bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying periodic and anti-periodic boundary conditions in existence results of fractional differential equations via nonlinear contractive mappings
Authors: Panda Sumati Kumari , Vijayakumar Velusamy , Nisar Kottakkaran Sooppy 
Published: September 2023

AbstractWe introduce a notion of nonlinear cyclic orbital $(\xi -\mathscr{F})$
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where $$\begin{aligned} &\mathcal{L}(\mathcal{D})=\gamma _{w} \,{}^{c} \mathcal{D}^{\delta _{w}}+ \gamma _{w-1} \,{}^{c} \mathcal{D}^{\delta _{w-1}}+\cdots+\gamma _{1} \,{}^{c} \mathcal{D}^{\delta _{1}}+\gamma _{0} \,{}^{c} \mathcal{D}^{\delta _{0}},\\ &\gamma _{\flat}\in \mathbb{R}\quad (\flat =0,1,2,3,\ldots,w), \qquad \gamma _{w} \neq 0, \\ &0\leq \delta _{0}< \delta _{1}< \delta _{2}< \cdots< \delta _{w-1}< \delta _{w}< 1; \end{aligned}$$

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2. The nonlinear multi-term fractional delay differential equation $$\begin{aligned} &\mathcal{L}(\mathcal{D})\theta (\varsigma ) =\sigma \bigl(\varsigma , \theta ( \varsigma ),\theta (\varsigma -\tau ) \bigr), \quad \varsigma \in \mathscr{J}=[0, \mathscr{A}], \mathscr{A}>0; \\ &\theta (\varsigma ) =\bar{\sigma}(\varsigma ),\quad \varsigma \in [-\tau ,0], \end{aligned}$$

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where $$\begin{aligned} &\mathcal{L}(\mathcal{D})=\gamma _{w} \,{}^{c} \mathcal{D}^{\delta _{w}}+ \gamma _{w-1} \,{}^{c} \mathcal{D}^{\delta _{w-1}}+\cdots+\gamma _{1} \,{}^{c} \mathcal{D}^{\delta _{1}}+\gamma _{0} \,{}^{c} \mathcal{D}^{\delta _{0}},\\ &\gamma _{\flat}\in \mathbb{R}\quad (\flat =0,1,2,3,\ldots,w), \qquad \gamma _{w} \neq 0, \\ &0\leq \delta _{0}< \delta _{1}< \delta _{2}< \cdots< \delta _{w-1}< \delta _{w}< 1; \end{aligned}$$

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Prevalence of Strongyloides in Southeast Asia: a systematic review and meta-analysis with implications for public health and sustainable control strategies
Authors: Chan Abigail Hui En , Kusolsuk Teera , Watthanakulpanich Dorn , Pakdee Wallop , Doanh Pham Ngoc , Yasin Azlin Mohd , Dekumyoy Paron , Thaenkham Urusa 
Published: September 2023

Abstract
Background
Strongyloidiasis, caused by the nematodes Strongyloides stercoralis and Strongyloides fuelleborni, is estimated to affect over 600 million individuals worldwide. The disease is endemic in Southeast Asia, where a warm-humid climate and socio-economic conditions maintain the parasite’s life cycle and transmission. However, the current diagnostic methods may not be sufficiently sensitive, suggesting that the true prevalence of strongyloidiasis could be seriously underestimated in this. This study aims to determine the prevalence of strongyloidiasis in Southeast Asia through a systematic review and meta-analysis and to discuss the implications of the estimated prevalence on diagnostic approaches and control strategies.

Methods
Following PRISMA guidelines, we conducted a systematic literature search in PubMed and Google Scholar databases to identify studies reporting Strongyloides prevalence data in the 11 Southeast Asian countries up to December 2022. A random effects model was employed to estimate the pooled prevalence of S. stercoralis at both regional and country levels.

Results
Out of 3722 articles identified, 224 met our inclusion criteria. For S. stercoralis specifically, we found 187 articles, of which 52.4% were from Thailand. All Southeast Asian countries, except Brunei, had at least one study on Strongyloides prevalence. The estimated pooled prevalence of S. stercoralis regionally was 12.7% (95% CI 10.70–14.80%), ranging from 0.4 to 24.9% at the country level. Cambodia had the highest pooled prevalence (24.9%, 95% CI 15.65–35.38%), followed by Lao PDR (16.5%, 95% CI 9.50–24.95%). Moreover, we obtained a pooled prevalence of 10% (95% CI 7.06–13.52%) in a group comprising immigrants, workers, and veterans from Southeast Asian countries. S. stercoralis infects various host types, including nonhuman primates, domestic dogs and cats, rodents, and transport carriers such as cockroaches and vegetables.

Conclusions
A high prevalence of strongyloidiasis in Southeast Asia was revealed, highlighting the importance of the region’s ongoing research, surveillance, and control efforts. Factors contributing to the strongyloidiasis transmission include the role of animal hosts, the impact of global connectivity, and the significance of the co-endemicity of other Strongyloides species. Based on these findings, a multi-pronged One-Health approach is essential for sustainable intervention and control.
Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation
Authors: Toskov Vasil , Ehl Stephan 
Published: September 2023

AbstractMany inborn errors of immunity (IEI) manifest with hallmarks of both immunodeficiency and immune dysregulation due to uncontrolled immune responses and impaired immune homeostasis. A subgroup of these disorders frequently presents with autoimmunity and lymphoproliferation (ALPID phenotype). After the initial description of the genetic basis of autoimmune lymphoproliferative syndrome (ALPS) more than 20 years ago, progress in genetics has helped to identify many more genetic conditions underlying this ALPID phenotype. Among these, the majority is caused by a group of autosomal-dominant conditions including CTLA-4 haploinsufficiency, STAT3 gain-of-function disease, activated PI3 kinase syndrome, and NF-κB1 haploinsufficiency. Even within a defined genetic condition, ALPID patients may present with staggering clinical heterogeneity, which makes diagnosis and management a challenge. In this review, we discuss the pathophysiology, clinical presentation, approaches to diagnosis, and conventional as well as targeted therapy of the most common ALPID conditions.
Gamma camera-specific reference standards for radioactive iodine uptake measurements
Authors: Mourik Jurgen E. M. , Derks Mark , te Beek Erik T. , ten Broek Marc R. J. 
Published: September 2023

Abstract
Background
Current guidelines of the radioiodine uptake (RAIU) test allow the use of different equipment, isotopes, activity and region-of-interest (ROI). We evaluated presence and extent of these differences in clinical practice and evaluated the effect of some of these variations on RAIU outcomes. Also, gamma camera-specific reference standards were calculated and retrospectively compared with measurements obtained during clinical RAIU tests.

Materials and methods
First, questionnaires were sent to Dutch nuclear medicine departments requesting information about equipment usage, isotope, isotope formulation, activity and measurement techniques. Secondly, a neck phantom containing a range of activities in capsule or water-dissolved formulation was scanned. Counts were measured using automatic ROI, square box ROI or all counts in the image. Thirdly, clinical RAIU data were collected during 2015–2018 using three different gamma cameras. Reference standards for each scanner were calculated using regression analysis between reference activity and measured counts. Uptake measurements using this gamma camera-specific reference standard were compared with original measurements.

Results
The survey demonstrated significant differences in isotope, isotope formulation, activity, use of neck phantoms, frequency and duration of reference measurements, distance to collimator, use of background measurements and ROI delineation. The phantom study demonstrated higher counts for the water-dissolved formulation than capsules using both automatic and square box ROI. Also, higher counts were found using a square box ROI than an automatic ROI. The retrospective study showed feasibility of RAIU calculations using camera-specific reference standards and good correlation with the original RAIU measurements.

Conclusions
This study demonstrated considerable technical variation in RAIU measurement in clinical practice. The phantom study demonstrated that these differences could result in differences in count measurements, potentially resulting in different dose calculations for radioactive iodine therapy. Retrospective data suggest that camera-specific reference standards may be used instead of individual reference measurements using separate activity sources, which may thus eliminate some sources of variation.
Cardiometabolic healthcare for men with prostate cancer: an MD Anderson Cancer Center experience
Authors: Hahn Andrew W. , Thoman Whittney , Koutroumpakis Efstratios , Abdulla Amer , Subudhi Sumit K. , Aparicio Ana , Basen-Enngquist Karen , Logothetis Christopher J. , Gilchrist Susan C. 
Published: September 2023

Abstract
Background
Men diagnosed with prostate cancer are at risk for competing morbidity and mortality due to cardiometabolic disease given their advanced age at diagnosis, high prevalence of pre-existing risk factors, and receipt of systemic therapy that targets the androgen receptor (AR). Expert panels have stressed the importance of cardiometabolic risk assessment in the clinic and proposed evaluating key risks using consensus paradigms. Yet, there is a gap in real-world evidence for implementation of comprehensive cardiometabolic care for men with prostate cancer.

Methods
This is a retrospective, descriptive study of patients with prostate cancer who were referred and evaluated in the Healthy Heart Program at MD Anderson Cancer Center, which was established to mitigate cardiometabolic risks in men with prostate cancer. Patients were seen by a cardiologist and exercise physiologist to evaluate and manage cardiometabolic risk factors, including blood pressure, cholesterol, blood glucose, tobacco use, and coronary artery disease, concurrent with management of their cancer by a medical oncologist.

Results
From December 2018 through October 2021, the Healthy Heart Program enrolled 55 men with prostate cancer, out of which 35 had biochemical, locoregional recurrence or distant metastases, while all received at least a single dose of a luteinizing hormone-releasing hormone (LHRH) analog. Ninety-three percent of men were overweight or obese, and 51% had an intermediate or high risk of atherosclerotic cardiovascular disease at 10 years based on the pooled cohort equation. Most men had an overlap of two or more cardiometabolic diseases (84%), and 25% had an overlap of at least 4 cardiometabolic diseases. Although uncontrolled hypertension and hyperlipidemia were common among the cohort (45% and 26%, respectively), only 29% of men followed up with the clinic.

Conclusions
Men with prostate cancer have a high burden of concurrent cardiometabolic risk factors. At a tertiary cancer center, the Healthy Heart Program was implemented to address this need, yet the utility of the program was limited by poor follow-up possibly due to outside cardiometabolic care and inconvenient appointment logistics, a lack of cardiometabolic labs at the time of visits, and telemedicine visits.
Anesthetic management of inguinal hernia in an ex-premature infant with subglottic stenosis: a case report
Authors: Doi Yumi , Ekuni Satoshi 
Published: September 2023

Abstract
Background
We report the anesthetic management of inguinal hernia repair for an infant with subglottic stenosis. A previously scheduled operation had been cancelled due to unexpected airway trouble during the induction.

Case presentation
A boy was born at 24 weeks of gestation and his trachea was intubated for 45 days. At 16 months old, surgery for inguinal hernia was planned, but cancelled due to unexpected narrow airway, and subglottic stenosis was first suspected. At 17 months old, he was transferred to us for inguinal hernia surgery. After careful discussion between the surgical team and the anesthesiologists, a strategy to manage this patient was developed. He underwent open hernia surgery under spinal anesthesia and diagnostic rigid bronchoscopy under tubeless general anesthesia separately, which revealed low-grade stenosis and some subglottic cysts. The postoperative course was uneventful.

Conclusion
Interdepartmental discussion weighing risks and benefits may deduce the safest and most appropriate anesthesia method.
Tolerability and Efficacy of the Anticluster of Differentiation 47 Antibody Magrolimab Combined With Azacitidine in Patients With Previously Untreated AML: Phase Ib Results
Authors: Daver Naval G. , Vyas Paresh , Kambhampati Suman , Al Malki Monzr M. , Larson Richard A. , Asch Adam S. , Mannis Gabriel , Chai-Ho Wanxing , Tanaka Tiffany N. , Bradley Terrence J. , Jeyakumar Deepa , Wang Eunice S. , Sweet Kendra , Kantarjian Hagop M. , Garcia-Manero Guillermo , Komrokji Rami , Xing Guan , Ramsingh Giridharan , Renard Camille , Zeidner Joshua F. , Sallman David A. 
Published: September 2023

PURPOSE Magrolimab is a first-in-class humanized monoclonal antibody against cluster of differentiation 47, an antiphagocytic signal used by cancer cells to evade phagocytosis. Azacitidine upregulates prophagocytic signals on AML cells, further increasing phagocytosis when combined with magrolimab. We report final phase Ib data for magrolimab with azacitidine in patients with untreated AML ineligible for intensive chemotherapy (ClinicalTrials.gov identifier: NCT03248479 ). PATIENTS AND METHODS Patients with previously untreated AML, including TP53-mutant AML, received magrolimab intravenously as an initial dose (1 mg/kg, days 1 and 4), followed by 15 mg/kg once on day 8 and 30 mg/kg once weekly or every 2 weeks as maintenance. Azacitidine 75 mg/m2 was administered intravenously/subcutaneously once daily on days 1-7 of each 28-day cycle. Primary end points were safety/tolerability and proportion with complete remission (CR). RESULTS Eighty-seven patients were enrolled and treated; 72 (82.8%) had TP53 mutations with a median variant allele frequency of 61% (range, 9.8-98.7). Fifty-seven (79.2%) of TP53-mutant patients had European LeukemiaNet 2017 adverse-risk cytogenetics. Patients received a median of 4 (range, 1-39) cycles of treatment. The most common treatment-emergent adverse events included constipation (49.4%), nausea (49.4%), and diarrhea (48.3%). Thirty (34.5%) experienced anemia, and the median hemoglobin change from baseline to first postdose assessment was –0.9 g/dL (range, –3.6 to 2.5 g/dL). Twenty-eight (32.2%) patients achieved CR, including 23 (31.9%) patients with TP53 mutations. The median overall survival in TP53-mutant and wild-type patients were 9.8 months and 18.9 months, respectively. CONCLUSION Magrolimab with azacitidine was relatively well tolerated with promising efficacy in patients with AML ineligible for intensive induction chemotherapy, including those with TP53 mutations, warranting further evaluation of magrolimab with azacitidine in AML. The phase III randomized ENHANCE-2 (ClinicalTrials.gov identifier: NCT04778397 ) and ENHANCE-3 (ClinicalTrials.gov identifier: NCT05079230 ) studies are recruiting frontline patients with AML.
TRβ Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice
Authors: Gillis Noelle E , Cozzens Lauren M , Wilson Emily R , Smith Noah M , Tomczak Jennifer A , Bolf Eric L , Carr Frances E 
Published: September 2023

Abstract
Thyroid hormone receptor beta (TRβ) is a recognized tumor suppressor in numerous solid cancers. The molecular signaling of TRβ has been elucidated in several cancer types through re-expression models. Remarkably, the potential impact of selective activation of endogenous TRβ on tumor progression remains largely unexplored. We used cell-based and in vivo assays to evaluate the effects of the TRβ agonist sobetirome (GC-1) on a particularly aggressive and dedifferentiated cancer, anaplastic thyroid cancer (ATC). Here we report that GC-1 reduced the tumorigenic phenotype, decreased cancer stem-like cell populations, and induced redifferentiation of the ATC cell lines with different mutational backgrounds. Of note, this selective activation of TRβ amplified the effects of therapeutic agents in blunting the aggressive cell phenotype and stem cell growth. In xenograft assays, GC-1 alone inhibited tumor growth and was as effective as the kinase inhibitor, sorafenib. These results indicate that selective activation of TRβ not only induces a tumor suppression program de novo but enhances the effectiveness of anticancer agents, revealing potential novel combination therapies for ATC and other aggressive solid tumors.
“In Accord with the Spirit of American Democracy”: Tracing the Network of the US Armed Services Editions
Authors: Muenchrath Anna 
Published: September 2023

Abstract
This essay explores the possibilities of thinking about the production, circulation, and reception of books through the form of the network. Using archival material of the Council of Books in Wartime, the essay reassembles some of the many attachments that formed the Armed Services Editions during World War II, one of the largest enterprises in the history of publishing. The essay traces the selections of the council, the networks of soldier-readers created by the books themselves, and the acts of reading constrained and made possible by these attachments across front lines and through bureaucratic memos. This assembly provides the backdrop for a consideration of the text of Thomas Mann’s “Mario and the Magician,” a short story published in the Armed Services Editions in 1944, whose plot not only mirrors the tension between authority and free will manifested in the geopolitical conflict of World War II, but also elucidates the dialectic of power and agency modeled by the form of the network as articulated in the council’s reader-producing experiment itself. What is ultimately at stake in positing an uneven network of actors who negotiate, maintain, extend, and possibly even subvert vectors of cultural power is a reconsideration of the agency attributed to readers in sociological studies of literature.
Reflexivity’s Ontological Turn: From Cybernetics to Autopoiesis in “The Circular Ruins” and The People of Paper
Authors: Martinson T. J. 
Published: September 2023

Abstract
While postmodern metafiction (or reflexive fiction) is commonly positioned outside the scope of the Ontological Turn due to metafiction’s association with postmodernism’s insistence on “world as text,” this article argues that metafiction’s proximity to scientific theories of reflexivity engenders a shift toward what the article calls body as text, a shift that is synchronous with reflexivity’s evolution from cybernetics to biological autopoiesis. To trace metafiction’s aesthetic evolution from world as text to body as text, the article examines Jorge Luis Borges’s short story “The Circular Ruins” (1940) alongside early-order cybernetic theories of reflexivity before examining Salvador Plascencia’s The People of Paper (2005) alongside later theories of biological autopoiesis. While both narratives demonstrate an interest in the world-building powers of the text, the article argues that Plascencia’s novel demonstrates reflexivity’s autopoietic ability to examine the interstitial relationship between material embodiment and nonhuman agencies. By moving away from Borgesian self-regulation toward self-assembly, The People of Paper gradually sheds the epistemological preoccupations of its world-as-text aesthetic in favor a more ontological body-as-text aesthetic, thereby opening up the possibility of interpreting Plascencia’s novel as an aestheticization not of the construction of reality but of the construction of the body itself. In marking a distinction between world-as-text metafiction and body-as-text metafiction, the latter emerges as a uniquely useful heuristic in the Ontological Turn for modeling molecular embodiment and nonhuman agency.
Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells
Authors: Sathiyaseelan Paalini , Chittaranjan Suganthi , Kalloger Steve E. , Chan Jennifer , Go Nancy E. , Jardon Mario A. , Ho Cally J. , Hui Theodore , Xu Jing , Chow Christine , Gao Dongxia , Johnson Fraser D. , Lockwood William W. , Morin Gregg B. , Renouf Daniel J. , Schaeffer David F. , Gorski Sharon M. 
Published: September 2023

ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) exhibits elevated levels of autophagy, which promote tumor progression and treatment resistance. ATG4B is an autophagy-related cysteine protease under consideration as a potential therapeutic target, but it is largely unexplored in PDAC. Here, we investigated the clinical and functional relevance of ATG4B expression in PDAC. Using two PDAC patient cohorts, we found that low ATG4B mRNA or protein expression is associated with worse patient survival outcomes, poorly differentiated PDAC tumors and a lack of survival benefit from adjuvant chemotherapy. In PDAC cell lines, ATG4B knockout reduced proliferation, abolished processing of LC3B (also known as MAP1LC3B), and reduced GABARAP and GABARAPL1 levels, but increased ATG4A levels. ATG4B and ATG4A double knockout lines displayed a further reduction in proliferation, characterized by delays in G1-S phase transition and mitosis. Pro-LC3B accumulated aberrantly at the centrosome with a concomitant increase in centrosomal proteins PCM1 and CEP131, which was rescued by exogenous ATG4B. The two-stage cell cycle defects following ATG4B and ATG4A loss have important therapeutic implications for PDAC.