bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a model that supports the evolution of legacy systems into an enterprise
Authors: Terry Sian , Chandrasekar V. 
Published: June 2023

AbstractThis article details the first step in the system dynamics analysis of the systems engineering process for the evolution of legacy systems into an enterprise. This step develops a model that depicts the interaction of the various components associated with the system of interest. This model is a collection of causal loop diagrams that will foster the development of a novel framework known as the enterprise lifecycle model, which will support system dynamics analysis through three stages: planning, development, and execution. Peer‐reviewed academic and industry sources will be utilized to understand how accepted literature defines this analysis. Specifically, this model will be based on the Vee lifecycle model as well as the Agile and Iron Triangle frameworks. Supplemental elements will be added to these diagrams to incorporate the environment within which the system of interest is planned, developed, and executed. Additional factors, such as quality management, will be added to complete the super system and system of interest views of the enterprise lifecycle model—with the goal of creating a model depicting a reductive and holistic view that aids in the reduction of complexity surrounding the systems engineering process used to prepare legacy systems for evolution into an enterprise and support the definition of the desired target system.
ROS‐mediated PERK‐CHOP pathway plays an important role in cadmium‐induced HepG2 cells apoptosis
Authors: Zhaohui Cao , Cifei Tang , Di Huang , Weijia Zeng , Cairui Han , Zecong Li , Xiaobo Hu 
Published: June 2023

AbstractCadmium (Cd) is a common heavy metal that is highly toxic to the liver, however, the exact mechanism underlying this damage accompanied by apoptosis has not been thoroughly demonstrated. In this study, we found that Cd exposure significantly reduced cell viability, including the increased populations of apoptotic cells and caspase‐3/‐7/‐12 activation in HepG2 cells. Mechanistically, Cd initiated oxidative stress via elevating reactive oxygen species (ROS) levels, leading to oxidative damage in HepG2 cells. Simultaneously, Cd exposure induced endoplasmic reticulum (ER) stress via activating the protein kinase RNA‐like ER kinase (PERK)‐C/EBP homologous protein (CHOP) axis in HepG2 cells, and subsequently disturbed ER function as increased Ca2+ releasing from ER lumen. Intriguingly, further study revealed that oxidative stress is closely related with ER stress, as pretreatment with ROS scavenger, N‐acetyl‐l‐cysteine (NAC) markedly reduced ER stress as well as protected ER function in Cd treated HepG2 cell. Collectively, these findings first revealed Cd exposure induced HepG2 cells death via a ROS‐mediated PERK‐CHOP‐related apoptotic signaling pathway, which provides a novel insight into the mechanisms of Cd‐induced hepatotoxicity. Furthermore, inhibitors for oxidative stress and ER stress might be considered as a new strategy to prevent or treat this disorder.
The new non‐centrosymmetric zinc borate Zn2B10O17 with a unique crystal structure
Authors: Ziegler Raimund , Purtscher Felix R. S. , Bayarjargal Lkhamsuren , Hofer Thomas S. , Huppertz Hubert 
Published: June 2023

AbstractThe novel zinc borate Zn2B10O17 was synthesized under high‐pressure/high‐temperature conditions of 8 GPa and 1573 K in a multianvil apparatus. Single‐crystal X‐ray diffraction revealed a unique crystal structure that crystallizes in the orthorhombic non‐centrosymmetric space group Pmc21 (no. 26) with a=769.15(2), b=711.14(2), c=822.14(2) pm, V=0.450(1) nm3 and two formula units (Z=2) per unit cell. The crystal structure is discussed, SHG measurements, and theoretical calculations at HSEsol level of theory were carried out. Herein, we reported about the novel zinc borate Zn2B10O17. It is synthesizable via high‐pressure/high‐temperature solid state reactions and features a unique crystal structure in the non‐centrosymmetric space group Pmc21 (no. 26), which was confirmed by a SHG‐measurement. The structure of Zn2B10O17 consists of an anionic borate framework, that is formed solely by (BO4) units. The zinc atoms are located in channels along the a‐axis and are tetrahedrally and octahedrally coordinated by oxygen atoms. The crystal structure was confirmed by MAPLE, CHARDI, and BL/BS calculations. Furthermore, theoretical calculations at HSEsol level were performed to obtain insight into the band structure properties and the DOS of the zinc borate. Zn2B10O17 is a colourless, ionic compound with a wide band gap of 8.4 eV and is therefore categorized as insulator.
Fazit
Authors: Rakers Marius 
Published: June 2023

ZusammenfassungIm Laufe dieser Arbeit wurde wiederholt deutlich, dass es sich bei der SEPA-Echtzeitüberweisung um eine Sonderform der regulären Überweisung handelt. Der Rechtsrahmen der SEPA Instant Payments ergänzt in seiner Struktur die zur Standard-Überweisung bestehenden Vorschriften. Die Besonderheiten der jederzeitigen Erreichbarkeit, der verkürzten Ausführungsfrist und der Möglichkeit des nachgelagerten Clearings und Settlements wurden über die Regelungen des SICT Rulebooks und der SB EÜ in die verschiedenen Vertragsverhältnisse übertragen.
Renormalon subtraction in OPE by dual space approach: nonlinear sigma model and QCD
Authors: Hayashi Yuuki , Mishima Go , Sumino Yukinari , HiromasaTakaura  
Published: June 2023

Abstract
It is becoming more important to subtract renormalons efficiently from perturbative calculations, in order to achieve high precision QCD calculations. We propose a new framework “Dual Space Approach” for renormalon separation, which enables subtraction of multiple renormalons simultaneously. Using a dual transform which suppresses infrared renormalons, we derive a one-parameter integral representation of a general observable. We investigate systematically how renormalons emerge and get canceled in the entire operator product expansion (OPE) of an observable, by applying the expansion-by-regions (EBR) method to this one-parameter integral expression. In particular we investigate in detail OPEs in a solvable model, the 2-dimensional O(N) nonlinear σ model, by the dual space approach. A nontrivial mechanism of renormalon cancellation in this model can be understood from an integration identity on which the EBR method is founded. We demonstrate that the dual space approach can be useful by a simulation study imitating the QCD case. Application of this method to QCD calculations is also discussed.
Fake Z
Authors: Dymarsky Anatoly , Kalloor Rohit R. 
Published: June 2023

Abstract
Recently introduced connections between quantum codes and Narain CFTs provide a simple ansatz to express a modular-invariant function $$ Z\left(\tau, \overline{\tau}\right) $$
Z

τ

τ
¯

in terms of a multivariate polynomial satisfying certain additional properties. These properties include algebraic identities, which ensure modular invariance of $$ Z\left(\tau, \overline{\tau}\right) $$
Z

τ

τ
¯

, and positivity and integrality of coefficients, which imply positivity and integrality of the 𝔲(1)n × 𝔲(1)n character expansion of $$ Z\left(\tau, \overline{\tau}\right) $$
Z

τ

τ
¯

. Such polynomials come naturally from codes, in the sense that each code of a certain type gives rise to the so-called enumerator polynomial, which automatically satisfies all necessary properties, while the resulting $$ Z\left(\tau, \overline{\tau}\right) $$
Z

τ

τ
¯

is the partition function of the code CFT — the Narain theory unambiguously constructed from the code. Yet there are also “fake” polynomials satisfying all necessary properties, that are not associated with any code. They lead to $$ Z\left(\tau, \overline{\tau}\right) $$
Z

τ

τ
¯

satisfying all modular bootstrap constraints (modular invariance and positivity and integrality of character expansion), but whether they are partition functions of any actual CFT is unclear. We consider the group of the six simplest fake polynomials and denounce the corresponding Z’s as fake: we show that none of them is the torus partition function of any Narain theory. Moreover, four of them are not partition functions of any unitary 2d CFT; our analysis for other two is inconclusive. Our findings point to an obvious limitation of the modular bootstrap approach: not every solution of the full set of torus modular bootstrap constraints is due to an actual CFT. In the paper we consider six simple examples, keeping in mind that thousands more can be constructed.
On the IR/UV flavour connection in non-universal axion models
Authors: Di Luzio Luca , Guerrera Alfredo Walter Mario , Díaz Xavier Ponce , Rigolin Stefano 
Published: June 2023

Abstract
Non-universal axion models, with the Peccei-Quinn (PQ) symmetry acting on Standard Model (SM) fermions in a generation-dependent way, are typically accompanied by two different sources of flavour violation, dubbed here as infrared (IR) and ultraviolet (UV). The former is due to the flavour violating axion couplings to SM fermions, while the latter arises from the heavy degrees of freedom that UV complete the axion effective field theory. We point out that these two sources of flavour violation are directly related and exemplify this connection in a general class of non-universal axion model, based on a renormalizable DFSZ-like setup with two Higgs doublets (PQ-2HDM). We next discuss the interplay of axion flavour phenomenology with the signatures stemming from the heavy radial modes of the PQ-2HDM, including meson oscillation observables and charged lepton flavour violating decays. We emphasize the strong complementarity between flavour observables, LHC direct searches and standard axion physics.
Seismic Waveform Tomography for 3D Impedance Model with Salt Structure
Authors: Gao Fengxia , Wang Yanghua 
Published: June 2023

AbstractConventional impedance inversion from post-stack zero-offset seismic data is usually based on the convolution model, and wave-equation based inversion is rarely used, although it is capable to precisely describe seismic wave propagation and invert impedance model with higher resolution. That is because there are more than one physical parameters involved in the conventional wave equation, making impedance inversion complicated. In this study, a one-dimensional (1D) wave equation, containing only the impedance parameter, is adopted and applied for the inversion of 1D impedance model by seismic waveform tomography. However, for a three-dimensional (3D) model, direct application of the 1D waveform tomography may lead to lateral discontinuities. Therefore, we propose to utilize a truncated Fourier series to parameterize the 3D impedance model, and then invert for the Fourier coefficients. With this parameterization scheme, the large- and small-scale components of the impedance model can be reconstructed stepwise by gradually increasing the number of Fourier coefficients. To efficiently and effectively invert the coefficients for the 3D model with salt structure, we propose a joint strategy, in which the low-frequency seismic data is used to invert for the Fourier coefficients representing the large-scale components of the model, while the high-frequency seismic data is applied to invert for the Fourier coefficients representing the small-scale components of the model. Tests on a 3D impedance model with salt structure result in models with high resolution and good spatial continuity, proving the feasibility and stability of the impedance inversion procedure.
Proximal bone block with distal screw trajectory improves mechanical stability during distalization tibial tubercle osteotomy
Authors: Uppstrom Tyler J. , Cash Brian M. , Jahandar Amirhossein , Fletcher Connor , Nguyen Joseph T. , Maher Suzanne A. , Strickland Sabrina M. , Gomoll Andreas H. 
Published: June 2023

AbstractPurposeThe purpose of this study was to quantify differences in mechanical stability of a wedge‐shaped distalization tibial tubercle osteotomy (TTO) with a standard technique, versus a modified technique with use of a proximal bone block and distally angled screw trajectory.MethodsTen fresh‐frozen cadaver lower extremity specimens (five matched pairs) were utilized. Within each specimen pair, one specimen was randomly assigned to undergo a standard distalization osteotomy fixed with two bicortical 4.5‐mm screws oriented perpendicular to the long axis of the tibia, and the other to undergo a distalization osteotomy with modified fixation utilizing a proximal bone block and distally angled screw trajectory. Each specimen’s patella and tibia were mounted on a servo‐hydraulic load frame using custom fixtures (MTS Instron). The patellar tendon was dynamically loaded to 400 N at a rate of 200 N/second for 500 cycles. Following the cyclic loading, loading to failure was done at 25 mm/min.ResultsThe modified distalization TTO technique demonstrated significantly higher average load to failure compared to the standard distalization TTO technique (1339 N vs. 844.1 N, p < 0.001). Average maximum tibial tubercle displacement during cyclic loading was significantly smaller in the modified TTO technique group compared to the standard TTO technique (1.1 mm vs. 4.7 mm, p < 0.001).ConclusionThis study demonstrates that distalization TTO utilizing a modified technique with a proximal bone block and distally aimed screws is biomechanically superior to standard distalization TTO without proximal bone block and screw trajectory perpendicular to the long axis of the tibia. This increased stability may aid in reducing the reported higher complication rates (including loss of fixation, delayed union and nonunion) following distalization TTO, although future clinical outcome studies are warranted.
Validation of quantitative assessment of florbetaben PET scans as an adjunct to the visual assessment across 15 software methods
Authors: Jovalekic Aleksandar , Roé-Vellvé Núria , Koglin Norman , Quintana Mariana Lagos , Nelson Aaron , Diemling Markus , Lilja Johan , Gómez-González Juan Pablo , Doré Vincent , Bourgeat Pierrick , Whittington Alex , Gunn Roger , Stephens Andrew W. , Bullich Santiago 
Published: June 2023

AbstractPurposeAmyloid positron emission tomography (PET) with [18F]florbetaben (FBB) is an established tool for detecting Aβ deposition in the brain in vivo based on visual assessment of PET scans. Quantitative measures are commonly used in the research context and allow continuous measurement of amyloid burden. The aim of this study was to demonstrate the robustness of FBB PET quantification.MethodsThis is a retrospective analysis of FBB PET images from 589 subjects. PET scans were quantified with 15 analytical methods using nine software packages (MIMneuro, Hermes BRASS, Neurocloud, Neurology Toolkit, statistical parametric mapping (SPM8), PMOD Neuro, CapAIBL, non-negative matrix factorization (NMF), AmyloidIQ) that used several metrics to estimate Aβ load (SUVR, centiloid, amyloid load, and amyloid index). Six analytical methods reported centiloid (MIMneuro, standard centiloid, Neurology Toolkit, SPM8 (PET only), CapAIBL, NMF). All results were quality controlled.ResultsThe mean sensitivity, specificity, and accuracy were 96.1 ± 1.6%, 96.9 ± 1.0%, and 96.4 ± 1.1%, respectively, for all quantitative methods tested when compared to histopathology, where available. The mean percentage of agreement between binary quantitative assessment across all 15 methods and visual majority assessment was 92.4 ± 1.5%. Assessments of reliability, correlation analyses, and comparisons across software packages showed excellent performance and consistent results between analytical methods.ConclusionThis study demonstrated that quantitative methods using both CE marked software and other widely available processing tools provided comparable results to visual assessments of FBB PET scans. Software quantification methods, such as centiloid analysis, can complement visual assessment of FBB PET images and could be used in the future for identification of early amyloid deposition, monitoring disease progression and treatment effectiveness.
Impact of extramedullary disease in AML patients undergoing sequential RIC for HLA-matched transplantation: occurrence, risk factors, relapse patterns, and outcome
Authors: Fraccaroli Alessia , Vogt Daniela , Rothmayer Margarete , Spiekermann Karsten , Pastore Friederike , Tischer Johanna 
Published: June 2023

Abstract
We sought to evaluate the role of extramedullary disease (EMD) in sequential RIC retrospectively analyzing data of 144 high-risk AML patients undergoing HLA-matched transplantation. Median long-term follow-up was 11.6 years. Eighteen percent of patients (n = 26/144) presented with extramedullary AML (EM AML) or a history of EMD at time of transplantation. Overall relapse rate was 25% (n = 36/144) with 15% (n = 21/144) of all patients developing isolated BM relapse and 10% (n = 15/144) developing EM AML relapse with or without concomitant BM relapse (EM ± BM). Manifestation of EM relapse after transplantation occurred frequently at multiple sites and presented mostly as solid tumor mass. Only 3/15 patients with EM ± BM relapse showed a prior EMD manifestation. EMD prior to allogeneic transplantation had no impact on post-transplant OS when compared to non-EMD (median post-transplant OS 3.8 years versus 4.8 years; ns). Risk factors (p =  < 0.1) for EM ± BM relapse included younger age and a higher number of prior intensive chemotherapies, whereas the presence of chronic GVHD was a protective factor. Median post-transplant OS (15.5 months vs. 15.5 months), RFS (9.6 months vs 7.3 months), and post-relapse OS (6.7 months vs. 6.3 months) were not significantly different between patients with isolated BM vs. EM ± BM relapse. Taken together, occurrence of EMD prior to as well as of EM ± BM AML relapse after transplantation was moderate, presenting mostly as solid tumor mass after transplantation. However, diagnosis of those does not seem to influence outcomes after sequential RIC. A higher number of chemotherapy cycles prior to transplantation was identified as recent risk factor for EM ± BM relapse.
Early initiation of second-line therapy in primary immune thrombocytopenia: insights from real-world evidence
Authors: Cuker Adam , Buckley Brian , Mousseau Marie-Catherine , Barve Aditya Anand , Haenig Jens , Bussel James B. 
Published: June 2023

AbstractTo compare patients with primary immune thrombocytopenia (ITP) prescribed early (within 3 months of initial ITP treatment) second-line treatment (eltrombopag, romiplostim, rituximab, immunosuppressive agents, splenectomy) with or without concomitant first-line therapy to those who received only first-line therapy. This real-world retrospective cohort study of 8268 patients with primary ITP from a large US-based database (Optum® de-identified Electronic Health Record [EHR] dataset) combined electronic claims and EHR data. Outcomes included platelet count, bleeding events, and corticosteroid exposure 3 to 6 months after initial treatment. Baseline platelet counts were lower in patients receiving early second-line therapy (10‒28 × 109/L) versus those who did not (67 × 109/L). Counts improved and bleeding events decreased from baseline in all treatment groups 3 to 6 months after the start of therapy. Among the very few patients for whom follow-up treatment data were available (n = 94), corticosteroid use was reduced during the 3- to 6-month follow-up period in patients who received early second-line therapy versus those who did not (39% vs 87%, p < 0.001). Early second-line treatment was prescribed for more severe cases of ITP and appeared to be associated with improved platelet counts and bleeding outcomes 3 to 6 months after initial therapy. Early second-line therapy also appeared to reduce corticosteroid use after 3 months, although the small number of patients with follow-up data on treatment precludes any substantive conclusions. Further research is needed to determine whether early second-line therapy has an effect on the long-term course of ITP.
Wound healing potential of sodium alginate-based topical gels loaded with a combination of essential oils, iron oxide nanoparticles and tranexamic acid
Authors: Nqoro X. , Adeyemi S. A. , Ubanako P. , Ndinteh D. T. , Kumar P. , Choonara Y. E. , Aderibigbe B. A. 
Published: June 2023

AbstractWound management is a key feature in saving people’s lives, and regardless of the wound size, using appropriate wound dressing is crucial. Alginate-based topical gels loaded with 2 mL essential oils (eucalyptus, lavender and rosemary oil) in combination with 30 mg magnetite (Fe3O4) nanoparticles and 70 mg tranexamic acid were prepared. Carbopol was used as a gelling agent and as a surfactant to disperse the EO. X-ray diffraction (XRD) and scanning electron microscope (SEM) confirmed the successful formation of Fe3O4 nanoparticles. The Fourier transform infrared spectroscopy revealed the absence of a chemical interaction between the iron nanoparticles, tranexamic acid, essential oils and the gel matrix. The gel formulations displayed pH, spreadability and viscosity in the range of 6.8–7.2, 5.4–10.1 cm and viscosity (3444–1260 cp) after 120 s, respectively. The in vitro wound healing studies of the wound dressings revealed a wound closure of 99% on day 3. Their antibacterial and blood clotting potential was significant compared to the control. The wound healing capability of these formulations makes them potential wound dressings for treating bleeding and infected wounds.
Balneotherapy for osteoarthritis: a systematic review
Authors: Protano Carmela , Fontana Mario , De Giorgi Andrea , Marotta Daniela , Cocomello Nicholas , Crucianelli Serena , Del Cimmuto Angela , Vitali Matteo 
Published: June 2023

AbstractThis systematic review is aimed to evaluate the effects of balneotherapy with thermal mineral water for managing the symptoms and signs of osteoarthritis located at any anatomical site. The systematic review was conducted according to the PRISMA Statement. The following databases were consulted: PubMed, Scopus, Web of Science, Cochrane Library, DOAJ and PEDro. We included clinical trials evaluating the effects of balneotherapy as a treatment for patients with osteoarthritis, published in English and Italian language, led on human subjects. The protocol was registered in PROSPERO. Overall, 17 studies have been included in the review. All of these studies were performed on adults or elderly patients suffering from osteoarthritis localized to knees, hips, hands or lumbar spine. The treatment assessed was always the balneotherapy with thermal mineral water. The outcomes evaluated were pain, palpation/pressure sensibility, articular tenderness, functional ability, quality of life, mobility, deambulation, ability to climb stairs, medical objective and patients’ subjective evaluation, superoxide dismutase enzyme activity, serum levels of interleukin-2 receptors. The results of all the included studies agree and demonstrated an improvement of all the symptoms and signs investigated. In particular, pain and quality of life were the main symptoms evaluated and both improved after the treatment with thermal water in all the studies included in the review. These effects can be attributed to physical and chemical-physical properties of thermal mineral water used. However, the quality of many studies resulted not so high due and, consequently, it is necessary to perform new clinical trial in this field using more correct methods for conducting the study and for processing statistical data.