bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrahepatic cholestasis of pregnancy and neonatal outcomes in assisted reproductive technology versus spontaneous conception: a prediction nomogram-based study
Authors: Yang Jingwei , Gao Jing , Zhou Danni , Luo Qian , Ye Hong , Huang Guoning , Lian Xuemei , Zhang Xiaodong 
Published: April 2023

Abstract
Background
There are a limited number of studies comparing intrahepatic cholestasis of pregnancy (ICP) and neonatal outcomes in puerperae who spontaneously conceived (SC) and those who conceived via in vitro fertilization (IVF). We aimed to investigate the incidence of intrahepatic cholestasis of pregnancy (ICP) as well as neonatal outcomes between conception via IVF compared with spontaneous conception and screen the risk factors of ICP in IVF.
Methods
A retrospective cohort study included 4,467 puerperae who conceived via IVF, and 28,336 puerperae who conceived spontaneously and linked the information from neonates. Cochran–Mantel–Haenszel (CMH) analysis and a general linear model (GLM) were used to control bias. We compared the related serum-derived indicators and neonatal outcomes of ICP patients with IVF and SC. Multivariate logistic regression analysis, a forest plot, and nomogram were used to assess impact factors and risk prediction.
Results
Logistic analysis adjusted for confounders revealed significant differences in the ICP rate of singleton delivery (4.24% vs. 3.41%, adjusted OR = 1.26 [95% confidence interval (CI) 1.03–1.53], P = 0.025) and in groups with total bile acids(TBA) ≥ 40 and < 100 µmol/L (14.77% vs. 10.39%, aOR = 1.31[95% CI 1.06–1.63], P = 0.023) between IVF and SC. When we divided newborns into singleton and twins delivery, the GLM revealed a higher rate with Apgar score < 7 (13.44% vs. 3.87%; aOR = 3.85 [95% CI: 2.07–7.17], P < 0.001) and fetal distress for IVF in comparison with SC (19.32% vs. 5.55%; OR = 3.48 [95%CI: 2.39–6.95], P < 0.001) in the singleton group. In multivariate logistic regression analysis, body mass index (BMI) (aOR = 1.29, P = 0.031), number of embryo transferred (ET) (single ET vs. double ET: aOR = 2.82, P < 0.001), E2 level on the ET day (aOR = 2.79, P = 0.011), fresh ET which compared with frozen ET (FET) (aOR = 1.45, P = 0.014), embryo stage(cleavage embryo vs. Blastocyst, aOR = 1.75, P = 0.009) and severe ovarian hyperstimulation syndrome (OHSS) which compared with non-OHSS (aOR = 3.73, P = 0.006) were independent predictors of ICP. And these predictive factors in the logistic regression model were integrated into the nomogram (C-index = 0.735 [95% CI, 0.702–0.764]); for each patient, higher total points indicated a higher risk of ICP.
Conclusion
We observed that the ICP rate of singleton delivery was higher in IVF than in SC. In ICP patients, there were higher rates of neonatal Apgar score < 7 and fetal distress in IVF than SC, and found the predictors of ICP in IVF.
Gibberellic acid signaling promotes resistance to saline–alkaline stress by increasing the uptake of ammonium in rice
Authors: Li Zhuo , Chen Huan , Guan Qingjie , Li Lixin , Xuan Yuanhu 
Published: April 2023

Abstract
Gibberellic acid (GA) plays important roles in diverse biological processes in plants. However, its function in the resistance of rice (Oryza sativa) to saline-alkaline (SAK) stress is unclear. In this study, we found that SAK stimuli changed the levels of expression of the GA signaling genes. Genetic analyses using the mutants of key GA signaling regulators Slender rice 1 (SLR1) and Dwarf 1(D1) demonstrated that SLR1 negatively regulated the resistance of rice to SAK stress, while D1 positively regulated it, suggesting the GA signaling positively regulates the resistance of rice to SAK. A previous study showed that SLR1 interacts with Phytochrome interacting factor-like 14 (PIL14) to regulate the resistance of rice to salt stress. However, PIL14 overexpressor (OX) plants exhibited a similar response to SAK as the wild-type (WT) controls. Further analyses revealed that SLR1 interacted with and inhibited the activation of transcription of IDD10 and bZIP23. Furthermore, IDD10 interacted with bZIP23 to activate Ammonium transporter 1;2 (AMT1;2), and slr1, IDD10 OX and bZIP23 OX accumulated more ammonium (NH4+) than the WT plants. In addition, the bzip23 T-DNA mutant was more sensitive to SAK, while bZIP23 OX was less sensitive compared with the WT. This suggested that bZIP23 is similar to IDD10, which positively regulates the resistance of rice to SAK. Taken together, this data proved that GA signaling promotes the resistance of rice to SAK by modulating the uptake of NH4+ in rice mediated by SLR1-IDD10-bZIP23.
Assessment of Women's Awareness of Reproductive Health Concepts in Iraqi Community
Authors: Zubair Omaima Abdulrazzaq 
Published: April 2023

Abstract
Background
Reproductive and sexual health knowledge is a major health indicator in communities. Underestimation of awareness of its determinants will affect the welfare of people and retreat community progress. The present study aims to assess women’s awareness of reproductive health in the Iraqi community.
Methods
To collect the information from the participants, the researcher has adopted a cross-sectional study design with questionnaire form has distributed among all Iraqi governorates via Google form through social media and direct interviews. A convenient sample of 3416 women was included in the study.
Results
Only a third of the participants have adequate awareness regarding premarital care, child marriage, and breastfeeding. Sexually transmitted disease and contraceptive methods awareness were represented by only 20%, and 10% of the participants, respectively. Relativity of marriage was prevalent in 26% of married participants. Vaccination and vitamin supplementation, and a healthy diet had better representation of adequate knowledge 44%,41%, and 55%, respectively; in opposite to sports knowledge who represents just (8%) of them. About half of the participants have adequate knowledge concerning the effect of stress on health but little knowledge about healthy sleeping patterns (27%). health facilities usage awareness was 5% with private facilities visits occupying the most predominant visit site.
Conclusion
The study revealed a minimal level of awareness about reproductive health among participants women and girls in the Iraqi. An education programs should be directed to all Iraqi strata to raise their level of awareness about this subject
Prevalence and Associated Factors of Toenail Onychomycosis Among
Patients with Diabetes in Jordan
Authors: Alrauosh Hesham , Ababneh Anas , Bakri Faris G. , Abujbara Mousa , Kanaan Hashem , Younes Nidal A. 
Published: April 2023

Background:
Toenail onychomycosis is common in patients with diabetes and it can increase
the risk of secondary infections and foot complications. Despite several studies investigating
the prevalence and associated factors of toenail onychomycosis from different parts of the world,
there are no data from Jordan.

Objective:
To determine the prevalence and the associated factors of toenail onychomycosis among
patients with diabetes in Jordan.

Methods:
A cross-sectional study was conducted on 375 patients with diabetes at the National
Centre for Diabetes, Endocrinology, and Genetics in Amman, Jordan. Several socio-demographic
and health-independent variables including foot self-care practices were collected. Toenail onychomycosis
was assessed by a specimen culture and microscopic examinations. Descriptive and
inferential statistics were used for data analysis.

Results:
The prevalence of toenail onychomycosis was 57.6% (n=216). Multiple logistic regression
revealed four significant associated factors; the presence of neuropathy (β=1.87, p=0.02), being
an ex-smoker (β=2.69, p=0.01), being treated by both insulin and oral hypoglycemics drugs
(β=1.32, p=0.03), and using antibiotics in the last year (β=1.78, p=0.02).

Conclusion:
The prevalence of toenail onychomycosis among patients with diabetes in Jordan is
high. Regular foot screening and podiatric care are recommended especially among patients with
diabetic neuropathy, current treatment by insulin and oral hypoglycemics drugs, previous history of
smoking, and previous use of antibiotics.
The Effectiveness of Online-Only Blended Cardiopulmonary Resuscitation Training: Static-Group Comparison Study
Authors: Chong Kah Meng , Yang Hsiang-Wen , He Hsien-Chin , Lien Wan-Ching , Yang Mei-Fen , Chi Chien-Yu , Chen Yen-Pin , Huang Chien-Hua , Ko Patrick Chow-In 
Published: April 2023

Background
Basic life support (BLS) education is essential for improving bystander cardiopulmonary resuscitation (CPR) rates, but the imparting of such education faces obstacles during the outbreak of emerging infectious diseases, such as COVID-19. When face-to-face teaching is limited, distance learning—blended learning (BL) or an online-only model—is encouraged. However, evidence regarding the effect of online-only CPR training is scarce, and comparative studies on classroom-based BL (CBL) are lacking. While other strategies have recommended self-directed learning and deliberate practice to enhance CPR education, no previous studies have incorporated all of these instructional methods into a BLS course.

Objective
This study aimed to demonstrate a novel BLS training model—remote practice BL (RBL)—and compare its educational outcomes with those of the conventional CBL model.

Methods
A static-group comparison study was conducted. It included RBL and CBL courses that shared the same paradigm, comprising online lectures, a deliberate practice session with Little Anne quality CPR (QCPR) manikin feedback, and a final assessment session. In the main intervention, the RBL group was required to perform distant self-directed deliberate practice and complete the final assessment via an online video conference. Manikin-rated CPR scores were measured as the primary outcome; the number of retakes of the final examination was the secondary outcome.

Results
A total of 52 and 104 participants from the RBL and CBL groups, respectively, were eligible for data analysis. A comparison of the 2 groups revealed that there were more women in the RBL group than the CBL group (36/52, 69.2% vs 51/104, 49%, respectively; P=.02). After adjustment, there were no significant differences in scores for QCPR release (96.9 vs 96.4, respectively; P=.61), QCPR depth (99.2 vs 99.5, respectively; P=.27), or QCPR rate (94.9 vs 95.5, respectively; P=.83). The RBL group spent more days practicing before the final assessment (12.4 vs 8.9 days, respectively; P<.001) and also had a higher number of retakes (1.4 vs 1.1 times, respectively; P<.001).

Conclusions
We developed a remote practice BL–based method for online-only distant BLS CPR training. In terms of CPR performance, using remote self-directed deliberate practice was not inferior to the conventional classroom-based instructor-led method, although it tended to take more time to achieve the same effect.

Trial Registration
Not applicable.
ANALISIS PENDAPATAN DAN KELAYAKAN USAHATANI CENGKEH DI DESA SILAMPAYANG KECAMATAN KASIMBAR KABUPATEN PARIGI MOUTONG
Authors: Marzuki Nur Fadillah , Effendy Effendy , Hatmi Wira 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pendapatan dan kelayakan usahatani cengkeh di Desa Silampayang Kecamatan Kasimbar Kabupaten Parigi Moutong. Penelitian ini dilaksanakan pada bulan Maret sampai dengan Mei 2022. Responden pada penelitian ini sebanyak 30 dengan jumlah populasi petani cengkeh
sebanyak 90 orang. Pada penelitian ini menunjukkan bahwa penerimaan petani cengkeh rata-rata sebesar Rp. 31.566.131/Ha/Tahun, rata-rata total biaya adalah Rp. 11.967.787/Ha/Tahun, maka rata-rata pendapatan petani cengkeh adalah Rp. 19.598.344/Ha/Tahun. Pada kelayakan usahatani cengkeh adalah R/C = 2,63
artinya usahatani cengkeh tersebut layak diusahakan oleh petani, mengingat R/C Ratio lebih besar dari 1, dimana nilai tersebut menunjukkan total penerimaan lebih besar dari total biaya-biaya yang dikeluarkan oleh petani cengkeh di Desa Silampayang Kecamatan Kasimbar Kabupaten Parigi Moutong.
ANALISIS PENENTUAN HARGA POKOK PRODUKSI PADA INDUSTRI TAHU KAROMA DI KOTA PALU
Authors: Julianto Wayan Nova , Antara Made , Wibawa I Gede Laksana 
Published: April 2023

Tujuan penelitian ini yaitu ingin mengetahui berapa harga pokok produksi menggunakan metode full costing dan variable costing pada industri tahu karoma di kota palu. Penelitian ini dilaksanakan di industri Tahu Karomah yang terletak di Kota Palu pada bulan Juli 2022.Penentuan Responden dilakukan secara sengaja (Purposive), dengan jumlah responden sebanyak 3 (tiga) orang yakni, pimpinan industri dan dua orang karyawan bagian produksi Industri Tahu Karoma. Penelitian ini menggunakan data primer dan data sekunder, sedangkan alat analisis yang digunakan adalah analisis penentuan harga pokok produksi
menggunakan metode full costing dan variable costing. Hasil penelitian ini menunjukan harga pokok produksi menurut perusahan Industri Tahu Karoma sebesar Rp93.000.000,- dengan harga pokok pokok per satuanRp3.800,- dan harga pokok produksi dengan metode full costingsebesar Rp96.076.850,- dengan harga pokok produksi per kg sebesar Rp3.912,-/kg. Sedangkan harga pokok produksi dengan metode variable costing sebesar Rp87.906.000,- dan Harga pokok Produksi per Kg sebesar Rp3.588,-/kg. selisih harga pokok produksi dengan menggunakan metode full costing dan menurut perusahan sebesar Rp. 3.076.450,- dengan selisih harga pokok produksi per satuan sebesar Rp 121/Kg,-. Selisih penghitungan pokok produksi menurut perusahaan dan menurut metode variable costing untuk produksi tahu di Industri Tahu Karoma yaitu sebesar Rp 5.094.000,- dengan selisih harga pokok produksi per satuan yaitu sebesar Rp 212/kg,-.
STRATEGI PENGEMBANGAN DURIAN MONTONG KUPAS PADA INDUSTRI SILVIA JAYA DI DESA TOLAI KECAMATAN TORUE
Authors: Ganata I Gede Giri , Asih Dewi Nur , Hatmi Wira 
Published: April 2023

Penelitian ini bertujuan mengetahui strategi pengembangan durian montong kupas pada industri Silvia Jaya di Desa Tolai Kecamatan Torue. Penelitian dilaksanakan di industri Silvia Jaya pada bulan Mei-Agustus 2022, penentuan responden dilakukan secara sengaja (Purposive), dengan jumlah responden sebanyak 9 orang yaitu pimpinan industri, 3 orang karyawan tetap, 2 orang pesaing industri, 2 orang konsumen akhir dan 1 orang penyedia modal. Analisis yang digunakan adalah
analisis SWOT. Hasil penelitian menunjukan berdasarkan hasil perhitungan IFAS didapatkan hasil kondisi internal CV. Silvia Jaya diperoleh hasil pengurangan dari total skor faktor kekuatan dan total skor faktor kelemahan sebagai sumbu X yaitu sebesar 1,10, sedangkan pada hasil perhitungan EFAS didapatkan hasil kondisi eksternal CV. Silvia Jaya diperoleh hasil pengurangan dari total skor faktor peluang dan total skor faktor acaman sebagai sumbu Y yaitu sebesar 1,26. Alternatif strategi yang dapat diterapkan dalam Strategi Pengembangan Durian Montong Kupas Pada Industri Silvia Jaya di Desa Tolai Kecamatan Torue adalah strategi S-O. 1. Memanfaatkan pengalaman ber-usaha dalam mengelola usaha untuk memperoleh harga jual yang mahal. 2. Memanfaatkan kualitas produk danproduk tanpa pengawet untuk merebut pasar seluas-luasnya. 3. Memanfaatkan permintaan tinggi dan memanfaatkan berkembangnya media promosi guna memperoleh konsumen baru.
Plasma insulin concentration in newborns and children and age at menarche
Authors: Wang Guoying , Radovick Sally , Buckley Jessie P. , Hauser Russ , Williams Paige L. , Hong Xiumei , PEARSON COLLEEN , Adams William G. , Wang Xiaobin 
Published: April 2023

<p> </p>
<p><em><strong>OBJECTIVE</strong></em><strong>:</strong> To investigate the association of plasma insulin levels and their trajectories from birth to childhood with the timing of menarche. </p>
<p><em><strong>RESEARCH DESIGN AND METHODS</strong></em><strong>: </strong>This prospective study included 458 girls recruited at birth between 1998 and 2011 and followed prospectively at the Boston Medical Center. Plasma non-fasting insulin concentrations were measured at two time points: at birth (cord blood) and in childhood (age 0.5-5 years). Age at menarche was obtained from a pubertal developmental questionnaire or abstracted from electronic medical records. </p>
<p><em><strong>RESULTS</strong></em><strong>: </strong>306 (67%) of the girls had reached menarche. The median (range) age at menarche was 12.4 (9-15) years. Elevated plasma insulin concentrations at birth (n=391) and in childhood (n=335) were each associated with an earlier mean age at menarche: approximately 2 months earlier per doubling of insulin concentration (mean shift, -1.95 months, 95%CI, -0.33 to -3.53 and -2.07 months, 95%CI, -0.48 to -3.65), respectively. Girls with overweight or obesity in addition to elevated insulin attained menarche about 11-17 months earlier on average than those with normal weight and low insulin. Considering longitudinal trajectories (n=268), having high insulin levels at both birth and childhood was associated with a roughly 6 months earlier mean age at menarche (mean shift, -6.25 months, 95%CI, -0.38 to -11.88), compared with having consistently low insulin levels at both timepoints. </p>
<p><em><strong>CONCLUSIONS</strong></em><strong>:</strong> Our data showed that elevated insulin concentrations in early life, especially in conjunction with overweight or obesity, contribute to the earlier onset of menarche, suggesting the need for early screening and intervention. </p>
Studija Ekonomske Opravdanosti Ulaganja U Inženjersko Naselje (Bungalove) U Vlasništvu Zp “Hidroelektrane Na Drini” A.D. Višegrad
Authors: Mastilo Zoran , Subotić Slobodan , Puška Adis , Miletić Vesna , Mastilo Dejan , Šimšić Vladimir 
Published: April 2023

Abstract
Ova Studija nastaje u vremenu potrebe za rekonstrukcijom, adaptacijom, popravkom i unapređenjem inženjerskog naselja (Bungalovi) Mješovitog Holdinga “ERS” MP a.d. Trebinje ZP “ Hidroelektrane na Drini” a.d. Višegrad, u naselje koje će biti na mapi turističke ponude Višegrada. Turizam Višegrada je u ekspanziji, raste tražnja za turističkom ponudom. Geografski položaj Višegrada, ćuprija na Drini koja je vezana za nobelovca Ivu Andrića, zatim od nedavno Andrićgrad, kao i blizina Zlatibora, doprinose da Višegrad bude veoma interesantna turistička destinacija. Cilj inoviranog naselja jeste profit, koji će ovo preduzeće ostvarivati putem izdavanja bungalova zainteresovanim turistima. Mješoviti Holding “ERS” MP a.d. Trebinje ZP “ Hidroelektrane na Drini”, a.d. Višegrad, uradilo je sve pripreme za adaptaciju istog, tj. naselje se priprema za turističku ponudu. Godina 2023. jeste godina kada se očekuju intezivni radovi na ovom projektu, odnosno godina završetka najvećeg dijela radova. Finansijska sredstva za rekonstrukciju i adaptaciju istih,od strane nadležnih organa ovog preduzeća, odobrena su planom nabavki za 2023. godinu. Ekonomsko finansijska analiza i istraživanje tržišta, kao sastavni dijelovi ove Studije, pokazuju da je racionalno i ekonomski opravdano ulaganje u rekonstrukciju, adaptaciju i popravku bungalova, s ciljem da postanu sastavni dio turističke ponude Višegrada. Na osnovu Studije može se zaključiti da bi bilo neopravdano da naselje služi samo za izdavanje, znajući da je većina gostiju zainteresovana za usluge SPA centra. Zato ova Studija predviđa izgradnju i SPA centra, sa korištenjem termalne vode koja se nalazi u neposrednoj blizini, što zasigurno može biti komparativna prednost ovog naselja.
Political Communication and Deliberative Democracy
Authors: Čabraja Toni 
Published: April 2023

Abstract
The problem of political abstention of voters leaves democratic institutions without content. That is why the role of political communication in the context of the essential development of democracy is becoming very relevant today. We are interested in how deliberative communication, as a model of political communication, is connected with the mobilization of voters in political processes, which is how democracy is realized. The meaning of deliberatization is based on the idea of bringing stakeholders closer to a consensus through a free and equal dialogue of political communication in the communication community. In this way, a better legitimacy of political decisions is achieved. It is a process of discursive political communication that "creates and maintains" the actions of the government. The research question of our article was how scientific and professional theory look at the role of deliberative communication, as a model of political communication, in the process of political participation of political stakeholders in the communication community today. We assumed (the hypothesis) that scientific theory looks optimistically at the role of deliberative communication. In the article, we used the descriptive method and the method of analysing scientific and professional texts. We carried out the research with a review of domestic and foreign editions of professional books, monographic publications, original scientific articles, and research results. We obtained data using the Cobiss and Google Scholar databases. The results of the research showed that scientific theory views deliberative communication as a promising experiment and evolution in the realization of deliberative democracy..
Implementation of e-learning curriculum in higher education
Authors: Nkulu-Ily Yves Shabo 
Published: April 2023

Abstract
As some researchers predicted, online education is taking precedence over higher education worldwide. This work deals with this situation using three frameworks appropriate for the three concepts involved (i.e. technology, teacher and students). The literature was reviewed in the context of good-quality education and its relation to three distance-education frameworks. Some approaches and strategies indicate improvement in achieving electronic media-based learning (e-Learning) recognition for better outreach. This manuscript also shows that the most critical aspect of this outreach is thinking about the learning benefits that learners might gain from it and how they might assess those benefits using various tools, not only by direct comparison with old pedagogies or methods.
Acute Hemorrhagic Edema of Infancy - Case Report
Authors: Medovic Rasa , Kostic Gordana , Markovic Slavica , Medovic Marija , Ristic Gordana , Savic Dragana , Simovic Aleksandra , Knezevic-Rangelov Sanja , Igrutinovic Zoran 
Published: April 2023

Abstract
Acute hemorrhagic edema of infancy (AHEI) is a rare vasculitis of small dermal vessels with characteristic presentation in infants aged up to 24 months. It manifests as a sudden occurrence of palpable purpuric skin lesions, swellings in hands, feet, face and auricles, and mild fever. The children affected with AHEI are almost always in good general health and with normal laboratory parameters. Approximately 400 cases have been described in the literature so far. However, the etiology is still unknown. Most evidence suggests infections or vaccination as the principal triggers. Extra cutaneous manifestations are recorded in only about 10% of AHEI patients. The majority of the affected children undergoes recovery spontaneously and without any complications within 1-3 weeks, with or without any treatment. AHEI is usually diagnosed on the clinical grounds only and the diagnostic procedure rarely requires a skin biopsy. The current literature indicates the use of corticosteroids and/or antihistamines as a therapy, but there is still a lot of controversy about these therapeutic measures. This paper presents the case of AHEI with its typical clinical manifestations that resolved in a rapid spontaneous recovery without the use of any treatment within a week. AHEI is a rare syndrome that pediatricians should be well familiar with in order to differentiate it from other potentially severe diseases that have similar cutaneous manifestations, but also to avoid unnecessary investigations and therapy.