bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review
Authors: Dobosz Maciej , Rudziński Gracjan , Chilimoniuk Zuzanna , Więsyk Piotr , Kusak Natalia , Chałupnik Aleksandra 
Published: January 2023

Introduction and purpose: More and more reports suggest that diabetes plays an important role in the pathogenesis of Alzheimer's disease (AD). Understanding this link may provide a new approach to modulating the onset and progression of sporadic AD cases. The aim of the study is to present the current state of knowledge on the basic mechanisms and factors influencing the development of AD in patients with type 2 diabetes in the context of clinical practice.
State of knowledge: It is estimated that up to 80% of Alzheimer's patients have glucose intolerance or diabetes. Impaired insulin signaling can lead to abnormal processing and accumulation of beta-amyloid protein, which can result in memory deficits and cognitive decline. Insulin deficiency can also cause over-activity of the GSK3 enzyme, leading to tau hyperphosphorylation and senile plaque accumulation. Diabetes can also cause fibrotic changes in cerebral vessels, disrupting brain metabolism and potentially leading to hippocampus atrophy. The release of cytokines during the metabolic syndrome can also cause oxidative stress and neuroinflammation, which may contribute to neuronal atrophy. It has been reported that healthy diet, physical exercises and prevention of metabolic diseases may reduce the incidence of AD.
Conclusions: Epidemiological data and pathophysiological studies indicate a significant relationship between these diseases that AD is sometimes called Type 3 diabetes. Early detection of hyperglycemia and its proper management, may be crucial in the context of the clinical prevention of dementia diseases. It is essential to pay attention to the cognitive abilities of patients with metabolic diseases.
Seminaria naukowe Ośrodka Badań nad Kulturą Ormiańską w Polsce w latach 2019-2022 – przyczynek do poznania najnowszego etapu kształtowania się armenologii polskiej
Authors: Wasyl Franciszek , Zięba Andrzej A. 
Published: January 2023

SEMINARS OF THE RESEARCH CENTER FOR ARMENIAN CULTURE IN POLAND IN THE YEARS 2019-2022
This is the thematic analysis of tutorial meetings, organised in the Research Center for Armenian Culture in Poland (Polish Academy of Arts and Sciences in Krakow) in the years 2019-2022.
Noticias
Authors: Notícias Transfer 
Published: January 2023

Congreso:“PortlandStateInternational Conference on Translation Studies, Cross-cultural Communication, and Chinese Pedagogy”, Portland State University, Portland, OregonOct. 24-25, 2008Deadline for abstracts: May 30, 2008. Send abstracts to Dr. Meiru Liu at lium@pdx.edu or Dr. Xuanmin Luo at luoxm@mail.tsinghua.edu.cn For more information see the conference website at http://ci.oia.pdx.edu or http://www.tsinghua-translation.org.cn Congreso:"International Conference on Intercultural Studies" 9 December 2008, University of Oporto, Portugal. <http://www.iscap.ipp.pt/~cei/congresso.htm> Abstracts of papers in intercultural studies are invited to submit in Portuguese, English, French, German, or Spanish in 250 words and a bionote of 100 words by 15 June 2008 to <cei@iscap.ipp.pt>. Curso:“International Literary Translation Summer School”, The British Centre for Literary Translation.Registration is now open. For more information and registration details, please visit the BCLT website: www.uea.ac.uk/bclt. Revista:“TransLit” Volume 8, An Anthology of Literary Translation.The Literary Translation Collective of the Association of Translators and Interpreters of Alberta (ATIA) is producing the eighth volume of TransLit for publication in spring 2009, in co-operation with the Literary Translators’ Association of Canada (LTAC). TransLit Volume 8 is a special themed issue titled “Poetry and Short Stories of theAmericas”.Send your contribution by July 1st, 2008to Marc Charron and Luise von Flotow, editors of TransLit Volume 8 to the following address: Editors TransLit Volume 8 School of Translation and Interpretation University of Ottawa Arts Building, 4th Floor Ottawa, OntarioCANADAK1N 6N5 Curso:“CETRA 2008 Doctoral Summer Research Programme”, 18-29 August 2008, Katholieke Universiteit Leuven, Belgium. For the provisional programme and for the application procedure and other administrative information, please visit our website: http://www.kuleuven.be/cetra/Summer_School/summerschool.html http://www.kuleuven.be/cetra/programme/programme.html http://www.kuleuven.be/cetra/Summer_School/applicationprocedure.html For additional information: - please contact Reine Meylaerts, CETRA director (reine.meylaerts@arts.kuleuven.be) and/or Steven Dewallens (steven.dewallens@hubrussel.be) Curso:“2008 NidaSchoolfor Translation Studies”, Sept 8-20, 2008, Misano Adriatico (Rimini), Italy, www.istitutosanpellegrino.com/ssmlFor additional information, please contact Dulce Alvarado (DAlvarado@americanbible.org;
Alignment with a combination of deflectometry and the sine condition test
Authors: Yoo Hyemin , Dubin Matthew 
Published: January 2023

We propose a new alignment method that is based on relative
measurements with an on-axis test setup composed of a pixelated camera
and a monitor. By combining deflectometry and the sine condition test,
the new method eliminates the necessity of moving a test instrument to
multiple field points but still estimates the state of alignment by
measuring both the off-axis and on-axis performances of the system.
Additionally, it can be a very cost-effective option for certain
projects as a monitor, and a camera may be substituted for the return
optic and the interferometer required in a conventional
interferometric method. We explain the concept of the new alignment
method using a meter-class Ritchey–Chrétien telescope. Additionally,
we present a new metric, the Metric for Misalignment Indicators (MMI),
which represents the transmitted wavefront error caused by
misalignment in the system. Then we demonstrate the validity of the
concept using simulations where a poorly aligned telescope is the
starting point to show that this method has a larger dynamic range
compared to the interferometric method. Even considering realistic
levels of noise, the new alignment method works successfully, as there
is an improvement of two orders of magnitude in the
final MMI after three iterations of alignment. The MMI of perturbed
telescope models is about 10 µm but, after alignment,
the MMI converges to one-tenth of a micrometer.
Assessment of community perceptions and risk to common zoonotic diseases among communities living at the human-livestock-wildlife interface in Nakuru West, Kenya: A participatory epidemiology approach
Authors: Owiny Maurice Omondi , Ngare Ben Kipchumba , Mugo Bernard Chege , Rotich Jacob , Mutembei Arithi , Chepkorir Khadijah , Sitawa Rinah , Obonyo Mark , Onono Joshua Orungo 
Published: January 2023

Background
Zoonoses account for most of the emerging and re-emerging infections in Kenya and in other low to medium-income countries across the world. The human-livestock-wildlife interface provides a nexus where transmission and spread of these zoonotic diseases could occur among communities farming in these areas. We sought to identify perceptions of the community living near the Lake Nakuru National Park in Kenya.

Methods
We used participatory epidemiology techniques (PE) involving Focus Group Discussion (FGD) among community members and Key Informant Interviews (KII) with the health, veterinary, and administration officers in July 2020. We used listing, pairwise matching, and proportional piling techniques during the FGDs in the randomly selected villages in the study area from a list of villages provided by the area government officers. Kruskal–Wallis test was used to compare the median scores between the zoonotic diseases, source of information, and response to disease occurrence. Medians with a z-score greater than 1.96 at 95% Confidence Level were considered to be significant. Content analysis was used to rank qualitative variables.

Results
We conducted seven FGDs and four KIIs. A total of 89 participants took part in the FGDs with their ages ranging from 26 to 85 years. Common zoonotic diseases identified by participants included anthrax, rabies, and brucellosis. Anthrax was considered to have the greatest impact by the participants (median = 4, z>1.96), while 4/7 (57%) of the FGDs identified consumption of uninspected meat as a way that people can get infected with zoonotic diseases. Community Health Volunteers (Median = 28, z = 2.13) and the government veterinary officer (median = 7, z = 1.8) were the preferred sources of information during disease outbreaks.

Conclusion
The participants knew the zoonotic diseases common in the area and how the diseases can be acquired. We recommend increased involvement of the community in epidemio-surveillance of zoonotic diseases at the human-wildlife-livestock interface.
Prevalence and risk predictors of childhood stunting in Bangladesh
Authors: Abdulla Faruq , Rahman Azizur , Hossain Md. Moyazzem 
Published: January 2023

Background
The child nutritional status of a country is a potential indicator of socioeconomic development. Child malnutrition is still the leading cause of severe health and welfare problems across Bangladesh. The most prevalent form of child malnutrition, stunting, is a serious public health issue in many low and middle-income countries. This study aimed to investigate the heterogeneous effect of some child, maternal, household, and health-related predictors, along with the quantiles of the conditional distribution of Z-score for height-for-age (HAZ) of under five children in Bangladesh.

Methods and materials
In this study, a sample of 8,321 children under five years of age was studied from BDHS-2017-18. The chi-square test was mainly used to identify the significant predictors of the HAZ score and sequential quantile regression was used to estimate the heterogeneous effect of the significant predictors at different quantiles of the conditional HAZ distribution.

Results
The findings revealed that female children were significantly shorter than their male counterparts except at the 75th quantile. It was also discovered that children aged 7–47 months were disadvantaged, but children aged 48–59 months were advantaged in terms of height over children aged 6 months or younger. Moreover, children with a higher birth order had significantly lower HAZ scores than 1st birth order children. In addition, home delivery, the duration of breastfeeding, and the BCG vaccine and vitamin A received status were found to have varied significant negative associations with the HAZ score. As well, seven or fewer antenatal care visits was negatively associated with the HAZ score, but more than seven antenatal care visits was positively associated with the HAZ score. Additionally, children who lived in urban areas and whose mothers were over 18 years and either normal weight or overweight had a significant height advantage. Furthermore, parental secondary or higher education had a significant positive but varied effect across the conditional HAZ distribution, except for the mother’s education, at the 50th quantile. Children from wealthier families were also around 0.30 standard deviations (SD) taller than those from the poorest families. Religion also had a significant relationship with the conditional HAZ distribution in favor of non-Muslim children.

Conclusions
To enhance children’s nutritional levels, intervention measures should be designed considering the estimated heterogeneous effect of the risk factors. This would accelerate the progress towards achieving the targets of Sustainable Development Goals (SDGs) related to child and maternal health in Bangladesh by 2030.
Indonesia’s Innovation Policies: Evolution and Institutional Structure
Authors: Simatupang Togar M. , Silalahi Fitriani Tupa R , Okdinawati Liane , Nandini Widya , Fajarini Putu Franciska 
Published: January 2023

<p class="16" align="justify"><span>Along with world developments that encourage every country to innovate, Indonesia also has aspirations to increase domestic innovation. The success of several other countries in increasing economic growth through innovation is the driving force. Indonesia also has the same desire to pay attention to innovation and science, and technology. Along the way, there have been developments in innovation policies in Indonesia in terms of institutional structure and implementation of innovative programs. This paper tries to identify how the innovation policy has developed through quantitative analysis of innovation, science and technology regulations starting in 2004. This paper has divided the regulations into four eras according to the era of the elected President from 2004 to 2024. A multi-dimensional quantitative methodology is carried out to examine Indonesia's innovation policies</span><span>.</span><span> The policy search is carried out by searching for regulations in two Indonesian regulatory databases. From the analysis results, it is found that Indonesia has driven S&amp;T and innovation policies, including policies that support innovation funding and has </span><span>made several changes to the formation of innovation organizations to produce better coordination between researchers who create innovative products and industries as users.</span></p>
Malignant Insulinoma Arising From Nonfunctioning Pancreatic Neuroendocrine Tumor
Authors: Chatterjee Ritodhi , Ali Basim , Nguyen Son H. , Chen Rui , Sada Yvonne H. 
Published: January 2023

ABSTRACTPancreatic neuroendocrine tumors are rare neoplasms characterized into nonfunctioning (NF-PNET) and functioning (F-PNET) subtypes. F-PNETs typically involve overt symptoms related to excessive hormone secretion but may rarely present first as NF-PNETs with delayed transformation. We present a patient with known NF-PNET with liver metastases who developed hypoglycemia 2 years after initial diagnosis due to malignant insulinoma. Hypoglycemia was refractory to continuous dextrose but improved temporarily after diazoxide and hepatic artery embolization. Malignant insulinomas are usually metastatic at presentation and portend poor prognosis. Hypoglycemia may be medically managed with steroids, somatostatin analogues, and diazoxide, along with therapies to reduce tumor burden.
Green Bonds
Authors: Cristina da Silva Pereira Giovana , Alves Amaral Lais Greice , Pereira da Silva Narrylle , Jacobi Kölling Gabrielle 
Published: January 2023

A responsabilidade social, aliada à governança corporativa, proporciona diversas possibilidades e reflexões para os vários atores envolvidos no cenário econômico, social e jurídico, uma vez que implica o compromisso dos negócios de contribuir para o desenvolvimento econômico sustentável. Tem como ponto base o aprofundamento diante da responsabilidade social que implica um comportamento ético e transparente, que contribua para o desenvolvimento sustentável, que esteja em conformidade com as leis aplicáveis e seja consistente com as normas internacionais de comportamento. Assim, a pretensão do artigo é analisar e conhecer a relação da governança corporativa com a responsabilidade social e com o meio ambiente, especialmente no contexto dos títulos verdes ou green bonds na regulação brasileira. Por fim, é importante verificar o potencial do mercado brasileiro para títulos verdes no agronegócio, na energia renovável e no saneamento. Essas questões abordadas e a temática citada é de suma importância para um desenvolvimento dos incentivos ambientais atrelados a economia, mostrando que ambos podem caminhar em consonância para o bem-estar maior da população tanto quanto a saúde ambiental e econômica. Diante destes cenários, o desenvolvimento de dados de pesquisa encontra-se em andamento para a possibilidade de um aprofundamento técnico mais objetivo, buscando citar não apenas o Brasil, mas sim a esfera mundial do tema abordado, seus impactos, rendimentos, implementações, investidores e possível crescimento.
Palavras-chave: sustentabilidade, responsabilidade social, títulos verdes, regulação.
Using logistic regression models to investigate the effects of high-sensitivity cardiac troponin T confounders on ruling in acute myocardial infarction
Authors: Liu Li , Cai Xueya , Love Tanzy , Corsetti Matthew , Mathias Andrew M. , Worster Andrew , Ma Jinhui , Kavsak Peter A. 
Published: January 2023

Abstract

Objectives
Confounding factors, including sex, age, and renal dysfunction, affect high-sensitivity cardiac troponin T (hs-cTnT) concentrations and the acute myocardial infarction (AMI) diagnosis. This study assessed the effects of these confounders through logistic regression models and evaluated the diagnostic performance of an optimized, integrated prediction model.

Methods
This retrospective study included a primary derivation cohort of 18,022 emergency department (ED) patients at a US medical center and a validation cohort of 890 ED patients at a Canadian medical center. Hs-cTnT was measured with 0/3 h sampling. The primary outcome was index AMI diagnosis. Logistic regression models were optimized to predict AMI using delta hs-cTnT and its confounders as covariates. The diagnostic performance of model cutoffs was compared to that of the hs-cTnT delta thresholds. Serial logistic regressions were carried out to evaluate the relationship between covariates.

Results
The area under the curve of the best-fitted model was 0.95. The model achieved a 90.0% diagnostic accuracy in the validation cohort. The optimal model cutoff yielded comparable performance (90.5% accuracy) to the optimal sex-specific delta thresholds (90.3% accuracy), with 95.8% agreement between the two diagnostic methods. Serial logistic regressions revealed that delta hs-cTnT played a more predominant role in AMI prediction than its confounders, among which sex is more predictive of AMI (total effect coefficient 1.04) than age (total effect coefficient 0.05) and eGFR (total effect coefficient −0.008).

Conclusions
The integrated prediction model incorporating confounding factors does not outperform hs-cTnT delta thresholds. Sex-specific hs-cTnT delta thresholds remain to provide the highest diagnostic accuracy.
On the hydrothermal depolymerisation of kraft lignin using glycerol as a capping agent
Authors: Ahlbom Anders , Maschietti Marco , Nielsen Rudi , Hasani Merima , Theliander Hans 
Published: January 2023

Abstract
Depolymerisation of kraft lignin under hydrothermal conditions was investigated at short residence times (1–12 min) with glycerol being used as a capping agent. The weight average molecular weight (M
w) of the products decreased within the first minute of residence time, with the inter-unit ether linkages breaking accordingly. Furthermore, the M
w of the product fractions decreased at increasing residence times, while the char yield increased. Short residence times thus appear to be beneficial for mitigating the formation of char. Also, addition of NaOH reduced the yield of char. Although the addition of glycerol caused a decrease in the M
w of the products, it seemed to increase the yield of char and therefore might not be a suitable capping agent for kraft lignin depolymerisation.
Low system justification drives ideological differences in joke perception: a critical commentary and re-analysis of Baltiansky et al. (2021)
Authors: Purser Harry R. M. , Harper Craig A. 
Published: January 2023

AbstractA recent study by Baltiansky et al. (2021), which was published inHUMOR: International Journal of Humor Researchtested two hypotheses related to system justification and the perception of stereotypical humor. They reported to have found evidence for a cross-over interaction, with judgments of jokes being contingent on a combination of the social status of the targets of jokes and raters’ system justification motivations. Here, we discuss the original analysis, presentation, and interpretation of the data in the target article, before presenting a re-analysis of the authors’ shared data file. We show that the framing of claims such as that “high system-justifiers found jokes targeting low-status groups (e.g., women, poor people, racial/ethnic minorities) to be funnier than low system-justifiers did” are misleading. Instead, our re-analyses suggest that ideological differences in joke perception are driven primarily by those scoring low on the system justification motivation rating jokes about ostensibly low-status groups as less funny than jokes about other social groups.
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Authors: Fröhlich Fabian , Gerosa Luca , Muhlich Jeremy , Sorger Peter K 
Published: January 2023

AbstractBRAF is prototypical of oncogenes that can be targeted therapeutically and the treatment of BRAFV600E melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug‐induced rewiring generates a drug adapted state thought to be involved in acquired resistance and disease recurrence. In this article, we study mechanisms of adaptive rewiring in BRAFV600E melanoma cells using an energy‐based implementation of ordinary differential equation (ODE) modeling in combination with proteomic, transcriptomic and imaging data. We develop a method for causal tracing of ODE models and identify two parallel MAPK reaction channels that are differentially sensitive to RAF and MEK inhibitors due to differences in protein oligomerization and drug binding. We describe how these channels, and timescale separation between immediate‐early signaling and transcriptional feedback, create a state in which the RAS‐regulated MAPK channel can be activated by growth factors under conditions in which the BRAFV600E‐driven channel is fully inhibited. Further development of the approaches in this article is expected to yield a unified model of adaptive drug resistance in melanoma.
Cross-species comparison of mouse and human preimplantation development with an emphasis on lineage specification
Authors: Biondic Savana , Canizo Jesica , Vandal Katherine , Zhao Cheng , Petropoulos Sophie 
Published: January 2023

In brief
Human embryogenesis still remains largely unexplored. This review helps identify some of our current gaps in knowledge pertaining to preimplantation development, which may have implications for understanding fundamental aspects of human development, assisted reproductive technologies, and stem cell biology.

Abstract
Preimplantation development is arguably one of the most critical stages of embryogenesis. Beginning with the formation of the totipotent zygote post-fertilization, a series of cell divisions, and a complex coordination of physical cues, molecular signals and changes in gene expression lead to the formation of the blastocyst, a structure capable of implanting into the uterine wall. The blastocyst is composed of more specified cellular lineages, which will give rise to every tissue of the developing organism as well as the extra-embryonic lineages which support fetal growth. While the mouse has been used as a model to understand the events of preimplantation development for decades, in recent years, an expanding body of work has been conducted using the human embryo. These studies have identified some crucial species differences, particularly in the transcriptional and spatio-temporal expression of lineage markers and responses to cell signaling perturbations. This review compares recent findings on preimplantation development in mouse and human, with a focus on the specification of the first cellular lineages. Highlighting differences and noting mechanisms that require further examination in the human embryo is of critical importance for both the accurate translation of results from the mouse model and our overall understanding of mammalian development. We further highlight the latest advancement in reproductive research, the development of the 3D stem cell-based models known as ‘blastoids’. The knowledge discussed in this review has major clinical implications for assisted reproductive technologies such as in vitro fertilization and for applications in stem cell biology.