bluuebunny/crossref_metadata_2025_split huggingface dataset:
ML-SocMedEmot: Machine Learning Event-based Social Media Emotion Detection Proactive Framework Addressing Mental Health: A Novel Twitter Dataset and Case Study of COVID-19
Authors: Ismail Leila , Shahin Nada , Materwala Huned , Hennebelle Alain , Frermann Lea 
Published: September 2023

Abstract
Global rapidly evolving events, e.g., COVID-19, are usually followed by countermeasures and policies. As a reaction, the public tends to express their emotions on social media platforms. Therefore, predicting emotional responses to events is critical to put a plan to avoid risky behaviors. This paper proposes a machine learning-based framework to detect public emotions based on social media posts in response to specific events. It presents a precise measurement of population-level emotions which can aid governance in monitoring public response and guide it to put in place strategies such as targeted monitoring of mental health, to react to a rise in negative emotions in response to lockdowns, or information campaigns, for instance in response to elevated rates of fear in response to vaccination programs. We evaluate our framework by extracting 15,455 tweets. We annotate and categorize the emotions into 11 categories based on Plutchik’s study of emotion and extract the features using a combination of Bag of Words and Term Frequency-Inverse Document Frequency. We filter 813 COVID-19 vaccine-related tweets and use them to demonstrate our framework’s effectiveness. Numerical evaluation of emotions prediction using Random Forest and Logistic Regression shows that our framework predicts emotions with an accuracy up to 95%.
The mechanical test as a supplemental decision support tool for the safe removal of an Ilizarov circular external fixator
Authors: Xu Yulin , Liu Jialin , Yang Jinghong , Zhang Tao , Li Zhong , Liu Yanshi 
Published: September 2023

Abstract

Background
Timing the fixator removal is vital for a successful external fixation treatment. The purpose of this study was to determine the effectiveness of axial load-share ratio in vivo as a supplemental decision support tool for the safe removal of an Ilizarov circular external fixator.
Methods
This prospective observational study consists of 83 patients undergoing tibial or femoral lengthening with Ilizarov circular external fixation in our institution, from January 2011 to October 2019. In group Ⅰ (38 patients), the external fixator was removed based on the surgeon’s clinical experience and radiographs from January 2011 to June 2015. In group Ⅱ (45 patients), from July 2015 to October 2019, the supplemental axial load-share (LS) ratio test was accomplished without the knowledge of the clinical results by another medical team. The test was performed by electronically measuring forces in the fixator rods and in a ground force plate. When the LS ratio < 10% was consistent with the conclusion (dense bone formation was achieved in the distraction zone) drawn from the corresponding routine radiographs by the treating surgeon, the external fixator was removed.
Results
There was no statistical significance in demographic data between the two groups (P > 0.05). In group Ⅰ, 4 of the 38 patients suffered refracture (the refracture rate was 10.5%) after fixator removal, and bone union was finally achieved with further intervention by intramedullary nail. In group Ⅱ, 36 patients terminated the external fixation after the first mechanical test, and another 9 patients terminated the external fixation at the subsequent test. None of the 45 patients in group Ⅱ suffered refracture (the refracture rate was 0%). There was statistical significance in the refracture rate between the two groups (P < 0.05).
Conclusions
Adequate assessment of bone regenerate is crucial before removing an external fixator to prevent deformation or refracture. The axial load-share ratio in vivo is a practically quantitative method to supplement radiography and clinical experience for the assessment of regenerate healing, and the axial load-share ratio dropped below 10% is a safe limit for the Ilizarov circular external fixator removal.
Time Series Prediction of Echo State Network Based on Chebyshev Mapping and Strongly Connected Topology
Authors: Xie Minzhi , Wang Qianxue , Yu Simin 
Published: September 2023

Abstract
This paper introduces a novel approach called Chebyshev mapping and Strongly Connected topology for optimization of Echo State Networks (ESNs). To enhance the predictive performance of ESNs for time series data, Chebyshev mapping is employed to optimize the irregular input weight matrix. And the reservoir of the ESN is also replaced using an adjacency matrix derived from a digital domain chaotic system, resulting in a reservoir with strong connectivity properties. Numerical experiments are conducted on various time series datasets, including the Mackey-Glass time series, Lorenz time series, and solar sunspot numbers, validating the effectiveness of the proposed optimization methods. Compared with the traditional ESNs, the optimization method proposed in this paper has higher predictive performance, and effectively reduce the reservoir's size and model complexity.
State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased
Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis
Authors: Francesconi Valeria , Rizzo Marco , Schenone Silvia , Carbone Anna , Tonelli Michele 
Published: September 2023

Abstract:
Protozoan parasites represent a significant risk for public health worldwide, afflicting
particularly people in more vulnerable categories and cause large morbidity and
heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, route
of administration, and cost, reflecting their low priority in global health management.
Moreover, the drug resistance phenomenon threatens the positive therapy outcome. This
scenario claims the need of addressing more adequate therapies. Among the diverse strategies
implemented, the medicinal chemistry efforts have also focused their attention on
the benzimidazole nucleus as a promising pharmacophore for the generation of new drug
candidates. Hence, the present review provides a global insight into recent progress in
benzimidazole-based derivatives drug discovery against important protozoan diseases,
such as malaria, leishmaniasis and trypanosomiasis. The more relevant chemical features
and structure-activity relationship studies of these molecules are discussed for the purpose
of paving the way towards the development of more viable drugs for the treatment of these
parasitic infections.
3D Printed Personalized Colon-targeted Tablets: A Novel Approach in Ulcerative Colitis Management
Authors: Mishra Yachana , Mishra Vijay , Aljabali Alaa A.A. , El-Tanani Mohamed , Naikoo Gowhar A. , Charbe Nitin , Chava Sai Raghuveer , Tambuwala Murtaza M. 
Published: September 2023

Abstract:Ulcerative colitis (UC) and Crohn's disease (CD) are two types of idiopathic inflammatory bowel disease (IBD) that are increasing in frequency and incidence worldwide, particularly in highly industrialized countries. Conventional tablets struggle to effectively deliver anti-inflammatory drugs since the inflammation is localized in different areas of the colon in each patient. The goal of 3D printing technology in pharmaceutics is to create personalized drug delivery systems (DDS) that are tailored to each individual's specific needs. This review provides an overview of existing 3D printing processes, with a focus on extrusion-based technologies, which have received the most attention.:Personalized pharmaceutical products offer numerous benefits to patients worldwide, and 3D printing technology is becoming more affordable every day. Custom manufacturing of 3D printed tablets provides innovative ideas for developing a tailored colon DDS. In the future, 3D printing could be used to manufacture personalized tablets for UC patients based on the location of inflammation in the colon, resulting in improved therapeutic outcomes and a better quality of life.
Pil-Pintar Intervention Reduce Anemia among Young Teen Girls: A Pilot
Study
Authors: Muwakhidah M. , Rahmawaty Setyaningrum , Rakhma Luluk Ria , Widiyaningsih Endang Nur , Hidayati Listyani , Rusdanurmaala Shofianabila 
Published: September 2023

Background:
Iron deficiency anemia and low adherence to take iron tablets are prevalent
issues among teenage school girls in Indonesia. To address this concern and encourage regular
iron supplementation, the public health office of Sukoharjo Central Java Indonesia introduced a
pil-pintar program, colloquially known as the “smart pill.”

Aims:
This study aimed to measure the increase in hemoglobin (Hb) levels and its correlation with
nutrient intake related to Hb synthesis following the pil-pintar intervention.

Methods:
A quasi-experimental design with a one-group pre-posttest approach was performed involving
49 school teenage girls aged 12-15 years in a public school in Sukoharjo, Indonesia. Each
student was given an iron sugar coat tablet containing 182 mg of ferrous-fumarate (equivalent to
60 mg elemental iron) and 0.400 mg of folic acid per tablet, called pil-pintar, once a week for 12
weeks.

Results:
A decrease in anemia prevalence by 24.4% and a notable increase in Hb levels by 1.0
mg/dL (p = 0.001) were observed in the 12 weeks of intervention. However, the study found no association
between the nutrient intakes related to Hb production and the resulting Hb levels.

Conclusion:
The pil-pintar program effectively improved the hemoglobin levels of anemic teenage
girls in the Sukoharjo district, Indonesia.
The Mechanism of Plantaginis Semen in the Treatment of Diabetic
Nephropathy based on Network Pharmacology and Molecular Docking
Technology
Authors: He Linlin , Shen Kai , He Lei , Chen Yuqing , Tang Zhiyuan 
Published: September 2023

Background:
Diabetic nephropathy (DN) is one of the common complications of diabetes. Plantaginis Semen (PS) has a variety of therapeutic effects, however its mechanism on DN is unclear.

Objective:
This paper aims to find the ingredients, the key targets, and the action pathways of PS on DN from the perspective of network pharmacology.

Methods:
The databases of network pharmacology, such as Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Pharmmapper, OMIM, DrugBank, Gene-Cards, TTD, Disgenet, STRING, and Cytoscape software, were used to find the main ingredients and targets. Gene Ontology (GO) function and Kyoto Encyclopedia of Genome and Genomes (KEGG) pathway enrichment analysis were used to reveal the potential pathways of the PS on DN. The GEO database was used to find the targets of DN based on valid experimental research. The molecular docking technology was used to evaluate the combination between ingredients of PS and the targets.

Results:
A total of 9 active ingredients and 216 potential therapeutic targets were obtained for PS on DN. Hub targets were discovered by the Cytoscape software analysis. CASP3 was screened by Venn diagram by making intersection between GSE30529 and hub genes. Moreover, CASP3 was combined with one of the nine active ingredients, quercetin, by molecular docking analysis. The KEGG pathways were mainly involved in diabetic nephropathy, and were simultaneously associated with CASP3 as followed: AGE-RAGE signaling pathway in diabetic complications, apoptosis, lipid and athero-sclerosis, MAPK signaling pathway, TNF signaling pathway, IL-17 signaling pathway, and p53 signaling pathway.

Conclusion:
PS can have the treatment on DN through CASP3. Quercetin, as one of the nine active ingredients, can be bounded to CASP3 to inhibit apoptosis in DN. PS can also take action on DN probably through many pathways. The role of PS on DN through other pathways still needs to be further elaborated.
Autoimmune Responses and Therapeutic Interventions for Systemic
Lupus Erythematosus: A Comprehensive Review
Authors: Pandey Surya Prakash , Bhaskar Rakesh , Han Sung Soo , Narayanan Kannan Badri 
Published: September 2023

Abstract:
Systemic Lupus Erythematosus (SLE) or Lupus is a multifactorial autoimmune disease of multiorgan malfunctioning of extremely heterogeneous and unclear etiology that affects multi-ple organs and physiological systems. Some racial groups and women of childbearing age are more susceptible to SLE pathogenesis. Impressive progress has been made towards a better under-standing of different immune components contributing to SLE pathogenesis. Recent investigations have uncovered the detailed mechanisms of inflammatory responses and organ damage. Various environmental factors, pathogens, and toxicants, including ultraviolet light, drugs, viral pathogens, gut microbiome metabolites, and sex hormones trigger the onset of SLE pathogenesis in genetical-ly susceptible individuals and result in the disruption of immune homeostasis of cytokines, macro-phages, T cells, and B cells. Diagnosis and clinical investigations of SLE remain challenging due to its clinical heterogeneity and hitherto only a few approved antimalarials, glucocorticoids, im-munosuppressants, and some nonsteroidal anti-inflammatory drugs (NSAIDs) are available for treatment. However, the adverse effects of renal and neuropsychiatric lupus and late diagnosis make therapy challenging. Additionally, SLE is also linked to an increased risk of cardiovascular diseases due to inflammatory responses and the risk of infection from immunosuppressive treat-ment. Due to the diversity of symptoms and treatment-resistant diseases, SLE management re-mains a challenging issue. Nevertheless, the use of next-generation therapeutics with stem cell and gene therapy may bring better outcomes to SLE treatment in the future. This review highlights the autoimmune responses as well as potential therapeutic interventions for SLE particularly focusing on the recent therapeutic advancements and challenges.
Dissipation of Water Energy by Using a Special Stilling Basin Via Three-dimensional Numerical Model
Authors: El-Saie Yasser , Saleh Osama , El-Sayed Marihan , Ali Abdelazim , Sadek Eslam El-Tohamy Yasser Mohamed 
Published: September 2023

Introduction:
The forced hydraulic jump characteristics were studied numerically using Flow-3D software. Rectangular and semi-cylindrical shape slices were used as obstacles with different arrangements in the stilling basin to dissipate the excess kinetic energy.

Methods:
Each shape type was tested under five values of discharges (60, 80, 100, 120, and 160 l s-1). The numerical results showed that the obstacles act as good energy dissipators, which decrease the hydraulic jump length and the length of the stilling basin as a result. The best case is installing three semi-cylindrical slices in the stilling basin, and energy dissipation ratios range from 48% to 63%, with an average difference of 14% from the values of classical hydraulic jumps, according to discharge values.

Results:
It should be noted that the semi-cylindrical slices have better performance on energy dissipation ratios than rectangular slices, which indicates concave surface models cause the flow to change its direction, and this leads to a stable hydraulic condition.

Conclusion:
Results of this work can be applied to a prototype by fixing three semi-cylindrical slices in the stilling basin at relative distances of 0.2, 0.5, and 0.8 from the end of the spillway, and this lead to maximize energy dissipation rates.
Nanoemulsion Based Supramolecular Drug Delivery Systems for
Therapeutic Management of Fungal Infections
Authors: Sethi Surjeet Kaur , Goel Honey , Chawla Viney 
Published: September 2023

Abstract:
Fungal infections are one of the significant causes of death worldwide. Antifungal agents are associated with several side effects and toxicities while treating these infections. To overcome these physicochemical and pharmacokinetic side effects of antifungal agents, supramolecular drug delivery systems can be employed. The emulsion-based supramolecular assemblies, i.e., micro-emulsion and nanoemulsion, can be functionalized to achieve targeted delivery of antifungal drugs at the desired body sites. Emulsion based supramolecular assemblies have the ability to minimize the side effects related to antifungal agents and enhance their efficacy and safety profile. The pre-sent review focuses on the severe fungal infections and antifungal agents available for their man-agement with their drawbacks. This review also introduces various emulsion-based supramolecular drug delivery approaches that may improve the usability of antifungal agents or reduce their side effects to treat fungal infections.
MicroRNAs Regulate Inhibitor of Apoptosis Proteins (IAPs) in Colorectal Cancer
Authors: Tanzadehpanah Hamid , Avan Amir , Ghayour-Mobarhan Majid , Ferns Gordon A. , Manoochehri Hamed , Sheykhhasan Mohsen , Mahaki Hanie 
Published: September 2023

Abstract:
Colorectal cancer (CRC) is the second most common cause of cancer mortality, with approximately 1.9 million new cases and 0.9 million deaths globally in 2020. One of the poten-tial ways to treat colorectal cancer may be through the use of molecular methods to induce cell apoptosis. Apoptosis is a natural cellular event that regulates the growth and proliferation of body cells and prevents cancer. In this pathway, several molecules are involved; one group promotes this process, and some molecules that are representative of inhibitors of apoptosis proteins (IAPs) inhibit apoptosis. The most important human IAPs include c-IAP1, c-IAP2, NAIP, Survivin, XIAP, Bruce, ILP-2, and Livin. Several studies have shown that the inhibition of IAPs may be useful in cancer treatment. MicroRNAs (miRNAs) may be effective in regulat-ing the expression of various proteins, including those of the IAPs family; they are a large sub-group of non-coding RNAs that are evolutionarily conserved. Therefore, in this review, the miRNAs that may be used to target IAPs in colorectal cancer were discussed.
Biochar, Clay, Zeolites, and Microorganism-based Methods for Remediation
of Heavy Metals
Authors: Monga Yukti , Sharma Shivangi , Singh Shivendra , Gupta Ashu 
Published: September 2023

Abstract:
The modern world of chemistry needs to find a sustainable solution for the remediation of
heavy metals. The method of solving heavy metal problems using abundant and easily available ways is
an integral part of green chemistry. This approach stimulates innovation among scientists. These procedures
increase performance and decrease the consumption of non-renewable resources, minimizing negative
impacts on the environment and less use of harmful chemicals. In this review, we have included some
natural ways for the remediation of heavy metals such as Biochar, Clay, Zeolites, and Microorganismbased
methods. We have also incorporated the mechanism of action of each of these procedures for the
betterment of the reader.
Internet-Based Inquiries From Users With the Intention to Overdose With Over-the-Counter Drugs: Qualitative Analysis of Yahoo! Chiebukuro
Authors: Kariya Azusa , Okada Hiroshi , Suzuki Shota , Dote Satoshi , Nishikawa Yoshitaka , Araki Kazuo , Takahashi Yoshimitsu , Nakayama Takeo 
Published: September 2023

Background
Public concern with regard to over-the-counter (OTC) drug abuse is growing rapidly across countries. OTC drug abuse has serious effects on the mind and body, such as poisoning symptoms, and often requires specialized treatments. In contrast, there is concern about people who potentially abuse OTC drugs whose symptoms are not serious enough to consult medical institutions or drug addiction rehabilitation centers yet are at high risk of becoming drug dependent in the future.

Objective
Consumer-generated media (CGM), which allows users to disseminate information, is being used by people who abuse (and those who are trying to abuse) OTC drugs to obtain information about OTC drug abuse. This study aims to analyze the content of CGM to explore the questions of people who potentially abuse OTC drugs.

Methods
The subject of this research was Yahoo! Chiebukuro, the largest question and answer website in Japan. A search was performed using the names of drugs commonly used in OTC drug abuse and the keywords overdose and OD, and the number of questions posted on the content of OTC drug abuse was counted. Furthermore, a thematic analysis was conducted by extracting text data on the most abused antitussive and expectorant drug, BRON.

Results
The number of questions about the content of overdose medications containing the keyword BRON has increased sharply as compared with other product names. Furthermore, 467 items of question data that met the eligibility criteria were obtained from 528 items of text data on BRON; 26 codes, 6 categories, and 3 themes were generated from the 578 questions contained in these items. Questions were asked about the effects they would gain from abusing OTC drugs and the information they needed to obtain the effects they sought, as well as about the effects of abuse on their bodies. Moreover, there were questions on how to stop abusing and what is needed when seeking help from a health care provider if they become dependent. It has become clear that people who abuse OTC drugs have difficulty in consulting face-to-face with others, and CGM is used as a means to obtain the necessary information anonymously.

Conclusions
On CGM, people who abused or tried to abuse OTC drugs were asking questions about their abuse expectations and anxieties. In addition, when they became dependent, they sought advice to quit their abuse. CGM was used to exchange information about OTC drug abuse, and many questions on anxieties and hesitations were posted. This study suggests that it is necessary to produce and disseminate information on OTC drug abuse, considering the situation of those who abuse or are willing to abuse OTC drugs. Support from pharmacies and drugstores would also be essential to reduce opportunities for OTC drug abuse.