bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicochemical assessment and insilico studies on the interaction of 5-HT2c receptor with herbal medication bioactive compounds used in the treatment of premature ejaculation
Authors: Aghanwa Charles I. , Ekpunobi Uche E. , Ogbuagu Adaora 
Published: February 2023

Abstract
Premature ejaculation (PE) affects one in every four men around the world, and there is no known cure for this sexual dysfunction. Many non-herbal and herbal medications are prescribed for their treatment, some of which have not been thoroughly evaluated for their efficacy and role in the body. Premature ejaculation herbal treatment medication produced in Abia State, Nigeria, were analysed for its efficacy using Fluoxetine as a compared compound, a selective serotonin reuptake inhibitor in the treatment of PE. The herbal drugs were analysed using both classical and spectroscopic methods for the determination of its proximate content, phytochemical analysis, heavy metals concentrations and bioactive compounds. The interactions with the 5-HT2c serotonin receptors were investigated using in silico computational analysis, molecular docking, and pharmacokinetic properties of the selected compounds with ADMET screening. The availability of important phytochemicals such as alkaloids, terpenoids, flavonoids, tannins, and saponins was recorded, and the proximate content values were within the recommended ranges. Heavy metals such as Pb (46 mg/kg), Cd (22 mg/kg), Ni (35 mg/kg), and Mn (132 mg/kg) were found in excess of the recommended limits. Fifty-one compounds were discovered in the herbal drug samples, which were then screened for drug-ability using the Lipinski rule. In this study, six (6) compounds with the highest binding affinities among the compounds under investigation were reported. All six compounds were found to have binding affinity scores ranging from −7.5 kcal/mol to −10.5 kcal/mol. Their interactions in the active sites of the target receptors were with amino acids residues like ASP 134, VAL 135, SER 138, VAL 208, PHE 327, VAL 354, TRY 358, PHE 328, GLY 218, ASN 331, ALA 222, and LEU 350 sharing hydrophobic and electrostatic bonds. The study predicted the ADMET properties of the compounds under investigation and discovered that some of them had good pharmacokinetic properties and CYP2C19 enzyme inhibitory potential. This research suggests that these compounds could be active ingredients in herbal medications used to treat premature ejaculation. However, after using this medication, serum concentrations of patients can be measured to further assess its efficacy.
The advent of phyllobilins as bioactive phytochemicals – natural compounds derived from chlorophyll in medicinal plants and food with immunomodulatory activities
Authors: Vollmar Angelika M. , Moser Simone 
Published: February 2023

Abstract
The degradation of the green plant pigment chlorophyll has fascinated chemists and biologists alike over the last few decades. Bioactivities of the compounds formed in this biochemical degradation pathway, however, have only come to light recently. These natural compounds that are formed from chlorophyll during plant senescence are now called phyllobilins. In this review, we shortly discuss chlorophyll degradation and outline the so-far known bioactivities of selected phyllobilins (phylloleucobilin, dioxobilin-type phylloleucobilin, and phylloxanthobilin), and we also highlight the recently discovered immunomodulatory effects of a yellow phylloxanthobilin.
Beste Bedingungen für junge Ökonominnen und Ökonomen?
Authors: Bayer Christian , Englmaier Florian , Riphahn Regina T. , Schmidt-Dengler Philipp , Sondergeld Virginia , Sureth-Sloane Caren , v. Wangenheim Jonas , Weizsäcker Georg 
Published: February 2023

Zusammenfassung
Der Verein für Socialpolitik hat zur Bearbeitung seines Schwerpunktthemas „Nachwuchs“ für die Dauer der Kalenderjahre 2021–2022 eine Arbeitsgruppe eingerichtet – im Folgenden: AG Nachwuchs –, deren Aufgabe das Vorlegen eines umfassenden Berichts zur Situation der VWL-Promovierenden und -PostDocs im DACH-Raum ist. Gestützt auf Datenerhebungen und strukturierte Interviews formuliert die AG Nachwuchs in diesem Bericht zwei Empfehlungen, jeweils eine für den Doc- und den PostDoc-Bereich. Sie empfiehlt im PostDoc-Bereich, dass die Fakultäten bzw. verwandte VWL-Einrichtungen den Übergang zu Tenure-Track beschleunigen und ihn durch eine systematische Planung der Zahlenverhältnisse zwischen den Karrierestufen bei ihrem wissenschaftlichen Personal begleiten. Dadurch sollen bessere Karriereperspektiven erreicht werden. Sowohl die befragten Nachwuchskräfte als auch die befragten Professor:innen und Programmleitungen betonen die Thematik der Stellenperspektiven stark. Im Doc-Bereich dokumentieren die Erhebungsdaten eine überraschend geringe Zufriedenheit der VWL-Promovierenden mit der Betreuungssituation durch die Professorenschaft. Die AG Nachwuchs empfiehlt daher eine höhere Betreuungsdichte und eine stärkere Vernetzung von Promovierenden. Weitere Hilfestellungen für Promovierende können in Mehrfach- oder Teambetreuungen sowie in der Bereitstellung von Informationen über die Vielfalt möglicher Karrierewege bestehen.
The Association Between Physical Function and Hyperkyphosis in Older Females: A Systematic Review and Meta-analysis
Authors: Roghani Tayebeh , Allen Diane D. , Gladin Amy , Rahimi Alireza , Mehrabi Marziyeh , Rezaeian Zahra Sadat , Farajzadegan Ziba , Katzman Wendy B. 
Published: February 2023

Background and Purpose:
Thoracic hyperkyphosis may adversely influence physical function in older adults, but the literature is mixed and confounded by possible sex differences. This systematic review and meta-analysis aimed to examine the association between hyperkyphosis and physical function in older females.

Methods:
Scopus, ISI Web of Science, Cochrane Library, PubMed, CINAHL, and PEDro databases were searched through 2021 for studies that included measures of thoracic hyperkyphosis and physical function with extractable data for women older than 60 years. Studies were excluded if they were qualitative, case reports, case series, ecological studies, reviews, or were not published in English. The study quality and risk of bias were assessed using checklists from the National Heart, Lung, and Blood Institute. Data were synthesized using Cohen’s d effect size and 95% confidence interval (CI), and random-effects models were used for the meta-analyses.

Results and Discussion:
Three cohort and 22 cross-sectional studies of fair to good quality met the inclusion criteria. Eight studies reporting single-group data showed a moderate association between greater kyphosis angles and lower physical function (d = −0.57; 95% CI −0.73, −0.40). Fourteen studies reporting 2-group data showed a large negative effect on physical function for groups with greater kyphosis angles (d = −1.16; 95% CI −1.53, −0.78). Three studies that reported multivariate data also tended to show negative associations between physical function and hyperkyphosis. Limitations include a relative lack of causal evidence; confirming causation requires additional longitudinal studies. Studies have assessed various physical function categories, including strength, gait, and balance. Future studies could determine the categories of function most affected so that preventive interventions could target hyperkyphosis appropriately.

Conclusions:
Hyperkyphosis was associated with lower physical function in older women. Three cohort studies suggest that greater kyphosis angles may predict greater loss of physical function over time. These results imply that therapies that help to minimize hyperkyphosis may help preserve function in older women.
Screening for Osteoporosis Risk Among Community-Dwelling Older Adults: A Scoping Review
Authors: Wingood Mariana , Criss Michelle G. , Irwin Kent E. , Freshman Christina , Phillips Emma L. , Dhaliwal Puneet , Chui Kevin K. 
Published: February 2023

Background and Purpose:
Due to potential health-related consequences of osteoporosis (OP), health care providers who do not order imaging, such as physical therapists, should be aware of OP screening tools that identify individuals who need medical and rehabilitation care. However, current knowledge and guidance on screening tools is limited. Therefore, we explored OP screening tools that are appropriate and feasible for physical therapy practice, and evaluated tools' effectiveness by examining their clinimetric properties.

Methods:
A systematic search of the following databases was performed: PubMed, PEDro, PsycINFO, CINAHL, and Web of Science. Articles were included if the study population was 50 years and older, had a diagnosis of OP, if the screening tool was within the scope of physical therapy practice, and was compared to either a known diagnosis of OP or bone densitometry scan results. Included articles underwent multiple reviews for inclusion and exclusion, with each review round having a different randomly selected pair of reviewers. Data were extracted from included articles for participant demographics, outcome measures, cut-off values, and clinimetric properties. Results were categorized with positive and negative likelihood ratios (+LR/−LR) based on the magnitude of change in the probability of having or not having OP.

Results:
+LRs ranged from 0.15 to 20.21, with the Fracture Risk Assessment Tool (FRAX) and Study of Osteoporotic Fractures (SOF) having a large shift in posttest probability. −LRs ranged from 0.03 to 1.00, with the FRAX, Male Osteoporosis Risk Estimation Scores, Osteoporosis Self-Assessment Tool (OST), and Simple Calculated Osteoporosis Risk Estimation having a large shift in posttest probability.

Conclusion:
Tools with moderate-large shift for both +LR and −LR recommended for use are: (1) OST; (2) FRAX; and (3) SOF. The variability in cut-off scores and clinimetric properties based on gender, age, and race/ethnicities made it impossible to provide one specific recommendation for an OP screening tool. Future research should focus on OP risk prediction among males and racial and ethnic groups.
Numerical Simulation of Fatigue Behavior of Four Ti2AlNb Alloy Structural Parts
Authors: Zhu Zhenyu , Hao Wenfeng , Wu Weiguo 
Published: February 2023

AbstractIn aerospace engineering, many titanium alloy structures are subjected to fatigue loads and thus fail. Based on the Seeger fatigue life theory and the improved Lemaitre damage evolution theory, the fatigue behavior of four Ti2AlNb alloys is investigated. First, finite element models of four structural parts are established by ABAQUS software. Meanwhile, the fatigue life of four Ti2AlNb alloys is predicted by referring to the damage model parameters determined by previous work. Under the same initial conditions, the average errors of the predicted fatigue lives of the four structural parts are 20.1, 19.8, 20.9, and 19.5 %, respectively. The effects of load amplitude, temperature, and structural characteristics on the fatigue properties of Ti2AlNb alloy structural parts are studied. The stability of the two fatigue life simulation methods is analyzed. By comparing fatigue data of Ti2AlNb structural parts from various literature, the rationality of the simulated data is confirmed. Finally, the application of the Ti2AlNb structural fatigue database to machine learning is illustrated. These results provide a numerical simulation method for evaluating the fatigue life of various Ti2AlNb alloy aviation structural parts.
Effectiveness of Oral Fluid in Pathogenic Surveillance of Acute Respiratory Infection
Authors: Qi Huang , Jingyi Sun , Mei Dong , Jinxiang Wang , Yanfei Huang , Xiali Yu , Jianping Dong , Fangyao Liu , Lin Zou , Hui Xie , Fang Huang 
Published: February 2023

Objective:
Oral fluid (OF) is a new safe, non-invasive, convenient, and efficient biological sample that can be used for virus nucleic acid and antibody detection. Because few studies have performed surveillance of multiple respiratory pathogens, this study sought to explore the application value of OF in this field.

Methods:
OF and throat swabs were collected from December 2020 to December 2021 in patients with acute respiratory tract infections in Beijing. Multiplex real-time PCR was performed, and the detection performance of two samples was compared.

Results:
A total of 769 OF and throat swab samples were collected. The detection rates of respiratory pathogens in throat swabs and OF were 29.26% (225/769) and 20.81% (160/769), respectively. The sensitivity and specificity of the OF assay, compared with the throat swab assay, were 71.11% (160/225) and 100% (544/544), respectively. The two assays had excellent agreement (kappa = 0.78). The detection consistency varied among pathogens. For OF samples, the most common pathogen was the influenza B virus, and the highest detection rate was in the ≤5-year-old group. The highest positivity rate was observed in December 2021.

Conclusion:
OF samples have excellent potential for the epidemiological surveillance of respiratory pathogens, and may have application prospects in preventing and controlling infectious diseases.
DIELECTRIC METHOD FOR MEASURING THE CONTENT OF UNFROZEN WATER IN MINERAL SOIL
Authors: КАРАВАЙСКИЙ А.Ю. , ЛУКИН Ю.И. , ПОГОРЕЛЬЦЕВ Е.И. 
Published: February 2023

Путем совместных измерений содержания незамерзшей воды в мерзлой естественной минеральной почве диэлектрическим, калориметрическим и контактным методами подтверждена возможность практического применения диэлектрического метода для измерения содержания незамерзшей воды. Количество незамерзшей воды в калориметрическом и контактном методах оценивалось путем измерения влажности образцов за счет содержания незамерзшей воды, в диэлектрическом методе - путем измерения максимального содержания связанной воды. Определено, что значения влажности за счет содержания незамерзшей воды, измеренные с помощью калориметрического метода для образцов одного типа почвы с разной первоначальной влажностью, различаются в пределах 17 %. Значения влажности за счет содержания незамерзшей воды, найденные контактным методом, и значения содержания связанной воды в мерзлой почве, найденные диэлектрическим методом, лежат в диапазоне значений, измеренных с помощью калориметрического метода. Значения содержания связанной воды, найденные диэлектрическим методом, и значения влажности за счет содержания незамерзшей воды, полученные контактным методом, различаются не более чем на 17 %.
The possibility of using the dielectric method to determine the unfrozen water content in the frozen natural mineral soil was proved by establishing the relationship between the contents of soil water forms measured by the dielectric, calorimetric, and contact methods. The unfrozen water content in the sample was measured by the calorimetric and contact methods. In the dielectric method, it was estimated by measuring the maximum content of bound water. The unfrozen water content measured by the calorimetric method in the soil samples with different initial water contents varied within 17 %. The unfrozen water content measured by the contact method and the bound water content determined by the dielectric method were within the ranges of values determined by the calorimetric method. The values of the bound water content obtained by the dielectric method and the unfrozen water content obtained by the contact method differed by no more than 17 %.
DYNAMICS OF LAKES OF THE BOLSHOY AZAU GLACIER ON ELBRUS
Authors: АДЖИЕВ А.Х. , БЕККИЕВ М.Ю. , ДОКУКИН М.Д. , КАЛОВ Р.Х. , САВЕРНЮК Е.А. , ШАГИН С.И. 
Published: February 2023

В связи с высокими темпами деградации ледника Большой Азау на Эльбрусе возникла необходимость оценки развития озер на территории, освободившейся ото льда, и на самом леднике. С этой целью проведен анализ разновременной аэрокосмической информации за период 1957-2021 гг., материалов аэровизуальных обследований, сведений из интернет-источников, сообщений и фотографий туристов. Установлено существование в разное время 15 озер площадью 0.14-20.25 тыс. м2 на леднике Большой Азау и прилегающей территории. Выявлено длительное существование озера на контакте с ледником на перевале Эхо Войны с площадью до 4.5 тыс. м2 в период с 1971 по 2009 г. Максимальная площадь (20.25 тыс. м2) была определена по космоснимку 25.06.2009 г. у озера, расположенного на участке мертвых льдов срединных морен между левым и правым основными потоками льда ледника Большой Азау. В мульдах на поверхности ледника в разное время существовало три озера с максимальной площадью 7.86 тыс. м2. Озера на леднике Большой Азау появляются в основном в период таяния снежного покрова, когда в мульдах на участке оттока воды сохраняются в виде плотин массы метелевого снега. Исчезновение озер происходит в результате таяния снежных плотин, а также по подледным и подземным каналам стока.
High rates of degradation of the Bolshoy Azau Glacier on Elbrus make it necessary to assess the development of lakes on the ice-free land and on the glacier itself. For this purpose, aerospace data for the period of 1957-2021, as well as information from visual observations, Internet sources, and tourist photographs were analyzed. The existence of 15 lakes with an area of 0.14-20.25 thousand m2 on the Bolshoy Azau Glacier and the adjacent territory was recorded at various times. The long-term existence of the lake in contact with the glacier on the Echo of the War mountain passage covering with an area of up to 4.5 thousand m2 was revealed for the period of 1971-2009. The maximum area (20.25 thousand m2) was detected on a satellite image from June 25, 2009 for a lake on the dead ice part of the median moraine between left and right ice streams of the Bolshoy Azau Glacier. In the hollows on the glacier surface, up to three lakes with a maximum total area of 7.86 thousand m2 were observed in different times. Lakes on the Bolshoy Azau Glacier appeared mainly during the snow cover melting, while masses of drifted snow served as dams in the drainage area of hollows. These lakes disappeared after melting of drifted snow dams and/or in the course of drainage through subglacial and underground runoff channels.
Ila dan Zhihar Perspektif Tafsir Ayat Gender
Authors: Novitasari Yeni , Yunianti Revanda , Jannah Sabilla Wirdatul 
Published: February 2023

Abstract: Ila and Zhihar are one of the reasons for the breakup of marriages during the ignorance. Ila is the husband's oath not to have sex with his wife anymore. At the same time, Zhihar is the husband's words which equate his wife's back with his mother's. In the past, husbands were arbitrary towards their wives—Ila during the jahiliyyah period of more than two years. So the wife is hanged not given certainty in a long time. Likewise with Zhihar during the ignorance. Husbands arbitrarily send their wives away and make it a marriage break. After going down verses 226- 227 QS. Al-Baqarah about ila, then the husband who makes ila his wife is given a challenging period of 4 months. If he wants to return, then pay expiation. And in Surah Al-Mujadalah verses 1-4 about zhihar, the law of zhihar is a grave sin that is not punished by divorce and those who wants to return must pay expiation. From As-babun Nuzul then, Islam has raised the degree of women. Ila and zhihar are closely related to gender inequality or bias. Husband as a man has a superpower in controlling women, namely his wife. From this, M. Quraish Shihab explains in his gender equality verses that men and women have the same position, to help each other help and love each other. Even if there is a verse regarding the husband's position as the leader, then that too must not injure the rights of the wife.
Keywords : Ila, zhihar, gender, Quraish Shihab

Abstrak : Ila dan zhihar adalah salah satu jenis sebab putusnya perkawinan pada masa jahiliyah. Ila merupakan sumpah suami untuk tidak menggauli istrinya lagi. Sedangkan zhihar adalah pekataan suami yang menyamakan punggung istri sama dengan punggung ibunya. Dahulu para suami semena-mena terhadap istri. Ila pada masa jahiliyah lebih dari 2 tahun. Sehingga istri digantung tidak diberi kepastian dalam waktu yang lumayan lama. Begitu juga dengan Zhihar pada masa jahiliyah. Para suami seenaknya menzhihar istrinya, dan menjadikan hal itu sebagai putus perkawinan. Setelah turun ayat 226-227 QS. Al-Baqarah tentang ila, maka suami yang mengila istrinya diberikan waktu tangguh 4 bulan. Jika ia ingin kembali maka membayar kafarat. Dan Dalam surat Al-Mujadalah ayat 1-4 tentang zhihar, bahwa hukum zhihar adalah dosa besar, tidak dihukumi talak dan yang ingin kembali harus membayar kafarat. Dari Asbabun Nuzul tersebut maka, Islam telah mengangkat derajat perempuan. Ila dan zhihar erat sekali hubungannya dengan ketimpangan atau bias gender. Suami sebagai seorang laki-laki memiliki superpower dalam mengendalikan perempuan yaitu istrinya. Dari hal tersebut, M. Quraish Shihab menerangkan dalam ayat-ayat kesetaraan gendernya bahwa laki-laki dan perempuan memiliki kedudukan yang sama, untuk saling tolong menolong dan saling mengasihi. Kalaupun terdapat ayat yang tentang kedudukan suami sebagai pemimpinnya, maka itupun tak boleh mencederai hak-hak istri.
Kata Kunci : Ila, zhihar, gender, Quraish Shihab
Implementasi Produk Tabungan Berjangka dengan Akad Mudharabah di BMT Sidogiri Waru Sidoarjo
Authors: Indriani Iin , Qotimah Inggita Khusnul , Mustofa Imron 
Published: February 2023

Abstract: This study aims to determine how the implementation of term savings uses Mudharabah in KSPS BMT UGT Sidogiri Waru. This research employed a qualitative method that using an empirical juridical approach. The data collection technique in this research uses primary and secondary data sources that acquired from observation and interview with respondents to get valid data and library research. The study results show that the implementation of term savings in KSPS BMT UGT Sidogiri Waru by the principles of sharia. The performance of mudharabah musytarakah between the member and institution has been According to the rules and Fatwa MUI. But the profit sharing between BMT Sidogiri Waru and the central of BMT Sidogiri turned out to be different. The percentage of profit sharing within one month for term savings in BMT Sidogiri Waru is the same as the profit sharing of the sharia general savings 30%: 70%, meanwhile the percentage of profit sharing of term savings at the same period from the center is 50%: 50%.
Keywords: Implementation, Term Savings, Mudharabah, BMT Sidogiri.
Abstrak: Penelitian ini bertujuan untuk mengetahui bagaimana implementasi produk tabungan berjangka yang menggunakan akad Mudharabah di KSPS BMT UGT Sidogiri Cabang pembantu Waru Sidoarjo. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan yuridis empiris. Teknik pengumpulan data dalam penelitian ini menggunakan sumber data primer dan sekunder yang diperoleh melalui observasi dan wawancara dengan responden untuk mendapatkan data yang valid serta kajian pustaka dan literatur. Hasil dari penelitian ini menunjukkan bahwa implementasi tabungan berjangka di KSPS BMT UGT Sidogiri Capem Waru sudah sesuai dengan prinsip syariah. Penerapan akad mudharabah musytarakah dalam tabungan berjangka dan pembagian nisbah bagi hasil antara anggota dan lembaga juga telah sesuai dengan ketentuan dalam Fatwa MUI. Namun pembagian nisbah bagi hasil antara BMT Sidogiri Capem Waru dengan BMT Sidogiri pusat ternyata berbeda. Persentase nisbah bagi hasil pada jangka waktu 1 bulan untuk tabungan berjangka di BMT Sidogiri Waru ini sama dengan penetapan nisbah tabungan umum syariah yaitu 30% : 70%, sedangkan persentase nisbah bagi hasil dengan jangka waktu 1 bulan untuk tabungan berjangka dari pusat menetapkan 50% : 50%.
Kata kunci: Implementasi, Tabungan Berjangka, Mudharabah, BMT Sidogiri.