bluuebunny/crossref_metadata_2025_split huggingface dataset:
New evidence of metal exchange in Southeast Asia during the Iron Age: based on the scientific analysis of excavated bronze in Vilabouly, Laos
Authors: Yang Zishu , Jiang Zhilong , Luangkhoth Thonglith , Zhou Ranchao , Cui Jianfeng , Li Haichao 
Published: May 2023

Abstract
This study combines several approaches to investigate bronze objects uncovered at the Thengkham East site in Vilabouly in 2018. According to SEM-EDS research, most copper wares are binary alloys of copper and tin. Metallography (OM) studies have demonstrated that generally, the forming technique of copper wares is casting, and the microstructure of extensive annealing is shown in some areas of isolated weapons. The experimental results for this set of samples were consistent with the previously published style of Vilabouly copperware. Comparative investigations suggest that multiple sites within Vilabouly had similar metallurgical industry technology and that there is a possibility of exchanging intermediate goods between mining/ore processing sites and ordinary consuming locations. Lead isotope studies have corroborated the prevailing opinion that during the early Iron Age in Ban Non Wat, central Laos superseded Thailand in supplying copper to various sections of the Indo-China Peninsula. Given Lead isotope analysis also indicate that there had been connections between Thailand, Laos, and Cambodia in the metallurgical industry during the same period, this study provides support for the hypothesis that incorporate northeastern Cambodia into the medium-range interaction zone where central Laos is located.
On a variation of ⊕-supplemented modules
Authors: Kaynar Engin 
Published: May 2023

Abstract
Let R be a ring and M be an R-module. M is called ⊕ss-supplemented if every submodule of M has a ss-supplement that is a direct summand of M. In this paper, the basic properties and characterizations of ⊕ss-supplemented modules are provided. In particular, it is shown that (1) if a module M is ⊕ss-supplemented, then Rad(M) is semisimple and Soc(M) ⊴ M, (2) every direct sum of ss-lifting modules is ⊕ss-supplemented; (3) a commutative ring R is an artinian serial ring with semisimple radical if and only if every left R-module is ⊕ss-supplemented.
MSC Classification: 16D10 , 16D60 , 16D99
Impact of Biomarkers Associated with CD8+ T cells in Idiopathic Pulmonary Fibrosis on LUSC Immune Infiltration and Construction of CeRNA
Authors: Zhao Xiaowan , Hu Yuqi , Cui Ai 
Published: May 2023

Abstract
Background:
Idiopathic pulmonary fibrosis (IPF) has an insidious onset, no apparent symptoms in the early stage, and is easily combined with lung cancer in the late stage with a poor prognosis. Previous studies have found an overlap between the pathogenesis of IPF and lung cancer (LC), and immune infiltration plays an essential role in the development. But there are still no immune-related markers associated with IPF that have an impact on lung squamous cell carcinoma (LUSC) tumor infiltration.
Methods:
The IPF-related datasets GSE53845, GSE107797, and GSE110147 were acquired from the GEO database. WGCNA analyses of the GSE53845 dataset to identify the most relevant modules and candidate hub genes associated with CD8+ T cells. GO and KEGG analysis were performed on all genes within the module. Next, GSE107797 and GSE110147 were used to verify the relationship between candidate hub genes and CD8+ T cells to identify hub genes. The TIMER database was used to analyze the relationship between hub genes and CD8+ T cells in different cancers. UALCAN was used for the pan-cancer analysis of hub genes. And the mRNA expression levels, prognosis, and gene interrelationships of hub genes in LUSC i dentified by GEPIA, TIMER, TarBase v8, OncoLnc, and starBase to construct a ceRNA regulatory network. The role of hub gene expression in tumor immune infiltration was studied using the TIMER and GEPIA. Finally, we performed single-gene GSEA analysis of the hub genes, methylation analysis of the hub genes using the DiseaseMeth database, and protein expression analysis of the hub gene determined by the Human Protein Analysis (HPA) online database.
Results:
WGCNA identified the pink module as the most relevant module for CD8+ T cells and selected seven candidate hub genes. GO analysis and KEGG analysis further validated the IPF and immune correlation. Three hub genes (CCL5, CXorf65, and RASAL3) significantly associated with CD8+ T cells were validated and identified using the GSE107797 and GSE110147 datasets. Hub genes were positively associated with CD8+ T cells in various cancers. In the pan-cancer analysis, low expression of CXorf65 and RASAL3 was associated with poor prognosis in LUSC. In addition, we found that CXorf65 and RASAL3 were significantly and positively correlated with LUSC immune infiltration, immune cell biomarkers and immune checkpoint expression. We successfully constructed the ceRNA network of CXorf65 and RASAL3. CXorf65, RASAL3 methylation levels, and protein expression levels differed in LUSC and normal tissues. Single-gene GSEA analysis further confirmed the involvement of CXorf65 and RASAL3 in multiple immune responses.
Conclusion:
CXorf65 and RASAL3 were significantly associated with CD8+ T cells in IPF and play an impact on LUSC Immune infiltration.
Effect of nutrition education intervention to improve dietary practice and nutritional status among the elderly in Ilu Aba Bor Zone, Southwest Ethiopia
Authors: Eneshi Muluneh Shuremu , Abate Kalkidan Hassen , Lema Tefera Belachew 
Published: May 2023

Abstract

Background: As the world’s aging population grows, nutrition and health issues are becoming a major concern. Malnutrition in the elderly is associated with both short- and long-term negative health outcomes. Theory-based nutritional education helps diminish the challenges related to aging among the elderly.
Objectives: The current study aimed to evaluate the effect of nutrition education intervention on dietary practice and the nutritional status of the elderly.
Study design: A Cluster randomized controlled trial.
Methods: A pretest−posttest cluster randomized controlled trial mediated by social cognitive theory was conducted among 720 elderly selected from two urban and 12 semi-urban areas of Illu Aba Bor zone, southwest Ethiopia from December 1,2021 to May 30,2021. A pre‐tested, structured interviewer‐administered questionnaire was used for data collection. A qualitative 24‐h dietary recall was used to assess dietary diversity, and the Mini nutritional assessment (MNA) tool was used to assess nutritional status. The intervention effect was evaluated using difference‐in‐ difference and generalized estimating equation models.
Results: The mean dietary diversity score differed significantly between the intervention group and the control group (p<0.001). According to the multivariable generalized estimating equations model, the intervention group was 7.7 times (AOR = 7.746, 95% CI: 5.012, 11.973) more likely to consume a diverse diet than the control group. The nutrition status of elderly in the intervention group improved significantly at the end of the intervention (p < 0.001).
Conclusions: This study showed that theory based nutrition education intervention was effective in improving the dietary diversity practice and nutritional status of the elderly. The researchers recommend that more social cognitive-based interventional studies on other behavioral, socio-cultural and environmental aspects of the elderly's dietary diversity behavior be conducted.
Role of Mono- (Ag, Fe) and Bi- (Ag-Fe) metallic nanoparticles on EMI shielding and antimicrobial activity of PVA/ PVP blends - A green approach
Authors: Ramisetti Praveen , Dumpala Madhuri , Danikonda Suresh Kumar , Nampally Bikshamaiah , Katakam Madhukar 
Published: May 2023

Abstract
Plant-mediated solution casting is used to develop eco-friendly biopolymer blend nanocomposites from polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) embedded with Silver (Ag), Ferrous (Fe) monometallic and Silver-Ferrous (Ag-Fe) bimetallic nanoparticles (NPs). These nanocomposites were developed to understand their EMI shielding efficiency and antimicrobial activities, besides evaluating their physical and chemical properties using XRD, FTIR, FESEM, and EDX characterization techniques. The XRD spectra, revealed that the incorporation of nanoparticles into the blend has resulted in reduction the crystalline nature, significantly. For A3F3 it is reduced from 0.38 to 0.24. The results from FESEM, EDAX and the X-ray diffraction, all corroborate the presence of nanoparticles. The TGA tests reveal that the thermal stability of bimetallic composites is greater than that of monometallic composites, with sample A4F2 showing great improvement. The UTM study of mechanical characteristics showed that the addition of nanoparticles to the polymer matrix increased its mechanical strength. Among all nanocomposites, the A5F1 composite has shown higher tensile stress of 85.5 MPa and Young’s modulus of 7579.7 MPa. We examined its efficacy against Escherichia coli and Staphylococcus aureus and Candida albicans as microorganisms. Good antibacterial and antifungal activity was observed. The bimetallic composites demonstrated greater activity than monometallic composites against these bacterial and fungal species. All bimetallic nanocomposites have shown superior, loss due to reflection, loss due to absorption and the total EMI shielding efficiency at X- and Ku- bands. The samples A5F1 and A4F2, shown highest value of total EMI shielding efficiency of 18 and 32 dB at 8 and 16 GHz respectively. Enhanced antimicrobial, EMI shielding efficiency along with their physical properties, makes these nanocomposites suitable for food and medical packaging, coatings and EMI shielding applications.
Bioinformatics-based approach to construct a ceRNA network between periodontitis and hereditary gingival fibroplasia
Authors: li Shanshan , Li Ningli , Ma Jingyuan , Zhai Yuankun 
Published: May 2023

Abstract

Background Hereditary gingival fibromatosis (HGF) is a rare, hereditary oral disease that would cover the crown of teeth, resulting in tooth migration, abnormal occlusion, or psychological issues, mostly seen in children and adolescents. Periodontitis is a chronic inflammatory illness that may lead to bone and tooth loss. While HGF patients with periodontitis often have severe clinical outcomes, its pathogenesis is not fully understood. This study was to construct a competing endogenous RNA (ceRNA) network between HGF and periodontitis using a bioinformatics approach, in order to explore the pathogenesis of these two co-existence diseases.Methods Differentially expressed genes (DEGs) were identified using the Gene Expression Omnibus (GEO) database between HGF and periodontitis. The Search Tool for Interacting Genes (STRING) database was used to retrieve functional intersection parts between overlapping DEGs for constructing the protein-protein interaction (PPI) network analysis. To build a ceRNA network, 6 databases were used to predict the microRNAs(miRNAs) for the above-mentioned top 5 key genes by using R software, and StarBase (v2.0) database was then predicted to acquire the long non-coding RNAs (lncRNAs) that interact with the aforementioned differentially expressed miRNAs.Results 40 intersecting genes were identified through differential expression analysis and the top 5 key targets, including IL6, FLG2, LOR, KRT2, and LCE2B, were recognized as core targets between HGF and periodontitis from the PPI network. A ceRNA network was constructed with 3 mRNAs (IL6, FLG2, and KRT2), 3 miRNAs (hsa-miR-149-5p, hsa-miR-760, and hsa-miR-376c-3p), and 4 lncRNAs (KCNQ1OT1, NEAT1, HELLPAR, LRRC75A-AS1).Conclusion Current results are obtained by bioinformatics approaches, although its accuracy still needs verification by follow-up biological experiments, this novel ceRNA network may help us to reveal the correlation between HGF and periodontitis deeply, provide diagnosis molecular markers, and develop new therapeutic options for patients with HGF and periodontitis in near future.
HAT1 participates in spermatogenesis of Eriocheir sinensis by regulating chromatin aggregation
Authors: Liu Huiting , Tang Yulian , Sun Lishuang , Li Shu , Luo Lvjing , Chen Zhengyu , Li Genliang 
Published: May 2023

Abstract
Chinese mitten crab, Eriocheir sinensis, is a decapod crustacean with a special, non-condensated nucleus in the sperm. Studies has shown that this is closely related to histone modification. To explore the possible role of histone acetyltransferase 1 (HAT1) in the non-condensation mechanism of sperm nucleus and the spermatogenesis of E. sinensis, we took the testis tissues of adult and juvenile crabs as the objects of study and analyzed their biological functions by whole transcriptome sequencing and bioinformatics, then further analyzed the expression and distribution of HAT1 through RT-qRCR, western blotting, and immunofluorescence. The results showed that HAT1 was up-regulated in adult testes compared with in the juvenile ones (n = 3, P < 0.05). Besides, HAT1 was mainly located in the nucleus of the male germ cell of E. sinensis. With the development of spermatogonia, the expression of HAT1 decreased (n = 3, P < 0.05), and the sperm nucleus of E. sinensis also gradually become non-condensed. Bioinformatics analysis shows that HAT1 and proteins such as Asf1b, Chaf1b and Hist1h3f are involved in biological processes such as DNA conformational changes and DNA replication-dependent nucleosome assembly. It follows that HAT1 is an important regulator of maintaining histone acetylation at specific levels. During the spermatogenesis of E. sinensis, HAT1 first loosens the chromatin structure of sperm nucleus by acetylating histone, while the reduction of HAT1 expression in the later stage effectively avoids excessive acetylation, and maintains histone acetylation at a specific level, which protects the nuclear chromatin state of non-condensed sperm and is important in the spermatogenesis of E. sinensis.
Acute pulmonary embolism combined with acute myocardial infarction a s the first manifestation of acute leukemia: a case report
Authors: Zheng Shuzhan , Luo Sha , Luo Yong , Liu Dan , Zheng Wenwu , Peng Qing 
Published: May 2023

Abstract
Thrombotic complications in acute myeloid leukemia (AML) are uncommon due to coagulation dysfunction and thrombocytopenia. We report a unique case of AML presenting as concomitant pulmonary embolism and atypical acute myocardial infarction. A 67-year-old male experienced persistent bilateral chest pain. Despite an unremarkable electrocardiogram, elevated D-dimer and mildly increased troponin T levels prompted further investigation, leading to the diagnosis of simultaneous pulmonary embolism and acute myocardial infarction. The patient underwent percutaneous coronary intervention and received triple antithrombotic therapy. However, antithrombotic therapy was discontinued following a sharp decline in hemoglobin and platelet counts, and the patient subsequently developed persistent fever. AML was diagnosed via bone marrow biopsy. Chemotherapy was not initiated due to the patient's deteriorating condition, and he ultimately succumbed to presumed intracranial bleeding.
Bag3 protects chondrocytes and alleviates osteoarthritis by restoring autophagy flux
Authors: Wu Jingtao , Yu Heng , Lin Binghao , Zhou Liwen , Wang Jingquan , Cheng Teng , Zhang Zhao , Lin Zhen , Lin Zhongke 
Published: May 2023

Abstract

ObjectiveChondrocyte apoptosis resulting from the inhibition of autophagic flux is a significant contributor to Osteoarthritis (OA). In recent years, there has been increasing interest in the role of Bcl-2-associated athanogene 3 (Bag3) in autophagy; however, its specific contribution to the pathogenesis of knee osteoarthritis remains unclear.MethodsX-ray imaging and tissue staining techniques were used to evaluate the radiographic and histomorphological features of the mouse knee joint. Western blotting was employed to analyze gene and protein expression levels in an in vitro setting. Immunofluorescence staining was utilized to identify and visualize specific proteins in the tissue samples. Knockdown and overexpression techniques were employed to manipulate the expression level of BAG3, a protein of interest. DMM (destabilization of the medial meniscus) was used to induce osteoarthritis in mice for studying the effects of Bag3 overexpression on OA development.ResultsThe results of these experiments showed that in mouse knee OA tissue, BAG3 was upregulated compared to healthy tissue. Knockdown and overexpression experiments of BAG3 revealed a potential anti-apoptotic and autophagy-enhancing function of BAG3 in the context of osteoarthritis. CQ treatment reversed BAG3-induced chondrocyte protection under oxidative stress. Bag3 overexpression ameliorated DMM-induced OA development in mice.ConclusionBag3 alleviates chondrocytes apoptosis by protecting autophagic flux, thereby improving OA.
Effects of a Virtual Mindful Self-Compassion Training on Mindfulness, Self-Compassion, Empathy, Well-being and Stress in Uruguayan Primary School Teachers During Covid-19 Times.
Authors:   Tamara Liberman1, Bidegain Martín , Berriel Andrea , López Francisco , Ibarra Alexander , Pisani Mikaela , Polero Sol , Brito Gonzalo , Pereira Ana Carolina , López Silvana , Castelló María E. 
Published: May 2023

Abstract

Objectives: This study aimed to assess the effects of a virtual Mindful Self-compassion (MSC) intervention on mindfulness, self-compassion, empathy, stress, and well-being in Uruguayan primary school teachers.
Methods: A quasi-experimental, longitudinal study was conducted with an active control intervention (Kundalini Yoga, KY). Uruguayan volunteer female teachers were randomly assigned to MSC or KY 9-weeks virtual training and completed self-reports and an empathy for pain task (EPT) at pre-, post-training, and follow-up (3 months).
Results: After MSC training, mindfulness (ES: observing= -0.836; non-reactivity= -0.476; total mindfulness= -0.655), self-compassion (ES: self-kindness= 0.745; common humanity= -0.588; mindfulness= -0.487) and self-judgment (ES= -0.463) significantly (p<0.05) increased. Furthermore, perspective-taking increased (ES= -0.505) and personal distress decreased (ES= -0.587), while stress decreased (ES= -0.450) and well-being increased (ES= -0.612) after this training. At follow-up, observing (ES= -0.675) and total mindfulness (ES= -0.757) remained elevated and non-judging increased (ES= -0.667); self-compassion remained elevated (ES= -0.778) and personal distress remained decreased ( ES= -0.857). After MSC training, EPT intentionality comprehension accuracy significantly increased (SE= -0.588).
After training, personal distress was higher in KY than MSC (ES= -0.344), while at follow-up observing (ES= -0.454) and total mindfulness (ES =-0.415) were higher in MSC. No differences between groups were found for the EPT.
Conclusions: Virtual MSC training cultivated mindfulness and self-compassion associated with an increase in well-being and empathy, and a reduction of stress in Uruguayan primary school teachers.
A new condition for the existence of a common fixed point for two commutatingself-mappings
Authors: Deghoul Djamel , Chebel Zoheir 
Published: May 2023

Abstract
In this paper, we prove the existence of a common fixed point for two commuta-tive mappings satisfying and generalizing contractive conditions. We provide a newcondition on one of them which leads us to Juncgk’s theorem. Moreover, we estab-lish the associated Banach theorem. Our results generalize some known results in theliterature.
2010 Mathematics Subject Classi cation: Primary 54H25, secondary 47H10.
Does the high tibial osteotomy change the posterior tibia slope and patellar height？
Authors: Ji Songjie , Zhang Jun , Huang Ye , Zhou Yixin , Jiang Xu , Pan Feng 
Published: May 2023

Abstract
Objective To compare the clinical outcomes of performing a closed tibial high osteotomy with an open osteotomy and the changes in posterior tibia slope and patellar height.
Methods were collected from three hundred and forty patients (440 knees) with high tibial osteotomy performed from January 2019 to January 2020. Forty patients (50 knees) had a lateral closed wedge tibial osteotomy (LCWHTO), and 300 patients (390 knees) had a medial open wedge tibial osteotomy (MOWHTO). The follow-up periods were 20.5 months and 19.9 months, respectively. Both groups evaluated the Lysholm score and joint range of motion (ROM) at the final follow-up visit. Changes in preoperative and postoperative mechanical axis deviation (MAD), proximal medial tibial angle (MPTA), posterior tibial slope (PTS), and M-K index were compared between the two groups of patients.
Results Lysholm scores were 79.6 ± 15. 6 preoperatively and 96. 0 ± 5.0 postoperatively in the LCWHTO group (p < 0.01); 83. 7 ± 16.0 preoperatively and 94. 3 ± 9.1 postoperatively in the MOWHTO group (p < 0.01). ROM was 136.0° ± 8.4° preoperatively and 133.2° ± 10.1° postoperatively in the LCWHTO group (p > 0.05); 136.5° ± 8.4° preoperatively and 135.7° ± 9.3° postoperatively in the MOWHTO group (p > 0.05). the MAD was (26.5 ± 4.1) mm preoperatively and 0.3 ± 2.9 mm postoperatively in the LCWHTO group (p < 0.01); 21.8 ± 6.5 mm preoperatively and − 0.3 ± 2.6 mm postoperatively in the MOWHTO group (p < 0.01) .The MPTA in the LCWHTO group was 75.3°±3.2° preoperatively and 89.5°±2. 4° postoperatively (p < 0.01). 77.1°±3.0° preoperatively and 90.6°±2.7° postoperatively in the MOWHTO group (p < 0.01). M-K index was 0.78 ± 0.08 preoperatively and 0.79 ± 0.07 postoperatively in the LCWHTO group (p > 0.05). 0.78 ± 0.05 before and 0.75 ± 0.05 after surgery in the MOWHTO. 10.8°±3.0° PTS before and 8.1°±3.4° after surgery in the LCWHTO group (p < 0.05); 10.2°± 3.1° preoperatively and 10.9°±4.0° postoperatively (p > 0.05).
Conclusions LCWHTO decreases the PTS and has no effect on patellar height; MOWHTO does not affect the PTS but decreases patellar height. The patient should individualize the choice of the osteotomy.
An easy droplet-generation method using an inserted glass capillary into a microchannel
Authors: Shen Feng , Li Chunyou , Yuan Yongchun , Liu Zhaomiao 
Published: May 2023

Abstract
Droplet microfluidics have received increasing attention over the last decade. This study proposes a facile method for droplet generation in microchannels by vertically inserting a glass capillary into a microfluidic chip. The influences of the capillary insertion depth (0, 60, and 120 µm), capillary inner diameter (50, 75, and 100 µm), and two-phase flow ratios (2–12) on the generated droplet length are investigated. The morphology evolution of the two-phase interface during droplet formation is given in detail, which undergoes three successive stages: head formation, head filling, and neck breakage. Three breakage modes for the droplet neck are identified as the plunger, squeezing, and dripping modes, and the forces acting on the droplets are analyzed. The results indicate that the proposed method can generate droplets stably and robustly. The size is accurately controlled to readily provide droplet generation in microchannels.