bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the effectiveness of a broader approach to reading instruction: A single-case study of a reading intervention
Authors: Dunford Saya , Hill Vivian 
Published: March 2023

AimsThis small-scale study investigated outcomes from a reading intervention which taught a broader range of reading skills. The intervention followed recommendations made by Solity (2020), with instruction on high frequency words (HFWs), grapheme-phoneme correspondences (GPCs), and vocabulary, taught through frequent, distributed practise of skills and real books.MethodFive students in Year Five (all with English as an Additional Language and low levels of literacy skills) from an inner London Borough primary school took part in a reading intervention delivered daily over 3 months (45 sessions). A mixed methods single-case study design was implemented. Students were assessed pre- and post-intervention using interviews, Diagnostic Reading Assessment, questionnaires on students’ reading views and confidence, and fluency reading the 100 HFWs and GPCs. Questionnaire and interview feedback were gained from education staff. Quantitative data were analysed using descriptive statistics. Themes and quotes from qualitative data provided an understanding of the students’ and staffs’ views.FindingsResults indicated increases in students’ knowledge of HFWs and GPCs, and students showed improvements in reading ability in at least one skill assessed. Most students felt they were better and more confident at reading, although views towards reading were mixed.LimitationsThe small sample size and lack of control group mean that results may be difficult to generalise to other school populations.ConclusionsThis research goes some way to demonstrating the efficacy of a reading intervention approach which focuses on teaching a broader range of skills compared to a sole focus on systematic synthetic phonics.
استعمال نظم المعلومات والتقنيات الحديثة في معرفة أسباب اختفاء ‏المواقع الآثارية واندثار معالمها
Authors: خلف اوراس فاضل , السامرائي نسيم عدنان حميدي 
Published: March 2023

يهدف هذا البحث إلى استعمال التقنيات الحديثة البرمجية(نظم المعلومات الجغرافية) في مجال الآثار ومعرفة ‏المشاكل التي تؤدي إلى اختفاء واندثار المعالم الآثارية، وفي هذا البحث تمّ استعمال برنامج ‏ArcMap Pro‎‏ في إنشاء الخرائط الرقمية للمواقع الآثارية المستهدفة مدينة المتوكلية في سامراء لفترتين من الزمن ‏بالاعتماد على مرئيات فضائية‏‎.‎ وبالإمكانيات التي يقدمها نظم المعلومات الجغرافية تمّ رسم خارطة تمثل الأماكن التي تمّ ‏استعمالها في السكن أو الزراعة بالاعتماد على مرئية فضائية للمنطقة في العام ‎‏ 2019المصدر(SASplanet،ESRI\ArcGIS.Imagery) بواسطة القمر(Landsat7) ومرئية فضائية أخرى للمنطقة نفسها في العام 1968 المصدر(‏‎‎‎(CORONA SITE للقمر (KH–7 GAMBIT) تمثل ‏المناطق الآثارية ، التي اعتمد عليها لمعرفة نسبة الاندثار في فترةٍ من الزمن.‏
HUBUNGAN PENGETAHUAN DAN SIKAP MASYARAKAT TERHADAP PERILAKU PENGGUNAAN ANTIBIOTIK PADA PASIEN DI PUSKESMAS TAKTAKAN KOTA SERANG
Authors: Haryanto Kusno , Ekadipta Ekadipta , Suherla Siti 
Published: March 2023

Penyakit infeksi menjadi sebuah permasalahan kesehatan yang penting untuk keluarga di sekitar terutama di Indonesia selaku negara yang berkembang. Obat yang terkadang diresepkan oleh dokter serta dipergunakan dalam menanggulangi permasalahan itu di antaranya antibiotik. Resistensi bakteri kepada antibiotik yang ada pada semua dunia dengan cepat, memberikan penurunan terhadap efikasi antibiotik yang telah terjadi perubahan sejarah pengobatan dan telah melakukan penyelamatan terhadap jutaan nyawa manusia. Krisis resistensi bakteri kepada antibiotik utama pokok tersebut dikarenakan oleh pemamfaatan antibiotik yang berlebihan dan tidak tepat. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara pengetahuan dan sikap terhadap perilaku penggunaan antibiotik pada puskesmas Taktakan, Kota Serang. Jenis penelitian yang dipergunakan merupakan penelitian kuantitatif dengan pendekatan Cross sectional study. Populasi pada riset ini merupakan pasien yang berkunjung pada puskesmas Taktakan Kota Serang Banten pada bulan April 2021 dengan ukuran sampel sebesar 100 responden. Analisis data univariat terhadap pengetahuan, prilaku, dan sikap dilakukan berdasarkan arikunto. Sedangkan pengujian analisis multivariate dilakukan dengan menggunakan analisis korelasi pearson product moment. Berdasarkan uji univariat didapat bahwa 37% responden masih memiliki pengetahuan yang kurang terhadap penggunaan antibiotik. Walaupun memiliki pengetahuan yang kurang responden mampu memiliki perilaku yang cukup (44%) dan bersikap baik (54%) dalam penggunaan antibiotik. Sedang hasil uji multivariate menunjukan bahwa pengetahuan dan sikap yang dimiliki responden berhubungan dengan perilaku dalam penggunaan antibiotik.
Evaluation of olfactory threshold changes in patients treated with rapid maxillary expansion
Authors: Yıldırım Mücahid , Erdur Emire Aybüke , Erdur Ömer , Metli Şule Nur 
Published: March 2023

Aim: Rapid maxillary expansion (RME) provides an orthopedic effect that solves the problem of transverse deficiency of the maxilla. Moreover, it contributes positively to the functioning of the entire nasopharynx by increasing the cross-sectional area and volume of the nasal tract, thus reducing airway resistance. The aim of this study was to evaluate the changes in olfactory threshold after RME treatment of patients with maxillary transverse deficiency.
Methodology: Olfactory threshold and identification tests as well as acoustic rhinometry parameter (Volume1, MCA1, Volume2, MCA2) measurements were conducted for 40 patients (11–16 years) before treatment (T0) and 6 months after (T1) rapid maxillary expansion application.
Results: A significant improvement was observed when the olfactory threshold values at T0 (0.96 ± 0.07) and T1 (0.79 ± 0.13) (p < 0.001) were compared. A significant improvement was also observed upon comparing the identification test results at T0 (0.63 ± 0.13) and T1 (0.79 ± 0.11) (p < 0.001). The acoustic rhinometry results showed a significant increase in Volume 1, MCA1, Volume 2 and MCA2 in the right and left nasal cavities after treatment (p < 0.001).
Conclusion: In this study, acoustic rhinometry showed that nasal cavity area and volume increased in patients who underwent rapid maxillary expansion therapy. Further, the olfactory functions measured by the olfactory threshold test and identification test improved significantly.

How to cite this article:
Yıldırım M, Erdur EA, Erdur Ö, Metli ŞN. Evaluation of olfactory threshold changes in patients treated with rapid maxillary expansion. Int Dent Res 2022;12(Suppl.1):90-6. https://doi.org/10.5577/intdentres.435

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Analysis of Water Quality of a Lentic Water Reservoir of Arrah, Bihar (India) by Application of the Water Quality Index (WQI)
Authors: Gupta Anjali 
Published: March 2023

The water quality index (WQI) is a dimensionless number using arbitrary grading curves to normalize values by combining various characteristics of water quality water into a single value. It has been utilized traditionally to evaluate the water quality for rivers, streams, lakes, and other water sources. So the purpose of the current investigation is to evaluate the WQI of a lentic water body in Arrah (Bihar). For the three seasons' WQI calculations i.e. Monsoon, winter and summer, physico-chemical variables were tracked. For calculating WQI ten physico-chemical parameters were recorded. pH ranges between 7.54-7.86, total alkalinity from 112-167, total hardness 70-160, TDS 325-487, Calcium 43-67, Magnesium 26-130, Chloride 30-52, Sulphate 16-36, DO 5.2-5.7 and Nitrate from 21-34.
The permitted levels were met for the variables total hardness, pH, TDS, Calcium, Dissolved Oxygen, Chloride, Nitrate and Sulphate. On the other hand, the values of total alkalinity were higher in the winter and summer seasons, and the value of magnesium in the summer season was higher than prescribed by Indian Standards.
Chemotherapy-related agranulocytosis as a predictive factor for germline BRCA1 pathogenic variants in breast cancer patients: a retrospective cohort study
Authors: Lang Noémie , Ayme Aurélie , Ming Chang , Combes Jean‑Damien , Chappuis Victor N. , Friedlaender Alex , Vuilleumier Aurélie , Sandoval José L. , Viassolo Valeria , Chappuis Pierre O. , Labidi-Galy S. Intidhar 
Published: March 2023

BACKGROUND: Carriers of germline pathogenic variants of the BRCA1 gene (gBRCA1) tend to have a higher incidence of haematological toxicity upon exposure to chemotherapy. We hypothesised that the occurrence of agranulocytosis during the first cycle of (neo-)adjuvant chemotherapy (C1) in breast cancer (BC) patients could predict gBRCA1 pathogenic variants.
PATIENTS AND METHODS: The study population included non-metastatic BC patients selected for genetic counselling at Hôpitaux Universitaires de Genève (Jan. 1998 to Dec. 2017) with available mid-cycle blood counts performed during C1. The BOADICEA and Manchester scoring system risk-prediction models were applied. The primary outcome was the predicted likelihood of harbouring gBRCA1 pathogenic variants among patients presenting agranulocytosis during C1.
RESULTS: Three hundred seven BC patients were included: 32 (10.4%) gBRCA1, 27 (8.8%) gBRCA2, and 248 (81.1%) non-heterozygotes. Mean age at diagnosis was 40 years. Compared with non-heterozygotes, gBRCA1 heterozygotes more frequently had grade 3 BC (78.1%; p = 0.014), triple-negative subtype (68.8%; p <0.001), bilateral BC (25%; p = 0.004), and agranulocytosis following the first cycle of (neo-)adjuvant chemotherapy (45.8%; p = 0.002). Agranulocytosis and febrile neutropenia that developed following the first cycle of chemotherapy were independently predictive for gBRCA1 pathogenic variants (odds ratio: 6.1; p = 0.002). The sensitivity, specificity, positive predictive value, and negative predictive value for agranulocytosis predicting gBRCA1 were 45.8% (25.6–67.2%), 82.8% (77.5–87.3%), 22.9% (6.1–37.3%), and 93.4% (88.9–96.4%), respectively. Agranulocytosis substantially improved the positive predictive value of the risk-prediction models used for gBRCA1 evaluation.
CONCLUSION: Agranulocytosis following the first cycle of (neo-)adjuvant chemotherapy is an independent predictive factor for gBRCA1 detection in non-metastatic BC patients.
Alcohol use as a risk factor for sexually transmitted infections: A systematic review and conclusions for prevention
Authors: Llamosas-Falcón Laura , Hasan Omer S.M. , Shuper Paul A. , Rehm Jürgen 
Published: March 2023

Alcohol use has been associated with multiple sexual risk behaviors and outcomes, such as condomless sex, multiple sexual partners, unwanted pregnancy and sexually transmitted infections (STI). The aim of this review was to present updated evidence to demonstrate an association and to establish causality between alcohol consumption and STI risk, as well as to present interventions that reduce alcohol consumption and its effect on STIs. We conducted a systematic review according to the PRISMA guidelines using PUBMED and EMBASE. Narrative and systematic reviews, cohort studies, and case-control studies were included. Any type of alcohol use was considered as the exposure variable, with the outcome restricted to non-HIV STIs, as reviews on alcohol use and HIV already exist. In total, 18 publications satisfied the inclusion criteria. The evidence suggests that there is an association between alcohol use, especially heavy drinking occasions, and STIs, with 9 articles finding a statistical significant association. With respect to decision-making and sexual behavior, there is good evidence, including experimental evidence, that alcohol use increases risk-taking sexual behavior. It is important to have a deeper understanding of the association to develop effective prevention programs at community and individual levels. Preventive interventions should be implemented targeting the general population, in addition to specific campaigns directed at vulnerable subpopulations in order to reduce the risks.
Traditional Uses and Anticancer Potential of the Combretum Genus: A Literature Review
Authors: Coulidiati Tangbadioa Hervé 
Published: March 2023

Background: Cancer incidence is increasing annually in all countries. So, it is nowadays a great burden for the different nations of the world. Research for new therapeutics is becoming an urgent need, particularly for intractable and chemoresistant cancer cases. The solutions can still be found by investigating natural products which are recognized as promising sources of bioactive compounds with a potential for the discovery of new preventive and therapeutic anticancer agents.
Methodology: The present work used databases such as Pubmed, Science Direct and Google scholar to investigate the ethnobotanical uses of some Combretum species in the literature. It also allowed us to summarize some pharmacological studies on Combretum species.
Results: This review gathers all available traditional uses and cytotoxicity studies of Combretum species in the literature. Special focus is given to pharmacological studies highlighting isolated potential anticancer molecules. These molecules present potent cytotoxic effect on various cancer cell lines and may contribute to improving the health of people suffering from various cancer diseases.
Conclusion: The Combretum species are widely used in folk medicine for the treatment of several pathologies including cancers. This study is of fundamental importance in highlighting Combretum species as a potential source for research of new anticancer compounds.
Synthesis of 5‐Trifluoromethyl‐1,4‐dihydro‐1,2,4‐triazines via Base‐mediated [3+3] Cycloaddition of Nitrile Imines and CF3‐Imidoyl Sulfoxonium Ylides
Authors: Sun Yue , Ling Sihao , Duan Yubo , Li Jingxian , Chen Zhengkai , Wu Xiao‐Feng 
Published: March 2023

AbstractAn approach for the construction of 5‐trifluoromethyl‐1,4‐dihydro‐1,2,4‐triazines has been developed via base‐mediated [3+3] cycloaddition of in‐situ generated nitrile imines and CF3‐substituted imidoyl sulfoxonium ylides. The metal‐free protocol is characterized by readily available starting materials, mild conditions, a broad substrate scope, high efficiency, good synthetic prospect, and scalability.magnified image
Catalytic Biorefining of Natural Oils to Basic Olefinic Building Blocks of Proven Chemical Valorization Schemes
Authors: de Roo Stefanie , Einsiedler Felix , Mecking Stefan 
Published: March 2023

AbstractCatalytic transformation of renewable plant oils including microalgae and waste oil into industrially relevant α‐olefins in the C3 to C10 regime is demonstrated. The biorefinery concept is comprised of a catalytic sequence of ethenolysis, double bond isomerization, and a subsequent ethenolysis, thereby cutting and rearranging the fatty acid chains into valuable chemical building blocks. A benign extraction and reaction solvent, supercritical carbon dioxide (scCO2), is utilized.
Modeling of diffuse solar radiation exergy in Turkey: Comparison of diffuse fraction and diffusion coefficient models
Authors: Arslanoglu Nurullah 
Published: March 2023

AbstractIn this study, 19 regression models were established for the prediction of exergy value of monthly average diffuse solar radiation with a single or multiple input predictor (Relative sunshine duration, clearness index, relative humidity, and air temperature). Five model categories were defined depending on the diffuse fraction and diffusion coefficient. The most frequently used statistical indicators were used to determine the performance of the empirical models. The global performance indicator (GPI) method was used to determine the accuracy ranking of the models. Consequently, the results show a good agreement with the values ​​estimated from the regression models and the measurement data. The regression models established in this study can be used with great accuracy to evaluate the monthly average diffuse solar radiation exergy in the regions under consideration or in similar climatic conditions.
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Authors: Kiyono Kenjiro , Mabuchi Shun , Otaka Akihisa , Iwasaki Yasuhiko 
Published: March 2023

The cover image is based on the Research Article Bone‐targeting polyphosphodiesters that promote osteoblastic differentiation by Kenjiro Kiyono et al., https://doi.org/10.1002/jbm.a.37499.
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Characterizing different types of black fountain pen ink using the chemical approach
Authors: Tung Fang‐Hsiu , Wu Kuan‐Lu , Wang Hsueh‐Ting , Chen Sung‐Fang 
Published: March 2023

AbstractFountain pen ink contains dyes, pigments, or nanoparticles as colorants; water and ethylene glycol or an organic solvent as the vehicle. The dyes in fountain pen ink are usually negatively charged acid dyes. In this study, various types of black fountain pen ink (5 dye‐based and 5 nanoparticle‐based) were investigated by ultraviolet–visible (UV–Vis) absorption spectroscopy, Ion Pair High Performance Liquid Chromatography Diode‐Array Detector (IP‐HPLC‐DAD), Matrix Assisted Laser Desorption/Ionization Time‐of‐Flight Mass Spectrometry (MALDI‐TOF‐MS), and Liquid Chromatography Quadrupole Time‐of‐Flight Mass Spectrometry (LC‐Q/TOF‐MS) analysis. UV–Vis spectroscopy of fountain pen ink samples showed different profiles despite their similar color. MALDI‐TOF‐MS analyses successfully differentiated 10 of the inks. Nanoparticle‐based ink, which is usually darker than dye‐based ink, showed the same UV absorption at 240 nm. The use of LC‐Q/TOF‐MS, however, allowed the 5 dye‐based fountain pen ink samples to be differentiated from one another. On the basis of the combined results of all analytical methods mentioned above, the discriminating power values were 0.71–1.00. Among them, MALDI‐TOF‐MS could successfully distinguish fountain pen ink samples with similar black colors and provide an easy analytical approach for the differentiation and identification of various types of fountain pens.
Genome‐based survey of the SARS‐CoV‐2 BF.7 variant from Asia
Authors: Scarpa Fabio , Giovanetti Marta , Azzena Ilenia , Locci Chiara , Casu Marco , Fiori Pier Luigi , Ciccozzi Alessandra , Imperia Elena , Bazzani Liliana , Borsetti Alessandra , Maruotti Antonello , Pascarella Stefano , Sanna Daria , Ciccozzi Massimo 
Published: March 2023

AbstractThe SARS‐CoV‐2 BF.7 variant represents one of the most recent subvariant under monitoring. At the beginning of the 2023 it caused several concerns especially in Asia because of a resurge in COVID‐19 cases. Here we perform a genome‐based integrative approach on SARS‐CoV‐2 BF.7 to shed light on this emerging lineage and produce some consideration on its real dangerousness. Both genetic and structural data suggest that this new variant currently does not show evidence of an high expansion capability. It is very common in Asia, but it appears less virulent than other Omicron variants as proved by its relatively low evolutionary rate (5.62 × 10−4 subs/sites/years). The last plateau has been reached around December 14, 2022 and then the genetic variability, and thus the viral population size, no longer increased. As already seen for several previous variants, the features that may be theoretically related to advantages are due to genetic drift that allows to the virus a constant adaptability to the host, but is not strictly connected to a fitness advantage. These results have further pointed that the genome‐based monitoring must continue uninterruptedly to be prepared and well documented on the real situation.
Bioactive molecules from fungal endophytes and their applications in pharmaceutical industries: challenges and future scope
Authors: Anand Kumar , Kumar Vijay , Prasher Indu Bhushan , Sethi Megha , Raj Harsh , Ranjan Himanshu , Chand Subhash , Pandey Gaurav Kumar 
Published: March 2023

AbstractMedicinal plants are an important source of bioactive compounds and have been used to isolate various bioactive compounds having industrial applications. The demand for plants derived bioactive molecules is increasing gradually. However, the extensive use of these plants to extract bioactive molecules has threatened many plant species. Moreover, extracting bioactive molecules from these plants is laborious, costly, and time‐consuming. So, some alternative sources and strategies are urgently needed to produce these bioactive molecules similar to that of plant origin. However, the interest in new bioactive molecules has recently shifted from plants to endophytic fungi because many fungi produce bioactive molecules similar to their host plant. Endophytic fungi live in mutualistic association within the healthy plant tissue without causing disease symptoms to the host plant. These fungi are a treasure house of novel bioactive molecules having broad pharmaceutical, industrial, and agricultural applications. The rapid increase in publications in this domain over the last three decades proves that natural product biologists and chemists are paying great attention to the natural bioactive products from endophytic fungi. Though endophytes are source of novel bioactive molecules but there is need of advanced technologies like clustered regularly interspaced short palindromic repeats and CRISPR‐associated protein 9 (CRISPR‐Cas9) and epigenetic modifiers to enhance the production of compounds having industrial applications. This review provides an overview of the various industrial applications of bioactive molecules produced by endophytic fungi and the rationale behind selecting specific plants for fungal endophyte isolation. Overall, this study presents the current state of knowledge and highlights the potential of endophytic fungi for developing alternative therapies for drug‐resistant infections.
A retrospective study of 129 patients with plasma cell balanitis
Authors: Jormanainen Anniina , Pasternack Camilla , Pasternack Rafael 
Published: March 2023

AbstractBackgroundPlasma cell balanitis (PCB) is a chronic inflammatory dermatosis of the glans penis and prepuce, typically presenting as discrete shiny bright red plaques. Research on PCB is scarce, with case reports and small series. The aetiology, incidence and prevalence of PCB remain unclear. Circumcision is considered as the treatment of choice. Topical treatments such as topical corticosteroids, calcineurin inhibitors, fucidic acid and imiquimod have been widely used, but they lack evidence of efficacy.ObjectivesThe objective of this study was to investigate the clinical profiles, treatment methods and outcomes of PCB patients in a relatively large cohort.MethodsWe concluded a retrospective study of 129 patients with the diagnosis of PCB between 1 January 2003 and 31 December 2018 at Tampere University Hospital (TAYS) dermatology department.ResultsThe majority of patients were treated with topical treatments only, while 31 patients (24%) eventually underwent circumcision. The most used and most effective topical treatments were tacrolimus (0.03% or 0.1%) and clobetasol propionate. Those treated with circumcision had a shorter follow‐up time (median 8 months vs. 47 months, p = 0.002) and were more likely to reach remission (46% vs. 16%, p = 0.002) compared with those treated with only topical treatments. Patients with more severe symptoms were more often treated with several topical treatments and to undergo circumcision, and they were more likely to ultimately reach remission. The follow‐up time was longer among patients with a histopathologic diagnosis than with a clinical diagnosis (median 16 months vs. 6 months, p = 0.01).ConclusionsTopical treatments are rarely curative, but among them tacrolimus and topical corticosteroids show the strongest evidence of efficacy. The rate of remission is significantly better among those circumcised, and it is to be considered already at an early stage. Further studies are needed to find the best care management for PCB.