bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creation of a theoretically rooted workbook to support implementers in the practice of knowledge translation
Authors: Fahim Christine , Courvoisier Melissa , Somani Nadia , De Matas Fatiah , Straus Sharon E. 
Published: August 2023

Abstract
Background
Few training opportunities or resources for non-expert implementers focus on the “practice” as opposed to the “science” of knowledge translation (KT). As a guide for novice implementers, we present an open-access, fillable workbook combining KT theories, models, and frameworks (TMFs) that are commonly used to support the implementation of evidence-based practices. We describe the process of creating and operationalizing our workbook.

Methods
Our team has supported more than 1000 KT projects and 300 teams globally to implement evidence-based interventions. Our stakeholders have consistently highlighted their need for guidance on how to operationalize various KT TMFs to support novice implementers in “practising” KT. In direct response to these requests, we created a pragmatic, fillable KT workbook. The workbook was designed by KT scientists and experts in the fields of adult education, graphic design, and usability and was piloted with novice implementers. It is rooted in an integrated KT approach and applies an intersectionality lens, which prompts implementers to consider user needs in the design of implementation efforts.

Results
The workbook is framed according to the knowledge-to-action model and operationalizes each stage of the model using appropriate theories or frameworks. This approach removes guesswork in selecting appropriate TMFs to support implementation efforts. Implementers are prompted to complete fillable worksheets that are informed by the Theoretical Domains Framework, the Consolidated Framework for Implementation Research, the Behaviour Change Wheel, the Effective Practice and Organization of Care framework, Proctor’s operationalization framework, the Durlak and DuPre process indicators, and the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework. As they complete the worksheets, users are guided to apply theoretically rooted approaches in planning the implementation and evaluation of their evidence-based practice.

Conclusions
This workbook aims to support non-expert implementers to use KT TMFs to select and operationalize implementation strategies to facilitate the implementation of evidence-based practices. It provides an accessible option for novice implementers who wish to use KT methods to guide their work.
Tirzepatide in Hispanic/Latino Patients With Type 2 Diabetes: A Subgroup Analysis of the SURPASS Program
Authors: Frías Juan Pablo , Galindo Rodolfo J , Wang Hui , Malik Raleigh E , Chivukula K Karthik , Maldonado Juan M 
Published: August 2023

Abstract

Context
Efficacy and safety of tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, have been studied in patients with type 2 diabetes in the global phase 3 SURPASS program.

Objective
This work aimed to assess the efficacy and safety of tirzepatide in Hispanic/Latino and non-Hispanic/Latino patients in SURPASS-1 to -4 clinical trials.

Methods
A total of 5679 patients were included, 2895 of self-reported Hispanic/Latino ethnicity, in this exploratory analysis of SURPASS-1 to -4 trial data. Interventions included tirzepatide 5, 10, or 15 mg, placebo, or active comparator (semaglutide 1 mg, insulin degludec, and insulin glargine). Change in glycated hemoglobin A1c (HbA1c) and body weight from baseline to week 40 (SURPASS-1 and -2) and to week 52 (SURPASS-3 and -4), and other efficacy and safety outcomes were evaluated within Hispanic/Latino and non-Hispanic/Latino subgroups.

Results
Among Hispanic/Latino and non-Hispanic/Latino patients treated with tirzepatide, respectively, HbA1c decreased significantly from baseline, ranging from 1.9% to 2.7% and 1.7% to 2.5%, and body weight decreased significantly from baseline, ranging from 5.3 kg to 12.4 and 6.5 kg to 17.1 kg (both P &lt; .05) vs comparators across all trials. Subgroup trends were consistent with the overall trial populations. Treatment-emergent adverse events were reported in similar proportions across the subgroups and were primarily gastrointestinal disorders. The incidence of hypoglycemia was low.

Conclusion
Tirzepatide significatively reduced HbA1c and body weight in Hispanic/Latino and non-Hispanic/Latino patients. Tirzepatide was generally well tolerated in both subgroups. Efficacy and safety trends were comparable between subgroups and within the overall trial populations.
The Economic Assimilation of Second-Generation Men: An Analysis of Earnings Trajectories Using Administrative Records
Authors: Villarreal Andrés , Tamborini Christopher R. 
Published: August 2023

Abstract
Previous research on the economic assimilation of recent U.S.-born children of immigrants who form the new second generation has disproportionately focused on their educational attainment and other early-life outcomes. In this study, we examine the earnings trajectories of second-generation men through a large part of their adult lives using a unique dataset that links respondents from more than two decades of the Current Population Survey to their longitudinal tax records. This longitudinal information allows us to compare the progress second-generation men of different race and ethnicity make in narrowing the earnings gaps with later generations. We consider the extent to which differences in educational attainment and in early occupational placement affect the earnings trajectories of second-generation men. New second-generation men as a whole experience considerable earnings mobility during their lifetimes. However, we also find large differences by race and ethnicity that cannot be fully explained by educational attainment. Second-generation Hispanic men in particular begin their careers with an earnings deficit relative to later-generation White men and fall further behind. Thus, the stalling or reversal in Hispanic economic assimilation appears to begin during the course of the second generation rather than in later generations as previously thought.
Cervical and Lumbar Disk Replacement in Athletes: Is It Safe to Return to Play? A Systematic Review of the Scientific Literature and Lay Press
Authors: Jo Jacob , Davidar A. Daniel , Hersh Andrew M. , Theodore Nicholas , Zuckerman Scott L. 
Published: August 2023

BACKGROUND AND OBJECTIVES:
Cervical/lumbar total disk replacements (TDRs) are often performed for degenerative conditions but rarely in athletes. Therefore, we sought to conduct a systematic review of athletes undergoing TDRs of both the scientific literature and lay press, with an emphasis on contact sport athletes.

METHODS:
In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, PubMed/Embase/Cochrane/Scopus/Web of Science databases were queried for all primary literature reporting TDRs in athletes, including both cervical/lumbar disk replacements (CDRs/LDRs). Sports were dichotomized into contact vs limited/noncontact. Because of the public nature of injuries in elite athletes, the lay press was also queried.

RESULTS:
A total of 488 scientific studies were screened, of which 10 met inclusion criteria. Cervical: seven studies reported CDRs in 53 athletes, of which 7 were professional, 22 semiprofessional, and 24 recreational. Of the seven professional athletes, there was one contact sport athlete (kickboxer). All 7/7 professional and 21/22 semiprofessional athletes successfully returned-to-play at 8-52 weeks without complication. Lumbar: Three studies discussed LDRs in 51 athletes, of which 17 were professional, 6 semiprofessional, and 28 recreational. Of the 17 professional athletes, eight played contact sports (2 boxing, 2 alpine skiing, 2 soccer, judo, rugby). All 17 professional and 6 semiprofessional athletes successfully returned to play at 9–21 weeks. Lay Press: five professional contact sport athletes underwent CDRs, and all returned to play: 3 hockey, 1 mixed-martial arts, and 1 Australian-rules football.

CONCLUSION:
The scientific literature and lay press revealed 14 professional contact sport athletes who underwent TDR—6 CDRs and 8 LDRs—all with successful return to play. From the little data that exist, it seems that TDR may be safe in elite athletes; however, the small number of patients highlights the major paucity of data on the safety of TDR in elite contact sport athletes.
The Impact of Interhospital Transfer on the Extent of Neurological Recovery in Acute Traumatic Spinal Cord Injury: Analysis of a Prospective Multicenter Data Set in 970 Cases
Authors: Bak Alex B. , Moghaddamjou Ali , Harrop James S. , Aarabi Bizhan , Fehlings Michael G. 
Published: August 2023

BACKGROUND AND OBJECTIVES:
Interhospital transfer from community hospitals to centers specialized in managing traumatically injured individuals can strain patients, healthcare systems, and delay appropriate care. The purpose was to compare long-term neurological outcomes in transferred or directly admitted patients with traumatic spinal cord injury (SCI).

METHODS:
An ambispective cohort study was conducted using prospectively collected data (between 2005 and 2018) from 11 specialized level 1 trauma centers across the United States and Canada. All patients who underwent surgical management for SCI were included and placed into 2 comparison cohorts: (1) direct admission and (2) transfer from intermediate hospital. Outcomes were change in American Spinal Injury Association Impairment Scale grade and its components: upper-extremity motor, lower-extremity motor, pinprick, and light touch scores from baseline (assessed ≤72 hours after injury) to follow-up (12-52 weeks). Nearest-neighbor 1:1 propensity score matching between the transferred and directly admitted cohorts was performed. Paired analysis using McNemar's test and paired Student's t-test was used to determine the extent of the difference in neurological outcomes.

RESULTS:
Nine hundred seventy patients (55.5% male, 55.2 ± 18.9 years) with traumatic SCI were directly admitted to a specialized trauma center (N = 474, 48.9%) or transferred from an intermediate hospital (N = 496, 51.1%). After propensity score matching, 283 pairs were matched. Compared with a matched cohort of transferred patients, American Spinal Injury Association Impairment Scale grade improved more in directly admitted patients (56.2% vs 46.3%, P = .024), as did upper-extremity motor score (13.7 ± 12.8 vs 10.4 ± 11.5, P = .018) and light touch score (22.0 ± 29.7 vs 16.9 ± 26.6, P = .034).

CONCLUSION:
Patients with SCI directly admitted to specialized trauma centers have greater neurological recovery compared with patients transferred from an intermediate hospital. Feasibility of direct admission to a center specialized in the management of acute SCI through implementation of a standardized code program must be further investigated.

LEVEL OF EVIDENCE:
Therapeutic level II.
Bidirectional multiciliated cell extrusion is controlled by Notch-driven basal extrusion and Piezo1-driven apical extrusion
Authors: Ventrella Rosa , Kim Sun K. , Sheridan Jennifer , Grata Aline , Bresteau Enzo , Hassan Osama A. , Suva Eve E. , Walentek Peter , Mitchell Brian J. 
Published: August 2023

ABSTRACT
Xenopus embryos are covered with a complex epithelium containing numerous multiciliated cells (MCCs). During late-stage development, there is a dramatic remodeling of the epithelium that involves the complete loss of MCCs. Cell extrusion is a well-characterized process for driving cell loss while maintaining epithelial barrier function. Normal cell extrusion is typically unidirectional, whereas bidirectional extrusion is often associated with disease (e.g. cancer). We describe two distinct mechanisms for MCC extrusion, a basal extrusion driven by Notch signaling and an apical extrusion driven by Piezo1. Early in the process there is a strong bias towards basal extrusion, but as development continues there is a shift towards apical extrusion. Importantly, response to the Notch signal is age dependent and governed by the maintenance of the MCC transcriptional program such that extension of this program is protective against cell loss. In contrast, later apical extrusion is regulated by Piezo1, such that premature activation of Piezo1 leads to early extrusion while blocking Piezo1 leads to MCC maintenance. Distinct mechanisms for MCC loss underlie the importance of their removal during epithelial remodeling.
Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo
Authors: Ho Emily K. , Oatman Harrison R. , McFann Sarah E. , Yang Liu , Johnson Heath E. , Shvartsman Stanislav Y. , Toettcher Jared E. 
Published: August 2023

ABSTRACT
Positional information in development often manifests as stripes of gene expression, but how stripes form remains incompletely understood. Here, we use optogenetics and live-cell biosensors to investigate the posterior brachyenteron (byn) stripe in early Drosophila embryos. This stripe depends on interpretation of an upstream ERK activity gradient and the expression of two target genes, tailless (tll) and huckebein (hkb), that exert antagonistic control over byn. We find that high or low doses of ERK signaling produce transient or sustained byn expression, respectively. Although tll transcription is always rapidly induced, hkb converts graded ERK inputs into a variable time delay. Nuclei thus interpret ERK amplitude through the relative timing of tll and hkb transcription. Antagonistic regulatory paths acting on different timescales are hallmarks of an incoherent feedforward loop, which is sufficient to explain byn dynamics and adds temporal complexity to the steady-state model of byn stripe formation. We further show that ‘blurring’ of an all-or-none stimulus through intracellular diffusion non-locally produces a byn stripe. Overall, we provide a blueprint for using optogenetics to dissect developmental signal interpretation in space and time.
Navigating a research career with a disability
Authors: Anbuhl Kelsey L. , Cazares Oscar , Hubert Katharine A. , Mahapatra Riya , Morgan Jack D. 
Published: August 2023

ABSTRACT
In recent years, we have seen an increasing focus in the academic environment on equity, diversity and inclusion. However, one broad group often left out of these discussions are disabled scientists/scientists with disabilities, who often face severe challenges entering the research profession and navigating their careers. Building on the success of the 2022 Young Embryologist Network's meeting, which included a session on ‘Working in science with a disability’ ( Morgan, 2023) we learn here from the lived experiences of five biologists who share the challenges and successes of undertaking a scientific career with a disability, as well as accommodations that can make science, technology, engineering, mathematics and medicine (STEMM) careers more accessible and inclusive.
A non-invasive, concealed electrocardiogram and bioimpedance measurement system for captive primates
Authors: Serrano-Finetti Ernesto , Hornero Gemma , Mainar Sergio , López Francisco , Crailsheim Dietmar , Feliu Olga , Casas Oscar 
Published: August 2023

ABSTRACT
Captive housed non-human primates, specifically great apes such as chimpanzees (Pan troglodytes) are frequently reported to have died from or are diagnosed with potentially fatal heart conditions that require the monitoring of physiological signals such as electrocardiogram (ECG) or respiratory rate. ECG screening must be conducted after applying full anaesthesia, causing potential physical and emotional stress as well as risk for the animal. Here, we present an electronic system that simultaneously measures the ECG and the electrical bioimpedance for the early detection of abnormal cardiovascular activity. Modified gloves whose fingers are equipped with electrodes enable the caregiver to obtain three cardiovascular signals (ECG, pulse rate and respiratory rate) by placing the fingertips on specific parts of the non-human primate without needing any prior physical preparations. Validation (ECG and bioimpedance) was performed both on humans and on captive housed chimpanzees, where all the signals of interest were correctly acquired.
The Intermediate Water Concept for Pioneering Polymeric Biomaterials: A Review and Update
Authors: Nishimura Shin-nosuke , Tanaka Masaru 
Published: August 2023

Abstract
Polymeric biomaterials are often used in water and hydration water molecules with different mobilities, such as non-freezing water, intermediate water, and free water, are formed on their surfaces. These water molecules affect biological responses between the biomaterials and biofluids. It is challenging to control the state of hydration waters by tuning chemical structures of the polymers toward advance of medical fields. This review describes and updates syntheses, analyses, and applications of the polymeric biomaterials based on the intermediate water concept. The concept provides significant opportunities for pioneering polymeric biomaterials.
Creation of (σ+π)-Mixed Delocalization
Authors: Saito Masaichi , Suzuki Takumi , Takahashi Koki , Seko Saya , Furukawa Shunsuke , Fujii Shintaro 
Published: August 2023

Abstract
We design and synthesize compounds bearing a new electronic delocalization system named (σ+π)-mixed delocalization, where a σ-delocalization unit on the periphery of a benzene ring can conjugate with a π-unit of another benzene ring oriented perpendicularly to the former benzene ring. The (σ+π)-mixed delocalization is evidenced by the HOMO structures, the increase in HOMO energy levels and a larger single-molecule conductance, compared to those of reference compounds with no (σ+π)-mixed delocalization.
Adjustable Robust Optimization with Discrete Uncertainty
Authors: Lefebvre Henri , Malaguti Enrico , Monaci Michele 
Published: August 2023

In this paper, we study adjustable robust optimization (ARO) problems with discrete uncertainty. Under a very general modeling framework, we show that such two-stage robust problems can be exactly reformulated as ARO problems with objective uncertainty only. This reformulation is valid with and without the fixed recourse assumption and is not limited to continuous wait-and-see decision variables unlike most of the existing literature. Additionally, we extend an enumerative algorithm akin to a branch-and-cut scheme for which we study the asymptotic convergence. We discuss how to apply the reformulation on two variants of well-known optimization problems, a facility location problem in which uncertainty may affect the capacity values and a multiple knapsack problem with uncertain weights, and we report extensive computational results demonstrating the effectiveness of the approach. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms – Discrete. Funding: This work was supported by the Air Force Office of Scientific Research [Grants FA8655-20-1-7012, FA8655-20-1-7019].
DiversiTree: A New Method to Efficiently Compute Diverse Sets of Near-Optimal Solutions to Mixed-Integer Optimization Problems
Authors: Ahanor Izuwa , Medal Hugh , Trapp Andrew C. 
Published: August 2023

Although most methods for solving mixed-integer optimization problems compute a single optimal solution, a diverse set of near-optimal solutions can often lead to improved outcomes. We present a new method for finding a set of diverse solutions by emphasizing diversity within the search for near-optimal solutions. Specifically, within a branch-and-bound framework, we investigated parameterized node selection rules that explicitly consider diversity. Our results indicate that our approach significantly increases the diversity of the final solution set. When compared with two existing methods, our method runs with similar runtime as regular node selection methods and gives a diversity improvement between 12% and 190%. In contrast, popular node selection rules, such as best-first search, in some instances performed worse than state-of-the-art methods by more than 35% and gave an improvement of no more than 130%. Furthermore, we find that our method is most effective when diversity in node selection is continuously emphasized after reaching a minimal depth in the tree and when the solution set has grown sufficiently large. Our method can be easily incorporated into integer programming solvers and has the potential to significantly increase the diversity of solution sets. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Funding: This work was supported by the Army Research Office [Grant W911NF-21-1-0079]. The views expressed in this study do not represent those of the U.S. Government, the U.S. Department of Defense, or the U.S. Army. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0164 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0164 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Seizure and bilateral external jugular vein distention: a rare manifestation of Stanford type A aortic dissection
Authors: Zbidat Mohamad , Msheiil Botros , Idilbi Nasra 
Published: August 2023

Introduction: Seizure as a sole sign of Stanford Type A aortic dissection (AAD) is mentioned in the medical literature. In this case, AAD was manifested by external bilateral jugular vein distention and generalized seizure. Patients and Methods: A 47-year-old woman presented to the Emergency Department with convulsions in the upper and lower extremities. She was diagnosed with AAD and transferred to a hospital with cardio-thoracic capabilities for surgery. Conclusion: Seizure resulting from aortic dissection has been explained by general cerebral hypoperfusion. However, jugular vein distention could be secondary to increased thoracic pressure, due to compression of the pulmonary artery by the ascending aorta.
Experimental and clinical evidence for DACC-coated dressings: an update
Authors: Rippon Mark , Rogers Alan A , Ousey Karen , Chadwick Paul 
Published: August 2023

Objective: To update the evidence in relation to the use of dialkylcarbamoyl chloride (DACC)-coated wound dressings in the prevention, treatment and management of wounds. Method: PubMed and PubMed Central databases were searched to identify articles published since 2020 describing the experimental and clinical evidence for DACC-coated dressings, and their antimicrobial effect, as well as their impact on the prevention and treatment of infected wounds. The identified articles were then narratively reviewed. Results: The search yielded 113 articles (plus references from ad hoc sources), of which nine met the inclusion criteria. Of the nine included studies, five related to clinical aspects and four were laboratory studies. Conclusion: A number of new studies have provided further evidence for the mode of action of the antimicrobial effect of DACC-coated dressings and its wide spectrum effect (including World Health Organization-prioritised microorganisms). Additional clinical studies have provided evidence of new applications, such as in treating wounds in paediatric patients, and extended the evidence relating to their use in treating surgical site infections. Evidence also shows that DACC-coated wound dressings can aid in the binding of biofilms, and how this technology can align and support antimicrobial stewardship in the prevention of antimicrobial resistance.