bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cataract with linezolid-induced toxic optic neuropathy: Case report and mini review
Authors: Han Dong , Wang Jing , Tang Kaili , Zhao Zhenbo , Ding Yuxi , Zhang Jinsong 
Published: March 2023

Abstract
We report a rare case of cataract with linezolid-induced toxic optic neuropathy that resulted in poor visual improvement after cataract surgery. The preoperative diagnosis of toxic optic neuropathy was unclear because the patient had cataract and concealed the 20-year history of pulmonary tuberculosis and 1-year of linezolid treatment. Postoperatively, an obvious improvement in visual acuity was not noted. On the basis of previous medical history, clinical manifestations, and medical examinations, the patient was diagnosed with optic neuropathy that probably resulted from prolonged linezolid treatment. In accordance with the physicians’ advice, the patient discontinued the linezolid tablet (0.6 g/day) and started taking beidaquiline fumarate tablet (0.4 g/day). Neuronutrition and circulatory improvement therapies were also provided. After 1 month of follow-up, the patient’s overall vision, color vision, and visual field improved significantly. This case report aims to help people understand linezolid-induced optic neurotoxicity and its related clinical characteristics and to provide ophthalmologists additional insights for the clinical diagnosis and treatment of this condition. Furthermore, assessing the risk of optic neuropathy is necessary for high-risk patients before cataract surgery to establish an appropriate risk plan and provide targeted treatment.
Raising predatory babies: development from fertilization to sexual maturity of the hoplonemertean Emplectonema viride (Nemertea)
Authors: Mendes Cecili B. , von Dassow George , Andrade Sónia C. S. , Maslakova Svetlana 
Published: March 2023

Abstract
Marine ribbon worms from the class Hoplonemertea were presumed to have lecithotrophic development until the recent discovery of predatory larvae in several species, including Emplectonema viride Stimpson, 1857 — a common NE Pacific intertidal nemertean. Here we report the complete life cycle of E. viride from fertilization to sexual maturity, which takes about 9.5 months. Predatory larvae of this species were successfully raised to metamorphosis on a diet of planktonic crustaceans, including barnacle nauplii and cyprids, as well as an occasional calanoid copepod. The larvae swam and grew for 3–4 months in lab culture with abundant food, before settling as juveniles and starting to feed upon adult barnacles. Settlement was accompanied by a subtle but definite metamorphosis, which includes shortening of epidermal cilia, loss of the caudal ciliary cirrus, and behavioral changes. Larvae were positively phototactic, whereas juveniles were negatively phototactic. Pelagic larval duration of several months provides abundant opportunities for dispersal, and likely results in high genetic connectivity between populations. Population genetic studies on other hoplonemertean species reveal higher-than-expected gene flow, suggesting that planktotrophic macrophagy (predatory larvae), such as we describe here for E. viride, may be widespread within the class.
Human Papillomavirus vaccination practice and its associated factors among secondary school female students in Nekemte town, Oromia region, Ethiopia, 2022
Authors: Abera Mitiku , Kebede Awoke , Ayalew Tiliksew , Mengesha Tadele 
Published: March 2023

Abstract
Background: Human papillomavirus vaccination is a well-known global strategy for the prevention of cervical cancer. However, uptake of the vaccine varies between regions and countries of the world due to several discouraging factors. Although adolescents are at risk for cervical cancer, there are limited studies measuring vaccination practice of female adolescents in the study area.
Objective: To assess human papillomavirus vaccination practice and its associated factors among secondary school female students in Nekemte town, Oromia region, Ethiopia, 2022
Methods and materials: A school-based cross-sectional study was conducted from May 13 to June 13, 2022 among female students in secondary schools in Nekemte town, Oromia region, Ethiopia. A total of 423 samples were selected using a computer generated simple random sampling technique. Data was collected using a structured and self-administered questionnaire. The study participants were informed of the need for this study. Epi Data version 4.6 was used for data entry and statistical packaging for social science (version 26) for data analysis. Binary logistic regression was calculated using the odds ratio with a 95% confidence interval. Variables with a p-value < 0.25 in the bi-variable analysis were taken into multi-variable analysis. Finally, variables with a p-value < 0.05 were declared as statistically significant.
Result: The current study revealed that the magnitude of human papillomavirus vaccination practice was 52% (CI; 46.8-56.6) in the study area. Factors significantly associated with human papillomavirus vaccination practice were: having good knowledge of human papillomavirus and its vaccine (AOR = 5.79, CI; 3.34 - 10.03), having positive attitude towards human papillomavirus vaccination (AOR = 8.36, CI; 4.67 - 14.93), higher maternal education level (college and above) (AOR = 5.47, CI; 1.68 - 17.82) and urban residence (AOR = 4.12, CI; 1.86 - 9.31).
Conclusion and Recommendation: in this study, the magnitude of human papillomavirus vaccination practice was low. Therefore, we recommend the Ethiopian Ministry of Health conduct mass HPV vaccinations and community sensitization to increase awareness and behavioral change education is necessary to enhance optimum coverage of the vaccine.
Defining the filarial N-glycoproteome by glycosite mapping in the human parasitic nematode Brugia malayi
Authors: Mersha Fana B. , McClung Colleen M. , Chen Minyong , Ruse Cristian I. , Foster Jeremy M. 
Published: March 2023

Abstract

N-linked glycosylation is a critical post translational modification of eukaryotic proteins. N-linked glycans are present on surface and secreted filarial proteins that play a role in host parasite interactions. Examples of glycosylated Brugia malayi proteins have been previously identified but there has not been a systematic study of the N-linked glycoproteome of this or any other filarial parasite. In this study, we applied an enhanced N-glyco FASP protocol using an engineered carbohydrate-binding protein, Fbs1, to enrich N-glycosylated peptides for analysis by LC-MS/MS. We then mapped the N-glycosites on proteins from three host stages of the parasite: adult female, adult male and microfilariae. Fbs1 enrichment of N-glycosylated peptides enhanced the identification of N-glycosites. Our data identified 582 N-linked glycoproteins with 1273 N-glycosites. Gene ontology and cell localization prediction of the identified N-glycoproteins indicated that they were mostly membrane and extracellular proteins. Comparing results from adult female worms, adult male worms, and microfilariae, we find variability in N-glycosylation at the protein level as well as at the individual N-glycosite level. These variations are highlighted in cuticle N-glycoproteins and adult worm restricted N-glycoproteins as examples of proteins at the host parasite interface that are well positioned as potential therapeutic targets or biomarkers.
First report of Citrus Tristeza virus in Diaphorina citri of different nymphal and adult stages or different sexes collected from field
Authors: Zhang Jingtian , Xiao Yuxin , Chen Longtong , Cui Xiaoqing , Deng Xiaoling , Xu Meirong 
Published: March 2023

Abstract
Objective: Diaphorina citri (D. citri) is the vector of “Candidatus Liberibacter asiaticus” (CLas), the most prevalent bacterial species causing citrus Huanglongbing. We recently reported for the first time that the D. citri could acquire the Citrus tristeza virus (CTV), a vitrus previously reported vectored by different aphids, and persist it for at least 15 days. In this study, the CTV and CLas profiles in different organs, development stages, and sexes of D. citri were analyzed.
Results: The 3rd instar nymph D. citri is with relatively higher CTV titer, high CTV-positive rates and CLas-positive rates. No significant difference between sexes in their carried CTV and CLas titer. CTV titers in the midguts of adult D. citri were significantly higher than those in salivary glands.
Conclusion: Although there is no significant differences between nymphs and adults on the CTV titers, the 3rd instar nymph D. citri is efficient in CTV and CLas acquisition.
Vacuum brazing of TZM alloy and graphite with Ti-35Ni alloy: Microstructure, properties, and mechanism
Authors: Song Yanyu , Zhu Haitao , Zhao Kehan , Chen Naibin , Liu Duo , Hu Shengpeng , Song Xiaoguo 
Published: March 2023

Abstract
Reliable TZM/graphite brazed joint was obtained in a vacuum using Ti-35Ni alloy in the present work. The interfacial microstructure, shear strength, and fracture characteristics of the brazed joints were all analyzed. In addition, the formation mechanism of the brazed joint was investigated in detail. The typical interfacial microstructure of the TZM/graphite joint brazed at 1200°C for 10 min was TZM/Ti(s,s)/TiNi+Ti2Ni/TiC/graphite. The width of the brazing seam increased and then decreased with the elevated temperature, while the thickness of the TiC layer gradually increased. In addition, the amount of Ti2Ni phase in the brazing seam decreased above 1200°C and eventually disappeared at 1220°C. An optimal shear strength of 14.5 MPa was achieved for the TZM/graphite joint at a brazing temperature of 1300°C for 10 min. At the optimum brazing temperature, the fracture path of the joint started in the TiC layer and then extended to the interior of the graphite substrate.
Mental Health Knowledge and Social Distancing Among Clinical Nurses: the Mediating Role of Stigma in Mental Illness/a Cross-sectional Study
Authors: wang weiwei , zhao ting , chen wei , cui huixia , liu rui 
Published: March 2023

Abstract
Background: The stigma of mental illness has a negative impact on nurses and their patients. Most current research explores the impact of single factors on stigma and does not explore the relationship between knowledge, social distance and stigma among clinical nurses.
Methods: Based on the knowledge, attitude, belief and practice model, to study the current status of mental illness stigma among caregivers and to analyse the relationship between mental illness stigma, social distancing, and mental health knowledge among nurses. A random sample was used to study 628 nurses.The study was conducted in five hospitals in Jinzhou and Dalian. A general information questionnaire, Scale for Assessing the Stigma of Mental Illness in Nursing, the Social Distance Scale and the Mental Health and Mental Health Knowledge Questionnaire were included. With mental health knowledge as the independent variable (X), social distance of mental illness as the dependent variable(Y), and stigma of mental illness among clinical nurses as the mediating variable (M), the mediation effect was analyzed.
Results: The Scale for Assessing the Stigma of Mental Illness in Nursing score was 58.96±9.38 points, the violence/dangerousness dimension score was 22.68±5.71 points, the disability dimension score was 14.64±3.54 points, the irresponsibility and lack of competence dimension score was 21.64±3.83 points, and the mean scores of psychiatric and general nurses were 58.39±8.90 and 56.97±10.36 points, respectively. The stigma of mental illness, social distance and mental health knowledge of nurses were positively correlated (p<0.01). Stigma indirectly affected the social distance between the clinical nurses and mental health patients (β=0.016, P=0.000), and to some extent, stigma influenced the effect of mental health knowledge on social distancing among clinical nurses (β=0.123, P=0.008).
Conclusions: The stigma attached to mental illness by the clinical nurses was moderate and the main mediating effect between mental health knowledge and social distancing. Clinical nurses should integrate disciplinary knowledge, increase the mastery of knowledge, enrich the multidisciplinary nursing experience, reduce stigma through multiple channels, and provide a quality nursing environment for the recovery and prognosis of mental health patients.
Quantum Otto heat engine with Pöschl-Tellerpotential in contact with coherent thermal bath
Authors: Abasabadi Sajjad Hashemi , Mirafzali Sayyed Yahya , Baghshahi Hamid Reza 
Published: March 2023

Abstract
Work and efficiency of quantum Otto heat engines (QOHEs) can increase by using non-thermal baths or by inhomogeneousscaling of energy levels of the working substance. Given these points, at first, we construct the coherent thermal state for atrigonometric Pöschl-Teller (PT) potential. Then using a particle in this potential, which has unequally spaced energy levels,as a working substance, we investigate the work extraction and the efficiency of QOHEs that operates between cold and hotcoherent thermal baths. The results show that changing the PT potential parameters in the adiabatic processes of QOHE,which causes an inhomogeneous shift in energy levels or/and make use of the hot coherent thermal bath, improve workextraction and efficiency of QOHE relative to the classical counterpart.
Measuring light pollution in the night sky – from technology demonstrator to monitoring system
Authors: Karpińska Dominika , Kunz Mieczysław 
Published: March 2023

AbstractPollution of the night sky by artificial light has now become an important element of the modern city landscape. The decline in the quality of the sky observed at night in urban areas has already been noticed even by residents unaware of its origin. A starry sky is nowadays not easy to observe even in places far from large conurbations or smaller cities. More and more places are losing access to the previously natural privilege of observing the dark sky, and their inhabitants are thus systematically exposed to all the direct and indirect negative effects of this phenomenon. Monitoring the brightness of the night sky is gaining interest from a growing number of interdisciplinary research groups being established around the world, including Poland. In Toruń, the first measurements of the magnitude of this phenomenon, together with the determination of its spatial scale, were started using handheld devices in 2017. In the following years, efforts were made to improve the data acquisition process by creating a prototype – a technology demonstrator and, consequently, a commercial version of an automatic device measuring the surface brightness of the night sky. This paper presents the stages of the project aimed at developing a light pollution monitoring system, which has been consistently implemented in Toruń. The most important component of this system is a measuring device of our own design and construction. The monitoring system designed and operating in Toruń, starting in 2019, is being further developed with new components and monitoring (measurement) sites being systematically added, making the city’s observation network increasingly dense. The devices built using the LoRa standard for wireless data exchange implement the concept of the Internet of Things, fitting in with the objectives of a smart city.
Can transbronchial lung cryobiopsy benefit adaptive treatment strategies in connective tissue disease-associated interstitial lung disease?
Authors: Yamakawa Hideaki , Takemura Tamiko , Sato Shintaro , Takatsuka Makiko , Ohta Hiroki , Nishizawa Tomotaka , Oba Tomohiro , Kawabe Rie , Akasaka Keiichi , Horikoshi Masanobu , Amano Masako , Kuwano Kazuyoshi , Matsushima Hidekazu 
Published: March 2023

Abstract
Background
Some patients with connective tissue disease (CTD)-associated interstitial lung disease (ILD) progress to pulmonary fibrosis over their disease course despite initial improvement, potentially indicating a poor prognosis. Transbronchial lung cryobiopsy (TBLC) is a new bioptic approach used in diffuse parenchymal lung diseases. This study of CTD-ILD assessed the utility of TBLC in determining therapeutic decision-making strategies.
Methods
We analyzed medical records of 31 consecutive CTD-ILD patients who underwent TBLC focusing on radio-pathological correlation and disease course. A TBLC-based usual interstitial pneumonia (UIP) score was used that assessed three morphologic descriptors: i) patchy fibrosis, ⅱ) fibroblastic foci, and ⅲ) honeycombing.
Results
Among the patients with CTD-ILD, 3 had rheumatoid arthritis, 2 systemic sclerosis, 5 polymyositis/dermatomyositis, 8 anti-synthetase syndrome, 6 Sjögren’s syndrome, and 5 had microscopic polyangiitis. Pulmonary function test results showed a mean %FVC of 82.4% and %DLCO of 67.7%. Among the 10 CTD patients and TBLC-proven pathological UIP, 3 patients had prominent inflammatory cells in addition to a framework of UIP, and pulmonary function of most patients improved with anti-inflammatory agents. Six (40%) of 15 patients with TBLC-based UIP score ≥ 1 had a progressive disease course during follow-up, of whom 4 patients received anti-fibrotic agents.
Conclusions
TBLC in patients with CTD-ILD can help determine an appropriate medication strategy, particularly when UIP-like lesions are present. TBLC may be useful when judging which agents to prioritize, anti-inflammatory or anti-fibrotic, is difficult. Moreover, additional information from TBLC may be beneficial when considering early intervention with anti-fibrotic agents in clinical practice.
Development and external validation of a nomogram for predicting the survival outcomes of patients with Ki-67 positive grade 4 diffuse gliomas
Authors: Liu Hui , Lun Peng , Zhao Jihu , Wang Fuxu , Cai Xuechang , Sun Peng 
Published: March 2023

Abstract
Background
Grade 4 diffuse gliomas is a highly malignant tumor with considerable health implications. Studies have investigated the immunohistochemical molecules associated with glioblastoma development. However, grade 4 diffuse gliomas in Ki-67 positive patients have not been conclusively investigated.
Methods
We retrospectively extracted data for 146 patients with Ki-67 positive grade 4 diffuse gliomas at the affiliated hospital of Qingdao University between 2020 and 2021. The data were analyzed using the R software. Statistically significant indicators were identified by COX regression analysis and used to establish the Nomogram. The nomogram was corrected by C-index, area under the curve (AUC), calibration curve and decision curve analyses (DCA). Finally, the model was externally validated using the Chinese Glioma Genome Atlas (CGGA) database. The experiment was approved by the Medical Ethics Committee of the Affiliated Hospital of Qingdao University. All methods were performed in accordance with relevant guidelines and regulations. The authors of this experiment promise that informed consent of all subjects and/or their legal guardians has been obtained for this research.
Results
Age, treatment and IDH were found to be significant. The models’ C-index was 0.743 while the area under the curve (AUC) value of the time-dependent ROC curve at 3- and 6-months were 0.832 and 0.829, respectively. These findings imply a good discriminatory ability. Finally, a nomogram was constructed and validated using validation and DCA curves.
Conclusion
Three risk factors (age, treatment and IDH) were identified to be independent prognostic factors in Ki-67 positive grade 4 diffuse gliomas patients. The model can be used to accurately assess the disease-specific survival rates of these patients and inform on treatment options.
Optimization algorithms in security and privacy-preserving data disturbance for collaborative edge computing social IoT deep learning architectures
Authors: Boopathi Mythili , Gupta Sachin , N Mohammed Zabeeulla A , GUPTA RUPAL , Vekriya Vipul , Pandey Arvind Kumar 
Published: March 2023

Abstract
Edge computing (EC) has been viewed as a viable option for addressing cloud computing's shortcomings in supporting Internet-of-Things (IoT) applications as an innovative strategy. However, edge-assisted IoT security requires to be better guaranteed due to the network's instability and increase in attack surfaces. Practice of safeguarding a given network from threats that could compromise its availability is referred to as network security. In addition, we can add that network security must address issues such as unauthorized access to network-accessible resources and even their misuse. This study proposes a novel approach to improving edge computing-based data privacy through secure data transmission and deep learning-based optimization with Internet of Things. Edge network privacy preservation is accomplished through collaborative architecture and hybrid federated sever-based stochastic vector networks. The trust based multiple encryption algorithm is used to secure the transmission of the data after it has been optimized using firefly grey optimization. Throughput, network security analysis, PDR, latency, and energy consumption were all examined as part of the experimental analysis for network data privacy and optimization.
The Association Between Bisphenol A Exposure And The Risk Of Congenital Heart Defects Occurrence In Offspring: A Multi-hospital Case-control Study in China
Authors: Guo Yixiong , Yu Ping , Zhu Jun , Deng Ying , Li Nana , Liu Zhen 
Published: March 2023

Abstract
Background
To examine the association between Bisphenol A (BPA) levels of maternal serum during pregnancy and the occurrence of infant congenital heart defects (CHDs).
Method
A hospital-based case-control study was performed with samples collected from 2010 to 2014. BPA levels in maternal serum were obtained by Enzyme-Linked Immunosorbent Assay (ELISA). Data from medical records with infant congenital heart defects were collected. Logistic regression analysis was employed to examine the association between maternal BPA exposure and fetal CHD adjusted for confounders (including maternal age and pre-pregnancy body mass index, etc.).
Results
In total, 524 pregnant women were included in this study. Median (inter-quartile range) BPA levels of maternal serum from the control group and CHD group were 4.6868 (1.6555–8.8338) ng/ml and 4.4641 (1.5902–8.7714) ng/ml, respectively. No association was detected between increased maternal serum BPA concentration and various CHDs phenotype groups, total cases group (aOR 1.003, 95% CI 0.983–1.023), cases having CHDs only (aOR 1.003, 95% CI 0.980–1.026), cases suffering from CHD as well as other defects (aOR 1.002, 95% CI 0.974–1.032), single-subtype CHD (aOR 1.007, 95% CI 0.978–1.037), multiple-subtypes CHDs (aOR 1.002, 95% CI 0.980–1.025).
Conclusion
Maternal BPA exposure is not significantly correlated with the risk of fetal CHD.
Removal of Cadmium and Arsenic from Water through Biomineralization
Authors: Kaur Manjot , Sidhu Navneet , Reddy M. Sudhakara 
Published: March 2023

Abstract
Due to anthropogenic activities, heavy metals such as cadmium (Cd) and arsenic (As) are one of the most toxic xenobiotics contaminating water, thus, affecting the human health and environment. The objective of the present investigation was to study the effect of ureolytic bacteria Bacillus paramycoides – MSR1 for the bioremediation of Cd, and As from contaminated water. The B. paramycoides showed high resistance to heavy metals of Cadmium and Arsenic with minimum inhibitory concentration of 12.84 µM and 48.54 µM, respectively. The urease activity and calcium carbonate (CaCO3) precipitation was evaluated by bacteria in the presence of different concentrations of Cd and As. High removal rates for cadmium (93.13%) and arsenic (94.25%) were observed after a period of 168 hours. Microstructural analysis revealed formation of calcium carbonate in the form of calcite by the bacteria and EDS further confirmed the presence of heavy metal ions in the calcium carbonate precipitates. The results demonstate removal of Cadmium and Arsenic by microbially induced calcium carbonate precipitation to be promising technique for decontamination of water.