bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene signature from cutaneous autoimmune diseases provides potential immunotherapy-relevant biomarkers in melanoma
Authors: Chun Kyu-Hye , Park Ye-Chan , Hwang Nahee , Yoon Bo Kyung , Kim Jae-woo , Fang Sungsoon 
Published: September 2023

AbstractImmune checkpoint inhibitors (ICIs) are promising agents for treating melanoma. Given that autoimmune skin diseases exhibit hyper immune reaction, investigation of immune cells from autoimmune skin disease is crucial to validate the effectiveness of ICIs in melanoma treatment. We employed multipanel markers to predict the response to immune checkpoint inhibitors by characterizing the gene expression signatures of skin immune cells in systemic lupus erythematosus (SLE), atopic dermatitis (AD), and psoriasis (PS). By analyzing single-cell RNA sequencing data from each dataset, T cell gene signatures from autoimmune skin diseases exhibit a complex immune response in tumors that responded to immunotherapy. Based on that CD86 and CD80 provide essential costimulatory signals for T cell activation, we observed that interaction of CD86 signaling has been enhanced in the T cells of patients with SLE, AD, and PS. Our analysis revealed a common increase in CD86 signals from dendritic cells (DCs) to T cells in patients with SLE, AD, and PS, confirming that dendritic cells produce pro-inflammatory cytokines to activate T cells. Thus, we hypothesize that T cell gene signatures from autoimmune skin diseases exhibit a pro-inflammatory response and have the potential to predict cancer immunotherapy. Our study demonstrated that T cell gene signatures derived from inflammatory skin diseases, particularly SLE and PS, hold promise as potential biomarkers for predicting the response to immune checkpoint blockade therapy in patients with melanoma. Our data provide an understanding of the immune-related characteristics and differential gene expression patterns in autoimmune skin diseases, which may represent promising targets for melanoma immunotherapy.
Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs
Authors: Miura Marina , Miura Yutaka , Iwazu Yoshitaka , Mukai Hideyuki , Sugiura Takahiro , Suzuki Yuji , Kato Masami , Kano Mayumi , Nagata Daisuke , Shiizaki Kazuhiro , Kurosu Hiroshi , Kuro-o Makoto 
Published: September 2023

AbstractHyperphosphatemia is a major risk for poor prognosis in patients with end-stage renal disease. However, the molecular mechanism behind this link remains elusive. We and others have demonstrated that serum phosphorus levels correlate positively with circulating levels of calciprotein particles (CPPs). CPPs are colloidal mineral-protein complexes containing insoluble calcium-phosphate precipitates and have been reported to induce calcification in cultured vascular smooth muscle cells and inflammatory responses in cultured macrophages. Hence, we hypothesize that CPPs may be responsible for disorders associated with hyperphosphatemia. Using hyperphosphatemic miniature pigs receiving hemodialysis, here we show that removal of CPPs from the blood with a newly developed CPP adsorption column improves survival and alleviates complications including coronary artery calcification, vascular endothelial dysfunction, metastatic pulmonary calcification, left ventricular hypertrophy, and chronic inflammation. The present study identifies CPPs as an effective therapeutic target and justifies clinical trials to determine whether the CPP adsorption column may be useful as a medical device for improving clinical outcomes of hemodialysis patients.
Efficacy of a synthetic peptide Chlamydia pecorum major outer membrane protein vaccine in a wild koala (Phascolarctos cinereus) population
Authors: Simpson Sarah J. , Higgins Damien P. , Timms Peter , Mella Valentina S. A. , Crowther Mathew S. , Fernandez Cristina M. , McArthur Clare , Phillips Samuel , Krockenberger Mark B. 
Published: September 2023

AbstractChlamydiosis is a significant disease affecting Eastern Australian koala (Phascolarctos cinereus) populations, impacting individual animal welfare and fecundity and therefore influencing population dynamics. The aim of this study was to investigate the effect of a synthetic peptide vaccine based on 4 components of the Chlamydia pecorum major outer membrane protein (MOMP), over an 18-month period in a koala population severely impacted by chlamydiosis. Wild koalas were recruited into a vaccination or a placebo treatment group on a random allocation, then followed through a period of 18 months, with recapture at 6 monthly intervals. Vaccination did not alter clinical disease expression or chlamydial shedding from the ocular or urogenital sites. Vaccination did not stimulate a significant plasma anti-MOMP IgG response, when compared to the placebo group. There was no significant effect of vaccination on IFN-γ and IL-17A mRNA expression of peripheral blood lymphocytes when stimulated with rMOMP. We have demonstrated that a synthetic peptide vaccination against chlamydiosis is not an effective management tool in a koala population with a high prevalence of C. pecorum infection and related disease. The lack of antigenic response found in this study suggests that further research utilising a larger, full-length antigen is an avenue worth investigation if we are to consider vaccination as a part of a management strategy in diseased koala populations.
Confocal Raman imaging reveals the impact of retinoids on human breast cancer via monitoring the redox status of cytochrome c
Authors: Surmacki Jakub Maciej , Abramczyk Halina 
Published: September 2023

AbstractThis paper expands the current state of knowledge on impact of retinoids on redox status of cytochrome c in cancers. Little is known how the expression of cytochromes may influence the development of cancers. We studied the effect of the redox status of the central iron ion in heme of cytochrome c. We determined the redox status of the iron ion in cytochrome c in mitochondria, cytoplasm, lipid droplets, and endoplasmic reticulum of the human breast cancer cells by Raman imaging. We incubated human breast adenocarcinoma cells (SK-BR-3) with retinoic acid, retinol and retinyl ester (palmitate) at concentration of 50 μM for 24 h. We recorded the Raman spectra and images of human breast cancer in vitro SK-BR-3 cells receiving redox stimuli by retinoic acid, retinol and retinyl ester (palmitate). The paper provides evidence that retinoic acid and retinol are pivotally important for mitochondrial energy homeostasis by controlling the redox status of cytochrome c in the electron transport chain controlling oxidative phosphorylation and apoptosis. We discussed the role of retinoids in metabolism and signaling of cancer cells. The paper provides experimental support for theoretical hypothesis how retinoic acid/retinol catalyse resonance energy transfer reactions and controls the activation/inactivation cycle of protein kinase PKCδ.
Seasonality, food security, diet quality and nutritional status in urban poor adolescents in Malaysia
Authors: Tay Janice Ee Fang , Tung Serene En Hui , Kaur Satvinder , Gan Wan Ying , Che’Ya Nik Norasma , Tan Choon Hui 
Published: September 2023

AbstractSeasonality was shown to have an effect on food availability and accessibility, increasing the risk of food insecurity and causing poor diet quality and malnutrition. Therefore, this study aimed to determine seasonal effects on household food security status, diet quality, and nutritional status of urban poor adolescents in Malaysia. A cohort study was conducted among 164 adolescents aged 10–17 from 12 People Housing Programme in Kuala Lumpur, Malaysia during the Northeast (November 2021 till March 2022) and Southwest (June 2022 till September 2022) monsoon. Household food security status was measured using the 18-item USDA Household Food Security Survey Module. Dietary intake was determined using a two-days 24-h dietary recall and translated into Standardized Malaysian Healthy Eating Index (S-MHEI). Anthropometric and haemoglobin level measurements were performed to determine nutritional status. Seasonality was found to have a significant effect on overall diet quality (p = 0.021), food groups such as fish (p < 0.001), meat/poultry/eggs (p = 0.003), and legumes/nuts (p < 0.001), and fat nutrient (p = 0.037) as well as anaemia status (p = 0.020) after controlling the confounders. Although food security did not vary with seasons, seasonality affected the consumption of certain food groups as well as anaemia status for urban poor adolescents. Seasonally sensitive nutrition initiatives should be developed to ensure diet adherence to recommendations, ultimately enhancing the diet quality of urban poor adolescents.
Intravenous immunoglobulins improve skin fibrosis in experimental models of systemic sclerosis
Authors: Speca Silvia , Farhat Meryem-Maud , Jendoubi Manel , Guerrier Thomas , Sanges Sébastien , Staumont-Sallé Delphine , Hachulla Eric , Dubucquoi Sylvain , Sobanski Vincent , Collet Aurore , Launay David 
Published: September 2023

AbstractSystemic sclerosis (SSc) is the most severe systemic autoimmune disease with currently no cure. Intravenous immunoglobulins (IVIg) are an attractive candidate in this disease to counteract inflammation and fibrosis but data are scarce and conflicting. This study, assessed the effects of IVIg in a murine HOCl-induced model of SSc. We showed that IVIg prevented skin inflammation and fibrosis, by mitigating the immune cell infiltration (p = 0.04), proinflammatory cytokines gene overexpression (IL1β, p = 0.04; TNFα, p = 0.04; IL6, p = 0.05), skin and dermal thickening (p = 0.003 at d21 and p = 0.0003 at d42), the expression markers of fibrosis, such as αSMA (p = 0.031 for mRNA and p = 0.05 for protein), collagen (p = 0.05 for mRNA and p = 0.04 for protein, p = 0.05 for the hydroxyproline content) and fibronectin (p = 0.033 for mRNA). Moreover, IVIg prevented HOCl-induced alterations in splenic cell homeostasis. When administered in curative mode, despite their ability to reduce skin and dermal thickness (p < 0.0001 and p = 0.0002), IVIg showed partial or more mixed effects on skin inflammation and established fibrosis. These data favor further clinical trials in SSc patients on the potential efficiency of early and/or repeated IVIg administration.
The Influence of Hearing Loss on the Pupil Response to Degraded Speech
Authors: Zekveld Adriana A. , Pielage Hidde , Versfeld Niek J. , Kramer Sophia E. 
Published: September 2023

Purpose:
Current evidence regarding the influence of hearing loss on the pupil response elicited by speech perception is inconsistent. This might be partially due to confounding effects of age. This study aimed to compare pupil responses in age-matched groups of normal-hearing (NH) and hard of hearing (HH) listeners during listening to speech.

Method:

We tested the baseline pupil size and mean and peak pupil dilation response of 17 NH participants (
M
age
= 46 years; age range: 20–62 years) and 17 HH participants (
M
age
= 45 years; age range: 20–63 years) who were pairwise matched on age and educational level. Participants performed three speech perception tasks at a 50% intelligibility level: noise-vocoded speech and speech masked with either stationary noise or interfering speech. They also listened to speech presented in quiet.

Results:
Hearing loss was associated with poorer speech perception, except for noise-vocoded speech. In contrast to NH participants, performance of HH participants did not improve across trials for the interfering speech condition, and it decreased for speech in stationary noise. HH participants had a smaller mean pupil dilation in degraded speech conditions compared to NH participants, but not for speech in quiet. They also had a steeper decline in the baseline pupil size across trials. The baseline pupil size was smaller for noise-vocoded speech as compared to the other conditions. The normalized data showed an additional group effect on the baseline pupil response.

Conclusions:
Hearing loss is associated with a smaller pupil response and steeper decline in baseline pupil size during the perception of degraded speech. This suggests difficulties of the HH participants to sustain their effort investment and performance across the test session.
Speech-Language Pathologists' Perceptions of Language and Literacy Instruction for Pre-K Children With Developmental Language Disorder
Authors: Pfeiffer Danika L. , Feuerstein Julie , Landa Rebecca J. 
Published: September 2023

Purpose:
Speech-language pathologists (SLPs) have multiple roles and responsibilities related to language and literacy instruction in schools. The purpose of this exploratory, qualitative study was to analyze school-based SLPs' perceptions related to effective language and early literacy instruction for pre-K children with developmental language disorder (DLD). The goal of this study was to inform development of a new language and early literacy professional development program for inclusive pre-K teachers.

Method:
Eight school-based SLPs participated in a 1-hr virtual focus group conducted via Zoom recording technology. The researchers used a conventional content analysis approach to analyze the focus group data and identify themes from the discussion.

Results:
The researchers developed two themes: (a) SLPs identified repeated exposure to books, peer interaction, and teaching vocabulary with visual supports and props as key elements of language and literacy instruction that can be integrated into a variety of contexts, and (b) SLPs want more time with parents and teachers to support their book reading and model specific language strategies.

Conclusions:
SLPs identified several instructional practices inclusive pre-K teachers could be taught to use during professional development programs to support the emergent literacy development of children with DLD. They also discussed the need for ongoing collaboration between SLPs, caregivers, and teachers to maximize children's early language and literacy experiences. Future research should explore the impact of partnerships with caregivers and teachers on children's language and literacy outcomes.
An intermediate frequency reconfigurable bandpass noise‐shaping SAR ADC for IoT and mobile application
Authors: Kim Jonghyun , Oh Younggyun , Chae Hyungil 
Published: September 2023

AbstractThis letter proposes a reconfigurable bandpass noise‐shaping successive approximation register analog‐to‐digital converter (ADC) with a cascade of integrators with feedforward (CIFF) structure. Unlike conventional CIFF structures that use a passive feedforward path, the new design incorporates an amplifier within the filter, providing effective bandpass noise transfer function regardless of passband location, and facilitating the use of a unity gain 2‐input comparator for low noise and high stability. The loop filter includes amplification by a low power Gm‐R amplifier and two‐step charge sharing. The proposed ADC supports three different intermediate frequencies (IFs), and 12‐bit resolution is achieved for all IFs in a 28‐nm complementary metal‐oxide‐semiconductor (CMOS) process.
Chronic non-bacterial osteomyelitis (CNO) in childhood and adolescence – a disease with many faces
Authors: Steinborn Marc , Huf Veronika 
Published: September 2023

Background Chronic non-bacterial osteomyelitis (CNO) is a chronic inflammatory skeletal disease that affects particularly children and adolescents and is often diagnosed with a delay. With whole-body MRI, early diagnosis of this disease is possible in many cases. Since children and adolescents frequently present with non-specific complaints for outpatient radiological diagnosis, every radiologist should have basic knowledge of this complex clinical picture.
Materials In this review the basics and current findings regarding the disease are discussed. Unusual courses are also presented.
Results and Conclusion With knowledge of the radiographic and MR tomographic characteristics of the mostly multifocal bone lesions, the diagnosis of CNO can be reliably made in many cases. In particular, the early use of whole-body MRI plays an important role. Thus, therapeutic delays and resulting complications and the number of unnecessary biopsies for diagnosis can be reduced.
Keywords:
Plastic-strain-induced magnetocaloric effect of Pt3Fe ordered alloy
Authors: Kobayashi Satoru , Hotta Yuri 
Published: September 2023

We report a magnetocaloric effect of a plastically strained Pt3Fe antiferromagnet, in which ferromagnetism is induced due to the changes in the atomic arrangement around the {110} glide plane. The magnetic entropy change after the application of magnetic field increases with increasing applied plastic strain and shows a peak value of ∼0.1 J/K kg for an applied field of 50 kOe around the Néel temperature of 170 K. The magnetic entropy change can be due to the magnetization reversal of Fe magnetic moments in ferromagnetic domains formed around the {110} glide planes, and the peak temperature is influenced by the magnetic interaction between ferromagnetic domains and antiferromagnetic matrix. These observations suggest that a Pt3Fe chemically ordered alloy is a unique type of antiferromagnets in which the magnetocaloric effect can be induced and controlled by applied plastic strain.
Embedding stochastic differential equations into neural networks via dual processes
Authors: Sugishita Naoki , Ohkubo Jun 
Published: September 2023

Abstract
We propose a new approach to constructing a neural network for predicting expectations of stochastic differential equations. The proposed method does not need data sets of inputs and outputs; instead, the information obtained from the time-evolution equations, i.e. the corresponding dual process, is directly compared with the weights in the neural network. As a demonstration, we construct neural networks for the Ornstein–Uhlenbeck process and the noisy van der Pol system. The remarkable feature of learned networks with the proposed method is the accuracy of inputs near the origin. Hence, it would be possible to avoid the overfitting problem because the learned network does not depend on training data sets.
Transitions between quasi-stationary states in traffic systems: Cologne orbital motorways as an example
Authors: Wang Shanshan , Schreckenberg Michael , Guhr Thomas 
Published: September 2023

Abstract
Traffic systems can operate in different modes. In a previous work, we identified these modes as different quasi-stationary states in the correlation structure. Here, we analyze the transitions between such quasi-stationary states, i.e. how the system changes its operational mode. In the longer run this might be helpful to forecast the time evolution of correlation patterns in traffic. Taking Cologne orbital motorways as an example, we construct a state transition network for each quarter of 2015 and find a seasonal dependence for those quasi-stationary states in the traffic system. Using the PageRank algorithm, we identify and explore the dominant states which occur frequently within a moving time window of 60 days in 2015. To the best of our knowledge, this is the first study of this type for traffic systems.
The influence of creep on precision stability in precision instruments with assembly errors
Authors: Su Liang , Chen Xiao , Xiong Jian , Jin Xin , Zhang Zhijing 
Published: September 2023

Abstract
In the adhesive assembly of precision inertial instruments, it is easy for the center of mass to shift due to creep in the adhesive structure, resulting in a reduction in the accuracy of the instrument. In the presence of ambient temperature variations, these center of mass shifts can change further, causing variations in the accuracy of the instrument, that is, the accuracy stability problem. This paper investigates this accuracy stability problem. Firstly, numerical simulation modeling of an adhesive structure with assembly errors is carried out, then the center of mass displacement of the structure due to creep of the adhesive structure under different temperature loads is analyzed, and finally, experimental verification of the simulation results is carried out by developing a structural creep experimental device to verify the validity of the simulation results. This thesis provides a theoretical reference for the stability control of the accuracy of adhesive structures with assembly errors.
Design of magnetic flux leakage detector for mine wire rope
Authors: Ren Ming-Yue 
Published: September 2023

Abstract
At present, the online detection technology of wire rope damage in coal mine hoisting needs to be improved. Given the large number of detection elements and high detection cost in the wire rope detection device, the magnetic flux leakage detection device of the wire rope damage detection system is designed. The magnetic sensor is selected. At the same time, in order to improve the strength of the magnetic leakage field at the defect and reduce the number of magnetic sensors, a magnetic focusing device is designed. The finite element simulation shows that the magnetic focusing device can effectively improve the sensitivity of defect detection. The above research provides the basis for the design of steel wire rope damage detection systems and is of great significance to ensure the safe and efficient operation of mine hoisting equipment.
Research and Application of Calibration Device for Fire Emergency Lighting Detector
Authors: Deng Bin , Guan Ze-Xin , Ma Xue-Feng , Ru-Jia  , Wang Da-Long , Sun Xiao-Yan , Zhang Yuan-Yuan , Dong Guang-Kun , Wang Wei-Zhao 
Published: September 2023

Abstract
In order to solve the problem of quantitative traceability of detection devices for fire emergency lighting and evacuation indication systems. Method analysis and research were conducted on parameters such as emergency switching time, emergency working time, DC charging voltage, DC discharge voltage, DC charging current, DC discharge current, environmental test temperature, and environmental test humidity. We searched for appropriate calibration methods for the technical characteristics of each parameter and designed a set of calibration devices for fire emergency lighting detectors. The test results show that the technical indicators of the calibration device can meet the traceability requirements of the fire emergency lighting and evacuation indication system.
The Influence of Ball Milling Time and Sintering Temperature on the Structural and Capabilities of FeCoCrNiMn High-Entropy Alloy
Authors: Ma Yutian , Wang Zhenming , Tang Xingchang , Cheng Ganghu , Liu Yajun , Chen Kexuan , Zhang Zhijian , Lu Sujun , Sun Yuanjun , Liu Junzhao 
Published: September 2023

Abstract
This study reports the fabrication of FeCoCrNiMn high-entropy alloy using high-purity powders of Fe, Co, Cr, Ni, and Mn through the processes of mechanical alloying (MA) and spark plasma sintering (SPS). We systematically investigated the effects of different ball milling times (10 h, 20 h, 30 h, 40 h, 50 h) and sintering temperatures (700°C, 800°C, 900°C, 1000°C, 1100°C) on the structure and capabilities of the alloy. The findings indicate that the atomic proportion of Fe:Co:Cr:Ni:Mn approach 1:1:1:1:1. The distribution of all elements is basically uniform, but the Cr element is slightly biased in the structure after 40 h ball milling. The voids in the structure are gradually decreasing as temperatures rise. The matrix structure is mainly composed of a white FCC matrix phase and a gray Cr-rich σ phase. The alloy structure is the densest. It has the highest density of 7.060 g/cm3, the highest compressive strength of 1480 MPa, and a plastic deformation of 13% when the SPS temperature reaches 1000°C. The FeCoCrNiMn high-entropy alloy is prepared by a ball milling time of 40 h, and spark plasma sintering of 1000°C has the best comprehensive properties.