bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical Education for Health Among School-Aged Children and Adolescents: A Scoping Review of Reviews
Authors: Ramires Virgílio Viana , dos Santos Priscila Cristina , Barbosa Filho Valter Cordeiro , Bandeira Alexsandra da Silva , Marinho Tenório Maria Cecilia , de Camargo Edina Maria , Ravagnani Fabrício Cesar de Paula , Sandreschi Paula , de Oliveira Victor José Machado , Hallal Pedro Curi , Silva Kelly Samara 
Published: May 2023

Background: Physical education (PE) classes in schools are considered relevant to implement interventions, especially focused on physical activity. However, evidence overviews on how PE classes contribute to general health (physical, social, affective, and cognitive domains) are still needed. Thus, we summarized evidence synthesis (eg, systematic reviews) that addressed the contribution of PE classes to the health of school-aged children and adolescents. Methods: We performed a scoping review with searches in 8 databases and institutional websites to find systematic reviews or meta-analyses that answered this review’s research question. Data charting form included the identification of the study, health outcomes, and PE classes’ strategies (policies and environment, curriculum, appropriate instructions, and evaluation). An interactive process was performed to build the evidence summary. Results: An initial search yielded 2264 titles, and 49 systematic reviews (including 11 with meta-analysis) were included in this review. Most documents reported the main benefits of PE classes on physical domain outcomes (eg, physical activity, cardiorespiratory fitness, body mass index, and fundamental motor skills). However, evidence on the benefits of PE classes in affective (eg, enjoyment, motivation, and autonomy); social (eg, cooperation, problem-solving, and making friends); and cognitive (eg, memory, attention, concentration, and decision making) domains were found. Strategies on PE classes for health benefits were highlighted. Conclusions: These elements were detailed in the evidence summary, which may be considered to guide researchers, teachers, and practitioners to define research and practice priorities on PE class interventions for health in the school context.
The source of tungsten-associated magmas in the northern Canadian Cordillera and implications for the basement
Authors: Rasmussen Kirsten L. , Falck Hendrik , Elongo Vanessa , Reimink Jesse , Luo Yan , Pearson D. Graham , Ootes Luke , Creaser Robert A. , Lecumberri-Sanchez Pilar 
Published: May 2023

Abstract
The crustally derived Tungsten Plutonic Suite (TPS) in the northern Canadian Cordillera is responsible for several of the world’s most important tungsten (W) resources, but the actual source rocks to these exceptionally metallogenic magmas have never been identified. Detrital zircon studies have improved our knowledge of exposed supracrustal packages in the region, such that a U-Pb study of inherited zircon cores in the TPS provides an opportunity to determine the age and provenance of the melt source to these magmas. The TPS is dominated by Neoarchean to Paleoproterozoic inherited zircons that are typical of a northwest Laurentian “cratonic” detrital zircon signature (e.g., 2.8–1.8 Ga). Cross-correlation statistical analysis of detrital zircon populations combined with whole-rock neodymium isotopic compositions indicate that mid- to late Cambrian sedimentary rocks in the Selwyn Basin are the most likely melt source for the TPS magmas. Despite the presence of prospective intrusions across the Selwyn Basin, world-class W metallogeny is limited to the narrow belt of TPS plutons in the eastern Selwyn Basin near the ancient continental margin, possibly due to depositional or structural controls on the source strata. Today, the early Phanerozoic melt source to the TPS must be present at depths of at least 15–17 km and is notably younger than suggested by current geophysical interpretations for the middle crust, requiring a reconsideration of the crustal architecture in the northern Canadian Cordillera.
Supplemental Material: Challenger Deep basalts reveal Indian-type Early Cretaceous oceanic crust subducting in the southernmost Mariana Trench
Authors: Xu Wenjing , Peng Xiaotong , al. et 
Published: May 2023

<p>Supplemental Figures S1–S6 and Tables S1–S4, and extended information about samples, methods, and results. </p>
Decisional needs assessment for patient-centred pain care in Canada: the DECIDE-PAIN study protocol
Authors: Naye Florian , Légaré France , Paquette Jean-Sébastien , Tousignant-Laflamme Yannick , LeBlanc Annie , Gaboury Isabelle , Poitras Marie-Eve , Toupin-April Karine , Li Linda C , Hoens Alison , Poirier Marie-Dominique , Décary Simon 
Published: May 2023

IntroductionThe 2021 Action Plan for Pain from the Canadian Pain Task Force advocates for patient-centred pain care at all levels of healthcare across provinces. Shared decision-making is the crux of patient-centred care. Implementing the action plan will require innovative shared decision-making interventions, specifically following the disruption of chronic pain care during the COVID-19 pandemic. The first step in this endeavour is to assess current decisional needs (ie, decisions most important to them) of Canadians with chronic pain across their care pathways.Methods and analysisDesignGrounded in patient-oriented research approaches, we will perform an online population-based survey across the ten Canadian provinces. We will report methods and data following the CROSS reporting guidelines.SamplingThe Léger Marketing company will administer the online population-based survey to its representative panel of 500 000 Canadians to recruit 1646 adults (age ≥18 years old) with chronic pain according to the definition by the International Association for the Study of Pain (eg, pain ≥12 weeks).ContentBased on the Ottawa Decision Support Framework, the self-administered survey has been codesigned with patients and contain six core domains: (1) healthcare services, consultation and postpandemic needs, (2) difficult decisions experienced, (3) decisional conflict, (4) decisional regret, (5) decisional needs and (6) sociodemographic characteristics. We will use several strategies such as random sampling to improve survey quality.AnalysisWe will perform descriptive statistical analysis. We will identify factors associated with clinically significant decisional conflict and decision regret using multivariate analyses.Ethics and disseminationEthics was approved by the Research Ethics Board at the Research Centre of the Centre Hospitalier Universitaire de Sherbrooke (project #2022-4645). We will codesign knowledge mobilisation products with research patient partners (eg, graphical summaries and videos). Results will be disseminated via peer-reviewed journals and national and international conferences to inform the development of innovative shared decision-making interventions for Canadians with chronic pain.
Serum folate deficiency and associated factors among pregnant women in Haramaya District, Eastern Ethiopia: a community-based study
Authors: Mamme Newas Yusuf , Roba Hirbo Shore , Fite Meseret Belete , Asefa Gemechu , Abrahim Jemal , Yuya Mohammed , Wilfong Tara , Gurmu Demiraw Bikila , Waka Feyissa Challa , Tessema Masresha , Habtu Wossene , Woldeyohannes Meseret , Raru Temam Beshir , Kure Mohammed Abdurke , Alemayehu Dawit , Motuma Aboma , Roba Kedir Teji 
Published: May 2023

ObjectivesWe aimed to estimate the prevalence of folate deficiency and contributing factors among pregnant women.DesignA community-based, cross-sectional study.SettingHaramaya District, Eastern Ethiopia.ParticipantsFour hundred and forty-six pregnant women participated in the study.Primary outcome measureThe prevalence of folate deficiency and risk factors.ResultsOverall, the prevalence of folate deficiency was 49.3% (95% CI 44.6% to 54.1%). Pregnant women with iron deficiency anaemia were 2.94 times more likely to develop folate deficiency (adjusted OR (AOR)=2.9, 95% CI 1.9 to 4.7). Respondents with good knowledge of folate-rich foods (AOR=0.3, 95% CI 0.1 to 0.7) and those who took iron and folic acid supplementation (AOR=0.6, 95% CI 0.4 to 0.9) during their pregnancy were less likely to develop folate deficiency.ConclusionsIn this study, a considerable proportion of pregnant women had folate deficiency during their pregnancy. Therefore, it is critical that nutritional treatment, education and counselling be strengthened to facilitate iron and folic acid supplementation during pregnancy.
Risk factors and protective factors of acute postoperative pain: an observational study at a German university hospital with cross-sectional and longitudinal inpatient data
Authors: Riecke Jenny , Zerth Simon Felix , Schubert Ann-Kristin , Wiesmann Thomas , Dinges Hanns-Christian , Wulf Hinnerk , Volberg Christian 
Published: May 2023

ObjectivesSurgical fear is one of the most important psychological risk factors for postoperative pain, but less is known about the contribution of protective factors. This study investigated somatic and psychological risk and resilience factors of postoperative pain and validated the German version of the Surgical Fear Questionnaire (SFQ).SettingUniversity Hospital of Marburg, Germany.DesignSingle-centre observational study and cross-sectional validation study.ParticipantsData for validating the SFQ were obtained from a cross-sectional observational study (N=198, mean age 43.6 years, 58.8% female) with persons undergoing different kinds of elective surgery. A sample of N=196 (mean age 43.0 years, 45.4% female) undergoing elective (orthopaedic) surgery was analysed to investigate somatic and psychological predictors of relevant acute postsurgical pain (APSP).Outcome measuresParticipants completed preoperative and postoperative assessments at postoperative days 1, 2 and 7. Presurgical pain, age, gender, pain expectation, surgical setting, physical status, anaesthesia, surgical fear, pain catastrophising, depression, optimism and self-efficacy were examined as predictors.ResultsConfirmatory factor analysis confirmed the original two-factor structure of the SFQ. Correlation analyses indicated good convergent and divergent validity. Internal consistency (Cronbach’s α) was between 0.85 and 0.89. Blockwise logistic regression analyses for the risk of APSP revealed outpatient setting, higher preoperative pain, younger age, more surgical fear and low dispositional optimism as significant predictors.ConclusionsThe German SFQ is a valid, reliable and economical instrument with which the important psychological predictor surgical fear can be assessed. Modifiable factors that increase the risk of postoperative pain were higher pain intensity before surgery and being fearful about negative consequences of the surgery whereas positive expectations seem to buffer against postsurgical pain.Trial registration numbersDRKS00021764 and DRKS00021766.
Intervention development of ‘Diabetes Together’ using the person-based approach: a couples-focused intervention to support self-management of type 2 diabetes in South Africa
Authors: Smith Kirsten Ailsa , Van Pinxteren Myrna , Mbokazi Nonzuzo , Majikela-Dlangamandla Buyelwa , Delobelle Peter , Levitt Naomi , McGrath Nuala 
Published: May 2023

ObjectivesType 2 diabetes (T2D) is a growing concern in South Africa, where many find self-management challenging. Behaviour-change health interventions are enhanced by involving partners of patients. We aimed to develop a couples-focused intervention to improve self-management of T2D among adults in South Africa.DesignWe used the person-based approach (PBA): synthesising evidence from existing interventions; background research; theory; and primary qualitative interviews with 10 couples to ascertain barriers and facilitators to self-management. This evidence was used to formulate guiding principles that directed the intervention design. We then prototyped the intervention workshop material, shared it with our public and patient involvement group and ran iterative co-discovery think-aloud sessions with nine couples. Feedback was rapidly analysed and changes formulated to improve the intervention, optimising its acceptability and maximising its potential efficacy.SettingWe recruited couples using public-sector health services in the area of Cape Town, South Africa, during 2020–2021.ParticipantsThe 38 participants were couples where one person had T2D.InterventionWe developed the ‘Diabetes Together’ intervention to support self-management of T2D among couples in South Africa, focussing on: improved communication and shared appraisal of T2D; identifying opportunities for better self-management; and support from partners. Diabetes Together combined eight informational and two skills-building sections over two workshops.ResultsOur guiding principles included: providing equal information on T2D to partners; improving couples’ communication; shared goal-setting; discussion of diabetes fears; discussing couples’ roles in diabetes self-management; and supporting couples’ autonomy to identify and prioritise diabetes self-management strategies.Participants viewing Diabetes Together valued the couples-focus of the intervention, especially communication. Feedback resulted in several improvements throughout the intervention, for example, addressing health concerns and tailoring to the setting.ConclusionsUsing the PBA, our intervention was developed and tailored to our target audience. Our next step is to pilot the workshops’ feasibility and acceptability.
Citizen Science to improve healthy and active living among adolescents in four European countries: a protocol of the cluster randomised controlled trial of the Science Engagement to Empower aDolescentS (SEEDS) project
Authors: Wargers Annemieke , Queral Judit , Mölenberg Famke JM , Tarro Lucia , Elphick Christopher M , Kalogerakou Electra , Karagiannis Alexandros , Llauradó Elisabet , Manios Yannis , Mavrogianni Christina , Murray Claire , Vlachopoulos Dimitris , Williams Craig A , Jansen Wilma , Solà Rosa 
Published: May 2023

IntroductionImproving healthy lifestyles of adolescents is challenging. Citizen Science is a way to engage them in the design and delivery of interventions, and may also increase their interest in science, technology, engineering and mathematics (STEM). The Science Engagement to Empower aDolescentS (SEEDS) project aims to use an equity-lens, and engage and empower boys and girls from deprived areas by designing and cocreating interventions to promote healthy lifestyles, and to seed interest in STEM.Methods and analysisSEEDS is a cluster randomised controlled trial in four countries (Greece, the Netherlands, Spain and the UK). Each country will recruit six to eight high schools from lower socioeconomic neighbourhoods. Adolescents aged 13–15 years are the target population. High schools will be randomised into intervention or control group. Each country will select 15 adolescents from intervention schools called ambassadors, who will be involved throughout the project.In each country, focus groups with ambassadors and stakeholders will focus on physical activity, snacking behaviour and STEM. The input from focus groups will be used to shape Makeathon events, cocreation events where adolescents and stakeholders will develop the interventions. The resultant intervention will be implemented in the intervention schools during 6 months. In total, we aim to recruit 720 adolescents who will complete questionnaires related to healthy lifestyles and STEM outcomes at baseline (November 2021) and after the 6 months (June 2022).Ethics and disseminationThe four countries obtained approval from their corresponding Ethics Committees (Greece: Bioethics Committee of Harokopio University; the Netherlands: The Medical Research Ethics Committee of the Erasmus Medical Center; Spain: The Drug Research Ethics Committee of the Pere Virgili Health Research Institute; UK: Sport and Health Sciences Ethics Committee of the University of Exeter). Informed consent will be collected from adolescents and their parents in line with General Data Protection Regulation legislation. The findings will be disseminated by conference presentations, publications in scientific peer-reviewed journals and during (local) stakeholders and public events. Lessons learnt and the main results will also be used to provide policy recommendations.Trial registration numberNCT05002049.
Pregnancy exposure registries for drugs and vaccines in low-income and middle-income countries: scoping review protocol
Authors: AbuShweimeh Rahmeh , Knudson Sophie , Chaabane Sonia , Pal Shanthi Narayan , Skidmore Becky , Stergachis Andy , Bhat Niranjan 
Published: May 2023

IntroductionData regarding the safety of drugs and vaccines in pregnant women are typically unavailable before licensure. Pregnancy exposure registries (PERs) are an important source of postmarketing safety information. PERs in low-income and middle-income countries (LMICs) are uncommon but can provide valuable safety data regarding their distinct contexts and will become more relevant as the introduction and use of new drugs and vaccines in pregnancy increase worldwide. Strategies to support PERs in LMICs must be based on a better understanding of their current status. We developed a scoping review protocol to assess the landscape of PERs that operate in LMICs and characterise their strengths and challenges.Methods and analysisThis scoping review protocol follows the Joanna Briggs Institute manual for scoping reviews. The search strategy will be reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews Checklist. We will search PubMed, Embase, CINAHL and WHO’s Global Index Medicus, as well as the reference lists of retrieved full-text records, for articles published between 2000 and 2022 that describe PERs or other resources that systematically record exposures to medical products during pregnancy and maternal and infant outcomes in LMICs. Title and abstracts will be screened by two authors and data extracted using a standardised form. We will undertake a grey literature search using Google Scholar and targeted websites. We will distribute an online survey to selected experts and conduct semistructured interviews with key informants. Identified PERs will be summarised in tables and analysed.Ethics and disseminationEthical approval is not required for this activity, as it was determined not to involve human subjects research. Findings will be submitted to an open access peer-reviewed journal and may be presented at conferences, with underlying data and other materials made publicly available.
Polyphenylene carboxymethylene (PPCM), the active component of the topical contraceptive Yaso-GEL, exhibits potent antimicrobial activity againstNeisseria gonorrhoeaein preclinical studies
Authors: Pilligua-Lucas Michelle , Tkavc Rok , Bash Sarah K , North Barbara B , Weitzel Mary B , Jerse Ann E 
Published: May 2023

IntroductionPolyphenylene carboxymethylene (PPCM) is a condensation polymer that has both contraceptive and antimicrobial activity against several sexually transmitted viruses including HIV, herpes simplex virus, Ebola virus and SARS-CoV-2 in preclinical studies. PPCM, both as an active pharmaceutical ingredient (API) and in a vaginal gel formulation (Yaso-GEL), has an excellent safety profile. Here, we evaluated the efficacy of PPCM againstNeisseria gonorrhoeaein vitro and in a gonorrhoea mouse model.MethodsThe minimal inhibitory concentration (MIC) of PPCM was determined against 11N. gonorrhoeaestrains by agar dilution and a microtitre plate-based method. In vivo efficacy was tested in a murine model ofN. gonorrhoeaegenital tract infection by applying Yaso-GEL, PPCM incorporated in 2.7% hydroxyethylcellulose (HEC), or the HEC vehicle vaginally prior to challenge withN. gonorrhoeae. Vaginal swabs were quantitatively cultured over 5 days to assess efficacy.ResultsPPCM MIC againstN. gonorrhoeaeranged between 5–100 µg/mL (agar dilution) and 50–200 µg/mL (microtitre plate method). PPCM/HEC gel applied vaginally prior to bacterial challenge resulted in a concentration-dependent inhibition of infection. Yaso-GEL containing 4% PPCM prevented infection in 100% of mice. Incubation ofN. gonorrhoeaewith PPCM increased membrane permeability, suggesting PPCM directly compromisesN. gonorrhoeaeviability, which may be a mechanism by which PPCM inhibitsN. gonorrhoeaeinfection.ConclusionsYaso-GEL containing the API PPCM showed significant activity againstN. gonorrhoeaein vitro and in vivo in a female mouse model. These data support further development of Yaso-GEL as an inexpensive, non-hormonal and non-systemic product with both contraceptive and antimicrobial activity against gonorrhea and other common sexually transmitted infections (STIs). Such multipurpose prevention technology products are needed by women in all economic, social and cultural circumstances to prevent unintended pregnancy and STIs.
Specialist palliative care out of hours telephone advice in Ireland: a national survey
Authors: Coffey Siobháin , Twomey Feargal , Callinan Joanne , O'Reilly Martina , Coffey Alice , Holmes Jacqueline , Lucey Michael 
Published: May 2023

ObjectivesIn 2015 the All-Ireland Institute of Hospice and Palliative Care identified access to specialist palliative care (SPC) advice out of hours (OOH) as their number one research priority. Receiving appropriate advice in response to palliative care needs OOH can address a patient/family’s concerns and prevent unnecessary hospital attendances.The aim of this study was to describe the current model of SPC OOH advice in the units that run this service, and gain a greater understanding of the nature of calls received by these services.MethodsA national online survey was sent to staff providing OOH advice to patients with SPC needs and a second survey was sent to the managers of the organisations within Ireland. Surveys were emailed with a link to managers of both inpatient and community services who provide SPC.Results78 clinical staff who provide OOH telephone advice responded to the survey and there were 23 responses to the managers’ survey. The most common type of call received was in relation to symptom management (97%); however, 73% of staff indicated that they had no specific training in giving OOH advice over the phone and furthermore 44% of respondents felt ill equipped and uncomfortable giving OOH advice for a number of reasons.ConclusionsThis survey has highlighted the need for support and training to the staff providing OOH SPC advice and that a set of standards to guide practice would be useful to this cohort of staff.
Effect of dry or temper rolling of high- or low-protein wheat and its impact on rumen parameters, growth performance, and liver abscesses in feedlot cattle
Authors: Meadows Amanda C. , Terry Stephanie A. , Penner Gregory B. , Hucl Pierre J. , McAllister Tim A. , Ribeiro Gabriel O. 
Published: May 2023

This study assessed the impact of dry- (DR) versus temper-rolled (TR) and low- (13%, LP) versus high-protein (18%, HP) wheat on ruminal fermentation, growth, and liver abscesses in feedlot cattle. Crossbred Angus steers (302 ± 34 kg; n = 160; 24 ruminally cannulated) were used in a backgrounding (BG) to finishing (FN) trial. The BG diet consisted of 60% barley silage, 35% wheat, and 5% supplement, and the FN diet contained 10% barley silage, 85% wheat, and 5% supplement (dry matter basis). Four transition (TN) diets were used to adapt cattle to the FN diet. A numerical increase in large particles and reduction in small particles occurred when both HP and LP wheat were TR, with this response being greater for HP wheat. Steers experienced lower ( P ≤ 0.03) ruminal pH with HP-DR and LP-TR than HP-TR wheat during TN. Steers fed HP wheat BG diets tended to exhibit greater ( P ≤ 0.09) gain:feed and NEg than steers fed LP wheat. Greater ( P = 0.01) average daily gains were exhibited by FN steers fed LP wheat. Liver abscesses were more ( P < 0.001) severe with HP wheat. While HP wheat improved the growth of BG cattle, it increased the severity of liver abscesses during FN.