bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elastic Organic Crystals as Bioinspired Hair‐Like Sensors
Authors: Yousuf Soha , Mahmoud Halabi Jad , Tahir Ibrahim , Ahmed Ejaz , Rezgui Rachid , Li Liang , Laws Praveen , Daqaq Mohammed , Naumov Panče 
Published: December 2022

AbstractOne of the typical haptic elements are natural hairy structures that animals and plants rely on for feedback. Although these hair sensors are an admirable inspiration, the development of active flow sensing components having low elastic moduli and high aspect ratios remains a challenge. Here, we report a new sensing approach based on a flexible, thin and optically transmissive organic crystal of high aspect ratio, which is stamped with fluorescent dye for tracking. When subjected to gas flow and exposed to laser, the crystal bends due to exerted pressure and acts as an optical flow (hair) sensor with low detection limit (≈1.578 m s−1) and fast response time (≈2.70 s). The air‐flow‐induced crystal deformation and flow dynamics response are modelled by finite element analysis. Due to having a simple design and being lightweight and mechanically robust this prototypical crystal hair‐like sensor opens prospects for a new class of sensing devices ranging from wearable electronics to aeronautics.
Copper‐Catalyzed C(sp3)‐Amination of Ketone‐Derived Dihydroquinazolinones by Aromatization‐Driven C−C Bond Scission
Authors: Lv Xin‐Yang , Abrams Roman , Martin Ruben 
Published: December 2022

AbstractHerein, we describe the development of a copper‐catalyzed C(sp3)‐amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open‐shell species arising from homolytic C−C bond‐cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.
Tandem Mass Spectrometry Imaging Enables High Definition for Mapping Lipids in Tissues
Authors: Guo Xiangyu , Cao Wenbo , Fan Xiaomin , Guo Zhiying , Zhang Donghui , Zhang Haoyue , Ma Xiaoxiao , Dong Jiahong , Wang Yunfang , Zhang Wenpeng , Ouyang Zheng 
Published: December 2022

AbstractMass spectrometry imaging (MSI) of lipids in biological tissues is useful for correlating molecular distribution with pathological results, which could provide useful information for both biological research and disease diagnosis. It is well understood that the lipidome could not be clearly deciphered without tandem mass spectrometry analysis, but this is challenging to achieve in MSI due to the limitation in sample amount at each image spot. Here we develop a multiplexed MS2 imaging (MS2I) method that can provide MS2 images for 10 lipid species or more for each sampling spot, providing spatial structural lipidomic information. Coupling with on‐tissue photochemical derivatization, imaging of 20 phospholipid C=C location isomers is also realized, showing enhanced molecular images with high definition in structure for mouse brain and human liver cancer tissue sections. Spatially mapped t‐distributed stochastic neighbor embedding has also been adopted to visualize the tumor margin with enhancement by structural lipidomic information.
Uncovering Aging Chemistry of Perovskite Precursor Solutions and Anti‐aging Mechanism of Additives
Authors: Zhang Yanyan , Xing Zhi , Fan Baojin , Ni Zhigang , Wang Fuyi , Hu Xiaotian , Chen Yiwang 
Published: December 2022

AbstractThe aging of precursor solutions is the major stumbling block for the commercialization of perovskite solar cells (PSCs). Herein, for the first time we used the state‐of‐the‐art in situ liquid time‐of‐flight secondary ion mass spectrometry to molecularly explore the perovskite precursor solution chemistry. We identified that the methylammonium and formamidinium cations and the I− anion are the motivators of the aging chemistry. Further, we introduced two kinds of Lewis bases, triethyl phosphate (TP) and ethyl ethanesulfonate (EE), as new additives in the solution and unraveled that both of them can protect the reactive cations from aging through weak interactions. Significantly, TP is superior to EE in enhancing long‐term solution stability as it can well‐maintain the internal interaction structures within the solution phase. The PSC derived from a fresh TP‐doped solution delivered a high power conversion efficiency of 23.06 %, 92.23 % of which remained in that from a 21‐day‐old solution.
Stereochemical Editing
Authors: Tan Guangying , Glorius Frank 
Published: December 2022

AbstractStereochemical editing has recently risen to prominence, allowing the direct editing of organic molecules with stereocenter(s) to adjust their relative stereochemistry at a late‐stage. Several seminal light‐driven stereochemical editing reactions such as deracemization and epimerization have been successively developed. Recently, Wendlandt and co‐workers reported a versatile photochemical epimerization of unactivated tertiary stereogenic centers to rapidly prepare the stereoisomers that were previously challenging to access.
π‐Extended Pyrrole‐Fused Heteropine: Synthesis, Properties, and Application in Organic Field‐Effect Transistors
Authors: Wang Weifan , Hanindita Fiona , Tanaka Yusei , Ochiai Kotaro , Sato Hiroyasu , Li Yongxin , Yasuda Takuma , Ito Shingo 
Published: December 2022

AbstractSulfur‐embedded polycyclic aromatic compounds have been used as building blocks for numerous organic semiconductors over the past few decades. While the success is based on thiophene‐containing compounds, aromatic compounds that contain thiepine, a sulfur‐containing seven‐membered‐ring arene, has been less well investigated. Here we report the synthesis and properties of π‐extended pyrrole‐fused heteropine compounds such as thiepine and oxepine. A π‐extended pyrrole‐fused thiepine exhibited a “pitched π‐stacking” structure in the crystal, and exhibited a high charge carrier mobility of up to 1.0 cm2 V−1 s−1in single‐crystal field‐effect transistors.
ATR‐FTIR Spectroscopy for Early Detection of Diabetic Kidney Disease
Authors: Richardson Zack , Kincses Adele , Ekinci Elif , Perez‐Guaita David , Jandeleit‐Dahm Karin , Wood Bayden R. 
Published: December 2022

AbstractCurrent screening methods for diabetic kidney disease (DKD), characterized by albumin excretion in urine, are expensive or only identify patients in late disease stages. Hence, there is need for a cost‐effective, quick, and portable screening tool which identifies patients at DKD onset. Here we report that ultracentrifugation coupled with infrared spectroscopy and machine learning can identify and quantify low level microalbuminuria in urine samples from a cohort of diabetic patients (n=155) and controls (n=22). Independent testing of the methods indicated that classification analysis discriminated between normo‐ and micro/macroalbuminuric samples with sensitivity of >91 % and specificity of >99 %. Regression methods quantified albumin concentration in the samples with error values of 17 and 44 mg/L for normo‐ and microalbuminuric patients. Using only 700 μL of sample, this approach identifies patients at an earlier stage of disease than a urinary dipstick, whilst also yielding results cheaper and faster than the albumin to creatinine ratio.
The small brown planthopper (Laodelphax striatellus) as a vector of the rice stripe virus
Authors: Kil Eui‐Joon , Kim Donghun 
Published: December 2022

AbstractThe small brown planthopper, Laodelphax striatellus, is a destructive pest insect found in rice fields. L. striatellus not only directly feeds on the phloem sap of rice but also transmits various viruses, such as rice stripe virus (RSV) and rice black‐streaked dwarf virus, resulting in serious loss of rice production. RSV is a rice‐infecting virus that is found mainly in Korea, China, and Japan. To develop novel strategies to control L. striatellus and L. striatellus‐transmitted viruses, various studies have been conducted, based on vector biology, interactions between vectors and pathogens, and omics, including transcriptomics, proteomics, and metabolomics. In this review, we discuss the roles of saliva proteins during phloem sap‐sucking and virus transmission, the diversity and role of the microbial community in L. striatellus, the profile and molecular mechanisms of insecticide resistance, classification of L. striatellus‐transmitted RSV, its host range and symptoms, its genome composition and roles of virus‐derived proteins, its distribution, interactions with L. striatellus, and resistance and control, to suggest future directions for integrated pest management to control L. striatellus and L. striatellus‐transmitted viruses.
Current understandings of olfactory molecular events in the Asian corn borer, Ostrinia furnacalis (Lepidoptera: Crambidae)
Authors: Li Jia , Zhang Long 
Published: December 2022

AbstractThe Asian corn borer Ostrinia furnacalis (Lepidoptera: Crambidae) is a serious corn pest with widespread distribution in East Asia. Its olfactory mechanism is a focus of scientific study, aiming to find good ways to control this pest. Molecular events are considered to be important in olfactory mechanism. Current understandings of olfactory molecular events in O. furnacalis, mainly involving sex pheromones and olfactory proteins, were summarized to provide a reference for further studies. O. furnacalis sex pheromone contains two components E‐12‐tetradecenyl acetate and Z‐12‐tetradecenyl acetate, which may be recognized and bound by the pheromone binding proteins OfurPBP3 and OfurPBP2, and then transported to the odorant receptors (ORs) OfurOR4 and OfurOR6 to activate them. The ORs OfurOR8, OfurOR7 and OfurOR5b mainly respond to the sex pheromone components of other Ostrinia species, E‐11‐tetradecenyl acetate, Z‐11‐tetradecenyl acetate and Z‐9‐tetradecenyl acetate. The OR OfurOR27 responds strongly to plant odorants nonanal, octanal and 1‐octanol. Much work remains to be done to fully understand odorants with olfactory activity to O. furnacalis and the functions of its olfactory proteins. These studies will help to reveal olfactory mechanism in O. furnacalis, with the aim of regulating its behaviors to control this pest.
Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4‐hydroxy‐3,5‐dimethoxy benzaldehyde motif
Authors: Demir Yeliz , Türkeş Cüneyt , Çavuş Muhammet S. , Erdoğan Musa , Muğlu Halit , Yakan Hasan , Beydemir Şükrü 
Published: December 2022

AbstractNew Schiff base‐bearing thiosemicarbazones (1–13) were obtained from 4‐hydroxy‐3,5‐dimethoxy benzaldehyde and various isocyanates. The structures of the synthesized molecules were elucidated in detail. Density functional theory calculations were also performed to determine the spectroscopic properties of the compounds. Moreover, the enzyme inhibition activities of these compounds were investigated. They showed highly potent inhibition effects on acetylcholinesterase (AChE) and human carbonic anhydrases (hCAs) (KI values are in the range of 51.11 ± 6.01 to 278.10 ± 40.55 nM, 60.32 ± 9.78 to 300.00 ± 77.41 nM, and 64.21 ± 9.99 to 307.70 ± 61.35 nM for AChE, hCA I, and hCA II, respectively). In addition, molecular docking studies were performed, confirmed by binding affinities studies of the most potent derivatives.
Enzymatic production of wax esters by esterification using lipase immobilized via physical adsorption on functionalized rice husk silica as biocatalyst
Authors: Machado Natália B. , Sabi Guilherme J. , Hirata Daniela B. , Mendes Adriano A. 
Published: December 2022

AbstractThe present study consists of developing an enzymatic process for the production of wax esters (lauryl stearate and cetyl stearate) by esterification in a heptane medium. Lipase from Thermomyces lanuginosus (TLL) immobilized via interfacial activation on silica particles from rice husks functionalized with triethoxy(octyl)silane (TLL–Octyl–SiO2) was used as biocatalyst. Maximum immobilized protein loading of around 22 mg g−1 (that corresponds to an immobilization yield of ≈55%) of support was observed using an initial protein loading of 40 mg g−1 of Octyl–SiO2. Its hydrolytic activity (olive oil emulsion hydrolysis) was of 620 U g−1 of biocatalyst. The effect of certain factors on the cetyl estearate production was evaluated using a central composite rotatable design (CCDR). Under optimal conditions (64°C, 21% of mass of biocatalyst per volume of reaction mixture, 170 rpm, and stoichiometric acid:alcohol molar ratio 1 mol L−1 of each reactant), maximum acid conversion percentage of 91% was observed after 60 min of reaction. Lauryl stearate was also produced under such conditions, and an acid conversion of 93% after 60 min of reaction was also achieved. Free lipase exhibited acid conversion of only 15%–20% for both reaction mixtures. After nine successive esterification batches, TLL–Octyl–SiO2 retained 85%–90% of its original activity. These results show the promising use of the prepared biocatalyst in wax esters production due to its high catalytic activity and reusability.
Insights in Utilizing NiCo2O4/Co3O4 Nanowires as Anode Material in Lithium‐Ion Batteries
Authors: Tomar Anubha , Adhitama Egy , Winter Martin , Placke Tobias , Rai Alok Kumar 
Published: December 2022

AbstractIn this study, a facile and cost‐effective hydrothermal approach is employed to synthesize a mesoporous NiCo2O4/Co3O4 nanocomposite with nanowire morphology by using polyvinyl pyrrolidone as structure‐directing agent. The obtained NiCo2O4/Co3O4 nanocomposite shows better electrochemical performance than pure NiCo2O4 due to mainly two reasons: i) a strong synergistic effect between NiCo2O4 and Co3O4, which enhances the Li+ diffusion rate as well as lower the charge‐transfer resistance, and ii) the involvement of Co3O4 to contribute to the total capacity due to its high electrochemical activity. However, the performance of a NiCo2O4/Co3O4 nanocomposite electrode starts degrading after 400 cycles while pure NiCo2O4 maintains steady performance. Since the NiCo2O4/Co3O4 nanocomposite sample shows high porosity, it is believed that the obtained nanowire morphology cannot tolerate volume variations, which are generally triggered off during repeated Li+ (de‐)insertion at long‐term cycling. Therefore, the obtained results bring new insights in terms that there is a sweet spot between Li+ diffusion and high porosity in utilizing Co3O4 within a nanocomposite. This study is of guidance to shed the light on the research of ternary transition metal oxide nanocomposite materials for lithium‐ion batteries.
Socioeconomic disparities in sleep duration are associated with cortical thickness in children
Authors: Hansen Melissa , Simon Katrina R. , Strack Jordan , He Xiaofu , Noble Kimberly G. , Merz Emily C. 
Published: December 2022

AbstractIntroductionDisrupted sleep has been consistently linked with lower academic achievement and worse mental health in children. Less is understood about sleep as a potential factor underlying socioeconomic differences in brain morphometry in children. The goals of this study were to investigate the associations among socioeconomic factors, sleep duration, and brain morphometry in children, and to examine the roles of the sleep environment and family routines in these associations.MethodsParticipants were 5‐ to 9‐year‐old children from socioeconomically diverse families (N = 94; 61% female). Parents reported on children's weekday and weekend sleep durations, sleep environment, and family routines. High‐resolution, T1‐weighted structural magnetic resonance imaging (MRI) data were acquired. Analyses focused on cortical thickness, cortical surface area, and amygdala and hippocampal volume.ResultsResults indicated that lower family income‐to‐needs ratio and parental education were significantly associated with shorter weekday sleep duration in children. Shorter weekday sleep duration was significantly associated with reduced thickness in the left middle temporal, right postcentral, and right superior frontal cortices and smaller basolateral but not centromedial amygdala volume. Family routines significantly mediated the associations of family income‐to‐needs ratio and parental education with weekday sleep duration in children.ConclusionThese results contribute to our understanding of sleep factors as proximal mechanisms through which socioeconomic context may alter neural development during childhood.
Blood supply to the superficial fascia of the abdomen: An anatomical study
Authors: Pirri Carmelo , Petrelli Lucia , Fede Caterina , Guidolin Diego , Tiengo Cesare , De Caro Raffaele , Stecco Carla 
Published: December 2022

AbstractThe aim of this study was to examine data demonstrating that Scarpa's fascia, a superficial fascia of the anterior abdominal wall, is a vascularized tissue. Specimens of the fascia of seven volunteers undergoing abdominoplasty surgical procedures at the Plastic Surgery Unit of the University of Padova Medical Center were collected. Fractal analysis and quantitative assessment of the vascular network of the fascia was carried out, exploiting the presence of blood in the vessels. Each sample was divided and processed for histological/immunohistochemical analysis (into 5 micron‐paraffin embedded sections and cryo‐sectioned free‐floating samples) as well as for electron microscopy study. A rich vascular pattern forming a fine, dense meshwork with an area percentage of 6.20% ± 2.10% von Willebrand factor stained vessels was noted in all the specimens of the fascia examined; the area percentage of the αSMA‐stained vessels was 2.93% ± 1.80%. The diameters of the vessels fell between the 13 and 65 μm range; the network was composed of arteries, veins, capillaries and lymphatic segments. Topological results showed that the vascular network within Scarpa's fascia is well branched (segments: 6615 ± 3070 and 8.40 ± 3.40 per mm2; crossing points: 3092 ± 1490 and 3.40 ± 1.90 per mm2). Fractal analysis (fractal dimension = 1.063 ± 0.10; lacunarity = 0.60 ± 0.10) revealed that this particular vascular network has an optimal spatial distribution and homogeneity occupying the entire space of the superficial fascia. These findings could undoubtedly be useful to plastic surgeons as well as to pain management specialists.
The TSPCAN project: A qualitative evaluation with undergraduate students trained in child abuse prevention in Turkey
Authors: Dolunayğ‐Cuğ Fevziye , Yılmaz‐Akdoğan Gökçe , Derman Orhan , Şahin Özge , Dağlı Şahin Figen , Paslı Figen , Güngör Emre , Gökler Bahar 
Published: December 2022

AbstractOrganising primary prevention programs for child abuse and neglect is among the key responsibilities of the Turkish Society for Prevention of Child Abuse and Neglect (TSPCAN). TSPCAN conducted a project which provided university students who in the future may encounter individuals with child abuse experiences with guidance with regards to a child abuse prevention program. The aim of this study was to qualitatively evaluate the influences of TSPCAN's project on young professionals who were the facilitators of this program as undergraduate students in medical, health and social science degrees. Twenty participants were recruited through a purposeful and convenient sampling method. The data were first collected with a structured questionnaire. Then, two focus groups were conducted with nine (45%) of these participants. Thematic analysis was utilised for both data collection waves. Findings were organised under three themes: (i) aims for participation in the project; (ii) acquired awareness in the project; and (iii) contributions of the project in their professional lives. Findings highlight the importance of including university students in child abuse prevention programs to provide the knowledge and awareness they need as future professionals.
Factors limiting the application of consumer neuroscience: A systematic review
Authors: Kansra Pooja , Oberoi Sumit , Gupta Shankar Lal , Singh Nripendra 
Published: December 2022

AbstractNeuromarketing is perceived as burgeoning innovation in marketing research which facilitates understanding consumer behaviour and decision‐making. Given this potential, still, most enterprises resist implementing neuromarketing techniques. Therefore, this study aims to identify the determinants that limits the application of neuromarketing. An extensive literature review was performed on databases such as Emerald, Jstor, Sage, Scopus and Web of Science. The inclusion criteria are grounded upon the ‘Population Intervention Comparison Outcome Study’ procedure and articles restricted to the English language, published between 2007 and July 2022 and indexed under peer‐reviewed journals. A total of 36 research articles are included and not even a single study was obtained from Mediterranean & Middle East. Sixteen key determinants were acknowledged under the subcategory of psychological and operational variables as presented in the conceptual framework. These identified variables trigger psychological and operation constraints in decision making, thereby limiting the application of neuromarketing decisions. This study directs the need for a general level of cognizance and acknowledgment about neuromarketing, further developing the innovation culture in business corporates and affiliate marketing research needs to neuromarketing techniques.
MicroRNA miR‐125b can suppress ovarian granulosa cell functions: Interrelationships with FSH
Authors: Fabová Zuzana , Loncová Barbora , Sirotkin Alexander V. 
Published: December 2022

AbstractThis study aimed to evaluate the involvement of miR‐125b and its interrelationship with follicle‐stimulating hormone (FSH) in the control of basic ovarian granulosa cell functions. The effect of miR‐125b mimics on basic functions of porcine ovarian granulosa cells cultured with and without FSH, and the effect of FSH on the expression of endogenous miR‐125b was examined. Expression levels of miR‐125b, viability, proliferation (accumulation of PCNA and cyclin B1), apoptosis (accumulation of bax and caspase 3), the accumulation of FSH receptors (FSHR), steroid hormones, insulin‐like growth factor I (IGF‐I), oxytocin, and prostaglandin E2 release were analysed by reverse transcription‐quantitative polymerase chain reaction, Trypan blue exclusion test, quantitative immunocytochemistry, and ELISA. Transfection of cells with miR‐125b mimics inhibited cell viability, proliferation, apoptosis, the occurrence of FSHR, progesterone, testosterone, estradiol, and oxytocin release but stimulated prostaglandin E2 output. FSH promoted cell viability, proliferation, steroid hormones, IGF‐I, oxytocin, and prostaglandin E2 output and reduced the expression of miR‐125b and apoptosis. Furthermore, miR‐125b mimics supported the effect of FSH on the release of estradiol, IGF‐I, and prostaglandin E2, and inverted FSH influence on cell viability, proliferation, apoptosis, progesterone, and testosterone output. FSH supported both inhibitory and stimulatory action of miR‐125b on ovarian cell functions. Present observations indicate that: miR‐125b can be involved in the control of basic ovarian functions and that miR‐125b and FSH are antagonists in their actions on ovarian cell functions. The ability of FSH to reduce miR‐125b expression and the ability of miR‐125b mimics to decrease the occurrence of FSHR and to modify FSH effects indicate the existence of the self‐inhibiting FSH‐miR‐125b axis and that miR‐125b can mediate the actions of FSH on ovarian cells.
Lead poisoning with unusual manifestations in an opium‐addicted man
Authors: Abedi Samakoosh Mohammad , Sharifpour Ali , Soleymani Mostafa , Zakariaei Zakaria 
Published: December 2022

AbstractOne of the contributing causes of hypertension or exacerbation of ischemic heart disease (IHD) has been suggested to be environmental pollution and occupational exposure to particular metals, such as lead. Here, we describe a 43‐year‐old man with a history of oral opium with symptoms of IHD due to chest pain.