bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of traditional Chinese exercise for the treatment of pain and disability on knee osteoarthritis patients: a systematic review and meta-analysis of randomized controlled trials
Authors: Zhang Shuaipan , Huang Ruixin , Guo Guangxin , Kong Lingjun , Li Jianhua , Zhu Qingguang , Fang Min 
Published: June 2023

ObjectiveTo evaluate the efficacy of Traditional Chinese Exercises (TCEs) in treating knee osteoarthritis (KOA).MethodsFour databases without language or publication status restrictions were searched until April 1, 2022. Based on the principle of Population, Intervention, Comparison, Outcomes and Study design, the researchers searched for randomized controlled trials of TCEs in treating KOA. The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain was defined as the primary outcome, whereas stiffness and physical function were the secondary outcomes. Subsequently, two researchers conducted the process independently, and the data were analyzed using the RevManV.5.3 software.ResultsOverall, 17 randomized trials involving 1174 participants met the inclusion criteria. The synthesized data of TCEs showed a significant improvement in WOMAC pain score [standardized mean difference (SMD) = −0.31; 95% confidence interval (CI): −0.52 to −0.10; p = 0.004], stiffness score (SMD = −0.63; 95% CI: −1.01 to −0.25; p = 0.001) and physical function score (SMD = −0.38; 95% CI: −0.61 to −0.15; p = 0.001) compared with the control group. Sensitivity analyses were performed to determine the combined results' stability, which was unstable after excluding articles with greater heterogeneity. A further subgroup analysis showed that it might be the reason for the heterogeneity of the different traditional exercise intervention methods. Additionally, it showed that the Taijiquan group improved pain (SMD = 0.74; 95% CI: −1.09 to 0.38; p &lt; 0.0001; I2 = 50%), stiffness (SMD = −0.67; 95% CI −1.14 to 0.20; p = 0.005) and physical function score (SMD = −0.35; 95% CI: −0.54 to 0.16; p = 0.0003; I2 = 0%) better than the control group. The Baduanjin group improved stiffness (SMD = −1.30; 95% CI: −2.32 to 0.28; p = 0.01) and physical function (SMD = −0.52; 95% CI: −0.97 to 0.07; p = 0.02) better than the control group. However, the other interventions showed no difference compared with the control group.ConclusionThis systematic review provides partial evidence of the benefits of TCEs for knee pain and dysfunction. However, due to the heterogeneity of exercise, more high-quality clinical studies should be conducted to verify the efficacy.Systematic review registrationhttps://inplasy.com/inplasy-2022-4-0154/, identifier: International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY) [INPLSY202240154].
Translation and cross-cultural adaptation of the Work Rehabilitation Questionnaire (WORQ) into Danish
Authors: Thygesen Katrine Baltzer , Korshøj Mette , Verpe Ida Skovgaard , Vestergaard Lise , Escorpizo Reuben , Mortensen Ole Steen 
Published: June 2023

PurposeThis study aimed to translate and cross-culturally adapt the work rehabilitation questionnaire (WORQ) into Danish to examine the internal consistency and test-retest reliability of the Danish WORQ and, second, to test the feasibility of WORQ in the Danish context of vocational rehabilitation.MethodsThe translation was performed in a dual-panel approach. The panel consisted of a bilingual physician, a university student in psychology, a layperson, a specialist in social work and rehabilitation, and a professor in social medicine. The international classification of functioning, disability, and health (ICF) codes were cross-evaluated to secure that there was a high level of agreement of ICF codes for each specific WORQ item in the Danish and English version. The content validity was evaluated by the clinical physicians at an outpatient clinic in social medicine and by the case managers at a municipality job center. Data for the examination of the internal consistency and test-retest reliability were collected at the Holbæk municipality from citizens in the working age. The test-retest took place 14 days apart. The internal consistency and test-retest reliability were tested conducting Cronbach's alpha, intraclass correlation, and Spearman’s correlation analyses.ResultsThe panel experienced only minor challenges in the translation process, leading to minor modifications. The cross-evaluation of coding in the Danish WORQ compared with the initial English version only found small deviations, while the remaining coding agreed between the initial English and the Danish items. The panel argued to add sub-codes to culturally adapt to the transportation forms generally used in Denmark. The general perception among the participating patients and citizens at the job center as well as the clinical physicians and case managers was that the WORQ was easy, understandable, and meaningful.ConclusionsThis study showed that the Danish WORQ have a high content validity and usability. Nonetheless, the Danish WORQ needs to be validated against well-acknowledged tools for assessing functional ability specific to work and in general.
Gender representation in animal-related proverbs: Algerian vs. Jordanian Arabic
Authors: Madani Zoubida , Abusalim Nimer , Rayyan Mohammad 
Published: June 2023

IntroductionThis study explores the connotative meanings in animal-related proverbs used to describe the behavior of men and women in Algerian and Jordanian societies.MethodsA questionnaire with 46 Algerian and 45 Jordanian animal-related proverbs was distributed to 30 native Arabic speakers enrolled at the University of Jordan. The analysis focused on adapted categories with a gender perspective, including inferiority, weakness, stupidity, ill-nature, objectification, ugliness, positivity, and shrewdness.ResultsBoth Algerian and Jordanian animal-related proverbs exhibited diverse connotative meanings. Women were predominantly associated with derogatory connotations in both languages, portraying characteristics such as weakness, stupidity, inferiority, cunningness, and trickery. Similar characteristics were present in descriptions of men, but women in Arab cultures were consistently depicted as subordinate and denigrated. Conversely, men were portrayed with authority, control, superiority, and strength over women. Additionally, positive depictions included animals like gazelles, peacocks, partridges, cats, and horses to symbolize the beauty of women. Men's positive characteristics, such as strength, courage, and superiority, were associated with horses, camels, and lions.DiscussionThis study highlights the prevalent connotations in animal-related proverbs used to describe men and women in Algerian and Jordanian societies. It reveals derogatory portrayals of women, reinforcing their subordinate status, while men are depicted with authority and power. However, positive representations emerged, attributing beauty to women and highlighting admirable qualities in men. These findings shed light on the complex dynamics of gender portrayal within cultural proverbs, emphasizing the need for further examination of these linguistic expressions.
Tyrosine kinase inhibitors as an alternative treatment in canine mast cell tumor
Authors: Coelho Yasmin Nascimento Bernardes , Soldi Luiz Ricardo , Silva Paulo Henrique Rosa da , Mesquita Caio Melo , Paranhos Luiz Renato , Santos Thaísa Reis dos , Silva Marcelo José Barbosa 
Published: June 2023

The current gold standard treatment for canine mast cell tumors (MCT) uses vinblastine sulfate (VBL) as chemotherapy, although tyrosine kinase inhibitors (TKI) have recently been shown to be worthy candidates for treatment. This systematic review aimed to analyze the overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and complete (CR) or partial response (PR) in dogs with MCT treated with TKI compared to standard VBL treatment. The systematic review was registered in the Open Science Framework (OSF) database under the identifier 10.17605/OSF.IO/WYPN4 (https://osf.io/). An electronic search was performed in nine databases. References from eligible studies were also selected to find more registers. A total of 28 studies met the eligibility criteria, and one more was recovered from the references of eligible studies, totaling 29 selected studies. The overall response rate, complete response, and partial response were higher in dogs treated with tyrosine kinase inhibitors than in dogs treated with vinblastine. The overall survival and progression-free survival of vinblastine-treated dogs were higher compared to tyrosine kinase inhibitors-treated dogs. Dogs with mutated KIT treated with tyrosine kinase inhibitors have longer overall survival and progression-free survival compared to those treated with vinblastine. It is important to consider the limitation of the study which should temper the interpretation of the results, videlicet, the extracted data lacked sample standardization and included variables such as animal characteristics, mutation detection methods, tumor characteristics, and treatment types which may have influenced the outcome of the study.Systematic review registrationhttps://osf.io/, identifier: 10.17605/OSF.IO/WYPN4.
Linear and multivalent PEGylation of the tobacco mosaic virus and the effects on its biological properties
Authors: Caballero Reca Marian , González-Gamboa Ivonne , Craig Stephen L. , Steinmetz Nicole F. 
Published: June 2023

Plant virus-based nanoparticles (VNPs) offer a bioinspired approach to the delivery of drugs and imaging agents. The chemical addressability, biocompatibility, and scalable manufacturability of VNPs make them a promising alternative to synthetic delivery platforms. However, VNPs, just like other proteinaceous or synthetic nanoparticles (NPs), are readily recognized and cleared by the immune system and mechanisms such as opsonization and phagocytosis. Shielding strategies, such as PEGylation, are commonly used to mitigate premature NP clearance. Here, we investigated polyethylene glycol (PEG) coatings on the tobacco mosaic virus (TMV), which was used as a model nanocarrier system. Specifically, we evaluated the effects of linear and multivalent PEG coatings at varying chain lengths on serum protein adsorption, antibody recognition, and macrophage uptake. Linear and multivalent PEGs of molecular weights 2,000 and 5,000 Da were successfully grafted onto the TMV at ≈ 20%–60% conjugation efficiencies, and the degree of cross-linking as a function of PEG valency and length was determined. PEGylation resulted in the modulation of TMV–macrophage interactions and reduced corona formation as well as antibody recognition. Linear and multivalent PEG 5,000 formulations (but not PEG 2,000 formulations) reduced α-TMV antibody recognition, whereas shorter, multivalent PEG coatings significantly reduced α-PEG recognition—this highlights an interesting interplay between the NP and the PEG itself in potential antigenicity and should be an important consideration in PEGylation strategies. This work provides insight into the PEGylation of VNPs, which may improve the possibility of their implementation in clinical applications.
Genomic Assessment of Enterobacter mori AYS9: A Potential Plant Growth-Promoting Drought-Resistant Rhizobacteria
Authors: Fadiji Ayomide Emmanuel , Ayangbenro Ayansina Segun , Babalola Olubukola Oluranti 
Published: June 2023

Drought stress poses a serious danger to agricultural production. Recent studies have revealed that most of the chemical methods used in the mitigation of its effects on plant production pose a serious threat to humans and the environment. Therefore, the demand for ecologically friendly solutions to ensure the security of the world’s food supply has increased as a result. Plant growth-promoting rhizobacteria (PGPR) treatment may be advantageous in this situation. Enterobacter mori is a promising rhizobacteria in this regard. However, information on the genome analysis of E. mori linked to the rhizosphere soil of the sorghum plant has not been extensively studied. In this study, we present a genomic lens into functional attributes of E. mori AYS9 isolated from sorghum plants, as well as assess its drought tolerance and plant growth-promoting potentials. Our results showed the drought tolerance and plant growth-promoting potentials of the AYS9. Whole genome sequencing (WGS) results revealed that the genome yielded 4,852,175 bp sequence reads, an average read length of 151 bp, 1,845,357 bp genome size, 67 tRNAs, 3 rRNAs, and a G + C content of 55.5%. The functional genes identified in the genome were linked to processes including phosphate solubilization, iron transport, hormone regulation, nitrogen fixation, and resistance to oxidative and osmotic stress. Also, secondary metabolites supporting bacterial biocontrol properties against phytopathogens, and abiotic stress such as aerobactin-type non-ribosomal peptide siderophore, Stewartan-type ladderane, and Colicin type NRPS were discovered in the AYS9 genome. Our findings however establish that the intricate metabolic pathways mediated by the projected new genes in the bacterial genome may offer a genetic foundation for future understanding of rhizosphere biology and the diverse roles that these genes play in plant development and health.
Malocclusion predictors in children with primary dentition (part one)
Authors: Danilova M. A. , Ishmurzin P. V. , Rudavina T. I. 
Published: June 2023

Relevance. The evaluation of malocclusion risk factor impact in primary dentition is an essential tool for prevention and treatment planning and high-quality child orthodontic care.The study aimed to determine malocclusion predictors in children with primary dentition.Material and methods. The article presents the retrospective dental status analysis findings of 123 children (55 boys and 68 girls). The initial oral examination was at 4.0 to 55 years old (average age was 5.1 ± 0.6 years), and the reexamination was at 6.0 to 10.5 years old (average age was 8.7 ± 1.3 years). We evaluated the presence of a relationship and its strength between the risk factors in primary dentition and malocclusion in early mixed dentition using Pearson's chi-squared test (χ2) and Kramer–Welch criterion (V). The study calculated the odds ratio with a 95% confidence interval for each pair of primary dentition risk factors – early mixed dentition malocclusion.Results. Differentiation of predisposing factors and their combination analysis allowed the formation of predictor clusters for primary dentition with the clinical probability of malocclusion in the mixed dentition of over 95%. For distal occlusion, the risk factor cluster included early extraction of lower deciduous molars, mouth breathing and postural disorder (χ2 = 11.46, V = 0.47); for mesial occlusion – early extraction of upper deciduous incisors and upper deciduous molars (χ2 = 18.30, V = 0.53); for deep overbite and open bite – early extraction of lower deciduous molars and reverse swallowing (χ2 = 14.61, V = 0.56); for an anterior open-bite – interdental lisp and sucking habits (χ2 = 20.91, V = 0.50); for the mandibular lateral shift – unilateral extraction of lower molars and mouth breathing (χ2 = 9.98, V = 0.42).Conclusion. Malocclusion predictor identification and elimination in children with primary dentition reduce the likelihood of malocclusion formation in mixed dentition.
Features of the development of experimental nephropathy in rats during the use of doxorubicin
Authors: Zverev Ya. F. , Motin Yu. G. , Mazko O. N. , Mozgunova N. A. , Motina N. V. 
Published: June 2023

BACKGROUND. One of the most frequently reproduced models of NS is doxorubicin (adriamycin) nephropathy in rats. However, the mechanisms of its development remain insufficiently studied, and it is not entirely clear to which form of NS the nephrotoxicity induced by doxorubicin should be attributed.THE AIM. Reproduction of doxorubicin nephropathy in rats in an attempt to morphologically identify the resulting pathology and determine the role of free radical oxidation (FRO) in the development of this model of nephrotoxicity.MATERIALS AND METHODS. Nephropathy was reproduced by a single intravenous administration of doxorubicin to male Wistar rats. In the urine, the content of creatinine, daily proteinuria, and albumin release were determined. Histological examination of the kidneys was performed using a Libra 120 electron microscope (Carl Zeiss, Germany). The total prooxidant activity, total antioxidant activity, the concentration of thiobarbiturate-reactive products, and the activity of antioxidant enzymes were assessed in the blood and kidney.RESULTS. Against the background of a gradual decrease in the glomerular filtration rate, a significant consistent increase in protein excretion was recorded, largely due to an increase in albumin excretion. Electron microscopic examination revealed a decrease in the number of small (foot) processes of podocytes, their fusion, sclerotic lesions of the elements of the capillary glomerulus, thinning of the GBM, sclerosis of the interstitium. There was a sharp activation of blood OPA and an increase in the content of TBRP. At the same time, such fast-responding antioxidant enzymes as CAT and SOD were activated. The blood TAA decreased in parallel with the decrease in GPO activity.CONCLUSION. Intravenous administration of doxorubicin to rats induced the development of toxic kidney damage with signs of NS. A characteristic indicator was the development of PU against the background of a decrease in GFR from day 5 and increased many times by the end of the observation period. The greatest contribution to the development of PU was made by an in-crease in albumin excretion. Morphological examination of the kidneys using electron microscopy made it possible to conclude with a high degree of probability that the developed pathology and FSGS are similar. At the same time, FRO activation was recorded, which was expressed in a sig-nificant pro-oxidant effect and a significant decrease in the antioxidant activity of the blood.
The role of stress reactions in the genesis of menstrual cycle disorders in recurrent urinary tract infections in minors
Authors: Chebotareva Yu. Yu. , Letifov G. M. , Petrov Yu. A. 
Published: June 2023

BACKGROUND. Extragenital diseases, including recurrent urinary tract infections, have an adverse effect on the reproductive health of children and adolescents. Vaginitis and menstrual cycle disorders, including primary oligomenorrhea, predominate in the structure of gynecological morbidity of minors suffering from recurrent UTIs.THE AIM: to study the role of stress reactions in the genesis of various variants of menstrual cycle disorders in minors suffering from recurrent UTIs to improve the dispensary management of this cohort of patients. PATIENTS AND METHODS. A prospective study was conducted in 98 adolescent girls aged 16 to 18 years. Taking into account the nature of the clinical course of UTI, all the subjects were divided into 3 groups: group 1 (n=41) – patients with UTI; group 2 (n=27) patients with frequent recurrence of UTI (more than 3 times a year (rIMP); group 3 (n=30) – minors, 1, 2 health groups with no IPM episode. A specialized gynecological examination, functional diagnostic tests, ultrasound examination of the placemark and ovaries, determination of cortisol, norepinephrine, adrenaline by enzyme immunoassay were carried out. Statistical analysis was performed using the program "SPSS Statistics 17.0 for Windows".RESULTS. Anovulation was observed in patients with frequent recurrence of UTI. Copious and prolonged menstruation, uterine bleeding and primary oligomenorrhea were observed only in patients with recurrent UTIs. In this cohort, inflammatory gynecological diseases take a chronic course. Polycystic ovarian syndrome (40.7 %) and chronic salpingoophoritis (44.4 %) were often detected in patients with frequently recurrent UTI. In patients suffering from UTI, in contrast to the data of the comparison group, there were significant violations of the nature of adaptive reactions, and changes in antistress reactions and their levels differed depending on the variant of the course of the microbial-inflammatory process. In patients with rare relapses of UTI, antistress reactions of a high level of reactivity prevailed, but there were reactions of calm and increased activation, training that took place at low levels of reactivity.CONCLUSION. Adaptive-compensatory disorders were revealed in almost every patient with recurrent UTI. Considering that stress is especially pathogenic during puberty, when hormonal and psychophysiological restructuring of the body occurs, prevention and complex therapy of microbial-inflammatory diseases of the urinary system in this category of patients should be carried out taking into account the formation of reproductive function and the severity of adaptation reactions.
Pengembangan Media Pembelajaran Interaktif Augmented Reality Mata Pelajaran Komputer Dan Jaringan Dasar
Authors: Widaraeni Fitri Sulis , Vivianti  
Published: June 2023

Kemajuan teknologi telah memberikan pengaruh besar dalam dunia pendidikan salah satunya yaitu pada media pembelajaran yang semakin bervariasi, salah satu teknologi yang dapat diakses melalui smartphone yaitu Augmented Reality (AR). Keterbatasan sumber belajar dapat membuat siswa mengalami kesulitan dalam belajar. Sehingga diperlukan sumber belajar dan media belajar yang dapat mendukung pembelajaran. Metode penelitian yang digunakan adalah penelitian dan pengembangan atau Research and Development (R&D) dengan model pengembangan ADDIE yaitu (Analisys, Design, Development, Implementation, Evaluation). Media pembelajaran ini telah layak dan efektif digunakan setelah dilakukan serangkaian pengujian. Pengujian oleh ahli media mendapat nilai rata-rata 83,92% atau dalam kategori sangat layak. Penilaian ahli materi mendapat nilai rata-rata 94,11% atau dalam kategori sangat layak. Penilaian siswa mendapat nilai rata-rata 91,92% atau dalam kategori sangat layak. Berdasarkan ketiga hasil uji kelayakan, maka media pembelajaran ini sangat layak digunakan sebagai alat bantu dalam pembelajaran. Sedangkan dari segi efektivitas media, mendapat nilai rata-rata N-Gain Score 75% atau dalam kategori cukup efektif. Sehingga media pembelajaran interaktif Augmented Reality cukup efektif digunakan sebagai alat bantu pembelajaran dalam meningkatkan hasil belajar siswa.