bluuebunny/crossref_metadata_2025_split huggingface dataset:
A challenging diagnosis of mammary analogue secretory carcinoma (MASC) on fine needle aspiration cytology and cell block: A cytopathologist's perspective
Authors: Saraf Pallavi , Bharti Jyotsna Naresh , Malik Abhishek 
Published: February 2023

AbstractMammary analogue secretory carcinoma (MASC) is a recently described salivary gland carcinoma that resembles the secretory carcinoma of the breast and is characterised by t(12;15) (q13;q25) translocation, which results in an ETV6‐NTRK3 gene fusion product. On cytomorphology, it is characterised by papillary fragments, clusters, and singly dispersed tumour cells. These tumour cells are large and have abundant vacuolated cytoplasm. Acinic cell carcinoma of the salivary gland is the most common differential diagnosis of MASC. Other differentials include mucoepidermoid carcinoma, salivary duct carcinoma, pleomorphic adenoma, and oncocytic salivary gland neoplasms. Immunohistochemistry and morphology are critical in establishing the correct diagnosis. We present a case of a 46‐year‐old male patient diagnosed as MASC of the parotid gland on fine needle aspiration cytology and cell block.
Up‐front autologous hematopoietic stem cell transplantation after first complete remission improved prognosis of advanced extra‐nodal NKT cell lymphoma: A multicenter real‐world study in China
Authors: Gao Honghao , Lin Ningjing , Gu Zhenyang , Zhao Shihua , Wang Xiaopei , Yuan Shunzong , Song Yuqin , Zhu Jun , Huang Wenrong , Liu Weiping , Gao Chunji 
Published: February 2023

AbstractObjectivesThe advanced extra‐nodal NK/T‐cell lymphoma (ENKTL) is highly aggressive and lacks effective treatment with a poor prognosis. This study aimed to investigate the effectiveness and safety of autologous hematopoietic stem cell transplantation (ASCT) in CR1.MethodsForty of 121 patients with advanced ENKTL from four Chinese hospitals between January 2006 to December 2021 who achieved first complete remission (CR1) and received at least 4 cycles chemotherapy, were enrolled for analysis. Twenty patients received ASCT as up‐front consolidation therapy (Group A), and 20 patients only received chemotherapy (Group B). Clinical features, treatment and follow‐up information were collected.ResultsWith a median follow‐up of 27 months (range, 4–188 months), the 2‐year overall survival (OS) in Group A, 61% (95% CI 37%–85%), was better than that in Group B, 26% (95% CI 2%–50%), p = .018. The 2‐year progression‐free survival (PFS) was 56% (95% CI 32%–80%) in Group A, 26% (95% CI 2%–50%) in Group B, p = .026. III–IV grade hematological toxicity was the most common adverse event. No treatment‐related deaths were observed in both groups.ConclusionUp‐front ASCT could improve survival of advanced ENKTL patients in first complete remission, but need be confirmed by a prospective clinical trial.
Clinical utility of targeted next‐generation sequencing panel in routine diagnosis of hereditary hemolytic anemia: A national reference laboratory experience
Authors: Agarwal Archana M. , McMurty Valarie , Clayton Adam L. , Bolia Ashini , Reading N. Scott , Mani Coumarane , Patel Jay L. , Rets Anton 
Published: February 2023

AbstractIntroductionHereditary hemolytic anemias (HHA) comprise a heterogeneous group of disorders resulting from defective red blood cell (RBC) cytoskeleton, RBC enzyme deficiencies, and hemoglobin (Hb) synthesis disorders such as thalassemia or sideroblastic anemia.Materials and MethodsOur hemolytic anemia diagnostic next‐generation sequencing (NGS) panel includes 28 genes encoding RBC cytoskeletal proteins, membrane transporter, RBC enzymes, and certain bilirubin metabolism genes. The panel covers the complete coding region of these genes, splice junctions, and, wherever appropriate, deep intronic or regulatory regions are also included. Four hundred fifty‐six patients with unexplained hemolytic anemia were evaluated using our NGS panel between 2015 and 2019.ResultsWe identified pathogenic/likely pathogenic variants in 111/456 (24%) patients that were responsible for the disease phenotype (e.g., moderate to severe hemolytic anemia and hyperbilirubinemia). Approximately 40% of the mutations were novel. As expected, 45/456 (10%) patients were homozygous for the promoter polymorphism in the UGT1A1 gene, A(TA)7TAA (UGT1A1*28). 8/45 homozygous UGT1A1*28 cases were associated with additional pathogenic mutations causing hemolytic anemia, likely exacerbating hyperbilirubinemia. The most common mutated genes were membrane cytoskeleton genes SPTA1, and SPTB, followed by PKLR. Complex interactions between SPTA1 low expression alleles, alpha‐LELY and alpha‐LEPRA alleles, and intragenic SPTA1 variants were associated with hereditary pyropoikilocytosis and autosomal recessive hereditary spherocytosis in 23/111 patients.ConclusionsOur results demonstrate that hemolytic anemia is underscored by complex molecular interactions of previously known and novel mutations in RBC cytoskeleton/enzyme genes, and therefore, NGS should be considered in all patients with clinically unexplained hemolytic anemia and in neonates with hyperbilirubinemia. Moreover, low expression alleles alpha‐LELY and alpha‐LEPRA should be included in all targeted HHA panels.
RETRACTED: The design of intelligent fuzzy cognitive system of music emotion by product supply chain management
Authors: Li Fanfan , Jiang Rong , Li Jiabao 
Published: February 2023

AbstractThe classification of musical emotion is a challenging problem due to the subjectivity of human perception. In order to analyse the emotion contained in music from the perspective of product supply chain management, the psychological model and characteristics of music emotion are introduced. Additionally, the current product supply chain and the composition of the two contracts are analysed based on the characteristics of online music products. Finally, a speech emotion recognition model based on a Fuzzy Cognitive Map (FCM) is proposed. Two corpora containing five emotions (sadness, anger, happiness, surprise, and boredom) are selected to test the performance and characteristics of the network. In order to evaluate the system performance, different acoustic features are extracted, including prosodic features, formant features, marginal spectral features, and Mel‐Frequency Cepstral Coefficients (MFCC). The results show that the average recognition rate of MFCC features on the Berlin emotional speech database is 70.36%, which is 0.75% higher than the second‐highest edge spectrum features and achieves better results. Meanwhile, on this database, the Musical Emotion Recognition System based on FCM (MERS‐FCM) is improved by 20.36%, 7.34%, and 4.12% compared with Back Propagation, K‐nearest neighbour, and support vector machine, respectively, which shows that MERS‐FCM has better performance. The research of the music emotion recognition system based on FCM can provide more reference paths for the use and development of music emotion information.
A functional trait framework for integrating nitrogen‐fixing cover crops into short‐rotation woody crop systems
Authors: Ferreira Gabriel W. D. , Aubrey Doug P. 
Published: February 2023

AbstractDeveloping approaches to simultaneously maximize short‐rotation woody crop (SRWC) productivity while minimizing footprints associated with intensive management is imperative to profitable and sustainable bioenergy production systems. Intercropping nitrogen (N)‐fixing cover crops in SRWC systems is an overlooked approach to sustainably intensify SRWC production by increasing N availability using less environmentally costly inputs. Here, we discuss how functional traits (e.g., seasonal activity, lifespan, leaf habit, soil exploration) of cover crops and SRWCs may interact through space and time influencing access to light, water, and nutrients to provide a framework for successful integration of cover crops into SRWCs. Next, we summarize the literature on intercropping forest plantations with N‐fixing cover crops to identity research gaps and outline future research needs and opportunities. And then, using empirical N demand and productivity data from SRWCs and cover crop N inputs from the literature, we illustrate how SRWC leaf habit (conifer evergreens and deciduous hardwoods) would influence successful integration of cover crops and potential N fixation. We estimate that integrating cover crops into SRWCs could supply 27% and 72% of the N demand across a 10‐year rotation for an evergreen and a deciduous hardwood, respectively. These figures suggest theseintegratedSRWC systems may approach a virtual minimal external N input when other biogeochemical cycles are considered. The guiding principles presented here are grounded in ecological theory and provide a framework for sustainable intensification of forest production.
Efficacy of a novel remotely‐generated ultrasonic root canal irrigation system for removing biofilm‐mimicking hydrogel from a simulated isthmus model
Authors: Park Eun Hyun , Park Ryeol , Seo Jaedeok , Kim Wonjung , Kim Ho‐Young , Shon Won‐Jun 
Published: February 2023

AbstractAimTo evaluate the efficacy of a novel ultrasonic irrigation device, remotely‐generated irrigation with a non‐invasive sound field enhancement (RINSE) system, in removing biofilm‐mimicking hydrogel from a simulated isthmus model and compare it with sonically‐ and ultrasonically‐activated irrigation systems.MethodologyA polycarbonate root canal model containing two standardized root canals (apical diameter of 0.20 mm, 4% taper, 18 mm long with a coronal reservoir) connected by three isthmuses (0.40 mm deep, 2 mm high, 4 mm long) was used as the test model. The isthmuses were filled with a hydroxyapatite powder‐containing hydrogel. The canals were filled with irrigant, and the models were randomly assigned to the following activation groups (n = 15): EndoActivator (EA), ultrasonically activated irrigation (UAI), and RINSE system (RS). Syringe irrigation (SI) with a 30G needle served as the control. Standardized images of the isthmuses were taken before and after irrigation, and the amount of hydrogel removed was determined using image analysis software and compared across groups using anova (p < .05).ResultsHydrogel removal was significantly higher with the RS (83.7%) than with UAI, EA, or SI (p ≤ .01). UAI (69.2%) removed significantly more hydrogel than SI and EA (p < .05), while there was no significant difference between SI (24.3%) and EA (25.7%) (p = .978).ConclusionsRINSE system resulted in the most hydrogel removal, performing better than UAI or EA. The effect of RS was also not reliant on the insert or tip entering the pulp chamber or root canal, making it particularly useful in conservative endodontics.
Is oxidative stress involved in the hepatic inflammatory response to apical periodontitis? A comparative study in normal and hyperlipidaemic rat
Authors: Xiao Suli , Lei Huaxiang , Li Pingping , Ma Dianfu , Chen Shuai , Huang Xiaojing 
Published: February 2023

AbstractAimThe aim of the study was to explore the involvement of oxidative stress (OS) in the hepatic inflammation induced by apical periodontitis (AP). Periapical, systemic and hepatic reaction to AP under hyperlipidaemia was also investigated.MethodologyA total of 16 male Sprague–Dawley rats were fed with a hyperlipidaemic diet (HD) whereas another 16 rats with a normal diet (ND). After 9 weeks, the first molars of the right maxilla and mandible of 8 HD and 8 ND rats were exposed to induce AP (ND, ND + AP, HD and HD + AP group). After 5 weeks, rats were euthanized, the haematological tissue was collected directly from the heart, and serum levels of inflammatory cytokines were measured. Liver tissue was analysed by haematoxylin–eosin and Masson staining, and reverse transcription–polymerase chain reaction (RT‐PCR) was performed to detect mRNA expression of inflammatory cytokines. Serum, periapical, and hepatic OS parameters including total oxidant status (TOS), total antioxidant capacity (TAOC) and oxidative stress index (OSI) were measured by enzyme‐linked immunosorbent assay (ELISA). The area of AP lesion in the right maxilla or mandible was radiographically assessed. Student's t‐test was performed on the periapical data. A one‐way analysis of variance and the Kruskal–Wallis test were analysed for others.ResultsThe HD + AP group had a larger AP lesion in the maxilla, compared with the ND + AP group (p < .05). The ND + AP group presented higher serum interleukin (IL)‐18, IL‐1β, TOS, OSI levels, lower serum TOAC levels, higher hepatic tumour necrosis factor (TNF)‐α mRNA expression and higher hepatic TOS, and OSI levels, compared with the ND group (p < .05). The HD + AP group had lower serum IL‐4 level, higher serum IL‐1β level, and higher hepatic IL‐6 and transforming growth factor (TGF) ‐β1 mRNA expression, compared with the HD group (p < .05).ConclusionsApical periodontitis could activate systemic and liver inflammation by promoting serum IL‐18, 1L‐1β, TOS and OSI expression, enhancing hepatic TOS and OSI expression and inhibiting serum TOAC expression. AP under hyperlipidaemia led to more profound periapical bone destruction in the maxilla and elicit systemic and liver inflammatory responses through elevating serum levels of IL‐1β, descending serum IL‐4 level and improving hepatic IL‐6 and TGF‐β1 expression.
Curcumin‐containing microencapsulated antioxidant composite paper for cake preservation
Authors: Bian Jiayi , Cai Hong , Hu Wenqing , Liu Zhuolin , Zhang Zhikun , Sun Huangxin , Li Dan , Zhu Weizhong , Li Li 
Published: February 2023

SummaryThe cost‐effective strategy of using paper‐based materials as alternatives to plastics can aid in reducing environmental stress. Herein, a novel green low‐carbon paper‐based food‐packaging composite was synthesised: curcumin microcapsule‐polyvinyl alcohol/beeswax/chitosan (CURM‐PVA/BW/CS) composite papers. Scanning electron microscopy and X‐ray diffraction results confirmed that curcumin was successfully encased and adhered to the paper. The water vapour permeability and oxygen transmission rate of the composite papers were 42.28 g (m2·d)−1 and 3.41 cm3 (m2·d·atm)−1, respectively. The antioxidant capacity of paper was 93.53%, and the mechanical properties were effectively improved by adding natural antioxidants to the coating. Finally, cakes were packaged in the biodegradable 1%CURM‐PVA/BW/CS papers exhibited optimal preservation during the storage period, based on the characterisation of the cake peroxide value, acid value and microbiological count. Overall, the CURM‐PVA/BW/CS paper showed great potential for food packaging.
Effect of exogenous GABA combined with ultrasound treatment on the physicochemical and functional properties of sprouted mung bean starch
Authors: Lang Shuangjing , Gao Fei , Li Xiaoqiang , Sui Chunguang , Wang Feifei , Wang Lidong , Zhang Hongwei 
Published: February 2023

SummaryStarch is the major nutrient fraction in mung beans, wherein any physicochemical change in them while in germination as pre‐processing tactics influences their properties and hence application broadness. This study aimed to investigate the effect of ultrasonic synergistic exogenous GABA (γ‐aminobutyric acid) treatment on to the physicochemical and functional properties of mung bean starch during germination. At 96 h of germination, the total starch content was decreased to 21.18% and the amylose and resistant starch contents were 48.29% and 64.39% respectively. The particle size, colour, and water‐holding capacity of germinated mung bean starch were reduced significantly. As the increase in germination time continued, solubility, swelling and transparency increased and then decreased. The estimation of glycaemic index shows a minimum value of 22.52 at 12 h of germination. Combined treatment germination decreased the total starch content and increased the amylose and resistant starch content. The physicochemical properties of mung bean starch were significantly altered. Germination by ultrasound and exogenous GABA (γ‐aminobutyric acid) treatment modifies the functional properties of mung bean starch and provides a theoretical basis for its application in food.
Effect of two starters (Jiu Yao) on Chinese rice wine microbial community and flavour
Authors: Tian Shufang , Li Yanbin , Li Yudong , Du Guocheng 
Published: February 2023

SummaryThe starters (Jiu Yao) play key roles in the fermentation of rice wine. However, the microbial composition in the starters and their impact on the dynamic changes in the microbial community during the fermentation of Chinese rice wine (CRW) remain unknown. This study aimed to investigate the microbial community structure in different stages of CRW fermentation with two starters (Q1 and Q2) using high‐throughput sequencing approaches. The β‐diversity analysis showed significant differences in fungal components during fermentation, but no significant differences in bacterial composition. Saccharomyces, Aspergillus, Wickerhamomyces and Hyphopichia were the dominant fungal genera. Pediococcus and Weissella were the main bacterial genera. In addition, the ethanol content of wine fermented with Q1 starter (13.33%) is not as high as that of wine made with Q2 starter (14.57%). The total sugar concentration of Q1 and Q2 starters fermentation broth (HJ‐1 and HJ‐2) is 22.74 and 30.20 g L−1, respectively. The correlation analysis showed 11 dominant microbial genera are strongly related to 27 volatile compounds in HJ‐1, and seven dominant microbial genera are strongly related to 18 volatile compounds in HJ‐2. In conclusion, this study indicated that CRW brewed with different starters have different flavour profiles.
Mediators of the association between childhood body mass index and educational attainment: Analysis of a UK prospective cohort study
Authors: Bowman Kirsty , Cadman Tim , Goncalves Soares Ana , Robinson Oliver , Hughes Amanda , Heron Jon , Segal Alexa Blair , Huerta Maria Carmen , Howe Laura D. 
Published: February 2023

SummaryBackgroundHigher body mass index (BMI) in childhood is associated with lower academic achievement.ObjectiveTo explore potential pathways linking childhood BMI with educational attainment.MethodsUsing data from the Avon Longitudinal Study of Parents and Children prospective cohort study (N = 6949), we assessed the association between BMI z‐scores at 11.7 years and educational attainment at 16 (General Certificate of Secondary Education [GCSE] results). Depressive symptoms, externalizing behaviours, bullying and school enjoyment were considered as potential mediators. Mediators were examined individually and jointly using sequential causal mediation.ResultsHigher BMI z‐scores were associated with lower GCSE scores (females β = −3.47 95% CI −5.54, −1.41 males β = −4.33 95% CI −6.73, −1.94). Together, bullying, externalizing symptoms, depressive symptoms and school enjoyment mediated 41.9% of this association in females, and 23.3% in males. In males, evidence for mediation was weak (confidence intervals for all indirect effects spanned the null). In both females and males, most of the mediation was driven by externalizing symptoms.ConclusionsThe detrimental effect of higher BMI on educational attainment appears to be partly explained by externalizing behaviours, particularly in females. Interventions to support behavioural problems may help the academic achievement of children with a higher body weight.
Grupos de interés locales como factores de transformación de la mejora económica en mejora social en las empresas textiles y de confección de Etiopía
Authors: MULUBIRAN Telaye Fikadu , KARLSEN Asbjørn 
Published: February 2023

ResumenLos autores examinan los vínculos entre mejora económica y social en un país en desarrollo con una estricta legislación laboral y una política industrial ambiciosa, atendiendo a las estrategias de las empresas locales que participan en las redes mundiales de producción. A partir del análisis casuístico de cinco empresas textiles y de la confección de Etiopía realizado en 2015, observan que la seguridad del empleo y el bienestar físico no son resultado de las políticas de los compradores mundiales, sino de la legislación laboral negociada por empleadores, trabajadores y sindicatos, y concluyen que la mejora y el empeoramiento social pueden producirse simultáneamente en una misma empresa.
Schizophrenia and type 2 diabetes: Perceptions and understandings of illness management in everyday life
Authors: Rønne Sabrina Trappaud , Joensen Lene Eide , Zabell Vicki , Arnfred Sidse Marie , Brown Jennifer Valeska Elli , Jørgensen Rikke 
Published: February 2023

AbstractPeople with schizophrenia and type 2 diabetes face complex challenges in daily life and the management of both illnesses is burdensome. This qualitative interview study aimed to explore perceptions and understandings of the day‐to‐day management of schizophrenia and type 2 diabetes. Fourteen semi‐structured interviews were conducted between January 2020 and October 2021 in the participants' respective mental health clinics, in their homes or by phone. Thematic analysis led to four themes representing participants' self‐management strategies and perceived challenges. The first theme showed that participants use self‐learned strategies for managing schizophrenia. In contrast, they perceived type 2 diabetes self‐management as governed by a set of rules and guidelines given by health professionals. The second theme showed that both psychotic and negative symptoms present challenges to diabetes management. Theme 3 illustrated that participants consider their type 2 diabetes to be a very serious illness. They worried about potential long‐term consequences and expressed wishes and motivation to improve their lifestyle. The final theme showed that participants discuss challenges related to their schizophrenia with family and friends but not type 2 diabetes. In conclusion, this study highlights the importance of considering individual challenges and everyday routines when supporting this population. It underlines the need for future research to further explore the complexity of managing the illnesses and to understand the needs for treatment and support.
Second‐harmonic generation and structural rearrangements in multicomponent antimonite glasses by electrothermal poling
Authors: Topper Brian , Tagiara Nagia S. , Palles Dimitrios , Lind Felix , Baazouzi Mourad , Soltani Mohamed Toufik , Wondraczek Lothar , Möncke Doris , Kamitsos Efstratios I. 
Published: February 2023

AbstractElectrothermal poling is shown here to effectively induce second‐order nonlinear effects in heavy‐metal oxide antimonite glasses. In M2O–PbO–WO3–Sb2O3 (M = Li, Na, K) glasses, the poling‐induced second‐harmonic generation intensity is five times larger than in silica (Infrasil) for M = Na, twice as large as in silica for M = Li, and smaller than in silica for M = K. X‐ray photoelectron spectroscopy suggests that antimony ions exist predominantly in the trivalent oxidation state in the studied glass samples. Raman and infrared spectroscopy confirm that the glass network is comprised of SbO3, WO4, WO6, and PbO4 units—with some SiO4 moieties due to leaching from the silica crucible. The WO4 units appear to exist in two distinct sites, as evidenced by comparison of the vibrational spectra of alkali–tungsten–antimonite glasses with those of previously reported crystalline tungstate phases. The alkali type influences the equilibrium between tetrahedral tungstate anions, [WO4]2−, and the isomeric partially polymerized octahedral tungstate units, [WØ4O2]2− (Ø denotes a bridging oxygen). Raman spectroscopy line scans were used to track near‐surface structural changes on the anode side of poled glasses. They reveal that the tungstate equilibrium is also affected by poling. At the anode side, the population of partially polymerized [WØ4O2]2− species increases at the expense of anionic [WO4]2− species. This yields a net increase in the average bond length of the network forming constituents, which is commensurate with poling‐induced structural changes observed in other systems experimentally and computationally.