bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut microbiota composition and gene expression changes induced in the Apis cerana exposed to acetamiprid and difenoconazole at environmentally realistic concentrations alone or combined
Authors: Han Wensu , Ye Zheyuan , Gu Yifan , Zhong Yihai , Gao Jinglin , Zhao Shan , Wang Shijie 
Published: May 2023

Apis cerana is an important pollinator of agricultural crops in China. In the agricultural environment, A. cerana may be exposed to acetamiprid (neonicotinoid insecticide) and difenoconazole (triazole fungicide), alone or in combination because they are commonly applied to various crops. At present, our understanding of the toxicological effects of acetamiprid and difenoconazole on honey bee gut microbiomes is limited. The primary objective of this study was to explore whether these two pesticides affect honey bees’ gut microbiota and to analyze the transcriptional effects of these two pesticides on honey bees’ head and gut. In this study, adults of A. cerana were exposed to acetamiprid and/or difenoconazole by contaminated syrup at field-realistic concentrations for 10 days. Results indicated that acetamiprid and/or difenoconazole chronic exposure did not affect honey bees’ survival and food consumption, whereas difenoconazole decreased the weight of honey bees. 16S rRNA sequencing suggested that difenoconazole and the mixture of difenoconazole and acetamiprid decreased the diversity index and shaped the composition of gut bacteria microbiota, whereas acetamiprid did not impact the gut bacterial community. The ITS sequence data showed that neither of the two pesticides affected the fungal community structure. Meanwhile, we also observed that acetamiprid or difenoconazole significantly altered the expression of genes related to detoxification and immunity in honey bees’ tissues. Furthermore, we observed that the adverse effect of the acetamiprid and difenoconazole mixture on honey bees’ health was greater than that of a single mixture. Taken together, our study demonstrates that acetamiprid and/or difenoconazole exposure at field-realistic concentrations induced changes to the honey bee gut microbiome and gene expression.
Sex and gender role differences on stress, depression, and anxiety symptoms in response to the COVID-19 pandemic over time
Authors: Arcand Maryse , Bilodeau-Houle Alexe , Juster Robert-Paul , Marin Marie-France 
Published: May 2023

IntroductionStress, depression, and anxiety symptoms have been reported during the pandemic, with important inter-individual differences. Past cross-sectional studies have found that sex and gender roles may contribute to the modulation of one's vulnerability to develop such symptoms. This longitudinal study aimed to examine the interaction of sex and psychological gender roles on stress, depression, and anxiety symptoms in adults during the COVID-19 pandemic.MethodsFollowing the confinement measures in March 2020 in Montreal, stress, depression, and anxiety symptoms were assessed every 3 months (from June 2020 to March 2021) with the Depression, Anxiety and Stress Scale among 103 females and 50 males. Femininity and masculinity scores were assessed with the Bem Sex Role Inventory before the pandemic and were added as predictors along with time, sex, and the interactions between these variables using linear mixed models.ResultsWe observed similar levels of depressive symptoms between males and females, but higher levels of stress and anxious symptoms in females. No effects of sex and gender roles on depressive symptoms were found. For stress and anxiety, an interaction between time, femininity, and sex was found. At the beginning of the pandemic, females with high femininity had more stress symptoms than males with high femininity, whereas females with low femininity had more anxiety symptoms 1 year after the confinement measures compared to males with low femininity.DiscussionThese findings suggest that sex differences and psychological gender roles contribute to heterogeneous patterns of stress and anxiety symptoms over time in response to the COVID-19 pandemic.
The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults
Authors: Amiri Ehsan , Sheikholeslami-Vatani Dariush 
Published: May 2023

BackgroundThe aim of this study was to evaluate the effect of resistance training (RT) with creatine monohydrate supplementation (CS) on serum levels of 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), glutathione peroxidase (GPX), and total antioxidant capacity (TAC) in older adults.ObjectivesThis study evaluated the effect of resistance training with creatine monohydrate supplementation on oxidative stress and antioxidant defense, muscle strength and quality of life in older adults.MethodsWe examined 45 non-athlete volunteer older men and women (mean, 68.1 ± 7.2  years old), were randomly selected and divided into three groups of 15: RT with creatine supplementation (RT + CS), RT with placebo (RT + P) and control group. RT protocol was performed for 10  weeks, three sessions per week. Creatine supplement was taken daily at a dose of 0.1 g/kg of body weight, while the placebo group consumed the same amount of starch. Fasting blood samples were taken before the start of program and at the end of the RT period.ResultsIn the training groups, after 10  weeks of RT, a significant decrease in MDA and 8 - OHDG as well as a significant increase in serum levels of GPX and TAC were observed (in all cases, p =  0.001). In addition, creatinine levels were enhanced in the RT + CS (p =  0.014). Training intervention also improved quality of life and muscle strength in the experimental groups (p =  0.001), although muscle strength changes were more visible in the RT + CS group than in the RT + P group (p &lt;  0/05).ConclusionRegular resistance training can be recommended as a very suitable non-pharmacological approach to strengthen the body’s antioxidant system, muscle strength and quality of life in older adults. There are no definite findings on the role of creatine on the antioxidant system and quality of life in older adults, but the use of this supplement in addition to RT can double the amount of strength gained from resistance training.
Instrumental activities of daily living trajectories and risk of mild cognitive impairment among Chinese older adults: results of the Chinese longitudinal healthy longevity survey, 2002–2018
Authors: Yang Jialu , Zhang Yangchang , Shen Shisi , Yu Han , Yang Luran , Zhao Yao , Xiong Yang , Su Jiayi , Wang Lianlian , Lei Xun 
Published: May 2023

BackgroundThe association between the instrumental activities of daily living (IADL) score and the risk of initial cognitive function impairment is inconclusive. We aimed to identify distinctive IADL trajectories and examine their relationship with the onset of mild cognitive impairment (MCI) among Chinese older people.MethodsThe study used six-wave longitudinal data from the Chinese Longitudinal Healthy Longevity Survey conducted between 2002 and 2018. It included a total of 11,044 Chinese people aged 65 years or older. A group-based trajectory model was used to identify distinctive trajectories of the IADL score, and the Cox proportional hazards model was used to explore the hazard ratio of various trajectories at the onset of MCI. Interaction analysis was used to analyze individual modification between the IADL trajectories and the onset of MCI. Finally, we adopted four types of sensitivity analysis to verify the robustness of the results.ResultsDuring a median follow-up of 16 years, the incidence of MCI was 6.29 cases per 1,000 person-years (95% confidence interval [CI] 5.92–6.68). Three distinct IADL trajectory groups were identified: a low-risk IADL group (41.4%), an IADL group with increasing risk (28.5%), and a high-risk IADL group (30.4%). Using the Cox proportional hazards model after adjusting for covariates, we found that compared with the low risk IADL group, the hazard ratio of the IADL group with increasing risk was 4.49 (95% CI = 3.82–5.28), whereas that of the high-risk IADL group was 2.52 (95% CI 2.08–3.05). Treating the IADL group with increasing risk as the reference, the hazard ratio for the high-risk IADL group was 0.56 (95% CI 0.48–0.66). Interaction analyses showed that age and residence were significant moderators (P for interaction &lt;0.05).ConclusionA group-based trajectory model was developed to classify older people into three distinct trajectory groups of the IADL score. The IADL group with increasing risk had a greater risk of MCI than the high-risk IADL group. In the IADL group with increasing risk, city residents of ≥80 years were the most likely to develop MCI.
The current issues and challenges in the management of floating knee injury: a retrospective study
Authors: Kenmegne Guy Romeo , Zou Chang , Lin Yixiang , Yin Yijie , Huang Shengbo , Fang Yue 
Published: May 2023

PurposeThe management of floating knee injuries is still controversial and challenging for trauma specialists. This study aims to evaluate the incidence of the floating knee in lower limb trauma, analyzing the challenges in its management, and factors affecting clinical outcomes.MethodsIn this mono-center retrospective study, 36 consecutive patients were included. All individuals were diagnosed with an ipsilateral fracture of the femur and tibia, managed surgically according to their fracture pattern (Fraser classification), and the severity of the injury. The timing for each operation was determined based on the general condition of the patient and the local physiological condition of soft tissues. The patients’ clinical outcomes were finally evaluated based on their Karlstrom and Olerud scores and were categorized as excellent, good, acceptable, fair, or poor.ResultsIn this study, the mean follow-up period was 51.39 ± 16.02 months (11–130 months). Incidence of the floating knee was 2.32% in all lower limb traumas. From this number, 16 patients suffered from floating knee injury in the left lower extremity, and 18 in the right lower limb, while in 2 patients the condition was bilateral. The most common injury mechanism was road traffic accidents, accounting for 28 (77.78%) cases. The outcome was as follows; Excellent to good results in 22 (61.11%) cases, acceptable results in 2 (5.56%) cases, and fair to poor results in 12 (33.33%) cases according to the Karlström–Olerud scoring system. The most frequent early complications were wound infection and deep venous thrombosis in 5 (13.88%) of the cases. The most common late complication was common peroneal nerve palsy recorded in 2 (5.56%) cases.ConclusionThe presence of important concomitant injuries to the floating knee together with poor soft tissue conditions constituted important factors influencing possible management options and may have led to poorer clinical outcomes.
Functional assessment using 3D movement analysis can better predict health-related quality of life outcomes in patients with adult spinal deformity: a machine learning approach
Authors: Mekhael Elio , El Rachkidi Rami , Saliby Renee Maria , Nassim Nabil , Semaan Karl , Massaad Abir , Karam Mohamad , Saade Maria , Ayoub Elma , Rteil Ali , Jaber Elena , Chaaya Celine , Abi Nahed Julien , Ghanem Ismat , Assi Ayman 
Published: May 2023

IntroductionAdult spinal deformity (ASD) is classically evaluated by health-related quality of life (HRQoL) questionnaires and static radiographic spino-pelvic and global alignment parameters. Recently, 3D movement analysis (3DMA) was used for functional assessment of ASD to objectively quantify patient's independence during daily life activities. The aim of this study was to determine the role of both static and functional assessments in the prediction of HRQoL outcomes using machine learning methods.MethodsASD patients and controls underwent full-body biplanar low-dose x-rays with 3D reconstruction of skeletal segment as well as 3DMA of gait and filled HRQoL questionnaires: SF-36 physical and mental components (PCS&amp;MCS), Oswestry Disability Index (ODI), Beck's Depression Inventory (BDI), and visual analog scale (VAS) for pain. A random forest machine learning (ML) model was used to predict HRQoL outcomes based on three simulations: (1) radiographic, (2) kinematic, (3) both radiographic and kinematic parameters. Accuracy of prediction and RMSE of the model were evaluated using 10-fold cross validation in each simulation and compared between simulations. The model was also used to investigate the possibility of predicting HRQoL outcomes in ASD after treatment.ResultsIn total, 173 primary ASD and 57 controls were enrolled; 30 ASD were followed-up after surgical or medical treatment. The first ML simulation had a median accuracy of 83.4%. The second simulation had a median accuracy of 84.7%. The third simulation had a median accuracy of 87%. Simulations 2 and 3 had comparable accuracies of prediction for all HRQoL outcomes and higher predictions compared to Simulation 1 (i.e., accuracy for PCS = 85 ± 5 vs. 88.4 ± 4 and 89.7% ± 4%, for MCS = 83.7 ± 8.3 vs. 86.3 ± 5.6 and 87.7% ± 6.8% for simulations 1, 2 and 3 resp., p &lt; 0.05). Similar results were reported when the 3 simulations were tested on ASD after treatment.DiscussionThis study showed that kinematic parameters can better predict HRQoL outcomes than stand-alone classical radiographic parameters, not only for physical but also for mental scores. Moreover, 3DMA was shown to be a good predictive of HRQoL outcomes for ASD follow-up after medical or surgical treatment. Thus, the assessment of ASD patients should no longer rely on radiographs alone but on movement analysis as well.
Using Means of Electronic Educational Resources for Learning Lexicology and Phraseology
Authors: Hrona Nataliia , Vyshnyk Olena , Pinchuk Iryna 
Published: May 2023

The article revealed that electronic educational resources (EER) during the study of lexicology and phraseology provide forming communicative skills, enriching and expressing the vocabulary of education seekers.
The purpose of the paper is to analyze the features of using electronic educational resources during the study of lexicology and phraseology by education seekers.
In the course of the study, a set of research methods was used, which included theoretical (literature analysis, synthesis, generalization, comparison) and empirical (observation, conversations, etc.) methods.
The results. The development of lexicology and phraseology as sections of linguistic science is determined by analyzing and synthesizing scientific and methodological ideas.
It has been proven that the purpose of creating electronic educational resources is to ensure the modernization of the educational process. Thanks to the usage of EER, the content of lexical and phraseological material is updated, intensive exchange of information between students takes place. It is substantiated that in connection with the spread of COVID-19 and the introduction of martial law, education process in most educational institutions has moved to a distance learning based on information and communication technologies. Therefore, education seekers are actively involved in information resources, have the opportunity to select the necessary material, participate in virtual discussions, and communicate.
It has been found that EER give an opportunity to provide education seekers with the necessary information, increase the level and quality of educational services. The increase in the amount of information, the global processes of humanization, globalization, and integration objectively determine the modernization of the content of educational programs, and the renewal of forms, methods and means of learning during the study of vocabulary and phraseology.
Conclusions. It has been proven that there is a need to update the content of curricula and the content of courses in order to further develop communicative competence since the future personal success of students in adult life depends on the formation of skills to express themselves correctly, and clearly.
Modern Electronic Educational Technologies in the Process of E-Learning
Authors: Kovalenko Oksana , Hontarenko Iryna 
Published: May 2023

The purpose of the study is to focus attention on the positive aspects of using E-learning in contrast to the traditional format in a modern university, as well as on the need for effective management of E-learning in order to improve the quality of education.
Methodology. The following research methods were used to solve the assigned tasks: theoretical – analysis of scientific sources, pedagogical and teaching-methodical materials, comparison; empirical – generalization of pedagogical experience; a pedagogical experiment to check the effectiveness of organizing students' work using LMS Moodle platform.
Results. This study focuses on the positive aspects of using E-learning. Introducing E-learning into the educational process provides new opportunities, provides everyone with the necessary knowledge and develops digital literacy skills. The study analyses the current state of е-learning in higher education and summarizes some theoretical issues of using LMS Moodle, both positive and negative. It offers practical suggestions for the qualitative integration of E-learning into the teaching and learning process based on practical and good management of the E-learning process. The case of Simon Kuznets Kharkiv National University of Economics is used, which implemented the distance learning platform, a platform called “Personal Learning Systems” (PLS). A management system for electronic learning at the university was developed based on the modelling method, the primary purpose of which is to use modern electronic educational technologies in the educational process, to prepare a methodological base for electronic educational resources, and to improve electronic educational technologies in the format of electronic learning.
Conclusions. The E-learning management system “personal learning systems” (PLS) in the university is considered an information-management system whose primary purpose is the application of modern electronic educational technologies in the educational process, in the preparation of a methodological base of electronic educational resources, improvement of electronic educational technologies in a distance learning format.
A Sociological Perspective about Marutham Regional People
Authors: S Kumarasamy , M Kavitha 
Published: May 2023

When we closely approach the lifestyle of the people of the Sangam period, the people of that time have their own lifestyles and occupations according to the backgrounds of five landforms Kurinji, Mullai, Marutham, Neithal and Paalai. The lifestyle and culture of the people of these five lands have the common elements of the people of the Sangam period, but when we approach these subtly, it is possible to know that each land's people operate with their own unique lifestyle norms, social structure, and cultural elements. The people of Marutham land, who know the occupation of plowing, do not know occupations like robbery and murder that was followed by Paalai land people. The people of the Nellai land who caught fish in the sea do not know the professions like rice paddy and weeding. Each land people have their own unique land identity, occupation, lifestyle, worship, ritual, customs, food, dress, clothing, etc. The hypothesis of this article is to examine the life style of Marutham land people as described in Ettuthogai anthology take the way of life of the people of Marudham lands and describes about the high cultural thoughts of Tamil people.
TINJAUAN HAMBATAN SAMPING, KAPASITAS DAN TUNDAAN LALU LINTAS PADA SIMPANG TIDAK BERSINYAL DIKOTA MATARAM
Authors: ROHANI ROHANI , HASYIM HASYIM 
Published: May 2023

On several roads in the city of Mataram, such as the Dr. Wahidin road, there are many shops that do not have enough parking space, so many vehicles are parked on the shoulder of the road and even on the road. The presence of pedestrians crossing the road and the activity of vehicles entering/exiting the road affect the speed of traffic, and the capacity of the road so that at certain hours there are frequent traffic jams. This of course will have an impact on the delay at the intersection of Dr. Wahidin. As for the Caturwarga street, there are schools, hospitals and shops that do not have sufficient parking space, many vehicles that drop off and pick up passengers and vehicles that enter and leave the land use side of the road. Of course, this condition affects the smooth flow of traffic, so it has an impact on delays at the Catur Warga intersection. This study analyzes side resistance, capacity and delay at unsignalized intersections on Caturwarga and Dr. Wahidin roads. The total of this side resistance will be used to analyze how much influence it has on the delay using the 1997 MKJI method. The results of the analysis at the Catur Warga intersection have side friction, and the delays are 790.7 events/hour, 16.63 seconds/smp. Meanwhile, at the Dr. Wahidin intersection, the side friction and delays are 403.1 events/hour and 17.00 seconds/pcu, respectively. From the results of regression analysis, side barriers affect traffic delays by 89.7% and at Dr. Wahidin intersections by 79.7%. Partially at the Catur Warga intersection, the side friction variable that has the most influence on delays is Exit/Entrance Vehicles on the land use side of the road (EEV). On the Dr. Wahidin road, the side obstacle variable that has the most influence on delays is Pedestrians (PED).
TINJAUAN YURIDIS PERLINDUNGAN HUKUM PENGGUNA JASA TRANSPORTASI UMUM KHUSUSNYA TAKSI MENURUT UNDANG-UNDANG PERLINDUNGAN KONSUMEN
Authors: ARDIKA GEDE TUSAN , LOILEWEN ALINE FEBRIANY , TITAWATI TITIN 
Published: May 2023

According to the Consumer Protection Act " In this thesis consists of 2 (two) sub-problems namely, (1) What is the form of responsibility of the Driver and the Lombok Transportation Company Taxi if there is an accident on the passenger? (2) What is the legal remedy that can be taken by passengers at the Lombok Taxi Transportation Company for accidents suffered by passengers? To solve these sub-problems, the data collection method is used which is sourced from document studies and interviews.The results of this study indicate that: (1). The responsibility of the taxi company towards taxi service users starts from the transport of passengers to the agreed destination. Business operators are obliged to provide compensation for consumer losses due to accidents suffered by passengers. In carrying out its responsibilities, the Company and the driver have provided medical and maintenance costs. (2) What legal remedies are taken by passengers at the Lombok Taxi Transportation Company for accidents suffered by passengers, carried out through court (non litigation) and through court (litigation). Dispute resolution through out of court, carried out amicable settlement. If the peace route is not reached, then if one party and or the parties are not satisfied, they can file a lawsuit in the district court in the general court environment.