bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing back of relapse clones by Ig/TCR gene rearrangements reveals complex patterns of recurrence in pediatric acute lymphoblastic leukemia
Authors: Jia Ming‐Zhu , Li Wei‐Jing , Wang Chan‐Juan , Zhang Qing , Gao Chao , Huang Xiao‐Tong , Zhu Ting , Zhang Rui‐Dong , Cui Lei , Li Zhi‐Gang 
Published: May 2023

AbstractIntroductionRelapse remained the major obstacle to improving the prognosis of children with acute lymphoblastic leukemia (ALL). This study aimed to investigate the changing patterns of Ig/TCR gene rearrangements between diagnosis and relapse and the clinical relevance and to explore the mechanism of leukemic relapse.MethodsClonal Ig/TCR gene rearrangements were screened by multiplex PCR amplification in 85 paired diagnostic and relapse bone marrow (BM) samples from children with ALL. The new rearrangements presented at relapse were quantitatively assessed by the RQ‐PCR approach targeting the patient‐specific junctional region sequence in 19 diagnostic samples. The relapse clones were further back‐traced to diagnostic and follow‐up BM samples from 12 patients.ResultsComparison of Ig/TCR gene rearrangements between diagnosis and relapse showed that 40 (57.1%) B‐ALL and 5 (33.3%) T‐ALL patients exhibited a change from diagnosis to relapse, and 25 (35.7%) B‐ALL patients acquired new rearrangements at relapse. The new relapse rearrangements were present in 15 of the 19 (78.9%) diagnostic samples as shown by RQ‐PCR, with a median level of 5.26 × 10−2. The levels of minor rearrangements correlated with B immunophenotype, WBC counts, age at diagnosis, and recurrence time. Furthermore, back‐tracing rearrangements in 12 patients identified three patterns of relapse clone dynamics, which suggested the recurrence mechanisms not only through clonal selection of pre‐existing subclones but also through an ongoing clonal evolution during remission and relapse.ConclusionBacktracking Ig/TCR gene rearrangements in relapse clones of pediatric ALL revealed complex patterns of clonal selection and evolution for leukemic relapse.
Clinical outcomes of COVID‐19 treated with remdesivir across the continuum of care
Authors: Rivera Christina G. , Chesdachai Supavit , Draper Evan W. , Arndt Richard F. , Mara Kristin C. , Gonzalez Suarez Maria , Razonable Raymund R. 
Published: May 2023

AbstractIntroductionDuring the early phase of the coronavirus disease 2019 (COVID‐19), remdesivir was only approved for hospitalized patients. Our institution developed hospital‐based, outpatient infusion centers for selected hospitalized patients with COVID‐19 who had clinical improvement to allow for early dismissal. The outcomes of patients who transitioned to complete remdesivir in the outpatient setting were examined.MethodsRetrospective study of all hospitalized adult patients with COVID‐19 who received at least one dose of remdesivir from November 6, 2020, to November 5, 2021, at one of the Mayo Clinic hospitals.ResultsAmong 3029 hospitalized patients who received treatment with remdesivir for COVID‐19, the majority (89.5%) completed the recommended 5‐day course. Among them, 2169 (80%) patients completed treatment during hospitalization, whereas 542 (20.0%) patients were dismissed to complete remdesivir in outpatient infusion centers. Patients who completed the treatment in the outpatient setting had lower odds of death within 28 days (aOR 0.14, 95% CI 0.06–0.32, p < 0.001). However, their rate of subsequent hospital encounters within 30 days was higher (aHR 1.88, 95% CI 1.27–2.79, p = 0.002). Among patients treated with remdesivir only in the inpatient setting, the adjusted odds of death within 28 days were significantly higher among those who did not complete the 5‐day course of remdesivir (aOR 2.07, 95% CI 1.45–2.95, p < 0.001).ConclusionsThis study describes the clinical outcomes of a strategy of transitioning remdesivir therapy from inpatient to outpatient among selected patients. Mortality was lower among patients who completed the 5‐day course of remdesivir.
Effect of single‐port video‐assisted thoracoscopy on surgical site wound infection and healing in patients with lung cancer: A meta‐analysis
Authors: Wu Wenqi , Zhao Yan , Zhang Zhe , Jiang Jingyuan , Feng Chong , Qin Dongliang , Zhang Chen , Xu Zhenan , Zhang Lening , Lin Fengwu 
Published: May 2023

AbstractWe performed a meta‐analysis to comprehensively assess the effect of single‐port video‐assisted thoracoscopy on surgical site wound infection and healing in patients with lung cancer. A computerised search for studies on single‐port video‐assisted thoracoscopy treatment of lung cancer was conducted from the time of database creation through February 2023 using the PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases. Two investigators independently screened the literature, extracted information, and evaluated the quality of studies according to inclusion and exclusion criteria. Either a fixed or random‐effects model was used in calculating the relative risk (RR) with 95% confidence intervals (CIs). Meta‐analysis was performed using RevMan 5.4 software. The results showed that, compared with multi‐port video‐assisted thoracoscopy, single‐port video‐assisted thoracoscopy significantly reduced surgical site wound infection (RR: 0.38, 95% CI: 0.19–0.77, P = .007) and significantly promoted wound healing (RR: 0.37, 95% CI: 0.22–0.64, P < .001). Compared with multi‐port video‐assisted thoracoscopy, single‐port video‐assisted thoracoscopy significantly reduced surgical site wound infections and also promoted wound healing. However, because of large variations in study sample sizes, some of the literature reported methods of inferior quality. Additional high‐quality studies containing large sample sizes are needed to further validate these results.
‘Being a part of something’: Experiences and perceived benefits of young adult peer mentors with intellectual/developmental disabilities and co‐occurring mental health conditions
Authors: Loeper Tara , Schwartz Ariel E. 
Published: May 2023

AbstractBackgroundPeer‐provided services are a common model for addressing mental health concerns. Peer providers report a range of benefits and challenges associated with their role. However, there is little information about the experiences of peer providers with intellectual/developmental disabilities.AimTo explore the experiences of young adult peer‐providers with intellectual/developmental disabilities in the context of a mental health intervention.MethodsWe conducted interviews with four young adults with intellectual/developmental disabilities and their parents and teachers to understand their experiences providing a peer mentoring mental health intervention.ResultsYoung adult peer mentors perceived themselves as responsible for maintaining the mentoring relationship, delivering the intervention and acting as helpers and independent professionals. The experiences of young adult peer mentors were driven by the temporal, institutional and social contexts of their work. Peer mentoring was an enjoyable, social activity. Mentors, parents and teachers emphasised how taking on the peer mentoring role during the transition to adulthood and within the capital‐rich university context led to a sense of pride and professional development. Further, these contexts may have led mentors to emphasise their intervention‐delivery, helper and professional roles over relationship maintenance.Discussion & conclusionContext may shape the perceived roles and benefits for young adult peer mentors with intellectual/developmental disabilities.
Parental mentalising among mothers with intellectual disability or ADHD: Links with experiences of abuse, neglect and psychosocial risk
Authors: Hammarlund Mårten , Breitholtz Mia , Granqvist Pehr , Forslund Tommie 
Published: May 2023

AbstractBackgroundParental mentalising difficulties are robustly linked to caregiving problems. Mothers with intellectual disability are at risk for caregiving problems, but knowledge on their parental mentalising abilities is lacking. The present study aimed to fill this gap.MethodThirty mothers with mild intellectual disability, and 61 comparison mothers with ADHD, were assessed for parental mentalising using the Parental Reflective Functioning Questionnaire. Contributions of intellectual disability, maternal exposure to childhood abuse/neglect and psychosocial risk to parental mentalising were examined through hierarchical regression analysis.ResultsMothers with intellectual disability had a heightened risk for parental mentalising difficulties, in the form of elevated prementalising. Intellectual disability and cumulative childhood abuse/neglect uniquely predicted prementalising among the mothers, whereas cumulative psychosocial risk added to the risk for prementalising specifically among mothers with intellectual disability.ConclusionsOur findings support contextual models of caregiving, and suggest a need for mentalisation‐based support for parents with mild intellectual disability.
Studying stepfamilies, surfacing secrets: A reflection on the private motivations behind efforts to humanize family complexity
Authors: Sanner Caroline 
Published: May 2023

AbstractFeminist family scholars have long called for greater transparency of the partial perspectives embedded within family science. In this paper, I employ feminist reflexive autoethnography to unpack the private motivations that guide my research on family complexity. Using critical storytelling, I trace the personal developments that led to a research program on structurally complex families—families shaped and reshaped by divorce, separations, repartnerships, and remarriages. I explore my commitments tonaming the invisible,embracing the messy, and ultimately,humanizingthe complicated and meaningful emotions and relationships in families navigating structural changes. I draw upon personal, embodied experiences to theorize about issues and phenomena that have yet to be named in the (step)family scholarship. Finally, I invite others to heed the calls of feminist scholars whose work invites us to consider how private experiences can be leveraged to generate new insights into the complexities of family and social life.
Outcomes of robot‐assistedversuslaparoscopic surgery for colorectal cancer in morbidly obese patients: A propensity score‐matched analysis of the US Nationwide Inpatient Sample
Authors: Juang Sin‐Ei , Chung Kuan‐Chih , Cheng Kung‐Chuan , Wu Kuen‐Lin , Song Ling‐Chiao , Tang Chien‐En , Chen Hong‐Hwa , Lee Ko‐Chao 
Published: May 2023

AbstractBackground and AimMorbid obesity is associated with poorer postoperative outcomes in colorectal cancer (CRC) patients. We aimed to evaluate short‐term outcomes after roboticversusconventional laparoscopic CRC resection in morbidly obese patients.MethodsThis population‐based, retrospective study extracted data from the US Nationwide Inpatient Sample during 2005–2018. Adults ≥ 20 years old, with morbid obesity and CRC, and undergoing robotic or laparoscopic resections were identified. Propensity score matching (PSM) was applied to minimize the confounding. Univariate and multivariable regression was conducted to evaluate the associations between outcomes and study variables.ResultsAfter PSM, 1296 patients remained. The risks of any postoperative complication (adjusted odds ratio [aOR] = 0.99, 95% confidence interval [CI]: 0.80, 1.22), prolonged length of stay (LOS) (aOR = 0.80, 95% CI: 0.63, 1.01), death (aOR = 0.57, 95% CI: 0.11, 3.10), or pneumonia (aOR = 1.13, 95% CI: 0.73, 1.77) were not significantly different between the two procedures after adjustment. Robotic surgery was significantly associated with greater hospital cost (aBeta = 26.26, 95% CI: 16.08, 36.45) than laparoscopic surgery. Stratified analyses revealed that, in patients with tumor located at the colon, robotic surgery was associated with lower risk of prolonged LOS (aOR = 0.72, 95% CI: 0.54, 0.95).ConclusionsIn patients with morbid obesity, risks of postoperative complication, death, or pneumonia are not significantly different between robotic and laparoscopic CRC resection. Among patients with tumor located at the colon, robotic surgery is associated with lower risk of prolonged LOS. These findings fill the knowledge gap and provide useful information for clinicians on risk stratification and treatment choice.
Expert elicitation and data noise learning for material flow analysis using Bayesian inference
Authors: Dong Jiayuan , Liao Jiankan , Huan Xun , Cooper Daniel 
Published: May 2023

AbstractBayesian inference allows the transparent communication and systematic updating of model uncertainty as new data become available. When applied to material flow analysis (MFA), however, Bayesian inference is undermined by the difficulty of defining proper priors for the MFA parameters and quantifying the noise in the collected data. We start to address these issues by first deriving and implementing an expert elicitation procedure suitable for generating MFA parameter priors. Second, we propose to learn the data noise concurrent with the parametric uncertainty. These methods are demonstrated using a case study on the 2012 US steel flow. Eight experts are interviewed to elicit distributions on steel flow uncertainty from raw materials to intermediate goods. The experts' distributions are combined and weighted according to the expertise demonstrated in response to seeding questions. These aggregated distributions form our model parameters' informative priors. Sensible, weakly informative priors are adopted for learning the data noise. Bayesian inference is then performed to update the parametric and data noise uncertainty given MFA data collected from the United States Geological Survey and the World Steel Association. The results show a reduction in MFA parametric uncertainty when incorporating the collected data. Only a modest reduction in data noise uncertainty was observed using 2012 data; however, greater reductions were achieved when using data from multiple years in the inference. These methods generate transparent MFA and data noise uncertainties learned from data rather than pre‐assumed data noise levels, providing a more robust basis for decision‐making that affects the system.
Examining intervention hours attended for couples randomly assigned to receive relationship education
Authors: Carlson Ryan G. , Gao Ruiqin , Gordon Rainie , Go Jungsun , Taylor Dalena Dillman , Barden Sejal M. 
Published: May 2023

AbstractRelationship education (RE) has shown promise as an effective intervention for couples. Yet, challenges exist with retaining low‐income couples and federal funding required that grantees provide at least 12 h of core content. We conducted a follow‐up analysis to a randomized trial of RE with low‐income couples. We focused on couples randomly assigned to the treatment (N = 579) and examined the influence of intervention hours on emotion regulation, dyadic coping, and individual distress at 1 and 6‐month follow‐up. Results of longitudinal actor‐partner interdependence models indicated that women who completed the program reported fewer difficulties in emotion regulation at 6‐month follow‐up than women who attended fewer intervention hours. Additionally, men who completed reported more individual distress at 1‐month follow‐up than men who attended fewer hours. Given that most couples were Hispanic, we conducted an exploratory analysis to examine language as a covariate with mixed results.
Stigma, social and structural vulnerability, and mental health among transgender women: A partial least square path modeling analysis
Authors: Sherman Athena D. F. , Higgins Melinda K. , Balthazar Monique S. , Hill Miranda , Klepper Meredith , Schneider Jason S. , Adams Dee , Radix Asa , Mayer Kenneth H. , Cooney Erin E. , Poteat Tonia C. , Wirtz Andrea L. , Reisner Sari L. ,   American Cohort to Study HIV Acquisition Among Transgender Women (LITE) Study Group
Published: May 2023

AbstractIntroductionExisting literature suggests that transgender women (TW) may be at high risk for adverse mental health due to stress attributed to combined experiences of stigma and complex social and structural vulnerabilities. Little research has examined how these co‐occurring experiences relate to mental health. We aimed to test a theoretically driven conceptual model of relationships between stigma, social and structural vulnerabilities, and mental health to inform future intervention tailoring.Design/MethodsPartial least square path modeling followed by response‐based unit segmentation was used to identify homogenous clusters in a diverse community sample of United States (US)‐based TW (N = 1418; 46.2% White non‐Hispanic). This approach examined associations between latent constructs of stigma (polyvictimization and discrimination), social and structural vulnerabilities (housing and food insecurity, unemployment, sex work, social support, and substance use), and mental health (post‐traumatic stress and psychological distress).ResultsThe final conceptual model defined the structural relationship between the variables of interest within stigma, vulnerability, and mental health. Six clusters were identified within this structural framework which suggests that racism, ethnicism, and geography may be related to mental health inequities among TW.ConclusionOur findings around the impact of racism, ethnicism, and geography reflect the existing literature, which unfortunately shows us that little change has occurred in the last decade for TW of color in the Southern US; however, the strength of our evidence (related to sampling structure and sample size) and type of analyses (accounting for co‐occurring predictors of health, i.e., stigma and complex vulnerabilities, reflecting that of real‐world patients) is a novel and necessary addition to the literature. Findings suggest that health interventions designed to offset the negative effects of stigma must include anti‐racist approaches with components to reduce or eliminate barriers to resources that contribute to social and structural vulnerabilities among TW. Herein we provide detailed recommendations to guide primary, secondary, and tertiary prevention efforts.Clinical RelevanceThis study demonstrated the importance of considering stigma and complex social and structural vulnerabilities during clinical care and design of mental health interventions for transgender women who are experiencing post‐traumatic stress disorder and psychological distress. Specifically, interventions should take an anti‐racist approach and would benefit from incorporating social support‐building activities.
Model‐based estimation of the health care expenditure and out‐of‐pocket payment for assisted reproductive technology: A retrospective linkage study using the Japanese national ART registry
Authors: Jwa Seung Chik , Goto Rei , Maeda Eri , Kajihara Takeshi , Ishihara Osamu 
Published: May 2023

AbstractAimFrom April 2022, the Japanese government funding system for assisted reproductive technology (ART) has shifted from government subsidies to universal health insurance. To date, studies estimating the health care expenditure for ART are scarce. We estimated health care expenditures for ART cycles and compared the proportion of patients' out‐of‐pocket payment by ovarian stimulation protocols under the Japanese government subsidy system.MethodsWe linked payment information for government subsidies in Saitama Prefecture during 2016 and 2017 with the Japanese ART registry. Health care expenditures for all treatment cycles in Japan during 2017 among women aged <43 years (n = 369 757) were estimated using a generalized linear model.ResultsWe linked 6269 subsidy applications to the Japanese ART registry. The average treatment fee for a fresh cycle was 376 434 JPY (standard deviation = 159 581). However, significant variation was observed across ovarian stimulation protocols. The estimated health care expenditure for ART during 2017 was 101 278 629 888 JPY (920 714 817 USD), leading to a 0.24% increase in the national health care expenditure for fiscal year 2017. Fresh cycles accounted for 70% of the expenditure. The proportion of the average patient out‐of‐pocket payment for one treatment cycle was smaller for natural (0%) and mild ovarian stimulation using clomiphene citrate (4.5%–20.7%) than those of conventional stimulation (30.3%–32.4%).ConclusionsHealth insurance coverage for ART would increase national health care expenditure by 0.24%. Under the subsidy system, the proportion of the average patient out‐of‐pocket payment was smaller for natural and mild ovarian stimulation than conventional stimulations.
Comparison of functional and esthetic outcomes in digital versus analog rehabilitation of one‐piece screw‐retained implant crowns placed at second stage surgery
Authors: Edinger Dieter , Henningsen Anders , Bibiza Eric , Smeets Ralf , Joda Tim 
Published: May 2023

AbstractPurposeAnalog and digital impressions are established procedures for restoration of single‐tooth implants. In this study, single‐tooth implants were restored with definitive restorations during second‐stage surgery. Analog and digital workflows were compared.Material and MethodsEighty single‐tooth implants were examined in total. In 40 implants, an index was taken immediately after implant placement using composite resin to fabricate the final crowns (analog workflow). For the other 40 single‐tooth implants, intraoral intraoperative scans were performed (digital workflow) during primary surgery. The custom‐fabricated screw‐retained crowns were placed during second‐stage surgery. Photographs and examinations for the scores were taken at the time of the follow‐up visit, 1–4 years after placement of the crowns. The number of treatment appointments required was recorded and the modified pink esthetic score (PES) was determined. Additionally, the functional implant prosthetic score (FIPS) was measured.ResultsThe mean PES was 12.15/14 for the digital workflow and 11.95/14 for the analog workflow. The most common deficit was incomplete papillae for both workflows. Three treatment appointments were required for both workflows: (1) Scan and/or impressions making and patient consent, (2) implant placement, and (3) second‐stage surgery with crown insertion. The FIPS was 9.1/10 for the digital workflow group and 9.2/10 for the analog workflow group. Common deficits presented as missing papillae as well as open approximal contacts. The FIPS was not significantly different between workflows (p = 0.679). The PES also did not show a statistically significant difference for both workflows (p = 0.654), however, the analog workflow showed better values for the papillae (p < 0.05). A significant difference was also found in the other PES values, with the digital workflow showing better results here (p < 0.05). A chronological analysis of the results of the digital technique showed that the cases treated last had significantly better values than the cases treated first.ConclusionsAccording to the results of this study, both workflows allowed placement of the definitive crowns on single‐tooth implants during second‐stage surgery. Both workflows were found to be equivalent in terms of esthetic results in this study, although the digital workflow demonstrated a learning curve.