bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual mechanical impact of β-escin on model lipid membranes
Authors: Moleiro Lara H. , Martín-Romero María T. , Herráez-Aguilar Diego , Santiago José A. , Caselli Niccolo , Dargel Carina , Geisler Ramsia , Hellweg Thomas , Monroy Francisco 
Published: June 2023

ABSTRACTUsing artificially reconstituted membranes based on structurally liquidlike phospholipids, we have performed an experimental study on the mechanical impact of the saponin β-aescin, aka escin, a natural biosurfactant extracted from the seeds of the horse chestnut treeAesculus hippocastanum. The paper focusses on the modulable interaction of escin with DMPC in model membranes in the form of bilayer vesicles and Langmuir monolayers. As regarding to their dual mechanical membrane behavior being both soft solids and viscoelastic fluids, we have outlined the principal energetic and kinetic features describing the insertion of escin as transversally adsorbed or longitudinally integrated within the model membranes. At connection with the structural phase behavior assessed by dedicated microscopies of surface fluorescence and Brewster angle reflectivity, these hybrid escin / phospholipid membranes have been revealed to possess dual mechanical properties connected to their structural rigidness and fluidity behaving both in one way and another. In particular, we observe a soft glassy rheology typical for liquid-crystalline ordered phases at low temperature, which turns into a fluidlike viscoelasticity characteristic of the disordered phases at high physiological temperature. These original results have been discussed in a physicochemical perspective that may pave new avenues of material engineering and / or pharmacological design exploiting the dual mechanical impact of escin as a mechanical modulator of the cellular membrane.
Influence of elevated temperature on compressive strength of LD slag aggregate concrete
Authors: Singh Prince , Prasad Brajkishor , Kumar Virendra 
Published: June 2023

PurposeThis study aims to investigate the compressive strength of concretes incorporating Linz-Donawitz slag (LD slag) as partial replacement for natural fine and coarse aggregates and compare them with traditional concrete.Design/methodology/approachThe natural fine and coarse aggregates were replaced by weight simultaneously up to 100% with LD slag aggregates at an incremental increase of 20%. Concrete of grades M20, M25, M30, M35 and M40 were cast, cured and tested with standard cube specimens to study the density and compressive strength of reference and LD slag aggregate concretes (LDSACs). The concrete specimens were exposed to elevated temperatures, i.e. 100 to 900 °C at an equal interval of 100 °C and tested to study the variation in density and residual compressive strength.FindingsThe results from the experiments reveal that the LDSAC yields a higher density than that of the reference concrete and also undergo less density variation when exposed to elevated temperatures. In addition, the residual compressive strength of LDSAC specimens was significantly higher than that of the reference concrete.Research limitations/implicationsLD slag is believed to be stronger and more durable than locally available limestone aggregates or blast furnace slag. Moreover, it is necessary to study its strength and other properties to determine whether it can be successfully used as an aggregate in concrete universally.Practical implicationsUse of LD slag as aggregates in concrete will convert LD slag into a value added product and as an alternative to the existing natural aggregates which will help in maintaining ecological balance and save valuable lands.Social implicationsThe economically weaker section of the society may now use LDSAC as waste utilization will bring down the overall cost and hence it will benefit people on large scale.Originality/valueUse of LD slag as aggregate in concrete can help find an alternative to the existing natural aggregates which will save the ecosystem and at the same time help in reducing the industrial waste on a large scale.
Workplace ostracism: a qualitative enquiry
Authors: Dash Sanket , Ranjan Sushant , Bhardwaj Neha , Rastogi Siddhartha K. 
Published: June 2023

PurposeThe study aims to understand the phenomenon of workplace ostracism from multiple perspectives (target, perpetrator and observer). The understanding of the phenomenon is used to thematically analyse the antecedents of workplace ostracism and identify appropriate strategies for each antecedent.Design/methodology/approachThe study findings are based on face-to-face semi-structured interviews with thirty-three senior and medium-level employees from various public and private sector organizations in India. The interview transcripts were systematically analyzed to identify antecedents of ostracism, which were inductively grouped together based on similarity.FindingsThe antecedents of workplace ostracism were grouped into four major heads: perceived non-alignment with organizational needs; emotional reaction; unconscious social processes and structural and demographic differences. Based on interview transcripts, strategies to reduce the effect of each of the broad antecedents of ostracism were identified.Practical implicationsWorkplace ostracism has been linked with multiple negative outcomes including increased stress and turnover intention. The study provides managers with a framework that enables them to evaluate and understand incidences of ostracism among their subordinates. The study also equips managers with the knowledge of specific strategies for dealing with specific antecedents of ostracism.Originality/valueThe study answers the need to look at the phenomenon of ostracism through multiple perspectives. It identifies multiple potentially new antecedents and strategies to deal with workplace ostracism and groups them in a coherent manner. It is among the few studies on ostracism in India and extends the generalizability of the construct.
The dual-level effects of authentic leadership on teacher wellbeing: the mediating role of psychological availability
Authors: Xu Zhihua , Yang Fu 
Published: June 2023

PurposeDrawing on the conservation of resources (COR) theory, this study examined the mediating role of psychological availability in the relationships between principals' individual-level and group-level authentic leadership and individual teachers' wellbeing, that is, job satisfaction, life satisfaction and emotional exhaustion.Design/methodology/approachThe authors conducted a three-wave online questionnaire survey among 266 teachers from 52 schools in China. Multilevel structural equation modeling (MSEM) was used to analyze the hypothesized relationships among the study variables.FindingsThe principals' group-level and individual-level authentic leadership were both positively associated with individual teachers' psychological availability, which in turn was positively related to their job satisfaction and life satisfaction, and negatively related to their emotional exhaustion.Practical implicationsSchool administrations should elevate the levels of principals' authentic leadership by selecting and developing authentic principals to increase teacher wellbeing.Originality/valueDiffering from prior research that has focused on the effect of authentic leadership at either group-level or individual-level, this study simultaneously investigated the dual-level effects of principals' authentic leadership. Moreover, psychological availability was found to mediate the dual-level effects of principals' authentic leadership on teachers' job satisfaction, life satisfaction and emotional exhaustion.
Generalizability of nociception level as a measure of intraoperative nociceptive stimulation: A retrospective analysis
Authors: Ruetzler Kurt , Montalvo Mateo , Rotem Omer Miller , Ekrami Elyad , Rössler Julian , Duran Jorge Andres Araujo , Dahan Albert , Gozal Yaacov , Richebe Philippe , Farhang Borzoo , Turan Alparslan , Sessler Daniel I. 
Published: June 2023

AbstractBackgroundNociception‐guided intraoperative opioid administration might help reduce postoperative pain. A commonly used and validated nociception monitor system is nociception level (NOL), which provides the nociception index, ranging from 0 to 100, with 0 representing no nociception and 100 representing extreme nociception. We tested the hypothesis that NOL responses are similar in men and women given remifentanil and fentanyl, across various types of anesthesia, as a function of American Society of Anesthesiologists physical status designations, and over a range of ages and body morphologies.MethodsWe conducted a retrospective cohort analysis of trial data from eight prospective NOL validation studies. Among 522 noncardiac surgical patients enrolled in these studies, 447 were included in our analysis. We assessed NOL responses to various noxious and non‐noxious stimuli.ResultsThe average NOL in response to 315 noxious stimuli was 47 ± 15 (95% CI = 45–49). The average NOL in response to 361 non‐noxious stimuli was 10 ± 12 (95% CI = 9–11). NOL responses were similar in men and women, in patients given remifentanil and fentanyl, across various types of anesthesia, as a function of American Society of Anesthesiologists physical status designations, and over a range of ages and body morphologies.ConclusionNociception level appears to provide accurate estimates of intraoperative nociception over a broad range of patients and anesthetic conditions.
Guselkumab for the treatment of patients with moderate‐to‐severe hidradenitis suppurativa: A phase 2 randomized study
Authors: Kimball Alexa B. , Podda Maurizio , Alavi Afsaneh , Miller Megan , Shen Yaung‐Kaung , Li Shu , Xu Yan , Han Chenglong , Fakharzadeh Steven , Yang Ya‐Wen , DePrimo Samuel , Munoz Ernesto , Chen Yanqing , Passeron Thierry , Papp Kim 
Published: June 2023

AbstractBackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin condition that causes substantial physical, emotional and psychological burdens. Guselkumab, a monoclonal antibody that binds to the p19 subunit of interleukin‐23, has demonstrated high levels of efficacy in the treatment of inflammatory diseases, including psoriasis and psoriatic arthritis.ObjectiveTo evaluate the effect of guselkumab on the treatment of HS, a phase 2, multicentre, randomized, placebo‐controlled, double‐blind, proof‐of‐concept study was conducted.MethodsPatients ≥18 years of age with moderate‐to‐severe HS for ≥1 year were randomized to (1) guselkumab 200 mg by subcutaneous (SC) injection every 4 weeks (q4w) through Week 36 (guselkumab SC); (2) guselkumab 1200 mg intravenously (IV) q4w for 12 weeks, then switched to guselkumab 200 mg SC q4w from Weeks 12 through 36 (guselkumab IV); or (3) placebo for 12 weeks, with re‐randomization to guselkumab 200 mg SC q4w at Weeks 16 through 36 (placebo → guselkumab 200 mg) or guselkumab 100 mg SC at Weeks 16, 20, 28 and 36 and placebo at Weeks 24 and 32 (placebo → guselkumab 100 mg). End points included HS clinical response (HiSCR) and patient‐reported outcomes.ResultsAlthough guselkumab SC or guselkumab IV resulted in numerically higher HiSCR versus placebo at Week 16 (50.8%, 45.0%, 38.7%, respectively), statistical significance was not achieved. Numerically greater improvements in patient‐reported outcomes were also observed for guselkumab SC and guselkumab IV versus placebo at Week 16. Through Week 40, no clear differences to suggest a dose response were observed for HiSCR and patient‐reported outcomes.ConclusionsDespite modest improvements, the primary end point was not met and the overall findings do not support the efficacy of guselkumab in the treatment of HS. Clinicaltrials.gov: NCT 03628924.
Methotrexate for inflammatory skin disease in pediatric patients: Consensus treatment guidelines
Authors: Siegfried Elaine C. , Arkin Lisa M. , Chiu Yvonne E. , Hebert Adelaide A. , Callen Jeffrey P. , Castelo‐Soccio Leslie , Co Dominic O. , Cordoro Kelly M. , Curran Megan L. , Dalrymple Austin M. , Flohr Carsten , Gordon Ken B. , Hanna Diane , Irvine Alan D. , Kim Susan , Kirkorian A. Yasmine , Lara‐Corrales Irene , Lindstrom Jill , Paller Amy S. , Reyes Melissa , Begolka Wendy Smith , Tom Wynnis L. , Van Voorhees Abby S. , Vleugels Ruth Ann , Lee Lara Wine , Davies Olivia M. T. , Brandling‐Bennett Heather A. 
Published: June 2023

AbstractMethotrexate (MTX) is a readily accessible drug, first used in 1948 and employed for a wide variety of indications since then. However, despite widespread off‐label use, FDA labeling does not include approved indications for the use of MTX for many inflammatory skin diseases in pediatric patients, including morphea, psoriasis, atopic dermatitis, and alopecia areata, among others. Without published treatment guidelines, some clinicians may be hesitant to use MTX off‐label, or uncomfortable prescribing MTX in this population. To address this unmet need, an expert consensus committee was convened to develop evidence‐ and consensus‐based guidelines for use of MTX to treat pediatric inflammatory skin disease. Clinicians with experience and expertise in clinical research, drug development, and treating inflammatory skin disease in pediatric patients with MTX were recruited. Five committees were created based on major topic areas: (1) indications and contraindications, (2) dosing, (3) interactions with immunizations and medications, (4) adverse effects (potential for and management of), and (5) monitoring needs. Pertinent questions were generated and addressed by the relevant committee. The entire group participated in a modified Delphi process to establish agreement on recommendations for each question. The committee developed 46 evidence‐ and consensus‐based recommendations, each with >70% agreement among members, across all five topics. These are presented in tables and text, along with a discussion of supporting literature, and level of evidence. These evidence‐ and consensus‐based recommendations will support safe and effective use of MTX for the underserved population of pediatric patients who may benefit from this valuable, time‐honored medication.
Exploring the pedagogical practices of seasoned elementary mathematics teachers and connections with their content knowledge and beliefs
Authors: Auslander Susan Swars , Myers Kayla D. , Bingham Gary E. , Tanguay Carla L. 
Published: June 2023

AbstractThis inquiry examined the pedagogical practices in mathematics of elementary teachers (N = 27) who had been identified as experienced and successful and were working in an urban school district with underserved student populations. Also investigated were relationships between their instructional practices and other elements of proficient teaching of mathematics, including specialized content knowledge and beliefs. Quantitative and qualitative data were collected via a knowledge assessment, belief surveys, classroom observations, and individual interviews. The findings related to learner‐centered, equitable mathematics instruction reveal a mixed picture of understanding and enactment by the participants, illuminating variability and complexity, especially within the context of a standardized model for instructional delivery. Participants expressed constraints in implementing learner‐centered, equitable mathematics instruction, particularly: prescribed, scripted lesson plans; teaching roles that involved instruction of many students thus contributing to lack of familiarity; and a mix of learners who were in‐class and remote due to the COVID‐19 pandemic. The results also demonstrate that pedagogical practices were shaped by participants’ specialized content knowledge and to a more limited extent their beliefs. These data further reveal mixed endorsements of the different belief constructs. Considerations for teacher development are discussed.
Biological variation of biochemical urine and serum analytes in healthy dogs
Authors: Selin Anna K. , Lilliehöök Inger , Forkman Johannes , Larsson Anders , Pelander Lena , Strage Emma M. 
Published: June 2023

AbstractBackgroundBiological variation (BV) of urinary (U) biochemical analytes has not been described in absolute terms, let alone as a ratio of the U‐creatinine or fractional excretion in healthy dogs. These analytes are potential diagnostic tools for different types of kidney damage and electrolyte disorders in dogs.ObjectivesWe aimed to investigate the BV of specific gravity, osmolality, creatinine, urea, protein, glucose, chloride, sodium, potassium, calcium, and phosphate in urine from healthy pet dogs.MethodsBlood and urine samples from 13 dogs were collected once weekly for 8 weeks. Samples were analyzed in duplicate and in randomized order. For each sample, U‐analyte and serum concentrations were measured, and U‐analyte/U‐creatinine and fractional excretion (FE) were calculated. Components of variance, estimated by restricted maximum likelihood, were used to determine within‐subject variation (CVI), between‐subject variation (CVG), and analytical variation (CVA). Index of individuality (II) and reference change values were calculated.ResultsCVI for all urine analytes varied between 12.6% and 35.9%, except for U‐sodium, U‐sodium/U‐Cr, and FE‐sodium, which had higher CVIs (59.5%‐60.7%). For U‐protein, U‐sodium, U‐potassium, U‐sodium/U‐creatinine, FE‐urea, FE‐glucose, FE‐sodium, FE‐potassium, and FE‐phosphate II were low, indicating that population‐based RIs were appropriate. The remaining analytes had an intermediate II, suggesting that population‐based RIs should be used with caution.ConclusionThis study presents information on the biological variation of urinary and serum biochemical analytes from healthy dogs. These data are important for an appropriate interpretation of laboratory results.
Multipath Impact on Multi-Frequency and Multi-Constellation Code Measurements from Brazilian GNSS Stations
Authors: Setti Jr. Paulo T. , Silva Crislaine Menezes da , Alves Daniele Barroca Marra , Vieira João Vitor Espinhosa , Zaupa João Pedro Voltare 
Published: June 2023

Although Global Navigation Satellite Systems (GNSS) positioning can achieve high accuracy in line-of-sight conditions, multipath remains a dominant source of error. Multipath occurs when the reflected signals reach the receiver in addition to the direct ones. Different systems design can impact the multipath effect, such as the signal modulation and chipping rate. In the context of multifrequency and multi-constellation scenario that we are achieving with four operational global constellations, this paper compares the multipath impact in different signals of GPS, GLONASS, Galileo and BeiDou. For the experiment, one week of data from 35 Brazilian Network for Continuous Monitoring of the GNSS Systems (RBMC) stations in June 2021 was processed. The multipath index was estimated based on the code- inus-carrier combination. For the first frequency of each system, similar results were obtained for GPS, GLONASS and BeiDou (approximately 56 cm). The Galileo BOC/AltBOC modulation offers better resistance to multipath, with a multipath index of 37 cm for E1 and of 12 cm for E5. Considering all selected stations, the multipath index of GPS L1 varied from 38 cm to 61 cm.
Thinking About Elite Performance: The Experience and Impact of Mental Fatigue in Elite Sport Coaching
Authors: Russell Suzanna , Halson Shona L. , Jenkins David G. , Rynne Steven B. , Roelands Bart , Kelly Vincent G. 
Published: June 2023

Purpose: Mental fatigue causes decreases in aspects of athletes’ performance. Elite coaches commonly undertake cognitively demanding tasks and are seemingly at similar risk of subsequent performance impairment. However, elite sport coaches’ experiences of mental fatigue, alongside other markers of psychobiological stress, have yet to be quantified. Methods: Three elite coaching and performance staff (2 women and 1 man) provided 100-mm visual analog scale ratings of mental fatigue, physical fatigue, readiness to perform, and salivary samples for later cortisol (sCort) and alpha-amylase (sAA) analysis. Data were obtained on the same morning each week across a 16-week preseason. Data were subset by individual coach for descriptive and repeated-measures correlational analyses. Results: Fluctuating mental fatigue was observed over the 16 weeks (min–max; coach 1 = 25–86 AU; coach 2 = 0–51 AU; and coach 3 = 15 − 76 AU). Elevated levels of mental fatigue were reported at multiple time points, with individual variability observed. sCort (in nanomoles per liter), sAA (in micromoles per liter), and sAA:sCort indicated that coaches experienced psychophysiological stress (min–max; coach 1 sCort = 8.42–17.31, sAA = 52.40–113.06, sAA:sCort = 3.20–12.80; coach 2 sCort = 4.20–9.70, sAA = 158.80–307.20, sAA:sCort = 21.10–61.70; and coach 3 sCort = 6.81−19.66, sAA = 86.55–495.85, sAA:sCort = 4.90–35.50). A significant inverse relationship between mental fatigue and readiness to perform (r = −.44 [−.64 to −.17], P = .002) was identified. Conclusions: Elite sport coaches report elevated instances of mental fatigue during a preseason training period. Those involved in elite sports should act to understand the presence and potential subsequent impacts of staff mental fatigue and consider management or mitigation strategies. Optimization of the cognitive performance of coaches and performance staff presents as a potential source of competitive advantage.
Community-based alcohol education intervention (THEATRE) study to reduce harmful effects of alcohol in rural Sri Lanka: design and adaptation of a mixed-methods stepped wedge cluster randomised control trial
Authors: Pearson Melissa , Dawson Andrew , Raubenheimer Jacques , Senerathna Lalith , Conigrave Katherine , Lee K S Kylie , Rajapakse Thilini , Pushpakumara Pahala Hangidi Gedara Janaka , Siribaddana Sisira , Soerensen Jane Brandt , Konradsen Flemming , Jan Stephen , Dawson Angela J , Buckley Nicholas , Abeysinghe Ranil , Siriwardhana Prabash , Priyadarshana Chamil , Haber Paul S , Dzidowska Monika , Abeykoon Palitha , Glozier Nick 
Published: June 2023

IntroductionAlcohol consumption is a leading cause of mortality, morbidity and adverse social sequelae in Sri Lanka. Effective community-based, culturally adapted or context-specific interventions are required to minimise these harms. We designed a mixed-methods stepped wedge cluster randomised control trial of a complex alcohol intervention. This paper describes the initial trial protocol and subsequent modifications following COVID-19.Methods and analysisWe aimed to recruit 20 villages (approximately n=4000) in rural Sri Lanka. The proposed intervention consisted of health screening clinics, alcohol brief intervention, participatory drama, film, and public health promotion materials to be delivered over 12 weeks.Following disruptions to the trial resulting from the Easter bombings in 2019, COVID-19 and a national financial crisis, we adapted the study in two main ways. First, the interventions were reconfigured for hybrid delivery. Second, a rolling pre–post study evaluating changes in alcohol use, mental health, social capital and financial stress as the primary outcome and implementation and ex-ante economic analysis as secondary outcomes.Ethics and disseminationThe original study and amendments have been reviewed and granted ethical approval by Rajarata University of Sri Lanka (ERC/2018/21—July 2018 and February 2022) and the University of Sydney (2019/006). Findings will be disseminated locally in collaboration with the community and stakeholders.The new hybrid approach may be more adaptable, scalable and generalisable than the planned intervention. The changes will allow a closer assessment of individual interventions while enabling the evaluation of this discontinuous event through a naturalistic trial design. This may assist other researchers facing similar disruptions to community-based studies.Trial registrationThe trial is registered with the Sri Lanka Clinical Trials Registry;https://slctr.lk/trials/slctr-2018-037.