bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the systematic introduction of tomosynthesis on breast biopsies: 10 years of results
Authors: La Forgia Daniele , Signorile Rahel , Bove Samantha , Arezzo Francesca , Cormio Gennaro , Daniele Antonella , Dellino Miriam , Fanizzi Annarita , Gatta Gianluca , Lafranceschina Miria , Massafra Raffaella , Rizzo Alessandro , Zito Francesco Alfredo , Neri Emanuele , Faggioni Lorenzo 
Published: May 2023

AbstractDigital Breast Tomosynthesis (DBT) is a cutting-edge technology introduced in recent years as an in-depth analysis of breast cancer diagnostics. Compared with 2D Full-Field Digital Mammography, DBT has demonstrated greater sensitivity and specificity in detecting breast tumors. This work aims to quantitatively evaluate the impact of the systematic introduction of DBT in terms of Biopsy Rate and Positive Predictive Values for the number of biopsies performed (PPV-3). For this purpose, we collected 69,384 mammograms and 7894 biopsies, of which 6484 were Core Biopsies and 1410 were stereotactic Vacuum-assisted Breast Biopsies (VABBs), performed on female patients afferent to the Breast Unit of the Istituto Tumori “Giovanni Paolo II” of Bari from 2012 to 2021, thus, in the period before, during and after the systematic introduction of DBT. Linear regression analysis was then implemented to investigate how the Biopsy Rate had changed over the 10 year screening. The next step was to focus on VABBs, which were generally performed during in-depth examinations of mammogram detected lesions. Finally, three radiologists from the institute’s Breast Unit underwent a comparative study to ascertain their performances in terms of breast cancer detection rates before and after the introduction of DBT. As a result, it was demonstrated that both the overall Biopsy Rate and the VABBs Biopsy Rate significantly decreased following the introduction of DBT, with the diagnosis of an equal number of tumors. Besides, no statistically significant differences were observed among the three operators evaluated. In conclusion, this work highlights how the systematic introduction of DBT has significantly impacted the breast cancer diagnostic procedure, by improving the diagnostic quality and thereby reducing needless biopsies, resulting in a consequent reduction in costs.
Hydrogen Reduction of LiCoO2 Cathode Material: Thermodynamic Analysis, Microstructure, and Mechanisms
Authors: Nuraeni Bintang A. , Avarmaa Katri , Prentice Leon H. , Rankin W. John , Pownceby Mark I. , Rhamdhani M. Akbar 
Published: May 2023

AbstractHydrogen is an alternative reductant to replace carbon for the production of metals. Reduction by hydrogen has advantages compared to carbothermic reduction, such as faster reaction rate and cleaner by-product (water vapor). This study investigated the application of hydrogen reduction for recycling and recovering cobalt and lithium from Li-ion battery cathode material (LiCoO2). The study consisted of thermodynamic simulations of the reactions and microstructure evolution analysis from experimental work to propose mechanisms of the reduction process. The thermodynamic assessment predicted that metallic Co could be generated from 400 °C and was stable up to 1200 °C, but strongly dependent on the molar amount of H2. The final experimental reduction products of lithium and cobalt were found to vary and consisted of Li2O, LiOH, Li2O2 and Co, CoO, Co3O4, respectively. The experimental work revealed that the overall reduction mechanism is uniquely characterized by the reduction temperature. The temperature range of 800 °C to 900 °C offered more benefit as Co could be generated as a larger mass indicating a more progressive reduction. The data and information obtained can help optimize the parameters in the recycling of Li-ion batteries.
Investigation of real-world heparin resistance and anticoagulation management prior to cardiopulmonary bypass: report from a nationwide survey by the Japanese Association for Thoracic Surgery heparin resistance working group
Authors: Ito Koki , Sasaki Konosuke , Ono Minoru , Suzuki Takaaki , Sakamoto Kisaburo , Okamoto Hirotsugu , Katori Nobuyuki , Momose Naoki , Araki Yasuyuki , Tojo Keiichi , Ieko Masahiro , Komiyama Yutaka , Saiki Yoshikatsu 
Published: May 2023

Abstract
Objective
Heparin resistance is often encountered during cardiopulmonary bypass. Heparin dose and activated clotting time target values for the initiation of cardiopulmonary bypass are not yet universally standardized; further no consensus exists on the management of heparin resistance. This study aimed to investigate the current real-world practice on heparin management and anticoagulant treatment for heparin resistance in Japan.

Methods
A questionnaire survey was conducted at medical institutions nationwide with which The Japanese Society of Extra-Corporeal Technology in Medicine members are affiliated, targeting surgical cases with cardiopulmonary bypass performed from January 2019 through December 2019.

Results
Among 69% (230/332) of the participating institutions, the criterion for heparin resistance was defined as “the target activated clotting time value not reached even with an additional dose of heparin administration”. Cases of heparin resistance were reported in 89.8% (202/225) of the responded institutions. Of note, 75% (106/141) of the responded institutions reported heparin resistance associated with antithrombin activity ≥ 80%. Antithrombin concentrate was used in 38.4% (238/619 responses) or third dose of heparin in 37.8% (234/619 responses) for advanced heparin resistance treatment. Antithrombin concentrate was found to be effective in resolving heparin resistance in patients having normal, as well as lower antithrombin activity.

Conclusion
Heparin resistance has occurred in many cardiovascular centers, even among patients with normal antithrombin activities. Interestingly, the administration of antithrombin concentrate resolved heparin resistance, regardless of the baseline antithrombin activity value.
The impact of cellular senescence in human adipose tissue
Authors: Nerstedt Annika , Smith Ulf 
Published: May 2023

AbstractIn the last decades the prevalence of obesity has increased dramatically, and the worldwide epidemic of obesity and related metabolic diseases has contributed to an increased interest for the adipose tissue (AT), the primary site for storage of lipids, as a metabolically dynamic and endocrine organ. Subcutaneous AT is the depot with the largest capacity to store excess energy and when its limit for storage is reached hypertrophic obesity, local inflammation, insulin resistance and ultimately type 2 diabetes (T2D) will develop. Hypertrophic AT is also associated with a dysfunctional adipogenesis, depending on the inability to recruit and differentiate new mature adipose cells. Lately, cellular senescence (CS), an aging mechanism defined as an irreversible growth arrest that occurs in response to various cellular stressors, such as telomere shortening, DNA damage and oxidative stress, has gained a lot of attention as a regulator of metabolic tissues and aging-associated conditions. The abundance of senescent cells increases not only with aging but also in hypertrophic obesity independent of age. Senescent AT is characterized by dysfunctional cells, increased inflammation, decreased insulin sensitivity and lipid storage. AT resident cells, such as progenitor cells (APC), non-proliferating mature cells and microvascular endothelial cells are affected with an increased senescence burden. Dysfunctional APC have both an impaired adipogenic and proliferative capacity. Interestingly, human mature adipose cells from obese hyperinsulinemic individuals have been shown to re-enter the cell cycle and senesce, which indicates an increased endoreplication. CS was also found to be more pronounced in mature cells from T2D individuals, compared to matched non-diabetic individuals, with decreased insulin sensitivity and adipogenic capacity.
Graphical abstract

Factors associated with cellular senescence in human adipose tissue
You have been terminated: robots, work, and taxation
Authors: Akar Gizem , Casalone Giorgia , Zagler Martin 
Published: May 2023

AbstractWe present a three sector OLG model with a homogeneous output good that is produced with traditional or robot technology. The traditional sector produces with labor and capital, whereas the modern sector employs robots instead of labor. Robots and workers are modeled as perfect substitutes to investigate whether economic policy under the harshest assumptions is able to prevent the ascent of a robotized economy. While we find that the transition is inevitable, higher taxes on robots and revenues can slow down the process. We also that the economy will switch from an exogenous growth model based on TFP to an endogenous growth model due to constant returns with respect to reproducible factors of production as it becomes fully robotized.
SIR Model with Vaccination: Bifurcation Analysis
Authors: Maurício de Carvalho João P. S. , Rodrigues Alexandre A. 
Published: May 2023

AbstractThere are few adapted SIR models in the literature that combine vaccination and logistic growth. In this article, we study bifurcations of a SIR model where the class of Susceptible individuals grows logistically and has been subject to constant vaccination. We explicitly prove that the endemic equilibrium is a codimension two singularity in the parameter space $$(\mathcal {R}_0, p)$$

(

R
0

,
p
)

, where $$\mathcal {R}_0$$

R
0

is the basic reproduction number and p is the proportion of Susceptible individuals successfully vaccinated at birth. We exhibit explicitly the Hopf, transcritical, Belyakov, heteroclinic and saddle-node bifurcation curves unfolding the singularity. The two parameters $$(\mathcal {R}_0, p)$$

(

R
0

,
p
)

are written in a useful way to evaluate the proportion of vaccinated individuals necessary to eliminate the disease and to conclude how the vaccination may affect the outcome of the epidemic. We also exhibit the region in the parameter space where the disease persists and we illustrate our main result with numerical simulations, emphasizing the role of the parameters.
Flue Dust Reactions and Sticking Mechanisms in a Copper Flash Smelting Furnace Waste Heat Boiler: A Sampling Study
Authors: Schmidt Amélia , Guy Bradley Martin , Montenegro Victor , Reuter Markus , Charitos Alexandros , Stelter Michael , Richter Andreas 
Published: May 2023

AbstractThe formation of accretion layers within the waste heat boiler is a serious operational concern as it can potentially increase boiler downtime and, hence, limit continuous production. In previous Computational Fluid Dynamics studies, the accretion formation was predicted for an industrial-scale waste heat boiler, using a dust stickiness sub-routine of the model. In this study, a dust sampling campaign was used to validate this stickiness sub-routine. Furthermore, various sticking and reaction mechanisms of flue dust were investigated and compared to thermodynamic predictions. While the results suggest that the sub-routine is valid, the comparison of thermodynamics and species in the samples showed that the chemical reactions of the flue dust did not reach the thermodynamic equilibrium.
Graphical Abstract
The relationship between shape parameters and kurtosis in some relevant models
Authors: Borroni Claudio Giovanni , De Capitani Lucio 
Published: May 2023

AbstractWhen a distributional model is chosen, the analytic relation between its shape parameters and the values taken by some kurtosis indexes, especially if they are unconventional, is rarely known. In addition, different indexes may provide contrasting evidence about the level of global kurtosis, when the parameters of the model are varied. That happens because just few parameters act “plainly” on kurtosis, namely so as to produce consistent modifications of the shape of the graph on both its sides. Many parameters, instead, affect kurtosis along with a change of the skewness of the distribution, that is by “inflating” a single side of the graph (usually a tail) at the expense of the other. Thanks to some relevant examples, this paper tries to provide general indications to recognize the two kinds of parameters above and to interpret their effect on the classical Pearson’s standardized fourth moment and on some lesser known kurtosis indexes. Specifically, it is shown that only a decomposed analysis of indexes can help to understand their apparent contradictions, especially when some of them are too sensitive to changes in the tails. Finally, some applications are provided.
The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells
Authors: Miliński Maciej , Staś Monika , Rok Jakub , Beberok Artur , Wrześniok Dorota 
Published: May 2023

Abstract
Background
Non-steroidal anti-inflammatory drugs have been shown to inhibit the development of induced neoplasms. Our previous research demonstrated that the cytotoxicity of sulindac against melanoma cells is comparable to dacarbazine, the drug used in chemotherapy. The aim of this study was to investigate the mechanism of sulindac cytotoxicity on COLO 829 and C32 cell lines.

Methods
The influence of sundilac on the activity of selected enzymes of the antioxidant system (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)) and the content of hydrogen peroxide as well as the level of proteins initiating (p53, Bax) and inhibiting (Bcl-2) apoptosis were measured in melanoma cells.

Results
In melanotic melanoma cells, sulindac increased the activity of SOD and the content of H2O2 but decreased the activity of CAT and GPx. The level of p53 and Bax proteins rose but the content of Bcl-2 protein was lowered. Similar results were observed for dacarbazine. In amelanotic melanoma cells, sulindac did not cause an increase in the activity of measured enzymes or any significant changes in the level of apoptotic proteins.

Conclusion
The cytotoxic effect of sulindac in the COLO 829 cell line is connected to disturbed redox homeostasis by changing the activity of SOD, CAT, GPx, and level of H2O2. Sulindac also induces apoptosis by changing the ratio of the pro-apoptotic/anti-apoptotic protein. The presented studies indicate the possibility of developing target therapy against melanotic melanoma using sulindac.

Graphical abstract
The influence of free stream turbulence on the development of a wind turbine wake
Authors: Gambuzza Stefano , Ganapathisubramani Bharathram 
Published: May 2023

The wake of an isolated model-scale wind turbine is analysed in a set of inflow conditions having free stream turbulence intensity between 3 % and 12 %, and integral time scales in the range of 0.1–10 times the convective time scale based on the turbine diameter. It is observed that the wake generated by the turbine evolves more rapidly, with the onset of the wake evolution being closer to the turbine, for high turbulence intensity and low integral time scale flows, in accordance with literature, while flows at higher integral time scales result in a slow wake evolution, akin to that generated by low-turbulence inflow conditions despite the highly turbulent ambient condition. The delayed onset of the wake evolution is connected to the stability of the shear layer enveloping the near-wake, which is favoured for low-turbulence or high-integral time scale flows, and to the stability of the helical vortex set surrounding the wake, as this favours interaction events and prevents momentum exchange at the wake boundary which hinder wake evolution. The rate at which the velocity in the wake recovers to undisturbed conditions is instead analytically shown to be a function of the Reynolds shear stress at the wake centreline, an observation that is confirmed by measurements. The rate of production of Reynolds shear stress in the wake is then connected to the power harvested by the turbine to explain the differences between flows at equivalent turbulence intensity and different integral time scales. The wake recovery rate, and by extension the behaviour of the turbine wake in high-integral time scale flows, is seen to be a linear function of the free stream turbulence intensity for flows with Kolmogorov-like turbulence spectrum, in accordance with literature. This relation is seen not to hold for flows with different free stream turbulence spectral distribution; however, this trend is recovered if the contributions of low frequency velocity components to the turbulence intensity are ignored or filtered out from the computation.
Window of Opportunity: War and the Origins of Parliament
Authors: Cox Gary W. , Dincecco Mark , Onorato Massimiliano Gaetano 
Published: May 2023

AbstractTwo important puzzles characterize the development of pre-modern Eurasian polities. First, most rulers convened councils of nobles, but only European monarchs expanded them to create parliaments. Second, war was common throughout Eurasia, but only in Europe did it correlate with the formation of parliaments. We advance a new argument about the emergence of parliaments that accounts for both stylized facts while integrating the literature highlighting the rulers' need to finance wars with that emphasizing the importance of the medieval communal revolution. Using novel data, we document a ‘no communes, no parliaments’ rule: monarchs established parliaments only after they had fostered the creation of self-governing towns (aka communes). We also show that war was a significant predictor of parliamentary births across medieval Europe – but only during a window of opportunity that opened after a polity had experienced the communal revolution.
Pestiferous slugs and their associated nematodes in agricultural fields, greenhouses, and nurseries in Alberta, Canada
Authors: Patuwatha Withanage D.B.M. , Howe D.K. , Richart C.H. , Mc Donnell R.J. , Denver D.R. , Luong L.T. 
Published: May 2023

Abstract
Some slug species are considered a nuisance in agriculture and horticulture worldwide, causing economic losses to growers. Phasmarhabditis is a genus of bacteria-feeding nematodes that can parasitize slugs and snails and thus potentially serve as a biological control agent. Canada had no record of Phasmarhabditis until a survey conducted in 2019 reported a Canadian strain of Phasmarhabditis californica from a single Arion rufus slug. To build on this discovery, we surveyed three major agricultural sites, ten greenhouses, and nurseries in Alberta from June to September 2021 to collect pest slug species and investigate their associated nematodes, specifically P. californica. Slugs were collected from the field and returned to the laboratory to check for emerging nematodes on White traps. We collected 1331 slugs belonging to nine species, with Deroceras reticulatum being the most common. Only 45 (3.38%) slug samples were positive for nematodes, and the majority were identified to species level: Alloionema appendiculatum, Caenorhabditis briggsae, Caenorhabditis elegans, Panagrolaimus subelongatus, and Mesorhabditis spiculigera. We did not isolate P. californica from any of the slugs collected from these survey sites, which included the original site where P. californica was discovered. However, four D. reticulatum slugs retrieved from a residential garden sample were infected with P. californica. These findings suggest the possibility of a fragmented distribution of P. californica across Alberta. Future research should focus on extensively surveying agriculture and horticulture sites and residential gardens in different provinces across Canada.
A systematic review and meta-analysis of stereotactic radiosurgery as a primary treatment in fast-growing vestibular schwannomas
Authors: Shah Faizan , Hamilton Leanne O W , Yiannakis Constantina P , Slim Mohd Afiq Mohd , Kontorinis Georgios 
Published: May 2023

AbstractBackgroundStereotactic radiosurgery has been shown to be an effective method of managing vestibular schwannomas. The primary aim here is to establish the impact of pre-treatment fast-growing vestibular schwannomas on the efficacy of stereotactic radiosurgery.MethodsPubMed, Medline and Embase databases were used. The ROBINS-I (‘Risk Of Bias In Non-randomised Studies - of Interventions’) tool was utilised to assess for risk of bias. Proportionate meta-analysis and sub-analysis for fast-growing tumours were performed to explore the success rate of stereotactic radiosurgery in stabilising or decreasing the tumour burden in vestibular schwannomas.ResultsFour moderate risk studies were included in the analysis. Overall, 91 per cent (95 per cent confidence interval = 0.83–0.97, p < 0.01, I2 = 80 per cent) of the tumours demonstrated successful size reduction or stabilisation following stereotactic radiosurgery. Nevertheless, the efficacy of stereotactic radiosurgery in reducing or stabilising fast-growing vestibular schwannomas decreased by 79 per cent (95 per cent confidence interval = 0.64–0.91, p = 0.11, I2 = 62 per cent).ConclusionStereotactic radiosurgery has a statistically significant success rate in stabilising or decreasing the vestibular schwannoma size. This success rate is diminished in fast-growing vestibular schwannomas.
Recent Tree Mortality Dampens Semi‐Arid Forest Die‐Off During Subsequent Drought
Authors: Norlen Carl A. , Goulden Michael L. 
Published: May 2023

AbstractClimate change is expected to increase drought intensity and frequency, which are commonly predicted will threaten the survival of forests. Most forest die‐off projections assume that recent tree mortality will not alter die‐off severity during subsequent droughts. We tested this assumption by comparing die‐off in semi‐arid conifer forest stands in California that were exposed to a single drought in 2012–2015 (“2nd Drought Only”) with forest stands that experienced drought in both 1999–2002 and 2012–2015 (“Both Droughts”). We quantified die‐off severity as a reduction in the satellite observed Normalized Difference Moisture Index, and cumulative moisture deficit as negative 4‐year Precipitation minus Evapotranspiration (4‐year Pr‐ET overdraft). Here we show that recent tree morality reduces die‐off severity in semi‐arid conifer forests exposed to subsequent drought. Stands in the 2nd Drought Only sample experienced severe die‐off associated with extreme 4‐year Pr‐ET overdraft in 2012–2015. Stands in the Both Droughts sample experienced severe die‐off and 4‐year Pr‐ET overdraft in 1999–2002, but comparatively little 2012–2015 die‐off despite continued 4‐year Pr‐ET overdraft. We interpret this as a dampening effect, where prior tree mortality reduces forest die‐off severity during subsequent drought exposure. As forests continue to experience disturbances linked to climate change, dampening effects will impose a transient, and perhaps long‐term, constraint on the impact of repeated drought.