bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can a 5-to-90-day Mortality Predictor Perform Consistently Across Time and Equitably Across Populations?
Authors: Handler Jonathan , Lee Olivia J. , Chatrath Sheena , McGarvey Jeremy , Fitch Tyler , Jose Divya , Vozenilek John 
Published: July 2023

AbstractAdvance care planning (ACP) facilitates end-of-life care, yet many die without it. Timely and accurate mortality prediction may encourage ACP. However, performance of predictors typically differs among sub-populations (e.g., rural vs. urban) and worsens over time (“concept drift”). Therefore, we assessed performance equity and consistency for a novel 5-to-90-day mortality predictor across various demographies, geographies, and timeframes (n = 76,812 total encounters). Predictions were made for the first day of included adult inpatient admissions on a retrospective dataset. AUC-PR remained at 29% both pre-COVID (throughout 2018) and during COVID (8 months in 2021). Pre-COVID-19 recall and precision were 58% and 25% respectively at the 12.5% certainty cutoff, and 12% and 44% at the 37.5% cutoff. During COVID-19, recall and precision were 59% and 26% at the 12.5% cutoff, and 11% and 43% at the 37.5% cutoff. Pre-COVID, compared to the overall population, recall was lower at the 12.5% cutoff in the White, non-Hispanic subgroup and at both cutoffs in the rural subgroup. During COVID-19, precision at the 12.5% cutoff was lower than that of the overall population for the non-White and non-White female subgroups. No other significant differences were seen between subgroups and the corresponding overall population. Overall performance during COVID was unchanged from pre-pandemic performance. Although some comparisons (especially precision at the 37.5% cutoff) were underpowered, precision at the 12.5% cutoff was equitable across most demographies, regardless of the pandemic. Mortality prediction to prioritize ACP conversations can be provided consistently and equitably across many studied timeframes and sub-populations.
Conservation of all Lipkin’s zilches from symmetries of the standard electromagnetic action and a hidden algebra
Authors: Letsios Vasileios A. 
Published: July 2023

AbstractIn 1964, Lipkin discovered the zilches, a set of conserved quantities in free electromagnetism. Among the zilches, optical chirality was identified by Tang and Cohen in 2010, serving as a measure of the handedness of light and leading to investigations into light’s interactions with chiral matter. While the symmetries underlying the conservation of the zilches have been examined, the derivation of zilch conservation laws from symmetries of the standard free electromagnetic (EM) action using Noether’s theorem has only been addressed in the case of optical chirality. We provide the full answer by demonstrating that the zilch symmetry transformations of the four-potential, $$A_{\mu }$$

A
μ

, preserve the standard free EM action. We also show that the zilch symmetries belong to the enveloping algebra of a “hidden” invariance algebra of free Maxwell’s equations. This “hidden” algebra is generated by familiar conformal transformations and certain “hidden” symmetry transformations of $$A_{\mu }$$

A
μ

. Generalizations of the “hidden” symmetries are discussed in the presence of a material four-current, as well as in the theory of a complex Abelian gauge field. Additionally, we extend the zilch symmetries of the standard free EM action to the standard interacting action (with a non-dynamical four-current), allowing for a new derivation of the continuity equation for optical chirality in the presence of electric charges and currents. Furthermore, new continuity equations for the remaining zilches are derived.
Identification of potential Akt activators: a ligand and structure-based computational approach
Authors: Kumar Harish B. , Manandhar Suman , Rathi Ekta , Kabekkodu Shama Prasada , Mehta Chetan Hasmukh , Nayak Usha Yogendra , Kini Suvarna G. , Pai K. Sreedhara Ranganath 
Published: July 2023

AbstractThe Akt pathway plays a significant role in various diseases like Alzheimer’s, Parkinson’s, and Diabetes. Akt is the central protein whose phosphorylation controls many downstream pathways. Binding of small molecules to the PH domain of Akt facilitates its phosphorylation in the cytoplasm and upregulates the Akt pathway. In the current study, to identify Akt activators, ligand-based approaches like 2D QSAR, shape, and pharmacophore-based screening were used, followed by structure-based approaches such as docking, MM-GBSA, ADME prediction, and MD simulation. The top twenty-five molecules from the Asinex gold platinum database found to be active in most 2D QSAR models were used for shape and pharmacophore-based screening. Later docking was performed using the PH domain of Akt1 (PDB: 1UNQ), and 197105, 261126, 253878, 256085, and 123435 were selected based on docking score and interaction with key residues, which were druggable and formed a stable protein–ligand complex. MD simulations of 261126 and 123435 showed better stability and interactions with key residues. To further investigate the SAR of 261126 and 123435, derivatives were downloaded from PubChem, and structure-based approaches were employed. MD simulation of derivatives 12289533, 12785801, 83824832, 102479045, and 6972939 was performed, in which 83824832 and 12289533 showed interaction with key residues for a longer duration of time, proving that they may act as Akt activators.
Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma
Authors: Feng Huajun , Zhao Feipeng , Luo Jian , Xu Shengen , Liang Zhuoping , Xu Wei , Bao Yilin , Qin Gang 
Published: July 2023

Abstract
Background
The long non-coding RNA HOXA transcript at the distal tip (HOTTIP) and homeobox A13 (HOXA13) have been identified as oncogenes that play a pivotal role in tumorigenesis. However, their specific mechanisms of action in nasopharyngeal carcinoma (NPC) progression remain unclear.

Methods and results
In the present study, RT-qPCR was employed to quantify RNA expression in NPC cells and tissues. Flow cytometry, MTT, CCK8 and colony formation assays were utilized to assess cell apoptosis and proliferation. Transwell assay was conducted to evaluate migration and invasion while Western blotting was performed for protein expression analysis. Our findings revealed that the expression of HOTTIP was significantly upregulated in NPC cell lines. Inhibition of HOTTIP could induce apoptosis and suppress proliferation, clonogenicity, invasion and metastasis in NPC cells. Knockdown of HOTTIP led to downregulation of HOXA13 expression, which subsequently inhibited the proliferation and metastasis in NPC cells. The inhibitory effects on cell proliferation and metastasis caused by HOTTIP silencing were rescued by HOXA13 overexpression. Additionally, there was a significant positive correlation between HOTTIP and HOXA13, which were found to be elevated in NPC tissues compared to normal tissues.

Conclusions
We have determined that LncRNA HOTTIP facilitates tumorigenesis by modulating the expression of HOXA13 in NPC cells. Targeting HOTTIP/HOXA13 may be a promising therapeutic strategy for NPC.
Palmprint enhancement network (PEN) for robust identification
Authors: Mehmood Ahmed Bilal , Taj Imtiaz A. , Ghafoor Mubeen 
Published: July 2023

AbstractDespite being reliable, palmprints have not received as much attention as other biometrics such as fingerprints, face or iris. Amount of information provided by high resolution palmprints and the fact that they have huge forensic value makes them a preferred biometric choice for large scale identification systems. In palmprints, extraction of reliable features for identification is still a challenging task especially because most of palmprints found in the real world, e.g., in crime scenes, are of poor quality. This makes palmprint enhancement a crucial pre cursor to identification. Errors during enhancement result in extraction of un-reliable features which deteriorate identification accuracy. Recent works in palmprints have focused more on matching algorithms and limited novelty has been introduced in enhancement. Enhancement techniques used on high resolution palmprints recently are either borrowed from fingerprint techniques or are built on the high-risk assumption that palm ridge pattern is stationary or smooth in a local area. Large size and abruptly changing ridge pattern of palmprints dictates the need for a more robust enhancement scheme. This paper proposes a novel deep learning based high resolution palmprint enhancement approach that is able to process large areas of palmprint without making the assumption that underlying ridge pattern is stationary. We have tested proposed enhancement approach on a renowned high resolution palmprint dataset which shows that proposed technique performs favourably in comparison to state of the art.
Non-trivial solutions and their stability in a two-degree-of-freedom Mathieu–Duffing system
Authors: Barakat Ahmed A. , Weig Eva M. , Hagedorn Peter 
Published: July 2023

AbstractThe Mathieu–Duffing equation represents a basic form for a parametrically excited system with cubic nonlinearities. In multi-degree-of-freedom systems, parametric resonances and the associated limit cycles take place at both principal and combination resonance frequencies. Furthermore, using asynchronous parametric excitation of coupling terms leads to a broadband destabilization of the trivial solution and the appearance of limit cycles at non-resonant frequencies. Regarding applications, the utilization of this excitation method has its significant importance in micro- and nanosystems. On the one hand, cubic nonlinearities are found to be abundant in these systems. On the other hand, parametric excitation is preferably utilized in these systems for better amplification leading to an enhanced sensitivity and for squeezing thermal noise, and thus, proved to be significantly useful in mechanical, optical and microwave systems. Therefore, this theoretical investigation should be of relevant importance to those small-scaled systems. Accordingly, a general two-degree-of-freedom Mathieu–Duffing system is studied. The non-trivial solutions are obtained at different parametric resonance conditions. A bifurcation analysis is carried out using the multiple scales method, followed by investigating the effect of the asynchronous parametric excitation on the existence of limit cycles at resonant and non-resonant frequencies.
Agronomic management strategies to increase soil organic carbon in the short-term: evidence from on-farm experimentation in the Veneto region
Authors: Giannini Vittoria , Raimondi Giorgia , Toffanin Arianna , Maucieri Carmelo , Borin Maurizio 
Published: July 2023

Abstract
Background and aims
Organic fertilizers and cover crops (CC) are considered crucial strategies to pursue the objective of increasing soil organic carbon (SOC). The present research focuses on an ‘on farm experimentation’ to assess the combined effects of organic fertilization with different biomasses, CC and irrigation on SOC stock.

Methods
A 4-year on-farm experimentation was co-developed with local farmers and a land reclamation authority in north-eastern Italy on a biennial maize-soybean rotation. We examined the effects of two organic fertilizers (compost or digestate), three CC treatments (a fixed cover crop species – x triticosecale; a succession of cover crop species – Sinapis alba and Lolium multiflorum; no CC) under rainfed and irrigated conditions on the SOC content and stock, and crops yields.

Results
All these integrated practices – except when digestate was applied in the field in the absence of a CC under rainfed conditions – determined a significant increase of the SOC stock after 4 years, matching the goals set by the ‘4 per mille’ initiative. The highest SOC increase was observed under irrigated management and compost fertilization, regardless of the presence or absence of a CC (range: 9.3–10.3 Mg ha−1 in the first 0–40 cm of soil). Soybean grain yields were comparable with those obtained in farms of the same rural district under business as usual, but maize grain yields were lower.

Conclusion
SOC accumulation is achievable in the short term with abundant applications of organic biomass, but the strategy might lead to economic loss such as lower maize productivity.
On the Individuation of Laws and the Interpretation-Construction Distinction
Authors: Matczak Marcin 
Published: July 2023

AbstractThe problem of the individuation of laws, identified by Bentham, is dismissed as irrelevant to legal philosophy by some commentators. This paper presents individuation as crucial for understanding the cognitive processes underlying legal interpretation. It draws on the work of Maciej Zieliński and Teun van Dijk to show that legal interpretation is based on deriving legal rules qua semantic macrostructures from a legal text treated as a complex discourse. The Zieliński/van Dijk model also lends theoretical support to the interpretation-construction distinction by explaining, in linguistic terms, the processes that take place during construction.
Evaluation of Toxicological Effects of ZnO and CuO Nanoparticles with Taraxacum officinale as Bioindicator
Authors: Abrica-González Paulina , Gómez-Arroyo Sandra , Jazcilevich-Diamant Arón , Sotelo-López Antonio , Flores-Márquez Ana Rosa , Cortés-Eslava Josefina 
Published: July 2023

Abstract
Nanoparticles are rising worries because of recent reports about potential toxicity amid the incorporation of these emerging materials into consumer products, and industrial and scientific applications. New developments in the automotive industry are incorporating novel materials, which have increased the emission of nanoparticles into the atmosphere. To overcome the difficulty of detecting and characterizing atmospheric nanoparticles, alternative methods have been proposed, just as the indirect detection and characterization with bioindicators. We report the use of Taraxacum officinale as a sentinel organism to describe the effects of atmospheric nanostructured pollutants. ZnO and CuO nanoparticles (ZnO-NPs, CuO-NPs) were selected for this study, as they are two of the most present nanomaterials in the emerging automotive industry. The physiological effect on Taraxacum officinale exposure to ZnO-NPs and CuO-NPs was evaluated through growth rate, and total chlorophyll content; and comet assay was performed to evaluate the DNA damage. The exposure of plants was made by nebulizing dispersions of the nanoparticles. The exposure to ZnO-NPs presented the maximum DNA damage at a concentration of 100 mg/L. The DNA damage by both studied nanoparticles showed a significant difference against its bulk counterparts. Scanning electron microscopy (SEM) micrographs showed an accumulation of nanoparticles near the stomata. The study demonstrated the feasibility of T. officinale as a bioindicator of air-related nanoparticles toxicity, and the high sensitivity of the comet assay for this approach.
Correlating the succession of microbial communities from Nigerian soils to petroleum biodegradation
Authors: Iturbe-Espinoza Paul , Bonte Matthijs , Weedon James T , Braster Martin , Brandt Bernd W , van Spanning Rob JM 
Published: July 2023

AbstractWhilst biodegradation of different hydrocarbon components has been widely demonstrated to occur by specialist oil-degrading bacteria, less is known about the impact on microbial communities as a function of oil composition by comparing the biodegradation of chemically complex fuels to synthetic products. The objectives of this study were (i) to assess the biodegradation capacity and succession of microbial communities isolated from Nigerian soils in media with crude oil or synthetic oil as sole sources of carbon and energy, and (ii) to assess the temporal variability of the microbial community size. Community profiling was done using 16 S rRNA gene amplicon sequencing (Illumina), and oil profiling using gas chromatography. The biodegradation of natural and synthetic oil differed probably due to the content of sulfur that may interfere with the biodegradation of hydrocarbons. Both alkanes and PAHs in the natural oil were biodegraded faster than in the synthetic oil. Variable community responses were observed during the degradation of alkanes and more simple aromatic compounds, but at later phases of growth they became more homogeneous. The degradation capacity and the size of the community from the more-contaminated soil were higher than those from the less-contaminated soil. Six abundant organisms isolated from the cultures were found to biodegrade oil molecules in pure cultures. Ultimately, this knowledge may contribute to a better understanding of how to improve the biodegradation of crude oil by optimizing culturing conditions through inoculation or bioaugmentation of specific bacteria during ex-situ biodegradation such as biodigesters or landfarming.
Impact of agronomic practices on physical surface crusts and some soil technical attributes of two winter wheat fields in southern Iraq
Authors: Al-Shammary Ahmed Abed Gatea , Al-Shihmani Layth Saleem Salman , Caballero-Calvo Andrés , Fernández-Gálvez Jesús 
Published: July 2023

Abstract
Purpose
Agricultural management as tillage systems and manure application can contribute effectively to controlling physical surface crusts (SCs), improving the soil’s technical characteristics and germination rates. While agronomic practices are generally applied to winter wheat fields in southern Iraq, no previous study has explored their impact in combination with SCs and soil physical attributes on wheat productivity (WP) under different soil textures.

Materials and methods
The impact of different agronomic management practices on the formation of soil physical surface crusts (SCs), soil compaction (measured by soil penetration resistance, SPR), soil volumetric water content (VWC), soil bulk density (ρb), mean weight diameter of aggregates (MWD), and WP was examined in two soil textures (clay loam, clay) during 2020 and 2022.
Experimental data were subjected to an identical and randomized complete block design (RCBD) under a nested-factorial experimental design, where nine treatments with three replicates each were selected. This included three tillage practices (conventional tillage system (CT), till-plant (TP), and rotational tillage (NTCT)), alongside a sub-treatment with organic fertilizers (cattle manure (CF), and wheat straw (WR)), or without added fertilizer (WT).

Results and discussion
Results showed that CT treatment increased SCs during wheat growth stages by significantly increasing aggregate stability. A significant difference in ρb and SPR and a higher distribution of VWC were seen under CT treatment when compared to TP and NTCT treatments. TP treatment showed a significantly increased in SPR and ρb, particularly in clay loam. The MWD under TP and NTCT was significantly different to CT treatment, which may be explained by an increase in soil stability due to their management practices. Additionally, both organic fertilizers (CF and WR) significantly enhanced SCs, SPR, VWC, ρb, MWD, and WP.

Conclusions
These data showed a strong relationship between SCs and ρb and between VWC and SPR, which are directly affected by the soil’s water content.
Securities transaction taxes and stock price informativeness: evidence for France and Italy
Authors: da Silva Paulo Pereira 
Published: July 2023

AbstractThis empirical study addresses the impact of securities transaction taxes (STTs) on price informativeness. Two specific events are assessed: the entry into force of STTs in France and Italy in 2012 and 2013, respectively. Specifically, it is gauged whether those events produced effects on the future earnings response coefficient (FERC)—a proxy for the capacity of investors to anticipate future earnings—of the stocks eligible for the STT. Our findings indicate that the new taxes on securities transactions that entered into force in France and Italy were neutral with respect to the effects on price informativeness. That is, no material changes in the FERC of affected stocks are detected in the aftermath of the STTs’ entry into force. This result applies when considering the events in France and Italy separately, and when analyzing different subsets of the sample based on the size, trading activity, and liquidity of the stocks.
28 months later: the coronavirus pandemic as an analogy for future sustainability challenges
Authors: Engler John-Oliver , von Wehrden Henrik 
Published: July 2023

AbstractWe combine the concepts of ‘black elephants’ and wicked problems with Roy Bhaskar’s critical realist philosophy of science and frame the current state of the coronavirus pandemic as an analogy for impending sustainability challenges. We point out and illustrate that the interaction of different ontological levels of our world as it ‘is’ will likely remain a challenge in addressing the wicked problems of our time.
Evolving and generalising morphologies for locomoting micro-scale robotic agents
Authors: Uppington Matthew , Gobbo Pierangelo , Hauert Sabine , Hauser Helmut 
Published: July 2023

AbstractDesigning locomotive mechanisms for micro-scale robotic systems could enable new approaches to tackling problems such as transporting cargos, or self-assembling into pre-programmed architectures. Morphological factors often play a crucial role in determining the behaviour of micro-systems, yet understanding how to design these aspects optimally is a challenge. This paper explores how the morphology of a multi-cellular micro-robotic agent can be optimised for reliable locomotion using artificial evolution in a stochastic environment. We begin by establishing the theoretical mechanisms that would allow for collective locomotion to emerge from contractile actuations in multiple connected cells. These principles are used to develop a Cellular Potts model, in order to explore the locomotive performance of morphologies in simulation. Evolved morphologies yield significantly better performance in terms of the reliability of the travel direction and the distance covered, compared to random morphologies. Finally, we demonstrate that patterns in evolved morphologies are robust to small imperfections and generalise well to larger morphologies.
Six inertial measurement unit-based components describe wheelchair mobility performance during wheelchair tennis matches
Authors: Rietveld Thomas , Vegter Riemer J. K. , van der Slikke Rienk M. A. , Hoekstra Aldo E. , van der Woude Lucas H. V. , de Groot Sonja 
Published: July 2023

AbstractThe aim of this explorative study was to determine the key inertial measurement unit-based wheelchair mobility performance components during a wheelchair tennis match. A total of 64 wheelchair tennis matches were played by 15 wheelchair tennis players (6 women, 5 men, 4 juniors). All individual tennis wheelchairs were instrumented with inertial measurement units, two on the axes of the wheels and one on the frame. A total of 48 potentially relevant wheelchair tennis outcome variables were initially extracted from the sensor signals, based on previous wheelchair sports research and the input of wheelchair tennis experts (coaches, embedded scientists). A principal component analysis was used to reduce this set of variables to the most relevant outcomes for wheelchair tennis mobility. Results showed that wheelchair mobility performance in wheelchair tennis can be described by six components: rotations to racket side in (1) curves and (2) turns; (3) linear accelerations; (4) rotations to non-racket side in (4) turns and (5) curves; and finally, (6) linear velocities. One or two outcome variables per component were selected to allow an easier interpretation of results. These key outcome variables can be used to adequately describe the wheelchair mobility performance aspect of wheelchair tennis during a wheelchair tennis match and can be monitored during training.