bluuebunny/crossref_metadata_2025_split huggingface dataset:
The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice
Authors: Wang Cao , Qiao Shupei , Zhao Yufang , Tian Hui , Yan Wei , Hou Xiaolu , Wang Ruiqi , Zhang Bosong , Yang Chaofan , Zhu Fuxing , Jiao Yanwen , Jin Jiaming , Chen Yue , Tian Weiming 
Published: February 2023

AbstractThe main hallmark of myocardial substrate metabolism in cardiac hypertrophy or heart failure is a shift from fatty acid oxidation to greater reliance on glycolysis. However, the close correlation between glycolysis and fatty acid oxidation and underlying mechanism by which causes cardiac pathological remodelling remain unclear. We confirm that KLF7 simultaneously targets the rate-limiting enzyme of glycolysis, phosphofructokinase-1, liver, and long-chain acyl-CoA dehydrogenase, a key enzyme for fatty acid oxidation. Cardiac-specific knockout and overexpression KLF7 induce adult concentric hypertrophy and infant eccentric hypertrophy by regulating glycolysis and fatty acid oxidation fluxes in male mice, respectively. Furthermore, cardiac-specific knockdown phosphofructokinase-1, liver or overexpression long-chain acyl-CoA dehydrogenase partially rescues the cardiac hypertrophy in adult male KLF7 deficient mice. Here we show that the KLF7/PFKL/ACADL axis is a critical regulatory mechanism and may provide insight into viable therapeutic concepts aimed at the modulation of cardiac metabolic balance in hypertrophied and failing heart.
Fundamental quantum limits of magnetic nearfield measurements
Authors: Mechel Chen , Nemirovsky Jonathan , Cohen Eliahu , Kaminer Ido 
Published: February 2023

AbstractMajor advances in the precision of magnetic measurements bring us closer to quantum detection of individual spins at the single-atom level. On the quest for reducing both classical and quantum measurement noise, it is intriguing to look forward and search for precision limits arising from the fundamental quantum nature of the measurement process itself. Here, we present the limits of magnetic quantum measurements arising from quantum information considerations, and apply these limits to a concrete example of magnetic force microscopy (MFM). We show how such microscopes have a fundamental limit on their precision arising from the theory of imperfect quantum cloning, manifested by the entanglement between the measured system and the measurement probe. We show that counterintuitively, increasing the probe complexity decreases both the measurement noise and back action, and a judicious design of the magnetic interaction reveals optimal schemes already at spin-1 probes.
Livestock exposure to future cumulated climate-related stressors in West Africa
Authors: Brouillet Audrey , Sultan Benjamin 
Published: February 2023

AbstractA large range of climate change impacts is expected during the twenty-first century in vulnerable regions such as West Africa, where local populations largely rely on livestock systems as their main food production and income source. As climate change threatens livestock systems in various ways, here we assess how regional livestock could be exposed to cumulated climate-related stressors in the future. Using the world’s largest multi-model climate impacts simulations database ISIMIP, we find that a large part of West Africa will experience at least 5–6 cumulated multiple climate stressors before the 2030s, including amplified severe heat stress conditions and flood risks. Consequently, about 30% of the current total regional livestock could be exposed to these cumulated stressors, with sheep and goat as the most affected species. This paper brings new quantifications that may help policy makers to prioritize decisions that could prepare local populations to face multiple climate-related impacts.
Upside down sulphate dynamics in a saline inland lake
Authors: Margalef-Marti Rosanna , Sebilo Mathieu , Thibault De Chanvalon Aubin , Anschutz Pierre , Charbonnier Céline , Lauga Béatrice , Gonzalez-Alvarez Ivan , Tessier Emmanuel , Amouroux David 
Published: February 2023

AbstractThe sulphur cycle has a key role on the fate of nutrients through its several interconnected reactions. Although sulphur cycling in aquatic ecosystems has been thoroughly studied since the early 70’s, its characterisation in saline endorheic lakes still deserves further exploration. Gallocanta Lake (NE Spain) is an ephemeral saline inland lake whose main sulphate source is found on the lake bed minerals and leads to dissolved sulphate concentrations higher than those of seawater. An integrative study including geochemical and isotopic characterization of surface water, porewater and sediment has been performed to address how sulphur cycling is constrained by the geological background. In freshwater and marine environments, sulphate concentration decreases with depth are commonly associated with bacterial sulphate reduction (BSR). However, in Gallocanta Lake sulphate concentrations in porewater increase from 60 mM at the water–sediment interface to 230 mM at 25 cm depth. This extreme increase could be caused by dissolution of the sulphate rich mineral epsomite (MgSO4·7H2O). Sulphur isotopic data was used to validate this hypothesis and demonstrate the occurrence of BSR near the water–sediment interface. This dynamic prevents methane production and release from the anoxic sediment, which is advantageous in the current context of global warming. These results underline that geological context should be considered in future biogeochemical studies of inland lakes with higher potential availability of electron acceptors in the lake bed compared to the water column.
Exploring the mechanistic pathways of how social network influences social norms in adolescent smoking prevention interventions
Authors: Montes Felipe , Blanco Martha , Useche Andres F. , Sanchez-Franco Sharon , Caro Carlos , Tong Lei , Li Jie , Zhou Huiyu , Murray Jennifer M. , Sarmiento Olga L. , Kee Frank , Hunter Ruth F. 
Published: February 2023

AbstractWe know little about how smoking prevention interventions might leverage social network structures to enhance protective social norms. In this study we combined statistical and network science methods to explore how social networks influence social norms related to adolescent smoking in school-specific settings in Northern Ireland and Colombia. Pupils (12–15 years old) participated in two smoking prevention interventions in both countries (n = 1344). A Latent Transition Analysis identified three groups characterized by descriptive and injunctive norms towards smoking. We employed a Separable Temporal Random Graph Model to analyze homophily in social norms and conducted a descriptive analysis of the changes in the students’ and their friends’ social norms over time to account for social influence. The results showed that students were more likely to be friends with others who had social norms against smoking. However, students with social norms favorable towards smoking had more friends with similar views than the students with perceived norms against smoking, underlining the importance of network thresholds. Our results support the notation that the ASSIST intervention takes advantage of friendship networks to leverage greater change in the students' smoking social norms than the Dead Cool intervention, reiterating that social norms are subject to social influence.
The degree of urbanisation reduces wild bee and butterfly diversity and alters the patterns of flower-visitation in urban dry grasslands
Authors: Herrmann Johann , Buchholz Sascha , Theodorou Panagiotis 
Published: February 2023

AbstractInsect-provided pollination services are increasingly threatened due to alarming declines in insect pollinator populations. One of the main threats to insect pollinators and consequently pollination is urbanisation. Here, we investigate the effects of local habitat quality (patch size, flowering plant richness, bare soil cover, vegetation structure), degree of urbanisation (impervious surfaces) and 3D connectivity on bee, hoverfly and butterfly flower visitors and plant-flower visitor networks in flower-rich urban dry grasslands. Overall, the degree of urbanisation and the quality of the local habitat influenced the flowering plant and pollinator communities. Although flowering plant abundance increased with urbanisation, bee species richness and butterfly species richness decreased with increasing impervious surfaces. Flowering plant richness and ground nesting resource availability were positively related to bee richness and local vegetation structure boosted hoverfly and butterfly visitation rates. In terms of plant–pollinator interactions, insect pollinators visited a lower proportion of the available flowering plants in more urbanised areas and network modularity and specialisation increased with patch size. Our findings show that urban dry grasslands are valuable habitats for species-rich pollinator communities and further highlight the importance of minimizing the intensity of urbanisation and the potential of local management practices to support insect biodiversity in cities.
Classification of electrically-evoked potentials in the parkinsonian subthalamic nucleus region
Authors: Rosing Joshua , Doyle Alex , Brinda AnneMarie , Blumenfeld Madeline , Lecy Emily , Spencer Chelsea , Dao Joan , Krieg Jordan , Wilmerding Kelton , Sullivan Disa , Best Sendréa , Mohanty Biswaranjan , Wang Jing , Johnson Luke A. , Vitek Jerrold L. , Johnson Matthew D. 
Published: February 2023

AbstractElectrically evoked compound action potentials (ECAPs) generated in the subthalamic nucleus (STN) contain features that may be useful for titrating deep brain stimulation (DBS) therapy for Parkinson’s disease. Delivering a strong therapeutic effect with DBS therapies, however, relies on selectively targeting neural pathways to avoid inducing side effects. In this study, we investigated the spatiotemporal features of ECAPs in and around the STN across parameter sweeps of stimulation current amplitude, pulse width, and electrode configuration, and used a linear classifier of ECAP responses to predict electrode location. Four non-human primates were implanted unilaterally with either a directional (n = 3) or non-directional (n = 1) DBS lead targeting the sensorimotor STN. ECAP responses were characterized by primary features (within 1.6 ms after a stimulus pulse) and secondary features (between 1.6 and 7.4 ms after a stimulus pulse). Using these features, a linear classifier was able to accurately differentiate electrodes within the STN versus dorsal to the STN in all four subjects. ECAP responses varied systematically with recording and stimulating electrode locations, which provides a subject-specific neuroanatomical basis for selecting electrode configurations in the treatment of Parkinson’s disease with DBS therapy.
Heat and mass transfer of micropolar liquid flow due to porous stretching/shrinking surface with ternary nanoparticles
Authors: Vanitha G. P. , Mahabaleshwar U. S. , Hatami M. , Yang Xiaohu 
Published: February 2023

AbstractThe present investigation is carried out to predict the flow characteristics of a micropolar liquid that is infused with ternary nanoparticles across a stretching/shrinking surface under the impact of chemical reactions and radiation. Here, three dissimilarly shaped nanoparticles (copper oxide, graphene and copper nanotubes) are suspended in H2O to analyse the characteristics of flow, heat and mass transfer. The flow is analysed using the inverse Darcy model, while the thermal analysis is based on the thermal radiation. Furthermore, the mass transfer is examined in light of the impact of first order chemically reactive species. The considered flow problem is modelled resulting with the governing equations. These governing equations are highly non linear partial differential equations. Adopting suitable similarity transformations partial differential equations are reduced to ordinary differential equations. The thermal and mass transfer analysis comprises two cases: PST/PSC and PHF/PMF. The analytical solution for energy and mass characteristics is extracted in terms of an incomplete gamma function. The characteristics of a micropolar liquid are analysed for various parameters and presented through graphs. The impact of skin friction is also considered in this analysis. The stretching and rate of mass transfer have a large influence on the microstructure of a product manufactured in the industries. The analytical results produced in the current study seem to be helpful in the polymer industry for manufacturing stretched plastic sheets.
Efficacy of high-intensity interval training for improving mental health and health-related quality of life in women with polycystic ovary syndrome
Authors: Patten Rhiannon K. , McIlvenna Luke C. , Moreno-Asso Alba , Hiam Danielle , Stepto Nigel K. , Rosenbaum Simon , Parker Alexandra G. 
Published: February 2023

AbstractWomen with PCOS have substantially greater symptoms of depression and anxiety, and a lower health-related quality of life (HRQoL) compared to women without PCOS. The aim of this study was to determine if high-intensity interval training (HIIT) could provide greater improvements in mental health outcomes than standard moderate-intensity continuous training (MICT). Twenty-nine overweight women with PCOS aged 18–45 years were randomly assigned to 12 weeks of either MICT (60–75% HRpeak, N = 15) or HIIT (> 90% HRpeak, N = 14). Outcome measures included symptoms of depression, anxiety and stress (DASS-21), general HRQoL (SF-36) and PCOS specific HRQoL (PCOSQ) collected at baseline and post-intervention. Reductions in depression (Δ − 1.7, P = 0.005), anxiety (Δ − 3.4, P < 0.001) and stress (Δ − 2.4, P = 0.003) scores were observed in the HIIT group, while MICT only resulted in a reduction in stress scores (Δ − 2.9, P = 0.001). Reductions in anxiety scores were significantly higher in the HIIT group compared to the MICT group (β = − 2.24, P = 0.020). Both HIIT and MICT significantly improved multiple domain scores from the SF-36 and PCOSQ. This study highlights the potential of HIIT for improving mental health and HRQoL in overweight women with PCOS. HIIT may be a viable strategy to reduce symptoms of depression and anxiety in women with PCOS, however, large-scale studies are required to confirm these findings.Trial registration number: ACTRN12615000242527.
Research on longitudinal vibration suppression of underwater vehicle shafting based on particle damping
Authors: Liu Jie , Deng Tianyang , Chang Xingshan , Sun Feng , Zhou Jianhui 
Published: February 2023

AbstractA particle damper is applied to suppress the longitudinal vibration of underwater vehicle shafting in order to reduce vibration level and improve silence and stealth of underwater vehicles. The model of rubber-coated steel particle damper was established with discrete element method and PFC3D simulation software, the damping energy consumption law of collision and friction between particle and damper and between particle and particle investigated, the effects of particle radius, mass filling ratio, cavity length, excitation frequency, excitation amplitude, rotating speed and both stacking and motion states of particles on the system vibration suppression were discussed, and the bench test was carried out to verify the law. It revealed the mechanism of longitudinal vibration suppression of particle damping, established the intrinsic relationship between of total energy consumption of particle and vibration of system, and put forward the evaluating method of longitudinal vibration suppression effect by total energy consumption of particle and vibration reduction ratio. The research results show that the mechanical model of particle damper is reasonable and the simulation data is reliable; the rotating speed, mass filling ratio and cavity length have significant effects on the total energy consumption of particle and vibration reduction ratio.
Impact of mobile health on maternal and child health service utilization and continuum of care in Northern Ghana
Authors: Nuhu Abdul Ganiyu Kantamah , Dwomoh Duah , Amuasi Susan Ama , Dotse-Gborgbortsi Winfred , Kubio Chrysantus , Apraku Edward Anane , Timbire Jonas Kolong , Nonvignon Justice 
Published: February 2023

AbstractMaternal and child mortality are of public health concern. Most of these deaths occur in rural communities of developing countries. Technology for maternal and child health (T4MCH) is an intervention introduced to increase Maternal and Child Health (MCH) services utilization and continuum of care in some health facilities across Ghana. The objective of this study is to assess the impact of T4MCH intervention on MCH services utilization and continuum of care in the Sawla-Tuna-Kalba District in the Savannah Region of Ghana. This is a quasi-experimental study with a retrospective review of records of MCH services of women who attended antenatal services in some selected health centers in the Bole (comparison district) and Sawla-Tuna-Kalba (intervention district) of the Savannah region, Ghana. A total of 469 records were reviewed, 263 in Bole and 206 in Sawla-Tuna-Kalba. A multivariable modified Poisson and logistic regression models with augmented inverse-probability weighted regression adjustment based on propensity scores were used to quantify the impact of the intervention on service utilization and continuum of care. The implementation of T4MCH intervention increased antenatal care attendance, facility delivery, postnatal care and continuum of care by 18 percentage points (ppts) [95% CI - 17.0, 52.0], 14 ppts [95% CI 6.0%, 21.0%], 27 ppts [95% CI 15.0, 26.0] and 15.0 ppts [95% CI 8.0, 23.0] respectively compared to the control districts. The study showed that T4MCH intervention improved antenatal care, skilled delivery, postnatal services utilization, and continuum of care in health facilities in the intervention district. The intervention is recommended for a scale-up in other rural areas of Northern Ghana and the West-African sub-region.
Butyrate limits human natural killer cell effector function
Authors: Zaiatz-Bittencourt Vanessa , Jones Fiona , Tosetto Miriam , Scaife Caitriona , Cagney Gerard , Jones Evan , Doherty Glen A. , Ryan Elizabeth J. 
Published: February 2023

AbstractThe gut microbiota regulates chronic inflammation and has been implicated in the pathogenesis of a broad spectrum of disease including autoimmunity and cancer. Microbial short-chain fatty acids (SCFAs) e.g., butyrate have demonstrated immunomodulatory effects and are thought to be key mediators of the host-microbiome interaction. Here, we investigated the effect of butyrate on effector functions of blood derived human NK cells stimulated for 18 h with a combination of IL-12/IL-15, a potent mix of cytokines that drive NK cell activation. We show that butyrate has a strong anti-inflammatory effect on NK cells. NK cells cultured in the presence of butyrate expressed lower levels of activating receptors (TRAIL, NKp30, NKp44) and produced lower levels of cytokines (IFNγ, TNF-α, IL-22, granzyme B, granzyme A, perforin) in response to IL-12/IL-15. Butyrate restricted NK cell function by downregulation of mTORC1 activity, c-Myc mRNA expression and metabolism. Using a shotgun proteomic approach, we confirmed the effect of butyrate on NK cell cytokine signaling and metabolism and identified BRD2, MAT2A and EHD1 as downstream mediators of these effects. This insight into the immunomodulatory activity of butyrate on human NK cell function might help to develop new ways to limit NK cell function during chronic inflammation.
Improvement of trip generation rates for mixed-use development in Klang Valley, Malaysia
Authors: Goh Boon Hoe , Yuen Choon Wah , Onn Chiu Chuen 
Published: February 2023

AbstractMixed-use developments (MXDs) are a single development project that integrates and interacts with different land uses. Traffic is estimated to be reduced with such development. However, there is no standard procedure is available to estimate the MXD trip generation rates in Malaysia. The Malaysian Trip Generation Manual (MTGM) is the guidelines currently been used to forecast future trips for single land use. If the trip generation rates for multiple land uses are summed as MXD trips, the total trips will be overestimated without considering the internal trip capture. This study aimed to establish an improved method for estimating the MXD trip generation rates. Four MXD observation sites were selected in Klang Valley. Traffic survey counts were conducted considering person-trip, including passengers in vehicles and pedestrians. The results revealed that the MXD trip generation rates with MTGM were higher than actual traffic counts during peak hours. The MXD adjustment factor was established as 0.63, which can be applied by multiplying the MTGM trip generation rates to reduce the generated MXD trips in PCU per hour. This research has formulated a new data collection method by integrating person counts, alongside with new guidelines for pedestrian counts. The findings provide an option to adjust the MXD trips and prevent from overestimating future trips, which may result in overdevelopment and spending on mitigation measures in urban planning and road infrastructure.
Development of Self-Active Aging Index (S-AAI) among rural elderly in lower northern Thailand classified by age and gender
Authors: Keeratisiroj Orawan , Kitreerawutiwong Nithra , Mekrungrongwong Sunsanee 
Published: February 2023

AbstractThis study aimed to develop a Self-Active Aging Index (S-AAI) for the rural community of Thailand using the World Health Organization (WHO) framework, and score it according to age and gender. Overall, 1,098 elderly people were randomly selected. The self-reported questionnaires were categorized into three segments: health, participation, and security according to the WHO framework. An exploratory factor analysis was used to determine appropriate components. The S-AAI comprised 28 indicators and 9 factors: (1) mental/subjective health; (2) physical health; (3) health behavior and chronic disease; (4) vision and hearing; (5) oral health; (6) social participation; (7) stability in life; (8) financial stability; and (9) secure living. The overall S-AAI for all components was 0.65, with the index inversely proportional to age, but with no gender differences. The S-AAI is potentially Thailand's first multi-dimensional interactive aging assessment tool with a unique cultural context for rural areas. Although this tool is valid, it requires reliability testing.