bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entre la filosofía del diálogo y el dolor schopenhaueriano: el peligro del devenir de la nada
Authors: León Pacheco Roberto Julio 
Published: April 2023

La pandemia en el Perú ha agudizado diversas carencias y ha desnudado otras ocultas por años. El dolor que viene siendo experimentado por el mundo y nuestro amado país no tiene precedentes. Intentamos en el presente documento relacionar y reflexionar sobre el dolor y la filosofía del diálogo aproximándonos a la coyuntura del bicentenario.
En el ámbito del diálogo, la reflexión sobre la incapacidad a la apertura ante múltiples oportunidades se hace necesaria. El hombre occidental, por un lado, no ha podido incorporar, en su devenir histórico, otras opciones a las planteadas por la modernidad; de otro lado, el narcisismo se asoma como riesgo para el despliegue del diálogo.
Si bien Schopenhauer revalora el dolor como factor purificador y productor de desengaño, la revalorización entra en conflicto cuando el dolor no termina. La apertura, entonces, es un punto de inicio, esperanzador y relevante, de la socialidad.
Este trabajo sustenta la idea de que el diálogo sin apertura hacia el otro, bajo una concepción occidental del mundo y en una sociedad narcisista está condenado a una purificación al estilo schopenhaueriano y a un devenir de la nada.
Palabras clave: diálogo, dolor, devenir, apertura, filosofía

Abstract
The pandemic in Peru has exacerbated several deficiencies and has revealed others that have been hidden for years. The pain being experienced by the world and our beloved country is unprecedented. In this article, we try to relate and reflect on the pain and the philosophy of dialogue approaching the bicentennial.

In the context of dialogue, reflection on the inability to be open to multiple opportunities becomes necessary. The Western man, on the one hand, has not been able to incorporate, in his historical evolution, other options to those proposed by modernity; on the other hand, narcissism appears as a risk for the unfolding of dialogue.
Although Schopenhauer revalues pain as a purifying factor and producer of disillusionment, the revaluation enters into conflict when pain does not end. Openness, then, is a hopeful and relevant starting point for sociality.
This work supports the idea that dialogue without openness towards the other, under a Western conception of the world and in a narcissistic society, is condemned to a Schopenhauerian- style purification and a becoming of nothingness.
Keywords: dialogue, pain, future, openness, philosophy
ilusión abandonada. José de la Riva-Agüero y Mario Vargas Llosa, los intelectuales conversos y la derecha peruana
Authors: Gonzales Alvarado Osmar 
Published: April 2023

En este artículo, el autor realiza una rápida evaluación de algunas de las ideas de la derecha sobre el Perú para tratar de entender sus cambios profundos. Para ello toma a dos personajes referenciales: el historiador limeño José de la Riva-Agüero y el escritor arequipeño Mario Vargas Llosa. La idea central que recorre estas páginas es que la derecha ha abandonado la preocupación por la nación para priorizar su inserción en la globalización, aun cuando sea ocupando un papel secundario o irrelevante en el escenario mundial.
Palabras clave: Intelectuales, ideología, nación, globalización, conservadurismo, derecha peruana.

Abstract

In this article, the author makes a quick evaluation of some of the ideas of the right about Peru to try to understand its profound changes. O do this, he takes two referential characters: the Lima historian José de la Riva-Agüero and the Arequipa writer Mario Vargas Llosa. He central idea that runs through these pages is that the right has abandoned concern for the nation to prioritize its insertion into globalization, even when it is occupying a secondary or irrelevant role on the world stage.
Keywords: Intellectuals, ideology, nation, globalization, conservatism, peruvian right.
Vallejo Agonista entre dos culturas. Notas a partir de algunas crónicas vallejianas
Authors: Sandoval Bacigalupo Renato 
Published: April 2023

Menos conocida que su labor poética fue la actividad periodística y ensayística que el poeta ejerció en Europa. Sus reflexiones giraron, sobre todo, en torno a las tensiones entre el mundo americano y el europeo; el lúcido vaticinio del renacer artístico en el caso del primero y las críticas a la bohemia insustancial del segundo.
Palabras clave: Europa, Latinoamérica, bohemia, crisis sociocultural y política, Rusia, España, solidaridad, integración.

Abstract

His journalistic and essayistic activity in Europe was less well known than his poetic work. His reflections revolved, above all, around the tensions between the American and European worlds; the lucid prediction of the artistic revival in the case of the former and the criticism of the insubstantial bohemianism of the second.
Keywords: Europe, Latin America, bohemia, socio-cultural and political crisis, Russia, Spain, solidarity, integration.
Konseptual Desain Pesawat UAV Meniru Cessna 172 Dengan Konfigurasi Sayap Morphing Untuk Misi Trainer
Authors: Fadhilah Mizan , Mas Intan Haqqah Risath 
Published: April 2023

Perkembangan UAV/drone di Indonesia sedang berkembang pesat terbukti banyak UAV/drone buatan dalan negeri, karena memang keberadaan drone ini dapat membantu tugas manusia dalam bidang tertentu, maka dari itu peneliti tertarik untuk membuat desain konsep UAV untuk keperluan misi trainer dengan konfigurasi sayap morphing yang akan diperuntukkan untuk pilot pemula sebagai syarat untuk memperoleh sertifikasi pilot drone. Dengan menggunakan perhitungan menggunakan metode Anderson didapatkan luaran perhitungan yang akan dijadikan sebagai acuan dalam penyusunan dan manufaktur konseptual desain pesawat yang akan di dibuat. Didapat estimasi berat awal pesawat UAV meniru Cessna 172 dengan konfigurasi sayap morphing untuk keperluan misi trainer sebesar 5,375433 lb dengan panjang fuselage 5,15304 ft, dan bentang sayap sebesar 5,266345 ft yang diposisikan di atas fuselage, serta ditenagai oleh 1 engine motor brushless sebesar 0,129642 hp.
ОСОБЛИВОСТІ ЕКСПЕРТНОГО ПСИХОЛОГІЧНОГО КОНСУЛЬТУВАННЯ В ОСВІТНІХ ЗАКЛАДАХ
Authors: ПЕТЯК Олена , ОКСЮТОВИЧ Марина 
Published: April 2023

У статті розглядається питання експертного психологічного консультування в закладах загальної середньої освіти та вищих навчальних закладах. Визначено загалом поняття експертного психологічного консультування. Представлені чотири основні підходи до експерт-консультування: 1) базується на концепції психічного здоров’я; 2) адлеріанський; 3) біхевіоральний; 4) заснований на концепції організаційного розвитку. Здійснений огляд основних рівнів експерт-консультацій в закладах освіти в рамках первинної профілактики та розглянуті особливості щодо позитивного впливу на експертні консультування психологів в освітніх закладах.
Blood Kallikrein-8 and Non-Amnestic Mild Cognitive Impairment: An Exploratory Study
Authors: Schramm Sara , Krizanovic Nela , Roggenbuck Ulla , Jöckel Karl-Heinz , Herring Arne , Keyvani Kathy , Jokisch Martha 
Published: April 2023

Background: Blood kallikrein-8 is supposed to be a biomarker for mild cognitive impairment (MCI) due to Alzheimer’s disease (AD), a precursor of AD dementia. Little is known about the association of kallikrein-8 and non-AD type dementias. Objective: To investigate whether blood kallikrein-8 is elevated in individuals with non-amnestic MCI (naMCI), which has a higher probability to progress to a non-AD type dementia, compared with cognitively unimpaired (CU) controls. Methods: We measured blood kallikrein-8 at ten-year follow-up (T2) in 75 cases and 75 controls matched for age and sex who were participants of the population-based Heinz Nixdorf Recall study (baseline: 2000–2003). Cognitive performance was assessed in a standardized manner at five (T1) and ten-year follow-up. Cases were CU or had subjective cognitive decline (SCD) at T1 and had naMCI at T2. Controls were CU at both follow-ups. The association between kallikrein-8 (per 500 pg/ml increase) and naMCI was estimated using conditional logistic regression: odds ratios (OR) and 95% confidence intervals (95% CI) were determined, adjusted for inter-assay variability and freezing duration. Results: Valid kallikrein-8 values were measured in 121 participants (45% cases, 54.5% women, 70.5±7.1 years). In cases, the mean kallikrein-8 was higher than in controls (922±797 pg/ml versus 884±782 pg/ml). Kallikrein-8 was not associated with having naMCI compared to being CU (adjusted; OR: 1.03 [95% CI: 0.80–1.32]). Conclusion: This is the first population-based study that shows that blood kallikrein-8 tends not to be elevated in individuals with naMCI compared with CU. This adds to the evidence of the possible AD specificity of kallikrein-8.
Contrast Enhanced Magnetic Resonance Imaging of Amyloid-β Plaques in a Murine Alzheimer’s Disease Model
Authors: Sulheim Einar , WiderØe Marius , Bäck Marcus , Nilsson K. Peter R. , Hammarström Per , Nilsson Lars N.G. , Davies Catharina de Lange , Åslund Andreas K.O. 
Published: April 2023

Background: Early detection of amyloid-β (Aβ) aggregates is a critical step to improve the treatment of Alzheimer’s disease (AD) because neuronal damage by the Aβ aggregates occurs before clinical symptoms are apparent. We have previously shown that luminescent conjugated oligothiophenes (LCOs), which are highly specific towards protein aggregates of Aβ, can be used to fluorescently label amyloid plaque in living rodents. Objective: We hypothesize that the LCO can be used to target gadolinium to the amyloid plaque and hence make the plaque detectable by T1-weighted magnetic resonance imaging (MRI). Methods: A novel LCO-gadolinium construct was synthesized to selectively bind to Aβ plaques and give contrast in conventional T1-weighted MR images after intravenous injection in Tg-APPSwe mice. Results: We found that mice with high plaque-burden could be identified using the LCO-Gd constructs by conventional MRI. Conclusion: Our study shows that MR imaging of amyloid plaques is challenging but feasible, and hence contrast-mediated MR imaging could be a valuable tool for early AD detection.
Change in the Quick Dementia Rating System Across Time in Older Adults with and without Cognitive Impairment
Authors: Duff Kevin , Wan Laura , Embree Lindsay , Hoffman John M. 
Published: April 2023

Background: The Quick Dementia Rating System (QDRS) is a brief, informant-reported dementia staging tool that approximates scores on the Clinical Dementia Rating Scale in patients with Alzheimer’s disease (AD). Objective: The current study sought to examine change in the QDRS across time, which is necessary for clinical and research efforts. Methods: One-hundred ten older adults (intact, mild cognitive impairment [MCI], mild AD, classified with Alzheimer’s Disease Neuroimaging Initiative criteria) were rated on the QDRS by an informant and had an amyloid positron emission tomography scan at baseline. The informant re-rated each participant on the QDRS after one year. Dependent t-tests compared the entire sample and various subgroups (e.g., cognitive status, amyloid status) on baseline and follow-up QDRS scores. Results: In the entire sample, the Total score on the QDRS significantly increased (i.e., worsened) on follow-up ( p < 0.001). When subgroups were analyzed, the MCI and mild AD subjects showed increasing (i.e., worsening) QDRS Total scores (both p < 0.001), but the intact subjects remained stable over time ( p = 0.28). Additionally, those classified as being amyloid positive at baseline showed significantly increased QDRS Total scores at follow-up ( p < 0.001) compared to those who were amyloid negative at baseline, whose QDRS Total scores remained stable over time ( p = 0.63). Conclusion: The QDRS can potentially demonstrate worsening functioning status across one year, especially in those who have MCI or mild AD and those who are amyloid positive. Therefore, the current results preliminarily suggest that the QDRS may provide an efficient tool for tracking progression in clinical trials in AD.
Video images compression method based on floating positional coding with an unequal codograms length
Authors: Barannik Vladimir , Sidchenko Serhii , Barannik Dmitriy , Yermachenkov Andrii , Savchuk Maksym , Pris Gennady 
Published: April 2023

The subject of research in the article are the video images compression and encryption processes during the critically important objects managing process. The goal is to develop a method for compressing video images based on floating positional coding with an uneven codegrams length to simultaneously ensure information reliability and confidentiality during its transmission with a given time delay. Objectives: analyzing existing approaches to ensuring the video images confidentiality; development a method for compressing video images based on floating positional coding with an uneven codegrams length; evaluate the developed method effectiveness. The methods used are: digital image processing methods, digital image compression methods, image encryption and scrambling methods, structural-combinatorial coding methods, statistical analysis methods. The following results are obtained. The technology of floating encoding of an uneven sequence of blocks is proposed. Code values are formed from elements of different video image blocks. For this, a scheme for linearizing an image point coordinates from its four-dimensional representation on a plane into a one-dimensional element coordinate in a vector has been developed. The four-dimensional element coordinate on the plane describes the image block coordinates and the coordinates of the element in this block. Code values are formed under conditions of control their binary representation's length. At the same time, coding is implemented for an indeterminate number of video image elements. The number of elements depends on the length of the code word. Accordingly, codegrams with an indeterminate length are formed. Their length depends on the service data values, generated during the encoding process. Service data acts as a key element. Conclusions. The one-stage polyadic image encoding method in a differentiated basis has been further improved. The developed encoding method provides image compression without information quality loss. The original images volume compression provides by 3–20 % better compared to the TIFF data presentation format and by 4–15 % compared to the PNG format. The overhead amount is less than 2.5 % of the entire codestream size.
ANALISA DAYA DUKUNG TANAH UNTUK PONDASI BORED PILE DI TITIK ABT 1+573 DAN ABT 1+838 DALAM PROYEK JEMBATAN KERETA API LAYANG MEDAN-BINJAI
Authors: Syukri Muhammad , Amiruddin Feri , Siregar Chandra Afriade 
Published: April 2023

Analisis daya dukung tanah untuk pondasi merupakan suatu pekerjaan yang sangat penting dalam suatu pekerjaan teknik sipil, karena analisis pondasi inilah yang menjadi inti perhitungan pondasi dalamÂ memikul dan menahan suatu beban yang bekerja diatasnya yaitu beban konstruksi atas. Tujuan dari studi ini untuk menghitung kuat dukung tiang bored pile dari hasil sondir (CPT) dan standar penetrasi test (SPT) kemudian membandingkan hasil kuat dukung tiang bored pile. Metode perhitungan kuat dukung untuk data sondir menggunakan metode Aoki dan Reese dan metode Meyerhoff, untuk data SPT menggunakan metode Reese dan wright dan metode Meyerhoff.
KAJIAN BETON POROUS DENGAN MENGGUNAKAN VARIAN GRADASI AGREGAT KASAR DAN SILICA FUME UNTUK PENGUJIAN KUAT TEKAN DAN TARIK BELAH BETON
Authors: Zalalludin Muhamad Rifa'i , Ryanto Muhamad 
Published: April 2023

Pembuatan beton porous dengan bahan tambah silica fume sebesar 3%, digunakan 3 varian ukuran gradasi agregat kasar (agregat yang tertahan di ayakan 4,75mm , 9,5mm dan 12,5mm). Dimensi benda uji dibuat dalam bentuk silinder ukuran 15cm x 30cm. Pengujian yang dilakukan , kuat Tekan Beton dan Kuat Tarik Belah Beton. Pengujian dilakukan pada umur beton 28 hari. Penelitian dibuat 18 benda uji, BPTK 1 (4,75mm) 3 bh , BPTK 2 (9,5mm) 3 bh, BPTK 3 (12,5mm) 3 bh. BPTR 1 (4,75mm) 3 bh, BPTR 2 (9,5mm) 3 bh dan BPTR 3 (12,5mm) 3 bh. Penelitian ini digunakan perbandingan campuran beton 1 : 4 (semen : agregat kasar) dan w/c 0,34%. Hasil kuat tekan rata-rata benda uji BPTK 1-3 (11,01 MPa), BPTK 2 (9,10 MPa) dan BPTK 3 (7,76 MPa). Hasil kuat tarik belah benda uji BPTR 1 (1,32 MPa), BPTR 2 (0,94 MPa) dan BPTR 3 (0,71 MPa). Penurunan nilai kuat tekan.BPTK 1 ke BPTK 2 sebesar (17,40%) dan BPTK 2 ke BPTK 3 sebesar (14,65%). Penurunan nilai kuat tarik belah dari BPTR 1 ke BPTR 2 sebesar (28,57%) dan BPTR 2 ke BPTR 3 sebesar (25,00%). Nilai persen rongga BPTK 1 (30,56%), BPTK 2 (32,88%) dan BPTK 3 (34,38%). Nilai persen rongga BPTR 1 (30,56%), BPTR 2 (32,88%) dan BPTR 3 (34,38%). Rata-rata berat jenis benda uji 1.821,88 Kg/m3.
PERENCANAAN FONDASI BORED PILE DENGAN MENGGUNAKAN SOFTWARE GROUP PILE BERDASARKAN DATA SPT (Studi Kasus Pembangunan Jembatan Tendeki Ruas Jalan Tol Manado – Bitung Seksi II)
Authors: Abdarraafi Farid Darulhanif , Siregar Chandra Afriade 
Published: April 2023

Dalam melakukan pekerjaan soil test yang berlokasi di Jembatan Tendeki Ruas Jalan Tol Manado – Bitung Seksi II, Sulawesi Utara, Untuk melihat kondisi tanah di lapangan dilakukan cara penyelidikan tanah langsung di lapangan (Field Soil Investigation). Data yang diperoleh dari hasil pengujian akan dipergunakan sebagai dasar untuk pekerjaan konstruksi fondasi atau konstruksi yang berhubungan dengan Geoteknik. Dari hasil analisis perencanaan fondasi bored pile, maka diperoleh desain fondasi sebagai berikut: Pertama, Pier 4, Diameter 1.20 m dan Panjang tiang 15 m. 1) Memiliki beban struktur atas 79854 kN, menggunakan konfigurasi 32 tiang dengan nilai daya dukung kelompok 89103.2 kN dan nilai axial dari software group pile yaitu 80371 kN. 2) Dengan konfigurasi 32 tiang dan Panjang tiang 15 m, memiliki volume 16.965 untuk tiang tunggal dan total volume keseluruhan yaitu 542.867 Kedua, Pier 5, Diameter 1.20 m dan Panjang tiang 20 m. 1) Memiliki beban struktur atas 79439 kN, menggunakan konfigurasi 24 tiang dengan nilai daya dukung kelompok 84677.4 kN dan nilai axial dari software group pile yaitu 79464.1 kN. 2) Dengan konfigurasi 24 tiang dan Panjang tiang 20 m, memiliki volume 22.619 untuk tiang tunggal dan total volume keseluruhan yaitu 542.867
Case report: Fulminant type 1 diabetes following paucisymptomatic SARS-CoV-2 infection during late pregnancy
Authors: Zhou Lingling , Qu Huanjia , Zhang Qiuling , Hu Jinhua , Shou Lan 
Published: April 2023

BackgroundDysregulation of glucose metabolism has been linked to SARS-CoV-2 infection. In addition, the occurrence of new onset diabetes mellitus, including fulminant type 1 diabetes, has been reported after SARS-CoV-2 infection or vaccination.Methods and resultsA young Chinese woman in her last trimester of pregnancy presented with an abrupt progression of hyperglycemia and ketoacidosis, but with a near-normal glycohemoglobin level following paucisymptomatic SARS-CoV-2 infection. The low C peptide levels, both fasting and postprandial, reflected profound insulin deficiency in the setting of negative islet autoantibody testing, consistent with a diagnosis of fulminant type 1 diabetes. Ketoacidosis and hyperglycemia quickly improved following the introduction of insulin therapy, but not the β cell function. The patient received treatment with insulin pump therapy after being discharged, and the first follow-up revealed a well-controlled glucose profile.ConclusionsNew-onset FT1D can occur after SARS-CoV-2 infection. Our report raises awareness of this rare but serious situation, promoting early recognition and management of FT1D during the COVID-19 pandemic.
Identification and characterization of bone/cartilage-associated signatures in common fibrotic skin diseases
Authors: Wu Ting , Jin Yifan , Chen Fangqi , Xuan Xiuyun , Cao Juanmei , Liang Yan , Wang Yuqing , Zhan Jinshan , Zhao Mengjie , Huang Changzheng 
Published: April 2023

Background: Fibrotic skin diseases are characterized by excessive accumulation of the extracellular matrix (ECM) and activation of fibroblasts, leading to a global healthcare burden. However, effective treatments of fibrotic skin diseases remain limited, and their pathological mechanisms require further investigation. This study aims to investigate the common biomarkers and therapeutic targets in two major fibrotic skin diseases, namely, keloid and systemic sclerosis (SSc), by bioinformatics analysis.Methods: The keloid (GSE92566) and SSc (GSE95065) datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified, followed by functional enrichment analysis using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). We then constructed a protein–protein interaction (PPI) network for the identification of hub genes. We explored the possibility of further functional enrichment analysis of hub genes on the Metascape, GeneMANIA, and TissueNexus platforms. Transcription factor (TF)–hub gene and miRNA–hub gene networks were established using NetworkAnalyst. We fixed GSE90051 and GSE76855 as the external validation datasets. Student’s t-test and receiver operating characteristic (ROC) curve were used for candidate hub gene validation. Hub gene expression was assessed in vitro by quantitative real-time PCR.Results: A total of 157 overlapping DEGs (ODEGs) were retrieved from the GSE92566 and GSE95065 datasets, and five hub genes (COL11A1, COL5A2, ASPN, COL10A1, and COMP) were identified and validated. Functional studies revealed that hub genes were predominantly enriched in bone/cartilage-related and collagen-related processes. FOXC1 and miR-335-5p were predicted to be master regulators at both transcriptional and post‐transcriptional levels.Conclusion: COL11A1, COL5A2, ASPN, COL10A1, and COMP may help understand the pathological mechanism of the major fibrotic skin diseases; moreover, FOXC1 and miR-355-5p could build a regulatory network in keloid and SSc.