bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early detection of neck lymph node metastases in breast cancer patients: the role of ultrasound and fine needle biopsy
Authors: Rebol Janez , Balon Peter , Kokol Peter , Lanišnik Boštjan , Takač Iztok , Dovnik Andraž , Fokter Dovnik Nina , Sobočan Monika , Arko Darja 
Published: February 2023

Purpose: To analyze the distribution and pattern of neck metastasis in breast cancer (BC) patients.
Methods: The clinicopathological characteristics of 41 patients with BC and confirmed neck metastasis (NM) treated at our institution between 2010 and 2016 were retrospectively analyzed by reviewing medical records. The diagnosis of NM was confirmed by fine needle aspiration cytology, and node localization was classified into six levels according to Robbins' classification. Statistical analysis was performed using descriptive statistics, Pearson’s correlation and multidimensional correspondence analysis. All statistical analyses were performed using SPSS.
Results: At the time of neck ultrasonography, 34 (85%) patients had developed distant metastases, 38% of the patients were asymptomatic, and 17% had no palpable nodes. The average time from BC diagnosis to the development of NM was 5.8 years (range, 0–26 years). Lymph node metastasis occurred at level V in 53.7% of patients and level IV in 19.5% of patients. Two-level involvement occurred in 9.8% and one-level involvement in 75% of patients. There were significant correlations (p < 0.01) between patient age andtime from diagnosis to development of NM, age and stage of the disease, and stage and appearance of conglomerates.
Conclusion: The most common site of NM from BC was next to the supraclavicular fossa, although they occurred at other levels. Ultrasonography combined with fine needle aspiration cytology is effective for the detection of early occult metastatic lymph nodes.
Cumulative pregnancy and live birth rates following intrauterine insemination and in vitro fertilization in couples with unexplained infertility
Authors: Kozar Nejc , Kovačič Borut , Reljič Milan , Kovač Vilma 
Published: February 2023

Purpose: There are multiple options for the treatment of unexplained infertility. Two of the most commonly used treatments are intrauterine insemination (IUI) and in vitro fertilization (IVF). The aim of our research was to analyze and compare the success rates of IUI and IVF procedures in the treatment of unexplained infertility.
Methods: This was a retrospective study including 914 cycles of IUI performed for 355 couples, and 302 IVF cycles performed for 161 couples. All cases involved unexplained infertility and were treated in our department between 2012 and 2014. We analyzed differences in pregnancy, live birth rate, multiple pregnancy rate, and predictive factors for IUI.
Results:There was a significant difference between IUI and IVF in terms of cumulative pregnancy and live birth rates after 4 cycles (22.0% vs. 71.8%; p < 0.001 for clinical pregnancy rates and 16.1% vs. 64.8%for live birth rate). Differences between the two techniques in terms of twin live birth rates were not significant (16.5% for IUI vs. 17.6% for IVF; p=0.936). Using logistic regression, we found that the duration of infertility, total sperm count, and the type of stimulation, were significant predictive factors for IUI (p = 0.014, p = 0.036 and p = 0.046, respectively).
Conclusion: As expected, according to pregnancy rate, IVF is a better option for the treatment of idiopathic infertility than IUI. However, IUI should not be underestimated since it offers reasonable success rates with significantly less invasiveness. To improve the outcome of treatment for unexplained infertility, we suggest that treatment methods should be chosen with respect to predictive factors.
Preoperative antibiotic prophylaxis in a single tertiary hospital in Slovenia—the role of education in recommendation compliance
Authors: Žnidarič Matej , Vogrin Matjaž , Moličnik Andrej , Mujezinović Faris , Kavčič Niko , Gorišek Miksić Nina 
Published: February 2023

Purpose: The aim of the present study was to evaluate the impact of an educational intervention package on perioperative antimicrobial prophylaxis (PAP) prescription practice in three elective procedures—total hip arthroplasty (THA), caesarean section (CS), and radical prostatectomy (RP)—in a single tertiary care hospital in Slovenia.
Methods: An interventional study was performed to evaluate the impact of an educational intervention package on PAP compliance. PAP prescription practices for three elective types of surgery (THA, CS, and RP) were observed. Thirty operative reports for each type of surgical procedure were evaluated according to indication, timing of preoperative prophylaxis administration, antibiotic selection and dosage, and total prophylaxis duration. This was followed by an educational intervention package that included a discussion with department leaders led by an infectious disease specialist and an educational seminar and discussion for surgeons, supplemented by PAP recommendations provided as pocket reminders. Then, the compliance with PAP recommendations for the same types of procedures performed in the post-interventional period (3–6 months after the intervention) was evaluated again.
Results: Complete pre-interventional compliance with local guidelines was observed in 67%, 70%, and 3.3% of THA, CS, and RP cases, respectively. A major deviation from PAP recommendations was observed in the timing of preoperative PAP administration before surgery and in the total PAP duration A deviation from recommendations for RP, which is a major surgical procedure, was observed as a longer postoperative PAP duration compared to the intraoperative course. In the post-interventional period, an improvement in total compliance with PAP recommendations was observed in 80.0%, 90.0%, and 50.0% of THR, CS, and RP procedures, respectively.
Conclusion: Our study revealed an improvement in adherence to PAP recommendations after an educational intervention package for selected procedures at the University Medical Centre Maribor. This simple intervention can have an important impact on patient care quality by reducing antimicrobial medication use, resistance development, and treatment cost.
Child and adolescent mental health services during the COVID-19 epidemic in Slovenia: Comparison with other European countries
Authors: Gregorič Kumperščak Hojka , Podlesnik Peršak Ivan 
Published: February 2023

Purpose: To evaluate the impact of the COVID-19 epidemic on child and adolescent mental health services (CHAMS) during the first and second epidemic wave.
Methods: Members of the Slovenian Association for Child and Adolescent Psychiatry (n=66) were invited to participate in the study. The survey involved two semi-structured questionnaires on CHAMS and clinical and organizational issues with respect to the first and second COVID-19 waves. The findings were compared with similar studies conducted in other European countries.
Results: Eighteen members fulfilled the first and seven the second questioner. Thirty-three percent of respondents reported that their CHAMS colleagues were assigned to the COVID-19 wards during the first and 43% in the second wave. The CHAMS were more affected by the public health measures for COVID-19 during the first wave. During the first wave, half of the respondents experienced worsening anxiety disorders, while an increase in all mental disorders was reported during the second wave.
Conclusion: A concerning finding of this study was limited access to CHAMS as a result of public health measures, especially during the first wave. But the provision of services in Slovenia was not as severely limited as elsewhere in Europe. CHAMS in Slovenia were able to provide better employee safety measures in terms of COVID-19 infections compared to other European countries. CHAMS employees in Slovenia were more frequently transferred to COVID-19 wards compared to their European colleagues, despite the fact that they were faced with increasing numbers of children and adolescents with mental disorders.
The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings
Authors: Maver Uroš , Maver Tina 
Published: February 2023

Purpose: Wound dressings are one of the most commonly used products in wound care. Nowadays, various wound dressings are developed containing different active ingredients, often drugs from different pharmacodynamic groups. Considering the variable and changing environment in each wound type, it is important that the experimental design for evaluating the in vitro drug release of such materials takes into account these different conditions.
Methods: For this purpose, Franz diffusion cells for in vitro drug release testing are the method of choice, as they are not only able to simulate different conditions during wound healing but also allow for a certain degree of possible changes in the experimental design (e.g., diffusion cell size).
Results: In this study, we aimed to compare two Franz diffusion cells with different volumes of receptor medium to evaluate naproxen release from an alginate-based model wound dressing. We confirmed that the volume of the receptor medium not only affects the amount of drug released in the selected time but also significantly influences the release mechanism.
Conclusion: The different volumes of the Franz diffusion cell receptor compartments allow the simulation of wounds with a higher and a lower degree of exudation. The experimental design for in vitro drug release testing based on Franz diffusion cells must be based on a thorough consideration of the targeted wound type for which the dressings are being developed.
A prospective study of the correlation between infection of the uterine cervix and secondary bleeding after large loop excision of the transformation zone (LLETZ)
Authors: Arko Darja , Dovnik Andraž , Fokter Nina , Takač Iztok 
Published: February 2023

Purpose: A prospective study was undertaken to evaluate the role of genital pathogens in postoperative bleeding necessitating secondary intervention after large loop excision of the transformation zone (LLETZ) of the uterine cervix.
Methods: A total of 1419 patients with cervical intraepithelial neoplasia (CIN) who underwent LLETZ were included in the study. To determine the presence of genital pathogens, cervical swabs were collected before the procedure. Postoperatively, patients were followed up for bleeding necessitating secondary interventions.
Results: Among 1419 patients, genital pathogens were present in 714 (50.3%) cases and absent in 705 (49.7%) cases. The most frequently isolated groups of microorganisms were group-B β-haemolytic streptococci, α-haemolytic streptococci, Enterococcus sp. and coliforms. Secondary procedures due to severe bleeding were required in 48 (6.8%) patients without and in 63 (8.8%) patients with genital pathogens, but this difference was not significant (chi-square test = 1.72; P>0.05).
Conclusion: These data suggest that genital pathogens are very common in patients with CIN and are not an important cause of postoperative bleeding necessitating secondary intervention after LLETZ.
One month prevalence of self–reported musculoskeletal pain syndromes and correlates
Authors: Klemenc–Ketis Zalika , Kersnik Janko 
Published: February 2023

Purpose: The aim of this study was to determine the prevalence of 1 month musculoskeletal pain symptoms in a representative sample of the Slovenian general population and to determine factors associated with the symptoms.
Methods: We performed an observational cross–sectional study in June 2011 in a representative sample of 1,002 randomly selected Slovenian citizens, stratified according to gender and age, using a computer–assisted telephone interview method.
Results: At least 1 day in the past month, 559 participants (55.7%) experienced musculoskeletal symptoms; 226 participants (22.5%) experienced musculoskeletal symptoms everyday of the past month. Older age, female gender, lower education, lower monthly income, seeking lay advice, seeking medical advice, self–treatment, self–reported mobility problems, problems with self–care, pain, difficulties in daily activities, anxiety and/or depression, employment, retired, and a chronic disease were associated with the presence of musculoskeletal pain during the entire past month. When compared to the remainder of the sample, subjects with musculoskeletal pain had more often mobility problems and more often reported the presence of pain.
Conclusion: Musculoskeletal symptoms are very common in the Slovenian general population and present a significant public health problem.
Morphometrical analysis of the p53 tissue marker in prostatic adenocarcinoma and its relationship to Gleason score and PSA level
Authors: Munda Miha , Dariš Barbara , Hajdinjak Tine , Kavalar Rajko , Štiblar Martinčič Draga 
Published: February 2023

Purpose: Prostate cancer is one of the most common malignancies worldwide. The possible prognostic value of tissue markers, such as p53, may give a better understanding of this disease, improve staging accuracy, and help in choosing optimal treatment. In this study, we examined p53 expression and its correlation with Gleason score, prostate–specific antigen (PSA) levels, and patient age in a Slovenian population.
Methods: This retrospective pilot study included 25 radical prostatectomy patients. The immunohistochemical expression of p53 was determined and expressed as a p53 index. In addition, correlations between p53 index, Gleason score before and after prostatectomy, PSA level, and patient age were statistically evaluated.
Results: The p53 tissue marker was unevenly distributed in prostate cancer independently of local Gleason pattern; however, its expression correlated with Gleason score after prostatectomy and showed borderline correlation with PSA. There were also statistically significant correlations between Gleason score before and after prostatectomy, PSA level, and patient age.
Conclusions: Despite the low number of cases presented in this study, our results demonstrate that p53 may have predictive value in prostate cancer. Thus, p53 is a promising tissue marker that can be used as an additional diagnostic parameter.
Surgical management of traumatic spondylolisthesis of the axis
Authors: Movrin Igor , Četnik Andrej 
Published: February 2023

Purpose: AThe optimal treatment modality for traumatic spondylolisthesis (TSA) of the axis (second cervical vertebra) remains controversial. Many conservative and anterior techniques have been used to treat these injuries.
Case report: We describe a 29– year–old woman who presented to the emergency department with severe neck pain after falling down a flight of stairs. Cervical plain radiographs and computer tomography (CT) scan demonstrated a major C2 body anterior dislocation with bilateral C2 pedicle fractures. A Crutchfield extension was applied, with four kilograms of traction initially, with the neck in slight extension. After two hours of traction, plain radiographs showed near–anatomical reduction. The same day the patient underwent an anterior C2/C3 discectomy and autologous bone fusion with a cervical spine locking plate (CSLP). There were no neurological deficits postoperatively and the patient was asymptomatic. She was discharged home on postoperative day eight with a Philadelphia collar for 6 weeks.
Conclusion: Anterior C2/C3 discectomy and fusion may be feasible and safe in unstable TSA, with the benefit of high primary stability, anatomical reduction, a high union rate, and favorable clinical outcome
Carbon monoxide intoxication: A report of two cases
Authors: Hajdinjak Emina , Markota Andrej , Strdin Košir Alenka , Kirbiš Simona 
Published: February 2023

Purpose: Here, we describe the application of non–invasive carbon monoxide monitoring for two patients with suspected carbon monoxide intoxication.
Case reports: Since signs and symptoms are non–specific, carbon monoxide intoxication is often diagnosed only after other causes of unconsciousness have been excluded. This paper presents two cases of carbon monoxide and alcohol intoxication. From the information available (both patients were found in open spaces, unconscious, with no external signs of injury), it was impossible to infer carbon monoxide intoxication. In both cases, carbon monoxide intoxication was detected by noninvasive carbon monoxide monitoring in accordance with the ABCDE approach for the immediate assessment and treatment of critically ill patients. Other findings (blood pressure, blood sugar, etc.) did not explain the state of either patient. Both patients received oxygen therapy before the determination of carbon monoxide in the arterial blood and both were discharged after 2 days of treatment without short–term neurological sequelae. The source of carbon monoxide in each case was exposure to smoke and automobile exhaust, respectively, with concurrent alcohol intoxication.
Conclusion: The use of devices that enable the rapid and noninvasive detection of carbon monoxide can facilitate diagnosis of carbon monoxide intoxication.
Peningkatan Daya Tarik Wisata Megalitikum Melalui Konservasi dan Preservasi Situs Duplang Berbasis Masyarakat di Kabupaten Jember
Authors: Hamindhani Galuh Ajeng , Koesoemawati Dewi Junita , Revana Dano Quinta 
Published: February 2023

Situs Duplang di Desa Kamal merupakan situs utama di Kabupaten Jember dan sebagai wisata budaya di Kecamatan Arjasa, yang memiliki potensi sebagai tempat wisata, sumber pendidikan, dan sebagai tempat penelitian. Situs Duplang sebagai bukti peradaban manusia harus terlestarikan agar dapat bertahan dalam jangka waktu yang lama, sehingga keterlibatan masyarakat dan pemerintah sangat diperlukan dalam upaya tersebut karena masih belum ada pengelolaan secara profesional sebagai kawasan wisata sejarah dan edukasi. Oleh karena itu perlunya melakukan upaya konservasi dan preservasi berbasis masyarakat, dimana terdapat keterlibatan masyarakat dalam melindungi dan meningkatkan daya tarik wisata Situs Duplang dengan dorongan dan bantuan dari pemerintah. Metode yang digunakan dalam penelitian ini yaitu deskriptif, skoring objek cagar budaya, dan analisa SWOT. Arahan atau strategi pelestarian yang harus dilakukan ada lima yaitu meningkatkan pengetahuan masyarakat terkait situs dan upaya konservasi-preservasi, melestarikan sosio kultur atau budaya masyarakat lokal, meningkatkan perlindungan Situs Duplang, mengembangkan kawasan wisata megalitikum dengan museum terbuka, serta meningkatkan promosi pada Situs Duplang.
Partisipasi Masyarakat Dalam Pengembangan Pariwisata Pantai Watu Pecak Kabupaten Lumajang
Authors: Marcella Priska Dwi , Sukmawati Sri , Aji Rendra Suprobo 
Published: February 2023

Pada Rencana Penetapan Kawasan Strategis, dalam penetapan strategis pengembangan kawasan perekonomian jalur selatan terdapat wisata pantai. Pantai Watu Pecak memang menawarkan banyak keindahan dan keunikan tersendiri. Partisipasi masyarakat Desa Selok Awar–Awar sangat dibutuhkan dalam meningkatkan jumlah wisatawan di Pantai Watu Pecak. Tujuan dilakukan penelitian adalah untuk mengidentifikasi faktor yang mempengaruhi pengembangan pariwisata Pantai Watu Pecak dalam mendukung sektor kepariwisataan di Kabupaten Lumajang, untuk mengetahui bentuk partisipasi yang dilakukan masyarakat dalam pengembangan Pantai Watu Pecak dan merumuskan strategi pengembangan pariwisata Pantai Watu Pecak di Kabupaten Lumajang. Metode analisis yang digunakan dalam menentukan faktor-faktor adalah Delphi, untuk penentuan bentuk partisipasi masyarakat menggunakan metode Deskriptif, sedangkan dalam penentuan strategi pengembangan wisata dilakukan dengan menggunakan metode SWOT. Berdasarkan hasil analisa, diketahui bahwa faktor penentu yang dapat mempengaruhi pengembangan wisata Pantai Watu Pecak ada 5 faktor, yakni: Atraksi, Aksesibilitas, Fasilitas, Pelayanan Tambahan dan Lingkungan. Bentuk partisipasi terbanyak yang diberikan oleh masyarakat Desa Selok Awar–Awar untuk pengembangan wisata Pantai Watu Pecak yaitu partisipasi buah pikiran dan partisipasi tenaga, dengan tingkat partisipasi masyarakat berada pada tingkat consultation, sehingga tergolong dalam kategori Tokenism (partisipasi semu). Selain itu hasil dari analisis SWOT diketahui dalam penetapan Strategi Pengambangan Kawasan Pariwsata Pantai Watu Pecak berada pada kuadran 1.
SIFAT-SIFAT MODUL SOFT
Authors: Mahmudah Ridha , Hijriati Na'imah 
Published: February 2023

Suatu himpunan tak kosong disebut modul atas suatu ring dengan elemen satuan jika himpunan tersebut merupakan grup komutatif yang tertutup terhadap perkalian skalar yang memenuhi beberapa aksioma. Kombinasi dari konsep modul dengan himpunan soft menghasilkan modul soft. Konsep ini diperkenalkan oleh Sun, Zhang dan Lui pada tahun 2008. Himpunan soft atas suatu himpunan semesta adalah pasangan berurut dari fungsi dan himpunan parameter. Fungsi dari himpunan soft ini adalah pemetaaan dari himpunan parameter ke himpunan kuasa semesta. Jika himpunan semesta dari himpunan soft ini merupakan suatu modul dan image dari fungsi yang membentuk himpunan soft merupakan submodul, maka himpunan soft ini disebut modul soft. Penelitian ini bertujuan untuk membuktikan hasil operasi irisan, operasi gabungan, jumlah langsung dan hasilkali dari beberapa modul soft merupakan modul soft dan hasil dari homomorfisma modul yang dikomposisikan dengan modul soft merupakan modul soft. Penelitian ini diawali dengan membuktikan sifat operasi irisan, operasi gabungan, jumlah langsung, dan hasilkali pada modul soft. Kemudian, penelitian ini membuktikan sifat pada submodul soft. Selanjutnya, berdasarkan sifat dari submodul soft, dibuktikan sifat modul soft terkait dengan homomorfisma modul. Kesimpulan dari penelitian ini adalah hasil dari operasi irisan, gabungan, jumlah langsung dan hasilkali dari beberapa modul soft merupakan modul soft. Lebih lanjut, penelitian ini diperoleh juga bahwa hasil dari homomorfisma modul yang dikomposisikan dengan modul soft menghasilkan modul soft.
Pengaruh Kualitas Pelayanan E-Channel dan Kualitas Pelayanan Tatap Muka Terhadap Kepuasan dan Loyalitas Penabung (Studi Pada Bank Kalsel di Kabupaten Barito Kuala)
Authors: Deni Deni , Ghalib Saladin 
Published: February 2023

The research method used is positivistic, descriptive/explanatory causality, data collection using a survey method with a sample size of 648 Simpeda General savers and Simpeda KPE savers selected by multistage proportional convenience sampling technique. The google form questionnaire was distributed via whatsapp group and 400 copies were printed. The 676 copies of the questionnaire that returned after being verified were selected as many as 648 copies according to the initial plan. Data analysis using path analysis technique, data calculation using SPSS Version 25 application.The results of the study found that the quality of e-channel services had a significant positive effect on both satisfaction and customer loyalty. The quality of face-to-face services has a significant positive effect on both satisfaction and customer loyalty. Satisfaction has a significant positive effect on the loyalty of savers. Satisfaction mediates the significant positive effect of E-Channel service quality on saver loyalty. Satisfaction also mediates the positive effect of face-to- face service quality on saver loyalty. The results of this study are useful as a basis for managing decisions to increase saver loyalty through efforts to improve service quality (e-channel and face-to-face) in the context of increasing saver satisfaction at this bank. Keywords: Loyalty, Satisfaction, Service Quality, e-channel, face-to-face, savers