bluuebunny/crossref_metadata_2025_split huggingface dataset:
SMARCC1 is a susceptibility gene for congenital hydrocephalus with an autosomal dominant inheritance mode and incomplete penetrance
Authors: Hourvitz Noa , Kurolap Alina , Mory Adi , Haratz Karina Krajden , Kidron Dvora , Malinger Gustavo , Baris Feldman Hagit , Yaron Yuval 
Published: August 2023

AbstractA Jewish couple of mixed origin was referred for genetic counseling following termination of pregnancy at 18 weeks of gestation due to severe ventriculomegaly with aqueduct stenosis. Trio exome sequencing revealed a loss‐of‐function heterozygous variant in the SMARCC1 gene inherited from an unaffected mother. The SMARCC1 gene is associated with embryonic neurodevelopmental processes. Recent studies have linked perturbations of the gene with autosomal dominant congenital hydrocephalus, albeit with reduced penetrance. However, these studies were not referenced in the SMARCC1 OMIM record (*601732) and the gene was not considered, at the time, an OMIM morbid gene. Following our case and appeal, SMARCC1 is now considered a susceptibility gene for hydrocephalus. This allowed us to reclassify the variant as likely pathogenic and empowered the couple to make informed reproductive choices.
The impact of intervention modality on students' multiplication fact fluency
Authors: Kromminga Kourtney R. , Codding Robin S. 
Published: August 2023

AbstractWhile an abundance of evidence‐based mathematics interventions are available to support students’ mathematics fluency, research suggests that they are not often implemented within schools. Moreover, national data suggests that most students in the United States are not meeting grade level expectations in mathematics. This underperformance coupled with limited implementation of evidence‐based practices emphasizes the need to provide schools with effective, efficient, and resource friendly interventions to support students’ mathematics achievement. The purpose of this study was to compare the effects of reciprocal peer tutoring, iPad delivered flashcards, and a combined intervention condition on the multiplication fluency of 72 third grade students enrolled in two public schools in the midwestern region of the United States using a randomized pretest–posttest design. Students received 10 min of intervention after their core instruction 4 days per week for 5 weeks. Results suggest that there were few differences between treatment groups on both proximal and distal measures. Moreover, all groups demonstrated significant growth from pre‐ to posttest on proximal measures. Assessment response rates across modalities and student engagement are discussed along with implications for research and practice.
Sources of error in detonation calorimeters and error analysis for neat 2,4,6‐triamino‐1,3,5‐ trinitrobenzene (TATB)
Authors: Sheehe Suzanne , Montgomery Jennifer , Cervantes Octavio 
Published: August 2023

AbstractA calorimeter for measuring heats of detonation at Lawrence Livermore National Laboratory is described. A calibration precision of 0.2 % at the 95 % confidence interval (CI) is reported. Sources of uncertainty are discussed, including nonequivalent sources, which are those arising from differences between calibration and experimental tests. The systematic error due to nonequivalent sources is bounded to 0.19–0.22 % of the measured heat for a standard detonation test where the confinement material is gold. The recommendation is to correct for the systematic error by adding 0.19 % to the reported value and adding 0.03 % to the uncertainty. It is demonstrated that the precision of a detonation test is variable with testing duration because a source of uncertainty resides in the thermodynamic correction factor k6, which accounts for the contribution to heat by stirring; the generated power is additive and therefore highly impacted by total test time. The relative proportion also varies with the magnitude of heat release and sample size, adding variance to the weight of the error arising from the correction factor. A full error analysis based on the described sources of uncertainty is developed. The methodology is applied to a test series on neat 2,4,6‐triamino‐1,3,5‐ trinitrobenzene (TATB), demonstrating an ultimate precision of 0.7 % (single test) for materials testing and a relative standard deviation of 1.8 %.
RNA tertiary structure modeling with BRiQ potential in CASP15
Authors: Chen Ke , Zhou Yaoqi , Wang Sheng , Xiong Peng 
Published: August 2023

AbstractWe describe the modeling method for RNA tertiary structures employed by team AIchemy_RNA2 in the 15th Critical Assessment of Structure Prediction (CASP15). The method consists of the following steps. Firstly, secondary structure information was derived from various manually‐verified sources. With this information, the full length RNA was fragmented into structural modules. The structures of each module were predicted and then assembled into the full structure. To reduce the searching conformational space, an RNA structure was organized into an optimal base folding tree. And to further improve the sampling efficiency, the energy surface was smoothed at high temperatures during the Monte Carlo sampling to make it easier to move across the energy barrier. The statistical potential energy function BRiQ was employed during Monte Carlo energy optimization.
‘I chose to stay for a while’: Aspirations and capabilities in the nonmigration decision making of nurses in the Philippines
Authors: Gotehus Aslaug 
Published: August 2023

AbstractFocusing on Filipino nurses, who are situated in a culture of migration where nursing is seen to pave way for overseas migration, this article explores the (non)migration decision‐making process and the temporal and agentic dimensions of the decision to stay. While regimes of mobility may restrict or enable cross‐border movements through immigration regulations, this article focuses on ongoing processes within the Philippines such as labour market development, family relations and individual considerations. The analysis shows how important events, as well as anticipated events, in aspiring migrants' life cycles impact on their decisions and aspirations. Changes in the local labour market, such as the proliferation of call centres, have provided new opportunities for socioeconomic mobility within the Philippines. This article demonstrates how nonmigration of skilled workers is a complex and multilayered phenomenon. While staying has long been seen as a passive and natural situation, this article, in line with an emerging literature, acknowledges that staying requires agency. Further, nonmigration has an inherent temporal dimension as migration aspirations may change over time.
Microcomputed tomography visualization and quantitation of the pulmonary arterial microvascular tree in mouse models of chronic lung disease
Authors: Schneider Ben , Kopf Katrina W. , Mason Emma , Dawson Maggie , Coronado Escobar David , Majka Susan M. 
Published: August 2023

AbstractPulmonary vascular dysfunction is characterized by remodeling and loss of microvessels in the lung and is a major manifestation of chronic lung diseases (CLD). In murine models of CLD, the small arterioles and capillaries are the first and most prevalent vessels that are affected by pruning and remodeling. Thus, visualization of the pulmonary arterial vasculature in three dimensions is essential to define pruning and remodeling both temporally and spatially and its role in the pathogenesis of CLD, aging, and tissue repair. To this end, we have developed a novel method to visualize and quantitate the murine pulmonary arterial circulation using microcomputed tomography (µCT) imaging. Using this perfusion technique, we can quantitate microvessels to approximately 6 µM in diameter. We hypothesize that bleomycin‐induced injury would have a significant impact on the arterial vascular structure. As proof of principle, we demonstrated that as a result of bleomycin‐induced injury at peak fibrosis, significant alterations in arterial vessel structure were visible in the three‐dimensional models as well as quantification. Thus, we have successfully developed a perfusion methodology and complementary analysis techniques, which allows for the reconstruction, visualization, and quantitation of the mouse pulmonary arterial microvasculature in three‐dimensions. This tool will further support the examination and understanding of angiogenesis during the development of CLD as well as repair following injury.
The reification of identity narratives in teacher–student discourse during an inquiry project
Authors: Garah Lulu , Kapon Shulamit 
Published: August 2023

AbstractWe present a year‐long case study that documents the interactions between a teacher–research–mentor (TRM) and two 11th grade students working in their school laboratory on an extended inquiry project that is part of reformed mandatory requirements for advanced‐level matriculation in physics. Both the students (females) and the TRM (male) are Arab citizens of Israel, and the school is a public Arab school in Israel. Data were collected through videotaped participant observation of authentic working sessions and interviews with the TRM and the students. The analysis combines an ethnographic account with discourse analysis informed by a sociolinguistic approach that aims to answer the following research questions: (1) how are a teacher's identity‐narratives reified in teacher–student discourse in authentic sessions of mentoring students' inquiry? (2) how do they shape students' learning? and (3) how do they emerge from social–historical contexts? The findings problematize the challenges involved in engaging students from nondominant communities in science, technology, engineering, and mathematics learning. The analysis articulates the complexity of this challenge by showing how teachers' identity narratives shape the social construction of student–teacher discourse, generate tensions that undermine successful implementations of reformed learning experiences, and how this vicious cycle is profoundly influenced by the embedding social and historical contexts. The implications for research and practice are discussed.
Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery
Authors: Wang Xijie , Zhang Min , Li Yanan , Cong Hailin , Yu Bing , Shen Youqing 
Published: August 2023

AbstractDendrimers are a family of polymers with highly branched structure, well‐defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers are ideal nanocarriers for delivering anticancer agents due to the explicit study of their characteristics of particle size, charge, and biological properties such as toxicity, blood circulation time, biodistribution, and cellular internalization. Here, the classification, preparation, and structure of dendrimer micelles are reviewed, and the specific functional groups modified on the surface of dendrimers for tumor active targeting, stimuli‐responsive drug release, reduced toxicity, and prolonged blood circulation time are discussed. In addition, their applications are summarized as various platforms for biomedical applications related to cancer therapy including drug delivery, gene transfection, nano‐contrast for imaging, and combined therapy. Other applications such as tissue engineering and biosensor are also involved. Finally, the possible challenges and perspectives of dendrimer micelles for their further applications are discussed.
Deciphering the Space Charge Effect of the CoNiLDH/FeOOH n–n Heterojunction for Efficient Electrocatalytic Oxygen Evolution
Authors: Zhao Pandeng , Fu Shaqi , Luo Yuancong , Peng Cheng , Cheng Lingli , Jiao Zheng 
Published: August 2023

AbstractSpace charge transfer is an effective strategy to regulate the electron density of narrow bandgap semiconductors for enhancing electrocatalytic activity. Herein, the CoNiLDH/FeOOH n–n heterojunction hollow nanocages structure is constructed. The hollow structure provides abundant catalytic active sites and enhances mass transfer. The space charge region in the n–n heterojunction significantly promotes the adsorption of OH− and electron transfer; and the built‐in electric field accelerates the electron transport, optimizes the electronic structure during the catalytic reaction process, and ensures the stability of surface charged active center sites in the heterojunction. Thus, CoNiLDH/FeOOH delivers an excellent oxygen evolution reaction (OER) overpotential of 250 mV to achieve a current density of 10 mA cm−2 with a small Tafel slope of 60 mV dec−1, and superior electrocatalytic durability for 210 h at a high current density. Density functional theory calculations further verify that the space charge effect and built‐in electric field in the n–n heterojunction of CoNiLDH/FeOOH can improve the electron transfer and lower the adsorption energy of OH− and the reaction energy barrier of the rate‐determining step. This work provides a new fundamental understanding of the space charge effect of semiconductor heterojunction during the electrocatalytic process for developing more efficient OER electrocatalysts.
Highly Efficient and Stable Inverted Perovskite Solar Cell Using Pure δ‐FAPbI3 Single Crystals
Authors: Mandal Tarak Nath , Heo Jin Hyuck , Im Sang Hyuk , Kim Woo‐Sik 
Published: August 2023

AbstractPure δ‐formamidinium lead triiodide (δ‐FAPbI3) single crystal for highly efficient perovskite solar cell (PCS) with long‐term stability is prepared by a new method consisting of liquid phase reaction of FAI and PbI2 in N,N‐dimethyl formamide and antisolvent crystallization using acetonitrile. In this method, the incorporation of any impurity into the crystal is excluded by the molecular recognition of the crystal growth site. This pure crystal is used to fabricate α‐FAPbI3 inverted PSCs which showed excellent power conversion efficiency (PCE) due to much‐reduced trap‐states. The champion device exhibited a high PCE of 23.48% under the 1‐Sun condition. Surface‐treated devices with 3‐(aminomethyl)pyridine showed a significantly improved PCE of 25.07%. In addition, the unencapsulated device maintained 97.22% of its initial efficiency under continuous 1‐Sun illumination for 1,000 h at 85 °C in an N2 atmosphere ensuring long‐term thermal and photo stabilities of PSCs, whereas the control device kept only 89.93%.
PARP inhibitor rescues hearing and hair cell impairment in Cx26‐null mice
Authors: Wang Xiaohui , Chen Sen , Qiu Yue , Xu Kai , Bai Xue , Xie Le , Kong Weijia , Sun Yu 
Published: August 2023

AbstractGJB2 (encoding connexin26, Cx26) mutation is the most common genetic cause of hereditary deafness. Cochlear sensory hair cell (HC) death is the core pathologic phenomenon of GJB2‐related deafness. However, mechanism‐based therapy is still obscure. A targeted‐cell conditional Gjb2 knockout mouse model was established in which the Cx26 in Deiters cells and pillar cells were knocked out at birth. We explored the mechanism of HC death caused by deficiency of GJB2 in supporting cells (SCs), which exhibited moderate deafness, early HC death without SCs, and a decrease in distortion product otoacoustic emission. Here, a DNA damage response was observed in HCs during the onset of hearing loss. Apoptosis, necroptosis, and ferroptosis do not contribute to the death of HCs. We identified and demonstrated that parthanatos, a poly‐(ADP‐ribose) polymerase (PARP)‐dependent and caspase‐independent form of cell death, is a mechanism of HC degeneration. Furthermore, we observed that the use of PARP inhibitors effectively alleviated both deafness and HC loss. Our study reveals the specific mechanism of HC death caused by GJB2 deficiency. These findings demonstrate that targeting parthanatos is an HC protective strategy in the prevention of GJB2‐related hereditary deafness.
Magnetic resonance spectroscopy findings of brain olfactory areas in patients with COVID‐19‐related anosmia: A preliminary comparative study
Authors: Nemati Shadman , Haghani Dogahe Mohammad , Saberi Alia , Ramezani Naghi , Kiani Pejman , Yaghubi Kalurazi Tofigh  , Kazemnejad Leili Ehsan , Seddighi Sara , Monsef Abbas 
Published: August 2023

AbstractObjectives2019 novel coronavirus disease (COVID‐19) infection is commonly associated with olfactory dysfunctions, but the basic pathogenesis of these complications remains controversial. This study seeks to evaluate the value of magnetic resonance spectroscopy (MRS) in determining the molecular neurometabolite alterations within the main brain olfactory areas in patients with COVID‐19‐related anosmia.MethodsIn a cross‐sectional study, seven patients with persistent COVID‐19‐related anosmia (mean age: 29.57 years) and seven healthy volunteers (mean age: 27.28 years) underwent MRS in which N‐acetyl‐aspartate (NAA), choline (Cho), creatine (Cr), and their ratios were measured in the anterior cingulate cortex, dorsolateral prefrontal cortex, orbitofrontal cortex (OFC), insular cortex, and ventromedial prefrontal cortex. Data were analyzed using TARQUIN software (version 4.3.10), and the results were compared with an independent sample t‐test and nonparametric Mann–Whitney test based on the normality of the MRS data distribution.ResultsThe mean duration of anosmia before imaging was 8.5 months in COVID‐19‐related anosmia group. MRS analysis elucidated a significant association between MRS findings within OFC and COVID‐19‐related anosmia (Pdisease < 0.01), and NAA was among the most important neurometabolites (Pinteraction = 0.006). Reduced levels of NAA (P < 0.001), Cr (P < 0.001) and NAA/Cho ratio (P = 0.007) within OFC characterize COVID‐19‐related anosmia.ConclusionsThis study emphasizes that MRS can be illuminating in COVID‐19‐related anosmia and indicates a possible association between central nervous system impairment and persistent COVID‐19‐related anosmia.
Whole-pelvic irradiation with boost to involved nodes and prostate in node-positive prostate cancer—long-term data from the prospective PLATIN-2 trial
Authors: Fink C. A. , Wegener D. , Sauer L. D. , Jäkel C. , Zips D. , Debus J. , Herfarth K. , Koerber S. A. 
Published: August 2023

Abstract
Purpose
Node-positive prostate cancer is a potentially curable disease. Definitive radiotherapy to the prostate and lymphatic drainage is an effective treatment option but prospective long-term outcome data are scarce. Thus, the current study aimed to evaluate the toxicity and efficacy of definitive radiation therapy for men with prostate cancer and nodal metastases using modern irradiation techniques.

Methods
A total of 40 treatment-naïve men with node-positive prostate cancer were allocated to the trial. All patients received definitive radiation therapy at two German university hospitals between 2009 and 2018. Radiation was delivered as intensity-modulated radiation therapy (IMRT) with 51 Gy to the lymphatic drainage with simultaneous integrated boost (SIB) up to 61.2 Gy to involved nodes and 76.5 Gy to the prostate in 34 fractions. Feasibility and safety, overall and progression-free survival, toxicity, and quality of life measurements were analyzed.

Results
During a median follow-up of 79 months, median overall survival was 107 months and progression-free survival was 78 months. Based on imaging follow-up, no infield relapse was reported during the first 24 months of follow-up. There were 3 (8%) potentially treatment-related grade 3 toxicities. Common iliac node involvement was associated with a higher risk of progression (HR 15.8; 95% CI 2.1–119.8; p = 0.007).

Conclusion
Definitive radiation to the lymphatic drainage with SIB to the involved nodes and prostate is a safe and effective treatment approach for patients with treatment-naïve, node-positive prostate cancer with excellent infield tumor control rates and tolerable toxicity. Location rather than number of involved nodes is a major risk factor for progression.
Influence of demographic change on the demand for radiotherapy using forecasted predictions for prostate cancer in Germany
Authors: Sonnhoff M. , Graff M. , Paal K. , Becker J.-N. , Hermann R.-M. , Christiansen H. , Nitsche M. , Merten R. 
Published: August 2023

Abstract
Purpose
Demographic change will lead to an increase in age-associated cancers. The demand for primary treatment, especially oncologic therapies, is difficult to predict. This work is an attempt to project the demand for radiation therapy (RT) in 2030, taking into account demographic changes using prostate cancer (PC) as an example.

Materials and methods
Using the GENESIS database of the Federal Statistical Office, we retrieved demographic population projections for 2030 and retrospective demographic surveys from 1999 to 2019. Additionally, we queried incidence rates for PC in the respective age groups of 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84, and +85 years from 1999–2019 via the Federal Cancer Registry of the Robert Koch Institute. We used a regression method to determine the age-dependent correlation between the incidence of PC and the population size of the respective age group by combining the data from 1999 to 2019. This information was used to calculate the incidence rates in the age groups of the expected population for 2030 and the expected new cases of PC in 2030. Finally, we extrapolated the indications for the demand for RT based on data from the Report on Cancer Incidence in Germany from 2016.

Results
Considering a population-dependent incidence rate, an increase in new cases of PC is expected. This increase is particularly evident in the age groups of 70–74 and 80–84 years. With regards to RT, the estimate indicates an overall increase of 27.4% in demand. There is also a shift in RT demands towards older patients, especially in the 80- to 84-year-old age group.

Conclusion
We observe an age-associated increase in primary cases of PC. This is likely to result in an increased demand for RT. The exact demand cannot be predicted. However, trends can be estimated to plan for the demand. This, though, requires a good database from cancer registries.