bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between hair cortisol and blood pressure: a systematic review and meta-analysis
Authors: Pageau Lauren M. , Ng Teresa J. , Ling Jiying , Given Barbara A. , Robbins Lorraine B. , Deka Pallav , Schlegel Emma C. 
Published: April 2023

Objective:
Stress is widely considered to be a risk factor for high blood pressure (BP), but evidence on the associations between biomarkers of chronic stress and BP is inconsistent. This systematic review and meta-analysis assessed the current state of the science on relationships between measures of cortisol concentration reflecting chronic stress exposure [hair cortisol concentration (HCC), nail cortisol concentration)] and BP.

Methods:
PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Cochrane Library, and Embase were searched. Random effects models were used to assess the pooled effect size. Exploratory moderation analysis was performed.

Results:
Out of 32 465 identified, 16 articles met eligibility criteria and were included in the review, while 14 were included in the meta-analysis. No articles were reported on the association between nail cortisol concentration and BP. Small, positive associations were observed between HCC and SBP [r = 0.19 (95% confidence interval (CI): 0.08–0.29)] and HCC and DBP [r = 0.13 (95% CI: 0.04–0.22)]. Cortisol analysis method was identified as a significant moderator of the association between HCC and DBP. HCC was largely, positively associated with hypertension status [odds ratio = 3.23 (95% CI: 2.55–4.09), P < 0.001].

Conclusions:
Current evidence suggests that higher HCC may be associated with elevated BP and a potential risk factor for hypertension. However, results should be interpreted with caution because HCC can be affected by hair color, hair care products, and analytic methods. Given the limitations of studies included in this review, further research is needed.
Direct oral anticoagulant adsorption and laboratory detection of lupus anticoagulant
Authors: Novelli Chiara , Pradella Paola , Papandrea Maria , Montaruli Barbara 
Published: April 2023

Direct oral anticoagulants (DOACs) interfere with many coagulation assays, mostly in lupus anticoagulant (LA) detection, causing false positive and negative results. Despite guidelines recommendations, LA testing may be important during anticoagulation when the clinician has to decide whether to prolong or discontinue the drug.

Objectives
In this study, the effect of activated charcoal (DOAC-Stop, DS) as a DOAC-adsorbent was investigated on samples from DOACs treated and untreated patients.

Basic methods
165 plasma samples with a LA request were collected in three laboratories: 105 were from patients receiving DOACs and 60 were from nonanticoagulated patients with 30 LA negative and 30 LA positive. All coagulation screening assays and LA assays were evaluated before and after DS treatment.

Results
The adsorption technique reduced DOACs concentration below the Lower Limit of Quantification. For nonanticoagulated patients: no significant difference in ratio results of coagulation screening (prothrombin time, activated partial thromboplastin time and thrombin time) and LA tests were observed before and after addition of DS in LA positive and negative patients. Every LA was correctly classified. For anticoagulated patients: a statistically significant difference was found for coagulation screening assays and LA assays. Final LA conclusions changed after DS addition from positive to negative in 58.9% of patients (more frequently with Rivaroxaban) and from negative to positive in 8% of patients (more frequently with Apixaban).

Conclusions
Our study suggests that DOAC-Stop can be used in daily laboratory practice to remove DOACs interference for a more accurate assessment of LA that is essential for diagnosis and management of APS patients.
Brief Report: Prevalence and Predictors of Concern About Anal Cancer Among Sexual and Gender Minorites Living With HIV in Abuja, Nigeria
Authors: Chama John , Adebiyi Ruxton , Volpi Connor , Ononaku Uche , Maigida John , Aka Abayomi , Katu Christiana , Shutt Ashley , Charurat Man , Adebajo Sylvia , Nowak Rebecca G. 
Published: April 2023

Background:
Anal cancer rates are rising among sexual and gender minorities (SGM) who live with HIV and engage in anal sex. Given that secondary cancer prevention programs for nonanal cancers are underutilized in sub-Saharan Africa, our objective was to assess concerns for anal cancer and hesitancy with cancer prevention among at-risk Nigerian SGM.

Methods:
Within 4 weeks, SGM living with HIV were surveyed on levels of worry and hesitancy in engaging with a future anal cancer screening and treatment study. Worry was measured on a 5-point Likert scale (0%, 25%, 50%, 75%, 100%) and categorized as low ≤25%, moderate 50%, and high ≥75%. Ordinal logistic regression identified factors associated with worry by estimating unadjusted and adjusted odds ratios (aOR) and 95% confidence intervals (95% CI).

Results:
Of 800 enrolled SGM, median age was 32 (interquartile range: 25–38) years, 99.2% were on antiretroviral therapy, of which 78.5% reported ≥95% pill adherence. The prevalence of moderate and high worry was 46.9% and 39.5%, respectively. Increasing worry was associated with reporting as a bottom for sexual position (aOR: 3.12; 95% CI: 2.04 to 4.80), top or bottom for sexual position (aOR: 2.94; 95% CI: 1.92 to 4.52), or knowing anyone with anal cancer (aOR: 2.99; 95% CI: 1.36 to 6.57). Participants aged ≥35 years were less worried (aOR: 0.72; 95% CI: 0.59 to 0.95). Ninety-nine percent of participants provided contact information for a future cancer prevention study.

Discussion:
SGM who heard about and engaged in at-risk practices for anal cancer were willing to access secondary prevention. Addressing biopsychosocial factors such as age could foster future engagement.
Internal Thoracic Vein Tumor Thrombus From Sternal Melanoma Metastasis on 18F-FDG PET/CT
Authors: Ensle Falko , Schaab Jan A. , Dimitriou Florentia , Huellner Martin W. , Maurer Alexander 
Published: April 2023

Abstract
We present 18F-FDG PET/CT findings of an internal thoracic vein tumor thrombus from melanoma in a 76-year-old woman. Restaging 18F-FDG PET/CT shows a progressive disease with an internal thoracic vein tumor thrombus from a sternal bone metastasis. Although cutaneous malignant melanoma may metastasize to any body part, a direct tumor invasion of veins and the formation of a tumor thrombus represent an extremely rare complication.
Incidental Meningioma With Altered PSMA Expression After Systemic Hormone Therapy and Local Radiotherapy Detected by 68Ga-PSMA PET/CT
Authors: Tamer Fatih , Omur Ozgur 
Published: April 2023

Abstract
A 59-year-old man underwent radical prostatectomy for adenocarcinoma in 2009. Because of the progression of PSA levels, a 68Ga-PSMA PET/CT scan was performed in January 2020. A suspicious uptake was detected in the left cerebellar hemisphere, and there was no evidence of distant metastatic disease other than recurrent malignancy in the prostatectomy bed. MRI revealed a meningioma located in the left cerebellopontine angle. Although PSMA uptake of the lesion increased in the first imaging after hormone therapy, partial regression was noted after radiotherapy applied to this region.
HEMOPERFUSION USING THE LPS-SELECTIVE MESOPOROUS POLYMERIC ADSORBENT IN SEPTIC SHOCK: A MULTICENTER RANDOMIZED CLINICAL TRIAL
Authors: Rey Sergei , Kulabukhov Vladimir M. , Popov Alexander , Nikitina Olga , Berdnikov Gennady , Magomedov Marat , Kim Timur , Masolitin Sergei , Ignatenko Olga , Krotenko Nikolai , Marysheva Anastasia , Chaus Nikolai , Ohinko Leonid , Mendibaev Makarii , Chumachenko Anastasia , Pisarev Vladimir 
Published: April 2023

ABSTRACT
Extracorporeal hemoperfusion (EHP) may improve the course and outcomes of patients with septic shock by targeting cytokines or bacterial endotoxins (lipopolysaccharide [LPS]). Here, we present the results of a multicenter randomized controlled trial (clinicaltrials.gov/ct2/show/NCT04827407) to assess the efficiency and safety of Efferon LPS hemoperfusion cartridges engineered for multimodal targeting LPS, host-derived cytokine, and damage-associated molecule pattern molecules. Patients with intra-abdominal sepsis (IAS) and septic shock (Sepsis-3) were subjected to EHP procedures (n = 38). Control patients with IAS and septic shock (n = 20) were treated using conventional protocols without EHP. The primary end point was resolution of septic shock. Secondary end points included MAP, vasopressor drug dose, partial pressure of arterial oxygen/fraction of inspired oxygen ratio, Sequential Organ Failure Assessment score, length of stay in the intensive care unit, and satisfaction with device use by a 5-point Likert scale. Clinical laboratory tests for a blood cells count, lactate and creatinine concentration, nephelometry test for C-reactive protein, immunochemiluminescent test for procalcitonin, and immunoenzyme analysis for IL-6 concentration were used to monitor the EHP effect versus the control group. Data were analyzed followed the intention-to-treat approach. Wilcoxon STATA 16.0 (StataCorp, College Station, TX) and Excel 2019 with XLStat 2019 add-in (Addinsoft, Paris, France) were used for statistical analysis of the results. The Fine and Gray method of competing risks was used to analyze the primary end point and other data representing the time to event. EHP resulted in a significant and rapid increase in MAP and partial pressure arterial oxygen/fraction of inspired oxygen ratio, progressive decline in norepinephrine doses, and multiorgan deficiency, as evaluated by Sequential Organ Failure Assessment scores. Importantly, EHP led to significantly rapid cumulative mechanical ventilation weaning compared with the control group (subdistribution hazard ratio, 2.5; P = 0.037). Early 3-day mortality was significantly reduced in the Efferon LPS versus control group; however, no significant improvements in survival in 14 and 28 days were revealed. Laboratory tests showed rapidly decreased levels of LPS, procalcitonin, C-reactive protein, IL-6, creatinine, leukocytes, and neutrophils only in the Efferon LPS group. Results demonstrate that EHP with Efferon LPS is a safe procedure to abrogate septic shock and normalize clinical and pathogenically relevant biomarkers in patients with IAS.
Early VTE prophylaxis in severe traumatic brain injury: A propensity score weighted EAST multicenter study
Authors: Ratnasekera Asanthi M. , Kim Daniel , Seng Sirivan S. , Jacovides Christina , Kaufman Elinore J. , Sadek Hannah M. , Perea Lindsey L. , Monaco Christina , Shnaydman Ilya , Lee Alexandra Jeongyoon , Sharp Victoria , Miciura Angela , Trevizo Eric , Rosenthal Martin , Lottenberg Lawrence , Zhao William , Keininger Alicia , Hunt Michele , Cull John , Balentine Chassidy , Egodage Tanya , Mohamed Aleem , Kincaid Michelle , Doris Stephanie , Cotterman Robert , Seegert Sara , Jacobson Lewis E. , Williams Jamie , Whitmill Melissa , Palmer Brandi , Mentzer Caleb , Tackett Nichole , Hranjec Tjasa , Dougherty Thomas , Morrissey Shawna , Donatelli-Seyler Lauren , Rushing Amy , Tatebe Leah C. , Nevill Tiffany J. , Aboutanos Michel B. , Hamilton David , Redmond Diane , Cullinane Daniel C. , Falank Carolyne , McMellen Mark , Duran Christ , Daniels Jennifer , Ballow Shana , Schuster Kevin , Ferrada Paula 
Published: April 2023

BACKGROUND
Patients with traumatic brain injury (TBI) are at high risk of venous thromboembolism events (VTE). We hypothesized that early chemical VTE prophylaxis initiation (≤24 hours of a stable head CT) in severe TBI would reduce VTE without increasing risk of intracranial hemorrhage expansion (ICHE).

METHODS
A retrospective review of adult patients 18 years or older with isolated severe TBI (Abbreviated Injury Scale score, ≥ 3) who were admitted to 24 Level I and Level II trauma centers from January 1, 2014 to December 31 2020 was conducted. Patients were divided into those who did not receive any VTE prophylaxis (NO VTEP), who received VTE prophylaxis ≤24 hours after stable head CT (VTEP ≤24) and who received VTE prophylaxis >24 hours after stable head CT (VTEP>24). Primary outcomes were VTE and ICHE. Covariate balancing propensity score weighting was utilized to balance demographic and clinical characteristics across three groups. Weighted univariate logistic regression models were estimated for VTE and ICHE with patient group as predictor of interest.

RESULTS
Of 3,936 patients, 1,784 met inclusion criteria. Incidences of VTE was significantly higher in the VTEP>24 group, with higher incidences of DVT in the group. Higher incidences of ICHE were observed in the VTEP≤24 and VTEP>24 groups. After propensity score weighting, there was a higher risk of VTE in patients in VTEP >24 compared with those in VTEP≤24 (odds ratio, 1.51; 95% confidence interval, 0.69–3.30; p = 0.307), however was not significant. Although, the No VTEP group had decreased odds of having ICHE compared with VTEP≤24 (odds ratio, 0.75; 95% confidence interval, 0.55–1.02, p = 0.070), the result was not statistically significant.

CONCLUSION
In this large multi-center analysis, there were no significant differences in VTE based on timing of initiation of VTE prophylaxis. Patients who never received VTE prophylaxis had decreased odds of ICHE. Further evaluation of VTE prophylaxis in larger randomized studies will be necessary for definitive conclusions.

LEVEL OF EVIDENCE
Therapeutic Care Management; Level III.
Exchange rates, bond yields and the stock market: nonlinear evidence of Indonesia during the COVID-19 period
Authors: Prananta Billy , Alexiou Constantinos 
Published: April 2023

PurposeThe authors explore the relationship between the exchange rate, bond yield and the stock market as well as the effect of capital market dynamics on the exchange rate before and during the COVID-19 pandemic.Design/methodology/approachThe authors employ a non-linear autoregressive distributed lag (NARDL) methodology using daily data of the Indonesian economy over the period 2012–2021.FindingsWhilst, over the full sample period, the authors find no cointegration between the exchange rate, the 10-year bond yield and stock market, for the COVID-19 period, evidence of cointegration is present. Furthermore, the results suggest that asymmetric effects are evident both in the short as well as the long run.Originality/valueTo the best of the authors’ knowledge, this is the first time that the relationship between the exchange rate, bond yield and the stock market as well as the effect of capital market dynamics on the exchange rate before and during the COVID-19 pandemic has been explored in the case of the Indonesian economy.
Assessing business process models: a literature review on techniques for BPMN testing and formal verification
Authors: Lopes Tomás , Guerreiro Sérgio 
Published: April 2023

PurposeTesting business processes is crucial to assess the compliance of business process models with requirements. Automating this task optimizes testing efforts and reduces human error while also providing improvement insights for the business process modeling activity. The primary purposes of this paper are to conduct a literature review of Business Process Model and Notation (BPMN) testing and formal verification and to propose the Business Process Evaluation and Research Framework for Enhancement and Continuous Testing (bPERFECT) framework, which aims to guide business process testing (BPT) research and implementation. Secondary objectives include (1) eliciting the existing types of testing, (2) evaluating their impact on efficiency and (3) assessing the formal verification techniques that complement testing.Design/methodology/approachThe methodology used is based on Kitchenham's (2004) original procedures for conducting systematic literature reviews.FindingsResults of this study indicate that three distinct business process model testing types can be found in the literature: black/gray-box, regression and integration. Testing and verification approaches differ in aspects such as awareness of test data, coverage criteria and auxiliary representations used. However, most solutions pose notable hindrances, such as BPMN element limitations, that lead to limited practicality.Research limitations/implicationsThe databases selected in the review protocol may have excluded relevant studies on this topic. More databases and gray literature could also be considered for inclusion in this review.Originality/valueThree main originality aspects are identified in this study as follows: (1) the classification of process model testing types, (2) the future trends foreseen for BPMN model testing and verification and (3) the bPERFECT framework for testing business processes.
Key residential construction defects: a framework for their identification and correlated causes
Authors: Lambers Rebeca , Lamari Fiona , Skitmore Martin , Rajendra Darmicka 
Published: April 2023

Purpose
Construction defects are one of the primary causes of deficient quality performance and constantly yield project cost and schedule overruns mostly because of rework. This study aims to propose a new method for identifying a bespoke checklist of the most recurrent defects in residential construction work and their correlated causes as a basis for developing a framework for practical improvements in managing defect risks.

Design/methodology/approach
A literature review was first used to ground the defects within the existing theory and develop a new framework for ranking the key defects involved. This was demonstrated and tested by an analysis of Queensland Building Construction Commission (QBCC) archival data for 42,000 reported defects in new Queensland residential buildings. A questionnaire survey of 427 construction practitioners from 37 trades was then conducted to determine their causes.

Findings
The developed framework consists of preconditions for defective acts, defective supervision and organizational influences and is found to be suitable for analyzing the QBCC archives to rank the 20 most frequent defects. In the demonstration study, a questionnaire survey identified the highest frequency latent causes of defective acts to be workers taking shortcuts to complete tasks, workers’ lack of skill or knowledge level, challenges and limitations of technical constructability, and incorrect material supply; the failure to correct a known problem and poor supervision for defective supervision; and inadequate employee training, low managerial priority for quality and high time pressure and constraints for organizational influences.

Originality/value
The method is a new approach to identifying the key defects in residential construction work and their correlated causes for developing bespoke checklists as an aid to in managing defect risks.
Development paths of people’s sustainable livelihood based on climate change: a case study of Yunnan minority areas
Authors: Wu Jiaxin , Liu Lei , Yang Hongjuan 
Published: April 2023

Purpose
This study aims to evaluate the characteristics of climate change in Yunnan minority areas and identify an effective path to promote sustainable livelihoods based on climate change.

Design/methodology/approach
Taking Yunnan Province as an example, based on the expansion of the traditional sustainable livelihood framework, the authors constructed a system dynamics (SD) model of sustainable livelihood from the six subsystems of natural, physical, financial, social, human and cultural and tested the accuracy and effectiveness of the model with data from Cangyuan County. By adjusting these parameters, five development paths are designed to simulate the future situation of the livelihood system and determine the optimal path.

Findings
Climate change has exacerbated the vulnerability of people’s livelihoods. In future, each of the five development paths will be advantageous for promoting sustainable livelihoods. However, compared with Path I (maintaining the status quo), Path III (path of giving priority to culture) and Path IV (path of giving priority to economic development) have more obvious advantages. Path II (path of giving priority to people’s lives) gradually increases the development rate by promoting people’s endogenous motivation, and Path V (path of coordinated development) is better than the other paths because of its more balanced consideration.

Originality/value
The analytical framework of sustainable livelihoods based on the characteristics of minority areas is broadened. By constructing a SD model of the livelihood system, the limitations of traditional static analysis have been overcome and a development path for promoting sustainable livelihoods through simulation is proposed. This study offers a theoretical framework and reference method for livelihood research against the backdrop of climate change and a decision-making basis for enhancing climate adaptability and realizing sustainable livelihoods.
Advancing research on project management in hybrid organizations: insights from the social enterprise literature
Authors: Jewer Jennifer , Jugdev Kam , Amini Mohammad Farshad 
Published: April 2023

PurposeThis paper aims to understand the challenges of managing projects in hybrid organizations. The authors explore how organizations with persistent competing institutional logics strive to balance competing priorities, and the authors craft a research agenda to examine the capabilities to manage projects in hybrid organizations.Design/methodology/approachThe authors focus on the social enterprise hybrid organizational form to study how such organizations manage persistent competing social and economic logics. The authors review the project management and social enterprise literature to generate new insights and suggest future research directions for theory development for project management.FindingsThe understanding of the influences of the institutional context on the management of projects is still quite limited. The authors propose that project managers need adaptive capabilities to address how the dual logics, and their corresponding different expectations, can be flexibly combined. The objective is not to reduce the complexity due to the different logics, which is the focus of much of the literature on institutional complexity. Instead, the focus is on how to incorporate dual logics into a successfully blended hybrid organization.Originality/valueThere is a dearth of literature about how projects are successfully managed in hybrid organizations with persistent competing institutional logics, like social enterprises, and important questions remain to be answered. This paper offers new insights on the capabilities required to flexibly combine dual logics that would generally compete and create conflict on projects in hybrid organizations.