bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning tuning by diversity oriented firefly metaheuristics for Industry 4.0
Authors: Jovanovic Luka , Bacanin Nebojsa , Zivkovic Miodrag , Antonijevic Milos , Jovanovic Bojan , Sretenovic Marija Bogicevic , Strumberger Ivana 
Published: March 2023

AbstractThe progress of Industrial Revolution 4.0 has been supported by recent advances in several domains, and one of the main contributors is the Internet of Things. Smart factories and healthcare have both benefited in terms of leveraged quality of service and productivity rate. However, there is always a trade‐off and some of the largest concerns include security, intrusion, and failure detection, due to high dependence on the Internet of Things devices. To overcome these and other challenges, artificial intelligence, especially machine learning algorithms, are employed for fault prediction, intrusion detection, computer‐aided diagnostics, and so forth. However, efficiency of machine learning models heavily depend on feature selection, predetermined values of hyper‐parameters and training to deliver a desired result. This paper proposes a swarm intelligence‐based approach to tune the machine learning models. A novel version of the firefly algorithm, that overcomes known deficiencies of original method by employing diversification‐based mechanism, has been proposed and applied to both feature selection and hyper‐parameter optimization of two machine learning models—XGBoost and extreme learning machine. The proposed approach has been tested on four real‐world Industry 4.0 data sets, namely distributed transformer monitoring, elderly fall prediction, BoT‐IoT, and UNSW‐NB 15. Achieved results have been compared to the results of eight other cutting‐edge metaheuristics, that have been implemented and tested under the same conditions. The experimental outcomes strongly indicate that the proposed approach significantly outperformed all other competitor metaheuristics in terms of convergence speed and results' quality measured with standard metrics—accuracy, precision, recall, and f1‐score.
Decoding the crosstalk between mevalonate metabolism and T cell function
Authors: Kennewick Kelly T. , Bensinger Steven J. 
Published: March 2023

SummaryThe mevalonate pathway is an essential metabolic pathway in T cells regulating development, proliferation, survival, differentiation, and effector functions. The mevalonate pathway is a complex, branched pathway composed of many enzymes that ultimately generate cholesterol and nonsterol isoprenoids. T cells must tightly control metabolic flux through the branches of the mevalonate pathway to ensure sufficient isoprenoids and cholesterol are available to meet cellular demands. Unbalanced metabolite flux through the sterol or the nonsterol isoprenoid branch is metabolically inefficient and can have deleterious consequences for T cell fate and function. Accordingly, there is tight regulatory control over metabolic flux through the branches of this essential lipid synthetic pathway. In this review we provide an overview of how the branches of the mevalonate pathway are regulated in T cells and discuss our current understanding of the relationship between mevalonate metabolism, cholesterol homeostasis and T cell function.
Slow sintering in garnet‐containing Y and Gd zirconate–aluminate mixtures for thermal barrier coatings
Authors: Yu Yueh‐Cheng , Godbole Eeshani P. , Berrios Josselyne , Hewage Nethmi , Poerschke David L. 
Published: March 2023

AbstractMixtures of rare‐earth zirconates and aluminates containing Y or Y + Gd that form a two‐phase garnet–fluorite mixture exhibit much slower sintering than pure fluorite at 1400°C. An equivalent Y‐free, Gd‐containing composition that forms a perovskite aluminate instead of garnet showed faster densification after the metastable garnet decomposes. At 1500°C, the Y‐free sample also showed the fastest initial sintering rate, whereas there was more divergence in the sintering rate for the samples containing Y + Gd. The zirconate–aluminate with equimolar Y + Gd shows the slowest densification at 1500°C and retains ∼25% porosity after 250 h. The results highlight possibilities for designing compliant thermal barrier coatings that can retain significant porosity at 1400°C or higher.
Interpreting alignment to the EAT‐Lancet diet using dietary intakes of lactating mothers in rural Western Kenya
Authors: Quarpong Wilhemina , Wakoli Samson , Oiye Shadrack , Williams Anne M. 
Published: March 2023

AbstractThe EAT‐Lancet reference diet intends to be good for planetary and human health. We compared single multiple pass method 24‐h dietary intake of mothers (n = 242) from a cross‐sectional study in Western Kenya to the recommended range of intake of 11 EAT‐Lancet food groups (e.g., 0–100 g/day legumes; maximum score 11), defining alignment two ways: daily intake among food groups where a minimum intake of 0 g was either acceptable or unacceptable. Ordinal logistic regression models assessed associations between alignment and body mass index (BMI). Cost of mothers' diets and hypothetical diets within recommended ranges (lower bounds >0 g) were estimated using food price data from markets within the mothers' locality. Mean energy intake was 1827 (95% confidence interval [CI]: 1731–1924) kcal/day. Relative to the EAT‐Lancet diet, mothers' diets were on average higher for grains; within recommendations for tubers, fish, beef and dairy; closer to lower bounds for chicken, eggs, legumes and nuts; and lower for fruits and vegetables. Mean (95% CI) alignment scores were 8.2 (8.0–8.3) when 0 g intakes were acceptable and 1.7 (1.6–1.9) otherwise. No significant associations were found between alignment and BMI. Mothers' diets and hypothetical diets within recommended ranges averaged 184.6 KES (1.6 USD) and 357.5 KES (3.0 USD)/person/day, respectively. Lactating mothers' diets were not diverse and diverged from the reference diet when an intake of 0 g was considered unacceptable. Lower bound intakes of 0 g for micronutrient‐dense food groups are inappropriate in food‐insecure populations. It would likely cost more than mothers currently spend to tailor their diets to the EAT‐Lancet reference diet.
Inbreeding depression in an outbred stickleback population
Authors: Fraimout Antoine , Rastas Pasi , Lv Lei , Merilä Juha 
Published: March 2023

AbstractInbreeding depression refers to the reduced fitness of offspring produced by genetically‐related individuals and is expected to be rare in large, outbred populations. When it occurs, marked fitness loss is possible as large populations can carry a substantial load of recessive harmful mutations which are normally sheltered at the heterozygous state. Using experimental cross data and genome‐wide identity‐by‐descent (IBD) relationships from an outbred marine nine‐spined stickleback (Pungitius pungitius) population, we documented a significant decrease in offspring survival probability with increasing parental IBD sharing associated with an average inbreeding load (B) of 10.5. Interestingly, we found that this relationship was also underlined by a positive effect of paternal inbreeding coefficient on offspring survival, suggesting that certain combinations of parental inbreeding and genetic relatedness among mates may promote offspring survival. Our results demonstrate the potential for substantial inbreeding load in an outbred population and emphasize the need to consider fine‐scale genetic relatedness in future studies of inbreeding depression in the wild.
Proposed guidelines for appropriate utilization of superficial radiation therapy in management of skin cancers. Zemtsov‐Cognetta criteria
Authors: Zemtsov Alexander , Cognetta Armand , Marvel John , Logan Ann 
Published: March 2023

AbstractObjectiveTo develop appropriate use criteria (AUC) for the treatment of basal cell and squamous cell carcinoma by superficial radiation therapy (SRT) technique.Material and MethodsDelphi‐type discussion of the experts.ResultsPresented in Figure 1.ConclusionThese AUCs are in compliance both with the position statement of the American Academy of Dermatology (AAD) and the ASTRO Clinical Practice Guideline on this subject. It is further recommended that SRT will be only performed by either a dermatologist who is board certified in Mohs surgery (MDS) and who had adequate SRT training or by radiation oncologists. Hopefully, this publication will stimulate further discussion on this topic.
Data Supplement from Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells
Authors: Izumi Hideki , Kaneko Yasuhiko 
Published: March 2023

<p>Supplementary Figure S10. Trim32 ubiquitinylates MYCN in vitro. Trim32 in TGW cells with or without nocodazole treatment (30ng/ml for 16h) was immunoprecipitated by an anti-Trim32 antibody, and mixed with recombinant GST-MYCN. Then, an in vitro ubiquitinylation assay was performed. Ubiquitinylation ability of Trim32 was active both in interphase and mitosis. Since the ubiquitin ligase activity of Trim32 was inhibited by phosphorylation of PKA in interphase as reported recently (2), Trim32 may be more active in mitosis rather than in interphase. 2.	Ichimura T, Taoka M, Shoji I, Kato H, Sato T, Hatakeyama S, et al. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. Journal of cell science. 2013;126:2014-26.</p>
Blockchain and Bank Lending Behavior: A Theoretical Analysis
Authors: Wang Rui 
Published: March 2023

The application of blockchain technology in the financial industry has become the focus of global attention; thus, the traditional credit business of commercial banks faces unprecedented opportunities and challenges. Based on the theoretical analysis, this study systematically examines the dynamic impact of blockchain on the lending behavior of commercial banks. The results indicate that, in the case of interest rate marketization, the blockchain expands bank credit through the mechanism of “reducing management costs”; in the case that interest rates have not yet been marketized, the blockchain can also increase bank lending through the channel of “correcting the price of funds” by narrowing the difference between the market equilibrium and the bank deposit interest rate. The results are of great significance for a deeper understanding of the impact and mechanism of blockchain on bank credit. JEL codes: G21; O31; O33
Critical review on quality of methodology and recommendations of clinical practice guidelines for peri-implantitis
Authors: Yin Qiaofeng , Liang Jingyi , Zhang Yuhang , Chen Canxiong , Yu Weiming , Wang Xiaoyi , Ji Jianxin 
Published: March 2023

Abstract
Background
Peri-implantitis is of high prevalence with the popularity of dental implants nowadays. Guidelines or consensus have been developed in succession, and we are little-known about their quality. The objective of this study is to evaluate the methodological quality of these guidelines and analyze the consistency of the clinical recommendations.

Methods
We searched for guidelines or consensus on prevention, diagnosis, and/or treatment of peri-implantitis through PubMed, Web of Science, Cochrane Library until January 15th, 2022. In addition, we also searched the websites of the American Dental Association, International Team for Implantology, FDI World Dental Federation, and some guideline collection databases. Appraisal of Guidelines for Research & Evaluation II methodological quality instrument was used to assess the selected guidelines. Furthermore, we described the consistency of recommendations across the included guidelines.

Results
In total, 15 guidelines were included. The mean values of the six domains score all below 50%. The mean scores of Applicability were lowest (mean:15%, range:4–29%). As to the overall quality, eleven (73%) were recommended after being modified, and four (27%) were not recommended. Among the clinical recommendations, 53 (67.09%) are for treatment of peri-implantitis, 13 (16.46%) for monitoring issue, 7 (8.86%) for diagnosis, 3 (3.80%) for the disease prevention.

Conclusions
Improving methodology quality and strengthening clinical evidence is essential in the future guideline development in a range of disciplines for improving the treatment effectiveness of people with peri-implantitis. And there is a lack of integrated guidelines in the case of the COVID-19 pandemic.
Family caregivers as essential partners in care: examining the impacts of restrictive acute care visiting policies during the COVID-19 pandemic in Canada
Authors: Montesanti Stephanie , MacKean Gail , Fitzpatrick Kayla M. , Fancott Carol 
Published: March 2023

Abstract
Introduction
During the pandemic many Canadian hospitals made significant changes to their ‘open family presence’ and ‘visitor policies’ to reduce the spread of COVID-19 by instituting restrictive or ‘zero visiting’ policies in healthcare facilities. These policies have the potential to create great hardship, anxiety and stress for patients, families, caregivers and frontline healthcare providers (HCPs); along with concerns about the quality and safety of patient care. The presence of family members and other caregivers as essential partners in care is an explicit expression of the philosophy of patient- and family-centred care (PFCC) in action. The purpose of this study is to increase our understanding of how changes to family presence and visiting policies and practices during the COVID-19 pandemic have impacted patients, family caregivers and frontline healthcare providers (HCPs) in acute care hospitals.

Methods
A total of 38 in-depth semi-structured interviews were conducted with patients, family caregivers and HCPs in Canadian provinces who had experience with visiting policies in acute care settings during the pandemic. COVID patients, and the caregivers of COVID patients, were excluded from this study. A maximum variation sampling strategy was used to guide the selection and recruitment of patients, family caregivers and HCPs, based on our interest in gaining a diversity of perspectives and experiences.

Results
Many patients, family caregivers, and HCPs view family caregiver presence as integral to PFCC, describing the essential roles played by family caregivers prior to the pandemic. There were commonalities across all three groups with respect to their perspectives on the impacts of restrictive visiting policies on patients, family caregivers and HCPs. They fell into four broad integrated categories: (1) emotional and mental health; (2) communication and advocacy; (3) safety and quality of care; and (4) PFCC, trust in the healthcare system, and future decisions regarding accessing needed healthcare. Recommendations for pandemic visiting policies were also identified.

Conclusions
The findings from this study highlighted several impacts of restrictive family caregiver presence or visiting policies implemented during COVID-19 on patients, family caregivers and HCPs in acute healthcare settings across Canada. Participants emphasized that there is no “one-size-fits-all” caregiver presence policy that will address all patient needs. To be consistent with the practice of PFCC, patients and family caregivers are welcomed as part of the healthcare team in ways that work for them, demonstrating that flexibility in family presence and visiting policies is essential.
High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes
Authors: Németh Krisztina , Tóth Blanka , Sarnyai Farkas , Koncz Anna , Lenzinger Dorina , Kereszturi Éva , Visnovitz Tamás , Kestecher Brachyahu Meir , Osteikoetxea Xabier , Csala Miklós , Buzás Edit I. , Tamási Viola 
Published: March 2023

Abstract
Background
High fat diet (HFD) increases the likelihood of dyslipidemia, which can be a serious risk factor for atherosclerosis, diabetes or hepatosteatosis. Although changes in different blood lipid levels were broadly investigated, such alterations in the liver tissue have not been studied before. The aim of the current study was to investigate the effect of HFD on hepatic triglyceride (TG), diglyceride (DG) and ceramide (CER) levels and on the expression of four key genes involved in lipid homeostasis (Pcsk9, Ldlr, Cd36 and Anxa2) in the liver. In addition, the potential role of PCSK9 in the observed changes was further investigated by using PCSK9 deficient mice.

Methods
We used two in vivo models: mice kept on HFD for 20 weeks and PCSK9−/− mice. The amount of the major TGs, DGs and CERs was measured by using HPLC–MS/MS analysis. The expression profiles of four lipid related genes, namely Pcsk9, Ldlr, Cd36 and Anxa2 were assessed. Co-localization studies were performed by confocal microscopy.

Results
In HFD mice, hepatic PCSK9 expression was decreased and ANXA2 expression was increased both on mRNA and protein levels, and the amount of LDLR and CD36 receptor proteins was increased. While LDLR protein level was also elevated in the livers of PCSK9−/− mice, there was no significant change in the expression of ANXA2 and CD36 in these animals. HFD induced a significant elevation in the hepatic levels of all measured TG and DG but not of CER types, and increased the proportion of monounsaturated vs. saturated TGs and DGs. Similar changes were detected in the hepatic lipid profiles of HFD and PCSK9−/− mice. Co-localization of PCSK9 with LDLR, CD36 and ANXA2 was verified in HepG2 cells.

Conclusions
Our results show that obesogenic HFD downregulates PCSK9 expression in the liver and causes alterations in the hepatic lipid accumulation, which resemble those observed in PCSK9 deficiency. These findings suggest that PCSK9-mediated modulation of LDLR and CD36 expression might contribute to the HFD-induced changes in lipid homeostasis.
Psoralidin inhibits osteosarcoma growth and metastasis by downregulating ITGB1 expression via the FAK and PI3K/Akt signaling pathways
Authors: Cheng Shengwen , Liu Senrui , Chen Bowen , Du Chengcheng , Xiao Pengcheng , Luo Xuefeng , Wei Li , Lei Yiting , Zhao Chen , Huang Wei 
Published: March 2023

Abstract
Background
Psoralea corylifolia is a medicinal leguminous plant that has long been used to treat various diseases. Psoralidin (PSO) is the main extract compound of P. corylifolia and exhibits antibacterial, antitumor, anti-inflammatory, antioxidant, and other pharmacological activities. PSO has demonstrated inhibitory effects in several cancers; however, its inhibitory effect on osteosarcoma has not been reported. This study aimed to evaluate the inhibitory effect of PSO on osteosarcoma and elucidate the underlying molecular mechanisms.

Methods
Crystal violet, cell counting kit-8 (CCK8), and 5-Ethynyl-2′-deoxyuridine (EdU) staining assays were used to assess the inhibitory effect of PSO on the proliferation of 143B and MG63 osteosarcoma cells. Wound healing and Transwell assays were conducted to evaluate the effects of PSO on osteosarcoma cell migration and invasion. The cell cycle and apoptosis were analyzed using flow cytometry. To determine the possible molecular mechanisms, RNA-sequencing was performed and protein expression was analyzed by western blotting. The inhibitory effect of PSO on osteosarcoma in vivo was analyzed using a mouse model of orthotopic osteosarcoma and immunohistochemistry.

Results
PSO inhibited osteosarcoma cell proliferation in a concentration-dependent manner, inhibited cell migration and invasion, and induced cell-cycle arrest and apoptosis. Mechanistically, PSO treatment significantly inhibited the focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways by downregulating ITGB1 expression in both MG63 and 143B cells. Furthermore, we demonstrated that PSO restrained osteosarcoma growth in vivo.

Conclusion
PSO may suppress osteosarcoma via the FAK and PI3K/Akt signaling pathways by downregulating ITGB1 expression.
Clinical decision support to Optimize Care of patients with Atrial Fibrillation or flutter in the Emergency department: protocol of a stepped-wedge cluster randomized pragmatic trial (O’CAFÉ trial)
Authors: Vinson David R. , Rauchwerger Adina S. , Karadi Chandu A. , Shan Judy , Warton E. Margaret , Zhang Jennifer Y. , Ballard Dustin W. , Mark Dustin G. , Hofmann Erik R. , Cotton Dale M. , Durant Edward J. , Lin James S. , Sax Dana R. , Poth Luke S. , Gamboa Stephen H. , Ghiya Meena S. , Kene Mamata V. , Ganapathy Anuradha , Whiteley Patrick M. , Bouvet Sean C. , Babakhanian Leon , Kwok Edward W. , Solomon Matthew D. , Go Alan S. , Reed Mary E. ,   on behalf of the Kaiser Permanente CREST Network
Published: March 2023

Abstract
Background
Management of adults with atrial fibrillation (AF) or atrial flutter in the emergency department (ED) includes rate reduction, cardioversion, and stroke prevention. Different approaches to these components of care may lead to variation in frequency of hospitalization and stroke prevention actions, with significant implications for patient experience, cost of care, and risk of complications. Standardization using evidence-based recommendations could reduce variation in management, preventable hospitalizations, and stroke risk.

Methods
We describe the rationale for our ED-based AF treatment recommendations. We also describe the development of an electronic clinical decision support system (CDSS) to deliver these recommendations to emergency physicians at the point of care. We implemented the CDSS at three pilot sites to assess feasibility and solicit user feedback. We will evaluate the impact of the CDSS on hospitalization and stroke prevention actions using a stepped-wedge cluster randomized pragmatic clinical trial across 13 community EDs in Northern California.

Discussion
We hypothesize that the CDSS intervention will reduce hospitalization of adults with isolated AF or atrial flutter presenting to the ED and increase anticoagulation prescription in eligible patients at the time of ED discharge and within 30 days. If our hypotheses are confirmed, the treatment protocol and CDSS could be recommended to other EDs to improve management of adults with AF or atrial flutter.

Trial registration
ClinicalTrials.gov NCT05009225. Registered on 17 August 2021.