bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a population-based breast cancer screening in North China
Authors: Wu Siqi , Liang Di , Shi Jin , Li Daojuan , Liu Yanyu , Hao Yahui , Shi Miaomiao , Du Xinyu , He Yutong 
Published: June 2023

Abstract
Background
Despite mammography-based screening for breast cancer has been conducted in many countries, there are still little data on participation and diagnostic yield in population-based breast cancer screening in China.

Methods
We enrolled 151,973 eligible women from four cities in Hebei Province within the period 2013–2021 and followed up until December 31, 2021. Participants aged 40–74 who assessed as high risk were invited to undergo breast ultrasound and mammography examination. Overall and group-specific participation rates were calculated. Multivariable analyses were used to estimate the factors associated with participation rates. The diagnostic yield of both screening and no screening groups was calculated. We further analyzed the stage distribution and molecular subtype of breast cancer cases by different modes of cancer detection.

Results
A total of 42,547 participants were evaluated to be high risk of breast cancer. Among them, 23,009 subjects undertook screening services, with participation rate of 54.08%. Multivariable logistic regression model showed that aged 45–64, high education level, postmenopausal, current smoking, alcohol consumption, family history of breast cancer, and benign breast disease were associated with increased participation of screening. After median follow-up of 3.79 years, there were 456 breast cancer diagnoses of which 65 were screen-detected breast cancers (SBCs), 27 were interval breast cancers (IBCs), 68 were no screening cancers, and 296 were cancers detected outside the screening program. Among them, 92 participants in the screening group (0.40%) and 364 in the non-screening group (0.28%) had breast cancer detected, which resulted in an odds ratio of 1.42 (95% CI 1.13–1.78; P = 0.003). We observed a higher detection rate of breast cancer in the screening group, with ORs of 2.42 (95% CI 1.72–3.41) for early stage (stages 0–I) and 2.12 (95% CI 1.26–3.54) for luminal A subtype. SBCs had higher proportion of early stage (71.93%) and luminal A subtype (47.22%) than other groups.

Conclusions
The significant differences in breast cancer diagnosis between the screening and non-screening group imply an urgent need for increased breast cancer awareness and early detection in China.
Critical Issues of Ore Flow for the Raise Caving Method
Authors: Koch Lukas Alexander , Ladinig Tobias 
Published: June 2023

AbstractOre flow has been identified as one of the critical points of developing the novel mining method Raise Caving (RC). The focus of this contribution is on the key issues of ore-flow and on how to encounter them to enable a safe, efficient, and economic mining operation.In the de-stressing phase of RC, narrow, tabular de-stressing slots are developed via raises, only the blast swell is drawn, and hence they stay filled with blasted material at all times to support the hanging wall in order to prevent early caving and dilution ingress. To simultaneously enable a free surface at the top for blasting, the extracted amount from the bottom needs to be monitored consistently. Another point in the narrow de-stressing slots is to prevent hang-ups by an adequate slot thickness. Hang-ups in higher zones are especially critical as they are difficult to resolve and may lead to unnoticed hanging wall caving.In the following production phase, production stopes are developed in the de-stressed area behind the slots. During this phase, the stopes are always filled with blasted material as a support for the hanging wall. They are only drawn-empty at a later point after the stopes are fully established. The most important issue for production stopes is to prevent early dilution in order to extract the deposit economically. Additionally, the free surface needs to be prepared for upcoming blasts. To optimize the extraction, a uniform flow towards the draw-points needs to be created. The mentioned points can be addressed by a proper mine design and draw strategy. The parts of the mine design include the draw-point spacing, the draw-point position, and the draw-bell layout. Further on, the draw strategy must enable a uniform draw, guide the ore down the inclined stope, and prevent early dilution. The critical points mentioned in this contribution are approached by the R&D with empirical, numerical, and analytical means.
Stress monitoring using wearable sensors: IoT techniques in medical field
Authors: Talaat Fatma M. , El-Balka Rana Mohamed 
Published: June 2023

AbstractThe concept “Internet of Things” (IoT), which facilitates communication between linked devices, is relatively new. It refers to the next generation of the Internet. IoT supports healthcare and is essential to numerous applications for tracking medical services. By examining the pattern of observed parameters, the type of the disease can be anticipated. For people with a range of diseases, health professionals and technicians have developed an excellent system that employs commonly utilized techniques like wearable technology, wireless channels, and other remote equipment to give low-cost healthcare monitoring. Whether put in living areas or worn on the body, network-related sensors gather detailed data to evaluate the patient's physical and mental health. The main objective of this study is to examine the current e-health monitoring system using integrated systems. Automatically providing patients with a prescription based on their status is the main goal of the e-health monitoring system. The doctor can keep an eye on the patient's health without having to communicate with them. The purpose of the study is to examine how IoT technologies are applied in the medical industry and how they help to raise the bar of healthcare delivered by healthcare institutions. The study will also include the uses of IoT in the medical area, the degree to which it is used to enhance conventional practices in various health fields, and the degree to which IoT may raise the standard of healthcare services. The main contributions in this paper are as follows: (1) importing signals from wearable devices, extracting signals from non-signals, performing peak enhancement; (2) processing and analyzing the incoming signals; (3) proposing a new stress monitoring algorithm (SMA) using wearable sensors; (4) comparing between various ML algorithms; (5) the proposed stress monitoring algorithm (SMA) is composed of four main phases: (a) data acquisition phase, (b) data and signal processing phase, (c) prediction phase, and (d) model performance evaluation phase; and (6) grid search is used to find the optimal values for hyperparameters of SVM (C and gamma). From the findings, it is shown that random forest is best suited for this classification, with decision tree and XGBoost following closely behind.
Factors influencing the reliability of intraoperative testing in deep brain stimulation for Parkinson’s disease
Authors: Mederer Tobias , Deuter Daniel , Bründl Elisabeth , Forras Patricia , Schmidt Nils Ole , Kohl Zacharias , Schlaier Jürgen 
Published: June 2023

Abstract
Background
Several meta-analyses comparing the outcome of awake versus asleep deep brain stimulation procedures could not reveal significant differences concerning the postoperative improvement of motor symptoms. Only rarely information on the procedural details is provided for awake operations and how often somnolence and disorientation occurred, which might hamper the reliability of intraoperative clinical testing. The aim of our study was to investigate possible influencing factors on the occurrence of somnolence and disorientation in awake DBS procedures.

Methods
We retrospectively analyzed 122 patients with Parkinson's disease having received implantation of a DBS system at our centre. Correlation analyses were performed for the duration of disease prior to surgery, number of microelectrode trajectories, AC-PC-coordinates of the planned target, UPDRS-scores, intraoperative application of sedative drugs, duration of the surgical procedure, perioperative application of apomorphine, and the preoperative L-DOPA equivalence dosage with the occurrence of intraoperative somnolence and disorientation.

Results
Patients with intraoperative somnolence were significantly older (p=0.039). Increased duration of the DBS procedure (p=0.020), delayed start of the surgery (p=0.049), higher number of MER trajectories (p=0.041), and the patients’ % UPDRS improvement (p=0.046) also correlated with the incidence of intraoperative somnolence. We identified the main contributing factor to intraoperative somnolence as the use of sedative drugs applied during skin incision and burr hole trepanation (p=0.019). Perioperatively applied apomorphine could reduce the occurrence of somnolent phases during the operation (p=0.026).

Conclusion
Several influencing factors were found to seemingly increase the risk of intraoperative somnolence and disorientation, while the use of sedative drugs seems to be the main contributing factor. We argue that awake DBS procedures should omit the use of sedatives for best clinical outcome. When reporting on awake DBS surgery these factors should be considered and adjusted for, to permit reliable interpretation and comparison of DBS study results.
Image embedding for denoising generative models
Authors: Asperti Andrea , Evangelista Davide , Marro Samuele , Merizzi Fabio 
Published: June 2023

AbstractDenoising Diffusion models are gaining increasing popularity in the field of generative modeling for several reasons, including the simple and stable training, the excellent generative quality, and the solid probabilistic foundation. In this article, we address the problem of embedding an image into the latent space of Denoising Diffusion Models, that is finding a suitable “noisy” image whose denoising results in the original image. We particularly focus on Denoising Diffusion Implicit Models due to the deterministic nature of their reverse diffusion process. As a side result of our investigation, we gain a deeper insight into the structure of the latent space of diffusion models, opening interesting perspectives on its exploration, the definition of semantic trajectories, and the manipulation/conditioning of encodings for editing purposes. A particularly interesting property highlighted by our research, which is also characteristic of this class of generative models, is the independence of the latent representation from the networks implementing the reverse diffusion process. In other words, a common seed passed to different networks (each trained on the same dataset), eventually results in identical images.
Randomised Controlled Trial of a Brief, Low Intensity Parenting Intervention to Promote Healthy Living: The Lifestyle Triple P Seminar Series
Authors: Bartlett J. A. , Sanders Matthew R. , Tellegen Cassandra L. , Leong Gary M. 
Published: June 2023

AbstractParents play a key role in establishing a healthy home environment. This randomised controlled trial examined the efficacy of a low-intensity parenting intervention (three 2-hour Lifestyle Triple P-Positive Parenting Program Seminars) for parents who are concerned about or interested in learning more about healthy lifestyle behaviours for children. Parents of 160 children aged 3–10 years were randomly assigned to the intervention or control condition. Primary outcomes of parenting practices, child lifestyle-specific and general behaviour and parent self-efficacy were assessed via parent self-report. Secondary outcomes included child BMI z-score, a food diary measuring energy intake, physical activity levels measured by accelerometers and parent reported time spent on screen-based activities. Assessment occurred at pre-intervention, post-intervention, and 6- and 12-months after completion. At 12-months post-intervention, intent-to-treat analyses found a significant intervention effect on overall ineffective parenting, lifestyle-specific and general parenting confidence. Child lifestyle problem behaviours reduced, with no effects on general child behaviour. On the secondary exploratory outcomes, time spent watching television reduced with no other significant effects detected. Parents viewed the intervention as high-quality and acceptable. A brief parenting program aiming to promote healthy lifestyles for all families offers promise for improving parenting skills and child lifestyle behaviour.
Quantifying pulse oximeter accuracy during hypoxemia and severe anemia using an in vitro circulation system
Authors: Gylys Raymond , Feiner John , Pologe Jonas , Delianides Theodore , Sutter Stephanie , Bickler Philip , Lipnick Michael S. 
Published: June 2023

AbstractAnemia and hypoxemia are common clinical conditions that are difficult to study and may impact pulse oximeter performance. Utilizing an in vitro circulation system, we studied performance of three pulse oximeters during hypoxemia and severe anemia. Three oximeters including one benchtop, one handheld, and one fingertip device were selected to reflect a range of cost and device types. Human blood was diluted to generate four hematocrit levels (40%, 30%, 20%, and 10%). Oxygen and nitrogen were bubbled through the blood to generate a range of oxygen saturations (O2Hb) and the blood was cycled through the in vitro circulation system. Pulse oximeter saturations (SpO2) were paired with simultaneously-measured O2Hb readings from a reference CO-oximeter. Data for each hematocrit level and each device were least-squares fit to a 2nd-order equation with quality of each curve fit evaluated using standard error of the estimate. Bias and average root mean square error were calculated after correcting for the calibration difference between human and in vitro circulation system calibration. The benchtop oximeter maintained good accuracy at all but the most extreme level of anemia. The handheld device was not as accurate as the benchtop, and inaccuracies increased at lower hematocrit levels. The fingertip device was the least accurate of the three oximeters. Pulse oximeter performance is impacted by severe anemia in vitro. The use of in vitro calibration systems may play an important role in augmenting in vivo performance studies evaluating pulse oximeter performance in challenging conditions.
The lure of the big city: smaller Danish rookeries are increasingly associated with urban land cover
Authors: Heldbjerg Henning , Pedersen Claus Lunde , Therkildsen Ole R. , Bregnballe Thomas , Ettrup Henning , Kahlert Johnny , Vikstrøm Thomas , Fox Anthony D. 
Published: June 2023

AbstractRooks Corvus frugilegus are common and widespread in urban and agricultural habitats in Denmark. Large numbers are killed annually by derogation shooting to control population growth to reduce noise near populated areas and prevent agricultural damage. Responding to increasing public complaints about noise nuisance from urban rookeries, we investigated changes in extent of urban and agricultural habitats within 500 m, 1000 m and 2000 m of all known breeding rook colonies (rookeries) in eastern Jutland, Denmark in 1991 compared to 2021 based on open access land cover GIS layers in 1990 and 2019. Numbers of rookeries increased by 40% from 95 (1991) to 133 (2021) but nest abundance increased only by 6% from 10,299 to 10,887 due to more and significantly smaller rookeries, increasingly associated with urban sites. In both years, the proportion of urban area within distance classes of rookeries was significantly higher, and the area of agriculture significantly lower, than at randomly chosen points in the same region. The proportion of urban area around each rookery decreased with increasing distance, whereas the proportion of agricultural land cover increased. The proportional area of urban land use within the distance classes increased between 1991 and 2021 whereas agricultural land cover decreased. Given no simultaneous major change in overall land use, our results indicate an increasing selection by rooks for smaller urban rookeries over agricultural landscapes, where rookeries have declined. We consider these trends, especially the proliferation of smaller rookeries in urban areas, as a potential explanation for the upsurge in public complaints about rookery noise in residential areas. We urge further research to explain the causes behind these trends before we can provide science-based solutions to resolve such conflicts effectively.
Evaluation of Larger Test Portion Sizes for Escherichia coli Shiga Toxin Producer (STEC) on the Detection by Immunomagnetic Separation and Real-Time PCR in Meat and Vegetables
Authors: Bouvier M. , Canizares M. , Hamadou B. , Guenser M. , Sergentet D. Thevenot 
Published: June 2023

AbstractThe aims of this study were (i) to evaluate the performance of the Assurance® GDS method combining immunomagnetic separation and real-time PCR for STEC detection in pooled samples (up to 375g) of vegetables and meat, and (ii) to compare its performances to that of the reference method ISO/TS-13136:2012 (25 g sample size) in artificially contaminated samples. The alternative Assurance® GDS method includes enrichment in proprietary broth at 41.5°C for 10 h followed by primary screening of TOP 7 STEC containing eae, stx genes and O157:H7 markers using MPX-Top 7 (IMS+PCR), secondary screening for serogroup identification using MPX-ID/EHEC-ID (IMS+PCR). And finally, cultural confirmation from same IMS beads on two selective agars is set up. For reference method, the enrichment was performed in BPW at 41.5°C for 18 h. A total of 120 samples of meat and vegetables, including 20 uninoculated and 100 samples spiked with stressed cells (<12 CFU/25 or 375g) of STEC, were analyzed using both methods. Our results showed that the Assurance® GDS method LOD50 ranged from 0.12 CFU/375 to 0.522 CFU/375 g and the LOD95 from 0.518 CFU/375 to 2.257 CFU/375 g. These data are similar to the LOD50 data of the reference method.
Lysobacter changpingensis sp. nov., a novel species of the genus Lysobacter isolated from a rhizosphere soil of strawberry in China
Authors: Niu Bang-Yan , Ren Dong-Jun , Zhang Fang-Bo , Zhu Hong-Tu , Wei Hai-Lei , Ma Ming-Chao , Gao Miao 
Published: June 2023

AbstractIn the present work, we characterized in detail strain CM-3-T8T, which was isolated from the rhizosphere soil of strawberries in Beijing, China, in order to elucidate its taxonomic position. Cells of strain CM-3-T8T were Gram-negative, non-spore-forming, aerobic, short rod. Growth occurred at 25–37 °C, pH 5.0–10.0, and in the presence of 0–8% (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CM-3-T8T formed a stable clade with Lysobacter soli DCY21T and Lysobacter panacisoli CJ29T, with the 16S rRNA gene sequence similarities of 98.91% and 98.50%. The average nucleotide identity and digital DNA-DNA hybridization values between strain SG-8 T and the two reference type strains listed above were 76.3%, 79.6%, and 34.3%, 27%, respectively. The DNA G + C content was 68.4% (mol/mol). The major cellular fatty acids were comprised of C15:0 iso (36.15%), C17:0 iso (8.40%), and C11:0 iso 3OH (8.28%). The major quinone system was ubiquinone Q-8. The major polar lipids were phosphatidylethanolamine (PE), phosphatidylethanolamine (PME), diphosphatidylglycerol (DPG), and aminophospholipid (APL). On the basis of phenotypic, genotypic, and phylogenetic evidence, strain CM-3-T8T (= ACCC 61714 T = JCM 34576 T) represents a new species within the genus Lysobacter, for which the name Lysobacter changpingensis sp. nov. is proposed.
New insights on Teotihuacan color technology: a proposal of a technological style for mural painting
Authors: López-Puértolas Carlos , Casanova-González Edgar , Mitrani Alejandro , Ruvalcaba-Sil José Luis 
Published: June 2023

AbstractTeotihuacan, the main city of the Classic period in Central Mexico (ca. 150/200–650 CE), was among many things, a colorful city. Through its application on mural painting, ceramics, lapidary, bone, textiles, and the human body itself, coloring materials gave meaning to the Teotihuacan reality. This research presents color as a socio-technological phenomenon from the archaeology of color, the anthropology of technology, and the application of the concept of technological style.From this scope, pictorial palettes of mural painting fragments from three Teotihuacan architectural compounds were studied by digital microscopy, colorimetry, fiber optic reflectance spectroscopy (FORS), X-ray fluorescence (XRF), Raman spectroscopy, infrared spectroscopy (FTIR), and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) in order to identify the color technology of pigments. This approach led us to identify materials shared by the three studied compounds, red and yellow earths, cinnabar, malachite, pseudomalachite, azurite, and the Teotihuacan grayish blue, found to contain a mix of bone black with calcite. Our results contribute to the discussion on the use of raw materials and their mixtures. We observed a standardization of pigment technology in Teotihuacan mural painting through the use of shared and standard formulations with four indicators that we propose as markers of a technological style for pigments, along with variations in the color materials that evidence the use of different strategies for the procurement and distribution of raw materials among the diverse architectural assemblages of the city.
Tetrandrine citrate suppresses lung adenocarcinoma growth via SLC7A11/GPX4-mediated ferroptosis
Authors: Mo Xiaocong , Hu Di , Yuan Kaisheng , Luo Juyu , Huang Cheng , Xu Meng 
Published: June 2023

AbstractFerroptosis is a mode of programmed cell death that plays a crucial role in tumor biology processes. Although tetrandrine citrate (TetC) has been demonstrated to exert anti-tumor effects, it is still unclear whether TetC inhibits lung adenocarcinoma (LUAD) progression by inducing ferroptosis. The study showcased the inhibitory effect of TetC on the viability and progression of tumor cells, including intracellular iron overload, accumulation of reactive oxygen species (ROS), over-expression of malondial-dehyde (MDA), and depletion of glutathione (GSH). Notably, TetC-induced cell death was clearly reversed by three different ferroptosis-related inhibitors. TetC also induced changes in the mitochondrial morphology of LUAD cells, similar to those observed in typical ferroptosis. Further analysis through Western blot (WB) and Immunofluorescence (IF) assays identified that TetC inhibited the expression and fluorescence intensity of both solute carrier family 7 (SLC7A11) and glutathione peroxidase-4 (GPX4). More importantly, over-expression of SLC7A11 could rescue the TetC-induced ferroptosis. Finally, in our vivo experiment, we discovered that TetC significantly slowed the growth rate of subcutaneous transplanted A549 cells, ultimately proving to be biosafe. In conclusion, our study first identified the mechanism by which TetC-induced ferroptosis in LUAD via SLC7A11/GPX4 signaling.