bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitude, and practice of diabetes in patients with and without sight-threatening diabetic retinopathy from two secondary eye care centres in India
Authors: Pardhan Shahina , Raman Rajiv , Biswas Anupama , Jaisankar Durgasri , Ahluwalia Sanjiv , Sapkota Raju 
Published: August 2023

Abstract
Background/Aims: Good knowledge, Attitude, and Practice (KAP) of diabetes influence its control and complications. We examined the KAP of diabetes in patients with sight-threatening diabetic retinopathy (STDR) and non-sight-threatening diabetic retinopathy (NSTDR) attending two different referral hospitals in India.
Methods: 400 consecutive patients (mean age = 58.5 years ±10.3) attending retina clinics in Chennai and Darjeeling were recruited. A validated questionnaire on diabetic KAP was administered in English or the local language. Data were analysed using an established scalar-scoring method in which a score of 1 was assigned to the correct answer/healthy lifestyle and 0 to an incorrect answer/unhealthy lifestyle/practice. Clinical data included fasting blood sugar, blood pressure, retinopathy, and visual acuity. Retinopathy was graded as STDR/NSTDR from retinal images using Early Treatment of Diabetic Retinopathy Study criteria.
Results: Usable data from 383 participants (95.8%) were analysed. Of these, 83 (21.7%) had STDR, and 300 (78.3%) had NSTDR. The NSTDR group reported a significantly lower total KAP score (mean rank = 183.4) compared to the STDR group (mean rank = 233.1). A greater percentage in the NSTDR group reported to being unaware that diabetes could affect eyes, possible treatments for DR, and checked their blood sugar less regularly (<once a month).
Conclusion: Patients who had not developed STDR had poorer KAP about diabetes and diabetic-related eye diseases. This is an important issue to address as the risk of their progressing to STDR is high unless appropriate steps to improve their knowledge/awareness and lifestyle practice are introduced early.
Docking Method for Electric Vehicle Charging Terminal Using Monocular Camera
Authors: Noh Donghee , Kim Seonhyeong , Kim Seojeong , Kim Donghoon , Choi Kyoungho , Choi Juhwan , Park Keunho 
Published: August 2023

Abstract
With the growth of battery-based eco-friendly electric vehicle parts and materials technology, the diversity of smart EV-related industries is increasing. However, the lack of rapid charging stations, which hinders the growth of the eco-friendly electric vehicle market, is approaching as a realistic problem. Various companies such as Volkswagen, EVAR, KUKA, MOBI, CarLa, and TESLA are competing to develop and commercialize unmanned automated electric vehicle charging robots using robots to solve the shortage of charging stations and the inconvenience of charging electric vehicles for the physically weak such as children and the elderly. This paper conducted a study on docking and undocking the charging terminal of a battery cart to the charging terminal of an electric vehicle using hardware consisting of a monocular camera, an articulated robot, a gripper, and a server among unmanned automated electric vehicle charging systems. In order to evaluate the performance of the system, an experiment was conducted to evaluate the success rate of docking and undocking tasks, and the average success rate of 99% was derived as a result of the experiment.
Modular Self-Assembly of a Low-Symmetry Helicene Racemate into Robust yet Facilely Recyclable Noncovalent Porous Crystals
Authors: Qiu Huibin , Zhang Guoli , Zhang Jian , Tao Yu , Gan Fuwei , Lin Geyu , Liang Juncong , Shen Chengshuo , Zhang Yuebiao 
Published: August 2023

Abstract

Porous frameworks constructed via noncovalent interactions show wide potential in molecular separation, gas adsorption, etc. However, it remains a major challenge to prepare these materials from low-symmetry molecular building blocks. Herein, we report a facile strategy to fabricate noncovalent porous crystals through modular self-assembly of a low-symmetry helicene racemate. The P and M enantiomers in the racemate first stack into right- and left-handed triangular prisms, respectively, and subsequently the two types of prisms alternatively stack together into a hexagonal network with one-dimensional channels with a diameter of 14.5 Å. Remarkably, the framework reveals high stability upon heating to 275 °C, majorly due to the abundant π-interactions between the complementarily engaged helicene building blocks. Such porous framework can be readily prepared by fast rotary evaporation, and is easy to recycle and repeatedly reform. The refined porous structure and enriched π-conjugation also favor the selective adsorption of a series of small molecules.
Real Time Raspberry Pi based System for Linguistic Content Recognition from Speech
Authors: A Revahi , N Sasikaladevi 
Published: August 2023

Abstract
Recognizing linguistic information from speech has found applications in interpretation of language in which the utterance is spoken and the system could be used as a translator to convert sentence spoken in one language into another language meaningfully. Real time implementation of language identification (LID) from speech requires the speech to be fed from the Raspberry Pi board used in the transmitter section and the Raspberry Pi board in the receiver section receives it and given to the system for identifying the language of the speech. This system requires the training phase in which two dimensional spectrogram features are derived from the training set of speeches and given to the CNN layered architecture for creating templates for languages. Testing phase involves the transmission of speech from the memory card of the Raspberry Pi board in transmitter system. Raspberry Pi board in the receiver receives it and given to the system in receiver section. Two dimensional spectrogram features are derived for test speech and given to the CNN templates and based on the similarity index, test language is interpreted. This system is implemented using spectrogram, Melspectrogram and ERB spectrogram as features and CNN for modeling and classification of languages. Validation error is 1.4%, 1.8% and 3% for spectrogram, Melspectrogram and ERB spectrogram based systems respectively and decision level fusion classifier gives 0.9% as validation error. This system can be implemented in hardware by using Raspberry Pi board. This automated real time multilingual language identification system would be useful in forensic department and defense sectors to identify the persons belonging to any region or speaking in any language.
Facile Wet Chemical Synthesis of Dimeric Triangulene Derivatives through Intramolecular Radical-Radical Coupling
Authors: Shi Xueliang , Liu Peipei , Wu Meng-Xiang , Kang Hao , Zhao Xiao-Li , Yang Hai-Bo 
Published: August 2023

Abstract
Herein, two dimeric triangulene derivatives 1 and 2 were synthesized via a novel and facile wet-chemical method. The generation of 1 and 2 involved an intramolecular radical-radical coupling between two open-shell triangulene moieties. The radical-radical coupling process was found to relate closely to the spin density distributions of the two triangulene derivatives as well as the inherent steric congestion between them. Their electronic structures and conformations were thoroughly investigated by X-ray crystallography and DFT calculations. The results disclosed that 1 and 2 differed significantly in terms of electronic configurations and aromaticity, resulting in their distinct photophysical properties and molecular conformations. 1 exhibited red-shifted absorption and emission spectra compared to 2 despite the relatively smaller π-conjugation of 1. In contrast to the planar conformation of 1, 2 was highly twisted and existed in two diastereomeric forms 2-PM and 2-PP/MM which were successfully separated. The isomerization kinetics of the two diastereomers and the optical resolution and chiroptical properties of enantiomers 2-PP/MM were also systematically survived. We believe that our studies including the new elegant wet chemical synthesis methodology and interesting radical-radical coupling process will open up a new way to understand the chemical versatility of triangulenes and related π-conjugated systems.
Preparation of stable colloidal dispersion of surface modified Fe 3 O 4 nanoparticles for magnetic heating applications
Authors: Dizajyekan Behnam Sabzi , Jafari Arezou , Vafaie-Sefti Mohsen , saber Reza , Fakhroueian Zahra 
Published: August 2023

Abstract
The effect of surface modification on enhancing the magnetic heating behavior of magnetic nano fluids were investigated, for this purpose Fe3O4 nanoparticles were synthesized using co-precipitation method and surface modification was done using citric acid, ascorbic acid, tetraethyl orthosilicate (TEOS), polyvinyl alcohol (PVA) and polyethylene glycol (PEG). Experimental heating tests using AC magnetic field were done in the frequency of 100 kHz and different magnetic field (H) intensities. Theoretically the Specific Absorption Rate (SAR) in magnetic nano fluids is independent of nanoparticles concentration but the experimental results showed different behavior. The Theoretical SAR value @ H=12kA.m-1 for Nano fluids containing bare Fe3O4 nanoparticles was 11.5 W/g but in experimental tests the obtained value was 9.72 W/g for nano fluid containing 20000 ppm of dispersed nanoparticles. The experimental SAR calculation was repeated for sample containing 10000 ppm of nanoparticles and the results showed increase in experimental SAR that is an evidence of nanoparticles agglomeration in higher concentrations. The surface modification has improved the dispersion ability of the nanoparticles. The Ratio of SAR, experimental, 20000ppm to SAR, experimental, 10000ppm was 0.85 for bare Fe3O4 nanoparticles dispersion but in case of surface modified nanoparticles this ratio has increased up to 0.98 that shows lower agglomeration of nanoparticles as a result of surface modification, although on the other hand the surface modification agents were magnetically passive and so it is expected that in constant concentration the SAR for bare Fe3O4 nanoparticles to be higher than this variable for surface modified nanoparticles. At lower concentrations the dispersions containing bare Fe3O4 nanoparticles showed higher SAR values but at higher concentrations the surface modified Fe3O4 nanoparticles showed better results although the active agent amount was lower at them. Finally it should be noted that the nanoparticles that were surface modified using polymeric agents showed the highest decrease in experimental SAR amounts comparing theoretical results that was because of the large molecules of polymers comparing other implemented surface modification agents.
Outcomes of a nurse practitioner-led, intravenous dexmedetomidine-based pediatric sedation program for Magnetic Resonance Imaging in a general hospital. A prospective observational study.
Authors: schuiten linda , Valerio Paolo , Leroy Piet L 
Published: August 2023

Abstract
Purpose
Prospective observational study on the effectiveness and safety of a nurse practitioner-led pediatric sedation program for Magnetic Resonance Imaging (MRI) with intravenous dexmedetomidine in a Dutch general hospital.
Methods
115 children, aged 6 months to 11 years, scheduled for MRI, underwent 119 sedations with an intravenous (IV)-loading dose dexmedetomidine (3μgr/kg) followed by continuous infusion (2 μgr/kg/h). Great emphasis was put on non-pharmacological strategies to create a quiet environment and to reduce patients’ anxiety.
The observed outcomes were sedation time, recovery time, Ramsay Sedation Scores (RSS), sedation failure and adverse events.
Results
Median sedation time was 52 minutes (range 27-148 minutes). Median recovery time was 82 minutes (range 5-177 minutes). Deepest individual RSS ranged from 4 to 6 (11,8% deepest RSS 4, 69,3% deepest RSS 5, 18,8% deepest RSS 6). All sedations (100%) were successful. One patient (0,8%), experienced a brief episode of oxygen desaturation as low as 90%, rapidly resolving after low-flow oxygen therapy. Two patients (1,6%), experienced an episode of mild hypotension respectively during and immediately after dexmedetomidine administration. Both quickly normalized after a fluid bolus. One patient (0,8%) experienced post-sedation nausea.
Conclusions
Sedation with intravenous dexmedetomidine for MRI can be safely and effectively entrusted to a competent nurse practitioner-led pediatric sedation team. To achieve high success rates, mastering the typical sedative characteristics of dexmedetomidine is essential, including the application of optimal logistics, consistent use of non-pharmacological comfort strategies and an effective, goal-directed collaboration between all involved.
Successful rituximab therapy for skin sclerosis and myositis in a patient with systemic sclerosis, myositis and Sjögren’s syndrome associated with autoimmune polyglandular syndrome
Authors: Saeki Takako , Nishiyama Hiroki , Sakai Shunsuke , Kimura Haruna , Usuda Hiroyuki , Furukawa Kazuo 
Published: August 2023

Abstract
Background: Autoimmune polyendocrine syndromes (APSs) are relatively rare clinical conditions characterized by functional impairment of multiple endocrine glands due to loss of immune tolerance. These syndromes are broadly categorized as rare monogenic forms, such as APS-1, and a more common polygenic variety, APS-2. In APS-2, many autoimmune conditions can develop, including autoimmune rheumatic diseases. However, systemic sclerosis and myositis can occur as quite rarecomplications, for which no treatment strategy has yet been established.
Case presentation: A 25-year-old man who had been diagnosed as having type 1 diabetes developed finger stiffness. Although the subjective symptoms were relatively mild, extensive examinations including various autoantibodies, hormones and biopsy of the skin and minor salivary glands revealed that he had APS-2 (type 1 diabetes and autoimmune thyroid disease) accompanied by systemic sclerosis, myositis and Sjögren’s syndrome. Rituximab therapy was initiated for the progressive skin sclerosis, and this resulted in significant of both the sclerosis and the myositis.
Conclusion: Various autoimmune rheumatic diseases can develop in APS-2. Early diagnosis and immunomodulatory therapy may arrest the autoimmune process before irreversible organ damage has occurred, and rituximab appears to be a promising therapy for autoimmune rheumatic diseases associated with APS-2.
Machine Learning and Deep Learning based Students’ Grades Prediction
Authors: Adil Korchi , Messaoudi Fayçal , Ahmed Abatal , Youness Manzali 
Published: August 2023

Abstract
Predicting student performance in a curriculum or program offers the prospect of improving academic outcomes. By using effective performance prediction methods, instructional leaders can allocate adequate resources and instruction more accurately. This paper aims to identify the features of machine learning algorithms that can be used to make predictions about student grades. For this purpose, we use a data set that contains personal information about students and their grades. We have implemented different machine learning algorithms of regression namely: Decision Tree, Random Forest, Linear Regression, k-Nearest Neighbor, XGBoost, and Deep Neural Network. Then, we compared these models based on their determination coefficient, Mean Average Error, Mean Squared Error, and Root Mean Squared Error. The experimental results of this study showed that the deep neural network outperformed the other algorithms with a determination coefficient of 99.97% and low errors.
Endometrial injection of embryo culture supernatant may adversely affect assisted reproductive technology outcomes in frozen-thawed embryo transfer cycles: A retrospective case-control study
Authors: Ito Ayumu , Katagiri Yukiko , Nakaoka Kentaro , Unagami Mami , Ichizawa Koichiro , Amano Kenji , Tokuda Yukiko , Oigawa Satoko , Yoneyama Masato , Tsuchiya Takahiro , Sekiguchi Mami , Furui Mayuko , Umemura Nahomi , Hayashi Yuko , Tamaki Yuko , Nagao Koichi , Nakata Masahiko 
Published: August 2023

Abstract
Purpose
This study aimed to determine the effects of endometrial injection of embryo culture supernatants on assisted reproductive technology (ART) outcomes in frozen-thawed embryo transfer (FET) cycles.
Methods
We included hormone replacement therapy cycles, with the transfer of embryos reaching the blastocyst on day 5 after fertilization. To mitigate any potential bias, we excluded cycles that possibly affected implantation. We included 118 cycles in the stimulation of endometrial embryo transfer (SEET) group (participants received an endometrial injection of the embryo culture supernatant) and 878 cycles in the blastocyst transfer (BT) group (participants did not receive the embryo culture supernatant).
Results
Maternal age was significantly higher in the SEET group than in the BT group (p < 0.05). The implantation rate (p < 0.05), ongoing pregnancy rate (p < 0.05), and live birth rate (p < 0.05) were significantly lower in the SEET group than in the BT group. There was no significant difference in the clinical pregnancy and miscarriage rates between the groups. The age-adjusted odds ratios (ORs) for implantation and miscarriage were 0.70 and 1.52, respectively, in the SEET group. The age-adjusted OR for implantation was 1.0 and 0.29 for good-quality blastocysts (GQBs) and non-GQBs, respectively, in the SEET group compared to the BT group. The age-adjusted OR for miscarriage was 0.81 and 2.2 for participants aged < 37 and ≥ 37 years, respectively, in the SEET group compared to the BT group.
Conclusions
Endometrial injection of the embryo culture supernatant may adversely affect ART outcomes in FET cycles, especially in non-GQB embryo transfers and mothers aged ≥ 37 years.
Profile of Secondary Glaucoma in Menelik II Specialized Hospital, Addis Ababa, Ethiopia
Authors: Gebrekidan Gebreabzgi Teklay , Alemu Abiye Mulugeta 
Published: August 2023

Abstract
Purpose
To determine the current clinical profile, proportion, and causes of various types of secondary glaucoma in newly diagnosed glaucoma patients at Menelik II Specialized Hospital, Ethiopia.
Methods
This is a hospital-based cross-sectional descriptive study conducted at a glaucoma clinic between May 1 - July 31, 2022. All newly diagnosed secondary glaucoma patients aged 18 years and above were included. A structured format comprising socio-demographic data, history, best-corrected visual acuity, intraocular pressure, slit-lamp, gonioscopy, fundus examination findings, and finally, the diagnosis was used. Data management and analysis were done using SPSS version 26.
Results
Four-hundred forty-nine new glaucoma patients visited the clinic during the study period. One hundred seventy-three (38.53%) patients were diagnosed to have secondary glaucoma. The leading causes of secondary glaucoma were found to be Pseudoexfoliative glaucoma (75.5%), followed by neovascular glaucoma (7%), uveitic glaucoma (6.7%), lens-induced glaucoma (5%), and miscellaneous causes (5.7%). Secondary glaucoma was a significant cause of visual morbidity, with 57.04% of eyes presenting with best corrected visual acuity < 6/60, IOP > 30 mm Hg in 45.3% of eyes, and 61.74% with a cup-to-disc ratio of ≥ 0.7.
Conclusion
Secondary glaucoma is a significant cause of visual morbidity. Timely diagnosis and early and appropriate management are essential to prevent irreversible visual loss.
PRDX4 regulates AMs cell activity through the AKT/NF-κB pathway to inhibit the progress of pulmonary fibrosis
Authors: Zhou Jia wei , Liu Ziqin , Liu Yafeng , Guo Jianqiang , Yang Xuelian , Li Yunyun , Bai Ying , Xing Yingru , Wu Jing , Hu Dong 
Published: August 2023

Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that leads to severe lung fibrosis, and PRDX4 expressed highly in AMs may be closely related to the process of fibrosis progression. This study investigates the function and molecular mechanisms of the potential therapeutic target PRDX4 in idiopathic pulmonary fibrosis (IPF).
Methods
This study utilized single-cell RNA sequencing (scRNA-seq) of lung tissue, transcriptome sequencing (RNA-Seq) of bronchoalveolar lavage fluid (BALF), and clinical data retrieval to investigate key cells influencing inflammation and fibrosis in patients with idiopathic pulmonary fibrosis (IPF), and to analyze the expression and prognostic value of PRDXs. AAV-mediated knockdown of PRDX4 protein expression was performed specifically in alveolar macrophages (AMs) of IPF mice, and lung function as well as changes in inflammatory and fibrotic gene expression were evaluated. In vitro cell experiments and tissue immunofluorescence were conducted to investigate the regulatory mechanisms of PRDX4 both in vivo and in vitro.
Results
Alveolar macrophages (AMs) and type II lung epithelial cells (AT2) are the major contributing cells for inflammation and fibrosis genes in lung tissue of IPF patients. High expression of PRDX4 in AMs is significantly negatively correlated with patient prognosis (p < 0.05). Functionally, knockdown of PRDX4 expression in AMs effectively improves lung function (EF50, VT, and MV) in IPF mice, while inhibiting the expression of genes related to lung inflammation and fibrosis. Mechanistically, PRDX4 can regulate the secretion of inflammation-related factors in AMs through the AKT/NF-κB pathway, thereby inhibiting the progression of inflammation and fibrosis in IPF mice.
Conclusions
Inhibiting the expression of PRDX4 in alveolar macrophages (AMs) can modulate the activity of these cells, thereby suppressing the progression of IPF disease.
The potential mechanism and chemical compounds contributed to Psoraleae Fructus-induced hepatotoxicity from the aspect of mitochondrial dysfunction
Authors: Shang Huiying , Liu Xian , Pan Jinchao , Tang Xianglin , Cheng Hongbo , Ma Zengchun , Xiao Chengrong , Gao Yue 
Published: August 2023

Abstract
Background
Psoraleae Fructus (PF) is a widely-used traditional Chinese medicine in Asia for osteoporosis and vitiligo. The cases of PF-induced hepatotoxicity were frequently reported, which restricted its clinical application. However, the potential hepatotoxic components and the underlying mechanisms remain to be fully elucidated.
Methods
Kunming mice were intragastrically administrated with salt-processed Psoraleae Fructus (SPF) water extracts for 4 weeks. The pathohistological changes and biochemical assays were performed to evaluate the level of hepatic injuries. Transcriptomic analysis, western blots and qPCR were applied to investigate the potential mechanism. Further high content screening was conducted to identify the potential mitotoxic chemicals in PF.
Results
SPF promoted hepatic steatosis by inhibiting the expressions of ACOX1, ACADM, CPT1 and CYP7A1. SPF led to mitochondrial structure damage and the decrease of mtDNA copy number. Transcriptomic analysis and western blots validated the impairment of mitochondrial oxidative phosphorylation (OXPHOS) contributed to SPF-induced liver injuries. Considering the high relevance of mitochondrial function with SPF-induced hepatotoxicity, high content screening was conducted to identify the mitotoxic chemicals in SPF. At the same concentration, bavachin, isobavachalcone, psoralidin and bakuchiol showed the most potent mitochondrial toxicity by decreasing mitochondrial membrane potential, increasing mitochondrial superoxide level and the opening of mitochondrial permeability transition pore.
Conclusions
Our study unveiled SPF promoted hepatic injury by inducing mitochondrial dysfunction and the potential mitotoxic chemical constituents in SPF.