bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of genetic variation influencing metformin response in a multi-ancestry genome-wide association study in the Diabetes Prevention Program (DPP)
Authors: Li Josephine , Perry James A. , Jablonski Kathleen A. , Srinivasan Shylaja , Chen Ling , Todd Jennifer N. , Harden Maegan , Mercader Josep M. , Pan Qing , Dawed Adem Y. , Yee Sook Wah , Pearson Ewan R. , Giacomini Kathleen M. , Giri Ayush , Hung Adriana M. , Xiao Shujie , Williams L. Keoki , Franks Paul W. , Hanson Robert L. , Kahn Steven E. , Knowler William C. , Pollin Toni I. , Florez Jose C. , Group Diabetes Prevention Program Research 
Published: January 2023

<p>Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not replicated in the Diabetes Prevention Program (DPP). To assess pharmacogenetic interactions in pre-diabetes, we conducted a genome-wide association study (GWAS) in the DPP. Cox proportional hazards models tested associations with diabetes incidence in metformin (MET, n=876) and placebo (PBO, n=887) arms. Multiple linear regression assessed association with one-year change in metformin-related quantitative traits, adjusted for baseline trait, age, sex, and 10 ancestry principal components. We tested for gene-by-treatment interaction. No significant associations emerged for diabetes incidence. We identified four genome-wide significant variants after correcting for correlated traits (<em>p</em><9×10-9). In MET, rs144322333 near <em>ENOSF1 </em>(minor allele frequency [MAF]AFR=0.07, MAFEUR=0.002) was associated with an increase in % glycated hemoglobin (per minor allele β=0.39 [95% CI 0.28, 0.50], <em>p</em>=2.8×10-12). Rs145591055 near <em>OMSR</em> (MAF=0.10 in American Indians), was associated with weight loss (kg) (per G allele β=-7.55 [95% CI -9.88, -5.22], <em>p</em>=3.2×10-10) in MET. Neither variant was significant in PBO; gene-by-treatment interaction was significant for both variants (<em>p(G×T)</em><1.0×10-4). Replication in individuals with diabetes did not yield significant findings. A GWAS for metformin response in pre-diabetes revealed novel ethnic-specific associations that require further investigation but may have implications for tailored therapy. <br>
</p>
Supervisi Klinis untuk Meningkatkan Komitmen Kerja Guru
Authors: Ratnadi Ni Luh 
Published: January 2023

Komitmen kerja menjadi salah satu faktor penentu keberhasilan kerja seseorang pegawai termasuk guru. Hanya saja kenyataan di lapangan menunjukkan bahwa komitmen kinerja guru masih rendah, sehingga membutuhkan supervisi klinis sebagai bentuk pengawasan kepala sekolah. Adapun tujuan dari penelitian ini yakni untuk mengetahui peningkatan komitmen kerja guru melalui proses supervisi klinis. Penelitian ini tergolong ke dalam penelitian tindakan kelas yang dilaksakan dalam dua siklus penelitian. Pada masing-masing siklus penelitian terdapat empat tahapan pelaksanaan yang terdiri atas perancanaan tindakan, pelaksanaan tindakan, pengamatan/observasi, dan proses refleksi. Subjek yang terlibat dalam penelitian ini yakni 16 orang guru sekolah dasar. Pengumpulan data dalam penelitian dilakukan dengan menggunakan metode kuesioner dengan instrumen berupa lembar angket komitmen kerja guru yang dibuat menggunakan skala likert 1-5 sehingga data yang diperoleh berupa skor. Data yang diperoleh dalam penelitian kemudian dianalisis dengan menggunakan teknik analisis data analisis statistik yaitu metode analisis statistik dektiptif dan metode analisis statistik inferensial. Hasil analisis penelitian menunjukkan bahwa rata-rata prasiklus sebesar 128,56 dengan kategori sedang, meningkat pada siklus I rata-ratanya menjadi 151,25 dengan kategori tinggi, dan meningkat lagi pada siklus II rata-ratanya menjadi 176,81 dengan kategori sangat tinggi. Berdasarkan hasil tersebut, dapat disimpulkan bahwa penerapan supervisi klinis secara efektif dapat meningkatkan komitmen kerja guru sekolah dasar.
Model Pembelajaran Kooperatif Tipe Talking Stick untuk Meningkatkan Hasil Belajar Agama Hindu pada Siswa Kelas VI Sekolah Dasar
Authors: Astikajaya I Made 
Published: January 2023

Rendahnya hasil belajar siswa disebabkan karena lingkungan belajar yang diciptakan oleh guru tidak berhasil membuat siswa sebagai peserta didik dalam belajar. Penelitian ini bertujuan menganalisis model pembelajaran kooperatif tipe talking stick dapat meningkatkan hasil belajar agama Hindu pada siswa kelas VI SD. Jenis penelitian ini adalah penelitian tindakan kelas yang melibatkan siswa kelas V yang berjumlah 13 orang siswa. Pengumpulan data hasil belajar siswa dengan tes hasil belajar. Metode analisis data dengan analisis deskriptif kuantitatif. Hasil penelitian ini menunjukan bahwa hasil belajar mata pelajaran Agama Hindu melalui penerapan model pembelajaran kooperatif tipe Talking stick pada siswa kelas VI dinyatakan meningkat. Hal dibuktikan terjadi peningkatan hasil belajar antara siklus I (jumlah 945, rata-rata 73, daya serap 73%, ketuntasan belajar 69%) dan siklus II (jumlah 1075, rata-rata 83, daya serap 83%, ketuntasan belajar 100%). Terjadi peningkatan hasil belajar antara siklus I dan siklus II, menunjukan kenaikan rata-rata daya serap 10% dan pada ketuntasan belajar mengalami kenaikan sebesar 31%. Kesimpulan penerapan model pembelajaran kooperatif tipe Talking stick pada siswa kelas VI SD dapat meningkatkan hasil belajar Agama Hindu. Implikasi penelitian ini diharapkan dapat membantu guru dalam proses pembelajaran dan membantu siswa untuk meningkatkan hasil belajar melalui model pembelajaran yang menyenangkan.
Arabic Practice in the Language Environment l Mumarasah al-Lughah al-‘Arabiyah fi Bi’ah Lughawiyyah
Authors: Kasmantoni Kasmantoni , Aflisia Noza , ‘Atiyah Isma Muhammad 
Published: January 2023

The concept of learning speaking skills was urgently discussed to become a cornerstone in practice. Many students do not understand correctly the concept of speaking Arabic which is the characteristic of someone who is proficient in Arabic. The purpose of this study was to analyze the idea of Mohammed Mohammed Imam Daoud in learning speaking skills in Arabic Language. A qualitative descriptive method was used as the research design. Data analysis techniques included formulating research problems, conducting literature studies, determining units of observation and units of analysis, creating categorization and coding guidelines, coding data, and processing data. The results of the research that the ability to be tired of the meanings of the soul in different approvals and the ability to use vocabulary in the social context. The method of speaking skill was according to Muhammad Daoud's approach to listening skill and speaking skill. Adab of learning the speaking skills are fidelity, seriousness in training, and continuous, so the learners would be skillful. The information would make knowledge but training and practice would create skill cooperation with the teacher and colleagues and humility in their lives. The key of success in speaking can also be done with the application of Arabic in the language environment. Muhammad Imam Dawood's idea of teaching speaking skills was important for developing the quality of learning speaking skills at the primary, intermediate and advanced levels. The application of Arabic in practice would increase the fluently in speaking performance.
Students' Responses and Perceptions in Learning Strategy of Ilmu al-Badi Based on Mind Maps l Istijabat al-Talabah wa Tasawuratihim fi Tatbiq Istiratijiyyah Ta’lim ‘Ilmi al-Badi’ al-Qaimah ‘ala al-Kharait al-Dzihniyyah
Authors: Hamzah Hamzah , Fattah Abd. , Khaira Boukhari 
Published: January 2023

The Learning situation during the pandemic of Covid-19 was very concerning and giving impact on students' understanding. Mind Map strategy is one of the most effective ways to streamline and improve the quality of learning. This study aimed to determine the extent to which students' responses and perceptions in implementing mind map-based Arabic language learning strategies for students of the Arabic Language and Literature Department fifth semester of Sekolah Tinggi Agama Islam Negeri Majene, West Sulawesi. This research was classified as a quantitative research with a survey research design. The data source for this research was students of the Department of Arabic Language and Literature in the fifth semester of Sekolah Tinggi Agama Islam Negeri Majene, West Sulawesi. The data collection was carried out through interviews with respondents and using a questionnaire which was distributed to respondents after learning using the mind map strategy. The data analysis used was descriptive and a Likert scale was used to measure and to identify qualitative and quantitative data. The results of this study were students' responses to the learning strategies of ilmu Badi' based on mind maps increased their grade significantly. Student's perception of the learning strategy stated they understood the material easier, more efficient, and more enjoyable. They were given time to understand the material. These results confirmed the previous studies results and became recommendation about the application of a Mind Map strategy in learning which was efficient and able to increase students' understanding.
Integrating Technology into Education: Students' Attitudes toward Online Learning
Authors: Mahyiddin Mahyiddin , Amin Fakhrurrazi M. 
Published: January 2023

The increasing spread of the COVID-19 encouraged learning systems to switch from traditional to online learning. It has brought significant problems and difficulties for students. The swift shift to fully online learning demands some adaptation. Students must learn to adapt their abilities because of the increasing use of technology in education. This study explored students' attitudes towards online learning and the reasons for their attitudes. A survey of 191 students from four State Islamic universities in Aceh was conducted online. A descriptive research framework was chosen, and a survey approach was used to collect data to gain knowledge of the situation and answer research questions. Students showed a positive attitude and satisfaction toward online learning during Covid-19. Even they realized how to handle technological tools applied during teaching and learning. Integrating technology into education does not challenge students as technical support and facilitates education to be easier. Keeping up with technology and infrastructural upgrades is vital to support online learning. The recent study has certain limitations. The small number of participants leads to incomplete data. Therefore, it is necessary to include more people to examine education in general.
MODEL KEBIJAKAN PEMERINTAH DAERAH DALAM PENGEMBANGAN PASAR TRADISIONAL UNTUK MENINGKATKAN DAYA SAING TERHADAP PASAR MODERN
Authors: Qohar Abd , Abdul Wakhid Ali , Faizal Liky 
Published: January 2023

Persaingan antara pasar modern di dengan pasar tradisional semakin tak terkendali akhir-akhir ini di Kota Bandar Lampung. Di Kota Bandar Lampung terdapat sekitar 14 toko modern yang setiap Tahun nya jumlahnya meningkat sementara jumlah pasar tradisional sebanyak 10 buah. Dengan munculnya berbagai macam pasar modern di yang telah menjamur di seluruh wilayah Kota Bandar Lampung memberikan berbagai dampak baik positif maupun negatif bagi masyarakat. Dampak positif yang diberikan antara lain mempermudah akses masyarakat mendapatkan barang konsumsi yang mereka butuhkan karena supermarket dan minimarket memiliki kelengkapan barang-barang kebutuhan sehari-hari. Selain itu letaknya yang berada dekat dengan pemukiman maupun akses jalan membuat supermarket minimarket mudah dijangkau.Penelitian ini adalah penelitian lapangan (field research) yaitu memaparkan dan menggambarkan keadaan serta fenomena yang lebih jelas mengenai situasi yang terjadi. Penelitian ini bertujuan untuk mempelajari secara intensif tentang kebijakan pemerintah daerah dalam pengembangan pasar tradisional untuk meningkatkan daya saing terhadap pasar modern di Kota Bandar Lampung. Data primer untuk penelitian ini adalah berupa data dari hasil wawancara dengan pegawai Dinas Perdagangan Kota Bandar Lampung. Dalam penelitian ini data sekunder yang berkaitan kebijakan pemerintah daerah dalam pengembangan pasar tradisional untuk meningkatkan daya saing terhadap pasar modern di Kota Bandar Lampung.Pihak yang menjadi informan utama dalam penelitian ini adalah pihak-pihak yang terlibat dalam kebijakan pemerintah daerah dalam pengembangan pasar tradisional untuk meningkatkan daya saing terhadap pasar modern di Kota Bandar Lampung, sedangkan pihak-pihak lain yang terkait dengan kebijakan pemerintah daerah dalam pengembangan pasar tradisional untuk meningkatkan daya saing terhadap pasar modern di Kota Bandar Lampung menjadi informan tambahan. Adapun kegiatan pengumpulan data dilakukan setelah penelitian dilakukan atau disusun. Pengumpulan data merupakan salah satu proses dalam penelitian yang dapat membantu memecahkan permasalahan yang sedang diteliti, oleh karena itu data yang dikumpulkan harus cukup Analisis data dengan mengumpulkan data, redukasi data, penyajian data, dan kesimpulan.Hasil penelitian yaitu Pemerintah Kota Bandar Lampung telah mengambil berbagai model kebijakan sebagai upaya untuk mengembangkan pasar tradisional dalam rangka menghadapi maraknya pasar modern. Dan telah juga melakukan berbagai beberapa program pengembangan pasar telah dilaksanakan seperti: revitalisasi pasar tradisional melalui perbaikan sarana prasarana pendukung pasar tradisional, pemberdayaan pasar dan pengembangan dan pembuatan media promosi pasar.
TINJAUAN FIQH SIYASAH TERHADAP PROBLEMATIKA PEGAWAI HONORER
Authors: Amelia A.Lapaja Futri , Hamiyuddin  , Sapruddin  
Published: January 2023

As part of the Palu Region XII Production Forest Management Agency, the performance of honorary employees has its own problems. Poor performance will result in not optimal service and quality of related agencies. Fiqh siyasah as binoculars to see how the performance of BPHP Region XII Palu honorary employees in the eyes of Islamic government law. Based on the fiqh siyasa review of the Problems of Honorary Employees at the Production Forest Management Office for Region XII Palu, it cannot be said that it is in accordance with the principles of fiqh siyasa. Because there are still Honorary employees who are not trustworthy and do not carry out their duties properly. The performance of honorary employees should be in accordance with the principles of good governance, namely justice, leaving those that are not of use value, ukhuwah, and trustworthiness. BPHP Region XII Palu agency and honorary employees who are there must be able to work together in an effort so that problems in these agencies can be resolved properly by means of the BPHP Region XII Palu must always find solutions for honorary employees who do not get promoted and honorary employees at the institution must improve performance more effectively and better.
Abstrak
Sebagai salah satu bagian dari instansi Balai Pengelolaan Hutan Produksi Wilayah XII Palu, kinerja pegawai honorer memiliki problematika tersendiri. Kinerja yang buruk akan berakibat pada tidak maksimalnya pelayanan dan kualitas instansi terkait. Fiqh siyasah sebagai teropong untuk melihat bagaimana kinerja pegawai honor BPHP Wilayah XII Palu dalam kacamata hukum pemerintahan islam. Berdasarkan tinjauan fiqh siyasah terhadap Problematika Pegawai Honorer Pada Balai Pengelolaan Hutan Produksi Wilayah XII Palu, belum dapat dikatakan bersesuaian dengan prinsip fiqh siyasah. Karena masih adanya pegawai Honorer yang tidak amanah dan tidak melaksanakan tugasnya dengan baik. Seharusnya kinerja dari pegawai honorer sesuai dengan asas-asas tata kelola pemerintahan yang baik, yaitu keadilan, meninggalkan yang tidak bernilai guna, ukhuwah, dan amanah. Instansi BPHP Wilayah XII Palu dan pegawai honorer yang ada di sana harus bisa bekerja sama mengupayakan agar permasalahan di instansi tersebut dapat teratasi dengan baik dengan cara pihak BPHP Wilayah Xii Palu harus selalu mencari solusi untuk pegawai honorer yang tidak kunjung terangkat dan pegawai honorer di instasi tersebut harus meningkatkatkan kinerja lebih efektif dan baik lagi.
KEMURNIAN HAKIM ADHOK PADA SISTEM PERADILAN HUBUNGAN INDUSTRIAL DI INDONESIA
Authors: Daryono  
Published: January 2023

The purpose of this study is to examine the purity of ad-hoc judges in the Industrial Relations Justice system in Indonesia. This study uses a normative legal research method with a statute and comparative approach. The results of the study show that the position of ad hoc judges as executor of judicial power, who should be free to enforce law and justice, is different from that of ad hoc judges at the Industrial Relations Court whose position is regulated in Law No. 2 of 2004 concerning Industrial Relations Dispute Settlement (UU-PPHI). The position of ad hoc judges at the Industrial Relations Court is tied to each of the proposing organizations, either Workers/Labourers' organizations or employers' organization, which causes the position of an ad hoc Judges, in the industrial relations judicial system to be less independent, due to the requirements of the interests of each proposing organization. In fact, the existence of ad-hoc judges in the judicial system is expected to be able to create a sense of community justice.
Abstrak
Tujuan studi ini untuk mengkaji Kemurnian Hakim Ad-hoc pada sistem Peradilan Hubungan Industrial di Indonesia. Studi ini menggunakan metode penelitian hukum normatif dengan pendekatan perundang-undangan dan komparatif. Hasil studi menunjukkan bahwa Kedudukan hakim Ad-hoc sebagai pelaksana Kekuasaan Kehakiman, yang seharusnya bebas merdeka dalam menegakan hukum dan keadilan, namun berbeda halnya dengan Hakim Ad hoc pada Pengadilan Hubungan Industrial yang kedudukannya diatur dalam Undang-Undang No. 2 Tahun 2004 tentang Penyelesaian Perselisihan Hubungan Industrial (UU-PPHI), Kedudukan Hakim Ad hoc pada Pengadilan Hubungan Industrial ternyata terikat dengan masing-masing organisasi pengusul, baik organisasi Pekerja/Buruh atau organisasi pengusaha, yang menyebabkan kedudukan Hakim Ad hoc dalam sistem peradilan hubungan industrial menjadi tidak independen, karena syarat kepentingan dari masing-masing organisasi pengusul. Padahal keberadaan hakim ad-hoc pada sistem Peradilan diharapkan mampu menciptakan rasa keadilan masyarakat.
Comparison of four endotracheal tube cleaning protocols in anesthetized dogs
Authors: Marquis Charlotte R. , Gull Tamara , Dodam John , Thombs Lori , Bukoski Alex 
Published: January 2023

Abstract

OBJECTIVE
To compare the efficacy of 4 cleaning protocols applied to endotracheal tubes (ETTs) collected from anesthetized dogs.

SAMPLE
100 ETTs (25 per protocol).

PROCEDURES
A 10-question survey designed to determine ETT reuse and cleaning practices was distributed via email to a sample of veterinary anesthesiologists. Informed by survey results, 4 ETT cleaning protocols were selected for use in a prospective clinical study. Dogs were intubated with sterile polyvinyl chloride ETTs. At extubation, each ETT was cultured for bacterial growth, randomly assigned to 1 of 4 protocols [water scrub (P1), detergent scrub (P2), detergent scrub and chlorhexidine gluconate (CHG) soak (P3), or detergent scrub and bleach soak (P4)], and cultured again after drying. Bacterial genera were identified using mass spectrometry and 16s rRNA sequencing. Proportions of ETTs exhibiting no post-cleaning growth were compared between protocols using the Fisher exact test with Bonferroni correction.

RESULTS
Half of survey respondents that reused ETTs did not sterilize them before reuse, cleaning methods varied widely, and no reported methods were evidence-based. After use, the number of ETTs exhibiting no post-cleaning bacterial growth were 15/25 (60%), 14/25 (56%), 20/25 (80%), and 17/25 (68%) for protocols P1, P2, P3, and P4, respectively. Pairwise comparisons did not reveal any statistically significant differences between protocols.

CLINICAL RELEVANCE
In small animal patients, some veterinary anesthesiologists reuse ETTs without sterilization and cleaning protocols vary widely. No differences between the studied protocols were identified. Further research is necessary to identify a safe, efficacious ETT cleaning protocol for use in small animal practice.
Sedated cesarean sections are associated with increased kid survival compared to general anesthesia in goats: retrospective cohort of 45 cases (2011–2021)
Authors: Elane George L. , Portela Diego A. , Hobbs Kallie J. , Bauck Anje G. , Biedrzycki Adam H. 
Published: January 2023

Abstract

OBJECTIVE
To determine whether anesthesia type (sedation or general anesthesia) affects kid survival to discharge in caprine cesarean sections (C-sections).

ANIMALS
Retrospective cohort of 99 caprine C-sections (2011–2021).

PROCEDURES
All surgeries were performed via left flank laparotomy in right lateral recumbency. The number of kids alive at presentation, surgery, and discharge was recorded. Kids that were dead on presentation or euthanized intraoperatively were excluded. Goats were classified as “healthy” (American Society of Anesthesiologists status ≤ 2) or “sick” (≥ 3).

RESULTS
Kid survival was significantly higher for C-sections performed under sedation (47/52 [90%]) than for C-sections performed under general anesthesia (16/24 [66%]; P = .004). Relative risk was 1.4 and odds ratio was 4.7.

CLINICAL RELEVANCE
Performing C-sections in sedated goats may improve kid survival rates over those under general anesthesia.
Retrospective analysis describes safety of therapeutic joint injections in dogs
Authors: Miller Allison V. , Carney Patrick C. , Markmann Alexandra , Frye Christopher W. 
Published: January 2023

Abstract

OBJECTIVE
To retrospectively investigate the safety of canine therapeutic IA injections, describing and correlating adverse events with the number of injections per visit, joint injected, signalment, body condition score, type, and volume of injectate.

SAMPLE
There were 505 joint injections across 283 visits for 178 client-owned dogs, including the shoulder, elbow, carpus, hip, stifle, tarsus, and metacarpophalangeal.

PROCEDURES
A search was performed of the Cornell University Hospital for Animals medical records for relevant data, identifying dogs treated with therapeutic joint injections and rechecked between 2010 and 2022.

RESULTS
Minor complications were noted in 70 of 283 visits and included transient soreness (18.4%, lasting a median of 2 days; range, 1 to 20 days) and gastroenteritis (6.8%). One case of septic arthritis (1/505 joints), which possessed risks of a hematogenous source, was the only potential major complication. Soreness was not correlated with the number of joints injected per visit. Larger volumes of injectate normalized to body size were more likely to be associated with transient soreness in the stifle and tarsus. Across injectates, only stem cells had significantly increased odds of soreness. Gastroenteritis was not associated with the type of injectate.

CLINICAL RELEVANCE
Therapeutic joint injections in dogs are safe, with an extremely low risk of major adverse effects. Transient soreness is a commonly expected minor adverse event. The use of stem cells or larger injectate volumes (confined to the stifle and smaller distal joints) may be more likely to invoke discomfort.