bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the ocean dynamics in a wind-jet region using high-resolution models
Authors:   , Ràfols Bundó Laura 
Published: July 2023

The water currents and the wave field at the Catalan coast (in the Northwestern Mediterranean Sea) are investigated. However, the main research is focused at the northern margin of the Ebro Shelf, where there is a relatively high amount of data for study purposes and where episodes of strong northwesterly wind occur. In such cases, the wind is channeled through the Ebro Valley and intensifies upon reaching the sea, resulting in a wind jet.

The research has been divided into four parts: (1) the study of the water circulation induced by a wind jet, by means of the Regional Ocean Modeling System (ROMS) numerical model; (2) the study of the waves dynamics induced by a wind jet, using the Simulating WAves Nearshore (SWAN) numerical model; (3) the study of the wave-current interactions during wind-jet events, coupling the numerical models used formerly; and (4) the implementation and validation of a waves and currents forecasting system at the Catalan coast, based on the knowledge gained during the research performed in the previous parts.
S'investiguen els corrents marins i l'onatge a la costa catalana (al nord-oest del Mar Mediterrani). Tanmateix, la recerca principal es centra al marge nord de la plataforma de l'Ebre, on hi ha una quantitat relativament alta de dades útils per a la investigació i on tenen lloc episodis de fort vent del nord-oest. En aquests casos, el vent és canalitzat al llarg de la vall de l'Ebre i s'intensifica quan arriba al mar, resultant en un wind jet. La investigació s'ha dividit en quatre parts: (1) l'estudi de la circulació de l'aigua induïda per un wind jet, utilitzant el model numèric Regional Ocean Modeling System (ROMS); (2) l'estudi de l'onatge induït per un wind jet, mitjançant el model numèric Simulating WAves Nearshore (SWAN); (3) l'estudi de les interaccions onatge-corrents durant episodis de wind jet, acoblant els models numèrics utilitzats anteriorment; i (4) la implementació i validació d'un sistema de predicció d'onatge i corrents a la costa catalana, basat en el coneixement adquirit durant la recerca realitzada en les parts anteriors.
School Safety and Infrastructure Compliance to Requirements of Face-To-Face Classes of the Selected Public Secondary Schools
Authors: Galgo Avelina , Curaza Lydia Josefina 
Published: July 2023

Huge differences were expected in the new normal learning, and a significant transition was needed. While the implementation of face-to-face classes was still at the infant stage, it is very important to know the challenges of the school heads so that actions can be taken in a timely fashion. The study aimed to determine the school safety and infrastructure compliance to requirements for face-to-face classes of the selected public secondary schools in Butuan City Division. A mixed-method approach was used in the study, which was considered an appropriate approach considering the nature of the data gathered and the objectives of interest. The School Safety Assessment Tool (SSAT) was used to determine the level of readiness of schools in preparation for the safe re-opening of classes, which provided the necessary information on the improvements and adjustments to be made before the implementation of face-to-face classes. An interview guide was designed to determine the experiences and practices of school principals in relation to school management during the pandemic. Strict adherence to necessary guidelines is major preparation for schools to secure permits for the full implementation of face-to-face classes. Information drive and collaboration with stakeholders increase the sustainability aspect of face-to-face implementation. Schools have taken measures to ensure the safety of children who will be attending in-person classes, such as masks and other PPE policies for teachers, school staff, and students by national and local guidelines to enhance hygiene measures and adequate handwashing facilities, frequent cleaning of surfaces and shared objects, appropriate ventilation.
High‐Density Integration of Ultrabright OLEDs on a Miniaturized Needle‐Shaped CMOS Backplane
Authors: Hillebrandt Sabina , Moon Chang‐Ki , Taal Adriaan J. , Overhauser Henry , Shepard Kenneth L. , Gather Malte C. 
Published: July 2023

AbstractDirect deposition of organic light‐emitting diodes (OLEDs) on silicon‐based complementary metal–oxide–semiconductor (CMOS) chips has enabled self‐emissive microdisplays with high resolution and fill‐factor. Emerging applications of OLEDs in augmented and virtual reality (AR/VR) displays and in biomedical applications, e.g., as brain implants for cell‐specific light delivery in optogenetics, require light intensities orders of magnitude above those found in traditional displays. Further requirements often include a microscopic device footprint, a specific shape and ultrastable passivation, e.g., to ensure biocompatibility and minimal invasiveness of OLED‐based implants. In this work, up to 1024 ultrabright, microscopic OLEDs are deposited directly on needle‐shaped CMOS chips. Transmission electron microscopy and energy‐dispersive X‐ray spectroscopy are performed on the foundry‐provided aluminum contact pads of the CMOS chips to guide a systematic optimization of the contacts. Plasma treatment and implementation of silver interlayers lead to ohmic contact conditions and thus facilitate direct vacuum deposition of orange‐ and blue‐emitting OLED stacks leading to micrometer‐sized pixels on the chips. The electronics in each needle allow each pixel to switch individually. The OLED pixels generate a mean optical power density of 0.25 mW mm−2, corresponding to >40 000 cd m−2, well above the requirement for daylight AR applications and optogenetic single‐unit activation in the brain.
Controllable Optical Features of Multiple‐Layered Axial Heterostructure Nanorods for Multicolor Polariton Nanolasers
Authors: Nam Sangwon , Lee SeungJe , Jeong Seonghyun , Ko Minji , Shim Hyeong Seop , Hong Eunha , Park Seung Min , Do Young Rag , Song Jae Kyu 
Published: July 2023

AbstractThe optical features of multiple‐layered axial heterostructures composed of III‐nitride semiconductors (GaN, InGaN, and AlGaN) are investigated to realize tunable nanolasers. The optical confinement effects develop exciton‐polariton in nanorods, leading to polariton lasing with distinctive dispersion. The lasing characteristics in the heterostructure are similar to those in the homostructure, although the carrier transfer between layers influences the optical gain. The energy‐dependent property of polariton changes the mode spacing of lasing peaks. The alloyed systems of InGaN can tune the color of lasing in the visible region, while the lasing of AlGaN is also achievable in the optimized configuration. The polarization of lasing indicates the predominant contribution of the fundamental transverse mode. Therefore, in the multiple‐layered heterostructure, controllable triple‐color lasing using the feature of polariton, modulation of band gap energy, and the amplification process of the waveguide is demonstrated for the first time, with the tunable color over a wide range of the visible region. Multicolor polariton nanolasers offer a promising path to diverse nanophotonic devices with controllable optical characteristics.
Multicomponent Reaction of Aliphatic Organozinc Reagents, Acrylates and Acyl chlorides: Synthesis of α‐Substituted β‐Ketoesters
Authors: Pinaud Marine , Baba Hamed Walid , Presset Marc , Le Gall Erwan 
Published: July 2023

AbstractAn uncatalyzed three‐component reaction employing aliphatic organozinc reagents for the preparation of α‐substituted β‐ketoesters is described. This modular procedure, which relies on a formal conjugate addition/crossed‐Claisen domino reaction between an organozinc, an acrylate and an acyl chloride, allows the straightforward synthesis of the reaction products under mild conditions. The three‐component coupling can also be conducted from alkyl iodides, in an even more simple procedure. Experimental findings account for a probable polar concerted mechanism involving at least two organozinc compounds at the stage of the transition state.
PUM1 Promotes Tumor Progression by Activating DEPTOR‐Meditated Glycolysis in Gastric Cancer
Authors: Yin Songcheng , Liu Huifang , Zhou Zhijun , Xu Xiaoyu , Wang Pengliang , Chen Wei , Deng Guofei , Wang Han , Yu Hong , Gu Liang , Huo Mingyu , Li Min , Zeng Leli , He Yulong , Zhang Changhua 
Published: July 2023

AbstractRNA‐binding proteins (RBPs) play essential roles in tumorigenesis and progression, but their functions in gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio 1 (PUM1), an RBP, induces metabolic reprogramming through post‐transcriptional regulation of DEP domain‐containing mammalian target of rapamycin (mTOR)‐interacting protein (DEPTOR) in GC. In clinical samples, elevated expression of PUM1 is associated with recurrence, metastasis, and poor survival. In vitro and in vivo experiments demonstrate that knockdown of PUM1 inhibits the proliferation and metastasis of GC cells. In addition, RNA‐sequencing and bioinformatics analyses show that PUM1 is enriched in the glycolysis gene signature. Metabolomics studies confirm that PUM1 deficiency suppresses glycolytic metabolism. Mechanistically, PUM1 binds directly to DEPTOR mRNA pumilio response element to maintain the stability of the transcript and prevent DEPTOR degradation through post‐transcriptional pathway. PUM1‐mediated DEPTOR upregulation inhibits mTORC1 and alleviates the inhibitory feedback signal transmitted from mTORC1 to PI3K under normal conditions, thus activating the PI3K–Akt signal and glycolysis continuously. Collectively, these results reveal the critical epigenetic role of PUM1 in modulating DEPTOR‐dependent GC progression. These conclusions support further clinical investigation of PUM1 inhibitors as a metabolic‐targeting treatment strategy for GC.
Poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) microcellular foams using a melt memory effect as bubble nucleation sites
Authors: Lee Jisuk , Moriyama Kenta , Hikima Yuta , Ohshima Masahiro 
Published: July 2023

AbstractPoly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) (PHBH) foams were prepared by a foam injection molding (FIM) process using nitrogen (N2) as a physical blowing agent. PHBH is a marine degradable polymer known for its heat treatment weakness. Gel permeation chromatography and rheological measurements showed that the molecular weight was reduced when the polymer was processed at a temperature higher than 160°C; however, it had a prominent melt memory of crystallization at a temperature lower than 170°C. The melt memory effect increased the crystallization temperature and provided crystal nucleation sites, which became bubble nucleation sites in the foaming process. Microcellular foams, whose cell size is smaller than 30 μm and cell density is higher than 3 × 108 cells cm−3, were prepared using the melt memory effect while suppressing the thermal decomposition by tuning the injected polymer's temperature (melting temperature) and the core‐back timing. The mechanical properties of the resulting foams were evaluated, indicating that a high ductility PHBH microcellular foam was obtained at a melting temperature of 150°C.
Structural Variations in Carboxylated Bispidine Ligands: Influence of Positional Isomerism and Rigidity on the Conformation, Stability, Inertness and Relaxivity of their Mn2+ Complexes
Authors: Ndiaye Daouda , Sy Maryame , Thor Waygen , Charbonnière Loïc J. , Nonat Aline M. , Tóth Éva 
Published: July 2023

AbstractMn2+ complexes of 2,4‐pyridyl‐disubstituted bispidine ligands have emerged as more biocompatible alternatives to Gd3+‐based MRI probes. They display relaxivities comparable to that of commercial contrast agents and high kinetic inertness, unprecedented for Mn2+ complexes. The chemical structure, in particular the substituents on the two macrocyclic nitrogens N3 and N7, are decisive for the conformation of the Mn2+ complexes, and this will in turn determine their thermodynamic, kinetic and relaxation properties. We describe the synthesis of four ligands with acetate substituents in positions N3, N7 or both. We evidence that the bispidine conformation is dependent on N3 substitution, with direct impact on the thermodynamic stability, kinetic inertness, hydration state and relaxivity of the Mn2+ complexes. These results unambiguously show that (i) solely a chair‐chair conformation allows for favorable inertness and relaxivity, and (ii) in this family such chair‐chair conformation is accessible only for ligands without N3‐appended carboxylates.
Scientific issues of zinc‐bromine flow batteries and mitigation strategies
Authors: Rana Masud , Alghamdi Norah , Peng Xiyue , Huang Yongxin , Wang Bin , Wang Lianzhou , Gentle Ian R. , Hickey Steven , Luo Bin 
Published: July 2023

AbstractZinc‐bromine flow batteries (ZBFBs) are promising candidates for the large‐scale stationary energy storage application due to their inherent scalability and flexibility, low cost, green, and environmentally friendly characteristics. ZBFBs have been commercially available for several years in both grid scale and residential energy storage applications. Nevertheless, their continued development still presents challenges associated with electrodes, separators, electrolyte, as well as their operational chemistry. Therefore, rational design of these components in ZBFBs is of utmost importance to further improve the overall device performance. In this review, the focus is on the scientific understanding of the fundamental electrochemistry and functional components of ZBFBs, with an emphasis on the technical challenges of reaction chemistry, development of functional materials, and their application in ZBFBs. Current limitations of ZBFBs with future research directions in the development of high performance ZBFBs are suggested.
Artificial intelligence in breast imaging: Current situation and clinical challenges
Authors: You Chao , Shen Yiyuan , Sun Shiyun , Zhou Jiayin , Li Jiawei , Su Guanhua , Michalopoulou Eleni , Peng Weijun , Gu Yajia , Guo Weisheng , Cao Heqi 
Published: July 2023

AbstractBreast cancer ranks among the most prevalent malignant tumours and is the primary contributor to cancer‐related deaths in women. Breast imaging is essential for screening, diagnosis, and therapeutic surveillance. With the increasing demand for precision medicine, the heterogeneous nature of breast cancer makes it necessary to deeply mine and rationally utilize the tremendous amount of breast imaging information. With the rapid advancement of computer science, artificial intelligence (AI) has been noted to have great advantages in processing and mining of image information. Therefore, a growing number of scholars have started to focus on and research the utility of AI in breast imaging. Here, an overview of breast imaging databases and recent advances in AI research are provided, the challenges and problems in this field are discussed, and then constructive advice is further provided for ongoing scientific developments from the perspective of the National Natural Science Foundation of China.
Hydrogel‐based surface‐enhanced Raman spectroscopy for food contaminant detection: A review on classification, strategies, and applications
Authors: Li Yuzhu , Yang Shixuan , Qu Cheng , Ding Zhongxiang , Liu Honglin 
Published: July 2023

AbstractToward the challenge on reliable determination of food contaminants to ensure food safety and security, surface‐enhanced Raman spectroscopy (SERS) technology with single‐molecule sensitivity through their “fingerprint” Raman signal has been developed into a fundamental and important molecular toolkit for food industry. Currently, hydrogel is attracting great interests in SERS sensing as a functional and flexible material. In this perspective, we first introduce the classification of common hydrogel and strategies for the synthesis of SERS substrates. Next, we highlight the response characteristics of hydrogel, including temperature response and pH response. Finally, we summarize the applications of hydrogel‐based substrates for food contaminant detection and discuss its developing trends and challenges. Compared to traditional solid SERS substrates, hydrogel‐based substrates have encouraging characteristics, such as unique flexibility to adhere to food surfaces for direct target molecule collection, and the stable three‐dimensional network scaffold that prevents the aggregation of SERS hot spots, etc. These advantages suggest that hydrogel‐based substrates have great potential for food safety analysis and monitoring.
Diurnal proteome profile of the mouse cerebral cortex: Conditional deletion of the Bmal1 circadian clock gene elevates astrocyte protein levels and cell abundance in the neocortex and hippocampus
Authors: Bering Tenna , Gadgaard Camilla , Vorum Henrik , Honoré Bent , Rath Martin Fredensborg 
Published: July 2023

AbstractCircadian oscillators, defined by cellular 24 h clock gene rhythms, are found throughout the brain. Cerebral cortex‐specific conditional knockout of the clock gene Bmal1 (Bmal1 CKO) leads to depressive‐like behavior, but the molecular link from clock gene to altered behavior is unknown. Further, diurnal proteomic data on the cerebral cortex are currently unavailable. With the aim of determining the diurnal proteome profile and downstream targets of the cortical circadian clock, we here performed a proteomic analysis of the mouse cerebral cortex. Proteomics identified approximately 2700 proteins in both the neocortex and the hippocampus. In the neocortex, 15 proteins were differentially expressed (>2‐fold) between day and night, mainly mitochondrial and neuronal plasticity proteins. Only three hippocampal proteins were differentially expressed, suggesting that daily protein oscillations are more prominent in the neocortex. The number of differentially expressed proteins was reduced in the Bmal1 CKO, suggesting that daily rhythms in the cerebral cortex are primarily driven by local clocks. The proteome of the Bmal1 CKO cerebral cortex was dominated by upregulated proteins expressed in astrocytes, including GFAP (4‐fold) and FABP7 (>20‐fold), in both the neocortex and hippocampus. These findings were confirmed at the transcript level. Cellular analyses of astrocyte components revealed an increased number of GFAP‐positive cells in the Bmal1 CKO cerebral cortex. Further, BMAL1 was found to be expressed in both GFAP‐ and FABP7‐positive astrocytes of control animals. Our data show that Bmal1 is required for proper cellular composition of the cerebral cortex, suggesting that increased cortical astrocyte activity may induce behavioral changes.
Natural History and Phenotypic Spectrum of GAA‐FGF14 Sporadic Late‐Onset Cerebellar Ataxia (SCA27B)
Authors: Wirth Thomas , Clément Guillemette , Delvallée Clarisse , Bonnet Céline , Bogdan Thomas , Iosif Andra , Schalk Audrey , Chanson Jean‐Baptiste , Pellerin David , Brais Bernard , Roth Virginie , Wandzel Marion , Fleury Marie‐Céline , Piton Amélie , Calmels Nadège , Namer Izzie Jacques , Kremer Stéphane , Tranchant Christine , Renaud Mathilde , Anheim Mathieu 
Published: July 2023

AbstractBackgroundHeterozygous GAA expansions in the FGF14 gene have been related to autosomal dominant cerebellar ataxia (SCA27B‐MIM:620174). Whether they represent a common cause of sporadic late‐onset cerebellar ataxia (SLOCA) remains to be established.ObjectivesTo estimate the prevalence, characterize the phenotypic spectrum, identify discriminative features, and model longitudinal progression of SCA27B in a prospective cohort of SLOCA patients.MethodsFGF14 expansions screening combined with longitudinal deep‐phenotyping in a prospective cohort of 118 SLOCA patients (onset >40 years of age, no family history of cerebellar ataxia) without a definite diagnosis.ResultsPrevalence of SCA27B was 12.7% (15/118). Higher age of onset, higher Spinocerebellar Degeneration Functional Score, presence of vertigo, diplopia, nystagmus, orthostatic hypotension absence, and sensorimotor neuropathy were significantly associated with SCA27B. Ataxia progression was ≈0.4 points per year on the Scale for Assessment and Rating of Ataxia.ConclusionsFGF14 expansion is a major cause of SLOCA. Our natural history data will inform future FGF14 clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Direct Observation of Photon Induced Giant Band Renormalization in 2D PdSe2 Dichalcogenide by Transient Absorption Spectroscopy
Authors: Chen Hualong , Kuklin Artem , Xiao Jing , Al‐Hartomy Omar A. , Al‐Ghamdi Ahmed , Wageh Swelm , Zhang Yule , Ågren Hans , Gao Lingfeng , Zhang Han 
Published: July 2023

AbstractInsight into fundamental light‐matter interaction as well as underlying photo‐physical processes is crucial for the development of novel optoelectronic devices. Palladium diselenide (PdSe2), an important representative of emerging 2D noble metal dichalcogenides, has gain considerable attention owing to its unique optical, physical, and chemical properties. In this study, 2D PdSe2 nanosheets (NSs) are prepared using the liquid‐phase exfoliation method. A broadband carrier relaxation dynamics from visible to near‐infrared bands are revealed using a time‐resolved transient absorption spectrometer, giving results that indicate band filling and bandgap renormalization (BGR) effects in the 2D PdSe2 NSs. The observed blue‐shift of the transient absorption spectra at the primary stage and the subsequent red‐shift can be ascribed to this BGR effect. These findings reveal the many‐body character of the 2D TMDs material and may hold keys for applications in the field of optoelectronics and ultrafast photonics.
Interfacial Disordering and Heterojunction Enabling Fast Proton Conduction
Authors: Yousaf Muhammad , Lu Yuzheng , Hu Enyi , Akbar Muhammad , Shah Muhammad Ali Kamran Yousaf , Noor Asma , Akhtar Majid Niaz , Mushtaq Naveed , Yan Senlin , Xia Chen , Zhu Bin 
Published: July 2023

AbstractThe interfacial disorder is a general method to change the metal‐oxygen compatibility and carrier density of heterostructure materials for ionic transport modulation. Herein, to enable high proton conduction, a semiconductor heterostructure based on spinel ZnFe2O4 (ZFO) and fluorite CeO2 is developed and investigated in terms of structural characterization, first principle calculation, and electrochemical performance. Particular attention is paid to the interfacial disordering and heterojunction effects of the material. Results show that the heterostructure induces a disordered oxygen region at the hetero‐interface of ZFO‐CeO2 by dislocating oxygen atoms, leading to fast proton transport. As a result, the ZFO‐CeO2 exhibits a high proton conductivity of 0.21 S cm−1 and promising fuel cell power output of 1070 mW cm−2 at 510 °C. Based upon these findings, a new mechanism is proposed by focusing on the change of O–O bond length to interpret the diffusion and acceleration of protons in ZFO‐CeO2 on the basis of the Grotthuss mechanism. This study provides a new strategy to customize semiconductor heterostructure to enable fast proton conduction.