bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensity-dependent gamma electrical stimulation regulates microglial activation, reduces beta-amyloid load, and facilitates memory in a mouse model of Alzheimer’s disease
Authors: Liu Qian , Contreras Adam , Afaq Muhammad Shan , Yang Weijian , Hsu Daniel K , Russell Michael , Lyeth Bruce , Zanto Theodore P. , Zhao Min 
Published: December 2022

Abstract
Background: Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects.
Objective: The intensity-dependent effect of gamma electrical stimulation (GES) with a sinusoidal alternating current at 40 Hz on Aβ clearance and microglia modulation were assessed in 5xFAD mouse hippocampus and cortex, as well as the behavioral performance of the animals with the Morris Water Maze.
Methods and Results: One hour of epidural GES delivered over a month significantly 1) reduced Aβ42 load in the AD brain, 2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1+ cells, and 3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied.
Conclusion: The efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provides guidance for the development of this promising therapeutic approach.
A rare cause of mons pubis growing mass of a vulvar granular cells tumor – a Case Report
Authors: Domingues Sofia Jovina , Correia Lúcia , Sousa Vera , Mendes Ana , Rosa Filipa , Jorge Ana Francisca 
Published: December 2022

Abstract
Introduction: Granular cell tumor (GCT) is a rare clinical entity derived from Schwann cells of the outer sheath of the peripheral nerves, involving skin and subcutaneous tissue in most cases, but specifically GCT of the vulva is less frequent and labium majus is more prevalent site in vulva. The exact prevalence and pathogenesis of GCT haven’t been determined, but the risk of malignancy has been described at the rate of 2%. The authors report a case of 52-year-old postmenopausal woman, with a 2-year slow growth vulvar mass, without associated symptoms. On physical examination, a hard consistent and nodular subcutaneous mass, with 5 cm and located over the mons pubis was observed. Pelvic magnetic resonance identified a solid mass with irregular borders on subcutaneous tissue, upon mons pubis. An aspiration cytology was performed, suggesting a GCT leading a complete excision. Microscopically, GCT was compatible with a GCT without malignancy characteristics and the margins were negative.
Conclusion: This case reports a GCT on the mons pubis, whose rare location have only been reported in three cases. Despites its benign behavior, the unusual size conditioned a more aggressive surgical treatment and a multidisciplinary approach. During follow-up vulva and other anatomical locations should be carefully observed, because of its unusual local or extragenital recurrence.
Explaining Sexual Self-Care Status and its Predictor factors in Women Referring to Healthcare Centers of Sari, Iran, 2021
Authors: yazdani fereshteh , Simbar Masoumeh , HamzehGardeshi Zeinab , Zare Elham , Nasiri Malihe 
Published: December 2022

Abstract
Introduction: With the increase in the prevalence of non-communicable diseases and chronic health problems along with population growth, one of the definitions that is expanding is the ability to adapt and self-manage against diseases and self-care. Although there are several studies to examine self-care in medical conditions, there are not enough concepts and data related to sexual self-care. Therefore, the present study was conducted with the aim of explaining the status of sexual self-care and its predictor factors in women of reproductive age referring to healthcare centers.
Material and methods: This research was a cross-sectional study that was conducted on 400 women of reproductive age that referring to healthcare centers affiliated to Mazandaran University of Medical Sciences, Sari in 2021. Data were collected using personal-obstetric characteristics and sexual self-care questionnaires in women of reproductive age. Pearson correlation coefficients, independent t-test, one-way analysis of variance (ANOVA) and multiple linear regression model were used to analyze the data.
Results: The average total score of sexual self-care in reproductive age women participating in the research was 70.66% ± 12.52%. In addition, the ​​prevention of women's cancers and the prevention of unintended pregnancies obtained the lowest and highest scores, respectively. Factors such as age, education, education related to medical sciences, history of HIV testing, history of HPV vaccination, source of sexual information, method of contraception and infection-related action in a person can affect the level of sexual self-care in women. Based on the final regression model, education related to medical sciences (B = 5.46, P = 0.035), family income (B = 5.58, P = 0.025), prevention method (B = 10.127, P = 0.000) and action related to infection in the person (B = 12.27, P = 0.047) were the final predictors of sexual self-care score in reproductive age women.
Conclusion: Based on the findings of the study, development of self-care promotion programs for reproductive aged women are necessary in all areas of reproductive health, with a priority for women’s cancer prevention, and focusing on promoting education and related economic assistance. The results of this study can be available to experts and policy makers to design programs to promote sexual self-care in women.
Effects of Different Physiotherapy Modalities on Insomnia and Depression in Perimenopausal, Menopausal, and Post-menopausal Women: A Systematic Review
Authors: Lialy Hagar E. , Mohamed Malak A. , AbdAllatif Latifa A. , Khalid Maria , Elhelbawy Abdulrahman 
Published: December 2022

Abstract
Background

Menopause is the time that marks passing 12 months after last menstruation cycle in women between ages 40–50. Menopausal women have common symptoms such as: hot flashes, vaginal dryness, mood switching, depression and insomnia. The systematic review aims to determine the effects of different therapeutic and manual modalities on insomnia and depression in perimenopausal, menopausal, and post-menopausal women.

Methodology

After identifying our inclusion/exclusion criteria, adding our search term into 3 databases (PubMed, science open, and Cochrane), 3958 papers were identified. By using EndNote software, we excluded duplicates, unrelated, and non-full text papers. Thus, we included only 26 papers including 7 physiotherapy modalities: exercise, reflexology, footbath, walking, therapeutic and aromatherapy message, craniofacial message, and yoga.

Results

Most of the included modalities’ results showed a significant improvement in insomnia and depression symptoms in intervention group rather than control group.

Conclusion

Using non-pharmaceutical interventions such as physiotherapy have an overall positive impact on reducing insomnia and depression in menopause women.
Preparation, characterization and chromatographic evaluation of nickel oxide deposited silica stationary phase in hydrophilic interaction liquid chromatography
Authors: Guo Ying-Jie , Peng Xi-Tian , Yu Qiong-Wei , Feng Yu-Qi 
Published: December 2022

Abstract
Nickel oxide deposited silica stationary phase was prepared by liquid phase deposition and characterized. Its chromatographic performance was evaluated using several compounds such as typical polar compounds and benzimidazoles as probes. The effects of mobile phase variables such as acetonitrile content, salt concentration, and pH on the chromatographic behavior, thermodynamics, and kinetics of these compounds were investigated to reveal the retention mechanism. The results showed that the prepared stationary phase exhibited a retention behavior of hydrophilic interaction liquid chromatography, and that multiple retention mechanisms including partitioning, adsorption, ion-exchange, electrostatic attraction, and coordination interactions contributed to solute retention. The coordination of nickel oxide electron-accepting sites and the electron-donating solutes resulted in the mixed-mode retention on stationary phase, which could be very useful for enhancing the chromatographic selectivity for the analytes. The batch-to-batch reproducibility was acceptable with the relative standard deviations of probe retentionof less than 9.89%. The prepared nickel oxide deposited silica stationary phase was successfully employed for the separation of several compounds, and it showed better separation effect and different selectivity from silica column and commercial Zorbax NH2 column.
Outpatients prescribed with fluvoxamine around the time of COVID-19 diagnosis are not at a reduced risk of subsequent hospitalization and death compared to their non-prescribed peers: population- based matched cohort study
Authors: Trkulja Vladimir , Kodvanj Ivan 
Published: December 2022

Abstract
Purpose. To assess the effect of exposure to fluvoxamine around the COVID-19 diagnosis on subsequent hospitalizations and mortality in COVID-19 outpatients in a real-life setting.
Methods. Using nationwide administrative data, we identified adult COVID-19 outpatients diagnosed up to August 15, 2021 and conducted two cohort studies. Study 1 included subjects prescribed fluvoxamine around the index COVID-19 diagnosis (Cohort A), their peers suffering similar psychiatric difficulties but not prescribed fluvoxamine (Cohort B) and those free of psychiatric difficulties/treatments (Cohort C). Study 2 included subjects prescribed fluvoxamine (Cohort Fluvoxamine) and their peers prescribed paroxetine (Cohort Paroxetine). Cohorts were mutually exactly matched and incidence of COVID-19-related hospitalization, 30-day all-cause hospitalization and of COVID-19-related mortality was estimated.
Results. Of the 416030 first-episode outpatients, Study 1 included 1016 Cohort A, 95984 Cohort B and 275804 Cohort C patients. Matched Cohort A (n=749) vs. Cohort B (n=31336) relative risks (95%CI/CrI), frequentist and Bayes with skeptical, otpimistic and pesimistic priors, were: COVID-related hospitalization 1.37 (0.56-3.33), 1.15 (0.55-2.11), 1.03 (0.56.1.96) and 1.43 (0.63-2.94), respectively; 30-day all-cause hospitalization 1.88 (0.76-4.67), 1.76 (1.39-2.25), 1.76 (1.39-2.24) and 1.86 (1.43-2.38), respectively; COVID-19 related mortality 0.73 (0.35-1.55), 0.93 (0.53-1.76), 0.79 (0.40-1.54) and 0.88 (0.37-2.11), respectively. Matched Cohort A vs. C (866 vs. 222792) comparison yielded similar estimates, as did the matched Cohort Fluvoxamine vs. Paroxetine comparison in Study 2 (344 of 994 matched to 535 of 1796 patients).
Conslusion. Outpatients prescribed fluvoxamine around the time of COVID-19 diagnosis were not at a reduced risk of hospitalizations and mortality compared to their non-prescribed peers.
Evaluation of effective coverage for type 2 diabetes in Mexican primary care health information systems: a retrospective registry analysis
Authors: Gallardo-Rincón Héctor , Rios-Blancas Maria Jesus , Montoya Alejandra , Saucedo-Martínez Rodrigo , Morales-Juárez Linda , Mujica Ricardo , Cantoral-Preciado Alejandra , Idueta Lorena Suarez , Lozano Rafael , Tapia-Conyer Roberto 
Published: December 2022

Abstract
Background: As the leading cause of disability and the fourth leading cause of premature death in Mexico, type 2 diabetes (T2D) represents a serious public health concern. The incidence of diabetes has increased dramatically in recent years, and data from the Mexican National Health and Nutrition Survey (ENSANUT) indicate that many people remain undiagnosed. Persistent socioeconomic health care barriers exacerbate this situation, as T2D morbidity and mortality are worsened in vulnerable populations, such as those without social security. We evaluated the performance of public primary health centers (PHCs) in T2D medical attention through the measure of effective coverage (EC, a combined measure of health care need, use, and quality) at national, state, health jurisdiction, and municipality levels.
Methods: This retrospective analysis used blinded data recorded during 2017 in the Non-communicable Diseases National Information System (SIC) and T2D prevalence reported in 2018 ENSANUT to evaluate the EC achieved. We included individuals ≥20 years old without social security who did not declare the use of private health care services. Each EC component (need, use, and quality) was estimated based on the Shengelia adapted framework. The Kruskal–Wallis test was applied to evaluate the associations among EC quintiles and demographics.
Results: In 2017, 26.5 million individuals, aged ≥20 years, without social security, and without the use of private health care services, were under the care of 12,086 PHCs. The national prevalence of T2D was 10.3%, equivalent to 2.6 million people living with T2D in need of primary health care. Large contrasts were seen among EC components between and within Mexican states. We found that only 37.1% of the above individuals received health services at PHCs and of them, 25.8% improved their metabolic condition. The national EC was 9.3%, and the range (by health jurisdiction) was 0.2%–38.6%, representing a large geographic disparity in EC. We found an evident disconnect among need, utilization, and quality rates across the country.
Conclusions: Expansion and improvement of EC are urgently needed to address the growing number of people living with T2D in Mexico, particularly in states with vulnerable populations.
Cavernous sinus thrombosis linked to COVID-19 infection: a case report.
Authors: Geoffroy Bastien , grange Rémi , Boureille Pierre , Duvillard Cécile , Deloire Lucile , Boutet Claire , Grange Sylvain 
Published: December 2022

Abstract
Introduction:
The severity of SARS-CoV-2 virus infection is mainly related to its respiratory complications. However, it can also lead to numerous and varied thromboembolic events. Symptoms may include headache, fever, and neurological disorders. Since 2020, the clinical presentation of COVID-19 infection have become increasingly varied, leading in some cases to complex symptom associations, including numerous neurological symptoms. SARS-CoV-2 may lead to neurotropism which could reach the central nervous system and all cranial nerves. Cavernous sinus thrombosis is a rare condition, occurring as a complication of an ear, nose, and throat (ENT) or facial infection.
Case presentation:
A 73-year-old man without personal or family history of thrombosis, was referred to the emergency room for a sudden appearance of diplopia and ptosis, 3 days after testing positive for COVID-19 infection. An initial head CT-scan found no signs of stroke. He underwent a cerebral MRI 7 days later, which revealed a thrombosis of his right cavernous sinus. A brain CT scan follow-up 7 days later showed regression of the thrombosis with complete recanalization of the cavernous sinus. This was accompanied by a complete regression of diplopia and fever. He was discharged from the hospital 10 days after hospital admission.
Conclusions
In this case report, we describe a rare event of cavernous thrombophlebitis following a COVID-19 infection.
Atrial fibrillation incidence and outcomes in two cohorts of octogenarians: LiLACS NZ
Authors: Teh Ruth , Kerse Ngaire , Pillai Avinesh , Lumley Thomas , Rolleston Anna , Kyaw Tin Aung , Connolly Martin , Board Joanna , Monteiro Elaine , St-Clair Valerie Wright , Doughty Robert N 
Published: December 2022

Abstract
Background: Atrial fibrillation (AF), the most common cardiac arrhythmia in the general population, has significant healthcare burden. Little is known about AF in octogenarians.
Objective: To describe the prevalence and incidence rate of AF in New Zealand (NZ) octogenarians and the risk of stroke and mortality at 5-year follow-up.
Design: Longitudinal Cohort Study
Setting: Bay of Plenty and Lakes health regions of New Zealand
Subjects: Eight-hundred-seventy-seven (379 indigenous Māori, 498 non-Māori) were included in the analysis.
Methods: AF, stroke/TIA events and relevant co-variates were established annually using self-report and hospital records (and ECG for AF). Cox proportional-hazards regression models were used to determine the time dependent AF risk of stroke/TIA.
Results: AF was present in 21% at baseline (Māori 26%, non-Māori 18%), the prevalence doubled over 5-years (Māori 50%, non-Māori 33%). 5-year AF incidence was 82.6 /1000-person years and at all times AF incidence for Māori was twice that of non-Māori. Five-year stroke/TIA prevalence was 23% (22% in Māori and 24% non- Māori), higher in those with AF than without. AF was not independently associated with 5-year new stroke/TIA; baseline systolic blood pressure was. Mortality was higher for Māori, men, those with AF and CHF and statin use was protective.
In summary, AF is more prevalent in indigenous octogenarians and should have an increased focus in health care management. Further research could examine treatment in more detail to facilitate ethnic specific impact and risks and benefits of treating AF in octogenarians.
In House Generated SSR markers Reveals Genetic Variation and Population Structure in the Germplasm and Identification of Trait-Specific Markers that Enables Efficient Plant Breeding Program in Moringa (Moringa oleifera)
Authors: Paul Allen Eldho , M Williams , R Ajay Prasanth , Ranjani Veera , M Raveendran , Boopathi Manikanda 
Published: December 2022

Abstract
Moringa oleifera Lam. leaves are rich in nutritionally and therapeutically important bioactive compounds. As the knowledge on natural population genetic diversity is a prerequisite for further leaf biomass improvement, the morphological and molecular diversity were assessed among 55 South Indian ecotypes of M. oliefera. Leaf traits such as leaf length, breadth, fresh weight, dry weight and number of leaves were evaluated for morphological diversity and for genetic diversity, a total of 116 Simple Sequence Repeats (SSR; including 75 Genomic- and 41 Genic-SSR) were used. Polymorphic information content (PIC) for those SSRs had ranged from 0.0 (for SSR19876) to 0.96 for (SSR25987) with an average of 0.886. The heterozygosity ranged from 0.0 to 0.96 with an average of 0.215 and those allelic data clustered the investigated accessions into three main clusters using the Unweighted Pair Group Method with Arithmetic mean (UPGMA). Analysis of molecular variance (AMOVA) indicated that 71% of diversity was attributed to differences among individuals of population. Cluster analysis, Principal coordinate analysis (PCoA) and structure-based population study showed that, there was no geographical distribution among the genotypes. Marker-trait associations was also implemented with general and mixed linear models and 65 SSR markers were found to be associated with investigated leaf traits at p < 0.05. Among them, six SSRs were linked to the investigated leaf biomass traits with more than 70% influence on the expression of those traits and shown to have putative functions in leaf biomass, which would be potential candidates for molecular breeding in Moringa.
PVT1 Inhibition Stimulates Anti-tumor Immunity, Prevents Metastasis, and Depletes Cancer Stem Cells in Squamous Cell Carcinoma
Authors: Qin Zhen , Zhang Wenbo , Liu Shuo , Wang Yujia , Peng Xin , Jia Lingfei 
Published: December 2022

Abstract
Cancer stem cells (CSCs) cause tumor metastasis and immune evasion by asyetunknown molecular mechanisms. In the present study, we identify a long noncoding RNA (lncRNA), termed PVT1, which is highly expressed in CSCs and correlated closely with lymphoma node metastasis of head and neck squamous cell carcinoma (HNSCC). PVT1 inhibition eliminates CSCs, prevents metastasis, and stimulates anti-tumor immunity, while inhibiting HNSCC growth. Moreover, PVT1 inhibition promotes the infiltration of CD8+ T cells into the tumor microenvironment, thereby enhancing immunotherapy by PD1 blockade. Mechanistically, PVT1 inhibition stimulates the DNA damage response, which induces CD8+ T cellrecruiting chemokines, while reducing CSCs and metastasis via regulating the miR-375/YAP1 axis. In conclusion, targeting PVT1 might potentiate the elimination of CSCs via immune checkpoint blockade, prevent metastasis, and inhibit HNSCC growth.
Surgical treatment of rare pediatric cardiac myxomas:12 years clinical experience in a single institution
Authors: Zhao Shengliang , Li Hua , Wu Chun , Pan Zhengxia , Wang Gang , Dai Jiangtao 
Published: December 2022

Abstract
Background
Primary cardiac tumors are very rare, especially in children. Cardiac myxomas(CM) constitute the major proportion among these masses.Most of the reports in the literature are case reports.This study summarizes our 12-year clinical experience with surgical treatment of CM.
Methods
We retrospectively analyzed the clinical data of 23 children with CM(8 boys, 15 girls; median age: 8.92 months, range: 2 years 5 months-12 years 9 months; body weight: 11kg-45kg, median body weight: 28.21kg) admitted to our hospital in the previous 12 years, and we statistically analyzed their clinical manifestations and surgical methods.
Results
23 cases underwent myxoma excision under cardiopulmonary bypass(CPB), 16 cases directly underwent foramen ovale suture closure, 7 cases underwent pericardial patch repair due to large atrial septal defect, 3 cases underwent mitral valve repair, and 2 cases underwent tricuspid annulus contraction.The postoperative course was uneventful in most patients. A few patients had some complications.There were 8 cases of postoperative arrhythmia and 4 cases of postoperative low cardiac output syndrome.23 cases were followed up for 0.2 to 12.6 years, and 1 case with cerebral infarction combined with hemiplegia of the right limb recovered well after rehabilitation treatment.The 22 children had no cerebral embolism, acute heart failure, atrioventricular block and other related complications.There was no recurrence of CM in 22 cases, and all recovered after surgery.One patient recurred 5 years after the operation, and no tumour recurrence was observed after the second operation.One patient (4.35%) died due to myocardial infarction in early postoperative period with persistent low cardiac output.
Conclusions
Although CM in children is rare, it may cause cerebral infarction and other multi-organ embolism.Once CM is found, it must be surgically removed as soon as possible, which can not only reduce serious complications, but also has the possibility of curing.If the complete resection is possible, surgery provides better palliation and can possibly double survival.Follow-up echocardiographic should be paid attention to after surgery.