bluuebunny/crossref_metadata_2025_split huggingface dataset:
Синергізм взаємодії культурфілософських аспектів постнекласичного знання у змісті вищої мистецької освіти
Authors: Ткач Марія 
Published: January 2023

У статті здійснений дослідницький пошук культурфілософських аспектів постнекласичного знання у змісті вищої мистецької освіти. Для більш глибокого розуміння зазначених процесів проведений системний теоретичний аналіз етапності розвитку наукового знання і типів наукової раціональності відповідно до усталеної періодизації у філософії науки: класика – некласика – постнекласика. З’ясовано, що феномен раціональності є унікальним рефлексивно-понятійним принципом культури, який її впорядковує, надає їй цілісності та уможливлює раціоналізацію елементів культури в системі освіти.Констатовано, що модель знання у межах класичної парадигми з її багатовіковою культурною традицією мислення не відповідає викликам та реаліям сучасного світу. У фокусі сучасного постнекласичного знання з’являються нові характеристики професійного світорозуміння особистості: «нелінійсть», «нестійкість», «нестабільність», «самоорганізація», «становлення», які забезпечуються новим методологічним інструментарієм синергетики як міждисциплінарним науковим напрямом. У зв’язку з цим, в освіту прийшло розуміння необхідності нових професійних орієнтацій, оскільки в професіограму сучасного фахівця мають закладатися такі характеристики, як адаптивність, гнучкість, креативність, критичне мислення, готовність до змін та ін.У процесі дослідження встановлено, що ідеї синергетики не втратили свого парадигмального значення й до нині. З метою виявлення синергійної взаємодії філософських та культурологічних аспектів постнекласичного знання визначено, що саме міждисциплінарність створює синергетичне підґрунтя для реалізації людиномірного контенту у змісті вищої мистецької освіти, оскільки дисциплінарно побудована університетська освіта, у тому числі й мистецька, суперечить її інноваційності. Тому окреслено напрями реалізації міждисциплінарності у змісті вищої мистецької освіти для формування в студентів цілісного професійного знання у контексті постнекласики.
HUBUNGAN PENGETAHUAN PERAWAT DENGAN KESELAMATAN PASIEN PADA MUTU PELAYANAN KEPERAWATAN
Authors: Arfebi Yoke , Sasmita Fatima Nuraini , Listiana Devi , Dwiana Dian 
Published: January 2023

Keselamatan pasien merupakan salah satu indikator mutu pelayanan keperawatan dimana semakin baiknya keselamatan pasien di rumah sakit,maka semakin baik pula mutu pelayanan keperawatan yang mana semua itu didukung oleh bagaimana pengetahuan perawat terhadap keselamatan pasien. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan perawat dengan keselamatan pasien pada mutu pelayanan keperawatan di ruang rawat inap rumah Sakit Bayangkara Kota Bengkulu. Jenis penelitian ini menggunakan survey anaitik dengan metode Cross Sectional. Populasi dalam penelitian ini adalah perawat yang ada diruang ruang rawat inap rumah sakit ‘’B’’ yag berjumlah 59 orang. Sedangkan pengambilan sampel dalam penelitian ini adalah menggunakan teknik total samplingdan pengumpulan data peneliti menggunakan data primer yaitu berupa kuesioner. Teknik analisis data dengan analisi univariat dan bivariate menggunakan uji chi-square (χ2) dan uji statistik Contingency Coefficient (C). Hasil penelitian Dari 59 perawat terdapat 50 perawat (84.7%) pengetahuan baik dan 32 perawat (54.2%) yang menyatakan keselamatan pasien tinggi keselamatan pasien rendah. Terdapat hubungan yang signifikan antara pengetahuan perawat dengan keselamatan pasien pada mutu pelayanan keperawatan di ruang rawat inap rumah Sakit Bayangkara Kota Bengkulu. Diharapkan kepada pihak Rumah Sakit ‘’B’’ terus meningkatkan aspek empati, responsiveness, assurance dan petugas yang memberikan perhatian lebih kepada pasien untuk kesembuhannya.
PREDIKTOR LAMA RAWATAN PASIEN COVID-19 MELALUI PARAMETER BIOMARKER DI RUMAH SAKIT UMUM HAJI MEDAN TAHUN 2020-2021
Authors: Kurnia M Agung , Nababan Donal , Irennius Girsang Vierto , Siagan Mindo Tua , Tarigan Frida 
Published: January 2023

Tujuan Penelitian ini adalah untuk mengetahui prediktor lama rawatan pasien COVID-19 melalui parameter biomarker di Rumah Sakit Umum Haji Medan tahun 2020-2021. Penelitian ini merupakan penelitian analitik dengan desain kohort restrospektif. Data didapat dengan menggunakan rekam medis pasien terdiagnosis COVID-19 yang dirawat di Rumah Sakit Umum Haji Medan. Instrumen penelitian adalah Rekam medis pasien COVID-19 di Rumah Sakit Umum Haji Medan. Populasi dalam penelitian adalah semua rekam medis pasien terkonfirmasi COVID-19 yang dirawat di Rumah Sakit Umum Haji Medan selama periode waktu tahun 2020 sampai 2021, penelitian menggunakan metode total sampel dan terdapat 711 sampel. Hasil penelitian dari 711 pasien COVID 19 yang menjalani rawat Inap selama tahun 2020 – 2021 di Rumah Sakit Umum Haji Medan provinsi Sumatera Utara didapatkan 144 (20.3%) pasien menjalani lama rawat inap yaitu 7 hari. Dari hasil analisis Univariat di dapatkan rata-rata kadar biomarker pasien yang di rawat inap di Rumah Sakit Umum haji Medan yaitu Hemoglobin 12.7 (g/dL), Eritrosit 4.67 (juta/uL), Trombosit 266 (ribu/mm3), Leukosit 9.8 (ribu/mm3), Limfosit 44 (%), Basofil 0.8 (%), Neutrofil 39 (%), D Dimer 1449 (ug/mL), dan Gula Darah 130.65 (mg/dL). Dari hasil Analisis Bivariat dapatkan bahwa terdapat hubungan antara leukosit dengan nilai (p = 0,002) dan neutrophil dengan nilai (p = 0.013) dimana nilai ini lebih kecil dari (<0,05) yang menunjukkan ada hubungan antara kedua variable dengan lama rawatan pasien COVID 19. Dari hasil analisis Multivariat di dapatkan Biomarker seperti Hemoglobin, Eritrosit, Trombosit, Leukosit, Limfosit, Basofil, Neutrofil, Prokalsitonin, D Diimer dan gula darah memiliki nilai signifikansi (>0.05). Kesimpulan tidak terdapat pengaruh biomarker dengan lama rawatan pasien COVID 19 di rumah sakit Umum Haji Medan.
Pola Kombinasi Genotip Gen BMP2 Rs235768 A>T Pada Kejadian Celah Bibir Dan Atau Palatum Non Sindromik
Authors: Sosiawan Agung , Kurniati Mala , Pramono RM Coen 
Published: January 2023

Celah bibir dengan atau tanpa palatum (CB/P) adalah suatu kondisi deformitas orofasial yaitu terbentuknya pembukaan atau celah yang tidak wajar pada bibir atau palatum. Sekitar 70% CB/P yang terjadi di populasi adalah non sindromik (NS). Tujuan penelitian ini yaitu mengetahui pola kombinasi genotip gen BMP2 rs235768 A>T pada keluarga pasien CB/P. Sampel DNA yang berhasil diamplifikasi dan direstriksi sebanyak 5 sampel keluarga yang terdiri dari ayah, ibu dan anak dengan kelainan CB/P. Berdasarkan analisis dengan menggunakan enzim restriksi dan software program Finch TV dan Bioedit, penelitian ini mengidentifikasi adanya perubahan basa A men­jadi basa T yang merupakan missense mutasi (Serin – Arginin/TCA-TCT). Dari hasil pemetaan pada gen BMP2 rs235768 A>T menunjukkan kelima keluarga memiliki kombinasi yang berbeda-beda. Hal yang menarik pada keluarga ke - 3, kombinasi ayah bergenotip AA (Homozigot/common) dan ibu bergenotip TT (Homozigot/uncommon), memiliki anak ke -3 bergenotip AA (Homozigot/common) dengan kelainan CP (Palatoschizis incomplete). Kombinasi genotip yang mungkin dapat terjadi pada anak dari keluarga 4 yaitu 50 % bergenotip AT (Heterozigot), 50% bergenotip TT (Homozigot/uncommon). Kejadian CB/P tidak hanya melibatkan satu faktor keturunan yang berasal dari satu atau kedua orang tua, tetapi suatu kondisi yang bersamaan. Kelainan CB/P yang terjadi pada anak perempuan, diprediksi risiko kekambuhan pada anak berikutnya jauh lebih tinggi.
Ventricular Unloading Using the ImpellaTM Device in Cardiogenic Shock
Authors: Attinger-Toller Adrian , Bossard Matthias , Cioffi Giacomo Maria , Tersalvi Gregorio , Madanchi Mehdi , Bloch Andreas , Kobza Richard , Cuculi Florim 
Published: January 2023

Graphical AbstractCentral illustration. Design principles and hemodynamic effects of the Impella™ device. AOP, Aortic pressue; EDP, Enddiastolic pressure; EDV, Enddiastolic volume.
Incidence of adverse cardiovascular events associated with immune checkpoint inhibitors and risk factors for left ventricular dysfunction: A single-center prospective clinical study
Authors: Zhang Chuan , Chen Zhulu , Qin Shu , Zhu Yuxi , Shu Linjie , Zuo Zhong 
Published: January 2023

BackgroundThe incidence of immune checkpoint inhibitors (ICI)-related adverse cardiovascular events (ACEs) may be underestimated, and there are few reports on the incidence and risk factors of ICI-induced left ventricular dysfunction (LVD).ObjectivesThis study aimed to investigate the incidence of ACEs caused by ICI, in particular to analyze the incidence and risk factors of LV systolic and diastolic dysfunction.Materials and methodsA prospective clinical study was performed on patients who received ICI in our hospital from November 2020 to October 2021. They received regular cardiovascular examinations, including echocardiography, ECG, cTnT, and NT-proBNP, etc. The incidence of various ACEs was counted, and the risk factors of LVD were analyzed.ResultsA total of 106 cancer patients treated with ICI were recruited. During the follow-up, 41 patients (38.68%) developed various ECG abnormalities, 39 patients (36.79%) developed LVDD, 9 patients (8.49%) developed CTRCD, and 2 patients (1.89%) developed new pericardial effusion. The patients with elevated cTnT, CK-MB, and NT-proBNP were 10 (9.43%), 8 (7.55%), and 8 (7.5%), respectively. Thirteen of the 52 patients with LVD had hypertension, while 4 of the 54 patients without LVD had hypertension (OR = 4.17, 95% CI: 1.26–13.78; P = 0.019). The baseline LVEF and LVFS of patients with LVD were 61.54 ± 4.15% and 33.78 ± 2.73%, while those of the control group were 64.16 ± 3.68% and 34.95 ± 2.84, respectively (P = 0.003 and P = 0.048). Compared with patients without LVD, patients with LVD had lower e’ (6.99 ± 1.33 cm/s vs. 7.64 ± 1.39 cm/s, P = 0.029) and higher E to e’ ratio (11.89 ± 3.15 cm/s vs. 10.43 ± 2.52, P = 0.024). Multiple regression analysis showed that a history of hypertension (HR = 26.52, 95% CI: 2.479–283.667, P = 0.007) and lower baseline e’ (HR = 0.04, 95% CI: 0.003–0.709, P = 0.028) were risk factors for developing LVD.ConclusionPatients treated with ICI may develop multiple ACEs, including acute myocarditis, pericarditis, ECG abnormalities, and elevated cardiac biomarkers. ICI may lead to a high incidence of LVD, and echocardiography is helpful for early detection of LVD. Patients with hypertension or poor LV systolic or diastolic function at baseline were predictors of LVD after ICI treatment.
Practical role of preoperative echocardiography in low-risk non-cardiac surgery
Authors: Kim Eun Kyoung , Choi Hong-Mi , Lee Jong-Hwan , Han Dong Woo , Lee Hye Sun , Choi Eui-Young 
Published: January 2023

BackgroundDue to increased needs to reduce non-fatal as well as fatal cardiac events, preoperative echocardiography remains part of routine clinical practice in many hospitals. Data on the role of preoperative echocardiography in low-risk non-cardiac surgery (NCS) other than ambulatory surgeries do not exist. We aimed to investigate the role of preoperative echocardiography in predicting postoperative adverse cardiovascular events (CVEs) in asymptomatic patients undergoing low-risk NCS.MethodsThe study population was derived from a retrospective cohort of 1,264 patients who underwent elective low-risk surgery at three tertiary hospitals from June 1, 2021, to June 30, 2021. Breast, distal bone, thyroid, and transurethral surgeries were included. Preoperative examination data including electrocardiography, chest radiography, and echocardiography were collected. The primary outcome was a composite of postoperative adverse CVEs including all-cause death, myocardial infarction, cerebrovascular events, newly diagnosed or acutely decompensated heart failure (HF), lethal arrhythmia such as sustained ventricular tachycardia/fibrillation, and new-onset atrial fibrillation within 30 days after the index surgery.ResultsPreoperative echocardiography was performed in 503 patients (39.8%), most frequently in patients with breast surgery (73.5%), followed by transurethral (37.7%), distal bone (21.6%), and thyroid surgeries (11.9%). Abnormal findings were observed in 5.0% of patients with preoperative echocardiography. Postoperative adverse CVEs occurred in 10 (0.79%) patients. Although a history of previous HF was an independent predictor of postoperative CVE occurrence (adjusted odds ratio, aOR: 17.98; 95% confidence interval, CI: 1.21–266.71, P = 0.036), preoperative echocardiography did not significantly predict CVE in multivariate analysis (P = 0.097). However, in patients who underwent preoperative echocardiography, the presence of abnormal echocardiographic findings was independently associated with development of CVE after NCS (aOR: 23.93; 95% CI: 1.2.28–250.76, P = 0.008). In particular, the presence of wall motion abnormality was a strong predictor of postoperative adverse CVE.ConclusionIn real-world clinical practice, preoperative echocardiography was performed in substantial number of patients with potential cardiac risk even in low-risk NCS, and abnormal findings were independently associated with postoperative CVE. Future studies should identify patients undergoing low-risk NCS for whom preoperative echocardiography would be helpful to predict adverse CVE.
Temporal distribution characteristics of earthquakes in Taiwan, China
Authors: Xu Weijin , Li Xuejing , Gao Mengtan 
Published: January 2023

The characteristics of seismic temporal distribution represent an important basis for earthquake prediction and seismic hazard analysis. In this paper, based on the seismic catalogs in Taiwan, and using Poisson (exponential distribution), Gamma, Lognormal, Weibull, and Brownian passage time distributions as target models, we adopt the maximum likelihood method for estimating model parameters. The optimal model for describing the temporal distribution of earthquakes in Taiwan is determined according to the Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC), K-S test, Chi-square test, and coefficient of determination R2 results. The results show that for moderate-strong earthquakes events (MW &lt; 7.0), the Gamma distribution model can well describe the temporal distribution characteristics of earthquakes, while large earthquakes (MW ≥ 7.0) can be described entirely by exponential distribution. In addition, the temporal correlation between earthquakes is also examined through diffusion entropy analysis. The results show that seismic activity features temporal correlation, and earthquakes with relatively small magnitude (MW &lt; 7) are affected by larger events (MW ≥ 7.0), thus suggesting long-term memory in time. In this study, the probability of the occurrence of a major earthquake in Taiwan is also calculated. The results show that the probability of an MW ≥ 7.0 earthquake in Taiwan in the next 10 years reaches 91.3%. The results may be used to inform the selection of seismic time distribution models and the calculation of seismic activity parameters in earthquake prediction and seismic hazard calculation, and hold scientific significance for understanding the mechanism of earthquake genesis.
Papillary Thyroid Microcarcinoma: A Nomogram Based on Clinical and Ultrasound Features to Improve the Prediction of Lymph Node Metastases in the Central Compartment
Authors: Ye Jing , Feng Jia-Wei , Wu Wan-Xiao , Hu Jun , Hong Li-Zhao , Qin An-Cheng , Shi Wei-Hai , Jiang Yong 
Published: January 2023

BackgroundAccurate preoperative identification of central lymph node metastasis (CLNM) is essential for surgical protocol establishment for patients with papillary thyroid microcarcinoma (PTMC). We aimed to develop a clinical and ultrasound characteristics-based nomogram for predicting CLNM.MethodsOur study included 399 patients who were pathologically diagnosed with PTMC between January 2011 and June 2018. Clinical and ultrasound features were collected for univariate and multivariate analyses to determine risk factors of CLNM. A nomogram comprising the prognostic model to predict the CLNM was established, and internal validation in the cohort was performed. The Cox regression model was used to determine the risk factors for recurrence-free survival (RFS) and cumulative hazard was calculated to predict prognosis.ResultsThree variables of clinical and US features as potential predictors including sex (odd ratio [OR] = 1.888, 95% confidence interval [CI], 1.160-3.075; P =0.011), tumor size (OR = 1.933, 95% CI, 1.250-2.990; P =0.003) and ETE (OR = 6.829, 95% CI, 3.250-14.350; P &lt;0.001) were taken into account. The predictive nomogram was established by involving all the factors above used for preoperative prediction of CLNM in patients with PTMC. The nomogram showed excellent calibration in predicting CLNM, with area under curves (AUC) of 0.684 (95% CI, 0.635 to 0.774). Furthermore, tumor size, multifocality, presence of ETE, vascular invasion, and CLNM were the significant factors related to the RFS.ConclusionThrough this easy-to-use nomogram by combining clinical and US risk factor, the possibility of CLNM can be objectively quantified preoperatively. This prediction model may serve as a useful clinical tool to help clinicians determine an individual’s risk of CLNM in PTMC, thus make individualized treatment plans accordingly.
Engineered column treatment of greywater using raw and pyrolyzed coconut husk powder
Authors: Taylor Theodora Sophia , Appiah-Effah Eugene , Akodwaa-Boadi Kofi , Obeng Ernest , Ofei-Quartey Muriel Naa Lamiokor 
Published: January 2023

Reclaimed water from wastewater has become a prominent water source option to manage water scarcity. This study explores the potential of coconut husk biomass, a common waste material in Ghana, as a valuable low-cost resource for greywater treatment. Engineered column treatment was applied to investigate the influence of pyrolysis and biochar properties of coconut husk biomass waste on greywater treatment. Coconut husk biomass waste was pyrolyzed at 600°C and characterized using SEM, FTIR, and XRD. Three engineered columns with 1) raw coconut husk powder (RCHP), 2) charred coconut husk powder (CCHP), and 3) sand-gravel filters (control setup) were used. A hydrostatic head of greywater with a throughput of 8.0 ml/min and a hydraulic retention time of 45 min was maintained for engineered columns. The SEM image suggested an increased surface area and pores due to the pyrolysis of the husk biomass. RCHP and CCHP contributed to 63% and 95% turbidity removal, respectively. Experimental results showed high removal efficiencies of 71% COD for CCHP. The nitrate removal efficiency of 78.93%, 88.38%, and 28.65% was observed for RCHP, CCHP, and control respectively. The log removal of faecal coliform by CCHP was two orders of magnitude higher than RCHP. Faecal and total coliform removal was 2.87 log units for CCHP. Significant differences were observed between CCHP and RCHP, p &lt; 0.05 for electrical conductivity and total dissolved solids of effluents. CCHP showed a promising potential for greywater treatment. Pyrolyzed coconut husk powder is a promising adsorbent applicable to greywater treatment.
Exploring the Italian equine gene pool via high-throughput genotyping
Authors: Capomaccio Stefano , Ablondi Michela , Colombi Daniele , Sartori Cristina , Giontella Andrea , Cappelli Katia , Mancin Enrico , Asti Vittoria , Mantovani Roberto , Sabbioni Alberto , Silvestrelli Maurizio 
Published: January 2023

Introduction: The Italian peninsula is in the center of the Mediterranean area, and historically it has been a hub for numerous human populations, cultures, and also animal species that enriched the hosted biodiversity. Horses are no exception to this phenomenon, with the peculiarity that the gene pool has been impacted by warfare and subsequent “colonization”. In this study, using a comprehensive dataset for almost the entire Italian equine population, in addition to the most influential cosmopolitan breeds, we describe the current status of the modern Italian gene pool.Materials and Methods: The Italian dataset comprised 1,308 individuals and 22 breeds genotyped at a 70 k density that was merged with publicly available data to facilitate comparison with the global equine diversity. After quality control and supervised subsampling to ensure consistency among breeds, the merged dataset with the global equine diversity contained data for 1,333 individuals from 54 populations. Multidimensional scaling, admixture, gene flow, and effective population size were analyzed.Results and Discussion: The results show that some of the native Italian breeds preserve distinct gene pools, potentially because of adaptation to the different geographical contexts of the peninsula. Nevertheless, the comparison with international breeds highlights the presence of strong gene flow from renowned breeds into several Italian breeds, probably due to historical introgression. Coldblood breeds with stronger genetic identity were indeed well differentiated from warmblood breeds, which are highly admixed. Other breeds showed further peculiarities due to their breeding history. Finally, we observed some breeds that exist more on cultural, traditional, and geographical point of view than due to actual genetic distinctiveness.
Seroprevalence of hepatitis C virus infection in patients with type 2 diabetes mellitus is associated with increased age in sub-Saharan Africa: Results from a cross-sectional comparative analysis
Authors: Feutseu Charly , Kowo Mathurin Pierre , Boli Anne Ongmeb , Katte Jean Claude , Guewo-Fokeng Magellan , Zemsi Sylvain , Dehayem Mesmin Yefou , Choukem Simeon Pierre , Sobngwi Eugene 
Published: January 2023

BackgroundSeveral epidemiological studies have established the association between hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM). However, the determinants and reasons for the high prevalence of HCV infection in people with T2DM are not well understood especially in sub-Saharan African populations. In this study, we aimed to assess determinants of the association between HCV infection and T2DM.MethodsWe performed a cross-sectional study amongst 442 T2DM patients recruited from an out-patient adult diabetes clinic in a tertiary hospital and 442 non-diabetic controls recruited from the general population. Serological testing for HCV antibody was performed using standard ELISA technique. Anti-HCV antibody prevalence was reported by age group in participants with diabetes and the non-diabetic controls. Logistic regression was used to examine for factors associated with the HCV infection in patients with diabetes.ResultsWe reported an overall HCV prevalence of 11.5% [95% CI: 9.4-13.6] irrespective of diabetes status in this study. The seroprevalence of HCV infection in diabetics patients was 17.6% [95% CI: 14.0-21.2] compared to 5.5% [95% CI: 3.4-7.6] in non-diabetics (p&lt; 0.001). We did not find a significant HCV seropositivity difference in diabetic patients with common risk factors of HCV infection. When investigating the HCV seroprevalence by age group in diabetic and non-diabetic patients, no case of HCV infection was found in patients less than 30 years old while the highest HCV seropositivity was reported in patients older than 60 years (36.7% T2DM and 11.1% for non-diabetics) followed by the patients belonging to 50-59 years age group (16% in T2DM and 5.8% in non-diabetics) and those in 40-49 years age group (4.4% in diabetic, 0.8% in non-diabetic). To support this finding, in a multivariate logistic regression, only diabetic patients belonging to age group &gt; 65 years had a significant risk (OR: 16.7 [95% CI: 1.7-160.0]) to acquire HCV infection.ConclusionThe seroprevalence of HCV infection is higher among T2DM adult patients than in non-diabetic patients, and is associated with increased age. This age-dependent association may suggest a generational exposure that may no longer exist overtime.