bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary refractory plasmablastic lymphoma: A precision oncology approach
Authors: Witte Hanno M. , Fähnrich Anke , Künstner Axel , Riedl Jörg , Fliedner Stephanie M. J. , Reimer Niklas , Hertel Nadine , von Bubnoff Nikolas , Bernard Veronica , Merz Hartmut , Busch Hauke , Feller Alfred , Gebauer Niklas 
Published: February 2023

IntroductionHematologic malignancies are currently underrepresented in multidisciplinary molecular-tumor-boards (MTB). This study assesses the potential of precision-oncology in primary-refractory plasmablastic-lymphoma (prPBL), a highly lethal blood cancer.MethodsWe evaluated clinicopathological and molecular-genetic data of 14 clinically annotated prPBL-patients from initial diagnosis. For this proof-of-concept study, we employed our certified institutional MTB-pipeline (University-Cancer-Center-Schleswig-Holstein, UCCSH) to annotate a comprehensive dataset within the scope of a virtual MTB-setting, ultimately recommending molecularly stratified therapies. Evidence-levels for MTB-recommendations were defined in accordance with the NCT/DKTK and ESCAT criteria.ResultsMedian age in the cohort was 76.5 years (range 56-91), 78.6% of patients were male, 50% were HIV-positive and clinical outcome was dismal. Comprehensive genomic/transcriptomic analysis revealed potential recommendations of a molecularly stratified treatment option with evidence-levels according to NCT/DKTK of at least m2B/ESCAT of at least IIIA were detected for all 14 prPBL-cases. In addition, immunohistochemical-assessment (CD19/CD30/CD38/CD79B) revealed targeted treatment-recommendations in all 14 cases. Genetic alterations were classified by treatment-baskets proposed by Horak et al. Hereby, we identified tyrosine-kinases (TK; n=4), PI3K-MTOR-AKT-pathway (PAM; n=3), cell-cycle-alterations (CC; n=2), RAF-MEK-ERK-cascade (RME; n=2), immune-evasion (IE; n=2), B-cell-targets (BCT; n=25) and others (OTH; n=4) for targeted treatment-recommendations. The minimum requirement for consideration of a drug within the scope of the study was FDA-fast-track development.DiscussionThe presented proof-of-concept study demonstrates the clinical potential of precision-oncology, even in prPBL-patients. Due to the aggressive course of the disease, there is an urgent medical-need for personalized treatment approaches, and this population should be considered for MTB inclusion at the earliest time.
The efficacy of Kangaroo-Mother care to the clinical outcomes of LBW and premature infants in the first 28 days: A meta-analysis of randomized clinical trials
Authors: Zhu Zhen , Wang Xinchen , Chen Wenzeng , Pei Shuping , Wang Qingmin , Guan Hailian , Zhu Guang 
Published: February 2023

ObjectiveThe objective of this study was to systematically determine the benefits of Kangaroo-Mother Care (KMC) on the clinical outcomes of low birthweight (LBW) and preterm infants.MethodsFor this study, the following databases were retrieved for articles published until November 2021: PubMed, Web of Science, EBSCO, and the Cochrane library. The primary clinical outcome was mortality between enrollment and 28 days. The secondary clinical outcomes were the mean duration of hospital stay, hypothermia, sepsis, exclusive breastfeeding at the end of the neonatal period, and exclusive breastfeeding at discharge.ResultsWe conducted a meta-analysis, which included 17 RCTs, involving overall 17,668 participants. The results of this meta-analysis showed that KMC could reduce the primary clinical outcome of mortality between enrollment and 28 days (RR: 0.80, 95% Cl: 0.71–0.91, p &lt; 0.01). For the secondary clinical outcomes, KMC had a varying degree of benefits on the mean duration of hospital stay (SMD: −0.96, 95% Cl: −1.02–0.90, p &lt; 0.001), hypothermia (RR: 0.45, 95% Cl: 0.27–0.75, p &lt; 0.01), and sepsis (RR: 0.79, 95% Cl: 0.70–0.89, p &lt; 0.001). The exclusive breastfeeding at the end of the neonatal period and exclusive breastfeeding at discharge of KMC had benefits, which was not statistically different though (OR: 2.16, 95% Cl: 0.55–8.41, p = 0.27; OR: 1.16, 95% Cl: 0.82–1.64, p = 0.39, respectively).ConclusionsKMC was decreased mortality in LBW and premature infants between enrollment and 28 days. In addition, KMC also had a favorable effectiveness on the secondary clinical outcomes, such as mean duration of hospital stay, hypothermia, sepsis. Moreover, KMC also had a slight effectiveness on exclusive breastfeeding at the end of the neonatal period and exclusive breastfeeding at discharge.
Mining towns and migration: Comparing three South African cases
Authors: Pretorius Anmar , Blaauw Derick 
Published: February 2023

IntroductionThe South African economy has a long history of mining exploration. The first mining operations were recorded in 1852. Literature has expressed the need to continue exploring the implications of internal and cross-border in-migration on the labor market of destination areas. This paper investigates migration patterns in South Africa by focusing on three mining towns (Postmasburg, Rustenburg and Emalahleni) in three different provinces.MethodsThis paper utilizes survey data from primary sources to investigate the potential link between migration patterns and mining output. The surveys formed part of an interdisciplinary research project under the auspices of the Center of Development Studies (CDS) at the University of the Free State.Results and discussionPostmasburg is the only mining town that experienced recent periods of expansion. This is reflected in the significant increase in the number of migrants moving to Postmasburg during 2011 and 2012, and the shorter average length of stay of migrants in Postmasburg (7.2 years compared to 9.8 years in Emalahleni and 11.0 in Rustenburg). The results resonate with the neo-classical notion of self-interest among younger people as a motivating factor for migration. Migrants in our samples were significantly younger than the locally-born respondents and display higher levels of education. Empirical results confirm this positive return on increased education levels with a positive and highly statistically significant return to every additional year of formal education. In all three towns, the dummy variable included to represent a distinction between mineworkers and non-mineworkers was statically significant. This confirms the general perception that mineworkers in all these communities receive a premium in terms of their monthly earnings-even after controlling for different levels of education. As part of a future research agenda, the role of environmental factors as a driver of migration could also be investigated in depth in Southern Africa.
Association between evergrande FC's club debt and Chinese super league's profitability from 2014 to 2019
Authors: Liu Zeyong , Liu Yuqian ,   Agudamu, Bu Te , Matic Radenko , Corilic Dusan , Casaru Catalina , Zhang Yang 
Published: February 2023

PurposeThis study examined the role of Evergrande FC's club debt on the Chinese Super League (CSL)'s profitability from 2014 to 2019.MethodsWe extracted the financial statements of Evergrande FC and evaluated its correlation with the profitability of CSL and Evergrande Group, which serves as a direct indicator of commercial growth.ResultsThe association between Evergrande FC's net loss and gross debt and CSL's profitability is positive, strong (all correlation coefficients &gt; .89), and statistically significant (all p &lt; .05). The association between Evergrande FC's net asset value and CSL's profitability is negative, strong (correlation coefficient = −.97), and statistically significant (p &lt; .05).ConclusionThese data imply that there is a good likelihood of a causal relationship between the negative club returns generated by real estate investments and CSL's rapid commercial growth from 2014 to 2019. In essence, a dovish monetary-regulatory policy nexus during this period drove up the CSL premium. This business history from the sports industry is another illustration of how the modern coupling of economic leverage and regulatory policy could have asymmetric impacts on short-term market growth. Based on this debt-fueled business history, CSL should progress to a higher level of development in the future.
Relevance of force-velocity and change of direction assessments for the ranking position in elite junior tennis players
Authors: Volk Nicola Reiner , Vuong Jo-Lâm , Ferrauti Alexander 
Published: February 2023

PurposeThis study aimed to correlate sprint mechanical parameters (SMP) of a linear sprint (LS) and a tennis specific modified 505 (Tm505) change of direction (CoD) test obtained with a motorized resistance device (MRD) to the current tennis ranking position (RP).Methods107 male and 86 female elite junior tennis players nationally ranked in the German Tennis Federation between 10 and 18 years participated in the study. According to their age at peak height velocity (PHV), players were divided into pre-PHV, circa-PHV, and post-PHV groups. SMP were derived from instantaneous time-velocity data of two 20 m all-out LS measured with 333 Hz. Further, mean values from two Tm505 trials with constant 3 kg loading over acceleration-deceleration (1a) and reacceleration (1b) phases were measured with an MRD. SMP of LS and CoD measurements were partially correlated with the current RP in the overall national ranking by controlling for biological maturation.ResultsLow to moderate correlations (rs = −0.1 to −0.3) were found between SMP and the RP in all male and female age groups. Correlations of the CoD measurements were overall more pronounced, particularly in girls (rs = −0.44). All linear SMP, like maximal theoretical force (F0; N/kg), and maximal theoretical velocity (v0; m/s), maximal power (Pmax; W/kg), improved over maturation for both genders with Pmax being most important for sprint performance. Further, Pmax was shown to correlate with the girls ranking position (rs = −0.31). During the Tm505, matured players achieved significantly faster overall total and CoD times. Positioning of CoM before CoD enlarged over maturation and was found to correlate to the RP in both sexes. In addition, nearly all SMP significantly correlated to the primary performance outcomes in the Tm505 test in both genders (r = −0.3 to −0.6).ConclusionCoD performance has a moderate and higher impact on tennis performance compared to LS. CoD performance as well as Pmax achieved a higher relevance for the ranking position predominantly in girls compared to boys. Hence, particularly Pmax as well as the transfer to on-court CoD motor skills should be a central training goal in elite junior tennis players besides technical skills and should depend on maturation status and gender.
Comparing the predictive performance of different lymph node staging systems for postoperative overall survival in patients with ampullary carcinoma
Authors: Li Xun , Chen Lin , Li Junli 
Published: February 2023

AimThis study was to analyze and compare the predictive performance of the 7th and the 8th edition American Joint Committee on Cancer (AJCC) N staging system, lymph nodes ratio (LNR) and log odds of positive lymph node (LODDS) for the survival of patients with ampullary carcinomas (ACs).MethodThis retrospective cohort study included patients with primary ACs after surgery from the Surveillance, Epidemiology, and End Results (SEER) 2004–2015. Univariate and multivariate Cox proportional hazard models were used. The study population was divided into a training set and a testing set in a ratio of 7–3. The C-index and area under the curve (AUC) were used to compare the predictive performance of the four staging on overall survival (OS) in the training set and the testing set.ResultsA total of 7,480 patients with primary ACs (1,178 survived and 1,128 dead) were in this study. The average follow-up time was 41.1 months. N1 stage and N2 stage of the 8th edition AJCC N staging system, LNR staging (0–0.3), LNR (&gt;0.3), LODDS (−2.4 to −0.8) and LODDS (&gt;−0.8) were associated with OS in AC patients after adjusting for age, race, pT stage, tumor size, grade, radiation, and insurance. The C-index of the 7th AJCC N staging was significantly lower than the C-index of the 8th AJCC N staging in the training set [0.608 vs. 0.629, P &lt; 0.001] and testing set [0.635 vs. 0.658, P &lt; 0.001]. The C-index of the LODDS staging was significantly higher than the C-index of the 8th AJCC N staging in the training set [0.641 vs. 0.629, P = 0.034] and testing set [0.671 vs. 0.658, P = 0.034]. LODDS staging may be a potential predictor of OS at 6 months [AUC = 0.687], 12 months (AUC = 0.692), and 48 months (AUC = 0.709), and LNR staging (AUC = 0.655) may be a potential predictor of OS at 24 months in AC patients. The predictive ability of LNR staging and LODDS staging were also found in different subgroups.ConclusionThe LNR and LODDS staging systems' predictive performance for OS of AC patients were superior to the 8th edition AJCC N staging system, especially in patients ages ≥65 or with higher tumor grade (grade II and III). The LNR staging and the LODDS staging were potential predictors for 24-month OS, and 6, 12, 24 and 48-month OS, respectively.
Bundles reduce anastomosis leak in patients undergoing elective colorectal surgery. A propensity score-matched study
Authors: Baeza-Murcia M , Valero-Navarro G , Pellicer-Franco E , Soria-Aledo V , Mengual-Ballester M , Garcia-Marin J. A , Betoret-Benavente L , Aguayo-Albasini J. L 
Published: February 2023

Backgroundanastomosis leak still being a handicap in colorectal surgery. Bowel mechanical preparation and oral antibiotics are not a practice recommended in many clinical practice guides. The aim is to analyse the decrease in frequency and severity of postoperative complications, mainly related to anastomotic leak, after the establishment of a bundle.MethodsSingle-center, before-after study. A bundle was implemented to reduce anastomotic leaks and their consequences. The Bundle group were matched to Pre-bundle group by propensity score matching. Mechanical bowel preparation, oral and intravenous antibiotics, inflammatory markers measure and early diagnosis algorithm were included at the bundle.ResultsThe bundle group shown fewer complications, especially in Clavien Dindós Grade IV complications (2.3% vs. 6.2% p &lt; 0.01), as well as a lower rate of anastomotic leakage (15.5% vs. 2.2% p &lt; 0.01). A significant decrease in reinterventions, less intensive unit care admissions, a shorter hospital stay and fewer readmissions were also observed. In multivariate analysis, the application of a bundle was an anastomotic leakage protective factor (OR 0.121, p &gt; 0.05)ConclusionsThe implementation of our bundle in colorectal surgery which include oral antibiotics, mechanical bowel preparation and inflammatory markers, significantly reduces morbidity adjusted to severity of complications, the anastomotic leakage rate, hospital stay and readmissions.Register studyThe study has been registered at clinicaltrials.gov Code: nct04632446.
دراسة في شعر بني القبطرنة
Authors: د. بيداء عبد نجم  
Published: February 2023

الحمد لله رب العالمين والصلاة والسلام على أشرف خلق الله سيدنا محمد 6 وعلى آله الطيبين الطاهرين وأصحابه ومن تبعهم بإحسان إلى يوم الدين .
وبعد :
فإن شعراء بني القبطرنة بالإضافة إلى كونهم وزراء في الدولة الأندلسية فإن شعرهم يمثل نموذج الشعر الأندلسي في عصر الطوائف. تضمنت هذه الدراسة وصف القدرة البلاغية العالية في التصوير والإبداع لدى هؤلاء ، وتأثرهم البالغ بالطبيعة والحياة التي كانوا يعيشونها. وقد تبين من خلال الأمثلة الشعرية إنها كانت تصدر عن تجارب حقيقية مروا بها في حياتهم. بالإضافة إلى ذلك تم دراسة الجانب الفني لشعرهم من خلال الاستعارة والتشبيه والكناية ، وتبين إن معظم شعرهم جاء سهلاً واضحاً لا غرابة فيه و لا تعقيد. حقق هؤلاء الشعراء قدرًا ملحوظًا من العمق في المعنى والبراعة في التصوير, فصوروا الخواطر النفسية والتأملات الفكرية بحكمة مما يُعد مجالا للإبداع في الشعر الأندلسي. عالج شعراء بني القبطرنة مختلف الموضوعات والأغراض الشعرية, وإن تميزت بعض الأغراض باهتمام أكثر من غيرها كالمدح والرثاء ، كما إنهم عالجوا طبيعة الحياة السياسية والتغيّرات الاجتماعية في الأندلس. ومن الجدير بالذكر أن شعر هؤلاء لم يتم تناوله في الدراسات الحديثة ولم يحظى كثيرا باهتمام الباحثين على المستوى الاكاديمي.
أثر إنموذج تراجيست في تحصيل قواعد اللغة العربية لدى طالبات الصف الأول المتوسط
Authors: نبيل إبراهيم جويريد  
Published: February 2023

يرمي البحث الحالي إلى تعرّف (أثر إنموذج تراجيست في تحصيل قواعد اللغة العربية لدى طالبات الصف الأول المتوسط ).
يتحدد البحث الحالي بعينة من طالبات الصف الاول المتوسط في المدارس المتوسطة والثانوية النهارية التابعة للمديرية العامة لتربية الرصافة / الثانية في محافظة بغداد، وموضوعات كتاب مادة قواعد اللغة العربية المقرر تدريسه لطالبات الصف الاول المتوسط في العراق للفصل الدراسي الاول للعام 2012-2013م.
اتّبع الباحث التصميم التجريبي ذا الضبط الجزئي تصميماً للبحث، وتألف مجتمع البحث من المدارس النهارية الثانوية والمتوسطة للبنات في المديرية العامة لتربية الرصافة / الثانية في بغداد. واختار الباحث قصدياً (ثانوية زهرة الهدى للبنات) التي تضم ثلاث شعب للصف الاول المتوسط، واختيرت عشوائياً شعبة (ب) لتمثل المجموعة التجريبية، في حين مثلت شعبة ( أ ) المجموعة الضابطة، وبلغت عينة البحث (88) طالبة بواقع (45) طالبة في المجموعة التجريبية، و(43) طالبة في المجموعة الضابطة.
أثر انموذج هيلدا تابا في تحصيل المفاهيم النحوية لدى تلاميذ المرحلة الابتدائية
Authors: م.م. ناديه ستار احمد  
Published: February 2023

اجريت هذه الدراسة في مدرسة عمان الابتدائية للبنين الواقعة في محافظة ديالى / بعقوبة واستهدفت معرفة اثر انموذج هيلدا تابا في تحصيل المفاهيم النحوية لدى تلامذة المرحلة الابتدائية .
تكونت عينة البحث من 54 تلميذ منهم( 27 ) تلميذ يدرس قواعد اللغة العربية بأنموذج هيلدا تابا و (27) تلميذ يدرس القواعد بالطريقة التقليدية كافأت الباحثة بين المجموعتين الضابطة والتجريبية في المتغيرات الاتية معدل درجات اللغة العربية للصف الرابع الابتدائي والتحصيل الدراسي للاب والام طبقت الباحثة التجربة في بداية العام الدراسي 2013-2014 واستمرت فصلا دراسيا كاملا وفي نهاية التجربة اجرت الباحثة اختبارا تحصيليا بعديا لكلا المجموعتين واظهرت النتائج وجود فرق ذي دلالة احصائية عند مستوى (0.05) ولمصلحة المجموعة التجريبية
دور التربية الإسلامية في رعاية المسنين دراسة وصفية تحليلية
Authors: أ. د. ناصر أحمد الخوالدة  
Published: February 2023

أن الركائز الأساسية للتربية الإسلامية هي الاهتمام بالمجتمع ككل والأخر من هذا هو الاهتمام بالوالدين لرؤيا بالوالدين إحسانا فأن الإسلام في مساراته وأسسه وجوهرة تهتم بهذه الشرعية من المجتمع وحده ركزت التربية الإسلامية في كل مقوماتها على هذه الشرعية المهمة في المجتمع العربي الإسلامي.
مشكلة الدراسة: تكمن مشكلة هذه الدراسة في الأهمية القصوى للاهتمام الشريعة اجتماعية كانت فاعلية يوم والآن أصبحت في حالة يرثى بها بالباحث أن يدرس هذه التربية وجوز التربية الإسلامية في رعاية المسنين.
تهدف هذه الدراسة إلى التعريف على مشكلة المسنين ودور التربية الإسلامية في رعاية هؤلاء الناس كشريحة اجتماعية لها سماتها وتركيب شخصياتها. وكذلك التعريف على أساليب الرعاية لهؤلاء المسنين.
Notice of Removal & Expression of Concern "Conventional Planar Chiral Structures to Realize Meta-Mirror with Polarization Conservation and Circular Dichroism"
Authors: Mitchell Arne , Johnson Emma , Liddell Elizabeth 
Published: February 2023

Compared to simple mirrors, meta-mirrors have the ability to conserve
the polarization of incident light in reflection. In previous decade, a
lot of meta-mirrors designed for various applications. In this paper, a
meta-mirror is demonstrated to simultaneously conserve the polarization
of incident light and the circular dichroism. A conventional chiral
structure is used to design the meta-mirror in microwave regime. The
chiral structure is C2-symmetric (breaking the rotational and mirror
symmetries) for chirality inclusion into the meta-mirror. The design
methodology uses the principle of febry-perot cavity which includes a
sandwiched geometry. The substrate used to design the structure is Roger
5880 (a low-loss material at higher frequency bands) with copper
material for chiral structure and back reflector. Moreover, the
meta-mirror shows the insensitivity towards incident angle of light.
This meta-mirror can have a lot of applications in optical setup,
communication, chiral absorption, spin-dependent reflections etc.
Loss Mask is all Your Need
Authors: Li HuaShun , Li JingZhao , Zhu Meng 
Published: February 2023

<p> In this paper, we propose an idea to improve various types of loss functions. It is different from the current idea of balancing the errors by increasing the number of input samples in each batch. We directly mask the top values of the error ranking to zero. During the error back-propagation, this means that the samples corresponding to that loss will not affect the parameter update of the network. In other words, even if a small number of samples are artificially mislabeled, it will not theoretically have much impact on the performance of the network. Instead, deliberately discarding anomalous losses will help smooth the training of the network. We conduct experiments on several regression and classification tasks, and the results show that the proposed method in this paper can effectively improve the expected performance of the network. </p>
OCDM-Based Multi-Numerology Communications for 6G
Authors: Savaux Vincent 
Published: February 2023

<p>This paper deals with the capability of the orthogonal chirp division multiplexing (OCDM) modulation scheme to cope with multi-numerology concept in the context of next generations of communications. The OCDM-based multi-numerology transceiver is introduced, and the inter-numerology interference (INI) is analytically derived. The case of filtered-OCDM is considered as well, allowing to both reduce the INI and to shape the power spectrum of the composite signal (i.e. the signal composed of unitary signals configured with different numerologies) according to strong constraints of low out-of-band emissions. The simulations results show the inherent robustness of OCDM against INI as the interference is spread over all subcarriers, whereas it is concentrated in particular subcarriers in OFDM. It results that the (filtered)-OCDM waveform largely outperforms the orthogonal frequency division multiplexing (OFDM) in term of bit error rate (BER) performance, without need for a guard-band between numerologies. </p>
Asymptomatic Azygos Vein Cement Embolism: A Potential Risk of Cement Injection via Cannulated Screw: A case report
Authors: Sapancı Mehmet , Eroğlu Ahmet , Mutlu Hakan , Atabey Cem 
Published: February 2023

Objective: Vertebroplasty is a method that stabilizes the fracture and relieves pain by injecting cement into the vertebral body that has lost its height for some reason. Cement injection can also be done through kyphoplasty and cannulated screw. During the injection, protrusion of the cementum from the corpus is a complication that must be avoided in this procedure. Cement extending out of the corpus may cause pulmonary cement embolism (PCE) via the azygos vein.
Case: A 76-year-old female patient was admitted to our clinic with the complaint of low back pain that had been going on for one year. The patient, who did not have motor or sensory deficits in the examination, described neurogenic claudication at 200 meters as well as sensitivity in the lumbar region. An osteoporotic collapse fracture in the L1 vertebra was detected in the patient's imaging. Transpedicular fixation, decompression, and cement-augmented pedicle screw were applied to the patient. After the operation, vena azygos cement embolism was detected in the thoracolumbar computed tomography (CT) scan conducted for follow-up. Although detailed tests were performed for pulmonary embolism (PCE), no findings were detected in the asymptomatic patient. During the follow-up examination after discharge, the patient did not report any respiratory complaints, pain in the lumbar region, or neurogenic claudication complaints.
Conclusion: PCE may develop after cement leakage into the azygos vein during cement injection. Although most PCEs remain asymptomatic, sometimes serious or even fatal sequelae have been reported. Cement overflows not reflected in fluoroscopy during the procedure can be detected by post-procedure imaging, and patients can be protected from serious complications.