bluuebunny/crossref_metadata_2025_split huggingface dataset:
High speed radiation tolerant optical links based on coarse wavelength division multiplexing
Authors: Marcon L. , Scarcella C. , Detraz S. , Lalović M. , Olantera L. , Prousalidi T. , Sandven U. , Sigaud C. , Soós C. , Troska J. 
Published: February 2023

Abstract
The upgrade of CERN’s accelerator complex requires improved beam instrumentation systems that will generate an increased volume of data to be transferred from the radiation areas to the back-end. A solution that increases the throughput of already deployed fibers, with minimal increase of the system complexity, consists in implementing the coarse wavelength division multiplexing (CWDM) technique where independent optical carriers at properly spaced wavelengths are multiplexed into a single fiber. In this paper we describe the CWDM Link project, whose scope is to design and build a high-speed radiation-tolerant optical link based on four CWDM channels. We will also provide details of commercially-available CWDM components and their radiation resistance.
Radiation hard true single-phase-clock logic for high-speed circuits in 28 nm CMOS
Authors: Klekotko A. , Baszczyk M. , Biereigel S. , Kulis S. , Moreira P. , Prinzie J. , Tavernier F. 
Published: February 2023

Abstract
True Single-Phase-Clock (TSPC) dynamic logic is widely used in high-speed circuits such as high-speed SERDES (Serializer/Deserializer) and frequency dividers. TSPC flip-flops (FF) are known for their high operational speed and low power consumption, compared to static FFs. Due to the relatively high leakage currents in modern CMOS processes, the use of leakage protection techniques of the storage nodes in TSPC must be considered, especially at high radiation doses. In this paper, the limitations originating from Total Ionization Dose (TID)-induced subthreshold leakage currents are analysed and radiation-hardening-by-design (RHBD) circuit techniques are proposed. Additionally, Single Event Upsets (SEU) are investigated by quantifying the critical charge of the leakage protected TSPC FF. The results are compared to both the static and the TSPC FF without leakage mitigation.
Reconsidering tympanal-acoustic interactions leads to an improved model of auditory acuity in a parasitoid fly
Authors: Mikel-Stites Max R , Salcedo Mary K , Socha John J , Marek Paul E , Staples Anne E 
Published: February 2023

Abstract
Although most binaural organisms locate sound sources using neurological structures to amplify the sounds they hear, some animals use mechanically coupled hearing organs instead. One of these animals, the parasitoid fly Ormia ochracea (O. ochracea), has astoundingly accurate sound localization abilities. It can locate objects in the azimuthal plane with a precision of 2°, equal to that of humans, despite an intertympanal distance of only 0.5 mm, which is less than

1

/

100

th of the wavelength of the sound emitted by the crickets that it parasitizes. O. ochracea accomplishes this feat via mechanically coupled tympana that interact with incoming acoustic pressure waves to amplify differences in the signals received at the two ears. In 1995, Miles et al developed a model of hearing mechanics in O. ochracea that represents the tympana as flat, front-facing prosternal membranes, though they lie on a convex surface at an angle from the flies’ frontal and transverse planes. The model works well for incoming sound angles less than

±

30

∘

but suffers from reduced accuracy (up to 60% error) at higher angles compared to response data acquired from O. ochracea specimens. Despite this limitation, it has been the basis for bio-inspired microphone designs for decades. Here, we present critical improvements to this classic hearing model based on information from three-dimensional reconstructions of O. ochracea’s tympanal organ. We identified the orientation of the tympana with respect to a frontal plane and the azimuthal angle segment between the tympana as morphological features essential to the flies’ auditory acuity, and hypothesized a differentiated mechanical response to incoming sound on the ipsi- and contralateral sides that depend on these features. We incorporated spatially-varying model coefficients representing this asymmetric response, making a new quasi-two-dimensional (q2D) model. The q2D model has high accuracy (average errors of under 10%) for all incoming sound angles. This improved biomechanical model may inform the design of new microscale directional microphones and other small-scale acoustic sensor systems.
Fluorescent carbon dots tailored iron oxide nano hybrid system for in vivo optical imaging of liver fibrosis
Authors: Nazeer Shaiju S , Saraswathy Ariya , Nimi Nirmala , Sarathkumar Elangovan , Resmi A N , Shenoy Sachin J , Jayasree Ramapurath S 
Published: February 2023

Abstract
Hybrid nanoparticles are innovative invention of last decade designed to overcome limitations of single-component nanoparticles by introducing multiple functionalities through combining two or more different nanoparticles. In this study, we are reporting development of magneto-fluorescent hybrid nanoparticles by combining iron oxide and carbon nanoparticles to enable in vivo fluorescence imaging which also has all the required characteristic properties to use as Magnetic Resonance Imaging (MRI) contrast agent. In order to achieve dual-functional imaging, alginate and pullulan coated super paramagnetic iron oxide nanoparticles (ASPION and PSPION) and Carbon dots (Cdts) were synthesised separately. ASPIONs and PSPIONs were further chemically conjugated with Cdts and developed dual-functional nanohybrid particles ASPION-Cdts and PSPION-Cdts. Subsequently, evaluation of the materials for its size, functionalisation efficiency, fluorescence and magnetic properties, biocompatibility and cellular uptake efficiency has been carried out. Fluorescence imaging of liver fibrosis was performed in vivo in rodent model of liver fibrosis using the two nanohybrids, which is further confirmed by high fluorescence signal from the harvested liver.
Mo2CTxMXene supported nickel-iron alloy: an efficient and stable heterostructure to boost oxygen evolution reaction
Authors: Loupias Lola , Boulé Roald , Morais Cláudia , Mauchamp Vincent , Guignard Nadia , Rousseau Julie , Pacaud Jérôme , Chartier Patrick , Gaudon Manuel , Coutanceau Christophe , Célérier Stéphane , Habrioux Aurélien 
Published: February 2023

AbstractA polyol-assisted solvothermal route is used to synthesize NixFeynanoalloys supported on a highly electron conductive 2D transition metal Mo2CTxMXene. Structural, morphological and chemical characteristics of the materials are determined using several physicochemical techniques. The MXene support allows not only the formation of a nanostructured metallic NixFeynanoalloys, but also favors the interfacial charge transfer for the oxygen evolution reaction (OER). The NixFey@Mo2CTxmaterial with a Ni/Fe ratio of 2.66 leads to the outstanding activity for the OER with an amazingly low Tafel slope value of 34 mV dec−1and a current density of 10 mA.cm−2at a potential of only 1.50 V vs. reversible hydrogen electrode (RHE).In situRaman experiments show thatβ-NiOOH formed by oxidation of the nanoalloys under positive scan, likely containing a very small amount of Fe, is the active phase for the OER. This material exhibits also an excellent stability over 168 h in a 5 M KOH electrolyte. Transmission electron microscopy -electron energy-loss spectroscopy analyses after 100 voltammetric cycles between 0.2 and 1.55 V vs. RHE evidence for the first time that the MXene support is not fully oxidized in the first cycle. Also, oxyhydroxide layer formed in the OER potential region at the surface of the NixFeynanoparticles can be reversibly reduced.
Intelligence and Executive Functions: A Comprehensive Assessment of Intellectually Gifted Children
Authors: Bucaille A , Jarry C , Allard J , Brosseau-Beauvir A , Ropars J , Brochard S , Peudenier S , Roy A 
Published: February 2023

AbstractObjectiveExecutive functions (EFs) play a key role in cognitive and behavioral functioning. Their multiple forms and implications for daily life behaviors mean they are sometimes equated with intelligence. Several elements even suggest that intellectually gifted children (IGC) may present better executive functioning than typical developing children (TDC, children with intelligence in the average range). However, no study has ever completely tested this hypothesis by a comprehensive assessment of EFs in IGC.MethodResults of 30 IGC and 35 TDC aged from 6 to 16 years old were compared through a comprehensive assessment of EFs (inhibition, flexibility, and planning), comprising performance-based and daily life measures.ResultsIGC did not differ from TDC in EF performance-based measures. However, they scored higher in parents’ and some teachers’ ratings, suggesting higher indicators of difficulties in daily life.ConclusionsContrary to expectations, high intellectual level does not appear to be associated with superior EFs. Surprisingly, parents and teachers of IGC reported more complaints about their executive functioning in everyday life. We put forward different hypotheses to explain this contrast. Further research is needed to better understand this phenomenon, in which neuropsychology has a fundamental role to play.
Olfactory Responses of Anastrepha obliqua (Diptera: Tephritidae) to Mango Fruits as Influenced by Cultivar and Ripeness Stages
Authors: Neri Benítez-Herrera Luz , Cruz-López Leopoldo C , Malo Edi A , Romero-López Angel A , Rojas Julio C 
Published: February 2023

Abstract
Anastrepha obliqua Macquart (Diptera: Tephritidae) is a polyphagous species with hog plums (Spondias spp.) (Sapindales: Anacardiaceae) and mangoes (Mangifera indica L.) (Sapindales: Anacardiaceae) as primary host fruits. In this study, the olfactory preference of A. obliqua for three stages of ripeness of two mango cultivars (‘Coche’ and ‘Ataulfo’) was investigated. The female flies were more attracted to ripe ‘Coche’ fruits compared to those ripe ‘Ataulfo’. Further, they were more attracted to the ‘Coche’ half-ripe and ripe fruits than to the unripe ones, but they did not discriminate among the stages of ripeness of ‘Ataulfo’ fruits. The male flies did not show preference for any specific mango cultivars or ripeness stage tested. Four compounds from ripe ‘Coche’ mangoes, and two from ripe ‘Ataulfo’ fruits were identified using coupled gas chromatography-electroantennographic (GC-EAD) recording and gas chromatography-mass spectrometry (GC-MS) analysis. ‘Coche’ mango volatiles eliciting responses from the female antennae were ethyl butyrate, ethyl hexanoate, ethyl heptanoate, and ethyl octanoate. The two ‘Ataulfo’ mango volatiles were identified as 3-carene and ethyl octanoate. These compounds were absent in unripe mangoes of both cultivars. Synthetic blends of these compounds were attractive to females as mango extracts in field cage tests. Our results suggest that the olfactory preference of A. obliqua for attractive hosts is based on the presence or absence of the compounds associated with fruit maturity.
Clinical Laboratory Approaches for Diagnoses of Sleep-Disordered Breathing and ADHD-Like Behavior in Children
Authors: Bratton Tiffany K , Jazayeri Maryam , Senthilvel Egambaram , Mendoza Maria Romelinda , Valdes Roland 
Published: February 2023

Abstract

Background
Impaired breathing during sleep, as in obstructive sleep apnea (OSA), can lead to behavior symptoms like those observed in children with attention deficit hyperactivity disorder (ADHD). Obstructive sleep apnea can be effectively treated, thus avoiding problematic pharmacotherapies associated with managing ADHD. Diagnosis of OSA relies on sleep studies as the gold standard, but in children, sleep studies are inherently difficult, cumbersome, and expensive and are not practical tools in the differential diagnosis of behavior disorders. Therefore, development of clinical laboratory tests for diagnoses of sleep apnea would change the standard of care for attention deficit syndromes.

Content
We review the status of potential laboratory tests for diagnosis of OSA in children with emphasis on markers linked to intermittent hypoxia and cardiovascular responses. In the context of ADHD, we focus on preliminary evidence and rationale for urocortin 3 and erythropoietin as urinary markers with physiologic relevance for diagnosis of OSA.

Summary
Laboratory tests that correlate with both OSA and ADHD-like syndromes would be useful to diagnose root causes of behaviors and identify a subset of children who may not need psychotropic medications. The discovery of laboratory biomarkers for OSA is evolving, but several candidates show promise and provide a segue to more focused development in laboratory diagnostics.
One-carbon metabolism and related pathways in ruminal and small intestinal epithelium of lactating dairy cows
Authors: Jiang Qianming , Sherlock Danielle N , Zhang Huimin , Guyader Jessie , Pan Yuan-Xiang , Loor Juan J 
Published: February 2023

AbstractPhysiological and environmental stresses such as the transition into lactation and heat load contribute to gastrointestinal tract (GIT) dysfunction. The nonruminant gastrointestinal tract has mechanisms to cope with pro-oxidant and pro-inflammatory stressors arising from the gut lumen or within intestinal cells. One-carbon metabolism (OCM) contributes to anti-oxidant capacity via the production of glutathione (GSH) and taurine, and the synthesis of phospholipid, creatine, and the osmolyte glycinebetaine among others. A multipronged approach was used to assess the biological relevance of OCM and closely-related pathways on GIT function in dairy cows. Ruminal papillae (Rum) and scrapings from duodenum (Duo), jejunum (Jej), and ileum (Ile) were collected at slaughter from eight multiparous Holstein cows averaging 128 ± 12 d in milk and producing 39 ± 5 kg/d. A MIXED model ANOVA with preplanned orthogonal contrasts was used for statistical analysis. Methionine adenosyl transferase 1 activity (MAT) was ~10-fold greater (P &lt; 0.01) and cystathionine β-synthase activity doubled in Rum vs. small intestine. Total glutathione peroxidase (GPX) activity was greatest (P = 0.03) in Ile, but similar to Rum. Activity and mRNA abundance of betaine-homocysteine S-methyltransferase were undetectable. There was a 2.5-fold greater protein abundance of GPX1 (P &lt; 0.01) and a ~2-fold greater abundance of GPX3 (P &lt; 0.01) in Rum vs. small intestine. Among the various amino acids (AA) with roles in OCM or closely-related pathways (e.g. creatine synthesis), concentrations of arginine, aspartate, glutamine, methionine, and serine were lower (P &lt; 0.01) in Rum vs. small intestine. Unlike AA, concentrations of OCM-related intermediates S-5ʹ-adenosyl-homocysteine (SAH), glycinebetaine, carnitine, creatine (CRE), and cysteinesulfinic acid were greater (P &lt; 0.01) while taurine was lower in Rum vs. small intestine. Intermediates of the folate cycle were undetectable. The fact that S-adenosylmethionine (SAM) was undetectable while MAT activity and SAH were greater in Rum suggested that availability of SAM (a methyl donor) is a key determinant of flux through the folate and methionine cycles in the GIT. Except for adenosine, concentrations of glutamate, glycine, α-ketoglutarate, hypotaurine, and GSH were lowest in Ile. Together, the data underscored unique differences in activity of one-carbon metabolism and related pathways across sections of the GIT.
High-flow nasal oxygen as an adjunct for the safe removal of impacted metallic upper airway foreign bodies
Authors: van den Berg Nadia , Aly Moustafa , Callaghan Michael , Keogh Ivan 
Published: February 2023

AbstractForeign body airway obstruction is considered an airway emergency and is a challenging clinical scenario for both the otolaryngologist and the anaesthetist. We present three cases of impacted upper airway metallic foreign bodies. Supra-glottic airways were obstructed and precarious. Apnoeic oxygenation utilizing high-flow nasal oxygen (HFNO), a form of tubeless anaesthetic, was used in all three cases, leading to the safe removal of the foreign bodies. Increased training, awareness and equipment availability to provide HFNO apnoeic oxygenation in the emergency setting for otolaryngology airway procedures will lead to better outcomes for patients and decreases the risk of a potential surgical airway.
Timing analysis of EXO 2030+375 during its 2021 giant outburst observed withInsight-HXMT
Authors: Fu Yu-Cong , Song L M , Ding G Q , Ge M Y , Tuo Y L , Zhang S , Zhang S N , Hou X , Qu J L , Zhang J , Zhang L , Bu Q C , Huang Y , Ma X , Zhou X , Yan W M , Yang Z X , Lu X F , Li T M , Xu Y C , Wang P J , Xiao S H , Liu H X , Ren X Q , Du Y F , Zhao Q X , Xiao Y X 
Published: February 2023

ABSTRACTWe report the evolution of the X-ray pulsations of EXO 2030+375 during its 2021 outburst using the observations from Insight-HXMT. Based on the accretion torque model, we study the correlation between the spin frequency derivatives and the luminosity. Pulsations can be detected in the energy band of 1–160 keV. The pulse profile evolves significantly with luminosity during the outburst, leading to that the whole outburst can be divided into several parts with different characteristics. The evolution of the pulse profile reveals the transition between the supercritical (fan-beam dominated) and the subcritical accretion (pencil-beam dominated) mode. From the accretion torque model and the critical luminosity model, based on a distance of 7.1 kpc, the inferred magnetic fields are (0.41 − 0.74) × 1012 and (3.48 − 3.96) × 1012 G, respectively, or based on a distance of 3.6 kpc, the estimated magnetic fields are (2.4 − 4.3) × 1013 and (0.98 − 1.11) × 1012 G, respectively. Two different sets of magnetic fields both support the presence of multipole magnetic fields of the neutron star.
Characterizing the nucleus of comet 162P/Siding Spring using ground-based photometry
Authors: Donaldson A , Kokotanekova R , Rożek A , Snodgrass C , Gardener D , Green S F , Masoumzadeh N , Robinson J 
Published: February 2023

ABSTRACT
Comet 162P/Siding Spring is a large Jupiter-family comet with extensive archival lightcurve data. We report new r-band nucleus light curves for this comet, acquired in 2018, 2021, and 2022. With the addition of these light curves, the phase angles, at which the nucleus has been observed, range from 0.39○ to 16.33○. We absolutely calibrate the comet light curves to r-band Pan-STARRS 1 magnitudes, and use these light curves to create a convex shape model of the nucleus by convex lightcurve inversion. The best-fitting shape model for 162P has axis ratios a/b = 1.56 and b/c = 2.33, sidereal period P = 32.864 ± 0.001 h, and a rotation pole oriented towards ecliptic longitude λE = 118○ ± 26○ and latitude βE = −50○ ± 21○. We constrain the possible nucleus elongation to lie within 1.4 &lt; a/b &lt; 2.0 and discuss tentative evidence that 162P may have a bilobed structure. Using the shape model to correct the light curves for rotational effects, we derive a linear phase function with slope β = 0.051 ± 0.002 mag deg−1 and intercept Hr(1, 1, 0) = 13.86 ± 0.02 for 162P. We find no evidence that the nucleus exhibited an opposition surge at phase angles down to 0.39°. The challenges associated with modelling the shapes of comet nuclei from light curves are highlighted, and we comment on the extent to which we anticipate that Legacy Survey of Space and Time will alleviate these challenges in the coming decade.
L’anxiété chez les enfants et les adolescents – partie 1 : le diagnostic
Authors: Klein Benjamin , Rajendram Rageen , Hrycko Sophia , Poynter Aven , Ortiz-Alvarez Oliva , Saunders Natasha , Andrews Debra 
Published: February 2023

RésuméLes troubles anxieux sont les problèmes de santé mentale les plus courants chez les enfants et les adolescents canadiens. La Société canadienne de pédiatrie a préparé deux documents de principes qui résument les données probantes à jour sur leur diagnostic et leur prise en charge. Ces documents contiennent des conseils fondés sur des données probantes afin d’aider les professionnels de la santé à prendre des décisions à l’égard des soins aux enfants et aux adolescents atteints de ces troubles. La première partie, qui porte sur l’évaluation et le diagnostic, vise à1) passer en revue l’épidémiologie et les caractéristiques cliniques des troubles anxieux; 2) décrire un processus d’évaluation des troubles anxieux. Des thèmes précis sont abordés, y compris la prévalence, le diagnostic différentiel, les affections concomitantes et le processus d’évaluation. Des démarches sont proposées pour standardiser le dépistage, recueillir l’anamnèse et observer le patient. Des caractéristiques et indicateurs connexes, qui distinguent les troubles anxieux des peurs, inquiétudes et sentiments d’anxiété adaptés au développement, sont examinés. Il est à souligner que, dans le présent document, le terme « parent » (au singulier ou au pluriel) inclut les personnes qui s’occupent principalement de l’enfant et toutes les configurations familiales.
Anxiety in children and youth: Part 2—The management of anxiety disorders
Authors: Bobbitt Susan , Kawamura Anne , Saunders Natasha , Monga Suneeta , Penner Melanie , Andrews Debra 
Published: February 2023

AbstractAnxiety disorders are the most common mental health concerns affecting Canadian children and adolescents. The Canadian Paediatric Society has developed two position statements that summarize current evidence regarding the diagnosis and management of anxiety disorders. Both statements offer evidence-informed guidance to support paediatric health care providers (HCPs) making decisions around the care of children and adolescents with these conditions. The objectives of Part 2, which focuses on management, are to: (1) review the evidence and context for a range of clinical approaches that combine behavioural and pharmacological interventions to effectively address impairment, (2) describe the roles of education and psychotherapy in the prevention and treatment of anxiety disorders, and (3) outline the use of pharmacotherapy, with side effects and risks. Recommendations for managing anxiety are based on current guidelines, review of the literature, and expert consensus. Note that when the word ‘parent’ (singular or plural) is used, it includes any primary caregiver and every configuration of family.
Arabidopsis ACT DOMAIN REPEAT9 represses glucose signaling pathways
Authors: Liao Hong-Sheng , Chen Ying-Jhu , Hsieh Wei-Yu , Li Yi-Chiou , Hsieh Ming-Hsiun 
Published: February 2023

Abstract
Nutrient sensing and signaling are critical for plants to coordinate growth and development in response to nutrient availability. Plant ACT DOMAIN REPEAT (ACR) proteins have been proposed to serve as nutrient sensors, but their functions remain largely unknown. Here, we showed that Arabidopsis (Arabidopsis thaliana) ACR9 might function as a repressor in glucose (Glc) signaling pathways. ACR9 was highly expressed in the leaves, and its expression was downregulated by sugars. Interestingly, the acr9-1 and acr9-2 T-DNA insertion mutants were hypersensitive to Glc during seedling growth, development, and anthocyanin accumulation. Nitrogen deficiency increased the mutants’ sensitivity to Glc. The expression of sugar-responsive genes was also significantly enhanced in the acr9 mutants. By contrast, the 35S:ACR9 and 35S:ACR9-GFP overexpression (OE) lines were insensitive to Glc during early seedling development. The Glc signaling pathway is known to interact with the plant hormone abscisic acid (ABA). Notably, the acr9 mutants were also hypersensitive to ABA during early seedling development. The Glc sensor HEXOKINASE1 (HXK1) and the energy sensor SUCROSE NON-FERMENTING1 (SNF1)-RELATED PROTEIN KINASE1 (SnRK1) are key components of the Glc signaling pathways. The acr9-1/hxk1-3 and acr9-1/snrk1 double mutants were no longer hypersensitive to Glc, indicating that functional HXK1 and SnRK1 were required for the acr9-1 mutant to be hypersensitive to Glc. Together, these results suggest that ACR9 is a repressor of the Glc signaling pathway, which may act independently or upstream of the HXK1-SnRK1 signaling module.