bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental changes associated with drying climate are expected to affect functional groups of pro- and microeukaryotes differently in temporary saline waters
Authors: Márton Zsuzsanna , Szabó Beáta , Vad Csaba F. , Pálffy Károly , Horváth Zsófia 
Published: February 2023

AbstractTemporary ponds are among the most sensitive aquatic habitats to climate change. Their microbial communities have crucial roles in food webs and biogeochemical cycling, yet how their communities are assembled along environmental gradients is still understudied. This study aimed to reveal the environmental drivers of diversity (OTU-based richness, evenness, and phylogenetic diversity) and community composition from a network of saline temporary ponds, soda pans, in two consecutive spring seasons characterized by contrasting weather conditions. We used DNA-based molecular methods to investigate microbial community composition. We tested the effect of environmental variables on the diversity of prokaryotic (Bacteria, Cyanobacteria) and microeukaryotic functional groups (ciliates, heterotrophic flagellates and nanoflagellates, fungi, phytoplankton) within and across the years. Conductivity and the concentration of total suspended solids and phosphorus were the most important environmental variables affecting diversity patterns in all functional groups. Environmental conditions were harsher and they also had a stronger impact on community composition in the dry spring. Our results imply that these conditions, which are becoming more frequent with climate change, have a negative effect on microbial diversity in temporary saline ponds. This eventually might translate into community-level shifts across trophic groups with changing local conditions with implications for ecosystem functioning.
Study on mechanical properties and energy change of rock materials in whole splitting process based on peridynamics
Authors: Li Hewan , Liu Jian , Wang Laigui , Ren Tianjiao 
Published: February 2023

AbstractAiming to bypass the inability to directly observe the evolution process of rock internal deformation and fracture, this paper proposes that rock samples with different inclination angles can be analyzed from the standpoint of energy, using the bond-base peridynamic theory and the PMB model of brittle materials, combined with laboratory experiments. The whole process of shearing is analyzed, and the LAMMPS software is used to simulate the internal energy change of rock-like materials under shear conditions, while the damage evolution law of samples with different dip angles is studied from macro and micro perspectives. The result shows that prefabricated cracks and the inclination of cracks are important factors for specimen damage, a finding that has important theoretical value for rock mechanics research. The research results can reduce the occurrence of rock burst accidents, the difficulty of mine support, and the cost of mining engineering, as well as improve mine safety levels.
Synthesis, experimental and computational studies on the anti-corrosion performance of substituted Schiff bases of 2-methoxybenzaldehyde for mild steel in HCl medium
Authors: Ibeji Collins U. , Akintayo Damilola C. , Oluwasola Henry O. , Akintemi Eric O. , Onwukwe Onyinye G. , Eziomume Onyeka M. 
Published: February 2023

AbstractCorrosion inhibition performance of two synthesized Schiff base ligands; (E)-2-((2-methoxybenzylidene)amino)phenol L1 and (E)-2-((4-methoxybenzylidene)amino)phenol L2 were carried out by weight loss measurement in 0.1 M hydrochloric acid (HCl) solution. Density Functional Theory (DFT) and Molecular dynamics (MD) simulation were applied to theoretically explain the inhibitors’ intrinsic properties and adsorption mechanism in the corrosion study. The result of the inhibition performances carried out at varying concentrations and temperatures were compared. The corrosion inhibition efficiencies of L1 and L2 at an optimal concentration of 10 × 10–4 M were 75% and 76%. Langmuir isotherm model fits the data obtained from the experiment with a correlation coefficient (R2) value closer to unity. The adsorption mechanism of inhibitor on the surface of the Fe metal occurred via chemisorption inferred from the Gibbs free energy (ΔGads). Scanning electron microscopy showed a mild degradation on the surface of the mild steel immersed in the L1, and L2 inhibited acid solution, which could be due to surface coverage. The energy dispersive X-ray spectroscopy showed the metal surface’s elemental composition and the existence of the chlorine peak, which emanates from the HCl medium. DFT calculations revealed that the hybrid B3LYP functional performed better than the M06-2X meta-functional in estimating the energies of the synthesized Schiff bases for corrosion inhibition as seen in the lower ΔE values of 3.86 eV and 3.81 eV for L1 and L2. The MD simulation revealed that the orientation of inhibitors on the surface of the metal resulted in the coordination bond formation and that the interaction energy of L2 was −746.84 kJ/mol compared to −743.74 kJ/mol of L1. The DFT and MD results agreed with the observed trend of the experimental findings.
Additional flight delays and magnetospheric–ionospheric disturbances during solar storms
Authors: Wang Y. , Xu X. H. , Wei F. S. , Feng X. S. , Bo M. H. , Tang H. W. , Wang D. S. , Bian L. , Wang B. Y. , Zhang W. Y. , Huang Y. S. , Li Z. , Guo J. P. , Zuo P. B. , Jiang C. W. , Xu X. J. , Zhou Z. L. , Zou P. 
Published: February 2023

AbstractAlthough the sun is really far away from us, some solar activities could still influence the performance and reliability of space-borne and ground-based technological systems on Earth. Those time-varying conditions in space caused by the sun are also called solar storm or space weather. It is known that aviation activities can be affected during solar storms, but the exact effects of space weather on aviation are still unclear. Especially how the flight delays, the top topic concerned by most people, will be affected by space weather has never been thoroughly researched. By analyzing huge amount of flight data (~ 4 × 106records), for the first time, we quantitatively investigate the flight delays during space weather events. It is found that compared to the quiet periods, the average arrival delay time and 30-min delay rate during space weather events are significantly increased by 81.34% and 21.45% respectively. The evident negative correlation between the yearly flight regularity rate and the yearly mean total sunspot number during 22 years also confirms such correlation. Further studies show that the flight delay time and delay rate will monotonically increase with the geomagnetic field fluctuations and ionospheric disturbances. These results indicate that the interferences in communication and navigation during space weather events may be the most probable reason accounting for the increased flight delays. The above analyses expand the traditional field of space weather research and could also provide us with brand new views for improving the flight delay predications.
Imaging biomarkers and clinical factors associated with the rate of progressive inner and outer retinal thinning in patients with diabetic macular edema
Authors: Borrelli Enrico , Barresi Costanza , Feo Alessandro , Lari Giorgio , Grosso Domenico , Querques Lea , Sacconi Riccardo , Bandello Francesco , Querques Giuseppe 
Published: February 2023

AbstractThe aim of this study was to assess the relationship of clinical characteristics to the rate of retinal thinning in eyes with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (VEGF) therapy. We analyzed subjects with a long-term follow-up (≥ 3 years) and evidence of resolved DME after the initiation of anti-VEGF therapy (baseline visit). To measure the long-term rate of retinal thinning during treatment, a second visit (first visit with evidence of resolved DME after 3 years) was also considered. A longitudinal quantitative topographical assessment of the inner and outer retinal thicknesses was provided. Clinical characteristics were associated with the rate of longitudinal retinal thinning. We included 56 eyes (50 patients) in the analysis. A significant longitudinal thinning in the inner and outer retina was detected in all the analyzed regions (p values between 0.027 and < 0.0001). In the multivariable analysis, type of diabetes (type 2 vs. type 1) was associated with increased foveal inner retinal thinning (p = 0.019). A higher number of subfoveal neuroretinal detachment during follow-up (p = 0.006) was associated with faster rates of foveal outer retinal thinning. Type of diabetes (p < 0.0001), higher age (p = 0.033) and cystoid macular edema phenotype (p = 0.040) were associated with increased parafoveal inner retinal thinning. Gender (p = 0.003) and diabetic retinopathy stage (p = 0.013) were associated with faster rates of perifoveal inner retinal thinning, while diabetic retinopathy stage (p = 0.036) was associated with increased perifoveal outer retinal thinning. In conclusion, clinical factors, including DME phenotypes, were associated with the rates of retinal thinning in patients undergoing anti-VEGF treatment.
Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells
Authors: Dolati Masoumeh , Tafvizi Farzaneh , Salehipour Masoud , Komeili Movahed Tahereh , Jafari Parvaneh 
Published: February 2023

AbstractThe present study examined the anticancer capabilities of Bacillus coagulans supernatant-produced copper oxide nanoparticles (BC-CuONPs) on MCF-7 and SKBR3 cancer cells. The X-ray diffraction, ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, field-emission scanning electron microscopy, energy-dispersive X-ray, dynamic light scattering, and zeta potential techniques were used to characterize BC-CuONPs. This study also investigated the cellular and molecular processes of NPs’ anti-proliferative and apoptotic properties on human breast cancer cells and compared them to the commercial pharmaceutical tamoxifen. The size of the spherical NP was from 5 to 47 nm with negative zeta potential. The MTT results showed the great cytotoxic effect of BC-CuONPs against breast cancer cells. The BC-CuONPs inhibited the growth of breast cancer cells in a time- and dose-dependent manner. The up-regulation of BCL2-associated X (BAX), cyclin dependent kinase inhibitor 1A (P21), Caspase 3 (CASP3), and Caspase 9 (CASP9), the down-regulation of BCL2 apoptosis regulator (BCL2), Annexin V-FITC/propidium iodide, and reactive oxygen species (ROS) generation results suggested that BC-CuONPs had a significant apoptotic impact when compared to the control. Scratch tests and vascular endothelial growth factor receptor gene (VEGF) down-regulation demonstrated that BC-CuONPs had anti-metastatic activity. The cell cycle analysis and down-regulation of Cyclin D1 (CCND1) and cyclin dependent kinase 4 (CDK4) revealed that cancer cells were arrested in the sub-G1 phase. Finally, the results showed that the secondary metabolites in the supernatant of Bacillus coagulans could form CuONPs, and biogenic BC-CuONPs showed anti-metastasis and anticancer properties on breast cancer cells while having less adverse effects on normal cells. Therefore, the synthesized CuONPs using B. coagulans supernatant can be shown as a potential candidate for a new therapeutic strategy in cancer management.
Noncontrast MRI in assessing venous reflux of legs using QFlow analysis and radial basis function neural network technique
Authors: Wong Min Yi , Chen Chien-Wei , Tseng Yuan-Hsi , Zhou Shao-Kui , Lin Yu-Hui , Huang Yao-Kuang , Lin Bor-Shyh 
Published: February 2023

AbstractSince venous reflux is difficult to quantify, triggered angiography non-contrast-enhanced (TRANCE)-magnetic resonance imaging (MRI) is a novel tool for objectively evaluating venous diseases in the lower extremities without using contrast media. This study included 26 pre-intervention patients with superficial venous reflux in the lower extremities and 15 healthy volunteers. The quantitative flow (QFlow) analyzed the phase shift information from the pixels within the region of interest from MRI. The fast and simple radial basis function neural network (RBFNN) learning model is constructed by determining the parameters of the radial basis function and the weights of the neural network. The input parameters were the variables generated through QFlow, while the output variables were morbid limbs with venous reflux and normal limb classification. The stroke volume, forward flow volume, absolute stroke volume, mean flux, stroke distance, and mean velocity of greater saphenous veins from QFlow analysis could be used to discriminate the morbid limbs of pre-intervention patients and normal limbs of healthy controls. The neural network successfully classified the morbid and normal limbs with an accuracy of 90.24% in the training stage. The classification of venous reflux using the RBFNN model may assist physicians in clinical settings.
Soil moisture revamps the temperature extremes in a warming climate over India
Authors: Ganeshi Naresh G. , Mujumdar Milind , Takaya Yuhei , Goswami Mangesh M. , Singh Bhupendra Bahadur , Krishnan R , Terao Toru 
Published: February 2023

AbstractSoil moisture (SM) plays a crucial role in altering climate extremes through complex land-atmosphere feedback processes. In the present study, we investigated the impact of SM perturbations on temperature extremes (ExT) over India for the historical period (1951–2010) and future climate projection (2051–2100) under 4 K warming scenario. We note that more than 70% area of the Indian landmass has experienced significant changes in characteristics of ExT due to SM perturbations. In particular, we see larger impact of SM perturbations on ExT over the north-central India (NCI), which is a hotspot of strong SM-temperature coupling. Over NCI, a 20% departure in SM significantly revamps frequency, duration and intensity of ExT by 2–5 events/year, 1-2 days/event and 0.5–2.1 °C, respectively, through modulating surface energy partitioning, evapotranspiration and SM memory. Importantly, the impact of SM perturbations on frequency and duration of ExT events becomes less prominent with intensification of global warming.
Enhanced mitochondrial biogenesis promotes neuroprotection in human pluripotent stem cell derived retinal ganglion cells
Authors: Surma Michelle , Anbarasu Kavitha , Dutta Sayanta , Olivera Perez Leonardo J. , Huang Kang-Chieh , Meyer Jason S. , Das Arupratan 
Published: February 2023

AbstractMitochondrial dysfunctions are widely afflicted in central nervous system (CNS) disorders with minimal understanding on how to improve mitochondrial homeostasis to promote neuroprotection. Here we have used human stem cell differentiated retinal ganglion cells (hRGCs) of the CNS, which are highly sensitive towards mitochondrial dysfunctions due to their unique structure and function, to identify mechanisms for improving mitochondrial quality control (MQC). We show that hRGCs are efficient in maintaining mitochondrial homeostasis through rapid degradation and biogenesis of mitochondria under acute damage. Using a glaucomatous Optineurin mutant (E50K) stem cell line, we show that at basal level mutant hRGCs possess less mitochondrial mass and suffer mitochondrial swelling due to excess ATP production load. Activation of mitochondrial biogenesis through pharmacological inhibition of the Tank binding kinase 1 (TBK1) restores energy homeostasis, mitigates mitochondrial swelling with neuroprotection against acute mitochondrial damage for glaucomatous E50K hRGCs, revealing a novel neuroprotection mechanism.
Systematic screening of gas diffusion layers for high performance CO2 electrolysis
Authors: Samu Angelika Anita , Szenti Imre , Kukovecz Ákos , Endrődi Balázs , Janáky Csaba 
Published: February 2023

AbstractCertain industrially relevant performance metrics of CO2 electrolyzers have already been approached in recent years. The energy efficiency of CO2 electrolyzers, however, is yet to be improved, and the reasons behind performance fading must be uncovered. The performance of the electrolyzer cells is strongly affected by their components, among which the gas diffusion electrode is one of the most critical elements. To understand which parameters of the gas diffusion layers (GDLs) affect the cell performance the most, we compared commercially available GDLs in the electrochemical reduction of CO2 to CO, under identical, fully controlled experimental conditions. By systematically screening the most frequently used GDLs and their counterparts differing in only one parameter, we tested the influence of the microporous layer, the polytetrafluoroethylene content, the thickness, and the orientation of the carbon fibers of the GDLs. The electrochemical results were correlated to different physical/chemical parameters of the GDLs, such as their hydrophobicity and surface cracking.
The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway
Authors: Li Guo-li , Tang Jia-feng , Tan Wen-li , Zhang Tao , Zeng Di , Zhao Shuang , Ran Jian-hua , Li Jing , Wang Ya-ping , Chen Di-long 
Published: February 2023

Ganoderma lucidum polysaccharide (GLPS) can inhibit hepatocellular carcinoma (HCC). But the mechanism of GLPS's effect is little known. This data showed that GLPS can regulate MAPK/NF-κB signaling responsible for M1 polarization in anti-HCC.
A base-free hydroxylaminolysis protocol promoted by ZnO in deep eutectic solvents
Authors: Liang Xinjie , Lv Bingqing , Sun Shitao , Wu Zhixuan , Lin Bin , Bao Xuefei , Chen Guoliang 
Published: February 2023

The work-up was an integration of product purification and resource recovery, which reduced PMI and WI. The recyclability of both zinc oxide and DESs was proved via the preparation of vorinostat at the gram scale for at least four consecutive runs.
Impact of Face Masks on Speech in Parkinson's Disease: Effect of Clear and Loud Speech Styles
Authors: Knowles Thea , Badh Gursharan 
Published: February 2023

Purpose:
The purpose of this study is to quantify the combined effects of face masks and effortful speech styles on speech intensity, spectral moments, and measures of spectral balance in talkers with Parkinson's disease.

Method:
Fifteen people with Parkinson's disease and 15 healthy, older controls read aloud sentences in three face mask conditions and three speech style conditions. Mask conditions included no mask, surgical masks, and KN95 masks. Speech styles included habitual, clear, and loud. Acoustic measures of intensity, spectral moments, and spectral balance were modeled as a function of speaker group, mask, and speech style.

Results:
Overall, talkers with PD demonstrated lower concentrations of high-frequency spectral energy in their speech. Face masks attenuated high-frequency energy, whereas clear followed by loud speaking styles amplified high frequencies. Overall, the attenuation observed by face masks was preserved across speech styles, and both mask and speech patterns were observed to be similar across groups.

Discussion:
Clear and loud speech styles were effective in compensating for the damping effects of masks in talkers with and without PD. However, given that people with PD demonstrated poorer overall spectral balance compared to controls, the gains afforded by speaking clearly or loudly may be limited when wearing a face mask.
Robotic disassembly sequence planning considering parts failure features
Authors: Cui Jia , Yang Can , Zhang Jinliang , Tian Sisi , Liu Jiayi , Xu Wenjun 
Published: February 2023

AbstractDisassembly is an important step in remanufacturing products. Robotic disassembly helps to improve disassembly efficiency. However, the end‐of‐life products often have the parts with uncertain quality, which is manifested as wear, fracture, deformation, corrosion, and other failure features. The parts failure features always have impacts on disassembly process. First, the evaluation method of parts failure features is researched, and the quantitative model of parts failure features is constructed using fuzzy models. Then, the disassembly information model is established by considering the influence of different failure degrees on the robotic disassembly process. Afterwards, to generate the optimal disassembly solution, deep reinforcement learning (DRL) is used to solve robotic disassembly sequence planning problem which considers parts failure features. Considering the influence of parts failure features on robotic disassembly time, the states, actions and rewards and environment are designed in DRL. Finally, a case study of the double shaft coupling as a waste product is carried out, and the proposed method is compared with the other methods to verify the effectiveness.
Diagnostisches und therapeutisches Management der Episkleritis und Skleritis
Authors: Turgut Ferhat , Dingerkus Vita , Tappeiner Christoph , Becker Matthias 
Published: February 2023

ZusammenfassungDas schmerzhafte „rote Auge“ ist wohl das auffälligste Zeichen einer Augenerkrankung, hinter der milde, aber auch schwere Verläufe stecken können. Die Episkleritis und Skleritis sind
hierbei wichtige Differenzialdiagnosen. Die rechtzeitige Diagnose ist nicht nur wichtig für die notwendige Therapie, sondern kann vor einer irreversiblen Visusminderung, einem Augenverlust
sowie Organschäden schützen und ggf. sogar das Mortalitätsrisiko senken.
Appendiceal lesions in serrated polyposis patients are easily overlooked but only seldomly lead to colorectal cancer
Authors: van Toledo David E. F. W. M. , IJspeert Joep E. G. , Bleijenberg Arne G. C. , Bastiaansen Barbara A. J. , van Noesel Carel J. M. , Dekker Evelien 
Published: February 2023

Background Serrated polyposis syndrome (SPS) is the most prevalent colonic polyposis syndrome and is associated with an increased colorectal cancer risk. A recent study in resected appendices of SPS patients reported that 6/23 (26.1 %) of identified serrated polyps had histological dysplasia. We evaluated the prevalence and clinical relevance of appendiceal lesions in a large SPS cohort.
Methods Prospective data from 2007 to 2020 for a cohort of 199 SPS patients were analyzed. Data were retrieved from endoscopy and pathology reports. Patients who underwent (pre)clearance colonoscopies, surveillance colonoscopies, or colorectal surgery including the appendix were separately evaluated for the presence of appendiceal lesions. The primary outcome was the prevalence of adenocarcinomas and serrated polyps/adenomas with advanced histology in the surgery group.
Results 171 patients were included, of whom 110 received endoscopic surveillance and 34 underwent surgery. Appendiceal lesion prevalence in the surgery group was 14 /34 (41.2 %, 95 %CI 24.7 %–59.3 %); none were advanced on histology. Detection rates in the (pre)clearance group were 1 /171 (0.6 %, 95 %CI 0.01 %–3.2 %) for advanced and 3 /171 (1.8 %, 95 %CI 0.04 %–5.0 %) for nonadvanced appendiceal lesions, all of which were sessile serrated lesions. During 522 patient-years of surveillance, no advanced appendiceal lesions were detected at endoscopy, and in 1 /110 patients (0.9 %, 95 %CI 0.02 %–5.0 %) was a nonadvanced lesion detected.
Conclusion Appendiceal lesions are common in SPS patients. The discrepancy between the endoscopic detection rate of appendiceal lesions and the reported prevalence in surgically resected appendices suggests a substantial miss-rate of appendiceal lesions during colonoscopy. Advanced appendiceal lesions are however rare and no appendiceal adenocarcinomas occurred, implying limited clinical relevance of these lesions.