bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staging of colorectal cancer using lipid biomarkers and machine learning
Authors: Krishnan Sanduru Thamarai , Winkler David , Creek Darren , Anderson Dovile , Kirana Chandra , Maddern Guy J , Fenix Kevin , Hauben Ehud , Rudd David , Voelcker Nicolas Hans 
Published: September 2023

Abstract
Introduction
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. Alteration in lipid metabolism and chemokine expression are considered hallmark characteristics of malignant progression and metastasis of CRC. Validated diagnostic and prognostic biomarkers are urgently needed to define molecular heterogeneous CRC clinical stages and subtypes, as liver dominant metastasis has poor survival outcomes.

Objectives
The aim of this study was to integrate lipid changes, concentrations of chemokines, such as platelet factor 4 and interleukin 8, and gene marker status measured in plasma samples, with clinical features from patients at different CRC stages or who had progressed to stage-IV colorectal liver metastasis (CLM).

Methods
High-resolution liquid chromatography-mass spectrometry (HR-LC-MS) was used to determine the levels of candidate lipid biomarkers in each CRC patient’s preoperative plasma samples and combined with chemokine, gene and clinical data. Machine learning models were then trained using known clinical outcomes to select biomarker combinations that best classify CRC stage and group.

Results
Bayesian neural net and multilinear regression-machine learning identified candidate biomarkers that classify CRC (stages I-III), CLM patients and control subjects (cancer-free or patients with polyps/diverticulitis), showing that integrating specific lipid signatures and chemokines (platelet factor-4 and interluken-8; IL-8) can improve prognostic accuracy. Gene marker status could contribute to disease prediction, but requires ubiquitous testing in clinical cohorts.

Conclusion
Our findings demonstrate that correlating multiple disease related features with lipid changes could improve CRC prognosis. The identified signatures could be used as reference biomarkers to predict CRC prognosis and classify stages, and monitor therapeutic intervention.
Pathogenicity of Phytophthora and Halophytophthora species on black alder and the host histological response
Authors: Vieites-Blanco Cristina , Colangelo Michele , Camarero J. Julio , Caballol Maria , García Breijo Francisco José , Štraus Dora , Oliva Jonàs 
Published: September 2023

AbstractRiparian alder forests are threatened by Phytophthora across Europe. Comparative studies of the pathogenicity of Phytophthora species are crucial for developing effective management strategies. Although only a limited number of species, particularly P. × alni, lead to tree decline in natural environments, many species demonstrate pathogenicity in inoculation trials. Phytophthora species vary in their ability to infect different tissues, such as phloem and xylem, and trigger defence responses in the host through the formation of tyloses and callose. By comparing the histological responses of alder to various Phytophthora species, we can gain insights into the success of P. × alni and the potential damage that could be caused by other species. To investigate the defence strategies of black alder (Alnus glutinosa) against attack by Phytophthora and Halophytophthora species present in Catalonia (NE Spain), we conducted inoculation trials on saplings using nine potentially pathogenic species and compared the histological responses. Phytophthora × alni and P. plurivora were the most aggressive species followed by other exotic species such as P. × cambivora and P. cactorum. Phytophthora × alni and P. plurivora were equally damaging despite the higher prevalence of P. × alni in declining alders in natural settings. Although P. × alni mainly invaded the phloem, P. plurivora also invaded the xylem and triggered the production of tyloses. Histological analyses revealed a diverse range of plant responses to infection by Phytophthora species, providing a better understanding of their adaptability in natural environments compared with solely observing lesions. The low level of callose production in saplings inoculated with P. × alni compared with callose production in saplings inoculated with less pathogenic species suggests that P. × alni can evade recognition by the host and, hence, could partially explain its success.
Dependence in constrained Bayesian optimization
Authors: Zhang Shiqiang , Lee Robert M. , Shafei Behrang , Walz David , Misener Ruth 
Published: September 2023

AbstractConstrained Bayesian optimization optimizes a black-box objective function subject to black-box constraints. For simplicity, most existing works assume that multiple constraints are independent. To ask, when and how does dependence between constraints help?, we remove this assumption and implement probability of feasibility with dependence (Dep-PoF) by applying multiple output Gaussian processes (MOGPs) as surrogate models and using expectation propagation to approximate the probabilities. We compare Dep-PoF and the independent version PoF. We propose two new acquisition functions incorporating Dep-PoF and test them on synthetic and practical benchmarks. Our results are largely negative: incorporating dependence between the constraints does not help much. Empirically, incorporating dependence between constraints may be useful if: (i) the solution is on the boundary of the feasible region(s) or (ii) the feasible set is very small. When these conditions are satisfied, the predictive covariance matrix from the MOGP may be poorly approximated by a diagonal matrix and the off-diagonal matrix elements may become important. Dep-PoF may apply to settings where (i) the constraints and their dependence are totally unknown and (ii) experiments are so expensive that any slightly better Bayesian optimization procedure is preferred. But, in most cases, Dep-PoF is indistinguishable from PoF.
Preserved Muscle Strength Despite Muscle Mass Loss After Bariatric Metabolic Surgery: a Systematic Review and Meta-analysis
Authors: Jung Han Na , Kim Seon-Ok , Jung Chang Hee , Lee Woo Je , Kim Myung Jin , Cho Yun Kyung 
Published: September 2023

Abstract
Background
Contrary to the previously known concept of muscle mass decrease following bariatric metabolic surgery, changes in muscle strength have been poorly investigated in systematic reviews. In this meta-analysis, we evaluated changes in handgrip strength (HGS) and lean mass (LM) after undergoing bariatric metabolic surgery.

Methods
A systematic literature review using the PubMed, Embase, and Cochrane Library databases was conducted in November 2022. Longitudinal studies reporting HGS change after bariatric metabolic surgery were eligible. Pooled estimates for changes in HGS, body mass index (BMI), LM, and fat mass (FM) were calculated. Changes from baseline to the point closest to 6 months postoperatively were analyzed in trials with multiple follow-up examinations. The risk of bias was assessed using the Joanna Briggs Institute critical appraisal checklist.

Results
Three randomized controlled trials and seven prospective cohort studies involving 301 patients were included. Follow-up evaluations were conducted 6 months postoperatively in all trials except for two, whose follow-up visits were at 18 weeks and 12 months, respectively. Pooled analysis showed reduced BMI (− 10.8 kg/m2; 95% confidence interval: − 11.6 to − 9.9 kg/m2), LM (− 7.4 kg; − 9.3 to − 5.4 kg), and FM (− 22.3 kg; − 25.1 to − 19.6 kg) after bariatric metabolic surgery, whereas the change in HGS was not statistically significant (− 0.46 kg; − 1.76 to 0.84 kg).

Conclusion
Despite the decreased body composition parameters, including muscle mass, strength was not impaired after bariatric metabolic surgery; this indicates that bariatric metabolic surgery is an effective weight management intervention that does not compromise strength.

Graphical Abstract
Workplace Interventions for Type 2 Diabetes Mellitus Prevention—an Umbrella Review
Authors: Wnuk Katarzyna , Świtalski Jakub , Tatara Tomasz , Miazga Wojciech , Jopek Sylwia , Augustynowicz Anna , Religioni Urszula , Gujski Mariusz 
Published: September 2023

Abstract
Purpose of review
Type 2 diabetes mellitus (T2DM) is a chronic disease that may lead to severe complications. The main methods of preventing or delaying the onset of T2DM include lifestyle changes. The purpose of this study is to identify and evaluate the effectiveness of workplace interventions aimed at preventing type 2 diabetes. An umbrella review was conducted in accordance with the Cochrane Collaboration guidelines. Searches were performed in Medline (via PubMed), Embase (via OVID), and Cochrane Library databases. The quality assessment of the included studies was performed using the AMSTAR2 tool.

Recent findings
The final analysis included 7 studies. The majority (4 of 7) of the studies included in the review focused on workplace interventions based on the guidelines of the US Diabetes Prevention Program (DPP) or other similar programs. The method of decreasing the risk of type 2 diabetes among employees are programs consisting of multiple approaches aimed at improving parameters associated with diabetes, i.e., body weight, and therefore BMI, reduction, and reducing blood glucose levels, as well as HbA1c levels through educational approach and lifestyle changes. The results of those studies point to multicomponent interventions as more effective than single-component interventions.

Summary
An effective workplace intervention aimed to reduce the risk of type 2 diabetes among employees is a multicomponent program consisting of elements such as educational activities, interventions targeting dietary changes and increased physical activity.
Effects of Dietary Valine Chelated Zinc Supplementation on Growth Performance, Antioxidant Capacity, Immunity, and Intestine Health in Weaned Piglets
Authors: Zhang Tuan , Zhang Nan , Peng Shuyu , Zhang Yawei , Wang Huakai , Huang Shiyu , Zhu Min , Ma Yongxi 
Published: September 2023

AbstractThis study was conducted to investigate the effects of dietary valine chelated zinc (ZnVal) supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets. A total of 240 healthy 35-day-old weaned piglets (Duroc × Landrace × Yorkshire, average weight 10.70 ± 0.14 kg) were randomly divided into five groups with six replicate pens and eight piglets per pen. Dietary treatments were a corn–soybean meal basal diet supplemented with 0, 25, 50, 75, and 100 mg/kg ZnVal, respectively. The experiment lasted for 28 days. Results showed that average daily gain (ADG) was increased (P < 0.05) by ZnVal with 75–100 mg/kg supplementation on days 15–28 and with 50–100 mg/kg supplementation on days 1–28. Supplementation of 25–100 mg/kg ZnVal reduced (P < 0.01) the diarrhea rate of weaned piglets on days 1 to 14 and 1 to 28. Dietary supplementation with 25–100 mg/kg ZnVal increased (P < 0.05) copper/zinc-superoxide dismutase (Cu/Zn-SOD) and decreased malonaldehyde (MDA) activities in the serum on day 14 and 28. Supplementation of 25–100 mg/kg ZnVal increased (P < 0.05) glutathione peroxidase (GSH-Px) activity in serum on day 14. Additionally, the supplementation of 75 mg/kg ZnVal significantly increased the activity of superoxide dismutase (SOD) and Cu/Zn-SOD in the liver (P < 0.05). Furthermore, the supplementation of 25–100 mg/kg ZnVal significantly increased the total antioxidant capacity (T-AOC) in the liver (P < 0.05). Higher (P < 0.05) concentrations of IgG in the serum were measured from piglets supplemented with 75–100 mg/kg ZnVal on day 14 and dietary supplementation with 25–100 mg/kg ZnVal increased the level of immunoglobulin G (IgG) in serum on day 28 (P < 0.05). In addition, higher (P < 0.05) concentrations of immunoglobulin A (IgA) in the duodenum and ileum were measured from piglets supplemented with 75 mg/kg ZnVal and the supplementation of 25–100 mg/kg ZnVal also showed a higher (P < 0.05) concentration of immunoglobulin G (IgG) in duodenum. Supplementation of 50–100 mg/kg ZnVal increased the villus height and villus height/crypt depth of jejunum (P < 0.05). Moreover, dietary supplementation with 75–100 mg/kg ZnVal showed a higher (P < 0.05) concentration of zinc in the liver and supplementation of 50–100 mg/kg ZnVal increased (P < 0.05) the concentration of zinc in the heart, spleen, and kidney. In conclusion, the present research showed that supplementation of ZnVal improves growth performance by increasing antioxidant capacity and immunity and regulating intestinal morphology and the optimal inclusion level of ZnVal was 65~80 mg/kg.
Contact Endoscopic Surface Vascular and Epithelial Morphology in Leukoplakia and Carcinoma of the Vocal Cords
Authors: Pavlidis Pavlos , Tseriotis Vasileios Spyridon , Matthias Christopher , Katsikari Ioulia , Chatzinikolaou Aimilios , Gouveris Haralampos 
Published: September 2023

AbstractPurpose Leukoplakia is a macroscopic morphological term for thick white or grey mucosal patches that can represent various histologic diagnostic entities ranging from hyperplasia to malignancy. Aim was the study morphology of the superficial mucosa and microvascular network of the vocal cords in patients with suspected glottic squamous cell carcinoma (SCC) using contact endoscopy (CE). Material and Methods Seventy-nine patients (21 female, 58 male), with a mean age of 57.5 years ± 7.12 (range, 32–73 years), were prospectively enrolled and evaluated. Of these patients, 58 had leukoplakia (Group A/41 males and 17 females, with a mean age of 53.7 years ± 6.65), and 21 (Group B/ 17males and 4 females/ with a mean age of 60.5 years ± 6.04) had malignant lesions (pT1, n = 6; p T2, n = 8; pT3, n = 8; Group B), as proven by the results of the histological examination. Further, 79 non-smokers (control group—group C) were studied. CE imaging findings were classified into five types (I to V) based on the features of the mucosal intra-epithelial capillary loops. CE findings were correlated to the histologic findings. A separate analysis involving smoking status was done. Results The CE-based intraepithelial papillary capillary loop classification score was strongly correlated with the histological findings. Age was strongly associated with both malignancy and bilateral involvement. Smoking habits didn’t significantly differ between patients with unilateral and bilateral SCC. Conclusions CE imaging of the vocal cord mucosal capillaries may be useful for the early detection of glottic SCC and pre-cancerous lesions.
Health anxiety and oppressive support: their impact on decisions for non-urgent use of the emergency department of obstetrics and gynecology
Authors: Mazzoni Davide , Amadori Roberta , Sebri Valeria , Tosi Marco , Pregnolato Sara , Surico Daniela , Pravettoni Gabriella 
Published: September 2023

AbstractThe high number of non-urgent visits to the emergency departments of obstetrics and gynecology (EDOG) is receiving increasing attention from researchers and public health professionals. The decision to access the EDOG is the result of a decision-making process based on three phases, from the problem recognition to the intention to seek medical care, and the decision to visit the EDOG. Each stage may depend on different psychological and social factors, but their specific role is still unclear. The aim of this study was to investigate the psychological and social factors which are implied in the decision-making process leading to non-urgent visits to the emergency department. A questionnaire was administered to 280 women between the 10th and the 14th week of pregnancy. Results showed that health anxiety had a positive effect on all three stages of the decision-making process (problem recognition, seeking medical care, and visiting the emergency department). Satisfaction with the prenatal care service showed a positive effect on the first two stages, while oppressive support had a positive effect on visiting the emergency department. We suggest that educational interventions for patients and family members aimed at reducing health anxiety and oppressive support during pregnancy could reduce the number of inappropriate accesses to the emergency department, with a beneficial effect on its functioning, patient-and-caregiver relationship, and the healthcare system costs.
Patient Expectations and Satisfaction in Pediatric Orthopedics
Authors: Cazzulino Alejandro , Bach Katherine , Cordero Rafael , Swarup Ishaan 
Published: September 2023

Abstract
Purpose of Review
The purpose of the current review is to analyze the current literature regarding the tools available to evaluate patient expectations and satisfaction. There have been an increasing number of tools that have been developed and validated for various orthopedic procedures. Despite the growing number of tools, there are a limited number of tools available for pediatric patients.

Recent Findings
Several tools have been developed in orthopedics to evaluate patient expectations. However, there are no tools that have been validated in the pediatric population. In addition, pediatric patient expectations should be collected in conjunction with parent/caregiver expectations. Although not specifically validated for pediatric patients, there are several tools available that may pertain to pediatric patients including the HSS ACL Expectations Survey, HSS Shoulder Expectations Survey, HSS Knee Surgery Expectations Survey, HSS Foot and Ankle Surgery Expectation Survey, Sunnybrook Surgery Expectations Survey, Musculoskeletal Outcomes Data Evaluation and Management System (MODEMS) Instruments, Quick DASH, and DASH.
In terms of patient satisfaction, there are even fewer tools available. Several tools have been developed to evaluate patient satisfaction and five additional tools within orthopedics. Of these tools, there are two that have been validated for pediatric patients: The Swedish Parents Satisfaction Questionnaire and the Scoliosis Research Society-22.

Summary
There are a growing number of tools to evaluate patient’s expectations and satisfaction in the orthopedic literature. Given most of these tools pertain to adult patients, there is a need for further development of tools specifically validated for pediatric patients and their parents/caregivers. Through the measurement of expectations and satisfaction, medical professionals can hope to improve satisfaction and outcomes.
Printed Circuit Boards Leaching Followed by Synthesis of Gold Nanoparticle Clusters Using Plant Extracts
Authors: Nobahar Amir , Lourenço João Paulo , Costa Maria Clara , Carlier Jorge Dias 
Published: September 2023

AbstractThis work investigates the potential of 70% ethanolic leaf extracts of Rubus idaeus L., Cistus ladanifer L. and Erica andevalensis in the metal separation from synthetic unimetallic solutions of different metals and a leachate obtained from the leaching of PCBs. Results from the experiments with unimetallic solutions revealed R. idaeus and E. andevalensis extracts induced separation of more than 95% of the initial Au(III), while C. ladanifer separated ~78% of this metal. Thereafter, application of three plant extracts to real Au bearing leachate obtained from PCBs leaching, revealed about 96, 95 and 90% Au recovery with R. idaeus, C. ladanifer and E. andevalensis extracts, respectively with 15–60% co-removal of Pb and less than 15% of other metals. The reduction of Au(III) ions into Au(0) nanoparticles by R. idaeus extract was confirmed by molecular UV–Visible, and FT-IR analysis showed the involvement of plant secondary metabolites in Au bio-reduction and bio-stabilization. Particles obtained from the application of R. idaeus extract to the leachate were initially analyzed with XRD and results confirmed the presence of Au(0) with contamination of PbSO4, which was completely removed by washing with 1 M HCl. Thereafter, results from STEM-EDS analysis showed the presence of Au particles conjugated with organic material and other metals. Consequently, particles were subjected to another washing step with acetone. Afterwards, STEM-EDS showed pure Au microparticle clusters (~0.8 μm) with flower-shaped or apparently cubic morphologies, and HRSTEM showed the tiny nanoparticles (~20 nm), which form the clusters.
Graphical Abstract
Two global quasi-Newton algorithms for solving matrix polynomial equations
Authors: Macías Mauricio , Pérez Rosana , Martínez Héctor Jairo 
Published: September 2023

AbstractIn this article, we globalize the quasi-Newton algorithm proposed in Macías et al. (Appl Math Comput 441:127678, 2023) introducing an exact line search, we propose a polynomial approximation to the merit function and we deduce a sufficient condition for its minimization interval. We use the exact merit function and its approximation to propose two global quasi-Newton algorithms for solving matrix polynomial equations. For each algorithm, we prove that the exact line search does not affect the convergence of quasi-Newton method. In addition, we present comparative numerical tests of the algorithmic proposals in which we also compare with global Newton’s method.
Modulo 2 congruences for partitions with initial repetitions
Authors: Nyirenda Darlison , Mugwangwavari Beaullah 
Published: September 2023

AbstractMotivated by Andrews’ partitions with initial repetitions, we derive parity formulas for several functions for this class of partitions. In many cases, we present an infinite family of Ramanujan-type congruences modulo 2.
Criteria for Assessing the Sustainability of Logging Operations—A Systematic Review
Authors: Grünberg Julian , Ghaffariyan Mohammad Reza , Jourgholami Meghdad , Labelle Eric R. , Kaakkurivaara Nopparat , Robert Renato Cesar Gonçalves , Kühmaier Martin 
Published: September 2023

Abstract
Purpose of Review
The comprehensive assessment of timber and fuelwood harvesting operations through the consideration of the three pillars of sustainability: Economic, social, and environmental has not received much attention. The use of criteria can significantly improve impact assessment. Therefore, the objective of this review paper is to compile and analyze the most commonly used criteria and indicators for each dimension of sustainability in logging operations over the last 6 years. This review provides an overview of these criteria for different harvesting machines, geographical areas, slope classes, time periods, types of research, and silvicultural treatments.

Recent Findings
The environmental pillar was the most studied (46%), followed by the economic pillar (38%). Productivity was the most investigated criterion (15%). On the one hand, productivity is linked to the environmental and social pillars, as it is related to the level of greenhouse gas emissions, energy consumption, and the employment rate. However, productivity is mainly used as a criterion of financial interest, as it is most often studied in combination with costs. In addition to productivity, the other most frequently examined criteria were costs (10%), soil nutrients (9.5%), and soil compaction (9%). The social dimension was the least studied pillar (16%). This may be due to a lack of knowledge of social sustainability issues in this area.

Summary
Sustainability is achieved when all three dimensions are balanced. The results of this review show an imbalance, with economic and environmental aspects being weighted more heavily than social aspects. Balancing all three dimensions typically requires an assessment of trade-offs. This review provides a comprehensive summary of the criteria that have been studied to date and can be used as a checklist and guideline for future sustainability assessments of harvesting operations.