bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Fuzzy Deep Neural Networks for Covid 19 diagnosis through chest Radiographs
Authors: Yadlapalli Priyanka , D Bhavana 
Published: January 2023

Background: The increasing number of COVID-19 patients around the world and the limited number of detection kits pose a challenge in determining the presence of the disease. Imaging modalities such as X-rays are commonly used because they are readily available and cost-effective. Deep learning has proved to be an excellent tool because of the abundance of online medical images in various medical modalities, such as X-Ray, computerized tomography (CT) Scan, and magnetic resonance imaging (MRI). A large number of medical research projects have been proposed and launched since early 2020 due to the overwhelming use of deep learning techniques in medical imaging. Methods: We have used fuzzy logic and deep learning to determine if chest X-ray images belong to people who have pneumonia related to COVID-19 and people who have interstitial pneumonias that aren't related to COVID-19. Results: In comparison to the current literature, the proposed transfer learning approach is more successful. It is possible to classify covid, viral, and bacterial pneumonia or a healthy patient using ResNet 18 Architecture's four-class classifiers. The proposed method achieved a 97% classification accuracy, 96% precision, and 98% recall in the case of COVID-19 detection using chest X-ray images, which demonstrates the importance of deep learning in medical image diagnosis. Furthermore, the results demonstrate that the proposed technique has the maximum sensitivity rate, with 97.1% ratio. Finally, with a 97.47% F1-score rate, the proposed strategy yields the highest value when compared to the others. Conclusions: DeepLearning techniques and fuzzy features resulted in an improved classification ability, with an accuracy rate of up to 97.7% using ResNet 18, which is a better value when compared to the remaining techniques. Classification of COVID-19 scans and other pneumonia cases have been done successfully by demonstrating the potential for applying such deep learning techniques in the near future.
Identification of the SIRT1 gene's most harmful non-synonymous SNPs and their effects on functional and structural features-an in silico analysis
Authors: Thayyil Menambath Desy , Adiga Usha , Rai Tirthal , Adiga Sachidananda , Shetty Vijith 
Published: January 2023

Introduction: The sirtuin (Silent mating type information regulation 2 homolog)1(SIRT1) protein plays a vital role in many disorders such as diabetes, cancer, obesity, inflammation, and neurodegenerative and cardiovascular diseases. The objective of this in silico analysis of SIRT1's functional single nucleotide polymorphisms (SNPs) was to gain valuable insight into the harmful effects of non-synonymous SNPs (nsSNPs) on the protein. The objective of the study was to use bioinformatics methods to investigate the genetic variations and modifications that may have an impact on the SIRT1 gene's expression and function. Methods: nsSNPs of SIRT1 protein were collected from the dbSNP site, from its three (3) different protein accession IDs. These were then fed to various bioinformatic tools such as SIFT, Provean, and I- Mutant to find the most deleterious ones. Functional and structural effects were examined using the HOPE server and I-Tasser. Gene interactions were predicted by STRING software. The SIFT, Provean, and I-Mutant tools detected the most deleterious three nsSNPs (rs769519031, rs778184510, and rs199983221). Results: Out of 252 nsSNPs, SIFT analysis showed that 94 were deleterious, Provean listed 76 dangerous, and I-Mutant found 66 nsSNPs resulting in lowered stability of proteins. HOPE modelling of rs199983221 and rs769519031 suggested reduced hydrophobicity due to Ile 4Thr and Ile223Ser resulting in decreased hydrophobic interactions. In contrast, on modelling rs778184510, the mutant protein had a higher hydrophobicity than the wild type. Conclusions: Our study reports that three nsSNPs (D357A, I223S, I4T) are the most damaging mutations of the SIRT1 gene. Mutations may result in altered protein structure and functions. Such altered protein may be the basis for various disorders. Our findings may be a crucial guide in establishing the pathogenesis of various disorders.
Polymorphism studies and candidate genes associated with litter size traits in Indonesian goats. a systematic review
Authors: Abuzahra Mutasem , Abu Eid Loay , Effendi Mustofa Helmi , Mustofa Imam , Lamid Mirni , Rehman Saifur 
Published: January 2023

Background: Litter size (LS) is a significant, challenging, and economical aspect of the goat industry in Indonesia. It is influenced by several different factors and genes; consequently, identifying potential genes and loci associated with litter size has become a genetic problem. Several genetic indicators have been found to be associated with litter size in goats. This has prompted the need to discuss candidate genes associated with litter size in goats in Indonesia.Methods: A systematic review was conducted using critical databases including ResearchGate, Google Scholar, PubMed, Google search engine and Science direct. There were any exclusion criteria, they were as follows: articles published in languages other than English, Conference papers, short communication papers and papers not related to animals. After reviewing the abstracts of 42 publications, the remaining 17 investigations were chosen for full paper evaluation. A further eight studies were removed after a comprehensive evaluation of the publications because they did not match our inclusion criteria.Results: These markers include growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), bone morphogenetic protein receptor type IB (BMPR1B), and kisspeptin (KISS1). Single nucleotide polymorphisms in these genes contribute to the development of novel genetic markers that helps in the selection of goats with the most favorable genotypes for litter size. This type of genetic selection is more successful than the traditional way of selecting animals for reproductive traits, particularly litter size.Conclusions: As a result, this study summarizes the genetic impacts of polymorphisms in candidate genes associated with litter size features in Indonesian goats.
Chronic kidney disease to osteoporosis: histopathological analysis on animal model with unilateral ureteral obstruction method
Authors: Ermawan Rieva , Soetrisno Soetrisno , Purwanto Bambang , Wasita Brian , Helmi Zairin Noor 
Published: January 2023

Background: One of the most frequent complications due to the progression of chronic kidney disease (CKD) is the occurrence of disturbances in mineral metabolism.. Increased bone remodeling results in osteopenia, which can progressively lead to osteoporosis. Wistar albino rats (Rattus norvegicus) are one of the most well-known and easy-to-obtain laboratory test animals. Data regarding the duration of bone pathological progression in CKD-induced Wistar strain rats by the unilateral ureteral obstruction method are limited. Methods: This was a descriptive observational study, with a prospective cohort approach. The aim was to determine the histopathological onset of osteoporosis in Wistar rats with the CKD model. We used 13 male Wistar rats (Rattus norvegicus). The CKD rat models were randomized and put into four containers, each containing three rats. Each group was treated in the same way for predetermined durations, which were the 7th day, 14th day, 21st day, and 28th day after CKD modeling, before being sacrificed for femoral bone histopathological collection. Results: On the 7th day after CKD modeling, we discovered thickening of the periosteal fibrous tissue. On the 14th and 21st days, there was an increase in the thickness of the periosteal fibrous tissue in the metaphyseal and diaphyseal areas. This thickening progression was in line with the length of treatment time. On the 21st day, we began to see the increasing gap between the trabecular tissues. On the 28th day, the histopathological analysis of femoral bone tissue showed thinning of the bone trabecular tissue and the most distant inter-trabecular spaces, suggesting the appearance of osteoporosis. Conclusion: The histopathological picture of osteoporosis in the Wistar strain rat model of CKD appeared most clearly and worst on the 28th day after CKD. It was marked by the thinning of the trabecular bone tissue and the most distant spaces between the trabeculae.
Suicide and attempted suicide by insulin: A systematic review
Authors: Assad Majd A. , Alawami Fatimah A. , Al Khatem Raihanah S. , Al Daif Zahra Y. , Alrumaih Zainb A. , Menezes Ritesh G. 
Published: January 2023

Background: Intentional insulin overdose either in people with diabetes or without can be used to attempt suicide. Massive insulin administration may result in coma and unexplained hypoglycemia. In this study, we aim at reviewing the demographic data of suicidal cases, the relation of psychiatric illness to dying by suicide and attempting suicide using insulin, route of insulin administration and outcome, post-mortem findings in suicide by insulin and collaborative evidence, initial presentation, blood glucose level and complications in attempting suicide cases. Methods: PubMed, Web of Science, and Scopus databases were searched on October 4, 2021, using a comprehensive strategy review. The following search terms were applied: (Insulin) AND (toxicity OR overdose OR toxicology OR poisoning OR intoxication) AND (Suicide OR attempted suicide OR Self-harm OR Self harm). The search strategy was set based on PRISMA guideline; 11 papers were eligible for inclusion and additional 23 studies were added from the citation search. All English articles related to suicide and attempted suicide using insulin were included and no specific timeline or filter was used. Any non-English article and accidental or homicidal cases were excluded from the review. Results: The analysis included 179 victims, aged between 13 to 76 years with male predominance and people with diabetes, especially T1DM, having higher prevalence, with subcutaneous injection being the most common route of administration. In addition, psychiatric illnesses and multiple suicide attempts were identified in many cases besides the use of insulin in a combination with other medications. Conclusions: Dying by suicide using insulin is uncommon, however, as diabetes mellitus prevalence increases worldwide, it is expected that intentional insulin overdose will also increase. Furthermore, psychiatric illnesses and easy access to insulin are important factors that should be put into consideration.
Pre-service primary educators´ alternative conceptions of COVID-19 and post-COVID-19: a study of Universidad Técnica del Norte, Ecuador
Authors: Guerra-Reyes Frank , Naranjo-Toro Miguel , Basantes-Andrade Andrea , Guerra-Dávila Eric 
Published: January 2023

Background: Almost at the end of 2022, the world is experiencing a relative calm after the rigors imposed by the COVID-19 pandemic. Knowing the ideas, feelings and procedures used by people in this type of unexpected events, which exceeded all established standards of educational and health actions, can help us be prepared for the possible occurrence of similar events. This study aims to determine the main alternative conceptions that pre-service teachers hold about the pandemic and the post-pandemic within the framework of the four basic pillars of Education. Methods: A case study was conducted using an ethnographic approach. The unit of analysis was made up of 227 students from the major of Primary Education at Universidad Técnica del Norte. Two research instruments were used to collect the data: a test for verbal associations where participants can express themselves freely with hierarchical, substitution and connotative evocations; and Specialized Analytical Summary sheets to revise and organize specialized scientific texts. The data was analyzed using the IRaMuTeQ software. Results: At first glance, what was expressed in the two contexts, both in the pandemic and in the post-pandemic, show a similar structure; however, a deeper analysis reveals different perspectives. Conclusions: In the end, the alternative conceptions moved from expressing fear to tranquility.
Acuity-Based Allocation of ICU-Downstream Beds with Flexible Staffing
Authors: Valeva Silviya , Pang Guodong , Schaefer Andrew J. , Clermont Gilles 
Published: January 2023

Intensive care units (ICUs) are crucial resources within hospitals, caring for the most critically ill patients. We propose a novel modeling framework that improves the outflow of ICU patients by anticipating unit interactions and resource sharing within the system. Across an arbitrary bipartite network of units, we consider two types of downstream staffing (baseline and flexible) and a two-stage decision process. In the first stage, we determine the level of flexible bed staffing using existing physical beds at downstream units in anticipation of incoming transfers from the ICUs. In the second stage, we determine the allocation of ICU patients to downstream beds. The goal of the model is to reduce inefficiencies and transfer delays causing ICU bed block due to lack of space in downstream units. We formulate a dynamic multiperiod model and analyze the dual of its (relaxed) stationary counterpart. Decomposing the relaxed stationary model into an ICU and downstream subproblems, we calculate the relative values of downstream beds and derive a practical acuity-based policy for the daily operational decisions. Using a large-scale simulation calibrated with historic hospital data, we demonstrate that our acuity-based policy reduces the number of long-run diverted ICU arrivals, particularly in high-demand scenarios, thus improving ICU throughput, when compared with a deterministic, a generalized randomized-most-idle, and static policies. History: Accepted by J. Paul Brooks, Area Editor for Applications in Biology, Medicine, & Healthcare. Funding: This work was partially supported by National Science Foundation [Grants CMMI-1635301/1635410/1635642]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1267 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0133 ) at ( http://dx.doi.org/10.5281/zenodo.7194693 ).
Jiwa Jawi Content Management on Instagram @jiwajawijogja 2021
Authors: Fidela Almira Rahma , Sudiwijaya Erwan , Aulia Aly 
Published: January 2023

Purpose. The food (culinary) industry is currently one of the fatest- growing businesses. The Indonesian culinary tourism is not only in terms of the menu but also the art, culture, and philosophical values that make up the dish. The culinary business's development is increasing daily in Yogyakarta, and culinary tourism continues to grow every year. Culinary promotion patterns have also penetrated social media, one of which is @jiwajawijogja, which opened a new branch in Pogung with the name Jiwa Jawi Jogja.The methodology in this research is descriptive qualitative with data obtained from interviews with owner and content designer from @jiwajawijogja, observations on the official Instagram @jiwajawijogja, and documentation from news in online media.A finding of this study is the process of creating content at @jiwajawijogja has received a positive response through events that aim to bring the brand closer to its followers.Suggestion from this research to ensure the message is conveyed properly, we suggest that @jiwajawijogja focus on its targets audience and create hashtags according to the target audience.
From Bourbon Reform to Open Markets in California, 1801-1821
Authors: Duggan Marie Christine 
Published: January 2023

The Consulado de México was the mercantile guild that acted as commercial nerve-center of Spain’s empire in the Americas. From 1801 to 1821, one of its members, Pedro González de Noriega, influenced California’s economic growth by putting his nephew, José de la Guerra y Noriega, into the colony’s military supply line. In 1801, for what purpose did De la Guerra y Noriega come to California? Whatever his intention, his life-plan changed in 1810, when insurgency broke out in New Spain, and military payroll ceased to arrive in California. Between 1811 and 1821, how did De la Guerra y Noriega adapt to this structural change by negotiating with international merchants from Manila to San Blas and Lima to supply California? As Spain’s empire unraveled, we follow the microhistory of the Noriega mercantile network, as it reconfigured to the macroeconomic context of political transformation of the Pacific Rim in the context of Mexican independence from Spain. The De la Guerra Collection at the Santa Bárbara Mission Archive-Library reveals that Guadalajara was Mexico’s emerging center for Pacific commerce, with San Blas as Guadalajara’s principal port. By Mexican independence in 1821, De la Guerra had established Santa Bárbara, California as the center of his family’s business, rather than Mexico City. Even as Manila merchants relocated to Tepic, he maintained ties with them. He also traded with the British in Callao, Peru, which is how he came to send his son to be educated in Liverpool with the Brotherston family.
Prevalence of hypoglycemic conditions in adolescents with type 1 diabetes mellitus in real clinical practice
Authors: Tsargasova I. M. , Bashnina E. B. , Vorokhobina N. V. , Dubinina T. A. , Dosovitskaya E. R. , Platonov V. V. 
Published: January 2023

BACKGROUND. Hypoglycemia and fear of hypoglycemia remain critical problems in the treatment of adolescents with type 1 diabetes mellitus (DM1) and are factors limiting proper control of glycemia and preventing the achievement of metabolic compensation of the disease. The use of pump insulin therapy involves the prevention of hypoglycemic conditions.AIM. To analyze the frequency and duration of hypoglycemia episodes, their effect on the metabolic compensation of the disease in adolescents with type 1 diabetes mellitus (DM1) in real clinical practice, depending on the mode/method of insulin administration.MATERIALS AND METHODS. The study involved 117 adolescents with DM1 aged 12 to 19 years (average age 15.5 years). 37 adolescents received therapy by continuous subcutaneous insulin infusion (CSII); 80 adolescents received therapy by multiple insulin injections (MII). The level of glycated hemoglobin (HbA1c) was determined for all adolescents, and its main indicators were evaluated using a 6 days continuous glucose monitoring (CGM) by the «blind» method of a professional system with an iPro 2 sensor (Medtronic MiniMed, USA).RESULTS. Episodes of a decrease in glucose levels <3,9 mmol/l were recorded in 87% of patients (n=102), 63% (n=74) showed a decrease in glucose levels <3,0 mmol/l. Episodes decrease in glucose levels <3,9 mmol/l at night were recorded in 68% of patients (n=80), and with glucose levels <3,9 mmol/l in 46% (n=54). The frequency of episodes of glucose lowering <3,9 mmol/l had no statistically significant differences depending on the methods of insulin administration (by continuous subcutaneous insulin infusion or multiple insulin injections), however, they are more common in adolescents with HbA1c <7,0% (p=0,03). The median time spent by patients in the range of <3,9 mmol/l was 5% per day, and a longer time in this range was observed in patients with HbA1c <7,0% (p=0,006). The median time in the range of <3,0 mmol/l was 1% per day and had no significant differences depending on the level of HbA1c (p=0,559). There were also no significant differences depending on the groups using CSII and MII (p=0,640 and p=0,250).CONCLUSION. Episodes of glucose reduction in the range of <3,9 mmol/l according to CGM data are more common in adolescents with HbA1c target values, regardless of the method of insulin administration. Significantly more time in range of <3,9 mmol/l is spent by adolescents with target values of HbA1c i.е. <7,0% compared with HbA1c ≥7,0%, however, in both groups, a large number of patients had time in the range below the target level was higher than recommended values.
Peran Dukungan Sosial Keluarga dan Kemandirian Belajar terhadap Flourishing pada Mahasiswa yang Terancam Drop Out
Authors: Ridha A. Ahmad 
Published: January 2023

Flourishing is the highest level of human psychological well-being. Flourish conditions are needed by students who nearly drop out in completing their education at college. This study aims to determine the role of family social support in the flourishing of students who nearly drop out, moderated by independent learning. This study uses a quantitative approach at university X in Tarakan, North Kalimantan. The subjects of this study were 70 students who nearly dropped out. The results of the moderated regression analysis show that family social support and independent learning play a positive role in student flourishing. However, learning independence still needs to be proven to strengthen the role of family social support for flourishing students who nearly drop out. This means that independent learning does not have a significant moderating effect as a moderating variable. Flourishing merupakan tingkatan tertinggi dari kesejahteraan psikologis manusia. Kondisi flourish sangat dibutuhkan mahasiswa yang terancam drop out dalam menyelesaikan pendidikannya di institusi pendidikan. Penelitian ini bertujuan untuk mengetahui peranan dukungan sosial keluarga terhadap flourishing mahasiswa yang terancam drop out yang dimoderatori oleh kemandirian belajar. Penelitian ini menggunakan pendekatan kuantitatif di Universitas X di kota Tarakan, Kalimantan utara. Subjek penelitian ini adalah 70 orang mahasiswa yang terancam drop out. Hasil moderated regression analysis menunjukkan bahwa dukungan sosial keluarga dan kemandirian belajar secara bersama-sama berperan positif terhadap flourishing mahasiswa, namun kemandirian belajar tidak terbukti memperkuat peranan dukungan sosial keluarga terhadap flourishing mahasiswa yang terancam drop out. Ini berarti bahwa kemandirian belajar tidak memiliki efek moderator yang signifikan sebagai variabel moderator
Irrationality of Digital Medicine: VR, IoT and AI in Practice
Authors: Henry Shimo Shimo , Bondareva Inna 
Published: January 2023

Artificial Intelligence (AI) has potential to change the tasks that are currently being done by Human being. The Internet of Things (IoT) has potential to increase Medical Device connectivity, enabling more immediate information sharing and coordination between doctors and patients. Virtual reality (VR) has potential to enhance medical training. Digital Health technologies have the power to expand coverage of healthcare (access), enhance services (quality) and reduce/optimize resources (cost). Affordability, infrastructure, and human capability limits overall impacts of Digital Health technologies and must be addressed. Therefore, capacity building through strategic alliances and partnerships remains crucial in harnessing the promises of Digital Health Technologies. This paper summaries challenges in the implementation of Digital health Solutions among African health systems and enumerate the possible ways of addressing the identified challenges.
Keywords— Artificial Intelligence (AI), Internet of Things (IoT), Virtual Reality (VR) Digital Health, Remote Patient Monitoring RPM), Robotic Process Automation (RPA)
Classification of full exceptional collections on smooth toric Fano varieties with Picard rank two
Authors: Lee Dae-Won 
Published: January 2023

Abstract
In this paper, we give a complete classification of full exceptional collections, up to cyclic permutations, normalizations and mutations, on smooth toric Fano threefolds and fourfolds with Picard rank two. For such varieties, we find all the exceptional collections of maximal length and show that they are in fact full. This gives a partial answer to a conjecture in [29] and [32]. Moreover, such full exceptional collections essentially arise from Orlov’s theorem on projective bundles.