bluuebunny/crossref_metadata_2025_split huggingface dataset:
A human, allogeneic cortical bone screw for distal interphalangeal joint (DIP) arthrodesis: a retrospective cohort study with at least 10 months follow-up
Authors: Krasny Christian , Radda Christian , Polke Ralf , Schallmayer Daniel , Borchert Gudrun H. , Albrecht Christian 
Published: February 2023

Abstract
Introduction
The prime requisites of a good digital arthrodesis are a painless and stable union in a proper position. Arthrodesis of the distal interphalangeal joint of the fingers is not without potential complications including nonunion, malunion, and deep tissue infections. The Shark Screw® is a human, cortical bone allograft for osteosynthesis and an alternative to metal or bioabsorbable devices in orthopedics and trauma surgery. The primary hypothesis is that the fusion and complication rate, using the Shark Screw®, is at least similar to those reported in the literature, using metal or bioabsorbable screws.

Material and methods
This retrospective cohort study analyzes the fusion and complication rate and the patient satisfaction of distal interphalangeal joint arthrodesis of 27 fingers with the human allogeneic cortical bone screw. Complications, Disabilities of Arm, Shoulder, and Hand Questionnaire (Quick-DASH) score and Michigan Hand Outcomes Questionnaire (MHQ) score, grip and pinch strength and fusion angle were investigated.

Results
The mean follow-up was 23 months. At 6 weeks after surgery, fusion was obtained for all fingers. There was no surgical complication that required revision surgery. An average fusion angle of 13.6° ± 10.7° was measured. VAS pain score decreased significantly from 6.9 before surgery to 0.14 after surgery. The Quick-DASH score decreased from 10.7 to 7.8. The MHQ score improved in all sub-scores.

Conclusion
The complication rates, using the Shark Screw® for DIP joint arthrodesis, are lower compared to the results reported in the literature for other surgical techniques. Complications related to the human allograft cortical bone screw itself were not observed. The bone screw is completely remodeled into the host bone and further hardware removal is not necessary.

Level of evidence
IV.
Impact of the COVID-19 pandemic on the epidemiology of severe burns
Authors: Christ Alexandra , Staud Clement J. , Wielscher Matthias , Resch Annika , Teufelsbauer Maryana , Radtke Christine 
Published: February 2023

Summary
Introduction
Currently, very little detailed information on the epidemiological distribution and specificities of severely burned patients during the coronavirus disease 2019 (COVID-19) pandemic is available. This retrospective study aims to describe and compare this specific patient population based on 114 patients who were treated between March 2019 and March 2021 at the Center for Severe Burn Injuries at the Medical University of Vienna.

Methods
To answer the research questions, a retrospective cohort study has been conducted over a period of 24 months, starting in March 2019 and ending in March 2021. To evaluate the epidemiological differences, the patients were divided into 2 observation periods of 12 months each.

Results
In the period from 12 March 2020 to 11 March 2021, a total of 62 patients were admitted to the Center for Severe Burn Injuries. In comparison, only 52 patients were admitted in the same period of the previous year, which corresponds to an increase of 19.2%. In addition, it was noted that during the 2019–2020 observation period, 27% of patients were female and 73% male, whereas during the pandemic the gender distribution was 42% female and only 58% male. During the pre-pandemic observational period, 13 out of 52 patients admitted died (25%), whereas during the pandemic, 17 out of 62 patients succumbed to their injuries (27%).

Conclusion
Although the severity of the COVID-19 pandemic seems to be decreasing, especially due to the increasing availability of vaccines, there is a need for more data on the impact of the crisis on severely burned patients. In contrast to the current literature, we have seen a greater number of inpatient admissions to the Center for Severe Burn Injuries, as well as significant differences in gender distribution. Our data also suggest that the circumstances of the pandemic have no influence on the likelihood of survival for patients with severe burns.
The role of insects in promoting the health and gut status of poultry
Authors: Malematja E. , Manyelo T.G. , Sebola N.A. , Mabelebele M. 
Published: February 2023

AbstractThe structure and functionality of digestive system and gastrointestinal microbiota composition play a crucial role in the development of the gastrointestinal tract and gut morphology. A well-developed gastrointestinal tract will have a proper balanced proportion between the beneficial and harmful microbes; therefore, this balance will promote nutrient utilization and stimulate the development of immune system. The gut microbiota living in an animal’s gastrointestinal tract can be modulated through the feeding of prebiotic or probiotic compounds which have effects on the animal’s humoral immunity, hence improving the nutrient utilization and thus improving growth performance and the overall health condition of the animal. Therefore, this review aimed to provide a comprehensive understanding and recent reports on the role of insect meal in poultry feed aimed at improving health condition and gut status in poultry production. A literature search was performed with an electronic database of Directory of Open Access Journals (DOAJ), Research gate, Web of Science, Science Direct, Google Scholar, and PubMed. In addition, recently published manuscripts were selected, and the citations included in articles from the databases were used to search for other relevant articles. The studies were evaluated, and the level of evidence varied with insect types, inclusion levels, and the supplementing method. Extensive research has shown that insects can be safely used in poultry feeds to modulate the development of digestive and immune system without compromising the production parameters and the quality of the produce. Insects can be directly fed to chickens or can be processed into insect meals and supplemented in the diet. Nonetheless, most literatures done on the effects of insect meal are focused commercial chicken breeds and little attention is given to other poultry species; therefore, more studies are recommended to ascertain these findings.
Energy dissipation in viscoelastic Bessel media
Authors: Colombaro Ivano , Giusti Andrea , Mentrelli Andrea 
Published: February 2023

AbstractWe investigate the specific attenuation factor for the Bessel models of viscoelasticity. We find that the quality factor for this class can be expressed in terms of Kelvin functions and that its asymptotic behaviours confirm the analytical results found in previous studies for the rheological properties of these models.
The Normative Value of Making a Positive Contribution–Benefiting Others as a Core Dimension of Meaningful Work
Authors: Martela Frank 
Published: February 2023

AbstractMost normative accounts of meaningful work have focused on the value of autonomy and capability for self-development. Here, I will propose that contribution–having a positive impact on others through one’s work–is another central dimension of meaningful work. Being able to contribute through one’s work should be recognized as one of the key axiological values that work can serve, providing one independent justification for why work is valuable and worth doing. Conversely, I argue that having to do work that has no positive impact, or where one is separated from such impact, is an underrecognized type of alienation. Such alienation as pointlessness can be as harmful as the more recognized types of alienation such as powerlessness. Recognizing contribution as a core dimension of meaningful work is compatible with both subjectivist and objectivist accounts of meaningfulness, but I come to support a mixed view where the subjective sense of contributing must be sufficiently warranted by the facts of the situation. Recognizing the inescapable interest humans have for being able to contribute and engage in work that is not pointless has implications for the duties societies, organizations, and individuals have as regards ensuring that work conducted includes a recognizable positive impact. Along with autonomy and self-development, contribution should thus be seen as an independent axiological value that work can serve, its frustration being associated with a specific type of alienation, and it itself playing a key role in what makes work valuable and meaningful.
Attenuation Sensitivity Kernel Analysis in Viscoelastic Full-Waveform Inversion Based on the Generalized Standard Linear Solid Rheology
Authors: Song Jianyong , Cao Hong , Pan Wenyong , Yang Zhifang , Li Hongbing , Lu Minghui , Hu Xinhai 
Published: February 2023

AbstractObtaining accurate subsurface Q (quality factor) models using full-waveform inversion (FWI) methods remains a challenging task. The forward modeling problem of viscoelastic wave propagation can be solved by superimposing N rheological bodies of Maxwell or Zener type with generalized standard linear solid rheology. However, different approaches were proposed to calculate the attenuation sensitivity kernels in viscoelastic FWI. This study reviews and compares previous theories for constructing the viscoelastic sensitivity kernels. Furthermore, we derive the viscoelastic sensitivity kernels directly following the adjoint-state (or Lagrangian multiplier) method. Compared to previous approaches, we reveal that the Q sensitivity kernels can be calculated with adjoint memory strain variables. In the numerical experiments, different methods are used to calculate the viscoelastic sensitivity kernels for comparison. We have found that when simultaneously inverting for velocity and Q models, these methods can provide inversion results of comparable quality. However, in the event of inaccurate velocity structures, the Q sensitivity kernels calculated with memory strain variables can resolve the Q anomalies more clearly, while suffering from fewer parameter trade-offs.
The Well-being and Support Needs of Australian Caregivers of Neurodiverse Children
Authors: D’Arcy Emily , Burnett Tayah , Capstick Emily , Elder Catherine , Slee Olivia , Girdler Sonya , scott Melissa , Milbourn Ben 
Published: February 2023

AbstractCaregivers of children with neurodiverse needs are known to experience challenges and hardship due to the increased needs of the child and the lack of support available. This study aimed to explore the support needs and well-being of caregivers of children with neurodiverse needs in Australia. Sixty-six caregivers participated in an online survey asking questions about support needs. The results highlighted five main themes that caregivers commonly experienced including: barriers to community engagement, impact on close relationships, negative impact on mental health and identity, financial hardship, and identified support needs. Findings identified multiple unmet needs existing amongst caregivers and further emphasises the importance of addressing these needs to improve the quality of life of caregivers of children with neurodiverse needs.
Fluoride ion adsorption isotherms, kinetics, and thermodynamics on iron(III) oxyhydroxide powders containing cellulose nanofibrils
Authors: Umehara Masahiro , Kumamoto Yoshiaki , Mukai Kenta , Isogai Akira 
Published: February 2023

AbstractThe adsorption isotherms, kinetics, and thermodynamics of fluoride ions (F−) on FeOOH powders in water were investigated to obtain fundamental information on FeOOH powders, which are used as F− adsorbents in drinking and industrial water, and industrial wastewater. FeOOH powders were prepared as precipitates by mixing aqueous FeCl3 and NaOH solutions (1:3 mol/mol) in the presence of 2,2,6,6,-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized cellulose nanofibrils (TOCNs), carboxymethylcellulose (CMC), or TEMPO-oxidized cellulose (TOC) fibers (without nanofibrillation), and subsequent drying and pulverizing. The FeOOH:TOCN, FeOOH:CMC, and FeOOH:TOC dry mass ratios were controlled at 87:13. The amount of F− adsorbed by the FeOOH/TOCN powder per FeOOH mass was higher than those adsorbed by FeOOH, FeOOH/CMC, or FeOOH/TOC. The F− adsorption isotherms on the FeOOH-containing powders showed higher correlation coefficients with the Langmuir model than with the Freundlich model. This indicates that F− adsorbed on FeOOH initially formed a monolayer, predominantly via physical adsorption. Pseudo-second-order kinetics fitted well to the time-dependent F− adsorption behaviors on the FeOOH-containing powders. Thermodynamic analysis of F− adsorption on the FeOOH-containing powders showed that the ΔG values were negative, which indicates that F− adsorption on the FeOOH-containing powders proceeded spontaneously in water. The negative ΔG value for FeOOH/TOCN was higher than those for FeOOH, FeOOH/CMC, and FeOOH/TOC at the same temperature. This shows that the FeOOH/TOCN powder can be used as an excellent and efficient F− adsorbent in water.
Graphical abstract
Dormancy and Physiological Age of Seed Tubers from a Diverse Set of Potato Cultivars Grown at Different Altitudes and in Different Seasons in Kenya
Authors: Kwambai Thomas K. , Griffin Denis , Nyongesa Moses , Byrne Stephen , Gorman Monica , Struik Paul C. 
Published: February 2023

AbstractThe study was conducted to determine the dormancy and physiological age characteristics of diverse potato genotypes as influenced by growing altitudes and seasons for future breeding strategies and optimal patterns of use. Dormancy and sprouting characteristics have an impact on tuber production, storability and seed quality for planting and ware for consumption and the market. This study presents the results of dormancy and physiological age measurements conducted on 47 potato genotypes grown at three altitudes with three replications at each location and in two contrasting growing seasons. The seed tubers were evaluated at low altitude under darkness on moist sand storage conditions to assess their dormancy release, number of sprouts, sprout weight, sprout length and percentage tuber weight loss. Results showed significant (p < 0.001) differences among genotypes, locations and seasons, and significant interactions between these factors for days to dormancy release, number of sprouts per tuber at dormancy release and at 45 days after dormancy release, length of longest sprout, weight loss percentage of unsprouted and sprouted tubers at dormancy release and at 45 days after dormancy release, respectively. There was a wide variation in time to dormancy release (54 to 136 days); most genotypes showed medium to long dormancy. Seed tubers grown at low altitude showed longer dormancy than those grown at higher altitudes, while genotypic differences in dormancy were very consistent across environments. Genotypes strongly differed in sprouting characteristics and weight loss. There were highly significant interactions between altitude and season for all variables assessed, except for the number of sprouts 45 days after dormancy release and the weight loss after sprouting. Generally, the genotypic effects were larger than those of altitude, season and the interaction effects for all variables evaluated. This paper will allow variety selection to optimize seed quality at planting and minimize storage losses while providing new targets for breeders.
Utilising an accelerated Delphi process to develop consensus on the requirement and components of a pre-procedural core robotic surgery curriculum
Authors: Burke Joshua Richard , Fleming Christina A. , King Martin , El-Sayed Charlotte , Bolton William S. , Munsch Chris , Harji Deena , Bach Simon P. , Collins Justin W. 
Published: February 2023

AbstractRobot-assisted surgery (RAS) continues to grow globally. Despite this, in the UK and Ireland, it is estimated that over 70% of surgical trainees across all specialities have no access to robot-assisted surgical training (RAST). This study aimed to provide educational stakeholders guidance on a pre-procedural core robotic surgery curriculum (PPCRC) from the perspective of the end user; the surgical trainee. The study was conducted in four Phases: P1: a steering group was formed to review current literature and summarise the evidence, P2: Pan-Specialty Trainee Panel Virtual Classroom Discussion, P3: Accelerated Delphi Process and P4: Formulation of Recommendations. Forty-three surgeons in training representing all surgical specialties and training levels contributed to the three round Delphi process. Additions to the second- and third-round surveys were formulated based on the answers and comments from previous rounds. Consensus opinion was defined as ≥ 80% agreement. There was 100% response from all three rounds. The resulting formulated guidance showed good internal consistency, with a Cronbach alpha of > 0.8. There was 97.7% agreement that a standardised PPCRC would be advantageous to training and that, independent of speciality, there should be a common approach (95.5% agreement). Consensus was reached in multiple areas: 1. Experience and Exposure, 2. Access and context, 3. Curriculum Components, 4 Target Groups and Delivery, 5. Objective Metrics, Benchmarking and Assessment. Using the Delphi methodology, we achieved multispecialty consensus among trainees to develop and reach content validation for the requirements and components of a PPCRC. This guidance will benefit from further validation following implementation.
The risk of mortality and severe illness in patients infected with the omicron variant relative to delta variant of SARS-CoV-2: a systematic review and meta-analysis
Authors: Kow Chia Siang , Ramachandram Dinesh Sangarran , Hasan Syed Shahzad 
Published: February 2023

AbstractWe summarized through systematic review and meta-analysis of observational studies the risk of mortality as well as severe illness of COVID-19 caused by omicron variant relative to delta variant of SARS-CoV-2. A total of twelve studies were included. Our results showed significantly reduced odds of mortality (pooled OR = 0.33; 95% CI: 0.16–0.67) and significantly reduced odds of severe illness (pooled OR = 0.24; 95% CI: 0.21–0.28) in patients infected with the omicron variant of SARS-CoV-2 relative to their counterparts infected with the delta variant. Findings of lower disease severity following infection with the omicron variant of SARS-CoV-2 than the delta variant are encouraging during the ongoing transition from the pandemic phase into the endemic phase of COVID-19.
An atypical death from Rapunzel syndrome: a case report
Authors: Piras Gianluca Nicolò , Tomassini Luca , Bottoni Edoardo , di Gioia Cira , Ciallella Costantino 
Published: February 2023

AbstractTrichotillomania is a psychiatric disorder characterized by recurring urges to pulling out hairs, eyelashes, or down in other parts of the body. Trichophagia, which is the urge to ingesting the pulled-out hairs, can cause Rapunzel syndrome, an unusual disorder where gastric trichobezoars can be found in the small intestine. Trichobezoars, amorphous masses composed of undigested food formed by hairs, can obstruct the gastrointestinal tract up to simulating symptoms typical of bowel obstruction. Rapunzel syndrome, named after Grimm’s tale, may cause death, especially in the pediatric population, being it seldom over the age of 6; moreover, developing countries and environmental and familiar issues are listed as uncertain risk factors. The present case report deals with the death of a 4-year-old female occurred after lunch and following a series of vomit events; while no traumatic or pathological findings were revealed at the external examination, the autopsy revealed three large trichobezoars localized in the stomach and the small intestine. Despite death was due to gastrointestinal obstruction for multiple trichobezoars and collateral bronchoaspiration of dietary material, histological findings were totally non-specific, meaning that it is sometimes difficult to conclude that death is related to the primary pathological condition.
Gallic acid diminishes pro-inflammatory interferon-γ- and interleukin-17-producing sub-populations in vitro in patients with psoriasis
Authors: Tsiogkas Sotirios G. , Apostolopoulou Konstantina , Mavropoulos Athanasios , Grammatikopoulou Maria G. , Dardiotis Efthimios , Zafiriou Efterpi , Bogdanos Dimitrios P. 
Published: February 2023

Abstract
Psoriasis is an inflammation of the skin mediated via the IL-23/Thl17/IL-17 pathway. We have previously demonstrated that the anthocyanin delphinidin diminishes in vitro the IL-17 and IFN-γ production of peripheral monocytes isolated by psoriasis patients (PBMCs). The degradation product of delphinidin is gallic acid (GA). This phenolic acid compound found in fruits, red wine, or green tea exerts pleiotropic antioxidant, anticarcinogenic, antimicrobial, and anti-inflammatory properties. Previous research has demonstrated the inhibitory effect of GA on pro-inflammatory transcription factors, such as STAT3, RORγt, and NF-κB, or cytokines as IL-1β and TNF, which contribute to psoriasis development. We investigated the effect of GA in vitro on PBMCs, which were stimulated ex vivo, from 40 individuals (28 diagnosed with psoriasis vulgaris and 12 healthy controls (HCs)). In our experiments, PBMCs were cultured untreated or were activated in the presence of phorbol 12-myristate 13-acetate/ionomycin with or without GA. We utilized multicolor flow cytometry to assess the production of inteleukin-17 (IL-17) and interferon-γ (IFN-γ) in T and NK cells. GA did not alter the fractions of IL-17- or IFN-γ-producing T and IFN-γ-producing NK cells in HCs. However, in psoriasis patients, the effect of GA on that cell population was significant. Specifically, GA decreased the frequency of IL-17-producing cells within the CD3+ (T) and CD3+CD4+ (Th) compartment; the frequency of IFN-γ-producing cells within the CD3+, CD3+CD4+, and CD3+CD4− (Tc) compartment, and the frequency of IFN-γ-producing cells within the CD3−CD56+ (NK) compartment. Whether GA’s effect also appears in vivo needs to be investigated in future.
C4 Equivalent Decarboxylation Competence in Tropical Orchids
Authors: Mukundan Nidhi S. , Banerjee Sunaina , Kumar Shruti , Satyamoorthy Kapaettu , Babu Vidhu Sankar 
Published: February 2023

AbstractTropical xero-epiphytic orchids undergo a photosynthetic mechanism called ‘Crassulacean Acid Metabolism’, a modification of Calvin–Benson cycle. This anabolic process aids in the long-term retention of organically fixed CO2, imprinting them as active sequestrators and fixers of gaseous CO2. The malate decarboxylation competence of enzymes—phosphoenolpyruvate carboxykinase (PEPCK), Nicotinamide Adenine Dinucleotide malic enzyme (NAD-ME) and Nicotinamide Adenine Dinucleotide Phosphate malic enzyme (NADP-ME) in xero-epiphytic orchids that concentrate CO2 by employing RuBisCO to embark on a carboxylation route is defined in this paper. Physiological parameters like photosynthetic rates, and quantum yield, accompanied by histomorphometry were analysed. Our study indicated PEPCK as the dominant decarboxylating enzyme in tropical orchids. The efficiency of PEPCK was reinforced by two additional malic enzymes, which are dependent on cofactors, namely Nicotinamide Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Phosphate. These results indicated the need to appraise the potential of tropical orchids as strategic plant contenders for CO2 triggered greenhouse effect mitigator.