bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrathin ionic COF Membrane via Polyelectrolyte‐Mediated Assembly for Efficient CO2 Separation
Authors: Wang Shaoyu , Yang Yuhan , Liang Xu , Ren Yanxiong , Ma Hanze , Zhu Ziting , Wang Jianyu , Zeng Shichen , Song Shuqing , Wang Xuerui , Han You , He Guangwei , Jiang Zhongyi 
Published: March 2023

AbstractFabricating ultrathin covalent organic framework (COF) membranes toward high‐permeance molecular separations is highly desired yet challenging. Herein, a polyelectrolyte‐mediated assembly (PMA) strategy is developed to fabricate ultrathin ionic COF membrane for efficient CO2 separation. The PMA strategy allows a facile control over the assembly mode between polyethyleneimine (PEI) and TpPa‐SO3H, yielding PEI‐bridged ultra‐large COF nanosheets which are readily processed into COF membranes with thickness down to 8 nm. The resulting COF membranes exhibit a high CO2 permeances of 1371 GPU and CO2/N2 selectivity of 33 for stimulated flue gas. This PMA strategy may open up a new avenue to fabricating ultrathin 2D material membranes for diverse applications.
Synergistic Effects of Phase Transition and Electron‐Spin Regulation on the Electrocatalysis Performance of Ternary Nitride
Authors: Ban Jinjin , Xu Hongjie , Cao Guoqin , Fan Yameng , Pang Wei Kong , Shao Guosheng , Hu Junhua 
Published: March 2023

AbstractTransition metal nitrides (TMNs) have great potential use in energy storage and conversion owing to tunable electronic and bonding characteristics. Novel iron rich nitrides nanoparticles anchored on the N‐doped porous carbon, named as (CoxFe1–x)3N@NPC (0 ≤ x < 0.5) are designed here. The synergistic effects of phase transition and electron‐spin regulation on oxygen electrocatalysis are testified. A core–shell structure of (CoxFe1–x)3N with high dispersibility is induced by an intermediate phase transition process, which significantly suppresses coarsening of the metallic nitrides. The Co incorporation regulates d‐band electrons spin polarization. The t2g5eg1 of FeII with the ideal eg electron filling boosts intrinsic activity. (Co0.17Fe0.83)3N@NPC with optimal cobalt content holds electronic configuration with moderate eg electron filling (t2g5eg1), which balances the adsorption of *O2 and the hydrogenation of *OH, improving bifunctional catalytic performances. Both liquid and solid‐state zinc–air batteries assembled based (Co0.17Fe0.83)3N@NPC cathodes substantially deliver higher peak power density and remarkable energy density.
Near Infrared Self‐Powered Organic Photodetectors with a Record Responsivity Enabled by Low Trap Density
Authors: Liu Tianhua , Jia Zhenrong , Song Yu , Yu Na , Lin Qijie , Li Congqi , Jia Yixiao , Chen Hao , Wang Song , Wei Yanan , Lin Yuze , Huang Fei , Tang Zheng , Li Yongfang , Meng Lei , Huang Hui 
Published: March 2023

AbstractHigh‐performance IR organic photodetectors (OPDs) are of great significance for wireless optical communication, light detection and ranging (LiDAR) technology, and wearable electronics. However, high dark current and low responsivity (R) hinder their future commercial application. Herein, fullerene and non‐fullerene acceptors‐based OPDs are fabricated to understand the relationship between the trap density and photo‐responsivity. Impressively, the non‐fullerene system (Poly([2,6′‐4,8‐di(5‐ethylhexylthienyl)benzo[1,2‐b;3,3‐b]dithiophene]{3‐fluoro‐2[(2‐ethylhexyl)carbonyl]thieno[3,4‐b]thiophenediyl}) (PCE10):BTPV‐4F‐eC9) based OPDs exhibits a record R‐value of 0.56 A W−1 at 900 nm in no gain photodiode‐type OPDs, which results in a high detectivity over 1013 Jones in 400–1030 nm at room temperature. Mechanistic studies show that the low trap density plays critical role in reducing the trap‐assisted recombination and density of thermally generated carriers, thus improving the responsivity and reducing the dark current of the device. These findings provide new insights into the mechanism of high‐performance self‐powered near‐infrared OPDs.
Engineered Macrophages‐Based uPA‐Scavenger Load Gemcitabine to Prompt Robust Treating Cancer Metastasis
Authors: Rao Zhiping , Lu Chuanchuan , Fan Hongyu , Du Fuyu , Zhu Yutong , Xia Yuqiong , Wang Zhiming , Ning Pengbo 
Published: March 2023

AbstractThe majority of cancer patients die of metastasis rather than primary tumors, and most patients may have already completed the cryptic metastatic process at the time of diagnosis, making them intractable for therapeutic intervention. The urokinase‐type plasminogen activator (uPA) system is proved to drive cancer metastasis. However, current blocking agents such as uPA inhibitors or antibodies are far from satisfactory due to poor pharmacokinetics and especially have to face multiplex mechanisms of metastasis. Herein, an effective strategy is proposed to develop a uPA‐scavenger macrophage (uPAR‐MΦ), followed by loading chemotherapeutics with nanoparticles (GEM@PLGA) to confront cancer metastasis. Interestingly, significant elimination of uPA by uPAR‐MΦ is demonstrated by transwell analysis on tumor cells in vitro and enzyme‐linked immunosorbent assay detection in peripheral blood of mice with metastatic tumors, contributing to significant inhibition of migration of tumor cells and occurrence of metastatic tumor lesions in mice. Moreover, uPAR‐MΦ loaded with GEM@PLGA shows a robust antimetastasis effect and significantly prolonged survival in 4T1‐tumor‐bearing mice models. This work provides a novel living drug platform for realizing a potent treatment strategy to patients suffering from cancer metastasis, which can be further expanded to handle other tumor metastasis markers mediating cancer metastasis.
Confined Ionic‐Liquid‐Mediated Cation Diffusion through Layered Membranes for High‐Performance Osmotic Energy Conversion
Authors: Hu Yuhao , Xiao Hongyan , Fu Lin , Liu Pei , Wu Yadong , Chen Weipeng , Qian Yongchao , Zhou Shengyang , Kong Xiang‐yu , Zhang Zhen , Jiang Lei , Wen Liping 
Published: March 2023

AbstractIon‐selective membranes act as the core components in osmotic energy harvesting, but remain with deficiencies such as low ion selectivity and a tendency to swell. 2D nanofluidic membranes as competitive candidates are still subjected to limited mass transport brought by insufficient wetting and poor stability in water. Here, an ionic‐liquid‐infused graphene oxide (GO@IL) membrane with ultrafast ion transport ability is reported, and how the confined ionic liquid mediates selective cation diffusion is revealed. The infusion of ionic liquids endows the 2D membrane with excellent mechanical strength, anti‐swelling properties, and good stability in aqueous electrolytes. Importantly, immiscible ionic liquids also provide a medium, allowing partial dehydration for ultrafast ion transport. Through molecular dynamics simulation and finite element modeling, that GO nanosheets induce ionic liquids to rearrange, bringing in additional space charges, which can be coupled with GO synergistically, is proved. By mixing 0.5/0.01 m NaCl solution, the power density can achieve a record value of ≈6.7 W m−2, outperforming state‐of‐art GO‐based membranes. This work opens up a new route for boosting nanofluidic energy conversion because of the diversity of the ILs and 2D materials.
Synthese und photophysikalische Eigenschaften monometallischer C^C* Platin(II)‐Formamidinatkomplexe mit sterisch anspruchsvollen Liganden
Authors: Wurl Felix , Stipurin Sergej , Kollar Joshua Immanuel , Strassner Thomas 
Published: March 2023

AbstractEine neuartige – bisher als unzugänglich angesehene – Klasse von zyklometallierten Platin(II)‐Komplexen wurde durch eine verbesserte Syntheseroute unter Verwendung von Liganden, die durch Dichtefunktionaltheorieberechnungen vorhergesagt wurden, hergestellt. Basierend auf einem gezielten quantenchemischen Screening wurden drei Modellliganden mit unterschiedlichem sterischem Anspruch ausgewählt und eine Serie von sechs photolumineszenten Platin(II)‐Formamidinatkomplexen mit C^C* zyklometallierten Liganden hergestellt. Der Ligand mit dem geringsten sterischen Anspruch führte zu einem bimetallischen Komplex in zwei isomeren Formen, die voneinander getrennt und durch die entsprechenden Kristallstrukturen bestätigt werden konnten. Wie durch die quantenchemischen Rechnungen vorhergesagt, lieferten die sterisch stärker gehinderten Amidinatliganden die monometallischen Komplexe. Aufgrund des Verlusts der Metall‐Metall‐Wechselwirkungen zeigen diese Komplexe eine signifikante hypsochrome Verschiebung der Emissionswellenlänge. In Abhängigkeit vom zyklometallierten Ligand zeigt diese neue Klasse von Platin(II)‐Emittern grün‐blaue bis rein blaue Phosphoreszenz mit Quantenausbeuten von bis zu 87 % und kurzen Abklingzeiten.
Optochemical Control of mRNA Translation in Eukaryotes
Authors: Weissenboeck Florian P. , Schepers Helena , Rentmeister Andrea 
Published: March 2023

AbstractA major stage in the expression of genes is the translation of messenger RNA (mRNA), and the regulation of this process is essential for protein production in cells. How tightly controlled gene expression can be spatially and temporally, is particularly evident in polar cells and embryonic development. We need tools to dissect these complex processes, if we wish to understand the underlying links, especially the difficulties brought on by malfunction. External bioorthogonal triggers are very helpful in this area, if they let us precisely control where and when a process is started. Equipping nucleic acids with light‐responsive groups has proven to be an effective approach to examine the dynamic regulatory route of mRNA translation in living cells. In this review, we present an overview of the most recent methods for optochemically controlling translation, focusing on cis‐acting technologies.
X‐Ray‐triggered Carbon Monoxide and Manganese Dioxide Generation based on Scintillating Nanoparticles for Cascade Cancer Radiosensitization
Authors: Du Zhen , Wang Xin , Zhang Xiao , Gu Zhanjun , Fu Xiaoyi , Gan Shaoju , Fu Ting , Xie Sitao , Tan Weihong 
Published: March 2023

AbstractCarbon monoxide (CO) is an endogenous signaling molecule with broad therapeutic effects. Here, a multifunctional X‐ray‐triggered carbon monoxide (CO) and manganese dioxide (MnO2) generation nanoplatform based on metal carbonyl and scintillating nanoparticles (SCNPs) is reported. Attributed to the radioluminescent characteristic of SCNPs, UV‐responsive Mn2(CO)10 is not only indirectly activated to release CO by X‐ray but can also be degraded into MnO2. A high dose of CO can be used as a glycolytic inhibitor for tumor suppression; it will also sensitize tumor cells to radiotherapy. Meanwhile MnO2, as the photolytic byproduct of Mn2(CO)10, has both glutathione (GSH) depletion and Fenton‐like Mn2+ delivery properties to produce highly toxic hydroxyl radical (⋅OH) in tumors. Thus, this strategy can realize X‐ray‐activated CO release, GSH depletion, and ⋅OH generation for cascade cancer radiosensitization. Furthermore, X‐ray‐activated Mn2+ in vivo demonstrates an MRI contrast effect, making it a potential theranostic nanoplatform.
Comparison of the performances of different drying enhancers for waterborne polyvinyl alcohol films
Authors: Ahuja Sanjeev 
Published: March 2023

AbstractWaterborne polyvinyl alcohol (PVA) films show lower environmental impact but render high residual solvent on account of hydrophilicity of PVA and low volatility of water. Plasticizers have shown high potential to act as drying enhancers in some recent studies. Plasticizers triphenyl phosphate (TPP) and polyethylene glycol (PEG400) with their favorable chemical structures and relatively low molar masses are promising options. Their performances in drying waterborne PVA films are compared with the plasticizers used in earlier works, at different initial wet film thicknesses, polymer contents, enhancer contents, and enhancer molar masses. Films were solvent casted by drying PVA‐water solutions in a substrate. TPP causes maximum lowering of the residual solvent and does this at high drying rate corresponding to low initial wet film thickness and PVA content. The least value of residual solvent is 0.20% at optimum TPP loading. The next best residual solvent results of 0.21% and 0.59% are, respectively, exhibited by PEG400 and PEG6000, but at low drying rate for high wet film thickness, for both the enhancers; however, at high drying rate for low wet film thickness anomalous skinning increased the residual solvent. At 0.51%, Capstone FS‐63 also gives good results and at high drying rate. Their relative performances are correlated to the viscosity of cast solutions, glass transition temperature of films (DSC), and chemical structures of the polymer and enhancers. TPP thus proved to be most effective. SEM showed dense films and disappearance of defects with optimum loading of TPP, and TGA/DTG showed thermally stable coatings. In spite of the higher cost of TPP it can have useful specialized applications that exploit its excellent flame retardance features.
Rheological and mechanical properties, heat resistance and hydrolytic degradation of poly(butylene succinate‐co‐adipate)/stereocomplex polylactide blends
Authors: Liu Chengkai , Han Zhengyi , Yan Xiangyu , Yu Jinshuo , Zhang Qiao , Wang Dongmei , Zhao Yan , Zhang Huiliang 
Published: March 2023

AbstractIn this study, equimolar amounts of poly(l‐lactic acid) (PLLA) and poly(d‐lactide acid) (PDLA) were melt‐blended with PBSA, to obtain a novel and environmentally friendly PBSA/sc‐PLA blend, through in situ formation of stereo‐complex poly(lactic acid) (sc‐PLA). Differential scanning calorimetry and wide‐angle X‐ray diffractometry confirmed the formation of sc‐PLA in PBSA matrix. The sc‐PLA was uniformly dispersed in PBSA matrix. Up to 20 wt% sc‐PLA concentration, the PBSA/sc‐PLA blends showed solid‐like flow behavior in the low‐frequency region. Moreover, sc‐PLA could reinforce the PBSA matrix. The Young's modulus, yield strength, and storage modulus of PBSA/sc‐PLA blend increased with increase in sc‐PLA content. In addition, the heat deflection temperatures of PBSA/sc‐PLA blends increased on incorporation of sc‐PLA, thus enhancing the heat resistance. Compared with neat PBSA, the hydrolytic degradation of PBSA/sc‐PLA blends was improved. This work provides an effective strategy to obtain high performance PBSA materials and expand the application scope of PBSA.
Metformin and thymoquinone co‐treatment enhance 5‐fluorouracil cytotoxicity by suppressing the PI3K/mTOR/HIF1α pathway and increasing oxidative stress in colon cancer cells
Authors: Farrash Wesam F. , Aslam Akhmed , Almaimani Riyad , Minshawi Faisal , Almasmoum Hussain , Alsaegh Aiman , Iqbal Mohammad S. , Tabassum Aisha , Elzubier Mohamed E. , El‐Readi Mahmoud Z. , Mahbub Amani A. , Idris Shakir , Refaat Bassem 
Published: March 2023

AbstractThis study investigated the chemotherapeutic effects of 5‐fluorouracil (5‐FU), metformin (Met), and/or thymoquinone (TQ) single/dual/triple therapies in the HT29, SW480 and SW620 colon cancer (CRC) cell lines. Cell cycle/apoptosis were measured by flow cytometry. The gene and protein expression of apoptosis (PCNA/survivin/BAX/Cytochrome‐C/Caspase‐3) and cell cycle (CCND1/CCND3/p21/p27) molecules, the PI3K/mTOR/HIF1α oncogenic pathway, and glycolysis regulatory enzymes were measured by quantitative‐PCR and Western blot. Markers of oxidative stress were also measured by colorimetric assays. Although all treatments induced anti‐cancer effects related to cell cycle arrest and apoptosis, the triple therapy showed the highest pro‐apoptotic actions that coincided with the lowest expression of CCND1/CCND3/PCNA/survivin and the maximal increases in p21/p27/BAX/Cytochrome‐C/Caspase‐3 in all cell lines. The triple therapy also revealed the best suppression of the PI3K/mTOR/HIF1α pathway by increasing its endogenous inhibitors (PTEN/AMPKα) in all cell lines. Moreover, the lowest expression of lactate dehydrogenase and pyruvate dehydrogenase kinase‐1 with the highest expression of pyruvate dehydrogenase were seen with the triple therapy, which also showed the highest increases in oxidative stress markers (ROS/RNS/MDA/protein carbonyl groups) alongside the lowest antioxidant levels (GSH/CAT) in all cell lines. In conclusion, this is the first study to reveal enhanced anti‐cancer effects for metformin/thymoquinone in CRC that were superior to all monotherapies and the other dual therapies. However, the triple therapy approach showed the best tumoricidal actions related to cell cycle arrest and apoptosis in all cell lines, possibly by enhancing oxidative glycolysis and augmenting oxidative stress through stronger modulation of the PI3K/mTOR/HIF1α oncogenic network.
Biochemical and biophysical characterization of the nucleic acid binding properties of the RNA/DNA binding protein EWS
Authors: Selig Emily E. , Bhura Roohi , White Matthew R. , Akula Shivani , Hoffman Renee D. , Tovar Carmel N. , Xu Xiaoping , Booth Rachell E. , Libich David S. 
Published: March 2023

AbstractEWS is a member of the FET family of RNA/DNA binding proteins that regulate crucial phases of nucleic acid metabolism. EWS comprises an N‐terminal low‐complexity domain (LCD) and a C‐terminal RNA‐binding domain (RBD). The RBD is further divided into three RG‐rich regions, which flank an RNA‐recognition motif (RRM) and a zinc finger (ZnF) domain. Recently, EWS was shown to regulate R‐loops in Ewing sarcoma, a pediatric bone and soft‐tissue cancer in which a chromosomal translocation fuses the N‐terminal LCD of EWS to the C‐terminal DNA binding domain of the transcription factor FLI1. Though EWS was shown to directly bind R‐loops, the binding mechanism was not elucidated. In the current study, the RBD of EWS was divided into several constructs, which were subsequently assayed for binding to various nucleic acid structures expected to form at R‐loops, including RNA stem‐loops, DNA G‐quadruplexes, and RNA:DNA hybrids. EWS interacted with all three nucleic acid structures with varying affinities and multiple domains contributed to binding each substrate. The RRM and RG2 region appear to bind nucleic acids promiscuously while the ZnF displayed more selectivity for single‐stranded structures. With these results, the structural underpinnings of EWS recognition and binding of R‐loops and other nucleic acid structures is better understood.
A study of highly activated hydrogen evolution reaction performance in acidic media by 2D heterostructure of N and S doped graphene on MoOx
Authors: Aydin Kubra , Woo Seongwon , Kanade Vinit Kaluram , Choi Seulgi , Ahn Chisung , Lim Byungkwon , Kim Taesung 
Published: March 2023

AbstractHerein, a layer of molybdenum oxide (MoOx), a transition metal oxide (TMO), which has outstanding catalytic properties in combination with a carbon‐based thin film, is modified to improve the hydrogen production performance and protect the MoOx in acidic media. A thin film of graphene is transferred onto the MoOx layer, after which the graphene structure is doped with N and S atoms at room temperature using a plasma doping method to modify the electronic structure and intrinsic properties of the material. The oxygen functional groups in graphene increase the interfacial interactions and electrical contacts between graphene and MoOx. The appearance of surface defects such as oxygen vacancies can result in vacancies in MoOx. This improves the electrical conductivity and electrochemically accessible surface area. Increasing the number of defects in graphene by adding dopants can significantly affect the chemical reaction at the interfaces and improve the electrochemical performance. These defects in graphene play a crucial role in the adsorption of H+ ions on the graphene surface and their transport to the MoOx layer underneath. This enables MoOx to participate in the reaction with the doped graphene. N‐ and S‐doped graphene (NSGr) on MoOx is active in acidic media and performs well in terms of hydrogen production. The initial overpotential value of 359 mV for the current density of −10 mA/cm2 is lowered to 228 mV after activation.
Phase‐Dependent Long Persistent Phosphorescence in Coumarin‐Phosphine‐Based Coinage Metal Complexes
Authors: Naina Vanitha R. , Singh Akhil K. , Rauthe Pascal , Lebedkin Sergei , Gamer Michael T. , Kappes Manfred M. , Unterreiner Andreas‐Neil , Roesky Peter W. 
Published: March 2023

AbstractA coumarin functionalized aminodiphosphine has been introduced as a bidentate ligand in coinage metal chemistry. Mono‐, di‐, and trimetallic copper and silver complexes were synthesized with this ligand. The hybrid character of the ligand led to compounds with rich luminescence properties. These include coumarin‐based blue fluorescence, observed as a sole emission in solution at room temperature, and green phosphorescence, which is efficient at low temperatures and dominates the spectra of the metal complexes. In the rigid environment of frozen solutions, the green phosphorescence shows an unusually long (for metal complexes) decay on the seconds timescale in high quantum yield. In addition, a red phosphorescence, which may be assigned to the triplet state localized in the phosphine‐M3Cl2(M=Cu, Ag), is observed for the trinuclear complexes at low temperature. Neither the second‐long phosphorescence nor the red emission is observed for the coumarin ligand, thus they must be a result of the coordination to coinage metal clusters. The excited states in these compounds were also investigated by femtosecond transient absorption spectroscopy and quantum chemical calculations.
Primary osteosarcoma of the ribs: A report from the Cooperative Osteosarcoma Study Group
Authors: Bodmer Nicole , Hecker‐Nolting Stefanie , Friedel Godehard , Blattmann Claudia , Kager Leo , Kessler Torsten , Kevric Matthias , Kühne Thomas , Mettmann Vanessa , Müller‐Abt Peter , Sorg Benjamin , Theobald Matthias , Bielack Stefan S. 
Published: March 2023

AbstractPurposePrimary rib osteosarcoma has not been investigated extensively, and clinical characteristics and optimal therapeutic strategies have not been defined. The authors used the database of the Cooperative Osteosarcoma Study Group (COSS) to analyze this tumor‐site in depth.MethodsThe COSS database was searched for treatment‐naive, high‐grade osteosarcomas of the rib. Affected patients were analyzed for demographic and tumor‐related factors, treatments, and outcomes.ResultsA total of 44 patients (23 males, 21 females; median age, 23 years [range, 6–59]) were identified. Primary metastases were detected in six of 44 (14%) patients. Surgery was performed in 40 of 44 (91%) patients and rendered 35 of 44 (80%) patients macroscopically disease‐free. Chemotherapy was known to have been administered in 43 of 44 (98%) patients and radiotherapy in seven of 42 (17%) (no data for two patients). A good response to chemotherapy was only noted in five (33%) of those 15 evaluable patients who had received any preoperative chemotherapy. After a median follow‐up of 2.49 (0.22–40.35) years for all patients and 6.61 (0.25–40.35) years for 26 survivors (21 of these in first complete remission), 5‐year actuarial overall and event‐free survival were 53.0% (8.5%) and 42.2% (8.1%), respectively. Incomplete tumor surgery was the most notable negative prognostic factor. Osteoblastic histology and a poor response to chemotherapy may have contributed.ConclusionThis large series provides evidence that patients with costal primaries are older than the average osteosarcoma patient, but appear to share the similar tumor biology and—if treated according to standard protocols—prognostic factors with tumors of other sites. Early, preoperative diagnosis and permanent, definitive local control remain major challenges and should contribute to improved outcomes.