bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic Status on Survival Outcomes in Patients with Colorectal Cancer: A Cross-sectional Study
Authors: Zhu Bin , Hu Fei-Hong , Jia Yi-Jie , Zhao Dan-Yan , Zhang Wan-Qing , Tang Wen , Hu Shi-Qi , Ge Meng-Wei , Du Wei , Shen Wang-Qin , Chen Hong-Lin 
Published: July 2023

Abstract
Background
Colorectal cancer (CRC) is widely acknowledged as a prevalent malignancy and the second most common cause of cancer-related mortality worldwide. The aim of this study was to examine the independent impact of Median Household Income (MHI) on prognosis and survival outcomes in patients with CRC.
Methods
Data from 17 cancer registries of the United States Surveillance, Epidemiology, and End Results program, with follow-up extended until November 2022 was analyzed. A Cox proportional hazards regression analysis was conducted to evaluate the influence of different levels of MHI on survival outcomes among patients with CRC. A total of 761,697 CRC patient records were retrieved from the SEER database.
Results
The Cox regression analysis results indicated that patients with higher MHI exhibited improved overall survival outcomes when compared to those with lower MHI (MMHI: HR = 0.925, 95% CI = 0.916–0.935, P < 0.001; HMHI: HR = 0.861, 95% CI = 0.851–0.870, P < 0.001). Regardless of the specific tumor location, gender, or treatment method, higher MHI is consistently linked to improved survival outcomes. However, this association was not found to be statistically significant among American Indian/Alaska Native (MMHI: P = 0.017; HMHI: P = 0.081), Asian or Pacific Islander (MMHI: P = 0.223; HMHI: P = 0.002) and unmarried or domestic partner patients (MMHI: P = 0.311; HMHI: P = 0.011).
Conclusion
These results emphasize the importance of considering socioeconomic factors, such as income level, in understanding and addressing disparities in survival outcomes of CRC patients.
Maternal Health Outcomes in the context of fragility: A Retrospective Study from Lebanon
Authors: Dimassi Hani , Alameddine Mohamad , Sabra Nadine , Arnaout Nour El , Harb Ranime , Hamadeh Randa , Kak Faysal El , Shanaa Abed , Mossi Marta Orozco , Saleh Shadi , AlArab Natally 
Published: July 2023

Abstract
Background and aims:
The Lebanese healthcare system faces multiple challenges including limited capacities, shortage of skilled professionals, and inadequate supplies, in addition to hosting a significant number of refugees. While subsidized services are available for pregnant women, representing the majority of the refugee population in Lebanon, suboptimal access to antenatal care (ANC) and increased maternal mortality rates are still observed, especially among socioeconomically disadvantaged populations. This study aimed to review the maternal health outcomes of disadvantaged Lebanese and refugee pregnant women seeking antenatal care services at primary healthcare centers (PHCs) in Lebanon.
Methods
A retrospective chart review was conducted at twenty PHCs in Lebanon, including Ministry of Public Health (MOPH) and United Nations Relief and Works Agency for Palestine refugees (UNRWA) facilities. Data was collected from medical charts of pregnant women who visited the centers between August 2018 and August 2020. Statistical analysis was performed to explore outcomes such as the number of ANC visits, delivery type, and onset of delivery, using bivariate and multivariable logistic regression models.
Results
In the study, 3977 medical charts were analyzed. A multivariate logistic regression analysis, revealed that suboptimal ANC visits were more common in the Beqaa region and among women with current abortion or C-section. Syrians had reduced odds of C-sections, and Beqaa, Mount Lebanon, and South Lebanon regions had reduced odds of abortion. Suboptimal ANC visits and history of C-section increased the odds of C-section and abortion in the current pregnancy. As for preterm onset, the study showed an increased likelihood for it to occur when being Palestinian, having current C-section delivery, experiencing previous preterm onset, and enduring complications at the time of delivery.
Conclusion
This study suggests the need for low-cost interventions aiming at enhancing access to ANC services, especially among pregnant women in fragile settings.
CGMega: Explainable Graph Neural Network Framework with Attention Mechanisms for Cancer Gene Module Dissection
Authors: Li Hao , Han Zebei , Sun Yu , Wang Fu , Hu Pengzhen , Ren Chao , Xu Xiang , Chen Hebing , Yang Yang , Bo Xiaochen 
Published: July 2023

Abstract
Cancer is rarely the straightforward consequence of an abnormality in a single gene, but rather reflects a complex interplay of many genes, represented as gene modules. Here, we leveraged the recent advances of model-agnostic interpretation approach and developed CGMega, an explainable and graph attention-based deep learning framework to perform cancer gene module dissection. CGMega outperforms current approaches in cancer gene prediction, and it provides a promising approach to integrate multi-omics information. We applied CGMega to breast cancer cell line and acute myeloid leukemia (AML) patients, and we uncovered the high-order gene module formed by ErbB family and tumor factors NRG1, PPM1A and DLG2. We identified 396 candidate AML genes, and observed the enrichment of either known AML genes or candidate AML genes in a single gene module. We also identified patient-specific AML genes and associated gene modules. Together, these results indicate that CGMega can be used to dissect cancer gene modules, and provide high-order mechanistic insights into cancer development and heterogeneity.
CTHRC1 promotes the progression of clear cell renal cell carcinoma via the PI3K/AKT/GSK3β signaling pathway
Authors: Xie Wei , Zhang Yuanfeng , Zhang Ronggui 
Published: July 2023

Abstract
CTHRC1 is a tumor-associated protein involved in the remodeling of solid tumor tissue and closely related to tumor development. The character of CTHRC1 in ccRCC is unknown.With the purpose of investigating its role in ccRCC, a variety of analytical methods were used in this study. RT-qPCR and WB experiments were used to measure CTHRC1 expression in ccRCC. CTHRC1 was knocked down in tumor cells using siRNA and verified by RT-qPCR and WB. The functions of CTHRC1 in ccRCC cells were studied by CCK8, EdU, Transwell, and wound healing assays. The results showed that the proliferation and metastasis capacity of ccRCC would be inhibited by knocking down CTHRC1. The effect of CTHRC1 on ccRCC was studied in vivo with a nude mouse tumor transplantation model. By a bioinformatics approach, we learned that CTHRC1 was abundantly expressed in ccRCC tissues and was closely related to the prognosis of ccRCC patients. The GSEA results showed that CTHRC1 may be associated with EMT, which is regulated by the pathway of PI3K/AKT/GSK3β in ccRCC. In conclusion, CTHRC1 may be a promising therapeutic target for ccRCC by mediating the PI3K/AKT/GSK3β pathway.
A Comprehensive Review of 5G Networks for Sustainable and Smart
Cities
Authors: Kumar Sunil , Vaid Varun , Thakur Garima 
Published: July 2023

Abstract:
The transition from the first generation of technology, which only had an analog voice, to
the fifth generation, which also had connected gadgets, gave the technology a new structure and
changed how people used it. Fifth-generation wireless technology, often known as 5G, is on the
cusp of reaching its potential maximum data transfer rate with a peak data throughput of 20 gigabits
per second (Gbps) and a typical data transfer rate of more than 100 megabits per second (Mbps).
The Internet of Things serves as the cornerstone of the future, and it is projected that by 2025, individual
users will use 13 times the amount of data that we do at this time. Therefore, 5G is extremely
important and the main feature of the 2030 Sustainable Development Agenda, which was ratified by
all of the Member States of the United Nations in 2015, and is the 17 Sustainable Development
Goals (SDGs), which represent an urgent call to action for all nations. These goals are referred to
collectively as the "SDGs." This study intends to examine how 5G networks might serve as important
facilitators for achieving sustainability and meeting some of the 17 SDGs. This is further
highlighted by evaluating the sustainability metrics for 5G networks. Ultimately, this helps to
demonstrate that 5G networks are environmentally, socially, and economically responsible. This
study focuses on the five primary SDGs that are important for the growth of smart cities.
User Retention and Engagement in the Digital-Based Diabetes Education and Self-Management for Ongoing and Newly Diagnosed (myDESMOND) Program: Descriptive Longitudinal Study
Authors: Barker Mary M , Chauhan Radhika , Davies Melanie J , Brough Christopher , Northern Alison , Stribling Bernie , Schreder Sally , Khunti Kamlesh , Hadjiconstantinou Michelle 
Published: July 2023

Background
Digital health interventions have the potential to improve the physical and psychosocial health of people living with type 2 diabetes. However, research investigating the long-term (≥1 year) retention and engagement of users within these programs is limited.

Objective
The aim of this study was to evaluate long-term user retention and engagement in the digital-based Diabetes Education and Self-Management for Ongoing and Newly Diagnosed (myDESMOND) program, using real-world data.

Methods
Anonymized data from all myDESMOND users who registered with the program on or before November 16, 2020, were included in the analyses. User retention was defined as the period between the day a user registered with the myDESMOND program and their last day of access. The primary engagement outcome was defined as the total number of log-ins to the program per user. The associations between retention, engagement, and sociodemographic factors (age, sex, and ethnicity) were tested using Cox regression models and Wilcoxon rank sum tests.

Results
A total of 9522 myDESMOND users were included in this analysis. Of the 9522 users, 5360 (56.29%) remained on the program for at least a month, whereas 1676 (17.6%) remained on the program for at least 1 year. Retention was significantly higher among older users; the adjusted hazard ratio (representing the risk of users leaving the program within the first year) among users aged ≥50 years, compared with those aged <50 years, was 0.79 (95% CI 0.75-0.84; P<.001). The median number of myDESMOND log-ins per user was 8 (IQR 4-8); however, this was significantly lower among users aged <50 years (P<.001). Engagement metrics also differed according to sociodemographic characteristics; the estimated time spent per log-in was 5.35 (IQR 2.22-11.80) minutes among all users; however, this was significantly higher among female users (P<.001), users aged ≥50 years (P<.001), and users of White ethnicity (P=.02).

Conclusions
Although retention and engagement of users within myDESMOND were found to be high, these findings highlight the need for age- and culture-specific implementation strategies and content adaptations to improve retention and engagement among all users of self-management programs.
TAX BURDEN AS AN INDICATOR OF THE EFFICIENCY OF THE TAX SYSTEM IN UKRAINE
Authors: Gavrylenko V. O. , Demydenko S. L. 
Published: July 2023

The article defines the essence of taxes as the main source of the revenue part of the country's budget. The meaning and purpose of the tax burden are revealed. It is proved that the efficiency of the tax system depends on the structure of tax revenues and the overall level of the tax load on the economy. The structure of tax revenues and other revenue items of the consolidated budget of Ukraine for 2017-2022 is analyzed. The results of the analysis show that tax revenues and their share in revenues decreased in 2022, correspondingly there were changes in the specific weight of individual taxes and fees.
The assessment of the tax burden in Ukraine in various ways shows a significant difference between the values of the general level of the tax burden and the level without taking into account the single social contribution. It is determined that, in addition to national and local taxes and fees, the receipt of a single contribution to mandatory state social insurance has a significant impact on the overall level of the tax burden.
The results of a comparison of the tax burden in Ukraine and the countries of the European Union show that in our country its value is at a low level. It is proven that the differences between countries with a high and low level of tax burden are determined by the economic policy of each country regarding public expenditures and tax structures.
In order to assess the efficiency of the tax system of Ukraine, a comparative analysis of indicators of the ease of paying taxes with similar indicators of EU countries has been carried out. The results of the analysis show that the tax system in Ukraine is quite complex, in particular, in terms of preparing and submitting tax returns, which makes doing business difficult.
The main priorities for ensuring the optimal level of the tax burden in Ukraine, such as: increase of the efficiency of tax administration, neutralization of negative impact on doing business, study of the European experience of transforming tax systems, have been determined.
THE ABILITY OF HIGHER EDUCATION SYSTEM OF UKRAINE TO PROVIDE PERSONNEL NEEDS OF THE NATIONAL RENEWABLE ENERGY INDUSTRY
Authors: Zakharova O.V. 
Published: July 2023

The study made it possible to establish that the current state of training specialists in the field of renewable energy will not allow in the near future to quickly achieve the goals of intensive development of renewable energy proclaimed by the country's leadership. This will not improve the energy security of the regions and the country as a whole. This conclusion is based on the fact that, firstly, the training of specialists in Ukraine in educational programs on renewable energy is carried out by a limited number of higher education institutions, a significant number of which are accredited only by mid-2024. Secondly, the number of applicants operating in the current educational mastered this specialty in all years of study is not high. This will make it possible to rejuvenate the staff of workers serving existing renewable energy facilities. However, it will not allow to achieve the rapid development of projects for the introduction and use of alternative energy sources in the country. The work systematizes the markers of success, the focus on which by the guarantors of educational programs on renewable energy will improve the quality of educational services and interest applicants. These markers define the highly professional staff of teachers in the framework of educational programs; provision of the educational process of the educational program with certified laboratories with high-tech equipment; the availability of double degree programs in the specialty of the world's leading universities and international mobility programs; conducting joint scientific research with foreign scientists; introduction of a practice-oriented approach to learning.
The most effective directions for increasing the number of highly qualified profile specialists in renewable energy in the labor market of Ukraine in the post-war period are formulated. These areas were recognized as increasing the level of wages in the field of renewable energy; ensuring a high level of investment for the development of human capital in renewable energy enterprises; expanding opportunities for professional development in the industry; improving the quality of existing and opening new educational programs for training specialists in renewable energy; providing a full cycle of training specialized professionals on the basis of the country's leading institutions; increase in public opinion the prestige of the entire spectrum of professions related to renewable energy. This should allow solving the rather painful problem of energy security for Ukraine.
PRETRATAMIENTO CON CAMPO MAGNÉTICO EN LA FERMENTACIÓN DE EMULSIONES DE CARNE DE CERDO
Authors: Gelvez Ordoñez Víctor Manuel , Rolón Moreno Ana Milena , Caballero Pérez Luz Alba 
Published: July 2023

La demanda de alimentos inocuos, mínimamente procesados y saludables por parte de los consumidores ha generado la necesidad de desarrollar nuevas tecnologías para cubrir dichas necesidades, estas deben ser sostenibles con el medio ambiente, por lo tanto, el objetivo de este trabajo fue evaluar el efecto del pretratamiento con Campo Magnético Estático- CME en la fermentación de emulsiones de carne de cerdo. Se preparó una emulsión %P/P con 15,03% proteína, 24,64% grasa, 57,64% agua, 1,90% sal, 0,02% nitrito, 0,1% cultivo y 0,67% lactosa. Se sometió a tratamiento con CME de 4,5mT durante 0, 3, 5 y 10 minutos. Posteriormente las muestras

fueron almacenadas durante 20 días a temperatura ambiente. Se evaluó el pH, color, estabilidad y humedad durante los días 1, 4, 8, 12, 16 y 20 y la microbiota se analizó el día 1 y 20. Se encontró que la emulsión es estable y su humedad no varía. El pH no varía con el pretratamiento, pero sí disminuye con el tiempo de almacenamiento. La actividad microbiana de Lactobacillus bulgaricus se ve afectada por el pretratamiento, pero exhibe una recuperación a los 4 días de almacenamiento. La luminosidad disminuye con el pretratamiento este efecto se mantiene hasta el día 4. En el parámetro a* del color el pretratamiento causa aumento en la escala, este cambio resulta proporcional al tiempo de tratamiento. El parámetro b* presenta disminución hasta el día 8 y posteriormente exhibe el comportamiento contrario. Estos cambios están relacionados con el tiempo del tratamiento. Se presentan reducciones de los coliformes totales a 200UFC/g y coliformes fecales a <3UFC/g en las muestras, por efecto de las condiciones de almacenamiento.
TIPOLOGI PAHAM KEAGAMAAN MAHASISWA FAKULTAS ILMU KEOLAHRAGAAN UNIVERSITAS NEGERI MAKASSAR
Authors: Amri Rahman  
Published: July 2023

Penelitian ini bertujuan untuk mengetahui tipologi pemahaman keagamaan mahasiswa FIK UNM melalui model kajian keagamaan yang diikuti mahasiswa FIK UNM dan pandangan mereka terhadap isu-isu keagamaan. Jenis penelitian yang digunakan pada penelitian ini yakni penelitian kualitatif dengan menggunakan pendekatan deskriptif. Penelitian ini menggunakan teknik purposive random sampling, yaitu teknik penentuan sampel dengan pertimbangan tertentu, selanjutnya dirandom, maka yang menjadi sampel dalam penelitian ini adalah mahasiswa aktif maupun tidak aktif dalam kelompok kajian keagamaan di Fakultas Ilmu Keolahragaan. Adapun teknik pengumpulan data yang dilakukan dalam penelitian ini adalah observasi, wawancara dan dokumentasi dengan teknik analisis data yang digunakan adalah teknik analisis data kualitatif deskriptif. Hasil penelitian menunjukkan bahwa tipologi pemahaman keagamaan mahasiswa FIK UNM secara umum dapat diklasifikasi ke dalam 3 (tiga) tipe, yaitu inklusif, ekslusif dan moderat, tetapi pada umumnya mahasiswa memiliki pemahaman keagamaan yang bersifat moderat. Sikap moderasi tersebut tampak dari model kajian keagamaan yang diikuti oleh mahasiswa yaitu arriyadhoh yang memiliki model kajian yang bersifat moderat. Moderasi beragama mahasiswa FIK UNM tampak juga dari pandangan mereka terhadap isu-isu keagamaan yang diperdebatkan oleh ulama. Mahasiswa FIK UNM welcome terhadap perbedaan pendapat, sehingga mereka tidak memiliki sikap fanatisme terhadap satu pendapat dan tidak pula menyalahkan pendapat yang lain.
An Installation Angle Error Calibration Method in an Ultra-Short Baseline System Based on a Dual Transponder
Authors: Liu Baoheng , Zhang Xiaochuan , Jia Shuyang , Zou Sichen , Tian Deyan , Da Lianglong 
Published: July 2023

Abstract
The installation error of an acoustic transceiver array is one of the important error sources in an ultra-short baseline (USBL) system. In a USBL system with a positioning accuracy of 0.5%, an installation error angle of 1° will lead to a positioning error of 1.7% times the slant distance. In this paper, a dual transponder-based installation angle error calibration method for USBL is proposed. First, the positioning errors induced by various installation angles are deduced and analysed using the linear measurement of seafloor targets. Then, an iterative algorithm is proposed that estimates the rolling alignment error, pitching alignment error, and heading alignment error, in that order. The simulation and experienced results show that, after three iterations, the estimates of the three alignment errors can converge quickly, all of the estimates converge to within 0.001° and the estimated values are very close to the true values. The horizontal positioning error caused by the installation error angle can be reduced by nearly 75%. The method has good effectiveness and robustness, and can greatly improve the positioning accuracy of the USBL system.
Comments on Existing Analytical Solutions to the Wave-Induced Cyclic Response of a Porous Seabed of Infinite Thickness
Authors: Magda Waldemar 
Published: July 2023

Abstract
This paper deals with the wave-induced cyclic response of a porous seabed (by means of oscillating parameters: pore-fluid pressure, soil displacement components, effective normal stress and shear stress components) due to a surface sinusoidal water-wave propagating over a seabed of infinite thickness. The main existing analytical solutions to the governing problem are critically discussed, pointing out their meaningful errors and doubtful items. A phase-lag phenomena is particularly studied as an immanent part of any complex-valued analytical solutions having a cyclic nature.