bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient, Caregiver, and Clinician Perspectives on Core Components of Therapeutic Alliance for Adolescents and Young Adults With Advanced Cancer
Authors: Mastropolo Rosemarie , Altschuler Andrea , Brock Katharine E. , Casperson Mallory , Chao Chun R. , Fisher Lauren , Greenzang Katie A. , Kushi Lawrence H. , Lakin Joshua R. , Lefebvre Anna , Schwartz Corey M. , Shalman Dov M. , Wall Catherine B. , Wiener Lori , Mack Jennifer W. 
Published: August 2023

ImportanceThe patient-clinician therapeutic alliance is an important aspect of high-quality cancer care. However, components of the therapeutic alliance in adolescents and young adults (AYAs, aged 12-39 years) with cancer have not been defined.ObjectiveTo identify components of and barriers to the therapeutic alliance between AYAs, caregivers, and clinicians from the perspective of all key stakeholders.Design, Setting, and ParticipantsIn this qualitative study, semistructured in-depth interviews with patients, caregivers, and clinicians were conducted from 2018 to 2021 with no additional follow-up, with content analysis of resulting transcripts. Participants were recruited from Dana-Farber Cancer Institute, Kaiser Permanente Northern California, Kaiser Permanente Southern California, and an online cancer support community (Cactus Cancer Society). Eligible participants were English- or Spanish-speaking. Eligible patients were aged 12 to 39 years with stage IV or recurrent cancer. Eligible caregivers cared for an AYA living with advanced cancer or one who had died within 5 years. Eligible clinicians routinely provided care for AYAs with cancer.Main Outcomes and MeasuresPerspectives on therapeutic alliance.ResultsInterviews were conducted with 80 participants: 23 were patients (48% were female; 78% were White), 28 were caregivers (82% were female; 50% were White), and 29 were clinicians (69% were female; 45% were White). The mean (SD) age of patients was 29 (7.3) years. Interviews identified 6 components of therapeutic alliance: (1) compassion; (2) sense of connection; (3) clinician presence; (4) information sharing; (5) shared goals; and (6) individualization of care. While some domains were represented in prior models of therapeutic alliance, a unique domain was identified related to the need for individualization of the approach to care for AYA patients and their caregivers. Interviews also identified potential barriers to building the therapeutic alliance specific to the AYA population, including managing discordant needs between patients and caregivers and communication challenges at the end of life.Conclusions and RelevanceThis study identified core components and barriers to building therapeutic alliance in the AYA advanced cancer population from the perspective of all the key stakeholders in the relationship. A novel component highlighting the need for individualization was identified. This model enables a deeper understanding of how to build therapeutic alliance in the AYA advanced cancer population, which may guide clinician training and facilitate improved care for this vulnerable population.
High diagnostic performance of plasma and cerebrospinal fluid beta‐synuclein for sporadic Creutzfeldt–Jakob disease
Authors: Abu‐Rumeileh Samir , Halbgebauer Steffen , Bentivenga Giuseppe Mario , Barba Lorenzo , Baiardi Simone , Mastrangelo Andrea , Oeckl Patrick , Steinacker Petra , Mammana Angela , Capellari Sabina , Otto Markus , Parchi Piero 
Published: August 2023

ABSTRACTBeta‐synuclein is a promising cerebrospinal fluid and blood biomarker of synaptic damage. Here we analysed its accuracy in the discrimination between sporadic Creutzfeldt–Jakob disease (n = 150) and non‐prion rapidly progressive dementias (n = 106). In cerebrospinal fluid, beta‐synuclein performed better than protein 14‐3‐3 (AUC 0.95 vs. 0.89) and, to a lesser extent, than total tau (AUC 0.92). Further, the diagnostic value of plasma beta‐synuclein (AUC 0.91) outperformed that of plasma tau (AUC 0.79) and neurofilament light chain protein (AUC 0.65) and was comparable to that of cerebrospinal fluid biomarkers. Beta‐synuclein might represent the first highly accurate blood biomarker for the diagnosis of sporadic Creutzfeldt–Jakob disease.
Guselkumab Modulates Differentially Expressed Genes in Blood of Patients With Psoriatic Arthritis: Results from Two Phase 3, Randomized, Placebo‐Controlled Trials
Authors: Siebert Stefan , Sweet Kristen M. , Ritchlin Christopher T. , Hsia Elizabeth C. , Kollmeier Alexa P. , Xu Xie L. , Seridi Loqmane , Song Qingxuan , Gao Sheng , Chen Warner , Miron Michelle 
Published: August 2023

ObjectiveTo evaluate gene expression in blood of patients with psoriatic arthritis (PsA) versus healthy controls and identify changes associated with guselkumab treatment.MethodsWhole blood transcriptome profiling via paired‐end RNA sequencing was conducted using samples from DISCOVER‐1 and DISCOVER‐2 at baseline (n = 673) and at weeks 4 and 24 from a representative subgroup that received placebo or guselkumab (n = 227 [longitudinal PsA cohort]). Baseline samples were compared with demographically matched healthy controls (n = 21). Guselkumab‐mediated changes in gene expression were assessed in participants from the longitudinal PsA cohort who did versus did not achieve at least 20% improvement in American College of Rheumatology response criteria (ACR20) or at least 75% improvement in Psoriasis Area and Severity Index (PASI75). Differential gene expression was analyzed using edgeR.ResultsAt baseline, 355 upregulated and 314 downregulated genes (PsA‐associated genes) were identified in patients with PsA versus healthy controls. Upregulated genes were related to neutrophil, mononuclear cell, and CD11b+ gene sets. No cell type–specific gene sets were identified among downregulated genes. Most PsA‐associated genes were modulated by guselkumab treatment. At week 24, genes downregulated by guselkumab were enriched with neutrophil, monocyte, eosinophil, and macrophage gene sets; genes upregulated by guselkumab were enriched with B cell, T cell, and natural killer cell gene sets. Reductions in expression of upregulated PsA‐associated gene sets were more pronounced in ACR20 and PASI75 responders than in nonresponders.ConclusionThese findings suggest a dysregulation of immune cell profiles in blood from patients in the baseline PsA cohort that approached levels in healthy controls after guselkumab treatment.
Elucidating the Role of Chalcogenide‐Based Interface Passivators in Enhancing the Stability of Perovskite Solar Cells
Authors: Sadhu Anupam , Guo Yuanyuan , Salim Teddy , Sun Qingde , Mhaisalkar Subodh G. , Sum Tze Chien , Wong Lydia H. 
Published: August 2023

AbstractChalcogenide‐based Lewis bases are widely used in perovskite solar cells (PSCs) due to their effectiveness in passivating Pb2+ and Pb0‐related defects. However, the underlying principles governing their defect passivation and the relative efficacy of different chalcogen elements remain poorly understood. This study evaluates the effectiveness of oxygen, sulfur, and selenium‐based interface passivator molecules in enhancing the stability and power conversion efficiency (PCE) of perovskite solar cell devices. The hard and soft acid and base (HSAB) principle has been utilized here to gain insights into the defect passivation behavior of chalcogenide‐based molecules. The photoluminescence, ideality factor, and trap density measurements reveal that the sulfide and selenide‐passivated devices exhibit superior defect passivation compared to the oxide‐passivated control device. In terms of stability, the average T75 lifetime (time at which 75% of the initial PCE is retained) of the oxide, sulfide, and selenide passivated samples is 6%, 30%, and 50% higher compared to their un‐passivated counterparts. This enhanced stability with the sulfide and selenide‐based passivators can be attributed to their soft Lewis base nature, which resulted in stronger interaction with the Pb‐related defects, as evidenced by the density‐functional theory calculations and X‐Ray photoelectron spectroscopy study.
Hot‐Casting Strategy Empowers High‐Boiling Solvent‐Processed Organic Solar Cells with Over 18.5% Efficiency
Authors: Yang Chucheng , Jiang Mengyun , Wang Shanshan , Zhang Bao , Mao Peng , Woo Han Young , Zhang Fujun , Wang Jin‐liang , An Qiaoshi 
Published: August 2023

AbstractMost top‐rank organic solar cells (OSCs) are manufactured by the halogenated solvent chloroform, which possesses a narrow processing window due to its low‐boiling point. Herein, based on two high‐boiling solvents, halogenated solvent chlorobenzene (CB) and non‐halogenated green solvent ortho‐xylene (OX), preparing active layers with the hot solution is put forward to enhance the performance of the OSCs. In situ test and morphological characterization clarify that the hot‐casting strategy assists in the fast and synchronous molecular assembly of both donor and acceptor in the active layer, contributing to preferable donor/acceptor ratio, vertical phase separation, and molecular stacking, which is beneficial to charge generation and extraction. Based on the PM6:BO‐4Cl, the hot‐casting OSCs with a wide processing window achieve efficiencies of 18.03% in CB and 18.12% in OX, which are much higher than the devices processed with room temperature solution. Moreover, the hot‐casting devices with PM6:BTP‐eC9 deliver a remarkable fill factor of 80.31% and efficiency of 18.52% in OX, representing the record value among binary devices with green solvent. This work demonstrates a facile strategy to manipulate the molecular distribution and arrangement for boosting the efficiency of OSCs with high‐boiling solvents.
Room‐Temperature Chemoselective Hydrogenation of Nitroarene Over Atomic Metal–Nonmetal Catalytic Pair
Authors: Ding Jie , Li Fuhua , Zhang Jincheng , Qi Haifeng , Wei Zhiming , Su Chenliang , Yang Hong Bin , Zhai Yueming , Liu Bin 
Published: August 2023

AbstractConstructing atomic catalytic pair emerges as an attractive strategy to achieve better catalytic performance. Herein, an atomic Ir1─P1/NPG catalyst with asymmetric Ir─N2P1 sites that delivers superb activity and selectivity for hydrogenation of various functionalized nitrostyrene is reported. In the hydrogenation reaction of 3‐nitrostyrene, Ir1─P1/NPG (NPG refers to N, P‐codoped graphene) shows a turnover frequency of 1197 h−1, while the reaction cannot occur over Ir1/NG (NG refers to N‐doped graphene). Compared to Ir1/NG, the charge density of the Ir site in Ir1─P1/NPG is greatly elevated, which is conducive to H2 dissociation. Moreover, as revealed by density functional theory calculations and poisoning experiments, the P site in Ir1─P1/NPG is found able to bind nitrostyrene, while the neighboring Ir site provides H to reduce the nitro group in chemoselective hydrogenation of nitrostyrene. This work offers a successful example of establishing atomic catalytic pair for driving important chemical reactions, paving the way for the development of more advanced catalysts to further improve the catalytic performance.
Lepr‐Expressing PDLSCs Contribute to Periodontal Homeostasis and Respond to Mechanical Force by Piezo1
Authors: Zhang Danting , Lin Weimin , Jiang Shuang , Deng Peng , Liu Linfeng , Wang Qian , Sheng Rui , Shu Hui Sophie , Wang Lijun , Zou Weiguo , Zhou Bo O. , Jing Junjun , Ye Ling , Yu Bo , Zhang Shiwen , Yuan Quan 
Published: August 2023

AbstractPeriodontium supports teeth in a mechanically stimulated tissue environment, where heterogenous stem/progenitor populations contribute to periodontal homeostasis. In this study, Leptin receptor+ (Lepr+) cells are identified as a distinct periodontal ligament stem cell (PDLSC) population by single‐cell RNA sequencing and lineage tracing. These Lepr+ PDLSCs are located in the peri‐vascular niche, possessing multilineage potential and contributing to tissue repair in response to injury. Ablation of Lepr+ PDLSCs disrupts periodontal homeostasis. Hyper‐loading and unloading of occlusal forces modulate Lepr+ PDLSCs activation. Piezo1 is demonstrated that mediates the mechanosensing of Lepr+ PDLSCs by conditional Piezo1‐deficient mice. Meanwhile, Yoda1, a selective activator of Piezo1, significantly accelerates periodontal tissue growth via the induction of Lepr+ cells. In summary, Lepr marks a unique multipotent PDLSC population in vivo, to contribute toward periodontal homeostasis via Piezo1‐mediated mechanosensing.
Quasi‐Copper‐Mers Enable High‐Performance Catalysis for CO2 Reduction
Authors: Yang Jing , Liu Ximeng , Li Zhao , Xi Shibo , Sun Jianguo , Yuan Hao , Liu Weihao , Wang Tuo , Gao Yulin , Wang Haimei , Wang Junjie , Chen Jun Song , Wu Rui , Zhang Yong‐Wei , Wang John 
Published: August 2023

AbstractAs the atmospheric carbon dioxide (CO2) level keeps hitting the new record, humanity is facing an ever‐daunting challenge to efficiently mitigate CO2 from the atmosphere. Though electrochemical CO2 reduction presents a promising pathway to convert CO2 to valuable fuels and chemicals, the general lack of suitable electrocatalysts with high activity and selectivity severely constrains this approach. Herein, a novel class of electrocatalysts is investigated, the quasi‐copper‐mers, in which the CuN4 rather than Cu atom itself serve as the basic building block. The respective quasi‐copper‐monomers, ‐dimers, and ‐trimers hosted in a graphene‐like substrate are first synthesized and then performed both experimental characterization and density functional theory (DFT) calculations to examine their atomic structures, evaluate their electrocatalytical performance and understand their underlying mechanisms. The experimental results show that the quasi‐copper‐trimers not only outperform the quasi‐copper‐dimer and quasi‐copper‐monomer when catalyzing CO2 to CO, it also shows a superior selectivity against the competing hydrogen evolution reaction (HER). The DFT calculations not only support the experimental observations, but also reveal the volcano curve and the physical origin for the qausi‐copper‐trimer superiority. The present work thus presents a new strategy in the design of high‐performance electrocatalysts with high activity and selectivity.
Enhancing the Catalytic Kinetics and Stability of Ru Sites for Acidic Water Oxidation by Forming Brønsted Acid Sites in Tungsten Oxide Matrix
Authors: Wang Xuefeng , Jang Haeseong , Liu Shangguo , Li Zijian , Zhao Xuhao , Chen Yunfei , Kim Min Gyu , Qin Qing , Liu Xien 
Published: August 2023

AbstractThe oxygen evolution reaction (OER) suffers from sluggish kinetics even on the benchmark RuO2 catalyst, due to the complex four sequential proton‐coupled electron transfer steps. Severe electrochemical oxidation and dissolution issues also make RuO2 fail as an alternative to highly expensive iridium‐based OER catalysts applied in proton exchange membrane water electrolysis. Herein, an acid‐stable W18O49‐δ matrix‐confined Ru solid solution oxide is developed with considerably reduced Ru loadings beyond commercial RuO2, to enhance the acidic OER kinetics and extend the long‐term durability simultaneously by incorporating Brønsted acid sites. The representative Ru0.6W17.4O49‐δ with 3D urchin‐like morphology achieves an excellent catalytic stability with ultra‐slow degradation rate and a high mass activity of 27 110 A g−1Ru @ 1.53 V versus RHE in 0.1 m HClO4 electrolyte, which is ≈10.8 times higher than that of commercial RuO2. The enhanced electron transfer from W to Ru during the OER process prevents the over‐oxidation of surface Ru sites extending the long‐term stability, while the incorporated Ru‐Obri‐W Brønsted acid sites accelerate the deprotonation step by promoting the mobility of proton from the oxo‐intermediate to the neighboring Obri sites, thus boosting the acidic OER kinetics.
A Noonan‐like pediatric patient with a de novo CBL pathogenic variant and an RNF213 polymorphism p.R4810K presenting with cardiopulmonary arrest due to left main coronary artery ostial atresia
Authors: Chida‐Nagai Ayako , Tonoki Hidefumi , Makita Naomasa , Ishiyama Hiroyuki , Ihara Masafumi , Maruo Yuji , Tsujioka Takao , Sasaki Daisuke , Izumi Gaku , Yamazawa Hirokuni , Kato Nobuyasu , Ito Masaki , Fujimura Miki , Sasaki Osamu , Takeda Atsuhito 
Published: August 2023

AbstractLeft main coronary artery ostial atresia (LMCAOA) is an extremely rare condition. Here, we report the case of a 14‐year‐old boy with Noonan syndrome‐like disorder in whom LMCAOA was detected following cardiopulmonary arrest. The patient had been diagnosed with Noonan syndrome‐like disorder with a pathogenic splice site variant of CBL c.1228‐2 A > G. He suddenly collapsed when he was running. After administering two electric shocks using an automated external defibrillator, the patient's heartbeat resumed. Cardiac catheterization confirmed the diagnosis of LMCAOA. Left main coronary artery angioplasty was performed. The patient was discharged without neurological sequelae. Brain magnetic resonance imaging revealed asymptomatic Moyamoya disease. In addition, RNF213 c.14429 G > A p.R4810K was identified. There are no reports on congenital coronary malformations of compound variations of RNF213 and CBL. In contrast, the RNF213 p.R4810K polymorphism has been established as a risk factor for angina pectoris and myocardial infarction in adults, and several congenital coronary malformations due to genetic abnormalities within the RAS/MAPK signaling pathway have been reported. This report aims to highlight the risk of sudden death in patients with RASopathy and RNF213 p.R4810K polymorphism and emphasize the significance of actively searching for coronary artery morphological abnormalities in these patients.
Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?
Authors: Hagedorn Robert , Tullis Benton , Nguyen Cassidy , Stockard Ryan , Mace Jess C , Ramakrishnan Vijay R , Beswick Daniel M , Soler Zachary M , Smith Timothy L , Alt Jeremiah A , Gill Amarbir S 
Published: August 2023

AbstractBackgroundPoor air quality increases the risk of developing chronic rhinosinusitis (CRS) and other airway diseases. However, there are limited data on air pollutants and CRS‐specific disease severity. We assessed the impact of air pollutants on sinonasal‐specific and general quality‐of‐life (QOL) measures in a multi‐institutional cohort of patients with CRS.MethodsParticipants with CRS were prospectively enrolled in a cross‐sectional study and self‐selected continued appropriate medical therapy or endoscopic sinus surgery (ESS). The 22‐item SinoNasal Outcome Test (SNOT‐22) and Medical Outcomes Study Questionnaire Short‐Form 6‐D (SF‐6D) health utility value scores were recorded. Patient exposure to air pollutants was determined using residence zip codes. Unadjusted group differences were compared, and correlation coefficients were evaluated to identify the magnitude of bivariate association.ResultsA total of 486 patients were enrolled and followed for a mean of 6.9 (standard deviation [SD] ± 2.3) months. Pollutant exposure did not significantly correlate with baseline SNOT‐22 or SF‐6D scores. Revision ESS was associated with higher median fine particulate matter (PM2.5; Δ = 0.12, [95% confidence interval {CI}: 0.003, 0.234]; p = 0.006) compared with primary surgery. PM2.5, PM10, and nitrogen dioxide concentrations (μg/m3) did not correlate with change in total SNOT‐22 or SF‐6D scores after treatment. Nevertheless, sulfur dioxide (SNOT‐22: ρ = –0.121 [95% CI: –0.210, –0.030]; p = 0.007; SF‐6D: ρ = 0.095 [95% CI: 0.002, 0.186]; p = 0.04) and carbon monoxide (SNOT‐22: ρ = ‐0.141 [95% CI: –0.230, 0.050]; p = 0.002) exposure did correlate with these outcome measures.ConclusionAir pollutants may contribute, at least in part, to disease severity in CRS; future investigation is needed to further elucidate the nature of this relationship.
Synthetic Heparanase Inhibitors Can Prevent Herpes Simplex Viral Spread
Authors: Chopra Pradeep , Yadavalli Tejabhiram , Palmieri Francesco , Jongkees Seino A. K. , Unione Luca , Shukla Deepak , Boons Geert‐Jan 
Published: August 2023

AbstractHerpes simplex virus (HSV‐1) employs heparan sulfate (HS) as receptor for cell attachment and entry. During late‐stage infection, the virus induces the upregulation of human heparanase (Hpse) to remove cell surface HS allowing viral spread. We hypothesized that inhibition of Hpse will prevent viral release thereby representing a new therapeutic strategy for HSV‐1. A range of HS‐oligosaccharides was prepared to examine the importance of chain length and 2‐O‐sulfation of iduronic moieties for Hpse inhibition. It was found that hexa‐ and octasaccharides potently inhibited the enzyme and that 2‐O‐sulfation of iduronic acid is tolerated. Computational studies provided a rationale for the observed structure–activity relationship. Treatment of human corneal epithelial cells (HCEs) infected with HSV‐1 with the hexa‐ and octasaccharide blocked viral induced shedding of HS which significantly reduced spread of virions. The compounds also inhibited migration and proliferation of immortalized HCEs thereby providing additional therapeutic properties.
Photoactivatable Carbo‐ and Silicon‐Rhodamines and Their Application in MINFLUX Nanoscopy
Authors: Aktalay Ayse , Khan Taukeer A. , Bossi Mariano L. , Belov Vladimir N. , Hell Stefan W. 
Published: August 2023

AbstractNew photoactivatable fluorescent dyes (rhodamine, carbo‐ and silicon‐rhodamines [SiR]) with emission ranging from green to far red have been prepared, and their photophysical properties studied. The photocleavable 2‐nitrobenzyloxycarbonyl unit with an alpha‐carboxyl group as a branching point and additional functionality was attached to a polycyclic and lipophilic fluorescent dye. The photoactivatable probes having the HaloTagTM amine (O2) ligand bound with a dye core were obtained and applied for live‐cell staining in stable cell lines incorporating Vimentin (VIM) or Nuclear Pore Complex Protein NUP96 fused with the HaloTag. The probes were applied in 2D (VIM, NUP96) and 3D (VIM) MINFLUX nanoscopy, as well as in superresolution fluorescence microscopy with single fluorophore activation (VIM, live‐cell labeling). Images of VIM and NUPs labeled with different dyes were acquired and their apparent dimensions and shapes assessed on a lower single‐digit nanometer scale. Applicability and performance of the photoactivatable dye derivatives were evaluated in terms of photoactivation rate, labeling and detection efficiency, number of detected photons per molecule and other parameters related to MINFLUX nanoscopy.
Preparation of bimetallic metal–organic frameworks for adsorbing doxycycline hydrochloride from wastewater
Authors: Wei Fuhua , Nie Meng , Ren Qinhui , Yu Xiang , Li Hua , Chen Hongliang , He Mengting , Liang Zhao , Wang Siyuan , Han Dongxue 
Published: August 2023

This work studies the use of Cu/Co‐MOFs for the removal of doxycycline hydrochloride (DOC) in wastewater. Cu/Co‐MOFs were prepared using a solvothermal method and characterized by XRD, SEM, and TG. According to the experimental results, the maximum DOC adsorption capacity of Cu/Co‐MOFs within 5 h was 268.5 mg/g. The pseudo‐second‐order (PSO) kinetic model shows that theR2are all greater than 0.99, which proves that the theory DOC adsorption by Cu/Co‐MOFs is consistent with practice. According to the Freundlich isotherm model, the adsorption of DOC by Cu/Co‐MOFs is a multilayer adsorption. Thus, the results show that Cu/Co‐MOFs have practical application value in removing DOC.