bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Tourism Technology Dan Kepuasan Wisatawan Untuk Berkunjung Kembali Di Wisata Heritage Kota Surakarta
Authors: Rahmawati Esti Dwi , Admadianto Haris Novy , Fadila Sarah , Baaq Shalli Habiibika 
Published: June 2023

Developing a smart city in Surakarta is to attract domestic and foreign tourists, as well as attract investors to develop infrastructure and open new businesses. The acquisition of foreign exchange is an effort in national development in supporting the national economy, one of which is supported by the tourism sector. This study aims to determine Smart tourism technology on the intention of returning tourists through tourist satisfaction and experiences—direct survey to respondents with quantitative research as the research method. Tourists who visit heritage sites in Surakarta City are the research population. The number of sampling is 200 respondents with a convenience sampling technique. The analytical method used is Structural Equation Modeling using SmartPLS 3.0. The results show that smart tourism technology affects the tourist experience, tourism experience affects tourist satisfaction, tourist satisfaction affects the intention to revisit, and smart tourism technology affects the intention to revisit through tourist experiences and tourist satisfaction in heritage in Surakarta City.

Keywords: Smart tourism technology, tourist experience, tourist satisfaction, revisit intention, heritage.

Abstrak
Pengembangan smart city di Kota Surakarta salah satunya bertujuan untuk menarik wisatawan domestik dan wisatawan mancanegara, serta menarik minat investor dalam pembangunan infrastruktur dan pembukaan bisnis baru. Perolehan devisa negara sebagai upaya dalam pembangunan nasional dalam menyokong perekonomian nasional salah satunya didukung oleh sektor pariwisata. Tujuan penelitian ini untuk mengetahui Smart tourism technology terhadap niat berkunjung kembali wisatawan melalui kepuasaan wisatawan dan pengalaman wisata. survey langsung kepada responden dengan jenis penelitian kuantitatif sebagai metode penelitian ini. Wisatawan yang berkunjung pada wisata heritage di Kota Surakarta adalah populasi penelitian. Jumlah sampel penelitian 200 responden dengan teknik convenience sampling. Metode analisis yang digunakan adalah Structural Equation Modelling menggunakan Smart PLS 3.0. Hasil diperoleh bahwa (1) smart tourism technology berpegaruh terhadap pengalaman wisata, (2) pengalaman wisata berpengaruh terhadap kepuasan wisatawan, (3) kepuasan wisatawan berpengaruh terhadap niat berkunjung kembali dan (4) smart tourism technology berpengaruh terhadap niat berkunjung kembali melalui pengalaman wisata dan kepuasan wisatan di wisata heritage di Kota Surakarta.

Kata kunci: Smart tourism technology, Pengalaman Wisata, Kepuasan Wisatawan, Heritage, Niat Berkunjung Kembali
Pengaruh Kualitas Produk, Iklan dan Citra Merek terhadap Keputusan Pembelian Produk Tolak Angin Sidomuncul di Kota Semarang
Authors: Lorinda Ivanka Prisca , Amron Amron 
Published: June 2023

The purpose of this study is to examine the impact of product quality, advertising and brand image on product purchase decisions in Tolak Angin Sidomuncul, Semarang. An example of this survey is the Tolak Angin consumer, with a total of 100 respondents using non-probabilistic methods. The information gathering procedure adopts a questionnaire survey method. In this study, we adopt the method of multiple regression analysis and use SPSS as the analysis tool. The survey results show that: 1) Product quality influences purchasing decisions for Tlak Angin in Semarang City. 2) Advertising influences purchasing decisions for Tolak Angin in Semarang City. 3) Brand image influences purchase decision of Tolak Angin in Semarang City. 4) Product quality, promotion and brand image all influence the purchase decision of Tolak Angin in Semarang City at the same time.

Keywords: Product Quality, Advertising, Brand Image, Purchase Decisions

Abstrak
Penelitian ini bertujuan guna menguji pengaruh kualitas produk, Iklan, serta Citra Merk terhadap keputusan pembelian produk Tolak Angin Sidomuncul yang terletak di Kota Semarang. Ilustrasi dalam riset ini ialah konsumen Tolak Angin yang berjumlah 100 responden dengan metode Non Probability. Tata cara pengumpulan informasi memakai tata cara Kuesioner Penelitian ini memakai metode Analisis Regresi Linier Berganda dengan mengunakan SPSS selaku perlengkapan analisis. Hasil penelitian menampilkan: 1) Ada pengaruh kualitas produk pada keputusan pembelian Tolak Angin di Kota Semarang. 2) Ada pengaruh Iklan pada keputusan pembelian Tolak Angin di Kota Semarang. 3) Ada pengaruh Citra Merk pada keputusan pembelian Tolak Angin di Kota Semarang. 4) Ada pengaruh kualitas produk, Iklan, serta Citra Merk secara simultan terhadap keputusan pembelian Tolak Angin di Kota Semarang.

Kata kunci: Kualitas Produk, Iklan , Citra Merek, Keputusan Pembelian
Sosialisasi dan Pelatihan Senam Kebugaran Jasmani “Poco-Poco Ceria” Pada KKG Guru PJOK SD Kecamatan Kayuagung Kabupaten Ogan Komering Ilir
Authors: Kristina Putri Cicilia , Oktariyana Oktariyana , Nita Perabu , Putera Yanuar Syam , Akbar Muhammad Taheri , Daryono Daryono , Herlina Ning 
Published: June 2023

Kegiatan Senam Poco-Poco bersama Federasi Olahraga Kreasi Budaya Indonesia (FOKBI) Kota Palembang ini, dalam rangka meningkatkan kemampuan dan kompetensi para Penggiat Olahraga, Guru Penjas, mahasiswa dan Praktisi Olahraga yang ada di kota Palembang dan sekitarnya untuk dapat memiliki keterampilan dalam olahraga senam, Khususnya Senam Poco-poco yang sudah dimasyarakatkan dan dapat bisa dipelajari disekolah selain senam kesegaran jasmani. Maksud tujuan diselenggarakannya kegiatan ini adalah untuk meningkatkan kompetensi keterampilan Mahasiswa, Guru Penjas, Praktisi Olahraga serta masyarakat dalam bidang senam kreasi budaya khususnya senam poco-poco, mengingat senam tersebut sudah lama dikenal dengan masyarakat dari musiknya hingga gerakannya yang mudah untuk dipelajari dari kalangan anak-anak hingga lansia serta bisa dinikmati semua kalangan masyarakat, dan diharapkan dapat menghasilkan penggiat-penggiat senam poco-poco untuk dapat dipersiapkan menghadapi Festival Olahraga Masyarakat Nasional ke 7 di Jawa Barat.
Strategi Digitalisasi Desa Menjadi Desa Modern Kecamatan Cambia Kota Prabumulih
Authors: Purwanto Timur Dali , Paramitha Nina , Agustian Wiwin 
Published: June 2023

TIK diterjemahkan sebagai pemanfaatan teknologi digital. Pemanfaatan teknologi digital dapat membawa desa menjadi desa menjadi desa digital dan modern. Desa modern dimaksudkan sebagai: 1) Mengubah cara orang-orang berbisnis di desa karena Internet sudah memungkinkan untuk digunakan hingga pelosok desa.2) Digital marketing sudah menjadi trend yang semakin menggiatkan perekonomian pedesaan.3) penting bagi desa dalam mengelola komoditi yang dimiliki, dan mengelola jalur distribusi komoditi. 4) penting bagi warga desa untuk memperoleh pengetahuan dan pengalaman dalam hal digitalisasi informasi. Perencanaan pembangunan dapat diimplementasikan secara tepat bila didukung oleh ketersediaan data terkini dan peran serta masyarakat, hingga wilayah kecil yang relevan. Semua stakeholder pembangunan dan masyarakat membutuhkan informasi yang akurat, bersumber dari ujung tombak pembangunan yakni pemerintah desa dan kelurahan. Berdasarkan pada penjabaran di atas maka dipandang perlu untuk melakukan pembaruan desa melalui implementasi TIK menjadi desa digital dan modern.
Pelatihan Penggunaan Aplikasi Buku Tamu pada Balai Pengelola Kereta Api Ringan Sumatera Selatan
Authors: Surya Nugraha Muhammad Chaikal , Sopiah Nyimas , Amalia Rahayu , Ariana Sunda , Oktarina Tri 
Published: June 2023

Sejauh ini di Balai Pengelola Kereta Api Ringan Sumatera Selatan di dalam pengelolaan buku tamu belum ada aplikasinya. Permasalahan yang sering terjadi adalah sering tidak tercatatnya daftar tamu yang berkunjung ke Balai, sehingga menyebabkan tidak terdata tamu yang berkunjung. Tujuan pengabdian ini adalah untuk memudahkan di dalam pengelolaan buku tamu, maka dibuatkanlah aplikasi buku tamu, sehingga diharapkan dapat memudahkan pimpinan untuk mengetahui siapa saja yang berkunjung ke Balai ini. Metode yang digunakan dalam pengabdian ini adalah dengan melakukan sosialisasi dan pelatihan secara langsung terhadap penggunaan aplikasi buku tamu, sehingga tamu dapat memasukkan identitasnya jika berkunjung. Hasil yang diharapkan adalah terciptanya aplikasi buku tamu. Dampak yang dilakukan dengan adanya pengabdian ini adalah pengelolaan lebih efektif terhadap siapa saja yang berkunjung ke Balai ini
Pelatihan Penggunaan Aplikasi Rekam Medis Pada Puskesmas Nagaswidak Berbasis Web
Authors: . Suyanto , Andri Andri , Nasir Muhammad , Supratman Edi , Fatoni Fatoni , Hafidz Ahmad 
Published: June 2023

Pengabdian masyarakat merupakan salah satu pilar dari tri dharma perguruan yang bertujuan membantu masyarakat dengan menerapkan ilmu pengetahuan yang dimilki atau hasil dari penelitian yang dilakukan. Pengabdian masyarakat ini bertujuan memberikan pelatihan kepada pegawai puskesmas dalam memanfaatkan sebuah aplikasi rekam medis berbasis web. Dengan pelatihan ini maka akan memudahkan petugas Puskesmas Nagaswidak dalam bekerja khususnya dalam mengelola data rekam medis pasien. Dalam merancang dan mengembangkan aplikasi rekam medis pasien menggunakan metode waterfall. Analisis data dilakukan dengan teknik kualitatif, mengutamakan data atau gambar yang didapat pada lapangan atau tempat penelitian. Untuk pengambilan data melalui observasi dan wawancara agar aplikasi yang dibuat sesuai dengan yang dibutuhkan. Aplikasi rekam medis berbasis web yang telah dihasilkan diberikan kepada Puskesmas Nagaswidak sebagai bentuk pengabdian peneliti untuk memenuhi satu tri dharma perguruan tinggi.
Impact of cryopreservation on viability, gene expression and function of enteric nervous system derived neurospheres
Authors: Heumüller-Klug Sabine , Maurer Kristina , Tapia-Laliena María Á. , Sticht Carsten , Christmann Anne , Mörz Handan , Khasanov Rasul , Wink Elvira , Schulte Steven , Greffrath Wolfgang , Treede Rolf-Detlef , Wessel Lucas M. , Schäfer Karl-Herbert 
Published: June 2023

Introduction: Impairment of both the central and peripheral nervous system is a major cause of mortality and disability. It varies from an affection of the brain to various types of enteric dysganglionosis. Congenital enteric dysganglionosis is characterized by the local absence of intrinsic innervation due to deficits in either migration, proliferation or differentiation of neural stem cells. Despite surgery, children’s quality of life is reduced. Neural stem cell transplantation seems a promising therapeutic approach, requiring huge amounts of cells and multiple approaches to fully colonize the diseased areas completely. A combination of successful expansion and storage of neural stem cells is needed until a sufficient amount of cells is generated. This must be combined with suitable cell transplantation strategies, that cover all the area affected. Cryopreservation provides the possibility to store cells for long time, unfortunately with side effects, i.e., upon vitality.Methods: In this study we investigate the impact of different freezing and thawing protocols (M1-M4) upon enteric neural stem cell survival, protein and gene expression, and cell function.Results: Freezing enteric nervous system derived neurospheres (ENSdN) following slow-freezing protocols (M1-3) resulted in higher survival rates than flash-freezing (M4). RNA expression profiles were least affected by freezing protocols M1/2, whereas the protein expression of ENSdN remained unchanged after treatment with protocol M1 only. Cells treated with the most promising freezing protocol (M1, slow freezing in fetal calf serum plus 10% DMSO) were subsequently investigated using single-cell calcium imaging. Freezing of ENSdN did not alter the increase in intracellular calcium in response to a specific set of stimuli. Single cells could be assigned to functional subgroups according to response patterns and a significant shift towards cells responding to nicotine was observed after freezing.Discussion: The results demonstrate that cryopreservation of ENSdN is possible with reduced viability, only slight changes in protein/gene expression patterns and without an impact on the neuronal function of different enteric nervous system cell subtypes, with the exception of a subtle upregulation of cells expressing nicotinergic acetylcholine receptors. In summary, cryopreservation presents a good method to store sufficient amounts of enteric neural stem cells without neuronal impairment, in order to enable subsequent transplantation of cells into compromised tissues.
68Ga-labeled WVP peptide as a novel PET probe for molecular biological diagnosis of unstable thoracic aortic aneurysm and early dissection: an animal study
Authors: Lu Xia , Zhu Meilin , Zhao Lingzhou , Qi Feiran , Zou Heng , He Peng , Zhou Haizhong , Shi Kuangyu , Du Jie 
Published: June 2023

ObjectiveType IV collagen (Col-IV) is a prospective biomarker for diagnosing and treating of unstable thoracic aortic aneurysm and dissection (TAAD). This study aims to evaluate the feasibility of 68Ga-labeled WVP peptide (68Ga-DOTA-WVP) as a novel Col-IV-targeted probe for TAAD biological diagnosis using PET/CT.MethodsWVP peptide was modified with bifunctional chelator DOTA for 68Ga radiolabeling. Immunohistochemical staining was used to evaluate the expression and location of Col-IV and elastin in aortas treated with 3-aminopropionitrile fumarate (BAPN) at different time points (0, 2, and 4 weeks). The imaging performance of 68Ga-DOTA-WVP was investigated using Micro-PET/CT in a BAPN-induced TAAD mouse model. The relationship between 68Ga-DOTA-WVP uptake in aortic lesions and the serum levels of TAAD-related biomarkers including D-dimer, C-reactive protein (CRP), and serum soluble suppression of tumorigenicity−2 (sST2) was also analyzed.Results68Ga-DOTA-WVP was readily prepared with high radiochemical purity and stability in vitro. 68Ga-DOTA-WVP Micro-PET/CT could detect Col-IV exposure of unstable aneurysms and early dissection in BAPN-induced TAAD mice, but little 68Ga-DOTA-WVP uptake was shown in the control group at each imaging time point. The differences of Col-IV expression and distribution of 68Ga-DOTA-WVP both in TAAD and control groups further verified the imaging efficiency of 68Ga-DOTA-WVP PET/CT. Additionally, a higher sST2 level was found in the imaging positive (n = 14) than the negative (n = 8) group (9.60 ± 1.14 vs. 8.44 ± 0.52, P = 0.014).Conclusion68Ga-DOTA-WVP could trace the exposure and abnormal deposition of Col-IV in enlarged and early injured aortas, showing a potential for biological diagnosis, whole-body screening, and progression monitoring of TAAD.
Time to clinical improvement: an appropriate surrogate endpoint for pulmonary arterial hypertension medication trials
Authors: Wang An , Chen Mengqi , Zhuang Qi , Guan Lihua , Xie Weiping , Wang Lan , Huang Wei , Cheng Zhaozhong , Yu Shiyong , Zhou Hongmei , Shen Jieyan 
Published: June 2023

BackgroundMany retrospective studies suggest that risk improvement may be a suitable efficacy surrogate endpoint for pulmonary arterial hypertension (PAH) medication trials. This prospective multicenter study assessed the efficacy of domestic ambrisentan in Chinese PAH patients and observed risk improvement and time to clinical improvement (TTCI) under ambrisentan treatment.MethodsEligible patients with PAH were enrolled for a 24-week treatment with ambrisentan. The primary efficacy endpoint was 6-min walk distance (Δ6MWD). The exploratory endpoints were risk improvement and TTCI, defined as the time from initiation of treatment to the first occurrence of risk improvement.ResultsA total of 83 subjects were enrolled. After ambrisentan treatment, Δ6MWD was significantly increased at week 12 (42.2 m, P &lt; 0.0001) and week 24 (53.4 m, P &lt; 0.0001). Within 24 weeks, risk improvement was observed in 53 (64.6%) subjects (P &lt; 0.0001), which is higher than WHO-FC (30.5%) and TAPSE/PASP (32.9%). Kaplan–Meier analysis of TTCI showed a median improvement time of 131 days and a cumulative improvement rate of 75.1%. Also, TTCI is consistent across different baseline risk status populations (log-rank P = 0.51). The naive group had more risk improvement (P = 0.043) and shorter TTCI (log-rank P = 0.008) than the add-on group, while Δ6MWD did not show significant differences between the two groups.ConclusionsDomestic ambrisentan significantly improved the exercise capacity and risk status of Chinese PAH patients. TTCI has a relatively high positive event rate within 24-week treatment duration. Compared to Δ6MWD, TTCI is not affected by baseline risk status. Additionally, TTCI could identify better improvements in patients, which Δ6MWD does not detect. TTCI is an appropriate composite surrogate endpoint for PAH medication trials.Clinical Trial RegistrationNCT No. [ClinicalTrials.gov], identifier [NCT05437224].
Evaluation of Formosa score and diagnostic sensitivity and specificity of four Asian risk scores for predicting intravenous immunoglobulin resistance in Kawasaki disease: a bivariate meta-analysis
Authors: Chiang Wan-Ni , Huang Po-Yu , Kuo Ho-Chang , Huang Ying-Hsien , Chang Ling-Sai 
Published: June 2023

BackgroundIn 2016, Lin et al. developed a prediction score of non-responsiveness to intravenous immunoglobulin (IVIG) in patients with Kawasaki disease (KD) (Lin et al., 2016). Various studies have attempted to validate the Formosa score, but inconsistent results have given us new opportunities and challenges. The aim of this meta-analysis is to explore the role of the Formosa score as a risk score in detecting IVIG-resistant KD patients and then compare the pooled sensitivity and specificity of four Asian risk scores, Egami, Formosa, Kobayashi, and Sano risk scores.MethodsA comprehensive search of Cochrane, Embase, and PubMed was conducted through 20 December 2021, using key terms relevant to the research question “What are the sensitivities and specificities of the four Asian predicting scores, Egami, Formosa, Kobayashi, and Sano, in Kawasaki disease patients with IVIG resistance?” The reference lists of the included studies were manually reviewed to identify pertinent references. A random-effects bivariate model was used to estimate the summary of sensitivity and specificity of the tools.ResultsWe found 41 relevant studies of the four Asian risk scores that were eligible to analyze for pooled accuracy. Eleven studies involving 5,169 KD patients reported the diagnostic performance of the Formosa score for the risk of IVIG resistance. The overall performance of the Formosa score was as follows: pooled sensitivity, 0.60 [95% confidence interval (CI), 0.48–0.70]; pooled specificity, 0.59 (95% CI, 0.50–0.68); and area under the hierarchical summary receiver operating characteristic curve, 0.62. The Formosa score exhibited the highest sensitivity 0.76 (95% CI, 0.70–0.82) for detecting IVIG-resistant KD patients among the 21,389 children included in the 41 studies. In terms of specificity estimates, Formosa had the lowest specificity of 0.46 (95% CI, 0.41–0.51).ConclusionPatients at high risk for IVIG resistance may receive adjunctive treatment to reduce coronary lesions and thus also cardiovascular morbidity. Among all of the included studies, we found Formosa score to have the best sensitivity (0.76) but unsatisfactory specificity (0.46) for predicting IVIG resistance in Kawasaki disease. In the future, network meta-analysis should also incorporate the accuracy of the new scores after they have undergone a certain degree of validation around the world.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, PROSPERO CRD42022341410.
Differential gene expression in the calvarial and cortical bone of juvenile female mice
Authors: Janssen Jerome Nicolas , Kalev-Altman Rotem , Shalit Tali , Sela-Donenfeld Dalit , Monsonego-Ornan Efrat 
Published: June 2023

IntroductionBoth the calvarial and the cortical bones develop through intramembranous ossification, yet they have very different structures and functions. The calvaria enables the rapid while protected growth of the brain, whereas the cortical bone takes part in locomotion. Both types of bones undergo extensive modeling during embryonic and post-natal growth, while bone remodeling is the most dominant process in adults. Their shared formation mechanism and their highly distinct functions raise the fundamental question of how similar or diverse the molecular pathways that act in each bone type are.MethodsTo answer this question, we aimed to compare the transcriptomes of calvaria and cortices from 21-day old mice by bulk RNA-Seq analysis.ResultsThe results revealed clear differences in expression levels of genes related to bone pathologies, craniosynostosis, mechanical loading and bone-relevant signaling pathways like WNT and IHH, emphasizing the functional differences between these bones. We further discussed the less expected candidate genes and gene sets in the context of bone. Finally, we compared differences between juvenile and mature bone, highlighting commonalities and dissimilarities of gene expression between calvaria and cortices during post-natal bone growth and adult bone remodeling.DiscussionAltogether, this study revealed significant differences between the transcriptome of calvaria and cortical bones in juvenile female mice, highlighting the most important pathway mediators for the development and function of two different bone types that originate both through intramembranous ossification.
Lactobacillus gasseri LG08 and Leuconostoc mesenteroides LM58 exert preventive effect on the development of hyperuricemia by repairing antioxidant system and intestinal flora balance
Authors: Liang Lizhen , Meng Zihui , Zhang Fei , Jianguo Zhu , Fang Shuguang , Hu Qingang , Tang Xuna , Li Yanan 
Published: June 2023

IntroductionCurrently, hyperuricemia has shown a surprisingly rising trend, which attracts widespread attention due to potentially major health risks. Considering the inevitable side effects of long-term medicine, probiotics are emerging as potential therapeutics due to their ability to improve uric acid metabolism and superior safety.MethodsIn our study, two strains of probiotics, Lactobacillus gasseri LG08 (LG08) and Leuconostoc mesenteroides LM58 (LM58) isolated from kimchi were evaluated for the prebiotic properties in vitro and uric-lowering effects in vivo. Here, hyperuricemia animal model and 16S rRNA gene amplicons analysis were further studied to investigate whether these probiotics exert different effects in prevention and treatment.ResultsIn vivo indicators and intestinal flora immunity revealed that both LG08 and LM58 significantly prevent the development and progression of hyperuricemia, repair the antioxidant system and maintain intestinal flora balance in healthy rats, especially LM58. After hyperuricemia was formed, although the effect of LG08 and LM58 could decrease the level of uric acid, the effect to reverse and repair antioxidant levels in the body was limited.DiscussionIn our study, these findings have important implications for hyperuricemia prevention and therapy, and provided more mechanistic insights into the effect of probiotics in hyperuricemia.