bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are school-based interventions promoting 24-hour movement guidelines among children? A scoping review
Authors: Rodrigo-Sanjoaquín Javier , Bois Julien E , Aibar Solana Alberto , Lhuisset Léna , Corral-Abós Ana , Zaragoza Casterad Javier 
Published: April 2023

Objective: 24-hour movement behaviours can effect sustainable long-term benefits in children, but their implementation and effectiveness have not previously been reviewed in the school setting. Thus, the aim of this scoping review was to provide an overview of school-based interventions targeting physical activity (PA), sedentary behaviour (SB), and sleep in 5–12-year-old children. Design: Scoping review. Methods: A structured bibliographic search of five databases was conducted to retrieve peer-reviewed intervention studies published in English language, between January 2010 and December 2020. Results: Among the 37 studies included with a total sample size of 27,145 primary school-aged children, only one study assessed sleep, PA and SB. The average duration of the intervention studies was between 7 and 10 months. Conclusion: The main gap identified was that current school-based interventions do not include complete 24-hour movement behaviours among children as there is a lack of intervention studies addressing sleep behaviour. In addition, this first international review of 24-hour movement behaviours in a school setting found that the number of intervention studies that incuded follow-up measures is limited, so it is difficult to interpret their sustainability.
Improvements in psychological distress in patients participating in a cooking programme following digestive cancer surgery: A retrospective, propensity score-matched pilot study
Authors: Kondo Ken , Kim Siyeong , Noguchi Naoto , Akiyama Ryoto , Murata Waka , Lee Bumsuk 
Published: April 2023

Introduction: This retrospective pilot study evaluated whether an Instrumental Activities of Daily Living intervention relieves psychological distress during hospital stays after digestive cancer surgery. Methods: In all, 24 patients were divided into two groups according to the experience of cooking programme during hospital stay (‘control group’, n = 11 and ‘cooking group’, n = 13) and both groups received usual postoperative care. The two groups were matched using propensity scores to reduce the potential for confounding factors. Outcome measures included psychological distress assessed by the Hospital Anxiety and Depression Scale and Basic Activities of Daily Living assessed by the Functional Independence Measure. Assessment time points were after surgical treatment and before discharge. Results: Propensity score matching generated nine pairs (‘control group’, n = 9 and ‘cooking group’, n = 9). The Functional Independence Measure improved in both groups ( p = 0.008, r = 0.89) and the improvements in the Hospital Anxiety and Depression Scale were only found in the cooking group ( p ⩽ 0.049, r ⩾ 0.66). Conclusion: We found significant improvement in Basic Activities of Daily Livings in both groups and additional improvements in psychological distress in the cooking group. These observations suggest that Instrumental Activities of Daily Living-based intervention could improve mental health in patients with cancer in their early postoperative period.
Psychosocial Functioning and Health-Related Quality of Life in Children with Nephrotic Syndrome: Preliminary Findings
Authors: Aier Alemsungla , Pais Priya , Raman Vijaya 
Published: April 2023

Background: Nephrotic syndrome (NS) is one of the most commonly diagnosed kidney diseases in childhood, with a high relapse rate. Aim: This study was designed to assess emotional and behavioural problems, temperament, family environment, and evaluate the health-related quality of life in children with NS. Methods: This cross-sectional study was conducted at a tertiary care hospital in South India. A purposive sampling technique was used. A sample of 32 children between ages 6 and 12 years with NS—steroid-sensitive (infrequent relapsers, frequent relapsers, or those with steroid-dependent) and steroid-resistant—for more than 6 months duration and managed by the Pediatric Nephrology department were recruited. The control group of 30 healthy children was matched for age and gender. The assessment was conducted using the Strengths and Difficulties Questionnaire (SDQ), Pediatric Quality of Life Inventory™ (PedsQL 4.0), Malhotra Temperament Schedule, and Family Environment Scale. Data obtained was examined using descriptive and inferential statistics. Results: On the SDQ, 34.4% of children with NS indicated a total score within the clinical range. Children with NS had an overall lower score on the QOL scale ( P < .003). It was found that the SRNS subtype had poor scores on SDQ ( P < .023) and QOL ( P < .017). The temperament of children with NS did not differ from those of healthy children. The families with NS scored lower on organization ( P < .042) and control ( P < .006) subscales. Conclusion: Children with NS have a risk of emotional and behavioural problems. It appears that children with NS have a poor quality of life. Families of children with NS were less organized and low in control. Findings indicate the need for routine psychological evaluation and intervention as they will impact the course and outcome of NS.
The Lived Experience of Middle-Aged Saudi Patients With End-Stage Chronic Renal Disease on Hemodialysis Treatment
Authors: Alzahrani Naif S. , Almarwani Abdulaziz Mofdy , Alhowaymel Fahad , Alharbi Hanan F. 
Published: April 2023

Introduction: More than 20,000 patients with chronic renal disease are receiving hemodialysis treatment in Saudi Arabia. Approximately, 57.4% of nurses in Saudi are expatriates. However, these nurses may not have sufficient cultural knowledge, which may affect perception of nursing care. Our purpose was to understand the lived experiences of middle-aged Saudi Arabian hemodialysis patients. Method: This qualitative phenomenological study was conducted in Saudi Arabia in 2021. Data were analyzed using axial coding. Results: Eleven patients aged 32 to 60 years participated. Two themes and three subthemes were identified: (a) hemodialysis’s negative consequences (travel restriction, social isolation, and low responsibilities toward families) and (b) level of support (family support, nurses’ support, and governmental support). Discussion: Hemodialysis patients find travel and social engagement difficult. Furthermore, they cannot fully meet their family responsibilities due to fatigue and long hemodialysis hours. Health care providers should consider integrating these findings to deliver optimal holistic care.
Biokinetic Evaluation of Hallux Valgus during Gait: A Systematic Review
Authors: Rosemberg Dov Lagus , Gustafson Jonathan A. , Bordignon Glaucia , Bohl Daniel D. , Leporace Gustavo , Metsavaht Leonardo 
Published: April 2023

Background: Foot pathologies can affect the kinetic chain during gait, leading to altered loading at other joints that can lead to subsequent pathologies. Although hallux valgus is the most common foot disease, little has been discussed about the biokinetic effects of hallux valgus on the foot and lower limb. This systematic review evaluated the kinematic, kinetic, and pedobarographic changes of the hallux valgus foot compared to a healthy one. Methods: Several electronic databases were searched up to January 2022, including only cross-sectional studies with clearly defined isolated hallux valgus diseases and healthy groups. Two investigators independently rated studies for methodological quality using the NIH Study Quality Assessment Tool for cross-sectional studies. Kinetic data were extracted, including temporal data, kinematics of the foot joint, kinematics of the proximal lower limb, and pedobarography. We did meta-analyses tests with a random effects model using the metafor package in R. Results: Hallux valgus patients walk slower compared to a disease-free control group −0.16 m/s (95% CI −0.27, −0.05). Hallux valgus patients exhibited significantly reduced coronal plane motion of the hindfoot-shank during preswing 1.16 degrees (95% CI 0.31, 2.00). Hallux valgus patients generated less force in the hallux region 33.48 N (95% CI 8.62, 58.35) but similar peak pressures in the hallux compared to controls. Hallux valgus patients generated less peak pressure at the medial and lateral hindfoot as compared to controls: 8.28 kPa (95% CI 2.92, 13.64) and 8.54 kPa (95% CI 3.55, 13.52), respectively. Conclusion: Although hallux valgus is a deformity of the forefoot, the kinematic changes due to the pathology are associated with significant changes in the range of motion at other joints, underscoring its importance in the kinetic chain. This is demonstrated again with the changes of peak pressure. Nevertheless, more high-quality studies are still needed to develop a fuller understanding of this pathology.
Arts and culture engagement and mortality: A population-based prospective cohort study
Authors: Jensen Anita , Pirouzifard Mirnabi , Lindström Martin 
Published: April 2023

Aims: The aim of this study was to investigate associations between having visited the theatre/cinema and an arts exhibition during the past year and all-cause, cardiovascular disease (CVD), cancer and other-cause mortality. Methods: The 2008 public health postal survey in Scania, Sweden, was distributed to a stratified random sample of the adult population (18–80 years old). The participation rate was 54.1%, and 25,420 participants were included in the present study. The baseline 2008 survey data were linked to cause-of-death register data to create a prospective cohort with 8.3-year follow-up. Associations between visit to the theatre/cinema, visit to an arts exhibition and mortality were investigated in survival (Cox) regression models. Results: Just over a quarter (26.5%) had visited both the theatre/cinema and an arts exhibition during the past year, 36.6% only the theatre/cinema, 4.9% only an arts exhibition and 32% neither of the two. Not visiting the theatre/cinema during the past year was associated with higher all-cause and CVD mortality. Not visiting an arts exhibition was associated with higher all-cause and other-cause mortality. The combination of having visited neither the theatre/cinema nor an arts exhibition during the past year was associated with higher all-cause, CVD and other-cause mortality. Conclusions: There is an association between attending arts and culture activities and a reduced risk of CVD and other-cause mortality but not cancer mortality, although model imperfections are possible.
Sickness absence among migrant and non-migrant care workers in Finland: A register-based follow-up study
Authors: Olakivi Antero , Kouvonen Anne , Koskinen Aki , Kemppainen Laura , Kokkinen Lauri , Väänänen Ari 
Published: April 2023

Aims: This study aimed to compare the sickness absence (SA; over 10 days) rates of migrant and non-migrant care workers in Finland. Methods: Two cohorts were randomly sampled from nationwide registers and analysed together in a three-year follow-up design (2011–2013, 2014–2016). The pooled data consisted of 78,476 care workers, of whom 5% had a migrant background. Statistical methods included cross-tabulations and Poisson regression modelling. Results: Thirty-five percent of the Finnish-born care workers had at least one SA during the follow-up. Care workers from the post-2004 EU countries (30%, at least one SA), Russia, the Former Soviet Union and the Balkan states (25%) and the Global South and East (21%) had fewer episodes of SA than the Finnish-born care workers. The two latter groups also had lower SA rates after we controlled for occupation, gender, age, income and region of residence. Care workers from Western Europe and the Global North (36%) had higher SA rates than the Finnish-born care workers. Conclusions: The following explanations were discussed: population-level health differences – migrants from lower-income non-EU countries are generally healthier than the Finnish-born population (due to, e.g., the ‘healthy migrant effect’); discrimination in recruitment and employment – migrants from lower-income non-EU countries need to be healthier than Finnish-born jobseekers to gain employment (in the care sector or more broadly); and sickness presenteeism – migrants from lower-income non-EU countries underuse their right to sickness allowance (due to, e.g., job insecurity). It is likely that these mechanisms affect migrants differently depending on, for example, their countries of origin and social status in Finland.
Relationship Between Caffeine Consumption and Young Athletes’ Comorbidities, Exercise-Related Symptoms, and Baseline Electrocardiogram
Authors: Farber Jason , Dikdan Sean , Ruge Max , Johnson Drew , Shipon David 
Published: April 2023

Background: Caffeine consumption causes diverse physiologic effects that can affect athletes both positively and negatively. There is a lack of research investigating the long-term effects of caffeine intake on exercise and on overall cardiovascular health in young athletes. Hypothesis: Certain characteristics such as age, body mass index (BMI), race, and medical diagnoses are associated with increased caffeine use, and there is a relationship between caffeine consumption and symptoms during exercise and cardiovascular abnormalities in young athletes. Study Design: Cross-sectional study. Level of Evidence: Level 4. Methods: This study utilized the HeartBytes National Youth Cardiac Registry to collect data related to demographics, caffeine use, and physical examination and electrocardiogram (ECG) findings of 7425 12- to 20-year-olds (60.6% male, 39.4% female) who attended a Simon’s Heart cardiac screening event between 2014 and 2021. Univariable and multivariable logistic regression models were used for analysis. Results: Persons who consumed caffeine were more likely to have attention deficit hyperactivity disorder (ADHD) (adjusted odds ratio [aOR], 1.43; CI, 1.15-1.76]; P < 0.01) and more likely to have a BMI ≥30 kg/m2 (aOR, 1.69; CI, 1.27-2.25]; P < 0.01) compared with nondrinkers. After controlling for age, gender, race, and BMI, there were no significant differences in symptoms during exercise (aOR, 1.27; CI, 0.97-1.66; P = 0.08) or abnormal ECG findings (OR, 0.93; CI, 0.66-1.31; P = 0.70) between those who consume caffeine and those who do not. Conclusion: Caffeine consumption was associated with increased BMI and increased likelihood of having ADHD; however, caffeine use overall was not associated with increased risk of symptoms during exercise or ECG abnormalities. Clinical Relevance: Whereas caffeine consumption overall did not increase risk of exercise-related symptoms, soda drinkers were at higher risk for symptoms during exercise, and coffee drinkers were at higher risk of syncope with exercise. Prospective studies with longitudinal follow-up and more specific outcomes data is the next step in qualifying the impact of caffeine on young athletes.
Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis
Authors: Wu Xiaoxin , Sun Antonia RuJia , Crawford Ross , Xiao Yin , Wang Yanping , Prasadam Indira , Mao Xinzhan 
Published: April 2023

Objective Chronic inflammation plays an important role in the osteoarthritis (OA) pathology but how this influence OA disease progression is unclear. Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator generated from arachidonic acid through the sequential activities of 5-lipoxygenase, 5-lipoxygenase–activating protein, Leukotriene A4 hydrolase (LTA4H) and its downstream product LTB4. The aim of this study is to investigate the involvement and the potential therapeutic target of the LTB4 pathway in OA disease progression. Design Both clinical human cartilage samples ( n = 7) and mice experimental OA models ( n = 6) were used. The levels of LTA4H and leukotriene B4 receptor 1 were first examined using immunostaining in human OA/non-OA cartilage and mice experimental OA models. We also determined whether the LTA4H pathway was associated with cartilage degeneration and synovitis inflammation in OA mice models and human articular chondrocytes. Results We found that both LTA4H and LTB4 receptor (BLT1) were highly expressed in human and mice OA cartilage. Inhibition of LTA4H suppressed cartilage degeneration and synovitis in OA mice model. Furthermore, inhibition of LTA4H promoted cartilage regeneration by upregulating chondrogenic genes expression such as aggrecan ( ACAN), collagen 2A1 ( COL2A1), and SRY-Box transcription factor 9 ( SOX9). Conclusions Our results indicate that the LTA4H pathway is a crucial regulator of OA pathogenesis and suggest that LTA4H could be a therapeutic target in combat OA.
Efficacy and safety of damoctocog alfa pegol prophylaxis in patients ⩾40 years with severe haemophilia A and comorbidities: post hoc analysis from the PROTECT VIII study
Authors: Reding Mark T. , Pabinger Ingrid , Holme Pål Andrè , Maas Enriquez Monika , Mancuso Maria Elisa , Lalezari Shadan , Miesbach Wolfgang , Di Minno Giovanni , Klamroth Robert , Hermans Cedric 
Published: April 2023

Background: Advances in treatment have enabled patients with haemophilia A to live longer and therefore may be subjected to comorbidities associated with ageing, in addition to disease-associated morbidities. There have been few reports to date on efficacy and safety of treatment specifically in patients with severe haemophilia A and comorbidities. Objective: To explore the efficacy and safety of damoctocog alfa pegol prophylaxis in patients with severe haemophilia A aged ⩾40 years with comorbidities of interest. Design: A post hoc analysis of data from the phase 2/3 PROTECT VIII study and its extension. Methods: Bleeding and safety outcomes were analysed in a subgroup of patients aged ⩾40 years with ⩾1 comorbidity receiving damoctocog alfa pegol (BAY 94-9027; Jivi®) prophylaxis. Results: Thirty-four patients with severe haemophilia A were included in this analysis, with a mean age of 49.4 years at time of enrolment. The most prevalent comorbidities were hepatitis C ( n = 33; chronic, n = 23), hepatitis B ( n = 8) and hypertension ( n = 11). Four patients had human immunodeficiency virus. All received damoctocog alfa pegol prophylaxis for the entire study [median (range) time in study = 3.9 (1.0–6.9) years]. During the main study and extension, median total annualised bleeding rates (ABRs) (Q1; Q3) were 2.1 (0.0; 5.8) and 2.2 (0.6; 6.0), respectively; median joint ABRs were 1.9 (0.0; 4.4) and 1.6 (0.0; 4.0), respectively. Mean adherence with prophylaxis schedule was greater than 95% throughout the study. No deaths or thrombotic events were reported. Conclusion: Efficacy, safety and adherence of damoctocog alfa pegol were confirmed in patients aged ⩾40 years with haemophilia A and one or more comorbidities, with data for up to 7 years supporting its use as a long-term treatment option in this group.
An Introspective Analysis of Inclusive Growth in Africa, With an Eminence on the Influence of Governance and Financial Development Interaction
Authors: Li Kaodui , Nketia Easmond Baah , Kong Yusheng , Appiah Michael 
Published: April 2023

The study considered the relationship between the interaction of financial development with all six distinct governance indicators from the world development indicators, as well as a combination of them, and inclusive growth in 48 African economies from 2000 to 2019. The countries were classified into low-income countries and middle-income countries. The models were then estimated with Panel Quantile Regression with Fixed Effects estimations, and Dumitrescu & Hurlin causality tests after going through robust econometric tests. From the outcome, the interaction of financial development with corruption control is essential for inclusive growth in only middle-income countries. The interaction of financial development with political stability and the absence of violence/terrorism, and the interaction of financial development and governance in general are relevant to inclusive growth in Africa as a whole and middle-income countries. However, the interaction of financial development with voice and accountability, and the interaction of financial development with rule of law are relevant to inclusive growth in all country groupings. JEL: G20; F62; R50
Effects of home-based manual dexterity training on cognitive function among older adults: a randomized controlled trial
Authors: Seol Jaehoon , Lim Namhoon , Nagata Koki , Okura Tomohiro 
Published: April 2023

Abstract
Background
The relationship between manual dexterity and cognitive function among older adults is well known; however, few studies have focused on manual dexterity training that confirms cognitive load of training in older adults through functional near-infrared spectroscopy (fNIRS) and verifies the effect of training. This study examined the effects of home-based manual dexterity training on cognitive function in older adults using a digital trail-making peg test device combining two conventional assessment tools namely, the peg and trail-making tests.

Methods
For 12 weeks, 57 healthy older adults aged 65–88 years participated in a parallel-group, randomized controlled trial, wherein home-based manual dexterity training was performed for approximately 20 min daily. To quantify the cognitive load in different manual dexterity conditions, we assessed the cortical activation patterns of the prefrontal cortex via a wearable four-channel fNIRS device. Participants in the control group were asked to continue their usual daily routines during the intervention period. Cognitive function was assessed using the Stroop Color and Word and Cognitive Impairment Tests. Manual dexterity was assessed using the Purdue Pegboard Test. All outcomes were estimated before and after the intervention.

Results
We observed significant differences in prefrontal cortical activation between the different manual dexterity conditions. Only the intervention group showed a significant improvement in Stroop interference (169.0–108.9 ms, p = 0.032) and an executive function and assembly task of the Purdue Pegboard Test (22.5–26.4 counts, p < 0.001). Additionally, except the clock drawing task, cognitive function had a larger effect size (Cohen’s d) in the intervention group (d = 0.26–0.45) than in the control group (d = 0.11–0.28).

Conclusions
Home-based manual dexterity training can improve performance in a complex manual dexterity task and executive functioning in older adults.

Trial registration
UMIN-CTR Clinical Trial, UMIN000047203. Registered 17 March 2022 – Retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000053844&type=summary&language=E