bluuebunny/crossref_metadata_2025_split huggingface dataset:
How strength of social ties modulates brain computations for Third-Party Punishment
Authors: Tang Zixuan , Qu Chen , Hu Yang , Benistant Julien , Moisan Frédéric , Derrington Edmund , Dreher Jean-Claude 
Published: February 2023

Abstract
Costly punishment of social norms transgressors by third-parties has been considered as a decisive stage in the evolution of human cooperation. An important facet of social relationship knowledge concerns the strength of the social ties between individuals, as measured by social distance. Yet, it is unclear how the enforcement of social norms is influenced by the social distance between a third-party and a norm violator at the behavioral and the brain system levels. Here, we investigated how social distance between punishers and norm-violators influences third-party punishment. Participants as third-party punished norm violators more severely as social distance between them increased. Using model-based fMRI, we disentangled key computations contributing to third-party punishment: inequity aversion, social distance with the norm violator and integration of the cost to punish with these signals. Inequity aversion increased activity in the anterior cingulate cortex and bilateral insula, and processing social distance engaged a bilateral fronto-parietal cortex brain network. These two brain signals and the cost to punish were integrated in a subjective value signal of sanctions that modulated activity in the ventromedial prefrontal cortex. Taken together, our results reveal the neurocomputational underpinnings of third-party punishment and how social distance modulates enforcement of social norms in humans.
Phase Change Materials for portable isothermal incubators as a solution to shorten effective analysis times in microbiological quality control of drinking water
Authors: Codony Francesc , Ventolà Lourdes , Sabaté Noemí , Dangla Carles 
Published: February 2023

Abstract
The microbiological quality control of water for human consumption of parameters relevant as E.coli and total coliforms does not start on the field despite the existence of test methods that could make it possible. One of the things that makes this difficult is the possibility of initiating an effective and reliable incubation at the sampling site. The appearance of isothermal media with phase change materials solves this limitation. When Phase change materials combine a relatively high melting heat with a suitable melting temperature adapted to the application temperature, they become excellent materials for thermal protection and for thermal energy storage. Starting the test at the same sampling point means that the effective times to obtain a result are shorter, improving water quality control. On the other hand, operationally, it also allows longer sampling routes. Both aspects are essential for managers responsible for controlling water quality for human consumption. In this work, the evidence that demonstrates the feasibility of this approach is presented.
Silicon uptake and accumulation as a nutrition in sugarcane for resistance against top borer Scirpophaga excerptalis Walker (Crambidae: Lepidoptera), its influence on larval mandibles and commercial cane traits
Authors: Priya Priya , Kumar Rajinder , Singh Dhanwinder 
Published: February 2023

Abstract
Top borer is a major pest of sugarcane which adversely affects the cane yield and sugar recovery. However, the mineral nutrient status of plants plays a crucial role in providing resistance to herbivores since they are quite sensitive to changes in host plant nutrition. In the current finding, the effect of various silicon sources (silicon material (SM) 50% @ 15, 12, 10 and 8 kg/acre, rice husk ash (RHA) @ 200 and 400 kg/acre and bagasse ash (BA) @ 200 and 400 kg/acre) at varied doses on the % incidence of top borer, cane yield and quality traits in sugarcane cultivar Co 238 was studied. The addition of silicon significantly (p ≤ 0.05) enhanced the silicon concentration in sugarcane stalk and soil (available form). The incidence of top borer (TB) was reduced significantly (p ≤ 0.05) up to a maximum of -37.62%. Cane yield and its attributes were significantly (p ≤ 0.05) increased with the application of silicon except for germination (p ≥ 0.05). Juice quality traits such as Brix (% soluble solids in juice), Sucrose (%), Commercial cane sugar (CCS q/acre) and Pol% cane were also improved significantly (p ≤ 0.05) in a tested cultivar with the addition of silicon. With the increase in the number of days after planting the stalk silicon content increased maximum up to 2.48% (T4) and the available soil silicon level decreased. The correlation analysis revealed that stalk silicon content has a significant (p ≤ 0.05) strong negative association (r= -0.959) with % infestation of TB and a strong positive (0.86 < r > 0.95) association with all cane yield and juice traits (brix, sucrose, CCS and pol% cane). The TB larvae feeding on silicon-rich tissues with deposited silicon as phytoliths (SEM images) have worn-out mandibles. Economic analysis showed that SM 50% @ 12 kg/acre was sufficient for reducing the infestation of TB up to 35.67% along with enhancing cane yield (50.82%) and CCS (56.73%). Hence, silicon could be used as a vital component for the integrated management of TB.
Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin
Authors: Zhou Jinfu , Liao Sining , Zhang Chenran , Luo Jinying , Li Guilin , Li Huangyuan 
Published: February 2023

Abstract
Background
Abnormal methylation of N6-methyladenosine (m6A) is reportedly associated with central nervous system disorders. However, the role of m6A mRNA methylation in unconjugated bilirubin (UCB) neurotoxicity needs to be further uncovered.
Methods
In this study, rat pheochromocytoma PC12 cells treated with UCB were used as in vitro models. After the PC12 cells treated with UCB (0, 12, 18, and 24 µM) for 24 hour, the total RNA m6A levels were measured using an m6A RNA methylation quantification kit. The expression of m6A demethylases and methyltransferases was detected by western blotting. We determined the m6A mRNA methylation profile in PC12 cells exposed to UCB (0, and 18 µM) for 24 hour using methylated RNA immunoprecipitation sequencing (MeRIP-seq).
Results
Compared with the control group, UCB (18 and 24 µM) treatment decreased the expression of the m6A demethylase ALKBH5 and increased the expression of the methyltransferases METTL3 and METTL14, which resulted in an increase in the total m6A levels in PC12 cells. Furthermore, 1533 m6A peaks were significantly elevated and 1331 peaks were reduced in the UCB (18 µM)-treated groups compared with those in the control group. Genes with differential m6A peaks were mainly enriched in protein processing in the endoplasmic reticulum, ubiquitin-mediated proteolysis, cell cycle, and endocytosis. Through combined analysis of the MeRIP-seq and RNA sequencing data, 129 genes with differentially methylated m6A peaks and differentially expressed mRNA levels were identified.
Conclusion
Our study suggests that the modulation of m6A methylation modifications plays a significant role in UCB neurotoxicity.
Structure Microscopy of an Atom in High Magneto-optical Medium Based on Transmission and Reflection Spectra
Authors: khan Aizaz , Ullah Syed Arif , Bacha Bakht Amin , Ullah Saeed , Akbar Jehan 
Published: February 2023

Abstract
A five level atomic medium driving by probe and standing waves control fields having dielectric function ϵr and permeability function µr is placed in a cavity of dielectric function ϵ1. The permittivity and permeability functions are directly related to the reflection and transmission spectra of the medium. The reflection and transmission spectra of the medium provide information about internal structure and properties of the atom. A central peak/depth is reported in the reflection and transmission spectra, which corresponds to the nuclear region of an atom. Around the central peak/depth regions, circular ring type patterns in the reflection and transmission spectra are reported. These ring type patterns exhibit atomic shells of the atoms. The theoretical investigation of internal structure microscopy of an atom have potential applications in nano-lithography and atom strapping. Our proposed model might be helpful for increasing the capability of optical microscopy and atoms imaging.
Fracture Resistance of Primary Molars After Pulpotomy Procedure Using Mineral Trioxide Aggregate or Biodentine
Authors: Topçuoğlu Gamze , Topçuoğlu Hüseyin Sinan 
Published: February 2023

Abstract
Objectives

The aim of this study was to examine the effect of different tricalcium silicate materials on the fracture resistance of pulpotomized primary molar teeth with class II mesio-occluso-distal cavities.

Materials and Methods

Seventy-five extracted mandibular primary molars were used in this study. The teeth were randomly divided into 5 groups (n = 15 for each group). In group 1, the teeth were left unprepared and unfilled (negative control); in group 2, pulpotomy cavities were performed, but left unfilled (positive control); in Group 3, mineral trioxide aggregate (MTA) and glass ionomer cement (GIC) was applied; in Group 4, Biodentin and GIC; and in Group 5, zinc oxide eugenol paste and GIC was placed in the pulp chamber. Then, cavities were restored with composite filling material. The teeth in all groups were subjected to thermocycling for 5000 cycles at 5°C–55°C. Each specimen was then subjected to fracture testing using a universal testing machine. The force required to fracture each specimen was recorded, and the data were analyzed statistically.

Results

Fracture resistance values obtained were as follows: Group1 > Group 4 > Group 3 = Group 5 > Group 2, (p < 0.05). The most common type of fracture was restorable in all experimental groups (p < 0.05).

Conclusion

Biodentine can be used as a suitable base material against fracture in teeth undergoing pulpotomy.

Clinical Relevance

The type of the base material used during the pulpotomy procedure may affect the fracture resistance of primary molar teeth.
Comparison of standard T2-weighted turbo spin echo and volumetric interpolated breath-hold examination magnetic resonance imaging sequences in the assessment of articular process dysplasia in Pug dogs with thoracolumbar myelopathy
Authors: Gilbert Emma , Rose Jeremy , Arrol Lorna , Driver Colin J. 
Published: February 2023

Abstract
Background: Retrospective study to compare the classification, as normal, hypoplastic or aplastic, of thoracic (T10-T13) caudal articular process (CAP) morphology in Pug dogs with a thoracolumbar myelopathy as normal, hypoplastic or aplastic, between T2 weighted Turbo Spin Echo (T2W-TSE) and Volumetric Interpolated Breath-hold Examination (VIBE) Magnetic Resonance Imaging (MRI) sequences, in comparison to Computed Tomography (CT). We hypothesised a stronger agreement for VIBE in comparison to T2W-TSE.
Results: Diagnostic accuracy of T2W-TSE was inferior to VIBE for aplastic (60%, 95% CI 0.561 – 0.639) versus 78%, 95%CI 0.744 - 0.815) hypoplastic (44%, 95%CI 0.427 – 0.452 versus 62.5%, 95%CI 0.595 - 0.655) and normal CAP (70%, 95%CI 0.655 – 0.744 versus 87% 95%CI 0.848- 0.892). Superior accuracy of classification using VIBE versus T2W-TSE sequences using the McNemar Chi squared test was significant for aplastic (p= 0.0002) and normal CAP (p=0.004). VIBE sequences had a sensitivity of 96% and specificity of 75% and with T2W-TSE imaging sensitivity 81% and specificity of 75%.
Conclusion: Three-dimensionally reconstructable VIBE sequences were significantly more accurate than traditional T2W-TSE MRI sequences in classifying CAP morphology, which should reduce the need for CT for pre-operative assessment.
Segmental infralesional denervation potentials in sub-acute traumatic spinal cord injury
Authors: Berger MJ , Adewuyi Adenike , Doherty Christopher , Hanlan Amy , Morin Cynthia , O'Connor Russ , Sharma Radhika , Sproule Shannon , Swong Kevin , Wu Harvey , Franz Colin , Brown Erin 
Published: February 2023

Abstract
Study Design: Two-centre retrospective cohort study.
Objectives: We examined the health of the infralesional LMN in individuals with traumatic cervical SCI, using data derived from the clinical electrodiagnostic examination performed early after SCI.
Setting: Academic hospitals.
Methods: We assessed 66 limbs in 42 individuals (40 males, mean age = 43.6±17.2, mean duration from injury = 3.3±1.5 months, 25 with motor complete injuries). Analysis was stratified by injury level as 1) C4 and above, 2) C5 and 3) C6-7. EMG performed on representative muscles from C5-6, C6-7, C7-8 and C8-T1, were included in analysis. LMN abnormality was dichotomized as present (abnormal spontaneous activity) or absent. Data were pooled for the most caudal infralesional segment (C8-T1).
Results: A high frequency of denervation potentials was seen in all infralesional segments for all injury levels. The pooled frequency of denervation potentials at C8-T1 was 74.6% of limbs tested. There was also evidence of denervation potentials at the rostral border of the neurological level of injury, as high as 64.3% of C5-6 muscles for C5 injuries.
Conclusion: These data support a high prevalence of infralesional LMN abnormality following SCI, which has implications to candidacy, timing of the intervention and donor nerve options.
Is there a relation between stillbirth and low population vitamin D levels? -a binational follow-up study of vitamin D fortification
Authors: Lindqvist Pelle G , Gissler Mika , Essén Birgitta 
Published: February 2023

Abstract
Background
Stillbirth has been associated with low plasma vitamin D. Both Sweden and Finland have been characterized by a high proportion of low plasma vitamin D levels (< 50nmol/L). We aimed to access the odds of stillbirth in relation to changes in National vitamin D fortification.
Methods
All pregnancies in Finland between 1994 and 2021 (n = 1,569,739) and Sweden (n = 2,800,730) with live or stillbirth registered in the Medical Birth Registries. The mean incidences before and after changes in the vitamin D food fortification programs in Finland (2003 and 2009) and Sweden (2018) were compared with cross-tabulation with 95% confidence intervals.
Results
In Finland, there was a reduction of stillbirth rate was reduced from ~ 4.1/1000 before 2003, to 3.4/1000 2004–2009 (odds ratio [OR] 0.87, 95% CI 0.81–0.93) and 2.8/1000 after 2010 (OR 0.84, 95% CI 0.78–0.91). In Sweden, the stillbirth rate decreased from 3.9/1000 2008–2017 to 3.2/1000 after 2018 (OR 0.83, 95%CI 0.78–0.89). The dose-dependent difference in Finland in a large sample with correct temporal associations, when the level decreased in Finland, it was steady in Sweden, and vice versa), indicate that the effect may be due to vitamin D. The findings should be interpreted as observational and may not be causal.
Conclusion
Each increment of vitamin D fortification was associated with a ≈ 15% fewer stillbirths on a national level. If true, and fortification reach all, it might be a milestone in preventing stillbirth and reduce health inequalities.
Best practices for portfolio optimization by quantum computing, experimented on real quantum devices
Authors: Buonaiuto Giuseppe , Gargiulo Francesco , De Pietro Giuseppe , Esposito Massimo , Pota Marco 
Published: February 2023

Abstract
In finance, portfolio optimization aims at finding optimal investments maximizing a trade-off between return and risks, given some constraints. Classical formulations of this quadratic optimization problem have exact or heuristic solutions, but the complexity scales up as the market dimension increases. Recently, researchers are evaluating the possibility of facing the complexity scaling issue by employing quantum computing. In this paper, the problem is solved using the Variational Quantum Eigensolver (VQE), which in principle is very efficient. The main outcome of this work consists of the definition of the best hyperparameters to set, in order to perform Portfolio Optimization by VQE on real quantum computers. In particular, a quite general formulation of the constrained quadratic problem is considered, which is translated into Quadratic Unconstrained Binary Optimization by the binary encoding of variables and by including constraints in the objective function. This is converted into a set of quantum operators (Ising Hamiltonian), whose minimum eigenvalue is found by VQE and corresponds to the optimal solution. In this work, different hyperparameters of the procedure are analyzed, including different ansatzes and optimization methods by means of experiments on both simulators and real quantum computers. Experiments show that there is a strong dependence of solutions quality on the sufficiently sized quantum computer and correct hyperparameters, and with the best choices, the quantum algorithm run on real quantum devices reaches solutions very close to the exact one, with a strong convergence rate towards the classical solution, even without error-mitigation techniques. Moreover, results obtained on different real quantum devices, for a small-sized example, show the relation between the quality of the solution and the dimension of the quantum processor. Evidences allow concluding which are the best ways to solve real Portfolio Optimization problems by VQE on quantum devices, and confirm the possibility to solve them with higher efficiency, with respect to existing methods, as soon as the size of quantum hardware will be sufficiently high.
A Study on the Influencing Factors and Related Paths of Farmer’s Participation in Food Safety Governance—Based on DEMATEL- ISM-MICMAC Model
Authors: Xie Jie-Hui , Tian Fu-Jun , Li Xue-Yuan , Chen Yu-Qing , Li Shi-Yi 
Published: February 2023

Abstract
Farmers' participation in food safety governance is an important part of food safety social co-governance, and the accurate identification of its influencing factors and their related paths is of guiding significance to the scientific decision-making of food safety governance. The system of influencing factors of farmers' participation in food safety governance was constructed from four dimensions, and the influence network of each dimension was revealed by decision laboratory analysis (DEMATEL). The hierarchical structure and correlation path of influencing factors were determined by interpretive structural model (ISM), and the attributes of influencing factors were further classified by cross influence matrix multiplication (MICMAC). The results show that the influencing factors of farmers' participation in food safety governance can be divided into seven levels, among which the level of education and the status of village cadres are the fundamental characteristic factors. the degree of rural informatization, the intensity of government supervision, the promotion of village committees, the response of the government and the degree of disclosure of government information are the deep core factors, and risk cognition, political trust and family eating habits are special factors. Taking the importance and attribute status of farmers' participation in food safety governance into decision-making considerations is of great significance to improve the efficiency of food safety governance.
Curcumin- and Piperine-Loaded Fe 3 O 4 @SiO 2 Magnetic Nanoparticles: Synthesis, Characterization, and Comparison of the Effects on MCF-7 Breast Cancer Cell Line
Authors: Rezaeidian Jalal , Naseh Vahid , Entezari Maliheh , Ziyadi Hakimeh , Hashemi Mehrdad 
Published: February 2023

Abstract
Breast cancer is amongst the commonest cancers which can result in cancer death in women worldwide. The curcumin and piperine are both known as natural polyphenols that have anti-cancer effects. However, quick degradation and metabolism, low bioavailability, and short half-life are some serious issues with the use of curcumin and piperine. Thus, given the importance of magnetic nanoparticles (MNPs) in cancer treatment on the one hand and to overcome the above-mentioned issues on the other, curcumin and piperine were loaded on magnetic iron nanoparticles coated with silica (Fe3O4@SiO2). Curcumin-loaded Fe3O4@SiO2 nanoparticles (Fe3O4@SiO2-curcumine), piperine-loaded Fe3O4@SiO2 nanoparticles (Fe3O4@SiO2-piperine), and curcumin/piperine-loaded Fe3O4@SiO2 nanoparticles (Fe3O4@SiO2-curcumin/piperine) were prepared by co-participation method followed by drug functionalization. The analysis of prepared magnetic nanoparticles were performed by scanning electron microscopy (SEM), vibrating-sample magnetometer (VSM), Fourier transform infrared spectrometer (FT-IR), and x-ray powder diffraction (XRD). Analysis approved successful loading of drugs on Fe3O4@SiO2 core-shell nanoparticles as well as good magnetic properties of curcumin- and piperine-loaded nanoparticles. Toxic effects of novel synthesized MNPs were measured by MTT assay on MCF-7 cancer cell lines. The results of MTT assay showed that all drug-loaded nanoparticles have anticancer effects on MCF-7 breast cancer cells, but impact of Fe3O4@SiO2-curcumin/piperine magnetic nanoparticles are greater than Fe3O4@SiO2-curcumine and Fe3O4@SiO2-piperine with drugs used alone, approving the synergistic effect of these two drugs on MNPs. These results provide a new perspective for cancer treatment using curcumin and piperine together.
Bacterial cellulose produced by Medusomyces gisevii on glucose and sucrose: biosynthesis and structural properties
Authors: Digel Ilya , Akimbekov Nuraly , Rogachev Evgeniy , Pogorelova Natalia 
Published: February 2023

Abstract
In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM) and x-ray diffraction (XRD). Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10g∙L-1 after a 18–20 days incubation period. Glucose in general lead to a higher BC yield (173g∙L-1) compared to sucrose (163.5g∙L-1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.