bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inside the treaty interpreter’s mind: An experimental linguistic approach to international law
Authors: Pirker Benedikt , Skoczeń Izabela 
Published: April 2023

AbstractOne particularly intense critical debate over interpretation in international law concerns the role of moral factors – specifically, the degree to which such factors influence legal interpretation, and how the law should deal with them. A formalist approach argues that moral considerations should be excluded as non-legal; a critical legal studies approach suggests they are an inevitable part of the functioning of international law and must therefore be acknowledged; and an inclusivist approach would suggest their influence is permissible, albeit only under certain circumstances. In this article, we are concerned with the question of whether moral factors influence interpretation at all, taking international treaties as the object of study. To address this question, we take a novel approach, proposing an experimental linguistic framework to test whether linguistic categorizations (originally developed for the analysis of everyday language) can be successfully applied to treaty interpretation, relying on both laypersons and experts as participants. Although some caveats must be made, the experiments deliver clear results: both groups are influenced by morals in their interpretation of international treaty norms. On this basis, we draw conclusions regarding (i) how the process of interpretation of international law operates; and (ii) what the institutions managing that process, such as courts, should factor-in when deliberating their decisions. By adopting this novel perspective, we also contribute to linguistic and experimental approaches to international law at the methodological level.
Ableism in the college of international lawyers: On disabling differences in the professional field
Authors: Kulamadayil Lys 
Published: April 2023

AbstractIn the wake of the #metoo and #blacklivesmatter movements, the masculine and ‘methodologically white’ nature of the core of the international legal profession has received renewed attention, and attempts to diversify it are well underway. Absent from the conversations that accompany such diversification efforts are reflections on the pervasiveness of ableism in the profession. Ableism describes implicit assumptions about the species-typical condition of the human body and the ways in which it interacts with the material and social world. The importance of ableism in excluding and marginalizing persons with disabling differences in international legal academia has widely been overlooked. This neglect simultaneously contributes to ableist re-productions of the profession and affects how international law understands and governs disability.
Clique-factors in graphs with sublinear -independence number
Authors: Han Jie , Hu Ping , Wang Guanghui , Yang Donglei 
Published: April 2023

Abstract
Given a graph

$G$

and an integer

$\ell \ge 2$

, we denote by

$\alpha _{\ell }(G)$

the maximum size of a

$K_{\ell }$

-free subset of vertices in

$V(G)$

. A recent question of Nenadov and Pehova asks for determining the best possible minimum degree conditions forcing clique-factors in

$n$

-vertex graphs

$G$

with

$\alpha _{\ell }(G) = o(n)$

, which can be seen as a Ramsey–Turán variant of the celebrated Hajnal–Szemerédi theorem. In this paper we find the asymptotical sharp minimum degree threshold for

$K_r$

-factors in

$n$

-vertex graphs

$G$

with

$\alpha _\ell (G)=n^{1-o(1)}$

for all

$r\ge \ell \ge 2$

.
Religious tolerance in the Arab Gulf states: Christian organizations, soft power, and the politics of sustaining the “family–state” beyond the rentier model
Authors: Monier Elizabeth 
Published: April 2023

Abstract
The states of the Arabian Gulf present a novel case for the examination of relations between authoritarian governance and Christian organizations. The economic clout of the Gulf states has been central to political stability and legitimacy but they are increasingly seeking to expand and consolidate the soft power and resilience through political and diplomatic initiatives. This article examines how the Christian organizations established in recent decades by large migrant communities are incorporated into this strategy and how they are responding. It argues that religious tolerance has formed a central discourse in governmental policies and narratives that construct the Gulf states as modern progressive nations, despite their unique political systems based mainly on constitutional monarchies with limited political participation. This constructs local Christian communities as a source of soft power, despite their position as a religious minority.
The Contribution of Anammox to Nitrogen Removal Is Greater in Bulk Soils Than in Rhizosphere Soils in Riparian Wetlands Along the Yangtze River
Authors: Deng Danli , Ding Bangjing , He Gang , Ji Mingfei , Yang Yuyi , Liu Guihua , Zhang Quanfa , Liu Wenzhi 
Published: April 2023

AbstractThe importance of denitrification and anaerobic ammonium oxidation (anammox) in removing nitrogen (N) from upland runoff has been well documented in riparian wetlands. However, the relative contributions of denitrification and anammox to N removal in the rhizosphere and non‐rhizosphere soils of riparian zones remain unclear. Here, we explored the denitrification and anammox rates in the rhizosphere and bulk soils (0–5 and 10–15 cm) of 39 riparian wetlands along the Yangtze River using the 15N isotope pairing technique. Additionally, we used a quantitative polymerase chain reaction assay to determine the abundance of soil denitrifying and anammox bacteria using nosZ and hzsB genes, respectively. The results showed that both denitrification and anammox rates were significantly higher in rhizosphere soils than in bulk soils, suggesting that the rhizosphere environment is favorable for N removal. The contribution of anammox constituted over half (62.53% ± 1.49%) of the N loss and was greater in bulk soils (68.57% ± 1.42%) than in rhizosphere soils (55.64% ± 2.42%). Higher nosZ and hzsB gene abundances were also observed in rhizosphere soils than in bulk soils. Denitrification and anammox rates were significantly regulated by edaphic properties, microbial abundance, and plant biomass. The structural equation model further revealed that soil pH and N availability could affect denitrification and anammox rates both directly and indirectly by altering nosZ and hzsB gene abundance. Overall, this study highlights that the rhizosphere is a control point for N removal and harbors more functional microbes than bulk soils. Therefore, revegetation may effectively enhance the N removal function of riparian wetlands along the Yangtze River.
On the Seasonal and Spatial Dependence of Extreme Warm Days in Antarctica
Authors: Xu Min , Yang Qinghua , Clem Kyle R. , Yu Lejiang , Hu Xiaoming 
Published: April 2023

AbstractThe spatial distribution of trends in temperature extremes over Antarctica remains largely unknown. Here we investigate the seasonal and spatial characteristics of extreme warm occurrence across Antarctica. The Antarctic inland areas show significant positive trends in the number of extreme warm days in austral spring and summer. The trends in the seasonal mean of daily maximum temperature show strong coherence with the trends in extreme warm occurrences. In addition, the long‐term longwave radiation, water vapor flux and regional atmospheric circulation changes are closely connected to the trends of extreme warm days in all seasons outside of summer; the summer longwave radiation and interior wind trends show little coherence with warm extreme trends, indicating other processes at play driving extreme warm days in summer.
Wave and Particle Analysis of Z‐Mode and O‐Mode Emission in the Jovian Inner Magnetosphere
Authors: Menietti J. D. , Yoon P. H. , Averkamp T. F. , Kurth W. S. , Faden J. B. , Allegrini F. , Kollmann P. , Bolton S. J. 
Published: April 2023

AbstractWe report some of the most intense Z‐mode and O‐mode observations obtained by the Juno spacecraft while in orbit about Jupiter in a low to mid‐latitude region near the inner edge of the Io torus. We have been able to estimate the density of the plasma in this region based on the lower frequency cutoff of the observed Z‐mode emission. The results are compatible with the electron density measurements of the Jovian Auroral Distributions Experiment (JADE), on board the Juno spacecraft, if we account for unmeasured cold plasma. Direction‐finding measurements indicate that the Z‐ and O‐mode emission have distinct source regions. We have also used the measured phase space density of the JADE and the Jupiter energetic particle detector instruments to calculate estimated local growth rates of the observed O‐mode and Z‐mode emission assuming a loss cone instability and quasilinear analysis. The results suggest the emissions were observed near, but not within, a source region, and the free energy source is consistent with a loss cone. We have thus carried out the quasilinear wave analysis of the assumed remote Z‐ and O‐mode wave growths. It is shown that the remotely generated waves, propagated through an inhomogeneous medium to the satellite location, may account for the observed wave characteristics. The importance of Z‐mode in accelerating electrons in the inner Jovian magnetosphere makes these new wave mode confirmations at Jupiter of particular interest.
Twelve-month effectiveness of telephone and SMS support to mothers with children aged 2 years in reducing children’s BMI: a randomized controlled trial
Authors: Wen Li Ming , Xu Huilan , Phongsavan Philayrath , Rissel Chris , Hayes Alison , Taki Sarah , Buchanan Limin , Simone Lisa , Moreton Renee , Baur Louise A. 
Published: April 2023

Abstract
Background/objectives
Few quality intervention studies have assessed whether a combined telephone and short message service (SMS) intervention to mothers is effective in reducing BMI and obesity risk behaviors of children at 3 years of age. This study aimed to assess effectiveness of telephone and SMS support in reducing children’s body mass index (BMI) and obesity risk behaviors.

Subjects/Methods
A randomized controlled trial (RCT) with 662 women of 2-year-old children (with the proportion of overweight and obesity being similar to the general population) was conducted in Sydney, Australia, March 2019–October 2020. The mothers in the intervention group received three telephone support sessions plus SMS messages and mailed-intervention-booklets over a 12 months period i.e., 24–26, 28–30, and 32–34 months of the child’s age. Mothers in the control group received usual care and two mailed booklets on information not related to the intervention. The primary outcome was child’s BMI at 3 years of age. Secondary outcomes were children’s dietary and activity behaviors. All outcome measures were based on mothers’ self-report using standardized tools due to COVID-19 pandemic restrictions.

Results
537 (81%) mothers completed the post-intervention assessment at 3 years with only 470 (71%) children having weight and height measures. Multiple imputation analysis showed no statistically significant difference in mean BMI between the groups. Children in the intervention group were more likely not to eat in front of the TV [AOR 1.79 (95% CI 1.17–2.73), P = 0.008], more likely to meet the dietary recommendations [AOR 1.73 (95% CI 0.99–3.02), P = 0.054] and meet the activity recommendations [AOR 1.72 (95% CI 1.11–2.67), P = 0.015] than those in the control group respectively. Among those with an annual household income (<AUD$80,000), the intervention was significantly associated with a lower mean BMI [16.26 (SD 2.22) kg.m−2] in the intervention group than [16.84 (SD 2.37)] in the control, a difference of −0.59 kg/m2 (95% CI: −1.15 to −0.03, P = 0.040).

Conclusions
A staged telephone and SMS support intervention to mothers with children aged 2 years was associated with improved dietary and activity behaviors. The intervention was also associated with reduced children’s BMI at age 3 years only for those from lower income households.

Trial registration
The trial is registered with the Australian Clinical Trial Registry (ACTRN12618001571268)
Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice
Authors: Yang Ximeng , Tohda Chihiro 
Published: April 2023

AbstractCentral nervous system axons have minimal capacity to regenerate in adult brains, hindering memory recovery in Alzheimer’s disease (AD). Although recent studies have shown that damaged axons sprouted in adult and AD mouse brains, long-distance axonal re-innervation to their targets has not been achieved. We selectively visualized axon-growing neurons in the neural circuit for memory formation, from the hippocampus to the prefrontal cortex, and showed that damaged axons successfully extended to their native projecting area in mouse models of AD (5XFAD) by administration of an axonal regenerative agent, diosgenin. In vivo transcriptome analysis detected the expression profile of axon-growing neurons directly isolated from the hippocampus of 5XFAD mice. Secreted protein acidic and rich in cysteine (SPARC) was the most expressed gene in axon-growing neurons. Neuron-specific overexpression of SPARC via adeno-associated virus serotype 9 delivery in the hippocampus recovered memory deficits and axonal projection to the prefrontal cortex in 5XFAD mice. DREADDs (Designer receptors exclusively activated by designer drugs) analyses revealed that SPARC overexpression-induced axonal growth in the 5XFAD mouse brain directly contributes to memory recovery. Elevated levels of SPARC on axonal membranes interact with extracellular rail-like collagen type I to promote axonal remodeling along their original tracings in primary cultured hippocampal neurons. These findings suggest that SPARC-driven axonal growth in the brain may be a promising therapeutic strategy for AD and other neurodegenerative diseases.
Marine picocyanobacterial PhnD1 shows specificity for various phosphorus sources but likely represents a constitutive inorganic phosphate transporter
Authors: Shah Bhumika S , Ford Benjamin A , Varkey Deepa , Mikolajek Halina , Orr Christian , Mykhaylyk Vitaliy , Owens Raymond J , Paulsen Ian T 
Published: April 2023

Abstract
Despite being fundamental to multiple biological processes, phosphorus (P) availability in marine environments is often growth-limiting, with generally low surface concentrations. Picocyanobacteria strains encode a putative ABC-type phosphite/phosphate/phosphonate transporter, phnDCE, thought to provide access to an alternative phosphorus pool. This, however, is paradoxical given most picocyanobacterial strains lack known phosphite degradation or carbon-phosphate lyase pathway to utilise alternate phosphorus pools. To understand the function of the PhnDCE transport system and its ecological consequences, we characterised the PhnD1 binding proteins from four distinct marine Synechococcus isolates (CC9311, CC9605, MITS9220, and WH8102). We show the Synechococcus PhnD1 proteins selectively bind phosphorus compounds with a stronger affinity for phosphite than for phosphate or methyl phosphonate. However, based on our comprehensive ligand screening and growth experiments showing Synechococcus strains WH8102 and MITS9220 cannot utilise phosphite or methylphosphonate as a sole phosphorus source, we hypothesise that the picocyanobacterial PhnDCE transporter is a constitutively expressed, medium-affinity phosphate transporter, and the measured affinity of PhnD1 to phosphite or methyl phosphonate is fortuitous. Our MITS9220_PhnD1 structure explains the comparatively lower affinity of picocyanobacterial PhnD1 for phosphate, resulting from a more limited H-bond network. We propose two possible physiological roles for PhnD1. First, it could function in phospholipid recycling, working together with the predicted phospholipase, TesA, and alkaline phosphatase. Second, by having multiple transporters for P (PhnDCE and Pst), picocyanobacteria could balance the need for rapid transport during transient episodes of higher P availability in the environment, with the need for efficient P utilisation in typical phosphate-deplete conditions.
Reduced inferior fronto-insular-thalamic activation during failed inhibition in young adults with combined ASD and ADHD compared to typically developing and pure disorder groups
Authors: Lukito Steve , O’Daly Owen G. , Lythgoe David J. , Hodsoll John , Maltezos Stefanos , Pitts Mark , Simonoff Emily , Rubia Katya 
Published: April 2023

AbstractAutism spectrum disorder (ASD) often co-occurs with attention-deficit/hyperactivity disorder (ADHD) and people with these conditions have frontostriatal functional atypicality during motor inhibition. We compared the neural and neurocognitive correlates of motor inhibition and performance monitoring in young adult males with “pure” and combined presentations with age-and sex-matched typically developing controls, to explore shared or disorder-specific atypicality. Males aged 20–27 years with typical development (TD; n = 22), ASD (n = 21), combined diagnoses ASD + ADHD (n = 23), and ADHD (n = 25) were compared using a modified tracking fMRI stop-signal task that measures motor inhibition and performance monitoring while controlling for selective attention. In addition, they performed a behavioural go/no-go task outside the scanner. While groups did not differ behaviourally during successful stop trials, the ASD + ADHD group relative to other groups had underactivation in typical performance monitoring regions of bilateral anterior insula/inferior frontal gyrus, right posterior thalamus, and right middle temporal gyrus/hippocampus during failed inhibition, which was associated with increased stop-signal reaction time. In the behavioural go/no-go task, both ADHD groups, with and without ASD, had significantly lower motor inhibition performance compared to TD controls. In conclusion, only young adult males with ASD + ADHD had neurofunctional atypicality in brain regions associated with performance monitoring, while inhibition difficulties on go/no-go task performance was shared with ADHD. The suggests that young people with ASD + ADHD are most severely impaired during motor inhibition tasks compared to ASD and ADHD but do not reflect a combination of the difficulties associated with the pure disorders.
NGS-defined measurable residual disease (MRD) after initial chemotherapy as a prognostic biomarker for acute myeloid leukemia
Authors: Li Yonghong , Solis-Ruiz Jose , Yang Fei , Long Nicola , Tong Carmen H. , Lacbawan Felicitas L. , Racke Frederick K. , Press Richard D. 
Published: April 2023

AbstractTreated AML patients often have measurable residual disease (MRD) due to persisting low-level clones. This study assessed whether residual post-treatment somatic mutations, detected by NGS, were significantly prognostic for subsequent clinical outcomes. AML patients (n = 128) underwent both pre-and post-treatment testing with the same 42-gene MRD-validated NGS assay. After induction, 59 (46%) patients were mutation-negative (0.0024 VAF detection limit) and 69 (54%) had ≥1 persisting NGS-detectable mutation. Compared with NGS-negative patients, NGS-positive patients had shorter overall survival (17 months versus median not reached; P = 0.004; hazard ratio = 2.2 [95% CI: 1.3–3.7]) and a shorter time to relapse (14 months versus median not reached; P = 0.014; HR = 1.9 [95% CI: 1.1–3.1]). Among 95 patients with a complete morphologic remission (CR), 43 (45%) were MRD-positive by NGS and 52 (55%) were MRD-negative. These MRD-positive CR patients had a shorter overall survival (16.8 months versus median not reached; P = 0.013; HR = 2.1 [95% CI: 1.2–3.9]) than did the MRD-negative CR patients. Post-treatment persisting MRD positivity, defined by the same NGS-based test used at diagnosis, is thus a more sensitive biomarker for low-level leukemic clones compared to traditional non-molecular methods and is prognostic of subsequent relapse and death.
Phase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumors
Authors: Luke Jason J. , Fakih Marwan , Schneider Charles , Chiorean E. Gabriela , Bendell Johanna , Kristeleit Rebecca , Kurzrock Razelle , Blagden Sarah P. , Brana Irene , Goff Laura W. , O’Hayer Kevin , Geschwindt Ryan , Smith Michael , Zhou Feng , Naing Aung 
Published: April 2023

Abstract
Background
Indoleamine 2,3-dioxygenase 1 (IDO1), an interferon-inducible enzyme, contributes to tumor immune intolerance. Immune checkpoint inhibition may increase interferon levels; combining IDO1 inhibition with immune checkpoint blockade represents an attractive strategy. Epigenetic agents trigger interferon responses and may serve as an immunotherapy priming method. We evaluated whether epigenetic therapy plus IDO1 inhibition and immune checkpoint blockade confers clinical benefit to patients with advanced solid tumors.

Methods
ECHO-206 was a Phase I/II study where treatment-experienced patients with advanced solid tumors (N = 70) received azacitidine plus an immunotherapy doublet (epacadostat [IDO1 inhibitor] and pembrolizumab). Sequencing of treatment was also assessed. Primary endpoints were safety/tolerability (Phase I), maximum tolerated dose (MTD) or pharmacologically active dose (PAD; Phase I), and investigator-assessed objective response rate (ORR; Phase II).

Results
In Phase I, no dose-limiting toxicities were reported, the MTD was not reached; a PAD was not determined. ORR was 5.7%, with four partial responses. The most common treatment-related adverse events (AEs) were fatigue (42.9%) and nausea (42.9%). Twelve (17.1%) patients experienced ≥1 fatal AE, one of which (asthenia) was treatment-related.

Conclusions
Although the azacitidine-epacadostat-pembrolizumab regimen was well tolerated, it was not associated with substantial clinical response in patients with advanced solid tumors previously exposed to immunotherapy.
The biophysical property of the limbal niche maintains stemness through YAP
Authors: Bhattacharya Swarnabh , Mukherjee Abhishek , Pisano Sabrina , Dimri Shalini , Knaane Eman , Altshuler Anna , Nasser Waseem , Dey Sunanda , Shi Lidan , Mizrahi Ido , Blum Noam , Jokel Ophir , Amitai-Lange Aya , Kaganovsky Anna , Mimouni Michael , Socea Sergiu , Midlij Mohamad , Tiosano Beatrice , Hasson Peleg , Feral Chloe , Wolfenson Haguy , Shalom-Feuerstein Ruby 
Published: April 2023

AbstractThe cell fate decisions of stem cells (SCs) largely depend on signals from their microenvironment (niche). However, very little is known about how biochemical niche cues control cell behavior in vivo. To address this question, we focused on the corneal epithelial SC model in which the SC niche, known as the limbus, is spatially segregated from the differentiation compartment. We report that the unique biomechanical property of the limbus supports the nuclear localization and function of Yes-associated protein (YAP), a putative mediator of the mechanotransduction pathway. Perturbation of tissue stiffness or YAP activity affects SC function as well as tissue integrity under homeostasis and significantly inhibited the regeneration of the SC population following SC depletion. In vitro experiments revealed that substrates with the rigidity of the corneal differentiation compartment inhibit nuclear YAP localization and induce differentiation, a mechanism that is mediated by the TGFβ−SMAD2/3 pathway. Taken together, these results indicate that SC sense biomechanical niche signals and that manipulation of mechano-sensory machinery or its downstream biochemical output may bear fruits in SC expansion for regenerative therapy.