bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tension, War, Peace, and Unification: South Korea’s Unification Policies in the Light of Theological-Ethical Theories of War and Peace
Authors: Lee Chang-Ho 
Published: May 2023

Abstract
This article analyzes South Korea’s unification policies and makes ethical suggestions in light of Christian theological and ethical theories of war and peace. Since 1948, South and North Korea have repeatedly confronted each other with heavily armed forces. Unification would be considered the achievement of the Korean people’s endeavour to deter military warfare and promote peace between the two Koreas. In this regard, it is understandable that unification policy-making should retain tension reduction and peaceful coexistence as its fundamental goals. Public discussions in unification policy-making inevitably involve such issues as prohibition or justification of the use of violence or military force and procedures and methods of promoting peace. In analyzing unification policies in Christian ethical terms, such Christian war-peace tenets as pacifism, just war, and holy war contribute to this analysis, given that their primary concerns lie in maintaining peace and justifying violence for the sake of peace.
Protestant Theological Perspectives on the Contribution of Military Chaplains to Moral Formation
Authors: Oosterhuis Thijs , Vos Pieter , Olsman Erik 
Published: May 2023

Abstract
Military chaplains are involved in the moral formation of military personnel. They have to do justice to the internal perspective on morality of their religion, while honouring the plurality of perspectives. The objective of this article is to examine how the contribution of military chaplains to the moral formation of military personnel can be substantiated from a Protestant theological perspective. We first discuss Tillich’s Protestant principle, which functions as a starting point and criterion in the moral discourse. We then show how Bonhoeffer combines a view of reality inspired by faith and a serviceable attitude towards reality. Finally, we focus on the role of theology and the role of the military chaplain as theologian in the moral formation of military personnel with the ideas of Volf and Croasmun. We conclude that Protestant theological perspectives on morality are vital to the moral formation of military personnel.
Colour–Touch Cross-Modal Correspondence and Its Impact on Single-Modal Judgement in Multimodal Perception
Authors: Yuan Tianyi , Rau Pei-Luen Patrick , Zhao Jingyu , Zheng Jian 
Published: May 2023

Abstract
This study explored the colour–touch cross-modal correspondence and its impact on colour–touch multisensory perception. Two laboratory experiments were conducted based on a pre-experiment. In the first experiment, participants chose the colour according to their tactile sense against the vibration generated by the smartphone simulator. A positive cross-modal correspondence was obtained between the vibration amplitude and the colour chroma, indicating the existence of a colour–touch correspondence. The correspondence between vibration parameters and colour hue was preliminarily explored. The impact of the correspondence on the multisensory senses was investigated in the second experiment. Different stimulus combinations were played on a smartphone. The participants were asked to choose the perceived stimulus level. The data illustrated that a better correspondence improved judgement accuracy and reduced reactiontime. Overall, this study offers evidence for colour–touch cross-modal correspondence and presents its potential influence on the single-modal judgement in multimodal perception. The results can be applied in further cross-modal studies, assisting barrier-free society construction and multimodal interface design.
The Cultural and Economic Diplomacy of an Emerging Trade Power: the European Community at the Osaka Expo, 1970
Authors: Nose Kazuhiro 
Published: May 2023

Abstract
This article examines the European Community’s participation in the Osaka Expo in 1970 from the standpoint of whether it was an exercise in cultural diplomacy or an economic exercise. While there was at the time a growing European consciousness and common identity, this article shows that while the ec’s intention in participating in the Osaka Expo may have been to foster its cultural mandate, in reality it was motivated more by economic concerns. It makes a significant contribution to the literature because the ec’s participation in the Expo in 1970 has been largely neglected, even forgotten, and is worth revisiting as a case study of cultural and economic diplomacy as practiced by an organization in an arena in which nation-states usually participated.
Activism and Research: Reflections from the Classroom and Critical Pedagogy
Authors: Bek Mine Gencel 
Published: May 2023

Abstract
This text discusses the relationship between academic research and activism by expanding the debate to teaching. Firstly, the literature on the connection between academia and research will be reviewed with a focus on gender studies. Afterwards, the results of the small-scaled research which was conducted with undergraduate and postgraduate students on activism and research in 2022 will be summarized.
Parallel Arbitral Proceedings: An Analysis of the Issue of Parallel Arbitrations in International Commercial Arbitration within the European Legal Space
Authors: Kalantzi Anastasia 
Published: May 2023

Abstract
Avoiding lis pendens within the EU has always been considered a guarantee for effective judicial cooperation. However, since arbitration is excluded from the scope of European procedural law, questions have been raised as to how parallel arbitral and state court procedures will be regulated. This article aims to illustrate the mechanisms that have been proposed to resolve this issue outside the European Regulations’ scheme with a focus on parallel arbitrations. Under this scope, the author attempts to discuss the potential solutions that have been introduced in respect to “lis pendens” between an arbitral tribunal and a state court as well as their effectiveness. Taken the tie from this analysis, the last part of this article focuses on the issue of parallel arbitral procedures and whether conflicts of jurisdiction can be resolved by using the same mechanisms as adopted in the case of parallel the arbitral and state court proceedings.
The Applicability of the Brussels I bis Regulation to Hybrid Dispute Resolution Clauses
Authors: Okyay N. Kansu 
Published: May 2023

Abstract
The hybrid clause is an optional dispute resolution clause that offers the parties to a contract, for resolving their dispute, an option between state courts and arbitral tribunals. The combination of two different dispute resolution mechanisms, litigation and arbitration, raises the issue of determining the international or regional instruments applicable to this clause, such as Brussels I bis Regulation. As a matter of fact, the Recast of Brussels I Regulation, in line with its predecessors, excludes arbitration from its material scope. Since the hybrid clause contains an option to arbitrate, this exclusion raises the question of the applicability of the Regulation to this form of optional dispute resolution clause.
Enforcing an icsid Award Issued in an Intra-EU Investment Arbitration: An Italian Law Perspective
Authors: Sorace Francesco 
Published: May 2023

Abstract
As a consequence of the cjeu’s decisions in Achmea, Komstroy, and pl Holdings, the enforcement of intra-EU investment awards has now become subject to serious challenges based on EU law. At the same time, the enforcement system under the icsid Convention is designed to prevent challenges at the enforcement stage. The article analyzes the potential clash between contrasting obligations under EU law and international law from the perspective of Italian law. To this end, it draws from the experience of other EU courts in the context of the Micula saga as well as from the only available example of enforcement of an icsid award in Italy. The article considers the various possible approaches to the intra-EU issue and then examines the compatibility of the icsid enforcement system with the Italian Constitution.
A Normative Model of Conventionality Control
Authors: Negishi Yota 
Published: May 2023

Abstract
I am honored to be invited to this symposium featuring on my recent book and to receive comments from two distinguished experts, Sabrina Ragone and Jorge Contesse; for this I sincerely thank Editors-in-Chief, in particular Giuseppe Martinico, for convening this fantastic symposium. Taking this opportunity, I would like to illustrate the whole picture of this project for readers. The first section identifies the research problem and explains about the main topic, namely, the doctrine of conventionality control (1). Next, the second section provides a summary of the contents of each chapter (2). Finally, the third section presents the most original contribution of this book, that is, the trapezium model of the relationship between international and domestic law (3).
Insurance Status, Comorbidity Diagnosis, and Hepatitis C Diagnosis Among Antibody-Positive Patients: A Retrospective Cohort Study
Authors: Goodman Sara H. , Zahn Matthew , Boden-Albala Bernadette , Lakon Cynthia M. 
Published: May 2023

Background In California, laboratories report all hepatitis C (HCV)-positive antibody tests to the state; however, that does not accurately reflect active infection among those patients without a viral load test confirming a patient's HCV diagnosis. These public health surveillance disease incident records do not include patient details such as comorbidities or insurance status found in electronic medical records (EMRs). Objective This research seeks to understand how insurance type, insurance status, patient comorbidities, and other sociodemographic factors related to HCV diagnosis as defined by a positive viral load test among HCV antibody-positive persons from January 1, 2010 to March 1, 2020. Methods HCV antibody-positive individuals reported to the California Reportable Disease Information Exchange (CalREDIE), with a medical record number associated with the University of California, Irvine Medical Center, and an unrestricted EMR (n = 521) were extracted using manual chart review. Main Outcomes and measures HCV diagnosis as indicated in a patient's EMR in the problem list or disease registry. Results Less than a quarter of patients in this sample were diagnosed as having HCV in their EMR, with 0.4% of those diagnosed (5/116) patients with indicated HCV treatment in the medication field of their charts. After adjusting for multiple comorbidities, a multinomial logistic regression found that the relative risk ratios (RRRs) of HCV diagnosis found that patients with insurance were more likely to be diagnosed compared to those without insurance. When comparing uninsured patients to those with government insurance at the P < .05 level (RRR = 10.61 (95% confidence interval (CI): 4.14-27.22)) and those uninsured to private insurance (RRR = 6.79 (95% CI: 2.31-19.92). Conclusions These low frequencies of HCV diagnosis among the study population, particularly among the uninsured, indicate a need for increased viral load testing and linkage to care. Reflex testing on existing samples and improving HCV screening and diagnosis can help increase linkage to care and work towards eliminating this disease.
High karyotypic complexity is an independent prognostic factor in patients with CLL treated with venetoclax combinations
Authors: Fürstenau Moritz , Thus Yvonne J. , Robrecht Sandra , Mellink Clemens H. M. , van der Kevie-Kersemaekers Anne-Marie , Dubois Julie , von Tresckow Julia , Patz Michaela , Gregor Michael , Thornton Patrick , Staber Philipp B. , Tadmor Tamar , Levin Mark-David , da Cunha-Bang Caspar , Schneider Christof , Poulsen Christian Bjoern , Illmer Thomas , Schöttker Björn , Janssens Ann , Christiansen Ilse , Nösslinger Thomas , Baumann Michael , Hebart Holger , Gaska Tobias , Regelink Josien C. , Dompeling Ellen C. , Lindström Vesa , Juliusson Gunnar , Widmer Anouk , Goede Jeroen , Goldschmidt Neta , Simon Florian , De Silva Nisha , Fink Anna-Maria , Fischer Kirsten , Wendtner Clemens-Martin , Ritgen Matthias , Brüggemann Monika , Tausch Eugen , Spaargaren Marcel , Eldering Eric , Stilgenbauer Stephan , Niemann Carsten U. , Hallek Michael , Eichhorst Barbara , Kreuzer Karl-Anton , Kater Arnon P. 
Published: May 2023

Abstract
Complex karyotypes have been associated with inferior outcomes in chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy (CIT), whereas their prognostic impact in the context of venetoclax-based treatments is still debated. In this prospective analysis on karyotype complexity in CLL, we evaluated the impact of complex (≥3 chromosomal aberrations [CAs], CKTs) and highly complex karyotypes (≥5 CAs; hCKTs) as well as specific aberrations in previously untreated patients without TP53 aberrations undergoing either CIT or time-limited venetoclax-based therapies in the phase 3 GAIA/CLL13 trial. Karyotype analyses were available for 895 of 926 patients (96.7%), of whom 153 (17%) had a CKT and 43 (5%) hCKT. In the CIT arm, CKT was associated with shorter progression-free survival (PFS) (hazard ratio [HR] 2.58; 95% confidence interval [95% CI], 1.54-4.32; P &lt; .001) and overall survival (HR, 3.25; 95% CI, 1.03-10.26; P = .044). In the pooled venetoclax arms, a multivariable analysis identified hCKTs (HR, 1.96; 95% CI, 1.03-3.72; P = .041), but not CKTs, as independent adverse prognosticators for PFS. The presence of translocations (unbalanced and/or balanced) was also independently associated with shorter PFSs in the venetoclax arms. CIT led to the acquisition of additional CAs (mean CAs, 2.0-3.4; from baseline to CLL progression), whereas karyotype complexity remained stable after venetoclax-based treatments (2.0, both time points). This analysis establishes highly complex karyotypes and translocations as adverse prognostic factors in the context of venetoclax-based combination treatments. The findings of this study support the incorporation of karyotyping into the standard diagnostic workup of CLL, because it identifies patients at high risk of poor treatment outcomes and thereby improves prognostication. This trial was registered at www.clinicaltrials.gov as #NCT02950051.
Nonnegative matrix factorization analysis and multiple machine learning methods identified IL17C and ACOXL as novel diagnostic biomarkers for atherosclerosis
Authors: Rao Li , Peng Bo , Li Tao 
Published: May 2023

Abstract
Background
Atherosclerosis is the common pathological basis for many cardiovascular and cerebrovascular diseases. The purpose of this study is to identify the diagnostic biomarkers related to atherosclerosis through machine learning algorithm.

Methods
Clinicopathological parameters and transcriptomics data were obtained from 4 datasets (GSE21545, GSE20129, GSE43292, GSE100927). A nonnegative matrix factorization algorithm was used to classify arteriosclerosis patients in GSE21545 dataset. Then, we identified prognosis-related differentially expressed genes (DEGs) between the subtypes. Multiple machine learning methods to detect pivotal markers. Discrimination, calibration and clinical usefulness of the predicting model were assessed using area under curve, calibration plot and decision curve analysis respectively. The expression level of the feature genes was validated in GSE20129, GSE43292, GSE100927.

Results
2 molecular subtypes of atherosclerosis was identified, and 223 prognosis-related DEGs between the 2 subtypes were identified. These genes are not only related to epithelial cell proliferation, mitochondrial dysfunction, but also to immune related pathways. Least absolute shrinkage and selection operator, random forest, support vector machine- recursive feature elimination show that IL17C and ACOXL were identified as diagnostic markers of atherosclerosis. The prediction model displayed good discrimination and good calibration. Decision curve analysis showed that this model was clinically useful. Moreover, IL17C and ACOXL were verified in other 3 GEO datasets, and also have good predictive performance.

Conclusion
IL17C and ACOXL were diagnostic genes of atherosclerosis and associated with higher incidence of ischemic events.
A statistical approach for identifying primary substrates of ZSWIM8-mediated microRNA degradation in small-RNA sequencing data
Authors: Wang Peter Y. , Bartel David P. 
Published: May 2023

AbstractBackgroundOne strategy for identifying targets of a regulatory factor is to perturb the factor and use high-throughput RNA sequencing to examine the consequences. However, distinguishing direct targets from secondary effects and experimental noise can be challenging when confounding signal is present in the background at varying levels.ResultsHere, we present a statistical modeling strategy to identify microRNAs that are primary substrates of target-directed miRNA degradation (TDMD) mediated by ZSWIM8. This method uses a bi-beta-uniform mixture (BBUM) model to separate primary from background signal components, leveraging the expectation that primary signal is restricted to upregulation and not downregulation upon loss of ZSWIM8. The BBUM model strategy retained the apparent sensitivity and specificity of the previous ad hoc approach but was more robust against outliers, achieved a more consistent stringency, and could be performed using a single cutoff of false discovery rate (FDR).ConclusionsWe developed the BBUM model, a robust statistical modeling strategy to account for background secondary signal in differential expression data. It performed well for identifying primary substrates of TDMD and should be useful for other applications in which the primary regulatory targets are only upregulated or only downregulated. The BBUM model, FDR-correction algorithm, and significance-testing methods are available as an R package athttps://github.com/wyppeter/bbum.
Comprehensive meta-QTL analysis for dissecting the genetic architecture of stripe rust resistance in bread wheat
Authors: Kumar Sandeep , Saini Dinesh Kumar , Jan Farkhandah , Jan Sofora , Tahir Mohd , Djalovic Ivica , Latkovic Dragana , Khan Mohd Anwar , Kumar Sundeep , Vikas V. K. , Kumar Upendra , Kumar Sundip , Dhaka Narendra Singh , Dhankher Om Parkash , Rustgi Sachin , Mir Reyazul Rouf 
Published: May 2023

AbstractBackgroundYellow or stripe rust, caused by the fungusPuccinia striiformis f. sp.tritici (Pst) is an important disease of wheat that threatens wheat production. Since developing resistant cultivars offers a viable solution for disease management, it is essential to understand the genetic basis of stripe rust resistance. In recent years, meta-QTL analysis of identified QTLs has gained popularity as a way to dissect the genetic architecture underpinning quantitative traits, including disease resistance.ResultsSystematic meta-QTL analysis involving 505 QTLs from 101 linkage-based interval mapping studies was conducted for stripe rust resistance in wheat. For this purpose, publicly available high-quality genetic maps were used to create a consensus linkage map involving 138,574 markers. This map was used to project the QTLs and conduct meta-QTL analysis. A total of 67 important meta-QTLs (MQTLs) were identified which were refined to 29 high-confidence MQTLs. The confidence interval (CI) of MQTLs ranged from 0 to 11.68 cM with a mean of 1.97 cM. The mean physical CI of MQTLs was 24.01 Mb, ranging from 0.0749 to 216.23 Mb per MQTL. As many as 44 MQTLs colocalized with marker–trait associations or SNP peaks associated with stripe rust resistance in wheat. Some MQTLs also included the following major genes-Yr5,Yr7,Yr16,Yr26,Yr30,Yr43,Yr44,Yr64,YrCH52, andYrH52. Candidate gene mining in high-confidence MQTLs identified 1,562 gene models. Examining these gene models for differential expressions yielded 123 differentially expressed genes, including the 59 most promising CGs. We also studied how these genes were expressed in wheat tissues at different phases of development.ConclusionThe most promising MQTLs identified in this study may facilitate marker-assisted breeding for stripe rust resistance in wheat. Information on markers flanking the MQTLs can be utilized in genomic selection models to increase the prediction accuracy for stripe rust resistance. The candidate genes identified can also be utilized for enhancing the wheat resistance against stripe rust after in vivo confirmation/validation using one or more of the following methods: gene cloning, reverse genetic methods, and omics approaches.
Novel soil-less potting mixes for the mycorrhization of Quercus pubescens Willd. seedlings with Tuber melanosporum Vittad.
Authors: Pagliarani Sofia , Vannini Andrea , Kuzminsky Elena , Morales-Rodríguez Carmen 
Published: May 2023

AbstractTruffle cultivation has quickly grown in Europe and elsewhere as a consequence of the increase in the demand of the market. Thus the optimization of the protocols for the production of elite mycorrhized plants are also needed, keeping in consideration the economic and environmental sustainability. The suitability of two compost-based potting mixes to produceQuercus pubescensWilld. plants mycorrhized with the black Périgord truffleT. melanosporumVittad. was tested as an alternative to the traditional potting mix used. The effects on mycorrhizal development and the morphometric assessment of the root and shoot system of theQ. pubescensseedlings were investigated eight months after the spore slurry inoculation in a glasshouse experiment. From the results obtained, the compost mix containing green organic residues from pruning and mowing (Mix 2) achieved better performance than the control and the potting mix based on composted municipal organic wastes, showing significantly higher mycorrhization percentage, root length, number of root tips, and root forks. In conclusion, a potting mix containing recycled green organic matter, which is readily available, cheap, and environmentally sustainable, can offer excellent mycorrhization performances and may be included in the mycorrhization process of downy oak seedlings withT. melanosporumunder controlled conditions.