bluuebunny/crossref_metadata_2025_split huggingface dataset:
Un architecte hygiéniste au service de l’Hôpital général de Paris à la fin du xviiie siècle
Authors: Lauro Marc 
Published: September 2023

Charles-François Viel (1745-1819) fut le dernier titulaire de la charge d’architecte de l’Hôpital général de Paris avant la disparition de cette institution en 17901. Il poursuivit sa carrière dans les années 1800 en tant qu’architecte des Hospices civils parisiens. Il participa alors, avec d’autres confrères, à la médicalisation du vaste patrimoine immobilier constitué des anciens bâtiments de l’Hôpital général ou des abbayes confisquées comme biens nationaux, avant d’être mis à disposition du département de la Seine sous la Convention thermidorienne. À ce titre, il fut chargé de la construction et de l’entretien de nombreux bâtiments hospitaliers dont la plupart disparurent au début du xxe siècle, tels que l’hospice Cochin ou l’infirmerie de la Pitié. Nous nous attacherons plus particulièrement à décrire les travaux entrepris par Viel pour alimenter en eau potable et évacuer les eaux sales dans les deux principaux établissements parisiens de l’Hôpital général qui, à la veille de la Révolution, accueillaient une population de 8 000 à 10 000 personnes : les maisons de la Salpêtrière et de Bicêtre.
Les bateaux-lavoirs lavallois ou l’exceptionnelle longévité d’une flotte buandière
Authors: Garnavault Sylvie 
Published: September 2023

À l’origine étaient les « arrivoirs », espaces aménagés en bord de Mayenne et servant principalement de lavoirs. Sous le Second Empire, la municipalité de Laval entreprend la construction de quais pour protéger et assainir la ville, sujette aux inondations. C’est ainsi qu’apparaissent les premiers bateaux-lavoirs destinés à permettre aux laveuses, professionnelles ou non, d’accéder à la rivière. Élément pittoresque local, mais surtout lieu de travail et de sociabilité pour les « poules d’eau » qui y travaillent durement, la flotte buandière lavalloise compte vingt-trois embarcations à la fin du xixe siècle.En 1969, l’un des deux derniers bateaux-lavoirs encore à quai cesse son activité en raison de la démocratisation de la machine à laver. Il s’agit du Saint-Julien, bateau à fond plat et double pont construit dans le Maine-et-Loire en 1904. L’étage supérieur servait de buanderie, mais également de logement pour le patron-buandier et sa famille. La cale constituait le lavoir proprement dit et les deux chaudières occupant l’espace central chauffaient l’eau pour les cuves placées au-dessus. Le bateau pouvait accueillir jusqu’à une quarantaine de laveuses.Depuis leur achat par la Ville, le Saint-Julien et son ancien voisin de quai, le Saint-Yves, ont été classés monuments historiques. Après leur naufrage simultané et leur sauvetage en 2009, le premier a été restauré puis remis à l’eau à son emplacement primitif où il accueille à nouveau des visiteurs. Le second est toujours en attente de restauration.Uniques en France, le Saint-Julien et le Saint-Yves sont aujourd’hui les derniers témoins d’une activité traditionnelle à jamais disparue.
Des eaux jaillissantes aux rejets d’immondices
Authors: Leroux Laure , Balbo Éric , Grany Jean-Claude , Conte Patrice 
Published: September 2023

Du captage des sources jusqu’aux exhaures vers la Vienne en passant par les fontaines, se déploie à Limoges un vaste réseau souterrain qui accompagne l’expansion de la ville depuis l’Antiquité et en démultiplie les ramifications au cours des époques modernes et médiévales. Outre son étendue, ce réseau se démarque par une riche documentation qui invite à en restituer les contours : données réglementaires issues des archives consulaires, sources iconographiques et cartographiques de l’époque moderne, mais aussi des analyses archéologiques menées par l’association ArchéA sur les souterrains de Limoges. La confrontation de ces différentes sources éclaire la problématique de l’hygiène dans la ville médiévale et moderne en renseignant la matérialité des infrastructures publiques – aqueducs, fontaines et exhaures – tout comme l’hygiène privée à partir d’exemples de dispositifs découverts dans les immeubles anciens de Limoges.
La maison et le jardin de Maurice Ravel à Montfort-l’Amaury (Yvelines)
Authors: Chauvin Agnès , Didier Marie-Hélène 
Published: September 2023

La maison et le jardin de Maurice Ravel à Montfort-l’Amaury (Yvelines) sont un précieux témoignage de la personnalité du compositeur qui les a aménagés et, plus largement, ils constituent un lieu de mémoire lié à la musique française et aux arts du début du xxe siècle. Pour les spécialistes, il s’agit là de la véritable exposition sur l’artiste. Cette maison et son jardin sont d’autant plus intéressants que, remplis de souvenirs, de rêves et de musique, ils forment une étonnante adéquation qui passionne les visiteurs. L’aménagement du jardin avec ses jeux d’eau, son plumetis de fleurs et son esprit japonisant fait référence à de nombreuses œuvres du compositeur. Cet endroit est un bel exemple de jardin qui a inspiré l’œuvre d’un musicien, mais aussi que la musique a inspiré. Cet article permet une réflexion sur le jardin, rarement évoqué, et attribue l’aménagement à Lucien Paré, paysagiste et horticulteur, issu de l’École d’horticulture de Versailles dont l’enseignement a fait l’objet de récentes études. La maison est distinguée par le label Maison des Illustres et la maison et le jardin sont classés au titre des monuments historiques depuis 2022.
Un panorama historique illustré des égouts parisiens aux Archives de Paris
Authors: Bouttier Ronan , Courtin Nicolas 
Published: September 2023

Les Archives de Paris ont collecté en 2018 un ensemble unique de documents graphiques relatifs aux égouts de la Capitale à la fin du xixe siècle. À côté de plans retraçant l’évolution du réseau depuis le xviie siècle, il s’agit surtout de vues en coupe de voies parisiennes. Ces dernières montrent autant la vie à l’air libre de la Capitale autour de 1900 que les différents équipements enterrés sous la voie publique (égouts, canaux, chemin de fer, gaz…). Ces plans et aquarelles ont servi de support à la valorisation du système d’assainissement de Paris lors de l’Exposition universelle de 1900, dans une démarche à la fois pédagogique et d’autosatisfaction.Cette contribution vise à apporter quelques éléments sur le contexte d’élaboration de ces documents et à comprendre les raisons de la très grande attention que les services municipaux leur ont portée – jusqu’à leur oubli quasi complet au xxie siècle. Récemment restaurés, ces documents de grand format ont été numérisés et peuvent désormais être à nouveau consultés.
Stroke prevention and intracranial hemorrhage risk in atrial fibrillation management: A mini review
Authors: Roychoudhury Rohon , Ma Shuangtao , Qian Chunqi 
Published: September 2023

Abstract
This mini-review examines the management of atrial fibrillation (AF) in patients at high risk of bleeding, with a focus on stroke prevention and intracranial hemorrhage risk. Anticoagulant therapy is commonly advised for AF patients, but it can elevate the risk of intracranial hemorrhage in certain individuals prone to bleeding. Two primary perspectives for managing high-risk patients are discussed: adhering to strict anticoagulation therapy or opting for alternative treatments like left atrial appendage closure (LAAC) or aspirin. The benefits and drawbacks of each approach are evaluated, emphasizing the importance of a personalized management plan based on patient risk profiles, comorbidities, and preferences. Ongoing research, including artificial intelligence, advances in LAAC devices, and combination therapies, is explored to enhance stroke prevention and minimize bleeding risk in AF management. A multidisciplinary approach and continuous investigation are vital to achieving better patient outcomes and overall care in this context.
A double-hit: End-stage renal disease patients suffer worse outcomes in intracerebral hemorrhage
Authors: Lui Aiden K. , Lin Fangyi , Uddin Anaz , Nolan Bridget , Clare Kevin , Nguyen Terry , Spirollari Eris , Feldstein Eric , Bornovski Yarden , Dominguez Jose , Coritsidis George , Gandhi Chirag D. , Al-Mufti Fawaz 
Published: September 2023

Abstract

BACKGROUND:
Intracerebral hemorrhage (ICH) carries significant morbidity and mortality. Previous single-center retrospective analysis suggests that end-stage renal disease (ESRD) is a risk factor for severe ICH and worse outcomes. This investigation aims to examine the impact of ESRD on ICH severity, complications, and outcomes using a multicenter national database.

METHODS:
The International Classification of Disease, Ninth and Tenth Revision Clinical Modification codes were used to query the National Inpatient Sample for patients with ICH and ESRD between 2010 and 2019. Primary endpoints were the functional outcome, length of stay (LOS), and in-hospital mortality. Multivariate variable regression models and a propensity-score matched analysis were established to analyze patient outcomes associated with baseline patient characteristics.

RESULTS:
We identified 211,266 patients with ICH, and among them, 7,864 (3.77%) patients had a concurrent diagnosis of ESRD. Patients with ESRD were younger (60.85 vs. 67.64, P < 0.01) and demonstrated increased ICH severity (0.78 vs. 0.77, P < 0.01). ESRD patients experienced higher rates of sepsis (15.9% vs. 6.15%, P < 0.01), acute myocardial infarction (8.05% vs. 3.65%, P < 0.01), and cardiac arrest (5.94% vs. 2.4%, P < 0.01). In addition, ESRD predicted poor discharge disposition (odds ratio [OR]: 2.385, 95% confidence interval [CI]: 2.227–2.555, P < 0.01), longer hospital LOS (OR: 1.629, 95% CI: 1.553–1.709, P < 0.01), and in-hospital mortality (OR: 2.786, 95% CI: 2.647–2.932, P < 0.01).

CONCLUSIONS:
This study utilizes a multicenter database to analyze the effect of ESRD on ICH outcomes. ESRD is a significant predictor of poor functional outcomes, in-hospital mortality, and prolonged stay in the ICH population.
A narrative review of retinal vascular parameters and the applications (Part I): Measuring methods
Authors: Gao Yuan , Xu Lijun , He Ning , Ding Yuchuan , Zhao Wenbo , Meng Tingting , Li Ming , Wu Jiaqi , Haddad Yazeed , Zhang Xuxiang , Ji Xunming 
Published: September 2023

Abstract
The retina is often used to evaluate the vascular health status of eyes and the whole body directly and noninvasively in vivo. Retinal vascular parameters included caliber, tortuosity and fractal dimension. These variables represent the density or geometric characteristics of the vascular network apart from reflecting structural changes in the retinal vessel system. Currently, these parameters are often used as indicators of retinal disease, cardiovascular and cerebrovascular disease. Advanced digital fundus photography apparatus and computer-assisted analysis techniques combined with artificial intelligence, make the quantitative calculation of these parameters easier, objective, and labor-saving.
A narrative review of retinal vascular parameters and the applications (Part II): Diagnosis in stroke
Authors: Gao Yuan , Xu Lijun , He Ning , Ding Yuchuan , Zhao Wenbo , Meng Tingting , Li Ming , Wu Jiaqi , Haddad Yazeed , Zhang Xuxiang , Ji Xunming 
Published: September 2023

Abstract
The retina, as an external extension of the diencephalon, can be directly, noninvasively observed by ocular fundus photography. Therefore, it offers a convenient and feasible mode to study nervous system diseases. Caliber, tortuosity, and fractal dimension, as three commonly used retinal vascular parameters, are not only the reflection of structural changes in the retinal microcirculation but also capture the branching pattern or density changes of the retinal microvascular network. Therefore, it contributes to better reflecting the subclinical pathological changes (e.g., lacunar stroke and small cerebral vascular disease) and predicting the risk of incident stroke and recurrent stroke.
Perception of Depressive Symptoms in Patients after Myocardial Infarction
Authors: Sharovsky Lilian Lopes , Romano Bellkiss Wilma , Franchini Ramires Jose Antonio 
Published: September 2023

Background:
The association between depressive symptoms and adverse outcomes in patients with coronary artery disease (CAD) is well recognized. However, few studies address the patient's perception of his physical and mental condition after a myocardial infarction (MI). The present study was designed to explore the subjective aspects of the psychological conditions in post-MI patients.

Method and Results:
A subject population of 8 male patients (age 59±5), selected by saturation sampling, with an average of 6 months post-MI, were submitted to an individual semi-structured interview and afterwards participated in 12 psychodynamic group sessions.

Conclusion:
There was a predominant non-acceptance of MI due to emotional barriers and this attitude has the potential to influence negatively the adherence to a comprehensive cardiovascular treatment, including pharmacological intervention for depression
Prenatal Sonographic Three-dimensional Virtual Organ Computer-assisted Analysis Thymic Volume Calculation May Predict Intrauterine Growth Restriction
Authors: Dogan Zeki , Guven Emine Seda Guvendag , Albayrak Mehmet , Guven Suleyman 
Published: September 2023

Background:
Intrauterine growth restriction (IUGR) refers to fetuses that are small for their gestational age. There is no effective test to predict this disease. The aim of our study is whether fetal three-dimensional (3D) ultrasonography (USG)-assisted thymus volume (TV) measurement predicts IUGR cases.

Methods:
Fetal 3D USG thymus measurement between 15 and 24 weeks of gestation was performed in a total of 100 women of reproductive age. Fetal TV was measured using the virtual organ computer-assisted analysis system program. All cases were followed up in terms of pregnancy complications until delivery.

Results:
IUGR was developed in six cases in total. In cases with IUGR, mean fetal TV was found to be statistically significantly lower than in healthy cases without it. When the fetal TV was taken as 0.1645, the sensitivity was calculated as 89.5% and the specificity as 50% for predicting IUGR. The use of low fetal volume parameters is a significant and good indicator for predicting IUGR according to the binary logistic regression analysis result.

Conclusion:
According to the results of this study, 3D fetal TV measurement may be used in routine second-trimester sonographic anomaly screening to predict the development of fetal IUGR. In this way, fetal mortality and morbidity caused by IUGR may be reduced.
Hematological Scoring System and its Correlation with Blood Culture, C-reactive Protein, and Micro-erythrocyte Sedimentation Rate in Early Diagnosis of Neonatal Sepsis
Authors: Amir Nawal , Ahmad Murad , Akhtar Kafil , Hassan Mohammad Jaseem 
Published: September 2023

BACKGROUND:
Neonatal sepsis is a major health problem in our country. The cause for most of the deaths is not a failure to treat the infection, instead, it is the failure to treat it on time. Sepsis is usually identified by a gold-standard blood culture test. However, there is a need for a simple and cost-effective diagnostic tool with quick results.

MATERIALS AND METHODS:
A total of 70 neonates with clinical suspicion of sepsis were included in our study. The hematological parameters such as total leukocyte count(TLC), absolute neutrophil count (ANC), platelet count, immature neutrophil count, immature to total neutrophil ratio (I:T), immature to mature neutrophil ratio (I:M), toxic granules, and cytoplasmic vacuolation in neutrophil were correlated with C-reactive protein (CRP), blood culture and micro-erythrocyte sedimentation rate (micro-ESR). The performance of these hematological parameters was evaluated with the help of hematological scoring system (HSS).

RESULTS:
Among the hematological parameters, TLC has high sensitivity (77.8%) and specificity (72.1%), ANC has the least sensitivity (44.4%) but the highest specificity (96.7%), platelet count has high sensitivity (88.9%) but low specificity (44.3%), I:T and I:M ratio have the highest sensitivity (88.9% both), specificity (71.1% and 88.5%, respectively) and negative predictive value (91.3% and 92.8% respectively). ANC and I:M ratios have the highest positive predictive value (89.3% and 82.5%, respectively) in predicting the early diagnosis of neonatal sepsis.

CONCLUSION:
HSS along with CRP and micro-ESR can be used as a screening tool in neonates with clinical suspicion of sepsis as they are simple to perform, and can be done even in rural parts of the country.
Role of Coagulation Parameters and Inflammatory Biomarkers in Coronavirus Disease 2019 Patients: A Demystifying Endeavor
Authors: Kumarguru B. N. , Sreegiri Sindhu , Swathi D. , Ramaswamy A. S. , Arathi C. A. 
Published: September 2023

BACKGROUND:
Coronavirus disease 2019 (COVID-19) globally known as COVID-19 is a heterogeneous disease caused by the severe acute respiratory syndrome coronavirus 2. COVID-19 patients having severe disease and are critically ill are more prone to have abnormal coagulation prolife. It may lead to thromboinflammation in severe conditions.

AIM:
The aim is to evaluate the utility of coagulation parameters and inflammatory biomarkers in COVID-19 patients in the study conducted for 6 months duration.

MATERIALS AND METHODS:
It was a retrospective observational study conducted from April 2021 to September 2021 in a rural tertiary care referral Institute. Available data of the baseline values of coagulation parameters (platelet count [PLC], prothrombin time [PT], international normalized ratio [INR], partial thromboplastin time [PTT] and D-dimer) and inflammatory markers (C-reactive protein [CRP], serum lactate dehydrogenase [LDH], and serum ferritin) were evaluated with respect to the clinical severity of the disease and also the survival status of COVID-19 patients.

RESULTS:
One hundred and fifty-five cases of COVID-19-positive patients were analyzed. PT, INR, PTT, D-dimer, CRP, LDH, and ferritin had higher mean in severe cases than the nonsevere cases. PLC had higher mean in the severe cases than the nonsevere cases. PT, INR, PTT, D-dimer, CRP, LDH and ferritin had higher mean in nonsurvivors than the survivors. PLC had lower mean in nonsurvivors than the survivors.

CONCLUSION:
Baseline values of PT, INR, PTT, D-dimer, LDH, and ferritin may be considered reliable indicators of severity of COVID-19 disease. Baseline values of D-dimer, LDH, and ferritin may be considered a reliable indicator of survival of patients suffering from COVID-19 infection.
Estimated Level of Plasma Micro RNA-210 in Beta Thalassemia Patients and Its Relation to Hemoglobin F Level and Disease Severity
Authors: Sharshera Homam M. , Maghraby Shereen M. El , Aglan Shaimaa A. , Mikhael Irene L. , Balbaa Ola A. 
Published: September 2023

BACKGROUND:
Beta-thalassemia is an autosomal recessive hereditary blood disorder occurs due to absent or diminished β-globin chains synthesis. The transformation from fetal to adult in globin synthesis is controlled by different mechanisms; one of those is BCL11A which is downregulated by microRNA-210 (miRNA-210). Therefore, this would lead to reactivation of fetal hemoglobin (HbF) production that improves anemia and reduces the needs for transfusion.

OBJECTIVE:
To study miRNA-210 in the plasma of beta thalassemia patients and its relation to HbF level and disease severity.

SUBJECTS AND METHODS:
The study was carried out on 50 individuals divided into three groups. Group A included 30 thalassemia major patients, Group B included 10 thalassemia intermedia patients, and Group C is 10 healthy volunteers as control. All individuals underwent to history taking, physical examination, and laboratory investigations, complete blood count, serum ferritin, hemoglobin electrophoresis, and measurement of miRNA-210 expression levels in plasma of peripheral blood samples by quantitative real-time polymerase chain reaction.

RESULTS:
Examination of miRNA-210 plasma level among different groups revealed no statistically significant association between control and thalassemia group or its subgroups (Major and intermedia) (P = 0.224, P = 0.116, and P = 0.734, respectively). Moreover, miRNA-210 was slightly higher in responders than nonresponders to hydroxyurea but did not reach significant level.

CONCLUSION:
miRNA-210 levels were not associated with increase in HbF levels in thalassemia patients.
Integrated care in cardiac intensive care unit for noncardiovascular complications in children after open-heart surgery: A comprehensive review
Authors: Shahzad Muhammad , Alheraish Yasser Abdulrhman , Beheri Reem Mohamed , Alarwan Khaled 
Published: September 2023

Abstract
Congenital heart defects (CHDs), the most common major birth defects, undergo effective surgical care in the last decade, enhancing survival. After heart surgery, mechanical, infectious, and noninfectious causes induce pediatric pulmonary problems. Necrotizing enterocolitis and feeding intolerance are frequent digestive issues. Diuretics relieve fluid excess, but early dialysis may help in cardiac intensive care unit (CICU) patients. Cumulative insulin dosages improve postoperative hyperglycemia. Noncardiac organ system problems are common in current pediatric cardiac intensive care units including seizures needing anti-epileptics. While, managing the patients in CICU, one must consider noncardiac organ system integrity and function.
Impact of introduction of a rounding checklist in a pediatric intensive care unit of a developing country: A quality improvement project
Authors: Abbas Awais , Aziz Faris Abdul , Siddiqui Naveed Ur Rehman , Hashwani Yasmin , Khan Iraj , Rasool Aniqa Abdul , Haque Anwar Ul , Abbas Qalab 
Published: September 2023

Abstract

Background:
Patients admitted to critical care need timely interventions after evaluating all clinical parameters. This study aims to assess the impact of the comprehensive rounding checklist on physician compliance and patient-related outcomes in a multidisciplinary pediatric intensive care unit (PICU).

Subjects and Methods:
This prospective observational study was conducted in two phases over period of 2 months at multidisciplinary PICU from Pakistan. A structured rounding checklist of 35 components encompassing patient care was introduced and implemented in the PICU. During the preimplementation phase, a nurse took notes of relevant patient clinical details missed by the physician during the round, included them in the rounding checklist. And during the implementation phase, the nurse actively intervened when a physician did not discuss a particular component during the round. All components discussed were check marked.

Results:
The checklist was completed for 812 rounds (162 patients) in preimplementation and 2348 rounds (590 patients) in the postimplementation phase. Most frequently missed components in the preimplementation phase were checking for surgical site infection (8.9%), discharge plan (7.5%), deep vein thrombosis (DVT) prophylaxis (7.3%), and ventilator-associated pneumonia bundles (7.0%). Whereas, during the postimplementation phase, resident teaching (8.0%), discharge plan (7.2%), and DVT prophylaxis (6.5%) were most frequently missed. Hospital length of stay decreased from 4.5 ± 3.7 to 4.1 ± 2.9 days (P = 0.05), and overall mortality decreased from 19% to 11.4% (P < 0.05).

Conclusions:
Introducing the checklist with a prompter, improved physician compliance and patient-related outcomes in our PICU.