bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent advances in physical treatments of papaya fruit for postharvest quality retention: A review
Authors: Vinod B. R. , Asrey Ram , Sethi Shruti , Prakash Jai , Meena Nirmal Kumar , Menaka M. , Mishra Shatakashi , Shivaswamy Gouthami 
Published: March 2023

AbstractPapaya is a luscious tropical fruit loaded with vitamins and phytochemicals. The climacteric nature of fruit exposes it to numerous postharvest pathogens. Postharvest physical treatments are safer and greener approaches to mitigate the losses and bridge the gap between demand and supply of fruit. These treatments preserve the fruit quality during extended periods of cold storage and maintain shelf life. Nonetheless, prestorage physical treatments can positively impact the postharvest food value of fresh papaya fruits. This review summarizes the major advances in the field of postharvest physical treatments on papaya postharvest quality. Physical treatments include ozonation, irradiation, thermal and low‐temperature treatment, and synergistic effect among different physical treatments and also the synergetic effect of physical treatments with chemicals, essential oils, and coating materials on quality retention and disease management. The potential physiological, biochemical, microbiological, enzymatic, and biotechnological mechanisms of different physical treatments are reviewed. The review primarily highlights the changes induced due to physical treatment on genetic, biochemical, and physicochemical properties of papaya fruit. Most treatments positively impact the esthetic and nutritional value of fruit by reducing disease severity, physiological loss in weight, preserving physicochemical attributes, and retaining natural gloss and color. Use of physical interventions in papaya vouch for a safer, sustainable, and premium quality produce in the global market.
Remote effects of temporal lobe epilepsy surgery: Long‐term morphological changes after surgical resection
Authors: Arnold T. Campbell , Kini Lohith G. , Bernabei John M. , Revell Andrew Y. , Das Sandhitsu R. , Stein Joel M. , Lucas Timothy H. , Englot Dario J. , Morgan Victoria L. , Litt Brian , Davis Kathryn A. 
Published: March 2023

AbstractObjectiveEpilepsy surgery is an effective treatment for drug‐resistant patients. However, how different surgical approaches affect long‐term brain structure remains poorly characterized. Here, we present a semiautomated method for quantifying structural changes after epilepsy surgery and compare the remote structural effects of two approaches, anterior temporal lobectomy (ATL), and selective amygdalohippocampectomy (SAH).MethodsWe studied 36 temporal lobe epilepsy patients who underwent resective surgery (ATL = 22, SAH = 14). All patients received same‐scanner MR imaging preoperatively and postoperatively (mean 2 years). To analyze postoperative structural changes, we segmented the resection zone and modified the Advanced Normalization Tools (ANTs) longitudinal cortical pipeline to account for resections. We compared global and regional annualized cortical thinning between surgical treatments.ResultsAcross procedures, there was significant cortical thinning in the ipsilateral insula, fusiform, pericalcarine, and several temporal lobe regions outside the resection zone as well as the contralateral hippocampus. Additionally, increased postoperative cortical thickness was seen in the supramarginal gyrus. Patients treated with ATL exhibited greater annualized cortical thinning compared with SAH cases (ATL: −0.08 ± 0.11 mm per year, SAH: −0.01 ± 0.02 mm per year,t = 2.99,P = 0.006). There were focal postoperative differences between the two treatment groups in the ipsilateral insula (P = 0.039, corrected). Annualized cortical thinning rates correlated with preoperative cortical thickness (r = 0.60,P < 0.001) and had weaker associations with age at surgery (r = −0.33,P = 0.051) and disease duration (r = −0.42,P = 0.058).SignificanceOur evidence suggests that selective procedures are associated with less cortical thinning and that earlier surgical intervention may reduce long‐term impacts on brain structure.
Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate
Authors: Koepp Matthias J. , Trinka Eugen , Mah Yee‐Haur , Bentes Carla , Knake Susanne , Gigli Gian Luigi , Serratosa José M. , Zelano Johan , Magalhães Luís M. , Pereira Ana , Moreira Joana , Soares‐da‐Silva Patrício 
Published: March 2023

AbstractThere is currently no evidence to support the use of antiseizure medications to prevent unprovoked seizures following stroke. Experimental animal models suggested a potential antiepileptogenic effect for eslicarbazepine acetate (ESL), and a Phase II, multicenter, randomized, double‐blind, placebo‐controlled study was designed to test this hypothesis and assess whether ESL treatment for 1 month can prevent unprovoked seizures following stroke. We outline the design and status of this antiepileptogenesis study, and discuss the challenges encountered in its execution to date. Patients at high risk of developing unprovoked seizures after acute intracerebral hemorrhage or acute ischemic stroke were randomized to receive ESL 800 mg/d or placebo, initiated within 120 hours after primary stroke occurrence. Treatment continued until Day 30, then tapered off. Patients could receive all necessary therapies for stroke treatment according to clinical practice guidelines and standard of care, and are being followed up for 18 months. The primary efficacy endpoint is the occurrence of a first unprovoked seizure within 6 months after randomization (“failure rate”). Secondary efficacy assessments include the occurrence of a first unprovoked seizure during 12 months after randomization and during the entire study; functional outcomes (Barthel Index original 10‐item version; National Institutes of Health Stroke Scale); post‐stroke depression (Patient Health Questionnaire‐9; PHQ‐9); and overall survival. Safety assessments include the evaluation of treatment‐emergent adverse events; laboratory parameters; vital signs; electrocardiogram; suicidal ideation and behavior (PHQ‐9 question 9). The protocol aimed to randomize approximately 200 patients (1:1), recruited from 21 sites in seven European countries and Israel. Despite the challenges encountered, particularly during the COVID‐19 pandemic, the study progressed and included a remarkable number of patients, with 129 screened and 125 randomized. Recruitment was stopped after 30 months, the first patient entered in May 2019, and the study is ongoing and following up on patients according to the Clinical Trial Protocol.
Optimum parameters of variant tuned mass damper using equal eigenvalue criterion
Authors: Thakur Vikas M. , Jaiswal Omprakash R. 
Published: March 2023

AbstractIn this study, optimum parameters of a variant tuned mass damper (V‐TMD) wherein, damper is connected to the ground are obtained using equal eigenvalue (EEV) criterion. In EEV, TMD parameters are obtained by equating eigenvalues of two modes. By equating eigenvalues, the modal damping ratios (i.e., negative real part of the eigenvalue) become equal and maximum in two modes. This optimum condition is achieved by finding the roots of a sixth order polynomial. One of the novel findings is regarding the existence of two sets of optimum parameters, out of which, one set matches exactly with one of the earlier study. Regions in which, single and two sets of optimum parameters exist, are clearly brought out. Performance of V‐TMD is demonstrated for harmonic as well as earthquake excitation. It is noted that displacement as well as acceleration of the main system reduces due to V‐TMD. Another significant finding is that the real part of eigenvalues of V‐TMD is larger than that of classical tuned mass damper (C‐TMD), which leads to faster decay of earthquake response and lower peak response. The optimum parameters obtained in this study, pertain to linear SDOF and V‐TMD.
Preliminary experimental data on surface runoff and soil loss in the Caatinga
Authors: Borges Neto Inocencio de Oliveira , Xavier Rafael Albuquerque , de Souza Bartolomeu Israel , Santos Leonardo José Cordeiro , Soares Diego Albuquerque , de Souza José João Lelis Leal 
Published: March 2023

AbstractSemi‐arid regions are naturally sensitive to soil erosion due to sparse vegetation cover and concentrated rainfall regime. Absence of conservative practices increases soil loss and reduces water retention. Despite the propagation of erosive process in the Brazilian semi‐arid region, few studies address the spatial and temporal distribution of surface erosive processes. Therefore, the present study presents preliminary results of a monitored soil loss and runoff experiment in the Brazilian semi‐arid region. Four plots were set up on the dominant soil groups, Luvisols and Regosols, traditional land uses, fallow system and cactus palm cultivation. Precipitation, surface runoff and soil loss were monitored for 22 months. The plots with the fallow system were more efficient in containing the hydro‐erosive dynamics than the plots with the cactus palm. The high difference in soil erosion between fallow system plots and cactus palm indicates that the human impact on soil loss is substantial. The significant correlation between precipitation and surface runoff allows the prediction of surface runoff. The weak correlation between precipitation and soil loss indicates that erosion is complex, with a strong influence on soil properties and use. The propagation of erosive processes in the Brazilian semi‐arid region induces loss of soil fertility, acceleration of the desertification process and impoverishment of rural communities. Specific conservative practices should be developed to reduce soil loss and mitigate anthropic disturbance in these areas. The surface runoff in Luvisol was up to 47% higher than those measured in Regosol. The plots with cactus palm showed a loss of organic carbon and nitrogen up to seven times greater than the plots in fallow system. Regosol is more sensitive to land‐use change compared with Luvisol.
CO2 capture performance of a CaO sorbent modified with fulvic acid for the calcium looping cycle
Authors: Jiang Dazhan , Wang Yaru , Li Zetong , Li Shuaipeng , Zhang Li , Chen Luhan , Sun Zhiguo 
Published: March 2023

AbstractCapturing CO2 from fossil fuel combustion is of importance for mitigation of climate warming. Among the CO2 capture technologies, the calcium‐based sorbent method is promising. However, the most prominent problem of this method at present is that the activity of the sorbent decreases as the number of cycle reactions increases. It seriously affects the industrial application of the calcium‐based sorbent method in carbon capture technology. Fulvic acid (FA) is a biologically active and soluble component of humic acid. Compared with other humic acids, it contains more oxygen and heterocyclic rings. Also, the rings are connected by bridge bonds. Therefore, the ability of FA to chelate cations and its adsorption capacity is stronger than the other humic acids. Therefore, in this work, we first proposed using FA to modify CaO to improve CO2 capture from flue gas. The effects of calcination temperature, carbonation temperature, reaction time and the amount of doped FA on the carbonation conversion rate (CCR) of CaO modified with FA (FA/CaO) were studied in the calcining/carbonizing room at atmospheric pressure. The experiment showed that the first CCR (X1) of FA/CaO reached 0.872 under the optimal conditions, which was 31% higher than X1 of original CaO. The 20th CCR (X20) was still as high as 0.47, which was three times than X20 of original CaO. In addition, the sorbent was analyzed and characterized by XRD, SEM, BET and LPSA. Due to the doped FA, the microstructure of CaO became fluffy and open, which improved the specific surface area and pore size of CaO. It indicated that the addition of FA was beneficial to the diffusion and absorption of CO2 and delayed the appearance of sintering, which significantly enhanced the CO2 capture performance of CaO. Using FA to modify CaO to capture CO2 provides an idea for efficient carbon capture, and has practical application potential. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Determinants of antimicrobial resistance occurrence in animal‐based food, perceived by livestock farmers: A qualitative phenomenological study
Authors: Toghroli Razie , Aghamolaei Teamur , Hassani Laleh , Sharifi Hamid , Jajarmi Maziar 
Published: March 2023

AbstractBackground and Purpose of the StudyThe determinants of antimicrobial resistance in human medicine have been copiously explored. On the other hand, the existing research in veterinary medicine and animal husbandry is in its infancy. The present qualitative study used the one‐health approach to explore farmers’ attitudes toward antimicrobial use and antimicrobial stewardship.MethodologyThe present qualitative study was phenomenological in type. It was conducted in 2022 in the two cities of Kerman and Bandar Abbas in Iran. The data were collected through in‐depth interviews by semistructured interviews with 17 livestock, poultry, and aquatic animal breeders selected through purposive sampling. The interviews lasted between 35 and 65 min in the Farsi language. The data were analyzed using conventional qualitative content analysis and Colaizzi's seven‐step analysis technique.ResultsThe open coding was done in MAXQDA 10 and the results of data analysis were classified into five main themes and 17 subthemes subcategories. The main categories include personal determinants, contextual determinants, legal and regulatory determinants, social determinants, and economic determinants.ConclusionConsidering the increasing use of antibiotics among livestock farmers and breeders of animals used as human food, different measures such as educational, regulatory, social, and even cultural interventions may be able to control and prevent antimicrobial resistance.
China special issue on gastrointestinal tumors—NTRK fusion in a large real‐world population and clinical utility of circulating tumor DNA genotyping to guide TRK inhibitor treatment
Authors: Qi Changsong , Zhou Ting , Bai Yuezong , Chen Hui , Yuan Jiajia , Zhao Feilong , Liu Chang , Ma Mingyang , Bei Ting , Chen Shiqing , Zhao Xiaochen , Chen Chunzhu , Shen Lin 
Published: March 2023

AbstractNeurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers and targets of TRK inhibitors in solid tumors. Little is known about NTRK fusion in Chinese patients with pan‐cancer. Our study investigated the prevalence and genomic features of NTRK1/2/3 gene fusions in 67 883 Chinese patients with pan‐cancer using next‐generation sequencing (NGS) data and circulating tumor DNA (ctDNA) NGS to guide TRK inhibitor treatment and resistance monitoring. The prevalence of NTRK fusion (tissue NGS) in the pan‐cancer population was 0.18%, with 46 unique NTRK‐fusion partner pairs, of which 33 were not previously reported. NTRK2 breakpoint occurred more frequently in intron 15 than intron 12. In colorectal cancers (CRCs), compared to NTRK‐negative tumors, NTRK‐positive tumors displayed higher tumor mutational burden (TMB) levels (54.6 vs 17.7 mut/Mb, P < .0001). In microsatellite instability‐high (MSI‐H) CRC, patients with NTRK fusion had a significantly lower TMB than NTRK‐negative cases (69.3 vs 79.9 mut/Mb, P = .012). The frequency of NTRK fusion in a ctDNA NGS cohort of 20 954 patients with cancer was similar to that of the tissue NGS cohort. In eight NTRK fusion ctDNA‐positive patients, larotrectinib induced objective response in 75% of patients and median progression‐free survival was 16.3 months. Blood samples collected from a patient with disease progression after larotrectinib treatment revealed NTRK3 G623R as the potential resistance mechanism. Our study revealed previously unreported NTRK fusion partners, associations of NTRK fusion with MSI and TMB, and the potential utility of ctDNA to screen candidates for TRK inhibitors and monitor drug resistance.
Input significance ranking of microalgae continuous culture models
Authors: Sangregorio‐Soto Viyils , Garzón‐Castro Claudia L , Mazzanti Gianfranco 
Published: March 2023

AbstractBackgroundMicroalgal cultures are evolving into a promising ecofriendly technology for a host of applications. To be sustainable, culture conditions need to be optimized and then controlled. One way to develop robust controllers for a cultivation system is by using mathematical growth models to simulate microalga‐based production. In this scenario, engineering design tasks begin by selecting the critical variables of these models.ResultsA new methodology for determining the significance ranking of a model's input factors under steady‐state operation (parameters (e.g. biological, geometrical) and/or process variables) was designed. The sensitivity of biomass response to its inputs was investigated in four different photobioreactor growth models within a nominal operational region. The methodology ranks models’ input factors based on the one‐at‐a‐time Morris method of elementary effects and variance‐based Sobol's method. Such information provided by the presented procedure is valuable as it reveals which input parameters explain most of the variance in model predictions.ConclusionThe methodology allowed the identification of controlled variables and biological parameters to be targeted for enhanced calibration. Furthermore, the presented methodology showed that in continuous reactors the dilution rate is a critical variable of the process. Therefore, it should be controlled. Additionally, most surprisingly, it is observed that controlling the light intensity within the optimum point of operation is not necessarily a crucial task. However, although its manipulation is still important, the accurate calibration of the parameters of the model may represent a greater influence on the biomass response. © 2023 Society of Chemical Industry (SCI).
Productive qualities of geese when crossing breeds and using hepatoprotective complex
Authors: Khaziev Danis , Gadiev Rinat , Farrakhov Albert , Kapylova Svetlana , Gilmanova Guzel 
Published: March 2023

AbstractThe study was on a one‐way cross between Wanxi male and Lindov female geese, and tested the effects of a hepatoprotective compound on growth and other traits in the parental and one‐way cross involving male and female progeny. The hybrids obtained from crossing had high viability and productivity; their level was also positively affected by giving a hepatoprotective complex. Female parents were the Lindov breed's geese, and male parents were 120 geese of the Chinese Wanxi breed. During the growing period, hybrid young birds were receiving a hepatoprotective complex in the amount of 1.0 mL per 1 L of water for 7 days. The research took into account geese' safety indices, live weight, and absolute and average daily gain. The interbreeding results prove that the resulting hybrids' safety index is 2.38%–4.54% higher than the parent forms' safety index. The hybrids' live weight increased by 8.4% due to a higher increase in live weight by 16.5%–22.1% allowing us to conclude the positive effect of crossing and using a hepatoprotective complex when breeding geese. The research made it possible to improve geese' productive qualities through hybridization and the use of a hepatoprotective complex. This information can contribute to the genetic improvement of body size in current breeding programs.
Barriers in applying to genetic counseling Master's degree programs: Perceptions of prospective applicants when compared with Canadian admissions committee members
Authors: Zahavich Laura , Babul‐Hirji Riyana 
Published: March 2023

AbstractThe goal of this study was to identify potential barriers in applying to a genetic counseling (GC) Master's degree program to inform strategies for increasing diversity and inclusiveness in the GC student recruitment process. Participants included prospective GC program applicants and admissions committee members from the four Canadian accredited programs. The study was conducted using a quantitative survey‐based approach. Twenty‐five prospective applicants who previously applied to a GC Master's degree program, 26 who had not applied, and 48 admissions committee members completed the survey. The small number of positions in GC programs was perceived by all groups as highly likely to impact an applicant's ability to gain acceptance to a program as was the limited number of GC training programs. Prospective applicants perceived additional barriers as significantly more likely to impact an individual's ability to apply to/attend a program when compared with admissions committee members including: cost of the application process, the applicant being a visible minority and the applicant having a physical disability. These findings highlight a number of perceived barriers related to applying to a GC Master's degree program. To our knowledge, this is the first study surveying prospective applicants and admissions committee members on barriers faced during the application process. The data from this study can also be used to inform the application process for other health professions.
Using ancillary data to model the terrestrial distribution of gopher frogs
Authors: Marshall Craig D. , Crawford Brian A. , Smith Lora L. , Enge Kevin M. , Elliott Matt , McGuire Savannah , Maerz John C. 
Published: March 2023

AbstractAn inherent challenge in managing rare or cryptic species is data deficiency. For this reason, ancillary data is a potentially valuable resource for generating key population estimates for priority species. We compiled ancillary commensal data collected between 1982 and 2020 during surveys of gopher tortoise (Gopherus polyphemus) burrows to estimate the terrestrial distribution of gopher frogs (Rana capito) from potential breeding wetlands. Gopher frogs were detected in gopher tortoise burrows 30‒3,879 m from identified wetlands. A global model of all records from all sites indicated that the probability of a gopher frog residing in a gopher tortoise burrow declined with increasing distance from a wetland. This pattern also held for 4 of 5 sites with a sufficient number of gopher frog detections to model independently. Based on the full data set, we estimated that 50%, 90%, and 99% of gopher frog observations occurred within 392 m, 1,019 m, and 2,752 m of the nearest wetland, respectively. Our results indicate a higher proportion of gopher frogs emigrate longer distances from wetlands than was previously reported using other methods, such as radio‐telemetry. This information can directly assist with management decisions, notably the spatial extent for application of habitat management surrounding breeding wetlands. More generally, this study illustrates the capacity of ancillary data to fill data deficiencies for a rare and cryptic species and highlights the importance of these data.