bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial dynamics-related genes Drpl and Opal contributes to early diagnosis of cognitive impairment in diabetes
Authors: Liu Mengqian , Gong Chen , Shen Xiaozhu , Jiang Yi , Xu Yiwen , Zhong Wen , Chen Yujiao , Dong Nan , Liao Jingxian , Yin Ning 
Published: April 2023

Abstract
Background and aim DRP1 and OPA1 play important roles in mitochondrial fusion and fission. However, the role of DRP1 and OPA1 amplification in mitochondrial cognitive impairment has not been reported. This study aimed to investigate the relationship between DRP1 and OPA1 and the risk of cognitive impairment.Methods A total of 45 elderly patients with diabetes were enrolled in this study, including 15 patients with normal diabetes, 15 patients with mild cognitive impairment (MCI), and 15 patients with dementia. Also, the clinical characteristics, AD8 score, and MoCA score were evaluated.Results DRP1(2-K) and OPA1(2-K) significantly increased and decreased in dementia and MCI groups compared with the normal group (P ≤ 0.001). DRP1 gene amplification was positively correlated with the AD8 score and negatively correlated with the MoCA score (P < 0.001). OPA1 gene amplification was positively correlated with the MoCA score (P = 0.0002). Receiver operating characteristic analysis showed that OPA1 amplification had a high predictive value for dementia (P < 0.0001), and the combination of OPA1 and DRP1 had a higher predictive value.Conclusion Multiples of DRP1 and OPA1 are associated with dementia risk in elderly patients and may serve as potential biomarkers.
CS-YOLO: A new detection algorithm for alien intrusion on highway
Authors: Lou Haitong , Guo Junmei , Chen Haonan , Liu Haiying , Gu Jason , Bi Lingyun , Duan Xuehu 
Published: April 2023

Abstract
In recent years, highway accidents occur frequently, the main reason is that there is always foreign body invasion on the highway, which makes people unable to respond to emergencies in time. In order to reduce the occurrence of highway incidents, an object detection algorithm for highway intrusion was proposed in this paper. Firstly, a novel network structure was proposed to improve the feature extraction ability. Secondly, a new feature fusion method was proposed to improve the accuracy of object detection. Finally, a lightweight method was proposed to reduce the computational complexity. We compare the algorithm in this paper with existing algorithms, the experimental results showed that: On the Visdron dataset (small targets), CS-YOLO improves by more than 3.6%; On the Tinypersons dataset (extremely small targets), CS-YOLO improves by more than 1.2%. On the PASCAL VOC2007 dataset (normal size), CS-YOLO improves by more than 1.4%.
Buffering or Deteriorating: How Filial Piety Influences the Associations Between Elder Abuse, Social Well-being, and Depression among Chinese Older Adults
Authors: Sun Xin , Yan Zi 
Published: April 2023

Abstract
Background Few empirical studies have examined how cultural values and social well-being affect depression amongst victims of elder abuse. This study thus incorporates the cultural context into a stress-and-coping model to explore how filial piety influences the dynamic associations between elder abuse, multi-dimensional social well-being, and depression among older adults in China.Methods The participants were 7,700 older adults (aged 60 years or older) enrolled in the 2018 China Longitudinal Aging Social Survey, a national population-based study of older adults. Moderated mediation models were applied to test the mediating effects of multidimensional social well-being (social isolation, loneliness, social network, and social participation) and the moderating effect of filial piety. All mediation and moderated mediation effects were estimated using SPSS.26.Results Different dimensions of social well-being have a partial mediating effect on the association between elder abuse and depression. Traditional attitudes towards filial piety exacerbated the effects of elder abuse on depression by increasing social isolation and loneliness, but they also reversed some negative effects by improving the social network.Conclusions Certain sociodemographic factors are associated with greater risk of depression for victims of elder abuse. Our findings suggest that filial discrepancy and stigma from elder abuse might influence not only older adults’ feelings of loneliness and social isolation but also their social participation and social network; this will further deteriorate their depressive symptoms in late life. These results should be considered when developing culturally sensitive identification, prevention, and intervention services for older adults.
Efficacy and Safety of Nab-Paclitaxel Chemotherapy for Patients with Gastric Carcinoma: A Systematic Review and Single Arm Meta-analysis
Authors: Madeeh Alyaa Khaled , Farouk Hossam Khaled , Belal Mohamed Mohamed , Ramadan Sara , Al-Masri Batool Emad , Samier Mohamed , Gadallah Salama Ahmed , Khapoli Naseba , Nashwan Abdulqadir J. , AbdelQadir Yossef Hassan 
Published: April 2023

Abstract
Aim This study aims to investigate the efficacy of nab-paclitaxel mono-chemotherapy as a second-line treatment for previously treated adenocarcinoma patients.Methods We conducted a systematic review and meta-analysis of prospective single-arm clinical studies that tested nab-paclitaxel monotherapy for treating gastric carcinoma. The review was conducted in accordance with PRISMA.Results We included 6 studies with a total of 271 patients. The pooled analysis of response rate, overall survival, and progression-free survival were 0.21 (95% CI: [0.16,0.28]), 11.65 (95% CI: [10.56, 12.75]), and 2.983 (95% CI: [2.625, 3.342]), respectively. There was no statistically significant difference between the doses regarding response rate and progression-free survival. However, the overall survival of the 150 mg/m2 dose was statistically significantly higher than the 260 mg/m2 dose. The treatment was associated with manageable toxicity profiles.Conclusion Nab-paclitaxel mono-chemotherapy is an effective treatment option for previously treated and recurrent gastric cancer with a manageable toxicity profile. Future studies should aim to compare Nab-paclitaxel to other agents in direct head-to head comparison.
Study protocol for a randomized controlled trial investigating the effect of online interpretation bias intervention on stress reactivity in the children of parents with depression: the CoCo study
Authors: Frommelt Tonya , Bäumler Leonie , Schulte-Körne Gerd , Platt Belinda , Rohleder Nicolas 
Published: April 2023

Abstract
Background Current preventive interventions for the children of parents with depression demonstrate modest effects on depression incidence. This may be because existing interventions tend to comprise general psychotherapeutic tools, rather than targeting the specific mechanisms underlying familial transmission. Improved theoretical models of familial transmission could enhance the development of targeted interventions. Although existing models assume that cognitive and biological vulnerability factors influence one another, the precise mechanisms are unknown. This project is the first to experimentally test whether negative interpretation bias has an impact on cortisol response in children of parents with depression. This study protocol reports a randomised controlled trial of an interpretation bias intervention which aims to shift participants’ interpretation bias in a more positive direction and thereby alter their stress response.Methods Children aged 10–14 years who have i) one parent with a current or previous depression diagnosis, with at least one episode occurring during the child’s lifetime and ii) do not have a current or previous psychiatric diagnosis themselves, will be assigned to one of two conditions: an interpretation bias intervention (n = 50) or a structurally similar placebo intervention (n = 50). The interpretation bias intervention consists of a short lab-based cognitive reappraisal of interpretations training, a four-week app-based Cognitive Bias Modification of Interpretations intervention and interpretation bias specific if-then plans. Interpretation bias will be assessed before and after the intervention using the Scrambled Sentences Task. The effect of the intervention on participants’ stress response will be assessed by salivary cortisol collected at five different time points: from immediately before until 45 minutes after administering the Trier Social Stressor Test for Children. Stress reactivity will be measured via baseline to peak cortisol and stress recovery will be measured via the 45 minute cortisol marker. We hypothesise that children who participate in the interpretation bias intervention will display a positive shift in interpretation bias and this, in turn, will alter their stress response. Children who receive the placebo intervention are expected to show a smaller positive shift in interpretation bias and stress reactivity.Discussion The findings of the present study will contribute to models of familial depression transmission as well as informing preventive interventions. If training a more positive interpretation bias subsequently alters participants’ stress response, then incorporating such tools may increase the efficacy of existing preventive interventions.Trial Registration: Deutsches Register Klinischer Studien DRKS00028842. Registered August 19, 2022.
Correlation of NK cell activity and Clinical Parameters with Survival in Breast Cancer patients
Authors: Lee Ga-Young , Cho Jung-Hyo , Son Chang-Gue , Cho Chong-Kwan , Lee Nam-Hun 
Published: April 2023

Abstract

Through analyzing a correlation between natural killer cell activity (NKA) and survival rate of patients with breast cancer, this study aims to assess the potential of NKA as a prognostic biomarker of breast cancer. We retrospectively analyzed the digital medical records of breast cancer patients treated at two traditional Korean medicine hospitals, located in Daejeon and Cheonan, South Korea, from April 1, 2016, to April 4, 2021. NKA levels were assessed by measuring interferon-γ released by stimulated- NK cells using commercial kit (NK Vue®; NKMAX, Seongnam, Korea). The patients were divided into two groups: A high NKA (≥ 500 pg/mL), and a low NKA (< 500 pg/mL) group, and compared in terms of tumor progression, physical status, overall survival (OS), and event-free survival (EFS). The high-NKA group exhibited significant longer OS (67.3 ± 1.5 vs 57.4 ± 3.7 months, p=0.002), longer EFS (62.9 ± 2.0 vs 49.2 ± 3.8 months, p=0.004) and better response rate (84.5% vs 69.8%, p=0.021). A relationship between NKA and prognosis in stage III and IV was more significant. Stage III and IV patients with high NKA had longer OS (38.9 ± 6.8 vs 56.7 ± 5.5 months, p = 0.039) and longer EFS (50.5 ± 6.2 months vs 31.4 ± 6.3 months, p = 0.053). NKA may serve as a prognostic biomarker for breast cancer patients. Further studies with more patients over a longer period are needed.
A randomized trial to evaluate the effects of a supervised exercise program on insomnia in patients with non-metastatic breast cancer undergoing chemotherapy: design of the FATSOMCAN study
Authors: Drozd Chloé , Curtit Elsa , Jacquinot Quentin , Marquine Charlène , Mansi Laura , Chaigneau Loïc , Dobi Erion , Viot Julien , Meynard Guillaume , Paillard Marie-Justine , Goujon Morgan , Roux Pauline , Vernerey Dewi , Gillet Valérie , Bourdin Hubert , Galli Silvio , Meneveau Nathalie , Mougin Fabienne 
Published: April 2023

Abstract
Background
Up to 70% of breast cancer patients report symptoms of insomnia during and after treatment. Despite the ubiquity of insomnia symptoms, they are under-screened, under-diagnosed and poorly managed in breast cancer patients. Sleep medications treat symptoms but are ineffective to cure insomnia. Other approaches such as cognitive behavioral therapy for insomnia, relaxation through yoga and mindfulness are often not available for patients and are complex to implement. An aerobic exercise program could be a promising treatment and a feasible option for insomnia management in breast cancer patients, but few studies have investigated the effects of such a program on insomnia.
Methods
This multicenter, randomized clinical trial evaluate the effectiveness of a moderate to high intensity physical activity program (45 minutes, 3 times per week), lasting 12 weeks, in minimizing insomnia, sleep disturbances, anxiety/depression, fatigue, and pain, and in enhancing cardiorespiratory fitness. Patients with breast cancer be recruited from six hospitals in France and randomly allocated to either the “training” or the “control” group. Baseline assessments include questionnaires [Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index questionnaire (PSQI), Hospital Anxiety Depression Scale (HADS), Epworth Sleepiness Scale (ESS)], home polysomnography (PSG), and 7-day actigraphy coupled with completion of a sleep diary. Assessments are repeated at the end of training program and at six-month follow-up.
Discussion
This clinical trial will provide additional evidence regarding the effectiveness of physical exercise in minimizing insomnia during and after chemotherapy. If shown to be effective, exercise intervention programs will be welcome addition to the standard program of care offered to patients with breast cancer receiving chemotherapy.
Trial registration: National Clinical Trials Number (NCT04867096)
A first attempt to track genetic signature of the colonization of the Mediterranean basin by the pigmy white-toothed shrew, Suncus etruscus (Eulipotyphla, Soricidae)
Authors: Castiglia Riccardo , Rotondi Chiara , Aloise Gaetano , Amori Giovanni , Annesi Flavia , Solano Emanuela , Mori Emiliano 
Published: April 2023

Abstract
The pigmy white-toothed shrew Suncus etruscus is a widespread species whose distribution patterns are unclear. Paleontological data suggested an east-west pattern of dispersion in the Mediterranean basin during late Holocene but some doubts are still present especially considering the absence of fossil remains from key areas, as mainland Italy. Here we propose, a preliminary screening of the phylogeographic relationships among Italian pigmy white-toothed shrews and other Mediterranean areas. The Italian haplotypes were all very similar without an evident geographic structure, however we evidenced that the haplotype from Israel, the putative source area for the Mediterranean basin, is almost identical to the most common Italian haplotype. This excludes an ancient event of vicariance between the two areas and we can assume that these haplotypes arrived in the central Mediterranean through the eastward wave of colonization, in agreement with the relatively recent arrival of the species in the area.
Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological changes
Authors: Yoshida-Tanaka Kugui , Ikemoto Ko , Unoki Motoko , Takano Takako , Fujimoto Akihiro 
Published: April 2023

Abstract
Complex congenital chromosome abnormalities are rare but often cause severe symptoms. The structures and biological impacts of such chromosome abnormalities have seldomly been analyzed at the molecular level. Previously, we reported a Japanese female patient with severe developmental defects. The patient had an extra dicentric chromosome 21 (chr21) consisting of two partial chr21 copies fused together within their long arms along with two centromeres and many copy number changes. In this study, we performed whole-genome, transcriptional, and DNA methylation analyses, coupled with novel bioinformatic approaches, to reveal the complex structure of the extra chromosome and its transcriptional and epigenetic changes. Long-read sequencing accurately identified the structures of junctions related to copy number changes in the extra chr21 and suggested the mechanism of the structural changes. Our allele-specific transcriptome analysis showed the overexpression of genes in extra chr21. Additionally, allele-specific DNA methylation analysis of the long-read sequencing data suggested that the centromeric region of extra chr21 was hypermethylated, which may cause inactivation of one centromere in the extra chromosome. Our comprehensive analysis provides insights into the molecular mechanism underlying the generation of the extra chromosome and its pathogenic roles.
Construction of a predictive nomogram for functional recovery after Bernese Periacetabular Osteotomy
Authors: Du Panzhihao , Gu Yange , Jin Wenshu , Li Shufeng , Yue Yaohui , Yin Luxu , Li Zhongxin , Wang Keke , Zhao Zhang , Yan Xinfeng , Sun Huaqiang 
Published: April 2023

Abstract
Background and purpose There are recognized surgical indications for Bernese periacetabular osteotomy (PAO), but the degree of postoperative functional recovery is significantly different through clinical observation and follow-up. Therefore, it is necessary to do a preoperative evaluation. This study aims to screen the factors influencing functional recovery after PAO and construct a predictive nomogram.Patients and methods: Retrospective data were collected between December 2016 and March 2022 at The First Affiliated Hospital of Shandong First Medical University, including demographic data and imaging materials of patients undergoing PAO. The least absolute shrinkage and selection operator regression was used to screen the influencing factors, and then multivariate logistic regression analysis was employed to construct a predictive nomogram for predicting functional recovery after PAO.Result The influencing factors of functional recovery after PAO were screened out, namely the preoperative distance from the innermost surface of the femoral head to the ilioischial line, surgical approach, preoperative acetabular depth, and preoperative Calve line continuity. A nomogram model was established using these significant predictors. The receiver-operating characteristic curve was drawn, and the area under the curve was calculated to be 0.864. The calibration curve showed that the constructed nomogram model was well calibrated. There was sufficient consistency between the observed and estimated prediction probabilities to indicate that the clinical prediction model had high accuracy.Conclusion This predictive nomogram can identify the patients most suitable for PAO and can be used to guide the selection of surgical patients and surgical approaches.
The Snowball Effect of Financial Activity Resilience and Growth In Indonesia
Authors: Basmar Edwin , Salim Zamroni , Rahman Abdul , Takhim Muhamad , Basmar Erlin , III Carl M. Campbell 
Published: April 2023

Abstract

Increasing resilience and growth is financial activity indication, but snowball effect can occur in reverse. This study aims to determine level between macroeconomic as measured by the snowball pressure effect using Ed Waves Index development. The findings show that average pressure wave α is -4.6 Amplitude and β is -5.8 Amplitude, the response to pressure wave λ is -15 Amplitude, identification shows that financial activity is in acute depression through high sensitivity level and real financial stability that is not optimal. The study results can serve as early indicators in maintaining financial resilience and economic growth in Indonesia.
JEL Classification : E32, E42, E52, E58
The Role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer
Authors: Yuan Hui , Liang Yu , Hu Shaorun , Chen Jinxiang , You Jingcan , Jiang Jun , Zeng Min , Luo Mao 
Published: April 2023

Abstract

Background Breast cancer is a common malignancy with the highest mortality rate among women worldwide. The Forkhead Box (FOX) transcription factor family is an evolutionarily conserved superfamily that regulates cell growth, differentiation, and tissue development. Increasing evidence suggests that FOX transcription factors play an important role in the occurrence and development of breast cancer. However, little is known about the relationship between the expression, prognostic value, function and immune infiltration of FOX transcription factors in tumor microenvironment.Methods In this research, we studied the expression, prognostic value, gene alteration, functional enrichment and immune cell infiltration of FOX factor in breast cancer patients by using the Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, cBioPortal, String, GeneMANIA, DAVID, TIMER, Cytoscape(version3.9.1)and R software (version 3.6.3).Results The expression levels of FOXA1 and FOXM1 were significantly higher in breast cancer tissues than in normal tissues, while the expression levels of FOXC2 and FOXO3 were lower in breast cancer tissues than in normal tissues. The high expression of mRNA in FOXA1, FOXM1 and FOXP1 groups was related to tumor stage. Survival analysis results showed that increased FOXP1 mRNA levels were significantly associated with overall survival (OS), recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) in all breast cancer patients (p < 0.05). Patients with the FOXA1 high-expression group had better RFS and DMFS than the low-expression group (p < 0.05), while patients with FOXM1 high-expression group had worse RFS, OS and DMFS than the low-expression group (p < 0.05). FOXP1, FOXA1 and FOXM1 can be used as potential biomarkers to predict the prognosis of breast cancer patients. Functional enrichment indicated that FOX was mainly involved in cell division, cell senescence, cell cycle and prolactin signaling pathway. In addition, FOX mRNA expression was strongly associated with the infiltration of multiple immune cells, including six types of B cells, CD4 + T cells, CD8 + T cells, macrophages, neutrophils, and dendritic cells in breast cancer.Conclusion These findings may provide novel insights into the screening of prognostic biomarkers of the FOX family in breast cancer, and lays a foundation for further research on the immune infiltration of the FOX transcription factor family members in tumors.
Reproductive responses to increased density and global change drivers in a widespread clonal wetland species, Schoenoplectus americanus
Authors: Whigham Dennis F. , Kudoh Aoi , Megonigal J. Patrick , Langley J. Adam , Noyce Genevieve L. , Sakai Toshiyuki 
Published: April 2023

Abstract
The expansion of many wetland species is a function of both clonal and sexual propagation. The production of ramets through clonal propagation enables plants to move and occupy space, while seeds produced by sexual reproduction enable species to disperse and colonize open or disturbed sites. The balance between clonal propagation and sexual reproduction is known to vary with plant density but few studies have focused on reproductive allocation with density changes in response to global change. Schoenoplectus americanus is a widespread clonal wetland species in North America and a dominant plant in a Chesapeake Bay brackish tidal wetland. Long-term experiments on responses of S. americanus to global change provided the opportunity to compare the two modes of propagation under different treatments condition. Seed production increased with increasing shoot density, supporting the hypothesis that factors causing shoot density to increase stimulate sexual reproduction and dispersal of genets. The increase in allocation to sexual reproduction was mainly the result of an increase in the number of ramets that flowered and not an increase in the number of seeds per reproductive shoot, or the ratio between the number of flowers produced per inflorescence and the number of flowers that developed into seeds. Seed production increased in response to increasing temperatures and decreased or did not change in response to increased CO2 or nitrogen. Results from this comparative study demonstrate that plant responses to global change treatments affect resource allocation and can alter the ability of species to produce seeds.