bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse childhood experiences in children with fetal alcohol spectrum disorders and their effects on behavior
Authors: Kautz‐Turnbull Carson , Rockhold Madeline , Handley Elizabeth D. , Olson Heather Carmichael , Petrenko Christie 
Published: February 2023

AbstractBackgroundChildren with fetal alcohol spectrum disorders (FASD) have high rates of adverse childhood experiences (ACEs). ACEs are associated with a wide range of health outcomes including difficulty with behavior regulation, an important intervention target. However, the effect of ACEs on different areas of behavior has not been well characterized in children with disabilities. This study describes ACEs in children with FASD and how they impact behavior problems.MethodsA convenience sample of 87 caregivers of children (aged 3 to 12) with FASD participating in an intervention study reported on their children's ACEs using the ACEs Questionnaire and behavior problems on the Eyberg Child Behavior Inventory (ECBI). A theorized three‐factor structure of the ECBI (Oppositional Behavior, Attention Problems, and Conduct Problems) was investigated. Data were analyzed using Pearson correlations and linear regression.ResultsOn average, caregivers endorsed 3.10 (SD = 2.99) ACEs experienced by their children. The two most frequently endorsed ACE risk factors were having lived with a household member with a mental health disorder, followed by having lived with a household member with a substance use disorder. Higher total ACEs score significantly predicted a greater overall frequency of child behavior (intensity scale), but not whether the caregiver perceived the behavior to be a problem (problem scale) on the ECBI. No other variable significantly predicted the frequency of children's disruptive behavior. Exploratory regressions indicated that a higher ACEs score significantly predicted greater Conduct Problems. Total ACEs score was not associated with Attention Problems or Oppositional Behavior.DiscussionChildren with FASD are at risk for ACEs, and those with higher ACEs had a greater frequency of problem behavior on the ECBI, especially conduct problems. Findings emphasize the need for trauma‐informed clinical care for children with FASD and increased accessibility of care. Future research should examine potential mechanisms that underlie the relationship between ACEs and behavior problems to optimally inform interventions.
Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans
Authors: Naps Michelle S. , Leong Shirley H. , Hartwell Emily E. , Rentsch Christopher T. , Kranzler Henry R. 
Published: February 2023

AbstractBackgroundTopiramate, which is increasingly being used to treat alcohol use disorder (AUD), is commonly associated with reduced serum bicarbonate concentrations. However, estimates of the prevalence and magnitude of this effect are from small samples and do not address whether topiramate's effects on acid–base balance differ in the presence of an AUD or by topiramate dosage.MethodsVeterans Health Administration electronic health record (EHR) data were used to identify patients with a minimum of 180 days of topiramate prescription for any indication and a propensity score‐matched control group. We differentiated patients into two subgroups based on the presence of a diagnosis of AUD in the EHR. Baseline alcohol consumption was determined using Alcohol Use Disorders Identification Test–Consumption (AUDIT‐C) scores in the EHR. Analysis also included a three‐level measure representing mean daily dosage. The topiramate‐associated changes in serum bicarbonate concentration were estimated in difference‐in‐differences linear regression models. A serum bicarbonate concentration <17 mEq/L was considered to represent possible clinically significant metabolic acidosis.ResultsThe cohort comprised 4287 topiramate‐treated patients and 5992 propensity score‐matched controls with a mean follow‐up period of 417 days. The mean topiramate‐associated reductions in serum bicarbonate concentration were <2 mEq/L in the low (≤88.75), medium (>88.75 and ≤141.70), and high (>141.70) mg/day dosage tertiles, irrespective of AUD history. Concentrations <17 mEq/L occurred in 1.1% of topiramate‐treated patients and 0.3% of controls and were not associated with alcohol consumption or an AUD diagnosis.ConclusionsThe excess prevalence of metabolic acidosis associated with topiramate treatment does not differ with dosage, alcohol consumption, or the presence of an AUD. Baseline and periodic serum bicarbonate concentration measurements are recommended during topiramate therapy. Patients prescribed topiramate should be educated about the symptoms of metabolic acidosis and urged to report their occurrence promptly to a healthcare provider.
An investigation of the utility of the Australian Guide to the Diagnosis of Fetal Alcohol Spectrum Disorder in young children
Authors: Dawe Sharon , Eggins Elizabeth , Betts Joseph , Webster Heidi , Pomario Tania , Doak Jessica , Chandler‐Mather Ned , Hatzis Denise , Till Haydn , Harnett Paul , Wood Andrew , Shelton Doug 
Published: February 2023

AbstractBackgroundEarly diagnosis of children with fetal alcohol spectrum disorder (FASD) assists in implementing critical early support. The challenge lies in having a diagnostic process that enables valid and reliable assessment of domains of functioning in young children, with the added complexity that many children will also have co‐occurring exposure to childhood adversity that is likely to impact these domains.MethodsThe aim of this study was to test a diagnostic assessment of FASD in young children using the Australian Guide to the Diagnosis of FASD. Ninety‐four children (aged 3 to 7 years) with confirmed or suspected prenatal alcohol exposure were referred to two specialist FASD clinics for assessment in Queensland, Australia.ResultsThere was a significant risk profile with 68.1% (n = 64) children having had contact with child protection services, and most children living in kinship (n = 22, 27.7%) or foster (n = 36, 40.4%) care. Forty‐one percent of the children were Indigenous Australians. The majority (64.9%, n = 61) of children met criteria for FASD, 30.9% were classified as “At Risk” for FASD (n = 29), and 4.3% received no FASD diagnosis (n = 4). Only 4 (4%) children were rated as severe for the brain domain. Over 60% of children (n = 58) had two or more comorbid diagnoses. Sensitivity analyses indicated that the removal of comorbid diagnoses in the Attention, Affect Regulation, or Adaptive Functioning domains resulted in a change in 7 of 47 cases (15%) to an “At Risk” designation.ConclusionsThese results highlight the complexity of presentation and the extent of impairment in the sample. The use of comorbid diagnoses to substantiate a “severe” designation in specific neurodevelopmental domains raises the question of whether there were false‐positive diagnoses. The complexity of determining causal relationships between exposure to PAE and early life adversity on developmental outcomes continues to be a challenge in this young population.
Dutch professionals' discussion preferences with the parents of extremely premature infants varied, but the trend was towards shared decision‐making
Authors: Geurtzen R. , De Proost L. , Verhagen A. A. E. , Reiss I. K. M. , Hogeveen M. , Verweij E. J. T. 
Published: February 2023

AbstractAimWe explored professionals' views on sharing decision‐making with parents before and after an extremely preterm birth and what healthcare professionals considered severe outcomes.MethodsA nationwide, multi‐centre online survey was carried out among a wide range of perinatal healthcare professionals in the Netherlands from 4 November 2020 to 10 January 2021. The medical chairs of all nine Dutch Level III and IV perinatal centres helped to disseminate the survey link.ResultsWe received 769 survey responses. Most respondents (53%) preferred to place equal emphasis on two treatment options during shared prenatal decision‐making: early intensive care or palliative comfort care. The majority (61%) wanted to include a conditional intensive care trial as a third treatment option, but 25% disagreed. Most (78%) felt that healthcare professionals were responsible for initiating postnatal conversations to justify continuing or withdrawing neonatal intensive care if complications were associated with poor outcomes. Finally, 43% were satisfied with the current definitions of severe long‐term outcomes, 41% were unsure and there were numerous for a broader definition.ConclusionAlthough Dutch professionals expressed diverse preferences on how to reach decisions about extremely premature infants, we observed a trend towards shared decision‐making with parents. These results could inform future guidelines.
Effect of heating bovine colostrum at 60°C for 90′ on colostrum quality and, the health and growth characteristics of Holstein dairy calves
Authors: Zakian A , Rasooli A , Nouri M , Ghorbanpour M , Khosravi M , Constable PD , Moazeni M 
Published: February 2023

AimsThe major objective of this study was to investigate the efficacy of heat‐treating colostrum on the subsequent growth characteristics (weight gain, body size, dry matter intake and feed efficiency rate) and health of Holstein calves.MethodsA total of 1200 neonatal Holstein calves on one commercial dairy farm were enrolled. The calves were divided into heat‐treated (60°C for 90 min) and unheated (raw) colostrum groups. Calf serum IgG and total protein concentrations were measured before and after colostrum consumption. Health characteristics and disease prevalence were recorded during the suckling period.ResultsConsumption of heat‐treated colostrum led to increased serum IgG (P < 0.0001) and total protein (P < 0.0001) concentrations, increased apparent efficacy of IgG absorption (P < 0.0001) and increased general health condition, weight gain (P < 0.0001) and clinical performance.Conclusions and clinical relevanceHeat‐treatment of colostrum is an effective method to improve health and increase growth characteristics (weight gain, body size, dry matter intake and feed efficiency rate) of neonatal dairy calves, most likely by decreasing microbial load and facilitating IgG absorption.
Top management teams' foreign experience, environmental regulation, and firms' green innovation
Authors: Zhang Xuejiao , Zhao Qingyang , Li Wanfu , Wang Yu 
Published: February 2023

AbstractIn this study, we examine how top management teams' foreign experience affects firms' green innovation performance and what role environmental regulation plays in their association. Using a large data set on firms' green patents and foreign work or education experience of top management teams from China, we find robust evidence that firms whose top management team members have foreign experience achieve significantly more green patents, and this positive relationship is more pronounced for firms subject to strong environmental regulation. Our findings indicate that via enhancing firms' green innovation performance, top management teams' foreign experience has a positive corporate governance effect on advancing sustainable social development, and environmental regulation is helpful to promote this effect.
Bayesian hierarchical response time modelling—A tutorial
Authors: Koenig Christoph , Becker Benjamin , Ulitzsch Esther 
Published: February 2023

AbstractResponse time modelling is developing rapidly in the field of psychometrics, and its use is growing in psychology. In most applications, component models for response times are modelled jointly with component models for responses, thereby stabilizing estimation of item response theory model parameters and enabling research on a variety of novel substantive research questions. Bayesian estimation techniques facilitate estimation of response time models. Implementations of these models in standard statistical software, however, are still sparse. In this accessible tutorial, we discuss one of the most common response time models—the lognormal response time model—embedded in the hierarchical framework by van der Linden (2007). We provide detailed guidance on how to specify and estimate this model in a Bayesian hierarchical context. One of the strengths of the presented model is its flexibility, which makes it possible to adapt and extend the model according to researchers' needs and hypotheses on response behaviour. We illustrate this based on three recent model extensions: (a) application to non‐cognitive data incorporating the distance‐difficulty hypothesis, (b) modelling conditional dependencies between response times and responses, and (c) identifying differences in response behaviour via mixture modelling. This tutorial aims to provide a better understanding of the use and utility of response time models, showcases how these models can easily be adapted and extended, and contributes to a growing need for these models to answer novel substantive research questions in both non‐cognitive and cognitive contexts.
Navigating the space between politics and administration: The informal practices of Ontario school board trustees
Authors: Payler Adam , Piscitelli Anthony , Geobey Sean 
Published: February 2023

AbstractThrough interviews with 25 school board trustees in Ontario, this article contributes to the growing literature that explores the politics‐administration dichotomy at the local government level in Canada. While existing literature is oriented from the perspective of the local government administrator, we examine the relations between local government politicians and administrators from the orientation of the former to determine how they navigate the dichotomy, particularly in a context where it is arguably more contested. We identify six informal practices trustees adopt in representing constituents and confronting tensions inherent in their role, namely:navigating, influencing, listening, translating, informing, anduploading.
Minimally good life and the human right to health
Authors: Hirose Iwao 
Published: February 2023

AbstractIn Global Health Impact: Extending Access to Essential Medicines, Nicole Hassoun argues that the concept of a minimally good life grounds the human right to health, which in turn implies the human right to access essential medicines in developing countries. This article argues that Hassoun's argument must be revised. If the temporal unit of a minimally good life is identified, her argument faces a substantive problem, which undermines an important part of her argument. This article then proposes a solution to this problem. If this proposed solution is accepted, Hassoun's project turns out to be more radical than her argument is supposed to be.
Biallelic mutations in LSS in autosomal‐recessive mutilating palmoplantar keratoderma
Authors: Zhou Shengru , Jiang Xingyuan , Zhu Yuhao , Yang Jianqiu , Yuan Chunyu , Chen Min , Zhou Qianqian , Lin Zhimiao , Li Min 
Published: February 2023

AbstractMutilating palmoplantar keratoderma (PPK) is a heterogeneous genetic disease that poses enormous challenges to clinical diagnosis and genetic counselling. Lanosterol synthase (LSS) gene encodes LSS involved in the biosynthesis pathway of cholesterol. Biallelic mutations in LSS were found to be related to diseases such as cataracts, hypotrichosis and palmoplantar keratoderma‐congenital alopecia syndrome. The aim of this study was to investigate the contribution of the LSS mutation to mutilating PPK in a Chinese patient. The clinical and molecular characteristics of the patient were evaluated. A 38‐year‐old male patient with mutilating PPK was recruited in this study. We identified biallelic variants in the LSS gene (c.683C > T, p.Thr228Ile and c.779G > A, p.Arg260His). Immunoblotting revealed that the Arg260His mutant showed a significantly reduced expression level while Thr228Ile showed an expression level similar to that of the wild type. Thin layer chromatography revealed that mutant Thr228Ile retained partial enzymatic activity and mutant Arg260His did not show any catalytic activity. Our findings show the correlation between LSS mutations and mutilating PPK.
Nutraceutical strategies for alleviation of UVB phototoxicity
Authors: McCarty Mark F. , Benzvi Carina , Vojdani Aristo , Lerner Aaron 
Published: February 2023

AbstractUltraviolet B exposure to keratinocytes promotes carcinogenesis by inducing pyrimidine dimer lesions in DNA, suppressing the nucleotide excision repair mechanism required to fix them, inhibiting the apoptosis required for the elimination of initiated cells, and driving cellular proliferation. Certain nutraceuticals – most prominently spirulina, soy isoflavones, long‐chain omega‐3 fatty acids, the green tea catechin epigallocatechin gallate (EGCG) and Polypodium leucotomos extract – have been shown to oppose photocarcinogenesis, as well as sunburn and photoaging, in UVB‐exposed hairless mice. It is proposed that spirulina provides protection in this regard via phycocyanobilin‐mediated inhibition of Nox1‐dependent NADPH oxidase; that soy isoflavones do so by opposing NF‐κB transcriptional activity via oestrogen receptor‐beta; that the benefit of eicosapentaenoic acid reflects decreased production of prostaglandin E2; and that EGCG counters UVB‐mediated phototoxicity via inhibition of the epidermal growth factor receptor. The prospects for practical nutraceutical down‐regulation of photocarcinogenesis, sunburn, and photoaging appear favourable.
RETRACTED: The analysis of green advertisement communication strategy based on deep factorization machine deep learning model under supply chain management
Authors: Yu Xue , Zhu Yunfei , Jia Congcong , Lu Wanqiu , Xu Hao 
Published: February 2023

AbstractArtificial intelligence (AI) technology has brought new reconstruction opportunities for the intelligence of the advertisement industry through the help of AI technologies such as machine learning and deep learning. First, the relationship between AI and the attractiveness of green advertisements is investigated, and the influence of different AI technologies in green advertisements on consumers' perception of the attractiveness of green advertisements is summarized. Second, based on the green advertisement dissemination rate data set, the data visualization exploration is carried out, and the data deletion and coding processing are carried out aiming at different characteristic variables. Finally, according to the problems existing in the current green advertisement communication and the high‐dimensional and sparse characteristics of the communication rate data set. In this paper, based on Deep FM (Factorization Machine), Gradient Boost Decision Tree (GBDT) is added to assist the experiment, and the prediction performance of green advertising communication is tested. The results are as follows. (1) Different AI expressions in green advertisements will affect consumers' perception of the attractiveness of green advertisements. (2) The prediction ability of Deep FM model after feature engineering is better than that of data cleaning only. The prediction effect of the model is obviously improved. The purpose of this paper is to integrate green advertising media communication into the ecological concept of harmonious coexistence between man and nature, strengthen the political belief of ecological civilization construction, and conform to the communication trend of today's severe ecological situation.
Effects of clarithromycin on the pharmacokinetics of tacrolimus and expression of CYP3A4 and P‐glycoprotein in rats
Authors: Wen Jinhua , ChenYang  , Zhao Menghua , Hu Weiqiang , Xiao Yu Wei 
Published: February 2023

AbstractThe objective of this study was to investigate the effect of clarithromycin on the pharmacokinetics of tacrolimus in rats and better understand its mechanism. In the control group (n = 6), rats received a single oral dose of 1 mg tacrolimus on day 6. In the experimental group (n = 6), rats received 0.25 g of clarithromycin daily for five consecutive days and then a single oral dose of 1 mg tacrolimus on day 6. Orbital venous blood (250 μL) was collected at 0, 0.25, 0.50, 0.75, 1, 2, 4, 8, 12, and 24 h before and after tacrolimus administration. Blood drug concentrations were detected via mass spectrometry. Small intestine and liver tissue samples were collected after rats were euthanized via dislocation, and CYP3A4 and P‐glycoprotein (P‐gp) protein expression was determined using western blotting. Clarithromycin increased the blood tacrolimus concentration and affected its pharmacokinetic properties in rats. Compared with those in the control group, the AUC0–24, AUC0–∞, AUMC(0–t), and AUMC(0–∞) of tacrolimus in the experimental group were significantly increased, whereas the CLz/F was significantly lower (P < 0.01). Simultaneously, clarithromycin significantly inhibited CYP3A4 and P‐gp expression in the liver and intestine. Protein expression of CYP3A4 and P‐gp in the liver and the intestinal tract was significantly downregulated in the intervention group compared with that in the control group. Clarithromycin significantly inhibited the protein expression of CYP3A4 and P‐gp in the liver and intestine, thereby increasing the mean blood concentration and significantly increasing the AUC of tacrolimus.
Single‐cell dissection reveals the role of DNA damage response patterns in tumor microenvironment components contributing to colorectal cancer progression and immunotherapy
Authors: Shen Xin , Mo Shaocong , Wang Yulin , Lin Lingxi , Liu YunPeng , Weng Meilin , Gu Wenchao , Nakajima Takahito 
Published: February 2023

AbstractColorectal cancer (CRC) is one of the leading malignant cancers. DNA damage response (DDR), referring to the molecular process of DNA damage, is emerging as a promising field in targeted cancer therapy. However, the engagement of DDR in the remodeling of the tumor microenvironment is rarely studied. In this study, by sequential nonnegative matrix factorization (NMF) algorithm, pseudotime analysis, cell–cell interaction analysis, and SCENIC analysis, we have shown that DDR genes demonstrate various patterns among different cell types in CRC TME (tumor microenvironment), especially in epithelial cells, cancer‐associated fibroblasts, CD8+ T cells, tumor‐associated macrophages, which enhance the intensity of intercellular communication and transcription factor activation. Furthermore, based on the newly identified DDR‐related TME signatures, cell subtypes including MNAT+CD8+T_cells‐C5, POLR2E+Mac‐C10, HMGB2+Epi‐C4, HMGB1+Mac‐C11, PER1+Mac‐C5, PER1+CD8+T_cells‐C1, POLR2A+Mac‐C1, TDG+Epi‐C5, TDG+CD8+T_cells‐C8 are determined as critical prognostic factors for CRC patients and predictors of immune checkpoint blockade (ICB) therapy efficacy in two public CRC cohorts, TCGA‐COAD and GSE39582. Our novel and systematic analysis on the level of the single‐cell analysis has revealed the unique role of DDR in remodeling CRC TME for the first time, facilitating the prediction of prognosis and guidance of personalized ICB regimens in CRC.