bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Terapi Relaksasi Autogenik Untuk Menurunkan Kadar Glukosa Darah Pada Pasien Diabetes Mellitus (DM) Tipe 2 RSUD H. Abdul Manap Kota Jambi
Authors: Ambarwati Ambarwati , Sari Yulia Indah Permata 
Published: January 2025

Diabetes melitus adalah gangguan metabolik yang terjadi pada tubuh, biasanya ditandai dengan adanya peningkatan kadar gula dalam darah. Banyak komplikasi yang dapat terjadi sebagai penyakit penyerta dari diabetes apabila penyakit ini tidak dikendalikan, seperti pada ginjal, jantung, mata, sistem saraf dan sistem pembuluh darah. Tata laksana yang dapat dilakukan untuk mengelola diabetes agar kadar glukosa darah tetap stabil yaitu dengan menerapkan terapi non farmakologis dalam bentuk relaksasi autogenik. Relaksasi autogenik ialah suatu teknik untuk membuat tubuh serta pikiran menjadi lebih rileks. Metode yang dipakai dalam penelitian ini yaitu case report atau desain laporan kasus dalam bentuk pretest dan posttest terapi relaksasi autogenik. Subjek pada penelitian adalah 1 pasien yang mengalami diabetes tipe 2 dengan masalah ketidakstabilan kadar glukosa. Standar Operasional Prosedur (SOP) relaksasi autogenik dan glukometer adalah instrumen yang dipakai di penelitian ini. Pengumpulan data menggunakan analisis deskriptif dengan melakukan pemeriksaan kadar glukosa sebelum dan setelah dilakukannya relaksasi. Hasil penerapan didapatkan bahwa relaksasi autogenik yang dilakukan selama 3 hari berturut dapat menurunkan kadar glukosa sewaktu pada pasien yang mengalami diabetes tipe 2 dengan masalah ketidakstabilan glukosa darah dengan rerata penurunan sebesar 6 mg/dL. Dapat disimpulkan bahwa penerapan relaksasi autogenik dapat menurunkan kadar glukosa darah sewaktu pada pasien DM Tipe 2 sehingga bisa dijadikan sebagai intervensi mandiri dirumah karena sifatnya mudah dan praktis.
Physical Activities Sebagai Faktor Penurunan Anxiety Pada Lansia Di Kota Malang
Authors: Rahayu Hastutiningtyas Wahidyanti , Aisyiyah Puspitarini Nurul 
Published: January 2025

Physical activities yang merupakan gerakan tubuh yang melibatkan otot dan membutuhkan energi, telah diidentifikasi sebagai faktor penting dalam menjaga kesehatan fisik dan mental pada populasi lansia. Kota Malang, yang mengalami pertumbuhan populasi lansia yang signifikan, memiliki potensi untuk menjadi lingkungan yang mendukung aktivitas fisik dengan berbagai fasilitas olahraga dan komunitas yang ada. Namun, faktor-faktor seperti urbanisasi dan tingkat stres yang tinggi di lingkungan perkotaan juga dapat berkontribusi pada tingkat kecemasan yang lebih tinggi pada lansia. Selain itu physical activities merupakan salah satu faktor dalam menurunkan Anxiety pada Lansia. Physical Activities tidak hanya berkontribusi pada ilmu pengetahuan tetapi juga memberikan dampak praktis untuk meningkatkan kualitas hidup lansia di Indonesia. Tujuan dalam penelitian ini adalah mengetahui physical activities sebagai faktor dalam menurunkan anxiety pada lansia. Penelitian menggunakan desain observasi analitik dengan pendekatan cross sectional. Sampel sesuai dengan kriteria inklusi dan eksklusi, ditentukan dengan teknik simple random sampling yaitu sebanyak 50 lansia. Pengumpulan data menggunakan kuesioner physical activity scale for elderly (PASE) untuk physical activity dan untuk anxiety menggunakan kuesioner Skala HARS (Hamilton Anxiety Rating Scale). Analisis dilakukan secara univariat untuk melihat deskriptif statistik data penelitian dan analisis bivariat dengan korelasi spearman rank dengan menggunakan aplikasi SPSS versi 16 uji spearman-rank didapatkan p-value 0,013. Hasil ini menunjukkan bahwa physical activities sebagai faktor menurunkan anxiety pada lansia di Kota Malang
Penyebab Menyontek dan Solusinya
Authors: Irwan Soulisa  , Frenny S. Pormes  , Agustinus G. Gifelem  , Peter Manuputty  , Juneth N. Wattimena  
Published: January 2025

Menyontek merupakan perilaku yang sering dilakukan oleh banyak pelajar semasa mereka mengenyam pendidikan formal. Selama ini, perilaku menyontek kurang mendapatkan perhatian khusus dari berbagai pihak karena dianggap merupakan sebuah tindakan sepele, padahal perilaku ini merupakan salah satu bentuk ketidakjujuran di dalam dunia pendidikan. Penyebab seorang pelajar menyontek tugas atau pekerjaan temannya dapat dipengaruhi oleh faktor internal, maupun eksternal (dari orang tua, guru, ataupun sistem pendidikan yang ada). Secara interal, penyebab seorang pelajar menyontek biasanya muncul dari kurangnya rasa percaya diri dan ketidaksiapan siswa dalam mengahadapi ujian. Sedangkan secara eksternal, menyontek dapat disebabkan oleh tidak adanya variasi dalam proses pengajaran sehingga siswa enggan untuk belajar. PKM ini bertujuan untuk mengedukasi para pelajar agar dapat mengenali potensi yang ada pada dirinya masing-masing sehingga dapat bersikap jujur serta tidak hanya menganggap bahwa nilai adalah segalanya tanpa mengedepankan ilmu yang harus diperoleh.
Penerapan Terapi Storytelling Digital Mengatasi Kecemasan Pada Anak Usia Pra Sekolah
Authors: Sari Ria setia , Ranan Salsabila  
Published: January 2025

Anak-anak yang dirawat di rumah sakit kemungkinan besar merasa cemas. Mereka sering mengalami kecemasan, seperti menangis dan takut pada orang baru, yang dapat menghambat pertumbuhan mereka. Lingkungan rumah sakit juga dapat menyebabkan kecemasan dan stress bermain merupakan kegiatan yang dapat dilakukan anak dengan tujuan untuk merangsang tumbuh kembang anak dan bermain pada anak di rumah sakit merupakan cara anak untuk mengungkapkan perasaannya, rileks dan mengalihkan perasaan yang sulit diekspresikan nya. Storytelling menghubungkan sebuah cerita dengan beberapa penonton atau pendengar melalui suara dan petunjuk, juga dikenal sebagai cerita. Tujuan dari penelitian ini diketahui pengaruh terapi bermain Storytelling digital terhadap tingkat kecemasan pada anak usia prasekolah di Rumah Sakit. Penelitian dilakukan dengan design quasi experiment, Pemilihan sampel dilakukan dengan teknik Total Sampling, sebanyak 55 responden. Analisa data menggunakan uji PreTest–PostTest didapatkan hasil P Value 0,00 yang artinya kesimpulan pada penelitian ini terdapat pengaruh yang signifikan antara pemberian terapi bermain storytelling digital terhadap tingkat kecemasan. Hasil dari penelitian ini di harapkan menjadi sumber rujukan untuk perawat dalam memberikan intervensi pada anak dengan hospitalisasi yang mengalami kecemasan.
Analisis Perilaku Hidup Bersih dan Sehat Siswa Madrasah Aliyah Babul Ulum Mariana
Authors: Dewi Sayati  , Atma Deviliawati  , Nani Sari Murni  
Published: January 2025

Sekolah merupakan salah satu tatanan yang perlu menerapkan PHBS. Dampak yang akan timbul apabila PHBS kurang diterapkan di sekolah dapat berupa penurunan prestasi dan semangat belajar, penurunan citra sekolah, serta suasana belajar yang tidak kondusif akibat lingkungan dan keadaan kelas yang kotor, jajanan yang tidak sehat, serta tidak tertatanya tempat pembuangan sampah. Kondisi tersebut juga akan menimbulkan berbagai macam penyakit. Tujuan dari penelitian ini untuk menganalisis perilaku hidup bersih dan sehat siswa Madrasah Aliyah Babul Ulum. Desain penelitian menggunakan analitik cross sectional. Populasi dalam penelitian ini adalah seluruh siswa/i Madrasah Aliyah Babul Ulum yang berjumlah 82 orang. Besar sampel dalam penelitian ini adalah total populasi, yakni 82 responden. Analisis bivariat dilakukan dengan uji Pearson Correlation, tingkat kepercayaan 95% dan batas kemaknaan dengan nilai ? 0,05. Hasil analisis data menunjukkan bahwa CTPS nilai p 0,018 terhadap PHBS siswa. Mengkonsumsi jajanan sehat di kantin sekolah nilai p 0,147, bebas dari asap rokok nilai p 0,614, dan membuang sampah pada tempatnya nilai p 0,199 terhadap PHBS siswa. Simpulan dalam penelitian menunjukkan adanya pengaruh yang bermakna antara variabel CTPS dengan PHBS Siswa, namun tidak terdapat pengaruh antara variabel mengkonsumsi jajanan sehat di kantin sekolah, bebas dari asap rokok, dan membuang sampah pada tempatnya dengan PHBS siswa.
EDUKASI JAJANAN SEHAT SEBAGAI UPAYA PENCEGAHAN STUNTING PADA ANAK USIA PRASEKOLAH
Authors: Kelrey Fathimah , Mars Clara liem Glorya 
Published: January 2025

Jajanan sehat merupakan bagian dari makanan aman yang bergizi yang memegang peranan penting bagi pertumbuhan dan mencegah terjadinya stunting. Angka kejadian stunting pada Balita termasuk anak usia prasekolah di Indonesia masih cukup tinggi sehingga perlu dicegah karena beresiko terhadap kurangnya pemenuhan nutrisi yang optimal. Untuk mengatasi hal tersebut diperlukan edukasi Kesehatan mengenai jajanan sehat. Tujuan dilakukan kegiatan ini diharapkan anak anak usia prasekolah mempunyai pemahaman tentang jajanan sehat sejak dini. Metode edukasi yang digunakan dalam pengabdian masyarakat ini yaitu ceramah, diskusi, tanya jawab dan menggunakan media lembar balik. Hasil kegiatan ini menunjukkan adanya peningkatan pengetahuan dari peserta tentang jajanan sehat pada anak usia prasekolah di TK Angasa Lanud Pattimura Ambon dibuktikan dengan anak mampu memilih atau membedakan jajanan yang sehat dan jajanan yang tidak sehat. Kesimpulan dari kegiatan ini adalah edukasi jajanan sehat pada anak usia prasekolah melalui penyuluhan kesehatan dapat meningkatkan pengetahuan anak tentang jajanan sehat.
Loading rate, geometry, and damage state influence vertical extraction biomechanics in an ex vivo swine dental model
Authors: Gadzella Timothy J. , Rabey Karyne N. , Doschak Michael R. , Westover Lindsey , Addison Owen , Romanyk Dan L. 
Published: January 2025

IntroductionValidated models describing the biomechanics of tooth extraction are scarce. This study seeks to perform experimental and numerical characterization of vertical tooth extraction biomechanics in swine incisors with imposed vertical extraction loads. Imaging analysis related mechanical outcomes to tooth geometry and applied loading rate. Then, the predictive capabilities of the developed finite element analysis (FEA) models were demonstrated by testing different loading scenarios and validating the results against experimental equivalents.MethodsSimulated vertical extractions were performed on partial swine central incisors (n = 49) and studied for peak extraction force and dental complex stiffness. Post-extraction µCT images were obtained to measure root surface attachment area (RSAA) and observe patterns of periodontal ligament (PDL) rupture. Crosshead force-displacement data was used in an inverse finite element analysis (IFEA) to verify parameters for the PDL in an axisymmetric model of tooth extraction. New force-hold loading protocols were devised in silico and validated in a series of tests on swine incisors to demonstrate the predictive efficacy of the finite element model. Force-hold loading on an initially-damaged PDL was also simulated.ResultsReductions in loading rate and RSAA were found to significantly reduce peak extraction forces by 98N–120 N. Increases in instantaneous stiffness during loading were associated with increases in loading rate. Inverse finite element solutions demonstrated consistent PDL parameters across loading cases. Force-hold loading predicted extraction behaviour with large variance in extraction time. Damage imposed in the FEA model was able to predict experimental results from experiments on similarly-damaged dental complexes.ConclusionThis study presents a comprehensive experimental and numerical characterization of vertical tooth extraction biomechanics employing an ex vivo swine model. The results of these experiments suggest that the axisymmetric FEA model is a powerful tool for predicting a range of conditions and dental complex geometries. The predictive power of the FEA model demonstrated in this study encourages its use in pre-clinical testing and development of new vertical extraction loading schemes for improving clinical outcomes.
Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout
Authors: Yang Bin , Luo Guihu , Nie Tailei , Ban Zhenglan , Ning Quanxin , Zhang Jialin , Liu Xiangru , Lin Yanhua , Xie Xiaochun , Chen Qianyun , Zhong Han , Huang Ying , Liao Pan , Liu Yan , Guo Chenyang , Cheng Chuanxu , Sun Erwei 
Published: January 2025

IntroductionUricase replacement therapy is a promising approach for managing hyperuricemia and gout but is hindered by challenges such as short blood circulation time, reduced catalytic activity, and excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies to enhance therapeutic efficacy and safety.MethodsWe designed and synthesized RBC@SeMSN@Uri, a red blood cell-coated biomimetic self-cascade bioreactor, which encapsulates uricase (Uri) and a selenium-based nano-scavenger (SeMSN) within RBC membranes. This design aims to reduce immunogenicity, extend systemic circulation, and maintain enzymatic activity. In vitro assays were conducted to evaluate biocompatibility, anti-inflammatory effects, and oxidative stress protection. In vivo experiments in hyperuricemia and gout models assessed therapeutic efficacy, biodistribution, and biosafety.ResultsRBC@SeMSN@Uri effectively degraded uric acid (UA) into allantoin and converted H2O2 into water, preventing oxidative damage and inflammation. In vitro assays demonstrated excellent biocompatibility and reduced H2O2-induced inflammatory responses compared to free uricase. In vivo, the bioreactor prolonged circulation time, significantly reduced uric acid levels, alleviated kidney damage, and mitigated symptoms of hyperuricemia and gout. It also targeted inflamed joints, reducing swelling and inflammation in gouty arthritis models.DiscussionThis study presents RBC@SeMSN@Uri as a novel biomimetic strategy for enzyme replacement therapy in hyperuricemia and gout. By integrating uricase and selenium-based nano-scavenger within RBC membranes, the bioreactor addresses key limitations of traditional therapies, offering enhanced stability, reduced immunogenicity, and superior therapeutic efficacy. This platform holds potential for broader applications in protein or antibody delivery for enzyme replacement therapies in other diseases.
Relevance of the GH-VEGFB/VEGFA axis in liver grafts from brain-dead donors with alcohol-associated liver disease
Authors: Micó-Carnero Marc , Rojano-Alfonso Carlos , Maroto-Serrat Cristina , Cutrin Juan Carlos , Casillas-Ramírez Araní , Peralta Carmen 
Published: January 2025

IntroductionGrafts with alcohol-associated liver disease (ALD) subjected to prolonged cold ischaemia from donors after brain death (DBD) are typically unsuitable for transplantation. Here, we investigated the role of growth hormone (GH) in livers with ALD from DBDs and its relationship with vascular endothelial growth factor A (VEGFA) and VEGFB.MethodsLivers from rats fed ethanol for 6 weeks and with brain death (BD) were cold stored for 24 h and subjected to ex vivo reperfusion. Hepatic damage and proliferative and inflammatory parameters were analysed after BD, before graft retrieval, and after reperfusion. Survival was monitored using an in vivo transplantation model.ResultsIn DBDs, the administration of GH, which increased the levels in the intestine but not in the liver, induced the generation of both VEGFA and VEGFB in the intestine and protected against hepatic damage caused by BD before retrieving liver grafts from donors. However, VEGFA was the only factor that protected against damage after cold ischemia and reperfusion, which also increased the survival of the recipients.DiscussionIn conclusion, the signalling pathway and beneficial properties of the GH-VEGFA/VEGFB pathway, in which the intestine-liver axis plays a key role, were disrupted when grafts with ALD from DBDs were retrieved from donors and subjected to cold ischemia and reperfusion.
Clinical features and risk factors of HIV-infected patients with intracerebral hemorrhage: a retrospective study with propensity score matching analysis
Authors: Huang Qiuhui , Chen Shengri , Huang Hua , Deng Xuhui , Cen Gengyu , Wang Miao , Liang Zhijian 
Published: January 2025

PurposeTo investigate the clinical features and risk factors of the human immunodeficiency virus (HIV)-infected patients with intracerebral hemorrhage (ICH).Patients and methodsThe patients with HIV-infected without ICH group were matched to the group of HIV-infected ICH patients. Logistic regression analysis using 1:1 propensity score matching (PSM) was performed to investigate the independent risk factors for ICH in HIV-infected patients. The receiver operating characteristic (ROC) curve was configured to calculate the optimal predictors of ICH in HIV-infected patients.ResultsA total of 59 HIV-infected patients with ICH and 180 HIV-infected patients without ICH were included. A cohort of 118 patients was ascertained utilizing PSM. Multivariate binary logistic regression analysis revealed that drug abuse-related HIV-infected, prolonged prothrombin time (PT), and elevated triglyceride (TG) levels were independent risk factors of ICH in HIV-infected patients. The ROC curve demonstrated that the combined predictor, composed of drug abuse-related HIV-infected, prolonged PT, and elevated TG levels, exhibited the highest area under the curve (AUC), with a cut-off point at 0.426, sensitivity of 78%, and specificity of 81.4%.ConclusionThe present study revealed that a valuable factor combined with drug abuse-related HIV-infected, prolonged PT, and elevated serum TG levels could serve as predictors of ICH in HIV-infected patients.
Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection
Authors: Ma Chunxiang , Jiang Mingshan , Li Jiaxin , Zeng Zhen , Wu Yushan , Cheng Rui , Lin Hao , Pang Jiangmei , Yin Fang , Jia Yongbin , Li Lili , Zhang Hu 
Published: January 2025

BackgroundThe prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure of intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for plasma EBV DNA loads in the diagnosis and outcome prediction of intestinal EBV infection, particularly in cases of primary intestinal lymphoproliferative diseases and inflammatory bowel disease (IBD).MethodsReceiver operating characteristic (ROC) curves were examined to determine suitable thresholds for plasma EBV DNA load in diagnosing intestinal EBV infection and predicting its prognosis.Results108 patients were retrospectively assigned to the test group, while 56 patients were included in the validation group. Plasma EBV DNA loads were significantly higher in the intestinal EBV infection group compared to the non-intestinal EBV infection group (Median: 2.02 × 102 copies/mL, interquartile range [IQR]: 5.49 × 101-6.34×103 copies/mL versus 4.2×101 copies/mL, IQR: 1.07 ×101-6.08×101 copies/mL; P &lt; 0.0001). Plasma EBV DNA levels at 9.21×101 and 6.77×101 copies/mL proved beneficial for the identification and prognostication in intestinal EBV infection, respectively. Values of 0.82 and 0.71 were yielded by the area under the ROC curve (AUC) in the test cohort, corresponding to sensitivities of 84.38% (95% confidence interval [95%CI]: 68.25%-93.14%) and 87.5% (95%CI: 69%-95.66%), specificities of 83.33% (95%CI: 64.15%-93.32%) and 68.09% (95%CI: 53.83%-79.6%), positive predictive values (PPV) of 87.1% (95%CI: 71.15%-94.87%) and 58.33% (95%CI: 42.2%-72.86%), and positive likelihood ratios (LR+) of 5.06 and 2.74 in the validation cohort, respectively. Furthermore, a plasma EBV DNA load of 5.4×102 copies/mL helped differentiate IBD with intestinal EBV infection from primary intestinal EBV-positive lymphoproliferative disorders (PIEBV+LPDs), achieving an AUC of 0.85 within the test cohort, as well as 85% sensitivity (95%CI: 63.96%-94.76%), 91.67% specificity (95%CI: 64.61%-99.57%), 94.44% PPV (95%CI: 74.24%-99.72%), and an LR+ of 10.2 in the validation cohort.ConclusionsPlasma EBV DNA load demonstrates notable potential in distinguishing between different patient cohorts with intestinal EBV infection, although its sensitivity requires further optimization for clinical application.
Prognostic impact of coronary microvascular dysfunction assessed by AMR in acute coronary syndrome patients with chronic kidney disease
Authors: Guo Ziyu , Li Yike , Chen Qiang , Zheng Jingang 
Published: January 2025

BackgroundAngiography-derived microcirculatory resistance (AMR) is proposed as a novel, pressure- temperature-wire-free and less-invasive method to evaluate coronary microvascular dysfunction (CMD). This study aims to examine the prognostic role of CMD assessed by AMR in predicting adverse events in acute coronary syndrome (ACS) patients with chronic kidney disease (CKD).MethodsThis retrospective cohort study included ACS with CKD patients in the China-Japan Friendship Hospital from January 2016 to November 2022. The patients were divided into CMD and non-CMD groups based on AMR values of less than or greater than 250 mmHg*s/m.ResultsA total of 345 eligible patients were included in this study. During a median follow-up of 23.0 months, higher prevalence rate of MACEs (28.3% vs. 15.1%, P = 0.003) and death (20.2% vs. 4.1%, P = 0.001) were observed in the CMD group. In multivariate Cox regression analysis, patients in the group of CMD had a 1.843 times higher hazard ratio (HR) for developing MACEs (HR: 1.843, 95% CI: 1.071–3.174, P = 0.027) and 5.325 times higher HR for developing death (HR: 5.325, 95% CI: 1.979–14.327, P &lt; 0.001) for every 10 mmHg*s/m increment in AMR. The incorporation of AMR improved the predictive accuracy of the GRACE score for MACEs and death.ConclusionThis study indicates that the AMR is significantly related to poor prognosis among patients with ACS and CKD. Furthermore, AMR could improve the predictive power of the GRACE risk score. These results indicated that AMR may serve as a valuable clinical tool for classification, risk stratification or therapy individualization in these patients.
Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study
Authors: Yoo Jung Eun , Lee Dagyeong , Kim Bongseong , Chang Won Hyuk , Jin Sang-Man , Han Kyungdo , Shin Dong Wook 
Published: January 2025

BackgroundAmputation confers disabilities upon patients and is linked to cardiometabolic morbidity and mortality. We aimed to compare the incidence of type 2 diabetes (T2DM) between individuals following amputation with those of the general population.MethodsWe performed a population-based retrospective cohort study using the Nationwide Health Insurance Service database. A total of 21,343 individuals with amputation during 2010–2018 and their 1:3 age- and sex-matched controls was included. We conducted Cox proportional hazard analysis to calculate the risk of T2DM among individuals with amputation.ResultsDuring the 4.2 ± 2.5 year mean follow-up period, there were 912 incident T2DM cases (10.7 per 1,000 person-years) among individuals with amputation. Individuals with amputation had a higher risk for T2DM (adjusted hazard ratio [aHR] 1.11, 95% confidence interval [CI] 1.03–1.20) compared with matched controls. The risks were increased further when accompanied with disability; those with severe disability had a higher risk of T2DM (aHR 1.77, 95% CI 1.20–2.60) than matched controls. Individuals with proximal upper limb amputation (aHR 1.10, 95% CI 1.02–1.18) and proximal lower limb amputation (aHR 3.60, 95% CI 1.50–8.64) had a higher risk of T2DM compared with matched controls.ConclusionsIndividuals with amputation were at significantly greater risk for T2DM than the general population, particularly those with severe disability and proximal amputation. Innovative strategies that improve and support the long-term T2DM risk for severely injured individuals with proximal amputation are warranted.