bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiomic profiles of bile in patients with benign and malignant pancreaticobiliary disease
Authors: Poudel Shyam K. , Padmanabhan Roshan , Dave Heloni , Guinta Kathryn , Stevens Tyler , Sanaka Madhusudhan R. , Chahal Prabhleen , Sohal Davendra P. S. , Khorana Alok A. , Eng Charis 
Published: April 2023

Background
The prognostic and pathophysiologic significance of the biliary microbiota in pancreaticobiliary malignancies is little understood. Our goal was to find malignancy-related microbiomic fingerprints in bile samples taken from patients with benign and malignant pancreaticobiliary diseases.

Methods
Bile specimens were collected from consenting patients during routine endoscopic retrograde cholangiopancreatography. We used PowerViral RNA/DNA Isolation kit to extract DNA from bile specimens. The Illumina 16S Metagenomic Sequencing Library Preparation guide was used to amplify the bacterial 16S rRNA gene and create libraries. QIIME (Quantitative Insights Into Microbial Ecology), Bioconductor phyloseq, microbiomeSeq, and mixMC packages were used for post-sequencing analysis.

Results
Of 46 enrolled patients, 32 patients had pancreatic cancers, 6 had cholangiocarcinoma and 1 had gallbladder cancer. Rest of the patients had benign diseases including gallstones, and acute and chronic pancreatitis. We used multivariate approach in mixMC to classify Operational Taxonomic Units (OTUs). Doing this, we found a predominance of genera Dickeya (p = 0.00008), [Eubacterium] hallii group (p = 0.0004), Bacteroides (p = 0.0006), Faecalibacterium (p = 0.006), Escherichia-Shigella (p = 0.008), and Ruminococcus 1 (p = 0.008) in bile samples from pancreaticobiliary cancers as compared to benign diseases. Additionally, bile samples from patients with pancreatic cancer exhibited a predominance of genus Rothia (p = 0.008) as compared to those with cholangiocarcinoma, whereas bile samples from patients with cholangiocarcinoma exhibited a predominance of genera Akkermansia (p = 0.031) and Achromobacter (p = 0.031) as compared to those with pancreatic cancers.

Conclusions
Both benign and malignant pancreaticobiliary diseases have distinct microbiomic fingerprints. The relative abundance of OTUs in bile samples varies between patients with benign and malignant pancreaticobiliary diseases, as well as between cholangiocarcinoma and pancreatic cancer. Our data suggest that either these OTUs play a role in carcinogenesis or that benign disease-specific microenvironmental changes differ from cancer-specific microenvironmental changes, resulting to a clear separation of OTU clusters. We need more research to confirm and expand on our findings.
Assessing pharmacists and other healthcare providers’ knowledge of hand sanitization during COVID-19 pandemic in Jordan: A comparative study
Authors: Darwish Rula M. , AlMasri Mohammad , Ammar Khawla , AlMasri Rama , Al- Najar Hani , Al-Masri Mahmoud M. 
Published: April 2023

BackgroundHealth care providers including pharmacists are often on the first line when dealing with COVID -19; they can be under threat of contracting and spreading the disease. We aimed to assess and compare their knowledge of hand sanitization during COVID-19 pandemic to improve quality of care.MethodsA cross-sectional study was conducted in Jordan, on healthcare providers in different settings from 27 October till 3 December 2020, using a pre-validated electronic questionnaire. Participants (n = 523) were healthcare providers practicing in different settings. Descriptive and association statistical analyses were produced on the data using SPSS 26. Chi square was used for the categorical variables, and One way ANOVA was used on the continuous and categorical variables.ResultsA significant difference was recorded in total knowledge mean according to gender (59.78 vs 61.79 p = 0.030) in favor of men, and between pharmacists and other healthcare providers in favor of the latter (59.22 vs 61.45, p = 0.02). No significant difference was generally noticed between those who attended hand hygiene training and those who did not.ConclusionHealthcare providers’ knowledge of hand hygiene was generally good among participants, regardless of training and it was possibly increased because of fear of COVID-19 infection. Physicians were the most knowledgeable in regard of hand hygiene while pharmacists were the least among healthcare providers. Thus, structured, more frequent, and tailored training on hand sanitization in addition to new educational strategies are recommended for healthcare providers, in particular, pharmacists for better quality of care especially in pandemics.
Acute pain and analgesic requirement after vaginal childbirth with and without neuraxial labor analgesia–Retrospective cohort study
Authors: Maeda Ayumi , Shimada Gen , Fujita Nobuko , Suzuki Rimu , Yamanaka Michiko , Takahashi Osamu , Uchida Tokujiro , Nagasaka Yasuko 
Published: April 2023

Background
Few data are available on the intensity of pain that women experience during the first five days after vaginal childbirth. Moreover, it is unknown if the use of neuraxial labor analgesia has any impact on the level of postpartum pain.

Methods
We performed a retrospective cohort study based on chart review of all women who delivered vaginally at an urban teaching hospital between April 2017 and April 2019. The primary outcome was the area under the curve of pain score on numeric rating scale (NRS) documented in electronic medical records for five days postpartum (NRS-AUC5days). Secondary outcomes included peak NRS score, doses of oral and intravenous analgesics consumed during the first five days postpartum, and relevant obstetric outcomes. Logistic regression was used to examine the associations between the use of neuraxial labor analgesia and pain-related outcomes adjusting for potential confounders.

Results
During the study period, 778 women (38.6%) underwent vaginal delivery with neuraxial analgesia and 1240 women (61.4%) delivered without neuraxial analgesia. Median (Interquartile range) of NRS-AUC5days was 0.17 (0.12–0.24) among women who received neuraxial analgesia and 0.13 (0.08–0.19) among women who did not (p<0.001). Women who received neuraxial analgesia were more likely to require the first- and second-line analgesics postpartum than women who did not: diclofenac (87.9% vs. 73.0%, p< 0.001, respectively); acetaminophen (40.7% vs. 21.0%, p< 0.001, respectively). The use of neuraxial labor analgesia was independently associated with increased odds of having NRS-AUC5days in the highest 20 percentile (adjusted odds ratio [aOR] 2.03; 95% confidence interval [CI] 1.55–2.65), having peak NRS ≥ 4 (aOR 1.54; 95% CI 1.25–1.91) and developing hemorrhoids during the postpartum hospitalization (aOR 2.13; 95% CI 1.41–3.21) after adjusting for relevant confounders.

Conclusion
Although women who used neuraxial labor analgesia had slightly higher pain scores and increased analgesic requirement during postpartum hospitalization, pain after vaginal childbirth was overall mild. The small elevation in the pain burden in neuraxial group does not seem to be clinically relevant and should not influence women’s choice to receive labor analgesia.
Hepatic Amyloidosis With Multiorgan Involvement
Authors: Duve Robert J. , Moga Tiberiu G. , Yang Kevin , Mahl Thomas C. , Dove Eric 
Published: April 2023

ABSTRACT
Amyloidosis is a diverse entity that poses both diagnostic and treatment challenges. Whether systemic or local, amyloidosis has varied manifestations including occasional hepatic involvement. Hepatic amyloidosis, although rare, should be on the differential for those with unexplained hepatomegaly, cholestasis, alkaline phosphatase elevations, other associated organomegaly, and those with certain epidemiologic risks. In this study, we report a case of a man with systemic amyloid light chain amyloidosis with multiorgan involvement, acute liver injury, cholestasis, nephrotic syndrome, cardiomegaly, and bleeding diathesis.
Postinfantile Giant Cell Hepatitis Secondary to Rheumatoid Arthritis
Authors: Martinez-Moad Miranda , Wunderlich Grant , Diep Darlene , Vasudevan Akshay , Russell Alison , Janitz Tyler , Aluri Bineetha , Oviedo Angelica , Mysore Rangaraju Ayyappa 
Published: April 2023

ABSTRACT
Postinfantile giant cell hepatitis (PIGCH), also known as syncytial giant cell hepatitis, continues to be a poorly defined and rare disease presentation in the adult population. Although a common finding in neonates, there is limited literature on the disease process, causes, and treatment success of PIGCH in adults. A strong association between autoimmune disorders and PIGCH, considerably so in the case of autoimmune hepatitis, has been established. However, there have been limited to no reports of PIGCH secondary to rheumatoid arthritis. Our clinical case aims to bring forth a vignette of PIGCH to spotlight this ill-defined disease in the adult population and highlight some of the proposed causes, treatments, and laboratory markers.
The spinorial energy for asymptotically Euclidean Ricci flow
Authors: Baldauf Julius , Ozuch Tristan 
Published: April 2023

Abstract
This article introduces a functional generalizing Perelman’s weighted Hilbert-Einstein action and the Dirichlet energy for spinors. It is well defined on a wide class of noncompact manifolds; on asymptotically Euclidean manifolds, the functional is shown to admit a unique critical point, which is necessarily of min-max type, and the Ricci flow is its gradient flow. The proof is based on variational formulas for weighted spinorial functionals, valid on all spin manifolds with boundary.
Monitor of the single event upsets and linear energy transfer of space radiation on the Beidou navigation satellites
Authors: Zhang Binquan , Zhang Shenyi , Shen Guohong , Tuo Changsheng , Zhang Xin , Zhang Huanxin , Quan Lin , Tian Chao , Hou Donghui , Zhou Ping , Ji Wentao 
Published: April 2023

Abstract
The single event effect caused by space heavy ion radiation is one of the important factors affecting the safety and operation of spacecraft on orbit. In the research and evaluation of the frequency, spatial distribution and time characteristics of single event effects, linear energy transfer (LET) spectra of space radiation play an important role. On the Beidou navigation M15 and M16 satellites, a single event upset (SEU) and LET monitor was developed to obtain the upsets of the memory device and the LET spectra of space radiation which passes through the device. Through the measurement results from this monitor, the correlation between the device’s SEUs and the LET spectra could be studied.
Association of interleukin-10 rs1800896, rs1800872, and interleukin-6 rs1800795 polymorphisms with squamous cell carcinoma risk: A meta-analysis
Authors: Wei Zhenxia , Su Xiaoping , Hu Qiurui , Huang Yonghui , Li Cuiping , Huang Xuanping 
Published: April 2023

Abstract
The relationship between interleukin (IL)-10 and IL-6 gene polymorphisms and squamous cell carcinoma (SCC) has been demonstrated but with inconsistent conclusions. The aim of this study was to evaluate the potential associations of IL gene polymorphisms and the SCC risk. PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, China Biomedical Database, WanFang, and China Science and Technology Journal Database databases were searched for articles reporting the correlations of IL-10 and IL-6 gene polymorphisms with the SCC risk. Odds ratio and 95% confidence interval were calculated using Stata Version 11.2. Meta-regression, sensitivity, and publication bias were analyzed. False-positive reporting probability and Bayesian measure of the false-discovery probability were used to explore the credibility of the calculation. Twenty-three articles were included. The IL-10 rs1800872 polymorphism showed a significant correlation with the SCC risk in the overall analysis. Studies pooled by ethnicity revealed that the IL-10 rs1800872 polymorphism reduced the SCC risk in the Caucasian population. The results of this study suggest that the IL-10 rs1800872 polymorphism may confer a genetic susceptibility to SCC, particularly oral SCC, in Caucasians. However, the IL-10 rs1800896 or IL-6 rs1800795 polymorphism was not significantly associated with the SCC risk.
The Global Conversation on Sustainability
Authors: Vidal Juliana L. , Borges João 
Published: April 2023

Abstract
Since 25 September 2022, the International Younger Chemists Network (IYCN) and the International Union of Pure and Applied Chemistry (IUPAC) are jointly organizing the Global Conversation on Sustainability (GCS, https://www.gcs-day.org) in an annual fashion. This day has been chosen because it marks the anniversary of the United Nations Sustainable Development Goals (UN SDGs) [1].
Surfactant assisted single step electrodeposition of CuInSe2 thin films with rich indium selenide surface over layer
Authors: Singh Priti , Upadhyay Pundrikaksha , Chandran Ramkumar , Das Sanjeev , Mallik Archana 
Published: April 2023

Abstract
In this work, we report on the electrodeposition of CuInSe2 (CIS) thin films with In2Se3 rich surface by a single step deposition technique. It was observed that the In-content deposited in CIS can be improved by the addition of sodium dodecyl sulfate as a surfactant. The presence of an In–Se rich layer was confirmed by electrochemical, compositional and Raman spectroscopy analysis. The photo-electrochemical properties of the as-deposited CuInSe2 thin films were found to be enhanced due to the presence of In–Se rich superficial layer. The presence of an In–Se layer over CIS may act as a p-n homo-junction which may be attributed as the primary reason for the improvement in the PEC properties.
A detailed quasigeoid model of the Hong Kong territories computed by applying a finite-element method of solving the oblique derivative boundary-value problem
Authors: Čunderlík Robert , Tenzer Robert , Macák Marek , Zahorec Pavol , Papčo Juraj , Nsiah Ababio Albertini 
Published: April 2023

Abstract
New gravity and precise levelling measurements have been performed throughout the Hong Kong territories to modernize a vertical geodetic datum that is currently realized by heights of levelling benchmarks defined in the Hong Kong Principal Datum (HKPD). Modernization of the HKPD involved delivering various products, including new detailed geoid and quasigeoid models and newly determined orthometric and normal heights of levelling benchmarks. In this study, we present the result of gravimetric quasigeoid modelling. The method used to compute a detailed gravimetric quasigeoid model is based on the finite-element method to solve the geodetic boundary-value problem with oblique derivative boundary conditions considered directly at computational nodes on the discretized Earth’s topography. The result of a gravimetric quasigeoid modelling shows a good agreement with a geometric quasigeoid model at the Global Navigation Satellite System (GNSS)-levelling benchmarks. The standard deviation of differences between the gravimetric and geometric quasigeoid heights of ±3.3 cm is compatible with the expected accuracy of gravity, levelling, and GNSS measurements.
Executive function, behavioral problems, and insulin resistance in adolescents with obesity
Authors: Gundogdu Ummugulsum , Gurer Guliz , Eroglu Mehtap 
Published: April 2023

Abstract

Objectives
In this study, we examined executive function (EF) abilities, behavioral and emotional (BE) issues, and overall quality of life (QoL) of adolescents with obesity and compared them with a control group and also aimed to investigate whether the presence of insulin resistance (IR) is associated with these problems.

Methods
This cross-sectional study included a sample of 50 adolescents aged 11–18 years with obesity and age- and gender-matched 50 normal weight adolescents who had attended and were treated at the pediatric outpatient clinic. Sociodemographic data were collected through personal interviews with the adolescents and their parents. Measurements of the height and weight, fasting blood glucose, and insulin levels of all adolescents were assessed. In addition, the participants and their parents completed the Kiddo-KINDL, the Strengths and Difficulties Questionnaire, and the Behavior Rating Inventory Scale from Executive Function.

Results
Of the 50 adolescents with obesity, 27 (54.0 %) were girls, and 23 (46.0 %) were boys, with a mean age of 14.06 ± 1.83 years. Adolescents with obesity have more EF deficiencies, BE difficulties, more problems in peer relationships and lower QoL scores than those without obesity. The QoL was worse in girls, adolescents with obesity, and those with IR. Adolescents with obesity and those with and without IR did not differ about EF deficiencies and BE problems.

Conclusions
Addressing these EF deficits and BE problems in interventions for adolescents who have difficulty adapting to lifestyle changes, an essential part of obesity treatment in clinical practice, may contribute to treatment success.
Adolescents who practice physical activity have adequate food choices, regardless of the level of somatic maturation and adiposity
Authors: Tozo Tatiana Aparecida Affornali , Pereira Beatriz Oliveira , Brand Caroline , Tadiotto Maiara Cristina , Moreira Carla Marisa Maia , Leite Neiva 
Published: April 2023

Abstract

Objectives
Regular physical activity and adequate food are part of a healthy lifestyle for the maintenance of physical and metabolic health. To verify the moderating role of physical activity (PA) in the relationship between dietary patterns and body adiposity in adolescents, according to somatic maturation.

Methods
Study with cross-sectional design, sample of 336 adolescents of both sexes, aged between 11 and 17 years. Body mass, height, and waist circumference (WC) were evaluated. Body mass index (BMI), BMI z-score (BMI-z), waist-to-height ratio (WHtR), and somatic maturation by peak height velocity (PHV) were calculated. The level of PA was measured by the International Physical Activity Questionnaire and dietary pattern by the Food Frequency Questionnaire ELSA – Brazil (short version). Moderation analyzes were tested using multiple linear regression models, by PROCESS macro for SPSS.

Results
An inverse interaction of PA was observed in the relationship between food consumption factor 5 (ultra-processed foods category) and WC in boys categorized as pre-pubertal and pubertal PHV (β=−5.344; CI95 % −10.108 −0.580; p=0.028). For girls, no interaction was observed in any of the models analyzed.

Conclusions
It was observed that the level of PA can influence food choices in prepubertal and pubertal boys, since the active boys showed better dietary pattern and lower central adiposity. Therefore, the findings reinforce the need to encourage the regular practice of physical activities from an early age, mainly aimed at preventing obesity in children and adolescents.
Zur (Un-)Verständlichkeit der Rechtssprache am Beispiel der deutschen Rechtssprache
Authors: Bielawski Paweł 
Published: April 2023

Abstract
This paper investigates whether the criticisms of legal texts’ incomprehensibility are valid and justifiable. It therefore starts with determining the features of legal languages that are potentially responsible for jeopardizing the comprehensibility of legal texts. Next, it discusses the purposes (functions) these features serve in legal communication. By indicating a number of similarities between the legal and the everyday communication, the paper attempts to refute the criticisms of incomprehensibility in legal texts.
Melting rheology in thermally stratified graphene-mineral oil reservoir (third-grade nanofluid) with slip condition
Authors: Raizah Zehba , Rehman Sadique , Saeed Anwar , Akbar Mohammad , Eldin Sayed M. , Galal Ahmed M. 
Published: April 2023

Abstract
More effective and lengthy energy storage systems have been highly desired by researchers. Waste heat recovery, renewable energy, and combined heating and power reactors all utilize energy storage technologies. There are three techniques that are more effective for storing thermal energy: Latent heat storage is one type of energy storage, along with sensible heat storage and chemical heat storage. Latent thermal energy storage is far more efficient and affordable with these methods. A method of storing heat energy in a substance is melting. The substance is frozen to release the heat energy it had been storing. A ground-based pump’s heat exchanger coils around the soil freezing, tundra melting, magma solidification, and semiconducting processes are examples of melting phenomenon. Due to the above importance, the present study scrutinizes the behavior of third-grade nanofluid in a stagnation point deformed by the Riga plate. The Riga plate, an electromagnetic actuator, is made up of alternating electrodes and a permanent magnet that is positioned on a flat surface. Graphene nanoparticles are put in the base fluid (Mineral oil) to make a homogenous mixture. Mathematical modeling is acquired in the presence of melting phenomenon, quadratic stratification, viscous dissipation, and slippage velocity. Suitable transformations are utilized to get the highly non-linear system of ODEs. The remedy of temperature and velocity is acquired via the homotopic approach. Graphical sketches of various pertinent parameters are obtained through Mathematica software. The range of various pertinent parameters is

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Unclearing the Air: The Pneumatological Dalliances of Jacques Derrida
Authors: McCormack Ryan 
Published: April 2023

Abstract
In the 1980s, Luce Irigaray accused Western philosophy of “forgetting” about the role that the materiality of air and the act of breathing played in pre-Socratic metaphysics. This essay explores how Jacques Derrida maintained a complicated but insightful relationship to the air throughout his career through the mediating influence of pneuma, a word with long and complicated connections to the air. I highlight two relevant sites of engagement. The first was found in Of Grammatology (1968), where he connected the breathy logocentrism of “natural writing” to a concept of pneumatology (a “science of spirit” with some interesting connections to Leibniz) that served as grammatology’s Janus face. The second stemmed from Of Spirit (1991), in which Derrida emphasized the combustible, fiery face of pneuma to lambast Heidegger’s use of translation to mediate away the historical presence of the word pneuma for ideological purposes. This body of work, en toto, presents a subtle and oblique critique of Irigaray’s position. For Derrida, the air cannot function as the medium for an alternative metaphysics of presence because, historically, its space has already been infused with a pneumatic specter that cannot be ignored.