bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphism of vascular homeostasis genes as a risk factor for the formation of preeclampsia
Authors: Elykova A. V. , Orlova V. S , Batlutskaya I. V. , Sorokina I. N. , Efremova O. A. , Rudyh N. A. , Churnosov M. I. 
Published: April 2023

Introduction. Preeclampsia (PE) is a serious complication of pregnancy that occurs in 3-8% of pregnant women and is the leading cause of maternal and perinatal morbidity and mortality.Aim. To evaluate the role of vascular homeostasis gene polymorphism in the formation of preeclampsia.Materials and methods. The sample for this study included 250 women with preeclampsia and 209 women with normal gestation (control group). Five polymorphic loci of vascular homeostasis genes were selected for analysis: α-adducin (G460W ADD1), β2-adrenoceptor (+46G/A ADRB2), endothelin-1 (Lys198Asn EDN1) encoding the β3 G protein subunit (G/A GNB3), cytochrome 3A5 (+6986G/A CYP3A5). The molecular genetic study of all SNPs was carried out by polymerase chain reaction.Results. It was found that genetic variants determine the risk of developing preeclampsia. The allelic variant 198Lys EDN1 (84.80%) occurs in women with a clinical diagnosis of PE significantly more often than in women of the control group (79.67%) (p = 0.05; OR = 1.43; 95%CI 1.01–2.03). At the same time, among pregnant women without PE, combinations of 198Asn EDN1 x +46 A ADRB2 (23.65%) and 198Asn EDN1 x 460 ADD1 x +46 A ADRB2 (23.65%) are registered 1.6–1.7 times more often than among women with PE (14.46 and 13.65%, respectively, рperm = 0.032). Conclusion. The risk factor for the formation of preeclampsia is the 198Lys EDN1 allele (OR = 1.43), and combinations of genetic variants 198Asn EDN1 х +46 A ADRB2 (OR = 0.55) and 198Asn EDN1 х +46 A ADRB2 х 460G ADD1 (OR = 0.51) have a protective value.
Time series data and rainfall pattern subjected to climate change using non-parametric tests over a vulnerable region of Karnataka, India
Authors: Kumar Sanjay , Ahmed S. A. , Karkala Jyothika 
Published: April 2023

AbstractFluctuations in the precipitation pattern often tend to have an impact on the availability of water, making it necessary to explore spatiotemporal variations in rainfall. This study explores the time series analysis of the rainfall from 1952 to 2019. The trend was analyzed using the modified Mann–Kendall test (MMK), and innovative trend analysis (ITA). The analysis showed that the northern region received the least rainfall while the southern region received the maximum rainfall except that one of the stations had a positive kurtosis. The kurtosis of the rainfall histogram ranges from −0.69 to 24.13. The trend was very well defined by all the methods, though MMK z statistics showed more occurrences of significant changes in the rainfall. The northeast monsoon carried a significantly decreasing trend at Chikkanayakanahalli station where the z value of MMK and ITA_R test showed values of −1.33 and −2.23, respectively, while all of the significantly increasing trends were defined by the MMK test in the annual and southwest monsoon season. The homogeneity test showed the most correlation between Pettitt and Buishand tests in comparison to SNHT. Later, the ARIMA model was run for the precipitation to predict the rainfall value from 2019 to 2029.
Wastewater reuse and recycling of the steel industry in China: history, current situation, and future perspectives
Authors: Liang Siyi , Du Ye , Liu Qi , Li Jiankang , Liu Zhi , Xu Yan , Chen Zhuo , Wu Yin-Hu , Hu Hong-Ying 
Published: April 2023

Abstract

China is the largest steel producer in the world. Effective methods to alleviate the contradiction between water supply and water demand of the iron and steel industry in China are to implement the recycling of wastewater from the iron and steel industry and develop unconventional water resources. This paper reviews the development of wastewater recycling in the iron and steel industry in China in the past 40 years (1980–2020). During this period, steel output has increased from 36 to 1,053 million tons, freshwater consumption per ton of steel has decreased from 35.9 to 2.45 tons, and water resources reuse has soared from 61.2 to 98.02%. Four typical cases, including the Anyang Steel Group, the Tangshan Steel Group, the Tianjin Steel Group, and the Taihang Steel Group, were analyzed. In addition, a water efficiency research project of iron and steel enterprises in China was carried out in 2019. Statistical analyses on wastewater recycling rate, reuse rate, direct cooling water circulation rate, and other indicators were performed. The recycling of wastewater in the iron and steel industry would be continuously improved by policy drivers, economic drivers, and technical drivers.
An Assessment of How Clinicians and Staff Members Use a Diabetes Artificial Intelligence Prediction Tool: Mixed Methods Study
Authors: Liaw Winston R , Ramos Silva Yessenia , Soltero Erica G , Krist Alex , Stotts Angela L 
Published: April 2023

Background
Nearly one-third of patients with diabetes are poorly controlled (hemoglobin A1c≥9%). Identifying at-risk individuals and providing them with effective treatment is an important strategy for preventing poor control.

Objective
This study aims to assess how clinicians and staff members would use a clinical decision support tool based on artificial intelligence (AI) and identify factors that affect adoption.

Methods
This was a mixed methods study that combined semistructured interviews and surveys to assess the perceived usefulness and ease of use, intent to use, and factors affecting tool adoption. We recruited clinicians and staff members from practices that manage diabetes. During the interviews, participants reviewed a sample electronic health record alert and were informed that the tool uses AI to identify those at high risk for poor control. Participants discussed how they would use the tool, whether it would contribute to care, and the factors affecting its implementation. In a survey, participants reported their demographics; rank-ordered factors influencing the adoption of the tool; and reported their perception of the tool’s usefulness as well as their intent to use, ease of use, and organizational support for use. Qualitative data were analyzed using a thematic content analysis approach. We used descriptive statistics to report demographics and analyze the findings of the survey.

Results
In total, 22 individuals participated in the study. Two-thirds (14/22, 63%) of respondents were physicians. Overall, 36% (8/22) of respondents worked in academic health centers, whereas 27% (6/22) of respondents worked in federally qualified health centers. The interviews identified several themes: this tool has the potential to be useful because it provides information that is not currently available and can make care more efficient and effective; clinicians and staff members were concerned about how the tool affects patient-oriented outcomes and clinical workflows; adoption of the tool is dependent on its validation, transparency, actionability, and design and could be increased with changes to the interface and usability; and implementation would require buy-in and need to be tailored to the demands and resources of clinics and communities. Survey findings supported these themes, as 77% (17/22) of participants somewhat, moderately, or strongly agreed that they would use the tool, whereas these figures were 82% (18/22) for usefulness, 82% (18/22) for ease of use, and 68% (15/22) for clinic support. The 2 highest ranked factors affecting adoption were whether the tool improves health and the accuracy of the tool.

Conclusions
Most participants found the tool to be easy to use and useful, although they had concerns about alert fatigue, bias, and transparency. These data will be used to enhance the design of an AI tool.
Deoxysphingolipids – atypical skeletal muscle lipids related to insulin resistance in humans that decrease insulin sensitivity in vitro
Authors: Zarini Simona , A. Zemski Berry Karin , E. Kahn Darcy , Garfield Amanda , Perreault Leigh , Kerege Anna , C. Bergman Bryan 
Published: April 2023

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<p>Sphingolipids are thought to promote skeletal muscle insulin resistance. 1-Deoxysphingolipids (dSL) are atypical sphingolipids that are increased in plasma of individuals with type 2 diabetes and cause β-cell dysfunction <em>in vitro</em>. However, their role in human skeletal muscle in unknown. We found that dSL species are significantly elevated in muscle of individuals with obesity and type 2 diabetes compared to athletes and lean individuals and are inversely related to insulin sensitivity. Furthermore, we observed a significant reduction in muscle dSL content in individuals with obesity who completed a combined weight loss and exercise intervention. Increased dSL content in primary human myotubes caused a decrease in insulin sensitivity associated with increased inflammation, decreased AMP-activated kinase (AMPK) phosphorylation, and altered insulin signaling. Our findings reveal a central role for dSL in human muscle insulin resistance and suggest dSL as therapeutic targets for the treatment and prevention of type 2 diabetes.</p>
PROJETO BLOCO MANIFOLD 15 MIL psi
Authors: Mattos Christian Ferreira , BORN RENATA MERCANTE 
Published: April 2023

Sistemas hidráulicos são amplamente utilizados nos meios industriais e, sendo assim, estão sempre em processo de evolução. O Bloco Manifold é uma ideia já usada há algum tempo em engenharia aeronáutica e submarina para acionamento de válvulas solenoides e servo válvulas. É um produto constituído por um bloco retangular que atua como um distribuidor de pressão facilitando o fluxo de fluidos e interligando as saídas internas permitindo uma operação eficiente do sistema. Esse bloco é de modo geral utilizado para substituir um grande número de válvulas, tubos, mangueiras e ligações na montagem de uma unidade hidráulica, por isso, é eficaz para economizar espaço e baixar custo das instalações, além disso, esse produto apresenta outros benefícios como um melhor aproveitamento do sistema hidráulico uma vez que, a instalação é feita de modo extremamente simples e a manutenção e a substituição de válvulas podem ser realizadas de forma rápida. Outra característica importante é a redução de vazamentos no circuito. É proposto um projeto de um Manifold com vedação metal-metal (cone rosca) para tubo de 9/16’’ e rosca 13/16’’- 16 UNF, com apenas uma entrada de pressão e nove saídas para pressão máxima de 15000 psi. Para atingir este objetivo, a proposta utiliza, dois modelos de cálculo com base no conceito de Lamé e ASME B1.1 Machinery Handbook, além de fazer uso de ferramentas de cálculo de elementos finitos. Nesse método, os resultados são diretamente separados em tensões de membrana e de flexão e são classificados em tensões primárias e secundárias. Tais análises têm sido conduzidas em vários trabalhos de pesquisas e este trabalho se inclui nessa tarefa.
The impact of COVID-19 pandemic on cybersecurity in electronic banking in Poland
Authors: Macierzyński Wiesław Łukasz , Boczoń Wojciech 
Published: April 2023

Purpose: The purpose of the article is to present both theoretical and practical basis for cybersecurity in electronic banking in Poland during the COVID-19 pandemic. During this period a major reorganisation of IT solutions occurred, which allowed to extend the range of online products and services offered both to bank customers and employees. As our life is more and more dependent on digital technologies, cyber attacks have become more costly and more dangerous. Driven by dynamic technological development regulations have changed, which resulted in cybersecurity becoming a key priority in financial institutions. All the more so because the rapid technological development has been followed by more and more advanced techniques used by criminals searching for easy financial profits. Methodology: The paper uses the method of literature review - mostly electronic sources, descriptive and comparative analyses. Findings: From customers, perspective, the impact of COVID-19 pandemic on cybersecurity in electronic banking in Poland may be recognized as negative. The years 2020-2021 brought a dynamic growth in the number of digital banking customers, especially mobile banking. In those years financial institutions recorded an enormous increase in online payments, which was the result of strong, forced by the pandemic, surge in sales in E-commerce. At the same time, there was a sharp rise in the crime rate targeted at banks, but most of all, at bank customers. While the security of the very financial institutions remained unthreatened, there was an explosion in the number of cybercrimes targeted at E-banking users, with the losses giving dozens of millions PLN in total. That is reflected by the data provided by the National Bank of Poland, numerous complaints to the Financial Ombudsman, the Office of Competition and Consumer Protection, as well as the police investigations. Practical implications: The analysis of relations between theoretical and practical bases of cybersecurity in E-banking in Poland during the COVID-19 pandemic is a key factor for financial institutions. Cybercrime undermines customers' trust in E-channels and therefore negatively influences how banks are perceived, the level of the users' activity in digital channels, and consequently, activity and sales in E-channels. Besides the image and financial risks, banks need to take into consideration the increase in reputation, operation and legal risks. On these grounds, it is possible for state organisations and financial institutions to develop professional education concerning cybersecurity, not only for E-banking customers, but for the whole society.
Volumetric Absorptive Microsampling Technique in the LC-MS Determination of Direct Oral Anticoagulants
Authors: Nela Zidekova , Kristian Prso , Lucia Babalova , Stefan Sivak , Egon Kurca , Juraj Mokry , Vladimir Nosal , Martin Kertys 
Published: April 2023

Abstract
Direct oral anticoagulants represent a significant group of drugs used in the prevention or treatment of venous thromboembolic events and stroke in patients with atrial fibrillation. Although routine therapy monitoring is not required, there is an increasing evidence that plasma levels may vary between individuals, suggesting the benefit of plasma levels measurement in some situations. Therapeutic drug monitoring is becoming more popular and accessible to the broader population. Introducing microsampling techniques for the quantitative collection of blood samples has arisen nowadays. The volumetric absorptive microsampling approach using a commercially available device such as a Mitra stick overcomes the hematocrit effect present in the dry blood spot technique. This review discusses the possible application of the volumetric absorptive microsampling approach in monitoring direct oral anticoagulant therapy efficacy.
A road not taken? Economic ideology and the articulation of policy alternatives in Irish state economic policymaking, 1948–58
Authors: Fitzgerald Frank 
Published: April 2023

Abstract
In the midst of a seemingly unending economic crisis, the period 1948–58 saw a dramatic expansion of fiscal policy in Ireland. T. K. Whitaker’s Economic Development is traditionally represented as a landmark departure behind this change from traditional Department of Finance thinking and political inertia, propelled by the perceived Keynesian ideas of his fellow younger economists. However, by assessing the policy positions each actor adopted during major economic events of the period, this study argues that Whitaker’s economic outlook largely aligned with Finance’s, and that Economic Development must be viewed in large part as a reaction to the pre-existing fiscal commitments of the public capital programme. In tandem, it concludes that although the influential younger economists of the period are sometimes described as expansionist Keynesians – such as Patrick Lynch, who in the early part of the decade spearheaded Keynesian-type initiatives such as the capital budget principle – by mid decade their views aligned with the more classical economic outlook of the Department of Finance.
Regional governance and regional development: Implications of the Action Programme for Effective Local Government
Authors: Breathnach Proinnsias 
Published: April 2023

Abstract
Since the 1980s, regional development policy in advanced economies has emphasised the promotion of endogenous development potentials within regions, with local/regional government playing a leading role in the creation of effective governance structures for mobilising these potentials. A key feature of this approach is the adoption of the city-region as the organising unit for pursuing local/regional development. Ireland has not followed this lead, continuing to rely on external investment as the main engine of economic growth and failing to devolve highly centralised functions which could give local/regional government a more effective developmental role. This article argues that the 2012 Action Programme for Effective Local Government proposes a regional structure which is meaningless in terms of city-region development and fails to address the governance weaknesses which inhibit development at the regional and local levels. The action programme therefore ignores international best practice regarding how effective regional development should be pursued.
Phytochemical, Proximate and in-vivo hypoglycemic Potential of Synsepalum dulcificum for Management of Diabetes mellitus in Nigeria
Authors: Onuminya Temitope O. , Asekunowo Anita K. , Ifelaja Folakemi M. , Ogundipe Oluwatoyin T. 
Published: April 2023

Abstract

Synsepalum dulcificum, a potent natural sweetener, is notably used in the traditional treatment of Diabetes mellitus in Nigeria though scientific explanation for its use is not well known. In this study, the phytochemical, proximate and hypoglycemic potential of the leaf and stem extracts (ethanol and aqueous) of S. dulcificum were investigated. The phytochemical and proximate analysis were carried out using a standard protocol. In-vivo assay protocols on alloxan-induced diabetic albino rats was followed in determining the hypoglycemic potentials of the extracts (concentrations: 100 mg/Kg, 200 mg/Kg, 400 mg/Kg), using glibenclamide as a standard drug. The aqueous leaf extract gave a higher yield (19.67%) compared to ethanolic extract (17.15%). Phytochemical analysis revealed the presence of flavonoids, saponins, terpenoids, tannins, phenols, steroids, cardiac glycosides and alkaloids in varying degrees in the plant’s parts. Proximate analysis showed higher lipid (23.30%) and protein (12.94%) in leaves and higher fibre content in stems (30.00%). The aqueous leaf extract at a high dose (400 mg/kg) gave the best glucose lowering effect (66.67 mg/dL) compared to the medium dose (78.33 mg/dL) and the standard drug (70.00 mg/dL). The albino rats were unable to survive at the lower dose (100 mg/kg) of all the extracts. The observed hypoglycemic effect of the aqueous leaf extract may be linked to significant tannins, flavonoids and saponins in the extract, as these phytochemicals have been reported to exhibit blood sugar lowering potentials. The results from this study confirmed that the leaf aqueous extract as a potential anti-diabetic agent and justified the folkloric use of Synsepalum dulcificum in the management of diabetes mellitus in Nigeria.
Mn(II), Fe(III) and Ni (II) Complexes of Mixed Citric acid - Sulphamethoxazole: Synthesis, Characterization and Antibacterial activity
Authors: Lawal Amudat , Olowude Seyi , Rajee Abdullahi O. , Elaigwu Sunday E. , Bamigboye Mercy O. , Saadu Haizat O. , Mamman Amos , Babamale Halimat F. , Yunus-Issa Muslimat T. , Amolegbe Saliu A. 
Published: April 2023

Abstract
Three mixed ligand complexes of sulphamethoxazole and citric acid have been synthesized using Mn(II), Fe(III) and Ni(II) chlorides. The complexes were characterized by elemental analysis, melting point, conductivity test, magnetic measurement, UV-Visible and infrared spectroscopy. The infrared spectra data revealed that the ligands act as bidentate, in which citric acid coordinate through C=O of the carboxyl and oxygen of the hydroxyl groups, while sulphamethoxazole coordinates through nitrogen atom of the primary amine group and O=S=O of the sulphonyl group. The result of the elemental analysis was consistent with the proposed pattern for the complexes, while the melting point determination confirmed that the synthesized compounds were pure. Antibacterial activity of metal complexes were screening against five strain bacteria microorganism of g(+)Pseudomonas aeruginosa, Eschericia coli, g(+)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The result showed that the overall zone of inhibition against bacterial isolate follows an increasing order of priority Fe(III)˃ Ni(II)˃ Mn(II) complexes.
The role of speed-based strategy instruction on learning and transfer of motor sequences in a complex task
Authors: Iranmanesh Hesam , Kakhki Alireza Saberi , Taheri Hamidreza , Abadi Abolfazl Shayan Noosh 
Published: April 2023

Abstract

Study aim: The purpose of this study was to investigate the impact of speed-based strategy instruction on motor sequence learning and transfer.

Material and methods: Male participants (n = 30, 18 to 24 years old) were assigned to one of the groups based on instruction. Motor sequence learning was examined using the complex dynamic arm movement task. Two sets of speed and control instructions completed ten blocks of 100 trials in the acquisition phase followed by the retention and transfer test after 24 hours.

Results: Mixed analysis of variance (2×10 and 2×4) and the independent samples t-test were used to examine the data. The results demonstrated that element response time and error of prediction in both groups were significantly improved in the acquisition phase (P < 0.05), but in the 24-hour retention test, the speed group had a significantly better element response time than the control group (P < 0.05). Furthermore, the findings of the independent samples t-test in the transfer test revealed that element duration and error rate were significantly better in the speed group than the control group (P < 0.05).

Conclusions: According to the data, when compared to the conventional technique, in which participants were not given any special instructions, the speed-based instruction resulted in greater acquisition of the acquired motor sequence and better transfer of a new sequence.