bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rupture of the staple suture site after stapling the right inferior pulmonary vein with double rows of staples: a case report
Authors: Suzuki Jun , Shiono Satoshi , Watanabe Hikaru , Sasage Takayuki , Hoshijima Kazumasa , Abe Kohei , Uchida Tetsuro 
Published: January 2025

Abstract
Background
With advancements in minimally invasive thoracic surgery techniques, such as video-assisted thoracoscopic surgery and robotic surgery, the design of vascular staplers has evolved to meet the requirements of these procedures. Consequently, newer generations of automatic staplers with improved handling and reduced size have been introduced, such as two-row staplers, which are more maneuverable and less bulky than their three-row counterparts.

Case presentation
A 68-year-old man with lung cancer underwent a right middle and lower lobectomy due to tumor invasion into the central middle bronchial trunk, rendering the preservation of the middle lobe impossible. His medical history included chronic atrial fibrillation. The surgery involved a posterolateral incision and a fifth intercostal thoracotomy, where various pulmonary arteries and veins were dissected using vascular staples. Despite completing the surgery without initial complications, the patient experienced significant postoperative bleeding, leading to approximately 800 mL of bloody fluid being drained after coughing episodes. Reoperation was necessary to address and control the bleeding, which was challenging due to the location and nature of the hemorrhage. The source was identified at the transected edge of the inferior pulmonary vein, requiring direct suture after pericardium incision for better access. The total operative time amounted to 751 min, with a blood loss of 2092 mL. The patient recovered smoothly from the second operation and was discharged on the fifth postoperative day. Histopathological examination revealed myocardial cell presence adjacent to the pulmonary vein wall, suggesting that vein thickening could have played a role in the observed postoperative bleeding.

Conclusions
In conclusion, when selecting staples for vascular use, particularly for the detachment of pulmonary veins, it is advisable to carefully choose between two-row and three-row staples.
α-catenin phosphorylation is elevated during mitosis to resist apical rounding and epithelial barrier leak
Authors: Le Phuong M. , Quinn Jeanne M. , Flozak Annette S. , Steffeck Adam W. T. , Huang Che-Fan , Gottardi Cara J. 
Published: January 2025

ABSTRACT
Epithelial cell cohesion and barrier function critically depend on α-catenin, an actin-binding protein and essential constituent of cadherin-catenin-based adherens junctions. α-catenin undergoes actomyosin force-dependent unfolding of both actin-binding and middle domains to strongly engage actin filaments and its various effectors; this mechanosensitivity is critical for adherens junction function. We previously showed that α-catenin is highly phosphorylated in an unstructured region that links the mechanosensitive middle and actin-binding domains (known as the P-linker region), but the cellular processes that promote α-catenin phosphorylation have remained elusive. Here, we leverage a previously published phospho-proteomic data set to show that the α-catenin P-linker region is maximally phosphorylated during mitosis. By reconstituting α-catenin CRISPR knockout MDCK cells with wild-type, phospho-mutant and phospho-mimic forms of α-catenin, we show that full phosphorylation restrains mitotic cell rounding in the apical direction, strengthening the interactions between dividing and non-dividing neighbors to limit epithelial barrier leak. As the major scaffold components of adherens junctions, tight junctions and desmosomes are also differentially phosphorylated during mitosis, we reason that epithelial cell division may be a tractable system to understand how junction complexes are coordinately regulated to sustain barrier function under tension-generating morphogenetic processes.
A review of the empirical evidence for costs of plasticity in ectothermic animals
Authors: Little Alexander G. , Seebacher Frank 
Published: January 2025

ABSTRACT
Phenotypic plasticity can represent a vital adaptive response to environmental stressors, including those associated with climate change. Despite its evolutionary advantages, the expression of plasticity varies significantly within and among species, and is likely to be influenced by local environmental conditions. This variability in plasticity has important implications for evolutionary biology and conservation physiology. Theoretical models suggest that plasticity might incur intrinsic fitness costs, although the empirical evidence is inconsistent and there is ambiguity in the term ‘cost of plasticity’. Here, we systematically review the literature to investigate the prevalence of costs associated with phenotypic plasticity in ectothermic animals. We categorized studies into those assessing ‘costs of phenotype’ (trade-offs between different plastic trait values) and ‘costs of plasticity’ (intrinsic costs of the capacity for plasticity). Importantly, the experimental designs required to detect costs of plasticity are inherently more complex and onerous than those required to detect costs of phenotype. Accordingly, our findings reveal a significant focus on costs of phenotype over costs of plasticity, with the former more frequently detecting costs. Contrary to theoretical expectations, our analysis suggests that costs of plasticity are neither universal nor widespread. This raises questions about the evolutionary dynamics of plasticity, particularly in stable environments. Our analysis underscores the need for precise terminology and methodology in researching costs of plasticity, to avoid conflating costs associated with plastic traits with costs more intrinsic to plasticity. Understanding these nuances is crucial for predicting how species might adapt to rapidly changing environments.
Screening for Relative Energy Deficiency in Sport: Detection of Clinical Indicators in Female Endurance Athletes
Authors: Wasserfurth Paulina , Halioua Robin , Toepffer Désirée , Lautz Zoë , Engel Helena , Melin Anna Katarina , Torstveit Monica Klungland , Claussen Malte Christian , Koehler Karsten 
Published: January 2025

ABSTRACT

Purpose
The purpose was to evaluate the individual and combined use of the Low Energy Availability in Females Questionnaire (LEAF-Q) and the Brief Eating Disorder in Athletes Questionnaire (BEDA-Q) to detect clinical indicators associated with Relative Energy Deficiency in Sport (REDs).

Methods
In this cross-sectional study, 50 female endurance athletes training ≥4x/week completed the LEAF-Q and BEDA-Q and were assessed for presence of selected REDs indicators. Athletes meeting the criteria for mild or more severe REDs severity/risk according to the International Olympic Committee REDs Clinical Assessment Tool Version 2 (IOC REDs CAT2) were classified as REDs cases. Diagnostic properties of the German versions of the LEAF-Q and BEDA-Q were assessed at different cut-offs using receiver operating characteristics calculations.

Results
Fourteen (28%) athletes were classified as REDs cases. The LEAF-Q had a sensitivity of 79% and a specificity of 50%, with a positive predictive value (PPV) of 38% and negative predictive value (NPV) of 86%. For detection of disordered eating behaviour/eating disorder (DE/ED), the BEDA-Q showed a sensitivity and specificity of 71% and 76%, respectively, with a PPV of 68% and NPV of 79%. Out of 14 REDs cases, nine (64%) scored positive in the LEAF-Q and BEDA-Q. Two athletes (14%) scored positive only in the LEAF-Q and one athlete scored positive only in the BEDA-Q. Two REDs cases remained undetected by both questionnaires.

Conclusions
Among German female endurance athletes, the LEAF-Q and BEDA-Q are good screening tools to detect REDs cases with mild or more severe severity/risk as classified according to the IOC REDs CAT2. Further clinical assessments should be initiated when athletes score positive in at least one of the questionnaires.
Associations Between Walking Pace, APOE-ε4 Genotype, and Brain Health in Middle-Aged to Older Adults
Authors: Aslan Daniel H. , Sayre M. Katherine , Bharadwaj Pradyumna K. , Ally Madeline , Maltagliati Silvio , Lai Mark H.C. , Wilcox Rand R. , Klimentidis Yann C. , Alexander Gene E. , Raichlen David A. 
Published: January 2025

ABSTRACT
Poor physical function and possession of the e4 allele of the apolipoprotein E (APOE) gene are each associated with increased dementia risk, but it is unclear how these exposures interact to influence brain health. Purpose: To investigate whether self-reported walking pace (a marker of physical function) and the presence of APOE-ε4 allele interact to modify brain health outcomes. Methods: We used data from a prospective cohort study of middle-aged to older adults from the UK Biobank who self-reported walking pace (slow or steady-to-brisk), and who were initially free of dementia (n = 415,110). Incident all-cause dementia was obtained from hospital and death registry records, and structural brain volumes (right and left hippocampus volumes, total gray matter volume, and volume of white matter hyperintensities) were measured from a subset of participants (n = 33,113). Cox proportional hazard models and generalized linear models were used to assess associations between exposures and outcomes. Results: Slow walking pace and the presence of APOE-ε4 allele were associated with increased dementia risk [HR = 1.79 (1.66,1.93), p < 0.001; HR = 3.06 (2.90,3.23), p < 0.001, respectively], and there was an interaction between these associations, indicating that the association of walking pace with dementia risk is modified by APOE-ε4 status [(reference group: HRSteady-Brisk/APOE-ε4- = 1); HRSlow/APOE-ε4- = 2.03(1.84,2.25), p < 0.001; HRSteady-Brisk/APOE-ε4+ = 3.21(3.02,3.41), p < 0.001; HRSlow/APOE-ε4+ = 4.99 (4.48,5.58), p < 0.001]. Slow self-reported walking pace was associated with worse brain volume outcomes and these associations were not modified by APOE-ε4 genotype. Conclusions: These results suggest walking pace and APOE-ε4 status independently influence brain volume outcomes, but both factors independently and jointly contribute to increased dementia risk. Individuals with both risk factors (slow walking pace and APOE-ε4 allele) show the strongest associations with dementia risk.
Clinical control in COPD and therapeutic implications: The EPOCONSUL audit
Authors: Calle Rubio Myriam , Miravitlles Marc , Soler Cataluña Juan José , López-Campos José Luis , Alcázar Navarrete Bernardino , Fuentes Ferrer Manuel E. , Rodríguez Hermosa Juan Luis 
Published: January 2025

Objective
This study aimed to evaluate clinical control in chronic obstructive pulmonary disease (COPD), the consequences in terms of treatment decisions, and their potentially associated factors during follow-up of patients in real-life clinical practice.

Methods
EPOCONSUL 2021 is a cross-sectional audit that evaluated the outpatient care provided to patients with a diagnosis of COPD in respiratory clinics in Spain and multivariable logistic regression models to assess the relationships between clinical control and clinical inertia.

Results
4225 patients from 45 hospitals in Spain were audited. Clinical control was analyzed in 1804 (42.7%) patients who met all the Spanish COPD Guidelines (GesEPOC) criteria. 49.1% of patients were classified as uncontrolled, and 42.2% of patients disagreed with the level of control determined by their doctor, which was reported as good during the visit. There was therapeutic inertia (TI), in other words not making any change or taking any action in the treatment of COPD, in 68.4% of uncontrolled patients and no action was taken during the visit for 9.1% of uncontrolled patients. Factors associated with TI in uncontrolled patients were disagreement with the degree of control reported by the doctor who performed the examination ☯physician classifies and reports disease as controlled versus uncontrolled, OR: 3.37 (2.33–4.88), p<0.001] and having a lower burden of associated comorbidities ☯Charlson comorbidity index ≥3 versus <3, OR 0.8 (0.1–3.0), p = 0.014]. The probability of disagreeing with the physician’s classification of the degree of COPD control in uncontrolled patients was lower in patients with severe exacerbations ☯OR 0.3 (0.17–0.78), p = 0.009] and those with more exacerbations in the last year ☯OR 0.6 (0.4–0.9), p = 0.019].

Conclusions
Therapeutic inertia exists in more than half of uncontrolled patients and is more likely when there is disagreement with the assessment of the physician responsible for the visit, who reported there being good disease control, a situation that was more likely in patients with less history of exacerbations.
تأثير جودة التقارير المالية في ترشيد قرارات الإستثمارية
Authors: Mohammed Kasar A. , Salman Shaayma A. , Ahmad Kawa I. 
Published: January 2025

يهدف البحث الى التعرف على تأثير جودة التقارير المالية في ترشيد القرارات الإستثمارية. من اجل الوصول الى ذلك تم استخدام المنهج الوصفي التحليلي من خلال تصميم استمارة استبيان وتوزيعها على عينة عشوائية لعدد من (المحاسبين القانونيين في المكاتب الخاصة،روؤساء مجالس الإدارات في المصارف التجارية في ،محاسبين ومدققين التابعين لتلك المصارف وكذلك روؤساء أقسام المحاسبة في الجامعات الحكومية والأهلية) في المؤسسات المالية وغير المالية في محافظة دهوك. وبعد اجراء التحليل الاحصائي توصل الباحثين الى مجموعة من الاستنتاجات من أهمها ان جودة التقارير المالية من خلال خصائصها الرئيسية (الملائمة والموئوقية،القابلية للمقارنة) لها تأثير على قرارات الإستثمارية بنسبة مايقارب نصفها أما الباقي فقد يرجع الى اسباب أخرى لم يتم التطرق اليها في البحث وايضا تبين ان هناك تباين في تأثير هذه الخصائص على ترشيد القرارات الاستثمارية ،وقد طرح الباحثين مجموعة من المقترحات اهمها من الضروري الإهتمام بطرق اعداد التقارير المالية وتطبيق خصائص الجودة فيها بحيث تكون اكثر دقة وكفاءة تتصف بالملائمة والموثوقية وقابلية للمقارنة، وذلك بنشر الوعي لدى افراد العاملين في المؤسسات المالية وغير المالية من خلال فتح دورات تدريبية وتعيين كوادر وظيفية الذين يمتلكون خبرة عالية في هذا المجال.، وفي النهاية قدم البحث بعض العناوين التي من شأنها ان تصلح لتكون نقطة بداية لدراسات مستقبلية في نفس المجال.
Категория доверия к массмедиа в условиях информационной турбулентности: время обновлять концепции?
Authors: Вырковский Андрей Владимирович , Шамсутдинова Юлия Фаритовна 
Published: January 2025

Статья носит постановочный, проблемно-ориентированный характер: она посвящена определению характеристик новой феноменологии доверия к медиа. Авторы предполагают, что информационно-коммуникационный контекст, сложившийся в настоящее время в России и в мире, может стать причиной потенциальных изменений в феноменологии доверия к медиа.
Новизна предлагаемого подхода заключается в попытке понять, каким образом представители российской аудитории в текущей ситуации принимают решения о доверии тем или иным медиа, а также в попытке концептуализировать сомнение как категорию, которая может играть большую роль в процессе формирования критического отношения к текстам, авторам и брендам.
В результате исследования, которое было проведено в период с декабря 2022 г. по июнь 2023 г. с использованием метода полуструктурированного интервью, стало понятно, что «классические» факторы, используемые исследователями для определения уровня доверия к медиа, отходят на второй план: аудитория может потреблять контент медиа, изначально сомневаясь в его достоверности. Помимо феномена априорного сомнения авторы также выявляют и описывают в статье феномен «скептического медиапотребления». В практическом отношении результаты исследования могут быть приняты во внимание авторами контента и медиакомпаниями, для которых важен уровень доверия аудитории.
To Begin so Early and to Persevere over a Long Period of Time.​ Reflections on Time on the Horizon of Human Experience in the Anonymus Iamblichi
Authors: Diniz Peixoto Miriam Campolina 
Published: January 2025

The interest of scholars in the Anonymous of Iamblichus has been oriented in two main ways: it focuses either on the problem of its dating and authorship, or on one or other of the many themes which seem to have been on the agenda of the investigation of its author. My interest is in this second way and I propose to examine the author’s conception of time on the horizon of human nature. What makes man truly man (ἀνὴρ ἀληθῶς ἀγαθός – DK 89, 4)? I intend to point the importance of the notion of time in the context of the human experience for who aspires to be an agathos, an enkratestaton. First, I will examine the lexical and semantic field of time employed to characterize the human condition and justify the prerogatives of author regarding human behaviour and action. Second, I will discuss the different aspects and contexts considered by the author to develop his argument. Among these aspects we have: (i) the distinction between what is innate in us (φῦναι), and what must be acquired through effort (φιλοπονία) and perseverance over time (πολὺν χρόνον); (ii) the opinion that anyone who wants to guide theirlife in view of what is beautiful and good (καλόν καὶ ἀγαθόν) must to be initiated very early (πρωιαίτατα), or should start “immediately and increasing to the end” (αὐτίκα τε ἀρξάμενον καὶ συναυξηθὲν είς τέλος); (iii) the need for him to use his own resources “always and not occasionally” (DK 89, 1–2). We will examine in our paper the passages in which a concept of time appears, in order to show that this is one of the centrepieces of the author’s argument and the way par excellence to understand the underlying concept of human nature at the thought of its author.
Aristotle’s Zeno. How the History of Philosophy is Intertwined with Contemporary Philosophy
Authors: Fano Vincenzo 
Published: January 2025

Hermeneutical scholars doubt whether many past authors really existed. They are only a sort of construction built with the passing of time. Indeed, Zeno of Elea, for instance, was real, and historians attempted to establish what he wrote and intended to say. Our most important source for Zeno is Aristotle. Zeno’s paradoxes deeply influenced the latter’s Physics. Is Aristotle’s physics relevant to us? Yes, because philosophical problems are too complex not to be considered in their historical development as well. In reading Zeno and Aristotle, we can see physical problems from a completely different perspective and learn a lot. In other terms, the historical Zeno is disorienting for us. On the other hand, Zeno’s historical legacy is extremely interesting for us. Indeed, we will see how Zeno’s and Aristotle’s reflections on continuum, extension, and movement could contribute to a better understanding of these notions in the contemporary debate.
Thoracic load carriage impairs the acute physiological response to hypoxia in healthy males
Authors: Baur Daniel A. , Lassalle Caroline M. , Kurti Stephanie P. 
Published: January 2025

AbstractTo assess the impact of thoracic load carriage on the physiological response to exercise in hypoxia. Healthy males (n = 12) completed 3 trials consisting of 45 min walking in the following conditions: (1) unloaded normoxia (UN; FIO2:20.93%); (2) unloaded hypoxia (UH; FIO2:~13.0%); and (3) loaded hypoxia (LH; 29.5 kg; FIO2:~13.0%). Intensity was matched for absolute VO2 (2.0 ± 0.2 L·min−1) across conditions and relative VO2 (64.0 ± 2.6 %VO2max) across hypoxic conditions. With LH versus UH, there were increases in breathing frequency (5–11 breaths·min−1; p < 0.05) and decreases in tidal volume (10%–18%; p < 0.05) throughout exercise due to reductions in end inspiratory lung volumes (p < 0.05). Consequently, deadspace (11%–23%; p < 0.05) and minute ventilation (7%–11%; p < 0.05) were increased starting at 20 and 30 min, respectively. In addition, LH increased perceived exertion/dyspnea and induced inspiratory (~12%; p < 0.05 vs. UN) and expiratory (~10%; p < 0.05 vs. pre‐exercise) respiratory muscle fatigue. Expiratory flow limitation was present in 50% of subjects during LH. Cardiac output and muscle oxygenation were maintained during LH despite reduced stroke volume (6%–8%; p < 0.05). Finally, cerebral oxygenated/total hemoglobin were elevated in the LH condition versus UH starting at 15 min (p < 0.05). Thoracic load carriage increases physiological strain and interferes with the compensatory response to hypoxic exposure.
Electrospun polyacrylonitrile/regenerated cellulose/citral nanofibers as active food packagings
Authors: Wenjin Cheng , Wangkai Cheng , Lulu Zhang , Nannan Li 
Published: January 2025

Abstract
The production of food packaging membranes with antibacterial activity is of great significance because it can inactivate bacteria in food and protect the human body from food-borne diseases. Herein, a novel polyacrylonitrile (PAN)/cellulose acetate (CA) composite nanofibers membrane with citral as an antibacterial agent was fabricated by utilizing electrospinning technology. Subsequently, the PAN/regenerated cellulose (RC)/citral composite nanofibers membrane was obtained through an alkaline hydrolysis process and citral grafting modification strategy. At the same time, the preservation efficacy of this membrane in refrigerated chicken breast was investigated. Results indicate that the PAN/RC/citral composite nanofibers membrane, modified by grafting citral, exhibits uniform fiber diameter, favorable morphology, and excellent mechanical properties. Moreover, citral crosslinks with RC components in fiber membranes significantly reduce the total bacterial count and total volatile basic nitrogen value in chicken breast during the packaging and storage process, thereby extending the shelf life of refrigerated chicken breast. This research provides a new approach to the production of antibacterial food packaging films and demonstrates their broad potential application value in the field of food packaging.
Evaluation of the analytical performance of the Beckman Coulter Unicel DXI 800 Access Total 25(OH) Vitamin D immunoassay
Authors: Topçuoğlu Canan , Sezer Sevilay , Yılmaz Fatma Meriç , Kösem Arzu , Ercan Mujgan , Turhan Turan 
Published: January 2025

Abstract

Background
As vitamin D has recently been implicated in various diseases, vitamin D testing has gained a lot more significance. Vitamin D deficiency is quite prevalent, and detection of this condition is important. Several manufacturers have developed new automated immunoassays for this purpose. In this study, we aimed to evaluate the analytical performance of the Access Total 25(OH) Vitamin D immunoassay on the Beckman Coulter Unicel DXI 800 analyzer, through comparison with the reference method, liquid chromatography/tandem mass spectrometry (LC-MS/MS).

Methods
The study was conducted with 148 patient samples which were sent to Ankara Numune Training and Research Hospital for routine vitamin D testing. Every sample was analyzed with both Unicel DXI 800 immunoassay analyzer and LC-MS/MS. The concordance of the results was evaluated with Passing-Bablok regression analysis and Bland-Altman plot. Additionally, imprecision, interference, limit of blank (LOB), recovery, linearity and carry-over studies were performed for the Beckman Coulter Unicel DXI 800 analyzer.

Results
When compared to LC-MS/MS, the Access Total 25(OH) Vitamin D immunoassay on the Beckman Coulter Unicel DXI 800 analyzer had an R-value of 0.957 (intercept: −3.938, slope: 1.185) and a mean bias of 9.5%. The concordance correlation coefficient (CCC) between the two methods was 0.916. The intra-assay, inter-assay and total coefficient of variation (CV%) for the Unicel DXI 800 vitamin D immunoassay were 3.3%, 5.3% and 8.3%, respectively, at 31.7 ng/mL concentration, and 2.1%, 3.2% and 7%, respectively, at 66.8 ng/mL concentration.

Conclusions
The Access Total 25(OH) Vitamin D immunoassay method has acceptable analytical performance, and the results are in concordance with the LC-MS/MS results.