bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract ND01: ABBV-319: A first-in-class Glucocorticoid Receptor Modulator (GRM) agonist ADC for the treatment of B-cell malignancies
Authors: Purcell James W. 
Published: May 2023

Abstract
ABBV-319 is a novel CD19-targeting multi-modal antibody drug conjugate (ADC) for the treatment of B-cell malignancies. The ADC is engineered to have 3 distinct mechanisms of action to maximize anti-cancer activity while reducing systemic toxicities: (1) targeted GRM payload delivery, (2) signaling inhibition of CD19/BCR and (3) enhanced ADCC via afucosylation. Unlike traditional cytotoxic ADCs, the GRM payload is a high potency agonist (sub nM EC50) of the intracellular glucocorticoid receptor (GR) which then traffics to the nucleus resulting in sustained GR-driven transcriptional events leading to cancer cell death. CD19 is a clinically validated B-cell target (approved antibodies, ADCs, CARTs) known to be highly expressed even following multiple lines of therapy, making it an appropriate target for this novel approach. The CD19 antibody in ABBV-319 is an optimized high affinity IgG1 that can inhibit CD19/BCR downstream signaling events including AKT, leading to inhibition of growth in certain B-cell lines. Given ADCC/ADCP is a highly effective mechanism in B-cell malignancies (e.g., rituximab, tafasitamab) the CD19 antibody was engineered to have increased FcγR binding via afucosylation, that retains its enhanced ADCC activity as a GRM drug conjugate. By engineering the molecule in this way, the multi-modal ADC is not solely reliant on one mechanism of action for activity and therefore has the potential for broader activity. Sustained regressions/cures have been observed in multiple B-cell malignancy xenograft model systems (cell-line, PDX, humanized) after a single ADC dose that compares favorably against approved benchmark antibodies, systemic steroids and ADCs. ABBV-319 targets clinically validated mechanisms of action that are known to combine well with multiple standard-of-care agents. This combination potential together with its favorable safety profile, suggests ABBV-319 will be a highly effective combination treatment for B-cell malignancies. ABBV-319 was well tolerated in cynomolgus monkey studies with favorable drug-like properties and antibody-like pharmacokinetics, enabling a high mg/kg clinical starting dose. A first in-human Phase 1 clinical trial evaluating ABBV-319 in B-cell malignancies (DLBCL, FL, CLL) was recently initiated in late 2022 (clinicaltrials.gov, NCT05512390).
Citation Format: James W. Purcell. ABBV-319: A first-in-class Glucocorticoid Receptor Modulator (GRM) agonist ADC for the treatment of B-cell malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr ND01.
Ten‐Year Cardiovascular Disease Risk Score and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014
Authors: Wei Jingkai , Xu Hanzhang , Liese Angela D. , Merchant Anwar T. , Wang Liang , Yang Chih‐Hsiang , Lohman Matthew C. , Brown Monique J. , Wang Tiansheng , Friedman Daniela B. 
Published: May 2023

Background
The Framingham 10‐year cardiovascular disease risk score, which is based on age, sex, smoking, total cholesterol, high‐density lipoprotein‐cholesterol, blood pressure, and diabetes, has been found to be associated with cognitive health, but these findings have not been validated in a representative sample in the United States. We aimed to examine the associations of Framingham risk score with cognitive function among older adults in a nationally representative sample, as well as by race or ethnicity, education, and family income.

Methods and Results

A total of 2254 older adults ≥60 years (57% female, 79% non‐Hispanic White) in the National Health and Nutrition Examination Survey 2011 to 2014 were included in the final sample for analysis. All components of the Framingham risk score were obtained with questionnaire or measured in the laboratory. Cognitive function was examined using the Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Task (immediate and delayed memory), Digit Symbol Substitution Test, and Animal Fluency Test. Multivariable linear regression models were used to assess the associations between Framingham risk score and test‐specific and global cognition
Z
scores. Each incremental 5% in Framingham 10‐year cardiovascular disease risk was associated with lower
Z
scores for Digit Symbol Substitution Test (β=−0.06 [95% CI, −0.09 to −0.03]), delayed memory (β=−0.05 [95% CI, −0.08 to −0.01]), immediate memory (β=−0.07 [95% CI, −0.10 to −0.03]), and global cognition (β=−0.05 [95% CI, −0.09 to −0.02]). Socioeconomic status, particularly race or ethnicity and monthly income levels, were strong effect measure modifiers of the associations.

Conclusions
Lower cardiovascular risk factors are associated with better cognitive function.
Neural Correlates of Object-Extracted Relative Clause Processing Across English and Chinese
Authors: Dunagan Donald , Stanojević Miloš , Coavoux Maximin , Zhang Shulin , Bhattasali Shohini , Li Jixing , Brennan Jonathan , Hale John 
Published: May 2023

Abstract
Are the brain bases of language comprehension the same across all human languages, or do these bases vary in a way that corresponds to differences in linguistic typology? English and Mandarin Chinese attest such a typological difference in the domain of relative clauses. Using functional magnetic resonance imaging with English and Chinese participants, who listened to the same translation-equivalent story, we analyzed neuroimages time aligned to object-extracted relative clauses in both languages. In a general linear model analysis of these naturalistic data, comprehension was selectively associated with increased hemodynamic activity in left posterior temporal lobe, angular gyrus, inferior frontal gyrus, precuneus, and posterior cingulate cortex in both languages. This result suggests the processing of object-extracted relative clauses is subserved by a common collection of brain regions, regardless of typology. However, there were also regions that were activated uniquely in our Chinese participants albeit not to a significantly greater degree. These were in the temporal lobe. These Chinese-specific results could reflect structural ambiguity-resolution work that must be done in Chinese but not English object-extracted relative clauses.
The sawfish (Rhinopristiformes, Pristidae) rostrum displayed in the “Basilica Santuario del Carmine Maggiore” in Naples, Italy: A long story of legends and taxonomic errors
Authors: Fioravanti Tatiana , Maio Nicola , Psomadakis Peter Nick , Manzotti Sandra , Gigante Antonio Pompilio , Splendiani Andrea , Bottaro Massimiliano , Caputo Barucchi Vincenzo 
Published: May 2023

Abstract
Although historically widespread in most of the shallow and warm waters of the world, the presence of sawfishes in the Mediterranean Sea is still a debated question. For some authors, they never inhabited this basin except as vagrants, while for other authors both Pristis pristis and Pristis pectinata were present in the Mediterranean Sea but were extirpated in the 1960s–1970s. The sawfish rostrum kept in the Basilica Santuario del Carmine Maggiore (Naples, Italy), and considered by some authors the first record of sawfish in the Mediterranean was studied using a combination of morphological, genetic, radiocarbon dating and histochemical staining methods to validate the taxonomic identification, estimate its age and assess its geographical origin. Results indicate that the rostrum does not belong to P. pristis as reported by previous authors, but instead possesses morphological and genetic characters typical of P. pectinata. In addition, the radiocarbon age shows that the rostrum is more recent than previously believed, dating it back to the mid-nineteenth century, and genetic and meristic results cast doubt on its presumed Mediterranean origin. This study demonstrates that historical records should always be critically evaluated before using them to draw any far-reaching conclusion about species’ past ecology and/or biogeography, and that future studies using historical information and specimens should adopt an integrative taxonomy approach similar to the one used here.
Ubuntu: Applying a Southern Theoretical Paradigm to Counter Youth Radicalization
Authors: Ghosh Ratna 
Published: May 2023

Abstract
As societal and community institutions, schools operate within certain worldviews. These worldviews impact the aims and objectives of schooling and therefore influence the culture of the school and classroom, not to mention the content of the curriculum and teacher practices. In this paper I consider the “traditional” African worldview of Ubuntu as a framework or a foundation for schooling and education to combat the alienation and discrimination faced by many students in the schools in Western countries which are pushing neo-liberal objectives but that lead them to violence and increasingly, to radicalization. I look at the recent phenomenon of radicalization that makes societies and nations unsafe, and some of the push and pull factors that are increasingly attracting some students in the contemporary world to extremist actions. While the threat of Islamic terrorism seems to have subsided, the threats from extreme right-wing nationalist and alt-right groups is increasing at a fast pace (Ghosh et al, 2016a; Eger and Valdex, 2014; Fadel, 2019; Jones, 2018). I contrast the concept of Ubuntu with Western values of humanism and analyze the core values of the Ubuntu worldview in pedagogical practices. I conclude that present punitive measures are ineffective in preventing radicalization which poses a security threat to all nations, but that schooling has an important role to play in combating this phenomenon through a worldview that is not only humanistic but different in its very understanding of what a human being is and therefore, in preventing schools from alienating individuals and groups.
Specters of Judeo-Spanish: The Case for Judeo-Spanish as a Partial Overlap of Idiolects Shared by People of Sephardi Culture
Authors: Yebra López Carlos 
Published: May 2023

Abstract
The aim of this essay is to problematize the ontology of Judeo-Spanish qua language. First, I argue that its traditional conceptualization as an autonomous, self-contained language is predicated on a (flawed) classical ontological framework that relies on so-called ‘named languages theory.’ Second, I contend that a more enlightened understanding of Judeo-Spanish as a linguistic phenomenon necessitates a paradigm shift toward a hauntological framework consistent with theoretical models such as translanguaging and revivalistics. I conclude that Judeo-Spanish is best understood as an ensemble of the only partially overlapping idiolects of people who share a common Sephardi cultural/ethnic identity and who manage to communicate with reasonable success. Third, I discuss the momentous implications of this shift in three domains: linguistics, minority rights, and education.
The mental health effects of changing from insecure to secure visas for refugees
Authors: Nickerson Angela , Byrow Yulisha , O’Donnell Meaghan , Bryant Richard A , Mau Vicki , McMahon Tadgh , Hoffman Joel , Mastrogiovanni Natalie , Specker Philippa , Liddell Belinda J 
Published: May 2023

Objective: In response to growing numbers of refugees worldwide, host governments are increasingly implementing temporary protection policies; however, little is known regarding the mental health impact of these policies. This online longitudinal study investigated whether refugees who transitioned from low visa security (e.g. short-term transient visas) to medium (e.g. temporary protection visas) or high visa (e.g. permanent visas) security showed changes in depression symptoms, social difficulties and immigration-related fears. Methods: Participants were 1,201 refugees and asylum-seekers from Arabic, Farsi, Tamil or English-speaking backgrounds. Study variables were measured prior to and after change in visa status (6 months apart). Results: Refugees who transitioned from low to medium security visas showed reduced immigration-related fear ( B = −0.09, 95% confidence interval = −0.29 to −0.06), but no change in depression symptoms or social difficulties compared to those who retained low visa security. Refugees who transitioned from low to high security visas showed reduced depression symptoms ( B = −0.02, 95% confidence interval = −0.04 to −0.01), social difficulties ( B = −0.04, 95% confidence interval = −0.05 to −0.01) and immigration-related fear ( B = −0.03, 95% confidence interval = −0.06 to −0.01) compared to those who retained low visa security. Conclusion: Findings indicate that the increased security afforded by temporary protection policies (vs short-term transient visas) did not translate into improved mental health and social outcomes for refugees. In contrast, permanent protection was associated with significant improvements in psychological and social functioning. These results have important policy implications for countries who have committed to protect and facilitate improved mental health among refugees.
Factors Affecting Graft Remodeling and Anterior Cruciate Ligament Reconstruction: MRI Study of 180 Knees
Authors: Vari Nicolas , Marot Vincent , Cavaignac Marie , Vieira Thais Dutra , Bérard Émilie , Cavaignac Etienne 
Published: May 2023

Background: Several factors affect the retear rate after anterior cruciate ligament (ACL) reconstruction, but there are few data on which factors affect graft remodeling. Purpose: To determine which factors are associated with the remodeling of an ACL graft. Study Design: Case-control study; Level of evidence, 3. Methods: A retrospective longitudinal study was conducted to investigate the relationship between various exposure factors and the occurrence of an “event”: graft remodeling measured with the signal-to-noise quotient (SNQ). Data were collected prospectively and analyzed retrospectively for this study. The endpoint was the SNQ on magnetic resonance imaging at postoperative 1 year. The effect of the following parameters on SNQ was investigated: sex, smoking habits, age at surgery, body mass index, time to surgery, time to return to sports, type of sport (in-line, pivot, contact), type of graft (free semitendinosus [ST] or attached ST), and addition of lateral tenodesis. Results: An overall 180 patients were enrolled (90 with each technique). The following factors were significantly and independently associated with the SNQ: attached ST graft (β = −2.624668; P < .001), age at the time of surgery (β = −0.7948476; P = .012), and time elapsed between the injury event and surgery (β = −0.7137424; P = .046). Conclusion: Leaving the ST graft attached distally, being older at the time of surgery, and having more time elapse between the injury event and ACL reconstruction surgery were significantly associated with better graft remodeling.
To Operate or Not to Operate? Reconstructive Surgical Burden and Quality of Life of Pediatric Patients with Facial Differences
Authors: Modi Rishi N. , Blum Jessica D. , Ataseven Burçin , Belza Caitlyn C. , Montes Edna , Leung Karen L. , Zaldana-Flynn Michelle , Rapoport Chelsea S. , Choi Alyssa K. , Ewing Emily , Malcarne Vanessa L. , Gosman Amanda A. 
Published: May 2023

Objective The Craniofacial Condition Quality of Life Scale (CFC-QoL) was used to evaluate the relationship between surgical burden and quality of life (QoL) Design Patient-parent dyads completed the CFC-QoL which queries the following QoL domains: Bullying, Peer Problems, Psychological Impact, Family Support, Appearance Satisfaction, and Desire for Appearance Change. Stepwise multivariate linear regressions were performed for each QoL domain. Setting Urban tertiary care center Patients, participants Pediatric patients with facial differences, and their parents. Intervention Survey study Main Outcome Measure(s) Demographic, diagnostic, and surgical characteristics were collected. Surgical burden was calculated as the standard deviation from the mean number of surgeries per diagnostic cohort. Result Patients ( N  =  168) were majority female (57.1%) and Hispanic (64.3%). Diagnoses were cleft lip and/or palate (CLP, n  =  99) or other craniofacial conditions (CFC, n  =  69). Average patient age was 2.3  ±  5.6 years at first reconstructive surgery and 12.3  ±  3.4 years at study enrollment. Patients received an average of 4.3  ±  4.1 reconstructive surgeries. Worse Bullying was associated with higher surgical burden. Worse Peer Problems was associated with higher surgical burden, but only for children with non-CLP CFCs. Worse Family Support was associated with CFC diagnosis, female sex, and higher surgical burden. Worse Psychological Impact was associated with higher surgical burden. Worse Appearance Satisfaction was associated with younger age and with lower surgical burden. Greater Desire for Appearance Change was associated with older age, higher surgical burden, CLP diagnosis, female sex, and non-Hispanic ethnicity. Socioeconomic status did not predict QoL per patient self- or parent-proxy report. Conclusions Higher surgical burden was associated with worse QoL outcomes in multiple domains.
Effect of anterior communicating artery patency on the flow velocity in bilateral carotid artery stenosis after carotid endarterectomy
Authors: Xia Mingyu , Hua Yang , Jia Lingyun , Liu Beibei , Jiao Liqun , Ma Yan 
Published: May 2023

Background: The effect of anterior communicating artery (ACoA) patency on the flow velocity of the extracranial carotid arteries is unclear. Methods: A total of 285 patients with carotid artery stenosis were included between January 2019 and January 2021. All patients received unilateral carotid endarterectomy (CEA). The patients were classified into ACoA-patent (161) and ACoA-nonpatent (124) groups using digital subtraction angiography (DSA) and/or computed tomography angiography (CTA). The peak systolic velocity (PSV) and end-diastolic velocity (EDV) measured by carotid duplex ultrasonography (CDU) were compared between both groups, pre- and post-CEA. Results: There was no significant difference in the risk factors for cerebrovascular disease between the two groups. Within 1 week after CEA, the PSV and EDV on operative and nonoperative carotid (contralateral carotid in the same patient) arteries decreased significantly (both p < 0.01). Comparison of nonoperative carotid artery pre- and post-CEA between the two groups showed that post-CEA PSV and EDV in the ACoA-patent group were significantly lower than that of pre-CEA (PSV and EDV, t = 11.507 and 6.716, respectively, both p < 0.001) (according to the Society of Radiologists in Ultrasound Consensus Conference [SRUCC] PSV standard). There was no significant difference in the ACoA-nonpatent group (PSV: t = 1.924, p = 0.057; EDV: t = 1.237, p = 0.218). In the nonoperative carotid artery of the ACoA-patent group, the degree of stenosis assessed by CDU was inconsistent with that of DSA/CTA (κ = 0.294), whereas that in the ACoA-nonpatent group had a high consistency (κ = 0.982). Among 161 ACoA-patent cases, 68 showed overestimated stenosis. Conclusions: The patent ACoA increases PSV and EDV, causing an overestimation of carotid artery stenosis.
Development and Validation of Prognostic Nomograms Based on Lymph Node Ratio for Young Patients with Gastric Cancer: A SEER-Based Study
Authors: Chen Yi-Ru , Tian Zhen-Yi , Wang Mei-Qian , Sun Mei-Ling , Wu Jin-Zhen , Wang Xin-Ying 
Published: May 2023

Purpose To investigate the role of lymph node ratio (LNR) in young patients with gastric cancer (GC) and develop nomograms to predict the survival of young GC patients. Methods This retrospective study enrolled stage I-III GC patients before the age of 40 between 2010 and 2016 from the Surveillance, Epidemiology, and End Results (SEER) database. Cox proportional hazards models were used to determine the prognosticators and create the nomograms incorporating LNR to predict overall survival (OS) and cancer-specific survival (CSS). The discriminating superiority of the nomograms was examined using calibration curves, C-index, receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and integrated discrimination improvement (IDI) by comparing with the TNM staging. The performance of the nomograms for risk stratification was analyzed by the Kaplan–Meier method. Results Based on the significant prognosticators identified in multivariate survival analysis, the nomograms were established and showed LNR as the third strongest predictor. The C-index of the nomograms for OS and CSS were higher than those of the TNM staging (OS: 0.773 vs 0.665; CSS: 0.769 vs 0.666). The ROC curves for the nomograms to predict survival exhibited superior sensitivity and specificity when compared with the TNM staging. The calibration plots, DCA curves, and IDI values of the nomograms also demonstrated adequate fit and ideal net benefit in prediction and clinical utility. The Kaplan–Meier analysis observed remarkable differences in patients divided into different risk subgroups ( P < .001). Conclusions These results found the clinical outperformance of the LNR-based nomograms for predicting survival in young stage I-III GC patients. Our nomograms may improve accuracy of survival risk prediction and facilitate individualized care of young stage I-III GC patients.
Effects of Managing Cancer and Living Meaningfully on Cancer-Related Fatigue and Cytokine Levels in Gastrointestinal Cancer Patients
Authors: Cai Yinlian , Zhang Qianqian , Gan Chen , Xu Jian , Yu Sheng , Tang Lingxue , Yao Senbang , Li Wen , Huang Runze , Cheng Huaidong 
Published: May 2023

Objective: To evaluate the effects of managing cancer and living meaningfully (CALM), a psychological intervention with semi-structured interviews, on cancer-related fatigue (CRF), quality of life (QOL), and sleep quality in patients with gastrointestinal (GI) cancer, which may be accompanied by changes in cytokine levels. Methods: A total of 152 GI cancer patients with CRF were enrolled in the study during treatment. Patients were randomly assigned to CALM or usual care (UC) groups. Patients in the CALM group received 12 weeks of CALM plus usual care, and patients in the UC group received usual care plus usual health education. All study participants were evaluated at baseline and at 12 weeks using the Revised Piper Fatigue Scale, the European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Core 30, and the Pittsburgh Sleep Quality Index scale, while cytokine levels were measured. Results: At 12 weeks, the differences in total CRF, QOL, sleep quality, IL-6, IL-4, and TNF-α levels were statistically significant not only in the CALM group compared to patients in the UC group ( t = −7.902, t = 2.163, t = −2.187, t = 3.313, t = −4.120, t = −3.853, respectively; P < .05), but also in the CALM group compared to baseline ( t = 11.331, t = −5.492, t = 5.450, t = −2.418, t = 2.186, t = 2.699, respectively; P < .05). Additionally, the total CRF at 12 weeks was correlated with IL-4, IL-6, and TNF-α levels ( r = −.30, r = .31, r = .32, respectively; P < .001). Conclusions: CALM alleviated CRF and improved QOL and sleep quality in patients with GI cancer, and these improvements were accompanied by changes in IL-4, IL-6, and TNF-α levels.