bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase 1/2a safety, pharmacokinetics, and efficacy study of the novel nucleoside analog FF‐10502‐01 for the treatment of advanced solid tumors
Authors: Janku Filip , Javle Milind M. , Sen Shiraj , Pant Shubham , Bramwell Lindsay G. , Subbiah Vivek , Way Tracey , Wages David S. , Wheeler Catherine A. , Suzuki Takeaki , Saeki Kazunori , Subach Ruth Ann , Madden Timothy , Maier Gary , Johansen Mary J. , Cheung Kin , Falchook Gerald S. 
Published: March 2023

AbstractBackgroundThe nucleoside FF‐10502‐01, structurally similar to but with different biologic effects than gemcitabine, shows promising activity both alone and combined with cisplatin in preclinical gemcitabine‐resistant tumor models. We conducted an open‐label, single‐arm, 3 + 3 first‐in‐human trial to explore the safety, tolerability, and antitumor activity of FF‐10502‐01 in patients with solid tumors.MethodsPatients with inoperable metastatic tumors refractory to standard therapies were enrolled. Escalating intravenous FF‐10502‐01 doses (8–135 mg/m2) were administered weekly for 3 weeks in 28‐day cycles until progressive disease or unacceptable toxicity was observed. Three expansion cohorts were subsequently evaluated.ResultsA phase 2 dose of 90 mg/m2 was determined after evaluating 40 patients. Dose‐limiting toxicities included hypotension and nausea. Phase 2a enrolled patients with cholangiocarcinoma (36), gallbladder cancer (10), and pancreatic/other tumors (20). Common adverse events were grade 1–2 rash, pruritus, fever, and fatigue. Grade 3 or 4 hematologic toxicities were observed at low incidences, including thrombocytopenia (5.1%) and neutropenia (2%). Confirmed partial responses (PRs) occurred in five patients with gemcitabine‐refractory tumors, including three with cholangiocarcinoma and one each with gallbladder and urothelial cancer. Median progression‐free and overall survival rates in patients with cholangiocarcinoma were 24.7 and 39.1 weeks, respectively. Prolonged progression‐free survival in patients with cholangiocarcinoma was associated with BAP1 and PBRM1 mutations.ConclusionFF‐10502‐01 was well tolerated with manageable side effects and limited hematologic toxicity. Durable PRs and disease stabilizations were observed in heavily pretreated biliary tract patients who had received prior gemcitabine. FF‐10502‐01 is distinct from gemcitabine and may represent an effective therapy.
Spatial‐temporal aware service composition for production factors under industrial internet
Authors: Liu Jianxun , Xie Runbin , Kang Guosheng , Wen Yiping 
Published: March 2023

SummaryIndustrial Internet is a promising technology combining industrial systems with Internet techniques to significantly improve production efficiency and reduce cost by cooperating with intelligent devices. Under industrial internet environment, a production process usually consists of multiple subtasks, and one or more types of product factors are needed to finish a subtask. Thus, the service composition under industrial application is more complex and challenging compared with traditional service composition under the Internet environment. In this article, we model the problem of service composition for production factors under industrial internet as a multiobjective optimization problem. To derive the optimal Pareto service composition plans, we propose a hybrid optimization algorithm, named TLBO‐TS, by combining the advantages of teaching‐learning‐based optimization algorithm and tabu search algorithm. Extensive experiments are conducted to compare with other population‐based optimization methods under a real‐world ship production process to verify the superiority of our approach.
Unraveling the Nature and Strength of Non‐Covalent Interactions on the Surface of Fullerenes
Authors: Yamada Michio 
Published: March 2023

AbstractThe nature and strength of the noncovalent intermolecular interactions on the surface of fullerenes must be understood for the application of these molecules in pharmaceuticals and materials chemistry. Consequently, experimental and theoretical evaluations of such weak interactions have been conducted in parallel. Nevertheless, the nature of these interactions remains a topic of ongoing debate. In this context, this concept article summarizes recent advances in experimental and theoretical efforts aimed at characterizing the nature and strength of non‐covalent interactions on fullerene surfaces. Specifically, this article summarizes recent studies conducted on host‐guest chemistry based on various macrocycles and on catalyst chemistry based on conjugated molecular catalysts composed of fullerenes and amines. In addition, conformational isomerism analyses performed using fullerene‐based molecular torsion balances and state‐of‐the‐art computational chemistry are reviewed. These studies have enabled a comprehensive evaluation of the contributions of electrostatic, dispersion, and polar interactions on the surface of fullerenes.
Microglial morphology in the somatosensory cortex across lifespan. A quantitative study
Authors: Godeanu Sanziana , Clarke Devin , Stopper Laura , Deftu Alexandru‐Florian , Popa‐Wagner Aurel , Bălșeanu Adrian Tudor , Scheller Anja , Catalin Bogdan 
Published: March 2023

AbstractBackgroundMicroglia are long‐lived cells that constantly monitor their microenvironment. To accomplish this task, they constantly change their morphology both in the short and long term under physiological conditions. This makes the process of quantifying physiological microglial morphology difficult.ResultsBy using a semi‐manual and a semi‐automatic method to assess fine changes in cortical microglia morphology, we were able to quantify microglia changes in number, surveillance and branch tree starting from the fifth postnatal day to 2 years of life. We were able to identify a fluctuating behavior of most analyzed parameters characterized by a rapid cellular maturation, followed by a long period of relative stable morphology during the adult life with a final convergence to an aged phenotype. Detailed cellular arborization analysis revealed age‐induced differences in microglia morphology, with mean branch length and the number of terminal processes changing constantly over time.ConclusionsOur study provides insight into microglia morphology changes across lifespan under physiological conditions. We were able to highlight, that due to the dynamic nature of microglia several morphological parameters are needed to establish the physiological state of these cells.
Urban tolerance is phylogenetically constrained and mediated by pre‐adaptations in African bats
Authors: Marsden Genevieve E. , Vosloo Dalene , Schoeman M. Corrie 
Published: March 2023

AbstractWith increasing urbanization, particularly in developing countries, it is important to understand how local biota will respond to such landscape changes. Bats comprise one of the most diverse groups of mammals in urban areas, and many species are threatened by habitat destruction and land use change. Yet, in Africa, the response of bats to urban areas is relatively understudied. Therefore, we collated data on urban presence, phylogenetic relationship, and ecological traits of 54 insectivorous bats in Africa from available literature to test if their response to urbanization was phylogenetically and/or ecologically driven. Ancestral state reconstruction of urban tolerance, defined by functional group and presence observed in urban areas, suggests that ancestral African bat species could adapt to urban landscapes, and significant phylogenetic signal for urban tolerance indicates that this ability is evolutionarily conserved and mediated by pre‐adaptations. Specifically, traits of high wing loading and aspect ratio, and flexible roosting strategies, enable occupancy of urban areas. Therefore, our results identify the traits that predict which bat species will likely occur in urban areas, and which vulnerable bat clades conservation efforts should focus on to reduce loss of both functional and phylogenetic diversity in Africa. We, additionally, highlight several gaps in research that should be investigated in future studies to provide better monitoring of the impact urbanization will have on African bats.
Vegetation management shapes arthropod and bird communities in an African savanna
Authors: Parker Dan M. , Stears Keenan , Olckers Terence , Schmitt Melissa H. 
Published: March 2023

AbstractHabitat heterogeneity is a key driver of the diversity and distribution of species. African savannas are experiencing changes in their vegetation structure causing shifts towards increased woody plant cover, which results in vegetation structure homogenization. Given the impact that increasing woody plant cover has on patterns of animal use, resource managers across Africa are implementing habitat management practices that are intended to reduce woody plant cover. To understand the ecological implications of various habitat management practices on arthropod and bird communities, we leveraged large‐scale tree clearing and subsequent mowing in an African savanna to understand how changes in both the herbaceous layer and woody plant cover (i.e., structural heterogeneity) may shape arthropod and bird communities at the local scale. We focused on four replicated treatments: (1) annual summer mow, (2) annual winter mow, (3) >5 years since last mow (rest), and (4) an adjacent unmanipulated savanna to act as a control. We found that the mowing treatments significantly influenced vegetation structure both with respect to tree density and herbaceous layer. Both arthropod and bird community composition varied across treatments. Grass biomass was the best predictor of arthropod richness and abundance, with arthropods selecting for areas with high biomass. Insectivorous bird richness and abundance was driven by tree density (i.e., perching locations) and not arthropod abundance. Our results suggest that vegetation management practices contribute to habitat heterogeneity at the landscape scale and increase bird species richness through species turnover. However, we caution that if a single vegetation management practice dominates the landscape, it is plausible that it could lead to the simplification of the avian community.
The value of serum albumin concentration in predicting functional outcome of status epilepticus: An observational study
Authors: Liao Qiao , Li Si‐Zhuo , Zeng Qian‐Qian , Zhou Jin‐Xia , Huang Kun , Bi Fang‐Fang 
Published: March 2023

AbstractObjectiveStatus epilepticus (SE) is a common neurological emergency with unsatisfying prognoses, and accurate prediction of functional outcome is beneficial in clinical decision‐making. The relationship between serum albumin concentration and outcome of SE patients has yet to be unveiled.MethodsClinical profiles of SE patients admitted to Xiangya Hospital, Central South University, from April 2017 to November 2020, were analyzed retrospectively. Outcomes of SE patients at discharge were divided into two groups based on the modified Rankin Scale (mRS): favorable outcome (mRS: 0–3) and unfavorable outcome (mRS: 4–6).ResultsFifty‐one patients were enrolled. Unfavorable functional outcome at discharge was reported in 60.8% (31/51). Serum albumin concentration at admission and the Encephalitis‐NCSE‐Diazepam resistance‐Image abnormalities‐Tracheal intubation (END‐IT) score remained independent predictors for functional outcome of SE patients. A lower albumin concentration at admission and higher END‐IT score indicated a higher chance of unfavorable outcome for SE patients. The cut‐off value of serum albumin to predict unfavorable outcome was 35.2 g/L, with a sensitivity of 67.7% and specificity of 85.0%, and an area under the receiver operating characteristic curve (ROC) of .738 (95% CI: .600–.876, p = .004). The preferable END‐IT score with optimal sensitivity (74.2%) and specificity (60%) was 2 and the area under the ROC was .742, with 95% CI of .608–.876 (p = .004).SignificanceSerum albumin concentration at admission and the END‐IT score are two independent predictive factors for short‐term outcome of SE patients, moreover, the serum albumin concentration is not inferior to the END‐IT score in indicating functional outcome at discharge.
Provenance of the conglomerate and siliciclastic rocks from the Gadag Greenstone Belt, Western Dharwar Craton, India: Implications for understanding Neoarchean basin margin sedimentation
Authors: Pratihari Asim Ranjan , Hegde Venkatraman S. , McKenzie N. Ryan , Frimmel Hartwig E. , Shukla Anil D. , Hulaji Shivani 
Published: March 2023

Petrographic, whole‐rock geochemical and geochronological analysis of polymictic conglomerate, associated siltstone and greywacke in the Neoarchean Gadag Greenstone Belt in the Western Dharwar Craton, India, provides new insights into sedimentary provenance and tectonic setting. The polymictic conglomerate contains granitic, gneissic, felsic and mafic volcanic, quartzite and banded ferruginous chert clasts within a quartzo‐feldspathic matrix. Framework grains in the siltstone and greywacke are quartz, feldspar with rock fragments, embedded in a chlorite‐dominant matrix. The chemical index of alteration values (~70) and A‐CN‐K plot for the rocks suggest a low‐to‐moderate degree of weathering. Rare earth element (REE) patterns show moderate fractionation (LaN/YbN ~ 12.31) with a weak negative europium anomaly (0.82). Enrichment in transition elements (Ni, Cr, Co, Sc) and depletion in high‐field‐strength elements, as well as relatively low La/Co (0.62), moderate to high Th/Yb (3.06), La/Th (5.16), La/Yb (17.5), and La/Sc (~2.37) ratios, suggest a mixed felsic‐mafic provenance. U–Pb dating of detrital zircon from the conglomerate and greywacke revealed major age peaks at ca. (3.2, 2.9, 2.8, 2.6, 2.5 Ga) and a maximum age of deposition of 2,508 ± 26 Ma, 2,493 ± 20 Ma, respectively. The above data suggest low to moderately weathered proximal sources for both conglomerate and greywacke, indicating that these two rock types were not deposited simultaneously, but rather separately. The association of these conglomerates and greywacke with continental arc‐related volcanics indicates the closing of an arc at the time of sedimentation. Complex provenance consisting of recycled and magmatic arc during basin closure confirm the notion of modern style plate tectonics operating during Neoarchaean.
Breast cancer screening programmes and self‐reported mammography use in European countries
Authors: Cardoso Rafael , Hoffmeister Michael , Brenner Hermann 
Published: March 2023

AbstractMammography screening has been shown to be able to reduce breast cancer mortality, leading most European countries to implement mammography‐based screening programmes. In our study, we analysed key characteristics of breast cancer screening programmes and mammography use in European countries. Information on screening programmes were obtained from the 2017 European Union (EU) screening report, websites from governments and cancer registries, and through literature search in PubMed (studies published up to 20 June 2022). Data on self‐reported mammography use in the past 2 years were obtained from Eurostat and had been derived from the European health interview survey (cross‐sectional survey), conducted in the 27 EU countries, Iceland, Norway, Serbia, Turkey and the UK in 2013 to 2015 and 2018 to 2020. Data were analysed for each country according to their human development index (HDI). By 2022, all included countries besides Bulgaria and Greece had introduced an organised mammography‐based screening programme; Romania and Turkey had only pilot programmes. Screening programmes differ substantially across countries, particularly in timing of implementation (e.g., in Sweden, the Netherlands before 1990; Belgium, France between 2000 and 2004; Denmark, Germany between 2005 and 2009; Austria, Slovakia after 2010). Self‐reported mammography use also differed considerably across countries, and went along with HDI—from <36% in all countries with HDI <0.85 to >70% in most countries with HDI >0.90. The data call for efforts to improve mammography screening use across Europe, particularly in countries with lower development levels where breast cancer mortality rates are also among the highest in the region.
Relativistic Effects on Rate and Product Formation in the Gas‐Phase Methane Chemistry of Late Atomic Transition Metal Cations
Authors: Blagojevic Voislav , Böhme Diethard K. 
Published: March 2023

AbstractWe provide an assessment of relativistic effects on both rate and product formation in gas‐phase chemical reactions of methane with late atomic transition metal cations (Groups 8–12) at room temperature. In the spirit long advocated by Helmut Schwarz, we use the interplay between theory and experiment to illuminate any perceived trends and transitions in product formation and chemical kinetics with these atomic cations going down the periodic table.
Predicting base station return on investment in the telecommunications industry: Machine‐learning approaches
Authors: Şahin Cihan 
Published: March 2023

AbstractInvestment in the right location ensures sustainable competition. In the telecommunication sector, the number of base stations (BSs) is one of the most significant investment parameters. When a potential BS is subject to be selected, practitioners will first consider investing in a BS where the return on investment (ROI) is highest. Therefore, the quantifiable objectives are distinctly defined, as it makes sense to choose maximizing features that raise per unit investment. This study provides a solution to evaluate the best BS installation alternative with machine‐learning approaches as well as to estimate ROI value by changing the properties that affect the ROI value. For this purpose, the estimation performance of logistic regression, random forest, and XGBoost methods are compared and further strengthened by random forest hyperparameter optimization to provide the best performance. The model, with a success rate of 98.7% according to the
‐score, showed that it was a robust algorithm. The three most essential features for the ROI value are determined to be voice traffic, data traffic, and frequency cost. These parameters enable a review of the prediction results of telecommunications managers and planning specialists responsible for BS investment.
The reciprocal relations among self‐compassion, and depression among adolescents after the Jiuzhaigou earthquake: A three‐wave cross‐lagged study
Authors: Liu Aiyi , Xu Boya , Liu Mingxiao , Wang Wenchao , Wu Xinchun 
Published: March 2023

AbstractBackgroundPrevious cross‐sectional studies have examined the relationship between self‐compassion and depression. Although it is often implicitly assumed that self‐compassion may increase the vulnerability of an individual to depression, only a few studies have assessed whether self‐compassion is a cause or a consequence of depression or both.MethodTo examine such reciprocal effects, we assessed self‐compassion and depression via self‐report measures. At the baseline assessment (Time 1, T1), 450 students (M = 13.72, SD = 0.83, 54.2% females) participated 10 months after the Jiuzhaigou earthquake. We reassessed the T1 sample after 6‐ and 12‐month intervals. At Time 2 (T2) assessment, 398 (56.0% female participants) of the Wave 1 participants were retained, and at Time 3 (T3) assessment, 235 (52.5% female participants) of the T1 and T2 participants were retained.ResultsCross‐lagged analyses indicated that positive self‐compassion could significantly reduce subsequent depression. However, depression did not significantly predict later positive self‐compassion. Negative self‐compassion at T1 increased depression at T2, but negative self‐compassion at T2 did not significantly predict depression at T3. In addition, positive self‐compassion significantly reduced subsequent negative self‐compassion.ConclusionsPositive self‐compassion appears to protect adolescents against depression and maintain this protection over time, whereas negative self‐compassion may worsen depression in adolescents during the initial stages of traumatic events. Additionally, positive self‐compassion may decrease the level of negative self‐compassion.
Muscle stem cells contribute to long‐term tissue repletion following surgical sepsis
Authors: Schmitt Rebecca E. , Dasgupta Aneesha , Arneson‐Wissink Paige C. , Datta Srijani , Ducharme Alexandra M. , Doles Jason D. 
Published: March 2023

AbstractBackgroundOver the past decade, advances in sepsis identification and management have resulted in decreased sepsis mortality. This increase in survivorship has highlighted a new clinical obstacle: chronic critical illness (CCI), for which there are no effective treatment options. Up to half of sepsis survivors suffer from CCI, which can include multi‐organ dysfunction, chronic inflammation, muscle wasting, physical and mental disabilities, and enhanced frailty. These symptoms prevent survivors from returning to regular day‐to‐day activities and are directly associated with poor quality of life.MethodsMice were subjected to cecal ligation and puncture (CLP) with daily chronic stress (DCS) as an in vivo model to study sepsis late‐effects/sequelae on skeletal muscle components. Longitudinal monitoring was performed via magnetic resonance imaging, skeletal muscle and/or muscle stem cell (MuSCs) assays (e.g., post‐necropsy wet muscle weights, minimum Feret diameter measurements, in vitro MuSC proliferation and differentiation, number of regenerating myofibres and numbers of Pax7‐positive nuclei per myofibre), post‐sepsis whole muscle metabolomics and MuSC isolation and high‐content transcriptional profiling.ResultsWe report several findings supporting the hypothesis that MuSCs/muscle regeneration are critically involved in post‐sepsis muscle recovery. First, we show that genetic ablation of muscle stem cells (MuSCs) impairs post‐sepsis muscle recovery (maintenance of 5–8% average lean mass loss compared with controls). Second, we observe impaired MuSCs expansion capacity and morphological defects at 26 days post‐sepsis compared with control MuSCs (P < 0.001). Third, when subjected to an experimental muscle injury, sepsis‐recovered mice exhibited evidence of impaired muscle regeneration compared with non‐septic mice receiving the same muscle injury (CLP/DCS injured mean minimum Feret is 92.1% of control injured, P < 0.01). Fourth, we performed a longitudinal RNA sequencing study on MuSCs isolated from post‐sepsis mice and found clear transcriptional differences in all post‐sepsis samples compared with controls. At Day 28, CLP/DCS mice satellite cells have multiple altered metabolic pathways, such as oxidative phosphorylation, mitochondrial dysfunction, sirtuin signalling and oestrogen receptor signalling, compared with controls (P < 0.001).ConclusionsOur data show that MuSCs and muscle regeneration are required for effective post‐sepsis muscle recovery and that sepsis triggers morphological, functional, and transcriptional changes in MuSCs. Moving forward, we strive to leverage a more complete understanding of post‐sepsis MuSC/regenerative defects to identify and test novel therapies that promote muscle recovery and improve quality of life in sepsis survivors.