bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of diarrheal shellfish toxins
Authors: Xu Rui , Zhao Xiyan , Zhao Guangxi , Yang Yang 
Published: January 2023

Abstract
Seafood poisoning outbreaks are often caused by biotoxins generated by harmful algal blooms. Shellfish toxins, mainly derived from phytoplankton, cause diarrhea and poisoning in humans who consume contaminated seafood. Many studies suggest that diarrheal shellfish toxins cause functional changes in various cells. In order to protect shellfish products, it is becoming increasingly important to remove these contaminants from the ocean. Public attention plays a crucial role in reducing the risk of acute intoxication caused by contaminated seafood. Monitoring algal toxins is the best way to ensure that seafood is safe and clean. In order to attain these objectives, a variety of technologies were developed and constructed for the purpose of detecting and decontaminating algal toxins in aquatic environments. A review of the current literature regarding the detection and detoxification of diarrheal shellfish toxins is presented in this article.
Mystifications. The role of pseudonyms in postmodern Hungarian literature
Authors: Németh Zoltán 
Published: January 2023

AbstractThis study focuses on literary mystification, which has become extremely common in Central European postmodern literature in recent decades. Mystification is essentially a game related to the authorial name, to pseudonyms, masks and various alter egos. The paper attempts to separate three procedures of postmodern text creation by considering the aspect of mystification: early postmodern text creation, based on the principle of imitation; areferential postmodernism, based on simulation, and the anthropological postmodern, which is present through a transitive strategy. The study analyses the pseudonymised works, among others, of István Baka, Árpád Tőzsér, Péter Esterházy, Lajos Parti Nagy, András Ferenc Kovács and Zoltán Csehy.
Women writers and the possibility of a women's literary tradition in Transylvanian Hungarian literature
Authors: Balázs Imre József 
Published: January 2023

AbstractWithin the regional literary canon of Transylvanian Hungarian literature, female authors had a marginal position during the last century, as a quantitative methodology can show. The objective of the paper is to point out the structural dimensions of this marginalization, through exploring patterns in the reception of women authors, and characteristics of the literary field of Transylvanian Hungarian literature. The question is whether thematic or genre issues, the prestige of certain literary and cultural forms (like memoirs, children's literature, theatre etc.) affected during the past century the canonical position of female authors. The analysis outlines a possible structure of a women's literary tradition.
Baroque tradition in early Romanticism •
Authors: Bene Sándor 
Published: January 2023

AbstractThe elaboration of a canon of literary tradition was a key issue within the renewal of Hungarian literature at the turn of the 18th and 19th centuries. The leading figures of the movement, Ferenc Kazinczy (1759–1831) and Ferenc Kölcsey (1790–1838), both saw Miklós Zrínyi's (1620–1664) poetry collection Adriai tengernek Syrenaia (Syrena of the Adriatic Sea), published in 1651, as a model that offered aesthetic value, national ideology, and an example for reforming the literary language. The present study examines the extent to which these aspirations may be linked to the poetic modernity of Zrínyi's time, the first half of the 17th century, and concludes that the Syrena volume was not simply a model for the successors, but it can be philologically proven that Kazinczy and his circle (mainly by following Francis Bacon) continued the agenda initiated by Zrínyi. In this sense, the waves of modernity do not follow one another, but are layered on top of one another in the history of Hungarian literature.
La automatización de la silogística aristotélica. Fundamentos lógico-fenomenológicos del autómata Silogismos
Authors: Vargas Guillén Germán 
Published: January 2023

El objetivo de este artículo es mostrar los fundamentos de la investigación en la cual se ha desarrollado Silogismos, un autómata que realiza la inferencia, identifica figura y modo de los silogismos, reconoce y diferencia entimemas y sofismas; éste fue desarrollado en Prolog -una plataforma de Inteligencia Artificial (IA)- como parte de un proyecto de investigación tendiente a representar computacionalmente la mente tal y como la concibió Aristóteles, para el caso de la lógica en el Órganon, para el caso de la persuasión en la Retórica, etcétera. En el §1 se presenta el contexto de esta investigación; en el §2. de manera particular, se caracteriza el aporte de la silogística a la IA y a la filosofía de la mente, en el §3 se establecen las limitaciones de la lógica aristotélica para su automatización; en el §4 se estudia la perspectiva de investigación abierta con los proyectos de automatización.
concepto de técnica en Homero
Authors: Carvajal Ahumada Germán 
Published: January 2023

Este ensayo apunta a demostrar que el concepto de técnica en los poemas homéricos, Ilíada y Odisea, dista mucho de referirse a un atributo exclusivamente intelectual. La tesis aquí desarrollada es que el concepto en Homero apunta a pensar una disposición de orden corporal o intelectual que permite el desenvolvimiento del sujeto en un entorno circunstancial. El desarrollo del escrito es un examen de las formas de aparición del concepto en los poemas homéricos, para aislar su significado fundamental: primero en la Ilíada, luego en la Odisea y finalmente, la relación que este concepto guarda con la noción de saber.
La metodología de Newton y la demostración de la realidad de la fuerza
Authors: Molina Betancur Sebastián 
Published: January 2023

Algunos especialistas de Newton han sostenido que la metodología con la que éste demuestra la existencia de la fuerza se fundamenta en el tratamiento matemático de los fenómenos del movimiento, lo que se ha convertido en la lectura clásica del asunto. No obstante, esta interpretación presenta amplias limitaciones si se examina a la luz de la lectura que intérpretes como Guicciardini y Guerlac proponen. Este artículo muestra las limitaciones de la lectura clásica a la luz de esta lectura más reciente, explorando los aspectos metodológicos de la demostración de la fuerza.
La razón transversal. La posición de Wolfgang Welsch en el enfrentamiento entre modernidad y postmodernidad
Authors: Pöppel Hubert 
Published: January 2023

En una primera parte, el artículo reconstruye el debate entre filósofos alemanes y franceses sobre los conceptos de modernidad o postmodernidad en los años ochenta, con especial hincapié en las contribuciones de Jürgen Habermas y Jean-François Lyotard. La segunda parte se dedica a la presentación de las tesis de Wolfgang Welsch quien, desde 1987, replantea el concepto de razón (Vernunft), para superar esa confrontación y para proponer, con la razón transversal, una nueva teoría de la razón.
Congoja por una educación contable fútil
Authors: Rojas Rojas Willian 
Published: January 2023

este ensayo se ubica en el dominio de la reflexión sobre la educación contable, en especial aquella que debe permitir que el estudiante comprenda la complejidad de su tiempo, instalado como sujeto político y estético. La tendencia generalizada a ofertar una educación tecnocrática, desprovista de fundamentos científicos, facilista y lineal, sumada a las motivaciones que inducen al estudiante a escoger la profesión contable como campo de formación (acenso económico, facilidades para trabajar, jornada nocturna) lejanas de una necesidad real por saber, señalan un panorama que no se corresponde con los ideales de la educación universitaria. La incorporación del estudio de las ciencias humanas y sociales en los currículos, ofrece un camino en el que es posible pensar una educación contable que le entregue al estudiante espacios para pensar críticamente su formación y su ejercicio profesional en las organizaciones, además de su importante papel como sujeto social.
Los activos y pasivos financieros en la nueva economía. Adaptación contable en el caso español
Authors: Monclús Guitart Richard , Vidal Blasco María Arantzazu 
Published: January 2023

los cambios económicos y financieros en el entorno, así como la globalización de la economía, hicieron necesaria una reforma contable para adaptar la información financiera a lasituación internacional. La normativa contable española se ha reformado para adecuarse a las Normas Internacionales de Contabilidad (NIC/NIIF) elaboradas por el Internacional Accounting Standard Board (IASB). Fruto de este proceso de reforma surge el nuevo Plan General de Contabilidad español (PGC). Analizamos una de las novedades más importantes recogidas en el nuevo PGC español, a saber, el tratamiento de los instrumentos financieros, en particular, de los activos y pasivos financieros.
Integrating and Securing Video, Audio and Text Using Quaternion Fourier Transform
Authors: ElSharkawy Magdy Ibrahim 
Published: January 2023

The rapid growth of communication technology encouraged a rapidly rising demand for Internet connectivity. Accordingly, this led to an upsurge in research in the discipline of information security. cryptography plays a significant role in securing and verification of information exchanged via public communication channels. The current paper introduces a novel approach for combining both video, audio and text signals into a single architecture and securing it prior to the process of transmission. The idea behind this approach depends on embedding the color components of each pixel of the video signal in a quaternion number. The fourth component of the quaternion number is occupied with either an audio sample or a textual data. The array of quaternion numbers corresponding to a video frame is converted to the frequency domain, using quaternion Fourier transform, and then multiplied by the quaternion Fourier transform of a digital image. Herby, the selected digital image is used as a complicated secret. The yielded signal is transmitted and when received, both of video, audio and text signals are extracted using simple quaternion mathematics applied to the received signal and a copy of the digital image. A second level of complexity can be added to this approach by applying one of the well-known cryptographic techniques (symmetric or asymmetric) to the samples of the transmitted signal. The suggested approach is implemented using Matlab simulation software and the extracted signals are compared with the original ones using some performance metrics. The obtained results show that the proposed approach is robust and more secure against cryptanalysis attacks without affecting the used bandwidth of the communication channel.
Drug use evaluation and rational prescription audit of restricted antibiotics in tertiary care corporate hospital: An interventional study
Authors: Teli Avinash , Azad Danish , Bashir Rifat 
Published: January 2023

: Antimicrobial agent are the biggest contribution to 20th century, which are used to prevent and cure of the infections. Over use of antimicrobials has facilitated the development of resistance. Drug utilization research help in identification of clinical use of drugs in populations and its impact on healthcare system.: The aim of the study is to identify the overuse/misuse of the antibiotic usage in our intensive care unit. which helps in rationalising the antibiotic prescription and to avoid emergence of drug resistance and to improve better patient’s outcome. An observational audit has been conducted in inpatient admitted in our set up and has been prescribed with restricted antimicrobials. The audit has been done for 3 months. The Audit report for 218 patients have been prescribed with Restricted antimicrobials either one or more than one. The audit report shows that Meropenem and Colistin was prescribed more often 81 and 73 respectively. Geriatric Patients have been prrscribed more with Antimicrobials than other age groups. 193 patients were on single Restricted antimicrobial therapy, 24 patients were on dual restricted antimicrobial therapy and one patient was on more than 2 Restricted antimicrobial therapy. Out of 218 Prescription having Restricted Antibiotics, 39 prescription were found irrational. A wide spectrum of clinical diagnoses and a variety of drugs were utilized from various antibiotic classes. Results showed that Carbapenems(Meropenem) antibiotics were extensively used in ICU. Among Colistin and Vancomycin was most commonly prescribed. Policy for rational usage of restricted antimicrobial agents in ICU should be implemented and education needs to be provided.
Clinical Profile of Children with Pyelonephritis and Cystitis in Dr. Soetomo General Academic Hospital, Surabaya
Authors: Hilwana Lutifta , Soemyarso Ninik Asmaningsih , Atika Atika 
Published: January 2023

Highlights:1. In patients younger than one year old, cystitis was more frequent in boys. Meanwhile, in patients aged 1-5, girls were more frequent in pyelonephritis and cystitis.2. In pyelonephritis, all patients had fever, followed by diarrhea and lethargy.3. Urinary symptoms, such as dysuria and hematuria, were more frequent in cystitis than in pyelonephritis.
AbstractIntroduction: Urinary tract infection (UTI) is a common infection in children. Prompt diagnosis and treatment of this infection are important to prevent further damage to the kidney. This study aimed to examine the clinical profile of children with pyelonephritis and cystitis in Dr. Soetomo General Academic Hospital, Surabaya.Methods: This was a descriptive study conducted in Dr. Soetomo General Academic Hospital, Surabaya, from June 2013 until December 2015, using secondary data and presented by percentage. Samples included in this study were children aged two months to five years old with UTI as a primary or secondary diagnosis of diarrhea and had urine culture results ≥ 105 CFU/ml.Results: There were 30 patients with pyelonephritis and 27 patients with cystitis. The prevalence of pyelonephritis was 0.285% and of cystitis was 0.247%. In pyelonephritis patients younger than one-year-old, boys and girls were equal. However, boys (60%) were more frequent in cystitis patients. In both pyelonephritis and cystitis patients aged 1-5, girls were more frequent (56.3%; 64.7%). In pyelonephritis patients, all patients were found with fever, followed by diarrhea (60%) and lethargy (56.7%) as the two most common symptoms. The two most common symptoms in cystitis patients were lethargy (44.4%) and irritability (33.3%). Urinary symptoms, such as dysuria and hematuria, were more frequent in cystitis (11.1%; 7.4%) patients than in pyelonephritis patients.Conclusion: Boys were more frequent to suffer urinary tract infections. Systemic symptoms were frequently found in pyelonephritis patients, while urinary symptoms were more frequent in cystitis patients.
Intravenous functional gene transfer throughout the brain of non-human primates using AAV
Authors: Chuapoco Miguel , Flytzanis Nicholas , Goeden Nick , Octeau J , Roxas Kristina , Chan Ken , Scherrer Jon , Winchester Janet , Blackburn Roy , Campos Lillian , Man Kwun-Nok , Sun Junqing , Chen Xinhong , Lefevre Arthur , Singh Vikram , Arokiaraj Cynthia , Miles Timothy , Vendemiatti Julia , Jang Min , Mich John , Bishaw Yeme , Gore Bryan , Omstead Victora , Taskin Naz , Weed Natalie , Ting Jonathan , Miller Cory , Deverman Benjamin , Pickel James , Tian Lin , Fox Andrew , Gradinaru Viviana 
Published: January 2023

Abstract
Adeno-associated viruses (AAVs) promise robust gene delivery to the brain through non-invasive, intravenous delivery. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood-brain barrier in non-human primates (NHPs). Here we describe AAV.CAP-Mac, an engineered variant identified by screening in adult marmosets and newborn macaques with improved efficiency in the brain of multiple NHP species: marmoset, rhesus macaque, and green monkey. CAP-Mac is neuron-biased in infant Old World primates, exhibits broad tropism in adult rhesus macaques, and is vasculature-biased in adult marmosets. We demonstrate applications of a single, intravenous dose of CAP-Mac to deliver (1) functional GCaMP for ex vivo calcium imaging across multiple brain areas, and (2) a cocktail of fluorescent reporters for Brainbow-like labeling throughout the macaque brain, circumventing the need for germline manipulations in Old World primates. Given its capabilities for systemic gene transfer in NHPs, CAP-Mac promises to help unlock non-invasive access to the brain.
A Novel Method for Precise Ulna-Shortening Osteotomy
Authors: Yang Xi , Zhang Jianping , Mo Wenqian , Shi Yan , Fang Xiang , Liu Wuhua , Xu Yongqing , He Xiaoqing 
Published: January 2023

Abstract
Background: Ulnar impaction syndrome caused by positive ulnar variance often requires ulnar shortening osteotomy (USO) to unload the ulnocarpal joint. The therapeutic effect of USO in treatment of ulnar impaction syndrome is limited due to complications such as hardware irritation, non-union rotation and angulation. Despite various devices have been introduced to overcome these limitations, more accurate and simple devices are still needed. The purpose of this study was to introduce a novel method of the ortho-bridge fixation system combined with 3D-printed guide plate to achieve precise ulnar shortening osteotomy with less complications simply.
Methods: This was a retrospective study comprising nine patients with ulnar impaction syndrome who underwent ulnar shortening osteotomy by this method. The CT scan data of patients were retrieved for printing the osteotomy guide plate. The ortho-bridge system served as ulnar shortening and internal fixation. The outcome measurements included the time to union, complications, range of motion, grip strength and wrist pain.
Results: The ulna was shortened successfully in all of the nine cases without rotation and angulation. Non-union was not observed in any of the cases during follow-up between 12 months after surgery. The range of motion, grip strength and wrist pain also improved following surgery (p<0.05).
Conclusion: The ortho-bridge internal fixation system combined with 3D-printed osteotomy guide effectively simplified the procedure, and restored ulnar variance without rotation, angulation and non-union. It is a reliable method for treating ulnocarpal impaction syndrome through ulnar shortening osteotomy.
Cooling Oceans Did Trigger Ordovician Biodiversification
Authors: Ontiveros Daniel Eliahou , Beaugrand Grégory , Lefebvre Bertrand , Marcilly Chloé Markussen , Servais Thomas , Pohl Alexandre 
Published: January 2023

Abstract
Global cooling during the Ordovician (485 Ma to 443 Ma) has long been considered as a possible driver of the Great Ordovician Biodiversification Event (GOBE), the largest radiation of Phanerozoic marine animal Life. Yet, this hypothesis exclusively relies on temporal correlations. Mechanistic understanding of the underlying pathways is lacking and other possible causes are debated. Here we couple an ocean-atmosphere general circulation model with a macroecological model to reconstruct global biodiversity patterns from 490 Ma to 430 Ma. Our results demonstrate that the GOBE permitted the development of a Modern-like Latitudinal Biodiversity Gradient (LBG). Inverted LBGs, with biodiversity increasing from the equator to the poles, characterize the late Cambrian and Early Ordovician when climate was much warmer than today. A Modern LBG develops in the Mid-Late Ordovician in response to the drop in ocean temperatures. Globally, simulated biodiversity increases due to long-term cooling during the Ordovician. This increase is a consequence of the ecophysiological limitations to marine Life and is robust to uncertainties in both proxy-derived temperature reconstructions and organism physiology. First-order model-data agreement suggests that the most conspicuous rise in biodiversity over Earth’s history –GOBE– was primarily driven by global cooling.
Structural basis for negative regulation of the Escherichia coli maltose system
Authors: Wu Yuang , Sun Yue , Richet Evelyne , Han Zhifu , Chai Jijie 
Published: January 2023

Abstract
Proteins from the signal transduction ATPases with numerous domains (STAND) family are known to play an important role in innate immunity. However, it remains less well understood how they function in transcriptional regulation. MalT is a bacterial STAND that controls the Escherichia coli maltose system. Inactive MalT is sequestered by different inhibitory proteins such as MalY. Here, we show that MalY interacts with one oligomerization interface of MalT to form a 2:2 complex. MalY represses MalT activity by blocking its oligomerization and strengthening ADP-mediated MalT autoinhibition. A loop region N-terminal to the nucleotide-binding domain (NBD) of MalT has a dual role in mediating MalT autoinhibition and activation. Structural comparison shows that ligand-binding induced oligomerization is required for stabilizing the C-terminal domains and conferring DNA-binding activity. Together, our study reveals the mechanism whereby a prokaryotic STAND is inhibited by a repressor protein, and offers insights into signaling by STAND transcription activators.
Comparison of the correlation between serum autoantibodies against aldehyde dehydrogenase 2 and thyrotropin receptor in patients with Graves’ ophthalmopathy
Authors: Lin Chia-Ching , Chiu Li-Wen , Lee Po Yen , Chen Kuo-Jen , Cheng Kai 
Published: January 2023

Abstract
Objectives: Graves’ ophthalmopathy (GO) is an autoimmune disorder characterized by orbital inflammation related to Graves’ disease. Identifying the titers of potential autoimmune target such as thyrotropin receptor autoantibody (TRAb) and anti-aldehyde dehydrogenase 2 (ALDH2) antibody could be valuable and convenient in evaluating clinical activity and severity of GO to provide necessary treatment. This study aims to investigate the correlations among serum titers of anti-ALDH2 antibody and TRAb, thyroid function and clinical activity of GO.
Methods: We retrospectively reviewed the medical records of fifty GO patients to identify the correlation coefficients between anti-ALDH2 antibody and the Clinical Activity Score (CAS); anti-ALDH2 antibody and TRAb; and TRAb and thyroid-related biochemical parameters using Pearson’s correlation.
Results: After the analysis, there was a positive significant association between anti-ALDH2 antibody and CAS (r=0.301, P=0.033); however, no relationship was found between anti-ALDH2 antibody and TRAb (r=0.109, P=0.452). Additionally, TRAb was correlated with T3 (r=0.333, P=0.018), free-T4 (r=0.336, P=0.017) and TSH (r=-0.315, P=0.026), yet not associated with CAS (r=-0.009, P=0.948) as well.
Conclusions: Anti-ALDH2 antibody could be a suitable assessment tool to evaluate the clinical activity of GO for providing patients with necessary treatment. The significant correlation between anti-ALDH2 antibody and CAS indicated that it might be more specific to the orbital tissues in GO patients compared to TRAb, which is instead more specific to the thyroid function.