bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrogenesis and tectonic significance of the Early Cretaceous Xizhelimu diorite in Keyouzhongqi, Inner Mongolia, China
Authors: Tian Li , Sun Deyou , Gou Jun , He Zhonghua , Zhang Duo 
Published: May 2023

To determine the emplacement age, petrogenesis, and geodynamic setting of the Xizhelimu diorite in Keyouzhongqi, Inner Mongolia of northeastern China, a detailed study of the petrography, geochronology, and whole-rock geochemistry has been conducted. Geological and petrographic studies show that the Xizhelimu diorite is zoned: the central lithofacies zone is composed of medium-fine-grained monzodiorite and quartz diorite, and the marginal lithofacies zone is fine-grained diorite. The zircon U–Pb dating results show that the ages of the central and marginal facies are 133.5 ± 1.9 and 133.4 ± 1.4 Ma, respectively. The whole-rock rare earth and trace element characteristics of the Xizhelimu diorite show an O-type adakite affinity. Combining the analysis of zircon Hf isotope composition ( εHf(t) values of +7.7 to +10.0), the geochemical features of whole rock, and the results of partial melting modeling, we suggest that the parental magma of the Xizhelimu diorite was derived from the partial melting of altered oceanic crust mixing with subducting sediments at shallow depths. In the early stage of early Cretaceous, the Xizhelimu diorite originated in an extensional setting, mainly related to the closure of the western part of the Mongol–Okhotsk Ocean. The upwelling asthenospheric flow in this extensional setting induced partial melting of the paleo-oceanic crust to form the parental magma of the Xizhelimu diorite.
A vacuum solution of modified Einstein equations based on fractional calculus
Authors: Di Teodoro A. , Contreras E. 
Published: May 2023

AbstractIn this work, we construct a modified version of the Einstein field equations for a vacuum and spherically symmetric spacetime in terms of the Riemann–Liouville fractional derivative. The main difference between our approach and other works is that we ensure that both the classical differential equations and the classical solutions are exactly recovered in the limit when the fractional parameter is turned off. We assume that the fractional equations are valid inside and near the horizon radius and match the classical solution at the horizon. Our approach resembles the Herrera–Witten strategy (Adv High Energy Phys 2018:3839103, 2018, https://doi.org/10.1155/2018/3839103, arXiv:1806.07143 [gr-qc]), where the authors constructed an alternative black hole solution by assuming that inside the horizon the spacetime is hyperbolically symmetric and matches the classical spherically symmetric exterior solution at one point at the horizon. We obtain that, depending on the value of the fractional parameter, the solutions can be interpreted as a regular black hole or a gravastar. As a final step, we compute the fractional curvature scalars and show that the solution is regular everywhere inside the horizon.
Integrable hydrodynamics of Toda chain: case of small systems
Authors: Kundu Aritra 
Published: May 2023

AbstractPassing from a microscopic discrete lattice system with many degrees of freedom to a mesoscopic continuum system described by a few coarse-grained equations is challenging. The common folklore is to take the thermodynamic limit so that the physics of the discrete lattice describes the continuum results. The analytical procedure to do so relies on defining a small length scale (typically the lattice spacing) to coarse grain the microscopic evolution equations. Moving from the microscopic scale to the mesoscopic scale then requires careful approximations. In this work, we numerically test the coarsening in a Toda chain, which is an interacting integrable system, i.e., a system with a macroscopic number of conserved charges. Specifically, we study the spreading of fluctuations by computing the spatio-temporal thermal correlations with three different methods: (a) using microscopic molecular dynamics simulation with a large number of particles; (b) solving the generalized hydrodynamics equation; (c) solving the linear Euler scale equations for each conserved quantities. Surprisingly, the results for the small systems (c) match the thermodynamic results in (a) and (b) for macroscopic systems. This reiterates the importance and validity of integrable hydrodynamics in describing experiments in the laboratory, where we typically have microscopic systems.
Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)
Authors: De Sutter Luna , Wozniak Agnieszka , Verreet Jasper , Vanleeuw Ulla , De Cock Lore , Linde Nina , Drechsler Christine , Esdar Christina , Sciot Raf , Schöffski Patrick 
Published: May 2023

Abstract

Purpose:
The majority of gastrointestinal stromal tumors (GIST) are driven by constitutively activated KIT/PDGFRA kinases and are susceptible to treatment with tyrosine kinase inhibitors. During treatment, most of these tumors will develop secondary mutations in KIT or PDGFRA inducing drug resistance, so there is an unmet need for novel therapies. We tested the efficacy of IDRX-42, a novel selective KIT inhibitor with high activity toward the most relevant KIT mutations, in 4 GIST xenograft models.

Experimental Design:
NMRI nu/nu mice were transplanted with patient-derived GIST xenograft models UZLX-GIST9 (KIT:p.P577del;W557LfsX5;D820G), UZLX-GIST2B (KIT:p.A502_Y503dup), UZLX-GIST25 (KIT:p.K642E), and the cell line–derived model GIST882 (KIT:p.K642E). Mice were treated daily with vehicle (control), imatinib (100 mg/kg), sunitinib (20 mg/kg), avapritinib (5 mg/kg), or IDRX-42 (10 mg/kg, 25 mg/kg). Efficacy was assessed by tumor volume evolution, histopathology, grading of histologic response, and IHC. The Kruskal–Wallis and Wilcoxon matched-pairs tests were used for statistical analysis, with P &lt; 0.05 considered as significant.

Results:
IDRX-42 (25 mg/kg) caused tumor volume shrinkage in UZLX-GIST25, GIST882, and UZLX-GIST2B, with a relative decrease to 45.6%, 57.3%, and 35.1% on the last day as compared with baseline, and tumor growth delay (160.9%) compared with control in UZLX-GIST9. Compared with controls, IDRX-42 (25 mg/kg) induced a significant decrease in mitosis. In UZLX-GIST25 and GIST882 grade 2–4 histologic response with myxoid degeneration was observed in all IDRX-42 (25 mg/kg)-treated tumors.

Conclusions:
IDRX-42 showed significant antitumor activity in patient- and cell line–derived GIST xenograft models. The novel kinase inhibitor induced volumetric responses, decreased mitotic activity, and had antiproliferative effects. In models with KIT exon 13 mutation IDRX-42 induced characteristic myxoid degeneration.
Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML
Authors: Letson Christopher T. , Balasis Maria E. , Newman Hannah , Binder Moritz , Vedder Alexis , Kinose Fumi , Ball Markus , Kruer Traci , Quintana Ariel , Lasho Terra L. , Finke Christy M. , Almada Luciana L. , Grants Jennifer M. , Zhang Guolin , Fernandez-Zapico Martin E. , Gaspar-Maia Alexandre , Lancet Jeffrey , Komrokji Rami , Haura Eric , Sallman David A. , Reuther Gary W. , Karsan Aly , Rix Uwe , Patnaik Mrinal M. , Padron Eric 
Published: May 2023

Abstract

Purpose:
Preclinical studies in myeloid neoplasms have demonstrated efficacy of bromodomain and extra-terminal protein inhibitors (BETi). However, BETi demonstrates poor single-agent activity in clinical trials. Several studies suggest that combination with other anticancer inhibitors may enhance the efficacy of BETi.

Experimental Design:
To nominate BETi combination therapies for myeloid neoplasms, we used a chemical screen with therapies currently in clinical cancer development and validated this screen using a panel of myeloid cell line, heterotopic cell line models, and patient-derived xenograft models of disease. We used standard protein and RNA assays to determine the mechanism responsible for synergy in our disease models.

Results:
We identified PIM inhibitors (PIMi) as therapeutically synergistic with BETi in myeloid leukemia models. Mechanistically, we show that PIM kinase is increased after BETi treatment, and that PIM kinase upregulation is sufficient to induce persistence to BETi and sensitize cells to PIMi. Furthermore, we demonstrate that miR-33a downregulation is the underlying mechanism driving PIM1 upregulation. We also show that GM-CSF hypersensitivity, a hallmark of chronic myelomonocytic leukemia (CMML), represents a molecular signature for sensitivity to combination therapy.

Conclusions:
Inhibition of PIM kinases is a potential novel strategy for overcoming BETi persistence in myeloid neoplasms. Our data support further clinical investigation of this combination.
Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Authors: Degnim Amy C. , Siontis Brittany L. , Ahmed Safia K. , Hoskin Tanya L. , Hieken Tina J. , Jakub James W. , Baum Christian L. , Day Courtney , Schrup Sarah E. , Smith Lauren , Carter Jodi M. , Sae Kho Tiffany M. , Glazebrook Katrina N. , Vijayasekaran Aparna , Okuno Scott H. , Petersen Ivy A. 
Published: May 2023

Abstract

Purpose:
To evaluate the impact of trimodality treatment versus monotherapy or dual therapy for radiation-associated angiosarcoma of the breast (RAASB) after prior breast cancer treatment.

Experimental Design:
With Institutional Review Board approval, we identified patients diagnosed with RAASB and abstracted data on disease presentation, treatment, and oncologic outcomes. Trimodality therapy included (i) taxane induction, (ii) concurrent taxane/radiation, and then (iii) surgical resection with wide margins.

Results:
A total of 38 patients (median age 69 years) met inclusion criteria. Sixteen received trimodality therapy and 22 monotherapy/dual therapy. Skin involvement and disease extent were similar in both groups. All trimodality patients required reconstructive procedures for wound closure/coverage, compared with 48% of monotherapy/dual therapy patients (P &lt; 0.001). Twelve of 16 (75%) patients receiving trimodality therapy had a pathologic complete response (pCR). With median follow-up of 5.6 years, none had local recurrence, 1 patient (6%) had distant recurrence, and no patients died. Among 22 patients in the monotherapy/dual therapy group, 10 (45%) had local recurrence, 8 (36%) had distant recurrence, and 7 (32%) died of disease. Trimodality therapy demonstrated significantly better 5-year recurrence-free survival [RFS; 93.8% vs. 42.9%; P = 0.004; HR, 7.6 (95% confidence interval, CI: 1.3–44.2)]. Combining all patients with RAASB regardless of treatment, local recurrence was associated with subsequent distant recurrence (HR, 9.0; P = 0.002); distant recurrence developed in 3 of 28 (11%) patients without local recurrence compared with 6 of 10 (60%) with local recurrence. The trimodality group had more surgical complications that required reoperation or prolonged healing.

Conclusions:
Trimodality therapy for RAASB was more toxic but is promising, with a high rate of pCR, durable local control, and improved RFS.
Manual and Oscillometric Blood Pressure in tPA‐Treated Acute Ischemic Stroke: What Constitutes Agreement?
Authors: Grove Mary A. , Paliwal Mani , Shearin Anne , Kaiser Jane , Koo Eun Sun , Howey Danielle , Galati Michele , Czekalski Bozena , Dumawal Jennifer , DeCarvalho Briana , Dwyer Jackie , Tsivgoulis Georgios , Alexandrov Andrei V. , Alexandrov Anne W. 
Published: May 2023

Background
Automatic noninvasive oscillometric blood pressure (NIBP) devices measure mean arterial pressure (MAP); systolic and diastolic blood pressure (SBP, DBP) are algorithmically derived from MAP. The most invalid NIBP measure is SBP, yet stroke practitioners use it to manage blood pressure (BP) in accordance with thrombolysis guidelines. We determined agreement between SBP, DBP, and MAP measured manually and by NIBP in patients treated with alteplase.

Methods
A multisite prospective observational study of NIBP and manual BP agreement was conducted in patients treated with alteplase immediately after bolus and infusion initiation using methods established in guidelines for the assessment of device agreement. Dual auscultatory stethoscopes were used by 2 investigators to ensure agreement with each manual BP variable and MAP was calculated using the standard formula for manual BP measures. Data were analyzed using Bland–Altman analyses and Lin concordance correlation coefficient.

Results
A total of 7 hospitals participated, collecting 5 sets of manual/NIBP BPs in 95 patients treated with alteplase (475 paired measures). Range in limits of agreement were SBP: −28.91 to 21.41 mmHg with Lin's concordance correlation coefficient 0.8; DBP: −21.0 to 19.0 mmHg with Lin's concordance correlation coefficient 0.69; and MAP: −27.5 to 16.5 mmHg with Lin's concordance correlation coefficient 0.7. There was no difference in device agreement by BP device manufacturer brand. Differences in SBP, DBP, and MAP between NIBP and manual sphygmomanometry failed to reach guideline recommendations requiring 80% of measures to fall within a 5 mmHg difference and 95% of measures to fall within a 10 mmHg difference.

Conclusion
NIBP devices produce significantly different BP measures then manual sphygmomanometry auscultated BP. Because NIBP devices rely on the MAP and do not directly measure SBP and DBP, definition of what constitutes safe MAP boundaries in patients treated with alteplase should be determined when automatic BP measurement is used in clinical practice.
Flow Diversion for Intracranial Aneurysms in Large‐Diameter Vessels: A Subanalysis From the SESSIA Study
Authors: Vivanco‐Suarez Juan , Rodriguez‐Calienes Aaron , Farooqui Mudassir , Rabinovich Margarita , Abouelleil Mohamed , Altschul David J. , Feigen Chaim , Fifi Johanna T. , Matsoukas Stavros , Al‐Mufti Fawaz , Malaga Marco , Galecio‐Castillo Milagros , Wakhloo Ajay K. , Singer Justin A. , Ortega‐Gutierrez Santiago 
Published: May 2023

Background
Flow diverters are now considered first‐line tools for treating intracranial aneurysms. However, few devices are available for patients with large‐diameter vessels (LDVs). Hence, we evaluated the performance of the largest diameter Surpass Streamline for aneurysms in LDVs.

Methods
We performed a subanalysis of the SESSIA (Safety and Efficacy of the Surpass Streamline for Intracranial Aneurysms) multicenter cohort study of patients treated with Surpass Streamline between 2018 and 2021. Patients in whom a 5‐mm diameter Surpass Streamline was implanted were divided into 2 groups according to vessel diameter at the landing zones (LDV, ≥5.3 mm versus non‐LDV [N‐LDV], <5.3 mm). Efficacy was complete occlusion at final follow‐up. Safety was ischemic/hemorrhagic events and mortality up to 30 days.

Results

Thirty patients harboring 30 aneurysms were included. Fifteen cases were included per group (LDV versus N‐LDV). Baseline demographics, clinical characteristics, median aneurysm size (LDV, 11 mm versus N‐LDV, 10 mm), and location were similar. Vessel diameters at the proximal (LDV, 5.3 mm versus N‐LDV, 4.2 mm;
P
<0.001) and distal (5.6 versus 4.0 mm;
P
<0.001) flow diverter landing zones were different. Procedural characteristics (including balloon‐assisted angioplasty and stenting) were similar. At the final follow‐up (12±6 months), complete occlusion (LDV, 75% versus N‐LDV, 84%;
P
=0.548), and ischemic/hemorrhagic events (1 per group;
P
=1.00) were not different.

Conclusions
The use of large‐diameter flow diverters for treating complex intracranial aneurysms arising in LDVs is technically feasible and safe. Comparative studies evaluating devices suitable for this patient population will provide valuable insights for the best device selection.
Evaluation of the Relationship Between Radial Artery Intima Media Thickness and Complications at the Intervention Site After Radial Angiography
Authors: Naldemir Ibrahim Feyyaz , Karaman Ahmet Kursat , Güçlü Derya , Koç Ay Esra , Kayapınar Osman , Kaya Adnan , Sarıgedik Enes , Altınsoy Hasan Baki 
Published: May 2023

The present study investigated the relationship between pre-procedural radial intima-media thickness (rIMT) and radial artery thrombosis (RAO) in patients undergoing angiography using a transradial approach (TRA). Patients (n = 90) who underwent cerebral or peripheral arterial angiography using TRA were included in the study. Ultrasonographic evaluation was performed before and 12 h after the procedure. Preoperative rIMT measurement was performed at the distal radial artery. Presence of radial artery occlusion was evaluated by ultrasonography after radial catheterization and revealed occlusive thrombus in the radial artery in 13 patients. rIMT was found to be statistically significantly higher in patients with thrombus ( P < .05). When it was evaluated whether there was a correlation between age and rIMT, a positive significant correlation was found ( P < .01). Our study suggests that increase of rIMT may be a risk factor for RAO in the intervention area. Before the procedure, ultrasound (US) assessment of the radial artery may be useful in determining the risk of occlusion. Thus, RAO-related technical risk factors (procedure time, number of punctures, sheath thickness, etc.) can be managed more carefully in patients having radial angiography.
Nanoclay role in improving compression after impact strength of the carbon/epoxy composites
Authors: Fakhreddini-Najafabadi Sajjad , Torabi Mahdi , Taheri-Behrooz Fathollah 
Published: May 2023

Polymer matrix composites are vulnerable to low-velocity impact, although they have found many applications in high-tech industries. The main objective of this study is to improve compression after impact strength of the carbon/epoxy composites using nanoclay particles. All test samples were fabricated using a vacuum infusion process. The solution blending methodology was applied for better dispersion of the nanoparticles in the resin. The low-velocity impact response of the composite and nanocomposite laminates was investigated at various energy levels of 10, 15, and 20 J. To quantify the impact effect, the residual strength of the impacted specimens was experimentally measured under the compression test. In addition, the effect of nanoclay incorporation through the solution blending methodology on damage mechanisms was determined by the radiographic analyses and optical microscope method. The findings of this research showed a rise, up to 25.15% in the residual compressive strength, and a 7-fold increase in local buckling threshold stress of the carbon/epoxy/nanoclay specimens.
Drilling of banana stem fibers and polyurethane derived from castor oil composite
Authors: Ellenberger Alessandro , Polli Milton Luiz , Cristina de Azevedo Elaine , Pereira de Paula Caroline Rodrigues 
Published: May 2023

Natural fibers composites obtained from waste of agricultural processes appear as an alternative to materials from non-renewable sources. Drilling these composites is challenging due to the non-homogeneous structure and behavior of the natural fibers and the polymeric matrix. This work uses different drill types and machining parameters to investigate the drilling process in a composite with banana stem fibers and polyurethane derived from castor oil. Hole damages, thrust force, torque and chip morphology were evaluated. The best results were found using a twist drill at 19 m/min cutting speed and 0.1 mm/rev feed rate. Drill type was the main factor in generating damage in the holes, while torque and thrust force were less influential.
Listening to Preferred and Loud Music Enhances Taekwondo Physical Performances in Adolescent Athletes
Authors: Ouergui Ibrahim , Jebabli Eya , Delleli Slaheddine , Messaoudi Hamdi , Bridge Craig Alan , Chtourou Hamdi , Franchini Emerson , Ballmann Christopher Garrett , Ardigò Luca Paolo 
Published: May 2023

In this study, we aimed to investigate the effects of warm-up music preference and loudness on physical performance, perceived exertion (RPE), and enjoyment in young taekwondo athletes. In a crossover counterbalanced design, 20 taekwondo athletes (10 male, 10 female) performed a battery of physical tasks specific to taekwondo under the following five conditions: (a) No music (NM), (b) Preferred music-Soft (60 dB; PMS), (c) Preferred music-Loud (80 dB; PML), (d) Non-preferred music-Soft (60 dB; NPMS), and (e) Non-preferred music-Loud (80 dB; NPML). On each lab visit, participants completed a taekwondo-specific agility test (TSAT), a10-second kick test (KSKT-10s) and a multiple frequency speed of kick tests (FSKT) within each music condition. Pre-exercise enjoyment was assessed using the Physical Activity Enjoyment Scale (PACES) after the warm-up, while we obtained RPE scores after each test. The PML condition resulted in significantly better agility test times on the TSAT compared to PMS ( p < .001), and NPML ( p < .001). Furthermore, PML led to a greater number of total kicks during the FSKT-10s test compared to the PMS ( p < .001), and NPML ( p < .001) conditions. The decrement index on the FSKT was lower in PML than in PMS and NPML conditions ( p < .001). For RPE, values were significantly lower with preferred than non-preferred music ( p < .001). These findings lend support to ergogenic benefits of listening to PML prior to taekwondo physical tasks, with important implications for enhancing taekwondo training and performance.
The association between psychological resilience and hair cortisol concentration in adults: A systematic review and meta-analysis
Authors: Xiang LiWen , Zeng Xia , Luo YinXia , Tan SuFang , Wang Fang , Mao XiaoRong 
Published: May 2023

Background Resilience measures are typically based on subjective self-assessment, which is prone to bias. Objective biological/physiological measures of resilience are therefore needed. Hair cortisol concentration is a particularly promising candidate as a biomarker for resilience. Methods We conducted a meta-analytic review from inception to April 2023 in PubMed, EMBASE, Cochrane Library, and Psych Info databases. All data were analyzed using a random-effects model. Results Eight studies were identified that included a total of 1,064 adults. The random effects model demonstrated that resilience and hair cortisol concentration were inversely correlated (r = −0.18, 95% confidence interval [CI] = −0.27 to −0.09) with substantial heterogeneity ( I2 = 54.2%, p = 0.03). The inverse association was stronger in those who were age 40 years or younger compared to those who were over 40 years. The correlation coefficients between psychological resilience and hair cortisol concentration among adults assessed by different resilience measures were r = −0.29 (95% CI = −0.49 to −0.08) for the CD-RISC-10; r = −0.21 (95% CI = −0.31 to −0.11) for the CDRISC- 25, and r = −0.08 (95% CI = −0.22 to 0.06) for the BRS. Six of eight studies examined the connection between resilience and perceived stress, where the weighted mean correlation coefficient was r = −0.45 (95% CI = −0.56 to −0.33), with considerable heterogeneity ( I2 = 76.2%, p = 0.001). Conclusions There is a negative association between psychological resilience and hair cortisol concentration based on these eight studies. Additional research, particularly prospective studies, is needed to determine whether hair cortisol concentration can be used as a biomarker for psychological resilience.