bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study on reservoir architecture difference of extra-deep strike-slip fault zone in the Shunbei area, Tarim Basin
Authors: Kong Qiangfu , Hu Suyun , Wang Xiong , Liu Shuang 
Published: January 2023

Abstract
Shunbei reservoir is a typical extra-deep carbonate strike-slip fault-controlled reservoir. It has experienced multi-stage tectonic activities, and strong heterogeneity and anisotropy are present in the reservoir. Based on the reservoir cores, imaging logging, pressure build-up curves of typical wells, and dynamic analysis, the reservoir architecture difference between the S-1 and S-5 strike-slip fault zones in the Shunbei area is studied. The results show that the reservoir architecture of the S-5 fault zone is a fault-fracture system formed under the compressive stress environment, with small internal space, poor fluid flow capacity, small reservoir scale, and low energy. However, the reservoir architecture of the S-1 fault zone is the dilational space and caves bounded by fault planes formed under the tensile stress environment. The reservoir space could be categorized as the fault-fracture-cave system, which has large internal spaces and fluid flow capacity. Moreover, the reservoir is substantial in size and is highly energetic. This study has clarified the difference in reservoir architecture between the S-1 and S-5 fault zones and could be used as a classic case to predict the fault-reservoir relationship in the Shunbei area. It is of great significance for the exploration and development of the extra-deep carbonate strike-slip fault-controlled reservoir.
Striking a Balance Between eGFR Decline and LVEF Improvement in Asian Patients with Heart Failure Treated with Sacubitril/Valsartan
Authors: Wang Shih-Rong , Hsu Wan-Tseng 
Published: January 2023

Abstract
Background
After using sacubitril/valsartan, patients with heart failure exhibit different degrees of reverse cardiac remodeling. Those with unsatisfactory improvement may derive more harm than benefit because sacubitril/valsartan may impair renal function. This study investigated the critical factors related to changes in left ventricular ejection fraction (LVEF) and estimated glomerular filtration rate (eGFR) in patients to help clinicians balance the efficacy and safety of sacubitril/valsartan.
Methods
This retrospective study observed 333 patients with baseline LVEF ≤ 40% who had been prescribed sacubitril/valsartan for ≥ 30 days. We recorded their echocardiographic and laboratory data at 6-month intervals. The endpoint was death or heart transplantation.
Results
The median follow-up was 33.1 months. At 6 months, the mean increase in LVEF was 5.04%. Compared with the patients with a ∆LVEF of < 5% at 6 months, the patients with a ∆LVEF of ≥ 5% had a significantly higher survival rate, a shorter average heart failure duration, a lower rate of diuretic use at baseline, and better renal function at 6 months. The patients’ eGFR declined at an average rate of − 2.8 mL/min/1.73 m2 per year. Compared with the patients with a ∆eGFR of < 20% at 6 months, the patients with a ∆eGFR of ≥ 20% had a significantly lower survival rate, higher blood urea nitrogen and pulmonary pressure at baseline, and a higher average dose of concomitant diuretics at 6 months.
Conclusion
Although LVEF increasing ≥ 5% is associated with favorable health outcomes, eGFR decreasing ≥ 20% within the first 6 months of initiating sacubitril/valsartan is an indication against titration.
Long-term Efficacy of Endoscopic Balloon Dilatation in Patients with Small bowel Strictures Secondary to Crohn’s Disease
Authors: Liu Zelong , Sun Jiachen , Yang Hongsheng , Lin Huixian , Li Miao , Liu Zhongcheng , Kurban Mrigul , Gao Xiang , Zhang Ning , Guo Qin 
Published: January 2023

Abstract
Purpose Long-term Efficacy of Endoscopic Balloon Dilatation in Patients with Small bowel Strictures Secondary to Crohn’s Disease were poorly understood.
Methods We retrospectively collected and analyzed clinical data of CD patients with small intestinal strictures that underwent EBD treatment at three medical centers.
Results A total of 65 patients were included in the present study. During a median follow-up time of 869 days, the overall cumulative rate of repeat intervention after initial EBD was 35.4% (n = 23), with the majority (73.5%) occurring within 3 months. Only CRP level and diameter of dilatation balloon were found to be independently associated with repeat intervention, with HRs of 1.171 (95% CI: 1.040-1.319, p = 0.009) and 0.084 (95% CI: 0.014-0.508, p = 0.007), respectively. There was a tendency for anastomotic cases to have a lower risk of repeat intervention after initial EBD compared to non-anastomotic cases and ileocecal valve cases (p = 0.052). More importantly, the median intervention-free survival (IFS) of the anastomotic group was 1756.50 days (95% CI: 1588.03-1924.98 days), which was significantly longer than the non-anastomotic group (1093.91 days, 95% CI: 692.21-1495.61 days, p = 0.044) and the ileocecal valve group (1175.59 days, 95% CI: 786.96-1564.23 days, p = 0.029).
Conclusion In CD patients with small intestinal strictures treated with EBD, overall long-term efficacy was promising, while short-term failure and the requirement of repeat intervention occurred in a subset of individuals. Lower CRP levels and larger balloon sizes were found to be associated with a lower risk of repeat intervention.
Effects of selenium supplementation on N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis in rats
Authors: younesian Ommolbanin , Jafari Seyyed Mehdi , arabi Mehdi Sheikh , Naseh Hosein , Hosseinzadeh Sara , Joshaghani Hamidreza 
Published: January 2023

Abstract
Background: Esophageal cancer is one of the leading causes of cancer death and the seventh most prevalent cancer worldwide. Considering the positive association of high selenium with the prevalence of esophageal cancer in high-risk areas in the world, we have investigated the effect of high doses of selenium on gene expression in the esophagus of rats treated with N-nitrosomethylbenzylamine (NMBA).
Materials and methods: Esophageal squamous cell carcinoma (ESCC) was induced in Sprague Dawley male rats with NMBA (0.5 mg/kg BW, s.c, three times per week for 5 weeks). Rats in the treated groups were given 0.3, 1.5, and 3 mg/kg body weight sodium selenite for 20 weeks. After euthanizing the rats, esophageal tissue and blood was collected to assess the effects of high dose selenium. Pathological analysis was performed to diagnose preneoplastic lesion in the rat esophagus. Serum malondialdehyde and whole blood glutathione peroxidase activity was measured. Furthermore, the expression and concentration of the cyclin D1, cyclin E, KRAS, p53, NF-kB, TGF-β, and MGMT were analyzed and compared between groups.
Results: In the esophagus of rats treated with NMBA, increasing selenium levels significantly increased the mRNA levels of cyclin D1 and NF-κB p65.The concentrations of cyclin D1 was also significantly increased by high-dose selenium. Moreover, excess dietary selenium had no significant effect on serum MDA but significantly increased GPx activity.
Conclusion: The present study proved that high dose of inorganic selenium increases the mRNA levels of cyclin D1 and NF-κB p65 in the esophagus of rats treated with NMBA and may promote carcinogenesis by enhancing oxidative stress, inflammation, and cell proliferation.
The value of dual time point 18F-FDG PET/CT imaging in differentiating lymph node metastasis from reactive hyperplasia in bladder urothelial carcinoma
Authors: Zhou Xiang , Zhang Ruixue , Zhang Ruiyun , Hu Jiaxi , Sun Hong , Chen Ruohua , Wan Liangrong , Xia Jun , Huang Gang , Shi Kuangyu , Chen Haige , Liu Jianjun 
Published: January 2023

Abstract
Purpose
Our study explored the clinical value of dual time point FDG PET imaging for differentiating lymph node metastasis from lymph node reactive hyperplasia.
Methods
The study analyzed 250 lymph nodes from bladder cancer patients. All patients underwent 18F-FDG PET/CT delayed diuretic imaging. Metabolic parameters SUVmax, SUVmean, MTV, and related delay indices before and after PET delayed imaging were obtained. Relationships with outcomes were analyzed using nonparametric analysis and multivariate analysis. ROC curves and nomograms were drawn to predict lymph node metastasis.
Results
Delayed PET/CT imaging helps to detect more suspicious lymph nodes. If SUVmax = 2.0 or 2.5 was taken as cut-off, delayed imaging could increase the detection rate of metastatic lymph nodes by 4.1%, and 6.9%, respectively. Reactive hyperplasia lymph nodes were more likely to show increased lymph node-localized FDG uptake than metastatic lymph nodes on delayed FDG imaging. Metastatic lymph nodes were more likely to have whole, diffuse increased FDG uptake on delayed imaging. Short lymph node diameter, SUVmean, and DIMTV were three independent predictors for differentiating metastatic lymph nodes from reactive hyperplasia. Lymph node metastasis could be better differentiated from inflammatory hyperplasia ones by the combination of these three predictors. In high-risk patients, the probability of lymph node metastasis is as high as 97.6%.
Conclusions
Dual time point imaging is helpful to detect more suspicious lymph nodes. Some hyperplasic lymph nodes had certain image characteristics using delayed imaging. Short lymph node diameter, SUVmean, and DIMTV were three important parameters for predicting lymph node metastasis.
Polyamine-mediated mechanisms contribute to oxidative stress tolerance in Pseudomonas syringae.
Authors: Solmi Leandro , Rossi Franco R. , Romero Fernando Matías , Bach-Pages Marcel , Preston Gail M. , Ruiz Oscar A. , Gárriz Andrés 
Published: January 2023

Abstract
Bacterial phytopathogens thriving in the surface or the interior of plants may experience oxidative stress because of the activation of plant defense responses. Polyamines have been proposed to participate in the protection of bacteria against this stress, but the mechanisms behind their functions are mostly unclear. In this study, we sought to understand the effects of oxidative stress on the polyamine homeostasis of the plant pathogen Pseudomonas syringae and decipher the functions of these compounds in stress tolerance. We showed that bacteria react to H2O2 by raising the extracellular amount of the polyamine putrescine while the intracellular levels of this compound as well as the analogue spermidine remained unchanged. Consistent with this, supplementation of media with exogenous putrescine enhanced bacterial tolerance to H2O2. Deletion of arginine decarboxylase (speA) and ornithine decarboxylate (speC), prevented the synthesis of putrescine and augmented susceptibility to H2O2, whereas targeting spermidine synthesis alone through deletion of spermidine synthase (speE) increased the level of extracellular putrescine and enhanced H2O2 tolerance. Further research demonstrated that the increased tolerance of the ΔspeE mutant correlated both with increased expression of H2O2-degrading catalases and enhanced outer cell membrane stability. Thus, this work demonstrates previously unidentified links between the metabolism of polyamines and the defense against oxidative stress in bacteria.
Storm tracks and cyclogenesis over the Southern Ocean: An overview with the HadGEM3-GC3.1 model
Authors: de Souza Marcelo Rodrigues , Piva Everson Dal 
Published: January 2023

Abstract
Wide areas of the globe have their weather and climate strongly influenced by the action of extratropical cyclones. However, the characteristics of cyclones, their formation, displacement, and dissipation areas are dependent on the data and methodology employed. Here, we have evaluated the characteristics and spatial distribution of extratropical cyclones that had their genesis in the Southern Ocean (SO) in the present climate, based on data from the HadGEM3-GC3.1-MM (HG3) global model and the ERA5 reanalysis. Both in winter and in summer, cyclone tracks are spatially structured, forming a belt around the entire Antarctic continent, with greater concentration in the SO sector adjacent to the southern Pacific Ocean. Moderate and strong cyclones presented their trajectories in greater density in the regions of the Bellingshausen, Amundsen, and Somov seas, suggesting a correlation with the highest baroclinity in these regions. In both datasets, the maximum occurrence of cyclogenesis was located over the regions of the Somov Sea and the Antarctic Peninsula, making these regions very important in the general configuration of cyclones along the SO. Despite underestimating the total number of cyclones along the SO, the HG3 model showed a good ability to represent the main patterns of cyclonic activity around the Antarctic continent, as well as its average behavior. Knowing the characteristics and the behavior of extratropical cyclones in such an important area for global climate is essential for understanding their role in weather and future climate resulting from climate change.
Speciation and historical migration pattern interaction: examples from P. nigra and P. sylvestris phylogeography
Authors: Naydenov Krassimir , Naydenov Michel K. , Alexandrov Alexander , Gurov Todor , Gyuleva Veselka , Hinkov Georgi , Ivanovska Sofiya , Tsarev Anatoly , Nikolic Biljana , Goudiaby Venceslas , Carcaillet Christopher , Volosyanchuk Roman , Bojovic Srdjan , Vasilevski Kole , Matevski Vlado , Peruzzi Lorenzo , Christou Andreas Christou Andreas , Paitaridou Despina , Goia Irina , Kamary Salim , Gulcu Suleyman , Ture Cengiz , Bogunic Faruk 
Published: January 2023

Abstract
Here, from macrophylogeographic mtDNA empirical data, we propose a scenario for the evolution and speciation of two important forest trees, European black pine and Scotch pine, and their multiple subspecies and varieties. Molecular clock simulations revealed that INDEL variability in the Pinusmitochondrial genome is relatively old, i.e., from the Pliocene-Miocene epoch, and related to historical tectonic continental fluctuations rather than to climate change at a large geographic scale. For conservation and management biodiversity program recommendations, special attention is given to the relationships between different speciation models, historical migration patterns, and differences between peripheral and central populations. Species evolution involves the mixing of different speciation modes, and every speciation mode has different effects on different DNA types (e.g., mitochondrial vs. chloroplast vs. nuclear DNA). The misbalance between the contributions of different meta-population census sizes vs. effective population sizes to asymmetric migration patterns is the result of different genotypes (and subphylogenetic lines) responding to selection pressure and adaptive evolution. We propose initial minimal size of conservation unit (between 3 and 5 ha) from central and marginal natural area of distribution for both species in the dynamic management system for practical forest genetic diversity management. The proposed physical sizes was determine by the effective population size, effective radius of seed distribution data, forest density age dynamics, succession pattern, natural selection pressing and species biology [R-17].
Risk Stratification for Cardiovascular Disease Based on Prior Coronary Artery Disease, Cerebrovascular Disease and Diabetes Mellitus
Authors: Oe Momoko , Fujihara Kazuya , Yamada Mayuko Harada , Osawa Taeko , Kitazawa Masaru , Matsubayashi Yasuhiro , Sato Takaaki , Yaguchi Yuta , Iwanaga Midori , Yamada Takaho , Sone Hirohito 
Published: January 2023

Abstract
Background: Although the impact of a history of coronary artery disease (CAD), cerebrovascular disease (CVD) or both and diabetes mellites (DM) on cardiovascular disease is essential for cardiovascular risk management in clinical practice, little is known about such an impact. Therefore, we investigated the association of prior CAD, prior CVD, DM and their combinations with the risk of subsequent cardiovascular disease.
Methods: This historical cohort study included 342,033 participants aged 18-72 years followed for ≥5 years between 2008-2016. Eight groups were created according to whether they were with or without prior CAD, prior CVD and/or DM. DM was defined by fasting plasma glucose, HbA1c and antidiabetic drug prescription. Prior and subsequent CAD and CVD were identified by claims using ICD-10 codes, medical procedures and questionnaires. Cox regression models evaluated the risk of cardiovascular events.
Results: Median follow-up period was 6.4 years. Incidence of composite cardiovascular events due to CAD and/or CVD in CAD-/CVD-, CAD+/CVD-, CAD-/CVD+ and CAD+/CVD+ groups were 1.92, 6.94, 25.14 and 31.98 per 1,000 person-years in non-DM and 8.66, 18.04, 39.98 and 60.72 in DM, respectively. Hazard ratio of cardiovascular events compared to CAD-/CVD-/non-DM were 1.66 (95% CI 1.55-1.78) in CAD-/CVD-/DM and 1.84 (1.56-2.18) in CAD+/CVD-/non-DM. CVD+ increased the risk of cardiovascular events approximately 4- to 7- fold regardless of CAD+ or DM.
Conclusions:DM increase the risk of cardiovascular disease as high as a history of CAD, while prior CVD alone increased the risk of future cardiovascular disease without additional effects by DM.
Historical simulation of photovoltaic potential over China within the CORDEX-EA-II framework
Authors: Li Tongxin , Chen Jinqi , Zhao Ruonan , Tang Jianping , Zuo Dapeng , Tian Liqing , Zhang Zhongjie 
Published: January 2023

Abstract
The historical simulation of solar photovoltaic potential (PVpot) during 1989–2008 over China is evaluated against the ERA5 reanalysis, using the Weather Research and Forecasting (WRF) model and Regional Climate Model version 4 (RegCM4) within the framework of the Coordinated Regional Downscaling Experiment-East Asia second phase (CORDEX-EA-II). The impacts of Spectral Nudging technique and land surface model on the simulated PVpot are investigated as well. The results indicate that the observed PVpot is abundant over western China, which can reach up to 26% in summer. The WRF simulations significantly overestimate the PVpot over most areas of China, with the bias about 9% over southeastern China, while the utilization of Spectral Nudging method and CLM4 land surface model can greatly reduce the deviation. The RegCM4 simulations generate underestimation of PVpot over Northwest China, while overestimation over Southeast China. As for the interannual variation, the observed PVpot features an increase of 0.9%/decade over southeastern China. The WRF and RegCM4 simulations can reproduce the rising trend of PVpot, while the magnitude is much lower than ERA5. The WRF simulations can properly portray the characteristics of seasonal cycle of PVpot, with the peaks in May over entire China and most subregions, while RegCM4 exhibit poor skill in reproducing the intra-annual variation. Moreover, the simulated bias in the clear-sky solar radiation (RSDSCS), low-level cloud fraction and light rain during the daylight may contribute to the deficiency of PVpot.
Effects of chicken manure and chicken manure -derived biochar on the bioavailability and concentration of Lead (Pb) in two Brassica vegetables
Authors: Mulenga Moses , Mukumbuta Ikabongo , Uchida Prof. Yoshitaka , Chishala Ben 
Published: January 2023

Abstract
Lead (Pb) contamination has been widely reported in Kabwe town soils due to mining activities. The bioavailability and excessive amounts of Pb in soils are toxic to both plants and microorganisms. Manure and biochar have been reported to immobilize heavy metals in soil. This study, thus evaluated the effects of chicken manure and chicken manure-derived biochar on the bioavailability of Pb in the soil and its uptake by plants in polluted garden soils of Kabwe. Pots containing Pb contaminated soil with five treatments of manure and biochar in the following proportions: CT (un-amended polluted soil, control); 2% and 4% of CM (chicken manure); 2% of and 4% of CMB (chicken manure-derived biochar) were used in this study. The manure and biochar were applied as percentage of total mass of soil in the pot. Brassica napus (rape) was planted and grown in the soils under greenhouse conditions for nine weeks. After harvesting the rape, Brassica rapa (Chinese cabbage) was planted in the same pots and grown for eight weeks. The planting of Chinese cabbage was done to ascertain the residual effects of the amendments. Soil pH and bioavailable Pb was measured six times during the experiment and after the harvest, Pb concentration in plant tissues were determined using Atomic Absorption Spectroscopy (AAS - Z series 2010). Concentrations of bioavailable Pb were higher in the amended soils of 2% and 4% CM (18.90 ± 1.5; 21.18 ± 2.3 mg Pb/kg), 2% and 4% CMB (29.16 ± 2.4; 41.15 ± 2.6 mg Pb/kg) compared to CT (18.36 ± 1.6 mg Pb/kg). Despite higher bioavailable Pb in the manure and biochar amended soils; the concentration of Pb in both rape and Chinese cabbage tissues was lower than that in un-amended polluted soil (CT). Concentration of Pb in rape from 2% and 4% CM were less than detection limit, 2% and 4% CMB were 12.79 ± 2.49 mg Pb/kg and 8.4 ± 0.20 mg Pb/kg while concentration of Pb in rape from CT was 35.13 ± 13.72 mg Pb/kg. In Chinese cabbage, all amendments had Pb concentrations in plant tissues less than detection limit while the value in CT was 8.13 ± 0.97 mg Pb/kg. The experiment showed that, amendment application with increase in dose application results to reduced Pb uptake by the plants and concentration, despite increased Pb mobilization in soil. It is recommended that these amendments can be used for remediating Pb contaminated soils, as they seem to reduce Pb concentrations in plant tissues.
Effects of different doses of calcium gluconate combined with neostigmine on the recovery of neuromuscular blockade in the elderly
Authors: Hao Mengxiao , Yan Ming , Xing Rui , Zhang Ying , Mao Ye 
Published: January 2023

Abstract
Background

There is high incidence of postoperative residual curarization(PORC)in elderly patients. Ionised calcium plays a significant role in the neuromuscular junction. Objective to investigate the effect of using different doses of calcium gluconate on residual neuromuscular blockade༈NMB༉after laparoscopy in elderly patients, and also to observe its clinical safety and dose-effect relationship.

Methods

One hundred and eighty elderly patients who underwent elective laparoscopic surgery were randomly divided into four groups, the experimental group of 5 mg/kg, 10 mg/kg, 20 mg/kg calcium gluconate injection combined with neostigmine (C5 group, C10 group, C20 group) and the neostigmine group (N group), 45 cases in each group. At the end of the operation, when TOFc(train-of-four count) was ≥ 3, patients received 40 ug/kg neostigmine with 20 ug/kg atropine intravenously, while C5, C10, and C20 group received additional calcium gluconate 5 or 10 or 20 mg/kg. The time of TOFr (T4 /T1 ) ≥ 0.90 and the incidence of PORC at 5, 10, 15 and 20 minutes after neostigmine administration were observed in the four groups.

Results

The time of TOFr ≥ 0.90 was 11.50 (9.25,14.75) min in the control group, 7.50 (6.00,9.00) min in the C5 group, 9.50 (8.00,12.00) min in the C10 group and 10.00 (9.00,12.00) min in the C20 group (P＜0.001). The incidence of PORC after extubation was 27 (67.5%) in N group, 21 (52.5%) in C5 group 12 (30%) in C10 group and 7 (17.5%) in C20 group (P＜0.001). There were no differences between the four groups with respect to the incidence of PORC at 5 and 15min after administration of neostigmine.

Conclusions

Calcium gluconate can be safely used for promoting early postoperative NMB recovery of cis-atracurium in elderly patients, and the recovery process was more stable in the C20 group.