bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravascular ultrasound-guided dissection recanalization in a patient with ST-segment elevation myocardial infarction: a case report
Authors: Sangen Hideto , Wakita Masaki , Toguchi Riku , Tanaka Kunio 
Published: April 2023

Abstract

Background
In primary percutaneous coronary intervention (PCI) for acute myocardial infarction, we occasionally experience challenging cases where conventional guidewires cannot pass through the lesion. In such cases, if the use of a tapered guidewire or polymer jacket guidewire is also unsuccessful, coronary artery bypass surgery becomes inevitable. Therefore, other methods to enable revascularization in a reliable and timely manner are desirable.

Case summary
We present the first case of intravenous ultrasound (IVUS)-guided tip detection (TD)-antegrade dissection re-entry (ADR) in a 73-year-old man who suffered ST-segment elevation myocardial infarction (STEMI). The patient had a total thrombotic occlusion of the right coronary artery and stenotic lesion of the left anterior descending artery. Primary PCI was unsuccessful and IVUS-guided rewiring using a chronic total occlusion (CTO) wire failed due to thrombus attenuation. However, IVUS imaging revealed the presence of intimal and subintimal space, which led us to perform IVUS-guided TD-ADR using Conquest Pro 12 ST (Asahi Intecc). Using the TD method, we were successful in swiftly puncturing the true lumen wall, and a stent was implanted following successful re-entry. Final angiography showed the establishment of Thrombolysis in Myocardial Infraction-3 flow and resolution of ST-segment elevation.

Discussion
IVUS-guided TD enables accurate puncture in an ADR procedure, enabling successful recanalization in a relatively short time. Thus, IVUS-guided TD-ADR is a reliable option for revascularization in STEMI cases wherein the guidewire fails to pass the occlusion using conventional techniques.
Primary cardiac lymphoma: a case report
Authors: Ellen Saghie , Emma Higgisson 
Published: April 2023

Abstract

Background
Primary cardiac lymphoma is an extremely rare malignancy involving the heart and pericardium. It is a disease that most commonly effects the right atrium and right ventricle. Left untreated it carries a very poor prognosis. Recent advancements in therapy including early recognition and initiation of chemotherapy has led to improved survival.

Case summary
A 78 year old female presented with weight loss, abdominal pain and distension. An ultrasound abdomen pre admission showed abdominal ascites. An echocardiogram performed during admission showed a large pericardial effusion with asymmetrical increase in left ventricular wall thickness and a new left atrial mass. Pericardial fluid analysis led to the diagnosis of diffuse large B cell non-Hodgkin's lymphoma. Positron Emission Tomography CT (PET-CT) shows avid fluorodeoxyglucose (FDG) uptake in cardiac muscle. Prompt treatment was initiated with a chemotherapy regimen involving Rituximab, Cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). An echocardiogram 3 months post initiation of treatment showed resolution of the pericardial effusion and left atrial mass as well as an improvement in left ventricular wall thickness. A PET-CT following completion of treatment showed complete metabolic response.

Discussion
The diagnosis of primary cardiac lymphoma is uncommon and the presence of left rather than right heart involvement is rarer still. Multimodality imaging is key in diagnosis. Early recognition and treatment is vital in improving associated morbidity and mortality.
Genetic variant in the BRAF gene compatible with Noonan spectrum disorders in an adult Fontan patient with refractory protein losing enteropathy: a follow-up report
Authors: Nederend Marieke , Stoger J Lauran , Egorova Anastasia D , Barge-Schaapveld Daniela Q C M , Jongbloed Monique R M 
Published: April 2023

Abstract

Background
Patients with a univentricular heart form a morphological heterogenous group of patients at the most severe end of the congenital heart disease (CHD) spectrum. Over the past decades, more awareness and knowledge has been raised on the genetic contributions to CHD. To date, only a limited number of genes have been identified in the hypoplastic heart, mainly in left-sided hypoplasia. There is still much more to be elucidated in this field.

Case summary
Here, we present a follow-up report of a case of an adult patient after Fontan palliation, born with a.o. tricuspid atresia with hypoplastic right ventricle and pulmonary stenosis. This patient encountered a myriad of late sequalae involving multiple organ systems during the course of his young adult life, including refractory protein losing enteropathy (PLE). Concomitant extracardiac anomalies, in addition to the complex CHD and its complications, prompted for genetic evaluation. Whole exome sequencing showed a variant of uncertain significance in the BRAF gene [NM_004333.4:c.1897T &gt; C p.(Tyr633His)], associated with Noonan spectrum disorders, that is also infamous for lymphoedema and PLE. The variant regards an evolutionarily highly conserved amino acid and is assumed pathogenic according to all prediction programmes. The mutation was most likely de novo.

Discussion
Genetic screening can provide new insights in the complex and varied phenotype of the (adult) Fontan patient and in the myriad of complications encountered. Adult CHD cardiologists should be aware of genetic syndromes underlying a CHD, concomitant extracardiac anomalies, and a complex clinical course with a broad spectrum of late sequelae.
Precision Medicine in Pancreatitis: The Future of Acute Pancreatitis Care
Authors: Garami Andras , Hegyi Peter 
Published: April 2023

Abstract
Acute pancreatitis (AP) continues to present a substantial burden to patients and healthcare personnel. Despite its occasionally severe progression and high mortality rate, there is no specific therapy that could be routinely applied in patients with AP. Here, we review treatment possibilities in AP, describe how the treatment approaches have changed in pancreatic cancer as an analogy, and point out potential causes for the failure of clinical trials on AP. We highlight that instead of attempting to discover generalized treatment options that could be used in any AP patient, it is time for a paradigm shift in the treatment of AP, which would help to focus more on individual patients or specific patient subpopulations when designing clinical trials and therapeutic approaches (similarly as in pancreatic cancer). Since the recruitment of specific patient subpopulations with AP could take excessive time if clinical centers work separately, the development of precision medicine in AP would require to establish an expert committee, eg, Pancreatitis Precision Medicine Interest Group, which could organize and coordinate the activities of the joined centers. With the joined forces of expert clinicians and leading centers, a new era could start in the treatment of AP, in which personalized treatment options could be discovered and introduced to efficiently reduce the burden of the disease on patients and healthcare workers.
The sweet side of sex as a biological variable
Authors: Hunter Carmanah D , Morris Kaylee M , Derksen Tahlia , Willis Lisa M 
Published: April 2023

Abstract
Glycobiology as a field holds enormous potential for understanding human health and disease. However, few glycobiology studies adequately address the issue of sex differences in biology, which severely limits the conclusions that can be drawn. Numerous CAZymes, lectins, and other carbohydrate-associated molecules have the potential to be differentially expressed and regulated with sex, leading to differences in O-GlcNAc, N-glycan branching, fucosylation, sialylation, and proteoglycan structure, among others. Expression of proteins involved in glycosylation is influenced through hormones, miRNA, and gene dosage effects. In this review, we discuss the benefits of incorporating sex-based analysis in glycobiology research and the potential drivers of sex differences. We highlight examples of where incorporation of sex-based analysis has led to insights into glycobiology. Finally, we offer suggestions for how to proceed moving forward, even if the experiments are already complete. Properly incorporating sex based analyses into projects will substantially improve the accuracy and reproducibility of studies as well as accelerate the rate of discovery in the glycosciences.
Fertility preservation in women with benign gynaecological conditions
Authors: Santulli Pietro , Blockeel Christophe , Bourdon Mathilde , Coticchio Giovanni , Campbell Alison , De Vos Michel , Macklon Kirsten Tryde , Pinborg Anja , Garcia-Velasco Juan A 
Published: April 2023

Abstract
Although a wealth of data has been published regarding fertility preservation (FP) in women with malignant diseases who receive gonadotoxic treatment, the role of FP in non-malignant conditions has been studied to a much lesser extent. These include benign haematological, autoimmune, and genetic disorders, as well as a multitude of benign gynaecological conditions (BGCs) that may compromise ovarian reserve and/or reproductive potential due to pathogenic mechanisms or as a result of medical or surgical treatments. Alongside accumulating data that document the reproductive potential of cryopreserved oocytes and ovarian tissue, there is potential interest in FP for women with BGCs at risk of infertility; however, there are currently insufficient data about FP in women with BGCs to develop guidelines for clinical practice. The purpose of this article is to appraise the available evidence regarding FP for BGC and discuss potential strategies for FP based on estimated ovarian impairment and on short-term and long-term reproductive goals of patients. Cost-effectiveness considerations and patients’ perspectives will also be discussed.
Can Increasing Awareness of Gender Gaps in International Relations Help Close Them? Evidence from a Scholar Ranking Experiment
Authors: Jackson Emily B , Maliniak Daniel , Parajon Eric , Peterson Susan , Powers Ryan , Tierney Michael J 
Published: April 2023

AbstractWe report the results of a survey of international relations (IR) scholars on the use of an increasingly common policy designed to close recognition gaps in IR: gender balance in citation (GBC) statements. GBC statements remind and encourage authors submitting work to peer-reviewed outlets to consider the gender balance among the works they cite. We find that these policies enjoyed wide support among IR scholars in our sample countries soon after journals began instituting the policies, but women were more supportive than men of the policies. We also report the results of a question-order experiment that allows us to study how raising awareness of gender gaps in the IR discipline affects the proportion of women that scholars list among the most influential IR scholars in the last 20 years. The effects of exposure to the gender treatment vary, however, by respondents’ gender and whether respondents teach in the United States. The treatment effects were much larger for women than for men in the United States, but the reverse was true outside the United States.
T2Candida assay: diagnostic performance and impact on antifungal prescribing
Authors: Patrocínio de Jesus Rita , Houston Hamish , Schutte Annemiek H J , Morris-Jones Stephen , Stone Neil , Gorton Rebecca , Pollara Gabriele 
Published: April 2023

AbstractObjectivesTo assess the performance of T2Candida for the diagnosis of invasive candidiasis (IC) against gold standards of candidaemia or consensus IC definitions, and to evaluate the impact of T2Candida on antifungal drug prescribing.MethodsA retrospective review was undertaken of all T2Candida (T2MR technology, T2 Biosystems) performed from October 2020 to February 2022. T2Candida performance was evaluated against confirmed candidaemia or against proven/probable IC within 48 hours of T2Candida, and its impact on antifungal drug prescriptions.ResultsT2Candida was performed in 61 patients, with 6 (9.8%) positive results. Diagnostic performance of T2Candida against candidaemia had a specificity of 85.7% and negative predictive value (NPV) of 96.8%. When comparing T2Candida results with consensus definitions of IC, the specificity and NPV of T2Candida was respectively 90% (54/60) and 98.2% (54/55) for proven IC, and 91.4% (53/58) and 96.4% (53/55) for proven/probable IC. Antifungals were initiated in three of six patients (50%) with a positive T2Candida result. Thirty-three patients were receiving empirical antifungals at the time of T2Candida testing, and a negative result prompted cessation of antifungals in 11 (33%) patients, compared with 6 (25%) antifungal prescriptions stopped following negative beta-d-glucan (BDG) testing in a control population (n = 24).ConclusionsT2Candida shows high specificity and NPV compared with evidence of Candida bloodstream infection or consensus definitions for invasive Candida infection, and may play an adjunctive role as a stewardship tool to limit unnecessary antifungal prescriptions.
Association between piperacillin/tazobactam MIC and survival among hospitalized patients with Enterobacterales infections: retrospective cohort analysis of electronic health records from 161 US hospitals
Authors: Strich Jeffrey R , Lawandi Alexander , Warner Sarah , Demirkale Cumhur Y , Sarzynski Sadia , Babiker Ahmed , Dekker John P , Kadri Sameer S 
Published: April 2023

AbstractIntroductionA recent randomized trial has suggested an increased risk of mortality for ceftriaxone-non-susceptible Enterobacterales infections treated with piperacillin/tazobactam compared with meropenem despite MICs within the susceptible range.MethodsWe conducted a retrospective cohort study of clinical encounters within the Cerner Health Facts database to identify all encounters between 2001 and 2017 in which Enterobacterales infections were treated empirically with piperacillin/tazobactam and for which MICs to the drug were available. Multivariate regression analysis was performed to enable partitioning of MICs into discrete strata based on statistically significant difference in mortality risk.ResultsDuring the study period, 10 101 inpatient encounters were identified meeting inclusion criteria. The crude in-hospital mortality for the entire cohort was 16.5%. Partitioning analysis identified a breakpoint of ≤16/4 mg/L that dichotomized encounters into lower versus higher mortality risk strata in the primary cohort of overall infections. This finding persisted in sequentially granular subsets where specific MICs ≤8/4 mg/L were reported (in lieu of ranges) as well as in the high-reliability subset with bloodstream infections. A higher clinical breakpoint of ≥128/4 mg/L dichotomized encounters with respiratory tract infection. No breakpoint was identified when restricting to encounters with urinary tract infections, ICU admits or upon restricting analysis to encounters with ceftriaxone-resistant isolates.ConclusionsClinical data suggest improved outcomes when piperacillin/tazobactam is prescribed for Enterobacterales infections with an MIC of ≤16/4 mg/L compared with ≥32/4 mg/L.
A Review of Regulations, Terminology, and Practical Approaches to Reportable Range Verification
Authors: Xiao Yi , Chambliss Allison B 
Published: April 2023

Abstract

Background
In the United States, federal regulations under CLIA ‘88 require reportable range verification of quantitative assays used for clinical purposes. Some accreditation agencies and other standards development organizations have their own additional requirements, recommendations, and/or terminologies relating to reportable range verification, leading to varying practices among clinical laboratories.

Content
Requirements and recommendations related to reportable range or analytical measurement range verification from different organizations are reviewed and compared. Optimal approaches to materials selection, data analysis, and troubleshooting are collated.

Summary
This review clarifies key concepts and outlines various practical approaches to reportable range verification.
Evaluation of an approach to clinical decision support for preventing inpatient falls: a pragmatic trial
Authors: Cho Insook , Kim MiSoon , Song Mi Ra , Dykes Patricia C 
Published: April 2023

AbstractObjectivesTo assess whether a fall-prevention clinical decision support (CDS) approach using electronic analytics that stimulates risk-targeted interventions is associated with reduced rates of falls and injurious falls.Materials and MethodsThe CDS intervention included a machine-learning prediction algorithm, individual risk-factor identification, and guideline-based prevention recommendations. After a 5-month plan-do-study-act quality improvement initiative, the CDS intervention was implemented at an academic tertiary hospital and compared with the usual care using a pretest (lasting 24 months and involving 23 498 patients) and posttest (lasting 13 months and involving 17 341 patients) design in six nursing units. Primary and secondary outcomes were the rates of falls and injurious falls per 1000 hospital days, respectively. Outcome measurements were tested using a priori Poisson regression and adjusted with patient-level covariates. Subgroup analyses were conducted according to age.ResultsThe age distribution, sex, hospital and unit lengths of stay, number of secondary diagnoses, fall history, condition at admission, and overall fall rate per 1000 hospital days did not differ significantly between the intervention and control periods before (1.88 vs 2.05, respectively, P = .1764) or after adjusting for demographics. The injurious-falls rate per 1000 hospital days decreased significantly before (0.68 vs 0.45, P = .0171) and after (rate difference = –0.64, P = .0212) adjusting for demographics. The differences in injury rates were greater among patients aged at least 65 years.ConclusionsThis study suggests that a well-designed CDS intervention employing electronic analytics was associated with a decrease in fall-related injuries. The benefits from this intervention were greater in elderly patients aged at least 65 years.Trial RegistrationThis study was conducted as part of a more extensive study registered with the Clinical Research Information Service (CRIS) (KCT0005378).
Relocation Issues of Released and Acquitted at International Criminal Courts and Tribunals
Authors: Lecolle Cécile 
Published: April 2023

Abstract
The study of the treatment of released and acquitted persons by international courts and tribunals (ICTs) has been one of the most neglected aspects of international criminal justice. The system rests on the cooperation of states with the ICTs. However, this cooperation when it exists, often ceases when the trial has ended. Regarding the objective of delivering justice, states appear to have either forgotten or refused to accept that both acquittals and the eventual release of convicted individuals are part of the process of criminal justice. Even states committed to international justice have denied protection against extradition to unsafe countries for acquitted and released persons, or declined to become host countries, grant asylum requests or take any steps to offer these former defendants and convicted persons a dignified life. This article explores the international legal frameworks applicable to the relocation of persons released or acquitted by ICTs. It specifically looks into the cases of the ad hoc tribunals and the International Criminal Court (ICC), the states parties’ general obligation under the statutes and rules to cooperate with the ICTs, and relevant principles of refugee law. The article explores some of the most recent issues relating to relocation that have shaken international criminal justice. At the International Criminal Tribunal for Rwanda, the recent striking failure to obtain the relocation of nine acquitted and released persons is examined as an emblematic and appalling example of the violation of these persons’ fundamental human rights, and the refusal of the international community to pursue justice in all its aspects. At the ICC, important issues of relocation have already arisen for acquitted and released persons, and the Court will urgently need agreements in this area. Importantly, it is necessary to recognize that, to protect the rights of these former defendants, the practical work of defence lawyers continues long after their clients’ release.
Time-to-positivity in bloodstream infection for Candida species as a prognostic marker for mortality
Authors: Keighley Caitlin , Pope Alun L , Marriott Debbie , Chen Sharon C-A , Slavin Monica A ,   Australia and New Zealand Mycoses Interest Group, Arthur Ian , Baird Rob , Bak Narin , Blyth Christopher , Botes Jeannie , Chapman Belinda , Cheong Elaine , Cooley Louise , Daveson Kathryn , George Rob , Goeman Emma , Hajkowicz Krispin , Halliday Catriona , Heath Christopher H , Hofmeyr Ann , Kalukottege Pankaja , Kesson Alison , Kennedy Karina , Kidd Sarah , Korman Tony M , Leung Michael , Liu Eunice , Macesic Nenad , McDonald Kyle , McMullan Brendan , Morrissey Orla , Pendle Stella , Robson Jenny , Sorrell Tania , Underwood Neil , van Hal Sebastian , Weeks Kerry , Wilson Heather 
Published: April 2023

Abstract
Time-to-positivity (TTP) may assist in predicting the outcome of candidaemia. We analysed a candidaemia dataset collected prospectively in Australia over 1 year (2014–2015). TTP was defined as the period from blood culture sampling to the blood culture flagging positive. Of 415 candidaemia episodes, overall, 30-day mortality was 29% (120/415); mortality with Candida albicans was 35% (59/169), C. glabrata complex, 37% (43/115), C. tropicalis, 43% (10/23), Pichia kudriavzevii 25% (3/12), and C. parapsilosis complex 7% (5/71). Each day of increased TTP multiplied the odds ratio (OR) of survival at 30 days by a factor of 1.32 [95% confidence interval (CI) 1.06–1.69]. Shorter TTP was associated with increased mortality, with 1-day TTP associated with 30-day mortality 37% (41/112) (95%CI: 28%–46%) and 5-day TTP 11% (2/18) (95%CI: 2%–36%).
Capture of stars into gaseous discs around massive black holes: alignment, circularization, and growth
Authors: Generozov A , Perets H B 
Published: April 2023

ABSTRACT
The majority of massive black holes (MBHs) likely hosted gas discs during their lifetimes. These could either be long-lived active galactic nuclei (AGN) discs, or shorter-lived discs formed following singular gas infall events, as was likely the case in our own Galactic Centre. Stars and compact objects in such environments are therefore expected to interact with the gaseous disc as they go through it, and potentially become aligned and fully embedded within it. The interactions of embedded stars with the gas could give rise to a plethora of physical processes affecting the stars, including growth through accretion of gas, migration in the disc, stellar captures, and mergers with other stars. The impact of such processes strongly depends on the population of stars that eventually align with the disc and become embedded in it. Here we make use of analytic tools to analyze the alignment process, accounting for both geometric drag and gas dynamical friction. We find that up to $\sim \! 50~{{\ \rm per\ cent}}$ of main sequence stars and stellar mass black holes in the central 0.1 pc can align with AGN disc in the Galactic Centre and similar galactic nuclei. The orbits of aligned stars are typically circularized and are prograde with respect to the AGN disc. Furthermore, alignment and accretion are intimately linked, and the capture of stars by an AGN disc can potentially explain the origin of the young stellar disc in the Galactic Centre with a top-heavy mass function, even without the need for a star-formation event.