bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Country For ‘Bad’ Men: Volatile Citizenship and the Emerging Features Of Global Neo-colonial Penality
Authors: Tripkovic Milena 
Published: January 2023

Abstract
The article examines instances of de jure and de facto denationalization that arise from (suspected) terrorism by analyzing penal outcomes for affected citizens. The article first exposes cases of de jure denationalization that confine citizens to global spaces and draws parallels with instances of de facto denationalization that deny repatriation from abroad. I then argue that both situations signal state’s avoidance of the duty to punish, deviate from conventional penal aspirations and engender volatile global penality. To support this argument, I explore three questions: (1) who punishes, (2) who is punished and (3) what the purpose of punishment is. I conclude by exposing the emerging features of global neo-colonial penality as they pertain to both its objects and objectives.
CSL324, a granulocyte colony-stimulating factor receptor antagonist, blocks neutrophil migration markers that are upregulated in hidradenitis suppurativa
Authors: Gamell Cristina , Bankovacki Aleksandra , Scalzo-Inguanti Karen , Sedgmen Bradley , Alhamdoosh Monther , Gail Emma , Turkovic Lydia , Millar Christine , Johnson Laura , Wahlsten Michelle , Richter Jim , Schuster Jared , Dyson Allison , Nicolopoulos Jenny , Varigos George , Ng Milica , Wilson Nick , Field Judith , Kern Johannes S , Lindqvist Lisa M 
Published: January 2023

Abstract

Background
Neutrophils have been shown to contribute to the pathophysiology of hidradenitis suppurativa (HS), a chronic, painful and debilitating inflammatory skin disease, yet their exact role remains to be fully defined. Granulocyte colony-stimulating factor (G-CSF), a major regulator of neutrophil development and survival, can be blocked by the novel, fully human anti-G-CSF receptor (G-CSFR) monoclonal antibody CSL324.

Objectives
We investigated the activation and migration of neutrophils in HS and the impact of blocking G-CSFR with CSL324.

Methods
Biopsy and peripheral blood samples were taken from participants of two studies: 2018.206, a noninterventional research study of systemic and dermal neutrophils and inflammatory markers in patients with neutrophilic skin diseases, and CSL324_1001 (ACTRN12616000846426), a single-dose ascending and repeated dose, randomized, double-blind, placebo-controlled study to assess the safety, pharmacokinetics and pharmacodynamics of CSL324 in healthy adult subjects. Ex vivo experiments were performed, including neutrophil enumeration and immunophenotyping, migration, receptor occupancy and transcriptome analysis.

Results
The number of cells positive for the neutrophil markers myeloperoxidase (MPO) and neutrophil elastase (NE) was significantly higher in HS lesions compared with biopsies from healthy donors (HDs) (P &lt; 0.0001 and P = 0.0223, respectively). In peripheral blood samples, mean neutrophil counts were significantly higher in patients with HS than in HDs (2.98 vs. 1.60 × 109 L–1, respectively; P = 8.8 × 10–4). Neutrophil migration pathways in peripheral blood were increased in patients with HS and their neutrophils demonstrated an increased migration phenotype, with higher mean CXCR1 on the surface of neutrophils in patients with HS (24453.20 vs. 20798.47 for HD; P = 0.03). G-CSF was a key driver of the transcriptomic changes in the peripheral blood of patients with HS and was elevated in serum from patients with HS compared with HDs (mean 6.61 vs. 3.84 pg mL–1, respectively; P = 0.013). Administration of CSL324 inhibited G-CSF-induced transcriptional changes in HDs, similar to those observed in the HS cohort, as highlighted by expression changes in genes related to neutrophil migratory capacity.

Conclusions
Data suggest that neutrophils contribute to HS pathophysiology and that neutrophils are increased in lesions due to an increase in G-CSF-driven migration. CSL324 counteracted G-CSF-induced transcriptomic changes and blocked neutrophil migration by reducing cell-surface levels of chemokine receptors.
Miliaria crystallina
Authors: Palaniappan Vijayasankar , Sadhasivamohan Anusuya , Sankarapandian Jeyalakshmi , Karthikeyan Kaliaperumal 
Published: January 2023

Abstract
Miliaria crystallina (MC) is an uncommon form of a sweat retention syndrome that chiefly affects neonates. It is more common in hot and humid conditions, such as in tropical regions. It commonly presents as clusters of dewdrop-like vesicles on a nonerythematous base that heals with furfuraceous scaling. A clinical diagnosis is often sufficient. The differential diagnosis is wide and varying. One of the hallmarks of MC is its self-limiting nature. The purpose of this review is to increase awareness of this condition among physicians and dermatologists.
Identifying the core microbiome of the sea starPisaster ochraceusin the context of sea star wasting disease
Authors: Loudon Andrew H , Park Jungsoo , Parfrey Laura Wegener 
Published: January 2023

AbstractSea stars are keystone species and their mass die-offs due to sea star wasting disease (SSWD) impact marine communities and have fueled recent interest in the microbiome of sea stars. We assessed the host specificity of the microbiome associated with three body regions of the sea star Pisaster ochraceus using 16S rRNA gene amplicon surveys of the bacterial communities living on and in Pisaster, their environment, and sympatric marine hosts across three populations in British Columbia, Canada. Overall, the bacterial communities on Pisaster are distinct from their environment and differ by both body region and geography. We identified core bacteria specifically associated with Pisaster across populations and nearly absent in other hosts and the environment. We then investigated the distribution of these core bacteria on SSWD-affected Pisaster from one BC site and by reanalyzing a study of SSWD on Pisaster from California. We find no differences in the distribution of core bacteria in early disease at either site and two core taxa differ in relative abundance in advanced disease in California. Using phylogenetic analyses, we find that most core bacteria have close relatives on other sea stars and marine animals, suggesting these clades have evolutionary adaptions to an animal-associated lifestyle.
Which actors drove national patterns of technological specialization into the science-based age? The British experience, 1918–1932
Authors: Cantwell John , Spadavecchia Anna 
Published: January 2023

AbstractThis article assesses the contributions of industry leaders, smaller corporations, and independent inventors to the international technological specialization of Great Britain in the interwar years. For the first time, we compare directly the contribution of these sources and combine the Chandlerian and “sources of invention” perspectives. The analysis is based on a novel dataset of more than 8,000 patents granted in the USA to British inventions. Our findings show the extent to which Britain integrated inventions generated by independent inventors with those of corporate inventors, i.e., industry leaders and smaller corporations, in both engineering- and science-based fields. This research highlights specificities of a former leader’s transition from the technological paradigm of the first phase of capitalism to that of the second phase.
A review of the application of active learning pedagogies in undergraduate animal science curricula
Authors: Ragland Elizabeth C , Radcliffe Scott , Karcher Elizabeth L 
Published: January 2023

Abstract
With most of the student attrition occurring early in undergraduate educational programs (Braunstein et al., 1997) it is necessary to interest and motivate students early on. The demographics of animal science students have shifted to students with minimal background in food producing animals. This presents a unique challenge as the current student population represents a diverse array of backgrounds and prior experiences. As a result, students enroll in undergraduate animal science programs with various expectations for their undergraduate degree and a focus primarily on careers in veterinary medicine. To engage all students, interest and motivation need to be generated. This review will use motivational frameworks as outlined by the self-determination theory, expectancy value theory, and interest, to explain the impact of the proposed solutions. Active learning classroom strategies are linked to increased knowledge compared with traditional, passive classrooms (Wells et al., 2019). Active learning shifts from a traditional teaching model to a student-centered model, which transitions instructors to facilitators of learning. This review summarizes current proposed pedagogies that have been researched in animal science classrooms such as experiential learning, flipped classrooms, hands-on animal experience, undergraduate research experiences, mentorship opportunities, capstone experiences, service-learning experiences, team-based learning, and cooperative learning. The limitations of these proposed pedagogies and the future research needed are also discussed.
Management of heart failure in patients with kidney disease—updates from the 2021 ESC guidelines
Authors: Edwards Nicola C , Price Anna M , Steeds Richard P , Ferro Charles J , Townend Jonathan N 
Published: January 2023

ABSTRACT
The wide overlap between the syndromes of chronic kidney disease (CKD) and chronic heart failure (HF) means that familiarity with the 2021 European Society of Cardiology guidelines is of importance to nephrologists. The common risk factors for the two syndromes together with the adverse cardiac structural remodelling associated with CKD means that many kidney disease patients experience breathlessness and fall within the HF phenotypes categorized in the guidelines. The management of HF is evolving rapidly leading to significant changes in the latest guideline iteration. The 2021 guidelines have changed from the 2016 version firstly by an increased focus on identifying the three phenotypes of HF to guide appropriate evidence-based management. Secondly, a new and simplified treatment algorithm for HF with reduced ejection fraction involving the rapid sequential initiation and up-titration of four ‘pillars’ of drug treatment—angiotensin-converting enzyme inhibitors or angiotensin-neprilysin inhibitors, beta blockers, mineralocorticoid receptor antagonists and now, thanks to convincing trial data, sodium-glucose co-transporter 2 inhibitors. Thirdly, guidelines for device therapy have been changed with down-graded advice on indications for primary prevention implantable cardioverter defibrillator therapy for patients with non-ischaemic HF and for cardiac resynchronization therapy with left bundle branch block (LBBB) and a QRS duration &lt;150 ms. There are updated treatment plans for HF associated with non-cardiovascular comorbidities including CKD.
Long-term outcomes of COVID-19 survivors with hospital AKI: association with time to recovery from AKI
Authors: Lu Justin Y , Boparai Montek S , Shi Caroline , Henninger Erin M , Rangareddy Mahendranath , Veeraraghavan Sudhakar , Mirhaji Parsa , Fisher Molly C , Duong Tim Q 
Published: January 2023

ABSTRACT

Background
Although coronavirus disease 2019 (COVID-19) patients who develop in-hospital acute kidney injury (AKI) have worse short-term outcomes, their long-term outcomes have not been fully characterized. We investigated 90-day and 1-year outcomes after hospital AKI grouped by time to recovery from AKI.

Methods
This study consisted of 3296 COVID-19 patients with hospital AKI stratified by early recovery (&lt;48 hours), delayed recovery (2–7 days) and prolonged recovery (&gt;7–90 days). Demographics, comorbidities and laboratory values were obtained at admission and up to the 1-year follow-up. The incidence of major adverse cardiovascular events (MACE) and major adverse kidney events (MAKE), rehospitalization, recurrent AKI and new-onset chronic kidney disease (CKD) were obtained 90-days after COVID-19 discharge.

Results
The incidence of hospital AKI was 28.6%. Of the COVID-19 patients with AKI, 58.0% experienced early recovery, 14.8% delayed recovery and 27.1% prolonged recovery. Patients with a longer AKI recovery time had a higher prevalence of CKD (P &lt; .05) and were more likely to need invasive mechanical ventilation (P &lt; .001) and to die (P &lt; .001). Many COVID-19 patients developed MAKE, recurrent AKI and new-onset CKD within 90 days, and these incidences were higher in the prolonged recovery group (P &lt; .05). The incidence of MACE peaked 20–40 days postdischarge, whereas MAKE peaked 80–90 days postdischarge. Logistic regression models predicted 90-day MACE and MAKE with 82.4 ± 1.6% and 79.6 ± 2.3% accuracy, respectively.

Conclusion
COVID-19 survivors who developed hospital AKI are at high risk for adverse cardiovascular and kidney outcomes, especially those with longer AKI recovery times and those with a history of CKD. These patients may require long-term follow-up for cardiac and kidney complications.
A Method to Amend Cigarettes With Menthol for Use in Research
Authors: Jackson Kia J , Schroeder Megan J , Ai Jiu , Taylor Kenneth M , Oniyide Olusola , Viray Lauren C , Smith Carson , Koszowski Bartosz , Butler Jenny M , Pickworth Wallace B 
Published: January 2023

AbstractIntroductionStudies have evaluated the role of menthol cigarettes on various addiction-related outcomes; however, the effect of varying menthol content on these outcomes has not been evaluated. We developed a method to amend non-menthol SPECTRUM Research Cigarettes to contain menthol at four different levels.Aims and MethodsSPECTRUM Research Cigarettes, NRC 600 (0.8 mg nicotine; 10 mg tar), were modified to contain target menthol amounts at 3, 6, and 12 mg/cigarette by injecting 25 µL ethanol/triacetin/menthol solutions of varying concentrations (120 mg menthol/mL, 240 mg/mL, and 480 mg/mL) into four distinct locations in the filter and tobacco rod. Menthol content was tested in triplicate in the whole cigarette and in the tobacco rod and filter at 1, 24, 48, and 72 hours for each target menthol level using an extraction solution of quinoline in methyl-tert-butyl ether and measured using gas chromatography with flame ionization detection.ResultsInjections into the filter and tobacco rod (12.5 µL each) yielded equal menthol distribution up to 72 hours. However, total menthol content decreased from an average of 90.3% of the target menthol concentration at 1 hour to 80.7% at 72 hours in cigarettes stored individually in glass tubes at room temperature. Analysis of urinary menthol glucuronide confirmed that amended cigarettes used within 24 hours of injection delivered dose-related menthol levels to participants in a clinical laboratory setting.ConclusionThis method can be used to modify cigarettes with a range of reliable menthol levels in both filter and tobacco rod for use in laboratory and clinical research.ImplicationsThis study presents a technique for modifying cigarettes with different levels of menthol that can reliably deliver dose-related menthol levels to participants when smoked in a clinical study. The technique can be used to quickly amend cigarettes to examine the independent effects of varying flavor and additive levels on smoking behavior, nicotine pharmacokinetics, mainstream smoke emissions, and other laboratory or clinical research outcomes.
Exotic smooth structures on connected sums of S2×S2
Authors: Akhmedov Anar , Park B Doug , Sakallı Sümeyra 
Published: January 2023

Abstract
We construct infinitely many distinct irreducible smooth structures on $n(S^2\,\times\,S^2)$, the connected sum of n copies of $S^2\,\times\,S^2$, for every odd integer $n\geq 27$.
John Marston’s Stationers, 1607–1633
Authors: Cathcart Charles 
Published: January 2023

Abstract
This essay revisits the publication of John Marston’s writings following his withdrawal from theatrical activity. It directs attention away from Marston’s presumed interventions and examines the choices and activities of five stationers: Thomas Thorpe, Thomas Archer, Richard Hawkins, Hugh Perry, and William Sheares. Their release of Marston’s writing offers a sharp insight into their various strategies and practices. Thorpe’s handling of What You Will and Histrio-mastix is best understood in relation to his choice to publish the plays of Marston, Jonson, and Chapman—and those of no other dramatist. Archer’s release of The Insatiate Countesse makes most sense in relation to the Overbury scandal. Hawkins—unlike his peers—progressively accentuated authorial agency in the successive editions of The Metamorphosis of Pigmalions Image within his series of Alcilia-led compilations. Perry and Sheares seem to have been running a joint enterprise at the time of The Workes of Mr John Marston of 1633. By turning towards the choices made by these stationers and placing less emphasis on the hypothesis of Marston’s reluctance to be associated with his writings, a new history of reception, dissemination, and publishing enterprise emerges.
The Leading Premium
Authors: Croce Mariano M , Marchuk Tatyana , Schlag Christian 
Published: January 2023

Abstract
In this paper, we consider conditional measures of lead-lag relations between aggregate growth and industry-level cash flow growth in the United States. Our results show that firms in leading industries pay an average annualized return 3.6$\%$ higher than that of firms in lagging industries. Using both time-series and cross-sectional tests, we estimate an annual pure timing premium ranging from 1.2$\%$ to 1.7$\%$. This finding can be rationalized in a model in which (a) agents price growth news shocks, and (b) leading industries provide valuable resolution of uncertainty about the growth prospects of lagging industries.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Remote Assessment of Negative Symptoms of Schizophrenia
Authors: Daniel David G , Cohen Alex S , Velligan Dawn , Harvey Phillip D , Alphs Larry , Davidson Michael , Potter William , Kott Alan , Schooler Nina , Brodie Christopher R , Moore Raeanne C , Lindenmeyer Pierre , Marder Stephen R 
Published: January 2023

AbstractIn contrast to the validated scales for face-to-face assessment of negative symptoms, no widely accepted tools currently exist for remote monitoring of negative symptoms. Remote assessment of negative symptoms can be broadly divided into 3 categories: (1) remote administration of an existing negative-symptom scale by a clinician, in real time, using videoconference technology to communicate with the patient; (2) direct inference of negative symptoms through detection and analysis of the patient’s voice, appearance, or activity by way of the patient’s smartphone or other device; and (3) ecological momentary assessment, in which the patient self-reports their condition upon receipt of periodic prompts from a smartphone or other device during their daily routine. These modalities vary in cost, technological complexity, and applicability to the different negative-symptom domains. Each modality has unique strengths, weaknesses, and issues with validation. As a result, an optimal solution may be more likely to employ several techniques than to use a single tool. For remote assessment of negative symptoms to be adopted as primary or secondary endpoints in regulated clinical trials, appropriate psychometric standards will need to be met. Standards for substituting 1 set of measures for another, as well as what constitutes a “gold” reference standard, will need to be precisely defined and a process for defining them developed. Despite over 4 decades of progress toward this goal, significant work remains to be done before clinical trials addressing negative symptoms can utilize remotely assessed secondary or primary outcome measures.
Early treatment with terlipressin in patients with hepatorenal syndrome yields improved clinical outcomes in North American studies
Authors: Curry Michael P. , Vargas Hugo E. , Befeler Alex S. , Pyrsopoulos Nikolaos T. , Patwardhan Vilas R. , Jamil Khurram 
Published: January 2023

Hepatorenal syndrome type 1 (HRS-1) is a serious complication of advanced cirrhosis and a potentially reversible form of acute kidney injury that is associated with rapidly deteriorating kidney function. Liver transplantation remains the only curative treatment for decompensated cirrhosis. However, terlipressin, a vasopressin analog, successfully reverses HRS-1, and may improve patient survival while awaiting liver transplantation. Patients with higher baseline serum creatinine have a reduced response to treatment with terlipressin. These post hoc analyses examined pooled data from 352 patients with HRS-1 treated with terlipressin in 3 North American-centric, Phase III, placebo-controlled clinical studies (i.e. OT-0401, REVERSE, and CONFIRM)—across 3 serum creatinine subgroups (i.e. <3, ≥3–<5, and ≥5 mg/dL)—to further delineate their correlation with HRS reversal, renal replacement therapy-free survival, and overall survival. Serum creatinine was significantly associated with HRS reversal in univariate and multivariate logistic regression analyses (P<0.001). The incidence of HRS reversal inversely correlated with serum creatinine subgroup (<3 mg/dL, 49.2%; ≥3–<5 mg/dL, 28.0%; ≥5 mg/dL, 9.1%). At Day 30 follow-up, renal replacement therapy-free survival was significantly higher for patients with HRS-1 in the lower serum creatinine subgroups than in the higher subgroup (<5 vs. >5 mg/dL; p=0.01). Terlipressin-treated patients with HRS-1, with a lower baseline serum creatinine level, had a higher overall survival (p<0.001) and higher transplant-free survival at Day 90 (p=0.04). Patients with HRS-1 and lower serum creatinine levels who were treated with terlipressin had higher HRS reversal and survival outcomes, highlighting the significant need to identify and treat patients with HRS-1 early when they often have lower serum creatinine levels, and likely a greater response to terlipressin.
Training Tomorrow’s Physicians in Value Conscious Medicine
Authors: Makhoul Alexandra E. , Kertai Miklos D. , Powers James , Dahlman Kimberly B. , Suojanen Krista 
Published: January 2023

Problem
Future physicians will practice medicine in an increasingly complex health care system. To become effective leaders of value-based teams and to practice cost-conscious care, medical students need training in and exposure to value conscious medicine (VCM).

Approach
A student-led initiative to enhance education in VCM led to the development of the 4-week elective course (High Value Care: In Policy and in Practice) for postclerkship third- and fourth-year students, introduced in 2021 at Vanderbilt University School of Medicine. The course included structured didactics, self-directed online modules, a book club, and flipped-classroom discussions in addition to clinical rotations focused on VCM in practice.

Outcomes
Students’ self-ratings of their understanding of VCM, preparation to practice value-based care, and comfort incorporating patient and system costs into clinical decisions improved after completing the course. Most indicated they would recommend the course to their peers. Suggestions for improvement included more teach-back sessions with faculty as well as more direction for preceptors to demonstrate specific aspects of VCM.

Next Steps
The authors share this example of a dedicated medical school VCM course as a step toward achieving the vision of integrating value into clinical decision making and empowering students to become informed and capable future physicians. Other institutions may consider adapting this course example to prepare their students to practice VCM in an increasingly cost-focused system.