bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling
Authors: Kurniansyah Nuzulul , Wallace Danielle A. , Zhang Ying , Yu Bing , Cade Brian , Wang Heming , Ochs-Balcom Heather M. , Reiner Alexander P. , Ramos Alberto R. , Smith Joshua D. , Cai Jianwen , Daviglus Martha , Zee Phyllis C. , Kaplan Robert , Kooperberg Charles , Rich Stephen S. , Rotter Jerome I. , Gharib Sina A. , Redline Susan , Sofer Tamar 
Published: January 2023

AbstractSleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis. We develop genetic instrumental variables for the associated transcripts as polygenic risk scores (tPRS), then generalize and validate the tPRS in the Women’s Health Initiative. We measure the associations of the validated tPRS with SDB and serum metabolites in Hispanic Community Health Study/Study of Latinos. Here we find differential gene expression by blood cell type in relation to SDB traits and linkP2XR4expression to average oxyhemoglobin saturation during sleep and butyrylcarnitine (C4) levels. These findings can be used to develop interventions to alleviate the effect of SDB on the human molecular environment.
Culturally Responsive Guidelines for Serving Families of Bilingual Children Who Stutter
Authors: Souza Mumy Ana Paula G. 
Published: January 2023

Purpose:
Speech-language pathologists (SLPs) encounter an increase in the cultural and linguistic diversity in their caseloads each year. This has given rise to challenges that SLPs working with bilingual children face, particularly in relation to language choice. Professionals and families must make complex educational and intervention decisions. The purpose of this tutorial is to assist SLPs in developing their cultural responsiveness as it pertains to working with bilingual families, with a special focus on bilingual children who stutter. The vital role of the home language will be discussed as well as the far-reaching detrimental effects of removing or reducing use of the home language within the family unit. We will examine the available research on bilingualism and stuttering as well as its complexities.

Conclusions:
Each case we encounter must be filtered through principles that keep the family's cultural and linguistic background central in decision-making. Guiding principles, viable solutions, and practical recommendations for working with bilingual children who stutter and their families are introduced and discussed.
A compact broadband antenna for ultra high frequency and L band on 5G new radio base stations
Authors: Cui Yuehui , Tu Zhenxing , Qin Yue , Li RongLin 
Published: January 2023

AbstractA simple method is proposed for the realisation of compact dual‐polarised antennas. The aperture area of a dual‐polarised dipole antenna can be reduced by half by surrounding the antenna with a square loop. Based on the method, a broadband compact dual‐polarised antenna is developed. The broadband dual‐polarised antenna consists of two ±45°‐polarised dipoles surrounded by a square loop and fed by two orthogonal broadband baluns. A resonance at a sfrequency (fLr = 0.7 GHz) is created by the square loop, leading to a compact size of about λLr/4 × λLr/4, where λLr is the wavelength in free space at fLr. Another resonance at a higher frequency (fHr = 1.5 GHz) is generated by etching open slots on the ±45°‐polarised dipoles. A combination of the lower‐frequency and the higher‐frequency resonances results in a broadband operation. Simulation and experimental results show that the compact dual‐polarised antenna achieves an impedance bandwidth of 75% (0.69–1.52 GHz) for return loss > 15 dB with stable radiation patterns, which is potential to be used for 5G new radio base‐station applications.
Identification of late-type Class I stars using Gaia DR3 Apsis parameters
Authors: Messineo Maria 
Published: January 2023

Aims. We examined the Gaia DR3 GSP-Phot and GSP-Spec parameters of known K- and M-type stars of Class I luminosity to make a comparison with the parameters collected from the literature to assess their accuracy and their potential in setting stellar classifications of intrinsically bright late-types that have been unknown thus far. Gaia DR3 GSP-Phot and GSP-Spec parameters were generated by the astrophysical parameters inference software (Apsis).
Methods. In the Gaia DR3 catalog, there are about 40,000 entries with Apsis parameters that are similar to those of known red supergiants (RSGs), good parallaxes, and infrared 2MASS and WISE data. In using parallactic distances, infrared photometry, and variability information, only 203 new entries were found with luminosities and temperatures similar to that of known RSGs and G-band amplitudes smaller than 0.5 mag. Their low-resolution BP/RP spectra were compared with an empirically built spectral library of BP/RP spectra of known bright late-type stars, including C-rich, S-type, O-rich asymptotic giant branch stars (AGBs) and RSGs, to obtain their spectral types.
Results. Among them, 15 S-type stars were identified based on peculiar absorption features attributed to ZrO and LaO visible in their BP/RP spectra, along with 1 S/C star and 9 C-rich stars by their strong CN absorption bands. K- and M-types can be reproduced with an accuracy of two subtypes. In addition, 20 new RSGs have been confirmed, of which 6 have bolometric magnitudes that are brighter than those of the AGB limit: 2MASS J21015501+4517205, 2MASS J16291280-4956384, 2MASS J10192621-5818105, 2MASS J20230860+3651450, 2MASS J17084131−4026595, and 2MASS J16490055−4217328. The flag for C-rich stars of the Gaia DR3 LPV pipeline is erroneously positive for some RSGs and, thus, a visual inspection of the BP/RP spectra is mandatory.
Titan – ein zementierbarer Werkstoff für die Endoprothetik
Authors: Jaenisch Max , Wirtz Dieter Christian 
Published: January 2023

ZusammenfassungDie Vorteile von Titanlegierungen gegenüber den herkömmlichen Stahl-, Kobalt-Chrom- und
Chrom-Nickel-Legierungen als Material für Endoprothesen sind eine gute Dauerschwingfestigkeit,
eine exzellente Biokompatibilität, ein niedrigeres Elastizitätsmodul und eine hohe
Korrosionsbeständigkeit. Teilweise schlechte klinische Ergebnisse, vermutlich ausgelöst durch
Spaltkorrosion, haben jedoch zu einer verminderten Benutzung geführt. Um einen sicheren
Einsatz zu gewährleisten, sollte das Design optimiert werden (ausreichender proximaler
Durchmesser, proximaler Kragen), um übermäßige Verformungen besonders im proximalen Anteil zu
reduzieren, und auf eine raue Oberfläche (Ra > 2,5 µm) verzichtet werden. Eine
Weiterführung der Forschung über Oberflächenbearbeitung, wie z. B. eine
Silikat-/Silan-Beschichtung, könnte weitere Verbesserungen bewirken.
Methacholine and FeNO Measurement in Patients with Habit
Cough
Authors: Woelke Sandra , Szelenyi Alexandra , Dreßler Melanie , Trischler Jordis , Donath Helena , Hutter Martin , Blümchen Katharina , Zielen Stefan 
Published: January 2023

Abstract
Background Chronic cough is one of the most common symptoms in childhood.
Making a definite diagnosis is a challenge for all pediatricians especially in
patients when cough is without an organic cause like in habit cough.
Patients and Methods In this retrospective analysis, all electronic
outpatient charts of the Division of Allergology and Pneumology, between January
1, 2010 and December 31, 2019 were reviewed in order to study all children with
potential habit cough. All children underwent the following diagnostic
algorithms, skin prick test (SPT), measurement of fractional exhaled nitric
oxide (FeNO), spirometry and methacholine challenge test (MCT). The value of a
normal MCT and FeNO measurement for diagnosing habit cough was investigated.
Results The chart review revealed 482 patients with chronic
cough>4 weeks. Of these, 99 (20.5%) with suspected habit cough
were collected. 13 patients had to be excluded for other diagnosis and a
complete data set was available in 55 patients. 33 (60.0%) of 55
patients were SPT negative and 22 (40.0%) had sensitization to common
allergens. Five patients had elevated FeNO≥20 ppb and three showed
severe bronchial hyperresponsiveness<0.1 mg methacholine,
challenging the diagnosis of habit cough.
Conclusion A normal FeNO and MCT can help confirm the clinical diagnosis
of habit cough. However, in patients with positive MCT and/or elevated
FeNO habit cough can be present. Especially in patients with elevated FeNO and
severe BHR cough variant asthma and eosinophilic bronchitis have to be ruled
out.
Efficient and Scalable Syntheses of 1,2-Thiaselenane-4-amine and 1,2-Thiaselenane-5-amine
Authors: Zeisel Lukas , Thorn-Seshold Oliver , Maier Martin S. 
Published: January 2023

AbstractThe first regioselective syntheses of 1,2-thiaselenane-4-amine (TSA4) and 1,2-thiaselenane-5-amine (TSA5) are developed. Both are redox motifs with high value in chemical biology that until now were hindered by tedious synthesis. An aziridine intermediate and a kinetically controlled S-acylation were leveraged for regioselective chalcogen installations. Short, fast sequences were optimised with just one or two chromatographic steps that cheaply deliver these motifs on scale for high throughput inhibitor screening, and thus provide a robust methodology for assembling other selenenyl sulfides.
Synthesis of Polycyclic Imidazoles via α-C–H/N–H Annulation of Alicyclic Amines
Authors: Dutta Subhradeep , Bhatt Kamal , Seidel Daniel , Cuffel Fabian 
Published: January 2023

AbstractSecondary alicyclic amines are converted into their corresponding ring-fused imidazoles in a simple procedure consisting of oxidative imine formation followed by a van Leusen reaction. Amines with an existing α-substituent undergo regioselective ring-fusion at the α′-position. This method was utilized in a synthesis of fadrozole.
Association between Elevated Intrauterine Resting Tone during Labor and Neonatal Morbidity
Authors: Rimsza Rebecca R. , Raghuraman Nandini , Carter Ebony B. , Kelly Jeannie C. , Cahill Alison G. , Frolova Antonina I. 
Published: January 2023

Objective Internal contraction monitoring provides a quantitative assessment of intrauterine resting tone. During the course of labor, elevated intrauterine resting tone may be identified. We hypothesized that elevated intrauterine resting tone could lead to compression of the spiral arteries, thus limiting uterine blood flow and resulting in neonatal compromise. Therefore, our objective was to assess the association between elevated resting tone during labor and neonatal morbidity.
Study Design This was a secondary analysis of a prospective cohort study of singleton deliveries at ≥37 weeks of gestation. Patients with ruptured membranes and an intrauterine pressure catheter in place for at least 30 minutes prior to delivery were included. Intrauterine resting tone was calculated as the average baseline pressure between contractions during the 30 minutes prior to delivery. The study group had elevated intrauterine resting tone, defined as intrauterine resting tone ≥75th percentile (≥12.3 mm Hg). Primary outcome was composite neonatal morbidity: hypoxic–ischemic encephalopathy, hypothermia treatment, intubation, seizures, umbilical arterial pH ≤7.1, oxygen requirement, or death. Secondary outcomes included umbilical artery pH <7.2, lactate ≥4 mmol/L, and rates of neonatal intensive care unit admission.
Results Of the 8,580 patients in the cohort, 2,210 (25.8%) met the inclusion criteria. The median intrauterine resting tone was 9.7 mm Hg (interquartile range: 7.3–12.3 mm Hg). Elevated resting tone was associated with a shorter median duration of the first stage of labor (10.0 vs. 11.0 hours, p < 0.01) and lower rates of labor induction and oxytocin augmentation (p < 0.01). Neonatal composite morbidity was higher among patients with elevated intrauterine resting tone (5.1 vs. 2.9%, p = 0.01). After adjusting for chorioamnionitis and amnioinfusion, elevated intrauterine resting tone was associated with increased risk of neonatal morbidity (adjusted odds ratio: 1.70, 95% confidence interval: 1.06–2.74).
Conclusion Our findings suggest that elevated intrauterine resting tone is associated with increased risk of neonatal composite morbidity.
Key Points
Risk Factors for Keratoconus Progression in Children Compared with Young and Middle-aged Adults
Authors: Sideroudi Haris , Flockerzi Elias , Jullien Theresia , Hamon Loïc , Seitz Berthold 
Published: January 2023

Abstract
Background To investigate the risk factors for keratoconus progression in children (10 – 18 years old; age group 1) compared to young adults (19 – 35 years old; age group 2) and
middle-aged adults (36 – 55 years old; age group 3).
Patients/Methods Ninety-seven children, 445 young adults, and 342 middle-aged adults underwent total ophthalmic examination including clinical refraction, slit lamp examination,
corneal tomography, eye biometry, and biomechanical properties measurements. Comparisons were assessed among three age groups and between progressive and nonprogressive eyes. Logistic
regression was applied to determine the potential prognostic factors for keratoconus progression in the three age groups.
Results Univariate logistic regression analysis show that the most prominent factors associated with progression were corneal posterior vertical radius (RVP), eye rubbing (RUB), slit
lamp corneal thinning (SLT), contact lens use (CL), and central corneal thickness (CCT) in all age groups. Additionally, the anterior chamber volume (ACV) and keratoconus match index (KMI)
were associated with progression in age group 1. Location of the thinnest corneal thickness at the vertical axis (TCTy), distance from apex to the thinnest point (BADISTAPEX), scissor
reflection in retinoscopy (SKIAREFLEX), and Vogt striae were associated with progression in age group 2, and TCTy, anterior and posterior asphericity (ASPA and ASPP, respectively),
BADISTAPEX, SKIAREFLEX, and Vogt striae were associated with progression in age group 3. The multivariate model with the highest predictability indicated RVP, ACV, and SLT as independent
determinants of progression in age group 1 (AUC: 90%, sensitivity: 88.9%, specificity: 90.9%), RVP, ACV, SLT, and SKIAREFLEX in group 2 (AUC: 81.6%, sensitivity 88.5%, specificity: 70.3%),
and RVP, SLT, Vogt striae, and CL in age group 3 (AUC: 80%, sensitivity 82.8%, specificity: 73%).
Conclusion ACV and KMI seem to play a major role in the progression of pediatric KC compared to adults. This is probably due to different anatomical and biomechanical characteristics
of a childʼs eye globe.
Cluster of Differentiation 44 Expression in Gastrointestinal Malignancies: A Study from South India
Authors: Bhavikatti Ayesha , Channigaramaiah Guruprasad , Chikkannaiah Panduranga , Venkataramanappa Srinivasamurthy 
Published: January 2023

Abstract
Introduction Cancer stem cell markers are now being tried in various cancers as prognostic markers including GI cancer but these kinds of studies are sparse in Indian population.
Materials and Methods This study conducted over a period 50 months. Hematoxylin and eosin-stained slides were screened for grading of the tumor, extent of invasion of tumor, confirmation of metastasis, and staging was done. Immunohistochemical expression of CD44 was graded on the basis of percentage of tumor cells positive for staining. Statistical analysis was done and results were tabulated.
Results: A total of 40 cases of GI cancer were studied. Ascending colon (37.5%) was the common site involved, 37 cases (92.5%) showed invasion beyond the muscularis externa. Most tumors were poorly differentiated (37.5%). Also, 50% of lymph nodes showed tumor deposits. The majority of the cases were in stage II (40%). There was a significant correlation between histopathological type of differentiation with lymph node metastasis and staging of tumor, lymph node metastasis also had significant association with staging.Grade 2, CD 44 expression was most common followed by Grade 3. Significant association was observed between histopathological differentiations of tumor with CD44 expression. Tumors that are invading beyond muscularis externa and lymph node-positive cases showed moderate to high CD44 expression.
Conclusion CD44 expression was significantly noted in poorly differentiated tumors. Increased expression was also noted in cases of tumors invading beyond muscularis externa and lymph node metastasis. Combination of CSC markers will increase the sensitivity and specificity and predict better overall survival in GI tumors.
Laparoscopic Heller–Dor Is a Persistently Effective Treatment for Achalasia Even in Pediatric Patients: A 25-Year Experience at a Single Tertiary Center
Authors: Provenzano Luca , Pulvirenti Rebecca , Duci Miriam , Capovilla Giovanni , Costantini Andrea , Forattini Francesca , Gamba Piergiorgio , Costantini Mario , Fascetti-Leon Francesco , Salvador enato 
Published: January 2023

AbstractBackground Esophageal achalasia (EA) is a rare primary motility disorder in any age group, and particularly rare in the pediatric population, with a reported incidence of 0.18 per 100,000 children a year. EA in pediatric age is currently treated in the same way as in adults, but this approach is based on only a few studies on small case series. The aim of this retrospective study was to assess the long-term outcome of the laparoscopic Heller–Dor (LHD) procedure when performed in pediatric patients with EA at our university hospital.Materials and Methods We considered children and adolescents younger than 16 years old diagnosed with EA and treated with LHD between 1996 and 2022. Clinical data were prospectively collected in an ongoing database. Symptoms were recorded and their severity was calculated using the Eckardt score. Barium swallow, esophageal manometry (conventional or high-resolution), and endoscopy were performed before and after the surgical procedure.Results During the study period, 40 children with a median age of 14 years (interquartile range [IQR]: 11–15) underwent LHD. At a median follow-up of 10.5 years (IQR: 4.5–13.9), a good outcome was achieved in 36/40 patients (90%). Two of the four patients whose surgical procedure failed underwent complementary pneumatic dilations successfully, thus increasing the overall success rate to 95%. A previous endoscopic treatment (in five patients) did not affect the final outcome (p = 0.49). An intraoperative mucosal lesion was detected in only one patient (2.5%) and was repaired at the time without further consequences. During the follow-up, 22 patients underwent endoscopy, and 17 had pH monitoring as well: only 2 of these patients showed reflux esophagitis at endoscopy (one of them with abnormal findings on pH monitoring), amounting to a 9.1% rate of instrumentally confirmed postoperative reflux.Conclusion LHD is a safe and persistently effective treatment for EA in pediatric age, with a success rate comparable with what is usually obtained in adults, and better than what has been reported to date in the pediatric literature. Adding a fundoplication certainly helps ensure an optimal long-term control of any gastroesophageal reflux induced by the myotomy.
Association of Renal Function (Estimate Glomerular Filtration Rate) with the Number of Febrile Urinary Tract Infections in Children with Neurogenic Bladder
Authors: Zhou Guanglun , Jiang Man , Zhu Wenbin , Liu Xiaodong , Sun Junjie , Li Shoulin 
Published: January 2023

Abstract
Introduction Our objective was to evaluate whether renal function, assessed as the estimated glomerular filtration rate (eGFR), is associated with the number of febrile urinary tract infections (FUTIs) in children diagnosed with neurogenic bladder (NB).
Materials and Methods Clinical information of patients diagnosed with NB was prospectively collected between January 2013 and January 2022. Episodes of FUTI were recorded during the follow-up period, and the eGFR was calculated based on the serum cystatin C level. Grading (G1–G5) of chronic kidney disease (CKD) was conducted as described by the eGFR.
Results In total, 463 children were included in the final analysis (265 males and 198 females; mean age: 23 months). The median follow-up time was 51 months. A total of 302 children had four or more FUTIs and 161 children had none to three FUTIs. The incidence of developing CKD G3 to G5 gradually increased from the first to third (1.3–2.4%) episodes of FUTI and drastically increased after four episodes (≥ 22.5%), with the incidence recorded to be 100% after eight FUTIs. The odds of CKD G3 to G5 in children with four FUTIs were 17.3 and 43.7 times greater after four and six FUTIs, respectively, than in children with one FUTI.
Conclusion This study showed that recurrent FUTIs are common in children with NB and that the risk of rapid progression to CKD G3 to G5 increases substantially after four or more FUTIs episodes.
Evaluation of the Efficacy of Human Dental Pulp Stem Cell Transplantation in Sprague–Dawley Rats with Sensorial Neural Hearing Loss
Authors: Rawiwet Visut , Vijitruth Rattanavijit , Thonabulsombat Chareonsri , Vongsavan Kutkao , Sritanaudomchai Hathaitip 
Published: January 2023

AbstractObjectives The purpose of the present study was to evaluate the efficacy of spiral ganglion neuron (SGN) regeneration after dental pulp stem cell (DPSC) transplantation in a rat sensorineural hearing loss (HL) model.Materials and Methods Sham or experimental HL was induced in adult Sprague–Dawley rats by cochlear round window surgery. An HL rat model was established with a single 10 mM ouabain intratympanic injection. After 7 days, the rats received DPSCs, stem cells from human exfoliated deciduous teeth (SHED), or culture medium in the sutural area to establish four groups: sham, HL-DPSC, HL-SHED, and HL-medium. Histological analyses were performed at 4, 7, and 10 weeks after transplantation, and the number of SGNs, specific SGN protein expression, and the function of SGNs were evaluated.Statistical Analysis Data were statistically by MS Excel and SPSS v.15.0. Intergroup level of significance was determined via a one-way analysis of variance and Duncan's multiple range test with 95% confidence intervals.Results New SGN formation was observed in the HL-DPSC and HL-SHED rat groups. The number of SGNs was significantly higher in the HL-DPSC and HL-SHED groups than in the HL-medium group over 4 to 10-week survival period. HL-DPSC rats exhibited higher SGN density compared with that in HL-SHED group, which was statistically significant at week 10. The regenerated SGNs expressed cochlear wiring regulator GATA-binding-protein 3. Moreover, the SGNs from the HL-DPSC group also exhibited a higher expression of synaptic vesicle protein and regulated action potential-dependent neurotransmitter release compared with SGNs from the HL-SHED group.Conclusions Our findings suggest that DPSCs and SHED repair and regenerate SGNs in rat HL model. Dental pulp stem cells represent a promising treatment strategy for restoring damage to the sensory circuits associated with deafness.