bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomic tumor phenotypes augment molecular profiling in predicting recurrence free survival after breast neoadjuvant chemotherapy
Authors: Chitalia Rhea , Miliotis Marios , Jahani Nariman , Tastsoglou Spyros , McDonald Elizabeth S. , Belenky Vivian , Cohen Eric A. , Newitt David , van’t Veer Laura J. , Esserman Laura , Hylton Nola , DeMichele Angela , Hatzigeorgiou Artemis , Kontos Despina 
Published: April 2023

Abstract
Background
Early changes in breast intratumor heterogeneity during neoadjuvant chemotherapy may reflect the tumor’s ability to adapt and evade treatment. We investigated the combination of precision medicine predictors of genomic and MRI data towards improved prediction of recurrence free survival (RFS).

Methods
A total of 100 women from the ACRIN 6657/I-SPY 1 trial were retrospectively analyzed. We estimated MammaPrint, PAM50 ROR-S, and p53 mutation scores from publicly available gene expression data and generated four, voxel-wise 3-D radiomic kinetic maps from DCE-MR images at both pre- and early-treatment time points. Within the primary lesion from each kinetic map, features of change in radiomic heterogeneity were summarized into 6 principal components.

Results
We identify two imaging phenotypes of change in intratumor heterogeneity (p < 0.01) demonstrating significant Kaplan-Meier curve separation (p < 0.001). Adding phenotypes to established prognostic factors, functional tumor volume (FTV), MammaPrint, PAM50, and p53 scores in a Cox regression model improves the concordance statistic for predicting RFS from 0.73 to 0.79 (p = 0.002).

Conclusions
These results demonstrate an important step in combining personalized molecular signatures and longitudinal imaging data towards improved prognosis.
Fluorescent 7-azaindoleN-linked 1,2,3-triazole: synthesis and study of antimicrobial, molecular docking, ADME and DFT properties
Authors: Sharma Kanika , Tittal Ram Kumar , Lal Kashmiri , Mathpati Ramling S. , D. Ghule Vikas 
Published: April 2023

Two libraries of antimicrobial and fluorescent 7-azaindole N-linked benzyl/phenyl 1,2,3-triazole hybrids have been synthesized via Cu (II) catalyzed click reaction. Molecular docking, ADME, Molinspiration and DFT studies were also carried out.
Analytical modelling of high‐frequency losses in toroidal inductors
Authors: Zhao Yuhu , Ming Zhengfeng , Han Binbin 
Published: April 2023

AbstractToroidal inductors are widely used in power electronic systems. With the increasing switching frequency of power devices, the AC losses of high‐frequency inductor windings have become an issue that cannot be ignored in design. A method with low computational time cost and high accuracy is urgently needed by designers. This paper proposes a modified analytical method for winding loss calculation of toroidal inductors based on the one‐dimensional Dowell method and the two‐dimensional Ferreira method, and proposes a compensated analytical model considering the proximity effect of inter‐turn conductors of toroidal windings. The analytical method calculates the non‐linear porosity of toroidal windings, and can accurately solve the AC losses of toroidal inductors with arbitrary porosity winding encapsulation. The analytical results are in good agreement with the finite element method (FEM) and experimental data. The experimental measurement data verifies the validity of the proposed model within 1‐MHz frequency, the calculation error of the modified analytical method is less than 25%, and the calculation error of the compensated analytical model is reduced to 10%.
Search for lithium-rich giants in 32 open clusters with high-resolution spectroscopy
Authors: Tsantaki M. , Delgado-Mena E. , Bossini D. , Sousa S. G. , Pancino E. , Martins J. H. C. 
Published: April 2023

Context.Lithium-rich giant stars are rare and their existence poses a challenge to our understanding of stellar structure and evolution. In particular, open clusters aptly constrain the mass and age of their members, offering a unique opportunity to understand the evolutionary stage where Li enrichment occurs.Aims.We take advantage of the high-quality sample gathered for the search for planets in open clusters with HARPS and UVES to look for Li-rich giants and to identify the Li enrichment mechanisms responsible.Methods.We derived stellar parameters for 247 stars belonging to 32 open clusters, with 0.07 Ga < ages < 3.6 Ga. We employed the spectral synthesis technique code FASMA for the abundance analysis of 228 stars from our sample. We also determined the ages, distances, and extinction using astrometry and photometry fromGaiaand PARSEC isochrones to constrain their evolutionary stage. Our sample covers a wide range of stellar masses from 1 to more than 6M⊙where the majority of the masses are above 2M⊙.Results.We find 14 canonical Li-rich giant stars that have experienced the first dredge-up. This corresponds to 6% of our total sample, higher than what is typically found for field stars. The majority of the stars (11/14) are located at the red clump, two lie on the red giant branch, and we could not conclude on its evolutionary stage for one. Apart from the canonical limit, we used the maximum Li abundance of the progenitor stars as a criterion for Li enrichment and found 12 Li enriched stars (five appearing in the red clump, five at the upper red giant branch, and two that are inconclusive). We find Li enhancement also among eight stars that have passed the first dredge-up and show strong Li lines based on the fact that stars at the same evolutionary stage in the same cluster have significantly different Li abundances. We confirm that giants with higher Li abundances correspond to a higher fraction of fast-rotating giants, suggesting a connection between Li enhancement and stellar rotation, as predicted by stellar models.Conclusions.Our Li-rich giants are found in various evolutionary stages, implying that no unique Li production mechanism is responsible for Li enrichment. Instead, there are different intrinsic or external mechanisms that are simultaneously at play.
New constraints on the presence of debris disks around G 196-3 B and VHS J125601.92–125723.9 b
Authors: Zakhozhay Olga V. , Osorio María Rosa Zapatero , Béjar Víctor J. S. , Climent Juan Bautista , Guirado José Carlos , Gauza Bartosz , Lodieu Nicolas , Semenov Dmitry A. , Perez-Torres Miguel , Azulay Rebecca , Rebolo Rafael , Martín-Pintado Jesús , Lefèvre Charlène 
Published: April 2023

Context. The existence of warm (protoplanetary) disks around very young isolated planetary and brown dwarf mass objects is known based on near- and mid-infrared flux excesses and millimeter observations. These disks may later evolve into debris disks or rings, although none have been observed or confirmed so far. Little is known about circum(sub)stellar and debris disks around substellar objects.
Aims. We aim to investigate the presence of debris disks around two of the closest (~20 pc), young substellar companions, namely G196-3 B and VHS J125601.92–125723.9 b (VHS J1256–1257 b), whose masses straddle the borderline between planets and brown dwarfs. Both are companions at wide orbits (≥100 au) of M-type dwarfs and their ages (50–100 Myr and 150–300 Myr, respectively) are thought to be adequate for the detection of second-generation disks.
Methods. We obtained deep images of G196-3 B and VHS J1256–1257 b with the NOrthern Extended Millimeter Array (NOEMA) at 1.3 mm. These data were combined with recently published Atacama Large Millimeter Array (ALMA) and Very Large Array (VLA) data of VHS J1256–1257 b at 0.87 mm and 0.9 cm, respectively.
Results. Neither G196-3 B nor VHS J1256–1257 b were detected in the NOEMA, ALMA, and VLA data. At 1.3 mm, we imposed flux upper limits of 0.108 mJy (G196-3 B) and 0.153 mJy (VHS J1256–1257 b) with a 3-σ confidence. Using the flux upper limits at the millimeter and radio wavelength regimes, we derived maximum values of 1.38×10−2 MEarth and 5.46 × 10−3 MEarth for the mass of any cold dust that might be surrounding G196-3 B and VHS J1256–1257 b, respectively.
Conclusions. We put our results in the context of other deep millimeter observations of free-floating and companion objects with substellar masses smaller than 20 MJup and ages between approximately one and a few hundred million years. Only two very young (2–5.4 Myr) objects are detected out of a few tens of them. This implies that the disks around these very low-mass objects must have small masses, and possibly reduced sizes, in agreement with findings by other groups. If debris disks around substellar objects scale down (in mass and size) in a similar manner as protoplanetary disks do, millimeter observations of moderately young brown dwarfs and planets must be at least two orders of magnitude deeper to be able to detect and characterize their surrounding debris disks.
Relevanz der Laser-Flare-Photometrie bei retinalen Pathologien
Authors: Schöneberger Verena , Menghesha Leonie , Feltgen Nicolas , Fuchsluger Thomas Armin , Cursiefen Claus , Schaub Friederike 
Published: April 2023

ZusammenfassungMithilfe der Laser-Flare-Photometrie kann eine nicht invasive und objektive Messung des Tyndall-Effekts in der Vorderkammer erfolgen. Der Laser-Flare-Wert (Tyndallometrie; gemessen in
Photonenzahl pro Millisekunde [pc/ms]) quantifiziert somit das Ausmaß einer Störung der Blut-Kammerwasser-Schranke und kann dadurch in der klinischen Anwendung zur Überwachung einer
Uveitistherapie oder zum Messen eines postoperativen Entzündungsgrades verwendet werden. Bei der Messung ist eine standardisierte Durchführung zu beachten. Publikationen der letzten 35 Jahre
zur Laser-Flare-Photometrie beschäftigen sich neben dem Messverfahren mit dessen Einsatz in der klinischen Praxis bei unterschiedlichen ophthalmologischen Erkrankungen. Ebenso wurden bereits
verschiedene Einflussfaktoren untersucht und beschrieben, die bei der Messung und Auswertung von Laser-Flare-Werten zu beachten sind. Fokus dieses Beitrags ist die Relevanz der
Laser-Flare-Photometrie in der Retinologie. In kürzlich veröffentlichten Studien zeigt sich die Höhe der objektiven Tyndallometrie bei einer primären rhegmatogenen Amotio abhängig vom
Linsenstatus, der Symptomdauer und dem Ausmaß der Netzhautablösung. Je mehr Fläche der Netzhaut betroffen ist, desto größer scheint die Störung der Blut-Kammerwasser-Schranke. Erhöhte
Laser-Flare-Werte galten zudem bislang als Prädiktor für die Entwicklung einer proliferativen Vitreoretinopathie (PVR), jedoch muss diese Annahme nach aktuellem Kenntnisstand relativiert
werden. Die objektive Tyndallometrie kann nach derzeitiger Datenlage zur Verlaufskontrolle bei intraokularen Entzündungen und zur Quantifizierung der Blut-Kammerwasser-Schranke genutzt
werden. Die Werte korrelieren mit dem Ausmaß und anatomischen Gegebenheiten sowie der Symptomdauer bei Netzhautablösung. Es gibt viele bereits identifizierte Einflussfaktoren, eine weitere
Evaluation ist jedoch wünschenswert und erforderlich. Ob der Laser-Flare-Wert zukünftig als Prädiktor für Folgeerkrankungen wie bspw. die PVR-Entwicklung genutzt werden kann, ist derzeit
noch unklar.
Forschungsdatenzentrum Gesundheit – Vision für eine
Weiterentwicklung aus Sicht der Forschung
Authors: March Stefanie , Hoffmann Falk , Andrich Silke , Gothe Holger , Icks Andrea , Meyer Ingo , Nimptsch Ulrike , Scholten Nadine , Schulz Mandy , Semler Sebastian Claudius , Stallmann Christoph , Swart Enno , Ihle Peter 
Published: April 2023

ZusammenfassungDas Forschungsdatenzentrum (FDZ) Gesundheit nach der Datentransparenzverordnung
(DaTraV), angesiedelt am Bundesinstitut für Arzneimittel und
Medizinprodukte (BfArM) wird Routinedaten der Gesetzlichen Krankenversicherung
für die Forschung bereitstellen. Die Bereitstellung der Daten von knapp
90% der Bevölkerung in Deutschland dient dem
übergeordneten Ziel, die gesundheitliche Versorgung im Hinblick auf
Unter-, Über- und Fehlversorgung zu evaluieren und daraus
Handlungsempfehlungen für eine evidenzbasierte Gesundheitsversorgung
abzuleiten. Der gesetzliche Rahmen wird im Sozialgesetzbuch (§§
303a-f SBG V) und zwei dazu gehörigen Verordnungen gesteckt,
lässt jedoch hinreichend großen Spielraum für die
Ausgestaltung auf der Organisations- und Arbeitsebene. Hier setzt das
vorliegende Papier an. Aus Forscher*innensicht wurden zehn Statements
für eine Weiterentwicklung formuliert, die das Potential eines
Forschungsdatenzentrums aufzeigen und Ideen für die weitere
zukunftsfähige Ausgestaltung und Entwicklung mit Bestandskraft
darlegen.
Pre-hospital and Hospital Trauma Care during the Covid-19 Lockdown – Experience in a Metropolitan European Level 1 Trauma Centre
Authors: Scherer Julian , Canal Claudio , Kaufmann Ernest , Jensen Kai Oliver , Pape Hans-Christoph , Neuhaus Valentin 
Published: April 2023

Abstract
Background Trauma case load is said to have declined during the Covid-19 pandemic, especially during the national lockdowns. Due to the altered frequency and changes in daily life, pre-hospital care (altered personal protective measurements) as well as mechanisms of trauma and initial trauma treatment may have changed. The purpose of this study was to assess differences in pre-hospital as well as initial treatment of trauma victims and trauma mechanisms during a national lockdown compared to the year before.
Material and Methods Pre-hospital as well as clinical data from all trauma patients admitted to our metropolitan level 1 trauma center resuscitation room during the hard lockdown in Switzerland (March 17 to April 26, 2020) and the same time period in 2019 were analyzed retrospectively.
Results In total, we assessed 91 patients (51 lockdown cohort, 40 control cohort) with a mean age of 50.7 years. Significantly more trauma was sustained in the household environment during the lockdown (p = 0.015). Pre-hospital treatment remained similar between the two assessed groups. No difference was found in length of stay or mortality. In severely injured patients (ISS > 15), we found significantly fewer motor vehicle accidents (p = 0.018) and fewer horizontal decelerations (p = 0.006), but insignificantly more falls (p = 0.092) in the lockdown cohort. None of the patients in the lockdown cohort had a positive PCR test for Covid-19 on admission.
Conclusion Trauma systems seem not to have changed during hard lockdowns in terms of pre-hospital treatment. Fewer severely injured patients due to motor vehicle accidents and horizontal decelerations, but more household-related injuries were seen in the lockdown cohort than in the control cohort. A qualitative analysis of treatment during the hard lockdown is needed to gain further insights into the effect of the pandemic on trauma care.
Bio-evaluation of Untapped Alkaloids from Vinca minor Enriched by Methyl-jasmonate-induced Stress: an Integrated Approach
Authors: El-Senduny Fardous F. , Elgazar Abdullah A. , Alwasify Heba Allah , Abed Alaa , Foda Mohamed , Abouzeid Sara , Lewerenz Laura , Selmar Dirk , Badria Farid 
Published: April 2023

AbstractThe low amount of metabolites isolated from natural products is one of the challenges preventing their biological evaluation. The modulation of biosynthetic pathways by stimulating
stress-induced responses in plants was proven to be a valuable tool for diversification of already known natural products. Recently, we reported the dramatic effect of methyl jasmonate
(MeJA) on Vinca minor alkaloids distribution. In this study, three compounds identified as 9-methoxyvincamine, minovincinine, and minovincine are successfully isolated in good yield
and subjected to several bioassays based on a network pharmacology study. The extracts and isolated compounds show weak to moderate antimicrobial and cytotoxic activities. Also, they are
found to significantly promote wound healing in scratch assay, and transforming growth factor-β (TGF-β) modulation is suggested to be the potential pathway based on
bioinformatic analysis. Hence, Western blotting is used to assess the expression of several markers related to this pathway and wound healing. The extracts and isolated compounds are able to
increase the expression of Smad3 and Phosphatidylinositol-3-kinase (PI3K), while downregulating the levels of cyclin D1 and the mammalian target of rapamycin (mTOR) except for minovincine,
which increases the mTOR expression, inferring that it might act through a different mechanism. Molecular docking is used to give insights on the ability of isolated compounds to bind with
different active sites in mTOR. Collectively, the integrated phytochemical, in silico, and molecular biology approach reveal that V. minor and its metabolite could be
repurposed for the management of dermatological disorders where these markers are dysregulated, which opens the gate to develop new therapeutics in the future.
Boronic Acids and Their Derivatives as Continuous-Flow-Friendly Alkyl Radical Precursors
Authors: Sharma Upendra Kumar , Oliva Monica , Chernobrovkina Viktoriia V. , Van der Eycken Erik V. 
Published: April 2023

AbstractSince its recognition as an enabling tool to form challenging C–C and C–heteroatom bonds under mild and sustainable conditions, photoredox catalysis has been in the spotlight within the synthetic community. As a consequence, the interest in developing novel synthetic strategies has spiked together with the need to define suitable technologies to overcome scale-up issues dictated by the Bouguer–Beer–Lambert law. In this context, continuous-flow reactors play a major role in increasing the efficiency of a given photocatalyzed reaction, thus rendering scale-up processes more accessible. In the alkyl radical precursor landscape, boron-based species have begun to play a predominant role. Though the reactivity of trifluoroborates has been deeply investigated, the interest in using other boron species as radical precursors in photocatalyzed reactions has recently arisen. This late exploration lies in the fact that the high oxidation potential of boronic acids (BAs) hinders their possible applications. Nevertheless, to circumvent this issue, a diverse array of activation modes has been developed, exploiting in most cases the inherent Lewis acidity of the boronic acid. The aim of this Account is to highlight our recent contribution to this vibrant field with a focus on broad applicability, selectivity, and scalability via continuous-flow methodology. For the sake of clarity, the Account is discussed under the following sections.1	Introduction2	Why Photochemistry in Flow?2.1	Preliminary Considerations2.2	Batch vs. Flow Photochemical Reactions2.3	Commercially Available Lab-Scale Solutions for Photoflow Chemistry3	Organoboron Compounds3.1	The Evolution of Organoboron Compounds as Radical Precursors in Photoredox Catalysis3.2	Organoboron Compounds in Flow4	Activation of Boronic Acids towards Radical Formation4.1	Giese-Type Addition4.2	Petasis Reaction4.3	Light-Driven Four-Component Reaction4.4	Minisci Reaction5	Conclusion and Future Perspective
Prospective Comparative Short-Term Study of Autologous Leucocyte-Rich Platelet-Rich Plasma vs. Local Steroids in Chronic Plantar Fascitis
Authors: Sakharkar Nilesh Shravan , Tathe Pankaj Vijay , Jain Prateek , Adewar Aniket N. , Pol Santosh 
Published: April 2023

Objectives
Plantar fasciitis is the most common cause of heel pain and is difficult to treat in most chronic and severe forms. Management of plantar fasciitis includes non-surgical options such as non-steroidal anti-inflammatory drugs and corticosteroids, physical therapy, orthotics, and surgical management includes plantar fasciotomy. Local injection of platelet-rich plasma as well as local steroids is an emerging concept in treating recalcitrant tendon and ligament pathology, including plantar fasciitis.
The aim of the study was to evaluate and compare the outcome of patients treated with a single injection of autologous leucocyte-rich platelet-rich plasma with single-injection local steroids triamcinolone in chronic plantar fasciitis.

Material and Methods
The study was conducted for a duration of 24 months. In total, 60 patients with clinically diagnosed chronic plantar fasciitis were selected for study and divided in two groups using the single allocation randomization method as those treated with autologous injection leucocyte-rich platelet-rich plasma and those with injection local steroid triamcinolone and prospectively followed and compared.

Results
Both groups were evaluated subjectively and functionally at primary visit and then on follow-up at 2 weeks, 4 weeks, 8 weeks, and 12 weeks by VAS and hind foot AOFAS score.

Conclusion
We concluded that both injection platelet-rich plasma-treated and injection local steroid-treated patients provide symptomatic relief in the treatment of chronic plantar fasciitis both subjectively and functionally. The steroid treated group showed early symptomatic improvement at 2 weeks, and results at 12 weeks to further follow-up were suggestive that single-injection leucocyte-rich platelet-rich plasma provided better functional results.
Antimicrobial Prescription Pattern in ENT Outpatient Department in a Tertiary Care Teaching Hospital, Telangana, India
Authors: Aalasyam Naveen , Potnuru Shilpa , Sileveru Chandra Mouli , Pokala Uma , P. Naveen 
Published: April 2023

Objectives
Otorhinolaryngological infections are very common in adults and in children also. These infections are caused by various microorganisms and to treat these infections, antimicrobial agents are used frequently. As irrational use of antimicrobials leads to the development of antibiotic resistance and it is a big threat to the society, the present study was planned to get awareness among the practitioners regarding the antimicrobial prescription pattern.
To study the prescription pattern of antimicrobial agents in outpatient department of otorhinolaryngology in a tertiary care teaching hospital.

Material and Methods
An observational study was planned over a period of 8 months from July 2019 to February 2020 in ENT outpatient department (OPD) at Mamata General Hospital, Khammam in Telangana. In total, 562 prescriptions were collected. Patient's details, probable diagnosis, prescribed medication details such as generic name, dose, and dosage forms were taken. The collected data was analyzed and the conclusions were drawn using descriptive analysis.

Results
Total number of prescriptions were 562. The majority of the prescriptions belonged to the 21 to 40 years of age group. Males were included more than females (males 320 and females 242). Chronic suppurative otitis media (CSOM) (16.2%) was the commonest infection. Most commonly prescribed antimicrobial was amoxicillin and clavulanic acid combination (26.17%), followed by cefpodoxime with clavulanic acid (21.9%) and ciprofloxacin (19.06%). In 371 (66.01%) prescriptions, only one antimicrobial was prescribed, whereas in 36 (6.40%) prescriptions no antibiotic was given. The average number of drugs per prescription was 3.18 and the average number of antimicrobials per prescription was 1.25. Tablet form (52.9%) was the commonest dosage form and most of the drugs were prescribed by generic name (74.06%).

Conclusion
The present study though prescription pattern of antibiotics and adherence to the hospital formulary by the physicians in the hospital is encouraging, still there is a chance in reducing the number of drugs prescribed per patient. The findings of this study will be useful to prescribe antimicrobials rationally so that the patient and health care system on the whole will be benefited.