bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin Shows Neuroprotection against Oxidative Damage and Alters APP Processing Involving GSK-3β-mediated Protein O-GlcNAcylation
Authors: Wang Zhun , Tao Pei-Fei , Sun Yu-Ying , Song Xi-Jun , Huang Han-Chang 
Published: May 2023

Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease. Senile plaque is one of the pathological hallmarks in the AD brains, and Amyloid-β (Aβ) peptides are the main components in the senile plaque. The amyloidogenic cleavage of Amyloid-β precursor protein (APP) is a key event for Aβ product and further the formation of senile plaque. Recently, O-GlcNAcylation is suggested to regulate the pathways of APP cleavage. The neurotrophic effects of curcumin on AD rat and the mechanisms on APP O-GlcNAcylation and cleavage were investigated in this study. The hippocampal expression of human APPswe (the Swedish mutation of APP) resulted in the decline of learning and memory and the increase of neuronal oxidative damage and Aβ product. Curcumin relieved these AD-like symptoms and altered Aβ secretion. Like PugNAc (an inhibitor of O-GlcNAcase), curcumin upregulated the O-GlcNAcylation level of APP and switched APP cleavage from amyloidogenic pathway to nonamyloidogenic pathway. GSK-3β participated in APP O-GlcNAcylation and its silence through shRNA interference blocked curcumin-induced protein O-GlcNAcylation. These results indicated that curcumin downregulates APP cleavage of amyloidogenic pathway, involving GSK-3β-mediated protein O-GlcNAcylation. This study implied that GSK-3β is a potential target for regulating APP processing in AD treatment.
Submerged friction stir welding of Al/Cu dissimilar metals: revealing the action mechanism of water cooling on intermetallic compounds layer
Authors: Mao Yue , Wu Run , Guo Hanlin , Xiao Xuan , Qin Dingqiang , Fu Li 
Published: May 2023

Abstract
In order to fabricate high-performance dissimilar joints of Al and Cu, it is critical to inhibit the growth of the hard and brittle intermetallic compounds (IMCs) at the Al/Cu interface. Therefore, submerged friction stir welding (SFSW) technology was conducted to join the Al/Cu dissimilar metals. The results revealed that the SFSW process with water cooling distinctly reduced the thickness of interfacial IMCs layer, and finer grains were formed at the Al side in nugget zone of SFSW joint compared to conventional friction stir welding (FSW). The mechanical properties of the joints produced by SFSW were improved. The tensile strength of the SFSW joint reached up to 221.5 MPa, which was 24.02% higher than that of the FSW joint. In addition, the SFSW could change the fracture location of joints, resulting in the fracture in the Al matrix.
Correlation Between Condylar Structure and Temporomandibular Articular Disc Injury in Adolescents
Authors: Ye Hao , Xu Lei , Zhao Zhoujing , Bai Guanghui , Ge Huaizhi 
Published: May 2023

Abstract
Objective: To evaluate the correlation between temporomandibular joint (TMJ) disc injury and condylar structure in adolescents.
Methods: A total of 94 temporomandibular joints were studied in 47 patients who underwent MRI examination of TMJ in our hospital from April 2019 to December 2020, including 32 in the non-displacement group(ND), 22 in the reducible displacement group(RD), and 40 in the non-reducible displacement group(NRD). For them, a 3.0T MRI scan was performed with conventional sequences, as well as 3D-CUBE T2 and T2-mapping sequences. Maximum left-right and antero-posterior diameters of condyles were measured by multi-plane recombination (MPR) on 3D-CUBE T2 sequence images, whose product and quotient were also calculated. Qualitative and quantitative indicators were included for evaluation of articular disc injury. By reading the films of conventional sequences comprehensively, articular disc displacement was qualitatively classified into non-displacement, reducible displacement and non-reducible displacement. The T2 value of the articular disc was measured on the T2-mapping sequence as a quantitative indicator. Four parameters of condylar structure and 2 indicators of articular disc injury were analyzed using descriptive statistics, one-way analysis of variance and Pearson correlation analysis.
Results: There were statistically significant differences in three structural parameters of the condyle (left-right and antero-posterior diameters and their products) among the non-displacement, reducible and non-reducible displacement groups (P<0.001), and the corresponding mean values were ranked in descending order: values in the non-displacement group > values in the reducible group > values in the non-reducible group. The left-right and antero-posterior diameters and their products were slightly positively correlated with the T2 values of the articular disc (r=0.262, r=0.317, r=0.386, P<0.05).
Conclusion: The left-right diameter, antero-posterior diameter and product of the condyle decreased with aggravation of TMJ disc injury, they can be used as the indirect imaging features of temporomandibular disorder.
Health Risk Assessment of Organic Compounds and Heavy Metals in Electronic Cigarettes
Authors: Zhao Siyuan , Zhang Xi , Wang Junji , Lin Jianzai , Cao Deyan , Zhu Meilin 
Published: May 2023

Abstract
E-cigarettes are now very popular in the world. Compared to traditional cigarettes, e-cigarettes are often considered safer and healthier. However, their safety remains controversial and requires further research and regulation. In this study, we aimed to understand the possible hazards to humans of four compounds (formaldehyde, acetaldehyde, acrolein, and acetone) and seven heavy metals (arsenic, cadmium, manganese, lead, copper, nickel, and chromium) contained in e-cigarette liquids and aerosols and perform a health risk assessment. We searched PUBMED, CNKI, and other databases for relevant literature to obtain data on organic compounds and heavy metals in e-cigarette liquids and aerosols, and conducted acute, chronic, and carcinogenic risk assessments of various chemicals by different exposure routes. This study showed that exposure to four organic compounds and seven heavy metals in e-cigarette aerosols and e-liquids can cause varying levels of health risks in humans through different routes, with the inhalation route posing a higher overall risk than dermal exposure and oral intake. Various chemicals at high exposure doses can produce health risks beyond the acceptable range. E-cigarette designers must improve their products by changing the composition of the e-liquid and controlling the power of the device to reduce the health effects on humans.
The Trojan Horse of Inflammation: Extracellular Vesicles and their Functionally Active Receptors
Authors: Tapken Ines , Kroh Keshia , Bhongir Ravi Kiran Varma , Rahman Milladur , Baumgarten Maria , Smeds Emanuel , Neumann Ariane , Veerla Srinivas , Olinder Jon , Thorlacus Henrik , Ryden Cecilia , Bartakova Eva , Holub Michal , Herwald Heiko , Papareddy Praveen 
Published: May 2023

Abstract
Extracellular vesicles (EVs) play a crucial role in intercellular communication by transferring bioactive molecules, including proteins, lipids, nucleic acids, and small metabolites, from donor to recipient cells. As a result, EV fusion leads to the modulation of cellular functions and has an impact on both physiological and pathological processes in the recipient cell. In this study, we investigated the effects of EV fusion on cellular responses to inflammatory signaling. We found that the fusion renders non-responsive cells susceptible to inflammatory signaling, as evidenced by increased NF-κB activation and the release of inflammatory mediators. Our results further show that STXBP1 is essential for the merge and activation of intracellular signaling. Subsequent analysis revealed that EVs transfer their functionally active receptors to target cells, making them prone to an otherwise unresponsive state. EVs in complex with their agonist, require no further stimulation of the target cells to trigger mobilization of NF-kB. While receptor antagonists were unable to inhibit NF-kB activation, blocking of the fusion between EVs and their target cells with heparin mitigated inflammation in mice challenged with EVs. Together, our findings highlight EVs as important mediators for the inductions of systemic inflammatory reactions.
Dynamics Changes and Predication of Ecosystem Services in the Qinghai-Tibet Plateau, China
Authors: Xue Jian , Li Zongxing 
Published: May 2023

Abstract
The Qinghai-Tibet Plateau (QTP) is an important ecological security barrier and a key region for biodiversity conservation in China. Assessing ecosystem services (ESs) on the QTP over long time series is of great significance. In this study, we quantified and analyzed the ESs of the QTP based on modeling combined with multivariate data. The results showed that habitat quality, water conservation, carbon storage and soil retention of the QTP from 1985 to 2020 were generally positive, and the quality of ESs and the distribution of cold hot spots were spatially consistent. The conservation of forest, shrub and grassland on the QTP contributed to the improvement of ESs. The supply capacity of ESs was higher in the southeastern of the QTP while the areas with higher demand were located in the northeast. Based on quadrant division, it was found that the mismatch between supply and demand of ESs of the QTP was mainly "low supply and low demand" and "high supply and low demand". From 2020 to 2050, ESs on the QTP show varying degrees of increase under all scenarios, with greater changes in ESs under the SSP3-7.0 scenario and the slowest growth in ESs under the SSP5-8.5 scenario.
Effectiveness of Virtual Reality in Nursing Education: A Systematic Review and Meta-analysis
Authors: Liu Kai , Zhang Weiwei , Li Wei , Wang Ting , Zheng Yanxue 
Published: May 2023

Abstract
Objective
Virtual Reality (VR) has shown significant potential in transforming nursing education by providing immersive and interactive learning experiences. To systematically evaluate and meta-analyze the effect of virtual reality technology in teaching nursing students.
Methods
Computer searches of PubMed, Web of Science, Wiley Online Library, Zhiwang database, Wanfang database and China Biomedical Literature Service (SinoMed) were conducted to collect randomized controlled trial studies on the use of virtual reality technology for teaching nursing students built up to March 2023, and the Cochrane The quality of the included literature was evaluated using the quality evaluation criteria for randomized controlled trial studies provided in the evaluation manual. Meta-analysis was performed using Review Manager 5.3 software. Results A total of 12 randomized controlled trials including 1167 students were included. Meta-analysis results showed that virtual reality technology could better improve nursing students' theoretical knowledge [SMD = 0.97, 95%CI [0.48,1.46], p < 0.001] and practical skills [SMD = 0.52, 95% CI [0.33,1.46],p < 0.001] compared to other or traditional nursing teaching methods. 95% CI [0.33, 0.71], P < 0.001] and satisfaction [SMD = 1.14, 95% CI [0.85, 1.43], P < 0.001], but there was no significant effect in improving nursing students' critical thinking skills [SMD = 0.79, 95%CI [-0.05,1.64], P = 0.07].
Conclusion
Compared with other or traditional nursing teaching methods, virtual reality can better improve nursing students' theoretical knowledge,practice skill level and satisfaction, but virtual reality technology has no significant advantage in improving acritical thinking skills of nursing students.
Elder relatives in waking life correlated with both elder relatives in dreams and animals in dreams
Authors: Wang Jiaxi , Feng Xiaoling 
Published: May 2023

Abstract
There are dream metaphors that express waking-life experiences indirectly. Animals in dreams has been speculated to be related to dream metaphors. Here we explored if there was correlation between daily diaries related to elder relatives and animals in dreams. Methods: for one day, 270 participants recorded waking-life experiences in daily diaries before sleeping, and recorded their dreams upon waking. Two external judges rated if there were any content related to elder relatives in both daily diaries and dreams, and rated if both daily diaries and dreams contained content related to animals. Results: the frequency for daily diaries related to elder relatives was 19.6%; the frequency for daily diaries related to animals was 2.6%; the frequency for animals in dreams was 13.7%; the frequency for elder relatives in dreams was 21.5%. The most two frequency animals in dreams were dogs and cats. Recording daily diaries related to elder relatives was correlated with both dreaming about elder relatives and dreaming about animals. In addition, recording daily diaries related to animals was correlated with dreaming about animals. Conclusion: Results supported the continuity hypothesis. In addition, some animals in dreams represented elder relatives in waking life metaphorically.
The effect of frailty in pleural disease using the SAIL Databank: a study protocol.
Authors: Verduri Alessia , Carter Ben , Barton Eleanor , Short Roxanna , Maskell Nick A , Hewitt Jonathan 
Published: May 2023

Abstract
Background
Frailty can impact on patient care and its assessment may improve patient management and clinical outcomes. Pleural disease is common and associated with increased mortality and symptoms, but prediction of outcomes is limited and there is currently no evidence available on the relationship between frailty and outcomes in these patients. This protocol describes an observational study which sets out to assess whether frailty correlates with survival and morbidity in patients with malignant or non-malignant pleural disease.
Methods
Participants with a first episode of pleural disease after 1st January 2005 will be identified from the SAIL Databank using ICD-10 read codes. The electronic frailty index (eFI), included within the databank and measured at the time of first diagnosis of pleural disease, will provide stratification of patients by frailty status. Baseline data collection will also include: patient demographics, presence of comorbidities, smoking status, date of death. The eFI will be correlated with clinical outcomes, including survival, index hospitalisation, length of stay, readmissions, total number of hospitalisations. Our primary analysis will be all-cause mortality by eFI, adjusted for age (≤ 64, 65–74, 75–84, and ≥ 85), sex, ethnicity, deprivation score, smoking status, Charlson Comorbidity Index. The secondary analyses will be pleural disease-specific mortality, time to first hospital admission (all-cause and disease-specific), total length of stay, and readmissions. All analyses will be presented as crude and adjusted HR and OR with associated 95% CIs and p values.
Discussion
The aim of this study is to collect targeted data from a large dataset of subjects with a wide range of pleural disease and provide first data of size reviewing the link between frailty and pleural disease. The eFI can be a potential tool to guide clinical decision making in pleural disease.
Trial registration
Retrospectively registered.
Is robotic ventral mesh rectopexy for pelvic floor disorders better than laparoscopic approach at the beginning of the experience? A retrospective single-center study
Authors: DUMAS Clotylde , DUCLOS Julie , NHO Remy LE HUU , FERMO Magali , GOMEZ Emilie , HENIN Aurélia , VAISSE Camille , PIRRO Nicolas , AUBERT Mathilde , MEGE Diane 
Published: May 2023

Abstract
Purpose
To compare perioperative results of laparoscopic and robotic ventral mesh rectopexy for pelvic floor disorders at the beginning of the surgical experience.
Methods
Between 2017 and 2022, the first 30 laparoscopic ventral mesh rectopexies and the first 30 robotic ventral mesh rectopexies at the beginning of the experience of 2 surgeons were retrospectively analyzed. Perioperative (demographic characteristics, surgical indication, conversion rate, operative time), and postoperative (complications, length of stay, unplanned reintervention) data were compared between groups.
Results
Demographic characteristics were similar between groups. Conversion rate was lower (0 vs 17%, p=0.05), but the operative time was significantly longer (192 ±37 vs 153 ±43 minutes, p<0.0001) during robotic procedure when compared with laparoscopic approach. In terms of learning curve, the number of procedures to obtain the same operative time between the 2 approaches was 15.
Postoperative results were similar between groups, in terms of pain (visual analogic scale = 2.5 ±2 vs 4 ±2, p=0.07), morbidity (17 vs 3%, p=0.2), and unplanned reintervention (0 vs 1%, p=0.99). Mean length of stay was significantly reduced after robotic approach when compared with laparoscopic approach (3 ±2 vs 5 ±2.5 days, p<0.01).
Functional results were better after robotic than laparoscopic ventral mesh rectopexy, with higher satisfaction rate (93 vs 75%, p=0.05), and reduced recurrence rate (0 vs 14%, p=0.048).
Conclusion
Despite longer operative time at the beginning of the learning curve, robotic ventral mesh rectopexy was associated with similar or better perioperative results than laparoscopic ventral mesh rectopexy.
Mixed Hypogonadism: A New Type of Hypogonadism
Authors: wu xueyan , Zhang Rui , Yu Bingqing , Wang Xi , Nie Min , Ma Wanlu , Ji Wen , Huang Qibin , Zhu Yiyi , Sun Bang , Zhang Junyi , Zhang Wei , Liu Hongying , Mao Jiangfeng 
Published: May 2023

Abstract
Purpose
Kallmann syndrome is a rare disease characterized by delayed puberty, infertility and anosmia. We report the clinical and genetic characteristics of four patients with Kallmann syndrome who presented with Klinefelter syndrome or primary testicular disease and defined a new type of hypogonadism as mixed hypogonadism.
Methods
Clinical data and examinations were obtained, including laboratory examination and magnetic resonance imagination (MRI) of the olfactory structures. Idiopathic hypogonadotropic hypogonadism (IHH) related genes were screened by next generation sequencing (NGS).
Results
Four patients with Kallmann syndrome were included. Patient 1–3 had co-existence with Klinefelter syndrome and showed hypogonadotropic hypogonadism. Patient 1 was complicated with germinoma. Patient 4 had a history of hypogonadotropic hypogonadism and cryptorchidism, and then gradually converted to hypergonadotropic hypogonadism during follow-up.
Conclusion
Mixed hypogonadism was defined as hypogonadotropic hypogonadism in Klinefelter syndrome or primary testicular disease. Clinicians should be alert to mixed hypogonadism when spermatogenesis induction failed in patients with IHH or gonadotropin levels decrease in patients with Klinefelter syndrome.
Incidental Multiple Myeloma in a Patient with Idiopathic Neuroretinitis: A Case Report
Authors: Joo Taesung , Kim Tae Gi , Moon Sang Woong 
Published: May 2023

Abstract
Background Neuroretinitis is classically defined as a clinical triad of unilateral, painless vision loss, accompanied by optic disc edema and characteristic macular star formation. Dyschromatopsia, relative afferent pupillary defects, and visual field abnormalities may also occur. The causes of neuroretinitis are diverse and can be categorized as infectious, non-infectious, and idiopathic. Formulating a differential diagnosis and careful evaluation are required, owing to the various etiologies and masqueraders.Case presentation A 54-year-old woman presented to the clinic with blurred vision in both eyes. Complete ophthalmic examination revealed optic disc edema with blurred margins and macular exudates, intraretinal edema in the temporal peripapillary area, and subretinal fluid with neurosensory retinal detachment in the macular area. Systemic laboratory investigations showed no signs of infection or inflammation. However, bone marrow suppression was suspected based on the results of the complete blood count test, and the patient was diagnosed with multiple myeloma.Conclusion Although neuroretinitis is rarely accompanied by hematological malignancy, it is important to be mindful of the latter because ophthalmic manifestations are a common feature of hematological malignancies and lesions occur in nearly every ocular structure.
Introducing Braining - Physical Exercise as Adjunctive Therapy in psychiatric care: a Retrospective Cohort Study of a new method.
Authors: Anger Åsa , Wallerblad Anna , Kaaman Leida , Broman Rebecka , Holmberg Johan , Lundgren Tobias , Salomonsson Sigrid , Sundberg Carl Johan , Martinsson Lina 
Published: May 2023

Abstract

Background: Patients with severe mental disorders suffer from higher rates of poor somatic health and have shorter life expectancy than the average population. Physical activity (PA) can treat and prevent several diseases,e.g.cardiovascular and metabolic disorders as well as psychiatric symptoms. It is therefore of utmost importance to develop effective methods to integrate PA into psychiatric care. To meet this need, the PA intervention Braining was developed. This study aims to describe Braining, to assess the number of patients reached by the intervention during the first years of pilot testing, to analyze clinical data in the group of patients participating in Braining 2017-2020 and to assess the intervention. Methods: In this descriptive retrospective study we analyzed data from all patients participating in Braining training sessions ≥ 3 times (n=239), thus called Braining participants. Regular patients at the clinic served as a comparison. Furthermore, medical records were studied for a smaller cohort (n=51), the Braining Pilot Cohort. Results: During the introduction period of Braining, 580 patients attended an information meeting about Braining, or at least one training session. 239 patients participated in ≥ 3 training sessions, considered to be participants of Braining. These Braining participants (n=239), ages 19 to 82, males 23.4%, attended between 3 and 308 training sessions (median 9). The main diagnoses were depression, bipolar disorders, anxiety disorders, PTSD, ADHD, and autism. Number of diagnoses ranged from 0 to 10 (median=2). For the subsample, the Braining Pilot Cohort (n=51), participants attended between 3 and 208 training sessions (median=20). Twelve percent were working full-time, and symptom severity of depression and general anxiety was moderate. Two thirds had ≥ 3 different classes of medication. Regarding metabolic morbidity, 28 had been diagnosed with hypertension, though blood lipids, blood glucose as well as blood pressure were within the normal range. Thirty-seven percent were prescribed Physical Activity on Prescription (PAP) during 2017-2020. One severe adverse event was reported. Conclusions: The Braining intervention reached all age-groups and patients with a wide and representative diagnostic panorama, suggesting that Braining could be a promising and safe method for implementing PA in a psychiatric patient population.