bluuebunny/crossref_metadata_2025_split huggingface dataset:
PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling
Authors: Raja Remya , Wu Christopher , Bassoy Esen Yonca , Rubino Thomas E , Utagawa Emma C , Magtibay Paul M , Butler Kristina A , Curtis Marion 
Published: December 2022

BackgroundIncreased infiltration of T cells into ovarian tumors has been repeatedly shown to be predictive of enhanced patient survival. However, despite the evidence of an active immune response in ovarian cancer (OC), the frequency of responses to immune checkpoint blockade (ICB) therapy in OC is much lower than other cancer types. Recent studies have highlighted that deficiencies in the DNA damage response (DDR) can drive increased genomic instability and tumor immunogenicity, which leads to enhanced responses to ICB. Protein phosphatase 4 (PP4) is a critical regulator of the DDR; however, its potential role in antitumor immunity is currently unknown.ResultsOur results show that the PP4 inhibitor, fostriecin, combined with carboplatin leads to increased carboplatin sensitivity, DNA damage, and micronuclei formation. Using multiple OC cell lines, we show that PP4 inhibition orPPP4Cknockdown combined with carboplatin triggers inflammatory signaling via Nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 1 (STAT1) activation. This resulted in increased expression of the pro-inflammatory cytokines and chemokines:CCL5,CXCL10, andIL-6. In addition,IFNB1expression was increased suggesting activation of the type I interferon response. Conditioned media from OC cells treated with the combination of PP4 inhibitor and carboplatin significantly increased migration of both CD8 T cell and natural killer (NK) cells over carboplatin treatment alone. Knockdown of stimulator of interferon genes (STING) in OC cells significantly abrogated the increase in CD8 T-cell migration induced by PP4 inhibition. Co-culture of NK-92 cells and OC cells withPPP4CorPPP4R3Bknockdown resulted in strong induction of NK cell interferon-γ, increased degranulation, and increased NK cell-mediated cytotoxicity against OC cells. Stable knockdown of PP4C in a syngeneic, immunocompetent mouse model of OC resulted in significantly reduced tumor growthin vivo. Tumors with PP4C knockdown had increased infiltration of NK cells, NK T cells, and CD4+T cells. Addition of low dose carboplatin treatment led to increased CD8+T-cell infiltration in PP4C knockdown tumors as compared with the untreated PP4C knockdown tumors.ConclusionsOur work has identified a role for PP4 inhibition in promoting inflammatory signaling and enhanced immune cell effector function. These findings support the further investigation of PP4 inhibitors to enhance chemo-immunotherapy for OC treatment.
Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study
Authors: Curti Brendan D , Richards Jon , Hyngstrom John R , Daniels Gregory A , Faries Mark , Feun Lynn , Margolin Kim A , Hallmeyer Sigrun , Grose Mark , Zhang Yiwei , Li Anlong , Andtbacka Robert H I 
Published: December 2022

BackgroundIntratumoral administration of V937, a bioselected, genetically unmodified coxsackievirus A21, has previously demonstrated antitumor activity in patients with advanced melanoma as monotherapy and in combination with the programmed cell death 1 (PD-1) antibody pembrolizumab. We report results from an open-label, single-arm, phase 1b study (NCT02307149) evaluating V937 plus the cytotoxic T-lymphocyte antigen 4 inhibitor ipilimumab in patients with advanced melanoma.MethodsAdult patients (aged ≥18 years) with histologically confirmed metastatic or unresectable stage IIIB/C or IV melanoma received intratumoral V937 on days 1, 3, 5, 8, and 22 and every 3 weeks (Q3W) thereafter for up to 19 sets of injections plus intravenous ipilimumab 3 mg/kg Q3W administered for four doses starting on day 22. Imaging was performed at screening, on days 43 and 106 and every 6 weeks thereafter; response was assessed by immune-related response criteria per investigator assessment. Primary endpoints were safety in all treated patients and objective response rate (ORR) in all treated patients and in patients with disease that progressed on prior anti-PD-1 therapy.ResultsFifty patients were enrolled and treated. ORR was 30% (95% CI 18% to 45%) among all treated patients, 47% (95% CI 23% to 72%) among patients who had not received prior anti-PD-1 therapy, and 21% (95% CI 9% to 39%) among patients who had experienced disease progression on prior anti-PD-1 therapy. Tumor regression occurred in injected and non-injected lesions. Median immune-related progression-free survival was 6.2 months (95% CI 3.5 to 9.0 months), and median overall survival was 45.1 months (95% CI 28.3 months to not reached). The most common treatment-related adverse events (AEs) were pruritus (n=25, 50%), fatigue (n=22, 44%), and diarrhea (n=16, 32%). There were no V937-related dose-limiting toxicities and no treatment-related grade 5 AEs. Treatment-related grade 3 or 4 AEs, all of which were considered related to ipilimumab, occurred in 14% of patients (most commonly dehydration, diarrhea, and hepatotoxicity in 4% each).ConclusionsResponses associated with intratumoral V937 plus ipilimumab were robust, including in the subgroup of patients who had experienced disease progression on prior anti-PD-1 therapy. Toxicities were manageable and consistent with those of the individual monotherapies.
Motion artifact correction for cone beam CT stroke imaging: a prospective series
Authors: Cancelliere Nicole M , van Nijnatten Fred , Hummel Eric , Withagen Paul , van de Haar Peter , Nishi Hidehisa , Agid Ronit , Nicholson Patrick , Hallacoglu Bertan , van Vlimmeren Marijke , Pereira Vitor M 
Published: December 2022

BackgroundImaging assessment for acute ischemic stroke (AIS) patients in the angiosuite using cone beam CT (CBCT) has created increased interest since endovascular treatment became the first line therapy for proximal vessel occlusions. One of the main challenges of CBCT imaging in AIS patients is degraded image quality due to motion artifacts. This study aims to evaluate the prevalence of motion artifacts in CBCT stroke imaging and the effectiveness of a novel motion artifact correction algorithm for image quality improvement.MethodsPatients presenting with acute stroke symptoms and considered for endovascular treatment were included in the study. CBCT scans were performed using the angiosuite X-ray system. All CBCT scans were post-processed using a motion artifact correction algorithm. Motion artifacts were scored before and after processing using a 4-point scale.ResultsWe prospectively included 310 CBCT scans from acute stroke patients. 51% (n=159/310) of scans had motion artifacts, with 24% being moderate to severe. The post-processing algorithm improved motion artifacts in 91% of scans with motion (n=144/159), restoring clinical diagnostic capability in 34%. Overall, 76% of the scans were sufficient for clinical decision-making before correction, which improved to 93% (n=289/310) after post-processing with our algorithm.ConclusionsOur results demonstrate that CBCT motion artifacts are significantly reduced using a novel post-processing algorithm, which improved brain CBCT image quality and diagnostic assessment for stroke. This is an important step on the road towards a direct-to-angio approach for endovascular thrombectomy (EVT) treatment.
Chemotherapy-induced hand foot syndrome: comparative efficacy and safety of pharmacological prophylaxis – systematic review and Bayesian network meta-analysis
Authors: Ramasubbu Mathan Kumar , Maji Shampa , Padhan Milan , Maiti Rituparna , Hota Debasish , Majumdar Saroj Kumar Das , Srinivasan Anand 
Published: December 2022

BackgroundHand-foot syndrome (HFS) is one of the most common toxicities experienced by patients receiving systemic chemotherapy agents such as capecitabine and multikinase inhibitors such as sorafenib. Several randomised controlled trials (RCTs) have investigated the efficacy and safety of prophylactic agents such as pyridoxine, celecoxib, urea cream and cystine/theanine in managing HFS. This network meta-analysis (NMA) evaluated data from high-quality trials to provide strong evidence in forming recommendations to prevent systemic cancer therapy-induced HFS.ObjectiveTo examine the comparative efficacy and safety of interventions for preventing systemic chemotherapy-induced HFS in patients with cancer.MethodsWe searched PubMed, Embase and clinical trial registry for RCTs of interventions for preventing HFS. Bayesian NMA was performed to estimate the OR with 95% credible intervals (CrI) from both direct and indirect evidence. The outcome measures were the incidence of HFS (grade ≥1) and moderate to severe HFS (grade ≥2). Adverse drug reactions were discussed descriptively.ResultsA total of 15 RCTs with 2715 patients with 12 prophylactic strategies were included. The analysis showed only celecoxib could significantly prevent the incidence of moderate to severe HFS (grade ≥2) (OR 0.29, 95% CrI 0.13 to 0.68). But none of the preventive interventions could prevent the incidence of HFS (grade ≥1).ConclusionOnly celecoxib (200 mg two times per day) showed significant prevention of the incidence of moderate to severe HFS. Pyridoxine (400 mg once daily) and urea cream (10%) have to be evaluated further in larger randomised trials.
The JADE experiment at the PETRA $$e^+e^-$$ collider: history, achievements and revival
Authors: Bethke S. , Wagner A. 
Published: December 2022

AbstractThe JADE experiment was one of five large detector systems taking data at the electron–positron collider PETRA, from 1979 to 1986, at $$e^+e^-$$

e
+

e
-

annihilation centre-of-mass energies from 12 to 46.7 GeV. The forming of the JADE collaboration, the construction of the apparatus, the most prominent physics highlights, and the post-mortem resurrection and preservation of JADE’s data and software are reviewed.
Carpal Tunnel Volume after Basal Joint Arthroplasty in Postmenopausal Women
Authors: KUBOTA Yutaka , KAWASAKI Keikichi , KUBO Kazutoshi , NEMOTO Tetsuya , TOYOSHIMA Yoichi , INAGAKI Katsunori 
Published: December 2022

Background: Carpal tunnel syndrome is occasionally associated with basal joint arthritis and is more common in postmenopausal women than in the general population. Currently, more evidence is needed to describe changes in the carpal tunnel after basal joint arthroplasty (BJA) of the thumb and to determine whether it is better to combine the release of the flexor retinaculum. The purpose of this study was to clarify the changes in the carpal tunnel cross-sectional area and carpal tunnel shape after complete removal of the trapezium during BJA of the thumb, according to computed tomography (CT) findings. Methods: We retrospectively investigated the carpal tunnel cross-sectional area with CT findings obtained pre- and postoperatively in 20 postmenopausal women who underwent BJA of the thumb. Results: The average horizontal plane area of the carpal tunnel was 1.11 ± 0.19 cm2 preoperatively and increased to 1.23 ± 0.2 cm2 at 3 months postoperatively (p = 0.0411). The ratio of the longitudinal diameter to the horizontal diameter was significantly increased from 0.6 ± 0.13 preoperatively to 1.23 ± 0.2 postoperatively (p = 0.0439). Conclusions: The increase in the carpal tunnel cross-sectional area was confirmed after BJA of the thumb. This increased carpal tunnel cross-sectional area changed as the longitudinal diameter increased, without changes in the horizontal diameter. Level of Evidence: Level IV (Therapeutic)
The arrow of time of brain signals in cognition: Potential intriguing role of parts of the default mode network
Authors: Deco Gustavo , Sanz Perl Yonatan , de la Fuente Laura , Sitt Jacobo D. , Yeo B. T. Thomas , Tagliazucchi Enzo , Kringelbach Morten L. 
Published: December 2022

Abstract
A promising idea in human cognitive neuroscience is that the default mode network (DMN) is responsible for coordinating the recruitment and scheduling of networks for computing and solving task-specific cognitive problems. This is supported by evidence showing that the physical and functional distance of DMN regions is maximally removed from sensorimotor regions containing environment-driven neural activity directly linked to perception and action, which would allow the DMN to orchestrate complex cognition from the top of the hierarchy. However, discovering the functional hierarchy of brain dynamics requires finding the best way to measure interactions between brain regions. In contrast to previous methods measuring the hierarchical flow of information using, for example, transfer entropy, here we used a thermodynamics-inspired, deep learning based Temporal Evolution NETwork (TENET) framework to assess the asymmetry in the flow of events, ‘arrow of time’, in human brain signals. This provides an alternative way of quantifying hierarchy, given that the arrow of time measures the directionality of information flow that leads to a breaking of the balance of the underlying hierarchy. In turn, the arrow of time is a measure of nonreversibility and thus nonequilibrium in brain dynamics. When applied to large-scale Human Connectome Project (HCP) neuroimaging data from close to a thousand participants, the TENET framework suggests that the DMN plays a significant role in orchestrating the hierarchy, that is, levels of nonreversibility, which changes between the resting state and when performing seven different cognitive tasks. Furthermore, this quantification of the hierarchy of the resting state is significantly different in health compared to neuropsychiatric disorders. Overall, the present thermodynamics-based machine-learning framework provides vital new insights into the fundamental tenets of brain dynamics for orchestrating the interactions between cognition and brain in complex environments.
The Dynamical Tropopause Location as a Potential Predictor for North Atlantic Tropical Cyclone Activity
Authors: Enz Bernhard M. , Neubauer David , Sprenger Michael , Lohmann Ulrike 
Published: December 2022

Abstract
Tropical cyclones are among the most devastating natural phenomena that can cause severe damage when undergoing landfall. In the wake of the poorly forecast 2013 North Atlantic hurricane season, Rossby wave breaking on the 350-K isentropic surface has been linked to tropical cyclone activity measured by the accumulated cyclone energy (ACE). Here, ERA5 data and HURDAT2 tropical cyclone data are used to argue that the latitude of the 2 potential vorticity unit (PVU; 1 PVU = 10−6 K kg−1 m2 s−1) contour on the 360-K isentropic surface in the western North Atlantic is linked to changes in vertical wind shear and relative humidity during the month of September. A more equatorward position of the 2-PVU contour is shown to be linked to an increase in vertical wind shear and a reduction in relative humidity, as manifested in an increased ventilation index, in the tropical western North Atlantic during September. The more equatorward position is further linked to a reduction in the number of named storms, storm and hurricane days, hurricane lifetime, and number of tropical cyclones making landfall. Changes in genesis location are shown to be of importance for the changes in landfall frequency and hurricane lifetime. In summary, the 2-PVU contour latitude in the western North Atlantic can, therefore, potentially be used as a predictor in seasonal and subseasonal forecasting.

Significance Statement
Forecasts for the North Atlantic hurricane season are operationally produced. Their aim is to predict the number of tropical cyclones and their total energy throughout the season. This study proposes to include the tropopause latitude in these forecasts, as it is shown to be linked to vertical wind shear and midtropospheric relative humidity in the western tropical North Atlantic. The tropopause latitude is thereby linked to the number of tropical cyclones, their lifetime, and the total energy throughout the season. This link is particularly strong during September.
Extreme Convective Rainfall and Flooding from Winter Season Extratropical Cyclones in the Mid-Atlantic Region of the United States
Authors: Su Yibing , Smith James A. , Villarini Gabriele 
Published: December 2022

Abstract
Extreme rainfall from extratropical cyclones and the distinctive hydrology of the winter season both contribute to flood extremes in the Mid-Atlantic region. In this study, we examine extreme rainfall and flooding from a winter season extratropical cyclone that passed through the eastern United States on 24/25 February 2016. Extreme rainfall rates during the 24/25 February 2016 time period were produced by supercell thunderstorms; we identify supercells through local maxima in azimuthal shear fields computed from Doppler velocity measurements from WSR-88D radars. Rainfall rates approaching 250 mm h−1 from a long-lived supercell in New Jersey were measured by a Parsivel disdrometer. A distinctive element of the storm environment for the 24/25 February 2016 storm was elevated values of convective available potential energy (CAPE). We also examine the climatology of atmospheric rivers (ARs)—like the February 2016 storm—based on an identification and tracking algorithm that uses Twentieth Century Reanalysis fields for the 66-yr period from 1950 to 2015. Climatological analyses suggest that AR frequency is increasing over the Mid-Atlantic region. An increase in AR frequency, combined with increasing frequency of elevated CAPE during the winter season over the Mid-Atlantic region, could result in striking changes to the climatology of extreme floods.
Revisiting the concept of constant tissue conductivities for volume estimation in dialysis patients using bioimpedance spectroscopy
Authors: Schneditz Daniel , Mussnig Sebastian , Krenn Simon , Hecking Manfred 
Published: December 2022

Rationale: Current estimation of body fluid volumes in hemodialysis patients using bioimpedance analysis assumes constant specific electrical characteristics of biological tissues despite a large variation in plasma Na+ concentrations [Na+], ranging from 130 to 150 mmol/L. Here, we examined the potential effect of variable [Na+] on bioimpedance-derived volume overload. Method: Volumes were calculated from published whole-body extra- and intracellular resistance data and relationships using either “standard” or “revised” specific electrical characteristics modeled as functions of [Na+]. Result: With “standard” assumptions, volumes increased with increasing [Na+]. The increase in volume overload was about 0.5 dm3 and 3% of extracellular volume per 10 mmol/dm3 of [Na+] in a 75 kg patient. This increase was abolished when the same bioimpedance data were analyzed under “revised” conditions. Discussion: The overestimation in extracellular volume overload in the range of 0.5 dm3 per 10 mmol/dm3 [Na+] perfectly matches the positive relationship determined in a large cohort of hemodialysis patients. The bias may be considered moderate when interpreting data of individual patients, but may become important when comparing data of larger patient groups. The bias disappears when analysis of bioimpedance data accounts for differences in tissue electrical properties, using individual [Na+].
Cross-sectional area and echo intensity values of peripheral nerves: Ultrasonographic and cadaveric correlation
Authors: Rawat Mohini , Reddin Vanessa M , Boggs Ryan , Upreti Chirag 
Published: December 2022

Introduction: Ultrasonography allows high-resolution visualisation of the peripheral nerves for quantitative and qualitative analyses. We report cross-sectional area values (quantitative measure) and echo intensity values (qualitative measure) for 46 peripheral nerve sites in upper and lower extremities in cadaveric specimens. Objective: To determine cross-sectional area values and echo intensity values of peripheral nerves of upper and lower extremities at 46 nerve sites. Methods: Nerve measurements were obtained using electronic callipers and ultrasonography for linear dimension and cross-sectional area measurements, respectively, in six cadaveric specimens for 46 peripheral nerve sites. Ultrasound images were further analysed to estimate echo intensity percentage values for 46 nerves. Results: We present normal cross-sectional area values of various nerves of upper and lower extremities with their respective echo intensity values. Calculated cross-sectional area values from linear dimensions did not match the measured cross-sectional area values via trace method. Conclusion: Cross-sectional area values (quantitative measure) and echo intensity values (qualitative measure) for 46 peripheral nerve sites in upper and lower extremities in cadaveric specimens are presented. The estimation of cross-sectional area via linear measurement is not a good approximation of the cross-sectional area (cross-sectional area measured by trace method on ultrasound image).
Virtual group-based mindfulness program for autistic women: A feasibility study
Authors: Redquest Brianne , Tint Ami , St. John Laura , Hutton Sue , Palmer Pamela , Lunsky Yona 
Published: December 2022

Background: Autistic women experience life differently than autistic men. For example, autistic women tend to be diagnosed significantly later than autistic men, they experience a higher number of traumas, and are at increased risk for mental health conditions. Given gender-specific life experiences, autistic women may benefit from gender-specific group-based supports. Virtual mindfulness has been shown to be helpful in improving well-being among autistic adults; however, limited research has explored the impact of virtual mindfulness when it is delivered to a group of autistic women only. Objectives: The aim of this article is to describe a preliminary evaluation of a virtual mindfulness group piloted for autistic women. Five key areas of feasibility were assessed in the current study: demand, implementation, acceptability, practicality, and limited efficacy testing. Methods: Twenty-eight women participated in a 6-week virtual autism-informed mindfulness program and were asked to complete measures assessing psychological distress, self-compassion, and mindfulness at pre and post. Participants were also asked to complete a satisfaction survey after the program. Results: Results showed that the program was feasible in terms of demand, implementation, practicality, and acceptability. While quantitative results showed there were no changes in psychological distress, self-compassion, and mindfulness from pre- to post-program, qualitative results showed some benefits. Conclusion: Given the unique challenges that some autistic women experience, offering groups to autistic women may have some value and it would be important to continue exploring this topic area.