bluuebunny/crossref_metadata_2025_split huggingface dataset:
Borneo Vortices in a warmer climate
Authors: Liang Ju , Catto Jennifer L. , Hawcroft Matthew K. , Tan Mou Leong , Hodges Kevin I. , Haywood James M. 
Published: January 2023

AbstractBorneo Vortices (BVs) are weather systems that are responsible for devastating hydro-climatic extremes and significant losses of life and property in Southeast Asia. The typical resolution of most current climate models is insufficient to resolve these high-impact, synoptic-scale weather systems. Here, an ensemble of high-resolution models projects that future BVs may become less frequent and more stationary, driven by the weakening of the Northeast monsoon flow and associated cold surges across North Borneo. However, substantial increases in both the intensity and the total amount of precipitation from BVs are projected. Such changes are driven by the more humid and convectively unstable lower troposphere. As a result, the contribution of BVs to the accumulation of both total precipitation and extreme precipitation is projected to increase considerably in the vicinity of the southern South China Sea, making individual BVs more threatening to the adjacent coastal regions.
Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
Authors: Udden S. M. Nashir , Baek GuemHee , Pandey Kamal , Vidal Chantal , Liu Yulun , Rahimi Asal S. , Kim D. Nathan , Nwachukwu Chika R. , Mani Ram S. , Alluri Prasanna G. 
Published: January 2023

AbstractTargeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.
The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA
Authors: Yao Luxia , Wang Yihan , Qin Shenlu , Zhu Shihao , Wu Lianfeng 
Published: January 2023

AbstractYears of use of the antidiabetic drug metformin has long been associated with the risk of vitamin B12 (B12) deficiency in type 2 diabetes (T2D) patients, although the underlying mechanisms are unclear. Accumulating evidence has shown that metformin may exert beneficial effects by altering the metabolism of the gut microbiota, but whether it induces human B12 deficiency via modulation of bacterial activity remains poorly understood. Here, we show that both metformin and the other biguanide drug phenformin markedly elevate the accumulation of B12 in E. coli. By functional and genomic analysis, we demonstrate that both biguanides can significantly increase the expression of B12 transporter genes, and depletions of vital ones, such as tonB, nearly completely abolish the drugs’ effect on bacterial B12 accumulation. Via high-throughput screens in E. coli and C. elegans, we reveal that the TetR-type transcription factor RcdA is required for biguanide-mediated promotion of B12 accumulation and the expressions of B12 transporter genes in bacteria. Together, our study unveils that the antidiabetic drug metformin helps bacteria gather B12 from the environment by increasing the expressions of B12 transporter genes in an RcdA-dependent manner, which may theoretically reduce the B12 supply to T2D patients taking the drug over time.
Comparative transcriptomics reveals highly conserved regional programs between porcine and human colonic enteric nervous system
Authors: Li Tao , Morselli Marco , Su Trent , Million Mulugeta , Larauche Muriel , Pellegrini Matteo , Taché Yvette , Yuan Pu-Qing 
Published: January 2023

AbstractThe porcine gut is increasingly regarded as a useful translational model. The enteric nervous system in the colon coordinates diverse functions. However, knowledge of the molecular profiling of porcine enteric nerve system and its similarity to that of human is still lacking. We identified the distinct transcriptional programs associated with functional characteristics between inner submucosal and myenteric ganglia in porcine proximal and distal colon using bulk RNA and single-cell RNA sequencing. Comparative transcriptomics of myenteric ganglia in corresponding colonic regions of pig and human revealed highly conserved programs in porcine proximal and distal colon, which explained >96% of their transcriptomic responses to vagal nerve stimulation, suggesting that porcine proximal and distal colon could serve as predictors in translational studies. The conserved programs specific for inflammatory modulation were displayed in pigs with vagal nerve stimulation. This study provides a valuable transcriptomic resource for understanding of human colonic functions and neuromodulation using porcine model.
Murine breast cancers disorganize the liver transcriptome in a zonated manner
Authors: Vandenbon Alexis , Mizuno Rin , Konishi Riyo , Onishi Masaya , Masuda Kyoko , Kobayashi Yuka , Kawamoto Hiroshi , Suzuki Ayako , He Chenfeng , Nakamura Yuki , Kawaguchi Kosuke , Toi Masakazu , Shimizu Masahito , Tanaka Yasuhito , Suzuki Yutaka , Kawaoka Shinpei 
Published: January 2023

AbstractThe spatially organized gene expression program within the liver specifies hepatocyte functions according to their relative distances to the bloodstream (i.e., zonation), contributing to liver homeostasis. Despite the knowledge that solid cancers remotely disrupt liver homeostasis, it remains unexplored whether solid cancers affect liver zonation. Here, using spatial transcriptomics, we thoroughly investigate the abundance and zonation of hepatic genes in cancer-bearing mice. We find that breast cancers affect liver zonation in various distinct manners depending on biological pathways. Aspartate metabolism and triglyceride catabolic processes retain relatively intact zonation patterns, but the zonation of xenobiotic catabolic process genes exhibits a strong disruption. The acute phase response is induced in zonated manners. Furthermore, we demonstrate that breast cancers activate innate immune cells in particular neutrophils in distinct zonated manners, rather than in a uniform fashion within the liver. Collectively, breast cancers disorganize hepatic transcriptomes in zonated manners, thereby disrupting zonated functions of the liver.
Influence of air exposure on structural isomers of silver nanoparticles
Authors: Vernieres Jerome , Tarrat Nathalie , Lethbridge Sean , Watchorn-Rokutan Erica , Slater Thomas , Loffreda David , Palmer Richard E. 
Published: January 2023

AbstractUp to date, the influence of ambient air exposure on the energetics and stability of silver clusters has rarely been investigated and compared to clusters in vacuum. Silver clusters up to 3000 atoms in size, on an amorphous carbon film, have been exposed to ambient air and investigated by atomic-resolution imaging in the aberration-corrected Scanning Transmission Electron Microscope. Ordered structures comprise more than half the population, the rest are amorphous. Here, we show that the most common ordered isomer structures is the icosahedron. These results contrast with the published behaviour of silver clusters protected from atmospheric exposure, where the predominant ordered isomer is face-centred cubic. We propose that the formation of surface oxide or sulphide species resulting from air exposure can account for this deviation in stable isomer. This interpretation is consistent with density functional theory calculations based on silver nanoclusters, in the size range 147-201 atoms, on which methanethiol molecules are adsorbed. An understanding of the effects of ambient exposure on the atomic structure and therefore functional properties of nanoparticles is highly relevant to their real-world performance and applications.
Self-transport of swimming bacteria is impaired by porous microstructure
Authors: Dehkharghani Amin , Waisbord Nicolas , Guasto Jeffrey S. 
Published: January 2023

AbstractMotility is a fundamental survival strategy of bacteria to navigate porous environments, where they mediate essential biogeochemical processes in quiescent wetlands and sediments. However, a comprehensive understanding of the mechanisms regulating self-transport in the confined interstices of porous media is lacking, and determining the interactions between cells and surfaces of the solid matrix becomes paramount. Here, we precisely track the movement of bacteria (Magnetococcus marinus) through a series of microfluidic porous media with broadly varying geometries and show how successive scattering events from solid surfaces decorrelate cell motion. Ordered versus disordered media impact the cells’ motility over short ranges, but their large-scale transport properties are regulated by the cutoff of their persistent motility. An effective mean free path is established as the key geometrical parameter controlling cell transport, and we implement a theoretical model that universally predicts the effective cell diffusion for the diverse geometries studied here. These results aid in our understanding of the physical ecology of swimming cells, and their role in environmental and health hazards in stagnant porous media.
Multifunctionality of temperate alley-cropping agroforestry outperforms open cropland and grassland
Authors: Veldkamp Edzo , Schmidt Marcus , Markwitz Christian , Beule Lukas , Beuschel René , Biertümpfel Andrea , Bischel Xenia , Duan Xiaohong , Gerjets Rowena , Göbel Leonie , Graß Rüdiger , Guerra Victor , Heinlein Florian , Komainda Martin , Langhof Maren , Luo Jie , Potthoff Martin , van Ramshorst Justus G. V. , Rudolf Carolin , Seserman Diana-Maria , Shao Guodong , Siebicke Lukas , Svoboda Nikolai , Swieter Anita , Carminati Andrea , Freese Dirk , Graf Torsten , Greef Jörg M. , Isselstein Johannes , Jansen Martin , Karlovsky Petr , Knohl Alexander , Lamersdorf Norbert , Priesack Eckart , Wachendorf Christine , Wachendorf Michael , Corre Marife D. 
Published: January 2023

AbstractIntensively managed open croplands are highly productive but often have deleterious environmental impacts. Temperate agroforestry potentially improves ecosystem functions, although comprehensive analysis is lacking. Here, we measured primary data on 47 indicators of seven ecosystem functions in croplands and 16 indicators of four ecosystem functions in grasslands to assess how alley-cropping agroforestry performs compared to open cropland and grassland. Carbon sequestration, habitat for soil biological activity, and wind erosion resistance improved for cropland agroforestry (P ≤ 0.03) whereas only carbon sequestration improved for grassland agroforestry (P < 0.01). In cropland agroforestry, soil nutrient cycling, soil greenhouse gas abatement, and water regulation did not improve, due to customary high fertilization rates. Alley-cropping agroforestry increased multifunctionality, compared to open croplands. To ameliorate the environmental benefits of agroforestry, more efficient use of nutrients is required. Financial incentives should focus on conversion of open croplands to alley-cropping agroforestry and incorporate fertilizer management.
Synergistic effect of exfoliation and substitutional doping in graphitic carbon nitride for photocatalytic H2O2 production and H2 generation: a comparison and kinetic study
Authors: Mishra Bhagyashree Priyadarshini , Acharya Lopamudra , Parida Kulamani 
Published: January 2023

The fabricated exfoliated e-BCN demonstrated stupendous H2O2 production and H2 generation owing to sufficient active surface area and enhanced aromatic π-conjugation, faster charge migration/separation efficiency.
Numerical‐discrete‐scheme‐incorporated recurrent neural network for tasks in natural language processing
Authors: Liu Mei , Luo Wendi , Cai Zangtai , Du Xiujuan , Zhang Jiliang , Li Shuai 
Published: January 2023

AbstractA variety of neural networks have been presented to deal with issues in deep learning in the last decades. Despite the prominent success achieved by the neural network, it still lacks theoretical guidance to design an efficient neural network model, and verifying the performance of a model needs excessive resources. Previous research studies have demonstrated that many existing models can be regarded as different numerical discretizations of differential equations. This connection sheds light on designing an effective recurrent neural network (RNN) by resorting to numerical analysis. Simple RNN is regarded as a discretisation of the forward Euler scheme. Considering the limited solution accuracy of the forward Euler methods, a Taylor‐type discrete scheme is presented with lower truncation error and a Taylor‐type RNN (T‐RNN) is designed with its guidance. Extensive experiments are conducted to evaluate its performance on statistical language models and emotion analysis tasks. The noticeable gains obtained by T‐RNN present its superiority and the feasibility of designing the neural network model using numerical methods.
Performance improvement of an indirect AC/DC/AC matrix converter‐based IPMSM drive system under unbalanced three‐phase input voltages
Authors: Liu Tian‐Hua , Li Hong‐Wen 
Published: January 2023

AbstractMost matrix converters use indirect control, which includes a three‐phase virtual AC/DC converter and a virtual inverter, to control their nine AC switches. However, matrix converters do not use electrolytic capacitors to store energy. As a result, unbalanced three‐input voltages directly cause unbalanced three‐phase output voltages, which deteriorate the performance of IPMSM drive systems. To solve this problem, this paper proposes an improved method, which includes inverter stage control and AC/DC stage control, for matrix converter‐based IPMSM drive systems under unbalanced three‐phase input voltages. The inverter stage control adjusts the duty cycles of the virtual inverter to compensate for the fluctuations of the virtual DC‐bus voltage. Therefore, the harmonic currents of the IPMSM are significantly reduced, and the speed ripples of the IPMSM are reduced as well. The AC/DC stage control uses a virtual AC/DC converter to control the three‐phase input currents near sinusoidal waveforms with a unity power factor. Finally, a hybrid algorithm that combines the inverter stage control and the AC/DC stage control is demonstrated. A digital signal processor, type SH 7237, and a field programmable gate array, type 10M16SAU16917G, are used in parallel as the computational and control center.
Hybridization of particle swarm optimization algorithm with neural network for COVID‐19 using computerized tomography scan and clinical parameters
Authors: Sameer Humam Adnan , Gharghan Sadik Kamel , Mutlag Ammar Hussein 
Published: January 2023

AbstractThe 2019 coronavirus disease began in Wuhan, China, and spread worldwide. This pandemic was concerning, given its significant and worrying impact on human health. Strategies to manage the disease begin with diagnosing the infection, often using the real‐time reverse transcription polymerase chain reaction (RT‐PCR) assay. However, this process is time intensive. Therefore, alternative rapid methods to diagnose the coronavirus with high accuracy are needed. X‐ray and computerized tomography (CT) scans are reasonable solutions for rapid coronavirus diagnosis. The dataset of 500 patients was tested, including 286 uninfected patients and 214 infected with COVID‐19. Clinical parameters, including heart rate (HR), temperature (T), blood oxygen level, D‐dimer, and CT scan, including red‐green‐blue (RGB) pixel values of the left and right lungs, were collected from 500 patients and used to train an artificial neural network (ANN) to diagnose coronavirus. The ANN was hybridized with a particle swarm optimization (PSO) algorithm to improve diagnosis accuracy. The results show that the proposed PSO‐ANN method significantly improved diagnosis accuracy (98.93%), sensitivity (100%), and specificity (98.13%). The effectiveness of the proposed method was confirmed by comparing the findings with those of previous studies.
Fast frequency response technology of photovoltaic power plant based on equivalent modelling
Authors: Yin Yu 
Published: January 2023

AbstractWith the centralized access of large capacity and high proportion of new energy to the power grid, the power structure has undergone great changes, and the fast frequency response resources available to the power grid have gradually decreased. If high‐power DC blocking occurs, it will pose a serious threat to the frequency security of the power grid, and the frequency regulation pressure of the power grid and the risk of safe operation will continue to increase. To this end, a fast frequency response technology for photovoltaic power plants based on equivalent modelling is proposed. According to the principle of equivalent modelling, the equivalent model of a single unit of photovoltaic power station is established through the parameters of photovoltaic array, photovoltaic inverter, unit transformer, unit transformer and collector line. According to the fast frequency response performance requirements of photovoltaic power plants, combined with the characteristics of photovoltaic power plants, a feasible scheme for fast frequency response of photovoltaic power plants is introduced. The case study on the implementation of fast frequency response project in photovoltaic power station shows that according to the order and type of AGC command and fast frequency response command, photovoltaic power station has conducted command superposition tests under 50 ±0.2 Hz and 50 ±0.09 Hz disturbance amplitudes respectively, and the results are qualified. The integration of automatic generation control/automatic voltage control (AGC/AVC) and fast frequency response function of photovoltaic power station is realized by using relevant technologies, so that the photovoltaic power station can actively support the grid frequency and voltage.
Les enjeux éthiques du suivi à long terme des cancers pédiatriques
Authors: Camus Agathe , Henry Julie 
Published: January 2023

Dans l’article précédent, nous avons abordé les contours fragiles et fluctuants de ce qui est appréhendé comme une « vie normale » par les personnes guéries d’un cancer dans l’enfance ainsi que la manière dont celle-ci devient un objet d’interlocution complexe et singulier pour les professionnels de santé impliqués dans le suivi à long terme des cancers pédiatriques. Le présent article décrit la seconde étape de l’enquête qualitative que nous avons menée, reposant sur la mise en place d’un groupe de réflexion éthique. Elle a permis de révéler la manière dont le suivi à long terme vient questionner et transformer les pratiques de soin et de suivi dans le champ de la cancérologie pédiatrique. Il précise également l’apport spécifique de la philosophie de terrain dans ce contexte.
Maltraitance envers les enfants et Covid-19
Authors: Loiseau Mélanie , Cottenet Jonathan , Gilard-Pioc Séverine , François-Purssell Irène , Mikaeloff Yann , Quantin Catherine 
Published: January 2023

En France, au début de l’année 2020, environ 690 000 vies ont pu être épargnées grâce au confinement général de la population et aux mesures restrictives de lutte contre la Covid-19. Conséquence inattendue, ces mesures ont eu un impact sur une autre frange vulnérable de la population : celle des jeunes enfants, pour lesquels il a été démontré une augmentation des maltraitances subies à cette période. À partir de données de la littérature et de l’apport de nos travaux de recherche dans le domaine, nous proposons une documentation de cette crise des violences intra-familiales, intriquée dans la crise sanitaire de la Covid-19.
Effects of Exercise Intervention Based on Self-efficacy Theory on
Pregnant Women with Gestational Diabetes Mellitus
Authors: Tan Yingyao , Huang Fangying , Wang Yan , Lan Yutao , Cai Shu 
Published: January 2023

Abstract
Background During pregnancy, gestational diabetes mellitus (GDM)is a
common complication. Although some exercise programs have been recommended
clinically, many pregnant women have low exercise compliance, making it
difficult to effectively control blood sugar. Therefore, this study constructed
an exercise intervention plan based on self-efficacy theory and explored the
effect of the program on blood glucose and pregnancy outcomes in patients with
gestational diabetes mellitus.
Methods A randomized controlled trial was conducted. A usual exercise
program was implemented for the participants in the control group, and the
participants in the intervention group received an exercise program on the basis
of the control group and combined with the self-efficacy theory. Participants
were assessed based on exercise self-efficacy, blood glucose, weight gain,
exercise compliance, and pregnancy outcomes at week 4, week 8 and week 12.
Results One hundred three gestational diabetes mellitus patients were
recruited at baseline, 53 in the intervention group and 50 in the control group.
After the intervention, the exercise self-efficacy score and exercise compliance
of the intervention group were higher than those of the control group
(P<0.05). Fasting blood glucose, 2-h post-prandial plasma glucose,
weight gain during the intervention period, incidence of neonatal hypoglycemia,
and incidence of gestational hypertension were lower than those in the control
group (P<0.05).
Conclusion Implementing an exercise intervention based on self-efficacy
theory for gestational diabetes mellitus patients can improve exercise
self-efficacy and exercise compliance, effectively control blood glucose and
weight gain, improve pregnancy outcomes, and promote maternal and infant
safety.
Can white-light endoscopy or narrow-band imaging avoid biopsy of colorectal endoscopic mucosal resection scars? A multicenter randomized single-blind crossover trial
Authors: João Mafalda , Areia Miguel , Pinto-Pais Teresa , Gomes Luís Correia , Saraiva Sofia , Alves Susana , Elvas Luís , Brito Daniel , Saraiva Sandra , Teixeira-Pinto Armando , Claro Isabel , Dinis-Ribeiro Mário , Cadime Ana Teresa 
Published: January 2023

Abstract
Background Current guidelines suggest that routine biopsy of post-endoscopic mucosal resection (EMR) scars can be abandoned, provided that a standardized imaging protocol with virtual chromoendoscopy is used. However, few studies have examined the accuracy of advanced endoscopic imaging, such as narrow-band imaging (NBI) vs. white-light endoscopy (WLE) for prediction of histological recurrence. We aimed to assess whether NBI accuracy is superior to that of WLE and whether one or both techniques can replace biopsies.
Methods The study was a multicenter, randomized, pathologist-blind, crossover trial, with consecutive patients undergoing first colonoscopy after EMR of lesions ≥ 20 mm. Computer-generated randomization and opaque envelope concealed allocation. Patients were randomly assigned to scar examination with NBI followed by WLE (NBI + WLE), or WLE followed by NBI (WLE + NBI). Histology was the reference method, with biopsies being performed for all tissues.
Results The study included 203 scars (103 in the NBI + WLE group, 100 in the WLE + NBI group). Recurrence was confirmed histologically in 29.6 % of the scars. The diagnostic accuracy of NBI was not statistically different from that of WLE (95 % [95 %CI 92 %–98 %] vs. 94 % [95 %CI 90 %–97 %]; P = 0.48). The negative predictive values (NPVs) were 96 % (95 %CI 93 %–99 %) for NBI and 93 % (95 %CI 89 %–97 %) for WLE (P = 0.06).
Conclusions The accuracy of NBI for the diagnosis of recurrence was not superior to that of WLE. Endoscopic assessment of EMR scars with WLE and NBI achieved an NPV that would allow routine biopsy to be avoided in cases of negative optical diagnosis.