bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different interventions for the treatment of patent ductus arteriosus in children: a protocol for a network meta-analysis
Authors: Zhang Xin , Hou Xiao-Dong , Wang Wen-Xin , Yi Kang , Wang Xin-Kuan , Ding Fan , Li Xin-Xin , You Tao 
Published: March 2023

Abstract
Introduction
Patent ductus arteriosus (PDA) is one of the most common congenital heart diseases. Once the PDA is diagnosed, it needs to be dealt with in time. At present, main methods include pharmacological treatment, surgical closure, and interventional closure for treatment of PDA. However, the effect of different interventions in PDA management is still controversial. Thus, our study aims to assess the effectiveness of different interventions together and estimate the sequence of these therapies for PDA children. Meanwhile, it is necessary to conduct a Bayesian network meta-analysis to compare the safety of different interventions comprehensively.

Methods and analysis
To the best of our knowledge, this is the first Bayesian network meta-analysis comparing the efficacy and safety of different interventions for the treatment of PDA. PubMed, Embase, Cochrane Library, Web of Science, gray literature, and trial registry databases were searched from inception to December 2022. We will extract and report data according to methodological guidelines for Bayesian network meta-analysis by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). Primary PDA closure, overall PDA closure, technical success, surgical success rate, mortality during hospital stay, operation time, intensive care unit stay, intraoperative radiation dose, radiation exposure time, total postoperative complication rate, and postoperative major complication rate will be defined as the outcomes. The quality of all random studies will be assessed using ROB, and quality of evidence for all outcomes will be judged by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Ethics and dissemination
The results will be disseminated through peer-reviewed publication. Since no private and confidential patient data will be contained in the reporting, there are no ethical considerations associated with this protocol.

Systematic review registration
INPLASY2020110067.
Beyond guideline knowledge: a theory-based qualitative study of low-value preoperative testing
Authors: Jasaui Yamile , Mortazhejri Sameh , Dowling Shawn , Duquette D’Arcy , L’Heureux Geralyn , Linklater Stefanie , Mrklas Kelly J. , Wilkinson Gloria , Beesoon Sanjay , Patey Andrea M. , Ruzycki Shannon M. , Grimshaw Jeremy M. ,   on behalf of the De-Implementing Wisely Research Group
Published: March 2023

Abstract
Background
Choosing Wisely Canada and most major anesthesia and preoperative guidelines recommend against obtaining preoperative tests before low-risk procedures. However, these recommendations alone have not reduced low-value test ordering. In this study, the theoretical domains framework (TDF) was used to understand the drivers of preoperative electrocardiogram (ECG) and chest X-ray (CXR) ordering for patients undergoing low-risk surgery (‘low-value preoperative testing’) among anesthesiologists, internal medicine specialists, nurses, and surgeons.

Methods
Using snowball sampling, preoperative clinicians working in a single health system in Canada were recruited for semi-structured interviews about low-value preoperative testing. The interview guide was developed using the TDF to identify the factors that influence preoperative ECG and CXR ordering. Interview content was deductively coded using TDF domains and specific beliefs were identified by grouping similar utterances. Domain relevance was established based on belief statement frequency, presence of conflicting beliefs, and perceived influence over preoperative test ordering practices.

Results
Sixteen clinicians (7 anesthesiologists, 4 internists, 1 nurse, and 4 surgeons) participated. Eight of the 12 TDF domains were identified as the drivers of preoperative test ordering. While most participants agreed that the guidelines were helpful, they also expressed distrust in the evidence behind them (knowledge). Both a lack of clarity about the responsibilities of the specialties involved in the preoperative process and the ease by which any clinician could order, but not cancel tests, were drivers of low-value preoperative test ordering (social/professional role and identity, social influences, belief about capabilities). Additionally, low-value tests could also be ordered by nurses or the surgeon and may be completed before the anesthesia or internal medicine preoperative assessment appointment (environmental context and resources, beliefs about capabilities). Finally, while participants agreed that they did not intend to routinely order low-value tests and understood that these would not benefit patient outcomes, they also reported ordering tests to prevent surgery cancellations and problems during surgery (motivation and goals, beliefs about consequences, social influences).

Conclusions
We identified key factors that anesthesiologists, internists, nurses, and surgeons believe influence preoperative test ordering for patients undergoing low-risk surgeries. These beliefs highlight the need to shift away from knowledge-based interventions and focus instead on understanding local drivers of behaviour and target change at the individual, team, and institutional levels.
The molecular epidemiology, genotyping, and clinical manifestation of prevalent adenovirus infection during the epidemic keratoconjunctivitis, South of Iran
Authors: Afrasiabi Vahidreza , Ghojoghi Rozita , Hosseini Seyed Younes , Sarvari Jamal , Nekooei Fatemeh , Joharinia Negar , Hadian Sahar , Gholami Mohammad , Nejabat Mahmood 
Published: March 2023

Abstract
Purpose
Adenoviral-mediated keratoconjunctivitis is among the emergency diseases of ophthalmology with long-term sequels. The role of adenovirus infection, ocular-related genotypes, and association with ocular symptoms need to be investigated for epidemiological as well as clinical purposes.

Methods
The affected patients from two close keratoconjunctivitis epidemics were included in the study. The swab samples were taken from patients; the total DNA was extracted and then used as a template for in-house Real-time PCR. Besides, partial Hexon genes of 11 adenovirus positive samples were amplified and submitted to sanger sequencing. Moreover, they were finally evaluated by phylogenetic analysis.

Results
Of 153 patients, 92 (60.1%) were males and 47 cases (30.7%) had a history of eye infection in the family or colleagues. Real-time PCR tests of 126 samples (82.4%) were positive for adenovirus, and all eleven cases that underwent sequencing analysis were determined to be group 8 (HAdV-D8). Adenovirus infection has a significant relationship with infection among family or colleagues (p = 0.048), membrane formation (p = 0.047), conjunctival bleeding (p = 0.046), tearing, and pain(p < 0.05).

Conclusions
The results indicated that Adenovirus is the major cause of keratoconjunctivitis, and HAdV-D8 was the most common genotype in the area. There were some clinical manifestations associated with Adenovirus infection of the conjunctiva.
The effect of selenium therapy in critically ill patients: an umbrella review of systematic reviews and meta-analysis of randomized controlled trials
Authors: Jaff Salman , Zeraattalab-Motlagh Sheida , Amiri Khosroshahi Reza , Gubari Mohammed , Mohammadi Hamed , Djafarian Kurosh 
Published: March 2023

Abstract
Background
Selenium is an essential nutrient with antioxidant, anti-inflammatory, and immuno-regulatory properties. Studies have displayed that in critically ill patients, selenium supplementation may be a potentially promising adjunctive therapy.

Objective
We aimed to present an overview of the effects of selenium supplementation in adult critically ill patients based on published systematic reviews and meta-analyses (SRMAs) of randomized controlled trials (RCTs).

Methods
A literature search in three electronic databases, PubMed, Scopus, and Web of Science, was performed to find eligible SRMAs until July 2022. For each outcome, the risk ratios (RRs) or mean differences (MDs) and 95% confidence intervals (CIs) were recalculated using either random or fixed effect models. The methodological quality and quality of evidence of the SRMAs were assessed by applying “A Measurement Tool to Assess Systematic Reviews” (AMSTAR2) and Grading of Recommendations Assessment, Development, and Evaluation(GRADE) tools, respectively.

Results
We included 17 meta-analyses containing 24 RCTs based on inclusion criteria. Selenium supplementation can reduce the incidence of mortality (RR: 0.83, 95% CI 0.71, 0.98, P = 0.024) and incidence of acute renal failure (RR: 0.67, 95% CI 0.46, 0.98, P: 0.038) significantly; however, the certainty of evidence was low. Moreover, with moderate to very low certainty of evidence, no significant effects were found for risk of infection (RR: 0.92, 95% CI 0.80, 1.05, P: 0.207), pneumonia (RR: 1.11, 95% CI 0.72, 1.72, P: 0.675), as well as the length of ICU (MD: 0.15, 95% CI − 1.75, 2.05, P: 0.876) and hospital stay (MD: − 0.51, 95% CI − 3.74, 2.72, P: 0.757) and days on ventilation (MD: − 0.98, 95% CI − 2.93, 0.98, P: 0.329).

Conclusions
With low quality of evidence, the use of selenium supplementation could improve the risk of mortality and acute renal failure, but not other outcomes in critically ill patients.
Machine learning determination of applied behavioral analysis treatment plan type
Authors: Maharjan Jenish , Garikipati Anurag , Dinenno Frank A. , Ciobanu Madalina , Barnes Gina , Browning Ella , DeCurzio Jenna , Mao Qingqing , Das Ritankar 
Published: March 2023

AbstractBackgroundApplied behavioral analysis (ABA) is regarded as the gold standard treatment for autism spectrum disorder (ASD) and has the potentialto improve outcomes for patients with ASD. It can be delivered at different intensities, which are classified as comprehensive or focused treatment approaches. Comprehensive ABA targets multiple developmental domains and involves 20–40 h/week of treatment. Focused ABA targets individual behaviors and typically involves 10–20 h/week of treatment. Determining the appropriate treatment intensity involves patient assessment by trained therapists, however, the final determination is highly subjective and lacks a standardized approach. In our study, we examined the ability of a machine learning (ML) prediction model to classify which treatment intensity would be most suited individually for patients with ASD who are undergoing ABA treatment.MethodsRetrospective data from 359 patients diagnosed with ASD were analyzed and included in the training and testing of an ML model for predicting comprehensive or focused treatment for individuals undergoing ABA treatment. Data inputs included demographics, schooling, behavior, skills, and patient goals. A gradient-boosted tree ensemble method, XGBoost, was used to develop the prediction model, which was then compared against a standard of care comparator encompassing features specified by the Behavior Analyst Certification Board treatment guidelines. Prediction model performance was assessed via area under the receiver-operating characteristic curve (AUROC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).ResultsThe prediction model achieved excellent performance for classifying patients in the comprehensive versus focused treatment groups (AUROC: 0.895; 95% CI 0.811–0.962) and outperformed the standard of care comparator (AUROC 0.767; 95% CI 0.629–0.891). The prediction model also achieved sensitivity of 0.789, specificity of 0.808, PPV of 0.6, and NPV of 0.913. Out of 71 patients whose data were employed to test the prediction model, only 14 misclassifications occurred. A majority of misclassifications (n = 10) indicated comprehensive ABA treatment for patients that had focused ABA treatment as the ground truth, therefore still providing a therapeutic benefit. The three most important features contributing to the model’s predictions were bathing ability, age, and hours per week of past ABA treatment.ConclusionThis research demonstrates that the ML prediction model performs well to classify appropriate ABA treatment plan intensity using readily available patient data. This may aid with standardizing the process for determining appropriate ABA treatments, which can facilitate initiation of the most appropriate treatment intensity for patients with ASD and improve resource allocation.
Analytical bifurcation behaviors of a host–parasitoid model with Holling type III functional response
Authors: Yousef Ahmed M. , Rida Saad Z. , Arafat Soheir 
Published: March 2023

AbstractThis topic presents a study on a host–parasitoid model with a Holling type III functional response. In population dynamics, when host density rises, the parasitoid response initially accelerates due to the parasitoid’s improved searching efficiency. However, above a certain density threshold, the parasitoid response will reach a saturation level due to the influence of reducing the handling time. Thus, we incorporated a Holling type III functional response into the model to characterize such a phenomenon. The dynamics of the current model are discussed in this paper. We first obtained the existence and local stability conditions of the positive fixed point of the model. Furthermore, we investigated the bifurcation behaviors at the positive fixed point. More specifically, we used bifurcation theory and the center manifold theorem to prove that the model possess both period doubling and Neimark–Sacker bifurcations. Then, the chaotic behavior of the model, in the sense of Marotto, is proven. Furthermore, we apply a state-delayed feedback control strategy to control the complex dynamics of the present model. Finally, numerical examples are provided to support our analytic results.
Ethnic differences in response to atypical antipsychotics in patients with schizophrenia: individual patient data meta-analysis of randomised placebo-controlled registration trials submitted to the Dutch Medicines Evaluation Board
Authors: Storosum Bram W. C. , Steinz Cedrine , Cohen Sem E. , Mattila Taina , Brink Wim van den , Roes Kit , de Haan Lieuwe , Denys Damiaan A. J. P. , Zantvoord Jasper B. 
Published: March 2023

Background
Little is known about the effect of ethnicity on the response to antipsychotic medication in patients with schizophrenia.

Aims
To determine whether ethnicity moderates the response to antipsychotic medication in patients with schizophrenia, and whether this moderation is independent of confounders.

Method
We analysed 18 short-term, placebo-controlled registration trials of atypical antipsychotic medications in patients with schizophrenia (N = 3880). A two-step, random-effects, individual patient data meta-analysis was applied to establish the moderating effect of ethnicity (White versus Black) on symptom improvement according to the Brief Psychiatric Rating Scale (BPRS) and on response, defined as >30% BPRS reduction. These analyses were corrected for baseline severity, baseline negative symptoms, age and gender. A conventional meta-analysis was performed to determine the effect size of antipsychotic treatment for each ethnic group separately.

Results
In the complete data-set, 61% of patients were White, 25.6% of patients were Black and 13.4% of patients were of other ethnicities. Ethnicity did not moderate the efficacy of antipsychotic treatment: pooled β-coefficient for the interaction between treatment and ethnic group was −0.582 (95% CI −2.567 to 1.412) for mean BPRS change, with an odds ratio of 0.875 (95% CI 0.510–1.499) for response. These results were not modified by confounders.

Conclusions
Atypical antipsychotic medication is equally effective in both Black and White patients with schizophrenia. In registration trials, White and Black patients were overrepresented relative to other ethnic groups, limiting the generalisability of our findings.
Confinement, Environment, and Slave Ships in Early Modern Ocean Voyages
Authors: Harrigan Michael 
Published: March 2023

AbstractThis article explores how onboard sociocultural practices were shaped by different conceptions of human and external environment on seventeenth- and early eighteenth-century French ships embarking for the Indian Ocean basin or across the Atlantic to the Caribbean. In these environments, in which large numbers of people were confined together, physical conditions shaped the sensory and social dynamics of ocean voyages, while they made ships ambiguous sites for the implementation of spiritual practices. Concepts of society responded to a largely unrecognizable marine environment; shipboard conditions of physical confinement were thought conducive to moral disorder, while ships were conceived of as a source of potentially subversive human energies that had to be channeled. These tensions reached a paroxysm on the slave ships increasingly crossing the Atlantic in the seventeenth and eighteenth centuries. The conditions within early modern ships, this article contends, were exacerbated by multiple external factors, making the ship a uniquely unsustainable environment.
The Impact of Extent of Ablation on Survival of Patients With Newly Diagnosed Glioblastoma Treated With Laser Interstitial Thermal Therapy: A Large Single-Institutional Cohort
Authors: Kaisman-Elbaz Tehila , Xiao Tianqi , Grabowski Matthew M. , Barnett Gene H. , Mohammadi Alireza M. 
Published: March 2023

BACKGROUND
Upfront laser interstitial thermal therapy (LITT) can be used as part of the treatment paradigm in difficult-to-access newly diagnosed glioblastoma multiforme (ndGBM) cases. The extent of ablation, though, is not routinely quantified; thus, its specific effect on patients' oncological outcomes is unclear.

OBJECTIVE
To methodically measure the extent of ablation in the cohort of patients with ndGBM and its effect, and other treatment-related parameters, on patients' progression-free survival (PFS) and overall survival (OS).

METHODS
A retrospective study was conducted on 56 isocitrate dehydrogenase 1/2 wild-type patients with ndGBM treated with upfront LITT between 2011 and 2021. Patient data including demographics, oncological course, and LITT-associated parameters were analyzed.

RESULTS
Patient median age was 62.3 years (31-84), and the median follow-up duration was 11.4 months. As expected, the subgroup of patients receiving full chemoradiation was found to have the most beneficial PFS and OS (n = 34). Further analysis showed that 10 of them underwent near-total ablation and had a significantly improved PFS (10.3 months) and OS (22.7 months). Notably, 84% excess ablation was detected which was not related to a higher rate of neurological deficits. Tumor volume was also found to influence PFS and OS, but it was not possible to further corroborate this finding because of low numbers.

CONCLUSION
This study presents data analysis of the largest series of ndGBM treated with upfront LITT. Near-total ablation was shown to significantly benefit patients' PFS and OS. Importantly, it was shown to be safe, even in cases of excess ablation and therefore could be considered when using this modality to treat ndGBM.
Defective COX1 expression in aging mice liver
Authors: Witte Steffen , Boshnakovska Angela , Özdemir Metin , Chowdhury Arpita , Rehling Peter , Aich Abhishek 
Published: March 2023

ABSTRACT
Mitochondrial defects are associated with aging processes and age-related diseases, including cardiovascular diseases, neurodegenerative diseases and cancer. In addition, some recent studies suggest mild mitochondrial dysfunctions appear to be associated with longer lifespans. In this context, liver tissue is considered to be largely resilient to aging and mitochondrial dysfunction. Yet, in recent years studies report dysregulation of mitochondrial function and nutrient sensing pathways in ageing livers. Therefore, we analyzed the effects of the aging process on mitochondrial gene expression in liver using wildtype C57BL/6N mice. In our analyses, we observed alteration in mitochondrial energy metabolism with age. To assess if defects in mitochondrial gene expression are linked to this decline, we applied a Nanopore sequencing based approach for mitochondrial transcriptomics. Our analyses show that a decrease of the Cox1 transcript correlates with reduced respiratory complex IV activity in older mice livers.
Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia
Authors: Snodgrass Ryan O. , Govindpani Karan , Plant Karen , Kugler Elisabeth C. , Doh Changmin , Dawson Thomas , McCormack Luis E. , Arthur Helen M. , Chico Timothy J. A. 
Published: March 2023

ABSTRACT
Hereditary haemorrhagic telangiectasia (HHT) causes arteriovenous malformations (AVMs) in multiple organs to cause bleeding, neurological and other complications. HHT is caused by mutations in the BMP co-receptor endoglin. We characterised a range of vascular phenotypes in embryonic and adult endoglin mutant zebrafish and the effect of inhibiting different pathways downstream of Vegf signalling. Adult endoglin mutant zebrafish developed skin AVMs, retinal vascular abnormalities and cardiac enlargement. Embryonic endoglin mutants developed an enlarged basilar artery (similar to the previously described enlarged aorta and cardinal vein) and larger numbers of endothelial membrane cysts (kugeln) on cerebral vessels. Vegf inhibition prevented these embryonic phenotypes, leading us to investigate specific Vegf signalling pathways. Inhibiting mTOR or MEK pathways prevented abnormal trunk and cerebral vasculature phenotypes, whereas inhibiting Nos or Mapk pathways had no effect. Combined subtherapeutic mTOR and MEK inhibition prevented vascular abnormalities, confirming synergy between these pathways in HHT. These results indicate that the HHT-like phenotype in zebrafish endoglin mutants can be mitigated through modulation of Vegf signalling. Combined low-dose MEK and mTOR pathway inhibition could represent a novel therapeutic strategy in HHT.
Ammonium Ion Promoted Biodegradable Plastic Precursor D-3-Hydroxybutyrate Production from Bicarbonate and Acetone with Dual Biocatalysts System
Authors: Kita Yu , Amao Yutaka 
Published: March 2023

Abstract
Dual biocatalytic synthesis of D-3-hydroxybutyrate, a precursor of biodegradable polyester, poly-(3-hydoroxybutyrate), from CO2 and acetone via acetoacetate as an intermediate with enzyme extract including acetone carboxylase (AC) and 3-hydroxybutyrate dehydrogenase obtained from Rhodobacter capsulatus SB1003 cultured in acetone-bicarbonate medium in the presence of ATP and NADH is accomplished. The catalytic activity of AC was enhanced in the presence of ammonium chloride, and the conversion yield of acetone to D-3-hydroxybutyrate by the dual biocatalytic system was estimated to be up to 95% after 24 h incubation.