bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation and Evaluation of Quality Characteristics of Complementary
Food
Authors: Shravani Kopparam Amarnath , Thampy Anjana , Thabassum Anees Fathima , Shiva Kumara Chilkunda Sannaiah , Anandan Satish Kumara , Reddy Madhavi 
Published: February 2023

Background:
Banana (Genus Musa) cultivars have been farmed for a long time all
over the world. Various parts of this plant have nutritional and therapeutic applications. According
to research, various components of the banana can be used to cure ailments, such as diabetes,
hypertension, cancer, ulcers, diarrhea, urolithiasis, Alzheimer's, and infections. Despite such vast
knowledge about bananas, there is a lacuna in exploring the different varieties with their nutritional
value and suitability.

Objective:
The present study was carried out to analyze the nutritional composition of different
varieties of bananas and their consumption.

Methods:
Robusta, Rasakadali, and Red banana varieties were studied for their chemical and nutrient
composition and wide consumption.

Results:
Among the observed varieties, Robusta was found to have high protein (1.99 ± 0.10), fat
(0.18 ± 0.01), carbohydrates (78.76 ± 0.01), ash (1.23 ± 0.1), fiber (1.00 ± 0.10), and energy
(316.81 ± 0.00) as compared to other varieties. Minerals like calcium (6.25 ± 0.77), manganese
(0.81 ± 0.00), and iron (0.10 ± 0.00) were found to be slightly high in Robusta. Furthermore,
sensory acceptability results revealed that the cakes prepared by Robusta had the highest acceptability
scores.

Conclusion:
Robusta had better nutrient and chemical composition along with a good sensory
profile compared to the other two varieties and thus preferred for cake preparation.
Prescribing Pattern of Non-steroidal Anti-inflammatory Drugs (NSAIDs)
in the Middle East Region: A Critical Review
Authors: Al-Shargi Omar Yahya 
Published: February 2023

Background:
There exists a paucity of data on pharmacoepidemiologic and drug utilization
patterns of non-steroidal anti-inflammatory drugs (NSAIDs) in the Middle East region.

Objective:
The objective of this study was to provide a critical appraisal of the prescription patterns
of NSAIDs in the Middle East region.

Methods:
A literature search was conducted on the electronic databases such as MEDLINE,
Google Scholar, and ScienceDirect for studies conducted on prescription pattern of NSAIDs using
the keywords “Non-steroidal Anti-inflammatory Drugs”, “NSAIDs”, “Non-opioid Analgesics”,
“Antipyretics”, “Prescription Pattern”, “Drug Use indicators”, “Drug Utilization Pattern”,
“Pharmacoepidemiology”. The search was conducted within 5 months, from January to May
2021.

Results:
Studies from twelve Middle Eastern countries were analyzed and critically discussed. The
findings indicated widespread and clinically significant inappropriate prescribing in all Middle
East countries and territories. Furthermore, NSAIDs prescription pattern in the region extensively
varies with healthcare settings, patient’s age, patient’s medical presentation, history of comorbid
conditions, insurance type, and prescribers’ specialization and years of experience, among several
other factors.

Conclusion:
Low-quality prescribing based on indicators of the World Health Organization/
International Network of Rational Use of Drugs suggests the need to further improve the current
drug utilization trend in the region.
Evaluation of CNS Depressant and Anti-anxiety Activities of Leaves of
Convolvulus pluricaulis
Authors: Khan Sumayya , Kala Chandra , Goyal Manoj , Yadav Sandeep Kumar , Taleuzzaman Mohamad 
Published: February 2023

Background:
Convolvulus pluricaulis is a native plant that is commonly mentioned in Ayurveda as a Rasayana and is primarily recommended for use in mental stimulation and rejuvenation therapy. Convolvulus pluricaulis is used as a brain tonic. The plant is reported to be a prominent memory-improving drug. It is used as a psychostimulant and tranquilizer. It is reported to reduce men-tal tension.

Objective:
The present study aimed to explore the protective effect of hydroalcoholic extract from the leaves of Convolvulus pluricaulis, along with CNS depressant and anti-anxiety activities, in models of mice.

Methods:
The extract from leaves of Convolvulus pluricaulis were sequentially isolated with a mix-ture of water and alcohol solution in the soxhlet apparatus. An acute toxicity study was conducted as per OECD guidelines no. 423, in which 18 Albino male mice were treated with different doses (1, 10, 100, 500, 1000, and 2000 mg/kg) of hydroalcoholic extract of Convolvulus pluricaulis and assessed for toxicity parameters for 14 days. Various psychomotor activities of hydroalcoholic extract from leaves of Convolvulus pluricaulis for 100, 200, and 300 mg/kg doses were performed in mice by using various tests like actophotometer, open field, rota-rod, grip strength tests, elevated plus maze, hole board test, inclined plane, chimney test.

Results:
The hydroalcoholic extract from leaves of Convolvulus pluricaulis was found to fall under category 4 in the acute toxicity study. Therefore, 100, 200, and 300 mg/kg doses of hydroalcoholic ex-tract of leaves of Convolvulus pluricaulis were selected for the further pharmacological study. The re-sults of psychomotor tests (actophotometer, open field, rota-rod, grip strength, hole board test, inclined plane, chimney test, elevated plus maze, light-dark model) for test doses 100, 200, and 300 in mice showed CNS depressant and anti-anxiety effects.

Conclusion:
Hydroalcoholic extract from leaves of Convolvulus pluricaulis at the 100, 200, and 300 mg/kg doses has shown CNS depressant and anti-anxiety effects in mice models.
Hypoglycemia Detection Using Hand Tremors: Home Study of Patients With Type 1 Diabetes
Authors: Jahromi Reza , Zahed Karim , Sasangohar Farzan , Erraguntla Madhav , Mehta Ranjana , Qaraqe Khalid 
Published: February 2023

Background
Diabetes affects millions of people worldwide and is steadily increasing. A serious condition associated with diabetes is low glucose levels (hypoglycemia). Monitoring blood glucose is usually performed by invasive methods or intrusive devices, and these devices are currently not available to all patients with diabetes. Hand tremor is a significant symptom of hypoglycemia, as nerves and muscles are powered by blood sugar. However, to our knowledge, no validated tools or algorithms exist to monitor and detect hypoglycemic events via hand tremors.

Objective
In this paper, we propose a noninvasive method to detect hypoglycemic events based on hand tremors using accelerometer data.

Methods
We analyzed triaxial accelerometer data from a smart watch recorded from 33 patients with type 1 diabetes for 1 month. Time and frequency domain features were extracted from acceleration signals to explore different machine learning models to classify and differentiate between hypoglycemic and nonhypoglycemic states.

Results
The mean duration of the hypoglycemic state was 27.31 (SD 5.15) minutes per day for each patient. On average, patients had 1.06 (SD 0.77) hypoglycemic events per day. The ensemble learning model based on random forest, support vector machines, and k-nearest neighbors had the best performance, with a precision of 81.5% and a recall of 78.6%. The results were validated using continuous glucose monitor readings as ground truth.

Conclusions
Our results indicate that the proposed approach can be a potential tool to detect hypoglycemia and can serve as a proactive, nonintrusive alert mechanism for hypoglycemic events.
Characterization, antibacterial and anticancer study of silk fibroin hydrogel
Authors: Singh Vandana , Srivastava Devika , Pandey Prashant , Kumar Mukesh , Yadav Sachin , Kumar Dinesh , Venkatesh Kumar R. 
Published: February 2023

Purpose: Protein-based hydrogels such as silk fibroin hydrogel, are used in tissue engineering and regenerative medicine applications as they showed striking characteristics like biocompatibility and offered various benefits as biomaterials. The current study sought to prepare silk fibroin hydrogel and characterise it in order to assess its antibacterial and anticancer activity.
Methodology: Silk fibroin hydrogel was prepared and characterized by using different microscopy methods, namely Scanning Electron Microscopy (SEM), Phase Contrast Electron (PCM) microscopy, and foldscope analysis. Further, it was characterized through 1H-NMR analysis, Fourier Transform Infrared spectroscopy (FTIR) analysis, and swelling properties. A Current study also covers an antimicrobial and anticancer analysis of silk fibroin hydrogel by disk diffusion method and SRB (Sulforhodamine B) assay respectively.
Results: The antibacterial study confirmed that SF hydrogel has a moderate antibacterial activity for Streptococcus mutans, and Salmonella typhi. Additionally, the SRB assay test showed that silk fibroin hydrogels had moderate anticancer activity against the human lung cancer cell line (A549).
Conclusion: The current study unequivocally demonstrates that silk fibroin hydrogel has antibacterial and anti-cancerous properties, making it a suitable scaffold for future studies that seek to target a specific drug delivery site.
Keywords: Silk fibroin; Swelling behaviour; Anticancer; Drug carrier; Wound healing
Assessment of the Physico-Chemical Conformity of an Antiseptic Solution: Case of Polyvidone - Iodine 10%
Authors: CISSE Mody , BADIAGA Mamadou , DEMBELE Ousmane , OUATTARA K. Ibrahim , SANGARE Coumba Dite Astan , COULIBALY S. Moussa , SANGARE Modibo , TRAORE Nah , KOUMARE Y. Bénoit 
Published: February 2023

Introduction: Antiseptics have been used for many years in human and veterinary medicine. Over the years, the lengthening of surgical procedures in human surgery and the increasingly frequent use of inert material has increased the risk of infections. This was why skin antisepsis has become very important in the prevention of infections of the surgical wound and resulting complications. In Mali, at the Gabriel Touré University Hospital, the most prescribed family of antiseptics was the halogenated ones, in particular 10% povidone iodine for wound and surgical site antisepsis. This study was aimed to control the quality of 10% povidone iodine used in the hospital. Methodology: We conducted at the Medicines Quality Control Service of the National Health Laboratory of Mali (LNS) a retrospective analytical study on the quality control of 10% povidone iodine. We obtained 10% povidone iodine samples from the Pharmacie Populaire du Mali (PPM). We analyzed 48 batches of samples in regards of visual inspection, average volume, titrimetry, colorimetric test and pH control. Results: All 48 analyzed batches were compliant, i.e. contained the active ingredient and could be used in health facilities or at home as an antiseptic. Conclusion: All analyzed batches of 10% povidone iodine samples did not show any cases of inconsistency and therefore could be used in the management of wound dressings. Future Direction: Use other analytical methods like HPLC to test the quality control of povidone and other types of antiseptics.
Keywords: antiseptic, povidone-iodine 10%, compliance, quality control
Transdermal Drug Delivery Systems
Authors: Pasupuleti Prakash , Bandarapalle Kishore , Sandhya Cherlopalli , Neeraja Gundam , Afzal Chilakala , Venkataramana Chithrala , VenkatSai Golla 
Published: February 2023

A transdermal patch is a medicated adhesive patch that is applied to the skin that contains medication that is intended to be absorbed into the bloodstream. This frequently encourages the healing of a body part that has been hurt. Transdermal medication delivery allows for regulated drug release into the patient, resulting in less systemic side effects and, in certain cases, increased efficacy over other dose forms. This is an advantage of transdermal drug delivery over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. Transdermal medication delivery allows for a constant blood level profile, a regulated drug release into the patient, fewer systemic side effects, and other benefits.
Keywords: Transdermal patch, Blood stream, Systemic side effects.
Effect of the combination of Silybrum marianum and Lycopodium clavatum on some biological markers for monitoring chronic hepatitis B virus patients
Authors: ZEMO FOKOU Thierry Anicet , KANIA Dramane , TCHAKOUNTE Constantin , NYEGUE Ascension Maximilienne 
Published: February 2023

Viral hepatitis B is a disease for which no curative treatment is available to date. The objective of this study is to evaluate the effect of Silybrum marianum and Lycopodium clavatum preparations on the biological parameters of viral hepatitis B follow-up.
Material and methods: This was a longitudinal study of a period of 5 months. The study population consisted of consenting chronic hepatitis B patients. A questionnaire was used to collect sociodemographic information and medical history of the patients. One Step Rapid Test HBV-2210305 and Biolabo kits were used to test for serological parameters and transaminases. The viral load was determined using the real-time PCR technique. The decoctions were made from the leaves and rhizomes of Sylibum marianum associated with the floral juice of Lycopodium clavatum. The evaluation of the effect of the decoction was done by comparing the values of parameters between the beginning and after 3 months of treatments.
Results: Seven out of nine patients were chronically infected with the hepatitis B virus in active phase. After 90 days of treatment, we noted the persistence of AgHbs in all patients but a disappearance of AgHbe in 75% of patients. Mean transaminase activity and viral load decreased significantly after treatment (P=0.045).
Conclusion: The preparation of a decoction of Silybrum marianum and Lycopodium clavatum leads to normalization of Alanine Amino transferase activities (AAT), loss of HBe antigen and decrease of viral load after three months of treatment.
Keywords: Chronic hepatitis B, Silybrum marianum, Lycopodium clavatum, decoctions, transaminase activity and viral load.
A Case Report on Pulmonary Tuberculosis Associated with Deep Vein Thrombosis
Authors: Behera Sunil Kumar , Ali Syed Shoeb , Kummari Apoorva , Ahamad Shaik Khadeer , Shreya Arvini 
Published: February 2023

Public health problems such as tuberculosis remain a major concern, especially in developing countries. According to WHO (World Health Organization), for every second someone gets infected with tuberculosis. India is the second most populated nation in the world contributes to 23% of TB incident cases annually out of 9.6 million worldwide. The overall morbidity and mortality associated with TB are reduced with early initiation of anti-TB treatment. In India, most antituberculosis regimens are Rifampicin-based under the Revised National Tuberculosis Control Program (RNTCP). Despite its rarity, deep venous thrombosis (DVT) should be considered especially in those with severe disseminated or pulmonary tuberculosis. This case report describes a 31-year-old female with pulmonary tuberculosis initiated on rifampicin-based antituberculosis treatment presented with deep vein thrombosis.
Keywords: Tuberculosis, Deep vein thrombosis, pulmonary tuberculosis
Effect of Hydromethanolic Extract of Stem Bark of Lannea kerstingii on Anemia and Hepcidin Production
Authors: Magnang Hèzouwè , Kueviakoé Messanh Délagnon Irénée , Togbenou Komlatsè , Agbonon Amegnona 
Published: February 2023

Introduction: Stem bark of Lannea kerstingii is used in Togo for its anti-anemic effect. The aim of this study was to verify the efficacy of extracts of L. kerstingii’s bark in the treatment of anemia and to explore its mechanism of action. Materials and Method: L. kerstingii stem bark was collected in the city of Kpalimé, located at 120 km northwest of Lomé. Hydromethanolic extract was obtained by evaporation. Two protocols were carried out and 20 twelve-week-old rats that had an average weight of 175.17±16.8 grams were used. The first protocol consisted of inducing anemia in rats by intraperitoneal injection of phenylhydrazine, then force-feeding them with L. kerstingii extract and measuring the effect of this extract on their hemoglobin levels. The second protocol investigated the effect of the extract on the serum hepcidin level, after oral administration of carbon tetrachloride to rats. Hepcidin levels were measured by the ELISA technique. Results: L. kerstingii stem bark extract significantly corrected the anemia induced by phenylhydrazine use: in fact, the anemia of rats that received L. kerstingii extracts was corrected. Control rats that received folic acid had a correction of their anemia too. But, rats that received only saline remained anemic. However, no correlation between the level of extract consumption and the level of hepcidin was established. Conclusion: L. kerstingii bark hydroethanolic extracts increase hemoglobin levels in anemic rats. The main challenge that needs to be solved is determining the minimum dose to be consumed to ensure its effectiveness.
Keywords: Lannea kerstingii, anemia, hepcidin, wistar rat.
Estimations of Serum Creatinine, Urea, and Some Urine Parameters among Patients with Type 2 Diabetes Mellitus after More than Ten Years Disease Onset
Authors: Ahmed Mohammed Abdelsalam , Elmukashfi Salman Taha Ahmed , Ahmed Najah Abdelwahab 
Published: February 2023

Background: Assessment of a patient’s renal function may be used for two different purposes. One is to diagnose impaired renal function, and the other is to detect the presence of a progressive loss of renal function over time 1. In Sudan according to our knowledge there is lack of information regarding the impact of prolong type 2 diabetes mellitus on the renal function.
Objective: This study aims to assess renal function described as serum creatinine, urea and some urine parameters in type 2 diabetics after more than ten years onset. To detect impact of patient age and the duration on renal function.
Materials and methods: This study was designed as case control study, carried out in Northern State, Al Dabbah, during the period from Februarys to June 2014. Include 100 samples (57 males and 43 females), 50 samples collected from patient with more than ten years type 2 diabetic (27 males and 23 females) and 50 samples collected from healthy volunteers as pre described by physical examination and medical history (30 males and 20 females).
Results: The results showed statistically significant increase in the serum levels of creatinine and urea in diabetic compared to their copartner with p.value 0.000 and mean ± SD (3.29±2.25, 1.28±0.35) mg/dl and (63.88±3.38, 21.28±5.48) mg/dl for diabetic and non-diabetic respectively. urine parameters showed elevation and presence of albumin 35% in diabetic and 1% in non-diabetic, sugar 99% for diabetic and 0% in non-diabetic, acetone 60% for diabetic and 0% for non-diabetic, pus 55% for diabetic and 5% for non-diabetic, calcium oxalate 66% for diabetic and 1% for non-diabetic, RBCs 5% for diabetic and 2% for non-diabetic, yeast cells 2% for diabetic and 1% for non-diabetic, epithelial cells 11% for diabetic and 1% for non-diabetic.
Conclusion: There were significant increase in serum levels of creatinine and urea. And urine albumin, sugar, acetone, pus and calcium oxalate. Positive correlation between duration and urea and no correlation between duration and creatinine in case group. There were no significant changes in RBCs, yeast cells and epithelial cells. Patients should have regular screening renal function tests.
O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems
Authors: Sy Papa Mady , Dieng Sidy Mouhamed , Djiboune Alphonse Rodrigue , Soumboundou Mamadou , Cisse Fatou Diop , Dieme Mouskeba Sire , Ndong Boucar , Diouf Louis Augustin Diaga , Mbaye Gora , Mbodj Mamadou , Diarra Mounibé 
Published: February 2023

This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing particles composed of magnesium carbonate particles. Pickering oil-in-water emulsions stabilized with magnesium carbonate particles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of magnesium carbonate particles on the physicochemical properties of Pickering emulsions. The O/W Pickering emulsion was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by magnesium carbonate particles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and magnesium carbonate particles allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.
Keywords: emulsion -Pickering-magnesium carbonate- ibuprofen-oral bioavailability
Prophylactic aspects and therapeutic potential of Turbud (Operculina turpethum L) in Unani medicine: An evidence-based appraisal
Authors: Bashir Fouzia 
Published: February 2023

Abstract
Turbud (Operculina turpethum L.) belongs to the family Convolvulaceae, a potent and well-known medicinal herb, used in Unani system of medicine to treat several diseases. It is a large perennial twinner with milky juice. Roots are long, slender, fleshy, and much branched. In classical text it is mentioned that the Turbud which is white in colour, light weighted and having resin on both ends is of good quality. In Unani system of medicine, its main actions are expectorant and laxative and used in several diseases like arthritis, ascites, gout, hemiplegia etc. According to Ibn Sina use of Turbud along with zanjabeel is more effective. It has been used as an important component in many compound formulations such as Itrifal Ustu-khud’dus, Itrifal Zamani, Itrifal Muqil, Itrifal Mulaiyyin. The major chemical constituents present are turpethin, glucoside, jalapine, convolvulin etc. Operculina turpethum L. is validated for its different pharmacological actions like anti-inflammatory effect, and ulcer protective etc. The present review comprehensively embodied its phytochemical, pharmacological and pharmacognostic description.