bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Proses Pengolahan Terhadap Kadar Fenol, Vitamin C dan Penerimaan Konsumen pada Teh Daun Tatat (Bauhinia acuminata)
Authors: Fitriarni Dian 
Published: August 2023

Human awareness to maintain health provides an increase in consumption of natural products. This requires various efforts to explore natural products and process them into functional food. Herbal tea is one type of functional food from plant are produces in form dried herbs plant. Tatat leaves is rich in bioactive compounds such as alkaloid and polyphenols. This are actually quite well known in Sandai, which are believed to treat heat, lower blood sugar, hypertension, and immunomodulators. The purposes of this study is to make tatat leaf tea as functional food products with good quality especially for compotition and consumer preference using 2 different drying methods.
Based on the results, it was found that visually the color produced by tatat leaves from the processing results was brighter with a brownish orange color, in contrast to tatat leaves which were brewed without processing which resulted in a pale yellow color. Based on the results of hedonic analysis, panelists prefer the taste, aroma, and color of tatat leaves from the processing treatment. The results of the analysis of phenol levels showed that the tatat leaves tea from the processing process was 91.078 mgGAE / g higher than the tatat leaves tea without processing 40.643 mgGAE / g. The results of the vitamin C test showed that the percentage of tatat leaves tea from the processing process was lower at 29.74 mg / 100 g compared to the tatat leaves from the direct drying method of 44.92 mg / 100 g.
DOUBLE MYSTIFICATION OF THE DRAHOMANOV SISTERS
Authors: Burlaka Halyna 
Published: August 2023

The subject of this research is the family correspondence of the Drahomanovs, a significant part of which remains unpublished. These archival materials have been prepared for publication in the upcoming issue of the annual journal “Heritage: Literary Source Studies. Textology”. They significantly enrich our knowledge of Mykhailo Drahomanov’s life and his circle, while also presenting some complex tasks for the commentator. In particular, the letters of M. Drahomanov’s youngest brother, Oleksandr, mention his daughters Oksana and Nina. The dates mentioned in these references contradict the commonly known information about their birth years. Therefore, there is a need to clarify their actual years of birth.
Oksana Drahomanova was a lawyer, a participant in Ukraine’s liberation struggle in 1918—1921, an international women’s movement activist, a writer, and a translator. Various mentions provide different birth dates for Oksana, most often 1894 but occasionally 1892. The information about Oksana and Nina Drahomanova that has been circulated in the scholarly literature is based mostly on the distant relatives’ and acquaintances’ memories, which are often unreliable in terms of dating. In addition, Oksana herself may have altered her passport data, ‘rejuvenating’ herself by at least three years during her emigration overseas. The present research incorporates modern sources and archival materials, including memories, photographs, correspondence, and other documents. A decisive piece of evidence was a photograph of little Oksana, about one and a half years old, with a gift inscription from her father, dated June 1892. Thus, it is proved that Oksana Drahomanova was actually born in early 1891, but the exact date has yet to be established.
Little is known about Nina Drahomanova, with her birth year commonly believed to be 1900 or 1901. However, based on the letters of her father Oleksandr from 1898—1912, it can confidently be stated that Nina was born in 1898.
In addition, through the study of sources, the exact birth date of Oleksandr Drahomanov is determined to be August 4, 1859, according to the old style.
The paper demonstrates how preparing texts for publication and scholarly commentary on archival materials (in this case, epistolary ones) lead to heuristic discoveries.
LESIA UKRAINKA’S SONNET POEM AS A DYNAMIC SYSTEM
Authors: Moisiienko Anatolii 
Published: August 2023

A sonnet poem, typically consisting of a thesis, an antithesis, and a conclusion, is a dynamic entity by its very nature. In the sonnets by Lesia Ukrainka, various aspects of such dynamics can be observed at both the proper textual and intertextual levels. At the textual level, an important role in the dynamization of the text system is primarily played by numerous lexical and syntactic repetitions. While tradition has long prevented the use of lexical repetitions in sonnet texts, the experience of outstanding masters, such as Lesia Ukrainka, proves that disregarding this tradition occurs due to the author’s creative approach to the issue.
The figurative and semantic dynamics of Lesia Ukrainka’s sonnets are often initiated with the very first word, which is further actualized through anaphoric and other repeated elements. In the first version of the “Fa” sonnet, the highly expressive dynamics of gradation in rhetorical interrogative sentences, introduced in the second quatrain, reach their intense paradigmatic expression in the tercet endings. To a large extent, a different character of the figurative and intonation course, corresponding to the meaningful intra-dialogical unfolding of the literary canvas, can be traced in the compositional system of the sonnet “The Last Song of Maria Stewart”, where the initial interrogative construction finds a logical continuation in the final lines of the exclamatory sentence.
The sonnet “Breath of the Desert”, the figurative dynamics of which are realized mostly due to the intertextual situation, shows still another character of the compositional course. Based on the perception of Lesia Ukrainka’s poem “Khamsin”, written, by the way, on the same day as the sonnet (both poems belong to the “Spring in Egypt” cycle), the image of the free and capricious wind (‘khamsin’) acquires a deep meaning. Intertextual and apperceptive dynamics can also be observed in the Bakhchysarai triptych from the cycle “Crimean Memories”, which undoubtedly alludes to Adam Mickiewicz’s “Crimean Sonnets”. However, the perception of the literary heritage here is highly individual: unlike Mickiewicz’s generally romantic interpretation of events, Lesia Ukrainka discusses the affairs of long-gone days in her sonnet from the standpoint of a narrator ‒ a contemporary of the new age, who interprets historical processes in relation to present realities.
Shaping The Meaning Through Simulation and Constructing Alternative Reality in Ian Mcewan’s Machines Like Me
Authors: AVCU İsmail 
Published: August 2023

Ian McEwan uses elements of science-fiction and puts forwards some vague issues about artificial intelligence in Machines Like Me, thus leaving the reader in a technologically advanced, sci-fi utopia dominated by hyperrealism, subjectivity, and consumerism, which later turns into a moral dystopia with discrepancies of humankind’s interaction with AI humanoid robots. He offers a retro-futuristic universe where notions such as morality, human nature, and free will are challenged in an environment generated by postmodern tactics of historiographic metafiction and intertextuality as well as simulation. McEwan also provides us with a postmodern picture of contemporary individuals and conditions in which thin lines between the intrusion of artificial intelligence into our lives and the representation of truth and reality are blurred.
Making use of theoretical concepts such as postmodern simulation, historicity, and production of knowledge under how McEwan presents the major subject matters in the novel with the reflection and depiction of a futuristic world of artificial intelligence, this article tries to answer the questions about the condition of the postmodern individual who struggles with the issues of discerning reality and truth haunted by the existence and intrusion of AI Adams and Eves.
Gut microbial change after administration of Lacticaseibacillus paracasei AO356 is associated with anti-obesity in a mouse model
Authors: Song Eun-Ji , Lee Eun-Sook , Kim Young In , Shin Dong-Uk , Eom Ji-Eun , Shin Hee Soon , Lee So-Young , Nam Young-Do 
Published: August 2023

IntroductionThe status of an impaired gut microbial community, known as dysbiosis, is associated with metabolic diseases such as obesity and insulin resistance. The use of probiotics has been considered an effective approach for the treatment and prevention of obesity and related gut microbial dysbiosis. The anti-obesity effect of Lacticaseibacillus paracasei AO356 was recently reported. However, the effect of L. paracasei AO356 on the gut microbiota has not yet been identified. This study aimed to elucidate the effect of L. paracasei AO356 on gut microbiota and ensure its safety for use as a probiotic.MethodsOral administration of L. paracasei AO356 (107 colony-forming units [CFU]/mg per day, 5 days a week, for 10 weeks) to mice fed a high-fat diet significantly suppressed weight gain and fat mass. We investigated the composition of gut microbiota and explored its association with obesity-related markers.ResultsOral administration of L. paracasei AO356 significantly changed the gut microbiota and modified the relative abundance of Lactobacillus, Bacteroides, and Oscillospira. Bacteroides and Oscillospira were significantly related to the lipid metabolism pathway and obesity-related markers. We also confirmed the safety of L. paracasei AO356 using antibiotics resistance, hemolysis activity, bile salt hydrolase activity, lactate production, and toxicity tests following the safety assessment guidelines of the Ministry of Food and Drug Safety (MFDS).DiscussionThis study demonstrated that L. paracasei AO356 is not only associated with an anti-obesity effect but also with changes in the gut microbiota and metabolic pathways related to obesity. Furthermore, the overall safety assessment seen in this study could increase the potential use of new probiotic materials with anti-obesity effects.
Acupuncture improves the emotion domain and lipid profiles in women with polycystic ovarian syndrome: a secondary analysis of a randomized clinical trial
Authors: Chang Hui , Shi Baichao , Ge Hang , Liu Chengdong , Wang Lirong , Ma Chengcheng , Liu Lifeng , Zhang Wanyu , Zhang Duojia , Wang Yong , Wang Chi Chiu , Wu Xiaoke 
Published: August 2023

ObjectiveThis study aims to evaluate the effect of acupuncture on the emotion domain and metabolic parameters of Chinese women with polycystic ovarian syndrome (PCOS) by secondary analysis of a randomized clinical trial, conducted from 6 July 2012 to 7 October 2015.MethodIn this study, we investigated the effects of acupuncture (458 patients) and sham acupuncture (468 patients) on metabolic parameters, serum ions, and all quality-of-life scale scores related to PCOS. The quality of life of patients was evaluated using five relevant scales, operated by the research assistant, namely, PCOSQ, SF-36, and ChiQOL, as well as Zung-SAS and Zung-SDS. Metabolic parameters and serum ions were measured.ResultsA reduction in acne score, AN, Hcy, and LDL-C, and an increase in the level of lipoprotein α, Apo A1, and Apo A1/Apo B were observed in the acupuncture group after 4 months’ intervention after adjusting clomiphene and reproductive outcome (p&lt; 0.05). An increase in SF-36 total scores, RP and RE scores, ChiQOL total scores, and emotion domain scores was observed in the acupuncture group after 4 months’ intervention, while PF and HT scores were decreased (adjusted p&lt; 0.05). Those same changes were observed in sham acupuncture. Meanwhile, the serum levels of Ca, K, and Cl were elevated in the acupuncture group after the interventions (adjusted p&lt; 0.005). There were no significant differences in HOMA-IR, MetS, FPG, FINS, HDL-C, TG, Apo B, and level of serum P, Mg, and Na. Also, no changes in BP, GH, VT, SF, physical form domain, and spirit domain were observed after treatment.ConclusionAcupuncture can improve not only the emotional changes in SF-36 scores and ChiQOL scores, but also lipid metabolism, implying that it may have a correlation between emotional change and lipid metabolism. Furthermore, acupuncture can also regulate the changes of serum Ca, K, and Cl.Clinical trial registrationClinicalTrials.gov, identifier NCT01573858.
Glial autoantibody prevalence in Chinese optic neuritis with onset after age 45: clinical factors for diagnosis
Authors: Song Honglu , Chuai Yucai , Yang Mo , Zhou Huanfen , Sun Mingming , Xu Quangang , Wei Shihui 
Published: August 2023

PurposeAs glial autoantibody testing is not yet available in some areas of the world, an alternative approach is to use clinical indicators to predict which subtypes of middle-aged and elderly-onset optic neuritis (ON) have manifested.MethodThis study was a single-center hospital-based retrospective cohort study. Middle-aged and elderly-onset ON patients (age &gt; 45 years) who had experienced the first episode of ON were included in this cohort. Single- and multi-parametric diagnostic factors for middle-aged and elderly-onset myelin oligodendrocyte glycoprotein immunoglobulin-associated ON (MOG-ON) and aquaporin-4 immunoglobulin-related ON (AQP4-ON) were calculated.ResultsFrom January 2016 to January 2020, there were 81 patients with middle-aged and elderly-onset ON, including 32 (39.5%) AQP4-ON cases, 19 (23.5%) MOG-ON cases, and 30 (37.0%) Seronegative-ON cases. Bilateral involvement (47.4%, P = 0.025) was most common in the MOG-ON group. The presence of other concomitant autoimmune antibodies (65.6%, P = 0.014) and prior neurological history (37.5%, P = 0.001) were more common in the AQP4-ON group. The MOG-ON group had the best follow-up best-corrected visual acuity (BCVA) (89.5% ≤ 1.0 LogMAR, P = 0.001). The most sensitive diagnostic factors for middle-aged and elderly-onset MOG-ON were ‘follow-up VA ≤ 0.1 logMAR’ (sensitivity 0.89), ‘bilateral involvement or follow-up VA ≤ 0.1 logMAR’ (sensitivity 0.95), ‘bilateral involvement or without neurological history’ (sensitivity 1.00), and ‘follow-up VA ≤ 0.1 logMAR or without neurological history’ (sensitivity 1.00), and the most specific factor was ‘bilateral involvement’ (specificity 0.81). The most sensitive diagnostic factors for middle-aged and elderly-onset AQP4-ON were ‘unilateral involvement’ (sensitivity 0.88), ‘unilateral involvement or neurological history’ (sensitivity 0.91), and ‘unilateral involvement or other autoimmune antibodies’ (sensitivity 1.00), and the most specific factor was neurological history (specificity 0.98).ConclusionBased on our cohort study of middle-aged and elderly-onset ON, MOG-ON is less prevalent than AQP4-ON and Seronegative-ON. Using multiple combined parameters improves the sensitivity and negative predictive value for diagnosing middle-aged and elderly-onset MOG-ON and AQP4-ON. These combined parameters can help physicians identify and treat middle-aged and elderly-onset ON early when glial autoantibody status is not available.
An integrative phenology and climatic suitability model for emerald ash borer
Authors: Barker Brittany S. , Coop Leonard , Duan Jian J. , Petrice Toby R. 
Published: August 2023

IntroductionDecision support models that predict both when and where to expect emerald ash borer (EAB), Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), are needed for the development and implementation of effective management strategies against this major invasive pest of ash (Fraxinus species) in North America and other regions such as Europe. We present a spatialized model of phenology and climatic suitability for EAB for use in the Degree-Days, Risk, and Phenological event mapping (DDRP) platform, which is an open-source decision support tool to help detect, monitor, and manage invasive threats.MethodsWe evaluated the model using presence records from three geographic regions (China, North America, and Europe) and a phenological dataset consisting primarily of observations from the northeastern and midwestern United States. To demonstrate the model, we produced phenological event maps for a recent year and tested for trends in EAB’s phenology and potential distribution over a recent 20-year period.ResultsOverall, the model exhibited strong performance. Presence was correctly estimated for over 99% of presence records and predicted dates of adult phenological events corresponded closely with observed dates, with a mean absolute error of ca. 7 days and low estimates of bias. Climate stresses were insufficient to exclude EAB from areas with native Fraxinus species in North America and Europe; however, extreme weather events, climate warming, and an inability for EAB to complete its life cycle may reduce suitability for some areas. Significant trends toward earlier adult emergence over 20 years occurred in only some areas.DiscussionNear real-time model forecasts for the conterminous United States are available at two websites to provide end-users with decision-support for surveillance and management of this invasive pest. Forecasts of adult emergence and egg hatch are particularly relevant for surveillance and for managing existing populations with pesticide treatments and parasitoid introductions.
Association between retinol binding protein-4 and psoriasis vulgaris: a systematic review and meta-analysis
Authors: Gao Guangcheng , Cui Yuli , Cheng Haiyan 
Published: August 2023

BackgroundPsoriasis vulgaris is a chronic skin disease which is related to cardiovascular and metabolic diseases. In the pathogenesis of these diseases, adipokines, including retinol binding protein-4 (RBP-4), play crucial roles. Studies have also shown that RBP-4 might be a meaningful factor in psoriasis however, relying on the analysis of a single study have some drawbacks.ObjectiveTo evaluate the association between RBP-4 and psoriasis vulgaris more comprehensively.MethodsSix databases were searched to obtain relevant publications. The selection of the included studies was based on a criteria. The standardized mean difference (SMD) was used for analysis. A value of p &lt; 0.05 was defined as significance.ResultsSeven studies were included, with 271 cases and 235 controls. In the comparison between patients and controls, the merged data suggested that levels of RBP-4 were significantly higher in patients (SMD = 0.61, 95%CI: 0.14, 1.07, p &lt; 0.05). In five studies containing the data of RBP-4 levels before and after treatment, no significance was found, either for RBP-4 levels in the after-treatment group and control group in these five studies (p &gt; 0.05). Subgroup analysis was conducted based on the therapy method. Patients with systematic treatment showed a significant decrease of BRP-4 level after the treatment (SMD = −0.64, 95%CI: −1.26, −0.03, p &lt; 0.05).ConclusionFor patients with psoriasis vulgaris, RBP-4 levels are elevated, and systematic treatment can lower these levels. RBP-4 might act as a key indicator for the diagnosis, efficacy assessment, and comorbidity monitoring of the patients. Further studies with well-designed protocols and enlarged populations are still needed.
Correlation analysis of endoscopic manifestations and eradication effect of Helicobacter pylori
Authors: Luo Xin , Li Hui , He Li 
Published: August 2023

BackgroundHelicobacter pylori (H. pylori) infection is the most important risk factor for gastric cancer. Eradication of H. pylori significantly reduces the incidence and mortality of gastric cancer. H. pylori resistance to antibiotics and a gradual decline in eradication rates are gaining more and more attention. Our study aimed to address the correlation between endoscopic manifestations and the eradication effect of H. pylori.MethodsWe retrospectively reviewed outpatients in our hospital with H. pylori infection undergoing eradication therapy from January 2022 to March 2023. Both the primary diagnosis and eradication of H. pylori after treatment were confirmed by a 13C urea breath test. Patients were treated with a proton pump inhibitor (PPI)-based quadruple therapy. Clinical characteristics and endoscopy manifestations within 7 days before or after patients were diagnosed with H. pylori infection were analyzed.ResultsFrom January 2022 to March 2023, a total of 323 patients were enrolled in this study. There were 138 male patients and 185 female patients. The mean age of patients was 45.62 ± 13.04 years. The H. pylori initial eradication rate was 82.0%. Univariate analysis of factors affecting H. pylori eradication showed that sex, age, and endoscopic manifestations including diffuse redness, multiple white, and flat elevated lesions, and atrophy were significantly associated with the failure of H. pylori eradication therapy. A multivariable logistic regression model analysis of these five factors showed that patients aged over 60 years with multiple white and flat elevated lesions in the endoscopic examination are significantly less likely to eradicate H. pylori with empirical quadruple therapy. On the other hand, patients with diffuse redness were significantly more likely to eradicate H. pylori infection with empirical quadruple therapy.ConclusionOur study shows that age over 60 years old, multiple white and flat elevated lesions in endoscopic examination are independent risk factors of initial H. pylori eradication failure with empirical quadruple therapy, while diffuse redness in endoscopic examination is a protective factor of initial H. pylori eradication failure with empirical quadruple therapy, while diffuse redness in endoscopic examination is a protective factor. For patients with these risk factors, a drug sensitivity test or H. pylori resistance gene mutation detection may be more appropriate. However, further mechanism studies or prospective studies are needed to prove our findings.