bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior hepatic resection: A simple and safe technique for reducing the antero‐posterior diameter of the liver graft for small pediatric recipients
Authors: Seda Neto João , Magalhães Costa Carolina , Pereira Fabio Payão , Pugliese Renata , Travassos Nathalia P. , Oliveira Caio M. , Vincenzi Rodrigo , Benavides Marcel R. , Roda Karina , Kondo Mário , Fonseca Eduardo A. 
Published: March 2023

AbstractBackgroundThe techniques involved in neonatal and infantile transplantation require approaches that can sculpt a left lateral segment (LLS) to the right shape and size and avoid large‐for‐size syndrome. The aim of this article is to describe the anterior hepatic resection (AHR) of the LLS in pediatric LDLT.MethodsA retrospective anatomical study of preoperative image studies, description of the technique for AHR, and short‐term results.ResultsThe AHR was performed in eight cases. All donors were male, with average age, BW, and BMI of 28.3 ± 5.9 years, 74.2 ± 9.3 kg, and 24.3 ± 2.6 kg/m2, respectively. Donors were discharged at an average of 3.6 ± 0.8 days. The median recipient age and BW at transplantation were 6.9 (2.7 to 11) months and 5.9 (3.9 to 8) kg, respectively, and the recipient‐to‐donor body weight ratio (RDBW) was <0.1 in all but one case. The mean percentage reduction in graft weight and in the antero‐posterior diameter were 33.2% ± 5.5% and 38.3% ± 12.6%, respectively. The average (SD) GRWR was 4.8% ± 1.7% before all the resections and 3.5% ± 1.0% after the procedures. Seven patients were primarily closed.ConclusionAfter LLS resection, a nonanatomical anterior resection of the LLS was accomplished without hilar vascular dissection to segments II/III. The final liver graft allowed primary abdominal wall closure in all but one patient, with meaningful adjustments in GRWR. AHR proved to be simple, safe, reproducible, and effective in the presented case series.
Work group diversity in professional football: An individual‐level approach to the effects of diversity in organizations
Authors: Lago Ignacio , Lago‐Peñas Carlos , Lago‐Peñas Santiago 
Published: March 2023

AbstractObjectiveAlthough there is a huge literature examining how diversity affects group performance, an important limitation is the lack of evidence at the employee level. This article tries to fill this gap. We focus on professional football given the high ethnic diversity of football squads, the nonexistence of language barriers to hire players, and the granularity of data.MethodsRelying on data from 1528 professional footballers joining a new club in the 2021–2022 season in five European countries, we run ordinary least squares cross‐sectional regressions with standard errors clustered by club.ResultsWe find that ethnic backgrounds do not make a difference in the performance of professional football players in their new clubs. However, newcomer players with a different ethnic background than natives in their new clubs do better the younger they are and when subgroup imbalance in the squad is high.ConclusionOur results support the approach integrating the social categorization and the information/decision‐making perspectives. From the players’ recruitment or renovation perspective, our results can help managers and coaches to make correct recruitment decisions.
Surfing to the political extremes: Digital media, social media, and policy attitude polarization
Authors: Gainous Jason , Wagner Kevin M. 
Published: March 2023

AbstractBackgroundCable news makes it possible for consumers to avoid information that challenges their predispositions, and the Internet makes it even easier. Cable news consumption is related to attitude extremity, but the extant literature is absent empirical examination of how the two may work together.ObjectivesThis study aims to contribute to our understanding of the relationship between media consumption and policy attitude extremity. In particular,, it asks how digital media consumption may combine with cable or traditional mass media to drive higher levels of polarization and attitude extremity.MethodsWe use American National Election Studies and data reduction methods to model and measure the gathering of political information to compare the relationship between different forms of media consumption and policy attitude extremity.ResultsOur results indicate that, independently, the consumption of both “partisan” cable news and “non‐partisan” political digital information have the same positive relationship to attitude extremity across four major issue domains (economy, federal spending, social issues, and foreign affairs) and that when combined into a single index, the relationship is stronger than their independent relationships. Finally, the results suggest that the combined effect is strongest among those who consume more liberal cable news.ConclusionOur high choice media environment contributes to the polarized climate in the United States today.
Differential modulation of Target of Rapamycin activity under single and combined iron and sulfur deficiency in tomato plants
Authors: Coppa Eleonora , Vigani Gianpiero , Aref Rasha , Savatin Daniel , Bigini Valentina , Hell Ruediger , Astolfi Stefania 
Published: March 2023

SUMMARYOver the past few decades, a close relationship between sulfur (S) and iron (Fe) in terms of functionality and nutrition was demonstrated in the tomato. However, very little is known about the regulatory mechanisms underlying S/Fe interactions. Recently, the potential role of citrate in plant adaptation to Fe deficiency and combined S and Fe deficiency has been described. It is known that an impaired organic acid metabolism may stimulate a retrograde signal, which has been proven to be linked to the Target of Rapamycin (TOR) signaling in yeast and animal cells. Recent reports provided evidence of TOR involvement in S nutrient sensing in plants. This suggestion prompted us to investigate whether TOR may play a role in the cross‐talk of signaling pathway occurring during plant adaptation to combined nutrient deficiency of Fe and S. Our results revealed that Fe deficiency elicited an increase of TOR activity associated with enhanced accumulation of citrate. In contrast, S deficiency resulted in decreased TOR activity and citrate accumulation. Interestingly, citrate accumulated in shoots of plants exposed to combined S/Fe deficiency to values between those found in Fe‐ and S‐deficient plants, again correlated with TOR activity level. Our results suggest that citrate might be involved in establishing a link between plant response to combined S/Fe deficiency and the TOR network.
Data-Driven Model Predictive Control for Roll-to-Roll Process Register Error
Authors: Shah Karan , He Anqi , Wang Zifeng , Du Xian , Jin Xiaoning 
Published: March 2023

Abstract
Roll-to-Roll (R2R) printing techniques are promising for high-volume continuous production of substrate-based products, as opposed to sheet-to-sheet (S2S) approach suited for low-volume work. However, meeting the tight alignment tolerance requirements of additive multi-layer printed electronics specified by device resolution that is usually at micrometer scale has become a major challenge in R2R flexible electronics printing, preventing the fabrication technology from being transferred from conventional S2S to high-speed R2R production. Print registration in a R2R process is to align successive print patterns on the flexible substrate and to ensure quality printed devices through effective control of various process variables. Conventional model-based control methods require an accurate web-handling dynamic model and real-time tension measurements to ensure control laws can be faithfully derived. For complex multistage R2R systems, physics-based state-space models are difficult to derive, and real-time tension measurements are not always acquirable. In this paper, we present a novel data-driven model predictive control (DD-MPC) method to minimize the multistage register errors effectively. We show that the DD-MPC can handle multi-input and multi-output systems and obtain the plant model from sensor data via an Eigensystem Realization Algorithm (ERA) and Observer Kalman filter identification (OKID) system identification method. In addition, the proposed control scheme works for systems with partially measurable system states.
Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019
Authors: Wang Rui , Li Zhaoqi , Liu Shaojun , Zhang Decai 
Published: March 2023

ObjectivesWe aimed to provide the most updated estimates on the global burden of inflammatory bowel disease (IBD) to improve management strategies.DesignWe extracted data from the Global Burden of Disease (GBD) 2019 database to evaluate IBD burden with different measures in 204 countries and territories from 1990 to 2019.SettingStudies from the GBD 2019 database generated by population-representative data sources identified through a literature review and research collaborations were included.ParticipantsPatients with an IBD diagnosis.OutcomesTotal numbers, age-standardised rates of prevalence, mortality and disability-adjusted life-years (DALYs), and their estimated annual percentage changes (EAPCs) were the main outcomes.ResultsIn 2019, there were approximately 4.9 million cases of IBD worldwide, with China and the USA having the highest number of cases (911 405 and 762 890 (66.9 and 245.3 cases per 100 000 people, respectively)). Between 1990 and 2019, the global age-standardised rates of prevalence, deaths and DALYs decreased (EAPCs=−0.66,–0.69 and −1.04, respectively). However, the age-standardised prevalence rate increased in 13 out of 21 GBD regions. A total of 147 out of 204 countries or territories experienced an increase in the age-standardised prevalence rate. From 1990 to 2019, IBD prevalent cases, deaths and DALYs were higher among females than among males. A higher Socio-demographic Index was associated with higher age-standardised prevalence rates.ConclusionsIBD will continue to be a major public health burden due to increasing numbers of prevalent cases, deaths and DALYs. The epidemiological trends and disease burden of IBD have changed dramatically at the regional and national levels, so understanding these changes would be beneficial for policy makers to tackle IBD.
Fundamental nursing care focusing on older people’s needs and continuity of long-term care: a scoping review protocol
Authors: Nordaunet Ole Martin , Gjevjon Edith Roth , Olsson Cecilia , Aagaard Hanne , Borglin Gunilla 
Published: March 2023

IntroductionKnowledge about long-term care services ability, regardless of if the service is home-based or facility-based, to provide an optimal and comprehensive fundamental nursing care (understood as focusing on physical, relational and psychosocial needs) consistently over time is sparse. Research into nursing indicates the presence of a discontinuous and fragmented healthcare service, and that fundamental nursing care such as mobilisation, nutrition and hygiene among older people (65 years and above) seems to be, regardless of reasons, systematically rationed by nursing staff. Thus, our scoping review aims to explore the published scientific literature on fundamental nursing care and continuity of care targeting older people’s needs while also describing identified nursing interventions with the same foci in a long-term care context.Methods and analysisThe upcoming scoping review will be conducted in accordance with Arksey and O’Malley’s methodological framework for scoping studies. Search strategies will be developed and adjusted to each database, for example, PubMed, CINAHL and PsychINFO. Searches will be limited to the years 2002–2023. Studies focusing our aim, regardless of study design, will be eligible for inclusion. Included studies will be quality assessed and data will be charted using an extraction form. Textual data will be presented through a thematic analysis and numerical data by a descriptive numerical analysis. This protocol adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol checklist.Ethics and disseminationThe upcoming scoping review will take into consideration ethical reporting in primary research as part of the quality assessment. The findings will be submitted to an open-access peer-reviewed journal. Under the Norwegian Act on Medical and Health-related Research, this study does not need ethical clearance by a regional ethical review authority as it will not generate any primary data or obtain sensitive data or biological samples.
FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
Authors: Canel Marta , Sławińska Aleksandra Dominika , Lonergan David W , Kallor Ashwin Adrian , Upstill-Goddard Rosie , Davidson Catherine , von Kriegsheim Alex , Biankin Andrew V , Byron Adam , Alfaro Javier , Serrels Alan 
Published: March 2023

ObjectiveImmunotherapy for the treatment of pancreatic ductal adenocarcinoma (PDAC) has shown limited efficacy. Poor CD8 T-cell infiltration, low neoantigen load and a highly immunosuppressive tumour microenvironment contribute to this lack of response. Here, we aimed to further investigate the immunoregulatory function of focal adhesion kinase (FAK) in PDAC, with specific emphasis on regulation of the type-II interferon response that is critical in promoting T-cell tumour recognition and effective immunosurveillance.DesignWe combined CRISPR, proteogenomics and transcriptomics with mechanistic experiments using a KrasG12Dp53R172Hmouse model of pancreatic cancer and validated findings using proteomic analysis of human patient-derived PDAC cell lines and analysis of publicly available human PDAC transcriptomics datasets.ResultsLoss of PDAC cell-intrinsic FAK signalling promotes expression of the immunoproteasome and Major Histocompatibility Complex class-I (MHC-I), resulting in increased antigen diversity and antigen presentation by FAK-/- PDAC cells. Regulation of the immunoproteasome by FAK is a critical determinant of this response, optimising the physicochemical properties of the peptide repertoire for high affinity binding to MHC-I. Expression of these pathways can be further amplified in a STAT1-dependent manner via co-depletion of FAK and STAT3, resulting in extensive infiltration of tumour-reactive CD8 T-cells and further restraint of tumour growth. FAK-dependent regulation of antigen processing and presentation is conserved between mouse and human PDAC, but is lost in cells/tumours with an extreme squamous phenotype.ConclusionTherapies aimed at FAK degradation may unlock additional therapeutic benefit for the treatment of PDAC through increasing antigen diversity and promoting antigen presentation.
Early neurological deterioration in patients with minor stroke due to isolated M2 occlusion undergoing medical management: a retrospective multicenter study
Authors: Broccolini Aldobrando , Brunetti Valerio , Colò Francesca , Alexandre Andrea M , Valente Iacopo , Falcou Anne , Frisullo Giovanni , Pedicelli Alessandro , Scarcia Luca , Scala Irene , Rizzo Pier Andrea , Bellavia Simone , Camilli Arianna , Milonia Luca , Piano Mariangela , Macera Antonio , Commodaro Christian , Ruggiero Maria , Da Ros Valerio , Bellini Luigi , Lazzarotti Guido A , Cosottini Mirco , Caragliano Armando A , Vinci Sergio L , Gabrieli Joseph D , Causin Francesco , Panni Pietro , Roveri Luisa , Limbucci Nicola , Arba Francesco , Pileggi Marco , Bianco Giovanni , Romano Daniele G , Frauenfelder Giulia , Semeraro Vittorio , Ganimede Maria P , Lozupone Emilio , Fasano Antonio , Lafe Elvis , Cavallini Anna , Russo Riccardo , Bergui Mauro , Calabresi Paolo , Della Marca Giacomo 
Published: March 2023

BackgroundPatients with minor stroke and M2 occlusion undergoing best medical management (BMM) may face early neurological deterioration (END) that can lead to poor long-term outcome. In case of END, rescue mechanical thrombectomy (rMT) seems beneficial. Our study aimed to define factors relevant to clinical outcome in patients undergoing BMM with the possibility of rMT on END, and find predictors of END.MethodsPatients with M2 occlusion and a baseline National Institutes of Health Stroke Scale (NIHSS) score≤5 that received either BMM only or rMT on END after BMM were extracted from the databases of 16 comprehensive stroke centers. Clinical outcome measures were a 90-day modified Rankin Scale (mRS) score of 0–1 or 0–2, and occurrence of END.ResultsAmong 10 169 consecutive patients with large vessel occlusion admitted between 2016 and 2021, 208 patients were available for analysis. END was reported in 87 patients that were therefore all subjected to rMT. In a logistic regression model, END (OR 3.386, 95% CI 1.428 to 8.032), baseline NIHSS score (OR 1.362, 95% CI 1.004 to 1.848) and a pre-event mRS score=1 (OR 3.226, 95% CI 1.229 to 8.465) were associated with unfavorable outcome. In patients with END, successful rMT was associated with favorable outcome (OR 4.549, 95% CI 1.098 to 18.851). Among baseline clinical and neuroradiological features, presence of atrial fibrillation was a predictor of END (OR 3.547, 95% CI 1.014 to 12.406).ConclusionPatients with minor stroke due to M2 occlusion and atrial fibrillation should be closely monitored for possible worsening during BMM and, in this case, promptly considered for rMT.
Searching for doubly charmed tetraquark candidates $$T_{cc}$$ and $$T_{cc\bar{s}}$$ in $$B_c$$ decays
Authors: Li Yuan , He Ying-Bo , Liu Xiao-Hai , Chen Baoyi , Ke Hong-Wei 
Published: March 2023

AbstractIn this work, we propose to search for the exotic doubly charmed meson $$T_{cc}^+$$

T

cc

+

and its analog $$T_{cc\bar{s}}^+$$

T

c
c

s

¯

+

in $$B_c^+$$

B
c
+

decays, which provide a good environment for the formation of the exotic state containing double charm quarks. Within the molecular scheme, the production of $$T_{cc}^+$$

T

cc

+

and $$T_{cc\bar{s}}^+$$

T

c
c

s

¯

+

through various rescattering processes with different intermediate states are investigated. For the moderate values of model parameters, the branching ratios of $$B_c^+$$

B
c
+

decaying into $$T_{cc}^+ \bar{D}^{0}$$

T

cc

+

D

¯

0

, $$T_{cc}^+ \bar{D}^{*0}$$

T

cc

+

D

¯

∗
0

, $$T_{cc\bar{s}}^+ \bar{D}^{0}$$

T

c
c

s

¯

+

D

¯

0

and $$T_{cc\bar{s}}^+ \bar{D}^{*0}$$

T

c
c

s

¯

+

D

¯

∗
0

are estimated to be of the order of $$10^{-7}$$

10

-
7

, $$10^{-5}$$

10

-
5

, $$10^{-6}$$

10

-
6

and $$10^{-4}$$

10

-
4

, respectively, which may be tested by future experiments.
Das sieht ja ganz anders aus, wie fühlst du dich denn? Teaching Modal Particles ja and denn with the Queer Eye Germany series: a didactic model based on a Descriptive Format
Authors: Aquino Marceli Cherchiglia 
Published: March 2023

This article proposes a linguistically based framework that can be used for the teaching of Modal Particles (MPs) using contextualized examples of authentic interactions from the Netflix's series Queer Eye Germany. For the description of MPs ja and denn we employ the Descriptive Format (Diewald et al. 2017), an interlinguistic schematic table which provides a definition of the morphological, syntactic, semantic and pragmatic characteristics of MPs. The format provides a linguistic framework for the development of a didactic material for teaching MPs, that is divided into three stages (Ende et al. 2013): introduction, elaboration and production. Therefore, the activities of the didactic model will be carried out in two phases: (i) the description of the formal and pragmatic characteristics of MPs ja and denn through the Descriptive Format; (ii) the elaboration of a didactic sequence with reception and production tasks using occurrences of MPs in authentic communicative contexts. This proposal aims to fill gaps in the teaching of MPs that takes into account a metalinguistic reflection (Aquino 2020), by which students can critically reflect on linguistic norms and the sociocultural reality of the target as well as of their own language.
Leptomeningeal Collateral Status by Signal Variance in Perfusion Magnetic Resonance Imaging: Association With Initial Stroke Severity and Early Functional Outcome After Thrombectomy
Authors: Helwig Niklas , Seker Fatih , Möhlenbruch Markus A. , Deichmann Ralf , Nöth Ulrike , Gracien René‐Maxime , Hattingen Elke , Wagner Marlies , Seiler Alexander 
Published: March 2023

BackgroundCollaterals are the main determinants of the severity of cerebral ischemia and control the pace of the ischemic tissue damage in acute ischemic stroke. Assessment of collateral status remains a major challenge in stroke imaging. We evaluated a signal variance–based collateral vessel index in perfusion‐weighted imaging (CVIPWI) in terms of its association with initial stroke severity, presence of a mismatch for endovascular thrombectomy (EVT), and early functional outcome in patients with large‐vessel occlusion.MethodsT2*‐weighted time series from dynamic susceptibility contrast perfusion imaging were processed to calculate the CVIPWI. Ischemic cores were segmented automatically on apparent diffusion coefficient maps. The relationship between collateral status and the fulfilment of mismatch criteria for EVT as well as the association between the CVIPWIand functional outcome in patients undergoing EVT were analyzed. Furthermore, spatial patterns of pial collateralization were investigated.ResultsA total of 156 patients with large‐vessel occlusion were included in the final analysis. Higher CVIPWIand thus better collateral supply was associated with lower baseline National Institutes of Health Stroke Scale and smaller baseline infarct volumes (P=0.022 andP=0.002, respectively), and the CVIPWIvaried significantly among groups according to fulfillment of mismatch criteria for EVT (P<0.001). In patients undergoing EVT (n=105), the CVIPWIwas an independent predictor of favorable functional outcome (modified Rankin scale score of 0–2) at discharge in multivariate analysis (P=0.031). In patients with EVT who had successful reperfusion (n=79), good collateral status was associated with a higher rate of early neurological improvement (P=0.026) and better functional outcome at discharge (P=0.04) in shift analysis.ConclusionSignal variance–based CVIPWIrepresents a semiquantitative and objective, thus observer‐independent parameter for direct assessment of collateral status with clinical relevance. Its use may inform clinical decision‐making and may be of interest for clinical stroke trials.
Personal Reflections on Some Early Work in Evolving Strategies in the Iterated Prisoner's Dilemma
Authors: Fogel David B. 
Published: March 2023

Abstract
On the occasion of the 30-year anniversary of the Evolutionary Computation journal, I was invited by Professor Hart to offer some reflections on the article on evolving behaviors in the iterated prisoner's dilemma that I contributed to its first issue in 1993. It's an honor to do so. I would like to thank Professor Ken De Jong, the journal's first editor-in-chief, for his vision in creating the journal, and the editors who have followed and maintained that vision. This article contains some personal reflections on the topic and the field as a whole.