bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel thiosemicarbazone and thiazolidin‐4‐one derivatives containing vanillin core: Synthesis, characterization, and anticancer activity studies
Authors: Tokalı Feyzi Sinan , Şenol Halil , Katmerlikaya Tuğba Gençoğlu , Dağ Aydan , Şendil Kıvılcım 
Published: January 2023

AbstractCancer is one of the most common and lethal disease in the world, therefore, patients need new and potent anticancer agents for treatment. In this study, starting from vanillin, 24 new compounds, which are 12 thiosemicarbazone (4a‐h, 5i‐j, 6k) and 12 thiazolidin‐4‐one (7a‐h, 8i‐j and 9k) derivatives, were synthesized and characterized by Nuclear Magnetic Resonance (NMR), High‐Resolution Mass Spectroscopy (HRMS), and Fourier‐transform Infrared (FTIR) techniques. In vitro cytotoxic effects were investigated on CCD‐1079Sk human healthy fibroblast and MDA‐MB‐231 human breast cancer cell lines. For MDA‐MB‐231, molecules showed IC50 in ranging of 88.08 ± 0.027–16.54 ± 0.031 μM (Doxorubicin: 61.70 ± 0.021 μM) and for CCD‐1079Sk, molecules showed IC50 in ranging of 192.36 ± 0.018–13.58 ± 0.035 μM (Doxorubicin:52.01 ± 0.028 μM). Compounds 6k and 7f were found most selective and potent anticancer agents compared to Doxorubicin used as a standard drug.
Evaluation of sodium‐glucose cotransporter 2 inhibitors for renal prognosis and mortality in diabetes patients with heart failure on diuretics
Authors: Weng Yi‐Fang , Chen Chung‐Yu , Hwang Shang‐Jyh , Huang Yaw‐Bin 
Published: January 2023

AbstractPrevious studies about renal protection of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in type 2 diabetes mellitus (T2DM) patients with heart failure (HF) on diuretics were still limited. The goal of the study is to survey the efficacy of SGLT2i to reduce all‐cause mortality and renal impairments in patients with T2DM and HF using diuretics. The retrospective cohort study was analyzed from Kaohsiung Medical University Hospital Research Database (KMUHRD) in Taiwan. Adults with T2DM and HF using any diuretics at least 28 days during 2016–2018 were enrolled and then divided into the SGLT2i group and the non‐SGLT2i group. Propensity score matching was used to balance baseline characteristics between the two groups. The primary outcome was all‐cause mortality. Secondary outcomes contained dialysis occurrence, renal progression, and acute kidney injury (AKI). After 1:1 matching, there were 183 patients in each group respectively. When compared with the non‐SGLT2i group, the SGLT2i group had significantly lower all‐cause mortality (hazard ratios [HR]: 0.49, 95% CI 0.29–0.83, p = 0.008) and reduction of renal progression (HR: 0.30, 95% CI 0.12–0.75, p = 0.010). SGLT2i showed the trend to decrease dialysis occurrence (HR: 0.83, 95% CI 0.20–3.47, p = 0.797) and an increase in AKI (HR: 1.38, 95% CI 0.67–2.87, p = 0.383) but without significance. SGLT2 inhibitors were associated with reduced all‐cause mortality and less renal progression with significance in T2DM patients with HF on diuretics.
Deep Neuromuscular Block for Endolaryngeal Surgery: A Systematic Review and Meta‐Analysis
Authors: Zheng Jianqiao , Du Li , Zhang Lu , Du Bin , Zhang Weiyi , Chen Guo 
Published: January 2023

ObjectivesTo determine the safety and efficacy of deep neuromuscular block (NMB) for endolaryngeal surgery.Data SourcesPubMed, Web of Science, Cochrane Library, Ovid Medline, Embase, China National Knowledge Infrastructure, Wanfang, VIP databases, and trial registry database.MethodsInclusion criteria followed the PICOS principles: Participants, adults undergoing endolaryngeal surgery; Intervention, deep NMB performed during the surgery; Control, no‐deep NMB performed; Outcomes, primary outcome: the incidence of clinically acceptable surgical conditions. Secondary outcome: the incidence of intraoperative complications (including vocal fold movement and coughing) and total incidence of postoperative complications [including postoperative residual curarization (PORC), postoperative sore throat (POST), and postoperative nausea and vomiting (PONV)]. Study design, randomized controlled trials (RCTs). Duplicate publications, editorials, letters, abstracts, and reviews were excluded.ResultsFour articles with 242 patients were identified for analysis. The results indicated that compared with no‐deep NMB, deep NMB provides a higher incidence of clinically acceptable surgical conditions (98.36% vs. 76.67%; relative ratio [RR] = 1.29, 95% CI: 1.07–1.56), a lower incidence of intraoperative complications (10.83% versus 37.16%; RR = 0.32; 95% CI: 0.21–0.49) (lower incidence of vocal fold movement [1.85% vs. 34%; RR = 0.08, 95% CI: 0.02–0.41] and coughing [15.53% vs. 38.78%; RR = 0.42, 95% CI: 0.27–0.66]). There were no differences in the overall incidence of postoperative complications (RR = 2.10, 95% CI: 0.12–36.40).ConclusionsBased on current published evidence, deep NMB provides better surgical conditions with a higher incidence of clinically acceptable surgical conditions and a lower incidence of intraoperative complications (lower incidence of vocal fold movement and coughing) without increasing the overall incidence of postoperative complications.Level of Evidence1 Laryngoscope, 133:2055–2065, 2023
Land degradation in the European Union—Where does the evidence converge?
Authors: Gianoli Federico , Weynants Mélanie , Cherlet Michael 
Published: January 2023

AbstractLand degradation, as a compound of processes that affect land resources worldwide, is notoriously difficult to assess. In Europe, the European Commission has been pressed by the Court of Auditors (ECA) to invest in better understanding land degradation and desertification within the European Union. In the World Atlas of Desertification (WAD), the convergence of evidence (CoE) has been put forward as an integration mechanism to help focus attention on areas where human‐induced global land change issues (LCIs) are putting pressure on the planetary boundaries, potentially leading to land degradation. Rather than trying to map degradation itself, the CoE explores how many of these processes are simultaneously at play and where they occur. In this study, we tailor the CoE framework to the European Union through a more appropriate selection of regionally relevant LCIs and a focus on finer input data. Our analysis draws attention to areas in Europe confronted with specific environmental challenges (e.g., the Po Valley or the Ruhr region) and confirms that LCIs mostly accumulate in croplands and urban areas. We found that more LCIs consistently coincide with a specific Sustainable Development Goal indicator (SDG indicator 15.3.1, calculated using the Trends.Earth tool), signals a degrading status. However, our analysis also shows that many areas with a stable or improving status are subject to LCIs not considered in that indicator. We therefore advise including other indicators of land status and trends when assessing land degradation, while stressing that the link to contextual knowledge remains necessary for a final interpretation.
Sarkisov links for index 1 Fano 3‐folds in codimension 4
Authors: Campo Livia 
Published: January 2023

AbstractWe classify Sarkisov links from index 1 Fano 3‐folds anticanonically embedded in codimension 4 that start from so‐called Type I Tom centres. We apply this to compute the Picard rank of many such Fano 3‐folds.
Optimal timing of needle electromyography to diagnose lesion severity in traumatic radial nerve injury
Authors: Steenbeek Esli D. , Pondaag Willem , Tannemaat Martijn R. , Van Zwet Erik W. , Malessy Martijn J. A. , Groen Justus L. 
Published: January 2023

AbstractIntroduction/AimsIn patients with traumatic radial nerve injury (RNI), the chance of spontaneous recovery must be balanced against the benefits of early surgical reconstruction. We aimed to explore the time‐specific value of needle electromyography (NEMG) to diagnose nerve lesion severity.MethodsIn this retrospective diagnostic accuracy study at Leiden Nerve Center, patients at least 12 years of age with RNI caused by fractures or fracture treatment were included. The sensitivity and specificity of the patients' first NEMG examination were assessed, stratified by the timing after the nerve injury. The absence of motor unit potentials (MUPs) in muscles distal to the nerve lesion was considered a positive test result. Lesion severity was dichotomized to moderate injury (spontaneous Medical Research Council grade ≥3 recovery) or severe injury (poor spontaneous recovery or surgical confirmation of a mainly neurotmetic lesion).ResultsNinety‐five patients were included in our study. The sensitivity of NEMG to detect severe RNI was 75.0% (3 of 4) in the fourth, 66.7% (2 of 3) in the fifth, and 66.7% (2 of 3) in the sixth month after the nerve injury. The specificity in the first to the sixth month was 0.0% (0 of 1), 50.0% (2 of 4), 77.3% (17 of 22), 95.5% (21 of 22), 95.8% (23 of 24), and 100.0% (12 of 12), respectively.DiscussionThe specificity of NEMG is higher than 95% and therefore clinically relevant from the fourth month after the nerve injury onward. Absence of MUPs at this time can be considered an indication to plan nerve exploration. Moreover, the presence of MUPs on NEMG does not completely exclude the necessity for surgical reconstruction.
Modeling melt conveying and power consumption of co‐rotating twin‐screw extruder kneading blocks: Part B. Prediction models
Authors: Stritzinger Ursula , Roland Wolfgang , Berger‐Weber Gerald , Steinbichler Georg 
Published: January 2023

AbstractIntermeshing co‐rotating twin‐screw extruders are very versatile because their screw configurations can be tailored both to the application and to the properties of the materials used. Finding the best screw configuration is one of the main purposes of twin‐screw extrusion modeling, and requires models that accurately predict conveying and power consumption. The better the process can be predicted, the better the requirements of the final product can be met. We present novel prediction models of the conveying and power‐consumption behaviors of intermeshing co‐rotating twin‐screw extruder kneading blocks for Newtonian fluids. These are based on numerical simulations and therefore consider the complex three dimensional (3D) geometry of this element type without the need for common simplifications. Our models are thus capable of including all leakage flows and gap influences, which are usually ignored, for example, by the flat‐plate model. Since our models are derived by symbolic regression based on genetic programming, they consist of algebraic functions and are low‐threshold. They can be used to calculate various process parameters for individual kneading blocks or entire screw configurations, as illustrated by a use case.
Analysis and improvement of hot work management in China
Authors: Wang Xin 
Published: January 2023

AbstractHot work, work involving electric or gas welding, cutting, brazing, or similar flame or spark‐producing operations, is a major industrial hazard. Many countries have formulated relevant regulations and standards for hot work to regulate their management procedures and operational requirements. This article compares and analyses the safety‐related regulations and standards for hot work in China and the United States. The article puts forward relevant suggestions for the revision and improvement of China's hot work regulations and standards in comparison with the US regulations and standards. In terms of details, the US regulations and standards are more scientific, stringent, and guiding. China's standards are more closely related to China's national conditions, but some provisions lack scientific basis and are poorly operable. Further enhancement of the scientific, guidance, and operationality of China's hot work‐related regulations and standards is recommended.
A fatigue reliability assessment approach for wind turbine blades based on continuous time Bayesian network and FEA
Authors: Liu Zheng , He Zhenfeng , Tu Liang , Liu Xin , Liu Haodong , Liang Jinlong 
Published: January 2023

AbstractWind turbine blades made by composite materials (CWTBs), encounter fatigue failures, such as cracks, fractures, delamination, etc. Finite Element Analysis (FEA) is applied for fatigue performance simulations of CWTBs as the full‐scale testing is costly. To consider correlated failures and uncertainties in load and material parameters, this paper proposes a fatigue reliability assessment method based on continuous time Bayesian network and FEA. Specifically, the dangerous regions of each component of CWTBs are determined by finite element fatigue simulation. The failure probability distributions of components are then computed by quantifying the uncertainties of several factors including the load and material parameters. A continuous time Bayesian network model is constructed for the fatigue reliability of CWTBs. The performance of the proposed method is verified by a comprehensive analysis with the results of discrete time Bayesian networks.
Adaptive sliding mode control of Markov jump systems with completely unknown mode information
Authors: Jiang Baoping , Karimi Hamid Reza , Li Bo 
Published: January 2023

AbstractThis paper aims to investigate the problem of adaptive sliding mode control for Markov jump systems with deficient transition probability. Different from the existing literature, we propose a novel method to design a mode‐dependent sliding mode controller when the mode information is completely unknown, while the controller gain parameters can be designed by solving feasible conditions. Firstly, by designing an integral‐type sliding surface, on which an ideal sliding mode dynamics is obtained. Then, for different types of mode transition information, a set of feasible easy‐checking stochastic stability criteria are proposed for the sliding mode dynamics in terms of strict linear matrix inequalities. Further, relying on the parameters obtained from the stability criteria, an adaptive sliding mode controller is successfully designed with respect to different types of system mode transition information. Finally, a numerical example is provided to illustrate the advantage of the developed strategy.
Bioactivity and Catalytic Reduction of Aryl Nitro‐Compounds by Biosynthesized Silver Nanoparticles using Skimmiaanquetilia
Authors: Gondwal Manjul , Sharma Nidhi , Joshi nee Pant Geeta , Pratap Singh Gautam Bhanu , Singh Sangeeta , Tumba Kaniki , Bahadur Indra 
Published: January 2023

AbstractThe green synthesis of silver nanoparticles is a rapid and environmentally friendly technique (AgNPs). Silver ions are bioreduced into AgNPs by a compound found in Skimmiaanquetilia's aqueous leaf extract, which consists primarily of alkaloids and coumarins. AgNPs were synthesized and characterized by multiple techniques, including ultraviolet‐visible spectroscopy, Fourier transform infrared analysis, scanning electron microscopy with X‐ray energy dispersive (EDX) investigation, transmission electron microscopy (TEM), and X‐ray diffraction (XRD). The results demonstrated that the AgNPs are highly effective in inhibiting the growth of Escherichia coli. The scavenging activity and hemolysis (2.85 %) of the AgNPs of S. anquetilia leaf extract were also observed and found that the catalyst was useful in the catalytic reduction of aromatic nitro compounds to aromatic amines. NaBH4 was used to catalyse the reduction of nitro compounds by a UV‐Visible spectrophotometer, and the reduction rates of compounds like 4‐nitrophenol, 2‐nitrophenol, 4‐nitroaniline, 2‐nitroaniline, 4‐nitrobenzaldehyde, 2‐nitrobenzaldehyde, 4‐chloronitrobenzene, and 3‐chloronitrobenzene were measured. AgNPs produced from S. anquetilia leaf extract were found to be an effective catalyst for the reduction reaction and to possess potent antibacterial properties. In higher concentrations, AgNPs were found to have greater antioxidant potential than plant extracts.
Acid Autocatalysis Best Served Hot: The Chlorate–Sulfite–Gluconolactone System as a Thermochemical Clock
Authors: Kürsteiner Ronny , Panzarasa Guido 
Published: January 2023

AbstractThe autonomous activation of acid‐autocatalyzed sulfite–halogenate (iodate, bromate, chlorate) reactions is programmed using slow acid generators (δ‐gluconolactone GL, and 1,3‐propanesultone PrS). A remarkable correlation is found between the pH‐ and temperature‐time profiles, especially for the chlorate–sulfite–GL system. Further optimization of the latter resulted in a chemical system able to generate sudden temperature and pH changes after a tailorable induction time, that is a “thermochemical clock”.
The effect of reducing dietary lipid and food availability on precocious male maturation in Chinook Salmon: A production-scale hatchery experiment
Authors: Harstad Deborah L. , Larsen Donald A. , Clarke Lance , Spangenberg Dina K. , Hogg Robert , Requa Brett , Beckman Brian R. 
Published: January 2023

Abstract

Objective
Age of maturation in Chinook Salmon Oncorhynchus tshawytscha is phenotypically plastic, influenced by both genotype and environmental factors, including the availability and composition of the diet. Salmon hatchery programs often rear fish under accelerated growth regimes using high-lipid diets that can result in earlier age at maturity, including increased prevalence of age-2 males (minijacks). The goal of this investigation was to compare alternative dietary regimes to mitigate for this shift in age at maturity in hatchery-reared Umatilla River fall Chinook Salmon.

Methods
Juvenile fish were reared at Bonneville Hatchery, Oregon, under four dietary treatments across four replicate brood years. Dietary treatments included two feeding frequencies (standard [fed 7 days/week] and reduced [fed 4 days/week]) and two dietary lipid levels (standard [18%] and reduced [12%]) in a 2 × 2 factorial design. Dietary treatments were applied for approximately 9 months, beginning in March (a month after fry emergence) and lasting until December of the first year, after which all fish were reared on the standard feeding regime (7 days–18%) until the time of release the following spring as yearlings.

Result
We observed significant interannual variation in the proportion of minijacks produced among dietary treatments. For all brood years, decreasing the feeding frequency from 7 to 4 days/week reduced the proportion minijacks by 35.9%, and lowering dietary lipid from 18% to 12% reduced the proportion minijacks by 30%. The combined effects of reducing the feeding frequency and lowering dietary lipid were additive, reducing the proportion minijacks by 65.5% compared to the standard rearing regime. Growth and energetic indices were monitored throughout and confirmed findings from previous laboratory-based studies indicating that physiological status 10–12 months prior to spawn timing is important for the “decision” to mature.

Conclusion
Results of this investigation provide useful insights for optimizing rearing regimes for the Umatilla River program and other Chinook Salmon hatchery programs.
Sea-Cliff Interferometry: Dover Heights, 1946
Authors: Goss W. M. , Hooker Claire , Ekers Ronald D. 
Published: January 2023

AbstractBy mid-November 1945, Pawsey had begun planning for an observational programme in the post-54RS era. Although Pawsey was clearly appreciative of the excellent cooperation of the RAAF at Collaroy, the radio group at RPL now needed a site closer to the Laboratory at Sydney University, with accessible and convenient public transport. In addition, RPL needed a field station site under their own control, allowing modifications on the equipment to be made by their staff. The obvious solution was to start work at the Dover Heights ShD (Shore Defence) or C.D. (Coastal Defence) station of the Australian Military Forces. This station had been used by RPL during WWII for radar development and was only 10 km from the lab and reachable by public buses. The station was called CA No. 1 (Costal Artillery). As we have seen, Pawsey had begun planning for the first observations (January 1946) the previous November. An image from the WWII era of the Shore Defence aerial at Dover Heights is shown in Fig. 13.1.
Just a Boy from the Bush, 1908–1925
Authors: Goss W. M. , Hooker Claire , Ekers Ronald D. 
Published: January 2023

AbstractOf course Lade Pawsey’s family were enormously keen on education. Writing much later in his life, Joe particularly credited his mother with a single-minded focus on ensuring he had a good education. In this, Margaret Pawsey was typical of many of her generation in highly prizing education, both for its own sake as well as for the opportunities that it could open up, and who were fierce in their defence of it amid other family economic priorities.
Overseas Again: Jodrell Bank and IAU, August 1955
Authors: Goss W. M. , Hooker Claire , Ekers Ronald D. 
Published: January 2023

AbstractThe Pawseys had been hopeful of spending much of 1955 in the USA and Canada. But late in 1954 Lenore’s ill health threatened that plan. Greenstein wrote on 12 January 1955: “I hope your projected visit to the [US in 1955] will come off; and that we will see you.”
Radio Source Survey: Reconciliation, 1958–1962
Authors: Goss W. M. , Hooker Claire , Ekers Ronald D. 
Published: January 2023

AbstractIt was one matter for Hewish and Pawsey to come to a quiet agreement in Illinois—and quite another to achieve a change in view across a scientific community. This community was now more diverse and included astronomers, cosmologists, and newly retrained radio physicists and engineers, with varying predilections, experiences and assumptions about what information about the cosmos was important or reliable.
Conclusion: J.L. Pawsey (1908–1962) and the Development of Radio Astronomy
Authors: Goss W. M. , Hooker Claire , Ekers Ronald D. 
Published: January 2023

AbstractWhat have we learned about Joe Pawsey, and how does a deeper understanding of his life and career provide a deeper understanding of the first 17 years of the field of radio astronomy? Along the way in assembling a detailed record of Pawsey’s life and career, there have been many opportunities to develop an understanding of the complexities of science-in-action. What circumstances, what factors, influenced discoveries being made or missed? What analogies can be drawn between past and present radio astronomy research? What kind of social systems might best promote good science? In what ways do scientists contribute substantially beyond their direct intellectual contributions, for example to national prestige, or economic development, or the public communication of science? These questions have underpinned our analysis, and we return to them here.
The Role of Translational Landslides in the Evolution of Cuesta Topography
Authors: Abe Shinro , Higaki Daisuke , Hayashi Kazunori 
Published: January 2023

AbstractIn recent years, large-scale earthquakes such as the 2004 Mid-Niigata Prefecture Earthquake in Japan and the 1999 Chi-Chi Earthquake in Taiwan have caused rockslides on the back slopes of cuestas. These rockslides in cuestas appear not only in earthquakes but also during rainfalls. This study focuses on the rockslides on cuesta’s back slopes. From field surveys in Japan, Taiwan, Switzerland, and Nepal, we extracted geological, structural, and morphological features common to them. We examined the relationships between these features and triggers, such as pore pressure increases and earthquakes. The majority of landslides initially occur as primary landslides; the forms of these masses then change gradually over a long period. However, our results show that landslides on cuesta’s back slopes slide over and over along the same laminar rock joints and thus hardly change their landscape essence. We demonstrate that rockslides on cuesta’s back slopes play a vital role in the evolution of cuesta landscapes.