bluuebunny/crossref_metadata_2025_split huggingface dataset:
The photolytic breakdown of caffeine and paracetamol residues in surface water
Authors: Alhassen Haysem M. , Dyer Fiona J. , Thompson Ross M. 
Published: July 2023

AbstractHigh concentrations of the most consumed pharmaceuticals, caffeine and paracetamol, have been observed globally in wastewater treatment plant discharge. Here, we assess the potential for photodegradation of caffeine and paracetamol residues at concentrations like those observed in treated wastewater discharges to the environment. Laboratory assays were used to measure rates of photodegradation of these two compounds both in distilled water and in natural river water with leaf litter leachate. When exposed to artificial light simulating natural sunlight, the half‐life values of caffeine and paracetamol were significantly shorter than in the dark. The presence of organic matter increased caffeine and paracetamol half‐life by lessening the photolytic effect. These results suggest that photolysis is a substantial contributor to the degradation of caffeine and paracetamol. The findings contribute to our understanding of persistence of pharmaceuticals in treated wastewater discharge.Practitioner Points
The photodegradation of caffeine and paracetamol residues in surface water was examined.
With leaf litter leachate, caffeine and paracetamol were photodegraded in distilled and natural river water in laboratory.
Caffeine's half‐life ranged from 2.3 to 16.2 days under artificial sunlight andparacetamols from 4.3 to 12.2 days.
When incubated in the dark, the half‐life for both compounds exceeded 4 weeks.
Organic matter decreased the photolytic action of caffeine and paracetamol.
Trend analysis of rainfall and temperature of Ranganadi catchment with a study of the riverline shifts using satellite imagery
Authors: Kalita Ananya , Bormudoi Arnob , Singh Pranveer , Saikia Ankur Pan 
Published: July 2023

AbstractA study of trend analysis of rainfall and temperature was carried out in Ranganadi catchment which originates in the hills of Arunachal Pradesh. A nonparametric test (Mann–Kendall and Sen slope test) was employed to check the trend of both rainfall and temperature in different seasons of the year from for a period of 30 years (1990–2021). The test was applied to four stations, namely, Itanagar, Chyang Tajo, Lilabari, and NH Road Crossing covering the catchment area of Ranganadi. The test revealed a nonsignificant trend of rainfall and somewhat significant trend for temperature. The study further focused to analyze the shift and sinuosity index of the river for the years (1999–2020) with an interval of 3 years using satellite images. While the sinuosity index test failed to establish a significant change of category of the river, there were significant changes of bankline shifts, which were noticed in the same period of analysis more of random in nature. The shifting of the river added to significant social and economic problems in the study area including unemployment and population migration. It opens for a study of this temperature change to be investigated with these erratic shifts for a further analysis. This study aimed to investigate several key aspects in the floodplain of the Subansiri–Ranganadi Doab, Brahmaputra Valley, India. The research encompassed a comprehensive analysis of rainfall and temperature trends in the Ranganadi catchment area, originating from the hills of Arunachal Pradesh.
Absichten und Interesse der Arbeit
Authors: Jesacher-Rößler Livia 
Published: July 2023

ZusammenfassungMit der systemweiten Einführung der Neuen Mittelschule (NMS) ab dem Schuljahr 2012/2013 hat sich aus Schulentwicklungsperspektive eine Systemintervention in der österreichischen Schullandschaft vollzogen, die es in dieser Form noch nicht gab. Insgesamt knapp 1.300 (vgl. Statistik Austria) vormalige Hauptschulen wurden über insgesamt acht Generationen und jeweils zwei Jahre systematisch auf nationaler Ebene begleitet. Insbesondere Schulleiterinnen und Schulleiter sowie eine ausgewählte Lehrperson des Kollegiums (neue Funktion: Lerndesigner/-in) wurden in bundesweiten Lernateliers durch forschungsgeleitete Ansätze und Konzepte mit eine neuen Lern- und Lehrkultur vertraut gemacht – einer Hinwendung zu einer lernseitigen Herangehensweise sowohl auf Unterrichts- als auch auf Schulentwicklungsebene.
Erhebungsdesign und die empirische Studie im Rahmen des Projektes Modellregion Bildung Zillertal
Authors: Jesacher-Rößler Livia 
Published: July 2023

ZusammenfassungDer empirischen Untersuchung werden in dieser Arbeit zwei Aufgaben zuteil. Auf der einen Seite soll explorativ ein erweitertes Wissen über Schulleitungshandeln entwickelt werden. Auf der anderen Seite sollen die im theoretischen Teil aufgearbeiteten organisationstheoretischen Annahmen zu responsiven Akten der Schulleitenden veranschaulicht und formulierte Hypothesen modifiziert bzw. partiell überprüft werden. Damit diese beiden Aufgaben umgesetzt werden können, erfolgt zunächst eine Kontextdarstellung der Erhebung sowie in weiterer Folge eine Beschreibung der methodischen Vorgehensweise.
The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors
Authors: Verdonck-de Leeuw Irma M. , Korsten Laura H.A. , van Nieuwenhuizen Annette , Baatenburg de Jong Rob J. , Brakenhoff Ruud H. , Buffart Laurien M. , Lamers Femke , Langendijk Johannes A. , Leemans C. René , Smit Jan H. , Sprangers Mirjam A. , Takes Robert P. , Terhaard Chris H. J. , Lissenberg-Witte Birgit I. , Jansen Femke 
Published: July 2023

Abstract
Purpose
The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors.

Methods
Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment.

Results
Baseline depressive symptoms, social contacts, and oral pain were significantly associated with the course of QL from baseline to 24 months. Tumor subsite and baseline social eating, stress (hyperarousal), coughing, feeling ill, and IL-10 were associated with the course of SumSc. Post-treatment social contacts and stress (avoidance) were significantly associated with the course of QL from 6 to 24 months, and social contacts and weight loss with the course of SumSc. The course of SumSc from 6 to 24 months was also significantly associated with a change in financial problems, speech problems, weight loss, and shoulder problems between baseline and 6 months.

Conclusion
Baseline clinical, psychological, social, lifestyle, HNC-related, and biological factors are associated with the course of HRQOL from baseline to 24 months after treatment. Post-treatment social, lifestyle, and HNC-related factors are associated with the course of HRQOL from 6 to 24 months after treatment.
Experimental Study of In-medium Spectral Change of Vector Mesons at J-PARC
Authors: Aoki Kazuya , Arimizu Daichi , Ashikaga Sakiko , Chang Wen-Chen , Chujo Tatsuya , Ebata Kengo , En’yo Hideto , Esumi Shinichi , Hamagaki Hideki , Honda Ryotaro , Ichikawa Masaya , Kajikawa Shunsuke , Kanno Koki , Kimura Yuta , Kiyomichi Akio , Kondo Takehito K. , Kyan Shono , Lin Che-Sheng , Lin Chih-Hsun , Morino Yuhei , Murakami Hikari , Murakami Tomoki N. , Muto Ryotaro , Nagafusa Shunnosuke , Nakai Wataru , Nakasuga Satomi , Naruki Megumi , Nonaka Toshihiro , Noumi Hiroyuki , Ochiai Shuta , Ozawa Kyoichiro , Sakaguchi Takao , Sako Hiroyuki , Sakuma Fuminori , Sato Susumu , Sawada Shinya , Sekimoto Michiko , Shigaki Kenta , Shirotori Kotaro , Sugimura Hitoshi , Takahashi Tomonori N. , Takaura Yudai , Tatsumi Ryohei , Tsukui Kosuke , Wang Po-Hung , Yahiro Kanta , Yamaguchi Kanako H. , Yokkaichi Satoshi 
Published: July 2023

AbstractChiral symmetry and its spontaneous breaking is an essential property of the QCD vacuum and is closely related to the generation of hadron mass. J-PARC E16 experiment measures dielectron spectra in p+A collisions at 30 GeV to study the in-medium spectral change of vector mesons that signals the partial restoration of the broken symmetry. The experiment uses the primary proton beam available at the high-momentum beam line of the J-PARC hadron experimental facility. We performed three proton-beam runs intended for beamline and detector commissioning. We are preparing for the next commissioning run in 2023 and the first physics run. We present the experimental setup, some of the expected results, preparation status, and some findings in the commissioning runs.
Technological knowledge and wages: from skill premium to wage polarization
Authors: Afonso Oscar , Sequeira Tiago , Almeida Derick 
Published: July 2023

AbstractThis paper studies the impact of automation shocks on the technological-knowledge level, skill premium (or wage inequality), real prices, output, and economic growth. To highlight the economic mechanisms, we devise a task-based direct technical change model that allows us to analyze the determinants of the threshold task, the relative output and prices between sectors, intra- and inter-sectoral wage differences, wage polarization and economic growth rates. We observe that an increase in the efficiency of skilled or unskilled workers as well as a decrease in the efficiency of medium-skilled workers as possible result of automation always increase wage polarization as well as economic growth rates. In a quantitative exercise we also assess the change in the weight of routine and non-routine sectors in the economy. In this context, governments should implement policies to support the professional transition of medium-skilled workers to non-routinazable tasks.
Phosphorus recovery methods from secondary resources, assessment of overall benefits and barriers with focus on the Nordic countries
Authors: Hosseinian Aida , Pettersson Anita , Ylä-Mella Jenni , Pongrácz Eva 
Published: July 2023

AbstractPhosphorus (P) recovery and recycling play a crucial role in improving resource efficiency, sustainable nutrient management and moving toward circular economy. Increasing demand for fertilizers, signs of geopolitical constraints, and high discharge of P to waterbodies are the other reasons to pursue the circularity of P. Various research have been carrying out and several processes have been developed for P-recovery from different resources. However, there is still a huge unexplored potential for P-recovery specially in the regional framework from the four main P-rich waste resources: food waste, manure, mining waste, and sewage sludge. This study reviews recovery methods of P from these secondary resources comprehensively. Additionally, it analyzes the Nordic viewpoint of P-cycle by evaluating Nordic reserves, demands, and secondary resources to gain a systematic assessment of how Nordic countries could move toward circular economy of P. Results of this study show that secondary resources of P in Nordic countries have the potential of replacing mineral fertilizer in these countries to a considerable extent. However, to overcome the challenges of P-recovery from studied resources, policymakers and researchers need to take decisions and make innovation along each other to open the new possibilities for Nordic economy.
Reporting in large-scale agile organizations: insights and recommendations from a case study in software development
Authors: Schüll Moritz , Hofmann Peter , Philipp Pascal , Urbach Nils 
Published: July 2023

AbstractApplication of agile software development methodologies in large-scale organizations is becoming increasingly common. However, working with multiple teams and on multiple products at the same time yields higher coordination and communication efforts compared to single-team settings for which agile methodologies have been designed originally. With the introduction of agile methodologies at scale also comes the need to be able to report progress and performance not only of individual teams but also on higher aggregation of products and portfolios. Due to faster iterations, production of intermediate work results, increased autonomy of teams, and other novel characteristics, agile methodologies are challenging existing reporting approaches in large organizations. Based on 23 interviews with 17 practitioners from a large German car manufacturing company, this case study investigates challenges with reporting in large-scale agile settings. Further, based on insights from the case study, recommendations are derived. We find that combining reporting and agile methodologies in large-scale settings is indeed challenging in practice. Our research contributes to the understanding of these challenges, and points out opportunities for future research to improve reporting in large-scale agile organizations by goal-setting and automation.
Modeling hemp as an innovative input: an application of the diffusion of innovations in a sample of hemp aware consumers
Authors: Lacasse Hannah , Kolodinsky Jane , Reynolds Travis , Darby Heather 
Published: July 2023

AbstractAfter decades of absence, the federal legalization of hemp in the U.S. positions the crop as an innovative, plant-based input for conventional products. Through an application of the diffusion of innovations theory, this study responds to identified research needs made by hemp stakeholders and the existing literature by modeling the influence of innovation characteristics on propensity to use hemp products among Vermont consumers. Findings reveal that attributes associated with relative advantage and trialability significantly influence propensity to use at least one type of hemp product, as well as use multiple types of hemp products. This highlights particularly salient points for hemp stakeholders engaged in the marketing and communication of hemp products. Findings contribute to informed strategy creation for producers, institutions, and other stakeholders operating in this nascent industry, where data and research continue to be limited.
Perception and acceptance of robots in dairy farming—a cluster analysis of German citizens
Authors: Langer Greta , Kühl Sarah 
Published: July 2023

AbstractSocietal attitude acceptance can influence the digital transformation in agriculture. Digital technologies, such as robots in dairy farming, can lead to more sustainable, animal welfare-friendly and consumer-oriented milk production. This study used the example of the milking and feeding robots to investigate whether society accepts the use of robots in dairy farming and whether there are differences in society based on perceived risks and opportunities of digitalization in dairy farming and acceptance. To this end, an online-based study was conducted with a total of 1007 citizens in Germany. Overall, the respondents in this study suspect that the use of robots in dairy farming is associated with various risks but also with opportunities for society and for farmers in particular. However, these attitudes are quite heterogeneous. Four clusters could be identified: “proponents of robots”, “indifferent citizens”, “skeptical citizens”, and “critical supporters of robots”. Proponents of robots see only opportunities and little risks, whereas the critical citizens perceive not only opportunities but also many risks of using robots in dairy farming. The indifferent citizens show a rather indifferent attitude, in contrast to the skeptical citizens, who reject the opportunities at the societal level, while they agree with the opportunities of robots for farmers. This research contributes to understanding societal attitudinal acceptance and highlights differences in society that can help inform future decisions about the development and adoption of robots in dairy farming.
The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4
Authors: Chen Wenhu , Hu Liqiang , Lu Xuemei , Wang Xiaofei , Zhao Changan , Guo Chen , Li Xiaoyan , Ding Yuqin , Zhao Hongguang , Tong Dongdong , Wang Lifang , Huang Chen 
Published: July 2023

Abstract
Purpose
Breast cancer (BC) is the most frequent malignant tumor in women worldwide with exceptionally high morbidity. The RNA-binding protein MEX3A plays a crucial role in genesis and progression of multiple cancers. We attempted to explore its clinicopathological and functional significance in BC in which MEX3A is expressed.

Methods
The expression of MEX3A detected by RT-qPCR and correlated the results with clinicopathological variables in 53 BC patients. MEX3A and IGFBP4 profile data of BC patients were downloaded from TCGA and GEO database. Kaplan-Meier (KM) analysis was used to estimate the survival rate of BC patients. Western Blot, CCK-8, EdU, colony formation and flow cytometry were performed to investigate the role of MEX3A and IGFBP4 in BC cell proliferation, invasion and cell cycle in vitro. A subcutaneous tumor mouse model was constructed to analyze in vivo growth of BC cells after MEX3A knockdown. The interactions among MEX3A and IGFBP4 were measured by RNA pull-down and RNA immunoprecipitation.

Results
The expression of MEX3A was upregulated in BC tissues compared to adjacent tissues and high expression of MEX3A was associated with poor prognosis. Subsequent in vitro studies demonstrated that MEX3A knockdown inhibited BC cells proliferation and migration, as well as xenograft tumor growth in vivo. The expression of IGFBP4 was significantly negatively correlated with MEX3A in BC tissues. Mechanistic investigation showed that MEX3A binds to IGFBP4 mRNA in BC cells, decreasing IGFBP4 mRNA levels, which further activated the PI3K/AKT and other downstream signaling pathways implicated cell cycle progression and cell migration.

Conclusion
Our results indicate that MEX3A plays a prominent oncogenic role in BC tumorigenesis and progression by targeting IGFBP4 mRNA and activating PI3K/AKT signaling, which can be used as a novel therapeutic target for BC.
The Digital Transformation of Instructional Materials. Views and Practices of Teachers, Families and Editors
Authors: Area-Moreira Manuel , Rodríguez-Rodríguez Jesús , Peirats-Chacón José , Santana-Bonilla Pablo 
Published: July 2023

AbstractThe purpose of this article is to present the design and main findings of a three-year study analyzing the transition from printed to digital educational materials for primary education in Spain. Special attention has been given to the metamorphosis of didactic materials in the context of the digital society. The research focused on two issues: (a) the opinion of educational agents regarding digital educational material, and (b) the use made of digital educational materials in schools and classrooms. Two different but complementary studies were designed and carried out. The first explored the perspectives or subjectivities of educational agents—teachers, material creators and families. The second was a multi-case study involving several schools and analyzing the educational use of materials by teachers. Our findings indicate that the dissemination of digital educational materials is carried out through both paid commercial platforms and public access platforms promoted by educational administrations and that an expository teaching model underlies most online teaching materials. Educational agents have high expectations and a positive predisposition towards digital resources. Likewise, it has been found that teachers make functional and hybrid didactic adaptations of digital resources. Finally, it is suggested that the study’s approach and methodology have potential for extrapolation to other national contexts.
Multidimensional measure of employability: internal structure and associations with motivational and emotional features in unemployed persons
Authors: Silva Ana Daniela , Carvalho Catarina Luzia , Coscioni Vinicius , Soares Joana , Taveira Maria do Céu 
Published: July 2023

AbstractThis study describes validity and reliability evidence of the Multidimensional Measure of Employability (MME) based on the internal structure and relations to other measures in a sample of unemployed persons in Portugal. Altogether, 216 individuals participated in an online survey. The MME’s internal structure was tested by confirmatory factor analyses, suggesting good fit. The factors’ reliability was good, as assessed by four types of coefficients. Multiple linear regressions considering motivational and emotional features allowed for the identification of validity evidence based on the relationships with other constructs. Thus, MME is a valid and reliable measure to assess employability among unemployed persons.
Efficient room temperature carbon dioxide gas sensor based on barium doped CuO thin films
Authors: Abdelkarem Khaled , Saad Rana , Ahmed Ashour M. , Fathy M. I. , Shaban Mohamed , Hamdy Hany 
Published: July 2023

AbstractFor a safe environment, harmful-gas sensors of low cost and high performance are essential. For CO2 gas sensing applications, Ba-doped CuO thin films with 4 mol% and 6 mol% Ba were produced on glass substrates using the successive ionic layer adsorption and reaction approach. Utilizing various techniques, crystallographic structures, nanomorphologies, and elemental compositions were examined to assess the impact of doping on the characteristics of the films. According to the structural and morphological analyses, the nanocrystalline films consisted of irregularly shaped nanoparticles, which assembled to form a rough surface with unequal grain sizes. Because of its nanoporous nature, the CuO:6% Ba thin film exhibited the most substantial nanomorphological change and the highest gas sensing capability. At varied CO2 gas flow rates, the maximum sensor response (9.4%) and Rair/RCO2 ratio (1.12) at room temperature (RT = 30 °C) were observed at 100 SCCM. By optimizing the sensor’s operating temperature, the sensor response value reached 82.2% at 150 °C, which is approximately eight times the value at RT. Selectivity, reusability, repeatability, detection limit, and quantification limit were all tested. It shows excellent response and recovery times of 5.6 and 5.44 s. In comparison to prior literature, the improved sensor is suited for use in industrial applications.

Graphical abstract
Chronic Granulomatous Disease: a Cohort of 173 Patients—10-Years Single Center Experience from Egypt
Authors: Abd Elaziz Dalia , EL Hawary Rabab , Meshaal Safa , Alkady Radwa , Lotfy Sohilla , Eldash Alia , Erfan Aya , Chohayeb Engy , Saad Mai , Boutros Jeannette , Galal Nermeen , Elmarsafy Aisha 
Published: July 2023

Abstract
Purpose
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder of phagocytes, characterized by recurrent fungal and bacterial infections. Our aim is to describe the different clinical presentations, non-infectious auto-inflammatory features, types and sites of infections, and to estimate the mortality among our large cohort.

Methods
This is a retrospective study conducted at the Pediatric Department of Cairo University Children’s Hospital in Egypt, including cases with a confirmed CGD diagnosis.

Results
One hundred seventy-three confirmed CGD patients were included. AR-CGD was diagnosed in 132 patients (76.3%) including 83 patients (48%) with p47phox defect, 44 patients (25.4%) with p22phox defect, and 5 patients (2.9%) with p67phox defect. XL-CGD was diagnosed in 25 patients (14.4%). The most common recorded clinical manifestations were deep-seated abscesses and pneumonia. Gram-negative bacteria and Aspergillus were the most frequently isolated species. Regarding the outcome, 36 patients (20.8%) were lost from follow-up. Among patients with known outcome, 94/137 patients (68.6%) are living, while 43/137 patients (31.4%) died.

Conclusion
AR-CGD is predominant in Egypt; CGD must always be ruled out in any patient presenting with typical or atypical mycobacterial or BCG-disease.