bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the reliability of CBCT-based AI-generated STL files in diagnosing osseous changes of the mandibular condyle: a comparative study with ground truth diagnosis
Authors: Orhan Kaan , Sanders Alex , Ünsal Gürkan , Ezhov Matvey , Mısırlı Melis , Gusarev Maxim , İçen Murat , Shamshiev Mamat , Keser Gaye , Namdar Pekiner Filiz , Golitsyna Maria , Önder Merve , Manulis David , Atakan Cemal 
Published: August 2023

Objectives:
This study aims to evaluate the reliability of AI-generated STL files in diagnosing osseous changes of the mandibular condyle and compare them to a ground truth (GT) diagnosis made by six radiologists.

Methods:
A total of 432 retrospective CBCT images from four universities were evaluated by six dentomaxillofacial radiologists who identified osseous changes such as flattening, erosion, osteophyte formation, bifid condyle formation, and osteosclerosis. All images were evaluated by each radiologist blindly and recorded on a spreadsheet. All evaluations were compared and for the disagreements, a consensus meeting was held online to create a uniform GT diagnosis spreadsheet. A web-based dental AI software was used to generate STL files of the CBCT images, which were then evaluated by two dentomaxillofacial radiologists. The new observer, GT, was compared to this new STL file evaluation, and the interclass correlation (ICC) value was calculated for each pathology.

Results:
Out of the 864 condyles assessed, the ground truth diagnosis identified 372 cases of flattening, 185 cases of erosion, 70 cases of osteophyte formation, 117 cases of osteosclerosis, and 15 cases of bifid condyle formation. The ICC values for flattening, erosion, osteophyte formation, osteosclerosis, and bifid condyle formation were 1.000, 0.782, 1.000, 0.000, and 1.000, respectively, when comparing diagnoses made using STL files with the ground truth.

Conclusions:
AI-generated STL files are reliable in diagnosing bifid condyle formation, osteophyte formation, and flattening of the condyle. However, the diagnosis of osteosclerosis using AI-generated STL files is not reliable, and the accuracy of diagnosis is affected by the erosion grade.
Impact of brand equity and service quality on the reputation of universities and students’ intention to choose them: The case of IIUM and UIN
Authors: Rizard Sylvia Rozza , Waluyo Bambang , Jaswir Irwandi 
Published: August 2023

Background:Numerous studies have been carried out on the impacts of brand equity and service quality of higher education institutions (HEIs) on their reputation and students’ satisfaction. This research aimed to compare the impact of brand equity and service quality on universities’ reputations, namely Universitas Islam Negeri (UIN) in Indonesia and International Islamic University Malaysia (IIUM) in Malaysia, and Indonesian students’ intention to choose the universities, which is moderated by study expense (price). UIN and IIUM are HEIs with a similar university concept, and Indonesian students have recently shown a high interest in them. The two universities have faculties not only in the field of Islamic studies but in general fields of studies as well, which are usually held by non-Islamic Universities. Therefore, their competitiveness against non-Islamic universities, especially the University of Indonesia (UI) has increased.Methods:The statistical measurement tool used was structural equation modeling (SEM). The number of items stated in the questionnaire was 45. Therefore, minimum data to be collected were 5 × 45 or 225 which rounded up to 228 from Indonesian students at UIN and IIUM (114 UIN students, and 114 Indonesian student respondents from IIUM).Results:The study results show that the universities’ reputations are strongly affected by their brand equity and service quality, which then affect students’ intention to choose the universities. Students had a higher intention to choose IIUM than UIN. The limitation of this research is that the effect of study expense on the intention of Indonesian students to study at UIN or IIUM has not yet been conducted. It will be conducted in the next study.Conclusions:These results are expected to be useful to UIN, IIUM, and especially Politeknik Negeri Jakarta (PNJ) in determining a strategy to enhance their reputations and the intention of Indonesian students to study there.
Methylene blue sentinel lymph node biopsy for breast cancer learning curve in the COVID-19 era: How many cases are enough?
Authors: Azhar Yohana , Dewayani Birgitta M. , Lukman Kiki 
Published: August 2023

Background: Sentinel lymph node biopsy (SLNB) is now the gold standard for early breast cancer with clinically negative lymph nodes (N0). According to the Indonesian Board-Certified oncologist surgeon, the learning curve for evaluating fellow breast surgeons to achieve this competency could have been shorter due to the COVID-19 pandemic. This study aims to see if the learning curve for sentinel lymph node (SLN) identification can be shortened. Methods: Trainee breast surgeons were taught to perform SLNB on breast cancer patients. Intraoperative assessment and completion of axillary lymph node dissection (ALND) were performed in the first setting for standardization with the attending surgeon. Sentinel lymph node identification was plotted on cumulative sum chart (CUSUM) limitations for evaluating the variability competency between the attending and trainee surgeons based on a target identification rate of 85%. Results: We concluded that CUSUM charts are the best tools currently available for assessing psychomotor learning SLNB. According to a CUSUM chart based on a reasonable set of parameters, the learning curve for SLNB using methylene blue dye is reached after 4-5 consecutive positively detected SLN. Conclusion: CUSUM Chart showed that experienced breast surgeons have completed the SLNB learning curve after 4-5 successful methylene blue attempts. In the future, this learning curve analysis can be applied to trainee breast surgeons by utilizing a proxy measure for failure, such as failure to identify the SLN.
Optimal control model of human-to-human transmission of monkeypox virus
Authors: Ackora-Prah Joseph , Okyere Samuel , Bonyah Ebenezer , Adebanji Atinuke Olusola , Boateng Yaw 
Published: August 2023

Background: The number of monkeypox cases is rising globally, but it’s unclear how many instances there will be in the near future. The disease has been one of the major problems for sub-Saharan Africans in the past few years. This study seeks to suggest optimal strategies for curbing the disease in Ghana and preventing future occurrences. Methods: A deterministic mathematical model incorporating optimal controls has been developed in this research to investigate the transmission of the monkeypox virus. The model’s fundamental properties such as positivity and boundedness of solution, and basic reproduction number have been examined. In order to assess the efficacy of two preventative control strategies—public education and vaccination—optimal controls were included in the model and Pontragyin’s maximum principle was used to characterize the model. Results: The disease was observed to be not endemic with infection going extinct after ten days. The Monkeypox-related deaths were insignificant. The optimal strategies revealed that public education had less of an effect on those who were vulnerable than the vaccine control strategy. However, both approaches were successful in reducing the number of people who were exposed to the illness and reducing the number of fatalities. Vaccination reduced the number by 32.35% and public education by 50% at the peak of the exposed phase. Additionally, vaccination increases a person’s immunity, which speeds up their recovery. Conclusions: A deterministic classical model incorporating optimal controls was proposed to study the monkeypox virus dynamics in a population. The disease is not endemic, which is explained by the model’s basic reproduction number, which was less than unity. Based on the findings of this study, we advise the use of both strategies in controlling the disease.
A framework for doctoral education in developing students’ mental well-being by integrating the demand and resources of the program: An integrative review
Authors: Acharya Vrinda , Rajendran Ambigai , Shenoy Sandeep 
Published: August 2023

Background: Research on doctoral students’ mental well-being has gained importance in recent years. The findings of such studies were uncertain about the critical demand and resource of a doctoral program that largely influence students’ mental health. This review aims to integrate the literature to bring out the nature, importance and relationship between differentiated demands, contextual and personal resource, and doctoral students’ well-being. Methods: An integrative review was conducted based on the five-stage structure of Whittemore and Knafl. The study identified 45 articles published from 2000 onwards following the Joanna Briggs Institute quality evaluation criteria and PRISMA reporting guidelines for selecting eligible articles. Results: The integrative review findings disclose that the differentiated demand of doctoral program were categorized into challenge-hindrance demand. This demand experienced by doctoral students were grouped as ambiguity in doctoral program structure, resource inadequacy, workload, complexity, and responsibility. In addition, institutional support, research supervisory support, and intrinsic motivation were treated as essential resource to mitigate the effects of the demands of the doctoral program. Conclusions: An integrated conceptual model was built exclusively for doctoral programs and suggests that the universities and supervisors design and structure healthy, constructive doctoral programs. As an outcome of the review, differentiated demands, contextual, personal resources at the doctoral education and mental well-being of students are supported by the Transactional Model of Stress and Coping, Conservation of Resources, Causality Orientations Theory and Basic Psychological Need Theory respectively. The current review is an initial attempt to synthesize challenge-hindrance demands and contextual-personal resources in determining the mental well-being of doctoral students.
Case Report: IgG4-related kidney disease complicated by interstitial pneumonia
Authors: Mima Akira , Lee Rina , Murakami Ami , Gotoda Hidemasa , Akai Ryosuke , Lee Shinji 
Published: August 2023

Immunoglobulin G4 (IgG4)-related disease is a systemic inflammatory disorder characterized by tubulointerstitial nephritis with IgG4-positive plasma cell infiltration. We report the case of an 84-year-old male who presented with a history of dyspnea on exertion and cough. The lymph nodes were palpated in the axilla. Urinalysis revealed mild proteinuria and increased levels of NAG and β2-microglobulin. Blood tests showed hyperglobulinemia with a marked elevation of serum IgG4 levels. Chest computed tomography showed bilateral ground-glass and reticular opacities in the lower and peripheral portions of the lungs. Ga-67 scintigraphy showed kidney uptake. The patient was diagnosed with IgG4-related kidney disease based on the renal pathology indicative of typical tubulointerstitial nephritis with extensive IgG4-positive plasma cell infiltration. The patient was treated with prednisolone and showed a prompt response in his clinical condition. The patient achieved normalization of serum IgG4 levels 6 months after the initiation of treatment. Although IgG4-related disease is thought to be potentially associated with organ fibrosis, there are few reports on combination of interstitial pneumonia and IgG4-related kidney disease. Our case report presents a possible pattern of IgG4-related disease.
Case Report: Idiopathic pleuroparenchymal fibroelastosis
Authors: Daboussi Selsabil , Lenda Ben Hmida , Mhamedi Samira , Nouha Boubaker , Aichaouia Chiraz , Ayadi Aida , Moatemri Zied 
Published: August 2023

Background: Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a very rare and a slowly conspicuous progressing chronic lung disease, which usually involves the upper lobes of the lung. This unusual disease, first recognized as a rare idiopathic interstitial pneumonia in 2013, is characterized by dense fibrosis of the visceral pleura and the subjacent lung parenchyma accompanied by elastosis predominating in the subpleural alveolar walls. In the interest of improving our understanding of this uncommon disease, we report a case of IPPFE established by pathology results. Case report: A 73-year-old male patient, smoker, with a medical history of chronic obstructive pulmonary disease, presented since January 2022 with a gradual worsening of dyspnea on exertion and productive cough with weight loss. The chest X-ray detected a thoracic distention. The chest high resolution computed tomography revealed biapical subpleural parenchymatous condensations with tractive bronchiectasis and pleural retraction in the right upper lobe and diffuse bilateral cento-lobular emphysema. A scan-guided trans-parietal lung biopsy showed lung parenchyma tattooed with anthracosic deposits, largely remodeled by fibrous tissue, intermingled with numerous wavy and refractive dyselastotic structures in polarized light. The orcein staining confirmed the presence of excess elastosic fibers within these lesions. All etiological investigations were negative. His lung function studies revealed a reversible obstructive ventilatory disorder. Following a multidisciplinary discussion, the diagnosis of IPPFE was confirmed on the basis of the distribution in the upper lungs on chest computed tomography combined with pathology pattern. Conclusions: This case emphasizes the atypical misleading radiological presentation of IPPFE and the key role of pathological results in establishing the diagnosis. Hence, further studies are needed to improve our understanding of this uncommon disease and to establish clear-cut guidelines for IPPFE diagnosis and management.
Comparison of root end sealing ability of three retrograde filling materials in teeth with root apices resected at 900 using dye penetration method under fluorescent microscope
Authors: Chaudhari Dr. Payal , Chandak Manoj , Patel Dr. Aditya 
Published: August 2023

Background: The main factor contributing to surgical endodontic dissatisfaction is an inadequate seal at the apex. The material used for retrograde filling should prevent contaminants from penetrating periradicular tissue. So the objective of this study was to evaluate and compare the ability of Mineral Trioxide Aggregate (MTA), Zirconomer and bioactive bone cement to seal the root end as retrograde filling material with apices resected at 900 angles using dye penetration method under fluorescent microscope. Methods: 36 extracted teeth samples were cut at Cementoenamel junction horizontally. Following the customary protocols of, cleaning, shaping and obturation with gutta percha and AH Plus sealer, resection of samples was done 3mm at the apical end at 90 degree angle along the long axis of the tooth with the help of diamond disc. A depth of 3mm of root end cavity was made with diamond coated ultrasonic surgical tip. The samples were randomly allocated in 3 groups: Group I: MTA ; Group II : Zirconomer; Group III: Bioactive Bone Cement . Coating of nail varnish was done with the roots except at the tip. Each material was compacted in the retrocavity using small pluggers. All the retrofilled samples were kept in acridine orange for 24 hours, following which cleaning & bucco-lingual sectioning (vertical) was carried out. Confocal laser scanning fluorescent microscope was used for checking the dye penetration in these samples thereby evaluating sealing ability. Results: Group III (Bioactive Bone Cement) had the highest root end sealing ability with mean (1.4 ± 0.51) followed by Group I (MTA) (2.3 ± 0.65) and lastly Group II (Zirconomer) (4.1 ± 0.57) as root end filling material with apices resected at 900 angle using dye penetration method under fluorescent microscopy which were statistically significant. Conclusions: Bioactive Bone cement can be recommended as an acceptable retrograde filling material.
Symptoms trend and challenges in dental practice during delta variance COVID-19 pandemic in Indonesia: Google Trends Analysis
Authors: Hasan Faizul , Mayasari Noor Rohmah , Salamanca Eisner , Dorj Odontuya , Satria Rahmat Dani , Latief Kamaluddin , Sujarwadi Mokh. , Budi Hendrik Setia 
Published: August 2023

Background: The COVID-19 pandemic has grown to be a serious issue on a global scale. Dental care is one of the industries affected by COVID-19. The surveillance utilizing lifetime data, however, is still not clear. The purpose of this study was to use Google Trends (GT) analysis to examine symptom trends and challenges during the COVID-19 outbreak in Indonesia. Methods: Covid-19 cases retrieve from Our World in Data. The cases were collected between 1 April 2021-30 September 2021. The GT was used to discover Indonesian relative search volume (RSVs) covering the timeframe of the first outbreak covid-19 pandemic in Indonesia on 1 March 2020 until 13 February 2022. The duration of the search was chosen to reflect the relative popularity of the keywords "symptoms and dentistry practice challenge-related terms" and "coronavirus". Results: We observed that there was a significant and positive correlation between the COVID-19 daily case using GT RSV data and the COVID-19 case from Our World in Data. The COVID-19 daily case had a strong correlation with search terms related to symptoms (such as fever, sore throat, flu, toothache, and cough), drugs (such as ibuprofen, paracetamol, demacolin, bodrex, and antibiotic), and health management (such as self-isolation and telemedicine). Conclusion: Using GT may be helpful to observe the current symptoms trends as well as its challenge tendencies as a surveillance tool for a continuing pandemic like COVID-19. GT should be considered and used as it has the potential to be a powerful digital epidemiology tool that can provide more insight into disease dynamics.
The total factor productivity growth of health systems in African least developed countries
Authors: Musoke Edward , Lule Yawe Bruno , Ddumba Ssentamu John 
Published: August 2023

Background: Given the several health policy reforms in various countries in the Sustainable Development Goals (SDGs) era, the need for efficient and productive health systems has become of great concern. This is even more urgent in African Least Developed Countries (African LDCs) that need to improve the health of their populations. Thus, the objective of this study is to assess the total factor productivity growth of health systems of 29 African Least Developed Countries for the 2008-2018 period. Methods: The study uses data from the World Bank and the World Health Organization. Using the Data Envelopment Analysis (DEA) Malmquist index, the inputs that were used in the study included domestic general government health expenditure, domestic private health expenditure, external health expenditure and out of pocket health expenditure while the outputs were life expectancy at birth, maternal mortality rate, under five mortality rate, and infant mortality rate. Results: Sixteen African LDCs registered progress in the total factor productivity growth of their health systems while thirteen registered a decline the total factor productivity growth of their health systems. Overall, there was 0.3% average increase in total factor productivity growth of health systems in African LDCs. This was attributed to a 1.2% increase in technical efficiency change and a 0.9% average decrease in the technical change of health systems in African LDCs. Conclusions: African LDCs with less productive health systems are advised to bench mark the policies of African LDCs with productive health systems.
Study protocol for supplementation of single high dose Vitamin D in deficient critically ill children and assessment of their short-term outcome: An open label randomized control trial
Authors: Vagha Keta , Lohiya Sham , Vagha Jayant , Vagha Sunita , Taksande Amar , Chaudhary Richa 
Published: August 2023

Vitamin D is a fat-soluble vitamin and is classically considered to play a major role in bone metabolism and maintaining Calcium and phosphorus equilibrium. With progressing research, other roles of Vitamin D are surfacing. The pleotropic functions of Vitamin D regulate cell proliferation, differentiation, apoptosis, and angiogenesis. In critically ill children, Vitamin D deficiency is associated with poor outcomes in the form of increased PICU stay, increased duration of mechanical ventilation, higher rate of Ventilator Associated Pneumonias, increased incidence of sepsis, higher intensive care scores and increased incidence of end organ dysfunction. With this background, we aim to conduct an open label Randomized Control Trial to study the short-term outcome of Vitamin D deficient critically ill children after supplementation of a single high dose oral Vitamin D. This will be an open label randomized control trial conducted at a tertiary care hospital in central India. Children aged 1 month to 18 years, admitted in the pediatric intensive care unit with Serum Vitamin D level less than 20 ng/dL will be the study group. These children will be randomized into two groups as per the computer-generated randomization. Group A will receive standard treatment protocol with 10,000 IU/Kg to 400,000 IU (maximum) Vitamin D via mouth or nasogastric tube, whereas Group B will receive standard treatment protocol. Urinary calcium-creatinine ratio will be done on day 3 in Group A to check for hypervitaminosis D. The outcome of both the groups will be assessed. All the data will be added to a Microsoft Excel sheet. Results and interpretation will be determined on the basis of the obtained observation. Trial registration: CTRI/2022/10/046556.
Nonlocal contrast calculated by the second order visual mechanisms and its significance in identifying facial emotions
Authors: Babenko Vitaly V. , Yavna Denis V. , Ermakov Pavel N. , Anokhina Polina V. 
Published: August 2023

Background: Previously obtained results indicate that faces are /preattentively/ detected in the visual scene very fast, and information on facial expression is rapidly extracted at the lower levels of the visual system. At the same time different facial attributes make different contributions in facial expression recognition. However, it is known, among the preattentive mechanisms there are none that would be selective for certain facial features, such as eyes or mouth. The aim of our study was to identify a candidate for the role of such a mechanism. Our assumption was that the most informative areas of the image are those characterized by spatial heterogeneity, particularly with nonlocal contrast changes. These areas may be identified /in the human visual system/ by the second-order visual /mechanisms/ filters selective to contrast modulations of brightness gradients. Methods: We developed a software program imitating the operation of these /mechanisms/ filters and finding areas of contrast heterogeneity in the image. Using this program, we extracted areas with maximum, minimum and medium contrast modulation amplitudes from the initial face images, then we used these to make three variants of one and the same face. The faces were demonstrated to the observers along with other objects synthesized the same way. The participants had to identify faces and define facial emotional expressions. Results: It was found that the greater is the contrast modulation amplitude of the areas shaping the face, the more precisely the emotion is identified. Conclusions: The results suggest that areas with a greater increase in nonlocal contrast are more informative in facial images, and the second-order visual /mechanisms/ filters can claim the role of /filters/ elements that detect areas of interest, attract visual attention and are windows through which subsequent levels of visual processing receive valuable information.