bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGATURAN USIA PENSIUN PEKERJA DI PT SURYA TOTO INDONESIA Tbk DIHUBUNGKAN DENGAN PERATURAN PEMERINTAH NOMOR 45 TAHUN 2015 TENTANG PENYELENGGARAAN PROGRAM JAMINAN PENSIUN
Authors: Prayitno Sugeng , Iskandar Imam 
Published: May 2023

Secara umum, pensiun adalah suatu masa dimana pekerja/pegawai sudah tidak bekerja lagi sehubungan dengan pemutusan hubungan kerja pada instansi/perusahaan karena pekerja/pegawai tersebut telah mencapai batas usia tertentu. Di PT Surya Toto Indonesia Tbk, pengaturan usia pensiun pekerja diatur berdasarkan Perjanjian Kerja Bersama. Pengaturan usia pensiun tersebut berbeda dengan ketentuan usia pensiun dari Pemerintah untuk pekerja yang menjadi peserta program jaminan pensiun Badan Penyelenggara Jaminan Sosial (BPJS) Ketenagakerjaan, yang diatur dalam Peraturan Pemerintah Nomor 45 Tahun 2015 Tentang Penyelenggaraan Program Jaminan Pensiun
Penelitian ini menggunakan bentuk penelitian kualitatif yang bersifat yuridis normatif dengan pendekatan peraturan perundang-undangan. Jenis bahan hukum dalam penelitian ini terdiri dari bahan hukum primer dan bahan hukum sekunder. Bahan-bahan hukum tersebut kemudian dianalisa dengan menggunakan teknik penelitian terhadap taraf sinkronisasi secara vertikal.
Terdapat perbedaan dan dampak dari pengaturan dan pelaksanaan usia pensiun pekerja di PT Surya Toto Indonesia Tbk dihubungkan dengan Peraturan Pemerintah Nomor 45 Tahun 2015 Tentang Penyelenggaraan Program Jaminan Pensiun. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa: (1) Terdapat ketidaksinkronan peraturan perundang-undangan akibat dari perbedaan pengaturan dan pelaksanaan usia pensiun pekerja di PT Surya Toto Indonesia Tbk berdasarkan Perjanjian Kerja Bersama dihubungkan dengan Peraturan Pemerintah Nomor 45 Tahun 2015 Tentang Penyelenggaraan Program Jaminan Pensiun, menunjukkan bahwa tidak terpenuhinya beberapa kaidah hukum tentang logika ilmu hukum, yaitu: kaidah nonkontradiksi (principle of integrity), kaidah derivatif (derivative principle), kaidah sistem (systemic principle), kaidah reduksi (principle of reductionism). (2) Adanya “masa tunggu” bagi pekerja di PT Surya Toto Indonesia Tbk yang telah pensiun, karena tertundanya pembayaran manfaat jaminan pensiun sebagai peserta program jaminan pensiun Badan Penyelenggara Jaminan Sosial (BPJS) Ketenagakerjaan akibat dari pengaturan usia pensiun dalam Peraturan Pemerintah Nomor 45 Tahun 2015 yang berjenjang, sehingga tidak dapat langsung memperoleh manfaat jaminan pensiun, yang seharusnya dalam konsep jaminan pensiun idealnya adalah bahwa peserta akan mendapatkan hak atas manfaat jaminan pensiun pada saat memasuki usia pensiun.
Clinical significance of FBXO43 in hepatocellular carcinoma and its impact on tumor cell proliferation, migration and invasion
Authors: Ma Rulan , Liu Wenbo , Sun Tuanhe , Dang Chengxue , Li Kang 
Published: May 2023

Background
The effects of FBXO43 on hepatocellular carcinoma (HCC) and its clinical significance have not yet been determined. This study aims to determine the clinical significance of FBXO43 in HCC and its impact on the biological functions of HCC cells.

Methods
Data from TCGA database were downloaded to investigate the expression of FBXO43 in HCC and its correlation with prognosis and immune infiltration. Immunohistochemical staining images of FBXO43 in HCC were acquired from the HPA website. HCC cells (BEL-7404 and SMMC-7721) were transfected with the lentivirus targeting FBXO43 to decrease FBXO43 expression in HCC cells. Western blotting assay was conducted to evaluate the expression level of FBXO43 protein. MTT assay was used to detect the proliferation of HCC cells. The migration and invasion of HCC cells were investigated by performing scratch wound-healing and Transwell invasion assays, respectively.

Results
In comparison to normal tissues, FBXO43 is overexpressed in HCC tissue, and high FBXO43 expression is linked to late T stage, TNM stage and tumor grade. Elevated FBXO43 expression is a risk factor for HCC. In patients with high FBXO43 expression, the overall survival, disease-specific survival, progression-free survival and disease-free survival are poorer. The proliferation, migration and invasion of HCC cells are significantly attenuated in FBXO43 knockdown cells. Also, TCGA data analysis reveals that FBXO43 exhibits a positive correlation with immunosuppression of HCC.

Conclusion
FBXO43 is overexpressed in HCC, and is linked to late tumor stage, worse prognosis and tumor immunosuppression. FBXO43 knockdown restrains the proliferation, migration and invasion of HCC.
Optimising sampling of fish assemblages on intertidal reefs using remote underwater video
Authors: Erickson Katherine R. , Bugnot Ana B. , Figueira Will F. 
Published: May 2023

Background
Assessing fish assemblages in subtidal and intertidal habitats is challenging due to the structural complexity of many of these systems. Trapping and collecting are regarded as optimal ways to sample these assemblages, but this method is costly and destructive, so researchers also use video techniques. Underwater visual census and baited remote underwater video stations are commonly used to characterise fish communities in these systems. More passive techniques such as remote underwater video (RUV) may be more appropriate for behavioural studies, or for comparing proximal habitats where the broad attraction caused by bait plumes could be an issue. However, data processing for RUVs can be time consuming and create processing bottlenecks.

Methods
Here, we identified the optimal subsampling method to assess fish assemblages on intertidal oyster reefs using RUV footage and bootstrapping techniques. We quantified how video subsampling effort and method (systematic vs random) affect the accuracy and precision of three different fish assemblage metrics; species richness and two proxies for the total abundance of fish, MaxNT and MeanCountT, which have not been evaluated previously for complex intertidal habitats.

Results
Results suggest that MaxNT and species richness should be recorded in real time, whereas optimal sampling for MeanCountT is every 60 s. Systematic sampling proved to be more accurate and precise than random sampling. This study provides valuable methodology recommendations which are relevant for the use of RUV to assess fish assemblages in a variety of shallow intertidal habitats.
The Association of Maternal Glycemic Control with Hypertrophic Cardiomyopathy in Infants of Diabetic Mothers
Authors: Kapoor Sanjana , Gupta Ritu 
Published: May 2023

Background: Infants of Diabetic Mothers (IDMs) are at known risk for the development of hypertrophic cardiomyopathy (HCM). Echocardiography is essential for the diagnosis of HCM, to assess the left ventricular function, and the degree of left ventricle obstruction, and to rule out structural cardiac malformations.
Objective: To study the association of maternal third-trimester glycemic level with HCM in IDMs.
Study Design: Observational cross-sectional study.
Participants: 108 diabetic mothers and IDMs.
Intervention: Third-trimester Glycosylated hemoglobin (HbA1c) levels were measured and Echocardiography was done for IDMs in their first week of life. Data were analyzed for correlations between various parameters.
Outcomes: HCM was diagnosed when the absolute value of Inter Ventricular Septum (IVS) was ≥ 2SD from the mean (5mm) and Asymmetrical Septal Hypertrophy (ASH) was diagnosed when the IVS: LVPW ratio was ≥ 1.3.
Results: 85% of the study population had gestational diabetes, and 55.6% of them were on diet control only. The mean HbA1c was 6.69%. The mean birth weight was 3.1 kg. The most common complication observed was hypoglycemia (19.4%). Asymptomatic HCM was seen in 52% and ASH in 25.9% of the study population. HCM was found to be significantly associated with maternal HbA1c levels, birth weight and hypoglycemia.
Conclusion: HCM is a frequent finding in IDMs when routinely screened by echocardiography. A significant positive association of HCM with maternal glycemic control was seen in our study and hence strict glycemic control during pregnancy is of paramount significance.
Age Dependency of Cardiovascular Outcomes With the Amyloidogenic pV142I Transthyretin Variant Among Black Individuals in the US
Authors: Selvaraj Senthil , Claggett Brian L. , Quarta C. Cristina , Yu Bing , Inciardi Riccardo M. , Buxbaum Joel N. , Mosley Thomas H. , Shah Amil M. , Dorbala Sharmila , Falk Rodney H. , Solomon Scott D. 
Published: May 2023

ImportanceHereditary transthyretin cardiac amyloidosis is an increasingly recognized cause of heart failure (HF) with distinct treatment. The amyloidogenic pV142I (V122I) variant is present in 3% to 4% of Black individuals in the US and increases the risk for atrial fibrillation (AF), HF, and mortality. Since hereditary transthyretin cardiac amyloidosis demonstrates age-dependent anatomic penetrance, evaluation later in life may identify survivors at particularly high risk.ObjectiveTo estimate age-dependent risks for cardiovascular events with the variant.Design, Settings, and ParticipantsThis cohort study analyzed Black participants from the Atherosclerosis Risk in Communities (ARIC) study attending visit 1 (1987-1989) (followed up until 2019; median follow-up, 27.6 years). Data analyses were completed from June 2022 to April 2023.ExposurepV142I carrier status.Main outcomesThe association between the variant and AF, HF hospitalization, mortality, and a composite of HF hospitalization or mortality was modeled by generating 10-year absolute risk differences for each year between ages 53 (the median age at visit 1) and 80 years, adjusting for the first 5 principal components of ancestry and sex. As an example, 5- and 10-year risk differences were specifically estimated for the composite outcome among participants surviving to age 80 years.ResultsAmong 3856 Black participants (including 124 carriers) at visit 1, 2403 (62%) were women, 2140 (56%) had hypertension, and 740 (20%) had diabetes, with no differences between groups. The 10-year absolute risk difference between ages 53 and 80 years increased over time for each outcome. Statistical significance for increased 10-year risk difference emerged near ages 65 years for AF, 70 years for HF hospitalization, and 75 years for mortality. Among participants surviving to age 80 years, carriers had a 20% (95% CI, 2%-37%) and 24% (95% CI, 1%-47%) absolute increased risk for HF hospitalization or death at 5 and 10 years, respectively. Thus, at age 80 years, only 4 carriers would need to be identified to attribute 1 HF hospitalization or death over the following decade to the variant.Conclusions and RelevanceIn this study, age-specific risks were provided for relevant outcomes with the pV142I variant. Despite a relatively benign course during earlier years, Black individuals who carry the pV142I variant surviving into later life may be particularly vulnerable. These data may inform timing for screening, risk counseling to patients, and potential strategies for early targeted therapy.
Association of Prehospital Transfusion With Mortality in Pediatric Trauma
Authors: Morgan Katrina M. , Abou-Khalil Elissa , Strotmeyer Stephen , Richardson Ward M. , Gaines Barbara A. , Leeper Christine M. 
Published: May 2023

ImportanceOptimal hemostatic resuscitation in pediatric trauma is not well defined.ObjectiveTo assess the association of prehospital blood transfusion (PHT) with outcomes in injured children.Design, Setting, and ParticipantsThis retrospective cohort study of the Pennsylvania Trauma Systems Foundation database included children aged 0 to 17 years old who received a PHT or emergency department blood transfusion (EDT) from January 2009 and December 2019. Interfacility transfers and isolated burn mechanism were excluded. Analysis took place between November 2022 and January 2023.ExposureReceipt of a blood product transfusion in the prehospital setting compared with the emergency department.Main Outcomes and MeasuresThe primary outcome was 24-hour mortality. A 3:1 propensity score match was developed balancing for age, injury mechanism, shock index, and prehospital Glasgow Comma Scale score. A mixed-effects logistic regression was performed in the matched cohort further accounting for patient sex, Injury Severity Score, insurance status, and potential center-level heterogeneity. Secondary outcomes included in-hospital mortality and complications.ResultsOf 559 children included, 70 (13%) received prehospital transfusions. In the unmatched cohort, the PHT and EDT groups had comparable age (median [IQR], 47 [9-16] vs 14 [9-17] years), sex (46 [66%] vs 337 [69%] were male), and insurance status (42 [60%] vs 245 [50%]). The PHT group had higher rates of shock (39 [55%] vs 204 [42%]) and blunt trauma mechanism (57 [81%] vs 277 [57%]) and lower median (IQR) Injury Severity Score (14 [5-29] vs 25 [16-36]). Propensity matching resulted in a weighted cohort of 207 children, including 68 of 70 recipients of PHT, and produced well-balanced groups. Both 24-hour (11 [16%] vs 38 [27%]) and in-hospital mortality (14 [21%] vs 44 [32%]) were lower in the PHT cohort compared with the EDT cohort, respectively; there was no difference in in-hospital complications. Mixed-effects logistic regression in the postmatched group adjusting for the confounders listed above found PHT was associated with a significant reduction in 24-hour (adjusted odds ratio, 0.46; 95% CI, 0.23-0.91) and in-hospital mortality (adjusted odds ratio, 0.51; 95% CI, 0.27-0.97) compared with EDT. The number needed to transfuse in the prehospital setting to save 1 child’s life was 5 (95% CI, 3-10).Conclusions and RelevanceIn this study, prehospital transfusion was associated with lower rates of mortality compared with transfusion on arrival to the emergency department, suggesting bleeding pediatric patients may benefit from early hemostatic resuscitation. Further prospective studies are warranted. Although the logistics of prehospital blood product programs are complex, strategies to shift hemostatic resuscitation toward the immediate postinjury period should be pursued.
Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria
Authors: Chia Nicholas H. , McKeon Andrew , Dalakas Marinos C. , Flanagan Eoin P. , Bower James H. , Klassen Bryan T. , Dubey Divyanshu , Zalewski Nicholas L. , Duffy Dustin , Pittock Sean J. , Zekeridou Anastasia 
Published: May 2023

AbstractBackgroundStiff person spectrum disorder (SPSD) is heterogeneous, and accurate diagnosis can be challenging.MethodsPatients referred for diagnosis/suspicion of SPSD at the Mayo Autoimmune Neurology Clinic from July 01, 2016, to June 30, 2021, were retrospectively identified. SPSD diagnosis was defined as clinical SPSD manifestations confirmed by an autoimmune neurologist and seropositivity for high‐titer GAD65‐IgG (>20.0 nmol/L), glycine‐receptor‐IgG or amphiphysin‐IgG, and/or confirmatory electrodiagnostic studies (essential if seronegative). Clinical presentation, examination, and ancillary testing were compared to differentiate SPSD from non‐SPSD.ResultsOf 173 cases, 48 (28%) were diagnosed with SPSD and 125 (72%) with non‐SPSD. Most SPSD were seropositive (41/48: GAD65‐IgG 28/41, glycine‐receptor‐IgG 12/41, amphiphysin‐IgG 2/41). Pain syndromes or functional neurologic disorder were the most common non‐SPSD diagnoses (81/125, 65%). SPSD patients more commonly reported exaggerated startle (81% vs. 56%, p = 0.02), unexplained falls (76% vs. 46%, p = 0.001), and other associated autoimmunity (50% vs. 27%, p = 0.005). SPSD more often had hypertonia (60% vs. 24%, p < 0.001), hyperreflexia (71% vs. 43%, p = 0.001), and lumbar hyperlordosis (67% vs. 9%, p < 0.001) and less likely functional neurologic signs (6% vs. 33%, p = 0.001). SPSD patients more frequently had electrodiagnostic abnormalities (74% vs. 17%, p < 0.001), and at least moderate symptomatic improvement with benzodiazepines (51% vs. 16%, p < 0.001) or immunotherapy (45% vs. 13% p < 0.001). Only 4/78 non‐SPSD patients who received immunotherapy had alternative neurologic autoimmunity.InterpretationMisdiagnosis was threefold more common than confirmed SPSD. Functional or non‐neurologic disorders accounted for most misdiagnoses. Clinical and ancillary testing factors can reduce misdiagnosis and exposure to unnecessary treatments. SPSD diagnostic criteria are suggested.
A Prussian‐Blue Bifunctional Interface Membrane for Enhanced Flexible Al–Air Batteries
Authors: Wei Manhui , Wang Keliang , Zuo Yayu , Zhong Liping , Züttel Andreas , Chen Zhuo , Zhang Pengfei , Wang Hengwei , Zhao Siyuan , Pei Pucheng 
Published: May 2023

AbstractFlexible Al–air batteries have attracted widespread attention in the field of wearable power due to the high theoretical energy density of Al metal. However, the efficiency degradation and anodizing retardation caused by Al parasitic corrosion severely limit the performance breakthrough of the batteries. Herein, a Prussian‐blue bifunctional interface membrane is proposed to improving the discharge performance of hydrogel‐based Al–air battery. When a rational 12 mg·cm−2 membrane is loaded, the effect of anticorrosion and activation is optimal thanks to the formation of a stable and breathable interface. The results demonstrate that a flexible Al–air battery using the membrane can output a high power density of 65.76 mW·cm−2. Besides, the battery can achieve a high capacity of 2377.43 mAh·g−1, anode efficiency of 79.78%, and energy density of 3176.39 Wh·kg−1 at 10 mA·cm−2. Density functional theory calculations uncover the anticorrosion‐activation mechanism that Fe3+ with a large number of empty orbitals can accelerate electrons transfer, and nucleophilic reactant [FeII(CN)6]4− promotes the Al3+ diffusion. These findings are beneficial to the inhibition of interfacial parasitic corrosion and weakening of discharge hysteresis for flexible Al–air batteries.
A Donor‐π‐Acceptor Type Red Thermally Activated Delayed Fluorescence Emitter Featuring Spiro as the Bridge Exhibiting Aggregation‐Induced Emission Activity and Outstanding Efficiencies in Organic Light‐Emitting Diodes
Authors: Wang Hui , Chen Jia‐Xiong , Zhang Xi , Cheng Ying‐Chun , Fan Xiao‐Chun , Zhou Lu , Yu Jia , Wang Kai , Zhang Xiao‐Hong 
Published: May 2023

AbstractConstructing donor‐π‐acceptor (D‐π‐A)‐type molecular structures by employing a phenyl as the π‐bridge to link donor (D) and acceptor (A) units has been recognized as an effective way to develop highly efficient red thermally activated delayed fluorescence (TADF) organic light‐emitting diodes (OLEDs). However, flexible and relatively planar structures would open potential energy loss channels, such as nonradiative inactivation and aggregation‐induced triplet quenching processes. Here, a bulky spiro‐9,9′‐bifluorene unit is first implemented to serve as a bridging group to construct a D‐π‐A molecule, enabling it to have higher overall rigidity, more sufficient steric hindrance, prolonged molecule length, and obvious aggregation‐induced emission characteristics compared with a common phenyl bridge. As a result, energy dissipation routes are effectively relieved at the unimolecular level, together with mitigated interchromophore quenching, rendering a 100% photoluminescence quantum yield and a larger horizontal dipole ratio of 89%. The OLED based on 3‐(2‐(diphenylamino)‐9,9′‐spirobi[fluoren]‐7‐yl)dibenzo[a,c]phenazine‐11,12‐dicarbonitrile exhibits an excellent external quantum efficiency of nearly 37% at 612 nm, which is over 1.38‐fold enhancement compared with the phenyl bridge‐based control molecule. This work provides an instructive solution to design highly efficient red TADF emitters exploiting D‐π‐A‐type molecular structures.
Simultaneous Terahertz Pulse Generation and Manipulation with Spintronic Coding Surface
Authors: Chen Sai , Wang Hanchen , Liu Jingyu , Zhang Mingxuan , Chen Peng , Li Peiyan , Liu Zhongkai , Han Xiufeng , Wan Caihua , Yu Haiming , Zhang Yan , Wu Xiaojun 
Published: May 2023

AbstractThe utilization of spintronic terahertz (THz) emitters has a significant influence on broadband coherent spectroscopy and imaging at THz frequencies. By using femtosecond light to irradiate the spintronic heterostructures, spin currents from the ultrafast demagnetization effect can be transformed into charge currents through the inverse spin Hall effect, leading to the emission of THz waves. In this work, through the incorporation of sequential and inverse deposition of W‐Co20Fe60B20‐Pt heterostructure films, control is gained over the spin currents and THz waveforms, enabling it to achieve a 180° phase difference across a broad frequency spectrum while efficiently radiating THz waves. This, in turn, allows it to control the spatial phase of THz radiation. To test the device's capabilities, lithography‐based devices capable of focusing, producing vortexes, and dividing beams are manufactured. This investigation aims to advance the development of THz pulse sources while providing essential support for cutting‐edge technologies such as THz spectroscopy, high‐resolution imaging, and high‐speed communications.
Ti3C2 MXene Induced Efficient Electron Transfer over Bimetallic Sulfides and Layered Double Hydroxides
Authors: Wu Youlin , Li Teng , Jin Zhiliang 
Published: May 2023

AbstractWith a large specific surface area and remarkable electrochemical capabilities, NiAl‐LDH is widely used in photocatalysis. The electrochemical performance of NiAl‐LDH can be further improved by introducing the appropriate amount of Ti3C2 MXene by hydrothermal method. And NiAl‐LDH@Ti3C2 is simply compounded with ZnCdS in a certain ratio to obtain ZnCdS/NiAl‐LDH@Ti3C2. By studying different ratios of ZCSNAT, the optimal ratio of hydrogen evolution activity is 27.10 mmol g−1 h−1 under alkaline solution, which is 9.96 and 1.67 times higher than ZCS and ZnCdS/NiAl‐LDH‐20, while ZnCdS/NiAl‐LDH@Ti3C2‐20 reaches 1883 µmol (37.66 mmol g−1 h−1) in acidic solution, 13.84 and 2.32 times higher than ZnCdS and ZnCdS/NiAl‐LDH‐20. This apparent enhancement is mainly due to the doping of Ti3C2 in the NiAl‐LDH preparation to achieve improved electrochemical properties of NiAl‐LDH. The better electron induction effect of NiAl‐LDH@Ti3C2 greatly improves the electron mobility to the NA surface, which results in a higher photogenerated electron–hole separation efficiency of the composite catalyst based on the original one.
Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte
Authors: Zhao Shiting , Nie Tao , Li Lei , Long Qiaoyun , Gu Ping , Zhang Yuwei , Sun Wei , Lin Zexin , Liu Qing , Qi Yue , Wang Wei , Xie Mengyuan , Loomes Kerry , Cai Chenleng , Wu Donghai , Hui Hannah Xiaoyan 
Published: May 2023

AbstractPRDM16 (PR domain containing protein 16) serves as a dominant activator of brown and beige adipocyte. However, mechanisms underlying the regulation of PRDM16 expression are incompletely understood. A Prdm16 luciferase knockin reporter mouse model is generated, enabling high throughput monitoring of Prdm16 transcription. Single clonal analysis reveals high heterogeneity of Prdm16 expression in the inguinal white adipose tissue (iWAT) cells. Amongst all transcription factors, androgen receptor (Ar) shows the strongest negative correlation with Prdm16. A sex dimorphism for PRDM16 mRNA expression is present in human WAT, with female individuals exhibiting increased expression than males. Androgen‐AR signaling mobilization suppresses Prdm16 expression, accompanied by attenuated beiging in beige adipocytes, but not in brown adipose tissue. The suppressive effect of androgens on beiging is abolished upon overexpression of Prdm16. Cleavage under targets and tagmentation mapping reveals direct binding of AR within the intronic region of Prdm16 locus, whereas no direct binding is detected on Ucp1 and other browning‐related genes. Adipocyte‐selective deletion of Ar potentiates beige cell biogenesis whereas adipocyte‐specific overexpression of AR attenuates white adipose beiging. This study highlights an essential role of AR in negative regulation of PRDM16 in WAT and provides an explanation for the observed sex difference in adipose beiging.