bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA Nanostructures‐Based In Situ Cancer Vaccines: Mechanisms and Applications
Authors: Lin Bingyu , Liu Yanfei , Chen Qiwen , Li Mingfeng , Xu Lishang , Chen Qianqian , Tan Yifu , Liu Zhenbao 
Published: January 2025

AbstractCurrent tumor vaccines suffer from inadequate immune responsive due to the insufficient release of tumor antigens, low tumor infiltration, and immunosuppressive microenvironment. DNA nanostructures with their ability to precisely engineer, controlled release, biocompatibility, and the capability to augment the immunogenicity of tumor microenvironment, have gained significant attention for their potential to revolutionize vaccine designing. This review summarizes various applications of DNA nanostructures in the construction of in situ cancer vaccines, which can generate tumor‐associated antigens directly from damaged tumors for cancer immune‐stimulation. The mechanisms and components of cancer vaccines are listed, the specific strategies for constructing in situ vaccines using DNA nanostructures are explored and their underlying mechanisms of action are elucidated. The immunogenic cell death (ICD) induced by chemotherapeutic agents, photothermal therapy (PTT), photodynamic therapy (PDT), and radiation therapy (RT) and the related cancer vaccines building strategies are systematically summarized. The applications of different DNA nanostructures in various cancer immunotherapy are elaborated, which exerts precise, long‐lasting, and robust immune responses. The current challenges and future prospectives are proposed. This review provides a holistic understanding of the evolving role of DNA nanostructures for in situ vaccine development.
Chemical Looping: A Sustainable Approach for Upgrading Light Hydrocarbons to Value‐Added Olefins
Authors: Alabi Sherif , Gambo Yahya , Adamu Sagir , Hossain Mohammad Mozahar 
Published: January 2025

AbstractIn recent times, chemical looping offered a sustainable alternative for upgrading light hydrocarbons into olefins. Olefins are valuable platform chemicals that are utilized for diverse applications. To close the wide shortfall in their global supply, intensified efforts are ongoing to develop on‐purpose production technologies. Herein, we provide discussions on the emerging olefin production routes and chemical looping as a frontier concept in catalytic production of chemicals, especially light olefins. Moreover, we discuss the various rational strategies for designing and tuning of oxygen carriers with high catalytic activity and tailored selectivity to desired products. These strategies include creation of oxygen vacancies, controlled doping, synergistic metal‐support interactions, regulating oxygen mobility, modulation of crystal structure, functionalization and controlled treatment. The insights presented aim to inspire the development of robust, stable, and efficient oxygen carriers, ensuring catalytic activity, selectivity, and prolonged operational stability.
Numerical assessment of tool geometry for improving productivity in milling stainless steel 316 L
Authors: Malekan Mohammad , Madsen Karoline L. , Airao Jay , Ilvig Charlotte F. , Aghababaei Ramin 
Published: January 2025

Abstract
Improving the material removal rate (MRR) can significantly enhance the efficiency of the milling operations during machining. However, increasing MRR develops a larger degree of stress and eventual wear at the cutting edge, reducing the tool’s lifetime, in particular for hard metals like stainless steel. Therefore, it is important to optimize the tool geometry to enhance the stress-carrying capacity under extreme cutting conditions. Considering a four-fluted tungsten carbide milling tool for cutting stainless steel, we propose in this study a procedure for reducing tool stresses by modifying the tool geometry. Using a systematic set of finite element simulations, we showed that the degree of stresses on the cutting edge can be reduced by optimizing three geometrical parameters, i.e., helix angle, rake angle, and cutting edge radius. To validate the simulation results, we manufactured 18 four-fluted milling tools with varying geometries and tested them by milling stainless steel 316 L under identical cutting conditions. The performance of each tool was ranked based on microscopic inspections of their cutting edges, showing a close agreement with the numerical simulation predictions. This study presents a procedure for modifying milling tool geometry to enhance performance under extreme machining conditions.
Hausdorff dimension of the Apollonian gasket
Authors: Vytnova Polina L. , Wormell Caroline L. 
Published: January 2025

Abstract
The Apollonian gasket is a well-studied circle packing. Important properties of the packing, including the distribution of the circle radii, are governed by its Hausdorff dimension. No closed form is currently known for the Hausdorff dimension, and its computation is a special case of a more general and hard problem: effective, rigorous estimates of dimension of a parabolic limit set. In this paper we develop an efficient method for solving this problem which allows us to compute the dimension of the gasket to 128 decimal places and rigorously justify the error bounds. We expect our approach to generalise easily to other parabolic fractals.
The Diagnosis and Therapy of Osteoporosis in Gaucher Disease
Authors: Marcucci Gemma , Brandi Maria Luisa 
Published: January 2025

Abstract
Gaucher disease is a rare lysosomal storage disorder characterized by the accumulation of glucocerebroside lipids within multiple organs due to a deficiency of the lysosomal enzyme (acid β-glucosidase). It is an inherited autosomal recessive disease. The onset of symptoms can vary depending on disease type and severity, with milder forms presenting in adulthood. The main clinical manifestations include cytopenia, splenomegaly, hepatomegaly, and bone lesions. GD is characterized by several bone manifestations, such as osteopenia/osteoporosis, focal lytic or sclerotic lesions, osteonecrosis acute or chronic bone pain, Erlenmeyer flask deformity, and subchondral joint collapse with secondary degenerative arthritis. In 70–100% of patients affected by Gaucher disease type 1, clinical or radiographic evidence of bone disease occurs. Among bone complications, osteoporosis is very common, but its etiopathogenesis in GD is not completely clear. Results deriving from experimental studies support the hypothesis that there is an aberrant activity of both osteoclasts and osteoblasts due to several factors, resulting in impaired bone turnover. Bone complications represent the main cause of pain, disability, and reduced quality of life in these patients. Therefore, there is a need to enhance awareness among physicians on the skeletal manifestations throughout life of GD patients, in order to improve diagnosis and management of bone complications. In particular, this narrative review focuses on risk of bone fragility in GD, etiopathogenetic hypotheses, epidemiological data, diagnosis, monitoring, and treatment of osteoporosis in patients suffering from Gaucher disease, specifying the challenges not yet addressed.
Pulmonary Atresia with Intact Ventricular Septum, an Evolving Strategy in the Era of PDA Stenting: Single Center Experience
Authors: Shibbani Kamel , Nigro John , Rao Rohit , Gordon Brent M. , Justino Henri , AlShawabkeh Laith , El-Said Howaida 
Published: January 2025

Abstract
Repair or palliation of pulmonary atresia with intact ventricular septum (PA/IVS) often falls into one of 4 categories: cardiac transplant, 2-ventricular circulation, 1.5 ventricle circulation, or single ventricle circulation. The optimal management strategy has been an area of much debate. We sought to review the management strategy of patients with PA/IVS at our institution to better understand what metrics can be used to guide management and initial interventions. The study aims to examine the outcomes of a single-center approach to managing patients with PA/IVS. Our cohort included 29 patients; one patient underwent a planned transplant at ten days of life (3.4%), 12 underwent repair via a two-ventricle circulation (41.4%), 7 underwent repair with 1.5 ventricle circulation (24.1%), and 7 underwent repair with single ventricle circulation (24.1%). Survival was achieved in 93.1% with two patients (6.9%) expiring. The TV annulus z-score was significantly different between the three groups, with the 1 V group having the smallest median TV annulus z-score at − 4.04 (IQR − 4.60– − 3.60) and the 2 V group having the largest median TV z-score at − 1.4 (IQR − 2.24– − 0.12). Six patients underwent late right ventricular decompression. We present a post-hoc algorithm to help guide treatment strategies for patients with PA/IVS.
The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings
Authors: Paddock Michael , Bains Parasdeep S. , Kvist Ola , Andronikou Savvas , Franchi-Abella Stephanie , van Rijn Rick R. , Arthurs Owen J. , Offiah Amaka C. ,   ESPR Publications Committee (consortium)
Published: January 2025

Abstract

Background
The European Society of Paediatric Radiology (ESPR) awards prizes for outstanding work presented at their annual scientific meetings. The proportion of ESPR prize-winning abstracts to journal publications is not known. Contextualising abstract-to-publication proportions by evaluating publication experience can yield valuable insights and actionable outcomes to support researchers in overcoming barriers to journal publication.

Objective
To assess the abstract-to-publication proportion of prize-winning ESPR abstracts and prize-winning authors’ experience of publishing in Pediatric Radiology, the affiliated journal of the ESPR and other specialist international paediatric radiology societies.

Materials and methods
PubMed was searched for titles of ESPR prize-winning abstracts from 1977 (the year of first award) up to and including 2021, where the presenter was either first or co-author, and the article was published 2 years before or after the presentation year. If not found, a general internet search was performed. Titles of all retrieved articles were evaluated for inclusion. A survey was distributed to all ESPR prize winners to better understand their experiences around journal submission.

Results
Over 44 years, 108 prizes were awarded. The prize-winning abstract-to-publication proportion was significantly higher (59.3%, OR=2.10, P=0.012) than the recently published pediatric radiology “abstract to publication rate” (41.9% from 2013–2016). Moreover, prize winners were more than twice as likely than to achieve journal publication (OR=2.10), and as first author (OR=1.33). The majority of awardees published their work as first author (52/64, 81.3%): the first-author abstract-to-publication proportion was not significantly higher than the paediatric radiology “abstract-to-publication rate” (48.1%, OR=0.33, P=0.330). Sixty-four survey responses were received (59.3%, out of a total 108 awarded prizes). Just over 20% of prize-winning work was published in Pediatric Radiology, with 41.5% of respondents reporting a good to excellent submission experience.

Conclusion
Prize-winning and first-author abstract-to-publication proportions are higher for ESPR-awarded abstracts than the most recently reported paediatric radiology “abstract-to-publication rate”, suggesting that prizes are either awarded to work most likely to be published or that being awarded a prize encourages publication. Given that just over 40% of prize-winning abstracts remain unpublished, the ESPR should do more to support and encourage all authors to publish their work.
On-the-fly resolution enhancement in X-ray protein crystallography using electric field
Authors: Khakurel Krishna Prasad , Nemergut Michal , Pant Purbaj , Savko Martin , Andreasson Jakob , Žoldák Gabriel 
Published: January 2025

Abstract
X-ray crystallography has tremendously served structural biology by routinely providing high-resolution 3D structures of macromolecules. The extent of information encoded in the X-ray crystallography is proportional to which resolution the crystals diffract and the structure can be refined to. Therefore, there is a continuous effort to obtain high-quality crystals, especially for those proteins, which are considered difficult to crystallize into high-quality protein crystals of suitable sizes for X-ray crystallography. Efforts in enhancing the resolution in X-ray crystallography have also been made by optimizing crystallization protocols using external stimuli such as an electric field and magnetic field during the crystallization. Here, we present the feasibility of on-the-fly post-crystallization resolution enhancement of the protein crystal diffraction by applying a high-voltage electric field. The electric field between 2 and 11 kV/cm, which was applied after mounting the crystals in the beamline, resulted in the enhancement of the resolution. The crystal diffraction quality improved progressively with the exposure time. Moreover, we also find that upto defined electric field threshold, the protein structure remains largely unperturbed, a conclusion further supported by molecular dynamics simulations.
A Snapshot of United States Sarcoidosis Patients and their Perceived Disease Impact: Results of the Sarcoidosis Research Institute Survey
Authors: Obi Ogugua Ndili , Polite Paula Yette , Fish Kenneth M. , DeLuca Robert , Feustel Paul J. , Mandis Alexandra E. , Coleman Annetta M. , Judson Marc A. 
Published: January 2025

Abstract

Purpose
The priorities and concerns of sarcoidosis patients in the United States (US) have not been well-described.

Methods
A survey constructed by sarcoidosis patients and doctors was administered to US sarcoidosis patients. The survey queried patients concerning their demographics, disease state, disease impact on health and well-being, health care priorities and impressions of sarcoidosis care. Respondents were solicited via social media and networking with sarcoidosis clinicians.

Results
1018 US sarcoidosis patients completed this survey. 65% were female, 63% White, 34% Black, and 87% > 45 years old. The most common organs involved were the lungs 87%, skin 30%, heart 25%, and eyes 25%. Household income was < $50 K in 31% and > $150 K in 14% of patients. There was a fairly even split between those living in urban (29%), suburban (42%), and rural (29%) environments. The patients’greatest concerns were fear of worsening disease, fear of sarcoidosis developing in more organs, and fear of sarcoidosis not improving. These were closely followed by concerns about poor health-related quality of life (HRQoL), inability to enjoy everyday activities, lack of medical research, disability from sarcoidosis, and pulmonary function status. Lack of physician knowledge and poor physician communication were ranked of lowest concern. Concerns about ineffective medications and cost of medical care were also ranked relatively low. Patients overwhelmingly considered information from their doctor as very useful.

Conclusion
In this survey of over 1000 US sarcoidosis patients, their greatest concerns were fear of poor clinical outcomes. The patients were relatively less concerned about their doctors’ knowledge about sarcoidosis and poor physician communication. Although patients expressed significant concerns about poor HRQoL, not all domains of HRQoL were equally affected. US sarcoidosis patients rank concerns about disease progression higher than disease impact on HRQoL.
Analysis and Generation of Rough-Surfaced Fractures with Variable Aperture Based on Self-Affine Methods Using Surface Scan Measurements
Authors: Stock Brandon , Frampton Andrew 
Published: January 2025

Abstract
Methods founded on self-affine principles have successfully been used to generate synthetic rough-surfaced fractures, which can be based on properties inferred from measurements of fracture surfaces. Two key parameters, the Hurst exponent H and a scaling parameter Sp, together with a function describing the correlation between the surfaces forming the fracture, are needed. There are several methods for determining H and Sp in the literature, which are primarily adopted for measurements of 1-dimensional fracture traces. However, comparatively few studies have used these methods and applied them to aperture generation. In this study, we evaluate two commonly employed methods, the root-mean-square correlation function (RMS-COR) and the Fourier power spectrum (FPS) approach, each with several variations of their possible implementation when applied to measurements of fracture surfaces. We use high-resolution surface scans of a natural fracture sample to obtain an accurate representation of the aperture field and rough surfaces. Multiple realisations of aperture fields are generated for each method variation and their respective ensembles are evaluated against the aperture distribution of the measured fracture sample. For the fracture studied, the RMS-COR method is the most accurate method for obtaining H and Sp. We show that a linear relationship exists between H and Sp which provides a best fit of synthetically generated fractures when compared to the measured sample. Additionally, we introduce an improved approach for representing the correlation function between the two rough surfaces. Finally, we demonstrate that the model can successfully generate upscaled fracture apertures based on restricted subsections of the sample.
Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis
Authors: Lipovec Tina , Kapadia N. , Antonoglou G. N. , Lu E. M. C. , El-Sayed K. M. Fawzy , Nibali Luigi 
Published: January 2025

Abstract

Objective
To evaluate the possible additional clinical benefit from autologous platelet concentrate (APC) treatment adjunct to non-surgical periodontal therapy (NSPT).

Methods
Electronic (MEDLINE/Embase/Cochrane/MedNar/CORE) and hand searches were conducted. Following studies selection, evidence tables were formed, and meta-analyses were performed for the following outcomes: probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, and bleeding on probing (BoP) reduction. The protocol for this systematic review was registered in PROSPERO (CRD42023514388).

Results
After de-duplication, the initial search yielded 194 citations, from which ten papers were eligible for quantitative synthesis. The APC group comprised 270 patients, while the control group included 230. The meta-analysis revealed that a single APC application resulted in a 0.6 mm greater PPD reduction (MD = -0.62; 95% CI: -1.03, -0.22) and 0.8 mm more CAL gain (MD = -0.77; 95% CI: -1.18, -0.37) at the 6–12 weeks follow-up. At six months, the APC group exhibited a 0.6 mm greater PPD reduction (MD = -0.61; 95% CI: -1.13, -0.09) and 1.1 mm more CAL gain (MD = -1.14; 95% CI: -1.94, -0.34) compared to the NSPT only group. In contrast, BoP indices did not reveal a statistically significant difference between the groups after 6–12 weeks (MD = -10.54; 95% CI: -25.21, 4.14). High heterogeneity and unclear to high risk of bias were detected.

Conclusion
Over six months, the adjunctive APC use appears to provide additional benefits in PPD reduction and CAL gain compared to NSPT alone.

Clinical relevance
The adjunctive use of APCs seems to promote further improvements in clinical outcomes following NSPT.
Do Uncertainties in US Affect Bitcoin Returns? Evidence from Time Series Analysis
Authors: Miba’am Benjamin Walwai , Güngör Hasan 
Published: January 2025

Abstract
The study attempts to add to the existing literature on the relationship between uncertainties and Bitcoin by determining the direction of the relationship between Economic Policy Uncertainty (EPU), Geopolitical Risk (GPR), Political Risk (PR) and Bitcoin returns. This is to ascertain if Bitcoin hedges and is a safe haven asset against uncertainties. We employed the use of Ordinary Least Square (OLS), Autoregressive Distributive Lag (ARDL) and Quantile Regression (QR) to achieve the research objective. Having discovered the existence of structural breaks after conducting the Zivot-Andrews unit root for structural breaks, the analysis was divided into full sample period, first sub-period and the second sub-period. Findings show that EPU, GPR and PR hedge and play the role of safe haven against uncertainties in the United States (US). We found that EPU exerts positive influence against Bitcoin returns while GPR and PR negatively influence Bitcoin returns. The result further shows that Bitcoin returns hedges against EPU in the lower and middle quantiles while Bitcoin returns hedges against PR only in the lower quantile. The study therefore concludes that uncertainty and risk in the US influence bitcoin returns. It supports the hedging ability and safe haven properties of bitcoin, emphasising that bitcoin returns react more to EPU US than GPR US and PR US, therefore recommending investment experts and financial analysts focus more on EPU US than GPR US and PR US.
Covariant single-field formulation of effective cosmological bounces
Authors: Miranda Marcello 
Published: January 2025

Abstract
This study explores the feasibility of an effective Friedmann equation in removing the classical Big Bang initial singularity and replacing it with a non-singular bounce occurring at a critical energy density value. In a spatially flat, homogeneous, and isotropic universe, the effective theory is obtained by introducing a function parametrically dependent on the critical energy density. This function measures the deviation from the benchmark theory, which is recovered as the critical energy density approaches infinity. Focusing on the covariant single-field formulation in viable Horndeski gravity, our analysis shows that both the effective and the benchmark theories belong to the same scalar–tensor theory, without any additional propagating degrees of freedom: the cuscuton and extended cuscuton models.
Interference cancellation to enhance bit error rate using the YOLO-CSE model
Authors: Salama Wessam M. 
Published: January 2025

Abstract
A novel framework based on combining the You Only Look Once-CSE (YOLO-CSE) model is implemented in this paper with Communication Visible Light (CVL) and Multiple Access non-orthogonality (MANO-CVL) for Multiple Input and Output (MIMO). The main goal of the proposed model is to decrease the detecting error in the received bits and distinguish between noise signal and correct bits. The YOLO-CSE model uses the Yolov5 model as a backbone. Two sorts of regulation are applied; position modulation (L-PPM) with different L and users, inside a Comparable Gain Combiner (CGC) at the recipient. This framework thinks about

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and

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clients in the ideal and non-ideal Cancellation of Successive Interferences (CSI). Because of the YOLO-CSE model, the error execution is additionally considered versus the power portion coefficient (α) for

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n

and

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m

clients switching keying (OOK) balance Single Input and Output (SISO),

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,
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d

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for CVL based on utilizing the MANO and MIMO frameworks. The proposed model focuses on the significant highlights that have been removed from the dataset by utilizing the Convolutional unit (CBAU). The Fast-Pooling Spatial Pyramid (SPPF +) is likewise applied to the extricated highlights to reuse them. In that unique situation, the exponential block is coordinated to enact the capability for additional exact outcomes. The modified model, YOLO-CSE outperforms the other models in the literature by 18% outperform the other models in the literature.