bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child Welfare System-Level Factors Associated with All-Cause Mortality Among Children in Foster Care in the United States, 2009–2018
Authors: Lee Joyce Y. , Steelesmith Danielle L. , Chaiyachati Barbara H. , Kirsch Jaclyn , Rao Smitha , Fontanella Cynthia A. 
Published: May 2023

Little is known about the impact of child welfare system-level factors on child mortality as an outcome within foster care. Using data from the Adoption and Foster Care Analysis and Reporting System, 2009–2018, we examined the associations between county-level sociodemographic, foster care performance, and judicial reform characteristics with all-cause mortality rates. Results of random effects negative binomial regression analyses showed that higher proportions of younger children (<1 year: IRR = 1.06, 95% CI [1.02, 1.11]; 5–9 years: IRR = 1.05, 95% CI [1.01, 1.09]); children of color (i.e., non-Hispanic Asian: IRR = 1.07, 95% CI [1.01, 1.13]; multiracial: IRR = 1.03, 95% CI [1.01, 1.04]; non-Hispanic Black: IRR = 1.02, 95% CI [1.01, 1.02]; Hispanic: IRR = 1.01, 95% CI [1.01, 1.02]); and male children (IRR = 1.10, 95% CI [1.05, 1.15]) were associated with higher mortality risks at the county level. Current class action lawsuits (IRR = 0.79, 95% CI [0.63, 0.99]) and active consent decrees (IRR = 0.77, 95% CI [0.63, 0.94]) were associated with lower mortality risks. None of the foster care performance characteristics (e.g., foster care entry, placement stability, permanency) were associated with mortality risks. These findings have implications for addressing health disparities and reforming foster care systems through programmatic and policy efforts.
Comprehensive Surveillance of Dance Injuries a Proposal for Uniform Reporting Guidelines for Professional Companies
Authors: Bronner Shaw , Ojofeitimi Sheyi , Mayers Lester 
Published: May 2023

Varying methods of injury definition, data collection and interpretation of findings complicate analysis of results from epidemiological studies of sport and dance injuries. Comparison between studies is therefore difficult. Researchers have suggested adoption of uniform methodology for injury definition and reporting. This paper outlines a suggested comprehensive injury reporting system for professional dance companies.Components of a comprehensive injury surveillance system include: 1. pre-season screening of intrinsic risk factors, 2. extrinsic risk factor tracking, and 3. injury occurrence reporting system. Dance screens provide healthy baseline data, uncover existing pathology, and help define population characteristics. Extrinsic risk factor tracking includes quantification of exposure to specific environment, equipment, and technique demands. Exposure may be delineated as activity (number of performance, class, and rehearsal events) or time (hours of participation in dance activities) based. These exposure measures are then incorporated into incidence calculations, enabling injury rate comparison between populations.Standardized injury definitions are proposed to facilitate the comparison of injury rates. We propose defining “injury” as any physical complaint sustained by a dancer resulting from performance, rehearsal, or technique class. Injury is further delineated in the following ways: 1. physical complaint injury, 2. medical injury, 3. time-loss injury, and 4. financial injury. Coding by severity, injury type, location, tissue, activity, and style of dance and choreography is also included. We hope this may ultimately result in uniform injury registration for dancers of all ages and levels. Adoption of a common system should result in improved understanding of injury incidence and risk factors with potential to increase the effectiveness of injury prevention interventions and rehabilitation.
Biomechanics of the Foot in Dance: A Literature Review
Authors: Ahonen Jarmo 
Published: May 2023

In any form of dance, great strain is placed on the lower extremity and the strong but sensitive foot. A large percentage of injuries to dancers involve the foot and ankle. Understanding the structure, biomechanics, and physics of the lower extremity helps to diagnose and evaluate the mechanics behind these injuries.The lower extremity function is complicated and needs to be studied carefully to understand its laws and principles. What often happens when injury occurs is that the dancer is not satisfying the natural requirements of movement through the joints. For example, her relevé is causing sickling and unstable foot positions because the forefoot is not strong enough and the leg external rotation and hip joint muscular support are not simultaneous with the heel raise. In the opposite direction, when the dancer is executing plié, the outcome of poor control of a weakened foot is strain on the passive supporting structures, such as the plantar ligaments, joint capsules, and plantar fascia. This leads to faulty bone alignment, increased bone load, and risk of overuse syndromes in various tissues.
Health Care Seeking Behavior and Perceptions of the Medical Profession among Pre- and Post-Retirement Age Dutch Dancers
Authors: Air Mamie 
Published: May 2023

A cross-sectional, descriptive survey and a medical chart review of 154 pre- and post-retirement age injured Dutch dancers were performed. The purpose was to examine dancers’ health care seeking behavior and perceptions of the medical profession in context of the current health care system in The Netherlands, which includes both universal access and expertise in performing arts medicine. No logistical or perceptual restrictions to health care were reported by the dancers in this study. Only three younger dancers (< 35 years) lacked a primary care physician. No dancer reported monetary or insurance hindrances to acquiring an appointment or fear of going to the doctor. A small percentage of the younger group (18%), but none of the older dancers, reported that they felt the doctor would not understand them (χ2= 2.2, df = 1, p = 0.14). Dancers in both age groups most often sought first treatment from either a physiotherapist (36% to 40%) or a medical doctor (38.8% to 40.8%). When a physician was not consulted first, the primary reason was that dancers had already seen a physiotherapist and thought this treatment was sufficient. Approximately one-third of dancers expected their medical problem to go away on its own.Dutch dancers were additionally found to have a positive relationship with the medical profession, including high satisfaction and confidence. The majority of dancers were satisfied or very satisfied with their medical treatment prior to presenting to the dance medicine specialist (67% older dancers, 52% younger, χ2= 1.19, df = 1, p = 0.2). Nearly every dancer was satisfied or very satisfied after treatment by the specialist (100% older dancers, 93% younger dancers, χ2= 1.46, df = 1, p = 0.2), and moderately or completely confident of full recovery (80%, each group).Differences in older and younger dancers’ perceptions and behaviors were nevertheless found. Older dancers were significantly more likely to continue to dance when injured than younger dancers (100% versus 82%, χ2= 5.14, df = 1, p = 0.02), although pain and perceived level of artistic hindrance were similar between the groups at first presentation to a dance medicine clinic (pain: 32.6 versus 34.0 mm, respectively, p = 0.83; artistic hindrance: 49.3 versus 58.0 mm, p = 0.29, respectively). Older dancers were more likely to wait and see for themselves whether an injury would get better by itself (14% versus 4%, χ2= 4.1, df = 1, p = 0.05). Average time to seek treatment from a medical doctor was four times longer among older than younger dancers (8.4 versus 2.1 months, respectively, p = 0.004), and older dancers had less confidence in full recovery at first visit (40% versus 61%, χ2= 3.8, df = 1, p = 0.05).Thus, the medical system of The Netherlands is one that confers improved health care access and perceptions of the medical profession among dancers, yet there remain areas to be addressed in terms of equalization of health care delivery.
Dancer Disordered Eating
Authors: Culnane Catherine , Deutsch Donna 
Published: May 2023

The purpose of this study was to assess nutritional status; to examine the prevalence of disordered eating behavior; and to determine if a relationship existed between nutritional status and disordered eating behavior among female dancers. Twenty-one female dance majors from the undergraduate dance department at a major northeastern university participated in the survey which included: three-day food and activity records from the DINE U.S. nutritional program; EAT-26 eating attitudes assessment; and University Dancer Profile (UDP), an instrument designed by the principal researcher. On the EAT-26, 4 out of 21 subjects (19%) scored in eating disorder symptomatic range. The group means for the DINE U.S. nutritional subscales were below recommended levels: caloric intake, 59% (SD = 17.6); protein, 75% (SD = 20.9); calcium, 48% (SD = 19.8); iron, 63% (SD = 27.8); and phosphorus, 80% (SD = 24.7). A Fisher Exact Test for Significance in a 2 x 2 Contingency Table confirmed no significant relationship between disordered eating behavior and nutritional status. On the UDP, 76% of the sample scored in the Body Dissatisfaction range. We can conclude, therefore, that the sample population has normal eating attitudes, yet is preoccupied with body weight and shape, and that the subjects restrict their caloric intake. The results of this study indicate that the female dance population may be at risk for developing subclinical eating disorders within the dance subculture, or Dancer Disordered Eating.
PLU1 Promotes the Proliferation and Migration of Glioma Cells and Regulates Metabolism
Authors: Dong Wentao , Wang Lude , Pan Yi , Tu Qi , He Ting , Zhou Tian , Yuan Jianlie , Tong Minfeng 
Published: May 2023

Objectives PLU1 is upregulated in many cancers, including breast, mammary, colorectal, and hepatocellular carcinoma. However, little is known about the potential metabolic mechanisms of PLU1 in glioma progression. Therefore, we investigated the relationship between PLU1 and glioma development. Methods We analyzed the relationship between PLU1 expression and World Health Organization (WHO) grade using clinical databases and verified the role of PLU1 in glioma development using transcriptome sequencing, Western blotting, Cell Counting Kit 8, colony formation, and wound healing assays. The relationship between PLU1 and glioma glucose metabolism was also initially explored by changing the concentration of glucose in the culture medium and was validated by metabolomics and energy metabolism. Result PLU1 expression was closely related to WHO grade and was significantly elevated in tumor tissues compared to nontumor tissues. Knockdown or inhibition of PLU1 inhibits proliferation and migration of glioma cells. In addition, we found that PLU1 expression was closely associated with glioma metabolism by transcriptomic, metabolomic, and energy-related molecular analyses and correlated with glucose metabolism. We also found that glucose concentration affects PLU1 expression, and that PLU1 expression affects intracellular glucose levels. Conclusion PLU1 is a novel regulator of metabolic reprograming and a novel strategy for the treatment of glioma.
Baseline evaluation of nursing students’ informatics competency for digital health practice: A descriptive exploratory study
Authors: Raghunathan Kalpana , McKenna Lisa , Peddle Monica 
Published: May 2023

Introduction The healthcare system is increasingly technology-dependent and proficiency in informatics skills is essential for health professionals to efficiently operate in the contemporary clinical environment. Nurses are major users of digital health technologies and graduates need to be well-prepared and confident to use the different available clinical systems competently as they transition from education to practice. Aim To explore undergraduate nursing students’ self-perceptions of informatics competence, set within a larger research project. Method Descriptive, exploratory cross-sectional research design, with online self-assessment survey of undergraduate nursing students ( n  =  142). Data were analysed with descriptive, correlation and comparative statistics. Results Participants’ perceived overall mean informatics competency was at the level of somewhat competent, with only 40.84% ( n  =  58) at the level of competent. The highest mean value was in foundational information and communication skills and the lowest in information and knowledge management. Formal informatics education within curriculum was limited and lacked uniformity, as was prior exposure to important simulated informatics tools in preparation for practice. Factors including academic year level, computer experience and previous experience using clinical systems had a significant impact on participants’ perceived informatics competency. Conclusion Even though informatics competence is vital for clinical practice, with technology becoming pervasive within healthcare, nursing students’ preparedness for digital health was sub-optimal. There were gaps in students’ critical informatics practice knowledge with implications for work readiness of future graduates and nurse education practice.
Schottky barrier height engineering on MoS2 field-effect transistors using a polymer surface modifier on a contact electrode
Authors: Choi Dongwon , Jeon Jeehoon , Park Tae-Eon , Ju Byeong-Kwon , Lee Ki-Young 
Published: May 2023

AbstractTwo-dimensional (2D) materials are highly sought after for their superior semiconducting properties, making them promising candidates for next-generation electronic and optoelectronic devices. Transition-metal dichalcogenides (TMDCs), such as molybdenum disulfide (MoS2) and tungsten diselenide (WSe2), are promising alternative 2D materials. However, the devices based on these materials experience performance deterioration due to the formation of a Schottky barrier between metal contacts and semiconducting TMDCs. Here, we performed experiments to reduce the Schottky barrier height of MoS2 field-effect transistors (FETs) by lowering the work function (Фm = Evacuum − EF,metal) of the contact metal. We chose polyethylenimine (PEI), a polymer containing simple aliphatic amine groups (–NH2), as a surface modifier of the Au (ФAu = 5.10 eV) contact metal. PEI is a well-known surface modifier that lowers the work function of various conductors such as metals and conducting polymers. Such surface modifiers have thus far been utilized in organic-based devices, including organic light-emitting diodes, organic solar cells, and organic thin-film transistors. In this study, we used the simple PEI coating to tune the work function of the contact electrodes of MoS2 FETs. The proposed method is rapid, easy to implement under ambient conditions, and effectively reduces the Schottky barrier height. We expect this simple and effective method to be widely used in large-area electronics and optoelectronics due to its numerous advantages.
Accelerating genomic workflows using NVIDIA Parabricks
Authors: O’Connell Kyle A. , Yosufzai Zelaikha B. , Campbell Ross A. , Lobb Collin J. , Engelken Haley T. , Gorrell Laura M. , Carlson Thad B. , Catana Josh J. , Mikdadi Dina , Bonazzi Vivien R. , Klenk Juergen A. 
Published: May 2023

Abstract
Background
As genome sequencing becomes better integrated into scientific research, government policy, and personalized medicine, the primary challenge for researchers is shifting from generating raw data to analyzing these vast datasets. Although much work has been done to reduce compute times using various configurations of traditional CPU computing infrastructures, Graphics Processing Units (GPUs) offer opportunities to accelerate genomic workflows by orders of magnitude. Here we benchmark one GPU-accelerated software suite called NVIDIA Parabricks on Amazon Web Services (AWS), Google Cloud Platform (GCP), and an NVIDIA DGX cluster. We benchmarked six variant calling pipelines, including two germline callers (HaplotypeCaller and DeepVariant) and four somatic callers (Mutect2, Muse, LoFreq, SomaticSniper).

Results
We achieved up to 65 × acceleration with germline variant callers, bringing HaplotypeCaller runtimes down from 36 h to 33 min on AWS, 35 min on GCP, and 24 min on the NVIDIA DGX. Somatic callers exhibited more variation between the number of GPUs and computing platforms. On cloud platforms, GPU-accelerated germline callers resulted in cost savings compared with CPU runs, whereas some somatic callers were more expensive than CPU runs because their GPU acceleration was not sufficient to overcome the increased GPU cost.

Conclusions
Germline variant callers scaled well with the number of GPUs across platforms, whereas somatic variant callers exhibited more variation in the number of GPUs with the fastest runtimes, suggesting that, at least with the version of Parabricks used here, these workflows are less GPU optimized and require benchmarking on the platform of choice before being deployed at production scales. Our study demonstrates that GPUs can be used to greatly accelerate genomic workflows, thus bringing closer to grasp urgent societal advances in the areas of biosurveillance and personalized medicine.
Identification and functional characterization of the dirigent gene family in Phryma leptostachya and the contribution of PlDIR1 in lignan biosynthesis
Authors: Pei Yakun , Cao Wenhan , Yu Wenwen , Peng Chaoyang , Xu Wenhao , Zuo Yayun , Wu Wenjun , Hu Zhaonong 
Published: May 2023

Abstract
Background
Furofuran lignans, the main insecticidal ingredient in Phryma leptostachya, exhibit excellent controlling efficacy against a variety of pests. During the biosynthesis of furofuran lignans, Dirigent proteins (DIRs) are thought to be dominant in the stereoselective coupling of coniferyl alcohol to form ( ±)-pinoresinol. There are DIR family members in almost every vascular plant, but members of DIRs in P. leptostachya are unknown. To identify the PlDIR genes and elucidate their functions in lignan biosynthesis, this study performed transcriptome-wide analysis and characterized the catalytic activity of the PlDIR1 protein.

Results
Fifteen full-length unique PlDIR genes were identified in P. leptostachya. A phylogenetic analysis of the PlDIRs classified them into four subfamilies (DIR-a, DIR-b/d, DIR-e, and DIR-g), and 12 conserved motifs were found among them. In tissue-specific expression analysis, except for PlDIR7, which displayed the highest transcript abundance in seeds, the other PlDIRs showed preferential expression in roots, leaves, and stems. Furthermore, the treatments with signaling molecules demonstrated that PlDIRs could be significantly induced by methyl jasmonate (MeJA), salicylic acid (SA), and ethylene (ETH), both in the roots and leaves of P. leptostachya. In examining the tertiary structure of the protein and the critical amino acids, it was found that PlDIR1, one of the DIR-a subfamily members, might be involved in the region- and stereo-selectivity of the phenoxy radical. Accordingly, LC–MS/MS analysis demonstrated the catalytic activity of recombinant PlDIR1 protein from Escherichia coli to direct coniferyl alcohol coupling into ( +)-pinoresinol. The active sites and hydrogen bonds of the interaction between PlDIR1 and bis-quinone methide (bisQM), the intermediate in ( +)-pinoresinol formation, were analyzed by molecular docking. As a result, 18 active sites and 4 hydrogen bonds (Asp-42, Ala-113, Leu-138, Arg-143) were discovered in the PlDIR1-bisQM complex. Moreover, correlation analysis indicated that the expression profile of PlDIR1 was closely connected with lignan accumulations after SA treatment.

Conclusions
The results of this study will provide useful clues for uncovering P. leptostachya's lignan biosynthesis pathway as well as facilitate further studies on the DIR family.
Protective role of nitric oxide donors on endothelium in ischemia-reperfusion injury: a meta-analysis of randomized controlled trials
Authors: Dou Chaoxun , Han Xue , Xie Hanbin , Liao Haofeng , Xiao Xue , Huang Ziyan , Luo Gangjian , Zhang Xinmin , Yao Weifeng 
Published: May 2023

Abstract
Background
Decreased bioavailability of nitric oxide (NO) under hypoxic conditions can lead to endothelial dysfunction. NO supplementation may protect endothelial function in ischemia-reperfusion (IR) injury. Therefore, a meta-analysis of randomized controlled trials (RCTs) was performed to verify the protective effect of NO donors on endothelium in IR injury.

Methods
Medline, Embase, Cochrane Library, and Web of Science databases were searched from inception to April 1, 2023. The specific inclusion criteria were as follows: (1) RCTs; (2) trials comparing NO donors with placebo control groups; and (3) trials reporting the effects of these interventions on vascular endothelial functional outcomes in IR injury. Random-effects models were used to assess pooled effect sizes, which were expressed as standardized mean differences (SMD).

Results
Seven studies satisfied the inclusion criteria and consisted of a total of 149 participants. NO donors were protective of endothelial function in IR injury (SMD: − 1.60; 95% confidence interval [CI]: − 2.33, − 0.88, P < 0.0001; heterogeneity [I2 = 66%, P = 0.001]). Results of the subgroup analysis showed the following: absence of protective effect of NO donor use following ischemia on endothelial function in IR injury − 1.78 (95% CI: − 2.50, − 1.07) and loss of protective effect on endothelial function after prolonged NO donor use − 0.89 (95% CI: − 2.06, 0.28).

Conclusion
The short-period use of NO donors before the onset of ischemia can protect endothelial function in IR injury.
Integrated analysis of clinical and genetic factors on the interindividual variation of warfarin anticoagulation efficacy in clinical practice
Authors: Sun Bao , Ma Siqing , Xiao Feiyan , Luo Jianquan , Liu Mouze , Liu Wenhui , Luo Zhiying 
Published: May 2023

Abstract
Aim
The anticoagulation effect of warfarin is usually evaluated by percentage of time in therapeutic range (PTTR), which is negatively correlated with the risk of warfarin adverse reactions. This study aimed to explore the effects of genetic and nongenetic factors on anticoagulation efficacy of warfarin during different therapeutic range.

Methods
We conducted an observational retrospective study aiming at evaluating the impact of clinical and genetic factors on PTTR from initial to more than six months treatment. This analysis included patients with heart valve replace (HVR) surgery who underwent long-term or life-long time treatment with standard-dose warfarin for anticoagulation control in Second Xiangya Hospital. All patients were followed for at least 6 months. We genotyped single nucleotide polymorphisms in VKORC1 and CYP2C9 associated with altered warfarin dose requirements and tested their associations with PTTR.

Results
A total of 629 patients with intact clinical data and available genotype data were enrolled in this study, and only 38.63% patients achieved good anticoagulation control (PTTR > 0.6). Clinical factors, including male gender, older age, overweight, AVR surgery and stroke history, were associated with higher PTTR. Patients with VKORC1 -1639AA genotype had significantly higher PTTR level compared with GA/GG genotype carriers only in the first month of treatment. Patients with CYP2C9*3 allele had higher PTTR compared with CYP2C9*1*1 carriers. Moreover, compared with VKORC1 -1639 AG/GG carriers, INR > 4 was more likely to be present in patients with AA genotype. The frequency of CYP2C9*1*3 in patients with INR > 4 was significantly higher than these without INR > 4.

Conclusion
We confirmed the relevant factors of warfarin anticoagulation control, including genetic factors (VKORC1 -1639G > A and CYP2C9*3 polymorphisms) and clinical factors (male gender, older age, overweight, AVR surgery and stroke history), which could be helpful to individualize warfarin dosage and improve warfarin anticoagulation control during different treatment period.