the materiality of biblical compositions opens up new possible solutions for classic problems in the field. It also directs attention to the important role played by the Hellenistic bookmakers who were responsible for transforming these libraries into single-volume scroll-books.
A Life Course Approach to Diabetes
Authors: Papadimos Emily , Morton Jedidiah , Harding Jessica , Barr Elizabeth 
Published: July 2023

Abstract
Several factors that affect females across the life course are associated with risk for type 2 diabetes mellitus (T2DM), including genetics, parent-of-origin effects, the intrauterine environment, reproductive and pregnancy characteristics, and lifestyle and socioeconomic circumstances. Genome-wide association studies have identified many genetic variants involved in the pathogenesis of T2DM. The intrauterine environment, including maternal diabetes and adiposity, is an important risk factor for obesity and T2DM. Maternally expressed genes and matrilineal inheritance of mitochondrial DNA may play important roles in the excess maternal transmission of T2DM. Low birthweight, particularly when followed by accelerated postnatal growth, is associated with diabetes risk in adulthood. Puberty and pregnancy are other critical time points when increased insulin resistance may increase diabetes susceptibility. There appears to be a female predominance of youth-onset T2DM, which may reflect the role of sex steroids and/or socioenvironmental factors in the pathogenesis of T2DM. Gestational diabetes and/or multigravida increase T2DM risk, which may be due to gestational physiological changes and lifestyle behaviours. Reproductive factors, including age of menarche and menopause, as well as cycle length and regularity, are also implicated in T2DM risk. The relationship of socioeconomic status to diabetes risk varies between cultures, usually mirroring the prevailing socioeconomic patterns of obesity. A better understanding of the mechanisms involved in T2DM risk is needed to address the growing burden of T2DM, especially as T2DM is now increasingly affecting children. This chapter highlights important time points throughout a woman’s life course that may influence her risk of T2DM.