bluuebunny/crossref_metadata_2025_split huggingface dataset:
The future of software-controlled cooking
Authors: Blutinger Jonathan David , Cooper Christen Cupples , Karthik Shravan , Tsai Alissa , Samarelli Noà , Storvick Erika , Seymour Gabriel , Liu Elise , Meijers Yorán , Lipson Hod 
Published: March 2023

AbstractTo date, analog methods of cooking such as by grills, cooktops, stoves and microwaves have remained the world’s predominant cooking modalities. With the continual evolution of digital technologies, however, laser cooking and 3D food printing may present nutritious, convenient and cost-effective cooking opportunities. Food printing is an application of additive manufacturing that utilizes user-generated models to construct 3D shapes from edible food inks and laser cooking uses high-energy targeted light for high-resolution tailored heating. Using software to combine and cook ingredients allows a chef to more easily control the nutrient content of a meal, which could lead to healthier and more customized meals. With more emphasis on food safety following COVID-19, food prepared with less human handling may lower the risk of foodborne illness and disease transmission. Digital cooking technologies allow an end consumer to take more control of the macro and micro nutrients that they consume on a per meal basis and due to the rapid growth and potential benefits of 3D technology advancements, a 3D printer may become a staple home and industrial cooking device.
Photon bound state dynamics from a single artificial atom
Authors: Tomm Natasha , Mahmoodian Sahand , Antoniadis Nadia O. , Schott Rüdiger , Valentin Sascha R. , Wieck Andreas D. , Ludwig Arne , Javadi Alisa , Warburton Richard J. 
Published: March 2023

AbstractThe interaction between photons and a single two-level atom constitutes a fundamental paradigm in quantum physics. The nonlinearity provided by the atom leads to a strong dependence of the light–matter interface on the number of photons interacting with the two-level system within its emission lifetime. This nonlinearity unveils strongly correlated quasiparticles known as photon bound states, giving rise to key physical processes such as stimulated emission and soliton propagation. Although signatures consistent with the existence of photon bound states have been measured in strongly interacting Rydberg gases, their hallmark excitation-number-dependent dispersion and propagation velocity have not yet been observed. Here we report the direct observation of a photon-number-dependent time delay in the scattering off a single artificial atom—a semiconductor quantum dot coupled to an optical cavity. By scattering a weak coherent pulse off the cavity–quantum electrodynamics system and measuring the time-dependent output power and correlation functions, we show that single photons and two- and three-photon bound states incur different time delays, becoming shorter for higher photon numbers. This reduced time delay is a fingerprint of stimulated emission, where the arrival of two photons within the lifetime of an emitter causes one photon to stimulate the emission of another.
Predicting outcomes of continuous renal replacement therapy using body composition monitoring: a deep-learning approach
Authors: Yoo Kyung Don , Noh Junhyug , Bae Wonho , An Jung Nam , Oh Hyung Jung , Rhee Harin , Seong Eun Young , Baek Seon Ha , Ahn Shin Young , Cho Jang-Hee , Kim Dong Ki , Ryu Dong-Ryeol , Kim Sejoong , Lim Chun Soo , Lee Jung Pyo ,   Korean Association for the Study of Renal Anemia and Artificial Intelligence (KARAI), Kim Sung Gyun , Ko Gang Jee , Park Jung Tak , Chang Tae Ik , Chung Sungjin , Lee Jung Pyo , Lee Sang Ho , Choi Bum Soon , Jeon Jin Seok , Song Sangheon , Choi Dae Eun , Jung Woo Kyung 
Published: March 2023

AbstractFluid balance is a critical prognostic factor for patients with severe acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). This study evaluated whether repeated fluid balance monitoring could improve prognosis in this clinical population. This was a multicenter retrospective study that included 784 patients (mean age, 67.8 years; males, 66.4%) with severe AKI requiring CRRT during 2017–2019 who were treated in eight tertiary hospitals in Korea. Sequential changes in total body water were compared between patients who died (event group) and those who survived (control group) using mixed-effects linear regression analyses. The performance of various machine learning methods, including recurrent neural networks, was compared to that of existing prognostic clinical scores. After adjusting for confounding factors, a marginal benefit of fluid balance was identified for the control group compared to that for the event group (p = 0.074). The deep-learning model using a recurrent neural network with an autoencoder and including fluid balance monitoring provided the best differentiation between the groups (area under the curve, 0.793) compared to 0.604 and 0.606 for SOFA and APACHE II scores, respectively. Our prognostic, deep-learning model underlines the importance of fluid balance monitoring for prognosis assessment among patients receiving CRRT.
Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers
Authors: Hillebrand Arjan , Holmes Niall , Sijsma Ndedi , O’Neill George C. , Tierney Tim M. , Liberton Niels , Stam Anine H. , van Klink Nicole , Stam Cornelis J. , Bowtell Richard , Brookes Matthew J. , Barnes Gareth R. 
Published: March 2023

AbstractMagneto- and electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG systems the sensors are offset from the scalp, which limits the signal-to-noise ratio (SNR) and thereby the sensitivity to activity from deep structures such as the hippocampus. This effect is amplified in children, for whom adult-sized fixed-helmet systems are typically too big. Moreover, ictal recordings with fixed-helmet systems are problematic because of limited movement tolerance and/or logistical considerations. Optically Pumped Magnetometers (OPMs) can be placed directly on the scalp, thereby improving SNR and enabling recordings during seizures. We aimed to demonstrate the performance of OPMs in a clinical population. Seven patients with challenging cases of epilepsy underwent MEG recordings using a 12-channel OPM-system and a 306-channel cryogen-based whole-head system: three adults with known deep or weak (low SNR) sources of interictal epileptiform discharges (IEDs), along with three children with focal epilepsy and one adult with frequent seizures. The consistency of the recorded IEDs across the two systems was assessed. In one patient the OPMs detected IEDs that were not found with the SQUID-system, and in two patients no IEDs were found with either system. For the other patients the OPM data were remarkably consistent with the data from the cryogenic system, noting that these were recorded in different sessions, with comparable SNRs and IED-yields overall. Importantly, the wearability of OPMs enabled the recording of seizure activity in a patient with hyperkinetic movements during the seizure. The observed ictal onset and semiology were in agreement with previous video- and stereo-EEG recordings. The relatively affordable technology, in combination with reduced running and maintenance costs, means that OPM-based MEG could be used more widely than current MEG systems, and may become an affordable alternative to scalp EEG, with the potential benefits of increased spatial accuracy, reduced sensitivity to volume conduction/field spread, and increased sensitivity to deep sources. Wearable MEG thus provides an unprecedented opportunity for epilepsy, and given its patient-friendliness, we envisage that it will not only be used for presurgical evaluation of epilepsy patients, but also for diagnosis after a first seizure.
Interchange of Southern Hemisphere humpback whales across the South Atlantic Ocean
Authors: Ramos Eric Angel , Cheeseman Ted , Marcondes Milton Cesar C. , Olio Marilia , Vogel Alexander , Elwen Simon , de Melo Thais H. M. , Facchola Cecília , Cipolotti Sérgio , Southerland Ken , Findlay Ken , Seyboth Elisa , McCue Steven A. , Kotze Pieter G. H. , Seakamela S. Mduduzi 
Published: March 2023

AbstractThe cosmopolitan distribution of humpback whales (Megaptera novaeangliae) is largely driven by migrations between winter low-latitude breeding grounds and summer high-latitude feeding grounds. Southern Hemisphere humpback whales faced intensive exploitation during the whaling eras and recently show evidence of population recovery. Gene flow and shared song indicate overlap between the western (A) and eastern (B1, B2) Breeding Stocks in the South Atlantic and Indian Oceans (C1). Here, we investigated photo-identification evidence of population interchange using images of individuals photographed during boat-based tourism and research in Brazil and South Africa from 1989 to 2022. Fluke images were uploaded to Happywhale, a global digital database for marine mammal identification. Six whales were recaptured between countries from 2002 to 2021 with resighting intervals ranging from 0.76 to 12.92 years. Four whales originally photographed off Abrolhos Bank, Brazil were photographed off the Western Cape, South Africa (feeding grounds for B2). Two whales originally photographed off the Western Cape were photographed off Brazil, one traveling to the Eastern Cape in the Southwestern Indian Ocean (a migration corridor for C1) before migrating westward to Brazil. These findings photographically confirm interchange of humpback whales across the South Atlantic and Indian Oceans and the importance of international collaboration to understand population boundaries.
Dynamic changes to signal allocation rules in response to variable social environments in house mice
Authors: Miller Caitlin H. , Hillock Matthew F. , Yang Jay , Carlson-Clarke Brandon , Haxhillari Klaudio , Lee Annie Y. , Warden Melissa R. , Sheehan Michael J. 
Published: March 2023

AbstractUrine marking is central to mouse social behavior. Males use depletable and costly urine marks in intrasexual competition and mate attraction. We investigate how males alter signaling decisions across variable social landscapes using thermal imaging to capture spatiotemporal marking data. Thermal recording reveals fine-scale adjustments in urinary motor patterns in response to competition and social odors. Males demonstrate striking winner-loser effects in scent mark allocation effort and timing. Competitive experience primes temporal features of marking and modulates responses to scent familiarity. Males adjust signaling effort, mark latency, and marking rhythm, depending on the scent identities in the environment. Notably, recent contest outcome affects how males respond to familiar and unfamiliar urine. Winners increase marking effort toward unfamiliar relative to familiar male scents, whereas losers reduce marking effort to unfamiliar but increase to familiar rival scents. All males adjust their scent mark timing after a contest regardless of fight outcome, and deposit marks in more rapid bursts during marking bouts. In contrast to this dynamism, initial signal investment predicts aspects of scent marking days later, revealing the possibility of alternative marking strategies among competitive males. These data show that mice flexibly update their signaling decisions in response to changing social landscapes.
First-principles study of square chalcogen bond interactions and its adsorption behavior on silver surface
Authors: Wang Hui , Li Bin , Wang Xiaoting , Yin Fu , Wei Qiaoyu , Wang Xudong , Ni Yuxiang , Wang Hongyan 
Published: March 2023

Square chalcogen bonds are formed by dimers, fluoro-substituted dimers were also considered for comparison. A systematic first-principles investigation of square chalcogen interaction, and its adsorption behavior on Ag surface are presented.
The Development of Left Hemisphere Lateralization for Sentence-Level Prosodic Processing
Authors: Pasquinelli Rennie , Tessier Anne Michelle , Karas Zachary , Hu Xiaosu , Kovelman Ioulia 
Published: March 2023

Purpose:
The fine-tuning of linguistic prosody in later childhood is poorly understood, and its neurological processing is even less well studied. In particular, it is unknown if grammatical processing of prosody is left- or right-lateralized in childhood versus adulthood and how phonological working memory might modulate such lateralization. Furthermore, it is virtually unknown how prosody develops neurologically among children with cochlear implants (CIs).

Method:
Normal-hearing (NH) children ages 6–12 years and NH adults ages 18–28 years completed a functional near-infrared spectroscopy neuroimaging task, during which they heard sentence pairs and judged whether the sentences did or did not differ in their overall prosody (declarative, question, with or without narrow focus). Children also completed standard measures of expressive and receptive language.

Results:
Age group differences emerged; children exhibited stronger bilateral temporoparietal activity but reduced left frontal activation. Furthermore, children's performance on a nonword repetition test was significantly associated with activation in the left inferior frontal gyrus—an area that was generally more activated in adults than in children.

Conclusions:
The prosody-related findings are generally consistent with prior neurodevelopmental works on sentence comprehension, especially those involving syntax and semantics, which have also noted a developmental shift from bilateral temporal to left inferior frontal regions typically associated with increased sensitivity to sentence structure. The findings thus inform theoretical perspectives on brain and language development and have implications for studying the effects of CIs on neurodevelopmental processes for sentence prosody.

Supplemental Material:

https://doi.org/10.23641/asha.22255996
Analytical modelling of adaptive optics systems: Role of the influence function
Authors: Berdeu Anthony , Tallon Michel , Thiébaut Éric , Langlois Maud 
Published: March 2023

Context.Adaptive optics (AO) is now a tool commonly deployed in astronomy. The real time correction of the atmospheric turbulence that AO enables allows telescopes to perform close to the diffraction limit at the core of their point spread function (PSF). Among other factors, AO-corrected PSFs depend on the ability of the wavefront corrector (WFC), generally a deformable mirror, to fit the incident wavefront corrugations.Aims.In this work, we focus on this error introduced by the WFC, the so-called fitting error. To date, analytical models only depend on the WFC cut-off frequency, and Monte Carlo simulations are the only solution for studying the impact of the WFC influence function shape on the AO-corrected PSF. We aim to develop an analytical model accounting for the influence function shape.Methods.We first obtain a general analytical model of the fitting error structure function. With additional hypotheses, we then derive an analytical model of the AO-corrected power spectral density. These two analytical solutions are compared with Monte Carlo simulations on different ideal profiles (piston, pyramid, Gaussian) as well as with real hardware (DM192 from ALPAO).Results.Our analytical predictions show a very good agreement with the Monte Carlo simulations. We show that in the image plane, the depth of the correction as well as the transition profile between the AO-corrected area and the remaining turbulent halo depend on the influence functions of the WFC. We also show that the generally assumed hypothesis of stationarity of the AO correction is actually not met.Conclusions.As the fitting error is the intrinsic optimal limit of an AO system, our analytical model allows for the assessment of the theoretical limits of extreme AO systems limited by the WFC in high-contrast imaging through a context where other errors become comparable.
Quiet Sun flux rope formation via incomplete Taylor relaxation
Authors: Robinson Rebecca A. , Aulanier Guillaume , Carlsson Mats 
Published: March 2023

Context. Low-altitude nanoflares are among the candidates for atmospheric heating in the quiet Sun’s corona. Low-altitude twisted magnetic fields may be involved in such events, as they are in larger flares. But for nanoflares, the exact role, topology, and formation mechanisms of these twisted fields remain to be studied.
Aims. In this paper, we investigate the formation and evolution of a preflare flux rope in a fully stratified, 3D magnetohydrodynamics simulation of the quiet Sun using the Bifrost code. This study focuses on the time period before the rope eventually reconnects with an overlying field, resulting in a nanoflare-scale energy on the order of 1017 J. One puzzle is that this modeled flux rope does not form by any of the mechanisms usually at work in larger flares, such as flux emergence, flux cancellation, or tether-cutting reconnection.
Methods. Using Lagrangian markers to trace representative field lines, we follow the spatiotemporal evolution of the flux rope. By focusing on current volumes (which we call current sheets) between these lines, we identify flux bundles and associated reconnecting field line pairs. We also analyze the time-varying distribution function for the force-free parameter as the flux rope relaxes. Lastly, we compare different seeding methods for tracing magnetic field lines, and discuss their relevance to the analysis.
Results. We show that the modeled flux rope is gradually built from the coalescence of numerous current-carrying flux tubes. This occurs through a series of component reconnections that are continuously driven by the complex flows in the underlying convection zone. These reconnections lead to an inverse cascade of helicity from small scales to larger scales. We also find that the system attempts to relax toward a linear force-free field, but that the convective drivers and the nanoflare event prevent full Taylor relaxation.
Conclusions. Using a self-consistently driven simulation of a nanoflare event, we show for the first time an inverse helicity cascade tending toward a Taylor relaxation in the Sun’s corona, resulting in a well-ordered flux rope that later reconnects with surrounding fields. This provides context clues toward understanding the buildup of nanoflare events in the quiet Sun through incomplete Taylor relaxations, when no relevant flux emergence or cancellation is observed.
SIRT: Planung, Durchführung, Dosimetrie
Authors: Kästner David , Michler Enrico 
Published: March 2023

ZusammenfassungDie Selektive Interne Radiotherapie (SIRT) ist ein nuklearmedizinisches Therapieverfahren zur Behandlung von Tumoren und Metastasen in der Leber. Dabei werden radioaktiv markierte Mikrosphären gezielt über einen Katheter in die Leberarterie injiziert, welche sich anschließend im Tumorgewebe anreichern. Dieser Übersichtsartikel soll einen Überblick zur allgemeinen Planung und Durchführung der Therapie sowie den derzeitig verfügbaren Mikrosphären geben. Des Weiteren werden die unterschiedlichen Methoden zur Ermittlung der Therapieaktivität unter Berücksichtigung der aktuellen Empfehlungen und Leitlinien der European Association of Nuclear Medicine (EANM) genauer erläutert. Dabei wird der Stellenwert einer personalisierten Dosimetrie diskutiert.
Low Escitalopram Concentrations in Patients with Depression predict
Treatment Failure: A Naturalistic Retrospective Study
Authors: Hart Xenia M. , Amann Friederike , Brand Jonas , Eichentopf Luzie , Gründer Gerhard 
Published: March 2023

Abstract
Introduction Cross sectional therapeutic drug monitoring (TDM) data mining
introduces new opportunities for the investigation of medication treatment
effects to find optimal therapeutic windows. Medication discontinuation has been
proven useful as an objective surrogate marker to assess treatment failure. This
study aimed to investigate the treatment effects of escitalopram and
pharmacokinetic influences on blood levels using retrospectively assessed data
from a TDM database.
Methods Data was collected from 134 patients longitudinally treated with
escitalopram for whom TDM was requested to guide drug therapy. Escitalopram
metabolism was estimated by the log-transformed dose-corrected concentrations
and compared within subpopulations differing in age, gender, renal function,
smoking status, body mass index, and comedication.
Results Patients with a depressive episode who were treated with
escitalopram and discontinued the treatment within the hospital stay showed
lower serum concentrations compared to patients who continued escitalopram
treatment with a concentration of 15 ng/mL separating both
groups. Variability was high between individuals and factors influencing blood
levels, including dose, sex, and age. Comedication that inhibits cytochrome P450
(CYP) 2C19 isoenzymes were further found to influence escitalopram
pharmacokinetics independent of dose, age or sex.
Discussion Medication switch is a valuable objective surrogate marker to
assess treatment effects under real-world conditions. Of note, treatment
discontinuation is not always a cause of insufficient response but may also be
related to other factors such as medication side effects. TDM might not only be
useful in addressing these issues but titrating drug concentrations into the
currently recommended reference range for escitalopram will also increase
response in non-responders and avoid treatment failure in underdosed
patients.
Ergebnisqualität der spezialisierten stationären palliativmedizinischen Komplexbehandlung bei Kindern und Jugendlichen
Authors: Kubek Larissa Alice , Schmidt Pia , Wager Julia , Garske Dörte , Beissenhirtz Andrea , Zernikow Boris 
Published: March 2023

Zusammenfassung
Hintergrund Wichtige Behandlungsziele einer pädiatrischen Palliativstation sind eine Symptomlastreduktion bei Patient:innen sowie eine Verbesserung der Handlungskompetenz der Eltern.
Methodik Mittels des Qualitätssicherungsinstruments QUASI wurden Handlungskompetenz der Eltern sowie Symptomlast und Lebensqualität von Patient:innen bei deren stationärer Aufnahme (Prä) und Entlassung (Post) erfasst.
Ergebnisse Vom 20.10.2020 bis zum 31.12.2022 lagen für n=269 Patient:innen Prä- und Post-Daten vor. In der allgemeinen Symptomausprägung (p=0,004), dem Allgemeinzustand der Kinder (p=0,005), der Lebensqualität der Kinder (p<0,001) und der Familie (p<0,001) sowie in der Skala „Handlungskompetenz der Eltern“ (p<0,001) zeigten sich signifikante Verbesserungen. Patient:innen mit initial hoher Symptomlast zeigten eine signifikante Verbesserung aller erfassten Symptome. Selbst Patient:innen mit initial geringer Symptomlast zeigten in Bezug auf Schmerzen (p=0,002), Schlafstörungen (p<0,001) und „weiterer Symptome“ (p=0,023) eine Verbesserung. In Bezug auf die aktuelle Situation der Familie zeigten sich in allen Bereichen bis auf „Die Familie ist sich sicher, dass sie die richtigen Entscheidungen für ihr Kind trifft“ signifikante Verbesserungen.
Schlussfolgerungen Die Durchführung einer spezialisierten stationären palliativmedizinischen Komplexbehandlung in der Pädiatrie führt zu einer hohen Ergebnisqualität.
Synthesis of the C17–C30 Bis-THF Fragment of Iriomoteolide-13a via Intramolecular syn-Oxypalladation of 26-Ene-17,21,23,28-tetraol
Authors: Dai Wei-Min , Gao Kai , Ma Haichen , Yip Tsz Chun , Zhao Hui 
Published: March 2023

AbstractThe fully substituted C17–C30 bis-tetrahydrofuran fragment of the proposed structure of iriomoteolide-13a has been assembled via asymmetric dihydroxylation-SN2 cyclization of 19-mesyloxy-21-ene-26-yne and PdCl2-catalyzed syn-oxypalladation of 26-ene-17,21,23,28-tetraol as the key steps. The syn-oxypalladation process gave an 89:11 diastereoselectivity and tolerated the free poly-hydroxy groups in the highly functionalized substrate.