bluuebunny/crossref_metadata_2025_split huggingface dataset:
TESLA Trial: Rationale, Protocol, and Design
Authors: Zaidat Osama O. , Kasab Sami Al , Sheth Sunil , Ortega‐Gutierrez Santiago , Rai Ansaar T. , Given Curtis A. , Grandhi Ramesh , Mokin Maxim , Katz Jeffrey M. , Maud Alberto , Gupta Rishi , Smith Wade S. , Dippel Diederik W. , Gress Daryl , Nguyen Thanh N. , Brown Scott , Jadhav Ashutosh P. , Eljovich Lucas , Majoie Charles , Patterson Mary S. , Slight Hannah , Below Kristine , Yoo Albert J. 
Published: May 2023

Background
Mechanical thrombectomy has been shown to be effective in patients with acute ischemic stroke secondary to large‐vessel occlusion and small to moderate infarct volume. However, there are no randomized clinical trials for large‐core infarct volume comparing mechanical thrombectomy to medical therapy in the population selected based solely on noncontrast computed tomography brain scan. The TESLA (Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke) randomized clinical trial is designed to address this clinical question.

Methods
The TESLA trial aim is to demonstrate the efficacy (3‐month and 1‐year disability following stroke) and safety of intraarterial mechanical thrombectomy in patients with large‐volume infarction assessed with a noncontrast computed tomography scan. The TESLA trial design is a prospective, randomized controlled, multicenter, open‐label, assessor‐blinded anterior circulation acute ischemic stroke trial with adaptive enrichment design, enrolling up to 300 patients. Patients with anterior circulation large‐vessel occlusion who meet the imaging and clinical eligibility criteria with a large‐core infarction on the basis of noncontrast computed tomography Alberta Stroke Program Early CT Score (2–5) adjudicated by a site investigator will be randomized in a 1:1 ratio to undergo intraarterial thrombectomy or best medical management up to 24 hours from last known well.

Results
The primary efficacy outcome is utility‐weighted modified Rankin Scale (mRS) score distribution at 90 days between the groups. The results will be based on an intention‐to‐treat analysis that will examine the Bayesian posterior probability that, adjusted for Alberta Stroke Program Early CT Score, patients with large‐core infarct volume treated with intra‐arterial thrombectomy have higher expected utility‐weighted mRS than those treated with best medical management alone. The primary safety outcome is the 90‐day death rate. Key secondary outcomes are dichotomized mRS 0 to 2 and 0 to 3 outcomes, ordinal mRS scores, and quality of life (EuroQol 5 Dimension 5 Level survey) at 90 days and 1 year, utility‐weighted mRS at 1 year, hemicraniectomy rate, and rate of 24‐hour symptomatic intracranial hemorrhage in both groups.

Conclusion
TESLA is a pragmatic trial, designed to address the unanswered question of the efficacy and safety of intra‐arterial thrombectomy in patients with large infarcts diagnosed by the site investigator only on noncontrast computed tomography scan secondary to anterior circulation large‐vessel occlusion up to 24 hours from stroke symptoms onset.
Contrasting Intraurban Signatures of Humid and Dry Heatwaves over Southern California
Authors: Shreevastava Anamika , Raymond Colin , Hulley Glynn C. 
Published: May 2023

Abstract
Heatwaves in California manifest as both dry and humid events. While both forms have become more prevalent, recent studies have identified a shift toward more humid events. Understanding the complex interactions of each heatwave type with the urban heat island is crucial for impacts but remains understudied. Here, we address this gap by contrasting how dry versus humid heatwaves shape the intraurban heat of the greater Los Angeles area. We used a consecutive contrasting set of heatwaves from 2020 as a case study: a prolonged humid heatwave in August and an extremely dry heatwave in September. We used MERRA-2 reanalysis data to compare mesoscale dynamics, followed by high-resolution Weather Research and Forecasting modeling over urbanized Southern California. We employ moist thermodynamic variables to quantify heat stress and perform spatial clustering analysis to characterize the spatiotemporal intraurban variability. We find that, despite temperatures being 10° ± 3°C hotter in the September heatwave, the wet-bulb temperature, closely related to the risk of human heat stroke, was higher in August. While dry and humid heat display different spatial patterns, three distinct spatial clusters emerge based on nonheatwave local climates. Both types of heatwaves diminish the intraurban heat stress variability. Valley areas such as San Bernardino and Riverside experience the worst impacts, with up to 6° ± 0.5°C of additional heat stress during heatwave nights. Our results highlight the need to account for the disparity in small-scale heatwave patterns across urban neighborhoods in designing policies for equitable climate action.

Significance Statement
Heatwaves are the leading cause of morbidity and mortality among all environmental hazards. Moreover, their frequency and intensity are on the rise due to climate change. Southern California is no stranger to extreme heat, but persistently humid heatwaves still test the adaptability limits of its residents. We find that the set of two contrasting heatwaves that afflicted Los Angeles in the summer of 2020 forms the perfect testbed for characterizing the impacts of humid versus dry heatwaves on urban environment. Because climate model forecasts and long-term observational trends point to more humid heatwaves in the future for Southern California, our results underscore the importance of including moist heat in extreme heat warning frameworks.
Can the effects of high school culinary nutrition education be sustained into adulthood?
Authors: Fredericks Lynn , Utter Jennifer , Tang Lucille , Shah Anjuman , Wilson Lofts Casey , Parry Jade , Koch Pamela A. 
Published: May 2023

Objective: To assess whether adolescents who appeared in an after-school cooking nutrition programme (Teen Battle Chef) sustained healthful food behaviours in the ensuing years into young adulthood. Design: Interviews involving a short verbal survey assessing six health behaviours coded dichotomously and open-ended questions coded for themes describing how participants did or did not sustain behaviour change. Setting: Adults who had previously participated in TBC culinary nutrition programme while in high school discussed whether any lifestyle changes prompted by the programme continued into their adult lives. Method: The 30 young people were interviewed (in-person or by telephone) and the interviews were audio-recorded. Transcripts were made verbatim to allow for NVivo analysis of responses. Results: Thirty 17- to 24-year-olds, 6 months to 7 years after TBC programme, reported current favourable health behaviours. Results were similar for participants <3 and 3+ years post TBC. In interviews, 27 of 30 provided in-depth description of how TBC had changed their behaviours. They described cooking skills learned in TBC that they still practised. Participants discussed specific ways in which peers and family supported them to sustain behaviour change. Conclusion: Even modest findings of short-term evaluations of cooking programmes may be significant if impacts are sustained. More longer-term evaluations are needed to confirm these results.
Social Supply and the Potential for Harm Reduction in Social Media Drug Markets
Authors: van der Sanden Robin , Wilkins Chris , Rychert Marta , Barratt Monica J. 
Published: May 2023

Background Existing studies have highlighted the potential for increased drug market risks from buying drugs via social media involving strangers, such as receiving adulterated drugs or being robbed. However, social supply-driven social media drug markets may also offer enhanced social dealing and harm reduction opportunities. Aim To explore how social media platform features that enable expanded social networking may also support safer social drug dealing and other harm-reduction behaviors. Method Thematic analysis of anonymous online interviews with 33 people who buy and sell drugs via social media in New Zealand. Results Participants (median age 24; 22 male, 10 female, 1 gender diverse) accessing drugs via social media mostly utilized established social networks. These personal networks offered many benefits commonly associated with social media drug trading (i.e., safer and secure drug purchasing). Benefits included reducing the risk of receiving adulterated substances and being victimized. Social media affordances, which participants used to expand their everyday social networks, could also increase participants’ ability to leverage a broader social drug supply network and access related harm reduction benefits. Some participants used darknet markets to buy drugs, which they then resold to “friends” via social media platforms, facilitating supply channels that were largely “separated” from local physical drug markets and associated problems of fraud, violence, and organized crime. Conclusion Social media drug markets offer a range of harm reduction benefits that contribute to a lower-risk local drug market. We suggest this may reflect a closer alignment between social media platform affordances and their adaptation to social supply drug trading.
Management of Epidural and Subgaleal Abscesses in Pediatric Craniosynostosis Surgery
Authors: Arslan Muhammad , Smola Cassi , Soto Edgar , Rahman AKM F. , Grant John H. , Johnston James M. 
Published: May 2023

Introduction: Epidural/subgaleal abscesses in craniosynostosis surgery are rare but serious complications that may compromise neurological functioning in pediatric craniofacial populations. We evaluated the risk and evolution of management of post-operative subgaleal/epidural abscesses in craniosynostosis patients treated over 20 years by a single surgeon. Methods: Pediatric patients who underwent transcranial procedures for craniosynostosis by a single surgeon from 1997 to 2018 were included. The patients were stratified into groups based on the development of post-op abscess. The primary outcome measure was bone salvage success. Post-op abscesses were drained in the following manner: either open packing with delayed closure or no elevation of the scalp flap, followed by copious irrigation and deep (epidural) drain placement plus long-term intravenous antibiotics. Results: A total of 384 patients underwent 413 cases in this period: 177 sagittal, 85 unicoronal, 49 metopic, 4 lambdoid, and 69 cases of multiple suture synostosis. In this cohort, epidural/subgaleal abscess were found in 6 patients (1.5%) who all had bilateral fronto-orbital advancement ( P = .03). Bone salvage was attempted in all 6 patients with only minor bone resorption seen in 3 of the patients who presented with abscess. Conclusion: This study found that patients undergoing bilateral fronto-orbital advancement were at increased risk of a deep space infections, while those undergoing clavarial vault remodeling with barrel staves alone, were not. We were able to salvage the bone grafts and prevent neurological sequela with surgical washout, placement of drains and intravenous antibiotic therapy.
Vrančiceite, Cu10Hg3S8, a new Cu–Hg sulfide mineral from Vrančice, Czech Republic
Authors: Sejkora Jiří , Biagioni Cristian , Škácha Pavel , Mauro Daniela 
Published: May 2023

AbstractVrančiceite is a new mineral species discovered in a sample collected from the old mine dumps of the abandoned Vrančice deposit near Příbram, central Bohemia, Czech Republic. Vrančiceite occurs as rare anhedral grains, up to 100 μm in size, in a calcite gangue, associated with cinnabar, djurleite, galena and hedyphane. Vrančiceite is black, with metallic lustre. Mohs hardness is ca. 2–3, calculated density is 6.652 g.cm–3. In reflected light, vrančiceite is light grey with a yellowish shade; bireflectance, pleochroism and anisotropy are all weak. Internal reflections were not observed. Reflectance values for the four Commission on Ore Mineralogy wavelengths of vrančiceite in air [Rmax, Rmin (%) (λ in nm)] are: 33.6, 31.2 (470); 33.9, 30.6 (546); 31.1, 30.0 (589); and 32.1, 29.1 (650). The empirical formula, based on electron-microprobe analyses, is Cu10.11(4)Ag0.01(1)Hg2.87(4)Sb0.01(1)Bi0.01(1)S7.99(8). The ideal formula is Cu10Hg3S8 (Z = 2), which requires (in wt.%) Cu 42.54, Hg 40.29 and S 17.17, total 100.00. Vrančiceite is triclinic, P$\bar{1}$, with unit-cell parameters a = 7.9681(2), b = 9.7452(3), c = 10.0710(3) Å, α = 77.759(1), β = 76.990(1), γ = 79.422(1)°, V = 737.01(4) Å3 and Z = 2. The strongest reflections of the calculated powder X-ray diffraction pattern [d, Å (I) hkl] are: 3.354 (76) $\bar{2}$01, 3.111 (68) 222, 2.833 (100) 213, 2.733 (93) 231, 2.705 (76) 2$\bar{2}$1 and 2.647 (71) $\bar{2}\bar{1}$2. According to the single-crystal X-ray diffraction data (R1 = 0.0262), the crystal structure of vrančiceite can be described as comprising Cu–S layers, connected through CuS3 polyhedra, giving rise to a three-dimensional framework with channels running along the a axis and hosting linearly coordinated Hg atoms. Structural relations with gortdrumite are discussed. Vrančiceite is named after its type locality, the Vrančice deposit near Příbram. The mineral and its name have been approved by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association (IMA2022–114).
Prospective PTCTC trial of myeloablative haplo-BMT with posttransplant cyclophosphamide for pediatric acute leukemias
Authors: Fierro-Pineda Juan C. , Tsai Hua-Ling , Blackford Amanda , Cluster Andrew , Caywood Emi , Dalal Jignesh , Davis Jeffrey , Egeler Maarten , Huo Jeffrey , Hudspeth Michelle , Keating Amy , Kelly Susan S. , Krueger Joerg , Lee Dean , Lehmann Leslie , Madden Lisa , Oshrine Benjamin , Pulsipher Michael A. , Fry Terry , Symons Heather J. 
Published: May 2023

Abstract
Promising results have been reported for adult patients with high-risk hematologic malignancies undergoing haploidentical bone marrow transplant (haploBMT) with posttransplant cyclophosphamide (PTCy). To our knowledge, we report results from the first multicenter trial for pediatric and young adult patients with high-risk acute leukemias and myelodysplastic syndrome (MDS) in the Pediatric Transplantation and Cellular Therapy Consortium. Nine centers performed transplants in 32 patients having acute leukemias or MDS, with myeloablative conditioning (MAC), haploBMT with PTCy, mycophenolate mofetil, and tacrolimus. The median patient age was 12 years. Diagnoses included AML (15), ALL (11), mixed-lineage leukemia (1), and MDS (5). Transplant-related mortality (TRM) at 180 days was 0%. The cumulative incidence (CuI) of grade 2 acute graft-versus-host disease (aGVHD) on day 100 was 13%. No patients developed grades 3-4 aGVHD. The CuI of moderate-to-severe chronic GVHD (cGVHD) at 1 year was 4%. Donor engraftment occurred in 27 patients (84%). Primary graft failures included 3 patients who received suboptimal bone marrow grafts; all successfully engrafted after second transplants. The CuI of relapse at 1 year was 32%, with more relapse among patients MRD positive pre-BMT vs MRD negative. Overall survival rates at 1 and 2 years were 77% and 73%, and event-free survival rate at 1 and 2 years were 68% and 64%. There was no TRM or severe aGVHD, low cGVHD, and favorable relapse and survival rates. This successful pilot trial has led to a phase 3 trial comparing MAC haploBMT vs HLA-matched unrelated donor BMT in the Children’s Oncology Group. This trial was registered at www.clinicaltrials.gov as #NCT02120157.
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity
Authors: Cheng Lian-sheng , Zhu Min , Gao Yan , Liu Wen-ting , Yin Wu , Zhou Pengfei , Zhu Zhongliang , Niu Liwen , Zeng Xiaoli , Zhang Dayan , Fang Qing , Wang Fengrong , Zhao Qun , Zhang Yan , Shen Guodong 
Published: May 2023

Abstract
Background
Resistance to immune checkpoint inhibitor (ICI) therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB is a promising drug target as a costimulatory molecule of immune cells, no 4-1BB agonist has been given clinical approval because of severe liver toxicity or limited efficacy. Therefore, a safe and efficient immunostimulatory molecule is urgently needed for cancer immunotherapy.

Methods
HK010 was generated by antibody engineering, and the Fab/antigen complex structure was analyzed using crystallography. The affinity and activity of HK010 were detected by multiple in vitro bioassays, including enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), flow cytometry, and luciferase-reporter assays. Humanized mice bearing human PD-L1-expressing MC38 (MC38/hPDL1) or CT26 (CT26/hPDL1) tumor transplants were established to assess the in vivo antitumor activity of HK010. The pharmacokinetics (PK) and toxicity of HK010 were evaluated in cynomolgus monkeys.

Results
HK010 was generated as an Fc-muted immunoglobulin (Ig)G4 PD-L1x4-1BB bispecific antibody (BsAb) with a distinguished Fab/antigen complex structure, and maintained a high affinity for human PD-L1 (KD: 2.27 nM) and low affinity for human 4-1BB (KD: 493 nM) to achieve potent PD-1/PD-L1 blockade and appropriate 4-1BB agonism. HK010 exhibited synergistic antitumor activity by blocking the PD-1/PD-L1 signaling pathway and stimulating the 4-1BB signaling pathway simultaneously, and being strictly dependent on the PD-L1 receptor in vitro and in vivo. In particular, when the dose was decreased to 0.3 mg/kg, HK010 still showed a strong antitumor effect in a humanized mouse model bearing MC38/hPDL1 tumors. Strikingly, HK010 treatment enhanced antitumor immunity and induced durable antigen-specific immune memory to prevent rechallenged tumor growth by recruiting CD8+ T cells and other lymphocytes into tumor tissue and activating tumor-infiltrating lymphocytes. Moreover, HK010 not only did not induce nonspecific production of proinflammatory cytokines but was also observed to be well tolerated in cynomolgus monkeys in 5 week repeated-dose (5, 15, or 50 mg/kg) and single-dose (75 or 150 mg/kg) toxicity studies.

Conclusion
We generated an Fc-muted anti-PD-L1x4-1BB BsAb, HK010, with a distinguished structural interaction with PD-L1 and 4-1BB that exhibits a synergistic antitumor effect by blocking the PD-1/PD-L1 signaling pathway and stimulating the 4-1BB signaling pathway simultaneously. It is strictly dependent on the PD-L1 receptor with no systemic toxicity, which may offer a new option for cancer immunotherapy.
Utility of urinary presepsin in the diagnosis of pyelonephritis: a cross-sectional study
Authors: Yamashita Ryo , Izumi Yusuke , Nakada Koji , Hiramoto Jun 
Published: May 2023

Abstract
Background
Presepsin is produced during the phagocytosis of bacteria by granulocytes. Presepsin increases at the site of infection; however, the significance of urinary presepsin in pyelonephritis is unknown. This study aimed to evaluate whether measuring urinary presepsin can distinguish between pyelonephritis and nonpyelonephritis.

Methods
A cross-sectional study of patients with suspected pyelonephritis was conducted. Urinary presepsin at admission was compared between the pyelonephritis and nonpyelonephritis groups using the Mann–Whitney test. The predictive accuracy of urinary presepsin for diagnosing pyelonephritis was evaluated by the area under the receiver operating characteristics (ROC) analysis curve.

Results
A total of 35 eligible participants were included in the pyelonephritis group and 25 in the nonpyelonephritis group. The median urinary presepsin level was 2232.0 (interquartile range [IQR], 1029.0–3907.0) pg/mL in the pyelonephritis group and 1348.0 (IQR, 614.5–2304.8) pg/mL in the nonpyelonephritis group. Urinary presepsin concentrations were significantly higher in the pyelonephritis group than in the nonpyelonephritis group (P = 0.023). ROC analysis of urinary presepsin revealed a cutoff value of 3650 pg/mL to distinguish between the pyelonephritis and nonpyelonephritis groups. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio for the diagnosis of pyelonephritis were 0.40 (95% confidence interval [CI], 0.24–0.58), 0.96 (95% CI, 0.79–1.00), 0.93 (95% CI, 0.68–1.00), 0.52 (95% CI, 0.37–0.68), 9.60 (95% CI, 1.35–68.23), and 0.62 (95% CI, 0.47–0.83), respectively.

Conclusions
The measurement of urinary presepsin is useful in differentiating pyelonephritis from other diseases.
Correlation between overall survival and quality of life in colon cancer patients with chemotherapy
Authors: Murakawa Yasuko , Ootsuka Kazunori , Kusaka Jun , Miura Kou 
Published: May 2023

Abstract
Background
Patients presenting with inoperable colon cancer at first onset (ICF) or at time of relapse (ICR) are considered in unrecoverable. The therapeutic goal for unrecoverable cancer is to prolong overall survival (OS) and maintain a high quality of life (QOL). As data on objective indicators of QOL in cancer patients, such as length of hospitalisation (LOH), outpatient consultation times (OCT), and hospital-free survival (HFS), is limited, this study compared ICF and ICR with respect to OS and QOL over the entire clinical course.

Methods
We retrospectively evaluated 90 inoperable colon cancer patients with chemotherapy and compared ICF and ICR in terms of OS, LOH, OCT, and HFS.

Results
Patients with ICF had a worse OS than those with ICR. In patients with ICF and ICR, OS and LOH were not correlated but OS and OCT and OS and HFS were strongly correlated. In patients with ICF and ICR, OCT and HFS accounted for approximately 8% and 90% of their OS, respectively.

Conclusions
The LOH, OCT, and HFS are important factors for evaluating objective QOL of patients with inoperable colon cancer and should be considered when making treatment decisions.
A novel predictive model for phthisis bulbi following facial hyaluronic acid cosmetic injection
Authors: Si Shancheng , Su Wei , Wang Lei , Ji Yicong , Chen Anming , Hu Yuntao 
Published: May 2023

Abstract
Purpose
To observe long-term prognosis of anterior segment ischemia (ASI) following hyaluronic acid (HA) injection, propose a severity grading system for ASI and a predictive model for phthisis bulbi (PB) based on long-term secretion dysfunction of ciliary process.

Methods
This is a retrospective case–control study. All enrolled 20 patients were divided into two groups and followed for at least 6 months to observe the formation and transformation characteristics of ASI and long-term prognosis based on the degrees of ciliary function damage.

Results
The severity of ASI following HA injection could be subdivided into 4 grades according to the degrees of ciliary function damage, comprising ASI grades 0, 1, 2 and 3. In 20 patients, ophthalmoplegia at 1-month follow-up, ASI within 1 month, ASI at 1-month follow-up, hypotony within 6 months were all significantly more common in study group than in control group (60% vs. 0%, P = 0.011; 100% vs. 20%, P = 0.001; 100% vs. 0%, P < 0.001; 80% vs. 0%, P = 0.001, respectively). Sensitivity, specificity and the area under the receiver operating characteristic curve (AUC) for predicting subsequent PB at 2-year follow-up through the co-occurrence of ophthalmoplegia at 1-month follow-up and hypotony within 6 months was 100%, 100% and 1.00, respectively.

Conclusions
The new grading system for ASI and novel predictive model for PB we proposed could predict the long-term prognosis and probability of subsequent PB due to ASI following HA injection through several dynamic assessments within 6 months.

Level of Evidence
Level IV, observational prognostic study.