bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Embolization in Recurrent Hemoptysis Caused by Pulmonary Aspergilloma: A Case Report
Authors: Yaman Muli , Sugiri Jane , Putra Ngakan , Santosaningsih Dewi , Aslam Achmad 
Published: March 2023

Background: Aspergilloma is a fungal infection that can cause recurrent hemoptysis. One of the treatment modalities is embolization, which has a success rate of 85% to 100%, although the recurrence rate may reach 10% to 33%.
Case Illustration: A 29-year-old female came to the emergency ward with recurrent hemoptysis. She had a history of tuberculosis with completed treatment 7 years ago. Chest radiography showed left lung tuberculosis with emphysematous lung. Chest CT with contrast revealed an air-crescent sign, and culture from bronchoalveolar lavage (BAL) showed Aspergillus spp. Then, she was diagnosed with pulmonary aspergilloma. Embolization was performed in the left internal mammary artery, and the blushing was decreased by 80%. However, the hemoptysis was still recurrent; a second embolization was performed in the left supreme intercostal artery, costocervical trunk artery, and bronchial artery, resulting in no blushing. The patient had no further episodes of hemoptysis, and her antifungal therapy was changed from fluconazole to voriconazole.
Discussion: Recurrent hemoptysis can be caused by pulmonary aspergilloma. Embolization is usually done to reduce bleeding before surgery. The patient had performed embolization 2 times with no further episodes of hemoptysis. Surgical resection as a definitive treatment was recommended in this case, but the patient refused. Therefore, the patient’s management was optimized using voriconazole and embolization for the hemoptysis.
Conclusion: Management of recurrent hemoptysis in patients with aspergilloma may include embolization and antifungal treatment which give improved clinical outcomes.
Keywords: recurrent hemoptysis, embolization, aspergilloma, tuberculosis
Severe Abdominal Pain Due To Gastrointestinal Obstruction in Patient With Lung Adenosquamous Metastases in Colon
Authors: Zata Dini  , Pratiwi Suryanti , Setyawan Ungky , Budianto Aries , Yudhanto Hendy , Erawati Dini 
Published: March 2023

Background: Lung cancer is the most common cause of cancer-related death globally. Moreover, metastatic cancer from the lungs frequently occurs and is commonly identified at the first diagnosis. The primary cancer must be identified in order to establish the most effective treatment. However, colonic metastases are rare with incidence of 0,1%.
Aim: This report describes an unusual case of colonic metastases from lung adenocarcinoma.
Methods: Patient (58-year-old male) was examined with Fiber Optic Bronchoscopy and core biopsy in the lungs, and the results were suspicious for squamous cells. The patient had severe abdominal pain and bloating for 1 week and had signs of gastrointestinal obstruction in his second visit. The result of urgent laparotomy was adenosquamous and the result of immunohistochemical examination was negative P40 and positive Napsin A in both lungs and colon.
Results: The lung biopsy result indicated squamous cell and the ceccum showed adenosquamous. The immunohistochemical examination using P40 and Napsin A of both lung and ceccum specimens indicated that the lung was the primary source of metastases to the colon.
Conclusion: The patient suffered from a squamous cell lung tumor and reported severe abdominal pain due to metastases to the colon with adenosquamous results.
Silk Fibroin Hydrogel-Assisted Controlled Release of Antifungal Drug Ketoconazole
Authors: Roy Tomal Chandro , Ansary Rezaul Haque , Biswas Protyasha , Haider Md Ali 
Published: March 2023

This research focused on preparing a ketoconazole-infused silk fibroin hydrogel to enhance patient compliance, leveraging the hydrogel's biocompatibility and biodegradability. The process used a 50% (v/v) ethanol, propanol, or glycerol solution treated with 2% (w/v) silk fibroin at 37°C. The use of glycerol quickened the gelation process. The hydrogel's structure was analyzed via SEM, and UV-VIS spectrometry was used to evaluate the encapsulation efficiency and ketoconazole release profile. The surface structure varied based on the formulation and the best encapsulation efficiency was observed with ethanol (60±1.78%), followed by propanol (56±2.72%) and glycerol (47±1.42%). The release profile demonstrated an initial burst release followed by 20 hours of sustained release. Furthermore, the hydrogel-encapsulated drug demonstrated effective antifungal activity against Aspergillus Niger. As a result, silk fibroin hydrogels are a promising option for controlled topical delivery of ketoconazole.
Keywords: Silk fibroin, Controlled release, Hydrogels, Drug delivery.
Teacher Perspective: Managing Students’ Behavior Problem in Teaching English at Primary School
Authors: Humaeroah Humaeroah , Sardi Ahmed , Ermawati Ermawati 
Published: March 2023

This research is aimed to discover about students’ behaviors problem that teacher faced in language classroom that may occur in language teaching and learning process at primary schools. The objectives of the research are to find out how to manage students’ behaviors problem at primary schools, especially in EFL classroom. This research used a descriptive qualitative research design. This research took ten English teachers in primary school as the participants of the research which were been taken through purposive sampling. The data of this research was collected by interview and audio recorder. The research findings show seven category of managing students behavior problem applied by the teachers in the English classroom , they are: positive relationships are developed and maintained between teacher and students, seating arrangement, encourage active learning, encourage experience-based learning, applying ICT in learning, support and strategy, the last is giving punishment. The ability of teachers to organise and manage classroom behaviours of their students is critical to achieving the learning objectives. Although behavioural management does not guarantee effective teaching, it makes improvement possible.
The Benefits and Drawbacks of Kahoot: Students’ Perspective
Authors: Bhuana Gartika Pandu 
Published: March 2023

Technology and education are inseparable. Many schools or universities have integrated the use of technology in the classroom. The purpose is not only to bring the effectiveness of in the teaching, but also to enhance students’ motivation and participation in learning. Kahoot is one of the educational online games that is mostly used by the teacher. Unfortunately, some students think that there are problems on its usage. This study is intended to investigate the benefits and the drawbacks of Kahoot from students’ perspective. The descriptive qualitative method was considered suitable to be used. There were 50 students at one institution selected as the participants of the study. The data were collected through questionnaire and interview. Overall findings revealed that most of the students had positive attitude to the implementation of Kahoot. It offered the advantages and condition that could not be offered in conventional method. For example, it provided positive competitiveness and lively atmosphere in the class. However, some drawbacks were found. It was dealt with technical problem, such as internet connection, and the absence of discussion, and the frequency of its usage. Finally, it is suggested for the second language lecture to consider some aspects in the implementation of Kahoot.
Pengaruh Berbagai Metode Ekstraksi dari Ekstrak Etanol Umbi Bawang Tiwai (Eleutherine americana Merr) terhadap Rendemen Ekstrak dan Profil Kromatografi Lapis Tipis
Authors: Mawarda Ayida , Samsul Erwin , Sastyarina Yurika 
Published: March 2023

The bulb of Eleutherine americana Merr is a typical Kalimantan plant that has many medicinal properties. Many studies have been carried out with various extraction methods used to determine the compounds contained in the bulb of Eleutherine americana Merr. This study aims to determine the effect of the method and the extraction time on the yield value and thin layer chromatography profile (TLC) of the bulb of Eleutherine americana Merr extract. The extraction method uses 96% ethanol solvent using the maceration method for 2 weeks and ultrasonic bath method with time variables of 10, 20 and 30 minutes. The yield of maceration extract was 12% and the ultrasonic bath method was 12.5%, 17.5%, and 15% (10, 20, 30 minutes). In the TLC test there were no differences in the spot patterns of the two extraction methods. So it can be concluded that the extraction method affects the yield of extract but does not affect the extract compound content seen from the TLC spot pattern.
The Features of the Circle of Willis on Multislice Computed Tomography in Humans Without Cerebral Vascular Malformations
Authors: Van Ngoc Doan , Anh Tuan Tran , Dinh Au Hoang 
Published: March 2023

Abstract: A study of 135 cases without cerebral vascular malformations who were scan MSCT of cerebral arteries at Bach Mai hospital during the period from January 2019 to December 2019. Result: mean diameter of cerebral artery segments: left and right A1 segments: 2.28 ± 0.47 and 2.19 ± 0.53 mm; AcomA: 1.71 ± 0.68 mm; left and right M1 segments: 2.82 ± 0.46 mm and 2.8 ± 0.49 mm; left and right PcomA: 1.62 ± 0.5 mm and 1.67 ± 0.48 mm; left and right P1 segments: 2.22 ± 0.49 mm and 2.22 ± 0.56 mm; left and right P2 segments: 2.32 ± 0.38 mm and 2.35 ± 0.36 mm; BA: 3.41 ± 0.69 mm. The diameters of the cerebral arteries were similar in both sexes, with no difference on the right and left sides of the ring of Willis. The diameter of the edges of the Willis circle varied from aplastic and hypoplastic, which was mainly seen in the AcomA, PcomA, the A1 segment of the anterior cerebral artery, and P1 of the posterior cerebral artery. The transformations of the Willis ring included 17 forms, of which four simple transformations of the anterior part, four simple transformations of the posterior part, and nine combined transformations between the anterior and posterior parts. Mainly found aplasia or hypoplasia of the AcomA 14.1% and the PcomA 12.6%. Conclusion: the index of normalization of the segments of the Willis polygon and its variant forms contributed to bolder intervention planning in cerebrovascular disease treatment.
Keywords: Circle of Willis, Cerebral arteries, MSCT.
Analysis of Drug Procurement Results in Vietnam from 2013 to 2020
Authors: Thi Hai Yen Nguyen , Hiep Phung The , Thi My Dung Nguyen , Danh Le Ngoc , Ngan Thai Hue , Nguyen Le Dang Tu 
Published: March 2023

Abstract: Drug procurement bidding has always been under the government’s particular concern to assure drug quality, stabilize drug costs, and enhance the use of domestic drugs. A retrospective study analyzes data from the drug procurement results in Vietnam from 2013 to 2020 based on the results reported to the Drug Administration of Vietnam. The rate of drugs selected through the bidding process in Hanoi and HCMC accounted for the highest proportion in the country with 17.5% and 14.3%, respectively. The number of selected drugs with domestic origins had seen a gradual increase over the years with 4545 drugs during 2020, which was 2.2 times higher than that of 2013 (2079 drugs). Generic drugs in group 3 with domestic origins comprised the highest proportion of both quantity and value compared to drugs in other groups. Antiparasitic drugs and anti-infectives had the highest value rates among pharmacological groups with over 20%. During the research period, the costs of selected drugs tended to witness a decreasing trend, accounting for 60% of drugs. Only 9% of the drugs had their values remain unchanged, and the other 31% saw an increase in these values. State bidding procurement policies are making positive effects in lowering drug costs and encouraging domestic drug use. However, the value rate of domestic drugs is still lower than that of imported ones. It is necessary for domestic pharmaceutical enterprises to invest in developing factories, actively find domestic ingredient sources, and focus on specific medications in great demand.
Keywords: Drug bidding, drug price, generic bidding package, original brand name bidding package, period of 2013-2020, Vietnam.
Towards Developing Quantitative Structure-activity Relationship Models for the Design of Novel Influenza A Inhibitors Targeting Neuraminidase
Authors: Thanh Ly Cong 
Published: March 2023

Abstract: Anti-influenza-A drugs targeting viral neuraminidase have been in use for two decades. In this study, the quantitative structure-activity relationships (QSAR) of oseltamivir derivatives as influenza neuraminidase (IN) inhibitors have been explored using the Monte Carlo method based on the target function involving the index of the ideality of correlation. Three best-obtained models showed appropriate performance with R2 values of training and test sets ranging from 0.71 to 0.86, respectively. Based on the structural information extracted from the models, new inhibitors were designed and predicted for IN activities. Finally, protein docking was applied to confirm their target binding ability.
Keyword: Anti-influenza A; neuramidase inhibitor; drug design; QSAR; docking.
In Vivo Bioequivalence Study of Drug: An Analysis of Related Regulations in Current Pharmaceutical Legislation in Vietnam
Authors: Quoc Hung Tang , Thanh Hai Nguyen , Bich Ngoc Tran 
Published: March 2023

Abstract: Implementation of in vivo bioequivalence study is a growing trend in the pharmaceutical industry in Vietnam and over the world. These studies are required in order to demonstrate whether a generic drug is a bioequivalence to an innovator’s drug or to an original brand name drug. At present, there are 26 active ingredients that have to provide in vivo bioequivalence study report for drug registration in Vietnam. In the next few years, this number will gradually increase. Therefore, the government should introduce promotion, development, and preferential policies for enterprises to invest in these ingredients. This paper aims to provide general guidelines on regulations of in vivo bioequivalence studies for pharmaceutical enterprises in Vietnam and support the initial implementation of these studies in practice.
Keywords: Bioequivalence, BABE, BE, Regulations.
Investigation of Lyophilized Microspheres Loaded with Leuprolide Acetate
Authors: Thanh Lam Nguyen , Giao Thong Ngo , Thi My Duyem Tran , Thi Thuong Bui , Thi Hai Yen Tran 
Published: March 2023

Abstract: Leuprolide acetate (LA) - a nonapeptide, used for the treatment of some hormone-depending diseases, is unstable and very susceptible to degradation in the aqueous media. Poly (lactic-co-glycolic) acid (PLGA) is a copolymer of lactide and glycolide, that has generated tremendous interest in pharmaceutics because of their excellent biocompatibility, biodegradability, and mechanical strength. PLGA is used for the preparation of biocompatible biodegradable extended-release microspheres. However, the PLGA undergoes hydrolytic degradation in an aqueous environment through cleavage of its backbone ester linkages. As a consequence, PLGA-based microspheres loaded with LA are usually lyophilized to ensure the stability of LA and PGLA and reduce agglomeration, sedimentation, and size change of microspheres during storage. The aim of this present study is to evaluate the influence of lyoprotectants namely mannitol, trehalose, lactose, and saccharose on the stability of LA and characteristics of PLGA-based microspheres loaded with LA upon lyophilization. DSC and FTIR were used to evaluate the biocompatibility of LA and lyoprotectants. The results showed that there was no incompatibility between the LA and lyoprotectants. Mannitol solution 1.25% was used in freeze-drying PLGA-based microspheres loaded with LA. The obtained lyophilized microspheres had a good appearance and low moisture. Lyophilized microspheres after reconstitution had no significant change in drug content, size, and size distribution in comparison to that before freeze-drying.
Keywords: Leuprolide acetate, PGLA, lyophilized, stability, biodegradable microspheres.
Research on the Preparation of Self-nano-emulsifying Drug Delivery System Containing Gynostemma pentaphyllum Dry Extract for Application in Skin Care Cosmetics
Authors: Giang Vu Thi Thu , Thuy Hanh Pham , Van Lam Nguyen 
Published: March 2023

Abstract: Gynostemma pentaphyllum (Thunb.) Makino is a rich source of the herb in Vietnam. The gypenosides in this herb are triterpenoid saponins that have been shown to have moisturizing, antioxidant, and anti-aging effects on the skin. However, gypenosides are hydrophilic and have a large molecular weight with a bulk molecular structure which prevents them from penetrating and absorbing into the skin. To apply the natural active ingredients from herbs into skin care cosmetics, this research developed self-nano-emulsifying drug delivery systems (SNEDDS) containing Gynostemma pentaphyllum dry extract and applied them to emulgel skin care cosmetics. Prepared SNEDDS could self-emulsify in the water to form nanoemulsions with dispersed droplet sizes less than 20 nm with PDI < 0.3. The proportion of saponin entrapped in the oil droplets of nano emulsification was more than 90%. When combined with emulgel excipients, the obtained cosmetic products had nano-sized dispersed droplets less than 200 nm with uniform droplet size distribution, which are promising for application when further research is carried out.
Keywords: Self-nano-emulsifying Drug Delivery System (SNEDDS), Gymnostemma pentaphyllum dry extract, cosmetic, emulgel, nano-emulsion.
Evaluation of Protein Kinase C Inhibition of some Benzofuro[3,2-d]pyrimidine Derivatives
Authors: Thi Van Anh Tran , Thanh Hoa Ha , Quoc Tuan Pham , Thi Sau Ngo , Mai Huong Do , Van Thang Nguyen , Van Thao Tran , Thanh Hai Nguyen , Viet Hung Dao 
Published: March 2023

Abstract: Treatment of fungal infections is very difficult because of the limited therapeutic arsenal and the emergence of resistance to the two major antifungal classes: azoles and echinocandins. Consequently, finding new targets and new therapeutic strategies is a priority. The protein kinase Pkc1 of Candida albicans (CaPkc1), one of the key proteins involved in MAPK pathways, is described as a regulator of cell wall integrity during growth, morphogenesis, and response to cell wall stress. Therefore, the discovery of CaPkc1 inhibitory molecules can open up new and promising prospects in the development of new antifungal drugs that inhibit CaPkc1. In this study, we evaluated the CaPkc1 inhibitory activity of three benzofuro[3,2-d]pyrimidine derivatives at three different concentrations of 50 µM, 100 µM, and 150 µM. A concentration of 100 μM was optimal for CaPkc1 inhibitory activity with all three benzofuro[3,2-d]pyrimidine derivatives.
Keywords: Benzofuro[3,2-d]pyrimidine, CaPkc1, Candida albicans, antifungal activity.
Methadone Maintenance Therapy after Aneurysmal Subarachnoid Hemorrhage: A Case Report
Authors: Smith Austin , Cook Aaron , Hatton Kevin 
Published: March 2023

There is limited information on the effects of continued methadone maintenance therapy following aneurysmal subarachnoid hemorrhage (aSAH). However, with the increasing incidence of opioid use disorder (OUD) in the US, there is a need to define best practices for the management of pain and prevention of acute withdrawal syndrome in patients with pre-existing OUD who develop aSAH. In this case report, we describe the use of MMT in a patient with aSAH and discuss important considerations, including sedation or confusion that might mimic acute neurologic changes seen in cerebral vasospasm or delayed cerebral ischemia, cardiac complications related to QTc prolongation, and liver or kidney interactions associated with aSAH routine treatment. Our patient recovered from her aSAH without any adverse events and, with increased monitoring and collaborative team-based care, including input from those with expertise in OMD or aSAH, we believe MMT can be safely continued in most aSAH patients.
Psychological attitudes of Indonesian millenials consumer to choose Islamic banking financing
Authors: Santoso Moh. Herman Eko , Nurzaman Mohamad Soleh 
Published: March 2023

Islamic banks define as financial service institutions which offer the ease of owning home through Islamic homeownership financing products as knows as Islamic mortgage. This financing product can be a solution for millennials to be able to own a home. This study aims to examine the psychological response of millennials generation towards acceptance in choosing an Islamic mortgage using Theory of Planned Behavior Model (TPB) with Attitude, Subjective Norm, and Perceived Behavioral Control as variables. Analyzed of 256 respondents in this study used Structural Equation Modelling AMOS (SEM-AMOS) and IBM SPSS Statistics. The research shows that the variable Attitude and Perceived Behavioural Control have positive and significant impact on the intention of millennials to choose Islamic mortgage. Further, Perceived Behavioral Control was found to be the most influential factor in determining the intention of millennials to choose Islamic mortgage. On the other hand, this study also found that the Subjective Norm variable had a positive but not significant for the effect. These findings provide information that psychological factors can form the customer's intention to use Islamic mortgage products. Therefore, all stakeholders can consider the psychological factors of prospective customers in designing and developing Islamic mortgage products in Indonesia.
proposta para o ensino de geometria espacial
Authors: Santos Maria Graciene Moreira , Alves Francisco Régis Vieira , Lima Francisco José de 
Published: March 2023

Dadas as dificuldades dos estudantes na compreensão de figuras tridimensionais quando esboçadas no plano bidimensional em sala de aula, como o quadro ou lousa branca, vimos a necessidade de propor este estudo. O trabalho tem como objetivo apresentar uma proposta didática para a introdução do ensino de sólidos de revolução com o aporte do software GeoGebra, norteada pelas dialéticas da Teoria das Situações Didáticas. Como metodologia, adotamos a Engenharia Didática em suas duas primeiras fases – análises preliminares e análise a priori - dado o fato de que este é um trabalho em andamento. Como resultados trazemos uma construção que pode ser utilizada pelo professor para explorar conceitos geométricos de área e da visualização da passagem de figuras 2D para 3D, estimulando a visualização geométrica do estudante por meio da manipulação de comandos no GeoGebra. Desse modo, busca-se colaborar com a prática do professor de matemática. Este estudo é fruto de uma pesquisa em andamento realizada no curso de Pós-graduação em Ensino de Ciências e Matemática (PGECM), logo, almejamos desenvolver esta construção em sala de aula e continuar as duas fases posteriores da Engenharia Didática, com coleta de dados empíricos.