bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trophoblastic infiltration of tubal pregnancy may have an association with chronic inflammation of the fallopian tube
Authors: Yan Li , Li Juan , Wang Yang , Zhu Qian , Zhao Xiaoya , He Chuqing , Zhu Chenfeng , Ji Sifan , Zhang Yiqin , MuDanLiFu HaLiSai , Zhang Jian 
Published: January 2023

AbstractObjectiveTo explore the factors associated with trophoblastic infiltration in ampullary pregnancy from the perspective of clinical and pathologic characteristics.MethodsA single‐center, retrospective, clinicopathologic cohort study was conducted in women who were diagnosed with tubal pregnancy and underwent salpingectomy in the International Peace Maternal and Child Health Care Hospital from January 2018 to June 2021.ResultsA total of 333 eligible women diagnosed with ampullary pregnancy were included in the analysis. Multivariate logistic analysis showed that preoperative β‐human chorionic gonadotropin greater than 3000 IU/L (adjusted odds ratio [aOR] 3.77, 95% confidence interval [CI] 2.02–7.03), and vascular remodeling phenomenon (aOR 4.34, 95% CI 2.41–7.83) were positively correlated with the infiltration of extravillous trophoblasts into serosa, while presence of chronic inflammation of the fallopian tube was a negatively corellated factor (aOR 0.49, 95% CI 0.29–0.85).ConclusionThe depth of trophoblastic infiltration in tubal pregnancy may be related to the presence of chronic inflammation in the fallopian tube. A tubal pregnancy in a tube with chronic salpingitis is more likely to develop into an abortive ectopic pregnancy; whereas in a fallopian tube without chronic inflammation, the risk of it developing into a ruptured ectopic pregnancy increases. Hence, early identification is needed to properly address this dangerous pregnancy situation.
Interval delivery of 5HT2A agonists using multilayered polymer films
Authors: Hossain Mehjabeen , Sulochana Suresh P. , Heath Katie E. , Bari Saif Mohammad Ishraq , Brewster Parker , Barnes Jared , Munivar Azim , Walker Glenn M. , Puleo David A. , Werfel Thomas A. 
Published: January 2023

AbstractThere is an urgent unmet medical need to develop therapeutic options for the ~50% of depression patients suffering from treatment‐resistant depression, which is difficult to treat with existing psycho‐ and pharmaco‐therapeutic options. Classical psychedelics, such as the 5HT2A agonists, have re‐emerged as a treatment paradigm for depression. Recent clinical trials highlight the potential effectiveness of 5HT2A agonists to improve mood and psychotherapeutic growth in treatment‐resistant depression patients, even in those who have failed a median of four previous medications in their lifetime. Moreover, microdosing could be a promising way to achieve long‐term alleviation of depression symptoms without a hallucinogenic experience. However, there are a gamut of practical barriers that stymie further investigation of microdosing 5HT2A agonists, including: low compliance with the complicated dosing regimen, high risk of diversion of controlled substances, and difficulty and cost administering the long‐term treatment regimens in controlled settings. Here, we developed a drug delivery system composed of multilayered cellulose acetate phthalate (CAP)/Pluronic F‐127 (P) films for the encapsulation and interval delivery of 5HT2A agonists from a fully biodegradable and biocompatible implant. CAPP film composition, thickness, and layering strategies were optimized, and we demonstrated three distinct pulses from the multilayered CAPP films in vitro. Additionally, the pharmacokinetics and biodistribution of the 5HT2A agonist 2,5‐Dimethoxy‐4‐iodoamphetamine (DOI) were quantified following the subcutaneous implantation of DOI‐loaded single and multilayered CAPP films. Our results demonstrate, for the first time, the interval delivery of psychedelics from an implantable drug delivery system and open the door to future studies into the therapeutic potential of psychedelic delivery.
Why do firms heap dividends? New evidence on the key role of firm characteristics
Authors: Rubio German , Jakob Keith , Castillo Augusto , Niño Jorge 
Published: January 2023

AbstractIn this paper we explore how a cognitive bias known as heaping (or rounding to a higher level) influences the dividend policy of companies. Recent articles have shown that dividend size and the level of several information uncertainty variables help to explain changes in the likelihood of rounding dividends. Using data from the US that covers the 1990–2020 period, we verify that the previous literature overlooked the key role played by a group of variables denominated as firm characteristics. These variables have already proven to have a role in the decision of paying dividends or not. We also show that other attributes, such as being regular payers of dividends, impact the likelihood of rounding dividends. Finally, we verify that the propensity to heap dividends has been changing over time, even after controlling for changes in the dividend size, in the level of the information uncertainty variables and in the status of the firm characteristic variables, opening space to further research.
A case of recurrent intracranial hemorrhage in CADASIL caused by NOTCH3 c.1759C>T heterozygous mutation
Authors: Chu Ying , Wang Qi , Ma Yue , Xu Linying , Ren Kexin , Liu Jiahui , Tao Dingbo , Cao Hua , Ji Xiaofei 
Published: January 2023

AbstractBackgroundCerebral autosomal‐dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebrovascular disease that is closely related to the NOTCH3 gene. Recurrent ischemic stroke, progressive cognitive dysfunction, and mental symptoms are the main clinical manifestations, whereas symptomatic intracranial hemorrhage is rare.MethodsWe detected a heterozygous mutation of c.1759C>T in exon 11 of the NOTCH3 gene that caused recurrent intracranial hemorrhage in CADASIL.ResultsSecond‐generation sequencing of a sample of the patient's genome revealed a heterozygous mutation of c.1759C>T in exon 11 of NOTCH3, which resulted in amino acid changes (p.R587C). This variation may be rated as a CADASIL clinical variation.ConclusionThe discovery of this mutation site provides an important theoretical basis for a gene‐based diagnosis and treatment of recurrent intracranial hemorrhage.
Minimum degree conditions for the existence of a sequence of cycles whose lengths differ by one or two
Authors: Chiba Shuya , Ota Katsuhiro , Yamashita Tomoki 
Published: January 2023

AbstractGao, Huo, Liu, and Ma proved a result on the existence of paths connecting specified two vertices whose lengths differ by one or two. By using this result, they settled two famous conjectures due to Thomassen. In this paper, we improve their result, and obtain a generalization of a result of Bondy and Vince.
Snow depth alteration and its relation with climate variability in China
Authors: Saydi Muattar , Tang Guoping , Ding Jianli , Wang Zhengang 
Published: January 2023

AbstractVarious climatic factors and their interactions affect China's snow depth alterations. However, a measure of the relative importance of climatic factors regarding the variance in snow depth is lacking. Here, we use a heretofore largest dataset, quality‐controlled daily observations from 1,665 meteorological stations, and statistical analyses to identify proxy drivers and their contributions regarding regional variability and trends in China's snow depth and snow depth‐climate relationships from 1951 to 2019. Results show that seasonal snow depth alterations are substantial in China and caused by various climatic drivers. In winter, observed positive trends in the northwest and northeast of China mainly respond to augmentation in solid precipitation and snow accumulation in fall. For the Tibetan Plateau, the negative snow depth anomaly seems to respond to the rising air temperature below the freezing point along with some secular changes in solid precipitation and shallower fall snowpacks. All these trends in winter snow depth over the northwest, northeast, and Tibetan Plateau of China account approximately for 30% of the total interannual variance in spring snow depth in these regions. In the milder central north and south of China, snow accumulation is not evident. Besides solid precipitation and rising air temperature below the freezing point, atmospheric humidity is also notable for its effect on the interannual variance in winter snow depth in these regions. In spring and fall, however, the negative effect of warming climate on snow depth becomes remarkably more important. It seems that about 13–33% (12–50%) of the total interannual variance in the widespread decrease (insignificant perturbation), except for some weak increases in the northeast region (decreases in the Tibetan Plateau), of China's spring (fall) snow depth are caused by the rising air temperature below the freezing point.
How should we handle predatory journals in evidence synthesis? A descriptive survey‐based cross‐sectional study of evidence synthesis experts
Authors: Barker Timothy H. , Pollock Danielle , Stone Jennifer C. , Klugar Miloslav , Scott Anna M. , Stern Cindy , Wiechula Rick , Shamseer Larissa , Aromataris Edoardo , Ross‐White Amanda , Munn Zachary 
Published: January 2023

AbstractSynthesizers of evidence are increasingly likely to encounter studies published in predatory journals during the evidence synthesis process. The evidence synthesis discipline is uniquely positioned to encounter novel concerns associated with predatory journals. The objective of this research was to explore the attitudes, opinions, and experiences of experts in the synthesis of evidence regarding predatory journals. Employing a descriptive survey‐based cross‐sectional study design, these experts were asked a series of questions regarding predatory journals to explore these attitudes, opinions, and experiences.Two hundred and sixty four evidence synthesis experts responded to this survey. Most respondents agreed with the definition of a predatory journal (86%), however several (19%) responded that this definition was difficult to apply practically. Many respondents believed that studies published in predatory journals are still eligible for inclusion into an evidence synthesis project. However, this was only after the study had been determined to be ‘high‐quality’ (39%) or if the results were validated (13%).While many respondents could identify common characteristics of these journals, there was still hesitancy regarding the appropriate methods to follow when considering including these studies into an evidence synthesis project.
Docosahexaenoic acid‐acylated astaxanthin monoester ameliorates chronic high‐fat diet‐induced autophagy dysfunction via ULK1 pathway in the hypothalamus of mice
Authors: Wang Xiaoxu , Cong Peixu , Wang Xincen , Wang Zhigao , Liu Bin , Xue Changhu , Xu Jie 
Published: January 2023

AbstractBackgroundDietary astaxanthin (AST) exhibits the ability to resist lipid accumulation and stimulate hepatic autophagy. Natural AST predominantly exists in stable esterified forms. More importantly, in our previous study, docosahexaenoic acid‐acylated AST monoester (AST‐DHA) possessed better stability, bioavailability, and neuroprotective ability than AST in free and diester form. However, the AST‐DHA mechanisms of action in regulating the obese phenotype and autophagy of the central nervous system remain unclear.ResultsHigh‐fat diet (HFD)‐fed C57BL/6J mice were orally administered AST‐DHA (50 mg/kg body weight/d) for 3 days or 8 weeks. AST‐DHA supplementation alleviated HFD‐induced abnormal body weight gain, significantly enhanced autophagy with an increased microtubule‐associated protein light chain 3 II/I (LC3II/I) ratio, and reduced the accumulation of p62/sequestosome 1 (SQSTM1) in the hypothalamus rather than in the hippocampus. Mechanistically, AST‐DHA effectively promoted autophagy and autophagosome formation, and most notably rescued the HFD‐impaired autophagosome‐lysosome fusion (indicated by the colocalization of LC3 and LAMP1) by regulating mTOR‐ and AMPK‐induced phosphorylation of ULK1. Consequently, AST‐DHA enhanced hypothalamic autophagy, leading to pro‐opiomelanocortin (POMC) cleavage to produce alpha‐melanocyte‐stimulating hormone (α‐MSH).ConclusionsThis study identified AST‐DHA as an enhancer of autophagy that plays a beneficial role in restoring hypothalamic autophagy, and as a new potential therapeutic agent against HFD‐induced obesity. © 2023 Society of Chemical Industry.
Outcomes of KTP Laser Ablation in Glottic Neoplasms: A Systematic Review and Meta‐Analysis
Authors: Suppah Mustafa , Kamal Abdallah , Karle William E. , Saadoun Rakan , Lott David G. 
Published: January 2023

ObjectivesTo evaluate the safety and clinical effectiveness of transoral laser microsurgery (TLM) with potassium‐titanyl‐phosphate (KTP) laser ablation for glottic neoplasms.Data SourceMEDLINE via PubMed, SCOPUS, Web of Science, and Cochrane Library.Review MethodsA systematic review and meta‐analysis of studies assessing the safety and efficacy of KTP laser therapy in patients with early‐stage glottic neoplasms.ResultsEight studies were included. After an average follow‐up of 3.3 years, the overall survival and disease‐free survival for patients who underwent KTP were 90.7% (95% CI 85%–96.5%) and 98.5% (95% CI 97.3%–99.8%), respectively. In the single‐arm meta‐analysis, the pooled estimate of recurrence was 7.7% (95% CI 3.4%–12%). The overall voice handicap index (VHI) estimate attributed to KTP in the single‐arm meta‐analysis was 6.76 (95% CI [3.05, 10.48]) and 5.21 (95% CI [2.86, 7.56]) within 6 months and after a one‐year follow‐up, respectively.ConclusionKTP laser ablation is a safe and effective method for treating patients with early glottic neoplasms. Laryngoscope, 133:1806–1814, 2023
Lp$L^p$ bound for the Hilbert transform along variable non‐flat curves
Authors: Wan Renhui 
Published: January 2023

AbstractWe prove the bound for the Hilbert transform along variable non‐flat curves , where α and β satisfy . Compared with the associated theorem in the work (Guo et al. Proc. Lond. Math. Soc. 2017) investigating the case , our result is more general while the proof is more involved. To achieve our goal, we divide the frequency of the objective function into three cases and take different strategies to control these cases. Furthermore, we need to introduce a “short” shift maximal function to establish some pointwise estimates.
Taylor's inequalities in Orlicz–Sobolev type spaces
Authors: Kovac Federico Dario , Levis Fabián Eduardo 
Published: January 2023

AbstractIn this paper, we obtain inequalities involving the Taylor polynomial and weak derivatives of a function in an Orlicz–Sobolev type space. Moreover, we show that any such function can be expanded in a finite Taylor series almost everywhere. As a consequence, we prove that the coefficients of any extended best polynomial ‐approximation of a function on a ball almost everywhere converge to the weak derivatives of such a function when the radius tends to 0. Lastly, we get a mean convergence result of such coefficients.
Essential finite generation of extensions of valuation rings
Authors: Datta Rankeya 
Published: January 2023

AbstractGiven a generically finite local extension of valuation rings , the question of whether W is the localization of a finitely generated V‐algebra is significant for approaches to the problem of local uniformization of valuations using ramification theory. Hagen Knaf proposed a characterization of when W is essentially of finite type over V in terms of classical invariants of the extension of associated valuations. Knaf's conjecture has been verified in important special cases by Cutkosky and Novacoski using local uniformization of Abhyankar valuations and resolution of singularities of excellent surfaces in arbitrary characteristic, and by Cutkosky for valuation rings of function fields of characteristic 0 using embedded resolution of singularities. In this paper, we prove Knaf's conjecture in full generality.
On the bands of the Schrödinger operator with a matrix potential
Authors: Veliev Oktay 
Published: January 2023

AbstractIn this article, we consider the one‐dimensional Schrödinger operator with a Hermitian periodic matrix potential Q. We investigate the bands and gaps of the spectrum and prove that most of the positive real axis is overlapped by m bands. Moreover, we find a condition on the potential Q for which the number of gaps in the spectrum of is finite.
March Madness prediction: Different machine learning approaches with non‐box score statistics
Authors: Kim Jun Woo , Magnusen Mar , Jeong Seunghoon 
Published: January 2023

AbstractThe popularity of analytical research specializing in forecasting of March Madness saw an increase in the past decades. While the influence of nongame statistics on the game outcome has become a great interest in sports analytics, little research has focused on situational factors in predicting sports tournament outcomes. Therefore, this study is to examine the use of different machine learning algorithms, including artificial neural network (ANN), k‐nearest neighbors (kNN), support vector machine (SVM), logistic regression, and random forest (RF), to forecast the winning in a matchup between any two given teams during the March Madness tournaments. Our data include 1370 observations with 685 tournament games from 2006 to 2007 to 2016 to 2017 seasons. The results show that neural networks outperformed all other classifiers (67% of accuracy), followed by SVM (65%), kNN (63%), logistic regression (63%), and RF (61%).
Acrylamide derivatives: A dynamic nuclear magnetic resonance study
Authors: Larina Lyudmila I. , Albanov Alexander I. , Zelinskiy Stanislav N. , Annenkov Vadim V. , Rusakova Irina L. 
Published: January 2023

AbstractSubstituted acrylamides have found an extensive application in organic and medical chemistry; therefore, it is very important to get insight into their features such as electronic structure, spectral properties, and stereochemical transformations. A correct interpretation of the chemical behavior and biological activity of these heteroatomic systems is impossible without knowledge of the structure of stereodynamic forms and factors determining their relative stability. The structure and peculiarities of stereodynamic behavior of substituted acrylamides and their model compounds were studied by dynamic and multinuclear1H,13C, and15N nuclear magnetic resonance (NMR) spectroscopy in CDCl3and DMSO‐d6solution. It has been established that acrylamides in solution are realized asZ‐ andE‐isomers, with theE‐rotamer being somewhat predominant. The obtained experimental values of the free activation energy of rotamers vary within 15–17 kcal/mol, depending on the stereochemical structure of the molecule.15N NMR spectroscopy is the most reliable and fastest method for determining the structural and stereochemical features of nitrogen‐containing compounds.
Psychometric evaluation of modified spinal muscular atrophy functional rating scale (SMAFRS) in adult patients using Rasch analysis
Authors: Sadjadi Reza , Kelly Kristina , Glanzman Allan M. , Montes Jacqueline , Linsenmayer Matthew , Tellez Marco , Bartlett Amy , Heintzman Sarah , Kolb Stephen J. , Arnold W. David , El‐Sheikh Bakri 
Published: January 2023

AbstractIntroduction/AimsThe Spinal Muscular Atrophy Functional Rating Scale (SMAFRS) was first developed as a secondary functional outcome measure to detect changes over time in patients with spinal muscular atrophy (SMA) in clinical trials. Its modified version evaluates 10 activities of daily living. The aim of the study was to analyze modified SMAFRS data using item response theory psychometric models.MethodsA total of 253 responses from 41 adult patients with ambulatory and non‐ambulatory SMA types 2, 3, and 4 were analyzed. Rasch analysis was used to explore item‐person targeting, fit statistics, category response functioning, dimensionality, and differential item functioning.ResultsMost items had good fitting with the exception of “toileting” and “respiratory.” There were no major floor or ceiling effects, and most items covered a good range of disability with only a negligible breech of uni‐dimensionality from eating, dressing, and respiratory items. Differential item function highlighted differences in toileting, turning, transferring, walking, and respiratory items between ambulatory and non‐ambulatory populations.DiscussionDespite subtle misfitting of certain items, mainly related to respiratory and bulbar function, overall modified SMAFRS remained a psychometrically stable and unidimensional outcome measure. There were some differences in measuring properties of certain functional items between ambulatory and non‐ambulatory items that need to be taken into consideration in clinical trial design. Overall, the modified SMAFRS is a psychometrically reliable tool in assessment of adult patients with SMA.
Synthesis and properties of COK‐12 large‐pore mesocellular silica foam
Authors: Henning Laura M. , Smales Glen J. , Colmenares Maria Gracia , Bekheet Maged F. , Simon Ulla , Gurlo Aleksander 
Published: January 2023

AbstractLarge, ink‐bottle‐shaped pores in mesocellular foams (MCFs) are desired for various applications requiring enhanced mass transfer or the immobilization of larger compounds. Hence, the cylindrical pores of COK‐12, an ordered mesoporous silica structurally comparable to SBA‐15 but synthesized at room‐temperature at quasi‐neutral pH, are chemically swollen into ink‐bottle pores. Therefore, p‐xylene is used as a more sustainable swelling agent compared to popular alternatives. Its high boiling point allows for an additional thermal aging step to amplify the mesostructure enlargement without needing additional chemicals. For COK‐12, the MCFs obtained at room temperature reach an unprecedented plateau for the modal mesopore cell and window diameter of 19.9 and 5.5 nm, respectively, with an underlying broad pore size distribution and distorted hexagonal lattice up to 14.5 nm, involving hexagonal and spherical structures. The combined chemical and thermal swelling resulted in the selective enlargement of the window diameter to more than 200% and a slightly increased cell diameter, pore size distribution, and hexagonal lattice distortion in comparison to the room temperature synthesis. Such materials are thought to be promising alternatives to SBA‐15‐based MCFs, often utilizing toxic catalysts during synthesis. The presented results pave the way for enhanced adsorptive, catalytic, and drug delivery performances for COK‐12‐based materials.
A novel CLAVATA1 mutation causes multilocularity in Brassica rapa
Authors: Chow Hiu Tung , Kendall Timmy , Mosher Rebecca A. 
Published: January 2023

AbstractLocules are the seed‐bearing structure of fruits. Multiple locules are associated with increased fruit size and seed set, and therefore, control of locule number is an important agronomic trait. Locule number is controlled in part by the CLAVATA‐WUSCHEL pathway. Disruption of either the CLAVATA1 receptor‐like kinase or its ligand CLAVATA3 can cause larger floral meristems and an increased number of locules. In an EMS mutagenized population of Brassica rapa, we identified a mutant allele that raises the number of locules from four to a range of from six to eight. Linkage mapping and genetic analysis support that the mutant phenotype is due to a missense mutation in a CLAVATA 1 (CLV1) homolog. In addition to increased locule number, additional internal gynoecia are formed in brclv1 individuals, suggesting a failure to terminate floral meristem development, which results in decreased seed production.