bluuebunny/crossref_metadata_2025_split huggingface dataset:
ECMO as a bridge to cardiac surgery: stabilizing unstable patients for a definitive procedure
Authors: Raman Jai , Saxena Pankaj , Dobrilovic Nikola 
Published: May 2023

Abstract
Introduction
Extracorporeal membrane oxygenation (ECMO) in adults has been used in post-cardiotomy patients who decline hemodynamically. Cardiogenic shock in patients with potential surgically correctable cardiac conditions are at significantly higher risk for post-operative morbidity and mortality. We present experience with a pre-emptive approach of ECMO institution pre-operatively to stabilize patients with cardiogenic shock.

Materials and methods
This study expands on a pilot study with a group of twenty patients who were supported with ECMO pre-operatively in different institutions over a period between 2011 and 2021. The patients presented with cardiogenic shock. Peripheral veno-arterial (VA) ECMO support was used in all the patients. Cardiac surgery was performed via median sternotomy utilizing the in situ ECMO cannulae to institute cardiopulmonary bypass (CPB).

Results
Seventeen patients were weaned off ECMO support following a mean duration of support of 156 h. Fifteen patients survived to discharge. The 30-day mortality and in-hospital mortality were 25% (expected 67% by European System for Cardiac Operative Risk Evaluation (EuroSCORE) II). The causes of mortality included persistent bleeding in 2 patients due to liver dysfunction, and one with low platelet counts. The other two had multi-organ failure.

Conclusions
Variable period of pre-operative ECMO support provides hemodynamic stability and may prevent or reverse the multi-organ dysfunction if instituted on time in patients presenting with cardiogenic shock. This strategy allows cardiac surgery to be performed with acceptable risk.
High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing
Authors: Gao Ruikang , Zhou Peng , Li YiQing , Li Qin 
Published: May 2023

AbstractIt is widely acknowledged that diabetes leads to slow wound healing and ulceration, and severe serious diabetic foot ulceration may result in amputation. In recent years, much emphasis has been placed on exploring diabetic wound healing to protect patients from adverse events. We recently found interleukin-7 (IL-7), a growth factor for B-cells and T-cells, and its receptor was significantly upregulated in high glucose-induced fibroblasts and skin of diabetic mice. Moreover, IL-7 stimulated fibroblasts secreted ANGPTL4, which inhibited angiogenesis of endothelial cells resulting in delayed wound healing. In our previous study, fibroblasts, endothelial cells and keratinocytes were exposed to normal glucose (5.5 mM) or high glucose (30 mM) medium for 24 h, and RNA sequencing showed that IL-7 and IL-7R were significantly upregulated in fibroblasts. To remove the effect of high glucose and explore the influence of IL-7, exogenous rMuIL-7 used to treat normal mice led to delayed wound healing by inhibiting angiogenesis. Vitro experiments revealed that IL-7-induced fibroblasts inhibited endothelial cell proliferation, migration and angiogenesis. Further experiments showed that fibroblast angiopoietin-like-4 (ANGPTL4) secretion exhibited the inhibitory effect which was blocked by culture with the corresponding neutralizing antibody. Overall, our study revealed signaling pathways associated with diabetic wound healing and provided the foothold for further studies on delayed wound healing in this patient population.
Graphical abstract
Mechanism that high glucose activates IL-7-IL-7R-ANGPTL4 signal pathway in delayed wound healing. High glucose upregulates IL-7 and IL-7R in dermal fibroblasts. IL-7 stimulates dermal fibroblasts secreting Angptl4 which inhibits proliferation, migration and angiogenesis of endothelial cells in a paracrine way.
Multilateral Development Banks as Agents of Connectivity: the Asian Development Bank (ADB) and the Asian Infrastructure Investment Bank (AIIB)
Authors: Creutz Katja 
Published: May 2023

Abstract
The article explores connectivity from the prism of multilateral development banks. It recognises that theorising on connectivity is increasing, but as connectivity agency is less addressed, it aims to contribute to discussions on who the agents of connectivity are and how they contribute thereto. By analysing the Asian Development Bank (ADB) and the Asian Infrastructure Bank (AIIB) respectively, the article sets forth a three-dimensional agency: strategic, developmental and financial. This is in line with the multi-layered nature of the banks, which reflects the broader member states and key state interests. Next to their role as banks, they contribute to the understanding of development, in addition to which they represent key shareholder interests. The banks are both to be seen as nodes of connectivity and as active agents in realising connectivity for others.
Higher moment connectedness of cryptocurrencies: a time-frequency approach
Authors: Nyakurukwa Kingstone , Seetharam Yudhvir 
Published: May 2023

AbstractThe purpose of the study is to examine higher moment connectedness among 12 cryptocurrencies using data sampled at the 1-minute high-frequency interval. We use methods that demonstrate the heterogeneity of agents from their distinct investing horizons. This includes wavelet multiple cross-correlations, CEEMDAN-based Diebold-Yilmaz (DY) connectedness index and the Barunik-Krehlik (BK) frequency connectedness index. First, our results show that higher moment multiple correlations among the sampled cryptocurrencies are higher at all time scales and the relationship strengthens at lower frequencies. Second, the wavelet cross-correlations show different cryptocurrencies with the potential to lead and lag in the transmission of higher moment shocks to the whole system at different frequencies. Again, the multiple wavelet cross-correlations increase with increasing time scales. The results from the CEEMDAN-based DY connectedness index as well as the BK framework also reveal cyclical connectedness and differences in connectedness across different frequencies. The results show more connectedness of higher moments than the connectedness empirically reported for returns and volatility. Cryptocurrency connectedness has mostly been examined using the first two moments. We extend this line of literature by examining the third and fourth moments, which might be more useful for risk management purposes.
Real-world treatment patterns and outcomes of abemaciclib for the treatment of HR + , HER2- metastatic breast cancer patients in Japan
Authors: Nozawa K. , Terada M. , Onishi M. , Ozaki Y. , Takano T. , Fakhouri W. , Novick D. , Haro J. M. , Faris L. H. , Kawaguchi T. , Tanizawa Y. , Tsurutani Junji 
Published: May 2023

Abstract
Introduction
This study described, in routine clinical practice in Japan, the patient characteristics, treatment patterns, and outcomes of female patients with HR + /HER2- metastatic breast cancer (MBC) who started abemaciclib treatment.

Methods
Clinical charts were reviewed for patients starting abemaciclib in 12/2018–08/2021 with a minimum of 3 months follow-up data post-abemaciclib initiation regardless of abemaciclib discontinuation. Patient characteristics, treatment patterns, and tumor response were descriptively summarized. Kaplan–Meier curves estimated progression-free survival (PFS).

Results
200 patients from 14 institutions were included. At abemaciclib initiation, median age was 59 years, and the Eastern Cooperative Oncology Group performance status score was 0/1/2 for 102/68/5 patients (58.3/38.9/2.9%), respectively. Most had an abemaciclib starting dose of 150 mg (92.5%). The percentage of patients receiving abemaciclib as 1st, 2nd, or 3rd line treatment was 31.5%, 25.8%, and 25.2%, respectively. The most frequent endocrine therapy drugs used with abemaciclib were fulvestrant (59%) and aromatase inhibitors (40%). Evaluation of tumor response was available for 171 patients, 30.4% of whom had complete/partial response. Median PFS was 13.0 months (95% CI 10.1–15.8 months).

Conclusions
In a routine clinical practice setting in Japan, patients with HR + , HER2- MBC appear to benefit from abemaciclib treatment in terms of treatment response and median PFS, with the results broadly reflecting the evidence demonstrated in clinical trials.
IT Professionals in the Gig Economy
Authors: Gussek Lisa , Wiesche Manuel 
Published: May 2023

AbstractWhen IT work is performed through digital labor markets, IT professionals have a high degree of personal responsibility for their careers and must use appropriate strategies to be successful. This paper investigates the success of IT freelancers on digital labor platforms. Drawing on signaling theory, a dataset of 7166 IT freelancers is used to examine how activating, pointing, and supporting signals lead to success. Analysis was carried out using negative binomial regression. The results indicate that the three signaling types positively influence the objective career success of IT freelancers. This paper contributes to the literature by testing signaling theory in the new context of digital labor platforms, investigating IT specifics, and proposing support as a new type of signal for IT professionals on digital labor platforms. In practice, the results provide guidelines for IT freelancers to improve their success within their careers.
Underexplored reciprocity between genome-wide methylation status and long non-coding RNA expression reflected in breast cancer research: potential impacts for the disease management in the framework of 3P medicine
Authors: Kapinova Andrea , Mazurakova Alena , Halasova Erika , Dankova Zuzana , Büsselberg Dietrich , Costigliola Vincenzo , Golubnitschaja Olga , Kubatka Peter 
Published: May 2023

AbstractBreast cancer (BC) is the most common female malignancy reaching a pandemic scale worldwide. A comprehensive interplay between genetic alterations and shifted epigenetic regions synergistically leads to disease development and progression into metastatic BC. DNA and histones methylations, as the most studied epigenetic modifications, represent frequent and early events in the process of carcinogenesis. To this end, long non-coding RNAs (lncRNAs) are recognized as potent epigenetic modulators in pathomechanisms of BC by contributing to the regulation of DNA, RNA, and histones’ methylation. In turn, the methylation status of DNA, RNA, and histones can affect the level of lncRNAs expression demonstrating the reciprocity of mechanisms involved. Furthermore, lncRNAs might undergo methylation in response to actual medical conditions such as tumor development and treated malignancies. The reciprocity between genome-wide methylation status and long non-coding RNA expression levels in BC remains largely unexplored. Since the bio/medical research in the area is, per evidence, strongly fragmented, the relevance of this reciprocity for BC development and progression has not yet been systematically analyzed. Contextually, the article aims at:consolidating the accumulated knowledge on both—the genome-wide methylation status and corresponding lncRNA expression patterns in BC andhighlighting the potential benefits of this consolidated multi-professional approach for advanced BC management.Based on a big data analysis and machine learning for individualized data interpretation, the proposed approach demonstrates a great potential to promote predictive diagnostics and targeted prevention in the cost-effective primary healthcare (sub-optimal health conditions and protection against the health-to-disease transition) as well as advanced treatment algorithms tailored to the individualized patient profiles in secondary BC care (effective protection against metastatic disease). Clinically relevant examples are provided, including mitochondrial health control and epigenetic regulatory mechanisms involved.
Multi-faceted CRISPR/Cas technological innovation aspects in the framework of 3P medicine
Authors: Lučanský Vincent , Holubeková Veronika , Kolková Zuzana , Halašová Erika , Samec Marek , Golubnitschaja Olga 
Published: May 2023

Abstract
Since 2009, the European Association for Predictive, Preventive and Personalised Medicine (EPMA, Brussels) promotes the paradigm change from reactive approach to predictive, preventive, and personalized medicine (PPPM/3PM) to protect individuals in sub-optimal health conditions from the health-to-disease transition, to increase life-quality of the affected patient cohorts improving, therefore, ethical standards and cost-efficacy of healthcare to great benefits of the society at large. The gene-editing technology utilizing CRISPR/Cas gene-editing approach has demonstrated its enormous value as a powerful tool in a broad spectrum of bio/medical research areas. Further, CRISPR/Cas gene-editing system is considered applicable to primary and secondary healthcare, in order to prevent disease spread and to treat clinically manifested disorders, involving diagnostics of SARS-Cov-2 infection and experimental treatment of COVID-19. Although the principle of the proposed gene editing is simple and elegant, there are a lot of technological challenges and ethical considerations to be solved prior to its broadly scaled clinical implementation. This article highlights technological innovation beyond the state of the art, exemplifies current achievements, discusses unsolved technological and ethical problems, and provides clinically relevant outlook in the framework of 3PM.
Evaluation of SEBS and SEBAL algorithms for estimating wheat evapotranspiration (case study: central areas of Khuzestan province)
Authors: Zoratipour Elahe , Mohammadi Amir Soltani , Zoratipour Amin 
Published: May 2023

AbstractThis study aimed to accurately estimate daily wheat evapotranspiration using two remote sensing algorithms, Surface Energy Balance System (SEBS) and Surface Energy Balance Algorithm for Land (SEBAL), in central Khuzestan province during 2019–2020. The results of two algorithms were compared with lysimeter (as a direct method), FAO-Penman–Monteith (FAO-PM), two temperature-based methods (Hargreaves-Samani and Blaney-Criddle), two radiation-based methods (Priestley–Taylor and Doorenbos–Pruitt), and two mass transfer-based methods (Mahringer and World Meteorology Organization) (as indirect methods). Coefficient of Determination (R2), Root-Mean-Square Error (RMSE), Percentage of Bias (PBIAS), Mean Bias Error, Mean Absolute Percentage Error, and Nash–Sutcliffe indicators used for comparing the results. According to the results, both SEBAL and SEBS algorithms showed the highest compatibility with lysimeter data (R2 = 0.92 and 0.96, RMSE = 2.15 and 1.53 mm/day, respectively). Comparing both algorithms with the FAO-PM method, resulted in RMSE and R2 of 2.42 mm/day and 0.87 for SEBS and 3.14 mm/day and 0.79 for SEBAL. The Hargreaves-Samani method (R2 = 0.72, RMSE = 16.4 mm/day) and (R2 = 0.8, RMSE = 10.4 mm/day) among temperature-based methods, Doorenbos–Pruitt (R2 = 0.71, RMSE = 3.33 mm/day) and (R2 = 0.79, RMSE = 2.63 mm/day) among radiation-based methods, and the Mahringer method (R2 = 0.6, RMSE = 6.8 mm/day mm/day) and (R2 = 0.68, RMSE = 5.51 mm/day) among mass transfer-based methods yielded better estimations than SEBAL and SEBS algorithms, respectively. Owing to the high accuracy of SEBAL and SEBS algorithms, in estimating the amount of evapotranspiration in the study area and close to the actual values in the field, using energy balance algorithms is recommended in Khuzestan province.
Advanced Organotypic In Vitro Model Systems for Host–Microbial Coculture
Authors: Kim Raehyun 
Published: May 2023

AbstractIn vitro model systems have been advanced to recapitulate important physiological features of the target organ in vivo more closely than the conventional cell line cultures on a petri dish. The advanced organotypic model systems can be used as a complementary or alternative tool for various testing and screening. Numerous data from germ-free animal studies and genome sequencings of clinical samples indicate that human microbiota is an essential part of the human body, but current in vitro model systems rarely include them, which can be one of the reasons for the discrepancy in the tissue phenotypes and outcome of therapeutic intervention between in vivo and in vitro tissues. A coculture model system with appropriate microbes and host cells may have great potential to bridge the gap between the in vitro model and the in vivo counterpart. However, successfully integrating two species in one system introduces new variables to consider and poses new challenges to overcome. This review aims to provide perspectives on the important factors that should be considered for developing organotypic bacterial coculture models. Recent advances in various organotypic bacterial coculture models are highlighted. Finally, challenges and opportunities in developing organotypic microbial coculture models are also discussed.
Digital Civics and Algorithmic Citizenship in a Global Scenario
Authors: Tomasello Federico 
Published: May 2023

AbstractHow should the notion of civics be rethought in the digital age and within the infosphere? The commentary addresses this question by focusing on two main issues. The first part delves into the effects of the dynamics of “surveillance capitalism” and datafication processes on the possible developments of the idea of civics in the digital sphere. It stresses the need to set the issue of users’ data rights at the center of digital civic initiatives. The second part explores the notions of political community and membership that should underpin the idea of digital civics. It argues that the diverse range of values and virtues which shape civics on a global scale should be taken into consideration to define the spatial scope—or political geography—of the community to which digital civic initiatives are addressed.
Iperparatiroidismo nel contesto della MEN2A: dalla genetica alla gestione clinica
Authors: Gambale Carla , Matrone Antonio , Prete Alessandro , Romei Cristina , Elisei Rossella 
Published: May 2023

SommarioL’iperparatiroidismo primitivo (IPP), condizione caratterizzata da aumentata secrezione di paratormone e conseguente aumento dei valori di calcemia, può presentarsi sia in forma sporadica che familiare. Tra le forme familiari, l’IPP rappresenta una manifestazione caratteristica delle sindromi da neoplasie endocrine multiple (MEN) tipo 1, 2A e 4. Le caratteristiche cliniche dell’IPP differiscono tra diverse forme di MEN e rispetto alla forma sporadica. L’incidenza di IPP nel contesto della MEN2A varia in base al codone di RET coinvolto dalla mutazione. Nella maggioranza dei casi l’IPP è diagnosticato nel corso del follow-up dei pazienti con MEN 2A, di solito successivamente alla comparsa del carcinoma midollare della tiroide (CMT), presentandosi clinicamente in forma lieve o del tutto asintomatica. Il trattamento di scelta è l’asportazione chirurgica delle paratiroidi iperfunzionanti, accompagnata dall’esplorazione cervicale bilaterale in considerazione del potenziale coinvolgimento multighiandolare.
Popular solunar tables fail to predict fishing success in North American recreational freshwater trout fisheries
Authors: Quigley Calvin N. , Murcia Josue D. Gonzalez , Kauwe John S. K. 
Published: May 2023

AbstractThe solunar theory proposes that the position of the sun and moon can be used to predict activity rates in fish and game species. Several free and premium services use this theory to provide tables predicting optimal dates and times for fishing and hunting success. The efficacy of these services was tested by comparing catch per unit effort (CPUE) in a recreational freshwater trout fishery with daily solunar values and coincidence of fishing trips with peak solunar times. CPUE was also compared to environmental variables including lunar phase, lunar illumination, and wind speed. Values predicted by each of the solunar services were strongly correlated to each other and to lunar phase, however, no significant relationship was found between CPUE and any of the solunar values tested, lunar phase, or lunar illumination. Ambient air temperature showed a positive relationship with CPUE, and was a more effective predictor of fishing success than any of the solunar tables tested.
Biomass and enzymatic activities of marine bacteria in the presence of multiple metals
Authors: Bitencourt J. A. P. , Chequer L. P. T. , Waite C. C. , Oliveira G. , Oliveira A. M. S. , Pereira D. C. , Crapez M. A. C. 
Published: May 2023

AbstractMarine environments are a repository for metals, and humans have enhanced this phenomenon over the years. Heavy metals are notoriously toxic due to their ability to biomagnify in the food chain and interact with cellular components. Nevertheless, some bacteria have physiological mechanisms that enable them to survive in impacted environments. This characteristic makes them important as biotechnological tools for environmental remediation. Thus, we isolated a bacterial consortium in Guanabara Bay (Brazil), a place with a long metal pollution history. To test the growth efficiency of this consortium in Cu–Zn-Pb-Ni–Cd medium, we measured the activity of key enzymes of microbial activity (esterases and dehydrogenase) under acidic (4.0) and neutral pH conditions, as well as the number of living cells, biopolymer production, and changes in microbial composition during metal exposure. Additionally, we calculated the predicted physiology based on microbial taxonomy. During the assay, a slight modification in bacterial composition was observed, with low abundance changes and little production of carbohydrates. Oceanobacilluschironomi, Halolactibacillus miurensis, and Alkaliphilus oremlandii were predominant in pH 7, despite O. chironomi and Tissierella creatinophila in pH 4, and T. creatinophila in Cu–Zn-Pb-Ni–Cd treatment. The metabolism represented by esterases and dehydrogenase enzymes suggested bacterial investment in esterases to capture nutrients and meet the energy demand in an environment with metal stress. Their metabolism potentially shifted to chemoheterotrophy and recycling nitrogenous compounds. Moreover, concomitantly, bacteria produced more lipids and proteins, suggesting extracellular polymeric substance production and growth in a metal-stressed environment. The isolated consortium showed promise for bioremediation of multimetal contamination and could be a valuable tool in future bioremediation programs.
Innovation in the 21st century: following the footsteps of Katalin Karikó
Authors: Deák Csaba , Pardi Norbert , Miklósi Ádám 
Published: May 2023

AbstractInnovation is a critical component of human society, setting us apart from other animals. We possess a unique capacity to design and produce new things through cultivating a culture that values and encourages innovation. One remarkable instance of innovation in the field of biology and medicine is the mRNA vaccine platform developed by Katalin Karikó and her colleagues. In this article, we delve into the evolution of mRNA-based therapy, beginning with animal models and concluding with the first clinical trials. The history of mRNA research began with the identification of its role in protein synthesis, leading to the development of mRNA vaccine technology. Karikó's pivotal innovation was discovering the need to integrate modified nucleosides into the mRNA, decreasing its recognition by the immune system. Her story offers valuable lessons, including the importance of market demand as a booster effect, the role of emerging technologies, the significance of universities and academic institutions in fostering innovation, the role of perseverance and faith, and the role of chance.