bluuebunny/crossref_metadata_2025_split huggingface dataset:
RINGO: A RINEX pre-processing software for multi-GNSS data
Authors: Kawamoto Satoshi , Takamatsu Naofumi , Abe Satoshi 
Published: April 2023

AbstractWe have developed a new multi-GNSS data pre-processing software “RINGO” that provides various features including editing, quality checking, clock jump correction, higher order ionosphere correction, conversion of BINEX and RTCM files, and an interactive viewer for RINEX files. The recent increase in number of GNSS satellites has made GNSS data more complex; however, the software available to pre-process them is very limited. RINGO is a command line tool capable of handling multi-GNSS data, including GPS, QZSS, GLONASS, Galileo, and other systems in RINEX 2.xx, 3.0x, and 4.00 formats, which allows users to easily manage the multi-GNSS data observed at continuously operating reference stations. We present algorithms and applications for each RINGO feature. The results of the quality check feature were compared with results estimated by other existing software packages. Our results agreed well with those of the TEQC software. With RINGO, users can easily pre-process multi-GNSS data without combining multiple tools, and the software will contribute to the popularization of the latest RINEX format.
Graphical Abstract
Accessing the energy-limited and sparsely populated deep biosphere: achievements and ongoing challenges of available technologies
Authors: Morono Yuki 
Published: April 2023

AbstractMicrobes in marine sediments detected and counted by direct observation of membrane-filtered sediment samples stained with acridine orange. This technique can still be applied to high-biomass (> 105 cells/cm3) sedimentary habitats, such as organic-rich sediments collected in shallow areas near the seafloor. However, to further explore the nutrients and energy turnover under extremely low energy flux conditions, or in habitats that are close to the lower limit of the biosphere, technological breakthroughs have been required to increase the detection sensitivity for microbial life at densities of a few cells/cm3 of sediment. These technological developments contributed to increasing fundamental information on microbial life at the fringes of the subseafloor biosphere and led to the discovery of revivable microbes in sediments aged up to 101.5 million years old. More recently, chemical detection methods have revealed the existence of spores in the deep biosphere that are impermeable to conventional DNA stains. Previous applications of molecular biology-based approaches have been limited to relatively higher biomass samples, potentially because the cells surviving in these very low energy flux environments have less integrated genomes. Here, I review the contribution and importance of the technological developments that have been made in the study of microbes from the subseafloor biosphere, recent developments of alternative methods to microscopically detect microbial spores and their application to deep subseafloor sediments, and the challenges associated with applying molecular biological approaches to study low-biomass samples.
Dark-zone alterations expand throughout Paleolithic Lascaux Cave despite spatial heterogeneity of the cave microbiome
Authors: Bontemps Zélia , Prigent-Combaret Claire , Guillmot Alice , Hugoni Mylène , Moënne-Loccoz Yvan 
Published: April 2023

AbstractBackgroundCave anthropization related to rock art tourism can lead to cave microbiota imbalance and microbial alterations threatening Paleolithic artwork, but the underpinning microbial changes are poorly understood. Caves can be microbiologically heterogeneous and certain rock wall alterations may develop in different rooms despite probable spatial heterogeneity of the cave microbiome, suggesting that a same surface alteration might involve a subset of cosmopolitan taxa widespread in each cave room. We tested this hypothesis in Lascaux, by comparing recent alterations (dark zones) and nearby unmarked surfaces in nine locations within the cave.ResultsIllumina MiSeq metabarcoding of unmarked surfaces confirmed microbiome heterogeneity of the cave. Against this background, the microbial communities of unmarked and altered surfaces differed at each location. The use of a decision matrix showed that microbiota changes in relation to dark zone formation could differ according to location, but dark zones from different locations displayed microbial similarities. Thus, dark zones harbor bacterial and fungal taxa that are cosmopolitan at the scale of Lascaux, as well as dark zone-specific taxa present (i) at all locations in the cave (i.e. the six bacterial generaMicrobacterium, Actinophytocola, Lactobacillus,Bosea, NeochlamydiaandTsukamurella) or (ii) only at particular locations within Lascaux. Scanning electron microscopy observations and most qPCR data evidenced microbial proliferation in dark zones.ConclusionFindings point to the proliferation of different types of taxa in dark zones, i.e. Lascaux-cosmopolitan bacteria and fungi, dark zone-specific bacteria present at all locations, and dark zone-specific bacteria and fungi present at certain locations only. This probably explains why dark zones could form in various areas of the cave and suggests that the spread of these alterations might continue according to the area of distribution of key widespread taxa.
Effect of various parameters on the performance of solar PV power plant: a review and the experimental study
Authors: Shaik Feroz , Lingala Syam Sundar , Veeraboina Punnaiah 
Published: April 2023

AbstractOne of the biggest causes of worldwide environmental pollution is conventional fossil fuel-based electricity generation. The need for cleaner and more sustainable energy sources to produce power is growing as a result of the quick depletion of fossil fuel supplies and their negative effects on the environment. Solar PV cells employ solar energy, an endless and unrestricted renewable energy source, to generate electricity directly. The optimum output, energy conversion efficiency, productivity, and lifetime of the solar PV cell are all significantly impacted by environmental factors as well as cell operation and maintenance, which have an impact on the cost-effectiveness of power generation. This article presents an analysis of recent research on the impact of operational and environmental factors on the performance of solar PV cells. It has been discovered that temperature and humidity, combined with dust allocation and soiling effect, have a significant impact on the performance of PV modules. In addition, particularly in the lonely places, the wind itself carries a lot of dust and sand particles. The situation gets worse when dust builds up in humid circumstances and produces tenacious, sticky mud on the PV cell, which lowers power output by up to 60–70%. This paper covers cutting-edge methods for reducing these elements’ effects, along with their proportional benefits and difficulties. This paper also explains about the parameters which involved in the solar power production and their influence on the efficiency analysis. The efficiency and energy conversion capacity of the semi conducting materials for power production is also discussed. It is also discussed about the general benefits of the solar PV power generation.
Researchers’ experiences with patient engagement in health research: a scoping review and thematic synthesis
Authors: Pratte Marie-Mychèle , Audette-Chapdelaine Sophie , Auger Anne-Marie , Wilhelmy Catherine , Brodeur Magaly 
Published: April 2023

AbstractContextImplicating patients in research is gaining popularity around the world and is now the reference of many funding agencies. Understanding these partnerships is necessary to grasp this new reality. The experiences of researchers who have involved patient-partners (PPs) in health research are important for a better understanding of these practices.ObjectiveThis study aimed to identify and analyze the existing qualitative scientific literature on the experiences of academic researchers involved in health research with patient engagement (PE).DesignA scoping review of the available literature with an inductive thematic synthesis, guided by the methodological framework of Arksey and O’Malley.Data collectionA search strategy was developed to include keywords relating to researchers, patient-partners, experiences, and the qualitative methodologies of the targeted studies. Five databases were searched using the EBSCO-host engine. The search results were screened by four reviewers to only include articles written in English on the topic of the experience of academic researchers having worked with PPs in health research based on qualitative studies or mixed-methods studies with a distinct qualitative section.AnalysisArticles included were charted for general information. All “results” sections were coded line by line. These codes were organized inductively to form descriptive and analytical themes. This led to the synthesis of the ideas found in the selected articles.ResultsThe search strategy yielded 7616 results, of which 2468 duplicates were removed. The remaining 5148 articles were screened, resulting in the exclusion of 5114 off-topic studies. The remaining 29 full-text articles were evaluated for inclusion from which 5 additional studies were identified. The final selection consisted of 11 articles that met all the criteria. These articles were published between 2009 and 2019. Five general themes inductively emerged from the analysis: the understanding of PE, motivations, contexts, attitudes, and practical aspects of PE that are central to researchers.ConclusionThis scoping review provides a better understanding of the experiences of researchers who have implemented patient partnerships in health research projects. Our findings reveal many positive elements central to health researchers’ discourses about PE, but they provide insights into the challenges and postures of resistance. This knowledge can support the development of empirically sound improvements in PE practices.
Dose-response association between dietary folate and niacin intakes with diabetes among Chinese adults: a cross-sectional study
Authors: Jiang Yuhong , Zhang Zhiwen , Zhu Yi , Chai Yongfei , Xie Hong 
Published: April 2023

Abstract
Background
The aim of this study was to examine the relationship between dietary intake of folate and niacin and diabetes risk in Chinese adults.

Methods
This is a cross-sectional study. Demographic and anthropometric data along with information on dietary intake of vitamins were collected, and eligible participants were recruited to complete the questionnaire. A binary logistic regression analysis was conducted to examine the association between dietary intake of vitamins and diabetes risk, with adjustment for potential confounders. Non-linear dose-response relationships between dietary intake of folate and niacin and diabetes risk were also evaluated using adjusted restricted cubic splines.

Results
Of the 3106 eligible participants, 15.9% had diabetes. Median folate was significantly higher in diabetic patients than in controls (32.030 vs. 27.600 gμ), while median niacin was significantly lower (7.000 vs. 7.900 mg). After controlling for potential confounders, binary logistic regression analysis showed that each unit increase in folate intake was associated with a 1.002-fold increase in the risk of developing diabetes (odds ratio (OR) = 1.002; 95% confidence interval (CI) 1.000–1.004; P = 0.022), while each unit increase in niacin intake was associated with a 3.5% reduction in diabetes risk (OR = 0.965; 95% CI 0.944–0.986; P = 0.001). The plots of restricted cubic splines presented an atypical inverted U-shaped association between dietary intake of folate and diabetes risk.

Conclusions
Diabetic patients had a low intake of vitamins, especially the B vitamins. Dietary intake of folate and niacin tended to be independently associated with the risk of diabetes. Nevertheless, this study is observational and a large-scale randomized controlled trial is yet to be conducted, which will add to the evidence of the study results.
Modified pressure-cooker technique (PCT) using extra-soft Kaneka coils improves embolization of high-grade cerebral arteriovenous malformations: a technical note
Authors: Yüksel Mahmut , Psychogios Marios , Blackham Kristine 
Published: April 2023

AbstractEndovascular embolization techniques are showing an extraordinary potential to treat patients suffering from complex neurovascular malformations. The embolization with liquid embolic agents via Onyx is a prominent approach to treat arteriovenous malformation (AVM). However, intraoperative reflux of the liquid agents can be very challenging and, thus, is impairing full success of endovascular treatment. A possible technique to prevent intraoperative endovascular reflux is the pressure-cooker technique (PCT) utilizing coils to build a wedge proximal to the AVM. Few modifications of the PCT have been developed in the recent years to improve effectiveness of embolization procedure. Hereby, we present a novel PCT modification utilizing extra-soft Kaneka coils and glue to build well-fitting wedges. After the application of extremely soft bare coils with high trackability, flexibility and crossability, liquid agents can be injected with reduced reflux. We think the pressure-cooker technique with extra-soft Kaneka coils enables more efficient embolization in even farther, tinier and more tortuous target vessels. This technical note presents two illustrative patient cases with treatment-refractory, high-grade cerebral arteriovenous malformations which were successfully treated via embolization with PCT in which the plug was formed with Kaneka coils.
Articulating spacers: what are available and how to utilize them?
Authors: Li Zhuo , Xu Chi , Chen Jiying 
Published: April 2023

AbstractPeriprosthetic joint infection (PJI) is the most devastating complication following total joint arthroplasty (TJA) and is posing a global healthcare challenge as the demand for TJA mounts. Two-stage exchange arthroplasty with the placement of antibiotic-loaded spacers has been shown to be efficacious against chronic PJI. This study aimed to review the key concepts, types, and outcome evaluations of articulating spacers in the two-stage exchange for PJI. Previous studies indicated that articulating spacers have been widely used due to better functional improvement and a comparable infection control rate relative to static spacers. Several types of articulating spacers are reportedly available, including hand-made spacers, spacers fashioned from molds, commercially preformed spacers, spacers with additional metal or polyethylene elements, new or autoclaved prosthesis, custom-made articulating spacers, and 3D printing-assisted spacers. However, limited evidence suggested no significant difference in clinical outcomes among the different subtypes of articulating spacers. Surgeons should be familiar with different treatment strategies when using various spacers to know which is the most appropriate.
Network and functional analyses of differentially expressed genes in gastric cancer provide new biomarkers associated with disease pathogenesis
Authors: Fadaei Mousa , Kohansal Maryam , Akbarpour Omidreza , Sami Mahsa , Ghanbariasad Ali 
Published: April 2023

AbstractBackgroundGastric cancer is a dominant source of cancer-related death around the globe and a serious threat to human health. However, there are very few practical diagnostic approaches and biomarkers for the treatment of this complex disease.MethodsThis study aimed to evaluate the association between differentially expressed genes (DEGs), which may function as potential biomarkers, and the diagnosis and treatment of gastric cancer (GC). We constructed a protein-protein interaction network from DEGs followed by network clustering. Members of the two most extensive modules went under the enrichment analysis. We introduced a number of hub genes and gene families playing essential roles in oncogenic pathways and the pathogenesis of gastric cancer. Enriched terms for Biological Process were obtained from the “GO” repository.ResultsA total of 307 DEGs were identified between GC and their corresponding normal adjacent tissue samples in GSE63089 datasets, including 261 upregulated and 261 downregulated genes. The top five hub genes in the PPI network were CDK1, CCNB1, CCNA2, CDC20, and PBK. They are involved in focal adhesion formation, extracellular matrix remodeling, cell migration, survival signals, and cell proliferation. No significant survival result was found for these hub genes.ConclusionsUsing comprehensive analysis and bioinformatics methods, important key pathways and pivotal genes related to GC progression were identified, potentially informing further studies and new therapeutic targets for GC treatment.
Neuro-nutraceuticals: Insights of experimental evidences and molecular mechanism in neurodegenerative disorders
Authors: Wal Pranay , Aziz Namra , Dash Biswajit , Tyagi Sachin , Vinod Yadav Rupali 
Published: April 2023

Abstract
Background
One of the most important healthcare challenges in the world today is neurological disorders. Pose lifestyle changes are linked to a significantly higher risk of chronic illnesses and diseases, placing a significant financial and healthcare burden on society at large. In this review article, we focused on the various neuro-nutraceutical herbs and their beneficial roles in neurodegenerative disorders.

Main body of the abstract
An extensive literature review was done from the standard databases such as Scopus, Elsevier, and PubMed using standard keywords “Nutraceuticals”, “Neuro-nutraceuticals”, “Neurodegenerative disorders”. Numerous "neuro-nutraceuticals" are natural plant compounds with dietary and pharmaceutical components that are intended to improve cerebral blood flow along with illness prevention and control. These compounds are found in food, herbal medicines, and nutritional supplements such as Bacopa monnieri, Curcuma longa, Asparagus racemosus, Helicteres angustifolia, Hericium erinaceus, Crocus sativus, Uncaria tomentosa, Centella asiatica, Convolvulus pluricaulis, Moringa oleifera.

Short conclusion
While discussing the neuroprotective and the neuromodulatory properties of various neuro-nutraceuticals, we rationally postulate here their molecular mechanisms. Additionally, compared to single-target medicines, which may have unfavourable side effects, these herbs are believed to be safer and to provide a more holistic improvement in brain health.

Graphical Abstract
Effect of Red Blood Cell Transfusion on Regional Tissue Oxygenation in Pediatric Cardiac Surgery Patients
Authors: Surma Victoria J. , Patel Ankur , Ng Derek K. , Goswami Dheeraj K. , Garcia Alejandro V. , Bembea Melania M. 
Published: April 2023

BACKGROUND:
Red blood cell (RBC) transfusions are used frequently in pediatric patients admitted to the intensive care unit (ICU) after cardiac surgery. To improve data-driven transfusion decision-making in the ICU, we conducted a retrospective analysis to assess the effect of RBC transfusion on cerebral and somatic regional oxygenation (rSO2).

METHODS:
We evaluated post- versus pre-RBC transfusion cerebral rSO2 and somatic rSO2 in all consecutive pediatric patients (age >28 days to <18 years) who underwent biventricular cardiac surgery at a single center between July 2016 and April 2020.

RESULTS:
The final data set included 263 RBC postoperative transfusion events in 75 patients who underwent 83 surgeries. The median pretransfusion hemoglobin was 10.6 g/dL (25th–75th percentile, 9.3–11.6). The median pretransfusion cerebral and somatic rSO2 were 63% (54–71) and 69% (55–80), which increased by a median of 3 percentage points (–2 to 6) and 2 percentage points (–3 to 6), respectively, after transfusion. After adjusting for pretransfusion hemoglobin, change in hemoglobin posttransfusion versus pretransfusion, and potential confounders (age, sex, and STAT surgical mortality risk score), the posttransfusion versus pretransfusion change in cerebral or somatic rSO2 was not statistically significant. Pretransfusion cerebral rSO2 (crSO2) was ≤50%, a previously described threshold for increased risk for unfavorable neurological outcome, for 22 of 138 (16%) transfusion events with complete pre- and post-crSO2 data. Sixteen of these 22 (73%) transfusions resulted in a posttransfusion crSO2 >50%. When restricting analysis to the first (index) transfusion after arrival to the ICU from the operating room (administered at a median of 1.15 postoperative days [25th–75th percentile, 0.84–1.93]), between-patient pretransfusion hemoglobin was not associated with pretransfusion crSO2 but within-patient posttransfusion versus pretransfusion hemoglobin difference was significantly associated with posttransfusion versus pretransfusion crSO2 difference (mean posttransfusion versus pretransfusion crSO2 difference, 2.54; 95% confidence interval, 0.50–4.48).

CONCLUSIONS:
In this study, neither cerebral nor somatic rSO2 increased significantly post- versus pre-RBC transfusion in pediatric cardiac surgery patients admitted to the ICU after biventricular repairs. However, almost three-quarters of transfusions administered when pretransfusion crSO2 was below the critical threshold of 50% resulted in a posttransfusion crSO2 >50%. In addition, the significant within-patient change in crSO2 in relation to the change in posttransfusion versus pretransfusion hemoglobin in the immediate postoperative period suggests that a personalized approach to transfusion following within-patient trends of crSO2 rather than absolute between-patient values may be an important focus for future research.
When Lightning Strikes: Sports and Recreational Activities Safety
Authors: Bauer Alison K. , Golden Krystyna G. , Colvin Christopher M. , Lammlein Kyle P. , Wise Sean R. 
Published: April 2023

Abstract
Lightning strikes and their sequela are well-known sources of injury associated with sports and outdoor activities. While mortality is relatively rare and has steadily decreased over the years, the potentially catastrophic effects make knowledge about lightning strike injuries continually relevant. The primary focus of lightning-related safety is prevention and newer literature over the last 2 years has been largely case reports. Attempts to reduce lightning-related injuries in outdoor sports have been made with easily recalled guidelines by the National Athletic Trainers' Association, as well as the National Collegiate Athletic Association. Newer technology related to lightning safety uses digital and app-based monitoring systems to aid in injury prevention strategies. Occupational lightning exposure continues to be a hazard, especially for those who work outdoors, including certain military personnel. Service members, athletes, and outdoor enthusiasts should remain vigilant, especially during times with higher likelihood of lightning strikes.