bluuebunny/crossref_metadata_2025_split huggingface dataset:
High D-Dimer Level at First Incident Cancer-Associated Venous Thromboembolism is a Predictor for Recurrence
Authors: S. Al-Eidan Fahad A. , Alotaibi Shaden A. , Almajid Hind M. , Alnahedh Taghreed A. , Abdel Gadir Abdel G. 
Published: February 2023

BACKGROUND:
Cancer is considered a major risk factor of venous thromboembolism (VTE). Whether the D-dimer level at first incident cancer-associated VTE can predict recurrence is not fully elucidated.

AIM:
The aim of this study was to assess the association between D-dimer level measured at first incident cancer-associated VTE and risk of recurrence.

METHODS:
In this study, the electronic records of all patients with first incident cancer-associated VTE were retrospectively retrieved and followed up for a period of 36 months. The measured levels of D-dimer and clinical predictors for each patient prior intervention were collected. Univariate and multivariant Cox regressions were fitted to estimate the hazard ratio (HR) and 95% confidence interval (CI).

RESULTS:
A total of 73 (34.3%) of 213 cancer-associated VTE patients had recurrent VTE. The crude recurrence rate was 11.4/100 person-years (95% CI, 9.2–14.2). The mean value of D-dimer was significantly higher seen in recurrent VTE patients than those without recurrence (14.8 ± 7.5 mg/L vs. 4.8 ± 5.7 mg/L, P < 0.001). The highest positive likelihood ratio using area under the receiver operating characteristic (ROC) curve occurred when a D-dimer threshold of 8.67 mg/L was chosen. At this threshold, the D-dimer was 92% sensitive and 80% specific in predicting recurrent VTE. The area under the ROC curve was 0.924 (95% CI 0.887–0.960, P < 0.001). Patients with a D-dimer ≥8.67 mg/L at first VTE in our study were 3.1-fold more likely to have a recurrence than those with lower D-dimer results.

CONCLUSION:
A D-dimer ≥8.67 mg/L measured at the first incident cancer-associated VTE was associated with a 3.1-fold increased hazard of recurrence events. Our finding suggests that a low D-dimer level at the time of first cancer-associated VTE is suitable in the clinical practice to avoid extended-duration anticoagulation.
Blastic Plasmacytoid Dendritic Cell Neoplasm
Authors: Quispe-Vicuna Carlos , Cabanillas-Lazo Miguel , Barja-Ore John , Mauricio-Vilchez Cesar , Guerrero Maria Eugenia , Munive-Degregori Arnaldo , Mayta-Tovalino Frank 
Published: February 2023

INTRODUCTION:
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological disease. There is an incidence. We aimed to evaluate the scientometrics characteristics of the scientific production on BPDCN between 2011 and 2020.

METHODOLOGY:
A cross-sectional and retrospective bibliometric study was performed. The search was executed in the Scopus database. Data were extracted based on a formula developed using thesaurus MeSH (Medline) and Emtree (Embase) terms. The retrieved papers received 11.2 citations per paper. Four of the ten most productive authors were from the United States. The institution with the highest impact (1064 citations) and the highest scientific output (46 papers) was the University of Texas MD Anderson Cancer Center (United States).

RESULTS:
The journal “Movement Disorders” rated first with 18 articles and 643 citations in terms of productivity and impact, and articles published in Q1 journals surpassed the remaining quartiles. The most cited articles had national collaboration. Conclusion the number of papers on BPDCN has been rising, yet journals with a higher quality tend to keep the similar publication rates, although they have shown a slight increase in the recent years.

CONCLUSIONS:
High-income countries' international collaboration is crucial for increasing publications impact; hence, greater collaborations between researchers and institutions from countries around the world are needed to expand knowledge on this subject.
Impact of COVID-19 Pandemic on Treatment Decisions of Patients Treated by Hematologists in Saudi Arabia
Authors: Bahashwan Salem M. , Alahwal Hatem M. , Almohammadi Abdullah T. , Radhwi Osman O. , Khan Shahida A. , Barefah Ahmed S. 
Published: February 2023

BACKGROUND:
As on March 12, 2020, the WHO declared COVID-19 as a global pandemic. Its rapid spread has posed major challenges to the management of health-care systems. Patients with hematological disorders, being immunocompromised in more ways than one, face a lot of challenges. Most of these patients require frequent visits to health-care facilities for transfusion support, infusions, surveillance, and follow-ups, which increase the risk of exposure and hence infection with severe acute respiratory syndrome coronavirus 2.

AIM:
We assessed the impact of the pandemic on the decisions of hematologists in Saudi Arabia.
Method: An online survey was done through questionnaires, to understand the decisions and course of clinical treatments taken. 45 hematologist answered 20-questions structured questionnaires through online link.

RESULTS:
The majority of hematologist have used virtual clinics in managing patients and have delayed or canceled well visits. Although some hematologist delayed treatment in stable patients like autologous stem cell transplantation for myeloma patients, the majority did not delay induction or consolidation therapies for patients with leukemia with curative intent plans.

CONCLUSION:
The crisis brought along with it challenges and opportunities to improve patient care through research and clinical practice. Telemedicine was sought for supporting outpatients. Malignancies were taken care of, with due precautions. Observations of decisions of hematologists resulted in the patients still being closely followed up and urgent treatments being attended to. The hematologists expressed satisfaction with the use of telemedicine. Online consultations and monitoring of patients could probably be taken as an alternative resource in such situations.
Role of ultraviolet ray filters and antioxidants in the prevention of DNA damage and oxidative stress associated with phototherapy in jaundiced term neonates
Authors: Saad Ahmed S. M. , Elsaeed Gamila S. M. 
Published: February 2023

Background
Phototherapy induces DNA damage by direct and indirect (oxidative) effects, which are prevented by ultraviolet (UV) filters and antioxidants.

Aim
Our goal was to assess DNA damage and oxidative stress associated with phototherapy and to prove the efficacy of UV filters and antioxidants for the prevention of DNA damage.

Patients and methods
The study included 160 jaundiced neonates who had been exposed to phototherapy for at least 48 h. The neonates were divided into four groups, 40 neonates in each group. The first (control) group received phototherapy only; the second group received antioxidants before and during phototherapy; the third group received phototherapy under an umbrella of UV filters; and the fourth group received phototherapy under both UV filters and antioxidants. DNA damage was assayed by the comet assay. Plasma total antioxidant capacity and total oxidant status levels were also measured and then oxidative stress index was calculated for all the four groups before and 48 h after phototherapy.

Results
The first group showed significant DNA damage accompanied with severe deterioration in all oxidative stress parameters by about 19%; the second group showed a decreasing trend as regards DNA damage and oxidative stress parameter deterioration to about 9%; the third group showed a more decreasing trend than group II to about 5%; but on the other hand, the fourth group showed complete DNA protection from damage with no changes in oxidative stress parameters.

Conclusion
Phototherapy causes DNA damage that can be completely prevented by combined concurrent use of UV filters and antioxidants.
Seroprevalence and risk factors of hepatitis C virus infection in a rural area in Gharbia Governorate (Quotour District)
Authors: Abdallah Afaf M. , Atalla Asmaa O. , El-Demerdash Attia Taher , El-Kafas El Sayed A.-R. 
Published: February 2023

Background
Egypt has the largest prevalence of hepatitis C virus (HCV) in the world with 11–14%. So, it is considered one of the most significant public health problems facing this country.

Aim
The aim was to estimate the prevalence of HCV infection in a rural area in Gharbia Governorate (Quotour District) and identify risk factors affecting the occurrence of hepatitis C infection in such an area.

Subjects and methods
This cross-sectional study was carried out in a rural area of Gharbia Governorate (Quotour District). A multistage random sample technique was used to recruit the calculated required sample (400), and a specially predesigned validated questionnaire sheet was the tool used for data collection in this study.

Results
The study revealed that the prevalence of HCV was 13%. The highest percentage of positive HCV infection was among participants aged more than 50 years old, females, unmarried, illiterate, unemployed, heavy smokers, diabetics, and HCV-positive family history. The risk factors of high positivity were in participants receiving clotting factors, and the most significant ones were reported in those visiting dental clinics. Sharing the same tools within the family was common in most participants, especially glucometer usage, which had a significant effect on positive cases.

Conclusion
The study revealed that HCV prevalence is 13% in Quotour District. Great attention should be paid to this district and other rural areas, and there should be an increase in awareness about HCV infection through health education programs and strict measures for infection control.
Study of serum level of insulin-like growth factor 1 in children with trisomy 21 in relation to age
Authors: Dawoud Heba , AbdEl-Azim Sahar , Mabrouk Maaly , El Sheikh Mai Rabei 
Published: February 2023

Background
Down syndrome (DS) is a chromosomal disease in which all or part of a third copy of chromosome 21 is present. From the age of 6–9 months postnatal, endogenous growth hormone induces the production of insulin-like growth factor 1 (IGF-1), which has a significant influence on development. As a result, when growth hormone takes over as the primary regulator of development, the growth retardation associated with DS becomes more apparent.

Aim
The study’s purpose was to compare IGF-1 levels in children with DS to those in healthy children.

Patients and methods
This prospective cross-sectional research was conducted on 20 children with DS as the study group who attended the outpatient clinic of the Tanta University Pediatric Department’s Genetics Unit. Twenty healthy normal children with matched age and sex served as the control group. All included children were given a full history, clinical examination, and blood IGF-1 test.

Results
Serum levels of IGF-1 were considerably lower in children with DS (122 ± 83.3 ng/ml) when compared with healthy controls (169.4 ± 33.3 ng/ml). The median IGF-1 levels were significantly lower in the DS patient group (2–6 years) than that in the age group 7–12 years (60.4 vs. 153, respectively). IGF-1 was significantly positively correlated with age and BMI.

Conclusion
IGF-1 level in children with DS was substantially lower than that in healthy children, especially in the age group 2–6 years. Moreover, IGF-1 positively correlated with age and BMI.
Accuracy of transcerebellar diameter in comparison with biparietal diameter, femur length, and fetal kidney length in the sonographic assessment of gestational age in the third trimester of pregnancy
Authors: Haggag Amr G.A. , Hamisa Manal F.M. , Elsayed-Atallah Walid M. , Marie Safaa K. 
Published: February 2023

Background
When gestational age (GA) cannot be calculated by the date of the last menstrual cycle or an early pregnancy ultrasound, the cerebellar diameter acts as an accurate predictor of GA in the fetus and a criterion against which other fetal parameters can be compared.

Aim
The aim of this work was to evaluate the accuracy of transcerebellar diameter (TCD) in comparison with biparietal diameter (BPD), femur length (FL), and fetal kidney length in the determination of GA in the third trimester of pregnancy.

Patients and methods
This was a cross-sectional analysis performed at Tanta University Hospital on 200 singleton uncomplicated pregnant women. Fetal biometric measurements were taken using ultrasound, including TCD, BPD, FL, and fetal kidney length.

Results
The percentages of accurate assessment of GA within 3 days were as follows: of 200 patients, the TCD gave accurate assessment within 3 days in 120 (60%) patients, the BPD gave accurate assessment within 3 days in 90 (45%) patients, the FL gave accurate assessment within 3 days in 100 (50%) patients, and both right and left kidney lengths gave accurate assessment within 3 days in 100 (50%) patients.

Conclusion
The TCD is a reliable single parameter for the determination of GA in the third trimester of pregnancy. TCD is a most valuable tool in cases where other established biometric indices are difficult to obtain.
Application of infection-control guidelines in hemodialysis units in El Mahalla El Kobra, Gharbia Governorate
Authors: Amer Reham M. , Ali Gamalat M. , Atalla Asmaa O. , Saied Shimaa M. 
Published: February 2023

Background
Application of infection-control precautions limits the occurrence of infections, which improves safety for hemodialysis patients.

Aim
To assess infection-control guidelines’ application and knowledge of healthcare providers regarding these guidelines in hemodialysis units.

Subjects and methods
A cross-sectional study was conducted at six hemodialysis units in EL Mahalla El Kobra, Gharbia Governorate, from September 2018 to December 2019. The study included all healthcare providers (physicians, nurses, technicians, and workers) in the studied units. Only 204 of them agreed to participate. A questionnaire sheet was developed and validated to collect background variables of the studied participants and their knowledge regarding infection-control guidelines. Also, observational checklists were used to evaluate the application of infection-control precautions by observing healthcare providers at initiation and termination of hemodialysis session.

Results
The majority of healthcare providers had good knowledge. The mean knowledge score was significantly higher among physicians and nurses who attended training courses. The application level of infection control was satisfactory regarding hemodialysis clinic, dialysis termination, and medication administration, whereas it was unsatisfactory regarding immunization and dialysis initiation. The deficient hospital resources were the main barrier for application.

Conclusions
The majority of the studied healthcare providers had good knowledge, but application of infection-control precautions was unsatisfactory regarding immunization of healthcare personnel and dialysis initiation. The main barrier to application was a lack of hospital resources. Training courses specific in infection control in hemodialysis units are recommended, with routine supervision of the staff’s practices.
Effect of ursodeoxycholic acid on indirect hyperbilirubinemia (nonhaemolytic and haemolytic) in neonates treated with phototherapy
Authors: Ali Dawood Sally M.S. , El-Sharkawy Hamed M. , Elsisi Alaa E.E. , Hamam Sarah A. 
Published: February 2023

Background
Hyperbilirubinemia is a global problem in neonates. Classic management for indirect neonatal hyperbilirubinemia includes phototherapy and exchange transfusion. Phototherapy shows disadvantages, and exchange transfusion is related to significant morbidity.

Aim
To assess the added role of ursodeoxycholic acid (UDCA) in reducing unconjugated hyperbilirubinemia in neonates undergoing phototherapy.

Patients and methods
Our randomized controlled trial was performed on neonates with hyperbilirubinemia who needed phototherapy and were admitted to the neonatal care unit at Tanta University Hospital from May 2017 to March 2019. A total of 120 neonates were randomly divided into four groups: group A (n=30), which included neonates with nonhemolytic indirect hyperbilirubinemia who received UDCA 10 mg/kg/day beside the usual phototherapy; group B (n=30), which included neonates with isoimmune hemolytic indirect hyperbilirubinemia who received UDCA 10 mg/kg/day, besides the usual phototherapy; group C (n=30), which included neonates with nonhemolytic indirect hyperbilirubinemia who received phototherapy only; and group D (n=30), which included neonates with isoimmune hemolytic indirect hyperbilirubinemia who received phototherapy only. The total serum bilirubin (TSB) was determined every 24 h till being less than 10 mg/dl.

Results
TSB was significantly decreased in group A compared with group C (P<0.05). However, TSB was comparable in groups B and D (P>0.05). Duration of phototherapy was significantly shorter in groups A and B compared with groups C and D (P<0.05).

Conclusion
UDCA shows a beneficial added role in the treatment of neonatal indirect hyperbilirubinemia, particularly in the nonhemolytic type.
Pre-emptive analgesic effect of ultrasound-guided quadratus lumborum block versus transversus abdominis plane block in laparoscopic cholecystectomy
Authors: Amer Dina A. , Abo Elnasr Lobna M. , Ezz Hoda A. , Abdullah Mohammed A. 
Published: February 2023

Background
Transversus abdominis plane (TAP) block creates satisfactory somatic analgesia at T6–L1 with minimal or no visceral blockade, whereas quadratus lumborum block (QLB) provides somatic and visceral analgesia of the whole abdomen.

Aim
To compare the efficacy of QLB with TAP block in controlling pain after laparoscopic cholecystectomy.

Patients and methods
A total of 70 patients with American Society of Anesthesiologists I and II, aged 18–50 years, who underwent elective laparoscopic cholecystectomy were allocated into two groups: group I (subcostal TAP block) and group II (lateral QLB).

Results
Pain scores were lower in group II compared with group I at 4, 6, 8, and 10 h postoperatively. The time of first rescue analgesia was prolonged in group II in comparison with group I. Heart rate and mean arterial pressure showed insignificant differences between the two groups intraoperatively. However, there was a significant decrease in heart rate and mean arterial pressure in group II compared with group I at 4, 6, 8, and 10 h postoperatively. There was no reported local anesthetic toxicity or technique-related complication in the two groups.

Conclusion
Bilateral ultrasound-guided QLB was more effective than bilateral ultrasound-guided subcostal TAP block in patients undergoing laparoscopic cholecystectomy with prolonged postoperative analgesia and less pethidine consumption.
Regional University Access
Authors: Eversole Robyn 
Published: February 2023

Access to appropriate training is a key to developing human resource is and enhancing quality of life in regional areas. Yet like many other service providers, universities are faced with the high costs of delivering services in regions with a small and scattered client pool. Thus, the challenge: how can universities serve regional communities and promote regional development while remaining cost effective and sustainable? Distance education technologies appear to offer a solution yet they may fail to respond to the underground needs of regional students.
In late 2000, Edith Cowan University commissioned a study to consider the challenge of regional service delivery, in the context of Warren-Blackwood region of South West Australia. This isolated, in land region has been undergoing economic displacement in the wake of timber industry restructuring; Improved training access has been identified as a regional development priority (Warren-Blackwood Action Plan, 2000) this paper presents the results of the study examining the demand for, and delivery of, university services in the Warren Blackwood region.
Surveys, focus groups and interviews with students and former students highlighted key trends, such as the pre university (year 10) exodus of youth from the region and the tendency for regionally based students to be mature aged. The paper identifies challenges, both logistical and psychological facing people who undertake long distance university studies (whether as distance-ed or commuting students). Finally, the paper suggests low-cost ways to facilitate the learning experience of students based in regional areas, by understanding the culture of learning and providing access to basic support resource is, regardless of the technological sophistication of course delivery.
Pengaruh Lingkungan Kerja Serta Motivasi Kerja Terhadap Kepuasan Kerja PT. SKF Indonesia
Authors: Rosa Dela , Rianto Muhammad Richo 
Published: February 2023

Setiap organisasi pemerintah, baik besar maupun kecil, perlu menjadi lebih efektif dan efisien. Faktor manusia perlu diperhitungkan dalam manajemen agar efeknya konsisten dengan apa yang diharapkan organisasi atau bisnis untuk mencapai tujuan yang telah ditetapkan sebelumnya. Ketika seseorang dapat menemukan potensi mereka untuk pekerjaan melalui pekerjaan mereka, mereka terus bekerja dengan antusias. Kepuasan kerja karyawan merupakan faktor penting dalam kesejahteraan karyawan, kedisiplinan, dan kinerja mereka dalam bekerja, yang semuanya mendukung tujuan perusahaan. Tujuan dari penelitian ini adalah untuk memahami lingkungan kerja dan motivasi yang berhubungan dengan praktik perekrutan karyawan di PT. SKF Indonesia..
Kata kunci : Lingkungan kerja, motivasi kerja, kepuasan kerja karyawan
FAST SOCIETY: THREE CASES OF THE PANIC ATTACK
Authors: NEDELCU Marcel 
Published: February 2023

All aspects of our life are ruled by the concept of „fast society” - from fast food to „fast (on-line) relationships” and, in turn, to „fast therapy”. Clients and counsellors alike are in a rush to find a quick way to solve the problem. This approach to „panic attack” problems could sometimes lead to a dead end. What is more, this dynamic of the therapeutic process could increase the client’s confusion and let the sensation of fear unexplained. The following paper puts forward three case studies, where the „not-knowing” position of the therapists unlocks the situation, helping the clients become aware of the elements from context that are connected to their fear. The meanings behind the attacks are revealed in the conversational field when the therapist stops their search for explanations and becomes patient enough to be curios and invite the client to explore detailed stories of their daily life.
”BUCURIA” - A NEW HOME, A NEW CHANCE - FOR YOUNG PEOPLE WHO LEAVE THE SPECIAL PROTECTION SYSTEM IN THE MUNICIPALITY OF IAȘI
Authors: MUNTEANU Luminița ,   COTOMAN Simona , DANILOV  Cristina 
Published: February 2023

At the level of the Municipality of Iași, the „Bucuria” Multifunctional Destination Social Center of the Directorate of Social Assistance Iasi constitutes a viable solution for the protection and for the preparing for independent living and for prevention and combat the risk of the young people whish is in need not to becoming homeless or socially marginalized persons.
Officially opened on September 26, 2014, the center operates with a capacity of 26 places in residential mode and 49 places in day mode. Residential services are provided free of charge, at demand, for a fixed period, depending on the particular situation of each beneficiary and in relation to his individual needs, in accordance with minimum quality standards for the social services centers with accommodation, organized as residential centers for young people who leave the child protection system applicable to this social center. Young people are encouraged and supported to participate in daily activities and get involved in household activities. At the same time, they are guaranteed access to the programs of social integration/reintegration, are supported to restore/strengthen the link with family of origin and extended family, with friends, as well as for (re)integration into community, they are guided on the labor market and their access to courses is facilitated.