bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with the status of usual source of care during the COVID-19 pandemic: a nationwide survey in Japan
Authors: Aoki Takuya , Matsushima Masato 
Published: July 2023

Abstract
Background. To ensure that high-quality primary care is available to every individual, increasing the proportion of residents with a usual source of care (USC) is a challenge for each country. However, the status of USC after the spread of COVID-19 and the factors associated with it remain unclear internationally. Therefore, we aimed to explore the associations of sociodemographic and clinical factors with the presence and type of USC (kakaritsukeiin Japanese) during the pandemic in Japan.
Methods. We conducted a nationwide cross-sectional survey of a representative sample of the general Japanese adult population in May 2021. The main outcome measures were the presence and type of USC. We assessed sociodemographic and clinical factors, including age, gender, marital status, years of education, employment status, annual household income, social isolation, health literacy, number of chronic conditions, and health-related quality of life.
Results. Of the 1,757 participants, 1,011 (57.5%) had a USC. There were 769 (76.1%) participants who had a USC in a clinic and 227 (22.5%) in a hospital. As a result of multivariable modified Poisson regression analysis, male gender, no chronic condition, lower health literacy, and social isolation were significantly associated with not having a USC. Among participants with a USC, male gender, the presence of one or more chronic conditions, and lower health-related quality of life were associated with having a hospital-based USC.
Conclusions. We identified factors associated with the status of USC during the COVID-19 pandemic, including health literacy and social isolation. These findings provide primary care providers and policymakers with insight into the potential facilitators and barriers to having a USC in the aftermath of the pandemic.
There is market potential for circular farming food in Europe due to consumers’ willingness to purchase and pay a premium for circular-labeled food
Authors: Li Shanshan , Kallas Zein , Ornelas Selene , Pereira Edilene , Behrendt Lena , Hajdu Zoltán , Michels Evi , Meers Erik 
Published: July 2023

Abstract
Circular farming, as a sustainable agricultural system, contributes to the reuse of waste and optimizes the recovery of nutrients (C, N, P). By circular farming we refer to farming activities that focus on using minimal amounts of external inputs, closing nutrient loops, and minimizing environmental impacts. Here we employed open-ended choice experiments (OECEs) to analyze consumers’ willingness to pay (WTP) and demand for food products obtained from circular farming with a questionnaire involving 5,591 participants from 6 EU countries. We chose three product categories: pork, milk, and bread. We found that a market niche existed for the food products produced from circular farming, with consumers exhibiting a willingness to pay a premium for circular products compared to conventional products. Spanish consumers displayed the highest WTP premium (>26%), whereas Hungarian consumers exhibited the lowest in all categories. Socio-demographic characteristics, environmental attitudes, and price levels influenced the quantity of circular products consumers are willing to purchase.
Rice Husk Ash as a Sustainable and Economical Alternative to Chemical Additives for Enhanced Rheology in Drilling Fluids
Authors: RAZA ALI , hussain Maham , raza Nadeem , aleem Waqas , AHMED SHERAZ , qamar sabih 
Published: July 2023

Abstract
Performance evaluation of drilling fluids is eminent for a successful drilling project as they not only remove drill cuttings but also prevent undesired penetration or outflow of formation fluids by sealing off wellbore walls. However, concerns have been raised about the use of chemical additives in drilling fluids due to their toxicity and non-biodegradability. To this end, agricultural waste materials are recognized as a promising alternative as they are cost-effective, environmentally sustainable, and can be used as a substitute for lost circulation materials. Rice husk ash (RHA) has become popular as an additive due to its renewable characteristics including large surface area, silica content, and microporous structure. This research article explores the rheological properties of drilling fluid with RHA as a filter control medium. The results showed that increasing concentrations of RHA in the drilling mud significantly improved its rheology particularly at higher concentrations (15 and 20 wt.%). The addition of RHA modified the filtration and rheological properties of the drilling mud resulting in improved plastic viscosity, yield point, density, gel strength, and thixotropy. However, the filter loss and mud cake thickness increased at elevated RHA concentration. Furthermore, the pH test revealed that the mud's properties shifted towards the acidic region as the RHA concentration increased. The results indicate that RHA could be used as a sustainable and cost-effective alternative to conventional chemical additives with a positive environmental impact. This study may also provide valuable insights into the use of RHA in water-based bentonite mud and could serve as a guide for future research in the drilling industry.
Emergence of modern-style continental subduction modulated by rifted margin-subduction feedback
Authors: Ganade Carlos , Riel Nicolas , Manatschal Gianreto , Tesser Lucas , Rubatto Daniela , Hermann Joerg , Weinberg Roberto , Lanari Pierre , Kaus Boris 
Published: July 2023

Abstract
Modern-style continental subduction is the main carrier of rifted margins to mantle depths (> 90 km) where ultra-high pressure (UHP) metamorphism above coesite stability is attained[1,2]. An open question is why exhumed UHP rocks, a key feature of modern-style continental orogens, only appeared and became common late in Earth’s history. The long-standing explanation relies on the higher geothermal gradient of the ancient Earth, which would either prevent continental subduction to reach UHP conditions or prevent their exhumation[3,4]. Although different exhumation mechanisms for UHP rocks have been discussed[5], none of them integrate the recent paradigm shifts in understanding the architecture and lithology of rifted continental margins[7]. Here, we perform high-resolution thermomechanical numerical experiments to demonstrate that segments of magma-poor rifted margins that reach UHP conditions can exhume back to shallower levels, while segments of magma-rich rifted margins cannot. This is because the thick layer of basaltic rocks in magma-rich margins becomes negatively buoyant during metamorphism, preventing their exhumation. We further argue that the secular decrease in both mantle potential temperature and fertility would have favoured the formation of magma-rich rifted margins in the first half of Earth’s history, affecting the recycling and exhumation of deep subducted margins. The record shows that the conditions for development of magma-poor rifted margins may have become achievable during the Earth’s middle age (1.5-0.8 Ga), when cold and more refractory, depleted mantle limited melting and therefore magmatism. When these magma-poor rifted margins reached collision zones in the Neoproterozoic, their positive buoyancy forced the exhumation of the oldest unequivocally coesite-bearing UHP rocks at 0.6 Ga[8,9]. Since then, UHP rocks have become a key and ubiquitous feature of modern-style continental orogens.
Study on application and environmental effect of phosphogypsum - fly ash - red mud composite cemented paste backfill
Authors: Pan Zude , Pan Rongxiang , Cao Yang , Chen Qianlin , Yang Min 
Published: July 2023

AbstractPhosphogypsum (PG) cementitious paste backfill (CPB) was prepared by using PG and Fly ash (FA) as the main raw materials, Red mud (RM) as the alkaline activator, Portland cement (OPC) as the binder, and silica fume (SF) as the additive, and its properties were investigated to achieve the objective of "treating harm with waste". The results showed that the addition of OPC facilitated the flowability of the slurry, while the addition of RM and SF had the opposite effect. The slurry presented ideal flowability when the water/binder ratio was 0.2 and the superplasticizer (SP) content was 0.7%. The mechanical properties and water resistance was improved significantly with increasing OPC, RM, and SF doping. The strength of the CPB material exceeded 22 MPa after curing at room temperature for 28 d, which met the mine filling requirements. Changes in the ion concentrations of the solution were first monitored during immersion. The dissolution rules of Ca2+and SO42−at different immersion ages confirmed that RM promoted the continuous hydration of CPB, which was the key to improving water resistance. Microstructural analysis showed that the main hydration products were AFt and C-S-H, which played an important role in the strength development of the material. The leaching results demonstrated that the metal ion content satisfied the requirements of the Ⅲ categories of Chinese environmental standards (GB/T 14848 − 2017), indicating that the technology is a reliable and environmentally friendly technology for PG, FA, and RM recovery that can simultaneously support safe mining.
Factors influencing physicians’ decision to conduct cardiovascular risk assessments among cancer patients: A Systematic Review
Authors: Teh Hoon Shien , Subramaniam Shridevi , Thiagarajan Muthukkumaran , Hwong Wen Yea 
Published: July 2023

Abstract

Background
Improved cancer survivorship has led to untoward effects of developing cardiovascular complications, mainly due to exposure to cardiotoxic cancer therapy. Cardiovascular screening can provide substantial benefits to patient care and outcomes, but successful implementation is challenging. This systematic review consolidates factors from existing literature and explores its relationships to highlight key domains that need to be addressed to implement these risk assessment programs in clinical practice.
Methods
We searched PubMed, EMBASE, CINAHL, Web of Science and PsycINFO using search terms focused specifically on factors influencing the implementation of cardiovascular risk assessment among the cancer population. Two reviewers completed independently in study selection, data extraction, and quality assessment. To get meaningful insight of the findings, we thematically matched those factors into the domain of the Tailored Implementation for Chronic Diseases (TICD) framework and inductively identified its relationships.
Results
Twelve studies met the inclusion criteria. Identified factors were grouped into six domains, of which the top three included factors related to individual health professionals, which were cited in 83% of studies, incentives and resources (75% of the studies), and professional interactions in 58% of studies. Within the domain of individual health professional, we include factors concerning cognitions and attitudes, knowledge and skills, and professional behaviour. The domain of incentives and resources highlighted the needs for availability of necessary resources, continuing education system, assistance for clinicians and financial-related issues. Communication influence, team and referral processes were found to be the main barriers in the domain of professional interaction. Bi-directional associations were evident between these domains, which were categorised into macro and micro levels for better interpretation.
Conclusion
This review identified key factors that could be leveraged to improve cardiovascular assessment reach and appeal. Future intervention efforts should first be targeted at the level of healthcare professionals, who are the key drivers of the entire process.
Multiple Hopf bifurcations of four coupled van der Pol oscillators with delay
Authors: Liu Liqin , Zhang Chunrui 
Published: July 2023

Abstract
In this paper, a system of four coupled van der Pol oscillators with delay is studied. Firstly, the conditions for the existence of multi-periodic solutions of the system are given. Secondly, the multi-periodic solutions of spatiotemporal patterns of the system are obtained by using symmetric bifurcation theory. The normal form of the system on the central manifold and the direction of the bifurcation periodic solution are given. Finally, numerical simulations are used to support our theoretical results.
MSC: 34K18, 35B32
Evaluating the Shear Stiffness of Asymmetric Angle-Ply Layers in Diagonal Cross-laminated Timber
Authors: kurzinski Shaghayegh , Crovella Paul 
Published: July 2023

Abstract

The perpendicular orientation of the cross-layer (s) makes Cross-laminated Timber (CLT) susceptible to rolling shear failure and reduced stiffness in bending. Under out-of-plane bending, rolling shear failure occurs in the cross layers along the radial-tangential plane. This weakness in CLT panels could be improved by varying the grain orientation of the cross-layers away from perpendicular-to-grain (90°), and closer to parallel-to-grain (0°). This paper studies the shear stiffness of a pair of asymmetric angle-ply layers rotated at angles from 90° to 70°, 40°, 20°, 10°, and 0°. These two layers with varying grain orientations were assumed to be representative of the inner layers of a four-ply Diagonal Cross-laminated Timber (DCLT) panel. For this purpose, Hankinson’s formula was applied in addition to two-plate shear tests and numerical modeling. The experimental testing and FE model results were compared with the theoretical values to evaluate the theory for shear stiffness prediction of the asymmetric angle-ply layers. The results of the three methods showed an agreement in predicting an increase in shear stiffness when the angle-ply orientation of the layers decreases from 90° to 0°. The results indicated that Hankinson’s formula seems to be a conservative theoretical predictor for the shear stiffness of diagonal layers. Regarding the experimental results, orienting the cross layers to an angle between 70° and 40° was shown to improve the rolling shear stiffness by 10% and 46% respectively. This research provides insights into innovations towards CLT development with improved rolling shear stiffness using diagonally-oriented layers.
Governing digital innovations for responsible outcomes – the case of digital healthcare and welfare services
Authors: Thapa Raj Kumar , Iakovleva Tatiana 
Published: July 2023

AbstractDigital innovations integrated with Responsible innovation (RI) offer great potential to address complex societal challenges in the healthcare and welfare sector but depend on how well firms can manage the innovation process to ensure socially desirable solutions. However, there is a lack of empirical studies examining whether RI principles can be integrated into a firm’s innovation development process. This paper aims to fill this gap through longitudinal case studies of six digital start-ups in the healthcare and welfare sector from 2016 to 2019. We followed innovation development in these firms, observing the stakeholder inclusion, pivotal moments and the emergence of new solutions based on the need-solution interactions. We found that stakeholder inclusion is critical. Therefore, we suggest that managers and entrepreneurs consider including a diversity of stakeholders and users from the design phase throughout the innovation process.
A comparison of in vitro drug exposure modes: submerged versus ALI in the Vitrocell ® Cloud 24 aerosol exposure system
Authors: Steiner Sandro , Morelli Moran , Ferreira Sandra , Fischli Maica , Merg Celine , Titz Bjorn , Kondylis Athanasios , Xiang Yang , Sewer Alain , Toorn Marco , Hoeng Julia 
Published: July 2023

Abstract
In medical applications, inhalable drugs are commonly delivered as aerosols in which the drug is i) the only bioactive constituent and ii) confined to the particulate fraction. For these low complexity aerosols, there are indications that in vitro exposure at the air-liquid interface (ALI) does not increase in vitro-in vivo translatability compared to the less complex and more controlled exposures under submerged conditions. We characterized aerosol delivery within the Vitrocell® Cloud 24 an in vitro aerosol exposure system frequently used for conducting ALI exposures—and used the system to test the hypothesis that there are no relevant differences between exposure modes. Cultures of the human adenocarcinoma-derived cell line A549 were exposed to bortezomib, anatabine, or the selective IκB kinase IKK-16, either in submerged state or at the ALI. The drugs’ toxicities and efficacies to counteract an induced pre-inflammatory state were compared between the exposure modes. The impact of the complexity of the biological test system was investigated by including ALI exposures of organotypic bronchial epithelial cultures. Our results demonstrate that i) the Vitrocell® Cloud 24 is useful for conducting controlled aerosol exposures and ii) ALI and submerged exposures are not equivalent.
Depletion of two-level systems in highly stable glasses with different molecular ordering
Authors: Moratalla Manuel , Rodríguez-López Marta , Rodriguez-Tinoco Cristian , Rodriguez-Viejo Javier , Jimenez-Rioboo Rafael , Ramos Miguel 
Published: July 2023

Abstract
Recent findings of structural glasses with extremely high kinetic and thermodynamic stability have attracted much attention. The question has been raised as to whether the well-known, low-temperature “glassy anomalies” (attributed to the presence of two-level systems [TLS] and the “boson peak”) persist or not in these ultrastable glasses of much lower configurational entropy. To resolve previous contradictory results, a particular type of ultrastable glass has been studied, TPD, which can be prepared by physical vapor deposition in a highly-stable state with different degrees of layering and molecular orientation, and also as a conventional glass and in crystalline state. After a thorough characterization of the different samples prepared, their specific heat was measured down to 0.4 K. Whereas the conventional glass exhibited the typical glassy behavior and the crystal the expected Debye cubic dependence at very low temperatures, a strong depletion of the TLS contribution was found in both kinds of ultrastable glass, regardless of their layering and molecular ordering.
Impact of preoperative docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy on degree of malignant esophageal stenosis
Authors: Yamaguchi Takahisa , Okamoto Koichi , Saito Hiroto , Shimada Mari , Tsuij Toshikatsu , Moriyama Hideki , Kinoshita Jun , Nakamura Keishi , Inaki Noriyuki 
Published: July 2023

Abstract
Background:
Malignant esophageal stenosis is a common and severe complication of advanced esophageal cancer that can be a serious problem in the continuation of chemotherapy and other anticancer treatments. The impact of chemotherapy regimens on the degree of improvement in esophageal stenosis is unknown. In this study, we focused on the impacts of chemotherapy on the direct anticancer effects, and in the improvement of malignant stenosis.
Methods:
Patients who underwent radical esophagectomy after chemotherapy, either adjuvant 5-fluorouracil and cisplatin (FP) or docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen, were included. We assessed the length of the cancerous stenosis, the width of the narrowest segment, and the size of the intraluminal area in the stenotic segment, and compared the differences before and after chemotherapy. The antitumor effects of chemotherapy were also investigated.
Results:
A total of 81 patients were enrolled: 50 were treated with FP, and 31 were treated with DCF. The expansion rate in the length of the narrowest part was significantly increased in the DCF group compared with the FP group. Furthermore, the stenosis index (intraluminal stenotic area/stenotic length) was significantly increased in the DCF group compared with the FP group (112% vs 96%, P=0.038). The response rates were 60% in the FP group and 67.7% in the DCF group. Effective histopathological response (improvement to grade 2 or 3) was 24% in the FP group and 38.8% in the DCF group.
Conclusion:
DCF therapy is more effective than FP treatment in the improvement of malignant esophageal stenosis.
Optimizing the hydrolysis-acidification stage in municipal wastewater treatment: comparison of immobilized fillers and granular sludge
Authors: Liu Xuyan , Yang Hong , Yang Kai 
Published: July 2023

Abstract
The decomposition of organic macromolecules in sewage is currently greatly aided by hydrolysis-acidification. The full use of its qualities can help domestic sewage biodegrade more quickly, promoting the subsequent aerobic reactions. This study evaluated the hydrolysis-acidification performance of granular sludge and filler in residential sewage. Both forms had a high VFA production capacity at the beginning of the reaction, but the granular sludge gradually disintegrated over time, especially at low temperatures, which decreased its performance. High-throughput sequencing revealed that the filler included a greater quantity of hydrolytic-acidifying bacteria than the granular sludge, with a higher performance.
Predicting Trajectories of Vocational Indecision from Motivational Profiles in Early Adolescence
Authors: Mbanga Remy , Ratelle Catherine , Duchesne Stéphane 
Published: July 2023

Abstract

Background and objective
During emerging adulthood, vocational indecision (i.e., the inability to make coherent career choices) develops in a heterogeneous fashion, with three distinct patterns: low; decreasing (i.e., developmental or adaptative); high and stable or increasing (i.e., chronic, or maladaptive). Among the determinants of vocational indecision that have been identified in past research, academic motivation is an excellent choice, since it is at school that students' vocational choices are validated or not. So, the purpose of this longitudinal study was to verify if the patterns found with emerging adulthood students characterized vocational indecision in adolescent students, and if so, to predict the belonging to the most problematic trajectory by using students’ academic motivational profiles. Academic motivation was assessed using self-determination theory.
Method and Results
Using data from 384 students (56% female) surveyed annually from Secondary 2 to 5, person-centered analyses allowed to estimate motivational profile in Secondary 2 and vocational indecision trajectories during the 4-year period. Results revealed four distinct patterns of vocational indecision during adolescence labelled Low and Stable, Moderate and Stable, Developmental and Chronic Intermittent. Four motivational profiles were also identified in Secondary 2, ranging from poor (Highly Amotivated) to moderate (Autonomous-Introjected) quality of self-determination level. Also, in reference to the most self-determined profile, students in the Mixed profile were at greatest risk of following Chronically-Intermittently Undecided trajectory. Finally, the most self-determined students were at greatest probability of following the Developmentally Undecided trajectory.
Conclusion
Overall, the findings suggest that the student motivational functioning in early secondary school years could be used to identify students at risk of experiencing the negative indecision patterns across secondary school. Several theoretical and practical implications are suggested.