bluuebunny/crossref_metadata_2025_split huggingface dataset:
Control of particle growth and enhancement of photoluminescence, adsorption efficiency and photocatalytic activity for zinc sulfide and cadmium sulfide using CoAl-layered double hydroxide system
Authors: Intachai Sonchai , Sumanatrakul Panita , Khaorapapong Nithima 
Published: January 2023

Abstract

The fabrication of zinc sulfide (ZnS) and cadmium sulfide (CdS) hybrids was carried out by the sulfidization of Zn(II) or Cd(II) adsorbed in dodecylsulfate modified CoAl-layered double hydroxide through solid-liquid reaction. The TEM images showed the nanocrystals of ZnS (2.61 nm) or CdS (3.29 nm) that orderly distributed on the nanosheets. The spectroscopic observations further confirmed the formation of ZnS or CdS nanoparticles in the hybrid as the evidence of the blue-shifted absorption onset, and the increase of the photoluminescence intensity relative to those of bare ZnS and CdS. In addition, the host-guest and/or guest-guest interactions promoted the greater optical performance, and adsorption and photocatalytic efficiencies. This research showed an interesting process for controlling the small nanoparticles of ZnS and CdS by intercalating in the interlayer space of CoAl-layered double hydroxide in the helping of dodecylsulfate, and for enhancing their photoluminescence intensity and performance for long time-period. Besides, the nanohybrids could be applicable as the adsorbent and photocatalyst on purifying wastewater contaminated with Congo red dye.
Analysis of the technological process of welding a membrane wall with Inconel 625 nickel alloy
Authors: Majerik Jozef , Slany Martin , Chochlikova Henrieta , Sedlak Josef , Zouhar Jan , Zemcik Oskar , Barenyi Igor , Kolomy Stepan 
Published: January 2023

Abstract
Research carried out by the authors of this paper is focused on the technological process of Inconel 625 welding with the MAG - CMT method. Inconel 625 was welded on the substrate material, which was 16Mo3 steel. Both materials are used to produce so-called bimetallic tubes, which in practice serve as part of the equipment intended for waste incineration. For this reason, the bimetallic tubes have to withstand extreme conditions during their operation. Therefore, bimetal pipes are highly stressed composite components that must resist corrosion in a chemically aggressive environment. For this reason, an extensive material and technological analysis of the production of pipe bends with a supercritical bend of 0.7D from bimetal pipes with Inconel 625 cladding was performed. In the welding process, the authors investigated the possibilities of the CMT method with and without divergence. The most important factor in deciding which method would be appropriate was to measure the amount of iron on the surface of the coating layer. The authors' paper builds on the authors' previous research in this area, which was mainly focused on research on critical bending of bimetallic tubes.
Disposal of household medications: practices and attitudes of pharmacists when dispensing medication
Authors: Michelin Aparecida de Fatima , Bonifácio Neuza Alves , Nagata Walter Bertequini , Silva Valéria Maria Savoya da , Gobbo Laura Emilia Michelin , Bresciani Katia Denise Saraiva 
Published: January 2023

Abstract
Background: Discarding pharmaceuticals in the garbage or into the sewage system are still the most common methods in many countries. This study aims to investigate the guidance provided by pharmacists to customers on the disposal of unused and expired household medications in São Paulo State, Brazil.
Method: The study population consisted of 630 pharmacists from the State of São Paulo, the majority were women under 60 years old, who work in pharmacies that dispense commercial drugs. They answered an online questionnaire with questions composed in three blocks: demographic, work, and academic information on the pharmacist; the disposal of household medications; and the reverse logistics of these medications. An invitation to participate in the questionnaire was made via WhatsApp, individually and collectively. Inferential statistics were performed using the chi-square test, and were considered significant when p<0.05%.
Results: Among the participating pharmacists, 56 (8.89%) and 216 (34.28%), respectively, stated that they rarely or never orient the customer regarding the disposal of unused and expired household medications, while 199 (31.59%) and 159 (25.24%), respectively, indicated that they almost always or always provide guidance. The frequency with which they provided guidance was influenced by the number of years since graduation (p=0.0047), the time they had worked in pharmacies and drugstores (p=0.0007), and whether or not they had a graduate degree (p=0.0181). Regarding the disposal of medications, among the 643 responses provided by the pharmacists, 516 (80.25%) indicated that they oriented customers to return them to a pharmacy.
Conclusion: A small number of pharmacists always orient customers on the proper disposal that should be followed for unused and expired household medications, prioritizing their return to a pharmacy. In general, these pharmacists have longer periods of work experience and higher academic qualifications. Thus, it is important to increase knowledge through professional training and further education programs.
Guidance for dysmorphic sacrum fixation with upper sacroiliac screw based on imaging anatomy study: techniques and indications
Authors: Shan Tan , Hanqing Li , Qiuchi Ai , Junchao Xing , Meitao Xu , Tianyong Hou , Shichang Gao 
Published: January 2023

Abstract
Objective: This study aimed to investigate the techniques and indications of upper sacroiliac screw fixation for the dysmorphic sacrum.
Methods: The dysmorphic sacra were selected from 267 three-dimensional pelvic models. The dysmorphic sacra which couldn’t accommodate a 7.3 mm upper trans ilio-sacroiliac screw were classified as the main dysmorphic sacra. Then, the size of the bone corridor, the length of the screw in the corridor, and the orientation of the screw were measured. The insertion point on the sacrum was identified by two bone landmarks.
Results: totally, 30.3% of sacra were identified as the main dysmorphic sacra. The inclinations of the screw oriented from posterior to anterior were (21.80±3.56)° for males and (19.97±3.02)° for females (p<0.001), and from caudal to cranial were (29.97±5.38)° for males and (28.15±6.21)° for females (p=0.047). The min diameters of the corridor were (16.31±2.40) mm for males and (15.07±1.58) mm for females (p<0.001). The lengths of the screw in the Denis Ⅲ zone were (14.41±4.40) mm for males and (14.09±5.04) mm for females (p=0.665), and in the Denis Ⅱ+Ⅲ zones were (36.25±3.40) mm for males and (38.04±4.60) mm for females (p=0.005). The rates of LP-PSIS/LAIIS-PSIS were (0.36±0.04) for males and (0.32±0.03) for females (t=4.943, p<0.001). The lengths of LPM were (8.81±5.88) for males and (-4.13±6.33) for females (t=13.434, p<0.001).
Conclusion: When the sacrum has the features of “sacrum not recessed” and/or “acute alar slope”, the conventional trans ilio-sacroiliac screw couldn’t be placed safely. The inclination oriented from posterior to anterior and from caudal to cranial are approximately 20° and 30°, respectively. The bone insertion point locates in the rear third of the anterior inferior iliac spine to the posterior superior iliac spine. The sacroiliac screw is not recommended to fix the fractures in Denis Ⅲ zone.
Association of image-defined risk factors with clinical features, tumor biology, and outcomes in neuroblastoma: a single-center retrospective study
Authors: Yang Dan-dan , Liu Chuan , Jin Gao , Hu Qiao-jun , Liang Yong , Liu Jian 
Published: January 2023

Abstract
Background
Image-defined risk factors (IDRF) in neuroblastoma have been developed to predict tumor resectability and surgical complications; however, the potential prognostic value of IDRF in neuroblastoma has been variably reported. Previous studies did not report the IDRF status separately from the International Neuroblastoma Risk Group (INRG) stage. Moreover, the association between IDRF and clinical and pathological factors has not been discussed further.
Methods
In this retrospective study, we investigated the clinical and biological features of neuroblastoma at different INRG stages based on IDRF. Event-free survival (EFS) and overall survival (OS) related to the INRG stage were analyzed using log-rank tests, and the prognostic value of the IDRF number and type was also evaluated.
Results
Among 72 patients, 182 IDRF at diagnosis were found in 79.2%. The distribution of the INRG stages was 10 L1 (13.9.0%), 25 L2 (34.7%), and 37 M/MS (51.4%). Patients with stage M/Ms had a larger tumor volume, a higher percentage of age ≥ 18 months, elevated lactate dehydrogenase (LDH) level, elevated ferritin level, and a higher percentage of COG high-risk compared with stage L1 and L2 patients. EFS and OS were similar for stage L1 and L2 tumors but were significantly poorer for metastatic disease. However, EFS (P = 0.06) and OS (P = 0.07) were similar for IDRF-negative and positive neuroblastomas. Patients with stage M/Ms with IDRF-positive had poorer EFS (P = 0.001) and OS (P < 0.001) compared with patients in stage L2. An IDRF ≥ 4, vascular IDRF, and infiltrative IDRF of the tumor were significant indicators of poor prognosis.
Conclusions
Our study indicates that increasing the INRG stages based on IDRF is associated with various unfavorable clinical features of neuroblastoma. The principal determinant of survival in neuroblastoma is the presence of metastatic disease more than IDRF alone at diagnosis. Both the number and type of IDRF have important clinical significance in the protocol planning of neuroblastoma, rather than just considering the absence or presence of IDRF.
Impact of Perfusion Modalities on Cerebral Hemodynamics, Organ Injury, and Clinical Outcomes in Acyanotic and Cyanotic Congenital Heart Surgery Patients
Authors: Patel Krishna , Lin Tracie K. , Clark Joseph B. , Ceneviva Gary D. , Imundo Jason R. , Spear Debra , Kunselman Allen R. , Thomas Neal J. , Myers John L. , Undar Akif 
Published: January 2023

Abstract
Background: Acyanotic and cyanotic congenital heart disease (CHD) patients are known to have distinct operative risk profiles. However, little is known about whether pulsatile and non-pulsatile cardiopulmonary bypass (CPB) have differential effects on cerebral hemodynamics or outcomes in these two patient groups.
Methods: 159 pediatric (age <18 years) cardiac surgery patients were randomized to pulsatile or non-pulsatile CPB. Patients were stratified by type of CHD: acyanotic versus cyanotic. Intraoperative cerebral gaseous microemboli counts and middle cerebral artery pulsatility index were assessed. Postoperative organ injury was quantified by Pediatric-Logistic-Organ-Dysfunction (PELOD-2) score at 24, 48, and 72 hours. Additional outcomes included Pediatric Risk-of-Mortality 3 (PRISM 3) score, vasoactive-inotropic score, duration of mechanical ventilation, intensive care and hospital length-of-stay, and mortality within 180 days.
Results: Regional-cerebral-oxygen-saturation, gaseous microemboli counts, and mean arterial pressure were similar between groups. PELOD-2 scores decreased over time, with similar scores between perfusion modalities in either group. Analysis of additional postoperative outcomes revealed no significant differences between non-pulsatile and pulsatile perfusion in either acyanotic or cyanotic groups.
Conclusions: Despite patients undergoing pulsatile CBP demonstrating a more physiologic pulsatility index in both acyanotic and cyanotic groups, no clinically significant differences in cerebral hemodynamics or clinical outcomes were appreciated.
Trial Registration Number and Registration Date: NCT00862407 (16/03/2009) (first registration date)
Condensed tannins mediate the effect of long-term nitrogen addition on soil nematodes in a boreal spruce forest
Authors: Tonjer Lea-Rebekka , Nybakken Line , Birkemoe Tone , Renčo Marek , Ferdous Zannatul , Asplund Johan 
Published: January 2023

Abstract
Fertilization and combustion have increased nitrogen (N) deposition over the last decades. Most boreal forests are N limited; thus, increased N availability may have considerable implications for boreal forest food web structure and functioning. Soil biota are important drivers of ecosystem processes through their effect on carbon (C) and nutrient cycling. Among these, nematodes are ubiquitous in soil and respond quickly to environmental changes. They are thus useful in determining changes in ecosystem status. Boreal forest plants produce large quantities of condensed tannins (hereafter tannins), and these may decrease following N addition. As defence compounds, tannins may alter soil community structure by reducing microbial activity and deter microfauna. Using nematodes as indicators, we here investigated the linkages between N-induced changes in soil food web and soil tannin concentration. We utilized a fertilization experiment where plots have been fertilized since 2003 at a rate of 150 kg ha− 1 yr− 1 in the form of granulated pellets containing 24.6% N, 2% P, 6% K and trace elements. This have resulted in a shift in the understory, and consequently a decrease in soil tannin concentration. Fertilization led to a less structured nematode community dominated by bacterivores. The abundance of bacterivores relative to fungivores increased, indicating a more bacteria-dominated energy channel. Furthermore, the dominance of bacteria appears to have been inhibited by soil tannin concentrations in the fertilized plots. Overall, our study demonstrate that soil community structure strongly changes upon increased N availability, and lower soil tannin concentrations further facilitate the dominance of bacteria.
Serum TSP-2 levels are elevated in type 2 diabetes mellitus and are independently associated with early diabetic kidney disease
Authors: Lin Zhenzhen , Zhang Yingchao , Liu Zhen , Guo Wanxie , Bi Yanxue , Wu Maolan , Zhang Xinxin , Zhang Didong , Lin Zhuofeng , Lu Xuemian 
Published: January 2023

Abstract
OBJECTIVE Thrombospondin-2 (TSP-2) is a multifunctional matricellular glycoprotein correlated with glucose homeostasis, insulin sensitivity, and estimated glomerular filtration rate. Investigation of the association of TSP-2 with type 2 diabetes mellitus (T2DM) and the potential diagnostic value of serum TSP-2 for detecting early diabetic kidney disease (DKD) is needed.
RESEARCH DESIGN AND METHODS An enzyme-linked immunosorbent assay was used for detection serum TSP-2 levels in 494 Chinese T2DM subjects. The protein expression of TSP-2 in the kidney and other tissues were tested by western blotting.
RESULTS of Serum TSP-2 levels in T2DM subjects were significantly higher than in healthy individuals. Serum TSP-2 correlated positively with triglycerides, serum uric acid, creatinine, platelets, and urinary albumin-to-creatinine ratio (UACR), but negatively with estimated glomerular filtration rate, after adjusting for age, sex, and T2DM duration. Logistic regression analysis demonstrated an independent association between serum TSP-2 and early DKD. Furthermore, the high UACR identified at risk of early DKD increased significantly from 0.78 (95%CI 0.73-0.83) to 0.82 (95%CI 0.77-0.86, p< 0.001) when added to a clinical model consisting of TSP-2 and age. In db/db mice, serum TSP-2 levels were elevated. TSP-2 expression was markedly increased in the kidney tissue compared with that in db/m and m/m mice. Furthermore, serum TSP-2 expression correlated well with UACR in mice.
CONCLUSIONS TSP-2 is a novel glycoprotein associated with early DKD in patients with T2DM. The paradoxical increase of serum TSP-2 in T2DM individuals may be due to a compensatory response to chronic inflammatory and renal vascular endothelial growth, warranting further investigation.
Inframalleolar thrice distal puncture in a single endovascular treatment session for successful revascularization
Authors: Ota Issei , Nomura Tetsuya , Ono Kenshi , Sakaue Yu , Shoji Keisuke , Wada Naotoshi 
Published: January 2023

Abstract
Background: Infrapopliteal arterial diseases are prevalent in critical limb threatening ischemia (CLTI) populations and are often challenging to treat. In endovascular treatment (EVT) for those complex lesions, establishing retrograde access is an essential option not only for guidewire crossing but also for device delivery. However, there has been no EVT case report requiring inframalleolar thrice distal puncture in a single EVT session so far.
Case presentation: A 60-year-old CLTI patient whose WIfI classification was stage 3 underwent EVT for occluded dorsal artery and posterior tibial artery. Firstly, we conducted successful balloon angioplasty of the posterior tibial artery by establishing a retrograde approach via the lateral plantar artery. To treat the occlusion of dorsal artery, we retrogradely punctured the first dorsal metatarsal artery and retrogradely advanced a guidewire to the dorsal artery occlusion; however, the microcatheter could not follow the guidewire. Therefore, we punctured the occluded dorsal artery and introduced the retrograde guidewire into the puncture needle. After guidewire externalization, we pulled up the retrograde microcatheter into the occlusion of dorsal artery using the “balloon deployment using forcible manner” technique. Thereafter, we were able to advance the antegrade guidewire into the retrograde microcatheter. After guidewire externalization, an antegrade balloon catheter was delivered and inflated for the purpose of dorsal artery dilation and hemostasis at the dorsal artery puncture site. Successively, balloon dilation was performed to hemostat the puncture site of the first dorsal metatarsal artery and complete hemostasis was achieved. Finally, we confirmed good vascular patency and favorable blood flow. After revascularization, transmetatarsal amputation was performed and the wound healed favorably.
Conclusions: We can markedly increase the success rate of revascularization by better utilizing the retrograde approach in EVT for complex chronic total occlusions in infrapopliteal arterial diseases.
Duodenal-jejunal bypass surgery activates eNOS and enhances antioxidant system by activating AMPK pathway to improve oxidative stress diabetic cardiomyopathy
Authors: yang guangwei , Zhao Xiang , Liu Zitian , Ge Zheng , Yao Lunjin , Cheng Zhiqiang , Wang Xiaoyang , Zhang Xiang , Wang Kexin 
Published: January 2023

Abstract
Background: Diabetic cardiomyopathy (DCM) is a serious complication of Obesity with type 2 diabetes. Bariatric surgery can effectively improve DCM; however, the underlying mechanisms remain elusive. Our objective was to investigate the effect and potential mechanisms of duode-nal-jejunal bypass (DJB) on oxidative stress in the heart.
Methods: DJB was performed on DCM rats, and high glucose (HG) and palmitate (PA) were used to simulate DCM in H9C2 cells in vitro. AMPK agonists and inhibitors were used to verify the role of the AMPK pathway. Serum from different groups of rats was used to verify that the im-provement in DCM after DJB surgery was not strictly owing to improvement in blood glucose levels and connect the experiments in vivo and in vitro.
Results: DJB surgery effectively improved oxidative stress and increased expression of the AMPK pathway, p-eNOS/eNOS, NRF2, HO-1, and SOD2 in terms of protein and mRNA in the heart of DCM rats. Compared to H9C2 cells in the HG+PA environment alone, the addition of either AMPK agonists or serum from DJB rats increased the expression of the AMPK pathway, p-eNOS/eNOS, NRF2, HO-1, and SOD2 in terms of protein and mRNA and decreased the content of ROS, but this improvement was almost eliminated by the addition of AMPK inhibitors.
Conclusions: Therefore, DJB surgery can improve oxidative stress in the heart of DCM rats, which may be achieved by activating the AMPK pathway, thereby increasing the phosphorylation level of eNOS, increasing NO and reducing ROS production, and improving the antioxidant system and not solely the improvement of blood glucose.
Fructose-1,6-bisphosphatase deficiency: estimation of prevalence in the Chinese population and analysis of genotype-phenotype association
Authors: Ni Qi , Tang Meiling , Chen Xiang , Lu Yulan , Wu Bingbing , Wang Huijun , Zhou Wenhao , Dong Xinran 
Published: January 2023

Abstract
Background
Fructose-1,6-bisphosphatase deficiency (FBP1D) is a rare inborn error due to mutations in the FBP1 gene. The genetic spectrum of FBP1D in China is unknown, also nonspecific manifestations confuse disease diagnosis.
Materials & Methods
We collected 101 FBP1 variants from our cohort and public resources, and manually curated pathogenicity of these variants. Ninety-seven pathogenic or likely pathogenic variants were used in our cohort to estimate Chinese FBP1D prevalence by three methods: 1) carrier frequency, 2) permutation and combination, 3) Bayesian framework. Allele frequencies (AFs) of these variants in our cohort, China Metabolic Analytics Project (ChinaMAP) and gnomAD were compared to reveal the different hotspots in Chinese and other populations. Clinical and genetic information of 122 FBP1D patients from our cohort and published literature were collected to analyze the genotype-phenotypes association. Phenotypes of 68 hereditary fructose intolerance (HFI) patients from our previous study were used to compare the phenotypic differences between these two fructose metabolism diseases.
Result
The estimated Chinese FBP1D prevalence was 1/1,310,034. In the Chinese population, c.490G > A and c.355G > A had significantly higher AFs than in the non-Finland European population, and c.841G > A had significantly lower AF value than in the South Asian population (all P values < 0.05). The genotype-phenotype association analyses showed that patients carrying homozygous c.841G > A were more likely to present increased urinary glycerol, carrying two CNVs (especially homozygous exon1 deletion) were often with hepatic steatosis, carrying two missense variants were not likely to present fever, carrying compound heterozygous variants were usually with lethargy, and carrying homozygous variants were usually with ketosis and hepatic steatosis (all P values < 0.05). By comparing to phenotypes of HFI patients, FBP1D patients were more likely to present hypoglycemia, metabolic acidosis, and seizures (all P value < 0.05).
Conclusion
The prevalence of FBP1D in the Chinese population is extremely low. Genetic sequencing could effectively help to diagnose FBP1D.