bluuebunny/crossref_metadata_2025_split huggingface dataset:
A four-port wideband filtering monopole MIMO array for sub-6 GHz 5G communications
Authors: Ayyappan Jasmine Vijithra , Mohammed Gulam Nabi Alsath , Subbaraj Sangeetha 
Published: April 2023

AbstractThis communication presents the significance of a four-port 2×2 multiple input multiple output antenna operating in mid-band frequency for 5G handheld device application. A microstrip-fed reference truncated decagonal monopole antenna operating at 3.9 GHz and a modified split-ring resonator (SRR)-based low-pass filter that excites at a cut-off frequency of 6.5 GHz are designed. On introducing a stub line in the SRR structure, the proposed filter shows a good out-of-band rejection beyond 6.5 GHz. By integrating the filter into the reference monopole, a wideband filtering monopole with improved stopband performance is obtained. A four-port MIMO array is constructed by orthogonally positioning the antenna with a center-to-center separation of 0.25λ0. To improve isolation, a pair of inverted L-stubs of varying lengths is introduced. The closed loop formed by the interconnection of stubs enhances isolation within the frequency range of 3–3.5 GHz. The fabricated prototype fosters an impedance bandwidth of 66.67%, isolation >18.5 dB, an average suppression of 15 dB, an average peak gain >3.7 dB, envelope correlation coefficient < 0.015, Actual Diversity Gain (ADG) > 9.9 dB, Effective Diversity Gain (EDG) > 8.8 dB, and efficiency >88%. The proposed design is suitable for 5G sub-6 GHz applications such as n48, n77, n78, n79 bands, WiMAX, and LTE bands 42, 43, 46, 47, 48.
Adverse Health Outcomes Following Hurricane Harvey: A Comparison of Remotely‐Sensed and Self‐Reported Flood Exposure Estimates
Authors: Ramesh Balaji , Callender Rashida , Zaitchik Benjamin F. , Jagger Meredith , Swarup Samarth , Gohlke Julia M. 
Published: April 2023

AbstractRemotely sensed inundation may help to rapidly identify areas in need of aid during and following floods. Here we evaluate the utility of daily remotely sensed flood inundation measures and estimate their congruence with self‐reported home flooding and health outcomes collected via the Texas Flood Registry (TFR) following Hurricane Harvey. Daily flood inundation for 14 days following the landfall of Hurricane Harvey was acquired from FloodScan. Flood exposure, including number of days flooded and flood depth was assigned to geocoded home addresses of TFR respondents (N = 18,920 from 47 counties). Discordance between remotely‐sensed flooding and self‐reported home flooding was measured. Modified Poisson regression models were implemented to estimate risk ratios (RRs) for adverse health outcomes following flood exposure, controlling for potential individual level confounders. Respondents whose home was in a flooded area based on remotely‐sensed data were more likely to report injury (RR = 1.5, 95% CI: 1.27–1.77), concentration problems (1.36, 95% CI: 1.25–1.49), skin rash (1.31, 95% CI: 1.15–1.48), illness (1.29, 95% CI: 1.17–1.43), headaches (1.09, 95% CI: 1.03–1.16), and runny nose (1.07, 95% CI: 1.03–1.11) compared to respondents whose home was not flooded. Effect sizes were larger when exposure was estimated using respondent‐reported home flooding. Near‐real time remote sensing‐based flood products may help to prioritize areas in need of assistance when on the ground measures are not accessible.
Unprecedented Winter Rainfall Initiates Large Snow Avalanche and Mass Movement Cycle in New Zealand's Southern Alps/Kā Tiritiri o te Moana
Authors: Miller Aubrey D. , Redpath Todd A. N. , Sirguey Pascal , Cox Simon C. , Bartelt Perry , Bogie Don , Conway Jono P. , Cullen Nicolas J. , Bühler Yves 
Published: April 2023

AbstractAn exceptional July 2022 winter storm brought 550 mm of precipitation to the Southern Alps of New Zealand. A series of alpine mass movements occurred during the storm, including a widespread snow avalanche cycle, debris flows, and erosion from rain runoff. We detail the sequence of events in the Kitchener avalanche path. Here, two large snow avalanches were followed by a debris flow. Substantial erosion of deposition and the underlying alluvial fan were induced by runoff from over 300 mm of rain falling after the first avalanche. The Kitchener path saw the largest avalanche since 1986, testing the utility of a diversion berm constructed for a 1:100‐year event. Results from a unmanned aerial vehicle lidar survey and numerical modeling characterize the rain‐on‐snow hazard sequence. In particular, the rain‐on‐snow event occurred on a deep mid‐winter snowpack, offering insights into future hazards posed by increasingly frequent extreme alpine precipitation.
Water Table and Permeability Estimation From Multi‐Channel Seismoelectric Spectral Ratios
Authors: Hu Kaiyan , Ren Hengxin , Huang Qinghua , Zeng Ling , Butler Karl E. , Jougnot Damien , Linde Niklas , Holliger Klaus 
Published: April 2023

AbstractRecent developments in predicting and interpreting seismoelectric (SE) signals suggest a great potential for studying near‐surface hydrogeological properties, particularly in the vadose zone. Previous studies have revealed that the SE spectral ratios obtained from earthquake‐triggered SE data contain valuable hydrogeological information concerning porous media (e.g., permeability, porosity, fluid viscosity, and salinity). This study introduces Multi‐Channel SeismoElectric Spectral Ratios (MC‐SESRs) by considering an active seismic source acting on the ground surface. The frequency‐ and saturation‐dependent excess charge density is adopted to calculate the cross‐coupling coefficients. Applying a supervised learning task based on a flat neural network, the so‐called “broad learning (BL)” model, to map and extract the features of MC‐SESRs data, we seek to determine the permeability and the water table depth. Our results indicate that (a) MC‐SESRs are sensitive to the water table depth and permeability; (b) using more traces of SESRs data for inversion can increase accuracy; and (c) the changing water table can be rapidly determined by the MC‐SESRs by resorting to the BL inverse model, and it can attain an excellent accuracy while disturbed by data noise and misspecified model parameters (e.g., porosity and permeability) with errors of up to 20%. The proposed MC‐SESRs inversion has potential applications for non‐invasive monitoring in shallow porous media (e.g., frost thawing and geothermal upwelling).
Late Oligocene Formation of the Pearl River Triggered by the Opening of the South China Sea
Authors: Zhang Zengjie , Daly J. Stephen , Tian Yuntao , Lei Chao , Sun Xilin , Badenszki Eszter , Qin Yonghui , Hu Jie 
Published: April 2023

AbstractThe Pearl River is one of the largest rivers entering the South China Sea, yet its initiation time remains debated, a topic we address using Pb isotopes in detrital K‐feldspar. Based on these Pb data, Eocene and Early Oligocene sandstones from the northern South China Sea are interpreted to have been supplied with sediment by proximal rivers draining the Cathaysia Block. In contrast, the Late Oligocene and Miocene sandstones are mainly derived from the western Pearl tributaries (e.g., Hongshui River), suggesting that the Pearl River had formed by the Late Oligocene. Detrital zircon data from the Beibuwan Basin previously suggested that the western tributaries flowed into this basin before being captured by the paleo‐Pearl River. These lines of evidence suggest that progressive headward erosion of the eastern Pearl River and late Oligocene integration of this large fluvial system can be linked to contemporaneous sea‐floor spreading of the South China Sea.
A Linear Velocity Gradient in the Subsolar Magnetosheath
Authors: Silveira M. V. D. , Sibeck D. G. 
Published: April 2023

AbstractTracking the location and motion of the bow shock and magnetopause can reveal many aspects concerning the nature of the solar wind‐magnetosphere interaction. In the absence of missions that image the magnetopause, we propose to detect and track the magnetopause and bow shock motion using multipoint in situ observations of the magnetosheath. Making theoretical assumptions corroborated by numerical simulations, Sibeck et al. (2022, https://doi.org/10.1029/2022JA030704) proposed a method to predict the subsolar magnetopause and the bow shock from the linear variation in magnetosheath plasma velocity expected from global magnetohydrodynamic simulations along the Sun‐Earth line. This paper presents a case study that employs the velocity gradient method using multi‐point THEMIS plasma observations from 21 to 22 June 2007. Using the five THEMIS spacecraft we demonstrate that the radial gradient in plasma velocity remains nearly linear across the subsolar magnetosheath, except when the magnetosheath lies behind the quasi‐parallel bow shock and conditions are very turbulent. The bow shock and magnetopause move outward in response to a gradual decrease in solar wind dynamic pressure. We show that results from the velocity gradient method agree well with predictions of global magnetohydrodynamic and empirical models for this time interval. The velocity gradient method can therefore be used to remotely determine the location of the magnetopause and bow shock, solely based on two‐spacecraft measurements at the subsolar magnetosheath when not downstream of the quasi‐parallel shock.
Sugar-sweetened beverages, low/no-calorie beverages, fruit juice and non-alcoholic fatty liver disease defined by fatty liver index: the SWEET project
Authors: Naomi Novita D. , Ngo Joy , Brouwer-Brolsma Elske M. , Buso Marion E. C. , Soedamah-Muthu Sabita S. , Pérez-Rodrigo Carmen , Harrold Joanne A. , Halford Jason C. G. , Raben Anne , Geleijnse Johanna M. , Serra-Majem Lluis , Feskens Edith J. M. 
Published: April 2023

Abstract

Background
Sweetened beverage intake may play a role in non-alcoholic fatty liver disease (NAFLD) development, but scientific evidence on their role is limited. This study examined associations between sugar-sweetened beverages (SSB), low/no-calorie beverages (LNCB) and fruit juice (FJ) intakes and NAFLD in four European studies.

Methods
Data for 42,024 participants of Lifelines Cohort, NQPlus, PREDIMED-Plus and Alpha Omega Cohort were cross-sectionally analysed. NAFLD was assessed using Fatty Liver Index (FLI) (≥60). Restricted cubic spline analyses were used to visualize dose–response associations in Lifelines Cohort. Cox proportional hazard regression analyses with robust variance were performed for associations in individual cohorts; data were pooled using random effects meta-analysis. Models were adjusted for demographic, lifestyle, and other dietary factors.

Results
Each additional serving of SSB per day was associated with a 7% higher FLI-defined NAFLD prevalence (95%CI 1.03–1.11). For LNCB, restricted cubic spline analysis showed a nonlinear association with FLI-defined NAFLD, with the association getting stronger when consuming ≤1 serving/day and levelling off at higher intake levels. Pooled Cox analysis showed that intake of >2 LNCB servings/week was positively associated with FLI-defined NAFLD (PR 1.38, 95% CI 1.15–1.61; reference: non-consumers). An inverse association was observed for FJ intake of ≤2 servings/week (PR 0.92, 95% CI: 0.88–0.97; reference: non-consumers), but not at higher intake levels. Theoretical replacement of SSB with FJ showed no significant association with FLI-defined NAFLD prevalence (PR 0.97, 95% CI 0.95–1.00), whereas an adverse association was observed when SSB was replaced with LNCB (PR 1.12, 95% CI 1.03–1.21).

Conclusions
Pooling results of this study showed that SSB and LNCB were positively associated with FLI-defined NAFLD prevalence. Theoretical replacement of SSB with LNCB was associated with higher FLI-defined NAFLD prevalence. An inverse association was observed between moderate intake of FJ and FLI-defined NAFLD. Our results should be interpreted with caution as reverse causality cannot be ruled out.
Effects of cannabidiol on anandamide levels in individuals with cannabis use disorder: findings from a randomised clinical trial for the treatment of cannabis use disorder
Authors: Hua Daniel Ying-Heng , Hindocha Chandni , Baio Gianluca , Lees Rachel , Shaban Natacha , Morgan Celia J. , Mofeez Ali , Curran H. Valerie , Freeman Tom P. 
Published: April 2023

AbstractCannabidiol (CBD) has shown promise in treating psychiatric disorders, including cannabis use disorder – a major public health burden with no approved pharmacotherapies. However, the mechanisms through which CBD acts are poorly understood. One potential mechanism of CBD is increasing levels of anandamide, which has been implicated in psychiatric disorders including depression and cannabis use disorder. However, there is a lack of placebo-controlled human trials investigating this in psychiatric disorders. We therefore assessed whether CBD affects plasma anandamide levels compared to placebo, within a randomised clinical trial of CBD for the treatment of cannabis use disorder. Individuals meeting criteria for cannabis use disorder and attempting cannabis cessation were randomised to 28-day administration with placebo (n = 23), 400 mg CBD/day (n = 24) or 800 mg CBD/day (n = 23). We estimated the effects of each CBD dose compared to placebo on anandamide levels from baseline to day 28. Analyses were conducted both unadjusted and adjusted for cannabis use during the trial to account for effects of cannabis on the endocannabinoid system. We also investigated whether changes in plasma anandamide levels were associated with clinical outcomes relevant for cannabis use disorder (cannabis use, withdrawal, anxiety, depression). There was an effect of 800 mg CBD compared to placebo on anandamide levels from baseline to day 28 after adjusting for cannabis use. Pairwise comparisons indicated that anandamide levels unexpectedly reduced from baseline to day 28 in the placebo group (−0.048, 95% CI [−0.089, −0.007]), but did not change in the 800 mg CBD group (0.005, 95% CI [−0.036, 0.047]). There was no evidence for an effect of 400 mg CBD compared to placebo. Changes in anandamide levels were not associated with clinical outcomes. In conclusion, this study found preliminary evidence that 28-day treatment with CBD modulates anandamide levels in individuals with cannabis use disorder at doses of 800 mg/day but not 400 mg/day compared to placebo.
Bone serves as a transfer station for secondary dissemination of breast cancer
Authors: Huang Yufan , Wang Hongli , Yue Xiaomin , Li Xiaoqing 
Published: April 2023

AbstractMetastasis is responsible for the majority of deaths among breast cancer patients. Although parallel polyclonal seeding has been shown to contribute to organ-specific metastasis, in the past decade, horizontal cross-metastatic seeding (metastasis-to-metastasis spreading) has also been demonstrated as a pattern of distant metastasis to multiple sites. Bone, as the most frequent first destination of breast cancer metastasis, has been demonstrated to facilitate the secondary dissemination of breast cancer cells. In this review, we summarize the clinical and experimental evidence that bone is a transfer station for the secondary dissemination of breast cancer. We also discuss the regulatory mechanisms of the bone microenvironment in secondary seeding of breast cancer, focusing on stemness regulation, quiescence-proliferation equilibrium regulation, epigenetic reprogramming and immune escape of cancer cells. Furthermore, we highlight future research perspectives and strategies for preventing secondary dissemination from bone.
Telomerase deficiency and dysfunctional telomeres in the lung tumor microenvironment impair tumor progression in NSCLC mouse models and patient-derived xenografts
Authors: Piñeiro-Hermida Sergio , Bosso Giuseppe , Sánchez-Vázquez Raúl , Martínez Paula , Blasco Maria A. 
Published: April 2023

AbstractNon-small cell lung cancer (NSCLC) is a leading cause of cancer death. Tumor progression depends on interactions of cancer cells with the tumor microenvironment. Here, we find increased copy number and mRNA expression of the catalytic subunit of telomerase, TERT, in tumors from NSCLC patients, contributing to a lower survival. Moreover, TERT expression in NSCLC patients from the TCGA cohort is mainly associated to the reduced infiltration of CD8+ T lymphocytes, as well as to increased infiltration of myeloid-derived suppressor cells (MDSCs). We also show that TERT deficiency and dysfunctional telomeres induced by 6-thio-dG treatment in mice reduced lung tumor implantation and vascularization, increased DNA damage response, cell cycle arrest and apoptosis, as well as reduced proliferation, inflammation, lung tumor immunosupression and invasion upon induction of a Lewis lung carcinoma (LLC). Furthermore, 6-thio-dG-treated human NSCLC xenografts exhibited increased telomere damage, cell cycle arrest and apoptosis, as well as reduced proliferation, resulting in a reduced tumor growth. Our results show that targeting telomeres might be an effective therapeutic strategy in NSCLC.
Environmental context-dependent activation of dopamine neurons via putative amygdala-nigra pathway in macaques
Authors: Maeda Kazutaka , Inoue Ken-ichi , Takada Masahiko , Hikosaka Okihide 
Published: April 2023

AbstractSeeking out good and avoiding bad objects is critical for survival. In practice, objects are rarely good every time or everywhere, but only at the right time or place. Whereas the basal ganglia (BG) are known to mediate goal-directed behavior, for example, saccades to rewarding objects, it remains unclear how such simple behaviors are rendered contingent on higher-order factors, including environmental context. Here we show that amygdala neurons are sensitive to environments and may regulate putative dopamine (DA) neurons via an inhibitory projection to the substantia nigra (SN). In male macaques, we combined optogenetics with multi-channel recording to demonstrate that rewarding environments induce tonic firing changes in DA neurons as well as phasic responses to rewarding events. These responses may be mediated by disinhibition via a GABAergic projection onto DA neurons, which in turn is suppressed by an inhibitory projection from the amygdala. Thus, the amygdala may provide an additional source of learning to BG circuits, namely contingencies imposed by the environment.
Observing and braiding topological Majorana modes on programmable quantum simulators
Authors: Harle Nikhil , Shtanko Oles , Movassagh Ramis 
Published: April 2023

AbstractElectrons are indivisible elementary particles, yet paradoxically a collection of them can act as a fraction of a single electron, exhibiting exotic and useful properties. One such collective excitation, known as a topological Majorana mode, is naturally stable against perturbations, such as unwanted local noise, and can thereby robustly store quantum information. As such, Majorana modes serve as the basic primitive of topological quantum computing, providing resilience to errors. However, their demonstration on quantum hardware has remained elusive. Here, we demonstrate a verifiable identification and braiding of topological Majorana modes using a superconducting quantum processor as a quantum simulator. By simulating fermions on a one-dimensional lattice subject to a periodic drive, we confirm the existence of Majorana modes localized at the edges, and distinguish them from other trivial modes. To simulate a basic logical operation of topological quantum computing known as braiding, we propose a non-adiabatic technique, whose implementation reveals correct braiding statistics in our experiments. This work could further be used to study topological models of matter using circuit-based simulations, and shows that long-sought quantum phenomena can be realized by anyone in cloud-run quantum simulations, whereby accelerating fundamental discoveries in quantum science and technology.
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6
Authors: Taha Taha Y. , Chen Irene P. , Hayashi Jennifer M. , Tabata Takako , Walcott Keith , Kimmerly Gabriella R. , Syed Abdullah M. , Ciling Alison , Suryawanshi Rahul K. , Martin Hannah S. , Bach Bryan H. , Tsou Chia-Lin , Montano Mauricio , Khalid Mir M. , Sreekumar Bharath K. , Renuka Kumar G. , Wyman Stacia , Doudna Jennifer A. , Ott Melanie 
Published: April 2023

AbstractAlthough the SARS-CoV-2 Omicron variant (BA.1) spread rapidly across the world and effectively evaded immune responses, its viral fitness in cell and animal models was reduced. The precise nature of this attenuation remains unknown as generating replication-competent viral genomes is challenging because of the length of the viral genome (~30 kb). Here, we present a plasmid-based viral genome assembly and rescue strategy (pGLUE) that constructs complete infectious viruses or noninfectious subgenomic replicons in a single ligation reaction with >80% efficiency. Fully sequenced replicons and infectious viral stocks can be generated in 1 and 3 weeks, respectively. By testing a series of naturally occurring viruses as well as Delta-Omicron chimeric replicons, we show that Omicron nonstructural protein 6 harbors critical attenuating mutations, which dampen viral RNA replication and reduce lipid droplet consumption. Thus, pGLUE overcomes remaining barriers to broadly study SARS-CoV-2 replication and reveals deficits in nonstructural protein function underlying Omicron attenuation.
Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43
Authors: Maroto Irene B. , Costas-Insua Carlos , Berthoux Coralie , Moreno Estefanía , Ruiz-Calvo Andrea , Montero-Fernández Carlos , Macías-Camero Andrea , Martín Ricardo , García-Font Nuria , Sánchez-Prieto José , Marsicano Giovanni , Bellocchio Luigi , Canela Enric I. , Casadó Vicent , Galve-Roperh Ismael , Núñez Ángel , Fernández de Sevilla David , Rodríguez-Crespo Ignacio , Castillo Pablo E. , Guzmán Manuel 
Published: April 2023

AbstractThe type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB1R with various intracellular proteins is thought to alter receptor signaling, the identity and role of these proteins are poorly understood. Using a high-throughput proteomic analysis complemented with an array of in vitro and in vivo approaches in the mouse brain, we report that theC-terminal, intracellular domain of CB1R interacts specifically with growth-associated protein of 43 kDa (GAP43). The CB1R-GAP43 interaction occurs selectively at mossy cell axon boutons, which establish excitatory synapses with dentate granule cells in the hippocampus. This interaction impairs CB1R-mediated suppression of mossy cell to granule cell transmission, thereby inhibiting cannabinoid-mediated anti-convulsant activity in mice. Thus, GAP43 acts as a synapse type-specific regulatory partner of CB1R that hampers CB1R-mediated effects on hippocampal circuit function.
High throughput calculations for a dataset of bilayer materials
Authors: Barik Ranjan Kumar , Woods Lilia M. 
Published: April 2023

AbstractBilayer materials made of 2D monolayers are emerging as new systems creating diverse opportunities for basic research and applications in optoelectronics, thermoelectrics, and topological science among others. Herein, we present a computational bilayer materials dataset containing 760 structures with their structural, electronic, and transport properties. Different stacking patterns of each bilayer have been framed by analyzing their monolayer symmetries. Density functional theory calculations including van der Waals interactions are carried out for each stacking pattern to evaluate the corresponding ground states, which are correctly identified for experimentally synthesized transition metal dichalcogenides, graphene, boron nitride, and silicene. Binding energies and interlayer charge transfer are evaluated to analyze the interlayer coupling strength. Our dataset can be used for materials screening and data-assisted modeling for desired thermoelectric or optoelectronic applications.