bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Geometry-Driven Neural Topic Model for Trip Purpose Inference
Authors: Zhang Jiaqi , Fan Zipei , Song Xuan , Shibasaki Ryosuke 
Published: May 2023

Abstract
Understanding urban human mobility, particularly trip purposes, is essential for optimizing traffic management, personalized recommendations, and urban planning. However, in real-world scenarios, trip purposes cannot be directly extracted from trajectory data. To address this issue, we propose a geometry-driven neural topic model for trip purpose inference. We integrate trajectory data with nearby points of interest (POI) data using a geometry-driven technique to enhance the interpretability of the results. Furthermore, our model captures the semantics and relationships of the data in a high-dimensional space and identifies latent topics representing distinct trip purposes. These learned topics are analyzed using clustering algorithms to group similar trips, enabling trip purpose inference. And we evaluate our model using the trajectory data of Shenzhen and Chengdu, and compare it with baseline models. The results demonstrate that our model performs well. Furthermore, we analyze trajectory data containing trip purpose information to gain insights into human mobility patterns and the influence of trip purposes, paving the way for potential implications and future research directions.
Research on the evolutionary game of civil aviation dangerous goods transportation training supervision new path
Authors: shen haibin , zhao shengnan , jia xiaonan , wang yueyi 
Published: May 2023

Abstract
This study is carried out to promote the accurate supervision of dangerous goods transportation training and ensure the stable development of dangerous goods transportation training market. First, from the actual situation of civil aviation dangerous goods transportation training supervision, the feasibility of the trainees' subordinate units as the new path of external supervision or trainees as the new path of internal supervision are considered. Then, based on the evolutionary game theory, this study constructs an evolutionary game model of civil aviation dangerous goods transportation training supervision under the participation of the trainees' subordinate units or trainees, and analyzes the influence of new subjects' participation on the behavior strategy selection of dangerous goods transportation training institutions, the Civil Aviation Administration of China (CAAC). The conclusions reveal that in the regulatory relationship of civil aviation dangerous goods transportation training, the participation of the trainees' subordinate units or trainees can improve the supervisory efficiency, curb the non-compliant training behavior, urge the CAAC to carry out the supervision work with due diligence, and further ensure the safety of air transportation. The higher the willingness of the trainees' subordinate units or trainees to participate, the better the effect.
Variation of Atomic Radii as a Function of Pressure: A Theoretical Study
Authors: Kumari Dimple , Tandon Hiteshi , Chakraborty Tanmoy 
Published: May 2023

Abstract
In the presence of pressure, interesting chemical events can happen, including the synthesis of unexpected compounds and the development of abnormal crystal structures. Often, these events have no logical explanation, and there are no chemical laws or models that can predict them. Research is active in the genesis of chemical events under pressure. Significance of the size of an atom and atomic electronegativity in determining the nature of the chemical reactivity of a species is well known. In this work, we have explored the inverse relationship between electronegativity and radius to compute a set of atomic radii as a function of pressure. In terms of computation of internuclear bond distances of some molecules, the reliability of the newly proposed scale is further analyzed. The results corroborate the experimental trend and justify the significance of pressure in reference to chemical phenomena.
Exploring unimolecular reactions in disilanol and ethanol: Insights and challenges
Authors: Vázquez Saulo A , Martínez-Núñez Emilio , Preston Thomas J 
Published: May 2023

Abstract
Unimolecular reactions of small silicon oxyhydrides constitute a subset of the full reaction networks that lead to larger species. Previous methods for mechanism discovery have largely been done by manual exploration using chemical intuition. Those works have established general concepts for silanol, SiOH4. The present work is a first attempt to use the automated mechanism discovery of the program AutoMeKin to elucidate the unimolecular reactions of disilanol, Si2OH6. We find that the semi-empirical surfaces used for preliminary exploration insufficiently describe silicon chemistry. As a workaround, we implement an intermediate optimization step to temper these shortcomings. The method recovers the known mechanisms in SiOH4 and C2OH6, which we use for validation. Key results for Si2OH6 include descriptions of relevant elementary reactions, the reaction network, and comparisons with better-known hydrocarbon and silicon hydride reactions. Although the current method shows promise, some shortcomings arise. We discuss the reliability of the generated reaction network and address approaches for further mechanistic understanding of silicon chemistry for material synthesis.
Dietary risk of donated food at an Australian food bank: an audit protocol
Authors: Mossenson Sharonna , Giglia Roslyn , Pulker Claire E , Chester Miranda , Pollard Christina M 
Published: May 2023

Abstract
Background Sufficient, safe and nutritious food is unattainable for many people experiencing severe food insecurity, putting them at dietary risk. Food banks, a growing part of the charitable food system (CFS), are the main source of food relief in developed countries. Donations of surplus, unsalable food from supermarkets, producers and manufacturers is the main source of the food supply, and this can be unpredictable, insufficient and inappropriate. The universal performance indicator of food-banking success is a weight-based measure, complemented by various initiatives to track the nutritional quality of food provided. There is currently no method that assesses the dietary risk of donated food related to nutrition and food safety. This protocol describes a method developed to identify and assess the dietary risk of donated food at an Australian food bank including the type, amount, nutrition quality, and food safety.Methods An audit of all food donated to a food bank servicing one Australian state was conducted over five consecutive days in May 2022. The audit process used a mobile device to take photographs of all incoming deliveries to the food bank. The images were manually annotated to document the type of food, product information (brand and product name, variety), the donor’s name, weight (kilograms), and date-marking details. Data was extracted from the photographs and assessed against pre-determined dietary risk criterion for food safety (date marking, damaged packaging, visible food spoilage) and nutrition quality according to the principles of the Australian Guide to Healthy Eating, and the NOVA classification of level of processing.Discussion Fifteen hundred images were required to assess the dietary risk of 86,050kg of donated food. There were 1222 food products from 72 separate donations, largely from supermarkets and food manufacturers. Data analysis will enable identification of dietary risk, particularly for nutrition quality and food safety. This is important given the absence of food regulation for CFS donations, and the vulnerability of the client group. This protocol highlights the need for more transparency and accountability from food donors, about the food they donate.
Measurements in a turbulent channel flow bymeans of an LDV profile sensor
Authors: Pasch Saskia , Leister Robin , Gatti Davide , Örlü Ramis , Frohnapfel Bettina , Kriegseis Jochen 
Published: May 2023

Abstract
For the development of flow control techniques in wall-bounded turbulent flows, precise measurements of the flow in the proximity of the wall are essential. A laser Doppler velocity profile-sensor (LDV-PS) allows the combined measurement of tracer particle positions and velocities, which makes it a promising tool for flow measurements with high spatial resolution in flows with high velocity gradients. Therefore, the LDV-PS is employed in measurements of a turbulent channel flow at Reτ = 350. Additionally, LDV-PS measurement and signal-processing accuracies of velocity and location estimations are evaluated for various tracer-object sizes and velocities. On this basis, the turbulent channel flow measurements are evaluated and compared to reference data from direct numerical simulations. Thus, potentials of the LDV-PS are investigated for different regions of the flow, and various data processing routines as well as the experimental practice are discussed from an application perspective.
Complexation of water-soluble phosphorylated calixarenes with uracils. Stability constants and DFT study of the supramolecular complexes
Authors: Kalchenko O. I. , Rozhenko A. B. , Cherenok S. O. , Selikhova A. I. , Suikov S. Yu. , Kyrylchuk A. А. , Kalchenko V. I. 
Published: May 2023

Abstract
Modification of the upper rim of the lipophilic cone-shaped tetrapropoxycalix[4]arene with hydrophilic phosphine oxide groups or phosphinic acid groups yielded nano-sized water-soluble calixarenes that form supramolecular complexes with uracils, including active pharmaceutical ingredients of 5-Fluorouracil and 5-Methyluracil drugs. Stability constants of the formed complexes in an aqueous-organic medium were determined by the HPLC method. The most favored structures of the calixarenes and their uracil complexes were optimized at the DFT level of approximation. In in the most favored structures of all adducts, the uracil molecules coordinate via hydrogen bonding with the phosphorus-containing groups on the upper rim of the calixarene ligands.
Pilot clinical trial and phenotypic analysis in chemotherapy-pretreated, metastatic triple-negative breast cancer patients treated with oral TAK-228 and TAK-117 (PIKTOR) to increase DNA damage repair deficiency followed by cisplatin and nab paclitaxel
Authors: Lang Jessica D. , Nguyen Tuong Vi V. , Levin Maren K. , Blas Page E. , Williams Heather L. , Rodriguez Esther San Roman , Briones Natalia , Mueller Claudius , Selleck William , Moore Sarah , Zismann Victoria L. , Hendricks William P. D. , Espina Virginia , O'Shaughnessy Joyce 
Published: May 2023

Abstract
BACKGROUND A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-117 (PI3Kα inhibitor), is hypothesized to increase genomic instability and increase DNA damage repair (DDR) deficiency, leading to increased sensitivity to DNA-damaging chemotherapy and to immune checkpoint blockade inhibitors.METHODS 10 metastatic TNBC patients received 4mg TAK-228 and 200mg TAK-117 (PIKTOR) orally each day for 3 days followed by 4 days off, weekly, until disease progression (PD), followed by intravenous cisplatin 75 mg/m2 plus nab paclitaxel 220 mg/m2 every 3 weeks for up to 6 cycles. Patients received subsequent treatment with pembrolizumab and/or chemotherapy. Primary endpoints were objective response rate with cisplatin/nab paclitaxel and safety. Biopsies of a metastatic lesion were collected prior to and at PD on PIKTOR. Whole exome and RNA-sequencing and reverse phase protein arrays (RPPA) were used to phenotype tumors pre- and post-PIKTOR for alterations in DDR, proliferation, and immune response.RESULTS With cisplatin/nab paclitaxel (cis/nab pac) therapy post PIKTOR, 3 patients had clinical benefit (1 partial response (PR) and 2 stable disease (SD) ≥ 6 months) and continued to have durable benefit in progression-free survival with pembrolizumab post-cis/nab pac for 1.2, 2, and 3.6 years. Their post-PIKTOR metastatic tissue displayed decreased mismatch repair (MMR), increased tumor mutation burden, and significantly lower levels of 53BP1, DAG Lipase β, GCN2, AKT Ser473, and PKCzeta Thr410/403 compared to pre-PIKTOR tumor tissue.CONCLUSIONS Priming patients’ chemotherapy-pretreated metastatic TNBC with PIKTOR led to very prolonged response/disease control with subsequent cis/nab pac, followed by pembrolizumab, in 3 of 10 treated patients. Our multi-omics approach revealed a higher number of genomic alterations, reductions in MMR, and alterations in immune and stress response pathways post-PIKTOR in patients who had durable responses.TRIAL REGISTRATION This clinical trial was registered on June 21, 2017, at ClinicalTrials.gov using identifier NCT03193853.
Fixed point theorems on B4 - metric space
Authors: Srinivasa Ch. , Kumar S. Ravi , Sarma K. K.M. 
Published: May 2023

Abstract
Recently, B4-metric spaces are introduced as a generalization of metric spaces. In this paper, we introduce new contractive mappings on B4-metric spaces and investigate relationships among them. Examples and counterexamples are provided as and when necessary. In addition, we obtain fixed point theorems for self-maps on B4-metric spaces.
AMS(2010) Mathematics Subject Classification: 47H10, 54H25.
Dissolved organic carbon fluxes to oceans under climate change
Authors: Fabre Clément , Sauvage Sabine , Vliet Michelle T.H. van , Pastor Amandine V. , Sánchez-Pérez José-Miguel 
Published: May 2023

Abstract
Climate change is a primary concern in the coming decades and affects temporal and spatial patterns in temperature and hydrology worldwide. These variations will undoubtedly affect the global carbon balance. The export of riverine dissolved organic carbon (DOC) to oceans is crucial in the carbon balance and oceanic food web maintenance. Recent modelling quantified current daily DOC exports and future daily discharges delivered to the oceans. We intend to quantify future daily DOC deliveries from large rivers with a generic model integrating future temperature and hydrological dynamics under changing climate. On a set of 308 large rivers, we found significant increases in global DOC exports to the oceans of + 5.9% ± 0.1% for RCP 2.6 and + 14.6% ± 0.1% for RCP 8.5. Among all watersheds, Arctic catchments returned the largest rises of + 19.1% ± 0.4% for RCP 2.6 and of + 38.0% ± 0.1% for RCP 8.5. It highlights the high variability in future DOC deliveries, affecting future carbon transport to the oceans, especially in Arctic areas. These increases might affect the local and global sustainability of aquatic ecosystems.
Has retail competition reduced residential electricity prices in Texas?
Authors: Zarnikau J. , Cao K. H. , Qi H. S. , Woo C. K. 
Published: May 2023

AbstractA review of 19 extant studies reveals mixed effects of retail competition effect on retail electricity prices in various jurisdictions in the United States. This conflicting evidence is largely due to the differences in these studies’ market locations, pre-competition conditions, data types, estimation methods and features of the restructuring plan. Contributing to the debate on the impacts of electricity market reform on retail prices, we estimate the impact from the introduction of retail competition on retail electricity prices paid by residential consumers in Texas in two cities opened to retail competition. We find that retail competition raised average prices by $0.0112/kWh ($11.2/MWh) in the transition period from 2001 to 2006 and by $0.0134/kWh ($13.4/MWh) during the period of unfettered competition from 2007 to 2020. However, when the US wholesale natural gas prices are relatively low, actual retail electricity prices in areas opened to retail competition are close to the prices that would have prevailed had retail competition not been introduced, as measured by the counterfactual prices estimated using the synthetic control method.JEL Codes: L51, L94, Z18, Q48
Association between heavy metal uptake and growth and reproduction in the anecic earthworm, Alma nilotica
Authors: Fai Patricia Bi Asanga , Ngogang Josephine Ngoune , Djeukam Mariette Kouemo , Nfor Brian , Fobil Julius N. , Basu Niladri 
Published: May 2023

Abstract

Elevated heavy metal concentrations in soils is a cause for concern as they are hazardous to soil organisms including earthworms which are considered as ecosystem engineers. Current ecotoxicity tests predominantly use temperate earthworm species, and thus there is the need to include a broader genera of native species to improve ecological risk assessment. Alma nilotica, is a tropical anecic earthworm species that survives well under laboratory conditions and has potential for use in ecotoxicology testing but lacks published toxicity data for important pollutants. Growth and reproduction bioassays were carried out with Alma nilotica to determine the relationship between the concentrations of Cu, Zn, Pb and Cr in spiked soils and their bioaccumulation and toxic effects. Positive linear relationships were found between soil-metal and internal earthworm-metal concentrations. Cu did not inhibit growth up to 35 days of exposure but became toxic with longer exposure duration. Zn was not regulated by Alma nilotica although it is an essential metal that is well regulated by Eisenia sp. commonly used in standard ecotoxicity tests, showing differences in metal regulation by earthworms of different ecological functional groups. Based on bioaccumulation factors (BAFs), growth inhibition and reproduction effects the metals were ranked in decreasing toxicity as Pb > Cr > Zn > Cu. The mean 20% Internal Effects Concentrations (IEC20s) for reproduction were 1.03. 1.77, 10.2 and 218 mg metal/kg earthworm for Pb, Cr, Zn and Cu respectively. These data can contribute to the improvement of metal risk assessment particularly in tropical contexts.
Adequate iodine nutrition and higher salt intake in Chinese adults compared with WHO recommendations
Authors: Qun Diqun Di , Ye Ying , Lan Ying , He Meng , Wu Jiani , Wang Lijin , Chen Zhihui 
Published: May 2023

Abstract
Objective: Iodine deficiency and excessive salt intake have adverse health effects. This study evaluated the iodine level and salt intake in Chinese adults after implementing the salt reduction program and compared both with the World Health Organization (WHO) recommendations.
Methods：Adults aged 18–59 years were randomly selected using multi-stage stratified random sampling in Fujian Province, China. Iodine, sodium, and creatinine concentrations in spot urine samples were measured. Knudsen equation was used to determine 24-h urinary iodine and sodium excretion.
Results: The median urinary iodine concentration (mUIC) among adults (n = 3513) was 132.0 μg/L. No significant differences were observed in mUIC between sexes and age groups (P > 0.05). The median daily salt intake (DSI) among Chinese adults was 10.2 g/d, and only <13.6% of the population met the recommended WHO upper DSI level of 5 g/d. The DSI of residents was higher in the noncoastal rural areas than in the other three areas (P < 0.05). The adults aged 45–59 years consumed more salt compared with those aged 18–49 years (P < 0.05). The logistic regression demonstrated that the people living in coastal and noncoastal urban areas consumed less salt compared with those in noncoastal rural areas. Except for noncoastal urban areas, the daily iodine intake was lower (<150 μg/d) among women of childbearing age in the low–salt intake group (<5 g/d) (P < 0.05) compared with the high–salt intake group (≥5 g/d).
Conclusions：Iodine nutrition in Chinese adults was sufficient, but the salt intake was substantially higher than the WHO recommendations. Further policy implementation is needed to reduce salt intake and improve the monitoring of iodine levels in Chinese adults, especially in women of childbearing age.
Multi-dimensional insight into the coexistence of pathogenic genes for ADAR1 and TSC2: careful consideration is essential for interpretation of ADAR1 variants
Authors: Liu Xiangyu , Lei Meifang , Xue Yan , Li Hong , Yin Jing , Li Dong , Shu Jianbo , Cai Chunquan 
Published: May 2023

Abstract
Background
Aicardi-Goutières syndrome 6 (AGS6) is a serious auto immunization-associated acute neurologic decompensation. AGS6 manifests as acute onset of severe generalized dystonia of limbs and developmental regression secondary to febrile illness mostly. Dyschromatosis symmetrica hereditaria (DSH), as pigmentary genodermatosis, is characterized mixture of hyperpigmented and hypopigmented macules. Both AGS6 and DSH are associated with ADAR1 pathogenic variants.
Methods
To explore the etiology of a proband with developmental regression with mixture of hyperpigmentation and hypopigmentation macules, we used the trio-WES. Later, to clarify the association between variants and diseases, we used guidelines of ACMG for variants interpretation and quantitative Real-time PCR for verifying elevated expression levels of interferon-stimulated genes, separately.
Results
By WES, we detected 2 variants in ADAR1 and a variant in TSC2, respectively were NM_001111.5: c.1096_1097del, NM_001111.5: c.518A>G, and NM_000548.5: c.1864C>T. Variants interpretation suggested that these 3 variants were both pathogenic. Expression levels of interferon-stimulated genes also elevated as expected.
Conclusion
We verified the co-occurrence of pathogenic variants of ADAR1 and TSC2 in AGS6 patients with DSH. Our works contributed to the elucidation of ADAR1 pathogenic mechanism, given the specific pathogenic mechanism of ADAR1, it is necessary to consider with caution when variants were found in ADAR1.
On intrinsic susceptibility of healthy organs to primary cancer or metastasis
Authors: Trajkovic Katarina , Gelemanovic Andrea , Vidovic Tinka , Radman Miroslav 
Published: May 2023

Abstract
Although primary cancer can affect any part of the body, there is a striking variability in cancer prevalence across different organs. Moreover, metastases are non-randomly distributed among organs, with lung, liver, lymph nodes and bone acting as metastatic hotspots. The reasons for such inter-organ variability in the prevalence of primary cancers and metastases are insufficiently understood. In this in silico study we show that susceptibility of organs to a primary cancer or a metastasis is linked with their distinctive intrinsic features in the healthy state. In particular, while susceptibility of an organ to primary cancer is associated with the abundance of arterial endothelial cells and atypical gene expression, susceptibility to metastases correlates with high content of immune cells and high expression of immune genes. These data shed light on some fundamental aspects of cancer biology and pave new avenues for mitigation of cancer.