bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular epidemiology of non-falciparum Plasmodium infestations in different areas of the Ivory Coast
Authors: Miezan Assohoun Jean Sebastien , Gnagne Akpa Paterne , Bedia-Tanoh Akoua Valérie , Kone Estelle , Konate-Toure Abibatou , Angora Kpongbo Etienne , Bosson-Vanga Abo Henriette , Kassi Kondo Fulgence , Kiki-Barro Pulchérie Christiane Michelle , Djohan Vincent , Menan Eby Ignace Hervé , Yavo William 
Published: January 2023

Abstract
Malaria is a major public health problem, particularly in the tropical regions of America, Africa and Asia. Plasmodium falciparum is not only the most widespread but also the most deadly species. The share of Plasmodium infestations caused by the other species (P. ovale and P. malariae) is clearly underestimated. General objective was to determine the molecular epidemiology of plasmodial infestations due to P. malariae and P. ovale in Côte d'Ivoire. This is a cross-sectional study which took place from February to March 2021 at the Centre de Recherche et de Lutte contre le Paludisme (CRLP) of the Institut National de Santé Publique (INSP). The collection of samples took place from May 2015 to April in different malaria epidemiological facies in Côte d'Ivoire. Analysis of the collected samples was performed. In each patient, we collected blood by venipuncture at the elbow on EDTA tubes. These samples were used to make confetti on Wathman paper for the molecular diagnosis of malaria. Molecular diagnosis as well as differential diagnosis of plasmodial species using the nested PCR technique. A total of 360 samples were tested with a success rate of 72.5% (261 out of 360). The sex ratio was 0.84. The overall plasmodic index was 72.5%. The specific index was 77.4%; 1.5% and 0% for P. falciparum, P. malariae and P. ovale in mono-infestation, respectively. There was also 15% P. falciparum and P. malariae co-infestation, 3.4% P. falciparum and P. ovale co-infestation and 2.3% P. falciparum, P. malariae and P. ovale triple-infestation. After exclusion of P. falciparum monoinfestation cases, 59 samples were finally retained to evaluate the molecular epidemiology of non-falciparum Plasmodium infestations. Typing of Plasmodium ovale subspecies showed a clear predominance of Plasmodium ovale curtisi (81.2% of cases). Plasmodium falciparum remains the most prevalent malaria species in Côte d'Ivoire, but P. malariae and P. ovale are endemic at a low rate. The elimination of malaria requires a better understanding of the specific epidemiological characteristics of P. malariae and P. ovale with a particular emphasis on the identification of asymptomatic carriers.
DEA based fuzzy portfolio evaluation models integrated with TOPSIS techniques to rank the efficient Portfolios under different risk indicators
Authors: Aggarwal Abha , Gupta Anjana , Verma Rajkumar , Kumari Reenu 
Published: January 2023

Abstract

Data Envelopment Analysis models estimates the relative efficiency of a group of identical Decision-Making Units (DMUs) with multiple inputs and outputs. Since the rank of all efficient DMUs in DEA is one, thus there is no other method to distinguish their performance. Now, as all the efficient DMUs may be considered an alternative, the ranking of all efficient units is required. Here, we made an attempt to assess the portfolios from two perspectives: efficiency and performance. Accordingly, the portfolios have been ranked through a two-stage process using DEA-based fuzzy portfolio estimation models in stage 1 and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method in stage 2. To evaluate the portfolio efficiency in a fuzzy environment, two types of portfolios are considered, having possibilistic mean return as output and possibilistic variance and possibilistic semi-variance as input criteria, respectively. As an output variable can take positive as well as negative values, the Range Directional Measure (RDM) model of DEA has been extended to fuzzy environment and used to rank all the portfolios as per their efficiency score. By utilizing the properties and advantages of both methods, this paper proposed a hybrid approach (DEA-TOPSIS method) which provides the complete ranking of all efficient fuzzy portfolios. Detailed numerical illustrations are presented here to authenticate the proposed approach, and the obtained results are compared with other existing DEA methods that validate the accuracy and feasibility of the proposed technique.
Planning of maxillofacial reconstruction with free revascularized fbular autograft: past, present, and future: literary review
Authors: Saprina O. A. , Shpitser I. M. 
Published: January 2023

The purpose of the study was to search for data on the evolution of virtual planning of reconstruction with a fibular graft.Material and Methods. A literature search was carried out in Scopus, RSCI databases in the time interval from 1975 to 2021 using the keywords: “computer”, “surgery”, “facial”, “microsurgery”, “fibula”, “implant”, “fibular flap”, “planning”.Results. Various planning techniques with a description of technical features and estimation of advantages and disadvantages as well as methods of minimizing errors and reducing the time spent on the modeling with an improvement in functional and aesthetic outcomes were discussed. Surgical workflows of robot-assisted osteotomies of a fibular graft were described. Complications, difficulties, and the financial aspect of fibula free flap maxillofacial reconstructions were assessed.Conclusion. Virtual planning of microsurgical reconstructions using a fibular graft reduces operating time. The accuracy of graft fixation is increased and diastases between the osteotomy lines as well as between the native jaw and the graft are decreased. Planning allows surgeons to improve symmetry or keep it in the original form, thus affecting the aesthetic aspect and emotional state of the patient. Virtual planning requires certain financial costs, but the wide range of benefits should convince the professionals to use it as often as possible.
Clinical case of pathological complete response of gastric cancer after one cycle of neoadjuvant chemotherapy with fot regimen
Authors: Skoropad V. Yu. , Kudriavtsev D. D. , Shitareva V. N. , Zhavoronkovа E. S. 
Published: January 2023

Background. Gastric cancer is the 5th most common cancer and the 3rd leading cause of cancer death globally. In Russia, gastric cancer is the 2-nd leading cause of death (10.7 %). Surgery in combination with perioperative/adjuvant chemotherapy is the standard treatment for locally advanced gastric cancer. Four cycles of neoadjuvant chemotherapy and 4 cycles of adjuvant chemotherapy with the FLOT regimen is the most widely used treatment modality. The basis for the widespread use of this chemotherapy regimen was the results of a large randomized FLOT4 trial, according to which the perioperative FLOT regimen showed greater efficacy compared to the ECF regimen.The aim of the study was to demonstrate the feasibility of achieving patholopgical complete response and long-term remission after one course of neoadjuvant chemotherapy with FLOT regimen in a patient with locally advanced gastric cancer.Case description. A 69-year-old patient presented to A. Tsyb Medical Radiological Research Centre with complaints of general weakness, moderate epigastric pain for 2 months. The examination revealed stage T3N0M0 IIA gastric cancer. The patient received one cycle of neoadjuvant chemotherapy with the FLOT regimen. Given the fact, that the patient developed massive bleeding from the tumor, it was decided to stop neoadjuvant treatment. Subtotal gastrectomy with D2 lymph node dissection was performed. Histological examination of the surgical specimen revealed pathological complete response (grade 1a according to the classification of K.Becker et al., 2003). The patient is alive with no signs of disease progression for more than 36 months after starting the treatment.Conclusion. This clinical case demonstrated personalized approach to the treatment of patients with locally advanced gastric cancer. Pathological complete response was achieved after one cycle of neoadjuvant chemotherapy.
Short-term outcomes of neoadjuvant chemotherapy in colorectal cancer patients with isolated liver metastasis
Authors: Dobrodeev A. Yu. , Kostromitsky D. N. , Tarasova A. S. , Afanasyev S. G. , Babyshkina N. N. , Ponomaryeva A. A. , Ermolenko R. V. , Frolova I. G. , Cheremisina O. V. 
Published: January 2023

The purpose of the study was to assess the short-term effcacy and tolerability of neoadjuvant chemotherapy (NAC) in colorectal cancer (CRC) patients with isolated liver metastasis.Material and Methods. Since 2020, a pilot study including 23 CRC patients with liver metastasis has been conducted at the Abdominal Cancer Department of the Cancer Research Institute (Tomsk, Russia). The combined treatment modality included 3 cycles of NAC according to FOLFOXIRI + cetuximab (20 patients with wtKRAS) and FOLFOXIRI + bevacizumab (3 patients with mtKRAS) regimens followed by simultaneous laparoscopic colorectal resection and open liver resection.Results. For liver metastases, the objective response rate reached 100 % (complete response: 8.7 %, partial response: 91.3 %). For the primary tumor, the objective response rate was 100 % (partial response). The overall NAC toxicity rate was 53.6 %. The major I–II grade toxicities included nausea/vomiting (27.5 %), polyneuropathy (10.1 %), skin reaction (10.1 %), hepatotoxicity (5.8 %), and corresponded to I–II grade. R0 resection was performed in all patients. Postoperative complications were observed in 19 (82.6 %) patients; of them 18 (78.3 %) had a febrile temperature (grade 1, according to the Clavien–Dindo classifcation) due to the use of bipolar coagulation during liver surgery, and 1 (4.4 %) patient developed a biliary fstula (3 A/B grade according to Clavien–Dindo). No postoperative death occurred. For liver metastasis, pathological complete response rate was 4.4 % (TRG1 according to Mandard); for the primary tumor, in most cases was TRG 3 – 87 %.Conclusion. Combined treatment modality, including NAC with FOLFOXIRI regimen and targeted therapy for CRC with liver metastases, is well tolerated, has a signifcant damaging effect on the tumor, and does not affect the course of the postoperative period. Further studies are required to assess the long-term treatment outcomes.
Transhiatal laparoscopic enucleation of lower thoracic esophageal leiomyoma
Authors: Kamalov A. K. , Ryabov A. B. , Khomyakov V. M. , Volchenko N. N. , Kolobaev I. V. , Kostrygin A. K. , Sobolev D. D. , Utkina A. B. , Aksenov S. A. , Makurina M. P. 
Published: January 2023

The purpose of the study. Mesenchymal tumors of the esophagus comprise 2 % of all esophageal tumors. Leiomyosarcoma is the most common mesenchymal tumor in the esophagus (up to 80 %). It is located in the lower third of the esophagus. The main treatment modality of leiomyosarcoma is surgery. Due to the low frequency of occurrence, there are no unified approaches to the choice of surgical volume and access. Minimally invasive techniques have advantages over open approaches. However, final treatment approach depends on many factors: localization and location of the tumor around the circumference of the esophagus, as well as size. Endoscopic resection is feasible for small tumors with an intramural growth. In case of large leiomyomas, Lewis operation should be performed. In all other cases, tumor enucleation is the gold standard of treatment. The issue of minimally invasive surgical access is relevant. Thoracoscopic access has limitations for tumors located in the lower thoracic esophagus closer to the esophageal-gastric junction. In this regard, a laparoscopic approach with the possibility of transhiatal mobilization of the esophagus provides an adequate opportunity for tumor enucleation.Clinical case description. We hereby report our case study in which we employ the use of laparoscopic transhiatal enucleation to remove leiomyoma of the lower thoracic part of the esophagus. A 47-year-old female presented to P.A. Herzen Moscow Oncology Research Institute with complaints of pain in the epigastrium, discomfort behind the sternum when taking solid food. R0 resection was performed. During the one year follow-up period no sign of disease recurrence was observed.Conclusion. This approach, in our opinion, is fully justified, with careful selection of patients and compliance with guidelines of cancer surgery. Laparoscopic approach with transhiatal mobilization of the esophagus provides a good opportunity to perform the enucleation of mesenchymal tumors localized in the lower third of the thoracic region, at the level of the supraphrenic and abdominal segments.
Changes in blood monocyte functional prof le in breast cancer
Authors: Fedorov A. A. , Prostakishina E. A. , Patysheva M. R. , Frolova A. A. , Iamshchikov P. S. , Larionova I. V. , Stakheyeva M. N. , Dorofeeva M. S. , Bragina O. D. , Choynzonov E. L. , Kzhyshkowska J. G. , Cherdyntseva N. V. 
Published: January 2023

The purpose of the study was to identify functional features of circulation monocytes in patients with nonmetastatic breast cancer.Material and Methods. The study cohort consisted of 10 breast cancer patients treated at Tomsk Cancer Research Institute. 7 healthy female volunteers were enrolled as a control group. CD14+16-, CD14+16+ and CD14-16+ monocytes subsets were obtained from blood by sorting. Whole transcriptome profling was provided in monocytes from patients and healthy females. Macrophages were differentiated from the obtained monocytes under in vitro conditions. The ability of conditioned media obtained from macrophages to infuence apoptosis and proliferation of MDA-MB 231 cell line was evaluated.Results. Transcriptomic profling revealed signifcant changes in monocytes of breast cancer patients. CD14+16- subset showed higher expression of transporters ABCA1 and ABCG1; chemokines CCR1, CRRL2, CXCR4; maturation and differentiation factors Mafb and Jun; endocytosis mediating factors CD163 and Siglec1; proteases and tetrasponins ADAM9, CD151, CD82, and growth factor HBEGF in patient group. Macrophages derived from monocytes of breast cancer patients produced factors that supported proliferation of the MDA-MB 231 cell line, which was not observed for monocytes from healthy volunteers.Conclusion. Thus, breast carcinoma has a systemic effect on peripheral blood monocytes, programming them to differentiate into macrophages with tumor supporting capacity.
Análise dos indicadores de produção e distribuição do valor adicionado da Natura S.A
Authors: Silva Ana Paula Lemes da , Oliveira Renata Mendes de , Prado Thiago Alberto dos Reis , Oliveira Carlos Eduardo de 
Published: January 2023

Objetivo: O estudo teve por objeto analisar os indicadores de produção e distribuição do valor adicionado da Natura S.A, na busca por evidenciar o comportamento dos mesmos no período entre 2011 e 2020.
Metodologia: Este estudo caracteriza-se como uma pesquisa de natureza documental e descritiva. A coleta de dados foi realizada junto à base de dados da B3 e compreendeu o levantamento de informações da Demonstração do Valor Adicionado (DVA), além da consideração de indicadores de produção e distribuição do valor adicionado. Os dados foram analisados de forma analítica, com elaboração de tabelas para evidenciar as informações coletadas de forma estruturada.
Resultados: Os resultados demonstraram que o indicador de produção que mais se destaca é relacionado à riqueza própria (GPRP). Os valores adicionados apresentaram comportamento crescente durante o período observado, com destaque ao valor gerado pela empresa no ano de 2020. A distribuição dos valores gerado se dá principalmente entre Pessoal, Impostos, Taxas e Contribuições e Remuneração de Capitais de Terceiros, o que impacta nos indicadores de distribuição ao Pessoal (PDVAP), distribuição ao Governo (PDVAG) e distribuição ao Capital de Terceiros (PDVACT).
Contribuições do Estudo: Esta pesquisa contribuem para teoria e para a prática no campo da contabilidade. De forma geral, os resultados apresentados reforçam o exposto por outras pesquisas e oferece novas evidências em relação a ampliação do período de observação. Ademais, auxiliam na compreensão em relação ao processo de produção e distribuição do valor adicionado, bem como ao demonstrar a relevância da DVA.
Chiral Inversion of Pharmaceutical Drugs - Mini Review
Authors: Aboul-Enein Hassan Y. , Kannappan Valliappan , Kanthiah Selvakumar 
Published: January 2023

Abstract:2-Arylpropionic acid nonsteroidal anti-inflammatory drugs (NSAIDs) provide one of the most demonstrated pharmaceutical examples of chiral inversion. Chiral inversion depends on various factors (viz. biological-, solvent-, light-, temperature-induced, etc.) and the energy barrier associated with the stereogenic element present in the chiral molecule. The pharmacological properties of chiral drugs depend on the activity of one enantiomer or both the enantiomers targeting different biological targets. Consequently, chiral inversion can alter the biological activities of the pharmaceutical drug. Hence a better understanding of chiral inversion, factors facilitating such inversion, and the tools employed to determine chiral inversion are of great significance from a pharmacological and toxicological perspective.
Chromosome-level Genome Assembly and Sex-specific Differential Transcriptome
of the White-backed Planthopper, Sogatella furcifera
Authors: Zhang Chuan-Xi , Ye Yu-Xuan , Li Dan-Ting , Zhang Si-Yu , Shen Zhi-Cheng 
Published: January 2023

Background:
The white-backed planthopper (WBPH), Sogatella furcifera, causes great
damage to many crops (mainly rice) by direct feeding or transmitting plant viruses. The previous genome
assembly was generated by second-generation sequencing technologies, with a contig N50 of
only 51.5 kb, and contained a lot of heterozygous sequences.

Methods:
We utilized third-generation sequencing technologies and Hi-C data to generate a highquality
chromosome-level assembly. We also provide a large amount of transcriptome data for fulllength
transcriptome analysis and gender differential expression analysis.

Results:
The final assembly comprised 56.38 Mb, with a contig N50 of 2.20 Mb and a scaffold N50 of
45.25 Mb. Fourteen autosomes and one X chromosome were identified. More than 99.5% of the assembled
bases located on the 15 chromosomes. 95.9% of the complete BUSCO Hemiptera genes were
detected in the final assembly and 16,880 genes were annotated. 722 genes were relatively highly expressed
in males, while 60 in the females.

Conclusion:
The integrated genome, definite sex chromosomes, comprehensive transcriptome profiles,
high efficiency of RNA interference and short life cycle substantially made WBPH an efficient
research object for functional genomics.
Multilevel Pharmacological Effects of Antipsychotics in Potential Glioblastoma
Treatment
Authors: Awuah Wireko Andrew , Alexiou Athanasios , Kalmanovich Jacob , Mehta Aashna , Huang Helen , Abdul-Rahman Toufik , Cheng  Ng Jyi , Yarlagadda Rohan , Kamanousa Karl , Kundu Mrinmoy , Nansubuga Esther Patience , Hasan Mohammad Mehedi , Lyndin Mykola , Isik Arda , Sikora Vladyslav 
Published: January 2023

Abstract:
Glioblastoma Multiforme (GBM) is a debilitating type of brain cancer with a high mor-tality rate. Despite current treatment options such as surgery, radiotherapy, and the use of te-mozolomide and bevacizumab, it is considered incurable. Various methods, such as drug reposition-ing, have been used to increase the number of available treatments. Drug repositioning is the use of FDA-approved drugs to treat other diseases. This is possible because the drugs used for this purpose have polypharmacological effects. This means that these medications can bind to multiple targets, resulting in multiple mechanisms of action. Antipsychotics are one type of drug used to treat GBM. Antipsychotics are a broad class of drugs that can be further subdivided into typical and atypical classes. Typical antipsychotics include chlorpromazine, trifluoperazine, and pimozide. This class of antipsychotics was developed early on and primarily works on dopamine D2 receptors, though it can also work on others. Olanzapine and Quetiapine are examples of atypical antipsychotics, a cate-gory that was created later. These medications have a high affinity for serotonin receptors such as 5-HT2, but they can also act on dopamine and H1 receptors. Antipsychotic medications, in the case of GBM, also have other effects that can affect multiple pathways due to their polypharmacological effects. These include NF-B suppression, cyclin deregulation, and -catenin phosphorylation, among others. This review will delve deeper into the polypharmacological, the multiple effects of antipsy-chotics in the treatment of GBM, and an outlook for the field's future progression.
Traditional use, Phytochemistry and Pharmacological Properties of the Genus Onopordum
Authors: Mouffouk Chaima , Mouffouk Soumia , Mouffouk Sara , Haba Hamada 
Published: January 2023

Background:The genus Onopordum (Asteraceae), with about 40 species, is composed of perennials and spermatophyte plants, which are widely used in popular medicine for the treatment of several human diseases. Plants of this genus constitute an interesting source of bioactive molecules with a wide range of pharmacological applications.Objective:In this context, the current study describes a critical review of traditional uses, phytochemistry, and pharmacological effects of the genus Onopordum in order to establish a valuable database for future ethnopharmacological surveys on this genus.Methods:For this, all bibliographic data covering the period of 1970 to 2022 were collected and analyzed.Results:Only 19 species from the genus Onopordum were studied. They are traditionally used to treat gastric, renal, respiratory, urinary, and gynecological diseases and in the food industry for cheese production. Indeed, it was found that Onopordum species are rich in flavonoids, phenolic compounds, terpenoids, alkaloids, tannins, and steroids. These plants exhibit several interesting biological activities including: antioxidant, antimicrobial, antiproliferative, apoptotic, cytotoxic, antitumor, anticholinergic, larvicidal, analgesic and antipyretic, hypotensive, antiepileptic, and anticonvulsant activities. Furthermore, their hemostatic, anti-inflammatory, and moisturizing properties, increase their usefulness in the cosmetic field.Conclusion:According to the present study, Onoporadum species constitute an important natural source of secondary metabolites with potential therapeutic, cosmetic, and nutritional applications. However, the focus has been only on 19 species and the publications were not very explanatory, Therefore, in-depth pharmacological and phytochemical studies are needed to fully exploit the therapeutic potential and the chemical composition of Onopordum species.