bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interfacial Micro‐Environment of Electrocatalysis and Its Applications for Organic Electro‐Oxidation Reaction
Authors: Liu Yi , Yang Zhihui , Zou Yuqin , Wang Shuangyin , He Junying 
Published: September 2023

AbstractConventional designing principal of electrocatalyst is focused on the electronic structure tuning, on which effectively promotes the electrocatalysis. However, as a typical kind of electrode–electrolyte interface reaction, the electrocatalysis performance is also closely dependent on the electrocatalyst interfacial micro‐environment (IME), including pH, reactant concentration, electric field, surface geometry structure, hydrophilicity/hydrophobicity, etc. Recently, organic electro‐oxidation reaction (OEOR), which simultaneously reduces the anodic polarization potential and produces value‐added chemicals, has emerged as a competitive alternative to oxygen evolution reaction, and the role IME played in OEOR is receiving great interest. Thus, this article provides a timely review on IME and its applications toward OEOR. In this review, the IME for conventional gas‐involving reactions, as a contrast, is first presented, and then the recent progresses of IME toward diverse typical OEOR are summarized; especially, some representative works are thoroughly discussed. Additionally, cutting‐edge analytical methods and characterization techniques are introduced to comprehensively understand the role IME played in OEOR. In the last section, perspectives and challenges of IME regulation for OEOR are shared.
Applications of Boron Cluster Supramolecular Frameworks as Metal‐Free Chemodynamic Therapy Agents for Melanoma
Authors: Xu Xiaoran , Deng Xuefan , Li Yi , Xia Shiying , Baryshnikov Glib , Bondarchuk Sergey V. , Ågren Hans , Wang Xinyu , Liu Pan , Tan Yujia , Huang Tianhe , Zhang Haibo , Wei Yongchang 
Published: September 2023

AbstractChemodynamic therapy (CDT) is a highly targeted approach to treat cancer since it converts hydrogen peroxide into harmful hydroxyl radicals (OH·) through Fenton or Fenton‐like reactions. However, the systemic toxicity of metal‐based CDT agents has limited their clinical applications. Herein, a metal‐free CDT agent: 2,4,6‐tri(4‐pyridyl)‐1,3,5‐triazine (TPT)/ [closo‐B12H12]2−(TPT@ B12H12) is reported. Compared to the traditional metal‐based CDT agents, TPT@B12H12 is free of metal avoiding cumulative toxicity during long‐term therapy. Density functional theory (DFT) calculation revealed that TPT@B12H12 decreased the activation barrier more than 3.5 times being a more effective catalyst than the Fe2+ ion (the Fenton reaction), which decreases the barrier about twice. Mechanismly, the theory calculation indicated that both [B12H12]−· and [TPT‐H]2+ have the capacity to decompose hydrogen into 1O2, OH·, and O2−·. With electron paramagnetic resonance and fluorescent probes, it is confirmed that TPT@B12H12 increases the levels of 1O2, OH·, and O2−·. More importantly, TPT@B12H12 effectively suppress the melanoma growth both in vitro and in vivo through 1O2, OH·, and O2−· generation. This study specifically highlights the great clinical translational potential of TPT@B12H12 as a CDT reagent.
The lived experience of depression: a bottom‐up review co‐written by experts by experience and academics
Authors: Fusar‐Poli Paolo , Estradé Andrés , Stanghellini Giovanni , Esposito Cecilia Maria , Rosfort René , Mancini Milena , Norman Peter , Cullen Julieann , Adesina Miracle , Jimenez Gema Benavides , da Cunha Lewin Caroline , Drah Esenam A. , Julien Marc , Lamba Muskan , Mutura Edwin M. , Prawira Benny , Sugianto Agus , Teressa Jaleta , White Lawrence A. , Damiani Stefano , Vasconcelos Candida , Bonoldi Ilaria , Politi Pierluigi , Vieta Eduard , Radden Jennifer , Fuchs Thomas , Ratcliffe Matthew , Maj Mario 
Published: September 2023

We provide here the first bottom‐up review of the lived experience of depression, co‐written by experts by experience and academics. First‐person accounts within and outside the medical field were screened and discussed in collaborative workshops involving numerous individuals with lived experience of depression, family members and carers, representing a global network of organizations. The material was enriched by phenomenologically informed perspectives and shared with all collaborators in a cloud‐based system. The subjective world of depression was characterized by an altered experience of emotions and body (feeling overwhelmed by negative emotions, unable to experience positive emotions, stuck in a heavy aching body drained of energy, detached from the mind, the body and the world); an altered experience of the self (losing sense of purpose and existential hope, mismatch between the past and the depressed self, feeling painfully incarcerated, losing control over one's thoughts, losing the capacity to act on the world; feeling numb, empty, non‐existent, dead, and dreaming of death as a possible escape route); and an altered experience of time (experiencing an alteration of vital biorhythms, an overwhelming past, a stagnation of the present, and the impossibility of the future). The experience of depression in the social and cultural context was characterized by altered interpersonal experiences (struggling with communication, feeling loneliness and estrangement, perceiving stigma and stereotypes), and varied across different cultures, ethnic or racial minorities, and genders. The subjective perception of recovery varied (feeling contrasting attitudes towards recovery, recognizing recovery as a journey, recognizing one's vulnerability and the need for professional help), as did the experience of receiving pharmacotherapy, psychotherapy, and social as well as physical health interventions. These findings can inform clinical practice, research and education. This journey in the lived experience of depression can also help us to understand the nature of our own emotions and feelings, what is to believe in something, what is to hope, and what is to be a living human being.
Nonlinear oscillation of a microbeam due to an electric actuation—Comparison of approximate models
Authors: Andrianov Igor V. , Awrejcewicz Jan , Koblik Steve G. , Starushenko Galina A. 
Published: September 2023

AbstractIn this paper, oscillations of the electrically actuated microbeam are considered, described by strongly nonlinear differential equations. One of the essentially nonlinear effects is the pull‐in phenomenon, that is, the transition of the oscillatory regime to the attraction regime. This effect is considered in the paper on the basis of various approximate models. In particular, the error of replacing the original nonlinearity by its expansion in the Maclaurin series is estimated. It is shown that such an approximation can only be used for voltage values that are far from critical. Estimates are also given for initial displacements and velocities, which guarantee an oscillating character of solutions. The electrically activated oscillations of the microbeam are considered taking into account the geometric nonlinearity within the framework of the Kirchhoff model. The dependence of pull‐in value on geometric nonlinearity is investigated.
Analytical calculation of stress intensity factors for orthotropic plates containing cracks emanating from a circular hole using Schwarz integration
Authors: Moussavian Seyyed Hassan , Jafari Mohammad , Hajimohammadi Mojtaba 
Published: September 2023

AbstractIn this paper, a new analytical method is presented to determine the stress intensity factors (SIFs) of a generally orthotropic plate with cracks emanating from a circular hole. Therefore, using the Schwartz integration method, for the first time, the analytical solution is provided based on the complex variable method. In order to use the Schwartz's theorem in solving complex integrals, a new presentation of the mapping function has been presented, which leads to providing a simpler solution. After calculating the potential functions, the SIFs are determined for the circular hole with one and two cracks. Then, the effect of parameters such as fiber angle, different and unequal crack lengths, and different loadings are studied. To validate the results of the present analytical solution, some results have been compared with the results from other references. Comparing the results showed that the current solution has good accuracy and is reliable and the fiber angle has a significant effect on the mode II SIF. In the case that the fibers are along the crack length and the loading is perpendicular to the crack direction, the mode II SIF is zero, but if the fibers are not along the crack length, the value of the mode II SIF will not be zero. It is also shown that increasing the length of one crack increases the SIF of another crack as well.
Automatic Determination of the SLR Reference Point at Côte d’Azur Multi-Technique Geodetic Observatory
Authors: Barnéoud Julien , Courde Clément , Beilin Jacques , Germerie-Guizouarn Madec , Pesce Damien , Vidal Maurin , Collilieux Xavier , Maurice Nicolas 
Published: September 2023

AbstractThe Satellite Laser Ranging (SLR) station known as GRSM-7845 in the International Laser Ranging Service (ILRS) is hosted by the Observatoire de la Côte d’Azur (OCA) located in Caussols, France. Its reference point is the intersection of the telescope axes, which is supposed to be static. Measuring devices and a data processing chain were set up to automatically determine this point, more quickly and accurately than traditional local survey. In order to use an indirect approach (circular fitting), circular and motorized prisms were fixed on the station to be always visible during the telescope rotation. A software package was developed to control the telescope, the dome and the total station motions for fully automatic measurements. In addition to providing an easy determination of the cross-axis for local ties, this system will allow to study the potential motion of the telescope’s axes intersection throughout the year.
Improved prediction of long-term kidney outcomes in people with type 2 diabetes by levels of circulating haematopoietic stem/progenitor cells
Authors: Bonora Benedetta Maria , Morieri Mario Luca , Marassi Marella , Cappellari Roberta , Avogaro Angelo , Fadini Gian Paolo 
Published: September 2023

Abstract
Aim/hypothesis
We examined whether prediction of long-term kidney outcomes in individuals with type 2 diabetes can be improved by measuring circulating levels of haematopoietic stem/progenitor cells (HSPCs), which are reduced in diabetes and are associated with cardiovascular risk.

Methods
We included individuals with type 2 diabetes who had a baseline determination of circulating HSPCs in 2004–2019 at the diabetes centre of the University Hospital of Padua and divided them into two groups based on their median value per ml of blood. We collected updated data on eGFR and albuminuria up to December 2022. The primary endpoint was a composite of new-onset macroalbuminuria, sustained ≥40% eGFR decline, end-stage kidney disease or death from any cause. The analyses were adjusted for known predictors of kidney disease in the population with diabetes.

Results
We analysed 342 participants (67.8% men) with a mean age of 65.6 years. Those with low HSPC counts (n=171) were significantly older and had a greater prevalence of hypertension, heart failure and nephropathy (45.0% vs 33.9%; p=0.036), as evidenced by lower eGFR and higher albuminuria at baseline. During a median follow-up of 6.7 years, participants with high vs low HSPC counts had lower rates of the composite kidney outcome (adjusted HR 0.69 [95% CI 0.49, 0.97]), slower decline in eGFR and a similar increase in albuminuria. Adding the HSPC information to the risk score of the CKD Prognosis Consortium significantly improved discrimination of individuals with future adverse kidney outcomes.

Conclusions/interpretation
HSPC levels predict worsening of kidney function and improve the identification of individuals with type 2 diabetes and adverse kidney outcomes over and beyond a clinical risk score.

Graphical Abstract
High body mass index is not a contraindication for an arthroscopic ligament repair with biological augmentation in case of chronic ankle instability
Authors: Guiraud Kevin , Nunes Gustavo Araujo , Vega Jordi , Cordier Guillaume 
Published: September 2023

AbstractPurposeObesity remains frequently mentioned as a contraindication for lateral ankle ligament repair. The aim of the study was to compare the clinical results of an arthroscopic lateral ligament repair with biological augmentation between patients with a body mass index (BMI) of more than 30 and less than 30.MethodsSixty‐nine patients with an isolated lateral ankle instability were treated with an arthroscopic anterior talofibular ligament (ATFL) repair with biological augmentation using the inferior extensor retinaculum (IER). Patients were divided into two groups according to their BMI: ≥ 30 (Group A; n = 26) and < 30 (Group B; n = 43). Patients were pre‐and post‐operatively evaluated, with a minimum of 2 years follow‐up, and using the Karlsson Score. Characteristics of the patients, complications, ankle instability symptoms recurrence, and satisfaction score were recorded.ResultsIn group A, the median Karlsson Score increased from 43.5 (Range 22–72) to 85 (Range 37–100) at follow‐up. Complications were observed in seven patients (27%). Nineteen patients (73%) reported that they were “very satisfied”. One patient (4%) described persistent ankle instability symptoms. In group B, the median Karlsson Score increased from 65 (Range 42–80) to 95 (Range 50–100) at follow‐up. Complications were observed in four patients (9%). Thirty‐three patients (77%) reported that they were “very satisfied”. Two patients (5%) described persistent ankle instability symptoms. Pre‐operative and at last follow‐up Karlsson Score, results were significantly different between the two groups. There was no significant statistical difference in favour of satisfaction score, complications and recurrence of ankle instability between the two groups.ConclusionATFL repair with biological augmentation using IER gives excellent results for patients with BMI ≥ 30. Compared to patients with BMI < 30, they present a slightly lower preoperative and postoperative Karlsson score, however, with a similar satisfaction rate, but are at higher risk of transient superficial peroneal nerve dysesthesia.Level of evidenceLevel III.
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
Authors: Zeitlmayr Sarah , Cami Ditila , Selmani Belinda , Gudermann Thomas , Breit Andreas 
Published: September 2023

AbstractOccupational and environmental exposure of various toxins or cigarette smoke causes non-small cell lung carcinoma (NSCLC); a devastating disease with a very low survival rate after metastasis. Increased activity of plasmin is a hallmark in NSCLC metastasis. It is accepted that metastatic cells exhibit higher plasmin activity than cells from primary tumors. Mechanisms behind this elevation, however, are barely understood. We compared plasmin activity and cell migration of A549 cells derived from a primary lung tumor with metastatic H1299 lung cells isolated from lymph nodes. Surprisingly, we found higher plasmin activity and migration for A549 cells. mRNA levels of the plasminogen activator inhibitor-1 (PAI-1) were higher in H1299 cells and activity of extracellular-regulated kinases-1/2 (ERK-1/2) was increased. An inhibitor of ERK-1/2 decreased PAI-1 mRNA levels and increased plasmin activity or cell migration in H1299 cells. Transforming growth factor-β (TGF-β) decreased plasmin activity and migration in A549 cells but enhanced both in H1299 cells. The cytokine massively increased PAI-1 and decreased urokinase plasminogen activator (uPA) levels in A549 cells but strongly induced uPA and only weakly PAI- 1 expression in H1299 cells. Consequently, TGF-β enhanced plasmin activity and cell migration in H1299. Additionally, TGF-β activated ERK-1/2 stronger in H1299 than in A549 cells. Accordingly, an ERK-1/2 inhibitor completely reversed the effects of TGF-β on uPA expression, plasmin activity and migration in H1299 cells. Hence, we provide first data indicating TGF-β-promoted increased plasmin activity and suggest that blocking TGF-β-promoted ERK-1/2 activity might be a straightforward approach to inhibit NSCLC metastasis.
Neck Reoperation for Recurrent or Persistent Renal Hyperparathyroidism
Authors: Chang Lu‐Chia , Liu Shiuh‐Inn , Liang Tsung‐Jung 
Published: September 2023

AbstractBackgroundPatients with renal hyperparathyroidism undergoing parathyroidectomy may experience relapse. Reoperation for persistent or recurrent disease, particularly in the neck region, is challenging and has a high complication rate because of difficult exploration. We aimed to evaluate the effectiveness of neck reoperation in renal hyperparathyroidism.MethodsPatients with recurrent or persistent renal hyperparathyroidism who underwent neck reoperation between January 2015 and August 2022 were investigated, focusing on operative findings, perioperative biochemical changes, and significance of intraoperative parathyroid hormone (PTH) measurements.ResultsDuring reoperation, 35 parathyroid glands were identified and removed from the 26 enrolled patients, with one, two, and three glands retrieved from 19 (73.2%), five (19.2%), and two (7.6%) patients, respectively. Most removed glands (68.6%) were located in the lower neck, followed by the mediastinum, carotid sheath, and upper neck. Successful resection, defined as a postoperative PTH level of <300 pg/mL, was achieved in 21 patients (80.8%). The remaining four (15.4%) and one (3.9%) patients were classified as having persistent and recurrent disease, respectively. The extent of PTH reduction was correlated with specimen weight, specimen volume, and preoperative alkaline phosphatase (ALP) level. The mean intraoperative PTH ratio (10 min after excision/pre‐excision) was 0.23, and all patients with persistent or recurrent disease had a PTH ratio >0.3. Severe hypocalcemia (<7.5 mg/dL) occurred in 19 (73.0%) patients after reoperation.ConclusionsNeck reoperation is an effective therapeutic option in patients with recurrent or persistent renal hyperparathyroidism. A decrease in PTH level by >70% during reoperation (PTH ratio <0.3) predicts successful resection.
Snack quality and snack timing are associated with cardiometabolic blood markers: the ZOE PREDICT study
Authors: Bermingham Kate M. , May Anna , Asnicar Francesco , Capdevila Joan , Leeming Emily R. , Franks Paul W. , Valdes Ana M. , Wolf Jonathan , Hadjigeorgiou George , Delahanty Linda M. , Segata Nicola , Spector Tim D. , Berry Sarah E. 
Published: September 2023

Abstract
Background
Snacking is a common diet behaviour which accounts for a large proportion of daily energy intake, making it a key determinant of diet quality. However, the relationship between snacking frequency, quality and timing with cardiometabolic health remains unclear.

Design
Demography, diet, health (fasting and postprandial cardiometabolic blood and anthropometrics markers) and stool metagenomics data were assessed in the UK PREDICT 1 cohort (N = 1002) (NCT03479866). Snacks (foods or drinks consumed between main meals) were self-reported (weighed records) across 2–4 days. Average snacking frequency and quality [snack diet index (SDI)] were determined (N = 854 after exclusions). Associations between snacking frequency, quality and timing with cardiometabolic blood and anthropometric markers were assessed using regression models (adjusted for age, sex, BMI, education, physical activity level and main meal quality).

Results
Participants were aged (mean, SD) 46.1 ± 11.9 years, had a mean BMI of 25.6 ± 4.88 kg/m2 and were predominantly female (73%). 95% of participants were snackers (≥ 1 snack/day; n = 813); mean daily snack intake was 2.28 snacks/day (24 ± 16% of daily calories; 203 ± 170 kcal); and 44% of participants were discordant for meal and snack quality. In snackers, overall snacking frequency and quantity of snack energy were not associated with cardiometabolic risk markers. However, lower snack quality (SDI range 1–11) was associated with higher blood markers, including elevated fasting triglycerides (TG (mmol/L) β; – 0.02, P = 0.02), postprandial TGs (6hiAUC (mmol/L.s); β; – 400, P = 0.01), fasting insulin (mIU/L) (β; – 0.15, P = 0.04), insulin resistance (HOMA-IR; β; – 0.04, P = 0.04) and hunger (scale 0–100) (β; – 0.52, P = 0.02) (P values non-significant after multiple testing adjustments). Late-evening snacking (≥ 9 pm; 31%) was associated with lower blood markers (HbA1c; 5.54 ± 0.42% vs 5.46 ± 0.28%, glucose 2hiAUC; 8212 ± 5559 vs 7321 ± 4928 mmol/L.s, P = 0.01 and TG 6hiAUC; 11,638 ± 8166 vs 9781 ± 6997 mmol/L.s, P = 0.01) compared to all other snacking times (HbA1c remained significant after multiple testing).

Conclusion
Snack quality and timing of consumption are simple diet features which may be targeted to improve diet quality, with potential health benefits.

Clinical trial registry number and website
NCT03479866, https://clinicaltrials.gov/ct2/show/NCT03479866?term=NCT03479866&draw=2&rank=1
Human protozoa infection and dysplasia in ulcerative colitis: a neglected aspect in a prominent disease
Authors: Abdel Hamed Enas F. , Mostafa Nahed E. , Farag Shaimaa M. , Ibrahim Mohamed N. , Ibrahim Basma H. , Rashed Hayam E. , Radwan Mona , Mohamed Salem Y. , El Hendawy Ramy , Fawzy Eman M. 
Published: September 2023

AbstractThe chance of getting colorectal cancer (CRC) is higher in people with chronic ulcerative colitis (UC). The impact of parasitic infections on UC is underappreciated. The purpose of this study was to look into the effect of intestinal protozoal infections on the dysplastic changes generated by UC. The research included 152 adult patients with histologically confirmed UC and 152 healthy controls. Fecal samples were examined for the presence of parasites and fecal calprotectin (FC). The enzyme-linked immunosorbent assay measured serum anti-p53 antibodies (p53Abs) and metallothioneins (MTs). The advanced oxidation protein products (AOPPs) and reduced glutathione (GSH) levels were measured by a spectrophotometric method in all subjects. Serum C-reactive protein (CRP) and IL-6 were also measured. In addition, histopathological and immunohistochemical investigations of intestinal tissue were done. Our results exhibited significant increases in FC and CRP, IL-6, AOPPs, MTs, and p53Abs in ulcerative colitis patients with parasitic infections compared to those without parasites. In contrast, GSH levels showed a significant decrease in the same group compared with other groups. Histopathological and immunohistochemical assessments of intestinal tissue signified severe inflammation and strong expression of PD-L1 in patients with parasitic infections compared to others without parasitic infections. Our research indicated a greater frequency of intestinal protozoa in UC patients with elevated inflammatory and dysplastic biomarker levels. This suggests that these parasites may be involved in the etiology of chronic UC and the associated carcinogenetic process. This is the first report of a link between parasitic infections and dysplastic alterations in UC patients.