bluuebunny/crossref_metadata_2025_split huggingface dataset:
Workforce diversity and financial statement readability
Authors: Li Leye , Lu Louise Yi , Wang Yi , Yu Yangxin 
Published: January 2023

AbstractThe Securities and Exchange Commission has associated readability with a range of linguistic features largely determined by the language style of the information producers, including sentence length and the use of personal pronouns, familiar words, surplus words and active voice. We examine the impact of a firm's workforce ethnic diversity on its financial statement readability. Based on linguistic literature, we argue that a more diverse workforce increases the linguistic heterogeneity of the inputs into financial statements, hindering financial statement readability. We show that financial statement readability decreases with the ethnic diversity of the workforce, and that this effect is more pronounced for firms located in a community with a high crime rate or low social capital. We also find that the market reacts less to the earnings surprises of firms with less readable financial statements. We further find that the impact of white‐collar employee diversity on readability is greater than that of blue‐collar employee diversity. The results of robustness tests suggest that workplace diversity does not reduce firms' overall information production quality, which rules out the alternative explanation that employee diversity hinders financial statement readability through increasing employee conflict and communication errors. Overall, our study suggests that workforce diversity is an important determinant of financial statement readability.
Pupae survival following fire in the frosted elfin (Callophrys irus)
Authors: Meyer Robert T. , Pokswinski Scott M. , Ney Jacob , McElveen Dave 
Published: January 2023

Abstract
The frosted elfin (Callophrys irus) butterfly inhabits landscapes that may be subject to frequent fire to be sustained. Frosted elfins pupate primarily in leaf litter, at the soil surface, or just below it, and may suffer high mortality rates when fires occur. Gathering better information on this source of mortality is critical to planning prescribed fire operations in a manner conducive to the long‐term survival of the species.
We buried lab‐reared frosted elfin pupae (n = 61) at 0.75 cm (n = 31) or 1.75 cm (n = 30) below the ground and conducted two experimental fires that mimicked typical prescribed fires.
Eighteen of 30 (60%) buried at 1.75 cm survived 4 weeks postburn; no pupae buried at 0.75 cm survived. Most (n = 17) of the pupae that survived successfully enclosed the following year. Surviving pupae encountered lower maximum temperatures and were exposed to shorter durations of above‐lethal temperatures compared to those that died.
Our data demonstrate that high mortality rates can be expected due to fire, yet fire remains a critical tool for maintaining the habitat. Fire practitioners should mitigate losses by using ignition patterns and suboptimal burn conditions to reduce fire intensity, or burn in a mosaic pattern across the landscape to ensure enough survival to perpetuate frosted elfin populations.
Current landscape of cancer survivorship research in Australia
Authors: Morris Julia N , Crawford‐Williams Fiona , Koczwara Bogda , Chan Raymond J , Vardy Janette , Lisy Karolina , Iddawela Mahesh , Mackay Gillian , Jefford Michael 
Published: January 2023

AbstractAimResponse to the substantial and long‐term impacts that a cancer diagnosis and treatment has on the growing population of cancer survivors, requires priority‐driven, impactful research. This study aimed to map Australian cancer survivorship research activities to identify gaps and opportunities for improvement and compare activities against identified survivorship research priorities.MethodsAn online survey was completed by Australian researchers regarding their cancer survivorship research, and the barriers they identified to conducting such research. Current research activity was compared to recently established Australian survivorship research priorities.ResultsOverall, 178 participants completed the online survey. The majority of the research undertaken utilized survey or qualitative designs and focused on breast cancer, adult populations, and those in early survivorship (<5 years post‐treatment). Barriers to conducting survivorship research included funding, collaboration and networking, mentoring, and time constraints. There was moderate alignment with existing research priorities. Investigating models of care and health service delivery were the most frequently researched priorities. Research priorities that were less commonly investigated included patient navigation, patient‐reported outcomes, multimorbidity, fear of cancer recurrence, and economic issues.ConclusionThis study provides the first snapshot of Australian survivorship research activity. Comparison to established priorities demonstrates health services research is receiving attention and highlights areas for potential pursuits, such as rare cancers or multimorbidity. Findings indicate the need for improved funding and infrastructure to support researchers in advancing the survivorship research agenda.
Analysis of implants for metastatic bone tumors of the proximal femur: A retrospective study
Authors: Terakawa Fumihide , Kamoda Hiroto , Yonemoto Tsukasa , Hagiwara Yoko , Tsukanishi Toshinori , Kinoshita Hideyuki , Ohtori Seiji , Ishii Takeshi 
Published: January 2023

AbstractAimTo investigate the relationship between surgical techniques used in our hospital to treat metastatic bone tumors of the proximal femur and activity level and prognosis of patients and whether the location of the tumor is considered when selecting surgical techniques.MethodsWe retrospectively reviewed 82 patients with metastatic bone tumors of the proximal femur who underwent intramedullary nail fixation (IMN), bipolar hip arthroplasty (BHP) or modular megaprosthesis (MMP) in our hospital from 2007 to 2020. We measured the distance from the center of femoral head to the proximal (x) and distal (y) end of the of tumor, using preoperative computed tomography images to determine the location of metastasis. We also measured revised Katagiri score at the time of fracture, postoperative ISOLS/MSTS (functional outcome) scores, and overall survival.ResultsThe value of x was significantly different among the three groups. The value of y showed a significant difference between the IMN and BHP groups and the BHP and MMP groups. The functional outcome score was significantly lower in the IMN group. The survival rate of the patient tended to be higher in the BHP and MMP groups than in the IMN group 1 year postoperatively.ConclusionIMN was favored when the distance from the center of femoral head to the proximal end of the tumor was ≥15 mm. In the case of prosthetic replacement, BHP was chosen if the distance from the center of femoral head to the distal end of the tumor was ≤70 mm. BHP and MMP were preferred over IMN functionally.
Risk factors for taxane‐induced peripheral neuropathy in patients with breast cancer
Authors: Liang Cuilv , Zhang Yin , Chen Qi Ying , Chen Wen Fa , Chen Ming Zhu 
Published: January 2023

AbstractPurposeThis study investigated the clinical risk factors for peripheral neuropathy induced by docetaxel and albumin‐bound paclitaxel (AP) in patients with breast cancer.MethodsThis prospective observational study recruited 268 patients between March 2019 and December 2020. Patient information was obtained through the query system for laboratory test results, patient consultations, and scale evaluations. Neuropathic symptoms were followed up throughout and until 3 months after taxane chemotherapy. Univariate and multivariate analyses were used to find the risk factors for overall and moderate–severe taxane‐induced peripheral neuropathy (TIPN).ResultsCumulative dose (odds ratio [OR] = 3.533, 95% confidence interval [CI]: 1.797–6.944, p < 0.001), body mass index (BMI) (OR = 2.926, 95% CI: 1.621–5.281, p < 0.001), body surface area (BSA) (OR = 1.724, 95% CI: 1.011–2.941, p = 0.045), and hypocalcemia (OR = 4.899, 95% CI: 1.518–15.811, p = 0.008) all increased the risk of TIPN. Only cumulative dose (OR = 2.577, 95% CI: 1.161–5.719, p = 0.020) and BSA (OR = 2.040, 95% CI: 1.073–3.877, p = 0.030) were independent risk factors for moderate–severe TIPN.ConclusionCumulative dose, BMI, BSA, and hypocalcemia are all risk factors for overall TIPN, whereas cumulative dose and BSA are risk factors for moderate–severe TIPN. Patients with breast cancer who have high BMI, large BSA, hypocalcemia, and large cumulative dose may be at risk of TIPN, and intervention measures must be actively carried out for them.
One Country, Two Calendars: Lunar January Effect in China's A‐Share Stock Market
Authors: Liang Xiaobo , Liu Qianqiu , Zebedee Allan A. 
Published: January 2023

AbstractIn this paper, we examine the January effect in China's A‐share stock market from January 1995 to December 2019 using both the solar and lunar calendars. Consistent with the existing literature, we find the absence of a traditional January effect in the solar calendar; however, we observe a strong January effect in the lunar calendar. Moreover, the effect is much stronger in small firms. We demonstrate that the tax‐loss selling and window dressing hypotheses cannot explain the turn‐of‐the‐year effect in China. Instead, the turn‐of‐the‐year effect in trading volume and buy orders help to explain the strong lunar January effect. As a falsification test, we examine the B‐share market that is predominantly composed of foreign investors and find no evidence of the lunar January effect. Our results show that Chinese financial markets are more closely aligned with the traditional lunar calendar than the standard solar calendar.
Global Economic Integration and Nativist Politics in Emerging Economies
Authors: Helms Benjamin 
Published: January 2023

AbstractNativist political movements are globally ascendant. In advanced democracies, rising anti‐immigrant politics is in part a backlash against economic globalization. In emerging economies, where nativists primarily target internal migrants, there is little investigation of whether trade liberalization fuels antimigrant sentiment, perhaps because trade benefits workers in these contexts. I argue that global economic integration causes nativist backlash in emerging economies even though it does not dislocate workers. I highlight an alternative mechanism: geographic labor mobility. Workers strategically migrate to access geographically uneven global economic opportunity. This liberalization‐induced mobility interacts with native–migrant cleavages to generate nativist backlash. I explore these dynamics in the Indian textile sector, which experienced a positive shock following global trade liberalization in 2005. Using a difference‐in‐differences analysis, I find that exposed localities experienced increased internal migration and nativism, manifesting in antimigrant rioting and nativist party support. Liberalization can fuel nativism even when its economic impacts are positive.
European Academy of Allergy and Clinical Immunology position paper on endoscopic scoring of nasal polyposis
Authors: Gevaert Philippe , De Craemer Jarno , Bachert Claus , Blauwblomme Manon , Chaker Adam , Cingi Cemal , Hellings Peter W. , Hopkins Claire , Hox Valérie , Fokkens Wytske J. , Klimek Ludger , Lund Valerie , Mösges Ralph , Mullol Joaquim , Pfaar Oliver , Scadding Glenis , Tomazic Peter Valentin , Van Zele Thibaut , Vlaminck Stephan , Wagenmann Martin , Toppila‐Salmi Sanna , Alobid Isam 
Published: January 2023

AbstractNasal endoscopy is not only used for the diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP), but also for monitoring the response to therapy playing an important role in both daily practice and research. In contrast to patient‐reported outcomes, endoscopic nasal polyp scoring by independent blinded readers is an objective measurement, not influenced by the placebo effect. It is safer and cheaper compared with computed tomography imaging and therefore, better suited for regular assessments of the extent of the disease. Since the early 90s, a variety of endoscopic staging methods have been proposed and used in clinical research, making it hard to compare results from different studies. This paper resulted from a task force with experts in the field of CRSwNP, originated by the Ear, Nose and Throat section of the European Academy of Allergy and Clinical Immunology and aims to provide a unified endoscopic NP scoring system that can serve as a reference standard for researchers, but also as a useful tool for practitioners involved in the management of CRSwNP.
Management of adult patients with haematological malignancies in critical care
Authors: Fizza Haider S. , Sloss R. , Jhanji S. , Nicholson E. , Creagh‐Brown B. 
Published: January 2023

SummaryThere are a diverse range of haematological malignancies with varying clinical presentations and prognoses. Patients with haematological malignancy may require admission to critical care at the time of diagnosis or due to treatment related effects and complications. Although the prognosis for such patients requiring critical care has improved, there remain uncertainties in optimal clinical management. Identification of patients who will benefit from critical care admission is challenging and selective involvement of palliative care may help to reduce unnecessary and non‐beneficial treatments. While patients with haematological malignancy can present a challenge to critical care physicians, good outcomes can be achieved. In this narrative review, we provide a brief overview of relevant haematological malignancies for the critical care physician and a summary of recent treatment advances. Subsequently, we focus on critical care management for the patient with haematological malignancy including sepsis; acute respiratory failure; prevention and treatment of tumour lysis syndrome; thrombocytopaenia; and venous thromboembolism. We also discuss immunotherapeutic‐specific related complications and their management, including cytokine release syndrome and immune effector cell associated neurotoxicity syndrome associated with chimeric antigen receptor T‐cell therapy. While the management of haematological malignancies is highly specialised and increasingly centralised, acutely unwell patients often present to their local hospital with complications requiring critical care expertise. The aim of this review is to provide a contemporary overview of disease and management principles for non‐specialist critical care teams.
Blood, dose recommendation reports and phone calls: Experiences of a therapeutic drug monitoring advisory service for vancomycin
Authors: Carland Jane E. , Stacy Alexandra E. , Schaffer Andrea L. , Day Richard O. , Brett Jonathan , Reuter Stephanie E. , Stocker Sophie L. 
Published: January 2023

Dose‐prediction software is recommended to enable area under the curve over 24 h (AUC24)‐guided dosing of the antibiotic vancomycin. However, uncertainty remains about how best to implement software in the clinic. We describe the activity, over 18 months, of a consultative therapeutic drug monitoring Advisory Service (the Service) for vancomycin that used dose‐prediction software alongside clinical expertise, identifying factors that influence attainment of therapeutic targets. Of the 408 vancomycin dose reports provided for 182 courses of therapy, most (57%) recommended a dose change. The majority (82.8%, 193/233) of recommended dose adjustments were accepted by treating teams. A dose report was not published for 125 courses of therapy, with reasons including patient in intensive care unit or service error. An estimated 26.6 h of staff time was allocated to Service activities each month. Publication of a dose report facilitated attainment of therapeutic targets (P = .002). Software integration could improve Service outcomes, avoiding errors and reducing staff workload.
Picamilon, a γ‐aminobutyric acid (GABA) analogue and marketed nootropic, is inactive against 50 biological targets
Authors: Santillo Michael F. , Sprando Robert L. 
Published: January 2023

AbstractPicamilon is an analogue of the neurotransmitter γ‐aminobutyric acid (GABA), which is marketed as a nootropic claiming to enhance cognition. There is a lack of in silico, in vitro and in vivo data on the safety of picamilon. Therefore, to ascertain potential physiological effects of picamilon, it was screened against 50 safety‐related biological targets (receptors, ion channels, enzymes and transporters) by in silico and in vitro methods. Using two in silico tools, picamilon was not predicted to bind to the targets. Similarly, picamilon exhibited weak or no binding to the targets when measured in vitro at 10 μM. Overall, this data shows that picamilon, although structurally similar to other GABA analogues, has a different biological target binding profile. Picamilon's lack of binding to the 50 targets fills important data gaps among GABA analogues, a group of structurally related substances found in drugs and other consumer products.
Heat flow and thermal regime in the Guaymas Basin, Gulf of California: Estimates of conductive and advective heat transport
Authors: Neumann Florian , Negrete‐Aranda Raquel , Harris Robert N. , Contreras Juan , Galerne Christophe Y. , Peña‐Salinas Manet S. , Spelz Ronald M. , Teske Andreas , Lizarralde Daniel , Höfig Tobias W. ,   Expedition 385 Scientists
Published: January 2023

AbstractHeat flow is estimated at eight sites drilled int the Guaymas Basin, Gulf of California, during the International Ocean Discovery Program Expedition 385. The expedition sought to understand the thermal regime of the basin and heat transfer between off‐axis sills intruding the organic‐rich sediments of the Guaymas Basin, and the basin floor. The distinct sedimentation rates, active tectonics, and magmatism make the basin interesting for scientific discoveries. Results show that sedimentation corrected heat flow values range 119–221 mW/m2 in the basin and 257–1003 mW/m2 at the site of a young sill intrusion, denominated Ringvent. Thermal analysis shows that heat in the Guaymas Basin is being dissipated by conduction for plate ages >0.2 Ma, whereas younger plate ages are in a state of transient cooling by both conduction and advection. Drilling sites show that Ringvent is an active sill being cooled down slowly by circulating fluids with discharge velocities of 10–200 mm/yr. Possible recharge sites are located ca. 1 km away from the sill's border. Modelling of the heat output at Ringvent indicates a sill thickness of ca. 240 m. A simple order‐of‐magnitude model predicts that relatively small amounts of magma are needed to account for the elevated heat flow in non‐volcanic, sediment‐filled rifts like the central and northern Gulf of California in which heating of the upper crust is achieved via advection by sill emplacement and hydrothermal circulation. Multiple timescales of cooling control the crustal, chemical and biological evolution of the Guaymas Basin. Here, we recognize at least four timescales: the time interval between intrusions (ca. 103 yr), the thermal relaxation time of sills (ca. 104 yr), the characteristic cooling time of the sediments (ca. 105 yr), and the cooling of the entire crust at geologic timescales.
A part of, yet apart from the team: Substantive membership and belonging of trans and nonbinary athletes
Authors: Greey Ali Durham 
Published: January 2023

AbstractIncreasingly, bills and policies prohibit the participation of trans women in competitive sport. The current sociopolitical moment begs the following question: how do interpersonal interactional moments function alongside formal policies and rules to shape trans athletes’ experiences of belonging in sport? Although formal institutional rules govern trans athletes’ ability to compete in sport, informal social sanctioning also denies these athletes equitable, or even de facto, membership in sport. I draw upon two case studies to explore trans athletes’ experiences of membership in elite “women's” sport. I apply Evelyn Nakano Glenn's work on citizenship to consider how trans athletes’ experiences of belonging are influenced by both formal rules imposed by organizations as well as informal social interactions with members of their sporting communities. Inclusion is not synonymous with membership. Trans athletes render visible the ways in which this system functions to contain the diversity of humanity's gender expression.
Monolithic Friction and Contact Handling for Rigid Bodies and Fluids Using SPH
Authors: Probst T. , Teschner M. 
Published: January 2023

AbstractWe propose a novel monolithic pure SPH formulation to simulate fluids strongly coupled with rigid bodies. This includes fluid incompressibility, fluid–rigid interface handling and rigid–rigid contact handling with a viable implicit particle‐based dry friction formulation. The resulting global system is solved using a new accelerated solver implementation that outperforms existing fluid and coupled rigid–fluid simulation approaches. We compare results of our simulation method to analytical solutions, show performance evaluations of our solver and present a variety of new and challenging simulation scenarios.
First‐in‐human study with SAR445088: A novel selective classical complement pathway inhibitor
Authors: Chow Timothy , Shamszad Pirouz , Vinnard Christopher , Yoon Esther , Belinski Julia , Karpenko Irene , Perrin Laurent , Auwarter Kristen , Storek Michael , Surks Howard , Wong Nancy , Cohen Yehuda Z. 
Published: January 2023

AbstractSAR445088 is an anti‐C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system and has the potential to provide clinical benefit in the treatment of complement‐mediated diseases. A phase I, first‐in‐human, double‐blind, randomized, placebo‐controlled, dose‐escalation trial of single and multiple doses of SAR445088 was conducted in 93 healthy participants to evaluate the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profiles. Single (intravenous [i.v.] and subcutaneous [s.c.]) ascending doses (SAD) and multiple (s.c.) ascending doses (MAD) of SAR445088 were well‐tolerated. The PK of SAR445088 was characterized by slow absorption after the s.c. dose and a long half‐life (mean terminal half‐life [t1/2] 8–15 weeks). Two PD assays were used to measure inhibition of the classical complement pathway (CP): Wieslab CP and complement mediated hemolytic capacity (CH50). The estimated half‐maximal inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) for the Wieslab CP assay were 96.4 and 458 μg/ml, respectively, and 16.6 and 57.0 μg/ml, respectively, for the CH50 assay. In summary, SAR445088 was well‐tolerated and had favorable PK and PD profiles after SAD (i.v. or s.c.) and MAD (s.c.) in humans. These findings warrant further clinical investigations in patients with classical complement‐mediated disorders.
Cutaneous Sporothrix globosa infection mimicking cryptococcosis in a patient with history of kidney transplant
Authors: Lin Erica M. , Singer Hannah , Telang Gladys H. , Chau Thinh , Farmakiotis Dimitrios , Robinson‐Bostom Leslie 
Published: January 2023

AbstractSporotrichosis is a subacute‐to‐chronic infection caused by Sporothrix species, a dimorphic fungus. Virulence varies by Sporothrix species and presentation can be region dependent. The patient had a history of immunosuppression as a result of a kidney transplant, and presented with a high disease burden on histopathological examination, but responded well to itraconazole. The case suggests considering Sporothrix speciation in immunocompromised patients to best determine treatment modality and duration.