bluuebunny/crossref_metadata_2025_split huggingface dataset:
Checklist identification of candidates for systemic therapy in adult patients with atopic dermatitis in Germany: A multicentre study
Authors: Heratizadeh A. , Mempel M. , von Kiedrowski R. , Hagl S. , Mosch T. , Fritz B. , Werfel T. 
Published: August 2023

AbstractBackgroundThe German S2k guideline is the first to include a checklist that captures atopic dermatitis (AD) signs and symptoms as well as the lack of treatment response to identify patients eligible for systemic therapy.ObjectivesIdentifying candidates for a start/switch of systemic therapy in adult AD patients in Germany by applying the S2k guideline's checklist.MethodsIn this German multicentre, cross‐sectional, non‐interventional study (German Clinical Trials Register number: DRKS00023296), adult patients with mild to severe AD were enrolled at dermatological outpatient clinics and offices between April and October 2021. Demographics, clinical characteristics and quality of life were collected using questionnaires during one single visit. Eligibility for a start/switch of systemic AD therapy was evaluated according to the criteria of the German S2k guideline's checklist.ResultsAtopic dermatitis patients (575) were included in the analysis. One hundred and sixty‐four patients (28.5%) received systemic (SYS) AD therapy and 411 patients (71.5%) did not (TOP). Of the TOP therapy patients, 38.7% were eligible to start systemic AD therapy, and about half of those (49.1%), were scheduled to start systemic AD therapy. The most frequent reason deciding against a systemic therapy was the patient's wish. Although 29.3% of SYS patients were eligible for a switch according to the criteria of the German S2k guideline's checklist, the majority (81.3%) did not switch AD therapy.ConclusionsThis is the first study on the implementation of the German S2k guideline's checklist in everyday care of AD patients in Germany. More than one‐third of the TOP patients were identified as eligible for systemic treatment. By applying the guideline's checklist criteria, another one‐third of SYS patients may have benefited from a change of current systemic therapy. The use of the German S2k guideline's checklist in routine care represents an important tool to ensure effective patient care and identify inadequately treated patients.
Risk of serious infection and infection mortality in patients with psoriasis: A nationwide cohort study using the Taiwan National Health Insurance claims database
Authors: Chen Teng‐Chou , Wang Ting‐Chun , Yiu Zenas Z. N. , Lee Meng‐Sui , Chen Li‐Chia , Chan K. Arnold , Griffiths Christopher E. M. , Ashcroft Darren M. ,   the Global Psoriasis Atlas (GPA)
Published: August 2023

AbstractBackgroundThe risks of serious infections that lead to hospitalization and mortality in patients with psoriasis in Asia have not been comprehensively studied.ObjectivesWe examined the incidence of serious infection and infection mortality in patients with psoriasis.MethodsThis population‐based retrospective cohort study used the Taiwan National Health Insurance claims database from 2000 to 2017. Adult patients with psoriasis were identified by a relevant International Classification of Diseases (ICD) code and matched to six comparators without psoriasis on age and sex. Psoriasis patients were categorized as having moderate‐to‐severe disease once exposed to systemic therapies, phototherapy or biologic therapies. The incidence of serious infection and infection mortality were identified by ICD codes from inpatient hospitalization and death registration. Cox proportional hazard models were used to compare the risk, and the results were adjusted for covariates and presented as adjusted hazard ratios (aHR) and 95% confidence interval (95% CI).ResultsOverall, 185,434 psoriasis patients and 1,112,581 comparators were included. A higher rate of serious infection (aHR: 1.21, 95% CI: 1.19–1.22) was found in patients with psoriasis compared to matched comparators without psoriasis, and the risk was enhanced when patients had moderate‐to‐severe psoriasis (aHR: 1.30, 95% CI: 1.27–1.34). Specifically, there was an increased risk of serious infection due to respiratory infections (aHR: 1.11, 95% CI: 1.09–1.13), skin/soft‐tissue infections (aHR: 1.57, 95% CI: 1.52–1.62), sepsis (aHR: 1.23, 95% CI: 1.19–1.27), urinary tract infections (aHR: 1.11, 95% CI: 1.08–1.14), hepatitis B (aHR: 1.18, 95% CI: 1.06–1.30) and hepatitis C (aHR: 1.49, 95% CI: 1.32–1.69). Furthermore, psoriasis patients were associated with a higher risk of infection‐related mortality (aHR: 1.15, 95% CI: 1.11–1.18) compared to matched comparators.ConclusionPatients with psoriasis had a higher risk of serious infection and infection mortality, which was enhanced by moderate‐to‐severe psoriasis. Practitioners should be aware of the increased risk in patients with psoriasis, but it should not be a barrier to offering effective treatment.
Regulation of epithelial cell differentiation by the Ubiquitous expressed transcript isoform 1 in ulcerative colitis
Authors: Peng Wu , Zeng Chengcheng , Xu Jing , Zhao Hailan , Zhu Qingqing , Xu Haoming , Chen Huiting , Huang Hongli , Zhou Yongjian , Zhao Chong 
Published: August 2023

AbstractBackground and AimMucosal healing has emerged as a desirable treatment goal for patients with ulcerative colitis (UC). Healing of mucosal wounds involves epithelial cell proliferation and differentiation, and Y‐box transcription factor ZONAB has recently been identified as the key modulator of intestinal epithelial restitution.MethodsWe studied the characteristics of UXT‐V1 expression in UC patients using immunohistochemistry and qPCR. The functional role of UXT‐V1 in the colonic epithelium was investigated using lentivirus‐mediated shRNA in vitro and ex vivo. Through endogenous Co‐immunoprecipitation and LC–MS/MS, we identified ZONAB as a UXT‐V1‐interactive protein.ResultsHerein, we report that UXT‐V1 promotes differentiation of intestinal epithelial cells by regulating the nuclear translocation of ZONAB. UXT‐V1 was upregulated in the intestinal epithelia of UC patients compared with that of healthy controls. Knocking down UXT‐V1 in NCM‐460 cells led to the enrichment of pathways associated with proliferation and differentiation. Furthermore, the absence of UXT‐V1 in cultured intestinal epithelial cells and colonic organoids inhibited differentiation to the goblet cell phenotype. Mechanistically, the loss of UXT‐V1 in the intestinal epithelial cells allowed nuclear translocation of ZONAB, wherein it regulated the transcription of differentiation‐related genes, including AML1 and KLF4.ConclusionTaken together, our study reveals a potential role of UXT‐V1 in regulating epithelial cell differentiation, proving a molecular basis for mucosal healing in UC.
Catheter ablation and lower risk of incident dementia and mortality in older adults with atrial fibrillation
Authors: Harrison Stephanie L. , Buckley Benjamin J. R. , Austin Philip , Lane Deirdre A. , Lip Gregory Y. H. 
Published: August 2023

AbstractBackgroundAtrial fibrillation (AF) has consistently been associated with a higher risk of incident dementia. Observational evidence has suggested catheter ablation may be associated with a lower risk of dementia in patients with AF, but further research is needed. The objectives of this study were to use a global health research network to examine associations between catheter ablation, incident dementia and mortality in older adults with AF, and amongst subgroups by age, sex, co‐morbidity status, and oral anticoagulant use.MethodsThe research network primarily included healthcare organizations in the United States. This network was searched on 28th September 2022 for patients aged ≥65 years with a diagnosis of AF received at least 5 years prior to the search date. Cox proportional hazard models were run on propensity‐score matched cohorts.ResultsAfter propensity score matching, 20,746 participants (mean age 68 years; 59% male) were included in each cohort with and without catheter ablation. The cohorts were well balanced for age, sex, ethnicity, co‐morbidities, and cardiovascular medications received. The risk of dementia was significantly lower in the catheter ablation cohort (Hazard Ratio 0.52, 95% confidence interval: 0.45–0.61). The catheter ablation cohort also had a lower risk of all‐cause mortality (Hazard Ratio 0.58, 95% confidence interval: 0.55–0.61). These associations remained in subgroup analyses in individuals aged 65–79 years, ≥80 years, males, females, participants who received OACs during follow‐up, participants with paroxysmal and non‐paroxysmal AF, and participants with and without hypertension, diabetes mellitus, ischemic stroke, chronic kidney disease and heart failure, including heart failure with preserved ejection fraction and heart failure with reduced ejection fraction.ConclusionThe observed lower risk of dementia and mortality with catheter ablation could be an important consideration when determining appropriate patient‐centered rhythm control strategies for patients with AF. Further studies including data on the success of ablation are required.
A Delphi study to obtain consensus on medical emergency team (MET) stand‐down decision making
Authors: Kondos Natalie A. , Barrett Jonathan , McDonall Jo , Bucknall Tracey 
Published: August 2023

AbstractAimA medical emergency team (MET) stand‐down decision is the decision to end a MET response and hand responsibility for the patient back to ward staff for ongoing management. Little research has explored this decision. This study aimed to obtain expert consensus on the essential elements required to make optimal MET call stand‐down decisions and the communication required before MET departure.DesignA Delphi design was utilised.MethodsAn expert panel of 10 members were recruited based on their expert knowledge and recent clinical MET responder experience in acute hospital settings. Participants were emailed a consent form and an electronic interactive PDF for each survey. Two rounds were conducted with no attrition between rounds. The CREDES guidance on conducting and reporting Delphi studies was used to report this study.ResultsConsensus by an expert panel of 10 MET responders generated essential elements of MET stand‐down decisions. Essential elements comprised of two steps: (1) the stand‐down decision that was influenced by both the patient situation and the ward/organisational context; and (2) the communication required before actioning stand‐down. Communication after the decision required both verbal discussions and written documentation to hand over patient responsibility. Specific patient information, a management plan and an escalation plan were considered essential.ConclusionThe Delphi surveys reached consensus on the actions and communication required to stand down a MET call. Passing responsibility back to ward staff after a MET call requires both patient and ward safety assessments, and a clearly articulated patient plan for ward staff. Observation of MET call stand‐down decision‐making is required to validate the essential elements.Implication for the Profession and Patient/or Patient CareIn specifying the essential elements, this study offers clinical and MET staff a process to support the handing over of clinical responsibility from the MET to the ward staff, and clarification of management plans in order to reduce repeat MET calls and improve patient outcomes.ImpactMinimal research has been focussed on the decision to hand responsibility back to ward staff so the MET may leave the ward with safety plan in place. This study provided expert consensus to optimise MET stand‐down decision‐making and the ultimate decision to end a MET call. Communication of agreed patient treatment and escalation plans is recommended before leaving the ward. This study can be used as a checklist for MET responder staff making these decisions and ward staff responsible for post‐MET call care. The aim being to reduce the likelihood of potentially preventable repeat deterioration in the MET patient population.Reporting MethodThe CREDES guidance on conducting and reporting Delphi studies.Patient or Public ContributionNone.
Trust in Difficult People: A Social Network Perspective
Authors: Opper Sonja , Zou Na 
Published: August 2023

AbstractWe all know people we find difficult to deal with. Some we trust despite major past transgressions, others we do not. What explains the difference? Rather than looking for explanations inside the trustor–trustee dyad, we focus on the embedding social structure. Our argument focuses on two features: network closure around the trustor and the embeddedness of the difficult contact. We test and confirm our argument using data from 384 Chinese managers. Our results show that managers who cite colleagues as difficult following a major transgression report higher trust the more the difficult contact is embedded within the manager's network. The effect is smaller (larger) if the manager is surrounded by a rather closed (open) social network. At a practical level, our study helps distinguish between social situations that facilitate trust and those that impede trust once interpersonal conflicts have tainted a relationship.
Your innovation or mine? The effects of partner diversity on product and process innovation
Authors: Belitski Maksim , Delgado‐Márquez Blanca L. , Pedauga Luis Enrique 
Published: August 2023

AbstractDespite a fundamental revolution in digital technology, along with an ancillary reduction in the cost of transmitting knowledge, the innovation literature on knowledge collaboration continues to hold on to the spatial localization of knowledge collaboration as a truism. Drawing on the open innovation literature and knowledge‐based view of firm innovation, this study explores key boundary conditions affecting the relationship between research and development (R&D) collaboration breadth, and product and process innovation. Using a large‐scale survey consisting of 25,813 observations of 14,784 firms in the United Kingdom during 2004–2020, we demonstrate that the breadth of knowledge collaboration with regional, national, and international partners directly affects product and process innovation. However, this relationship depends on the geographical location of the collaboration partner, the type of partner, and the firm's absorptive capacity. We found diminishing marginal returns to knowledge collaboration breadth for regional partners in product innovation, and an inverted U‐shaped relationship in R&D collaboration breadth with regional partners for process innovation and for national and international partners for product and process innovation. While investment in digital technologies only shifts the curve upwards, it is unlikely to change the direction of the relationship between R&D collaboration and a type of innovation outcome. On the contrary, an increase in the share of science, technology, engineering, and math graduates enables firms to leverage the negative effect of R&D collaboration breadth nationally and specifically for process innovation. Investment in digital technology and human capital increases absorptive capacity and reduces the transaction costs associated with over‐search and limited managerial capabilities and resources.
Effects of carotenoid supplementation on colour, growth and physiological function of the endemic dwarf chameleon fish (Badis badis)
Authors: Biswas Pradyut , Singh Soibam Khogen , Debbarma Reshmi , Dey Abhipsha , Waikhom Gusheinzed , Deb Suparna , Patel Arun Bhai 
Published: August 2023

AbstractThe global ornamental fish trade is expanding in response to increased demand for indigenous fish on the global market, while exogenous carotenoids can improve colouration. The 60‐day trial investigated the effect of carotenoid supplementation, via Artemia, on colouration, growth and immunophysiology of Badis badis (dwarf chameleon fish). Carotenoid was enriched at 40 ppm (T1), 80 ppm (T2) and 120 ppm (T3) and compared with controls, C1 (unenriched) and C2 (oil‐enriched). Fish larvae (average weight 0.12 g) were fed enriched–unenriched Artemia in triplicates (5 × 3) in aquarium tanks (15 L). C1 and T2 had better skin colour (lightness and whiteness) in the posterolateral and caudal fins respectively. The value of redness (a*) in the anterolateral region was higher in T2 and T3 (p < 0.05). The anterolateral red index was higher (p < 0.05) in T2 and T3, whereas in the posterolateral and caudal fins, T1 and T2 were higher (p < 0.05). Compared to C1 and C2, the hue angle in carotenoid groups was found to be low (p < 0.05). No significant change in the growth performance was noticed (p > 0.05). Immune scores such as lysozyme and alkaline protease were highest in T3 (p < 0.05), whereas protease activity was highest in T2 (80 ppm). Stress biomarkers, viz., superoxide dismutase, catalase and malondialdehyde were low in groups fed enriched Artemia (p < 0.05). The integrated biomarker response means and star plot area were lower in the enriched groups (T1–T3), while T2 was the lowest. Overall findings reveal that dietary carotenoid improves the colouration and immune status, but fail to promote growth. Furthermore, 80 ppm enrichment dose improves the overall performance. The findings can help fish keepers improve fish colour and health status through carotenoid supplementation.
From individual to general experience
Authors: Berninger Anja 
Published: August 2023

AbstractThere has been some debate recently about whether we can come to know what an experience is like that we have not been through ourselves. Mostly, this debate focuses on general phenomenal knowledge. It is asked, for instance, whether we can come to know what it is like to be a refugee generally speaking (as opposed to being some specific refugee). In this paper, I want to add to this debate by trying to come to know how and to what extent someone who has been through the experience in question acquires this sort of general knowledge. I suggest that this form of general phenomenal knowledge is only acquired if the experience one has undergone is typical for the group in question.
Economic transition, dualism and informality inIndia: Nature and patterns of household‐level transitions
Authors: Kesar Surbhi 
Published: August 2023

AbstractWe examine the Indian economy during a peak period of high growth between 2005 and 2012 to analyse the nature and patterns of household‐level transitions across different sectors, characterised by varying degrees of formality/informality and various production structures and labour processes. We find that even within this brief period, there has been a huge volume of household‐level transitions across sectors. However, the overall economic structure, and its segmentations, has continued to be reproduced, along with a regeneration of ‘traditional’ non‐capitalist informal spaces. To ascertain the nature of household‐level transitions in terms of economic well‐being, we employ a counterfactual analysis. We find that majority of transitions in the economy have been ‘unfavourable’ in nature, with large proportion of households undergoing sectoral transitions that are not optimal for them, given their socio‐economic characteristics. Furthermore, the likelihood of ‘favourable’ versus ‘unfavourable’ sectoral transition, on average, significantly varies with household characteristics, some of which, like social caste, are structurally given and cannot be optimally chosen by households. Drawing upon this analysis, we reflect on the competing strands of literature that seek to explain the persistence of informality. Our analysis highlights the complexity of India's contemporary development trajectory, whereby the pre‐existing economic structure is reproduced, paradoxically, through a continuous reshuffling and reconstitution of economic spaces, accompanied by significant volume of ‘unfavourable’ household‐level sectoral transitions.
Functional groups and mineralization kinetics of soil organic matter under contrasting hydro‐thermal regimes under conservation agriculture‐based rice–wheat system in eastern Indo‐Gangetic Plains
Authors: Dey A. , Dwivedi B. S. , Bhattacharyya R. , Datta S. P. , Meena M. C. , Jat R. K. , Jat M. L. , Sarkar D. J. , Kumar R. 
Published: August 2023

AbstractSoil organic carbon (SOC) sequestration is important to counteract anthropogenic climate change at the global level. Studying the effect of conservation agriculture (CA) on SOC dynamics in the presence of two distinctively different hydro‐thermal regimes across the year in rice–wheat (RW) systems in eastern Indo‐Gangetic Plains (E‐IGP) is of topical interest. The stabilization mechanism of soil organic matter (SOM), and its effect on C mineralization kinetics in these conditions is not well understood. We collected soil samples from six combinations of CA and conventional farming in an ongoing experiment at CIMMYT‐Borlaug Institute for South Asia, Bihar, India. CA enhanced SOC, specifically labile C, while decreasing mineral N, as a result of encapsulation/assimilation in aggregates/microbial biomass. Humic acids registered characteristic Fourier transform infrared (FTIR) peaks at 3200–3600 cm−1, 2920–2930 cm−1, 1645–1655 cm−1 and 1220–1240 cm−1, and displayed lesser degree of humification, aromaticity and redox status under CA. SOC and N mineralization were studied in two different hydro‐thermal regimes pertaining to rice (submergence, 35°C; SM35) and wheat (field capacity, 25°C; FC25) growing periods of E‐IGP. SM35 displayed temperature‐mediated higher decay of SOC. Decay constants of C mineralization were lesser under CA compared with CT. CA promoted higher SOM stability, evidenced by lower decay rates of SOC and N, attributed to (1) better protection of SOM in well‐aggregated soil structure and (2) an excess supply of fresh crop residues ensuring higher rate of SOM formation than its decay. Practising CA in E‐IGP is imperative towards C‐neutral agriculture, especially in the impending global warming scenario.
Measurement of uncertainty tolerance revisited
Authors: Poço Paula Cristina Eiras , Collares Carlos Fernando , Haydar Ahmed , de Oliveira Victor Braga , de Arruda Martins Milton , Tempski Patricia Zen 
Published: August 2023

AbstractIntroductionUncertainty tolerance (UT) is attracting increasing attention in medical education due to the numerous challenges associated with uncertainty in professional life. Inconsistencies in analysing the relationship between UT and moderators may arise from inadequate measurement methods. Most instruments were formulated before the most widely accepted framework was published. Our aim was to investigate the validity of an UT scale using an actual framework to corroborate with better and accurate instruments.MethodsA total of 1052 students were invited. Various psychometric methods were used to explore validity of the TAMSAD scale in light of actual framework. Classic exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed. Secondly, content item classification was triangulated with exploratory graph analysis (EGA), and the new EFA, CFA, and cognitive diagnostic modelling (CDM) analysis were conducted. The reliability was calculated using Cronbach's alpha and McDonald's omega.ResultsA total of 694 students (65.9%) responded to the questionnaire. The reliability of the TAMSAD scale was 0.782. The initial EFA revealed no clear interpretable dimensions. The TAMSAD scale items can be classified into sources of uncertainty. The EGA has three dimensions, and the new EFA led to a 17‐item TAMSAD scale with the following three dimensions: ambiguity, complexity, and probability. These dimensions lead to better adjustment fit indices in the new CFA and CDM analyses.ConclusionWe found evidence that the TAMSAD scale can be considered a multidimensional scale, organised in terms of sources of uncertainty.