bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety and depression among patients with non-tuberculous mycobacterial disease in Shanghai: a cross-sectional study
Authors: Ni Sikang , Chen Yuting , Hu Bijie , Yuan Zheng 
Published: May 2023

ObjectiveTo understand the mental health status and its influencing factors among patients with non-tuberculous mycobacterial disease and to provide a reference for medical staff to formulate scientific and feasible intervention strategies.MethodsA total of 114 patients diagnosed with non-tuberculous mycobacillosis during hospitalization in the Department of Infection from September 2020 to April 2021 were selected as the research participants. Participants’ mental health status and related factors were evaluated using a self-made general patient information questionnaire, self-rating Anxiety Scale (SAS), and self-rating Depression Scale (SDS).ResultsAmong 114 patients with non-tuberculous mycosis, 61 (53.51%) exhibited depressive symptoms, and the SDS score was 51.15 ± 13.04, which was higher than the national norm of 41.88 ± 10.57 (p &lt; 0.05); further, 39 patients (34.21%) showed anxiety symptoms, and the SAS score was 45.75 ± 10.81, which was significantly higher than the national norm of 29.78 ± 10.07 (p &lt; 0.05). Body mass index and monthly household income had significant effects on depression in patients with non-tuberculous mycobacterial disease (p &lt; 0.05). Educational level had a significant effect on the anxiety state of patients with non-tuberculous mycobacterial disease (p &lt; 0.05).ConclusionPatients with non-tuberculous mycobacterial disease are prone to depression and anxiety. Nurses should pay attention to it in clinical work for the timely identification of and intervention for anxiety and depression and intervene.
Online art therapy pilot in the Western Isles of Scotland: a feasibility and acceptability study of a novel service in a rural community
Authors: Zubala Ania , Kennell Nicola , MacInnes Catriona , MacInnes Marion , Malcolm Martin 
Published: May 2023

IntroductionArt therapy, despite being an evidence-based, safe and acceptable intervention, is not widely available to clients in Scotland. Online delivery has the potential to expand the reach and accessibility, but special considerations need to be given to designing successful online art therapy services, due to the unique emphasis on the role of an image and artmaking alongside the therapeutic relationship.MethodsA pilot online art therapy service was developed and delivered in the Western Isles of Scotland to individual adult clients wishing to increase their psychological wellbeing. This research aimed to assess feasibility and acceptability of the novel service, identify enablers and challenges in setting up and delivering the service, explore participants’ expectations and experiences of art therapy and identify any impacts of the service. Mixed-method evaluation incorporated questionnaires, focus groups, interviews and Audio Image Recordings (AIRs). Findings were grouped into themes across several key areas: service setup, research procedures, intervention design and impacts and insights. Recommendations were developed for the first three areas and the last section presents indications of change and gives voice to client experience primarily.ResultsOnline art therapy was described by clients as a judgement-free zone which allowed freedom to experiment, express, feel and immerse themselves in the creative flow. Other benefits included readiness to accept emotions, increased understanding of self and others and being able to see things from a new perspective. Clients recognised the unique nature of art therapy in relation to other psychological treatments and valued the freedom of expression it offered, including the non-verbal.DiscussionThis project demonstrated that online art therapy is not only a feasible an acceptable intervention, but potentially also a powerfully impactful one, capable of instilling a positive change in a surprisingly short period of time. Exploring ways to expand current and introduce new art therapy services is highly recommended. Refinement of an intervention design, tools and research procedures is recommended through further feasibility studies of a larger scale.
Intraoperative electrophysiological monitoring determines the final electrode position for pallidal stimulation in dystonia patients
Authors: Baláž Marek , Búřil Jiří , Jurková Tereza , Koriťáková Eva , Hrabovský Dušan , Kunst Jonáš , Bártová Petra , Chrastina Jan 
Published: May 2023

BackgroundBilateral deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective treatment for refractory dystonia. Neuroradiological target and stimulation electrode trajectory planning with intraoperative microelectrode recordings (MER) and stimulation are used. With improving neuroradiological techniques, the need for MER is in dispute mainly because of the suspected risk of hemorrhage and the impact on clinical post DBS outcome.ObjectiveThe aim of the study is to compare the preplanned GPi electrode trajectories with final trajectories selected for electrode implantation after electrophysiological monitoring and to discuss the factors potentially responsible for differences between preplanned and final trajectories. Finally, the potential association between the final trajectory selected for electrode implantation and clinical outcome will be analyzed.MethodsForty patients underwent bilateral GPi DBS (right-sided implants first) for refractory dystonia. The relationship between preplanned and final trajectories (MicroDrive system) was correlated with patient (gender, age, dystonia type and duration) and surgery characteristics (anesthesia type, postoperative pneumocephalus) and clinical outcome measured using CGI (Clinical Global Impression parameter). The correlation between the preplanned and final trajectories together with CGI was compared between patients 1–20 and 21–40 for the learning curve effect.ResultsThe trajectory selected for definitive electrode implantation matched the preplanned trajectory in 72.5% and 70% on the right and left side respectively; 55% had bilateral definitive electrodes implanted along the preplanned trajectories. Statistical analysis did not confirm any of the studied factors as predictor of the difference between the preplanned and final trajectories. Also no association between CGI and final trajectory selected for electrode implantation in the right/left hemisphere has been proven. The percentages of final electrodes implanted along the preplanned trajectory (the correlation between anatomical planning and intraoperative electrophysiology results) did not differ between patients 1–20 and 21–40. Similarly, there were no statistically significant differences in CGI (clinical outcome) between patients 1–20 and 21–40.ConclusionThe final trajectory selected after electrophysiological study differed from the preplanned trajectory in a significant percentage of patients. No predictor of this difference was identified. The anatomo-electrophysiological difference was not predictive of the clinical outcome (as measured using CGI parameter).
Ambient Melting Behavior of Stoichiometric Uranium-Plutonium Mixed Oxide Fuel
Authors: Burakovsky Leonid , Ramsey Scott D. , Baty Roy S. 
Published: May 2023

Mixed oxides of uranium and plutonium (MOX) are currently considered as a reference fuel for the new generation of fast breeder reactors such as ASTRID. The key factor determining the performance and safety of a fuel such as MOX is its operational limits in the application environment which are closely related to the material’s structure and thermodynamic stability. They are in turn closely related to the ambient (zero pressure) melting point (Tm); thus, Tm is an important engineering parameter. Furthermore, PuO2 and UO2 are two endpoints of the phase diagram of MOX; therefore, their ambient Tms are fundamental reference points. However, the current knowledge of the Tm of MOX is limited and controversial as several studies available in the literature do not converge on the unique behavior of Tm as a function of x. Specifically, some studies produced Tm as a monotonically decreasing function of x such that, with Tm of UO2(x=0) of 3150 K, Tm of PuO2(x=1) is ∼2650 K, while other studies resulted in Tm having a local minimum at 0.5<x<1 such that Tm of PuO2 is ∼3000 K, so that the difference between the two values of Tm is as high as 350 K. In this study, using the ab initio Z method implemented with the Vienna Ab Initio Simulation Package (VASP), we carry out a suite of quantum molecular dynamics simulations to obtain the ambient Tm of MOX at several values of x, 0<x<1, including the two end points (x=0, x=1). Our results agree with the behavior of Tm of MOX as a function of x having a local minimum at x=0.7 and Tm of PuO2 of 3050 K. Our study suggests potential ambient density–melting point systematics of MOX which may be useful in subsequent research on MOX such as its thermoelasticity modeling.
Vaccines against Tuberculosis: Where Are We Now?
Authors: Srivastava Shruti , Dey Sajal , Mukhopadhyay Sangita 
Published: May 2023

Tuberculosis (TB) is among the top 10 leading causes of death in low-income countries. Statistically, TB kills more than 30,000 people each week and leads to more deaths than any other infectious disease, such as acquired immunodeficiency syndrome (AIDS) and malaria. TB treatment is largely dependent on BCG vaccination and impacted by the inefficacy of drugs, absence of advanced vaccines, misdiagnosis improper treatment, and social stigma. The BCG vaccine provides partial effectiveness in demographically distinct populations and the prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB incidences demands the design of novel TB vaccines. Various strategies have been employed to design vaccines against TB, such as: (a) The protein subunit vaccine; (b) The viral vector vaccine; (c) The inactivation of whole-cell vaccine, using related mycobacteria, (d) Recombinant BCG (rBCG) expressing Mycobacterium tuberculosis (M.tb) protein or some non-essential gene deleted BCG. There are, approximately, 19 vaccine candidates in different phases of clinical trials. In this article, we review the development of TB vaccines, their status and potential in the treatment of TB. Heterologous immune responses generated by advanced vaccines will contribute to long-lasting immunity and might protect us from both drug-sensitive and drug-resistant TB. Therefore, advanced vaccine candidates need to be identified and developed to boost the human immune system against TB.
Identification of frailty in primary care: accuracy of electronically derived measures
Authors: Swart Karin MA , van der Heijden Amber AWA , Blom Marieke T , Overbeek Jetty A , Nijpels Giel , van Hout Hein PJ , Elders Petra JM , Herings Ron MC 
Published: May 2023

BackgroundRoutinely collected clinical data based on electronic medical records could be used to define frailty.AimTo estimate the ability of four potential frailty measures that use electronic medical record data to identify older patients who were frail according to their GP.Design and settingThis retrospective cohort study used data from 36 GP practices in the Dutch PHARMO Data Network.MethodThe measures were the Dutch Polypharmacy Index, Charlson Comorbidity Index (CCI), Chronic Disease Score (CDS), and Frailty Index. GPs’ clinical judgement of patients’ frailty status was considered the reference standard. Performance of the measures was assessed with the area under the receiver operating characteristic curve (AUC). Analyses were done in the total population and stratified by age and sex.ResultsOf 31 511 patients aged ≥65 years, 3735 (11.9%) patients were classified as frail by their GP. The CCI showed the highest AUC (0.79, 95% confidence interval [CI] = 0.78 to 0.80), followed by the CDS (0.69, 95% CI = 0.68 to 0.70). Overall, the measures showed poorer performance in males and females aged ≥85 years than younger age groups (AUC 0.55–0.58 in females and 0.57–0.60 in males).ConclusionThis study showed that of four frailty measures based on electronic medical records in primary care only the CCI had an acceptable performance to assess frailty compared with frailty assessments done by professionals. In the youngest age groups diagnostic performance was acceptable for all measures. However, performance declined with older age and was least accurate in the oldest age group, thereby limiting the use in patients of most interest.
Factors associated with the consultation of GPs among adults aged ≥16 years: an analysis of data from the Health Survey for England 2019
Authors: Song Fujian , Bachmann Max , Howe Amanda 
Published: May 2023

BackgroundUnderstanding the factors associated with demands for general practice care is crucial for policy decision makers to appropriately allocate healthcare resources.AimTo investigate factors associated with the frequency of GP consultations.Design & settingData on 8086 adults aged ≥16 years was obtained from cross-sectional Health Survey for England (HSE) 2019.MethodThe primary outcome was the frequency of consultations of a GP in the last 12 months. Multivariable ordered logistic regression analysis was used to evaluate associations between GP consultations and a range of sociodemographic and health-related factors.ResultsFrequency of GP consultations for all reasons was higher among females (odds ratio [OR] 1.81, 95% confidence interval [CI] = 1.64 to 2.01), those aged ≥75 years (OR 1.48, 95% CI = 1.15 to 1.92), ethnic minority populations (Black: OR 1.42, 95% CI = 1.09 to 1.84; Asian: OR 1.53, 95% CI = 1.25 to 1.87), lowest household income (OR 1.53, 95% CI = 1.29 to 1.83), adults with long-lasting illnesses (OR 3.78, 95% CI = 3.38 to 4.22), former smokers (OR 1.17, 95% CI = 1.04 to 1.22), being overweight (OR 1.14, 95% CI = 1.01 to 1.29), and being obese (OR 1.32, 95% CI = 1.16 to 1.50). Predictors of consultations for physical health problems were similar to predictors of consultations for any health problems. However, younger age was associated with more consultations for mental health problems, or a combination of mental and physical health problems.ConclusionThe higher frequency of consultation of GPs is associated with female sex, older age, ethnic minority populations, being socioeconomically disadvantaged, existence of lasting illnesses, smoking, being overweight, and being obese. Older age is associated with increased consultations for physical health problems, but associated with reduced consultations for mental health or a combination of mental and physical health problems.
Analisis Ketersediaan Air Upaya Pemenuhan Kebutuhan Air Bersih di Desa Tinawun Kecamatan Malo Kabupaten Bojonegoro
Authors: Mushthofa Mushthofa , Candrasasi Dian , Roehman Fatchur 
Published: May 2023

Air adalah kebutuhan vital untuk keberlangsungan hidup setiap makhluk di bumi. Tanpa adanya air di bumi maka kehidupan tidak akan pernah ada). Tingkat kebutuhan air di setiap daerah pasti berbeda yang disebabkan oleh tingkat penggunaan dan jumlah penduduk di daerah tersebut. Begitu pula kebutuhan air bersih di Kabupaten Bojonegoro yang berfariatif di setiap wilayahnya termasuk di Desa Tinawun Kecamatan Malo Kabupaten Bojonegoro. Tujuan dilakukannya penelitian ini adalah untuk mengetahui perkiraan jumlah penduduk Desa Tinawun tahun 2030 dikaitkan dengan kebutuhan air bersih di Desa Tinawun pada tahun 2030. Metode perhitungan menggunakan aritmatik, geometrik dan regresi linier. Hasil dari penelitian ini bahwa Jumlah penduduk Desa Tinawun pada tahun 2030 diprediksi sebanyak 1.867 Jiwa, Sedangkan untuk jumlah pelanggan pengguna air WISLIC pada tahun 2030 diperkirakan sebanyak 124 SR atau diperkirakan sebnayak 1,275 jiwa. Prediksi kebutuhan air Desa Tinawun berdasarkan jumlah prediksi penduduk pada tahun 2030 sebanyak 1,789 Liter/detik, Untuk prediksi kebutuhan air berdasarkan jumlah pelanggan pada tahun 2030 sebanyak 0,955 liter/detik. Sedangkan ketersedian air Sendang Sejahtera yang dari hasil penelitian didapat hasil 0,919 liter/detik, sehingga untuk mencukupi kebutuha air ditahun 2030 memiliki kekurangan air sebanyak 0,036 liter/detik.
analisis kinerja simpang tiga ruas jalan sunan kudus-jalan kyai telingsing, kabupaten kudus
Authors: Widodo Slamet 
Published: May 2023

Kabupaten Kudus adalah Kabupaten yang terletak di Provinsi Jawa Tengah, Indonesia. Jalan Sunan Kudus adalah jalan yang menghubungkan Kabupaten Kudus dan Kabupaten Jepara. Jalan tersebut adalah jalur cepat karena merupakan jalur lokal. Tidak hanya mobil dan motor yang menggunakan jalur tersebut, truk dan bus juga menggunakan jalur tersebut sebagai jalur utama. Simpang Tak Bersinyal ini merupakan simpang yang menghubungkan Jalan Sunan Kudus dan Jalan Kyai Telingsing. Jalan Sunan Kudus sebagai Jalan Utama dan Jalan Kyai Telingsing sebagai jalan minornya. Kondisi simpang tersebut termasuk simpang yang cukup padat dikarenakan jalan utama digunakan sebagai penghubung antar Kabupaten, selain itu juga digunakan sebagai akses untuk menuju makam Sunan Kudus dan Masjid Menara Kudus. Maka pelayanan untuk wisatawand dan peziarah yang berasal dari luar kota maupun dalam kota yang melalui simpang tersebut berpotensi mengalami kemacetan. Survei dilaksanakan menggunakan teknik manual dalam proses pengambilan data dilapangan. Analisis ini menggunakan teknik perhitungan metode MKJI 1997.
Virtus et Fortuna : le général et l’armée au combat chez Tacite
Authors: Autin Louis 
Published: May 2023

As many other ancient historians, Tacitus is familiar with the concepts of uirtus and
fortuna, which have been broadly used as a key for reading history during the Hellenistic period and as a mean of representing battles in Rome. Yet, although occasionally employed in their traditional sense ¢ namely that the soldier’s intrinsic merit, i. e. his bravery, must go hand in hand with the extrinsic manifestation of luck ¢, those notions are most of the time given a completely different meaning in his works. Indeed, the system they formmerges with another mostly tacitean dichotomy between individual and collective. In this new ideological configuration, the unpredictable events - fortuna - are caused by the irrational behaviour of the crowd, while, facing the mob, only the commander can and must show his uirtus, being then defined as a sort of practical intelligence.
Pura oratio (Heaut. v. 46) : où se cache le discours dans l’Heautontimoroumenos ?
Authors: Faure-Ribreau Marion 
Published: May 2023

After an overlook on the different ways Heaut. 46 has been understood, this article explains the meaning of the words pura oratio by putting them into a double context : the meanings and uses of the word oratio in Plautus and Terence’s comedies, and the prologue of the Heautontimoroumenos, where Terence makes fun by referring to the judicial context. The two meanings of oratio which can be brought out ¢ oratio as verbal interaction aiming to be efficient, and as rhetorical speech said by an orator (meaning that seems not to appear in Plautus’ comedies but in Terence’s) ¢ allow us to explain the words
pura oratio and the interactions between the characters of the Heautontimoroumenos
using a double point of view, combining rhetoric with playfulness.
Finite Element Analysis on the Arms of Multirotor UAV
Authors: Abuzar Ulla Khan  , Justus Shadrach J  , Karan H  , Vamshi B  , Bhushan JK  , Nishanth P  
Published: May 2023

As the development and applications of UAV is been increasing significantly in various fields. The main focus is towards the design and structural analysis of the UAV. As the initial step of initialization of any UAV prior condition is to design.
The structural analysis of a UAV frame is important since it has to withstand the forces due to aerodynamic and gravitational forces due to the mounted weights. As design optimisation plays an important role for an efficient structure, a finite element analysis provides an efficient methodology to meet the desired objectives related to structural elements. This project mainly focuses on the structural loads and vibrations acting on the arms of multirotor UAV.
Finite element analysis is been carried out on the arms of multirotor UAV to understand the structural loads acting on the arms of the UAV. A small deformation occurred on the arms are safe and within the limit. Therefore, this study aimed to analyse the strength and durability of UAV arms during the in-flight conditions through the analysis.
Analisa Faktor Waktu Tunggu Pelayanan Resep di Rumah Sakit Pekanbaru Medical Center
Authors: Mulya Adrian , Ennimay Ennimay , Devis Yesica 
Published: May 2023

Abstrak: Hasil Walk Through Audit (WTA) BPJS menyatakan layanan waktu tunggu obat di Rumah Sakit Pekanbaru Medical Center merupakan salah satu faktor keterlambatan layanan terhadap pasien. Setelah dilakukan studi pendahuluan didapatkan data waktu tunggu obat melebihi dari nilai Standar Pelayanan Miminum waktu tunggu obat. Tujuan penelitian ini menganalisa faktor-faktor yang mempengaruhi waktu tunggu pelayanan resep obat pasien rawat jalan di Rumah Sakit Pekanbaru Medical Center. Penelitian ini menggunakan Mixed-Methods Sequential Explanatory Design yakni dengan mengkombinasikan metode deskriptif kuantitatif dan kualitatif. Dari 70 sampel didapatkan data hasil penelitian kuantitatif untuk jenis pasien, jenis resep, jumlah item dalam resep, jumlah resep dalam shift dan jumlah resep berdasarkan ketersediaan obat bukan merupakan faktor-faktor yang mempengaruhi waktu tunggu pelayanan resep obat pasien rawat jalan, hal ini berdasarkan Uji Chi-Square semua nilai > 0,05, ini berarti bahwa Ho ditolak atau dengan kata lain tidak terbukti berhubungan dengan waktu tunggu layanan. Sedangkan penelitian kualitatif dengan wawancara secara mendalam dan observasi dengan hasil jumlah SDM yang tidak mencukupi, kurangnya kompetensi SDM , belum jelasnya alur proses layanan, belum memadai sarana dan prasarana terutama sistem jaringan Sim-PEC dan Tata ruangan instalasi farmasi yang belum sesuai standar menyebakan terjadinya delay layanan atau lamanya waktu tunggu pelayan obat pasien rawat jalan.
Aktivitas Antioksidan Ekstrak Daun, Bunga, dan Tangkai Sirih Hutan (Piper aduncum L.)
Authors: Mariani Ria , Perdana Farid , Widiana Revi 
Published: May 2023

Abstrak: Sirih Hutan (Piper aduncum L.) termasuk tumbuhan genus Piper. Penelitian antioksidan berbagai genus Piper telah banyak dilakukan seperti Piper crocatum dan Piper betle, namun penelitian antioksidan pada sirih hutan masih sangat terbatas. Antioksidan alami dapat dimanfaatkan untuk meredam radikal bebas dalam upaya mencegah penyakit degeneratif. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan pada bunga, daun dan tangkai sirih hutan serta kelompok senyawa yang bertanggung jawab terhadap aktivitas antioksidan tersebut. Aktivitas antioksidan diuji menggunakan metode DPPH (2,2 difenil-1-pikrilhidrazil) dengan spektrofotometri UV-Vis dan kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa uji aktivitas antioksidan menggunakan spektrofotometri UV-Vis, pada ekstrak daun sirih hutan memiliki nilai IC50 47,252 μg/ml, pada ekstrak bunga sirih hutan dengan nilai IC50 49,756 μg/m, dan pada ekstrak tangkai sirih hutan dengan nilai IC50 48,674 μg/ml. Sedangkan vitamin C sebagai pembanding memiliki nilai IC50 5,223 μg/ml. Dari hasil KLT, senyawa yang diduga memberikan aktivitas antioksidan pada ekstrak bunga dan tangkai adalah senyawa flavonoid karena memiliki nilai Rf yang sama yaitu 0,35;0,53;0,66 pada hasil plat yang telah disemprot DPPH dan sitroborat. Ekstrak daun, bunga dan tangkai sirih hutan memiliki aktivitas antioksidan dengan IC50 berturut-turut 47,252; 49,756 dan 48,674 μg/ml serta diduga adanya senyawa flavonoid yang bertanggung jawab terhadap aktivitas antioksidan ekstrak bunga dan tangkai.