bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Process of Primary School Science Learning and Teaching During the Art Activities Integrated Lessons
Authors: Demir Zülfiye Melis , Gültekin Mehmet 
Published: May 2023

Abstract

The purpose of this research is to determine the effects of the learning-teaching process carried out by integrating the science course of the fourth grade of elementary school with art activities on learning products. The research was designed as a qualitative research method. Participants of the research were 4th grade 20 students in a public primary school, and 9 parents of students attended the research during the 2020–2021 academic year. The data of the research collected by video recordings of lessons, student products and interview transcriptions. During the art integrated science course artworks were created with different applied arts like “Painting, Music, Sculpture, Literature, Interior Architecture, Graphic Design, Industrial Product Design and Digital Arts”, art criticism and art history. Qualitative data were analysed with thematic analysis. As a result of the analysis of the qualitative data, it was concluded that the students had achievements under five themes: “cognitive dimension”, “artistic dimension”, “environmental awareness dimension”, “affective dimension” and “distance education dimension”.
Aspirin Administration can not Improve Erectile Dysfunction, whether with Higher Dosage or Longer Duration
Authors: Li Tao , Jiang Yiting , Shan Gang , Luo Chao , Du Guangshi , Qi Xinzhu , Tian Ye , Luo Fu , Tian Yuan , Gu Jiang 
Published: May 2023

Abstract
Background Aspirin is the most widely used medicine since its synthesis, we aim to investigate the controversial relationship between aspirin and erectile function.Methods Thirty-six healthy young rats were grouped and administrated with small (10 mg/kg/d) and big (150 mg/kg/d) dose aspirin for 1 and 3 months, respectively; eighteen rats with bilateral cavernous nerve crush (BCNC) process were gavaged with small dose aspirin for 1 month. The 6-keto PGF1a, PGE2, and TXB2 in corpus cavernosum were detected to verify the bioactivity of aspirin. The mICP, mICP/MAP ratio, and concentrations of total NO, cAMP, as well as cGMP were selected to determine the erectile function.Results For the healthy young rats, aspirin significantly decreased the 6-keto PGF1a and PGE2 levels than control group, however, mICP, mICP/ MAP, total NO, cAMP, and cGMP levels was similar, whether with bigger dosage or longer duration. In BCNC groups, aspirin also significantly inhibited prostaglandin productions, however, it did not improve the impaired erectile function as well.Conclusion Long-term aspirin (even with higher dosage or longer duration) administration did not strength nor deteriorate erectile function for healthy young rats, while it did not improve the BCNC-induced erectile dysfunction as well.
Helicopter Parenting and Chinese University Students' Adjustment:The Mediation of Autonomy and Moderation of the Sense of Entitlement
Authors: Gao Wen , Hou Yaxian , Nelson Larry J , Xu Yongqi , Meng Lingdan 
Published: May 2023

Abstract
This study examined the relationships between helicopter parenting and emerging adults' adjustment indices (school engagement, peer attachment, and stress) and the potential mediating role of autonomy and moderating role of the sense of entitlement in the relationships. Participants included 392 Chinese university students aged 18–23 (M = 18.83) who completed six questionnaires that assessed helicopter parenting, school engagement, peer attachment, stress, autonomy, and the sense of entitlement, respectively. The results showed that: (1) helicopter parenting significantly negatively predicted students' school engagement and peer attachment but positively predicted their stress; (2) autonomy mediated the relationships between helicopter parenting and students' adjustment indices; (3) students' sense of entitlement significantly negatively moderated the effect of helicopter parenting on their autonomy. These findings suggested that helicopter parenting can affect emerging adults' adjustment directly and indirectly by diminishing their autonomy in the collectivist culture. The sense of entitlement appeared to protect emerging adults from the detrimental consequences of helicopter parenting.
Predicting effects of non-point source Pollution emission control schemes Based on VMD-BiLSTM and MIKE21
Authors: Zhang Xianqi , Qi Yu , Liu Fang , LI Haiyang , Sun Shifeng 
Published: May 2023

Abstract
Controlling non-point source (NPS) pollution is crucial for implementing water environment management, and simulating the water quality response to NPS pollution emission control schemes is of great importance. Variational mode decomposition (VMD) can overcome endpoint effects and modal aliasing issues, effectively separating intrinsic mode components. Bidirectional long short-term memory (BiLSTM) can fully mine the information contained in time series and has good predictive performance. MIKE21, when coupled with the Ecolab module, can well simulate the diffusion process of NPS pollution. The Weihe River water environment prediction model was constructed using VMD-BiLSTM and MIKE21, with ammonia nitrogen (NH3-N), total phosphorus (TP), and chemical oxygen demand (COD) as pollution indicators, showing the water quality response of the Weihe River within a few years after the implementation of agricultural and urban NPS pollution emission control schemes. Among them, the COD concentration decreased by up to 71.3%, the NH3-N concentration decreased by up to 31.4%, and the TP concentration decreased by up to 43.1%. The results show that the water quality of the Weihe River can be significantly improved by controlling NPS pollution emission, and reducing agricultural NPS pollution emission is key to decreasing ammonia nitrogen and total phosphorus concentrations and improving water quality.
Regulation of LPS-Induced Inflammatory Responses in HMC3 Microglia by Nicotine and its Neuroprotective Effects
Authors: Qin Yu-Han , Luo Yan-Bo , Wang Hong-Juan , Tian Yu-Shan , Wu Xia-Qing , Chen Huan , Hou Hong-Wei , Hu Qing-Yuan 
Published: May 2023

Abstract
Microglia-mediated neuroimmune responses have been implicated in CNS injury and disease pathogenesis. The α7 nicotinic acetylcholine receptor is one of the receptors that microglia interact with in the surrounding microenvironment. Nicotine, a tobacco-specific alkaloid, can activate the α7 nicotinic acetylcholine receptor, leading to immune modulation. The PI3K protein plays a critical role in regulating immune homeostasis in microglia and is particularly valuable in managing neuroinflammation. Moreover, the α7 nicotinic acetylcholine receptor seems to have a cascading regulatory effect on the PI3K protein, and nicotine may influence microglial inflammatory activity through this pathway. This article aims to explore the modulatory effects of nicotine on neuroinflammation and its potential indirect neuroprotective effects using an in vitro microglial cell inflammation model. The study demonstrated that nicotine had a modest inhibitory effect on the LPS-induced inflammation model of HMC3 microglia. It also increased the release of neurotrophic factors and improved neuronal survival by modifying the immune environment. The action of nicotine is considered to be primarily through the activation of α7 nAChR on HMC3 cells, leading to an increase in PI3K protein phosphorylation. This study sheds light on the immunomodulatory role of nicotine in the nervous system and serves as a valuable reference for uncovering the medicinal potential of nicotine.
Evaluation of Postoperative Results After a Presurgical Optimisation Programme
Authors: Sánchez Francisco García , García Natalia Mudarra 
Published: May 2023

Abstract

Background
Presurgical optimisation programmes decrease the risk of postoperative complications, reduce hospital stays and speed up patient recovery. They usually involve a multidisciplinary team addressing physical, nutritional and psychosocial issues. The objective of this study was to assess the results of implementing a presurgical optimisation programme led by a liaison nurse in patients undergoing major surgery in a tertiary general hospital.
Methods
Observational, retrospective, descriptive, cross-sectional, comparative study based on the revision of patients’ health records undergoing major surgery between January 2019 and December 2022. Patients entering the presurgical optimisation programme (intervention group) were compared with patients receiving usual medical care (control group). The presurgical optimisation programme consisted of oral nutritional supplementation, physical exercise, strengthening of lung capacity and psychological and emotional support. Frequency (%) of surgery complications and use of healthcare resources (duration of hospitalisation, time spent in the intensive care unit (ICU), and readmission) at day 30 were recorded. Descriptive statistics were applied.
Results
211 patients (58.5% men, mean age: 65.76 years (SD: 11.5), 75.2%. non-smokers; mean body mass index (BMI): 28.32 (SD: 5.38); mean Nutritional Risk Score (NRS) 3.71 (SD: 1.35; oncology diagnosis: 88.6%) were included: 135 in the intervention group, and 76 in the control group. Average duration of the presurgical optimisation programme was 20 days (SD: 5). Frequency of postoperative complications was 25% (n = 33) in the intervention group and 52.6% (n = 40) in the control group (p < 0.001) [odds ratio (OR) = 3.4; 95% confidence interval (CI) (1.8; 6.2)]. 14.5% (n = 19) of patients in the intervention group and 34.2% (n = 26) in the control group had remote postoperative complications [OR = 3.1; 95% CI (1.6; 6.2)]. Patients in the intervention group spent fewer days in hospital [mean: 8.34 (SD: 6.70) vs 11.63 (SD: 10.63)], and there were fewer readmissions at 30 days (7.6% vs 19.7%) compared with the control group.
Conclusions
A presurgical optimisation programme led by a liaison nurse decreases the rate of immediate and late surgical complications and reduces hospital stay and readmissions in patients undergoing major surgery.
A Hybrid Node Localization Approach For Vehicular Adhoc Network Using Range Free Localization And Meta-heuristic Optimization Technique
Authors: sahu smitarani , Tripathy Biswajit , V Lakshmana Rao 
Published: May 2023

Abstract
The high mobility of vehicles causes dynamic changes in topology of the nodes present in vehicular ad hoc networks (VANETs) which can be considered as a type of mobile ad hoc network (MANET). The successful transmission of data packets in such a highly mobile, multi-hop, and infrastructure-free environment presents significant challenges and issues for the research community. Many studies have been conducted recently that focus on the different challenges and issues prevailing under different VANET scenarios. One of the important areas of research is the node localization. Localization of nodes or vehicles in VANET plays an essential role in many areas like intelligent transport system, tracking of vehicles, and prevention of vehicle collision. This paper aims at providing an efficient solution to the node localization problem by combining a range free technique and meta-heuristic optimization algorithm. The focus is on establishing an optimal node localization mechanism with less overhead suitable for VANET. For conducting the simulation and analysis with an aim to assess the efficiency of the proposed node location estimation mechanism the Intelligent Driver Model was used. The location of an unknown node is estimated using a hybrid approach by utilizing the localization and optimization strength of DV-Hop algorithm, a range-free location estimation technique and Particle Swarm Optimization (PSO), an optimization algorithm respectively.
Optimization and valorization of a clay and dune sand mixture for use in road construction
Authors: OUSLIMANE Noureddine , BAREBITA Hanane , BENSALAH Jaouad , TOUHAMI Mohamed EBN , BELFAQUIR Mustapha 
Published: May 2023

Abstract
Road construction plays an important role in the development of a country like Morocco. Most of the expansive soils found in the country are clay or marl, which have a "normal" state that is dry and dense. The problems created by these soils in the construction field are primarily due to soil swelling. For this reason, we have chosen to focus our work on the swelling behavior of clayey soils and evaluate the influence of adding dune sand in geotechnical studies to stabilize and modify the physico-chemical and mechanical characteristics at different percentages, considering oedometer tests.The treated and untreated soil samples are compacted at the optimum Proctor (WOpt and γDmax). The results of the compressibility tests show that the preconsolidation stress and consolidation of the treated samples are higher than those of the untreated samples. It has also been observed that dune sand reduces the compressibility index (Cc) and swelling index (Cg). Therefore, it can be said that stabilization with dune sand significantly improves the mechanical characteristics of the studied clay.The utilization of the studied materials presents a clean and cost-effective alternative in the field of road construction.
Preparation of a multifunctional and ultrasensitive Au@AgNPs-Van/PDMS film SERS substrate for rapid detection of foodborne pathogens in beef
Authors: Zhu Yaodi , Liu Shijie , Zhao Lijun , Wang Na , Li Mengya , Liang Dong , Zhao Gaiming , Liu Weijia , Sun Lingxia , Xu Lina , Li Miaoyun 
Published: May 2023

Abstract
We present a novel and super-sensitive vancomycin (Van) modified Au@AgNP self-assembly with polydimethylsiloxane (PDMS) (Au@AgNPs/Van-PDMS) film surface-enhanced Raman scattering (SERS) substrate for identification of foodborne pathogens in beef, without the need for in vitro bacterial culture. The results illustrated that the Au@AgNPs/Van-PDMS film exhibited high reproducibility and Raman enhancement effect (1.09×105). Clostridium perfringens, Bacillus subtilis and Staphylococcus aureus isolated from beef captured by Au@AgNPs/Van-PDMS film exhibited high reproducibility and significant differences. Principal component analysis score plots distinguished classes of foodborne pathogens, and the qualitative identification of linear discriminant analysis was correct at 100%. The detection limit of S. aureus in beef was as low as 3 CFU/mL. This method could provide an effective means and technical support for realizing the application of SERS technology for quick and highly sensitive detection of foodborne pathogens in complex environments.
Evaluation of Aitchisonia rosea for oxidative stress and its protective effect on H2O2 induced oxidative damage on DNA and RBCs
Authors: ALAJLANI MUAAZ , Rasool Shahid 
Published: May 2023

Abstract
Background
Aitchisonia rosea Hemsl. ex Aitch (Family Rubiaceae) has been used traditionally for the treatment of different diseases involving oxidation reactions. The current work was carried out to evaluate anti-oxidant potential of various organic fractions and essential oils from Aitchisonia rosea and to study their protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane.
Methodology
The in-vitro assays were performed with different concentrations of plant extract, its various fractions and essential oil. The essential oil was isolated, its GCMS analysis was performed and chemical constituents were identified in essential oil. Moreover, DPPH scavenging assay and ferric reducing anti-oxidant power assay was performed. Additionally, the DNA protection assay and RBC cellular membrane protection assay were performed.
Results
The main components identified by GCMS in essential oil of plant were germacrene (18.43%), carvacrol (12.80%) and linalool (2.67%). The results clearly indicated that methanol extract, ethyl acetate, n-butanol fractions and essential oil exhibited very promising radical scavenging effect and reducing power anti-oxidant activity. They also contained higher contents of phenolic compounds. The protective effect of plant on pBR322 DNA with H2O2 treatment showed that at concentration 1000 μg/ml, it converted the open circular damaged form of pBR322 DNA to super coiled safe form. The plant also protected RBC cellular membrane and thus safe for human use.
Conclusion
The results proved Aitchisonia rosea to be a valuable anti-oxidant that protects pBR322 DNA and RBC cellular membrane from free radical induced oxidative damage. Furthermore, it could be further develop as powerful and new anti-oxidant.
Bank Accounts for Minors: A Pathway to Financial Inclusion or a Dead-End?
Authors: Collins J. Michael , Larrimore Jeff , Urban Carly 
Published: May 2023

Abstract

This study estimates the effects of state laws that allow access to independently owned bank accounts without a custodian. In states where minors can own accounts, youth aged 16 through 19 are more likely to be banked, although by age 24 those young adults are banked at similar rates to teens who grew up in states that do not allow minors to own accounts independently. However, young adults who had access to independently owned accounts at teens are thenmorelikely to use high-cost non-bank financial services, particularly check-cashing services. Young adults who had access to non-custodial accounts as teens also show lower credit scores and more loan delinquencies at ages 21 through 24. While state banking policies can increase financial inclusion for teenagers, minors with bank accounts face frictions transitioning to adult accounts. Since minor accounts require opening a new bank account, this transition process appears to drive young people with non-custodial minor-owned accounts to use more alternative, non-bank financial services. JEL Codes: D14, D18, G18, G21, G28
Potential distribution of Rice Thrip (S.biformis) in India under climate change
Authors: Pushpalatha Raji , Gangadharan Byju , Roshni Thendiyath , Kutty Govindan 
Published: May 2023

Abstract
India’s economy is agro-based economy and in which rice is the major crop grown in the country. India is also one among the global leaders in the production of rice and is accounted for approximately 10% of nation’s economy. Present and future changes in the climate may challenge the crop production as the pest pressure in agriculture varies significantly with the elevated temperatures. The rice thrip (S.biformis) is the most challenging pest of rice and often causes yield reduction and significant economic loss. The climate change leads to variations in meteorological parameters, and it apparently affects the developmental rates and population dynamics of rice thrip. Monitoring its geographical distribution based on the climatic conditions can minimize crop yield losses. Therefore, the present study focused to quantify the temperature changes and eventually the population dynamics of rice thrip in India using projections from Hadgem3-GC31 and MPI-ESMI-2 under three emission scenarios (SSP126, SSP245 and SSP585) for the year 2050. The probability distribution from the MaxEnt species distribution model indicates the southern and north-eastern regions of India will be highly affected by rice thrip in 2050, and a total of 391 districts will be highly affected (locations where the predicted probability by the model is greater than 0.8) for the SSP126. The number of districts which will be highly affected by rice thrip for SSP245 and SSP585 are 418 and 435 respectively. The analysis shows that the most influencing climatic parameter for the geographical distribution of rice thrip is Tmax (quadratic relation) followed by bioclimatic variable and Tmin (positive relation). This suggests the regions with possibility to increase the maximum temperature will be highly suitable for its growth and distribution. Quantifying the dynamic population of rice thrip under climate change can facilitate and strategize integrated pest management practices to a sustainable food production by minimizing the risks.
A holistic analysis of photosynthetic acclimation to shade in C4 grass (Cynodon dactylon (L.) Pers.)
Authors: Wang Guangyang , Mao Jinyan , Ji Mingxia , Wang Wei , Fu Jinmin 
Published: May 2023

Abstract
Background: Lack of light in shady environment is the key factor affecting the growth and development of turf plants. However, it is shade avoidance rather than shade tolerance that has received more attention in past decades. In this study, we investigated the photosynthetic metabolisms of Bermuda grass exposed to deepening shade, aiming to provide a holistic perspective for understanding the shade acclimation strategies of C4 turfgrass.
Results: The adjustments of pigment-proteins, photosynthetic electron transport and its coupling of carbon and nitrogen assimilation, ROS-scavenging enzyme activity in shade surroundings were detected. Mild shade enriched Chl b and LHC transcripts, while Chl a, carotenoids and photosynthetic electron transfer beyond QA- (ET0/RC, φE0, Ψ0) were enhanced by severe shade. In addition, differential impacts of shade on leaf and root were shown. Soluble sugar deficiency varied between the two, due shade reduced SPS, SUT1 while up-regulated BAM. Besides, Shading weakened the transcriptional level of genes involving in nitrogen assimilation (e.g. NR) and SOD, POD, CAT enzyme activities in leaf, but improved them in root.
Conclusions: As the shade deepened, extensive changes had taken place in light energy conversion and photosynthetic metabolism process along the axis of electron transport chain. This study provided a theoretical basis for the photosynthetic acclimation of C4 grass to shade tolerance.
Prognosis and tailored treatment prediction based on key genes between polycystic ovary syndrome and uterine corpus endometrial carcinoma
Authors: Shao Shuyi , Lv Qiaoying , Hu Shuhui , Lu Zhiying , Xia Hexia , Zhao Huanqiang , Zhang Ying , Wang Zhiheng 
Published: May 2023

Abstract

Background Polycystic ovary syndrome (PCOS) is one of the most common risk factors for the development of uterine corpus endometrial carcinoma (UCEC). Despite mounting evidence suggesting that PCOS was strongly associated with the adverse prognosis of UCEC, prognosis prediction and treatment determination remain exceedingly challenging. Results In this study, we constructed a prognostic signature for UCEC and predicted potential therapeutic agents for UCEC patients with high risk score. First, we identified the key genes between PCOS and UCEC, and explored the characteristics with multiple algorithms. Next, the bootstrap method divided samples into TCGA training and testing cohorts. Based on 25 different models, we selected the best and established a twelve-gene signature for UCEC in the training cohort. Then the signature was validated via the TCGA testing and the entire TCGA-UCEC cohorts. Univariate and multivariate analysis verified the independence of the signature. A nomogram was subsequently established to provide a quantitative tool for personalized medicine. Moreover, hallmark pathways and genomic variation analysis were used to explore the mechanism engaged in the unfavourable prognosis. Finally, apicidin has been identified to have potential therapeutic implications in the high-risk UCEC patients. Conclusions A twelve-gene signature that involved in the prognostic significance of UCEC has been constructed. Our result may shed light on personalized prognostication and tailored therapy strategies in UCEC.