bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential Correction versus Conventional Correction for Severe and Rigid Kyphoscoliosis: A Retrospective Case Control Study
Authors: Hua Wenbin , Ke Wencan , Li Shuai , Feng Xiaobo , Wang Kun , Yin Huipeng , Wu Xinghuo , Zhang Yukun , Gao Yong , Ling Li , Yang Cao 
Published: September 2023

ObjectiveConventional correction techniques were challenging and of high risk of neurological complications for the correction of severe and rigid kyphoscoliosis. A new technical note we developed and named as sequential correction, was used to treat severe and rigid kyphoscoliosis. The present study was to compare the clinical outcomes of sequential correction versus conventional correction for the treatment of severe and rigid kyphoscoliosis.MethodsThis is a respectively case–control study. Between January 2014 and December 2019, 36 adults underwent the surgical correction of severe and rigid kyphoscoliosis and were included in the present study. Among them, 20 adults underwent conventional correction, 16 adults underwent sequential correction. Major curve Cobb angle, kyphotic angle, coronal imbalance, and sagittal vertical axis were compared between two groups. The patient‐reported health‐related quality of life outcomes, including the Oswestry disability index score, and SRS‐22 questionnaire, were recorded. Independent samples t‐test, Mann–Whitney U test, and Wilcoxon signed‐rank test, were used to compare the differences between two groups according to the results of normal distribution test.ResultsIn conventional correction group, the mean major curve Cobb angle was 122.50° preoperatively, 40.35° immediately after surgery, and 43.95° at final follow‐up postoperatively; the mean kyphotic angle was 97.45° preoperatively, 34.45° immediately after surgery, and 38.30° at final follow‐up postoperatively. In the sequential correction group, the mean major angle was 134.44° preoperatively, 44.56° immediately after surgery, and 46.25° at final follow‐up postoperatively; the mean kyphotic angle was 112.31° preoperatively, 39.00° immediately after surgery, and 40.38° at final follow‐up postoperatively. The mean major curve Cobb angle and kyphotic angle of both groups were improved significantly, while there were no significant differences between two groups (p > 0.001). Improved self‐reported quality of life scores were achieved postoperatively and at final follow‐up postoperatively, and there were no significant differences between the two groups. The total complication rate of the patients underwent conventional correction was 55%, and the total complication rate of the patients underwent sequential correction was 43.75%. The complication rate of the two groups showed no significant difference.ConclusionsSequential correction is an excellent and safe treatment for severe and rigid kyphoscoliosis in adults, with similar clinical outcomes with conventional correction. The total complication rate of the patients who underwent sequential correction was slightly lower than conventional correction.
Novices’ professional identification awakened: Uncovering the impact of positive profession‐spotlighting events
Authors: Wu Wei , Liu Wu , Wu Wen , Xia Yuhuan 
Published: September 2023

AbstractMany professions experience unique events that highlight their relevance and value. These positive profession‐spotlighting events may significantly influence employees’ professional identification, especially for novices in the highlighted professions. In this paper, we aim to gain a comprehensive understanding of this phenomenon. Drawing on the identity construction process model, we investigate how and why positive profession‐spotlighting events influence novices’ professional identification. In Study 1, using 10‐wave longitudinal data (five waves before and five after the outbreak of COVID‐19) collected from 322 new graduate nurses, we use discontinuous growth modeling to investigate the impact of the pandemic as a positive profession‐spotlighting event on their increase in professional identification. We found that new graduate nurses’ professional identification gradually fell during their initial months in professional practice but rose dramatically after the onset of COVID‐19. We also found that sensegiving and moral elevation during the event led to an increase in professional identification. We further theorize an increase in work meaningfulness as the core mechanism for the hypothesized relationships and obtain supporting evidence from one experiment (Study 2) and two quasi‐experiments (Studies 3a and 3b). Our research reveals the significant influence of positive profession‐spotlighting events on both the identity construction and socialization processes and offers practical implications for how to manage such events.
Stop the blame game: An analysis of blaming on Weibo during the early days of the COVID‐19 pandemic in rice and wheat areas in China
Authors: Wang Shuang , English Alexander S. , Deng Yue , Zhou Ye Zi , Buchtel Emma E. 
Published: September 2023

AbstractIn the pandemic era, social media has provided the public with a platform to make their voice heard. One of the most important public opinions online during a pandemic is blame. Blame can lead to stigma towards patients as well as potential patients and decrease social cooperation, which might impede prevention and control measures during epidemics. Thus, studying online blame during the early days of COVID‐19 can facilitate the management and control of future pandemics. By analyzing 3791 posts from one of the most popular social media sites in China (Weibo) over the 10 days immediately after COVID‐19 was declared to be a communicable disease, we found that there were four main agents blamed online: Individuals, corporations, institutions, and the media. Most of the blame targeted individual agents. We also found that there were regional‐cultural differences in the detailed types of blamed individual agents, that is, between rice‐ and wheat‐farming areas in China. After controlling influence of distance from the epicenter of Wuhan, there were still stable differences between regions: people in wheat areas had a higher probability of blaming agentic, harmful individuals, and people in rice areas had a higher probability of blaming individuals with low awareness of social norms for preventive health behavior. Findings have implications for preventing and predicting blame across cultures in future pandemics.
The Effect of Ignition Procedure on Flashback of Hydrogen-Enriched Flames
Authors: Yahou Tarik , Schuller Thierry , Dawson James R. 
Published: September 2023

Abstract
The impact of different ignition sequences on the ignition dynamics of CH4-H2 flames in a bluff body burner is investigated at atmospheric conditions. Experiments are performed over a wide range of operating conditions covering pure methane injection (PH0) to pure hydrogen injection (PH100). A perforated plate of total porosity σ=0.17 is positioned at the outlet of the combustion chamber to increase the chamber back pressure and trigger transient flashback during ignition. Time-series of pressure, OH* chemiluminescence and OH-PLIF images of the propagating flame branch are recorded simultaneously to characterize the ignition process. Two ignition procedures are investigated. For ignition procedure A, designated as an early ignition procedure, the spark is initiated before fuel injection. For ignition procedure B, designated as a late ignition, the spark is only activated after the fuel injection. The impact of the fuel air mixing on the final stabilization state is investigated by changing the fuel delivery time (dt) before the initial spark. Three different time delays are considered dt = 1, 3, and 5 s. The final state of the flame is found to be highly sensitive to the selected ignition procedure and increasing dt favors the occurrence of flashback. At constant power, the magnitude of the pressure peak is driven by a competition between the fuel mass flowrate at the moment of ignition and the high reactivity of hydrogen, which shifts the flammability limit toward lower equivalence ratios, hence generating a lower reaction rate. For procedure A, the peak of the chamber over pressure shows a nonmonotonic growth for increasing levels of H2 in the fuel blend, while it linearly increases for procedure B. Experiments are then conducted at a fixed injection flow velocity Ub = 5 m s–1 and fixed laminar burning velocity Sl0=0.25 m s–1 by varying the level of hydrogen enrichment. For procedure A, the over pressure amplitude decreases with increasing the hydrogen enrichment leading to a soft ignition for all CH4-H2 blends. Under ignition procedure B, the amplitude of the over pressure reached during ignition is found to be relatively unaffected by the hydrogen concentration, but the flame stabilization mode shows a strong dependence to both the level of H2-enrichment and fuel delivery time dt. OH* as well as OH-PLIF images reveal that the trajectory of the flame leading point changes as dt increases. The different dynamics of the flame leading points is likely to be the cause the different types of stabilization modes observed.
3D Printed Gyroid Elastomer and Silicone Composite for Controlled Anisotropy Simulating Human Tissue
Authors: Li Yu M. , Chen Po-Han , Paracuellos Raphaelle , Morris Karcher , Makale Milan , Mayadev Jyoti , Talke Frank E. 
Published: September 2023

Abstract
This paper proposes a novel design approach for a composite emulating the strain hardening and anisotropic mechanical characteristics of normal and abnormal vaginal tissue. The realized composite consisted of a soft elastomeric silicone matrix integrated with a thermoplastic polyurethane 3D scaffold. The strain-hardening effect of vaginal tissue was attained by altering the scaffold’s gyroid structure. As the composite deformed, the mechanical response changed from silicone-dominated to polyurethane-dominated. The anisotropic properties of the composite were created by introducing anisotropy in the gyroid structure to replicate the effects of various collagen fiber orientations in vaginal tissue. Changes in mechanical behavior were quantified using uniaxial tensile testing. Three types of distorted gyroids were examined, x-axis lengthened, y-axis lengthened, and x and y-axis lengthened unit cells.
Modal Analysis and Static Structure Analysis for 3-Axis Cartesian Robot Used in Injection Molding Machine
Authors: Fan Chen-Wei , Tu Tse-Yi , Chen Chih-We 
Published: September 2023

Abstract
This study implemented the experimental and theoretical modal analysis of the cartesian robot used in injection molding machines. The experimental modal analysis was calculated with CADA PC, and the theoretical modal analysis was studied based on the finite element method with COMSOL. To verify the rigidity strength and modal shape of the original structural design of its 3-axis cartesian robot. At the same time, build a finite element model of the robot which is validated using the modal parameters of experimental analysis. Structural diagnosis based on modes shape and resonance vibration results was carried out; structural design would be improved and the feasibility of replacing new materials would be assessed. Under the same load, the robotic arm could be lightened, or the load intensity could be increased, which can achieve the advantages of low power consumption, small size, and increased loading volume.
Near-complete genome sequence of human astrovirus recovered from a child with acute flaccid paralysis in Guinea, 2021
Authors: Kèbè Ousmane , Thiaw Fatou Diène , Ndiaye Ndack , Landoh Dadja Essoya , Cissé Gassim , Faye Ousmane , Faye Martin 
Published: September 2023

ABSTRACT
Astroviruses are common causes of gastroenteritis in humans and other animals. Herein, we reported a near-complete human astrovirus (HAstV) sequence detected in a child with acute flaccid paralysis. The sample was collected in Guinea in January 2021. Phylogenetic analyses indicated that this virus belonged to the HAstV-1 genotype.
Draft genome sequences of a historical collection of
Listeria monocytogenes
from humans and other sources, 1926–1964
Authors: Brown Phillip , Murray Robert G. E. , Galsworthy Sara , Ivanova Mirena , Leekitcharoenphon Pimlapas , Ward Todd , Kucerova Zuzana , Chen Yi , Elhanafi Driss , Siletzky Robin , Kathariou Sophia 
Published: September 2023

ABSTRACT

Listeria monocytogenes
can persistently contaminate food processing environments and tolerate sanitizers. Most sequenced strains are from clinical and environmental sources in the contemporary era, with relatively few prior to extensive food processing and sanitizer use. We report the genome sequences of a diverse panel of 83 strains from 1926 to 1964.
Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations
in vivo
Authors: Wang Sihan , Zhang Tian-hao , Hu Menglong , Tang Kejun , Sheng Li , Hong Mengying , Chen Dongdong , Chen Liubo , Shi Yuan , Feng Jun , Qian Jing , Sun Lifeng , Ding Kefeng , Sun Ren , Du Yushen 
Published: September 2023

ABSTRACT

Neuraminidase (NA) is a pivotal surface enzyme and a key therapeutic target in combating the influenza A virus. Its evolution can lead to potential zoonotic transmission, seasonal epidemics, and the emergence of drug-resistant mutants. To gain comprehensive insights into the mutational effects and drug resistance profiles of NA, we employed a high-throughput profiling system to quantify the replication capacity of NA mutants at the single-nucleotide level in mouse lung tissues. The fitness of NA mutants is generally correlated with natural mutation occurrence and is constrained by both the requirement to maintain protein stability and NA function. Leveraging this system, we profiled the drug resistance to the three most commonly used neuraminidase inhibitors (NAIs): zanamivir, oseltamivir, and peramivir. In addition to identifying previously reported drug resistance mutations, we validated novel mutants. Notably, we identified an allosteric mutation that confers resistance to all three drugs, which may affect drug binding by interfering with the tetramerization of NA. Moreover, the fitness cost associated with drug-resistant mutations may limit their widespread dissemination. In summary, we provided a parallel characterization of NA’s fitness and drug resistance landscape in an
in vivo
context, which may guide the rational selection of antiviral drugs for optimal therapeutic efficacy and second-generation NAI development.

IMPORTANCE

NA is a crucial surface antigen and drug target of influenza A virus. A comprehensive understanding of NA’s mutational effect and drug resistance profiles
in vivo
is essential for comprehending the evolutionary constraints and making informed choices regarding drug selection to combat resistance in clinical settings. In the current study, we established an efficient deep mutational screening system in mouse lung tissues and systematically evaluated the fitness effect and drug resistance to three neuraminidase inhibitors of NA single-nucleotide mutations. The fitness of NA mutants is generally correlated with a natural mutation in the database. The fitness of NA mutants is influenced by biophysical factors such as protein stability, complex formation, and the immune response triggered by viral infection. In addition to confirming previously reported drug-resistant mutations, novel mutations were identified. Interestingly, we identified an allosteric drug-resistance mutation that is not located within the drug-binding pocket but potentially affects drug binding by interfering with NA tetramerization. The dual assessments performed in this study provide a more accurate assessment of the evolutionary potential of drug-resistant mutations and offer guidance for the rational selection of antiviral drugs.
A description of the genus
Denitromonas
nom. rev.:
Denitromonas iodatirespirans
sp. nov., a novel iodate-reducing bacterium, and two novel perchlorate-reducing bacteria,
Denitromonas halophila
and
Denitromonas ohlonensis
, isolated from San Francisco Bay intertidal mudflats
Authors: Reyes-Umana Victor M. , Coates John D. 
Published: September 2023

ABSTRACT

The genus
Denitromonas
is currently a non-validated taxon that has been identified in several recent publications as members of microbial communities arising from marine environments. Very little is known about the biology of
Denitromonas
spp., and no pure cultures are presently found in any culture collections. The current epitaph of
Denitromonas
was given to the organism under the assumption that all members of this genus are denitrifying bacteria. This study performs phenotypic and genomic analyses on three new
Denitromonas
spp. isolated from tidal mudflats in the San Francisco Bay. We demonstrate that
Denitromonas
spp. are indeed all facultative denitrifying bacteria that utilize a variety of carbon sources such as acetate, lactate, and succinate. In addition, individual strains also use the esoteric electron acceptors perchlorate, chlorate, and iodate. Both 16S and Rps/Rpl phylogenetic analyses place
Denitromonas
spp. as a deep branching clade in the family
Zoogloeaceae
, separate from either
Thauera
spp.,
Azoarcus
spp., or
Aromatoleum
spp. Genome sequencing reveals a G + C content ranging from 63.72% to 66.54%, and genome sizes range between 4.39 and 5.18 Mb. Genes for salt tolerance and denitrification are distinguishing features that separate
Denitromonas
spp. from the closely related
Azoarcus
and
Aromatoleum
genera.

IMPORTANCE

The genus
Denitromonas
is currently a non-validated taxon that has been identified in several recent publications as members of microbial communities arising from marine environments. Very little is known about the biology of
Denitromonas
spp., and no pure cultures are presently found in any culture collections. The current epitaph of
Denitromonas
was given to the organism under the assumption that all members of this genus are denitrifying bacteria. This study performs phenotypic and genomic analyses on three
Denitromonas
spp.,
Denitromonas iodatirespirans
sp. nov.—a novel iodate-reducing bacterium—and two novel perchlorate-reducing bacteria,
Denitromonas halophila
and
Denitromonas ohlonensis
, isolated from San Francisco Bay intertidal mudflats.
Economic Benefits from Restoration Actions in Coastal Communities
Authors: Melstrom Richard T. , Hyink Jillian 
Published: September 2023

In this study, we measure the effect of restoration actions on the economic value of coastal communities. We use a residential sorting model to simulate residential moves between communities and then estimate the value of restoring shoreline uses in coastal communities. Our application measures the effect of cleaning up Great Lakes Areas of Concern (AOC) — which are heavily polluted coastal locations prioritized for restoration in the United States and Canada — on the willingness to pay (WTP) of residents in the U.S. state of Michigan. While prior research documents the effect of individual AOCs on residents, particularly in local housing markets, little research has examined systematically where restoration is occurring and whether it affects mobility at a regional level. The results in this paper suggest that restoration actions can affect mobility, with point estimates indicating households are willing to pay $54/year for the uses restored between 2005 and 2015 in Michigan’s AOCs.
Data-Sharing Markets: Model, Protocol, and Algorithms to Incentivize the Formation of Data-Sharing Consortia
Authors: Castro Fernandez Raul 
Published: September 2023

Organizations that would mutually benefit from pooling their data are otherwise wary of sharing. This is because sharing data is costly-in time and effort-and, at the same time, the benefits of sharing are not clear. Without a clear cost-benefit analysis, participants default in not sharing. As a consequence, many opportunities to create valuable data-sharing consortia never materialize, and the value of data remains locked.
We introduce a new sharing model, market protocol, and algorithms to incentivize the creation of data-sharing markets. The combined contributions of this paper, which we call DSC, incentivize the creation of data-sharing markets that unleash the value of data for its participants. The sharing model introduces two incentives; one that guarantees that participating is better than not doing so and another that compensates participants according to how valuable their data is. Because operating the consortia is costly, we are also concerned with ensuring its operation is sustainable: we design a protocol that ensures that a valuable data-sharing consortium forms when it is sustainable.
We introduce algorithms to elicit the value of data from the participants, which is used first to cover the costs of operating the consortia and second to compensate for data contributions. For the latter, we challenge using the Shapley value to allocate revenue. We offer analytical and empirical evidence for this and introduce an alternative method that compensates participants better and leads to the formation of data-sharing consortia.
Metabolic Hallmarks for Purine Nucleotide Biosynthesis in Small Cell Lung Carcinoma
Authors: Tabata Sho , Umemura Shigeki , Narita Miyu , Udagawa Hibiki , Ishikawa Takamasa , Tsuboi Masahiro , Goto Koichi , Ishii Genichiro , Tsuchihara Katsuya , Ochiai Atsushi , Kobayashi Susumu S. , Soga Tomoyoshi , Makinoshima Hideki 
Published: September 2023

Abstract

Small cell lung cancer (SCLC) has a poor prognosis, emphasizing the necessity for developing new therapies. The de novo synthesis pathway of purine nucleotides, which is involved in the malignant growth of SCLC, has emerged as a novel therapeutic target. Purine nucleotides are supplied by two pathways: de novo and salvage. However, the role of the salvage pathway in SCLC and the differences in utilization and crosstalk between the two pathways remain largely unclear. Here, we found that deletion of the HPRT1 gene, which codes for the rate-limiting enzyme of the purine salvage pathway, significantly suppressed tumor growth in vivo in several SCLC cells. We also demonstrated that HPRT1 expression confers resistance to lemetrexol (LMX), an inhibitor of the purine de novo pathway. Interestingly, HPRT1-knockout had less effect on SCLC SBC-5 cells, which are more sensitive to LMX than other SCLC cell lines, suggesting that a preference for either the purine de novo or salvage pathway occurs in SCLC. Furthermore, metabolome analysis of HPRT1-knockout cells revealed increased intermediates in the pentose phosphate pathway and elevated metabolic flux in the purine de novo pathway, indicating compensated metabolism between the de novo and salvage pathways in purine nucleotide biosynthesis. These results suggest that HPRT1 has therapeutic implications in SCLC and provide fundamental insights into the regulation of purine nucleotide biosynthesis.

Implications:
SCLC tumors preferentially utilize either the de novo or salvage pathway in purine nucleotide biosynthesis, and HPRT1 has therapeutic implications in SCLC.
Soundscapes of a Century: The Art and Transmission of Irish Broadcasting’s 100-Year Milestone
Authors: Eadie Jimmy 
Published: September 2023

Abstract
This article examines two renditions of an artwork titled 100, which celebrate a historic radio transmission in 1916 during the Irish war for independence. The centenary artwork delves into the concept of radio transmission as an artistic expression rather than solely a practical function. The work explores the intersection of radio transmission with installation art, as well as its connections to sound art and sound design. Engaging with diverse theoretical frameworks, the article interrogates the boundaries of radio and its relationship with other media expressions. It also seeks to understand important historical works and events within radio, with a focus on exploring the roots of radio and its history in Ireland.