bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of an alternative reconstructed individual patient data-based approach for budget impact analysis of anticancer drugs
Authors: Ma Yue , Zhou Jiting , Ye Yuxin , Ma Aixia , Li Hongchao 
Published: June 2023

Abstract
Background
The duration of treatment (DOT) of the initial intervention and subsequent treatment is the key to determining the accuracy of anticancer-drug budget impact analysis (BIA) calculations. However, existing studies only use simple assumptions as a proxy for DOT, resulting in a high degree of bias.

Objectives
To enhance the accuracy and reliability of anticancer-drug BIA and solve the problem regarding DOT, we propose an alternative individual patient data (IPD)-based approach that reconstructs IPD from the published Kaplan Meier survival curves to estimate DOT.

Methods
We developed a four-step methodological framework for this new approach, taking the use of pembrolizumab in treating microsatellite-instability–high (MSI-H) advanced colorectal cancer as an example: (1) reconstructing the IPD; (2) calculating the total DOT of the initial intervention and subsequent treatment for each patient; (3) assigning a randomized time and DOT; and (4) multiple replacement sampling and calculation of the mean value.

Results
Using this approach, the average DOT for the initial intervention and subsequent treatment in each year of the BIA time horizon can be calculated and used to calculate the resources consumed and costs in each year. In our example, the average DOT for the initial intervention with pembrolizumab from the first to the fourth year was 4.90, 6.60, 5.24, and 5.06 months, respectively, while the average DOT for subsequent treatment was 0.75, 2.84, 2.99, and 2.50 months, respectively.

Conclusions
The reconstructed IPD-based approach can improve the accuracy and reliability of anticancer-drug BIA compared with conventional methods, and can be widely used, especially for anticancer drugs with excellent efficacy.
Perception of health risks in contexts of extreme climate change in semiarid Northeastern Brazil: an analysis of the role of socioeconomic variables
Authors: de Moura Brito Júnior Valdir , de Magalhães Henrique Fernandes , Albuquerque Ulysses Paulino 
Published: June 2023

Abstract
Background
Global climate change poses a significant challenge in contemporary society, particularly affecting vulnerable populations like small farmers residing in arid and semiarid regions. This study aims to investigate the perception of health risks and adaptive responses in the semiarid region of Northeast Brazil (NEB). Four questions were formulated: (1) How do socioeconomic factors influence the perception of health risks during extreme climate events? (2) How do socioeconomic factors impact the adoption of adaptive responses to mitigate health risks during extreme weather events? (3) How does the perceived risk level affect the utilization of adaptive responses? (4) What is the influence of extreme climate events on the perceived risks and the adoption of adaptive responses?

Method
The research was conducted in the rural community of Carão, situated in the Agreste region of the State of Pernambuco, NEB. Semi-structured interviews were conducted with 49 volunteers aged 18 and above. The interviews aimed to gather socioeconomic information, including sex, age, income, access to healthcare services, family size, and education level. Additionally, the interviews explored the perceived risks and responses employed during different extreme climate events such as droughts or heavy rainfall. The perceived risks and adaptive responses data were quantified to address the research questions. Generalized linear models were employed to analyze the data for the first three questions, while the nonparametric Mann–Whitney test was used for the fourth question.

Results
The study found no significant differences in the level of perceived risk and adaptive responses between the two climate extremes. However, the quantity of adaptive responses was found to be directly influenced by the perceived risks, regardless of the type of extreme climate event.

Conclusion
The study concludes that risk perception is influenced by various complex factors, including socioeconomic variables, and plays a critical role in the adoption of adaptive responses during extreme climate events. The findings suggest that specific socioeconomic variables have a more pronounced influence on how individuals perceive and adapt to risks. Furthermore, the results indicate a cause-and-effect relationship between perceived risks and the generation of adaptive responses. These findings contribute to a better understanding of the factors shaping risk perception and provide valuable insights for future studies in regions prone to extreme climate events.
Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study
Authors: Ko Ryoung-Eun , Kang Danbee , Cho Juhee , Na Soo Jin , Chung Chi Ryang , Lim Sung Yoon , Lee Yeon Joo , Park Sunghoon , Oh Dong Kyu , Lee Su Yeon , Park Mi Hyeon , Lee Haein , Lim Chae-Man , Suh Gee Young ,   the Korean Sepsis Alliance (KSA) investigators, Jeon Kyeongman , Lee Yeon Joo , Hong Sang-Bum , Cho Young-Jae , Heo Jeongwon , Lee Jae-myeong , Kim Kyung Chan , Chang Youjin , Lee Sang-Min , Hong Suk-Kyung , Cho Woo Hyun , Kwak Sang Hyun , Lee Heung Bum , Ahn Jong-Joon , Seong Gil Myeong , Lee Song-I. , Park Tai Sun , Lee Su Hwan , Choi Eun Young , Moon Jae Young 
Published: June 2023

AbstractBackgroundNumerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due to sepsis according to age group.MethodsThis study used data from the Korean Sepsis Alliance, an ongoing nationwide prospective multicenter cohort from 19 participating hospitals in South Korea. All adult patients diagnosed with sepsis in the emergency departments of the participating hospitals between September 2019 and December 2021 were included in the analysis. Clinical characteristics and outcomes were compared between male and female. Eligible patients were stratified by age into 19–50 years, 50–80 years, and ≥ 80 years old individuals.ResultsDuring the study period, 6442 patients were included in the analysis, and 3650 (56.7%) were male. The adjusted odds ratio (OR) [95% confidence interval (CI)] for in-hospital mortality for male compared with female was 1.15 (95% CI = 1.02–1.29). Interestingly, in the age 19–50 group, the risk of in-hospital mortality for males was significantly lower than that of females [0.57 (95% CI = 0.35–0.93)]. For female, the risk of death remained relatively stable until around age 80 (Pfor linearity = 0.77), while in males, there was a linear increase in the risk of in-hospital death until around age 80 (Pfor linearity < 0.01). Respiratory infection (53.8% vs. 37.4%,p < 0.01) was more common in male, whereas urinary tract infection (14.7% vs. 29.8%,p < 0.01) was more common in female. For respiratory infection, male had significantly lower in-hospital mortality than female in the age 19–50 groups (adjusted OR = 0.29, 95% CI = 0.12–0.69).ConclusionsGender may influence age-associated sepsis outcomes. Further studies are needed to replicate our findings and fully understand the interaction of gender and age on the outcomes of patients with sepsis.
Discovery of crime event sequences with constricted spatio-temporal sequential patterns
Authors: Maciąg Piotr S. , Bembenik Robert , Dubrawski Artur 
Published: June 2023

AbstractIn this article, we introduce a novel type of spatio-temporal sequential patterns called Constricted Spatio-Temporal Sequential (CSTS) patterns and thoroughly analyze their properties. We demonstrate that the set of CSTS patterns is a concise representation of all spatio-temporal sequential patterns that can be discovered in a given dataset. To measure significance of the discovered CSTS patterns we adapt the participation index measure. We also provideCSTS-Miner: an algorithm that discovers all participation index strong CSTS patterns in event data. We experimentally evaluate the proposed algorithms using two crime-related datasets: Pittsburgh Police Incident Blotter Dataset and Boston Crime Incident Reports Dataset. In the experiments, the CSTS-Miner algorithm is compared with the other four state-of-the-art algorithms: STS-Miner, CSTPM, STBFM and CST-SPMiner. As the results of the experiments suggest, the proposed algorithm discovers much fewer patterns than the other selected algorithms. Finally, we provide the examples of interesting crime-related patterns discovered by the proposed CSTS-Miner algorithm.
Difficult removal of implantable venous access system: stepladder approach with wire stenting of a catheter—single-center experience
Authors: Awan Muhammed Younas , Almatar Zahra , AlShawa Mohammad Anas , Alshanafey Saud 
Published: June 2023

Abstract

Background
Port-a-catheter insertion and removal are common procedures performed for children with chronic disease or cancer. Although its removal is usually straightforward, some difficulties during the procedure can be encountered. Several methods have been described in the literature to handle those cases where lines have become stuck.

Aim
To describe our simple technique in dealing with stuck port-a-catheters during removal. We will additionally report the incidence and factors associated with this complication.

Methods
A retrospective chart review study was performed between January 2009 and December 2019. Of a collective 2040 ports that were removed during the research interval, cases of difficult port removal were collected and reviewed. In 42 cases, catheter removal difficulty is encountered, and a second incision at the venous access site is performed. Failure of this procedure in removing the stuck catheter is then followed by catheter stenting and removal over a guide wire.

Results
Difficult removal of port-a-catheters was experienced in 42 cases (2%). The mean age at removal for those cases was 6.6 years. Most of the port-a-cath removals were done after treatment completion (74%). Ports had been left in situ for a mean duration of 44 months. The stepladder technique with wire stenting of the catheter was successful in 37 cases (88%), while the rest were only partially removed (distal part). The retained part was extracted using an angiographic technique. No short- or long-term complications were encountered in any of those 42 patients.

Conclusions
Stepladder with wire stenting of catheters approach deals with difficult line removals. Our technique is, therefore, simple, feasible, and effective.

Level of evidence
IV.
Total arch replacement for the enhanced-fibrinolytic-type disseminated intravascular coagulation patient with endoleak after thoracic endovascular aortic repair for aortic dissection
Authors: Kanamoto Ryo , Oda Takeshi , Akaiwa Keiichi , Nakamura Katsuhiko , Tayama Eiki 
Published: June 2023

Abstract
Background
Endoleaks after stent graft treatment can cause disseminated intravascular coagulation (DIC), leading to a bleeding tendency.

Case presentation
A 69-year-old man received thoracic endovascular aortic repair (TEVAR) for acute type B aortic dissection. After that, he developed bleeding tendency, and the diameter of his distal aortic arch increased. We diagnosed him with enhanced fibrinolytic-type DIC associated with a type Ia endoleak. We decided to perform a total arch replacement for the endoleak closure. To reduce the risk of massive bleeding, transfusion of fresh frozen plasma and platelets, oral tranexamic acid, and intravenous recombinant human soluble thrombomodulin were administered in the perioperative period. According to the multidisciplinary approach, the DIC improved, and the patient recovered.

Conclusion
We successfully treated an endoleak-related DIC patient with bleeding tendency and combined correction for coagulopathy with supportive treatments.
A Novel Approach to Diagnostic Left and Right Heart Catheterization in a Patient With a Mechanical Prosthetic Tricuspid Valve
Authors: Kim Seulgi E. , Parekh Dhaval , Lam Wilson 
Published: June 2023

Abstract
A 47-year-old patient was experiencing dyspnea and fatigue concerning for right ventricular hypertension and new heart failure. Because of the risks associated with catheter entrapment, prosthetic valve leaflet damage, and valve thrombosis associated with crossing a mechanical valve, a novel technique was used for diagnostic left and right heart catheterization in a patient with mechanical tricuspid valve replacement and tortuous pulmonary arteries. Using a percutaneous subxiphoid approach to avoid traversing the mechanical valve without discontinuing anticoagulation, a Volcano fractional flow reserve pressure wire (Philips Volcano) was advanced for distal measurements of pressures and saturations.
Non-Criteria Antiphospholipid in Seronegative Antiphospholipid Syndrome: A Systematic Review
Authors: Shahideh Kianoosh , Rezaieyazdi Zahra , Khodashahi Mandana 
Published: June 2023

Background: Given the catastrophic results of antiphospholipid syndrome (APS) left untreated, the possible role of non-criteria antiphospholipid (aPL) in the diagnosis of seronegative (SN)-APS patients, and its impact on the timely treatment of people with SN-APS, the present review aimed to gather the available literature up to 2022 focusing on the role of non-criteria aPL in the diagnosis of SN cases suspected of APS using non-criteria aPL.
Methods: All published papers focusing mainly on the diagnosis of the SN-APS patients by non-criteria aPL were searched in four databases of PubMed, Scopus, Medline, and Web of Sciences, followed by manual search up to 20 February 2022 using such keywords as “Antiphospholipid Syndrome”, “Seronegative”, and “Non-Criteria”. Finally, 15 studies were selected after the detailed evaluation of the full-text versions.
Results: Based on the obtained results of our study, 24% to 81.9% of the SN-APS cases were positive for at least one isotype of non-criteria aPL. Thrombophilia events were more frequent in the APS population, compared to SN-APS; however, obstetric manifestations were more frequent in the SN-APS population, compared to seropositive-APS. Antivimentin/cardiolipin and antiphosphatidylserine/prothrombin IgG/IgM were introduced as the best non-criteria aPL to detect seronegative cases that were correlated with clinical manifestations.
Conclusion: It seems that a combination of testing for non-criteria aPL should be performed for cases suspected of APS with negative criteria markers.
Association of Mediterranean and DASH Diets Adherence with Dyslipidemia: A Cross-Sectional Study
Authors: Mehrabani Sanaz , Gerami Shirin , Nouri Mehran , Rajabzadeh-Dehkordi Milad , Askarpour Moein , Najafi Maryam , Omidbeigi Niloofar , Faghih Shiva 
Published: June 2023

Background: Some dietary patterns like Dietary Approaches to Stopping Hypertension (DASH) and/or Mediterranean Diet (MED) are often recommended to prevent Cardio Vascular Diseases (CVDs) based on their effects on lipid profile. Thus, we aimed to investigate the relationship between the DASH diet score and Mediterranean diet score with lipid profile in healthy individuals aged 20-50 years in Shiraz, Iran.
Methods: In this cross-sectional study, 236 participants were selected from Shiraz (Iran) medical centers through random cluster sampling. Information about food intake was collected using a 168-item Food Frequency Questionnaire (FFQ), then DASH score and MED diet score were calculated. Logistic regression was used to evaluate the relation between DASH and MED score adherence and lipid profile.
Results: Individuals in the highest tertile of MED and DASH pattern adherence had significantly lower Low-Density Lipoprotein (LDL) compared with those in the first tertile (p<0.05). In both crude and adjusted model, higher adherence to the MED pattern was associated with reduced odds of Total Cholesterol (TC) (OR: 0.30; 95% CI: 0.13–0.66 and OR: 0.27; 95% CI: 0.12–0.61) and LDL (OR: 0.36; 95% CI: 0.17–0.77 and OR: 0.32; 95% CI: 0.15–0.70). Moreover, higher adherence to the DASH pattern was associated with reduced OR of LDL in crude (OR: 0.43; 95% CI: 0.19–0.94) and TC in adjusted model (OR: 0.44; 95% CI: 0.20–0.96).
Conclusion: The study illustrated a negative association between the MED diet and serum levels of TC and LDL. Also, a higher DASH score was associated with lower TC. Future studies are necessary to confirm these findings.
Association of Personality Traits with Treatment Adherence in Vitiligo
Authors: Hedayati Arvin , Mani Arash , Hamidizadeh Nasrin , Chohedri Elnaz , Khalaj Hossein Moradi , Moshfeghinia Reza , Oji Bahare 
Published: June 2023

Background: Vitiligo is an acquired, auto-immune chronic skin disorder with different treatment modalities. Insufficient adherence to treatment is closely related to the efficacy of a prescribed treatment, and also, there are some associations between adherence behaviour and personality. Therefore, the study aimed to assess a relationship between five-factor personality traits and treatment adherence in patients with vitiligo.
Methods: In this cross-sectional study, patients with vitiligo who received Ultraviolet B (UVB) phototherapy were recruited. The Morisky Medication Adherence Scale (MMAS-8) assessed treatment adherence, and personality factors were evaluated by NEO Five-Factor Personality Inventory (NEO-FFI). Data were analysed using t-tests, correlations, and multiple regression.
Results: Among 70 participants, 62.9% had low adherence, 24.3% had medium adherence, and 12.9 % had high adherence. There was a positive correlation between neuroticism (p<0.001) and adherence score. Furthermore, a negative correlation between Agreeableness (p=0.13), Conscientiousness (p<0.001), Openness to experiences (p=005), Extraversion (p<0.001), and adherence score was obtained. In the regression analysis method, only the factors of neuroticism (p<0.001) and openness ( p=0.001), and conscientiousness ( p=0.016) predicted the dependent variable (adherence score) at the significance level.
Conclusion: This study demonstrated that openness to experience and conscientiousness positively affected adherence, while Neuroticism negatively affected adherence. Considering these personality factors can effectively screen poor adherence and improve treatment adherence.
Investigation of Static Balance Differences between Adolescents with Idiopathic Scoliosis and Healthy Age-matched Adolescents: A Cross-sectional Study
Authors: Larni Yasin , Mohsenifar Holakoo , Ghandhari Hasan , Salehi Reza 
Published: June 2023

Background: The aim of this study was to compare postural control between Adolescents with Idiopathic Scoliosis (AIS) and healthy adolescents.
Methods: In this cross-sectional study, 20 AIS adolescents with a right thoracic curvature between 10 and 45 degrees and 20 healthy adolescents were matched to compare postural control. Postural control assessments included Center of Pressure (COP) range and COP velocity in the Anteroposterior (AP) and Mediolateral (ML) directions, and the COP sway area in the standing position with opened eyes and closed eyes by the force plate.
Results: This study showed that the postural control variables in AIS adolescents and healthy adolescents in terms of COP range, COP velocity, and COP sway area in standing positions with open and closed eyes were significantly different with those of AIS adolescents being worse than those of healthy adolescents (all p<0.001). The interaction between Group and Condition (eyes open and eyes closed) was not significant for all variables (all p>0.05).
Conclusion: Differences in the postural control measures indicate postural instability in adolescents with AIS compared to healthy adolescents.
Organizaciones colectivas y turismo rural en Chiapas, México: ¿una oportunidad para el empoderamiento femenino?
Authors: García Arteaga Verónica  Fernanda , Cruz Coria Erika 
Published: June 2023

Diversos estudios aseveran que la integración de las mujeres en actividades económicas, les puede proveer de autonomía financiera y, en consecuencia, las encamina al proceso de empoderamiento femenino. Esto se presenta como una oportunidad para quienes, generalmente, se unen a organizaciones colectivas con el fin de mejorar su condición social y económica. A pesar de ello, se observa que la participación de las mujeres en la vida pública y privada continúa siendo notoriamente desigual. En este sentido, el objetivo es determinar los factores económicos y culturales que propician o inhiben el empoderamiento de las mujeres en organizaciones colectivas de turismo rural en el estado de Chiapas, México. La metodología que se implementó fue de corte cualitativo, mediante el estudio de casos múltiples y la aplicación de entrevistas semiestructuradas a mujeres originarias de los municipios de La Trinitaria y Amatenango del Valle en el estado de Chiapas, México. Los resultados permiten dar cuenta que la incorporación de las mujeres en el trabajo turístico es considerada como una oportunidad para acceder a un trabajo remunerado y tener control sobre sus recursos económicos; sin embargo, cotidianamente experimentan falta de autoconfianza, una marcada brecha en el tiempo promedio destinado a quehaceres domésticos y la permanente reproducción de relaciones patriarcales.