bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling by PKCδ during Plasticity
Authors: Colgan Lesley A. , Parra-Bueno Paula , Holman Heather L. , Tu Xun , Jain Anant , Calubag Mariah F. , Misler Jaime A. , Gary Chancellor , Oz Goksu , Suponitsky-Kroyter Irena , Okaz Elwy , Yasuda Ryohei 
Published: June 2023

The activity-dependent plasticity of synapses is believed to be the cellular basis of learning. These synaptic changes are mediated through the coordination of local biochemical reactions in synapses and changes in gene transcription in the nucleus to modulate neuronal circuits and behavior. The protein kinase C (PKC) family of isozymes has long been established as critical for synaptic plasticity. However, because of a lack of suitable isozyme-specific tools, the role of the novel subfamily of PKC isozymes is largely unknown. Here, through the development of fluorescence lifetime imaging-fluorescence resonance energy transfer activity sensors, we investigate novel PKC isozymes in synaptic plasticity in CA1 pyramidal neurons of mice of either sex. We find that PKCδ is activated downstream of TrkB and DAG production, and that the spatiotemporal nature of its activation depends on the plasticity stimulation. In response to single-spine plasticity, PKCδ is activated primarily in the stimulated spine and is required for local expression of plasticity. However, in response to multispine stimulation, a long-lasting and spreading activation of PKCδ scales with the number of spines stimulated and, by regulating cAMP response-element binding protein activity, couples spine plasticity to transcription in the nucleus. Thus, PKCδ plays a dual functional role in facilitating synaptic plasticity.SIGNIFICANCE STATEMENTSynaptic plasticity, or the ability to change the strength of the connections between neurons, underlies learning and memory and is critical for brain health. The protein kinase C (PKC) family is central to this process. However, understanding how these kinases work to mediate plasticity has been limited by a lack of tools to visualize and perturb their activity. Here, we introduce and use new tools to reveal a dual role for PKCδ in facilitating local synaptic plasticity and stabilizing this plasticity through spine-to-nucleus signaling to regulate transcription. This work provides new tools to overcome limitations in studying isozyme-specific PKC function and provides insight into molecular mechanisms of synaptic plasticity.
Characteristics of Adolescents Who Use Secure Messaging on a Health System’s Patient Portal
Authors: Hoopes Andrea J. , Cushing-Haugen Kara L. , Coley R. Yates , Fuller Sharon , White Cicely , Ralston James D. , Mangione-Smith Rita 
Published: June 2023

OBJECTIVES
To determine adolescent characteristics associated with patient portal secure messaging use within a health system.

METHODS
This study analyzed monthly data from individuals aged 13 to 17 who met study eligibility criteria from 2019 to 2021. The primary outcome was any secure messages sent from an adolescent’s account during each observed month. Unadjusted and adjusted associations between adolescent characteristics and secure messaging use were assessed using generalized estimating equations with log link and binomial variance.

RESULTS
Of 667 678 observed months, 50.8% occurred among males who were not transgender, 51.5% among those identifying as non-Hispanic white, and 83.3% among the privately insured. The adjusted relative risks of secure messaging use were significantly higher for individuals with female sex and transgender identities (female sex, not transgender: adjusted relative risk [aRR] 1.41, 95% confidence interval [CI] 1.31–1.52; male sex, transgender: aRR 2.39, CI 1.98–2.90, female sex, transgender: aRR 3.01, 95% CI 2.63–3.46; referent male sex, not transgender), those with prior portal use (aRR 22.06, 95% CI 20.48–23.77; referent no use) and those with a recent preventive care visit (aRR 1.09, 95% CI 1.02–1.16; referent no recent visits). The adjusted relative risks of portal secure messaging use were significantly lower among those with public insurance (aRR 0.58, 95% CI 0.50–0.67; referent private).

CONCLUSIONS
Adolescents who sent patient portal secure messages differed from those who did not. Interventions to encourage secure messaging use may require tailoring based on patient characteristics.
Autonomía, centralidad y persistencia: comunas, movimiento indígena y el derecho a la ciudad en Quito
Authors: Rayner Jeremy , De Veintimilla Ana María 
Published: June 2023

Este artículo se basa en etnografía realizada con defensores de las comunas en Quito, para dialogar críticamente con la teoría y la política del derecho a la ciudad. Los activistas comunales –en su mayoría afiliados al movimiento indígena– reclaman con fuerza los derechos a la producción y apropiación democrática del espacio que defienden los teóricos del derecho a la ciudad, ya que promueven la autogestión comunal y la autoridad de las asambleas comunales sobre los procesos de urbanización. Al mismo tiempo, han hecho poco uso de la garantía del derecho a la ciudad estipulado en la Constitución. Al exponer cuidadosamente los puntos de convergencia entre la teoría lefebvriana del derecho a la ciudad y las luchas comunales, también identifico sus límites y contradicciones, especialmente dos: 1) la tensión entre “el poder colectivo para reconfigurar el proceso de urbanización” y las formas y significados fijos de “la ciudad”, y 2) la tensión entre alcanzar el “derecho a la centralidad” a través de la promoción de la participación en un centro urbano concentrado o mediante la multiplicación de centros. Una teoría crítica de la urbanización debería dar cuenta de estas tensiones y de la diversidad de respuestas políticas a las mismas.
Automated Stand-alone Surgical Safety Evaluation for Laparoscopic Cholecystectomy (LC) using Convolutional Neural Network and Constrained Local Models (CNN-CLM)
Authors: Fahad Jabbar Saadya 
Published: June 2023

In this golden age of rapid development surgeons realized that AI could contribute to healthcare in all aspects, especially in surgery. The aim of the study will incorporate the use of Convolutional Neural Network and Constrained Local Models (CNN-CLM) which can make improvement for the assessment of Laparoscopic Cholecystectomy (LC) surgery not only bring opportunities for surgery but also bring challenges on the way forward by using the edge cutting technology. The problem with the current method of surgery is the lack of safety and specific complications and problems associated with safety in each laparoscopic cholecystectomy procedure. When CLM is utilize into CNN models, it is effective at predicting time series tasks like identifying the sequence of events in the Laparoscopic Cholecystectomy (LC). This study will contribute to show the effectiveness of CNN-CLM approach on laparoscopic cholecystectomy, which will frequently focus on surgical computer vision analysis of surgical safety and related applications. The method of study is deep learning based CNN-CLM to better detect nominal safety as well as unsafe practices around the critical view of safety and AI-based grading scale. The general design flow of AI-recognition of surgical safety is firstly collecting safety surgical videos for frame segmenting and phase according to the image context by surgeon reviewer by CNN-CLM. For this advance research, the dataset is splatted into three main parts where 70% of which is used for training, 15% of which is used for testing and the rest for the cross validation, to achieve the accuracy up to 98.79% of this specific research. For result part, different metrics of CNN-CLM to evaluate the performance of the proposed model of safety in surgery. The study uses one of the top three performing methods CNN-CLM for the evaluation yields and anatomical structures in laparoscopic cholecystectomy surgery.
Comparative evaluation of propofol, thiopentone and etomidate on induction time, intubation response and recovery time during laparoscopic surgery under general Anaesthesia
Authors: Kumar Ramesh , Thakur Sooshrut , Sharma Aarti , Pathania Jyoti , Thakur Garima 
Published: June 2023

: Optimal choice of inducing agent can partially modify the post induction hypotension, having a reported incidence of 9-40% in various studies. So, we compared the induction and recovery profile of the routinely available induction agents.This prospective randomized, comparative study was carried out on 120, ASA 1 and II patients undergoing routine laparoscopic cholecystectomy. Patient received either thiopentone 5 mg/kg, propofol 2.0 mg/kg or 0.3mg/kg injection etomidate at induction in group T, P and E respectively. The time taken from the administration of inducing agent to loss of eyelash reflex was noted. Heart rate, systolic, diastolic and mean arterial pressure, SpO2 was recorded at 1, 2, 3, 4, 5, 6 minutes and every five minutes after intubation. Steward score and the vitals were noted every 5 minutes after extubation till 30 minutes. It was noted that how long it took to get a Steward score of 6.The mean induction time (sec) was 49.85 ±2.54 in group T, 43.45 ±2.66 in group P and 52.675 ±2.11 in group E. (p&#60;0.0001). The increase in mean heart rate from baseline upon induction and intubation was (10%, 31% in group T), (3%, 23% in group E) and (-7%, 16% in group P) (p&#60;0.0001). Post induction decrease in systolic, diastolic and mean blood pressures observed in group T was (-9%, -4.5%, -6%), (-12.8%, -9.8%, -11%), in group P and (-4.6%, -1.7%, -2.9%) in group E. (p&#60;0.0001). Post intubation increase in systolic, diastolic and mean blood pressures was (21.76%, 18%, 19.7%) in group T, (16%, 8.1%, 11.7%) in group E and (9.6%, 0%, 4%) in group P. Mean recovery time in min was 5.87 ±0.23 min with propofol, 6.97 ±0.28 with etomidate and 8.96 ±0.28 with thiopentone. (p&#60;0.0001). : Amongst the three agents, we recommend propofol as preferred agent for induction due to faster induction, better attenuation of intubation response, faster recovery and stable hemodynamic parameters.
INSTITUTIONAL RESOLUTION OF NON-TERRITORIAL INTERETHNIC CONFLICTS: ADAPTATION AND INTEGRATION STRATEGIES
Authors: Filyaeva Alina I. 
Published: June 2023

Aim. To reveal the differences and similarities in the implementation of integration and adaptation strategies in institutional settlement of non-territorial interethnic conflicts.Methodology. The author applies comparative analysis and event analysis of France, Italy and Austria cases of institutional settlement of non-territorial interethnic conflicts in which Muslim migrant communities are involved.Results. The author concluded that the national institutions which implement adaptation policy are similar to the integrative ones – both strategies rely not so much on formal as on informal institutions. The main differences are the types of the immigrant movements that are involved in a dialogue with the state and degrees of involvement of immigrant ethnic minorities in the cultural life of the host state.Research implications. The research materials can be used by teachers when preparing special courses on interethnic conflicts resolution.
Iranian Arabic teachers’ perception of applying educational software
Authors: Hajizadeh Mahin , Panahi Sayad 
Published: June 2023

Educational technology with its wide variety of usage has assisted teachers and learners to learn from the material which has been produced and reviewed by experts. However, the question may come to mind concerning the number of teachers applying such productions, how they perceive such productions, and if they use them, for what purpose they use them. This study was designed to investigate the Iranian Arabic teachers’ perception of applying educational software. To find the answer to these questions, the researchers have developed a survey and interview with 29 Arabic teachers in Ahar. The results from the interview and survey indicated that more than half of the teachers apply such productions for teaching grammar and pronunciation more than other skills and sections of the book. However, they also believe that not all parts of the available software are adequate for usage. Thus, the findings of the present study might be useful for Arabic language supervisor teachers and educational software designers, to improve the quality of the software and also to motivate the teachers to use them in their classrooms.
Keywords: Arabic language; educational software; foreign language.
Social Diversity Model: Inheritance of Mutual Collaboration in the Indonesian Hindu-Muslim Society at Tengger, Lumajang
Authors: Chalim Abdul , Muslim Shohib , Al-Fatih Sholahuddin , Fadloli  , Nur Asrul Ibrahim 
Published: June 2023

This study aims to describe and analyze how the cultural inheritance of a collaborative Hindu-Muslim community occurs in Tengger Village, Lumajang Regency, East Java, Indonesia using the concept of ta'âwun as the theoretical framework. The research is qualitative with a multi-case study type. Data were collected using in-depth interviews to relevant parties, participant observation at the research locus, and documentation to collect information about the history and general description of the Tengger people. Meanwhile, data analysis is by examining ta’âwun concept by presenting and condensing data then drawing conclusions. Researchers check the data validity using credibility, transferability, dependability, and confirmability. This research resulted in the following: the cultural inheritance of mutual collaboration in the community is through; 1) becoming role model to show respect on others’ right, 2) establishing and maintaining community organization, 3) organizing customary events with committees coming from the whole part of the community.
Megawati Soekarno Putri Government Policy In Dealing With The Effects Of The Bali Bombings I In 2002
Authors: Hidayah David , Marjono Marjono , Sumardi Sumardi , Umamah Nurul , Surya Riza Afita 
Published: June 2023

The Bali Bombing I in 2002 was one of the events caused by terrorists in Indonesia. Terror acts carried out in the Bali region with bombings killed 202 people. The incident occurred when the Indonesian government did not yet have laws and regulations governing the handling of explosions. The Bali Bombing I had a wide impact on the world of Bali tourism. The explosion destroyed the Paddy's Pub cafe, Sari Club and the United States Consulate. More than 519people were recorded, consisting of 202 people died and 317 people were outpatient. The Bali Bombing I caused many problems that had to be handled by the Megawati Soekarnoputri Government, among others, the obstacles to assistance from the central government to the Bali local government, the handling of legislation did not yet exist, limited hospital installations, reconstruction and normalization in the tourism sector had not yet been implemented. recovered for tourism promotion.
Keywords: Government, Handling, Bali bomb I.
Development Of Infographic Media Based On Qr Code Situs Duplang In History Learning With ASSURE Model
Authors: Ar Hofi Hannan , Soepeno Bambang , Na'im Mohammad , Puji Rully Putri Nirmala , Triyanto Jefri Rieski , Prasetyo Guruh 
Published: June 2023

Learning media that serves as a communication tool used in learning, but learning media ccan be beneficial as a means in education which helps the teaching process so that learning does not seem static, so learning can be effective. 05 Jember, SMAN 02 Tanggul and SMAN Arjasa. (1) 66% of educators have difficulties in teaching history in the application of media learning, 33% in teaching methods; (2) The learning method used by educators has used the 100% Lecture method, 66% Problem Solving, 66% Discussion; (3) 66% educators add teaching media in the form of visual Power Point and 66% Video; (4) Educators have obstacles in the application of media in 66% Difficulty in designing learning media, 33% Difficulty in developing learning media. The facilities and infrastructure in the three schools are adequate, from Wi-Fi to projectors, but they are still lacking in utilization in the learning process Based on the questionnaire analytical of learning styles, it must be said that visual teaching styles are 48.3%, audio learning styles are 20.9% and kinesthetic learning styles are 40.7%. improvement of student teaching outcomes after use Infographics teaching media based on Qr Code. The increase in learning outcomes that increased significantly between the pre-test and post-test scores increased the average learning outcomes of students by 87.47%. This Qr Code-based Infographic Media Duplang Site has been developed by adding ideas and concepts to the media.
Keywords: Infografis, Qr Code, Situs Duplang
An outline of the professional quality of teachers who teach children with special needs
Authors: Darawsheh Saddam Rateb , Asha Intisar Khalil Khalil , AbuSaif Radwan , Alhejoj Arwa Faisal , Khasawneh Mohamad Ahmad Saleem 
Published: June 2023

The term "professional quality of life," sometimes abbreviated as "ProQOL," refers to an individual's evaluation of the positive aspects of his or her working life. This frame may be categorized in two different ways. Compassion Fatigue (CF) is undesirable, yet Compassion Satisfaction (CS) motivates people to feel good about their job and, as a consequence, assist other people. Compassionate fulfillment is one of the most admirable qualities (CS). This study's goal is to get a thorough understanding of ProQOL in the teaching profession for kids with special needs because the great majority of prior research on ProQOL was conducted on health professionals. This quantitative study did not use any type of experimental approach, yet it included the participation of 171 students with special needs educators. The obtained data indicate that teachers of students with special needs have a generally favorable perception regarding the environment in which they work. To provide one illustration: To mention one specific example, this does not always indicate that there are low incidences of STS or burnout. The majority of students with special needs teachers (77%) were operating at a level of burnout that was classified as Medium-High, and the majority of those instructors (72%) also had an STS level that was classified as Medium-High. The study recommended using the appropriate programs that raise the teachers’ professional levels to match the requirements of teaching students with special needs.
Using learning games for fourth-grade students to teach Vietnamese lessons and teachers' perspectives on learning games
Authors: Le Lan-Anh Thi , Tran Quynh-Nga Thi , Nguyen Kim-Dung Thi , Xuan Ha Thi Nguyet 
Published: June 2023

Students can learn in a meaningful way through the use of educational games. When students apply their skills and information in order to progress through a game, a huge degree of engagement is generated among them in the classroom as a result both their capabilities and their learning increase. 153 children from primary schools in Vietnam participated in this research. The children were split into two groups: an experimental and a control group. Both groups participated in two sessions of word and sentence practice as well as spelling instruction. According to the findings of the study, the educational outcomes of the students are greatly improved when games are used in their classrooms. In addition, research has shown that some teachers are against the use of games in the classroom since it makes it more difficult to prepare educational materials. Some educators believe that playing educational games is a more effective method of instruction as it allows for greater flexibility during the learning process. This makes a contribution to the theoretical framework that is necessary to guide educators and instructors in the process of improving learning game programs for children in primary schools and other learners.
Novel Therapeutic Strategies in the Treatment of Systemic Sclerosis
Authors: Gumkowska-Sroka Olga , Kotyla Kacper , Mojs Ewa , Palka Klaudia , Kotyla Przemyslaw 
Published: June 2023

Citation: Lastname, F.; Lastname, F.; Last-name, F. Title. Phar-maceuticals 2022, 15, x. https://doi.org/10.3390/xxxxx
Academic Editor: Firstname Lastname
Received: date
Accepted: date
Published: date
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Copyright: © 2023 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons
1Olga Gumkowska-Sroka, 2Kacper Kotyla, 3Ewa Mojs, 2Klaudia Palka, 1,2*Przemysław Kotyla
1.	Department of Rheumatology and Clinical Immunology Voivodeship Hospital No5 in Sosnowiec Medical University of Silesia Katowice, Poland
2.	Department of Internal Medicine Rheumatology and Clinical Immunology Medical University of Silesia Katowice , Poland
3.	3. Department of Clinical Psychology, Poznan University of Medical Sciences Poznan, Poland
*Correspondence: Prof Przemysław Kotyla Department of Internal Medicine Rheumatology and Clinical Immunology Medical University of Silesia, Katowice, Poland-
Summary
Systemic sclerosis is a connective tissue disease of unknown origin and unpredictable course, with both cutaneous and internal organ manifestations. In spite of enormous progress in rheumatology and clinical immunology, the background of diseases is largely unknown and no specific therapy exists.
The therapeutic approach to the disease is aimed to treat and preserve the function of internal organs, and this approach is commonly referred to as an organ-based treatment. However, in modern times data from the other branches of medicine may help to treat disease-related complications, making it possible to find a group of drugs to be utilized in the treatment of the disease. In this review, we present possible therapeutic options aiming to stop the progression of fibrotic processes, restore aberrant immune response, stop improper signalling from proinflammatory cytokines, and halt the production of disease-related autoantibodies.
Pengenalan dan Pembuatan Ornamen Sebagai Bentuk Pembelajaran Sejarah dan Kebudayaan
Authors: Lestari Siti Indah , Ramadhani Ivo , Bintarto Joko , Salma Afifah 
Published: June 2023

<p>Ornamen atau sering disebut desain dekoratif adalah seni yang digunakan dengan tujuan memperindah. Penerapan ornamen pada bidang interior banyak diterapkan pada lantai, plafon, dinding, bukaan dan elemen interior lainnya, selain tujuan memperindah, penggunaan ornamen pada elemen interior menyimpan fungsi dan makna didalamnya yang tidak banyak diketahui oleh banyak kalangan masyarakat. Menurut sejarawan arsitektur Sir John Summerson, dekorasi dan ornamen telah menjadi saksi dalam peradaban sejak awal sejarah dari "Arsitektur Mesir Kuno" hingga penurunan eksistensi ornamen pada abad ke-20. Tujuan pelaksanaan pengabdian masyarakat ini mengenalkan ornamen dan pembuatan ornamen secara digitalisasi kepada kaum muda khususnya anak SMK agar dapat memahami sejarah budaya melalui ornamen dan meningkatkan kompetensi dalam bidang digitalisasi sesuai dengan tuntutan zaman. Target sasarannya adalah SMK Tarbiyah Islamiyah Medan, kegiatan ini dilakukan dengan beberapa tahapan yakni pemaparan materi mengenai ornamen dekoratif dari zaman mesir kuno hingga saat ini, pengenalan tool software dan pendampingan pembuatan ornamen secara digitalisasi. Hasil dari kegiatan yaitu siswa mengetahui sejarah seni budaya dari desain ornamen dan mampu membuat desain dengan teknik eksplorasi bentuk ornamen dari ide pemikiran secara digitalisasi dengan memanfaatkan kecanggihan teknologi software desain.</p><p> </p><p><strong>Kata kunci</strong> : <em>ornamen; sejarah kebudayaan; pembelajaran</em></p>