bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of material resources in vocabulary explanations: a conversation analytic inquiry
Authors: Koç Tuncay , Ergül Hatice 
Published: January 2023

Abstract
Recent studies have examined the interactional management of verbal and non-verbal vocabulary explanations in second language (L2) classrooms. However, the use of material resources in vocabulary explanations has not been fully investigated yet. Based on a corpus of fourteen class-hours of (50-min each) video recordings of an L2 Oral Communication classroom at a higher education setting in Turkey, this study explores how material resources are employed in vocabulary explanation sequences in combination with talk and gestures. Using the micro-analytic lens of multimodal Conversation Analysis (CA) for the examination of the detailed transcriptions of vocabulary explanation sequences with material resources, three different patterns were identified: (1) gesture + material resources; (2) talk + gesture + material resources; and (3) scene enactment + material resources. The findings of this study contribute to classroom interaction research, more specifically to studies on vocabulary teaching, by providing a micro-analytic account of how material resources are employed in vocabulary explanations.
A Novel Inpatient Buprenorphine Induction Program for Adolescents With Opioid Use Disorder
Authors: Trope Lee A. , Stemmle Monica , Chang Annie , Bashiri Nasrin , Bazazi Alexander R. , Lightfoot Marguerita , Congdon Jayme L. 
Published: January 2023

BACKGROUND
Morbidity and mortality from nonprescribed opioid use and opioid use disorder (OUD) in adolescents have risen dramatically. Medication for opioid use disorder (MOUD) with buprenorphine reduces nonprescribed opioid use and prevents overdoses, though &lt;5% of adolescents with OUD have timely access, partly because of barriers associated with buprenorphine induction. Induction in an inpatient pediatric setting has the potential to address such barriers and improve adolescent MOUD access.

METHODS
We developed and implemented a protocol for inpatient buprenorphine induction and linkage to MOUD care within a safety-net health system. After 1 year, we conducted descriptive analysis of participant characteristics, rates of induction completion and treatment linkage, and adverse events. We analyzed field notes from multidisciplinary huddles to identify implementation facilitators and barriers.

RESULTS
During May 2021 to July 2022, we completed 46 admissions for 36 patients aged 12 to 21 years. All used fentanyl and no other opioids. Forty of 46 (87%) admissions resulted in completed induction, and 3 additional patients never developed withdrawal symptoms and were discharged with maintenance buprenorphine. Linkage to ongoing treatment occurred within 2 weeks for 31 of 43 (72%) admissions for which buprenorphine was started. We identified facilitators and barriers to program implementation and maintenance.

CONCLUSION
These results provide promising preliminary evidence of the feasibility of inpatient buprenorphine induction for adolescents with OUD. Given the public health urgency and severe shortage of adolescent access to MOUD, these results prompt consideration of broader clinical implementation and research to facilitate rapid expansion of access to evidence-based OUD care.
Editorial
Authors: Villa Villa Sandra 
Published: January 2023

Antes de compartir el recorrido de la edición N° 38 de la revista, quisiera agradecer por todas las muestras de afecto y reconocimiento que hemos recibido por parte de la comunidad académica. Cada edición llega con energías renovadas, enfrentados a desafíos cada vez mayores, y con la certeza de ir afianzándonos como una revista de gran calidad y a la vanguardia en los temas que interesan a docentes, estudiantes y a los lectores en general.
Recordando los inicios de este sueño, de editar una revista, en la que fuera posible plasmar el quehacer académico de profesores, que día a día buscan inquietamente, mostrar la evolución desde los diferentes temas que abordan, donde plasman sus ideas y aportan el conocimiento adquirido con el paso del tiempo; hoy podemos afirmar que hemos consolidado el sueño inicial.
La escritura como medio de trasmisión del conocimiento
Authors: Castillo Hernández José Andrés 
Published: January 2023

Escribir como acto es el ajuste a las circunstancias específicas tomando en cuenta el espacio, el contexto, la temporalidad, el conocimiento sobre el tema, el lenguaje y las formas de vida, esto repercute en la investigación, organización, la planeación del texto y la reescritura del documento, y sobre todo a quien va dirigido este texto. Los sistemas educativos identifican a la educación básica como obligatoria contemplando las etapas de desarrollo del niño podemos decir, que el aprendizaje no puede limitarse lo que se debe hacer es preparar a los individuos para vivir en un mundo de constante trasformación. La necesidad de buscar nuevas vías y planteamientos para formar el currículo escolar, la razón es que los contenidos y las competencias deben incorporarse a fin de lograr un aprendizaje significativo en el estudiante uno de los temas de gran impacto en la educación ha sido el uso de Tecnologías de Información y Comunicación (TIC) no solo el alumno también el docente se ha visto inmenso e influenciado por los múltiples cambios que se han presentado, los nuevos escenarios, la didáctica y el diseño de materiales que permitan desarrollar el proceso Enseñanza-Aprendizaje (E-A) de las personas; educar dentro de un marco de cultura digital, los aspectos pedagógicos, directamente en la didáctica hacer un cambio en las prácticas educativas y en los procesos de E-A, evitando llegar a un desvanecimiento del sentido de la educación el cual afecta por igual al para qué, al qué y al cómo del sentido de la educación.
Intra-articular steroid using lor technique in managing frozen shoulder
Authors: Sharma Saksham , Agrawal Yogesh Kumar , Pachori Sachin , Sharma Abhinav 
Published: January 2023

Frozen shoulder a condition very commonly encountered in Orthopaedics OPD with multiple variable treatment options. The study was done to infer out the efficacy of intraatricular steroid in shoulder joint in managing frozen shoulder.study encompassed 28 female patients, coming in Orthopaedics OPD of RBM Hospital and medical College, Bharatpur, Rajasthan.30 min post procedure 22 patients gained significant range of motion of shoulder with minimal pain. 24 patients completed their follow up of 6 weeks with significant overhead abduction and rotation.4 patients had limited rotationIntra atricular steroid injections in managing frozen shoulder is a cost effective, simple and safe method with clinical evaluation to exclude tendinopathy and radiography to exclude glenohumeral arthritis a mainstay before procedure.
Academic Integrity in Higher Educational Institutions in Times of the Covid-19 Pandemic: World Experience and Ukrainian Realities
Authors: Duliba Yevheniia , Petroye Olha , Pletsan Khrystyna , Havryliuk Alla , Antonenko Volodymyr , Antonova Olena 
Published: January 2023

Distance learning and online evaluation created challenges for academic integrity because academic dishonesty has become widespread. The article deals with actual problems of observance of academic integrity in higher educational institutions in Ukraine generally and during the transition to online training.
Analysis of divergent world’s rankings is demonstrated the close interrelation among the quality of educational system and total level of economic welfare and prosperity of the country, where academic integrity is a primary indicator of the quality of education. Today Ukraine has a lot of actual problems of observance of academic integrity in higher educational institutions generally and during the transition to online learning. Based on the world experience of observance of academic integrity, Ukraine needs profound transformational change. Results demonstrated that it is necessary to form a new policy-making of academic integrity and a new culture in universities in Ukraine, where the dedication of academic integrity should become fundamentally important for any open and democratic society. Higher educational institutions should bear primary responsibility for maintaining academic integrity in the academic society, perform their main assignments effectively, and each participant should be given a certain role, rights, obligations and responsibility.
Opening Pandora's box: Climate change, COVID-19 and the rise of a new pandemic
Authors: Mohamed Farzahna , Mokgoko Didintle , Zamparini Jarrod , Naidoo Vivendra Aroomugam , Murray Lyle , Diana Nina , Kalla Ismail 
Published: January 2023

Abstract
Climate change presents an evolving global healthcare crisis having both direct and indirect impacts on communicable and non-communicable diseases. Rapidly changing climatic conditions and extreme weather events promote the transmission of airborne, waterborne, foodborne, and vector-borne pathogens. Emergence of novel pathogens pose a greater threat to humanity. Several individual pathogens have been documented to cause infectious disease in humans are directly exacerbated by environmental hazards. There is a close interplay between climate change, pathogen virulence, spread and host related factors including susceptibility to more severe disease. The direct link between COVID-19 and climate change is unclear. Due to the recent onset and progression of the pandemic, much is still to be learnt on long-term effects of climate change on COVID-19. The central theme from the COVID-19 crisis was the similarity shared by COVID-19 and climate change on the effect on global microeconomic fundamentals. This should serve as a reality check for the revision of our global climate policy, with its neglect coming at an extremely high cost. COVID-19 allows us a glimpse of what we as society may be faced with in the future if we neglect the adverse effects of climate change.
Concept for development of economically alloyed ausferritic (bainitic) ductile cast irons
Authors: Pokrovsky A. I. 
Published: January 2023

The distribution of the castings production in the world, whose total output is more than 112 million tons, is considered. A steady trend to the replacement of rolled alloy steel, which is used for critical engineering products, by Austempered Ductile Iron (ADI) is outlined. The latter is ductile cast iron with globular graphite, which is austempered (isothermally quenched) to produce ausferritic (bainitic) structure. The dynamics of prices for main alloying elements in ADI (molybdenum, nickel and copper, whose total amount in the alloy reaches 5 %) is considered and their steady growth is outlined.The research goal is to develop a concept of economical alloying of ADI (the total content of Mo, Ni and Cu should not exceed 2 %) retaining sufficient hardenability and substantially decreasing the cost price. The goal is attained by decreasing the content of the most expensive alloying element, molybdenum, to a minimal level along with the use of microalloying and applying one of the methods of hot plastic deformation to the casting.The reduced content of the main ‘triad’ of alloying elements is compensated by microadditives of strontium or barium, vanadium, boron, niobium and the addition of misch metal. Several groups of economically alloyed cast irons are proposed: (1) low‑nickel and low‑molybdenum with increased content of copper (up to 1.8 %) and the addition of vanadium, (2) molybdenum‑free with microadditive of boron, (3) molybdenum‑free with microadditives of niobium and boron, and (4) molybdenum‑free minimally alloyed with nickel and copper.It is shown that plastic deformation, along with giving the product the required shape, affects the kinetics of structural‑phase transformations. and acts similarly to alloying with Mo and Ni, shifting the TTT‑curve to the right. Therefore, the ausferritic structure can be obtained at a lower cooling rate.The mechanical properties with such alloying and the use of plastic deformation are the following: ultimate tensile strength 1100–1500 MPa and elongation to failure 2–4 % for lower bainite; ultimate tensile strength 800–1100 MPa and elongation to failure is 4–7 % for upper bainite.
The effect of Etanercept therapy on adrenal steroid metabolism in juvenile idiopathic arthritis: a steroid metabolomics approach
Authors: Aviel Yonatan Butbul , Keinan Ariel , Hartmann Michaela F. , Wudy Stefan A. , Tiosano Dov 
Published: January 2023

Abstract
Objective: To evaluate the impact of anti-tumor necrosis factor-alpha (TNFα: etanercept [Etanercept ®]) therapy on adrenal activity in juvenile idiopathic arthritis (JIA) .
Method: Eleven JIA patients aged 12±6.2 years with a disease duration of 6.3±5.2 years were enrolled. They were treated once weekly with etanercept (0.8 mg/kg) for 3±2.8 years. Urine samples for gas chromatography-mass spectrometry steroid hormone analysis were collected before, and 1 and 3 days after etanercept injection and compared to age- and sex-matched healthy controls.
Results: The levels of 21 of the 31 metabolites were low before etanercept treatment. Those 21 metabolites included 4 C19 steroids (androgens), 5 C C21 steroid hormone intermediates, 10 cortisol metabolites, and 2 corticosterone metabolites. One day after treatment, only 5 of the 21 metabolite levels remained low. They included 2 C19 metabolites, 2 C21 steroid metabolites and 1 cortisol metabolite β –Cortol (β-Cl). Three days after treatment, the only metabolites levels that continued to be low were 2 C19 metabolite, 2 C21 steroid hormone intermediates and 1 cortisol metabolite α-Cortol (a-Cl), while the remaining 15 metabolites had already normalized after 1 day. Dehydroepiandrosterone-sulfate and 17-hydroxypregnenolone metabolite levels were the last ones to recover. Urinary metabolite ratios reflecting cytochrome P450 CYP21A2 (21-hydroxylase) and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzymatic activities were lower in JIA patients than in controls, although significant was not reached.
Conclusion: Almost all of the pre-etanercept treatment cortisol urinary metabolite levels were significantly lower than normal, and almost all rose to normal values by 1 day after treatment. The therapeutic effect of anti-TNFα treatment in JIA may be related to its effect on the restoration of adrenal function and cortisol levels.
Mathematical Model for the Quantification of Pulmonary and Intrapulmonary Arteriovenous Anastomoses Blood Flow
Authors: Vanni Rosalba 
Published: January 2023

Abstract

Background and Objectives: Accurately quantifying blood flow through a shunt vessel is vitally important, because shunt prevents gas exchange and can provide a pathway for emboli to bypass the pulmonary microcirculation. Some current techniques allow only an approximate estimate of the pulmonary shunt and present technical-evaluation difficulties that can compromise the result.
To overcome the technical-evaluation problems and obtain an accurate detection of the pulmonary blood flow
(Qp) and intrapulmonary arteriovenous anastomoses (QIPAVA), it is necessary to find and isolate the fundamental parameters of gas exchange associated with chemical-physical laws that regulate them, develop a specific algebraic-analytical model and subsequently validate it by entering some experimental data.
Methods: Elaboration of nine literal equations designed similarly to physics formulas of universal application. Some experimental data were entered to validate them.
Results: Qp and QIPAVA were detected at rest, moderate (50% of VO2max) and heavy exercise (≥90% of VO2max)
both in normoxia (FIO2= 0.2093) and acute hypoxia (FIO2= 0.125).
In normoxia under heavy exercise, Qp decreased slightly (97.56% of Qt), and QIPAVA represented 2.44% of Qt.
Instead, in hypoxia at heavy exercise, Qp decreased significantly (85.25% of Qt), and QIPAVA increased significantly (14.75% of Qt).
It was possible to demonstrate a negative contribution of QIPAVA directly to gas exchange efficiency and identify incorrect Qt measurements.
Conclusions: These equations are precise and of universal application. They describe the real phenomenon of gas exchange for each individual.
Qp differs significantly from Qt under some physiological conditions already in healthy subjects.
The use of this model will allow research a general advance in the understanding of this critical biological function and in clinical practice a precise and early detection of the pathology.
Stillbirth and Its Association with Early rupture of Membranes in Sub-Saharan Africa: Systematic Review and Meta-Analysis
Authors: Yezengaw Telksew Yelma , Dingeta Tariku , Assebe Tesfaye , Tusa Biruk Shalmeno 
Published: January 2023

Abstract
Background
Stillbirth rate is an important indicator of access to quality antenatal and delivery care services. Many previous pocket studies were conducted to assess the magnitude of stillbirth and its association with premature rupture of membrane. However, the level of stillbirth, as well as its relationship with premature rupture of membrane (PROM), varies from study to study. This systematic review and meta-analysis was conducted to estimate the pooled prevalence of stillbirth and its association with the early rupture of membranes in sub-Saharan Africa.
Method
Electronic databases such as PubMed Central PMC, Cochrane library, Medline via Virtual Health Library (VHL), HINARI (Health Inter Network Access to Research Initiative) portal, and Google scholar were used for searching for original articles. The heterogeneity of the studies was checked by I-squared statistics. A Random-effects method was applied to estimate the pooled prevalence of stillbirth and the effect size of the early rupture of membranes in sub-Saharan Africa. Subgroup analysis was performed based on region (East, West, Central, and Southern Africa) and year of study (before 2015 and after 2015). A funnel plot and Egger’s regression test was used to see publication bias.
Result
Pooled prevalence of stillbirth in sub-Saharan Africa was 6.4% (95% CI: 5.5–7.3). In sub-group analysis, Southern African regions had a higher stillbirth prevalence and the western African regions had a lower than East and Southern Africa. The prevalence of stillbirth in the region is increased from 4.1% (95% CI: 2.2–6.0) before 2015 to 7.1% (95% CI: 5.8–8.3) after 2015. The pooled odds ratio results from seven studies showed the non-significant effect of early rupture of membrane on stillbirth (pooled OR = 1.54, 95% CI: 0.26–2.82). According to the regression test (Egger test), there was no small study effects or publication bias (P = 0.108).
Conclusions
The pooled prevalence of stillbirth in sub-Saharan Africa was relativity high. The analysis establishes the minimal effects of early rupture of membrane on stillbirth. Therefore, we recommend that strengthening the testing intervention is crucial to reduce the still relatively high stillbirths.
Upper body compression wear improves muscle oxygenation following intense video game training: a randomized cross-over study among competitive gamers
Authors: DiFrancisco-Donoghue Joanne , Rothstein Alexander , Jung Min-Kyung , Zwibel Hallie , Werner William G 
Published: January 2023

Abstract
Esport players require a high number of action moves per minute to play with substantial contractions of the wrist extensor muscles. Players frequently suffer from acute fatigue. The purpose of this study was to examine the use of below the elbow compression sleeves on Sm02 during intense aim training. Secondly, to examine players’ performance and perception with and without compression. Methods This study was conducted at the New York Institute of Technology and enrolled fifteen collegiate esport players, 2 women and 13 men (age 21.2 ± 2.2). All subjects signed written consent. Participants performed 3 high intensity bouts of an aim trainer followed by a 15-minute rest before doing another 3 bouts of high intensity training conducting the other arm. The compression wear order was randomized. The primary outcome included Sm02 of the extensor carpi radialis longus using near-infrared spectrometry. Secondary outcomes included Kills Per Second (KPS), Score, Total Time to Kill (TTK), accuracy, and perceived performance. Results Following 15 minutes of recovery, there was a significant rise in Sm02 while wearing the compression sleeve compared to no compression sleeve (p = 0.004). No change in Sm02 was seen while gaming. In trials 1 and 2, wearing the compression sleeve resulted in a significant increase in KPS and score when compared to not wearing it (p = 0.002,0.006). Although TTK and accuracy did not alter, 46.7% of participants believed the compression sleeve aided their performance. Conclusions This study provides support that wearing below the elbow upper body compression sleeves while performing high intensity gaming may reduce fatigue, improve muscle recovery and gaming performance. Trial registration: Clinicaltrials.gov identifier NCT05037071. Registered September 8, 2021, URL: Arm Compression on Muscle Oxygen Saturation - Full Text View - ClinicalTrials.gov
Blood-brain barrier disruption in Long COVID-associated cognitive impairment
Authors: Greene Chris , Connolly Ruairi , Brennan Declan , Laffan Aoife , O'Keeffe Eoin , Zaporojan Lilia , Connolly Emma , Cheallaigh Cliona Ni , Conlon Niall , Doherty Colin , Campbell Matthew 
Published: January 2023

Abstract
Vascular disruption has been heavily implicated in COVID-19 pathogenesis and may predispose the neurological sequelae associated with the condition now known as long COVID. To date, no studies have objectively assessed blood-brain barrier (BBB) function in individuals with neurological complications stemming from prior SARS-CoV-2 infection. Here, we explored the neurobiological effects of SARS-CoV-2 infection in humans with acute infection (n = 76) and those with persistent long COVID with and without neurological impairment. Following acute infection, patients with neurological impairment had increased serum S100β, indicative of BBB disruption. Furthermore, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in long COVID patients (n = 32), we observed elevated BBB permeability in distinct neuroanatomical regions including the frontal cortex, occipital lobe and temporal lobes which correlated with global brain volume and white matter volume deficits in patients with neurological impairment. Patients with neurological impairment had increased levels of blood-based biomarkers including GFAP, TGFβ and IL8 with levels of TGFβ that correlated with BBB permeability and structural brain changes. Peripheral blood mononuclear cells isolated from unaffected and long COVID patients had persistent upregulation of inflammatory markers including IFNA/G and showed increased adhesion to human brain endothelial cells in vitro. Finally, exposure of endothelial cells to serum from long COVID patients induced increases in ICAM-1, VCAM-1 and TNF irrespective of neurological sequelae. Together, these data suggest that sustained systemic inflammation and persistent localised BBB dysfunction is a feature of long COVID-associated neurological impairment. Importantly, this may also be therapeutically relevant in the treatment and clinical management of this patient group.