bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gd-EOB-DTPA-MRCP to localize bile leakage after liver trauma and surgery: impact on treatment and outcome
Authors: Marth Adrian A. , Auer Timo A. , Walter-Rittel Thula C. , Nevermann Nora , Krenzien Felix , Schmelzle Moritz , Müller Tobias , Kolck Johannes , Wieners Gero , Geisel Dominik , Gebauer Bernhard , Hamm Bernd , Schöning Wenzel , Fehrenbach Uli 
Published: April 2023

Abstract

Objectives
Bile leakage (BL) is a challenging complication after hepatobiliary surgery and liver trauma. Gadolinium ethoxybenzyl (Gd-EOB-DTPA)–enhanced magnetic resonance cholangiopancreatography (MRCP) is used to diagnose BL non-invasively. We assessed the value of Gd-EOB-DTPA-MRCP in the detection of postoperative and post-traumatic BL hypothesizing that exact identification of the leakage site is pivotal for treatment planning and outcome.

Methods
We retrospectively enrolled 39 trauma and postoperative patients who underwent Gd-EOB-DTPA-MRCP for suspected BL. Three readers rated the presence of BL and leakage site (intraparenchymal, central, peripheral ± aberrant or disconnected ducts). Imaging findings were compared to subsequent interventional procedures and their complexity and outcome.

Results
BL was detected in Gd-EOB-DTPA-MRCP in 25 of patients and was subsequently confirmed. Sites of BL differed significantly between postoperative (central [58%] and peripheral [42%]) and trauma patients (intraparenchymal [100%]; p < 0.001). Aberrant or disconnected ducts were diagnosed in 8%/26% of cases in the postoperative subgroup. Inter-rater agreement for the detection and localization of BL was almost perfect (Κ = 0.85 and 0.88; p < 0.001). Intraparenchymal BL required significantly less complex interventional procedures (p = 0.002), whereas hospitalization and mortality did not differ between the subgroups (p > 0.05).

Conclusions
Gd-EOB-DTPA-MRCP reliably detects and exactly locates BL in postoperative and trauma patients. Exact localization of biliary injuries enables specific treatment planning, as intraparenchymal leakages, which occur more frequently after trauma, require less complex interventions than central or peripheral leaks in the postoperative setting. As a result of specific treatment based on exact BL localization, there was no difference in the duration of hospitalization or mortality.

Clinical relevance statement
Gd-EOB-DTPA-MRCP is a reliable diagnostic tool for exactly localizing iatrogenic and post-traumatic biliary leakage. Its precise localization helps tailor local therapies for different injury patterns, resulting in comparable clinical outcomes despite varying treatments.

Key Points
• Gd-EOB-DTPA-MRCP enables adequate detection and localization of bile leakages in both postoperative and post-traumatic patients.
• The site of bile leakage significantly impacts the complexity of required additional interventions.
• Intraparenchymal bile leakage is commonly seen in patients with a history of liver trauma and requires less complex interventions than postoperative central or peripheral bile leakages, while hospitalization and mortality are similar.
Association between complete revascularization of the coronary artery and clinical outcomes in peripheral artery disease: a sub-analysis of the I-PAD Nagano registry
Authors: Kato Tamon , Ueki Yasushi , Minamisawa Masatoshi , Miura Takashi , Oyama Yushi , Hashizume Naoto , Yokota Daisuke , Taki Minami , Senda Keisuke , Okina Yoshiteru , Wakabayashi Tadamasa , Fujimori Koki , Karube Kenichi , Sakai Takahiro , Nomi Hidetomo , Yui Hisanori , Kanzaki Yusuke , Machida Keisuke , Maruyama Shusaku , Nagae Ayumu , Saigusa Tatsuya , Ebisawa Soichiro , Okada Ayako , Motoki Hirohiko , Kuwahara Koichiro ,   the I-PAD investigators
Published: April 2023

AbstractPeripheral artery disease (PAD) is commonly caused by atherosclerosis and has an unfavorable prognosis. Complete revascularization (CR) of the coronary artery reduces the risk of major adverse cardiovascular event (MACE) in patients with coronary artery disease (CAD). However, the impact of CR in patients with PAD has not been established to date. Therefore, we evaluated the impact of CR of CAD on the five-year clinical outcomes in patients with PAD. This study was based on a prospective, multicenter, observational registry in Japan. We enrolled 366 patients with PAD undergoing endovascular treatment. The primary endpoint was MACE, defined as a composite of all-cause death, non-fatal myocardial infarction, and non-fatal stroke. After excluding ineligible patients, 96 and 68 patients received complete revascularization of the coronary artery (CR group) and incomplete revascularization of the coronary artery (ICR group), respectively. Freedom from MACE in the CR group was significantly higher than in the ICR group at 5 years (66.7% vs 46.0%, p < 0.01). Multivariate analysis revealed that CR emerged as an independent predictor of MACE (Hazard ratio: 0.56, 95% confidential interval: 0.34–0.94, p = 0.03). CR of CAD was significantly associated with improved clinical outcomes in patients with PAD undergoing endovascular treatment.
Complications of reversible cerebral vasoconstriction syndrome in relation to age
Authors: Lange Kristin Sophie , Tuloup Gabrielle , Duflos Claire , Gobron Claire , Burcin Cécilia , Corti Lucas , Roos Caroline , Ducros Anne , Mawet Jérôme 
Published: April 2023

AbstractIntroductionReversible cerebral vasoconstriction syndrome (RCVS) has a heterogenous clinical and radiological presentation. We investigated whether RCVS complications vary according to age.Patients and methodsIn a pooled French cohort of 345 patients with RCVS, we assessed (1) rates of clinical and radiological complications, and (2) the functional outcome at 3 months according to age as a continuous variable, and in young patients aged ≤ 49 years versus those aged ≥ 50 years. TheCommission Nationale Informatique et Libertéand the local ethics committee approved this study (registration number: 202100733).ResultsThe risk for any focal deficit and for any brain lesion were independently associated with increasing age (OR 1.4, 95% CI 1.1–1.8;p = 0.014, and OR 1.6, 95% CI 1.2–2.1;p < 0.001, respectively). Subtypes of brain lesions independently associated with increasing age were subarachnoid haemorrhage (OR 1.7, 95% CI 1.3–2.3;p < 0.001) and intracerebral haemorrhage (OR 1.5, 95% CI 1.1–2.2;p = 0.023). Frequency of cervical artery dissections peaked at age 30–39, and young age was independently associated with cervical artery dissections (OR 13.6, 95% CI 2.4–76.6;p = 0.003). Age had no impact on the functional outcome, with a modified Rankin scale score of 0–1 in > 96% of patients.ConclusionAge seems to influence rates and types of complications of RCVS, with young age being associated with cervical artery dissections, and increasing age with haemorrhagic complications. If confirmed in larger prospective studies, recognition of age-specific patterns might help to guide clinical management and to identify complications in cases of RCVS and vice versa.
Premenarchal anorexia nervosa: clinical features, psychopharmacological interventions, and rehospitalization analysis in a 1-year follow-up, controlled study
Authors: Pruccoli Jacopo , Pugliano Rosa , Pranzetti Beatrice , Parmeggiani Antonia 
Published: April 2023

AbstractPremenarchal anorexia nervosa (AN) represents a specific subtype of AN, defined by an onset before the menarche in females, involving unique endocrine and prognostic features. The scarce data on this condition lack case–control and follow-up studies. This is a case–control, observational, naturalistic study, involving participants with premenarchal AN (premenarchal girls presenting to the study center newly diagnosed with AN) treated with a multidisciplinary hospital intervention, compared to postmenarchal AN individuals on clinical, endocrine, psychopathological, and treatment variables. The rate of rehospitalizations on a 1-year follow-up after discharge and respective prognostic factors were assessed with a Kaplan–Meier analysis and Cox regression model. The sample included 234 AN participants (43, 18.4% with premenarchal and 191, 81.6% with postmenarchal AN). When compared to postmenarchal, premenarchal AN individuals presented with lower depressive scores (Self-Administered Psychiatric Scales for Children and Adolescents (SAFA)) (U = 1387.0,p = 0.010) and lower luteinizing hormone (LH) levels (U = 3056.0,p = 0.009) and were less frequently treated with antidepressants (X2 = 5.927,p = 0.015). A significant predictive model of the risk of rehospitalization (X2 = 19.192,p = 0.004) identified a higher age at admission (B = 0.522,p = 0.020) and a day-hospital (vs inpatient) treatment (B = 3957,p = 0.007) as predictive factors for rehospitalization at 1-year, independent from the menarchal status. Conclusion: This study reports the clinical and treatment characteristics of premenarchal AN in one of the largest samples available in the current literature. Specific clinical features and prognostic factors for rehospitalization at 1-year follow-up were identified. Future studies should longitudinally investigate treatment-dependent modifications in endocrine and psychopathological measures in this population.What is Known:• Premenarchal Anorexia Nervosa (AN) is a subtype of AN characterized by its onset before menarche in females and is associated with unique endocrine and prognostic features.What is New:• Individuals with premenarchal AN may display specific clinical profiles, with lower depressive symptoms and luteinizing hormone levels than postmenarchal controls.
Mucosal injury during laparoscopic Heller cardiomyotomy: risk factors and impact on surgical outcomes
Authors: El-Magd El-Sayed Abou , Elgeidie Ahmed , Abbas Amr , Elmahdy Youssif , Abulazm Ibrahem Lotfy 
Published: April 2023

Abstract
Purpose
To investigate the risk factors and outcomes of mucosal perforation (MP) during laparoscopic Heller myotomy (LHM) in patients with achalasia.

Methods
We conducted a retrospective analysis of patients who underwent LHM for achalasia at a single facility.

Results
Among 412 patients who underwent LHM for achalasia, MP was identified in 52 (12.6%). Old age, long disease duration, low albumin level, an esophageal transverse diameter  > 6 cm, and a sigmoid-shaped esophagus were found to be independent predictors of MP. These factors were assigned a pre-operative score to predict the perforation risk. MP had a significant impact on intra and post-operative outcomes. Gastric side perforation was associated with a higher incidence of reflux symptoms, whereas esophageal-side perforation had a higher incidence of residual dysphagia.

Conclusions
Many risk factors for MP have been identified. Correctable parameters like low serum albumin should be resolved prior to surgery, while uncorrectable parameters like old age and a sigmoid-shaped esophagus should be managed by experienced surgeons in high-volume centers. Implementing these recommendations will help decrease the incidence and consequences of this serious complication.
Pet dogs (Canis familiaris) re-engage humans after joint activity
Authors: Byrne Molly , Horschler Daniel J. , Schmitt Mark , Johnston Angie M. 
Published: April 2023

AbstractJoint intentionality, the mutual understanding of shared goals or actions to partake in a common task, is considered an essential building block of theory of mind in humans. Domesticated dogs are unusually adept at comprehending human social cues and cooperating with humans, making it possible that they possess behavioral signatures of joint intentionality in interactions with humans. Horschler and colleagues (Anim Behav 183: 159–168, 2022) examined joint intentionality in a service dog population, finding that upon interruption of a joint experience, dogs preferentially re-engaged their former partner over a passive bystander, a behavior argued to be a signature of joint intentionality in human children. In the current study, we aimed to replicate and extend these results in pet dogs. One familiar person played with the dog and then abruptly stopped. We examined if dogs would preferentially re-engage the player instead of a familiar bystander who was also present. Consistent with the findings of Horschler and colleagues (Anim Behav 183: 159–168, 2022), pet dogs preferentially gazed toward and offered the toy to the player significantly more than the familiar bystander. However, no difference was observed in physical contact. These findings provide preliminary evidence for behavioral signatures of joint intentionality in pet dogs, but future work is needed to understand whether this phenomenon extends to other contexts.
Neural network expression rates and applications of the deep parametric PDE method in counterparty credit risk
Authors: Glau Kathrin , Wunderlich Linus 
Published: April 2023

AbstractThe recently introduced deep parametric PDE method combines the efficiency of deep learning for high-dimensional problems with the reliability of classical PDE models. The accuracy of the deep parametric PDE method is determined by the best-approximation property of neural networks. We provide (to the best of our knowledge) the first approximation results, which feature a dimension-independent rate of convergence for deep neural networks with a hyperbolic tangent as the activation function. Numerical results confirm that the deep parametric PDE method performs well in high-dimensional settings by presenting in a risk management problem of high interest for the financial industry.
Apoptotic Janus-faced mycotoxins against thoracal and breast metastases
Authors: Banfalvi Gaspar 
Published: April 2023

AbstractAbdominal organs (liver, kidney, spleen) are frequent targets of cancer cell invasion but their primary tumours are less known for their metastatic potential to other organs e.g. to the breast. Despite the known connection of the pathogenesis from breast cancer to liver metastasis, the study of the spread in the opposite direction has been neglected. The notion that breast cancer could be a metastasis besides being a primary tumour is based on rodents’ tumour models upon implantation of tumour cells under the capsule of the kidney or under the Glisson’s capsule of the liver of rats and mice. Tumour cells develop into a primary tumour at the site of subcutaneous implantation. The metastatic process starts with peripheral disruptions of blood vessels near the surface of primary tumours. Tumour cells released into the abdomen cross the apertures of the diaphragm, enter the thoracal lymph nodes and accumulate in parathymic lymph nodes. Abdominal colloidal carbon particles injected into the abdomen faithfully mimicked the migration of tumour cells and deposited in parathymic lymph nodes (PTNs). An explanation is provided why the connection between abdominal tumours and mammary tumours escaped attention, notably, parathymic lymph nodes in humans were referred to as internal mammary or parasternal lymph nodes. The apoptotic effect of Janus-faced cytotoxins is suggested to provide a new approach against the spread of abdominal primary tumours, and metastatic development.
P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway
Authors: Yu Yeping , Chang Ling , Hu Qingluan , Zhu Jianjun , Zhang Jianjun , Xia Qiang , Zhao Jie 
Published: April 2023

Abstract
Aims
Purinergic signaling-mediated mitochondria dysfunction and innate immune-mediated inflammation act as triggers during acetaminophen (APAP)-induced liver injury (AILI). However, the underlying mechanisms by which purinoceptor regulates mitochondria function and inflammation response in the progression of AILI remains unclear.

Methods
First, the hepatic level of purinergic receptor P2X 1 (P2RX1) was identified in the DILI patients and APAP-induced WT mice. P2rx1 knockout (KO) mice (P2rx1−/−) with 300 mg/kg APAP challenge were used for the analysis of the potential role of P2RX1 in the progression of AILI. Administration of DMX, the activator of stimulator of interferon genes (STING), was performed to investigate the effects of the STING-related pathway on APAP-treated P2rx1−/− mice.

Results
The elevated hepatic P2RX1 levels were found in DILI patients and the AILI mice. P2rx1 depletion offered protection against the initial stages of AILI, mainly by inhibiting cell death and promoting inflammation resolution, which was associated with alleviating mitochondria dysfunction. Mechanistically, P2rx1 depletion could inhibit STING-TANK-binding kinase 1 (TBK1)-P65 signaling pathways in vivo. We then showed that DMX-mediated STING activation could greatly aggravate the liver injury of P2rx1−/− mice treated with APAP.

Conclusion
Our data confirmed that P2RX1 was inducted during AILI, identified P2RX1 as a novel regulator in mitochondria dysfunction and STING pathways, and suggested a promising therapeutic approach for AILI involving the blockade of P2RX1.

Graphical abstract
1. It first demonstrated the protective effects of P2rx1 deficiency on acetaminophen-induced liver injury (AILI).
2. P2rx1 knockout alleviates mitochondria function and promotes inflammation resolution after APAP treatment.
3. It first reported the regulation of P2RX1 on the STING signaling pathway in the progress of AILI.
4. P2RX1 blockade is a promising therapeutic strategy for AILI.
Characterization of the water bodies of Extremadura (SW Spain)
Authors: Abdennour Mohamed Amine , Contador J. Francisco Lavado , González Jesús Barrena , Piccini Chiara , Landaverde Anthony Gabourel , Fernández Manuel Pulido 
Published: April 2023

AbstractExtremadura is the region that stores the greatest amount of fresh water in Spain. Such water is mainly used for power generation, irrigation in agriculture, biodiversity conservation, tourism, recreation, and human and livestock consumption. Nevertheless, crucial information on the total number of water bodies and their geometrical characteristics and spatial distribution patterns are still missing. Thus, our main goal was to characterize the Extremenian water bodies geometrically and spatially through different statistical techniques such as kernel density, Moran’s index, the Getis-Ord Gi*, and principal component analysis (PCA). Firstly, all existing hydrological information was gathered, and using aerial aircraft imagery and satellite images, each water body (WB) was then carefully collected, checked, and corrected. We have inventoried 100,614 WBs (mean density: 2.45 WB km2), irregularly distributed on the territory. WBs with an area < 0.01 km2 (100 ha) represent 64.5% of the total. A multivariate statistical study was conducted, showing that livestock, aridity of the climate, and topography are the main factors controlling the density of water bodies (WBs) in this area. It can be concluded that monitoring of small bodies is crucial to understand their spatial distribution, since they are spread over areas in which extensive farming and commercial crops such as tobacco strongly influence the way of living of many families.
Recursive inverse dynamics sensitivity analysis of open-tree-type multibody systems
Authors: Zhakatayev Altay , Rogovchenko Yuriy , Pätzold Matthias 
Published: April 2023

AbstractWe present a first-order recursive approach to sensitivity analysis based on the application of the direct differentiation method to the inverse Lagrangian dynamics of rigid multibody systems. Our method is simple and efficient and is characterized by the following features. Firstly, it describes the kinematics of multibody systems using branch connectivity graphs and joint-branch connectivity matrices. For most mechanical systems with an open-tree kinematic structure, this method turns out to be more efficient compared to other kinematic descriptions employing joint or link connectivity graphs. Secondly, a recursive sensitivity analysis is presented for a dynamic system with an open-tree kinematic structure and inverse dynamic equations described in terms of the Lagrangian formalism. Thirdly, known approaches to recursive inverse dynamic and sensitivity analyses are modified to include dynamic systems with external forces and torques acting simultaneously at all joints. Finally, the proposed method for sensitivity analysis is easy to implement and computationally efficient. It can be utilized to evaluate the derivatives of the dynamic equations of multibody systems in gradient-based optimization algorithms. It also allows less experienced users to perform sensitivity analyses using the power of high-level programming languages such as MATLAB. To illustrate the method, simulation results for a human body model are discussed. The shortcomings of the method and possible directions for future work are outlined.
Hermite least squares optimization: a modification of BOBYQA for optimization with limited derivative information
Authors: Fuhrländer Mona , Schöps Sebastian 
Published: April 2023

AbstractDerivative-free optimization tackles problems, where the derivatives of the objective function are unknown. However, in practical optimization problems, the derivatives of the objective function are often not available with respect to all optimization variables, but for some. In this work we propose the Hermite least squares optimization method: an optimization method, specialized for the case that some partial derivatives of the objective function are available and others are not. The main goal is to reduce the number of objective function calls compared to state of the art derivative-free solvers, while the convergence properties are maintained. The Hermite least squares method is a modification of Powell’s derivative-free BOBYQA algorithm. But instead of (underdetermined) interpolation for building the quadratic subproblem in each iteration, the training data is enriched with first and—if possible—second order derivatives and then least squares regression is used. Proofs for global convergence are discussed and numerical results are presented. Further, the applicability is verified for a realistic test case in the context of yield optimization. Numerical tests show that the Hermite least squares approach outperforms classic BOBYQA if half or more partial derivatives are available. In addition, it achieves more robustness and thus better performance in case of noisy objective functions.
Health-related quality of life 12 years after injury: prevalence and predictors of outcomes in a cohort of injured Māori
Authors: Maclennan Brett , Derrett Sarah , Wyeth Emma 
Published: April 2023

Abstract
Purpose
Studies have found that many people who sustain an injury can experience adverse outcomes for a considerable time thereafter. Māori, the Indigenous peoples of Aotearoa me Te Waipounamu (New Zealand; NZ), are no exception. The Prospective Outcomes of Injury Study (POIS) found that almost three-quarters of Māori participants were experiencing at least one of a range of poor outcomes at two years post-injury. The aim of this paper was to estimate the prevalence, and identify predictors, of adverse health-related quality of life (HRQoL) outcomes in the POIS-10 Māori cohort, 12 years after participants sustained an injury.

Methods
Interviewers reached 354 individuals who were eligible to participate in a POIS-10 Māori interview, to be conducted a decade after the last phase of POIS interviews (held 24 months post-injury). The outcomes of interest were responses to each of the five EQ-5D-5L dimensions at 12 years post-injury. Potential predictors (i.e., pre-injury sociodemographic and health measures; injury-related factors) were collected from earlier POIS interviews. Additional injury-related information was collected from administrative datasets proximate to the injury event 12 years prior.

Results
Predictors of 12-year HRQoL outcomes varied by EQ-5D-5L dimension. The most common predictors across dimensions were pre-injury chronic conditions and pre-injury living arrangements.

Conclusion
An approach to rehabilitation where health services proactively enquire about, and consider the broader aspects of, patient health and wellbeing throughout the injury recovery process, and effectively coordinate their patients’ care with other health and social services where necessary, may help improve long-term HRQoL outcomes for injured Māori.