bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic syndrome is associated with breast cancer mortality: A systematic review and meta‐analysis
Authors: Harborg Sixten , Larsen Helene Borup , Elsgaard Stine , Borgquist Signe 
Published: January 2025

AbstractBackgroundThis systematic review and meta‐analysis assesses the association between metabolic syndrome and breast cancer (BC) outcomes in BC survivors.MethodsSystematic searches were carried out in PubMed and Embase using variations of the search terms: breast neoplasms (population), metabolic syndrome (exposure), and survival (outcome). Metabolic syndrome was characterized according to the American Heart Association, which includes the presence of three out of five abnormal findings among the risk factors: high blood pressure, high triglycerides, low high‐density lipoprotein, high fasting glucose, and central obesity. Data were obtained from observational studies and randomized controlled trials that utilized survival statistics and reported survival ratios to investigate how the presence of metabolic syndrome at the time of BC diagnosis is associated with BC outcomes. Study data were independently extracted by two authors, and effect sizes were pooled using random‐effects models.ResultsFrom the 1019 studies identified in the literature search, 17 were deemed eligible. These encompassed 42,135 BC survivors. The pooled estimates revealed that BC survivors who had metabolic syndrome at the time of their BC diagnosis experienced increased risk of recurrence (HR 1.69, 95% CI: 1.39–2.06), BC mortality (HR 1.83, 95% CI: 1.35–2.49), and shorter disease‐free survival (HR 1.57, 95% CI: 1.36–1.81) compared to BC survivors without metabolic syndrome.ConclusionsAmong BC survivors, metabolic syndrome was associated with inferior BC outcomes. This necessitates the creation of clinical guidelines that include metabolic screening for BC survivors. Further research should identify effective interventions to reduce the prevalence of metabolic syndrome among BC survivors to improve metabolic health and BC outcomes.
Navigating cultural crossroads: A thematic analysis of individuals' sacrifices in intercultural romantic relationships
Authors: Naeimi Hanieh , Impett Emily A. 
Published: January 2025

AbstractObjectiveThis study aims to explore the unique sacrifices intercultural couples make to reconcile their cultural differences.BackgroundPartners in intercultural romantic relationships may be challenged to make sacrifices related to their cultural differences, termed cultural sacrifices. These sacrifices can act as catalysts for cultural change in families and society, yet there is a gap in our understanding of the types of cultural sacrifices partners make.MethodWe conducted reflexive thematic analysis on two online samples of individuals in intercultural relationships who wrote about their cultural sacrifices (n = 592). We employed a bottom‐up data‐driven approach to our analysis.ResultsWe identified 10 themes, including nine distinct themes of cultural sacrifices—cultural practices and norms, food, gender roles, language, parenting, prejudice, religion, relocation and travel, and social orientation—and one theme of not making a cultural sacrifice. Most themes were divided into subthemes to provide more context for individuals' experiences.ConclusionIndividuals in intercultural relationships often reconcile their cultural differences by giving up aspects of their own culture or finding ways to adapt to their partner's culture. This study provides the first descriptive overview of the types of cultural sacrifices partners make in their relationships.ImplicationsThese findings provide a better understanding of intercultural relationships, contribute to a more inclusive study of relationships, and offer valuable considerations for future research.
Damage Threshold and Population Dynamic of Meloidogyne javanica on Tomato Plant
Authors: Bouchtaoui El Mehdi , Smouni Abdelaziz , Dababat Abdelfattah A. , Mokrini Fouad 
Published: January 2025

ABSTRACTThe root‐knot nematode Meloidogyne javanica is a significant pathogen that causes substantial yield losses in tomato plants. Moroccan farmers generally lack knowledge regarding the density of this pathogen, which can trigger visible and localised symptoms. Additionally, regional studies that establish damage thresholds for this issue are scarce. This study investigated the damage threshold of M. javanica on tomato plants using nine initial population densities (Pi) of second‐stage juveniles (J2s): 0, 0.5, 1, 2, 4, 8, 16, 32 and 64 J2s (g dry soil)−1. Aboveground growth (plant height and fresh and dry shoot weight) and belowground growth (root length and diameter) were assessed after 90 days. The plant growth parameters were significantly reduced at higher inoculum densities. The Seinhorst model fitting revealed the highest minimum relative yield (m) for shoot fresh weight (m = 0.761 ± 0.012) and the lowest for root diameter (m = 0.509 ± 0.026). The tolerance limit (T) varied, with the highest shoot dry weight (T = 1.657 ± 0.329 J2s (g soil)−1) and lowest root diameter (T = 0.095 ± 0.019 J2s (g soil)−1). The production of eggs by M. javanica increased significantly with increasing initial population density, rising from 211 ± 64 eggs (g roots)−1 at 0.5 J2s (g soil)−1 to 3735 ± 380 eggs (g roots)−1 at 64 J2s (g soil)−1, representing a 17.7‐fold increase. Tomato plants exhibited the maximum galling index at lower nematode densities. Symptoms began at densities as low as 0.095 J2 (g soil)−1, with severity increasing with nematode density. Given the severe damage caused at low densities, Moroccan farmers must adopt early detection and effective management strategies.
Absence of Viral Replication Is Associated With Improved Outcome in Anti‐HCV‐Positive Patients With Hepatocellular Carcinoma
Authors: Giannini Edoardo G. , Pasta Andrea , Plaz Torres Maria Corina , Pieri Giulia , Cabibbo Giuseppe , Sangiovanni Angelo , Piscaglia Fabio , Campani Claudia , Missale Gabriele , Vidili Gianpaolo , Ghittoni Giorgia , Pelizzaro Filippo , Foschi Francesco Giuseppe , Morisco Filomena , Santi Valentina , Svegliati‐Baroni Gianluca , Azzaroli Francesco , Saitta Carlo , Brunetto Maurizia Rossana , Sacco Rodolfo , Ponziani Francesca Romana , Boninsegna Sara , Nardone Gerardo , Martini Andrea , Mega Andrea , Sacerdoti David , Magalotti Donatella , Vitale Alessandro , Bucci Laura , Trevisani Franco ,   Italian Liver Cancer (ITA.LI.CA) group
Published: January 2025

ABSTRACTBackground and AimsPresence of active hepatitis C virus (HCV) infection may influence the outcome of patients treated for hepatocellular carcinoma (HCC), although this issue has never been adequately assessed in a large series of patients. The aim of this study was to evaluate whether the presence of active HCV affects the survival of patients treated for HCC.MethodsThis study assessed the outcome of 3123 anti‐HCV‐positive patients with HCC, subdivided according to the presence of active HCV infection or previous sustained virological response (SVR). Comparisons were also carried out after propensity score matching (PSM) considering demographic, clinical and oncological characteristics.ResultsThe median overall survival from HCC treatment was longer in patients with SVR than in those with active HCV infection both before (n = 2118: 61.0 months [95% confidence internal (CI): 56.5–65.5] vs. n = 1005: 51.0 months [95% CI: 43.4–58.6]; p = 0.003) and after PSM (n = 1285: 60.0 months [95% CI: 55.3–64.7] vs. n = 926: 54.0 months [95% CI: 46.7–61.3]; p = 0.030). Active HCV infection was associated with a greater risk of mortality (hazard ratio: 1.22–1.27, p = 0.001) independently of liver‐ and tumour‐related variables, and modality of HCC treatment. Death due to liver failure was more common in patients with active HCV infection (24.5% vs. 17.1%; p = 0.001), while non‐liver‐related causes of death were more common in patients with SVR (25.0% vs. 17.0%; p = 0.001).ConclusionsSVR is associated with a better outcome in patients undergoing HCC treatment, thus suggesting that these patients may benefit from antiviral therapy for HCV independently of cure of HCC.
Prevalence of Crown Resorption in Amelogenesis Imperfecta due to Junctional Epidermolysis Bullosa
Authors: Besa‐Witto Colomba , Ortega‐Pinto Ana , Véliz Sebastián , Cornejo Marco , Fuentes Ignacia , Palisson Francis , Krämer Susanne 
Published: January 2025

ABSTRACTIntroductionJunctional epidermolysis bullosa (JEB) is a rare genetic disease manifesting with skin and mucosal blistering. As part of the JEB, patients present with syndromic amelogenesis imperfecta (AI). Reports have described external crown resorption (ECR) in the teeth of patients with JEB, but its prevalence is unknown.ObjectiveTo determine the prevalence of ECR in patients with JEB.MethodsA longitudinal retrospective cohort study was performed at the Special Care Dentistry Clinic, University of Chile. Clinical records of patients with JEB between 2005 and 2024 were analysed. Prevalence of ECR per patient, per type of tooth and per tooth was calculated.ResultsOf the 20 patients examined, 90% presented ECR in at least one tooth, with an average of 4.8 primary and 6.8 permanent teeth affected. The most affected type of teeth were the incisors. 57.5% of primary incisors and 68% of permanent incisors had resorption. The most affected tooth was #82 in primary dentition (75%) and #32 in the permanent dentition (88.9%).ConclusionsThe prevalence of ECR in patients with AI due to JEB caused by variants in LAMB3 was 90%. Establishing clinical and radiographic dental protocols for the early detection of ECR is essential to prevent extensive tooth destruction.
The Asian philosophical concepts in Vladimir Nabokov's The Original of Laura
Authors: Wang Siqi 
Published: January 2025

AbstractThis article presents a cross‐textual analysis of the refracted presence of Asian philosophical concepts in Vladimir Nabokov's posthumous novel, The Original of Laura (2009). It argues that the novel subtly parodies Yukio Mishima's dramatic suicide and his aesthetic ideal juxtaposing death with beauty. Nabokov blends his characteristic playfulness and sarcasm into the ritual suicides of Philip Wild and Adam Lind, suggesting that suicide is an absurd method of seeking fulfillment while simultaneously deconstructing the grim implications of mortality. Symbolically, the “Chinese butterflies” on the fans—exchanged between Flora and Wild through buying and selling—reference the Taoist “butterfly dream,” highlighting the illusory nature of the characters' existence. This metaphor links the lives and deaths of the mirror characters in The Original of Laura and My Laura, thus creating a complex echo between the inner and outer texts. Additionally, Buddhist elements are integrated into the story, as seen in Wild's extraction of dictionary entries on Nirvana. Ironically, his experiments with self‐obliteration reveal a shallow understanding of the “extinction of the self,” which, essentially, requires an internal detachment from the self, thereby adding layers of mockery to his misguided path to transcendence.
The CmTGA1–CmRbohD Cascade Confers Resistance Against Chrysanthemum White Rust by Promoting Reactive Oxygen Species Generation
Authors: Chen Qi , Jin Ruibing , Liu Di , Wang Siqi , Chen Changge , Mao Hongyu 
Published: January 2025

ABSTRACTChrysanthemum white rust (CWR), caused by Puccinia horiana Heen., is a serious disease of chrysanthemum worldwide. This disease reduces the quality and yield of Chrysanthemum morifolium, leading to significant losses for chrysanthemum growers and industries. It is often referred to as the ‘cancer’ of chrysanthemum. The most effective approach to managing CWR is to utilise host resistance. Reactive oxygen species (ROS) are conserved basic defence compounds in higher plants that are generated in response to biotic stresses. This study reported the TGACG‐binding (TGA) transcription factor 1 (CmTGA1) in chrysanthemum. Subcellular localisation analysis revealed that CmTGA1 is localised in the nucleus and cytoplasm. Overexpression or knockout of CmTGA1 in chrysanthemum increased or reduced CWR resistance by regulating ROS generation, the activities of antioxidant enzymes, and CmRbohD (a gene mediating ROS generation) expression. Yeast one‐hybrid, dual‐luciferase, and electrophoretic mobility shift assays showed that CmTGA1 bound directly to the as‐1 element in the promoter region of CmRbohD. Subcellular localisation analysis revealed that CmRbohD was localised in the cytomembrane and cytoplasm. CmRbohD was induced by P. horiana infection and enhanced CWR resistance by promoting ROS generation, activating the antioxidant enzyme system, and catalysing lignin biosynthesis. Our results showed that CmTGA1 activated CmRbohD to improve the CWR resistance via the ROS pathway in chrysanthemum. Our findings provided novel insights into the regulatory pathways involving the CmTGA1‐CmRbohD cascade‐mediated regulation of CWR resistance, demonstrating an effective strategy to improve tolerance to P. horiana in chrysanthemum.
Perspectives on Conducting Behavioral Intervention With Adolescents Using a Virtual Platform—A Thematic Analysis From the Viewpoint of Study Coordinators
Authors: Ghezzo Adamo , Pascale Giuseppe , Dew Mary Amanda , Rennick Janet E. , Dabbs Annette DeVito , Dharnidharka Vikas R. , Knäuper Bärbel , Mayersohn Gillian , Teoh Chia Wei , Phan Véronique , Blydt‐Hansen Tom , Smith Jodi , Foster Bethany J. 
Published: January 2025

ABSTRACTBackgroundThe COVID‐19 pandemic led to widespread adoption of virtual communication platforms. Virtual study visits were implemented in the pilot cluster randomized trial (CRT) stage of Teen Adherence in KidnEy transplant Improving Tracking To Optimize Outcomes (TAKE‐IT TOO). The present study aimed to understand study coordinators' perspectives on conducting a behavioral intervention with adolescent kidney transplant recipients using virtual conferencing platforms.MethodsStudy coordinator participants (N = 6) completed questionnaires and participated in a semi‐structured interview that probed comfort with digital technology, issues encountered, and overall perspectives on conducting virtual study visits. Qualitative thematic analysis was used to identify themes and subthemes.ResultsParticipants expressed confidence with technology and ability to handle the complexities of the virtual conferencing. Some expressed that virtual study visits led to a change in work habits and higher workload due to increased technology complexity. Qualitative analyses of participant interviews revealed four themes: adaptability, accessibility, logistics (including subthemes scheduling and fluidity), and communication (including subthemes clarity, engagement, and rapport). Convenience for coordinators and the perceived comfort for adolescents were noted advantages for virtual visits. Technical issues, periodic adolescent distractions, and challenges with instructional teaching through virtual conferencing were identified as potential limitations of virtual study visits.ConclusionsOverall, virtual study visits were appreciated and endorsed by study coordinators. Researchers should consider the feasibility of completing study‐related tasks virtually, including accessibility of visual materials on all type of electronic devices, and ensure adequate training of study personnel when deciding to implement virtual platform in CRTs.
Association Between Early Immunosuppression Center Variability and One‐Year Outcomes After Pediatric Liver Transplant
Authors: Raghu Vikram K. , Rothenberger Scott D. , Squires James E. , Eisenberg Elizabeth , Peters Anna L. , Halma Jennifer , Antala Swati , Batsis Irini D. , Zhang Ke‐You , Feldman Amy G. , Leung Daniel H. , Lobritto Steven J. , Bucuvalas John , Horslen Simon P. , Mazariegos George V. , Perito Emily R. 
Published: January 2025

ABSTRACTBackgroundDespite the existence of institutional protocols, liver transplant centers often have variability in early immunosuppression practices. We aimed to measure within‐center variability in early immunosuppression after pediatric liver transplant (LT) and examine its association with one‐year outcomes.MethodsWe analyzed pediatric LTs from 2013 to 2018 in the United Network for Organ Sharing registry, with data aggregated by center. We categorized induction regimen as corticosteroids only vs. T‐cell depleting antibody vs. non‐T‐cell depleting antibody. Primary exposures were coefficient of immunosuppression variability (CIV) in (1) induction and (2) mycophenolate mofetil (MMF) use. Primary outcomes were one‐year graft survival, patient survival, and acute rejection rate within the first year after transplant.ResultsThe study cohort included 2542 LT recipients from 67 LT centers. Sixteen centers (24%) had no MMF variability; twenty‐five centers (37%) had no induction variability. In multivariable analysis, induction CIV was associated with 2.72 times greater odds of acute rejection in the first year (OR 2.72; 95% CI 1.66–4.45; p < 0.001). MMF CIV was not associated with rejection (OR 1.22, 95% CI 0.66–2.25, p = 0.527). Neither one‐year graft nor patient survival were associated with induction or MMF CIV.ConclusionsInduction CIV is associated with higher one‐year acute rejection odds and did not impact short‐term graft or patient survival. Improved understanding of the reasons for high CIV will inform future work aiming to determine whether reducing variability may improve outcomes.
Access to Kidney Transplantation for Minority Children With End‐Stage Renal Disease and Predictors of Post‐Transplant Outcome: Impact of Race and Ethnicity
Authors: Matloff Robyn , Foster Caitlin E. , Hanna Jonathan , Mason Sherene , Morgan Glyn , Serrano Oscar K. 
Published: January 2025

ABSTRACTBackgroundRacial disparities in access to kidney transplantation (KT) have been described among children with end‐stage renal disease in the United States. It has been suggested that these disparities stem from a combination of clinical and socioeconomic factors.MethodsWe evaluated data from the US Scientific Registry of Transplant Recipients (SRTR) of all pediatric (< 18 years old) KT recipients from 1999 to 2014 and compared outcomes by race or ethnicity: Hispanic, non‐Hispanic Whites (NHW), and non‐Hispanic Blacks (NHB). We assessed 1‐ and 5‐year patient survival (PS) and death‐censored graft survival (DCGS) using Kaplan–Meier survival cures. Multivariate logistic regressions of graft failure by 1 and 5 years examined effects of race/ethnicity by controlling for donor and recipient characteristics including living or deceased donor, recipient age, BMI, re‐transplant status, cPRA, HLA mismatch, graft rejection, cold ischemia time (CIT), and type of insurance.ResultsDuring the 15‐year period, 11 740 (6596 NHW, 2306 NHB, and 2838 Hispanic) pediatric KT recipients were performed in the United States. Compared to NHW (250 ± 335 days), NHB (293 ± 348; p < 0.001) and Hispanics (322 ± 353; p < 0.001) spent more time on the waitlist. One‐year PS for NHW, NHB, and Hispanics was 98.6%, 98.6%, and 99.0%, respectively; one‐year DCGS was 95.5%, 93.7%, and 96.0%, respectively. Five‐year PS for NHW, NHB, and Hispanics was 95.5%, 93.1%, and 95.5%, respectively; five‐year DCGS was 80.7%, 60.3%, and 76.3%, respectively. Multivariate analysis showed that higher recipient cPRA (OR 1.0, 95% CI 1.0–1.0; p = 0.005), greater HLA mismatch (OR 1.1, 95% 1.0–1.3; p = 0.008), rejection (OR 3.9, 95% CI 2.1–7.0; p < 0.001), and secondary kidney transplantation (OR 15.0, 95% CI 11.5–19.4; p < 0.001) were associated with 1‐year graft loss; older recipient age (OR 1.1, 95% CI 1.1–1.1; p < 0.001), higher recipient cPRA (OR 1.0, 95% CI 1.0–1.0; p < 0.001), greater HLA mismatch (OR 1.1, 95% CI 1.0–1.1; p = 0.002), rejection (OR 2.0; 95% CI 1.3–3.0; p = 0.001), and secondary kidney transplantation (OR 11.2, 95% CI 9.6–13.0; p < 0.001) were predictive of 5‐year graft loss. Patients with public insurance have higher risks of 1‐year and 5‐year graft loss (p < 0.001) than those with private insurance payers.ConclusionRacial and ethnic minority children in the United States have lower access to KT with clinical outcomes suggesting a disparate trajectory. NHB demonstrate unfavorable DCGS while Hispanic children have comparable or better DCGS and PS outcomes compared to NHW. Elucidating the clinical or socioeconomic roots of these differences may identify mitigating measures that can improve KT outcomes for these minoritized populations.
Consecutive oxidative stress in CATALASE2‐deficient Arabidopsis negatively regulates Glycolate Oxidase1 activity through S‐nitrosylation
Authors: Yang Tianzhao , Mu Xiujie , Yu Mei , Ergashev Ulugbek , Zhu Yihan , Shi Ningning , Li Ninghong , Luo Long , Zhang Kuanchao , Han Yi 
Published: January 2025

AbstractGlycolate oxidase (GOX) is a crucial enzyme of photorespiration involving carbon metabolism and stress responses. It is poorly understood, however, how its activities are modulated in response to oxidative stress elicited by various environmental cues. Analysis of Arabidopsis catalase‐defective mutant cat2 revealed that the GOX activities were gradually repressed during the growth, which were accompanied by decreased salicylic acid (SA)‐dependent cell death, suggesting photorespiratory H2O2 may entrain negative feedback regulation of GOX in an age‐dependent manner. Intriguingly, a loss‐of‐function mutation in GLYCOLATE OXIDASE1 (GOX1) rather than in GOX2 and GOX3 attenuated the SA responses of cat2. We found that GOX1 is S‐nitrosylated at Cys‐343 during consecutive oxidative stress in the cat2 mutant. Subsequently, increased GOX1‐SNO formations may contribute to progressively decreased GOX activities and then compromised photorespiratory H2O2 flux, which forms a negative feedback loop limiting the amplified activation of SA‐dependent defence responses. Together, the data reveal that GOX S‐nitrosylation is involved in the crosstalk between photorespiratory H2O2 and NO signalling in the fine‐tuning regulation of oxidative stress responses and further highlight that NO‐based S‐nitrosylation acts as an on–off switch for ROS homeostasis.