bluuebunny/crossref_metadata_2025_split huggingface dataset:
Religions de l’Inde : études shivaïtes
Authors: Törzsök Judit 
Published: July 2023

Dans le cadre du cours de master, nous avons poursuivi la lecture du « Cœur de la reconnaissance » (Pratyabhijñāhṛdaya) de Kṣemarāja (auteur cachemirien du début du xie siècle), en lisant le texte accompagné de nombreuses notes marginales dans un manuscrit Śāradā. Pour notre séminaire, nous avons continué à analyser les prescriptions śākta du Siddhayogeśvarīmata ou « Enseignements des yoginīs perfectionnées » (du viie siècle environ) et à lire le « Joyau magique de la geste de Śiva » (Haracaritacintāmaṇi) de Jayadratha (auteur cachemirien du début du xiiie siècle), dont le chapitre 30 résume la religion śivaïte laïque (laukika) selon le Śivadharmottara (« La religion de Śiva, partie 2 »).
Une controverse entre païens et chrétiens sur le culte des martyrs et la vénération des tombeaux : étude de Cyrille d’Alexandrie, Contre Julien X, 11-21
Authors: Boulnois Marie-Odile 
Published: July 2023

Le séminaire a porté sur la deuxième partie du livre X du Contre Julien de Cyrille d’Alexandrie qui réfute les fragments 81 et 82 de l’ouvrage de l’empereur Julien centrés sur la critique du culte des martyrs et de la vénération des tombeaux. Dans la construction du premier livre du Contre les Galiléens, ces objections sont destinées à prouver que les chrétiens ont atteint un paroxysme après une série d’apostasies successives.
Strafbaarstelling van doxing: ontmaskeren en intimideren
Authors: Berndsen M. (Michael) 
Published: July 2023

Strafbaarstelling van doxing: ontmaskeren en intimideren. Over het wetsvoorstel Strafbaarstelling gebruik persoonsgegevens voor intimiderende doeleinden
Het wetsvoorstel Strafbaarstelling gebruik persoonsgegevens voor intimiderende doeleinden – kort gezegd: het wetsvoorstel doxing – stelt het strafbaar om persoonsgegevens van een ander te verzamelen of verspreiden met het doel om die persoon vrees aan te jagen of ernstige overlast of hinder aan te doen. Dit artikel verkent de achtergrond en reikwijdte van de voorgestelde bepaling en signaleert enkele knelpunten en geeft – waar mogelijk – een aanzet tot verbetering en verduidelijking.
Als ik dood ben…
Authors: Buisman S.S. (Sanne) 
Published: July 2023

Als ik dood ben… Over een zelfstandige strafbaarstelling van necrofilie
In 2023 constateerde drie zusters dat seksuele handelingen waren verricht met het overleden lichaam van hun moeder. De gebeurtenissen hadden grote impact op de nagedachtenis van de overleden dierbare. Toch kon de dader niet worden gestraft, omdat in Nederland necrofilie (nog) niet zelfstandig strafbaar is. In het licht van het thema ‘wildgroei aan strafbaarstellingen’, zal in deze bijdrage nader worden ingegaan op de vraag waarom necrofilie zelfstandige strafbaarstelling legitimeert en rechtvaardigt en hoe een nieuwe strafbepaling zou moeten worden samengesteld.
Aplikasi Database Untuk Mengelola Persediaan Barang di Toko Baju D’Clothing Menggunakan Pendekatan Entity Relationship Chart
Authors: Zerlinda Frea Marva , Zulfa Zaidan Muhammad , Fisrawati  , Hadias Safitri Novia , Fathan Nabil Al-Badi Muhammad 
Published: July 2023

D’Clothing store is one of the clothing stores located in Bogor that provides many choices for various ages, both women and men. Based on the interviews, D'Clothing store had some troubles in product management, starting from inventory data, suppliers data, sales data, et cetera. To overcome this problem, a new system is needed to facilitate management by utilizing technological products, which as creating a database. The output of this database is to make a form containing the name, stock, color, size, code, and price of the goods. In its preparation, there are several obstacles such as data being out of sync between the main table and other tables when building a relationship. After being analyzed, this issue happens due to the wrong placement of the primary key and records between tables. Another error is found in the placement of the formula when building the Query design. Therefore, it takes precision and logic to find a way out.
Growth of Private Equity and Hospital Consolidation in Primary Care and Price Implications
Authors: Singh Yashaswini , Radhakrishnan Nandita , Adler Loren , Whaley Christopher 
Published: January 2025

ImportanceConsolidation of physician practices by hospitals and private equity (PE) firms has increased rapidly. This trend is of particular importance within primary care. Despite its significance, there is no systematic evidence on the emerging trends in ownership affiliation of primary care physicians (PCPs) and its association with prices paid for physician services.ObjectiveTo describe trends in hospital affiliation and PE affiliation in primary care and examine variation in negotiated prices paid by commercial insurers to hospital-affiliated, PE-affiliated, and independent PCPs.Design, Setting, and ParticipantsData from PitchBook and IQVIA were used to examine hospital and PE affiliation PCPs. PCPs and their affiliations were linked to novel cross-sectional Transparency in Coverage data. A total of 226.6 million negotiated prices were analyzed for evaluation and management office visits (Current Procedural Terminology codes 99202 to 99205 and 99212 to 99215) across 4 national insurers (Aetna, Blue Cross Blue Shield, Cigna, and United Healthcare). Linear regressions were used to examine the association between hospital-affiliated, PE-affiliated, and independent PCPs and cross-sectional prices paid for physician services, with fixed effects for service, state, and insurers. Data were collected from January to June 2024, and data were analyzed from July to October 2024.Main Outcomes and MeasuresThe proportion of PCPs that are affiliated with hospitals and PE from 2009 to 2022. Using cross-sectional data from 2022, negotiated prices paid to physicians (physician professional fee) for office visits.ResultsA total of 198 097 PCPs were analyzed. PCPs affiliated with hospitals increased from 25.2% (28 216 of 111 793) in 2009 to 47.9% in 2022 (82 890 of 172 964). Over the same period, 1.5% (2483 of 172 964) of PCPs became affiliated with PE firms. Relative to independent PCPs, negotiated prices for office visits were $14.91 (95% CI, 8.92-27.64) or 10.7% (95% CI, 10.1-11.4) higher for hospital-affiliated PCPs (P &amp;lt; .001) and $9.56 (95% CI, 2.24-14.55) or 7.8% (95% CI, 4.7-10.8) higher for PE-affiliated PCPs (P &amp;lt; .001).Conclusions and RelevanceIn this cross-sectional study, nearly one-half of all PCPs were affiliated with hospitals, while PE-affiliated PCPs were growing and concentrated in certain regional markets. Relative to PCPs in independent settings, hospital-affiliated PCPs and PE-affiliated PCPs had higher prices for the same services.
Health Care Utilization and Costs for Older Adults Aging Into Medicare After the Affordable Care Act
Authors: Tipirneni Renuka , Roberts Eric T. , Levy Helen G. , Stefanescu Andrei R. , Langa Kenneth M. , Zivin Kara , Maust Donovan T. , Ayanian John Z. 
Published: January 2025

ImportanceThe Affordable Care Act (ACA) expanded Medicaid and Marketplace insurance to nonelderly adults in 2014, but whether these policies improved outcomes later in life is unknown.ObjectiveTo examine whether exposure to ACA expansions during middle age (50-64 years) was associated with changes in health, utilization, and spending after these adults entered Medicare at 65 years of age.Design, Setting, and ParticipantsThis serial analysis of the Health and Retirement Study cohort linked to Medicare enrollment and claims data from January 1, 2010, to December 31, 2018. Adults aged 65 to 68 years entering Medicare after the ACA (exposed to ACA expansions during middle age) were compared with adults entering Medicare before the ACA (4452 person-years). Interrupted time series analyses were used to assess overall changes associated with exposure to ACA expansions and difference-in-differences analyses to isolate changes associated with Medicaid expansion among low-income adults (incomes ≤400% of the federal poverty level for any ACA coverage and ≤138% for Medicaid expansion coverage). Data were analyzed from March 1, 2023, to May 1, 2024.ExposuresACA coverage expansion overall in 2014 and Medicaid expansion as of 2018.Main Outcomes and MeasuresHealth (self-reported overall, activities of daily living [ADL], instrumental ADL, and depressive symptoms), utilization (outpatient visits, emergency department visits, and hospital admission), and costs (self-reported out-of-pocket and Medicare costs).ResultsAmong the analytic sample of 2782 participants (mean age, 66.4 [95% CI, 66.3-66.5] years), a weighted 59.1% (95% CI, 55.3%-62.7%) were female. In interrupted time series analyses, reductions across cohorts were found in use of chronic disease medications (−5.0 [95% CI, −9.8 to −0.3] percentage points), hospitalizations per year (−0.2 [95% CI, −0.4 to −0.03]), and out-of-pocket costs (−$417 [95% CI, −$694 to −$139]) but no significant changes across cohorts in health status, outpatient or emergency visits, or Medicare costs. In difference-in-differences analyses relative to nonexpansion states, greater reductions were found in the number of ADL limitations (−0.4 [95% CI, −0.8 to −0.02]) and lesser reductions in out-of-pocket costs ($900 [95% CI, $275-$1526]) in Medicaid expansion states but otherwise similar changes in other outcomes.Conclusions and RelevanceThis study found modest evidence of reductions in out-of-pocket costs and improvements in health among adults entering Medicare after the ACA. Insurance coverage and financial assistance should be preserved and enhanced to improve health and health care access among vulnerable older adults.
Estimated Burden of Metabolic Dysfunction–Associated Steatotic Liver Disease in US Adults, 2020 to 2050
Authors: Le Phuc , Tatar Moosa , Dasarathy Srinivasan , Alkhouri Naim , Herman William H. , Taksler Glen B. , Deshpande Abhishek , Ye Wen , Adekunle Olajide A. , McCullough Arthur , Rothberg Michael B. 
Published: January 2025

ImportanceMetabolic dysfunction–associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease and is projected to become the leading indication for liver transplant (LT) in the US. Understanding its clinical burden can help to identify opportunities for prevention and treatment.ObjectiveTo project the burden of MASLD in US adults from 2020 to 2050.Design, Setting, and ParticipantsThis decision analytical modeling study used an agent-based state transition model that simulates the natural history of MASLD progression among adults 18 years of age or older. Primary data sources for model inputs were the published literature.ExposureNatural history of MASLD.Main Outcomes and MeasuresCases of MASLD, metabolic dysfunction–associated steatohepatitis (MASH), fibrosis, hepatocellular carcinoma (HCC), LT, and liver-related death.ResultsThe model simulated 2 821 624 individuals (mean age. 35.8 years; 50.9% female). The model predicted a steady increase in the prevalence of MASLD from 33.7% (86.3 million people) in 2020 to 41.4% (121.9 million people) by 2050. Cases of MASH would increase from 14.9 million (5.8% of US adults) in 2020 to 23.2 million (7.9% of US adults) by 2050. The number of cases of MASH and clinically significant fibrosis (ie, F≥F2, centrilobular and periportal fibrosis or more severe disease) were estimated to increase from 6.7 million to 11.7 million. By 2046 to 2050, MASLD would cause 22 440 new cases of HCC and 6720 new cases of LT per year compared with 11 483 new cases of HCC and 1717 new cases of LT in 2020 to 2025. Liver-related mortality was estimated to increase from 30 500 deaths (1.0% of all-cause deaths in adults) in 2020 to 95 300 deaths (2.4%) in 2050.Conclusions and RelevanceIn this decision analytical modeling study, the model forecast a substantial increase in clinical burden of MASLD over the next 3 decades in the absence of effective treatments. These results suggest that health systems should plan for large increases in the number of HCC cases and in the need for LT.
Hierarchical Composite Polyimide Aerogels with Hyperbranched Siloxane for High Electromagnetic Wave Absorption
Authors: Xu Yang , Tan Ruiyang , Jiang Xiaolin , Bo Luwei , Wang Yandong , Xu Haocheng , Chen Ping , Xi Kai 
Published: January 2025

AbstractHierarchical pore structures offer a promising strategy for developing high‐performance electromagnetic wave (EMW) absorption materials with a broad effective absorption bandwidth (EAB, reflection loss −10 dB) and reduced thickness. In this work, hyperbranched siloxane (HBPSi), featuring unparalleled 3D structure and high thermal stability, is integrated into polyimide (PI)/carbon nanotube (CNT) composite aerogels to fabricate a hierarchical pore architecture simply, resulting composite PI aerogels with macro‐mesoporous structures exhibit exceptional EMW absorption, excellent mechanical properties, and low thermal conductivities, even with a minimal CNT content of just 7.45 wt.%. This intricate hierarchical pore structure of composite PI aerogels optimizes impedance matching with air, signifying augmented multiple reflections and scattering in the 3D porous structure, thus, the composite PI aerogel with a low density (0.123 g cm−3), minimum reflection loss (RLmin) of −51.13 dB and an EAB of 4.4 GHz at a matching thickness of 3.4 mm. The innovative construction of PI/CNT composite aerogels featuring hierarchical structures provides a promising avenue for the advancement of high‐efficiency EMW absorption materials.
Nitrogen Defects and Interfacial Chemical Bonds in Fe Single‐Site Mediated C3N4 With Rod‐Like Fe2O3 Enhanced the S‐Scheme Heterojunction for Efficient Energy Conversion
Authors: Wang Xinglin , Zhang Huihui , Huang Yamei , Gao Linlin , Zhang Yu , Meng Jiayi , Liao Yifan , Zong Baoning , Dai Wei‐Lin , Li Hexing 
Published: January 2025

AbstractThe rational design of S‐scheme heterojunctions holds significant potential for efficient photocatalytic energy conversion, attributed to their enhanced carrier separation efficiency and high redox capacity. Nevertheless, achieving precise control and transfer dynamics in S‐scheme heterojunctions remains a substantial challenge. Herein, a unique architecture is devised featuring porous rod‐shaped Fe2O3 particles loaded onto Fe single‐sites modified g‐C3N4 nanosheets via single‐sites mediated heterocomponent anchorage, achieving the directed growth of Fe2O3 using Fe single‐sites in g‐C3N4 as anchoring points, thereby forming O─Fe─N interfacial chemical bonds (ICBs) and generating abundant nitrogen defects (FeO/FeCN‐Nv). Photophysical processes are further investigated using femtosecond transient absorption spectroscopy (fs‐TAS) and in situ irradiated X‐ray photoelectron spectroscopy (ISI‐XPS) with an adjustable wavelength irradiation light source. Encouragingly, the results reveal an enhanced internal electric field (IEF) is constructed at these semicoherent phase boundaries, creating an asymmetrical charge distribution. Simultaneously, Nv defects introduce an additional defect level that accelerates electron transfer through the IEF, enabling more rapid migration to surface‐active sites for both photocatalytic styrene epoxidation and hydrogen evolution. The synergistic effect of ICBs and defects coupling in regulating carrier transfer offers new insights into enhanced photocatalysis, paving the way for further advancements in energy conversion.
Electrically Detachable and Fully Recyclable Pressure Sensitive Ionoadhesive Tapes
Authors: Yue Qilin , Lv Jiahao , Huang Shuangyan , Guo Youfa , Wang Yanan , Liu Jin , Sun Shijie , Wang Ming , Wang Shanlin , Wei Yong 
Published: January 2025

AbstractDetachable pressure sensitive adhesives (PSAs) show great potential in recycling the bonded components toward a circular economy, yet the existing challenges such as strict conditions, and time‐consuming, adhesive residues after detachment significantly hinder the developments and applications. Here, a pressure sensitive ionoadhesive (PSIA) tape is first designed that has excellent interfacial toughness to various substrates (≈1.8 kJ m−2) yet can be electrically detached with high efficiency under safe voltages (≥90% within 1 min). The unique properties are achieved by introducing liquid‐free lithium salt into poly(ionic liquids) to establish multiple non‐covalent interactions (NCIs) including strong electrostatic interactions, moderate lithium bonds, weak ion‐dipole interactions, and hydrogen bonding interactions. The multiple NCIs not only strengthen the physical crosslinking networks to improve the mechanical performances but promote the dissociation of lithium salt to improve the ion transport properties. Additionally, the elaborately designed low Tg and intrinsic low modulus features endow the PSIA tape adhesion with excellent reworkability, recyclability, and re‐adhesion ability. It is believed this work offers a new strategy for designing electrically detachable and fully recyclable PSIA tapes, which facilitates the reuse and recycling of the bonded components and reduces industrial waste.
Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function
Authors: Zhu Wenjie , Chen Guanyu , Xiao Zhiqiang , Wang Minzhen , Li Zhuang , Shi Yuxun , Luo Xiaohui , Li Zuoyi , Huang Haixiang , Chen Xiaoqing , Liang Lingyi , Liang Dan 
Published: January 2025

AbstractCircadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a light‐induced circadian rhythm disruption model, we showed that disrupted circadian rhythms exacerbate autoimmune uveitis by impairing the stability and function of Treg cells. Mechanistically, we identified the core clock gene Per1, which is significantly reduced under circadian disruption, is essential for Treg cell metabolism and immunoregulatory function. This study underscores the pivotal role of circadian rhythm‐related Treg cells in autoimmune disease progression.
Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood‐Testis Barrier in Mice
Authors: Zhang Yan , Shu Mingxue , Shan Shilin , Liu Huiying , Zhang Yucheng , Song Chenyang , Xu Qiaoqiao , Fan Yun , Lu Chuncheng 
Published: January 2025

AbstractPerfluorohexane sulfonic acid (PFHxS) is extensively used in waterproof coatings and fire‐fighting foams, and several studies have found it to be a potential health hazard, but there is still unknown about its effects on spermatogenesis. Our results showed that PFHxS‐treated mice have significant reproductive toxicity, including a decrease in sperm count and motility, and the levels of sex hormones (P < 0.05). Concurrently, structural abnormalities are observed in sperm, affecting ≈60–75% of those in the PFHxS‐treated group. Additionally, it is found that the structure of the blood‐testis barrier (BTB) is damaged after PFHxS treatment, leading to higher expression levels of inflammatory cytokines in the microenvironment for spermatogenesis. Moreover, the expression of proteins associated with mitochondrial biogenesis, including PTEN‐induced kinase 1 (PINK1) and NADPH oxidase 4 (NOX4), is dysregulated in the testes after PFHxS treatment. Based on metabolome data, the differential metabolite 3‐hydroxybutanoic acid is identified in the PFHxS‐treated group, which can regulate the histone Kac levels, especially H3K4ac and H3K9ac. In summary, the results of this study suggest that in the testes of PFHxS‐treated mice, inflammatory factors disrupt the mitochondrial function and metabolic profiles and hinder the progress of gene transcription through histone Kac, ultimately causing sperm dysfunction.
ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence
Authors: Wang Yi , Wu Qiang , You Yongqing , Jiang Wenbo , Fu Peiliang , Dai Kerong , Sun Ye 
Published: January 2025

AbstractPatellar dysplasia (PD) can cause patellar dislocation and subsequent osteoarthritis (OA) development. Herein, a novel ABCA6 mutation contributing to a four‐generation family with familiar patellar dysplasia (FPD) is identified. In this study, whole exome sequencing (WES) and genetic linkage analysis across a four‐generation lineage presenting with six cases of FPD are conducted. A disease‐causing mutation in ABCA6 is identified for FPD. Further analyses reveal a consistent correlation between ABCA6 expression downregulation and PD occurrence, chondrocyte degeneration, and OA onset. Moreover, ABCA6‐KO mice demonstrate severe knee joint degeneration and accelerated OA progression. Besides, synovial mesenchymal stem cells (SMSCs) are extracted from WT, ABCA6−/+, and ABCA6−/− mice to create chondrogenic organoids in vitro, confirming ABCA6 deficiency can lead to chondrocyte degeneration via modulating cell cycle and activating cellular senescence. Moreover, transcriptome and metabolomic sequencing analysis on ABCA6‐KO chondrocytes unveils that the ABCA6 deficiency inhibits cholesterol efflux, leading to intracellular cholesterol accumulation and subsequent cellular senescence and impaired chondrogenesis.A disease‐causing mutation of ABCA6 is identified for FPD. ABCA6 is correlated with PD occurrence and subsequent OA progression. ABCA6 can serve as a potential target in chondrogenesis and OA treatment by orchestrated intracellular cholesterol efflux and delayed cellular senescence.
CircDNA2‐Educated YTHDF2 Phase Separation Promotes PM2.5‐Induced Malignant Transformation Through the Blunting of GADD45A Expression
Authors: Xu Jie , Ling Zhi , Yin Lijia , Xu Duo , Wu Shenshen , Chen Rui 
Published: January 2025

AbstractSubstantial epidemiological evidence suggests a significant correlation between particulate matter 2.5 (PM2.5) and lung cancer. However, the mechanism underlying this association needs to be further elucidated. Circular RNAs (circRNAs) have emerged as an important topic in the field of epigenetics and are involved in various cancers. This study aimed to explore the molecular basis of PM2.5‐induced lung cancer from an epigenetic perspective and identify potential biomarkers. Initially, the construction of a chronic PM2.5 exposure model confirmed that PM2.5 exposure promoted the malignant transformation of human bronchial epithelial (HBE) cells. Mechanistically, abnormally upregulated circDNA2 inhibited the tumor suppressor gene growth arrest and DNA damage 45 alpha (GADD45A) mRNA in an N6‐methyladenosine (m6A)‐dependent manner, mediated by YTH N6‐Methyladenosine RNA Binding Protein F2 (YTHDF2) after PM2.5 exposure. Further analyses revealed that circDNA2 can specifically bind to the YTHDF2 LC domain to promote YTHDF2 protein liquid–liquid phase separation (LLPS), providing sufficient evidence linking LLPS and particulate pollutant‐induced tumorigenesis. In conclusion, this study provides new insights into the role of circDNA2 in PM2.5‐induced lung cancer and confirms its clinical value as a potential prognostic biomarker for lung cancer.