bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the effects of highly aspherical lenslets versus defocus incorporated multiple segment spectacle lenses on myopia control
Authors: Guo Hui , Li Xianfang , Zhang Xiaoxiao , Wang Haizhao , Li Jianhua 
Published: February 2023

AbstractTo compare spectacle lenses with highly aspherical lenslets (HAL) versus defocus incorporated multiple segments (DIMS) on myopia progression control in 1 year. This retrospective cohort study involved data from children prescribed HAL or DIMS spectacle lenses in Guangzhou Aier Eye Hospital, China. To address the discrepancy that some children followed up at less than or more than 1 year, the standardized 1-year spherical equivalent refraction (SER) and axial length (AL) changes from baseline were calculated. The mean differences in the changes between the two groups were compared with linear multivariate regression models. Age, sex, baseline SER/AL, and treatment were included in the models. A total of 257 children who qualified for the inclusion criteria were included for the analyses (193 in the HAL group and 64 in the DIMS group). After controlling baseline variates, the adjusted mean (standard error, SE) of the standardized 1-year changes in SER for HAL and DIMS spectacle lens users were − 0.34 (0.04) D and − 0.63 (0.07) D, respectively. HAL spectacle lenses reduced myopia progression by 0.29 D (95% confidence interval [CI] 0.13 to 0.44 D) at 1 year compared to DIMS lenses. Accordingly, the adjusted mean (SE) ALs increased by 0.17 (0.02) and 0.28 (0.04) mm for children wearing HAL lenses and DIMS lenses, respectively. HAL users had 0.11 mm less AL elongation (95% CI − 0.20 to − 0.02 mm) than DIMS users. Age at baseline was significantly associated with AL elongation. Chinese children wearing spectacle lenses designed with HAL had less myopia progression and axial elongation than those wearing spectacle lenses designed with DIMS.
Clinical Diagnostic Values of C1q/TNF-Related Protein-3 for
Polycystic Ovary Syndrome Women with Insulin Resistance
Authors: Zhao Manyin , Li Yangyang , Zhang Yifan , Wang Xiaojie , Wang Xinshu 
Published: February 2023

AbstractPolycystic ovary syndrome (PCOS) is the most common disease caused by complex
endocrine and metabolic abnormalities in women. Insulin resistance is considered
an important pathophysiological factor in the pathogenesis of PCOS. Here we
investigated the clinical values of C1q/TNF-related protein-3 (CTRP3) as
predictive factor for insulin resistance. Our study included 200 patients with
PCOS, among which 108 had insulin resistance. Serum CTRP3 levels were measured
using enzyme-linked immunosorbent assay. Predictive values of CTRP3 for insulin
resistance was analyzed using receiver operating characteristic (ROC) analysis.
Correlations of CTRP3 to insulin levels, obesity measurements and blood lipid
levels were determined using Spearman’s correlation analysis. Our data
suggested that PCOS patients with insulin resistance had a higher obesity, lower
high-density lipoprotein cholesterol, higher total cholesterol, higher insulin
levels and lower CTRP3 levels. CTRP3 had a high sensitivity (72.22%) and
specificity (72.83%). CTRP3 significantly correlated to insulin levels,
body mass index, waist-to-hip ratio, high-density lipoprotein, and total
cholesterol levels. The predictive value of CTRP3 in PCOS patients with insulin
resistance was supported by our data. Our findings suggest that CTRP3 is
involved in the pathogenesis and insulin resistance of PCOS, which indicates its
value as an indicator for the PCOS diagnosis.
Challenges in Complex Oncological Chest Wall Reconstruction with Free Anterolateral Thigh Flap and Titanium Rib Plate
Authors: Chai Cheng Siew , Shamugam Kasthuri , Basiron Normala Binti , Zain Mohammad Ali Bin Mat , Zainal Hamidah Binti , Luen Koh Khai , Sathiamurthy Narasimman , Chai Diong Nguk , Pandian Benedict Dhamaraj A.L. Retna 
Published: February 2023

AbstractExtensive chest wall tumor resection and reconstruction possess a formidable challenge and require good collaboration between thoracic and reconstructive surgeons. In this article, we reviewed our experience in six consecutive cases requiring complex chest wall resection and reconstruction with titanium rib plates and free anterolateral thigh fasciocutaneous flap with fascia lata with a minimum 24 months follow-up postoperatively.Six patients with a mean age of 54 were diagnosed to have locally advanced malignant (n = 5) and benign (n = 1) tumors. They underwent wide local excision with a mean of six ribs resected, and the average size of the soft tissue defect was 389cm2. The integrity of the thoracic cage was restored by using titanium rib plates. Fascia lata was harvested along with free anterolateral thigh fasciocutaneous flap to achieve near airtight closure of pleural space for soft tissue coverage. Two patients required early flap exploration with successful flap salvage. One flap failure was reported on postoperative day 11 due to a mechanical cause and a redo surgery was required. With an average stay of 3 days in the intensive care unit, no perioperative pulmonary complications were recorded.Complex oncological chest wall resection and reconstruction with titanium rib plates and free anterolateral thigh fasciocutaneous flap with fascia lata yielded satisfactory aesthetic and physiological functional outcomes.
First Case Report of Breast Implant Associated-Anaplastic Large Cell Lymphoma from India: Are We Ready?
Authors: Khanna Soumya , Choudhary Sunil , Mantri Raghav , Arora Prateek , Arya Anupama , Bansal Richa , Grewal Preeti , Bhardawaj Nishu 
Published: February 2023

AbstractBreast implant associated-anaplastic large cell lymphoma (BIA-ALCL) has become a hot topic in recent plastic surgery and oncology forum. Its cases have been on the rise since its first emergence more than two decades ago. This condition is less known and management guidelines are still evolving. BIA-ALCL was seen recently with a classical presentation in one of our patients, who underwent immediate reconstruction with a macro-textured silicone implant following breast cancer surgery. We want to add the first case report from India to the global information database. There are still unanswered questions in its management, and we wish to highlight the same to make way for further research. With the rise in aesthetic and reconstructive implant surgeries, the knowledge of BIA-ALCL must expand among oncologists, radiologists, and pathologists for early identification and treatment for better patient outcomes.
‘Common nighthawk’ (Chordeiles minor) in Algonquian and Siouan languages
Authors: Collette Vincent 
Published: February 2023

AbstractSome North American indigenous languages have names for ‘common nighthawk’ (Chordeiles minor)’, ‘robin’, and ‘bird’ that are strikingly similar phonetically and have served to advocate long-distance genetic relationships among language families. While the Algonquian proto-form for ‘nighthawk’ has a rather straightforward pedigree, this is not the case for Siouan languages. Despite their phonetic resemblance, the ornithonyms for ‘nighthawk’ in half a dozen Siouan languages are unrelated; some are mimetic innovations and others are borrowed. This article analyses how and why ornithonyms are problematic in the application of the comparative method, a reality that affects the validity of long-distance claims, and offers alternative ways to deal with this issue. While ornithonyms can be inherited and undergo all the regular sound changes (or not) like other words, they are also problematic in many respects. First, they can be onomatopoetic and imitate the cry or call of the bird in question – a feature that accounts for their cross-linguistic similarity. Second, they can undergoad hocmimetic reshaping or become lexically contaminated based on phonetic similarity with other ornithonyms or words with which they are associated culturally. Third and last, they can be borrowed internally or externally. However, despite these comparative pitfalls (i.e., that some phonetically similar forms in a language family are not cognates), the analysis shows that our understanding of ornithological nomenclature can be enhanced by considering elements of ornithology, mythology, ethnographic knowledge, sayings, and puns pertaining to birds.
Diversity of yeasts in Indian fermented foods and alcoholic beverages
Authors: Tamang Jyoti Prakash , Lama Sonam 
Published: February 2023

Abstract
Ethnic Indian people have been domesticating beneficial microorganisms (bacteria, yeasts, and moulds) by their wisdom of ethno-microbiological knowledge for production of flavoured and socio-culturally preferred fermented foods and alcoholic beverages for more than 8000 years. The purpose of this review is to collate the available literatures of diversity of Saccharomyces and non-Saccharomyces species associated with Indian fermented foods and alcoholic beverages. A colossal diversity of enzyme- and alcohol-producing yeasts under the phylum Ascomycota has been reported from Indian fermented foods and alcoholic beverages. The distributions of yeast species show 13.5% of Saccharomyces cerevisiae and 86.5% of some non-Saccharomyces spp. in Indian fermented foods and alcoholic beverages, based on the reported literatures available till date. There is a research gap on prospect of yeasts research in India. Hence, we suggest that validation of traditional knowledge of domestication of functional yeasts needs to be studied to develop the functional genomics platforms for Saccharomyces and non-Saccharomyces spp. in Indian fermented foods and alcoholic beverages.
Genetic architecture of leaf morphology revealed by integrated trait module in Catalpa bungei
Authors: Zhang Miaomiao , Liu Bingyang , Fei Yue , Yang Xiaowei , Zhao Linjiao , Shi Chaozhong , Zhang Yueying , Lu Nan , Wu Chuangye , Ma Wenjun , Wang Junhui 
Published: February 2023

Abstract
Leaves are crucial for maintaining plant growth and development via photosynthesis, and their function is simultaneously regulated by a suite of phenotypic traits. Although much is known about the genetic architecture of individual leaf traits, unraveling the genetic basis of complex leaf morphology remains a challenge. Based on the functional correlation and coordination of multi-traits, we divided 15 leaf morphological traits into three modules, comprising size (area, length, width, and perimeter), shape (leaf lobes, aspect ratio, circularity, rectangularity, and the relevant ratios), and color (red, green, and blue) for an ornamental tree species, Catalpa bungei. A total of 189 significant single-nucleotide polymorphisms were identified in the leaves of C. bungei: 35, 82, and 76 in the size, shape, and color modules, respectively. Four quantitative trait loci were common between the size and shape modules, which were closely related according to phenotype correlation, genetic mapping, and mRNA analysis. The color module was independent of them. Synergistic changes in the aspect ratio, leaf lobe, and circularity suggest that these traits could be the core indicators of the leaf shape module. The LAS and SRK genes, associated with leaf lobe and circularity, were found to function in plant defense mechanisms and the growth of leaves. The associations between the SRK and CRK2 genes and the leaf lobe and circularity traits were further verified by RT–qPCR. Our findings demonstrate the importance of integrating multi-trait modules to characterize leaf morphology and facilitate a holistic understanding of the genetic architecture of intraspecific leaf morphology diversity.
Big Data, Machine Learning and Contraceptive Use: A Scoping Review
Authors: Finnegan Amy , Subburaj Saisahana , Hunter Kelly , Parkash Priya , Shulman Elizabeth , Ramkalawan Janel , Huchko Megan J 
Published: February 2023

Abstract
The use of big data sources, like Twitter, and big data analytical techniques, like machine learning, have increased in popularity in almost every area of scientific inquiry. However, recent reviews have not focused on contraceptive use to prevent pregnancy, which is surprising considering that over one-third of unmet need for contraception in low- and middle-income countries is made up of women who have discontinued a method. This manuscript details the results of a scoping review of peer-reviewed literature at the intersection of big data and contraceptive use to prevent pregnancy. We developed the Metrics of Reliability and Quality (MARQ) to provide guidance to assess studies using big data to understand contraceptive use and beyond. We found 31 articles that matched our inclusion criteria. The oldest article was published in 1971, and 61.3% (N = 19) of articles were published after 2016. Many articles using big data sources applied traditional analytical methods rather than big data methods. The overall quality of articles on the MARQ rubric was high; however, many articles employing big data sources did not discuss specific limitations, such as population representativeness or bias, and articles using big data methods seldom demonstrated whether big data methods outperform traditional analytical methods.
Essential role for albumin in preserving liver cells from TNFα‐induced mitochondrial injury
Authors: Duran‐Güell Marta , Garrabou Glòria , Flores‐Costa Roger , Casulleras Mireia , López‐Vicario Cristina , Zhang Ingrid W. , Cantó‐Santos Judith , Contreras Bryan J. , Sánchez‐Rodríguez María B. , Romero‐Grimaldo Berta , Horrillo Raquel , Costa Montserrat , Arroyo Vicente , Clària Joan 
Published: February 2023

AbstractCytokine‐induced inflammation and mitochondrial oxidative stress are key drivers of liver tissue injury. Here, we describe experiments modeling hepatic inflammatory conditions in which plasma leakage leads to large amounts of albumin to reach the interstitium and parenchymal surfaces to explore whether this protein plays a role in preserving hepatocyte mitochondria against the damaging actions of the cytotoxic cytokine tumor necrosis factor alpha (TNFα). Hepatocytes and precision‐cut liver slices were cultured in the absence or presence of albumin in the cell media and then exposed to mitochondrial injury with the cytokine TNFα. The homeostatic role of albumin was also investigated in a mouse model of TNFα‐mediated liver injury induced by lipopolysaccharide and D‐galactosamine (LPS/D‐gal). Mitochondrial ultrastructure, oxygen consumption, ATP and reactive oxygen species (ROS) generation, fatty acid β‐oxidation (FAO), and metabolic fluxes were assessed by transmission electron microscopy (TEM), high‐resolution respirometry, luminescence‐fluorimetric‐colorimetric assays and NADH/FADH2 production from various substrates, respectively. TEM analysis revealed that in the absence of albumin, hepatocytes were more susceptible to the damaging actions of TNFα and showed more round‐shaped mitochondria with less intact cristae than hepatocytes cultured with albumin. In the presence of albumin in the cell media, hepatocytes also showed reduced mitochondrial ROS generation and FAO. The mitochondria protective actions of albumin against TNFα damage were associated with the restoration of a breakpoint between isocitrate and α‐ketoglutarate in the tricarboxylic acid cycle and the upregulation of the antioxidant activating transcription factor 3 (ATF3). The involvement of ATF3 and its downstream targets was confirmed in vivo in mice with LPS/D‐gal‐induced liver injury, which showed increased hepatic glutathione levels, indicating a reduction in oxidative stress after albumin administration. These findings reveal that the albumin molecule is required for the effective protection of liver cells from mitochondrial oxidative stress induced by TNFα. These findings emphasize the importance of maintaining the albumin levels in the interstitial fluid within the normal range to protect the tissues against inflammatory injury in patients with recurrent hypoalbuminemia.
Histopathological Characteristics of Lacrimal Gland Prolapse
Authors: Huang Sonia , Juniat Valerie , James Craig , McNab Alan , Selva Dinesh 
Published: February 2023

Purpose:
Lacrimal gland prolapse is an acquired clinical condition that can present as an upper eyelid mass. Patients may undergo lacrimal gland biopsy when there is diagnostic uncertainty. We aim to describe the histopathological features of this patient group.

Methods:
Retrospective case series involving 11 patients.

Results:
The mean age at presentation was 52.3 ± 16.2 years (range: 31–77 years) with 8 patients (72.3%) being female. The most common presenting symptom was a palpable mass (9; 81.8%) followed by dermatochalasis (4; 36.4%). Three cases (27.3%) were bilateral. Common imaging findings include lacrimal gland enlargement and visualization of the prolapse. All biopsies demonstrated features of mild chronic inflammation with preserved glandular structures. Ten patients (90.9%) underwent surgical intervention involving lacrimal gland pexy and 1 patient (9.1%) was elected for observation only. One patient required repeat surgery after 4 years due to recurrence of symptoms. At the last follow-up, all patients had stable disease or complete resolution of symptoms.

Conclusion:
We present a case series of patients diagnosed with lacrimal gland prolapse who underwent a biopsy during their workup. All biopsies demonstrated features of mild chronic inflammation (dacryoadenitis). All patients had stable disease or complete resolution of symptoms. This case series suggests that chronic inflammation is a common finding in patients with lacrimal gland prolapse but bears minimal clinical consequence.
Idiopathic Intracranial Hypertension in Female-to-Male Transgender Patients on Exogenous Testosterone Therapy
Authors: Gutkind Naomi E. , Tse David T. , Johnson Thomas E. , Tse Brian C. 
Published: February 2023

Purpose:
To present four female-to-male (FTM) transgender patients on testosterone therapy diagnosed with idiopathic intracranial hypertension (IIH).

Methods:
The authors report 4 consecutive FTM transgender patients on exogenous testosterone diagnosed with IIH at a single institution.

Results:
Patient 1 presented with progressive blurred vision and a central scotoma 10 weeks after starting testosterone cypionate injections for hormonal gender transition. Bilateral grade 5 papilledema was present; the patient underwent bilateral optic nerve sheath fenestration with improved vision and resolution of edema. Patient 2 presented with transient vision loss, pulsatile tinnitus, and blurred vision 13 months after starting testosterone cypionate injections. The patient had grade 4 and 3 disc edema of the right and left eyes, respectively. Patient 3 presented with headaches and pulsatile tinnitus and was on testosterone injections at an unknown dose. The examination revealed grade 1 and 2 disc edema of the right and left eyes, respectively. Patient 4 presented with decreased vision, transient visual obscurations, and daily migraines while using topical testosterone gel every other day. Color vision was reduced, and lumbar puncture revealed elevated intracranial pressure. All patients had neuroimaging findings consistent with increased intracranial pressure.

Conclusions:
Testosterone therapy plays an essential role in FTM hormonal transitioning and may play a role in IIH. Patients undergoing testosterone therapy for gender transition should be informed of the possibility of developing IIH while on treatment, with obesity possibly increasing this risk. Comprehensive eye examinations should be considered in these patients before initiating hormone therapy.
Blood Concentrations of Volatile Organic Compounds Among US Workers From Various Trades
Authors: Zhang Kunqi , Lan Tuo , Bao Wei , Cui Qingbin , Thorne Peter S. 
Published: February 2023

Objective
This study aimed to examine blood benzene, toluene, ethylbenzene, o-xylene, and m-/p-xylene (BTEX) concentrations and their trends contrasting construction workers with workers in other occupations from 1999 to 2014 in the United States. Methods: Using data from the National Health and Nutrition Examination Survey, quantile regressions were performed to investigate associations between occupation and blood BTEX concentrations. Results: We found that high-risk and construction occupations were associated with increased blood concentrations of toluene, o-xylene, and m-/p-xylene at the 50–90th percentiles (P50–90), and ethylbenzene at P70–90. Moreover, although blood concentrations of ethylbenzene, o-xylene, and m-/p-xylene trended down among all US workers, no decreasing trend was observed for benzene and toluene among construction workers. Conclusions: Future studies are warranted to address questions about specific tasks to better assess VOC exposure from various trades.
Shared Leadership for Total Worker Health in the Construction Industry
Authors: Schwatka Natalie V. , Johnson Stefanie , Schilz Matthew 
Published: February 2023

Objective
The purpose of this study is to investigate the organizational, supervisor, team, and individual factors associated with employee and leader perceptions of shared Total Worker Health (TWH) transformational leadership in teams. Methods: We conducted a cross-sectional study with 14 teams across three construction companies. Results: Shared TWH transformational leadership in teams was associated with employees and leaders' perceptions of support from coworkers. Other factors were also associated it, but it differed by position. Conclusions: We found that leaders may be focused on the mechanics of sharing TWH transformational leadership responsibilities and workers may be more focused on their internal cognitive abilities and motivations. Our results suggest the potential ways of promoting shared TWH transformational leadership among construction teams.
How Work Pattern Transformation May Affect the Mental Health of Older Workers Faced With Unmet Health Care Needs During the Pandemic? A Comparative Investigation of Different Work Models
Authors: Yuan Bocong , Wang Muqing 
Published: February 2023

Purpose
This study compares the relation between unmet health care needs and mental health of older people with different work patterns.

Methods
This study uses data of Survey of Health, Aging and Retirement in Europe Corona survey (n = 51,632 to 51,731).

Results
The unmet health care need results in depression/sadness during the pandemic (0.304, P < 0.01). Besides, such problem is more salient in workers than the nonemployed population (0.066, P < 0.01 for workers; 0.058, P < 0.01 for the nonemployed) and more outstanding in those working on site and with hybrid work model compared with the telecommuters (0.264, P < 0.01 for telecommuters; 0.378, P < 0.01 for on-site workers; 0.437, P < 0.01 for hybrid work model).

Conclusions
Policymakers should focus on mental health of older people especially for those fully or partially involved in on-site work, when common health care need can be crowded out for limited health care resources during the pandemic.