bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solving problem of encountering a huge cavern in a TBM drive for water diversion tunnel project in Northern Thailand
Authors: Harnpattanapanich Thanu , Phienwej Noppadol , Rodploy Jitaphol , Monthanopparat Nantapol , Tanomtin Chawalit , Kongdang Koson 
Published: June 2023

AbstractA huge cavern in a zone of thrusted and sheared clastic sedimentary rocks was encountered during drill and blast (D&B) and tunnel boring machine (TBM) excavation of water transfer tunnel in Thailand. The cavern floor made of thick and loose pile of fallen rock blocks hampered the advance of the TBM through it. Because the size of the cavern was large (50 m × 40 m) and the extent of the thickness of the pile of rock blocks could not be precisely determined, the adopted ramification was to solidify a zone of loose rock fragments around the tunnel alignment. This measure is to allow a safe TBM excavation passing the cavern and ensure the long‐term function of the segmented concrete‐lined tunnel to convey water without problem of loss from subsidence damage. The scheme of the solidification consisted of staged grouting that began with polyurethane (PU) foam grouting to form a bottom barrier of the intended cement grout zone. It was followed large void filling by flowable concrete and then cement injection for the remaining smaller voids. The work that took 8 months to complete started with the excavation of a bypass adit to the front of TBM cutterhead as an access to the cavern and the installation of dewatering and ventilation systems to the cavern so that the grouting work could be made.
Challenges in design and construction of Bangkok MRT Orange Line project
Authors: Kitiyodom Pastsakorn , Wiriyatharakij Woraphon , Asanprakit Auttakit , Yamchoo Anucha 
Published: June 2023

AbstractThe MRT Orange Line construction works in Bangkok are more complicated than works in earlier projects. As the tunnel alignment passes through the congested urban areas in the city, it either clashes with or passes beneath several existing structures. Underpinning works are then required. Assessment of movement of ground and structure plays an important role in the project. The rebound of piezometric pressure in sand layers that is being developed poses a major point of difficulty in the excavation and underground structure design and construction. Groundwater control measures become a crucial issue in MRT Orange Line project that leads to difficulties in deep MRT station excavations. To control base instability, various methods (e.g., cut‐off wall, staged excavation) are introduced and presented in this article.
Too smart to work hard? Investigating why overqualified employees engage in time theft behaviors
Authors: Zhao Sijia , Ma Chao 
Published: June 2023

AbstractIntegrating the theory of workplace deviance with person–environment fit theory, we propose a two‐pathway model to explain why and how employees who feel overqualified engage in time theft behavior. Specifically, we anticipate that feeling overqualified will negatively influence focal employees' experienced authority fairness and erode their work meaningfulness, which in turn will lead to increased time theft behavior. Further, we argue that voice endorsement serves as a key boundary condition mitigating the negative effects of perceived overqualification. We conducted two multi‐waved and multi‐sourced field studies to test our proposed hypotheses. Study 1 (247 employees and 47 supervisors) revealed that perceived overqualification is associated with time theft behavior through the mediators of experienced authority fairness and meaningfulness. Study 2 (405 employees and 73 supervisors) replicated the findings of Study 1 and tested our full model. We discuss the theoretical and practical implications of our findings.
Variation in prescribing for the prevention of postoperative nausea, vomiting, and pain following abdominal surgery: A retrospective study
Authors: Kelly Sarah M. , Quenby Miranda , Corcoran Tomás B , Webb Steven , Cohen Paul A. 
Published: June 2023

AbstractBackground and AimsAdequate postoperative analgesia and prevention of post‐op nausea and vomiting (PONV) are core components of modern day anaesthesia and peri‐operative care. As well as contributing to overall morbidity, postoperative pain and PONV are frequently cited as one of the most unpleasant and distressing aspects of surgery for patients. Variation in healthcare delivery is known to exist but has often been poorly described. A first step to understanding the consequences of variation is to describe the extent of variation. We aimed to assess variation in pharmacological strategies to prevent postoperative pain, nausea and vomiting in patients undergoing elective major abdominal surgery at a tertiary hospital in Perth, Western Australia, over a three‐month period.MethodsRetrospective cross‐sectional study.ResultsWe observed considerable variation in prescribing of postoperative analgesia and PONV prophylaxis and suggest that despite adequate evidence based guidelines, they are often overlooked in practice.ConclusionMeasurement of the consequences of variation requires randomised clinical trials that evaluate differences in outcome and cost, associated with the strategies that exist within the spectrum of variation.
Heat and mass transfer effects on fluid past an exponentially accelerated vertical plate due to time‐fractional MHD‐free convection
Authors: Vanav Kumar A. , Jino L. , Jacob Ashwin , Doley Swapnali , Pegu Jhandesh 
Published: June 2023

AbstractThis article focuses on the study of heat and mass transfer (HMT) fluid flow over an exponentially accelerated vertical plate, which is subjected to an applied magnetic field and viscous dissipation. The research has applications in various manufacturing processes such as wire/fiber drawing, hot rolling, continuous casting, and hot extrusion, where heat transfer to the ambient medium and the hot moving material are of utmost importance. The findings could also be relevant to aerospace engineering applications. The study investigates the time‐fractional natural convection phenomenon and utilizes conservation laws to derive the flow guiding equations, which are then made nondimensional. Finite difference discretization is utilized to solve the dimensionless equations implicitly. Then the flow simulation results such as concentration, temperature, and velocity profiles are discussed based on the variation in parameters such as Prandtl number (), thermal/mass Grashof number (), Eckert number (), magnetic parameter (), time‐fractional order (), and Schmidt number . Also, the HMT rate is depicted using the Nusselt number and skin friction plots. It is noted that HMT increases when increases and decreases. The change in time‐fractional order affects the velocity profiles adjacent to the wall and is more significant in the case of lower values of the Prandtl number.
Cord blood antibodies following BBIBP‐CorV (Sinopharm) vaccination during pregnancy
Authors: Hantoushzadeh Sedigheh , Eshraghi Nasim , Younesi Sarang , Salehi Mohammadreza , Rezaei Nima , Hasheminejad Mohammad Mehdi , Rashidian Pegah , Shirdel Saeedeh , Asadi Fatemeh , Ghaemi Marjan 
Published: June 2023

AbstractObjectiveThis study aimed to evaluate the maternal and umbilical cord blood antibody levels, after COVID vaccination during pregnancy.MethodThe women who received the COVID‐19 vaccine (Sinopharm) during pregnancy were included. Maternal and cord blood samples were tested to detect the severe acute respiratory syndrome coronavirus 2 receptor binding domain (RBD) specific antibodies. In addition, obstetric information and side effects after vaccination were gathered.ResultA total of 23 women were included. Eleven pregnant women took two doses and 12 cases received a single dose of the vaccine. No IgM antibody was detected in any maternal blood or cord blood samples. The RBD‐specific Immunoglobulin G (IgG) antibody was positive in mothers receiving 2 doses of the vaccine and their infants. But the antibody titers were under the positive cut‐off threshold for the other 12 women who were vaccinated with a single dose. Women who received both doses of vaccine had significantly higher IgG levels than a single dose of Sinopharm (p = .025). The same result was demonstrated in infants born to these mothers (p = .019).ConclusionThere was a significant correlation between maternal and neonatal IgG concentrations. Although, receiving both doses of the BBIBP‐CorV vaccine (not 1 dose) during pregnancy is highly beneficial for increasing humoral immunity for the mother and fetus.
Case report: Successful treatment of anti‐MDA5‐positive to negative dermatomyositis‐associated interstitial lung disease with the JAK inhibitor tofacitinib
Authors: Jiang Zong , Yao Xiaoling , Tang Fang , Ma Wukai 
Published: June 2023

AbstractObjectiveAnti‐MDA5 antibody‐positive dermatomyositis (DM) is a rare clinical autoimmune disease, and anti‐MDA5‐positive DM with interstitial lung disease (ILD) is the most important cause of death in DM patients. We reported the efficacy of the JAK1/3 inhibitor tofacitinib as an anti‐MDA5‐negative treatment option for patients with anti‐MDA5‐positive DM‐ILD.Method and processHere we report a 51‐year‐old female patient with cough, sputum, shortness of breath for 5 months, rash for 3 months, and muscle pain in the extremities for 1 month. After conventional immunosuppressive therapy plus hormone therapy, the remission was slow. Methylprednisolone was successfully reduced after we administered tofacitinib and tacrolimus. After 132 weeks of follow‐up, anti‐MDA5 antibody turned negative, clinical symptoms were relieved, and lung Imaging tests were successfully reversed.Results and ConclusionThere is currently no report of tofacitinib supplement therapy for anti‐MDA5 positive to negative DM. With this case report, tofacitinib is an option for the treatment of anti‐MDA5‐positive DM‐ILD, which deserves attention.
Acceptance, availability, and feasibility of RTS, S/AS01 malaria vaccine: A review
Authors: Mumtaz Hassan , Nadeem Abdullah , Bilal Wajeeha , Ansar Farrukh , Saleem Saira , Khan Qaisar Ali , Tango Tamara , Farkouh Christopher , Belay Naod F. , Verma Ravina , Farkouh Matthew , Saqib Muhammad 
Published: June 2023

AbstractIntroductionIn malaria‐stricken regions, malaria continues to be one of the primary causes of mortality for children. The number of malaria‐related fatalities has drastically decreased because of artemisinin‐based pharmacological regimens.MethodsTwo independent researchers did a comprehensive literature search using PubMed/MEDLINE and Google Scholar from its inception to September 2022.ResultsAfter evaluating RTS, S/AS01 for its safety, effectiveness, and feasibility, the European Medicines Agency (EMA) issued a favorable conclusion. It was suggested that the RTS, S malaria vaccine be used extensively by the World Health Organization on October 6, 2021. The successful pilot program testing the malaria vaccine in Ghana, Kenya, and Malawi served as the basis for this proposal.ConclusionSeveral challenges need to be addressed to ensure the success of vaccination programs. From the acceptability perspective, issues such as inadequate community engagement, concerns about side effects, and issues with the delivery and quality of healthcare services can affect the acceptance of the vaccine. From the feasibility standpoint, factors such as lack of transportation or long distances to healthcare facilities and the perception of completion of the vaccination calendar can affect the feasibility of the vaccine. Lastly, the availability of the vaccine is also a major concern as it may not be readily available to meet the demands.
Epimedium sagittatum Maxim ameliorates adriamycin‐induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathway
Authors: Wang Ru , Zeng Mengnan , Zhang Beibei , Zhang Qinqin , Xie Shuangshuang , Hu Yingbo , Fan Ruyi , Wang Mengya , Yu Xiao , Zhang Yuhan , Zheng Xiaoke , Feng Weisheng 
Published: June 2023

AbstractBackgroundModern pharmacological studies show that Epimedium sagittatum Maxim (EPI) has antioxidant, antiapoptotic, anti‐inflammatory effects. However, the effects of EPI on adriamycin‐induced nephropathy are unclear.AimThe main purpose of this study is to investigate the effects of EPI on adriamycin‐induced nephropathy in rats.MethodsThe chemical composition of EPI was detected by high performance liquid chromatography. Network pharmacology was used to collect the effects of EPI on adriamycin nephropathy; renal histological changes, podocyte injury, inflammatory factors, oxidative stress levels, apoptosis levels, and the PI3K/AKT signaling pathway were examined. Moreover, analyze the effects of icariin (the representative component of EPI) on adriamycin‐induced apoptosis and PI3K/AKT signaling pathway of NRK‐52e cells.ResultsNetwork pharmacological results suggested that EPI may ameliorate adriamycin‐induced nephropathy by inhibiting inflammatory response and regulating the PI3K/AKT signaling pathway. The experimental results showed that EPI could improve pathological injury, renal function, podocyte injury, and inhibit inflammation, oxidative stress, apoptosis in adriamycin‐induced nephropathy rats through the PI3K/AKT signaling pathway. Furthermore, icariin inhibited adriamycin‐induced mitochondrial apoptosis in NRK‐52e cells.ConclusionThis study suggested that EPI ameliorates adriamycin‐induced nephropathy by reducing inflammation and apoptosis through the PI3K/AKT signaling pathway, icariin may be the pharmacodynamic substance basis for this effect.
Long noncoding RNA00324 is involved in the inflammation of rheumatoid arthritis by targeting miR‐10a‐5p via the NF‐κB pathway
Authors: Xie Binbin , Lin Faquan , Bao Wei , Zhang Yangyang , Liu Yi , Li Xiaohui , Hou Wei , Zeng Qiyan 
Published: June 2023

AbstractBackgroundAltered expressions of genes in immune cells and synovial tissues are involved in the pathology of rheumatoid arthritis (RA). Long noncoding RNAs act as competing endogenous RNAs and can cause immune disorders. The goal of this study was to reveal the association between noncoding RNA linc00324 and RA, and a plausible action mechanism was proposed.MethodsRT‐qPCR was used to evaluate the expression of linc00324 in peripheral blood mononuclear cells isolated from 50 RA patients and 50 healthy controls, and the correlations between linc00324 level and the clinical indicators were analyzed. Flow cytometry was used to characterize CD4+ T cells. The effects of linc00324 on cytokine production and cell proliferation of CD4+ T cells were evaluated by ELISA assay and Western blot. The interaction between linc00324 and miR‐10a‐5p was investigated by RNA immunoprecipitation and dual‐luciferase assays.ResultsThe linc00324 expression was significantly enhanced in RA patients, and linc00324 expression was positively correlated with rheumatoid factor and CD4+ T cells. Overexpression of linc00324 promoted CD4+ T cells proliferation, and enhanced chemokine MIP‐1α secretion and NF‐κB phosphorylation level, whereas knockout of linc00324 blocked CD4+ T cell proliferation and NF‐κB phosphorylation. Overexpression of miR‐10a‐5p led to the decrease of CD4+ T cells proliferation and NF‐κB phosphorylation, and reversed the effects of linc00324 on cell proliferation and NF‐κB activity.ConclusionLinc00324 was upregulated in RA and may exaggerate inflammation by targeting miR‐10a‐5p through NF‐κB signaling pathway.
The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had an immunological failure
Authors: Mortezazadeh Masoud , Kalantari Saeed , Abolghasemi Nooshin , Ranjbar Mitra , Ebrahimi Saeedeh , Mofidi Abbas , Pezeshkpour Babak , Mansouri Ensieh Sadat , Tabatabaei Seyed Zia , Kashani Mehdi 
Published: June 2023

AbstractIntroductionProbiotics are live microorganisms that, when administered in appropriate colonies, can delay the destruction of the immune system and contribute to the maintenance of immunity in HIV patients. Probiotics play an important role in stimulating natural killer T cells, strengthening the functional gut barrier, and reducing systemic inflammation.MethodsThis study was a randomized double‐blind clinical trial involving 30 patients treated with antiretroviral therapy who had experienced immunological failure despite HIV viral suppression. Patients were divided into two equal groups of 15, group (B) received two probiotic capsules daily with a colony count of 10⁹ CFU per capsule containing seven strains, after 3 months they were examined for CD4+ counts by flow cytometry, and after a 1‐month washout period the participants who had received probiotics were switched to placebo, and the participants who had received placebo were given probiotics for 3 months, and they were examined for CD4+ counts 7 months after the start of the study.ResultsIn the first group (A), administration of the placebo resulted in a decrease in CD4 count in the first 3 months (from 202.21 to 181.79, p value < .001), which may be due to the natural history of the disease. After probiotics administration, CD4 count increased significantly (from 181.79 to 243.86, p value < .001). Overall, after 7 months of study, there was a significant increase in the mean CD count from 202.21 to 243.86 (p value < .001). In the second group (B), the administration of probiotics in the first 3 months of the study resulted in a significant increase in the mean CD4 count (from 126.45 to 175.73, p value < .001). Termination of treatment with probiotics resulted in a significant decrease (from 175.73 to 138.9, p value < .001) but overall the CD4 count at the end of the study was significantly higher than at baseline (p value < .001).
Prevalence and complication of COVID‐19 in patients with ankylosing spondylitis (AS) and its relationship with TNF‐a inhibitors
Authors: Movassaghi Shafieh , SeyedAlinaghi SeyedAhmad , Rostamian Abdolrahman , Najafizadeh Seyed Reza , Nezhadseifi Elham 
Published: June 2023

AbstractIntroductionAnkylosing spondylitis (AS) is a condition that is treated with nonsteroidal anti‐inflammatory drugs and biological drugs such as anti tumor necrosis factor alpha (TNF‐α). This study examined the prevalence of COVID‐19 among individuals with AS and compare it between those receiving and not receiving TNF‐α inhibitors.MethodsA cross‐sectional study was conducted at the rheumatology clinic of Imam Khomeini Hospital in Tehran, Iran. The study included patients with AS who sought treatment at the clinic. Demographic information, laboratory and radiographic findings, and disease activity were recorded through interviews and examinations using a questionnaire.ResultsA total of 40 patients were studied over the course of 1 year. Among them, 31 patients were administered anti‐TNF‐α drugs, with 15 patients (48.3%) receiving subcutaneous Altebrel (Etanercept), 3 patients (9.6%) receiving intravenous Infliximab, and 13 patients (41.9%) receiving subcutaneous Cinnora (Adalimumab). Of the total, 7 patients (17.5%) tested positive for COVID‐19, 1 of whom was confirmed through both CT scan and polymerase chain reaction (PCR) testing, while the remaining 6 patients were confirmed only through PCR testing. All patients tested positive for COVID‐19 were male, and 6 of them had received Altebrel. Among the 9 AS patients who did not receive TNF inhibitors, 1 patient contracted SARS‐CoV‐2. The clinical symptoms experienced by these patients were mild, and hospitalization was not required. However, 1 patient who had insulin‐dependent type 1 diabetes and was receiving Infliximab required hospitalization. This patient exhibited more severe COVID‐19 symptoms, including high fever, pulmonary involvement, dyspnea, and decreased oxygen saturation. No cases of COVID‐19 were reported in the Cinnora treatment group. The use of any of the drugs did not demonstrate a significant relationship with the occurrence of COVID‐19 in patients.ConclusionsThe use of the TNF‐α inhibitors in patients with AS, may be associated with reduced hospitalization and death rate in COVID‐19 cases.
The trichotomy of HER2 expression confers new insights into the understanding and managing for breast cancer stratified by HER2 status
Authors: Jiang Mingxia , Liu Jiaxuan , Li Qiao , Xu Binghe 
Published: June 2023

AbstractHuman epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor that plays a carcinogenic role in breast cancer (BC) through gene amplification, mutation, or overexpression. Traditional methods of HER2 detection were divided into positive (immunohistochemistry (IHC) 3+/fluorescence in situ hybridization (FISH) amplification) and negative (IHC 2+/FISH−, IHC 1+, IHC 0) according to the dichotomy method. Anti‐HER2‐targeted therapies, such as trastuzumab and pertuzumab, have significantly improved the prognosis of HER2‐positive patients. However, up to 75% to 85% of patients remain HER2‐negative. In recent years, with the rapid development of molecular biology, gene detection technology, targeted therapy, and immunotherapy, researchers have actively explored the clinicopathological characteristics, molecular biological characteristics, treatment methods, and HER2 detection methods of HER2‐low/zero breast cancer. With the clinical efficacy of new anti‐HER2 targeted drugs, accurate classification of breast cancer is very important for the treatment choice. Therefore, the following review summarizes the necessity of developing HER2 detection methods, and the clinicopathological and drug treatment characteristics of patients with HER2‐low/zero, to light the dawn of the treatment of breast cancer patients with HER2‐low/zero expression.
Time moving or ego moving? How time metaphors influence perceived temporal distance
Authors: Xu Xiaobing , Jia Miaolei , Chen Rong 
Published: June 2023

AbstractConsumers often use spatial metaphors to describe time. Through six studies, the present research demonstrates that time metaphors influence consumers' perceptions of the temporal distance to future events. Specifically, an ego‐moving metaphor, which characterizes the movement of the self across a timeline from present to future, leads consumers to perceive a target event as more temporally distant than a time‐moving metaphor that illustrates the movement of the event from future to present. This time metaphor distance effect arises because the ego‐moving (vs. time‐moving) metaphor hinders psychological arousal and thus makes the events seem more temporally distant. We also demonstrate a downstream consequence of this effect: by lengthening the perceived temporal distance, the ego‐moving (vs. time‐moving) metaphor leads to greater consumer impatience in a waiting context.