bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of food choice values and food literacy with overall diet quality: a nationwide cross-sectional study in Japanese adults
Authors: Murakami Kentaro , Shinozaki Nana , Livingstone M. Barbara E. , Yuan Xiaoyi , Tajima Ryoko , Matsumoto Mai , Masayasu Shizuko , Sasaki Satoshi 
Published: April 2023

AbstractTo date, a limited number of studies have examined aspects of food choice values and food literacy in relation to some aspects of dietary behaviours. The aim of this cross-sectional study was to comprehensively examine the associations of food choice values and food literacy with diet quality. In total, 2231 Japanese adults aged 19–80 years completed questionnaires asking about food choice values (accessibility, convenience, health/weight control, tradition, sensory appeal, organic, comfort and safety) and food literacy characterised by nutrition knowledge, cooking skills, food skills and eating behaviours (hunger, food responsiveness, emotional overeating, enjoyment of food, satiety responsiveness, emotional undereating, food fussiness and slowness in eating). As a measure of diet quality, the Healthy Eating Index-2015 (HEI-2015) was calculated using a brief-type diet history questionnaire (BDHQ) or a food combination questionnaire (FCQ). In males, after adjustment for potential confounding factors (including age, BMI and the ratio of reported energy intake to estimated energy requirement), the HEI-2015 derived from BDHQ and that derived from FCQ were associated significantly (P ≤ 0·02) and positively with the food choice values of organic and inversely with food fussiness. In females, the HEI-2015 showed positive associations with the food choice values of health/weight control, nutrition knowledge and cooking skills and an inverse association with food fussiness, irrespective of the dietary assessment questionnaire (P ≤ 0·03). In conclusion, this study suggests that several aspects of food choice values and food literacy were associated with diet quality, and the aspects related differed between males and females.
What do windsurfers and kitesurfers in Germany know about surfer's ear and how is it influenced by protective measures?
Authors: Wegener F , Wegner M , Weiss N M 
Published: April 2023

AbstractObjectiveThis study investigated the frequency of ear canal protection use and looked at its influence on external auditory exostosis severity and knowledge about external auditory exostosis among windsurfers and kitesurfers on the German coast.MethodThis retrospective cross-sectional study interviewed 130 windsurfers and kitesurfers along the German coast on knowledge of external auditory exostosis, exposure time, use of neoprene hoods and earplugs, and otological complaints. Participants underwent bilateral video-otoscopic examination.ResultsKnowledge of external auditory exostosis was ‘good’ or ‘excellent’ in 78 of 130 (60 per cent) individuals and ‘poor’ or non-existent in 52 of 130 (40 per cent) individuals. Knowledge was positively correlated with hours of exposure, otological complaints and frequency of ear canal protection use. A significant negative influence of neoprene hood use on external auditory exostosis severity was shown.ConclusionThe positive effect of external auditory exostosis knowledge on the frequency of ear canal protection and the reduction of external auditory exostosis risk implies a need for health education on this topic.
The second-order problem of other minds
Authors: Friedman Ori , Tasimi Arber 
Published: April 2023

Abstract
The target article proposes that people perceive social robots as depictions rather than as genuine social agents. We suggest that people might instead view social robots as social agents, albeit agents with more restricted capacities and moral rights than humans. We discuss why social robots, unlike other kinds of depictions, present a special challenge for testing the depiction hypothesis.
Social robots as social learning partners: Exploring children's early understanding and learning from social robots
Authors: Haber Amanda , Corriveau Kathleen H. 
Published: April 2023

Abstract
Clark and Fischer propose that people interpret social robots not as social agents, but as interactive depictions. Drawing on research focusing on how children selectively learn from social others, we argue that children do not view social robots as interactive toys but instead treat them as social learning partners and critical sources of information.
A more ecological perspective on human–robot interactions
Authors: Ravikumar Varun , Bowen Jonathan , Anderson Michael L. 
Published: April 2023

Abstract
Drawing from two strands of ecological psychology, we suggest that even if social robots are interactive depictions, people need not mentally represent them as such. Rather, people can engage with the opportunities for action or affordances that social robots offer to them. These affordances are constrained by the larger sociocultural settings within which human–robot interactions occur.
Anthropomorphism, not depiction, explains interaction with social robots
Authors: Petersen Dawson , Almor Amit 
Published: April 2023

Abstract
We question the role given to depiction in Clark and Fischer's account of interaction with social robots. Specifically, we argue that positing a unique cognitive process for handling depiction is evolutionarily implausible and empirically redundant because the phenomena it is intended to explain are not limited to depictive contexts and are better explained by reference to more general cognitive processes.
Dipolarization Fronts in the Jovian Magnetotail: Statistical Survey of Ion Intensity Variations Using Juno Observations
Authors: Blöcker A. , Kronberg E. A. , Grigorenko E. E. , Roussos E. , Clark G. 
Published: April 2023

AbstractEnergetic particle acceleration and energization in planetary magnetotails are often associated with dipolarization fronts characterized by a rapid increase of the meridional component of the magnetic field. Despite many studies of dipolarization events in Earth's magnetotail, Jupiter’s magnetotail provides an almost ideal environment to study high‐energetic ion acceleration by dipolarization fronts because of its large spatial scales and plasma composition of heavy and light ions. In this study, we focus on the response of different high‐energetic ion intensities (H, He, S, and O) to prominent magnetic dipolarization fronts inside the Jovian magnetotail. We investigate if ion energization and acceleration are present in the observations around the identified dipolarization fronts. Therefore, we present a statistical study of 87 dipolarization front signatures, which are identified in the magnetometer data of the Juno spacecraft from July 2016 to July 2021. For the ion intensity analysis, we use the energetic particle observations from the Jupiter Energetic Particle Detector Instrument. Our statistical study reveals that less than half of the identified events are accompanied by an increase of the ion intensities, while most of the other events show no significant change in the ion intensity dynamics. In about 40% of the events located in the dawn sector a significant decrease of the energy spectral index is detected indicating ion acceleration by the dipolarization fronts.
Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau
Authors: Van Egroo Maxime , Riphagen Joost M. , Ashton Nicholas J. , Janelidze Shorena , Sperling Reisa A. , Johnson Keith A. , Yang Hyun-Sik , Bennett David A. , Blennow Kaj , Hansson Oskar , Zetterberg Henrik , Jacobs Heidi I. L. 
Published: April 2023

AbstractAutopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more vulnerable in the earlier stages of the disease. Taking advantage of recent developments in ultra-high field (7 T) imaging, we investigated whether imaging measures of the LC also reveal a specific anatomic correlation with tau using novel plasma biomarkers of different species of hyperphosphorylated tau, how early in adulthood these associations can be detected and if are associated with worse cognitive performance. To validate the anatomic correlations, we tested if a rostro-caudal gradient in tau pathology is also detected at autopsy in data from the Rush Memory and Aging Project (MAP). We found that higher plasma measures of phosphorylated tau, in particular ptau231, correlated negatively with dorso-rostral LC integrity, whereas correlations for neurodegenerative plasma markers (neurofilament light, total tau) were scattered throughout the LC including middle to caudal sections. In contrast, the plasma Aβ42/40 ratio, associated with brain amyloidosis, did not correlate with LC integrity. These findings were specific to the rostral LC and not observed when using the entire LC or the hippocampus. Furthermore, in the MAP data, we observed higher rostral than caudal tangle density in the LC, independent of the disease stage. The in vivo LC-phosphorylated tau correlations became significant from midlife, with the earliest effect for ptau231, starting at about age 55. Finally, interactions between lower rostral LC integrity and higher ptau231 concentrations predicted lower cognitive performance. Together, these findings demonstrate a specific rostral vulnerability to early phosphorylated tau species that can be detected with dedicated magnetic resonance imaging measures, highlighting the promise of LC imaging as an early marker of AD-related processes.
Hypoxia switches TET1 from being tumor-suppressive to oncogenic
Authors: Yang Qi , Dang Hui , Liu Jiaxin , Wang Xingye , Wang Jingyuan , Lan Xinhui , Ji Meiju , Xing Mingzhao , Hou Peng 
Published: April 2023

AbstractThe classical oxidizing enzymatic activity of Ten Eleven Translocation 1 (TET1) and its tumor suppressor role are well known. Here, we find that high TET1 expression is associated with poor patient survival in solid cancers often having hypoxia, which is inconsistent with its tumor suppressor role. Through a series of in vitro and in vivo studies, using thyroid cancer as a model, we demonstrate that TET1 plays a tumor suppressor function in normoxia and, surprisingly, an oncogenic function in hypoxia. Mechanistically, TET1 mediates HIF1α-p300 interaction by acting as a co-activator of HIF1α to promote CK2B transcription under hypoxia, which is independent of its enzymatic activity; CK2 activates the AKT/GSK3β signaling pathway to promote oncogenesis. Activated AKT/GSK3β signaling in turn maintains HIF1α at elevated levels by preventing its K48-linked ubiquitination and degradation, creating a feedback loop to enhance the oncogenicity of TET1 in hypoxia. Thus, this study uncovers a novel oncogenic mechanism in which TET1 promotes oncogenesis and cancer progression through a non-enzymatic interaction between TET1 and HIF1α in hypoxia, providing novel therapeutic targeting implications for cancer.
Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer
Authors: Cameron Sarina , Deblois Genevieve , Hawley James R. , Qamra Aditi , Zhou Stanley , Tonekaboni Seyed Ali Madani , Murison Alexander , Van Vliet Romy , Liu Juan , Locasale Jason W. , Lupien Mathieu 
Published: April 2023

AbstractPredicting and treating recurrence in intermediate-risk prostate cancer patients remains a challenge despite having identified genomic instability [1] and hypoxia [2, 3] as risk factors. This underlies challenges in assigning the functional impact of these risk factors to mechanisms promoting prostate cancer progression. Here we show chronic hypoxia (CH), as observed in prostate tumours [4], leads to the adoption of an androgen-independent state in prostate cancer cells. Specifically, CH results in prostate cancer cells adopting transcriptional and metabolic alterations typical of castration-resistant prostate cancer cells. These changes include the increased expression of transmembrane transporters for the methionine cycle and related pathways leading to increased abundance of metabolites and expression of enzymes related to glycolysis. Targeting of the Glucose Transporter 1 (GLUT1) identified a dependency on glycolysis in androgen-independent cells. Overall, we identified a therapeutically targetable weakness in chronic hypoxia and androgen-independent prostate cancer. These findings may offer additional strategies for treatment development against hypoxic prostate cancer.
Net greenhouse gas balance of fibre wood plantation on peat in Indonesia
Authors: Deshmukh Chandra S. , Susanto Ari P. , Nardi Nardi , Nurholis Nurholis , Kurnianto Sofyan , Suardiwerianto Yogi , Hendrizal M. , Rhinaldy Ade , Mahfiz Reyzaldi E. , Desai Ankur R. , Page Susan E. , Cobb Alexander R. , Hirano Takashi , Guérin Frédéric , Serça Dominique , Prairie Yves T. , Agus Fahmuddin , Astiani Dwi , Sabiham Supiandi , Evans Chris D. 
Published: April 2023

AbstractTropical peatlands cycle and store large amounts of carbon in their soil and biomass1–5. Climate and land-use change alters greenhouse gas (GHG) fluxes of tropical peatlands, but the magnitude of these changes remains highly uncertain6–19. Here we measure net ecosystem exchanges of carbon dioxide, methane and soil nitrous oxide fluxes between October 2016 and May 2022 from Acacia crassicarpa plantation, degraded forest and intact forest within the same peat landscape, representing land-cover-change trajectories in Sumatra, Indonesia. This allows us to present a full plantation rotation GHG flux balance in a fibre wood plantation on peatland. We find that the Acacia plantation has lower GHG emissions than the degraded site with a similar average groundwater level (GWL), despite more intensive land use. The GHG emissions from the Acacia plantation over a full plantation rotation (35.2 ± 4.7 tCO2-eq ha−1 year−1, average ± standard deviation) were around two times higher than those from the intact forest (20.3 ± 3.7 tCO2-eq ha−1 year−1), but only half of the current Intergovernmental Panel on Climate Change (IPCC) Tier 1 emission factor (EF)20 for this land use. Our results can help to reduce the uncertainty in GHG emissions estimates, provide an estimate of the impact of land-use change on tropical peat and develop science-based peatland management practices as nature-based climate solutions.
Blinded, randomized trial of sonographer versus AI cardiac function assessment
Authors: He Bryan , Kwan Alan C. , Cho Jae Hyung , Yuan Neal , Pollick Charles , Shiota Takahiro , Ebinger Joseph , Bello Natalie A. , Wei Janet , Josan Kiranbir , Duffy Grant , Jujjavarapu Melvin , Siegel Robert , Cheng Susan , Zou James Y. , Ouyang David 
Published: April 2023

AbstractArtificial intelligence (AI) has been developed for echocardiography1–3, although it has not yet been tested with blinding and randomization. Here we designed a blinded, randomized non-inferiority clinical trial (ClinicalTrials.gov ID: NCT05140642; no outside funding) of AI versus sonographer initial assessment of left ventricular ejection fraction (LVEF) to evaluate the impact of AI in the interpretation workflow. The primary end point was the change in the LVEF between initial AI or sonographer assessment and final cardiologist assessment, evaluated by the proportion of studies with substantial change (more than 5% change). From 3,769 echocardiographic studies screened, 274 studies were excluded owing to poor image quality. The proportion of studies substantially changed was 16.8% in the AI group and 27.2% in the sonographer group (difference of −10.4%, 95% confidence interval: −13.2% to −7.7%, P < 0.001 for non-inferiority, P < 0.001 for superiority). The mean absolute difference between final cardiologist assessment and independent previous cardiologist assessment was 6.29% in the AI group and 7.23% in the sonographer group (difference of −0.96%, 95% confidence interval: −1.34% to −0.54%, P < 0.001 for superiority). The AI-guided workflow saved time for both sonographers and cardiologists, and cardiologists were not able to distinguish between the initial assessments by AI versus the sonographer (blinding index of 0.088). For patients undergoing echocardiographic quantification of cardiac function, initial assessment of LVEF by AI was non-inferior to assessment by sonographers.
Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula)
Authors: Gaigher Arnaud , Rota Alessia , Neves Fabiana , Muñoz-Mérida Antonio , Blasco-Aróstegui Javier , Almeida Tereza , Veríssimo Ana 
Published: April 2023

AbstractThe major histocompatibility complex (MHC) is a multigene family responsible for pathogen detection, and initiation of adaptive immune responses. Duplication, natural selection, recombination, and their resulting high functional genetic diversity spread across several duplicated loci are the main hallmarks of the MHC. Although these features were described in several jawed vertebrate lineages, a detailed MHC IIβ characterization at the population level is still lacking for chondrichthyans (chimaeras, rays and sharks), i.e. the most basal lineage to possess an MHC-based adaptive immune system. We used the small-spotted catshark (Scyliorhinus canicula, Carcharhiniformes) as a case-study species to characterize MHC IIβ diversity using complementary molecular tools, including publicly available genome and transcriptome datasets, and a newly developed high-throughput Illumina sequencing protocol. We identified three MHC IIβ loci within the same genomic region, all of which are expressed in different tissues. Genetic screening of the exon 2 in 41 individuals of S. canicula from a single population revealed high levels of sequence diversity, evidence for positive selection, and footprints of recombination. Moreover, the results also suggest the presence of copy number variation in MHC IIβ genes. Thus, the small-spotted catshark exhibits characteristics of functional MHC IIβ genes typically observed in other jawed vertebrates.
Hydroxychloroquine is neutral on incidental cataracts in patients with rheumatoid arthritis
Authors: Zhang Zhibo , Ma Xin , Wang Yu-Hsun , Shi Xiaofei , Wei James Cheng-Chung 
Published: April 2023

AbstractTo study whether hydroxychloroquine (HCQ) therapy increases the risks of cataracts in patients with rheumatoid arthritis (RA). In this retrospective cohort study, 2821 treatment-naive RA patients, collected from the Longitudinal Health Insurance Database, were enrolled from 2000 to 2012 and followed up monthly until secondary cataracts were detected but no later than Dec 31, 2013. All participants were split into two groups according to the usage of HCQ in one year: the HCQ group (465 patients), with a usage duration higher than 90 days, and the non-HCQ group (465 patients), with a usage duration less than 30 days. The HCQ and non-HCQ groups were age-, sex-, complication- and drug combination-matched. There was no significant difference in survival rate between the two groups (p > 0.05). A multivariate logistic regression model was applied. Of all participants, 173 were diagnosed with secondary cataracts in both the HCQ and non-HCQ groups, with 28.8/1000 and 36.5/1000 person-years, respectively. After adjustments for other predictors, patients in the HCQ group had no increased (or decreased/equal) hazard of secondary cataract (hazard ratio (HR): 1.17; confidence interval (CI): 0.86–1.59; p > 0.05). HR analysis of HCQ usage duration, age, sex and corticosteroids showed that the CI of the adjusted HR was not statistically significant. This study showed that HCQ usage was not associated with the risk of cataracts in RA patients.
Exploring body weight-influencing gut microbiota by elucidating the association with diet and host gene expression
Authors: Nemoto Shino , Kubota Tetsuya , Ohno Hiroshi 
Published: April 2023

AbstractWe aimed to identify gut microbiota that influences body weight by elucidating the association with diets and host genes. Germ-free (GF) mice with and without fecal microbiota transplant (FMT) were fed a normal, high-carbohydrate, or high-fat diet. FMT mice exhibited greater total body weight; adipose tissue and liver weights; blood glucose, insulin, and total cholesterol levels; and oil droplet size than the GF mice, regardless of diet. However, the extent of weight gain and metabolic parameter levels associated with gut microbiota depended on the nutrients ingested. For example, a disaccharide- or polysaccharide-rich diet caused more weight gain than a monosaccharide-rich diet. An unsaturated fatty acid-rich diet had a greater microbial insulin-increasing effect than a saturated fatty acid-rich diet. Perhaps the difference in microbial metabolites produced from substances taken up by the host created metabolic differences. Therefore, we analyzed such dietary influences on gut microbiota, differentially expressed genes between GF and FMT mice, and metabolic factors, including body weight. The results revealed a correlation between increased weight gain, a fat-rich diet, increased Ruminococcaceae abundance, and decreased claudin 22 gene expression. These findings suggest that weight regulation might be possible through the manipulation of the gut microbiota metabolism using the host’s diet.
A Critical Analysis of Standardized Testing in Speech and Language Therapy
Authors: Nair Vishnu KK , Farah Warda , Cushing Ian 
Published: April 2023

Purpose:This review article critically interrogates the history and the current practice of standardized assessment in speech and language therapy. Speech and language assessments utilizing standardized linguistic norms are a critical tool for constructing disability and controlling disabled individuals. Such practices are rooted in a medical model of disability where the linguistic practice(s) of the individual is pathologized to create normalcy and disorder.Method:We examine how these practices are anchored in eugenics and the racist logics of intelligence testing in which racialized populations were rendered as linguistically and biologically inferior.Results:This review article shows how ideologies governing standardized assessments are influenced by racism, ableism, and the nation-state and serve as foundational mechanisms to enable surveillance and capital production. It demonstrates how standard language ideologies are central to standardized testing. Speech and language therapy practices upholding these ideologies contribute to unrestrained wealth generation for the testing industry.Conclusions:The review article ends with a call for clinicians, educators, and researchers to critically examine the relationship between standardized assessment, race, disability, and capitalism in speech-language therapy. This process will contribute toward dismantling the hegemonic role of standardized assessment in oppression and marginalization of speech and language−disabled individuals.