bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel fractional order Grey prediction modeland its application to Chinese carbon emissions
Authors: Li Hui , Wu Zixuan , Qian Shuqu , Duan Huiming 
Published: April 2023

Abstract
Carbon emissions have attracted widespread attention and become one of the most important research topics in the international arena. An objective and accurate prediction of carbon emissions can provide a theoretical basis for the Chinese government to set carbon reduction targets and policies, and also help China to explore a suitable carbon reduction pathway. Considering that the main source of carbon emissions is energy combustion, and the energy mix is constantly changing, new information is better able to characterize future trends. In this paper, a novel fractional-order grey multivariate forecasting model is established to analyze and forecast China's carbon emissions, reflecting the principle of new information priority. The model adds fractional order cumulative sequences to the traditional integer order cumulative sequences, uses the Gamma function to represent the fractional order sequences and the time response equation, and uses the particle swarm algorithm to find the optimal order of the cumulative. Finally, the modeling steps of the model are given. Then the new model is analyzed for its effectiveness from three different perspectives using 21 years of Chinese carbon emission data. The results of the three Cases show that the newly established particle swarm optimization fractional order model outperforms the original grey prediction model and the other three classical grey prediction models. It has stable characteristics for both simulation and prediction, and also shows high accuracy, and all three cases fully illustrate the effectiveness of the new model. Finally, this model is applied to forecast China's carbon emissions from 2022–2026, analyze the forecast results and make relevant recommendations.
Tomatidine improves liver fibrosis by promoting autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 pathway
Authors: hu xue , Shen Haotian , Tang Bin , Deng Fengmei 
Published: April 2023

Abstract
Liver fibrosis is caused by various liver diseases and eventually develops into liver cancer. Tomatidine (TD), an aglycone of α-tomatidine, is a major glycoalkaloid found in immature tomato fruits, leaves, and stems. In this study, we investigated that tomatidine may promote autophagy in hepatic stellate cells through the ERK/MAPK-mTOR-ULK1 signaling pathway to improve liver fibrosis and combined experimental validation and molecular docking to reveal the underlying mechanism. First, we found that tomatidine could inhibit the proliferation of hepatic stellate cells and the expression of fibrosis-related proteins α-smooth muscle actin (α-SMA) and collagen type I 1 gene (COL1A1) in LX2 cells. Tomatidine was found to promote the expression of autophagy-related proteins. Next, we performed a network pharmacology screen and found that among the targets of tomatidine and the common targets of tomatidine and liver fibrosis, no target related to autophagy was found in the current database. However, pharmacological studies of tomatidine have confirmed the existence of pro-autophagy pharmacological effects. Therefore, we used molecular docking to verify that tomatidine had good binding and affinity with autophagy-related targets. Further network pharmacological analysis showed that the MAPK signaling pathway may be involved in the biological process of tomatidine against hepatic stellate cells. We further verified the ERK/MAPK-mTOR-ULK1 pathway and found that tomatidine could promote autophagy in LX-2 cells by inhibiting the expression of P-ERK and P-mTOR and activating the expression of P-ULK1. Finally, molecular docking was performed to reveal the binding of tomatidine to the active sites of ERK, MAPK, mTOR, and ULK1.
The relationship between fear, loneliness, and depression among university students: A structural equation model
Authors: shindi Yousef Abdelqader Abu , Al-Bahrani Muna Abdullah , Alkharusi Hussain Ali 
Published: April 2023

Abstract
The aim of this study was to test the causal relationship among fear of Covid-19, loneliness, and depression from Covid-19. The study sample consisted of 605 undergraduate students recruited from a public university. They completed three scales: fear of Covid-19, depression from Covid-19, and loneliness. The results revealed a good fit index for the proposed path model. The fear of Covid-19 predicted two types of loneliness emotional and social negatively. A positive association between depression and emotional as well as social loneliness was found. A total of 43% of the variance in depression was explained by loneliness. Depression was potentially a mediating factor between a fear of pandemic and the feeling of loneliness. A counseling intervention can be designed based on these results.
Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits the JAK/STAT1 Pathway and Acetylation of HMGB1
Authors: Li Jie , Gao Lei , Li Yijie , feng dianxu , Chen Yafeng 
Published: April 2023

Abstract

Objective:
To investigate the effect of honokiol (HON) and the role of HMGB1 on the pathogenesis of severe acute pancreatitis (SAP) in a mouse model.
Methods :
Thirty mice were randomly divided into 5 groups: control (CON), SAP, SAP and normal saline (SAP+NS), SAP and ethyl pyruvate (SAP+EP), or SAP+HON. Samples of the pancreas, intestine, and blood were collected 12 h after model induction for examination of pathologic changes, alterations of immune function, and abnormalities of HMGB1-related pathways using microscopy, ELISA, and western blotting.
Results :
Mice with SAP had inflammatory injury of the pancreas, bleeding of intestinal tissues, and cells with disrupted histology, but mice in the SAP+HON group had significantly fewer pathological changes. Mice with SAP also had significant increases in the serum levels of amylase (AMY), lipase, HMGB1, tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), diamine oxidase (DAO), endotoxin 1 (ET-1), and procalcitonin (PCT), but mice in the SAP+HON group did not have these abnormalities. Studies of Caco-2 cells indicated that lipopolysaccharide (LPS) increased the levels of occludin and claudin-1, increased tight junction-permeability, and decreased the level of junctional adhesion molecule C (JAM-C), but HON treatment blocked these effects. Studies of macrophages indicated that LPS led to low nuclear levels of HMGB1, but HON treatment increased the nuclear level of HMGB1. HON treatment also inhibited the expression of JAK1, JAK2, and STAT1 and increased the acetylation of HMGB1.
Conclusion :
HON prevents intestinal barrier dysfunction in SAP by inhibiting HMGB1 acetylation and the JAK/STAT1 pathway.
Selective Knowledge Sharing for Privacy-Preserving Federated Distillation without A Good Teacher
Authors: Zhang Jun , Shao Jiawei , Wu Fangzhao 
Published: April 2023

Abstract
While federated learning is promising for privacy-preserving collaborative learning without revealing local data, it remains vulnerable to white-box attacks and struggles to adapt to heterogeneous clients. Federated distillation (FD), built upon knowledge distillation--an effective technique for transferring knowledge from a teacher model to student models--emerges as an alternative paradigm, which provides enhanced privacy guarantees and addresses model heterogeneity. Nevertheless, challenges arise due to variations in local data distributions and the absence of a well-trained teacher model, which leads to misleading and ambiguous knowledge sharing that significantly degrades model performance. To address these issues, this paper proposes a selective knowledge sharing mechanism for FD, termed Selective-FD. It includes client-side selectors and a server-side selector to accurately and precisely identify knowledge from local and ensemble predictions, respectively. Empirical studies, backed by theoretical insights, demonstrate that our approach enhances the generalization capabilities of the FD framework and consistently outperforms baseline methods. This study presents a promising direction for effective knowledge transfer in privacy-preserving collaborative learning.
An unilateral rapidly growing amyloid goiter associated with osteopetrosis: a Case Report and Literature Review
Authors: Jeladharan Reshma , Singh Abhijeet , Jat Bhinyaram , Phulware Ravi Hari 
Published: April 2023

Abstract
Introduction: Amyloid goiter of the thyroid is a rare disorder characterized by the deposition of amyloid proteins within the thyroid gland, leading to its enlargement and functional impairment. The exact cause of amyloid goiter remains unknown, but it is associated with multiple myeloma, systemic amyloidosis, and familial Mediterranean fever. Diagnosis is made through imaging studies and histological examination of thyroid tissue. Treatment options include observation, thyroid hormone replacement therapy, and surgical resection, depending on the extent of thyroid enlargement and functional impairment. Prognosis is generally favorable, but it depends on the underlying cause of amyloid deposition and the extent of thyroid involvement.
Case Presentation: We report a case of a 37-year-old previously healthy male who presented with a history of progressively enlarging painless neck swelling for 2-3 months. The patient was euthyroid and denied any associated symptoms. The patient subsequently underwent an uneventful hemithyroidectomy along with an unremarkable postoperative period. Histopathology examination and special stains revealed the diagnosis of amyloid goiter.
Conclusions: A strong index of suspicion is necessary in patients with an enlarged thyroid gland and a concurrent history of chronic inflammatory processes or plasma cell dyscrasia because amyloid goitre is a rare condition. The present case is unique and unusual since there is no record in the literature of an amyloid goitre being associated with osteopetrosis in a patient. To get a conclusive diagnosis and to get rid of symptoms, a thyroidectomy is required. For the diagnosis of this uncommon entity, a histopathological study is crucial. Every effort should be taken to determine the full scope of the illness, and plasma cell dyscrasia should be ruled out in people who were previously healthy.
Co-infection of Covid-19 and Malaria among staff and students of Federal University of Technology Owerri, Imo State.
Authors: Ogwudire Chukwunonyerem Chika , Madubuike Mercy Ngozi , Etoruom Christiana Ekele , Anyadoh-Nwadike Sylva Onyinyechi , Okoro Chinyere Ihuarulam 
Published: April 2023

Abstract
Background: COVID-19 and malaria syndemic poses colossal challenge in prompt diagnosis and effective management of both infections especially in tropical regions. Therefore, this survey was conducted in order to ascertain the seroprevalence of SARS-COV-2 antibodies and malaria parasite in a university located in the south-eastern part of Nigeria, shortly after the waves of COVID-19 pandemic in 2020.
Method: A total of 600 participants (400 students and 200 staff) who had provided informed consent, were randomly selected from the School of Biological Sciences, Federal University of Technology Owerri. Questionnaires were administered to collect data on respondents’ demographics and clinical history. Then, blood samples were aseptically collected by needle prick and tested for COVID-19 and malaria using the SARS-COV-2 IgM/IgG antibody test kit and the malaria test kit (Malaria Pf (HRP2) respectively.
Results: Malaria and COVID-19 co-infection rates observed among the staff and students in this survey were 5% and 1.8% respectively. Out of the 200 staff tested in this study, 45(22.5%) were IgG positive, 0(0%) were positive for IgM while 10(5%) tested positive to malaria parasite. Although, all IgG positives were junior staff. Then, amongst the 400 students tested, 37(9.25%) tested positive for IgG while none (0%) were IgM positive but, 62(15.5%) were positive for Plasmodium falciparum infection. The interrelated symptoms of malaria and COVID-19 mostly observed in our respondents were fever, headache and fatigue.
Conclusion: Results from this study further explained that the level of co-infection prevalence varies directly with the level of malaria prevalence and vice versa.
Nonlinear Enhanced Coupled Feedback Control for Bridge Crane with Uncertain Disturbances: Theoretical and Experimental Investigations
Authors: WANG TIANLEI , LIN CHENGMIN , LI RENXING , QIU JIONGZHI , HE YUEBANG , ZHOU ZHIHENG , QIU GUANGFAN 
Published: April 2023

Abstract
Anti-swing control of bridge cranes has been widely studied to improve the efficiency of industrial transportation. However, in practice, the performance of bridge crane control methods is reduced by external disturbances and internal uncertainties. Therefore, an enhanced coupled nonlinear control strategy based on feedforward compensation has been proposed in this study. Appropriate composite signals were introduced to enhance the coupling between the system states and improve the transient performance of the controller. The design of the composite signal takes into account the characteristics of crane model. The unknown disturbance was then treated as a state variable, and the crane dynamic model was transformed accordingly. Finally, the state of the model was estimated by the extended state observer, and the disturbance estimate was compensated to improve the robustness of the control system. The stability of the controller was verified through a rigorous mathematical analysis. The simulation and experimental results verified the effectiveness of the proposed method.
Forest regeneration following land abandonment is driven by historic land use affecting plant diversity and soil carbon stocks (mountainous tropical Asia)
Authors: de Rouw Anneke , Bottinelli Nicolas , Huon Sylvain , Maeght Jean-Luc , Massalis Guillaume , Podwojewski Pascal , Soulileuth Bounsamay , Van Thiet Nguyen , Welzen Peter van 
Published: April 2023

Abstract
Context Farmland on steep slopes is increasingly abandoned because it is unsuitable for most forms of modern agriculture. Succession back to forest is often slow or inexistent due to over-exploitation. Observations and measurements in Dong Cao catchment 47.9 ha Vietnam, started under farming and continued after abandonment: 20 years of uninterrupted monitoring of soil, water, land use and vegetation were integrated in this study.Objective Our aim is to identify the specific combination of soil features and agricultural practices that are responsible for fast, slow or blocked succession. We differentiate between the recovery of forest structure, relatively easy, and recovery of the original species composition, more difficult.Methods Multivariate analysis of vegetation data produced plant communities in a gradient of complexity. Using classic statistics, we sought relationships between environmental variables, land use and vegetation.Results Forest recovery failed the first 10 years, then part of the catchment developed forest. Land use explained best the distribution of plant communities over the catchment, slope and soil features were less related. Cassava cropping seriously slowed down the succession to closed forest. During abandonment soil carbon stocks (0–15 cm depth) increased with about 3% per year.Conclusion Starting from weedy thickets (2002) we distinguished two successional pathways: a positive pathway towards increased resemblance with the original Lowland forest via broken forest to closed deciduous to closed evergreen forest; a negative pathway away from the original forest species composition to degraded shrub land and low grass. Livestock was related to the negative pathway.
On bifurcations, resonances and chaos control in nonlinear Leslie matrix models
Authors: Wikan Arild , Kristensen Ørjan 
Published: April 2023

Abstract
Leslie matrix models with nonzero nonlinear fecundity elements are under consideration. In one direction we prove by use of the general Deriso-Schnute recruitment function the supercritical nature of bifurcations in 2- and 3-age class models as well as a thorough analysis of 1:2 and 1:3 resonance phenomena. Results regarding stabilizing and destabilizing effects, the impact of coexisting attractors, as well as dynamical outcomes found in general n-age class models are also provided. In another direction we study, by use of a hybrid chaos control method, to what extent it is possible to advance or delay bifurcation points and thereby change the dynamics. Among our findings here is that it is indeed possible to reduce the size of parameter space where chaotic oscillations occur. However, we have not succeeded in changing the dynamics from being quasiperiodic to periodic (i.e. from a region where the dynamics is determined by a Neimark-Sacker bifurcation to a region where the dynamics is determined by a flip bifurcation) or vice versa.
Mathematics Subject Classification (2020) MSC code37 · MSC code39
A novel nomogram for predicting overall survival in peripheral T cell lymphoma patients
Authors: Wang Yi-Ting , Geng Hai-Li , Li Xiao-Fan , Chen Ping , Xu Shu-Juan , Zhang Shu-Xia , Weng Ping , Guo Jiang-Rui , Huang Mei-Juan , Wu Yong , Chen Yuan-Zhong 
Published: April 2023

Abstract
Background The prognosis of peripheral T cell lymphomas (PTCLs) varies greatly. This study aimed at generating a prognostic nomogram based on differentially expressed genes (DEGs).Methods Firstly, we collected RNA transcripts from Gene Expression Omnibus and identified DEGs. Secondly we used univariate Cox regression, Least absolute shrinkage and selection operator (LASSO) to screen the independent risk factors to construct nomogram in the training cohort. Thirdly, we evaluate its prediction accuracy via decision curves analysis (DCA), receiver operating characteristic (ROC) and calibration rate to confirm its performance on survival in training and validation cohort. Then we carried out subgroup analysis in training and validation to eliminate the effects of age, gender, and pathological subtype. Lastly, to verify feasibility of nomogram in practice, we applied immunohistochemistry to clinical samples and analyzed the relationship between IHC scores and prognosis.Results The 702 DEGs between 40 PTCLs and 20 non-tumor patients were identified. Then ANGPTL2, CPSF4, CLIC4 and OTUD6B were screened out as independent risk factors via univariate Cox regression and LASSO. The DCA, ROC, Harrell’s concordance index (c-index) and calibration rate showed nomogram predicting more accurately than any single specific transcript. The results showed PTCLs with higher nomogram-score had a longer survival, regardless of age, gender and pathological subtype. Finally, the high expression level of ANGPTL2, CPSF4 and OTUD6B related to poor prognosis. Higher expression of CLIC4 related to longer survival.Conclusion This nomogram showed the favorable clinical applicability, regardless of age, gender and pathological subtype.
How do patients and healthcare professionals experience foot examinations in diabetes care? – a randomised controlled study of digital foot examinations versus traditional foot examinations
Authors: Tang Ulla Hellstrand , Tranberg Roy , Sundberg Leif , Scandurra Isabella 
Published: April 2023

Abstract
Background: Digital solutions in healthcare can facilitate and improve care. However, the experiences and usefulness of using either digital foot examinations or traditional foot examinations need to be evaluated.
The aims of the study were to evaluate:
1) the differences in patient experiences, having their foot examined supported by the Clinical Decision Support System (CDSS) as compared with having their foot examined in traditional practice,
2) how healthcare professionals (HCP), by using the CDSS, experienced the routine compared with performing the foot examination as in traditional practice.
Methods
Of a total of 141 patients, 100 patients with diabetes were single-blind digitally randomised to one of two parallel arms: having their foot examined by an HCP using a CDSS (n=47) or having their foot examined as in traditional practice (n=53) at the Department of Prosthetics and Orthotics at Sahlgrenska University Hospital, Gothenburg, Sweden. Patients filled in a modified version of the National Patient Survey (NPS) and the Orthotics and Prosthetics Users’ Survey (OPUS) at study end. Two HCPs, working at a Department of Prosthetics and Orthotics, answered surveys regarding the interaction between the patient and the CPO.
Results: Patients, aged 65±14 years, perceived a high level of satisfaction with the service at the department, regardless of the method used. No significant differences between groups were found when evaluated by 27 questions in the NPS or the OPUS, with scores of 67.17±12.18 vs. 66.35±16.52 (p=0.78) for the intervention and control group respectively. One hundred per cent of the patients were risk classified in the intervention group compared with 2% in the control group.
Conclusions: Patients perceived a high level of satisfaction with the services at the DPO, regardless of the method used for the foot examination. All the patients were risk classified in the intervention group. The HCPs found that, by using the CDSS, the foot examination was structured and followed clinical guidelines. Furthermore, the documentation in the electronic health record was thorough, even though further improvements, such as integration with co-existing health record systems, were requested.
Trial registration: Clinical Trials NCT03088566, Registered 23 March 2017, https://clinicaltrials.gov/ct2/show/NCT03088566?cond=d-foot&draw=2&rank=3
Assessing non-native invasive Orthoptera in Europe
Authors: Kulessa Anna K. , Kouba Antonín , Renault David , Soto Ismael , Haubrock Phillip J. 
Published: April 2023

AbstractOrthoptera encompasses 29,000 species. Due to their ability to migrate long-distances through hitchhiking or active dispersal but also due to their wide dietary spectrum, several orthoptera species can pose a phytosanitary threat. Despite information being scarce and contrasting among sources, we compiled literature on non-native Orthoptera species in Europe for this scoping review. We identified 41 relevant species, 35 are non-native (non-native to Europe n = 8, partly native to Europe n = 21, native range unknown/no information available n = 6), two arguably invasive species to Europe due to proven impacts, two are questionable and another two cryptogenic. Of these, 23 species are considered established. The two invasive orthopterans were the Moroccan LocustDociostaurus maroccanusand the Desert LocustSchistocerca gregaria, which are invasive in several European countries. Non-native orthopterans can react very positively to climate warming, resulting in expanding geographical distributions. Furthermore, the number of invasive orthopterans in Europe is likely higher due to a paucity of assessments, increasing introduction rates, and observable impacts on agriculture as well as native species. While e.g., the Migratory LocustLocusta migratoriacauses large-scale damage to crops by forming swarms, the southern oak bush cricketMeconema meridionalehas a negative impact on native species, but neither species is listed as invasive. Besides this, there are other non-native Orthoptera species that could become invasive given increasing reproduction rates due to suitable conditions. Globalization and rising temperatures due to global warming are both increasing introduction rates and concomitantly the availability of suitable locations for reproduction, successful establishments, and finally swarm building. This will increase the probability of damages to agriculture, thus the economy and native biodiversity, eventually endangering human well-being. It is therefore important to monitor and study the invasiveness and impacts of non-native Orthoptera species to develop efficient management or preventive mitigation strategies.