bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the Distribution of Dominant Hard Ticks in Southeastern Coastal Areas of the Caspian Sea
Authors: Nabian Sedighe , Ebrahimzadeh Elahe , Farahi Abbas , Hanafi-Bojd Ahmad Ali 
Published: January 2025

Background: Ticks are hematophagous arthropods that have direct and indirect effects on hosts, including the trans­mission of pathogens. An environmental suitability study of some vector species of hard ticks was conducted using the MaxEnt model in the south-eastern region of the Caspian Sea in Iran.
Methods: The ticks were collected monthly (2014−2015) at 45 study sites covering different areas in terms of topogra­phy. Because most farms in the study area are traditionally engaged in sheep production and they are taken to pastures in the warm season, the ticks were sampled from herds of sheep.
Results: In total, 2410 hard ticks were collected and the vector species with wider distributions were considered for modelling. The areas under the curve for Hyalomma anatulicum, Hy. asiaticum, Hy. marginatum, Rhipicephalus bursa, Rh. sanguineus, and Rh. turanicus were 0.848, 0.762, 0.812, 0.772, 0.770 and 0.803, respectively. This means that tem­perature and precipitation were effective environmental variables for the prediction of appropriate regions for these tick species. The outputs of the models indicated that the western and south- western regions of Golestan Province provided the best niches for the presence of ticks.
Conclusion: The western regions of Golestan Province are potential habitats for tick-borne diseases in both livestock and humans and special attention should be focused on preventing the spread of such diseases in this region
Neutrophil Extracellular Traps Contribute to the Disease Severity of Dengue Virus Infection
Authors: Cucunawangsih Cucunawangsih , Sari-Wijaya Ratna , Hardjo-Lugito Nata Pratama , Suriapranata Ivet 
Published: January 2025

Background: The spectrum of dengue infection ranges from asymptomatic or mild to severe disease. The pathogenic mechanisms are not fully understood. A viral infection can induce the neutrophil extracellular traps (NETs), and the excessive NETs lead to increased vascular permeability, coagulopathy, and platelet dysfunction, a hallmark of severe dengue.
Methods: To evaluate the association of NETs formation with disease severity using a human public transcriptomic dataset (GSE17924) and clinical samples from dengue patients with different disease severity.
Results: Based on the transcriptomic analysis, the whole blood gene expression functional in neutrophil activities and NETs formation was upregulated with dengue disease severity. The serum concentration of citrullinated histone H3 (CitH3), a NETs marker, was measured in 28 dengue patients, of whom 18 classified as dengue fever (DF) and 10 as dengue hemorrhagic fever (DHF) grade 1 and 2. A significantly higher CitH3 concentration was found in DHF com­pared to DF patients. The level of CitH3 was negatively correlated with platelet counts.
Conclusion: Our results suggest NETs have contributed to the disease severity of dengue infection. Future studies on the predictive value of NETs markers and the potential NETs as a targeted therapy in dengue disease should be priori­tized
Educación estético-ambiental, etnografía y desarrollo humano: propuesta docente-educativa para rehumanizar los sentidos
Authors: Estévez Álvarez Lurima 
Published: January 2025

El texto establece nexos entre la Educación Estético-Ambiental (EEA), la Etnografía y la práctica estético-educativa que realizamos en el curso de extensión “La dimensión estético-ambiental en la ambientación curricular”, con alumnos del tercer año de la Licenciatura en Artes Visuales de la Universidade Federal do Rio Grande-FURG (Brasil, 2016), con el objetivo de dilucidar cómo los procesos de la Educación Estética vinculados a procesos de la Educación Ambiental contribuyen a una formación más integral de la personalidad. Para ello, efectuamos entrecruzamientos entre teóricos de la EEA, en especial, Pablo René Estévez, el principal referente en dicho campo; de la Etnografía y la Antropología (como Roberto Cardoso de Oliveira, Mariza Peirano y Carlos Rodriguez Brandão), y de la Teoría Bioecológica del Desarrollo Humano, de Urie Bronfenbrenner. Se ofrece un esbozo de los Talleres de Sensibilización Estético-Ambiental implementados, en función de una formación más integral de los sujetos en lo que concierne al vínculo hombre-naturaleza-sociedad, así como a la comprensión e interpretación de la realidad desde la perspectiva de la EEA.
Apropriação de discursos religiosos: do poder político à influência digital
Authors: Martins Tatiana , Borin Marta Rosa 
Published: January 2025

O presente ensaio apresentará um estudo comparativo entre o grupo The Family, organização que surge nos Estados Unidos em 1935 a qual reúne líderes de diferentes países e de diferentes crenças, e personalidades intituladas “pastores digitais”, mais precisamente os pentecostais, visando investigar a adaptação contemporânea do discurso fundamentalista religioso ao ambiente digital. No cenário atual, com as mudanças das dinâmicas sociais e o espaço ocupado pelas tecnologias digitais, esse modelo de controle simbólico foi ressignificado. O artigo explora como esses discursos religiosos são reconfigurados e adaptados às lógicas da internet, contudo, mantendo sua função central de exercer influência política e social sobre as massas, através de determinadas personalidades que apropriam-se de discursos religiosos, como a teologia da prosperidade e do domínio, integrando-os a práticas de coaching motivacional. Essa mescla resulta no que alguns estudos identificam como “teologia coaching”, uma abordagem que utiliza a fé como base para promover o sucesso pessoal e espiritual dos indivíduos, atraindo milhões de seguidores nas plataformas digitais. A análise traça um paralelo entre as estratégias de dominação e controle simbólico assumidas por The Family e as adotadas por figuras contemporâneas no ambiente digital, demonstrando como o poder simbólico no campo religioso é rearticulado para os tempos atuais.
NON-HORMONAL MALE CONTRACEPTIVES: A PROMISING PHARMACOLOGICAL ALTERNATIVE
Authors: De Medeiros Pereira Leonardo , Santos Taides , Silva Emilly , Costa Isadora , Silva Wellinton 
Published: January 2025

INTRODUCTION: The need to diversify the contraceptive methods usually used, due to the side effects resulting from their administration, is widely discussed. As male contraceptives are generally analogues of endogenous hormones1, the development of medications with milder side effects and reversible contraceptive efficacy has become necessary1,2,3,4. The pharmaceutical industry has therefore begun experimental research into enzymes and peptides that can inhibit the mechanisms of spermatogenesis or prevent fertilization without endocrine alterations1. OBJECTIVE: To present an overview of non-hormonal male contraceptives. METHODS: A qualitative and quantitative descriptive study was carried out, based on a search for scientific productions in the BVS and PubMed databases. To this end, the descriptors “Contraceptive Agents”, “Male”, “Serine Proteases” and “Serine Kinases” articulated by the Boolean operators “AND” and “OR” were used to filter out studies with the desired characteristics. In addition, the inclusion criteria were the length of time the articles had been written, up to five years, and the language used: English or Portuguese. A total of 36 studies were found. By analyzing the titles and abstracts of the texts, exclusion criteria were applied: duplicate, incomplete or disconnected articles were excluded. From this, 9 articles were selected for full reading and preparation of this review. RESULTS: The studies analyzed confirm that the use of hormonal contraceptive methods has major harmful effects¹. As non-hormonal male methods are still in the process of research and development, they have little uptake and are not in demand4. From this perspective, the main mechanisms of action of drugs with this objective are that they inhibit the activity of prostate-specific antigen (PSA), which is essential for semen liquefaction prior to fertilization2,3; protein kinase anchor 4, crucial for sperm motility4; serine/threonine kinase 33 (STK33)5 or testis-specific serine/threonine kinase 2 (TSSK2)1, both critical for spermatogenesis. DISCUSSION: The identified drugs represent alternative mechanisms for male contraception which, although still undergoing testing, are promising technologies for avoiding the side effects of hormone-based medications1, such as weight gain, decreased sexual performance, and mood changes2. These factors are essential for increasing adherence to these medications, despite their current limited availability on the market4,1. CONCLUSION: As analyzed, studies and experiments involving innovative contraceptive medications are on the rise. Considering that this is a field still undergoing refinement, eliminating dependence on hormonal or surgical methods relies on the continuation of ongoing research and the emergence of new, even more innovative studies.
Formulasi Sediaan Nanoemulsi Ekstrak Daun Jambu Biji (Psidium Guajava L.) Sebagai Bahan Aktif Pembuatan Serum Antioksidan
Authors: SHAFA ARIFAH ZHAFIRAH , Noor Fitri  
Published: January 2025

This research had been carried out on the formulation of guava leaf extract nanoemulsion as an active ingredient of antioxidant serum. The steps of this research include: (1) extraction by maceration; (2) Characterization and identification of extracts include phytochemical test, DPPH test, shear reagent test, and identification of compounds using LC-MS/MS; (2) formulation of nanoemulsion using Self-Nanoemulsifying Drug Delivery System (SNEDDS) method; (4) Nanoemulsion testing: stability test, antioxidant activity test using DPPH method, and irritation test, (5) nanoemulsion characterization which includes particle size, transmittance, pH, and viscosity. The results showed that: (1) the extract yields of the maceration method were 15,048%; (2) antioxidant compounds in Guava leaf extract were Candidate Mass C35H42O9, Candidate Mass C26H48O15, Candidate Mass C34H40O9, quercetin dan quercetin-3-O-α-L- arabinopyranoside; The IC50 of the macerated extract were 59,771 ± 1,357 ppm; (3) Nanoemulsions were made in 3 formulas (0.5; 1; and 1,5 g) with fixed variables of capryol 90, tween 20, and PEG 400 (1,5; 2,5; and 1); (4) stability test showed that only F1 was stable; the IC50 value of nanoemulsion is 509,039 ppm; and the F1 irritation test showed no erythema and edema; (5) The particle size of F1 was 168,2 nm with a transmittance value of 96,10%, a pH of 5,45, and a viscosity of 73,88 cP. So that the preparation of guava leaf extract nanoemulsion is not recommended as an active ingredient for making antioxidant serum.

Keywords : Guava Leaf, Nanoemulsion, Antioxidant, Serum, SNEDDS
Initiation of Z-fract Formula as a Bio-additive for Industrial Machine Efficiency Inisiasi Z-fract Formula sebagai Bio-aditif Efisiensi Mesin Industri
Authors: Fitri Noor , Mauludiyah Riskiyatul , Sukri Qomarudin , Syahputra Rahmat , Nurhuddah Ika Ila 
Published: January 2025

Sejak awal revolusi industri, bahan bakar minyak (BBM) telah menjadi sumber utama energi. Di Indonesia, konsumsi BBM meningkat 10 persen pada tahun 2016 yaitu 48,6 juta m3/tahun dibanding tahun 2015. Akan tetapi, peningkatan konsumsi bahan bakar tidak imbangi dengan peningkatan cadangan minyak bumi di Indonesia, yang diperkirakan akan habis pada 2050. Keterbatasan BBM, isu pemanasan global, dan masalah pencemaran lingkungan, telah mengarah pada penelitian mendalam mengenai penggunaan bahan bakar alternatif yang terbarukan dan berkelanjutan. Beberapa solusi telah ditawarkan oleh berbagai peneliti, salah satunya adalah penambahan bahan aditif dengan memanfaatkan sumber daya alam yang tersedia berlimpah di Indonesia dan non-edible seperti minyak atsiri.
Minyak atsiri merupakan minyak yang diperoleh dari bagian tanaman dengan berbagai teknik ekstraksi. Minyak atsiri memiliki titik uap yang rendah dan larut dalam solar. Selain itu, minyak atsiri mengandung berbagai macam senyawa kimia yang mengandung atom oksigen sehingga mampu menyempurnakan sistem pembakaran pada mesin diesel. Minyak atsiri berperan sebagai bioaditif untuk meningkatkan kualitas solar. Aditif bahan bakar adalah zat yang ditambahkan pada bahan bakar terutama bensin atau solar untuk meningkatkan sifat bahan bakarnya sehingga menghasilkan kinerja yang lebih baik. Ketika ditambahkan ke bahan bakar, mampu mengurangi emisi berbahaya seperti hidrokarbon (HC), partikel, emisi CO2 dan NOx. Selain itu digunakan untuk meningkatkan viskositas, antiknock, oktan, setana dan sifat aliran dingin (cold flow) dari bahan bakar serta meningkatkan stabilitas termal, kebersihan dan mencegah korosi mesin. Hasil penelitian menunjukkan bahwa minyak atsiri mampu menurunkan konsumsi pembakaran solar, menurunkan kadar emisi gas, dan mencegah karatan (deposit) pada mesin. Minyak atsiri serai wangi berpotensi dijadikan bioaditif karena senyawa utama sitronelal, geraniol dan sitronelol mengandung atom oksigen.
PT Arutmin Kintap telah melakukan pemberdayaan petani dan penyuling lokal dengan menanam serai wangi pada lahan bekas tambang seluas 10 Ha. PT Arutmin Kintap berencana menggunakan minyak atsiri serai wangi yang dihasilkan untuk produksi Z-fract Formula sebagai Bio-aditif efisiensi mesin industri bekerja sama dengan Universitas Islam Indonesia (UII). Formula bio-aditif Z-fract dibuat spesifik sesuai dengan mesin industri PT Arutmin. Langkah strategi yang akan dilakukan: (1) Workshop untuk petani atsiri untuk proses penanaman yang sesuai dengan Good Agricultural Practices (GAP) dalam upaya menjaga tersedianya bahan baku dan Produksi atsiri minyak serai wangi sesuai standar SNI; (2) Karakterisasi Minyak Serai Wangi yang telah diproduksi di Kintap; (3) Fraksinasi Minyak atsiri serai wangi; (4) Analisis Komposisi KimiaFraksi Minyak Serai Wangi.
Epitaxially-grown mode-tunable InP micro-ring lasers
Authors: Wong Wei Wen , Su Zhicheng , Wang Naiyin , Jagadish Chennupati , Tan Hark 
Published: January 2025

Abstract

In the near future, technological advances driven by the Fourth Industrial Revolution will boost the demand for integrated, power-efficient miniature lasers, which are important for optical data communications and advanced sensing applications. Although top-down fabricated III-V semiconductor micro-disk and micro-ring lasers have been shown to be efficient light sources, challenges such as etching-induced sidewall roughness and poor fabrication scalability have been limiting the potential for high-density on-chip integration. Here, we demonstrate InP micro-ring lasers fabricated with a highly-scalable epitaxial growth technique. With an optimized cavity design, the optically-pumped micro-ring lasers show efficient room-temperature lasing with lasing threshold of around 50 μJ cm-2 per pulse. Remarkably, through comprehensive modelling of the micro-ring laser, we demonstrate experimentally lasing mode engineering by tuning the vertical ring height. Our work is a major step toward realizing high-density monolithic integration of III-V miniature lasers on submicron-scale optoelectronic devices.
Femto-joule threshold reconfigurable all-optical nonlinear activators for picosecond spiking neural networks
Authors: Lin Hongtao , Liu Ruizhe , Wang Zijia , Zhong Chuyu , Chen Yan , Sun Boshu , Jian Jialing , Ma Hui , Gao Dawei , yang jianyi , Li Lan , Liu Kaihui , Hu Xiaoyong 
Published: January 2025

Abstract

Achieving optical computing with thousands of tera-operations per second per watt per square millimeter (TOPs/W/mm 2 ) is the key to surpassing electrical computing. This realization requires a breakthrough in the design of a new optical computing architecture and nonlinear activation functions. In this work, we propose an on-chip picosecond spiking optical neural network architecture, which can be expected to achieve 2.13×10 3 TOPs/mm2. By leveraging the Kerr effect of silicon and the saturable absorption of graphene, we designed an all-optical nonlinear activator based on a graphene-silicon integrated photonic crystal cavity. The ultralow threshold, high-speed, compact, and reconfigurable all-optical nonlinear activator could achieve a 4 fJ activation energy threshold, a 1.05 ps response time, and an ultrasmall size of 15 µm×10 µm. This device provides foundation blocks for the picosecond spiking optical neural network chip to achieve 106 TOPs/W/mm2 level optical computing.
High-Dimensional One-Shot Optical Field Compressive Sensing of Structured Light
Authors: Li Zhengyan , Hu Yaodan , Men Ting , Yan Mingdong , Tang Weiqi , Tang Haocheng , Fan Kuanjun 
Published: January 2025

Abstract

Light detection, no matter with human eyes or photodetectors, has long been limited by dimensions of obtained information. The term “dimension” refers to not only the three-dimensional (3D) space and the one-dimensional (1D) time, but also physical quantities completely defining a light field such as amplitude, phase, polarization, wavelength. Conventional light detections mainly capture two-dimensional (2D) transverse spatial intensity (amplitude), sometimes color or wavelength resolved, and great efforts have been taken to expand the optical sensing dimensions. As various types of novel structured light are enabled by advanced optical field manipulation approaches, full-dimensional optical sensing of arbitrary light fields is highly demanded, to resolve 3D spatiotemporal amplitude, phase, polarization, and wavelength information. Here we have proved the concept of high-dimensional one-shot optical field compressive sensing, resolving full-dimensional information of any light field. Besides ordinary light fields with spatiotemporally uniform polarization states, full-dimensional metrologies of complicated structured light are conducted, including optical vortices, radially and azimuthally polarized beams, polarization-gating fields. It is believed that this novel light detection framework can not only be further compactly implemented for high-dimensional one-shot light detectors, but also observe dynamic physical processes in real-time.
Observation of ultrametricity in photonic spin glasses
Authors: Ghofraniha Neda , Camara Josivanir Gomes , Ferretti Stefano , Gentilini Silvia , Silva Davinson Da , Conti Claudio 
Published: January 2025

Abstract

Hierarchy is the architecture of complex systems [1]. While Euclidean metric describes homogeneous and static systems, ultrametric geometry is for heterogeneous ensembles, hierarchic relations and dynamic contexts. Applications spread across all fields: communication technologies, information retrieval, clusterwise regression, analysis and synthesis of narratives and emotions [2].
The paradigmatic model describing complex systems is the spin glass theory, according to which the topology of the many metastable energy states is intrinsically ultrametric, as a consequence of the breaking of their symmetry [3]. Despite the importance, a real experimental observation of the universal behaviour has not yet been reported, due to the difficulty of finding a physical system that displays all the characteristics of spin glasses.
Random lasers have recently been proposed as excellent photonic counterparts of spin glasses with robust replica symmetry breaking features [4–6].
Here, we report the ultrametric structure of the replica space with clustered domains in random lasers, as predicted in the Parisi Ansatz [7]. We show that the number of the states forming isosceles triangles in the metric space increases through the laser threshold giving rise to the construction of a genealogical tree. Moreover, from the hierarchical topology of the states we obtain a direct observation of the complex energy landscape with evident breaking of ergodicity in the glassy regime. Our results, as well as being a milestone in complexity science, fuel the lively research into physical systems which in recent years has been leading to the creation of optical computers and quantum annealers [8–12].
Wirelessly-powered, Electronics-free Ultrasonic Tags for Continuous Wearable Health Monitoring in Epidermal and Ocular Applications
Authors: Beker Levent , Toymus Alp , Peker Süleyman , Atik Abdülkadir , Yener Umut , Albay Maide , Yılgör Emel , Yılgör İskender 
Published: January 2025

Abstract

Medical ultrasound is widely used, but the size, complexity, and need for trained operators currently restrict its use to clinical settings, limiting opportunities for continuous patient monitoring. Despite the rapid emergence of wearable ultrasound technologies in the research community, the common practice still requires wired connections to benchtop instruments. While a few fully wearable and integrated solutions do exist, complex ultrasound electronics are bulky and power-hungry, impeding unobtrusive sensing and seamless integration to patients’ daily lives. Here, we report miniaturized ultrasonic tags (US tags) in epidermal patch and contact lens formats that are entirely electronics-free, thereby enabling comfortable, continuous, and operator-free ultrasonic measurements at multiple anatomical sites, including bladder volume, axial eye length, and blood pressure. Ultrasonic transducers are coupled with mm-sized antennas to enable on-demand, wireless measurements without bulky electronics, when in proximity to an external coil. We demonstrate the versatility of the ultrasonic tags through in vitro, ex vivo and in vivo experiments for various monitoring applications, including bladder volume, axial eye length and blood pressure, paving the way for their widespread integration into future healthcare solutions.
The effect of treatment preferences on survival in early stage breast cancer in elderly patients over 65 years of age
Authors: Uguztemur Esma , Salim Derya Kivrak 
Published: January 2025

Abstract

Background
The increasing incidence and mortality of breast cancer with age remains a major health concern, particularly in the elderly population. However, the under-representation of older patients in clinical trials complicates our understanding of the characteristics of this population. In this retrospective study, we evaluated breast cancer patients aged 65 years and older with early-stage hormone receptor-positive, HER2-negative disease.
Method
A total of 157 patients were included in the study. We compared groups who received postoperative chemotherapy or hormonal therapy, and evaluated several clinical and pathological factors.Factors affecting relapse-free survival (RFS) and overall survival (OS) were evaluated.
Results
Our results showed a lower overall survival in the hormone therapy group compared to the chemotherapy group. However, this difference suggested the influence of not only the preference for non-aggressive treatments, but also the effect of comorbidities and life expectancy. Analysis of the causes of death showed that coronary heart disease was prominent in the hormone therapy group, suggesting that most deaths were due to causes other than breast cancer recurrence.
Conclusions
Our results highlight the importance of considering overall health and life expectancy when deciding on treatment options for advanced breast cancer patients. In addition, findings suggesting that aggressive treatments in older patients may provide limited benefit and reduce quality of life emphasise the need for more personalised treatment strategies in this population.