bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Listeria monocytogenes in milk in Africa: a generalized logistic mixed-effects and meta-regression modelling
Authors: Oluwafemi Yinka D. , Igere Bright E. , Ekundayo Temitope C. , Ijabadeniyi Oluwatosin A. 
Published: August 2023

AbstractListeria outbreaks and food recalls is on the raise globally. Milk particularly is highly susceptible to Listeria as its production and storage adequately support Listeria growth. The extent of milk contamination with Listeria monocytogenes (Lm) and preventative actions to halt milk associated outbreaks in Africa are unknown. Hence, this study aimed at assessing the national and subregional prevalence of Lm in milk in Africa and identify impacting factors via generalized logistic mixed-effects (GLMEs) and meta-regression modelling. Lm-milk-specific data acquired from primary studies according to standard protocol were fitted using a GLMEs. The GLMEs was subjected to leave-one-study-out-cross-validation (LOSOCV). Factors impacting Lm prevalence in milk were assayed via a 1000-permutation-assisted meta-regression-modelling. The pooled prevalence of Lm in milk in Africa was 4.35% [2.73–6.86] with a prediction interval (PI) of 0.14–59.86% and LOSOCV value of 2.43% [1.62–3.62; PI: 0.32–16.11%]. Western Africa had the highest prevalence [20.13%, 4.13–59.59], then Southern Africa [5.85%, 0.12–75.72], Northern Africa [4.67%, 2.82–7.64], Eastern Africa [1.91%, 0.64–5.55], and there was no record from Central Africa. In term of country, Lm prevalence in milk significantly (p < 0.01) varied from 0.00 to 90.00%. Whereas the Lm prevalence was negligibly different (p = 0.77) by milk type, raw-milk had the highest prevalence [5.26%], followed by fermented-milk [4.76%], boiled-milk [2.90%], pasteurized-milk [1.64%], and powdered-milk [1.58%]. DNA extraction approach did not significantly (p = 0.07) affect Lm prevalence (Boiling [7.82%] versus Kit [7.24%]) as well as Lm detection method (p = 0.10; (ACP [3.64%] vs. CP [8.92%] vs. CS [2.27%] vs. CSP [6.82%]). Though a bivariate/multivariate combination of all tested variables in meta-regression explained 19.68–68.75% (R2) variance in Lm prevalence in milk, N, nation, and subregion singly/robustly accounted for 17.61% (F1;65 = 7.5994; p = 0.005), 63.89% (F14;52 = 4.2028; p = 0.001), and 16.54% (F3;63 = 3.4743; p = 0.026), respectively. In conclusion, it is recommended that adequate sample size should be prioritized in monitoring Lm in milk to prevent spuriously high or low prevalence to ensure robust, plausible, and credible estimate. Also, national efforts/interests and commitments to Lm monitoring should be awaken.
1-year survival rate of SARS-CoV-2 infected patients with acute respiratory distress syndrome based on ventilator types: a multi-center study
Authors: Mahmoodpor Ata , Gohari-Moghadam Kievan , Rahimi-Bashar Farshid , Khosh-Fetrat Masoum , Vahedian-Azimi Amir 
Published: August 2023

AbstractThe aim of this study was to evaluate the association between types of ventilator and the one-year survival rate of patients with acute respiratory distress syndrome (ARDS) due to SARS‑CoV-2 infection. This multi-center, retrospective observational study was conducted on 1078 adult patients admitted to five university-affiliated hospitals in Iran who underwent mechanical ventilator (MV) due to ARDS. Of the 1078 patients, 781 (72.4%) were managed with ICU ventilators and 297 (27.6%) with transport ventilators. Overall mortality was significantly higher in patients supported with transport ventilator compared to patients supported with ICU ventilator (16.5% vs. 9.3% P = 0.001). Regression analysis revealed that the expected hazard overall increased with age (HR: 1.525, 95% CI 1.112–1.938, P = 0.001), opacity score (HR: 1.448, 95% CI 1.122–2.074, P = 0.001) and transport ventilator versus ICU ventilator (HR: 1.511, 95% CI 1.143–2.187, P = 0.029). The Kaplan–Meier curves of survival analysis showed that patients supported with ICU ventilator had a significantly higher 1-year survival rate (P = 0.001). In MV patients with ARDS due to COVID-19, management with non-ICU sophisticated ventilators was associated with a higher mortality rate compared to standard ICU ventilators. However, more studies are needed to determine the exact effect of ventilator types on the outcome of critically ill patients.
Silver-catalyzed vinylcarbene insertion into Si–H bonds with vinyl N-triftosylhydrazones leading to allylsilanes
Authors: Wu Yong , Song Qingmin , Xia Ying , Ning Yongquan , Sivaguru Paramasivam , Bi Xihe 
Published: August 2023

An efficient silver-catalyzed insertion into the Si–H bonds of silane with vinyl N-triftosylhydrazones has been developed, which exhibits excellent broad substrate scope and good functional group compatibility to deliver allylsilanes in high yields.
Untere und mittlere gastrointestinale Blutung
Authors: Albert Jörg G. , Grün Kira , Sarrazin Christoph 
Published: August 2023

ZusammenfassungBlutungen aus dem Gastrointestinaltrakt werden in obere, mittlere und untere gastrointestinale Blutung unterschieden. Die Diagnostik kann eine Herausforderung sein und ist eine Domäne der
Koloskopie, der Kapselendoskopie oder der flexiblen Enteroskopieverfahren. Als endoskopische Therapieoptionen stehen die Injektionstherapie, Metallclips, eine thermische Behandlung sowie die
Gummibandligatur zur Verfügung, eine chirurgische Resektion ist nur selten erforderlich.
Normal Serum Levels of Otolin-1 in Patients with Meniere Disease in Remission
Authors: Singh Anup , Yadav Harsha , Verma Hitesh , Sikka Kapil , Abraham Ransi Ann , Irugu David Victor Kumar 
Published: August 2023

Abstract
Introduction Degenerative changes in the otolithic organs have been theorized to be caused by the mechanical obstruction to endolymphatic flow, possibly resulting in endolymphatic hydrops (ELH). Otolin-1 is an otoconial matrix protein that crosses the blood labyrinth barrier and has been found in the serum of healthy and diseased patients.
Objective To measure the serum levels of Otolin-1 in Meniere disease (MD) patients and compared them with the healthy individuals.
Methods This pilot, cross-sectional study was performed at our tertiary care referral center to compare the serum Otolin-1 levels of healthy individuals with those of MD patients. The blood samples were obtained during patients' visit to the vertigo clinic following remission of an acute episode. The data was analyzed using the Stata/SE version 12.0 (StataCorp. College Station, TX, USA). Comparison between the serum Otolin-1 levels in the two groups was performed using the unpaired t-test. A p-value of 0.05 was considered to be statistically significant.
Results The participants were divided into two groups, with 31 MD patients, and 30 age and gender-matched members of the control group. The serum levels of Otolin-1 in MD patients (247.6, ± 44.2 pg/ml) were not found to be significantly different from those of the control group (236.2, ± 43.5 pg/ml) (p = 0.31).
Conclusion The current study reveals that the serum levels of Otolin-1 are not significantly different between the patients with MD in the interictal phase and the control group's healthy ones.
Virtual Teaching and Training Models in Pediatric Oncology: A Retrospective Study from an LMIC
Authors: Farooq Wasfa , Baig Natasha , Khan Bashir Ahmed , Raza Muhammad Rafie 
Published: August 2023

Abstract
Introduction A multidisciplinary approach is essential for success in pediatric oncology treatment. Updated protocols, quality nursing care, psychosocial support, safe and standardized preparation of chemotherapy, infection control, and effective data management are key shareholders for the effective management of childhood cancer. The Department of Pediatric Oncology at Indus Hospital and Health Network (IHHN) initiated consistent teaching and trainings with the help of the My Child Matters Grant from Sanofi Espoir Foundation. These courses were conducted in person starting in 2019 and had to be postponed and restructured due to coronavirus (COVID-19) pandemic in early 2020.
Objectives The aim of this study was to determine the impact of virtual teaching models for healthcare workers employed in pediatric hematology/oncology departments in low-resource settings.
Materials and Methods After in-person courses in 2019, courses for all six disciplines (physicians, nursing, infection control, pharmacy, psychosocial care, and cancer registry) were conducted virtually starting December 2020, open to all and free of cost. A total of 878 registrations were obtained and 267 certifications given. Lectures with Q&A sessions were conducted via zoom and recordings shared through email. Each course was conducted by the relevant department at IHHN with pre- and postassessment conducted through Google Forms. Session feedback was taken through zoom polls and a comprehensive course feedback conducted after completion; e-certificates were awarded to successful participants according to a predetermined criterion.
Results A total of 434 physicians' registrations were done from around Pakistan and countries like Saudi Arabia, Malaysia, Jordan, and Canada for the online physicians' course, of which 110 received certifications after completing post-test and attendance criteria of 55%. Pharmacy, infection control, psychosocial care, and cancer registry courses saw participation and certification of 51, 41, 24, and 14 participants, respectively. Online sessions received positive feedback in terms of instructors, course content, convenience, and access from over 90% participants.
Conclusion Due to the ease in coordinating hectic schedules and cost-effectiveness of online lectures, this virtual teaching model will persist despite the trajectory of the COVID-19 pandemic. Similar ventures aimed at pediatric oncology teaching and training are needed in a widespread manner to improve outcomes of childhood cancer.
Breaking the Bad News in Cancer: An In-Depth Analysis of Varying Shades of Ethical Issues
Authors: Baliga Manjeshwar Shrinath , Prasad Krishna , Rao Suresh , Hegde Sanath Kumar , Sacheendran Dhanya , Krishna Abhishek , Simon Paul , George Thomas , Palatty Princy Louis 
Published: August 2023

AbstractOncology has a range of ethical issues that are difficult to address and breaking the bad news is probably the most important and common across the world. Conventionally, breaking the bad news has been exclusively used in the situation where definitive diagnosis of cancer is to be conveyed to the patient. On a practical note, for the treating doctor, breaking the bad news is not restricted only to the confirmation of cancer and its prognosis at the initial diagnosis but also includes conveying futility of curative treatment, changing from curative to palliative treatment, recurrence/metastasis posttreatment, end of life care, and finally informing death of the patient to the family members. In addition to this, informing pregnant women that she has been diagnosed with cancer, about surgery-induced body disfigurement, loss of fertility due to chemotherapy/ radiotherapy, and of treatment-induced irreversible health complications are also challenging for the treating oncologist. On the basis of an in-depth analysis, the current review presents the various situations, complexities, and the related ethical issues in breaking the bad news in various situations from the perspective of an oncologist in detail in Indian context.
Excitonic and deep-level emission from N- and Al-polar homoepitaxial AlN grown by molecular beam epitaxy
Authors: van Deurzen L. , Singhal J. , Encomendero J. , Pieczulewski N. , Chang C. S. , Cho Y. , Muller D. A. , Xing H. G. , Jena D. , Brandt O. , Lähnemann J. 
Published: August 2023

Using low-temperature cathodoluminescence spectroscopy, we study the properties of N- and Al-polar AlN layers grown by molecular beam epitaxy on bulk AlN{0001}. Compared with the bulk AlN substrate, layers of both polarities feature a suppression of deep-level luminescence, a total absence of the prevalent donor with an exciton binding energy of 28 meV, and a much increased intensity of the emission from free excitons. The dominant donor in these layers is characterized by an associated exciton binding energy of 13 meV. The observation of excited exciton states up to the exciton continuum allows us to directly extract the Γ5 free exciton binding energy of 57 meV.
Student-led pop-up health check clinics: innovative health prevention strategy for a low socioeconomic community
Authors: Coombs Nicole M. , Sewell Lauren , Jackson Megan R. , Borgelt Kaye , Lee Jessica , Porter Joanne E. 
Published: August 2023

Background To improve preventative health screening in regional Victoria, Australia, a collaborative student-led health prevention strategy was initiated. The aim of this study is to evaluate the impact of four health check clinics using a free ‘pop-up’ format within community settings. Methods A mixed methods, explanatory sequential design was used to explore community health data and participant experiences in utilising the free health check clinics. The clinics were delivered over 6 months and located in three different communities within the regional government area. Descriptive statistics were used to analyse participant health data and a thematic analysis was utilised to determine themes from participant feedback and health outcomes. Results The clinics were attended by 188 community members, largely impacted by government lockdowns during the coronavirus disease 2019 (COVID-19) pandemic. Health check results indicate the population is overweight and at high risk of diabetes. Participants enjoyed the free and convenient nature of the health check program and the location of the venues. Feedback from participants indicate the health education provided was useful and advocated for changes in current behaviours. Many embraced the new information and community connections and made changes to improve their future health. Others claimed to enjoy the clinic experience but reported no action from the recommendations. Conclusions Evaluation of the health check clinics indicate they had a minor, yet positive impact on the local community in increasing engagement with preventative screening strategies. COVID-19 restrictions impacted participant numbers and thus more research is needed in a time where community movement is not limited.
A flexible and ultra-highly sensitive tactile sensor based on Mg-doped ZnO nanorods for human vital signs and activity monitoring
Authors: Li Ming , Yao Ruohe , Liu Yurong 
Published: August 2023

Abstract
Development of high-performance nano-ZnO based piezoelectric tactile sensors with outstanding sensitivity, good linearity, flexibility, durability and biocompatibility has a great significance for smart robotics, human healthcare devices, smart sensors and electronic skins. A flexible piezoelectric pressure sensor with a sandwich structure was fabricated by using PI/Cu film as top and bottom electrodes, Mg-doped ZnO nanorods (MZO NRs) as sensing layer and polydimethylsiloxane polymer as charge coupling layer. The MZO NRs were synthesized by a one-step hydrothermal method and their structure, morphology and defect states were characterized by using scanning electron microscopy, atomic force microscope and x-ray photoelectron spectroscopy. The piezoelectric properties of the flexible tactile sensors based on MZO NRs hydrothermally synthesized from different Mg2+/Zn2+ molar ratios were investigated comparatively by evaluating their force response actions. The results indicate that the sensors exhibit a linear response in the range of 0–1 N. The device based on MZO NRs can achieve an ultra-high sensitivity of 3.1 V N−1 (308.5 mV kpa−1) due to higher piezoelectric coefficient of MZO NRs, which is about five times higher than that of the undoped ZnO NRs sensor. Moreover, the sensor shows excellent stability and durability by loading 2500 cycles of pressing. It is demonstrated that the sensor can used to accurately monitor human motion status and vital signs in real time, such as facial motion, joint movement, wrist pulse, cervical artery, and heartbeat.
Microscopic origin of local electric polarization in NiPS3
Authors: Kim Hyeon Jung , Kim Ki-Seok 
Published: August 2023

Abstract
Recently, Zhang–Rice triplet to singlet excitations have been measured experimentally and verified numerically in a van der Waals antiferromagnet NiPS3, which reveals a collective local change of an electronic structure. In particular, such numerical simulations predicted that these electronic excitations occur simultaneously with local electric polarizations. In this study, we uncover the microscopic origin of this local electric polarization in the Zhang–Rice triplet to singlet excitation. Our lattice-model calculation predicts that the electric polarization can be controlled by applied magnetic fields, where the atomic spin–orbit coupling plays an important role. We speculate emergence of real space Berry curvature to describe the electric polarization in this strongly correlated system.
Angiotensin II-Induced Memory γδ T Cells Sensitize Mice to a Mild Hypertensive Stimulus
Authors: Comeau Kevin , Shokoples Brandon , Caillon Antoine , Paradis Pierre , Schiffrin Ernesto L 
Published: August 2023

Abstract

BACKGROUND
Memory T cells develop during an initial hypertensive episode, sensitizing mice to develop hypertension from further mild hypertensive challenges. We hypothesized that memory γδ T cells develop after a hypertensive challenge and sensitize mice to develop hypertension in response to a subsequent mild hypertensive challenge.

METHODS
The first aim was to profile memory γδ T cells after a 14-day pressor dose angiotensin II (AngII) infusion (490 ng/kg/min, subcutaneously) in male mice. The second aim was to deplete γδ T cells during a second 14-day subpressor dose AngII challenge (140 ng/kg/min, subcutaneously) in mice pre-exposed to an initial pressor dose AngII challenge. The third aim was to transfer 2.5 × 105 live pre-activated or not γδ T cells from mice that had received a 14-day pressor dose AngII infusion or sham treatment, to naive recipient mice stimulated with a subpressor dose AngII infusion.

RESULTS
Effector memory γδ T cells increased 5.2-fold in mesenteric vessels and perivascular adipose tissue, and 1.8-fold in mesenteric lymph nodes in pressor dose AngII-infused mice compared with sham-treated mice. Mice depleted of γδ T cells had 14 mm Hg lower systolic blood pressure (SBP) elevation than control mice from day 7 to 14 of subpressor dose AngII infusion. Adoptive transfer of γδ T cells from hypertensive mice induced an 18 mm Hg higher SBP elevation compared with a subpressor dose AngII infusion vs. γδ T cells transferred from sham-treated mice.

CONCLUSIONS
Memory γδ T cells develop in response to hypertensive stimuli, and contribute to the pathogenesis of hypertension.
DeepCMI: a graph-based model for accurate prediction of circRNA–miRNA interactions with multiple information
Authors: Li Yue-Chao , You Zhu-Hong , Yu Chang-Qing , Wang Lei , Hu Lun , Hu Peng-Wei , Qiao Yan , Wang Xin-Fei , Huang Yu-An 
Published: August 2023

Abstract
Recently, the role of competing endogenous RNAs in regulating gene expression through the interaction of microRNAs has been closely associated with the expression of circular RNAs (circRNAs) in various biological processes such as reproduction and apoptosis. While the number of confirmed circRNA–miRNA interactions (CMIs) continues to increase, the conventional in vitro approaches for discovery are expensive, labor intensive, and time consuming. Therefore, there is an urgent need for effective prediction of potential CMIs through appropriate data modeling and prediction based on known information. In this study, we proposed a novel model, called DeepCMI, that utilizes multi-source information on circRNA/miRNA to predict potential CMIs. Comprehensive evaluations on the CMI-9905 and CMI-9589 datasets demonstrated that DeepCMI successfully infers potential CMIs. Specifically, DeepCMI achieved AUC values of 90.54% and 94.8% on the CMI-9905 and CMI-9589 datasets, respectively. These results suggest that DeepCMI is an effective model for predicting potential CMIs and has the potential to significantly reduce the need for downstream in vitro studies. To facilitate the use of our trained model and data, we have constructed a computational platform, which is available at http://120.77.11.78/DeepCMI/. The source code and datasets used in this work are available at https://github.com/LiYuechao1998/DeepCMI.
Brain functional characterization of response-code conflict in dual-tasking and its modulation by age
Authors: Paas Oliveros Lya K , Cieslik Edna C , Pieczykolan Aleks , Pläschke Rachel N , Eickhoff Simon B , Langner Robert 
Published: August 2023

AbstractCrosstalk between conflicting response codes contributes to interference in dual-tasking, an effect exacerbated in advanced age. Here, we investigated (i) brain activity correlates of such response-code conflicts, (ii) activity modulations by individual dual-task performance and related cognitive abilities, (iii) task-modulated connectivity within the task network, and (iv) age-related differences in all these aspects. Young and older adults underwent fMRI while responding to the pitch of tones through spatially mapped speeded button presses with one or two hands concurrently. Using opposing stimulus–response mappings between hands, we induced conflict between simultaneously activated response codes. These response-code conflicts elicited activation in key regions of the multiple-demand network. While thalamic and parietal areas of the conflict-related network were modulated by attentional, working-memory and task-switching abilities, efficient conflict resolution in dual-tasking mainly relied on increasing supplementary motor activity. Older adults showed non-compensatory hyperactivity in left superior frontal gyrus, and higher right premotor activity was modulated by working-memory capacity. Finally, connectivity between premotor or parietal seed regions and the conflict-sensitive network was neither conflict-specific nor age-sensitive. Overall, resolving dual-task response-code conflict recruited substantial parts of the multiple-demand network, whose activity and coupling, however, were only little affected by individual differences in task performance or age.
Temporal trends in the utilization of advanced therapies among patients with acute pulmonary embolism: insights from a national database
Authors: Abumoawad Abdelrhman , Shatla Islam , Behrooz Leili , Eberhardt Robert T , Hamburg Naomi , Sedhom Rami , Elgendy Islam Y , Kumbhani Dharam J , Cameron Scott J , Elbadawi Ayman 
Published: August 2023

Abstract
There is a paucity of data regarding the contemporary temporal trends in the adoption of advanced pulmonary embolism (PE) therapies in the United States as well as the parallel trends in outcomes of patients with acute PE. Therefore, we queried the Nationwide Readmissions Database (years 2016–2020) to report the temporal trends in utilization of advanced PE therapies. Our final analysis included 920 770 hospitalizations with acute PE. We demonstrated an increase in the proportion of patients diagnosed with high-risk PE during the study years. Overall, there was an increase in the use of advanced PE therapies, which was mainly due to the increase in the utilization of systemic thrombolytics, and catheter-directed therapies. Also, extracorporeal membrane oxygenation cannulation showed an incremental increase over the study years. The use of inferior vena cava filter has declined, while the use of surgical embolectomy did not change during the study years. The use of advanced therapies has increased among urban teaching, but not among urban non-teaching hospitals. During the study years, there was no change in unadjusted or adjusted in-hospital mortality rates among patients with acute PE, while the 90-day unplanned readmission rate has declined.