bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual and reproductive health rights and service use among undocumented migrants in the EU: a systematic literature review
Authors: Mandroiu Alexandra , Pavlova Milena , Groot Wim 
Published: March 2023

Abstract

Background
Most EU member states fail to provide comprehensive access to essential sexual reproductive health services to undocumented migrants. This population group is, therefore, specifically vulnerable to experiencing worse health outcomes related to sexual and reproductive health. The aim of this study is to systematically review the academic literature on the access to and use of sexual reproductive health services as well as related health outcomes for undocumented migrants in the EU.
Methods
We systematically searched PubMed, Embase, and Cinahl/Ebsco to identify quantitative, qualitative, and mixed methods studies published between 2017 and 2022 (last 5 years).
Results
A total of 996 records were retrieved. The deduplication left 814 studies. After screening titles, abstracts, and full texts according to pre-defined inclusion and exclusion criteria, 37 articles were included in the review. Overall findings indicated a variety of access barriers such as refusal of care, lack of knowledge and information on national healthcare provision schemes, bureaucratic and administrative hurdles, as well as affordability difficulties. Even when sexual reproductive health services were available and accessible, the studies reported a variety of factors affecting the use of such services by undocumented migrant populations, e.g., stigma, fear of deportation, socio-economic precarity, or abuse. All this translates into generally reported worse reproductive health outcomes for this population group.
Conclusion
Although it is hard to generalize the present findings to the EU region, this review furthers the evidence that undocumented migrants in Europe face worse reproductive health outcomes related to barriers to access and utilization of reproductive health services.
Functional state and rehabilitation of patients after primary brain tumor surgery for malignant and non-malignant tumors: a prospective observational study
Authors: Krajewski Stanisław , Furtak Jacek , Zawadka-Kunikowska Monika , Kachelski Michał , Soboń Jakub , Harat Marek 
Published: March 2023

Abstract
Background: There have been several attempts to develop rehabilitation programs for brain tumor patients with poor quality of life, but these studies usually failed to take tumor malignancy into account. Determining the functional status throughout postoperative recovery would help us to understand the dynamics and effectiveness of rehabilitation, and taking tumor type into account may help to preselect patients for rehabilitation services or prioritize needs. The aim of this study was to compare the pre- and post-operative function of patients qualifying for initial resection of malignant and non-malignant primary brain tumors to determine the relationship between tumor type, function, and the course of rehabilitation after surgery.
Methods: This was a single-center, prospective, observational study (two intervention groups) conducted in a tertiary neurosurgical inpatient unit. Ninety-two patients required prolonged postoperative rehabilitation during their inpatient stay and were divided into a non-malignant tumor group (n=66) and a malignant tumor group (n=26). The Karnofsky performance status, Barthel index, and the modified Rankin scale were used to assess functional status, while the gait index was used to assess gait efficiency. Motor skills, postoperative complications, and length of hospital stay (LoS) were recorded and compared between groups.
Results: The frequency and severity of postoperative complications, the time needed to attain individual motor skills, and the proportion of patients who lost independent gait (~30%) were similar between non-malignant and malignant groups. However, paralysis and paresis were more frequent in the malignant tumor group before surgery (p<0.001). While non-malignant tumor patients deteriorated more according to all scales after surgery, patients with malignant tumors were still characterized by worse ADL, independence, and performance at discharge. Worse functional outcomes in the malignant tumor group did not affect LoS or rehabilitation.
Conclusions: Patients with malignant and non-malignant tumors have similar rehabilitation needs, and patient expectation – especially those with non-malignant tumors - should be appropriately managed. Counterintuitively, patients with non-malignant tumors might require more rather than less counselling and support given their greater deterioration after surgery.
A Study of Knowledge on Alzheimer's Disease and Attitudes of Chinese Social Residents towards Alzheimer’s disease: a cross-sectional survey in China
Authors: Rui Lu , Ning Qiao , Jin Song , Ziqiong Wang , Jiarui Zhao , Ruxia Yu , Qiucheng Wang , Jing Jiang 
Published: March 2023

Abstractobjective:Social residents become increasingly concerned about Alzheimer's dementia (AD) as a global public health crisis. China's AD population is the largest and growing fastest. However, no study has examined Chinese social residents' knowledge and attitudes concerning Alzheimer's illness. This study examined Chinese social residents' AD knowledge and attitudes using the ADKS and DAS.Study design:Cross-sectional survey. 338 social residents over 18 from various Chinese regions were recruited using convenient sampling.Method:The Alzheimer's Disease Knowledge Scale (Chinese) and the Dementia Attitude Scale (Chinese) were used to assess their knowledge and attitude regarding AD.Results:A total of 328 respondents (97.04%) completed the survey. ADKS = 19.44±3.33; DAS = 86.98±12.7. Age and education level can have a substantial impact on ADKS scores, and education level can have a substantial impact on DAS scores.Conclusion:Low levels of awareness and acceptance of AD exist among Chinese residents. The results indicate that China must immediately implement comprehensive AD education for its social residents.
Long-term reliable neural decoding based on flexible implantable microelectronics and machine learning for seizure prediction application
Authors: He Zicong , Zheng Jiajun , Duan Junwei , Jin Zhe , Huang Zixuan , Wu Shuaishuai , He Qian , So Kwok-Fai , Zhang Shuixing , Xiong Zhiyuan 
Published: March 2023

Abstract
Neural decoding is useful for understanding brain functions and developing neural interface applications. However, neural interfaces based on rigid electronics often suffer from recording instability due to the foreign body responses caused by their mechanical mismatch with soft tissues, limiting the longitudinal accuracy of neural decoding methods. Herein, it is reported that flexible electronics can be integrated with machine learning algorithms to achieve long-term reliable neural decoding. Wet-spun conductive polymer microfibers showed mechanical robustness and flexibility, low impedance, and chronic biocompatibility, enabling intracerebral neural recordings in epileptic mice at a high signal-to-noise ratio eight weeks after implantation. When the signals recorded by the flexible electrodes were used in machine learning analyses with diverse complex algorithms, they consistently showed higher prediction accuracy for epileptic seizures than stiff metal electrode signals, particularly in the case of using long-term recordings for testing or small-sample datasets for training. A real-time warning system based on the flexible neural electrodes was built that predicted seizures eight minutes in advance with a low false alarm rate. Our work bridges flexible electronics and artificial intelligence for neural decoding applications such as long-term treatment of chronic neurological disorders.
Cross-modal Retrieval based on Shared Proxies
Authors: Wei Yuxin , Zheng Ligang , Qiu Guoping , Cai Guocan 
Published: March 2023

Abstract
Inconsistency of distribution and representation across different data modalities makes measuring cross-modal similarities a very difficult problem. Learning a common space that is semantically discriminative and modality invariant is the main challenge in cross-modal retrieval. Existing solutions usually employ pairwise or triplet data relationships to learn the common space, which can only capture the data similarity locally but would be unable to effectively characterize the global geometry of the common embedding space, and thus would limit the performance of cross-modal retrieval. In this paper, we introduce a shared proxy solution to cross-modal retrieval. We propose to incorporate the principles of shared proxy with neighbourhood component analysis to learn a common space for different modalities in which the distance between a sample’s representation and its corresponding proxy is minimized while the distances between a sample’s representation and the proxies not belonging to the sample are maximized. We propose the Cross-mOdal proXy learnIng (COXI) framework which integrates a cross-modal shared proxy loss, a discriminative loss and a modality invariant loss for supervised cross-modal retrieval. Extensive experiments on benchmark datasets clearly shows that COXI outperforms state of the art cross-modal retrieval techniques. Code is available on https://github.com/LigangZheng/COXI.
How Innovativeness Influence on Women Business Performance
Authors: Sugiyanto Eviatiwi Kusumaningtyas , Wijayanti Ratna 
Published: March 2023

The problem in this study is that there are still various controversies in the results of research regarding the relationship and influence between innovations on performance. In addition, there is also a gap, namely the increasing number of women’s businesses on the one hand and on the other hand, the success of women’s businesses tends to be lower than that of men’s businesses. So this study aims to close the research gap, namely the influence of Innovativeness on business performance by mediating competitive advantage. The sample is 62 women entrepreneurs. Methods of data collection using a questionnaire via google form. The data analysis method uses SEM with the WrapPLS 7.0 program. The results show that Innovation has a significant positive effect on Competitive Advantage, but has no effect on Business Performance. Meanwhile, Competitive Advantage has a significant positive effect on Business Performance and has succeeded in becoming a mediator (full mediation) for Innovation and Business Performance.
The Effect of Owner’s Characteristics through Innovation on the MSMEs Performance
Authors: Wulandari Ririn , Koe Wei-Loon 
Published: March 2023

This study aims to analyze the influence of the characteristics of MSME owners on their performance through innovation in Indonesia and Malaysia. Structural Equation Modeling (SEM) was used to analyze the data, with the Smart-PLS program. The population in this study was Micro, Small, and Medium Enterprises from various types of businesses. The number of respondents was 225 from Indonesia and Malaysia. The sampling technique used was stratified judgment sampling. Questionnaire in the form of Google Forms and distributed via WhatsApp, Facebook, and Instagram. The study results show that innovation affects the performance of MSMEs in Indonesia and Malaysia. In Indonesia, owner characteristics influence innovation but do not affect performance. With the characteristics they have, MSME owners can improve their performance through the creation of innovations. However, this is not the case in Malaysia.
Mechanism of oxidative damage in Escherichia coli caused by epigallocatechin gallate (EGCG) in the presence of calcium ions
Authors: Feng Cuimin , Luo Jia-cheng , Liu Xuan-qi , Huang Lu-meng , Yu Hong-ying , Wang Chang-zheng , Zhang Jin-shuang 
Published: March 2023

Abstract
Tea polyphenols can be developed into new types of disinfectants for drinking water. The antibacterial effect of epigallocatechin gallate (EGCG) on Escherichia coli (E. coli) in the presence of Ca2+ is affected by the Ca2+ concentration. The oxidative damage mechanism and oxidative damage process of EGCG in E. coli under the presence of Ca2+ were deeply analyzed under three aspects: reactive oxygen species (ROS), antioxidant system, and oxidative stress response in E. coli to provide a theoretical basis for the use of EGCG as a disinfectant in drinking water disinfection. EGCG leads to excessive production of superoxide anion in E. coli and the presence of Ca2+ promotes further imbalance of superoxide anion in E. coli; Ca2+ has little effect on EGCG hindering the scavenging of hydroxyl radicals in bacteria; EGCG can hinder the effect of antioxidant enzymes in E. coli, and Ca2+ has a particular regulatory effect on antioxidant enzymes, thus hindering the oxidative damage of EGCG to E. coli; Ca2+ can cause the expression of the oxyR and DPS genes, protect bacterial DNA, and prevent EGCG from damaging bacterial DNA. In the presence of a high concentration of Ca2+, it may activate the cell efflux pump through the soxS gene, resulting in E. coli resistance to EGCG.
Using a blue landscape to mitigate heat stress during a heatwave event: a simulation study in a hot-humid urban environment
Authors: Zeeshan Muhammad , Ali Zaib 
Published: March 2023

AbstractThe urban heat island (UHI) phenomenon and climate change have become the major concerns for city sustainability in the wake of global warming and rapid growth in urbanization. This has resulted in increased intensity of heat stress and worsened outdoor thermal environmental conditions in urban microclimates. Water bodies are among the most effective means to alleviate the UHI and improve the thermal environment of urban microclimates. The thermal comfort conditions are observed at the pedestrian's level in a horizontal direction and at different vertical levels by assessing the reduction in three variables: ambient air temperature, surface temperatures, and alteration of flow velocity. The water body model used in this simulation is first validated using the sub-configuration method by replicating a previous experimental study. Two different scenarios (one with a realistic setting and the other with a representative water body) were studied and the results show that, for isolated streets, the water bodies can effectively improve thermal comfort conditions by reducing ambient air temperature (i.e. a reduction of 0.9 °C) and surface temperature by 3.5 °C, thereby reducing energy consumption. Moreover, a significant increase in wind velocity was also observed reaching its maximum value at peak times of thermal stress.
Bioremoval efficiency and metabolomic profiles of cellular responses of Chlorella pyrenoidosa to phenol and 4-fluorophenol
Authors: Li Min , Ma Lu , An Yajing , Wei Dongbin , Ma Haijun , Zhu Juanjuan , Wang Cuiping 
Published: March 2023

Abstract
We examined the growth tolerance, bioremoval efficacy, and metabolomic profiles of the cellular responses of Chlorella pyrenoidosa to phenol and 4-fluorophenol. We found that C. pyrenoidosa can tolerate exposure to 100 mg/L of phenol and 4-fluorophenol, and the growth of algal cells had a significant hormesis of inhibition first and then promotion. Up to 70% bioremoval of phenol and 4-fluorophenol may occur after 240 h of treatment. Superoxide dismutase (SOD) and CAT activities, malondialdehyde (MDA) content, and reactive oxygen species (ROS) in algal cells in the phenol- and 4-fluorophenol-treated groups were similar or lower than in the control group. Furthermore, photosynthetic pigment and glycerophospholipid contents were significantly upregulated in both phenol- and 4-fluorophenol-treated groups, as indicated by the metabolomic analysis of C. pyrenoidosa, resulting in the vigorous growth of algal cells compared to the control group. Therefore, C. pyrenoidosa can be an excellent biosorbent for phenol and 4-fluorophenol.
Anti-colorectal Cancer Activity of Quinazoline Derivatives: A Comprehensive
Review
Authors: Singh Madan , Chandraker Vivek , Karthikeyan Chandrabose , Moorthy Narayana Subbiah Hari Narayana 
Published: March 2023

Introduction and Objective:
The identification of a bioactive template (or lead) is one of the
important features of modern drug discovery. Natural products, synthetic and biotechnological sources,
serve as important templates for the development of novel bioactive molecules. Quinazoline is one of the
heterocyclic templates present in many natural and synthetic drugs and exhibits various biological activities,
including anticancer, by blocking the pharmacological pathway of different targets.

Methodology:
In this study, the data was collected from the literature and patents to examine the anticolorectal
cancer efficacy of quinazoline compounds and their mechanism of actions. According to the
published literature and patents, the benzene and/or pyrimidine rings of the quinazoline have been substituted
with amino groups or substituted amino groups to develop novel analogues endowed with anticancer
properties. The anti-colorectal cancer activity of quinazolines was due to the flexible chain containing
terminal phenyl and/or heterocyclic rings (thiazole, pyrazole, piperidine, piperazine, etc.).

Results:
These quinazoline derivatives were found to inhibit the growth of colorectal cancer cells by
modulating the expression of specific genes and proteins involved in cancer progression, such as receptor
tyrosine kinases, epidermal growth factor receptors, dihydrofolate reductase, topoisomerases, histone
deacetylase, and apoptotic proteins.

Conclusion:
These findings suggest that the quinazoline nucleus may be exploited to identify new anticolorectal
cancer agents with suitable pharmacokinetic profiles.
Insulin Glargine in Type 1 Diabetes Mellitus: A Review of Clinical Trials
and Real-world Evidence Across Two Decades
Authors: Saboo Banshi , Chandalia Hemraj , Ghosh Sujoy , Kesavadev Jothydev , Kochar IPS , Prasannakumar KM , Sarda Archana , Bantwal Ganapathi , Mehrotra RN , Rai Madhukar 
Published: March 2023

Background:
Over the past two decades, insulin glargine 100 U/mL (Gla-100) has
emerged as the “standard of care” basal insulin for the management of type 1 diabetes mellitus
(T1DM). Both formulations, insulin glargine 100 U/mL (Gla-100) and glargine 300 U/mL (Gla-
300) have been extensively studied against various comparator basal insulins across various clinical
and real-world studies. In this comprehensive article, we reviewed the evidence on both insulin
glargine formulations in T1DM across clinical trials and real-world studies.

Methods:
Evidence in T1DM for Gla-100 and Gla-300 since their approvals in 2000 and 2015, respectively,
were reviewed.

Results:
Gla-100 when compared to the second-generation basal insulins, Gla-300 and IDeg-100,
demonstrated a comparable risk of overall hypoglycemia, but the risk of nocturnal hypoglycemia
was higher with Gla-100. Additional benefits of Gla-300 over Gla-100 include a prolonged (>24-
hours) duration of action, a more stable glucose-lowering profile, improved treatment satisfaction,
and greater flexibility in the dose administration timing.

Conclusion:
Both glargine formulations are largely comparable to other basal insulins in terms of
glucose-lowering properties in T1DM. Further, risk of hypoglycemia is lower with Gla-100 than
Neutral Protamine Hagedorn but comparable to insulin detemir.
The Effectiveness of Smartphone App–Based Interventions for Assisting Smoking Cessation: Systematic Review and Meta-analysis
Authors: Guo Yi-Qiang , Chen Yuling , Dabbs Annette DeVito , Wu Ying 
Published: March 2023

Background
Smoking is a leading cause of premature death globally. Quitting smoking reduces the risk of all-cause mortality by 11%-34%. Smartphone app–based smoking cessation (SASC) interventions have been developed and are widely used. However, the evidence for the effectiveness of smartphone-based interventions for smoking cessation is currently equivocal.

Objective
The purpose of this study was to synthesize the evidence for the effectiveness of smartphone app–based interventions for smoking cessation.

Methods
We conducted a systematic review and meta-analysis of the effectiveness of smartphone interventions for smoking cessation based on the Cochrane methodology. An electronic literature search was performed using the Cochrane Library, Web of Science, PubMed, Embase, PsycINFO, China National Knowledge Infrastructure, and Wanfang databases to identify published papers in English or Chinese (there was no time limit regarding the publication date). The outcome was the smoking abstinence rate, which was either a 7-day point prevalence abstinence rate or a continuous abstinence rate.

Results
A total of 9 randomized controlled trials involving 12,967 adults were selected for the final analysis. The selected studies from 6 countries (the United States, Spain, France, Switzerland, Canada, and Japan) were included in the meta-analysis between 2018 and 2022. Pooled effect sizes (across all follow-up time points) revealed no difference between the smartphone app group and the comparators (standard care, SMS text messaging intervention, web-based intervention, smoking cessation counseling, or apps as placebos without real function; odds ratio [OR] 1.25, 95% CI 0.99-1.56, P=.06, I2=73.6%). Based on the subanalyses, 6 trials comparing smartphone app interventions to comparator interventions reported no significant differences in effectiveness (OR 1.03, 95% CI 0.85-1.26, P=.74, I2=57.1%). However, the 3 trials that evaluated the combination of smartphone interventions combined with pharmacotherapy compared to pharmacotherapy alone found higher smoking abstinence rates in the combined intervention (OR 1.79, 95% CI 1.38-2.33, P=.74, I2=7.4%). All SASC interventions with higher levels of adherence were significantly more effective (OR 1.48, 95% CI 1.20-1.84, P<.001, I2=24.5%).

Conclusions
This systematic review and meta-analysis did not support the effectiveness of delivering smartphone-based interventions alone to achieve higher smoking abstinence rates. However, the efficacy of smartphone-based interventions increased when combined with pharmacotherapy-based smoking cessation approaches.

Trial Registration
PROSPERO CRD42021267615; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267615