bluuebunny/crossref_metadata_2025_split huggingface dataset:
High tumor copy number variations burden was associated with poor prognosis in patients with endocrine-resistant breast cancer
Authors: Lu Qianyi , Jiang Kuikui , Wang Na , Li Jiaping , Zhang Ping , Hong Ruoxi , Hong Xiaoyu , Shao Yang , Zhang Jingmin , Wang Shusen , Xu Fei 
Published: August 2023

Abstract
Background
Several studies have showed alterations in genes were associated with endocrine resistance in breast cancer. Nevertheless, genomic characteristics in primary endocrine-resistant breast cancer has not been thoroughly reported. Whether the genomic landscape of primary endocrine-resistant breast cancer is different from that of secondary endocrine-resistant breast cancer is unknown.
Methods
We analyzed the genomic landscape of primary tumor of consecutive patients with hormonal-receptor positive breast cancer that were genetically profiled by next generation sequencing using a 425 cancer-related genes panel in real-world clinical practice in our center between September, 2019 to December, 2020. According to the duration of endocrine treatment, we classified them into primary endocrine resistance group and secondary endocrine resistance group. Frequency of altered genes was compared between groups.
Results
A total of 41 tumor samples of which 25 cases in primary endocrine resistance and 16 cases in secondary endocrine resistance with same testing gene panel were included for analysis. TP53 (65.9%, 27/41), PIK3CA (46.3%, 19/41), MYC (36.6%, 15/41), MCL1 (31.7%, 13/41), CCND1 (31.7%, 13/41) were the most frequently altered genes in all 41 BCs. Copy number amplification of MYC was common in primary endocrine resistant group (48.0%), while with lower frequency in secondary endocrine resistant group (18.8%, P = 0.058). Copy number variation (CNV) of CCND1, MCL1, FGF19, ZNF217, ZNF703 and FGFR1 were commonly observed in primary endocrine resistance group. Percentage of CNVs in all variation types was significantly higher in primary endocrine resistance group than that in secondary resistance group (33.0% vs. 21.0%, P = 0.030). We further analyzed and found patients with more than 5 CNV events in the primary tumor, which we defined as high tumor CNVs burden, was associated with the poorer prognosis.
Conclusion
Copy number alterations were more commonly seen in primary endocrine-resistant breast cancer and high CNVs burden was associated with poor prognosis in patients with ER + breast cancer. This finding urged to further investigate the prognostic value of CNVs burden in patients with ER + breast cancer who receive endocrine therapy.
Wave interactions and fracture evolution in a thin glass plate under impact: a combined experimental and peridynamic analysis
Authors: Wang Yenan , Yen Chian-Fong , Yu Jian , Wright Jared , Bobaru Florin 
Published: August 2023

Abstract

We perform experiments and peridynamic simulations to understand the evolution of cracks in a thin glass plate, backed by a polycarbonate plate, impacted by a small projectile at 150m/s. We use the peridynamic model to investigate how various types of crack systems are generated by the impact event and how they evolve in time. Detail investigations of wave interactions and the different cracks and failure types they generate are performed using the peridynamic model. Post-mortem analysis of glass fragments allows comparisons with the computational results in terms of kind and location of crack systems. Fractography results provide information about the growth direction for some of the edge-cracks and the peridynamic results are used to explain the particular wave interactions leading to the observed behavior. The model captures, in an average sense, some wispy/very fine cracks (surface roughness) experimentally observed on fragments coming from the ends of the Hertzian-cone crack. This is the first attempt at using a computational model to predict the fine details and complex mechanisms of the origin and time-evolution of fracture and fragmentation in a glass plate from impact.
Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression
Authors: Hiebinger Felix , Kudulyte Aiste , Chi Huanting , de Lara Sebastian Burbano , Helm Barbara , Welsch Hendrik , Thi Viet Loan Dao , Klingmüller Ursula , Binder Marco 
Published: August 2023

Abstract
Type I interferons (IFNs) play a central role not only in innate immunity against viral infection, but also in the antitumour response. Apart from indirect immune-modulatory and anti-angiogenic effects, they have direct impact on cell proliferation. Particularly for cancer arising in the context of chronic inflammation, constant exposure to IFNs may constitute a strong selective pressure during tumour evolution. Expansion of neoplastic subclones or -populations that developed resistance to the antiproliferative effects of IFNs might constitute an important contribution to immunoediting of the cancer cells leading to more aggressive and metastasising disease. Experimental evidence for this development of IFN-insensitivity has been scarce and its molecular mechanism is unclear. In this study we demonstrate that prolonged (six weeks) exposure of cells to IFN-β in vitro reduces their sensitivity to its antiproliferative effects, and that this phenotype was stable for up to four weeks. Furthermore, we observed substantial differences in cellular sensitivity to growth inhibition by IFN-β in a panel of ten different liver cancer cell lines of varying malignity. IFN-resistance was most prominent in a pair of highly dedifferentiated cell lines, and least in cells from well-differentiated tumours, fostering the hypothesis of IFN-driven immunoediting in advanced cancers. In both settings, long-term IFN selection in vitro as well as in dedifferentiated tumour cell lines, we found IFNAR expression to be substantially reduced, suggesting the receptor complex, in particular IFNAR2, to be a sensitive target amenable to immunoediting. Beyond new insights into possible molecular processes in tumour evolution, these findings might prove valuable for the development of biomarkers allowing to stratify tumours for their sensitivity to IFN treatment in the context of patient tailored therapies.
Managing Risks and Crises in the Logistics Sector: A Comprehensive Analysis of Strategies and Prioritization Using AHP Method
Authors: Mızrak Filiz 
Published: August 2023

Abstract
In the fast-paced and intricate landscape of the logistics sector, the emergence of risks and crises presents a critical need for effective management strategies. This research undertakes an analysis of risk and crisis management practices within the logistics industry filling the gap in the literature and aims to identify viable strategies and prioritize them using the Analytic Hierarchy Process (AHP) method. Through literature review and insights gathered from interviews with five industry experts, this study unveils the challenges faced by logistics companies and unveils existing risk and crisis management approaches. Employing the AHP method, the research provides a systematic framework for prioritizing these strategies based on their significance and potential impact. The findings contribute to the development of a strategic risk and crisis management toolkit, empowering logistics firms to proactively address challenges, ensure adaptability, and bolster resilience amidst a dynamic business environment. The insights provided by this study will prove invaluable to logistics professionals, scholars, and policymakers, enabling them to take actionable measures that enhance operational efficiency and ensure long-term sustainability within the logistics sector.
EFR-IC: Ensemble Fuzzy association Rule-based classifier for Imbalanced data streams with Concept drift
Authors: Roshanfekr Saeideh , Razzazi Mohammad Reza 
Published: August 2023

Abstract
One of the most contestable problems in online learning is concept drift. In addition, if the data stream has imbalanced data, the detection of concept drift is more difficult, especially, when drift is in minority samples. Ensemble classifiers are also effective for the data stream classification with concept drift. By adjusting the weight to every individual classifier, we can manage the concept drift and misclassification problems. Using association rule mining techniques can help in balancing datasets and detecting concept drift in the early levels. In this article, we propose an Ensemble Fuzzy association Rule-based Classifier for Imbalanced data with Concept drift (EFR-IC) to deal with imbalanced streaming data containing concept drift. EFR-IC has five advantages compared with the existing methods as follows: 1) it does not need the data from previous chunks so in terms of storage space is more economical than similar methods; 2) it is stable in stationary and nonstationary environments; 3) due to the synchronization of all steps of algorithm execution -handling imbalanced data, concept drift detection, classification- execution speed is much better than similar methods; 4) it can be adapted to the new condition when swapping majority class to minority class; 5) it can timely react to multiple kinds of concept drifts. Experiments on both real and synthetic datasets containing concept drift show the effectiveness of EFR-IC in learning nonstationary imbalanced data sets.
Comparison of endoscopic versus CT assessment of stone-free status after percutaneous nephrolithotomy (PCNL)
Authors: Hartung Friedrich Otto , Müller Kim Julia , Herrmann Jonas , Gruene Britta , Michel Maurice Stephan , Rassweiler-Seyfried Marie-Claire 
Published: August 2023

Abstract
Purpose
This study is aimed to determine whether postoperative low dose computed tomography (LDCT) imaging is necessary after percutaneous nephrolithotomy (PCNL), or the surgeon's intraoperative assessment of residual fragments (RF) is sufficient and avoidance of postoperative imaging with reduction of radiation exposure can be achieved.
Methods
Data of all 610 patients who underwent PCNL in prone position in our institution from February 2009 to September 2020 was collected. Parameters such as age, gender, BMI, ASA-Classification, stone related parameters and the surgeon’s assessment of stone-free status were analyzed. The LDCT performed postoperatively was compared to the intraoperative assessment of the surgeon regarding RF.
Results
The mean age of patients was 52.82 years; the mean BMI was 28.18 kg/m2. In 418 cases, the surgeon made a clear statement about the presence of RF and postoperative LDCT was carried out. The discrepancy between the two methods (surgeon´s assessment vs. LDCT) was significant at p < 0.0001. The sensitivity, specificity, positive and negative predictive value of the surgeon when assessing RF were 24.05%, 99.45%, 98.28% and 50%. Stone free rate (SFR) after primary PCNL was 45.57%. The overall SFR at discharge was 96.23%.
Conclusion
Although the surgeon´s assessment of RF was reliable, postoperative LDCT imaging should still be performed if endoscopic stone clearance is suspected due to the high false negative rate and the low negative predictive value. The optimal timing of postoperative imaging following PCNL remains unclear.
Residents Underestimate Their Robotic Performance: Evaluating Resident Robotic Console Participation Time
Authors: Yoder Lauren , Elson Nora , Meister Katherine , Guend Hamza 
Published: August 2023

Abstract

Objective
Lack of formal national robotic curriculum results in a void of knowledge regarding appropriate progression of autonomy in robotic general surgery training. One midwestern academic surgical training program has demonstrated that residents expect to independently operate more on the robotic console than they perceive themselves to do. As such, our study sought to evaluate expectations of residents and faculty regarding resident participation versus actual console participation time (CPT) at a community general surgery training program.
Design
We surveyed residents and faculty in two phases. Initially, participants were asked to reflect on their perceptions and expectations from the previous six months. The second phase included surveys (collected over six months) after individual cases with subjective estimation of participation versus CPT calculated by the Intuitive Surgical, Inc. MyIntuitive application. Using Mann-Whitney U-Test, we compared resident perceptions of CPT to actual CPT by case complexity and post-graduate year (PGY).
Results
Faculty (n = 7) estimated they allowed residents to complete a median of 26–50% of simple and 0–25% of complex cases in the six months prior to the study. They expected senior residents (PGY-4 and PGY-5) to complete more: 51–75% of simple and 26–50% of complex cases. Residents (n = 13), PGY-2 through PGY-5, estimated they completed less than faculty perceived (0–25% of simple and 0–25% of complex cases). Sixty-six post-case (after partial colectomy, abdominoperoneal resection, low anterior resection, cholecystectomy, inguinal/ventral hernia repair, and others) surveys were completed. Residents estimated after any case that they had completed 26–50% of the case. However, once examining their MyIntuitive report, they actually completed 51–75% of the case (median).
Conclusions
Residents, especially PGY-4 and 5, completed a higher percentage than estimated of robotic cases. Our study confirms that residents can and should complete more of (and increasingly complex) robotic cases throughout training, like the transition of autonomy in open and laparoscopic surgery.
Comparison of temperature and renal tissue thermal damage by Holmium laser with different energy parameters during lithotripsy: in vitro porcine kidney model
Authors: Wei Wei , Chen Ming , Xie Le , Mai Yuan , Zhu Huacai , Xu Zhanping 
Published: August 2023

Abstract

OBJECTIVE
The holmium laser percutaneous nephrolithotripsy was simulated by porcine kidney calculus model in vitro to investigate the thermal damage of renal tissue by holmium laser with different energy parameters.
METHODS
We placed human kidney calculus specimen in a fresh vitro porcine kidney, then insert thermocouple temperature probes into the submucosa of the renal pelvis and rewarmed in a 37°C water bath. The renal parenchyma was penetrated with a percutaneous nephrological sheath through moderate irrigation rate of 30 ml/s in 18℃, and the Holmium laser was used to fragment the stone under the nephroscope and record the temperature.
RESULTS
The four independent models were lithotripsy with 30W and 60W laser for 5 and 10 minutes, respectively; the mean temperature of 30W vs. 60W within 5 minutes was 36.06°C vs. 39.21°C (t = 5.36, P = 0.00) and the highest temperature was 43.60°C vs. 46.60°C; the mean temperature of 30W vs. 60W within 10 minutes was 37.91°C vs. 40.13 ℃ (t = 5.28, P = 0.00), maximum temperature 46.80℃ vs. 49.20℃. Pathologically, each kidney was observed to have different degrees of thermal injury lesions, and the higher the power and longer the time the more severe the injury, but the injury was mainly limited to the uroepithelial and subepithelial tissues, with rare damage to the renal tubules, etc.
Conclusion
The higher power and longer time of holmium laser excitation will raise the intrarenal temperature significantly and cause a certain degree of thermal damage to the kidney tissue, but overall it is safe and reliable, and urologists can avoid more side damage through surgical experience skills.
Robotic pyeloplasty learning curve for a pediatric surgeon without previous laparoscopic pyeloplasty experience
Authors: Planchamp Thibault , Bento Lucas , Mouttalib Sofia , Belbahri Ichrak , Coustets Bernard , Aissa Dalinda Ait , Abbo Olivier 
Published: August 2023

Abstract
INTRODUCTION: Robotic pyeloplasty has become a technique of choice for pyelo-ureteral junction syndrome treatment in children. Less invasive than open surgery, robotic pyeloplasty also has a lower learning curve than laparoscopic pyeloplasty. This is how a new generation of surgeons without previous laparoscopic pyeloplasty experience has begun training in robotics.
PURPOSE: To assess the robotic-assisted pyeloplasty learning curve for a pediatric surgeon only trained in open pyeloplasty, and to investigate if that mode of practice is safe and effective.
METHODS: Data was collected from all children operated on for pyelo-ureteral junction syndrome by the same surgeon in our center between 2015 and 2021. Cases were divided into 4 groups of 14 consecutive procedures to analyze the learning curve.
RESULTS: 56 patients were operated on, with a median (IQR) age, weight and hospital stay of 9 years and 1 month old (3.5), 29 kg (17.3), and 3 days (2) respectively. The mean ± SD operative times were 146.5 ± 39.3, 123.2 ± 48.1, 103.1 ± 29.5, and 141.7 ± 25.0 minutes, with a unique significant difference between groups 1 and 3 (p=0.007**). Only two intraoperative and nine postoperative complications were observed. The surgery was successful in 98% cases.
CONCLUSION: Our study shows that a significant improvement in surgical time could be achieved in the first 30 cases, safely and efficiently even without previous laparoscopic pyeloplasty experience.
Modelling &amp; Analysis of Interfacial Crack of Bimaterial Plate by NURBS Aided Extended Finite Element Method
Authors: Sinha Gourav Prasad , Kumar Bipin 
Published: August 2023

Abstract
The stress intensity factor (SIF) of bimaterial is computed by implying XIGA (Extended IsoGeometric Approach) is discussed in research work. The cracks in the plates are varied in their angular orientation to recognize the influence of variation on the slope of cracks. The NURBS-based isogeometric approach simulates the problem of crack & interface under the partition of unity method. The jump at the interface between two materials is represented by the level set function whereas the strong interval at a fracture i.e. crack is represented by asymptotic enrichment & Heaviside function. The method of interaction integral is applied to evaluate the SIF which is validated by results obtained by Pathak [60].
The investigation on properties of Ti- 5Si and Ti- 5Nb implant alloys coated by bioactive based composite coating
Authors: Jabbar Shahad Abduladheem , Abdulkader Niveen Jamal , Ahmed Payman Sahbah 
Published: August 2023

Abstract
Ti alloys are extensively used in orthopaedic applications due to their good mechanical and biocompatibility properties. It is required to improve their overall properties, corrosion resistance, and ion release. To mix Si and Nb alloying components with CP-Ti, powder metallurgy was used. Multiple torch fires were used to coat Ti- 5Nb and Ti- 5Si alloys with two distinct types of Nanocoatings HAP+25%SiC (type-A), and Zeolite+25%ZrO2 (type-B). The Nb and Si were introduced as alloying elements of 5%Wt. in two samples. Different characterisation techniques, including (FESEM) and (EDS), XRD, AFM, Hardness, Ultimate tensile strength, corrosion resistance, and AAS, are used. Coatings (types A and B) improved the hardness and ultimate strength of Ti alloys, particularly Ti- 5Si coated by HAP+25%SiC, according to the findings. Because a permanent oxide layer (TiO2 and SiO2) is generated when Ti alloys, particularly Ti- 5Si, are coated with Zeolite ZSM5+25%ZrO2, they corrode at a lesser rate than other samples. Ti- 5Nb has a significant ion release, whereas Ti-5Si coated zeolite+25%ZrO2 has a comparatively modest Ti ion release.
Unpacking Galvanic Vestibular Stimulation using simulations and relating current flow to reported motions: Comparison across common and specialized electrode placements
Authors: Truong Dennis Q. , Thomas Chris , Ira Sanjidah , Valter Yishai , Clark Torin , Datta Abhishek 
Published: August 2023

Abstract
Galvanic Vestibular Stimulation is a non-invasive electrical stimulation technique that is typically used to probe the vestibular system. While commonly delivered using two electrodes, additional electrode placements have been employed. Our objective was to systematically evaluate all known placements, compare induced current flow, and how it relates to the archetypal virtual and sway motions. The ultimate goal is to help users in having a better understanding of the effects of different configurations. We simulated seven placements using an ultra-high-resolution model. Induced electric field (EF) patterns at the cortical and the location of vestibular organs were determined. As expected, current flow patterns are electrode placement specific. Placements with two electrodes generally result in higher EF magnitude. Placements with four electrodes result in lower percentage of current entering the cranial cavity. Symmetric placements do not result in similar EF values in the left and the right organs highlighting inherent anatomical asymmetry. Asymmetric placements may result in as much as ~ 3-fold higher EF in one organ over the other. The percentage of current entering the cranial cavity varies between ~ 15–40% depending on the placement. Detailed analysis such as this may be used to help understand mechanism of action, guide stimulation strategy, ultimately resulting in quantitatively informed rational / optimal choices.
Experimental study on the hydraulic performance of the horizontal main drain of building drainage systems with solid waste
Authors: Xu Ping , Fu Bin , Song Yilin 
Published: August 2023

Abstract

Water–air two-phase flow has been the theoretical basis of traditional building drainage systems. However, with the popularization of water saving devices, more research investigations need to be performed on the impact of solid waste on drainage systems. Through experiments under the solid waste scenario, the effects of drainage volume, diameter, and slope of the pipeline on the hydraulic performances of the horizontal main drain were investigated. The results showed that the drainage volume, diameter, and slope of the pipeline did not affect the location of the hydraulic jump on the horizontal main drain. The heights of the hydraulic jump were proportional to the discharge volumes and diameters of the pipeline, but inversely proportional to the slopes of the pipeline. The depth ratio was mainly responsible for the change of positive pressure value in the horizontal main drain. The depth ratios were proportional to the drainage volumes and inversely proportional to the diameters and slopes of the pipeline. The final deposition distances of solid wastes in the horizontal main drain were proportional to the discharge volumes and the pipeline slopes. The self-cleaning lengths of the clear water were 1.2∼1.6 times of the real final deposition distances of solid wastes.
Effect of Kangen and reverse osmosis water on dental plaque, salivary pH and salivary Streptococcus mutans counts: a randomized-controlled trial (A preliminary study)
Authors: Kusumakar Ananta , Akram Zainab , Khairnar Mahesh Ravindra , Jadhav Sachin Kumar , Sabharwal Harloveen , Priyadarsini S Savitha , PG Naveen Kumar 
Published: August 2023

Abstract
Purpose: The present randomized-controlled trial was conducted to assess the effect of Kangen water and reverse osmosis (RO) water on dental plaque, salivary pH and salivary Streptococcus mutans count. Materials and methods: This randomized control trial was conducted for 14 days on 24 randomly selected participants from the pool of undergraduate dental students. Participants were randomly divided into two groups of 12 each: the Kangen water (pH 9) group and the RO water group. Participants in each group were asked to drink allocated water for 7 days. Dental plaque, salivary pH and microbial colony-forming units (CFUs) were assessed after 7 and 14 days. Results: Intragroup comparison showed that all three outcomes showed a significant improvement in the Kangen water group after 14 days, whereas no difference was seen in the RO water group. Intergroup comparison showed a significant difference in plaque score and CFU among the two groups after 7 and 14 days, whereas pH between the two groups did not show a significant difference. Conclusions: Regular drinking of alkaline Kangen water with pH 9 was found to be effective in reducing plaque and salivary Streptococcus mutans count when compared to RO water.