bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized evaluation of routine beta-blocker therapy after myocardial infarction quality of life (RQoL): design and rationale of a multicentre, prospective, randomized, open, blinded endpoint study
Authors: Humphries Sophia , Mars Katarina , Hofmann Robin , Held Claes , Olsson Erik M G 
Published: April 2023

Abstract

Aims
Most cases of acute myocardial infarction (MI) in Sweden are treated with long-term β-blocker therapy as secondary prevention. Case studies and patient reports have indicated negative effects of β-blockers including symptoms of depression, fatigue, sexual dysfunction, and general low mood, all related to reduced quality of life (QoL). To date, no recent large-scale, randomized trial has explored the effects of β-blockers on these factors.

Methods and results
The ongoing Randomized Evaluation of Decreased Usage of beta-bloCkErs after myocardial infarction (REDUCE): quality of life (RQoL) study is a multicentre, prospective, randomized pre-specified substudy aiming to evaluate the effects of β-blockers on self-reported measures of QoL. Following randomized allocation to long-term β-blocker or no β-blocker treatment, patients complete a total of six baseline measures pertaining to QoL, sexual functioning, and perceived side effects. Data collection is optionally carried out online through a unique and secure portal and repeated again at two follow-up time points. Recruitment began in July 2018. Data from the first 100 patients showed that at the first follow-up, 93% had completed the questionnaires, which decreased to 81% at the second follow-up. The method of digital data collection was utilized by over half of the patients recruited so far.

Conclusion
Data from the first 100 patients indicate success in terms of study design and recruitment. The RQoL substudy investigates the effects of β-blockers on self-reported measures of QoL in MI patients and will potentially contribute to the limited knowledge of QoL-related side effects reported in conjunction with β-blocker use.

Clinical trial registration
Eudra CT number, 2017-002336-17; Clinical trial.gov identifier, NCT03278509
DMKPs provide a generalizable strategy for studying genes required for reproduction or viability in nontraditional model organisms
Authors: Laursen Willem J , Busby Rachel , Sarkissian Tatevik , Chang Elaine C , Garrity Paul A 
Published: April 2023

Abstract
The advent of CRISPR/Cas9-mediated genome editing has expanded the range of animals amenable to targeted genetic analysis. This has accelerated research in animals not traditionally studied using molecular genetics. However, studying genes essential for reproduction or survival in such animals remains challenging, as they lack the tools that aid genetic analysis in traditional genetic model organisms. We recently introduced the use of distinguishably marked knock-in pairs (DMKPs) as a strategy for rapid and reliable genotyping in such species. Here we show that DMKPs also facilitate the maintenance and study of mutations that cannot be maintained in a homozygous state, a group which includes recessive lethal and sterile mutations. Using DMKPs, we disrupt the zero population growth locus in Drosophila melanogaster and in the dengue vector mosquito Aedes aegypti. In both species, DMKPs enable the maintenance of zero population growth mutant strains and the reliable recovery of zero population growth mutant animals. Male and female gonad development is disrupted in fly and mosquito zero population growth mutants, rendering both sexes sterile. In Ae. aegypti, zero population growth mutant males remain capable of inducing a mating refractory period in wild-type females and of competing with wild-type males for mates, properties compatible with zero population growth serving as a target in mosquito population suppression strategies. DMKP is readily generalizable to other species amenable to CRISPR/Cas9-mediated gene targeting, and should facilitate the study of sterile and lethal mutations in multiple organisms not traditionally studied using molecular genetics.
Stress and coping in the face of COVID-19: a qualitative inquiry into early pandemic experiences and psychological well-being of health workers in Burkina Faso, Senegal and The Gambia
Authors: Lohmann Julia , Diallo Marème , De Allegri Manuela , Koulidiati Jean-Louis , Martinez-Alvarez Melisa 
Published: April 2023

Abstract
COVID-19 represented an unprecedented challenge for health workers around the world, resulting in strong concerns about impacts on their psychological well-being. To inform on-going support and future preparedness activities, this study documented health workers’ experiences, well-being and coping throughout the first wave of the pandemic, in Burkina Faso, Senegal and The Gambia. We collected data from 68 primarily clinical staff from the COVID-19 treatment, maternity and emergency departments in 13 purposely hospitals and laboratories across the three countries. Following in-depth interviews via Zoom (mid-May to September 2020), we regularly followed up via WhatsApp until the end of 2020. We used a mixed deductive and inductive coding approach and a framework matrix to organize and analyse the material. All respondents initially assessed the situation as stressful and threatening. Major emotional reactions included fear of own infection, fear of being a risk to loved ones, guilt, compassion, and anxiety regarding the future. Many suffered from feeling left alone with the emerging crisis and feeling unvalued and unappreciated, particularly by their governments and ministries of health. Conversely, health workers drew much strength from support and valuation by direct supervisors and team members and, in part, also by patients, friends and family. We observed important heterogeneity between places of work and individual backgrounds. Respondents coped with the situation in various ways, particularly with strategies to manage adverse emotions, to minimize infection risk, to fortify health and to find meaning in the adverse circumstances. Coping strategies were primarily grounded in own resources rather than institutional support. Over time, the situation normalized and fears diminished for most respondents. With a view towards emergency preparedness, our findings underline the value of participation and transparent communication, institutional support and routine training to foster health workers’ psychological preparedness, coping skill set and resilience more generally.
Group well-child care as a facilitator of psychoeducation: pediatrics residents’ perspectives
Authors: Nogelo Patricia Faraone , Oldfield Benjamin J , Fenick Ada M , Rosenthal Marjorie S 
Published: April 2023

Abstract
Psychoeducation, where clinicians teach problem-solving skills in a supportive environment, can help address families’ social vulnerabilities and promote well-being. Group well-child care (GWCC) may provide unique opportunities for pediatric residents to improve their skills in psychoeducation. Our aim was to characterize pediatric residents’ perspectives and experiences of communication while conducting both individual well-child care and GWCC. We used a longitudinal qualitative study design to conduct 15 semistructured interviews with five pediatric residents who facilitated GWCC. Using the constant comparative method, we characterized pediatric residents’ perspectives and experiences of communication while conducting both individual well-child care and GWCC. Four themes emerged. Residents perceived that GWCC (i) enabled families to honestly share their knowledge and parenting practices, (ii) allowed time and a space for families to share personal stories and scenarios, (iii) facilitated discussions of maternal health and psychosocial matters, toward which residents felt ambivalence, and (iv) fostered skills in psychoeducation that transferred to the rest of their clinical practice. When pediatric residents lead GWCC, they perceive that they can facilitate key aspects of psychoeducation, enabling them to assist families in meeting complex social needs. Residents describe that they transfer psychoeducation skills learned in GWCC to the rest of their practice.
The psychosocial outcomes of older parenthood in early to mid-childhood: a mini-review
Authors: Lysons Joanna , Jadva Vasanti 
Published: April 2023

Abstract
Recent decades have seen a global trend towards delaying parenthood, referred to as the ‘postponement transition’. Whilst there is plentiful research regarding obstetric and paediatric outcomes related to delayed parenthood, relatively little is known about the psychosocial outcomes associated with advanced parental age during early and middle childhood. This mini-review examines the current literature regarding the psychosocial functioning of families headed by older parents. First, we give an overview of the literature that examines the psychological wellbeing of older first-time parents. We then review the literature regarding the quality of the parent–child relationship in older parent families. Finally, we discuss the psychosocial adjustment and cognitive development of children of older parents. We conclude with suggestions for future research avenues.
Political Elite Discourses and Majority Members’ Beliefs About the Prevalence of Ethnic Discrimination in Europe
Authors: Müller Katrin , Blommaert Lieselotte , Savelkoul Michael , Lubbers Marcel , Scheepers Peer 
Published: April 2023

AbstractThis article investigates European majority members’ perceptions of the prevalence of ethnic discrimination. We use individual-level data from the Eurobarometer ‘Discrimination in the EU’ series, covering 26 European countries and six years (2006, 2008, 2009, 2012, 2015, and 2019), enriched with contextual information on political elite discourses from the Comparative Manifesto Project. We shed light on significant and substantive cross-country and cross-temporal variations in these perceptions. Next, we explore how these variations are related to national political elite discourses by employing multilevel models. By disentangling between and within country variations, we find that particularly changes in political elite discourses within countries over time are associated with variations in majority members’ beliefs about the prevalence of ethnic discrimination in their society. Exclusive discourses, which emphasize nationalistic ideas and demarcate strong boundaries between ethnic groups, are associated with majority members thinking that ethnic discrimination is less widespread in their country. The reverse holds for inclusive discourses: when political elites underline the importance of cultural diversity and multiculturalism, majorities perceive more ethnic discrimination. While these discourses are only related to within country variations, our descriptive and multilevel results show that the national context matters for majorities’ perceptions of the prevalence of ethnic discrimination.
Diagnostics of ovarian cancer via metabolite analysis and machine learning
Authors: Yao Jerry Z , Tsigelny Igor F , Kesari Santosh , Kouznetsova Valentina L 
Published: April 2023

AbstractOvarian cancer (OC) is the second most common cancer of the female reproductive system. Due to the asymptomatic nature of early stages of OC and an increasingly poor prognosis in later stages, methods of screening for OC are much desired. Furthermore, screening and diagnosis processes, in order to justify use on asymptomatic patients, must be convenient and non-invasive. Recent developments in machine-learning technologies have made this possible via techniques in the field of metabolomics. The objective of this research was to use existing metabolomics data on OC and various analytic methods to develop a machine-learning model for the classification of potentially OC-related metabolite biomarkers. Pathway analysis and metabolite-set enrichment analysis were performed on gathered metabolite sets. Quantitative molecular descriptors were then used with various machine-learning classifiers for the diagnostics of OC using related metabolites. We elucidated that the metabolites associated with OC used for machine-learning models are involved in five metabolic pathways linked to OC: Nicotinate and Nicotinamide Metabolism, Glycolysis/Gluconeogenesis, Aminoacyl-tRNA Biosynthesis, Valine, Leucine and Isoleucine Biosynthesis, and Alanine, Aspartate and Glutamate Metabolism. Several classification models for the identification of OC using related metabolites were created and their accuracies were confirmed through testing with 10-fold cross-validation. The most accurate model was able to achieve 85.29% accuracy. The elucidation of biological pathways specific to OC using metabolic data and the observation of changes in these pathways in patients have the potential to contribute to the development of screening techniques for OC. Our results demonstrate the possibility of development of the machine-learning models for OC diagnostics using metabolomics data.
Meningitis caused by extended-spectrum β-lactamase-producingEscherichia coliin infants in France: a case series
Authors: Lignieres Gabriel , Rybak Alexis , Levy Corinne , Birgy André , Bechet Stéphane , Bonacorsi Stéphane , Cohen Robert , Madhi Fouad 
Published: April 2023

AbstractObjectivesWe report the first case series focusing on clinical and biological characteristics of meningitis caused by ESBL-producing Escherichia coli in infants.MethodsBetween 2001 and 2020, data on all cases of E. coli meningitis were prospectively collected from a network of 259 paediatric wards and 168 microbiology laboratories in France. We analysed the clinical and biological characteristics, short-term complications and long-term sequelae of ESBL-producing E. coli meningitis cases in patients &lt;6 months old.ResultsIn total, 548 cases of E. coli paediatric meningitis were reported. ESBL-producing E. coli represented 12 (2.2%) cases. We included 10 patients aged &lt;6 months old. Eight (80%) patients presented at least one sign of clinical severity: six needed mechanical ventilation, three presented signs of shock and one was in a coma. The overall short-term prognosis was good, with only one meningitis-attributed death in the first hours of care. All surviving children received carbapenems for a median of 21 days (range 9–28). Two relapses occurred, including one in a patient who received only 14 days of imipenem. We reported no long-term sequelae at a median follow-up of 20 months.ConclusionsMeropenem seems to be the treatment of choice for ESBL-producing E. coli meningitis in children and needs to be given as early as possible (&lt;48 h) and for at least 21 days. Maternal colonization or infection with ESBL-producing Enterobacteriaceae needs to be reported to the neonatal or paediatric ICU team, in order to adapt the empirical antibiotic therapy.
Use of the electronic medical record to screen for high-risk geriatric patients in the emergency department
Authors: Saxena Saket , Meldon Stephen , Hashmi Ardeshir Z , Muir McKinsey , Ruwe Jeffrey 
Published: April 2023

AbstractOlder adults with multimorbidities have the highest rate of emergency department (ED) usage. These patients are typically on numerous medications, may have underlying dementia, and often present with falls and delirium. Identifying these high-risk older adults for possible intervention is challenging in the ED setting since available screening methods are manual and resource-intensive. The objective is to study the electronic medical record (EMR) use for identifying high-risk older adults in ED. This feasibility study is conducted in an academic ED with 67 000 total and 24% geriatric (age ≥ 65 years) annual visits, American College of Emergency Physician (ACEP) accredited Level 1 Geriatric Emergency Department with an ED-based geriatric consultation program by incorporating criteria from existing manual geriatric screening instruments and the 4M framework into an automated EMR screen to identify high-risk geriatric patients. ED providers are then alerted by an EMR Best Practice Alert (BPA) if high-risk status is identified. Initial development and impact on geriatric ED consults are reported. During the study period, 7450 patient encounters occurred; 1836 (24.6%) encounters involved patients who were 65 years or older. A total of 1398 (76.1%) high-risk ED encounters resulted in BPA alerts using the EMR automated screen. BPA alerts resulted in 82 (5.9%) geriatric evaluations. We conclude that using the EMR to automate screening for older adults for high-risk geriatric conditions in the ED is feasible. An automated EMR screen with a BPA to ED providers identified a well-defined cohort of older patients appropriate for further ED geriatric evaluation.
Lethal and sublethal effects of toxic bait formulations on Doryctobracon areolatus (Hymenoptera: Braconidae) and implications for integrated fruit fly management
Authors: Piovesan Bruna , Contreras Miranda Javier Antonio , Gonçalves Rafael da Silva , Daniel Nörnberg Sandro , Bernardi Daniel , Botton Marcos , Nava Dori Edson 
Published: April 2023

Abstract
The use of toxic baits has become one of the main methods of management of fruit flies in Brazil. The application of toxic baits may cause side effects on the native parasitoid Doryctobracon areolatus (Hymenoptera: Braconidae). Based on the results, formulations made from the food attractants 3% Biofruit, 1.5% Ceratrap, 1.25% Flyral, 3% Isca Samaritá, 3% Isca Samaritá Tradicional, and 7% sugarcane molasses associated with the Malathion 1000 EC and the ready-to-use toxic bait Gelsura (containing the active ingredient alpha-cypermethrin) were classified as harmful (class 4) to D. areolatus (mortality &gt; 85% at 96 HAE). In contrast, for toxic baits formulated with insecticide phosmet, the mortality ranged from 38% to 72%, classified as slightly harmful or moderately harmful. However, when phosmet was added to the 3% Samaritá Tradicional bait, the mortality was only 3.9% (class 1—harmless), similar to the toxicity observed for the Success 0.02 CB ready-to-use bait (0.24 g a.i. spinosad/l) (&lt;5% mortality). Although toxic baits were formulated with spinosyn-based insecticides, all toxic bait formulations were classified as harmless or slightly harmful (&lt;50% mortality) to D. areolatus, with the exception of 1.5% Ceratrap + spinetoram and 7% Sugarcane molasses + spinosad (≈ 60% mortality—moderately harmful). In addition, these formulations did not show sublethal effects in reducing the parasitism and emergence rate of the F1 generation of D. areolatus in A. fraterculus larvae. The results serve as a basis for the correct use of toxic food baits without affecting the biological control.
Legal Dilemmas of Climate Action
Authors: Bogojević Sanja 
Published: April 2023

Abstract
How we frame environmental problems and their solutions matters. Under the UK Net Zero Strategy and the European Green Deal, climate action—as a policy- and regulatory response to climate change—is framed overwhelmingly positive and coupled with the ambitions to generate growth, facilitate innovation, improve health and wellbeing, ensure inclusiveness and much else. This is done to project climate ambitions as part of a win–win scenario where no one is left behind. Yet it is unclear how each of the different aims relate to each other, which risks creating legal dilemmas, and possibly undermining climate action altogether.
Where are the Voices and Experiences of Persons with Disabilities/Disabled People in Transitional Justice Research and Practice?
Authors: Clark Janine Natalya 
Published: April 2023

Abstract
The ever-expanding field of transitional justice has, to date, largely overlooked the issue of disability, even though there is growing research on disability and armed conflict. Relatedly, little attention has been given to the accessibility of transitional justice processes. This Policy and Practice Note, the idea for which developed from the author’s own personal experiences and reflections as a transitional justice scholar with a physical disability, points to unexplored synergies between the human rights and social models of disability (reflected within the UN Convention on the Rights of Persons with Disabilities), on one hand, and transitional justice, on the other. It also highlights and discusses three important dimensions of accessibility—processual, contextual and methodological—that could be usefully explored within transitional justice scholarship and practice to give the issue of disability the recognition and prominence that it deserves.
CD200Fc limits dendritic cell and B-cell activation during chronic allergen exposures
Authors: Patoine Dany , Bouchard Karine , Blais-Lecours Pascale , Courtemanche Olivier , Huppé Carole-Ann , Marsolais David , Bissonnette Elyse Y , Lauzon-Joset Jean-Francois 
Published: April 2023

Abstract
Allergic asthma is a chronic inflammatory disease characterized by Th2, conventional dendritic cell, and B-cell activation. In addition to excessive inflammation, asthma pathogenesis includes dysregulation of anti-inflammatory pathways, such as the CD200/CD200R pathway. Thus, we investigated whether a CD200R agonist, CD200Fc, could disrupt the inflammatory cascade in chronic allergic asthma pathogenesis using a mice model of experimental asthma. Mice were exposed to house dust mites for 5 wk, and CD200Fc treatment was initiated after chronic inflammation was established (starting on week 4). We demonstrate that chronic house dust mite exposure altered CD200 and CD200R expression on lung immune cell populations, including upregulation of CD200 on alveolar macrophages and reduced expression of CD200 on conventional dendritic cells. CD200Fc treatment does not change bronchoalveolar cellular infiltration, but it attenuates B-cell activation and skews the circulating immunoglobulin profile toward IgG2a. This is accompanied by reduced activation of conventional dendritic cells, including lower expression of CD40, especially on conventional dendritic cell subset 2 CD200R+. Furthermore, we confirm that CD200Fc can directly modulate conventional dendritic cell activation in vitro using bone marrow–derived dendritic cells. Thus, the CD200/CD200R pathway is dysregulated during chronic asthma pathogenesis, and the CD200R agonist modulates B-cell and dendritic cell activation but, in our chronic model, is not sufficient to alter inflammation measured in bronchoalveolar lavage.
Particle beam therapy versus photon radiotherapy for extrahepatic biliary cancer—systemic review and meta-analysis
Authors: Yamazaki Hideya , Kimoto Takuya , Teramukai Satoshi , Fujikawa Kei , Shibuya Kei , Suzuki Motohisa , Terashima Kazuki , Iizumi Takashi , Wakatsuki Masaru , Suzuki Osamu , Fukumoto Takumi , Ohtsuka Masayuki 
Published: April 2023

Abstract
Particle beam therapy (PT) is a potentially promising approach to the treatment of extrahepatic biliary cancer (EBC) because of its unique dose distribution using the Bragg peak. However, the superiority of PT to photon radiotherapy (XT) remains unclear. Therefore, we conducted a systematic review and meta-analysis to compare PT and XT for the treatment of EBC. The primary endpoint was overall survival (OS), which was pooled using a random-effects model. Nine articles comprising a total of 1558 patients (seven XT articles, n = 1488 patients; two PT articles, n = 70 patients) were screened. In addition, we compared the outcomes of XT and PT with the outcomes available from a prospective data registry (proton-net). The 1-year OS probability rates were 55, 65 and 72% for the XT group, PT group and PT registry, respectively. The 2-year OS probability rates were 26, 38 and 38% for the XT group, PT group and PT registry, respectively. The 3-year OS probability rates were 12, 35 and 18% for the XT group, PT group and PT registry, respectively. Although the difference between the 1-year OS rates of the XT group and PT registry was statistically significant, no other significant superiority was observed among these groups. In conclusion, the efficacy of PT was not superior to that of XT during this meta-analysis.