bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Involvement of Service Users and People With Lived Experience in Mental Health Care Innovation Through Design: Systematic Review
Authors: Veldmeijer Lars , Terlouw Gijs , Van Os Jim , Van Dijk Olga , Van 't Veer Job , Boonstra Nynke 
Published: June 2023

Background
Mental health care faces challenges that not only necessitate innovation but also require the involvement of service users and people with lived experience in developing and evaluating mental health care services. As the development of digital interventions is becoming more prevalent, design approaches are increasingly finding their way into mental health. There is evidence that these approaches can successfully integrate user experience into mental health services. However, there is no clear overview of the studies conducted and the lessons learned concerning the involvement of service users and people with lived experience.

Objective
In this systematic review, we aimed to provide an overview of the involvement of service users and people with lived experience in mental health care services through design approaches and to synthesize the advantages of design approaches in mental health care.

Methods
The following 5 databases were searched for relevant abstracts: PsycINFO, PubMed, Web of Science, Scopus, and Embase. In addition, 2 health design journal archives, Design for Health and The Journal of Health Design, were searched. To categorize the results, we collected the reported added value from the included articles and conducted a thematic synthesis in which the themes were developed from the retrieved data. The themes were discussed, revised, and checked until saturation was achieved.

Results
We included and categorized 33 papers. Most studies involved service users, primarily adults, and used various design approaches. Most of these studies aimed to design or evaluate digital interventions. Service users and people with lived experience were involved in different roles but never as decision makers. Studies that used co-design approaches exhibited the highest levels of involvement. Various added values were reported, including tailoring and testing interventions and digital interventions, improving engagement and collaboration, gathering the needs of stakeholders, and empowering participants as resourceful actors. The challenges reported were maintaining participants’ continued participation throughout the study, managing the iterative nature of design, providing a safe space, balancing insights from design and medical science, and navigating design processes in medical environments.

Conclusions
This systematic review provides an overview of the studies that used design approaches to involve service users and people with lived experience in mental health care innovation. Design approaches have advantages in mental health care innovation, offering added value and having manageable challenges. Future studies using design approaches in mental health care should involve participants as partners and decision makers and report on collaboration in a systematic and clear manner.
Utilisation of Oral Health Services and Associated Factors in a Sub-Urban Population in Western Uganda
Authors: Chikuni Wellington , Amalimeh Benedict Erhite , Agholor Collins Nimbiye 
Published: June 2023

Aim: To determine the prevalence and factors affecting the level of utilization of oral health services in a sub urban adult population in Ishaka-Western Uganda.
Methods: A community-based cross-sectional study was conducted among 384 study participants. Data was collected using pre-tested and structured questionnaires. Data was entered in Epi-info computer software version 3.5.1 and exported to STATA Version 14.0 for analysis. Univariate analysis and modified Poisson regression were done to identify factors associated with utilization of oral health services. Crude prevalence ratios with 95% confidence interval were used to determine the level of significance at bivariate meanwhile adjusted prevalence ratios were calculated at multivariate analysis to establish independent significant factors.
Results: The mean age of the study participants was 30.22 ± 9.97. It was observed that 36.72% of the study participants had utilized oral health services. Factors affecting utilization of oral health services that were statistically significant were level of education (tertiary level of education versus none) (P<0.001), average monthly income of >1,000,0000 Shilings (about $300) versus <501,000 ( about $150) (P<0.001), no phobia for dental procedures (P=0.035), perception that oral health visits are important (P=0.017) and positive attitude of attending health workers ( P=0.028).
Conclusion: This study has shown that the level of utilization of oral health services in the studied suburban adult population was poor. The level of education, income and phobia for dental procedures were associated with the utilization of oral health services. It is recommended that oral health promotion strategies be deployed in order to increase awareness and access to oral health care.
Keywords: Oral health services, community-based cross-sectional study, Uganda
Dual immune checkpoints inhibition: Cancer treatment and immunological modes of action
Authors: Ramteke Ashish S. 
Published: June 2023

Programmed death receptor 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) are immune checkpoint inhibitors that are effectively esteemed destinations of immunotherapies for the management of melanoma and several cancers. The monotherapy included monoclonal antibodies approved such as Ipilimumab, Pembrolizumab, and Nivolumab planned to restrict with T-cell inhibitory signals to activate the immune responses to cancers. Combined treatment of immune checkpoint blockers can promote results compared to monotherapy in specific patient groups and these clinical advantages can be reported from particular immune mechanisms of action. Although, treatment with checkpoint blockers combinations are present important clinical challenges and raised rates of immune related adverse incidents.
Keywords: Cancer, Checkpoint Inhibitors, T-cell, Immunotherapy, Biomarker
Comparative Spermatogenesis Activity of Eranda Moola (Ricinus Communis) Collected In Different Seasons as per Dravya Samgrahana Kaala: An Experimental Study
Authors: Bingi Ashok , Mallya Suma V 
Published: June 2023

Introduction: Dravya sangrahana is one of the criteria where different seasons are indicated for collecting different parts of the plants. As per ancient drug collection practice roots are to be collected in Hemanth-Shishira (winter) or Greeshma rutu(summer). Eranda(Ricinus communis) is an important medicinal plant roots of which are particularly indicated as Vrishya (spermatogenic). Hence study has been planned to conduct a comparative spermatogenic activity of Ernadamoola collected in Greeshma rutu and Pravarat rutu and Shishsira ritu. Materials and methods: Roots of Eranda(Ricinus communis) collected during Pravrut Ritu (EMP), Greeshma Ritu (EMG) and Shishira Ritu (EMS) shade dried separately, powdered. Spermatogenic activity study conducted on healthy albino rats divided among five groups. Testosterone was used as standard drug, whereas other three groups received sample collected in three different seasons for a period of 60 days. Next sperm analysis and histopathological study of prostate and seminal vesicle was conducted. Discussion and conclusion: Erandamoola(roots of Ricinus communis) has shown best spermatogenesis activity in experimental animals proving our ancient quotation as Vrishya. Also roots collected in different seasons have shown their difference among activity. Histopathological study of genital organs also shown positive result among spermatogenic activity.
Key words: Dravya sangrahana, Eranda(Ricinus communis), Vrishya, spermatogenesis activity
Steroids Induced Hyperglycemia: Its Effects and Management
Authors: Akshaya N , Krishna Ravi , Venkateswaramurthy N 
Published: June 2023

Steroids are medications that have been widely utilized for a number of ailments, both acute and chronic. The action of endogenous steroids, nuclear hormones that penetrate cell membranes to bind to certain glucocorticoid receptors in the cytoplasm of target cells to form glucocorticoid-receptor (GR) complexes, is mimicked by synthetic glucocorticoids. The translocated activated GR complex regulates DNA transcription in the cell nucleus. The main factor for drug-induced hyperglycemia is steroids. They not only worsen hyperglycemia in those who already have diabetes mellitus (DM), but they can also lead to DM in people who've not previously experienced it. Their incidence can reach up to 46% of patients, and their glucose levels can rise by up to 68% over baseline. Steroid effects are often narrow and reversible. Drug-induced diabetes is supposed to go away as steroid doses are decreased because their impact on endocrine metabolism returns to normal; however, this is often not the case. The synthesis of lipolysis, proteolysis, and hepatic glucose is increased by glucocorticoids (GCs) because they act as a substrate for oxidative stress metabolism. A wide range of medical conditions has been treated with GCs. Although steroid-induced hyperglycemia has been proven to be medically effective, it is still a widespread and potentially dangerous issue that must be taken into consideration when administering any GC dose. The most common scenario requires the use of insulin, particularly when the serum glucose level is greater than 200 mg/dL.
Keywords: Steroids, Glucocorticoids, Hyperglycemia, Resistance, Insulin
High concentration Amiodarone continuous infusion induced Phlebitis: A Case Report
Authors: Gonenavar Madhusoodan M , Kulkarni Vishal , Prasad Rashmi , Shirol Gulam Mohiyuddin N , Sirdesai Nida Khanum 
Published: June 2023

Phlebitis caused by high concentration amiodarone infusion is a rather uncommon occurrence. Phlebitis is one of the most reported causes of high concentration amiodarone continuous infusion in bradycardia. We reported a case of patient with continuous infusion of amiodarone induced phlebitis. Patient felt pain along the path of cannula, erythema, induration, palpable venous cord. Visual Infusion Phlebitis Score was assessed and VIP Score was found to be 4. We suspected the incidence of phlebitis due to high concentration and continuous infusion of IV amiodarone. In this case report, we would like to discuss about the standard protocol of IV administration of amiodarone, evaluation of phlebitis by Visual Infusion Phlebitis Score, and management of Phlebitis.
Keywords: Visual Infusion Phlebitis Score, amiodarone, phlebitis, tachyarrhythmia, peripheral administration.
Kualitas Soft Cookies Berbahan Gula Aren Lokal
Authors: Leonard Komang Aryani Judith , Pambudi Bondan 
Published: June 2023

Tujuan dari penelitian Kualitas Soft Cookies Berbahan Gula Aren Lokal adalah untuk membandingkan dan untuk mengetahui perbedaan kualitas rasa, aroma, tekstur, dan warna yang dihasilkan dari menggantikan bahan pembuatan soft cookies yang umumnya menggunakan light brown sugar, digantikan dengan gula aren lokal. Kemudian penggantian bahan utama pembuatan soft cookies ini ialah untuk menjadikan soft cookies sebagai camilan yang menyehatkan bagi tubuh saat dikonsumsi karena kandungan gula aren lokal sangatlah menyehatkan dibandingkan dengan menggunakan light brown sugar yang mengandung molases yang cukup tinggi. Penulis melakukan eksperimen dengan membuat 3 jenis soft cookies berupa soft cookies yang menggunakan 100% light brown sugar, soft cookies yang menggunakan 100% gula aren lokal (gula aren Pedawa), dan mencampurkan 50% light brown sugar dan 50% gula aren lokal (gula aren Pedawa). Kemudian diuji oleh 20 panelis dengan mengkonsumsi 3 jenis soft cookies yang telah dibuat lalu memberi penilaian terhadap 3 jenis soft cookies tersebut. Penilaian itu berupa kualitas rasa, aroma, tekstur, dan warna yang dihasilkan dari eksperimen soft cookies tersebut. Setelah semua data dari eksperimen tersebut terkumpul, penulis memasukkan data yang diperoleh ke dalam tugas akhir ini yang kemudian di ujikan kepada dosen pembimbing.

The purpose of the study on the quality of Soft Cookies made from palm sugar is to compare and to determine the differences in the quality of taste, aroma, texture, and color resulting from replacing the ingredients for making cookies which generally use light brown sugar, replaced with local palm sugar. Then the replacement of the main ingredient for making soft cookies is to make soft cookies as healthy snack for the body when consumed because the local palm sugar content is very healthy compared to using light brown sugar which contains quite high molasses. The author conducted an experiment by making 3 types of soft cookies that use 100% light brown sugar, soft cookies that use 100% local palm sugar (Pedawa palm sugar), and mix 50% light brown sugar and 50% local palm sugar (Pedawa palm sugar). Then tested by 20 Panelist by consuming 3 types of soft cookies that have been made and then giving an assessment of the 3 types of soft cookies. The assessment is in the form of taste, aroma, texture, and color quality resulting from the soft cookies experiment. After all the data from the experiment was collected, the author entered the data obtained into this final project which was then tested on the supervisor.
DETERMINAN MINAT GENERASI MILENIAL PADA PENGGUNAAN SISTEM PEMBAYARAN E-WALLET LAYANAN SYARIAH LINKAJA
Authors: Ananda Putri , Nuriyah Aminah 
Published: June 2023

Goal: This study aims to determine whether perceptions of usefulness, perceived convenience, perceptions of security, Islamic financial literacy simultaneously affect the interest in using the LinkAja Syariah Service e-wallet payment system.
Method: In this study, researchers used a descriptive quantitative approach with sampling techniques, namely non-probability sampling by distributing questionnaires to 105 respondents in the Jabodetabek area. This research method is multiple linear regression analysis with an error rate of 5%.
Fact/Findings: The results found in this study are (1) the perception of convenience does not affect the interest in using LinkAja Syariah Services. (2) the perception of usefulness has a positive and significant effect on interest in using LinkAja Syariah Services. (3) the perception of security does not affect the interest in using the LinkAja Syariah Service. (4) Islamic Financial Literacy has a positive and significant impact on interest in using LinkAja's Syariah Services. (5) Perception of convenience, perception of usefulness, perception of security and Islamic financial literacy simultaneously have a positive and significant effect on interest in using LinkAja Syariah Services

Keywords : Payment system, e-wallet, perceived ease of use, perceived ease of usefulness, perceived ease of security, Islamic financial literacy, intention to using
Physiotherapy Management in Spina Bifida Cases
Authors: Riantini Ni Putu , Rahayu Umi Budi , Waspada Edy 
Published: June 2023

Spina bifida or neural tube defect (NTD) is a spinal disorder that does not close completely, resulting in disability or developmental failure of the spinal cord. The cause of spina bifida has no definite reason, but there are several factors that are considered to increase the risk, namely folic acid deficiency, family history of spina bifida, and history of taking drugs. Patients with spina bifida will experience weakness in the lower extremity muscles, decreased ability to control urination, and decreased ability to carry out daily activities. The study used a case report study conducted at YPAC Surakarta for boys aged 15 years with spina bifida disorder. Physiotherapy plays a role in optimizing muscle strength, active movement of children, and improving functional abilities by using interventional stretching exercises, myofacial release, strengthening exercises, and a combination of Kegel Exercises and bridging exercises. After being treated for 6 times T1-T6 there was an increase in muscle strength as measured by manual muscle testing (MMT), changes in the range of motion of the joints (LGS) as measured by the goniometer, an increase in functional ability as measured by the Barthel Index. Keywords: Spina Bifida, Physiotherapy, MMT, LGS, Index Barthel
EFIKASI DIRI DALAM PENGGUNAAN TEKNOLOGI INFORMASI BAGI MAHASISWA CALON GURU DI MASA PANDEMI DAN SESUDAH PANDEMI
Authors: Putri Friyanti Intan Ully , Krismiyati Krismiyati 
Published: June 2023

Abstrak – Masuknya Covid-19 dalam dunia pendidikan membuat calon guru dituntut untuk menguasai teknologi dan memiliki self-efficacy tinggi untuk menghadapi perubahan dengan melihat perbandingan pembelajaran secara online dan kemudian kembali lagi ke pembelajaran tatap muka. Self-efficacy adalah keyakinan individu dalam menghadapi keadaan apapun. Sebagai calon guru sangat penting sekali untuk memahami, menguasai dan memanfaatkan teknologi dengan memiliki self-efficacy tinggi agar bisa menyelesaikan masalah pembelajaran dengan baik. Penelitian ini bertujuan mengetahui bagaimana menghadapi masalah self-efficacy dalam perubahan penggunaan teknologi pada masa pandemi dan setelah pandemi Covid-19, calon guru TIK Pendidikan Teknik Informatika dan Komputer di salah satu perguruan tinggi swasta Salatiga yang sedang melaksanakan program praktikum mengajar. Penelitian ini memakai metode kualitatif dan mengumpulkan data melalui wawancara. Melibatkan 10 mahasiswa calon guru sebagai narasumber. Penelitian ini mengidentifikasikan 4 sumber self-efficacy yaitu; Mastery experiences, Experiances of others, Verbal persuasion, Psychological and Emotional influence. Hasil penelitian menunjukkan bahwa dengan empat sumber utama yang diteliti ini sangat mempengaruhi dalam meningkatkan kepercayaan diri bagi calon guru TIK selama pandemi dan setelah pandemi. Akhirnya, penelitian ini menawarkan rekomendasi untuk penelitian lebih lanjut.
A new torquing method for anterior tooth inclination control: a clinical report with a 7-year follow-up
Authors: Noh Hyung-Kyu , Kim Ho-Jin , Park Hyo-Sang 
Published: June 2023

Abstract
Appropriate orthodontic mechanotherapy, particularly in relation to incisor inclination control is a key consideration for successful treatment and the delivery of optimal aesthetics. A novel, easy, safe and effective torquing technique, termed Park’s cervical torque tie, has been devised. A female patient sought orthodontic treatment and presented with a Class II division 2 malocclusion with crowding but a favourable facial profile. The treatment plan involved the distal movement of the maxillary posterior teeth, decrowding and incisor inclination correction. Palatal root movement was applied to the retroclined upper incisors by a novel cervical torque tie. The treatment was successfully completed after the distalisation of the dentition and palatal root movement of the upper incisors. However, following post-treatment cone-beam computed tomography, less bone coverage was evident on the palatal surface of the upper incisors. After a seven year follow-up, the treatment results were well maintained, and cortical bone regeneration was confirmed.
Antioxidant and antimicrobial properties of an extract rich in proteins obtained from Trametes versicolor
Authors: Michalak Katarzyna , Winiarczyk Stanisław , Adaszek Łukasz , Kosikowska Urszula , Andrzejczuk Sylwia , Garbacz Katarzyna , Dobrut Anna , Jarosz Łukasz , Czupryna Wiktoria , Pietras-Ożga Dorota 
Published: June 2023

Abstract

Introduction
Bioactive proteins and peptides generated from fruit, vegetables, meat or fish have great potential as functional food or substitutes for antibiotics. In recent years it has also been demonstrated that the fungus kingdom could be a source of these compounds. The study investigated the bioactivity of an extract of the lignicolous fungus Trametes versicolor and its hydrolysate.

Material and Methods
The fungus was collected in a mixed forest in October, extracted and hydrolysed. To inspect the protein and peptide profiles before and after hydrolysis, matrix-assisted laser desorption/ionisation–time-of-flight mass spectrometric analysis was performed. To evaluate the antioxidant properties of the preparations, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+) radical scavenging assays were used. The activity of the fungus extract and hydrolysate against Aeromonas veronii, Bacillus cereus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella Typhimurium, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus dysgalactiae, and Streptococcus uberis was determined by the minimum inhibitory concentration and minimum bactericidal concentration values.

Results
The extract and its hydrolysate showed almost 100% ABTS•+ and DPPH• radical scavenging with a low half maximal inhibitory concentration. The water extract and hydrolysate of T. versicolor exhibited antimicrobial activity against two S. aureus strains, E. coli, P. aeruginosa and Salmonella Typhimurium.

Conclusion
These results provide compelling evidence that the analysed fungus extract and its hydrolysate hold promise with their antibacterial and antioxidant properties.
Transformation of the University in the Age of Artificial Intelligence: Models and Competences
Authors: Kabashkin Igor , Misnevs Boriss , Puptsau Aliaksandr 
Published: June 2023

Abstract
The article considers the possible concepts of the university of the near future considering the real emergence of special artificial intelligence applicable in the field of higher education. The authors propose a new university model (5th generation university) based on rethinking the use of the concept of competence and applied results in the field of cognitive sciences. It is proposed to revise the existing classical set of professional and social competencies, which will consider the redistribution of responsibilities in society between a person and intellectual systems. The technical readiness of society is assessed to significantly expand the scope of the use of IT technologies and free up human resources for creative activity.
On Enhanced Intelligent Water Drops Algorithm for Travelling Salesman Problem under Uncertain Paradigm
Authors: Halder Swapna , Sharma Haresh Kumar , Biswas Arindam , Prentkovskis Olegas , Majumder Saibal , Skačkauskas Paulius 
Published: June 2023

Abstract
Travelling salesman problem (TSP) is a well known combinatorial optimization problem which has drawn colossal attention due to its eclectic range of applications. In this article, we have proposed two modified versions of intelligent water drops (IWD) algorithm. The first one is the enhanced IWD (e-IWD) algorithm to solve single objective TSP. In the second modification, e-IWD algorithm has been extended to enhanced multi-objective IWD(e-MIWD) algorithm for solving multi-objective TSP. In order to achieve a better exploration capability in both of the proposed algorithms, the soil and velocity parameters of a randomly selected water drop are updated after every iteration of the algorithm when it traverses all the intermediate vertices for a tour. The proposed algorithms have been compared with some other existing similar algorithms on different benchmark instances of TSPs. Furthermore, we have addressed the TSP for both single and multiple objectives under uncertain environment.