bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape of four different stages of human gastric cancer revealed by single-cell sequencing
Authors: Tang Xu-Shan , Xu Chun-Lei , Li Na , Zhang Jian-Qing , Tang Yong 
Published: January 2025

BACKGROUND
Gastric cancer (GC) poses a substantial risk to human health due to its high prevalence and mortality rates. Nevertheless, current therapeutic strategies remain insufficient. Single-cell RNA sequencing (scRNA-seq) offers the potential to provide comprehensive insights into GC pathogenesis.
AIM
To explore the distribution and dynamic changes of cell populations in the GC tumor microenvironment using scRNA-seq techniques.
METHODS
Cancerous tissues and paracancerous tissues were obtained from patients diagnosed with GC at various stages (I, II, III, and IV). Single-cell suspensions were prepared and analyzed using scRNA-seq to examine transcriptome profiles and cell-cell interactions. Additionally, quantitative real-time polymerase chain reaction (qRT-PCR) and flow cytometry were applied for measuring the expression of cluster of differentiation (CD) 2, CD3D, CD3E, cytokeratin 19, cytokeratin 8, and epithelial cell adhesion molecules.
RESULTS
Transcriptome data from 73645 single cells across eight tissues of four patients were categorized into 25 distinct cell clusters, representing 10 different cell types. Variations were observed in these cell type distribution. The adjacent epithelial cells in stages II and III exhibited a degenerative trend. Additionally, the quantity of CD4 T cells and CD8 T cells were evidently elevated in cancerous tissues. Interaction analysis displayed a remarkable increase in interaction between B cells and other mast cells in stages II, III, and IV of GC. These findings were further validated through qRT-PCR and flow cytometry, demonstrating elevated T cells and declined epithelial cells within the cancerous tissues.
CONCLUSION
This study provides a comprehensive analysis of cell dynamics across GC stages, highlighting key interactions within the tumor microenvironment. These findings offer valuable insights for developing novel therapeutic strategies.
Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer
Authors: Wang Long , Wu Qi , Zhang Zong-Wen , Zhang Hui , Jin Hui , Zhou Xin-Liang , Liu Jia-Yin , Li Dan , Liu Yan , Fan Zhi-Song 
Published: January 2025

BACKGROUND
Colony-stimulating factor 3 (CSF3) and its receptor (CSF3R) are known to promote gastric cancer (GC) growth and metastasis. However, their effects on the immune microenvironment remain unclear. Our analysis indicated a potential link between CSF3R expression and the immunosuppressive receptor leukocyte immunoglobulin-like receptor B2 (LILRB2) in GC. We hypothesized that CSF3/CSF3R may regulate LILRB2 and its ligands, angiopoietin-like protein 2 (ANGPTL2) and human leukocyte antigen-G (HLA-G), contributing to immunosuppression.
AIM
To investigate the relationship between CSF3/CSF3R and LILRB2, as well as its ligands ANGPTL2 and HLA-G, in GC.
METHODS
Transcriptome sequencing data from The Cancer Genome Atlas were analyzed, stratifying patients by CSF3R expression. Differentially expressed genes and immune checkpoints were evaluated. Immunohistochemistry (IHC) was performed on GC tissues. Correlation analyses of CSF3R, LILRB2, ANGPTL2, and HLA-G were conducted using The Cancer Genome Atlas data and IHC results. GC cells were treated with CSF3, and expression levels of LILRB2, ANGPTL2, and HLA-G were measured by quantitative reverse transcriptase-polymerase chain reaction and western blotting.
RESULTS
Among 122 upregulated genes in high CSF3R expression groups, LILRB2 showed the most significant increase. IHC results indicated high expression of LILRB2 (63.0%), ANGPTL2 (56.5%), and HLA-G (73.9%) in GC tissues. Strong positive correlations existed between CSF3R and LILRB2, ANGPTL2, and HLA-G mRNA levels (P < 0.001). IHC confirmed positive correlations between CSF3R and LILRB2 (P < 0.001), and HLA-G (P = 0.010), but not ANGPTL2 (P > 0.05). CSF3 increased LILRB2, ANGPTL2, and HLA-G expression in GC cells. Heterogeneous nuclear ribonucleoprotein H1 modulation significantly altered their expression, impacting CSF3’s regulatory effects.
CONCLUSION
The CSF3/CSF3R pathway may contribute to immunosuppression in GC by upregulating LILRB2 and its ligands, with heterogeneous nuclear ribonucleoprotein H1 playing a regulatory role.
The Impact of Training Program Based on Kagan Structures in Improving the Instructional Competencies Among Non-Native Arabic Language Teachers in Jordan
Authors: ALrbihat Lubna Ahmad , Alhaddad Abdelkareem Saleem 
Published: January 2025

Objective: This study aimed to reveal the effectiveness of the training program based on Kagan's structures in improving the teaching competencies of Arabic language teachers for non-native speakers.

Theoretical Framework: Through the work of researchers in the field of teaching Arabic for other speakers, they have noted the weakness of Arabic language teachers for other speakers in teaching skills. This requires the design of a training programme to improve teaching skills among teachers and the inclusion of teachers in the atmosphere of successful teaching. Kagan structures are of great importance. They give teachers confidence in language education and communication with others, including learners, and increase their motivation towards the teaching profession.

Method: The study sample consisted of (30) male and female teachers from the eTurn Institute and the Qased Center for Teaching Arabic to Non-Native Speakers in Amman. The two centers were chosen intentionally and the sample was distributed into two groups: an experimental group consisting of (15) male and female teachers who received training based on Kagan's structures, and a control group consisting of (15) male and female teachers who did not receive training based on Kagan's structures. To achieve the study objectives, the researchers prepared the training program based on Kagan's structures, a trainee's guide, and a list of teaching competencies and indicators indicating them. The scale was applied to the two groups before and after training. The researchers used the quasi-experimental approach to achieve the study objectives.

Results and Discussion: The results of the statistical analysis showed that there were statistically significant differences at the significance level (α=0.05) between the experimental and control groups in the scale of teaching competencies, except for planning competencies, which are attributed to the training program based on Kagan's structures.

Research Implications: The researchers recommended paying attention to improving the competencies of Arabic language teachers for non-native speakers in the field of planning for Arabic language teachers for non-native speakers, and improving the competencies of formative evaluation for Arabic language teachers for non-native speakers

Originality/Value: Arabic has a high place among languages. It is a long-standing language with deep roots, rooted in history. Its sons strive to spread Arabic throughout the world in terms of language learning and teaching. The Arabic language attracts non-speaking learners from all over the world for public or private purposes. Some of them study Arabic for communication, military, or political purposes. Some of them study Arabic for informational and economic purposes. This has raised the importance of teaching Arabic among the world's languages.
Partnerships for Sustainable Development: a Quintuple Helix Framework for Research, Innovation, and Extension in Philippine State Universities
Authors: Armas Kenneth L. , Villegas Marivic N. 
Published: January 2025

Objectives: This study investigates the potential use of the Quintuple Helix Model in strengthening Research, Innovation and Extension (RIE) functions among State Universities and Colleges (SUCs) in the Philippines. It assesses the dynamics between SUCs, the government, industry, and civil society, as well as the natural environment.

Method: This study conducts a systematic review of literature and government reports: data from peer-reviewed journals, policy documents, and publications of various key agencies such as the Commission on Higher Education (CHED), Department of Science and Technology (DOST), and National Economic and Development Authority (NEDA) are analyzed. Patterns, gaps and opportunities based on Quintuple Helix were coded using thematic and content analysis.

Results and Discussion: SUCs are identified as central to knowledge generation and transformation of society, but their potential is dependent on three interlinked factors; inadequate infrastructures, limited funding and fragmented policies. Theoretical collaborations, from technology transfer processes to community engagement efforts, shed light on the potential of partnerships across different sectors manifested as experimental projects, though persistent challenges present as intellectual property troubles or misaligned interests often hinder successful cooperation.

Research Implications: The research highlights the need for coordinated investments in infrastructure, skills and governance reforms. Public-private Partnerships and inter-disciplinary research are then recommended to maximize SUCs contribution to sustainable development.

Originality/Value: This study presents a corroborated discourse on the application of the Quintuple Helix Model in the Philippine context of SUCs, its results can yield practical insights, and scalable strategies to enhance the functions of RIE, thus serving as a valuable reference for policymakers, educators, and researchers.
Dynamics of Interest Rates, Inflation and Forex in ARDL Framework: Evidence from India in an SDG Context
Authors: Yusuf Umar , Gupta Pankaj Kumar 
Published: January 2025

Objective: This study examines the dynamic causal relationship between the exchange rate, inflation, and interest rate from 2011 to 2023.

Method: Using both the linear autoregressive distributed lag (ARDL) and nonlinear ARDL (NARDL) methods, the results show that exchange rate and inflation have an equilibrium relationship over the long term.

Results and Discussion: However, the connection between the interest rate and the exchange rate is unstable. As the inflation rate changes, the exchange rate displays its dynamic behavior. As opposed to this, interest rates shouldn't always affect how currencies behave. Policy ramifications of this study are evident. Price stability can only be attained with accurate fundamentals. Central banks that promote environmental sustainability and align with the United Nations' Sustainable Development Goals (SDGs) frequently use a Sustainability-Linked Monetary Policy (SLMP) framework.

Contributions: This framework targets emission activities through interest rates or loan-to-value ratios, with the goal of influencing liquidity for greener production.

Conclusions: However, the welfare implications of such policies are still unclear (MAS, 2021; LMA, 2019; DBS, 2021; BOJ, 2021; Mizuho, 2021).
Human Emotions Associated with Climate Change at the Salache Campus of the Technical University of Cotopaxi, Ecuador
Authors: Cevallos Manuel Patricio Clavijo , Tito Sofía Katherine Solórzano , Gutiérrez Heimmy Isabel Torres , Mena Carla Elizabeth Vallejo 
Published: January 2025

Objective: This study investigates human emotions associated with climate change among the university community at the Salache Campus of the Technical University of Cotopaxi, Ecuador, aiming to understand perceptions and responses to climate challenges in an academic environment, complying with SDG 3 on Health and well-being and SDG 11 related to Sustainable cities and communities.

Theoretical Framework: The research is grounded in environmental psychology and climate change impact theories, focusing on key concepts such as eco-anxiety and solastalgia, while examining psychological responses to environmental changes across different demographic groups.

Method: The study employs systematic observation and assessment of psychological responses to environmental changes, focusing on the university community's reactions to extreme weather events and climate-related transformations in their environment.

Results and Discussion: Results revealed significant emotional impacts of climate change on the university community, particularly in relation to Ecuador's documented 40% glacier loss. These findings show manifestations such as anxiety, panic attacks, and sleep disturbances in response to environmental changes.

Research Implications: The findings provide insights for improving climate change education and psychological support systems in academic institutions, with implications for educational policy and mental health services.

Originality/Value: This study uniquely examines psychological impacts of climate change in an Ecuadorian academic context, offering new perspectives on how university communities process environmental challenges, while informing institutional responses to climate-related psychological stress.
Strategi Komunikasi Indonesia Memperkuat Posisi sebagai Pusat Gaya Busana Muslim Global
Authors: Yusuf Ramayani , Haerani Hanni , Yulianita Neni 
Published: January 2025

Indonesia telah lama dikenal sebagai salah satu pusat mode busana muslim dunia. , Indonesia memiliki potensi besar untuk memperkuat posisinya sebagai kiblat global dalam industri busana muslim. Penelitian ini menganalisis strategi komunikasi yang dapat diterapkan Indonesia untuk memperkuat posisinya sebagai pusat gaya busana muslim global. Menggunakan pendekatan kualitatif, penelitian dilakukan melalui studi literatur, wawancara mendalam dengan pemangku kepentingan industri busana muslim, dan analisis kebijakan pengembangan industri kreatif.. Hasil penelitian mengidentifikasi lima strategi komunikasi utama: (1) pengembangan narasi "Indonesia sebagai Kiblat Busana muslim Dunia" melalui diplomasi budaya dan fashion; (2)penguatan kolaborasi antara pemerintah, desainer, dan pelaku industri; (3) optimalisasi platform digital (4)penyelenggaraan event busana muslim internasional; (5) pemberdayaan UMKM busana muslim melalui pelatihan dan akses pasar global. Penelitian ini memberikan kerangka strategis bagi pengembangan industri busana muslim Indonesia dan penguatan posisinya dalam peta busana muslim global. Implementasi strategi komunikasi yang terencana dan terkoordinasi akan mendukung tercapainya visi Indonesia.
Peran Kepemimpinan Dalam Membangun Mengembangkan Manajemen Sumber Daya Manusia Di Sekolah
Authors: Mahsunah Mahsunah , Ayuni Aditya Putra , Hidayat Andyni Loisalina , UlulAzmi Arida 
Published: January 2025

This research discusses the role of leadership in the development and management of human resources (HR) in schools. Human resources are an important element that determines the effectiveness and productivity of an educational institution. This research aims to explore the role of leaders in managing human resources, especially regarding the challenges faced, the leadership strategies implemented, and their impact on improving the quality of teaching staff. The research method applied is literature study, by collecting information from a variety of relevant sources, such as books, journals and previous research. The research results show that quality leadership plays a significant role in creating a productive work environment, increasing the motivation of teaching staff, and optimizing the use of school resources. The conclusions of this research emphasize the importance of an adaptive and empowering leadership style to improve the overall performance of educational institutions.
TEXNIK VA SANʼAT FANLARINI INTEGRATIV OʻQITISHDA SINERGETIK KOMPETENTLIKNI TAKOMILLASHTIRISH
Authors: Haqberdiyev Baxtiyor 
Published: January 2025

Ushbu maqolada texnik va sanʼat fanlarini integrativ yondashuvlar, sinergetik yondashuvlar va kompetentlikni takomillashtirish boʻyicha yurtimiz va xorij olimlari tomonidan qilingan ilmiy izlanishlari, bu ikki fan tarkibidagi fanlarni integratsiyalash mutaxassislik talabalarida qiziqarli boʻlishi, mavzular kengayishi, yanada chuqurroq tushunib yetishlari va hayotiy faoliyatlarida muhim rol oʻynashi, texnik va sanʼat fanlarini sinergetik kompetentlikni, yondashuvlarni integrativ oʻqitish orqali oʻzini-oʻzi rivojlantiruvchi, toʻldiruvchi, yetaklovchi, hamkorlik qiluvchi, axborotlar almashinuvchi, bilim, koʻnikma va malakalarga ega boʻluvchi, muhandislik grafikasi fanlaridagi mos keluvchi mavzularni modellashtirish, aloqadorligini qay holatda taʼsirini tahlil qilish, vizualizatsiyalashtirish va optimallashtirishda yordam berishi haqida qisqacha yoritib berilgan.
XALQ TAʼLIMI PEDAGOGLARNI MALAKASINI OSHIRISH JARAYONIDA HUQUQIY ONG VA HUQUQIY MADANIYATINI YUKSALTIRISHGA OID XORIJ TAJRIBASI
Authors: Boymirzayeva Raximaxon 
Published: January 2025

Ushbu maqolada, xalq ta’limi tizimida faoliyat olib boruvchi pedagog kadrlarni malaka oshirish jarayonida huquqiy ongini rivojlantirish va huquqiy madaniyatlarini yuksaltirishda xorij tajribasi va uning ayrim xususiyatlariga qaratilgan masalalar tahlil etilgan. Malaka oshirish jarayonida tinglovchilarning huquqiy madaniyatini yuksaltirishda malaka oshirish ta’lim muassasalarida horijiy tajribalarni qo`llash orqali, maktab o`qituvchilarini malaka oshirish jarayonidagi huquqiy ong va huquqiy madaniyatlarini oshirishga oid horijiy metodlarni dars jarayoniga joriy qilishga doir tavsiyalar berilgan. Malaka oshirish jarayonida tinglovchining huquqiy madaniyatini yuksaltirishga oid xulosalar berilgan.
NUTQIY MADANIYATNI O‘STIRISHNING NAZARIY VA AMALIY ASOSLARI
Authors: Umirova Mamlakat 
Published: January 2025

Mazkur maqolada ona tili darslarida oʻquvchilarning ogʻzaki va yozma nutqini rivojlantirish haqida fikr yuritilgan. Til imkoniyatlaridan nutqiy muloqotda foydalanish koʻnikmasini shakllantirishga qaratilgan topshiriqlar ishlab chiqilgan. Soʻzlarning izohi va ularning maʼnoviy guruhlarini lingvistik ongda aks ettirish usullari haqida maʼlumot berilgan.
Peran Gaya Kepemimpinan Kepala Sekolah dan Motivasi Kerja terhadap Kinerja Guru Sekolah Dasar Negeri Balongsari di Kota Mojokerto
Authors: Sudarnice  , Yulia Mayang Saputri  
Published: January 2025

Penilaian kinerja guru pada Sekolah Dasar Negeri (SDN) Balongsari se-Kota Mojokerto menggunakan Rubrik observasi kinerja guru Penerapan disiplin Positif (RPP) pada bulan Januari – Juni 2024, diketahui terdapat tiga guru memiliki nilai rata-rata dibawah kriteria ketuntasan minimal 70 yang masing-masing memiliki nilai 63.3; 33.3; dan 60 yang mengartikan kinerja guru belum optimal. Berdasarkan permasalahan tersebut, dilakukan analisis bertujuan mengetahui bagaimana pengaruh gaya kepemimpinan kepala sekolah dan motivasi kerja terhadap kinerja guru SDN Balongsari Se-Kota Mojokerto. Penelitian menggunakan metode kuantitatif dan analisis regresi linear dengan 3 variabel, yakni Gaya Kepemimpinan Kepala Sekolah (X1), Motivasi Kerja (X2), dan Kinerja Guru (Y). Sampel penelitian yakni 30 responden guru SDN Balongsari se-Kota Mojokerto dengan proses pengumpulan data menggunakan teknik kuesioner yang disebar menggunakan Google Form dan pengolahan data menggunakan Aplikasi SmartPLS. Hasil penelitian menunjukkan gaya kepemimpinan kepala sekolah tidak berpengaruh signifikan terhadap kinerja guru dengan nilai p values 0178 dan T-Statistic 0.923, dan motivasi kerja tidak berpengaruh signifikan terhadap kinerja guru dengan nilai p values 0.102 dan T-Statistic 1.273
Penggunaan Aplikasi Geogebra terhadap Materi Integral pada Mahasiswa Semester II Program Studi Pendidikan Matematika Universitas Lelemuku Saumlaki
Authors: Ratuanik Mesak , Ranguly Alex , Bacori Zakarias , Watratan Yoseph 
Published: January 2025

Materi integral merupakan salah satu dari dua materi besar di mata kuliah kalkulus, yang mana materi integral merupakan anti turunan dari materi diferensial. Integral dikembangkan untuk menjawab pertanyaan bagaimana menyelesaikan masalah yang berkebalikan dengan solusi diferensial. penggunaan media digital dalam pembelajaran matematika di perguruan tinggi merupakan solusi yang tepat untuk memecahkan matematika abstrak diantaranya materi integral. Dengan demikian penggunaan aplikasi geogebra merupakan solusi yang tepat dalam proses perkuliahan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif karena peneliti ingin menggambarkan dan menguraikan secara rinci dan mendalam tentang penggunaan aplikasi geogebra terhadap materi integral dalam proses perkuliahan di semester II Program Studi Pendidikan Matematika. Jenis pengumpulan data yang dilakukan dalam penelitian ini adalah Observasi, Wawancara, Dokumentasi, tes, catatan lapangan dan studi pustaka. Hasil penelitian menunjukan bahwa dengan menggunakan aplikasi geogebra mahasiswa dapat menyelesaikan materi integral tentu serta Efektifitas dan motivasi mahasiswa terhadap pembelajaran yang memanfaatkan teknologi.
Immunological effectiveness of the booster Soberana Plus vaccine (FINLAY-FR-1A)
Authors: Korsak K. S. , Voropaev E. V. , Osipkina O. V. , Kovalev A. A. , Stoma I. O. 
Published: January 2025

Objective. To assess the efficacy of immunogenicity of the Soberana Plus (FINLAY-FR-1A) vaccine in adults previously vaccinated against COVID-19.Materials and methods. A total of 98 participants participated in the study. The immunogenicity of the Soberana Plus (FINLAY-FR-1A) vaccine was studied by measuring IgG concentration to SARS-CoV-2 by enzyme-linked immunosorbent assay (ELISA) at 4 study sites: day 0, in 42 days, 90 days and 180 days after the Soberana Plus (FINLAY-FR-1A) administration.Results. Participants of the study were divided into groups based on their primary immunization: 1) Sputnik V (Gam-COVID-Vac) / Sputnik Light; 2) Sinopharm (BBIBP-CorV); 3) Sinopharm (BBIBP-CorV) + Sputnik V (Gam-COVIDVac) / Sputnik Light. The highest IgG level was observed in 90 days after administration of booster dose (p< 0,001). At the “90 day” point, IgG levels were higher in the previously vaccinated with Sputnik V (Gam-COVID-Vac) / Sputnik Light + Sinopharm (BBIBP-CorV), however, this group had higher IgG levels before the Soberana Plus (FINLAY-FR-1A) administration. In 42 days after vaccination, participants of the age group “45 plus” had the highest IgG level, and in 180 days participants of the age group “45 plus” had the highest IgG level compared to the age group “25-45 years old” (р=0,048).Conclusion. Soberana Plus (FINLAY-FR-1A) vaccine is quite immunogenic. The highest level of IgG to SARS-CoV-2 marked on day 90 (р
Ultrasound elastography: possibilities for early diagnosing in case of sciatic nerve mononeuropathy
Authors: Pismennikova E. I. , Yurkovskiy А. М. , Bobovich N. V. , Likhachevskaya M. А. 
Published: January 2025

Objective. To evaluate the possibility of using ultrasound elastography to detect early manifestations of sciatic nerve mononeuropathy.Materials and methods. A comparison of ultrasound elastography data of the sciatic nerve of 30 patients aged 46.0 (23; 54) years with clinical manifestations of sciatic nerve mononeuropathy (experimental group) and 30 patients aged 36.5 (29; 48) years without lower back pain back (control group) was made to achieve this goal.Results. Assessment results of the diagnostic utility of ultrasound elastography as a method for diagnosing mononeuropathy of the sciatic nerve were as follows (with an asymmetry between the stiffness indices of comparable segments of the symptomatic and asymptomatic sides of more than 22%): AUC - 0,88 (95% CI (0,55; 0,99)), р=0,003; Youden index - 0.87, sensitivity - 87% (95% CI (0,5; 0,99)), р=0,0001; 100% (95% CI (0,5; 0,99)), р=0,0001.Conclusion. Ultrasound elastography makes it possible to detect changes in the structure of the sciatic nerve in cases where a standard B-mode study does not reveal changes. The presence of clinical signs suggesting mononeuropathy of the sciatic nerve, in the absence of structural changes in the B-mode, should be considered the basis for performing ultrasound elastography in order to detect perineural and intraneural edema, as well as structural changes in the sciatic nerve.