bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of Dexmedetomidine on suppression of the Bispectral Index Score and hemodynamic response during laryngoscopy and intubation in addicted patients in supratentorial brain tumor surgery
Authors: Asgari Sogol , Behnaz Faranak , Ommi Davood , Zandpazandi Sara 
Published: March 2023

Abstract
Background
Dexmedetomidine is an α2-adrenoceptor agonist that has good sedative effects with no cardiovascular instability or respiratory depression, and it might help facilitate endotracheal resection and inhibit hemodynamic responses. This study's objective was to assess how intravenous Dexmedetomidine affected cardiovascular response and endotracheal intubation in opium-addict patients.
Materials and Methods
This study is a clinically randomized double-blind controlled trial. 100 patient with a diagnosis of supratentorial brain tumor undergoing tumor resection surgery with general anesthesia entered this study. One group received Dexmedetomidine (1 /µg / kg for 10 minutes) before induction of anesthesia. The same amount of normal saline (placebo) was administered in the second group. the two groups were analyzed statistically regarding BP, HR, and BIS, which were recorded before induction of anesthesia, one minute after induction of anesthesia, and one minute after intubation. The statistical tests used for analysis are the student T-test, Mann-Whitney non-parametric test, the chi-Square test, and Fisher's exact test.
Results
Heart Rate, Systolic blood pressure, and Bispectral Index scores in the intervention group decreased one minute after anesthesia induction and after intubation compared to the control group. Diastolic Blood Pressure after induction of anesthesia was not significantly different between the two groups, however, it decreased following the intervention after intubation (p > 0.05).
Conclusion
Dexmedetomidine suppressed hemodynamic response and BIS score in opium-addict patients compared to the control group.
Art and fossils: the illustrators of Lucas Mallada’s paleontological Synopsis (1875-1892)
Authors: Rábano Isabel 
Published: March 2023

The Commission for the Geological Map of Spain planned a monumental work in the 19 th century, the “Synopsis of the fossil species found in Spain”, in which descriptions of the characteristic fossils of geological periods had to be combined with their illustrations in a paleontographical atlas. The objective was to constitute an auxiliary tool for those people who, without reference books at their reach, could determine in a practical way the Spanish geological formations. This work, which was to be published over several years, was entrusted to the mining engineer Lucas Mallada y Pueyo. The fossil drawings were handled by three artists: Teresa Madasú, José Cebrián and Fernando de los Villares Amor. The work was never completed, but between 1875 and 1892 250 plates of Cambrian to Paleogene fossils were published, most of them (206) drawn by Teresa Madasú, who therefore stands as the pioneer of paleontological illustration in Spain.
Knockdown of Programmed Death 1 Inhibited Progression of Papillary
Thyroid Carcinoma in Mice
Authors: Wang Hui , Chu Qianqian , Ma Shihong , Tao Ying 
Published: March 2023

Background:
PD-L1 and PD1 mainly focused on melanoma, lung cancer and other tumors,
while the related studies on early lymph node metastasis of papillary thyroid carcinoma were rarely
reported.

Objective:
For elucidating the role of programmed death 1 (PD1)/programmed death ligand 1 (PD-L1)
pathway in tumor growth of papillary thyroid carcinoma (PTC).

Methods:
Human thyroid cancer cell line and human normal thyroid cell line were obtained and
transfected with si-PD1 or pCMV3-PD1 for the construction of PD1 knockdown or overexpression
models. BALB/c mice were purchased for in vivo studies. Nivolumab was implemented for in vivo
inhibition of PD1. Western blotting was performed for determining protein expression, while RTqPCR
was used to measure relative mRNA levels.

Results:
The PD1 and PD-L1 levels were both significantly upregulated in PTC mice, while the
knockdown of PD1 downregulated both PD1 and PD-L1 levels. Protein expression of VEGF and FGF2
was increased in PTC mice, while si-PD1 decreased their expression. Silencing of PD1 using si-PD1
and nivolumab both inhibited tumor growth in PTC mice.

Conclusion:
Suppressing PD1/PD-L1 pathway significantly contributed to the tumor regression of
PTC in mice.
Integration of LC-LTQ-Orbitrap-MS and Network Pharmacology to Analyze
the Active Components of Sijunzi Decoction and their Mechanism of
Action Against Cytotoxicity-associated Premature Ovarian Insufficiency
Authors: Chen Yiying , Han Sixuan , Kang An , Fu Rui , Chen Li , Guo Jinrui , Wang Qiong 
Published: March 2023

Introduction:
Sijunzi Decoction (SJZD) is a classical prescription in traditional Chinese
medicine that enhances neuroimmune endocrine function to alleviate inflammatory aging, a key
pathogenic mechanism underlying premature ovarian insufficiency (POI). However, the mechanism
through which SJZD alleviates POI remains unknown. Hence, we aimed to identify the active
components of SJZD and its mechanism of therapeutic action against POI.

Methods:
We identified compounds in SJZD using liquid chromatography-linear trap quadrupole-
Orbitrap-mass spectrometry (LC-LTQ-Orbitrap-MS). Traditional Chinese Medicine Systems
(TCMSP) and HERB databases were used to identify the ingredients and potential targets of SJZD.
We analyzed Gene Ontology (GO) terms and enriched Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathways using RStudio and constructed a visual network using Cytoscape3.9.1.

Results:
We identified 98 compounds using LC-LTQ-Orbitrap-MS, among which 29 were bioactive.
The screen outputted yielded 151 predicted targets of these compounds that were associated
with POI. The results of the GO and KEGG analyses showed that these compounds play key roles
in cell growth, division, migration, and survival signaling pathways. Therefore, phosphatidylinositol
3-kinase (PI3K)/AKT, mitogen-activated protein kinase (MAPK), and epidermal growth factor
receptor (EGFR) pathways might be closely associated with the pharmacological effects of SJZD
on the pathological processes of POI.

Conclusion:
Our findings provide a scientific basis for rapidly analyzing bioactive compounds in
SJZD and their pharmacological mechanisms.
High-Throughput Screening for the Potential Inhibitors of SARS-CoV-2
with Essential Dynamic Behavior
Authors: Yang Zhiwei , Zhang Lei , Cai Xinhui , Ye Qiushi , Zhao Yizhen , Li Xuhua , Zhang Shengli 
Published: March 2023

Abstract:
Global health security has been challenged by the Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) pandemic. Due to the lengthy process of generating vaccinations, it
is vital to reposition currently available drugs in order to relieve anti-epidemic tensions and accelerate
the development of therapies for Coronavirus Disease 2019 (COVID-19), the public threat
caused by SARS-CoV-2. High throughput screening techniques have established their roles in the
evaluation of already available medications and the search for novel potential agents with desirable
chemical space and more cost-effectiveness. Here, we present the architectural aspects of highthroughput
screening for SARS-CoV-2 inhibitors, especially three generations of virtual screening
methodologies with structural dynamics: ligand-based screening, receptor-based screening, and machine
learning (ML)-based scoring functions (SFs). By outlining the benefits and drawbacks, we
hope that researchers will be motivated to adopt these methods in the development of novel anti-
SARS-CoV-2 agents.
Ferrocene Derivatives as New Generation of Antimalarial Agents: Opportunity
or Illusion?
Authors: Mangawa Shrawan Kumar , Singh Shailja 
Published: March 2023

Abstract:
Despite significant scientific progress over the last two decades, malaria remains a global burden that causes thousands of deaths every year. In the absence of effective and practical preven-tive measures, the only current option for reducing the mortality and morbidity of malaria is chemo-therapy. However, due to the minimal stock of active antiparasitic analogs, issues of toxicity, and the repeated appearance of drug resistance, scientists must broaden the arsenal of existing therapies beyond conventional medicinal chemistry. To curb this menace, a series of potential metal-based hybrids have been synthesized and screened. Ferrocene is one of the potent organometallic candi-dates and the hybridization of ferrocene with other pharmacophores results in compounds with en-hanced biological activities. Many researchers have reported the ferrocene compounds as potent pharmacophores and useful as anticancer and antimalarial agents when hybridized with other phar-maceutical hybrids. Drug, such as Ferroquine (FQ, SSR97193), is currently the most advanced or-ganometallic compound developed from the hybridization of ferrocene and chloroquine and has demonstrated great potency in clinical trials against both drug-sensitive and drug-resistant malaria. Not only ferroquine but its derivatives have shown significant activity as antimalarial agents. The present review focuses on the discovery of FQ, the hypothesis of its mode of action, and recent clin-ical trials of ferrocene compounds as a new class of antimalarial agents. The structure-activity rela-tionship (SAR) of ferrocene derivatives is also discussed to provide insight into the rational design of more effective antimalarial candidates. Finally, efforts have been made to discuss the future ex-pectations for ferrocene-based antimalarial drugs.
The Impact of Altered HCN1 Expression on Brain Function and Its Relationship
with Epileptogenesis
Authors: Zhao Ke , Li Yinchao , Yang Xiaofeng , Zhou Liemin 
Published: March 2023

Abstract:
Hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) is predominantly
expressed in neurons from the neocortex and hippocampus, two important regions related to epilepsy.
Both animal models for epilepsy and epileptic patients show decreased HCN1 expression and
HCN1-mediated Ih current. It has been shown in neuroelectrophysiological experiments that a decreased
Ih current can increase neuronal excitability. However, some studies have shown that blocking
the Ih current in vivo can exert antiepileptic effects. This paradox raises an important question regarding
the causal relationship between HCN1 alteration and epileptogenesis, which to date has not been
elucidated. In this review, we summarize the literature related to HCN1 and epilepsy, aiming to find a
possible explanation for this paradox, and explore the correlation between HCN1 and the mechanism
of epileptogenesis. We analyze the alterations in the expression and distribution of HCN1 and the corresponding
impact on brain function in epilepsy. In addition, we also discuss the effect of blocking Ih
on epilepsy symptoms. Addressing these issues will help to inspire new strategies to explore the relationship
between HCN1 and epileptogenesis, and ultimately promote the development of new targets
for epilepsy therapy.
Recent Advancements in Indole Derivatives and their Antimicrobial Perspective
Authors: Kumar Arvind , Kumari Deepika , Singh Harpreet , Mishra Amrita , Mishra Arun K. 
Published: March 2023

:Indole is an important heterocyclic molecule having a number of pharmacologically useful properties. Adolf von Baeyer synthesized indole by reducing oxindole in the presence of a catalytic amount of zinc dust in 1866. A number of studies have been conducted and many more are in the pipeline to investigate the medicinal potential of indole and its derivatives. Indomethacin, Indolmycin, Oxypertine, Yohimbine, Pindolol, and Delavirdine are indole containing drugs that are in high demand in the market.:The present study aims to highlight the indole nucleus containing drugs developed by researchers over the last 25 years, with a focus on antibacterial and antifungal properties present in these drugs. The mode of action and Structure–Activity Relationship (SAR) of indole derivatives, which are responsible for antibacterial and other relevant actions, are also highlighted in the present review. To aid scientists in exploring future potential in this domain, the present study includes the key qualities and highlights of each research activity done by researchers especially related to synthetic derivatives of Indoles.:All the available information on Indole derivatives was collected via electronic search (using Pubmed, SciFinder, Scirus, Google Scholar, and Web of Science) and the resources available in Central Library, IFTM University, Moradabad were also referred. The present review is based on literature collected and studied over the previous 23 years.:This article will aid researchers in the development of new molecules with indole derivatives undoubtedly which must have improved antibacterial and other properties.
Recent Advances in the Development of RET Inhibitors
Authors: Lu Peng , Qin Hui , Ye Jiawei , Chen Puzhou , Li Jiuxiang , Ren Jing , Wang Yan , Zhang Yinsheng 
Published: March 2023

Background:
Rearranged during transfection (RET) is a receptor tyrosine kinase and a bona
fide oncogene that drives various cancers. Oncogenic RET induces abnormal activation of RET kinase,
causing tumorigenesis. RET can be abnormally activated through RET point mutations and RET fusions.
Although RET kinase has been discovered in tumors more than 30 years ago, patients with RET-altered
tumors gain limited benefits from multikinase inhibitors (MKIs). In 2020, pralsetinib and selpercatinib
were approved by FDA for the treatment of RET-altered tumors.

Objective:
Recently reported RET inhibitors were reviewed to provide an overview of the development of
novel RET inhibitors.

Methods:
Literatures, patents, and conference proceedings published in the past five years were collected.
Only RET inhibitors with novel scaffolds or in vivo efficacy were discussed in this review. The enzymebased
and cell-based activities, PK profiles, antitumor activities in vivo, and clinical efficacy of the selected
RET inhibitors were described.

Results:
Great efforts have been spent on the development of RET inhibitors, leading to increased RETtargeted
therapies. Due to high potency and specificity, pralsetinib and selpercatinib resulted in a >8-
month improvement in overall survival, compared to MKIs. However, solvent-front mutants emerged and
contributed to the acquired resistance to pralsetinib and selpercatinib. To overcome solvent front mutants,
TPX-0046, TAS0953, and LOX-260 are investigated in early clinical studies.

Conclusion:
Zeteletinib, SYHA1815, TPX-0046, TAS0953, and LOX-260 are potential therapies for
RET-altered cancers. In addition, macrocyclic inhibitors, allosteric inhibitors, and PROTACs are three
promising strategies to address the potential drug resistance of RET.
Overview of the Current Advancements and Trends in the Transungual
Drug Delivery System
Authors: Sharma Kajol , Yadav Vivek , Reang Jurnal , Sharma Kalicharan , Tonk Rajiv Kumar , Jain Priti , Verma Surajpal 
Published: March 2023

Background:
Drug delivery across human nails is termed a transungual drug delivery system.
It is recommended for the amelioration of nail disorders and infectious nail diseases like onychomycosis.
Thereby, vivid anti-fungal regimens have been prescribed in the form of different types of formulations,
including nail lacquers, nail film, nail paint, and other types for treating onychomycosis.

Method:
All the formulations currently marketed or being marketed for the transungal drug delivery
system were thoroughly studied, compared, and evaluated for their advantages and disadvantages so that a
new vision can be sustained along the path of creating newer anti-fungal transunguals, keeping in mind
the anatomy of the nail and various parameters that govern bioavailability of active pharmaceutical ingredients
across the nail bed. Accordingly, different techniques are devised to enhance permeation across the
nail. The various parameters used to evaluate these formulations depend upon their physical, chemical,
and mechanical properties.

Conclusion:
The recent approaches in transungual novel drug delivery systems have been reported while
exemplifying a few patented and marketed formulations, along with the clinical trial status of these formulations.
There is a need for the development of new techniques to overcome all the loopholes present
in the ongoing treatment techniques and the formulations used nowadays for the treatments of diseases
that occur in nails. After thoroughly detailing transungal novel drug delivery systems, we envisage great
opportunities for the researchers to carry out novel work in chemotherapy through nails.
A Review of Functional Composite Materials using PSZ-based Siliconnitride
Preceramic Polymer
Authors: Xue Jing , Zhang Lijuan , Hou Yongzhao , Wang Dong , Li Ling , Wen Guangwu , Wang Jing 
Published: March 2023

Abstract:
The silicon-nitride ceramics gain a lot of interest for applications under severe conditions
due to their thermal stability, thermal shock resistance and chemical stability arising from the threedimensional
lattice structure. The silicon-nitride ceramics can be synthesized from silicon-nitride
preceramic polymers based on polysilazane (PSZ), as the ability to fabricate ceramic components of
specific geometries is difficult to obtain otherwise. This review systematically summarized the applications
of PSZ-based silicon-nitride preceramic polymers in the processing of functional materials. A
particular focus is made on the relation between the chemical structure of polymer and the properties
of the polymer-derived ceramic. The tailored properties as well as characteristics of ceramic are highlighted
and the trend of nowadays research for the future evolution of silicon-nitride preceramic polymer
was proposed.
Endometrial Cancer Stem Cells Related Signaling Pathways
Authors: Pour Fatemeh Khojasteh , Keivan Mona , Ghaedrahmati Farhoodeh , Saadati Najmieh , Moramezi Farideh , Nikbakht Roshan , Farzaneh Maryam 
Published: March 2023

Abstract:
Endometrial cancer is gynecologic cancer that occurs in the uterus. Endometrial cancer
stem cells (ECSC) are a small population of cancer cells that represent a crucial role in the metastasis
of endometrial cancer cells to other organs in the body. ECSC can proliferate and give rise to mature
cancer cells, which are found to participate in the aggressiveness of metastatic lesions. Therefore,
targeting ECSC can be a valuable strategy for drug development against the metastasis of endometrial
cancer. Previous studies have demonstrated that several signaling pathways, including Wnt,
mTOR, EGFR, NOTCH, STAT3, VEGF, and SHH show modest effects and regulate the growth,
epithelial-to-mesenchymal transition (EMT), and tumorigenesis of ECSC. Non-coding RNAs
(ncRNAs) also play an important role in ECSC self-renewal, progression, and drug resistance.
Hence, targeting these pathways might be a novel therapeutic approach for endometrial cancer diagnosis
and therapy. This mini-review aims to characterize the main signaling pathways involved in the
stimulation of ECSCs proliferation and tumorigenesis.
Ovarian Torsion and Oophorectomy in Childhood: A Case Report
Authors: Shabani Fatemeh , Montazeri Maryam , Shiva Siamak , Mirghafourvand Mojgan 
Published: March 2023

Background:
Ovarian torsion in infants can be asymptomatic or may present with ab-
dominal mass and malnutrition. It is an uncommon and non-specific condition in children. We re-
port a girl who underwent detorsion and ovariopexy for suspected ovarian torsion after a previous
oophorectomy. The role of progesterone therapy is determined in reducing the size of adnexal mass.

Case Presentation:
The patient was diagnosed with right ovarian torsion and underwent an oopho-
rectomy at one year of age. About 18 months later, she was diagnosed with left ovarian torsion and
underwent detorsion with lateral pelvic fixation. Despite the pelvic fixation of the ovary, a continu-
ous increase in the volume of the ovarian tissue was evident during successive ultrasounds. Proges-
terone therapy was started at five years of age in order to prevent retorsion and preserve the ovarian
tissue. In successive follow-ups during the therapy, ovarian volume decreased, and its size (27*18
mm) was restored.

Conclusion:
The presented case reminds doctors of the possibility of ovarian torsion in young girls
with pelvic pain. More research is needed on the use of hormonal drugs, such as progesterone, in
similar cases.
Counting and Identifying Probiotics: From a Systematic Comparison of Three Common Methods to Proposing an Appropriate Method for Identification
Authors: Zamanpour Setayesh , Afshari Asma , Hashemi Mohammad , Zeinali Tayebeh 
Published: March 2023

Background:
The plate count technique had traditionally been used for the determination
of viability and counting of probiotic bacteria, which had obvious disadvantages. Efficient
tools to identify and count probiotics (alone or in combination) have evolved.

Objective:
This study aimed to compare two methods of counting and identifying probiotics such
as Real-time PCR and flow cytometry, with the culture method and suggest an inexpensive
method for the diagnosis of probiotics in dairy products.

Methods:
Electronic databases such as Scopus, PubMed, and Science Direct were systematically
searched, identified, screened, and reviewed from June 2001 to December 2022.

Results:
This study showed that each technology has its strengths, advantages, and disadvantages,
but the Real-time PCR method is more suitable than other methods and can identify
and count live cells of probiotics.

Conclusion:
In conclusion, it should be mentioned that due to the superiority of the Real-time
PCR method, we recommend the use of this molecular method, but for more assurance and comparison,
several methods can be used to count and correctly identify probiotic strains.
Investigating the Effect of Kangaroo Mother Care on Maternal-Infant
Attachment: A Systematic Review and Meta-Analysis Study
Authors: Karimi Fatemeh Zahra , Abdollahi Mahbubeh , Khadivzadeh Talat , Yas Atefeh 
Published: March 2023

Background:
Maternal-infant attachment is the first social relationship between mother and
baby that keeps the baby close to the mother. The conflicting results of the studies regarding the effect
of kangaroo mother care (KMC) on maternal-infant attachment show the necessity of conducting a
meta-analysis study.

Objective:
The study aimed to investigate the effects of KMC on mother-infant attachment through a
systematic review and meta-analysis of randomized controlled trials.

Methods:
Web of Science, PubMed, Scopus, Cochrane Library, EMBASE, ProQuest, SID, and
Iranmedex databases were searched to find clinical trial studies in English and Persian without a time
limit. The Cochrane checklist was used to check the bias of the articles. Data analysis was performed
using STATA. I2 index was used in order to assess the heterogeneity, and the funnel plot and the Egger
test were used in order to examine the publication bias. Standardized mean difference (SMD) and
random effects models were used to combine the studies and perform a meta-analysis.

Results:
In this study, 10 articles were selected for the systematic review and meta-analysis. The results
of the present meta-analysis based on the random model showed SMD as -1.33 (95% CI: (-2.12, -
0.54), P = 0.001), and there was observed a statistically significant relationship between the control
and intervention groups. So, the mother-infant attachment in the intervention group was higher than in
the control group.

Conclusion:
This study showed that KMC improves mother-infant attachment. The results of this
study can be applied to evidence-based decision-making by healthcare providers, and can also be suggested
as a method to develop mother-infant attachment.