bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alteration of Metabolic Profile During the Progression of Alzheimer’s Disease
Authors: Yu Wuhan , Li Xuebing , Han Ting-li , Yang Yang , Long Fei , Hu Cheng , Yu Weihua , Lü Yang 
Published: January 2023

Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that threatens the population health of older adults. However, the mechanisms of how altered metabolism involving in AD pathology are poorly understood. The aim of the study was to identify potential biomarkers of AD and discover metabolomic changes that produced during the progression of the disease. The Gas chromatography-mass spectrometry (GC-MS) was used to measure the concentrations of serum metabolites in a cohort of subjects with AD (n = 88) and cognitively normal control (CN) (n = 85). The patients were classified as very mild, mild, moderate, and severe. Serum metabolic profiles were analyzed by multivariate and univariate approaches. The least absolute shrinkage and selection operator (LASSO) logistic regression was applied to identify potential biomarkers of AD. Biofunctional enrichment analysis was performed using the Kyoto Encyclopedia of Genes and Genomes. Our results revealed considerable separation between the AD and CN. Six metabolites were identified as potential biomarkers of AD (AUC > 0.85), and the diagnostic model of three metabolites could predict the risk for AD with high accuracy (AUC = 0.984). The metabolic enrichment analysis revealed that carbohydrate metabolism deficiency and disturbance of amino acids, fatty acids, and lipids metabolism are involved in AD progression. Especially, pathway analysis highlighted that l − glutamate participated in four crucial nervous system pathways (including GABAergic synapse, glutamatergic synapse, retrograde endocannabinoid signaling and synaptic vesicle cycle). Carbohydrate metabolism deficiency, amino acids dysregulation, fatty acids and lipids metabolism disorders were pivotal events in AD progression. Our study may provide novel insights into the role of metabolic disorders in AD pathogenesis and identify new markers for AD diagnosis.
Agro-ecological characteristics and gender gap in cereal productivity: evidence from small households in Burkina Faso
Authors: KY Habi 
Published: January 2023

Abstract
This paper analyzes the impact of agro-ecological partitioning on the gender gap in cereal productivity in Burkina Faso. The pooled OLS regression method and an extension of the Blinder–Oaxaca decomposition are used to estimate the effect of agro-ecological division on the gender gap in cereal productivity. The results show that women have 12.4% lower yields than men, and there is a 16.28% increase in the overall gap in the three environmentally less advantaged regions. A detailed analysis indicates that the gender effect is not significant in the region with high agricultural potentialities, whereas it is significant in the ecologically less advantaged regions. Considering the sample of household heads, we find that the Sahelian zone contributes to reducing the effect of agro-ecological characteristics on the yield gap. This result suggests that decision-making power within the household would allow women producers to improve their yields and close the gender gap. To reduce the gender gap in cereal productivity, policymakers should consider regional agro-ecological potentialities and women empowerment.
Clinical trial registration
Not applicable
JEL codes: J16; D24; C49
Environmental-related technologies and carbon neutrality challenges in emerging economies? A case study of China
Authors: Abbas Jaffar , Balsalobre-Lorente Daniel , Aljuaid Mohammed 
Published: January 2023

Abstract
This study provides new evidence for an unclear link between international cooperation (IC) and environmental-related technologies (ERT) with carbon neutrality (CN) in China. This research contributes to environmental economics literature by opening a new door for economic growth, fertility rate, environmental taxes, IC, and ERT from 1990 to 2020. Considering the sustainability initiatives taken by China, it is crucial to examine the mentioned factors' role in carbon neutrality. Therefore, we employed advanced techniques to investigate the study’s objectives. Estimated results show the harmful impact of economic progress, IC, and ERT on CN. Moreover, fertility rate and environmental taxes help out in emissions reduction. In addition, this study uses Breitung and Candelon causality test and supports the uni-directional association between economic progress to emissions and emissions to fertility rate in China. However, this study also proposes imperative policies to achieve the carbon neutrality target.
JEL Codes: O14, J13, O44, H23.
Heterologous booster vaccines reduce severity and mortality in COVID-19 during BA.2 and BA.4/BA.5 omicron predominance in Thailand
Authors: Intawong Kannikar , Chariyalertsak Suwat , Chalom Kittipan , Wonghirundecha Thanachol , Kowatcharakul Woravut , Thongprachum Aksara , Chotirosniramit Narain , Noppakun Kajohnsak , Khwanngern Krit , Teacharak Worachet , Piamanant Prapon , Khammawan Pimpinan , Iamsirithaworng Sopon 
Published: January 2023

Abstract

Background: The COVID-19 pandemic has evolved quickly, with variants of concern resulting in the need to offer booster vaccinations. Unfortunately, the booster uptake has been slow and vaccine response has shown to wane over time. Therefore, it’s critical to evaluate the role of vaccinations on outcomes with newer sub-lineages of omicron.
Methods: Utilising a Hospital Information System established in Chiang Mai, Thailand, we conducted a cohort study by linking patient-level data of laboratory-confirmed COVID-19 cases to the national immunization records, during BA.2 and BA.4/BA.5 predominance.
Results: In adjusted cox-proportional hazard models, BA.4/BA.5 was not associated with more severe COVID-19 outcomes or deaths as compared to BA.2. Risk of severe outcomes and deaths were significantly reduced with third (87% and 95%) and fourth (88% and 95%) dose vaccination, while events were not observed with a fifth dose. Across the regimens, vaccination within 14-90 days prior showed the highest level of protection. All the vaccine types used for boosting in Thailand offered similar protection against severe COVID-19.
Conclusions:Boosters provide high level of protection against severe COVID-19 outcomes and deaths with newer omicron sub-lineages. Booster campaigns should focus on improving coverage utilising all available vaccines to ensure optimal protection.
An overview on density peaks clustering
Authors: Wei Xiuxi , Peng Maosong , Huang Huajuan 
Published: January 2023

AbstractDensity Peaks Clustering (DPC) algorithm is a new algorithm based on density clustering analysis, which can quickly obtain the cluster centers by drawing the decision diagram by using the calculation of local density and relative distance. Without prior knowledge and iteration, the parameters and structure are simple and easy to implement. Since it was proposed in 2014, it has attracted a large number of researchers to explore experiments and improve applications in recent years. In this paper, we first analyze the theory of DPC and its performance advantages and disadvantages. Secondly, it summarizes the improvement of DPC in recent years, analyzes the improvement effect, and shows it with experimental data. Finally, the related application research of DPC in different fields is introduced. At the same time, we summarize and prospect the improvement and development of DPC.
Characterization of Hemodialysis Fistulas Experienced Abrupt Thrombosis and Determination of a Proper Follow-up Protocol: A Retrospective Cohort Study and an IR’s Prospective
Authors: Chen Matt Chiung-Yu 
Published: January 2023

Abstract
Background
Abrupt thrombosis is a form of thrombosis that occurs unexpectedly and without being preceded by hemodialysis fistula (AVF) dysfunction during dialysis. We found that AVFs with a history of abrupt thrombosis (abtAVF) appeared to have more episodes of thrombosis and required more frequent interventions than those without such history. Therefore, we sought to characterize the abtAVFs and examined our follow-up protocols to determine which one is optimal.
Methods
We performed a retrospective cohort study using routinely collected data. The thrombosis rate, AVF loss rate, thrombosis-free primary patency, and secondary patency were calculated. Additionally, the restenosis rates of the AVFs under the follow-up protocol/sub-protocols and the abtAVFs were determined.
Results
The thrombosis rate, procedure rate, AVF loss rate, thrombosis-free primary patency, and secondary patency of the abtAVFs were 0.237/pt-yr, 2.702/pt-yr, 0.027/pt-yr, 78.3%, and 96.0%, respectively. The restenosis rate for AVFs in the abtAVF group and the angiographic follow-up sub-protocol were similar. However, the abtAVF group had a significantly higher thrombosis rate and AVF loss rate than AVFs without a history of abrupt thrombosis (n-abtAVF). The lowest thrombosis rate was observed for n-abtAVFs, followed up periodically under the outpatient or angiographic sub-protocols.
Conclusions
AVFs with a history of abrupt thrombosis had a high restenosis rate, and periodic angiographic follow-up with a mean interval of 103.5 days was presumed appropriate. For selected populations, such as salvage-challenging AVFs, periodic outpatient or angiographic follow-up was mandatory to extend their usable lives for hemodialysis.
HHV-8 status in oral squamous cell carcinoma tissues in a group of Sri Lankan male patients
Authors: Perera Manosha Lakmali 
Published: January 2023

Abstract
Head and neck cancers (HNSCCs) are notable as a poignant public health menace and rank as the 8th most common cancer type according to a 2020 global estimation. Oral squamous cell carcinoma (OSCC) accounts for 90–95% of oral malignancies in most countries. Moreover, oral cancer as well as Kaposi’s sarcoma-associated herpes virus (KSHV) prevalence demonstrates geographic and population specificity. Immunosuppression in oral cancer patients could trigger the multiplication and transmission of oncogenic γ-herpes viruses in oral cancer patients. The objective of this study was to find out the HHV-8 status in oral squamous cell carcinoma tissues in a group of Sri Lankan male patients. Incisional biopsies of cases and excisional biopsies of controls collected, transported, stored, and dispatched as frozen tissues at -800 C. Then, DNA extracted from frozen specimens using Gentra Puregene Tissue kit (Qiagen, Germany), solid tissue protocol according to the manufacturer’s instructions. Subsequently, real-time PCR was performed to detect HHV 8 in these OSCC cases and FEP controls. HHV- 8 was not detected in 22 OSCC cases and 29 FEP control samples. Thus, HHV-8 viral infections may not be a problem in oral cancer patients in Sri Lanka.
Brain-behavior analysis of transcranial direct current stimulation effects on a complex surgical motor task
Authors: Walia Pushpinder , Fu Yaoyu , Norfleet Jack , Schwaitzberg Steven D. , Intes Xavier , De Suvranu , Cavuoto Lora , Dutta Anirban 
Published: January 2023

Abstract
Transcranial direct current stimulation (tDCS) has been shown to facilitate surgical training and performance when compared to sham tDCS; however, the potency may be improved by selecting appropriate brain targets based on neuroimaging and mechanistic insights. Published studies have shown the feasibility of portable brain imaging in conjunction with tDCS during Fundamentals of Laparoscopic Surgery (FLS) tasks for concurrently monitoring the cortical activations via functional near-infrared spectroscopy (fNIRS). Then, fNIRS can be combined with electroencephalogram (EEG) where EEG band power changes have been shown to correspond to the changes in oxyhemoglobin (HbO) concentration, found from the fNIRS. In principal accordance with these prior works, our current study aimed to investigate multi-modal imaging of the brain response to cerebellar (CER) and ventrolateral prefrontal cortex (PFC) tDCS that may facilitate the most complex FLS suturing with intracorporal knot tying task. Our healthy human study on twelve novices (age: 22-28 years, 2 males, 1 female with left-hand dominance) from medical/premedical backgrounds aimed for mechanistic insights from neuroimaging brain areas that are related to error-based learning – one of the basic skill acquisition mechanisms. We found that right CER tDCS of the posterior lobe facilitated a statistically significant (q<0.05) brain response at the bilateral prefrontal areas at the start of the FLS task that was higher than sham tDCS. Also, right CER tDCS significantly (p<0.05) improved FLS score when compared to sham tDCS. In contrast, left PFC tDCS failed to facilitate a significant brain response and FLS performance improvement. Moreover, right CER tDCS facilitated activation of the bilateral prefrontal brain areas related to FLS performance improvement provided mechanistic insights into the CER tDCS effects. The mechanistic insights motivated future investigation of CER tDCS effects on the error-related perception action coupling based on directed functional connectivity studies.
First record of Ozius tuberculosus H. Milne Edwards (Crustacea: Decapoda: Brachyura) from the East Coast of India
Authors: Banerjee Someah , SREE CHEMMENCHERI RAMAKRISHNAN 
Published: January 2023

Abstract
The diversity of marine brachyuran crabs along India's east coast has been investigated extensively. This study deals with the widespread distribution of Ozius tuberculosus H. Milne Edwards'- 1834 species in India’s eastern coast of Visakhapatnam. Currently, the distribution of O. tuberculosus, covers the Maharashtra, Karnataka, Kerala, the Lakshadweep Islands, and the Andaman and Nicobar Islands, which herein we report the new record from Yarada beach (17.6548 N, 83.2697 E), Visakhapatnam, Andhra Pradesh as well as east coast of India, additionally, we provided new details regarding the geographic range of this species in India and throughout the world, and a taxonomic description is also given.
Theoretical Investigation of Adjustable Plasmonic Modes in Graphene- based Heterostructures in THz Range: Transfer Matrix Method
Authors: Heydari Mohammad Bagher , Karimipour Majid , Shirkolaei Morteza Mohammadi 
Published: January 2023

Abstract
In this article, we investigate the characteristics of the reflected beam from graphene-based hexagonal Boron Nitride (hBN) heterostructure. Analytical expressions are obtained for calculating the reflection characteristics. A large value of the reflected group delay is reported in the lower Reststrahlen band; therefore, this frequency range is chosen to be studied. To show the tunability of the proposed structure, the variations of the reflected beam as a function of frequency are depicted and studied for various values of chemical potential. Our results indicate a large value of the reflected group delay, i.e. 𝝉r = 15.3 ps, at the frequency of 24.9 THz. Moreover, we will show that the thickness of graphene sheets, the hBN medium, and the SiO2 layer can change the quality of the reflected beam more effectively. The authors believe that the presented study can be utilized for the design of optical delay structures in the mid-infrared region.
A study of diabetic patients' awareness about diabetic foot care to prevent complications.
Authors: Aldammad Seba , Hammoud Taghrid 
Published: January 2023

Abstract
Introduction

Diabetic patient’s knowledge of how to take care of their feet plays an important role in preventing these complications with a reduced social, medical and economic burden of its consequences including foot ulcers and amputation. This study aims to assess the knowledge, attitude and practices that affects the diabetic foot ulcers.

Aim

To assess the knowledge, attitude, and practices regarding diabetic foot care among diabetic patients.

Methods

It is a cross-sectional study conducted from January 25, 2022 to March 15, 2022 at Diabetic clinic, Damascus Hospital. Non‐randomized, non‐probability convenience sampling technique was used to collect data from 249 patients by using a validated and confidential questionnaire.

Results

The mean age of patients was 54.19 years with 54% male and 46% female patients. Majority of patients had diabetes for more than 10 years. and most of them had Type 2 Diabetes, also more than half of the patients stopped their education in middle school. An important percentage of having a family history of Diabetes was found. In addition, many of the patients take oral hypoglycemic medications with regulatory drugs for Diabetes. More than half of these patients had peripheral neuropathy. The mean scores for knowledge, attitude, and practice were 8.74, 2.97, and 7.95, respectively, all statistically significant.

Conclusion

Our study population has sufficient knowledge about diabetes and its foot complication, and they had a positive attitude towards its management. However, they were lagging in the practices required for diabetic foot management.
A Case report of atypical preeclampsia with severity criteria for hydatidiform complete mole
Authors: Pérez-Nieto Orlando Rubén , Herrera-Venegas Christian Alberto , Pozos-Cortés Karen Pamela , Flores-Ramírez Raymundo , Ugalde-Real Jesús Salvador , Argüello-Bolaños Jardiel , Phinder-Puente Marian Elizabeth , Zamarrón-López Éder Iván , Deloya-Tomas Ernesto 
Published: January 2023

Abstract
Background: Preeclampsia is defined as the elevation of blood pressure levels and any of the following severity criteria: proteinuria, thrombocytopenia, elevation of creatinine in the absence of another renal pathology, elevation of transaminases, pulmonary oedema or neurological symptoms. This after 20 weeks of gestation in a previously normotensive patient, however, cases of preeclampsia have been described in patients with less than 20 weeks of gestation associated with molar pregnancy.
Case description: A 26-year-old woman, with 14.1 weeks of gestation, is admitted with in the lower extremities, facial oedema, holocranial headache, nausea, epigastralgy, phosphenes and photophobia, with double-length uterine fundus for gestational age and ultrasound. obstetrician who showed image in snowflake, without foetus and annexes with multiple thecal-lutein cysts. Atypical preeclampsia was identified with severity data for complete hydatidiform mole.
Conclusion. Given the possibility of serious complications that may endanger the life of the maternal-foetal binomial, atypical forms of presentation of preeclampsia should be suspected.
New Strategies in the Treatment of Plasmodium berghei Based on
Nanoparticles: A Systematic Review
Authors: Cheraghipour Kourosh , Shakib Pegah , Marzban Abdolrazagh , Mardanshah Omid , Fallahi Shirzad , Khan Israr Ali , Azarhazin Mohammad 
Published: January 2023

Background:
Drug resistance is a current issue affecting parasites caused by Plasmodium.
Therefore, researchers have expanded their studies on nanoparticles to find new and effective
drugs that can treat drug-resistant strains. The present study systematically investigates the effect of
different nanoparticles, including metal, polymer, and lipid nanoparticles, on Plasmodium berghei.

Methods:
In this study, English-language online literature was obtained from the databases Science
Direct, PubMed, Scopus, Ovid, and Cochrane to conduct a systematic review. In the search, we used
the keywords: (Plasmodium Berghei) AND (Malaria) AND (Parasitemia) AND (antimalarial activity)
AND (nanoparticles) AND (Solid lipid NPS) AND (Nano lipid carriers) AND (Artemether)
AND (Chloroquine) AND (intraperitoneal) AND (in vivo). Initially, a total of 160 studies were retrieved
from the search. After removing duplicates, 80 studies remained. After reviewing the title
and abstract of each study, 45 unrelated studies were eliminated.

Results:
The remaining 35 studies were thoroughly reviewed using the full texts. The final result
was 21 studies that met the inclusion/exclusion criteria.

Conclusion:
Using these findings, we can conclude that various nanoparticles possess antiparasitic
effects that may be applied to emerging and drug-resistant parasites. Together, these findings suggest
that nanostructures may be used to design antiparasitic drugs that are effective against Plasmodium
berghei.
Synthesis and Antibacterial Activity of Erythromycin 9-Acylhydrazone
Derivates
Authors: Cao Zhiling , Zheng Wei , Huang Maolong , Yao Xinran , Zhu Wenrong , Sheng Lanjun , Pan Zaixiu , Bian Yuzong , Zhang Tian , Zhu Cong 
Published: January 2023

Background:
Some species of Marine bacteria pose great risks to human and mariculture organisms. Meanwhile, Vibrio harveyi and Vibrio parahaemolyticus strains have acquired resistance to many antibiotics.

Objective:
A novel series of erythromycin 9-acylhydrazone derivatives were synthesized and evaluated for their in vitro antibacterial activity against marine pathogens.

Methods:
The site-selective N-acylation of erythromycin hydrazone was achieved using acid chloride/triethylamine in methanol as the reaction system. All the synthesized target compounds were evaluated for their antibacterial activity by determination of minimum inhibitory concentrations (MICs) using the broth microdilution method.

Results:
All the tested acylhydrazone compounds showed moderate to high activity with MIC value 0.125-1 μg/mL against Vibrio parahaemolyticus and Vibrio harveyi.

Conclusion:
The introduction of the acylhydrazone moiety at the C-9 position of erythromycin improved its activity against the above-mentioned marine bacteria strains.
MiR-223-3p Aggravates Ocular Inflammation in Sjögren’s Syndrome
Authors: Qi Xuan , Wang Ronghua , Jin Lu , Tian Yu , Jin Hongtao , Han Yuxiang , Sun Chao , Ding Meng , Guo Huifang 
Published: January 2023

Background and Objectives:
Sjogren’s syndrome (SS) is a chronic autoimmune disease,
particularly involving the lacrimal and salivary glands, with dryness as the main symptom. To date, the
pathogenesis of SS is not fully understood. Recently, numerous miRNAs were implicated in SS etiology
and pathogenesis.

Methods:
Ocular wash was collected from SS patients and healthy controls. INF-γ-treated salivary
gland epithelial cells (SGECs) were utilized as SS in vitro models. Expressions of miR-223-3p and
inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) in ocular wash specimens and cells were measured
by RT-qPCR assay and western blot analysis, respectively. ELISA assay was exploited to detect IL-6,
IL-12, and TNF-γ levels. CCK-8, flow cytometry, and western blot assay were exploited to determine
cell viability, apoptosis, and apoptosis-related protein levels.

Results:
ITPR3 was a direct downstream gene of miR-223-3p and negatively modulated by miR-223-
3p. MiR-223-3p increased while ITPR3 decreased in samples from SS patients and INF-γ-induced
SGECs. miR-223-3p knockdown facilitated INF-γ-induced SGECs cell viability and restrained apoptosis
and inflammation response through the NF-κB pathway.

Conclusion:
MiRNA-223-3p is implicated in the process of SS initiation and development. It may become
one of the targets for the treatment of SS in the future, as well as a possible indicator for clinical
monitoring of disease activity.