bluuebunny/crossref_metadata_2025_split huggingface dataset:
The History of Conciliar Reception
Authors: Pié-Ninot Salvador 
Published: January 2023

Abstract
This chapter frames the reception of Vatican II in three different macro-periods: from the conclusion of the council until the Extraordinary Bishops’ Synod of 1985 (1965–85); the period of the ‘hermeneutic of reform’ (1986–2012); and what can be termed the ‘Francis effect’ (2013– ). The first stage, from conciliar euphoria to the harmonizing of interpretations of Vatican II at the Synod of Bishops of 1985, led the bishops to issue a final statement under four general principles which will be examined in the first section. The second stage can be characterized as a battle for meaning between the continuity and discontinuity of Vatican II. Benedict XVI’s ‘hermeneutic of reform’ serves as a helpful ‘Formula of Concord’ between the different positive proposals. The third stage, beginning with the pontificate of Francis, can be seen as the beginning of a new phase of reception of the council. His teaching, especially in Evangelii Gaudium (2013), provides an original interpretation of Vatican II. The ‘Francis effect’ moves the Church towards a living experience of the Second Vatican Council through the new experience of Synodality in the Church.
U-box E3 ubiquitin ligase PUB8 attenuates abscisic acid responses during early seedling growth
Authors: Li Zhipeng , Li Shaoqin , Jin Dongjie , Yang Yongping , Pu Zhengyan , Han Xiao , Hu Yanru , Jiang Yanjuan 
Published: January 2023

AbstractABSCISIC ACID-INSENSITIVE3 (ABI3) and ABI5 are 2 crucial transcription factors in abscisic acid (ABA) signaling, and their homeostasis at the protein level plays a decisive role in seed germination and subsequent seedling growth. Here, we found that PLANT U-BOX 8 (PUB8), a U-box E3 ubiquitin ligase, physically interacts with ABI3 and ABI5 and negatively regulates ABA responses during early Arabidopsis (Arabidopsis thaliana) seedling growth. Loss-of-function pub8 mutants were hypersensitive to ABA-inhibited cotyledon greening, while lines overexpressing PUB8 with low levels of ABI5 protein abundance were insensitive to ABA. Genetic analyses showed that ABI3 and ABI5 were required for the ABA-sensitive phenotype of pub8, indicating that PUB8 functions upstream of ABI3 and ABI5 to regulate ABA responses. Biochemical analyses showed that PUB8 can associate with ABI3 and ABI5 for degradation through the ubiquitin-mediated 26S proteasome pathway. Correspondingly, loss-of-function of PUB8 led to enhanced ABI3 and ABI5 stability, while overexpression of PUB8 impaired accumulation of ABI3 and ABI5 in planta. Further phenotypic analysis indicated that PUB8 compromised the function of ABI5 during early seedling growth. Taken together, our results reveal the regulatory role of PUB8 in modulating the early seedling growth by controlling the homeostasis of ABI3 and ABI5.
Resting cytosol Ca2+ level maintained by Ca2+ pumps affects environmental responses in Arabidopsis
Authors: Li Zhan , Harper Jeffrey F , Weigand Chrystle , Hua Jian 
Published: January 2023

AbstractCalcium ion transporting systems control cytosol Ca2+ levels ([Ca2+]cyt) and generate transient calcium (Ca2+) signatures that are key to environmental responses. Here, we report an impact of resting [Ca2+]cyt on plants from the functional study of calmodulin-regulated Ca2+ pumps or Ca2+-ATPases in Arabidopsis (Arabidopsis thaliana). The plasma membrane-localized pumps ACA8 (autoinhibited Ca2+-ATPase) and ACA10, as well as the vacuole-localized pumps ACA4 and ACA11, were critical in maintaining low resting [Ca2+]cyt and essential for plant survival under chilling and heat-stress conditions. Their loss-of-function mutants aca8 aca10 and aca4 aca11 had autoimmunity at normal temperatures, and this deregulated immune activation was enhanced by low temperature, leading to chilling lethality. Furthermore, these mutants showed an elevated resting [Ca2+]cyt, and a reduction of external Ca2+ lowered [Ca2+]cyt and repressed their autoimmunity and cold susceptibility. The aca8 aca10 and the aca4 aca11 mutants were also susceptible to heat, likely resulting from more closed stomata and higher leaf surface temperature than the wild type. These observations support a model in which the regulation of resting [Ca2+]cyt is critical to how plants regulate biotic and abiotic responses.
A 4-week morning light treatment with stable sleep timing for individuals with fibromyalgia: a randomized controlled trial
Authors: Burgess Helen J , Bahl Sonal , Wilensky Katelyn , Spence Emily , Jouppi Riley J , Rizvydeen Muneer , Goldstein Cathy , Kim Hyungjin Myra , Williams David A , Burns John W 
Published: January 2023

Abstract

Objectives
Fibromyalgia is characterized by chronic widespread pain, mood, and sleep disturbance. Pharmacological treatments have modest efficacy and are associated with negative side effects, and alternative approaches are needed. Morning bright light treatment may assist in the management of fibromyalgia as it can reduce depressive symptoms, improve sleep, and advance circadian timing.

Methods
Sixty people with fibromyalgia (58 women, mean age 41.8 ± 13.3 years) were enrolled in a study comparing 4 weeks of a 1-hour daily morning bright light treatment (active treatment) to a morning dim light treatment (comparison treatment). Both light treatments included behavioral procedures to stabilize sleep timing. The morning bright light treatment was expected to produce larger improvements in pain and function than the dim light treatment and larger improvements in potential mediators (mood, sleep, and circadian timing).

Results
Both the bright and dim light treatment groups achieved significant but similar levels of improvement in pain intensity, pain interference, physical function, depressive symptoms, and sleep disturbance. Overall, the sample on average displayed a clinically meaningful improvement in the Fibromyalgia Impact Questionnaire-Revised score (mean reduction of 11.2 points), comparable to that reported following physical exercise treatments. Minimal side effects were observed.

Conclusions
Findings indicate that the effects of a morning bright light treatment did not exceed those of a comparison dim light treatment; yet the changes on average in both conditions revealed clinically meaningful improvements. Future research is warranted to identify what elements of this trial may have contributed to the observed effects.
Shoulder Performance Activity Test (SPAT) for People With Shoulder Pain: Feasibility, Reliability, and Validity
Authors: Sousa Catarina O , Nascimento José Diego S , Pozzi Federico , Kardouni Joseph R , Michener Lori A 
Published: January 2023

Abstract

Objective
The purpose of this study was to assess feasibility, reliability, and validity of a new performance-based test, the Shoulder Performance Activity Test (SPAT).

Methods
People with shoulder pain (n = 93) and without shoulder pain (n = 43) were included. The SPAT consists of overhead reach, hand behind head, and hand behind back tasks, each performed with 20 repetitions and rated by time, pain, and effort. The SPAT scores were summed for time, pain, and effort, and a total score across the 3 tasks. Feasibility was assessed by the percentage of SPAT task completion, test–retest reliability by intraclass correlation coefficient (ICC), standard error measurement, minimal detectable change, and known-groups construct validity by comparing between groups (shoulder pain and no pain) and between shoulders in those with pain.

Results
All participants performed the 3 SPAT tasks. The ICC was 0.74–0.91, and the minimal detectable change was 3.1–4.7 for task scores and 10.0 points for the total score. Individuals with pain presented higher tasks and total scores compared with those without pain. The moderate/severe pain group had higher scores than the low pain and no shoulder pain groups, and the low pain group had higher scores than the no pain group. Scores were higher in the involved shoulder compared with the uninvolved shoulder.

Conclusion
The SPAT is a feasible and reliable performance-based test for use in patients with shoulder pain and can differentiate between individuals with and without pain, among different levels of pain, and between involved and uninvolved shoulders.

Impact
The SPAT provides a standardized method for clinicians to assess shoulder functional performance tasks, which can enable a comprehensive assessment of shoulder disability and clinical decision making. The error metrics can be used to determine meaningful changes in performance.
Learning Health Systems Research Competencies: A Survey of the Rehabilitation Research Community
Authors: McDonough Christine M , Poploski Kathleen M , Anderson Catherine A , Annaswamy Thiru M , Clark Melissa A , Douglas Natalie F , Flores Ann Marie , Freburger Janet K , Hafner Brian J , Hoffman Jeanne M , Kinney Adam R , Ressel Kristin , Sánchez Jennifer , Whitten Margarite J , Resnik Linda 
Published: January 2023

Abstract

Objective
The Learning Health Systems Rehabilitation Research Network (LeaRRn), an NIH-funded rehabilitation research resource center, aims to advance the research capacity of learning health systems (LHSs) within the rehabilitation community. A needs assessment survey was administered to inform development of educational resources.

Methods
The online survey included 55 items addressing interest in and knowledge of 33 LHS research core competencies in 7 domains and additional items on respondent characteristics. Recruitment targeting rehabilitation researchers and health system collaborators was conducted by LeaRRn, LeaRRn health system partners, rehabilitation professional organizations, and research university program directors using email, listservs, and social media announcements.

Results
Of the 650 people who initiated the survey, 410 respondents constituted the study sample. Respondents indicated interest in LHS research and responded to at least 1 competency item and/or demographic question. Two-thirds of the study sample had doctoral research degrees, and one-third reported research as their profession. The most common clinical disciplines were physical therapy (38%), communication sciences and disorders (22%), and occupational therapy (10%). Across all 55 competency items, 95% of respondents expressed “a lot” or “some” interest in learning more, but only 19% reported “a lot” of knowledge. Respondents reported “a lot” of interest in a range of topics, including selecting outcome measures that are meaningful to patients (78%) and implementing research evidence in health systems (75%). “None” or “some” knowledge was reported most often in Systems Science areas such as understanding the interrelationships between financing, organization, delivery, and rehabilitation outcomes (93%) and assessing the extent to which research activities will improve the equity of health systems (93%).

Conclusion
Results from this large survey of the rehabilitation research community indicate strong interest in LHS research competencies and opportunities to advance skills and training.

Impact
Competencies where respondents indicated high interest and limited knowledge can inform development of LHS educational content that is most needed.
The incidence of Kawasaki disease using hospital admissions data for England 2006–2021
Authors: Odingo Myron , Rutter Megan , Bowley Jonathan , Peach Emily J , Lanyon Peter C , Grainge Matthew J , Stillwell Peter , McPhail Sean , Bythell Mary , Aston Jeanette , Stevens Sarah , McCormack Rachael , Brogan Paul , Pearce Fiona A 
Published: January 2023

Abstract

Objective
To describe the incidence of Kawasaki Disease (kDa) between 2006 and 2021 in England.

Methods
We identified all cases in hospital episode statistics with an ICD-10 diagnostic code M303 (for kDa) between 1 April 2006 and 31 March 2021. We validated 83 diagnoses using hospital medical records and found &gt;97% accuracy. We calculated incidence rate ratios (IRRs) using Poisson regression and assessed the influence of age, sex, ethnicity and index of multiple deprivation (IMD). We used Office for National Statistics population estimates for England as the denominator.

Results
We identified a total of 5908 cases of kDa in all children under the age of 16 (mean age 3.8, s.d.=3.2, 95% CI: 3.7, 3.9). Incidence in children aged &lt;5 years was 8.9 (95% CI: 8.6, 9.2)/100 000 person-years; in children aged 5–9, 2.4 (95% CI: 2.3, 2.6)/100 000 person-years; and in children aged 10–15, 0.6 (95% CI: 0.6, 0.7). Male : female ratio was 1.5 : 1. Incidence was higher among non-White than White ethnicities [adjusted IRR 2.1 (2.0–2.2) for Asian, 3.0 (2.8–3.3) for Black and 4.5 (4.2–4.8) for other ethnicities]. The incidence increased with socioeconomic deprivation; the adjusted IRR of the least deprived IMD quintile compared with the most deprived quintile was 0.81 (0.77–0.84).

Conclusions
Incidence rates of kDa derived from hospital admission data in England were higher than in studies relying on clinician reporting. We confirm previous findings on the influence of sex and ethnicity on kDa incidence and observe that there was a higher incidence of kDa within more deprived socioeconomic groups.
Carotid body tumors
Authors: Ratliff Catherine R. , Strider David V. 
Published: January 2023

Abstract

Background:
Carotid body tumors (CBTs) are uncommon neuroendocrine tumors located near the carotid bifurcation within the carotid body. CBTs are slow-growing; affected individuals may remain asymptomatic for years and are often diagnosed incidentally following imaging studies. When present, symptoms are nonspecific. Because incidence is low, retrospective review of CBT case series is an ideal study design for investigating common symptomology, identifying successful diagnostic tools, and evaluating treatment outcomes.

Methods:
This article describes a case series of 11 patients treated for CBTs at an academic medical center in the Southeastern US. A retrospective chart review of 11 patients who had been discharged from the hospital following treatment for CBTs between 2017 and 2021 was conducted. Descriptive statistics were used to delineate the case series.

Results:
There were four males (36%) and seven females (64%) included in the retrospective case series. The age range was 34 to 79 with a mean of 56.73 (standard deviation 16.038). Three patients were found to have a neck mass on physical exam. Additional symptoms included vocal cord paralysis, facial paralysis, ischemic stroke, Bell palsy, dysphonia, and dizziness. Two patients had familial CBTs. Ten patients underwent surgical excision.

Conclusion:
This case series showed that patients with CBTs should be assessed with a combination of history and physical exams along with imaging studies to confirm the diagnosis. Because CBTs may become malignant and metastasize, it is important for NPs to be knowledgeable about presenting symptoms and appropriate diagnostic studies to be able to refer patients to vascular surgeons early to prevent complications.
Inpatient Low-dose Transitions From Full Agonist Opioids Including Methadone Onto Long-acting Depot Buprenorphine: Case Series From a Multicenter Clinical Trial
Authors: Seval Nikhil , Nunez Johnathan , Roth Prerana , Schade Meredith , Strong Michelle , Frank Cynthia A. , Litwin Alain H. , Levin Frances R. , Brady Kathleen T. , Nunes Edward V. , Springer Sandra A. 
Published: January 2023

Objectives
Persons with opioid use disorder (OUD) suffer disproportionately from morbidity and mortality related to serious addiction-related infections requiring hospitalization. Long-acting buprenorphine (LAB) is an underused medication for OUD that may facilitate linkage to care and treatment retention when administered before hospital discharge. Transition onto buprenorphine in the inpatient setting is often complicated by pain, active infection management, potential surgical interventions, and risk of opioid withdrawal in transition from full agonists to a partial agonist.

Methods
The COMMIT Trial is a randomized controlled trial evaluating LAB administered by infectious disease physicians and hospitalists compared with treatment as usual for persons with OUD hospitalized with infections. We report a case series of participants on full agonist opioids including methadone who were transitioned to sublingual buprenorphine using low-dose (microdosing) strategies followed by LAB injection.

Results
Seven participants with current opioid use disorder and life-threatening infections, all with significant concurrent pain and many requiring surgical intervention, underwent low-dose transitions starting at buccal buprenorphine doses ranging from 225 μg to 300 μg 3 times a day on the first day. All were well tolerated with average time to LAB injection of 7.5 days (range, 5–10 days).

Conclusions
Inpatient low-dose buprenorphine transition from full agonist opioids including methadone onto LAB is feasible even in those with complex hospitalizations for concurrent infections and/or surgery. This strategy facilitates dosing of LAB before hospital discharge when risk of opioid relapse and overdose are significant.
Aspects of Patient Experience Associated With Improved Scoliosis Research Society-22 Revised (SRS-22R) and European Quality of Life Five-Dimension Five-Level (EQ-5D-5L) Scores in Patients With Adolescent Idiopathic Scoliosis Managed With Observation or Bracing
Authors: Chua Yi Ling , Toh Alyssa Jia Ning , Tan Xavier Yeow Boon , Pan Daryl Chen Yi , Lee Nicole Kim Luan , Lim Kevin Boon Leong 
Published: January 2023

Study Design.
Prospective cohort study.

Objective.
The purpose of this study was to evaluate the relationship between patient-reported experience measures (PREMs) and patient-reported outcome measures (PROMs) in adolescent idiopathic scoliosis (AIS) managed nonsurgically with bracing or observation.

Summary of Background Data.
PREMs and PROMs are increasingly used to assess the effectiveness of patient-centered health care provision. To date, no study has attempted to study the relationship between PREMs and PROMs in AIS.

Methods.
All patients who visited our one-stop, tertiary center for AIS between 2020 and 2021, were asked to complete pairs of PREMs and PROMs questionnaires. PREMs were evaluated using our institution’s outpatient experience survey adapted from Hospital Consumer Assessment of Healthcare Providers and Systems survey. PROMs were determined via the Scoliosis Research Society-22 revised (SRS-22r) and European Quality of Life Five-Dimension Five-Level (EQ-5D-5L) forms.

Results.
In total, we included 730 patients who completed pairs of PREMs and PROMs questionnaires. 451 patients were treated by observation and 279 were braced. In the observation group, there was no association between patient experience and SRS-22r or EQ-5D-5L scores. In the brace group, improved SRS-22r were associated with higher PREM scores. In particular, having confidence and trust in treating physicians (r=0.34), reporting that their worries and concerns were addressed during treatment (r=0.34) and being taught self-care (r=0.33, P<0.0001 for all) were most highly correlated with better SRS-22r scores.

Conclusions.
In patients with AIS treated with bracing, improved patient experience was positively correlated with better patient reported outcomes, especially if patients' concerns were addressed during treatment and they received supportive care and education on self-care. In contrast, patient experience did not correlate with PROMs in children and adolescents with AIS who were under observation.
Patient, Operator, and Procedural Characteristics of Guidewire Retention as a Complication of Vascular Catheter Insertion
Authors: Kassis Nicholas , Alkukhun Laith , Kravitz Kathleen , Miclea Carolyn , Gill Amanjit , Udeh Chiedozie I. , Mathur Piyush , Hamilton Aaron C. , Lyden Sean P. , Kapadia Samir R. , Khot Umesh N. 
Published: January 2023

OBJECTIVES:
Guidewire retention after intravascular catheter insertion is considered a “never event.” Prior reports attribute this complication to various characteristics including uncooperative patients, operator inexperience, off-hour or emergent insertion, and underutilization of ultrasound guidance. In this descriptive analysis of consecutive events, we assessed the frequency of patient, operator, and procedural factors in guidewire retention.

DESIGN:
Pre-specified observational analysis as part of a quality improvement study of consecutive guidewire retention events across a multihospital health system from August 2007 to October 2015.

SETTING:
Ten hospitals within the Cleveland Clinic Health System in Ohio, United States.

PATIENTS:
Consecutive all-comers who experienced guidewire retention after vascular catheter insertion.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Data were manually obtained from the electronic medical records and reviewed for potential contributing factors for guidewire retention, stratified into patient, operator, and procedural characteristics. A total of 24 events were identified. Overall, the median age was 74 years, 58% were males, and the median body mass index was 26.5 kg/m2. A total of 12 (50%) individuals were sedated during the procedure. Most incidents (10 [42%]) occurred in internal jugular venous access sites. The majority of cases (13 [54%]) were performed or supervised by an attending. Among all cases, three (12%) were performed by first-year trainees, seven (29%) by residents, three (12%) by fellows, and four (17%) by certified nurse practitioners. Overall, 16 (67%) events occurred during regular working hours (8 amto 5 pm). In total, 22 (92%) guidewires were inserted nonemergently, with two (8%) during a cardiac arrest. Ultrasound guidance was used in all but one case.

CONCLUSIONS:
Guidewire retention can occur even in the presence of optimal patient, operator, and procedural circumstances, highlighting the need for constant awareness of this risk. Efforts to eliminate this important complication will require attention to issues surrounding the technical performance of the procedure.
Relationship Between Skeletal Muscle Quality and Hospital-Acquired Disability in Patients With Sepsis Admitted to the ICU: A Pilot Study
Authors: Takahashi Yuta , Morisawa Tomoyuki , Okamoto Hiroshi , Matsumoto Noriko , Saitoh Masakazu , Takahashi Tetsuya , Fujiwara Toshiyuki 
Published: January 2023

IMPORTANCE:
Early risk assessment of functional decline in patients with sepsis is clinically challenging. Recently, there is increasing interest in the nonvolitional evaluation of skeletal muscle quality.

OBJECTIVES:
The aim of this study was to assess the relationship between skeletal muscle quality and functional decline after intensive care.

DESIGN, SETTING, AND PARTICIPANTS:
This pilot study was a single-center prospective observational study conducted from March 2021 to February 2022. We included consecutive patients with sepsis who were admitted to our ICU.

MAIN OUTCOMES AND MEASURES:
The primary outcome was hospital-acquired disability (HAD), which is defined as a decrease in the Barthel index score of at least 5 points from pre-hospital to hospital discharge. Muscle quality was assessed by: 1) muscle echogenicity with ultrasound and 2) phase angle (PhA) with bioelectrical impedance analysis, both of which were measured on ICU days less than 3, 3–5, 5–7, 7–10, and 10–14. We compared longitudinal changes in muscle echogenicity and PhA between the HAD and non-HAD groups using two-way repeated measures analysis of variance with mixed models.

RESULTS:
Among the 22 patients, 7 (31.8%) had HAD. Muscle echogenicity was higher in the HAD group than in the non-HAD group (p < 0.001); however, no interaction effects were found between the two groups (p = 0.189). PhA showed a main effect on each evaluation day in patients (p = 0.040) and a significant interaction effect between the groups, including an early decreased pattern in the HAD group (p = 0.036).

CONCLUSIONS AND RELEVANCE:
Higher muscle echogenicity and a decreased PhA pattern are related to HAD. Noninvasive assessment of muscle quality using ultrasound and bioelectrical impedance analysis may be useful in predicting the functional prognosis of patients with sepsis.