bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of anti-ulcer activity of the leaf extract of Solanum pubescens willd. (Solanaceae) in Wistar albino Rats
Authors: Tyagi C K , Saha Satendra Kumar , Shah Sunil Kumar 
Published: September 2023

The present study showed that the methonolic extract of Solanum pubescens willd leaves possess Anti- ulcer in animal model. The anti-ulcer activity was evaluated against Pylorus ligated ulcers. Gastric ulcer disease is an imbalance between mucosal defense factors (bicarbonate, mucin, prostaglandin, nitric oxide, and other peptides and growth factors) and injurious factors (acid and pepsin). Oral administration of methanol extract of solanum pubescens willd at doses of 200 and 400mg/kg exhibited dose dependent inhibition percentage of 36.28% and 52.3% (p<0.001) respectively compared to the ulcer control, proving the anti-ulcer activity. The standard drug omeprazole (20mg/kg) exhibited percentage inhibition of 70% when compared with ulcer control. Extract treated and ulcer control group was compared with normal control group. Result showed a significant decrease in the ulcer development in the animal models (pylorus ligated model) used in the study. In pylorusligation, both the doses showed significantant ulcer activity by reduction in ulcer index, gastric volume, free acidity, total acidity as compared to the control group. The intensity of heamorrhage and lesions was significantly reduced upon pretreatment with the extract, revealing the protective effect of MESP. Flavonoids and tannins are the major constituents that are present in the leaves of Solanum pubescens willd which may be responsible for its Ulcer- protective and Anti- ulcer activity.
Keywords: Peptic ulcer, Solanum pubescens, Wistar rats, Acute Oral toxicity, ANOVA
A double-blind, placebo-controlled, randomized clinical trial to evaluate the efficacy and safety of Virulina® along with standard treatment as per hospital protocol for the treatment of novel coronavirus (COVID-19)
Authors: Sewda Dishya , Totade Manick , Vikram Baburao , Sharma Anil Kumar 
Published: September 2023

Background: There is a high priority for the treatment of mild or moderate COVID-19 in an outpatient setting.
Objective: To test the efficacy, safety and tolerability of Virulina® in mild or moderate COVID-19 patients.
Methods: We carried out a double-blind, placebo-controlled, randomized clinical trial involving adult (18-70yrs) mild or moderate COVID-19 patients, randomized 1:1 on Virulina® (3 gm, maximum 14 days) or placebo respectively along with standard-of-care. The primary endpoint was the time taken for nasopharyngeal swab RT-PCR to test negative. And the average change in the ordinal scale from the baseline scores on the eight-point WHO ordinal scale was assessed.
Results: 30 outpatients were selected between 13 July 2020 to 13 August 2020. 93.33% of Virulina® treated patients were virologically cured compared to 53.33% in the placebo group (p= 0.001). The disappearance rates of major symptoms were significantly high in Virulina® plus standard treatment group compared with standard treatment alone.
Conclusion: Virulina® meets the primary and secondary endpoint criteria and exhibits statistically significant efficacy for mild or moderate COVID-19 patients. It is efficacious, safe, and well-tolerated at the tested dosage of 3gm for a maximum of 14 days.
Keywords: COVID-19; herbal medicine; immunomodulation; clinical trial.
Pharmacokinetic and Pharmacodynamics Study of Multiple Oral Doses of Vildagliptin Sustained Release 100 Mg Tablets under the Fed State in Healthy Volunteers
Authors: Doshi Chetan , Sridhar S B , Birla Ashish , Prasad Ashish , Kadam Pramod , Warrier Sona 
Published: September 2023

This study evaluated the pharmacokinetic and pharmacodynamic profile of the vildagliptin 100 mg sustained release (SR) administered once daily compared to vildagliptin 50 mg immediate release (IR) administered twice daily in healthy, adult human subjects under fed conditions.
This was a randomized, balanced, open-label, two-treatment, two-period, two-sequence, crossover multiple oral dose study in healthy adult subjects under fed conditions. The subjects were randomized to receive either a test product, i.e., vildagliptin SR 100 mg once daily, or a reference product, i.e., vildagliptin 50 mg twice daily. The duration of the study was 25 days. The primary pharmacokinetic parameter evaluated was the area under the concentration-time curve for one dosing interval at steady-state (AUC0-τ, ss). Bioequivalence was determined by assessing whether the 90% confidence intervals (CIs) for the geometric mean ratio of test to reference drug fell within predefined margins of 80% −125% for AUC0-τ, ss. The pharmacodynamics parameters evaluated were percent dipeptidyl-peptidase-4 (DPP-4) inhibition and weighted average percent DPP-4 inhibition.
Forty healthy adult males completed the study. There was no significant difference between the pharmacokinetic and pharmacodynamic profiles in reference and test products. The mean ± standard deviation (SD) values of AUC0-τ, ss for test and reference product was 2689.06 ± 835.47 2875.57 ± 703.85 ng. hr/mL, respectively. The 90% CIs of geometric least-square means of test/reference ratio for AUC0-τ, ss with vildagliptin SR 100 mg tablet was 86.32-97.26% within the bioequivalence acceptance range. The test and reference product showed over 90% inhibition of DPP-4 activity with multiple doses. The weighted average percent of DPP-4 inhibition (0-24 hrs) was 92.66% with the test product and 93.26% with the reference product. Both products were well tolerated during the entire study period. No serious or life-threatening adverse events (AEs) were reported during the study.
The two formulations of vildagliptin, i.e., vildagliptin SR 100 mg once daily and vildagliptin 50 mg twice daily, demonstrated similar pharmacokinetic and pharmacodynamic profiles under fed conditions in healthy adult males. Both formulations were bioequivalent and well tolerated.
Green Movement di Ekowisata Subak Sembung Desa Peguyangan
Authors: Widana I Ketut Arta , Darma I Gusti Ketut Indra Pranata , Nuriawan I Nengah Alit , Ariputra I Putu Suyasa , Risadi Md Yudyantara 
Published: September 2023

Green Movement telah menjadi landasan penting dalam upaya global untuk melestarikan lingkungan dan mendorong praktik berkelanjutan. Dalam konteks ekowisata, Green Movement berperan krusial dalam mengajak masyarakat untuk terlibat aktif dalam pelestarian alam dan budaya melalui praktik yang ramah lingkungan. Artikel ini mengkaji implementasi Green Movement dalam ekowisata Subak Sembung, sebuah destinasi yang menggabungkan keanekaragaman hayati, keindahan alam, dan warisan budaya di Desa Peguyangan, Denpasar. Melalui pendekatan kualitatif, penelitian ini mendokumentasikan upaya konkret yang telah diambil untuk mengedukasi dan melibatkan masyarakat dalam praktik berkelanjutan. Dengan menganalisis partisipasi masyarakat, strategi pendidikan, serta dampak yang terlihat, artikel ini memberikan wawasan tentang bagaimana Green Movement menjadi pendorong utama di balik pengembangan ekowisata Subak Sembung. Hasil penelitian menunjukkan bahwa melalui pendidikan dan kampanye kesadaran, masyarakat setempat semakin memahami pentingnya pelestarian lingkungan dan keterlibatan dalam upaya ini. Pengalaman edukatif, seperti tur lingkungan dan kegiatan praktis, telah memberikan kesempatan bagi pengunjung dan masyarakat untuk belajar secara langsung tentang manfaat praktik berkelanjutan. Partisipasi aktif dalam kegiatan pelestarian, seperti penanaman pohon dan pengelolaan sampah, mencerminkan adopsi nilai-nilai Green Movement dalam kehidupan sehari-hari.

The Green Movement has become an important cornerstone of global efforts to make the environment a reality and promote sustainable practices. In the context of ecotourism, the Green Movement plays a crucial role in inviting the community to be actively involved in preserving nature and culture through environmentally friendly practices. This article reviews the implementation of the Green Movement in Subak Sembung ecotourism, a destination that combines biodiversity, natural beauty and cultural heritage in Peguyangan Village, Denpasar. Through a qualitative approach, this study documents the concrete efforts that have been taken to educate and engage communities in sustainable practices. By analyzing community participation, education strategies, and visible impacts, this article provides insight into how the Green Movement is the main driver behind the development of ecotourism in Subak Sembung.The results of the research show that through socialization and awareness campaigns, local communities are increasingly understanding the importance of environmental preservation and are involved in these efforts. Educational experiences, such as environmental tours and hands-on activities, have provided opportunities for visitors and the public to learn first-hand about the benefits of sustainable practices. Active participation in conservation activities, such as tree hiding and waste management, reflects the adoption of Green Movement values in everyday life.
Pelatihan Teknik Dongeng Sebagai Metode Pengajaran Orang Tua Kepada Anak di TK RA Mentari
Authors: Fauzia Nur , Fahri Fahri , Purwati Oikurema , Kuswardani Rahayu , Darma Fithriyah Inda Nur Abida Diana Budi 
Published: September 2023

Karya tulis ilmiah ini bertujuan untuk mengevaluasi efektivitas pelatihan teknik dongeng sebagai metode pengajaran orang tua kepada anak di TK RA Mentari. Metode yang digunakan adalah pendekatan campuran (mixed-methods) dengan menggabungkan data kualitatif dan kuantitatif. Populasi dalam kegiatan ini adalah seluruh orang tua dari anak-anak yang bersekolah di TK RA Mentari, dengan sampel penelitian dipilih secara purposif. Pelatihan teknik dongeng dilaksanakan untuk meningkatkan keterampilan dan pengetahuan orang tua dalam menggunakan dongeng sebagai alat pengajaran kepada anak-anak. Hasil analisis data menunjukkan adanya peningkatan yang signifikan pada keterampilan orang tua setelah mengikuti pelatihan. Orang tua mampu mengintegrasikan teknik dongeng dengan kreativitas dan efektivitas dalam aktivitas pembelajaran bersama anak di rumah dan di sekolah. Dampak implementasi teknik dongeng oleh orang tua pada perkembangan anak juga diamati melalui observasi perilaku anak di kelas dan wawancara dengan guru atau pengasuh. Hasilnya menunjukkan bahwa anak-anak yang memiliki orang tua yang aktif dalam menggunakan teknik dongeng menunjukkan peningkatan dalam perkembangan bahasa, moral, dan imajinasi. Pelatihan teknik dongeng sebagai metode pengajaran orang tua kepada anak di TK RA Mentari memberikan dampak positif dan signifikan dalam pendidikan anak usia dini.

This scientific paper aims to evaluate the effectiveness of storytelling technique training as a method of teaching for parents to their children at TK RA Mentari (Mentari Kindergarten). The method used is a mixed-methods approach, combining qualitative and quantitative data. The population of this study consists of all parents of children attending TK RA Mentari, with the research sample chosen purposively. The storytelling technique training was conducted to enhance the skills and knowledge of parents in using storytelling as a teaching tool for their children. The results of data analysis indicate a significant improvement in the skills of parents after attending the training. Parents were able to integrate storytelling techniques creatively and effectively in learning activities with their children at home and at school. The impact of implementing storytelling techniques by parents on children's development was also observed through the observation of children's behavior in the classroom and interviews with teachers or caregivers. The results showed that children with parents actively using storytelling techniques demonstrated improvements in language, moral, and imaginative development. Storytelling technique training as a method of teaching for parents at TK RA Mentari provides a positive and significant impact on early childhood education.
Blocking Hemopexin With Specific Antibodies: A New Strategy for Treating Diabetic Retinopathy
Authors: Bogdanov Patricia , Duarri Anna , Sabater David , Salas Anna , Isla-Magrané Helena , Ramos Hugo , Huerta Jordi , Valeri Marta , García-Arumí José , Simó Rafael , Hernández Cristina 
Published: September 2023

Hemopexin (HPX) is overexpressed in the retina of patients with diabetes and induces the breakdown of the blood-retinal barrier in vitro. The aim of this study was to evaluate whether HPX blockade by specific antibodies (aHPX) could avoid vascular leakage in vivo and microvascular angiogenesis in vitro and ex vivo. For this purpose, the effect of intravitreal (IVT) injections of aHPX on vascular leakage was evaluated in db/db mice and rats with streptozotocin-induced diabetes using the Evans Blue method. Retinal neurodegeneration and inflammation were also evaluated. The antiangiogenic effect of aHPX on human retinal endothelial cells (HRECs) was tested by scratch wound healing and tube formation using standardized methods, as well as by choroidal sprouting assays from retinal explants obtained in rats. We found that IVT injection of aHPX significantly reduced vascular leakage, retinal neurodegeneration, and inflammation. In addition, treatment with aHPX significantly reduced HREC migration and tube formation induced by high glucose concentration and suppressed choroidal sprouting even after vascular endothelial growth factor stimulation, with this effect being higher than obtained with bevacizumab. The antipermeability and antiangiogenic effects of IVT injection of aHPX suggest the blockade or inhibition of HPX as a new strategy for the treatment of advanced stages of diabetic retinopathy.

Article Highlights
Hemopexin (HPX) is the best-characterized permeability factor in steroid-sensitive nephrotic syndrome. We have previously reported that HPX is overexpressed in the retina of patients with diabetes and induces the breakdown of the blood-retinal barrier in vitro. Here, we report that intravitreal injection of anti-HPX antibodies significantly reduces vascular leakage, retinal neurodegeneration, and inflammation in diabetic murine models and that the immunoneutralization of HPX exerts a significant antiangiogenic effect in vitro and in retinal explants. The blockade of HPX can be considered as a new therapy for advanced stages of diabetic retinopathy.
Identifying drivers of food insecurity through linked data- the Priority Places for Food Index
Authors: Pontin Francesca , Baudains Peter , Ennis Emily , Morris Michelle 
Published: September 2023

Introduction & Background15.5% of all UK households are food insecure; either unable to afford to eat, skipping meals or reducing meal sizes despite being hungry. Drivers of food insecurity include both access to and affordability of food, with those most in need often left unable to access healthy and affordable food. Taking a place-based approach to understand the drivers of food insecurity allows for targeted support from government, third sector and private organisations to mitigate growing food insecurity in the UK.
Objectives & ApproachThis research presents the methodology for the co-production and construction of the Priority Places for Food Index (PPFI) and supporting dashboard, co-designed by the Consumer Data Research Centre (CDRC) and consumer champions Which? in response to the 'cost-of-living crisis'.
The PPFI equally weights measures of access to affordable food and indicators of barriers to affording food across seven domains; Proximity to supermarket retail facilities, Accessibility of supermarket retail facilities, Access to online deliveries, Proximity to non-supermarket food provision, Socio-economic barriers, Fuel Poverty and Family Food for support. The PPFI uses open data combing traditional census data metrics, with government data (e.g., Healthy start voucher and free-school meals uptake), digital footprints data (web-scraped delivery addresses and food bank item request data) and scaled-survey data (fuel poverty, propensity to shop online).
Relevance to Digital FootprintsDigital footprint data can complement traditional data sources to provide a more nuanced view of health inequalities. These data are typically less timely to collect than traditional data collection methods (census, survey) allowing a more reactive response to emergent issues such as the cost-of-living crisis.
ResultsThe PPFI interactive map and underlying data have been published via the CDRC https://priorityplaces.cdrc.ac.uk/.
Conclusions & ImplicationsWe demonstrate the value of data linkage across individual and population level data to provide localised insight into food insecurity and identify where digital footprints data can improve gaps in the current evidence base. We also reflect on the value of co-production and stakeholder engagement in creating a policy ready interactive map which has facilitated the lobbying of targeted practical support and policy change to address food insecurity.
Seasonal purchase of antihistamines and ovarian cancer risk in the Cancer Loyalty Card Study (CLOCS): results from an observational case-control study
Authors: Brewer Hannah , Jiang Qianhui , Sundar Sudha , Hirst Yasemin , Flanagan James 
Published: September 2023

Introduction & BackgroundAntihistamine use has been associated with a reduction in ovarian cancer incidence. Herein, we investigate antihistamine exposure in relation to ovarian cancer risk using a novel data resource by examining purchase histories from retailer loyalty card data.
Objectives & ApproachParticipants from the Cancer Loyalty Card Study (CLOCS) included ovarian cancer patients (cases, n=153) and women without a diagnosis of ovarian cancer (controls, n=120). Up to 6 years of purchase history was retrieved from two participating high street retailers from 2014-2022. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals for ovarian cancer associated with antihistamine purchases, adjusting for confounders. The association was stratified by season of purchase, age, histology, and family history.
Relevance to Digital FootprintsThis study is one of the first to utilise transaction data from high street retailers to investigate associations with cancer risk, based on what participants are buying.
ResultsEver purchasing antihistamines was not significantly associated with ovarian cancer overall in this small study (OR=0.68 (0.39-1.19)). However, antihistamine purchases were significantly associated with reduced ovarian cancer risk when purchased only in spring and/or summer (OR=0.37 (0.17-0.82)) and in non-serous ovarian cancer (OR=0.41 (0.18-0.93)) in stratified analyses.
Conclusions & ImplicationsAntihistamine purchase is associated with reduced ovarian cancer risk when purchased seasonally. However, larger studies are required to understand the mechanisms of reduced ovarian cancer risk related to seasonal purchases of antihistamines and allergies.
KAJIAN Bacillus thuringiensis DIPERBANYAK PADA MEDIA PADAT HASIL SAMPING AGROINDUSTRI TERHADAP MORTALITAS LARVA Oryctes rhinoceros DI RUMAH BAYANG
Authors: Pujiastuti Yulia , Hakari Irfan Mohandis , SHK Suparman , Umayah Abu , Gunawan Bambang , Herlin Weri 
Published: September 2023

Hama Oryctes rhinoceros (Coleoptera:Scarabaeidae) merupakan hama penting pada kelapa sawit. Pengendalian secara terpadu dan berkelanjutan harus senantiasa dilakukan. Penggunaan bakteri entomopatogen Bacillus thuringiensis menjadi alternatif bagi pengendalian kimiawi. Tujuan penelitian untuk mempelajari efektivitas B. thuringiensis yang diperbanyak dengan bahan limbah padat terhadap mortalitas O. rhinoceros. Percobaan dirancang dengan Rancangan Acak Kelompok dan dilakukan di rumah bayang, dengan 6 perlakuan meliputi : P1: onggok + bungkil kelapa sawit (2:1), P2: onggok + ampas tahu (2:1), P3 : onggok + bungkil kacang tanah (2:1), P4 : onggok + ampok jagung (2:1), P5 (kontrol air), P6 (kontrol insektisida) dan dilakukan sebanyak 4 ulangan. Serangga uji berupa larva Oryctes instar 3, sebanyak 10 ekor per ulangan. Keadaan di rumah bayang dengan suhu udara berkisar 25,1˗40,2 oC dan kelembaban udara 52,9˗99%. Mortalitas larva tertinggi pada hari ke 20 (82,50 %) pada perlakuan P1 (onggok+bungkil kelapa sawit, 2:1), dan terendah pada P3 (onggok + bungkil kacang tanah, 2:1) (47.5%). Larva yang tetap hidup menunjukkan gejala penurunan berat dan panjang tubuh. Gejala infeksi berupa perubahan warna tubuh, tidak aktif dan gejala kematian berupa tubuh lunak dan berair. Penggunaan B. thuringiensis sebagai agens pengendali hama merupakan cara pengendalian yang prospektif.
ETIKA KOMUNIKASI PERSPEKTIF AL-QUR’AN: TELAAH KRITIS SOLUSI MENGATASI PROBLEMATIKA HOAX DI MEDIA SOSIAL
Authors: Irhamdi Muhamad 
Published: September 2023

Abstract. The insistence of the flow of social media must be acknowledged that it brings various consequences in the line of life that must be borne by modern civilization. In addition to offering as an enjoyment of life that tends to be material and physical, social media has brought many negative impacts, especially in the social area. Good communication ethics over time and changing times have eroded. The number of hoax news that is scattered in the media seems to be human food for social media users. The contextualization of the holy book (al-Qur'an) today is the right answer to this modern problem. the main focus in this research is tracking the deep communication ethics of the Qur'an as a solution in responding to the problem of hoaxes on social media. The type of research used is library research, namely research that is used to solve conceptual-theoretical problems. The data sources used in this paper are primary and secondary sources. The analytical method of writing this work is descriptive-analytical.
Keywords: Al-Qur'an, Problematics, Social Media
KONSEP DAKWAH TOLERANSI USTADZ MUHAMMAD BASYIRUDIN PADA MASYARAKAT PLURAL
Authors: Fatulloh M Amin 
Published: September 2023

Abstrak;
Artikel ini ditulis dengan tujuan untuk memberikan sebauh gambaran untuk para da’i mengenai konsep dakwah tentang toleransi jika menghadapi madd’u/masyarakat yang plural dan menjadi sebuah solusi untuk memberikan suatu konsep dakwah toleransi pada setiap ustadz di pendesaan, manfaat penelitian ini guna untuk masyarakat plural serta organisasi yang bersangkutan dengan toleransi. Dalam peneitian ini menggunakan metode kualitatif dengan mendapatkan sumber dari lapangan melalui wawancara terhadap yang bersangkutan. Hasi dari penelitian ini adalah konsep yang digunakan oleh ustadz Muhammad Basyirudin dalam dakwah toleransi pada masyaraat plural adalah konsep dakwah ramah, konsep tolong menolong, konsep menerima pendapat orang lain, konsep tidak ikut campur dalam urusan agama, dan konsep mencintai dengan tidak menghakimi.
Kata Kunci; Konsep Dawah, Toleransi, Masyarakat Plural