bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microglia-mediated synaptic pruning in the nucleus accumbens during adolescence: A preliminary study of the proteomic consequences and putative female-specific pruning target
Authors: Kirkland J. M. , Patel Ishan , Kopec Ashley M. 
Published: May 2023

ABSTRACTAdolescence is a period of copious neural development, particularly in the ‘reward’ circuitry of the brain, and reward-related behavioral development, including social development. One neurodevelopmental mechanism that appears to be common across brain regions and developmental periods is the requirement for synaptic pruning to produce mature neural communication and circuits. We published that microglia-C3-mediated synaptic pruning also occurs in the nucleus accumbens (NAc) reward region during adolescence to mediate social development in male and female rats. However, both the adolescent stage in which microglial pruning occurred, and the synaptic pruning target, were sex specific. NAc pruning occurred between early and mid-adolescence in male rats to eliminate dopamine D1 receptors (D1rs), and between pre- and early adolescence in female rats (P20-30) to eliminate an unknown, non-D1r target. In this report, we sought to better understand the proteomic consequences of microglial pruning in the NAc, and what the female pruning target might be. To do this, we inhibited microglial pruning in the NAc during each sex’s pruning period and collected tissue for mass spectrometry proteomic analysis and ELISA validation. We found that the proteomic consequences of inhibiting microglial pruning in the NAc were inversely proportional between the sexes, and a novel, female-specific pruning target may be Lynx1.Please note, if this preprint will be pushed further to publication it will not be by me (AMK), as I am leaving academia. So, I’m going to write more conversationally.
Thermohydraulic Effect of Zebra Stripes - Numerical Analysis
Authors: Smolík Vojtěch 
Published: May 2023

AbstractThe function of zebra stripes has many possible explanations. Some researchers suggested zebra stripes are a form of adaptation to high temperatures, allowing to maintain a lower animal body temperature in hot environment. Sunlight radiation creates a temperature difference between cooler white and hotter black stripes. Hypothesis state there are currents of air formed caused by this temperature difference. This hypothesis is examined using the CFD numerical simulation of zebra surface in ANSYS Fluent to uncover the physical phenomenon.
Single-cell transcriptomics reveals that tumor-infiltrating natural killer cells are activated by localized ablative immunotherapy and share anti-tumor signatures induced by immune checkpoint inhibitors
Authors: Liu Kaili , Sadeghipour Negar , Hoover Ashley R. , Valero Trisha I. , Furrer Coline , Adams Jacob , Naqash Abdul Rafeh , Zhao Meng , Papin James F. , Chen Wei R. 
Published: May 2023

AbstractRationaleNatural killer (NK) cells provide protective anti-cancer immunity. However, the cancer therapy induced activation gene signatures and pathways in NK cells remain unclear.MethodsWe applied a novel localized ablative immunotherapy (LAIT) by synergizing photothermal therapy (PTT) with intra-tumor delivering of the immunostimulant N-dihydrogalactochitosan (GC), to treat breast cancer using a mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) mouse model. We performed single-cell RNA sequencing (scRNAseq) analysis to unveil the cellular heterogeneity and compare the transcriptional alterations induced by PTT, GC, and LAIT in NK cells within the tumor microenvironment (TME).ResultsScRNAseq showed that NK subtypes, including cycling, activated, interferon-stimulated, and cytotoxic NK cells. Trajectory analysis revealed a route toward activation and cytotoxicity following pseudotime progression. Both GC and LAIT elevated gene expression associated with NK cell activation, cytolytic effectors, activating receptors, IFN pathway components, and cytokines/chemokines in NK subtypes. Single-cell transcriptomics analysis using immune checkpoint inhibitor (ICI)-treated animal and human samples revealed that ICI-induced NK activation and cytotoxicity across several cancer types. Furthermore, ICI-induced NK gene signatures were also induced by LAIT treatment. We also discovered that several types of cancer patients had significantly longer overall survival when they had higher expression of genes in NK cells that were also specifically upregulated by LAIT.ConclusionOur findings show for the first time that LAIT activates cytotoxicity in NK cells and the upregulated genes positively correlate with beneficial clinical outcomes for cancer patients. More importantly, our results further establish the correlation between the effects of LAIT and ICI on NK cells, hence expanding our understanding of mechanism of LAIT in remodeling TME and shedding light on the potentials of NK cell activation and anti-tumor cytotoxic functions in clinical applications.
The effects of market orientation and market knowledge search on business model innovation: evidence for two distinct pathways
Authors: Ye Jiangfeng , Shi Shunqing , Feng Yanan 
Published: May 2023

PurposeThis investigation seeks to elaborate on how proactive market orientation (MO) and responsive MO motivate firms to conduct business model innovation (BMI) through the breadth of market knowledge search (BMKS) and the depth of market knowledge search (DMKS).Design/methodology/approachBased on the survey data of 259 high-tech firms in the industrial parks of the Yangtze River Delta, this study uses multiple hierarchical regressions to examine the hypotheses and conducts Sobel and bootstrapping methods to further test the mediating effects.FindingsThe findings indicate that the positive effects of proactive and responsive MO on BMI are mediated by BMKS and DMKS. It also shows that proactive MO has a greater impact on BMKS than responsive MO, while responsive MO has a stronger impact on DMKS than proactive MO.Practical implicationsFirms with different MOs can choose different types of market knowledge search to promote BMI, which reminds managers to give attention to the importance of bridging MOs with knowledge search strategies in BMI.Originality/valueThis study introduces a constructive theoretical framework by examining the roles of MO and market knowledge search on BMI. The findings reveal that MO as a key initiating factor and market knowledge search as an important conduit play vital roles in the experimental process of BMI and identify the differential effects of proactive and responsive MO on two types of market knowledge search.
OMNet: Outfit Memory Net for clothing parsing
Authors: Ye Shaoping , Wang Shaoyu , Chen Nuo , Xu An , Shi Xiujin 
Published: May 2023

PurposeExisting clothing parsing methods make little use of dataset-level information. This paper aims to propose a novel clothing parsing method which utilizes higher-level outfit combinatorial consistency knowledge from the whole clothing dataset to improve the accuracy of segmenting clothing images.Design/methodology/approachIn this paper, the authors propose an Outfit Memory Net (OMNet) that augments original feature by aggregating dataset-level prior clothing combination information. Specifically, the authors design an Outfit Matrix (OM) to represent clothing combination information of single image and an Outfit Memory Module (OMM) to store the clothing combination information of all images in the training set, i.e. dataset-level clothing combination information. In addition, the authors propose a Multi-scale Aggregation Module (MAM) to aggregate the clothing combination information in a multi-scale manner to solve the problem of large variance in the scale of objects in the clothing images.FindingsExperiments on Colorful Fashion Parsing Dataset (CFPD) dataset show that the authors' method achieves 93.15% pixel accuracy (PA) and 51.24% mean of class-wise intersection over union (mIoU), which are satisfactory parsing results compared with existing methods such as PSPNet, DANet and DeepLabV3. Moreover, through comparing the segmentation accuracy of different methods for each category, MAM could effectively improve the segmentation of small objects.Originality/valueWith the rise of various online shopping platforms and the continuous development of deep learning technology, emerging applications such as clothing recommendation, matching, classification and virtual try-on system have emerged in the clothing field. Clothing parsing is the key technology to realize these applications. Therefore, improving the accuracy of clothing parsing is necessary.
We are different and yet the same: the role of CEOs’ regulatory focus and attention in SMEs’ innovation orientation preferences
Authors: Glaveli Niki , Galanou Aikaterini , Kolias Georgios , Karamanis Konstantinos 
Published: May 2023

PurposeDrawing upon upper echelon, regulatory focus and attention theories and focusing on SMEs, the purpose of this paper is to answer questions on how the motivational disposition (promotion vs. prevention regulatory focus) of CEOs affects their information search patterns (i.e. search selection and intensity) and consequently organizational level engagement in different types of innovation activities (exploration vs. exploitation).Design/methodology/approachA quantitative study was conducted collecting data from the CEOs of SMEs operating in the dynamic wine and spirits industry in Greece. The data were collected in two independent time streams and the proposed theoretical model was tested by applying OLS regression analysis.FindingsThe current research provides evidence that differences in CEOs’ level of promotion and prevention focus trigger different information search selection and search intensity patterns. Nonetheless, the attention to innovation components act as mediators only in the hypothesized relationships between a CEO's level of prevention and promotion focus and exploration. Paradoxically, filtered through attention to innovation and triggered from the same motive, that is to reduce negative emotions, promotion focus CEOs choose to direct resources to exploitation and avoid investing in exploration, whilst the opposite was supported for prevention focus CEOs.Practical implicationsThe results highlight the important role of a CEO's regulatory focus orientation in promoting diverse attention to innovation patterns and firm-level innovation tendencies towards exploration and/or exploitation.Originality/valueThis study's contributions extend and combine the theories of regulatory focus, UET and attention in the field of managerial/entrepreneurship behavior and innovation. Therefore, they are valuable for understanding the determinants of firm-level innovation choices (exploration vs. exploitation) in SMEs.
The effect of safety climate in workplaces on productive organizational energy of employees: a research in textile industry
Authors: Çevi̇k Taşdemi̇r Derya , Caner Akin Güfte , Durmaz Yakup 
Published: May 2023

PurposeThe aim of this study is to reveal the effects of “safety climate” on “productive organizational energy”, based on the idea that higher energy and productivity will be seen in employees with the improved safety climate in the working environment.Design/methodology/approachIn this study, data were collected using an online questionnaire from 426 employees of small and medium-sized textile enterprises in the Organized Industrial Zone in the Turkish province of Gaziantep. The “easy sampling” method was applied, one of the sampling techniques not based on probability. Multiple linear regression analysis was used to examine the effects of the “Management's perspectives and rules” and “Colleagues and safety trainings” sub-dimensions of the safety climate on the “emotional”, “cognitive” and “behavioral” components of productive energy.FindingsThe findings showed that the safety climate in the workplace positively and significantly affects the productive organizational energy of employees. In addition, it was observed that the management's perspective and rules had a higher impact on productive organizational energy in attitudes towards the safety climate and productive energies of these employees compared to safety pieces of training.Practical implicationsFirst of all, the result of this study and the positive results that the safety climate in organizations might cause have been noted. It has been demonstrated that the productive energies of the employees will increase if the necessary safety climate is established in the enterprises. In addition, despite the importance attached to the safety training of the employees, as a result of the analysis, it has been determined that the management's perspective and rules (ß = 0.61; p < 0.01) have a higher positive effect on the productive energy of the employees. If these situations are considered by the managers, it is expected that the occupational health and safety management strategies created for the employees will contribute to the formation of positive behaviors in the employees.Originality/valueThe driving force of the present study is that, to our knowledge, there has been no research on this issue related to employees who are mentioned as a critical force in solving productivity and whose number is about 26 million in Turkey's population.
From career to “coreer”: SIE and personal transformation in later life
Authors: Myers Barbara , Thorn Kaye 
Published: May 2023

PurposeDespite burgeoning self-initiated expatriation (SIE) research, little attention has been given to the personal development that occurs as a result of the SIE. The authors address this gap, exploring how the SIE undertaken by older women contributes to their longer-term life-path goals. As personal development has barely featured in the SIE literature, the authors must draw from a range of other global mobility experiences as a base for identifying the personal development of the older women.Design/methodology/approachThe paper employs narrative inquiry methodology, drawing on in-depth life story interviews with 21 women aged 50 or more, both professional and non-professional, who had taken a SIE. A five-step narrative process using a story-telling approach was the method of analysis.FindingsThe findings indicate that the existing focus on SIE and the work context in the literature needs to become more holistic to incorporate personal change experienced through the SIE. For these older women, the construct of “career” was increasingly irrelevant. Rather, participants were enacting a “coreer” – a life path of individual interest and passion that reflected their authentic selves. The SIE presented an opportunity to re-focus these women's lives and to place themselves and their values at the core of their existence.Originality/valueThe contributions highlight the need for a broader focus of career – one that moves outside the work sphere and encompasses life transitions and the enactment of more authentic “ways of being”. The authors identify a range of personal development factors which lead to this change, proposing the term “coreer” as one that might shift the focus and become the basis for career research in the future. Further, through the inclusion of a group of older women who were not exclusively professionals, the authors respond to calls to expand the focus of SIE studies.
Impact of leader aggressive humor on employee extra-role behaviors: opposite moderating effects of team identification and professional identification
Authors: Yang Chen , Yang Xiaojiao 
Published: May 2023

PurposeThe purpose of this paper is to investigate the relationship of leader aggressive humor on employee extra-role behaviors of proactivity and creativity by probing feeling ostracized as a mediator and team identification and professional identification as boundary conditions.Design/methodology/approachA survey sample of 347 employees was collected from three technology companies in Sichuan and Guizhou, China. Hierarchical regression analysis and PROCESS macro in SPSS were used to test the hypotheses.FindingsThe results indicate that leader aggressive humor is negatively related to employee extra-role behaviors. Feeling ostracized is an important mechanism linking leader aggressive humor and employee extra-role behaviors and team identification and professional identification moderate the relationship.Practical implicationsOrganizations should make rules to prevent leaders from using aggressive humorous behaviors and encourage coworkers to show more affiliative funny behaviors during breaks to reduce employees' sense of ostracism.Originality/valueBuilding on sociometer theory, this research demonstrates the opposite moderating effects of team identification and professional identification in the effects of leader aggressive humor on feeling ostracized and consequently employee extra-role behaviors.
Are handloom micro-enterprises in India efficient? Estimation based on DEA and bootstrap truncated regression approach
Authors: Dey Bijoy Kumar , Paul Ujjwal Kanti , Das Gurudas 
Published: May 2023

Purpose
Although handloom is a significant source of livelihood for millions of people in India, it performs poorly compared to other sectors of the economy, which may be the root of technical inefficiency. Until now, to measure technical efficiency, no studies have been carried out; therefore, the purpose of this study is to estimate the technical efficiency in the handloom micro-enterprises in India.

Design/methodology/approach
This study includes 427 handloom micro-entrepreneurs from the Indian state of Assam. Using bootstrap truncated regression, the data envelopment analysis (DEA) was used to calculate the technical efficiency and identify the factors responsible for inefficiency.

Findings
The findings of this study reveal that handloom enterprises are 75% pure technically efficient, suggesting room for input reduction. The bootstrap truncated regression results show that education, prior experience, modern technology, ICT, bank loan, training, gender and location significantly influence the technical efficiency of handloom enterprises.

Research limitations/implications
Despite recent advances in the DEA method, this study used a traditional form of DEA. This study used only one output and a limited set of inputs. Better results could have been obtained by expanding the number of inputs and output. Finally, the data for this study has been obtained from a very narrow geographic area. The production practices of the handloom enterprises in other parts of the region and other states might vary considerably.

Practical implications
Technical efficiency measurement has management implications for businesses because it allows entrepreneurs to determine how much less input is required to produce the same output. A meticulous analysis can pinpoint the causes of inefficiency.

Originality/value
This paper aims to make two significant contributions to the extant literature. First, to the best of the authors’ knowledge, no published document has analyzed the technical efficiency of handloom micro-enterprises anywhere in the world. The authors fill this void by systematically analyzing the technical efficiency of the handloom industry in Assam.
Tiered network health plans and changes in physician practice intensity
Authors: Prager Elena , Sinaiko Anna D. 
Published: May 2023

AbstractObjectiveTo examine whether physicians in tiered physician networks where tier assignments are based on “intensity” of care, which is the quantity of resources used per‐episode of care, change their intensity after learning detailed information about how their intensity compares to their peers.Data SourcesAdministrative data on intensity and quality at the physician‐episode level for all physicians included in a tiered physician network offered through the Massachusetts Group Insurance Commission (GIC) in 2010–2015. Data on physicians' share of revenue from GIC patients from the 2012 Massachusetts All‐Payer Claims Database.Study DesignFor 21,086 physicians in seven specialties, we estimate the impact of the dissemination of detailed intensity performance information in 2014 on physician intensity per episode of care overall and decomposed into physician services, facility, and pharmaceutical subcomponents. Intensity outcomes were measured using a standardized price schedule. Using a difference‐in‐differences regression, we compared physicians with high exposure to the tiered network via a large share of their revenue coming from GIC patients (“GIC share”) to physicians who were less exposed. Measures of intensity of care and GIC share were log‐transformed, and models controlled for physician‐episode type fixed effects.Data Extraction MethodsWe linked GIC share to administrative data using National Provider Identifier.Principal FindingsThere were no statistically significant differences in total intensity of care with the informational intervention for physicians in procedure‐based specialties (−0.12 elasticity of intensity per episode with respect to GIC patient share, 95% CI −0.30 to 0.06) or in relationship‐based specialties (0.09, 95% CI −0.15 to 0.33). There were also no differences in intensity of subcomponents of care following the intervention.ConclusionsTiered network incentives had no detectable impact on intensity of care that physicians provided to patients.
Successful resection after first‐line lenvatinib therapy in an advanced thymic carcinoma
Authors: Shimura Masatoshi , Miura Kentaro , Koizumi Tomonobu , Kanda Shintaro , Mishima Shuji , Hara Daisuke , Matsuoka Shunichiro , Eguchi Takashi , Hamanaka Kazutoshi , Uehara Takeshi , Shimizu Kimihiro 
Published: May 2023

AbstractThymic carcinoma is a highly malignant tumor and treatment options are limited. Lenvatinib, a novel multitargeted kinase inhibitor, has recently been approved for the treatment of unresectable thymic carcinoma. There are no reports of complete surgical resection after the administration of first‐line lenvatinib in advanced thymic carcinoma. A 50‐year‐old man visited our hospital because a computed tomography (CT) scan of the chest showed a large thymic squamous cell carcinoma. We suspected malignant pericardial effusion, invasion of the left upper lobe of the lung, and left mediastinal lymph node metastases. The patient was diagnosed with WHO classification stage IVb disease. Lenvatinib therapy was started at 24 mg/day as first‐line therapy. Gradual dose reduction to 16 mg/day was required because of hypertension, diarrhea, and palmar‐plantar erythrodysesthesia syndrome as side effects. Chest CT findings after 6 months of lenvatinib therapy showed reduction of the main tumor, disappearance of the mediastinal lymph node metastases, and pericardial effusion. Complete salvage resection was successfully performed a month after discontinuation of lenvatinib. The patient has been disease‐free for 1 year without adjuvant therapy. Lenvatinib therapy is one of the promising therapeutic options for thymic carcinoma and may make salvage surgery increasingly useful for advanced thymic carcinoma.