bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trend of blood donors entering the coronavirus pandemic era and challenges: Age‐period‐cohort analysis using 75.5 million all blood donations data during 2006–2020 in Japan
Authors: Imada Hirohito , Akita Tomoyuki , Sugiyama Aya , Tanaka Junko 
Published: May 2023

AbstractBackgroundIn Japan, “Blood Donation Promotion 2025,” a blood donation target, was established based on a predicted blood donation rate of 5.7% in 2025, which was calculated by the Blood Donation Promotion Study Group (BD research group) of the Ministry of Health, Labor and Welfare using nationwide blood donation data through 2018. However, COVID‐19 since 2020 may affect the blood donation rate in Japan.MethodData from 75.5 million blood donations from 2006 to 2020 was used. The age‐period‐cohort model (APC model) was applied to estimate age, period, and birth cohort factors on blood donation rate and to predict the age‐specific blood donation rates from 2021 to 2035.ResultsThe APC model was highly reproducible for blood donation rates (modified R2 = 0.99). The blood donation rate in 2020 was 6.0% (5.04 million), an increase compared to 2019. Comparing this study with the BD research group, the predicted blood donation rates in 2025 for those 16–19 years old and in 20s are lower (4.8% vs. 5.2% and 5.3% vs. 5.5%) but those among 50s and 60s are higher (7.9% vs. 7.5% and 4.2% vs. 3.9%, respectively).DiscussionThe number of blood donations in 2020 increased despite COVID‐19 and it proved that the blood donation promotion was effective. The different age‐specific blood donation rates between our study and the report of BD research group infers the effect of COVID‐19 on blood donation were differed by age and suggested the need for different approaches to blood donation promotion by generation.
A remote fluorescein staining and photography protocol for monitoring of ulcerative keratitis in small animal patients: A pilot study
Authors: Li Puma Margaret C. , Diehl Kathryn A. , Myrna Kathern E. 
Published: May 2023

AbstractObjectiveTo describe a protocol for corneal ulcer monitoring utilizing daily fluorescein staining and evaluation of owner‐acquired anterior segment images.Animal studiedNine client‐owned small animal patients (eight dogs, one cat) diagnosed with superficial corneal ulcers at the University of Georgia Veterinary Hospital.Procedure(s)In addition to routine ulcer therapy, patients were discharged with supplies to perform daily fluorescein staining including a Quikvue® cobalt blue light camera adapter. Fluorescein staining was performed daily, photographs and/or videos were acquired at home by the patient's owner(s), and images were analyzed daily by trained personnel. In‐house examinations were performed weekly and within 24 h after the ulcer had appeared healed on photographs.ResultsAll (9/9) owners were able to take interpretable photographs. The majority (6/9) of patients had images successfully detailing their ulcer healing progress. One (1/9) patient appeared healed on images, but on subsequent examination had persistent ulceration covered by third eyelid elevation. Two (2/9) patients had persistent ulceration, consistent on both images and examination, but exited the study prematurely prior to ulcer healing.ConclusionsRemote fluorescein staining and image evaluation can be considered as an adjunct for monitoring ulcer healing but should not be used alone or as a substitute for ophthalmic examinations. Ulcers under the third eyelid have potential to be missed on image evaluation alone.
Physiological and Energetic Demands During Still-Rings Routines of Elite Artistic Gymnasts
Authors: Seemann-Sinn Alexander , Rüdrich Peter , Gorges Tom , Naundorf Falk , Wolfarth Bernd 
Published: May 2023

Purpose: The aim of the study was to analyze physiological and energetic demands of elite gymnasts during still-rings routines (SRRs). Methods: Eleven male gymnasts (mean [SD] 23.6 [3.9] y, 65.9 [5.6] kg, 171.1 [6.7] cm) performed a maximal graded exercise test and an individual SRR, during which respiratory gas and heart rate (HR) were measured using a mobile spiroergometer and a paired HR sensor. Metabolic energy and the energy contribution in terms of aerobic, anaerobic lactic, and anaerobic alactic were determined by oxygen uptake (VO2) during exercise, net lactate production, and the fast component of postexercise VO2 kinetics. Results: Mean routine duration of the SRRs was 48.3 (4.5) seconds. VO2 and HR during SRRs were shown to be 86.9% (5.9%) and 91.0% (3.3%), respectively, of the maximal values measured during the graded exercise test. The anaerobic alactic, aerobic, and anaerobic lactic systems provided 50.9% (6.6%), 28.6% (4.8%), and 20.5% (5.2%), respectively, of the total energy required during SRRs. The energy contribution of the anaerobic lactic system correlated negatively with individual anaerobic threshold (r = −.715) and maximal VO2 (r = −.682). Conclusions: The anaerobic alactic system is the predominant energy source for ATP resynthesis during SRRs. The high relative VO2 and HR values reached during SRRs show that these routines strongly stress the cardiovascular system.
Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial
Authors: Gögenur Mikail , Balsevicius Lukas , Bulut Mustafa , Colak Nesibe , Justesen Tobias Freyberg , Fiehn Anne-Marie Kanstrup , Jensen Marianne Bøgevang , Høst-Rasmussen Kathrine , Cappelen Britt , Gaggar Shruti , Tajik Asma , Zahid Jawad Ahmad , Bennedsen Astrid Louise Bjørn , D’Ondes Tommaso Del Buono , Raskov Hans , Sækmose Susanne Gjørup , Hansen Lasse Bremholm , Salanti Ali , Brix Susanne , Gögenur Ismail 
Published: May 2023

BackgroundIn colorectal cancer, the effects of immune checkpoint inhibitors are mostly limited to patients with deficient mismatch repair tumors, characterized by a high grade infiltration of CD8+T cells. Interventions aimed at increasing intratumoral CD8+T-cell infiltration in proficient mismatch repair tumors are lacking.MethodsWe conducted a proof of concept phase 1/2 clinical trial, where patients with non-metastasizing sigmoid or rectal cancer, scheduled for curative intended surgery, were treated with an endoscopic intratumorally administered neoadjuvant influenza vaccine. Blood and tumor samples were collected before the injection and at the time of surgery. The primary outcome was safety of the intervention. Evaluation of pathological tumor regression grade, immunohistochemistry, flow cytometry of blood, tissue bulk transcriptional analyses, and spatial protein profiling of tumor regions were all secondary outcomes.ResultsA total of 10 patients were included in the trial. Median patient age was 70 years (range 54–78), with 30% women. All patients had proficient mismatch repair Union of International Cancer Control stage I–III tumors. No endoscopic safety events occurred, with all patients undergoing curative surgery as scheduled (median 9 days after intervention). Increased CD8+T-cell tumor infiltration was evident after vaccination (median 73 vs 315 cells/mm2, p<0.05), along with significant downregulation of messenger RNA gene expression related to neutrophils and upregulation of transcripts encoding cytotoxic functions. Spatial protein analysis showed significant local upregulation of programmed death-ligand 1 (PD-L1) (adjusted p value<0.05) and downregulation of FOXP3 (adjusted p value<0.05).ConclusionsNeoadjuvant intratumoral influenza vaccine treatment in this cohort was demonstrated to be safe and feasible, and to induce CD8+T-cell infiltration and upregulation of PD-L1 proficient mismatch repair sigmoid and rectal tumors. Definitive conclusions regarding safety and efficacy can only be made in larger cohorts.Trial registration numberNCT04591379.
Radon and lung cancer in the pooled uranium miners analysis (PUMA): highly exposed early miners and all miners
Authors: Kelly-Reif Kaitlin , Bertke Stephen J , Rage Estelle , Demers Paul A , Fenske Nora , Deffner Veronika , Kreuzer Michaela , Samet Jonathan , Schubauer-Berigan Mary K , Tomasek Ladislav , Zablotska Lydia B , Wiggins Charles , Laurier Dominique , Richardson David B 
Published: May 2023

ObjectivesRadon is a ubiquitous occupational and environmental lung carcinogen. We aim to quantify the association between radon progeny and lung cancer mortality in the largest and most up-to-date pooled study of uranium miners.MethodsThe pooled uranium miners analysis combines 7 cohorts of male uranium miners with 7754 lung cancer deaths and 4.3 million person-years of follow-up. Vital status and lung cancer deaths were ascertained between 1946 and 2014. The association between cumulative radon exposure in working level months (WLM) and lung cancer was modelled as the excess relative rate (ERR) per 100 WLM using Poisson regression; variation in the association by temporal and exposure factors was examined. We also examined analyses restricted to miners first hired before 1960 and with <100 WLM cumulative exposure.ResultsIn a model that allows for variation by attained age, time since exposure and annual exposure rate, the ERR/100 WLM was 4.68 (95% CI 2.88 to 6.96) among miners who were less than 55 years of age and were exposed in the prior 5 to <15 years at annual exposure rates of <0.5 WL. This association decreased with older attained age, longer time since exposure and higher annual exposure rate. In analyses restricted to men first hired before 1960, we observed similar patterns of association but a slightly lower estimate of the ERR/100 WLM.ConclusionsThis new large, pooled study confirms and supports a linear exposure–response relationship between cumulative radon exposure and lung cancer mortality which is jointly modified by temporal and exposure factors.
Methotrexate treatment in early psoriatic arthritis in comparison to rheumatoid arthritis: an observational nationwide study
Authors: Lindström Ulf , di Giuseppe Daniela , Exarchou Sofia , Alenius Gerd-Marie , Olofsson Tor , Klingberg Eva , Jacobsson Lennart , Askling Johan , Wallman Johan K 
Published: May 2023

IntroductionWe aimed to compare the proportions of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) remaining on methotrexate (regardless of other disease-modifying antirheumatic drug (DMARD)-changes), and proportions not having started another DMARD (regardless of methotrexate discontinuation), within 2 years of starting methotrexate, as well as methotrexate effectiveness.MethodsPatients with DMARD-naïve, newly diagnosed PsA, starting methotrexate 2011–2019, were identified from high-quality national Swedish registers and matched 1:1 to comparable patients with RA. Proportions remaining on methotrexate and not starting another DMARD were calculated. For patients with disease activity data at baseline and 6 months, response to methotrexate monotherapy was compared through logistic regression, applying non-responder imputation.ResultsIn total, 3642/3642 patients with PsA/RA were included. Baseline patient-reported pain and global health were similar, whereas patients with RA had higher 28-joint scores and evaluator-assessed disease activity. Two years after methotrexate start, 71% of PsA vs 76% of patients with RA remained on methotrexate, 66% vs 60% had not started any other DMARD, and 77% vs 74% had not started specifically a biological or targeted synthetic DMARD. At 6 months, the proportions of patients with PsA versus RA achieving pain-scores ≤15 mm were 26% vs 36%; global health ≤20 mm: 32% vs 42%; evaluator-assessed ‘remission’: 20% vs 27%, with corresponding adjusted ORs (PsA vs RA) of 0.63 (95% CI 0.47 to 0.85); 0.57 (95% CI 0.42 to 0.76) and 0.54 (95% CI 0.39 to 0.75).DiscussionIn Swedish clinical practice, methotrexate use is similar in PsA and RA, both regarding initiation of other DMARDs and methotrexate retention. On a group level, disease activity improved during methotrexate monotherapy in both diseases, although more so in RA.
A Taxonomy and Analysis of Misbehaviour Detection in Cooperative Intelligent Transport Systems: A Systematic Review
Authors: Amanullah Mohamed Ahzam , Loke Seng W. , Baruwal Chhetri Mohan , Doss Robin 
Published: May 2023

Cooperative Intelligent Transport Systems (C-ITS) is one of the proposed solutions to improve the safety and efficiency of road transport. However, C-ITS is prone to misbehaviours that can cause devastating effects such as road accidents and potential loss of life. While there are several research studies including technical studies and surveys that discuss misbehaviour detection in C-ITS, they tend to focus on specific aspects of misbehaviour detection and do not provide a comprehensive and unified coverage. With the objective of serving as a reference for future researchers, this study provides a comprehensive survey of misbehaviour detection in C-ITS. It identifies and discusses the key causes of misbehaviour in C-ITS, and the mechanisms used to detect them. Additionally, it proposes a thematic taxonomy on misbehaviour detection based on a comparative analysis of the technical studies. Furthermore, the existing solutions from the state-of-the-art and their shortcomings are also presented. Finally, this study highlights several significant research challenges and discusses future research directions in the area of misbehaviour detection in C-ITS. In doing so, this study contributes to the existing literature in an important field of study.
Spatiotemporal Drivers of the African Swine Fever Epidemic in Lao PDR
Authors: Hui Ka Yi , Matsumoto Nina , Siengsanan-Lamont Jarunee , Young James R. , Khounsy Syseng , Douangneun Bounloum , Thepagna Watthana , Phommachanh Phouvong , Blacksell Stuart D. , Ward Michael P. 
Published: May 2023

African swine fever (ASF) is a devastating transboundary disease of swine. Following the first report of ASF in China in August 2018, ASF spread through South-East Asian nations in 2019. Without control and containment measures, ASF can decimate smallholder pig holdings and disrupt value chains. This study aimed to describe the spatiotemporal spread of the 2019 Lao PDR ASF epidemic in domestic pigs, identify environmental (protected areas and forests), production (pig ownership), transportation (roads), and social (poverty and ethnicity) risk factors, and recommend measures that could reduce ASF spread. A retrospective spatiotemporal study was conducted at the village level. Information on the date that ASF was first reported from each case location was collected, and the outcome variable of interest “epidemic day” was created. Risk factor information from different sources was extracted for each case location. The association or correlation between epidemic day and risk factors for the spread of ASF was investigated using Kruskal–Wallis tests and Spearman rank correlation statistics. The epidemic started on June 16 and lasted for 190 days, displaying a right-skewed epidemic curve. The directional distribution was rotated approximately 305°, from Southeast to Northwest Laos. Significant risk factors for ASF associated with epidemic day were location in terms of distance from the closest protected natural area

P
=
0.020

, pig ownership

P
=
0.005

, road networks

P
=
0.003

, and poverty indices

P
<
0.001

. Cases were reported earlier in this epidemic at locations that were closer to protected natural areas, of higher pig ownership, more connected via the national road network, and which experienced elevated poverty. The spatiotemporal pattern described suggests that ASF was introduced via infected pigs from Vietnam. Based on study findings, recommendations for smallholder pig production in Southeast Asia include improving knowledge of swine value chains to inform disease risk and control, monitoring pig transportation, implementing stricter biosecurity measures on the domestic pig population, and providing biosecurity support and education to smallholder pig farmers in poverty.
Hepatocellular Carcinoma Surveillance among Individuals with Cirrhosis: Trends by Payer, Etiology, and Calendar Year, from a Statewide, Multi-Payer Dataset, 2010–2018
Authors: Hsu Christine D. , Henderson Louise M. , Jackson Bradford E. , Baggett Christopher D. , Funk Michele Jonsson , Olshan Andrew F. , Gupta Parul , Barritt A. Sidney , Sanoff Hanna K. , Wheeler Stephanie B. , Moon Andrew M. , Lund Jennifer L. 
Published: May 2023

Abstract

Background:
Hepatocellular carcinoma (HCC) surveillance is underutilized, with &lt;25% of individuals with cirrhosis receiving surveillance exams as recommended. The epidemiology of cirrhosis and HCC in the United States has also shifted in recent years, but little is known about recent trends in surveillance utilization. We characterized patterns of HCC surveillance by payer, cirrhosis etiology, and calendar year in insured individuals with cirrhosis.

Methods:
We conducted a retrospective cohort study of individuals with cirrhosis using claims data from Medicare, Medicaid, and private insurance plans in North Carolina. We included individuals ≥ 18 years with a first occurrence of an ICD-9/10 code for cirrhosis between January 1, 2010, and June 30, 2018. The outcome was HCC surveillance by abdominal ultrasound, CT, or MRI. We estimated 1- and 2-year cumulative incidences for HCC surveillance and assessed longitudinal adherence to surveillance by computing the proportion of time covered (PTC).

Results:
Among 46,052 individuals, 71% were enrolled through Medicare, 15% through Medicaid, and 14% through private insurance. The overall 1-year cumulative incidence of HCC surveillance was 49% and the 2-year cumulative incidence was 55%. For those with an initial screen in the first 6 months of their cirrhosis diagnosis, the median 2-year PTC was 67% (Q1, 38%; Q3, 100%).

Conclusions:
HCC surveillance initiation after cirrhosis diagnosis remains low, though it has improved slightly over time, particularly among individuals with Medicaid.

Impact:
This study provides insight into recent trends in HCC surveillance and highlights areas to target for future interventions, particularly among patients with nonviral etiologies.
Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity
Authors: Sukeda Nao , Fujigaki Hidetsugu , Ando Tatsuya , Ando Honomi , Yamamoto Yasuko , Saito Kuniaki 
Published: May 2023

Abstract
Cisplatin is a chemotherapeutic agent used to treat many types of malignant tumors. However, irrespective of its potent anticancer properties and efficacy, nephrotoxicity is the dose-limiting factor of cisplatin treatment. Cisplatin infiltrates renal tubular cells in the kidneys and is metabolized by cysteine conjugate-beta lyase 1 (CCBL1) to form highly reactive thiol-cisplatin; this may mediate cisplatin's nephrotoxicity. Therefore, CCBL1 inhibition may prevent cisplatin-induced nephrotoxicity. Using a high-throughput screening assay, we identified 2′,4′,6′-trihydroxyacetophenone (THA) as an inhibitor of CCBL1. THA inhibited human CCBL1 β-elimination activity in a concentration-dependent manner. We further investigated the preventive effect of THA on cisplatin-induced nephrotoxicity. THA attenuated the effect of cisplatin on the viability of confluent renal tubular cells (LLC-PK1 cells) but had no effect on cisplatin-induced reduction of proliferation in the tumor cell lines (LLC and MDA-MB-231). THA pretreatment significantly attenuated cisplatin-induced increases in blood urea nitrogen, creatinine, cell damage score, and apoptosis of renal tubular cells in mice in a dose-dependent manner. Furthermore, THA pretreatment attenuated cisplatin-induced nephrotoxicity without compromising its antitumor activities in mice bearing subcutaneous syngeneic LLC tumors. THA could help prevent cisplatin-induced nephrotoxicity and may provide a new strategy for cisplatin-inclusive cancer treatments.
Arsenals of Knowledge: Reconstructing the Contents and Purpose of the Lost Jesuit Libraries of Northern Mexico
Authors: Manrique Figueroa César 
Published: May 2023

Abstract
This article examines several libraries assembled by the Society of Jesus in their college and missions in Northern Mexico (in the present-day Mexican State of Chihuahua), where Jesuits have been a constant presence from the seventeenth century, interrupted only temporarily by the Society’s suppression. All their bibliographic collections were transferred, dispersed, or looted after the general expulsion of 1767. Archival materials preserved in repositories such as the Archivo General de la Nación in Mexico City, however, enable a reconstruction of these libraries. This essay argues that these collections constituted a sort of “cultural oasis” (Michael Mathes). They provided arsenals of knowledge for missionaries in distant places with harsh living conditions and show the strong and lasting bond between Jesuits and print culture even in the most remote and adverse of conditions.
Wind Turning in the Planetary Boundary Layer in CMIP6 Models
Authors: Pyykkö Joakim , Svensson Gunilla 
Published: May 2023

Abstract
A set of CMIP6 models is evaluated for the turning of the wind over the planetary boundary layer (PBL) and the corresponding cross-isobaric mass flux. The bulk Richardson number method is used to calculate the height of the PBL to allow for comparisons with a climatology of observed wind-turning angles documented by Lindvall and Svensson based on more than 800 stations in the Integrated Global Radiosonde Archive. Wind-turning angles are found to be underestimated in all models, with the GFDL CM4 model having the closest distribution to the observations. Large, negative cross-isobaric mass fluxes (flow toward higher pressure) are found over high-terrain areas and the North Atlantic storm-track region in all models and the ERA-Interim reanalysis. Bulk Richardson number–derived PBLs are particularly shallow in the Norwegian Earth System Model, medium atmosphere-medium ocean resolution (NorESM2-MM), likely caused by a change in the turbulence and cloud scheme as compared to the CESM2 model that uses the same atmospheric model, leading to small wind-turning angles and cross-isobaric mass fluxes. Using the 850-hPa level as the upper boundary broadens the wind-turning angle distribution and increases the amount of cross-isobaric mass flux for all models. This makes the models closer to the observations, although substantial differences are still present. The assumption of a constant geostrophic wind throughout the PBL possibly affects the calculated mass fluxes.