bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Keamanan Jaringan Komputer Terhadap Ancaman Phising pada Pengguna E-Commerce
Authors: Fitrian Harry Pribadi , Waryani Wida , Kirana Namia Resca 
Published: January 2025

Abstrak - Phishing merupakan teknik penipuan yang bertujuan untuk mendapatkan informasi sensitif, seperti kata sandi dan nomor kartu kredit, dengan menyamar sebagai entitas tepercaya. Meningkatnya ancaman phising terhadap e-commerce penting untuk melakukan analisis mendalam terhadap keamanan jaringan komputer dalam konteks e-commerce, guna mengidentifikasi dan mengurangi risiko yang ditimbulkan oleh serangan phishing. Tujuan penelitian ini untuk menganalisis dan memahami berbagai aspek keamanan jaringan komputer dalam konteks e-commerce, khususnya dalam pencegahan serangan phishing. Metode penelitian ini menggunakan deskriptif kualitatif dengan pendekatan literatur review untuk menganalisis keamanan jaringan komputer terhadap ancaman phising. Hasil penelitian menunjukkan bahwa analisis keamanan jaringan komputer sangat penting untuk melindungi pengguna e-commerce dari serangan phishing. Penelitian mengidentifikasi bahwa phising secara khusus menargetkan sektor sensitif e-commerce, dengan faktor-faktor seperti minimnya kesadaran pengguna dan kebijakan keamanan yang lemah berkontribusi terhadap keberhasilan serangan. Selain itu, edukasi pengguna dan penerapan langkah-langkah keamanan yang tepat dapat mengurangi risiko phising, sehingga kolaborasi antara penyedia layanan e-commerce dan pengguna sangat diperlukan untuk menciptakan lingkungan yang aman.Kata kunci: phising, e-commerce, ancaman dan keamanan jaringan Abstract - Phishing is a fraudulent technique that aims to obtain sensitive information, such as passwords and credit card numbers, by posing as a trusted entity. The increasing threat of phishing to e-commerce makes it important to conduct an in-depth analysis of computer network security in the context of e-commerce, in order to identify and reduce the risks posed by phishing attacks. The purpose of this research is to analyze and understand various aspects of computer network security in the context of e-commerce, especially in the prevention of phishing attacks. This research method uses descriptive qualitative with a literature review approach to analyze computer network security against phishing threats. The results showed that analyzing computer network security is very important to protect e-commerce users from phishing attacks. The research identified that phishing specifically targets the sensitive sector of e-commerce, with factors such as lack of user awareness and weak security policies contributing to the success of the attack. In addition, user education and the implementation of appropriate security measures can reduce the risk of phishing, so collaboration between e-commerce service providers and users is necessary to create a secure environment.Keywords: phishing, e-commerce, threat and network security
Educación y accesibilidad en museos: Explorando el potencial de la comunicación transmedia
Authors: Espinosa Barahona Haidy , Chacón Betancourt Maritza 
Published: January 2025

El presente ensayo aborda la confluencia entre educación, accesibilidad y comunicación transmedia en museos, destacando cómo las transformaciones digitales han facilitado la evolución de estas instituciones, de un modelo de comunicación unidireccional a uno más interactivo y participativo. Así también, aborda las barreras de accesibilidad que enfrentan las comunidades históricamente excluidas, como las personas sordas, al proponer a la museografía transmedia como herramienta para crear entornos más inclusivos que aseguren el acceso al conocimiento. Se propone un modelo de tres etapas que combina la interactividad digital, visitas presenciales y la cocreación de contenido, para impulsar un modelo de museo más accesible y participativo. El estudio concluye que la comunicación transmedia trasciende las barreras de la accesibilidad al promover experiencias dinámicas, inclusivas y participativas en condiciones de igualdad.
E-campañas: Uso de big data, inteligencia artificial en campañas políticas híbridas y la aparición de “wikiliderazgos”
Authors: Perugachi Kindler Ana E. 
Published: January 2025

Este artículo se vertebra de once momentos en los que se aborda la migración de las campañas políticas a la era digital. Primero se explica el uso de bots para ataques políticos en campaña; segundo, la automatización y minería de datos digitales para el diseño de dichas campañas; tercero, el uso de la big data y las redes sociales para la elaboración de bases de datos y la emisión de mensajes personalizados para los electores; cuarto, el uso de la big data y la inteligencia artificial (data science) para la segmentación del mercado de electores; quinto, el uso del metaverso en las campañas políticas híbridas y la aparición de “wikiliderazgos”, en escenarios inmersivos; sexto, la minería de datos y modelos metaanalíticos prospectivos; séptimo, el uso del deepfake para la creación de videos falsos en campaña; octavo, el caso Cambridge Analytica y la recaudación de fondos de campaña; noveno, la automatización de las campañas gracias a las plataformas virtuales; décimo, la creación de cuartos de guerra y el uso de trolls para ataques políticos; y undécimo, el metaverso, la ciberpolítica y el ciberactivismo. El marco analítico que rige esta investigación une la sociología política con la comunicación política digital. Las metodologías utilizadas fueron la “netnografía” y la observación participante. En tal sentido, este artículo pretende ser una hoja de ruta para académicos y analistas políticos.
Early childhood teachers’ understanding of executive functions and strategies employed to facilitate them
Authors: Madanipour Parian , Garvis Susanne , Cohrssen Caroline , Pendergast Donna 
Published: January 2025

IntroductionAdult-child interactions have a noteworthy influence over how executive functions develop. However, despite recognising the importance of executive functions in a child’s success, little research has been undertaken to explore the role of early childhood teachers in facilitating the development of executive functions in children through their teaching practice. The current study thus explored what understanding early childhood teachers have of executive functions and what pedagogical practices they use to contribute to the development of executive functions in 3 to 5-year-old children within preschool settings.MethodsData were collected through an online questionnaire completed by 58 early childhood teachers across Victoria, Australia. The questionnaire included both closed and open-ended questions, aiming to explore participants’ understanding of executive functions and the specific pedagogical practices they employed to facilitate the development of these skills in their classroom. Qualitative data from open-ended responses were analysed thematically to identify recurring practices and perceptions.ResultsThe results reveal that some early childhood teachers reported strong pedagogical understanding of executive functions. Further, they reported implementing practices in the everyday classroom intended to promote executive functions. Thematic analysis of qualitative data reveals that these early childhood teachers apply five pedagogical practices intended to facilitate executive functions: environment and activity structuring, supporting autonomous behaviours, enacting purposeful classroom organisation, encouraging sustained shared thinking, and conducting activities that support executive functions.DiscussionThe self-reported data in this study suggest that some early childhood teachers know much about evidence-based pedagogical practices that facilitate children’s executive functions. The reported pedagogical practices employed by such teachers aligned closely with practices recommended in the literature. However, participants’ pedagogical understanding was reported to have been gained through experience, drawing attention to the need for a stronger focus on executive functions during initial teacher education courses. As such, this study highlights the need for Australian early childhood initial teacher education courses to ensure that executive functions and executive functions-supportive pedagogical practices are explicitly addressed. The insights revealed here should inform initiatives that raise awareness and understanding of executive functions among early childhood teachers to forefront executive functions during their time spent with preschoolers.
Evaluation of de novo donor specific antibodies after kidney transplantation in the era of donor-derived cell-free DNA
Authors: Tian Yuan , Frischknecht Lukas , Mallone Anna , Rössler Fabian , Schachtner Thomas , Nilsson Jakob 
Published: January 2025

BackgroundDonor-derived cell-free DNA (dd-cfDNA) is a promising non-invasive biomarker for detecting graft injury in solid organ transplant recipients. Elevated dd-cfDNA levels are strongly associated with rejection and graft injury, especially antibody-mediated rejection (ABMR). While de novo donor-specific antibodies (dnDSA) are crucial in ABMR, the relationship between dd-cfDNA levels and dnDSA features, such as DSA category, MFI and HLA target loci, remains unclear.MethodsWe analyzed dd-cfDNA levels in 75 kidney transplant recipients who developed dnDSA post-transplant. dnDSA were categorized as “true”, “possible”, or “false” based on bead reactivity patterns and HLA typing. dd-cfDNA was assessed alongside dnDSA detection and sequential follow-up samples in a subgroup.Results“True” dnDSA showed significantly higher dd-cfDNA levels compared to “possible” and “false” groups. None of the dd-cfDNA values in the “false” group exceeded 0.6%, and only a small fraction of the “possible” group had values slightly above 0.6%. dd-cfDNA levels were not significantly affected by dnDSA target loci or number. A strong correlation between cumulative dnDSA MFI and dd-cfDNA levels was observed, especially in patients with “true” HLA-DQ-directed dnDSA. Sequential dd-cfDNA analysis showed dynamic changes in 25% of patients, all from the “true” dnDSA group, which tended to align with shifts in cumulative MFI over time.ConclusionThese findings highlight the correlation between cumulative dnDSA MFI and dd-cfDNA levels, particularly in HLA-DQ-directed dnDSA, and suggest graft injury is dynamic in dnDSA-positive patients. Integrated monitoring of dnDSA and dd-cfDNA offers a promising non-invasive approach for assessing graft injury and alloimmunity, potentially enhancing post-transplant care.
From ecological to anthropogenic factors: unraveling the drivers of blue crab Callinectes sapidus occurrence along the Mediterranean coasts
Authors: Gavioli Anna , Castaldelli Giuseppe , Eggleston David B. , Christian Robert R. 
Published: January 2025

IntroductionNon-native species are widely recognized as threats to biodiversity, ecosystems, and the services they provide to humans. The Mediterranean Sea has a high biodiversity of endemic species and is a hot spot of biological invasions. One of the most recent threats to Mediterranean ecosystems is the invasion of the Atlantic blue crab Callinectes sapidus.MethodsThe occurrences of the crab throughout the Mediterranean coastline were indexed from citizen science through the Global Biodiversity Information Facility. Using spatial analysis and linear mixed models, we investigated geomorphology (i.e., water depth and coastal wetlands extension), water physical variables (i.e., salinity and winter and summer water temperature), water quality variables (i.e., chlorophyll-a, nitrate and orthophosphate) and anthropogenic factors (i.e., ship density and population size) potentially affecting the blue crab occurrence along the coast.ResultsOur results showed that nitrate, as an indicator of riverine nutrient loading, and water depth, as an indicator of slope of the bottom, were the most influential variables in explaining the occurrences of blue crabs. Water temperature and salinity had lesser impacts; anthropogenic factors, such as the density of commercial marine traffic and human population size had no effect on blue crab occurrence.DiscussionThese results sug gest that benthic primary production and shallow water drive blue crab occurrences along the Mediterranean coasts. Even considering data limitations and gaps, our large-scale findings contribute to a broader understanding of the factors that drive blue crab invasion success which, in turn, can inform management actions and outline research needs.
Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab
Authors: Rossi Settimio , Gesualdo Carlo , Marano Ernesto , Perrotta Raffaele , Trotta Maria Consiglia , Del Giudice Antonio , Simonelli Francesca 
Published: January 2025

BackgroundAge-related macular degeneration (AMD) is a prevalent cause of irreversible vision loss worldwide, particularly among the elderly population. Two forms of late AMD are described: neovascular AMD (nAMD), characterized by abnormal choroidal blood vessel growth, and atrophic (dry) AMD, involving retinal cell degeneration. Intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents have transformed nAMD treatment, with Brolucizumab emerging as a promising therapy. The aim of this study is to provide the real-life anatomical-functional and safety results, after 1 year of treatment experience with Brolucizumab.MethodsThis is a retrospective observational real-life study in which 44 patients (44 eyes) diagnosed with nAMD and treated with Brolucizumab were enrolled. We identified two groups: group 1 (24 treatment-naïve eyes) that received a loading dose of 3 monthly intravitreal injections of Broluciziumab 6 mg (0.05 mL solution) + Q8w/Q12w regimen, and a Group 2 (20 non-naïve eyes) which performed 1 injection + ProReNata (PRN) scheme. Monthly, all participants underwent comprehensive ophthalmological evaluation until 12 months follow-up.ResultsWe observed a significant improvement in best corrected visual acuity (39 ± 15 L vs. 30 ± 17 L; p &lt; 0.01) and central retinal thickness (265 ± 89 μ vs. 360 ± 129 μ; p &lt; 0.0001) at the end of follow-up without any differences between treatment-naïve and non-naïve patients. These results were obtained with a low number of injections (3.7 ± 1.9) with only one case of intraocular drug-related adverse event. Finally, the presence of subretinal hyperreflective material correlates with lower visual recovery.DiscussionOur findings highlight the efficacy of Brolucizumab in managing wet-AMD and suggest its role for long-term efficacy in stabilizing retinal exudation and fluid accumulation, resulting in improved visual prognosis.
Analysis of physical activity levels and influencing factors in cancer survivors after pancreaticoduodenectomy
Authors: Tian Qiuju , Xue Meiqin , Chen Leying , Zhang Min , Zhu Weiyi , Wu Beiwen 
Published: January 2025

IntroductionPhysical activity is becoming more important in cancer patient care. However, there are limited studies investigating physical activity levels in cancer survivors after pancreaticoduodenectomy. This study aims to assess the present status of physical activity levels in cancer survivors after pancreaticoduodenectomy and whether perioperative metrics and length of follow-up have an impact on physical activity levels in survivorship.MethodsThis is a cross-sectional study. The study included cancer survivors who were treated at a tertiary general teaching hospital for pancreaticoduodenectomy from December 2019 to January 2022 following surgery. We quantified physical activity frequency, duration, and intensity using the International Physical Activity Questionnaire-Short Form. Patient demographic and clinical characteristics were obtained via an electronic medical record system. Postoperative complication data were obtained from our survival cohort. Variables univariately associated with the physical activity level at an alpha level of less than 0.1 were included in the logistic regression analysis of factors influencing physical activity in cancer survivors after pancreaticoduodenectomy.ResultsA total of 223 patients who met the eligibility criteria completed a telephone survey. The main form of physical exercise is walking, 69.5% of participants’ physical activity belongs to the active category, but only 16.6% of participants met the aerobic guideline. Logistic regression showed that cancer survivors without pancreatic fistula were 2.453 times more likely to perform active physical activity in survival than those with pancreatic leakage (p = 0.041). For a one-unit increase in operation duration, there is approximately a 0.5% reduction in the level of active physical activity participation among cancer survivors after pancreaticoduodenectomy (p = 0.015). For each unit increase in follow-up time, post-pancreaticoduodenectomy patients were 1.046 times more likely to participate in active physical activity (p = 0.030).ConclusionAlthough half of the cancer survivors after pancreaticoduodenectomy experienced active physical activity, only a small percentage of individuals met the guideline-recommended level of aerobic exercise. More physical activity support should be provided to cancer survivors after pancreaticoduodenectomy. Moreover, operation duration, postoperative pancreatic fistula, and follow-up time should be taken into consideration when giving exercise instructions to postoperative survivors of pancreaticoduodenectomy.
Pooled safety analysis of two phase 3 studies investigating trifluridine/tipiracil plus bevacizumab in patients with metastatic colorectal cancer
Authors: Taieb Julien , Fakih Marwan , Liposits Gabor , Prager Gerald W. , Van Cutsem Eric , Ciardiello Fortunato , Amellal Nadia , Calleja Elizabeth , Liu Mei , Roby Lucas , Tabernero Josep , André Thierry 
Published: January 2025

BackgroundTrifluridine/tipiracil (FTD/TPI) is approved as monotherapy and in combination with bevacizumab for the treatment of patients with refractory metastatic colorectal cancer (mCRC). FTD/TPI plus bevacizumab showed good tolerability in the phase 3 SOLSTICE (first-line) and SUNLIGHT (later-line) trials. This pooled analysis was performed to further characterize the safety of FTD/TPI plus bevacizumab and to compare safety in untreated and previously treated patients with mCRC.MethodsPatients must have received at least one dose of FTD/TPI plus bevacizumab in SOLSTICE (NCT03869892) or SUNLIGHT (NCT04737187). Treatment-emergent adverse events (TEAEs) in SOLSTICE and SUNLIGHT were graded per Common Terminology Criteria for Adverse Events versions 4.03 and 5.0, respectively. Times to onset/resolution of grade ≥3 hematologic TEAEs were assessed using Kaplan–Meier methodology. Treatment-related adverse events (TRAEs) were analyzed by age and Eastern Cooperative Oncology Group performance status (ECOG PS).ResultsThe pooled safety population comprised 669 patients (SOLSTICE, n = 423; and SUNLIGHT, n = 246). Grade ≥3 TEAEs were reported more frequently in SOLSTICE than in SUNLIGHT (86.8% vs. 72.4%), the most common being neutropenia and anemia. Overall, granulocyte colony-stimulating factor was used in 30.6% of patients. Median time to resolution of grade ≥3 hematologic adverse events/neutropenia to grade ≤2 was 8 days. Grade ≥3 TRAEs were more frequent in patients aged ≥75 years and those with an ECOG PS of 0 versus 1 or 2.ConclusionsFTD/TPI plus bevacizumab showed a consistent and manageable safety profile across first- and later-line mCRC treatment, including in vulnerable patients. Hematologic TEAEs were mostly reversible with appropriate management.
Impact of using time-averaged exposure metrics on binary endpoints in exposure-response analyses
Authors: Lin Yu-Wei , Largajolli Anna , Edwards A. Yin , Cheung S. Y. Amy , Patel Kashyap , Hennig Stefanie 
Published: January 2025

Exposure-response (ER) analyses are routinely performed as part of model-informed drug development to evaluate the risk-to-benefit ratio for dose selection, justification, and confirmation. For logistic regression analyses with binary endpoints, several exposure metrics are investigated, based on pharmacological plausibility, including time-averaged concentration to event (CavTE). CavTE is informative because it accounts for dose interruptions, modifications, and reductions and is therefore often compared against ER relationships identified using steady-state exposures. However, its derivation requires consideration in a logistic regression framework for time-invariant ER analysis because it has the potential to introduce bias. This study evaluated different approaches to derive CavTE for subjects whom did not have an event by the end of treatment (EoT) and assessed their impact on the ER relationship. Here we used a modified model based on a real data example for simulating exposures and events (safety) in different virtual population sizes (n = 50, 100, or 200) and drug effect magnitudes (0.5, 0.75, or 1). Events were generated using a proportional odds model with Markov components. For subjects whom did not experience an event, CavTE was derived at EoT, EoT+7 days, +14 days, +21 days, +28 days. The derivation of CavTE at different time points demonstrated significant impact on trends detected in logistic ER relationships that could bias subsequent event projection, dose selection and Go/No-Go decisions. CavTE in censored subjects must therefore be carefully derived to avoid potentially making false positive or negative conclusions. Overall, CavTE can be a useful exposure metrics in an ER analysis, when considered along with physiological or biological plausibility, the drug’s pharmacokinetic, and mechanism of action. Biological plausibility and different analysis factors (e.g., the time of the events with respect to observational period, the level of dose reduction/interruption) should be considered in the choice of the exposure metric. It is recognized that although time-invariant logistic regression is relatively fast and efficient, it overlooks recurring events and does not take into account the exposure and response time course with the potential drawback of ignoring important elements of the analysis like onset or duration of the effect. Care should be taken when ER relationships with other exposure metrics do not identify any statistically significant trends.