bluuebunny/crossref_metadata_2025_split huggingface dataset:
An object‐based method to study the life cycle of mesoscale convective systems and their environment from cloud‐resolving AROME‐France simulations
Authors: Arnould Gabriel , Montmerle Thibaut , Rottner Lucie , Moisselin Jean‐Marc 
Published: January 2025

AbstractAn object‐based methodology is used to study the mesoscale convective systems (MCSs) developing in France and the interactions they have with their environment during their life cycle. MCSs are detected from images of radar reflectivity and satellite 10.8‐ brightness temperature with a deep‐learning segmentation method. The ability of the Application of Research to Operations at Mesoscale (AROME‐France) numerical weather prediction model in representing MCSs is first assessed by comparing statistically the attributes of objects tracked in simulated and observed images of severe convective situations between 2018 and 2022. The MCS environment is then studied by averaging ambient variables simulated by AROME‐France within a 100‐km wide area and calculating original ring‐shaped composite maps adapted to the geometry of each object. Based on this methodology, it is shown that MCSs generally develop in unstable areas with low‐level convergence and strong wind aloft. Ambient instability correlates best with MCS severity and maintenance. It undergoes the greatest decrease throughout the life cycle, in relation with low‐level cooling and drying. Further comparisons are made between quasi‐stationary Mediterranean and other MCSs, and particular attention is paid to the impact of the system on its own environment. We finally emphasise three relevant predictors for MCS nowcasting in France: (1) the trend in system size and convective activity, (2) the ambient instability, and (3) the midlevel wind to anticipate MCS movement.
Synthesis of Small Molecule Library of Novel Nicotinamide Derivatives as Anticancer Agents and Computational Screening
Authors: Malothu Ram Mohan , Thalari Gangadhar 
Published: January 2025

AbstractA small molecule library of nicotinamide derivatives synthesized and characterized their structure by interpretation of 1H NMR, 13C NMR, and Mass spectral data. The new molecules were screened for their in vitro anticancer activity against human breast (MCF‐7) and cervical (HeLa) cell lines by using Doxorubicin as standard reference. Pyridine linked nicotinamide derivatives displayed potent activity against both the cell lines. The trifluoromethyl substituted pyridine analogue demonstrated outstanding activity with IC50 value of 8.70 ± 0.23 µM and 8.97 ± 0.31 µM against MCF‐7 and HeLa cell lines respectively, with respect to Doxorubicin IC50 value of 9.06 ± 0.36 µM (MCF‐7) and 9.17 ± 0.39 µM (HeLa). The compound 6 with thiomethyl group displayed activity with IC50 value of 9.01 ± 0.38 µM and 9.82 ± 0.41 µM against MCF‐7 and HeLa cell lines correspondingly. The methyl substituted compound 5h displayed encouraging activity with IC50 value of 10.47 ± 0.41 µM (MCF‐7) and 11.87 ± 0.45 µM (HeLa). Molecular docking study performed using potent molecules 5h , 5i, and 6 against estrogen receptor alpha (PDB ID: 3ERT), obtained highest docking score value for ligand 5i (9.5 kcal/mol). The predicted ADME of compounds indicated their drug‐like characteristics.
Silver Bio‐Nanoparticles Synthesis from Tetraclinis articulata Leaves Extract and Their Anti‐Inflammatory, Antioxidant, and Cytotoxicity Activities
Authors: Al Moudani Nada , Ouahidi Ibtissam , Laaraj Soukaina , Aarab Lotfi 
Published: January 2025

AbstractThe aim of this study was to explore the potential of bio‐silver nanoparticles (Ag‐NPs) synthesized from Tetraclinis articulata extract, a Moroccan plant, for the treatment of inflammatory diseases related to oxidative stress, such as arthritis, cardiovascular diseases and metabolic disorders. The objective was to reduce inflammation and neutralize free radicals by transferring the therapeutic properties of secondary metabolites of the plant to nanoparticles. The synthesis of Ag‐NPs was carried out by an environmentally friendly method, using exclusively the plant extract. The results showed that the formation of nanoparticles induced a dark brown color change, accompanied by an absorption peak at 450 nm in the UV‐visible spectrum, specific to nanoparticles. Scanning electron microscopy analysis revealed spherical nanoparticles of approximately 80 nm, and X‐ray spectroscopy confirmed the presence of silver. FTIR analysis identified phenolic compounds (flavonoids, polyphenols) and sugars, responsible for the reduction of silver ions and the stability of the nanoparticles. On the bioactive level, these nanoparticles showed a strong antioxidant and anti‐inflammatory potential, with an activity comparable to the control, without cellular toxicity, as confirmed by cell proliferation tests. These results open new perspectives for targeted therapeutic applications, highlighting the importance of sustainable synthesis methods.
The Push Toward Public Participation in the Governance of Industrial Safety Risks
Authors: Bieder Corinne , Laroche Hervé 
Published: January 2025

Abstract
This introductory chapter first provides a brief overview of the evolution of public participation in risk governance. Initially intended to strengthen accountability and empower citizens, civil society participation is now recognized as a component of decision-making processes in many areas of public life. The emergence of high-risk technologies and facilities has increased public interest in political and industrial decisions, and legislative efforts have been made to promote citizen participation. However, the implementation of public participation varies considerably between contexts and often falls short of expectations. Despite the challenges, there is growing recognition of the need for industrial companies and regulators to engage alongside the public in decision-making processes related to risk governance. This chapter highlights the complexities and contingencies involved in public participation and, as reflected in subsequent chapters, the importance of understanding diverse perspectives and approaches. Finally, in a second section, this introduction provides an outline of the chapters of the book.
Public Participation and the Democratic Imaginaries
Authors: Joly Pierre-Benoit , Bieder Corinne 
Published: January 2025

Abstract
Public participation has significantly developed since the 1980s. While public participation is commonly expected to bring better knowledge, better decision implementation and better democracy, the reality shows that it does not always lead to these benefits. This chapter provides explanations for this discrepancy between expected and observed benefits, by revealing the implicit assumptions and frameworks underpinning the diverse understandings of public participation. It identifies three axes along which these understandings differ. On the basis of this, it suggests a broader look at participation that allows to reach beyond its current flaws.
Decision Making in Projects Involving Public Participation
Authors: Laroche Hervé 
Published: January 2025

Abstract
Public participation in choices involving industrial risks may enrich the choice in many ways, but it also results in more complex, if not messy, decision making. The purpose of this chapter is to offer a general framework to account for the decision-making processes that unfold over time in connection with an industrial project and to situate public participation within these processes. I build on the “garbage can model” of decision-making, a famous and provocative conceptualization that has generated a thread of research in organization studies and political science. Decision making is understood as resulting from the encounters of problems and solutions supported by a number of participants with varying degrees of involvement in the decision. The encounters are regulated by organizational arrangements that filter the flow of participants, problems and solutions. What constitutes a good or bad regulation is discussed in the conclusion.
Konklusion und Systematisierung
Authors: Sehmer Julian 
Published: January 2025

Zusammenfassung
Unter der Überschrift „Konklusion und Systematisierung“ leistet dieses Kapitel eine Ordnung der Erkenntnisse aus der Rekonstruktion der untersuchten Eckfälle im vorangegangenen Kapitel. Diese werden dabei nicht mehr vollständig in Bezug auf die einzelnen Eckfälle wiederholt, sondern gebündelt und systematisiert. Herausgearbeitet werden so eckfallübergreifende Strukturen, Muster und Ordnungen des Feldes. Diese Systematisierung der gewonnenen Erkenntnisse bildet in Ergänzung der Forschungsheuristik aus Kapitel 9 das gegenstandsverankerte theoretische Konzept zur Bedeutung und (Re)Produktion sozialer Normen innerhalb der Logik der untersuchten sozialpädagogischen Praxis.
Statt eines Fazits: Beiträge und Begrenzungen reflexiv-zirkulärer Forschung
Authors: Sehmer Julian 
Published: January 2025

Zusammenfassung
Den Ausgangspunkt der Beschäftigung mit der kinderschutzbezogenen Handlungs- und Forschungspraxis bildete die Feststellung, dass empirische Studien im Kinderschutz immer wieder ähnliche Defizitdiagnosen produzieren und wiederholt ähnliche Erkenntnisse formulieren. Gefragt wurde, ob dabei nicht möglicherweise systematisch spezifische Aspekte der Praxis ausgeblendet werden, die empirisch nicht weiter aufgeklärt werden können und so auch eine Kontextualisierung und empirische Entschlüsselung feldspezifischer Logiken unterbleiben. Mit der vorliegenden Arbeit und den beiden Teilstudien wurde das Vorhaben unternommen, eine Heuristik zu entwickeln, die es ermöglicht, eine spezifische Fehlstelle in der Beforschung der sozialpädagogischen Kinderschutzpraxis aufzuklären: die Bedeutung und (Re)Produktion sozialer Normen für sozialpädagogische Praxen und Praxis.
Erste Zugänge
Authors: Sehmer Julian 
Published: January 2025

Zusammenfassung
Die vorliegende Studie orientiert sich in ihrem Vorgehen an der Ethnographie als Forschungshaltung respektive -strategie und verbindet diese mit den Grundprinzipien der Grounded Theory Methodologie (GTM) sowie der Sequenzanalyse als Instrument systematisch regelgeleiteter Rekonstruktion. Die Stärke von Ethnographie und GTM liegt dabei neben der konsequenten Ausrichtung am Gegenstand und der Möglichkeit der Organisation komplexer Datenanalysen insbesondere in der stringenten Verschränkung von empirischer Forschung und Theoriegenerierung in einem zirkulären Analyseprozess.
Dekonstruktion
Authors: Sehmer Julian 
Published: January 2025

Zusammenfassung
Auf Basis der Erkenntnisse aus der explorativen Teilstudie und dem Vorschlag von Alexandra Retkowski, Barbara Schäuble und Werner Thole (2012b) folgend, geht es in der vorliegenden Dekonstruktion darum, forschungsmethodische und theoretische Zugänge zu identifizieren und zu systematisieren, die sich zunächst von professionellen Folien und Modellen des Pädagogischen distanzieren oder explizit verabschieden und Zugänge zur Praxis und darin eingelagerter Normen anbieten. Das vorliegende Kapitel ist dabei weder als Aufarbeitung des Forschungsstandes im genuinen Sinn konzipiert, noch geht es darum, die Argumente der einzelnen Perspektiven unmittelbar zu einer kohärenten Systematik im Sinne einer forschungstheoretischen Ausarbeitung zu verknüpfen. Es soll vielmehr als Metaanalyse verstanden werden, deren Gegenstand Ansätze respektive Forschungsprogramme sind, die sich mit unterschiedlichen Ausgangslagen und Grundprämissen der Herausforderung widmen, (sozial)pädagogische Praktiken in ihren jeweiligen Eigenlogiken zu untersuchen und dabei soziale Normen oder normative Bezüge berücksichtigen, ohne diese unmittelbar und ausschließlich an professions-, organisations- und evidenztheoretischen Modellen abzugleichen.
BRAT1 - a new therapeutic target for glioblastoma
Authors: Haydo Alicia , Schmidt Jennifer , Crider Alisha , Kögler Tim , Ertl Johanna , Hehlgans Stephanie , Hoffmann Marina E. , Rathore Rajeshwari , Güllülü Ömer , Wang Yecheng , Zhang Xiangke , Herold-Mende Christel , Pampaloni Francesco , Tegeder Irmgard , Dikic Ivan , Dai Mingji , Rödel Franz , Kögel Donat , Linder Benedikt 
Published: January 2025

Abstract
Glioblastoma (GBM), the most malignant primary brain tumor in adults, has poor prognosis irrespective of therapeutic advances due to its radio-resistance and infiltrative growth into brain tissue. The present study assessed functions and putative druggability of BRCA1-associated ATM activator 1 (BRAT1) as a crucial factor driving key aspects of GBM, including enhanced DNA damage response and tumor migration. By a stable depletion of BRAT1 in GBM and glioma stem-like (GSC) cell lines, we observed a delay in DNA double-strand break repair and increased sensitivity to radiation treatment, corroborated by in vitro and in vivo studies demonstrating impaired tumor growth and invasion. Proteomic and phosphoproteomic analyses further emphasize the role of BRAT1’s cell migration and invasion capacity, with a notable proportion of downregulated proteins associated with these processes. In line with the genetic manipulation, we found that treatment with the BRAT1 inhibitor Curcusone D (CurD) significantly reduced GSC migration and invasion in an ex vivo slice culture model, particularly when combined with irradiation, resulting in a synergistic inhibition of tumor growth and infiltration. Our results reveal that BRAT1 contributes to GBM growth and invasion and suggest that therapeutic inhibition of BRAT1 with CurD or similar compounds might constitute a novel approach for anti-GBM directed treatments.
Tumour growth rate and invasive interval cancer characteristics in a UK breast cancer screening population
Authors: Nanaa Muzna , Manavaki Roido , van Nijnatten Thiemo J. A. , Stranz Natalia , Carriero Serena , Coleman William A. , Allajbeu Iris , Payne Nicholas R. , Giannotti Elisabetta , Hickman Sarah E. , Arponen Otso , Gilbert Fiona J. 
Published: January 2025

Abstract

Objectives
To estimate tumour volume doubling time (TVDT) of interval cancers (ICs).

Methods
Two radiologists retrospectively reviewed prior screening and diagnostic mammograms and measured mean diameter on “visible” ICs. Univariate analyses of clinicopathological variables (ER, HER2, grade, age at diagnosis, and breast density) were undertaken, and those with p < 0.1 were included in a generalised linear model to estimate TVDT, cancer size at screening, and time of cancer visibility for “non-visible” tumours.

Results
From 2011 to 2018, 476 ICs were diagnosed, almost half in the third year after screening with 86% grade 2 or 3. A visible abnormality at screening was identified in 281/476 (59%) cases. Significant differences in TVDT were found with age (p < 0.02), ER status (p < 0.0001). Median TVDTs of grade 1, 2 and 3 cancers were 317, 288, and 195 days, respectively (p < 0.001). For non-visible cancers, the median estimated size at screening was 1.7 mm (IQR 1.0–2.5) for grade 1, 2.5 mm (IQR 1.5–5.9) for grade 2, and 0.9 mm (IQR 0.4–2.0) for grade 3 cancers, p < 0.001. The estimated time for cancer visibility was 489 days (IQR 229–682) after screening and 645 days (IQR 527–798) for cancers diagnosed in the third year after screening.

Conclusion
Using TVDT of retrospectively visible interval cancers, non-visible interval cancer sizes can be estimated at the time of screening. Increasing the frequency of screening from three-yearly to two-yearly invitations would reduce the number of interval cancers significantly.

Key Points

Question

Growth modelling of visible interval cancers (ICs) at screening helps to track the likely progression of non-visible ICs over the screening interval.

Findings

Tumour doubling time of visible ICs at screening is positively associated with age and ER status and inversely associated with cancer grade.

Clinical relevance

Interval cancer characterisation and growth modelling can be helpful to better predict the benefits of supplemental screening and the frequency of screening, given a minimum detectable size.
Evaluation of MRI characterisation of histopathologically matched lymph nodes and other mesorectal nodal structures in rectal cancer
Authors: Rutegård Miriam Kheira , Båtsman Malin , Blomqvist Lennart , Rutegård Martin , Axelsson Jan , Wu Wendy , Ljuslinder Ingrid , Rutegård Jörgen , Palmqvist Richard , Brännström Fredrik , Riklund Katrine 
Published: January 2025

Abstract

Purpose
To evaluate current MRI-based criteria for malignancy in mesorectal nodal structures in rectal cancer.

Method
Mesorectal nodal structures identified on baseline MRI as lymph nodes were anatomically compared to their corresponding structures histopathologically, reported as lymph nodes, tumour deposits or extramural venous invasion. All anatomically matched nodal structures from patients with primary surgery and all malignant nodal structures from patients with neoadjuvant treatment were included. Mixed-effects logistic regression models were used to evaluate the morphological criteria irregular margin, round shape, heterogeneous signal and nodal size, as well as the combined 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus criteria, with histopathological nodal status as the gold standard.

Results
In total, 458 matched nodal structures were included from 46 patients (mean age, 67.7 years ± 1.5 [SD], 27 men), of which 19 received neoadjuvant treatment. The strongest associations in the univariable model were found for short-axis diameter ≥ 5 mm (OR 21.43; 95% CI: 4.13–111.29, p < 0.001) and heterogeneous signal (OR 9.02; 95% CI: 1.33–61.08, p = 0.024). Only size remained significant in multivariable analysis (OR 12.32; 95% CI: 2.03–74.57, p = 0.006). When applying the ESGAR consensus criteria to create a binary classification of nodal status, the OR of malignant outcome for nodes with positive ESGAR was 8.23 (95% CI: 2.15–31.50, p = 0.002), with corresponding sensitivity and specificity of 54% and 85%, respectively.

Conclusion
The results confirm the role of morphological and size criteria in predicting lymph node metastases. However, the current criteria might not be accurate enough for nodal staging.

Key Points

Question

Pretreatment lymph node staging in rectal cancer is challenging, and the ESGAR consensus criteria are not fully validated.

Findings

Although the ESGAR criteria correlated with malignant outcomes, diagnostic performance in terms of particular sensitivity, but also specificity, was not high.

Clinical relevance

Accurate nodal staging in rectal cancer is crucial for individual treatment planning. However, this validation of the current ESGAR consensus criteria suggests that these should be used with caution.
Growth-associated and Non-growth-associated Bioethanol Production Kinetics from Nanoadsorbent-Detoxified Pretreated Hydrolysate
Authors: Adebule Adeniyi P. , Sanusi Isaac A. , Kana Gueguim E. B. 
Published: January 2025

Abstract
Lignocellulosic-based (LCB) bioethanol production is challenged by the presence of inhibitory compounds in pretreated LCB hydrolysates limiting productivity. The negative impact of these inhibitory compounds on LCB bioethanol production kinetics remain understudied. Hence, this study modelled the kinetics of bioethanol fermentation using nanoadsorbent-detoxified potato peel waste (PPW) hydrolysate. Four different fermentation processes under both separate hydrolysis and fermentation (SHF) and simultaneous saccharification and fermentation (SSF) conditions, including A (SHF with non-detoxified hydrolysate), B (SSF with non-detoxified hydrolysate), C (SHF with detoxified hydrolysate), and D (SSF with detoxified hydrolysate) were evaluated for bioethanol productivity. Higher productivity of 1.23 and 1.16-fold increments were recorded for fermentation processes C and D. Thereafter, the experimental data for cell growth, bioethanol production and substrate utilisation were well-fitted by the logistic function, modified Gompertz, and Luedeking-Piret models respectively. Moreover, the obtained root-mean-square error (RMSE) and mean square error (MSE) were low, while the accuracy factor (AF), bias factor (BF), slope and regression coefficient (R2) were close to 1. The bioethanol production processes were largely growth-associated (α) as α values (g ethanol/g substrate) were higher than β values (g ethanol/g substrate/h). The models were effectively implemented, demonstrating their usefulness to elucidate bioethanol productivity kinetics for improved process design and the development of large-scale bioethanol production.

Graphical Abstract
Measuring What Outcomes Matters Most to People When Accessing Suicide Postvention Support: A Qualitative Study
Authors: Jackson Bess , Wayland Sarah , Ball Shelley-Anne , Maple Myfanwy 
Published: January 2025

Abstract
Funding for suicide postvention services, which provide support after a suicide death, has increased in Australia and globally. This rise accompanies a need to demonstrate outcomes of support. However, articulating and quantifying these outcomes presents ethical and logistical challenges. Funders' priorities may differ from those of service users. To discern the value and explore effective measurement of postvention outcomes, focus groups were conducted with postvention staff and lived experience representatives from an Australian postvention service. Transcripts were analysed using Braun and Clarke’s Reflexive Thematic Analysis. Results highlighted the complex context of measuring outcomes in suicide postvention and emphasized the need for flexible approaches to service provision and outcome measurement. The study suggests that the most significant benefits, as perceived by participants, are the ‘flow-on’ effects of postvention. It supports the notion that outcome measures require careful consideration, with trade-offs evaluated to understand what is truly valuable in suicide postvention services.
Effect of the 5E model enriched with coding and digital game design activities on gifted students' academic achievement and problem-solving skills
Authors: Bozan Ibrahim , Taslidere Erdal 
Published: January 2025

Abstract
Coding and digital game design activities have been used in recent years to contribute to students' academic achievement and twenty-first century skills. This study aimed to investigate the effect of the 5E model enriched with coding and digital game design activities (5EECD) on gifted students' academic achievement and problem-solving skills. A quasi-experimental design with pre-test post-test control group was used in the research. The sample of the study consists of 80 3rd grade gifted primary school students studying at a Science and Art Center affiliated to the Ministry of National Education in Türkiye. The study was completed in a five-week treatment period. The experimental group studied the force and motion concept with the 5EECD and the control group studied it with the proposed conventional method. Academic Achievement Test and Problem-Solving Skills Scale were used as pre and post-tests as measuring tools. The data were analyzed by descriptive and inferential statistics. The descriptive statistics results revealed that the experimental group students showed higher performances in science achievement and problem-solving skills. Inferentially, MANCOVA results showed that the 5EECD had a statistically significant effect on the collective dependent variables of the academic achievement and problem-solving skills. The ANCOVA findings also supported the above outcomes and it indicated that each of the academic achievement and problem-solving skills of experimental group was significantly higher than those of the control group. Therefore, the findings of the current research suggest that the 5EECD would be used for 3rd grade gifted students’ science education.