bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of models in predicting residual disease in ovarian cancer: comparing CT urography with PET/CT
Authors: Lin Lingling , Liu Qing , Cheng Jiejun , Wang Tingting , Zhou Yan , Song Mengfan , Zhou Bin 
Published: April 2023

Background Many ovarian cancer (OC) residual-disease prediction models were not externally validated after being constructed, the clinical applicability needs to be evaluated. Purpose To compare computed tomography urography (CTU) with PET/CT in validating models for predicting residual disease in OC. Material and Methods A total of 250 patients were included during 2018–2021. The CTU and PET/CT scans were analyzed, generating CT-Suidan, PET-Suidan, CT-Peking Union Medical College Hospital (PUMC), and PET-PUMC models. All imagings were evaluated by two readers independently, then compared to pathology. According to surgical outcomes, all patients were divided into the R0 group, with no visible residual disease, and the R1 group, with any visible residual disease. Logistic regression was used to assess the discrimination and calibration abilities of each model. Results CTU and PET/CT showed good diagnostic performance in predicting OC peritoneal metastases based on the Suidan and PUMC model (all the accuracies >0.8). As for model evaluation, the value of correct classification of the CT-Suidan, PET-Suidan, CT-PUMC, and PET-PUMC models was 0.89, 0.84, 0.88, and 0.83, respectively, representing stable calibration. The areas under the curve (AUC) of these models were 0.95, 0.90, 0.91, and 0.90, respectively. Furthermore, the accuracy of these models at the optimal threshold value (score 3) was 0.75, 0.78, 0.80, and 0.80, respectively. All two-paired comparisons of the AUCs and accuracies did not show a significant difference (all P > 0.05). Conclusion CT-Suidan, CT-PUMC, PET-Suidan, and PET-PUMC models had equal abilities in predicting the residual disease of OC. The CT-PUMC model was recommended for its economic and user-friendly characteristics.
New daily persistent headache: A systematic review and meta-analysis
Authors: Cheema Sanjay , Mehta Dwij , Ray Jason Charles , Hutton Elspeth J , Matharu Manjit Singh 
Published: April 2023

Objective To perform a systematic review and meta-analysis of the epidemiology, precipitants, phenotype, comorbidities, pathophysiology, treatment, and prognosis of primary new daily persistent headache. Methods We searched PubMed/Medline, EMBASE, Cochrane, and clinicaltrials.gov until 31 December 2022. We included original research studies with any design with at least five participants with new daily persistent headache. We assessed risk of bias using National Institutes of Health Quality Assessment Tools. We used random-effects meta-analysis where suitable to calculate pooled estimates of proportions. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis compliant study is registered with PROSPERO (registration number CRD42022383561). Results Forty-six studies met inclusion criteria, predominantly case series, including 2155 patients. In 67% (95% CI 57–77) of cases new daily persistent headache has a chronic migraine phenotype, however new daily persistent headache has been found to be less likely than chronic migraine to be associated with a family history of headache, have fewer associated migrainous symptoms, be less vulnerable to medication overuse, and respond less well to injectable and neuromodulatory treatments. Conclusions New daily persistent headache is a well described, recognisable disorder, which requires further research into its pathophysiology and treatment. There is a lack of high-quality evidence and, until this exists, we recommend continuing to consider new daily persistent headache a distinct disorder.
Polypropylene based bio-composites for packaging materials: Physico-mechanical impacts of prepared hyper-branched polyamidoamine and gamma-irradiation
Authors: Fathy ES , Ibrahim Saber , Elnaggar Mona Y , Fahmy Hager , Lotfy Salah 
Published: April 2023

In an attempt to produce bio-composites that possess good physico-mechanical properties, polyamidoamine (PAMAM) was synthesized and characterized as a multi-nitrogen terminal biocompatible and nontoxic polymeric species. It was mixed at various ratios of 1.0, 2.0, and 3.0% with polypropylene (PP) via Brabender-like apparatus. The prepared bio-composites were exposed to 20 kGy of gamma-irradiation to investigate the influence of ionizing radiation on the fabricated specimens. Parameters of mechanical for instance tensile strength (TS), modulus of elasticity (EM), elongation at break (%), and hardness (Shore D), of bio-composites, were considered. Moreover, the stress-strain curves of the fabricated samples were investigated. Furthermore, FTIR and thermal analysis including TGA and DSC have been investigated. The crystallinity % of all investigated samples was calculated on the basis of DSC measurements. Overall migration of prepared samples has been performed as an applicable study of food packaging. FTIR results revealed the disappearance of the absorption peak at 1730 cm−l of the carbonyl group of polyamidoamine after the formation of PP/PAMAM bio-composites, indicating a successful combination of the PP matrix with polyamidoamine. The incorporation of PAMAM resulted in a steady improvement of the melting temperature (Tm) of the native PP. The thermal stability of PP/PAMAM composition increases with increasing PAMAM and after being exposed to 20 kGy irradiation. Mechanical data revealed that TS of PP increased with PAMAM content up to 3.0%. The development in TS increased from 20 MPa of native PP to 45 MPa of PP/2% PAMAM bio-composites suggesting the superior interaction between the synthetic PAMAM and PP texture. Furthermore, the prepared bio-composite films displayed highly acceptable migration limits.
In-person versus virtual administration of the American College of Rheumatology gold standard cognitive battery in systemic lupus erythematosus: Are they interchangeable?
Authors: Barraclough ML , Diaz-Martinez JP , Knight A , Bingham K , Su J , Kakvan M , Grajales C Muñoz , Tartaglia MC , Ruttan L , Wither J , Choi MY , Bonilla D , Anderson N , Appenzeller S , Parker B , Katz P , Beaton D , Green R , Bruce IN , Touma Z 
Published: April 2023

Objective During the COVID-19 pandemic, many research studies were adapted, including our longitudinal study examining cognitive impairment (CI) in systemic lupus erythematosus (SLE). Cognitive testing was switched from in-person to virtual. This analysis aimed to determine if the administration method (in-person vs. virtual) of the ACR-neuropsychological battery (ACR-NB) affected participant cognitive performance and classification. Methods Data from our multi-visit, SLE CI study included demographic, clinical, and psychiatric characteristics, and the modified ACR-NB. Three analyses were undertaken for cognitive performance: (1) all visits, (2) non-CI group visits only and (3) intra-individual comparisons. A retrospective preferences questionnaire was given to participants who completed the ACR-NB both in-person and virtually. Results We analysed 328 SLE participants who had 801 visits (696 in-person and 105 virtual). Demographic, clinical, and psychiatric characteristics were comparable except for ethnicity, anxiety and disease-related damage. Across all three comparisons, six tests were consistently statistically significantly different. CI classification changed in 11/71 (15%) participants. 45% of participants preferred the virtual administration method and 33% preferred in-person. Conclusions Of the 19 tests in the ACR-NB, we identified one or more problems with eight (42%) tests when moving from in-person to virtual administration. As the use of virtual cognitive testing will likely increase, these issues need to be addressed – potentially by validating a virtual version of the ACR-NB. Until then, caution must be taken when directly comparing virtual to in-person test results. If future studies use a mixed administration approach, this should be accounted for during analysis.
Improved and computationally stable estimation of relative risk regression with one binary exposure
Authors: Pozza Francesco , Kenne Pagui Euloge Clovis , Salvan Alessandra 
Published: April 2023

In medical statistics, when the effect of a binary risk factor on a binary response is of interest, relative risk is often the preferred measure due to its direct interpretation. However, statistical inference on this quantity is not as straightforward as for other measures of association, especially when further explanatory variables have to be taken into account. Starting from a review of available methods for inference on relative risk, this paper deals with small and moderate sample size settings for which we show that classical approaches can be problematic. For this reason, we propose the use of improved estimation procedures, aiming at mean or median bias reduction of the maximum likelihood estimator. In particular, these methods are developed for a new alternative specification of a model recently proposed by Richardson et al, where higher computational stability of the estimation methods is achieved. A real-data example and extensive simulation studies show that the proposed methods perform remarkably better than the standard ones.
Nerolidol Attenuates Diabetic Embryopathy in Streptozotocin-induced Diabetic Pregnant Rats by Reducing Embryonic and Maternal Oxidative Stress
Authors: Li Jingjing , Aiyasamy Kalaivani 
Published: April 2023

Background Pregnancy complicated by diabetes leads to congenital disorders, spontaneous abortion, and neonatal morbidity and mortality, which are termed diabetic embryopathy or fetopathy. Objectives In this work, we planned to investigate the therapeutic potentials of nerolidol against streptozotocin (STZ)-induced diabetic embryopathy in rats through attenuating maternal and fetal oxidative stress. Materials and Methods The male and female Wistar rats were allowed to mate for a night at a 1:1 ratio. After the confirmation of pregnancy, the rats were administered 40 mg/kg of STZ (i.p.) to initiate diabetes and treated with 20 and 40 mg/kg of nerolidol. The changes in food intake, body weight, blood glucose, and urine output were regularly monitored. The levels of lipid profiles were estimated using assay kits. The oxidative stress and antioxidant biomarkers in the liver tissues and embryonic fractions were measured using assay kits. Results The nerolidol treatment considerably depleted the blood glucose and urine output and augmented the body weight and diet intake in diabetic rats. The nerolidol suppressed the cholesterol (Ch), triglycerides (TG), and very low density lipoprotein (VLDL) and elevated the high density lipoprotein (HDL) level in diabetic pregnant rats. The maternal and embryonic oxidative stress levels are effectively reduced by the nerolidol treatment by decreasing the malondialdehyde (MDA) and reactive oxygen species (ROS) levels. The levels of antioxidants were also increased by the nerolidol on both liver and embryonic fractions of diabetic pregnant rats. Conclusion Our results exhibited that the nerolidol treatment considerably reduced embryonic and maternal oxidative stress and embryonic deaths. Hence, it can be a hopeful therapeutic candidate to treat diabetic embryopathy.
GEDEFO-SEFH management of antineoplastic extravasations survey results
Authors: Jiménez-Pulido Inmaculada , Albert-Marí María Asunción , Conde-Estévez David , San José-Ruiz Begoña , Gil-Lemus María Ángeles , Cercós-LLetí Ana Cristina , Esteban-Mensua María Jesús , Díaz-Carrasco María Sacramento 
Published: April 2023

Introduction Extravasation is a potentially severe complication of intravenous administration of antineoplastic drugs. The limited data makes it difficult to develop an optimal management scheme. The objective of this study is to describe the clinical practice in the extravasation management of antineoplastic agents in Spanish centers. Methods An online survey was distributed to oncology pharmacists using the email distribution list of the Spanish Society of Hospital Pharmacists. Respondents were surveyed on the standard operational protocol (SOP) of extravasation, tissue damage risk classification, and specific measures of extravasation management. Results A total of 68 surveys were completed. A specific extravasation SOP was available in 82.4% centers. The pharmacist participates in the authorship (100%) and actively collaborates in extravasation management (76.5%). A tissue damage risk classification based on the three categories was mostly adopted (48.2%) and 73.2% applied specific criteria based on concentration and/or extravasated volume. Extravasation management was mainly performed with the application of physical measures and/or antidotes (91.2%). High variability in the choices of pharmacological and/or physical measures recommended is outstanding. Conclusion The results of this study highlight the involvement of Spanish pharmacists in extravasation management, the application of physical measures and/or pharmacological measures as the method of choice in extravasation management, as well as the existing discrepancies in tissue damage risk classification and management recommendations
Perfectionism, Goal Orientation, and Emerging Adults’ Identity Processing Styles
Authors: Rice Kenneth G. , Lopez Frederick G. , Wang Qianyi 
Published: April 2023

The current study explored the direct and interactive contributions of multidimensional measures of perfectionism and goal orientation in predicting patterns of identity-related self-processing for pre-COVID-19 and during-COVID-19 samples of traditional age (18–22 year old) emerging adult college students ( N = 722). Regression models controlled for age, binary gender, and race, then tested the unique conditional effects and interactions between perfectionism and goal orientation in explaining variability in each of three identity processing styles. After controlling for multiple covariates and hypothesis tests, only a few effects were repeated between the two samples. Those results indicated that a growth-seeking goal orientation was predictive of an informational identity style whereas validation-seeking goal orientation was a significant predictor of diffuse-avoidant and normative identity processing styles. The overall findings suggested that fruitful targets for future intervention studies promoting healthy identity development during the college years might include reducing validation-seeking while strengthening growth-seeking motives.
Nurses Transitioning to Primary Health Care in Australia: A Practice Improvement Initiative
Authors: Cox Rebekah , Robinson Tracy , Rossiter Rachel , Collison Lisa , Hills Danny 
Published: April 2023

Introduction Current nursing programs provide little pre-registration information and clinical exposure to primary health care nursing practice. Newly graduated nurses and those transitioning to primary health care report disorientation and confusion. Limited knowledge about the ideal elements of a program to support transitioning nurses is an imperative to understand how best to support nurses during this period. The peak body for nurses in primary health care was funded to develop and implement a 1-year transition to practice improvement initiative for nurses in Australia about to be employed in or who are new to primary health care. This quality improvement evaluation study aimed to determine the impact of the transition program on participants’ nursing knowledge, skills, and confidence, and their overall satisfaction with the program. Methods A mixed methods evaluation of the project utilized data from online pre- and post-participation surveys, mentor meetings, and field notes. Descriptive statistics and paired t-tests were employed for quantitative items. Free text and field notes were subject to broad thematic analysis. Findings from qualitative and quantitative data were triangulated. Results Ninety-three nurse participants and 62 mentors were recruited. There were statistically significant differences between mean summed post-completion and pre-completion self-assessment rating scores for knowledge, skills, and confidence. Program elements were well received. The orientation workshop, mentoring, and education activities were identified as most influential in supporting transition. The self-assessment framework was identified as least influential. Conclusion A 12-month transition program was effective in building the knowledge, skills, and confidence of participants to deliver comprehensive and effective nursing services.
Investigation of mechanical properties and elucidation of factors affecting wood-based structural panels under embedment stress with a circular dowel i: analysis of the influence of various conditions on the embedment properties
Authors: Sudo Ryutaro , Aoki Kenji , Inayama Masahiro 
Published: April 2023

AbstractEmbedment properties are vital to timber structural designs, and many types of wood-based structural panels have been developed for diverse uses. Comprehensive and systematic studies regarding the embedment properties of wood-based structural panels are limited. In this study, a jig that allows the observation of fracture processes is developed, and a monotonic tensile embedment test is conducted on plywood, oriented strandboard (both strong and weak axes), particleboard, medium density fiberboard, and hardboard. The parameters used in the test are the dowel diameter, pilot hole size, and end and edge distances. The effects of these parameters on the embedment properties (i.e., the failure mode, ductility, maximum stress, and yield stress) are discussed comprehensively. The failure mode is determined by the edge distance. At a sufficient edge distance, ductile failure occurs, and the load is maintained until the remaining end distance reaches a certain value. The maximum stress and yield stress are analyzed quantitatively via standardized multiple regression analysis. The results suggest the following: (i) The ratio of the in-plane strength to the internal bond strength is related to the failure behavior; (ii) the dowel diameter, fiber direction, and load levels affect the stress spread pattern of the embedment pressure.
Comparative genomic analysis of two ST320 Streptococcus pneumoniae isolates, representing serotypes 19A and 19F
Authors: Puzia Weronika , Gawor Jan , Gromadka Robert , Skoczyńska Anna , Sadowy Ewa 
Published: April 2023

Abstract
Background
Streptococcus pneumoniae (pneumococcus) represents an important human pathogen, responsible for respiratory and invasive infections in the community. The efficacy of polysaccharide conjugate vaccines formulated against pneumococci is reduced by the phenomenon of serotype replacement in population of this pathogen. The aim of the current study was to obtain and compare complete genomic sequences of two pneumococcal isolates, both belonging to ST320 but differing by the serotype.

Results
Here, we report genomic sequences of two isolates of important human pathogen, S. pneumoniae. Genomic sequencing resulted in complete sequences of chromosomes of both isolates, 2,069,241 bp and 2,103,144 bp in size, and confirmed the presence of cps loci specific for serotypes 19A and 19F. The comparative analysis of these genomes revealed several instances of recombination, which involved not only S. pneumoniae but also presumably other streptococci as donors.

Conclusions
We report the complete genomic sequences of two S. pneumoniae isolates of ST320 and serotypes 19A and 19F. The detailed comparative analysis of these genomes revealed the history of several recombination events, clustered in the region including the cps locus.
Integrated metabolomics and transcriptomics analysis during seed germination of waxy corn under low temperature stress
Authors: Jiang Feng , Lv Shishi , Zhang Zili , Chen Qingchun , Mai Jiaqi , Wan Xiaorong , Liu Pengfei 
Published: April 2023

AbstractBackgroundWaxy corn has a short growth cycle and high multiple cropping index. However, after being planted in early spring, late autumn and winter, it is susceptible to low temperature (LT), which reduces the emergence rate and yield. Therefore, it is important to analyze the response mechanism of waxy corn under LT stress.ResultsAll phenotype indexes of waxy corn inbred lines N28 were significantly higher than waxy corn inbred lines N67 under LT. With the increase of LT stress time, all physiological indexes showed an upward trend in N28 and N67. Differentially expressed genes (DEGs) 16,017 and 14,435 were identified in N28 and N67 compared with nongerminated control under LT germination, respectively, and differential metabolites 127 and 93 were detected in N28 and N67, respectively. In addition, the expression level of some genes involved in plant hormones and mitogen activated protein kinase (MAPK) signaling pathways was significantly up-regulated in N28. Compared with N67, flavonoid metabolites were also significantly enriched in N28 under LT germination.ConclusionUnder LT stress, the inbred lines N28 was significantly higher than the inbred lines N67 in the phenotypic and physiological indices of cold resistance. Compared with N67, the expression levels of some genes involved in the plant hormones and MAPK pathways were significantly up-regulated in N28, and flavonoid metabolites were also significantly enriched in N28 under LT stress. These genes and metabolites may help N28 to improve cold resistance and may be as potential target genes for cold resistance breeding in waxy corn.
Metabolomics based on GC-MS revealed hub metabolites of pecan seeds germinating at different temperatures
Authors: Xue Tingting , Liu Sian , Liu Jia , Yuan Yingdan 
Published: April 2023

AbstractBackgroundAs an important plant source of food and edible oils, pecans are rich in metabolites. Few studies have focused on metabolites involved in pecan seed germination at different temperatures.ResultsIn our study, we germinated pecan seeds at different temperatures and found that, the germination rate and water content were highest at 30°C. It was found that the radicle of pecan seeds could sense seed coat cracking by observing the microstructure and cell ultra-structure of the seeds at the early stage of germination. We compared the metabolomes of seeds at different temperatures with different germination processes. A total of 349 metabolites were identified, including 138 primary metabolites and 211 secondary metabolites. KEGG enrichment analysis indicated that the differential metabolites were mainly enriched in the metabolic pathways, amino acid synthesis pathways and ABC transporters. Using weighted gene co-expression network analysis (WGCNA), three modules of closely related metabolites were identified. In the brown module, most of hub metabolites were amino substances, whereas in the blue module, many hub metabolites were sugars.ConclusionsAmino acids and carbohydrates play an important role in pecan seed germination. Differential metaboliteanalysis showed that 30°C was the temperature at which metabolites differed most significantly. This study provides useful information for further research on the seedling establishment of pecan seeds.