bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of the eHealth decision support tool, MIPOGG, for recognising children with Li-Fraumeni, DICER1, Constitutional mismatch repair deficiency and Gorlin syndromes
Authors: Hebert Robyn , Cullinan Noelle , Armstrong Linlea , Blood Katherine A , Brossard Josee , Brunga Ledia , Cacciotti Chantel , Caswell Kimberly , Cellot Sonia , Coltin Hallie , Deyell Rebecca J , Felton Kathleen , Fernandez Conrad V , Fleming Adam J , Gibson Paul , Hammad Rawan , Jabado Nada , Johnston Donna L , Lafay-Cousin Lucie , Larouche Valérie , Leblanc-Desrochers Cassandra , Michaeli Orli , Perrier Renee , Pike Meghan , Say Jemma , Schiller Ian , Toupin Annie-Kim , Vairy Stéphanie , van Engelen Kalene , Waespe Nicolas , Villani Anita , Foulkes William D , Malkin David , Reichman Lara , Goudie Catherine 
Published: July 2023

BackgroundCancer predisposition syndromes (CPSs) are responsible for at least 10% of cancer diagnoses in children and adolescents, most of which are not clinically recognised prior to cancer diagnosis. A variety of clinical screening guidelines are used in healthcare settings to help clinicians detect patients who have a higher likelihood of having a CPS. The McGill Interactive Pediatric OncoGenetic Guidelines (MIPOGG) is an electronic health decision support tool that uses algorithms to help clinicians determine if a child/adolescent diagnosed with cancer should be referred to genetics for a CPS evaluation.MethodsThis study assessed MIPOGG’s performance in identifying Li-Fraumeni, DICER1, Constitutional mismatch repair deficiency and Gorlin (nevoid basal cell carcinoma) syndromes in a retrospective series of 84 children diagnosed with cancer and one of these four CPSs in Canadian hospitals over an 18-year period.ResultsMIPOGG detected 82 of 83 (98.8%) evaluable patients with any one of these four genetic conditions and demonstrated an appropriate rationale for suggesting CPS evaluation. When compared with syndrome-specific clinical screening criteria, MIPOGG’s ability to correctly identify children with any of the four CPSs was equivalent to, or outperformed, existing clinical criteria respective to each CPS.ConclusionThis study adds evidence that MIPOGG is an appropriate tool for CPS screening in clinical practice. MIPOGG’s strength is that it starts with a specific cancer diagnosis and incorporates criteria relevant for associated CPSs, making MIPOGG a more universally accessible diagnostic adjunct that does not require in-depth knowledge of each CPS.
Exploring the ChatGPT platform with scenario-specific prompts for vaping cessation
Authors: Amin Samia , Kawamoto Crissy Terawaki , Pokhrel Pallav 
Published: July 2023

ObjectiveTo evaluate and start a discussion on the potential usefulness of applying Artificial Intelligence (AI)-driven natural language processing technology such as the ChatGPT in tobacco control efforts, specifically vaping cessation.MethodTen real-world questions about vaping cessation were selected from a Reddit forum and used as ChatGPT prompts or queries. Content analysis was performed on the ChatGPT responses to identify the thematic aspects of vaping cessation support represented in the responses. Next, the responses were empirically evaluated by five experts in tobacco control on accuracy, quality, clarity, and empathy.ResultThe following themes related to vaping cessation support were identified: understanding nicotine withdrawal symptoms, self-regulation, peer support, motivational support, and Nicotine Replacement Therapy (NRT). The experts judged the ChatGPT responses to be 'satisfactory' to 'excellent' in areas of accuracy, quality, clarity, and empathy.ConclusionIf managed by a group of experts, including clinicians, and behavioral and computer scientists, a platform such as the ChatGPT may be leveraged to design tailored interventions for tobacco use cessation, including vaping cessation.
Comparative analysis of the effect of hypoxia in two different tumor cell models shows the differential involvement of PTEN control of proangiogenic pathways
Authors: Majewska Aleksandra , Brodaczewska Klaudia , Filipiak-Duliban Aleksandra , Kieda Claudine 
Published: July 2023

Hypoxia, low, non-physiological oxygen tension is a key regulator of tumor microenvironment, determining the pathological tumor vascularization. Alleviation of hypoxia through vessel normalization may be a promising therapeutic approach. We aimed to assess the role of low oxygen tension in PTEN-related pathways and proangiogenic response, in vitro, in two different tumor cell lines, focusing on potential therapeutic targets for tumor vessel normalization. Downregulation of PTEN in hypoxia mediates the activation of distinct mechanisms: cytoplasmic pAKT activation in melanoma and pMDM2 modulation in kidney cancer. We show that hypoxia-induced proangiogenic potential was stronger in Renca cells than B16 F10—confirmed by a distinct secretory potential and different ability to affect endothelial cells functions. Therefore, the impact of hypoxia on PTEN-mediated regulation may determine the therapeutic targets and effectiveness of vessel normalization and intrinsic characteristics of cancer cell have to be taken into account when designing treatment.
Non-destructive exploration of late Gothic panel painting using X-ray tomography and flattening of the reconstructed data
Authors: Vavřík Daniel , Antušková Václava , Chlumská Štěpánka , Kumpová Ivana , Šefců Radka , Vopálenský Michal 
Published: July 2023

AbstractThe use of computed tomography (CT) for studying artwork has a long tradition in the restoration and care of collections in memory institutions. The result of the related tomographic reconstruction is a virtual spatial model in which we can examine the production technology, the internal structure, various damaged areas, and previous restoration interventions. The extension of standard CT to dual energy CT provides additional information to help distinguish materials with similar densities but different chemical compositions. As will be shown, pigment differences that appear very similar in optical light can be identified in this way. The differences found were confirmed by X-ray fluorescence and Raman spectroscopy analytical techniques. Current laboratory CT scanners make it possible to examine the layered structures of paintings and polychrome sculptures. In the case of wood panel paintings, however, we are faced with the common deformation of the panels. So, when examining the CT data, we can only see a small section of the paint layer, and it is difficult to examine the whole artwork in its entire context. This disadvantage can be solved by a virtual straightening of the panel, as will be demonstrated.
A Neo-Copenhagen Quantum Mechanics
Authors: Lindblad Göran 
Published: July 2023

An analysis of the quantum measurement problem is presented which is a modest modification of the standard one often called the Copenhagen interpretation. The starting assumption is that QM is universal, and that all evolutions are unitary. We must also assume that the set of evolutions is restricted to allow the existence of stable structures for the equipment in our laboratory, including the measurement devices. The devices need some macroscopic properties to make the outcomes of the experiments stable data. There should not exist superdevices capable of retrieving the information needed to reverse these evolutions. As a result the quantum coherences complementary to the outcomes of experiments will typically be inaccessible and there is no need to remove them by decoherence. We need devices designed such that the outcome of an experiment is indicated by a pointer with the property that it has a definite but random final state. We then find that the outcomes of experiments can be considered factual data, and random in a classical sense. They can be considered to happen in a single world.
Supplementary Table 1 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer
Authors: Moutafi Myrto , Koliou Georgia-Angeliki , Papaxoinis George , Economopoulou Panagiota , Kotsantis Ioannis , Gkotzamanidou Maria , Anastasiou Maria , Pectasides Dimitrios , Kyrodimos Efthymios , Delides Alexander , Giotakis Evangelos , Papadimitriou Nikolaos G. , Panayiotides Ioannis G. , Perisanidis Christos , Fernandez Aileen I. , Xirou Vasiliki , Poulios Christos , Gagari Eleni , Yaghoobi Vesal , Gavrielatou Niki , Shafi Saba , Aung Thazin Nwe , Kougioumtzopoulou Andromachi , Kouloulias Vassilis , Palialexis Konstantinos , Gkolfinopoulos Stavros , Strati Areti , Lianidou Evi , Fountzilas George , Rimm David L. , Foukas Periklis G. , Psyrri Amanda 
Published: July 2023

<p>Supplementary Table 1a. Representativeness of Study Participants

Supplementary Table 1b. Nanostring IO360 panel</p>
Analyzing photovoltaic module mechanics using composite plate theories and finite element solutions
Authors: Hartley James Y , Khraishi Tariq 
Published: July 2023

Deflection and stress calculated from an experimentally validated, high-fidelity finite element model (FEM) of a photovoltaic module experiencing mechanical load was compared to results from a simplified FEM treating the module laminate as a homogenized composite using a rule of mixtures approach, and further compared to analytical calculations treating the module as a Kirchoff-Love flat plate. The goal of this study was to determine the error incurred by analyzing module mechanics with varying levels of simplification, since resolving the aspect ratios of a module is computationally expensive. Homogenized FEMs were found to underpredict peak deflection under a 1.0 kPa load by between 13 and 19% for lower and upper bound application of the rule of mixtures. However, module shape was captured, implying that a useful replication of a resolved model could be achieved with a reduced, calibrated material stiffness. Homogenized stress results captured glass layer tensile stress components to within 46 to 52% at a sample location of interest, though agreement was poor through the remainder of the laminate due to the lack of material resolution. For plate theory, deflection was overpredicted by 45 to 67% for upper and lower bound homogenizations, and frame-adjacent module shapes were not adequately replicated. Stress results mirrored FEM trends but magnitudes were not well correlated to resolved model values. These results support the use of homogenized laminate models for module shape derivation, though resolved models remain necessary for stress analyses. The accuracy of plate theory was found to be inadequate for most applications.
The dynamic connectedness between private equities and other high-demand financial assets: A portfolio hedging strategy during COVID-19
Authors: Papathanasiou Spyros , Vasiliou Dimitrios , Magoutas Anastasios , Koutsokostas Drosos 
Published: July 2023

In view of the need for portfolio diversification, we investigate the interlinkages between a private equity ETF and a set of high-demand asset classes including bonds, equities, crude oil, gold, commodities, currency, Bitcoin, and shipping within a spillover framework. For this objective, we apply the enhanced modification of the Diebold and Yilmaz approach for the period 1 January 2010 to 31 January 2023. The empirical findings indicate a modest degree of connectedness among the investigated markets, whereas volatility spillovers showed acceleration during tumultuous periods. In addition, we assess the capacity of private equities for hedging, for the whole sample period and during COVID-19 infectious disease, in order to suggest investors for potential portfolio restructures. Results demonstrate that the short position in the volatility of private equity ETF can result in strong hedging effectiveness for investors holding long positions in Bitcoin, shipping, bonds, and crude oil. JEL Classification: C32, C58, G11, G15
Ethical climate in healthcare: A systematic review and meta-analysis
Authors: Essex Ryan , Thompson Trevor , Evans Thomas Rhys , Fortune Vanessa , Kalocsányiová Erika , Miller Denise , Markowski Marianne , Elliott Helen 
Published: July 2023

Background Ethical climate refers to the shared perception of ethical norms and sets the scope for what is ethical and acceptable behaviour within teams. Aim This paper sought to explore perceptions of ethical climate amongst healthcare workers as measured by the Ethical Climate Questionnaire (ECQ), the Hospital Ethical Climate Survey (HECS) and the Ethics Environment Questionnaire (EEQ). Methods A systematic review and meta-analysis was utilised. PSYCINFO, CINAHL, WEB OF SCIENCE, MEDLINE and EMBASE were searched, and papers were included if they sampled healthcare workers and used the ECQ, HECS or EEQ. Ethical consideration Ethical approval was not required. Results The search returned 1020 results. After screening, 61 papers were included ( n = 43 HECS, n = 15 ECQ, n = 3 EEQ). The overall sample size was over 17,000. The pooled mean score for the HECS was 3.60. Mean scores of individual studies ranged from 2.97 to 4.5. For the HECS studies, meta-regression was carried out. No relationship was found between the country of the studies, the study setting (ICU v non-ICU settings) or the mean years of experience that the sample had. For the ECQ, sub-scales had mean scores ranging from 3.41 (instrumental) to 4.34 (law) and were all observed to have significant and substantial heterogeneity. Three studies utilised the EEQ so further analysis was not carried out. Conclusions The above results provide insight into the variability of scores as measured by the HECS, ECQ and EEQ. To some extent, this variability is not surprising with studies carried out across 21 countries and in a range of healthcare systems. Results also suggest that it may be that more local and context specific factors are more important when it comes to predicting ethical climate.
Revitalizing the Retail: A Case of the Coca-Cola Company
Authors: Khan Tauseef Iqbal , Raza Syed Ali 
Published: July 2023

In April 2017, a senior delegation of the Coca-Cola Company (TCCC) visited Pakistan to reconsider the beverage industry of the country predominated by its strong competitor PepsiCo. Followed by the visit, TCCC planned to revitalize its retail practices and join hands with retailers more aggressively. TCCC claims to be the world’s largest non-alcoholic beverage producer; however, lacking distribution intensity in the country. The company operates majorly in four trade channels based on volumetric divisions. The company began its operation in 1953 with a basic cola drink and later introduced its subsequent products in different flavours with two major categories sugar-contained and sugar-free. With an expansion of the industry and increased demand for bottled water and healthy conscious sugar-less nectar, the company expanded its product category and coverage to the deeper parts of the country. Because of substantial investment and legacy, Coca-Cola is the second-largest beverage company in a highly competitive soft drink market. However, TCCC is still lagging in leading, so the company decided to gear up all efforts in retail development followed by an intensive distribution strategy.
A Pilot Study on Testing Real Life Delivery Room Experience by Direct Observation and Supervised “Hands-on” Component in Imparting Neonatal Resuscitation Skill to Intern Doctor
Authors: Bhatt Shwetal M. , Parmar Priyanka , Patel Parvati 
Published: July 2023

Background Intern doctors are often incompetent to perform neonatal resuscitation, which is an essential skill and core competency area of pediatric curriculum. Methods We aimed to analyze the impact of direct observation and supervised “hands-on” component along with standard basic neonatal resuscitation training for intern doctors. An educational interventional study was conducted among interns after being approved by ethics committee. Mannequin based Basic neonatal resuscitation training of intern doctors was demonstrated. After that one week observership for real-life experience in NICU was given, where they observed minimum 5 delivery calls under the supervision of senior resident/faculty. Learning gain of the interns was analyzed by comparing the pre- and post-training test score. Knowledge based questions and objective structured clinical examination (OSCE) stations were used for the assessment. The OSCE was used to check the skills acquisition among intern doctors. Interns post workshop and post observership feedback in the form of reflection were analyzed. Faculty’s feedback in the form of reflection was analyzed. Results A total of 8 interns completed both pre and post training test for the level 2 evaluation-learning gain. Mean test scores of knowledge based questions and OSCE increased significantly from 85% to 97.5% and 33.33% to 100%, respectively. Pre- and post-workshop OSCE revealed 100% achievement of clinical skill of neonatal resuscitation. Intern doctors perceive that NRP training program improved their confidence levels and decreased the fear to perform neonatal resuscitation during first golden hour of life to save life of newborn. BNRP program is one of the core components to impart a clinical skill as an integral part of learning during internships. Conclusion Direct observation and supervised “hands-on” component as an additional teaching-learning method was well perceived and competency of interns for neonatal resuscitation was significantly enhanced. BNRCP competent IMG/intern being the first contact physician will be able to survive the newborn and contribute in decreasing neonatal mortality rate.
Development of a Communication Tool for Handoffs Involving Patients Cared for by Sitters: An Evidence-Based Practice Project
Authors: Hawley Paige , Holst Rachel , Bredlow Jennifer , Nichols Tara 
Published: July 2023

Problem Communication has been found to be central to patient safety and colleague engagement. Poor communication was identified in a Level III trauma hospital in the midwestern US between “sitters” (staff members assigned to monitor patients identified as having safety concerns) and the nurses assigned to care for those patients, including lack of a formal handoff process. Approach A Patient/Problem, Intervention, Comparison, Outcome (PICO) statement guided an evidence-based project and identification of an intervention to improve the handoff process. Using the evidence-based format of Situation/Background/Assessment/Recommendation (SBAR), a Patient Safety Attendant Handoff Form was developed and implemented. Results Initially, Registered Nurses (RNs), Licensed Practical Nurses (LPNs), or Certified Nursing Assistants (CNAs) were used as sitters, taking them away from other responsibilities. A formal position, Patient Safety Attendant (PSA), was created to perform the sitter role. The Patient Safety Attendant Handoff tool was made an official hospital form and implemented as a new standard of practice. Analysis of data from completed forms identified the top reasons for assigning a sitter were mental health and behavioral concerns. In a six-month post-implementation survey, most PSAs reported receiving adequate information about the patients during handoffs using the new form. Conclusion Using SBAR for the Patient Safety Attendant Handoff Form improved communication between RNs and PSAs and also enhanced communication between PSAs. A key safety feature of the form is the Recommendation section which includes “triggers to avoid,” de-escalation techniques, and things the patient enjoys. Developing a structural model from the aggregated data on the completed forms helped in analyzing the information.
Validation of Esaso Classification of Diabetic Maculopathy
Authors: Panozzo Giacomo , Franzolin Elia , Giannarelli Diana , Dalla Mura Giulia , Longo Rosa , Cicinelli Maria Vittoria , Angelini Edoardo , Airaghi Pietro , Avitabile Teresio , Bandello Francesco , Beccastrini Andrea , Benedetti Giorgia , Bertuzzi Federico , Bonfiglio Vincenza Maria Elena , Boscia Francesco , Carnevali Adriano , Carosielli Marianna , Cereda Matteo Giuseppe , Contardi Cecilia , Coppola Michele , Costagliola Ciro , Cristofolini Riccardo , Cucciniello Pasquale , D’Aloisio Rossella , De Bernardo Maddalena , De Filippis Alessandro , Dell’Omo Roberto , Di Paola Ilenia , Dell’Acqua Matteo , Franco Alessio , Grassi Maria Oliva , Gregori Giulia , Gusson Elena , Lattanzio Rosangela , Lanzetta Paolo , Longo Antonio , Marchini Giorgio , Marolo Paola , Mastropasqua Rodolfo , Bertoldo Giuliana Mele , Monteleone Giuseppina , Ortisi Elina , Parisi Guglielmo , Parrulli Salvatore , Pucci Porzia , Pastore Marco Rocco , Reibaldi Michele , Rizzo Stanislao , Romano Francesco , Rosa Nicola , Sarao Valentina , Scarpa Giuseppe , Scorcia Vincenzo , Scupola Andrea , Staurenghi Giovanni , Sunseri Trapani Valentina , Tognetto Daniele , Trabucchi Giuseppe , Vaccaro Sabrina , Vadalà Maria , Veritti Daniele , Vinciguerra Alex Lucia , Zanzottera Emma Clara 
Published: July 2023

Purpose To test reliability and reproducibility of ESASO morphologic OCT-based classification of diabetic maculopathy (DM). Methods This is a multi-center cross-sectional study including a coordination center (CC) and 18 participating centers (PCs). After instruction on the correct use of ESASO Classification, the validation process was carried out in two consecutive stages. In the first retrospective phase, we evaluated the concordance between PCs and CC in the staging of OCT images collected during PCs’ daily activity (608 images). In a second prospective phase, we analyzed the inter-observer agreement of staging assigned by each PCs to OCT images selected by the CC (22 images). Results The overall concordance achieved in the retrospective phase was 89.8% (Kappa = 0.83 (95% CI: 0.78–0.87); p<0.0001). In 99.5% of cases, concordance did not differ by more than one stage. In the prospective phase, PCs reached an inter-operator agreement of 93.0% (Krippendorff's Alpha = 0.953, 95% CI: 0.929–0.977, p<0.0001). Any discrepancy among the 22 images was within one stage. Conclusion The results achieved in this study confirm that ESASO OCT-based Classification can be considered as an easy and reproducible method to stage DM during clinical practice. A diffused use of a common and validated method to describe the progression of retinal damage in DM may offer several clinical and scientific advantages.
Incidental finding of an aortic aneurysm in a paediatric patient with tuberous sclerosis - A case report with literature review
Authors: Kong Kar Yee Catrin , Ting Chun Yi , Merchant Khurshid , Lai Angeline Hwei Meeng , Chowdhury Sudipta Roy 
Published: July 2023

Background: While common in the elderly population, abdominal aortic aneurysms (AAAs) are rare in the paediatric population and reported to be more common in patients with connective tissue disorders or certain genetic conditions such as tuberous sclerosis complex (TSC). Presenting symptoms of an AAA can be varied, and can range from being completely asymptomatic, to symptoms including a pulsatile abdominal mass, hypertension, back pain and even rupture. Aortic aneurysms in patients with TSC have been reported presenting at varying age groups. Case description: We report a case of TSC associated with an incidental finding of an abdominal aortic aneurysm in a child. Ultrasound of the abdomen revealed a renal aortic abdominal aneurysm. Computed tomographic angiogram and magnetic resonance imaging of the abdomen confirmed this finding with wall thinning over its right lateral aspect. The child underwent surgical repair of her abdominal aortic aneurysm and recovered uneventfully. Discussion: This case highlights the importance of monitoring patients with TS closely for signs and symptoms of aortic aneurysms and to proceed with screening scans for an early diagnosis. If left untreated, AAA carries a high-risk of morbidity and mortality in the event of a rupture.