bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome analysis of infrapatellar fat pad partial resection or preservation in patients with anterior cruciate ligament reconstruction
Authors: Wen Yixin , Xu Feng , Liu Yang , Zhi Kaining , Tan Junfeng , Jiang Yong , Li Minghui , Zhang Hui 
Published: April 2023

AbstractThe infrapatellar fat pad (IPFP) is one of the structures surrounding the knee joint that obscures exposure in minimally arthroscopy anterior cruciate ligament reconstruction (ACLR). Most surgeons excise the partial fat pad for better exposure of the knee. However, whether removal of IPFP in ACLR remained inconclusive. The purpose of this study was to investigate clinical outcomes of IPFP preservation or resection in patients with primary hamstring-graft ACLR. A total of 104 patients were assigned to receive either IPFP-R (n = 55) or IPFP-P (n = 49). There were no significant preoperative differences between the two groups. The anterior knee pain (AKP) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) in the two groups both recovered compared with those at baseline, but the IPFP-P group recovered more significantly at 3-, 6-, 12-month, and 3-, 6-month of follow-up, respectively. When assessing the KOOS subclasses using minimum perceptible clinical improvement (MPCI), patients with IPFP-R failed to make significant improvement at 3 months in the symptoms, pain and sports subsets of the KOOS. Knee-related complications were not significantly different between the two groups, while the resection group had a higher incidence. These results suggested that ACLR with primary hamstring grafts can achieve good effects whether performed with IPFP resection or preservation; however, the improvements in anterior knee pain and knee joint functions are better for the patients with IPFP preservation. Therefore, surgeons should avoid the resection of IPFP as much as possible while fully exposing the wild view to ensure the ACLR.
MagicCubePose, A more comprehensive 6D pose estimation network
Authors: Li Fudong , Gao Dongyang , Huang Qiang , Li Wei , Yang Yuequan 
Published: April 2023

AbstractMost of the current mainstream 6D pose estimation methods use template or voting-based methods. Such methods are usually multi-stage or have multiple assumptions and post-correction, which will cause a certain degree of information redundancy and increase the computational cost, their real-time detection performance is poor. We point out that traditional path aggregation networks introduce new errors, therefore, we propose a loss function: MagicCubeLoss, a portable module: MagicCubeNet, and the corresponding 6D pose estimation model: MagicCubePose. MagicCubePose has good expansion performance and can build more efficient models for different calculation power and scenarios. Experiments show that our model has good real-time detection performance and the highest ADD(-S) accuracy.
T-cell specific antibody induction versus corticosteroid induction immunosuppression for liver transplant recipients: a meta-analysis
Authors: Jung Woo-Seok , Kuh Jae Hee , Lim Leerang , Yoo Hae Kyung , Ju Jae-Woo , Lee Ho-Jin , Kim Won Ho 
Published: April 2023

AbstractCorticosteroids remain the mainstay of immunosuppression for liver transplant recipients despite several serious complications including infection, hepatitis C virus (HCV) recurrence, diabetes mellitus (DM), and hypertension. We attempted to compare the safety and efficacy of T-cell specific antibody induction with complete corticosteroid avoidance. We searched MEDLINE, EMBASE, and Cochrane central library. Randomized controlled trials comparing T-cell specific antibody induction with corticosteroid induction immunosuppression were included. Our primary outcome was the incidence of biopsy-proven acute rejection. Eleven trials involving 1683 patients were included. The incidence of acute rejection was not significantly different between the antibody and steroid induction groups (risk ratio [RR] 0.85, 95% confidence interval [CI] 0.72, 1.01, P = 0.06, I2 = 0%). However, T-cell specific antibody induction significantly reduced the risk of cytomegalovirus infection (RR 0.48, 95% CI 0.33, 0.70, P = 0.0002, I2 = 3%), HCV recurrence (RR 0.89, 95% CI 0.80, 0.99, P = 0.03, I2 = 0%), DM (RR 0.41, 95% CI 0.32, 0.54, P < 0.0001, I2 = 0%) and hypertension (RR 0.71, 95% CI 0.55, 0.90, P = 0.005, I2 = 35%). Trial sequential analysis for acute rejection showed that the cumulative z-curve did not cross the Trial sequential boundary and the required information size was not reached. T-cell specific antibody induction compared to corticosteroid induction seems to significantly reduce opportunistic infections including cytomegalovirus infection and HCV recurrence and metabolic complications including DM and hypertension. However, given the insufficient study power, low quality of evidence, and heterogeneous immunosuppressive regimens, our results should be cautiously appreciated.
Aberrant topology of white matter networks in patients with methamphetamine dependence and its application in support vector machine-based classification
Authors: Cheng Ping , Li Yadi , Wang Gaoyan , Dong Haibo , Liu Huifen , Shen Wenwen , Zhou Wenhua 
Published: April 2023

AbstractBrain white matter (WM) networks have been widely studied in neuropsychiatric disorders. However, few studies have evaluated alterations in WM network topological organization in patients with methamphetamine (MA) dependence. Therefore, using machine learning classification methods to analyze WM network topological attributes may give new insights into patients with MA dependence. In the study, diffusion tensor imaging-based probabilistic tractography was used to map the weighted WM networks in 46 MA-dependent patients and 46 control subjects. Using graph-theoretical analyses, the global and regional topological attributes of WM networks for both groups were calculated and compared to determine inter-group differences using a permutation-based general linear model. In addition, the study used a support vector machine (SVM) learning approach to construct a classifier for discriminating subjects with MA dependence from control subjects. Relative to the control group, the MA-dependent group exhibited abnormal topological organization, as evidenced by decreased small-worldness and modularity, and increased nodal efficiency in the right medial superior temporal gyrus, right pallidum, and right ventromedial putamen; the MA-dependent group had the higher hubness scores in 25 regions, which were mainly located in the default mode network. An SVM trained with topological attributes achieved classification accuracy, sensitivity, specificity, and kappa values of 98.09% ± 2.59%, 98.24% ± 4.00%, 97.94% ± 4.26%, and 96.18% ± 5.19% for patients with MA dependence. Our results may suggest altered global WM structural networks in MA-dependent patients. Furthermore, the abnormal WM network topological attributes may provide promising features for the construction of high-efficacy classification models.
Assessment of a multisite standardized biospecimen collection protocol for immune phenotyping in neurodevelopmental disorders
Authors: Cleary Shane , Teskey Grace , Mathews Craig , Sachachar Russell J. , Nicolson Robert , Weksberg Rosanna , Anagnostou Evdokia , Bowdish Dawn M. E. , Foster Jane A. 
Published: April 2023

AbstractMultisite collection and preservation of peripheral blood mononuclear cells (PBMCs) for centralized analysis is an indispensable strategy for large cohort immune phenotyping studies. However, the absence of cross-site standardized protocols introduces unnecessary sample variance. Here we describe the protocol implemented by the Province of Ontario Neurodevelopmental Disorders (POND) Network's immune platform for the multisite collection, processing, and cryopreservation of PBMCs. We outline quality control standards and evaluate the performance of our PBMC processing and storage protocol. We also describe the Child Immune History Questionnaire results, an assessment tool evaluating pre-existing immune conditions in children with neurodevelopmental disorders (NDDs). Cell viability was assessed in samples from 178 participants based on strict quality control criteria. Overall, 83.1% of samples passed quality control standards. Samples collected and processed at the same site had higher quality control pass rates than samples that were collected and subsequently shipped to another site for processing. We investigated if freezer time impacted sample viability and found no difference in mean freezer time between samples that passed and failed quality control. The Child Immune History Questionnaire had a response rate of 87.1%. The described protocol produces viable samples that may be used in future immune phenotyping experiments.
Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site
Authors: Ghafoori Seyed Mohammad , Petersen Gayle F. , Conrady Deborah G. , Calhoun Brandy M. , Stigliano Matthew Z. Z. , Baydo Ruth O. , Grice Rena , Abendroth Jan , Lorimer Donald D. , Edwards Thomas E. , Forwood Jade K. 
Published: April 2023

AbstractInfluenza virus (IV) causes several outbreaks of the flu each year resulting in an economic burden to the healthcare system in the billions of dollars. Several influenza pandemics have occurred during the last century and estimated to have caused 100 million deaths. There are four genera of IV, A (IVA), B (IVB), C (IVC), and D (IVD), with IVA being the most virulent to the human population. Hemagglutinin (HA) is an IVA surface protein that allows the virus to attach to host cell receptors and enter the cell. Here we have characterised the high-resolution structures of seven IVA HAs, with one in complex with the anti-influenza head-binding antibody C05. Our analysis revealed conserved receptor binding residues in all structures, as seen in previously characterised IV HAs. Amino acid conservation is more prevalent on the stalk than the receptor binding domain (RBD; also called the head domain), allowing the virus to escape from antibodies targeting the RBD. The equivalent site of C05 antibody binding to A/Denver/57 HA appears hypervariable in the other H1N1 IV HAs. Modifications within this region appear to disrupt binding of the C05 antibody, as these HAs no longer bind the C05 antibody by analytical SEC. Our study brings new insights into the structural and functional recognition of IV HA proteins and can contribute to further development of anti-influenza vaccines.
Iterative heterogeneous graph learning for knowledge graph-based recommendation
Authors: Liu Tieyuan , Shen Hongjie , Chang Liang , Li Long , Li Jingjing 
Published: April 2023

AbstractIncorporating knowledge graphs into recommendation systems has attracted wide attention in various fields recently. A Knowledge graph contains abundant information with multi-type relations among multi-type nodes. The heterogeneous structure reveals not only the connectivity but also the complementarity between the nodes within a KG, which helps to capture the signal of potential interest of the user. However, existing research works have limited abilities in dealing with the heterogeneous nature of knowledge graphs, resulting in suboptimal recommendation results. In this paper, we propose a new recommendation method based on iterative heterogeneous graph learning on knowledge graphs (HGKR). By treating a knowledge graph as a heterogeneous graph, HGKR achieves more fine-grained modeling of knowledge graphs for recommendation. Specifically, we incorporate the graph neural networks into the message passing and aggregating of entities within a knowledge graph both at the graph and the semantic level. Furthermore, we designed a knowledge–perceiving item filter based on an attention mechanism to capture the user’s potential interest in their historical preferences for the enhancement of recommendation. Extensive experiments conducted on two datasets in the context of two recommendations reveal the excellence of our proposed method, which outperforms other benchmark models.
Dietary factors potentially impacting thiaminase I-mediated thiamine deficiency
Authors: Edwards Katie A. , Randall Eileen A. , Wolfe Patricia C. , Angert Esther R. , Kraft Clifford E. 
Published: April 2023

AbstractFish population declines from thiamine (vitamin B1) deficiency have been widespread in ecologically and economically valuable organisms, ranging from the Great Lakes to the Baltic Sea and, most recently, the California coast. Thiamine deficiencies in predatory fishes are often attributed to a diet of prey fishes with high levels of thiamine-degrading (e.g., thiaminase) enzymes, such as alewives, rainbow smelt, and anchovies. Since their discovery, thiaminase I enzymes have been recognized for breaking down thiamine into its pyrimidine and thiazole moieties using various nucleophilic co-substrates to afford cleavage, but these studies have not thoroughly considered other factors that could modify enzyme activity. We found the thiaminase I enzyme from Clostridium botulinum efficiently degrades thiamine in the presence of pyridoxine (vitamin B6) as a co-substrate but has relatively limited activity in the presence of nicotinic acid (vitamin B3). Using fluorescence measurements, thiamine degradation in an over-the-counter complete multivitamin formulation was inhibited, and a B-complex formulation required co-substrate supplementation for maximal thiamine depletion. These studies prompted the evaluation of specific constituents contributing to thiaminase I inhibition by both chromatography and fluorescence assays: Cu2+ potently and irreversibly inhibited thiamine degradation; ascorbic acid was a strong but reversible inhibitor; Fe2+, Mn2+ and Fe3+ modulated thiamine degradation to a lesser degree. The enhancement by pyridoxine and inhibition by Cu2+ extended to thiaminase-mediated degradation from Burkholderia thailandensis, Paenibacillus thiaminolyticus, and Paenibacillus apiarius in tryptic soy broth supernatants. These co-substrate limitations and the common presence of inhibitory dietary factors complement recent studies reporting that the intended function of thiaminase enzymes is to recycle thiamine breakdown products for thiamine synthesis, not thiamine degradation.
Surgical management and clinical outcome of cervical, thoracic and thoracolumbar spinal tuberculosis in a middle-European adult population
Authors: Kilinc Fatma , Setzer Matthias , Behmanesh Bedjan , Jussen Daniel , Geßler Florian , Prinz Vincent , Czabanka Marcus 
Published: April 2023

AbstractSpinal tuberculosis is due to globalization no longer a disease limited to developing nations. It remains in Germany a rarity and still a difficult diagnosis. Here we analyzed patients with spinal tuberculosis treated at our neurosurgical department. According to the infected anatomic segment, patients were assigned in one of three groups. Surgery was performed when neurological deficit due to mechanical compression, deformity, instability, severe pain, necrotic bone or failure to respond to anti-tuberculous treatment were observed. We identified 34 patients with spinal tuberculosis who underwent surgical treatment. In the cervical spinal tuberculosis group, there were 15 cases (46.9%) In most cases treatment consisted of spinal instrumentation. In the thoracic group, 10 cases (29.4%) were observed. The treatment was performed by dorsolateral spinal instrumentation. For the thoracolumbar group, 9 cases (26.4%) were observed. In most cases dorsolateral spinal instrumentation was performed. One patient in the first group and one patient in the third group relapsed after operation. A second surgery was necessary. Patients with chronic back pain, immigration background and/or neurological deficit spinal TB should be considered as a differential diagnosis. Combined surgical intervention and medical treatment is associated with a favorable outcome.
Factors Related to College Major Selection in Communication Sciences and Disorders: Application of the Theory of Planned Behavior
Authors: Choo Ai Leen , Gurevich Naomi , Dadzie Nana , Reidenbach Kayla , Laxman Malini , Ngo Kelley 
Published: April 2023

Purpose:The growing number of racial and ethnic minorities in the United States is not reflected in the speech-language pathology profession, with ramifications for the diverse communities it serves. Despite decades of initiatives, the numbers of racial and ethnic minorities entering the profession have been modest. The aim of this pilot study is to explore potential factors that influence decision making for a college major that could inform strategies for underrepresented racial and ethnic minority (URM) recruitment into communication sciences and disorders (CSD) programs.Method:The theory of planned behavior was used as a framework to explore the influences on students' selection of college majors with a particular focus on speech-language pathology. Students enrolled and not enrolled in CSD programs were surveyed about their attitudes, perceived behavioral control, and subjective normative pressure (e.g., perceptions of race and ethnic representation, familiarity with speech-language pathology, and family education).Results:There were significant differences between CSD and non-CSD respondents, and between URM and White respondents in their perception of representation and exposure to the profession. The majority of URM students reported that race and ethnic representation is important in their chosen job. URM students were less likely than White students to know anyone who has received speech-language therapy or who is a speech-language pathologist.Conclusion:Findings suggest that initiatives to increase representation and diverse role models, and early exposure to the profession for URM students should be areas of focus in the efforts to diversify the profession.
The energy spectrum of ultra-high energy cosmic rays measured at the Pierre Auger Observatory and the Telescope Array
Authors: Bergman D. R. , Deligny O. , Fenu F. , Fujii T. , Fujita K. , Kim J. H. , Lhenry-Yvon I. , Maris¸ I. , Luce Q. , Roth M. , Salamida F. , Tsunesada Y. , Verzi V. ,   for the Pierre Auger,   the Telescope Array
Published: April 2023

In the study of cosmic rays, the measurement of the energy spectrum of the primaries is one of the main issues and provides fundamental information on the most energetic phenomena in the Universe. At ultrahigh energies, beyond 1018 eV, the cosmic rays are studied by the two largest observatories built so far, the Pierre Auger Observatory and the Telescope Array. Both observatories are based on a hybrid design and reported a measurement of the energy spectrum using the high duty cycle of the surface detector and the calorimetric estimation of the energy scale provided by the fluorescence detector.
The differences among the reported spectra are scrutinized by a working group made by members of the Pierre Auger and Telescope Array Collaborations. The two measurements have been found well in agreement below 1019 eV while, at higher energies, they show an energy-dependent difference that is beyond the systematic uncertainties associated to the energy scale.
In this contribution we review the status and perspectives of the working group activities including new studies aiming at addressing the impact on the flux measurement at the highest energies of potential biases in the estimation of the shower size.
Absolute calibration of the JEM-EUSO photodetection modules
Authors: Trofimov Daniil , Belov Alexander , Blin-Bondil Sylvie , Creusot Alexandre , Klimov Pavel , Parizot Etienne , Prévôt Guillaume ,   Collaboration
Published: April 2023

The JEM-EUSO (Joint Experiment Missions for Extreme Universe Space Observatory) collaboration constructs a series of balloon and orbital telescopes to detect fluorescent UV emission from the Earth atmosphere, with the primary aim to study ultra-high-energy cosmic rays (UHECRs) from space.
The detectors have wide field-of-view (more than 20 degrees FOV), high temporal resolution (1-2.5 µs) and high sensitivity provided by a large aperture. Currently, one of these detectors is operating onboard the International Space Station (Mini-EUSO). The next one is planned to be launched in the spring of 2023 (EUSO-SPB2) and another one is in preparation stage (K-EUSO). These projects use the same photo-detection modules (PDMs) composed of 36 multi-anode photomultiplier tubes (MAPMTs), each with 64 pixels, for a total of 2304 pixels. Mini-EUSO uses one PDM, EUSO-SPB2 uses three and the future full-scale missions will use several tens of PDMs.
In the process of preparing and testing of PDMs, a new technique was developed to characterize their performance and provide absolute calibration of the MAPMTs used in the different JEM-EUSO missions. The method provides the efficiency of each pixel (including the sub-pixel structures), as well as the actual area occupied by the different pixels on the photocathode of the MAPMT.
The method and its application to EUSO-SPB2 PDMs at different high voltages and in different modes of operation are presented.
Determinants of neonatal, infant and under-five mortalities: evidence from a developing country, Bangladesh
Authors: Murad Md Wahid , Abdullah A. B. M. , Islam Md Mazharul , Alam Md Mahmudul , Reaiche Carmen , Boyle Stephen 
Published: April 2023

AbstractWe investigated the macroeconomic determinants of neonatal, infant, and under-five mortalities in Bangladesh for the period 1991–2018 and discuss implications of the United Nations’ Sustainable Development Goal 3 (SDG 3) and Millennium Development Goal 4 (MDG 4) for developing countries. We used annual time series data and the econometric techniques of Fully Modified Ordinary Least Squares (FMOLS) and Dynamic Ordinary Least Squares (DOLS) regressions for analysis. Determinants most effective in combating neonatal, infant, and under-five mortalities include variables such as ‘protecting newborns against tetanus’, ‘increasing healthcare expenditure’, and ‘making sure births are attended by skilled healthcare staff’. Employing more healthcare workers and assuring more and improved healthcare provisions can further reduce the neonatal, infant, and under-five mortalities. Developing countries with similar macroeconomic profiles can achieve similar SDG 3 and MDG 4 outcomes by emulating the policies and strategies Bangladesh applied to reducing child mortalities over the last three decades.