bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization and Characterization of Cellulose Extracted from Sugarcane Bagasse
Authors: Khalaf Eyad Sayed Abdallah 
Published: February 2023

Abstract
The surplus in the amount of agricultural wastes leftover on the Egyptian farmlands after each harvest season, along with the presidential initiative and the current strategic vision 2030 towards sustainable development, are the main challenge and strong ambition to conduct this research study. This study evaluates the extraction of sugarcane bagasse (SCB) celluloses with alkali treatment, aided by an optimization for the obtained results by using the response surface methodology (RSM) as a statistical method for modeling and analyzing a process. Seventeen experimental runs were executed to study the influence of various process variables, such as extraction time (1-4 hrs), temperature (50-90 oC) and the concentration of NaOH (2-10 %) on the response (yield) of extracted cellulose. It was estimated that the optimum operating conditions for extracting the high yield (0.5871 g of cellulose/g of bagasse) of cellulose were obtained at time of (2.4 hrs), temperature of (60 oC) and NaOH concentration of (9.8 %). It was also evident from these experiments that the suitable coefficient of determination (R2 = 0.8772), which is higher than 75 % showed that the quadratic polynomial model is significant and sufficient to represent the actual relationship between the response and significant variable. The extracted celluloses were characterized by Fourier transmission infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis. The increase in crystallinity from 31.76 percent for the raw bagasse fibres to 51.13 percent for the extracted cellulose, as observed from the XRD analysis was found to be in complete agreement with the findings of FTIR analysis.
Anesthetic Management of a Child with Adrenocortical Virilizing Tumour
Excision
Authors: Khatavkar Sonal , Suryawanshi Chhaya , Haroon Shahbaz , Patil Deepali 
Published: February 2023

Introduction:
A multidisciplinary team that includes an endocrinologist, radiologist, anesthesiologist, and surgeon is a prerequisite for adrenal gland surgeries. The prime indications for adrenal gland surgery can include both hormonal and non-hormonal secreting tumors. Adrenal hormone-secreting tumors usually present to the anesthesiologist with a unique set of challenges that require a good preoperative evaluation and hemodynamic control, corrections of all electrolytes and metabolic imbalances, a carefully planned anesthetic strategy, detailed knowledge about the specific diseases, maintaining of postoperative adrenal function, and finally a good collaboration with other involved colleagues. This review will mainly focus on endocrine issues and anesthetic management during the resection of a hormone-secreting adrenal gland tumor.

Case Presentation:
This is a case report of a 1.5-year-old boy weighing 13.5 kg who was admitted to our hospital with complaints of an increase in height and weight
more than appropriate for age, macroglossia, facial oedema, abnormally enlarged genitals and development of pubic hair for 6 months. On
examination along with signs of precocious puberty, he had presented raised blood pressure for which he was started on medication.

Results:
On ultrasonography, a 6*4 cm mass was seen in the right supra renal fossa which was confirmed on the CECT scan. He underwent surgery for the
excision of the tumor mass under general anesthesia with a regional blockade (epidural). The histopathological report of the tumor specimen
revealed Adrenocortical Carcinoma. The child required post-operative steroid treatment and subsequently was started on chemotherapy as well.

Conclusion:
The perioperative medical management of active Adreno Cortical Carcinomas is complex enough, but anesthesia causes even more substantial changes in physiology. Treatment with steroids helps to maintain hemodynamics to a great extent.
Assessment of Structural Basis for Thiazolopyridine Derivatives as DNA
Gyrase-B Inhibitors
Authors: Zambre Vishal Prakash , Petkar Nilesh Narayan , Dewoolkar Vishal Pravin , Bhadke Swapnali Vilas , Sawant Sanjay Dinkar 
Published: February 2023

Background:
Tuberculosis (TB) is one of the leading causes of death in the post-COVID-
19 era. It has been observed that there is a devastating condition with a 25-30% increase in TB patients.
DNA gyrase B isoform has proved its high potential to be a therapeutically effective target for
developing newer and safer anti-TB agents.

Objective:
This study aims to identify minimum structural requirements for the optimization of thiazolopyridine
derivatives having DNA gyrase inhibitory activities. Moreover, developed QSAR models
could be used to design new thiazolopyridine derivatives and predict their DNA gyrase B inhibitory
activity before synthesis.

Methods:
3D-QSAR and Group-based QSAR (G-QSAR) methodologies were adopted to develop accurate,
reliable, and predictive QSAR models. Statistical methods such as kNN-MFA SW-FB and
MLR SW-FB were used to correlate dependent parameters with descriptors. Both models were thoroughly
validated for internal and external predictive abilities.

Results:
The 3D-QSAR model significantly correlated steric and electrostatic descriptors with q2
0.7491 and predicted r2 0.7792. The G-QSAR model showed that parameters such as SsOHE-index,
slogP, ChiV5chain, and T_C_C_3 were crucial for optimizing thiazolopyridine derivatives as DNA
gyrase inhibitors. The 3D-QSAR model was interpreted extensively with respect to 3D field points,
and the pattern of fragmentation was studied in the G-QSAR model.

Conclusion:
The 3D-QSAR and G-QSAR models were found to be highly predictive. These models
could be useful for designing potent DNA gyrase B inhibitors before their synthesis.
The Effectiveness of an Integrated Symptom-related Fatigue Management
Program (ISFMP) on Pain, Anxiety, Fatigue Score and Lactate Levels in
Low-risk Pregnant Women During Childbirth
Authors: Chaisitsa-Nguan Kunnikar , Kongvattananon Puangpaka , Hawthorne Dawn 
Published: February 2023

Background:
Fatigue accumulates throughout the labor period and often occurs in conjunction with pain and anxiety during childbirth, resulting in negative effects on laboring women.

Objective:
The purpose of this study is to investigate the effectiveness of an integrated symptom-related fatigue management program (ISFMP) on pain, anxiety, fatigue score and lactate levels in a low-risk pregnant woman during childbirth.

Method:
This quasi-experimental study was conducted from August of 2021 to March of 2022 at Prachuap Khiri Khan Hospital. Sixty-five low-risk pregnant women with 32–41+6 weeks gestation were selected by the stratified random-sampling and matching techniques. They were then randomly assigned to either comparison or intervention groups. Data were collected using a demographic questionnaire and a visual analogue scale for pain, anxiety and fatigue. Lactate Pro 2 was used to evaluate lactate levels. Data were analyzed through statistical software (SPSS-26) using independent t-test, chi-square, repeated measure ANOVA and repeated measure multivariate analysis of variance (MANOVA). The significance level was set at p <.05.

Results:
The participants in the comparison and experimental groups had varying pain, anxiety, fatigue
scores and lactate levels throughout their progression of labor. Pain, anxiety and fatigue in the
experimental group were significantly lower than in the comparison group (p < .001). There were no
statistically significant differences in lactate levels between the two groups.

Conclusion:
The ISFMP was shown to be effective in lowering the symptoms of pain, anxiety and fatigue in women in labor. Midwives should apply the ISFMP in their clinical practice when caring for low-risk pregnant women.
Clinical Features of Extragenital Scar Endometriosis: A Cross-Sectional
Study
Authors: Ferro Beatriz , Gama João Martins , Cordeiro Mariana Robalo , Figueiredo-Dias Margarida 
Published: February 2023

Objective:
Abdominal wall endometriosis (AWE) is a rare form of extragenital endometriosis
that usually develops in association with a prior surgical scar. The purpose of the study was to review
the clinical characteristics, diagnostic methods, treatment modalities, and outcomes of patients
with AWE.

Methods:
A descriptive cross-sectional study was performed in a Gynecology Department of a Portuguese
tertiary hospital, concerning patients with histologic-proven AWE, between January 2012 and
December 2020 (n = 22). Statistical analysis was performed using IBM SPSS Statistics Version 27.00,
with a significance level of p < 0.05.

Results:
The most common locations of extrapelvic endometrial ectopic implants were cesarean delivery
scar (n = 13, 59.1%) and the umbilicus (n = 5, 22.7%). The median (range) age was 36 (30-42)
years old, and all patients had a history of previous surgery but one. Nineteen patients had undergone
a previous cesarean section, and the mean (range) time from surgery to the onset of symptoms was
100 (32-168) months. All patients were symptomatic and presented with a palpable mass at physical
examination. The majority complained of a painful abdominal mass (n = 20, 90.9%) which was associated
with cyclic pain in thirteen patients (65%). Ultrasound scan was performed in all patients and
the nodules had a median size of 20.5 mm (5-93 mm). One patient received hormonal therapy and
surgical resection was performed in the remaining patients. The nodule’s median (range) size was 31
(12-50) mm on gross examination.

Conclusion:
AWE should be considered in the presence of a previous pelvic surgery history associated
with abdominal scar cyclic pain and swelling. A careful history and clinical examination are essential
for diagnosis to avoid unnecessary delay before surgical intervention.
Stem Cell Therapy for the Treatment of Parkinson's Disease: What Promise
Does it Hold?
Authors: Nasrolahi Ava , Shabani Zahra , Sadigh-Eteghad Saeed , Salehi-Pourmehr Hanieh , Mahmoudi Javad 
Published: February 2023

Abstract:
Parkinson's disease (PD) is a common, progressive neurodegenerative disorder characterized
by substantia nigra dopamine cell death and a varied clinical picture that affects older people. Although
more than two centuries have passed since the earliest attempts to find a cure for PD, it remains an unresolved
problem. With this in mind, cell replacement therapy is a new strategy for treating PD. This novel
approach aims to replace degenerated dopaminergic (DAergic) neurons with new ones or provide a new
source of cells that can differentiate into DAergic neurons. Induced pluripotent stem cells (iPSCs), mesenchymal
stem cells (MSCs), neural stem cells (NSCs), and embryonic stem cells (ESCs) are among the
cells considered for transplantation therapies. Recently disease-modifying strategies like cell replacement
therapies combined with other therapeutic approaches, such as utilizing natural compounds or biomaterials,
are proposed to modify the underlying neurodegeneration. In the present review, we discuss the current
advances in cell replacement therapy for PD and summarize the existing experimental and clinical
evidence supporting this approach.
DEGoldS: A Workflow to Assess the Accuracy of Differential Expression
Analysis Pipelines through Gold-standard Construction
Authors: Hurtado Mikel , Mora-Márquez Fernando , Soto Álvaro , Marino Daniel , Goicoechea Pablo G. , de Heredia Unai López 
Published: February 2023

Background:
Non-model species lacking public genomic resources have an extra handicap in
bioinformatics that could be assisted by parameter tuning and the use of alternative software. Indeed, for
RNA-seq-based gene differential expression analysis, parameter tuning could have a strong impact on
the final results that should be evaluated. However, the lack of gold-standard datasets with known expression
patterns hampers robust evaluation of pipelines and parameter combinations.

Objective:
The aim of the presented workflow is to assess the best differential expression analysis pipeline
among several alternatives, in terms of accuracy. To achieve this objective, an automatic procedure
of gold-standard construction for simulation-based benchmarking is implemented.

Methods:
The workflow, which is divided into four steps, simulates read libraries with known expression
values to enable the construction of gold-standards for benchmarking pipelines in terms of true and
false positives. We validated the workflow with a case study consisting of real RNA-seq libraries of radiata
pine, a forest tree species with no publicly available reference genome.

Results:
The workflow is available as a freeware application (DEGoldS) consisting on sequential Bash
and R scripts that can run in any UNIX OS platform. The presented workflow proved to be able to construct
a valid gold-standard from real count data. Additionally, benchmarking showed that slight pipeline
modifications produced remarkable differences in the outcome of differential expression analysis.

Conclusion:
The presented workflow solves the issues associated with robust gold-standard construction
for benchmarking in differential expression experiments and can accommodate with a wide range
of pipelines and parameter combinations.
Papillary Thyroid Carcinoma: A Narrative Review on the Most Important
Genetic and Epigenetic Alterations
Authors: Mohammadi Atiyeh , Ahmadi Seyyed Amir Yasin , Nekouian Reza 
Published: February 2023

Abstract:
Papillary Thyroid Carcinoma (PTC) is the most common subtype of thyroid cancer
that is the most prevalent one in the endocrine system. According to worldwide reports,
its prevalence rate has been increasing in recent decades. The Discovery of DNA sequencing
methods and molecular diagnostic techniques provides an insight into the understanding
of PTC molecular biology and as well as in thyroidology, which opens a new perspective in
finding molecular markers. Aligning cytological diagnostic methods with molecular behavior
studies creates promising tools for better decision-making strategies for preoperative
conditions to distinguish between benign from malignant thyroid nodules in challenging
cases and limit unnecessary surgeries. Extensive studies have been performed on identifying
the genes involved in PTC development and their prognosis. Currently, clinical and pathological
features of the tumour (such as size, extrathyroid and lymph node invasion, and capsular
invasion) are used to predict the prognosis of papillary thyroid cancer. In this review,
we tried to summarize fundamental signaling pathways affecting PTC and the most important
genetic alterations, including point mutations in proto-oncogenes and chromosomal
rearrangements, as well as up/down-regulation of certain micro RNAs (miRNA) as an epigenetic
change. Briefly, some of the most commonly altered genes in PTC are BRAF, RAS,
RET, PAX8, PPARγ, and miRNAs like mir-146b, mir-221, mir-222, and mir-181b.
Effect of Teleyoga Before COVID-19 and During Pandemic: A
Narrative Review
Authors: Ruchi Dua , Saloni Malik , Ramesh Kumar , Indrajeet Sharma , Sunil Kumar , Anissa Mirza Atif , Girish Sindhwani 
Published: February 2023

Background:
Yoga plays a beneficial adjunctive role in various disorders due
to its physiological and psychological benefits. COVID-19 pandemic led to a paradigm
shift in delivery of health interventions from on-site to online/ tele-intervention mode.
Focus shifted to tele-yoga as a reasonable and feasible alternative to in-person yoga. Studies
have evaluated its effect among patients suffering from various disorders, their care
givers, healthcare workers, and the general public. We have assessed the effect of tele-
Yoga, including its appropriateness, acceptability, and benefits, via this narrative review.

Methods:
We searched PubMed data base using predefined keywords. Inclusion criteria
included controlled trials and Randomized Controlled Trials (RCTs) which are completed
and published in English language up to February 2022 with tele-yoga/online yoga as
part of intervention. Exclusion criteria included articles in other language or articles
whose full text is unavailable.

Results:
After removing duplications and reviewing articles based on title, abstracts,
and available full texts, seven studies with 391 participants were included. Majority of
the trials took place in United States, with United Kingdom, Canada, and India following
closely behind. Yoga can be safely administered via various online /tele
interventions in both diseased and healthy individuls. Tele yoga or modules
incorporating tele-yoga has been shown to improve symptoms like dyspnea,
psychiatric/psychological burden including stress,anxiety and depression levels and may
promote positive effects like spirituality.

Conclusion:
Tele-yoga is feasible and beneficial in healthy and diseased individuals.
Larger well-designed RCTs comparing in-person yoga with tele-yoga are needed to ascertain
their full benefits.
Polijas–Lietuvas (Žečpospoļitas) Inflantijas vojevodistes (1677–1772) nodokļu un ienākumu jautājums
Authors: Seliška Edvards 
Published: February 2023

Raksta mērķis ir, balstoties uz pieejamajiem publicētiem un nepublicētiem materiāliem, izsekot nodokļu politikas attīstībai un tās efektivitātei Inflantijā. Šis jautājums ir cieši saistīts ar vietējās muižniecības jeb šļahtas reālajiem ienākumiem un vojevodistes potenciālu kopumā. Šļahta faktiski kontrolēja, cik lieli nodokļi tai jāmaksā, tādējādi slēpjot īstos ienākumus. Tomēr pēc Staņislava Augusta kāpšanas Žečpospoļitas tronī 1764. gadā notika finanšu reformas, un šajā procesā piedalījās arī vietējie Inflantijas šļahtas pārstāvji, tā nodrošinot patiesāku informāciju par Inflantijas potenciālu. Līdz ar Polijas pirmo dalīšanu (1772. gadā) jaunā Krievijas vara veica īpašumu lustrāciju, sniedzot visprecīzāko priekšstatu par 18. gadsimta Inflantiju un norādot, ka, iespējams, tā ir bijusi turīgāka, nekā uzrādīja maksājamie nodokļi. No vienas puses, Inflantija 18. gadsimtā bija militāri neaizsargāta, gadsimta sākumā cietusi karos, no otras puses, tā bija demogrāfiski plaukstoša province ar nelielu šļahtas slāni, kur preču tranzīts, kroģēšana un zemes iznomāšana bija nozīmīgs ienākumu avots.
A Comparison of the Motor Skills of Young People in a Youth Detention Centre with Diagnosed Fetal Alcohol Spectrum Disorder, Prenatal Alcohol Exposure, and a Reference Population
Authors: Safe Bernadette , Joosten Annette , Bower Carol , Condon Carmen , Watkins Rochelle , Mutch Raewyn , Giglia Roslyn 
Published: February 2023

Materials and Methods: Participants completed the Movement Assessment Battery for Children-2 (MABC-2), Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI) including its associated subtests, and a handwriting screen.
Results: Ninety-nine young people (n=47 PAE; n= 36 FASD) with a mean age of 16 years were assessed. There was an association between a FASD diagnosis and lower scores on the VMI (p=0.005). Participants with FASD and PAE had higher impairment levels on the VMI compared to the No-PAE group. Mean MABC-2 scores were within age expected levels across all groups. More fine motor skill difficulties were observed compared to gross motor skill difficulties. Handwriting skills were below age expected levels in 84% of participants. Those in the PAE and FASD groups had more difficulty with letter formations and spatial awareness.
Conclusions: Visual motor integration and handwriting skills were often impaired in this population. Lower VMI scores were more prevalent in participants diagnosed with FASD, and therefore should be routinely assessed as part of a diagnostic assessment. Assessment of fine and gross motor skills enabled recommendations for intervention support that address deficits and build upon strengths. Further research is needed to confirm these results using larger populations, and to investigate possible confounding factors associated with high VMI and handwriting difficulties in this population.
TERHADAP SANKSI DALAM PERATURAN WALIKOTA DITINJAU DARI UNDANG-UNDANG PEMBENTUKAN PERATURAN PERUNDANG-UNDANGAN
Authors: Tumangger Elfi Nola , Amir Latifah , Dewi Ratna 
Published: February 2023

Penelitian ini bertujuan untuk menganalisis kepastian hukum terhadap Sanksi Denda Dalam Peraturan Walikota Jambi Nomor 21 Tahun 2020 Ditinjau Dari Undang-Undang Nomor 12 Tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan. Rumusan masalah bagaimana substansi peraturan Walikota Jambi Nomor 21 Tahun 2020 memuat Sanksi administrasi Ditinjau Dari Undang-Undang Nomor 12 Tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan? Apakah Peraturan Walikota Jambi Nomor 21 Tahun 2020 Dapat Memuat Denda Administratif Ditinjau Dari Undang-Undang Nomor 12 Tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan. Hasil dari penelitian ini yaitu produk hukum yang dianggap bertentangan dengan yang lebih tinggi menjadi batal demi hukum atau adanya ketidakpastian hukum dikarenakan dalam Undang-Undang Nomor 12 Tahun 2011 tentang peraturan perundang-undangan sebagaimana yang dimaksud pasal 15 ayat (1) mencantumkan bahwa ketentuan sanksi hanya dapat dimuat dalam Undang-undang; Peraturan Daerah Provinsi, dan Peraturan Daerah Kabupaten/Kota. Disisi lain, Peraturan Walikota Nomor 21 Tahun 2020 mencatumkan adanya ketentuan sanksi adminitratif, berdasarkan pembentukan peraturan perundang-undangan. Peraturan tersebut dianggap bertentangan dengan ketentuan yang lebih tinggi dan sanksi adminitratif menitikberatkan kepada badan/pejabat tata usaha negara yang secara hukum melanggar kewenangan di dalam menyelenggarakan sistem pemerintahan, oleh sebab itu peraturan Walikota Jambi secara hukum dianggap batal demi hukum dan ketidaksahaannya pengaturan sanksi tersebut diatur dalam peraturan kebijakan daerah di masa pandemi saat ini berdasarkan Undang-Undang Nomor 12 Tahun 2011 tentang peraturan perundang-undangan.
Indicadores de cuidado de enfermería hospitalario orientados por modelo de práctica profesional
Authors: Sánchez Herrera Beatriz 
Published: February 2023

Objetivo Diseñar y validar indicadores de cuidado de enfermería a partir de la orientación de un modelo de práctica profesional en un hospital universitario de Colombia, 2018 – 2021. Material y Método: Esta es una “Investigación metodológica en enfermería” desarrollada por fases: 1) revisión de los procesos de calidad institucional. 2) revisión de literatura sobre indicadores hospitalarios de enfermería. 3) propuesta de indicadores con orientación del modelo institucional de práctica profesional de enfermería 4) validación de los indicadores mediante criterio de expertos y 5) evaluación de la efectividad preliminar en campo durante 8 meses. Resultados: Los 21 indicadores de cuidado de enfermería propuestos presentaron alta comprensibilidad y validez facial, una razón de validez de contenido (RVC) entre .74 y .96, y un índice de validez de contenido (IVC) de 0.83. Conclusión: Los indicadores de cuidado de enfermería diseñados bajo la orientación de un modelo de práctica profesional y validados mediante el criterio de expertos, mostraron una efectividad preliminar positiva para medir y mejorar los procesos y resultado del cuidado de enfermería de acuerdo con las personas implicadas en la recepción y suministro de dicho cuidado. Estos indicadores pueden ser empleados en hospitales con plataformas estratégicas similares.