bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bidirectional Associations of Awareness of Age-Related Change and Attitudes Toward Own Aging With Social Media Use
Authors: Sabatini Serena , Wilton-Harding Bethany , Ballard Clive , Brooker Helen , Corbett Anne , Hampshire Adam , Windsor Tim D 
Published: May 2023

Abstract

Objectives
We test whether higher awareness of age-related gains (AARC-gains), lower awareness of age-related losses (AARC-losses), and more positive attitudes toward own aging (ATOA) are cross-sectionally related to more frequent social media use. We also investigate the strength and direction of the associations of AARC-gains, AARC-losses, and ATOA with social media use over 1 year, from before to after the onset of the coronavirus 2019 pandemic.

Methods
We used cross-sectional data from 8,320 individuals (mean age = 65.95 years; standard deviation = 7.01) and longitudinal data from a subsample of 4,454 individuals participating in the UK PROTECT study in 2019 and 2020. We used ordered regression models, linear regression models, and tests of interaction. Models were adjusted for age, sex, education, and employment.

Results
Higher AARC-gains and more positive ATOA, but not AARC-losses, were cross-sectionally associated with more frequent social media use. Social media use became more frequent at follow-up. In the longitudinal models controlling for baseline levels of the outcome variable, more frequent baseline social media use predicted increases in AARC-gains, whereas baseline AARC-gains did not significantly predict the frequency of social media use at follow-up. Baseline frequency of social media use did not significantly predict AARC-losses, nor ATOA at follow-up, whereas lower levels of AARC-losses and more positive ATOA predicted more frequent social media use at follow-up.

Discussion
Although effect sizes were small, decreasing negative views on aging may help increase the engagement of middle-aged and older people with social media. At the same time, fostering social media use could promote positive self-perceptions of aging.
Distribution and biomass estimation of Antarctic krill (Euphausia superba) off the South Orkney Islands during 2011–2020
Authors: Skaret G , Macaulay G J , Pedersen R , Wang X , Klevjer T A , Krag L A , Krafft B A 
Published: May 2023

Abstract
Antarctic krill is a key species in the Southern Ocean and subject to the most extensive fishery in the Antarctic. The Norwegian Institute of Marine Research has conducted acoustic-trawl monitoring of krill off the South Orkneys annually since 2011 in collaboration with the krill fishing industry. Average krill biomass within the 60000 km2 survey area ranged from 1.4 to 7.8 million tonnes in the period 2011–2020, strongly supporting that this is among the regions in the Scotia Sea with consistently highest krill densities. There were no significant (p ≈ 0.18, non-parametric Mann–Kendall test) monotonic trends in estimated krill biomass over the 10 years. The highest krill densities were associated with the shelf edge and submarine canyons on the north side of the South Orkneys. Our comparison with the CCAMLR 9.3% reference exploitation rate suggests that management of the krill fishery in the South Orkneys region is precautionary. The monitoring is run on fishing vessels, so e.g. acoustic frequencies applied could not always be in compliance with the standard CCAMLR methodology. Estimated deviance in krill backscatter when comparing 38 kHz to the standard 120 kHz ranged from −1.1% to 12.8%. Our results show that industry-based surveys are cost-efficient approaches to high-quality monitoring of krill.
Intake of sugary beverages with chronic conditions and multimorbidity: a prospective cohort study of UK Biobank
Authors: Zhang Yue , Chen Hui , Lim Carmen C W , Carrillo-Larco Rodrigo M , Yan Lijing L , Mishra Gita D , Yuan Changzheng , Xu Xiaolin 
Published: May 2023

Abstract

Background
The burden of chronic conditions associated with sugary beverages is increasing but little is known about the role of different types of sugary beverages in the co-occurrence of multiple chronic conditions (‘multimorbidity’). To inform future sugar-reduction guidelines, we aimed to examine the associations of sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB) and natural juices (NJ) with multimorbidity.

Methods
This prospective cohort study included 184 093 UK Biobank participants aged 40–69 years at baseline who completed at least one occasion of 24-h dietary recall between 2009 and 2012. Daily consumptions of SSB, ASB and NJ were assessed using 24-h dietary recall. Participants were followed from the first 24-h assessment until the onset of two or more new chronic conditions, or the end of follow-up (31 March 2017), whichever occurred first. Logistic regression models, Cox proportional hazard models and quasi-Poisson mixed effects models were used to estimate the association of beverages intakes with chronic conditions and multimorbidity.

Results
A total of 19 057 participants had multimorbidity at baseline and 19 968 participants developed at least two chronic conditions during follow-up. We observed dose–response relationships of SSB and ASB consumptions with the prevalence and incidence of multimorbidity. For example, the adjusted hazard ratios (HRs) and 95% CIs of the incidence of developing at least two chronic conditions ranged from 1.08 (1.01–1.14) for SSB intake of 1.1–2 units/day to 1.23 (1.14–1.32) for &gt;2 units/day compared with 0 units/day. Also, the adjusted HRs (95% CIs) of ASB consumption ranged from 1.08 (1.03–1.13) for 0.1–1 unit/day to 1.28 (1.17–1.40) for &gt;2 units/day compared with non-consumers. Conversely, moderate consumption of NJ was associated with a smaller risk of the prevalence and incidence of multimorbidity. Moreover, higher intakes of SSB and ASB were positively associated whereas moderate intake of NJ was inversely associated with increased number of new-onset chronic conditions during follow-up.

Conclusions
Higher SSB and ASB intakes were positively associated whereas moderate NJ intake was inversely associated with the higher risk of multimorbidity and increased number of chronic conditions. Current and intended policy options to decrease the burden of chronic conditions and multimorbidity need a formulation of SSB and ASB reduction strategies.
Approximately low-rank recovery from noisy and local measurements by convex program
Authors: Lee Kiryung , Sharma Rakshith Srinivasa , Junge Marius , Romberg Justin 
Published: May 2023

Abstract
Low-rank matrix models have been universally useful for numerous applications, from classical system identification to more modern matrix completion in signal processing and statistics. The nuclear norm has been employed as a convex surrogate of the low-rankness since it induces a low-rank solution to inverse problems. While the nuclear norm for low rankness has an excellent analogy with the $\ell _1$ norm for sparsity through the singular value decomposition, other matrix norms also induce low-rankness. Particularly as one interprets a matrix as a linear operator between Banach spaces, various tensor product norms generalize the role of the nuclear norm. We provide a tensor-norm-constrained estimator for the recovery of approximately low-rank matrices from local measurements corrupted with noise. A tensor-norm regularizer is designed to adapt to the local structure. We derive statistical analysis of the estimator over matrix completion and decentralized sketching by applying Maurey’s empirical method to tensor products of Banach spaces. The estimator provides a near-optimal error bound in a minimax sense and admits a polynomial-time algorithm for these applications.
A comparison of phenotypic and WGS drug susceptibility testing in Mycobacterium tuberculosis isolates from the Republic of Korea
Authors: Lee Seung Heon , Ferran Elena , Witney Adam A , Ryu Sungweon , Kang Hyungseok , Storey Nathaniel , McHugh Timothy D , Satta Giovanni 
Published: May 2023

Abstract

Background
WGS has significant potential to help tackle the major public health problem of TB. The Republic of Korea has the third highest rates of TB of all Organisation for Economic Cooperation and Development countries but there has been very limited use of WGS in TB to date.

Objectives
A retrospective comparison of Mycobacterium tuberculosis (MTB) clinical isolates from 2015 to 2017 from two centres in the Republic of Korea using WGS to compare phenotypic drug susceptibility testing (pDST) and WGS drug susceptibility predictions (WGS-DSP).

Methods
Fifty-seven MTB isolates had DNA extracted and were sequenced using the Illumina HiSeq platform. The WGS analysis was performed using bwa mem, bcftools and IQ-Tree; resistance markers were identified using TB profiler. Phenotypic susceptibilities were carried out at the Supranational TB reference laboratory (Korean Institute of Tuberculosis).

Results
For first-line antituberculous drugs concordance for rifampicin, isoniazid, pyrazinamide and ethambutol was 98.25%, 92.98%, 87.72% and 85.96%, respectively. The sensitivity of WGS-DSP compared with pDST for rifampicin, isoniazid, pyrazinamide and ethambutol was 97.30%, 92.11%, 78.95% and 95.65%, respectively. The specificity for these first-line antituberculous drugs was 100%, 94.74%, 92.11% and 79.41%, respectively. The sensitivity and specificity for second-line drugs ranged from 66.67% to 100%, and from 82.98% to 100%, respectively.

Conclusions
This study confirms the potential role for WGS in drug susceptibility prediction, which would reduce turnaround times. However, further larger studies are needed to ensure current databases of drug resistance mutations are reflective of the TB present in the Republic of Korea.
Role of non-coding RNAs in tuberculosis and their potential for clinical applications
Authors: Jumat Mohd Iskandar , Sarmiento Maria E , Acosta Armando , Chin Kai Ling 
Published: May 2023

AbstractTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of mortality due to infectious diseases, only surpassed in 2020 by COVID-19. Despite the development in diagnostics, therapeutics, and evaluation of new vaccines for TB, this infectious disease remains uncontrollable due to the emergence of multidrug-resistant (MDR) and extremely drug-resistant (XDR) TB, among other factors. The development in transcriptomics (RNomics) has enabled the study of gene expression in TB. It is considered that non-coding RNAs (ncRNAs) from host [microRNAs (miRNAs)] and Mtb [small RNAs (sRNAs)] are important elements in TB pathogenesis, immune resistance, and susceptibility. Many studies have shown the importance of host miRNAs in regulating immune response against Mtb via in vitro and in vivo mice models. The bacterial sRNAs play a major role in survival, adaptation, and virulence. Here, we review the characterization and function of host and bacteria ncRNAs in TB and their potential use in clinical applications as diagnostic, prognostic, and therapeutic biomarkers.
Developing and validating a natural language processing algorithm to extract preoperative cannabis use status documentation from unstructured narrative clinical notes
Authors: Sajdeya Ruba , Mardini Mamoun T , Tighe Patrick J , Ison Ronald L , Bai Chen , Jugl Sebastian , Hanzhi Gao , Zandbiglari Kimia , Adiba Farzana I , Winterstein Almut G , Pearson Thomas A , Cook Robert L , Rouhizadeh Masoud 
Published: May 2023

Abstract

Objective
This study aimed to develop a natural language processing algorithm (NLP) using machine learning (ML) techniques to identify and classify documentation of preoperative cannabis use status.

Materials and Methods
We developed and applied a keyword search strategy to identify documentation of preoperative cannabis use status in clinical documentation within 60 days of surgery. We manually reviewed matching notes to classify each documentation into 8 different categories based on context, time, and certainty of cannabis use documentation. We applied 2 conventional ML and 3 deep learning models against manual annotation. We externally validated our model using the MIMIC-III dataset.

Results
The tested classifiers achieved classification results close to human performance with up to 93% and 94% precision and 95% recall of preoperative cannabis use status documentation. External validation showed consistent results with up to 94% precision and recall.

Discussion
Our NLP model successfully replicated human annotation of preoperative cannabis use documentation, providing a baseline framework for identifying and classifying documentation of cannabis use. We add to NLP methods applied in healthcare for clinical concept extraction and classification, mainly concerning social determinants of health and substance use. Our systematically developed lexicon provides a comprehensive knowledge-based resource covering a wide range of cannabis-related concepts for future NLP applications.

Conclusion
We demonstrated that documentation of preoperative cannabis use status could be accurately identified using an NLP algorithm. This approach can be employed to identify comparison groups based on cannabis exposure for growing research efforts aiming to guide cannabis-related clinical practices and policies.
Reducing False Negatives in Biopsy of Suspicious MRI Findings
Authors: Wang Lilian C , Rao Sandra , Schacht David , Bhole Sonya 
Published: May 2023

Abstract
Breast MRI is a highly sensitive imaging modality that often detects findings that are occult on mammography and US. Given the overlap in appearance of benign and malignant lesions, an accurate method of tissue sampling for MRI-detected findings is essential. Although MRI-directed US and correlation with mammography can be helpful for some lesions, a correlate is not always found. MRI-guided biopsy is a safe and effective method of tissue sampling for findings seen only on MRI. The unique limitations of this technique, however, contribute to false negatives, which can result in delays in diagnosis and adverse patient outcomes; this is of particular importance as most MRI examinations are performed in the high-risk or preoperative setting. Here, we review strategies to minimize false negatives in biopsy of suspicious MRI findings, including appropriate selection of biopsy modality, use of meticulous MRI-guided biopsy technique, management after target nonvisualization, assessment of adequate lesion sampling, and determination of radiology-pathology concordance. A proposed management algorithm for MRI-guided biopsy results will also be discussed.
Probe-based quantitative PCR and RPA-Cas12a molecular diagnostics for detection of the tomato pest Phthorimaea absoluta (Lepidoptera: Gelechiidae)
Authors: Lewald Kyle M , Song Wenqi , Eweis-LaBolle Daniel , Truong Cindy , Godfrey Kristine E , Chiu Joanna C 
Published: May 2023

Abstract
The tomato pest Phthorimaea absoluta Meyrick is highly invasive but has not yet invaded North America. However, several morphologically similar species are already present, making detection of P. absoluta presence and invasion challenging. We designed a quantitative PCR molecular diagnostic to differentiate P. absoluta, P. operculella (Zeller), or Keiferia lycopersicella (Walsingham) (Lepidoptera: Gelechiidae) DNA. Additionally, we developed an RPA-Cas12a molecular diagnostic that allows for the isothermal detection of P. absoluta DNA, eliminating the need for a thermocycler. The results of the RPA-Cas12a diagnostic can be visualized simply using a UV light source and cell phone camera. We expect these diagnostics to improve quarantine and prevention measures against this serious agricultural threat.
Removing neonicotinoid seed treatments has negligible effects on refuge function and crop protection in transgenic maize targeting western corn rootworm (Coleoptera: Chrysomelidae)
Authors: Bekelja Kyle M , Miller Kathleen M , Kuhar Thomas P , Krupke Christian H , Taylor Sally V 
Published: May 2023

Abstract
Nearly all maize seed sold in the United States includes a neonicotinoid seed treatment (NST), meant to protect seedlings against early-season insect pests. For key pests, including western corn rootworm (Diabrotica virgifera virgifera LeConte) (D.v.v), insecticidal proteins derived from Bacillus thuringiensis (Bt) are expressed in plant tissues as alternatives to soil-applied insecticides. Insect resistance management (IRM) plans use non-Bt “refuges” to encourage survival of Bt-susceptible D.v.v., which maintains susceptible alleles in the population. In non-cotton producing regions, IRM guidelines require a minimum 5% blended refuge for maize expressing more than 1 trait targeting D.v.v. Prior work has shown that 5% blends yield insufficient proportions of refuge beetles to contribute reliably to IRM. Whether NSTs interfere with survivorship of refuge beetles is unknown. Our objective was to determine whether NSTs affect proportions of refuge beetles, and secondarily, to determine whether NSTs provide agronomic advantages over Bt seed alone. To reveal host plant type (i.e., Bt or refuge), we used a stable isotope (15N) to mark refuge plants in plots with 5% seed blends. To assess refuge performance between treatments, we compared proportions of beetles from respective natal hosts. In all site-years, NSTs showed inconsistent effects on proportions of refuge beetles. Treatment comparisons showed inconsistent agronomic benefits of NSTs when combined with Bt traits. Our results demonstrate that NSTs have a negligible impact on refuge performance and reinforces the assertion that 5% blends are serving little benefit for IRM. Plant stand and yield were not improved by NSTs.
The Blessed Tree in the works of Ibn Barrajān of Seville (d. 536/1141)
Authors: Jaffe Sam , Casewit Yousef 
Published: May 2023

Abstract
In his commentary on the Light Verse (Q. 24:35), the Andalusian mystic and Qurʾān exegete Abū al-Ḥakam Ibn Barrajān (d. 1141) presents the blessed tree (al-shajara al-mubāraka) not simply as a terrestrial olive tree in Syria or even as a mystical allegory, but as the ultimate locus of divine disclosure and the highest metaphysical entity in the cosmos that subsumes the world of creation. This article assesses the originality of Ibn Barrajān’s contribution to the heavenly tree motif by examining his unique mystical and exegetical theories informing his ontological reading of the blessed tree, including the concept of the ‘reality upon which creation is created’ and the ‘universal servant’. In addition to analysing the internal logic of Ibn Barrajān’s discourse, this article explores the larger interpretive themes recurrent across exoteric, Sufi, and philosophical interpretations of the Light Verse up to the twelfth century that the author may have had access to in al-Andalus, including the treatises of the Brethren of Purity (Ikhwān al-ṣafā) and Biblical sources. Finally, this article highlights how Ibn Barrajān weaves the Qurʾānic good tree (al-shajara al-ṭayyiba) and the lote tree of the furthest boundary (sidrat al-muntahā) into his overarching understanding of the blessed tree. It also considers how his reading may have contributed to later readings by Ibn ʿArabī (d. 1240) and some of his intellectual heirs.
Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway
Authors: Li Jing , Hu Guanying , Liu Wenxiu , Cao Xiaoyu , Chen Guanru , Peng Fu , Xiaofang Xie , Peng Cheng 
Published: May 2023

Abstract

Objectives
The present study was designed to obverse the protection of patchouli alcohol (PA) ameliorates hypertensive nephropathy in spontaneously hypertensive rats (SHR) and reveals potential mechanism.

Methods
Briefly, the adult spontaneously hypertensive rats (SHR) or Wistar–Kyoto (WKY) rats (half male and half female) were intragastric gavaged or not with PA (80, 40 and 20 mg/kg) for 8 weeks. Body weight, blood pressure (BP), renal weight, renal function and renal morphology were measured. Further, western blotting and immunohistochemical analysis were used to study the underlying mechanism.

Key findings
Compared with the WKY group, plasmatic levels of renin, angiotensin II (Ang-II), transforming growth factor beta 1(TGF-β1), plasminogen activator inhibitor-1(PAI-1), creatinine (Cr), blood urea nitrogen (BUN), renal index, mRNA levels of ERK1/2 and α-SMA were significantly increased in SHR. Histology results showed that renal tubular injury and tubulointerstitial fibrosis occurred in SHR. After administration, SBP of captopril group decreased at each week after administration, especially at 3, 5, 6 7 and 8 weeks (P &lt; 0.05 or P &lt; 0.01). There is no significant effect was assessed in the olive oil group. Decreased plasma Cr, Renin, Ang-II, TGF-β1, PAI-1, SCFAs and Renin, TGF-β1, PAI-1 in renal tissues were observed significantly in captopril (P &lt;0.05 or P &lt; 0.01). Plasma BUN, Ang-II, TGF-β1 and PAI-1 in renal tissues decreased in the olive oil group significantly (P &lt;0.05 or P &lt; 0.01). PA (80, 40 and 20 mg/kg) lowered BP and plasmatic levels of Renin, Ang-II, TGF-β1 and PAI-1. Treatment with PA (40, 20 mg/kg) decreased levels of Cr, BUN and suppressed of activation of pro-fibrosis cytokines including TGF-β1 in kidney. There is no ameliorative change in the olive oil group and the captopril group (P &gt; 0.05) while PA treatment alleviated renal tubular injury and produced dramatic collagen fibre area reductions in mesangial membrane, basement membrane, and renal interstitium obviously (P &lt; 0.05 or P &lt; 0.01). Treatment of SHR with PA-inhibited MFB activation and downregulated mRNA of α-SMA. Treatment with PA suppressed excessive production of the extracellular matrix (ECM) via decreasing Col I, III and FN, downregulating mRNA of tissue inhibitor of TIMP-1 along with upregulating mRNA of MMP-9. The expression of Col III and MMP-9 mRNA-reduced in the captopril group (P &lt; 0.05). In addition, the expression of ERK1/2 and pERK1/2 also reduced in the captopril group significantly (P &lt; 0.05 or P &lt; 0.01). Treatment with PA (20 mg/kg) downregulated proteins expression of Raf-1, ERK1/2 and pERK1/2 and mRNA expression of Ras, Raf-1 and ERK1/2.

Conclusions
Overall, PA restored normal BP, alleviated renal dysfunction and renal fibrosis, possibly by suppressing Ang II and TGF-β1-mediated Ras/Raf-1/ERK1/2 signalling pathway.
Milky pericardial effusion causing tamponade in a neonate after extracorporeal membrane oxygenation cannulation
Authors: Thornhill Rosanne , Fortuna Randall , Canteras Kayla , Raymond Steven L , Khan Faraz A , Radulescu Andrei 
Published: May 2023

Abstract
Cardiac tamponade is a known life-threatening complication of extracorporeal membrane oxygenation (ECMO), often secondary to hemopericardium from major vascular or cardiac perforation. We present the unique case of a neonate with a milky pericardial effusion causing tamponade after ECMO cannulation, managed successfully with pericardial window. Understanding ECMO physiology and its effect on the classic presentation of tamponade is critical and can prevent delays in diagnosis. While hemopericardium is most commonly seen in these cases, findings of a non-bloody, milky effusion should prompt further workup for infection, chylopericardium or total parenteral nutrition-associated pericardial effusion, as the appropriate management can mitigate immediate and potential long-term sequelae.