bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare resource use and associated costs for patients with an ileostomy experiencing peristomal skin complications
Authors: Rolls N. , de Fries Jensen L. , Mthombeni F. , Vardanega V. , Håkan‐Bloch J. , van Hest N. , Karlsmark T. 
Published: April 2023

AbstractPeristomal skin complications (PSCs) have a significant impact on quality of life and ostomy treatment costs. This study aimed to assess the healthcare resource use for patients with an ileostomy and PSCs symptoms. Two surveys were developed and, after validation by healthcare professionals and patients, data were collected on healthcare resource use while not experiencing any PSCs symptoms and while experiencing complications of various severities, as defined by the modified Ostomy Skin Tool. Costs applied to resource use were assigned from relevant United Kingdom sources. Additional healthcare resource use associated with PSCs, relative to no complications, was estimated to result in a total cost per instance of £258, £383, and £505 for mild, moderate, or severe PSC, respectively. The average estimated total cost per complication instance, weighted across mild, moderate, and severe PSCs, was £349. Severe‐level PSCs were associated with the highest cost, because of the treatment‐level required and the longer duration of symptoms. There is potential for clinical benefits and economising in stoma care if interventions are implemented that reduce the incidence and/or severity of PSCs.
Recent insights into the networking of CLN genes and proteins in mammalian cells
Authors: Huber Robert J. 
Published: April 2023

AbstractCeroid lipofuscinosis neuronal (CLN) genes encode 13 proteins that localize throughout the endomembrane system to regulate a variety of cellular processes. In humans, mutations in CLN genes cause a devastating form of neurodegeneration called neuronal ceroid lipofuscinosis (NCL), commonly known as Batten disease. Each CLN gene is associated with a specific subtype of the disease that differ from each other in severity and age of onset. The NCLs affect all ages and ethnicities worldwide but primarily affect children. The pathology underlying the NCLs is poorly understood, which has prevented the development of a cure or effective therapy for most subtypes of the disease. A growing body of literature supports the networking of CLN genes and proteins within cells, which aligns with the broadly similar cellular and clinical manifestations among the different subtypes of NCL. Here, all relevant literature is reviewed to provide a comprehensive overview of our current understanding of how CLN genes and proteins are networked in mammalian cells with an aim toward revealing new molecular targets for therapy development. Intriguingly, CLN gene and protein networking extends beyond the NCLs as recent work has linked several CLN genes and proteins to other forms of neurodegeneration such as Alzheimer's disease and Parkinson's disease. Thus, a deeper understanding of the pathways and cellular processes impacted by mutations in CLN genes will not only strengthen our knowledge of the pathological mechanisms underlying the NCLs but may also provide new insight into related forms of neurodegeneration.image
Prevalence of temporomandibular disorders (TMD) in pregnancy: A systematic review with meta‐analysis
Authors: Minervini Giuseppe , Franco Rocco , Marrapodi Maria Maddalena , Fiorillo Luca , Cervino Gabriele , Cicciù Marco 
Published: April 2023

AbstractBackgroundOver the past few years, researchers have investigated whether varying menstrual statuses and oestrogen levels could affect the likelihood of temporomandibular disorders (TMDs), with conflicting results. While some studies suggest a potential link between increased oestrogen levels and higher TMD risk, others have found no correlation. It is worth noting that oestrogen levels can impact the structure and function of the temporomandibular joint (TMJ). In the light of these findings, our study seeks to investigate the prevalence of TMDs among pregnant women.MethodsWe searched in PubMed, Web of Science and Lilacs for articles published from the inception until 20 January 2023. We applied the Population, Exposure, Comparator and Outcomes (PECO) model to assess the document eligibility: (P) Participants: female human subjects. (E) Exposure: pregnancy. (C) Comparison: pregnant women compared to non‐pregnant women in the childbearing age. (O) Outcome: TMDs diagnosis. Only study providing data about the prevalence in both group (pregnant and non‐pregnant) were included. We set the following exclusion criteria: (1) diagnosis of rheumatic diseases or chronic inflammatory disorders (e.g. rheumatoid arthritis, juvenile, idiopathic arthritis, psoriatic arthritis); (2) diagnosis of fibromyalgia; (3) congenital abnormality or neoplastic conditions in the TMJ region; (4) studies including subjects undergoing arthrocentesis or intra‐articular infiltrations; (5) studies including local pressure pain assessment; (6) studies including women in menopause in the control group (7) cross‐over study design; (8) language different from English; (9) full‐ text unavailability (i.e. posters and conference abstracts); (10) studies involving animals; (11) review (topical or systematic) article; (12) case reports/series; (13) studies evaluating TMDs prevalence in subjects not pregnant. The software Review Manager version 5.2.8 (Cochrane Collaboration) was used to perform the pooled analysis. We measured the risk ratio (RR) between the two groups (pregnant and non‐pregnant).ResultsThe included subjects in this review were 440. Among them, 244 were pregnant while the remaining 196 were age matched non‐pregnant women. Among those pregnant 102 presented sign/symptoms of TMD or TMD diagnosis (41.8%) whereas 80 of those not pregnant were diagnosed with (40.8%). The overall effect showed that there was no difference in TMD prevalence between pregnant and non‐pregnant women in childbearing age (RR 1.12; 95% CI: 0.65–1.93), suggesting that pregnant is neither a risk factor nor a protective factor for TMD.ConclusionsOverall, we did not find an association between TMD and pregnancy, neither positive nor negative. Further studies on larger samples are needed to clarify our results.
Caffeine consumption and sleep in a submarine environment: An observational study
Authors: Chabal Sarah , Folstein Jonathan R. , Chinoy Evan D. , Markwald Rachel R. , Lieberman Harris R. 
Published: April 2023

SummarySubmariners face many environmental and operational challenges to maintaining good sleep, including suboptimal lighting, shift work, and frequent interruptions. Anecdotally, many Sailors consume caffeine to alleviate the effects of poor sleep on alertness, mood, and performance; however, caffeine itself may also degrade sleep quantity and/or quality. This study provides the first exploration of the potential relationship between caffeine use and sleep onboard submarines. Objective measures (wrist actigraphy, available from 45 participants), self‐report sleep metrics, and self‐reported caffeine consumption were collected from 58 US Navy Sailors before and during a routine submarine underway at sea lasting 30 days. Contrary to expectations, less caffeine was reportedly consumed at sea (232.8 ± 241.1 mg) than on land prior to the underway (M = 284.4 ± 251.7 mg; X2(1) = 7.43, p = 0.006), positive rather than negative relationships were observed between caffeine consumption and sleep efficiency (F = 6.11, p = 0.02), and negative relationships were observed between caffeine consumption and wake after sleep onset (F = 9.36, p = 0.004) and sleep fragmentation (F = 24.73, p < 0.0001). However, in contrast, higher caffeine consumption was also negatively related to self‐reported sleep duration while at sea (F = 4.73, p = 0.03). This observational study is the first to measure relationships between caffeine consumption and sleep quantity and/or quality in a submarine environment. We propose that the unique submarine environment and the unique caffeine consumption patterns of submariners should be considered in the development of potential countermeasures for sleepiness.
Why patent waiver for Covid‐19 vaccines and pharmaceuticals?
Authors: Kumar Mrityunjay , Bharti Nalin 
Published: April 2023

AbstractPatent protection emerged as one of the most challenging barriers to the access to medicines, medical equipment, and vaccines as well for the treatment and containment of Covid‐19 when it became a pandemic. The severe scarcity of vaccines and pharmaceutical products were weakening the fight against Covid‐19, and endeavor to contain the recurrence of pandemic waves while mutation of the SARS‐CoV‐2 was also on the full swing. Therefore, India and South Africa jointly proposed for patent waiver at WTO in October 2020 to effectively deal with the short‐supply of medicines, medical equipment, vaccines and high price concern related to these products. After 20 months of consultation and negotiations with major stakeholders, the WTO came up with decision on patent waiver in 12th Ministerial Conference (12th MC). The time taken to reach to the decision in the pandemic situation and the narrow scope of the decision is a serious concern for the entire world to deal effectively with Covid‐19 and its variants. This paper attempts to analyse the patent waiver in the context of the agreement on Trade Related Aspects of Intellectual Property Rights (TRIPS). It discusses patent barriers, alternative measures and needs for equitable access to vaccines and pharmaceuticals amidst the pandemic. Paper applies the qualitative methodology of research mainly content analysis method in the framework of contextualisation, decontextualisation, and recontextualisation. Results show that suspending certain provisions of the TRIPS required for the production of vaccines and medicines would prove a crucial tool for economies to return to its pre‐Covid‐19 era. Paper concludes that, patent waiver can be one of the most important tool to fight the Covid‐19 (as WHO has not yet declared the end of pandemic) and will pave the way to deal with any such unknown future pandemic effectively.
Nowcasting Daily Population Displacement in Ukraine through Social Media Advertising Data
Authors: Leasure Douglas R. , Kashyap Ridhi , Rampazzo Francesco , Dooley Claire A. , Elbers Benjamin , Bondarenko Maksym , Verhagen Mark , Frey Arun , Yan Jiani , Akimova Evelina T. , Fatehkia Masoomali , Trigwell Robert , Tatem Andrew J. , Weber Ingmar , Mills Melinda C. 
Published: April 2023

AbstractIn times of crisis, real‐time data mapping population displacements are invaluable for targeted humanitarian response. The Russian invasion of Ukraine on February 24, 2022, forcibly displaced millions of people from their homes including nearly 6 million refugees flowing across the border in just a few weeks, but information was scarce regarding displaced and vulnerable populations who remained inside Ukraine. We leveraged social media data from Facebook's advertising platform in combination with preconflict population data to build a real‐time monitoring system to estimate subnational population sizes every day disaggregated by age and sex. Using this approach, we estimated that 5.3 million people had been internally displaced away from their baseline administrative region in the first three weeks after the start of the conflict. Results revealed four distinct displacement patterns: large‐scale evacuations, refugee staging areas, internal areas of refuge, and irregular dynamics. While the use of social media provided one of the only quantitative estimates of internal displacement in the conflict setting in virtual real time, we conclude by acknowledging risks and challenges of these new data streams for the future.
Auxin participates in regulating the leaf curl development of Wucai (Brassica campestris L.)
Authors: Hou Jinfeng , Xu Ying , Zhang Shengnan , Yang Xiaona , Wang Shuangshuang , Hong Jie , Dong Cuina , Zhang Ping , Yuan Lingyun , Zhu Shidong , Chen Guohu , Tang Xiaoyan , Huang Xingxue , Zhang Jinlong , Wang Chenggang 
Published: April 2023

AbstractWucai (Brassica campestris L. ssp. chinensis var. rosularis Tsen) belongs to the Brassica genus of the Cruciferae family, and its leaf curl is a typical feature that distinguishes Wucai from other nonheading cabbage subspecies. Our previous research found that plant hormones were involved in the development of the leaf curl in Wucai. However, the molecular mechanisms and the hormones regulating the formation of leaf curl in Wucai have not yet been reported. This study aimed to understand the molecular functions related to hormone metabolism during the formation of leaf curl in Wucai. A total of 386 differentially expressed genes (DEGs) were identified by transcriptome sequencing of two different morphological parts of the same leaf of Wucai germplasm W7‐2, and 50 DEGs were found to be related to plant hormones, which were mainly involved in the auxin signal transduction pathway. Then, we measured the content of endogenous hormones in two different forms of the same leaf of Wucai germplasm W7‐2. A total of 17 hormones with differential content were identified, including auxin, cytokinins, jasmonic acids, salicylic acids, and abscisic acid. And we found that treatment with auxin transport inhibitor N‐1‐naphthylphthalamic acid can affect the leaf curl phenotype of Wucai and pak choi (Brassica rapa L. subsp. Chinensis). These results indicated that plant hormones, especially auxin, are involved in developing the leaf curl of Wucai. Our findings provide a potentially valuable reference for future research on the development of leaf curls.
A systematic review of drying in aquatic products
Authors: Zeng Junpeng , Song Yu , Cong Peixu , Cao Yunrui , Xu Jie , Xue Changhu 
Published: April 2023

AbstractDrying is an essential method for the process and storage of aquatic products. With the removal of water, the occurrence of oxidation, hydrolysis and browning reaction also accompanies it. This article reviews the applications of emerging drying methods in aquatic products, emphasising high‐quality drying. In addition, it summarises the effects of the drying process on the quality of aquatic products, including appearance, nutritional components, flavour and microorganisms. Especially, non‐destructively monitoring technologies are introduced and discussed, including near‐infrared spectroscopy, Raman spectroscopy, hyperspectral imaging, low‐field nuclear magnetic resonance and computer vision system, which are applied to detect and predict the quality of aquatic products. A comprehensive review of recent advances in the research of the drying process of aquatic products is presented, and some perspectives are made for future research.
Fate and effects of fish farm organic waste in marine systems: Advances in understanding using biochemical approaches with implications for environmental management
Authors: Elvines Deanna M. , MacLeod Catriona K. , Ross Donald. J. , Hopkins Grant A. , White Camille A. 
Published: April 2023

AbstractParticulate waste from open‐cage fish farms in marine systems can cause organic enrichment of seabed habitats and enter the food web through consumption by wild organisms, with potential for broader ecosystem changes. Effects on biogeochemistry and benthic ecology are reasonably well understood in inshore, sheltered and soft sediment systems. However, food web effects and interactions with epifauna and larger consumers is less well understood, as is the fate of these discharges in more dynamic coastal areas with complex hydrodynamic regimes. Expected expansion of the aquaculture industry globally includes farming new areas that are more environmentally dynamic and biodiverse, with potentially sensitive habitats. Therefore, the aim of this review was to examine how biochemical tools can assist in identifying and managing impacts. Biochemical tools such as bulk stable isotopes and fatty acids can reliably trace the fate of fish waste in the environment and the food web, and have advanced our understanding of waste dispersal, as well as providing greater insights into biological interactions with fish wastes. This includes elucidating trophic subsidies to wild organisms, candidate species for co‐culture and waste assimilation mechanisms in native communities. Ultimately, biochemical tools can support improved environmental management, by helping to identify the zone of influence for spatial planning, providing additional ‘forensic’ evidence for farm‐related change, and by identifying potential risks to high‐value species and habitats. In this way, they can inform targeted research to link fish waste inputs meaningfully to potential ecosystem changes to better understand the consequences to support sustainable industry expansion.
Affected by and affecting forest fires in Sweden and Spain: A critical feminist analysis of vulnerability to fire
Authors: González‐Hidalgo Marien 
Published: April 2023

AbstractUsually, vulnerability is equated to weakness and resistance to strength. Drawing on a feminist critique of this conceptualisation, this article aims to discuss how vulnerability to forest fires and local action are mutually and contradictorily related. I analyse the ways in which people in two rural communities surrounded by tree monocultures in Sweden and Spain think, feel and act after being exposed to acute forest fires in 2018 and 2017, respectively. Attentively listening to the experiences of vulnerability during and after the fire in the two cases helps to explain vulnerability to forest fires as an emotional, care‐related process that opens up contradictory and transformative interconnections between peoples, nature and the state. Also, looking at the two cases together, this article shows how vulnerability to fire is mediated through unequal expectations across Europe's North–South divide. By re‐signifying the implications of vulnerability, disasters such as those analysed here can be seen as facilitators of radical transformations towards new rural futures in Europe's forests.
A Phytophthora infestansRXLR effector AVR8 suppresses plant immunity by targeting a desumoylating isopeptidase DeSI2
Authors: Jiang Rui , He Qin , Song Jingyi , Liu Zeng , Yu Jian , Hu Kefan , Liu Huiming , Mu Yang , Wu Jiahui , Tian Zhendong , Song Botao , Vleeshouwers Vivianne G. A. A. , Xie Conghua , Du Juan 
Published: April 2023

SUMMARYThe potato's most devastating disease is late blight, which is caused by Phytophthora infestans. Whereas various resistance (R) genes are known, most are typically defeated by this fast‐evolving oomycete pathogen. However, the broad‐spectrum and durable R8 is a vital gene resource for potato resistance breeding. To support an educated deployment of R8, we embarked on a study on the corresponding avirulence gene Avr8. We overexpressed Avr8 by transient and stable transformation, and found that Avr8 promotes colonization of P. infestans in Nicotiana benthamiana and potato, respectively. A yeast‐two‐hybrid (Y2H) screen showed that AVR8 interacts with a desumoylating isopeptidase (StDeSI2) of potato. We overexpressed DeSI2 and found that DeSI2 positively regulates resistance to P. infestans, while silencing StDeSI2 downregulated the expression of a set of defense‐related genes. By using a specific proteasome inhibitor, we found that AVR8 destabilized StDeSI2 through the 26S proteasome and attenuated early PTI responses. Altogether, these results indicate that AVR8 manipulates desumoylation, which is a new strategy that adds to the plethora of mechanisms that Phytophthora exploits to modulate host immunity, and StDeSI2 provides a new target for durable resistance breeding against P. infestans in potato.
Experimental Investigation of Control Rod Drops Into Perturbed Fuel Assemblies
Authors: Park Namgyu , Kwon Ohjoon , Yoo Youngik , Kim Taesoon 
Published: April 2023

Abstract
This paper discusses permanent deformation of the fuel assembly of pressurized water reactors that have to satisfy a drop time requirement of the control rod assembly. During a seismic event, the fuel assemblies and the reactor core exhibit transient vibration. When the fuel assemblies collide, they develop impact forces in the spacer grids along the fuel assemblies. If the impact forces on some spacer grids of the fuel assembly exceed an allowable strength, the buckling occurs in the corresponding spacer grids, followed by permanent deformation. The geometry change of the buckled spacer grids leads to the movement of the guide tube positions in the fuel assembly. Therefore the geometry change is associated with the distortion of the control rod drop path. In this study, the permanent deformation of the spacer grids was measured during the impact tests, and the maximum deviation of the guide tube from the original position was investigated. Control rod drop tests were also performed to measure the change in drop time according to the deformation of the fuel assembly. Using actuators in the loop test facility, the authors realized the first and second bending mode shapes of the fuel assembly under the flowing water condition. Based on a series of drop tests, the critical fuel assembly deformation was identified that could lead to a violation of an allowable drop time of the control rod.
The Role of Endwall Shape Optimization in the Design of Supersonic Turbines for Rotating Detonation Engines
Authors: Mushtaq Noraiz , Persico Giacomo , Gaetani Paolo 
Published: April 2023

Abstract
Rotating detonation engines (RDEs) are characterized by a thermodynamic cycle with an efficiency gain up to 15% at medium pressure ratios with respect to systems based on the conventional Joule–Bryton cycle. Multiple turbine designs can be considered, and this article deals with the supersonic inlet configuration. After having reviewed the main design steps of an exemplary RDE supersonic turbine, the article focuses on the considerable effects that endwall losses have on the performance of supersonic-inlet turbines and on the reasons why endwall contouring is strongly recommended for an efficient design. Parametric analyses, carried out by a novel in-house mean-line code validated against computational fluid dynamics (CFD), reveal that endwall friction losses contribute significantly to the overall stage loss. Endwall boundary layers also reduce the effective area, which can be critical for the self-starting capability of the supersonic channel. Therefore, a variable blade height geometry is necessary to extend the design space and guarantee a higher efficiency with respect to a constant-span configuration. The in-house CFD-based evolutionary shape optimization code was adapted to search for the optimal endwall shape for these unconventional machines. The optimal shape reduces shock losses and deviation angles and provides a significant gain in efficiency and work extraction. Finally, a novel technique is proposed to design the three-dimensional shape of the rotor based on the method of characteristics and tailored on the flow delivered by the stator.