bluuebunny/crossref_metadata_2025_split huggingface dataset:
The YTHDF3-DT/miR-301a-3p /INHBA axis attenuates autophagy-dependent ferroptosis in lung adenocarcinoma
Authors: Peng Xiong , Yang Rui , Peng WeiLin , Zhao ZhenYu , Tu GuangXu , Shi Shuai , Yin Wei , Cai QiDong , He Boxue , Yu Fenglei , Wang Xiang , Tao Yongguang 
Published: June 2023

Abstract
Extensive studies have shown that many tumors develop resistance to conventional cancer agents targeting molecules in apoptosis and necrosis. Therefore, understanding the mechanisms underlying crosstalk between autophagy and ferroptosis is an exciting field that provides great potential for facilitating therapeutic development to overcome the developed apoptotic and necrotic resistance in hard-to-treat cancers. Here, we reported that the YTHDF3-DT/miR-301a-3p/Inhibin βA (INHBA) axis induces autophagy-dependent ferroptosis in lung adenocarcinoma (LUAD). The long non-coding RNA YTHDF3-DT, of which the level is significant in the overall survival of LUAD patients, increases the stability of INHBA mRNA by acting as an endogenous sponge of miR-301a-3p. Then, the upregulated INHBA activates Activin A to inhibit PI3K/Akt/mTOR pathway-involved autophagy, enhancing RSL3-mediated GPX4 to decrease ferroptosis. This YTHDF3-DT/miRNA-301-3p/INHBA axis regulates cancer biological capabilities through its mediated autophagy-dependent ferroptosis in vitro and in vivo. Our data contribute toward a significant mechanistic understanding of the molecules involved in the crosstalk between ferroptosis and autophagy, providing potential therapeutic targets to complement the existing therapies for overcoming the developed resistance in patients with LUAD.
Host name-liking and subjective well-being of international students in western society: Self-esteem as a mediator
Authors: Pan Qiran , Hu Ting , Wang Yajing , Ren Xiaopeng 
Published: June 2023

Abstract
Studies have indicated that original name-liking is a predictor of self-esteem and subjective well-being. However, it has been customary for Chinese international students to adopt host names, that is, English names, as a part of their East-West cultural transition. Using a sample of 218 Chinese international students in the UK, this study explored whether host name-liking followed a similar psychological mechanism to original name-liking and predicted subjective well-being, particularly via self-esteem. The findings indicated that, similar to original name-liking, host name-liking was positively associated with self-esteem and subjective well-being, and self-esteem played a mediating role in the association between host name-liking and subjective well-being. The findings provided insight into the relationship between host name-liking and subjective well-being, as well as practical suggestions for minorities.
Involvement of a rice mutation GPGG1 in storage protein biogenesis in endosperm and its location in rice genome
Authors: Tian Huai-Dong , Li Ying , Guo Yanping , Qu Yajuan , Zhang Xiaoye , Zhao Xiaoxian , Chang Xinya , Tian Baohua , Wang Guangyuan , Yuan Xiangmei 
Published: June 2023

Abstract
In the wild type of rice endosperm cell, glutelins and prolamins are synthesized on the respective subdomains of rough endoplasmic-reticulum (ER) and intracellularly compartmentalized into the different storage protein bodies, respectively. Herein, we first report a rice mutation involved in the biogenesis of glutelins and prolamins. A novel mutant for storage proteins was isolated and characterized by the great generation of 57 kD glutelin precursors (proglutelins) and the lacking of 13 kD prolamins. The proteinous alteration was clarified to result from a monogenic mutation with the dosage effect on generation of proglutelins and 13 kD prolamins. This mutation is referred to as GPGG1. A novel ER, the saccular composite-ER, was shown to act in the synthesis of proglutelins and 14 kD prolamins in the mutant. In addition to the composite-ER, the mutant type Golgi, trans-Golgi network, endocytotic protein-storage-vacuole, multivesicular body and lytic vacuole were shown to occur and function in the transfer, exocytosis, endocytosis, delivery, deposition and degradation of storage proteins in the mutant. Moreover, the GPGG1 gene was mapped to a 63.8-kb region of chromosome 12, and a pentatricopeptide repeat-like gene was determined as its candidate gene. Our results reveals that the GPGG1 was involved in the storage protein synthesis and caused the remodeling of endomembrane system for storage protein compartmentation. The candidate gene presumably concerns translation of storage protein mRNAs in rice endosperm cells.
The relationship between physical activity and life satisfaction among Chinese university students: the mediating role of self-efficacy and resilience
Authors: Jia-xin Deng , Liu Yong-feng , Yu Wang , Rui Chen 
Published: June 2023

Abstract
Objective
To analyze how the physical activity influence life satisfaction of university students and the relationship between those factors. Additionally, this study aims to examine the mediating effects of self-efficacy and Resilience, and to offer recommendations for enhancing the life satisfaction, positive emotions, and behavioral patterns of university students.
Methodology:
This study used the Physical Activity Rating Scale (PARS-3), the Self-Efficacy Scale (CGES), the Mental Toughness Scale (CD-RISC) and the Life Satisfaction Scale (CSLSS) to administer questionnaires to 353 university students from two universities in Chengdu, Sichuan Province. Using a random simple sampling method. The data were processed and analyzed using SPSS 22.0 and Excel software
Results
1) Physical activity was significantly and positively related to self-efficacy, Resilience and life satisfaction; self-efficacy was significantly and positively related to Resilience and life satisfaction; Resilience was significantly and positively related to life satisfaction. 2) Physical exercise had a positive predictive effect on life satisfaction (β = 0.2771; 95% confidence interval (CI): 0.01905, 0.3637, p < 0.001); 3) Self-efficacy (β = 0.0368, 95% confidence interval (CI): 0.0087, 0.0692, p < 0.001) and Resilience (β = 0.0137; 95% confidence interval (CI): 0.0919, 0.01894, p < 0.001) mediated the relationship between physical activity and life satisfaction, respectively. Also the chain mediating effect of self-efficacy and Resilience between physical activity and life satisfaction reached significant levels (β = 0.0483, 95% confidence interval (CI): 0.0279, 0.0745, p < 0.001).
Conclusion and outlook:
Active participation in physical activity not only improves the level of life satisfaction of college students, but also indirectly influences the level of life satisfaction of college students by enhancing their self-efficacy and Resilience, thus improving the level of life satisfaction of college students.
Clinical and Genomic Evaluations of a persistent fatal SARS-CoV-2 infection in a Goods syndrome patient: A case report
Authors: Tabarsi Payam , Maleki Ali , Abtahian Zahra , khabbaz Alieh , Fereydouni Zahra , Rezaie Jahangir , Tavakoli Mahsa , Sanati Parastoo Yektay , Salehi-Vaziri Mostafa 
Published: June 2023

Abstract
COVID-19 resulted from an infection by SARS-Cov-2 which is the main cause of ADRS in global population from 2019 on. It may contribute to higher rate of death among the patients with immunodeficiency based on recent reports. In addition, Good syndrome (GS) as a result of thymoma removal might cause in some long-lasting microbial infections. We described clinical aspects and viral mutations on a case of GS suffering from COVID-19. A 46-year-old man with fever, general respiratory signs and positive COVID-19 PCR test, with the history of thymoma removal surgery was admitted to Masih Daneshvari Hospital, Tehran, Iran. Lung radiographs and Oxygen saturation measurement disclosed considerable implication resulted in application of several anti-microbial medication. The delta variant (B.1.617.2 (21J Clade)) was the strain isolated from the patient by sequencing methods done by CNRL while the dominant strain circulated mostly among population was Omicron (B.1.1.529) at the time of sampling. Unfortunately, the patient had passed away a month later by sudden respiratory failure progressed in refractory septic shock. Despite the fact that opportunistic infections may lead the GS patients to a major health problematic condition, unusual persistent of infections such as non-dominant variant of SARS-Cov-2 could be observed through the disease timeline. Therefore, a fully screening of thymoma plus intra-host evolution monitoring of SARS-CoV-2 is highly recommended in immunocompromised patients.
Factors influencing shared decision-making within long-term care facilities: A person-centered nursing framework
Authors: Kim Da Eun , Kim Min Jung 
Published: June 2023

Abstract
Background
Shared decision-making, a communicative process to reach decisions based on informed preferences, evidence, and co-created goals, improves care satisfaction and patients’ quality of life. However, shared decision-making has not been widely implemented in long-term care facilities, and few studies have examined how to promote the shared decision-making practice. This study aimed to identify the influencing factors of shared decision-making based on the person-centered nursing framework in long-term care facilities.
Methods
A total of 300 staff (nursing staff, social workers, and personal care workers) in 13 Korean long-term care facilities were participated in this study. Data from 280 respondents were finally analyzed, excluding the respondents with missing values. Data were collected using structured questionnaires that included items on shared decision-making, personal factors (e.g., knowledge about dementia, person-centered attitude, and communication behavior), care environmental factors (e.g., person-centered climate, staffing level, effective staff relationship, supportive supervisor, and power-sharing) of the facilities. Multilevel linear regression analyses were performed using Mplus Version 8.8.
Results
The mean shared decision-making score was 35.78 (range 8–45). Staff with at least one person-centered education (β = 0.198, p = 0.034), higher person-centered attitude score (β = 0.201, p = 0.007) and higher communication behavior score (β = 0.242, p < 0.001) were more likely to report a higher shared decision-making score. In addition, staff who recognize their care environment is more person-centeredness were more likely to report a higher shared decision-making score (β = 0.416, p < 0.001).
Conclusions
This study highlights that general (e.g., person-centered education), personal (e.g., person-centered attitude, and communication behavior) and care environmental (e.g., person-centered climate) factors could influence shared decision-making for long-term care residents. These findings could be foundational evidence for facilitating shared decision-making practice in long-term care settings.
MicroRNA-125a-5p regulates the effect of Tregs to Th1/Th17 through targeting ETS-1/STAT3 in psoriasis
Authors: Yan Kexiang , Zhang Fuxin , Ren Jie , Huang Qiong , Yawalkar Nikhil , Han Ling 
Published: June 2023

Abstract
Background
Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of psoriatic patients. However, the mechanism by which miR-125a participates in psoriasis remains unclear.
Methods
The levels of miR-125a-5p and its downstream targets (ETS-1, IFN-γ, and STAT3) were detected in CD4+ T cells by quantitative real-time PCR (qRT-PCR). In vitro, transfection of miR-125a-5p mimics was used to analyze the effect of miR-125a-5p on the differentiation of Th1 and Th17 by flow cytometric. Imiquimod (IMQ)-induced mouse model was used to evaluate the role of upregulating miR-125a-5p by intradermal injection of agomir-125a-5p in vivo.
Results
miR-125a-5p was downregulated in peripheral blood CD4+ T cells of psoriatic patients, which was positively associated with the proportion of regulatory T cells (Tregs) and negatively correlated with the Psoriasis Area and Severity Index (PASI) score. Moreover, the miR-125a-5p mimics promoted the differentiation of Tregs and downregulated the messenger RNA (mRNA) levels of ETS-1, IFN-γ, and STAT3 in CD4+ T cells. Furthermore, agomir-125a-5p alleviated psoriasis-like inflammation in an IMQ-induced mouse model by downregulating the proportion of Th17 cells.
Conclusions
miR-125a-5p may have therapeutic potential in psoriasis by restoring the suppressive function of Tregs to Th1/Th17 cells through targeting ETS-1, IFN-γ, and STAT3.
Bortezomib induced Henoch-Schönlein purpura during a succesful treatment of multiple myeloma (case report)
Authors: Miličević Luka , Matošević Matija , Ivandić Ema , Prlić Margareta Fištrek , Živko Marijana , Bašić-Kinda Sandra , Batinić Josip , Bradamante Mirna , Bulimbašić Stela , Jelaković Bojan , Brinar Ivana Vuković 
Published: June 2023

Abstract
BACKGROUND. Bortezomib is a well-known frontline therapy for newly-diagnosed multiple myeloma (MM). There have been several case reports about skin vasculitis as a rare side effect of this medicine and one case report about intestinal vasculitis. We are now demonstrating 1st case of a vasculitis affecting skin, intestine and kidney in a single patient.
CASE PRESENTATION. Our patient is a 77-year-old woman with MM treated with bortezomib, melphalan and prednisone. She developed leukocytoclastic vasculitis of legs, bloody diarrhea and nephrotic proteinuria. Since the hematological response had been achieved, her condition was understood as a side effect of bortezomib and was completely resolved by discontinuation of the drug and administration of corticosteroids.
CONCLUSIONS. These three simultaneous signs suggest a common pathophysiology of the vasculitis manifesting on skin, intestine and kidney also known as Henoch-Schönlein purpura (HSP) and to the best our knowledge is 1st report of this combination of side effects of bortezomib therapy. Clinicians should be aware of this rare, yet possible side effect when treating patients with bortezomib so they could timely recognise it and treat it.
Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia with Hyperdiploid Complex Karyotype
Authors: Poiré Xavier , Labopin Myriam , Polge Emmanuelle , Ganser Arnold , Socie Gerard , Gedde-Dahl Tobias , Forcade Edouard , Finke Jürgen , Chalandon Yves , BULABOIS Claude-Eric , Yakoub-Agha Ibrahim , Aljurf Mahmoud D , Kroeger Nicolaus , Blau Igor-Wolfgang , Nagler Arnon , Esteve Jordi , Mohty Mohamad 
Published: June 2023

Abstract
Allogeneic hematopoietic cell transplantation (allo-HCT) remains the best consolidation strategy for acute myeloid leukemia (AML) with complex karyotype (CK). However, CK is a heterogenous and highly diverse entity. Numerical abnormalities have been associated with a controversial prognosis and AML with only multiple numerical abnormalities known as pure hyperdiploid karyotype (HDK) may have a distinct prognosis after allo-HCT compared to non-pure HDK CK AML.
A total of 236 patients were identified within the EBMT registry as having HDK comprising 95 pure (pHDK) and 141 with other cytogenetic abnormalities (HDK+). The 2-year probability of leukemia-free survival (LFS) was 50% for pHDK and 31% for HDK+ (p=0.003). The 2-year probability of overall survival (OS) was 57% for pHDK and 36% for HDK+ (p=0.007). The 2-year cumulative incidence of relapse (RI) was 22% for pHDK and 44% for HDK+ (p=0.001). The 2-year probability of graft-versus-host disease (GvHD)-free and relapse-free survival (GRFS) was 36% for pHDK and 21% for HDK+ (p=0.01). On multivariate analysis, pHDK remained associated with significantly better LFS, OS and GRFS and lower RI (all p-values<0.004).
pHDK AML constitutes probably a distinct cytogenetic entity from HDK+ or other non-hyperdiploid CK AML with better outcomes after allo-HCT.
In vitro spontaneous MET-EMT model confers distinct cancer phenotypes and provides clues for differential epigenetic regulation.
Authors: SAHİN Zeynep Aleyna , MEMISOGLU ASLI SADE 
Published: June 2023

Abstract
Background
Epithelial-mesenchymal plasticity is known to be involved in cancer metasis and chemotherapy resistance. However, molecular mechanisms of transitions between these cellular states is not well understood and good representative models that mimic natural transitions are still needed. In this study, spontaneously differentiating colon cancer cell line, HT-29, was used to develop an MET-EMT model.
Methods and results
Cells were first characterized according to their protein levels of epithelial and mesenchymal markers, so that the accuracy of the model has been proven. In order to elucidate the plastic nature of EMT, changes in the amounts of Polycomb group proteins were analyzed. Further characterization is achieved by comparing drug resistance, proliferation and colony formation ability. It was found that the amount of CBX-7 increased in epithelial cells, the amount of EZH1, EZH2 and CBX-8 increased in mesenchymal cells compared to epithelial cells. In addition, it was determined that epithelial cells were more sensitive to oxaliplatin and 5-FU, their division rate was lower than mesenchymal cells, and their ability to form spheroids was also lower.
Conclusion
This study provides a useful model for the study of epithelial mesenchymal plasticity in which the same cell line is used for reversible transitions whithout any chemical induction.
The Role of Osteoporosis in Non-Metastatic [18F]PSMA-1007 Bone Uptake — Finding the Missing Piece of the Puzzle
Authors: Ninatti Gaia , Pini Cristiano , Gelardi Fabrizia , Ghezzo Samuele , Mapelli Paola , Picchio Maria , Antunovic Lidija , Briganti Alberto , Montorsi Francesco , Landoni Claudio , Sollini Martina , Chiti Arturo 
Published: June 2023

Abstract
Aim
We investigated the association between surrogate markers of osteoporosis and the occurrence of non-metastatic [18F]PSMA-1007 bone uptake.
Materials and Methods
We retrospectively analysed treatment-naïve patients with a confirmed diagnosis of prostate adenocarcinoma who underwent staging [18F]PSMA-1007 Positron Emission Tomography (PET) and blood count within 3 months. Qualitative image analysis was performed independently by three experienced nuclear medicine physicians. Patients were divided in two groups according to the presence/absence of non-metastatic bone uptake. Clinical information, blood count parameters, Body Mass Index (BMI) and bone density as estimated by Computed Tomography were collected. The Kruskal-Wallis and t-test were used to compare parameters.
Results
We analysed 77 patients: 29 of them had non-metastatic bone uptake at [18F]PSMA-1007 PET, most commonly in the pelvic bones (69%) and ribs (62%). Clinical parameters did not differ in the two groups. In patients with non-metastatic bone uptake, white blood cell and neutrophil counts were significantly higher; in the same group, we observed lower values of BMI and bone density, although not statistically different.
Conclusions
We observed non-metastatic bone uptake on [18F]PSMA-1007 PET in more than 1/3 of patients. We found a significant correlation between blood count parameters and non-metastatic [18F]PSMA-1007 bone uptake. Given the prevalence of the finding and the molecular alterations induced by osteoclastogenic processes, we may speculate that [18F]PSMA-1007 non-metastatic bone uptake could be secondary to underlying osteoporosis. This hypothesis needs to be further investigated in larger populations and exploring more specific markers of osteoporosis.
m1A Regulatory Gene signatures are associated with certain immune cell compositions of the tumor microenvironment and predict survival in kidney renal clear cell carcinoma
Authors: Zhou Linjun , Zhou Weidong , Li Yuan , Hua Ruifang 
Published: June 2023

Abstract
Adenosine N1 methylation (m1A) of RNA, a type of post-transcriptional modification, has been shown to play a significant role in the progression of cancer. The objective of the current research was to analyze the genetic alteration and prognostic significance of m1A regulators in kidney renal clear cell carcinoma (KIRC). Genomic and clinicopathological characteristics were obtained from 558 KIRC patients in the Cancer Genome Atlas (TCGA) and Gene Omnibus Expression (GEO) databases. Alterations in the gene expression of ten m1A-regulators were analyzed and survival analysis was performed using the Cox regression method. We also identified three clusters of patients based on their distinct m1A alteration patterns, using integrated analysis of the ten m1A-related regulators, which were significantly related to overall survival (OS), disease free survival (DFS) and tumor microenvironment (TME) immune cell infiltration cells in KIRC. Our findings showed that m1A alteration patterns have critical roles in determining TME complexity and its immune cell composition. Furthermore, different m1A expression patterns were significantly associated with DFS and OS rates in KIRC patients. In conclusion, the identified m1A RNA modification patterns offer a potentially effective way to classify KIRC patients based on their TME immune cell infiltration, enabling the development of more personalized and successful treatment strategies for these patients.
Effects of waiting time for specialized interdisciplinary rehabilitation on adult patients with persistent symptoms of mild traumatic brain injury
Authors: Déry Julien , Potvin Isabelle , de Guise Elaine , Lamontagne Marie-Eve 
Published: June 2023

Abstract
Background
Twenty to thirty percent of patients with mild traumatic brain injury (mTBI) suffer persistent symptoms which can negatively impact their day-to-day activities. The primary aim of this study was to examine the relationship between waiting time for rehabilitation services and persistent symptoms in patients with mTBI. Its secondary objective was to explore the relationship between sociodemographic characteristics and persistent symptom outcomes.
Methods
An observational cohort study was conducted at a specialized interdisciplinary rehabilitation program (SIRP) for mTBI in Québec, Canada. Waiting time was the predictor variable and outcomes were measured at two points in time.
Results
Twenty-six participants completed questionnaires at both baseline and follow-up. Approximately 70% of participants received their first appointment within six months of the injury, while the others waited more than eight months. Longer waiting times were associated with more persistent post-concussion symptoms (p = 0.008), more anxiety (p = 0.005), and poorer community integration (p = 0.006) at baseline, and higher anxiety levels (p = 0.046) at follow-up.
Conclusions
This study shows the negative effects of delayed access to specialized rehabilitation services for patients with mTBI. It highlights the need for timely access to improve outcomes and calls for policy changes to ensure it. Further research is needed to better understand the impact of waiting on mTBI symptoms.