bluuebunny/crossref_metadata_2025_split huggingface dataset:
Winter rye cultivars moderately resistant to ergot
Authors: Shchekleina L. M. , Sheshegova T. K. 
Published: December 2022

Background. Cereal ergot caused by the fungus Claviceps purpurea (Fr.) Tul. is a progressive disease of winter rye. There are no rye cultivars resistant to the disease, and breeding methods of protection have not been developed in Russia.Materials and methods. The material for the research included 97 winter rye cultivars. A biochemical analysis of the sclerotia of the fungus was carried out, the composition and content of ergot alkaloids (EA) in the sclerotia of C. purpurea from the Kirov population were studied, and the relationship between the biometry of sclerotia and the EA content, toxicity and pathogenicity of C. purpurea was analyzed. Well-known methods of resistance assessment and EA analysis were applied.Results and conclusions. Fourteen cultivars least affected by the pathogen were identified: ‘Flora’, ‘Kiprez’, ‘Grafinya’, ‘Lika’, ‘Batist’, ‘Simfoniya’, ‘Garmoniya’, ‘Sadko’, ‘Parom’, ‘Virazh’, ‘Saratovskaya 7’, ‘Volkhova’, ‘Novaya Era’, and ‘Podarok’. They can be used in breeding for ergot resistance. Three types of EA were identified in C. purpurea sclerotia: ergocristine, ergotamine, and its stereoisomer ergocristinine. Cvs. ‘Lika’, ‘Simfoniya’ and ‘Garmoniya’ were the least affected by ergot, and the sclerotia formed on the plants of these cultivars did not accumulate EA. A significant (r = 0.50–0.60) correlation was found between lesions and biometric parameters of C. purpurea sclerotia, and between grain contamination with sclerotia and their biometrics (r = 0.63– 0.78). A weak positive correlation (r = 0.22) was detected between the toxicity and pathogenicity of C. purpurea. A negative correlation was established between the weight of sclerotia and the accumulation of EA in them (r = –0.46), which indicated the biological danger of small sclerotia that got into the seed and food batches of grain.
The Current Development of Marriage Age Provisions in Indonesia and Malaysia: A Socio-Historical Approach
Authors: Turnip Ibnu Radwan Siddik , Fuad Zainul , Nurhayati Nurhayati 
Published: December 2022

This paper discusses how the current social history of Islamic law in the Southeast Asian region relates to the minimum age of marriage. Then also, it will be examined how socio-cultural and socio-political influences surround the change in the provisions of the minimum age of marriage in the two countries. This normative legal research focused on studying legal history using the social history approach of Islamic law. Data is analyzed with qualitative methods. The results showed a change in the age of marriage in Indonesia, from 19 years for men and 16 years for women to 19 years for both men and women. While in Malaysia, most states have not changed the minimum age of marriage, remaining at 18 years old for men and 16 years for women. The change in the age of marriage occurs in the state of Selangor alone, which determines the marriage age limit is 18 years for men and women. The difference in terms of the marriage age limit in these two countries is strongly influenced by the socio-cultural and socio-political dynamics in society. The aspirations of some groups of people towa Â rds changing the marriage age limit in both countries have also strengthened due to the growing number of cases of child marriage, extramarital pregnancy, and the practice of abortion in both countries.
Estudio de los pacientes con elevación de enzima Creatinfosfokinasa en dos hospitales de tercer nivel de la ciudad de córdoba
Authors: Saad Emanuel José , Rodríguez Ruiz Andrés , Douthat y Barrionuevo Augusto , Milanesio Martín , Flores Balverdi Janet , Riscanevo Nadia Claudine , Peñaranda Gabriela Estefanía , Novatti Elisa Beatriz , Saurit Verónica , Alvarez Ana Cecilia , Baenas Diego Federico 
Published: December 2022

Introducción: Se denomina hiperCKemia a la elevación de niveles de creatinfosfoquinasa (CK) mayor a 1,5 veces el límite superior(CK>285 U/L), siendo producida por múltiples causas, que varían según las poblaciones de estudio. El objetivo principal del estudio fue conocer la frecuencia de hiperCKemia en dos hospitales de la Ciudad de Córdoba y sus principales causas.
Metodología: Estudio analítico retrospectivo en dos hospitales de la ciudad de Córdoba en Argentina, donde se identificaron todos los pacientes mayores de 18 años que presentaron valores de CK mayores a 285 U/L en al menos 2 oportunidades en un período entre 1 y 4 semanas, entre los años 2015 y 2017.
Resultados: Se identificaron 254 pacientes con hiperCKemia, la mayoría eran de sexo masculino (n=181, 71.3%) y su mediana de edad fue 65 años (rango intercuartil 25-75%=50-73 años). Las principales causas de hiperCKemia fueron la miopatía isquémica en 99 (39%) pacientes y las miopatías inducidas por drogas en 45 (17.7%), siendo las estatinas las drogas más frecuentemente involucradas en 31 casos. En sólo el 3.1% de los casos no se arribó al diagnóstico final. Las hiperCKemias inducidas por drogas al compararse con las otras causas, se presentaron más frecuentemente en pacientes con antecedente de enfermedad renal crónica (9/45[20%] vs 18/209[8.6%], p=0.025) y en no tabaquistas(41/45[91.1%] vs 157/209[75.1%], p=0.019) .
Conclusión: Se observaron 254 casos de hiperCKemia, siendo sus principales causas de origen isquémico y secundario a consumo de fármacos, especialmente por estatinas.
Klasifikasi Sentimen Tweet Mengenai Covid-19 Pada Twitter Di Indonesia Dengan Metode Vector Space Model
Authors: Harlina Sitti , Lillikwatil Rudy Donny , Aryasa Komang , Susanto Cucut , Sapriadi Sapriadi , Alfriady Edwin Tri 
Published: December 2022

Berdasarkan laporan dari Direktur Jenderal Sumber Daya Perangkat Pos dan Informatika (SDPP) Kementerian Komunikasi dan Informatika Tahun 2019 Indonesia menjadi negara yang menduduki peringkat 8 dalam mengakses situs Twitter, Pandemi corona virus saat ini membuat seluruh sendi kehidupan berubah, salah satunya yaitu proses belajar mengajar yang harus dilakukan dari rumah, di Indonesia pendapat mengenai corona virus masih beragam. Pada penelitian ini data yang dipakai adalah data percakapan digital di media sosial twitter yang menjadi objek dari penelitian ini. Penelitian ini menggunakan jenis penelitian eksperimental yang berarti mencoba, mencari, dan mengkonfirmasi data pada percakapan di twitter mengenai Covid-19 yang di klasifikasi dengan metode Vector Space Model, telah berhasil dan sesuai dengan spesifikasi yang diinginkan, Metode Vector Space Model untuk mengklasifikasi tweet mengenai Covid-19, dapat di impelemntasikan dengan hasil tweet yang memperlihatkan nilai positif dengan 52,1%. Sistem dapat menjadikan program ini digunakan untuk menganalisa penentuan terhadap data tweet pada tahun berjalan. Pengembangan dapat dilakukan dengan mengimplementasikan pengunaan metode lain dalam mengklasifikasi data twitter.Untuk menyempurnakan sistem ini, dapat mengembangkan sistem yang dapat digunakan oleh perangkat mobile.
Analisis Sentimen Masyarakat Terhadap Exchange Tokocrypto Pada Twitter Menggunakan Metode LSTM
Authors: Sandag Green Arther , Waworundeng Jacquline 
Published: December 2022

Internet telah berperan penting dalam mempengaruhi semua aktivitas manusia di era teknologi saat ini. Dengan adanya internet dapat digunakan untuk berbagai tujuan, termasuk berbagi pengetahuan, bertransaksi, bersosialisasi, berbelanja, bisnis, pendidikan, dan banyak hal lain yang dapat dilakukan. Sementara internet semakin populer, berbagai macam transaksi digital terus berkembang, salah satunya yaitu pertukaran koin ke koin lain yang disebut cryptocurrency (mata uang kripto). Cryptocurrency adalah aset digital yang menggunakan kriptografi yang kuat untuk mengenkripsi transaksi keuangan, dan memverifikasi transfer aset. Salah satu exchange cryptocurrency untuk investasi di Indonesia yaitu Tokocrypto. Dengan begitu ramainya antusias dari cryptocurrency, banyak masyarakat Indonesia menggunakan media sosial seperti Twitter untuk mencari informasi, memberikan pendapat, juga informasi. Untuk mengklasifikasi tweet publik di Twitter ke dalam kategori positif dan negatif, diperlukan model analisis sentiment. Penelitian ini menggunakan metode Long Short Term Memory (LSTM), dimana LSTM merupakan salah satu pengembangan neural network yang dapat digunakan untuk pemodelan data time series terhadap tweet pengguna Twitter terhadap exchange Tokocrypto. Didapatkan sebanyak 2022 tweets positif, 1632 tweets negative, dan 1012 tweets netral.
Kata kunci—Internet, Mata Uang Kripto, Investasi, Pertukaran, Tokocrypto, LSTM
Vitamin D and Ophthalmolopathies. A Review
Authors: Paulína Hribová , Sotak Štefan 
Published: December 2022

The importance of vitamin D3 (hydroxycholecalciferol) as one of the liposoluble vitamins is known in the prevention and treatment of metabolic bone diseases (rickets, osteomalacia, osteoporosis). In recent years, however, information has increased on the importance of vitamin D3 in numerous organ systems and in the pathogenesis of various diseases, e. g. ophthalmopathies. The immunological functions of vitamin D3 are the subject of studies dealing with autoimmune optic nerve disorders and their results appear to have a positive effect on demyelinating diseases. It also plays an important role in maintaining the thickness of the retinal nerve fiber layer, but its additional administration has not been successful. Optical neuritis may be the first sign of multiple sclerosis. It appears that sufficient serum vitamin D3 levels may protect patients from deterioration in the form of a further attack of demyelination. The course of diabetic retinopathy is probably also influenced by vitamin D3, inter alia, by correlating the fact that its receptor and the enzymes of its metabolism are expressed on the retina. Low serum levels of vitamin D3 may even trigger age-related macular degeneration. Conversely, higher dietary intake of vitamin D3 may positively affect neovascularization. The optimal level of hydroxycholecalciferol is between 60 and 200 nmol /l, the severe deficit represents a decrease below 25 nmol/l. The body can normally produce up to 10,000 IU of this vitamin after exposure to sunlight. However, the demonstration of its protective character in connection with the mentioned diseases of the retina and optic nerve will require a sufficient number of studies to confirm the facts found so far about this rediscovered vitamin.
Tube Versus Trabeculectomy in Juvenile-Onset Open Angle Glaucoma – Treatment Outcomes in Tertiary Hospitals In Malaysia
Authors: Bin Mohd Rasidin Abd Hadi , Ang Wen Jeat , Raja Norliza Raja Omar , Husain Norhalwani Binti , Azhany Yaakub , Liza-Sharmini Ahmad Tajudin 
Published: December 2022

Aim of the study: To compare the intraocular pressure (IOP) lowering effect and postoperative complications between primary augmented trabeculectomy and glaucoma drainage device (GDD) implantation as primary surgical intervention in patients with juvenile-onset open angle glaucoma (JOAG).
Patients and Methods: A retrospective review study involving 20 eyes that underwent primary augmented trabeculectomy with mitomycin (MMC) and 10 eyes GDD implantation in 3 tertiary centres in Malaysia between 1 January 2013 and 31 December 2019. They were followed up for at least 12 months postsurgical intervention. Intraocular pressure (IOP), number of topical IOP lowering medication and complications were evaluated at 1, 3, 6 and 12 months post-intervention. Based on the IOP, the success was divided into complete and partial success, and failure. IOP and postsurgical complications were compared using the Repetitive Measure Analysis of Variance (RM ANOVA) and the Pearson chi-square test.
Results: Both methods were effective in lowering the IOP. Eyes with primary augmented trabeculectomy have significant lower IOP compared to GDD implantation (p = 0.037). There was a higher incidence of postoperative hypotony (30%) in the trabeculectomy group. There was also a significant reduction of mean number of topical pressure-lowering drugs required postoperatively (p = 0.015). Complete success was achieved in 100% of eyes with trabeculectomy and 67% in GDD implantation (p = 0.047).
Conclusions: Primary augmented trabeculectomy and GDD implantation are good surgical options for the treatment of JOAG. Both methods provide IOP lowering at 1 year. However, trabeculectomy provides better pressure lowering, compared to GDD implantation in patients with JOAG.
Assessment of Corneal Endothelial Layer in Contact Lens Wearers with the Aid of an Endothelial Microscope
Authors: Veselý Petr , Beneš Pavel , Sokolová Šidlová Jana , Záděrová Petra , Došková Hana 
Published: December 2022

Aims: The main aim of our study was to demonstrate the difference in endothelial cell density between a group of keratoconus contact lens users and non-contact lens users (without keratoconus).
Material and methods: In our study we had data from 96 subjects with an average age of 40.5 ±14.05 years. For the purposes of our study, we worked with each eye separately for each subject (n = 192). Keratoconus (research group) was diagnosed in 97 eyes. The mean age of the patients in the research group was 41.9 ±10.6 years. Keratoconus was not diagnosed in the remaining 95 eyes (control group). The mean age of the patients in the control group was 39.5 ±16.6 years. In the keratoconus group, the patients wore hard contact lenses (HCL) in a total of 43 eyes, hybrid contact lenses (HbCL) in 48 eyes and soft contact lenses (SCL) in 6 eyes. The average total period of contact lens use in the research group was 10.6 ±2.36 years.
Results: The average number of endothelial cells in the research group was 2607.11 ±298.45 cells per mm2. The average number of endothelial cells in the control group was 2831.94 ±523.51 cells per mm2. We tested these two variables using a T-test, which showed a statistically significant difference (p < 0.001). A statistically significant difference in the mean endothelial cell count related to patient age and use / non-use of contact lenses of two types was demonstrated only in the under-40 group in a comparison of the non-contact and keratoconus group with the keratoconus group using HCL
(p = 0.02). A statistically significant difference in the length of contact lens wear was demonstrated between the keratoconus-free group with or without SCL and the keratoconus group when wearing HCL or HbCL for more than 20 years (p = 0.01 and p = 0.02). For HbCL users, this difference was demonstrated also after 15 years of wearing (p = 0.001).
Conclusion: From our results we can conclude that there is a difference in endothelial cell density between patients with and without keratoconus.
INCUBAÇÃO DE CALCÁRIO FINAMENTE MOÍDO E CARACTERÍSTICAS QUÍMICAS DO SOLO SOB CULTIVO DE SOJA E MILHO
Authors: Lange Anderson , Zambiasi Júnior Mauro José , Cavalli Edilson , Pereira Cassiano Spaziani , Freddi Onã da Silva 
Published: December 2022

Estudou-se as modificações químicas no solo e o comportamento da soja e do milho decorrente da aplicação de doses de calcário calcítico e dolomítico finamente moído. O experimento ocorreu em vasos de 10 dm³ em esquema fatorial 2x4 com quatro repetições, cujos tratamentos consistiram em dois calcários (calcítico e dolomítico) e quatro doses: 0,0; 3,0; 6,0; 9,0 t ha-1. O solo foi incubado e amostrado aos 90, 200 e 300 dias. Aos 90 dias de incubação semeou-se a soja e colhida no final do ciclo. Em sequência semeou-se o milho, o qual também foi colhido. Os resultados mostraram que as doses crescentes de calcário influenciaram todas as variáveis do solo e das plantas com efeito linear ou quadrático; os teores de cálcio, magnésio, suas saturações na CTC e a relação Ca:Mg foram afetadas em função do maior teor de cada nutriente no respectivo corretivo e a aplicação de calcário finamente moído elevou saturação de bases para valores próximos do valor calculado nas menores doses, não chegando ao valor desejado apenas na dose de 9,0 t ha-1, atingindo o pico de reação aos 90 dias, decaindo a partir desta data
Palavras-chave: incubação; calcário; reatividade; PRNT.

Incubation of finely ground limestone and soil chemical characteristics under cultivation of soy and corn

ABSTRACT: The chemical changes in the soil and the behavior of soybean and corn resulting from the application of doses of finely ground calcitic and dolomitic limestone were studied. The experiment was carried out in 10 dm³ pots in a 2x4 factorial scheme with four replications, whose treatments consisted of two limestones (calcitic and dolomitic) and four doses: 0.0; 3.0; 6.0; 9.0 t ha-1. The soil was incubated and sampled at 90, 200 and 300 days. At 90 days of incubation, the soybean was sown and harvested at the end of the cycle. Next, corn was sown, which was also harvested. The results showed that the increasing doses of lime influenced all soil and plant variables with a linear or quadratic effect; the levels of calcium, magnesium, their CEC saturations and the Ca:Mg ratio were affected due to the higher content of each nutrient in the respective corrective and the application of finely ground limestone increased base saturation to values ​​close to the value calculated at the lowest doses. , not reaching the desired value only at the dose of 9.0 t ha-1, reaching the reaction peak at 90 days, decreasing from this date.
Keywords: incubation; limestone; reactivity; PRNT.
COVID-19 clinical outcomes and risk factors in fully vaccinated hemodialysis patients: A single-center prospective cohort study
Authors: Rysyev A. , Poperechnyi I. , Chernianu D. , Filonov V. , Pyankovskyi S. , Khyzhuna A. 
Published: December 2022

Hemodialysis patients (HD) are at high risk for coronavirus infection (COVID-19) and associated adverse outcomes compared with the general population. Although vaccination against SARS-CoV-2 has played an important role in stemming the spread of COVID-19 in the general population, the characterization of vaccine efficacy in dialysis patients is based primarily on humoral responses, whereas clinical data are generally not available. The aim of this study was to determine the incidence of COVID-19, clinical outcomes, and risk factors for SARS-CoV-2 infection in fully vaccinated HD patients.
Methods. Of 186 HD patients treated at Link-Medital LLC Medical Center (Odesa, Ukraine) between March 2020 and March 2022, 170 patients aged 53.5 (44-63.5) years were enrolled in this prospective observational cohort study and followed up one year after completion of vaccination. Among them were 67 (39.4%) HD patients who were fully vaccinated against COVID-19 with BNT162b2 (Pfizer-BioNTech) or Moderna-mRNA-1273 mRNA vaccines and 103 (60.6%) unvaccinated HD patients. The outcomes assessed were COVID-19 morbidity and severity, hospitalization, and death associated with COVID-19.
Results. During the 12-month follow-up, nearly half of 83/170 (48.8%) patients became infected with SARS-CoV-2, including 18/67 (26.7%) vaccinated patients and 65/103 (63.1%) unvaccinated patients (χ2 = 10.8; p = 0.001). The incidence rate of COVID-19 was 27 (95% CI 16, 42) in vaccinated patients at our center and 63 (95% CI 49, 80) per 100 patient-years (p = 0.001) in unvaccinated patients.
Cox proportional hazards regression analysis showed that vaccinated HD patients had a statistically significant lower risk of hospitalization [HR = 0.2 (95%CI 0.1;0.4)] and need for oxygen support [HR = 0.19 (95%CI 0.09; 0.38)] compared with unvaccinated patients. Kaplan-Meyer analysis of COVID-19-associated mortality demonstrated a significantly higher survival of vaccinated HD patients compared with unvaccinated (χ2 = 4.6, log-rank p = 0.03).
Further multivariate logistic analysis showed that age over 65 years, obesity, low adequacy of HD and duration of more than 5 years, anemia, low levels of parathyroid hormone (PTH) and high-density lipoprotein cholesterol (HDL-C), elevated CRP, arterial hypertension, and other cardiovascular diseases (CVD) significantly increased the risk of SARS-CoV-2 infection in fully vaccinated HD patients.
Conclusions. Vaccination against COVID-19 is associated with a reduction in morbidity, hospitalization rates, and mortality in HD patients. Age over 65 years, obesity, low adequacy of HD and its duration of more than 5 years, anemia, low PTH and HDL-C levels, elevated CRP, arterial hypertension, and other CVDs significantly increased the risk of SARS-CoV-2 infection in fully vaccinated HD patients.
Stosowanie przez inspekcję farmaceutyczną art. 99 ust. 4 ustawy Prawo farmaceutyczne do zezwoleń na prowadzenie aptek ogólnodostępnych wydanych przed wejściem w życie ustawy „apteka dla aptekarza”
Authors: Rabiega-Przyłęcka Agnieszka 
Published: December 2022

W artykule przedstawiono problemy ze stosowaniem przez inspekcję farmaceutyczną ustawy z dnia 7 kwietnia 2017 r. o zmianie ustawy Prawo farmaceutyczne (zwanej ustawą „Apteka dla Aptekarza”) wprowadzającej wymóg udzielania zezwoleń na prowadzenie aptek ogólnodostępnych farmaceutom albo spółkom osobowym tworzonym przez farmaceutów do zezwoleń na prowadzenie aptek ogólnodostępnych wydanych przed wejściem w życie tej ustawy. Przyjęta przez organy inspekcji farmaceutycznej interpretacja, że podmiot, występując o zmianę zezwolenia na prowadzenie apteki, które uzyskał przed wejściem w życie ustawy nowelizującej, musi spełniać wszystkie nałożone obecnie obowiązującymi przepisami ustawy Prawo farmaceutyczne wymogi jakie musi spełnić podmiot ubiegający się o udzielenie takiego zezwolenia budzi wątpliwości, co potwierdził także Naczelny Sąd Administracyjny w wyrokach z 24 lutego 2022 r. (sygn. II GSK 384/20, II GSK 477/20). Celem artykułu jest przedstawienie problemów związanych ze stosowaniem ustawy „Apteka dla Aptekarza” i podjęcie polemiki z budzącą wątpliwości interpretacją tych przepisów przyjętą przez inspekcję farmaceutyczną. W artykule podniesiono argumentację przemawiającą za niedopuszczalnością stosowania normy wynikającej ze znowelizowanego art. 99 ust. 4 ustawy Prawo farmaceutyczne do zezwoleń na prowadzenie aptek ogólnodostępnych, które zostały udzielone pod wejściem w życie nowelizacji.
Trudności w rozstrzyganiu przez samorządowe kolegia odwoławcze spraw w przedmiocie świadczeń pielęgnacyjnych, związane z brakiem jednolitości orzeczniczej sądów administracyjnych – wybrane zagadnienia
Authors: Oleksy-Piesik Izabela 
Published: December 2022

Świadczenie pielęgnacyjne jest formą wsparcia przez Państwo osób, które rezygnują z zatrudnienia ze względu na konieczność sprawowania opieki nad niepełnosprawnym członkiem rodziny. Jego rolą jest zrekompensowanie osobie zdolnej do pracy utraty wynagrodzenia. Nie jest to jednak jedyne świadczenie tego rodzaju. Fakt występowania kilku świadczeń, przyznawanych w oparciu o takie same przesłanki, lecz w różnych wysokościach jest sytuacją niekorzystną.Trudności orzecznicze organów administracji publicznej, pojawiające się na gruncie widocznej tu kolizji świadczeń, sprowadzają się do konieczności wypracowania takiego rozwiązania prawnego, które w najpełniejszy sposób zagwarantuje stronie prawo wyboru świadczenia dla niej najkorzystniejszego. Wskazówek w tym zakresie poszukuje się przede wszystkim w orzecznictwie sądowoadministracyjnym. Prezentowanych jest tam kilka - niestety - wykluczających się stanowisk. Każde z nich ma zarówno wady jak i zalety. Celem opracowanie jest ukazanie jak: niejednolitość orzecznicza, zmienność prezentowanych przez sądy poglądów, a także brak jednoznacznych wskazówek, co do dalszego postępowania w danej sprawie wpływa na praktykę stosowania prawa. O tym, że jest to realny problem dla organów administracji publicznej, w szczególności samorządowych kolegiów odwoławczych, świadczy już tylko ilość rozpatrywanych spraw tego rodzaju.Widoczna na tym gruncie dynamika orzecznictwa sądów administracyjnych przekłada się na działania organów właściwych w sprawach świadczeń pielęgnacyjnych. Przede wszystkim, prowadzi zaś do sytuacji, w której brak jest możliwości uszanowania postulatu zachowania ”utrwalonej praktyki rozstrzygania spraw w takim samym stanie faktycznym i prawnym”. Sprowadza się to do tego, że w podobnych sprawach, wydawane są różne rozstrzygnięcia.