bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis
Authors: Abd-Elmawla Mai A. , Ghaiad Heba R. , Gad Enas S. , Ahmed Kawkab A. , Abdelmonem Maha 
Published: July 2023

AbstractIvermectin is a US Food and Drug Administration (FDA)-approved antiparasitic agent with antiviral and anti-inflammatory properties. Although recent studies reported the possible anti-inflammatory activity of ivermectin in respiratory injuries, its potential therapeutic effect on pulmonary fibrosis (PF) has not been investigated. This study aimed to explore the ability of ivermectin (0.6 mg/kg) to alleviate bleomycin-induced biochemical derangements and histological changes in an experimental PF rat model. This can provide the means to validate the clinical utility of ivermectin as a treatment option for idiopathic PF. The results showed that ivermectin mitigated the bleomycin-evoked pulmonary injury, as manifested by the reduced infiltration of inflammatory cells, as well as decreased the inflammation and fibrosis scores. Intriguingly, ivermectin decreased collagen fiber deposition and suppressed transforming growth factor-β1 (TGF-β1) and fibronectin protein expression, highlighting its anti-fibrotic activity. This study revealed for the first time that ivermectin can suppress the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome, as manifested by the reduced gene expression of NLRP3 and the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), with a subsequent decline in the interleukin-1β (IL-1β) level. In addition, ivermectin inhibited the expression of intracellular nuclear factor-κB (NF-κB) and hypoxia-inducible factor-1α (HIF-1α) proteins along with lowering the oxidative stress and apoptotic markers. Altogether, this study revealed that ivermectin could ameliorate pulmonary inflammation and fibrosis induced by bleomycin. These beneficial effects were mediated, at least partly, via the downregulation of TGF-β1 and fibronectin, as well as the suppression of NLRP3 inflammasome through modulating the expression of HIF-1α and NF-κB.
Designing and Implementing a Professional Programme for ICLHE Teachers: Beyond Linguistic and Communicative Competence
Authors: Gil Vicky , Dueñas Pilar Mur 
Published: July 2023

English Medium Instruction (EMI) is being fostered by universities across the world to promote their internationalization with an increasing number of courses taught through English both at graduate and postgraduate level. This requires university lecturers to be offered opportunities for professional development. It is the aim of this paper to present an extended training programme -CLIC@unizar (Content and Language Integrated Competences at the Universidad de Zaragoza)- developed at our institution which seeks to foster not only the communicative skills but also the pedagogical skills of those lecturers teaching through the medium of English or who are planning to do so. The training itinerary is grounded on previous research on EMI professional development programmes, English for Academic Purposes (EAP) and English for Specific Purposes (ESP), and methodological principles promoting the students’ active role and their development of communication and digital competences. The use of digital tools and technologies which promote online collaboration, especially HyperDocs and Google Apps for Education (mostly Google Docs, Google Slides, and Google Forms), has been integrated in the itinerary following the SAMR Model (Puentedura, 2013). The use of these digital tools has allowed us to include multimodal ways to provide participants with input, make them interact with the material, with us and among themselves, and produce output as demonstrations of their learning. It is essential to make ICLHE (Integrating Content and Language in Higher Education) teachers aware of their need to adapt their methodology or adopt new ones to be effective in their teaching in an L2.
Isolasi dan Uji Aktivitas Selulolitik Bakteri Asal Limbah Bagas
Authors: Dewi Chusniasih  , Erma Suryanti  , Erina Safitri  
Published: July 2023

Bagasse is one of the by-products of granulated sugar industries or processed beverages that become waste in the environment. The bagasse will be overgrown by cellulolytic bacteria that produce cellulase enzymes. This study aims to isolate, characterize, and measure bacterial cellulase activity qualitatively and quantitatively. The research phase included isolation and characterization of bacteria, qualitative cellulase activity test, preparing standard curves and bacterial growth curves, crude extract cellulase production, constructing standard glucose curves, quantitative enzyme activity tests, and data analysis. Six isolates with macroscopic characteristics varied in color, elevation, margins, and colony shape; three bacillus isolates, one short bacillus isolate, and two cocci isolates were obtained. All isolates showed positive test results of amylum, triple sugar iron agar, and catalase; five citrate-positive isolates, and three motile-positive isolates. From the cellulase qualitative test, two bacterial isolates had the highest cellulolytic index, namely AT1 (1.79) and BAW3 (1.72) on 0.5% CMC media. The quantitative cellulase test results of the two selected isolates were 0.01176 U/mL for AT1 and 0.01170 U/mL for BAW3, both of which are still classified as low degradation capabilities.

Keywords: cellulase activity, cellulolytic index, Sugarcane waste
Respons Fisiologis Sapi Pedaging terhadap Pengabutan Air Menggunakan Sprinkler Water
Authors: Santoso Koekoeh , Tarigan Aldo Febriano , Komariah  
Published: July 2023

Indonesia is facing the problem of low productivity of cattle. To increase the productivity of cattle producer, it can actually be done by relocating the cattle to the comfort zone by observing the physiological response. The purpose of this research is to evaluate the effects of misting cattle’s environment by using water sprinkler on the physiological response and the microclimate of the cattle’s shed. The design used was a paired T-test for physiological and microclimate response variables with 5 replications and a completely randomized design to determine the difference between body surface temperatures. The observations were conducted before water misting and after water misting. The results showed that treatment of misting water in the afternoon significantly decreased (P<0.05) the variables of cage temperature, humidity, temperature humidity index, rectal temperature, respiratory rate, and heart rate. Water misting in the afternoon in cattle produced a good effect on all physiological response variables.

Keywords: beef cattle, pen microclimate, physiological responses, water sprinkler
Structural Equation Model - Parsial Least Square Faktor-Faktor yang Memengaruhi Penjualan Coffee Shop Bacarito Kopi di Kota Padang
Authors: Sumardi Vilda Ayuni , Syarfi Ira Wahyuni , Analia Devi 
Published: July 2023

This study aims to analyze the factors that affect sales of coffee shop Bacarito Kopi in Padang City. The research method used is a survey method. Consumers who are used as respondents are determined by accidental sampling with a total of 70 respondents. The data were obtained through interview guides and distributing questionnaires using a likert scale. The data analysis used is descriptive qualitative and quantitative analysis. Based on the research results, it is known that in carrying out sales activities, Bacarito Kopi has paid attention to controlled environmental factors, namely aspects of the marketing mix, consisting of price, promotion, place or distribution, and product quality. Other efforts made by Bacarito Kopi in conducting sales activities are improving the company’s performance by providing optimal service to the consumers, innovating to survive during intense competition, and expanding the market by opening business branches, and utilizing distribution intermediaries to expand the market. Based on the tests conducted on the research variables using the SEM-PLS analysis method with smartPLS software, it shows that the factors that have a significant effect on the sales of coffee shop Bacarito Kopi in Padang City are the seller’s ability (X1), competition (X2), product quality (X3), price (X4), and promotion (X5).

Keywords: sales, marketing mix, coffee, bacarito kopi
Inventarisasi Jenis Tumbuhan Paku di Hutan Watumbolo, Kabupaten Sumba Barat Daya
Authors: Rafael Andriani , Daud Yanti , Hungu Octaviani 
Published: July 2023

Indonesia is a tropical country that has high plant biodiversity. One of the plant groups that are rich in species are ferns. Ferns still exist until now and estimated at 10.000 species, which 3.000 species are grown out in Indonesia. Watumbolo forest is located in South West Sumba, with the average temperature ranges from 21-34°C, therefore the varians types of plants grow well in this forest, including ferns. The aim of this study was to identify the types of ferns found in the Watumbolo forest. Observations were also made on environmental conditions which included: air temperature, light intensity, soil moisture, and soil pH. This research was conducted using descriptive exploration method. The results obtained 18 species of ferns, namely: Asplenium nidus, Gleichenia linearis, Blechnum orientale, Davallia denticulata, Nephrolepis biserrata, Drynaria quercifolia, Drymoglossum piloselloides, Drynaria parishii, Nephrolepis hirsutula, Angiopteris evecta, Cyclosorus interruptus, Christella subpubescens, Lygodium microphyllum, Lygodium palmatum, Schizaea digitata, Selaginella plana, Lycopodium cernuum, and Psilotum nudum. Therefore, the results of temperature measurements in Watumbolo forest were between 22-28°C, air humidity 56-70%, light intensity 1069lux-6116lux, soil pH 7, and soil moisture 70-72%.

Keywords: ferns, South West Sumba, Watumbolo Forest
Peranan Teknologi Proses Pengolahan Pangan dalam Penurunan Alergenisitas Kerang-kerangan: Meta-analisis
Authors: Alia Andi Nadya Tita , Palupi Nurheni Sri , Giriwono Puspo Edi 
Published: July 2023

Shellfish is widely consumed globally, one of the main reasons is because it contains good nutrition for health. The increased consumption also leads to adverse health problems such as food allergy. Food allergy is hypersensitivity reaction of the immune system caused by consumption or exposure to food. Various food processing methods has been proven to alter shellfish allergenicity with different effectiveness. This study aims to determine the most effective processing method to reduce shellfish allergenicity through meta-analysis. In total of 19 articles were obtained using PRISMA diagram, with publication year range 2006-2020. Data were analyzed to determine Standardized Mean Difference (SMD) with 95% confidence interval. Moist heating, high hydrostatic pressure, irradiation, and ultrasound processing have significant effect (p < 0,05) in reducing shellfish allergenicity. Meanwhile, boiling and roasting processing did not have a significant effect. Based on the results of the meta-analysis, high hydrostatic pressure is the most effective method in reducing shellfish allergenicity because it has the highest effect size value with -7,25 (95% CI: -9,11 s.d. -5,4; p < 0,00001).

Keywords: allergenicity, food processing, meta-analysis, shellfish
Determinan Terpilih untuk Kualitas Air Embung pada Lahan Tadah Hujan di Karanganyar, Jawa Tengah
Authors: Achmad Adi Surya Sustama  , Komariah Komariah , Lukito Arwa Farida , Sumani Sumani , Dwi Priyo Ariyanto  , Widyatmani Sih Dewi  
Published: July 2023

Water conservation is needed to overcome the shortage of irrigation water through harvesting rainwater on rainfed land using small farm reservoir. Intensive agricultural activities cause a reduction in land resources which disrupts hydrological functions (water quantity and quality). This study aims to determine the selected parameters for small farm reservoir water quality and identify water quality based on irrigation water standards according to FAO (1994) and PP No. 82 of 2001. The research was conducted from March to December 2014 in Karanganyar Regency, Central Java Province. This study used a descriptive exploratory survey method with purposive sampling. Water quality data was analyzed using Principal Components Analysis (Multivariate Test) MINITAB 16 to determine the main components as the selected determinants. Furthermore, based on the results of the PCA analysis, 5 variables were obtained whose eigenvalue proportions met the main criteria, including DHL of 0.467; SAR of 0.542; pH of 0.538; Actual Savings Ratio (ASR) of 0.662; and water-air temperature deviation of 0.612. Furthermore, a match is made between the selected determinant measurement data and the water quality standard. The results of matching to the selected determinants for water quality in the reservoir have met the water quality standards for irrigation based on FAO (1994) and Government Regulation no. 82 (2001). The soil characteristics of the catchment area also affect water quality because in rainwater harvesting, surface runoff in the catchment area will flow and be accommodated by the small farm reservoir.

Keywords: water quality, small farm reservoir, PCA, water conservation, rainfall harvesting
DeFi, Blockchain and Cryptocurrencies: Proposing a Global Money Matrix for the Blockchain Era
Authors: Tayazime Jihane , Moutahaddib Aziz 
Published: July 2023

Unlike early civilizations with an entire economy built around agriculture and the practicality of the barter system, today's complex economies require immediate, low-cost transactions. The digitalization of transactions is helping economies develop through various new assets and currencies. The appearance of DeFi, CBDC’s, and many blockchain based systems has created a bit of a debate among researchers. Consequently, the matter maintains a certain ambiguity, which requires more research. In this paper, we will be discussing how blockchain is revolutionizing the financial sector, by creating decentralized finance and central banks’ digital currencies. We will then propose a new global money matrix starting with a short literature review of existing definitions and categorizations since there still is a lack of understanding and standardization of currency categories, especially digital currencies. Then we will do the same for CBDC by categorizing it by component: participants, categories, and application scenarios.
Effets du Niveau d’Instruction de la Mère sur l’État Nutritionnel des Enfants de Moins de Cinq ans au Bénin
Authors: Attanasso Marie Odile , Adéchinan Aminou Fawaz A. , Hounkpevi Patrice Konassou 
Published: July 2023

Se basant sur la théorie de l’allocation du temps de Becker (1965), cet article vise à examiner les effets du niveau d’instruction de la mère sur l’état nutritionnel des enfants de moins de cinq ans au Bénin. Utilisant les données issues de l’enquête démographique et de santé (EDSB-V) de 2018 portant sur un échantillon de 11631 enfants de moins de cinq ans, il adopte une stratégie d’estimation qui contrôle le biais de sélection et l’endogénéité potentielle du niveau d’instruction de la mère pour examiner l’effet du niveau d’instruction de la mère sur l’état nutritionnel de l’enfant. Les résultats indiquent que l’instruction de la mère est un facteur déterminant de l’état nutritionnel des enfants au Bénin. L’effet est plus important et robuste sur le retard de croissance, l’insuffisance pondérale et l’émaciation. Aussi, le niveau d’instruction des mères nécessaire pour faire la réduction significative de la malnutrition infantile est-il au moins le niveau secondaire. Les résultats obtenus montrent que les politiques de scolarisation des femmes doivent être incorporées dans les stratégies nationales de nutrition.

Based on a theory of the allocation of time Becker (1965), this study aims to examine the effects of the mother’s education level on the children’s nutritional status under five in Benin. Using data from the 2018 Demographic and Health Survey (EDSB-V) on a sample of 11.631 children under the age of five, this work adopts an estimation strategy that controls for selection bias and potential endogeneity of the mother's education level to examine the effect of the mother's education and children's nutritional status. The findings indicate that the mother’s education is a determining factor in the children’s nutritional status in Benin. The effect is larger and more robust on stunting, underweight, and wasting. In addition, the mother’s education level needed to make significant reductions in child malnutrition is at least high school. The obtained results show that women’s education policies must be incorporated into national nutrition strategies.
Effecsts of Uncertainty on Domestic Private Inevestments in Kenya
Authors: Mmeri Ambetsa Nelson , Ongeri B. Onkoba , Ndolo David Katuta 
Published: July 2023

Domestic private investment serves as a prerequisite for the development and modernization of any economy. In Kenya, macroeconomic and political uncertainties play a significant role in influencing private domestic investments. This is informed by the fact that these investments allow investors to fund ventures, which creates jobs and increase government revenues through taxation. Hence, it boosts the growth of the economy and improves the living standards of the people. However, private domestic investments are severely affected by both macroeconomic and political uncertainties about how the government formulates political, economic, and regulatory policies that affect the business climate. Investors are risk-averse; hence they base investment decisions on prevailing and future conditions of the business environment. This paper focuses on analyzing the effects of uncertainty on Kenya’s domestic private investments. The study estimated the Autoregressive-Distributed Lag (ARDL) bounds technique which captures both short and long-run dynamics of this relationship among the variables. Time series data from UNCTAD, the World Bank, and the Central Bank of Kenya for the period spanning 1980 to the year 2019 was used. The study results suggest that real GDP (RGDP) and real effective exchange rates (REER) have a significant and positive effect on private domestic investment (PDI). In contrast, inflation (INFL), Real interest rates (RINR), Political uncertainty (PRI), and WUIKEN (economic policy uncertainty and volatility in the stock markets) have a negative and significant effect on private domestic investments. Based on these results, the most significant factors affecting private domestic investments were found to be political uncertainty (PRI), real gross domestic product (RGDP), and WUIKEN (economic policy uncertainty and volatility in the stock markets). Effectively, the study recommends that the government should enact policies that increase the ease of doing business and reduce economic and political uncertainty, such as a reduction in the tax rate, stabilization of the exchange rate, and stable political environment to reduce investor uncertainty and skepticism and also to enhance their confidence.
Usage des TIC dans l’Approvisionnement de la Région du Haut-sassandra en Produits Carburants
Authors: Fulgence Konan Amani , Kouassi Évariste Tanou Yoboué , Aloko-N’Guessan Jérome 
Published: July 2023

En Côte d’Ivoire, les produits pétroliers convoyés et distribués aux populations dans la région du Haut-Sassandra sont issus des entités portuaires d’Abidjan. Depuis ces dernières décennies, les Technologies de l’Information et de la Communication (TIC) régulent les flux pétroliers acheminés aux usagers. Néanmoins, les actes traditionnels dans la satisfaction des utilisateurs des produits carburants peinent à connaitre une réelle amélioration. Cette étude se propose de montrer l’impact des TIC dans le processus d’acheminement de ces frets pétroliers d’Abidjan vers le Haut-Sassandra. Suite à la recherche documentaire, l’enquête de terrain est axée sur une série d’entretien avec des marketeurs, des pompistes, des transporteurs de camions citernes et des automobilistes. Ainsi, dans le processus de diffusion des produits carburants dans le Haut-Sassandra, les TIC permettent la disparition des barrières physiques et spatio-temporelles. Excepté le contact permanent entre les acteurs du réseau de distribution, la téléphonie mobile et le GPS sont indéniables pour anticiper d’éventuelles pénuries à la station-service. Cette présence régulière de produits carburants dans la région du Haut-Sassandra accroit ainsi les profits pécuniaires de ces promoteurs. Mais, malgré l’avènement des TIC dans le paysage ivoirien, les structures étatiques peinent à suivre et contrôler en temps réel les trafics pétroliers des entités vers les régions nationales.

In Côte d'Ivoire, the petroleum products transported and distributed to the populations in the Haut-Sassandra region come from the port entities of Abidjan. For the past few decades, Information and Communication Technologies (ICT) have been regulating the flow of oil products to users. Nevertheless, the traditional acts in the satisfaction of users of fuel products are struggling to make a real improvement. This study proposes to show the impact of ICT in the process of routing these oil freights from Abidjan to the Haut-Sassandra. Following the documentary research, the field survey is centered on a series of interviews with marketers, pumpers, tanker transporters and motorists. Thus, in the process of disseminating fuel products in the Haut-Sassandra, ICTs allow physical and spatio-temporal barriers to disappear. Apart from the permanent contact between the actors of the distribution network, mobile telephony and GPS are undeniable for anticipating possible shortages at the service station. This regular presence of fuel products in the Haut-Sassandra region thus increases the financial profits of these promoters. However, despite the advent of ICTs in the Ivorian landscape, state structures are struggling to monitor and control in real time oil traffic from the entities to the national regions.