bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of attached gingiva space color according to gender and age in Caucasian population
Authors: Naranjo María J. , Gómez‐Polo Miguel , Gómez‐Polo Cristina , Celemin‐Viñuela Alicia 
Published: March 2023

AbstractObjectiveTo describe the color of the healthy attached gingiva adjacent to the maxillary incisors and to evaluate the effect of age and gender on CIELAB color coordinates.Materials and MethodsThe study included 216 Caucasian individuals (129 females and 87 males) divided into three age groups. A SpectroShade Micro spectrophotometer was used to register color coordinates at 2.5 mm apical of the zenith of the upper central incisors. Descriptive and inferential statistical analysis was performed.ResultsThe minimum and maximum coordinates in which the CIELAB natural gingival space is delimited are: L* minimum 40.4 ‐ L* maximum 61.2; a* minimum 17.0 ‐ a* maximum 30.2; b* minimum 9.8 ‐ and b* maximum 21.9. There are statistically significant differences between males and females for coordinates L*, a* and b* in the attached gingival area selected. Age had a significant effect on coordinate b* (p = 0.000).ConclusionsStatistically significant differences were found between the L*, a* and b* color coordinates of the attached gingiva between men and women, although the color difference is below the clinical acceptance threshold. The attached gingiva takes on a bluish color as the patients get older, which means that the b* coordinate decreases.Clinical SignificanceWith a prosthodontic approach, knowledge of the CIELAB natural attached gingival coordinates based on the patient's age and gender will facilitate the clinician's work in selecting the appropriate color. The CIELAB system values found can be used as a gingival shade guide reference.
Using social exchange theory to examine relationship processes in asexual‐allosexual couples
Authors: Clark Alyssa N. 
Published: March 2023

AbstractI use social exchange theory to contextualize relationship processes associated with relationship stability in asexual‐allosexual couples and to propose directions for future research. Social exchange theory suggests that asexual‐allosexual couples might experience varied relationship exchanges compared to other relationship types based on costs/benefits, equity, and available alternatives. These exchanges may also be influenced by differences in relationship commitment and power. I review literature on sexual desire, sexual frequency, willingness to engage in sexual behavior, asexual identity acceptance, and extradyadic behavior to examine how these relationship processes are associated with relationship maintenance for asexual‐allosexual couples. Such relationship processes are not necessarily unique to asexual‐allosexual couples, but partner expectations may be particularly different in asexual‐allosexual couples, thus altering their relationship exchanges. Further research may provide a nuanced understanding of asexual‐allosexual relationship maintenance, and recommendations for how to promote healthy interactions and relationship satisfaction in asexual‐allosexual couples.
Protecting seriously ill populations during pragmatic clinical trials
Authors: Teno Joan M. , Hanson Laura C. , Lima Julie C. , Saliba Debra 
Published: March 2023

AbstractPragmatic clinical trials (PCTs) emphasize real‐world effectiveness methodology to address the limitations of results from explanatory randomized clinical trials (RCTs), which often fail to translate to real‐world medical practice. An inherent tension in the conduct of PCTs is that the research must impose a minimal burden on patients and health care institutions. PCTs prioritize outcome measures from existing data sources to minimize data collection burden; however, a lack of patient‐reported outcomes may result in gaps in safety for vulnerable populations, such as those with serious illnesses. One proposed standard for judging the readiness of a study for a pragmatic trial is a ranking system that assigns PCTs a lower rank if they impose additional data collection burdens. However, this results in the wide use of measures of health care utilization and costs while patient experience measures, which could capture adverse unintended consequences, are omitted. In this article, we make the case for a risk‐based approach to imposing additional data collection in PCTs to capture potential safety and patient experience outcomes, using examples from “real life” implemented interventions to improve end‐of‐life care through the Liverpool Pathway and through the implementation of Physician Orders for Life Sustaining Treatment (POLST) in Oregon.
Long‐term follow‐up outcomes of laser‐treated port wine stain patients: A double‐blinded retrospective study
Authors: Lekwuttikarn Ramrada , Pimsiri Anansiripun , Somsak Tanrattanakorn 
Published: March 2023

AbstractBackgroundPort wine stains (PWS) can be effectively treated with lasers. However, complete clearance is rarely observed, and data from long‐term studies are limited. The study aimed to evaluate the efficacy and complications of long‐term laser treatment in patients with PWS.MethodsWe performed a 25‐year double‐blinded retrospective chart review of patients diagnosed with PWS who underwent laser treatment at Ramathibodi Hospital, Thailand, between June 1995 and June 2021. The scores for improvement and color were independently evaluated by two dermatologists.ResultsA total of 129 patients were included. Most patients were male (70.54%). A total of 4141 laser treatment sessions were reviewed, with a median of 49 (interquartile range, 27–66) sessions per patient. A total of 1070 photographic records were reviewed. Overall, 53% of the patients achieved statistically significant (50%) improvement, after six treatment sessions. However, none of these patients achieved complete clearance. Due to the nonuniform treatments, we could not evaluate the efficacy of each laser type. However, this study illustrates the outcomes of a real‐world setting in which various laser types were selected specifically for each patient to obtain the best result.ConclusionsVascular lasers are a promising treatment for PWS. Although laser treatment is applicable to most patients, multiple treatment sessions are required to achieve excellent results.
Classic heat stroke in a desert climate: A systematic review of 2632 cases
Authors: Yezli Saber , Yassin Yara , Ghallab Sujoud , Abdullah Mashan , Abuyassin Bisher , Vishwakarma Ramesh , Bouchama Abderrezak 
Published: March 2023

AbstractBackgroundAlthough classic heat stroke (HS) is one of the most ancient conditions known to humans, the description of its early clinical manifestations, natural course, and complications remains uncertain.ObjectivesA systematic review of the demographics, clinical characteristics, biomarkers, therapy, and outcomes of HS during the Muslim (Hajj) pilgrimage in the desert climate of Mecca, Saudi Arabia.MethodsWe searched the MEDLINE, Embase, Web of Science Core Collection, SCOPUS, and CINAHL databases from inception to April 2022. We summarized the data from eligible studies and synthesized them in narrative form using pooled descriptive statistics.ResultsForty‐four studies, including 2632 patients with HS, met the inclusion criteria. Overweight or obesity, diabetes, and cardiovascular disease were prevalent among cases of HS. Evidence suggests that extreme hyperthermia (pooled mean = 42.0°C [95% confidence interval (CI): 41.9, 42.1], range 40–44.8°C) with hot and dry skin (>99% of cases) and severe loss of consciousness (mean Glasgow Coma Scale <8 in 53.8% of cases) were the dominant clinical characteristics of classic HS. Hypotension, tachypnea, vomiting, diarrhea, and biochemical biomarkers indicating mild‐to‐moderate rhabdomyolysis, acute kidney, liver, heart injury, and coagulopathy were frequent at the onset. Concomitantly, stress hormones (cortisol and catecholamines) and biomarkers of systemic inflammation and coagulation activation were increased. HS was fatal in 1 in 18 cases (pooled case fatality rate = 5.6% [95%CI: 4.6, 6.5]).ConclusionsThe findings of this review suggest that HS induces an early multiorgan injury that can progress rapidly to organ failure, culminating in death, if it is not recognized and treated promptly.
Expression of neurotransmitters, vasculogenesis markers and myosin heavy chain isoforms in the masseter muscle of senescence‐accelerated mouse prone 8 mice
Authors: Nakamura Chiaki , Sato Iwao , Ueda Yoko , Kawata Shinichi , Nagahori Kenta , Omotehara Takuya , Yakura Tomiko , Natsuyama Yutaro , Li Zhong‐Lian , Itoh Masahiro 
Published: March 2023

AbstractBackgroundLearning and memory deficits and pathologic changes in the hippocampus caused by toothlessness and soft diet feeding are related to reduced masseter muscle (MM) function.ObjectiveMyosin heavy chain (MyHC) isoform expression in the MM also changes under different chewing conditions. The neurotransmitter calcitonin gene‐related peptide (CGRP) and vascular endothelial growth factor A (VEGF‐A) are involved in MM formation. However, the relationship between CGRP, VEGF‐A and MyHC isoforms in the MM in the senescence‐accelerated mouse prone 8 (SAMP8) strain, a model of learning and memory deficits, remains unclear.MethodsChanges in CGRP, VEGF‐A, vasculogenesis marker and MyHC isoform mRNA expression in the MMs of ageing SAMP8 and senescence‐accelerated mouse resistant 1 (SAMR1) mice was investigated through quantitative real‐time polymerase chain reaction (qRT–PCR) and in situ hybridization.ResultsqRT–PCR revealed obviously high CGRP levels in the SAMP8 mouse MM (p < .001). MyHC‐IId/x mRNA expression in the MM was higher in 24‐week‐old SAMP8 mice than 24‐week‐old SAMR1 mice (p < .001) but lower in slow‐MyHC SAMP8 mice than SAMR1 mice (p < .001). CGRP mRNA was observed on the muscle fibres of the SAMP8 mouse MM but not the SAMR1 mouse MM through in situ hybridization. Principal component analysis (PCA) revealed strong positive contributions of SAMP8‐MyHC‐IId/x, SAMP8‐CGRP, SAMR1‐MyHC‐emb, SAMR1‐CGRP, SAMR1‐VEGF‐A, SAMR1‐CD31, SAMP8‐VEGF‐A, and SAMP8‐CD31 in the MM at 12 and 24 weeks.ConclusionCalcitonin gene‐related peptide is also key for the MyHC‐IId/x and slow‐MyHC patterns in the MMs of SAMP8 mice.
Rehabilitation of pediatric retinoblastoma patients with ocular prostheses and their subsequent modifications: A 15‐year retrospective study
Authors: Legg Lydia R. , Ahmed Zain Uddin , Solano Armand K. , Seier Kenneth , O'Hara Bridget F. , Kapetanakos Melani , Huryn Joseph M. , Randazzo Joseph D. 
Published: March 2023

AbstractPurposeEnucleation is a common treatment modality performed for pediatric retinoblastoma patients, and the resultant defects are reconstructed using an ocular prosthesis. The prostheses are modified or replaced periodically, as the child develops due to orbital growth and patient‐error. The purpose of this report is to evaluate the replacement frequency of prostheses in the pediatric oncologic population.MethodsA retrospective review was completed by the two senior research investigators, of patients that had ocular prostheses fabricated following enucleation of their retinoblastoma from 2005 to 2019 (n = 90). Data collected from the medical records of the patient included the pathology, date of surgery, date of prosthesis delivery, and the replacement schedule of the ocular prosthesis.ResultsDuring the 15‐year study period, 78 enucleated observations (ocular prosthesis fabricated) were included for analysis. The median age of the patients at the time of delivery of their first ocular prosthesis was calculated to be 2.6 years (range 0.3–18 years). The median time to the first modification of the prosthesis was calculated to be 6 months. The time to modification of the ocular prosthesis was further stratified by age.ConclusionPediatric patients require modification of their ocular prostheses throughout their growth and development period. Ocular prostheses are reliable prostheses with predictable outcomes. This data is helpful to set an expectation among the patient, parent, and provider.
Clinicopathologic and gastrointestinal effects of administration of prednisone, prednisone with omeprazole, or prednisone with probiotics to dogs: A double‐blind randomized trial
Authors: Rak Mariola B. , Moyers Tamberlyn D. , Price Joshua M. , Whittemore Jacqueline C. 
Published: March 2023

AbstractBackgroundThe efffect of administering of probiotics or twice‐daily omeprazole on glucocorticoid‐induced gastric bleeding in dogs is unknown.HypothesisCompare gastrointestinal bleeding among dogs administered placebo, prednisone (2 mg/kg q24h), prednisone with omeprazole (1 mg/kg q12h), or prednisone with probiotics (Visbiome, 11.2‐22.5 billion CFU/kg q24h) for 28 days.AnimalsTwenty‐four healthy research dogs.MethodsDouble‐blinded, placebo‐controlled randomized trial. Clinical signs and endoscopic gastrointestinal mucosal lesion scores at baseline (t1), day 14 (t2), and day 28 (t3) were compared using split‐plot repeated‐measures mixed‐model ANOVAs.ResultsFecal score differed by treatment‐by‐time (F[6,40] = 2.65,P < .03), with higher scores in groups receiving prednisone att3thant1. Nineteen of thirty‐three episodes of diarrhea occurred in the prednisone with omeprazole group. Gastric mucosal lesion scores differed by treatment‐by‐time (F[6,60] = 2.86,P = .05), among treatment groups (F[3,60] = 4.9,P = .004), and over time (F[2,60] = 16.5,P < .001). Post hoc analysis revealed lesion scores increased over time for all groups receiving prednisone. Att3, scores for the prednisone (8.7 ± 4.9) and prednisone with probiotics (8.7 ± 4.9) groups differed significantly from placebo (1.8 ± 1.8;P ≤ .04), whereas scores for the prednisone with omeprazole (6.5 ± 5.5) group did not differ from placebo (P = .7). Ulcers occurred only in dogs receiving prednisone.Conclusions and Clinical ImportancePrednisone‐induced gastric bleeding. Co‐administration of omeprazole partially mitigated bleeding, but a similar protective benefit was not demonstrated by co‐administration of the evaluated probiotic.
Circulating neutrophil extracellular traps in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism
Authors: Li Ronald H. L. , Fabella Arianne , Nguyen Nghi , Kaplan Joanna L. , Ontiveros Eric , Stern Joshua A. 
Published: March 2023

AbstractBackgroundCats with hypertrophic cardiomyopathy (HCM) are at risk of cardiogenic arterial thromboembolism (CATE). Neutrophil extracellular traps (NETs) may be a potential biomarker and therapeutic target for cardiomyopathy in cats.Hypothesis/ObjectivesCharacterize NETs in cats with HCM or CATE. We hypothesized that circulating NETs assessed in the form of cell‐free DNA (cfDNA) and citrullinated histone H3 (citH3) are increased in cats with HCM and CATE and associated with reported predisposing factors for thrombus formation.AnimalsEighty‐five cats including client‐owned cats with HCM and CATE and staff‐ and student‐owned clinically healthy cats without HCM.MethodsAfter echocardiographic evaluations, NETs were measured as cfDNA and citH3.ResultsCats with CATE had significant increases in cfDNA (11.2 ng/μL; interquartile range [IQR], 8.1 to 29.6) compared to those without HCM (8.2 ng/μL; IQR, 5.7 to 11.7 μL;P = .01) and were responsible for 75% to 83% of cases with cfDNA fragments sized 100 to 2000 base pairs. Citrullinated histone 3, detected in 52% of cats with HCM (31.1 ng/mL; IQR, 16.9 to 29.8), was significantly lower than in those with CATE (48.2 ng/mL; IQR, 34.2 to 60.2;P = .007). The citH3 concentrations correlated significantly with reported risk factors of CATE, such as left atrial auricular velocity.Conclusions and Clinical ImportanceNeutrophil extracellualr traps, especially citH3, are increased in cats with HCM and CATE. They may serve as a novel therapeutic target and biomarker of thrombosis in cats with HCM.
Fluid balance in pediatric postoperative liver transplant recipients
Authors: Winters Jessica M. , Brocks Rebecca , Chapin Catherine A. , Lemoine Caroline P. , Superina Riccardo , Brandt Katherine A. , Sanchez‐Pinto L. Nelson , Barhight Matthew F. 
Published: March 2023

AbstractBackgroundPositive fluid balance (FB) is associated with poor outcomes in critically ill children but has not been studied in pediatric liver transplant (LT) recipients. Our goal is to investigate the relationship between postoperative FB and outcomes in pediatric LT recipients.MethodsWe performed a retrospective cohort study of first‐time pediatric LT recipients at a quaternary care children's hospital. Patients were stratified into three groups based on their FB in the first 72 h postoperatively: <10%, 10–20%, and > 20%. Outcomes were pediatric intensive care unit (PICU) and hospital length of stay, ventilator‐free days (VFD) at 28 days, day 3 severe acute kidney injury, and postoperative complications. Multivariate analyses were adjusted for age, preoperative admission status, and Pediatric Risk of Mortality (PRISM)‐III score.ResultsWe included 129 patients with median PRISM‐III score of 9 (interquartile range, IQR 7–15) and calculated Pediatric End‐stage Liver Disease score of 15 (IQR 2–23). A total of 37 patients (28.7%) had 10–20% FB, and 26 (20.2%) had >20% FB. Greater than 20% FB was associated with an increased likelihood of an additional PICU day (adjusted incident rate ratio [aIRR] 1.62, 95% CI: 1.18–2.24), an additional hospital day (aIRR 1.39, 95% CI: 1.10–1.77), and lower likelihood of a VFD at 28 days (aIRR 0.85, 95% CI: 0.74–0.97). There were no differences between groups in the likelihood of postoperative complications.ConclusionsIn pediatric LT recipients, >20% FB at 72 h postoperatively is associated with increased morbidities, independent of age and severity of illness. Additional studies are needed to explore the impact of fluid management strategies on outcomes.
Combining the advocacy coalition framework and argumentative discourse analysis: The case of the “energy efficiency first” principle in EU energy and climate policy
Authors: von Malmborg Fredrik 
Published: March 2023

AbstractThis article combines, in a complementary way, the Advocacy Coalition Framework (ACF) with argumentative discourse analysis to analyze the politics of the “energy efficiency first” (EE1) principle as a new legal institute in European Union energy and climate policy. Two different discourses and storylines were identified. The first is where the meaning of energy efficiency policy is to fulfill multiple benefits. It is associated with a strong regulation of EE1. The second is where the purpose of energy efficiency policy is primarily to contribute to mitigating climate change. It is associated with weak regulation of EE1. Four advocacy coalitions with different secondary beliefs regarding the EE1 principle were identified. Analyzing the inter‐discursive communication between different coalitions provides insights to the policy‐oriented learning taking place. It is concluded that studies using the ACF could merit from focusing more on narratives and communication between belief systems.Related ArticlesKanol, Direnç. 2022. “Narrative Strategies for Emerging Disruptive Technologies: A Case Study of Blockchain for Europe.” Politics & Policy 50(5): 952–66. https://doi.org/10.1111/polp.12492.Nowlin, Matthew C., Maren Trochmann, and Thomas M. Rabovsky. 2022. “Advocacy Coalitions and Political Control.” Politics & Policy 50(2): 201–24. https://doi.org/10.1111/polp.12458.O'Donovan, Kristin T. 2018. “Does the Narrative Policy Framework Apply to Local Policy Issues?” Politics & Policy 46(4): 532–70. https://doi.org/10.1111/polp.12265.
The relationship between personality, social capital, and life satisfaction of elderly Koreans
Authors: Oh Eun‐A , Bae Sung‐Man 
Published: March 2023

BackgroundThere are very few studies that explain the life satisfaction of the elderly by considering both internal factors such as personality and social capital. Therefore, this study analyzed the relationship between personality, social capital, and life satisfaction among elderly Koreans.MethodsThis study analyzed the survey data on Koreans' happiness and quality of life 2019. Participants included a total of 1280 elderly adults aged 60–79 years.ResultsA multiple hierarchical regression analysis indicated that higher health status was related to higher life satisfaction, while neuroticism was negatively related to life satisfaction. Of particular note, increased structural and cognitive social capital were associated with higher life satisfaction. However, income, financial problems, and extraversion were not related to life satisfaction. The total explanatory amount of the regression model was 38.5%.ConclusionsThese findings suggest that researchers and clinicians should consider a combination of factors associated with both personality and social capital when aiming to improve life satisfaction for the elderly.
A global review of protected species interactions with marine aquaculture
Authors: Bath Gretchen E. , Price Carol A. , Riley Kenneth L. , Morris James A. 
Published: March 2023

AbstractAs marine aquaculture expands around the world, there is increased concern for impacts to protected species. Documented cases of marine mammal, sea turtle, seabird, and shark interactions with aquaculture installations do exist but are challenging to find. This extensive review summarises the state of knowledge of protected species interactions with marine fish and shellfish aquaculture installations. Although seaweed aquaculture was beyond the scope of this review, some of the findings for shellfish and finfish aquaculture may be relevant. The potential impacts of farms including habitat exclusion, entanglement, entrapment, collisions, and behavioural modifications are the primary risks posed to protected species by marine aquaculture facilities and operations. In addition, indirect effects from habitat impacts of farm operations may be of concern in some areas as well as the cumulative impacts of multiple small or large farms in the same general vicinity. Decades of farm innovations and best management practices have been driven by industry, natural resource managers, conservation organisations, and international conservation agreements. This review is useful for informing industry planning and permitting to develop aquaculture in the open ocean. This work will help advance the science of conservation by synthesising the state of knowledge and provide managers and industry with more insight to protect the most vulnerable species.
Oral health issues of late Baby Boomers (1956–1964)
Authors: Chávez Elisa M. 
Published: March 2023

AbstractObjectiveTo examine the issues and forces on the oral health of late Baby Boomers born in 1956–1964 that have shaped their oral health status and the opportunities and disparities in oral health care that this generational cohort has experienced.MethodsPast and current literature on the oral health status of this cohort was reviewed in light of concurrent social, political, and economic climates in order to better understand current and future needs in oral health care for this generation.ResultsThe majority of late Baby Boomers have not yet had their 65th birthday. They have benefitted from more opportunities for education, preventive health care, and technological advances in dentistry and medicine than any other prior generation, including their big brothers and sisters—the early Baby Boomers. Yet they have had fewer economic advantages than the early Boomers. Age prevalent diseases, conditions, and medications common to older adults will pose new risks to oral health. Discrete, longitudinal data on oral health status and needs by generational cohort—such as for the late Baby Boomer cohort—is lacking.ConclusionsDespite retaining more of their dentition than any other generation, it also evident that over the course of their lifetime, poverty, racism, and limited education have been unrelenting barriers to oral healthcare and undermine outcomes of care.