bluuebunny/crossref_metadata_2025_split huggingface dataset:
Best selected forecasting models for COVID-19 pandemic
Authors: Fayomi Aisha , Nasir Jamal Abdul , Algarni Ali , Rasool Muhammad Shoaib , Jamal Farrukh , Chesneau Christophe 
Published: January 2023

Abstract
This study sought to identify the most accurate forecasting models for COVID-19-confirmed cases, deaths, and recovered patients in Pakistan. For COVID-19, time series data are available from 16 April to 15 August 2021 from the Ministry of National Health Services Regulation and Coordination’s health advice portal. Descriptive as well as time series models, autoregressive integrated moving average, exponential smoothing models (Brown, Holt, and Winters), neural networks, and Error, Trend, Seasonal (ETS) models were applied. The analysis was carried out using the R coding language. The descriptive analysis shows that the average number of confirmed cases, COVID-19-related deaths, and recovered patients reported each day were 2,916, 69.43, and 2,772, respectively. The highest number of COVID-19 confirmed cases and fatalities per day, however, were recorded on April 17, 2021 and April 27, 2021, respectively. ETS (M, N, M), neural network, nonlinear autoregressive (NNAR) (3, 1, 2), and NNAR (8, 1, 4) forecasting models were found to be the best among all other competing models for the reported confirmed cases, deaths, and recovered patients, respectively. COVID-19-confirmed outbreaks, deaths, and recovered patients were predicted to rise on average by around 0.75, 5.08, and 19.11% daily. These statistical results will serve as a guide for disease management and control.
TFA als persistentes Abbauprodukt fluorierter Kohlenwasserstoffe
Authors: Behringer David 
Published: January 2023

Zusammenfassung
Die hochmobile und stark persistente Trifluoressigsäure (TFA) ist ein Abbauprodukt vieler fluorierter Kohlenwasserstoffe, die insbesondere als Kältemittel eingesetzt werden. TFA reichert sich als Trifluoracetat in steigender Konzentration in Grund- und Trinkwasser an. Da mögliche negative Folgen einer dauerhaften Exposition zunehmender Mengen an Trifluoracetat für Mensch und Umwelt nicht hinreichend bekannt sind, sollte der Einsatz TFA-bildender Kohlenwasserstoffe umgehend unterbunden werden.
Renaturierung von Still- und Fließgewässern zum Schutz der menschlichen Gesundheit
Authors: Zerbe Stefan 
Published: January 2023

Zusammenfassung
Die Renaturierung von Ökosystemen ist spätestens mit der Proklamation der „Dekade der Ökosystemrenaturierung 2021-2030“ durch die UN auf die globale Umweltagenda gekommen. Eine Herausforderung der nahen Zukunft wird es sein, die Oberflächengewässer und das Grundwasser dahingehend in ihren ökologischen Funktionen und Leistungen aufzuwerten, dass diese in vollem Umfang ihre positiven Wirkungen auf die physische und psychische Gesundheit des Menschen entfalten können.
Zero Water Day: seizing the opportunity from a public health perspective
Authors: Fisher Julian , Kalin Robert M. , Krebs Jan , Buijs Goof , Roy Aparna , Wille Christina , Buse Kent 
Published: January 2023

AbstractWater is a finite natural resource. Zero Water Day(s) scenarios are challenging people and communities in Europe and worldwide. The public health community must seize the opportunity to prepare for Zero Water Day(s) through strengthening capacity and capability to respond to rapidly emerging emergencies as well as protected crises. Collaboration across sectors on water conservation and public health is key to tackling the consumptive environment and extractive economic systems.
Volatility and dependence in cryptocurrency and financial markets: a copula approach
Authors: Liu Jinan , Serletis Apostolos 
Published: January 2023

Abstract
We use a semiparametric GARCH-in-Mean copula model to examine the volatility dynamics and tail dependence between cryptocurrency markets and financial markets. We do not find any statistically significant tail dependence between the financial and cryptocurrency markets, but we find lower tail dependence between Bitcoin and stock returns. There is lower tail dependence among Bitcoin, Ethereum, and Litecoin, and the lower tail dependence between Ethereum and Litecoin returns is the strongest. The GARCH-in-Mean model shows that the uncertainty effect on cryptocurrency returns is not statistically significant, while uncertainty has a negative and statistically significant effect on Bitcoin returns. The fact that there is no tail dependence between cryptocurrency and the interest rate or the effective exchange rate of U.S. dollar suggests that cryptocurrency could offer safe haven, defined as an asset that is uncorrelated with stocks and bonds.
Do digital information and communication technologies in social work practice increase the quality and effectiveness of work?
Authors: Tóth Larissza , Jávor Rebeka 
Published: January 2023

The objective of this paper is to familiarize readers with the contemporary questions and issues of ICTs in social work practice in Hungary. Exploring the question includes the ethical dilemmas involved, as well as potential answers to the following questions: How often do professionals use IT tools during their work? What tools do they use? How do clients accept these? Do professionals think it is necessary to develop their IT competencies? In addition to a comprehensive descriptive analysis of the data, comparative analyses were also conducted according to age groups, place of living and specialty areas.
The article was received: 21. 10. 2022., revised: 14. 11. 2022., accepted: 27. 12. 2022.
LETRAMENTO DIGITAL DE PROFESSORES DE LÍNGUAS
Authors: Lacerda Rabello Cíntia Regina , Da Silva Cardoso Janaína 
Published: January 2023

O presente artigo discute a necessidade de os cursos de formação inicial de professores de línguas incluírem a integração das tecnologias digitais e o desenvolvimento do letramento digital dos licenciandos em Letras em seus currículos. Em seguida, apresenta resultados parciais de pesquisas-ação realizadas com base em duas disciplinas optativas voltadas para esse fim em duas universidades públicas no Rio de Janeiro. Apesar dos resultados positivos em relação às contribuições das disciplinas para o letramento digital dos licenciandos, compreendemos que essa formação não deve estar restrita à oferta de disciplinas isoladas e optativas, como apontado por Marzani e Leffa (2013), mas permear toda a formação dos professores de línguas.
Arc-Expressing Accessory Olfactory Bulb Interneurons Support Chemosensory Social Behavioral Plasticity
Authors: Zuk Kelsey E. , Cansler Hillary L. , Wang Jinxin , Meeks Julian P. 
Published: January 2023

The accessory olfactory system (AOS) is critical for the development and expression of social behavior. The first dedicated circuit in the AOS, the accessory olfactory bulb (AOB), exhibits cellular and network plasticity in male and female mice after social experience. In the AOB, interneurons called internal granule cells (IGCs) express the plasticity-associated immediate-early geneArcfollowing intermale aggression or mating. Here, we sought to better understand howArc-expressing IGCs shape AOB information processing and social behavior in the context of territorial aggression. We used “ArcTRAP” (Arc-CreERT2) transgenic mice to selectively and permanently labelArc-expressing IGCs following male–male resident–intruder interactions. Using whole-cell patch-clamp electrophysiology, we found thatArc-expressing IGCs display increased intrinsic excitability for several days after a single resident–intruder interaction. Further, we found thatArc-expressing IGCs maintain this increased excitability across repeated resident–intruder interactions, during which resident mice increase or “ramp” their aggression. We tested the hypothesis thatArc-expressing IGCs participate in ramping aggression. Using a combination of ArcTRAP mice and chemogenetics (Cre-dependent hM4D(Gi)-mCherry AAV injections), we found that disruption ofArc-expressing IGC activity during repeated resident–intruder interactions abolishes the ramping aggression exhibited by resident male mice. This work shows thatArc-expressing AOB IGC ensembles are activated by specific chemosensory environments, and play an integral role in the establishment and expression of sex-typical social behavior. These studies identify a population of plastic interneurons in an early chemosensory circuit that display physiological features consistent with simple memory formation, increasing our understanding of central chemosensory processing and mammalian social behavior.SIGNIFICANCE STATEMENTThe accessory olfactory system plays a vital role in rodent chemosensory social behavior. We studied experience-dependent plasticity in the accessory olfactory bulb and found that internal granule cells expressing the immediate-early geneArcafter the resident–intruder paradigm increase their excitability for several days. We investigated the roles of theseArc-expressing internal granule cells on chemosensory social behavior by chemogenetically manipulating their excitability during repeated social interactions. We found that inhibiting these cells eliminated intermale aggressive ramping behavior. These studies identify a population of plastic interneurons in an early chemosensory circuit that display physiological features consistent with simple memory formation, increasing our understanding of central chemosensory processing and mammalian social behavior.
A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars
Authors: Kalyanasundar B. , Blonde Ginger D. , Spector Alan C. , Travers Susan P. 
Published: January 2023

Recent findings from our laboratory demonstrated that the rostral nucleus of the solitary tract (rNST) retains some responsiveness to sugars in double-knock-out mice lacking either the T1R1+T1R3 (KO1+3) or T1R2+T1R3 (KO2+3) taste receptor heterodimers. Here, we extended these findings in the parabrachial nucleus (PBN) of male and female KO1+3 mice using warm stimuli to optimize sugar responses and employing additional concentrations and pharmacological agents to probe mechanisms. PBN T1R-independent sugar responses, including those to concentrated glucose, were more evident than in rNST. Similar to the NST, there were no “sugar-best” neurons in KO1+3 mice. Nevertheless, 1000 mmglucose activated nearly 55% of PBN neurons, with responses usually occurring in neurons that also displayed acid and amiloride-insensitive NaCl responses. In wild-type (WT) mice, concentrated sugars activated the same electrolyte-sensitive neurons but also “sugar-best” cells. Regardless of genotype, phlorizin, an inhibitor of the sodium-glucose co-transporter (SGLT), a component of a hypothesized alternate glucose-sensing mechanism, did not diminish responses to 1000 mmglucose. The efficacy of concentrated sugars for driving neurons broadly responsive to electrolytes implied an origin from Type III taste bud cells. To test this, we used the carbonic anhydrase (CA) inhibitor dorzolamide (DRZ), previously shown to inhibit amiloride-insensitive sodium responses arising from Type III taste bud cells. Dorzolamide had no effect on sugar-elicited responses in WT sugar-best PBN neurons but strongly suppressed them in WT and KO1+3 electrolyte-generalist neurons. These findings suggest a novel T1R-independent mechanism for hyperosmotic sugars, involving a CA-dependent mechanism in Type III taste bud cells.SIGNIFICANCE STATEMENTSince the discovery ofTas1rreceptors for sugars and artificial sweeteners, evidence has accrued that mice lacking these receptors maintain some behavioral, physiological, and neural responsiveness to sugars. But the substrate(s) has remained elusive. Here, we recorded from parabrachial nucleus (PBN) taste neurons and identified T1R-independent responses to hyperosmotic sugars dependent on carbonic anhydrase (CA) and occurring primarily in neurons broadly responsive to NaCl and acid, implying an origin from Type III taste bud cells. The effectiveness of different sugars in driving these T1R-independent responses did not correlate with their efficacy in driving licking, suggesting they evoke a nonsweet sensation. Nevertheless, these salient responses are likely to comprise an adequate cue for learned preferences that occur in the absence of T1R receptors.
Spontaneous Activity of the Local GABAergic Synaptic Network Causes Irregular Neuronal Firing in the External Globus Pallidus
Authors: Jones James A. , Higgs Matthew H. , Olivares Erick , Peña Jacob , Wilson Charles J. 
Published: January 2023

Autonomously firing GABAergic neurons in the external globus pallidus (GPe) form a local synaptic network. In slices, most GPe neurons receive a continuous inhibitory synaptic barrage from 1 or 2 presynaptic GPe neurons. We measured the barrage’s effect on the firing rate and regularity of GPe neurons in male and female mice using perforated patch recordings. Silencing the firing of parvalbumin-positive (PV+) GPe neurons by activating genetically expressed Archaerhodopsin current increased the firing rate and regularity of PV–neurons. In contrast, silencing Npas1+GPe neurons with Archaerhodopsin had insignificant effects on Npas1–neuron firing. Blocking spontaneous GABAergic synaptic input with gabazine reproduced the effects of silencing PV+neuron firing on the firing rate and regularity of Npas1+neurons and had similar effects on PV+neuron firing. To simulate the barrage, we constructed conductance waveforms for dynamic clamp based on experimentally measured inhibitory postsynaptic conductance trains from 1 or 2 unitary local connections. The resulting inhibition replicated the effect on firing seen in the intact active network in the slice. We then increased the number of unitary inputs to match estimates of local network connectivityin vivo. As few as 5 unitary inputs produced large increases in firing irregularity. The firing rate was also reduced initially, but PV+neurons exhibited a slow spike-frequency adaptation that partially restored the rate despite sustained inhibition. We conclude that the irregular firing pattern of GPe neuronsin vivois largely due to the ongoing local inhibitory synaptic barrage produced by the spontaneous firing of other GPe neurons.SIGNIFICANCE STATEMENTFunctional roles of local axon collaterals in the external globus pallidus (GPe) have remained elusive because of difficulty in isolating local inhibition from other GABAergic inputsin vivo, and in preserving the autonomous firing of GPe neurons and detecting their spontaneous local inputs in slices. We used perforated patch recordings to detect spontaneous local inputs during rhythmic firing. We found that the autonomous firing of single presynaptic GPe neurons produces inhibitory synaptic barrages that significantly alter the firing regularity of other GPe neurons. Our findings suggest that, although GPe neurons receive input from only a few other GPe neurons, each local connection has a large impact on their firing.
T cell‐dependent bispecific antibodies alter organ‐specific endothelial cell–T cell interaction
Authors: Himmels Patricia , Nguyen Thi Thu Thao , Mitzner Maresa Caunt , Arrazate Alfonso , Yeung Stacey , Burton Jeremy , Clark Robyn , Totpal Klara , Jesudason Raj , Yang Angela , Solon Margaret , Eastham Jeffrey , Modrusan Zora , Webster Joshua D , Lo Amy A , Piskol Robert , Ye Weilan 
Published: January 2023

AbstractPreclinical and clinical studies demonstrate that T cell‐dependent bispecific antibodies (TDBs) induce systemic changes in addition to tumor killing, leading to adverse events. Here, we report an in‐depth characterization of acute responses to TDBs in tumor‐bearing mice. Contrary to modest changes in tumors, rapid and substantial lymphocyte accumulation and endothelial cell (EC) activation occur around large blood vessels in normal organs including the liver. We hypothesize that organ‐specific ECs may account for the differential responses in normal tissues and tumors, and we identify a list of genes selectively upregulated by TDB in large liver vessels. Using one of the genes as an example, we demonstrate that CD9 facilitates ICAM‐1 to support T cell–EC interaction in response to soluble factors released from a TDB‐mediated cytotoxic reaction. Our results suggest that multiple factors may cooperatively promote T cell infiltration into normal organs as a secondary response to TDB‐mediated tumor killing. These data shed light on how different vascular beds respond to cancer immunotherapy and may help improve their safety and efficacy.
REINTERPRETASI HADIS KEPEMIMPIN PEREMPUAN (KRITIK HERMENEUTIKA AMINA WADUD)
Authors: Ahlan Ahlan 
Published: January 2023

Kepemimpinan perempuan di ranah publik menjadi perdebatan serius para ulama, antara lain dikalangan ulama Hadis. Perdebatan tersebut menjalar sampai pada ruang-ruang akademik, bahkan menjelma menjadi tema-tema kajian oleh beberapa peneliti. Pro-kontra atas kebolehan perempuan menjadi pemimpin terjadi hingga era modern sekarang ini. Amina Wadud dengan penafsiran Hermeneutikanya hadir membawa angin segar bagi para pengkaji perempuan. Menurut Wadud penafsiran klasik lebih menjurus kepada bias gender, dan lebih berpihak kepada laki-laki sehingga sangat tidak relevan bila diterapkan di era modern seperti sekarang ini. Wadud dengan Hermeneutikanya memaparkan bahwa penafsiran tidak hanya berhenti pada asbabul Nuzul/Asbabul Wurud sebuah dalil, atau konteks bahasanya saja, akan tetapi juga sesuai dengan kondisi dan fenomena yang terjadi pada saat ini bukan lagi melihat masa lalu. Hadis sebagai interpretasi pemikiran reformis Nabi Saw, tidak sepantasnya berindikasi bias Gender karena Hadis hadir sebagai penjelas al-Qur’an. Kesimpulan pada penelitian ini ialah dari hasil kajian Hermeneutika Wadud ditemukan sebuah poin pentingnya bahwa kepemimpian perempuan diranah publik tidak perlu dipersoalkan, karena mengingat perempuan di masa ini telah memiliki potensi yang layak bahkan melebihi laki-laki, sehingga kualitas menjadi tolak ukur boleh atau tidaknya seseorang menjadi pemimpin.
Appraisal of Clinical Care Practices for Child Obesity Treatment. Part II: Comorbidities
Authors: Skinner Asheley C. , Staiano Amanda E. , Armstrong Sarah C. , Barkin Shari L. , Hassink Sandra G. , Moore Jennifer E. , Savage Jennifer S. , Vilme Helene , Weedn Ashley E. , Liebhart Janice , Lindros Jeanne , Reilly Eileen M. 
Published: January 2023

The objective of this technical report is to provide clinicians with actionable evidence-based information upon which to make treatment decisions. In addition, this report will provide an evidence base on which to inform clinical practice guidelines for the management and treatment of overweight and obesity in children and adolescents.To this end, the goal of this report was to identify all relevant studies to answer 2 overarching key questions: (KQ1) “What are effective clinically based treatments for obesity?” and (KQ2) “What is the risk of comorbidities among children with obesity?” See Appendix 1 for the conceptual framework and a priori Key Questions.
Automated analysis of X-ray topography of 4H-SiC wafers: Image analysis, numerical computations, and artificial intelligence approaches for locating and characterizing screw dislocations
Authors: Nguyen Binh Duong , Roder Melissa , Danilewsky Andreas , Steiner Johannes , Wellmann Peter , Sandfeld Stefan 
Published: January 2023

Abstract
The physical vapor transport (PVT) crystal growth process of 4H-SiC wafers is typically accompanied by the occurrence of a large variety of defect types such as screw or edge dislocations, and basal plane dislocations. In particular, screw dislocations may have a strong negative influence on the performance of electronic devices due to the large, distorted or even hollow core of such dislocations. Therefore, analyzing and understanding these types of defects is crucial also for the production of high-quality semiconductor materials. This work uses automated image analysis to provide dislocation information for computing the stresses and strain energy of the wafer. Together with using a genetic algorithm this allows us to predict the dislocation positions, the Burgers vector magnitudes, and the most likely configuration of Burgers vector signs for the dislocations in the wafer.

Graphical abstract
Understanding oxidation of Fe-Cr-Al alloys through explainable artificial intelligence
Authors: Roy Indranil , Feng Bojun , Roychowdhury Subhrajit , Ravi Sandipp Krishnan , Umretiya Rajnikant V. , Reynolds Christopher , Ghosh Sayan , Rebak Raul B. , Hoffman Andrew 
Published: January 2023

AbstractThe oxidation resistance of FeCrAl based on alloying composition and oxidizing conditions is predicted using a combinatorial experimental and artificial intelligence approach. A neural network (NN) classification model was trained on the experimental FeCrAl dataset produced at GE Research. Furthermore, using the SHapley Additive exPlanations (SHAP) explainable artificial intelligence (XAI) tool, we explore how the NN can showcase further material insights that are unavailable directly from a black-box model. We report that high Al and Cr content forms protective oxide layer, while Mo in FeCrAl creates thick unprotective oxide scale that is vulnerable to spallation due to thermal expansion.
Graphical abstract
Tolkningens metodologi och selektiv abduktion
Authors: Matta Corrado 
Published: January 2023

I denna artikel diskuterar jag grunderna för tolkning som metodologisk ansats. Pedagogisk forskning har under lång tid gett begreppet tolkning en central metodologisk och teoretisk roll, och flera populära metoder inom pedagogik syftar till att generera tolkningar av mänskligt agerande. Jag argumenterar för två huvudsakliga teser. Enligt den första tesen är tolkningens struktur abduktiv. Enligt en vanlig konceptualisering, som härstammar från C.S. Peirces arbete, är abduktion ett resonemangsschema som innebär att man utifrån premisser bestående av en mängd observationer och en teori, härleder slutsatsen att teorin är (tentativt) sann. Den andra tesen som jag argumenterar för är att när tolkningen används som metodologiskt redskap, måste den vila på en speciell form av abduktion: selektiv abduktion. Selektiv abduktion innebär att flera hypotetiska teorier jämförs och att den teori som bäst förklarar observationerna accepteras. Jag argumenterar för att de resonemang som är typiska för tolkande ansatser i samhällsvetenskapen inte kan undvika en kontrastiv, jämförande och därmed selektiv dimension. Att tolka är i sitt väsen att jämföra. Samtidigt kritiserar jag att Peirces ursprungliga konceptualisering kan vara ett korrekt metodologiskt tillvägagångssätt för tolkning. Jag avslutar med att diskutera vissa konkreta metodologiska konsekvenser för kvalitativa metoder.