bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anomalous polarization enhancement in a van der Waals ferroelectric material under pressure
Authors: Yao Xiaodong , Bai Yinxin , Jin Cheng , Zhang Xinyu , Zheng Qunfei , Xu Zedong , Chen Lang , Wang Shanmin , Liu Ying , Wang Junling , Zhu Jinlong 
Published: July 2023

AbstractCuInP2S6 with robust room-temperature ferroelectricity has recently attracted much attention due to the spatial instability of its Cu cations and the van der Waals (vdW) layered structure. Herein, we report a significant enhancement of its remanent polarization by more than 50% from 4.06 to 6.36 µC cm−2 under a small pressure between 0.26 to 1.40 GPa. Comprehensive analysis suggests that even though the hydrostatic pressure suppresses the crystal distortion, it initially forces Cu cations to largely occupy the interlayer sites, causing the spontaneous polarization to increase. Under intermediate pressure, the condensation of Cu cations to the ground state and the polarization increase due cell volume reduction compensate each other, resulting in a constant polarization. Under high pressure, the migration of Cu cations to the center of the S octahedron dominates the polarization decrease. These findings improve our understanding of this fascinating vdW ferroelectric material, and suggest new ways to improve its properties.
The association between disability progression, relapses, and treatment in early relapse onset MS: an observational, multi-centre, longitudinal cohort study
Authors: Fuh-Ngwa Valery , Charlesworth Jac C. , Zhou Yuan , van der Mei Ingrid , Melton Phillip E. , Broadley Simon A. , Ponsonby Anne-Louise , Simpson-Yap Steve , Lechner-Scott Jeannette , Taylor Bruce V. 
Published: July 2023

AbstractThe indirect contribution of multiple sclerosis (MS) relapses to disability worsening outcomes, and vice-versa, remains unclear. Disease modifying therapies (DMTs) are potential modulators of this association. Understanding how these endo-phenotypes interact may provide insights into disease pathogenesis and treatment practice in relapse-onset MS (ROMS). Utilising a unique, prospectively collected clinical data from a longitudinal cohort of 279 first demyelinating event cases followed for up to 15 years post-onset, we examined indirect associations between relapses and treatment and the risk of disability worsening, and vice-versa. Indirect association parameters were estimated using joint models for longitudinal and survival data. Early relapses within 2.5 years of MS onset predicted early disability worsening outcomes (HR = 3.45, C.I 2.29–3.61) per relapse, but did not contribute to long-term disability worsening thereinafter (HR = 0.21, C.I 0.15–0.28). Conversely, disability worsening outcomes significantly contributed to relapse risk each year (HR = 2.96, C.I 2.91–3.02), and persisted over time (HR = 3.34, C.I 2.90–3.86), regardless of DMT treatments. The duration of DMTs significantly reduced the hazards of relapses (1st-line DMTs: HR = 0.68, C.I 0.58–0.79; 3rd-line DMTs: HR = 0.37, C.I 0.32–0.44) and disability worsening events (1st-line DMTs: HR = 0.74, C.I 0.69–0.79; 3rd-line DMTs: HR = 0.90, C.I 0.85–0.95), respectively. Results from time-dynamic survival probabilities further revealed individuals having higher risk of future relapses and disability worsening outcomes, respectively. The study provided evidence that in ROMS, relapses accrued within 2.5 years of MS onset are strong indicators of disability worsening outcomes, but late relapses accrued 2.5 years post onset are not overt risk factors for further disability worsening. In contrast, disability worsening outcomes are strong positive predictors of current and subsequent relapse risk. Long-term DMT use and older age strongly influence the individual outcomes and their associations.
Chemical bonding in americium oxides probed by X-ray spectroscopy
Authors: Butorin Sergei M. , Shuh David K. 
Published: July 2023

AbstractThe electronic structure and the chemical state in Am binary oxides and Am-doped UO$$_2$$

2

were studied by means of X-ray absorption spectroscopy at shallow Am core (4d and 5d) edges. In particular, the Am 5f states were probed and the nature of their bonding to the oxygen states was analyzed. The interpretation of the experimental data was supported by the Anderson impurity model (AIM) calculations which took into account the full multiplet structure due to the interaction between 5f electrons as well as the interaction with the core hole. The sensitivity of the branching ratio of the Am $$4d_{3/2}$$

4

d

3
/
2

and $$4d_{5/2}$$

4

d

5
/
2

X-ray absorption lines to the chemical state of Am was shown using Am binary oxides as reference systems. The observed ratio for Am-doped UO$$_2$$

2

suggests that at least at low Am concentrations, americium is in the Am(III) state in the UO$$_2$$

2

lattice. To confirm the validity of the applied AIM approach, the analysis of the Am 4f X-ray photoelectron spectra of AmO$$_2$$

2

and Am$$_2$$

2

O$$_3$$

3

was also performed which revealed a good agreement between experiment and calculations. As a whole, AmO$$_2$$

2

can be classified as the charge-transfer compound with the 5f occupancy ($$n_f$$

n
f

) equal to 5.73 electrons, while Am$$_2$$

2

O$$_3$$

3

is rather a Mott–Hubbard system with $$n_f$$

n
f

= 6.05.
Non-volatile reconfigurable spin logic functions in a two-channel Hall bar by spin–orbit torque-based magnetic domains and directional read current
Authors: Shin JeongHun , Seo Jeongwoo , Song Saegyoung , Kim WooJong , Hyeon Da Seul , Hong JinPyo 
Published: July 2023

AbstractA long-standing goal of CMOS-based logic devices is to meet the needs of key markets, including ultralow-power operation and high operation speed, along with the continuing miniaturization of the architecture. However, despite significant progress in their development, conventional CMOS-based devices still suffer from drawbacks such as introducing large unintended leakage currents and volatile behavior. Thus, reconfigurable logic gates based on magnetic domain (MD) have emerged as a highly promising option because they offer fast operation speeds, nonvolatility, and diverse logic functions in a single-device configuration. Here, we address multiple reconfigurable MD logic gates in a single two-channel Hall bar device by varying the voltage-driven read-current directions and selecting a non-inverting or inverting comparator in W/CoFeB/MgO/Ta stacks. The non-volatile MD switching behavior induced by spin–orbit torque significantly affects our logic gate functions, which are not necessarily synchronized to a single clock. By adapting MD switching by spin-orbit torque and anomalous Hall effect voltage outputs, we identified eight reconfigurable logic gates, including AND, NAND, NOR, OR, INH, Converse INH, Converse IMP, and IMP, in a single device. These experimental findings represent a significant step forward in a wide range of MD-based logic applications in the near future.
Retinol intake is associated with the risk of chronic kidney disease in individuals with type 2 diabetes mellitus: results from NHANES
Authors: Ma Rong , Xie Chunpeng , Wang Shaoqing , Xiao Xiang 
Published: July 2023

AbstractThe aim of this study was to investigate the potential association between retinol intake and the risk of chronic kidney disease (CKD) in individuals with type 2 diabetes mellitus (T2DM). The study included individuals diagnosed with T2DM between 2009 and 2018 from the NHANES database. Demographic and laboratory test data were collected for these individuals, as well as information on CKD diagnosis. Logistic regression models were utilized to estimate the relationship between different retinol intakes and the risk of CKD in patients with T2DM. A total of 3988 patients were included in the study. The mean prevalence of CKD in the T2DM population in the United States from 2009 to 2018 was 36.98 (0.02)%. Multivariate logistic regression analysis revealed a 26% decrease in the incidence of CKD in individuals with higher retinol intake compared to those with lower retinol intake in T2DM (OR = 0.74; 95% CI 0.56–0.98). Furthermore, an increase in retinol intake per 1-standard deviation (SD) was associated with a 16% decreased risk of the incidence of CKD (OR = 0.84; 95% CI 0.72–0.97). Lower retinol intake is an independent risk factor for the onset of CKD in patients with T2DM, and augmenting moderate quantities of retinol confers potential nephroprotective advantages.
Insights into peculiar fungal LPMO family members holding a short C-terminal sequence reminiscent of phosphate binding motifs
Authors: Reyre Jean-Lou , Grisel Sacha , Haon Mireille , Xiang Ruite , Gaillard Jean-Charles , Armengaud Jean , Guallar Victor , Margeot Antoine , Arragain Simon , Berrin Jean-Guy , Bissaro Bastien 
Published: July 2023

AbstractLytic polysaccharide monooxygenases (LPMOs) are taxonomically widespread copper-enzymes boosting biopolymers conversion (e.g. cellulose, chitin) in Nature. White-rot Polyporales, which are major fungal wood decayers, may possess up to 60 LPMO-encoding genes belonging to the auxiliary activities family 9 (AA9). Yet, the functional relevance of such multiplicity remains to be uncovered. Previous comparative transcriptomic studies of six Polyporales fungi grown on cellulosic substrates had shown the overexpression of numerous AA9-encoding genes, including some holding a C-terminal domain of unknown function (“X282”). Here, after carrying out structural predictions and phylogenetic analyses, we selected and characterized six AA9-X282s with different C-term modularities and atypical features hitherto unreported. Unexpectedly, after screening a large array of conditions, these AA9-X282s showed only weak binding properties to cellulose, and low to no cellulolytic oxidative activity. Strikingly, proteomic analysis revealed the presence of multiple phosphorylated residues at the surface of these AA9-X282s, including a conserved residue next to the copper site. Further analyses focusing on a 9 residues glycine-rich C-term extension suggested that it could hold phosphate-binding properties. Our results question the involvement of these AA9 proteins in the degradation of plant cell wall and open new avenues as to the divergence of function of some AA9 members.
Immunogenicity and safety of inactivated SARS-CoV-2 vaccine in haemodialysis patients: a prospective cohort study
Authors: Puspitasari Metalia , Sattwika Prenali D. , Rahari Dzerlina S. , Wijaya Wynne , Hidayat Auliana R. P. , Kertia Nyoman , Purwanto Bambang , Thobari Jarir At 
Published: July 2023

AbstractEnd-stage renal disease patients on haemodialysis (HD) have been largely excluded from SARS-CoV-2 vaccine trials due to safety reasons and shown to mount lower responses to vaccination. This study aims to evaluate the immunogenicity and safety of inactivated COVID-19 vaccine among HD patients compared to healthy controls. All subjects who received the primary inactivated COVID-19 vaccination had their blood samples tested 21 days after the second dose. We report the immunogenicity based on anti-RBD IgG titre (IU/mL), the inhibition rate of neutralizing antibodies (NAbs) (%) to RBD, and seroconversion rates. Adverse events were assessed within 30 min and on the 7th day after each dose. Among 75 HD patients and 71 healthy controls, we observed no significant difference in all immunogenicity measures: anti-RBD IgG GMT (277.91 ± 7.13 IU/mL vs. 315.50 ± 3.50 IU/mL, p = 0.645), NAbs inhibition rate (82% [53–96] vs. 84% [39–98], p = 0.654), and seroconversion rates (anti-RBD IgG: 86.7% vs. 85.9%, p = 0.895; NAbs: 45.3% vs. 60.6%, p = 0.065). The number of adverse events is not significantly different between the two groups. The primary inactivated SARS-CoV-2 vaccination elicits an adequate antibody response and can be safely administered in haemodialysis patients.
Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer
Authors: Ota Hayato , Sato Hirokazu , Mizumoto Shuji , Wakai Ken , Yoneda Kei , Yamamoto Kazuo , Nakanishi Hayao , Ikeda Jun-Ichiro , Sakamoto Shinichi , Ichikawa Tomohiko , Yamada Shuhei , Takahashi Satoru , Ikehara Yuzuru , Nishihara Shoko 
Published: July 2023

AbstractAndrogen deprivation therapy is given to suppress prostate cancer growth; however, some cells continue to grow hormone-independently as castration-resistant prostate cancer (CRPC). Sulfated glycosaminoglycans promote ligand binding to receptors as co-receptors, but their role in CRPC remains unknown. Using the human prostate cancer cell line C4-2, which can proliferate in hormone-dependent and hormone-independent conditions, we found that epidermal growth factor (EGF)-activated EGFR–ERK1/2 signaling via 3-O-sulfated heparan sulfate (HS) produced by HS 3-O-sulfotransferase 1 (HS3ST1) is activated in C4-2 cells under hormone depletion. Knockdown of HS3ST1 in C4-2 cells suppressed hormone-independent growth, and inhibited both EGF binding to the cell surface and activation of EGFR–ERK1/2 signaling. Gefitinib, an EGFR inhibitor, significantly suppressed C4-2 cell proliferation and growth of a xenografted C4-2 tumor in castrated mouse. Collectively, our study has revealed a mechanism by which cancer cells switch to hormone-independent growth and identified the key regulator as 3-O-sulfated HS.
Amphioxus adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U and A-to-I deamination of DNA
Authors: Gao Zhan , Jiang Wanyue , Zhang Yu , Zhang Liping , Yi Mengmeng , Wang Haitao , Ma Zengyu , Qu Baozhen , Ji Xiaohan , Long Hongan , Zhang Shicui 
Published: July 2023

AbstractAdenosine-to-inosine tRNA-editing enzyme has been identified for more than two decades, but the study on its DNA editing activity is rather scarce. We show that amphioxus (Branchiostoma japonicum) ADAT2 (BjADAT2) contains the active site ‘HxE-PCxxC’ and the key residues for target-base-binding, and amphioxus ADAT3 (BjADAT3) harbors both the N-terminal positively charged region and the C-terminal pseudo-catalytic domain important for recognition of substrates. The sequencing of BjADAT2-transformed Escherichia coli genome suggests that BjADAT2 has the potential to target E. coli DNA and can deaminate at TCG and GAA sites in the E. coli genome. Biochemical analyses further demonstrate that BjADAT2, in complex with BjADAT3, can perform A-to-I editing of tRNA and convert C-to-U and A-to-I deamination of DNA. We also show that BjADAT2 preferentially deaminates adenosines and cytidines in the loop of DNA hairpin structures of substrates, and BjADAT3 also affects the type of DNA substrate targeted by BjADAT2. Finally, we find that C89, N113, C148 and Y156 play critical roles in the DNA editing activity of BjADAT2. Collectively, our study indicates that BjADAT2/3 is the sole naturally occurring deaminase with both tRNA and DNA editing capacity identified so far in Metazoa.
Room temperature electron–hole liquid phase in monolayer MoSi2Z4 (Z = pinctogen)
Authors: Yadav Pushpendra , Adarsh K V , Agarwal Amit 
Published: July 2023

Abstract
Photo-excited electrons and holes in insulators, above a critical density and below a critical temperature, can condense to form an electron–hole liquid (EHL) phase. However, observing the EHL phase at room temperature is extremely challenging. Here, we introduce the monolayer

M
o
S
i

2

Z

4

(Z = N, As, P) series of compounds as a promising platform for observing the EHL phase at room temperature. The higher impact of the Coulomb interactions in two dimensions helps these monolayers support the EHL phase with an increased EHL binding energy and transition temperature, along with strongly bound excitons. Our findings motivate further exploration of the

M
o
S
i

2

Z

4

monolayers for realizing the EHL phase at high temperatures to harness collective phenomena for optoelectronic applications.
Tree canopy density thresholds for improved forests cover estimation in protected areas of Madagascar
Authors: Rafanoharana Serge Claudio , Andrianambinina Fatany Ollier Duranton , Rasamuel Henintsoa Andry , Waeber Patrick Olivier , Ganzhorn Joerg Ulrich , Wilmé Lucienne 
Published: July 2023

Abstract
The rich endemic biodiversity of Madagascar is concentrated in different types of natural forests primarily conserved within the network of protected areas (PAs). Since 1990, remote sensing has been utilized to monitor forest cover. The latest forest cover map generated using these techniques provides accurate estimates of natural forest cover within the PAs network. However, the standardized application of Tree Canopy Density (TCD), as used in global assessments of forest cover, yields erroneous estimates for different forest types in Madagascar because the standard TCD cannot be globally applied to all types of forests. Our study aims to utilize global remote sensing data at the scale of PAs to identify specific TCD thresholds for individual PAs. Starting from the year 2000 data, the application of these thresholds will allow us to estimate deforestation in subsequent years at reduced costs. We used the official PA boundaries, a reliable forest cover map at the national scale, and the TCDs published at a global scale to infer the values of TCD to be applied in each PA. The standard TCD threshold above 30% overestimates humid and dry forests and underestimates dry spiny forests in Madagascar. Our specific TCD thresholds inferred for each PA accurately estimate the forest cover in the vast majority of PAs. Using these specific TCD thresholds will allow for improved monitoring of forest cover within the network of PAs. The methodology detailed here can also be applied in other geographic regions, and future improvements in data on forest cover—both remotely sensed and field-collected—will enhance our ability to estimate forest cover and its changes over time.
Principles of White Analytical Chemistry and Design of Experiments to Development of Stability-Indicating Chromatographic Method for the Simultaneous Estimation of Thiocolchicoside and Lornoxicam
Authors: Prajapati Pintu , Pulusu Veera Shakar , Shah Shailesh 
Published: July 2023

Abstract

Background
A variety of chromatographic methods have been published for the stability evaluation of thiocolchicoside (THC) and lornoxicam (LNX). Nevertheless, the development of chromatographic methods requires the use of neurotoxic and teratogenic organic solvents that are detrimental to the environment and harmful to human life.

Objectives
Using the principles of design of experiments (DoE), a novel white analytical chemistry-driven stability-indicating high-performance thin-layer chromatographic (SI-HPTLC) method has been developed for the concurrent stability study of THC and LNX. To protect the environment and human life, the stability-indicating HPTLC method was developed using safe organic solvents.

Method
Potential analytical method risk parameters (AMRPs) and analytical method performance attributes (AMPAs) were screened using the fractional factorial design. The response surface analysis and optimization of critical AMRPs and AMPAs was carried out using full factorial design. Navigation of the method operable design region (MODR) was used to develop the SI-HPTLC technique. The developed method was validated in accordance with the International Council for Harmonization (ICH) Q2 (R1) guideline.

Results
The developed method’s greenness was evaluated using the AGREE (Analytical Procedure Greenness) tool and ESA (Eco-Scale Assessment). The Blue (B) model was used to assess the proposed method’s cost and time efficiency and user-friendliness. For the stability studies of THC and LNX, the 12 principles of WAC (white analytical chemistry) were used to evaluate the published and proposed chromatographic techniques.

Conclusions
Compared to previously published chromatographic techniques for studying the stability of THC and LNX, the suggested approach was found to be more affordable, environmentally friendly, and user-friendly.

Highlights
The development of a stability-indicating HPTLC method using a novel white analytical chemistry approach and organic solvents with low toxicity potential. Application of the developed method for analysis of the forced degraded sample and fixed-dose combinations of THC and LNX.
Telemedicine support aids lower limb reconstruction after combat injury in Ukraine
Authors: Khomenko Igor P , Lurin Igor A , Gumeniuk Konstiantyn V , McKnight Gerard , Makarov Vitaliy V , Nehoduyko Volodymyr V , Khoroshun Eduard , Tertyshnyi Serhii V 
Published: July 2023

Abstract
Since the destructive and illegal full-scale invasion of Ukraine in February 2022, caring for the victims of war trauma has been an essential function of Ukrainian clinicians [ 1, 2]. The authors present a case where using novel dynamic digital thermography (DDT), combined with international telemedicine support, contributed to saving the lower limb of an injured Ukrainian soldier. A male soldier in his 30s presented with a ‘through and through’ fragmentation wound to the right thigh from an artillery shell exploding nearby. After initial haemorrhage control and resuscitation, the patient was transferred to a tertiary hospital. Using telemedicine support, reconstructive surgery was planned and performed successfully using a perforating flap technique. DDT was used pre-operatively to identify a perforating vessel and post-operatively to ensure perfusion of the flap. The patient made a good recovery and was discharged 14 d post-operatively.
The Haunted Cane Fields of Queer Indo-Caribbean Poetry and Qoolie Poetics
Authors: Mohabir Rajiv 
Published: July 2023

Abstract
This chapter looks at four Indo-Caribbean poets who identify as queer to show the potential of Ryan Persadie’s notion of the Qoolie. The chapter also expands this term’s usage to include queer discursive possibilities for the poetics of the descendants of the Indian labor diaspora. The specific focus in this chapter is on descendants living in the Caribbean as well as those who have migrated to North America. The chapter begins by discussing the history of framing the Indo-Caribbean diaspora and its relationship with India. Then, the chapter posits how form, history, and language usage constellate a Qoolie poetics in the written poetry of Shivanee Ramlochan, Andre Bagoo, Faizal Deen, and Shani Mootoo, through the constitutive tropes of hauntings, reclamations, and fragmentations.
Consumer food waste decisions in British and Thai consumers: A vignette approach
Authors: Walter Ponjan , Asioli Daniele , Balcombe Kelvin 
Published: July 2023

AbstractThis study uses an experimental vignette methodology to investigate and compare, for the first time, consumer food waste (FW) decisions in the UK and Thailand. Specifically, we examine consumers’ decisions to discard leftovers during meal scenarios affected by varying economic and contextual factors. Different consumer segments are identified and characterised, and our results suggest that consumers in the UK and Thailand are more likely to save leftovers when dining at home, when meals are expensive, and when a whole meal is left over. We discuss these findings and provide recommendations for practitioners and policymakers aiming to reduce FW.