bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Symptoms and Mode of Transportation to Emergency Department in Patients With Acute Coronary Syndrome
Authors: Davis Leslie L. , McCoy Thomas P. , Riegel Barbara , McKinley Sharon , Doering Lynn V. , Moser Debra K. 
Published: January 2023

Background
Patients with acute coronary syndrome (ACS) with symptoms matching their expectations of a heart attack are more likely to use emergency medical services (EMS) than not.

Objective
To determine whether presenting symptom clusters are associated with EMS use in ACS patients and if EMS use or symptom clusters are associated with prehospital delay.

Methods
This secondary analysis used data from the PROMOTION trial, a randomized clinical trial that enrolled 3522 subjects with a history of or at risk for ACS from 5 sites in the United States, Australia, and New Zealand. Subjects were randomized to usual care or an educational intervention to reduce prehospital delay. During the 2-year follow-up, subjects admitted for ACS were asked about symptoms, time of symptom onset, and mode of transportation to the hospital. Symptoms were grouped into classic ACS, pain symptoms, and stress symptoms clusters.

Results
Of 3522 subjects enrolled, 331 sought care for ACS during follow-up; 278 had transportation mode documented; 121 (44%) arrived via EMS. Classic ACS plus pain symptoms (adjusted odds ratio [AOR], 2.66; P = .011), classic ACS plus stress symptoms (AOR, 2.61; P = .007), and classic ACS plus both pain and stress symptoms (AOR, 3.90; P = .012) were associated with higher odds of EMS use versus classic ACS symptoms alone. Emergency medical services use resulted in a 68.5-minute shorter median delay (P = .002) versus non-EMS use. Symptom clusters were not predictive of delay time in the adjusted model (P = .952).

Discussion
Although chest symptoms were the most prevalent symptoms for most (85%), the combination of classic ACS symptoms with other symptom clusters was associated with higher EMS use. Further research is needed to determine whether a combination of symptom clusters helps patients correctly interpret ACS symptoms to better understand how symptom clusters influence EMS use.
Thulium fiber laser in endourology: current clinical evidence
Authors: Enikeev Dmitry , Herrmann Thomas R.W. , Taratkin Mark , Azilgareeva Camilla , Borodina Anastasia , Traxer Olivier 
Published: January 2023

Purpose of review
To review and summarize preclinical and clinical data on thulium fiber laser's (TFL) effectiveness (ablation rate, stone-free rate etc.) and safety in terms of laser injuries and thermal damage. This enables us to assess how the in-vitro evidence translates into the clinical real-life scenario.

Recent findings
In this analysis, a total of 21 preclinical trials have been included. Most of the trials use conventional Holmium:YAG laser as a comparator, with only a few assessing lasers with pulse modulation. Most of the trials focus on the superior ablation rate and superior dusting features of TFL, as well as comparison of retropulsion (both in conventional Ho:YAG and in a pulse modulation), with a few studies assessing safety aspects. A total of 13 trials assessed TFL, clinically, in percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS). The clinical data obtained suggest that lithotripsy by TFL is safe, facilitates effective stone fragmentation, and results in a reduction of retropulsion. Unfortunately, most of the clinical trials lack a direct comparator, and so no clear-cut comparisons are possible.

Summary
During in-vitro studies, TFL demonstrated to be a new energy source with a great potential for improved ablation, lower retropulsion and improved dusting. These claims are supported in contemporary clinical studies, reporting superior ablation and negligible retropulsion in both PCNL and RIRS. However, it should be noted that the data regarding clinical results compared with conventional Ho:YAG is still limited.
The Use of Ketamine Sedation for the Treatment of Nail Bed Repairs in the Pediatric Emergency Department
Authors: Stewart Charles , Bradley Alice , Faulkner Jordan , Jatan Anita 
Published: January 2023

Aim
This study aimed to determine if sedation with ketamine is safe and effective for the treatment of nail bed injuries in the pediatric emergency department (PED).

Method
A retrospective cohort study was carried out during a 9-month period in children aged between 18 months and 15 years, presenting to PED requiring nail bed repair. We documented complications of sedation, clinical outcome of the repair both immediate and at follow-up, and parental satisfaction at 4 months. A cost analysis was also undertaken.

Results
Ten repairs were performed. There were no serious adverse events. The average satisfaction score was 9.4/10. All patients were discharged from follow-up by 3 months. There was a cost saving of approximately £1500 per case.

Conclusions
We have demonstrated nail bed injury repair facilitated by sedation with ketamine to be safe, effective, and cost efficient in the PED. This management strategy, brought to the fore during the COVID-19 pandemic, should be adopted widely in PEDs.
Peritoneal Metastases From Prostate Carcinoma Treated With 177Lu-PSMA-I&T
Authors: van Golen Larissa W. , Seijkens Tom T.P. , de Feijter Jeantine M. , Vogel Wouter 
Published: January 2023

Abstract
A 71-year-old man was referred for 177Lu-PSMA therapy. He had metastatic castration-resistant prostate cancer, progressive on several treatment lines, with current PSA 260 μg/L and deteriorating condition. CT showed ascites with omental and peritoneal metastases, all positive on PSMA PET/CT. He was treated with 4 cycles of 7.4 GBq (0.2 Ci) 177Lu-PSMA-I&T. Posttherapy scans showed good targeting of all metastases. After 4 cycles, PSA had dropped to 44 μ/L. Four months after the fourth cycle, the patients’ general condition had significantly improved, and PSA had decreased to 7.0 μg/L.
FDG PET/CT in a Case of Primary Angiosarcoma of the Kidney
Authors: Yang Jian , Dong Aisheng , Nian Shensheng , Peng Yonghan , Zuo Changjing 
Published: January 2023

Abstract
Primary angiosarcoma of the kidney is a rare aggressive malignancy. We describe MRI and FDG PET/CT findings in a case of primary renal angiosarcoma with hepatic, pulmonary, and bony metastases. The large primary tumor showed extensive necrosis and increased FDG uptake in the nonnecrotic components. Multiple metastatic lesions in the liver, lung, and bones were detected by FDG PET/CT. Most of the hepatic metastases seen on MRI were missed on FDG PET/CT due to low FDG avidity.
No compliment for complement: Kidney biopsies of patients with malignant nephrosclerosis show no complement activation
Authors: Alba Schmidt Elisa M. , Tomas Nicola , Huber Tobias , Wiech Thorsten , Schmidt Tilman , Wenzel Ulrich Otto 
Published: January 2023

ABSTRACTThe complement system represents an ancient part of innate immunity and is comprised of multiple serum proteins. In several pathological conditions, including atypical hemolytic syndrome (aHUS), complement activation is contributing to disease progression. Therefore, pharmacological targeting of complement is a viable therapeutic strategy in this population.Recent data suggest complement activation in patients suffering from malignant hypertension and stenosing arteriosclerosis also called malignant nephrosclerosis (MNS). Since MNS and aHUS also share histopathological similarities therapeutic complement inhibition became a discussion in MNS.To eliminate the pitfall of confusing complement trapping with activation in the kidney we used the proximity ligation assay to detect, visualize and quantify assembled complement convertases of the different pathways in renal tissue diagnosed with MNS or aHUS. We compared them to a control group of patients presenting with thin basement membrane syndrome (TBMD). Activation of the alternative and the classical pathways were examined by glomerular and vascular quantification of C3b/Bb and C4b/C2b, respectively.We found an overactivation of the alternative pathway only in patients suffering from aHUS, while complement activation was not altered in MNS when compared with TBMD. Thus our results cannot contribute to the hypothesis that complement inhibition may be an efficient therapeutic strategy for patients presenting end-organ damage due to stenosing arteriosclerosis. The use of complement inhibition in these patients cannot be recommended.
Development of a new bioinspired peptide with fibroblast relaxation proprieties for cosmetics applications
Authors: Mortari Márcia Renata , Silva Ramalho João Daivison , Camargo Nichollas Serafim , Ferreira Guilherme Alves , Andrade Sheila Siqueira , Figueiró Longo João Paulo 
Published: January 2023

AbstractThe cosmetic field is driven by the development of new inputs and raw materials that are used to the development innovative products for consumers. Among the different sub-areas in cosmetology, skin care is the biggest area, with almost fifty percent of the market, and probably the most innovative of them. Thus, there is a complex value chain organized to develop and produce innovative inputs to supply the demands of the market. Within this context, different basic scientific areas, such as biochemistry and biotechnology, have been a source of inspiration for new active ingredients. In the present article, we will present the pre-clinical and clinical trials involved in the development of a new innovative biomimetic peptide derived from natural wasp venoms content. This new peptide sequence, here named WASP-PEP was designed based on natural peptide templates with some strategic amino acid modifications to increase the molecule’s effectiveness. As the main results, we observed that the WASP-PEP is a biocompatible and dermatology tolerate compound, and the peptide can promote some relaxation effects in dermal fibroblasts. This relaxation effect is compatible with a kind of regulated and cumulative botox-like effect. Notablyr, this relaxation effect was also observed in the clinical trial, when volunteer subjects reported that their facial skin was flatter after the use of the WASP-PEP product for one month.Graphical Abstract
Multi-omics Comparison among Populations of Three Plant Sources of Amomi Fructus
Authors: Chen Xinlian , Sun Shichao , Han Xiaoxu , Li Cheng , Nie Bao , Hou Zhuangwei , Ji Jiaojiao , Han Xiaoyu , Zhang Lixia , Yue Jianjun , Yang Depo , Wang Li 
Published: January 2023

ABSTRACTAmomi Fructus (Sharen, AF) is a traditional Chinese medicine (TCM) from three source species (or subspecies) includingWurfbainia villosavar.villosa(WVV),W. villosavar.xanthioides(WVX) orW. longiligularis(WL). Among them, WVV has been transplanted from its top-geoherb region Guangdong to its current main production area Yunnan for more than 50 years in China. However, the genetic and transcriptomic differentiation among multiple AF source (sub)species and between the origin and transplanted populations of WVV is unknown. In our study, the observed overall higher expression of terpenoid biosynthesis genes in WVV than that of WVX supplied possible evidence for the better pharmacological effect of WVV. We also screened ten candidateborneol dehydrogenase(BDH) genes that potentially catalyzed borneol into camphor in WVV. TheBDHgenes may experience independent evolution after acquiring the ancestral copies and the followed tandem duplications might account for the abundant camphor content in WVV. Furthermore, four populations of WVV, WVX and WL are genetically differentiated and the gene flow from WVX to WVV in Yunnan contributed to the increased genetic diversity in the introduced population (WVV-JH) compared to its top-geoherb region (WVV-YC), which showed the lowest genetic diversity and might undergo genetic degradation. In addition,TPSandBDHgenes were selected among populations of multiple AF source (sub)species and between the top-geoherb and non-top-geoherb regions, which might explain the metabolite difference of these populations. Our findings provide important guidance for the conservation, genetic improvement, industrial development of the three source (sub)species, and identifying top-geoherbalism with molecular markers and proper clinical application of AF.
Co-evolution integrated deep learning framework for variants generation and fitness prediction
Authors: Tan Xiaoqin 
Published: January 2023

AbstractPandemic caused by viral protein is characterized by waves of transmission triggered by new variants replacing old ones, resulting in immune escape and threatening public health. Therefore, there is an obvious need to accurately identify the vital mutation sites and understand the complex patterns of mutation effect of viral protein. However, existing work do not explicitly modelling vital positions functioning for virus fitness, leading to large search space with money- and time-consuming search cost. Here, we propose EVPMM (evolutionary integrated viral protein mutation machine), a co-evolution profiles integrated deep learning framework for dominant variants forecasting, vital mutation sites prediction and fitness landscape depicting. It consists of a position detector to directly detect the functional positions as well as a mutant predictor to depict fitness landscape. Moreover, pairwise dependencies between residues obtained by a Markov Random Field are also incorporated to promote reasonable variant generation. We show that EVPMM significantly outperforms existing machine learning algorithms on mutation position detection, residue prediction and fitness prediction accuracies. Remarkably, there is a highly agreement between positions identified by our method with current variants of concern and provides some new mutation pattern hypothesis. The method can prioritize mutations as they emerge for public health concern.
Learning in metaverse: the immersive atelier model of the architecture studio
Authors: Sopher Hadas , Lescop Laurent 
Published: January 2023

PurposeThis paper aims to describe the immersive atelier model (IAM), a pedagogical model for remote inter-university studios that promotes quality education. The IAM uses multi-user virtual environments (MUVEs) in two atelier types: A predefined MUVE and a student-shaped one. The study questions how the IAM, using MUVEs, meets the needs of remote inter-university studios. The research explores how MUVE types are used and experienced by students.Design/methodology/approachForty-six students that participated in a remote studio course involving three universities were monitored through observations and a post-course questionnaire, responded to by twenty-five students.FindingsFindings provide insights into the learners’ experience and a rich description of the teaching and learning acts that emerged while using the MUVEs types. Student-shaped MUVEs were found particularly supportive of acts associated with indirect learning and conceptualization. The study identifies subtypes of student-shaped MUVEs that support these desired educational acts.Research limitations/implicationsFindings provide encouraging insights for expanding the traditional atelier beyond its physical constraints and supporting sustainable quality education in remote inter-university studios.Practical implicationsThe IAM can assist tutors in designing future virtual design studios to achieve diverse knowledge and learning progress.Social implicationsThis paper fulfills an identified need to update the atelier pedagogical model to support sustainable quality education in remote inter-university studios. Based on the affordances of MUVEs, the IAM expands the traditional atelier with types of virtual ateliers to support the learners’ sense of belongingness and engagement.Originality/valueInnovatively, the IAM simultaneously uses MUVEs as educational and design spaces that enhance learning.
Collaboration and interaction with smart mechanisms in flipped classrooms
Authors: Hwang Wu-Yuin , Nurtantyana Rio , Hariyanti Uun 
Published: January 2023

PurposeThis study aimed to investigate learning behaviors deeply in flipped classrooms. In addition, it is worth considering how to help learners through recognition technology with natural language processing (NLP) when learners have question and answer (Q&A). In addition, the Internet of Things (IoT) can be utilized to make the physical learning environment more comfortable and smarter.Design/methodology/approachThe authors developed smart learning environment (SLE) with smart mechanisms supported by recognition technology, NLP and IoT to help learners and employed scaffolding to facilitate their group discussions. This study is an explanatory research to investigate graduate learners' learning behavior when they are collaborating with group members and interacting with the environment in flipped classroom using the proposed SLE.FindingsThe results revealed that learners who collaborated more while coediting had significant learning achievement, and NLP sufficiently addressed their questions. Physical conditions of the SLE were comfortable for learners. They perceived that SLE could facilitate group discussions with scaffolding.Practical implicationsThis study suggests to utilize flipped classrooms with technologies, e.g. Google Slides integration, to help learners to do more collaboration and use smart mechanisms, e.g. Q&A with NLP, to make learners more interacting during the discussion process.Originality/valueThe proposed SLE can record and analyze smartly their collaboration meaningfully with group members and interact with the environment. Accordingly, researchers found that collaboration in flipped classrooms can help their learning achievement, and it is worth being widely promoted.
You have to pay to play: housing costs and barriers to participation for student interns
Authors: Alteri Ashley 
Published: January 2023

PurposeMany low-income students are unable to participate in internship programs because they lack financial resources to pay for the cost of housing and relocating to the internship site. This paper examines the types of benefits or supports related to housing and relocation that employers are providing to paid interns.Design/methodology/approachThis paper uses content analysis to examine the types of supports included in job advertisements posted on Handshake, the largest early career networking platform in the US.FindingsDuring the period studied, less than 11% of internships advertised indicated that the employer was willing to provide housing or relocation support, only 107 employers across the US. Only 53 employers were willing to provide free company-sponsored housing. Internships offering support are clustered in the fields of business, engineering and research, providing almost no internships for students in other fields.Practical implicationsGiven the high cost of housing, if a student does not have access to considerable financial resources, they are unlikely to participate in an internship or will be limited to a position in their commutable area. To level the playing field among all students, employers need to offer free or subsidized company-sponsored housing to student interns. While some employers do offer support, the number of students needing support far exceeds the number of internships available.Originality/valueWhile there is information on what students identify as barriers, there is no accurate picture of employer supports available to mitigate these barriers. This exploratory analysis is the first to examine the benefits and supports employers are providing to paid interns.
Effects of geometrical parameters on thermohydrodynamic performance of a bearing operating with nanoparticle additive oil
Authors: Dal Abdurrahim , Sahin Mahir , Kilic Mustafa 
Published: January 2023

Purpose
Bearing performance characteristics, such as stiffness and load capacity, are related to the viscosity of the fluid circulating through the gap. Nanoparticle additives in lubricant are one way to enhance of the viscosity. This study aims to investigate the effect of nanoparticle additives on the thermohydrodynamic performance of journal bearing with different bearing parameters.

Design/methodology/approach
The temperature distribution is modeled using a three-dimensional energy equation. The velocity components are calculated on the pressure distribution governed by Dowson’s equation. Moreover, the heat transfer between the journal and lubricant is modeled with Fourier heat conduction equation. On the other hand, the viscosity equation is derived for Al2O3 nanoparticles as a function of the volume ratio and the temperature. An algorithm based on the finite difference method is developed, and a serial simulation is performed for different parameters and different volume ratio of nanoparticle.

Findings
With the increase in the nanoparticle volume ratio, the maximum temperature decreases for the lower clearance values, but the addition of the nanoparticle influence on the maximum temperature reverses when the clearance grows up. The nanoparticle additives increase further the maximum temperature for higher values of L/D ratios. Moreover, the effects of the nanoparticle additives on the pressure are stronger at high eccentricity ratios for all bearing parameters.

Originality/value
This paper provides valuable design parameters for journal bearing with lubricant containing the nanoparticle additives.
Unveiling the effects of big data analytics capability on innovation capability through absorptive capacity: why more and better insights matter
Authors: Lozada Nelson , Arias-Pérez José , Edwin Alexander Henao-García 
Published: January 2023

PurposeDespite the increase in studies focused on analyzing the potential of big data analytics capability (BDAC) as a driver of product and process innovation, it is still necessary to understand how the use of insights generated by BDAC in innovation may be maximized through articulation with individuals' intellect and other processes involving the assimilation and transformation of knowledge. This study thus aims to analyze the impact of BDAC's deployment on innovation capability (IC – process and product innovation capabilities), taking absorptive capacity (AC) as mediating variable in this relationship.Design/methodology/approachStructural equations were used to test the research model with survey data from 112 firms located in an emerging country that is one of the digital transformation leaders in the region.FindingsThe results show that 37% of process IC variance is explained by the indirect relationship via the variable mediator (AC), while in the case of product IC this percentage is 34%.Originality/valueThese results allow us to ascertain the extent to which individuals continue to be relevant to generating product and process innovation in the digital age at a time when the literature anticipates a total loss of prominence due to the arrival of new digital technologies. However, in the case of the relationship between BDAC and ICs, the existence of a partial mediation of AC indicates that individuals continue to play a role that, albeit not being the most prominent, remains relevant in ensuring that a company maximizes the assimilation and transformation of the insights generated by BDAC in new products and processes.