bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electronic health literacy and its association with lifestyle behavior among undergraduate students: A cross-sectional survey
Authors: Shudayfat Tamadur , Hani Salam Bani , Shdaifat Emad , Al-Mugheed Khalid , Alsenany Samira Ahmed , Farghaly Abdelaliem Sally Mohammed 
Published: July 2023

Background This study aims to assess healthy lifestyle behaviors among undergraduate students and determine the association between electronic health literacy with lifestyle behavior among undergraduate Jordanian university students. Methods A descriptive cross-sectional design was used. The study recruited 404 participants utilizing undergraduate students from public and private universities. The e-Health literacy scale was used to assess the level of health information literacy among university students. Results Data were collected from 404 participants who reported very good health status, the majority of the participants were female 57.2% with an average age of 19.3 years. The results showed that participants had good health behavior in terms of exercise, taking breakfast, smoking status, and sleeping status. The results have shown an inadequate level of e-Health literacy 16.61 (SD = 4.10) out of 40. The vast majority of students, in terms of their attitudes toward the Internet, thought that Internet health information was very useful/useful (95.8%). Also, they thought that online health information was very important /important (97.3%). The results showed that students who were attending public universities had higher e-Health literacy scores rather than those who were attending private universities, t (402) = 1.81, p = .014. The mean e-Health literacy score for nonmedical students was higher than those for medical students ( p = .022). Conclusion The study's findings provide important insights into the health behaviors and electronic health literacy of undergraduate students in Jordanian universities, and offer valuable guidance for future health education programs and policies aimed at promoting healthy lifestyles in this population.
Enriching Middle School Students’ Learning Through Digital Storytelling: A Multimodal Analytical Framework
Authors: Kim (김덕순) Deoksoon , Park (박호룡) Ho-Ryong , Vorobel Oksana 
Published: July 2023

Purpose This study investigates middle school students’ learning experiences through digital storytelling, applying a multimodal analytical framework to uncover patterns in digital stories. This study explores how participants engage in pedagogical activities, reflect on their learning experiences, and articulate their voices through digital stories. Design/Approach/Methods Employing qualitative case study methods, we purposefully selected three 12-year-old female students at an urban school in the northern US. Analyses of digital stories and other data sources (interviews, classroom observations, and reflective journals) show that the students were engaged in both teaching and reflection. Findings The findings describe (1) participants and their learning experiences, (2) students’ representational and interpersonal constructs as used in their digital stories, and (3) their participation as teachers as well as learners. Originality/Value Our multimodal analytical framework illuminates how students express themselves through digital stories. Our discussion focuses on students’ learning, their identity development, the effectiveness of the analytical framework, and pedagogical implications.
Using information technology to integrate tobacco use treatment in routine oncology care: Lessons learned from the U.S. Cancer Center Cessation Initiative Cancer Centers
Authors: Bird Jennifer E. , Nguyen Claire VT , Hohl Sarah D. , D’Angelo Heather , Pauk Danielle , Adsit Robert T. , Fiore Michael , Minion Mara , McCarthy Danielle , Rolland Betsy 
Published: July 2023

Background Cancer patients who receive evidence-based tobacco-dependence treatment are more likely to quit and remain abstinent, but tobacco treatment programs (TTPs) are not consistently offered. In 2017, the U.S. National Cancer Institute, through the Cancer Moonshot, funded the Cancer Center Cessation Initiative (C3I). C3I supports 52 cancer centers to implement and expand evidence-based tobacco treatment in routine oncology care. Integration into routine care involves the use of health information technology (IT), including modifying electronic health records and clinical workflows. Here, we examine C3I cancer centers’ IT leadership involvement and experiences in tobacco-dependence treatment implementation. Method This qualitative study of C3I-funded cancer centers integrated data from online surveys and in-person, semistructured interviews with IT leaders. We calculated descriptive statistics of survey data and applied content analysis to interview transcripts. Results Themes regarding IT personnel included suggestions to involve IT early, communicate regularly, understand the roles and influence of the IT team, and match program design with IT funding and resources. Themes regarding electronic health record (EHR) modifications included beginning modifications early to account for long lead time to make changes, working with IT to identify and adapt existing EHR tools for TTP or designing tools that will support a desired workflow developed with end-users, and working with IT personnel to make sure TTPs comply with system and state policies (e.g., privacy laws). Conclusions The experiences of C3I cancer centers regarding the use of health IT to enhance tobacco-dependence treatment program implementation can guide cancer centers and community oncology practices to potentially enhance TTP implementation and patient outcomes.
Bioinformatics for wet-lab scientists: practical application in sequencing analysis
Authors: Laub Vera , Devraj Kavi , Elias Lena , Schulte Dorothea 
Published: July 2023

Abstract
Background
Genomics data is available to the scientific community after publication of research projects and can be investigated for a multitude of research questions. However, in many cases deposited data is only assessed and used for the initial publication, resulting in valuable resources not being exploited to their full depth.

Main
A likely reason for this is that many wetlab-based researchers are not formally trained to apply bioinformatic tools and may therefore assume that they lack the necessary experience to do so themselves. In this article, we present a series of freely available, predominantly web-based platforms and bioinformatic tools that can be combined in analysis pipelines to interrogate different types of next-generation sequencing data. Additionally to the presented exemplary route, we also list a number of alternative tools that can be combined in a mix-and-match fashion. We place special emphasis on tools that can be followed and used correctly without extensive prior knowledge in programming. Such analysis pipelines can be applied to existing data downloaded from the public domain or be compared to the results of own experiments.

Conclusion
Integrating transcription factor binding to chromatin (ChIP-seq) with transcriptional output (RNA-seq) and chromatin accessibility (ATAC-seq) can not only assist to form a deeper understanding of the molecular interactions underlying transcriptional regulation but will also help establishing new hypotheses and pre-testing them in silico.
Frequency and risk factors for failed weaning from supplemental oxygen therapy after general anesthesia at a postanesthesia care unit: a retrospective cohort study
Authors: Bang Yu Jeong , Park I Hyun , Jeong Heejoon 
Published: July 2023

Abstract
Background
Patients are administered supplemental oxygen upon emergence from general anesthesia against the risk of hypoxia. However, few studies have assessed the weaning from supplemental oxygen therapy. This study investigated the frequency and risk factors of failure to discontinue supplemental oxygen at a postanesthesia care unit (PACU).

Methods
This retrospective cohort study was conducted in a tertiary hospital. We reviewed the medical records of adult patients admitted to the PACU after general anesthesia for elective surgery between January 2022 and November 2022. The primary endpoint was the frequency of failed weaning from supplemental oxygen therapy at PACU. A failed weaning was defined as oxygen saturation (SpO2) < 92% after discontinuing oxygen administration. The rate of failed discontinuation of supplemental oxygen at the PACU was assessed. Demographics, intraoperative, and postoperative factors were explored to determine potential associations with failed weaning from supplemental oxygen therapy using logistic regression analysis.

Results
We analyzed 12,109 patients. We identified 842 cases of failed weaning from supplemental oxygen therapy, with a frequency of 1:14 (95% confidence interval [CI], 1:15–1:13). Risk factors that showed the strongest associations with failed weaning included postoperative hypothermia (odds ratio [OR], 5.42; 95% CI, 4.40–6.68; P < 0.001), major abdominal surgery (OR, 4.04; 95% CI, 3.29–4.99; P < 0.001), and preoperative SpO2 < 92% in room air (OR, 3.15; 95% CI, 2.09–4.64; P < 0.001).

Conclusion
In the analysis of more than 12,000 general anesthetics, an overall risk of failed weaning from supplemental oxygen therapy of 1:14 was observed. The identified risk factors may help determine the discontinuation of supplemental oxygen administration at PACU.

Trial registration
Not applicable.
Prevalence and associated factors of frailty among community dweller older adults living in Gondar town, northwest, Ethiopia: a community based cross-sectional study
Authors: Takele Mihret Dejen , Sany Kedir , Getie Kefale , Wayessa Dechasa Imiru , Jember Gashaw , Gobezie Melese , Abich Yohannes , Kibret Alemu Kassaw 
Published: July 2023

Abstract
Background
Frailty is a multidimensional geriatric condition that increases vulnerability to stressors, increases the risk of negative health outcomes, and lowers quality of life in older people. However, little attention has been paid to frailty in developing countries, particularly in Ethiopia. Therefore, the aim of the study was to investigate the prevalence of frailty syndrome and the sociodemographic, lifestyle, and clinical factors associated with it.

Methods
A community-based cross-sectional study design was conducted from April to June 2022. A total of 607 study participants were included using a single cluster sampling technique. The Tilburg frailty indicator, which is a self-reported schedule for assessment of frailty, required respondents to answer ‘yes’ or ‘no’ and the total attainable score ranged from 0 to 15. An individual with a score of ≥ 5 considered frail. Data were collected by interviewing the participants using a structured questionnaire, and the data collection tools were pre-tested before the actual data collection period to check for the accuracy of responses, language clarity, and appropriateness of the tools. Statistical analyses were performed using the binary logistic regression model.

Results
More than half of the study participants were male, and the median age of the study participants was 70, with an age range of 60–95 years. The prevalence of frailty was 39% (CI 95%, 35.51–43.1). In the final multivariate analysis model, the following factors associated with frailty were obtained: older age (AOR = 6.26 CI (3.41–11.48), presence of two or more comorbidities (AOR = 6.05 CI (3.51–10.43), activity of daily life dependency (AOR = 4.12 CI (2.49–6.80), and depression (AOR = 2.68 CI (1.55–4.63) were found to be significant factors.

Conclusion and recommendations
Our study provides epidemiological characteristics and the risk factors of frailty in the study area. Efforts to promote physical, psychological, and social health in older adults are a core objective of health policy, especially for older adults aged 80 and above years, and those with two or more comorbidities.
Self-rated physical and mental health among older adults 80 years and older: cross-sectional results from a National community sample in Thailand
Authors: Pengpid Supa , Peltzer Karl 
Published: July 2023

Abstract
Background
The aim of this study was to assess the self-reported physical health (SRPH) and self-reported mental health (SRMH) of older adults 80 years and older in Thailand.

Methods
We analyze national cross-sectional data from the Health, Aging and Retirement in Thailand (HART) in 2015. Physical and mental health status was assessed by self-report.

Results
The sample included 927 participants (excluding 101 proxy interviews), 80–117 years, median age 84 years [interquartile range (IQR) 81–86 years]. The median SRPH was 70.0 (IQR = 50.0–80.0), and median SRMH was 80.0 (IQR = 70.0 to 90.0). The prevalence of (good) SRPH was 53.3%, and the prevalence of (good) SRMH was 59.9%. In the final adjusted model, low or no income, living in the Northeastern, Northern and Southern region, daily activity limitations, moderate/severe pain, having one or two or more physical conditions, and low cognitive functioning were negatively associated, and higher physical activity was positively associated with good SRPH. No or low income, residing in the northern region of the country, daily activity limitations, low cognitive functioning, and probable depression were negatively associated with good SRMH, and physical activity was positively associated with good SRMH.

Conclusion
SRPH and SRMH was relatively high rated among the oldest old in Thailand, and influenced by various social, economic, and health-related factors. Special attention should be given to those with no or low income, those living in the non-central regions and those having no or low formal social engagement. Health care and other services should improve physical activity, financial support, and physical and mental care management to promote physical and mental well-being of older adults 80 years and older in Thailand.
Social network analysis of COVID-19 vaccine YouTube videos in Odisha, India: mapping the channel network and analyzing comment sentiment
Authors: Alperstein Neil , Pascual-Ferrá Paola , Ganjoo Rohini , Bhaktaram Ananya , Burleson Julia , Barnett Daniel J. , Jamison Amelia M. , Kluegel Eleanor , Mohanty Satyanarayan , Orton Peter Z. , Parida Manoj , Rath Sidharth , Rimal Rajiv 
Published: July 2023

AbstractIndia has reported more than 35 million confirmed cases of COVID-19 and nearly half a million cumulative deaths. Although vaccination rates for the first vaccine dose are quite high, one-third of the population has not received a second shot. Due to its widespread use and popularity, social media can play a vital role in enhancing vaccine acceptance. This study in a real-world setting utilizes YouTube videos in Odisha, India where the platform has deep penetration among the 18–35 target population, and secondarily their family and peers. Two contrasting videos were launched on the YouTube platform to examine how those videos operate within the broader recommender and subscription systems that determine the audience reach. Video analytics, algorithms for recommended videos, visual representation of connections created, centrality between the networks, and comment analysis was conducted. The results indicate that the video with a non-humorous tone and collectivistic appeal delivered by a female protagonist performed best with regard to views and time spent watching the videos. The results are of significance to health communicators who seek to better understand the platform mechanisms that determine the spread of videos and measures of viewer reactions based on viewer sentiment.
High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils
Authors: Strulovici-Barel Yael , Kaner Robert J. , Crystal Ronald G. 
Published: July 2023

AbstractWhile asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling and angiogenesis in some individuals with this condition. The inflammation is typically characterized as type-2 high (eosinophilic) vs type 2-low (neutrophilic and pauci-granulocytic); we hypothesized that the type-2 high group would be more likely to evidence endothelial dysfunction. As a biomarker of these processes, we hypothesized that nonsmokers with allergic asthma may have elevated plasma levels of endothelial microparticles (EMPs), membrane vesicles that are shed when endothelial cells undergo activation or apoptosis. Total and apoptotic circulating EMPs were measured by fluorescence-activated cell analysis in patients with allergic asthma (n = 29) and control subjects (n = 26), all nonsmokers. When the entire group of patients with asthma were compared to the control subjects, there were no differences in total circulating EMPs nor apoptotic EMPs. However, patients with asthma with elevated levels of IgE and eosinophils had higher levels of apoptotic EMPs, compared to patients with asthma with mildly increased IgE and eosinophil levels. This observation is relevant to precision therapies for asthma and highlights the importance of sub-phenotyping in the condition.
Association between the triglyceride–glucose index and the risk of mortality among patients with chronic heart failure: results from a retrospective cohort study in China
Authors: Zhou You , Wang Chi , Che Hebin , Cheng Liting , Zhu Di , Rao Chongyou , Zhong Qin , Li Zongren , Wang Xiao , Wu Zisheng , He Kunlun 
Published: July 2023

AbstractBackgroundThe triglyceride–glucose (TyG) index has been demonstrated to be a reliable surrogate marker of insulin resistance (IR) and an effective predictive index of cardiovascular (CV) disease risk. However, its long-term prognostic value in patients with chronic heart failure (CHF) remains uncertain.MethodsA total of 6697 consecutive patients with CHF were enrolled in this study. Patients were divided into tertiles according to their TyG index. The incidence of primary outcomes, including all-cause death and CV death, was recorded. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting blood glucose (mg/dL)/2].ResultsDuring a median follow-up of 3.9 years, a total of 2158 (32.2%) all-cause deaths and 1305 (19.5%) CV deaths were documented. The incidence of primary events from the lowest to the highest TyG index tertiles were 50.61, 64.64, and 92.25 per 1000 person-years for all-cause death and 29.05, 39.40, and 57.21 per 1000 person-years for CV death. The multivariate Cox hazards regression analysis revealed hazard ratios for all-cause and CV deaths of 1.84 (95% CI 1.61–2.10;Pfor trend < 0.001) and 1.94 (95% CI 1.63–2.30;Pfor trend < 0.001) when the highest and lowest TyG index tertiles were compared. In addition, the predictive ability of the TyG index against all-cause death was more prominent among patients with metabolic syndrome and those with heart failure with preserved ejection fraction phenotype (bothPfor interaction < 0.05).Furthermore, adding the TyG index to the established model for all-cause death improved the C‑statistic value (0.710 for the established model vs. 0.723 for the established model + TyG index,P < 0.01), the integrated discrimination improvement value (0.011,P < 0.01), the net reclassification improvement value (0.273,P < 0.01), and the clinical net benefit (probability range, 0.07–0.36).ConclusionsThe TyG index was significantly associated with the risk of mortality, suggesting that it may be a reliable and valuable predictor for risk stratification and an effective prognostic indicator in patients with CHF.
The use of RNA-based treatments in the field of cancer immunotherapy
Authors: Chehelgerdi Mohammad , Chehelgerdi Matin 
Published: July 2023

AbstractOver the past several decades, mRNA vaccines have evolved from a theoretical concept to a clinical reality. These vaccines offer several advantages over traditional vaccine techniques, including their high potency, rapid development, low-cost manufacturing, and safe administration. However, until recently, concerns over the instability and inefficient distribution of mRNA in vivo have limited their utility. Fortunately, recent technological advancements have mostly resolved these concerns, resulting in the development of numerous mRNA vaccination platforms for infectious diseases and various types of cancer. These platforms have shown promising outcomes in both animal models and humans. This study highlights the potential of mRNA vaccines as a promising alternative approach to conventional vaccine techniques and cancer treatment. This review article aims to provide a thorough and detailed examination of mRNA vaccines, including their mechanisms of action and potential applications in cancer immunotherapy. Additionally, the article will analyze the current state of mRNA vaccine technology and highlight future directions for the development and implementation of this promising vaccine platform as a mainstream therapeutic option. The review will also discuss potential challenges and limitations of mRNA vaccines, such as their stability and in vivo distribution, and suggest ways to overcome these issues. By providing a comprehensive overview and critical analysis of mRNA vaccines, this review aims to contribute to the advancement of this innovative approach to cancer treatment.
Prognostic roles of hematological indicators for the efficacy and prognosis of immune checkpoint inhibitors in patients with advanced tumors: a retrospective cohort study
Authors: Zheng Fei , Meng Qingju , Zhang Lei , Chen Jingli , Zhao Liyan , Zhou Zhiguo , Liu Yibing 
Published: July 2023

Abstract
Background
Immunocheckpoint inhibitor(ICI) is a major breakthrough in tumor treatment. It can activate the patient’s own immune system and play an anti-tumor role, but not all patients can benefit from it. At present, there is still a lack of effective biomarkers to guide clinical application. The systemic immune inflammation(SII) index reflects the systemic inflammatory state and immune state of patients. Prognostic nutrition index(PNI) can be used to evaluate immune status of patients. Therefore, SII and PNI indexes may have some value in predicting the efficacy and prognosis of immunotherapy, but there is still a lack of relevant research. The purpose of our study was to explore the influence of SII and PNI index on the efficacy and prognosis of immunotherapy.

Methods
A total of 1935 patients treated with ICIs treatment in the Fourth Hospital of Hebei Medical University from November 2016 to October 2021 were retrospectively collected. 435 patients who met the inclusion criteria and did not meet the exclusion criteria. The imaging data, blood results of each patient were collected within 1 week before ICIs treatment. The neutrophil lymphocyte ratio(NLR), platelet lymphocyte ratio(PLR), monocyte lymphocyte ratio(MLR), PNI,systemic inflammatory response index(SIRI),neutrophil-eosinophil ratio(NER) was calculated. The patients were followed up by in-patient, out-patient reexamination and telephone contact, and the efficacy evaluation and survival status were recorded. The deadline of follow-up: January 2021. SPSS-24.0 software was employed for statistical analysis.

Results
Among the 435 patients receiving ICI treatment, 61,236 and 138 patients were evaluated respectively as partial response (PR), stable disease (SD) and progressive disease (PD). The overall response rate(ORR) and disease control rate (DCR) of this cohort were 14.0% and 68.3%, respectively. Median progression-free survival (mPFS) is 4.0 months, The overall survival (mOS) of this cohort is 6.8 months. Multivariate analysis showed that SIRI(Hazard Ratio, HR = 1.304, P = 0.014), PNI (HR = 0.771, P = 0.019), prealbumin (PAB) (HR = 0.596, P = 0.001), and PNI(HR = 0.657, P = 0.008) were independent risk factors for PFS and OS, respectively.

Conclusions
Patients with high SIRI value and low PNI value before ICI treatment have shorter PFS. Patients with higher PNI value have better prognosis. Therefore, hematological indicators may become predictors of immunotherapy.