bluuebunny/crossref_metadata_2025_split huggingface dataset:
An exploration of how adolescents experience and reason their parents' comments on their weight, shape, and eating
Authors: Dahill Lucy M. , Morrison Natalie M. V. , Touyz Stephen , Mitchison Deborah , Bussey Kay , Mannan Haider , Hay Phillipa 
Published: July 2023

AbstractIntroductionDisordered eating among adolescents is of increasing concern given associated physical and mental health sequelae. Cognitions underlying disordered eating are formed in childhood and adolescence. Parents are a significant presence during this period, so it is critical to understand how they influence their adolescent's eating cognitions and behaviors.MethodsQualitative analysis using interpretative phenomenological analysis (IPA) methodology was employed to consider the lived experiences of 10 Australian adolescents (14–19 years), 60% female, as they engaged with their parents in a range of weight, shape, and eating communications.ResultsOur inductive IPA revealed three key themes representing adolescents' experiences and meaning‐making: Parents as Influencers—adolescents acknowledged parents are influencers (objects) within a wider context of community and cultural norms (symbols) and can be protective for peer influence on body image ideals; Expression and Perception—the “what” (weight‐talk as an object) and the “how” (objects as independent influences) of gendered parental communication related to health and fitness ideals and illustrated diverse interpretations of both verbal and non‐verbal expression; and Fertile Soil and Maturity—the adolescent's characteristics and context influence perceptions of communication, a fear of deviating from norms, and an overarching focus on being “healthy” yet not always knowing what that was. Perception of bidirectional communication also offered valuable insights into potential dangers through family loyalty and in‐group permissions.ConclusionsFindings highlight implications for the nuanced influence of parental communication and illustrate the pivotal role of parents within the bioecosystem of adolescent development.
The Effect of Free and Protein‐Bound Maillard Reaction Products N‐ε‐Carboxymethyllysine, N‐ε‐Fructosyllysine, and Pyrraline on Nrf2 and NFκB in HCT 116 Cells
Authors: Raupbach Jana , Müller Stephan K. , Schnell Vanessa , Friedrich Suse , Hellwig Anne , Grune Tilman , Henle Thomas 
Published: July 2023

ScopeMaillard reaction products (MRPs) are believed to interact with the receptor for advanced glycation endproducts (RAGE) and lead to a pro‐inflammatory cellular response. The structural basis for this interaction is scarcely understood. This study investigates the effect of individual lysine modifications in free form or bound to casein on human colon cancer cells.Methods and resultsSelectively glycated casein containing either protein‐bound N‐ε‐carboxymethyllysine (CML), N‐ε‐fructosyllysine (FL), or pyrraline is prepared and up to 94%, 97%, and 61% of lysine modification could be attributed to CML, FL, or pyrraline, respectively. HCT 116 cells are treated with free CML, pyrraline, FL, or modified casein for 24 h. Native casein is used as control. Intracellular MRP content is analyzed by UPLC‐MS/MS. Microscopic analysis of the transcription factors shows no activation of NFκB by free or protein‐bound FL or CML, whereas casein containing protein‐bound pyrraline activates Nrf2. RAGE expression is not influenced by free or casein‐bound MRPs. Activation of Nrf2 by pyrraline‐modified casein is confirmed by analyzing Nrf2 target proteins NAD(P)H dehydrogenase (quinone 1) (NQO1) and heme oxygenase‐1 (HO‐1).ConclusionStudies on the biological effects of glycated proteins require an individual consideration of defined structures. General statements on the effect of “AGEs” in biological systems are scientifically unsound.
Crushing behavior of CFRP/AL hybrid tubes under oblique lateral loading
Authors: Yang Hongyuan , Ren Yiru 
Published: July 2023

AbstractThis work aims to research the oblique lateral crushing behavior of CFRP/AL hybrid tubes under different parameter configurations. First, a finite element model was established based on the maximum stress criterion and the traction‐separation law. The reliability of the numerical models for pure aluminum, pure composite, and hybrid tubes was verified by rigorous comparison with experimental data, respectively. Second, the influence of loading conditions and geometric characteristics on crashworthiness were studied. The results show that the damage modes of the hybrid tube under oblique lateral loading are mainly concentrated in the horizontal and vertical ends, specifically in the form of plastic hinge and fiber, matrix fracture. The CFRP layers has positive effect on improving the specific energy absorption (SEA). High ratio thickness of aluminum tubes can effectively improve the energy absorption (EA) and crush force efficiency (CFE). It is found that the sandwich structure is not conducive to resist lateral crushing, while the CFRP without external constraints can absorb more impact energy.Highlights
The oblique lateral crushing behavior of CFRP/AL hybrid tube was studied.
A numerical simulation method was proposed and verified.
The effects of loading angle, fiber layers and AL thickness were studied.
The hybrid ratio and hybrid method were designed and discussed.
Plasma medicine: The era of artificial intelligence
Authors: Ercan Utku Kürşat , Özdemir Gizem Dilara , Özdemir Mehmet Akif , Güren Onan 
Published: July 2023

AbstractThe current trends that incorporate artificial intelligence (AI) and medicine have created new opportunities for improvement in both early diagnosis and treatment of diseases. In this framework, AI might also have the potential to significantly revolutionize the way we approach the field of plasma medicine, an area that is quickly growing and uses cold atmospheric plasma (CAP) to address a variety of medical conditions. Plasma medicine offers promising therapeutic alternatives for conditions widely ranging from cancer treatment to wound healing and antimicrobial applications, but the complexity of the plasma sources and the huge number of parameters may be overwhelming for the determination of underlying mechanisms and for understanding the effect of the source. This is where AI steps in, to provide strong tools for modeling, evaluating, and controlling CAPs. By harnessing the power of AI, researchers in the plasma medicine area, are now able to evaluate massive volumes of data, enhance their treatment protocols, and predict treatment results with a level of precision never possible before. Hereby, we emphasized the potential and further utilization of AI in plasma medicine in light of the fascinating and recent developments in this cooperation. New opportunities are encouraging, but potential limitations, ethical issues, model transparency, and generalizability should be considered. Regardless, the possibilities are endless, and the future of plasma medicine is looking brighter than ever with the implementation of AI.
Higher Education in Brazil: Institutional Actions for the Retention of Students in Public and Private Sectors
Authors: Barbosa Maria-Ligia , Borges Eduardo Henrique Narciso , Gouvea Adriane , Picanço Felícia , Rodrigues Leonardo , Vieira André 
Published: July 2023

AbstractThis study examines responses to the COVID-19 pandemic among different sectors and types of institutions in the Brazilian higher education system. We aim to analyse how institutions faced the pandemic; what policies or institutional actions were proposed; and by which institutions/institutional types? What rationales justify these proposals? Are there similarities among actions? Based on the concepts of institutional logics and embedded institutional agency, empirical narratives collected in documents from institutions and previous research were organised to make sense of otherwise disparate initiatives. Drawing upon the literature on institutional positioning in higher education and using the latest Brazilian national higher education census, we built a typology of institutions focusing on four dimensions associated with policy responses to the pandemic: the educational profile, research involvement, structural characteristics of institutions, and social inclusion policies. We further complement the data set on the institutional landscape of higher education with institutional documents, interviews, and reports, as well as the extensive news coverage collected by students and researchers at Laboratory for Research into Higher Education (LAPES), in order to provide the empirical elements for the analysis of policies and institutional actions.
Detection of Fusobacterium nucleatum in Patients with Colitis-Associated Colorectal Cancer
Authors: Dregelies Theresa , Haumaier Franziska , Sterlacci William , Backert Steffen , Vieth Michael 
Published: July 2023

AbstractFusobacterium nucleatum is supposed to play a critical role in the development of colorectal cancer. The species has also been associated with ulcerative colitis (UC) that can progress into colorectal cancer, however, the involvement of bacteria in this process remains unclear. We analysed 177 colon biopsies obtained from patients during screening, including 20 healthy controls, 56 UC cases and 69 cases at different stages of progression to colitis-associated cancer (CAC); 32 samples of sporadic colorectal carcinoma (sCRC) were also included. The presence of F. nucleatum was detected by quantitative real-time PCR (qPCR). Our data show an association between the presence of the bacteria and the progression of carcinogenesis in UC patients. In 39.5% of CAC samples F. nucleatum was detected, compared to only 1.8% in UC cases. The bacteria were detected in 6.3% of samples with initial neoplastic transformation, so-called low-grade dysplasia (LGD), whereas high-grade dysplasia (HGD) resulted in 33.3% of samples positive for F. nucleatum. The fraction of F. nucleatum-positive samples from sCRC cases was 56.3%, which was not significantly different to the CAC group. We conclude that F. nucleatum is associated with the occurrence and progression of colon carcinogenesis, rather than with UC itself.
INFRAFRONTIER: mouse model resources for modelling human diseases
Authors: Ali Khan Asrar , Valera Vazquez Gema , Gustems Montse , Matteoni Rafaele , Song Fei , Gormanns Philipp , Fessele Sabine , Raess Michael , Hrabĕ de Angelis Martin ,   the INFRAFRONTIER Consortium
Published: July 2023

AbstractOver the last decade, INFRAFRONTIER has positioned itself as a world-class Research Infrastructure for the generation, phenotyping, archiving, and distribution of mouse models in Europe. The INFRAFRONTIER network consists of 22 partners from 15 countries, and is continuously enhancing and broadening its portfolio of resources and services that are offered to the research community on a non-profit basis. By bringing together European rodent model expertise and providing valuable disease model services to the biomedical research community, INFRAFRONTIER strives to push the accessibility of cutting-edge human disease modelling technologies across the European research landscape. This article highlights the latest INFRAFRONTIER developments and informs the research community about its extensively utilised services, resources, and technical developments, specifically the intricacies of the INFRAFRONTIER database, use of Curated Disease Models, overview of the INFRAFRONTIER Cancer and Rare Disease resources, and information about its main state-of-the-art services.
Graphical abstract
Comparing linear and non-linear models to estimate the appropriate cochlear implant electrode array length—are current methods precise enough?
Authors: Weiss Nora M. , Breitsprecher Tabita , Wozniak Martin , Bächinger David , Völter Christiane , Mlynski Robert , Van de Heyning Paul , Van Rompaey Vincent , Dazert Stefan 
Published: July 2023

Abstract
Purpose
In cochlear implantation with flexible lateral wall electrode arrays, a cochlear coverage (CC) range between 70% and 80% is considered ideal for optimal speech perception. To achieve this CC, the cochlear implant (CI) electrode array has to be chosen according to the individual cochlear duct length (CDL). Here, we mathematically analyzed the suitability of different flexible lateral wall electrode array lengths covering between 70% and 80% of the CDL.

Methods
In a retrospective cross-sectional study preoperative high-resolution computed tomography (HRCT) from patients undergoing cochlear implantation was investigated. The CDL was estimated using an otosurgical planning software and the CI electrode array lengths covering 70–80% of the CDL was calculated using (i) linear and (ii) non-linear models.

Results
The analysis of 120 HRCT data sets showed significantly different model-dependent CDL. Significant differences between the CC of 70% assessed from linear and non-linear models (mean difference: 2.5 mm, p < 0.001) and the CC of 80% assessed from linear and non-linear models (mean difference: 1.5 mm, p < 0.001) were found. In up to 25% of the patients none of the existing flexible lateral wall electrode arrays fit into this range. In 59 cases (49,2%) the models did not agree on the suitable electrode arrays.

Conclusions
The CC varies depending on the underlying CDL approximation, which critically influences electrode array choice. Based on the literature, we hypothesize that the non-linear method systematically overestimates the CC and may lead to rather too short electrode array choices. Future studies need to assess the accuracy of the individual mathematical models.
Impact of encorafenib on survival of patients with BRAFV600E-mutant metastatic colorectal cancer in a real-world setting
Authors: Zurloh M. , Goetz M. , Herold T. , Treckmann J. , Markus P. , Schumacher B. , Albers D. , Rink A. , Rosery V. , Zaun G. , Kostbade K. , Pogorzelski M. , Ting S. , Schmidt H. , Stiens R. , Wiesweg M. , Schuler M. , Kasper Stefan , Virchow I. 
Published: July 2023

Abstract
Purpose
Patients with BRAFV600E-mutant metastatic colorectal cancer (mCRC) have a dismal prognosis. The best strategies in these patients remain elusive. Against this background, we report the clinical course of patients with BRAFV600E-mutant mCRC to retrieve the best treatment strategy.

Patients and methods
Clinico-pathological data were extracted from the electronic health records. Kaplan–Meier method was used to estimate overall (OS) and progression-free survival (PFS). Objective response rate (ORR) was assessed according to RECIST 1.1.

Results
In total, 51 patients were enrolled. FOLFOXIRI was administered to 12 patients; 29 patients received FOLFOX or FOLFIRI as first-line treatment. Median OS was 17.6 months. Median PFS with FOLFOXIRI (13.0 months) was significantly prolonged (HR 0.325) as compared to FOLFOX/FOLFIRI (4.3 months). However, this failed to translate into an OS benefit (p = 0.433). Interestingly, addition of a monoclonal antibody to chemotherapy associated with superior OS (HR 0.523). A total of 64.7% patients received further-line therapy, which included a BRAF inhibitor in 17 patients. Targeted therapy associated with very favourable OS (25.1 months).

Conclusion
Patients with BRAFV600E-mutated mCRC benefit from the addition of an antibody to first-line chemotherapy. Further-line treatment including a BRAF inhibitor has a dramatic impact on survival.
The role of surgery in the treatment of neuroblastoma metastases at rare sites
Authors: Scherer Simon , Mayer Benjamin F. B. , Dietzel Markus , Esser Michael , Warmann Steven W. , Lang Peter , Schuhmann Martin U. , Schmidt Andreas , Fuchs Jörg 
Published: July 2023

Abstract
Purpose
Treatment of neuroblastoma metastases usually consists of chemotherapy and irradiation. However, in selected cases, surgical treatment is also indicated. In this study, we present three cases of patients with neuroblastoma metastases at rare sites that underwent surgery.

Materials and methods
We retrospectively analyzed data of patients who underwent surgery for neuroblastoma at our department of Pediatric Surgery and Pediatric Urology at the University Children’s Hospital in Tuebingen and selected those patients who had surgery explicitly for a metastasis.

Results
Between 2002 and 2020, 277 children underwent surgical treatment for neuroblastoma. Three cases with metastases at exceptional sites are presented here after therapy according to protocols. One patient had a penile metastasis and received surgery including a plastic reconstruction. The patient showed no signs of erectile or urinary dysfunction at follow-up. Another patient had a metastasis in the proximal ulna, which remained vital even after exhausted treatment after two relapses. Afterward there was no restriction of movement of the extremity. The third patient had, amongst others, metastases to the pancreatic body and to the liver. Both were surgically removed during primary tumor resection. This patient died after local tumor relapse. The other two patients showed no evidence of tumor relapse after a follow-up of 18 and 17 months, respectively.

Conclusion
Although children with neuroblastoma often present with metastases, there is no recommendation for surgical treatment other than diagnostic biopsies. In case of persistence of metastasis or after exhaustion of high-risk therapy, surgical resection must be considered.
A Systematic Analysis of Additive Manufacturing Techniques in the Bioengineering of In Vitro Cardiovascular Models
Authors: Mohanadas Hemanth Ponnambalath , Nair Vivek , Doctor Akbar Abbas , Faudzi Ahmad Athif Mohd , Tucker Nick , Ismail Ahmad Fauzi , Ramakrishna Seeram , Saidin Syafiqah , Jaganathan Saravana Kumar 
Published: July 2023

AbstractAdditive Manufacturing is noted for ease of product customization and short production run cost-effectiveness. As our global population approaches 8 billion, additive manufacturing has a future in maintaining and improving average human life expectancy for the same reasons that it has advantaged general manufacturing. In recent years, additive manufacturing has been applied to tissue engineering, regenerative medicine, and drug delivery. Additive Manufacturing combined with tissue engineering and biocompatibility studies offers future opportunities for various complex cardiovascular implants and surgeries. This paper is a comprehensive overview of current technological advancements in additive manufacturing with potential for cardiovascular application. The current limitations and prospects of the technology for cardiovascular applications are explored and evaluated.
Predictive value of forearm muscle oxygenation parameters for climbing-specific finger endurance and competitive climbing performance
Authors: Winkler Marvin , Künzell Stefan , Augste Claudia 
Published: July 2023

Abstract
Purpose
Near-infrared spectroscopy (NIRS) is a valid and reliable method to assess forearm muscle oxygenation in sport climbing, focusing on evaluating single parameters. The study assessed the predictive value of various NIRS parameters in climbing-specific settings, during intermittent finger endurance testing and in a simulated climbing competition.

Methods
52 recreational climbers (28.5 ± 6.3 y) performed an intermittent finger endurance test and 10 competitive climbers (20.2 ± 6.3 y) participated in a simulated lead climbing competition. Continuous-wave NIRS were used to assess oxygenation and blood volume changes.

Results
NIRS parameters predicted 26.4% of the variance in the intermittent test, with mean minima and maxima of O2Hb and mean maxima of TSI% of the single repetitions being the predictors. No significant differences existed between the last valid and the first nonvalid repetition on the combined dependent variable. For the simulated competition, a statistically significant difference between the 20 s intervals on the combined dependent variables was found with posthoc testing showing significant univariate within-subjects effects for HHb, tHb & TSI, but not for O2Hb.

Conclusion
The results indicate that for the intermittent test, high re- and deoxygenation abilities, and for the climbing competition, the accumulation of HHb concentration levels have the highest predictability.
Biomechanical characterisation of the pull-up exercise
Authors: Garavaglia Lorenzo , Romanò Jacopo , Lazzari Fabio , Pittaccio Simone 
Published: July 2023

Abstract
Purpose
Performance is the benchmark to assess the level of an athlete: in this respect, a more precise qualitative and quantitative evaluation of the performance represents an important target to be achieved.

Methods
The work presents a possible method, based on the biomechanical evaluation of the motor exercise with an optoelectronic system, to characterise single or multiple repetitions of pull-ups of 12 athletes of sport climbing and sportive healthy subjects, monitoring and scoring the performance and the safety of the executions. The analysis includes the time courses of the segmental kinematics and some newly developed synthetic indices in the form of performance and safety scores.

Results
The time courses make it possible to analyse the linear and angular kinematics district-by-district and have a direct overview of the ranges of motion, the patterns of task execution, together with the possible strategies adopted to complete the exercise in terms of compensations. The proposed characterisation provides a condensed summary of the global execution quality and offers the possibility to identify which single biomechanical parameters are modified.

Conclusion
The method is intended as a practical tool to enrich the training schedule in terms of the qualitative and quantitative evaluation of the performances and to increase the self-awareness while training.
Surface and subsurface structural mapping for delineating the active emergency spillway fault, Aswan, Egypt, using integrated geophysical data
Authors: El Bohoty Mohamed , Ghamry Essam , Hamed Ahmed , Khalifa Mohamed , Taha Ayman , Meneisy Ahmed 
Published: July 2023

AbstractThe High Dam is one of the world’s biggest embankments dams. Moreover, the new city of Aswan, which locates on the western side of the Nile River, is one of the cities that was established to overcome the growing population problem. Therefore, the detailed geophysical studies for the active faults are of more importance for assessing the seismic stability for both of them. Indeed, the emergency spillway fault was documented as a normal and inactive fault. While, a moderate earthquake (ML = 4.6) was recorded along this fault in 2010, about 4.5 km away from the Dam. Hence, its activity must be re-evaluated. The seismic activity along the fault and its extension has been studied. The seismicity distributions and the fault plane solution indicate normal faulting with a strike-slip component and shallow focal depth. Moreover, pore pressure and fluid diffusion play an essential role in fault activation process. On the other hand, the magnetic data for the research area was subjected to a detailed analysis. 2D spectrum analysis and 3D Euler deconvolution methods, were used to analyze and interpret the aeromagnetic anomaly data so as to better understand the tectonic framework of the study region. Finally, the integrated geophysical data delineate the trend of the emergency spillway fault which extends NW–SE. This fault could assist in updating the current seismic source model around the High Dam and new Aswan city for evaluating the seismic hazard for both of them.