bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term lithium therapy and risk of chronic kidney disease, hyperparathyroidism and hypercalcemia: a cohort study
Authors: Boivin Elise , Le Daré Brendan , Bellay Romain , Vigneau Cécile , Mercerolle Marion , Bacle Astrid 
Published: January 2023

Abstract
Background
Lithium is well recognized as the first-line maintenance treatment for bipolar disorder (BD). However, besides therapeutic benefits attributed to lithium therapy, the associated side effects including endocrinological and renal disorders constitute important parameters in prescribing patterns and patient adherence. The objectives of this study is to (i) determine whether long-term lithium therapy is associated with a decrease in renal function, hyperparathyroidism and hypercalcemia and (ii) identify risk factors for lithium-induced chronic kidney disease (CKD).

Methods
We conducted a single-centered cohort study of adult patients (≥ 18 years) treated with lithium, who were enrolled at Rennes University Hospital in France between January 1, 2018 and June 1, 2020. Required data were collected from the patient’s medical records: demographics characteristics (age, sex, body mass index), biologic parameters (GFR, lithium blood level, PTH and calcium), medical comorbidities (hypertension and diabetes), lithium treatment duration and dosage, and length of hospitalization.

Results
A total of 248 patients were included (mean age: 60.2 ± 16.5 years). Duration of lithium treatment correlated with (i) deterioration of renal function estimated at − 2.9 mL/min/year (p < 0.0001) and (ii) the development of hyperparathyroidism (p < 0.01) and hypercalcemia (p < 0.01). We also noted that patients with lithium blood level > 0.8 mEq/mL had significantly lower GFR than patients with lithium blood level < 0.8 mEq/mL (61.8 mL/min versus 77.6 mL/min, respectively, p = 0.0134). Neither diabetes mellitus nor hypertension was associated with more rapid deterioration of renal function.

Conclusion
This study suggests that the duration of lithium treatment contribute to the deterioration of renal function, raising the question of reducing dosages in patients with a GFR < 60 mL/min. Overdoses has been identified as a risk factor for CKD, emphasizing the importance of regular re-evaluation of the lithium dose regimen. Also, long-term lithium therapy was associated with hyperparathyroidism and hypercalcemia. Particular vigilance is required on these points in order to limit the occurrence of endocrinological and renal lithium adverse effects.
Influence of habitat heterogeneity on avian diversity in the Rajparian Wildlife Sanctuary, Kashmir Himalaya
Authors: Bhat Aadil Hussain , Mir Altaf Hussain , Charoo Samina Amin 
Published: January 2023

Abstract
Background
The value of local and regional landscapes for avian conservation requires a thorough understanding of the diversity and structure of bird communities. Avifauna serves as an important biological indicator in monitoring the health of an ecosystem or environment. The present study was conducted to examine the relationship between avian diversity, richness, composition and habitat characteristics at the Rajparian Wildlife Sanctuary.

Results
Using geographic information systems and remote sensing techniques, we analyzed habitat heterogeneity based on land use and land cover classification. For sampling birds, extensive surveys were conducted in different land-use types from 2019 to 2021, following the line transect method. During the study period, 102 bird species were recorded from the five studied vegetation types of the study area, including one near threatened (Bearded Vulture) and one vulnerable (Kashmir Flycatcher) bird species. The highest numbers of avian species were recorded from the forest (71 species) (42.61 ± 16; mean ± SD) and the lowest from the rocky land-use type (12 species) (7.83 ± 1.95). The individual rarefaction and extrapolation curves showed higher species richness for forest and the lowest for rocky habitats. Numerous pairwise comparisons revealed significant differences in species richness among studied habitat types, except for riverine vs. grassland, scrub vs. grassland and rocky vs. riverine land uses. The partitioning of the spatio-temporal β-diversity patterns revealed a relatively large contribution of the turnover component to the observed overall dissimilarity compared to the nestedness component.

Conclusions
It can be concluded that avian communities in the Rajparian Wildlife Sanctuary are influenced by habitat heterogeneity, topography, and the availability of water. The results of the present study indicate that the Rajparian Wildlife Sanctuary provides an important habitat for the conservation of birds, as it harbors a rich avian diversity. The study is the first scientific survey of the avian habitat associations in the protected area and will serve as a baseline for future avian research, as well as for management implications in the region.
Irreversible Alterations of Susceptibility in Cushing's Disease: A Longitudinal QSM Study
Authors: Jiang Hong , Li Zhenghao , Sun Yuhao , Ren Jie , Yan Fuhua , Sun Qingfang , Wei Hongjiang , Bian Liuguan 
Published: February 2023

Abstract

Objectives
Chronic exposure to hypercortisolism is associated with accelerated aging and neurodegenerative diseases, while Cushing's disease (CD) is the most common form of endogenous hypercortisolism exposure. This study aimed to assess longitudinal susceptibility changes in CD using quantitative susceptibility mapping (QSM) before and after resolution of hypercortisolism.

Methods
In this study, 24 CD patients and 24 healthy controls underwent magnetic resonance imaging (MRI) with QSM. All CD patients underwent MRI scans before and after the curative operation.

Results
After resolution of hypercortisolism, irreversibly altered susceptibility values were found in the anterior cingulate cortex, frontal lobe, caudate, and red nucleus. These alterations were significantly correlated with the changes in gray matter/white matter volumes and clinical features. Additionally, decreased susceptibility was found in several regions in CD patients.

Conclusion
Chronic exposure to hypercortisolism may be related to susceptibility alterations and significantly correlated with altered brain volumes and clinical features. in CD patients. The decrease of susceptibility might suggest the involvement of the calcium deregulation in these alterations.
Using 68Ga-DOTATATE PET for Postoperative Radiosurgery and Radiotherapy Planning in Patients With Meningioma: A Case Series
Authors: Hintz Eric B. , Park David J. , Ma Daniel , Viswanatha Sirisha Devi , Rini Josephine N. , Schulder Michael , Goenka Anuj 
Published: February 2023

BACKGROUND:
For patients with either an incompletely resected meningioma or recurrence after surgery, stereotactic radiosurgery is frequently used. MRI is typically used for stereotactic radiosurgery targeting, but differentiating tumor growth from postoperative change can be challenging. 68Ga-DOTATATE, a positron emission tomography (PET) radiotracer targeting the somatostatin receptor type 2, has been shown to be a reliable meningioma biomarker.

OBJECTIVE:
To evaluate the impact of 68Ga-DOTATATE on treatment planning in patients who had previously undergone meningioma resection.

METHODS:
We present a consecutive case series of 12 patients with pathology-proven meningioma who received a 68Ga-DOTATATE PET between April 2019 and April 2021. Treatment planning was performed first using MRI. DOTATATE-PET images were then used to assess accurate tumor identification.

RESULTS:
Ten patients had WHO Grade 2 meningioma, and 2 patients had Grade 1 tumor. Eight patients had recurrent meningiomas, and 4 patients had newly diagnosed disease. Overall, 68Ga-DOTATATE PET scans altered previously formulated treatment plans in 5 of 12 patients. In addition, 9 of 12 patients had disease foci not appreciated on MRI.

CONCLUSION:
In this series, incorporating 68Ga-DOTATATE PET imaging had clinical utility for most patients in whom it was used. It proved particularly adept in demonstrating intraosseous meningiomas, differentiating recurrence from postoperative changes, and identifying subcentimeter disease foci. It is an imaging modality that our center will continue to use as a means of improving postoperative treatment plans after the surgical resection of meningiomas.
Diastereomeric Effect on Bulk Photovoltaic Property and Polarized Electroluminescence in Ferroelectric Liquid Crystals Containing an Extended π-Conjugated Unit
Authors: Matoba Yuji , Uemura Shinobu , Funahashi Masahiro 
Published: February 2023

Abstract
We synthesized two diastereomers comprising the same π-conjugated unit. One diastereomer exhibited a smectic crystal phase in which the chromophores tilted 45 degrees from the layer normal and macroscopic polarization was induced by a DC bias application in a cooling process from the high temperature phase to the smectic crystal phase. The other diastereomer exhibited a smectic crystal phase in which the chromophores were parallel to the layer normal and macroscopic polarization was not induced. The bulk photovoltaic effect and polarization-induced electroluminescence were observed only in the polarized smectic crystal phase in which the chromophores tilted from the layer normal. In the bulk photovoltaic effect in the tilted smectic crystal phase doped with fullerene derivative, the open circuit voltage and short circuit current were 1.03 V and 100 µAcm−2 for white light illumination (20 mWcm−2), respectively. In the polarization-induced electroluminescence in the tilted smectic crystal phase, linearly polarized emission with the dichroic ratio exceeding 10 was obtained and the axis of the linearly polarized emission could be rotated 90 degrees by an inversion of a DC bias of poling treatment.
Shellable tilings on relative simplicial complexes and their h-vectors
Authors: Welschinger Jean-Yves 
Published: February 2023

Abstract
An h-tiling on a finite simplicial complex is a partition of its geometric realization by maximal simplices deprived of several codimension one faces together with possibly their remaining face of highest codimension. In this last case, the tiles are said to be critical. An h-tiling thus induces a partitioning of its face poset by closed or semi-open intervals. We prove the existence of h-tilings on every finite simplicial complex after finitely many stellar subdivisions at maximal simplices. These tilings are moreover shellable. We also prove that the number of tiles of each type used by a tiling, encoded by its h-vector, is determined by the number of critical tiles of each index it uses, encoded by its critical vector. In the case of closed triangulated manifolds, these vectors satisfy some palindromic property. We finally study the behavior of tilings under any stellar subdivision.
Novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant in a child patient with Joubert syndrome
Authors: Wang Huiping , Nie Wensha , Wang Chunxia , Wang Zuohua , Zheng Yuxia 
Published: February 2023

Abstract
Joubert syndrome (JBTS) is a class of heterogeneous ciliopathy genetically associated with CPLANE1 mutations. The characteristics of clinical phenotypes and CPLANE1 variants were analyzed in a 2-month-old patient. A 2-month-old patient with JBTS was diagnosed after clinical evaluation including family history, physical examination, cerebral MRI, ultrasonography imaging, VEGG, ocular fundus examination, and comprehensive blood and urine testing. Whole exome sequencing (WES) was performed to detect CPLANE1 variants, and Sanger sequencing was used to confirm the variants. This JBTS patient presented with oculomotor apraxia, dysregulation of breathing pattern, and ataxia. MRI revealed poor continuity of cerebelli, batwing appearance, and molar tooth sign. This patient was noted with abnormal hematology, dysregulation of hepatic function, thyroid function, immunity, and renal function, and encephalopathy. CPLANE1 (c.8948dupT (p.P2984Tfs*7) and c.247G > T (p.G83X)) variants were noticed in the patient as a pathogenic variant and caused autosomal recessive inheritance. The JBTS patient with mutations in CPLANE1 (c.8948dupT (p.P2984Tfs*7) and c.247G > T (p.G83X)) developed JBTS phenotypes. The novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant will assist clinicians and geneticists in reaching a precise diagnosis for JBTS.
A new and improved method of library preparation for non-invasive prenatal testing: plasma to library express technology
Authors: Ren Meihong , Sun Guangxin , Kong Xiangsha , Zhang Lin , Ji Ying , Rao Huiying , Du Liuyezi , Zhang Xiaohong , Wu Qixi 
Published: January 2023

Abstract

Objectives
This study aims to develop a novel library preparation method, plasma to library express technology (PLET), to construct next-generation sequencing (NGS) libraries directly from plasma without cell-free DNA (cfDNA) isolation.

Methods
Peripheral blood samples (600) were obtained from a retrospective cohort of 300 pregnant women prior to invasive diagnostic testing. The samples were subsequently distributed between library preparation methodologies, with 300 samples prepared by PLET and 300 by conventional methods for non-invasive prenatal testing (NIPT) to screen for common trisomies using low-pass whole genome next generation sequencing.

Results
NIPT conducted on PLET libraries demonstrated comparable metrics to libraries prepared using conventional methods, including 100% sensitivity and specificity.

Conclusions
Our study demonstrates the potential utility of PLET in the clinical setting and highlights its significant advantages, including dramatically reduced process complexity and markedly decreased turnaround time.
On the asymptotics of the shifted sums of Hecke eigenvalue squares
Authors: Kim Jiseong 
Published: January 2023

Abstract
The purpose of this paper is to obtain asymptotics of shifted sums of Hecke eigenvalue squares on average. We show that for

X

2
3

+
ϵ

<
H
<

X

1
-
ϵ

{X^{\frac{2}{3}+\epsilon}<H<X^{1-\epsilon}}

there are constants

B
h

{B_{h}}

such that

∑

X
≤
n
≤

2
⁢
X

λ
f

⁢

(
n
)

2

⁢

λ
f

⁢

(

n
+
h

)

2

-

B
h

⁢
X

=

O

f
,
A
,
ϵ

⁢

(

X
⁢

(

log
⁡
X

)

-
A

)

\sum_{X\leq n\leq 2X}\lambda_{f}(n)^{2}\lambda_{f}(n+h)^{2}-B_{h}X=O_{f,A,%
\epsilon}(X(\log X)^{-A})

for all but

O

f
,
A
,
ϵ

⁢

(

H
⁢

(

log
⁡
X

)

-

3
⁢
A

)

{O_{f,A,\epsilon}(H(\log X)^{-3A})}

integers

h
∈

[
1
,
H
]

{h\in[1,H]}

where

{

λ
f

⁢

(
n
)

}

n
≥
1

{\{\lambda_{f}(n)\}_{n\geq 1}}

are normalized Hecke eigenvalues of a fixed holomorphic cusp form f.
Our method is based on the Hardy–Littlewood circle method. We divide the minor arcs into two parts

m
1

{m_{1}}

and

m
2

{m_{2}}

. In order to treat

m
2

{m_{2}}

, we use the Hecke relations, a bound of Miller to apply some arguments from a paper of Matomäki, Radziwiłł and Tao. In order to treat

m
1

{m_{1}}

, we apply Parseval’s identity and Gallagher’s lemma.
Almost Dedekind domains without radical factorization
Authors: Spirito Dario 
Published: January 2023

Abstract
We study almost Dedekind domains with respect to the failure of ideals to have radical factorization, that is, we study how to measure how far an almost Dedekind domain is from being an SP-domain. To do so, we consider the maximal space

ℳ
=

Max
⁡

(
R
)

{\mathcal{M}=\operatorname{Max}(R)}

of an almost Dedekind domain R, interpreting its (fractional) ideals as maps from

ℳ

{\mathcal{M}}

to

ℤ

{\mathbb{Z}}

, and looking at the continuity of these maps when

ℳ

{\mathcal{M}}

is endowed with the inverse topology and

ℤ

{\mathbb{Z}}

with the discrete topology. We generalize the concept of critical ideals by introducing a well-ordered chain of closed subsets of

ℳ

{\mathcal{M}}

(of which the set of critical ideals is the first step) and use it to define the class of SP-scattered domains, which includes the almost Dedekind domains such that

ℳ

{\mathcal{M}}

is scattered and, in particular, the almost Dedekind domains such that

ℳ

{\mathcal{M}}

is countable. We show that for this class of rings the group

Inv
⁢

(
R
)

{\mathrm{Inv}(R)}

is free by expressing it as a direct sum of groups of continuous maps, and that, for every length function

ℓ

{\ell}

on R and every ideal I of R, the length of

R
/
I

{R/I}

is equal to the length of

R
/

rad
⁡

(
I
)

{R/{\operatorname{rad}(I)}}

.
GKM actions on cohomogeneity one manifolds
Authors: Goertsches Oliver , Loiudice Eugenia , Russo Giovanni 
Published: January 2023

Abstract
We consider compact manifolds M with a cohomogeneity one action of a compact Lie group G such that the orbit
space

M
/
G

{M/G}

is a closed interval.
For T a maximal torus of G, we find necessary and sufficient conditions on the group diagram of M such that
the T-action on M is of GKM type, and describe its GKM graph.
The general results are illustrated on explicit examples.
Gruenberg–Kegel graphs: Cut groups, rational groups and the prime graph question
Authors: Bächle Andreas , Kiefer Ann , Maheshwary Sugandha , del Río Ángel 
Published: January 2023

Abstract
The Gruenberg–Kegel graph of a group is the undirected graph whose vertices are those primes which occur as the order of an element of the group, and distinct vertices p, q are joined by an edge whenever the group has an element of order pq.
It reflects interesting properties of the group.
A group is said to be cut if the central units of its integral group ring are trivial.
This is a rich family of groups, which contains the well-studied class of rational groups, and has received attention recently. In the first part of this paper, we give a complete classification of the Gruenberg–Kegel graphs of finite solvable cut groups which have at most three elements in their prime spectrum. For the remaining cases of finite solvable cut groups, we strongly restrict the list of the possible Gruenberg–Kegel graphs and realize most of them by finite solvable cut groups. Likewise, we give a list of the possible Gruenberg–Kegel graphs of finite solvable rational groups and realize as such all but one of them. As an application, we completely classify the Gruenberg–Kegel graphs of metacyclic, metabelian, supersolvable, metanilpotent and 2-Frobenius groups for the classes of cut groups and rational groups, respectively. The prime graph question asks whether the Gruenberg–Kegel graph of a group coincides with that of the group of normalized units of its integral group ring. The recent appearance of a counter-example for the first Zassenhaus conjecture on the torsion units of integral group rings has highlighted the relevance of this question. We answer the prime graph question for integral group rings for finite rational groups and most finite cut groups
Sobolev regularity for nonlinear Poisson equations with Neumann boundary conditions on Riemannian manifolds
Authors: Goffi Alessandro , Pediconi Francesco 
Published: January 2023

Abstract
In this paper, we study the Sobolev regularity of solutions to nonlinear second order elliptic equations with super-linear first-order terms on Riemannian manifolds, complemented with Neumann boundary conditions, when the source term of the equation belongs to a Lebesgue space, under various integrability regimes. Our method is based on an integral refinement of the Bochner identity, and leads to “semilinear Calderón–Zygmund” type results.
Applications to the problem of smoothness of solutions to Mean Field Games systems
with Neumann boundary conditions posed on convex domains of the Euclidean space will also be discussed.
Free polynilpotent groups and the Magnus property
Authors: Klopsch Benjamin , Mendonça Luis , Petschick Jan Moritz 
Published: January 2023

Abstract
Motivated by a classic result for free groups, one says that a group
G has the Magnus property if the following holds: Whenever two
elements generate the same normal subgroup of G, they are
conjugate or inverse-conjugate in G.
It is a natural problem to find out which relatively free groups
display the Magnus property. We prove that a free polynilpotent
group of any given class row has the Magnus property if and only if
it is nilpotent of class at most 2. For this purpose we explore
the Magnus property more generally in soluble groups, and we produce
new techniques, both for establishing and for disproving the
property. We also prove that a free center-by-(polynilpotent of
given class row) group has the Magnus property if and only if it is
nilpotent of class at most 2. On the way, we display 2-generated nilpotent groups (with
non-trivial torsion) of any prescribed nilpotency class with the
Magnus property. Similar examples of finitely generated,
torsion-free nilpotent groups are hard to come by, but we construct
a 4-generated, torsion-free, class-3 nilpotent group of Hirsch
length 9 with the Magnus property. Furthermore, using a weak
variant of the Magnus property and an ultraproduct construction, we
establish the existence of metabelian, torsion-free, nilpotent
groups of any prescribed nilpotency class with the Magnus property.
Optimization method for a multi-parameters identification problem in degenerate parabolic equations
Authors: Yang Liu , Deng Zui-Cha 
Published: January 2023

Abstract
In this paper, we study the well-posedness of the solution of an
optimal control problem related to a multi-parameters identification
problem in degenerate parabolic equations. Problems of this type
have important applications in several fields of applied science.
Unlike other inverse coefficient problems for classical parabolic
equations, the mathematical model discussed in the paper is
degenerate on both lateral boundaries of the domain. Moreover, the
status of the two unknown coefficients are different, namely that
the reconstruction of the source term is mildly ill-posed, while the
inverse initial value problem is severely ill-posed. On the basis of
optimal control framework, the problem is transformed into an
optimization problem. The existence of the minimizer is proved and
the necessary conditions which must be satisfied by the minimizer
are also established. Due to the difference between ill-posedness
degrees of the two unknown coefficients, the extensively used
conjugate theory for parabolic equations cannot be directly applied
for our problem. By carefully analyzing the necessary conditions and
the direct problem, the uniqueness, stability and convergence of the
minimizer are obtained. The results obtained in the paper are
interesting and useful, and can be extended to more general parabolic equations with degenerate coefficients.
On a flexible class of asymmetric mixture normal distribution and its applications
Authors: Satheesh Kumar C. , Anila G. V. 
Published: January 2023

Abstract
Here we consider a more flexible class of asymmetric mixture normal distribution and investigate some of its important statistical properties. We define its location-scale extension and discuss the method of maximum likelihood for estimating its parameters. Two real life data sets are considered for illustrating the usefulness of the model. Further, a simulation study is carried out for examining the efficiency of maximum likelihood estimators of the parameters of the distribution.
On the stochastic flow generated by the one default model in one-dimensional case
Authors: Khatir Yamina , Benziadi Fatima , Kandouci Abdeldjebbar 
Published: January 2023

Abstract
In this paper, we will study an important property on the regularity of the trajectories of the stochastic flow generated by a famous model in finance. More precisely, we prove the differentiability with respect to initial data of the solution of the stochastic differential equation associated with this model based on Gronwall’s lemma, Itô’s isometry and Burkholder–Davis–Gundy’s and Hölder’s inequalities. This is the main motivation of our research.