bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicomponent provider–patient intervention to improve glycaemic control
in Medicaid-insured pregnant individuals with type 2 diabetes: clinical
trial protocol for the ACHIEVE study
Authors: Venkatesh Kartik K , Joseph Joshua J , Swoboda Christine , Strouse Robert , Hoseus Jenelle , Baker Carrie , Summerfield Taryn , Bartholomew Anna , Buccilla Lisa , Pan X , Sieck Cynthia , McAlearney Ann Scheck , Huerta Timothy R , Fareed Naleef 
Published: July 2023

Introduction
Type 2 diabetes (T2D) is one of the most frequent comorbid medical
conditions in pregnancy. Glycaemic control decreases the risk of adverse
pregnancy outcomes for the pregnant individual and infant. Achieving
glycaemic control can be challenging for Medicaid-insured pregnant
individuals who experience a high burden of unmet social needs.
Multifaceted provider–patient-based approaches are needed to improve
glycaemic control in this high-risk pregnant population. Mobile health
(mHealth) applications (app), provider dashboards, continuous glucose
monitoring (CGM) and addressing social needs have been independently
associated with improved glycaemic control in non-pregnant individuals
living with diabetes. The combined effect of these interventions on
glycaemic control among pregnant individuals with T2D remains to be
evaluated.

Methods and analysis
In a two-arm randomised controlled trial, we will examine the
combined effects of a multicomponent provider–patient intervention,
including a patient mHealth app, provider dashboard, CGM, a community
health worker to address non-medical health-related social needs and
team-based care versus the current standard of diabetes and prenatal
care. We will recruit 124 Medicaid-insured pregnant individuals living
with T2D, who are ≤20 weeks of gestation with poor glycaemic control
measured as a haemoglobin A1c ≥ 6.5% assessed within 12 weeks of trial
randomisation or within 12 weeks of enrolling in prenatal care from an
integrated diabetes and prenatal care programme at a tertiary care
academic health system located in the Midwestern USA. We will measure
how many individuals achieve the primary outcome of glycaemic control
measured as an A1c<6.5% by the time of delivery, and secondarily,
adverse pregnancy outcomes; patient-reported outcomes (eg, health and
technology engagement, literacy and comprehension; provider–patient
communication; diabetes self-efficacy; distress, knowledge and beliefs;
social needs referrals and utilisation; medication adherence) and CGM
measures of glycaemic control (in the intervention group).

Ethics and dissemination
The Institutional Review Board at The Ohio State University approved
this study (IRB: 2022H0399; date: 3 June 2023). We plan to submit
manuscripts describing the user-designed methods and will submit the
results of the trial for publication in peer-reviewed journals and
presentations at international scientific meetings.

Trial registration number
NCT05662462
Data-driven modeling and parameter estimation of nonlinear systems
Authors: Kumar Kaushal 
Published: July 2023

Abstract
Nonlinear systems play a significant role in numerous scientific and engineering disciplines, and comprehending their behavior is crucial for the development of effective control and prediction strategies. This paper introduces a novel data-driven approach for accurately modeling and estimating parameters of nonlinear systems utilizing trust region optimization. The proposed method is applied to three well-known systems: the Van der Pol oscillator, the Damped oscillator, and the Lorenz system, which find broad applications in engineering, physics, and biology. The results demonstrate the efficacy of the approach in accurately identifying the parameters of these nonlinear systems, enabling a reliable characterization of their behavior. Particularly in chaotic systems like the Lorenz system, capturing the dynamics on the attractor proves to be crucial. Overall, this article presents a robust data-driven approach for parameter estimation in nonlinear dynamical systems, holding promising potential for real-world applications.

Graphic Abstract
Investigating the connection between generalized uncertainty principle and asymptotically safe gravity in black hole signatures through shadow and quasinormal modes
Authors: Lambiase Gaetano , Pantig Reggie C. , Gogoi Dhruba Jyoti , Övgün Ali 
Published: July 2023

AbstractThe links between the deformation parameter$$\beta $$βof the generalized uncertainty principle (GUP) to the two free parameters$$\hat{\omega }$$ω^and$$\gamma $$γof the running Newtonian coupling constant of the Asymptotic Safe gravity (ASG) program, has been conducted recently in [Phys. Rev. D 105 (2022) 12, 124054. https://doi.org/10.1103/PhysRevD.105.124054] In this paper, we test these findings by calculating and examining the shadow and quasinormal modes of black holes, and demonstrate that the approach provides a theoretical framework for exploring the interplay between quantum gravity and GUP. Our results confirm the consistency of ASG and GUP, and offer new insights into the nature of black holes and their signatures. The implications of these findings for future studies in quantum gravity are also discussed.
Complexities in comparing the impact of costimulatory domains on approved CD19 CAR functionality
Authors: Smith Richard , Shen Rhine 
Published: July 2023

AbstractChimeric antigen receptors (CARs) are engineered to target T cells specifically to tumor cells, resulting in the engineered T cell killing the tumor cell. This technology has been developed to target a range of cancers, with the most notable successes in the treatment of B-cell malignancies where four approved therapies, all targeting CD19, are on the market. These four products differ in the costimulation domains, with axicabtagene ciloleucel (Yescarta) and brexucabtagene autoleucel (Tecartus) both utilizing the CD28 costimulation domain whilst tisagenlecleucel (Kymriah) and lisocabtagene maraleucel (Breyanzi) both utilizing the 4-1BB costimulation domain. There are clearly defined differences in how the CD28 and 4-1BB domains signal, yet it is difficult to ascertain which domain affords a superior mechanism of action given many other differences between these products, including overall CAR architecture and manufacturing methods. Additionally, while in vitro and preclinical in vivo studies have compared CARs with different costimulation domains, it remains a challenge to extrapolate differences observed in this biology across different experimental systems to the overall product performance. While there has been extensive preclinical and clinical work looking at CARs with a variety of targeting domains and architectures, this review will focus on the differences between the four marketed anti-CD19 CAR-Ts, with an additional focus on the impact of hinge and transmembrane domain on CAR activity and interaction with the target cell as well as other proteins on the surface of the T-cell.
Increased human immunodeficiency virus viral load with cerebral infarction due to varicella zoster virus vasculopathy on treatment with bictegravir/emtricitabine/tenofovir alafenamide suspension: a case report and literature review
Authors: Ishikawa Kazuhiro , Kawai Fujimi , Mori Nobuyoshi 
Published: July 2023

Abstract
Background
Varicella-Zoster virus (VZV) vasculopathy occasionally occurs in immunocompromised patients and is difficult to treat. The risk factor and optimal therapy remain unclear. Patients with human immunodeficiency virus (HIV) and dysphagia or difficulty in oral intake receive antiretroviral therapy (ART) suspension. However, there remains little evidence regarding ART suspension.

Case presentation
We experienced a case of a 55-year-old man diagnosed with HIV and severe multiple cerebral infarctions due to VZV vasculopathy. We started on bictegravir/tenofovir alafenamide/emtricitabine (BIC/TAF/FTC) and acyclovir (ACV), and prednisone. He was started on BIC/TAF/FTC suspension because of deteriorated swallowing. The HIV viral load was increased; however, no drug-resistance genes were detected. We successfully treated him with doltegravir/abacavir/lamibudine suspension. We performed two literature reviews of the administration of BIC/TAF/3TC suspension and VZV vasculopathy in patients with HIV. Three cases of BIC/TAF/3TC suspension were considered treatment failures. Recent history of VZV infection and a CD4 count under 200 μL may be risk factors for VZV vasculopathy. The effective treatment may be using steroid and ACV; however, treatment duration could differ.

Conclusions
BIC/TAF/FTC suspension administration may be unstable, and treating ACV and steroid may be optimal therapy for VZV vasculopathy; however, the evidence level is low.
On the complexity of non-binary tree reconciliation with endosymbiotic gene transfer
Authors: Gascon Mathieu , El-Mabrouk Nadia 
Published: July 2023

AbstractReconciling a non-binary gene tree with a binary species tree can be done efficiently in the absence of horizontal gene transfers, but becomes NP-hard in the presence of gene transfers. Here, we focus on the special case of endosymbiotic gene transfers (EGT), i.e. transfers between the mitochondrial and nuclear genome of the same species. More precisely, given a multifurcated (non-binary) gene tree with leaves labeled 0 or 1 depending on whether the corresponding genes belong to the mitochondrial or nuclear genome of the corresponding species, we investigate the problem of inferring a most parsimonious Duplication, Loss and EGT (DLE) Reconciliation of any binary refinement of the tree. We present a general two-steps method: ignoring the 0–1 labeling of leaves, output a binary resolution minimizing the Duplication and Loss (DL) Reconciliation and then, for such resolution, assign a known number of 0s and 1s to the leaves in a way minimizing EGT events. While the first step corresponds to the well studied non-binary DL-Reconciliation problem, the complexity of the label assignment problem corresponding to the second step is unknown. We show that this problem is NP-complete, even when the tree is restricted to a single polytomy, and even if transfers can occur in only one direction. We present a general algorithm solving each polytomy separately, which is shown optimal for a unitary cost of operation, and a polynomial-time algorithm for solving a polytomy in the special case where genes are specific to a single genome (mitochondrial or nuclear) in all but one species. This work represents the first algorithmic study for reconciliation with endosymbiotic gene transfers in the case of a multifurcated gene tree.
CRISPR/Cas12a combined with RPA for detection of T. gondii in mouse whole blood
Authors: Wang Xiaofeng , Cheng Miao , Yang Shuqi , Xing Chen , Li Qian , Zhu Yating , Ji Yongsheng , Du Yinan 
Published: July 2023

Abstract
Background
Toxoplasma gondii is an opportunistic protozoan that is ubiquitous in humans and animals. It can invade any human organ and cause severe diseases, including toxoplasma ophthalmopathy, meningoencephalitis, and liver necrosis. Porcine toxoplasmosis is prevalent in China. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and Cas (CRISPR-Associated Protein) systems are widely used for gene editing and pathogen detection. CRISPR-based diagnostics are molecular assays that have been developed to detect parasites with high sensitivity and specificity.

Methods
This study aimed to establish a combined CRISPR/Cas12a and RPA rapid detection method for T. gondii by targeting the B1 gene and 529 bp repeat element (529 RE). The detection results could be visualized by the fluorescence or lateral flow strips (LFS). The sensitivity and specificity of the method were evaluated, and T. gondii-infected mouse blood was used for detection.

Results
The results indicated that the established method for T. gondii detection was satisfactory, with a detection limit of 1.5 cp/μl for the two loci. Moreover, the B1 gene could detect 1 tachyzoite per reaction, and the 529 RE could detect 0.1 tachyzoite per reaction, consistently with the highly sensitive nested polymerase chain reaction (PCR) results. The method was suitable for strains, including RH, and did not cross-react with other protozoa DNA with similar habits. The T. gondii-infected mouse blood samples were all positive for T. gondii at 1, 3, and 5 days post infection (dpi).

Conclusions
This study established a rapid, sensitive, and time-saving DNA detection method for T. gondii that has the potential to be an alternative tool for T. gondii detection in the field.

Graphical abstract
Unusual presentation of antisynthetase syndrome: a case series and review of the literature
Authors: Estrada-Maya Juan , de los Ángeles Cuellar María , Vargas Lina Patricia , Gómez Carmen Cecilia , Bonilla Andrés , Burgos Pedro Felipe , Bedoya Sergio Alejandro , Oliver María Valentina , Molano Nicolás , Linares Juan Sebastián 
Published: July 2023

AbstractBackgroundAntisynthetase syndrome is an inflammatory myopathy that is characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies. Only 30% of those who suffer from the disease can be identified. We present three Hispanic cases of antisynthetase syndrome with unusual clinical pictures were extended myositis panel results enable disease diagnosis and treatment.Case presentationA 57-year-old Hispanic/Latino female with an erythematous scaly plaque, unresolved fever and non-immune haemolytic anaemia in whom inpatient work-up for fever of unknown origin was positive for anti-PL12 positive myositis extended panel. A 72-year-old Hispanic/Latino male with amyopathic weakness syndrome and mechanic hands in whom impatient work-up was relevant for proximal muscle uptake and anti-PM75 and AntiPL-12 myositis extended panel. And a 67-year-old Hispanic/Latino male with progressive interstitial lung disease and unresolved fever ended in myositis extended panel positive for antiPL-7. After systemic immunosuppressor treatment, patients had favourable clinical and paraclinical responses during outpatient follow-up.ConclusionsThe high variability of the antisynthetase syndrome in these cases demonstrates the importance of identification through an expanded panel and highlights the probability that this is a variable disease and that we need to include emerging molecular tests to promote the timely treatment of patients.
Formation mechanism of copper-gilded coronet ornaments excavated from a Sui or early Tang tomb situated in Xi’an, Shaanxi
Authors: Shao Yanbing , Jiang Fengrui , Yang Junchang , Zhang Quanmin , Lu Xuan , Fu Wenbin , Yu Sumei 
Published: July 2023

Abstract
The formation of the gold layer in mercury gilding occurs through the heating a gold amalgam. As a result, the formation mechanism and technical characteristics of gilded products are closely related to the temperature at which they are heated. In this study, XRD and XPS analysis of a copper-gilded coronet from the Sui or Tang dynasties revealed that Au3Cu was one of the main phases of the gold layer. Therefore, base on the thermodynamic stability of ordered phases like Au3Cu, the estimated heating temperature for this copper-gilded coronet ranged from 240 to 285 ℃. Furthermore, SEM–EDS analysis of the cross-sectional concentration distribution of Cu indicated that the diffusion distance of Cu during heating did not exceed 2 μm. At 240–285 ℃, Cu diffused along the defects of the gold layer, and the diffusion process followed Fick’s second law. Previous research has indicated that the defect path diffusion coefficient of Cu is on the order of 10–12 cm2/s, and the heating time of the gilding process is typically considered to be 15 min. Using the diffusion equation, the calculated diffusion distance of Cu aligned with the diffusion behavior of Cu at 240–285 ℃, confirming the inferred heating temperature range. Additionally, at these temperatures, the gold layer was formed through the solid-state reaction of the gold amalgam and was bonded to the substrate through the diffusion of Cu.
Does ownership structure reduce earnings manipulation practice of Egyptian listed firms? Evidence from a dynamic panel threshold model
Authors: Attia Eman F. , Khémiri Wafa , Mehafdi Messaoud 
Published: July 2023

AbstractThis paper analyzes the nonlinear relationship between corporate ownership structure and income manipulation through accrual-based earnings management in the Egyptian context. To do so, we develop a sample of 78 listed non-financial firms, covering the period 2008–2017. Using the dynamic panel threshold analysis approach (Seo and Shin in J Econom 195: 169–186, 2016), we found a nonlinear relationship between ownership structure and earnings manipulations. This proves the presence of an optimal ownership structure threshold below which the ownership structure generates an entrenchment effect on earnings management. However, above this threshold, the ownership structure has an alignment effect. Certainly, these results confirm the theoretical predictions in relation to managerial ownership, governmental ownership, and earnings management (agency, political and development theories, respectively). These results yield important policy implications. It is recommended to set an optimal threshold of ownership structure to control the firm`s managers. This is likely to avoid earnings management.
Characterization, cellular uptake in Caco-2 cells and physiologically based pharmacokinetic modeling of baicalin-loaded solid lipid nanoparticles
Authors: Ammar Hussein O. , Shamma Rehab N. , Yousry Carol , Elbatanony Rasha S. , Khater Basma , Ghoneim Amira M. 
Published: July 2023

Abstract
Background
Baicalin is a natural compound having intriguing and useful pharmacological properties that may be used alone or in conjunction with other treatments in a variety of therapeutic areas. However, the drug has low aqueous solubility and poor absorption. The aim of this research was to optimize the bioavailability of baicalin through incorporation into solid lipid nanoparticles.

Results
The particle size of the prepared baicalin-loaded solid lipid nanoparticles ranged between 248.2 ± 1.72 nm and 291.9 ± 30.9 nm. The speed, duration of homogenization and the content of both the surfactant and soy lecithin affected the particle size and the entrapment efficiency. The optimized formula showed superiority in drug release over the drug suspension, with biphasic release profile. Cell culture results showed good accumulation of the drug into the Caco-2 cells that increases over time in the case of the optimized formula. Physiologically based pharmacokinetic (PBPK) modeling simulated enhanced bioavailability of the optimized formula, compared to the drug suspension.

Conclusion
Solid lipid nanoparticles have demonstrated potential as cancer therapy nanocarriers. Reduced toxicity, improved drug absorption and flexibility in combining hydrophilic and lipophilic medications are all significant advantages of this system. The PBPK simulation suggested the safety of the optimized BA-SLNs in cancer patients and in geriatric populations.
Child marriage and its association with partner controlling behaviour against adolescent girls and young women in sub-Saharan Africa
Authors: Ahinkorah Bright Opoku , Aboagye Richard Gyan , Okyere Joshua , Seidu Abdul-Aziz , Budu Eugene , Yaya Sanni 
Published: July 2023

Abstract
Background
Child marriage and partner controlling behaviours are culturally seated phenomena in sub-Saharan Africa (SSA). Child marriage refers to any legal or customary union involving a boy or girl below the age of 18. Partner controlling behaviour on the other hand refers to a situation where a sexual partner consistently tries to control their spouse’s behaviours, movements, and social contacts with other people. This study examined the association between child marriage and partner controlling behaviour among adolescent girls and young women (AGYW) in SSA.

Methods
We extracted data from the most recent Demographic and Health Surveys of 26 countries in SSA. Countries whose surveys were conducted from 2010 to 2020 were included in the study. A total of 26,970 AGYW (15–24 years) were included in the study. We used a multilevel mixed-effect binary logistic regression analysis to examine the association between child marriage and partner controlling behaviour.

Results
The average prevalence of child marriage was 55.40% (95% CI: 48.83–61.97). This proportion ranged from 19.62% (95% CI: 16.71–22.53) in South Africa to 85.10% (95% CI: 83.14–87.06) in Chad. The proportion of AGYW who had experienced partner controlling behaviour was 68.36% (95% CI: 64.40–72.33), and this ranged from 38.40% (95% CI: 35.55–41.25) in Burundi to 88.18% (95% CI: 83.80–92.56) in Gabon. AGYW who married as child brides were more likely [aOR = 1.31; 95% CI = 1.21, 1.43] to experience partner controlling behaviour compared to those who did not marry as child brides. AGYW in Western [aOR = 1.51; 95% CI = 1.33, 1.71] and Eastern [aOR = 1.31; 95% CI = 1.13, 1.50] part of SSA were more likely to experience partner controlling behaviour compared to those in Central Africa.

Conclusions
Our study has shown that there is a significant association between child marriage and the likelihood of experiencing partner controlling behaviour in SSA. Effective policies and interventions are, therefore, needed to prevent child marriage and raise AGYW’s awareness of its implication on victims of partner controlling behaviours.
Barbaren, Asiaten, Sklaven, Juden. Rassismus in der Antike?
Authors: Meyer-Zwiffelhoffer Eckhard 
Published: July 2023

Zusammenfassung
Der Aufsatz geht der Frage nach, ob es in der griechischen und römischen Antike Vorstellungen, Handlungsweisen oder gesellschaftliche und politische Strukturen gegeben hat, die als „rassistisch“ zu bezeichnen wären. Das Problem einer solchen Untersuchung besteht darin, dass in der Forschung keine Einigkeit darüber herrscht, was unter „Rassismus“ zu verstehen sei: Dominierten bis in die späten 1960er Jahren Konzeptionen, die auf einem biologischen Rassenbegriff beruhten, so wurden seither zahlreiche Theorien formuliert, die von einem kulturalistischen Verständnis des Phänomens im Sinne eines „Rassismus ohne Rassen“ ausgehen und tendenziell jegliche soziale und politische Diskriminierung – etwa aufgrund von Herkunft, Religion, Klasse, Geschlecht, Hautfarbe – als „rassistisch“ begreifen. Im ersten Teil des Aufsatzes zeichne ich die Geschichte des Rassismusbegriffs nach und entwickele eine eigene Konzeption, deren Kriterien es erlauben, kultur- und epochenübergreifend festzustellen, welche Verhältnisse wir zu Recht rassistisch nennen können, ohne zugleich jede Form von Diskriminierung als solche zu bezeichnen. Im zweiten Teil des Aufsatzes untersuche ich dann vier antike Phänomene, die in der modernen Forschung unter Rassismusverdacht stehen, unter dem Aspekt, ob hier sinnvollerweise von „Rassismus“ zu sprechen wäre: die griechische und römische Barbarenkonzeption, die sogenannte hippokratische Umwelttheorie, Aristoteles’ Theorem des „Sklaven von Natur“ und die antike Judenfeindschaft.