bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of ultrasound and dopplerometric endometry examination in autoimmune thyroiditis patients with abnormal uterine bleeding
Authors: Alieksieieva O. , Lazurenko V. , Vasylieva I. , Afanasiev I. , Kudin I. , Harkavenko K. 
Published: April 2023

Abnormal uterine bleeding occurs in 10–30% of reproductive age women. Ultrasound examination is one of the most effective methods of diagnosing lesions of the pelvic organs while it has high sensitivity (96%), but low specificity (13.8%) in relation to endometrial lesions, the informativeness of ultrasound in the diagnosis of abnormal uterine bleeding ranges from 60 to 93.3%. It had been revealed revealed that the imbalance of thyroid hormones can have a direct effect on the endometrium. Thus, the analysis of ultrasound examinations data together with dopplerometric assessment of the blood flow of the internal genital organs in autoimmune thyroiditis patients with abnormal uterine bleeding is an urgent task of modern gynecology. The purpose is to determine the features of ultrasound exanimation with Doppler assessment of the endometrium in autoimmune thyroiditis patients with abnormal uterine bleeding. Materials and methods. The patients’ examinations were carried out from 2019 to 2022 We examined 120 patients, of whom 90 (75%) suffered from abnormal uterine bleeding and 30 (25%) did not have signs of gynecological and somatic pathology (control group). Abnormal bleeding patients average age was 36.3±3.2 years. The average age of bleeding and thyroid pathology women was 34.8±2.6 years, the control group average age was 30.7±2.9 years. Results. Echographic signs of endometrium structural changes were detected in 83 (92.2%) of abnormal nautoimmune bleeding women and in 7 (7.8%) women ultrasound signs of pathology were not detected. Significant differences were found when analyzing the results of ultrasonographic examination of patients with bleeding and bleeding + thyroid pathology. Conclusion. Ultrasound is an important method that contributes to a significant improvement in the diagnosis of isolated or combined benign uterine diseases in women with abnormal autoimmune bleeding at the background of thyroid pathology, and in most cases corresponds to the histological diagnosis.
Monoclonal antibodies blocking CGRP for prevention of migraine
Authors: Maziarczyk Alicja , Miazga Dominika , Surdacka Laura 
Published: April 2023

Introduction and purpose
Monoclonal antibodies blocking calcitonin gene-related peptide (CGRP) are a novel treatment strategy developed specifically for prevention of migraine. Four drugs belong to this group: eptinezumab, fremanezumab and galcanezumab, which bind to the peptide; and erenumab, which blocks the CGRP receptor. CGRP is involved in nociception and plays a crucial role in the pathophysiology of migraine, as it is released in the trigeminal ganglion as a response to local cerebral vasoconstriction in order to cause dilation of the vessels and maintain cerebral blood flow. Moreover, administration of CGRP, especially among migraineurs, induces a migraine-type headache. The aim of the paper is to discuss the potential of monoclonal antibodies blocking CGRP for the prevention of migraine and to outline their safety and efficacy profile.
State of knowledge
Several randomised clinical trials have shown a significant efficacy of these drugs compared to placebo in reducing monthly migraine affected days, among patients suffering from both episodic and chronic migraine. Incidence rate of side effects is low; the most common were mild to moderate (e.g. pain at the injection site, upper respiratory tract infections, nasopharyngitis, back pain and urinary tract infection). Anti-CGRP monoclonal antibodies exhibit a superior benefit-to-risk ratio than established preventive treatments.
Conclusions
Randomized controlled trials are still needed in order to compare different anti-CGRP monoclonal antibodies and asses their long-term safety profile. In conclusion, these drugs seem to provide promising prospects of improving the lives of migraineurs. As based on current knowledge, the benefits are superior to the likelihood of harm.
Mindfulness based interventions in the treatment of obesity
Authors: Winiarz Aleksandra , Wokurka Wojciech , Turek Michał , Szlendak Paula , Toś Katarzyna , Wojtala Kacper , Grosman Sylwia , Węgrzyniak Agata , Drobek Dominik , Wąsala Katarzyna 
Published: April 2023

Introduction: Obesity is a chronic, multifactorial disease that leads to many complications. Many methods of treating obesity are available, but they are often not effective enough. Due to the strong connection between psychological factors and the development of obesity, it can be useful to include mindfulness training in treatment.
The aim of this study: Summarize current knowledge on the effectiveness of mindfulness training in the treatment of obesity and evaluate the effect of mindfulness on weight loss.
Material and method: The review includes publications published in 2012-2022. The search of publications in the Pubmed database was carried out using the following keywords: mindful eating, mindfulness, weight loss, obesity.
Description of the stage of the knowledge: The use of mindfulness techniques in the treatment of eating disorders is becoming more popular. A growing number of studies evaluating the effects of mindfulness on weight loss are emerging, but the results are inconclusive. Mindfulness training is effective in improving eating habits and promoting lifestyle changes. Mindfulness training combined with behavioral treatments for obesity has positive effects on weight loss.
Summary: Research shows that mindfulness training may be a promising intervention in obesity treatment because it increases self-awareness and promotes lifestyle changes. However, more research is needed to assess the long-term effectiveness of mindfulness for weight control.
TINU syndrome - literature review
Authors: Sowiński Wojciech , Zdybel Michał , Kamińska Magdalena , Strzoda Adam , Strzoda Anna , Strzoda Agata , Rojek Kornelia , Juda Agata 
Published: April 2023

Introduction
Tubulointerstitial nephritis with uveitis (TINU syndrome) is a rare condition which mainly affects young females. The pathomechanism of the TINU has not been still well understood but autoimmune background is suspected. Although it was first described in 1975, less than 600 cases have been reported so far.
Aim of the study
The aim of the study is to present the current knowledge about the TINU syndrome.
Material and methods
The article was created based on the PubMed database. Articles were searched in English using the following keywords: TINU syndrome, tubulointerstitial nephritis, uveitis.
Results
TINU syndrome occurs in 0.1-2% of patients with uveitis with no ethnic preferences. It has been linked to a number of potential causes including infectious, genetic, and jatrogenic factors. Clinical manifestation is often atypical what leads to underdiagnosis of disease. There are currently no established specific guidelines on the basis of which a diagnosis of TINU syndrome can be made. Therapy includes topical treatment and systemic corticosteroid therapy. The overall prognosis for patients is favorable, but it is possible to develop chronic kidney disease especially in adults.
Summary:
TINU syndrome remains a poorly understood disease and is often not taken into account in the diagnostic process. The lack of general treatment standards means that therapy is not always effective. Further research is needed to establish guidelines for the management of this disease.
The short-term impact of non-removable offloading devices on quality of life in people with recurrent diabetic foot ulcers
Authors: Delpierre Thomas , McCormick Keith , Backhouse Michael R , Bruce Julie , Cherry Lindsey 
Published: April 2023

Objective:Recurrent diabetic foot ulcers (DFUs) are associated with poor health-related quality of life and reduced mobility. Current guidelines recommend application of non-removable offloading devices (NROLDs) as they may improve the healing of DFUs, but there is a lack of information on the wider effects of wearing these devices. Few studies have examined the impact of NROLDs on holistic wellbeing or physical activity. We aimed to investigate the short-term impact of NROLDs on physical activity and DFU-related quality of life (DFU-QoL) in a small sample of community-dwelling people with recurrent DFUs.Method:We measured DFU-QoL and physical activity (GPAQ) in people with DFUs, recruited from a single clinic before NROLD application, and at three and six weeks after device fitting. Participants were aged from 39–81 years (mean 58.4±10.1 years) with an equal number of male and female participants.Results:The study cohort comprised 18 participants, of whom 14 (78%) completed six-week questionnaires. Although there was some interim decline observed within individual domains of the DFU-QoL (financial: mean difference (MD) 16.2 (95% confidence interval (CI) 2.1, 30.2); p=0.03); non-compliance: MD 12.5 (95% CI–0.2, 25.2); p=0.05), no differences were observed over six weeks. Levels of physical activity declined over time, with over half (56%) of participants classified as having low levels of physical activity at baseline, rising to two-thirds (67%) at follow-up.Conclusion:Future studies should explore the longer-term holistic impact of NROLDs and develop more personalised approaches to care at the point of prescription, during and post-device use.
New antioxidant therapy for hard-to-heal neuroischaemic diabetic foot ulcers with deep exposure
Authors: Pérez-Zabala Elena , Basterretxea Andima , Castro Begoña , Aizpuru Alfonso , Arancon Jose Antonio , Moreno Carla , Zubizarreta Arrate , Larizgoitia Zohartze , Ysa August , Lobato Marta , Larrazabal Ainara 
Published: April 2023

Objective: To evaluate the clinical efficacy of a new antioxidant therapy for the treatment of complex neuroischaemic diabetic foot ulcers (DFUs). Method: A prospective case series study has been conducted in patients with complex neuroischaemic DFUs after transmetatarsal amputation. DFUs were locally treated with an antioxidant dressing twice a week for the first two weeks, and then once a week until the end of the study or complete wound closure. Patients were followed-up for eight weeks and assessed weekly to analyse wound outcome. Primary outcomes were the wound closure ratio and percentage of granulation tissue; secondary outcomes were parameters related to wound management, namely, presence of non-viable tissue in the wound bed, levels of maceration and exudates, presence of erythema and pain. Results: A total of 20 patients were included with a mean baseline wound area of 20.4cm2. At 8 weeks, the mean reduction in wound area was 88.1% (p<0.0001) and complete closure was observed in 33% of cases. In addition, there was a mean increase of 94.7% in granulation tissue in the wound bed (p<0.0001). Furthermore, the therapy was associated with a significant percentage reduction in wounds with non-viable tissue, good exudate management, and the maintenance of low levels of maceration, erythema and pain. Conclusion: The new antioxidant therapy was associated with good clinical outcomes in large hard-to-heal neuroischaemic DFUs, with significant wound area reduction and granulation tissue formation. The therapy was also found to be safe and perform well from a practical perspective.
Cold plasma treatment is safe for diabetic foot ulcers and decreases Staphylococcus aureus bacterial load
Authors: Lagrand Rimke S , Sabelis Louise WE , de Groot Vincent , Peters Edgar JG 
Published: April 2023

Aim: Cold atmospheric plasma (CAP) has antimicrobial properties. We studied the safety of a novel CAP device (PLASOMA prototype; Plasmacure, The Netherlands) that is simple to use and could be applied at a patient's home for the treatment of diabetic foot ulcers (DFUs). Secondary objectives were to investigate the effect of CAP on bacterial load and on ulcer size. Method: We included subjects with non-infected, superficial DFUs and treated them with CAP on a daily basis for 10 days. The primary endpoint was the occurrence of serious adverse device effects (SADE). We defined safety as: ≤10% of patients experiencing a SADE other than infection (non-infectious SADE), and ≤60% of patients developing infection of the foot (infectious serious adverse event (SAE)). Results: We enrolled 20 patients. No SADE occurred, but three infectious SAEs occurred at the site of application within one month of treatment; three SAEs unrelated to treatment occurred, and 55% of subjects reported transient mild adverse device effects. Staphylococcus aureus bacterial load decreased directly after CAP application (p=0.01). The mean decrease of ulcer surface area was 43% (95% confidence interval: 20.2%–65.9%). Conclusion: CAP treatment in DFUs was safe and well tolerated. Ulcer size and Staphylococcus aureus colonisation decreased during treatment.
Nurses' knowledge and practice in preventing pressure injuries in intensive care units
Authors: Kaçmaz Hatice Yüceler , Ceyhan Özlem , Güler Hüseyin Burak , Balcılar Fadime 
Published: April 2023

Objective: Globally, pressure injuries (PIs) are an important problem affecting healthcare institutions and patients. Nurses in multidisciplinary teams, play a crucial role in preventing PIs. Nurses working in intensive care units (ICUs) provide care to patients who are at risk of developing PIs. The aim of this study was to ascertain the knowledge and practices of intensive care nurses in preventing PIs, and to highlight the relationship between this knowledge and the prevalence of PIs. Method: This study used a descriptive and correlational design. It was carried out in the level 3 ICU of a university hospital in Kayseri, Turkey. A total of four instruments were used at the data collection stage: a nurse information form; the PI prevention knowledge assessment instrument; PI prevention practices; and a PI Prevalence Form. Results: The population of the study consisted of 111 nurses, 91 (82%) of whom fully participated. The mean score of the nurses' knowledge in preventing PIs was found to be 43.2±11.4%. The most common answer regarding the clinical use of PI prevention practices was: ‘always applied’. There was no relationship between PI prevalence and PI prevention knowledge scores of the ICU nurses. Conclusion: In this study, it was observed that although nurses reported incorporating PI prevention practices in ICUs, their related knowledge level was insufficient.
Use of negative pressure wound therapy on locoregional flaps: a case–control study
Authors: Yuan Kong , Quah Alison , Hwee Jolie , Xu Roland , Yijun Wu , Wen Ng Hui , Han Pek Chong 
Published: April 2023

Objective: The use of negative pressure wound therapy (NPWT) is ubiquitous in the management of complex wounds. Extending beyond the traditional utility of NPWT, it has been used after reconstructive flap surgery in a few case series. The authors sought to investigate the outcomes of NPWT use on flap reconstruction in a case–control study. Method: Patients who underwent flap reconstruction between November 2017 and January 2020 were reviewed for inclusion in the study, and divided into an NPWT group and a control group. For patients in the NPWT group, NPWT was used directly over the locoregional flap immediately post-surgery for 4–7 days, before switching to conventional dressings. The control group used conventional dressing materials immediately post-surgery. Outcome measures such as flap necrosis, surgical site infections (SSIs), wound dehiscence as well as time to full functional recovery and hospitalisation duration were evaluated. Results: Of the 138 patients who underwent flap reconstruction, 37 who had free flap reconstructions were excluded, and 101 patients were included and divided into two groups: 51 patients in the NPWT group and 50 patients in the control group. Both groups had similar patient demographics, and patient and wound risk factors for impaired wound healing. Results showed that there was no statistically significant difference between flap necrosis, SSIs, wound dehiscence, hospitalisation duration as well as functional recovery rates. Cost analysis showed that the use of NPWT over flaps for the first seven postoperative days may potentially be more cost effective in our setting. Conclusion: In this study, the appropriate use of NPWT over flaps was safe and efficacious in the immediate postoperative setting, and was not inferior to the conventional dressings used for reconstructive flap surgery. The main benefits of NPWT over flaps include better exudate management, oedema reduction and potential cost savings. Further studies would be required to ascertain any further benefit.
Do diabetes-related foot ulcer wound fluid measures have clinical utility as biomarkers for healing? A systematic review
Authors: Longfield Matilda SG , Lourdesamy Jacintha , Min Danqing , Twigg Stephen M 
Published: April 2023

Objective: This study aimed to identify potential biomarkers reported in wound fluid of diabetes-related foot ulcers (DRFUs), and their ability to reflect current and prospective wound healing. Method: A systematic search was executed following the PRISMA methodology across five chosen databases: MEDLINE, Embase, Scopus, Cochrane Clinical Trials and Cochrane Systematic Reviews. Using keywords and phrases, it yielded 5022 results. Results: Based on predetermined inclusion and exclusion criteria, 19 papers were included in the final analysis, among which: seven reported serial temporal biomarker changes in wounds; six reported measures from baseline and related them to healing rate and/or final healing outcome; four papers reported both end-points, and two papers reported solely on baseline biomarker levels in a generalised diabetic foot ulcer group. Across the studies, a total of 46 distinct markers were described from the wound fluid of n=1141 participants. Biomarkers examined included proteases, protease inhibitors, growth factors, chemokines and cytokines, with proteases being the largest subcategory making up 16 (34.8%) of the markers investigated (n=7). Matrix metalloproteinase-9 (MMP-9) was the most frequently investigated protease and it currently holds the most biomarker promise (n=5). Wound bacterial profiles variably related to wound healing outcome (n=5). One study reported biophysical markers rather than biomarkers, including measurement of wound fluid pH. Study quality was generally good. Drawing quantitative comparisons between papers was not possible due to variability in experimental design including sampling and assessment methods. Conclusion: These studies collectively indicate several wound fluid measures that could identify DRFU status and outcomes, and that methodological standardisation in the field is needed to determine reliable predictive thresholds for healing.
Phylogenetic of red snapper (Lutjanidae) in Yapen Island Waters, Papua, Indonesia
Authors: Sala Ridwan , Kusuma Aradea Bujana , Pranata Bayu 
Published: April 2023

Abstract. Sala R, Kusuma AB, Pranata B. 2022. Phylogenetic of red snapper (Lutjanidae) in Yapen Island Waters, Papua, Indonesia. Biodiversitas 23: 6428-6436. Red snappers are an economically valuable fishery resource. Most of these snapper species are inhabitants of coral reef ecosystems. A variety of red snapper species can be found in the northern waters of Papua, particularly in the Yapen Regency. However, information regarding the biological and ecological aspects of these fish is virtually unavailable. On the other hand, the utilization intensity of red snapper as a source of community income continues to increase. By using DNA barcode sequences, this study attempted to examine species diversity and relationships among Lutjanidae family species. The study was carried out from June to August 2022 in the waters of Yapen Regency by taking fish samples from the fish caught by local hand-lining fishers. Red snapper samples were identified morphologically and molecularly. According to molecular analyses, it was identified nine red snapper species from the genera of Lutjanus, Aphareus and Pristipomoides. The morphological characteristics of the species from the genus of Aphareus are similar to those from the genus of Pristipomoides yet different from those of the species from the genus of Lutjanus. The phylogenetic tree consisted of four clades with significant bootstrap values ranging from 98 to 99%. Clades 1, 2 and 3 comprise the species from the genus of Lutjanus, while clade 4 contains species from the genera of Aphareus and Pristipomoides. The greatest genetic distance was found between Lutjanus fulvus and Pristipomoides multidens, while the smallest genetic distance was found between Lutjanus vitta and Lutjanus ehrenbergii. Based on the study results, some management implications are discussed. For example, information on species biodiversity maps is needed to determine the target stock of a managed species so that management objectives are more focused on the species level and not on the genus or family level.
A Thread, Levitated and Hovering: The 4th Hangzhou Triennial of Fiber Art, Curated by Liu Tian
Authors: Zheng Ye 
Published: April 2023

Review of: A Thread, Levitated and Hovering: The 4th Hangzhou Triennial of Fiber Art, Curated by Liu Tian
Zhejiang Art Museum, Hangzhou, China, 18 October–4 December 2022 (main exhibition)
Hangzhou Museum, Hangzhou, China, 20 September–4 December 2022 (special programme Pure Reason)
Feminist Subjectivities in Fiber Art and Craft: Shadows of Affect, John Corso-Esquivel (2021)
Authors: Kettle Alice 
Published: April 2023

Review of: Feminist Subjectivities in Fiber Art and Craft: Shadows of Affect, John Corso-Esquivel (2021)
New York: Routledge, 182 pp.,
ISBN 978-0-36778-575-8, h/bk, £91.00
ISBN 978-0-36778-575-8, p/bk, £27.99
ISBN 978-1-35118-783-1, e-book, £27.99
Analysis of Consumer Preferences on Online Delivery Plastic Packaging Consumption Behavior: An Indonesian Survey
Authors: Hutagalung Ira Rumiris , Rachman Indriyani 
Published: April 2023

A heavy dependency on online shopping platforms and home delivery, together with emerging post-pandemic responses from developing nations like India, China, Brazil, and primarily Indonesia, sum up a surge in demand for unsustainable plastic packaging techniques. Consumer preference as the center of successful commercial strategy and become a consideration in waste management studies. This study aims to develop an understanding of consumer preference factors as a response to tackling the plastic problem due to the online delivery system in Indonesia. Google's web-based platform is used to capture the number of online deliveries in a weekly period. A five-level Likert scale measures attitudes, social norms, or perceptions toward a constructed questionnaire. From the ordinal regression analysis, younger people intend to consume more with online platforms, and the more people don't have a proper waste collection, the higher they will consume online plastic delivery.