bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biologics for asthma have risk of anaphylactic reactions and serious? : A pharmacovigilance study based on a global real-world database
Authors: Park Sunny , Kim Yeju , Lee Geon Ho , Choi Soo An 
Published: April 2023

Abstract
Asthma is a chronic inflammatory condition that affects the lung airways. Chronic use of oral glucocorticoids in patients with severe asthma is associated with several adverse events (AEs). Biologics (omalizumab, benralizumab, mepolizumab, reslizumab, and dupilumab) have been developed as alternative therapies for the treatment of asthma. The aim of this study was to evaluate the risk of anaphylactic reactions associated with these five biologics based on a large global database. We utilized individual case reports from the Uppsala Monitoring Center from 1968 to December 29, 2019. A disproportionality analysis of all drugs and monoclonal antibodies. Anaphylactic reactions were defined according to the "anaphylactic reaction” of the standardized MedDRA queries. Contrary to dupilumab, omalizumab, benralizumab, and mepolizumab demonstrated positive signals related to anaphylactic reactions among all drugs and monoclonal antibodies. Reslizumab, which represented only 315 cases of all AEs, required more reports to determine its association with anaphylactic reactions. This was an important study since the majority (96.2%) of the cases of anaphylactic reactions were reported serious. In conclusion, the results indicate that omalizumab, benralizumab, and mepolizumab are associated with a high risk of anaphylactic reactions, and careful monitoring in the post-injection period is recommended.
Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp → π*Ar interaction
Authors: Wehn Paul M. , Yang Song , Grina Jonas A. , Rizzi James P. , Schlachter Stephen T. , Wang Bin , Xu Rui , Yang Hanbiao , Du Xinlin , Han Guangzhou , Wang Keshi , Czerwinski Robert M. , Ged Emily L. , Huang Heli , Halfmann Megan M. , Maddie Melissa A. , Morton Emily R. , Olive Sarah R. , Tan Huiling , Xie Shanhai , Josey John A. , Wallace Eli M. 
Published: April 2023

Abstract
Pharmacokinetic properties of our first-generation HIF-2α antagonist PT2385, including modest solubility, resulted in a high recommended phase 2 dose (RP2D) of 800 mg BID and motivated the pursuit of novel scaffolds which could improve solubility and formulation parameters with the goal of improved pharmacokinetics. Herein we disclose our successful efforts to identify such HIF-2α antagonists through an optimization strategy characterized by: (1) increasing the fraction of sp3 hybridized carbons (Fsp3), (2) replacing the aromatic portion of the indane core with pyridine heterocycles, and (3) improving a putative Olp → π*Ar interaction, an underutilized electrostatic contact in medicinal chemistry. These efforts emphasize the importance of employing multiple strategies in parameter optimization. In isolation, modifications to areas (1) and (2) improved solubility, but with the compromise of reduced potency. In area (3), understanding the importance of an Olp → π*Ar interaction, as documented through a wealth of crystal structures and retrospective calculations, proved essential in guiding SAR and identifying the trifluoromethyl group as a suitable replacement of the sulfone. Only by combining these three strategies could inhibitors with substantially improved solubility and comparable potency be discovered. Finally, the overall improvement in pharmacokinetic properties of the newly identified inhibitors is highlighted through a battery of ADME and in vivo data, including use of pharmacodynamic biomarkers indicative of HIF-2α antagonism.
Urinary retention after gynecologic surgeries for benign diseases in Egyptian women
Authors: Elsaid Mahmoud Atef , Gabriel Mohamed Mohamed Ibrahim , Abdelmoaty Muhamed Ahmed , Elsalhy Mohamed Abd-elrahim 
Published: April 2023

Abstract
Background: Postoperative urinary retention (POUR) is the inability to void following surgery. It is a common complication of gynecologic surgery, particularly when urine incontinence and pelvic organ prolapse are treated.
Objective: To determine the incidence and factors influencing urinary retention following benign gynecologic surgery in Egyptian women.
Patients and methods: This research was done on a total of 100 patients who all had gynecologic surgeries for benign diseases within the period from November 2021 to November 2022 in Al-Hussein University Hospital.
Results: the void volume was significantly lower 24 hours postoperative than preoperative and one-week postoperative (P <0.001). The post-void residuals volume was significantly higher 24 hours postoperative than preoperative and one-week postoperative (P < 0.001). 13 of the 100 women included in the study had retention. There were statistically non-significant differences between the presence of POUR and demographic data (P > 0.05). There were statistical significance differences in both POUR and CS presence (P = 0.045) and need for indwelling catheter (P < 0.001). The void volume was considerably lesser before 24 hours postoperative in the patients with retention than the patients without retention (P < 0.001). The post-void residuals substantially greater 24 hours postoperative in the patients with retention than the patients without retention (P < 0.001).
Conclusion: The findings of this study suggest that benign gynecologic surgery may have an unanticipated impact on postoperative voiding dysfunction.
Optimal degrees of freedom of the lower extremities for human walking and running
Authors: Kudo Shoma , Fujimoto Masahiro , Sato Takahiko , Nagano Akinori 
Published: April 2023

Abstract
Determining the degrees of freedom (DOF) of the linked rigid-body model, representing a multi-body motion of the human lower extremity, is one of the most important procedures in locomotion analysis. However, a trade-off exists between the quality of data fitting and the generalizability of the model. This study aimed to determine the optimal DOF of the model for the lower extremities that balance the goodness-of-fit and generalizability of the model during walking and running using Akaike’s information criterion (AIC). Empirically obtained kinematic data for the lower extremities during walking and running were fitted by models with 9, 18, or 22 DOF. The relative quality of these models was assessed using their bias-corrected AIC (cAIC) value. A significant simple main effect of the model was found on the cAIC value for both walking and running conditions. Pairwise comparisons revealed that the cAIC value of the 18-DOF model was significantly smaller than that of the 9-DOF (walking: p< 0.001, running: p = 0.010) and 22-DOF (walking: p < 0.001, running: p < 0.001) models. These findings suggest that the 18-DOF model is optimal for representing the lower extremities during walking and running, in terms of goodness-of-fit and generalizability.
Diagnostic significance and utility of circulating redox biomarkers in patients with gastric cancer
Authors: Dorf Justyna , Pryczynicz Anna , Matowicka-Karna Joanna , Kędra Bogusław , Żukowski Piotr , Zalewska Anna , Maciejczyk Mateusz 
Published: April 2023

Abstract

The aim of our study was to evaluate the redox status, antioxidant barrier as well oxidative damages in gastric cancer patients. We are also the first to assess the diagnostic utility of redox parameters in GC patients in respect to histopathological parameters. 50 patients with gastric cancer and 50 healthy controls matched for sex and age were included in the study. Antioxidant barrier, redox status and oxidative damage products were measured in serum/plasma samples using colorimetric or spectrophotometric method. The activity of SOD (p < 0.05) was significantly higher whereas the activity of CAT (p < 0.0001), GPx (p < 0.0001), GR (p < 0.0001) and GSH (p < 0.05) was considerably lower in GC patients compared to the control group. Levels of TOS (p < 0.0001), OSI (p < 0.0001), AOPP (p < 0.0001), IMA (p < 0.01), LOOH (p < 0.0001), 8-Iso-P (p < 0.0001) and DNA/RNA (p < 0.0001) were significantly higher, and the levels of TAC (p < 0.0001) and total thiols (p < 0.0001) were considerably lower in GC patients compared to the healthy control. Some redox parameters are characterised by high AUC value in differentiation GC patients according to histopathological parameters. Gastric cancer is strongly linked to systemic redox imbalance as well as increased oxidative damage to proteins, lipids and DNA. Redox biomarkers can be potential diagnostic indicators of gastric cancer advancement.
Wheat varietal diversity affects arbuscular mycorrhizal symbiosis and soil enzymatic activities in the root zone
Authors: Taschen Elisa , Guillot Esther , Dezette Damien , Abadie Josiane , Arnal Didier , Plassard Claude , Taudière Adrien , Enjalbert Jérôme , Roux Xavier Le , Hinsinger Philippe 
Published: April 2023

Abstract
High-input agriculture has been associated with a drastic reduction of within-field crop genetic diversity, while plant (mostly functional) diversity in natural ecosystems has been shown to promote ecosystem functioning. Increasing intra-specific diversity in agroecosystems is a promising strategy to stabilize crop productivity and promote the associated diversity of fauna and microbiota. We investigated the effect of the within-field diversity of bread wheat varieties on arbuscular mycorrhizal fungi (AMF) and two enzymatic activities involved in organic nitrogen and phosphorus mineralization. A field experiment was designed to test whether the number of mixed wheat varieties in a plot, or their functional diversity (previously assessed), influence the abundance and diversity of AMF and the activity of leucine aminopeptidases and phosphatases in the root zone. The AMF abundance was measured by quantitative polymerase chain reaction, community composition was analyzed by Illumina metabarcoding on two AMF specific markers, and potential microbial activities were quantified by biochemical assays. Wheat traits related to root morphology and susceptibility to fungal diseases previously quantified for each variety were also used. Number of varieties significantly increased AMF abundance in roots, whereas functional cluster number did not, with no impact of root morphology. Functional cluster number influenced AMF diversity, though weakly and not linearly, responding most to binary mixtures. Both wheat variety and functional group number increased the potential leucine amino-peptidase activities in the root zone, while no effect was observed for phosphatase activities. Our results highlight that increasing crop intra-specific diversity triggered changes in key processes involved in nutrient acquisition.
From static state to dynamic simulation: a delivery-path-oriented approach to quantify ecosystem services and its application to ecological management
Authors: Su Dan , Wu Qing , Fang Xiaoqian , Cao Yu , CAO Yu 
Published: April 2023

Abstract
As the researches on Ecosystem Services (ESs) become more systematic and mature, concerns on ESs flow have been raising because of its high value in aid ecological management and improvement of human welfare. Despite that the importance of ESs flow have been emphasized, they are mostly semantic, lacking the empirical operation of ESs quantification. Based on the reality observation and literatures extraction, we think the ESs flow can be assessed from direction characteristics, and three classic ESs, crop provision, water yield, and carbon sequestration were chosen as the cases. Combined with their delivery mediums of road work, river runoff, and atmosphere, they are distinguished and classified as three major flow directions, i.e., specific path, single path, and omni-direction. Moreover, the revised two-step floating catchment area method are employed to quantify the ESs flow size, for which has the basic information of supply-side, demand-side, flow direction and distance. The results show (1) the mismatch between supply and demand varies with different ESs and areas. (2) The characteristics of direction, path, services extent, and delivery size of ESs flows are depicted with their own unique attributes. (3) The final ecological status of different areas is changed by integrating the ESs flow into supply and demand, which shows the necessity of ESs flow consideration rather than just supply-demand pattern. This study complements the researches on ESs, generalizes the approach to quantify ESs flow, provides a comprehensive assessment on supply-demand relationship, and offers more scientific and reasonable references to city planning and ecological strategies.
A High-Gain Dual-Band Shared-Aperture Array Integrating Zero-Order-Resonance Patch and Higher-Order Metasurface Antenna
Authors: Chen Qian , Cheng You-Feng , Shao Chen-Hao , Feng Ju , Liao Cheng , Xiao Ding 
Published: April 2023

Abstract
This letter proposes a high-gain shared-aperture array which integrates the hybrid zeroth-order-resonance (ZOR) patch and the higher-order metasurface antenna (MA). In terms of each array element, four hybrid ZOR patches with shorting pins form a metasurface which is fed by slot coupling. Different from some reported designs which have more high-frequency elements than low-frequency ones, the whole array is composed of 4 × 4 hybrid ZOR patches operating in C band (4.74 ∼ 5.12 GHz) and 2 × 2 MAs working in Ku band (13.0 ∼ 14.0 GHz). Such a layout brings that the designed array has the benefit to reduce Ku-band loss. Measure results validate the dual-band operation and show that the antenna has its peak gains of 12.7 dBi and 17.2 dBi in these two bands, respectively.
Feedback of sports intelligent learning system based on model predictive control and artificial intelligence
Authors: Liu Yunzhao , Liu Li 
Published: April 2023

Abstract
The numerical solution of the sports intelligent learning system has high complexity during operation, which restricts the online application of optimal control. In order to improve the optimization effect of the feedback delay of the sports intelligent learning system, this paper discusses the method of efficiently solving the optimal control problem of the differential-algebraic system from the aspects of improving the efficiency of the integration process and selecting an appropriate constraint processing strategy. Moreover, this paper proposes an efficient calculation method for solving the index-1 DAE optimal control problem under continuous inequality constraints. This method avoids a large number of interior point constraints introduced by discretization of continuous inequality constraints and makes it possible to solve optimal control problems under continuous inequality constraints. In addition, this paper designs a one-step advanced model predictive control algorithm to solve the NLP problem one sampling period in advance, and then correct the solution of the NLP problem through sensitivity analysis. Finally, this paper designs experiments to study the performance of the method proposed in this paper. The research results show that the method constructed in this paper is effective.
Application of Multi-sensor Network and Artificial Intelligence in Health Monitoring of Medical Geriatric Care
Authors: Meng Hua , Han Yi , Zan Zhi 
Published: April 2023

Abstract
The comprehensive use of data from multiple sensors for moving target tracking is a long-term problem in multi-sensor data fusion. In wireless sensor networks, state estimation and fusion are the main research issues in target tracking. Distributed is the essential feature of wireless sensor networks. Therefore, with the development of wireless sensor networks, the problem of distributed state estimation has also attracted the attention of scholars. The intelligent medical diagnosis system is composed of a traditional Chinese medicine diagnosis system, a western medicine diagnosis system, and a medical record database. The TCM diagnostic system and the Western medicine diagnostic system are the main body of the system. The TCM diagnostic system is based on a case-based reasoning model, using human body information collection equipment to simulate the process of TCM diagnostics and realize TCM diagnostic engineering, while the Western medicine diagnostic system is a neural network optimized based on genetic algorithms. Model, obtain the diagnosis and treatment method of the disease from the medical record database of the hospital information system. The basic standards for nursing homes issued by the Ministry of Health have promoted the standardized development of nursing homes. However, since the development of China's elderly care homes is still in its infancy, it makes the service content and functional positioning of elderly care homes, and orderly connection with relevant medical institutions and elderly care institutions, The main body of institutional management and the formulation of supporting policies are still in the exploratory stage. Among the chronically ill population, the proportion of elderly people ranks first. At the same time, due to the particularity of the elderly population, the recovery time is lengthened. Due to various reasons, they cannot get adequate medical services in the hospital. Due to the impact of diseases, the health of the elderly is not optimistic, and even loses their lives. Therefore, the daily immediate monitoring of the elderly is very necessary.
Do cancer centres and palliative care wards routinely measure patients’ quality of life? A cross-sectional survey study
Authors: Miranda Rose , Raemdonck Eveline , Deliens Luc , Kaasa Stein , Zimmermann Camilla , Rodin Gary , Robijn Lenzo , Lundeby Tonje , Houbracken Isabelle , Beernaert Kim 
Published: April 2023

Abstract

Purpose: Routinely assessing quality of life (QoL) of patients with cancer is crucial for improving patient-centred cancer care. However, little is known about whether or how cancer centres assess QoL for clinical practice or for research purposes. Therefore, our study aimed to investigate if QoL data is collected and if so, how and for what purposes.
Method: We conducted a cross-sectional survey study among 32 cancer centres in Europe and Canada. Centre representatives identified the most suitable persons within their cancer ward and/or palliative care ward to complete an online survey. Descriptive statistics were used to summarise the information on QoL assessment and documentation.
Results: There were 20 (62.5%) responding cancer centres. In total, 30 questionnaires were completed, of which 13 were completed for cancer wards and 17 for PC wards. We found that 23.1% and 38.5% of the cancer wards routinely assessed QoL among inpatients and outpatients with cancer, respectively, whereas, in palliative care wards, 53% assessed QoL for outpatients with cancer and 70.6% for the inpatients. Wide variabilities were observed between the cancer centres in how, how often, when and which instruments they used to assess QoL.
Conclusion: A sizable proportion of the cancer wards, especially, and PC wards apparently does not routinely assess patients’ QoL, and we found wide variabilities between the cancer centres in how they do it. To promote routine assessment of patients’ QoL, we proposed several actions, such as addressing barriers to implementing patient-reported outcome measures through innovative e-Health platforms.
An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats
Authors: Beyrami Sona , niri Hasan Hadadzadeh , Golmohammadi heidar , Panahi Mohammad Hossein , Abbaszadeh Hojjat Allah , mahmoudi saeed , Fazlzadeh Mehdi , Gharari Noradin 
Published: April 2023

Abstract

Background: Occupational and environmental exposures to organic solvents and noises in the workplace are major health issues. One of these solvents is toluene, and on top of that noise is an impartible part of any industry. the present study aims to determine the alteration of oxidative stress parameters and the histopathological changes caused by simultaneous exposure to toluene and noise in the brain tissue.
Methods: For this purpose, 32 male Wistar rats were divided into four experimental groups and then were exposed to varying factors for 8 hours a day (8 h/day) for 28 days. These four groups were: 1) The control group, 2) The group exposed to noise (100dB), 3) The group exposed to toluene by inhalation (500 ppm), and 4) The group simultaneously exposed to both of them. In this study, the levels of lipid peroxidation (MDA) and glutathione (GSH) and the histopathological changes of the brain tissue were determined.
Results:The findings suggest that, in the various parts of the temporal brain tissue simultaneously exposed to toluene and noise, the cohesion was more decreased compared to the tissues in other groups. Furthermore, in the group simultaneously exposed to both factors the MDA level increased and the GSH level decreased significantly.
Conclusions: The results indicated the impact of synergistic interaction between noise and toluene on the accumulation of oxidation products, the progressive morphological damages as well as the weakening of the antioxidant defense system in brain tissues of rats and being simultaneously exposed to both factors has a cumulative effect
Post-Malaria Neurological Syndrome (PMNS): a rare case report with brain biopsy findings
Authors: Alawad Mouhammad J , Almayoof Moustafa , bozom Adel Al , Alkhidir Taha , Emam Saeed S , Farfar Khalifa 
Published: April 2023

Abstract
Post-malaria neurological syndrome (PMNS) is a rare, self-limiting condition that presents with a wide range of neurological manifestations after clearance of malarial infection, especially Plasmodium Falciparum, most patients recover without residual deficits. Here we present a case of a 29-year-old, male with a recent history of malaria treated successfully, who presented due to a generalized tonic-clonic seizure, without any other neurological symptoms, the examination and labs were unremarkable, he underwent a computer tomography (CT) scan and Magnetic resonant imaging (MRI) which both showed two areas of vasogenic edema involving the subcortical white matter of left frontal and right posterior parasagittal regions, all autoimmune screens, infection workup from blood and CSF were negative, he underwent a brain biopsy that showed intense perivascular inflammation with neuronal loss and gliosis, findings are nonspecific and can be seen in a variety of condition. The patient’s condition improved, and he was discharged without any complications.
New MCDM Applications using Cubic Bipolar Fuzzy Model in Medical and Engineering
Authors: Farooq Adeel , Nabeel Muhammad , Ali Ghous 
Published: April 2023

Abstract
Nowadays, several fuzzy extensions of ELECTRE (Elimination and Selection Transforming Reality) and TOPSIS (The Order Preference by Similarity to Positive Ideal Solution) methods are emerging as powerful mathematical tools for dealing with uncertainties in different multi-criteria decision-making (MCDM) situations of medical and engineering domains. Since cubic bipolar fuzzy (CBF) set theory is also becoming an effective mathematical tool for such kinds of problems. In this study, we present an improved CBF-TOPSIS method using the concepts of normalized Euclidean distance and revised closeness index because in the existing CBF-TOPSIS method the notions of Euclidean distance and relative closeness index were used to reach the final decision. Then, we rectify the shortcomings of the existing CBF-ELECTRE-I method, that is, there was a problem in the discordance formula. To modify the existing algorithm based on the CBF-ELECTRE-I model, we add a new step to find the exact linear ranking order of alternatives, which is purely based on concordance and discordance outranking coefficients. Second, we explore two new applications to validate the applicability and feasibility of the improved CBF-ELECTRE-I and CBF-TOPSIS methods in medical and engineering. Finally, to demonstrate the veracity of the modified CBF-ELECTRE-I and CBF-TOPSIS methods, we perform a brief sensitivity analysis between them and other existing models.