bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triamcinolone acetonide induces the autophagy of Ag85B-treated WI-38 cells via SIRT1/FOXO3 pathway
Authors: Luo Li , Zhou Lei , Luo Linzi , Feng Dan , Ding Yan , Lu Zhibin , Nie Ganjuan , Bai Liqiong , Xiao Yangbao 
Published: March 2023

Background: Tracheobronchial stenosis due to tuberculosis (TSTB) seriously threatens the health of tuberculosis patients. The inflammation and autophagy of fibroblasts affect the development of TSTB. Triamcinolone acetonide (TA) can regulate the autophagy of fibroblasts. Nevertheless, the impact of TA on TSTB and underlying mechanism has remained unclear.
Objective: To study the impact of TA on TSTB and underlying mechanism.
Material and Methods: In order to simulate the TSTB-like model in vitro, WI-38 cells were exposed to Ag85B protein. In addition, the cell counting kit (CCK)-8 assay was applied to assess the function of TA in Ag85B-treated WI-38 cells. Quantitative real-time polymerase chain reaction was applied to detect the mRNA level of sirtuin 1 (SIRT1) and forkhead box O3 (FOXO3a), and autophagy-related proteins were evaluated by Western blot analysis. Vascular endothelial growth factor (VEGF) level was investigated by immunohistochemical staining. Enzyme-linked immunosorbent serologic assay was applied to detect the secretion of inflammatory cytokines. Furthermore, hematoxylin and eosin staining was applied to observe tissue injuries.
Results: Ag85B affected WI-38 cell viability in a limited manner, while TA notably suppressed Ag85B-treated WI-38 cell viability. TA induced the apoptosis of Ag85B-treated WI-38 cells in a dose-dependent manner. In addition, Ag85B-treated WI-38 cells demonstrated the upregulation of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), interferon gamma (IFN-γ), and fibrotic proteins (transforming growth factor-beta [TGF-β] and vascular endothelial growth factor [VEGF]), which can be significantly destroyed by the TA. Meanwhile, TA reversed Ag85-induced inhibition of cell autophagy by mediation of p62, LC3, and Beclin1. Furthermore, silencing of SIRT1/FOXO3a pathway could reverse the effect of TA on the autophagy of Ag85B-treated cells.
Conclusion: TA significantly induced the autophagy of fibroblasts in Ag85B-treated cells by mediation of SIRT1/FOXO3 pathway. This study established a new theoretical basis for exploring strategies against TSTB.
A política de regularização fundiária na cidade de Belém do Pará: estudo de caso do bairro de Fátima
Authors: Nylander Pamella Isabela Alvarez , Cortese Tatiana Tucunduva Philippi 
Published: March 2023

O acesso à terra urbanizada e a garantia do direito à moradia são temas relevantes para a construção de uma cidade sustentável e entende-se que a política de regularização fundiária urbana pode contribuir para desenvolvimento da cidade. O município de Belém, capital do estado do Pará, está executando um novo programa de regularização fundiária, sendo escolhido o bairro de Fátima para o estudo de caso deste trabalho. Será apresentado o estudo de caso fruto da elaboração de pesquisa de dissertação de mestrado para o Programa de Pós-Graduação em Cidades Inteligentes e Sustentáveis com objetivo de conhecer os impactos causados na realidade dos moradores do bairro que passa por política de regularização fundiária de interesse social.
PALAVRAS-CHAVE: Regularização fundiária, cidade.
Aplicación de Lean Manufacturing en la productividad del proceso de elaboración de conservas de pescado
Authors: Ayala Siccha Noelia Llamile , Jara Aguilar Milene Astrid , Castillo Martínez William Esteward , Mantilla Rodríguez Luis Alfredo 
Published: March 2023

El presente trabajo tuvo como propósito implementar Lean Manufacturing en la planta de conservas de pescado para aumentar la productividad de la empresa Don Fernando S.A.C., se empleó un diseño pre experimental con pre prueba y post prueba, en la muestra estuvieron implicadas las áreas más críticas del proceso productivo. Para determinar los tiempos de ciclo del proceso se empleó el VSM donde se obtuvo los procesos críticos, siendo estos el área de fileteado, envasado, sellado, cocinado, exhausting y producto terminado, consiguiendo un tiempo de ciclo de 1.151 min/caja, de modo que en la productividad total inicialmente se alcanzó un 79.9 %, empleando para su solución las herramientas 5S, TPM y PHVA, lo que dio como resultado que las 5S lograra un cumplimiento de 66%, el TPM por otro lado disminuyo las horas de las fallas de los equipos a 8.5 horas y finalmente el PHVA el cual se realizó un Kardex y un Layout para la mejora del almacén en cual se redujo en 243.45 de espacio, reduciendo de esta manera los desperdicios Lean (sobre producción, sobre procesamiento, inventario, talento no utilizado, movimiento, transporte y movimiento), mejorando el tiempo de ciclo a 1.005 min/caja, concluyendo que la implementación de esta herramienta para la mejora de los procesos aumento la productividad total en un 89 %.
Influencia del uso del Lean Manufacturing en la productividad: caso empresa lavado de vehículos Carwash, Chimbote - Perú
Authors: Manrique Rivera Gilary Valeria , Mejía Vásquez Carol Geraldine , Chucuya Huallpachoque Roberto Carlos , Mariños Rosado Diego Jhovanny 
Published: March 2023

En la investigación se aplicó el Lean Manufacturing para mejorar la productividad de la empresa carwash María José, Chimbote, la metodología fue de tipo aplicada, con diseño preexperimental. La muestra estuvo conformada por 2 trabajadores de la empresa; para el desarrollo se elaboró un diagrama de operaciones de proceso, diagrama de Ishikawa, cursograma analítico, mapa de flujo de valor (VSM) y la metodología de las 5S. Los resultados de la aplicación se pudieron evidenciar en la disminución considerable con respecto al tiempo de ciclo de proceso de 53 minutos a 48 minutos; en el porcentaje de las actividades productivas de 48.72 a 58.97% y actividades no productivas de 51.28 a 41.03%, con respecto a la productividad en los meses de estudio, se obtuvo una productividad de mano de obra incremento en 0.10%, en la eficiencia aumentó en 0.08%, en costo de mano de obra en 0.05% y en productividad multifactorial en 0.04%, asimismo, se logró reducir en 3.03 litros de agua por vehículo en el proceso. Se concluyo que las herramientas de Lean Manufacturing mejora la productividad.
Routine fetal echocardiography for detection of congenital heart disease-mandatory or an optional tool?
Authors: Gupta Tanvi , Ganjoo Sandesh , Kaul Varun , Makhija Rashmi Khilnani , Mishra Smita , Sareen Sugandh 
Published: March 2023

Background: Aim of the study was to assess the role of fetal echocardiography in identification of antenatal cardiac defects in a tertiary care centre in North India.
Methods: Prospective study done in a tertiary care centre in North India on female patients presenting to a tertiary care centre with pregnancy over a period of two years. All routine investigations were done and specific examination in the form of a screening fetal echocardiography was done in the selected two groups of patients, high and low risk.
Results: A sample size of 250 patients with intrauterine pregnancy of 18-28 weeks of gestation was analyzed. A detailed history, examination and fetal echocardiography was performed in all the patients. In group I-105 patients with elevated risk factors (for congenital heart disease) (CHD) were included whereas in group II-145 patients with low risk factors were taken. The various demographic parameters among the two groups were almost similar. The outcome was also similar in two groups with nil neonatal mortality. Except for the NICU admission between the two groups, rest all the parameters whether maternal or neonatal were not statistically significant.
Conclusions: In the present study, we tried to find out role of fetal echocardiography for detection of CHD in high and low risk cases. The results were almost similar in both high and low risk group. Indications of referral for fetal echocardiography cannot be listed as it was found that almost similar percentage of heart defects are seen in both groups I and II.
Role of serum vitamin D levels in patients with chronic tonsillitis in paediatric age group
Authors: Pallavi Saroch  , Aditya Saraf  , Vikas Mahajan  , Gopika Kalsotra  , Parmod Kalsotra  
Published: March 2023

Background: Vitamin D has got an important role in the defence system of our body. Objective were to assess the vitamin D levels in chronic tonsillitis and to find the association between the vitamin D deficiency and chronic tonsillitis in paediatric age group.
Methods: A total of 325 patients aged between 5 and 15 years were enrolled in this study who were diagnosed with recurrent tonsillitis between January 2021 and December 2022. The patients were followed-up for one year and the total episodes of acute tonsillitis were recorded. Patients were divided into three groups: Those who had <5 episodes per year (Group 1), those with >5 episodes per year (Group 2) in the last two years, those who come to OPD with otological complaint, with no tonsillar involvement as a control group (Group 3). The total number of recurrent tonsillitis episodes within one year, demographic characteristics and the mean serum 25 (OH) D levels of the groups were compared.
Results: The tonsil size according to the Brodsky Scale and the mean 25 (OH) D levels were compared and we found, lower vitamin D levels were significantly associated with larger tonsil sizes (p=0.023).
Conclusions: There is a statistically significant association between vitamin D levels and recurrent episodes of tonsillitis. As the grade of tonsillar enlargement increased, the level of vitamin D were reduced significantly, thus correlating vitamin D levels not only with recurrence, but also grade of tonsillar enlargement.
Comparison of the Effect of two E-learning Methods, Problem Solving and Examination Question on Awareness; Attitude and Performance of Islamic Azad University –Maybod branch Nursing and Midwifery Students Regarding Hospital Infection Control in 2022
Authors: Esmaili Vardanjani F , Shojaaddini Ardakani T , Bitaraf M , Shadmani Shademani Dastjerdi SH , Marvastinia Gh 
Published: March 2023

Introduction: Hospital infections are one of the most common health problems which can be controled by education. The purpose of this study was to compare the effect of two e-learning methods (problem solving and examination of question) on awareness; Attitude and performance of Islamic Azad University–Maybod branch nursing and midwifery students regarding hospital infection control in 2022.
Methods: The current study was a semi experimental in which 36 Islamic Azad University–Maybod branch nursing and midwifery students were randomly Probability Proportional to Size assigned to intervention(problem solving, examination question) and control groups (N=12) based on the entry and exit criteria using probability proportional to size method. Education based on hospital infections booklet was assigned. Before and after the intervention, students’ knowledge, attitude and performance scores were evaluated using a standared questionnaire (alpha=0/82). The distribution of quantitative variables was done using the Kolmograph Smirnov test and parametric statistical tests (t_test/pair t_test/one way anova t test) considering the significance level of 0.05.
Results: Comparing the scores of awareness (p=0.993), attitude (p=0.997) and performance (p=0.998) in the intervention groups; there is no significant difference and it means the same effect of two educational methods. Teaching two methods of problem solving – question and answer has no effect on improving students’ short-term attitude (p=0.172) and improving long-term performance scores (p=0.075). The effect of education in the two ways mentioned on improving awareness; Long-term attitude and short-term performance were significant (p<0.05).
Conclusion: e-learning in two ways of problem solving-examination question in increasing the average scores of knowledge; Attitude and performance have been equally effective.
ANALISIS FAKTOR YANG MEMPENGARUHI MOTIVASI KADER POSYANDU BALITA DI KELURAHAN PURWOKERTO KIDUL
Authors: Setyo Upoyo Arif , Sumarwati Made 
Published: March 2023

A few people want to be a Posyandu cadre. Be a cadre, time, energy, and money should be charitable. In Kecamatan Purwokerto Kidul, there are 10 Posyandu, which take care of 350 children under 5 years old. Each Posyandu has at least 4 health cadres which actively give attention to those children. This shows a very big community’s contribution. This study wants to explore what factors that contributes to cadre’s motivation. Descriptive analytic design was chosen. Thirty two cadres were collected through purposive sampling. Data were analyzed through chi square and logistic regression. Data analysis found that internal support (sig. 0.000), self esteem (sig. 0.002), external support (sig. 0.258), wage (sig. 0.440) and others appreciation (sig. 0.227). This can be concluded that internal motivation and self esteem was significantly motivated cadre to actively take care of the children. External support, wage and others appreciation played a little contribution in cadre’s motivation. Key words : level of motivation, Posyandu cadre
*) lecturer Nursing Program FKIK Unsoed
STUDI PREVALENSI GAKY DI KABUPATEN BANYUMAS TAHUN 2007
Authors: Kusumawati Erna , Sri Rejeki Dwi Sarwani , Munir Misbakhul 
Published: March 2023

Iodium Deficiensy Disorder (IDD) is a group of symptom which arising from body lacking of element iodium continually within sufficiently long, one of indicator used to measure the level of problem in community that is by measure of prevalensi endemic thyroid with Total Prevalency Goiter (TGR)
The objectives of this study was to prevalensi IDD at women in reproductive age (WUS) in Banyumas regency year 2017.
The type of this research was descriptive survey with cross sectional study. Sampel in this this research is WUS (15-49 year) amounting to 500 people coming from 5 district in Banyumas Regency. Data collecting conducted by observation with Urinary Excretion Iodine (UEI), inspection of degree of GAKY with palpalasi method. This survey is executed in August September 2017.
Research result with palpalasi found the amount of Total Goiter Rate at WUS in Banyumas Regency Year in 2017 is 11,4% endemic category with detail degree of IA and IB (3,4%), II (4,0%). At inspection of UEI show has varying with value of lowers 3, highest value 296, average value 192,82 with standard of deviasi 64,40. At inspection of UEI known was 10,1% WUS of include in deficiencies category of iodium with heavy deficiencies (1,2%), moderate (2,8%) and lowers (6,2%). Require to continue to be improved by Communication Information and Education (KIE) so that knowledge of community concerning GAKY mount, so that effect at decrease of prevalensi GAKY.
PEMETAAN STATUS EKONOMI DENGAN MALNUTRISI PADA BALITA BERUSIA 0-59 BULAN
Authors: Nurlianna Fariza 
Published: March 2023

Berdasarkan Profil Kesehatan Kabupaten Sleman tahun 2018, sebaran prevalensi malnutrisi di wilayah kerja Puskesmas Kalasan semuanya melebihi renstra Kabupaten Sleman. Prevalensi balita gizi buruk tertinggi, prevalensi balita stunting berada pada urutan kedua tertinggi, dan prevalensi balita wasting pada urutan keempat tertinggi. Gizi buruk, kurus, dan stunting merupakan bentuk manifestasi dari adanya gangguan pada proses pertumbuhan. Tujuan penelitian adalah untuk meneliti heterogenitas ekonomi dan korelasinya dengan malnutrisi secara spasial serta memetakan wilayah-wilayah terkait malnutrisi. Penelitian menggunakan desain cross sectional dengan penentuan sample purposive clauster sampling, sebanyak 615 balita. Subyek dari penelitian adalah semua balita berusia 0-59 bulan di Desa Selomartani. Variabel bebas yaitu underweight, stunting dan wasting. Sedangkan variable terikat yaitu status ekonomi dengan kategori miskin dan tidak miskin. Analisis data menggunakan korelasi Spearman dilanjut dengan pemetaan menggunakan aplikasi ArcGIS. Prevalensi balita yang menderita underweight sebesar 13,7%, stunting sebesar 8,1% dan wasting sebesar 3,1%. Status ekonomi keluarga balita yang termasuk dalam keluarga miskin sebesar 7%. Hasil penelitian menunjukkan tidak ada hubungan status ekonomi dengan underweight (r=0,039), tidak ada hubungan status ekonomi dengan stunting (r=0,012) dan tidak ada hubungan status ekonomi dengan wasting (r=0,025). Malnutrisi ada di semua strata status ekonomi baik itu pada keluarga miskin maupun pada keluarga tidak miskin.
MAKING CHLORINE DIFFUSER IN REDUCING COLIFORM NUMBERS IN THE WELLS
Authors: Kuswanto Sanredja , Yuniarno Saudin , Hastawati Ima 
Published: March 2023

Abstrak
Lokasi penelitian berada di RW 6 Kelurahan Grendeng yang merupakan kawasan yang cukup kumuh, dengan jumlah RT sebanyak 4, yang termasuk kategori Kawasan Kumuh Program Kotaku Tahun 2016/2017. Masalah yang terdapat di kelurahan Grendeng antara lain kepadatan penduduk, jarak rumah yang sangat rapat, buruknya sanitasi dan penyediaan air bersih, jarak jamban dengan sumur gali sehingga berpengaruh terhadap kualitas air sumur gali tersebut terutama kualitas bakteriologisnya. Penanggulangan terhadap masalah tersebut dengan melakukan desinfeksi pada sumur gali dengan alat Chlorine Diffuser. Analisis yang dilakukan terhadap data hasil percobaan dalam penelitian yaitu uji univariat untuk mengetahui frekuensi kualitas lingkungan sekitar sumur gali dan analisis uji lanjut menggunkan uji Paired T Test untuk mengetahui keefektifan penggunaan alat chlorine diffuser. Berdasarkan hasil analisis uji normalitas didapatkan nilai sebesar α = 0,457 , nilai normalitas ini lebih besar dibandingkan dengan nilai α 0,05. Maka uji ini dilanjutkan dengan menggunakan uji paired T Test. Dari uji paired T Test didapatkan nilai probabilitas sebesar α = 0,000,. Maka dapat disimpulkan bahawa terdapat pengaruh penurunan angka bakteri coliform dengan menggunakan alat Chlorine Diffuser.
Authors: Aisyah Rohman Siska Nur , Sri Rejeki Dwi Sarwani , Nurlaela Sri 
Published: March 2023

Latar Belakang: COVID-19 sangat menular dan patogen. Desa Parangtritis merupakan desa wisata dengan mobilitas tinggi dan memiliki kasus fluktuatif. Perilaku pencegahan harus dilakukan masyarakat untuk mengurangi kasus yang ada, karena saat ini belum ditemukan obat spesifik untuk mengobati. Penelitian dilakukan dengan tujuan untuk mengetahui faktor-faktor yang berpengaruh terhadap perilaku pencegahan COVID-19 masyarakat Desa Parangtritis. Metode: Penelitian analitik, pendekatan cross sectional. Populasi penduduk Desa Parangtritis 5729 jiwa. 396 sampel dengan accidental sampling. Variabel yang diteliti adalah jenis kelamin, umur, pendidikan, paparan sumber informasi, pengetahuan dan sikap. Pengumpulan data menggunakan kuesioner melalui google form. Data dianalisis ke dalam univariat, bivariat, dan multivariat. Hasil Penelitian: Sebagian besar berjenis kelamin perempuan (62,1%). Umur dominan pada rentang 15-29 tahun (88,1%). Tingkat pendidikan menengah (47,7%). Sumber informasi pencegahan COVID-19 berasal dari sosial media (internet) (67,2%), dengan kategori baik (71%). Pengetahuan baik (94,4%). Sikap baik (55,6%). Perilaku baik (72,2%). Faktor yang paling mempengaruhi perilaku pencegahan COVID-19 adalah paparan sumber informasi (p-value= 0,000; POR= 11,622; CI= 6,755-19,994) dan sikap (p-value= 0,000; POR= 2,725; CI= 1,596-4,652). Kesimpulan: Terdapat hubungan jenis kelamin, umur, pendidikan, paparan sumber informasi, pengetahuan dan sikap terhadap perilaku pencegahan COVID-19. Paparan sumber informasi dan sikap merupakan faktor yang paling berpengaruh.

Kata Kunci: COVID-19; Masyarakat; Perilaku pencegahan.
Analisis Strategi Pengolahan Limbah Medis saat Pandemi COVID-19 di Indonesia
Authors: Awali Gitri Syiamil , Rahma Sinta Ainun 
Published: March 2023

Indonesia melaporkan peningkatan jumlah kasus COVID-19 setiap harinya. Per 20 Desember 2020, kasus terkonfirmasi mencapai 664.930 kasus dengan total kematian sebanyak 19.880 jiwa. Seiring dengan bertambahnya kasus terkonfirmasi, maka akan mengakibatkan peningkatan limbah medis seperti masker medis, jas hazmat, sarung tangan, dan limbah infeksius lainnya. Limbah medis infeksius yang dihasilkan akan berdampak negatif, yaitu dapat mencemari lingkungan serta memperluas transmisi COVID-19. Oleh karena itu, diperlukan strategi pengolahan limbah medis yang tepat sesuai standar supaya tidak memperluas transmisi COVID-19, terutama di Indonesia. Literature review ini dilakukan untuk mengetahui proses pengolahan limbah medis yang dilakukan selama pandemi COVID-19 di Indonesia serta mengetahui standar pengolahan limbah medis, baik secara nasional maupun internasional. Strategi pengolahan limbah medis selama pandemi COVID-19 di Indonesia belum sepenuhnya memenuhi standar karena masih terbatasnya fasilitas pengolahan limbah medis.
Kata Kunci : COVID-19, pengolahan limbah, peraturan, limbah medis.
THE UTILIZATION OF GEO VISUALIZA THE UTILIZATION OF GEO VISUALIZATION TO DETERMINE THE FINAL WASTE DISPOSAL LOCATIONS IN BANYUMAS REGENCY
Authors: Nurhayati Siti , Kuswanto Kuswanto , Syafei Mohamad 
Published: March 2023

ABSTRACT

The increasing population in Banyumas Regency has consequently impacted on the increasing amount of waste to manage. The old final waste disposal places are no longer capable to hold the amount of waste produced by the people of Banyumas Regency. Thus, Banyumas Regency has recently been in the emergency state dealing with its waste management. Banyumas Regency requires new final waste disposal locations since the old ones are no longer feasible. Thus, it is required to find new final waste disposal locations. This research employed a descriptive method with a spatial approach. The geographic information system (GIS) was performed to determine the final waste disposal locations by using the weighing and scoring method followed with the overlay maps. Those maps included the administrative map, river map, land-use map, waste-risk area map, flood-prone-area, landslide-prone area, earthquake-prone-area, fault map, slope map, rainfall map, and population density map. The results of this research show that the alternative final waste disposal locations in Banyumas Regency are best located in Kalibagor district covering the areas of Srowot, Kalisorga Wetan, Petir, and Pajerukan Village; while in Purwojati district covering the area of Purwojati and Karangtalun Kidul Village.

Keywords: spatial analysis, Final Waste Disposal, waste
EFEKTIVITAS METODE KELAS MEMASAK BAGI IBU BALITA UNTUK MENCEGAH STUNTING DI DESA JIPANG KECAMATAN KARANGLEWAS
Authors: Nur Amalia Aina Shofi Salsabila , Sri Rejek Dwi Sarwani , Sari Ellin Novitha , Rachmani Nadia Nurazizah , Rahmatika Nanda Tri , Sudrajat Nida Fauziah 
Published: March 2023

Jipang is one of the villages that belong to the working area of Karanglewas Community Health Center (Puskesmas) with a great number of stunting cases. The prevalence of stunting cases in Jipang village was 35 cases (16.13%) out of a total 217 toddlers. One of the main factors contributing to the high cases of stunting in Jipang village is the lack of knowledge and skills among mothers in taking care of their children. Many mothers have limited knowledge of parenting, particularly in terms of providing their children with proper nutrition. Besides, due to limited educational media, mothers are less informed about good parenting. In order to prevent the rising number of stunting cases, there is a need to improve mothers’ knowledge and skills in providing their children with good parenting. The aim of this activity was to improve mothers’ knowledge and skills in providing their children with good parenting. This activity consisted of a number of stages including 1) Writing a recipe book about food preventing stunting, 2) Creating leaflet and educational videos, 3) Educating mothers about stunting and proper nutrition, 4) Conducting a cooking class, and 5) Supervising a group of mothers. The result of this activity indicated that there was an improvement in terms of mothers’ knowledge and skills after the activity. Specifically, the recipe book was very useful for mothers in providing proper nutrition for their children.
Key words: Stunting, Proper Nutrition, Cooking Class