bluuebunny/crossref_metadata_2025_split huggingface dataset:
The probability of achieving remission after correction of therapy in patients with pharmacoresistant focal epilepsy
Authors: Firsov K. V. , Kotov A. S. , Amirchanyan M. G. 
Published: July 2023

Drug-resistant forms of epilepsy are an important medical and social problem.Goal of the work. Evaluation of the probability of achieving remission after correction of therapy in patients with drug-resistant focal epilepsy.Material and methods. The study included 309 patients divided into three heterogeneous groups: a group of patients with focal pharmacoresistant epilepsy; a group of patients with super refractory focal epilepsy; control group – patients who had not previously received treatment. The examination included history taking, clinical and neurological examination, routine EEG and/or EEG video monitoring, MRI of the brain, and analysis of medical records. Therapy was adjusted.Results. After correction of therapy, remission in patients in Group 1 was achieved in 27.8% of patients, improvement – in 27.1%, no effect – in 45.1%; in Group 2, remission was achieved in 13.2% of patients, improvement – in 28.6%, no effect – in 58.2%; in Group 3, remission was achieved in 41.2% of patients, improvement – in 32.9%, no effect – in 25.9%. Negative prognostic factors did not show a significant correlation with the lack of effect of therapy.Conclusion. After correction of therapy, remission was achieved in several patients with drug-resistant focal epilepsy, while negative prognostic factors do not exclude the possibility of achieving remission.
Сognitive impairment in patients with chronic obstructive pulmonary disease
Authors: Kopylova A. P. , Zakharov V. V. , Vakhnina N. V. 
Published: July 2023

We conducted a systematic review of 23 original studies published from 2010 to 2022, which participated a total of 168 thousand people, including 48 thousand patients with chronic obstructive pulmonary disease (COPD) aged 45 to 93 years.Results. The prevalence of cognitive impairment (CI) in patients with COPD varies from 6 to 63%. COPD patients have a higher risk of developing mild CI (HR from 1.1 to 1.9; OR from 1.4 to 2.4) and dementia (HR from 1.3 to 1.9; OR = 1.2). The risk of cognitive dysfunction increases along with a decrease in the values of forced expiratory volume in one second as a percentage of its expected value (FEV1%) (OR = 1.34), arterial oxygen partial pressure (PaO2) (OR = 5.45), oxygen saturation (SaO2) and an increase in the level of arterial carbon dioxide partial pressure (PaCO2). There is a significant direct relationship between FEV1% and Mini-Mental State Examination (MMSE) (p < 0.0001) and an inverse relationship between COPD severity and MMSE (p < 0.0001). The MMSE score is correlated with FEV1% (r = 0.46, p < 0.01) and PaO2 (r = 0.43, p < 0.05).Conclusion. The available data confirm the association of COPD with an increased risk of occurrence and progression of CI. It is discussed that this is due to the unfavorable course of concomitant vascular and neurodegenerative diseases against the background of chronic hypoxia.
Kinesiotherapy in chronic back pain and combined tension type headache
Authors: Golovacheva A. A. , Golovacheva V. A. 
Published: July 2023

Kinesiotherapy is eff ective in the treatment of chronic nonspecific back pain (CNBP), but its eff ectiveness in tensiontype headache (TTH) is unclear. The effectiveness of kinesiotherapy in patients with CNBP and comorbid TTH has been little studied.The aim of the study was to evaluate the effectiveness of kinesiotherapy in patients with CNBS and comorbid TTH. Patients and methods. 52 patients (22 men and 30 women, mean age 32.4 ± 7.5 years) with CNBP and combined TTH were included in the study. All patients received standard treatment, of which 28 patients received kinesiotherapy (Group 1) and 24 patients were included in the comparison group (Group 2). All patients used pain diaries. All patients were tested by using the Beck Anxiety Inventory, the Beck’s Depression Inventory, the Pain Catastrophization Scale, the Kinesiophobia Scale, the Oswestry Disability Index, the Roland–Morris Disability Questionnaire, the Headache Impact Test 6, numerical pain rating scale before treatment and 3, 6 months after treatment. Clinical effcacy was assessed by reducing the frequency and intensity of headache (by ≥ 50%), back pain (by ≥ 30%), and by increasing functional activity during the day (by ≥ 30%).Results. At 6 months follow-up signifiantly more patients in group 1 than in group 2 achieved a clinical effect on TTH and CNBP: 78.5% (n = 22) compared to 41.7% (n = 10); OR (95% CI) = 1.99. In 9 patients (32%) of group 1, a complete remission of TTH and CNBP was noted, in group 2 there were no such patients. At 6 months follow-up group 1 showed a significant improvement (p < 0.05) in comparison with group 2 in terms of functional activity and emotional state.Conclusion. Kinesiotherapy for CNBP and combined TTH is effective both for back pain and headache. It increases functional activity and improves the emotional state of patients.
ОГЛЯД МАТЕМАТИЧНИХ ТА АЛГОРИТМІЧНИХ МЕТОДІВ СИСТЕМ АВТОМАТИЧНОГО КЕРУВАННЯ БАГАТОЦІЛЬОВОГО АВТОНОМНОГО БЕЗПІЛОТНОГО ПІДВОДНОГО АПАРАТА ІЗ СКЛАДНОЮ ДИНАМІКОЮ РУХУ
Authors: ГУРИНЕНКО Станіслав , БУРАУ Надія 
Published: July 2023

У роботі розглянуті джерела, праці та дослідження математичних та алгоритмічних методів і підходів до розробки систем керування багатоцільовими автономними безпілотними підводними апаратами. Показано, як реалізується та впроваджується забезпечення автоматичного керування в умовах складної динаміки руху апарата, за допомоги різних підходів, алгоритмів та методів керування.
Представлено та наведено опис робіт та праць за останні 10-15 років в області математичного та алгоритмічного методів автоматичного керування рухомими об’єктами, що працюють та діють у водному та підводному середовищах. Розглянуто досвід вирішення питань автоматичного керування, як теоретичного так і практичного аспектів. Досвід останніх десятиліть показав різноманітні підходи та методи, проте дослідження систем керування відбувається на основі базових знань про об’єкт, а також, у більшості випадків, при проведені досліджень систем керування не розглядається конструктивні особливості апарата, характер руху апарата та завдання, які ставляться перед апаратом. Враховуючи попередній досвід та проведені дослідження у даній тематиці пропонується підхід інтегрованого та комплексного дослідження системи автоматичного керування, яка видає сигнали керування враховуючи не тільки динаміку руху апарата, а і конструкційні особливості апарата, гідродинамічні параметри, які залежать від конструкції апарата, просторове положення апарата, яке уточнюється системою орієнтації та навігації, застосування вихідної інформації системи орієнтації та навігації, як інформації зворотного зв’язку для уточнення коефіцієнтів керування та покрашення точності та якості керування.
Проаналізовано актуальні роботи в області автоматичного керування багатоцільовими маневровими автономними безпілотними підводними апаратами зі складною динамікою. Проведено критичний аналіз проблематики керування багатоцільовими автономними безпілотними підводними апаратами зі складною динамікою та представлено спосіб покращення існуючих методів керування багатоцільовими підводними апаратами зі складною динамікою.
The MSH2 c.793-1G>A variant disrupts normal splicing and is associated with Lynch syndrome
Authors: Li Yiming , Yu Lulu , Cui Jiajia , Yin Jiye , Wu Wei 
Published: July 2023

InstructionLynch syndrome (LS) is the most common inherited cancer predisposition disorder of colorectal cancer (CRC) which is associated with pathogenic variants in 4 mismatch repair (MMR) genes. Here, we reported a multi-generation Chinese family clinically diagnosed with LS.MethodsTo identify the underlying pathogenic gene variants, 30 whole blood samples and 4 colorectal cancer tissue samples and their clinical data were obtained from this four-generation family. Microsatellite instability-high (MSI) testing, immunohistochemistry (IHC), and Whole-Exome Sequencing (WES) were performed to identify the MMR/MSI and the underlying gene variants. The minigene splicing assay and in vitro splicing assay were used to explore the function of this variant.ResultsMSI-H and dMMR was revealed by the MSI testing and IHC, Whole-Exome Sequencing (WES) in 3 patients successfully identified a splicing variant (c.793-1G&gt;A) in intron 4 of MSH2. Sanger sequencing validated the WES results, and all the “healthy” individuals carrying the variant have been identified in the family by PCR. Bioinformatics analysis and in vitro minigene assay showed that the pathogenic variant affected the splicing process of MSH2 gene to generate 2 kinds defective transcription products, and consequently reduced the expression of MSH2 protein. The mutation carriers were later recommended for colonoscopy and other important cancer diagnostic inspections every 1-2 years because they both have a higher risk of LS.DiscussionWe found a pathogenic splicing variant (rs863225397, c.793-1G&gt;A) of MSH2 gene, and furtherly confirmed that this mutation plays an important role in LS patients of this pedigree based on the vitro study. Our study indicates that one splicing mutation in the MSH2 gene (c.793-1G&gt;A) causes LS and highlights the importance of LS gene testing.
Clinicopathological characteristics and postoperative prognosis of patients with nuclear pedigree of esophageal squamous cell carcinoma
Authors: Wei Meng Xia , Song Xin , Zhao Xue Ke , Han Wen Li , Bao Qi De , Han Xue Nan , Xu Rui Hua , Li Xin Min , Fan Zong Min , Wang Ran , Li Xing Song , Hu Jing Feng , Li Jia , Li Bei , Tan Hui Fang , Gao She Gan , Zhou Fu You , Wang Li Dong 
Published: July 2023

The aim of this work is to analyze the clinicopathological characteristics and prognostic factors of patients with nuclear pedigree of esophageal cancer. The clinicopathological data and follow-up information of 3,260 patients from different nuclear pedigree of esophageal cancer who underwent radical resection of esophageal cancer were collected, and the clinicopathological characteristics and prognostic factors of the patients were analyzed. The male to female ratio of 3,260 patients with esophageal cancer was 1.7:1. The diagnosis age was ranged from 32 to 85 (60.2 ± 8.1) years old. About 53.8% of the patients were ≥ 60 years old; About 88.8% of the patients came from the high incidence area of esophageal cancer; About 82.5% of the tumors were located in the middle and lower segments of esophagus; Poor, moderate and well differentiation accounted for 26.6%, 61.9% and 11.5% respectively; The surgical margin accounted for 94.3%; 47.6% of the tumors were shorter than 4 cm in length; Clinicopathological TNM stage (0+I) accounted for 15.2%, and stage II, III and IV accounted for 54.5%, 29.9% and 0.4%, respectively. Cox analysis showed that male, diagnosed age ≥ 60 years, tumor located in neck and upper esophageal segments, poor differentiation, tumor length ≥ 4 cm, and advanced TNM were independent risk factors for the prognosis of patients in nuclear pedigree with esophageal cancer. Gender, diagnosis age, tumor location, degree of differentiation, tumor length and TNM stage are the influencing factors for the prognosis of patients with nuclear pedigree of esophageal cancer, which will provide important data for the future study of esophageal cancer family aggregation.
The core self-evaluations, psychological capital, and academic engagement: a cross-national mediation model
Authors: Paloș Ramona , Samfira Elena Mirela , Vîrgă Delia , Purić Daliborka 
Published: July 2023

IntroductionAn academic environment with continuously more demanding tasks requires students to capitalize on their strengths to meet the challenges and engage in learning experiences. Engaged students are deeply involved in their work, are strongly connected with their studies, and are more successful in academic tasks. The present study aimed to test a model in that core self-evaluations (CSE) predicts academic engagement (AE) directly and indirectly by increasing personal resources (i.e., psychological capital; PsyCap) in the case of two different samples, Romanian and Serbian.MethodsData were collected through three online questionnaires from 672 undergraduate students (Romania – 458; Serbia – 214).ResultsThe findings confirmed that CSE was positively related to PsyCap, which was positively associated with AE, and PsyCap mediates the relationship between the two variables in both samples. A positive evaluation of one’s characteristics (high CSE) mainly affects the cognitive and emotional mechanism of appraising the academic-related tasks one encounters (high PsyCap), ultimately shaping their motivation and engagement.DiscussionThese results pointed out the importance of the CSE and PsyCap that support each other and increase students’ AE, explaining the mediating mechanism of PsyCap. Also, they provide insight into the students’ engagement from two different cultural and educational contexts, being helpful to universities in their effort to increase students’ engagement.
New Minerals from the Redmond Mine, North Carolina, USA: III. Cherokeeite and Cuprocherokeeite, Two New Minerals Containing [Pb2(Zn,Cu2+)(OH)4]2+ Chains
Authors: Kampf Anthony R. , Smith Jason B. , Hughes John M. , Ma Chi , Emproto Christopher 
Published: July 2023

AbstractThe new minerals cherokeeite, [Pb2Zn(OH)4](SO4)·H2O (IMA2022-016), and cuprocherokeeite, [Pb8Zn3Cu2+(OH)16](SO4)4·4H2O (IMA2022-086), were found in the Redmond mine, Haywood County, North Carolina, USA, where they occur together in a highly unusual secondary assemblage that comprises a variety of rare Pb-Zn-Cu sulfates, thiosulfates, and carbonates. Cherokeeite has the following properties: colorless to pale pink prisms or blades to about 1 mm; white streak; vitreous luster; brittle; Mohs hardness 2½; splintery fracture; at least two perfect cleavages; 5.011 g/cm3 calculated density; biaxial (+) with α = 1.745(5), β = 1.770(5), γ = 1.805(5), and 2V = 85(2)°. Cuprocherokeeite has the following properties: light blue prisms or blades to about 1 mm; very pale bluish-white streak; vitreous luster; brittle; Mohs hardness 2½; irregular, curved fracture; probably two good cleavages; 5.032 g/cm3 calculated density; biaxial (+) with α = 1.760(5), β = 1.770(5), γ = 1.800(5), and 2V (meas.) = 65(3)°. Electron probe microanalyses provided the empirical formulae [Pb2.00Zn1.00(OH)4](SO4)0.85(S2O3)0.15·H2O and [Pb8.14(Zn2.52Cu2+1.34)(OH)16][(SO4)3.07(S2O3)0.93]·4H2O for cherokeeite and cuprocherokeeite, respectively. Cherokeeite is monoclinic, P21/n, a = 17.1697(7), b = 6.47173(19), c = 17.5304(12) Å, β = 115.440(8)°, V = 1759.06(19) Å3, and Z = 8. Cuprocherokeeite is monoclinic, P21/n, a = 12.6828(5), b = 9.4629(5), c = 14.7876(8) Å, β = 94.798(4)°, V = 1768.53(15) Å3, and Z = 2. The structures of cherokeeite (R1 = 0.0425 for 2681 I &gt; 2σI) and cuprocherokeeite (R1 = 0.0741 for 2411 I &gt; 2σI) both contain edge-sharing chains of octahedra decorated by Pb2+ cations, which are strongly bonded to the chains via short Pb–O bonds. In cherokeeite, the octahedral cations are all Zn, whereas in cuprocherokeeite, one in every four cations is Cu2+.
Who are the members of the accreditation commissions? Portrait, requests and expectations
Authors: Ripp T. М. , Iminov N. М. , Zverev A. S. , Yegorova V. S. , Konenkova N. В. , Ripp E. G. 
Published: July 2023

Primary accreditation of specialists plays a key role in the growth of young doctors. The members of the accreditation subcommittees (ASC) occupy an important place in the process of primary accreditation. The purpose of this pilot single-center prospective research with anonymous questionnaires was to study aspects of the work and training of ASC members in order to develop a reasonable design of a multicenter research to study the “portrait” of an ASC member in order to subsequently form a request for the members preparation of subcommittees and develop practical recommendations for effective interaction between the accreditation site and ASC members. The questionnaires of 27 members of the subcommittees were analyzed. The pilot study reviewed the duration of participation in the work of the ASC, ways of preparing for work as experts and readiness to undergo additional training, satisfaction with the training of accredited medical students. In addition, opinions were taken into account on the quality and the need to correct the passports of stations of an Objective Structured Clinical Examination (OSCE), optimize the work schedule during the period of accreditation of specialists, as well as proposals for improving, increasing the efficiency and coordination of the work of the ASC with accreditation sites. The pilot project aroused serious interest among the participants of the XI Congress of the Russian Society for Simulation Education in Medicine (ROSOMED) and the international conference 2022 in Moscow. The reason is this study showed the importance of taking into account the opinions of members of the ASC, as direct participants in the accreditation process, which makes it possible to develop the design of a multicenter international study, the data of which will make it possible to offer evidence-based recommendations to improve the interaction between participants in the accreditation process in medicine and improve its quality in the Russian Federation, with a possible broadcast on the territory of the interested countries participating in the study.
A Ten-Year Review of the Management of Medical Patients in the Intensive Care Unit in a Resource-Poor Setting in Southern Nigeria
Authors: Victor Abhulimen , Ayanate Oruobu-Nwogu 
Published: July 2023

Purpose: The Intensive Care Unit (ICU) is a specialist ward within a hospital, with a concentration of expertise and resources for the management of critically ill patients. Some clinicians think of the ICU only in relation to surgical practice, maybe because many intensivists are anaesthesiologists and anaesthesia is closely linked to surgery. However, this notion may not be entirely true. This study aims to highlight the importance of the ICU to patients with medical challenges.
Methodology: This is a ten-year retrospective study conducted at the University of Port Harcourt Teaching Hospital. Ethical approval for the study was sought and gotten from the hospital’s ethical committee. All patients who were admitted into the ICU with medical diagnosis were included in this study. The information gotten includes history, age, sex, diagnosis, length of admission, and outcome. The data collected was analyzed and presented in tables and charts.
Findings: The mean age was 51.41±20.12. The highest age was 95 years. The mean bill paid was 80,718.55 Naira and the largest bill paid was 605,500 Naira while the least bill paid was 2000. The mean duration of stay was 6.59 days and ranged from a day to 120 days. The males were 268 (51.8%) while the females were 249(48.2%). Two hundred and sixty-five patients (51.3%) died during the study period. Patients who were transferred out of the ICU spent the highest amount of money and spent the most time (10.19 days) in the ICU. The patient who died spent the least amount of time (4.56 days) in the ICU. A hundred and two patients were discharged from the ICU. Transferring them to a high dependency unit or ward will save cost. As the age increased, the comorbidities also increased with 309 out of 517 having comorbidities. Exacerbation of comorbidity led to admission in the ICU.
Recommendation: Medical patients admitted into the ICU tend to have a higher mean age and have a higher mortality rate. Older patients tend to have more comorbidity. Proper and effective management of the ICU will save cost. Proper management of comorbidities in older patients can lead to an improvement in health. Patients who are fit, could be transferred to other wards and discharged from there, this will free up beds in the ICU, increase effective use of the ICU and save cost.
Automatic Water Quality and Fish Feed Monitoring System in Aquarium Using LORA
Authors: Ilmi Muhammad Fariz , Syahrorini Syamsudduha , Ayuni Shazana Dhiya 
Published: July 2023

Keeping ornamental fish, especially guppies, is a type of ornamental fish that is widely kept because it has a very beautiful color pattern. The growth of guppies is influenced by environmental factors, including water temperature, water pH, and water turbidity. Fish feed is also a very important factor in the survival of fish. In general, the ideal temperature that can make guppies develop well between the range of 23-27 °C, the pH of the water is in the range of 6-8 pH. and the turbidity of guppy water requires a water turbidity level of 0-25 NTU.
The purpose of this study is to design and create a water quality monitoring system in guupies using LoRa and automatic feeding according to realtime. The hardware used is Arduino Uno as a microcontroller, LoRa SX1278 as long-distance communication, Turbidity Sensor, DS18B20 temperature sensor, water pH sensor as LCD 16x4, RTC, Relay, Water pump. The system created can monitor the water temperature, water turbidity level, and Ph of aquarium water automatically. Testing is carried out by detecting the quality of aquarium water with all sensors simultaneously to determine the condition of the water which will later be monitored using LoRa. The test results determine if the water state is cloudy with a range of >2000 NTU, the water pump will automatically turn on until the water state reaches the range of <2000 NTU.
Gambaran Unsafe Action Pada Pekerja Keramik M di Proyek R
Authors: NS Aninditya 
Published: July 2023

Berdasarkan data ILO tahun 2013, 1 pekerja di dunia meninggal sampai 15 detik karena kecelakaan kerja dan 160 pekerja mengalami sakit akibat kerja. ILO mencatat angka kematian dikarenakan kecelakaan dan penyakit akibat kerja sebanyak 2 juta kasus setiap tahun. Setiap jam sedikitnya terjadi satu kasus kecelakaan kerja di Indonesia (Kesehatan, 2014). Sedangkan, data BPJS ketenaga kerjaan menunjukan pada akhir 2015 terdapat 105.182 kasus insiden kerja dengan korban meninggal mencapai 2.375 orang (BPJS, 2016). Penelitian ini menggunakan metode penelitian analitik kuantitatif dilakukakan di Lokasi R tahun 2022. Populasi sebanyak 50 responden maka penulis mengambil semua sampelnya. Variabel independen yang diteliti adalah umur responder, tingkat pendidikan, kepatuhan, dan sikap pekerja.Hasil penelitian ini berdasarkan hasil wawancara dan pengisian kuesioner dimana hamper semua responden 70% sudah memiliki tingkat pengetahuan mengenai safety dnegan baik, dan hanya 15 responden saja yang tingkat pengetahuannya rendah. Untuk umur pekerja sebanyak 30 respondeen yang berusia tua sedangkan yang muda hanya 20 responden, sementara tingkat kepatuhannya cukup baik sebanyak 37 rsponden dan yang tidak baik hanya 13 responden. Yang terakhir untuk sikapnya sudah 42 responden yang memiliki sikap yang baik dalam hal safety ditempat kerja dan hanya 8 respinden saja yang memiliki sikap tidak baik., Kesimpulannya ada hubungan antara umur responden, tingkat pendidikan, kepatuhan serta sikap pekerja dengan pemahaman serta kepatuhan terhadap SOP di Proyek R ini.
Kata Kunci : Keselamatan dan Kesehatan Kerja; Unsafe Action; alat pelindung diri