bluuebunny/crossref_metadata_2025_split huggingface dataset:
Being a ‘good’ doctor: Understanding and managing professional boundaries is challenging and can lead to stress and burnout
Authors: Lampe Lisa , Hitching Rita , Hammond Trent Ernest , Park Jeannie , Rich Dominique 
Published: August 2023

Objective The aim is to increase the understanding of non-sexual boundary challenges and potential personal and professional impacts on doctors and medical students. Method We examined peer-reviewed and grey literature and published commentary and cases from Australian health practitioner boards and medico-legal insurance companies. Key ideas relating to the objective of our study were subsequently framed into a narrative. Results Compared to ‘sexual’ boundary crossings, the literature examining ‘non-sexual’ boundaries is scanty, fragmented, and difficult to find. There are gaps in knowledge around the prevalence and consequences of non-sexual boundary challenges and crossings, although the safety and wellbeing of health professionals and patients are of concern. Non-sexual boundary crossings may represent a ‘slippery slope’ to boundary violations. Opportunities for doctors and medical students to access relevant training appear limited. Conclusions We identified several categories of boundary challenges based on context, the nature of the existing relationship, and the type of behaviour. Non-sexual boundary challenges may be related to stress, burnout, and risk for future boundary violations. Future research to investigate the impacts on doctors and medical students in maintaining professional boundaries in their relationships with patients and colleagues, their specific training needs, and the effectiveness of training in reducing work-related stress and burnout is needed.
Assessment of the change of antiemetic prophylaxis from double to triple combination in patients with high dose carboplatin chemotherapy
Authors: Albanell-Fernández Marta , Pérez Sánchez Ángela , Monge-Escartín Inés , Riu-Viladoms Gisela , Rodríguez Mues Mª Carmen , Corominas Bosch Mª Lourdes , Gaba García Lydia , Rollán Neus Basté , Reguart Noemí , Soy Muner Dolors , Carcelero San Martín Esther 
Published: August 2023

Introduction Chemotherapy-induced nausea and vomiting (CINV) is one of the adverse events that most affects oncologic patients’ quality of life. Carboplatin AUC ≥ 4 belongs to agents with high emetic risk (moderate risk in ASCO guidelines). We aimed to compare the effectiveness of netupitant/palonosetron and dexamethasone triple combination (TC) therapy versus ondansetron and dexamethasone double combination (DC) therapy as antiemetic prophylaxis in patients with carboplatin AUC ≥ 4. As a secondary endpoint, in TC group we evaluated the effectiveness of changing NEPA administration timing from 1 h to 15 min before chemotherapy. Methods Open-label prospective study conducted in a tertiary-care hospital in patients receiving carboplatin AUC ≥ 4. CINV was evaluated using MASCC antiemetic tool, in acute (<24 h) and delayed phase (24–120 h). Results were analyzed using χ2 test. Results Two-hundred four completed questionnaires (CQ) were analyzed (76 in DC and 128 in TC). The proportion of patients who remained emesis-free was superior for TC-treated group compared to DC, either in acute (99.2% vs 92.1%, p = 0.0115) and delayed phase (97.6% vs 90.7%, p = 0.043). Likewise, a higher proportion of TC-treated patients compared to DC remained nausea-free for the first 24 h after treatment (90.6% vs 71%, p = 0.0004) and between 24 and 120 h (82.3% vs 62.7%, p = 0.0025). The change of NEPA administration time showed similar effectiveness in terms of CINV control (81.6% vs 74.5%, p = 0.70). Conclusions TC showed superiority in early and delayed CINV control in carboplatin AUC ≥ 4 regimens, with no significant differences among cancer types. Change in NEPA administration timing has beneficial implications; it allows NEPA to be administered at hospitals before chemotherapy session.
Do ASD and ADHD Have Distinct Executive Function Deficits? A Systematic Review and Meta-Analysis of Direct Comparison Studies
Authors: Townes Parker , Liu Chunlin , Panesar Prabdeep , Devoe Daniel , Lee Soo Youn , Taylor Gracie , Arnold Paul D. , Crosbie Jennifer , Schachar Russell 
Published: August 2023

Objective: To evaluate if children and adolescents with a diagnosis of ASD or ADHD have distinct executive function (EF) profiles. Methods: Peer-reviewed articles comparing ASD, ADHD, and typically developing individuals under 19 years of age were identified. The domains evaluated were: working memory, response inhibition, planning, cognitive flexibility, attention, processing speed, and visuospatial abilities. Results: Fifty-eight articles met inclusion criteria. Analyses were performed on 45 performance metrics from 24 individual tasks. No differences in EF were found between individuals diagnosed with ASD and ADHD. Individuals diagnosed with ASD and ADHD exhibited worse performance in attention, flexibility, visuospatial abilities, working memory, processing speed, and response inhibition than typically developing individuals. Groups did not differ in planning abilities. Conclusion: Children and adolescents with ASD and ADHD have similar EF profiles. Further research is needed to determine if comorbidity accounts for the commonality in executive dysfunction between each disorder.
Environmental Sustainability in Selected OPEC Countries: Do the Influence of FDI and ICT Matter?
Authors: Sepehrdoust Hamid , Tartar Mohsen , Zamani Shabkhaneh Saber , Heydari Parvin Shaghayegh 
Published: August 2023

Considering the undeniable role and importance of the environment in people’s lives, the present study is designed to investigate the combined effect of information and communication technology (ICT) and foreign direct investment (FDI) on achieving environmental sustainability. Since the increasing emission of carbon in society and its destructive environmental effects on social economic aspects and even political tensions have become a challenge, the main question of the research is what strategies have governments, especially oil exporting countries, used in the past to reduce the level they have discovered pollution and what policies do they want to follow in the future? Among the policies undertaken by the OPEC oil exporting countries, has the action for foreign direct investment (FDI) and the development of information and communication technology (ICT) been effective in preventing harmful environmental effects? For this purpose, data on renewable energy consumption, the intensity of use of information and communication technology, foreign direct investment (FDI), and urbanization have been used as explanatory variables, and carbon dioxide (CO2) emission as a dependent variable. The target countries selected are oil exporting countries (OPEC) for the period 2000 to 2020, and the analysis method used is panel VAR. The results showed that creating a shock in FDI, labor force, urban population, and renewable energy consumption decreases CO2 while creating a shock in Gross capital formation increases CO2. The impact of shock of ICT on CO2 is also insignificant and can be ignored. The results of variance analysis also showed that urban population, labor force, and FDI variables have the largest contribution in explaining the behavior of CO2; therefore, it is necessary to pay attention to FDI and try to increase the attraction of foreign direct investment to reduce CO2 in OPEC countries. JEL: C23, F43, F64
Low-frequency sound-absorbing metamaterial based on a series-parallel arrangement structure
Authors: Zhuang Hongyu , Cui Hongyu , Hu Haoming 
Published: August 2023

Low-frequency noise has a long wavelength, decays very slowly, and is extremely penetrating. Traditional marine acoustic insulation materials have difficulty achieving effective control of this low-frequency noise. In this paper, a series-parallel arrangement structure of a low-frequency metamaterial is designed, which mainly comprises convoluted channels and Helmholtz cavities in series and a sandwich arrangement of multiple cells (as opposed to the traditional parallel arrangement). We use a numerical method to establish an acoustic-solid coupling model for the metamaterial, consider the influence of thermal and viscous losses on its sound absorption performance, and investigate the sound absorption characteristics and mechanisms of the single-cell and multicell structures. The metamaterial designed in this paper shows an average absorption coefficient of 0.97 in the range of 130–145 Hz. An experimental model was prepared by 3D printing, and the intended sound absorption effect was experimentally verified.
Use of S2.2/DOX Magnetic Nanoliposomes in MR Molecule Imaging and Targeted Thermochemotherapy for Breast Cancer In Vitro
Authors: Zhu Yinxing , Yang Dazhuang , Guo Ting , Lin Mei 
Published: August 2023

Objective To prepare S2.2/DOX magnetic nanoliposomes by combining the potential benefits of MNPs in MRI and the targeted performance of nano-drugs as an innovative method for integrated diagnosis and treatment of breast cancer (BC). Methods We created a S2.2-PEG-MZF/DOX molecular probe by using a lipid material to encapsulate PEG-MZF-NPs and doxorubicin (DOX), and a S2.2 aptamer to target MUC1 to conjugate with PEG-MZF/DOX nanoliposomes. The potential of probe for cell-specific targeting and magnetic resonance (MR) molecular imaging was evaluated by MR scanner and Prussian blue staining. Additionally, we explored the feasibility by using nanoliposome magnetic induction heating to interfere with MCF-7 (MUC1+) BC cells under the influence of an alternating magnetic field (AMF). Results PEG-MZF-NPs were biologically safe. The T2 relaxation rate of PEG-MZF-NPs was found to inhibit T2 signal in a concentration-dependent manner, and the T2 signal of the S2.2-PEG-MZF molecular probe in MCF-7 cells was significantly lower than that in PEG-MZF-NPs group. Moreover, the T2 signal reduction was more pronounced in MCF-7 cells than in the hepatoma cell line HepG2 (MUC1-), suggesting a strong MRI potential of the S2.2-PEG-MZF molecular probe. The S2.2-PEG-MZF/DOX nanoliposome was able to achieve the desired temperature range for tumor hyperthermia (42-44 °C) in vitro. The S2.2-PEG-MZF/DOX nanoliposome accompanied by magnetic fluid hyperthermia (MFH) could inhibit proliferation and invasion and induce apoptosis of MCF-7 cells. The effects of this approach were significantly higher than those observed in the other groups. Conclusion We successfully developed a novel technique for BC diagnosis and treatment using thermochemotherapy under the guidance of MR molecular imaging. This approach holds great potential for improving the management of this devastating disease in the future.
Comparative renal risk of long-term use of beta-lactams in combination with vancomycin across the continuum of care
Authors: Dolly Lauren M. , Rivera Christina G. , Jensen Kelsey L. , Mara Kristin C. , Schreier Diana J. , Virk Abinash , Arensman Hannan Kellie N. 
Published: August 2023

Background: Data are controversial regarding nephrotoxicity risk with vancomycin plus piperacillin–tazobactam (VPT) compared to vancomycin alone or in combination with other beta-lactams (BLs) in acute care use. Furthermore, data are lacking on the incidence of acute kidney injury (AKI) with long-term use of VPT including outpatient parenteral antimicrobial therapy (OPAT). Methods: This retrospective study included 826 adult patients on an intravenous vancomycin plus BL for ⩾2 weeks, including cefepime, piperacillin/tazobactam, ertapenem, or meropenem, from August 2017 to January 2022. The primary outcome was incidence of AKI. Univariate and multivariable Cox proportional hazard regression analyses were conducted to adjust for confounding variables. A secondary analysis based on the propensity score (PS)-matched cohort was performed. Results: AKI occurred in 14.4% of patients in the VPT group ( n = 15/104) compared to 5.5% in the other BL group ( n = 40/722) ( p < 0.001). Average time to AKI from start of combination therapy was 9.4 (1.7–12.0) days in the VPT group and 10.9 (5–22.7) days in the other BL group ( p = 0.20). The median duration of vancomycin and BL in the overall cohort was approximately 1 month. Beyond BL selection, patient characteristics were not associated with AKI other than the receipt of concomitant acyclovir [hazard ratio (HR) 2.48 (95% confidence interval (CI): 1.33–4.65), p = 0.004]. In the PS-matched cohort, AKI occurred in 14.4% of patients in the VPT group ( n = 15/104) and 5.3% in the other BL group ( n = 11/208) ( p = 0.006). Receipt of VPT [HR: 2.55 (1.36–4.78), p = 0.004] and acyclovir [HR: 2.38 (1.19–4.74), p = 0.014) remained significantly associated with AKI in the multivariable model. Conclusion: Clinicians should exercise caution when using VPT for >2 weeks, including in the OPAT setting, even when no renal dysfunction is observed during the initial week of combination therapy.
Cleft Lip and Palate Care: A Healthcare Cost and Utilization Project Analysis
Authors: Khoo Kimberly H. , Lopez Christopher D. , Rivera Perla Krissia M. , Yusuf Cynthia T. , Lopez Joseph , Redett Richard J. , Yang Robin 
Published: August 2023

Introduction: Increasing emphasis on reduction of healthcare costs has caused rates of outpatient cleft lip and palate-related procedures to rise. This study aims to describe patient and hospital characteristics associated with cleft repair and related surgeries and to assess differences in these characteristics against those undergoing inpatient cleft procedures. Methods: Data was collected from the 2016 to 2018 National Inpatient Sample (NIS) and the 2016 to 2018 Nationwide Ambulatory Surgery Sample (NASS) from the Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality (AHRQ). The databases were queried for International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes and Current Procedural Terminology (CPT) codes, respectively, describing cleft lip and palate-related procedures. Variables described were categorized into 2 main groups of patient demographics and hospital characteristics. Results: A total of 271 patients were included from the NIS and 3122 patients from the NASS. In both settings, the most common insurance used for cleft lip surgeries was Medicaid (46.7% vs 50.7%); the same was true for cleft palate (50.7% vs 53.5%). The distribution of zip code-based income quartiles was similar between settings for both cleft procedures. The most common location and teaching status of the hospitals was urban, teaching hospitals. Conclusion: This study demonstrates that patient and hospital characteristics are similar between inpatient and outpatient cleft surgeries. Patients were primarily in the 2 lower income quartiles and enrolled in Medicaid. More granular studies defining the social determinants of health in the cleft lip and palate populations may improve care for these patients.
Water-based drilling fluid with palygorskite: cutting carrying and contaminants
Authors: Santanna Vanessa Cristina , Araújo Gabriela Carlos Nunes , Andrade da Silva Maria Thayse , Castro Dantas Tereza Neuma de , Pimentel Patrícia Mendonça 
Published: August 2023

AbstractIn the petroleum industry, one of the most important functions fluids must perform is to carry cuttings efficiently. In this context, the contamination of drilling fluids represents a challenge to the industry because it alters the properties of these fluids. This work compares two drilling fluids (one palygorskite-based and the other polymer-based), evaluating the effects of contaminants on these drilling fluids and their ability to carry cuttings. A contaminant is considered to be any material that causes undesirable changes in the properties of the drilling fluid. Contamination of an aqueous drilling fluid by calcium hydroxide (Ca(OH)2) and brine can increase the filtrate volume, decrease the perforation rate and alter the rheological properties of the fluid. This work analyses the effects of contamination by Ca(OH)2 and brine on the properties of salted water-based drilling fluids viscosified with palygorskite. For comparison, tests were performed with a polymeric drilling fluid. The cutting-carrying capacity of these fluids was verified using the empirical correlations of Moore (1974), Chien (1994) and Walker & Mayes (1975). The results show that the drilling fluid with palygorskite is resistant to contamination with Ca(OH)2 and brine, presenting low filtrate volume values. The drilling fluid with palygorskite presented greater slip velocities than the polymeric drilling fluid. Regarding the cutting-carrying capacity, the drilling fluid with palygorskite presented positive transport ratio values (>0), making it suitable for carrying rock cuttings. However, the polymeric drilling fluid showed better performance in terms of cutting-carrying capacity.
Nanoscale modeling of dynamically tunable planar optical absorbers utilizing InAs and InSb in metal-oxide-semiconductor–metal configurations
Authors: Dixit Kirtan P. , Gregory Don A. 
Published: August 2023

AbstractThe attainment of dynamic tunability in spectrally selective optical absorption has been a longstanding objective in modern optics. Typically, Fabry–Perot resonators comprising metal and semiconductor thin films have been employed for spectrally selective light absorption. In such resonators, the resonance wavelength can be altered via structural modifications. The research has progressed further with the advent of specialized patterning of thin films and the utilization of metasurfaces. Nonetheless, achieving dynamic tuning of the absorption wavelength without altering the geometry of the thin film or without resorting to lithographic fabrication still poses a challenge. In this study, the incorporation of a metal-oxide-semiconductor (MOS) architecture into the Fabry–Perot nanocavity is shown to yield dynamic spectral tuning in a perfect narrowband light absorber within the visible range. Such spectral tuning is achieved using n-type-doped indium antimonide and n-type-doped indium arsenide as semiconductors in a MOS-type structure. These semiconductors offer significant tuning of their optical properties via electrically induced carrier accumulation. The planar structure of the absorber models presented facilitates simple thin-film fabrication. With judicious material selection and appropriate bias voltage, a spectral shift of 47 nm can be achieved within the visible range, thus producing a discernible color change.
Quantitative evaluation of myocardial layer-specific strain using two-dimensional speckle tracking echocardiography in septic patients
Authors: Zhang Jin , Zhu Jing , Xie Tian , Sun Fan , Wang Ni , Guo Feng-Mei 
Published: August 2023

Abstract
Background
Although global longitudinal strain (GLS) is proven to be reduced and associated with adverse outcomes in septic patients, it has not been elucidated whether or not layer-specific strains are reduced. We aimed to explore the layer-specific strains of left ventricular (LV) for assessing myocardial dysfunction in septic patients.

Methods
A prospective observational study of patients with sepsis was conducted in a tertiary hospital in China. Routine two-dimensional speckle tracking echocardiography was performed within 24 h of enrollment. Demographic data, laboratory values, and clinical outcomes were collected.

Results
We recruited 79 septic patients finally. The mean age of septic patients was 59.4 years old and 45 (57.0%) were male. The median Acute Physiology Age and Chronic Health Evaluation (APACHE II) score, and mean sequential organ failure assessment (SOFA) score of all patients were 19.0 and 7.7, respectively. According to the left ventricular ejection fraction (LVEF) value of 50%, the patients were categorized into two groups: SICM (sepsis-induced cardiomyopathy, LVEF < 50%, n = 22) and non-SICM group ( LVEF ≥ 50%, n = 57). The median LVEF of SICM and non-SICM patients were 41.9% and 58.7%, and SICM patients had less negative layer-specific strain and global strain than that of non-SICM patients. The echocardiographic comparison of non-SICM and healthy controls was conducted to explore the myocardial injuries of non-SICM patients and the non-SICM had worse LS-epi than that of controls (-18.5% vs. -21.4%, p = 0.024).

Conclusion
There were 72.2% (57) septic patients presented with non-SICM (LVEF ≥ 50%), and the strain value of epicardium of them was less negative than healthy controls.
Evaluation of predictive capability of Bayesian spatio-temporal models for Covid-19 spread
Authors: Lawson Andrew B. 
Published: August 2023

Abstract
Background
Bayesian models have been applied throughout the Covid-19 pandemic especially to model time series of case counts or deaths. Fewer examples exist of spatio-temporal modeling, even though the spatial spread of disease is a crucial factor in public health monitoring. The predictive capabilities of infectious disease models is also important.

Methods
In this study, the ability of Bayesian hierarchical models to recover different parts of the variation in disease counts is the focus. It is clear that different measures provide different views of behavior when models are fitted prospectively. Over a series of time horizons one step predictions have been generated and compared for different models (for case counts and death counts). These Bayesian SIR models were fitted using MCMC at 28 time horizons to mimic prospective prediction. A range of goodness of prediction measures were analyzed across the different time horizons.

Results
A particularly important result is that the peak intensity of case load is often under-estimated, while random spikes in case load can be mimicked using time dependent random effects. It is also clear that during the early wave of the pandemic simpler model forms are favored, but subsequently lagged spatial dependence models for cases are favored, even if the sophisticated models perform better overall.

Discussion
The models fitted mimic the situation where at a given time the history of the process is known but the future must be predicted based on the current evolution which has been observed. Using an overall ‘best’ model for prediction based on retrospective fitting of the complete pandemic waves is an assumption. However it is also clear that this case count model is well favored over other forms. During the first wave a simpler time series model predicts case counts better for counties than a spatially dependent one. The picture is more varied for morality.

Conclusions
From a predictive point of view it is clear that spatio-temporal models applied to county level Covid-19 data within the US vary in how well they fit over time and also how well they predict future events. At different times, SIR case count models and also mortality models with cumulative counts perform better in terms of prediction. A fundamental result is that predictive capability of models varies over time and using the same model could lead to poor predictive performance.
In addition it is clear that models addressing the spatial context for case counts (i.e. with lagged neighborhood terms) and cumulative case counts for mortality data are clearly better at modeling spatio-temporal data which is commonly available for the Covid-19 pandemic in different areas of the globe.