bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Role of Ca2+, Na+ on Swelling Behaviour of Natural Expansive Soils: A field Application Prespective
Authors: Re Peddireddy Sreekanth , Mohanty Bijayananda , Rao Bendadi Hanumantha , Reddy V. A. 
Published: January 2023

Abstract

Swelling behaviour is the prime hindrance for effective utilization of expansive soils as a geomaterial. To alleviate such behavior, stabilization with a suitable additive is essential. However, the current practice of additive and stabilization selection technique to treat the expansive soils predominantly relies on geotechnical properties, in particular on consistency limits. The present paper aims at demonstrating the role of chemical constituents on swelling properties in a comprehensive way. Elaborate tests to determine the swelling and chemical constituents are carried out and based on the obtained results, interrelations between them are developed. The analysis of results revealed the maximum swelling occurrence at NaTof 0.4–0.7%, CaTof 4-5.5%, total CEC of 45–70 meq/100g, and (Ca/Na)Tof 15.75 respectively. The results portray that swelling in clays is minimal when NaT<0.2%, CaT>5.5%, and total CEC < 20 meq/100g, delineating a fact that additive selection is highly effectual and economical for those soils that comprise constituents in these prescribed limits. The results provided in the study fetches two major benefits: first, likely avoidance of overdose usage of stabilizer content, and second, economization of the cost of stabilization by predicting the most appropriate additive. Such kind of in-depth studies is indeed imperative to decide the direct applicability or to choose an appropriate stabilizer to amend expansive soils such that the treated soil qualify as a geomaterial in the construction of earthen structures.
Access to Palliative Care in Patients with Advanced Cancer of the Uterine Cervix in the Low- and Middle-Income Countries: A Systematic Review
Authors: Ooko Francis , Mothiba Tebogo , Bogaert Peter Van , Wens Johan 
Published: January 2023

Abstract
Background
Women with advanced uterine cervical cancer suffer from a combination of moderate to severe physical, psychological, social, and spiritual distress due to their disease and are in need of palliative care to improve their quality of life. Approximately 85% of the women live in the low- and middle-income countries. Whether these women and their families access palliative care is not known.
Objectives
To understand the geographic accessibility, availability, financial accessibility, and acceptability of palliative care by patients with advanced cervical cancer and their families.
Methods
We conducted a Systematic review following PRISMA guidelines in CINAHL, Cochrane Central Register of Controlled Trials, MEDLINE, PsychINFO, PubMed and Scopus for the core concepts: palliative care, access, advanced uterine cervical cancer. Eligible articles were published in English, contained original data on experiences of patients and/or caregivers including symptoms management, and discussed available resources, communication, satisfaction, and healthcare utilization.
Results
Overall there was limited access to palliative care with insufficient facilities located in cities away from the rural areas where most women lived. Pervasive poverty was common with poor affordability of healthcare, travelling, accommodation, and subsistence expenses. Misconceptions and poor knowledge of the disease, cultural beliefs and attitudes, and other health system insufficiencies also presented challenges for access.
Conclusion
Concerted effort should be made to improve availability of palliative care facilities. Health education to address misconceptions and other cognitive barriers that limit access among cervical cancer patients and their families should be urgently undertaken in the LMICs.
Starch Quality Matrix (SQM): An Analytical Model for Predicting Resistant Starch (RS) in Rice (Oryza sativa.L)
Authors: Rahaman Sohel , Goswami Deepanyeta , Kumar Sanjeev , Bollinedi Haritha , Anand Anjali , Dash Sukanta , Rao Mahesh , Singh Archana , Singh Ashok Kumar , Krishnan Veda 
Published: January 2023

Abstract
Fine-tuning of starch digestibility to have a superior digestion-resistant fraction, i.e., resistant starch (RS), is of great interest in the agriculture, food, and nutrition domains, as it not only limits the glycemic amplitude but is also good for gut health. Traditionally, RS quantification has been done using human digestion simulation assays, which are technically demanding, time-intensive, and expensive. Considering the correlation of starch digestibility with the structural milieu, bestowed due to components, as well as other attributes, the present study aimed to develop a fundamental link among the reported explanatory variables affecting starch digestibility (microstructure, gelatinization temperature, total starch, amylose, amylopectin, and RS) in the form of a prediction model, the starch quality matrix (SQM). SQM was created using Pearson's correlation and Cramer's V statistics, and a regression model was created using the most significant variables (total starch and amylose) for RS prediction. The correlation between RS and inherent glycemic potential (IGP) was further validated using in-house developed in-vitro starch hydrolyzation kinetics. This study demonstrated for the first time a perspective relationship affecting starch digestibility and developed the SQM tool, which will aid in future trials to breed high-RS rice varieties with a low glycemic index.
Ameliorating the drought stress tolerance of a susceptible soybean cultivar, MAUS 2 through dual inoculation with selected rhizobia and AM fungus
Authors: Revanna Ashwin , Bagyaraj Davis Joseph , Basavaiah Mohan Raju 
Published: January 2023

Abstract
Drought stress is currently the major and primary abiotic stress factor for crop loss throughout the world. Although drought stress reduces the yield significantly, crop species differ in their stress response with some tolerate the stress effect while others not. Soybean is one such crop species reported to be more sensitive to drought stress during flowering, pod set and pod filling stage leading to a significant yield loss. In several systems, it has been shown that the soil microbes ameliorate the stress effect and therefore, yield loss is minimized under stress conditions. Realizing the importance of useful soil microbes, a field experiment was conducted to study the effect of selected microbial inoculants namely, N-fixing rhizobial bacteria, Bradyrhizobium liaoningense and P-supplying arbuscular mycorrhizal fungus, Ambispora leptoticha on the growth and performance of a drought susceptible soybean cultivar, MAUS 2 under drought condition. Moisture stress was imposed at flowering and pod filling stage by withholding the irrigation and the results revealed that, dual inoculation with rhizobia, B. liaoningense + AM fungus, A. leptoticha has improved the physiological, biometrie and yield besides the nutrient uptake and utilization abilities of a drought susceptible and high yielding soybean cultivar, MAUS 2 under water stressed conditions. Under water stressed conditions, inoculation of plants with microbial consortia has increased number of pods and pod weight per plant by 19% and 34% respectively; while, the number of seeds and seed weight per plant increased by 17% and 32% over un-inoculated control plants. Further, the growth and yield data revealed that, the inoculated plants under stress were on par with the un-inoculated irrigated control plants suggesting that the dual inoculation of plants with useful microbes would alleviate the stress effects and thereby making the plants to grow normally. The study therefore, infers that, rhizobia and AM fungal inoculation seems to be necessary when soybean is cultivated under drought or water limiting condition.
Individualized PEEP without recruitment maneuvers improves intraoperative oxygenation: A randomized controlled study
Authors: Pan Lili , Yang Li , Gao Lingling , Zhao Zhanqi , Zhang Jun 
Published: January 2023

Abstract
Background
Individualized positive end-expiratory pressure (PEEP) combined with recruitment maneuvers improves intraoperative oxygenation in individuals undergoing robot-assisted prostatectomy. However, whether electrical impedance tomography (EIT)-guided individualized PEEP without recruitment maneuvers could also improve intraoperative oxygenation is unknown.
Methods
Fifty-six male patients undergoing elective robotic assisted laparoscopic prostatectomy were randomly assigned to either individualized PEEP (Group PEEPIND, n = 28) or control with fixed PEEP of 5 cmH2O (Group PEEP5, n = 28). Individualized PEEP was guided by EIT after placing the patients in Trendelenburg position and intraperitoneal insufflation. Patients in Group PEEPIND maintained the individualized PEEP without intermittent recruitment maneuvers and those in Group PEEP5 maintained PEEP of 5 cmH2O intraoperatively. Both groups were extubated in a semi-sitting position once the extubation criteria was met. The primary outcome was the arterial oxygen partial pressure (PaO2) / inspiratory oxygen fraction (FiO2) prior to extubation. Other outcomes included intraoperative driving pressure, plateau pressure and dynamic respiratory system compliance, and the incidence of postoperative hypoxemia in post-operative care unit (PACU).
Results
The intraoperative median PEEPIND was 16 cmH2O (ranging from 12 to18 cmH2O). EIT-guided PEEPIND was associated with higher PaO2/FiO2 before extubation compared to PEEP5 (71.6 ± 10.7 vs. 56.8 ± 14.1, P = 0.003). The improved oxygenation extended into the PACU with lower incidence of postoperative hypoxemia (3.8% vs. 26.9%, P = 0.021). Additionally, PEEPIND was associated with lower driving pressures (12.0 ± 3.0 vs. 15.0 ± 4.4 cmH2O, P = 0.044) and better compliance (44.5 ± 12.8 vs. 33.6 ± 9.1 ml/cmH2O, P = 0.017).
Conclusion
Individualized PEEP guided by EIT without intraoperative recruitment maneuvers improved perioperative oxygenation in patients undergoing robot-assisted laparoscopic radical prostatectomy.
Trial registration:
China Clinical Trial Registration Center Identifier: ChiCTR2100053839. Registered 01/12/2021. First patient recruited on 15/12/2021. http://www.chictr.org.cn/showproj.aspx?proj=141373.
The safety and efficacy of immediate post placental IUD insertion versus the post puerperal IUD insertion in women undergoing cesarean delivery
Authors: Dawoud Mariam Ahmed Mohamed , Helal Omneya Mostafa , Komy Rasha Omar El , Sherbini Moutaz Mahmoud El , Awad Mirna Osama , Moussa Manal Abd Rabo 
Published: January 2023

Abstract
Objective
asses the safety and efficacy of immediate IUD insertion following delivery of the placenta in women undergoing cesarean delivery.
Study:
Randomized clinical trial that included 66 women, were divided equally in two arms, where each arm included 33 patients. The first group had IUD inserted 10 min after delivery of the placenta (post placental group) and the second group had their IUD inserted at 6weeks following delivery (interval group).
Results
The complication rate related to post placental IUD insertion was comparable to that of interval insertion. The expulsion and displacement rates were the same in both post placental and interval groups at 6 weeks and 3 months follow up.
Conclusion
Post placental IUD insertion is a safe and attractive option for postpartum contraception that should be offered to all women undergoing elective cesarean section after proper counseling.
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury
Authors: Zhong Wen-Jing , Zhang Jun , Duan Jia-Xi , Zhang Chen-Yu , Ma Sheng-Chao , Li Yu-Sheng , Yang Nan-Shi Yu , Yang Hui-Hui , Xiong Jian-Bing , Guan Cha-Xiang , Jiang Zhi-Xing , You Zhi-Jian , Zhou Yong 
Published: January 2023

Abstract
Background Necroptosis of macrophage plays an essential role in amplifying intrapulmonary inflammation during acute lung injury (ALI). However, the molecular mechanism that triggers macrophage necroptosis is still unclear. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor expressed broadly on monocytes/macrophages. The role of TREM-1 in macrophage fate during ALI needs further investigation.
Methods TREM-1 decoy receptor LR12 was used to evaluate whether the TREM-1 activation induced necroptosis of macrophages in lipopolysaccharide (LPS)-induced ALI in mice. Then we used an agonist anti-TREM-1 Ab (Mab1187) to activate TREM-1 in vitro. Mechanistically, macrophages were treated with RIPK3 inhibitor (GSK872), GTPase dynamin-related protein 1 (DRP1) inhibitor (Mdivi-1), or the nutrient-sensing mechanistic/mammalian target of rapamycin complex (mTOR) inhibitor (Rapamycin) to investigate macrophage necroptosis induced by TREM-1.
Results We first observed that blockade of TREM-1 attenuated macrophage necroptosis in LPS-induced ALI mice. In vitro, TREM-1 activation induced necroptosis of macrophages. mTOR has been previously linked to macrophage polarization and migration. Interestingly, we identified a previously unknown role of mTOR in regulating TREM-1-mediated mitochondrial fission, mitophagy, and necroptosis. Moreover, TREM-1 activation promoted DRP1Ser616 phosphorylation via mTOR signaling, leading to excessive mitochondrial fission-mediated necroptosis of macrophages, and finally exacerbated ALI.
Conclusion In this study, we reported TREM-1 acted as a necroptotic stimulus of macrophage, which fueled inflammation and aggravated ALI. We also provided compelling evidence suggesting mTOR-dependent mitochondrial fission as underpinnings of TREM-1-triggered necroptosis and inflammation. Therefore, regulation of necroptosis by targeting TREM-1 may provide a new therapeutic target for ALI in the future.
Perspectives toward e-learning system during Covid-19 pandemic among medical Colleagues, Egypt: A Cross-sectional survey
Authors: Abdelmonem Hanaa , Hamam Khaled M. , El-Helaly Abdullah Ahmed , Mostafa Marwa Gamal , Elsalam Eslam Mohamed Abd , Mohamed Mostafa Ramadan , Abdelsalam Asmaa E. , Awad Ahmed K. , Abd-ElGawad Mohamed , Ibrahim Mona Hamed , Collaboration IMedRA E.Learning 
Published: January 2023

Abstract
Background: WHO declared the outbreak of COVID-19, which affected the educational system stopping it in Egypt. To maintain the educational process, E-learning was a suggested solution. This study aimed to assess students' satisfaction regarding e-learning experience and effectiveness of this system on medical education in Egyptian universities.
Methods: A cross-sectional survey was conducted among medical schools in Egypt during 2020–2021. It was conducted through an online questionnaire composed of four sections: Demographic characteristics, quality of internet connection, the academic characteristics of the participants, and evaluation of the effectiveness of e-learning. We compared the effectiveness of e learning among the clinical and the academic students, and private and governmental universities.
Results: Among 90592 medical students in Egypt, 6393 students from 28 universities filled out the questionnaire with a 96.6% response rate. The age of participants ranged from 16 to 29 years old. Also, about 59.3% of them were females. The blended e-learning was the most applied by universities (43.1%), followed by partial type (33.4%), and full type (23.6%). About 73.7% of students had "always/often" constant internet connection. Forty percent of students were "dissatisfied/not satisfied at all", 38.3% showed "neutral" satisfaction, while 21.7% were "satisfied or highly satisfied". There was a significant difference regarding internet connection and availability favoring urban areas compared to rural areas (p<0.001). There was a significant difference favoring the academic education over the clinical education regarding the effectiveness of online learning (p<0.01) and private education over governmental regarding the effectiveness of online learning (p<0.001).
Conclusion: E-learning was better for academic education than for clinical education. It was better for private universities than governmental ones. Also, students in rural areas had worse availability and quality internet connection compared with those in urban areas.
Chandipura virus nucleoprotein interact with heat shock cognate 71 protein in Neuro-2a cells during replication
Authors: Kavathekar Vishal K , Sambhare Susmit , Anukumar Balakrishanan 
Published: January 2023

Abstract
To complete their lifecycle, viruses interacts with variety of cellular proteins. Identifying host proteins involved in the viral lifecycle is an excellent target for drug. In neuro-2a cells, we employed recombinant Chandipura virus (CHPV) nucleoprotein (N) as bait in a protein pull down assay to see which cellular proteins interact with nucleoprotein. A total of ten proteins interact with the CHPV N protein. Out of ten proteins, heat shock cognate 71 (HSC70) protein was investigated further. In CHPV-infected neuro-2a cells, confocal microscopy revealed that HSC70 co-localized with CHPV N protein, and that the expression was altered by viral infection. The association with HSC70 may help to mitigate the negative repercussions of misfolded proteins produced by viral polymerase's erroneous nature. More research on the role of these proteins in viral replication in infected cells is needed.
Long-Term Outcomes of Neoadjuvant Chemoradiotherapy with Total Mesorectal Excision in Locally Advanced Rectal Cancer: An Institutional Analysis.
Authors: Gorken ilknur Bilkay , Alicikus Zumre Arican , Aydin Barbaros , Akturk Nesrin , Kuru Ahmet , Canda Emre , Unlu Mehtat , Somali İsil , Oztop İlhan , Obuz Funda , Alanyali Hilmi , Sokmen Selman 
Published: January 2023

Abstract
Purpose: We aimed to determine the long-term oncologic outcome for patients with rectal cancer treated with preoperative Chemoradiotherapy (CRT) followed by total mesorectal excision (TME). In addition, we attempted to identify prognostic factors and the oncologic significance of a pathological complete response (pCR) on the patient's oncologic outcome.
Materials and Methods: Between February 1993 and January 2019, a prospectively maintained database of 357 consecutive patients with locally advanced (cT3-4 or any N1-2) primary rectal adenocarcinoma who received preoperative CRT followed by curative TME at our institute was analyzed.
Results: With a median follow-up of 72 (23–295) months, local recurrence occurred in 21 (5.9%) patients. The 5-, 10-, and 15-year locoregional free survival rates were 92.7%, 91.3%, and 91.3%, respectively. The median time to pelvic recurrence was 28 (12–103) months. Pathologic complete response was reported in 41 (11.6%) patients, and no patient with pCR developed local recurrence. Advanced pathologic T stage, pathologic nodal stage, and circumferential resection margin involvement were significantly poor prognostic factors for these patients.
Conclusion: Neoadjuvant radiochemotherapy for rectal cancer significantly improved the down-staging and sphincter preservation rates of low-lying rectal carcinomas. However, some patients will continue to recur after 5 years of follow-up.
Study of the antioxidant and bacterial activity of the flavonic glycosides existing in the plant "Cynodon Dactylon (L) Pers" by the free radical DPPH and the reduction of iron
Authors: KHEDIDJA BENZAHI , BRAHIM LABED , RABIA BENZAHI , ABDELKADER HASSANI , AMEUR ZORAI , ABDELAZIZ BOUHOREIRA , MABROUK SERRAOUI , BATOUL BEN ACHOURA SABRINA 
Published: January 2023

Abstract
The phytotherapy use of Cynodon Dactylon "L" Pers plant in traditional medicine has led us to work on the evaluation of the heteroside extracts of this plant, as well as aiding in the performance of phytochemical screening and the assessment of this plant's antioxidant activity using the "FRAP" method for reducing iron and scavenging DPPH radicals. Furthermore, research on the flavonoid components found in the two plant extracts' antibacterial properties is needed.
The antioxidant properties were demonstrated by identifying the effective inhibition concentration IC50 compared by the antioxidant effect of quercitin. The results mentioned that the extract of Ethyl Acetate has a higher activity than that of the Butanol extract "Ethyl Acetate extract IC50 ≃ 0.014 mg/ml, butanol extract IC50 ≃ 0.019 mg/ml". Also, the reducing power at the concentration of 2.5 mg/ml of ethyl acetate extract of Cynodon Dactylon was much higher (Ab=1.376 nm) compared to the Butanol extract (Ab= 1.297nm).
On the other hand, the butanol extract exerted weak activity against the referential bacterial strains. However, the ethyl acetate extract of flavonoids exhibited moderately positive activity on only two strains of "Enterococcus faecalis and Streptococcus pyogenes".
Modulation of mesenchymal stem cells protection against senescence during long-term expansion by the PI3K/Akt signaling
Authors: Luo Yi , Zhu Xinxin , Xiao Jian-Hui 
Published: January 2023

Abstract
Background and Objectives: Therapies using mesenchymal stem cells (MSCs) show immense potential and provide a promising new paradigm for treating previously untreatable diseases. These therapies require direct transplantation of a large number of MSCs obtained by long-term expansion in vitro, resulting in inevitable senescence and a decline in MSC quality, characterized by the appearance of senescence signatures, loss of proliferation, and decreased differentiation potential. However, the regulatory mechanism underlying MSC senescence remains unclear. We investigated this mechanism using young (passage 4 [P4]) and aging (P10) human amniotic MSCs (hAMSCs).
Methods and Results: P10 hAMSCs showed a senescence phenotype in vitro, including G1-phase cell cycle arrest and increased β-galactosidase-positive staining compared to P4 hAMSCs. Senescence is accompanied by the degeneration of stemness properties, including decreased expression of stemness transcription factors and decreased ability to differentiate into osteoblasts. Further analysis showed that aging hAMSCs contained lower levels of phosphorylated PI3K and AKT proteins, and thus lower activity levels, than those in young hAMSCs. To clarify whether low PI3K/Akt signaling promotes hAMSC senescence, we treated young hAMSCs with a specific inhibitor of phosphorylated AKT, MK2206. The treated cells showed a senescent phenotype at 72 h, accompanied by G1-phase cell cycle arrest and a decrease in proliferative and osteogenic capacities.
Conclusions: These data suggest that the PI3K/Akt signaling pathway protects against senescence during long-term in vitro expansion of hAMSCs and plays a central role in maintaining the hAMSC pluripotency.