bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conversational dynamics of joint attention and shared emotion predict outcomes in interpersonal influence situations: an interaction ritual perspective
Authors: Liao Wang , Oh Yoo Jung , Zhang Jingwen , Feng Bo 
Published: February 2023

AbstractThis article addresses conversational dynamics in interpersonal influence situations. Drawing on interaction ritual theories and the research of interaction processes and patterns, we argue that sequential transition patterns of task and social–emotional acts can capture essences of conversational interaction ritual.A successful ritual then generates emergent solidarity and induces desired outcomes of interpersonal influence. In two experimental situations of online text chats between strangers (advice-giving, Nconversation = 336 with a student sample and compliance-gaining, Nconversation = 737 with a MTurk sample), we found certain transition patterns consistently predicted influence outcomes and interpersonal perceptions. Aligning with our theoretical expectations, these transitions indicate the moment-to-moment emergence of joint attention and shared emotion, which are essential ingredients of a successful interaction ritual.
Sparse tree-based clustering of microbiome data to characterize microbiome heterogeneity in pancreatic cancer
Authors: Shi Yushu , Zhang Liangliang , Do Kim-Anh , Jenq Robert , Peterson Christine B 
Published: February 2023

Abstract
There is a keen interest in characterizing variation in the microbiome across cancer patients, given increasing evidence of its important role in determining treatment outcomes. Here our goal is to discover subgroups of patients with similar microbiome profiles. We propose a novel unsupervised clustering approach in the Bayesian framework that innovates over existing model-based clustering approaches, such as the Dirichlet multinomial mixture model, in three key respects: we incorporate feature selection, learn the appropriate number of clusters from the data, and integrate information on the tree structure relating the observed features. We compare the performance of our proposed method to existing methods on simulated data designed to mimic real microbiome data. We then illustrate results obtained for our motivating dataset, a clinical study aimed at characterizing the tumour microbiome of pancreatic cancer patients.
Identification of a novel adjuvant loperamide that enhances the antibacterial activity of colistin against MCR-1-positive pathogens in vitro/vivo
Authors: Zhang Yuqing , Shi Liming , Lv Lu , Zhang Yan , Chen Huiping 
Published: February 2023

Abstract
Severe infection with multidrug-resistant Enterobacterales caused by the plasmid-induced colistin resistance gene MCR-1 is a serious public health challenge. In this case, it is necessary and pressing to find a treatment to overcome antibiotic resistance. Here, we investigated the synergistic effect and mechanism of loperamide combined with colistin against MCR-1-positive pathogens. We evaluated the combined effect of loperamide and colistin using the checkerboard method and the time-kill experiment. The results showed that loperamide could enhance the bactericidal ability of colistin, and this combination regimen could completely kill the tested bacteria within 4 h. Subsequently, spectrofluorimetric methods were used to explore the mechanism of loperamide combined with colistin. The results indicated that the mode of action of loperamide combined with colistin was found to involve mechanical disruption of the membrane. Furthermore, molecular simulation and microscale thermophoresis results revealed that loperamide reduced the impact of MCR-1 protein by directly binding to its active site. In addition, the combined regimen of loperamide and colistin effectively reduced the bacterial load in the thighs of mice while increasing the protection rate by 70%. In short, as a potential lead compound, loperamide can enhance the killing effect of colistin on pathogenic Enterobacterales carrying MCR-1 by causing membrane damage and inhibiting MCR-1 protein activity.
Microlensing due to free-floating moon-planet systems
Authors: Sajadian Sedighe , Sangtarash Parisa 
Published: February 2023

ABSTRACT
Gravitational microlensing is a powerful method for detecting and characterizing free-floating planetary-mass objects (FFPs). FFPs could have exomoons rotating them. In this work, we study the probability of realizing these systems (i.e. free-floating moon-planet ones) through microlensing observations. These systems make mostly close caustic configurations with a considerable finite-source effect. We investigate finite-source microlensing light curves owing to free-floating moon-planet systems. We conclude that crossing planetary caustics causes an extensive extra peak at light curves’ wing that only changes its width if the source star does not cross the central caustic. If the source trajectory is normal to the moon-planet axis, the moon-induced perturbation has a symmetric shape with respect to the magnification peak, and its light curve is similar to a single-lens one with a higher finite-source effect. We evaluate the Roman efficiency for realizing moon-induced perturbations, which is $\left[0.002-0.094\right]\ \mathrm{ per\, cent}$ by assuming a log-uniform distribution for moon-planet mass ratio in the range ∈ [ −9, −2]. The highest detection efficiency (i.e. $\simeq 0.094~{{\ \rm per\ cent}}$) happens for Saturn-mass planets when moon-planet distance is ∼43Rp, where Rp is the Saturn radius. Enhancing planetary mass extends the event’s time-scale and decreases the finite-source effect, but it reduces the projected moon-planet distance normalized to the Einstein radius s(RE) which in turn decreases the size of planetary caustics and takes them away from the host planet’s position in close caustic configurations.
RFI flagging in solar and space weather low frequency radio observations
Authors: Zhang Peijin , Offringa André R , Zucca Pietro , Kozarev Kamen , Mancini Mattia 
Published: February 2023

ABSTRACTRadio spectroscopy provides a unique inspection perspective for solar and space weather research, which can reveal the plasma and energetic electron information in the solar corona and inner heliosphere. However, radio-frequency interference (RFI) from human activities affects sensitive radio telescopes, and significantly affects the quality of observation. Thus, RFI detection and mitigation for the observations is necessary to obtain high quality science-ready data. The flagging of RFI is particularly challenging for the solar and space weather observations at low frequency, because the solar radio bursts can be brighter than the RFI, and may show similar temporal behaviour. In this work, we investigate RFI flagging methods for solar and space weather observations, including a strategy for aolagger, and a novel method that makes use of a morphology convolution. These algorithms can effectively flag RFI while preserving solar radio bursts.
Activity of Anlotinib in the Second-Line Therapy of Metastatic Gastrointestinal Stromal Tumors: A Prospective, Multicenter, In Vitro Study
Authors: Zhou Yongjian , Zeng Chunling , Sun Xiaofeng , Zhang Jun , Qu Hongyan , Zhang Xinhua , Zhou Ye , Liu Zimin , Wu Xiaojun , Wu Xin , Jiao Xuelong , Shen Lin , Zhou Yanbing , Wang Yuexiang , Li Jian 
Published: February 2023

AbstractBackgroundAnlotinib is a multi-target tyrosine kinase inhibitor that can effectively inhibit tumor cell proliferation after receptor kinase activation caused by KIT gene mutation.MethodsWe tested the inhibitory effect of anlotinib in GIST cell lines with different gene mutations and evaluated the efficacy of anlotinib for patients with metastatic GIST after imatinib failure in a multicenter, single-arm, phase II study.ResultsIn vitro, V654A mutation encoded by KIT exon 13 was intermediately sensitive to anlotinib. Moreover, anlotinib was able to partly suppress the activation loop mutation D820A from exon 17 while another activation loop mutation N822K, also from exon 17, was resistant to anlotinib. From September 2018 to October 2020, 64 patients from 9 Chinese medical centers were enrolled in this study. Seven patients had partial response and 39 patients had stable disease. The median PFS was 8.0 months. There was no statistical significance comparing with PFS of sunitinib second-line therapy at the same period. The most common adverse events related to anlotinib treatment were hypertension, neutropenia, and fatigue.ConclusionAnlotinib showed moderate antitumor activity in drug-resistant GIST cell lines in vitro, and good PFS and better tolerance in second-line therapy study.
The RNA‐binding protein Snd1/Tudor‐SN regulates hypoxia‐responsive gene expression
Authors: Saarikettu Juha , Lehmusvaara Saara , Pesu Marko , Junttila Ilkka , Partanen Juha , Sipilä Petra , Poutanen Matti , Yang Jie , Haikarainen Teemu , Silvennoinen Olli 
Published: February 2023

AbstractSnd1 is an evolutionarily conserved RNA‐binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the outcome of Snd1 gene deletion in the mouse. The knockout mice are viable showing no gross abnormalities apart from decreased fertility, organ and body size, and decreased number of myeloid cells concomitant with decreased expression of granule protein genes. Deletion of Snd1 affected the expression of relatively small number of genes in spleen and liver. However, mRNA expression changes in the knockout mouse liver showed high similarity to expression profile in adaptation to hypoxia. MicroRNA expression in liver showed upregulation of the hypoxia‐induced microRNAs miR‐96 and ‐182. Similar to Snd1 deletion, mimics of miR‐96/182 enhanced hypoxia‐responsive reporter activity. To further elucidate the function of SND1, BioID biotin proximity ligation assay was performed in HEK‐293T cells to identify interacting proteins. Over 50% of the identified interactors were RNA‐binding proteins, including stress granule proteins. Taken together, our results show that in normal growth conditions, Snd1 is not a critical factor for mRNA transcription in the mouse, and describe a function for Snd1 in hypoxia adaptation through negatively regulating hypoxia‐related miRNAs and hypoxia‐induced transcription consistent with a role as stress response regulator.
Parents of Children with Cleft Lip Exhibit Heightened Visual Attention to the Perioral Area
Authors: Abuelezz Israa , Qaraqe Marwa K. , Stotland Mitchell A. 
Published: February 2023

Background:
Following high-quality surgical repair, children born with a cleft lip anomaly may still display lasting visual differences. We exposed control adults and parents of affected children to images of children with cleft deformity and compared their visual tracking patterns. The protocol investigated whether parental exposure to secondary cleft deformity heightens or diminishes visual attraction to this type of structural facial variation.

Method:
Twenty participants (10 control adults, 10 parents of affected children) assessed 40 colored images of children's faces while their eye movements were tracked. Twenty-four control images and 16 repaired cleft lip images were displayed to observers. Nine bilateral facial aesthetic zones were considered as regions of interest. Percentage of time visually fixating within each region, and statistical differences in fixation duration percentage between the two participant groups and across the bilateral regions of interest were analyzed.

Results:
While both groups of observers directed more visual attention to the nasal and oral regions of the cleft images than control images, parents of children with cleft lip spent significantly more time fixating on these areas (25% and 24% of the time, respectively) than did unaffected adults (14.6% and 19.3%; P < 0.001).

Conclusions:
These results demonstrate that parents of cleft lip children exhibit heightened attention to this type of facial difference relative to the naive observer. These findings highlight that observer profile can meaningfully influence the perception of a facial deformity. Awareness of this information may enhance communication between surgeon and parents of an affected child by providing added insight into parental perspective.
Modified Antia-Buch Flap Incorporating an Extended Temporal Scalp Incision
Authors: Maglic Dino , Sudduth Jack D. , Marquez Jessica L. , Tieman Joshua , Overschmidt Bo , Siddiqi Faizi , Gociman Barbu 
Published: February 2023

Background:
The Antia-Buch flap is a popular reconstructive method for full-thickness ear defects involving the helical rim. However, scaphal or conchal resection is often required to prevent ear distortion. Noel et al described a modified technique to the Antia-Buch flap, which includes an incision in the temporal scalp and complete detachment of the preauricular helical root to increase mobility of the flap. Since then, no studies have reported on the use of this modification. We report our experience in implementing Noel et al’s modification of the Antia-Buch flap for helical rim defects.

Methods:
The modified technique differs from the original Antia-Buch flap by completely detaching the root of the helix and adding a vertical incision to the temporal scalp to increase mobility of the flap. No scaphal resection is necessary. After complete elevation of the flaps, the flaps are advanced and inset toward each other followed by closure.

Results:
In our practice, 10 patients have been treated with Noel et al’s modification to the Antia-Buch flap. In each of these patients, acceptable reconstruction of the helical rim was able to be achieved. All the patients were pleased with their reconstructive outcome and ear anatomy was able to be successfully maintained.

Conclusions:
The modified Antia-Buch flap has shown to be an excellent method for large, helical rim defects, creating versatility by adding the temporal scalp incision. Our outcomes with Noel et al’s modification to the original Antia-Buch flap support this method as a versatile technique for wide full-thickness helical rim defects.
Validation of the A&D UM-212BLE monitor according to ISO 81060-2, 2018: a device with clinically important programmability
Authors: Alpert Bruce S. 
Published: February 2023

Objective
The objective of this report was to describe the validation of the A&D UM-212BLE automated oscillometric sphygmomanometer to the ISO 81060-2, 2018 protocol. The device is specifically designed for enhanced office and out-of-office programmability.

Methods
A combined pediatric (n = 35) and adult (n = 50) population was studied at Clinmark LLC in Louisville, Colorado, USA. Same-arm sequential testing was performed following the ISO 81060-2, 2018 requirements. Five cuffs were tested with a total arm circumference range from 12 to 50 cm. Reference readings were done by two blinded observers performing simultaneous auscultation.

Results
For validation of Criterion 1 the mean ± SD (mmHg) of the device minus the reference differences were 3.94 ± 6.89 for SBP and 2.09 ± 6.68 for DBP. Both passed the Standard limits for Criterion 2; the systolic(S)SD achieved was 5.56 (5.70 permitted) and the diastolic(D)SD was 6.01 (6.62 permitted). All other Standard requirements were met.

Conclusions
The UM-212BLE passed all requirements. The features that make this device clinically superior include settings for automated office BP, variable pressure inflation, dual measurement modes (oscillometry, auscultation), the wide range of cuffs tested, automated irregular heartbeat detection, and full validation in a pediatric population. The inclusion of all of these features makes the UM-212BLE a highly attractive device for both office and out-of-office BP estimation.
A Quality Improvement Project to Decrease Suboptimal Patient Transfers between Two Neonatal Units
Authors: Douglas Kiane A. , Eriobu Chinonye , Sanderson Ann , Tumin Dmitry , Akpan Uduak S. 
Published: February 2023

Introduction.
Poorly executed transitions of care in health care systems are associated with safety concerns and patient dissatisfaction. We noticed several problems in the transfer process between our neonatal intensive care unit (NICU) and special care nursery (SCN) and designed this quality improvement project to address them. The aim was to decrease suboptimal transfers from the NICU to the SCN by 50% over 9 months. We defined suboptimal transfers as the discharge of a patient within 3 days of transfer from the NICU to the SCN or the return of a patient to the NICU within 5 days of the transfer.

Methods.
We formed a multidisciplinary team and collected baseline data from October 2019 to December 2020. Major interventions included implementing a transfer checklist and algorithm. We utilized 3 staff surveys to evaluate the progress of the project. We used statistical process control charts to track project measures over time.

Results.
Patient demographics and SCN length of stay were similar for the baseline and postintervention periods. We decreased suboptimal transfers over 21 months (January 2021 to September 2022), achieved a significantly increased rate of parent notification before transfers (81% baseline versus 93% postintervention), and increased staff satisfaction with the transfer process (15% baseline versus 43% postintervention).

Conclusions.
We successfully improved the transfer process from our NICU to the SCN via a quality improvement project. Increased staff satisfaction and the lack of perception of additional burden to the staff from the new process are expected to sustain our results.
Skin-fat composite grafts for reconstructing large full-thickness skin defects
Authors: Jang Young Chul , Burm Jin Sik , Cho Jaeyoung 
Published: February 2023

Background:
The uppermost layer of subcutaneous tissue has a rich vascular network, the subdermal plexus and multiple perforating vessels in the interlobular septa. When skin-fat composite grafts (SFCGs) include this uppermost layer, they can be readily vascularized to enhance survival. We describe our clinical experience with large-sized SFCG transplantations.

Methods:
This retrospective study included patients that underwent SFCG transplantation for large, full-thickness skin defects, formed after burn scar contracture or contraction deformity excision. The recipient tissue bed was prepared by retaining the deepest layer of scar tissue or reticular dermis to preserve the interlobular septa, subdermal plexus, and ascending arterioles above the subcutaneous tissue. The SFCG was prepared by trimming fat lobules and preserving the interlobular septa and vessels to form a 1-4-mm thick base of subdermal fat tissue. The trimmed SFCG was placed onto the defective tissue and secured with a tie-over dressing.

Results:
Among 86 grafts, 76 (88.4%) survived completely (sizes: 6 to 161 cm 2, mean surface area 68.7cm 2). Focal skin sloughing or graft loss occurred in 10 cases. These events were followed by spontaneous healing in 8 cases. Focal hypertrophic scars formed in 6 cases. In 15 cases, hyperpigmentation occurred, but improved gradually. Most transplantations achieved satisfactory pliability (93.0%), contour (90.7%), and color (88.4%).

Conclusions:
SFCGs survived better than expected with minimal complications, probably due to the preservation of rich vascular networks in both the recipient and SFCG tissues. Therefore, SFCG transplantation may be a good option for reconstructing full-thickness skin defects in a large surface area.
Total breast reconstruction with lipofilling after traditional mastectomy without the use of tissue expanders
Authors: Homsy Pauliina , Höckerstedt Anna , Hukkinen Katja , Kauhanen Susanna 
Published: February 2023

Background:
Lipofilling can be used to reconstruct a breast without additional implants or autologous composite grafts. However, methods to maximize retention of the transferred fat remain under debate. Here we present our experience of breast reconstruction with lipofilling without concomitant use of tissue expanders.

Methods:
Patients who had completed breast reconstruction with lipofilling between June 2010 and June 2016 were reviewed. Those with obtainable follow-up MRI imaging were included in this cross-sectional study. The hospital records were reviewed for details of the lipofilling operations. MRI images were evaluated for the volume retention and quality of the transferred fat. The patients were asked to assess the appearance and sensitivity of the reconstructed breast, the recovery time, and any adverse effects at the fat donor area.

Results:
38 women with 41 reconstructed breasts were included in the study. The median age at follow-up was 62 (range 48-78). They had undergone a median 4 (2-6) lipofilling procedures with a median total volume 690 (369-1350)ml. After a median 2.1 (0.4-6.8) year follow-up, the median proportion of transferred fat retained was 58 (14-119)%, representing reconstructed breast volume 76 (17-100)% of the contralateral breast. Oil cysts larger than 10mm were detected in 7%. Most patients reported being satisfied with the reconstructed breast and experienced few side effects.

Conclusions:
Breast reconstruction with lipofilling can be performed with an acceptable number of procedures and no preoperative skin expansion. It extends the option of autologous breast reconstruction to women unsuitable for major reconstructive procedures.
Objectifying the Antagonistic Role of the Depressor Anguli Oris Muscle in Synkinetic Smile Formation Utilizing High-Resolution Ultrasound- A Prospective Study
Authors: Kehrer Andreas , Ruewe Marc , Klebuc Michael , Platz Batista da Silva Natascha , Lonic Daniel , Heidkrueger Paul , Knoedler Samuel , Jung Ernst-Michael , Prantl Lukas , Knoedler Leonard 
Published: February 2023

Background:
In facial palsy (FP) patients synkinesis of the Depressor Anguli Oris muscle (DAO) is a common pathology impairing dynamic and resting facial symmetry. This prospective study utilizes high-resolution ultrasound (HRUS) to evaluate the morphological features of the DAO and to quantify bilateral differences in DAO cross-sectional diameter (CSD) in individuals with unilateral synkinesis.

Methods:
From June 2020 to May 2021 30 patients (19 women, 11 men) with clinically diagnosed unilateral synkinesis underwent evaluation with HRUS. DAO, CSD was measured bilaterally, 1 cm inferior to the modiolus in both the resting and smiling positions.

Results:
The Sunnybrook Facial Grading System Synkinesis Score was 6.20 ± 2.48 [0 – 10]. DAO CSD at rest measured 2.41 ± 0.67 mm [1.40 - 4.00 mm] on the control side and 2.66 ± 0.98 mm [1.60 - 5.10 mm] on the affected side, respectively. The DAO on the control side, CSD reduced by - 0.19 ± 0.43 mm [-1.10 - 1.12 mm] when smiling. In contrast, the synkinetic DAO CSD increased by 0.64 ± 0.38 mm [0.00 - 1.59 mm] (p< 0.001) with animation.
The pattern of increased CSD in synkinetic DAO muscles and decreased or unchanged CSD on the control side when smiling was identified in 70% of patients.

Conclusions:
High resolution ultrasound demonstrates increased CSD in synkinetic DAO muscles during active smiling. The opposite is true for DAO muscles on the control side that exhibit decreased CSD with animation. HRUS may be performed preoperatively to objectify DAO dysfunction and guide targeted therapy.