bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Miller Fisher syndrome mimicking Lambert-Eaton syndrome: Case Report
Authors: Abbes Amal , Mhiri Mariem , Dhia Rihab Ben , Saad Yasmine , Frih-Ayed Mahbouba 
Published: January 2023

Abstract
Background :
Miller Fischer Syndrome (MFS) is a variant of Guillain barre syndrome. It is characterized by the triad of ophtalmoparesis, ataxia and areflexia. We describe in this paper an atypical case of a patient with MFS with positivity of glutamic acid decarboxylase (GAD) antibodies.
Case presentation :
A 35-year-old male was admitted to our neurology department with binocular diplopia, headache, and gait ataxia for 3days. Physical examination was remarkable for ophtalmoplegia, cerebellar ataxia and areflexia. MRI brain was normal. Also, cerebrospinal fluid analysis and electromyography within the first week were normal. Exaustif serelogical workup revealed negative anti-GQ1b antibody, but significant increase of GAD- antibody. Evolution was marked by the appearance of a facial diplegia. Neurophysiological studies showed evidence of sensoriel neuropathy of upper and lower limbs. Cerebrospinal fluid (CSF) analysis showed elevated protein. A maximal increment was revealed at twenty Hz repetitive nerve stimulation. Clinical diagnosis of atypical MFS was made. The patient was received a course of Immunoglobulines with completly recovery.
Conclusion : Our finding suggest that GAD-antibodies (GAD-Ab) may play a role in presynaptic neuromuscular transmission defect. It is responsible on an atypical painting by miller fischer mimicking an Lambert Eaton syndrome.
Spatial network structure characteristics and influencing factors of haze in Europe based on weighted network approach
Authors: Lu Ping , Li Zhihong , Wen Ying , Niu Ruiyu , Zhang Jiayi , Wang Yiran , Han Liangliang 
Published: January 2023

Abstract
Haze pollution in Europe has always been one of the topics of concern. It is very rare to investigate the haze transport and its influencing factors among European countries from the perspective of complex network. Different from binary networks, this paper constructs a weighted and directed network of European haze based on the data of European countries from 2010 to 2019. Based on the European haze network, the structural characteristics of the haze network are investigated, the path, direction and strength of haze transfer are identified, and the influencing factors of the haze network are explored. It is found that the spatial association network of haze in Europe presents a complex network structure and shows the features of small-world. The haze network in Europe shows a typical “core-periphery” structure. Germany, France, UK, Netherlands and Italy are at the center of the network. The results of block model analysis show that Luxembourg, Cyprus, Lithuania, Ireland, Switzerland, Slovenia, Latvia, Portugal, Denmark, Estonia, Malta and Iceland play the role of “net receiver” in the European haze network; Belgium, Czech, Netherlands, Austria, Slovakia, Hungary, Finland and Norway play the role of “two-way spillover” in the haze network; Romania, Sweden, Greece, Bulgaria, Croatia and Spain play the role of “agent” in the haze network; Germany, France, Italy, Turkey, UK and Poland play the role of “net spillover” in the haze network. The results of QAP analysis show that the differences in industrial structure, environmental regulation intensity, energy consumption, science and technology level, automobile exhaust emissions and vegetation density play a significant role in promoting the formation of the haze network in Europe. Based on the perspective of complex networks, this paper provides policy suggestions for cross-border collaborative governance of haze in Europe.
Relationships between fatigue differential experience and anxiety, depression, and serum hormones among Chinese cancer survivors: a cross-sectional study
Authors: Gu Shanshan , Xu Yun , Zhu Xiaoshu , Lam Anderson , Gong Lutian , Wang Jinghui , Guo Xinyu , Fu Li , Shi Jiyan , Liu Ketan , Yi Danhui , Wang Feiye 
Published: January 2023

Abstract
Previous research has demonstrated that different cancer survivors with the same disease history or treatment may have different experiences of fatigue. This cross-sectional study aims to explore how demographic, oncological, sociological, psychological, and serum hormone levels interact to influence the distinct experiences of fatigue (Cancer-related fatigue occurrence and fatigue degree). General information, fatigue, psychological factors was evaluated by general information questionnaire, the Revised Piper's Fatigue Scale-Chinese Version, and the self-report Hospital Anxiety and Depression Scale. Serum hormones were measured with chemiluminescent enzyme immunoassay (Zhengzhou Antobio). 306 patients were included, 229 (74.8%) were diagnosed with CRF, including 94 (41.0%) with mild fatigue, 121 (52.8%) with moderate fatigue, and 14 (6.1%) with severe fatigue. Multivariate regression analysis showed that higher depression scores, aldosterone levels may increase the risk of CRF. Patients who are obese (BMI ≥ 28 kg/m2) may help to reduce the risk of CRF. Other contributing factors for increased levels of fatigue (p < 0.05) include being female, having anxiety, depression and high aldosterone levels. The research suggested that CRF was a common symptom in cancer survivors and pay attention to these influencing factors may help to better identify patients susceptible to fatigue and provide long-term, targeted interventions.
Evaluation of Accessibility and Equity to Hospitals by Public Transport: Evidence from Six Largest Cities of Ohio
Authors: Alam Md Saiful , Tabassum Nusrat Jahan , Tokey Ahmad Ilderim 
Published: January 2023

Abstract
Introduction: In the United States, health care has long been viewed as a 'right,' and residents of Ohio are no exception. The Ohio Department of Health ensures that this right exists for all residents of Ohio. Socio-spatial characteristics, however, can have an impact on access to health care, particularly among vulnerable groups. This article seeks to measure the spatial accessibility to healthcare services by public transport in the six largest cities of Ohio based on population and to compare the accessibility of healthcare to vulnerable demographic groups. To the authors' knowledge, this is the first study to analyze the accessibility and equity of hospitals by public transit across different cities in Ohio, allowing the identification of common patterns, difficulties, and knowledge gaps.
Methodology: Using a two-step floating catchment area technique, the spatial accessibility to general medical and surgical hospitals through public transportation was estimated, considering both service-to-population ratios and travel time to these health services. The average accessibility of all census tracts and the average accessibility of the 20% of most susceptible census tracts were determined for each metropolitan region. Using Spearman's rank correlation coefficient between accessibility and vulnerability, an indicator was then devised to evaluate vertical equity.
Findings: Within cities (except Cleveland), people of vulnerable census tracts have less access to hospitals via public transportation. These cities (Columbus, Cincinnati, Toledo, Akron, and Dayton) fail in terms of vertical equity and average accessibility. According to this, vulnerable census tracts in these cities have the lowest accessibility levels.
Conclusion: This study emphasizes the issues connected with the suburbanization of poverty in Ohio's large cities and the need to provide adequate public transportation to reach hospitals on the periphery. In addition, this study shed light on the need for additional empirical research to inform the implementation of guidelines for healthcare accessibility in Ohio. Researchers, planners, and policymakers who want to make healthcare more accessible for everyone should take note of the findings in this study.
Investigation of Mexiletine Hydrochloride Binding on Transition Metal Oxide Nanoparticles by Capillary Electrophoresis
Authors: Elmorsi Eman T. , Lai Edward P.C. 
Published: January 2023

Abstract
The binding affinity of pharmaceutical salts to metal oxide nanoparticles is a fundamental environmental process that determines their transport and bioavailability. Mexiletine hydrochloride (MEX.HCl) interactions with different transition metal oxide nanoparticles (TMONPs) in aqueous dispersion were evaluated by capillary electrophoresis to determine their binding affinities. The results indicated that MEX.HCl bound onto TiO2, Co3O4 and ZnO nanoparticles in alkaline, neutral and acidic pH levels. Interestingly, TiO2 manifested the highest binding affinity of 81 ± 1% at pH 9.4. It was shown that higher initial concentrations of MEX.HCl in an aqueous solution, increasing from 15 to 75 µg/mL, yielded higher binding affinities for TiO2 than Co3O4 and ZnO nanoparticles. The binding rate followed pseudo-second-order kinetics and the binding data were better modeled by the Freundlich isotherm than the Langmuir isotherm. These findings revealed that MEX.HCl binding occurred on the heterogeneous binding sites on TMONPs mainly by the physisorption mechanism via electrostatic attraction and hydrogen bonding.
GDF-15 and Hepciden as a therapeutic target for anemia in chronic kidney disease
Authors: farag naglaa makram , mousa mahmoud , elsayed eman , ismeil ahlam 
Published: January 2023

Abstract
Background
Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and associated with poor clinical outcomes. We evaluated the diagnostic validity of growth differentiation factor-15 (GDF-15) and hepcidin as it is not clear if they are useful as a biomarkers of anaemia among non-dialysis CKD egyptian patients.
Method
An analytical cross-sectional study was conducted among non-dialysis CKD patients (n = 60) and apparently healthy controls (n = 28) at Minia University maternity & children Hospital. Serum levels of GDF-15 and hepcidin were determined. Predictive logistic regression models were built and post estimation receiver operator characteristics were determined to evaluate diagnostic validity of hepcidin and GDF-15 for iron deficiency anaemia.
Results
Hepcidin and GDF-15 are significantly higher in cases than control p value (0.047,<0.0001) respectively. The predictive value of diagnosing anaemia among CKD patients using hepcidin and GDF-15 was 72.0%, 70.0%.There was a weak negative correlation between hepcidin levels and glomerular filtration rate GFR (r-175 =, p = 0.105) in CKD patients, and significant correlation between serum GDF-15 and haemoglobin (r = -0.897, p < 0.0001), ferritin (r = 0.489, P < 0.000), Iron (r=-0.314, P = 0.002), CRP (r = 0.409, P < 0.0001).
Conclusion
Hepcidin and GDF-15 is a potential biomarker for predicting anaemia connected with inflammation among CKD Egyptian patients.
Volcanic evolution of an ultraslow-spreading ridge
Authors: Stubseid Håvard , Bjerga Anders , Haflidason Haflidi , Pedersen Rolf 
Published: January 2023

Abstract
Nearly 30% of the ocean crust forms at mid-ocean ridges where the spreading rate is less than 20 mm per year. According to the seafloor spreading paradigm, oceanic crust forms along a narrow axial zone, becomes inactive, and is transported away from the rift valley. However, because quantitative age data of volcanic eruptions are lacking, constructing geological models for the evolution of ultraslow-spreading crust remains a major challenge. Here, we use sediment thicknesses acquired from more than 4000 km of sub-bottom profiler data combined with C14 ages from sediment cores to determine the age of the ocean floor of the oblique ultraslow-spreading Mohns Ridge at the segment scale and reveal a systematic pattern of young volcanism occurring outside axial volcanic ridges. We present the first age map of a mid-ocean ridge and find that nearly half of the 6-17 km wide inner rift valley floor has been rejuvenated by volcanic activity during the last 25 Kyr. High-resolution bathymetric observations of young volcanic structures at the rift flanks indicate that crustal accretion occurs across the width of the axial valley and implies that formation of ocean crust may take more than one million years at ultraslow-spreading ridges.
Research on the isolation and identification of black spot disease of Rosa chinensis in Kunming,China
Authors: Li Yanjie , Pu Meiying , Cui Yusi , Ju Gu , Chen Xi , Wang Louqin , Wu Hongzhi , Wang Chao 
Published: January 2023

Abstract
Through a survey of rose diseases in the South Tropical Garden in Kunming, China,it was found that black spot was the most common and serious disease of rose cultivated in the open air there, with an incidence of more than 90%. In this study, fungus isolation was performed on leaf samples of five black spot susceptible varieties of rose from the South Tropical Garden by tissue isolation. 18 strains of fungus were initially obtained, and 7 of them were finally identified to cause black spot symptoms on healthy leaves of rose after verification by Koch's rule. By observing the morphology of colonies and spores, and constructing a phylogenetic tree by combining molecular biology and multiple genes, 2 pathogenic fungus were identified, namely, Alternaria alternata and Gnomoniopsis rosae. G. rosae was the first pathogenic fungi of rose black spot isolated and identified in this study. The results of this study can provide a reference base for further research and control of the black spot disease of rose in Kunming.
Parent-mediated interventions versus usual care in children with autism spectrum disorders. A systematic review with meta-analysis and Trial Sequential Analysis.
Authors: Conrad Charlotte Engberg , Ziegler Sonja Martha Teresa , Bilenberg Niels , Christiansen Jens , Fagerlund Birgitte , Hermann Rikke , Jeppesen Pia , Jørgensen Caroline Kamp , Thomsen Per Hove , Jakobsen Janus Christian , Lauritsen Marlene Briciet 
Published: January 2023

Abstract
Background

Autism spectrum disorder encompasses diverse patterns of social-communication and repetitive, restricted behaviours, and is associated with a higher risk of comorbid medical and psychiatric disorders. Various interventions have been developed to reduce the negative consequences of autism spectrum disorder and improve levels of functioning. Within different frameworks of interventions, there is increasing interest in parent-mediated interventions. This systematic review with meta-analysis aims to synthesise the current evidence of the effects, both positive and adverse, of parent-mediated interventions on younger children with autism spectrum disorder and their parents.

Methods

Electronic searches will be conducted in Cochrane Central Register of Controlled Trials (CENTRAL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), Latin American and Caribbean Health Sciences Literature (LILACS), American Psychological Association PsycInfo (PsycInfo), Science Citation Index Expanded (SCI-EXPANDED). Randomised clinical trials of parent-mediated interventions for children with autism and a control-group of usual care, waiting list or no treatment will be included. Two reviewers will independently screen, select and collect data. The methodological quality of the included studies will be evaluated using Cochrane methodology. The primary outcome will be autism symptom severity as measured by the Autism Diagnostic Observation Schedule (ADOS). Secondary outcomes will be adaptive functioning, adverse effects, child language, child socio-communicative symptoms, child´s quality of life and parental quality of life. The meta-analysis will be performed with Trial Sequential Analysis.

Discussion

This is the study protocol for a systematic review and meta-analysis of parent-mediated interventions versus usual care for children with autism spectrum disorder. The results of the review will inform clinicians and parents about the current evidence of the effects, both positive and adverse, of parent-mediated interventions on younger children with autism spectrum disorder and their parents, through improved methodology and the inclusion of new studies.
Protocol registration: PROSPERO 385188
Highly Sensitive Low-Frequency-Detectable Acoustic Sensor Using a Piezoresistive Cantilever for Health Monitoring Applications
Authors: Okamoto Yuki , Nguyen Thanh-Vinh , Takahashi Hidetoshi , Takei Yusuke , Okada Hironao , Ichiki Masaaki 
Published: January 2023

Abstract
This study investigates a cantilever-based pressure sensor that can achieve a signal-to-noise ratio (SNR) of approximately 80 dB or a resolution of approximately 0.1 mPa, over the frequency range of 0.1 to 250 Hz. A piezoresistive cantilever with ultra-high acoustic compliance is used as the sensing element in the proposed pressure sensor. We achieved a cantilever with a sensitivity of approximately 40 times higher than that of the previous cantilever device by realizing an ultrathin (340-nm thick) structure with large pads and narrow hinges. Based on the measurement results, the proposed pressure sensor can measure acoustic signals with frequencies as low as 0.1 Hz. The proposed pressure sensor can be used to measure low-frequency pressure and sound, which is crucial for various applications, including photoacoustic-based gas/chemical sensing and monitoring of physiological parameters and natural disasters. We demonstrate the measurement of heart sounds with a high SNR of 58 dB. We believe the proposed microphone will be used in various applications, such as wearable health monitoring, monitoring of natural disasters, and realization of high-resolution photoacoustic-based gas sensors. We successfully measured the systolic and diastolic beats in the heat sound with frequencies of 7-100 Hz and 20-45 Hz, respectively.
Seasonal rainfall patterns modify summer energy balance and nutritional condition of grazing sheep via vegetation communities
Authors: yoshihara yu , tanaka chisato , Choijilsuren Buyantogtokh , Tserendorj Javzandolgor , Byambajav Bilguun , Umemura Kazuhiro , Kinugasa Toshihiko , Shinoda Masato 
Published: January 2023

Abstract
Recent spring and summer rainfall patterns in Mongolian grasslands have shown high annual fluctuations and are thought to affect sheep energy balance and nutritious condition via plant community changes. To test this, we obtained climatic and vegetation data in Mongolian semi-arid grasslands from spring to summer for 3 years. Sheep energy intake and expenditure were calculated, and the energy balance and nutrition indicators were compared among years with different seasonal rainfall patterns. In 2019 and 2022, rainfall patterns were characterized by the presence or absence of an early summer drought, respectively. Compared to 2019, plants were tall and abundant in 2022, and thus mean bite size, energy intake, and body weights were greater. Estimated energy intake and expenditure were 4.56 and 2.10 Mcal in 2019, and 6.75 and 1.63 in 2022, respectively, demonstrating that rainfall timing and amount affected vegetation assemblage, plant height, herbage nutrition, grazing behavior, animal energy balance, and nutrition conditions. Insufficient rainfall events before early summer in semi-arid grazing lands resulted in low energy intake and balance, and the delayed body weight gain could not be recovered. The findings can inform management of grazing land to ensure optimal livestock condition.
Single-tuned passive filter (STPF) for mitigating harmonic in a 3-phase power system
Authors: Ishaya Meshack Magaji , Adegboye Oluwatayomi Rereloluwa , Agyekum Ephraim Bonah , Elnaggar Mohamed F. , Kamel Salah 
Published: January 2023

Abstract
Harmonics constitutes multiple integrals of the fundamental frequency found in power systems or electric circuitry systems, are primarily caused by non-linear loads that draw current intermittently or have an impedance that changes each cycle of the AC voltage. This can lead to overheating of the system, loss of original waveform, and damage to equipment or system leading to extra expense economically to the consumer. Since harmonics cause distortion in the system and cannot be eliminated from the system, various methods of mitigating to an acceptable level are introduced, use of filters is one of these methods. An STPF adjusted to the 5th, 7th, 11th, 13th, 17th, and 19th harmonic order was employed in this paper in a power system and analyzed. Data was measured on the point of common coupling (PCC) panel using the power quality analyzer tool, and the system was designed on MATLAB/Simulink environment without the filter applied readings were made, and after the STPF was added, both were compared to the IEE 519-1992 standard for which the STPF totally mitigated the harmonics in the system within the standard required.
Fe-modified fly ash/cotton stalk biochar composites for efficient removal of phosphate in water: mechanisms and green-reuse potential
Authors: Hao Mengqi , Wu Wei , Habibul Nuzahat , Chai Guang , Ma Xiaoli , Ma Xiaoqian 
Published: January 2023

Abstract

Excessive phosphate content input into natural water can lead to the waste of resource and eutrophication. Biochar is a kind of low-cost adsorbents. However, its adsorption capacity for phosphate is low. In order to solve this problem, Fe compounds modified fly ash/cotton stalk biochar composites (Fe-FBC) were prepared through co-pyrolyzed fly ash and cotton stalk at 800oC, followed by infiltration of FeSO4 solution. The samples were characterized by Scanning electron microscopy, Brunauer-Emmett-Teller, X-ray diffraction, Fourier-transform infrared spectroscopy, and zeta potential. After modification, the hydrophilicity and polarity of Fe-FBC increased. In addition, the pore volume, specific surface area, and surface functional groups were significantly improved. The adsorption process of Fe-FBC for phosphate in water can be well fitted by the pseudo-second-order kinetic and Sips isotherm adsorption model, with a maximum adsorption capacity of 47.91 mg/g. Fe-FBC maintained a high adsorption capacity in the pH range of 3–10. The coexisting anions (NO3-, SO42-, and Cl-) had negligible effects on phosphate adsorption. The adsorption mechanisms of Fe-FBC include electrostatic attraction, ligand exchange, surface complexation, ion exchange, chemical precipitation and hydrogen bonding. Moreover, the desorption dynamic process of phosphate was investigated, indicating that the phosphate-saturated Fe-FBC could use as slow-release phosphate fertilizer. This study proposed a potentially environmental protection and recycling economy approach, which consists of recycling resources and treating wastes with wastes.