bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the protective efficacy of Olyset®Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial
Authors: Kagaya Wataru , Chan Chim W. , Kongere James , Kanoi Bernard N. , Ngara Mtakai , Omondi Protus , Osborne Ashley , Barbieri Laura , Kc Achyut , Minakawa Noboru , Gitaka Jesse , Kaneko Akira 
Published: May 2023

Abstract
Background
In the Lake Victoria Basin of western Kenya, malaria remains highly endemic despite high coverage of interventions such as insecticide-impregnated long-lasting insecticidal nets (LLIN). The malaria-protective effect of LLINs is hampered by insecticide resistance in Anopheles vectors and its repurposing by the community. Ceiling nets and LLIN with synergist piperonyl butoxide (PBO-LLIN) are novel tools that can overcome the problems of behavioral variation of net use and metabolic resistance to insecticide, respectively. The two have been shown to reduce malaria prevalence when used independently. Integration of these two tools (i.e., ceiling nets made with PBO-LLIN or Olyset®Plus ceiling nets) appears promising in further reducing the malaria burden.

Methods
A cluster-randomized controlled trial is designed to assess the effect of Olyset®Plus ceiling nets on reducing malaria prevalence in children on Mfangano Island in Homa Bay County, where malaria transmission is moderate. Olyset®Plus ceiling nets will be installed in 1315 residential structures. Malaria parasitological, entomological, and serological indicators will be measured for 12 months to compare the effectiveness of this new intervention against conventional LLIN in the control arm.

Discussion
Wider adoption of Olyset®Plus ceiling nets to complement existing interventions may benefit other malaria-endemic counties and be incorporated as part of Kenya’s national malaria elimination strategy.

Trial registration
UMIN Clinical Trials Registry UMIN000045079. Registered on 4 August 2021.
Differences in adoption of COVID-19 pandemic related preventive behaviour by viral load suppression status among people living with HIV during the first wave of the pandemic
Authors: Folayan Morenike Oluwatoyin , Abeldaño Zuñiga Roberto Ariel , Aly Nourhan M. , Ellakany Passent , Idigbe Ifeoma E. , Jafer Mohammed , Lawal Folake B. , Khalid Zumama , Lusher Joanne , Virtanen Jorma I. , Nguyen Annie L 
Published: May 2023

Abstract
Background
Adherence to antiretroviral therapy and COVID-19 preventive behaviours among people living with HIV during the pandemic has received little attention in the literature. To address this gap in knowledge, the present study assessed the associations between viral load, adherence to antiretroviral therapy and the use of COVID-19 prevention strategies during the first wave of the COVID-19 pandemic. This was a secondary analysis of data generated through an online survey recruiting participants from 152 countries. Complete data from 680 respondents living with HIV were extracted for this analysis.

Results
The findings suggest that detectable viral load was associated with lower odds of wearing facemasks (AOR: 0.44; 95% CI:0.28–0.69; p < 0.01) and washing hands as often as recommended (AOR: 0.64; 95% CI: 0.42–0.97; p = 0.03). Also, adherence to the use of antiretroviral drugs was associated with lower odds of working remotely (AOR: 0.60; 95% CI: 0.38–0.94; p = 0.02). We found a complex relationship between HIV positive status biological parameters and adherence to COVID-19 preventive measures that may be partly explained by risk-taking behaviours. Further studies are needed to understand the reasons for the study findings.
Using a technology acceptance model to determine factors influencing continued usage of mobile money service transactions in Ghana
Authors: Kelly Afful Ekow , Palaniappan Sellappan 
Published: May 2023

AbstractInvestigating and exploring factors influencing the continued usage and acceptance of mobile money transaction services in Ghana. The study employed the Technology Acceptance Model (TAM) with 406 mobile money users from Ghana's Savannah and Bono regions. According to the study, perceived risk perceived cost, social influence, perceived usefulness and ease of use had repercussions on users’ attitudes which influenced users' final decision to continue to use mobile money services in Ghana. The social influence positively impacted users through social networking in pushing the adoption and continued usage of mobile money services in the study area. However, the construct of Perceived trust had a positive impact on users’ decisions resulting in their negative attitude to mobile money services.
Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy
Authors: Bang Chaeeun , Park Min Gyu , Cho In Kyung , Lee Da-Eun , Kim Gye Lim , Jang Eun Hyang , Shim Man Kyu , Yoon Hong Yeol , Lee Sangmin , Kim Jong-Ho 
Published: May 2023

Abstract

Background

Claudin-4 (CLDN4), a tight junction protein, is overexpressed in several types of cancer, and is considered a biomarker for cancer-targeted treatment. CLDN4 is not exposed in normal cells, but becomes accessible in cancer cells, in which tight junctions are weakened. Notably, surface-exposed CLDN4 has recently been found to act as a receptor for
Clostridium perfringens
enterotoxin (CPE) and fragment of CPE (CPE17) that binds to the second domain of CLDN4.

Methods
Here, we sought to develop a CPE17-containing liposome that targets pancreatic cancers through binding to exposed CLDN4.

Results
Doxorubicin (Dox)-loaded, CPE17-conjugated liposomes (D@C-LPs) preferentially targeted CLDN4-expressing cell lines, as evidenced by greater uptake and cytotoxicity compared with CLDN4-negative cell lines, whereas uptake and cytotoxicity of Dox-loaded liposomes lacking CPE17 (D@LPs) was similar for both CLDN4-positive and negative cell lines. Notably, D@C-LPs showed greater accumulation in targeted pancreatic tumor tissues compared with normal pancreas tissue; in contrast, Dox-loaded liposomes lacking CPE17 (D@LPs) showed little accumulation in pancreatic tumor tissues. Consistent with this, D@C-LPs showed greater anticancer efficacy compared with other liposome formulations and significantly extended survival.

Conclusions
We expect our findings will aid in the prevention and treatment of pancreatic cancer and provide a framework for identifying cancer-specific strategies that target exposed receptors.

Graphical Abstract
An improved whale optimization algorithm for the model order reduction of large-scale systems
Authors: Butti Dasu , Mangipudi Sivakumar , Rayapudi Srinivasarao , Buddi Madhu Kiran , Kaniganti Kalyan Raj , Chittajallu Trinayani , Dontu Bhavana Rushi , Dunna Vijay Arun , Boni RamaKrishna , Kothuri Chenchu Kishore Kumar 
Published: May 2023

AbstractAn improved whale optimization algorithm (IWOA) is developed for the model order reduction (MOR) of large-scale systems (LSS) in this paper. An equivalent reduced order model (ROM) for the higher-order system (HOS) is derived by considering integral square error (ISE) as the objective function using IWOA. Many practical systems of single-input and single-output (SISO) and multi-input and multi-output (MIMO) systems are considered to examine the worth of the proposed technique. The powerfulness and robustness of the proposed design technique are tested on various typical examples. Several simulation results have been reported to demonstrate the efficacy of IWOA. To prove the potentiality of the suggested technique, the results have been compared with the familiar classical MOR techniques as well as other heuristic algorithms available in the literature.
Efficacy of combined sialendoscopic-assisted surgery in management of submandibular sialolithiasis: a systematic review
Authors: Askoura Anas Mohammed , Youssef Tamer Ali , Elgabry Passent Mostafa , Nassif Mena Maher 
Published: May 2023

Abstract
Background
The introduction of sialendoscopy has been a major step forward in providing an accurate means of diagnosing and locating submandibular sialolithiasis, also in permitting minimally invasive surgical treatment that can successfully manage those stones aiming for gland preservation.

Methods
We conducted a systemic review to assess the efficacy and safety of combined sialendoscopic assisted surgery in the management of submandibular sialolithiasis. This study included published medical articles from 2000 till 2022 concerning the efficacy and safety of combined sialendoscopic-assisted surgery in management of submandibular sialolithiasis searching Medline database (PubMed), Web of Science, Springer, Cochrane library, EMBASE. Fifteen articles met the inclusion criteria and were reviewed and analyzed.

Results
The success rate of combined sialendoscopic assisted surgery in management of submandibular sialolithiasis is 0.955% with 95% CI: (91.4% to 98.5). The overall percentage of sialadenectomy cases in the included studies is 2%. The overall percentage of complications in the included studies is 8%.

Conclusion
Combined sialendoscopic-assisted surgery is efficient and safe in management of submandibular sialolithiasis.
Multi-party simultaneous quantum identity authentication based on Greenberger-Horne-Zeilinger states
Authors: Wang Xing-Fu , Gu Shi-Pu , Sheng Yu-Bo , Zhou Lan 
Published: May 2023

AbstractA successful implementation of any secure communication protocols requires the identity authentication as a prerequisite. Quantum identity authentication (QIA) can ensure the unconditional security of identity code. In this paper, we propose a multi-party simultaneous quantum identity authentication (MSQIA) protocol based on the Greenberger-Horne-Zeilinger (GHZ) state. In the protocol,Ncertified users can directly send their identity codes to the authenticator Alice simultaneously through quantum channels without classical communication, which enables Alice to authenticate their identity at the same time. Our protocol only requires Alice to perform the single-photon measurement. In theory, this protocol is unconditionally secure and one pair of (N + 1)-photon GHZ state can transmitNbits of identity codes. Our MSQIA protocol has application potential in the quantum communication field in the near future.
CRISPR-Cas tools to study gene function in cytokinesis
Authors: Husser Mathieu C. , Skaik Noha , Martin Vincent J. J. , Piekny Alisa 
Published: May 2023

ABSTRACT
Cytokinesis is the process that separates a cell into two daughter cells at the end of mitosis. Most of our knowledge of cytokinesis comes from overexpression studies, which affects our interpretation of protein function. Gene editing can circumvent this issue by introducing functional mutations or fluorescent probes directly into a gene locus. However, despite its potential, gene editing is just starting to be used in the field of cytokinesis. Here, we discuss the benefits of using gene editing tools for the study of cytokinesis and highlight recent studies that successfully used CRISPR-Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) technology to answer critical questions regarding the function of cytokinesis proteins. We also present methodologies for editing essential genes and discuss how CRISPR interference (CRISPRi) and activation (CRISPRa) can enable precise control of gene expression to answer important questions in the field. Finally, we address the need for gene editing to study cytokinesis in more physiologically relevant contexts. Therefore, this Review provides a roadmap for gene editing to be used in the study of cytokinesis and other cellular processes.
Linking muscle mechanics to the metabolic cost of human hopping
Authors: Jessup Luke N. , Kelly Luke A. , Cresswell Andrew G. , Lichtwark Glen A. 
Published: May 2023

ABSTRACT
Many models have been developed to predict metabolic energy expenditure based on biomechanical proxies of muscle function. However, current models may only perform well for select forms of locomotion, not only because the models are rarely rigorously tested across subtle and broad changes in locomotor task but also because previous research has not adequately characterised different forms of locomotion to account for the potential variability in muscle function and thus metabolic energy expenditure. To help to address the latter point, the present study imposed frequency and height constraints to hopping and quantified gross metabolic power as well as the activation requirements of medial gastrocnemius (MG), lateral gastrocnemius (GL), soleus (SOL), tibialis anterior (TA), vastus lateralis (VL), rectus femoris (RF) and biceps femoris (BF), and the work requirements of GL, SOL and VL. Gross metabolic power increased with a decrease in hop frequency and increase in hop height. There was no hop frequency or hop height effect on the mean electromyography (EMG) data of ankle musculature; however, the mean EMG of VL and RF increased with a decrease in hop frequency and that of BF increased with an increase in hop height. With a reduction in hop frequency, GL, SOL and VL fascicle shortening, fascicle shortening velocity and fascicle to MTU shortening ratio increased, whereas with an increase in hop height, only SOL fascicle shortening velocity increased. Therefore, within the constraints that we imposed, decreases in hop frequency and increases in hop height resulted in increases in metabolic power that could be explained by increases in the activation requirements of knee musculature and/or increases in the work requirements of both knee and ankle musculature.
Catheter-based therapies and short-term outcomes in the oncological patients with acute inferior vena cava thrombosis: a single centre experience
Authors: Gong Maofeng , Jiang Rui , Liu Zhengli , Zhao Boxiang , Kong Jie , He Xu , Gu Jianping 
Published: May 2023

Objective: To investigate the safety and effectiveness of catheter-based therapy (CBT) using AngioJet rheolytic thrombectomy (ART) device or large lumen catheter (LLC) in the oncological patients with inferior vena cava thrombosis (IVCT). Methods: This was a retrospective study including eligible patients with IVCT treated with CBT coupled with dose-reduced thrombolysis as the first-line treatment from February 1, 2015 to January 1, 2022. The baseline demographics, comorbidities, clinical characteristics, treatment details, course data were all reviewed. Results: A total of 33 patients (mean age 58.8 years, 57.6% male) was included, of whom 17 patients underwent ART and 16 underwent LLC aspiration, the technical success rates were 100%. All patients subsequently underwent catheter-directed thrombolysis relative to reduced-dose thrombolysis. At the end of catheter-directed thrombolysis, clinical success was achieved in 26 (78.8%) patients. In the subgroup analysis, ART seemed to receive a slightly higher rate of thrombus removal Grade III (47.1% vs 12.5%, p = .057). The symptoms of leg pain and swelling post-treatment were significantly improved in both groups (p < .001). Except for transient macroscopic hemoglobinuria occurring in patients with ART, none of all patients suffered from procedure-related adverse events and major complications. Minor complications such as bleeding events occurred in 6.1% (2/33) of patients. At the 6 month follow-up, the incidence of recurrent thrombosis and mild post-thrombotic syndrome (PTS) were 9.7% (3/31) and 6.5% (2/31). Conclusion: CBT is a safe and effective modality for the management of IVCT in the oncological patients, leading to high levels of technical and clinical success, symptoms alleviation, as well as a low incidence of minor complication, mild PTS and recurrence. Advances in knowledge statement: The available data and evidence of endovascular therapy (ET) on oncologic patients with IVCT remains insufficient. The purpose of present single center retrospective study including 33 oncological patients is to investigate the preliminary safety and efficacy of CBT using ART device or LLC. The results demonstrated that CBTs are safe and effective as an ET modality in majority of eligible patients with symptomatic acute cancer-associated IVCT, indicating high levels of technical and clinical success, symptoms alleviation, as well as a low prevalence of minor complication, mild post-thrombotic syndrome and recurrence. Furthermore, they have the advantages of accelerated reduction of thrombus burden in a moderate time, speedy restoration of blood flow, but at the risk of potentially increased economic cost. Notably, in the condition of parallel time and dosages of lytic agents, ART tends to achieve a slightly higher thrombus removal Grade III than LLCA.
Assessment of the frequency of consumption of selected food products by territory defense soldiers, depending on nutritional knowledge in the context of a healthy lifestyle
Authors: Łoboda Dorota 
Published: May 2023

Introduction:
The problem of rational, proper nutrition that ensures the body's proper performance and quality of work is of particular importance in the army. This is related to the specificity of military service, with a significant physical and mental burden, and this makes it very important to properly meet the nutritional needs of young soldiers, significantly affecting combat ability and mental toughness. The aim of the article is to analyze the frequency of consumption of selected food products and to evaluate the lifestyle of soldiers of the territorial defense forces
Objective:
The aim of the study was to assess the frequency of consumption of food products by soldiers of the territorial defense forces in connection with lifestyle.
Material and methods:
The study was conducted among 100 male soldiers of the Territorial Defense Forces, using the KomPAN questionnaire for examining views and eating habits for people aged 16 to 65, from which part B concerning the frequency of food consumption and part C related to lifestyle were selected for the study.

Results:
With age, the percentage of surveyed soldiers who were found to be overweight increased, while the percentage of soldiers maintaining a normal body weight decreased. In the diet of soldiers there are too few vegetables, fruits and fish, while white bread and sweetened drinks appear too often. The surveyed group believes that the level of their nutritional knowledge is insufficient, while the majority declare that their nutrition is correct
Conclusions:
Based on the conducted research, it appears that soldiers should continue to be trained and the basic knowledge about proper nutrition should be systematized, including the nutritional prevention of diet-related diseases of civilization. The specificity and requirements of a given military service as well as the soldier's individual health condition should be taken into account.
Combining Choice and Response Time Data: A Drift-Diffusion Model of Mobile Advertisements
Authors: Xiang Chiong Khai , Shum Matthew , Webb Ryan , Chen Richard 
Published: May 2023

Endogenous response time data are increasingly becoming available to applied researchers of economic choices. However, the usefulness of such data for preference estimation is unclear. Here, we adapt a sequential sampling model—previously validated to jointly explain subjects’ choices and response times in laboratory experiments—to model users’ responses to video advertisements on mobile devices in a field setting. Our estimates of utility correlate positively with out-of-sample measures of ad engagement, thus providing external validation of the value of incorporating endogenous response time information into a choice model. We then use the model estimates to assess the effectiveness of manipulating attention toward an advertisement at the beginning of a decision. Counterfactual simulations predict that making an ad “nonskippable” (requiring users to watch some portion of the ad)—as is the practice of some online platforms (e.g., YouTube)—generates only modest increases in click-through rates and revenue. This paper was accepted by David Simchi-Levi, behavioral economics and decision analysis. Funding: R. Webb work was supported by Social Sciences and Humanities Research Council [Grant 430-2019-00246]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4738 .
The mediating role of resilience on the association between family satisfaction and lower levels of depression and anxiety among Chinese adolescents
Authors: Ye Beizhu , Lau Joseph T. F. , Lee Ho Hin , Yeung Jason C. H. , Mo Phoenix K. H. 
Published: May 2023

Purpose
This study aimed to explore the association between family satisfaction, resilience, and anxiety and depression among adolescents, and the mediating role of resilience in these relationships.

Methods
A cross-sectional study was conducted among grade 8 to 9 students from 4 secondary schools in Hong Kong. A total of 1,146 participants completed the survey.

Results
Respectively 45.8% and 58.0% of students scored above the cut-off for mild anxiety and mild depression. Results from linear regression analyses showed that family satisfaction was positively associated with resilience, and both family satisfaction and resilience were and negatively associated with anxiety and depression. The mediating effects of resilience on the relationship between family satisfaction and anxiety/ depression (26.3% and 31.1% effects accounted for, respectively) were significant.

Conclusions
Both family satisfaction and resilience have important influence on adolescent mental health. Interventions that seek to promote positive family relationships and resilience of adolescents may be effective in preventing and reducing anxiety and depression symptoms among adolescents.
Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm
Authors: Tedjawirja V. N. , Mieremet A. , Rombouts K. B. , Yap C. , Neele A. E. , Northoff B. H. , Chen H. J. , Vos M. , Klaver D. , Yeung K. K. , Balm R. , de Waard V. 
Published: May 2023

Introduction
Follicle stimulating hormone (FSH) is identified to play a role in postmenopausal disease and hypothesized to affect abdominal aortic aneurysm (AAA) onset/progression in postmenopausal women. We aimed to detect FSHR gene expression in AAA tissue and cell types involved in AAA formation.

Methods
FSH stimulation of human umbilical cord endothelial cells (HUVECs), smooth muscle cells (HUCs) and PMA-differentiated macrophages to assess gene expression of FSHR and various markers. Human macrophages activated with various stimuli were assessed for FSHR gene expression. AAA dataset, AAA tissue samples and AAA-derived smooth muscle cells (SMC) obtained from elderly female donors were assessed for FSHR gene expression. AAA-SMCs were stimulated with FSH to assess its effect on gene expression. Lastly, oxidized low-density-lipoprotein (ox-LDL) uptake and abundance of cell surface protein markers were assessed by flow cytometry after FSH stimulation of human monocytes.

Results
FSH stimulation showed similar levels of gene expression in HUVECs and HUCs. Only ACTA2 was downregulated in HUCs. In PMA-differentiated macrophages, gene expression of inflammation markers was unchanged after FSH stimulation. FSHR gene expression was found to be low in the AAA datasets. Female AAA-SMCs show occasional FSHR gene expression at a very low level, yet stimulation with FSH did not affect gene expression of SMC- or inflammation markers. FSH stimulation did not impact ox-LDL uptake or alter cell surface protein expression in monocytes. While FSHR gene expression was detected in human testis tissue, it was below quantification level in all other investigated cell types, even upon activation of macrophages with various stimuli.

Conclusion
Despite previous reports, we did not detect FSHR gene expression in various extragonadal cell types, except in occasional female AAA-SMCs. No clear effect on cell activation was observed upon FSH stimulation in any cell type. Our data suggest that a direct effect of FSH in AAA-related extragonadal cells is unlikely to influence AAA.