bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of intermittent fasting on quality of life tolerance of chemotherapy in patients with gynecological cancers: study protocol of a randomized-controlled multi-center trial
Authors: Schmidt Mona Wanda , Brenner Walburgis , Gebhard Susanne , Schmidt Marcus , Singer Susanne , Weidenbach Lina , Hahn Harriett , Puzankova Diana , Blau-Schneider Bettina , Lehnert Antje , Battista Marco Johannes , Almstedt Katrin , Lütkemeyer Anja , Radsak Markus Philipp , Mähringer-Kunz Aline , Krajnak Slavomir , Linz Valerie Cathrine , Schwab Roxana , Gabriel Boris , Hasenburg Annette , Anic Katharina 
Published: July 2023

Fatigue is a very common side effect during intravenous chemotherapy. Unfortunately, only few effective therapeutic options are available, mostly based on daily activity. In our pilot trial we were able to demonstrate that intermittent fasting can reduce fatigue in healthy people, thus we aimed to assess the effects of the fasting dietary on quality of life during chemotherapy in patients with gynecological cancer, especially on the domain of fatigue. The IFAST trial is designed as a prospective, randomized-controlled, multi-center trial. Participation will be offered to women with gynecological cancers (breast cancer, ovarian cancer including peritoneal and fallopian tube cancers, endometrial cancer and cervical cancer) who are planned to receive intravenous chemotherapy for at least three months. Eligible patients will be randomized 1:1, stratified by tumor type and study center. Primary endpoint is the difference in mean change in fatigue, assessed with the Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT- FS©). Exploratory secondary endpoints will include general Quality of Life impairment, tolerance of chemotherapy, immunological changes, peripheral cell damage in blood cells, as well as tumor response to chemotherapy. There is new evidence that prolonged fasting periods of 46-96 hours during chemotherapy can positively influence the quality of life during chemotherapy. However, these fasting regiments are not feasible for many patients. Intermittent fasting could be a feasible (manageable) option for many patients to actively improve their quality of life and tolerance to chemotherapy and possibly even enhance the effectiveness of chemotherapy.Trial Registrationhttps://drks.de, identifier DRKS00031429.
The relationship between negative workplace gossip and thriving at work among Chinese kindergarten teachers: the roles of psychological contract breach and bianzhi
Authors: He Can , Feng Tongtong , Xiong Jie , Wei Hua 
Published: July 2023

IntroductionExploring the influencing factors and functioning mechanisms of thriving at work is of practical significance both for teachers and kindergartens. Based on the socially embedded model of thriving at work, this study aimed to examine the association between negative workplace gossip and thriving at work. The mediating role of psychological contract breach and the moderating role of bianzhi were also examined.MethodsA total of 1105 Chinese kindergarten teachers were chosen to complete a questionnaire on negative workplace gossip, psychological contract breach, and thriving at work.ResultsThe results demonstrated that negative workplace gossip was positively associated with psychological contract breach and negatively associated with thriving at work. In addition, psychological contract breach was negatively associated with thriving at work. According to the mediation model test, psychological contract breach was a mediating factor between negative workplace gossip and thriving at work. The impact of psychological contract breach on thriving at work could be further moderated by bianzhi.ConclusionThis study complements knowledge systems about the influential factors and functional mechanisms of thriving at work. In practical terms, this study offers a fresh and innovative perspective for kindergartens seeking to enhance teachers’ thriving at work.
Effectiveness of an app-based intervention to improve well-being through cultivating positive thinking and positive emotions in an adult sample: study protocol for a randomized controlled trial
Authors: Uribe Fabio Alexis Rincón , Favacho Maria Fernanda Monteiro , Moura Paula Marília Nascimento , Patiño Diana Milena Cortés , da Silva Pedroso Janari 
Published: July 2023

IntroductionInterventions to promote health and well-being based on the construction of psychological resources can positively impact the daily life of users and foster human flourishing. Nowadays, mobile health represents a safe way to support health research and implement evidence-based psychological interventions. The present study aims to evaluate the effectiveness of a mobile app-based intervention program (OneUS) designed to cultivate positive emotions and positive thinking to improve overall well-being.MethodsThe study is designed as a randomized controlled trial. Two hundred participants will be randomly assigned to either a mobile health intervention condition (OneUS App) or an active control condition. The intervention consists of a program to cultivate positive emotions and positive thoughts. The active control intervention will comprise a set of mental imagery exercises and daily routine recording. The primary outcome comprises optimal well-being assessed using the multidimensional PERMA-Profiler scale. The sample will include adult people from the general population, who will be assessed at 8 time points: baseline (t1), intervention (t2, t3, t4, t5, t6) post-intervention (t7) and 3-month follow-up (t8).DiscussionMobile apps seem to be promising tools to promote health and well-being. This study will evaluate the effectiveness of a mobile app (OneUS) aiming to cultivate positive emotions and positive thinking to improve well-being. The main strength of this study is the development of an evidence-based mobile health app, based on intentional mental training, to promote well-being. The limitations of this study relate to potential participant drop-out and the non-generalizability of the results to clinical populations.Clinical trial registrationhttps://ensaiosclinicos.gov.br/rg/RBR-43hpwqk, Identifier RBR-43hpwqk.
Cyber-infrastructure and epidemic precautionary policy: evidence from China
Authors: Gao Qiuming , Hu Youlong , Liao Zangyi , Yao Lu 
Published: July 2023

IntroductionThe application of technology supported by cyber infrastructure has emerged as a critical factor influencing city management. This study aims to investigate whether the development of cyber infrastructure can enhance cities’ confidence in responding to potential epidemic threats in the context of COVID-19.MethodsChina serves as a good example for both COVID-19 management and smart city construction. We take advantage of a special time point, the 2022 Chinese New Year, to observe cities’ precautionary epidemic policies. We utilize choice models and data from 188 Chinese cities to examine the impact of internet coverage on the degree of policy relaxation.ResultsWe found that cities with higher internet coverage tend to adopt looser policies. In the benchmark regression, for every 1 percentage point increase in internet coverage, the likelihood of implementing loose measures increases by 0.9 percentage points. This result remains robust across different classifications of policies. We also addressed potential endogeneity issues by using the instrumental variables method.DiscussionOur study indicates that effective management of epidemics in the modern era requires not only the utilization of traditional medical resources but also the incorporation of new city features, such as information technology infrastructure.
Viability and Desiccation Resistance of Bartonella henselae in Biological and Non-Biological Fluids: Evidence for Pathogen Environmental Stability
Authors: Bush Janice C. , Maggi Ricardo G. , Breitschwerdt Edward B. 
Published: July 2023

Pathogen environmental stability is an often-neglected research priority for pathogens that are known to be vector-transmitted. Bartonella henselae, the etiologic agent of Cat Scratch Disease, has become a “pathogen of interest” in several serious human illnesses, which include neoplastic, cardiovascular, neurocognitive, and rheumatologic conditions. Survival in the flea gut and feces as well as the association with a biofilm in culture-negative endocarditis provides insight into this organism’s ability to adjust to environmental extremes. The detection of B. henselae DNA in blood and tissues from marine mammals also raises questions about environmental stability and modes of pathogen transmission. We investigated the ability of B. henselae to survive in fluid matrices chosen to mimic potential environmental sources of infective materials. Feline whole blood, serum and urine, bovine milk, and physiologic saline inoculated with a laboratory strain of B. henselae San Antonio 2 were subsequently evaluated by culture and qPCR at specified time intervals. Bacterial viability was also assessed following desiccation and reconstitution of each inoculated fluid matrix. Bartonella henselae SA2 was cultured from feline urine up to 24 hours after inoculation, and from blood, serum, cow’s milk, and physiologic saline for up to 7 days after inoculation. Of potential medical importance, bacteria were cultured following air-desiccation of all fluid inoculates. The viability and stability of Bartonella within biological and non-biological fluids in the environment may represent a previously unrecognized source of infection for animals and human beings.
Preparation and Characterization of L-ascorbic Acid Ethosomal Formulation for Enhancement of Permeation
Authors: Alabada Ahmed , Mohammed Murtadaa 
Published: July 2023

Background: Vesicular system is a good approach to improve hydrophilic drug permeability using phospholipids as Nanocarriers to increase lipophilicity and reduce vesicle size. L-ascorbic acid is a water soluble vitamin with antioxidant activity with poor skin permeability. Aim: The purpose of this work is to prepare LAA-containing ethosomes formulations utilizing a modified thin film hydration approach. Methods: eight formulas were prepared using different types of phospholipids (egg yolk lecithin and soya lecithin), different volumes of ethanol (2 and 3mL), and tween 80 as a surfactant. The prepared formulas (F1, F2, F3, F4, F5, F6, F7 and F8) were characterized to detect the best one regarding the physical appearance, pH, average vesicle size, polydispersity index (PDI) and entrapment efficiency. Scanning electron microscope (SEM) and transmission electron microscope (TEM) were used to evaluate the morphological properties Results: The best prepared ethosomal formula was F3 which contains (1.5g) LAA, (0.1 g) egg yolk lecithin, (2 mL) ethanol, 0.025 mL tween 80 and (q.s.10mL) of distilled water. Its average vesicle size value (176nm), PDI = 0.243, high entrapment efficiency (89.8%) and good physical stability. The morphological properties showing spherical, smooth, and devoid of drug crystalline structures. The drug-excipient compatibility is confirmed using (FTIR, DSC and PXRD) analyses. Additionally, the Ex-vivo drug permeation investigation demonstrated that the prepared formula of LAA had flux and permeability coefficients that were two times higher than the control. Conclusions: The average vesicle size and PDI are affected by, the volume of ethanol, type of lecithin and presence of solubilizing agent.
Les marchands français de Cadix et la crise de la Carrera de Indias (1778-1828)
Authors: Bartolomei Arnaud 
Published: July 2023

Comment les acteurs économiques se déterminent-ils face aux choix cruciaux qu’ils sont amenés à faire au cours de leur existence ? Sont-ils guidés par le seul « goût du lucre » ? Ou par des calculs plus complexes, prenant en compte leur environnement social, familial et culturel ? Cette question ancienne, mais toujours d’actualité, aussi bien au sein des sciences sociales que dans le débat public, est abordée ici à partir de l’observatoire singulier des quelque 500 marchands français qui s’étaient installés à Cadix au xviiie siècle pour bénéficier des conditions commerciales exceptionnelles qu’offrait alors le grand port andalou de la Carrera de Indias - la mythique route du commerce colonial espagnol et des « fabuleux métaux ». À travers l’histoire de leurs trajectoires dans les temps troublés des guerres révolutionnaires, de l’épopée napoléonienne et de l’émancipation des colonies espagnoles, c’est à une plongée au cœur des logiques de décision des acteurs que nous invite l’auteur.
Some thoughts about eclogites and related rocks
Authors: Brown Michael 
Published: July 2023

Abstract. The past 40 years have been a golden age for eclogite studies, supported by an ever wider range of instrumentation and enhanced computational capabilities, linked with ongoing developments in thermobarometry and geochronology. During this time, we have made robust estimates of pressure–temperature (P–T) conditions; determined ages related to the prograde, metamorphic peak and retrograde stages; and calculated time-integrated rates of cooling and exhumation for eclogites and related rocks, including blueschists, from orogenic belts worldwide. Improvements to single mineral thermometers and new developments in elastic barometry using inclusions of one mineral in another (e.g. quartz and/or zircon in garnet), coupled with ongoing innovations in petrochronology and diffusion modelling, presage a new age for eclogite studies in which detailed quantification of metamorphic conditions and timescales will be linked to an improved understanding of processes at all scales. Since the turn of the century, numerical modelling of subduction zone and rock exhumation processes has become increasingly important. As a result, subduction and exhumation are quite well understood, but the volume of continental crust subducted to and returned from mantle conditions and the amount lost to the mantle are largely unknown. We have generated sufficient data to investigate the spatiotemporal distribution of metamorphism and secular change but not without controversy in relation to the rare occurrence of orogenic eclogites and the absence of blueschists prior to the late Neoproterozoic and the emergence of plate tectonics on Earth. Since the turn of the century, the assumption that metamorphic pressure is lithostatic has come under increasing scrutiny. Whether local variations in stress extrapolate to the crustal scale and, if so, whether the magnitude of the calculated deviations from lithostatic pressure can be generated and sustained in mechanically heterogeneous rock units remains contentious. Could the paradigm of subduction of continental lithosphere to mantle depths be simply an artefact of the lithostatic assumption? Fluid cycling in subduction zones and understanding the role of fluids in the generation of intermediate-depth earthquakes remain important topics of current research. Dry (H2O-absent) conditions are unlikely around the peak of ultrahigh-pressure (UHP) metamorphism or during exhumation, due to dehydroxylation of nominally anhydrous minerals and breakdown of hydrous minerals at P–T conditions in the realm of supercritical fluid and hydrous melt. Indeed, the presence of melt may be necessary to facilitate the exhumation of HP and UHP tectonometamorphic rock units. Finally, our ability to interrogate inclusions in superdeep diamonds should lead to a better understanding of how the deep interior and surface are linked in the context of Earth as a fully coupled system.
Integrated Effect of Heavy Metal-Tolerant Rhizobacteria and Phosphorus on Maize Growth and Phosphorus Bioavailability in Contaminated Soil
Authors: Nawaz Aman , Tariq Muhammad , Khan Kamal , Haq Mauz Ul , Khan Hassan 
Published: July 2023

Toxic metals significantly influence agricultural crop yields and adversely affect animals and humans. Hence, in the current study impact of different strains of phosphorus-solubilizing bacteria (PSB) and levels of phosphorus on the solubility of phosphorus and the stabilization of heavy metals in contaminated soil were studied in a greenhouse pot experiment in 2022. The PSB strains included Bacillus CUM6, Bacillus DUM7, and Bacillus PIS7. Phosphorus was applied at rates of 40, 60, and 80 kg P2O5 ha-1 using single superphosphate, with a basal dose of 120 kg N and 60 kg K2O ha-1. The experiment followed a randomized, two-factorial design. Maize plants (variety "Azam") were inoculated with the PSB strains. Consequently, combining Bacillus PIS7 with 80 kg P2O5 ha-1 significantly increased both fresh and dry maize biomass (35.33 and 24.56 g pot-1) compared to the control (unspiked soil). Phosphorus bioavailability (7.07 and 5.14 mg kg-1) significantly improved with 80 kg ha-1 phosphorus and Bacillus PIS7. Heavy metal concentrations in soil (Cd, Pb, Cr, and Ni) decreased significantly at 80 kg ha-1 phosphorus and Bacillus PIS7, and Cd concentrations in plants decreased to 3.31 mg kg-1 with Bacillus DUM7 and to 2.96, 0.42, and 1.33 mg kg-1 with Bacillus PIS7. The application of PSB strains and phosphorus fertilizer reduced heavy metal concentrations. Notably, 80 kg P2O5 ha-1 with Bacillus PIS7 showed the best performance. Phosphorus uptake increased significantly (0.106 mg pot-1), while heavy metal uptake (Cd, Pb, and Cr) decreased linearly with increasing phosphorus levels and PSB strains. Bacillus PIS7 with 80 kg P2O5 ha-1 had the lowest heavy metal translocation, doing better than the control and other PSB strains (Bacillus CUM6 and Bacillus DUM7). Soil characteristics indicated increased organic matter content (0.73%) and decreased pH (7.61) and electrical conductivity (0.17 dSm-1) with applied phosphorus and PSB strains, suggesting enhanced phosphorus bioavailability and reduced heavy metal concentrations. In conclusion, adding 80 kg P2O5 ha-1 with Bacillus PIS7 helps plants grow better when they are stressed by heavy metals and keeps Cd, Pb, Cr, and Ni stabilized in the soil.
Changes to fish assemblage following the selective removal of black bullhead (Ameiurus melas)
Authors: Jaćimović Milica Lj. , Smederevac‐Lalić Marija M. , Nikolić Dušan , Cvijanović Gorčin D. , Spasić Slađana Z. , Višnjić‐Jeftić Željka V. , Skorić Stefan B. , Krpo‐Ćetković Jasmina 
Published: July 2023

Abstract

Black bullhead is among the most abundant and successful non‐native fish species in European fresh waters. A number of studies have indicated that its physical removal might be a potential solution to minimize possible adverse impacts; however, so far there have been no field studies to confirm this.
This study quantified the population dynamics of both native and non‐native fishes in a small slow‐running lowland river within the Ponjavica Nature Park in Serbia before and after the black bullhead removal with fyke nets.
The removal of black bullhead resulted in statistically significant changes in the abundance of two native species – an increase in rudd (Scardinius erythrophthalmus) (by 5.3 times) and a decline in bleak (Alburnus alburnus) (by 2.3 times).
A significant increase was observed in three non‐native fish species – the abundances of topmouth gudgeon (Pseudorasbora parva), pumpkinseed (Lepomis gibbosus) and Prussian carp (Carassius gibelio) increased 25.5, 4.9 and 4.2 times, respectively.
There were also substantial changes in the diversity of the fish assemblage after the black bullhead removal, illustrated by changes in diversity indices: Shannon's index doubled, while the Simpson's dominance index decreased threefold.
The catch‐per‐unit‐effort and the biomass‐per‐unit‐effort values indicated the dominance of the black bullhead in the fish assemblage during the mass removal phase of the study. The young‐of‐the‐year/adult ratio did not vary in relation to abundance, which confirmed that black bullhead might not compensate for fishing mortality with increased recruitment.
The results suggest that black bullhead plays a significant role in structuring the fish assemblage and that its removal may have both positive and negative effects on species abundance and diversity. These findings can contribute to the conservation of native fish species and improvement of future management programmes.
Early Postoperative Serum Phosphate Drop Predicts Sufficient Hypertrophy after Liver Surgery
Authors: Kambakamba Patryk , Schneider Marcel A. , Linecker Michael , Kirimiker Elvan Onur , Moeckli Beat , Graf Rolf , Reiner Cäcilia S. , Nguyen-Kim Thi Dan Linh , Kologlu Meltem , Karayalcin Kaan , Clavien Pierre-Alain , Balci Deniz , Petrowsky Henrik 
Published: July 2023

Objective:
The aim of this study was to assess the impact of postoperative hypophosphatemia on liver regeneration after major liver surgery in the scenario of ALPPS (Associating Liver Partition with Portal vein ligation for Staged hepatectomy) and living liver donation (LLD).

Background:
Hypophosphatemia has been described to reflect the metabolic demands of regenerating hepatocytes. Both, ALPPS and LLD, are characterized by an exceptionally strong liver regeneration and may be of particular interest in the context of posthepatectomy hypophosphatemia.

Methods:
Serum phosphate changes within the first 7 postoperative days after ALPPS (n=61) and LLD (n=54) were prospectively assessed and correlated with standardized volumetry after one week. In a translational approach, postoperative phosphate changes were investigated in mice and in vitro.

Results:
After ALPPS stage-1 and LLD, serum phosphate levels significantly dropped from a preoperative median of 1.08 mmol/L (IQR 0.92-1.23) and 1.07 mmol/L (IQR 0.91-1.21) to a postoperative median nadir of 0.68 mmol/L and 0.52 mmol/L, respectively. A pronounced phosphate drop correlated well with increased liver hypertrophy (P<0.001). Patients with a low drop of phosphate showed a higher incidence of posthepatectomy liver failure after ALPPS (7 vs. 31%, P=0.041). Like in human, phosphate drop correlated significantly with degree of hypertrophy in murine ALPPS and hepatectomy models (P<0.001). Blocking phosphate transporter (Slc20a1) inhibited cellular phosphate uptake and hepatocyte proliferation in vitro.

Conclusion:
Phosphate drop after hepatectomy is a direct surrogate marker for liver hypertrophy. Perioperative implementation of serum phosphate analysis has the potential to detect patients with insufficient regenerative capacity at an early stage.