bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN DAN PENDAMPINGAN DALAM PEMBUATAN LAPORAN KEUANGAN USAHA KECIL MENENGAH AJIE FS
Authors: Verandita Clara 
Published: September 2023

Abstract Micro, Small and Medium Enterprises (MSMEs) are economic business activities carried out by individuals, households or business entities in accordance with applicable regulations. This study aims to discuss financial issues, especially regarding the preparation of financial reports based on SAK EMKM (Financial Accounting Standards for Micro, Small and Medium Entities) for individual companies or Micro, Small and Medium Enterprises (MSMEs). This Independent Study Report is written based on experience, research, and field conditions obtained during the Independent Study activity carried out at the Ajie FS Store Bandar Lampung for two months starting from February 11, 2021 to April 12, 2021. The problems faced by MSMEs are: there are some MSMEs who are not familiar with how to prepare financial reports in accordance with applicable regulations. Thus the author will help SMEs in solving the problem by helping the preparation of financial statements. Keywords: UMKM, Financial Reports, SAK EMKM.
MYANMAR MILITARY COUP ON 2021 : RESTORE THE GLORY ERA OF OPIUM
Authors: Mandagie Mike Natanael Norend 
Published: September 2023

Military coups are nothing new in the 21st century. Myanmar's military overthrew the existing democratic government in a coup d'état to gain power. Opium is the key behind the Myanmar military coup taking place in 2021. This article was written using both qualitative and quantitative methodologies. News in the mass media, both print and online, is also a source. The thirst for power has influenced the existing military so that actions without morals are committed. Many people consider that the coup carried out by the Myanmar military was an ordinary coup that was normalized because of the thirst for power. But behind that thirst for power lies a bigger plan for profit. The public needs to see the real reason behind the coup carried out by the Myanmar military in 2021 so that it can clearly and structuredly understand the coup that was carried out in 2021 which further put Aung San Suu Kyi under house arrest
Keywords: Opium, Government, Military, Power, Coup
ANALISIS PENGARUH TEMPERATUR AUSTENITE DAN MEDIA QUENCHING MATERIAL S45C DAN EMS45 TERHADAP KEKERASAN
Authors: Nugraha Aditya , Arifin Kurniawan Sindu , Setiawan Daniel Calvin 
Published: September 2023

Hardening adalah perlakuan panas dengan tujuan meningkatkan kekerasan pada baja. S45C merupakan material yang banyak digunakan sebagai part mesin yang membutuhkan proses harden. Pada beberapa kasus, material S45C tidak bisa menghasilkan kekerasan 50 HRC sesuai dengan katalog, maka diperlukan material pembanding sebagai material yang setara. Penelitian ini akan membandingkan material S45C dengan material EMS45 dilihat dari kekerasan yang dihasilkan sebagai opsi pengganti material S45C. Variasi temperatur austenite yang digunakan adalah 800° C , 825° C , 850° C , dan media quenching yang digunakan adalah oli, air-oli, dan air. Metode ANOVA digunakan untuk mengetahui pengaruh variasi temperatur dan media quenching. Material S45C, kekerasan 50 HRC didapatkan pada temperatur austenite 800° C, 825° C, dan 850° C dengan media quenching air. Pada material EMS45, kekerasan 50 HRC didapatkan dengan media quenching air, air-oli, dan oli pada temperatur austenite 850° C, dan 800° C dengan media quenching air-oli. Untuk material S45C, media quenching memiliki pengaruh 81%, dan temperatur austenite 4,2% terhadap hasil uji kekerasan sedangkan, material EMS45 media quenching memiliki pengaruh 83,9% dan temperature austenite 5,9% terhadap hasil uji kekerasan. Material EMS45 bisa digunakan sebagai material pengganti S45C.
Kata Kunci: harden, temperatur austenite, dan media quenching
PENGARUH SUDUT POTONG TERHADAP GETARAN PAHAT DAN KEKASARAN PERMUKAAN PADA PROSES BUBUT MILD STEEL BAJA ST37
Authors: Sadiana Riri , Ekawati Fatimah Dian , Surahto Aep , Fadilah Rizki Yasin 
Published: September 2023

Abstrak
Menentukan sudut potong pada proses bubut untuck menghasilkan kekasaran permukaan dan getaran pahat yang optimal pada proses bubut mild steel Baja ST 37. Tujuan penelitian ini adalah untuk mengetahui pengaturan sudut potong yang tepat pada proses bubut, sehingga dapat meminimumkan kekasaran permukaan dan getaran pada pahat dalam proses bubut mild steel Baja ST 37. Melalui metode eksperimen dengan sampel sebanyak 9 spesimen, dengan parameter kecepatan gerak makan 0.2 mm/rev, kedalaman pemotongan 1 mm, putaran mesin 800 rpm, dan variasi sudut potong 650, 750, dan 850 diperoleh hasil bahwa pengaturan sudut potong yang dipilih, meskipun semakin besar nilai sudut potong yang dipilih (untuk rentang 650 -850) maka akan semakin kecil nilai permukaan kekasaran yang diperoleh dari suatu proses bubut baja ST37 dengan parameter yang telah ditetapkan, pemilihan sudut potong 750 akan menghasilkan nilai rata-rata getaran terkecil, nilai kecepatan getaran yang diperoleh juga cenderung stabil.
Kata Kunci: Sudut Potong, Baja ST 37, Getaran

Abstract
The motivation for this study was to determine the importance of the cutting angle during turning for optimal surface roughness and tool vibration during turning of mild steel ST-37. ST-37 Tool Vibration During Light Turning. Through the experimental program of 9 samples, the feed rate is 0.2mm/rev, the cutting depth is 1mm, the motor speed is 800rpm, and the cutting angle is changed to 650, 750 and 850. The result is that the selected cutting angle setting, although the selected cutting the larger the angle value (range 650-850), the smaller the surface roughness value obtained by the ST37 steel turning process with predefined parameters, the choice of angle cutting 750 is the average value of the smallest vibration, and the obtained value of vibration speed n also tends to be stable.
Keywords: Angle of Cut, Steel ST 37, Vibration
A randomized control trial to assess optical coherence tomography parameters of the Xlimus drug-eluting stent: the XLIMIT trial
Authors: Testa Luca , Squillace Mattia , Ventrella Nicoletta , Moreno Raul , Jiménez-Valero Santiago , Serra Antoni , Gomez Hospital Joan Antoni , Bellamoli Michele , Popolo Rubbio Antonio , Bedogni Francesco 
Published: September 2023

BackgroundThird generation drug-eluting stents (DES) potentially offer better technical performance and reduced neointimal proliferation than previous generation DES. The XLIMIT non-inferiority trial evaluated the performance of the Xlimus (a novel sirolimus-eluting coronary stent system) in terms of endothelialization and tissue healing compared to the bioresorbable polymer Synergy DES.MethodsA total of 177 patients undergoing percutaneous coronary intervention (PCI) were randomized in a 2:1 ratio (2 Xlimus: 1 Synergy). The primary endpoints, defined as the in-stent neointimal volume weighted by the sum of the lengths of the implanted stent (ISNV) and the in-stent neointimal percent volume obstruction (%VO) were evaluated at 6–9 months by means of optical coherence tomography (OCT). Additional OCT parameters as well as clinical endpoints were also collected.ResultsMost of the patients were males (77.4%), and the mean age was 64 years. One third of the population had stable angina/silent ischemia. A total of 300 stents (237 lesions) were analyzed: 198 (152 lesions) were in the Xlimus group, and 102 (85 lesions) in the Synergy group. The ISNV in the Xlimus group was 30.7 ± 24.5 mm3 while in the Synergy group it was 26.5 ± 26.7 mm3: the difference between the two means was 0.08 (−0, 04–0, 45), p = 0.018, thus meeting the non-inferiority hypothesis. The %VO was 16.3% ± 10.4% and 13.3% ± 10.8% in the Xlimus and Synergy groups, respectively: the difference between the two means was 3.0 (−0, 06–4, 2), (p = 0.01), thus meeting the non-inferiority hypothesis. No difference was found with respect to the secondary OCT endpoints as well as for clinical endpoints.ConclusionsThe study results confirm that the biological interaction of the Xlimus and Synergy DES with the coronary artery is comparable, and that translates in very reassuring OCT parameters at follow-up: as such, the Xlimus is non-inferior to the Synergy.Clinical Trial RegistrationClinicalTrials.gov, identifier (NCT03745053).
Visual analysis of lung neuroendocrine tumors based on CiteSpace knowledge graph
Authors: Guo Mingjie , Hu Shaowen , Xiao Yaifei , Cao Zhan , Huang Zhichao , Liu Yalong , An Xiaokang , Zhang Guoyu , Zheng Xianjie 
Published: September 2023

ObjectiveThe relevant literatures in the field of pulmonary neuroendocrine tumor were analyzed to understand the lineage, hot spots and development trends of research in this tumor.MethodThe Web of Science core collection was searched for English-language literature about neuroendocrine tumors of the lung published between 2000 and 2022. CiteSpace software was imported for visualization analysis of countries, institutions, co-cited authors and co-cited journals and sorting of high-frequency keywords, as well as co-cited references and keyword co-occurrence, clustering and bursting display.ResultsA total of 594 publications on neuroendocrine tumours of the lung were available, from 2000 to 2022, with an overall upward trend of annual publications in the literature. Authors or institutions from the United States, Italy, Japan and China were more active in this field, but there was little cooperation among the major countries. Co-cited references and keyword co-occurrence and cluster analysis showed that research on diagnostic instruments, pathogenesis, ectopic ACTH signs, staging and prognosis and treatment was a current research hotspot. The keyword bursts suggested that therapeutic approaches might be a key focus of future research into the field for pulmonary neuroendocrine tumors.ConclusionOver these 20 years, research related to neuroendocrine tumors of the lung has increased in fervour, with research on diagnostic instruments, pathogenesis, ectopic ACTH signs, staging and prognosis, and treatment being the main focus of research. Therapeutic treatments may be the future research trend in this field.
Case Report: Unedited allogeneic chimeric antigen receptor T cell bridging to conditioning-free hematopoietic stem cell transplantation for a child with refractory Burkitt lymphoma
Authors: Yang Xiaomin , Luo Chengjuan , Qian Juan , Huang Xiaohang , Zhang Jian , Wang Jianmin , Luo Changying , Qin Xia , Li Benshang , Chen Jing 
Published: September 2023

PurposeBurkitt lymphoma (BL) is the most common tumor of non-Hodgkin’s lymphoma (NHL) in children, accounting for about 40% of cases. Although different combined short-course chemotherapies have achieved a good effect, refractory/relapsed BL has a poor prognosis with cure rates less than 30%. Chimeric antigen receptor T cell (CAR-T) therapy has developed rapidly in recent years and achieved excellent results in acute lymphoblastic leukemia (ALL). However, in some cases, there is a failure to produce autologous CAR-T cells because of T-cell dysfunction. In such cases, allogeneic CAR-T therapy has to be considered.MethodsA 17-year-old boy with stage II BL did not respond to extensive chemotherapy and sequential autologous CAR-T therapy. Lentiviral vectors containing anti-CD20-BB-ζ (20CAR) and anti-CD22-BB-ζ (22CAR) transgenes were used to modify the T cells from an HLA-identical matched unrelated donor. Flow cytometry was used to assess the cytokine analyses and CAR-T cell persistence in peripheral blood, enumerated by qPCR as copies per ug DNA. Informed consent for autologous/allogeneic CAR-T therapy was obtained from the patient and his legal guardian.ResultsUnedited HLA-matched allogeneic CD20 and CD22 CAR-T cells were infused after lymphodepletion chemotherapy with cyclophosphamide and fludarabine. The patient experienced Grade IV cytokine release syndrome (CRS) and went into complete remission (CR) after anti-inflammatory treatment including tocilizumab. Because of persistent pancytopenia and full donor chimerism, the same donor’s conditioning-free peripheral blood stem cells were successfully transplanted 55 days post CAR-T. Neutrophils were engrafted at day +11 and platelets were rebuilt at day +47 without obvious acute graft-versus-host disease (GVHD), but there was mild chronic GVHD in the skin and eyes. Currently, active anti-rejection therapy is still underway.ConclusionUnedited HLA-matched allogeneic CAR-T cell therapy could be an innovative, effective, and safe treatment for children with refractory/relapse BL without obvious acute GVHD. Conditioning-free allogeneic hematopoietic stem cell transplantation (HSCT) from the same donor is feasible for a patient with full donor T-cell chimerism after allogeneic CAR-T. It cannot be ignored that close GVHD monitoring is needed post HSCT.
Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4
Authors: Cooray Samantha , Price-Kuehne Fiona , Hong Ying , Omoyinmi Ebun , Burleigh Alice , Gilmour Kimberly C. , Ahmad Bilal , Choi Sangdun , Bahar Mohammad W. , Torpiano Paul , Gagunashvili Andrey , Jensen Barbara , Bellos Evangelos , Sancho-Shimizu Vanessa , Herberg Jethro A. , Mankad Kshitij , Kumar Atul , Kaliakatsos Marios , Worth Austen J. J. , Eleftheriou Despina , Whittaker Elizabeth , Brogan Paul A. 
Published: September 2023

We describe a novel, severe autoinflammatory syndrome characterized by neuroinflammation, systemic autoinflammation, splenomegaly, and anemia (NASA) caused by bi-allelic mutations in IRAK4. IRAK-4 is a serine/threonine kinase with a pivotal role in innate immune signaling from toll-like receptors and production of pro-inflammatory cytokines. In humans, bi-allelic mutations in IRAK4 result in IRAK-4 deficiency and increased susceptibility to pyogenic bacterial infections, but autoinflammation has never been described. We describe 5 affected patients from 2 unrelated families with compound heterozygous mutations in IRAK4 (c.C877T (p.Q293*)/c.G958T (p.D320Y); and c.A86C (p.Q29P)/c.161 + 1G&gt;A) resulting in severe systemic autoinflammation, massive splenomegaly and severe transfusion dependent anemia and, in 3/5 cases, severe neuroinflammation and seizures. IRAK-4 protein expression was reduced in peripheral blood mononuclear cells (PBMC) in affected patients. Immunological analysis demonstrated elevated serum tumor necrosis factor (TNF), interleukin (IL) 1 beta (IL-1β), IL-6, IL-8, interferon α2a (IFN-α2a), and interferon β (IFN-β); and elevated cerebrospinal fluid (CSF) IL-6 without elevation of CSF IFN-α despite perturbed interferon gene signature. Mutations were located within the death domain (DD; p.Q29P and splice site mutation c.161 + 1G&gt;A) and kinase domain (p.Q293*/p.D320Y) of IRAK-4. Structure-based modeling of the DD mutation p.Q29P showed alteration in the alignment of a loop within the DD with loss of contact distance and hydrogen bond interactions with IRAK-1/2 within the myddosome complex. The kinase domain mutation p.D320Y was predicted to stabilize interactions within the kinase active site. While precise mechanisms of autoinflammation in NASA remain uncertain, we speculate that loss of negative regulation of IRAK-4 and IRAK-1; dysregulation of myddosome assembly and disassembly; or kinase active site instability may drive dysregulated IL-6 and TNF production. Blockade of IL-6 resulted in immediate and complete amelioration of systemic autoinflammation and anemia in all 5 patients treated; however, neuroinflammation has, so far proven recalcitrant to IL-6 blockade and the janus kinase (JAK) inhibitor baricitinib, likely due to lack of central nervous system penetration of both drugs. We therefore highlight that bi-allelic mutation in IRAK4 may be associated with a severe and complex autoinflammatory and neuroinflammatory phenotype that we have called NASA (neuroinflammation, autoinflammation, splenomegaly and anemia), in addition to immunodeficiency in humans.
Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis
Authors: Zhu Yi , Liu Yuezhu , Wu Lanping , Yang Qian 
Published: September 2023

Background: In recent years, there has been a notable surge in the interest surrounding biodegradable materials, particularly in the context of biomedical applications. This has led to a significant rise in the number of research studies focusing on the utilization of biodegradable magnesium-based materials in the field of biomedicine. However, a dearth of comprehensive assessment exists regarding the body of research concerning biodegradable biomedical magnesium-based materials. In this study, a bibliometric approach was used to illustrate the current state of research and global trends pertaining to biodegradable magnesium-based materials for biomedical applications.Methods: We conducted a search of the Web of Science core collection database for the past decade (2013–2022). VOSviewer software and the bibliometric online analysis platform were employed for bibliometric analysis and visualization.Results: Correspondingly, 1267 documents were retrieved. We discovered that the number of papers in the field of degradable biomedical magnesium-based materials research has increased annually. In addition, China and the Chinese Academy of Sciences have published the largest number of papers in the field of biodegradable biomedical magnesium-based materials. Papers related to biodegradable magnesium-based materials for biomedical use were mainly published in acta biomaterialia, materials science and engineering c-materials for biological applications and materials journals. Keyword co-occurrence analysis showed that “corrosion"and “mechanical-properties” appear more frequently. The top 10 common keywords include corrosion, mechanical-properties, microstructure, biocompatibility, behavior, magnesium, magnesium alloys, degradation magnesium alloy, in vitro.Conclusion: Research on biodegradable magnesium-based materials for biomedical use continues to increase steadily. China maintains a leading position in the world, and the Chinese Academy of Sciences represents a notable contribution to the research of biodegradable magnesium-based materials for biomedical use. Subsequently, “corrosion” and “mechanical-properties” were identified as the current research hotspots in the area of biodegradable biomedical magnesium-based materials.
Feasibility of the preparation of cochleate suspensions from naturally derived phosphatidylserines
Authors: Kristensen Søren , Hassan Khadeija , Andersen Nadia Skarnager , Steiniger Frank , Kuntsche Judith 
Published: September 2023

IntroductionCochleates are cylindrical particles composed of dehydrated phospholipid bilayers. They are typically prepared by addition of calcium ions to vesicles composed of negatively charged phospholipids such as phosphatidylserines (PS). Due to their high physical and chemical stability, they provide an interesting alternative over other lipid-based drug formulations for example to improve oral bioavailability or to obtain a parenteral sustained-release formulation.MethodsIn the present study, the feasibility to prepare cochleate suspensions from soy lecithin-derived phosphatidylserines (SPS) was investigated and compared to the “gold standard” dioleoyl-phosphatidylserine (DOPS) cochleates. The SPS lipids covered a large range of purities between 53 and &gt;96% and computer-controlled mixing was evaluated for the preparation of the cochleate suspensions. Electron microscopic investigations were combined with small-angle x-ray diffraction (SAXD) and Laurdan generalized polarization (GP) analysis to characterize particle structure and lipid organization.ResultsDespite some differences in particle morphology, cochleate suspensions with similar internal lipid structure as DOPS cochleates could be prepared from SPS with high headgroup purity (≥96%). Suspensions prepared from SPS with lower purity still revealed a remarkably high degree of lipid dehydration and well-organized lamellar structure. However, the particle shape was less defined, and the typical cochleate cylinders could only be detected in suspensions prepared with higher amount of calcium ions. Finally, the study proves the feasibility to prepare suspensions of cochleates or cochleate-like particles directly from a calcium salt of soy-PS by dialysis.
Different responses of soil fungal and bacterial communities to nitrogen addition in a forest grassland ecotone
Authors: Li Daiyan , Meng Meng , Ren Baihui , Ma Xinwei , Bai Long , Li Jiahuan , Bai Guohua , Yao Fengjun , Tan Chunming 
Published: September 2023

IntroductionContinuous nitrogen deposition increases the nitrogen content of terrestrial ecosystem and affects the geochemical cycle of soil nitrogen. Forest-grassland ecotone is the interface area of forest and grassland and is sensitive to global climate change. However, the structure composition and diversity of soil microbial communities and their relationship with soil environmental factors at increasing nitrogen deposition have not been sufficiently studied in forest-grassland ecotone.MethodsIn this study, experiments were carried out with four nitrogen addition treatments (0 kgN·hm−2·a−1, 10 kgN·hm−2·a−1, 20 kgN·hm−2·a−1 and 40 kgN·hm−2·a−1) to simulate nitrogen deposition in a forest-grassland ecotone in northwest Liaoning Province, China. High-throughput sequencing and qPCR technologies were used to analyze the composition, structure, and diversity characteristics of the soil microbial communities under different levels of nitrogen addition.Results and discussionThe results showed that soil pH decreased significantly at increasing nitrogen concentrations, and the total nitrogen and ammonium nitrogen contents first increased and then decreased, which were significantly higher in the N10 treatment than in other treatments (N:0.32 ~ 0.48 g/kg; NH4+-N: 11.54 ~ 13 mg/kg). With the increase in nitrogen concentration, the net nitrogen mineralization, nitrification, and ammoniation rates decreased. The addition of nitrogen had no significant effect on the diversity and structure of the fungal community, while the diversity of the bacterial community decreased significantly at increasing nitrogen concentrations. Ascomycetes and Actinomycetes were the dominant fungal and bacterial phyla, respectively. The relative abundance of Ascomycetes was negatively correlated with total nitrogen content, while that of Actinomycetes was positively correlated with soil pH. The fungal community diversity was significantly negatively correlated with nitrate nitrogen, while the diversity of the bacterial community was significantly positively correlated with soil pH. No significant differences in the abundance of functional genes related to soil nitrogen transformations under the different treatments were observed. Overall, the distribution pattern and driving factors were different in soil microbial communities in a forest-grassland ecotone in northwest Liaoning. Our study enriches research content related to factors that affect the forest-grassland ecotone.