bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment and Application of the BRP Prognosis Model for Idiopathic Pulmonary Fibrosis
Authors: Cheng Xiaoyun , Feng Zhichao , Pan Boyu , Liu Qingxiang , Han Yuanyuan , Zou Lijun , Rong Pengfei , Meng Jie 
Published: July 2023

Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial lung disease, with varying disease progression and prognosis. Clinical models to accurately evaluate the prognosis of IPF are currently lacking.
Objective
To train and validate a prediction model for transplant-free survival (TFS) of IPF based on the clinical and radiological information.
Methods
A multicenter prognostic study was conducted, involving 166 IPF patients followed up for three years. The end point of follow-up was death or lung transplantation, and the outcome indicator was TFS. The clinical information, lung function tests, and chest computed tomography (CT) scans were collected. Body composition quantification on CT was performed using 3D Slicer software. Risk factors in Blood routine examination-Radiology-Pulmonary function (BRP) were identified by Cox regression, and were utilized to construct the “BRP Prognosis Model”. The performance of the BRP model and the gender-age-physiologic variables (GAP) was compared using time-ROC curve, calibration curve, and decision curve analysis (DCA). Kaplan-Meier and Log-rank tests were used for risk stratification based on individual BRP scores. Furthermore, the Spearman correlation analysis was utilized to explore the correlation between body composition, lung function and serum inflammatory cytokines.
Results
Our study identified neutrophil percentage༞68.3%, pericardial adipose tissue (PAT)༞94.91 cm3, pectoralis muscle radiodensity (PMD) ≤ 36.24 HU, diffusing capacity of the lung for carbon monoxide/alveolar ventilation (DLCO/VA) ≤ 56.03%, and maximum vital capacity (VCmax)༜90.5% as independent risk factors for poorer TFS among patients with IPF. We constructed BRP model, which showed superior accuracy, discrimination, and clinical practicability to GAP model. Median TFS differed significantly among patients at different risk levels identified by the BRP model (low-risk: TFS > 3 years; intermediate-risk: TFS = 2–3 years; high-risk: TFS ≈ 1 year). Additionally, serum proinflammatory markers were positively correlated with visceral fat volume and infiltration, and negatively correlated with lung function indicators.
Conclusion
In this study, the BRP prognostic model of IPF was successfully constructed, and internally and externally validated. Compared with the most commonly used GAP, the BRP model had better performance and generalization with easily obtainable indicators. The BRP model is suitable for clinical promotion.
Cardiorenal effects of sodium glucose cotransporter 2 inhibitors in patients with diabetic and non-diabetic chronic kidney disease: A system review and meta-analysis
Authors: Zhou Lingyan , Zhang Ying , Huang Zijia , Xu Ting , Li Yuwen 
Published: July 2023

Abstract
Purpose
To estimate the cardiorenal benefits and safety outcomes of SGLT-2 inhibitors in chronic kidney disease patients with and without diabetes.
Methods
We did a systematic review and meta-analysis of randomized, placebo-controlled, cardiovascular and kidney outcome trials of SGLT-2 inhibitors in patients diagnosed with chronic kidney disease (CKD). PubMed, Embase and Cochrane library database were searched for eligible studies published up to March 10, 2023. The RoB 2.0 tool was utilized to assess the bias risk of the enrolled trials. Review Manager (version 5.3) was used for meta‐analysis.
Results
Four RCTs encompassing 21,031 participants with CKD were enrolled, and 4,967 of whom had no history of diabetes at randomization. Pooled analyses demonstrated that SGLT-2 inhibitors were associated with reduced risk of cardiorenal outcomes in CKD patients with diabetes (RR = 0.70, 95% CI: 0.64–0.77, p < 0.001), and reduced the risk of progression of nephropathy in CKD patients without diabetes (RR = 0.70, 95% CI: 0.49–0.99, p = 0.04).
Conclusions
Current evidences suggest that SGLT-2 inhibitors reduce the cardiorenal risk in CKD patients with diabetes, and nephroprotective effects of SGLT-2 inhibitors were identified in CKD patients without diabetes.
Protocol registration:
This review is registered in prospective register of systematic reviews (PROSPERO CRD42023404821).
The Importance of Seismic Microzonation under the Threat of an Earthquake of the North Anatolian Fault in Nilüfer, Bursa, Turkey
Authors: Bıçakcı Güldane Boyraz , Özçep Ferhat , Karabulut Savaş , Cengiz Mualla 
Published: July 2023

Abstract

The district of Nilüfer experienced the most recent urbanization among the central districts of Bursa in South Marmara with completion of rapid construction. Since 358 BC, there were many destructive earthquakes on the branches of the North Anatolian Fault reported which caused great damage in the city of Bursa and cost many lives. Besides some studies conducted to define the soil behaviour in the vicinity of Bursa, the seismic hazard of Nilüfer and the surrounding region remains a problem. In this study, an earthquake hazard analysis was first conducted and the peak ground acceleration (PGA) values were determined with respect to an expected earthquake. In the next step, MASW (Multi-Channel Analysis of Surfave Wave) measurements were conducted at 54 points in 28 neighborhoods of Nilüfer district. Soil mechanical parameters were determined at 11 boroholes, which were calculated as the probability of liquefaction. It was found that almost half of the study area suffers from low damage considering only the vulnerability index (Kg) index, which depends on the site effect. Therefore, in addition to the Kg values, we created a microzonation map using the results by soil liquefaction, settlement, changes of ground water level and the average values of spectral acceleration. The results showed four different areas with low to high damage. Altınşehir, Hippodrome, Ürünlü and Alaaddinbey, Ertuğrul, 29 Ekim, 23 Nisan, Ahmetyesevi and Minareliçavuş districts also have high risk of damage levels that could not be quantified by Kg index alone. The results of this study clearly show that considering the Kg index, which depends only on the local site effect, may lead to inadequate damage values.
An analysis and visualization of postherpetic neuralgia research between 1985 and 2022 using scientometrics
Authors: Cao Xueqin , Zhang Mi , Zhang Caixia , Jiao Bo , Zheng Hua , Zhang Xianwei 
Published: July 2023

Abstract

Background This study aimed to highlight the status of research on PHN between 1985 and 2022 through a bibliometric analysis and a historical review. Methods The Web of Science database was searched, and 3,386 relevant articles were included in the study. Bibliometric analysis was used to review the field distribution, regional distribution, and research topic evolution. Results Trends identified in the literature indicate that research on PHN is increasing globally. The United States is the leading country, and the University of California system is the leading institution in terms of publications. Glaxosmithkline had the highest number of citation bursts, indicating its important role in PHN research and drug development. PHN is primarily associated with older age and immunosuppression. Treatment mainly involves pharmacological, nonpharmacological, and interventional treatments, although data supporting the use of physical interventions are lacking. The main psychophysiological effects experienced by patients with PHN are anxiety, insomnia, and depression. Additionally, PHN results in a significant economic burden. Two vaccines have been approved for herpes zoster. Finally, animal models of PHN are inadequate. Conclusions The findings of this study provide valuable information for future research on PHN, e.g., research is needed on the mechanism of PHN, the development of suitable animal models, and the long-term effects of interventional treatment.
Policy and Market Forces Delay Inevitable Real Estate Price Declines on the Coast
Authors: Smith Martin , McNamara Dylan , Williams Zachary , Gopalakrishnan Sathya , Landry Craig 
Published: July 2023

Abstract
Despite increasing risks from sea-level rise (SLR) and storms, coastal communities continue to attract wealthier residents, and coastal property values continue to rise. To understand this seeming paradox and explore policy responses, we develop the Coastal Home Ownership Model (C-HOM) and analyze the long-term evolution of coastal real estate markets. C-HOM incorporates changing physical attributes of the coast, economic values of these attributes, and dynamic risks associated with storms and flooding. Resident owners, renters, and non-resident investors jointly determine coastal property values and the policy choices that influence the physical evolution of the coast. In the coupled system, we find that subsidies for coastal management, such as beach nourishment, tax advantages for high-income property owners, and stable or increasing property values outside the coastal zone all dampen the effects of SLR on coastal property values. The effects, however, are temporary and only delay precipitous declines as total inundation approaches. By removing subsidies, prices would more accurately reflect risks from SLR but also trigger more coastal gentrification, as wealthier owners enter the market and self-finance nourishment. Our results suggest a policy tradeoff between slowing demographic transitions in coastal communities and allowing property markets to adjust smoothly to risks from climate change.
Improving Nonalcoholic Fatty Liver Disease Classification Performance With Latent Diffusion Models
Authors: Hardy Romain , Mitchell Ryan , Klepich Joe , Hall Steve , Villareal Jericho , Ilin Cornelia 
Published: July 2023

Abstract
Integrating deep learning with clinical expertise holds great potential for addressing healthcare challenges and empowering medical professionals with improved diagnostic tools. However, the need for annotated medical images is often an obstacle to leveraging the full power of machine learning models. Our research demonstrates that by combining synthetic images, generated using diffusion models, with real images, we can enhance nonalcoholic fatty liver disease (NAFLD) classification performance. We evaluate the quality of the synthetic images by comparing two metrics: Inception Score (IS) and Fréchet Inception Distance (FID), computed on diffusion-generated images and generative adversarial networks (GANs)-generated images. Our results show superior performance for the diffusion-generated images, with a maximum IS score of 1.90 compared to 1.67 for GANs, and a minimum FID score of 69.45 compared to 99.53 for GANs. Utilizing a partially frozen CNN backbone (EfficientNet v1), our synthetic augmentation method achieves a maximum image-level ROC AUC of 0.904 on a NAFLD prediction task.
BAFF, but not APRIL, initiates Chronic Lymphocytic Leukemia by inducing tumor-promoting genes rather than cell survival.
Authors: Mackay Fabienne , Ullah Md Ashik , Garcillán Beatriz , Whitlock Eden , Figgett William , Infantino Simona , Eslami Mahya , Yang SiLing , Rahman M Arifur , Sheng Yong , Weber Nicholas , Schneider Pascal , Tam Constantine , Mackay Fabienne 
Published: July 2023

Abstract
Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults, characterized by the expansion of CD19+ CD5+ B cells. The origin of CLL remains debated, with one model suggesting that CLL cells carrying mutations in the variable regions of immunoglobulin are derived from post-germinal center B cells, whereas unmutated CLL cells originate from CD5+ mature B cell precursors. The cytokines BAFF and APRIL each play a significant role in CLL cell survival and accumulation, but their involvement in disease initiation is unclear. Using the TCL1-transgenic (Tg) model, we have demonstrated that BAFF, but not, APRIL is needed for the initiation and dissemination of CLL. In the absence of BAFF or its receptor BAFF-R, expression of the TCL1 transgene increases CLL cell numbers in the peritoneal cavity but does not allow dissemination into the periphery. BAFF binding to BAFF-R is not required for the survival of peritoneal CLL cells but for the expression of tumor-promoting genes, likely allowing peritoneal CLL cells to disseminate to other sites to drive CLL. Our findings unveil BAFF as an unrecognized tumor-promoting cytokine in CLL. Combining current CLL therapies with BAFF inhibition may offer dual benefits: reducing peripheral tumor burden and suppressing transformed CLL cell output.
Physical activity in liver transplant recipients: a large multicenter study
Authors: Gitto Stefano , Golfieri Lucia , Gabrielli Filippo , Falcini Margherita , Sofi Francesco , Tamè Maria Rosa , De Maria Nicola , Marzi Luca , Mega Andrea , Valente Giovanna , Borghi Alberto , Forte Paolo , Cescon Matteo , Benedetto Fabrizio Di , Andreone Pietro , Petranelli Marco , Morelli Maria Cristina , De Simone Paolo , Lau Chloe , Stefani Laura , Vizzutti Francesco , Chiesi Francesca , Marra Fabio , GROUP MEDITRA RESEARCH 
Published: July 2023

Abstract
Aim
Healthy lifestyle and appropriate diet are of critical importance after liver transplant (LT). The present study was undertaken to analyse the impact of physical activity in a large cohort of LT recipients.
Methods
Clinically stable LT recipients were enrolled between June and September 2021. Patients completed a composite questionnaire about physical activity, adherence to Mediterranean Diet (MD), quality of life (QoL), and employment. Correlations were analysed using the Pearson coefficients while different subgroups were compared by t-test for independent samples or ANOVAs. Multivariable logistic regression analysis was conducted to find predictors of inactivity.
Results
We enrolled 511 subjects (71% males, mean age 63 ± 10.8 yrs). One hundred and ninety-three patients reported high level of physical activity, 197 a minimal activity and 121 declared insufficient activity. Among these latter, 29 subjects were totally inactive. Considering the 482 LT recipients performing some kind of physical activity, almost all reported a low-quality, non-structured activity. At multivariate analysis, time from LT (odds ratio 0.94, 95% CI 0.89–0.99, p = 0.017), sedentary lifestyle (odds ratio 0.99, 95% CI 0.19–0.81, p = 0.012), low adherence to MD (odds ratio 1.22, 95% CI 1.01–1.48, p = 0.049), and low level of QoL (physical dimension) (odds ratio 1.13, 95% CI 1.08–1.17, p < 0.001), were independently associated with total inactivity.
Conclusions
A large portion of LT recipients report an insufficient level of physical activity or are wholly inactive. Inactivity increases with time from LT, and was strongly associated with suboptimal diet and low QoL.
Screening for Porcine Deltacoronavirus in Human Serum Samples Via a Luminescent Immunoprecipitation System
Authors: Boley Patricia A. , Lemon Grace , Kenney Scott 
Published: July 2023

Abstract
Porcine deltacoronavirus (PDCoV) is an emerged coronaviral disease of swine circulating globally. The ability of PDCoV to infect avian and mammalian species and its recognized zoonotic capabilities make it an important pathogen to monitor for spread in humans. Here we present a pilot study in which 200 human serum samples from Midwest and East coast sites in the United States (U.S.) were screened utilizing a luminescent immunoprecipitation system. All samples tested negative for reactivity to PDCoV proteins suggesting that exposure to PDCoV is not yet widespread. Increased targeted serological surveys are needed to define the current incidence rates of PDCoV in humans
Integrative genomic analysis reveals cancer-associated mutations at the diagnosis of cancer in patients with ocular tumors
Authors: Zhu Fengjiao , Wang Pengpeng , Zhang Zhiyuan , Yao Chunlei , Ii Jie , Ye Juan , Wu Jian 
Published: July 2023

Abstract
The genomic events associated with poor outcomes in other ocular tumors are poorly understood, except for the in-depth study of the retinoblastoma Rb gene. We investigated 48 patients with ocular tumors, using three types of samples - cancerous tissue, paraneoplastic tissue, and peripheral blood. We employed combined exome and transcriptome analysis to search for high-frequency mutated genes and susceptibility genes in ocular tumors. Our exon sequencing analysis identified four clear causative genes (TP53, PTCH1, SMO, BAP1), most of which were associated with basal cell carcinoma. Two mutations in BAP1 were clearly associated with choroidal melanoma, and no clear causative loci were found in other cancer types. Our susceptibility gene analysis identified hotspot genes such as RUNX1, APC, IDH2, and BRCA2. High-frequency gene analysis identified TP53, TTN, and MUC16 genes, among others. Transcriptome analysis identified TOP2A and ZWINT genes were upregulated in all samples, while CFD, ELANE, HBA1, and HBB were downregulated. Our KEGG enrichment analysis indicated that the PI3K-Akt signaling pathway and transcriptional misregulation in cancer may be involved in the process of ocular tumorigenesis. We found that TP53 is clearly involved in ocular tumorigenesis, especially in basal cell carcinoma, and its PI3K-Akt signaling pathway may be an essential pathway involved in ocular tumorigenesis. Additionally, RUNX1, SMO, TOP2A, and ZWINT are highly likely to be involved in ocular tumorigenesis, and subsequent functional experiments can be carried out to verify the mechanisms of these genes in regulating tumorigenesis.
Photocatalytic performance of CeO2 , SnO2 nanoparticles catalysed by Methylene Blue (MB) dye degradation
Authors: G Ramanathan , N Srinivasan @ Arunsankar , K Syed Suraj Babu , A Syed Mohammed Mujaheer , R Murali K , S Sakthiya 
Published: July 2023

Abstract
Cerium oxide (CeO2), Tin oxide (SnO2) nanoparticle powders were synthesized by two different methods one is co-precipitation method using the leaf of Artemisia pallens (cerium (III) nitrate ) and another one is sol gel Acrylamide route. The prepared CeO2 powders and SnO2 were characterized by various analysis tools. The powder X-ray diffraction analysis results revealed that the sample powder was crystalline with single phase cubic structure. The broad peaks show the nanosized crystal and also crystallite size increase with temperature due to the agglomeration of individual particles. The variation in particle size, lattice strain, stress and energy density calculated by various method such as Debye’s Scherer, Monshi method and Williamson-Hall method. The line broadening of CeO2 nanoparticles was due to the small crystallite size and lattice strain. This broadening was analyzed by the Scherer formula, modified forms of W-H analysis. This variation in particle size, lattice strain, stress and energy density reveals that non uniform strains in the particles. This non uniform strain was increased when the particle size was increased. CeO2 ultrafine nanopowder with spherical particles and an average size between 4 and 16 nm was discovered using transmission electron microscopy (TEM). In the High Resolution TEM pattern, the average distance between two consecutive fringes is 0.31 nm. Photocatalytic degradation of MB catalysed by as synthesized CeO2 nanoparticles and Tin oxide nanoparticles. From the observation to measure the pseudo first order rate constant of the MB dye were computed for two different catalyst Nps. The removal efficiency of MB dye using ceria which indicate has higher efficiency (95%) compared to Tin oxide catalysts (93%) within 180 min 19mg/l cerium oxide caused the most deterioration. The obtained results indicate the effect of photogenerated holes in the degradation mechanism of the dye. Cerium oxide material was analyzed using BET surface analysis methodologies while keeping in mind the photocatalytic activity efficiency results. A Brunauer–Emmett–Teller (BET) technique is very important surface analysis technique for the measurement of the specific surface area of materials. From this techniques surface area and pores sizes are directly measured at different temperature. The pores diameter varies from 3 to 9 nm and the average diameter of pores did not exceed 10 nm. As the calcinations temperature increased, the average pore size increased from 3.3 to 9.1 nm.
Influence of light absorption rate on the astaxanthin production by the microalga Haematococcus pluvialis during nitrogen starvation
Authors: SAMHAT Khadija , KAZBAR Antoinette , TAKACHE Hosni , ISMAIL Ali , PRUVOST Jeremy 
Published: July 2023

Abstract
Large amounts of astaxanthin (about 4% DW) can be produced under nitrogen starvation of Haematococcus pluvialis in photobioreactors (PBRs) exposed to high light to induce a light stress. However, in PBR, the large biomass concentration usually achieved leads to strong light attenuation conditions, which makes complex the analysis of this “light stress”. This study aims then to elucidate the role of light transfer in astaxanthin cell content and productivity from the microalga Haematococcus pluvialis during nitrogen starvation.
In order to obtain several light attenuation conditions in the culture volume, H. pluvialis was cultivated in a flat-panel PBR in sudden nitrogen starvation conditions with different initial biomass concentrations (Cx0) of 0.21, 0.52, 1.39 and 2.21 kg m− 3 in batch mode and exposed to an incident photons flux density (PFD) of 250 µmolhν m− 2 s− 1. First, spectral mass absorption cross-sections of H. pluvialis were measured at different times during nitrogen starvation. They were then used to relate the mean rate of photons absorption (MRPA) to the astaxanthin productivity and cell content.
A minimum initial MRPA of 7000 µmolhν kgx−1 s− 1 was found necessary at the onset of nitrogen starvation to trigger large accumulation of astaxanthin in H. pluvialis cells, up to 3.21% DW. The results also demonstrated the existence of a relation between the MRPA and the daily astaxanthin productivity of H. pluvialis cultures, introducing then the MRPA as a physical quantity of interest for a rational optimization of the light culture conditions in PBRs.
Study on bending performance of prefabricated glulam-cross laminated timber composite floor with screw connections
Authors: Du Hao , Chen Gang , Fu Weijie , Hu Xiamin 
Published: July 2023

Abstract
The glulam-cross laminated timber (CLT) composite floor is a type of prefabricated composite floor that integrates glulam beams and CLT slab into a unified structure using shear connectors. To investigate the bending performance of the glulam-CLT composite floor, the bending test was conducted on a full-scale composite floor under static load. The study comprehensively analyzed the failure mechanism, load-deflection behavior, interface slip and strain distribution of the glulam-CLT composite floor. The test results of the composite floor indicated that the failure mode was tensile fracture of the wood beam at the bottom. As the load increased, the relative slips extended towards the mid-span, and the rate of increase in relative slip gradually increased, which could be attributed to the decrease in shear stiffness of the screw connections and the overall composite action. In the earlyloading phase, the strain distribution of the composite section satisfied the assumption of a plane section. However, the strain distribution deviated from this assumption with the increased load due to the relative slips between the glulam beam and CLT flange. To calculate the bending performance of the composite floor, the M-shaped section of the glulam-CLT composite floor was simplified as T-section composite beams. The linear-elastic method for determining the flexural rigidity and ultimate bearing capacity of the glulam-CLT composite floors was proved to be accurate and reliable.