bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fenomenología sobre la neuroeducación en el subnivel de preparatoria: concepciones del profesorado
Authors: Loor-Llanos Lilian , Torrealba Peña Mairelys 
Published: June 2023

El objetivo de este estudio fue identificar las concepciones sobre la aplicabilidad de la neuroeducación en las prácticas pedagógicas de los docentes del subnivel preparatorio de educación general básica adscritos a un centro educativo fiscal de Ecuador. Su importancia radica en la potencialidad de la neuroeducación en redireccionar el trabajo pedagógico en provecho de una formación humanista. La investigación se abordó bajo un paradigma interpretativo, manteniendo un enfoque cualitativo y el método fenomenológico. Se utilizó la entrevista semiestructurada, basada en un guion. Se aplicó el proceso de categorización a los testimonios de las doce docentes informantes clave, de donde emergieron las siguientes categorías: “Neuroeducación como paradigma nuevo de enseñanza”, “Personalización de la educación” y “Estrategias didácticas centradas en el estudiante”, esta última con las subcategorías: “Impulso de la gestión emocional” y “Fomento de actividades artísticas”. La triangulación teórica (Martínez, 2007) evidenció que la neuroeducación, desde la óptica de los entrevistados, alude a metodologías didácticas que estimulan la participación creativa, espontánea y amena de los estudiantes, apoyándose en la creación de experiencias educativas basadas en la inteligencia emocional, el juego, el arte y la reducción de cualquier estado emocional que interfiera con el desarrollo holístico de los estudiantes.
Experiencias de aprendizaje y expectativas académicas en universitarios mexicanos durante la COVID-19
Authors: Gaeta Laura , Rodríguez Guardado María del Socorro , Gaeta Martha Leticia , Malpica Olga 
Published: June 2023

En este estudio se analizaron las experiencias de aprendizaje y las expectativas académicas de estudiantes universitarios mexicanos durante la educación remota de emergencia, aplicada en el segundo año de distanciamiento social por la COVID-19. Se realizó un estudio cualitativo basado en entrevistas semiestructuradas a 21 estudiantes, 10 mujeres y 11 hombres, de licenciatura (57.1 %) y de posgrado (41.9 %) de tres universidades. Los resultados indican que el aprendizaje en línea fue una experiencia agotadora y desafiante para el estudiantado, que implicó procesos de gestión personal, del ambiente y de los recursos. Las y los estudiantes valoraron los ajustes instruccionales y de evaluación del profesorado, pero destacaron la falta de socialización como un aspecto sustancial en sus experiencias de aprendizaje. Además, manifestaron optimismo para continuar sus estudios a la luz de sus expectativas. Sin embargo, consideraron que su preparación académica se vio mermada, lo cual puede tener implicaciones para su futuro desempeño académico y profesional.
Factors Hindering Elimination of Mother to Child Transmission of HIV Service Uptake among HIV Positive Women at Comboni Hospital Kyamuhunga Bushenyi District
Authors: Viola Nankya , Kimono Esther , Nuruh Ndagire , Obeagu Emmanuel Ifeanyi 
Published: June 2023

In the absence of preventive measures HIV infected mothers transmit the infection to their babies during pregnancy delivery and breastfeeding. However, improving eMTCT service uptake and continuum of care still remains a significant impediment in the western region of Uganda. The study was to explore factors hindering eMTCT service uptake among HIV positive women at Comboni Hospital Kyamuhunga. A descriptive cross-section design was used and majorly simple random sampling was employed with a number of 36 respondents and interviewed response were analysed using SPSS version to determine the association between the independent and dependent variable.
The findings of the study revealed that there are a range of factors that hinder HIV positive women on eMTCT service uptake, disclosure of HIV status with 77.7%, lack of partner and family support with 75%, dependence on partners with 80.6%, long waiting times at facility and no linkage to support groups with 33.3%and 47.2% respectively. In conclusion Strengthening community awareness on the importance of eMTCT service uptake, improving on time management by health workers, engaging male involvement in eMTCT care, improve youth friendly services, empowering women, putting emphasis on disclosure of status and supporting young mothers is so crucial.
Keywords: elimination, mother to child transmission, HIV service uptake, HIV positive women
Histopathological and Biochemical Effect of Vitamin C and D on Phosphine-Induced Hepatotoxicity in Wistar Rats
Authors: Akinpelu Moronkeji , Gamade Solomon Matthias , Akinbo Frederick , Adeniyi Temidayo Daniel , Elizebeth Adebowale Funmilola , Obeagu Emmanuel Ifeanyi 
Published: June 2023

Background: Aluminum phosphide is becoming a very common agent for self-poisoning. The lack of specific antidote for phosphide poisoning has aroused the current interest of research.
Objectives: This study aimed to investigate the possible protective effect of Vitamin C and D in phosphine-induced hepatotoxicity in Wistar rats.
Methods: In this experimental study, 20 Wistar rats were randomly divided into five groups ( n = 12). Group I was apparently normal Control Group. Groups II-V were induced with 2.5 mg/kg ALP. Groups II was without further treatment while Groups III-IV received vitamin C at 100mg/kg/bw and vitamin D at 10mg/kg/bw. Group V was co-administered with vitamin C at 100mg/kg/bw and vitamin at 10mg/kg/bw. The treatments lasted for 28 days.
Results: The results showed that Vitamin C and D (P<0.05) increased antioxidant capacity. Combined active constituents of the Vitamin C and Vitamin D raised the GPX antioxidant activities when compared to the phosphine poisoned group treated individually with Vitamin C and D. The combined activities of Vitamin C and Vitamin D showed the highest antioxidant effect as compared with the control
Conclusion: The combined activities of Vitamin C and D supplementation improved the antioxidant defense system and histology of the liver in phosphine poisoning.
Keywords: Metal phosphide, Carotene, Liver cell damage, Poison
Doxorubicin layer-by-layer nanoparticles for controlled delivery and effective treatment of pancreatic cancer
Authors: Rawal Vinni , Joshi Hricha , Gangwar Poonam , Dixit Anjali , Tiwari Neha , Nigam Parul , Kumar Pramod 
Published: June 2023

Introduction: Layer-by-layer (LbL) nanoparticles consist of a versatile drug delivery technique, for targeted and controlled delivery. The Doxorubicin (DRC) is being widely used for treatment of pancreatic cancer (PCR). The present study was performed to develop and evaluation LbL nanoparticles (NP’s) of DRC to provide controlled and targeted delivery for effective treatment of PCR.
Materials and Method: A liposomal based polymeric pH sensitive NP’s were prepared by utilizing LbL techniques. The NP’s were composed lipids, poly (b-amino ester) (PAE) and hyaluronic acid (HAC). The physiochemical properties of DRC-LbL NPs was evaluated such as particle size, zeta potential, percent entrapment efficiency (%EE), loading of drug and In-vitro drug release behavior. The surface morphology of LbL NP’s was evaluated by scanning electronic microscopy (SEM). The in vitro release of DRC-LbL-NP’s was determined by using Dialysis technique at pH 5 and 7.
Results: Results showed that developed DRC-LbL NP’s having average particle size of 182.94 + 4.11 nm, zeta potential (ZP) of -42.78± 3.2mV, higher drug entrapment efficiency (EE) of 74.94±3.45. The in-vitro drug release from DRC-LbL NP’s exhibited sustained release pattern and it was triggered by lower pH. The surface morphology of developed DRC-LbL NP’s exhibited smooth and uniform particle size in nano range. The results from in-vitro drug release showed that there was significant difference in amount of DRC release in both pH media. In phosphate buffer pH 7.4 the total amount of DRC release was found to be 44.82 % after 48 hour of study whereas in pH 5.0 it was recorded 98.24% after 48 hours.
Conclusion: The results from present study conclude that DRC-LbL NPs might be a promising candidate for the effective treatment of pancreatic cancer.
Keywords: Layer-by-layer, Nanoparticles, Doxorubicin, Controlled delivery, Targeted Delivery
Acemetacin in Acute and Chronic Pain Management
Authors: Berk Barkin 
Published: June 2023

Acemetacin is the carboxymethyl ester of indomethacin and is a pro-drug precursor compound, in other words, a prodrug. The pharmacologically active metabolite of acemetacin is also indomethacin. Acemetacin exerts its potent non-steroidal anti-inflammatory effects in the body as indomethacin. It is known that acemetacin is not only a prodrug of indomethacin, but also an agent with gastric protective mechanisms, possibly involving a reduction in leukocyte adhesion, and that acemetacin exerts gastric protective effects by exhibiting less efficacy on the COX-1 enzyme in the gastric mucosa compared to direct indomethacin use. It is clear that acemetacin is a valuable NSAID for acute and chronic pain.
Keywords: Acemetacin, indomethacin, non-steroidal anti-inflammatory drugs.
Comprehensive Assessment of Transcorneal Permeation, Antimicrobial, and Antifungal Activities of Andrographolide-Loaded Nanosuspension: In vitro and In vivo Studies
Authors: Mansuk Avinash G. , Pachpute Tejas S. 
Published: June 2023

This study aimed to comprehensively assess the transcorneal permeation, antimicrobial, and antifungal activities of a nanosuspension loaded with Andrographolide, a promising herbal compound. Through a combination of in vitro and in vivo studies, the efficacy, and potential applications of the nanosuspension in ocular drug delivery were investigated. In the in vitro phase, transcorneal permeation studies were conducted using Franz diffusion cells with excised rabbit corneas. The nanosuspension demonstrated significantly enhanced permeation compared to a control formulation, indicating its ability to effectively deliver Andrographolide through the cornea and into the ocular tissues. Additionally, the nanosuspension exhibited potent antimicrobial and antifungal activities against various ocular pathogens, as determined by agar diffusion and broth microdilution assays. Building upon the promising in vitro results, in vivo studies were performed using a rabbit model. Ocular tolerability of the nanosuspension was assessed through eye observations, with no observed signs of irritation or adverse effects. Furthermore, the nanosuspension's in vivo antimicrobial and antifungal activities were evaluated by instilling the formulation into the rabbits' eyes and monitoring conjunctival congestion and inflammation. The results demonstrated a significant reduction in conjunctival congestion, highlighting the nanosuspension's potential for combating ocular infections and inflammation. The comprehensive assessment presented in this study establishes the transcorneal permeation capability of the Andrographolide-loaded nanosuspension and its remarkable antimicrobial and antifungal activities. These findings underscore the potential of the nanosuspension as an effective ocular drug delivery system for various ocular infections and inflammatory conditions. The study contributes to the development of novel therapeutic approaches in ophthalmology, aiming to improve patient outcomes and provide alternative treatment options for ocular diseases.
Keywords: Transcorneal permeation; Nanosuspension; Andrographolide; Antimicrobial activity; Antifungal activity; Ocular drug delivery
Formulation and Evaluation of New Sustained Release Floating Microspheres of Cilnidipine by Solvent-Diffusion Evaporation Technique
Authors: Sharma Kritika , Thakur Priya , Agarwal Shweta 
Published: June 2023

The purpose of the present investigation was to develop a gastro-retentive cilnidipine loaded floating microspheres. The floating microspheres of cilnidipine were prepared by the solvent evaporation method for oral drug delivery using HPMCK4M and ethyl cellulose as polymers. The drug loaded microspheres were evaluated for particle size, drug content, entrapment efficiency and floating time. The in-vitro study was performed in pH 1.2 to determine the amount of drug released. Field emission scanning electron microscopy (SEM) was performed to check the surface morphology of microspheres. The mean particle size of the microspheres was in the range of 226.85 – 339.42µm. The drug content of the floating microspheres was more than 70% and drug entrapment efficiency of microspheres obtained between 64.64 – 83.0%. The in-vitro buoyancy was more than70%. Cumulative % of drug release obtained between 73.12 – 89.68%. Field emission scanning microscopy results showed that the prepared microspheres were smooth and spherical.The study reveals that more the particle size extended the floating time, this methods reveals that the drug content of the microspheres enhanced as the amount of polymer increased or increased in ethyl cellulose concentration also leads to increase in entrapment efficiency and particle size. Cumulative % drug release decreased as ethyl cellulose concentration increased.
Keywords: cilnidipine, microspheres, floating drug delivery system, entrapment efficiency, cumulative drug release, ethyl cellulose, Field emission scanning electron microscopy, polymer, concentration
Dental health education: Maintenance of dental health using flipchart media
Authors: Emini Emini 
Published: June 2023

Background: Dental and oral health maintenance is an effort to improve health. One of the reasons a person ignores dental and oral health problems is the lack of knowledge about dental and oral hygiene. Provision of dental and oral health knowledge should be given to school-age children. Efforts to increase knowledge are dental health counseling using flipchart media. Purpose: to analyze knowledge of dental and oral health maintenance before and after being given counseling using flipchart media for fifth grade students at SDN Tidung Island, 2022. Method: Pre-experimental research with pretest-posttest one group design. This research was conducted on 69 students of class V SDN on Tidung Island, who were obtained using a total sampling technique. The research instrument used a questionnaire and data analysis used the descriptive analysis. Results: The correct answers to the pre-test questions in the good category were 32 students with a percentage of 46.4%, in the sufficient category were 26 students with a percentage of 37.7%, and in the poor category were 11 students with a percentage of 15.9%. While the results of the correct answers to the post-test questions in the good category were 64 students with a percentage of 92.2%, the sufficient category was 5 students with a percentage of 7.2%, and the poor category was 0 with a percentage of 0%. Conclusion: there is a change in students' knowledge after being given dental health education using flipchart media.
Keywords: flipchart media, knowledge, dental health education.
Development and Validation of Stability Indicating Assay Method of Doxycycline Hyclate by using UV-Spectrophotometer
Authors: Sahoo Pradyumna Kumar , Sahoo Padmabhusana , Mohapatra Jagannath , Panigrahi Debadash , Patra Anup Kumar , Mishra Amiyakanta 
Published: June 2023

In the present study a simple, rapid, sensitive, and cost-effective stability indicating UV- spectrophotometric method was developed of doxycycline hyclate in bulk form and validated as per ICH guidelines. The stability-indicating study of doxycycline hyclate was based on the forced degradation reactions of the drug under different ICH-prescribed stress conditions like acid, alkali, neutral, oxidation, thermal, and photolysis. The absorption maximum of the drug was shown at 270nm and methanol was selected as solvent on the basis of the solubility of the drug. A linear relation with a regression coefficient value (R2) of 0.999 indicates that the method follows Beer’s- Lambert’s law within the concentrations range of 5 - 50µg/ml. The detection limit and quantitation limit were found to be 0.53 µg/ml and 1.55 µg/ml respectively. The % of recoveries was found to be within the range of 98.87 -99.88 with a low % of RSD indicating the accuracy of the method for estimation of the drug. Under stressed conditions, significant degradation was found in alkali, neutral and oxidation conditions and found to be sensitive under thermal and photolytic conditions but stable to acidic hydrolytic conditions. The developed method was validated according to ICH guidelines and found accurate, precise, and specific, suggesting that the developed stability-indicating spectroscopic method could be successfully adopted to estimate doxycycline hyclate.
Keywords: Doxycycline Hyclate; Stability Indicating method; UV spectrophotometer; Validation; Stress degradation.
Phytochemistry, Pharmacology and Unani traditional uses of Kasni (Cichorium intybus Linn.): A Review
Authors: Khatoon Shamshiya 
Published: June 2023

Kasni (Cichorium intybus Linn.) is highly praised in many traditional systems of medicine for medicinal properties of its leaves, seeds and roots. It is grown in Punjab, Kashmir, Andhra Pradesh, Karnataka and Maharashtra. In traditional medicine, all parts of the plant are used as diuretic, laxative, antibilious, antipyretic, blood purification, appetizer and strengthen of the stomach. It is also used in the treatment of hepatic failure, jaundice, intermittent fever and mild states of chronic skin diseases. It contains glycosides, flavonoids, saponins, caffeic acid derivatives, inulin, lactucin, sonchuside A, cichoriolide. The scientific analysis of kasni demonstrates many of the activities mentioned in Unani literature. Nevertheless, further research is needed to identify the mechanism, active constituent, and usefulness of kasni in clinical practice. Given the encouraging results against neurological disorders in the prefaces, this aspect should be thoroughly investigated to make it a standard medicine.
Keyword: Kasni; Hepatoprotective; Unani medicine; esculatin
Formulation and Evaluation of Oral Soft Jelly Containing Salbutamol Sulphate for the Treatment of Asthma
Authors: Honale Vaishnavi Sanjay , Muneshwar Shraddha Dilip , Sawale Amol V 
Published: June 2023

Salbutamol sulphate oral soft jelly in asthma has been formulated and evaluated as the goal of the current investigation. A person with asthma has inflamed, narrowed, swollen, and excess mucus-producing airways, which makes breathing difficult. Salbutamol is used to treat asthma and chronic obstructive pulmonary disease (COPD.It works by relaxing the muscle of the airways into the lungs, which makes it easier to breathe . It functions by loosening the muscles in the lungs' airways, which facilitates breathing. Salbutamol is available as an inhaler, tablets, and certain liquid oral dose forms, but due to patient noncompliance issues, oral jellies containing salbutamol sulphate were developed. This study's aim is to create oral jelly, which by avoiding first pass effect, promotes patient compliance and bioavailability while avoiding many negative effects of conventional dosage forms Salbutamol sulphate oral jelly is simple to swallow and improves patient compliance in paediatric patients. Many paediatric patients find it difficult to swallow tablets and capsules, as well as to use the salbutamol inhalation in cases of asthma. The best In vitro medication release was demonstrated by the salbutamol sulphate oral jelly (F2) batch at 85% in 60 minutes. The drug concentration was discovered to be between 98.23% and 99.25%, which was within the pharmacopoeial range of 98% to 101%. Salbutamol sulphate's UV spectra were examined, and it was discovered that its greatest absorption occurs at 217.50 nm. The cost-effective salbutamol sulphate oral soft jelly also demonstrated improved compliance and an increase in bioavailability.
Keywords: Oral Jelly, Asthma, Patient Compliance, Salbutamol Sulphate, Paediatric Patients
Evaluation of Anti-Diabetic Activity of Silver Nanoparticles Synthesized from Ethanolic Extract of Phyllanthus niruri on Wistar Rats
Authors: Kotaru Manvitha , Korimelli Sridevi 
Published: June 2023

Diabetes is a metabolic disorder characterized by hyperglycemia resulting from either the deficiency in insulin secretion or the action of insulin Diabetes can affect numerous different organ systems in the body and, over time, can lead to serious complications. Complications are microvascular or macrovascular. To evaluate the anti-diabetic effect of Phyllanthus niruri silver nano-particles. Streptozotocin (STZ) of 50mg/kg is used to induce diabetes in wistar rats. The wistar rats were distributed to six different groups. Group-I represented as Control; Group-II represented as diabetic control (STZ ); Group-III represented as 5 mg/kg body weight of glibenclamide + diabetes; Group-IV represented as phyllanthus niruri extract + diabetes; Group-V represented as 100 µg Phyllanthus niruri silver nanoparticles + diabetes; group-6- Phyllanthus niruri silver nanoparticles150µg + diabetes. The silver nanoparticles were inspected for the morphological and optical properties investigated using UV spectrophotometer, SEM and FT-IR techniques. The AgNPs has shown characteristic peak at 428nm.The study revealed that the AgNPs treatment reduced serum blood glucose concentrations remarkable improvement in the body weight, Abnormal high serum levels in diabetes treatment with AgNp’s they reached to normal in STZ-challenged diabetic rats. The histo-pathological alterations were also studied in all the experimental animals. The pathology results revealed that the AgNPs treatment induces the regeneration of islets cells of pancreas in the experimental rats. The research study proved that the Phyllanthus niruri AgNPs exerts anti-diabetic properties.
Keywords: Diabetes, STZ, Phyllanthus niruri, silver nanoparticles
Glucose adsorption capacity and inhibitory potential of Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae) leaf extracts against α-amylase: a comparative study over three months
Authors: SANOU Yacouba , OUATTARA Lassina , KABRE Pawendé , OUEDRAOGO Relwendé Justin , OUOBA Paulin , ZANTE Abdoul Aziz , ZOUNGO Daouda , SOMDA Martin Bienvenu , OUEDRAOGO Anicet Georges 
Published: June 2023

Objective(s): The aim of this study was to evaluate the antidiabetic potential of Pseudocedrela kotschyi leaf decoction by making a comparison between extracts harvested over three months.
Design: This study is done through a few experiences. After the quantification of total polyphenols by folin-Ciocalteu reagent method, the antioxidant activities were tested with ABTS, DPPH and FRAP essays. Then, the glucose oxidase kit was used to determine the glucose adsorption capacity of the extracts. At last, dinitrosalicylic acid method served to evaluate the α-amylase inhibitory activity of the extracts.
Results: As results the leaves extracts of Pseudocedrela kotschyi showed a polyphenol content of 39,97 ± 3,63 mg EAG/g DE for October, 74,2 ± 11,64 for November and 59,45 ± 7,024 for December. For total flavonoids, the content was 4,86 ± 0,29 mg QE/g DE (October) 5,68 ± 0,39 mg QE/g DE (November) and 5,548 ± 0,19 mg QE/g DE (December). In addition, the antioxidant activity was correlated with the phenolic content (r = -0.65 for DPPH IC50, r = -0.84 for ABTS IC50 and r = 0.97 for FRAP). Besides, the extracts exhibited a strong α-amylase inhibitory activity (IC50 = 0,272 mg DE/mL for October, 0,097 mg DE/mL for November and 0,101 mg DE/mL for December) and had a high capacity to adsorb glucose (over 219,98 ±2,54mmol/g DE for a 30mM glucose solution for November).
Conclusion: Pseudocedrela kotschyi leaf decoction has the ability to inhibit α-amylase activity and adsorb glucose in glucose concentrated solution. So it possess a high antidiabetic potential.
Keywords: Glucose adsorption, α-amylase, Pseudocedrela kotschyi, antioxidant activity.