bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Minimum Necessary Rigor” in empirically evaluating human–AI work systems
Authors: Klein Gary , Hoffman Robert R. , Clancey William J. , Mueller Shane T. , Jentsch Florian , Jalaeian Mohammadreza 
Published: August 2023

AbstractThe development of AI systems represents a significant investment of funds and time. Assessment is necessary in order to determine whether that investment has paid off. Empirical evaluation of systems in which humans and AI systems act interdependently to accomplish tasks must provide convincing empirical evidence that the work system is learnable and that the technology is usable and useful. We argue that the assessment of human–AI (HAI) systems must be effective but must also be efficient. Bench testing of a prototype of an HAI system cannot require extensive series of large‐scale experiments with complex designs. Some of the constraints that are imposed in traditional laboratory research just are not appropriate for the empirical evaluation of HAI systems. We present requirements for avoiding “unnecessary rigor.” They cover study design, research methods, statistical analyses, and online experimentation. These should be applicable to all research intended to evaluate the effectiveness of HAI systems.
Biomimetic Nanophotosensitizer Amplifies Immunogenic Pyroptosis and Triggers Synergistic Cancer Therapy
Authors: Wang Qian , Qin Weiji , Qiao Lei , Gao Min , Zhou Man , Zhang Huiru , Sun Qiuting , Yao Wanqing , Yang Tianhao , Ren Xiaohe , Sun Gengyun , He Xiaoyan 
Published: August 2023

AbstractImmunotherapy is considered to be an effective treatment for cancer and has drawn extensive interest. Nevertheless, the insufficient antigenicity and immunosuppressive tumor microenvironment often cause unsatisfactory therapeutic efficacy. Herein, a photo‐activated reactive oxygen species (ROS) amplifying system (defined as “M‐Cu‐T”) is developed to induce antitumor immune response by triggering a tumor‐specific immunogenic pyroptosis. In M‐Cu‐T, M1 macrophage membrane‐based vesicles are used for drug loading and tumor targeting, photosensitizers (meso‐tetra(4‐aminophenyl) porphyrin, TAPP) are used as a pyroptosis inducer, copper ions (Cu2+) can enhance ROS‐induced pyroptosis by consuming antioxidant systems in cells. As expected, the prepared M‐Cu‐T targets enrichment into tumor cells and cascades the generation of ROS, which further induces pyroptosis through caspase 3‐mediated gasdermin E (GSDME) cleavage under laser activation. The pyroptotic cancer cells accompanying secrete related pattern molecules, induce immunogenic cell death, and activate antitumor immunity for immunotherapy. An effective tumor ablation is observed in LLC and CT26 cancer mouse models. This study provides inspiration for boosting the immunogenicity and achieving satisfactory therapeutic effects in cancer therapy.
Self‐Oxidation Resistance of the Curved Surface of Achromatic Copper
Authors: Kim Young‐Hoon , Kim Seong‐Gon , Lee Seunghun , Cheon Miyeon , Kim Su Jae , Nam Kideuk , Lamichhane Bipin , Park Sung Heum , Jung Min‐Hyoung , Kim Ji‐Soo , Seo Yu‐Seong , Ha Taewoo , Hwang Jungseek , Jeong Hu Young , Lee Yusil , Lee Young Hee , Kim Young‐Min , Jeong Se‐Young 
Published: August 2023

AbstractCopper surfaces that exhibit a wide range of achromatic colors while still metallic have not been studied, despite advancements in antireflection coatings. A series of achromatic copper films grown with [111] preferred orientation by depositing 3D porous nanostructures is introduced via coherent/incoherent atomic sputtering epitaxy. The porous copper nanostructures self‐regulate the giant oxidation resistance by constructing a curved surface that generates a series of monoatomic steps, followed by shrinkage of the lattice spacing of one or two surface layers. First‐principles calculations confirm that these structural components cooperatively increase the energy barrier against oxygen penetration. The achromaticity of the single‐crystalline porous copper films is systematically tuned by geometrical parameters such as pore size distribution and 3D linkage. The optimized achromatic copper films with high oxidation resistance show an unusual switching effect between superhydrophilicity and superhydrophobicity. The tailored 3D porous nanostructures can be a candidate material for numerous applications, such as antireflection coatings, microfluidic devices, droplet tweezers, and reversible wettability switches.
Plasma‐Etched Nanograss Surface without Lithographic Patterning to Immobilize Water Droplet for Highly Sensitive Raman Sensing
Authors: Ho Hsiuan Ling , Yang Jung Yen , Lin Chun Hung , Shieh Jiann , Fang Huang Yu , Ho Yi Hong , Ko Tsung Shine , Hsu Chiung Chih , Ostrikov Kostya (Ken) 
Published: August 2023

AbstractThe development of reliable, cost‐effective molecular detection at the attomolar level on analyte‐immobilizing surfaces fabricated without lithographic patterning remains a major challenge in chemical sensing technology. This issue is addressed using custom‐designed adhesive superhydrophobic silicon nanograss surfaces produced via plasma etching. When applied to ultrasensitive surface‐enhanced Raman scattering, the nanograss surface enables effective immobilization of water droplets containing Ag nanoparticles and R6G target molecules. Upon water evaporation, the R6G analytes are confined at the edge of the self‐organized coffee‐ring‐like stains with the plasmonic hot spots of the Ag nanoparticles, thus providing a reliable Raman scattering platform for detecting trace analytes. Even at an ultralow concentration of 10−16 m, the corresponding relative standard deviation is 17.57%. A novel plasma‐enabled approach for precise interface nanostructuring, potentially leading to unprecedented capabilities in molecular‐level sensing technologies, is presented.
eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer
Authors: Pan Qihao , Yu Fenghai , Jin Huilin , Zhang Peng , Huang Xiaoling , Peng Jingxuan , Xie Xiaoshan , Li Xiangli , Ma Ning , Wei Yue , Wen Weijie , Zhang Jieping , Zhang Boyu , Yu Hongyan , Xiao Yuanxun , Liu Ran‐yi , Liu Qingxin , Meng Xiangqi , Lee Mong‐Hong 
Published: August 2023

AbstractNumerous studies have demonstrated that individual proteins can moonlight. Eukaryotic Initiation translation factor 3, f subunit (eIF3f) is involved in critical biological functions; however, its role independent of protein translation in regulating colorectal cancer (CRC) is not characterized. Here, it is demonstrated that eIF3f is upregulated in CRC tumor tissues and that both Wnt and EGF signaling pathways are participating in eIF3f's oncogenic impact on targeting phosphoglycerate dehydrogenase (PHGDH) during CRC development. Mechanistically, EGF blocks FBXW7β‐mediated PHGDH ubiquitination through GSK3β deactivation, and eIF3f antagonizes FBXW7β‐mediated PHGDH ubiquitination through its deubiquitinating activity. Additionally, Wnt signals transcriptionally activate the expression of eIF3f, which also exerts its deubiquitinating activity toward MYC, thereby increasing MYC‐mediated PHGDH transcription. Thereby, both impacts allow eIF3f to elevate the expression of PHGDH, enhancing Serine–Glycine–One–Carbon (SGOC) signaling pathway to facilitate CRC development. In summary, the study uncovers the intrinsic role and underlying molecular mechanism of eIF3f in SGOC signaling, providing novel insight into the strategies to target eIF3f‐PHGDH axis in CRC.
Force Generation in the Coiling Tendrils of Passiflora caerulea
Authors: Klimm Frederike , Speck Thomas , Thielen Marc 
Published: August 2023

AbstractTendrils of climbing plants coil along their length, thus forming a striking helical spring and generating tensional forces. It is found that, for tendrils of the passion flower Passiflora caerulea, the generated force lies in the range of 6–140 mN, which is sufficient to lash the plant tightly to its substrate. Further, it is revealed that the generated force strongly correlates with the water status of the plant. Based on a combination of in situ force measurements with anatomical investigations and dehydration‐rehydration experiments on both entire tendril segments and isolated lignified tissues, a two‐phasic mechanism for spring formation is proposed. First, during the free coiling phase, the center of the tendril begins to lignify unilaterally. At this stage, both the generated tension and the stability of the form of the spring still depend on turgor pressure. The unilateral contraction of a bilayer as being the possible driving force for the tendril coiling motion is discussed. Second, in a stabilization phase, the entire center of the coiled tendril lignifies, stiffening the spring and securing its function irrespective of its hydration status.
IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption
Authors: Cui Xuan , Liu Haojie , Shi Ting , Zhao Qingwen , Li Feiyan , Lv Wenjing , Yu Chao , Huang Haiyan , Tang Qi‐Qun , Pan Dongning 
Published: August 2023

AbstractMitochondria are the pivot organelles to control metabolism and energy homeostasis. The capacity of mitochondrial metabolic adaptions to cold stress is essential for adipocyte thermogenesis. How brown adipocytes keep mitochondrial fitness upon a challenge of cold‐induced oxidative stress has not been well characterized. This manuscript shows that IFI27 plays an important role in cristae morphogenesis, keeping intact succinate dehydrogenase (SDH) function and active fatty acid oxidation to sustain thermogenesis in brown adipocytes. IFI27 protein interaction map identifies SDHB and HADHA as its binding partners. IFI27 physically links SDHB to chaperone TNF receptor associated protein 1 (TRAP1), which shields SDHB from oxidative damage‐triggered degradation. Moreover, IFI27 increases hydroxyacyl‐CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA) catalytic activity in β‐oxidation pathway. The reduced SDH level and fatty acid oxidation in Ifi27‐knockout brown fat results in impaired oxygen consumption and defective thermogenesis. Thus, IFI27 is a novel regulator of mitochondrial metabolism and thermogenesis.
Dual‐Pronged Attack: pH‐Driven Membrane‐Anchored NIR Dual‐Type Nano‐Photosensitizer Excites Immunogenic Pyroptosis and Sequester Immune Checkpoint for Enhanced Prostate Cancer Photo‐Immunotherapy
Authors: Wang He , He Zhangxin , Gao Yijian , Feng Dexiang , Wei Xuedong , Huang Yuhua , Hou Jianquan , Li Shengliang , Zhang Weijie 
Published: August 2023

AbstractProstate cancer (PCa) is a frustrating immunogenic “cold” tumor and generally receives unsatisfied immunotherapy outcomes in the clinic. Pyroptosis is an excellent immunogenic cell death form that can effectively activate the antitumor immune response, promote cytotoxic T‐lymphocyte infiltration, and convert tumors from “cold” to “hot.” However, the in vivo application of pyroptosis drugs is seriously limited, and the upregulation of tumor PD‐L1 caused by photo‐immunotherapy further promotes immune escape. Herein, a new nano‐photosensitizer (YBS‐BMS NPs‐RKC) with pH‐response integrating immunogenic pyroptosis induction and immune checkpoint blockade is developed. The pH‐responsive polymer equipped with the cell membrane anchoring peptide RKC is used as the carrier and further encapsulated with the near‐infrared‐activated semiconductor polymer photosensitizer YBS and a PD‐1/PD‐L1 complex small molecule inhibitor BMS‐202. The pH‐driven membrane‐anchoring and pyroptosis activation of YBS‐BMS NPs‐RKC is clearly demonstrated. In vitro and in vivo studies have shown that this dual‐pronged therapy stimulates a powerful antitumor immune response to suppress primary tumor progression and evokes long‐term immune memory to inhibit tumor relapse and metastasis. This work provides an effective self‐synergistic platform for PCa immunotherapy and a new idea for developing more biocompatible photo‐controlled pyroptosis inducers.
Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications
Authors: Feng Wenjun , Wang Zhengke 
Published: August 2023

AbstractHydrogels with tailor‐made swelling‐shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients and metabolites, as well as drug diffusion and release, hydrogels with high swelling capacity have been widely applicated in full‐thickness skin wound healing and tissue regeneration, and drug delivery. Nevertheless, in the fields of tissue adhesives and internal soft‐tissue wound healing, and bioelectronics, non‐swelling hydrogels play very important functions owing to their stable macroscopic dimension and physical performance in physiological environment. Moreover, the negative swelling behavior (i.e., shrinkage) of hydrogels can be exploited to drive noninvasive wound closure, and achieve resolution enhancement of hydrogel scaffolds. In addition, it can help push out the entrapped drugs, thus promote drug release. However, there still has not been a general review of the constructions and biomedical applications of hydrogels from the viewpoint of swelling‐shrinkable properties. Therefore, this review summarizes the tactics employed so far in tailoring the swelling‐shrinkable properties of hydrogels and their biomedical applications. And a relatively comprehensive understanding of the current progress and future challenge of the hydrogels with different swelling‐shrinkable features is provided for potential clinical translations.
Ground ivy (Glechoma hederacea) control with boron and iron in Kentucky bluegrass turf
Authors: Amgain Naba R. , Beck Leslie L. , Patton Aaron J. 
Published: August 2023

AbstractGround ivy (Glechoma hederacea L.) is a perennial broadleaf weed in the mint family (Lamiaceae) that is commonly found in turf in the temperate climates of the United States. Cultural practices that maintain dense turf are the best way to reduce weeds; however, cultural control methods alone cannot provide complete weed control. Herbicides are commonly used to control weeds in the turfgrass industry, but interest in alternative control methods is increasing. Applications of iron‐based products are an alternative chemical weed control option in turfgrass systems, but other micronutrients, such as boron, may also be a viable option. The objective of this study was to compare the efficacy of a chelated iron product as well as different boron‐based products for ground ivy control and also determine if these products injure Kentucky bluegrass (Poa pratensis L.). The products evaluated included borax, boric acid, Solubor (disodium octaborate tetrahydrate), and Fiesta (FeHEDTA) with a low and high rate tested for each. Ground ivy cover was reduced 77% or more from a single October application of all boron sources at the high rates and the high rate of Fiesta when evaluated 9 months later. The high rate of all boron‐containing products caused unacceptable turfgrass injury (<7) and reduced turf quality below acceptable levels (<6). No turfgrass injury or reduction in turf quality was observed in the Fiesta‐treated plots. These results indicate that applications of the micronutrient boron can be used to control ground ivy, but not without causing injury to Kentucky bluegrass.
Trends in long‐term outcomes of patients with HCV‐associated hepatocellular carcinoma after hepatectomy: A comparison before and after introduction of direct‐acting antivirus therapy
Authors: Munekage Fumiaki , Yoh Tomoaki , Ogiso Satoshi , Kato Takuya , Nam Nguyen Hai , Nagai Kazuyuki , Uchida Yoichiro , Ito Takashi , Ishii Takamichi , Hatano Etsuro 
Published: August 2023

AbstractBackgroundsThe success of direct‐acting antiviral (DAA) therapy provides a cure for patients chronically infected with hepatitis C virus (HCV); however, outcomes after hepatectomy for HCV‐associated hepatocellular carcinoma (HCC) before and after DAA introduction remain poorly studied.MethodsPatients who underwent R0/R1 hepatectomy for HCV‐associated HCC were retrospectively analyzed. Two time periods were defined: Pre‐DAA (2007–2011, December 2013 was defined as the end of follow‐up) and Post‐DAA groups (2014–2018, December 2020 was defined as the end of follow‐up). Propensity score matching (PSM) analyses were performed to highlight the effect of DAA therapy.ResultsA total of 155 patients with HCV‐associated HCC were included in this study (Pre‐DAA group, n = 103 and post‐DAA group, n = 52). In the Post‐DAA group, DAA therapy was performed in 26 patients (50.0%), and all of these patients achieved sustained virologic response (SVR) (preoperative SVR, n = 7; postoperative SVR, n = 19). There was no significant difference between the two groups regarding surgical settings and tumor pathology. There was no significant difference in the 5‐year overall survival (OS) rate (61.1% and 64.8%, pre‐ and post‐DAA group, respectively, p = 0.441); meanwhile, the 5‐year recurrence‐free survival (RFS) rate in the post‐DAA group was better than the pre‐DAA group (21.1% and 40.2%, p = 0.073) with a trend toward significance. After PSM except for the postoperative SVR status, there were no significant differences in OS (p = 0.586) and RFS (p = 0.888).ConclusionsThis study showed that survival outcomes were not changed in hepatectomized cases of HCV‐associated HCC before and after the introduction of DAA therapy.
Synergistic Effect of Allium‐like Ni9S8 & Cu7S4 Electrodeposited on Nickel Foam for Enhanced Water Splitting Activity
Authors: Mottakin M. , Selvanathan Vidhya , Ariful Islam Md. , Almohamadi Hamad , Alharthi Nabeel H. , Yoshimura Satoru , Akhtaruzzaman Md. 
Published: August 2023

AbstractThis study explores a water‐splitting activity using a biphasic electrodeposited electrode on nickel foam (NF). The *Ni9S8/Cu7S4/NF electrode with citric acid reduction exhibits superior OER (oxygen evolution reaction) and HER (hydrogen evolution reaction) performance with reduced overpotential and a steeper Tafel slope. The *Ni9S8/Cu7S4/NF electrode displays the ultra‐low overpotential value of 212 mV for OER and 109 mV for HER at the current density of 10 mA cm−2. The Tafel slope of 25.4 mV dec−1 for OER and 108 mV dec−1 for HER was found from that electrode. The maximum electrochemical surface area (ECSA), lowest series resistance and lowest charge transfer resistance are found in citric acid reduced electrode, showing increased electrical conductivity and quick charge transfer kinetics. Remarkably, the *Ni9S8/Cu7S4/NF electrode demonstrated excellent stability for 80 hours in pure water splitting and 20 hours in seawater splitting. The synergistic effect of using bimetallic (Cu&Ni) sulfide and enhanced electrical conductivity of the electrode are caused by reduction of metal sulfide into metallic species resulting in improved water splitting performance.
Facile and Cost‐effective Synthesis of CoP@N‐doped Carbon with High Catalytic Performance for Electrochemical Hydrogen Evolution Reaction
Authors: Yang Xinran , Shu Yasuhiro , Takada Ryuji , Taniguchi Yurika , Miyake Koji , Uchida Yoshiaki , Nishiyama Norikazu 
Published: August 2023

AbstractThe manufacture of efficient and low‐cost hydrogen evolution reaction (HER) catalysts is regarded as a critical solution to achieve carbon neutrality. Herein, we developed an economical method to synthesize a CoP‐anchored N‐doped carbon catalyst via one‐step pyrolysis using inexpensive starting materials (cobalt ion salt, phytic acid, and glycine). The size of the CoP nanoparticles was controlled by adjusting the Co/P ratio of the catalysts. Nanoscale CoP particles with adequate exposure to active sites were uniformly anchored on the surface of the conductive nitrogen‐doped carbon substrate, ensuring the rapid transfer of electrons and species. When Co/P=0.89, the as‐made catalyst exhibited outstanding HER activity, with an extraordinarily low overpotential of 202 mV at 10 mA cm−2 and long‐term stability.
Reaction of 4‐Bpin‐o‐Carborane with Ketones: Sequential Carbon Vertex Alkylation and B−B Bond Activation
Authors: Nie Zhen , Cheng Ruofei , Qiu Zaozao , Xie Zuowei 
Published: August 2023

AbstractDiboron compounds are important reagents in a series of transition metal catalyzed or metal‐free borylation reactions. We describe herein a unique reactivity of 4‐Bpin‐o‐carborane with ketones under basic conditions, leading to sequential cage carbon alkylation, B−B bond activation and unexpected O‐migration. The reaction was compatible with a good substrate scope including dialkyl or alkyl aryl ketones. The reaction mechanism is also proposed, involving cage CH deprotonation, nucleophilic attack of ketone, and O‐migration along with B−B bond cleavage.
Guillain–Barre syndrome complicating knee infectious arthritis
Authors: Khalayli Naram , Haj Ali Diaa , Kudsi Maysoun 
Published: August 2023

Key Clinical MessageGuillain–Barré syndrome (GBS) is a rare immune status, which affects the nerves, leading to muscle weakness and tingling, and, in some cases, paralysis. Our case showed that GBS may happen after knee infectious arthritis.
Vitamin B12 deficiency in an infant with neurological and hematological findings: A case report
Authors: Sharma Niraj Kumar , Bhattarai Madhur , Baral Kushal , Poudel Susmita , Hassan Nusaiba Farouk , Dhakal Tulsi Ram , Baral Rituraj 
Published: August 2023

Key Clinical MessageIt is important for pregnant and breastfeeding women who adhere to a strict vegetarian diet to take appropriate steps to avoid vitamin B12 deficiency in their infants.AbstractVitamin B12 deficiency is rare during infancy. The initial symptoms of this deficiency are subtle and may include irritability, failure to thrive with a decline in growth rate, apathy, anorexia, refusal of solid foods, megaloblastic anemia, and developmental regression. The case presented here involves an 8‐month‐old male infant who showed neurological symptoms such as decreased activity, increased drowsiness, and reduced interaction with parents, which were ultimately linked to a deficiency of cobalamin (vitamin B12). Early recognition of this condition is critical because it is reversible. Therefore, pregnant and lactating women who follow a strict vegetarian diet should take necessary measures to prevent vitamin B12 deficiency in infants.
Organocatalytic Enantioselective Intramolecular Michael Addition by In Situ Generated Aminoisobenzofulvenes: Construction of Spiro Quaternary Carbon Stereocenters
Authors: Midya Abhisek , Khalse Laxman Devidas , Ghorai Prasanta 
Published: August 2023

AbstractAn unprecedented enantioselective organocatalytic spirocyclization strategy is presented by in situ generation of aminoisobezofulvenes. The reaction sequence involves a reductive Michael/aldol‐condensation/Michael addition cascade by iminium‐enamine catalysis. The key success of this spirocyclization was the formation of intermediatory nucleophilic aminoisobenzofuvenes accountable for intramolecular Michael addition. Benzospirononanes featuring an all carbon qauternary spirocenter were obtained using proline‐derived amino‐organocatalyst in moderate to good yields and excellent diastereo‐ and enantioselectivities (up to >20 : 1 dr, and 99 % ee). Post‐methodological manipulation of benzospirononanes was also demonstrated.