bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protecting Privacy while Improving Choroid Layer Segmentation in OCT Images: A GAN-based Image Synthesis Approach
Authors: Vupparaboina Kiran Kumar , Ibrahim Mohammed Nasar , Selvam Amrish , Kurakula Shiva Vaishnavi , Mohammed Abdul Rasheed , Mayer Natasha , Sahel José Alain , Chhablani Jay , Bollepalli Sandeep Chandra 
Published: September 2023

<p>THIS WORK HAS BEEN SUBMITTED TO THE MACHINE LEARNING: SCIENCE AND TECHNOLOGY FOR POSSIBLE PUBLICATION. COPYRIGHT MAY BE TRANSFERRED WITHOUT NOTICE, AFTER WHICH THIS VERSION MAY NO LONGER BE ACCESSIBLE.</p>
<p>The choroid, positioned behind the retina, nourishes the retina by supplying oxygen and nutrients. Choroidal structural changes are associated with severe vision-threatening conditions including age-related macular degeneration (AMD) and central serous chorioretinopathy (CSCR). Optical Coherence Tomography (OCT) imaging enables the visualization of choroidal changes, and clinicians rely on quantifying choroidal biomarkers through segmentation of the choroid layer in OCT scans for precise diagnosis and disease management. Accordingly, various attempts are made at automated choroid layer segmentation, however, their practicality is constrained by the limited and biased nature of training data. Privacy regulations hinder data aggregation, and supervised machine learning requires substantial annotated data. To tackle this, we propose an innovative image synthesis approach using generative adversarial networks (GANs). It involves a three-step process: generation of choroid-labeled B-scans using a standard GAN architecture, the transformation of these scans to unlabeled B-scans via Pix2Pix-GAN, and the training of a Pix2Pix-GAN choroid segmentation model using the synthesized data. To demonstrate the generalizability and efficacy, we evaluated the proposed choroid segmentation algorithm on the real B-scans from two different OCT imaging devices: enhanced depth imaging (EDI) and swept-source (SS) OCT, yielding Dice coefficient values of84.84% and 85.15%, respectively, buttressing its effective-ness. Further, qualitative performance analysis, including manual grading, confirms that the synthesized choroid-labeled images are distinct from real images, thus ensuring data privacy. The proposed methodology marks an initial step towards developing a comprehensive choroid layer quantification tool using synthetic images, and its adaptability makes it versatile for various medical image segmentation challenges. </p>
Ethanol fermentation- and ethylene physiology-related gene expression profiles in Red Delicious apples stored under variable hypoxic conditions and protocols
Authors: Salamé Elige , Brizzolara Stefano , Rodriguez Marta , Iob Matteo , Tonutti Pietro , Ruperti Benedetto 
Published: September 2023

Dynamic Controlled Atmosphere (DCA) is beneficial in maintaining specific quality parameters but, due to the extreme oxygen levels applied, can cause adverse effects on the fruit by inducing excessive anaerobic metabolism and the production of off-flavors. The metabolic adaptation and responses of apples (Malus domestica Borkh.) cv. Red Delicious to static or dynamic oxygen concentrations (0.3 and 0.8%, with sequential shifts) during cold storage for 7 months were studied by monitoring quality parameters and the expression of genes involved in sugar, fermentative metabolism, and ethylene physiology. Ethanol content reached the highest levels (around 400 mg/kg FW) under 0.3% oxygen concentration and fruit firmness appeared to be reduced in samples accumulating the highest levels of ethanol. Oxygen switch was effective in reducing the ethanol concentrations with timing-dependent variable effects. The expression of fermentative (alcohol dehydrogenase, lactate dehydrogenase, pyruvate decarboxylase) and sugar metabolism (β-amylase; phosphofructokinase; sucrose synthase) genes resulted to be differently affected by the hypoxic conditions imposed, in particular during the early stages of storage. Sucrose synthase expression appeared to be highly sensitive to changes in low oxygen concentration. Ethylene biosynthesis (ACC synthase and oxidase) genes showed marked differences in their expression in relation to the static and dynamic protocols and the hypoxic conditions, as well as six Ethylene Responsive Factors (ERF) genes, some of them possibly involved in the oxygen sensing mechanism operating in fruit tissues.
ANALISIS DRUG’s RELATED PROBLEMS (DRP’s) PADA PASIEN DENGAN KASUS CHRONIC KIDNEY DISEASE (CKD) DI RUANG RAWAT INAP RUMAH SAKIT BHAYANGKARA TK II SARTIKA ASIH KOTA BANDUNG
Authors: Anggi Setiadi , Rani Wahyoe Prasanti , Pratiwi Wikaningtyas 
Published: September 2023

Chronic kidney disease atau CKD adalah penurunan progresif fungsi ginjal (penurunan sejumlah fungsi nefron) yang terjadi lebih dari beberapa bulan sampai beberapa tahun. Masalah medis yang kompleks umumnya ditemui pada pasien dengan diagnosa CKD baik dengan komorbid atau tanpa komorbid, sehingga hal ini rentan menyebabkan timbulnya masalah-masalah yang berkaitan dengan obat yang dapat mempengaruhi hasil terapi. Tujuan dari penelitian ini adalah mengidentifikasi dan menilai kejadian masalah terkait obat potensial pada pasien CKD dengan atau tanpa penyakit komorbid. Penelitian yang dilakukan merupakan penelitian non-eksperimental deskriptif dengan rancangan cross sectional secara prospektif dengan melihat data rekam medik pasien selama periode Mei 2022-Juli 2022. Teknik pengambilan sampel dengan menggunakan metode non-probability sampling yaitu total sampling, dengan jumlah sampel 76 pasien. Kriteria inklusi adalah pasien baru masuk rawat inap dengan diagnosis CKD, dan dengan atau tanpa penyakit komorbid, berusia diatas 18 tahun (pria/wanita), memiliki LFG < 60 mL mnt/ 1,73 m2. Sedangkan, kriteria eksklusi meliputi pasien dengan rekam medis tidak lengkap atau tidak terbaca. Klasifikasi Drug Related Problems (DRPs) menggunakan Pharmaceutical Care Network Europe (PCNE) versi 9.1. Hasil analisis DRPs potensial menunjukkan bahwa terdapat terdapat 4 kasus indikasi tidak diobati (5,26%), 70 kasus interaksi obat potensial (93,33%), 67 kasus polifarmasi (88,16%). Analisis bivariat menunjukkan bahwa diagnosis penyakit dan jumlah obat secara signifikan meningkatkan kejadian DRPs pada pasien (p <0,05). Analisis multivariat menggunakan regresi logistik menunjukkan bahwa variabel diagnosis penyakit dan jumlah obat terdapat perbedaan signifikan dalam peningkatan kejadian DRPs pada pasien (p <0,05), dengan hasil Odds Ratio (OR) variabel jumlah obat yaitu 2,618 artinya pasien dengan penyakit CKD yang mendapatkan jumlah obat banyak (polifarmasi) memiliki peluang resiko 2-3 kali terhadap terjadinya DRPs, begitupun pada hasil OR variabel jumlah diagnosa penyakit yaitu 2,382 artinya pasien dengan penyakit CKD yang mendapatkan multidiagnosa memiliki peluang resiko 2 kali terhadap terjadinya DRPs.
Produktywność nowych odmian ziemniaka w uprawie ekologicznej i konwencjonalnej
Authors: Zarzyńska Krystyna 
Published: September 2023

Badania przeprowadzono w latach 2020-2022 w Instytucie Hodowli i Aklimatyzacji Roślin w Oddziale Jadwisin-centralna Polska. Celem badań była ocena produktywności kilku odmian ziemniaka uprawianych w dwóch systemach produkcji i oszacowanie ich przydatności do uprawy w systemie ekologicznym. Badaniom poddano sześć odmian ziemniaka należących do różnych grup wczesności. Oceniano wskaźniki produkcyjności roślin oraz plon bulw i jego strukturę. Stwierdzono istotne zróżnicowanie większości badanych cech w zależności od systemu produkcji i odmiany. W ekologicznym systemie uprawy wskaźniki te były znacznie niższe niż w systemie konwencjonalnym. Plon bulw odmian uprawianych w systemie ekologicznym był średnio o 51% niższy niż w systemie konwencjonalnym. Odnotowano również duże zdrobnienie plonu. Stwierdzono istotne różnice odmianowe. Najlepszymi parametrami plonu w systemie ekologicznym charakteryzowała się odmiana Jelly. Spośród badanych odmian można jeszcze polecać odminę Gardena i Irmina.
Application of the detached-leaf technique to evaluate the pathogenicity of isolates of fungi Ascochyta fabae and Botrytis fabae to faba bean
Authors: Góral Tomasz 
Published: September 2023

The most important diseases of the faba bean include Ascochyta blight caused by the fungus Ascochyta fabae and chocolate spot caused by the fungus Botrytis fabae. The pathogenicity of isolates of A. fabae and B. fabae was investigated to six cultivars of faba bean. The technique of detached leaves was used. The leaves were inoculated with pycnidial and conidial spores of the pathogens tested. After incubation, the sizes of necrotic spots produced by pathogens were determined. Significant variation in the pathogenicity of isolates of both fungi was found. The varieties showed differential resistance to Ascochyta blight and chocolate spot. The variation in resistance of cultivars to chocolate spot was lower than resistance to Ascochyta blight. The possibility of using the ImageJ image analysis software to measure the surface of necrotic spots was described.
Adjuvants to eradication treatment for H. Pylori infection
Authors: Ontanilla Clavijo G 
Published: September 2023

Resumen

La suplementación del tratamiento antibiótico frente a Helicobacter pylori con probióticos es una estrategia emergente. Su uso como adyuvantes del tratamiento parte como una necesidad frente a la evidencia de que los tratamientos más habituales muestran en algunos casos bajas tasas de erradicación y efectos secundarios que pueden comprometer la adherencia y por tanto su eficacia. Las ventajas de los probióticos son varias, tales como su seguridad, su capacidad inmunomoduladora así como su acción competitiva contra patógenos. No obstante, a pesar de haber demostrado mejorar las tasas de erradicación y disminuir los efectos adversos en algunos ensayos clínicos, son precisos más estudios para afianzar dichas conclusiones.
SISTEM PENDUKUNG KEPUTUSAN PENENTUAN RUTE PENGIRIMAN BARANG DENGAN DIJKSTRA ALGORITHM BERBASIS WEB PADA PT. AGUNG PANCAR MULIA
Authors: Sarnita Sarnita , Razak Mashur , Asrul Billy Eden William , Wahyuningsih Pujianti , M Suardi 
Published: September 2023

Pemanfaatan teknologi informasi dalam meningkatkan kapasitas penjualan dan pelayanan terhadap konsumen telah menjadi perhatian penting utamanya dalam hal pengantaran barang bagi konsumen. Tujuan penelitian ini adalah membangun sebuah sistem pendukung keputusan dalam penentuan rute terpendek dalam hal pengiriman barang konsumen berbasis website pada PT. Agung Pancar Mulia. Adapun metode yang digunakan untuk menentukan rute terpendek pada penelitian ini adalah menggunakan algoritma Dijkstra yang diaplikasikan pada google maps berbasis website. Pada sistem pendukung keputusan yang dibangun, pengguna dapat melihat titik rute terdekat dari lokasi perusahaan ke rumah konsumen pada saat ingin mengirimkan barang, sehingga diharapkan dapat membantu pengguna dalam hal pencarian rute terpendek dari sebuah titik jarak perjalanan sehingga dapat memudahkan pengguna pada saat mengirimkan barang konsumen. Hasil dari penelitian ini adalah pengaplikasian sebuah sistem informasi pendukung keputusan untuk menentukan rute terpendek pada suatu jarak maps berbasis website menggunakan algoritma dijkstra pada PT. Agung Pancar Mulia.
Pelatihan Pemasaran Berbasis E-Commerce Dan Marketplace Sebagai Solusi Membangun Pertumbuhan Ekonomi Umkm Di Era Pandemi
Authors: Nurendah Yulia , Mekaniwati Ani 
Published: September 2023

Pelaksanaan Pengabdian kepada Masyarakat berupa Pelatihan Pemasaran Berbasis E-Commerce dan Marketplace Sebagai Solusi Membangun Pertumbuhan Ekonomi UMKM di Era Pandemi bagi UMKM di Kota Bogor dapat disimpulkan berhasil sampai pada tahap melakukan memotivasi untuk Pemasaran Berbasis E-Commerce dan Marketplace. Secara umum menunjukkan hasil yang memuaskan. Keberhasilan ini ditunjukkan antara lain oleh : Adanya respon yang positif dari peserta, yang ditunjukkan dengan pertanyaan dan tanggapan yang diberikan selama pelaksanaan kegiatan, Adanya kesesuaian materi dengan kebutuhan pelaku UMKM dalam usaha meningkatkan minat, pemahaman dan kemampuan Pemasaran Berbasis E-Commerce dan Marketplace dan Sebagian besar peserta telah memahami arti pentingnya dan bagaimana melakukan pengembangan Pelatihan Pemasaran Berbasis E-Commerce dan Marketplace

Kata Kunci: ecommerce, pelatihan, umkm
Pendampingan Penyusunan Pelaporan Keuangan UMKM Kabupaten Bogor
Authors: Jasmadeti Jasmadeti , Tartilla Nilda , Amrulloh Amrulloh 
Published: September 2023

Tujuan dari PKM yaitu memberikan pengetahuan dan pendampingan mengenai pencatatan laporan keuangan yang sesuai dengan standar akuntansi yang berlaku. Dalam hal ini didasari karena kurannya pemahaman dan pengetahuan yang dimiliki UMKM Kab. Bogor. Solusi yang kami jalani pada aktivitas PKM terkait permasalahan yang ada adalah memberikan pengetahuan dan ketrampilan mengenai pencatatan keuangan yang tertata dan menyusun laporan keuangan serta membuat laporan keuangan sesuai dengan standar akuntansi yang berlaku. Dalam pelaksanaan PKM ini metode yang pendapingan yang kami gunakan (1) Tahap persiapan dan sosialisasi terkait penyusunan materi pelatihan dan penentuan metode penyampaian yang mudah dan menyenangkan, (2) Tahap pelaksanaan pendampingan penyusunan laporan keuangan yaitu pengenalan konsep pencatatan, penyusunan dan pembuatan laporan keuangan terkait transaksi keuangan yang terjadi di UMKM Kab. Bogor dalam hal bertujuan memberikan pengalaman langsung yang terkait cara pencatatan, menjurnal transaksi keuangan UMKM, (3) Tahap ketiga melakukan monitoring bertujuan untuk melihat tercapainya target dari program PKM yang dilakukan. Sasaran yang ingin dicapai yaitu meningkatkan pemahaman dalam melakukan pencatatan, penyusunan dan pembuatan laporan keuangan yang sesuai dengan standar akuntansi yang berlaku.

Kata Kunci : Laporan Keuangan, UMKM
Características clínicas y epidemiológicas de los pacientes con infección por Bordetella pertussis hospitalizados
Authors: Gaitán Samudio Joycee Massiel , Castillo Peñalba Jorge Omar , Ferguson Amores Ericka 
Published: September 2023

Introducción: La tosferina causada por la bacteria Bordetella pertussis, es una de las principales enfermedades prevenibles por vacunas en el mundo. En Panamá es una causa importante de morbimortalidad en la población infantil. A nivel nacional se registraron 20 casos en el 2018 y 108 en el 2019. El objetivo es describir el comportamiento clínico y epidemiológico de la infección en la población pediátrica.
Materiales y métodos: Es un estudio descriptivo, retrospectivo y observacional. Se incluyeron pacientes de 0 a 14 años con diagnóstico de infección por B. pertussis. Las variables: edad, sexo, procedencia, comorbilidades, signos, síntomas, vacuna contra B. pertussis, hemograma, complicaciones, defunción.
Resultados: La tasa hospitalaria fue de 5 casos por cada 10 000 hospitalizados. El sexo presentó una razón de 2:1. El grupo etario más afectado fue el de 2 a 3 meses. La tos fue la manifestación más frecuente. La comorbilidad que se observó con mayor frecuencia fue la desnutrición. El 56% de los pacientes no contaban con vacuna contra B. pertussis. La leucocitosis se observó en 66% de los casos, la linfocitosis en 16% y la trombocitosis en 34%. Tasa de mortalidad hospitalaria, por enfermedad específica de 1,4 casos por 10 000 hospitalizados. Tasa de letalidad, de 25 por cada 100 casos.
Conclusiones: Se encontró predisposición en el sexo femenino. Los lactantes menores son el grupo más afectado. La mayoría de los pacientes y sus madres, no habían recibido vacunación contra B. pertussis. La letalidad observada fue mayor a la descrita en la literatura.
Portrait intellectuel d’une pédagogue de l’entre-deux-guerres
Authors: Latała Renata 
Published: September 2023

Scientifique, enseignante, travailleuse sociale, Maria Grzegorzewska est une de ces femmes qui fascinent leurs contemporains et qui ne les laissent pas indifférents. Où puise-t-elle son charisme, son influence ? Cette étude se propose d’esquisser l’itinéraire de cette femme engagée sur le terrain éducatif spécialisé, devenant une « éveilleuse » pour des générations successives de pédagogues. En s’interrogeant sur l’origine de sa vocation, les circonstances dans lesquelles se cristallisent ses aspirations et ses convictions et la manière dont elle s’engage, l’on dresse un portrait personnel, redessiné dans un environnement intellectuel et culturel générationnel.
A study report on the effect of COVID-19 pandemic in providing in-and-out-patient psychiatric services in a level-3 COVID hospital
Authors: Singh Deepa , Pandey Richa , Yadav Gaurav S. , Agrawal Prabhat K. , Khan Amil H. , Aich Tapas K. 
Published: September 2023

ABSTRACT

Background:
COVID-19 pandemic disrupted all routine and emergency hospital services, including our out-and-in-patient psychiatric services.

Aim:
To study the effect of the COVID-19 pandemic and subsequent lockdown in providing in-and-out-patient psychiatric services and the experience of tele-consultation services in our level-3 COVID hospital.

Materials and Methods:
We conducted a retrospective observational study using an administrative database at psychiatry in-and-out-patient department. All the cases that were reported to us, through emergency Out-Patient Department (OPD) and tele-consultation OPD, from April 2020 to October 2020, were included in the study. Data, thus obtained, were compared with the out-and-in-patient data during the same period on the previous year.

Results:
During the study period, there was a decline in out-patient registration of patients by 94.5%, and a reduction in admission rate was 75.5%, in comparison with the previous year. During 3 months of tele-consultation service provided, 23.5% of patients had the diagnosis of depression, 21.4% of them had various types of headaches, 15.9% of patients had psychosis, 15.3% had anxiety disorders, and 8.8% had a bipolar-affective disorder.

Conclusion:
Being a level-3 COVID hospital, our hospital suffered significantly in relation to psychiatric in-and-out-patients attendance and service recipients during the study period of COVID-19 pandemic.
Assessment of potential antimicrobial activity of Ocimum basilicum extract and chlorhexidine against Socransky’s complex pathogens of oral cavity: An in vitro study
Authors: Khot Atrey J. Pai , Ankola Anil V. , Dodamani Suneel , Sankeshwari Roopali M. , Kumar Ram Surath , Santhosh Varkey Nadakkavukaran 
Published: September 2023

Background and Objective:
Periodontitis is a multifactorial disease initiated by periodontal pathogens and progresses further in destruction of periodontium. Hence, the objective of this study was to test the efficacy of Ocimum basilicum seeds extract on periodontal pathogens.

Materials and Methods:

O. basilicum seeds were authenticated from a recognized taxonomist. They were coarsely powdered; ethanol-based extract preparation was done by the Soxhlet method and aqueous-based extract by hot infusion procedure. Extracts so obtained were assessed for minimum inhibitory concentration, minimum bactericidal concentration, zone of inhibition, and time-kill assay of O. basilicum seeds extract on periodontal pathogens, and comparatively evaluated the effectiveness against 0.12% chlorhexidine (CHX) gluconate in triplicates. Kruskal-Wallis Test was employed wherein the statistical significance was set at P ≤ 0.05.

Results:
The concentration of O. basilicum ethanolic extract against periodontal pathogens was determined to be 10 mg/ml, whereas 4.7 mg/ml of aqueous extract was proven effective against periodontal pathogens. Similarly, aqueous extract of O. basilicum developed a wider zone against periodontal pathogens compared to ethanol-based O. basilicum extract. Statistically significant difference found in the effectiveness between both extract and CHX.

Conclusion:
The antibacterial activity was evident in both the extracts of O. basilicum against anaerobic periodontal pathogens. However, it was more pronounced in aqueous extract, but lower compared to CHX.
Evaluation of bioactivity and biodegradability of a biomimetic soft tissue scaffold for clinical use: An in vitro study
Authors: Houshmand Behzad , Nejad Azadeh Esmaeil , Safari Fatemeh 
Published: September 2023

Background:Autogenous soft-tissue graft is the gold-standard approach to augment oral soft tissues. However, tissue engineering is increasingly surveyed to overcome its substantial drawbacks, including the secondary site of operation, patient’s pain and discomfort, limited tissue of donor site, and so on. Chitosan and gelatin have been utilized in this field over the years due to their great biological virtues. Zeolite, another remarkable candidate for tissue engineering, possesses outstanding biological and mechanical properties, thanks to its nanostructure. Therefore, this study aimed to investigate the biodegradability and DNA content of seeded human gingival fibroblasts on a New Chitosan-Gelatin-Zeolite Scaffold for the perspective of oral and mucosal soft tissue augmentation.Materials and Methods:DNA contents of the human gingival fibroblast cell line (HGF.1) seeded on the chitosan-gelatin (CG) and CGZ scaffolds were evaluated by propidium iodide staining on days 1, 5, and 8. Scaffolds’ biodegradations were investigated on days 1, 7, 14, 28, 42, and 60.Results:Although both scaffolds provided appropriate substrates for HGF.1 growth, significantly higher DNA contents were recorded for the CGZ scaffold. Among experimental groups, the highest mean value was recorded in the CGZ on day 8. CGZ showed a significantly lower biodegradation percentage at all time points.Conclusions:The incorporation of zeolite into the CG scaffold at a ratio of 1:10 improved the cell proliferation and stability of the composite scaffold. CGZ scaffold may offer a promising alternative to soft-tissue grafts due to its suitable biological features.
Emerging role of photodynamic therapy as an adjunct to nonsurgical periodontal therapy on periodontal status and glycemic control in patients with type 2 diabetes: A clinical study
Authors: Thankappan Prasanth , Gopalakrishnan Dharmarajan , Manandhar Sumita 
Published: September 2023

Background:
Periodontal disease is considered to be the sixth most common complication of diabetes mellitus (DM). Antibiotics (systemic and local) enhance the outcome of conventional mechanical debridement but frequent use of antimicrobials may develop resistance to microorganisms. To overcome this complicacy, the current study assessed the effectiveness of photodynamic therapy (PDT) in chronic periodontitis patients with type 2 diabetes when used as a combination therapy to standard periodontal therapy by assessing the various clinical and glycemic parameters.

Materials and Methods:
A total of 16 known cases of chronic Periodontitis patients who were suffering from type 2 DM were allocated into two groups. The test group (n = 8) was treated with standard scaling and root planing (SRP) along with PDT while the control group was treated with SRP alone. Various clinical parameters assessed were plaque index, gingival index, pocket probing depth, clinical attachment level, and Glycated hemoglobin level at baseline and 90 days after therapy.

Results:
At the end of the study, both the groups showed improvements with regard to all clinical and glycemic parameters compared to baseline. However, the test group presented statistically significant favorable results (all P < 0.05).

Conclusion:
Conventional periodontal treatment aided with PDT proved to be a beneficial therapeutic measure and effective alternative in patients with chronic periodontitis with diabetes when compared with standard periodontal therapy alone.