bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of the Activity of Early Ankylosing Spondylitis using Radiomics Texture Analysis on STIR
Authors: Shi Zhaojuan , Yang Zhe , Wang Mei , Su Datian , Cheng Juan , Liu Hui , Zheng Hui , Han Jiankui , Li Changqin , Qin Jian 
Published: February 2023

Abstract
Purpose
To evaluate the early activity of ankylosing spondylitis(AS)is very important for clinical decision. Owing to lacking of uniform standard and some other limitations, the methods for it are still difficult to practice by clinicians. The study aimed to explore the value of texture analysis of radiomics based on STIR to evaluate the activity of bone marrow edema of sacroiliac joint in early AS.
Methods
A total of 43 patients with early AS were collected in our hospital, including 30 males and 13 females. According to the ratio of 7:3, all the patients were randomly divided into the training cohort (n = 116) and verification cohort (n = 56). Optimal feature subsets were obtained by the Mann-Whitney U test, the minimum-Redundancy Maximum-Relevancy (mRMR), and then the least absolute shrinkage and selection operator (LASSO) using these texture feature parameters. The optimal feature subset was used to construct the final prediction model, and Radscore was obtained by summing the selected features after being weighted by their coefficients. The effectiveness of Radscore value, SPARCC score and ADC value was evaluated by ROC curve. The correlations between Radscore values and the values of SPARCC score, ADC, BASDAI, ESR, CRP, ASDAS-ESR, ASDAS-CRP were analyzed by the Spearman correlation test.
Results
The eight texture feature subsets were selected to obtain Redscore. In the training cohort, to differentiate early AS sacroiliac joint bone marrow edema between between active and stable group,the AUC values of Radscore, SPARCC score and ADC were 0.81,0.91,0.78, respectively. In the validation cohort, the AUC values of them were 0.87,0.89,0.85. In the two cohorts, there were no significant differences in AUC values between values of Radscore and SPARCC score, ADC (P > 0.05). There was a significant difference in AUC values betweenvalues of SPARCC score and ADC in the training cohort (P < 0.05), without statistical significance in the validation cohort (P > 0.05). The correlations were all low between Radscore values and the values of the ESR, CRP, BASDAI, ASDAS-ESR, ASDAS-CRP (P < 0.05).
Conclusion
Radiomics analysis based on STIR texture analysis has a good prediction for the evaluation of bone marrow edema activity of sacroiliac joint in AS.It can be a new noninvasive and objective evaluation method for AS activity, especially for the invisible lesions.
Single ring isolation is superior to circumferential pulmonary vein isolation plus modified posterior box isolation with a high power of 40-45 W in patients with persistent atrial fibrillation
Authors: Song Yanbin , Xue Sheliang , Li Wenhua , Xu Bo , Xiao Jianqiang 
Published: February 2023

Abstract
This study aimed to evaluate the superiority of single ring isolation (SRI) over circumferential pulmonary vein isolation (CPVI) plus modified posterior box isolation (MPOBI) using a high power of 40-45 W in patients with persistent atrial fibrillation (PeAF). We retrospectively studied 77 PeAF patients who underwent primary radiofrequency catheter ablation (RFCA). They were divided into the SRI group and the CPVI+MPOBI group according to the RFCA methods. Basic characteristics, procedural variables and AF recurrence rates at 3 months postprocedure were collected and compared between the two groups after propensity score matching (PSM) for age and left atrial diameter. After PSM, 28 patients in the SRI group were matched with 28 individuals in the CPVI+MPOBI group. Compared with the CPVI+MPOBI group, the total procedure time in the SRI group was not significantly shorter ( P =0.928). The total ablation time and ablation time of the PVs and posterior left atrium (ring ablation time) of patients with SRI were significantly shorter than those of patients with CPVI+MPOBI (all P <0.001). The total ablation spots and initial ring spots in the SRI group were significantly fewer than those in the CPVI+MPOBI group (all P <0.001), but the total additional spots were not different between the two groups (P=0.060). The proportion of immediate sinus rhythm was significantly higher in patients with SRI than in those with CPVI+MPOBI (P<0.001). At the follow-up analysis, the AF recurrence rate did not significantly differ between the SRI and CPVI+ MPOBI groups (14.3% vs. 17.9%, P=0.716). In conclusion, this study demonstrated that SRI with a high power was safe and effective for patients with PeAF, and it was superior to CPVI+MPOBI.
Determinants of the capacity of dryland ecosystems to store soil carbon under altered fire regimes
Authors: Pellegrini Adam , Reich Peter B , Hobbie Sarah , Coetsee Corli , Wigley Benjamin , February Edmund , Georgiou Katerina , Terrer César , Brookshire E.N. , Ahlström Anders , Nieradzik Lars , Sitch Stephen , Melton Joe , Forrest Matthew , Li Fang , Hantson Stijn , Burton Chantelle , Yue Chao , Ciais Philippe , Jackson Robert 
Published: February 2023

Abstract
Widespread changes in the intensity and frequency of fires across the globe are altering the terrestrial carbon (C) sink1–4. Although the changes in ecosystem C have been reasonably well quantified for plant biomass pools5–7, an understanding of the determinants of fire-driven changes in soil organic C (SOC) across broad environmental gradients remains unclear, especially in global drylands3,4,7–9. Here, we combined multiple datasets and original field sampling of fire manipulation experiments to evaluate where and why fire changes SOC the most, built a statistical model to estimate historical changes in SOC, and compared these estimates to simulations from ecosystem models. We found that drier ecosystems experienced larger relative changes in SOC than humid ecosystems—in some cases exceeding losses from plant biomass pools—primarily explained by high fire-driven declines in tree biomass inputs in dry ecosystems. Ecosystem models provided more mixed insight into potential SOC changes because many models underestimated the SOC changes in drier ecosystems. Upscaling our statistical model predicted that soils in 1.57 million km2 savanna-grassland regions experiencing declines in burned area over the past ca. two decades may have 23% more SOC, equating to 1.78 PgC in topsoils. Consequently, ongoing declines in fire frequencies have likely created an extensive carbon sink in the soils of global drylands that may have been underestimated by ecosystem models.
The clinical impact of Lumacaftor-Ivacaftor on structural lung disease and lung function in children aged 6-11 with Cystic Fibrosis in a real-world setting
Authors: McNally Paul , Linnane Barry , Williamson Michael , Elnazir Basil , Short Christopher , Saunders Claire , Kirwan Laura , Vandercorput Mariette , Tiddens H.A.W.M , Davies JC , Cox DW 
Published: February 2023

Abstract
Background:
Data from clinical trials of lumacaftor-ivacaftor (LUM-IVA) demonstrate improvements in lung clearance index (LCI) but not in FEV1 in children with Cystic Fibrosis (CF) aged 6-11 years and homozygous for the Phe508del mutation. It is not known whether LUM/IVA use in children can impact the progression of structural lung disease. We sought to determine the real-world impact of LUM/IVA on lung structure and function in children aged 6-11 years.
Methods:
This real-world observational cohort study was conducted across four paediatric sites in Ireland over 24-months using spirometry-controlled CT scores and LCI as primary outcome measures. Children commencing LUM-/IVA as part of routine care were included. CT scans were manually scored with the PRAGMA CF scoring system and analysed using the automated airway-artery (AA) method. Secondary outcome measures included rate of change of ppFEV1, nutritional indices and exacerbations requiring hospitalisation.
Results:
Seventy-one participants were recruited to the study, 31 of whom had spirometry-controlled CT performed at baseline, and after one year and two years of LUM/IVA treatment. At two years there was a reduction from baseline in trapped air scores (0.13 to 0.07, p=0.016), but an increase from baseline in the % bronchiectasis score (0.84 to 1.23, p=0.007). There was no change in overall % disease score (2.78 to 2.25, p=0.138). Airway lumen to pulmonary artery ratios (AlumenA ratio) were abnormal at baseline and worsened over the course of the study. In 28 participants, the mean annual change from baseline LCI2.5 (-0.055 (-0.61 to 0.50), p=0.85) measurements over two years were not significant. Improvements from baseline in weight (0.10 (0.06 to 0.15, p<0.0001), height (0.05 (0.02 to 0.09), p=0.002) and BMI (0.09 (0.03 to 0.15) p=0.005) z-scores were seen with LUM/IVA treatment. The mean annual change from baseline ppFEV1 (-2.45 (-4.44 to 2.54), p=0.66) measurements over two years were not significant.
Conclusion:
In a real-world setting, the use of LUM/IVA over two years in children with CF aged 6-11 resulted in improvements in air trapping on CT but worsening in bronchiectasis scores. Our results suggest that LUM/IVA use in this age group improves air trapping but does not prevent progression of bronchiectasis over two years of treatment.
Formant-Aware Spectral Analysis of Sustained Vowels of Pathological Breathy Voice
Authors: Ikuma Takeshi , McWhorter Andrew J. , Oral Evrim , Kunduk Melda 
Published: February 2023

Abstract
Objectives. This paper reports the effectiveness of formant-aware spectral parameters to predict the perceptual breathiness rating. Breathy voice has a higher first harmonic, steeper spectral slope, and higher turbulent noise than normal voice. Measuring spectral parameters of acoustic signal over formant regions is a known approach to capture the properties related to breathiness. This study examines this approach by testing the contemporary spectral parameters and algorithms within the framework, alternate frequency band designs, and vowel effects.
Methods.Sustained vowel recordings (/a/, /i/, and /u/) of speakers with voice disorders in the German Saarbrueken Voice Database were considered (n=368). Recordings with spectral irregularity or roughness perception were excluded from the study. Four speech language pathologists perceptually rated the recordings for breathiness on a 100-point scale, and their averages were used as the ratings of the recordings. The acoustic spectra were segmented into four frequency bands according to the vowel formant structures. Five different spectral parameters were considered in each band or between bands (13 total plus the fundamental frequency) to predict the perceptual breathiness rating.
Results. Linear combinations of spectral parameters, led by the formant-focused harmonics-to-noise ratios (HNRs), were shown to explain up to 85% of the variance in perceptual breathiness ratings of disordered voice. This performance exceeded that of the Acoustic Breathiness Index (82%). Also, the best performing parameter (the HNR over the first two formants, 78%) explained more variances in the breathiness than the smoothed cepstrum peak prominence (74%). Some vowel effects were observed in the perceptual rating (higher for /u/), in predictability (5% lower for /u/), and in model parameter selections.
Conclusions.Strong breathiness correlates were found by segmenting the spectrum to isolate the portion most affected by breathiness.
Prediction of mammalian tissue-specific CLOCK-BMAL1 binding to E-box motifs
Authors: Marri Daniel , Filipovic David , Kana Omar , Tischkau Shelley , Bhattacharya Sudin 
Published: February 2023

Abstract
Motivation: The Brain and Muscle ARNTL-Like 1 protein (BMAL1) forms a heterodimer with either Circadian Locomotor Output Cycles Kaput (CLOCK) or Neuronal PAS domain protein 2 (NPAS2) to act as a master regulator of the mammalian circadian clock gene network. The dimer binds to E-box gene regulatory elements, activating downstream transcription of clock genes. Identification of transcription factor binding sites and features that correlate to DNA binding by BMAL1 is a challenging problem, given that CLOCK-BMAL1 or NPAS2-BMAL1 bind to several distinct binding motifs (CANNTG) on DNA.
Results: Using three different types of tissue-specific machine learning models with features based on 1) DNA sequence, 2) DNA sequence plus DNA shape, and 3) DNA sequence and shape plus histone modifications, we developed an interpretable predictive model of genome-wide BMAL1 binding to E-box motifs and dissected the mechanisms underlying BMAL1-DNA binding. Our results indicated that histone modifications, the local shape of the DNA, and the flanking sequence of the E-box motif are sufficient predictive features for BMAL1-DNA binding. Our models also provide mechanistic insights into tissue specificity of DNA binding by BMAL1.
BIM Interoperability in the Maintenance Planning Process for Existing Buildings
Authors: Inojosa Leonardo da Silveira Pirillo , Vilanova Kinderman de Araújo 
Published: February 2023

Abstract
One of the main difficulties inherent to the process of maintenance and management of existing assets is the lack of plans and project documents that allow a study and even an understanding of how the structure of the building works, in addition to the lack of records of the changes made that may have altered the structure of the heritage building over time. This makes it difficult to analyze interventions to treat possible problems that may evolve to more worrying pathologies and that put at risk the useful life of the property. Older buildings require more frequent inspections to carry out interventions that can extend their service life. Having all records of maintenance and inspections carried out is essential for better planning of future interventions. This work aims to develop a workflow methodology to facilitate the process of maintenance and management of existing buildings, uniting facility management concepts and using BIM interoperability, through IFC (Industry Foundation Classes), integrated with online forms for collection and documentation of visual inspection data of the structure. To perform this dialogue, the Software Navisworks Manage 2022 was used for the visualization and documentation of the 3D model referring to the as-built of the SG-12, part of the set of General Services Sheds of the University of Brasília, which besides being an old building and being in the process of being listed as cultural heritage, has undergone several changes over time. The methodology developed and the result of the documentation of the data are presented in detail.
Smart Plug Hub: A Sensor Fusion-Based Approach to Non-Invasive Activities of Daily Living Estimation
Authors: Kang Ho-Min , Lee Cheolhwan , Kang Soon-Ju 
Published: February 2023

Abstract
This paper presents Smart Plug Hub (SPH), a non-invasive system for accurately estimating a patient's Activities of Daily Living (ADL). Traditional methods for measuring ADL include interviews, remote video systems, and behavior-tracking wearable devices. However, these approaches have limitations, such as patient memory dependency, privacy violations, and device management issues. To overcome these limitations, SPH utilizes sensor fusion to analyze time-series environmental signals and accurately estimate a patient's ADL. We also efficiently utilized computing resources by implementing "device collaboration" in SPH to receive event data and segment a portion of the time-series environmental signal. By segmenting the data into small segments, we extracted an analyzable dataset, which was processed by an edge device. We conducted several experiments with SPH and successfully classified a patient's ADL by visualizing different activities. This study proposes an effective approach to analyzing both emergency situations and ADL, which is critical for accurate clinical decision-making.
Comparison of laparoscopic Nissen and Dor fundoplication for gastroesophageal reflux disease and paraesophageal hernia: A case-control study
Authors: Zhang Liang , Xinxin Yang , Hui Yang , Jianqiang Huang , Tao You , Xiangyang Xue , Xiaowu Xu , Yue Qu , Yingpeng Huang 
Published: February 2023

Abstract
Purpose
This case-control study aims to compare the different safety and efficacy of laparoscopic Nissen (LNF) and Dor (LDF) fundoplication totally from a patient-subjective view.
Methods
One hundred patients receiving laparoscopic anti-reflux surgery (LARS), either LNF or LDF to manage clinically diagnosed GERD & PEH between January 2018 and December 2021 were recruited. Patient outcomes were evaluated at the three-month follow up visit using GERD symptom questionnaire (GERD-Q), a dysphagia Likert scale, and GERD-Health Related Quality of Life (GERD-HRQL) questionnaire.
Results
Seventy-nine patients met the selection criteria. Twenty-one underwent LNF and fifty-eight received LDF. There was no significant difference in age, gender, preoperative BMI, surgical duration, bleeding volume, meshes replacement and postoperative hospital stays between these two groups (P > 0.05). The relief of GERD symptoms were achieved in patients receiving either LNF or LDF. Although LNF appeared to be better in controlling nausea, patients treated with LNF was more likely to suffer postoperative dysphagia than those receiving LDF (P = 0.035). Interestingly, HRQL assessment suggested that a higher percentage of LNF patients were unsatisfied with the treatment outcome relative to the LDF group, although the difference was marginal (28.57% versus 5.17%, P = 0.096).
Conclusion
Our patient-oriented comparisons suggested that LNF and LDF were both effective and safe for managing GERD & PEH. LNF appeared to cause less nausea in patients, while LDF was associated with fewer severe postoperative dysphagia cases and higher satisfaction of patients.
Short-term outcomes and cost-effectiveness between long-course chemoradiation and short-course radiotherapy followed by consolidation chemotherapy for the treatment of locally advanced rectal cancer
Authors: Cho Min Soo , Bae Hyeon Woo , Chang Jee Suk , Yang Seung Yoon , Kim Tae Hyun , Koom Woong Sub , Shin Sang Jun , Choi Gyu-Seog , Kim Nam Kyu 
Published: February 2023

Abstract
Background: Long-course chemoradiotherapy (LCRT) has been widely recommended in a majority of rectal cancer patients. Recently, encouraging data on short-course radiotherapy (SCRT) for rectal cancer has emergedWe aimed to compare these two methods in terms of short-term outcomes and cost analysis under Korean medical insurance system.
Materials and methods: 62 patients with high-risk rectal cancer underwent either SCRT or LCRT followed by total mesorectal excision (TME) and classified into two groups. Twenty-seven patients received 5 Gy × 5 with two cycles of XELOX (capecitabine 1,000 mg/m2 and oxaliplatin 130 mg/m2 every 3 weeks) followed by TME (SCRT group). Thirty-five patients received capecitabine-based LCRT followed by TME (LCRT group). Short-term outcomes and cost estimation was assessed between the two groups.
Result: Pathological complete response was achieved in 18.5% and 5.7% of patients in the SCRT and LCRT groups, respectively (p = 0.223). The 2-year recurrence-free survival rate did not show significant difference between the groups (SCRT vs. LCRT: 91.9% vs. 76.2%, p = 0.394). The average total cost per patient for SCRT was 18% lower for inpatient treatment (SCRT vs. LCRT: $18,787 vs. $22,203, p < 0.001) and 40% lower for outpatient treatment (SCRT vs. LCRT: $11,955 vs. $19,641, p < 0.001) compared to LCRT. SCRT has been shown to be the dominant treatment option with fewer recurrences and fewer complications at a lower cost.
Conclusion: SCRT was well-tolerated and achieved favorable short-term outcomes. In addition, SCRT showed significant reduction of total cost of care and distinguished cost-effectiveness compared to LCRT.
A Cross-View Geo-localization Method Guided By Relation-Aware Global Attention
Authors: Sun Jing , Yan Rui , Zhang Bing , Zhu Bing , Sun Fuming 
Published: February 2023

Abstract
Cross-view geo-localization mainly exploits query images to match images from the same geographical location from different platforms. Most existing methods fail to adequately consider the effect of image structural information on cross-view geo-localization, resulting in the extracted features can not fully characterize the image, which affects the localization accuracy. Based on this, this paper proposes a cross-view geo-localization method guided by relation-aware global attention, which can capture the rich global structural information by perfectly integrating attention mechanism and feature extraction network, thus improving the representation ability of features. Meanwhile, considering the important role of semantic and context information in geo-localization, a joint training structure with parallel global branch and local branch is designed to fully mine multi-scale context features for image matching, which can further improve the accuracy of cross-view geo-localization. The quantitative and qualitative experimental results on University-1652, CVUSA, and CVACT datasets show that the algorithm in this paper outperforms other advanced methods in recall accuracy (Recall) and image retrieval average precision (AP).
Studies on the Origin of Asian Cultivated Rice Based on 15 Domestication Region
Authors: sun Tingting 
Published: February 2023

Abstract
Cultivated rice (Oryza sativa L.) is an important food crop in the world, and its domestication is one of the important historical developments. In this study, we found 15 domesticated fragments in all of them and their nucleotide diversity by analyzing 461 wild rice and 595 cultivated rice accessions. The 15 domesticated fragments were then individually phylogenetic tree constructed to analyze the most recent wild population for each branch. We identify wild populations in southern China and the India as the source of the temperate japonica and tropical japonica gene pool. In addition, wild populations in Southeast Asia, China and India as the source of the indica gene pool. Interesting, wild populations in India and Burma as the source of the Aus and Bas gene pool, respectively.