bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of sialic acid content in bovine and buffalo milk and meat
Authors: Contò Michela , Rinaldi Simona , Failla Sebastiana 
Published: January 2025

Animal-origin food, such as meat and milk, are important sources of sialic acids (SIAs) with relevant implications for human health. Two significant SIAs in mammals are N-acetyl-neuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu-5Gc). Neu5Ac is the major form of SIAs in all mammalian tissues, and it is an essential nutrient for the development and function of the brain. Neu5Ac differs from Neu5Gc by a single oxygen atom, but humans cannot synthesize the Neu5Gc due to a genetic mutation. Thus, Neu5Gc causes a human antibody response, which promotes the inflammatory processes. On the other hand, animal products are excellent sources of Neu5Ac, which has a high nutritional value. A diet with Neu5Ac/Neu5Gc ratio higher than 5 is recommended to inhibit the absorption of Neu5Gc. This ratio is rarely reached in red meat, so it is considered potentially carcinogenic. This study aimed to determine the concentrations of Neu5Ac and Neu5Gc in the milk and meat of buffalo and cattle and to evaluate the ratio of Neu5Ac/Neu-5Gc. The study was conducted on 12 bulk milk and 12 samples of Longissimus thoracis for each species. Samples were collected from Friesian bovine and buffalos raised in farms located in Central Italy. The concentration of the two types of SIAs was determined by the reverse phase (RP) high-performance liquid chromatography (HPLC) procedure of SIAs released from glycoconjugates through acidic hydrolysis and derivatized with 1,2-diamino-4,5methylen- edioxy-benzene (DMB). Data was analyzed by ANOVA using a bifactorial model with interactions (products and species). Both products and the species influenced the content of Neu5Ac (p<0.001 and p<0.014, respectively) and Neu5Gc (p<0.001, for both). Neu5Ac content was significantly higher in buffalo milk than in cow milk (1045 vs. 906 μg/g protein). In contrast, Neu5Gc content was significantly lower in buffalo milk than in cow milk (58 vs. 106 μg/g protein). On the contrary, there was no significant difference in Neu5Ac meat content in the two species (473 μg/g protein, on average). In contrast, Neu5Gc content was significantly higher in cattle meat than in buffalo meat (228 vs. 83 μg/g protein p<0.001). Buffalo products showed a Neu5Ac/Neu5Gc ratio greater than 5 (18.5 for milk and 6.4 for meat), while beef meat had a ratio of 2.2 (less than 5). In conclusion, due to the high amount of Neu5Ac and the limited presence of Neu5Gc, buffalo products could have an exciting effect on human health.
Hemolytic activity of saponins from the leaves and stems of the specie Boldoa purpurascens Cav., determined by HPLC – UV: Validation of the method
Authors: González-Mosquera Dulce María , Hernández-Ortega Yannarys , Orellana-Rodríguez Eliannet , Ojeda-González Idalmis Karina , Gigante-Silva Matheus , Quero-Jiménez Pedro César 
Published: January 2025

This research contributes on the chemical composition of the species Boldoa purpurascens Cav. although the identification, quantification, and hemolytic activity evaluation of saponins isolated from this specie, moreover, high-performance liquid chromatography - ultraviolet detection (HPLC - UV) methodology has been developed and validated. To determine the saponin content of Boldoa purpurascens Cav. hydroalcoholic extract, a HPLC – UV was used. A Quil-A® pattern has been used to evaluate the validation parameters, such as method linearity, limits of detection and quantification, precision, accuracy, selectivity, and specificity. The research showed that each target component was well-separated under the optimal analytical settings with great selectivity. The technique was found to be precise, accurate, and repeatable. The method's linearity was determined to be robust, with an excellent determination coefficient value (R2≥0.999). The evaluation of the matrix effect revealed that each target component had a high degree of selectivity and was well-separated. It could be inferred that the established HPLC-UV methodology is accurate and useful for identifying saponins in the hydroalcoholic extract of Boldoa purpurascens Cav. The hydroalcoholic extract of Boldoa purpurascens Cav. was used to quantitatively determine the saponin content, and it was discovered that the concentration of QS 7 in the 80% hydroalcoholic extract was 1.9 x 10-2 g L-1 in the stem whereas 1.6 x 10-2 g L-1 in the leaves. The Boldoa purpurascens Cav. saponins have hemolytic activity comparable to Quil-A®, as shown by a thin layer chromatographic hemolysis experiment.
Chemical composition, antioxidant and antimicrobial activities of the essential oil of Eudema nubigena Humb. & Bonpl.
Authors: Moncayo-Molina Luis , Rojas-Molina Jaime O. , Pino Jorge A. , Spengler Iraida , Moncayo-Rivera Christian M. 
Published: January 2025

The chemical composition, antioxidant and antimicrobial activities of the essential oil from the aerial parts (leaves and flowers) of Eudema nubigena Humb. & Bonpl. were analyzed. The analysis of the essential oil was done by gas chromatography with flame ionization detector (GC-FID) and gas chromatography with mass spectrometry detector (GC-MS). A total of 131 compounds, representing 99.2% of the essential oil, were identified. The chemical profile revealed a high content of oxygenated monoterpenes (37.8%), monoterpene hydrocarbons (27.7%) and aliphatic compounds (17.3%). The major compounds were camphor (19.5%), myrcene (11.3%) and undecan-2-one (10.2%). The antioxidant activity of the essential oil, evaluated by DPPH and ABTS assays, exhibited a weak ability in scavenging radicals. The essential oil also showed a low ferric reducing activity. The essential oil exhibited good activity against C. albicans, but low activities against S. aureus, E. coli, S. enterica serovar, and P. aeruginosa.
Blended professional teaching of Internal Medicine in third-year medical students
Authors: Alonso Betancourt Luis Aníbal , Silva Velasco Edilio , Velázquez González Verónica Aleyda , Vidal Gámez Luis Enrique , Vidal Rodríguez Anisleidy , García González Maryuri , García Hernández Adelin 
Published: January 2025

Introduction. Conceiving the teaching of Internal Medicine in the post-pandemic era in the third-year medical student presupposes taking into consideration the latest scientific and technological advances that operate in therapeutic diagnostic protocols for the solution of health problems, as well as the use of combined professional teaching methods (b-Professional Teaching) under the principle of affordability of content.Objective. To propose a methodology for combined professional teaching of Internal Medicine in third-year Medicine students. Methods: A cross-sectional quasi-experimental study was carried out. The population was made up of third-year medical students who rotate through the Hospital.Methods. A cross-sectional quasi-experimental study was carried out. The population was made up of third-year medical students who rotate through the “Vladimir Ilich Lenin” University General Hospital of Holguín. Groups 1 and 3 were selected as a sample because they presented similar results in their clinical training through intentional sampling, for a total of 54. Observation and the Wilcoxon Signed Rank Test were used to confirm the research hypothesis. Results. The combined professional teaching methodology of Internal Medicine was provided, as well as the main achievements and deficiencies that the Medical students demonstrated during the application of the same in a training period. Conclusions. The combined professional teaching of Internal Medicine is conceived through the affordability of the content according to the characteristics of the third-year student and is materialized through the link between thez academic, work and research component based on the integration of face-to-face and virtual teaching (virtual classrooms and mobile devices).
Clinical and epidemiological characterization of patients with ischemic heart disease and left ventricular dysfunction
Authors: Mesa Valiente Rita María , Turro Caró Eloy , Turro Mesa Lucia Nivia , Caballero Germán Del Río , Del Río Mesa Germán Ricardo , Montes de Oca Carmenaty Margarita 
Published: January 2025

Introduction: One of the most common causes of heart failure is ischemic heart disease. Objective: To characterize patients with a diagnosis of ischemic heart disease and left ventricular dysfunction from an epidemiological and clinical point of view.Methods: Observational, descriptive and cross-sectional study in a population of 300 patients with a diagnosis of ischemic heart disease and left ventricular dysfunction, treated in the cardiology service of the Saturnino Lora Torres Provincial Clinical Surgical Teaching Hospital, from January 2021 to December 2023. The summary measures were applied for each type of variable, in each statistical test a significance level α=0.05 was used. Results: 53.3% of the patients were in the age group of 60 to 79 years and 66.0% were male. A significant statistical association was found between the presence of pulmonary edema and systolic-diastolic dysfunction of the left ventricle; as well as cardiogenic shock, sustained ventricular arrhythmias, stroke and pulmonary embolism with the status at discharge. Conclusions: Patients with a diagnosis of ischemic heart disease and left ventricular dysfunction were characterized by advanced age, disparity in the proportion between sexes. The presence of pulmonary edema was secondary to systolic-diastolic dysfunction of the left ventricle. Patients with negative coronary angiography, cardiogenic shock, sustained ventricular arrhythmias, stroke, and pulmonary embolism were associated with discharge status.
Immunological aspects of COVID-19 pathogenesis: a review
Authors: Miló Valdés Carlos Alfredo , Pérez Acevedo Lidia Cecilia 
Published: January 2025

Introduction: COVID-19, caused by SARS-CoV-2, has challenged the scientific and medical community since its emergence. Understanding the immunopathogenic events that occur during infection is crucial to developing effective treatment and prevention strategies.Objective: To synthesize the immunological aspects in the pathogenesis of coronavirus disease 2019.Development: SARS-CoV-2 infection begins with the entry of the virus into host cells through the ACE2 receptor. Once inside, the virus induces an immune response. In the early stages, the innate immune response is activated, which includes the release of interferons and cytokines. However, in some patients, this response becomes deregulated, triggering a cytokine storm that contributes to systemic inflammation and lung damage. T and B cells also play a crucial role; although the activation of CD8+ T cells can help control the infection, their depletion in severe cases has been associated with worse clinical outcomes. Conclusions: Immunopathogenic events in COVID-19 are complex and can lead to diverse clinical outcomes. Understanding these mechanisms is essential for the development of targeted therapies and effective vaccines. Continued research is critical to improving our response to future pandemics.
Patients' characterization affected with cervicalgia assisted in the Services of Integral Rehabilitation
Authors: Borrero Terrero Yoanky , Vianka Lisandra González Montalván , Ordoñez  Álvarez Lázaro Yoan , González Sardabu Lidiuska Gladys , Hernández Ávila Frank 
Published: January 2025

Introduction: the cervicalgia constitutes the clinical entity that refers to the pain located in the later region and posterolateral of the neck, from the occiput until the high dorsal region. Objective: to characterize clinical and therapeutically the patients affected with cervicalgia assisted in the room of rehabilitation of the Center Diagnosis Integral School The Olive trees in the state of Bolivar, in the period of January to June 2024. Methods: he/she was carried out an observational study, analytic of cohort, longitudinal and prospective that included the patients affected with cervicalgia assisted in the room of rehabilitation of the Center Diagnosis Integral School The Olive trees. Results: in relation to the distribution of patient according to sex, it is observed that the feminine sex prevailed with 75,7%, the etiología of the most frequent cervicalgia in the individuals of the study was the mechanics with 73,6%. Conclusions: they were characterized clinical and therapeutically the patients affected with cervicalgia assisted in the rehabilitation room where the women constitute the most representative sex, being more frequent the entity in the adult associated to mechanical causes
Immuno-nutritional and insulin-resistance markers associated with severe perioperative complications after cardiac surgery
Authors: el Río Caballero Germán , Turro Mesa Lucía Nivia , Del Río Mesa Germán Ricardo , Mesa Valiente Rita María , Turro Caró Eloy 
Published: January 2025

Introduction: The progress of cardiac surgery that has been parallel to technological development has not been able to sufficiently counteract the high morbidity and mortality of cardiovascular surgical patients and their high costs; for this reason, the search for markers that can predict adverse effects and post-surgical complications in time and facilitate a better evaluation of these patients continues. Objective: to evaluate the degree of association of new immuno-nutritional and insulin-resistance biomolecular markers with the appearance of serious perioperative complications.Methods: An ambispective cohort study was carried out on patients who underwent major cardiovascular surgery between January 1, 2019 and December 31, 2023 at the Cardiocentro of Santiago de Cuba, who met inclusion criteria. Results: A significant association was found between immuno-nutritional and insulin resistance biomarkers and severe perioperative complications: triglyceride-glycemia index (p=0.000 RR 5.23), leuko-glycemic index (p=0.000 RR 7.76), nutritional prognostic index (p=0.004 RR 2.56), albumin/globulin ratio (p=0.050 RR 0.338).Conclusions: A close link is demonstrated between the new biomarkers selected and severe perioperative complications, so their inclusion in the preoperative assessment could facilitate earlier monitoring, diagnosis and treatment of complications and reduce morbidity and mortality in these patients
Strategy of professional superacion on Natural and Traditional Medicine in the Primary Attention of Health
Authors: Blanco Fuentes Rosa Marila , Ramos Vives Madelaime , Ramos Padilla Kenia , García Pérez Marleidy , Soberao Rodríguez Lidiana 
Published: January 2025

Introduction: In Cuba, where it is high-priority the Primary Attention of Health, you intenciona a system of permanent superación directed to the professionals to guarantee the quality of the service of health, from this perspective, the concept superación of the primary attention of health is identified many times with training, formation and development. Objective: to elaborate a strategy that contributes to the improvement of the process of professional superación on Natural and Traditional Medicine in the Primary Attention of Health that allows the specialist's efficient acting in Family Medicine in the Policlínico University Siblings Cruz of Pinegrove of the River. Methods: the investigation was sustained in the materialistic dialectical focus that bases the study of the object like process, and that it allowed to deepen in the knowledge of the object and its interrelations under the social historical conditions of the graduate degree education it has more than enough Natural and Traditional Medicine in the specialist in Family Medicine, to reveal its main contradictions, to select, to base and to integrate the theoretical, empiric and statistical methods. The selected variable is process of professional superación on Natural and Traditional Medicine. Results: the strategy of professional superación is presented on Natural and Traditional Medicine in the primary attention of health with base in the theoretical and empiric derivations of the investigative process and starting from foundations sustained in different areas of the knowledge, they intend the structure, characteristics, components and relationships for the process in study and its theoretical validation. Conclusions: in the strategy of professional superación on Natural and Traditional Medicine in the primary attention of health the purposes were summed up to achieve the specialist's efficient acting in Family Medicine, in the transformation of the reality in the area of health of the Policlínico University Siblings Cruz of Pinegrove of the River
Didactic pamphlet for the work with the address abilities from the docencia
Authors: González Sardabu Lidiuska Gladys , Ordoñez  Álvarez Lázaro Yoan , Curbelo Fajardo Juan Carlos , Ramírez Pérez Noelvis , Gil Figueroa Bertha Vivian 
Published: January 2025

Introduction: the formation and development of the squares should be conditioned for political and strategies of the organization. The public health, needs that the preparation and the development of their directive are in function of responding to the necessities of the plans, programs and national strategies of health. Objective: to implement a didactic pamphlet that he/she responds to the necessity of training of the squares and reservations in the Cuban medical mission in Venezuela, state of Bolivar. Development: the present investigation, takes like methodological base of the scientific knowledge, to the dialectical-materialistic method serving from base to the objective character of the inquiry process científica.La validation and implementation of the pamphlet like didactic tool to use in the courses and training of squares and reservations, approach was obtained of good for 93,2% of the total of experts. Conclusions: with their implementation a logical order of the actions that requires the preparation of the educational ones that you/they impart the training of the squares and reservations in the Cuban medical mission in Venezuela, state of Bolivar starting from the foundations and approaches emitted by the indexed investigators, settled down as well as the amplification of essential components of the knowledge that you contextualizan in the current realities
Top team effectiveness and how to develop it
Authors: Beer Michael 
Published: January 2025

Top team effectiveness and how to develop it
Dr Michael (Mike) Beer, Professor Emeritus from Harvard Business School, explains top team effectiveness and how to develop it. Organizations have tops, middles, bottoms, and customers. (1) They are hierarchies that must serve customers well to survive and prosper. The role of top teams is to define the enterprise’s strategic direction and ensure it is organized, managed, and led to execute that direction effectively. Yet, top teams too often do not fulfill their role effectively. We know this from 30 years of work with hundreds of organizations whose leaders have come to me and my colleagues at TruePoint, a consulting firm composed of scholar-consultants, for help.
Predicting cochlear implant performance: Moving beyond single biomarkers and leveraging artificial intelligence
Authors: Shew Matthew , Buchman Craig A , Walia Amit 
Published: January 2025

Predicting cochlear implant performance: Moving beyond single biomarkers and leveraging artificial intelligence
Matthew Shew, Amit Walia, and Craig A. Buchman highlight that the significant variability in speech perception among cochlear implant users can be addressed by using a multi- faceted approach that incorporates emerging technologies like machine learning and artificial intelligence to improve outcome prediction models. Cochlear implants (CIs) represent one of the most successful neural prostheses, providing discrete frequency and intensity electrical stimulation to restore hearing, improve speech understanding, and enhance quality of life. Despite their transformative impact, a significant challenge remains: the substantial variability in speech perception outcomes among CI users. (1) While current methodologies excel at identifying individuals with severe hearing loss and, thus, strong CI candidates, they fall short in predicting the degree of benefit each recipient will gain from the device. This limitation hinders personalized care and underscores the need for more advanced predictive tools.
The future of green tech: Self-powered IoT sensors
Authors: Staaf Henrik 
Published: January 2025

The future of green tech: Self-powered IoT sensors
Discover the future of green technology and self-powered IoT sensors, as explained by Henrik Staaf from RISE Research Institutes of Sweden. As sustainability becomes a global priority, self-powered Internet of Things (IoT) sensors are transforming the way technology integrates with our lives. These innovative devices harvest energy from their surroundings, allowing them to function without batteries. This breakthrough not only enables real-time monitoring but also significantly reduces environmental impact, paving the way for smarter, greener systems.
Echo’s citizen science initiatives for soil literacy take off
Authors: Peiro Alba , Cappello Claudia , Laurent Céline , Sanz Francisco , Papadopoulou Elisavet , Mimmo Tanja 
Published: January 2025

Echo’s citizen science initiatives for soil literacy take off
Led by ECHO partners, we hear about citizen science initiatives that aim to improve soil literacy and foster sustainable practices through workshops and community engagement. Citizen science has a long-standing history across Europe as a significant tool for addressing environmental issues by raising awareness and promoting best practices. Over the past 15 years, citizen science projects focusing on soils have gained significant traction, driven by a growing awareness of environmental issues and the integration of soil health into political agendas. A key initiative in this direction is the European Soil Observatory (EUSO), a platform that monitors soil health and related policies to enhance soil protection. It integrates soil health data that can be further enriched by citizen-generated data collected through citizen science initiatives, such as the European project ECHO.
Decarbonising the textile industry: A revolutionary pigment from the lab to the market in three years
Authors: Durand Victor 
Published: January 2025

Decarbonising the textile industry: A revolutionary pigment from the lab to the market in three years
Explore the journey of decarbonising the textile industry through the remarkable example of bringing a revolutionary pigment from the lab to the market in three years, starting with the milestones of this captivating journey. EverDye is a green chemistry startup aiming at decarbonizing the way we colour our garments. Its journey began with a vision to revolutionise textile dyeing, one of the most impactful steps of textile production. Along the way, the company achieved milestones that validated the impact and scalability of its innovation. Each step marked a significant leap toward creating a sustainable solution for the textile industry, free from intensive resource utilisation.
Understanding electromagnetic hypersensitivity (EHS)
Authors: Bevington Michael 
Published: January 2025

Understanding electromagnetic hypersensitivity (EHS)
Electromagnetic hypersensitivity: Michael Bevington, Chair of Trustees at Electrosensitivity UK, explains the health risks associated with exposure to radiofrequency radiation and electromagnetic fields and why more robust action is needed to protect public health. Electromagnetic Hypersensitivity (EHS) is a physical reaction to radiofrequency radiation (RFR) and electromagnetic fields (EMFs). These come from mobile phone masts, mobile phones, Wi-Fi, Bluetooth, smart meters, and similar devices, as well as power lines and electric motors. Typical short-term symptoms are headaches, dizziness, brain fog, memory loss, muscle pains, heart palpitations, anxiety, depression, nosebleeds and skin rashes. Long-term symptoms, often subconscious, range from cancer and infertility to neurological and cardiovascular harm.