bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semi‐supervised super‐resolution of diffusion‐weighted images based on multiple references
Authors: Guo Haotian , Wang Lihui , Gu Yulong , Zhang Jian , Zhu Yuemin 
Published: March 2023

AbstractSpatial resolution of diffusion tensor images is usually compromised to accelerate the acquisitions, and the state‐of‐the‐art (SOTA) image super‐resolution (SR) reconstruction methods are commonly based on supervised learning models. Considering that matched low‐resolution (LR) and high‐resolution (HR) diffusion‐weighted (DW) image pairs are not readily available, we propose a semi‐supervised DW image SR reconstruction method based on multiple references (MRSR) extracted from other subjects. In MRSR, the prior information of multiple HR reference images is migrated into a residual‐like network to assist SR reconstruction of DW images, and a CycleGAN‐based semi‐supervised strategy is used to train the network with 30% matched and 70% unmatched LR–HR image pairs. We evaluate the performance of the MRSR by comparing against SOTA methods on an HCP dataset in terms of the quality of reconstructed DW images and diffusion metrics. MRSR achieves the best performance, with the mean PSNR/SSIM of DW images being improved by at least 14.3%/28.8% and 1%/1.4% respectively relative to SOTA unsupervised and supervised learning methods, and with the fiber orientations deviating from the ground truth by about 6.28° on average, the RMSEs of fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity being 3.0%, 4.6%, 5.7% and 4.5% respectively relative to the ground truth. We validate the effectiveness of the proposed network structure, multiple‐reference and CycleGAN‐based semi‐supervised learning strategies for SR reconstruction of diffusion tensor images through the ablation studies. The proposed method allows us to achieve SR reconstruction for diffusion tensor images with a limited number of matched image pairs.
Tiered approach to evaluate the CYP3A victim and perpetrator drug–drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling
Authors: Mulford Darcy J. , Ramsden Diane , Zhang Liming , Michon Ingrid , Leifke Eckhard , Smith Neila , Jones Hannah M. , Scarpignato Carmelo 
Published: March 2023

AbstractVonoprazan is metabolized extensively through CYP3A and is an in vitro time‐dependent inhibitor of CYP3A. A tiered approach was applied to understand the CYP3A victim and perpetrator drug–drug interaction (DDI) potential for vonoprazan. Mechanistic static modeling suggested vonoprazan is a potential clinically relevant CYP3A inhibitor. Thus, a clinical study was conducted to evaluate the impact of vonoprazan on the exposure of oral midazolam, an index substrate for CYP3A. A physiologically‐based pharmacokinetic (PBPK) model for vonoprazan was also developed using in vitro data, drug‐ and system‐specific parameters, and clinical data and observations from a [14C] human absorption, distribution, metabolism, and excretion study. The PBPK model was refined and verified using data from a clinical DDI study with the strong CYP3A inhibitor, clarithromycin, to confirm the fraction metabolized by CYP3A, and the oral midazolam clinical DDI data assessing vonoprazan as a time‐dependent inhibitor of CYP3A. The verified PBPK model was applied to simulate the anticipated changes in vonoprazan exposure due to moderate and strong CYP3A inducers (efavirenz and rifampin, respectively). The clinical midazolam DDI study indicated weak inhibition of CYP3A, with a less than twofold increase in midazolam exposure. PBPK simulations projected a 50% to 80% reduction in vonoprazan exposure when administered concomitantly with moderate or strong CYP3A inducers. Based on these results, the vonoprazan label was revised and states that lower doses of sensitive CYP3A substrates with a narrow therapeutic index should be used when administered concomitantly with vonoprazan, and co‐administration with moderate and strong CYP3A inducers should be avoided.
Properties of Roselle and alizarin mixed loaded gelatin films as a pH‐sensing indicator for shrimp freshness monitoring
Authors: Moeinpour Farid , Mohseni‐Shahri Fatemeh S. 
Published: March 2023

AbstractAn intelligent pH‐sensing indicator containing Roselle (Hibiscus sabdariffa L.) (ROS) anthocyanin and alizarin (ALZ) was developed and characterized as on‐package indicator tags to check the shrimp freshness during the storing at 4°C. Fourier transform infrared (FT‐IR) analysis showed that ROS and ALZ were successfully immobilized in the gelatin–glycerol film‐forming substrate. The addition of various natural dyes enhanced the thickness and antioxidant action of the colourimetric film. To assess the response to changes in the pH, the colourimetric film was immersed in different buffers. Based on volatile amines secreted by shrimp, a test application of a colourimetric film containing natural dyes at a ratio of ROS:ALZ = 4:1 (v/v) was conducted in shrimp at 4°C. The findings indicated that the designed colourimetric film could produce various colours, which are thought to indicate the freshness and spoilage of packaged shrimp. Therefore, the target film can be utilized as a promising smart packaging material for monitoring the freshness of shrimp and aquatic products in real time.
Optimal condition‐based maintenance policy for systems with mutually dependent competing failure
Authors: Qi Faqun , Huang Meiqi 
Published: March 2023

AbstractIn this paper, a novel condition‐based maintenance (CBM) policy for systems with mutually dependent competing failure processes (DCFPs) is studied. The cumulative random shocks contribute to the increased rate of degradation, meanwhile, the hard failure threshold is reduced when the amount of degradation reaches a threshold. The degradation process is simulated by a non‐stationary Gamma process and random shocks are modeled as a homogeneous Poisson process. Preventive replacement (PR) and corrective replacement (CR) are accounted for in the developed maintenance strategy. The optimal periodic inspection interval, PR threshold, and the number of cumulative random shocks can be derived by minimizing the average long‐term maintenance cost rate. In the end, a numerical case is applied to demonstrate the availability of the developed models.
2D MoS2Nanosheets Induce Ferroptosis by Promoting NCOA4‐Dependent Ferritinophagy and Inhibiting Ferroportin
Authors: Liu Bingyan , Jiang Wei , Ye Yiyuan , Liu Ling , Wei Xiaoran , Zhang Qiu , Xing Baoshan 
Published: March 2023

AbstractThe exposure of MoS2nanosheets can cause cytotoxicity, which causes health risks and affects its medical applications. However, knowledge of the underlying molecular mechanisms remains limited. This study reports that MoS2nanosheets induces ferroptosis in vivo and in vitro, which is caused by the nanosheet themselves rather than by the dissolved ions. MoS2nanosheets induce ferroptosis in epithelial (BEAS‐2B) and macrophage (RAW264.7) cells due to nuclear receptor coactivator 4 (NCOA4)‐dependent excusive ferritinophagy and the inhibition of ferroportin‐1 (FPN). In this process, most of the MoS2nanosheets enter the cells via macropinocytosis and are localized to the lysosome, contributing to an increase in the lysosomal membrane permeability. At the same time, NCOA4‐dependent ferritinophagy is activated, and ferritin is degraded in the lysosome, which generates Fe2+.Fe2+leaks into the cytoplasm, leading to ferroptosis. Furthermore, the inhibition of FPN further aggravates the overload of Fe2+in the cell. It has also been observed that ferroptosis is increased in lung tissue in mouse models exposed to MoS2nanosheets. This work highlights a novel mechanism by which MoS2nanosheets induce ferroptosis by promoting NCOA4‐dependent ferritinophagy and inhibiting FPN, which could be of importance to elucidate the toxicity and identify the medical applications of 2D nanoparticles.
Numerical analysis on mechanical behavior of steel‐concrete composite beams under fire
Authors: Wang Wenjun , Jiang Binhui , Ding Fa‐xing , Wang Liping 
Published: March 2023

SummaryThis paper investigated the fire behavior of steel‐concrete composite beams (SCB) and partially encased steel‐concrete composite beams (PEB) through numerical analysis. The numerical models established by the software ABAQUS were verified against experimental results. Parametric studies were performed to study the influences of load ratio, strength of concrete and steel, width of concrete slab, size of steel beam, fire protection layer, and degree of shear connection on the fire behavior of SCB and PEB. The analysis results show that the deformation stages of SCB and PEB under fire both go through four stages: elastic, elastic–plastic, plastic small deformation, and plastic large deformation. The web of SCB experiences a tension–compression–tension process under fire, and the bottom flange of PEB may even change from tension to compression at a lower load ratio. The failure mode of PEB, whether the concrete is crushed, depends on the load ratio. When SCB fails, the concrete is crushed and only the bottom flange of the steel beam yields. Under various parameters, the fire resistance of SCB is about 22 min, while the fire resistance of PEB is 82–93 min under a load of 0.4. When the load ratio increases from 0.2 to 0.6, the fire resistance of SCB decreases by 8 min, while that of PEB decreases by 110 min. To meet class I fire resistance rating under a normal service load ratio of 0.4, additional measures for PEB are still required, and at least 15 mm of fire protection layer is required for the steel beam of SCB. Finally, considering the temperature internal fore, a coefficient related to the fire time was introduced to modify the formula of ultimate flexural capacity of SCB and PEB, which showed good accuracy.
Heavy metal contamination in the marine environment of Pekalongan, Indonesia: Spatial distribution and hydrodynamic modeling
Authors: Ismanto Aris , Hadibarata Tony , Widada Sugeng , Atmodjo Warsito , Satriadi Alfi , Siagian Hendry , Safinatunnajah Novia 
Published: March 2023

AbstractPollution in Pekalongan waters is one of the environmental problems caused by the industrial city. Batik industry, the most common activity at Pekalongan, uses a lot of water and generates a lot of effluent because it involves an aqueous process when dyeing fabric. This wastewater, contains heavy metal contaminants like hexavalent chromium (Cr+6), copper (Cu), and lead (Pb), generally finds its way to rivers that run across Pekalongan. The contamination level, spatial distribution, and transport simulation of copper (Cu) and chromium (Cr) in water were investigated in the Loji and Banger rivers in Pekalongan, Indonesia. A two‐dimensional hydrodynamic model was constructed to simulate heavy metal concentrations in marine environment of Pekalongan City, Indonesia. The model's kinetic processes comprised air exchange, transportation, and deposition. Thus, Cu concentrations were below Indonesia's threshold, but Cr, especially in the river and outlet river, exceeded it. Both rivers have 0.002 mg/L Cu. Since water freely flows at Banger River Estuary, Cr concentration reach the highest in both rivers, 0.1056 mg/L. The evaluation findings and the numerical Cu and Cr calculation model created in this work have important research ramifications for preventing and controlling heavy metal pollution.
Adipose‐derived mesenchymal stem cells secrete extracellular vesicles: A potential cell‐free therapy for canine renal ischaemia‐reperfusion injury
Authors: Liu Haifeng , Huang Liyuan , Chen Fuhao , Zhong Zhijun , Ma Xiaoping , Zhou Ziyao , Cao Suizhong , Shen Liuhong , Peng Guangneng 
Published: March 2023

AbstractBackgroundAdipose‐derived mesenchymal stem cells (ADMSCs) and their extracellular vesicles (EVs) are a promising source of therapies for ischaemia‐reperfusion (IR) because of their potent anti‐inflammatory and immunomodulatory properties.ObjectivesThe aims of this study were to explore the therapeutic efficacy and potential mechanism of ADMSC‐EVs in canine renal IR injury.MethodsMesenchymal stem cells (MSCs) and EVs were isolated and characterised for surface markers. A canine IR model administered with ADMSC‐EVs was used to evaluate therapeutic effects on inflammation, oxidative stress, mitochondrial damage and apoptosis.ResultsCD105, CD90 and beta integrin ITGB were positively expressed in MSCs, while CD63, CD9 and intramembrane marker TSG101 were positively expressed in EVs. Compared with the IR model group, there was less mitochondrial damage and reduction in quantity of mitochondria in the EV treatment group. Renal IR injury led to severe histopathological lesions and significant increases in biomarkers of renal function, inflammation and apoptosis, which were attenuated by the administration of ADMSC‐EVs.ConclusionsSecretion of EVs by ADMSCs exhibited therapeutic potential in renal IR injury and may lead to a cell‐free therapy for canine renal IR injury. These findings revealed that canine ADMSC‐EVs potently attenuate renal IR injury‐induced renal dysfunction, inflammation and apoptosis, possibly by reducing mitochondrial damage.
Preemptively planned en bloc resection of an extensive right adrenal pheochromocytoma involving the right hepatic division, caval thrombus and segmental caudal vena cava in a dog with Budd−Chiari‐like syndrome
Authors: Takeuchi Ryo , Ishigaki Kumiko , Yoshida Orie , Sakurai Naoki , Terai Kazuyuki , Heishima Tatsuya , Asano Kazushi 
Published: March 2023

AbstractBackgroundSurgical resection is the treatment of choice for canine adrenal pheochromocytomas (PHEOs). Information on en bloc resection of adrenal PHEO with tumour thrombus, right hepatic division and segmental caudal vena cava (CVC) running through the adrenal tumour and right hepatic division is limited.ObjectiveTo describe the preemptively planned en bloc resection of an extensive right adrenal PHEO involving the right hepatic division, the caval thrombus and the segmental CVC in a dog with Budd−Chiari‐like syndrome (BCLS).MethodsA 13‐year‐old castrated male miniature dachshund was referred for surgical treatment due to anorexia, lethargy and severe abdominal distension caused by abundant ascites. Preoperative computed tomography (CT) revealed a large mass in the right adrenal gland with a large caval thrombus obstructing the CVC and hepatic veins, which caused BCLS. Additionally, collateral vessels were formed between the CVC and azygos veins. No findings suggested obvious metastases. Based on CT findings, an en bloc resection of the adrenal tumour with caval thrombus, right hepatic division and segmental CVC was planned.ResultsThe preoperatively planned resection was feasible; the tumour was completely resected grossly. The operation time and total Pringle manoeuvre time were 162 min and 16 min 56 s, respectively. There was no postoperative hindlimb oedema, renal dysfunction, ascites or abdominal distention. The patient's clinical signs, including appetite, fully improved. Hospitalization lasted 16 days. However, the patient died on the 130th postoperative day due to suspected metastases and cachexia.ConclusionsEven in case of an extensive infiltration of adrenal PHEO causing BCLS, an en bloc resection might be successfully achieved based on the preoperative CT findings speculating the collateral vessels formed for caudal venous return.
The effects of melatonin on the concentrations of inflammatory cytokines and proteins, serotonin, cortisol and melatonin in ovariohysterectomised female dogs
Authors: Salavati Sina , Mogheiseh Asghar , Nazifi Saeed , Amiri Atefeh , Nikahval Behrooz 
Published: March 2023

AbstractBackgroundOvariohysterectomy (OHE) induces inflammation and stress in female dogs. The anti‐inflammatory effects of melatonin have been reported in several studies.ObjectivesThe goal of this study was to assess the effects of melatonin on the concentrations of melatonin, cortisol, serotonin, α‐1‐acid glycoprotein (AGP), serum amyloid A (SAA), c‐reactive protein (CRP), interleukin‐10 (IL‐10), interleukin‐8 (IL‐8), interleukin‐1β (IL‐1β) and tumour necrosis factor‐α (TNF‐α) before and after OHE.MethodsThe total number of animals was 25 and aligned in 5 groups. Fifteen dogs were divided into three groups (n = 5): melatonin, melatonin+anaesthesia and melatonin+OHE and received melatonin (0.3 mg/kg, p.o.) on days –1, 0, 1, 2 and 3. Ten dogs were assigned to the control and OHE groups (n = 5) without melatonin treatment. OHE and anaesthesia were performed on day 0. Blood samples were obtained via jugular vein on days –1, 1, 3 and 5.ResultsMelatonin and serotonin concentrations significantly increased in the melatonin, melatonin+OHE and melatonin+anaesthesia groups compared with the control group, while cortisol concentration decreased in the melatonin+OHE group compared with the OHE group. The concentrations of acute‐phase proteins (APPs) and inflammatory cytokines significantly increased after OHE. The CRP, SAA and IL‐10 concentrations decreased significantly in the melatonin+OHE group compared with the OHE group. The concentrations of cortisol, APPs and proinflammatory cytokines increased significantly in the melatonin+anaesthesia group compared with the melatonin group.ConclusionsThe oral administration of melatonin before and after OHE help controlling the high levels of inflammatory APPs, cytokines and cortisol induced by OHE in female dogs.
An Overture: A Historical Overview of Political and Cultural Antecedents of the Nordic School System and its Variety of Teacher Education Programmes
Authors: Elstad Eyvind 
Published: March 2023

AbstractTrade and contact between people in the northwest corner of Europe and other parts of the world can be traced far back in time. The attacks and raids of Vikings created terror in parts of Europe, but through Christianization, the people in the north gradually assimilated the values of the other European regions. The transnational Catholic church influenced the order of several societies. Schools in the Nordic region at first provided training for the priesthood. With the Reformation, the transnational influence of the Church was greatly weakened. In the 18th century, societal authorities introduced a new school model: mandatory public school for all. This public school helped spread literacy and more in-depth knowledge of Christianity. Over time, the idea emerged that schools should serve a broader purpose than spreading Christian knowledge; the need for teacher education was recognised as a logical consequence. Substantial improvements to the school system took place through trained teachers and the expansion of schools’ content. The changes in Nordic societies laid the foundation for and were influenced by improvements in the school system, indicating a renewal of the school systems. Teacher education evolved from a seminary-based education with many general education elements, to an extended education.
A First Look at Brand Indicators for Message Identification (BIMI)
Authors: Yajima Masanori , Chiba Daiki , Yoneya Yoshiro , Mori Tatsuya 
Published: March 2023

AbstractAs promising approaches to thwarting the damage caused by phishing emails, DNS-based email security mechanisms, such as the Sender Policy Framework (SPF), Domain-based Message Authentication, Reporting & Conformance (DMARC) and DNS-based Authentication of Named Entities (DANE), have been proposed and widely adopted. Nevertheless, the number of victims of phishing emails continues to increase, suggesting that there should be a mechanism for supporting end-users in correctly distinguishing such emails from legitimate emails. To address this problem, the standardization of Brand Indicators for Message Identification (BIMI) is underway. BIMI is a mechanism that helps an email recipient visually distinguish between legitimate and phishing emails. With Google officially supporting BIMI in July 2021, the approach shows signs of spreading worldwide. With these backgrounds, we conduct an extensive measurement of the adoption of BIMI and its configuration. The results of our measurement study revealed that, as of November 2022, 3,538 out of the one million most popular domain names have a set BIMI record, whereas only 396 (11%) of the BIMI-enabled domain names had valid logo images and verified mark certificates. The study also revealed the existence of several misconfigurations in such logo images and certificates.
Transformationen
Authors: Stübe Raphael 
Published: March 2023

ZusammenfassungÜber die Wiederkehr einer literarischen Romantik wurde um 1900 intensiv diskutiert. Welches Wissen genau mitschwingt, sobald von neuer Romantik und Neuromantik im zeitgenössischen Kontext die Rede ist, wird in diesem Kapitel diskursnah rekonstruiert. In einer ersten Phase (1890–1896) werden die Vorbilder und Voraussetzungen ausgemacht, die das Romantische erneut attraktiv machen: Neben Hermann Bahr sind Maurice Maeterlinck und Jens Peter Jacobsen dabei von entscheidender, internationaler Bedeutung. Erst in einer zweiten Phase (1896–1904) taucht das Schlagwort der ‚Neuromantik‘ auf, geprägt von dem Kulturvermittler Henri Albert, um vor allem im deutschsprachigen Raum Karriere zu machen: Ricarda Huch, Eugen Diederichs, Hugo von Hofmannsthal u. a. prägen den Begriff auf jeweils eigene Weise, wobei auch nationalpatriotische Stimmen Romantik als eine genuin deutsche Bewegung zu besetzen versuchen. Ablehnungen und Überwindungsversuche prägen schließlich die dritte und letzte Phase (1904–1910), in der mithilfe von kritischen Analysen zur Neoromantik eine weitere, nächste Phase der internationalen Kulturentwicklung eingeleitet werden soll. In einem überblickenden Fazit zeigt sich, dass die Debatten um neue Romantik insgesamt darum bemüht sind, das Ironische und Selbstreflexive an der Romantik abzustreifen und so eine Umwertung des Romantik-Begriffs für die 20. Jahrhundert vorbereiten.
Perioperative Ängste und die Angst vor dem Tod
Authors: Mavrogiorgou Paraskevi , Zogas Hannah , Zogas Georgios , Juckel Georg , Heuer Jan-Florian 
Published: March 2023

ZusammenfassungIn der Anästhesiologie wird man häufig mit Patienten konfrontiert, die unter perioperativen Ängsten und speziell der Angst vor dem Tod leiden, dies gilt jedoch nicht nur für die Anästhesiologie, sondern auch für die Psychiatrie und die Psychotherapie. Bislang ist die Literaturlage hierzu begrenzt, und daher werden diesem Übersichtsartikel die wichtigsten Arten von perioperativer Angst, diagnostische Aspekte sowie Risikofaktoren thematisiert. Anxiolytisch werden klassischerweise Benzodiazepine eingesetzt, in den letzten Jahren ist jedoch die präoperative Angst reduzierende Wirkung von z. B. supportiven Gesprächen, Akupunktur, Aromatherapie und Entspannungsverfahren stärker in den Fokus geraten, da Benzodiazepine unter anderen ein postoperatives Delir mit Zunahme von Morbidität und Mortalität fördern. Perioperative Ängste vor dem Tod sollten jedoch klinisch und wissenschaftlich verstärkt in den Blick genommen werden, um nicht nur die Patienten präoperativ besser versorgen, sondern auch um nachteilige Folgen im Verlauf von Operationen und danach reduzieren zu können.