bluuebunny/crossref_metadata_2025_split huggingface dataset:
Speicheldrüsenkarzinome – Monozentrische Erfahrung zu Subtypen und deren Inzidenz über 42 Jahre
Authors: Krauss Christian , Wagner Steffen , Klußmann Jens-Peter , Pons-Kühnemann Jörn , Arens Christoph , Langer Christine , Wittekindt Claus 
Published: December 2022

Zusammenfassung
Hintergrund Speicheldrüsenkarzinome sind selten und heterogen. Über 20 Subtypen sind anerkannt und Risikofaktoren sind vielfältig. Ziel dieser Arbeit war die Bewertung des Subtyps und weiterer Risikofaktoren bei einem monozentrischen Kollektiv aus über vier Jahrzehnten.
Material und Methoden 205 Fälle (Diagnosezeitraum 1972–2014) wurden retrospektiv erhoben und hinsichtlich der Verteilung von Risikofaktoren und deren Einfluss auf die Gesamtüberlebenszeit (overall survival, OS) statistisch ausgewertet.
Ergebnisse 19/24 (79,2%) der in der WHO-Klassifikation gelisteten Subtypen kamen in der Kohorte selten vor (< 5%). Davon wurden 10/24 (41,7%) Subtypen nie diagnostiziert. Das Plattenepithelkarzinom (PEC), Adenokarzinom (AdenoCa), Azinuszellkarzinom (AzinusCa), Mukoepidermoidkarzinom (MEC) und adenoidzystische Karzinom (ACC) sind mit zusammen 145/205 (70,7%) die mit Abstand häufigsten Subtypen. Risikofaktoren sind in diesen Gruppen signifikant unterschiedlich vertreten (z.B. lymphogene Metastasierung und Differenzierungsgrad beim AdenoCa und Alter, T- und UICC-Stadium beim PEC). Das 5-Jahres Gesamtüberleben aller Patienten war 66,9% und unterscheidet sich signifikant innerhalb der häufigsten Subtypen. Ein unabhängiger Einfluss auf das Gesamtüberleben war in der multivariaten Analyse feststellbar für das Alter der Patienten (p<0,001), sowie das T- (p=0,003) und N-Stadium (p=0,046).
Schlussfolgerungen Die meisten Subtypen traten auch innerhalb von Jahrzehnten ausgesprochen selten oder gar nicht auf. Die häufigsten Diagnosen unterscheiden sich bezüglich der Risikofaktoren als auch hinsichtlich des OS, so dass 3 Risikogruppen gebildet werden können. Schlussfolgernd ist die Betrachtung von TNM alleine für die Prognoseabschätzung beim Speicheldrüsenkarzinom unzureichend.
Ascending Aortic Aneurysms <4.5 cm for Nonsyndromic Adults: Very Slow Growth and Low Risk
Authors: Hiratzka Loren F. , Hanlon Tiffany , Vorpe Katherine 
Published: December 2022

AbstractBackground Current practice guidelines for patients with thoracic aortic aneurysms (TAAs) recommend 6 to 12-month intervals for surveillance imaging based on growth estimates of 0.10 to 0.42 cm/y gleaned from limited studies which included patients with thoracoabdominal aneurysms, known acute or chronic aortic dissection, and other syndromic and nonsyndromic high-risk conditions (TAA-HRC) associated with high-risk for adverse aortic events and death. Our objective was to determine TAA growth and event-free survival rates for patients with aortic root or midascending diameters <5.0 cm, and without thoracoabdominal aneurysms, acute or chronic aortic dissection or higher risk syndromic or nonsyndromic conditions (TAA-NoHRC).Methods A retrospective review of patient records and imaging studies were done. Aortic diameter measurements were all performed by the lead author.Results For 197 TAA-NoHRC found incidentally during chest imaging, with 616 chest imaging studies over 868 patient-years, the mean aortic root and midascending aortic growth rates were 0.018 and 0.022 cm/y, respectively. The growth rate was significantly lower for aneurysms initially measured at <4.5 cm versus ≥ 4.5 cm at both the aortic root (0.011 vs. 0.068 cm/y) and midascending aorta (0.013 vs. 0.043 cm/y). Survival free from adverse aortic events (dissection, rupture, and surgery) or death at 5 years was 99.5%.Conclusion Adult TAA-NoHRC patients with initial aortic root and/or ascending aortic diameters <5.0 cm, and particularly <4.5 cm, have very low aortic growth, and adverse event rates which may permit longer intervals between surveillance imaging, up to 3 to 5 years, after initial (6–12 months) stability is documented.
Indication of Pd–C or Cu–C Intermediates in Bimetallic Nanoclusters During Pd/Au-PVP- or Cu/Au-PVP-Catalyzed Oxidations of endo-4-Oxatricyclo[5.2.1.02,6]-8-decene and Tetrahydro-γ-carbolines
Authors: Hua Duy H. , Morita Shunya , Ren Zhaoyang , Gorla Lingaraju , Tong Zongbo , Edouarzin Edruce , Averkiev Boris , Day Victor W. 
Published: December 2022

AbstractCatalytic oxidation of tricyclic endo-norbornene-fused tetrahydrofuran with the bimetallic nanocluster Cu/Au-PVP in the presence of H2O2 or t-BuOOH as the oxidant leads to C–H bond oxidation adjacent to the ether function to give 4-oxa-tricyclo[5.2.1.0]-8,9-exo-epoxydecane, however, oxidation with Pd/Au-PVP takes place at the C=C double bond to give the same epoxide and the oxidative three-bond forming dimeric product, dodecahydro-1,4:6,9-dimethanodibenzofurano[2,3-b:7,8-b′]bisoxolane. Formation of the latter product suggests the involvement of a reactive Pd–C intermediate. Similarly, oxidative C–C bond-forming reactions are observed in cycloaddition reactions of N2-Boc-1,2,3,4-tetrahydro-γ-carbolines and 2,3-dihydroxybenzoic acid with Cu/Au-PVP (2–5 mol%) and H2O2 at 25 °C, providing two-bond-forming [4+2] cycloadducts. Under similar reaction conditions, Pd/Au-PVP did not produce the corresponding cycloadduct, indicating a need for complexation between Cu and the carboxylic acid group of 2,3-dihydroxybenzoic acid and the allylic amine function of the γ-carbolines during the cyclization reaction. The reported intermolecular coupling reactions using Pd/Au-PVP or Cu/Au-PVP nanocluster catalysts under oxidative conditions at 25 °C are unprecedented.
Rh(III)-Catalyzed Stereoselective C–H Homoallylation of Indolines with 4-Vinyl-1,3-dioxan-2-ones
Authors: Wan Jie-Ping , Sun Meng , Zhang Zhou , Yi Jun-Jie , Aslam Muhammad 
Published: December 2022

AbstractAn efficient and robust Rh(III)-catalyzed C–H homoallylation of indolines has been developed. Using 4-vinyl-1,3-dioxan-2-one as coupling partner, a range of homoallylic alcohols were prepared in excellent stereoselectivities. The current strategy features high efficiency, good yields, and exceptional functional group tolerance.
Stakeholders’ Consensus to Guide the Minimum Impairment Criteria in Wheelchair Basketball
Authors: Hutchinson Michael , Mason Barry , Goosey-Tolfrey Victoria 
Published: December 2022

AbstractThe International Paralympic Committee athlete classification code mandates sports to have defined minimum impairment criteria, describing the minimum level of an eligible impairment an athlete must possess, to be able to participate in that sport. The aim of this study was to establish stakeholders’ consensus for the minimum impairment criteria in wheelchair basketball. From a pool of 48 expert stakeholders (identified via an international medical and scientific working group), 39 completed a 4-round Delphi survey. Questions were answered on the method of assessing each eligible impairment, and the level of impairment that should constitute the minimum impairment criteria. This study indicated where stakeholder consensus existed and noted that consensus was developed for impaired muscle power, impaired passive range of motion, leg length difference, hypertonia and ataxia. No consensus was found for limb deficiency and athetosis. Participants raised concerns with using subjective measurement scales for assessing certain impairments, whilst also calling for more quantitative research to be conducted into the level of impairment that should constitute the minimum impairment criteria. For these research findings to form practical minimum impairment criteria that are part of a wheelchair basketball classification system, it is required to examine their feasibility by conducting further research.
Retroperitoneal Compared to Transperitoneal Approach for Open Abdominal Aortic Aneurysm Repair Is Associated with Reduced Systemic Inflammation and Postoperative Morbidity
Authors: Bailey Damian M. , Rose George A. , O'Donovan Daniel , Locker Dafydd , Appadurai Ian R. , Davies Richard G. , Whiston Richard J. , Bashir Mohamad , Lewis Michael H. , Williams Ian M. 
Published: December 2022

Abstract
Background In the United Kingdom, the most common surgical approach for repair of open abdominal aortic aneurysms (AAAs) is transperitoneal (TP). However, retroperitoneal (RP) approach is favored in those with more complex vascular anatomy often requiring a cross-clamp on the aorta superior to the renal arteries. This study compared these approaches in patients matched on all major demographic, comorbid, anatomic, and physiological variables.
Methods Fifty-seven patients (TP: n = 24; RP: n = 33) unsuitable for endovascular aneurysm repair underwent preoperative cardiopulmonary exercise testing prior to open AAA repair. The surgical approach undertaken was dictated by individual surgeon preference. Postoperative mortality, complications, and length of hospital stay (LoS) were recorded. Patients were further stratified according to infrarenal (IR) or suprarenal/supraceliac (SR/SC) surgical clamping. Systemic inflammation (C-reactive protein) and renal function (serum creatinine and estimated glomerular filtration rate) were recorded.
Results Twenty-three (96%) of TP patients only required an IR clamp compared with 12 (36%) in the RP group. Postoperative systemic inflammation was lower in RP patients (p = 0.002 vs. TP) and fewer reported pulmonary/gastrointestinal complications whereas renal impairment was more marked in those receiving SR/SC clamps (p < 0.001 vs. IR clamp). RP patients were defined by lower LoS (p = 0.001), while mid-/long-term mortality was low/comparable with TP, resulting in considerable cost savings.
Conclusion Despite the demands of more complicated vascular anatomy, the clinical and economic benefits highlighted by these findings justify the more routine adoption of the RP approach for complex AAA repair.
Transition-Metal-Catalyzed Cross-Coupling of Chlorosilanes
Authors: Shu Xing-Zhong , Yang Ying-Hui , Pang Xiaobo 
Published: December 2022

AbstractChlorosilanes are the most accessible feedstock chemical in the organosilicon world. Cross-coupling involving chlorosilanes by transition metal catalysis offers a promising way for the production of organosilanes, which play essential roles in many important research areas, including agriculture, medicinal chemistry, and material science. This chemistry is firstly realized by coupling chlorosilanes with organometallic species and then extended to the silyl-Heck reaction with alkenes. Very recently, the cross-electrophile coupling of chlorosilanes has also been established. In this review, we summarize the progress of this chemistry.1	Introduction2	Cross-Coupling of Chlorosilanes with Organometallic Reagents3	The Silyl-Heck Reaction of Chlorosilanes and Alkenes4	Reductive Cross-Coupling of Chlorosilanes with Electrophiles5	Summary and Outlook
C–C Bond Activations of Minimally Activated Cyclopropanes
Authors: Bower John F. , Sokolova Olga O. , Dalling Andrew G. 
Published: December 2022

AbstractCatalytic processes involving oxidative addition of a C–C bond to a transition metal allow the atom economical assembly of complex scaffolds. The focus of this Account is on C–C bond activation-based methodologies that employ minimally activated cyclopropanes.
Autoimmune Encephalitis with Autoantibodies to NMDAR1 following Herpes Encephalitis in Children and Adolescents
Authors: Quade Annegret , Rostasy Kevin , Wickström Ronny , Aydin Ömer Faruk , Sartori Stefano , Nosadini Margherita , Knierim Ellen , Kluger Gerhard , Korinthenberg Rudolf , Stüve Burkhard , Waltz Stephan , Leiz Steffen , Häusler Martin 
Published: December 2022

AbstractHerpes simplex virus (HSV) type 1 is a frequent pathogen causing infectious encephalitis (HSVE). Early treatment with intravenous acyclovir has led to a significant decrease in mortality. However, especially in children, deterioration during or after HSVE may occur without any evidence of HSV reactivation or improvement following repeated antiviral therapy. Here, we report 15 patients (age range 3 months to 15 years) who suffered from autoimmune encephalitis with autoantibodies to NMDAR1 following Herpes encephalitis, presenting with movement abnormalities (young children) or neuropsychiatric symptoms (older children) as major complaints, respectively. The diagnosis was based on positive cerebrospinal fluid (CSF) and/or serum anti-NMDAR-antibodies with two children showing only positive CSF antibody findings. The time lag between first symptoms and diagnosis of autoimmune encephalitis was significantly longer than between first symptoms and diagnosis of HSVE (p <0.01). All patients improved during immunosuppressive treatment, during which plasmapheresis or rituximab treatments were applied in 11 patients, irrespective of their age. Despite immunotherapy, no patients relapsed with HSVE. Early diagnosis and treatment of autoimmune encephalitis after HSVE may be associated with a better outcome so that high clinical awareness and routine testing for anti-NMDAR-antibodies after HSVE seems advisable. If autoimmune encephalitis is suspected, antibody testing should also be performed on CSF if negative in serum.
Outcomes Post-Nick's Aortic Root Enlargement Technique: Single-Center Experience
Authors: Ashry Amr , Iddawela Sashini , Mishra Vaibhav , Wang William , Mohammed Heba M. , Harky Amer , Mostafa Mohammed M. 
Published: December 2022

Abstract
Background Different techniques for aortic root enlargement (ARE) have been reported in the literature. Each technique comes with its own advantages and disadvantages. We report our outcomes of Nick's technique for ARE.
Methods A single-center retrospective data analysis of 31 patients was performed. Patients were operated between May 2015 and November 2017 at Assuit University Heart Hospital, Assuit, Egypt.
Results The median cardiopulmonary bypass time was 125 minutes (range: 90.0–160.0 minutes), with 90 minutes of cross-clamp (range: 60.0–110.0 minutes). Altogether 59% of the patients had mixed aortic valve diseases. Median intensive care unit and total hospital stay were 2 and 5 days, respectively. Patient-prosthesis mismatch was reported in one patient only (3.25%). Two patients died within 30 days. Median pressure gradient across the aortic valve was 20 mm Hg at 3 years of follow-up.
Conclusion The benefits of Nick's technique for ARE can be demonstrated in populations with younger patients and complicated pathology. Further research is required in larger patient populations.
Tenosynovial Giant Cell Tumor of Foot in a Patient with Radioiodine-Refractory Thyroid Cancer: Imaging Findings on FDG-PET/CT, MRI, and Radioiodine Scan
Authors: Loharkar Sarvesh , Basu Sandip 
Published: December 2022

AbstractWe herein illustrate a case of benign tenosynovial giant cell tumor, which was incidentally detected as FDG-avid lesion on PET/CT in a patient with radioiodine refractory thyroid cancer, with predominantly non-iodine concentrating disease. The lesion was followed up clinically and with local MRI annually for subsequent 3 years. The utility of hybrid PET-CT imaging, the non-iodine concentration of the tumor along with clinical knowledge, and findings on other imaging and pathological modalities in answering and diagnosing incidental benign musculoskeletal tumors in a patient with known thyroid malignancy are presented here.
Effect of COVID-19 on Serum Activity of Liver Enzymes: Is This Associated with Severity and Mortality Rate?
Authors: Alavian Seyed Ehsan , Mofidi Mohammad , Shahabipour Fahimeh 
Published: December 2022

Abstract
Introduction Coronavirus disease 2019 (COVID-19) is a viral infection caused by a novel coronavirus known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease raises an enormous public health challenge for the international community. Liver enzymes have been reported to be frequently elevated in hospitalized patients with severe COVID-19 disease.
Materials and Methods This article is a narrative review of abnormal liver tests and liver injury as a manifestation of progression to severe pneumonia. We collected data from the PubMed database (National Library of Medicine, Bethesda, Maryland, United States). We used the search term “abnormal liver test” and relevant records were measured. The review article was organized thematically.
Results This narrative review aims to summarize the available clinical data on abnormal liver enzymes in coronavirus infection and its association with the risk of mortality, severer pneumonia, and systemic inflammation. Some clinical studies refer to abnormal liver tests and liver injury as a manifestation of progression to severe pneumonia. Recent research verified the relationship between hepatic liver enzyme activities and liver damage in patients with COVID-19, which suggested that it might reflect the infection severity and the mortality risk. Thus, this review investigated the correlation between liver serum enzymes level and the severity of COVID-19 patients, by reviewing investigating the relationship between the illness severity in COVID-19 patients with abnormal liver tests, liver pathology, and markers of inflammation.
Conclusion In the current pandemic of SARS-CoV-2, abnormalities of liver enzyme tests were commonly observed in patients with COVID-19. However, because of multiorgan damages that observed in COVID-19 patients, various issues should be considered such as the pathology and pathophysiology of the liver tissue, especially on the activation process of the immune response and cytokine storm to prevent the severity of the disease.
Plasmonic properties of composition graded spherical nanoparticles in quasi-static approximation
Authors: Galiautdinov Andrei , Zhao Yiping 
Published: December 2022

Abstract
During the operation of a localized surface plasmon resonance (LSPR) sensor made in the form of a core–shell nanoparticle with the shell acting as a sensing layer, the target molecules penetrate into the shell due to intrinsic diffusion or reaction mechanisms. As a result, these molecules or various reactants are nonuniformly distributed in the shell layer. Such sensing particles are termed composition graded plasmonic particles, and their LSPR characteristics may be quite different from those of the uniform core–shell particles. Here, under the quasi-static assumption, a perturbation theory is developed to predict the LSPR properties of composition graded plasmonic particles. The effects of the composition gradient on the LSPR properties due to a metal hydride, a dielectric, and an effective medium are either numerically calculated or analytically derived. Our results show that various configurations of the composition gradient can tune the location and the amplitude of the LSPR peak. The results are important for understanding the sensing performance of composition graded plasmonic particles, and the perturbative treatment presented here can also be used for other composition graded structures.
Superconductivity in the cobalt-doped V3Si A15 intermetallic compound
Authors: Zeng Lingyong , Zhou Huawei , Du Hong , Zhong Ruidan , Guo Ruixin , Guo Shu , Su Wanzhen , Li Kuan , Zhang Chao , Yu Peifeng , Luo Huixia 
Published: December 2022

Abstract
The A15 structure of superconductors is a prototypical type-II superconductor that has generated considerable interest since the early history of superconducting materials. This paper discusses the superconducting properties of previously unreported V3−x
Co
x
Si (0 ⩽ x ⩽ 0.30) alloys. It is found that the lattice parameter decreases with increasing cobalt-doped content and leads to an decreased residual resistivity ratio value of the V3−x
Co
x
Si system. Meanwhile, the superconducting transition temperature (Tc
) also decreases with increasing cobalt-doped content. Furthermore, the fitted data show that the increase of cobalt-doped content also reduces the lower/upper critical fields of the V3−x
Co
x
Si system. Type-II superconductivity is demonstrated in all V3−x
Co
x
Si samples. With higher Co-doped content, V3−x
Co
x
Si (0.15 ⩽ x ⩽ 0.30) alloys may have superconducting and structural phase transitions in low-temperature regions. As the electron/atom ratio increases, the Tc
variation trend of V3Si is as pronounced as in crystalline alloys and monotonically follows the trend observed for amorphous superconductors.
A comparison of main bearings load of two-cylinder “V” and boxer motorcycle engines
Authors: Nikolić N , Crnogorac N , Dorić J , Feher D , Galamboš S 
Published: December 2022

Abstract
The paper deals with determining the load of the crankshaft main bearings in two-cylinder motorcycle engines. Two cylinder arrangements, used in two-cylinder motorcycle engines, are considered - the boxer-engine and V-engine. The aim of the research is to determine the influence of cylinder arrangement on the magnitude and circumferential distribution of the bearing load of the engines considered. For this purpose, models of a two-cylinder boxer engine and a corresponding V-engine crankshaft drives were developed using multibody dynamics simulation software. Previously, by using a one-dimensional gas analysis software the engine cycles were simulated in order to determine the cylinder pressure required to simulate piston dynamics. As a result of the dynamics simulations, bearing load diagrams of the boxer- and V-engine were obtained, which were then compared and analyzed.
In-vehicle comfort assessment during fore-and-aft random vibrations based on artificial neural networks (ANN)
Authors: Mačužić Saveljić S , Arsić B , Saveljić I , Lukić J 
Published: December 2022

Abstract
Driving comfort is one of the important factors for vehicle users. There is a lot of research related to comfort or discomfort in a vehicle but there is still no well-defined way to assess it accurately. In this paper, an assessment of vehicle comfort during fore-and-aft random vibrations was made based on measured and predicted r.m.s. acceleration values. Measured values of r.m.s. accelerations were obtained by laboratory testing while the predicted values of r.m.s. accelerations obtained based on the ANN (Artifical Neural Network) model. 20 male subjects participated in the study. Their different anthropometric characteristics of the body were taken into account. Based on the measured r.m.s. values of acceleration formed ANN model which has ability to predict r.m.s. acceleration values based on measured values. The obtained results showed high accuracy of the model.
Regenerative braking on electric vehicles: working principles and benefits of application
Authors: Vasiljević S , Aleksandrović B , Glišović J , Maslać M 
Published: December 2022

Abstract
The application of electric vehicles leads to a change in the principle of operation and functioning of some systems in the vehicle, which also lead to a change in the concept of the vehicle itself. One of those systems that has a new concept, which differs from vehicles powered by IC engines, is the braking system. The previous function of the braking system was to stop the vehicle, i.e. to reduce the speed of the vehicle in a safe way. In the case of electric vehicles, the friction brakes were retained, with the addition of a regenerative braking system that has the role of replenishing the vehicle's batteries. The regenerative braking system has the role of converting the vehicle's kinetic energy into electrical energy that recharges the batteries. This system is already used today on full electric and hybrid vehicles, i.e. on vehicles powered by an electric motor. The benefits of regenerative braking are reflected on the fact that the vehicle batteries are recharged during braking, vehicle maintenance costs are reduced, the service life of discs and drum brakes on the vehicle is extended, brake non-exhaust emission is reduced, and heat energy emission is reduced, too.