bluuebunny/crossref_metadata_2025_split huggingface dataset:
A wearable 3D pressure sensor based on electrostatic self-assembly MXene/chitosan sponge and insulating PVP spacer
Authors: Liu Zerui , Zhang Yulin , Song Yuxiang , Lu Yong , Liu Ting , Zhang Jicai 
Published: June 2023

Abstract
It has been shown that flexible pressure sensors may be used in many different contexts, including human-machine interaction, intelligent robots, and health monitoring. In this work, we create a 3D sponge piezoresistive pressure sensor using MXene, chitosan, polyurethane sponge, and polyvinyl pyrrolidone (MXene/CS/PU sponge/PVP), with the well-conductive MXene nanosheet serving as the force sensitive material. In particular, the mechanical strength and endurance of the sensor are enhanced by electrostatic self-assembly between the negatively charged MXene nanosheets and the positively charged CS/PU composite sponge skeleton. The insulating PVP nanowires (PVP-NWs) also decreases the device’s initial current, increasing the sensor’s sensitivity. These characteristics allow the pressure sensor to simultaneously have a high sensitivity (50.27 kPa−1 for pressure below 7 kPa and 13.3 kPa−1 for pressure between 7 and 16 kPa), a quick response time (160 ms), a short recovery time (130 ms), and excellent cycling stability (5000 cycles). Moreover, the sensor exhibits a waterproof performance, where the force-sensitive layer still works normally after cleaning. In practice, the sensor could detect a variety of human actions as well as the distribution of spatial pressure due to the above superior device performance.
2D vanadium disulfide nanosheets assisted ultrasensitive, rapid, and label-free electrochemical quantification of cancer biomarker (MMP-2)
Authors: Ghosh Tanmoya Nemai , Rotake Dinesh Ramkrushna , Singh Shiv Govind 
Published: June 2023

Abstract
Cancer is one of the most tormenting global health burdens reporting high mortality and morbidity worldwide. Matrix metalloproteinase 2 (MMP-2) protein has elevated expression for most types of cancers, including prostate and breast cancer. Therefore, accurate and specific detection of MMP-2 biomarker is crucial for screening, treatment, and prognosis of related cancer. In this work, we have proposed a label-free electrochemical biosensor for the detection of MMP-2 protein. This biosensor was fabricated using hydrothermally synthesized vanadium disulfide (VS2) nanosheets with monoclonal anti-MMP2 antibodies biofunctionalized using a suitable linker. The VS2 nanomaterials were synthesized hydrothermally at different reaction temperatures (140 °C, 160 °C, 180 °C and 200 °C) generating different morphologies from a 3D bulk cubic structure at 140 °C to 2D nanosheets at 200 °C. Owing to the advantages of 2D VS2 nanosheets with high surface-to-volume ratio, excellent electrochemical response and high antibody loading possibility, it was selected for fabricating an MMP-2 specific biosensor. The antibody–antigen binding event is analyzed by recording electrochemical impedance spectroscopy signals for different target MMP-2 protein concentrations. The sensitivity and lower limit of detection were 7.272 (ΔR/R)(ng ml)−1 cm−2 and 0.138 fg ml−1, respectively in 10 mM phosphate buffer saline for this proposed sensor. Further, interference studies were also performed which demonstrates the sensor to be highly selective against non-specific target proteins. This 2D VS2 nanosheet-based electrochemical biosensor is a sensitive, cost-effective, accurate, and selective solution for cancer diagnosis.
Ion acceleration with few-cycle relativistic laser pulses from foil targets
Authors: Ter-Avetisyan Sargis , Varmazyar Parvin , Singh Prashant K , Son Joon-Gon , Fule Miklos , Bychenkov Valery Yu , Farkas Balazs , Nelissen Kwinten , Mondal Sudipta , Papp Daniel , Börzsönyi Adam , Csontos Janos , Lécz Zsolt , Somoskői Tamas , Tóth Laszló , Tóth Szabolcs , Andriy Velyhan , Margarone Daniele , Necas Ales , Mourou Gerard , Szabó Gabor , Osvay Karoly 
Published: June 2023

Abstract
Ion acceleration resulting from the interaction of 11 fs laser pulses of

∼

35 mJ energy with ultrahigh contrast (<10−10) and 1019 W cm−2 peak intensity with foil targets made of various materials and thicknesses at normal (0°) and 45° laser incidence is investigated. The maximum energy of the protons reached ∼1.4 MeV accelerated in the laser propagation direction and ∼1.2 MeV in the opposite direction from a formvar target. The energy conversion efficiency from the laser to the proton beam is estimated to be as high as ∼1.4% at 45° laser incidence using a 51 nm thick

Al

target. The high laser contrast indicates the predominance of vacuum heating via Brunel’s effect as an absorption mechanism involving a tiny pre-plasma at the target front. The experimental results are in reasonable agreement with theoretical estimates, where proton acceleration from the target front side in the backward direction is well explained by the Coulomb explosion of a charged cavity formed in a tiny pre-plasma, while forward proton acceleration is likely to be a two-step process: protons are first accelerated in the target front-side cavity and then further boosted in energy through the target back side via the target normal sheath acceleration (TNSA) mechanism.
Projective synchronization of the generalized Lotka-Volterra system with asymptotically unbounded external disturbance
Authors: Li Yanping , Guo Rongwei , Liu Lixia 
Published: June 2023

Abstract
This paper investigates the projective synchronization problem of the generalized Lotka-Volterra (GLV) system in the presence of asymptotically unbounded external disturbances. Firstly, an unified projective synchronization control law is proposed for the nominal GLV system, which verified the existence of the projective synchronization problem. Secondly, two suitable filters are designed to estimate the asymptotically unbounded external disturbances that are incorporated into GLV system, by which a simple yet general disturbance estimator (DE)-based control strategy is derived to achieve the asymptotically stable of the error system. Finally, numerical simulations are performed to demonstrate the correctness and validity of the theoretical results.
Machine learning based performance estimation of terrestrial Ro-FSO Link
Authors: Kaur Sanmukh , Singh Shiv Kumar , Sharma Aanchal 
Published: June 2023

Abstract
In this work, a radio over free-space optical communication (Ro-FSO) link has been examined considering quadrature amplitude modulation (64-QAM) based orthogonal frequency division multiplexing (OFDM) technique for a turbulence channel. The performance of the system has been investigated considering log normal and gamma-gamma atmospheric scintillation models under clear air, rain and fog weather conditions. Artificial neural network (ANN), k-nearest neighbour (KNN), and decision tree (DT) machine learning (ML) techniques have been applied for estimation of quality of received signal in terms of bit error rate BER. ANN model exhibits the highest value of R-squared (R2) of 0.9967 and lowest value of root mean square error (RMSE) of 0.0134 as compared to other ML techniques resulting in the best fit model.
Fully chaotic medical image encryption scheme based on dynamic DNA and block rotation
Authors: Xiong Jie , Ji’e Musha , Wang Lidan , Duan Shukai 
Published: June 2023

Abstract
As an important application of image encryption, digital medical image encryption plays an important role in the field of medical health and privacy protection. This paper put forwards a fully chaotic and strongly plaintext associated image encryption framework based on an improved chaotic system, block rotation and DNA computing. The algorithm generates multiple chaotic sequences by using different one-dimensional seed chaotic maps under the sine transform framework for subsequent block rotation, DNA dynamic encoding and decoding, generating key images for DNA XOR calculation. Simulation experiments and comparative analysis have shown that this algorithm can achieve fantastic encryption performance, resist various attacks, and have higher security levels and good generalization performance.
Early warning signals for critical transitions in complex systems
Authors: George Sandip V , Kachhara Sneha , Ambika G 
Published: June 2023

Abstract
In this topical review, we present a brief overview of the different methods and measures to detect the occurrence of critical transitions in complex systems. We start by introducing the mechanisms that trigger critical transitions, and how they relate to early warning signals (EWS) and briefly mention the conventional measures based on critical slowing down, as computed from data and applied to real systems. We then present in detail the approaches for multivariate data, including those defined for complex networks. More recent techniques like the warning signals derived from the recurrence pattern underlying the data, are presented in detail as measures from recurrence plots and recurrence networks. This is followed by a discussion on how methods based on machine learning are used most recently, to detect critical transitions in real and simulated data. Towards the end, we summarise the challenges involved while computing the EWS from real-world data and conclude with our outlook and perspective on future trends in this area.
Improving adaptation to wildfire smoke and extreme heat in frontline communities: evidence from a community-engaged pilot study in the San Francisco Bay Area
Authors: Herbert Natalie , Beckman Caroline , Cannedy Cade , Cao Jinpu , Cho Seung-Hyun , Fischer Stephanie , Huang ShihMing , Kramer Samantha J , Lopez Ortensia , Lopez Sergio Sanchez , Ouyang Derek , Suckale Jenny , Wulf-Saena Violet , Zhang Zhihao , Wong-Parodi Gabrielle 
Published: June 2023

Abstract
Exposure to climate hazards is increasing, and the experiences of frontline communities warrant meaningful and urgent attention towards how to mitigate, manage, and adapt to hazards. We report results from a community-engaged pilot (November 2021–June 2022) of N = 30 participants in four frontline communities of the San Francisco Bay Area, California, USA. The study region is an area where low-income, non-English-speaking residents are inequitably exposed and vulnerable to wildfire smoke, extreme heat, and other climate hazards. Building from a yearslong partnership of researchers, community organizations, and community members, we report the feasibility of a project piloting (1) instruments to monitor indoor air quality, temperature, and participant sleep health, and (2) interventions to improve indoor air quality and support protective behaviors. Data collection included experience-based survey data (via in-person administered surveys and a smartphone application) and interviews about heat and air quality, as well as data from an air monitoring protocol. Results cover the prevalence of hazard exposure and protective actions among participants. We discuss throughout methods for conducting and evaluating a community-engaged pilot, particularly by using a community ambassador program. Implications include the feasibility of community-engaged research projects, including discussion of resources required to accomplish this work.
Rain-fed to irrigation-fed transition of agriculture exacerbates meteorological drought in cropped regions but moderates elsewhere
Authors: Kim Sungyoon , Kumar Mukesh , Kam Jonghun 
Published: June 2023

Abstract
In recent decades, irrigated agriculture has expanded dramatically over the Southeastern United States (SEUS). The trend is more likely to continue in future given the need to further improve crop productivity and its resilience against droughts, however, the impact of these SEUS land cover changes remains unknown. This study investigates how and to what extent rain-fed to irrigation-fed (RFtoIF) transition in the SEUS region modulates precipitation spatially and temporally under a severe drought meteorological condition. In this study, we perform three Weather Research Forecasting model simulations with varying degrees of irrigated crop areas with meteorological boundary conditions of a record-breaking 2007 drought in the SEUS region. Results show that the SEUS irrigation expansion reduces both the convective triggering potential and low-level humidity index through land-atmospheric interaction. This is accompanied by reduction in the height of atmospheric boundary layer (ABL)-lifting condensation level crossing and increase in the convective available potential energy. These modulations within the ABL provide a favorable condition for strong deep convection during the drought period. However, the impact on precipitation is heterogeneous, with crop areas undergoing RFtoIF transition experiencing an overall reduction in precipitation while other landcovers experiencing an increase. The reduction in precipitation over RFtoIF transitioned croplands is in part due to moisture redistribution aided by generation of an anomalous high-pressure system. The results highlight the complexity of response of precipitation to irrigation expansion in the SEUS, and underscore the need to perform spatially-explicit analysis for mitigating risks to water resources and food security.
The dermatologist’s guide to beards: a review of structure, function, care and pathology
Authors: Boothby-Shoemaker Wyatt , Comeau Nicholas , Daveluy Steven 
Published: June 2023

AbstractFacial hair is a commonly desired feature for many individuals. Despite a breadth of dermatology literature covering strategies for removing facial hair, there are no known articles summarizing strategies for facial hair growth or reviewing common facial hair pathologies. Here, we assess Google Trends to describe significant increases in search terms related to facial hair growth and maintenance over the last decade, suggesting an increased public interest in this topic. Next, we review ethnic differences that may affect facial hair distribution, growth, and predisposition to certain facial hair pathologies. Lastly, we review studies on agents used for facial hair growth and review common facial hair pathologies.
Spatiotemporal dynamics across visual cortical laminae support a predictive coding framework for interpreting mismatch responses
Authors: Gallimore Connor G , Ricci David A , Hamm Jordan P 
Published: June 2023

Abstract
Context modulates neocortical processing of sensory data. Unexpected visual stimuli elicit large responses in primary visual cortex (V1)—a phenomenon known as deviance detection (DD) at the neural level, or “mismatch negativity” (MMN) when measured with EEG. It remains unclear how visual DD/MMN signals emerge across cortical layers, in temporal relation to the onset of deviant stimuli, and with respect to brain oscillations. Here we employed a visual “oddball” sequence—a classic paradigm for studying aberrant DD/MMN in neuropsychiatric populations—and recorded local field potentials in V1 of awake mice with 16-channel multielectrode arrays. Multiunit activity and current source density profiles showed that although basic adaptation to redundant stimuli was present early (50 ms) in layer 4 responses, DD emerged later (150–230 ms) in supragranular layers (L2/3). This DD signal coincided with increased delta/theta (2–7 Hz) and high-gamma (70–80 Hz) oscillations in L2/3 and decreased beta oscillations (26–36 Hz) in L1. These results clarify the neocortical dynamics elicited during an oddball paradigm at a microcircuit level. They are consistent with a predictive coding framework, which posits that predictive suppression is present in cortical feed-back circuits, which synapse in L1, whereas “prediction errors” engage cortical feed-forward processing streams, which emanate from L2/3.
Skills, Not Just Knowledge: Infectious Diseases Fellows’ Recommendations Regarding Antimicrobial Stewardship Training
Authors: Wasson Megan K , Luther Vera P , Armstrong Wendy S , Schwartz Brian S , Shnekendorf Rachel , Logan Ashleigh , Bennani Kenza , Spicer Jennifer O 
Published: June 2023

Abstract

Background
Antimicrobial stewardship (AS) is an important topic in infectious diseases (ID) training, yet many ID fellowships lack formal training, and little is known about fellows’ learning preferences.

Methods
We conducted 24 in-depth interviews with ID fellows across the United States during 2018 and 2019 to explore their experiences with and preferences for AS education during fellowship. Interviews were transcribed, deidentified, and analyzed to identify themes.

Results
Fellows had variable exposure to AS before and during fellowship, which impacted their knowledge about and attitude toward stewardship as a career; however, all fellows expressed the importance of learning general stewardship principles during fellowship. Some fellows’ training included mandatory stewardship lectures and/or rotations, but most fellows felt their primary stewardship learning occurred through informal experiences in the clinical setting, such as holding the antimicrobial approval pager. Fellows expressed a preference for a standardized, structured curriculum that included in-person practical, interactive discussions with multidisciplinary faculty along with the opportunity to practice and apply their skills; however, they emphasized that time needed to be set aside for those educational activities. Although they wanted to learn the evidence and rationale for stewardship recommendations, they especially wanted training in and feedback on how to communicate stewardship recommendations to other health professionals, particularly in the setting of conflict.

Conclusions
ID fellows believe that standardized AS curricula should be included in their fellowship training, and they prefer structured, practical, and interactive learning experiences.
Global Differences in the Management of Staphylococcus aureus Bacteremia: No International Standard of Care
Authors: Westgeest Annette C , Buis David T P , Sigaloff Kim C E , Ruffin Felicia , Visser Leo G , Yu Yunsong , Schippers Emile F , Lambregts Merel M C , Tong Steven Y C , de Boer Mark G J , Fowler Vance G 
Published: June 2023

Abstract

Background
Despite being the leading cause of mortality from bloodstream infections worldwide, little is known about regional variation in treatment practices for Staphylococcus aureus bacteremia (SAB). The aim of this study was to identify global variation in management, diagnostics, and definitions of SAB.

Methods
During a 20-day period in 2022, physicians throughout the world were surveyed on SAB treatment practices. The survey was distributed through listservs, e-mails, and social media.

Results
In total, 2031 physicians from 71 different countries on 6 continents (North America [701, 35%], Europe [573, 28%], Asia [409, 20%], Oceania [182, 9%], South America [124, 6%], and Africa [42, 2%]) completed the survey. Management-based responses differed significantly by continent for preferred treatment of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) bacteremia, use of adjunctive rifampin for prosthetic material infection, and use of oral antibiotics (P &lt; .01 for all comparisons). The 18F-FDG PET/CT scans were most commonly used in Europe (94%) and least frequently used in Africa (13%) and North America (51%; P &lt; .01). Although most respondents defined persistent SAB as 3–4 days of positive blood cultures, responses ranged from 2 days in 31% of European respondents to 7 days in 38% of Asian respondents (P &lt; .01).

Conclusions
Large practice variations for SAB exist throughout the world, reflecting the paucity of high-quality data and the absence of an international standard of care for the management of SAB.
Cost-Effectiveness Analysis of Increased Adalimumab Dose Intervals in Crohn’s Disease Patients in Stable Remission: The Randomized Controlled LADI Trial
Authors: Jansen Fenna M , van Linschoten Reinier C A , Kievit Wietske , Smits Lisa J T , Pauwels Renske W M , de Jong Dirk J , de Vries Annemarie C , Boekema Paul J , West Rachel L , Bodelier Alexander G L , Gisbertz Ingrid A M , Wolfhagen Frank H J , Römkens Tessa E H , Lutgens Maurice W M D , van Bodegraven Adriaan A , Oldenburg Bas , Pierik Marieke J , Russel Maurice G V M , de Boer Nanne K , Mallant-Hent Rosalie C , ter Borg Pieter C J , van der Meulen-de Jong Andrea E , Jansen Jeroen M , Jansen Sita V , Tan Adrianus C I T L , Hoentjen Frank , van der Woude C Janneke ,   LADI study group, van Noord Desirée , Hoekstra Jildou , Kamphuis Johannes T , Gorter Moniek H P , van Esch Aura A J 
Published: June 2023

Abstract

Background and Aims
We aimed to assess cost-effectiveness of increasing adalimumab dose intervals compared to the conventional dosing interval in patients with Crohn’s disease [CD] in stable clinical and biochemical remission.

Design
We conducted a pragmatic, open-label, randomized controlled non-inferiority trial, comparing increased adalimumab intervals with the 2-weekly interval in adult CD patients in clinical remission. Quality of life was measured with the EQ-5D-5L. Costs were measured from a societal perspective. Results are shown as differences and incremental net monetary benefit [iNMB] at relevant willingness to accept [WTA] levels.

Results
We randomized 174 patients to the intervention [n = 113] and control [n = 61] groups. No difference was found in utility (difference: −0.017, 95% confidence interval [−0.044; 0.004]) and total costs (−€943, [−€2226; €1367]) over the 48-week study period between the two groups. Medication costs per patient were lower (−€2545, [−€2780; −€2192]) in the intervention group, but non-medication healthcare (+€474, [+€149; +€952]) and patient costs (+€365 [+€92; €1058]) were higher. Cost–utility analysis showed that the iNMB was €594 [−€2099; €2050], €69 [−€2908; €1965] and −€455 [−€4,096; €1984] at WTA levels of €20 000, €50 000 and €80 000, respectively. Increasing adalimumab dose intervals was more likely to be cost-effective at WTA levels below €53 960 per quality-adjusted life year. Above €53 960 continuing the conventional dose interval was more likely to be cost-effective.

Conclusion
When the loss of a quality-adjusted life year is valued at less than €53 960, increasing the adalimumab dose interval is a cost-effective strategy in CD patients in stable clinical and biochemical remission.

Clinical Trial Registration Number
ClinicalTrials.gov, number NCT03172377.
AUXIN RESPONSIVE FACTOR8 regulates development of the feeding site induced by root-knot nematodes in tomato
Authors: Noureddine Yara , da Rocha Martine , An Jing , Médina Clémence , Mejias Joffrey , Mulet Karine , Quentin Michaël , Abad Pierre , Zouine Mohamed , Favery Bruno , Jaubert-Possamai Stéphanie 
Published: June 2023

Abstract
Root-knot nematodes (RKN) from the genus Meloidogyne induce the dedifferentiation of root vascular cells into giant multinucleate feeding cells. These feeding cells result from an extensive reprogramming of gene expression, and auxin is known to be a key player in their development. However, little is known about how the auxin signal is transmitted during giant cell development. Integrative analyses combining transcriptome and small non-coding RNA datasets with the specific sequencing of cleaved transcripts identified genes targeted by miRNAs in tomato (Solanum lycopersicum) galls. The two auxin-responsive transcription factors ARF8A and ARF8B, and their miRNA167 regulators, were identified as robust gene–miRNA pair candidates to be involved in the tomato response to M. incognita. Spatiotemporal expression analysis using promoter–β-glucuronidase (GUS) fusions showed the up-regulation of ARF8A and ARF8B in RKN-induced feeding cells and surrounding cells. The generation and phenotyping of CRISPR (clustered regularly interspaced palindromic repeats) mutants demonstrated the role of ARF8A and ARF8B in giant cell development and allowed the characterization of their downstream regulated genes.