bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineered Neutrophil Nanovesicles for Inhibiting Corneal Neovascularization by Synergistic Anti‐Inflammatory, Anti‐VEGF, and Chemoexcited Photodynamic Therapy
Authors: Liu Xiaoxue , Bi Yingxuan , Wei Chaoqun , Zhang Ye , Liu Xiaoyu , Guo Xinghan , Zhao Longfei , Zhang Jingjing , Wang Changlong , Gao Hua 
Published: January 2025

AbstractCorneal neovascularization (CorNV) develops under various pathological conditions and is one of the main causes of blindness. Due to that CorNV progression involves multiple steps, anti‐vascular endothelial growth factor (VEGF) drugs alone could not sufficiently suppress this process, highlighting an urgent need for an efficient delivery system for the multi‐step management of CorNV. In this study, a neutrophil nanovesicle‐based eye drop (NCCR) is developed for CorNV therapy that simultaneously inhibits angiogenesis and inflammation, while eliminating pathological cells through chemoexcited photodynamic therapy (PDT). NCCR targets inflammatory lesions by leveraging the expression of chemokine receptors from the source cells. Then, NCCR exerts inhibitory effects on the sequential steps of neovascularization. First, it acts as a decoy and exerts an anti‐inflammatory effect by neutralizing cytokines via its receptors on the surface of nanovesicles. Second, thioketals bond‐linked ranibizumab is released in the high reactive oxygen species microenvironment of CorNV sites to bind VEGF, inhibiting vascular endothelial cell activation and proliferation. Finally, chemoexcited PDT eliminates preformed corneal blood vessels, disrupting tube formation and pericyte recruitment. The synergistic effects of NCCR on angiogenesis and inflammation, combined with the induction of apoptosis in neovessels via chemoexcited PDT, offer a novel and efficient strategy for CorNV treatment.
The First Molecular Ferroelectric Mott Insulator
Authors: Yao Jie , Sun Wencong , Guo Jianfeng , Feng Zi‐Jie , Pan Qiang , Peng Jin , Cheng Zhihai , Dong Shuai , Xiong Ren‐Gen , You Yu‐Meng 
Published: January 2025

AbstractWith the discovery of colossal magnetoresistance materials and high‐temperature superconductors, Mott insulators can potentially undergo a transition from insulating state to metallic state. Here, in molecular ferroelectrics system, a Mott insulator of (C7H14N)3V12O30 has been first synthesized, which is a 2D organic–inorganic ferroelectric with composition of layered vanadium oxide and quinuclidine ring. Interestingly, accompanied by the ferroelectric phase transition, (C7H14N)3V12O30 changes sharply in conductivity. The occurrence of a Mott transition has been proven by electric transport measurements and theoretical calculations. This research has significantly expanded the applicative horizons of ferroelectric materials, and offering an ideal platform for the investigation of strongly correlated electron systems.
Ultrafast Preparation of High‐Entropy NASICON Cathode Enables Stabilized Multielectron Redox and Wide‐Temperature (−50–60 °C) Workability in Sodium‐Ion Batteries
Authors: Du Miao , Li Kai , Yu Ning , Hao Ze‐Lin , Guo Jin‐Zhi , Liang Hao‐Jie , Gu Zhen‐Yi , Zhang Xiao‐Hua , Zhang Kai‐Yang , Liu Yan , Yang Jia‐Lin , Liu Yi‐Tong , Wu Xing‐Long 
Published: January 2025

AbstractAvoiding severe structural distortion, irreversible phase transition, and realizing the stabilized multielectron redox are vital for promoting the development of high‐performance NASICON‐type cathode materials for sodium‐ion batteries (SIBs). Herein, a high‐entropy Na3.45V0.4Fe0.4Ti0.4Mn0.45Cr0.35(PO4)3 (HE‐Na3.45TMP) cathode material is prepared by ultrafast high‐temperature shock, which inhibits the possibility of phase separation and achieves reversible and stable multielectron transfer of 2.4/2.8 e− at voltage range of 2.0–4.45/1.5–4.45 V versus Na+/Na (the capacity of 137.2/162.0 mAh g−1). The galvanostatic charge/discharge and in‐situ X‐ray diffraction tests indicate the sequential redox reactions and approximate solid solution phase transition behavior of HE‐Na3.45TMP. Density functional theory calculations analyze the migration pathways and energy barriers, further confirming the superior reaction kinetics of HE‐Na3.45TMP. Accordingly, the HE‐Na3.45TMP exhibits outstanding wide temperature applicability and can operate stably in the temperature range of −50–60 °C, accompanied by a capacity retention of 92.8% after 400 cycles at −40 °C and a capacity of 73.7 mAh g−1 even at −50 °C. The assembled hard carbon//HE‐Na3.45TMP full‐cell offers an energy density of ≈301 Wh kg−1 based on total cathode and anode active mass, verifying the application feasibility of HE‐Na3.45TMP. This work provides an innovative and ultrafast pathway to rationally fabricate high‐performance cathodes for SIBs.
Self‐Supported Super‐Hydrophilic Interconnected Nanospikes and Particles of MoS2‐Ni3S2/NF with Optimum d‐Band Center for Anion Exchange Membrane Water Electrolyzer
Authors: Kumar Yogesh , Barik Sidharth , Samudre Nikhil S. , Kharabe Geeta Pandurang , Chauhan Inderjeet , Manna Narugopal , Bhat Suresh , Kurungot Sreekumar 
Published: January 2025

AbstractThere is an imperative need for highly efficient electrocatalysts for cost‐effective hydrogen production. Herein, a self‐supported, hybrid composite as a bifunctional electrocatalyst is introduced. This is achieved by in situ growth of MoS2‐Ni3S2 on nickel foam (NF), designated as MoS2‐Ni3S2/NF, synthesized by a facile one‐step hydrothermal synthesis method. MoS2‐Ni3S2/NF exhibits low overpotentials of only 187 and 146 mV for OER and HER, respectively, to achieve a current density of 10 mA cm−2 in 1 M KOH. The practical application of the designed bifunctional electrocatalyst is verified by constructing the MoS2‐Ni3S2/NF || MoS2‐Ni3S2/NF symmetrical membrane electrode assembly (MEA) of 4 cm2 working area for the anion exchange membrane water electrolyzer. The system shows continuous electrolysis for the monitored 48 h duration. For OER, an optimum d‐band center of −1.66 eV for the heterostructure is calculated from the Density Functional Theory (DFT) studies. The factors like the unique structure of the electrocatalyst, enhanced hydrophilicity, improved electrochemically accessible number of sites (ECASs), and optimum d‐band center, are expected to be the primary contributors to the system's improved performance. Thus, the present finding unveils a straightforward synthesis approach for creating a stable electrocatalyst for advancing commercial water electrolysis in the realm of renewable electrochemical energy conversion.
Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing
Authors: Wang Jiahe , Fan Yi , Luo Guowen , Xiong Liang , Wang Lijie , Wu Zhuoxuan , Wang Jiayi , Peng Zhengying , Rosen Clifford J , Lu Kefeng , Jing Junjun , Yuan Quan , Zhang Zhenwei , Zhou Chenchen 
Published: January 2025

AbstractBiomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled‐coil (WAC) is localized to nuclear speckles via its WW domain and plays a pivotal role in regulating alternative splicing through the formation of biomolecular condensates via its C‐terminal coiled‐coil (CC) domain. WAC acts as a scaffold protein and facilitates the integration of RNA‐binding motif 12 (RBM12) into nuclear speckles, where RBM12 potentially interacts with the spliceosomal U5 small nuclear ribonucleoprotein (snRNP). Importantly, knockdown of RBM12, or deletion of the WAC CC domain led to altered splicing outcomes, resulting in an elevated level of BECN1‐S, the short splice variant of BECN1 that is shown to upregulate mitophagy. Thus, the findings reveal a previously unrecognized mechanism for the nuclear regulation of mitochondrial function through liquid–liquid phase separation (LLPS) and provide insights into the pathogenesis of WAC‐related disorders.
Improved Efficacy of Triple‐Negative Breast Cancer Immunotherapy via Hydrogel‐Based Co‐Delivery of CAR‐T Cells and Mitophagy Agonist
Authors: Li Guodong , Du Ruoxin , Wang Donghui , Zhang Xiangmei , Wang Lizhuo , Pu Shuangpeng , Li Xiaoju , Wang Shuning , Zhang Juliang , Liu Beichen , Gao Yuan , Zhao Huadong 
Published: January 2025

AbstractLeaky and structurally abnormal blood vessels and increased pressure in the tumor interstitium reduce the infiltration of CAR‐T cells in solid tumors, including triple‐negative breast cancer (TNBC). Furthermore, high burden of tumor cells may cause reduction of infiltrating CAR‐T cells and their functional exhaustion. In this study, various effector‐to‐target (E:T) ratio experiments are established to model the treatment using CAR‐T cells in leukemia (high E:T ratio) and solid tumor (low E:T ratio). It is found that the antitumor immune response is decreased in solid tumors with low E:T ratio. Furthermore, single cell sequencing is performed to investigate the functional exhaustion at a low ratio. It is revealed that the inhibition of mitophagy‐mediated mitochondrial dysfunction diminished the antitumor efficacy of CAR‐T‐cell therapy. The mitophagy agonist BC1618 is screened via AI‐deep learning and cytokine detection, in vivo and in vitro studies revealed that BC1618 significantly strengthened the antitumor response of CAR‐T cells via improving mitophagy. Here, injection hydrogels are engineered for the controlled co‐delivery of CAR‐T cells and BC1618 that improves the treatment of TNBC. Local delivery of hydrogels creates an inflammatory and mitophagy‐enhanced microenvironment at the tumor site, which stimulates the CAR‐T cells proliferation, provides antitumor ability persistently, and improves the effect of treatment.
Peptide‐Drug Conjugate for Therapeutic Reprogramming of Tumor‐Associated Macrophages in Breast Cancer
Authors: Lepland Anni , Peranzoni Elisa , Haljasorg Uku , Asciutto Eliana K. , Crespí‐Amer Maria , Modesti Lorenzo , Kilk Kalle , Lombardia Manuel , Acosta Gerardo , Royo Miriam , Peterson Pärt , Marigo Ilaria , Teesalu Tambet , Scodeller Pablo 
Published: January 2025

AbstractIn triple‐negative breast cancer (TNBC), pro‐tumoral macrophages promote metastasis and suppress the immune response. To target these cells, a previously identified CD206 (mannose receptor)‐binding peptide, mUNO was engineered to enhance its affinity and proteolytic stability. The new rationally designed peptide, MACTIDE, includes a trypsin inhibitor loop, from the Sunflower Trypsin Inhibitor‐I. Binding studies to recombinant CD206 revealed a 15‐fold lower KD for MACTIDE compared to parental mUNO. Mass spectrometry further demonstrated a 5‐fold increase in MACTIDE's half‐life in tumor lysates compared to mUNO. Homing studies in TNBC‐bearing mice shows that fluorescein (FAM)‐MACTIDE precisely targeted CD206+ tumor‐associated macrophages (TAM) upon intravenous, intraperitoneal, and even oral administration, with minimal liver accumulation. MACTIDE was conjugated to Verteporfin, an FDA‐approved photosensitizer and YAP/TAZ pathway inhibitor to create the conjugate MACTIDE‐V. In the orthotopic 4T1 TNBC mouse model, non‐irradiated MACTIDE‐V‐treated mice exhibited anti‐tumoral effects comparable to those treated with irradiated MACTIDE‐V, with fewer signs of toxicity, prompting further investigation into the laser‐independent activity of the conjugate. In vitro studies using bone marrow‐derived mouse macrophages showed that MACTIDE‐V excluded YAP from the nucleus, increased phagocytic activity, and upregulated several genes associated with cytotoxic anti‐tumoral macrophages. In mouse models of TNBC, MACTIDE‐V slowed primary tumor growth, suppressed lung metastases, and increased markers of phagocytosis and antigen presentation in TAM and monocytes, increasing the tumor infiltration of several lymphocyte subsets. MACTIDE‐V is proposed as a promising peptide‐drug conjugate for modulating macrophage function in breast cancer immunotherapy.
Single Cell‐Pair Proteomics for Decoding Immune‐Cancer Cell Interactions
Authors: Xu Qin‐Qin , Jiang Yi‐Rong , Chen Jian‐Bo , Wu Jie , Chen Yi‐Xue , Fan Qian‐Xi , Wang Hui‐Feng , Yang Yi , Pan Jian‐Zhang , Fang Qun 
Published: January 2025

AbstractThe efficacy of cancer immunotherapy is significantly influenced by the heterogeneity of individual tumors and immune responses. To investigate this phenomenon, a microfluidic platform is constructed for profiling immune‐cancer cell interactions at the single‐cell proteomics level for the first time. Based on the platform, a comprehensive workflow is proposed for achieving accurate single‐cell pairing of an immune cell and a cancer cell with low cell damage and high success rate up to 95%, cell pair co‐culture, and real‐time microscopic monitoring of the cell‐pair interactions, cell pair retrieval, mass spectrometry‐based proteomic analysis of singe cell pairs, and decoupling of the proteomic information for each cell within the cell pair with the stable‐isotope labeling method. With the workflow, the interactions of single natural killer (NK) cells and single K562 tumor cells are investigated based on real‐time images and single cell‐pair proteomics. Notably, an identification depth of over 1000 protein groups in a single cell‐pair is achieved, leading to the discovery of sub‐clusters of NK cells with different functions and the identification of important biomarkers for cancer treatments. This demonstrates the unique capability of the present platform in providing substantial and comprehensive datasets for profiling immune‐cancer cell interactions, discovering heterogeneous immune responses, and predicting biomarkers in the study of cancer immunotherapy.
Strong Polar Optical Phonon Screening and Softening Enhance the Thermoelectric Performance of Zintl Compounds
Authors: Guo Muchun , Liu Ming , Yuan Donglin , Chen Hong , Sun Chenyue , Zhang Qinyong , Zhu Yuke , Guo Fengkai , Yu Yuan , Sui Jiehe 
Published: January 2025

AbstractTernary CaAl2Si2‐structure‐type Zintl compounds are promising p‐type counterparts to n‐type Mg3(Sb, Bi)2 for thermoelectric energy conversion. However, many of these p‐type Zintl compounds suffer from low carrier concentration and mobility, resulting in poor thermoelectric performance. Here, it is revealed that their ultralow mobility stems from strong polar optical phonon scattering, and demonstrate that their electrical transport properties can be dramatically boosted by employing a screening effect. By employing isovalent alloying with Cd and Yb, along with Li aliovalent acceptor doping in CaMg2Sb2 to increase carrier concentration and induce a strong screening effect, a significant improvement in carrier mobility and, consequently, the power factor is achieved. Moreover, isovalent alloying weakens chemical bonding, causing the softening and deceleration of both acoustic and optical phonons and, thus, a reduction in lattice thermal conductivity. As a result, a ZT of 1.1 is achieved in the Ca0.69Yb0.3Li0.01Mg1.5Cd0.5Sb2 sample at 773 K, representing a 30‐fold increase compared to the pristine CaMg2Sb2. It is also proposed that the polar coupling constant can serve as a criterion for identifying materials with low intrinsic carrier concentration and mobility but with potential for thermoelectric applications facilitating the development of other thermoelectric materials beyond CaAl2Si2‐structure‐type Zintl compounds.
Diverse Clinical Presentation of RAC1‐Related Intellectual Developmental Disorder
Authors: Upadia Jariya , Liu Jiao , Bier Caide , Chenevert Madeline , Li Yuwen 
Published: January 2025

ABSTRACTRAC1 encodes the protein RAS‐related C3 Botulinum Toxin Substrate 1 (RAC1), which plays a pivotal role in various cellular functions. Pathogenic variants in RAC1 are linked to the rare intellectual developmental disorder, autosomal‐dominant 48 (MRD48). We present one case with typical phenotype and two cases with a mild phenotype. This report expands the phenotypic spectrum of MRD48.
Lubricant property evaluation of electrical conductive rice bran oil‐based lubricant with dioctyl ammonium oleate ionic liquid as an additive
Authors: Ajmal N. , Mohanan Visakh , Pavithran Rani , Rani S. , Thampi Ananthan D. , Sneha E. 
Published: January 2025

AbstractThe growing environmental consciousness and research into green lubricant technology in various industries has drawn a lot of attention to vegetable oils. The major negative aspect of vegetable oil is its poor oxidation stability. Recent research in ionic liquids (ILs) showed its potential as a base fluid and additive for lubricant applications. These are organic salts that dissolve at temperatures below 100°C. Among the potential characteristics of ILs are their non‐volatility, high oxidation stability, non‐flammability, and high conductivity to heat and electricity. The present study synthesized a protic ionic liquid named dioctyl ammonium oleate (DAO). The optimum DAO percentage in rice bran oil (RBO) was then optimized based on the tribological properties. The electrical conductivity and basic lubricant properties, such as physicochemical, oxidation stability, corrosion stability, thermal properties, and extreme pressure capability of the optimized RBO‐DAO blend were evaluated and compared with RBO. The developed RBO‐DAO blend shows the potential to be used as a base fluid for electrical conductive lubricants due to its significantly enhanced electrical conductivity, better oxidation stability, and superior tribological properties. The optimum DAO weight percentage in RBO is 2 wt%. The results show the potential of electrical conductive lubricant developed to enhance the performance of electrical equipment, reduce static electricity in industrial machinery, and prevent lubricant degradation in the presence of electric current. The components of electric vehicles, such as bearings, pads, seals, and gear, also require electrical conductive lubricants to avoid premature failure and electromagnetic interference problems. The developed lubricant can be considered a potential alternative in various industries such as automotive, renewable systems, medical devices, robotics, high‐speed machining, and so forth.
Development of UV‐Protective Hemp‐Based Eco‐Friendly Textiles
Authors: Duru Sena Cimilli , Candan Cevza , Nergis Banu 
Published: January 2025

ABSTRACTWhen exposed to UV rays, one of the rays emitted from the sun, for a certain period of time, it can harm the human body. Therefore, people should be protected from these harmful rays, especially children who are more sensitive need extra care as they often spend time outside. This study aimed to design an environmentally friendly seasonal outerwear fabric with high UV protection. To do so, the protection level of rib, half‐Milan, and full‐Milan fabrics manufactured from the yarns made of viscose, cotton, hemp and/or Refibra fiber mixtures is investigated. Additionally, a hybrid yarn feeding scheme is adopted, namely, feeding 4 ends of Ne 30/1 yarn and 2 ends of Ne 30/2 yarn, during knitting process in an attempt to have the benefit of various types of fibers and yarns involved. In the light of the results, an alternative rib‐based structure namely pique rib is developed by employing comparatively more miss stitches in the structure. Generally speaking, the UPF performance of the structures under discussion worsen as the percentage of cotton and/or viscose and Refibra fibers in the yarns increases. Furthermore, it is observed that the amount of the hemp fiber in the fabric is not influential on the UV‐blocking behavior of the fabrics. Finally, the structures knitted using the yarn feeding scheme composed of 4 ends of Ne 30/1 yarn have higher UPF performance than the others, and among all the structures the pique one exhibits the best performance so far as UV protection is concerned.
Environmental Friendly Polymer Based Recycled Nitrile Gloves Incorporated With Poly(Lactic Acid)/Graphene Nanoplatelets Binary Blends
Authors: Bijarimi Mohd , Jaro Vera Saban , Mulkiyan La Ode Muhammad Zuhdi , Mat Desa M. S. Z. , Normaya Erna , Ahmad Mohammad Norazmi 
Published: January 2025

ABSTRACTThe waste issue from the widespread use of nitrile gloves emphasize the environmental and health risks associated with improper disposal. This study introduces an innovative approach by incorporating recycled nitrile gloves made from acrylonitrile butadiene (rNBR) into a composite with poly(lactic acid) (PLA) and graphene nanoplatelets (GNPs) (1, 2, and 3 phr). The results showed a maximum improvement in mechanical properties at a PLA/rNBR blend ratio of 60:40 wt%, demonstrating a balance between stiffness and toughness compared to other binary blend ratios. The incorporation of GNP enhanced the values of Young's modulus, tensile strength, and elongation, respectively. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) recorded that the thermal stability of PLA/rNBR tends to increase with the loaded GNP. The morphological properties observed through scanning electron microscopy (SEM) revealed that the PLA/rNBR surface exhibited a nonhomogeneous distribution, leading to the formation of numerous voids and low adhesion. However, the good distribution of GNP within the matrix contributed to greater homogeneity, thereby reducing defects caused by rubber crumbs and voids in the PLA/rNBR fracture. Based on this research, this strategy offers a promising solution to address the environmental challenges posed by personal protective equipment waste.
Bioactivity and Mechanical Performance of Centrifugally Spun Poly(D,L‐Lactide)/Poly(3‐Hydroxybutyrate) Submicrometric Fibers Containing Zinc Oxide and Hydroxyapatite Nanostructures
Authors: Padilla‐Gainza Victoria , Rodríguez‐Tobías Heriberto , Lozano Karen , Rodríguez Cristóbal , Gilkerson Robert , Ledezma‐Pérez Antonio S. , Anaya‐Barbosa Narcedalia , Morales Graciela 
Published: January 2025

ABSTRACTThis study investigates the morphological, thermal, mechanical, and bioactive properties of centrifugally spun fibrous composites made from poly(D,L‐lactide)/poly(3‐hydroxybutyrate) (PLA/PHB) blends with zinc oxide (ZnO) and hydroxyapatite (Hap) nanoparticles. A 75/25 PLA/PHB weight ratio was chosen to balance mechanical and thermal properties. The precursor solution viscosities ranged from 0.25 to 0.50 Pa s, increasing with nanoparticle incorporation probably due to polymer‐nanoparticle interactions. SEM revealed a uniform fibrous morphology, with diameters of 1.21 for PLA/PHB, 2.65 for PLA/ZnO/Hap, and 1.80 μm for PLA/PHB/ZnO/Hap. TGA showed two‐step degradation for PLA/PHB fibers, while PLA/PHB/ZnO/Hap degraded in a single step at 249°C, leaving a residue of 9.95%. DSC indicated partial miscibility, with cold crystallization at 85°C (enthalpy: 7.72 J/g), slightly modified by nanoparticle addition. PLA/PHB fibers achieved a Young's modulus of 24.96 ± 3.91 MPa, three times that of pure PLA, but adding ZnO and Hap reduced modulus and tensile strength to 6.03 and 0.29 MPa, retaining suitability for biomedical applications. PLA/PHB/ZnO/Hap fibers exhibited 90% Escherichia coli growth inhibition and enhanced MC3T3‐E1 cell viability by 120% on day 7. These results highlight their potential for antimicrobial, biocompatible medical devices.
Stability analysis of switched Markov jump linear systems with hybrid switchings
Authors: Yu Qiang , Li Junzhou 
Published: January 2025

AbstractThis paper investigates the exponentially almost sure (EAS) stability of switched Markov jump linear systems (SMJLSs), which is subjected to deterministic switching and stochastic Markov jump switching. Using the ergodic law of large numbers, stability criteria for the SMJLS with all EAS stable or partially unstable sub‐Markov jump linear systems are established, where the deterministic switching is governed by a
‐dependent average dwell time approach. Some stability conditions under the average dwell time and mode‐dependent average dwell time (MDADT) deterministic switching are established as corollaries. Especially, the results of MDADT for SMJLS are given for the first time. Finally, three numerical examples are provided to illustrate the efficiency of the proposed results.