bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy efficient green building design utlilising renewable energy and low-carbon development technologies
Authors: Sagar  , Arya Yogendra , Singhal Poonam 
Published: January 2025

The core issue these days is to reduce carbon dioxide (CO2) emission and prevent the hole in the ozone layer. Numerous emerging environmental crises successfully tackled by coordinated global efforts in the past few years. Despite this, the present climate emergency is a much more serious threat than anything we have ever encountered and requires much more action consequently. Today, more attention is paid on green buildings in the society, which will make use of the sustainable and energy-efficient buildings a necessity for future generations. Hence, this paper proposes a novel design model of an energy-efficient residential green building with low carbon emission to maintain the health and enhances the productivity and living standards of inhabitants. Green building technology is utilised to enhance energy efficiency and lower carbon emission. This design considers green, recyclable, and eco-friendly building materials, which are beneficial for human health and comply with relevant Indian standards and building codes. This building design proposes Renewable Energy Sources (RES) integrated with the power grid, although RES powers most of the load of the proposed green building. The suggested green building design shows effective results, i.e., building energy consumption has reduced by 50.54%, total energy consumption cost has reduced by 57.41%, and CO2 emission per month has reduced by 50.54%. In addition, stormwater-harvesting system is proposed to collect 54,322.23 L of rainwater annually, which helps in water conservation and contributes to improve the groundwater level. The proposed solid waste management plan has contributed to the achievement of regional and national Sustainable Development Goals (SDGs). Finally, there are some suggestions to promote the use of green buildings for sustainable development.
Long-Term Efficacy and Safety of Lebrikizumab Is Maintained in Patients With Moderate-to-Severe ​ Atopic Dermatitis: Results Up to 3 Years From ADjoin
Authors: Guttman-Yassky Emma , Irvine Alan , Simpson Eric , Gooderham Melinda , Weidinger Stephan , Spelman Lynda , Silverberg Jonathan , Crane Heidi , Elmaraghy Hany , DeLuca-Carter Louise , Buziqui Piruzeli Maria Lucia , Hu Chaoran , Pierce Evangeline , Agell Helena , Thaçi Diamant 
Published: January 2025

Introduction: We report efficacy and safety of lebrikizumab (LEB) in long-term extension study ADjoin (NCT04392154) following up to 152 Weeks (W) of continuous LEB treatment with/without TCS.
Methods: Patients in ADvocate1&2 who achieved per-protocol response (EASI 75 or IGA 0/1 without rescue) following 16W of LEB treatment were re-randomized 2:2:1 to LEB250mg Q2W, LEB250mg Q4W, or placebo (LEB withdrawal). Patients who completed W52 of ADvocate1&2 could enroll in ADjoin. Patients who completed 16W of ADhere could enroll into ADjoin; per-protocol LEB responders were randomized 2:1 to LEB250mg Q2W or Q4W. Intermittent use of topicals was allowed in ADvocate1&2 W16–52, topicals and short-term systemics were allowed in ADjoin. Data are reported for W16 LEB responders originating from ADvocate1&2 (N=181) and ADhere (N=86) who received LEB250mg Q2W or Q4W in ADjoin. Efficacy outcomes were assessed based on all collected data (as observed analysis) up to W100 of ADjoin (total 152W and 116W of LEB treatment for patients from ADvocate1&2 and ADhere, respectively). Safety was reported from ADjoin enrollment up to the data cut-off April 24, 2024.
Results: In patients from ADvocate1&2, at W152 IGA 0/1 was maintained by 82.9% (34/41; Q2W) and 84.0% (42/50; Q4W) and EASI 75 was maintained by 90.5% (57/63; Q2W) and 94.1% (64/68; Q4W) of patients. In patients from ADhere, at W116 IGA 0/1 was maintained by 86.7% (26/30; Q2W) and 91.7% (11/12; Q4W) and EASI 75 was maintained by 94.9% (37/39; Q2W) and 90.9% (20/22; Q4W) of patients. EASI 90 was reported by 79.4% (50/63; Q2W) and 86.8% (59/68; Q4W) of ADvocate1&2 patients at W152 and 84.6% (33/39; Q2W) and 86.4% (19/22; Q4W) of ADhere patients at W116.
During 100Ws of ADjoin, most adverse events (AE) reported were mild (29.2%, 78/267) or moderate (33.3%, n=89) in severity. Serious AEs were reported by 4.1% (n=11) of patients. There was one death due to natural causes in the ADhere Q2W arm. AEs leading to treatment discontinuation were reported by 2.6% (n=7) of patients.
Conclusion: Efficacy outcomes were maintained long-term, up to 3 years of continuous LEB treatment, in both LEB250mg Q2W and Q4W arms. The safety profile of LEB in ADjoin was consistent with previous LEB studies in patients with moderate-to-severe AD.
Increased angiotensin converting enzyme (ACE2) level is associated with the cardiovascular risk in diabetes
Authors: Naveena Gurramkonda , Shivasekar Meera , Vinodhini V. M. , Nath Dinesh 
Published: January 2025

Objectives:
Increased plasma angiotensin-converting enzyme 2 (ACE2) levels are associated with cardiovascular risk in diabetes and therapeutic targets. ACE2 is an endogenous regulator of the renin-angiotensin system and is important in various cardiovascular diseases (CVDs). This study aimed to investigate the association between increased ACE2 levels and cardiovascular risk in patients with type 2 diabetes mellitus (T2DM), particularly those with CVD.

Materials and Methods:
In this cross-sectional study, subjects were classified into 3 groups. Each Group has 87 individuals. Group I was considered as controls, Group II was considered as diabetes, and Group III was considered as diabetes with heart disease who attended the master health checkup, cardiology and general medicine OP in the tertiary care centre. The serum ACE, ACE2, oxidized-low-density lipoprotein (ox-LDL), and highly sensitive c-reactive were examined using the enzyme-linked immunosorbent assay technique, and the lipid levels were measured using the AU 480 (Auto analyser).

Results:
The study found that mean plasma ACE, ACE2, ACE/ACE2 ratio, ox-LDL, and high-sensitivity-C-reactive protein (hs-CRP) levels were significantly higher in group III than compared to group II and group I (P < 0.001). A significant correlation was observed between ACE2, ACE, ACE/ACE2 ratio, hs-CRP, and ox-LDL in patients with group III. Linear regression analysis showed a strong association of ACE2 with hs-CRP, ox-LDL and ACE.

Conclusion:
The study concludes that increased ACE2 levels may be associated with the risk of CVD in T2DM, especially in those with coronary heart disease. These findings suggest the possibility of independent risk assessment in diabetic patients.
SMARANDACHE ANTI ZERO DIVISORS
Authors: Hassan Rebin M. , Awla Suham H. 
Published: January 2025

In this paper, we study and discuss the concept of Smarandache anti zero divisor (SAZD) element of the ring and the group ring , where is a cyclic group of order generated by . Moreover, we introduce and discuss the concept of SAZD ideal of the ring . Some results related to the given concepts are proved in detail. Accordingly, a Computer Algebra System (GAP) is used to verify the results of this study
Long-term prognosis of adverse cardiovascular events in patients with chronic heart failure depending on the rs1143634 polymorphism of the interleukin-1β gene
Authors: Khazova E. V. 
Published: January 2025

The course and prognosis of chronic heart failure (CHF) are associated with the activation of inflammatory cascades, the severity of which is genetically determined.Aim: To analyze adverse cardiovascular events in patients with chronic heart failure over 5 years depending on the rs1143634 polymorphism of the interleukin-1β gene.Material and Methods. Clinical signs were studied, genotyping was carried out at the polymorphic locus rs1143634 of the IL-1β gene in patients with CHF of ischemic origin (n = 445, average age 66.4 ± 10.4 years). Information on patient outcomes over 5 years was obtained by telephone interview with endpoints: all-cause death, cardiovascular death, fatal and non-fatal cardiovascular events formed a composite endpoint. Time to event was analyzed using the Kaplan-Meier method; hazard ratio – Cox regression. Statistical processing was carried out in the Jamovi, R 4.3.1 programs.Results and conclusions. The occurrence of genotypes of the rs1143634 polymorphism of the IL-1β gene in patients with CHF and the genetic control group did not differ and was commensurate with the theoretically expected Hardy–Weinberg equilibrium. Carriers of the TT genotype were characterized by a high level of inflammation and the development of myocardial infarction at a young age. In patients with CHF of the TT genotype, the risk of death from all causes is 2.85 times higher, achieving the combined endpoint is 3.3 times higher, fatal cerebral stroke is 17.1 times higher compared to CC, 14.9 times higher than compared to ST genotype. In patients with CHF and chronic kidney disease of the TT genotype, the risk of death from cerebral stroke is 29.33 times higher than the CC genotype, and 29.12 times higher for the CT genotype. In patients with CHF in combination with diabetes mellitus, the frequency of hospitalizations due to cardiac decompensation in the TT genotype is higher than in the CC and CT genotypes (χ2 = 6.33, p = 0.042).chronic heart failure; rs1143634 polymorphism of the IL-1β gene; prognosis; cardiovascular complications
An Investigation Towards Resampling Techniques and Classification Algorithms on CM1 NASA PROMISE Dataset for Software Defect Prediction
Authors: Fatwanto Agung , Nur Aslam Muh , Ndugi Rebbecah , Syafrudin Muhammad 
Published: January 2025

Software defect prediction is a practical approach to improving the quality and efficiency of software testing processes. However, establishing robust and trustworthy models for software defect prediction is quite challenging due to the limitation of historical datasets that most developers are capable of collecting. The inherently imbalanced nature of most software defect datasets also posed another problem. Therefore, an insight into how to properly construct software defect prediction models on a small, yet imbalanced, dataset is required. The objective of this study is therefore to provide the required insight by way of investigating and comparing a number of resampling techniques, classification algorithms, and evaluation measurements (metrics) for building software defect prediction models on CM1 NASA PROMISE data as the representation of a small yet unbalanced dataset. This study is comparative descriptive research. It follows a positivist (quantitative) approach. Data were collected through observation towards experiments on four categories of resampling techniques (oversampling, under sampling, ensemble, and combine) combined with three categories of machine learning classification algorithms (traditional, ensemble, and neural network) to predict defective software modules on CM1 NASA PROMISE dataset. Training processes were carried out twice, each of which used the 5-fold cross-validation and the 70% training and 30% testing data splitting (holdout) method. Our result shows that the combined and oversampling techniques provide a positive effect on the performance of the models. In the context of classification models, ensemble-based algorithms, which extend the decision tree classification mechanism such as Random Forest and eXtreme Gradient Boosting, achieved sufficiently good performance for predicting defective software modules. Regarding the evaluation measurements, the combined and rank-based performance metrics yielded modest variance values, which is deemed suitable for evaluating the performance of the models in this context.
Slogan “Pentingnya Menguasai MIPA dan Bahasa Asing” dalam Konsep Pendidikan Yudian Wahyudi
Authors: Shulhan Shulhan , Sodik Hairus , Syarifah Syarifah , Maida Maida 
Published: January 2025

Abstrak: Yudian Wahyudi merupakan salah satu tokoh Islam di Indonesia yang serius mengampanyekan pentingnya umat Islam untuk menguasai MIPA (Matematikan, Ilmu Pengetahuna Alam) dan bahasa asing selain memahami ilmu agama untuk meraih kejayaan dunia dan akhirat. Tulisan ini dimaksudkan untuk mendiskusikan arti penting menguasai MIPA dan bahasa asing dalam pandangan Yudian Wahyudi. Penelitian ini dilaksanakan dengan menggunakan metode kualitatif berbasis library reserch dengan menempatkan teks atau naskah yang mendokumentasikan pemikiriannya sebagai sumber utama. Peneliti menempati posisi kunci dalam megumpulkan data, pengelolahan data, dan interpretasi data. Hasil penelitian ini antara lain. 1. Penyebab kemunduran Islam adalah tereleminasinya ilmu-ilmu terapan yang berbasis penelitian. Umat Islam lebih memilih mendalami ilmu agama dan mengabaikan hal-hal yang berhubungan peningkatan kapasitas keduniaan. 2. Umat Islam di Indoneisa memiliki modal besar sebagai argumentasi logis pentingnya menguasai MIPA dan bahasa asing untuk memperoleh keyaan kembali yaitu populasi masyarakat muslim sangat besar dan besarnya sumber daya alam yang tersedia di Nusantara. 3. Mengambalikan kejayaan Islam dimulai dengan membangkitkan kembali collective consciousness bahwa setiap orang wajib menguasai bahasa asing dan MIPA selain mempu membaca kitab-kitab kuning dan pengamalannya. Tingginya kuantitas umat Islam harus berbanding lurus dengan kualitasnya yang terdistribusi ke dalam beberapa sektor strategis. Hal itu menuntut setiap pribadi memiliki kapasitas dalam satu bidang ilmu terapan yang dapat digunkan untuk berkontribusi dalam pembangunan nasional. Masyarakat muslim memerlukan posisi ideal dalam keagamaan, sosial, ekonomi dan politik serta teknologi tepat guna.
Analisis Reproduksi Makna Isra’ Mi’raj dalam Tafsir Ilmi Kemenag RI Perspektif Hermeneutika Schleiermacher
Authors: Abdulfatah Fikri , Hasyim Muh Fathoni , Razi Fahrur 
Published: January 2025

Penelitian ini menyajikan analisis-deskriptif reproduksi makna ayat Isra’ Mi’raj dalam Tafsir Ilmi Kemenag RI. Melalui pemaparan yang sistematis, penelitian ini menganalisis bagaimana psikologi mufasir dapat mempengaruhi proses reproduksi makna suatu ayat atau lafaz. Dalam perubahan dinamika ilmu pengetahuan dan teknologi, penelitian ini tidak hanya relevan, tetapi juga esensial dalam pelestarian nilai-nilai akidah tentang peristiwa Isra’ Mi’raj. Keunggulan penelitian ini terletak pada dorongan mendalam untuk memahami ragam reproduksi makna ayat atau lafaz Isra’ Mi’raj melalui perspektif hermeneutika Schleiermacher. Hasil penelitian ini menghadirkan pandangan yang lebih tajam dan pemahaman atas ragam konteks yang mempengaruhi reproduksi makna pada ayat Isra’ Mi’raj. Harapannya, penelitian ini dapat menyajikan suatu pembahasan yang sistematis dan terstruktur sehingga keragaman makna Isra’ Mi’raj yang disajikan dalam Tafsir Ilmi Kemenag RI dapat dipahami dengan lebih baik.
CRITICAL ANALYSIS OF THE IMPLEMENTATION OF THE MARKET DAY PROGRAM IN FOSTERING THE ENTREPRENEURIAL SPIRIT AMONG STUDENTS IN ELEMENTARY SCHOOL
Authors: Iriyani Muji , Andriani Ana 
Published: January 2025

Education is one way to build an entrepreneurial spirit. One of the entrepreneurship programs is the market day program. The purpose of this study is to analyze the implementation of the market day program in fostering the entrepreneurial spirit of students at SD Negeri 1 Banjarkulon Banjarnegara. This research method uses a descriptive qualitative approach with a case study method. Data collection techniques using observation, interviews and documentation. The sources of informants used are students, teachers managing the market day program and parents of students The results of this study indicate that with the market day program most students have an entrepreneurial spirit such as self-confidence, creativity in making products, enthusiasm in selling, having a leadership spirit and taking risks. The conclusion of this study is that the implementation of the market day program at SD Negeri 1 Banjarkulon Banjarnegara can foster the entrepreneurial spirit of students well.
Analysis of Hadith on "Poverty" and Its Correlation with the Hadith of "Production" (Study of the Thought Ali Mustafa Yaqub)
Authors: Fatah Hairil 
Published: January 2025

Ali Mustafa Yaqub said that the hadith "poverty almost gives rise to disbelief" is weak or wrong. However, there is a hadith of the Prophet Saw., which asks to be kept away from poverty. Because poverty causes impacts such as crime, violence, theft, or loss of (religious) belief. So, hadiths about poverty essentially have the message that being productive is mandatory, just as the Prophet Saw., recommended production in managing land. The aim of this research is to find out Ali Mustafa Yaqub's thoughts about hadiths that talk about poverty and their correlation with production hadiths: farming. The method used is qualitative with the type of library research with primary and secondary sources from various literature. The results of the research show that Ali Mustafa Yaqub's thoughts about the hadith "poverty almost makes disbelief" are weak or false, because it was narrated by Yazid bin Aban al-Raqqasyi who was accused of lying. Also, the Prophet SAW., asked to be kept away from poverty, This means that poverty will have a negative social and religious impact, does not claim (demands) the possibility of impacting one's faith. So that the hadith about poverty is understood not as a matter of whether it is true or not, but the meaning behind it is a recommendation to actively innovate, creativity, and productive in any way, including production, managing land. So that Muslims become an economically strong people, and are free from the shackles of poverty.
STABILITY ANALYSIS OF THE SIQR MODEL OF DIPHTHERIA DISEASE SPREAD AND MIGRATION IMPACT
Authors: Soleh Mohammad , Nazvira Mutia , Wartono Wartono , Safitri Elfira , Sriningsih Riry 
Published: January 2025

Diphtheria is an acute disease that affects the upper respiratory tract caused by Corynebacterium diphtheriae, which can also affect the skin, eyes, and other organs. This article analyzes the stability of the SIQR model of diphtheria disease spread in Mandau District by considering the migration factor. The SIQR model is a development of the SIR model by incorporating the quarantine process as an alternative to reduce morbidity. The purpose of this study is to see the effect of migration on the spread of diphtheria disease in Mandau District through mathematical model simulation. We calculated the disease-free and endemic equilibrium points and the basic reproduction number ( ) of the model. Model parameters were obtained using data from BPS Bengkalis Regency and UPTD Puskesmas Mandau. The calculation resulted in one disease-free equilibrium point and one endemic equilibrium point. If < 1, then the disease-free equilibrium point is asymptotically stable, and if > 1, then the endemic equilibrium point is also asymptotically stable. Based on the results of the data analysis, the value of. This value is less than 1, so the equilibrium point obtained is a disease-free and asymptotically stable equilibrium point. This means that the population will be free from diphtheria and the level of migration affects the presence of diphtheria disease in Mandau District.
DEVELOPMENT OF NONPARAMETRIC PATH FUNCTION USING HYBRID TRUNCATED SPLINE AND KERNEL FOR MODELING WASTE-TO-ECONOMIC VALUE BEHAVIOR
Authors: Rohma Usriatur , Fernandes Adji Achmad Rinaldo , Astutik Suci , Solimun Solimun 
Published: January 2025

Waste management remains a challenge, including in Batu City, East Java, Indonesia. Rapid population growth and economic activities in the city have resulted in a substantial increase in waste volume. One of the key factors in solving waste problems is the mindset of the community towards waste management. The application of statistical analysis methods can be an effective approach to solving problems related to waste management from an economic point of view. Nonparametric path analysis is a statistical method that does not rely on the assumption that the curve is known. Nonparametric path analysis is performed if the data does not fulfill the linearity assumption. This study aims to determine the best nonparametric path function with a hybrid truncated spline and kernel approach among EV values of 0.5; 0.8; and 1. In addition, this study also aims to test the significance of the best path function obtained. The data used in this study are timer data obtained from the Featured Basic Research Grant. The results showed that the best model of hybrid truncated spline and kernel nonparametric path analysis is a hybrid model of truncated spline nonparametric path of linear polynomial degree 1 knot and kernel triangle nonparametric path at EV 0.5. In addition, the significance of the best nonparametric truncated spline and kernel hybrid path function estimation using jackknife resampling shows that all exogenous variables have a significant effect on endogenous variables as evidenced by a p-value smaller than (0.05).
THE LOCATING CHROMATIC NUMBER OF CHAIN(A,4,n) GRAPH
Authors: Welyyanti Des , Abel Latifa Azhar , Yulianti Lyra 
Published: January 2025

Let be a connected graph with a vertex coloringsuch that two adjacent vertices have different colors. We denote an ordered partition where is a color class with color-, consisting of vertices given color , for . The color code of a vertex in is a -vector: . where is the distance between a vertex in and for . If every two vertices and in have different color codes, , then is called the locating -coloring of . The minimum number of colors k needed in this coloring is defined as the locating chromatic number, denoted by . This paper determines the locating chromatic number of chain graph and the induction of two graphs . Graph is a cyclic graph , which is the identification of , for n>2.
A MATHEMATICAL APPROACH TO INVESTMENT WITH CHARGE ON BALANCE AND VOLUNTARY CONTRIBUTIONS UNDER WEIBULL MORTALITY FORCE FUNCTION
Authors: Akpanibah Edikan Edem , Benneth Peter , Esabai Ase Matthias 
Published: January 2025

One of the many challenges encountered by most pension fund administrators (PFAs) in the Defined Contribution (DC) pension plan is the determination of a sustainable and suitable investment plan for their members under mortality risk. To achieve this, there is need to develop an optimal portfolio which considers the volatility of the stock market price consisting of one risk-free asset and a risky asset which follows the Heston volatility model (HVM). Also, the portfolio considers additional voluntary contributions (AVC) by members, tax on the stock market price, charge on balance (CB), and the mortality risk of the pension scheme members (PSM) modeled by the Weibull mortality force function. Furthermore, an optimization problem is established from the extended Hamilton Jacobi Bellman (EHJB) equation using variational method. By applying the variable separation technique and mean variance utility, the optimal control strategy (OCS) and the efficient frontier are obtained. Finally, some numerical simulations are presented to study the behavior of the OCS with respect to some sensitive parameters. It was discovered that the composition of the OCS depends on the instantaneous volatility, tax on investment, AVC, risk aversion coefficient (RAC), CB and the correlation coefficient. Hence, the understanding of the behaviour these parameters are very crucial in the determination of OCS.