bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of metric accuracy on data acquisition using point cloud: an application to the José de Alencar Theater
Authors: FIDELES Bruna Tayna Macedo , MESQUITA Esequiel Fernandes Teixeira , MOREIRA Eugênio , VIEIRA Mylene Melo 
Published: April 2023

Abstract
The data acquisition process is an important step in capturing information, especially when it comes to historical heritage documentation, these buildings often have complex structures and little collection, which makes the geometric survey process by the traditional way even more difficult. Currently studies have been conducted using 3D terrestrial laser scanner (TLS) as a capture of geometric information in order to generate point clouds and serve as a basis for analysis, including using BIM and facilitate this documentation process. The paper was developed from a theoretical basis on the subject and application, performing a metric evaluation comparing existing point cloud and 2D surveys, in order to generate a database and propose a method to improve dimensional inspections through point clouds in historic buildings, where it was possible to note some differences in shape and measurement between the two surveys. The study was validated on the metal façade of the José de Alencar Theater.
Inflammation and digestive reflux in the pancreatic stump after pancreaticoduodenectomy subtitle: Mechanisms of pancreatic fistula
Authors: Wang Tiegong , Tian Liang , Zhang Xiaoling , Xu Yanfeng , Che Yanxu , Zhang Lei , Zhao Xiulei , Kong Deshuai , Luo Yi 
Published: April 2023

Abstract
Background and Objectives: Postoperative pancreatic fistula (POPF) contributes to significant morbidity and mortality after pancreaticoduodenectomy (PD). However, the underlying mechanisms of POPF remain unclear. This study is to explore the pathology in the pancreatic stump and elucidates the mechanisms of POPF following PD.
Methods: Pathological analysis and 16S rRNA gene sequencing were performed on the specimens obtained from the two patients who accepted complete pancreatectomy for grade C POPF after PD. In addition, a retrospective radiological analysis was conducted on a cohort of 125 consecutive patients who underwent PD to evaluate the inflammatory response in the pancreatic stump.
Results: The presence of gradient inflammation and acinar-duct metaplasia (ADM) in the pancreatic stumps is ubiquitous. The incidence of apoptosis is markedly reduced in the pancreatic stump. Moreover, a significant accumulation of neutrophil-dominated inflammatory cells is detected in the ductal system. Notably, the ADM-formed duct is the site where the neutrophils transmigrate through the ductal wall. Additionally, the microbial evidence indicates that gut microbes migrate from the digestive tract. Radiological analysis proves that a gradient of pancreatitis exists in all cases after PD and reaches peak on the fourth postoperative day.
Conclusions: Inflammation and digestive reflux exist in the pancreatic stump after PD. The underlying mechanisms of POPF are the high biochemical activity of the pancreas, mechanical injury, and digestive reflux.
The comprehensive bioinformatic analysis of the hsa-miR-3613-5p in kidney renal clear cell carcinoma
Authors: Ahmadi Mohsen , Ghaderian Sayyed Mohammad Hossein , Morshedzadeh Firouzeh , Najari-Hanjani Parisa , Ghaffarnia Roya , Kenzerkie Maryam Eftekhari , Mousavi Pegah , Ghafouri-Fard Soudeh 
Published: April 2023

Abstract
microRNA-3613 (hsa-miR-3613-5p), a biomarker with a dual role, oncogenic or tumor suppressor, is associated with different types of cancers. This study aimed to assess the correlation between the hsa-miR-3613-5p gene expression and Kidney renal clear cell carcinoma (KIRC). Using several bioinformatics tools, we examined the expression level and clinicopathological value of hsa-miR-3613-5p in patients with KIRC compared to normal tissues. Other metrics include survival analysis, diagnostic merit of hsa-miR-3613-5p, downstream target prediction, potential upstream lncRNAs, network construction, and functional enrichment analysis hsa-miR-3613-5p, were performed. We observed that overexpression of hsa-miR-3613-5p in KIRC tissues had valuable diagnostic merit and significantly was correlated with the poor overall survival of KIRC patients. We also realized a correlation between abnormal expression hsa-miR-3613-5p and several clinical parameters such as pathological stage, race, age, and histological grades of patients with KIRC. Moreover, we identified the most potential regulatory of hsa-miR-3613-5p in KIRC with 17 different axes, including four pseudogenes, two lncRNAs, and three mRNAs. Besides, we discovered six variants in mature miRNA of hsa-miR-3613-5p. Finally, pathway enrichment analysis uncovered that top-ranked pathways for hsa-miR-3613-5p are cell cycle, cell adhesion molecules (CAMs), and hepatocellular carcinoma pathways. The present report demonstrated that the higher expression of hsa-miR-3613-5p is associated with the progression of KIRC, therefore. It may be considered a valuable indicator for the early detection, risk stratification, and targeted treatment of patients with KIRC.
Nutrition Sensitivity of Smallholder Agricultural Production in Northwest Ethiopia
Authors: Agitew Genanew , Berhanie Zewdu , Gebremedhin Samson 
Published: April 2023

Abstract
Background
Nutrition-sensitive agriculture is a production approach to the ensure production of a variety of affordable, nutritious, culturally appropriate, and safe foods in adequate quantity and quality to meet dietary requirements. The objective of the study was to assess the nutrition sensitivity of smallholder agriculture.
Methods
The study was conducted in four districts of northwest Ethiopia. Data were generated from 748 randomly sampled households using a structured questionnaire-based survey. The analysis was performed using the production diversity score and Simpson’s Diversity Index of food groups produced. A multiple linear regression model was employed to identify factors affecting the production of diversified food groups.
Results
The study revealed that smallholder households on average produce 6.08 food groups out of 12. The production diversity index of smallholder food production is also found to be 88.6%. Multiple linear regression analysis results, on the other hand, shows that the sex of the household head, year of schooling, farming experience, number of oxen, contact with agricultural extension worker, irrigation use, and availability of animal feed are statistical significant factors positively affecting on-farm production diversity of smallholders. Conversely, the age of the household head negatively affected production diversity.
Concluding Remarks:
The study concludes that smallholder agricultural production in northwest Ethiopia is nutrition-sensitive and can supply minimum dietary diversity to households. Promoting small-scale irrigation schemes and strengthening nutrition-sensitive agricultural extension services could contribute to food and nutrition security.
Spectral theorems for Wigner transform associated with the Laguerre-Bessel localization operators
Authors: Chana Ahmed , Akhlidj Abdellatif 
Published: April 2023

Abstract
The main crux of this work is to study the Wigner transform associated with the Laguerre-Bessel operator and to give some results related to this transform. Next motivated by Wong's point of view we define a class of pseudo-differential operator Lu,v (σ) called localization operator wich depend on a symbol σ and two functions u and v, we give a criteria in terms of the symbol σ for its boundedness and compactness, we also show that these operators belongs to the Schatten-Von Neumann class S p for all p ∈ [1; + ∞] and we give a trace formula.
MSC2020-Mathematics Subject Classification: 42B10, 47G30, 47B10.
Pengembangan Model Arsitektural Virtual Expo sebagai Media Alternatif Pembelajaran Kewirausahaan
Authors: Cininta Mutiara , Wibisono Yohanes Priadi 
Published: April 2023

Title: Development of Virtual Expo Architectural Model as an Alternative Media for Entrepreneurship Learning

Participating in an exhibition plays a vital role in the learning process of entrepreneurship. Exhibitions can be a means to practice selling and introducing products or services, exploring competitor activities, dialogue and demonstrations with potential buyers, and establishing networks with distributors and investors. During the pandemic, there were limited exhibitions due to physical distancing. Although technological developments have made virtual expos possible, MSME players often need help to keep up with the ever-growing digital transformation. Therefore, entrepreneurship education should integrate digital literacy competencies to increase future generations' resilience. This research uses the Research and Development (R&D) method with the ADDIE (Analyze, Design, Development, Implementation, Evaluate) development model. This study proposes a virtual expo model developed using SketchUp, Enscape, and Blender. Virtual Expo as a learning medium has feature criteria that allow participants to practice basic skills in entrepreneurship, including the ability to do promotions (pitching), formulate branding and marketing strategies, make prototypes, and present business plans. The metaverse-based prototype is more recommended for entrepreneurial learning media because it can facilitate real-time interactions such as presentations with visible cameras and gestures, booth designs displayed with three-dimensional models, and more interactive product presentations.
Assessment of the sensitivity of water resources in the intertropical zone: a bibliographical study with perspectives
Authors: Mba Franck Fabrice , Temgoua Emile , Djousse Kanouo Boris Merlain , Tontsa Lauric , Wowinwo Ramces Takoubo , Kamhoua Cerge Natheu 
Published: April 2023

Abstract
Study of the vulnerability of water resources contributing to consumer health in the inter-tropical zone. The aim of this paper is to present the state of the art on the protection of water resources in the inter-tropical zone in order to identify gabs in knowledge that improve drinking water supply. To achieve this, a documentary search online was carried out to assess the progression of work over time. What emerges from this literature review is that the method for assessing intrinsic and specific vulnerability in bedrock areas is practically non-existent. A discrepancy exists and reflects the difference in a coincidence of the level of vulnerability when several methods of determining vulnerability are used in the same study site. The issue of validation is still problematic, as it lies in the fact that a property that is not precisely defined cannot be unambiguously deduced from the measured quantity. The characterisation of specific pollutants and their propagation in the saturated or groundwater zone are not taken into account. All the different components of the water cycle are not always taken into account during a groundwater vulnerability study, yet each water resource is part of a closely related component of the water cycle.
Nonsynonymous Synonymous Variants Demand for a Paradigm Shift in
Genetics
Authors: Vihinen Mauno 
Published: April 2023

Abstract:
Synonymous (also known as silent) variations are by definition not considered to change
the coded protein. Still many variations in this category affect either protein abundance or properties.
As this situation is confusing, we have recently introduced systematics for synonymous variations and
those that may on the surface look like synonymous, but these may affect the coded protein in various
ways. A new category, unsense variation, was introduced to describe variants that do not introduce a
stop codon into the variation site, but which lead to different types of changes in the coded protein.
Many of these variations lead to mRNA degradation and missing protein. Here, consequences of the
systematics are discussed from the perspectives of variation annotation and interpretation, evolutionary
calculations, nonsynonymous-to-synonymous substitution rates, phylogenetics and other evolutionary
inferences that are based on the principle of (nearly) neutral synonymous variations. It may be
necessary to reassess published results. Further, databases for synonymous variations and prediction
methods for such variations should consider unsense variations. Thus, there is a need to evaluate and
reflect principles of numerous aspects in genetics, ranging from variation naming and classification to
evolutionary calculations.
Increased Prevalence of Gastroesophageal Reflux Disease Among Patients
With Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Authors: Thongpiya Jerapas , Charoenngam Nipith , Ponvilawan Ben , Yingchoncharoen Pitchaporn , Jaroenlapnopparat Aunchalee , Ungprasert Patompong 
Published: April 2023

Objective:
This study was conducted to determine the association between gastroesopha-geal reflux disease (GERD) and rheumatoid arthritis (RA) by pooling the evidence from all availa-ble studies.

Methods:
Potentially eligible studies were identified from MEDLINE and EMBASE database from inception to April 2021 employing a search strategy that consisted of terms for “Rheumatoid Arthri-tis” and “Gastroesophageal Reflux Disease”. Eligible studies for the meta-analysis were recruited with conditions of being cohort studies that included rheumatoid arthritis and without rheumatoid arthritis individuals. Together with this, prevalence of GERD in both groups and the odds ratio (OR) comparing the prevalence of GERD between the two cohorts have been reported. The re-trieved point estimates with standard errors from each study were pooled into the final result by the random-effect model and generic inverse variance method as described by DerSimonian and Laird.

Results:
A total of 3,646 articles were identified. After two rounds of independent review by two investigators, five cohort studies were included in the meta-analysis as they met the eligibility crite-ria. The pooled analysis demonstrated a significant association between RA and GERD with the pooled odds ratio of 1.98 (95% CI, 1.49 - 2.65). High statistical heterogeneity with I2 of 83% was observed. The funnel plot was symmetric and publication bias was not observed.

Conclusion:
This systematic review and meta-analysis found a significant association between GERD and RA.
Recurrent Plunging Ranula – A Rare Case Report
Authors: Bharti Jyotsna Naresh , Nigam Jitendra Singh 
Published: April 2023

Background:
Plunging ranula is a variant of ranula, which present as a painless subcutaneous anterolateral neck mass and is located beyond the mylohyoid
muscle. Plunging ranula is a diagnostic challenge and can present with intraoral component.

Case Report:
An elderly male presented with painless neck mass in the cervical region for three months. The mass was excised, and the patient is doing well on
follow-up. We report a case of recurrent plunging ranula without any intraoral component.

Conclusion:
Whenever the intraoral component is missing in ranula, chances of misdiagnosis and mismanagement are high. Awareness of this entity and high
index of suspicion is needed for accurate diagnosis and effective management.
Screening of Inhibitors against Idiopathic Pulmonary Fibrosis: Few-shot
Machine Learning and Molecule Docking based Drug Repurposing
Authors: Chang Jun , Zou Shaoqing , Xu Subo , Xiao Yiwen , Zhu Du 
Published: April 2023

Introduction:
Idiopathic pulmonary fibrosis is a chronic progressive disorder and is
diagnosed as post-COVID fibrosis. Idiopathic pulmonary fibrosis has no effective treatment because
of the low therapeutic effects and side effects of currently available drugs.

Aim:
The aim is to screen new inhibitors against idiopathic pulmonary fibrosis from traditional
Chinese medicines.

Methods:
Few-shot-based machine learning and molecule docking were used to predict the potential
activities of candidates and calculate the ligand-receptor interactions. In vitro A549 cell model
was taken to verify the effects of the selected leads on idiopathic pulmonary fibrosis.

Results:
A logistic regression classifier model with an accuracy of 0.82 was built and, combined
with molecule docking, used to predict the activities of candidates. 6 leads were finally screened
out and 5 of them were in vitro experimentally verified as effective inhibitors against idiopathic
pulmonary fibrosis.

Conclusion:
Herbacetin, morusin, swertiamarin, vicenin-2, and vitexin were active inhibitors
against idiopathic pulmonary fibrosis. Swertiamarin exhibited the highest anti-idiopathic pulmonary
fibrosis effect and should be further in vivo investigated for its activity.
A Systematic Review on Pesticide-loaded Nanocapsules: A Sustainable
Route for Pesticide Management to Enhance Crop Productivity
Authors: Kumar Sumit , Bhuvaneshwari R , Jain Sejal , Nirwan Shweta , Fatima Zainab , Kumar Dharmender , Chhikara Bhupendra S. , Rathi Brijesh , Poonam  
Published: April 2023

Abstract:
Synthetic pesticides, crucial compounds for agricultural production, degrade quickly and
damage the environment, hence solutions for their decreased usage or formulations with prolonged
efficacy at low dosages are needed. Nanotechnology for nanosized formulations may reduce pesticide
adverse effects. Nano-encapsulated pesticides made from nanocapsules, nanoemulsions, micelles,
and nanogels outperform traditional pesticides with minimum environmental impact. Nanopesticides
allowed target-based administration to decrease leaching and drainage into water bodies,
and lower pesticide active component dosages. Nanocapsules with a core-shell configuration
and a pesticide in the core are the most advantageous nanomaterials. Nanocapsules shield the active
component. Stimuli-responsive nanocapsules may limit pesticide release by responding to pH, temperature,
light, enzyme, or redox reactions. Toxicity prevents their use. This review discusses the
latest developments in nanocapsule fabrication methods, their relevance, contemporary synthetic
approaches to developing pesticide-loaded nanocapsules, and the features of these nanocomposites,
with an emphasis on sustainable agricultural applications.
Recent Progresses on Pathophysiology, Diagnosis, Therapeutic Modalities,
and Management of Non-alcoholic Fatty Liver Disorder
Authors: Barazesh Mahdi , Jalili Sajad , Akhzari Morteza , Faraji Fouzieyeh , Khorramdin Ebrahim 
Published: April 2023

Abstract:
Non-alcoholic fatty liver disease (NAFLD) is currently the utmost common chronic liver
disorder that happens through all age groups and is identified to occur in 14%-30% of the general
population, demonstrating a critical and grossing clinical issue because of the growing incidence of
obesity and overweight. From the histological aspect, it looks like alcoholic liver damage, but it happens in patients who avoid remarkable alcohol usage. NAFLD comprises a broad spectrum, ranging
from benign hepatocellular steatosis to inflammatory nonalcoholic steatohepatitis (NASH), different
levels of fibrosis, and cirrhosis. Patients with NASH are more susceptible to more rapid progression to
cirrhosis and hepatocellular carcinoma. There is no single factor that drives proceeding from simple
steatosis to NASH. However, a combination of multi parameters such as genetic background, gut microflora, intake of high fat/ fructose dietary contents or methionine/choline-deficient diet, and consequently accumulated hepatocellular lipids mainly including triglycerides and also other bio-analytes,
such as free fatty acids, cholesterol, and phospholipids display a crucial role in disease promotion.
NAFLD is related to overweight and insulin resistance (IR) and is regarded as the hepatic presentation
of the metabolic syndrome, an amalgamation of medical statuses such as hyperlipidemia, hypertension, type 2 diabetes, and visceral obesity. Despite the increasing prevalence of this disease, which
imposes a remarkable clinical burden, most affected patients remain undiagnosed in a timely manner,
largely related to the asymptomatic entity of NAFLD patients and the unavailability of accurate and
efficient noninvasive diagnostic tests. However, liver biopsy is considered a gold standard for NAFLD
diagnosis, but due to being expensive and invasiveness is inappropriate for periodic disease screening.
Some noninvasive monitoring approaches have been established recently for NAFLD assessment. In
addition to the problem of correct disease course prediction, no effective therapeutic modalities are
approved for disease treatment. Imaging techniques can commonly validate the screening and discrimination of NAFLD; nevertheless, staging the disease needs a liver biopsy. The present therapeutic approaches depend on weight loss, sports activities, and dietary modifications, although different insulin-sensitizing drugs, antioxidants, and therapeutic agents seem hopeful. This review aims to focus on
the current knowledge concerning epidemiology, pathogenesis, and different biochemical experiments
and imaging modalities applied to diagnose the different grades of NAFLD and its management, as
well as new data about pharmacological therapies for this disorder.
Diterpenoid Tanshinone Attenuates the Metastasis of Non-small-cell Lung Cancer
(NSCLC) Cells by Inhibiting the Cavin-1-mediated ERK/Smad2 Signaling Pathway
Authors: Wang Lu , Jiang Gangdan , Li Xiaojuan 
Published: April 2023

Background:
Non-small cell lung cancer (NSCLC) is a common malignant cancer with high incidence and
mortality. In recent decade, despite the progress in the treatment and prevention of NSCLC, its prognosis still remains
poor. It is urgently needed to identify new potential mechanism and efficacious drugs for NSCLC patients.

Objective:
The objective of this study is to explore the potential therapeutic role of diterpenoid tanshinone (DT) against
non-small cell lung cancer (NSCLC) in vitro and elucidate the molecular mechanism involved in tumor metastasis.

Methods:
Human NSCLC lines (A549 and NCI-H1299) were transfected with pcDNA3.1-Cavin-1 plasmids and corresponding
controls. We tested the effects of DT on migration and invasion of lung cancer cells using transwell filters
coated with fibronectin and Matrigel. Next, Quantitative Real-Time PCR and western blot were used to determine the
transcriptional and protein levels of epithelial-mesenchymal transition (EMT) markers, transcription factors (Snail,
Slug), and matrix metalloproteinases.

Results:
As expected, Cavin-1 related to the enhanced ability of cell migration and invasion. DT not only inhibited the
migratory and invasive capacity of Cavin-1-transfected NSCLC cells but also significantly increased the expression of
ZEB1 and E-cadherin and decreased the level of N-cadherin, Vimentin, Snail, and Slug. Moreover, DT treatment obviously
alleviated Cavin-1 overexpression-induced high levels of MMP2, MMP7, and MMP9 at both the protein and
transcriptional levels. Furthermore, overexpressed Cavin-1 upregulated ERK and Smad2 signaling pathways in
NSCLC cells, which were also strongly weakened by DT administration.

Conclusion:
Our results suggested that DT effectively attenuates Cavin-1-mediated NSCLC metastasis via the
ERK/Smad2 signaling pathway.