bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous assembly required: Perpetual species turnover in two‐trophic‐level ecosystems
Authors: Spaak Jurg W. , Adler Peter B. , Ellner Stephen P. 
Published: July 2023

AbstractCommunity assembly is often treated as deterministic, converging on one or at most a few possible stable endpoints. However, in nature, we typically observe continuous change in community composition, which is often ascribed to environmental change. But continuous changes in community composition can also arise in deterministic, time‐invariant community models, especially food web models. Our goal was to determine why some models produce continuous assembly and others do not. We investigated a simple two‐trophic‐level community model to show that continuous assembly is driven by the relative niche width of the trophic levels. If predators have a larger niche width than prey, community assembly converges to a stable equilibrium. Conversely, if predators have a smaller niche width than prey, then community composition never stabilizes. Evidence that food webs need not reach a stable equilibrium has important implications, as many ecological theories of community ecology based on equilibria may be difficult to apply to such food webs.
CVaR‐based method for optimizing the contract bidding strategy of PV power stations
Authors: Xu Qifeng , Qiao Songbo , Chen Mengyao , Ju Jiaxin , Li Zhiyi 
Published: July 2023

AbstractWith the rapid development of the new power system, the proportion of renewable energy participating in the electricity market is constantly increasing, and the uncertainty of renewable energy power output and market clearing price brings risks to its participation in long‐term contract bidding. Therefore, a method of contract bidding involving bidding amount and bidding price of PV power station is proposed. Firstly, the multi‐order weighted Markov chain model is used to forecast the distribution of weather states in the trading cycle, and the fuzzy C‐means (FCM) method is used to cluster the joint samples of power output indicators and market clearing price indicators, and then Latin hypercube sampling is used to generate power output scenarios and market clearing price scenarios. Then, an optimization method for long‐term contract bidding strategy of PV power station considering conditional value at risk (CVaR) and transaction probability is established, and the model is divided into two stages and solved in an alternate iterative way. Finally, an example is used to verify that the constructed model enables PV power stations to effectively avoid risks and obtain more stable revenue.
Epilepsy surgery in early infancy: A retrospective, multicenter study
Authors: Makridis Konstantin L. , Klotz Kerstin Alexandra , Ramantani Georgia , Becker Lena‐Luise , San Antonio‐Arce Victoria , Syrbe Steffen , Wagner Kathrin , Shah Mukesch Johannes , Thomale Ulrich‐Wilhelm , Tietze Anna , Elger Christian E. , Borggraefe Ingo , Kaindl Angela M. 
Published: July 2023

AbstractAlthough epilepsy surgery is the only curative therapeutic approach for lesional drug‐resistant epilepsy (DRE), there is reluctance to operate on infants due to a fear of complications. A recent meta‐analysis showed that epilepsy surgery in the first 6 months of life can achieve seizure control in about two thirds of children. However, robust data on surgical complications and postoperative cognitive development are lacking. We performed a retrospective multicenter study of infants who underwent epilepsy surgery in the first 6 months of life. 15 infants underwent epilepsy surgery at a median age of 134 days (IQR: 58) at four centers. The most common cause was malformation of cortical development, and 13 patients underwent a hemispherotomy. Two thirds required intraoperative red blood transfusions. Severe intraoperative complications occurred in two patients including death in one infant due to cardiovascular insufficiency. At a median follow‐up of 1.5 years (IQR: 1.8), 57% of patients were seizure‐free. Three patients where reoperated at a later age, resulting in 79% seizure freedom. Anti‐seizure medication could be reduced in two thirds, and all patients improved in their development. Our findings suggest that early epilepsy surgery can result in good seizure control and developmental improvement. However, given the perioperative risks, it should be performed only in specialized centers.
Fuelling the future: Assessing multifuel filling stations for hydrogen and other renewable fuels through life cycle analysis
Authors: Hjort Anders , Heyne Stefan , Fagerström Anton , Bokinge Pontus , Rootzén Johan , Jivén Karl , Nyberg Theo , Poulikidou Sofia , Lewrén Adam , Särnbratt Mirjam 
Published: July 2023

AbstractHydrogen could play an important role in reducing the climate impact of the transport sector. This study explores the possibility of using existing biomethane infrastructure to enable the accelerated roll‐out of hydrogen as a transport fuel in a Swedish context. The concept of multifuel filling stations for hydrogen and biomethane are examined based on four cases, where the hydrogen is produced either via electrolysis or biomethane reforming, at a smaller or larger scale, and through either centralised or decentralised production. The cases are compared using established life cycle assessment (LCA) methodology to establish their respective impact from a greenhouse gas (GHG) emission mitigation potential. The LCA results show generally good GHG performance for all production paths being studied with a range from −7 g CO2 eq./MJ hydrogen for hydrogen production based on biomethane via steam reformation (SMR) compared to +19 g CO2 eq. for production based on Swedish National Grid Mix via electrolyser. The SMR is the more efficient technology in mitigating GHG emissions, especially if system expansion is applied. In addition, sensitivity analyses also show that electrolyses production based on renewable wind power will decrease the impact significantly and vice versa that a European Average Electricity Grid Mix (EU – 28) would increase the impact significantly. The findings of this study underline the potential of the gradual introduction of hydrogen as a fuel for transport without the need for large investments in a dedicated fuel‐specific distribution system. The concept could contribute to overcoming the current chicken‐and‐egg catch of achieving both scalable and profitable supply of hydrogen for transport as well as the vehicles using it as fuel.
Development of a bilayer biodegradable packaging material enriched with coffee waste extract for cake preservation
Authors: Yakubu Salimata , Zheng Hui , Chen Jingwen , Amagloh Francis K. , Xu Jingge , Chen Xiaohan , Wang Li , Li Li 
Published: July 2023

AbstractThe study aimed to develop an active packaging, functionalized by spent coffee grounds extracts (SCGE) to preserve cake. The antioxidant extracts were obtained using three extraction methods: conventional extraction (CE), ultrasound‐assisted extraction (UAE), and microwave‐assisted extraction (MAE). The SCGE obtained with UAE and MAE produced the highest total phenolic contents and antioxidant activities, and were incorporated into bilayer films composed of polylactic acid, konjac glucomannan, and wheat gluten. The SCGE improved the film's antioxidant activity (8.40 to 90. 56%) and oxygen transmission rate (5.05 ± 0.04 to 2.22 ± 0.13). Active packaging with microwave extracts was more effective in preserving cake's lipids than the ultrasound extracts as measured by the peroxide value, thiobarbituric acid, and acid value during 21 days of storage. Overall, the study demonstrates the potential safe utilization of coffee waste in active packaging.
Online data service for geologic formations (Lexicons) of China, India, Vietnam and Thailand with one‐click visualizations onto East Asia plate reconstructions
Authors: Du Wen , Mishra Suyash , Ogg James G. , Qian Yuzheng , Chang Sabrina , Oberoi Karan , Ault Aaron , Zahirovic Sabin , Hou Hongfei , Raju D. S. N. , Mamallapalli O’Neil , Ogg Gabriele M. , Li Haipeng , Scotese Christopher R. , Dong Bui 
Published: July 2023

AbstractPaleogeography is the merger of sediment and volcanic facies, depositional settings, tectonic plate movements, topography, climate patterns and ecosystems through time. The construction of paleogeographic maps on tectonic plate reconstruction models requires a team effort to compile databases, data sharing standards and map projection methods. Two goals of the Paleogeography Working Group of the International Union of Geological Sciences (IUGS) program for Deep‐Time Digital Earth (DDE) are: (1) to interlink online national lexicons for all sedimentary and volcanic formations, and develop online ones for nations that currently lack these; (2) to target specific regions and intervals for testing/showcasing paleogeography output from the merger of these databases. Following those goals, we developed and applied new cloud‐based lexicon data services and interactive visualization techniques to regions in East Asia. This has been a successful collaboration among computer engineers and plate modellers and has involved stratigraphers in India (ONGC), China (Chengdu Univ. Tech., and Chinese Acad. Geol. Sci.), United States (Paleomap Project, and Purdue Univ.), Australia (GPlates visualization team) and Vietnam (Vietnam Nat. Univ.). Independent online lexicons with map‐based and stratigraphy‐based user interfaces have been developed (as of the date of this submission in March 2022) for all Proterozoic to Quaternary formations on the Indian Plate (over 800) and Vietnam (over 200), the majority of the Devonian through Neogene of China (ca. 2000) and partially for Thailand. A multi‐database search system returns all geologic formations of a desired geologic time from these four independent databases. With one click, users can plot the regional extent of one or of all of those regional formations on different plate reconstruction models of that desired age, and these polygons are filled with the lithologic facies pattern.
Endoscopic‐assisted en‐bloc pterygomaxillectomy: Identifying an efficient and safe location for the pterygoid osteotomy
Authors: García‐Lliberós Ainhoa , Martin‐Jimenez Daniel I. , Mondesir Ronsard J. , Agosti Edoardo , Alexander A. Yohan , Leonel Luciano C. P. C. , Choby Garret , Peris‐Celda Maria , Pinheiro‐Neto Carlos D. 
Published: July 2023

AbstractBackgroundFor aggressive maxillary sinus and pterygopalatine fossa (PPF) tumors, an en‐bloc pterygomaxillectomy may be indicated.MethodsFive head specimens were used to study the feasibility of an en‐bloc pterygomaxillectomy. Eighty‐five non‐pathological CT scans were used to compare the superior edge of the inferior turbinate (IT) and the middle turbinate tail (MT) as landmarks for the pterygoid osteotomy.ResultsThrough a combined sublabial–subperiosteal incision and transoral route, a mid‐sagittal osteotomy through the hard palate and an axial osteotomy below the infraorbital foramen were performed. For the endoscopic pterygoid osteotomy, an infra‐vidian transpterygoid approach was performed, subsequently removing the pterygomaxillectomy en‐bloc. As landmarks, the osteotomies at the level of the MT tail and IT resected the pterygoid plates completely, but the IT osteotomy was further away from the vidian canal (7.5 vs. 6 mm).ConclusionsThe endoscopic‐assisted en‐bloc pterygomaxillectomy is feasible. The IT landmark is safe and ensures complete resection of the pterygoid plates.
The pivotal role of HbA1c assay to detect hemoglobinopathies: A 5‐year observational retrospective study in the population of Southern France
Authors: Dupuy Anne M. , Cristol Jean P. , Bargnoux Anne S. , Plawecki Maelle , Lotierzo Manuela , Aguilar‐Martinez Patricia , Badiou Stéphanie 
Published: July 2023

AbstractBackground and AimsMobility and migration flows are growing from different countries of the world to European countries, including France and in particular the Mediterranean basin. This study aimed to investigate the presence of hemoglobin (Hb) variants in outpatients/inpatients of the Montpellier Hospital (France) in whom an HbA1c assay had been performed and for which the country of birth had been informed.MethodsThis is a retrospective study from January 2016 to December 2020 based on all high‐performance liquid chromatography (HPLC) chromatograms (Tosoh Bioscience HLC‐723G8) having an alarm of suspected Hb variant during HbA1c measurement. The corresponding samples were systematically sent to the hematology laboratory for confirmation and identification of Hb variant. Patient's medical history, clinical and demographic data were extracted from each medical chart. Statistical analyses were performed using XLSTAT® software, version 2016.06.35661.ResultsThree hundred sixty‐three patients were confirmed with Hb variant exhibiting 17 different Hb profiles, highlighting the pivotal role of glycated hemoglobin (HbA1c) as a detection step. The prevalence of Hb variant in this southern French population was 0.71%, with the highest frequency for the beta‐globin variants (n = 342/363; i.e., 94.2%), including the most common: S, C, E, and D in 200/342 (58.5%), 83/342 (24.3%), 29/342 (8.5%), and 11/342 (3.2%), respectively. Among patients with Hb variants, almost half (165/363; i.e., 45.4%) were born in the African continent with a predominance for Morocco (32/165; i.e., 19.3%) and Algeria (29/165; i.e., 17.5%).ConclusionHbA1c assay is a useful tool to detect Hb variants. Hemoglobinopathies are a public health issue in the current French population which is a multiethnic society. Despite the monocentric nature of our study, we note a high frequency of Hb variants in the south of France, which underlines the importance of screening for Hb variants in the whole population.
Pre‐K attendance and social development: The moderating role of kindergarten classroom experiences
Authors: Zimmermann Kathryn , Yang Qingqing , Purtell Kelly , Ansari Arya 
Published: July 2023

AbstractAlthough academic benefits of pre‐K are well established, the associations between pre‐K attendance and social and learning behaviours are less clear. Some research suggests that pre‐K attenders may enter and exit kindergarten exhibiting less optimal social and learning behaviours than their non‐attending peers, and little attention has been paid to how aspects of kindergarten experiences, like academic rigour, activity settings and teacher–student relationships, may contribute to these patterns of development. The current study addresses these gaps in knowledge by using nationally representative data from the ECLSK:2011 (n = 14,260) to examine the social and learning behaviours of pre‐K attenders and nonattenders at kindergarten entry and exit. Our results reveal that pre‐K attenders are not consistently underperforming their non‐attending peers on social and learning behaviours in kindergarten. However, teachers reported that pre‐K attenders exhibited more externalising behaviour problems at kindergarten entry and exit, and non‐attenders made greater gains in learning behaviours over the kindergarten year. We also found no evidence of moderation when examining our focal classroom experience variables.
New insights into the interaction between polycystic ovary syndrome and psychiatric disorders: A narrative review
Authors: Hu Runan , Geng Yuli , Huang Yanjing , Liu Zhuo , Li Fan , Dong Haoxu , Ma Wenwen , Song Kunkun , Zhang Mingmin , Zhang Zhuo , Song Yufan 
Published: July 2023

AbstractPolycystic ovary syndrome (PCOS) is a prevalent endocrine disease characterized by hyperandrogenism, ovulatory dysfunction, and ovarian polycystic changes, which combines with reproductive problems, metabolic disorders, and psychological disorders to exhibit a far‐reaching impact on the physical and mental health of women. We reviewed previous research and discovered that psychiatric disorders are more common in PCOS patients and their children, potentially exacerbating the condition and creating a vicious loop. To understand the reasons, relevant articles were collected following the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines from PubMed, Web of Science, and Cochrane Library, through December 2022. Evidence suggested that PCOS‐related clinical manifestations, hyperandrogenism, insulin resistance, obesity, gut dysbiosis, and other variables may increase the risk of psychiatric disorders in patients. In turn, psychiatric disorders may aggravate the pathologic process of PCOS and increase the difficulty of the treatment. We systematically reported the mechanisms underlying the psychiatric disorders‐PCOS interactions, intending to provide potential ways to break the vicious cycle and lay the groundwork for future research. However, research on PCOS and psychiatric disorders were still in initial stages, which limited the scope of this review. More studies are needed to further verify our findings.
Future self‐continuity and depression among college students: The role of presence of meaning and perceived social support
Authors: Xue Lulu , Yan Yun , Fan Hang , Zhang Liping , Wang Siyun , Chen Lipeng 
Published: July 2023

AbstractIntroductionFuture self‐continuity has been shown to have a protective effect against depression. This study aims to investigate the longitudinal relationship between future self‐continuity and depression among college students, and to explore the mediating role of the presence of meaning and the moderating role of perceived social support.MethodsWe conducted two studies in China in 2022 and 2023. Study 1 was a longitudinal cross‐lagged study that examined the relationship between future self‐continuity and depression among 173 participants (49.13% females, Mage = 19.39, SD = 1.63). Study 2 was a cross‐sectional study that explored the mediating role of the presence of meaning and the moderating role of perceived social support among 426 participants (48.59% females, Mage = 19.30, SD = 1.60).ResultsStudy 1 showed that future self‐continuity (T1) could significantly predict depression (T2), but depression (T1) could not predict future self‐continuity (T2). Study 2 showed that after controlling for gender, the presence of meaning mediated the relationship between future self‐continuity and depression, whereas perceived social support moderated the first half of the mediated model's pathway and the direct pathway.ConclusionsThese findings suggest that enhancing the future self‐continuity of college students and increasing the level of presence of meaning are effective measures for alleviating depression. Meanwhile, educators and families are called upon to provide more social support to college students.
A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice
Authors: Wang Xuejun , McKillop William M. , Dlugi Theresa A. , Faber Mary L. , Alvarez‐Argote Juliana , Chambers Christopher B. , Wilber Andrew , Medin Jeffrey A. 
Published: July 2023

AbstractSickle cell disease (SCD) results from a sequence defect in the β‐globin chain of adult hemoglobin (HbA) leading to expression of sickle hemoglobin (HbS). It is traditionally diagnosed by cellulose‐acetate hemoglobin electrophoresis or high‐performance liquid chromatography. While clinically useful, these methods have both sensitivity and specificity limitations. We developed a novel mass spectrometry (MS) method for the rapid, sensitive and highly quantitative detection of endogenous human β‐globin and sickle hβ‐globin, as well as lentiviral‐encoded therapeutic hβAS3‐globin in cultured cells and small quantities of mouse peripheral blood. The MS methods were used to phenotype homozygous HbA (AA), heterozygous HbA–HbS (AS) and homozygous HbS (SS) Townes SCD mice and detect lentiviral vector‐encoded hβAS3‐globin in transduced mouse erythroid cell cultures and transduced human CD34+ cells after erythroid differentiation. hβAS3‐globin was also detected in peripheral blood 6 weeks post‐transplant of transduced Townes SS bone marrow cells into syngeneic Townes SS mice and persisted for over 20 weeks post‐transplant. As several genome‐editing and gene therapy approaches for severe hemoglobin disorders are currently in clinical trials, this MS method will be useful for patient assessment before treatment and during follow‐up.
Metabolism‐related gene vaccines and immune infiltration in ovarian cancer: A novel risk score model of machine learning
Authors: Fu Yiyuan , Huang Zheng , Huang Jiezhen , Xiong Jian , Liu Huishu , Wan Xiaoyan 
Published: July 2023

AbstractBackgroundThe present study aims to develop a metabolic gene signature to evaluate the survival rate of ovarian cancer (OC) patients and analyze the potential mechanisms of metabolic genes in OC because the difficulty in early detection of OC often leads to poor treatment outcomes.MethodsA non‐negative matrix factorization algorithm was applied to determine molecular subtypes according to metabolism genes. To build a risk prognosis model, least absolute shrinkage and selection operator multivariate Cox analysis was carried out with weighted correlation network analysis (WCGNA). Glycolytic flux and mitochondrial function were evaluated by conducting seahorse analysis.ResultsOn the basis of metabolism‐related genes, the two subtypes of OC samples present in The Cancer Genome Atlas database were distinguished. An analysis of WGCNA identified 1056 genes. Lastly, a 10‐gene signature (CMAS, ADH1B, PLA2G2D, BHMT, CACNA1C, AADAC, ALOX12, CYP2R1, SCN1B and ME1) was constructed that demonstrated promising performance in predicting outcome in patients with OC. The RiskScore of the gene signature was linked to microenvironment cell infiltration and immune checkpoint. Higher RiskScores were associated with poorer results for OC patients. Seahorse analysis shows the influence of CMAS in cell energy metabolism.ConclusionsIn the present study, a novel marker for evaluating the survival of OC patients was developed through the creation of a gene signature incorporating metabolism‐related genes. Our knowledge of immunotherapy and microenvironment cell infiltration may be enriched by evaluating metabolism‐related gene modification patterns.
Heart failure‐induced brain myelin changes and differences between sexes
Authors: Roy Bhaswati , Vacas Susana , Ehlert Luke , Townsley Madeline , Carrier Megan , Fonarow Gregg C. , Woo Mary A. , Kumar Rajesh 
Published: July 2023

AbstractHeart failure (HF) leads to brain injury in autonomic, respiratory, mood, and cognitive control sites, revealed as tissue volume loss, altered metabolites, and impaired diffusion tissue properties. The extent of myelin changes in HF and variations within sexes are unclear. Our aim was to examine regional brain subcortical and white matter myelin integrity in HF patients over control subjects, as well as differences between sexes using T1‐ and T2‐weighted clinical images. We acquired T1‐ and T2‐weighted images from 63 HF patients and 129 controls using a 3.0‐Tesla MRI scanner. Using T1‐ and T2‐weighted images, ratio maps were computed, normalized to a common space, smoothed, and compared between groups (ANCOVA; covariates: age and sex; SPM12, false discovery rate, p < .010), as well as between male versus female HF (ANCOVA; covariate: age; SPM12, uncorrected p < .005). Multiple brain areas in HF showed decreased myelin integrity, including the amygdala, hippocampus, cingulate, insula, cerebellum, prefrontal cortices, and multiple white matter areas, compared to controls. Female HF patients showed more brain injuries in the parietal, prefrontal and frontal, hippocampus, amygdala, pons, cerebellar, insula, and corpus callosum compared to male HF patients. HF subjects showed compromised subcortical and white matter myelin integrity, especially in sites regulating autonomic, respiratory, mood, and cognition, with more changes in females over males. These findings provide a structural basis for the enhanced symptoms identified in female over male HF patients with similar disease severity.