bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bimbingan Teknis Pembuatan Kontrol Lampu Berbasis Internet of Things (IoT) di SMKS Satria Kendari
Authors: Faslih Arman , Jaya St Nawal , Soeparyanto Try Sugiyarto , Ikhsan Ainussalbi Al , Nangi Jumadil , Aminur Aminur , Akbar Andi Mulk Rahim , Herdianto Herdianto , Fadli Muh. Miftahul , Sawal Muh. Jun 
Published: December 2022

Internet of Things atau disingkat IoT menjadi perkembangan teknologi yang dapat dilihat keberadaanya saat ini, keberadaanya semakin terasa seiring bermunculannya ide tepat guna yang mulai mencakup beberapa sisi dari kehidupan manusia. Menjadikan penggunaan Internet semakin meluas dan berkembang merupakan tujuan dari konsep IoT. Smartphone adalah teknologi perangkat keras yang penggunaanya telah mendominasi dunia, Pemanfaatan smartphone dibidang IoT sebagai sistem kendali, dapat dipadukan dengan penggunaan mikrokontroler yang telah diisi program terlebih dahulu telah mempermudah kegiatan sehari – hari. Salah satu kendala masyarakat terutama masyarakat yang memiliki pekerjaan kantoran terkadang lupa untuk menyalakan atau memadamkan lampu pada saat keluar untuk bekerja. Maupun, ketika pulang kerja biasanya lupa untuk memadamkan lampu kantor, hal seperti ini tentunya berdampak pada keamanan rumah atau kantor, serta menurunya ketahanan dan keawetan lampu dikarenakan menyala terus – menerus, disamping itu tentunya dapat menambah biaya penggunaan listrik,. Oleh karena itu berdasarkan permasalahan ini, kelompok Kuliah Kerja Nyata (KKN) Tematik Jurusan Teknik Elektro Universitas Halu Oleo membuat “Perancangan Prototype Kontrol Lampu Berbasis IoT”. Dengan harapan Produk ini dapat menyelesaikan permasalahn tersebut melihat dari kemudahan dalam penggunaan dan pengendaliannya. Pengabdian ini dilakukan bersama siswa – siswi SMK SATRIA sebagai mitra kegiatan, yang bertempat dikelurahan Lahundape Kecamatan Kendari Barat, dengan harapan mitra kegiatan mampu memahami dan membuat bahkan mengembangkan ide.
Sinomenine regulates immune cell subsets: Potential neuro-immune intervene for precise treatment of chronic pain
Authors: Lai Wei-Dong , Wang Song , You Wen-Ting , Chen Si-Jia , Wen Jun-Jun , Yuan Cun-Rui , Zheng Meng-Jia , Jin Yan , Yu Jie , Wen Cheng-Ping 
Published: December 2022

Chronic pain is a disease of long-lasting pain with unpleasant feelings mediated by central and (or) peripheral sensitization, its duration usually lasts more than 3 months or longer than the expected recovery time. The patients with chronic pain are manifested with enhanced sensitivity to noxious and non-noxious stimuli. Due to an incomplete understanding of the mechanisms, patients are commonly insensitive to the treatment of first line analgesic medicine in clinic. Thus, the exploration of non-opioid-dependent analgesia are needed. Recent studies have shown that “sinomenine,” the main active ingredient in the natural plant “sinomenium acutum (Thunb.) Rehd. Et Wils,” has a powerful inhibitory effect on chronic pain, but its underlying mechanism still needs to be further elucidated. A growing number of studies have shown that various immune cells such as T cells, B cells, macrophages, astrocytes and microglia, accompanied with the relative inflammatory factors and neuropeptides, are involved in the pathogenesis of chronic pain. Notably, the interaction of the immune system and sensory neurons is essential for the development of central and (or) peripheral sensitization, as well as the progression and maintenance of chronic pain. Based on the effects of sinomenine on immune cells and their subsets, this review mainly focused on describing the potential analgesic effects of sinomenine, with rationality of regulating the neuroimmune interaction.
Physician antibiotic hydration preferences for biologic antibacterial envelopes during cardiac implantable device procedures
Authors: Deering Thomas F. , Catanzaro John N. , Woodard David A. 
Published: December 2022

BackgroundCardiac implantable electronic device (CIED) infection is a potentially serious complication of CIED procedures. Infection risk mitigation includes using guideline-recommended pre-operative intravenous antibacterial prophylaxis (IV ABX). The use of antibiotic-eluting CIED envelopes has also been shown to reduce infection risk. The relationship between and potential benefits associated with guideline-recommended IV ABX in combination with antibacterial envelopes have not been characterized.MethodsBiologic envelopes made from non-crosslinked extracellular matrix (ECM) were implanted into 1,102 patients receiving CIEDs. The implanting physician decided patient selection for using a biologic envelope and envelope hydration solution. Observational data was analyzed on IV ABX utilization rates, antibacterial envelope usage, and infection outcomes.ResultsOverall compliance with IV ABX was 96.6%, and most patients received a biologic envelope hydrated in antibiotics (77.1%). After a mean follow-up of 223 days, infection rates were higher for sites using IV ABX &lt;80% of the time vs. sites using ≥80% (5.6% vs. 0.8%, p = 0.008). Physicians demonstrated preference for hydration solutions containing gentamicin in higher-risk patients, which was found by multivariate analysis to be associated with a threefold reduction in infection risk (OR 3.0, 95% CI, 1.0–10.0).ConclusionThese findings suggest that use of antibiotics, particularly gentamicin, in biologic envelope hydration solution may reduce infection risk, and use of antibacterial envelopes without adjunct IV ABX may not be sufficient to reduce CIED infections.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT02530970].
54 years of microboring community history explored by machine learning in a massive coral from Mayotte (Indian Ocean)
Authors: Alaguarda D. , Brajard J. , Coulibaly G. , Canesi M. , Douville E. , Le Cornec F. , Lelabousse C. , Tribollet A. 
Published: December 2022

Coral reefs are increasingly in jeopardy due to global changes affecting both reef accretion and bioerosion processes. Bioerosion processes dynamics in dead reef carbonates under various environmental conditions are relatively well understood but only over a short-term limiting projections of coral reef evolution by 2100. It is thus essential to monitor and understand bioerosion processes over the long term. Here we studied the assemblage of traces of microborers in a coral core of a massive Diploastrea sp. from Mayotte, allowing us to explore the variability of its specific composition, distribution, and abundance between 1964 and 2018. Observations of microborer traces were realized under a scanning electron microscope (SEM). The area of coral skeleton sections colonized by microborers (a proxy of their abundance) was estimated based on an innovative machine learning approach. This new method with 93% accuracy allowed analyzing rapidly more than a thousand SEM images. Our results showed an important shift in the trace assemblage composition that occurred in 1985, and a loss of 90% of microborer traces over the last five decades. Our data also showed a strong positive correlation between microborer trace abundance and the coral bulk density, this latter being particularly affected by the interannual variation of temperature and cumulative insolation. Although various combined environmental factors certainly had direct and/or indirect effects on microboring species before and after the breakpoint in 1985, we suggest that rising sea surface temperature, rainfall, and the loss of light over time were the main factors driving the observed trace assemblage change and decline in microborer abundance. In addition, the interannual variability of sea surface temperature and instantaneous maximum wind speed appeared to influence greatly the occurrence of green bands. We thus stress the importance to study more coral cores to confirm the decadal trends observed in the Diploastrea sp. from Mayotte and to better identify the main factors influencing microboring communities, as the decrease of their abundance in living massive stress tolerant corals may have important consequences on their resilience.
Evaluating performance of the 2019 EULAR/ACR, 2012 SLICC, and 1997 ACR criteria for classifying adult-onset and childhood-onset systemic lupus erythematosus: A systematic review and meta-analysis
Authors: Lerkvaleekul Butsabong , Chobchai Pantira , Rattanasiri Sasivimol , Vilaiyuk Soamarat 
Published: December 2022

IntroductionThe American College of Rheumatology (ACR) 1997, Systemic Lupus International Collaborating Clinics (SLICC) 2012, and European League Against Rheumatism (EULAR)/ACR 2019 SLE criteria are often used to classify patients with adult-onset and childhood-onset systemic lupus erythematosus (SLE) in clinical practice because there are currently no diagnostic criteria for SLE. However, there is scarce evidence regarding which criteria are best for diagnosing patients with adult-onset and childhood-onset SLE.MethodsWe searched Medline and Scopus databases for English-language articles from inception through October 2021. Data were extracted from the included publications by two independent reviewers. We performed bivariate meta-analysis with a random-effects model to pool diagnostic parameters. Meta-regression and subgroup analyses were performed to explore heterogeneity sources. We used network meta-analysis to compare diagnosis performance among the three criteria and ranked them in descending order. Publication bias was assessed using Deeks’ funnel plot.ResultsWe included 29 studies for systematic review and meta-analysis. Of these, 18 studies involved adult-onset SLE and 11 studies involved childhood-onset SLE. The pooled sensitivities of the three criteria for diagnosis of adult-onset SLE were comparable between SLICC 2012 and EULAR/ACR 2019 [95.86, 95% confidence interval (CI) 92.28–97.81 vs. 94.79, 95% CI 92.03–96.63]; pooled specificity was highest in ACR 1997 (92.24, 95% CI 87.06–95.46). In childhood-onset SLE, pooled sensitivity was highest in SLICC 2012 (93.76, 95% CI 89.45–96.39), and pooled specificity was highest in ACR 1997 (95.89, 95% CI 91.73–98.00). In network meta-analysis, the pooled diagnostic odds ratio ranked highest for EULAR/ACR 2019 (131.570, 95% CI 61.50–281.47) in adult-onset SLE and ranked highest for SLICC 2012 (191.07, 95% CI 76.06–480.01) in childhood-onset SLE. Deeks’ funnel plot showed no publication bias.ConclusionWe found that the diagnostic performance of the ACR 1997, SLICC 2012, and EULAR/ACR 2019 criteria differed between adult-onset and childhood-onset SLE. EULAR/ACR 2019 performed best for adult-onset SLE and SLICC 2012 was best for childhood-onset SLE in classifying patients with SLE.Systematic review registration[www.ClinicalTrials.gov], identifier [CRD420 21281586].
The application of targeted nanopore sequencing for the identification of pathogens and resistance genes in lower respiratory tract infections
Authors: Zhang Hongying , Wang Meng , Han Ximei , Wang Ting , Lei Yanjuan , Rao Yu , Xu Peisong , Wang Yunfei , Gu Hongcang 
Published: December 2022

ObjectivesLower respiratory tract infections (LRTIs) are one of the causes of mortality among infectious diseases. Microbial cultures commonly used in clinical practice are time-consuming, have poor sensitivity to unculturable and polymicrobial patterns, and are inadequate to guide timely and accurate antibiotic therapy. We investigated the feasibility of targeted nanopore sequencing (TNPseq) for the identification of pathogen and antimicrobial resistance (AMR) genes across suspected patients with LRTIs. TNPseq is a novel approach, which was improved based on nanopore sequencing for the identification of bacterial and fungal infections of clinical relevance.MethodsThis prospective study recruited 146 patients suspected of having LRTIs and with a median age of 61 years. The potential pathogens in these patients were detected by both TNPseq and the traditional culture workups. We compared the performance between the two methods among 146 LRTIs-related specimens. AMR genes were also detected by TNPseq to prompt the proper utilization of antibiotics.ResultsAt least one pathogen was detected in 133 (91.1%) samples by TNPseq, but only 37 (25.3%) samples contained positive isolates among 146 cultured specimens. TNPseq possessed higher sensitivity than the conventional culture method (91.1 vs. 25.3%, P &lt; 0.001) in identifying pathogens. It detected more samples with bacterial infections (P &lt; 0.001) and mixed infections (P &lt; 0.001) compared with the clinical culture tests. The most frequent AMR gene identified by TNPseq was blaTEM (n = 29), followed by blaSHV (n = 4), blaKPC (n = 2), blaCTX−M (n = 2), and mecA (n = 2). Furthermore, TNPseq discovered five possible multi-drug resistance specimens.ConclusionTNPseq is efficient to identify pathogens early, thus assisting physicians to conduct timely and precise treatment for patients with suspected LRTIs.
Transient receptor potential vanilloid type 4 (TRPV4) promotes tumorigenesis via NFAT4 activation in nasopharyngeal carcinoma
Authors: Zhang Peng , Li Ke , Wang Zhen , Wu Yongjin , Zhang Hua , Ma Fang , Liu Xiao-Yu , Tong Michael C.F. , Ru Xiaochen , Zhang Xiangmin , Zeng Xianhai 
Published: December 2022

Transient receptor potential vanilloid type 4 (TRPV4) can function as an oncogene or tumor suppressor depending on the tumor types. However, little is known regarding the effect of TRPV4 in nasopharyngeal carcinoma (NPC), a highly prevalent malignancy in Southern China and Southeast Asia. We found that TRPV4 mRNA and protein levels were significantly upregulated in NPC tissues. In addition, activation of TRPV4 in NPC cell lines using GSK1016790A (100 nM) induced a Ca2+ influx, whereas pharmacological inhibition or gene knockdown of TRPV4 reduced the proliferation rates of NPC cells. TRPV4 knockdown also decreased the growth of tumor xenografts in vivo. Mechanistically, TRPV4-mediated tumorigenesis is dependent on the activation of Ca2+/calcineurin/calcineurin-nuclear factor of activated T cell 4 (NFAT4) signaling. Furthermore, NFAT4 protein level was overexpressed in NPC tissues and correlated positively with TRPV4. Taken together, TRPV4 promotes the malignant potential of NPC cells by activating NFAT4 signaling. Our findings highlight TRPV4-NFAT4 axis as a potential therapeutic target in NPC.
Perioperative sleep deprivation activates the paraventricular thalamic nucleus resulting in persistent postoperative incisional pain in mice
Authors: Li Lei , Zhang Huijie , Zheng Zhenli , Ma Nan , Zhang Yidan , Liu Yaping , Zhang Jingjing , Su Songxue , Zang Weidong , Shao Jinping , Cao Jing 
Published: December 2022

BackgroundThe duration of postsurgical pain is closely correlated with perioperative stress. Most patients suffer short-term sleep disorder/deprivation before and/or after surgery, which leads to extended postsurgical pain by an undetermined mechanism. The paraventricular thalamus (PVT) is a critical area that contributes to the regulation of feeding, awakening, and emotional states. However, whether the middle PVT is involved in postoperative pain or the extension of postoperative pain caused by perioperative sleep deprivation has not yet been investigated.MethodsWe established a model of postoperative pain by plantar incision with perioperative rapid eye movement sleep deprivation (REMSD) 6 h/day for 3 consecutive days in mice. The excitability of the CaMKIIα+ neurons in the middle PVT (mPVTCaMKIIα) was detected by immunofluorescence and fiber photometry. The activation/inhibition of mPVTCaMKIIα neurons was conducted by chemogenetics.ResultsREMSD prolonged the duration of postsurgical pain and increased the excitability of mPVTCaMKIIα neurons. In addition, mPVTCaMKIIα neurons showed increased excitability in response to nociceptive stimuli or painful conditions. However, REMSD did not delay postsurgical pain recovery following the ablation of CaMKIIα neurons in the mPVT. The activation of mPVTCaMKIIα neurons prolonged the duration of postsurgical pain and elicited anxiety-like behaviors. In contrast, inhibition of mPVTCaMKIIα neurons reduced the postsurgical pain after REMSD.ConclusionOur data revealed that the CaMKIIα neurons in the mPVT are involved in the extension of the postsurgical pain duration induced by REMSD, and represented a novel potential target to treat postoperative pain induced by REMSD.
Early transient dysautonomia predicts the risk of infantile epileptic spasm syndrome onset: A prospective cohort study
Authors: Goswami Ipsita , Maguire Bryan , Chau Vann , Tam Emily W. , Pinchefsky Elana , Whitney Robyn , Wilson Diane , Miller Steven P. , Cortez Miguel A. 
Published: December 2022

BackgroundInfantile epileptic spasm syndrome (IESS) is an age-dependent epileptic encephalopathy with a significant risk of developmental regression. This study investigates the association between heart rate variability (HRV) in infants at risk of IESS and the clinical onset of IESS.MethodsSixty neonates at risk of IESS were prospectively followed from birth to 12 months with simultaneous electroencephalogram (EEG) and electrocardiogram recordings for 60 min at every 2-month interval. HRV metrics were calculated from 5 min time-epoch during sleep including frequency domain measures, Poincare analysis including cardiac vagal index (CVI) and cardiac sympathetic index (CSI), and detrended fluctuation analysis (DFA α1, DFA α2). To assess the effect of each HRV metric at the 2-month baseline on the time until the first occurrence of either hypsarrhythmia on EEG and/or clinical spasm, univariate cox-proportional hazard models were fitted for each HRV metric.ResultsInfantile epileptic spasm syndrome was diagnosed in 20/60 (33%) of the cohort in a 12-month follow-up and 3 (5%) were lost to follow-up. The median age of developing hypsarrhythmia was 25 (7–53) weeks and clinical spasms at 24 (8–40) weeks. Three (5%) patients had clinical spasms without hypsarrhythmia, and 5 (8%) patients had hypsarrhythmia before clinical spasms at the initial presentation. The infants with high CSI (hazard ratio 2.5, 95% CI 1.2–5.2,P= 0.01) and high DFA α1 (hazard ratio 16, 95% CI 1.1–240,P= 0.04) at 2 months were more likely to develop hypsarrhythmia by the first year of age. There was a trend toward decreasing CSI and DFA α1 and increasing CVI in the first 8 months of age.ConclusionOur data suggest that relative sympathetic predominance at an early age of 2 months may be a potential predictor for developing IESS. Hence, early HRV patterns may provide valuable prognostic information in children at risk of IESS allowing early detection and optimization of cognitive outcomes. Whether early intervention to restore sympathovagal balanceper sewould provide clinical benefit must be addressed by future studies.
Activation likelihood estimation identifies brain regions activated during puncturing at Hegu in healthy volunteers: A meta-analysis
Authors: Gao Zhen , Cui Mengjie , Zhang Jing , Ji Laixi 
Published: December 2022

BackgroundHegu is the most commonly used acupoints for pain relief. Recently, several functional neuroimaging studies have been performed on acupuncture at Hegu in healthy volunteers, but these studies have yielded diverse findings. Therefore, there is an urgent need to understand the brain response characteristics of acupuncture at Hegu.MethodsNeuroimaging studies on acupuncture at Hegu published before October 2022 were collected from PubMed, Web of Science, Google Scholar, Embase, and CNKI (China National Knowledge Infrastructure) databases, and were screened by strict inclusion and exclusion criteria. The extraction of brain coordinates was performed by two independent researchers, and the results were analyzed using activation likelihood estimation (ALE) analysis based on quantitative coordinates.ResultsIn total, 338 studies were searched, of which 19 studies were included in the final analysis after a rigorous double-blind screening review. Activation likelihood estimation showed that postcentral gyrus in the left brain were activated, whereas the anterior cingulate in the left brain and superior temporal gyrus in the right brain were deactivated.ConclusionAcupuncture at Hegu in healthy volunteers did not reveal specific brain regions. This finding implies that organismal status of the study subjects may have an important impact on the effect of acupoints.Systematic review registration[https://www.crd.york.ac.uk], identifier [CRD42020197296].
Splenic arterial neurovascular bundle stimulation in esophagectomy: A feasibility and safety prospective cohort study
Authors: Brinkman David J. , Gupta Isha , Matteucci Paul B. , Ouchouche Sebastien , de Jonge Wouter J. , Coatney Robert W. , Salam Tariqus , Chew Daniel J. , Irwin Eric , Yazicioglu R. Firat , Nieuwenhuizen Grard A. P. , Vervoordeldonk Margriet J. , Luyer Misha D. P. 
Published: December 2022

IntroductionThe autonomic nervous system is a key regulator of inflammation. Electrical stimulation of the vagus nerve has been shown to have some preclinical efficacy. However, only a few clinical studies have been reported to treat inflammatory diseases. The present study evaluates, for the first time, neuromodulation of the splenic arterial neurovascular bundle (SpA NVB) in patients undergoing minimally invasive esophagectomy (MIE), in which the SpA NVB is exposed as part of the procedure.MethodsThis single-center, single-arm study enrolled 13 patients undergoing MIE. During the abdominal phase of the MIE, a novel cuff was placed around the SpA NVB, and stimulation was applied. The primary endpoint was the feasibility and safety of cuff application and removal. A secondary endpoint included the impact of stimulation on SpA blood flow changes during the stimulation, and an exploratory point was C-reactive protein (CRP) levels on postoperative day (POD) 2 and 3.ResultsAll patients successfully underwent placement, stimulation, and removal of the cuff on the SpA NVB with no adverse events related to the investigational procedure. Stimulation was associated with an overall reduction in splenic arterial blood flow but not with changes in blood pressure or heart rate. When compared to historic Propensity Score Matched (PSM) controls, CRP levels on POD2 (124 vs. 197 mg/ml, p = 0.032) and POD3 (151 vs. 221 mg/ml, p = 0.033) were lower in patients receiving stimulation.ConclusionThis first-in-human study demonstrated for the first time that applying a cuff around the SpA NVB and subsequent stimulation is safe, feasible, and may have an effect on the postoperative inflammatory response following MIE. These findings suggest that SpA NVB stimulation may offer a new method for immunomodulatory therapy in acute or chronic inflammatory conditions.