bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome Assembly Resource and Annotation of Bursaphelenchus xylophilus TS-1, the Causal Agent of Pine Wilt Disease
Authors: Li Jie , Xiong Xiong , Ma Shencheng , Yu Chengming , Li Chuanrong , Li Yongxia , Liu Huixiang 
Published: April 2023

Pine wilt disease is a major biological disaster caused by Bursaphelenchus xylophilus. This study establishes a high-quality and well-annotated genome sequence of B. xylophilus strain TS-1 from Mountain Tai in Shandong province, China. The 75-Mbp assembly containing six chromosomes was established. These genome data represent a valuable new resource for future studies on B. xylophilus and the management of pine wilt disease. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Monitoring the Resolution of Acute Exacerbation of Airway Bronchoconstriction in an Asthma Attack Using Capnogram Waveforms
Authors: Shikama Mio , Yamamoto Miyuki , Osawa Itsuki , Sato Takuya , Hirayama Ichiro , Hayase Naoki , Matsubara Takehiro , Doi Kent 
Published: April 2023

BACKGROUND:
Patients with acute bronchospasm can show a distinct slope of the capnogram (“shark fin”) as a result of asynchronous alveolar excretion. Although the slope of the upward alveolar plateau (phase III) in the capnogram waveforms of non-intubated patients is known to help monitor the therapeutic response to acute bronchospasm, little is known about the significance of its slope among intubated patients. Therefore, we quantified the phase III slope of an intubated patient with acute asthma to investigate whether capnogram waveforms could be useful for identifying the response to antibronchospasm treatment in real time.

CASE SUMMARY:
The patient was a 53-year-old man who had a history of asthma. He presented to the emergency department with the primary complaint of respiratory distress. He was diagnosed with severe asthma attack and required invasive mechanical ventilation for 10 days, during which we quantified the phase III slope of the capnogram. The phase III slope decreased during treatment, with a significant reduction from the third to the fourth day; however, a significant decrease in end-tidal carbon dioxide (EtCO
2) was observed from the fifth to the sixth day. We found that the slope values decreased earlier than EtCO
2 reduction, although the absolute EtCO
2 values eventually decreased in response to antibronchospasm treatment.

CONCLUSION:
There were several reports that evaluated the phase III slope in non-intubated patients with asthma, but this is the first report measuring the phase III slope in an intubated patient over several days. Capnogram waveforms may serve as useful real-time indicators to monitor acute bronchospasm among mechanically ventilated patients.
Impact of Radial Arterial Location on Catheter Lifetime in ICU Surgical Intensive Care
Authors: Marie Damien , Dahyot-Fizelier Claire , Barrau Stéphanie , Boisson Matthieu , Frasca Denis , Jamet Angeline , Chauvet Stéphane , Ferrand Nathan , Pichot Amélie , Mimoz Olivier , Kerforne Thomas 
Published: April 2023

OBJECTIVES:
The use of arterial catheters is frequent in intensive care for hemodynamic monitoring of patients and for blood sampling, but they are often removed because of dysfunction. The primary objective is to compare the prevalence of radial arterial catheter dysfunction according to location in relation to the radiocarpal joint in intensive care patients.

DESIGN:
Prospective randomized, controlled, single-center study.

SETTING:
The surgical ICU of the university hospital of Poitiers in France.

PATIENTS:
From January 2016 to April 2017, all patients over 18 years old admitted to the surgical ICU and requiring an arterial catheter were included.

INTERVENTIONS:
Randomization into two groups: catheter placed near the wrist (within 4 cm of the radiocarpal joint) and catheter placed away the wrist. The primary endpoint was the prevalence of dysfunction. We also compared the prevalence of infection and colonization.

MEASUREMENTS AND MAIN RESULTS:
One hundred seven catheters were analyzed (14 failed placements with no difference between the two groups, and 16 catheters excluded for missing data), with 58 catheters in near the wrist group and 49 in away the wrist group. We did not find any significant difference in the number of catheter dysfunctions between the two groups (p = 0.56). The prevalence density of catheter dysfunction was 30.5 of 1,000 catheter days for near the wrist group versus 26.7 of 1,000 catheter days for away the wrist group. However, we observed a significant difference in terms of catheter-related infection in favor of away the wrist group (p = 0.04). In addition, distal positioning of the catheter was judged easier by the physicians.

CONCLUSIONS:
The distal or proximal position of the arterial catheter in the radial position has no influence on the occurrence of dysfunction. However, there may be an association with the prevalence of infections.
Duration of Breastfeeding and Supportive Paternal Caregiving in Early Childhood and the Potential Mediating Function of Maternal Caregiving
Authors: Feldman Julia S. , Natale Brianna N. , Shaw Daniel S. , Nordahl Kristin Berg , Janson Harald , Nærde Ane 
Published: April 2023

ABSTRACT:

Objective:
Supportive paternal caregiving is influenced by contextual factors, including maternal caregiving behaviors. Although longer periods of breastfeeding have been found to be associated with higher levels of maternal supportive parenting, it remains unknown whether the benefits of breastfeeding also extend to fathers' supportive caregiving. This study tested the indirect relation between the duration of breastfeeding and paternal supportive parenting through maternal supportive parenting.

Methods:
Participating families (N = 623) were from the Behavior Outlook Norwegian Developmental Study, a population-based longitudinal study in Southeast Norway. Path analysis was used to test associations between the duration of breastfeeding in the first year (parent report) and paternal supportive parenting (observed, 36 months), as potentially mediated by maternal supportive parenting (observed, 24 months).

Results:
After controlling for sociodemographic and birth factors, a longer duration of breastfeeding was indirectly associated with higher levels of observed paternal supportive parenting through maternal supportive parenting.

Conclusion:
The current findings suggest that the longer breastfeeding duration during the first year of life (i.e., infancy) might have important implications for both maternal and paternal supportive parenting in toddlerhood.
Internal Limiting Membrane Peeling in Patients Undergoing Vitrectomy for Tractional Retinal Detachment Secondary to Diabetic Retionpathy
Authors: Rush Ryan B. , Gomez Pedro Luis , Rush Sloan W. , Bastar Pedro Gomez 
Published: April 2023

AbstractPurpose:To assess the merits of internal limiting membrane (ILM) peeling during pars plana vitrectomy (PPV) in subjects with a tractional retinal detachment (TRD) secondary to proliferative diabetic retinopathy (PDR).Methods:One hundred and ninety one PDR subjects undergoing PPV for the principal indication of TRD were enrolled into this randomized controlled trial. Study subjects were intraoperatively randomized into one of the following treatment groups: Cohort A patients underwent ILM peeling, while Cohort B patients did not undergo ILM peeling. The main outcome was postsurgical epiretinal membrane (ERM) development at 6 months. The secondary outcome was attainment of ≥ 20/50 visual acuity (Snellen) at 6 months.Results:One hundred and thirty nine subjects underwent randomization and completed the study’s 6-month trial period. Cohort A had 3.1% (2/64) of subjects develop an ERM postoperatively, while Group B had 26.7% (20/75) of subjects develop an ERM postoperatively at 6 months (p<0.001). Attainment of ≥ 20/50 visual acuity (Snellen) at 6 months was found in 21.9% (14/64) of subjects in Cohort A and 9.3% (7/75) of subjects in Cohort B (p=0.039).Conclusions:PDR patients undergoing PPV for TRD have a lower frequency of postsurgical ERM formation and a greater likelihood of attaining ≥ 20/50 Snellen visual acuity at 6 months when ILM peeling is conducted. Specialists may consider peeling of the ILM during PPV an important surgical maneuver in this patient population.
Optical coherence tomography angiography in neuro-ophthalmology
Authors: Douglas Vivian Paraskevi , Douglas Konstantinos A.A. , Torun Nurhan 
Published: April 2023

Purpose of review
Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging technique, which provides depth resolved visualization of microvasculature of the retina and choroid. Although OCTA has been widely used for the evaluation of a number of retinal diseases, its use in the field of neuro-ophthalmology has been less studied. In this review, we provide an update on the utility of OCTA in neuro-ophthalmic conditions.

Recent findings
Peripapillary and macular microvasculature analyses have indicated that OCTA can be a promising tool for early detection of a number of neuro-ophthalmic diseases, differential diagnosis, and monitoring of disease progression. Recent studies have demonstrated that structural and functional impairment can develop at early stages in some conditions such as in multiple sclerosis and Alzheimer's disease even in the absence of overt clinical symptoms. Furthermore, this dye-less technique can be a valuable adjunct tool in the detection of complications commonly seen in some congenital entities such optic disc drusen.

Summary
Since its introduction, OCTA has emerged as an important imaging approach shedding light on unrevealed pathophysiological mechanisms of several ocular diseases. The use of OCTA as a biomarker in the field of neuro-ophthalmology has recently gained considerable attention with studies supporting its role in clinical setting while larger studies are warranted for correlating these findings with traditional diagnostic procedures and clinical features and outcomes.
Unplanned Extubation During Pediatric Cardiac Intensive Care: U.S. Multicenter Registry Study of Prevalence and Outcomes*
Authors: Perry Tanya , Klugman Darren , Schumacher Kurt , Banerjee Mousumi , Zhang Wenying , Bertrandt Rebecca , Wolovits Joshua S. , Murphy Lee D. , Misfeldt Andrew M. , Alten Jeffrey , Cooper David S. 
Published: April 2023

Objectives:
The epidemiology of unplanned extubations (UEs) and associated adverse outcomes in pediatric cardiac ICUs (CICU).

Design:
Registry data (August 2014 to October 2020).

Setting:
Forty-five Pediatric Cardiac Critical Care Consortium hospitals.

Patients:
Patients receiving mechanical ventilation (MV) via endotracheal tube (ETT).

Interventions:
None.

Measurements and Main Results:
Fifty-six thousand five hundred eight MV courses occurred in 36,696 patients, with a crude UE rate of 2.8%. In cardiac surgical patients, UE was associated with longer duration of MV, but we failed to find such association in medical patients. In both cohorts, UE was associated with younger age, being underweight, and airway anomaly. In multivariable logistic regression, airway anomaly was associated with UE in all patients. Younger age, higher Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery score category, longer duration of MV, and initial oral rather than nasal ETT are associated with UE in the surgical group, but we failed to find such associations in the medical group. UE was associated with a higher reintubation rate compared with elective extubation (26.8 vs 4.8%; odds ratio [OR], 7.35; 95% CI, 6.44–8.39; p < 0.0001) within 1 day of event. After excluding patients having redirection of care, UE was associated with at least three-fold greater odds for each of ventilator-associated pneumonia (VAP), cardiac arrest, and use of mechanical circulatory support (MCS). However, we failed to identify an association between UE and greater odds of mortality (1.2 vs 0.8%; OR, 1.48; 95% CI, 0.86–2.54; p = 0.15), but uncertainty remains.

Conclusions:
UE in CICU patients is associated with greater odds of cardiac arrest, VAP, and MCS. Cardiac medical and surgical patients in the CICU appear to have different explanatory factors associated with UE, and perhaps these may be modifiable and tested in future collaborative population research.
Team Approach to Delayed Pediatric Vestibular Diagnosis: A Case Study
Authors: Reaves Tyler , Bliss Rebecca , Chole Dana , Bridges Jeff 
Published: April 2023

Background and Purpose:
This report highlights the challenges of diagnosing pediatric vestibular neuritis following dental treatment and addressing fear avoidance behaviors.

Case Description:
An 11-year-old boy came to physical therapy with vestibular dysfunction following dental treatment that was unable to be diagnosed by emergency department staff. The participant received multispecialty treatment for 6 weeks.

Measurements:
Computerized Dynamic Posturography, Limits of Stability, Dizziness Handicap Inventory, Functional Gait Assessment, Dynamic Visual Acuity, and Modified Clinical Test of Sensory Interaction on Balance.

Outcomes:
Most notable improvements were seen in Limits of Stability and Computerized Dynamic Posturography. The participant made a full return to school and sport.

Conclusions:
The difficulty of pediatric vestibular neuritis diagnosis led to fear avoidance behaviors that were addressed by a collaborative specialty approach.

What This Adds to Evidence:
This is the first documented case of pediatric vestibular neuritis as a complication of a dental procedure with intervention focused on fear avoidance behaviors.
Dissemination of Remote Patient Monitoring: An Academic-Community Primary Care Partnership in South Carolina
Authors: Kirkland Elizabeth Barnhardt , Dericke Dawn , Bays Chloe Cooper , Wallinger Caroline , McElligott James , Slaughter Sabra , Moran William P. 
Published: April 2023

Context:
Remote patient monitoring (RPM) for diabetes and hypertension may reduce barriers to patient care, leading to improved disease control and decreased morbidity and mortality.

Program:
We describe the implementation of a community-academic partnership to improve diabetes and hypertension control for underserved populations using RPM.

Implementation:
In 2014, our academic medical center (AMC) began working with community health centers (CHCs) to implement a centrally monitored RPM program for patients with diabetes. AMC nurses recruited, trained, and supported community partners through regular communication. Community sites were responsible for enrollment, follow-up visits, and all treatment adjustments.

Evaluation:
More than 1350 patients have been enrolled across 19 counties and 16 predominantly rural CHCs. The majority of patients reported low annual household income and African American or Hispanic background. It took about 6 to 9 months of planning at each CHC prior to first enrolled patient. More than 30% of patients utilizing the newer device continued to transmit glucose readings regularly at week 52 of enrollment. Hemoglobin A1c data reporting was completed for more than 90% of patients at 6 and 12 months postenrollment.

Discussion:
Partnering of our AMC with CHCs enabled dissemination of an effective, inexpensive tool that engaged underserved populations in rural South Carolina and improved chronic disease management. We supported implementation of clinically effective diabetes RPM programs at several CHCs, reaching a large number of historically underserved and underresourced rural CHC patients with diabetes. We summarize key steps to achieving a successful, collaborative RPM program through AMC-CHC partnerships.
Susceptibility to 3BNC117 and 10-1074 in ART suppressed chronically infected persons
Authors: Tebas Pablo , Lynn Kenn , Azzoni Livio , Cocchella Giorgio , Papasavvas Emmanouil , Fair Matthew , Karanam Brijesh , Sharma Paridhima , Reeves Jacqueline D. , Petropoulos Christos J. , Lalley-Chareczko Linden , Kostman Jay R. , Short Willian , Mounzer Karam , Montaner Luis J. 
Published: April 2023

Objective:
The aim of this study was to assess the susceptibility of HIV to two HIV monoclonal antibodies (bnAbs), 3BNC117 and 10-1074, in individuals with chronically suppressed HIV infection.

Design:
The susceptibility of bnAbs was determined using the PhenoSense mAb Assay, which is a cell-based infectivity assay designed to assess the susceptibility of luciferase-reporter pseudovirions. This assay is the only CLIA/CAP compliant screening test specifically developed for evaluating bnAb susceptibility in people with HIV infection.

Method:
The susceptibility of luciferase-reporter pseudovirions, derived from HIV-1 envelope proteins obtained from PBMCs of 61 ART-suppressed individuals, to 3BNC117 and 10-1074 bnAbs was assessed using the PhenoSense mAb assay. Susceptibility was defined as an IC90 of <2.0 μg/ml and 1.5 μg/ml for 3BNC117 and 10-1074, respectively.

Results:
About half of the individuals who were chronically infected and virologically suppressed were found to harbor virus with reduced susceptibility to one or both of the tested bnAbs.

Conclusions:
The reduced combined susceptibility of 3BNC117 and 10-1074 highlights a potential limitation of using only two bnAbs for PREP or treatment. Further studies are needed to define and validate the clinical correlates of bnAb susceptibility.
New Contrast Media for K-Edge Imaging With Photon-Counting Detector CT
Authors: Jost Gregor , McDermott Michael , Gutjahr Ralf , Nowak Tristan , Schmidt Bernhard , Pietsch Hubertus 
Published: April 2023

AbstractThe recent technological developments in photon-counting detector computed tomography (PCD-CT) and the introduction of the first commercially available clinical PCD-CT unit open up new exciting opportunities for contrast media research. With PCD-CT, the efficacy of available iodine-based contrast media improves, allowing for a reduction of iodine dosage or, on the other hand, an improvement of image quality in low contrast indications. Virtual monoenergetic image reconstructions are routinely available and enable the virtual monoenergetic image energy to be adapted to the diagnostic task.A key property of PCD-CT is the ability of spectral separation in combination with improved material decomposition. Thus, the discrimination of contrast media from intrinsic or pathological tissues and the discrimination of 2 or more contrasting elements that characterize different tissues are attractive fields for contrast media research. For these approaches, K-edge imaging in combination with high atomic number elements such as the lanthanides, tungsten, tantalum, or bismuth plays a central role.The purpose of this article is to present an overview of innovative contrast media concepts that use high atomic number elements. The emphasis is on improving contrast enhancement for cardiovascular plaque imaging, stent visualization, and exploring new approaches using 2 contrasting elements. Along with the published research, new experimental findings with a contrast medium that incorporates tungsten are included.Both the literature review and the new experimental data demonstrate the great potential and feasibility for new contrast media to significantly increase diagnostic performance and to enable new clinical fields and indications in combination with PCD-CT.
The Effect of Adding Curcumin to Sertraline in the Treatment of Severe Major Depressive Disorder: A Randomized, Double-Blind Clinical Trial
Authors: Talaei Ali , Noori Reza , Rezaei Ardani Amir , Mohammadpour Amir Hooshang , Azimipoor Zohre , Afzaljavan Fahimeh 
Published: April 2023

Objectives
Major depressive disorder (MDD) is a chronic and debilitating disease influenced by inflammatory processes in the brain. Some evidence has represented the adding curcumin as a complementary regime to the standard medication in treating depressive symptoms. However, limited clinical trials have been conducted on the antidepressants effects of curcumin in MDD patients. Therefore, this study aimed to investigate the effectiveness of curcumin in the treatment of MDD.

Methods
In a randomized, double-blind clinical trial, 45 severe MDD patients referred to the psychiatric clinic of Ibn-e-Sina Hospital, Mashhad, Iran, during 2016 were selected. Patients were randomly divided into 2 groups who received sertraline plus curcumin or placebo at a dose of 40 mg/d for 8 weeks. The patients were evaluated using Beck Anxiety and Depression Surveys at the beginning of the study, fourth, and eighth weeks by a psychiatry resident. The data analyzed aiding SPSS software.

Results
While depression and anxiety significantly decreased during the 8 weeks of the study, there was no significant difference between the 2 groups (P > 0.05). However, the anxiety score was lower in the intervention group. Moreover, no severe adverse events were observed in all patients.

Conclusions
Adding 40 mg/d of SinaCurcumin to sertraline as a routine medical regimen did not improve the depression and anxiety levels in severe MDD patients. However, the anxiety score was lower in the intervention group than in the placebo receiver, which suggests curcumin may have a more effect on anxiety.
Are all underimmunized measles clusters equally critical?
Authors: Moon Sifat Afroj , Marathe Achla , Vullikanti Anil 
Published: April 2023

AbstractDisruptions in routine immunizations due to the COVID-19 pandemic have been a cause of significant concern for health organizations worldwide. This research develops a system science approach to examine the potential risk of geographical clustering of underimmunized individuals for an infectious disease like measles. We use an activity-based population network model and school immunization records to identify underimmunized clusters of zip codes in the Commonwealth of Virginia. Although Virginia has high vaccine coverage at the state level for measles, finer-scale investigation at the zip code level finds three statistically significant underimmunized clusters. To estimate the criticality of these clusters, a stochastic agent-based network epidemic model is used. Results show that different clusters can cause vastly different outbreaks in the region, depending on their size, location, and network characteristics. This research aims to understand why some underimmunized geographical clusters do not cause a large outbreak while others do. A detailed network analysis shows that it is not the average degree of the cluster or the percentage of underimmunized individuals in the cluster but the average eigenvector centrality of the cluster that is important in determining its potential risk.