bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan E-modul Flipbook berbasis Infografis pada Mata Pelajaran IPS SISWA Kelas VII di SMPN 05 Samarinda
Authors: Salsabila Safira , Sudarman Sudarman , Riyadi Riyo 
Published: August 2023

Penelitian ini bertujuan dalam mengembangkan bahan ajar e-modul flipbook berbasis infografis pada mata pelajaran IPS kelas VII untuk menguji tingkat kelayakan bahan ajar dan respon siswa kelas VII A di SMPN 05 Samarinda. Jenis penelitian ini menggunakan Research & Development (R&D) dengan menggunakan model 4D (Define, design, development, disseminate). Hasil penelitian menunjukkan, tingkat kelayakan bahan ajar e-modul flipbook berbasis infografis (1) penilaian oleh ahli materi dengan jumlah skor 42,5 termasuk dalam kategori “Sangat Layak” dengan presentase kelayakan 85%. (2) hasil penilaian oleh ahli media dengan jumlah total skor 66 termasuk ke dalam kategori “Sangat Layak” dengan presentase kelayakan 88%. (3) hasil penilaian kelompok kecil dengan jumlah total skor 46,4 termasuk ke dalam kategori “Sangat Layak” dengan presentase kelayakan 92,8%. (4) hasil penilaian kelompok besar memperoleh total skor 45,11 termasuk dalam kategori ”Sangat Layak” dalam presentase kelayakan 90,2%. Kesimpulannya, bahan ajar e-modul flipbook berbasis infografis “layak” digunakan sebagai sumber pembelajaran.
Biowaiver as a Bioequivalence Study Option
Authors: Volkova E. A. , Medvedev Yu. V. , Fisher E. N. , Shohin I. E. 
Published: August 2023

SCIENTIFIC RELEVANCE.Biowaiver is a procedure for establishing the bioequivalence of generic and reference products withoutin vivostudies. Regulatory requirements for this procedure, as described in a variety of documents, differ in certain features and aspects. These differences need to be analysed.AIM.The aim was to compare international and Russian regulatory approaches to the Biopharmaceutics Classification System-based biowaivers, provide recommendations on comparative dissolution testing, and outline opportunities for streamlining the regulatory framework of the Eurasian Economic Union (EAEU).DISCUSSION.In this article, the authors analyse biowaiver requirements and describe procedures for assessing the permeability and pH-dependent solubility of medicines, comparing dissolution profiles in various media that simulate the gastrointestinal environment, and interpreting test results. This paper shows the role of excipients in the solubility and permeability of an active substance.CONCLUSIONS.The authors recommend a methodological approach to the biowaiver procedure for replacingin vivobioequivalence studies within vitrotests under the current EAEU regulatory framework and list the characteristics of medicines that limit the applicability of the procedure. In conclusion, this article provides a rationale for harmonising the existing guidelines and requirements.
चुम्बा समुदायको जीवन संस्कार : वर्तमान अवस्था
Authors: Gurung Nir Bahadur 
Published: August 2023

यो लेखको प्रमुख उद्देश्य चुम्बा समुदायको जीवन संस्कार सम्बन्धी दार्शनिक, सामाजिक, सांस्कृतिक तथा आर्थिक दृष्टिकोणले वर्तमान अवस्थालाई उजागर गर्नु हो। हिमाली उपत्यका बौद्ध संस्कृतिले सम्पन्न क्षेत्र हो। चुम उपत्यका त्यस्तै बौद्ध सम्पदाले सम्पन्न उपत्यका हो । यो अध्ययन वर्णनात्मक ढाँचामा गरिएको गुणात्मक प्रकृतिको अध्ययन हो। यसमा निगमनात्मक विधि अपनाइएको छ । यसमा प्रयोग गरिएका तथ्याङ्क प्राथमिक स्रोतबाट प्रत्यक्ष अवलोकन, अन्तर्वार्ता जस्ता विधिद्वारा सङ्कलन गरिएका छन् । पुस्तक, अनुसन्धान प्रतिवेदन, अनुसन्धानमूलक लेख, संस्थागत प्रतिवेदन जस्ता द्वितीयक स्रोतहरूबाट पनि तथ्याङ्कहरू लिइएका छन् । सञ्चार प्रविधि, सडक, यातायात, शिक्षाको विकास तथा सामाजिक गतिशीलता, बसाइसराइ, विश्वव्यापीकरणको चुनौतिको बावजुद पनि चुम्बाहरूले आफ्नो जीवन संस्कारलाई समय सापेक्ष परीवर्तनका साथै निरन्तरतालाई पनि कायम राख्दै आएको कुरा यस अध्ययनको निष्कर्ष हो।
Pengaruh Layanan Bimbingan Kelompok dengan Tekhnik Self Management untuk Mengurangi Perilaku Shopaholic Online Shop pada Santri Kelas 6 Madin di Pesantren Ngashor
Authors: Rosida Devi Yulivatur 
Published: August 2023

Penelitian inii untuk menurunkan perilaku shopaholic online shop pada santri kelas 6 madin pesantren ngashor Gumukmas Jember, Dengan menggunakan teknik purposive sampling. Banyak santriwati yang royal karena gaya hidup mereka yang bergengsi, sehingga mereka tidak bisa mengontrol dirinya untuk membeli barang-barang yang diinginkan. penelitian ini menggunakan eksperimen yaitu quasi eksperimen model desain One-Group pretestposttest design. Hasil dari penelitian menunjukkan data hasil uji Wilcoxon dengan hasil Sig. (-2 tailed) yang menyatakan yaitu 0,018, lebih kecil dari 0,025 yang artinya uji Wilcoxon dinyatakan diterima. Dari hasil tersebut bisa disimpulkan jika terdapat pengaruh dari layanan bimbingan kelompok menggunakan Tekhnik Self-Management untuk mengurangi perilaku shopaholic online shop pada santri kelas 6 madin dipesantren ngashor Gumukmas Jember.
Surgical management of brain metastasis from ovarian cancer: a systematic review and case series
Authors: Costello Meredith C. , Venigalla Greeshma , Merenzon Martín A. , Bhatia Shovan , Morell Alexis A. , Daggubati Lekhaj , Luther Evan , Shah Ashish H. , Komotar Ricardo J. , Ivan Michael E. 
Published: August 2023

OBJECTIVE
Ovarian cancer is a rare origin of brain metastasis (BM), with an incidence of only 1%–3%. Consequently, the literature is sparse, and no treatment consensus guideline is available for ovarian BM. The authors conducted a systematic review of ovarian BM and performed a combined pooled cohort survival analysis with their case series.

METHODS
A systematic review of PubMed, Scopus, and Web of Science consistent with PRISMA guidelines along with an institutional retrospective chart review was conducted. Inclusion criteria for the systematic review included patients with confirmed BM and primary ovarian cancer, reported perioperative complications and outcomes, differentiated histology, and explicitly reported individual patient data. Reviews, commentaries, technical notes, and articles without English-language translations were excluded. The Newcastle-Ottawa Quality Assessment Scale was used independently by the first and second authors to assess the quality of each article. The authors performed univariate and multivariate analyses of several survival prognostic factors. Kaplan-Meier curves were generated for significant prognostic factors in the univariate analysis.

RESULTS
A total of 48 patients with individual data across 34 studies and 8 patients from the authors’ institution were included. All patients (n = 56) underwent resection for BM; 83.9% received adjuvant radiotherapy following surgery and 41.1% of patients received adjuvant chemotherapy. The median progression-free survival was 12 months (range 2–43 months). The median overall survival was 9 months (range 1–49 months). On univariate analysis, a single BM and no extracranial metastasis conferred a survival benefit, while clear cell carcinoma as the primary histology corresponded to worsened OS. Multivariable analysis showed that age > 50 years (p = 0.002) and > 1 BM (p < 0.001) were risk factors for poor prognosis. Protective factors included the addition of the following multimodal adjuvant therapy with surgery: radiotherapy (p = 0.002), chemotherapy and radiotherapy (p = 0.005), and stereotactic radiosurgery (p = 0.002).

CONCLUSIONS
Although the scarcity of published individual patient data hinders the determination of optimal management, the authors’ analysis highlights that multimodal therapies, a single cranial lesion, and age < 50 years are associated with increased survival for patients with ovarian BMs.
Comparison of preoperative versus postoperative treatment dosimetry plans of single-fraction stereotactic radiosurgery for surgically resected brain metastases
Authors: Cheok Stephanie K. , Yu Cheng , Feng Jeffrey J. , Briggs Robert G. , Chow Frances , Hwang Lindsay , Ye Jason C. , Attenello Frank J. , Tran David , Chang Eric , Zada Gabriel 
Published: August 2023

OBJECTIVE
Stereotactic radiosurgery (SRS) for operative brain metastasis (BrM) is usually administered 1 to 6 weeks after resection. Preoperative versus postoperative timing of SRS delivery related to surgery remains a critical question, as a pattern of failure is the development of leptomeningeal disease (LMD) in as many as 35% of patients who undergo postoperative SRS or the occurrence of radiation necrosis. As they await level I clinical data from ongoing trials, the authors aimed to bridge the gap by comparing postoperative with simulated preoperative single-fraction SRS dosimetry plans for patients with surgically resected BrM.

METHODS
The authors queried their institutional database to retrospectively identify patients who underwent postoperative Gamma Knife SRS (GKSRS) after resection of BrM between January 2014 and January 2021. Exclusion criteria were prior radiation delivered to the lesion, age < 18 years, and prior diagnosis of LMD. Once identified, a simulated preoperative SRS plan was designed to treat the unresected BrM and compared with the standard postoperative treatment delivered to the resection cavity per Radiation Therapy Oncology Group (RTOG) 90–05 guidelines. Numerous comparisons between preoperative and postoperative GKSRS treatment parameters were then made using paired statistical analyses.

RESULTS
The authors’ cohort included 45 patients with a median age of 59 years who were treated with GKSRS after resection of a BrM. Primary cancer origins included colorectal cancer (27%), non–small cell lung cancer (22%), breast cancer (11%), melanoma (11%), and others (29%). The mean tumor and cavity volumes were 15.06 cm3 and 12.61 cm3, respectively. In a paired comparison, there was no significant difference in the planned treatment volumes between the two groups. When the authors compared the volume of surrounding brain that received 12 Gy or more (V12Gy), an important predictor of radiation necrosis, 64% of patient plans in the postoperative SRS group (29/45, p = 0.008) recorded greater V12 volumes. Preoperative plans were more conformal (p < 0.001) and exhibited sharper dose drop-off at the lesion margins (p = 0.0018) when compared with postoperative plans.

CONCLUSIONS
Comparison of simulated preoperative and delivered postoperative SRS plans administered to the BrM or resection cavity suggested that preoperative SRS allows for more highly conformal lesional coverage and sharper dose drop-off compared with postoperative plans. Furthermore, V12Gy was lower in the presurgical GKSRS plans, which may account for the decreased incidence of radiation necrosis seen in prior retrospective studies.
Epidemiology and survival outcomes of synchronous and metachronous brain metastases: a retrospective population-based study
Authors: Jiang Kelly , Parker Megan , Materi Joshua , Azad Tej D. , Kamson David O. , Kleinberg Lawrence , Ye Xiaobu , Rincon-Torroella Jordina , Bettegowda Chetan 
Published: August 2023

OBJECTIVE
Brain metastases (BMs) are the most common CNS tumors, yet their prevalence is difficult to determine. Most studies only report synchronous metastases, which make up a fraction of all BMs. The authors report the incidence and prognosis of patients with synchronous and metachronous BMs over a decade.

METHODS
Study data were obtained from the TriNetX Research Network. Patients were included if they had a primary cancer diagnosis and a BM diagnosis, with primary cancer occurring between January 1, 2013, and January 1, 2023. Metachronous BM was defined as BM diagnosed more than 2 months after the primary cancer. Cohorts were balanced by propensity score matching for age, extracranial metastasis, and antineoplastic or radiation therapy. Kaplan-Meier plots were used to evaluate survival differences between synchronous and metachronous BMs and associations with clinical conditions. A log-rank test was used to evaluate BM-free survival for metachronous BM and overall survival (OS) for all BMs. Hazard ratios and 95% CIs were calculated.

RESULTS
Of the 11,497,663 patients with 15 primary cancers identified, 300,863 (2.6%) developed BMs. BMs most commonly arose from lung and breast cancers and melanoma. Of all BMs, 113,827 (37.8%) presented synchronously and 187,036 (62.2%) presented metachronously. Lung and bronchial cancer had the highest metastasis rate (11.0%) and the highest synchronous presentation (51.0%). For metachronous presentations, the time from primary diagnosis to metastasis ranged from 1.3 to 2.5 years, averaging 1.8 years. Metachronous BM diagnosis was associated with longer survival over synchronous BM from primary diagnosis (11.54 vs 37.41 months, p < 0.0001), but shorter survival than extracranial metastases without BM (38.75 vs 69.18 months, p < 0.0001). Antineoplastic therapy prior to BM was associated with improved BM-free survival (4.46 vs 17.80 months, p < 0.0001) and OS (25.15 vs 42.26 months, p < 0.0001). Radiotherapy showed a similar effect that was statistically significant but modest for BM-free survival (5.25 vs 11.44 months, p < 0.0001) and OS (30.13 vs 32.82 months, p < 0.0001).

CONCLUSIONS
The majority of BMs present metachronously and arise within 2 years of primary cancer diagnosis. The substantial rate of BMs presenting within 6 months of primary cancer, especially liver, lung, and pancreatic cancer, may guide future recommendations on intracranial staging. Antineoplastic therapy prior to the development of BM may prolong the time before metastasis and improve survival. Further characterization of this population can better inform screening, prevention, and treatment efforts.
Genomic alterations associated with rapid progression of brain metastases
Authors: Uggerly Amalie S. V. , Cummins Daniel D. , Nguyen Minh P. , Saggi Satvir , Goldschmidt Ezequiel , Chang Edward F. , McDermott Michael W. , Berger Mitchel S. , Theodosopoulos Philip V. , Hervey-Jumper Shawn L. , Daras Mariza , Aghi Manish K. , Morshed Ramin A. 
Published: August 2023

OBJECTIVE
The aim of this study was to investigate associations between genomic alterations in resected brain metastases and rapid local and distant CNS recurrence identified at the time of postoperative adjuvant radiosurgery.

METHODS
This was a retrospective study on patients who underwent resection of intracranial brain metastases. Next-generation sequencing of more than 500 coding genes was performed on brain metastasis specimens. Postoperative and preradiosurgery MR images were compared to identify rapid recurrence. Genomic data were associated with rapid local and distant CNS recurrence of brain metastases using nominal regression analyses.

RESULTS
The cohort contained 92 patients with 92 brain metastases. Thirteen (14.1%) patients had a rapid local recurrence, and 64 (69.6%) patients had rapid distant CNS progression by the time of postoperative adjuvant radiosurgery, which occurred in a median time of 25 days (range 3–85 days) from surgery. RB1 and CTNNB1 mutations were seen in 8.7% and 9.8% of the cohort, respectively, and were associated with a significantly higher risk of rapid local recurrence (RB1: OR 13.6, 95% CI 2.0–92.39, p = 0.008; and CTNNB1: OR 11.97, 95% CI 2.25–63.78, p = 0.004) on multivariate analysis. No genes were found to be associated with rapid distant CNS progression. However, the presence of extracranial disease was significantly associated with a higher risk of rapid distant recurrence on multivariate analysis (OR 4.06, 95% CI 1.08–15.34, p = 0.039).

CONCLUSIONS
Genomic alterations in RB1 or CTNNB1 were associated with a significantly higher risk of rapid recurrence at the resection site. Although no genomic alterations were associated with rapid distant recurrence, having active extracranial disease was a risk factor for new lesions by the time of adjuvant radiotherapy after resection.
Stereotactic radiosurgery for distant brain metastases secondary to esthesioneuroblastoma: a single-institution series
Authors: Zamarud Aroosa , Yener Ulas , Yoo Kelly H. , Park David J. , Marianayagam Neelan J. , Ho Quoc-Anh , Pollom Erqi , Soltys Scott , Wang Lei , Chang Steven D. , Meola Antonio 
Published: August 2023

OBJECTIVE
Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare, malignant tumor of neuroectodermal origin that arises from the olfactory neuroepithelium. In this study the authors present the first series in the literature on distant brain metastases (BMs) secondary to ENB that were treated with stereotactic radiosurgery (SRS), to evaluate the safety and effectiveness of SRS for this indication.

METHODS
A retrospective analysis of clinical and radiological outcomes of patients with ENB who underwent CyberKnife (CK) SRS at a single center was conducted. The clinical and radiological outcomes of patients, including progression-free survival, overall survival, and local tumor control (LTC) were reported.

RESULTS
Between 2003 and 2022, 32 distant BMs in 8 patients were treated with CK SRS at Stanford University. The median patient age at BM diagnosis was 62 years (range 47–75 years). Among 32 lesions, 2 (6%) had previously been treated with surgery, whereas for all other lesions (30 [94%]), CK SRS was used as their primary treatment modality. The median target volume was 1.5 cm3 (range 0.09–21.54 cm3). CK SRS was delivered by a median marginal dose of 23 Gy (range 15–30 Gy) and a median of 3 fractions (range 1–5 fractions) to a median isodose line of 77% (range 70%–88%). The median biologically effective dose was 48 Gy (range 21–99.9 Gy) and the median follow-up was 30 months (range 3–95 months). The LTC at 1-, 2-, and 3-year follow-up was 86%, 65%, and 50%, respectively. The median progression-free survival and overall survival were 29 months (range 11–79 months) and 51 months (range 15–79 months), respectively. None of the patients presented adverse radiation effects.

CONCLUSIONS
In the authors’ experience, SRS provided excellent LTC without any adverse radiation effects for BMs secondary to ENB.
The role of the dura mater in cerebral metastases
Authors: Cozzi Francesca M. , Ampie Leonel , Laws Maxwell T. , Brown Desmond A. 
Published: August 2023

OBJECTIVE
The objective of this review was to describe the immunological changes that take place in the dura mater in response to metastatic disease that seeds the CNS. The authors hypothesized that the dura’s anatomy and resident immune cell population play a role in enabling metastasis to the brain and leptomeninges.

METHODS
An extensive literature search was conducted to identify evidence that supports the dura’s participation in metastasis to the CNS. The authors’ hypothesis was informed by a recent upsurge in studies that have investigated the dura’s role in metastatic development, CNS infections, and autoimmunity. They reviewed this literature as well as the use of immunotherapy in treating brain metastases and how these therapies change the meningeal immune landscape to overcome and reverse tumor-promoting immunosuppression.

RESULTS
Evidence suggests that the unique architecture and immune cell profile of the dura, compared with other immune compartments within the CNS, facilitate entry of metastatic tumor cells into the brain. Once these tumor cells penetrate the dural barrier, they propagate an immunosuppressive tumor microenvironment. Therefore, immunotherapy may serve to overcome this immunosuppressive environment and liberate proinflammatory immune cells in an effort to combat metastatic disease.

CONCLUSIONS
Within the next few years, the authors expect the addition of several more scientific studies into the literature that further underscore the dura as a chief participant and neuroanatomical barrier in neuro-oncology.
Microneurosurgical treatment of a small perimesencephalic pure pial arterial malformation: an under-recognized etiology of angiographically occult subarachnoid hemorrhage. Illustrative case
Authors: Sterner Robert C. , Greeneway Garret P. , Erginoglu Ufuk , Martínez Santos Jaime L. , Baskaya Mustafa K. 
Published: August 2023

BACKGROUND
Pial arterial malformations (PAMs) are rare vascular lesions consisting of dilated tortuous arteries without venous drainage. Current PAM understanding is limited by the lesion’s rarity, limited anatomopathological studies, and frequent misclassifications.

OBSERVATIONS
A 23-year-old male experienced two spontaneous subarachnoid hemorrhages (SAHs) over 6 months with initially unremarkable diagnostic cerebral angiograms. Magnetic resonance imaging (MRI) and angiography after the second SAH revealed a small perimesencephalic ovoid lesion within the left crural cistern, between the left superior and posterior cerebral arteries, appearing to be an exophytic cavernoma, a thrombosed aneurysm, or a hemorrhagic tumor. Microsurgical resection was achieved with a pterional craniotomy and anterior clinoidectomy. The resected lesion was characteristic of a pure PAM arising from superior cerebellar arterial branches.

LESSONS
Small pure PAMs can be deceitfully dynamic lesions causing episodes of hemorrhage, complete thrombosis (angiographically occult), recanalization, and rehemorrhage. Small thrombosed vascular malformations or aneurysms should be included in differential diagnoses of angiographically occult SAH. MRI can be diagnostic, but the true angioarchitecture can only be elucidated with microneurosurgery. The only definitive cure is removal. The microneurosurgical strategy should account for worst-case scenarios, provide adequate skull base exposures, and include bypass revascularization options when thrombosed aneurysms are encountered.
Audiobook-Mediated Learning: Investigating the Effects of ‘Storynory’ on Listening Skill
Authors: Purba Erlynda Christia , Yana Dewi , Putri Aulia , Edi Warno 
Published: August 2023

Audiobooks have received attention as learning media, and have been studied for language-learning benefits. However, Storynory audiobooks’ effects on listening skills are poorly studied. Understanding its effect can help educators and policymakers create effective instructional approaches. So, the objective of this study was to assess the potential impact of ‘Storynory’ audiobooks on the listening abilities. This study was carried out at SMA Kartini Batam on the odd semester of 2022/2023 academic year, employing a quantitative with quasi-experimental design. This study used two tests in collecting the data, namely a pre-test and a post-test. The study’s control group was comprised of 27 students, whereas the experimental group was composed of 19 students. The process of analyzing the data entailed the use of the Shapiro-Wilk technique to examine normality, the Levene Statistics test to evaluate homogeneity, and the t-test formula for the purpose of hypothesis testing. Based on the hypothesis testing, it was found that the t-value was 5.006, which exceeded the critical t-value of 2.101 (5.006 > 2.101). Therefore, the null hypothesis (H0) was rejected and the alternative hypothesis (Ha) was accepted. The findings indicate a moderate and statistically significant impact of Storynory implementation on the auditory aptitude of tenth-grade students at SMA Kartini Batam. This study provides evidence-based for teachers to improve listening instruction using Storynory Audiobook. Since this study was only carried out on a limited population, it is recommended that further researchers expand the population to provide a broader understanding of its effectiveness and generalization.