bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Should Risk and Ambiguity Affect Our Charitable Giving?
Authors: Buchak Lara 
Published: May 2023

AbstractSuppose we want to do the most good we can with a particular sum of money, but we cannot be certain of the consequences of different ways of making use of it. This article explores how our attitudes towards risk and ambiguity bear on what we should do. It shows that risk-avoidance and ambiguity-aversion can each provide good reason to divide our money between various charitable organizations rather than to give it all to the most promising one. It also shows how different attitudes towards risk and ambiguity affect whether we should give to an organization which does a small amount of good for certain or to one which does a large amount of good with some small or unknown probability.
The mental health of all children in contact with social services: a population-wide record-linkage study in Northern Ireland
Authors: McKenna Sarah , O’Reilly Dermot , Maguire Aideen 
Published: May 2023

Abstract

Aims
Children in contact with social services are at high risk for mental ill health, but it is not known what proportion of the child population has contact with social services or how risk varies within this group compared to unexposed peers. We aim to quantify the extent and nature of contact with social services within the child population in Northern Ireland (NI) and the association with mental ill health. We also examine which social care experiences identify those most at risk.

Methods
This is a population-based record-linkage study of 497,269 children (aged under 18 years) alive and resident in NI in 2015 using routinely collected health and social care data. Exposure was categorized as (1) no contact, (2) referred but assessed as not in need (NIN), (3) child in need (CIN) and (4) child in care (CIC). Multilevel logistic regression analyses estimated odds ratios (ORs) for mental ill health indicated by receipt of psychotropic medication (antidepressants, anxiolytics, antipsychotics and hypnotics), psychiatric hospital admission and hospital-presenting self-harm or ideation.

Results
Over one in six children (17.2%, n = 85,792) were currently or previously in contact with social services, and almost one child in every 20 (4.8%, n = 23,975) had contact in 2015. Likelihood of any mental ill health outcome increased incrementally with the level of contact with social services relative to unexposed peers: NIN (OR 5.90 [95% confidence interval (CI) 5.10–6.83]), CIN (OR 5.99 [95% CI 5.50–6.53]) and CIC (OR 12.60 [95% CI 10.63–14.95]). All tiers of contact, number of referrals, number of care episodes and placement type were strongly associated with the likelihood of mental ill health.

Conclusion
Children who have contact with social services account for a large and disproportionate amount of mental ill health in the child population. Likelihood of poor mental health across indicators is highest in care experienced children but also extends to the much larger population of children in contact with social services but never in care. Findings suggest a need for targeted mental health screening and enhanced support for all children in contact with social services.
Spatial Accessibility Evaluation and Location Optimization of Primary Healthcare in China: A Case Study of Shenzhen
Authors: Chen Liutong , Zeng Huatang , Wu Liqun , Tian Qiannan , Zhang Ning , He Rongxin , Xue Hao , Zheng Junyao , Liu Jinlin , Liang Fengchao , Zhu Bin 
Published: May 2023

AbstractThe unbalanced allocation of healthcare resources is a major challenge that hinders access to healthcare. Taking Shenzhen as an example, this study aimed to enhance equity in obtaining healthcare services, through measuring and visualizing the spatial accessibility of community healthcare centers (CHC), and optimizing CHC geospatial allocation. We used the number of health technicians per 10,000 to represent the CHC's service capacity, combined with resident points and census data to calculate the population the CHC needs to carry, and then analyzed the accessibility based on the Gaussian two‐step floating catchment area method. In 2020, five regions in Shenzhen had better spatial accessibility scores: Nanshan (0.250), Luohu (0.246), Futian (0.244), Dapeng (0.226), and Yantian (0.196). The spatial accessibility of CHCs shows a gradual decrease from the city center to the edge, which is affected by economic and topographic factors. With the support of the maximal covering location problem model, we selected up to 567 candidate locations for the new CHC, which could improve Shenzhen's accessibility score from 0.189 to 0.361 and increase the coverage population by 63.46% within a 15‐min impedance. By introducing spatial techniques and maps, this study provides (a) new evidence for promoting equitable access to primary healthcare services in Shenzhen and (b) a foundation for improving the accessibility of public service facilities in other areas.
Subgrid Parameterization of Eddy, Meanfield and Topographic Interactions in Simulations of an Idealized Antarctic Circumpolar Current
Authors: Kitsios V. , Frederiksen J. S. , O’Kane T. J. 
Published: May 2023

AbstractThe ocean circulation dynamics can be represented as a high‐dimensional multi‐scale nonlinear system with inhomogenous meanfields and topography. Numerical simulations of the ocean dynamics resolve the large scales of motion on a computational grid, with the unresolved subgrid interactions parameterized. These simulations are highly dependent upon the grid resolution, unless the subgrid terms are appropriately parameterized. There are five fundamental classes of subgrid interactions: eddy‐eddy; eddy‐topographic; eddy‐meanfield; meanfield‐meanfield; and meanfield‐topographic. Scale dependent parameterizations representing each of these interaction classes are presented here in oceanic flows for the first time. Subgrid parameterizations are calculated and validated in baroclinic quasi‐geostrophic simulations of idealized Antarctic Circumpolar Current flows with representative mean currents and ocean floor topography. The parameterization coefficients are derived from the coarse grained statistics of high resolution reference simulations in spectral space. Stochastic and deterministic parameterizations are developed for the eddy‐eddy interactions, and deterministic forms for the remaining classes. The kinetic energy spectra and meanfield resulting from large eddy simulations (LES) adopting these coefficients accurately replicate those of the reference simulation. The eddy‐eddy interactions are dominant, but all classes need to be parameterized for best results. For LES where baroclinic instability is explicitly resolved the stochastic variants out‐perform the deterministic ones across all scales. When baroclinic instability is not explicitly resolved, the stochastic variants out‐perform the deterministic cases at the large scales, but introduce some distortions at the smallest resolved scales. This study provides an assessment of the relevant strengths of the subgrid interaction classes in an idealized yet representative ocean.
Earthquake Magnitude With DAS: A Transferable Data‐Based Scaling Relation
Authors: Yin Jiuxun , Zhu Weiqiang , Li Jiaxuan , Biondi Ettore , Miao Yaolin , Spica Zack J. , Viens Loïc , Shinohara Masanao , Ide Satoshi , Mochizuki Kimihiro , Husker Allen L. , Zhan Zhongwen 
Published: May 2023

AbstractDistributed Acoustic Sensing (DAS) is a promising technique to improve the rapid detection and characterization of earthquakes. Previous DAS studies mainly focus on the phase information but less on the amplitude information. In this study, we compile earthquake data from two DAS arrays in California, USA, and one submarine array in Sanriku, Japan. We develop a data‐driven method to obtain the first scaling relation between DAS amplitude and earthquake magnitude. Our results reveal that the earthquake amplitudes recorded by DAS in different regions follow a similar scaling relation. The scaling relation can provide a rapid earthquake magnitude estimation and effectively avoid uncertainties caused by the conversion to ground motions. Our results show that the scaling relation appears transferable to new regions with calibrations. The scaling relation highlights the great potential of DAS in earthquake source characterization and early warning.
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK
Authors: Wei Jia , Matthews Philippa C. , Stoesser Nicole , Newton John N. , Diamond Ian , Studley Ruth , Taylor Nick , Bell John I. , Farrar Jeremy , Kolenchery Jaison , Marsden Brian D. , Hoosdally Sarah , Jones E. Yvonne , Stuart David I. , Crook Derrick W. , Peto Tim E. A. , Walker A. Sarah , Pouwels Koen B. , Eyre David W. ,   the COVID-19 Infection Survey team, Thomas Tina , Ayoubkhani Daniel , Black Russell , Felton Antonio , Crees Megan , Jones Joel , Lloyd Lina , Sutherland Esther , Pritchard Emma , Vihta Karina-Doris , Doherty George , Kavanagh James , Chau Kevin K. , Hatch Stephanie B. , Ebner Daniel , Ferreira Lucas Martins , Christott Thomas , Dejnirattisai Wanwisa , Mongkolsapaya Juthathip , Cameron Sarah , Tamblin-Hopper Phoebe , Wolna Magda , Brown Rachael , Cornall Richard , Screaton Gavin , Lythgoe Katrina , Bonsall David , Golubchik Tanya , Fryer Helen , Cox Stuart , Paddon Kevin , James Tim , House Thomas , Robotham Julie , Birrell Paul , Jordan Helena , Sheppard Tim , Athey Graham , Moody Dan , Curry Leigh , Brereton Pamela , Jarvis Ian , Godsmark Anna , Morris George , Mallick Bobby , Eeles Phil , Hay Jodie , VanSteenhouse Harper , Lee Jessica , White Sean , Evans Tim , Bloemberg Lisa , Allison Katie , Pandya Anouska , Davis Sophie , Conway David I. , MacLeod Margaret , Cunningham Chris 
Published: May 2023

AbstractFollowing primary SARS-CoV-2 vaccination, whether boosters or breakthrough infections provide greater protection against SARS-CoV-2 infection is incompletely understood. Here we investigated SARS-CoV-2 antibody correlates of protection against new Omicron BA.4/5 (re-)infections and anti-spike IgG antibody trajectories after a third/booster vaccination or breakthrough infection following second vaccination in 154,149 adults ≥18 y from the United Kingdom general population. Higher antibody levels were associated with increased protection against Omicron BA.4/5 infection and breakthrough infections were associated with higher levels of protection at any given antibody level than boosters. Breakthrough infections generated similar antibody levels to boosters, and the subsequent antibody declines were slightly slower than after boosters. Together our findings show breakthrough infection provides longer-lasting protection against further infections than booster vaccinations. Our findings, considered alongside the risks of severe infection and long-term consequences of infection, have important implications for vaccine policy.
Digital mapping of surface turbulence status and aerodynamic stall on wings of a flying aircraft
Authors: Xu Zijie , Cao Leo N. Y. , Li Chengyu , Luo Yingjin , Su Erming , Wang Weizhe , Tang Wei , Yao Zhaohui , Wang Zhong Lin 
Published: May 2023

AbstractReal-time monitoring of flow turbulence is very difficult but extremely important in fluid dynamics, which plays an important role in flight safety and control. Turbulence can cause airflow to detach at the end of the wings, potentially resulting in the aerodynamic stall of aircraft and causing flight accidents. Here, we developed a lightweight and conformable system on the wing surface of aircraft for stall sensing. Quantitative data about airflow turbulence and the degree of boundary layer separation are provided in situ using conjunct signals provided by both triboelectric and piezoelectric effects. Thus, the system can visualize and directly measure the airflow detaching process on the airfoil, and senses the degree of airflow separation during and after a stall for large aircraft and unmanned aerial vehicles.
Modulation of the gut microbiome with nisin
Authors: O’Reilly Catherine , Grimaud Ghjuvan M. , Coakley Mairéad , O’Connor Paula M. , Mathur Harsh , Peterson Veronica L. , O’Donovan Ciara M. , Lawlor Peadar G. , Cotter Paul D. , Stanton Catherine , Rea Mary C. , Hill Colin , Ross R. Paul 
Published: May 2023

AbstractNisin is a broad spectrum bacteriocin used extensively as a food preservative that was identified in Lactococcus lactis nearly a century ago. We show that orally-ingested nisin survives transit through the porcine gastrointestinal tract intact (as evidenced by activity and molecular weight determination) where it impacts both the composition and functioning of the microbiota. Specifically, nisin treatment caused a reversible decrease in Gram positive bacteria, resulting in a reshaping of the Firmicutes and a corresponding relative increase in Gram negative Proteobacteria. These changes were mirrored by the modification in relative abundance of pathways involved in acetate, butyrate (decreased) and propionate (increased) synthesis which correlated with overall reductions in short chain fatty acid levels in stool. These reversible changes that occur as a result of nisin ingestion demonstrate the potential of bacteriocins like nisin to shape mammalian microbiomes and impact on the functionality of the community.
Generative and discriminative training of Boltzmann machine through quantum annealing
Authors: Srivastava Siddhartha , Sundararaghavan Veera 
Published: May 2023

AbstractA hybrid quantum-classical method for learning Boltzmann machines (BM) for a generative and discriminative task is presented. BM are undirected graphs with a network of visible and hidden nodes where the former is used as the reading site. In contrast, the latter is used to manipulate visible states’ probability. In Generative BM, the samples of visible data imitate the probability distribution of a given data set. In contrast, the visible sites of discriminative BM are treated as Input/Output (I/O) reading sites where the conditional probability of output state is optimized for a given set of input states. The cost function for learning BM is defined as a weighted sum of Kullback-Leibler (KL) divergence and Negative conditional Log-likelihood (NCLL), adjusted using a hyper-parameter. Here, the KL Divergence is the cost for generative learning, and NCLL is the cost for discriminative learning. A Stochastic Newton-Raphson optimization scheme is presented. The gradients and the Hessians are approximated using direct samples of BM obtained through quantum annealing. Quantum annealers are hardware representing the physics of the Ising model that operates on low but finite temperatures. This temperature affects the probability distribution of the BM; however, its value is unknown. Previous efforts have focused on estimating this unknown temperature through regression of theoretical Boltzmann energies of sampled states with the probability of states sampled by the actual hardware. These approaches assume that the control parameter change does not affect the system temperature; however, this is usually untrue. Instead of using energies, the probability distribution of samples is employed to estimate the optimal parameter set, ensuring that the optimal set can be obtained from a single set of samples. The KL divergence and NCLL are optimized for the system temperature, and the result is used to rescale the control parameter set. The performance of this approach, as tested against the theoretically expected distributions, shows promising results for Boltzmann training on quantum annealers.
Lithium carbonate accelerates the healing of apical periodontitis
Authors: Kagioka Takumi , Itoh Shousaku , Hue Mai Thi , Abe Makoto , Hayashi Mikako 
Published: May 2023

AbstractApical periodontitis is a disease caused by bacterial invasions through the root canals. Our previous study reported that lithium chloride (LiCl) had a healing effect on apical periodontitis. The aim of this report is to investigate the healing properties and mechanism of lithium ion (Li+) for apical periodontitis using rat root canal treatment model. 10-week-old male Wistar rat’s mandibular first molars with experimentally induced apical periodontitis underwent root canal treatment and were applied lithium carbonate (Li2CO3) containing intracanal medicament. Base material of the medicament was used as a control. Subject teeth were scanned by micro-CT every week and the periapical lesion volume was evaluated. The lesion volume of Li2CO3 group was significantly smaller than that of the control group. Histological analysis showed that in Li2CO3 group, M2 macrophages and regulatory T cells were induced in the periapical lesion. In situ hybridization experiments revealed a greater expression of Col1a1 in Li2CO3 group compared with the control group. At 24 h after application of intracanal medicament, Axin2-positive cells were distributed in Li2CO3 group. In conclusion, Li2CO3 stimulates Wnt/β-catenin signaling pathway and accelerate the healing process of apical periodontitis, modulating the immune system and the bone metabolism.
A retrospective analysis of clinical features of patients hospitalized with SARS-CoV-2 Omicron variants BA.1 and BA.2
Authors: Groza Cristina , Totschnig David , Wenisch Christoph , Atamaniuk Johanna , Zoufaly Alexander 
Published: May 2023

AbstractThe causative agent of the ongoing Corona virus disease 2019 (COVID-19) pandemic, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has acquired a considerable amount of mutations, leading to changes in clinical manifestations and increased transmission. Recent studies based on animal disease models and data from the general population were reporting a higher pathogenicity of the BA.2 sublineage compared to BA.1. The aim of this study was to provide real world data on patients with the SARS-CoV-2 Omicron BA.1 and BA.2 subvariants treated at our center, highlighting similarities and differences in the clinical disease course. We retrospectively collected and analyzed the data of adult patients admitted with confirmed SARS-CoV-2 infection at the Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria. Patient characteristics including age, underlying diseases, vaccination status and outcome were compared between patients with the BA.1 and BA.2 subvariants. Between January 2022 and May 2022 we included 168 patients infected with Omicron BA.1 and 100 patients with BA.2. Patients admitted with BA.2 were significantly older, more often fully immunized and required less dexamethasone than patients with BA.1. No substantial differences were identified between patients infected with BA.1 and BA.2 regarding BMI, laboratory findings, need for supplemental oxygen, mortality and other evaluated comorbidities excepting active malignancies. The significantly larger percentage of fully immunized patients admitted with BA.2 is pointing to an increased transmissibility of this subvariant, while the comparable outcome of a somewhat older and sicker patient population might be indicative of reduced virulence.
Potential effect of chloroquine and propranolol combination to treat colorectal and triple-negative breast cancers
Authors: Anselmino L. E. , Baglioni M. V. , Reynoso G. , Rozados V. R. , Scharovsky O. G. , Rico M. J. , Menacho-Márquez M. 
Published: May 2023

AbstractDrug repositioning explores the reuse of non-cancer drugs to treat tumors. In this work, we evaluated the effect of the combination of chloroquine and propranolol on colorectal and triple-negative breast cancers. Using as in vitro models the colorectal cancer cell lines HCT116, HT29, and CT26, and as triple-negative breast cancer models the 4T1, M-406, and MDA-MB-231 cell lines, we evaluated the effect of the drugs combination on the viability, apoptosis, clonogenicity, and cellular migratory capacity. To explore the in vivo effects of the combination on tumor growth and metastasis development we employed graft models in BALB/c, nude, and CBi mice. In vitro studies showed that combined treatment decreased cell viability in a dose-dependent manner and increased apoptosis. Also, we demonstrated that these drugs act synergically and that it affects clonogenicity and migration. In vivo studies indicated that this drug combination was effective on colorectal models but only partially on breast cancer. These results contributed to the search for new and safe treatments for colorectal and triple-negative carcinomas.
Quaternization of high molecular weight chitosan for increasing intestinal drug absorption using Caco-2 cells as an in vitro intestinal model
Authors: Wongwanakul Ratjika , Aueviriyavit Sasitorn , Furihata Tomomi , Gonil Pattarapond , Sajomsang Warayuth , Maniratanachote Rawiwan , Jianmongkol Suree 
Published: May 2023

AbstractPotential use of a quaternized chitosan (MW 600 kDa) with 65% of 3-chloro-2-hydroxypropyltrimethylammonium (600-HPTChC65) as an absorptive enhancer was investigated in Caco-2 monolayers. 600-HPTChC65 (0.005% w/v) quickly reduced transepithelial electrical resistance (TEER) to the maximum level in 40 min with full recovery within 6 h after removal. Its TEER reduction was corresponded to increased FD4 transport across the monolayers and disrupted localization of tight junction proteins ZO-1 and occludin at the cell borders. 600-HPTChC65 was densely localized at the membrane surface and intercellular junctions. This chitosan (0.08–0.32% w/v) reduced the efflux ratio of [3H]-digoxin by 1.7- 2 folds, suggesting an increased [3H]-digoxin transport across the monolayers. Its binding with P-gp on Caco-2 monolayer increased the signal of fluorescence-labeled anti-P-gp (UIC2) reactivity due to conformational change. 600-HPTChC65 (0.32% w/v) had no effect on P-gp expression in the Caco-2 monolayers. These results suggest that 600-HPTChC65 could enhance drug absorption through tight junction opening and decreased P-gp function. Its interaction with the absorptive barrier mainly resulted in disrupting ZO-1 and occludin organization as well as changing in P-gp conformation.
Sparse identification of Lagrangian for nonlinear dynamical systems via proximal gradient method
Authors: Purnomo Adam , Hayashibe Mitsuhiro 
Published: May 2023

AbstractThe autonomous distillation of physical laws only from data is of great interest in many scientific fields. Data-driven modeling frameworks that adopt sparse regression techniques, such as sparse identification of nonlinear dynamics (SINDy) and its modifications, are developed to resolve difficulties in extracting underlying dynamics from experimental data. However, SINDy faces certain difficulties when the dynamics contain rational functions. The Lagrangian is substantially more concise than the actual equations of motion, especially for complex systems, and it does not usually contain rational functions for mechanical systems. Few proposed methods proposed to date, such as Lagrangian-SINDy we have proposed recently, can extract the true form of the Lagrangian of dynamical systems from data; however, these methods are easily affected by noise as a fact. In this study, we developed an extended version of Lagrangian-SINDy (xL-SINDy) to obtain the Lagrangian of dynamical systems from noisy measurement data. We incorporated the concept of SINDy and used the proximal gradient method to obtain sparse Lagrangian expressions. Further, we demonstrated the effectiveness of xL-SINDy against different noise levels using four mechanical systems. In addition, we compared its performance with SINDy-PI (parallel, implicit) which is a latest robust variant of SINDy that can handle implicit dynamics and rational nonlinearities. The experimental results reveal that xL-SINDy is much more robust than the existing methods for extracting the governing equations of nonlinear mechanical systems from data with noise. We believe this contribution is significant toward noise-tolerant computational method for explicit dynamics law extraction from data.