bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forged Facial Video Detection Framework Based on Multi-region Temporal Relationship Feature
Authors: Fang Xing , Hao Yanni , Luo yin , Cao Jia 
Published: May 2023

Abstract
Face generation and manipulation techniques based on deep learning has enabled the creation of sophisticated forged facial video, which is indistinguishable by human eyes. However, illegal use of deep fake technology will have a serious impact on social stability, personal reputation and even national security. Therefore, detection technology of fake facial video is of great significance to protect national security and maintain social order. Although the existing video-based fake face video detection technology has achieved good detection performance on the public fake face video database, there are still the following problems: (1) the existing technology uses 2D attention mechanism to obtain local region features from face images, and lacks a 3D attention mechanism to obtain local area features from face videos; (2) After obtaining local area features, the existing technology is directly used to classify or only model the inter-regional relationship of images, without modeling the temporal relationship between regions of the video. This paper proposes a fake facial video detection framework based on multi-region temporal relationship features, including designing a three-dimensional attention mechanism to extract local features of multiple regions of the face from the video. In order to model the time series relationship between different facial areas, a time series graph convolution neural network is also introduced to extract the time series relationship features between multiple areas. In order to model the time sequence relationship between different face regions, the convolution neural network of time the sequence diagram is also introduced to extract the characteristics of the time sequence relationship between multiple regions. Through the change characteristics of time sequence relationship between facial regions, the timing inconsistency of face video is detected, so as to determine whether the face has been deeply forged. Through experiments on multiple data sets, the experimental results of the model accuracy test show that the method proposed in the present invention achieves the highest detection accuracy, and the accuracy in the FF++ (LQ) data set is 18.19% higher than the benchmark method. The experimental results of the generalization ability test show that the method proposed in the present invention achieves the highest generalization performance, and the detection accuracy of the Celeb-DF data set is 11.92% higher than that of the benchmark method.
Feasibility of collecting longitudinal patient-reported outcomes in individuals with relapsed or refractory large B-cell lymphoma who received chimeric antigen receptor T-cell (CART) therapy
Authors: Balitsky Amaris , Pond Greg , Davies Gwynivere , Fraser Graeme , Kouroukis Tom , Levine Mark , Meyer Ralph , Foley Ronan 
Published: May 2023

Abstract
Purpose
Chimeric antigen receptor T-cell (CART) therapy has shown clinical efficacy in refractory and relapsed large B-cell lymphomas, but is associated with serious acute and long-term toxicities. To understand the patient perspective, we measured a patient-reported outcome (PRO), specifically, health-related quality of life (HRQoL), at multiple time points over one year.
Methods
This was a prospective feasibility study of a cohort of patients who were eligible for standard of care CART therapy, tisagenlecleucel. Demographic data and disease characteristics were collected. HRQoL was measured using FACT-Lym at baseline, and months 1, 3, 6 and 12. FACT-Lym includes FACT-G (physical, social, emotional and functional well-being domains), plus a lymphoma subscale.
Results
Thirty-four of 35 patients approached, consented to participate. Two of them did not receive their infusion due to progressive disease. Fifty percent were female and median age was 62 (23–77). Twenty-nine patients (91%) completed baseline FACT-Lym and 20 of 21 (95%) eligible patients completed 12-month FACT-Lym. 52% completed all 4 post-baseline FACT-Lym measures. Exploratory analyses for changes in FACT-Lym scores are reported.
Conclusion
It is feasible to measure longitudinal PROs in patients who receive CART therapy. This study will inform future studies in evaluating innovative ways to administer CART therapy.
Studying peacebuilding and nonviolence: the ethos and experience of the International Centre of Nonviolence, South Africa
Authors: Harris Geoffrey , Hemson Crispin , Kaye Sylvia , Plug Simone 
Published: May 2023

Abstract
The International Centre for Nonviolence at Durban University of Technology is a major player in the study of peacebuilding and nonviolence in Africa. ICON’s overall aim is to help African communities achieve sustained peace, which means that its teaching, research and community engagement are transformational in their methods and outcomes, with an immediate impact on the lives of those involved. In practice, this means the use of transformative learning processes in our undergraduate teaching and participatory action research in the research theses which we supervise at master’s and doctoral level. This chapter explains the theory, experience and challenges of transformative learning and participatory action research. It then reflects on the effects which these approaches have had on our students and the contributions which they have made to the building of sustained peace across the continent.
periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1: case report and bibliometric analysis
Authors: Zhang Xiaoyu , Yu Jianfa , Li Yang , Li Ping 
Published: May 2023

Abstract
Background: Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neuroendocrine tumors, and the most frequent target organs of periampullary neuroendocrine neoplasms (NENs) in NF1 patients are the duodenum and peri-ampullary region.
Case presentation: A 50-year-old male patient was admitted to our hospital after experiencing progressive skin and scleral yellowing for over six months. An abdominal contrast-enhanced computed tomography (CT) scan showed a tumor in the periampullary region, which measures 1.2×1.4cm in size and showed a progressive enhancement. Magnetic resonance cholangiopancreatography (MRCP) showed the dilation of intra- and extrahepatic bile ducts. The patient was diagnosed with an ampullary tumor with the possibility of malignancy. A Whipple procedure was performed. Microscopically, the duodenum tumor invades the mucosa, sphincter, and muscular layer of the duodenal papilla. Histologic hematoxylin and eosin (HE)stain confirmed the presence of duodenal G1 neuroendocrine tumor (NET). In order to get the whole picture of NENs, a bibliometric analysis was performed, which showed that publications about periampullary NENs increase gradually every year, and most of them focus on the treatment and diagnosis of NENs.
Conclusions: We reported a case of periampullary duodenal NET in a patient with NF1, and carried out a bibliometric analysis on periampullary NENs.
CD31 defines a subpopulation of human adipose-derived regenerative cells with potent angiogenic effects
Authors: Dhumale Pratibha , Nielsen Jakob Vennike , Hansen Anne Cathrine Schmidt , Burton Mark , Beck Hans Christian , Jørgensen Mads Gustaf , Toyserkani Navid Mohamadpour , Haahr Martha Kirstine , Hansen Sabrina Toft , Lund Lars , Thomassen Mads , Sørensen Jens Ahm , Andersen Ditte Caroline , Jensen Charlotte Harken , Sheikh Søren P 
Published: May 2023

Abstract
Cellular heterogeneity represents a major challenge for regenerative treatment using freshly isolated Adipose Derived Regenerative Cells (ADRCs). Emerging data suggest superior efficacy of ADRCs as compared to the ex vivo expanded and more homogeneous ADRCs (=ASCs) for indications involving (micro)vascular deficiency, however, it remains unknown which ADRC cell subtypes account for the improvement.
Surprisingly, we found regarding erectile dysfunction (ED) that the number of injected CD31+ ADRCs correlated positively with erectile function 12 months after one bolus of autologous ADRCs. Comprehensive in vitro and ex vivo analyses confirmed superior pro-angiogenic and paracrine effects of human CD31+ enriched ADRCs compared to the corresponding CD31- and parent ADRCs. When CD31+, CD31- and ADRCs were co-cultured in aortic ring- and corpus cavernous tube formation assays, the CD31+ ADRCs induced significantly higher tube development. This effect was corroborated using conditioned medium (CM), while quantitative mass spectrometric analysis suggested that this is likely explained by secretory pro-angiogenic proteins including DKK3, ANGPT2, ANAX2 and VIM, all enriched in CD31+ADRC CM. Single-cell RNA sequencing showed that transcripts of the upregulated and secreted proteins were present in 9 endothelial ADRC subsets including endothelial progenitor cells in the heterogenous non-cultured ADRCs. Our data suggest that the vascular benefit of using ADRCs in regenerative medicine is dictated by CD31+ ADRCs.
Quantitative evaluation of smart bed comfort in different typical conditions during resting.
Authors: Bai Xiangtian , Zhong Ming , Liu Yonghong , Hu Yafan , Ma Jun 
Published: May 2023

Abstract
In response to the general inability of smart beds to meet the health needs of chronic disease management and long-term care, this study proposed to investigate smart bed comfort in different typical conditions. The objective body pressure distribution and subjective comfort of participants were collected when the smart bed was in typical conditions. Pressure sensor mat was used to accurately measure pressure distribution. Participants reported in real time on the subjective comfort for each typical condition. Statistical data analysis intended to investigate changes in overall and local comfort when the smart bed is in different typical conditions, the correlation between perceived comfort and body pressure distribution. During the experiment, mean and peak pressures increased by up to 87.19% and 92.85%, respectively, owing to changes in smart bed conditions. However, major body pressure indicators correlated with the overall and local comfort of each area were not completely aligned. Statistical data analysis shows the im-portance of evening out forces and reducing peak pressures. Apart from mean pressure, peak pressure, particularly at the buttock, thigh and shank areas, is the key factor in comfort evaluation. Moreover, adequate bed board partitioning and linkage mechanism between adjacent boards better fit the body curve and enhance comfort. Accordingly, ensuring relatively balanced body forces and avoiding the feeling of weightlessness improve user comfort and health significantly. The succeeding study will further investigate the relationship between smart bed comfort and changes in free lying positions and moving activities, hoping to provide a comfort studies basis for long-term care.
TEAD4 antagonizes cellular senescence by remodeling chromatin accessibility at enhancer regions
Authors: Zhang Donghui , Zhu Yanmei , Ju Yanmin , Zou Xiaopeng , Zhang Hongyong , Guan Yiting 
Published: May 2023

Abstract
Dramatic alterations in epigenetic landscapes are known to impact genome accessibility and transcription. Extensive evidence demonstrates that senescent cells undergo significant changes in chromatin structure; however, the mechanisms underlying the crosstalk between epigenetic parameters and gene expression profiles have not been fully elucidated. In the present study, we delineate the genome-wide redistribution of accessible chromatin regions that lead to broad transcriptome effects during senescence. We report that the distinct senescence-activated accessibility regions (SAAs) are always distributed in H3K27ac-occupied enhancer regions, where the SAAs are responsible for elevated flanking SASP expression and aberrant cellular signaling relevant to SASP secretion. Mechanistically, a single transcription factor, TEAD4, moves away from H3K27ac-labled SAAs to allow for prominent chromatin accessibility reconstruction during senescence. The enhanced SAA signal driven by TEAD4 suppression subsequently induces a robust increase in the expression of adjacent SASP genes and the secretion of downstream factors, which contribute to the progression of senescence. Our findings illustrate a dynamic landscape of chromatin accessibility following senescence entry, and further reveal an insightful function for TEAD4 in regulating the broad chromatin state that modulates the overall transcriptional program of SASP genes.
The Value of Rockall and Forrest Classification in the Prognosis of Patients With Gastrointestinal Bleeding Applying to the Emergency Department
Authors: TUNCAR Alpay , CANBAZ Hayri , KIRIŞ Tolga , ÇOLAK Tamer , ALAY Mustafa Tarık , ÇAKIR Adem 
Published: May 2023

Abstract
Purpose
Gastrointestinal system bleeding (GIB) is a common and highly morbid condition with high mortality rates frequently observed in emergency departments. Several scoring systems have been used to predict mortality and rebleeding in these cases. Among these scoring systems, Rockall Score (RS) and Forrest classification (FS) are commonly used. In our study, we aimed to evaluate the predictive power of RS for mortality, rebleeding, and the need for blood transfusion, and to provide benefits to clinicians.
Methods
The study was designed as a retrospective and single-center study, conducted between January 1, 2017, and January 1, 2018. Demographic data, RS and FS scores, clinical outcomes (mortality, rebleeding, blood transfusion requirement, and final outcomes) of the cases were evaluated.
Results
Of the 109 patients in our study, 60.6% were male, and the mean age was 67.83 ± 16.75 years. The most common presenting complaint was black stool, and the most frequently detected finding was melena. The most common endoscopic diagnosis was erosive gastritis (24.8%). The use of acetylsalicylic acid and anticoagulants was significantly higher in cases of lower gastrointestinal bleeding. There was a negative correlation between the RS score and hemoglobin level of the patients (r=-0.537; p < 0.001), while a positive linear correlation was observed between RS and mortality (r = 0.352; p < 0.001), rebleeding (r = 0.381; p < 0.001), and blood transfusion requirement (r = 0.489; p < 0.001). Additionally, there was a positive linear correlation between the amount of blood product given to the patient and RS (r = 0.432; p < 0.001). The discriminatory power of RS for predicting mortality, rebleeding, and blood transfusion was evaluated, and our results showed an AUC of 0.802 (95% CI = 0.684–0.921; p < 0.001) for mortality, an AUC of 0.764 (95% CI = 0.641–0.886; p < 0.001) for rebleeding, and an AUC of 0.815 (95% CI = 0.731–0.899; p < 0.001) for blood transfusion requirement.
Conclusions
RS provides risk stratification in cases of GIB and aids in early treatment and prognosis prediction for high-risk patients. Furthermore, it has a high predictive power in determining rebleeding, mortality, and the need for blood transfusion. We believe that RS can be beneficial for clinicians in the management, prognosis, and mortality risk assessment of GIB cases, particularly in clinics such as emergency departments where a large number of patients need to be evaluated and treatment and discharge decisions are made within a short period of time.
Enhancing Accessibility in Retinal Imaging through the Universal Smartphone Adapter
Authors: Latip Aisya Amelia Abdul , Kipli Kuryati , Kamaruddin Abang Mohammad Nizam Abang , Sapawi Rohana , Lias Kasumawati , Jalil Muhammad Arif , Tamrin Khairul Fikri , Tajudin Nurul Mirza Afiqah , Ong Han Yi , Mahmood Muhammad Hamdi , Jali Suriati Khartini , Sahari Siti Kudnie , Mat Dayang Azra Awang , Lim Lik Thai 
Published: May 2023

Abstract
Background
The revolutionary technology of smartphone-based retinal imaging has been consistently improving over the years. Smartphone-based retinal image acquisition devices are designed to be portable, and easy to use, besides being low-cost which enables eye care to be more widely accessible especially in geographically remote areas. This enables early disease detection for those who are in low- and middle- income population or just in general has very limited access to eye care. This study investigates the limitation of smartphone compatibility of existing smartphone-based retinal image acquisition devices. Additionally, this study aims to propose a universal adapter that is usable with an existing smartphone-based retinal image acquisition device, the PanOptic ophthalmoscope. This study also aims to simulate the reliability, validity, and performance overall of improved develop prototype. Existing studies have shown that the concept of smartphone-based retinal imaging is still limited to screening purposes only. Furthermore, existing smartphone-based devices also have a limited smartphone compatibility where it is only usable with specific smartphone models.
Methods
A literature review was conducted that identifies the limitation of smartphone compatibility among existing smartphone-based retinal image acquisition devices. Designing and modelling of proposed adapter was performed using the software AutoCAD 3D. For proposed performance evaluation, finite element analysis (FEA) in the software Autodesk Inventor and 5-point scale method were applied.
Results
It was identified how a universal adapter is beneficial in broadening the usability of existing smartphone-based retinal image acquisition devices as most of the devices that are available in the market have limited smartphone compatibility. A functional universal adapter was developed and found to be suitable with two smartphones that have different camera placement and dimensions. The proposed performance evaluation method was able to generate efficient stress analysis of the proposed adapter design.
Conclusion
The concept of a universal and suitable adapter for retinal imaging using the PanOptic ophthalmoscope was presented in this paper. Performance evaluation methods proposed were identified to be sufficient to analyze the behavior of proposed adapter when an external load is applied and determine its suitability with the PanOptic ophthalmoscope.
A double negative cascade mediated by epigenetic modifications of EFD (Exine Formation Defect) to HB21 coordinates anther development in plant
Authors: Zhang Cheng , Xiong Ao-Tong , Ren Meng-Yi , Zhao Yanyun , Huang Min-Jia , Zhang Zheng , Wang Yun , Zheng Quan-Quan , Yang Zhong-Nan 
Published: May 2023

Abstract

Epigenetic modifications are essential for plant development. EFD encodes a SAM-dependent methyltransferase essential for the pollen wall pattern formation and male fertility in Arabidopsis. Here, we found that the expression of DRM2, a de novo DNA methyltransferase in plants, can complement the defects of efd, suggesting its de novo DNA methyltransferase ability. Genetic analysis reveals that EFD plays roles through HB21 as its knockout fully restored the efd fertility. The methylation and H3K27me3 analysis indicates that EFD represses the transcription expression of HB21 through epigenetic modifications. Besides, both EMSA and tobacco transient expression assays showed that HB21 repressed the expression of the genes including CalS5, RPG1/SWEET8, CYP703A2 and NST2 which are essential for pollen formation and anther dehiscence. Altogether, our study reveals a double negative regulatory cascade mediated by epigenetic modifications to coordinate anther development, which provides new insights into epigenetic regulation and anther development.
Acceptability of STEPPS for outpatient adolescents in the United States: A case study
Authors: Cano Kiana , Balzen Kennedy M. , Vanwoerden Salome , Penner Francesca , Sharp Carla 
Published: May 2023

Abstract
Background. Borderline personality disorder (BPD) is a severe mental illness that typically onsets during adolescence. Emotion dysregulation is a key feature of BPD, and several interventions have been developed to target these difficulties. However, many barriers to care exist for adolescents with BPD, such as difficult-to-find and time-consuming treatment. Considering these limitations, the evidence-based group treatment Systems Training for Emotional Predictability and Problem Solving (STEPPS) was previously adapted for adolescents with BPD or symptoms of BPD and has shown promise in a preliminary study, but more work is needed examining STEPPS for use in adolescents.
Methods. This paper uses a case study approach to evaluate STEPPS in two adolescents and their parents who completed 18 weeks of STEPPS intervention. Adolescents and their parents completed the STEPPS assessment of borderline personality features weekly during treatment to track changes over time. Moreover, participants completed assessments of emotion regulation, interpersonal difficulties, and general psychopathology before treatment, after program completion, and at 6- and 12-month follow-ups.
Results. Results showed that both adolescents reported a decline in BPD features following STEPPS, albeit with unique patterns in decline. Parent reports of youth BPD features were less straightforward but suggested improvement in BPD features during treatment, but stability or small increases in symptoms at post-treatment and follow-up assessments. Results also illustrated improvements in emotion regulation, reduced stress in the parent-adolescent relationship, improvement in inadequate parent-adolescent boundaries, and a decline in functional impairment.
Conclusions. Overall, STEPPS may offer a brief and cost-effective treatment for BPD, although more research is needed to fully establish its efficacy in adolescents.
A Comparison of Film Analysis Software for Radiotherapy Patient-Specific Quality Assurance
Authors: Buddhavarapu Athreya 
Published: May 2023

Abstract
Aim:
The aim of this study was to investigate the suitability of three Radiochromic film analysis software programs for radiotherapy patient-specific quality assurance (PSQA): FilmQA Pro v5.0, SNC Patient v6.2, and eFilmQA v5.0.
Methods:
Film calibration was conducted for each software followed by three sets of measurements. The first set assessed calibration accuracy by comparing measured and delivered doses at increments different from those used for calibration. The second set used each software to conduct PSQA through gamma analysis on 10 Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiation Therapy (SBRT) patients. The third set utilized SNC Patient and eFilmQA to carry out gamma analysis on a collection of 4 digital test images, eliminating delivery and scanning uncertainties from impacting the analysis. Key supporting features within each software for conducting gamma analysis were identified.
Results:
In general, FilmQA Pro and eFilmQA were deemed comparable and favoured over SNC Patient due to the presence of key features such as triple channel dosimetry, auto-optimization, and dose scaling. FilmQA Pro has a substantial user base and established reputation. eFilmQA, having been introduced more recently, serves as a viable alternative to FilmQA Pro, having been further refined for stereotactic radiotherapy PSQA.
Conclusion:
This study investigated the suitability of three film analysis software programs (FilmQA Pro, eFilmQA and SNC Patient) for radiotherapy PSQA. Results from the investigation indicated that both FilmQA Pro and eFilmQA were comparable in performance and preferred over SNC Patient.