bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rice straw anaerobic digestion enhancement through bioaugmentation: effect on the microbial community
Authors: Pérez Annerys Carabeo , López María Isabel Sánchez , Rivera Gilda Guerra , Henderson Deborah , Jiménez Janet 
Published: June 2023

Abstract
The degradation of agricultural residues by anaerobic digestion and their bioconversion to methane is still hampered by the search for pretreatment strategies due to the lignocellulosic content that limits the efficiency of the process. Adding an enriched microbial consortium could be an alternative for the biological treatment of lignocellulosic biomass. During the degradation process, it is necessary to study the dynamics and structure of the microbial community. The objective of this study was to evaluate the addition of an enriched microbial consortium, and its effect on the methane-producing prokaryotic community during the anaerobic digestion of rice straw. The consortium was characterized by diversity, microbial community dynamics, and taxonomic identification. The rice straw anaerobic digestion was bioaugmented using the microbial consortium in 10 L semi-continuous stirred tank reactors (35 ± 2°C) for 70 days of operation at increasing organic loading rates up to 1.8 g VS L-1 d-1. Relative to the control reactor, higher and more stable methane production was obtained with the biological treatment strategy. The metagenomic method allowed identification down to the genus and species level of microbial consortium and the prokaryotic community within the reactors. From the knowledge of the diversity and dynamics of the microbial community, possible preferential metabolic pathways were presumed. The enhanced anaerobic degradation of rice straw by the microbial consortium and its effect on the methane-producing microbial community demonstrated that it could be used as a bioproduct for the treatment of agricultural waste for energy purposes.
Straintronics in Phosphorene: Tensile vs Shear Strains and Their Combinations for Manipulating the Band Gap
Authors: Solomenko Anastasiia , Sahalianov Ihor , Radchenko Taras , Tatarenko Valentyn 
Published: June 2023

Abstract
We study the effects of the uniaxial tensile strain and shear deformation as well as their combinations on the electronic properties of single-layer black phosphorene. The evolutions of the strain-dependent band gap are obtained using the numerical calculations within the tight-binding (TB) model as well as the first-principles (DFT) simulations and compared with previous findings. The TB-model-based findings show that the band gap of the strain-free phosphorene agrees with the experimental value and linearly depends on both stretching and shearing: increases (decreases) as the stretching increases (decreases), whereas gradually decreases with increasing the shear. A linear dependence is less or more similar as compared to that obtained from the ab initio simulations for shear strain, however disagrees with a non-monotonic behaviour from the DFT-based calculations for tensile strain. Possible reasons for the discrepancy are discussed. In case of a combined deformation, when both strain types (tensile/compression + shear) are loaded simultaneously, their mutual influence extends the realizable band gap range: from zero up to the values respective to the wide-band-gap semiconductors. At a switched-on combined strain, the semiconductor–semimetal phase transition in the phosphorene is reachable at a weaker (strictly non-destructive) strain, which contributes to progress in fundamental and breakthroughs.
Patient experiences and perspectives of health service access for carpal tunnel syndrome in Aotearoa New Zealand: A Normalisation Process Theory-informed qualitative study
Authors: Buhler Miranda , Atmore Carol , Perry Meredith , Crengle Sue , Norris Pauline , Baxter G. David 
Published: June 2023

Abstract
Background Early access to care for carpal tunnel syndrome (CTS) can avoid higher rates of surgery and permanent harm yet is often delayed, particularly for populations more likely to underutilise care.
Objective We sought to explore patient experiences and perspectives of health service access for CTS to inform an equity-focussed co-design of a health service for improving early care access.
Methods In this Normalisation Process Theory (NPT)-informed qualitative study we conducted semistructured in-depth interviews with 19 adults with experience of CTS. Recruitment prioritised New Zealand Māori, Pasifika, low-income, and rural populations. Data were analysed using deductive then inductive thematic analysis.
Results We identified five major themes: 1) the ‘Significant Impact’ of the sense-making and relational work to understand the condition, deciding when to get care, compelling clinicians to provide care, and garnering help from others; 2) ‘Waiting and Paying’ – the enacting, relational, and appraising work to avoid long wait times unless paying privately, particularly where quality of care was low, employment relations poor, or injury compensation processes faltered; 3) circumstances of ‘Occupation and Onset’ whereby the burden of proof to relate onset of CT symptoms to occupation created excessive relational and enacting work; 4) the ‘Information Scarcity’ of good information and the high relational and appraising work associated with using online resources; 5) ‘Negotiating Telehealth Perspectives’ with telehealth valued if it meant earlier access for all despite the challenges it held for many.
Conclusion Quality, culturally and linguistically responsive information and communication from clinicians and health services will improve equitable early access to CTS care including realising the potential of telehealth modes of care. Policy changes that reduce individual burden of proof in injury compensation claims processes, enable time off work to attend health appointments, and increase public funding for surgical resources would improve early access to CTS care particularly for Māori and Pacific populations and those in small and rural workplaces. NPT is valuable for understanding where opportunities lie to reduce the work involved in accessing health care for populations more likely to underutilise care.
Description of chest pain patients in the Emergency Department at Sheikh Khalifa Medical City Ajman
Authors: Fouda Ghada , Vallabh Kamil , Elbahrawy Magda 
Published: June 2023

Abstract
results
Mean age of the studied population was 49.22 ± 12.65, most of the studied population were males, Male to female ratio was 2:1, mode of transport was mainly by Walking 94 (47%), private vehicle 50 (25%) and by ambulance 31(15.5%). Majority of patients were given triage 3 (moderate pain severity) 156 (78%), mean heart rate was 87.56 ± 17.97. In the 200 study population 103 were diagnosed as nonspecific chest pain 103 (51.5%), 27 (13.5%) were musculoskeletal chest pain. We found that 26 patients (13%) suffered from acute myocardial infarction (18 STEMI and 8 NSTEMI). Regarding the 18 patients with STEMI 15 (83.3%) were males and 3 (16.7%) were females, 12 sent for PCI and 6 for thrombolysis. Admitted patients were 40 (65%) with different diagnoses. Identifying patients with chest pain who have acute coronary syndrome (ACS) presents a challenge to ED physicians.
Validity and reliability of My Jump 2 app for estimating maximum height in counter-movement jump according to new method
Authors: Murawa Michal , Krakowiak Waldemar , Kabacinski Jaroslaw 
Published: June 2023

Abstract
The study aimed to determine the validity of My Jump 2 app compared to the force platform, and the reliability of this measurement tool for estimating the maximum height (MH) in the counter-movement jump (CMJ). Twenty-one untrained male students (age: 21.0 ± 1.9 years) participated in the study. The MH was estimated based on: (1) the displacement of the jumper’s center of mass (force platform), (2) the displacement time (DT) of the reflective marker stuck on the jumper’s sacrum according to the new concept and the flight time (FT) of the jumper (smartphone with My Jump 2 app), and (3) displacement of the reflective marker stuck on the jumper’s sacrum (mo-cap system). The analysis included intraclass correlation coefficient (ICC), Pearson correlation coefficient (r), Bland-Altman systematic bias and Cronbach’s alpha (α). Assessment of the concurrent validity showed a poor agreement (ICC = 0.362; bias = 12.4 cm) at r = 0.849 between the My Jump 2 app for FT and force platform (p < 0.001), a good agreement (ICC = 0.858; bias = -0.3 cm) at r = 0.763 between the My Jump 2 app for DT and force platform (p < 0.001) and an excellent agreement (ICC = 0.955; bias = -0.4 cm) at r = 0.913 between the mo-cap system and force platform (p < 0.001). The α values (> 0.9) indicated a very good reliability of all measurement tools. Findings revealed a high accuracy of the MH estimation method in CMJ based on the displacement of the marker stuck on the sacrum using the My Jump 2 app and mo-cap system.
Computational Exploration of Lung Function Genetics Across Populations via Public GWAS Data Integration
Authors: Zainab Afeefa , Anzawa Hayato , Kinoshita Kengo 
Published: June 2023

Abstract
Background
Chronic obstructive pulmonary disorder (COPD) is a highly prevalent disease, making it a leading cause of death worldwide. Several GWAS have been performed across multiple populations to measure lung function and identify loci associated with COPD. Population-specific GWAS shows that every population has a different ancestral genetic composition for the same disease in different populations. To analyze trans-ethnic genetics, GWAS meta-analysis is the commonly used method; however, meta-analysis has some limitations in terms of genetic heterogeneity when used for cross-population GWAS analysis, even though transethnic analyses are becoming increasingly important for personalized medicine in each population. In this study, we proposed a transethnic linkage disequilibrium LD analysis to identify common and unique functional variants in different population cohorts.
Methods
Lung function measurement is used as an indicator for the risk prediction of COPD; therefore, we used lung function GWAS data from two populations. The results from the Japanese and European population GWAS for lung function were re-evaluated using a trans-ethnic LD approach.
Results
This study identified nine novel independent significant single nucleotide variants SNVs and four lead SNVs in three genomic risk loci in the Japanese GWAS, whereas five novel lead SNVs and 17 novel independent significant SNPs were identified in 21 genomic risk loci in the European population. Comparative analysis revealed 28 genes that were similar in the prioritized gene lists of both populations. We also performed a meta-analysis-based post-GWAS analysis that identified 18 common genes in both populations less frequently than in our approach. Our approach identified significant novel associations and genes that have not been previously reported or were missed in the meta-analysis.
Conclusions
This study proposes a trans-ethnic LD approach for cross-population GWAS analysis that will help understand genetic diversity among different populations and identify generalized and population-specific treatment and diagnostic options.
Appropriate use of triazolam in elderly patients considering a quantitative benefit-risk assessment based on real-world data with a modeling and simulation approach
Authors: Okada Akira , Sera Shoji , Nagai Naomi 
Published: June 2023

Abstract

Background
Triazolam is a typical drug commonly used in the elderly; however, there have been concerns about its adverse events resulting from age-related changes in physiological function anddrug interactions with concomitant drugs. Thus, updated information contributing to the appropriate use based on the latest pharmacokinetic and post-marketing surveillance methods, is needed. In this study, we evaluated the appropriate use of triazolam in the elderly by integrating real-world data with a modeling and simulation approach.
Methods
The occurrence risk of adverse events in the elderly was evaluated using the spontaneous adverse event reporting regulatory databases from Japan and the United States. Information on drug concentrations and reactions was extracted from previous publications to estimated the threshold for plasma triazolam concentrations that cause adverse events.. The pharmacokinetic/pharmacodynamic (PK/PD) model was then constructed, and the dose and administration were evaluated in various situations anticipated in medical practice.
Results
Among all prescriptions, 25.4% were prescribed to individuals aged 80 years or above, and 51.8% were for those aged 70 years or above. A majority of cases involved CYP3A-metabolized drug combinations, accounting for 85.6%. Elderly individuals were at a higher risk of developing delirium and fall-fracture. Based on the constructed PK/PD model, the risk of adverse events increased when the plasma concentration of triazolam exceeded the calculated threshold of 0.44 µg/mL at approximately 6 hours after administration. Administering 0.125 mg of triazolam, which is half the approved dose for the elderly in Japan, was deemed appropriate. Moreover, there was a substantial risk of adverse events even at a dosage of 0.0625 mg in combination with a moderate or strong inhibitor of cytochrome P450 3A.
Conclusion
Analysis by integrating large-scale databases and existing research publications on PK/PD can practically contribute to the optimization of triazolam drug therapy for the elderly in the daily clinical setting.
Physical activity and depression during the COVID-19 pandemic in Nigeria: Does age and gender make a difference?
Authors: Muomah Rosemary C. , Chukwuorji JohnBosco C. , Nwonyi Sampson K. , Tay Doris A. , Joachim Dale , Malete Leapetswe , Adamba Clement , Nyawornota Vida Korleki , Nyanynofio Oscar , Donkor Samuel Kofi , Ocansey Reginald 
Published: June 2023

Abstract

Background
There is overwhelming evidence indicating that depression may be reduced by physical activity (PA) but studies in lower- and middle-income countries and those that involved data at higher physical activity doses were underrepresented. The current study investigated the associations between PA levels (vigorous, moderate, walking and sitting) and depression, and tested whether age and gender moderates the link between PA and depression during the COVID-19 pandemic.
Method
Participants were 857 adults (51.0% women; aged 18–69, mean age = 29.71, SD = 10.84 years) who completed an online survey as part of the General Health, Speech and Physical Activity Relationship Assessment Study in Nigeria. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) while depression was measured using the Patient Health Questionnaire (PHQ-9).
Results
Results of Hayes PROCESS macro indicated that those who engaged in vigorous PA reported lower levels of depression. Sitting, walking and moderate PA were not significantly associated with depressive symptoms. Older participants reported less symptoms of depression. Women had higher depressive symptoms compared to men. The interactions of age and gender with the PA levels were not significant, which showed that age and gender did not moderate the relationships of PA and depression.
Conclusion
Health practitioners should encourage people to engage in vigorous PA in order to reduce levels of depression and improve mental health in the general population.
Neuroinflammatory and Metabolomic Temporal Dynamics Following Wood Smoke Inhalation
Authors: Scieszka David , Jin Yan , Noor Shahani , Barr Ed , Garcia Marcus , Begay Jessica , Herbert Guy , Hunter Russell P , Bhaskar Kiran , Kumar Rahul , Gullapalli Rama , Bolt Alicia , McCormick Mark A. , Bleske Barry , Gu Haiwei , Campen Matthew 
Published: June 2023

Abstract
Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phenotypes. To address the longevity of such outcomes, the present study examined the neuroinflammatory and metabolomic temporal dynamics after inhalation exposures from biomass-derived smoke. 2-month-old female C57BL/6J mice were exposed to wood smoke every other day for two weeks at an average exposure concentration of 0.5mg/m3. Subsequent serial euthanasia occurred at 1-, 3-, 7-, 14-, and 28-days post-exposure. Flow cytometry of right hemispheres revealed two endothelial populations of PECAM (CD31), high and medium expressors, with wood smoke inhalation causing an increased proportion of PECAMHi. These populations of PECAMHi and PECAMMed were associated with an anti-inflammatory and pro-inflammatory response, respectively, and their inflammatory profiles were largely resolved by the 28-day mark. However, activated microglial populations (CD11b+/CD45low) remained higher in wood smoke-exposed mice than controls at day 28. Infiltrating neutrophil populations decreased to levels below controls by day 28. However, the MHC-II expression of the peripheral immune infiltrate remained high, and the population of neutrophils retained an increased expression of CD45, Ly6C, and MHC-II. Utilizing an unbiased approach examining the metabolomic alterations, we observed notable hippocampal perturbations in neurotransmitter and signaling molecules like glutamate, quinolinic acid, and 5-α-dihydroprogesterone. Utilizing a targeted panel designed to explore the aging-associated NAD+ metabolic pathway, wood smoke exposure drove fluctuations and compensations across the 28-day time course, ending with decreased hippocampal NAD+ abundance at day 28. Summarily, these results indicate a highly dynamic neuroinflammatory environment, with potential resolution extending past 28 days, the implications of which may include long-term behavioral changes, systemic and neurological sequalae directly associated wtith wildfire smoke exposure.
Discovery of N6-methyladenosine modification regulators and their related mRNAs in endometriosis
Authors: Ren Chengcheng , He Yanan , Wang Dejun , Li Jixin , Sun Liyuan , Zhang Guangmei 
Published: June 2023

AbstractBackground N6-methyladenosine(m6A) modification regulates the processes of RNA splicing, subcellular localization, translation and stability by changing the RNA structure and the interaction between RNA and RNA-binding proteins to ensure the timely and accurate expression of genes. In this study, we investigated m6A regulators and m6A-related genes and for the first time explored effective prevention and treatment targets in endometriosis (EM). Methods By incorporating the Gene Expression Omnibus (GEO) database, biological information analysis technologies, and validation of other databases, aberrant m6A-methylated genes and m6A-related genes were uncovered, as well as efficient therapeutic drugs. Results METTL3, RMB15B, FTO, YTHDF1, and YTHDF2 might be vital m6A regulators, and GGT5 and CAMK1D may be essential m6A-related genes of EM. A few crucial small-molecule agents supply new views for the treatment of EM. Conclusion These results demonstrated novel insights into m6A methylation of EM and revealed potential biomarkers and precision medicine strategies for EM.
Generation of multiple jet capillaries in advanced dielectric barrier discharge for large-scale plasma jets
Authors: Nguyen Duc Ba , Saud Shirjana , Trinh Quang Thang , An Hongjie , Nguyen Nam-Trung , Trinh Quang Hung , Do Hoang Tung , Mok Young Sun , Lee Won Gyu 
Published: June 2023

Abstract
Multiple Ar jet capillaries (4 jets) were successfully generated by an advanced dielectric barrier discharge reactor. The advanced reactor consisted of two ring-shaped electrodes (thickness of 0.5 mm) covering the 4-bore quartz tubing (bore diameters of 1 mm; outer diameter of 6 mm), and two electrodes had a gap of 6 mm and were isolated by immersing it to liquid dielectric to prevent arcing between two electrodes and high performance of plasma jet. The performance of multiple Ar jet capillaries by the advanced reactor demonstrated less consumption of Ar gas (1–3 L/min) for obtaining total π mm2 cross-section area of plasma jets conjugated with jet temperatures not over 40°C; the temperature is suitable for implementing plasma to bio-applications. Furthermore, the plasma jet spread when it interreacted with a surface (dielectric materials, skin); consequently, the surface-effected plasma jet up to an area square of 8 mm2. Analysis of optical emissions spectra of the multiple Ar jet capillaries indicated that the jet sources consist of reactivated species and proposed that the plasma device has potential for applications in bio-applications and materials treatments.
A Ranged-based Association Rule and GAN-based Hybrid Approach for Imbalanced Classification
Authors: Ahmed Zahid , Das Sufal 
Published: June 2023

Abstract
Machine learning has been extensively used in the field of automation systems, and in machine learning, imbalanced data is a prevalent word in fact it is a challenging element to deal with. How to deal with this imbalanced data is a major focus for the majority of studies. In terms of balancing the data, at the data level point under-sampling, over-sampling, and their variants are widely used. Since over-sampling creates precise replicas of examples from the minority class, it may increase the risk of over-fitting. Under-sampling wipes out a significant quantity of data, making it more difficult to determine where the decision boundary between minority and majority classes lies. In this work, a novel method has been proposed that combines both under-sampling and over-sampling strategies based on the Heuristic Range-Basd Association rule and a modified Tabular Generative Adversarial Network (TGAN) known as the Ranged-based Association rule and GAN-based Hybrid (RAMGANH) to avoid those kinds of problem scores and produce a well-balanced data set. The proposed approach has been tested by using existing standard classifiers with a few standard data sets, and the results demonstrate appreciable improvements in the classifier performance than the other state of-art-method.
Glucocorticoid receptor regulates the EMT process through GR/ZEB1/E-cad and is involved in breast cancer endocrine drug resistance
Authors: Tang Yuhan , Ma Jianli , Zhang Han , Ma Weiwei , Ma Wenjie , O'Keefe Thomas J. , Pratap Akshay , Yamada Akimitsu , Wang Lu , Gao Yuan , Zhang Qingyuan , Zhao Wenhui 
Published: June 2023

Abstract
Background
The glucocorticoid receptor (GR), estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR) belong to the steroid receptor family. Studies have shown that there is a cross-regulation between ER and GR that can affect the EMT process.
Methods
The present study verified the promoting effect of GR on breast cancer endocrine resistance. Survival and GR gene expression data was obtained from the METABRIC. GR gene expression profiling data were obtained from the GEO. Cytoscape was used to construct a PPI network and screen the key genes. Vimentin, E-cad, and Wnt/β-catenin gene expression data was obtained from TCGA. The co-expression method was employed to screen the key protein. The UALCAN and cBioPortal were used to verify the function of the key protein.
Results
In ER + breast cancer, GR and zinc finger E-box binding homeobox 1 (ZEB1) were lowly expressed and KEGG showed that down-regulated genes of GR differentially expressed genes were mainly enriched in cell adhesion molecules. We screened for the key protein ZEB1 and found that high levels of this protein in ER + breast cancer were positively associated with prolonged RFS in patients receiving endocrine therapy, while high levels of E-cad were negatively associated. GR expression was positively associated with ZEB1, negatively associated with E-cad, and negatively associated with the SET domain-containing 1B, histone lysine methyltransferase (SETD1B), a gene downstream of ZEB1. In contrast, ZEB1 expression was negatively correlated with E-cad and negatively correlated with SETD1B.
Conclusions
In ER + breast cancers, GR expression is suppressed, and the EMT process is inhibited by suppressing ZEB1 expression and thus promoting E-cad expression.