bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of seismically‐isolated two‐block systems using a multi–rocking‐body dynamic model
Authors: Destro Bisol Giacomo , DeJong Matthew , Liberatore Domenico , Sorrentino Luigi 
Published: April 2023

AbstractA novel multibody rocking model is developed to investigate the dynamic response of two stacked rigid blocks placed on a linear base isolation device. The model is used to investigate the dynamic response of a realistic statue‐pedestal system subject to pulse‐like ground motions. The analysis shows that, in general, base isolation increases the safety level of the rocking system. However, for large period pulses or small size blocks, the isolator can amplify the ground motion, resulting in a lower minimum overturning acceleration than for the nonisolated system. Further, the amplification or shock spectrum of a linear mass‐dashpot‐spring oscillator, was found to be the reciprocal of the minimum nondimensional overturning acceleration of the investigated rocking system. Novel rocking spectra are obtained by normalizing the frequency of the pulse by the frequency of the isolator. The analysis also demonstrates how the dynamic response of the two stacked blocks is equivalent to that of a single‐block configuration coincident with the whole system assumed monolithic or the upper block alone, whichever is more slender.
A retrospective case–control study of gastrostomy use in children undergoing hematopoietic cell transplantation
Authors: Mellgren Karin , Nicolajsen Tom , Christoforaki Tania Panagiota , Juan Sara Marin , Mårtensson Thomas , Toporski Jacek , Casswall Thomas H. , Gustafsson Britt 
Published: April 2023

AbstractBackgroundMaintaining a good nutritional status during the hematopoietic cell transplantation (HCT) procedure is challenging in the pediatric population.MethodsIn a multicentric retrospective study, we compared the outcome of nutritional status and HCT‐related parameters in 227 pediatric patients during and after HCT between 2005 and 2015. 112 patients received a gastrostomy before the start of HCT (GS group), and 115 did not receive a gastrostomy (NGS). Data collection was performed at HCT, 3, 6, and 12 months post‐HCT.ResultsAt time point of HCT the Standard Deviation Score (SDS) of weight was 0.17 in the NGS group, and 0.71 in the GS group (p = .01) Patients in the NGS group lost more weight during the first 3 months after HCT than patients in the GS group. At 12 months, patients in the NGS remained at a lower weight, while patients in the GS group slightly increased their weight.There were no differences between the groups in the incidence of acute graft‐versus‐host‐disease (GvHD), overall survival, and non‐relapse mortality. However, the number of febrile episodes requiring intravenous treatment with antibiotics, was higher in the GS group as compared to the NGS group, during the first 3 months post‐HCT (p < .001).ConclusionsOur results indicate that gastrostomy can be utilized in children undergoing HCT without any negative effects on mortality. Therefore, the use of a gastrostomy appears to be a safe option to maintain a good nutritional status during the HCT procedure.
Comprehensive analysis of physiological and metabolomic responses to drought reveals specific modulation of acquired tolerance mechanisms in rice
Authors: Doddaraju Pushpa , Dharmappa Prathibha M. , Thiagarayaselvam Aarthy , Vijayaraghavareddy Preethi , Bheemanahalli Raju , Basavaraddi Priyanka A. , Malagondanahalli Mohan Kumar V. , Kambalimath Sumanth , Thulasiram Hirekodathakallu V. , Sreeman Sheshshayee M. 
Published: April 2023

AbstractMild stresses induce “acquired tolerance traits” (ATTs) that provide tolerance when stress becomes severe. Here, we identified the genetic variability in ATTs among a panel of rice germplasm accessions and demonstrated their relevance in protecting growth and productivity under water‐limited conditions. Diverse approaches, including physiological screens, association mapping and metabolomics, were adopted and revealed 43 significant marker‐trait associations. Nontargeted metabolomic profiling of contrasting genotypes revealed 26 “tolerance‐related‐induced” primary and secondary metabolites in the tolerant genotypes (AC‐39000 and AC‐39020) compared to the susceptible one (BPT‐5204) under water‐limited condition. Metabolites that help maintain cellular functions, especially Calvin cycle processes, significantly accumulated more in tolerant genotypes, which resulted in superior photosynthetic capacity and hence water use efficiency. Upregulation of the glutathione cycle intermediates explains the ROS homeostasis among the tolerant genotypes, maintaining spikelet fertility, and grain yield under stress. Bioinformatic dissection of a major effect quantitative trait locus on chromosome 8 revealed genes controlling metabolic pathways leading to the production of osmolites and antioxidants, such as GABA and raffinose. The study also led to the identification of specific trait donor genotypes that can be effectively used in translational crop improvement activities.
Metabolomic exhibits different profiles and potential biomarkers of Vitis spp. co‐cultivated with Fusarium oxysporum for short, medium, and long times
Authors: Costa Igor Rafael Sousa , Cavalcante Francisco Lucas Pacheco , Cavalcanti Fábio Rossi , de Freitas Fernandes Cleberson , Gomes‐Filho Enéas , Canuto Kirley Marques , de Carvalho Humberto Henrique 
Published: April 2023

AbstractDifferential rootstock tolerance to Fusarium spp. supports viticulture worldwide. However, how plants stand against the fungus still needs to be explored. We hypothesize it involves a differential metabolite modulation. Thus, we performed a gas chromatography coupled with mass spectrometry (GC–MS) analysis of Paulsen P1103 and BDMG573 rootstocks, co‐cultured with Fusarium oxysporum (FUS) for short, medium, and long time (0, 4, and 8 days after treatment [DAT]). In shoots, principal component analysis (PCA) showed a complete overlap between BDMG573 non‐co‐cultivated and FUS at 0 DAT, and P1103 treatments showed a slight overlap at both 4 and 8 DAT. In roots, PCA exhibited overlapping between BDMG573 treatments at 0 DAT, while P1103 treatments showed overlapping at 0 and 4 DAT. Further, there is a complete overlapping between BDMG573 and P1103 FUS profiles at 8 DAT. In shoots, 1,3‐dihydroxyacetone at 0 and 4 DAT and maltose at 4 and 8 DAT were biomarkers for BDMG573. For P1103, glyceric acid, proline, and sorbitol stood out at 0, 4, and 8 DAT, respectively. In BDMG573 roots, the biomarkers were β‐alanine at 0 DAT, cellobiose and sorbitol at both 4 and 8 DAT. While in P1103 roots, they were galactose at 0 and 4 DAT and 1,3‐dihydroxyacetone at 8 DAT. Overall, there is an increase in amino acids, glycolysis, and tricarboxylic acid components in tolerant Paulsen P1103 shoots. Thus, it provides a new perspective on the primary metabolism of grapevine rootstocks to F. oxysporum that may contribute to strategies for genotype tolerance and early disease identification.
Virus‐infected mast cells activate virus‐specific CD8+ T cells
Authors: Hackler Yana , Siebenhaar Frank , Maurer Marcus , Muñoz Melba 
Published: April 2023

AbstractEfficient anti‐viral responses of CD8+ T cells require signals that promote their effector cell differentiation, that are mainly provided by dendritic cells (DCs). Mast cells (MCs) are key drivers of DC maturation, but also influence their migration and antigen presenting properties and therefore indirectly mediate CD8+ T cell activation. MCs initiate innate immune responses at pathogen entry sites, promote the development of adaptive immune responses after infection, and release mediators including chemokines that recruit and activate immune cells including T cells during viral infections. However, whether MCs can directly activate virus‐specific CD8+ T cells remains largely unknown. Here, we used an in vitro viral infection model with lymphocytic choriomeningitis virus (LCMV)‐infected MCs or DCs co‐cultured with either LCMV‐specific CD8+ T cells or with WT (unspecific) CD8+ T cells. Similar to LCMV‐infected DCs, LCMV‐infected MCs clustered with virus‐specific CD8+ T cells and induced their activation and production of antiviral cytokines. In addition, the co‐stimulatory molecules CD86 and OX40L, but not CD80, were upregulated on MCs and an increased production of IL‐6 and type I interferons after LCMV infection was shown. Our findings suggest that MCs can promote CD8+ T cell activation during viral infections. MC‐mediated CD8+ T cell activation might be especially important within infected tissues where direct cellular interaction can take place. A better understanding of anti‐viral functions of MCs may help developing new strategies to better treat viral infections.
Evaluating the clinical utility of the systemic inflammatory response syndrome criteria in dogs and cats presenting to an emergency department
Authors: Spillane Amanda M. , Haraschak Jenica L. , Gephard Savanna E. , Nerderman Brooke E. , Fick Meghan E. , Reinhart Jennifer M. 
Published: April 2023

AbstractObjectiveEvaluate the clinical utility of the systemic inflammatory response syndrome (SIRS) criteria in dogs and cats presenting to an emergency room (ER).DesignProspective and retrospective observational study, conducted from November 2019 to February 2020.SettingSmall animal university teaching hospital.AnimalsProspective enrollment of 1143 dogs and 384 cats consecutively presenting to the ER. Retrospective enrollment of 65 healthy dogs and 57 healthy cats consecutively presenting to the primary care (PC) service.InterventionsNone.Measurements and Main ResultsPositive SIRS‐3 status was defined as meeting ≥2 of 3 (dogs) or 3 of 3 (cats) of the vital parameter SIRS criteria (temperature, heart rate, and respiratory rate). Positive SIRS‐4 status was defined as meeting ≥2 of 4 (dogs) and ≥3 of 4 (cats) of the vital parameter and CBC SIRS criteria. For each species, proportions of SIRS‐positive animals were compared between the ER and PC groups. Clinical outcomes were compared between SIRS‐positive and SIRS‐negative patients presenting to ER. The number of SIRS‐3‐positive dogs was statistically but not clinically different between the ER (69.9%) and PC (53.8%) groups (P = 0.009). Overall survival rate was 83% for SIRS‐3‐positive and 89% for SIRS‐3‐negative dogs presented to ER (P = 0.007). The number of SIRS‐3‐positive cats did not differ between ER and PC groups (P > 0.999). Overall survival rate was 61.1% for SIRS‐4‐positive and 86.8% for SIRS‐4‐negative cats presented to ER (P = 0.012).ConclusionsFulfilling the SIRS criteria is common in dogs and rare in cats regardless of presenting service. Meeting SIRS criteria on ER presentation carries a weak negative survival association in dogs and a moderate negative survival association in cats. This study demonstrates that the SIRS criteria have poor discriminatory ability to differentiate healthy from diseased patients and lacks a strong outcome correlation in small animal patients.
Tartaric acid induces toxicity in Madin–Darby canine kidney cells, but not human kidney‐2 cells in vitro, and is prevented by organic anion transporter inhibition and human OAT‐4 transfection
Authors: Coyne Sean R. , Landry Greg M. 
Published: April 2023

AbstractObjectivesTo evaluate the effect of tartaric acid (TTA) on Madin–Darby canine kidney (MDCK) cells compared to human kidney (HK)‐2 cells. Secondarily, to evaluate the effects of probenecid, an organic anion transporter (OAT)‐1 inhibitor, as well as human (h)OAT‐4 transfection into MDCK cells to prevent TTA‐induced cytotoxicity through decreasing accumulation via OAT‐1 uptake inhibition or increasing OAT‐4‐mediated TTA efflux.DesignSeventy‐two‐hour TTA concentration response and inhibitor studies in immortalized cell lines.SettingSchool of Pharmacy biomedical research laboratory and tissue culture facility.Animals/SamplesMDCK and HK‐2 immortalized cell lines.InterventionsBoth cell lines were treated with increasing concentrations of TTA for 72 hours. Additionally, MDCK cells were co‐incubated with TTA and increasing concentrations of probenecid or had been transfected with hOAT‐4 and subsequently treated with TTA for 72 hours.Measurements and Main ResultsMedia and samples were collected and lactate dehydrogenase (LDH) release was measured. LDH release was measured to assess TTA‐induced cytotoxicity after 72 hours. LDH was not significantly increased in the HK‐2 cells at any concentration but was significantly increased in the MDCK cells from 10 to 100 mM. LDH concentrations were significantly decreased (61%) in MDCK cells incubated with 50 mM TTA and probenecid when compared to TTA alone. hOAT‐4 MDCK cell transfection also significantly reduced LDH release (57%) when comparing the transfected MDCK cells to the nontransfected MDCK cells treated with 50 mM TTA.ConclusionsTTA is a species‐specific nephrotoxicant in dogs due to an interspecies difference in OAT‐4 expression. Inhibiting TTA uptake in MDCK cells in vitro using the OAT‐specific inhibitor, probenecid, prevents TTA‐induced cytotoxicity.
ACVECC‐Veterinary Committee on Trauma registry report 2017–2019
Authors: Hall Kelly E. , Rutten Jessica I. , Baird Taylor N. , Boller Manuel , Edwards Melissa , Hickey Mara , Raffe Marc R. 
Published: April 2023

AbstractObjectiveTo report summative data from the American College of Veterinary Emergency and Critical Care Veterinary Committee on Trauma (VetCOT) registry.DesignMulti‐institutional registry data report, April 1, 2017 to December 31, 2019.SettingVetCOT identified and verified Veterinary Trauma Centers (VTCs).AnimalsDogs and cats with evidence of trauma.InterventionsData were input to a web‐based data capture system (Research Electronic Data Capture) by data entry personnel trained in data software use and operational definitions of data variables. Data on demographics, trauma type, preadmission care, trauma severity assessment at presentation (modified Glasgow Coma Scale and Animal Trauma Triage score), key laboratory parameters, interventions, and case outcome were collected. Summary descriptive data for each species are reported.Measurements and Main ResultsThirty‐one VTCs contributed data from 20,842 canine and 4003 feline trauma cases during the 33‐month reporting period. Most cases presented directly to a VTC (82.1% dogs, 82.1% cats). Admission to hospital rates were slightly lower in dogs (27.8%) than cats (32.7%). Highest mortality rates by mechanism of injury in dogs were struck by vehicle (18.3%), ballistic injury (17.6%), injured inside vehicle (13.2%), nonpenetrating bite wound (10.2%), and choking/pulling injury (8.5%). Highest mortality rates by mechanism of injury in cats were struck by vehicle (43.3%), ejected from vehicle (33.3%), nonpenetrating bite wound (30.7%), ballistic injury (27.8%), and choking/pulling injury (25.0%). The proportion of animals surviving to discharge was 93.1% (dogs) and 82.5% (cats).ConclusionsThe VetCOT registry is a powerful resource for collection of a large dataset on trauma in dogs and cats seen at VTCs. Overall survival to discharge was high indicating low injury severity for most recorded cases. Further evaluation of data on subsets of injury types, patient assessment parameters, interventions, and associated outcome are warranted. Data from the registry can be leveraged to inform clinical trial design and justification for naturally occurring trauma as a translational model to improve veterinary and human trauma patient outcome.
Rapid resolution of hyperfibrinolysis in dogs with spontaneous hemoperitoneum following surgical control of hemorrhage
Authors: DeStefano Ian M. , Rozanski Elizabeth A. , Koethe Benjamin , de Laforcade Armelle M. 
Published: April 2023

AbstractObjectiveTo estimate the point prevalence and duration of hyperfibrinolysis (HF) in dogs undergoing surgical control of spontaneous hemoperitoneum (SHP).DesignProspective observational study.SettingSingle veterinary teaching hospital.AnimalsForty‐five client‐owned dogs with SHP were screened for HF. Eighteen HF dogs treated surgically were studied.InterventionsNone.Measurements and Main ResultsDogs with SHP and evidence of shock admitted for surgical control of hemorrhage were screened for HF. Blood samples were collected for PCV, total plasma protein, platelet count, and thromboelastography with 50 U/mL of tissue plasminogen activator at presentation and every 8 hours postoperatively until 72 hours, discharge, or death. HF was defined as a tissue plasminogen activator‐activated thromboelastography lysis percentage measured 30 minutes after maximum amplitude (LY30) of ≥20%. LY30 values were compared to a cohort of samples obtained from healthy dogs (n = 22). The point prevalence of HF in all dogs screened was 40% (18/45 dogs), and the mean LY30 at baseline for HF dogs was 48.9% (±24.2%), which was significantly higher than that of control dogs (4.8% ± 7.1%, P < 0.001) and non‐HF dogs (1.9% ± 5.7%, P < 0.001). In HF dogs, there was a significant decrease in LY30 between baseline and 8 hours (P < 0.0001) and between 8 and 16 hours (P = 0.035) but no significant change thereafter. LY30 at 8 hours (4%, range: 0%–23.4%) was not statistically different from control dogs (6.5%, range: 1.2%–32.8%, P = 0.664) suggesting early resolution of HF in this population. Only 2 of 18 dogs were persistently hyperfibrinolytic at 24 hours. Malignancy was diagnosed in 12 of 18 dogs (66.6%), while a benign etiology occurred in 6 of 18 dogs (33.3%). All HF dogs survived to discharge.ConclusionsHF occurs in some dogs with hypovolemic shock due to hemoperitoneum but resolves rapidly following surgical control of bleeding without antifibrinolytic medications. Routine postoperative use of antifibrinolytics in dogs with hemoperitoneum in dogs undergoing surgical control of bleeding may not be warranted.
Transport properties in the Horndeski holographic two-currents model
Authors: Zhang Dan , Fu Guoyang , Wang Xi-Jing , Pan Qiyuan , Wu Jian-Pin 
Published: April 2023

AbstractThe transport features of the holographic two-currents model are investigated in the Horndeski gravity framework. This system displays metallic or insulating characteristics depending on whether the Horndeski coupling parameter $$\gamma $$
γ
is negative or positive, but is unaffected by other system parameters such as the strength of the momentum dissipation $$\hat{k}$$

k
^

, the doping $$\chi $$
χ
and the coupling between two gauge fields $$\theta $$
θ
. Secondly, we demonstrate that the thermal conductivities are affected not only by the inherent properties of the black hole, but also by the model parameters. Furthermore, we are particularly interested in the Lorentz ratios’ properties. As expected, the Wiedemann–Franz (WF) law is violated, as it is in the majority of holographic systems. Particularly intriguing is the fact that several Lorentz ratio bounds reported in the typical axions model still remain true in our current theories. We would like to highlight out, however, that the lower bound for $$\hat{\bar{L}}_A$$

L

¯

^

A

is affected by the system parameters $$\chi $$
χ
, $$\theta $$
θ
and $$\gamma $$
γ
, which differs from the case of the typical axions model.
Cross-diffusion models in complex frameworks from microscopic to macroscopic
Authors: Burini D. , Chouhad N. 
Published: April 2023

This paper deals with the micro–macro derivation of models from the underlying description provided by methods of the kinetic theory for active particles. We consider the so-called exotic models according to the definition proposed in [ N. Bellomo, N. Outada, J. Soler, Y. Tao and M. Winkler, Chemotaxis and cross diffusion models in complex environments: Modeling towards a multiscale vision, Math. Models Methods Appl. Sci. 32 (2022) 713–792]. The first part of the presentation focuses on a survey and a critical analysis of some phenomenological models known in the literature. We refer to a selection of case studies, in detail, the transport of virus models, social dynamics, and Keller–Segel in a fluid. The second part shows how a Hilbert-type approach can be developed to derive models at the macroscale from the underlying description provided by the kinetic theory of active particles. The third part deals with the derivation of macroscopic models corresponding to the selected case studies. Finally, a forward look into the future research perspectives is proposed.
Advanced Anode Materials Based on Iron Oxides for Lithium-Ion Batteries
Authors: Pan Yue , Tong Kun , Tian Ruyu , Sun Limei , Chen Yang 
Published: April 2023

Three main iron oxides, FeO, Fe2O3, and Fe3O4, have attracted much attention as anode materials for lithium-ion batteries (LIBs) for their high theoretical capacity, low cost, large-scale reserves, and environmental benignity. However, the poor cycling life and rate capability limit their commercial application on a large scale. Glaring strategies have been adopted to improve the performance of lithium storage. In this review, the electrochemical performances of FeO, Fe2O3, and Fe3O4anode materials could be improved by the decrease in particle size, regulation and control of the nanomicrostructures, the improvement of electrical conductivity, and the design of composites. Their effects on the electrochemical performance of the anode materials are discussed in detail. Furthermore, the development prospect of iron oxide-basedanode material has been prospected.
Influences of Seedling Age and Variety on the Growth and Bulb Yield of Onion in Northwest Ethiopia
Authors: Aragie Eshetie , Alemayehu Melkamu , Abate Alemu 
Published: April 2023

Onion is one of the major cash crops and helps improve the livelihoods of smallholder farmers. Although genetically and morphologically different, seedlings of all released onion varieties are transplanted at the ages ranging from 40 to 50 days, which contributes to the low level of productivity in Ethiopia. Therefore, a field experiment was conducted at the research site of Fogera National Research and Training Center during the 2019/20 irrigation season with the objective of identifying the optimum seedling age for improved onion productivity in Northwest Ethiopia. The treatments consisted of three varieties (Adama red, Bombay red, and Nasik red) and four seedling ages (30, 40, 50, and 60 days) of onion, which were laid down in 3 × 4 factorial arrangement using randomized complete block design with three replications. Growth and yield parameters of onion were collected based on the standard procedures and analyzed using SAS version 9.6. The results revealed that both variety and seedling age significantly (

P
<

0.001

) influenced plant height, leaf number, bulb diameter, fresh bulb weight, and marketable bulb yield, while their interaction effect did not influence these parameters. Days to maturity was significantly (

P
<
0.001

) affected by main as well as by the interaction effects of variety and seedling age. Younger seedling took longer time to mature, while older seedlings matured relatively early. The seedlings of Bombay red variety at 60 days age gave the earliest maturity days (105.33 days) compared to the other combinations. The highest plant height (50.18 cm), leaf number (12.00), bulb diameter (53.47 mm), bulb weight (84.39 g), and marketable bulb yield (29.97 t/ha) were recorded from Bombay red variety where the marketable yield recorded from Nasik red was statistically similar with that of Bombay red variety. Seedlings with 60 days old performed best in terms of all the tested growth and yield parameters including the highest marketability (32.03 t/ha). Accordingly, 60 days old seedlings and Bombay red and Nasik red varieties can be used to increase the productivity of onion in the study area and areas with similar agroecology.