bluuebunny/crossref_metadata_2025_split huggingface dataset:
The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity
Authors: Wakasa Takeshi , Iimori Makoto , Nonaka Kentaro , Harada Akihito , Ohkawa Yasuyuki , Kikutake Chie , Suyama Mikita , Kobunai Takashi , Matsuoka Kazuaki , Tsunekuni Kenta , Kataoka Yuki , Ochiiwa Hiroaki , Miyadera Kazutaka , Sagara Takeshi , Oki Eiji , Ohdo Shigehiro , Maehara Yoshihiko , Kitao Hiroyuki 
Published: August 2023

ABSTRACTThe fluorinated thymidine analogue trifluridine (FTD) is a chemotherapeutic drug commonly used to treat cancer; however, the mechanism by which FTD induces cytotoxicity is not fully understood. In addition, the effect of gain-of-function (GOF) missense mutations of theTP53gene (encoding p53), which promote cancer progression and chemotherapeutic drug resistance, on the chemotherapeutic efficacy of FTD is unclear. Here, we revealed the mechanisms by which FTD induced aberrant mitosis and contributed to cytotoxicity in both p53-null and p53-GOF missense mutant cells. In p53-null mutant cells, FTD induced DNA double-stranded breaks, single-stranded DNA accumulation, and the associated DNA damage repair responses during G2 phase. Nevertheless, FTD-induced DNA damage and the related responses were not sufficient to trigger strict G2/M checkpoint arrest. Thus, these features were carried over into mitosis, resulting in chromosome breaks and bridges, and subsequent cytokinesis failure. Improper mitotic exit eventually led to cell apoptosis, caused by the accumulation of extensive DNA damage and the presence of micronuclei encapsulated in the disrupted nuclear envelope. Upon FTD treatment, the behavior of the p53-GOF-missense-mutant, isogenic cell lines, generated by CRISPR/Cas9 genome editing, was similar to that of p53-null mutant cells. Thus, our data suggest that FTD treatment overrode the effect on gene expression induced by p53-GOF mutants and exerted its anti-tumor activity in a manner that was independent of p53 function.
Cryptosporidiuminfection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus
Authors: Greigert Valentin , Saraav Iti , Son Juhee , Dayao Denise , Antia Avan , Tzipori Saul , Witola William H. , Stappenbeck Thaddeus S. , Ding Siyuan , Sibley L. David 
Published: August 2023

ABSTRACTCryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor settings. The majority of infections are caused by the human-specific pathogenC. hominisand absence of in vitro growth platforms has limited our understanding of host-pathogen interactions and development of effective treatments. To address this problem, we developed a stem cell-derived culture system forC. hominisusing human enterocytes differentiated under air-liquid interface (ALI) conditions. Human ALI cultures supported robust growth and complete development ofC. hominisin vitro including all life cycle stages.C. hominisinfection induced a strong interferon response from enterocytes, likely driven by an endogenous dsRNA virus in the parasite. Prior infection withCryptosporidiuminduced type III IFN secretion and consequently blunted infection with Rotavirus, including live attenuated vaccine strains. The development of hALI provides a platform for further studies on human-specific pathogens, including clinically important coinfections that may alter vaccine efficacy.
A systematic review of the literature on agri-food business models: critical review and research agenda
Authors: Miranda F. Javier , García-Gallego José Manuel , Chamorro-Mera Antonio , Valero-Amaro Víctor , Rubio Sergio 
Published: August 2023

PurposeThe aim of this study is to identify the way in which research on new business models in agri-food sector has been developed, in order to identify the main lines of work followed and determine a future research agenda in this field.Design/methodology/approachA systematic review of the literature is carried out, by applying the PRISMA method to identify and classify the main articles published on agri-food business models in journals included in the Web of Science Core Collection database.FindingsThe systematic literature review has identified three main forms of business models in the agri-food sector: sustainable business models, technology-based business models and cooperative business models. The three types of new business models are complementary and can sometimes be adopted together. The identification of these types of business models and the variants included in each of them is a valid starting point for new developments in this field.Research limitations/implicationsThe limitations of this study are those typical of any literature review and derived from the methodology used. The establishment of criteria relating to time, language, type of publication or database chosen means that this review may have left out relevant studies in this field of research. It is therefore recommended that new reviews be carried out with different criteria in the coming years in order to supplement the results obtained in this study.Originality/valueSome research gaps were identified that should be further explored in the future. First, the relationship between digitisation and technological innovation in agri-food business models and the level of implementation of sustainable objectives in these business models has not been researched thoroughly. In addition, and despite the fact that the crisis caused by the COVID-19 pandemic has boosted innovation in agri-food business models, the authors have detected a lack of papers focused on solving problems arising from the shortage of raw materials or labour, possible energy crises or external dependence on local markets when it comes to meeting demand. The war in Ukraine has demonstrated the limitations of international markets, mainly the European market, when it comes to dealing with problems arising from this type of crisis.
The antecedent cognitions of brand love and its impact on brand loyalty: the moderating role of sustainability marketing
Authors: Khalid Afia , Awan Raheel Amir , Ali Rizwan , Sarmad Imran 
Published: August 2023

Purpose
This study aims to examine the moderating effect of sustainability marketing on brand loyalty of brands that advertise their sustainable development agenda goals. The study highlights the mediating effect of brand love having cognitive antecedents of brand authenticity, popularity and congruence with private and social self of the consumer.

Design/methodology/approach
A mall intercept survey was used to collect data from consumers who use brands that embrace sustainable marketing strategies. Only those brands were selected which are popular as well as advertise sustainable practices in their brand communication (mainstream and social media). The data was self-administered by trained research assistants, who gathered data from a sample of 350 respondents.

Findings
The findings revealed that the popularity and authenticity of a brand play an essential role in developing brand love and later influences brand loyalty behavior. A larger effect is seen on brand love when there is congruence of private and social self with the brand. The brand has even a stronger relationship with brand loyalty when moderated by sustainability marketing.

Research limitations/implications
Brand love has the potential for long-term influences, only if sustainability marketing is used as a backbone. Brand managers should target an authenticity-seeking segment of consumers, who once convinced can lead to repeat business and brand loyalty and reduce dissonance. As sustainability marketing provides multiple benefits, genuine branding strategies should be devised that amalgamate into a single message spun around sustainability concerns and connecting the ethos of authenticity, popularity and self-expression. Future research may take into consideration more categories than this study on clothing, and consumer goods, adopting a mixed-methods approach. Moreover, a range of potential antecedents of brand love can be determined along with potential outcomes when aligned with external efforts such as sustainability, corporate social responsibility and international investment.

Originality/value
To the best of the authors’ knowledge, this is the first study investigating the moderating role of sustainability marketing on the relationship between brand love and brand loyalty and the mediating role of brand love between brand authenticity, popularity, social/private-self-expression and brand loyalty. It is also the first study documenting how sustainability marketing reinforces the brand loyalty for popular brands in developing countries like Pakistan. This study fills a research gap as it expands the existing literature on sustainability marketing and brand love that is generally focused on brand dimensions and not the brand communications and thus has not reached similar results.
A better start: board diversity matters in assessing stock price crash risk
Authors: Cho Kyungshick , Cho Jaeyoung , Bian Yiyang 
Published: August 2023

Purpose
The determinants that contribute to reducing stock price crash risk have garnered attention from scholars and practitioners. However, our understanding of the relationship between board diversity and stock crash risk, as well as the contextual factors that influence this relationship, remains limited. To address this gap, this study aims to investigate how different attributes of board diversity affect stock price crash risk, particularly under conditions of higher performance hazard and ownership concentration.

Design/methodology/approach
Using a two-stage least squares fixed-effects estimator, the authors analyze a panel data set of 1,792 firm-year observations across 282 firms listed on the KOSPI200 from 2010 to 2019.

Findings
Relation-oriented diversity reduces future stock price crash risk, particularly when firms experience performance shortfalls and have concentrated ownership structures, but task-oriented diversity has no significant effects. The results imply that only relation-oriented diversity strengthens governance mechanisms by curtailing managerial bad news withholding behaviors, and the role of relation-oriented diversity in reducing stock crash risk becomes more crucial when firms have higher performance hazard and concentrated ownership.

Originality/value
This study makes crucial contributions as follows: the authors contribute to the stock crash risk literature by shifting the focus from how to when board diversity matters in assessing stock crash risk; the authors extend the board diversity research and enhance scholarly understanding of the effects of board diversity on corporate governance by highlighting that not all aspects of board diversity improve firm governance mechanisms; and the authors widen the lens from a single attribute to multiple attributes of diversity to reveal the effects of diversity on boards in assessing future crash risk.
How to carry out organisational debriefing for team learning
Authors: Hebles Melany , Yániz-Alvarez-de-Eulate Concepción , Villardón-Gallego Lourdes 
Published: August 2023

PurposeThe debriefing is a procedure based on intra-team feedback, which has frequently been applied in university formation in health but has been less used in business. The aim of this research is to analyse best practices in the actual implementation of debriefing in organisations, based on criteria the guidelines for carrying out each stage established in the procedure.Design/methodology/approachTo achieve these goals, working teams from different organisations carried out 19 group-debriefing sessions on an authentic work problem. These sessions were observed and analysed following a qualitative approach.FindingsAfter observing a debriefing session in 19 organisations, four categories related to its implementation have been identified: Self-analysis, information, planning and orientation of the development of the team.Research limitations/implicationsIt is important to mention some limitations to this work. The major limitation was the lack of published literature related to the debriefing in the area of organisational management. The qualitative and exploratory nature of the study limits the generalisation of the results.Practical implicationsThe research has practical implications as the characterisation and description of each phase favours the transfer to implement the debriefing technique adequately in different types of organisations.Social implicationsIt has been observed that all forms of debriefing have a common purpose in learning and, team and employee development, due to the powerful transferability and usefulness of debriefing in different contexts. Therefore, knowing the correct use of debriefing is a breakthrough in this area. In addition, including this type of practice will not just facilitate a better performance, it will also help teams to learn to work in a team from their own experiences.Originality/valueIt has been characterised by the process of debriefing from the correct implementation of each phase through the analysis of the narratives that arise in the debriefing sessions carried out.
Distributed team cognition and collaborative problem-solving in project management
Authors: Fernandes Roberto Godoy , Silva Luciano Ferreira da , Vils Leonardo 
Published: August 2023

PurposeThe purpose of this paper is to verify how distributed cognition enhances collaborative problem-solving in the context of projects.Design/methodology/approachUsing qualitative research and in-depth interviews, a sample of 32 project managers with experience in traditional and agile methods acting in Brazil and internationally participated in the research process. The analysis process, utilising coding techniques, involved stages: open, axial, coding and selective coding. These stages encompassed the evaluation of categories based on a hierarchy, in order to determine an appropriate level of abstraction that properly explains theoretical findings.FindingsThe results indicate that distributed team cognition is significant for collaborative problem-solving. The data from the interviews allowed the proposal of a model of cognition, and the identification of the elements that support it.Practical implicationsUnderstand how aspects of distributed team cognition can impact the behaviours of the project professional and contribute to problem-solving in the project environment.Originality/valueThe elements observed affects the collaborative problem-solving by presenting a model of distributed cognition, which is composed by directed communication, collective interaction, trust building and collaborative behaviour.
The nexus between arms imports, military expenditures and economic growth of the top arms importers in the world: a pooled mean group approach
Authors: Chary Shreesh 
Published: August 2023

PurposeThis paper explores whether data back the claim that imports of armaments are inherently bad for economic growth. Regardless of one's point of view, the production and trade of weaponry is a significant industry with serious economic implications that warrant investigation. The financial repercussions of military spending have been extensively studied, but the economic effects of arms importation remain unknown.Design/methodology/approachThis study adopts a pooled mean group approach to investigate the nexus between arms imports, military expenditure and per capita GDP for a balanced panel of twenty-five of the top arms importers in the world from 2000 to 2021.FindingsThe authors find that arms imports and military spending negatively impact GDP per capita in the short run, but military spending is beneficial over the long run. The authors also used the Dumitrescu Hurlin Granger causality test, which revealed a unidirectional causation between per capita GDP and military expenditure, and a unidirectional causal relationship from military spending to arms imports.Research limitations/implicationsThis paper is deficient in a few aspects: first, it looks at only those countries comprising the top 70% of arms imports. Second, it omits many political, technological and legal factors that impact arms imports and military expenditures.Originality/valueThis paper looks into the impact of defense spending and arms imports on economic growth for twenty-five nations with the highest share of arms imports in recent times. It is a significant addition to the literature as it resolves the debate of whether or not the military expenditure is wasteful and whether arms imports significantly harm the nation's economic growth.
Network effects—do they matter for digital technologies diffusion?
Authors: Anacka Helena , Lechman Ewa 
Published: August 2023

PurposeThe main research target of this paper is to capture the network effects using the case of mobile cellular telephony, identified in European telecommunication markets, and its determinants enhancing the process of digital technologies diffusion.Design/methodology/approachThis research relies on panel and dynamic panel regression analysis. The empirical sample covers 30 European countries, and the period for the analysis is set for 2000–2019.FindingsThis work contributes by examining the network effects identified on European telecommunication markets that drive the process of digital technologies diffusion, but it also extends the understanding of the latter by tracing major determinants of fast network expansion, e.g. prices of access to and use of, per capita income, urbanisation, population density, accessibility of fixed telephony infrastructure. The main findings support the initial supposition that the installed base strongly enhances diffusion of new technologies, while other factors, for example, prices, are not of prime importance.Research limitations/implicationsThis research has certain managerial implications. The unveiled network effects driving adoption of technological innovations constitute a significant determinant of implementation of differentiation strategy by telecommunication companies. Due to network effects consumers' propensity to join the network is valued higher than the prices of services offered, which is crucial not only from the perspective of the company's pricing strategy but also enables telecommunication companies to introduce to the market new products and/or services concentrating on increasing its quality and usability rather than future prices.Originality/valueThis is the first work that empirically verifies the intercompanies and interpersonal diffusion of cellular telephony, hypothesising that this process relies on unique network effects.
Work more, pay more? The impact of customer participation on customer pay-what-you-want payments
Authors: Van Vaerenbergh Yves , Costers Annelies , Van den Broeck Anja 
Published: August 2023

PurposeThe optimal level of customer participation is an important factor in service design. However, researchers know little about the impact of customer participation for their willingness to pay and hence organizations’ financial outcomes. This paper examines the impact of customer participation in a pay-what-you-want (PWYW) pricing system, allowing customers to pay any price they want for a product or service.Design/methodology/approachThis paper reports the results of three experiments, in which the authors manipulated the level of customer participation (Study 1: Low versus high, Study 2: Medium versus high, Study 3: Low versus medium versus high) and measured customers' PWYW payments (Studies 1–3), customer satisfaction (Studies 1–3), perceived equity (Study 3) and perceived enjoyment (Study 3). Studies 1 and 3 were scenario-based experiments, while study 2 was a field experiment. Study 3 was preregistered.FindingsThe results support a direct effect of customer participation in service production on customer PWYW payments, yet only when comparing low to high levels of customer participation. High levels of customer participation lead to a decrease in perceived equity and an increase in perceived enjoyment, which in turn spilled over to customer PWYW payments through customer satisfaction.Originality/valueThis research provides causal evidence at the individual level of analysis for the relationship between customer participation in service production and financial results. The paper also provides insights into its underlying mechanisms.
Linking big data analytics capability and sustainable supply chain performance: mediating role of knowledge development
Authors: Fantazy Kamel , Tipu Syed Awais Ahmad 
Published: August 2023

Purpose
Drawing on the dynamic capability view, this study aims to examine the relationships between big data analytics capability (BDAC) and sustainable supply chain performance (SSCP) by exploring the mediating effects of knowledge development (KD) in terms of knowledge acquisition, information distribution, shared meaning and achieved memory.

Design/methodology/approach
Data were collected by questionnaire survey from 300 manufacturing organizations. Structural equation modeling was used to test the research hypotheses.

Findings
It was found that all the dimensions of KD were positively related to BDAC and SSCP. Although no direct association was established between BDAC and SSCP, the empirical findings indicated that all the dimensions of KD fully mediated the relationship between BDAC and SSCP. This highlights that organizations need to harness KD because developing BDAC alone may not be sufficient.

Originality/value
No previous research has explored how KD dimensions such as knowledge acquisition, information distribution, shared meaning and achieved memory mediate the relationship between BDAC and SSCP. This paper addresses this gap in the literature and contributes to the existing debate to better understand the conditions in which BDAC affects SSCP. Pointers for future research are also identified.