bluuebunny/crossref_metadata_2025_split huggingface dataset:
From early birds to night owls: a longitudinal study of actigraphy-assessed sleep trajectories during the transition from pre- to early adolescence
Authors: Boatswain-Jacques Anna-Francesca , Dusablon Charlotte , Cimon-Paquet Catherine , YuTong Guo Élie , Ménard Rosalie , Matte-Gagné Célia , Carrier Julie , Bernier Annie 
Published: April 2023

Abstract

Study Objectives
Pre- and early adolescence are believed to constitute periods of important age-related changes in sleep. However, much of the research on these presumed developmental changes has used cross-sectional data or subjective measures of sleep, limiting the quality of the evidence. In addition, little is known about the development of certain features of the sleep–wake cycle pertaining to regularity (e.g. weekend–weekday differences and intra-individual variability) or circadian rhythms (e.g. sleep midpoint).

Methods
This study examined the sleep trajectories of 128 typically developing youth (69 girls) from ages 8 to 12 years on four sleep characteristics: sleep onset, sleep offset, total sleep time (TST), and sleep midpoint. For each of these characteristics, actigraphy-derived estimates of typical (i.e. mean) sleep and sleep regularity were obtained at each time point. Multilevel growth curves were modeled.

Results
Overall, the sleep–wake cycle significantly changed between 8 and 12 years. Mean sleep onset, offset and midpoint exhibited an ascending curvilinear growth pattern that shifted later with age, while mean TST decreased linearly. Weekend–weekday differences (social jetlag) for sleep offset and midpoint became more pronounced each year. Weekday TST was longer than weekend TST, though this difference became smaller over time. Finally, intra-individual variability increased over time for all sleep characteristics, with variability in TST ascending curvilinearly. Important between-person and sex differences were also observed.

Conclusion
This study reveals the marked changes that occur in the sleep of typically developing pre- and early adolescents. We discuss the potential implications of these trajectories.
What Makes Life Meaningful? Combinations of Meaningful Commitments Among Nonreligious and Religious Americans
Authors: Edgell Penny , Miller Mahala , Frost Jacqui 
Published: April 2023

Abstract
Having a sense that one’s life is meaningful is related to, but distinct from, happiness, satisfaction, or living a moral life. Scholars across disciplines have investigated the role of religion in providing meaning or questioned whether religious decline prompts a crisis of meaninglessness. We use national survey data (2019, N = 1,326) to identify the overall patterns in what people find meaningful in general and how they spend time in activities understood as meaningful. We find five bundles of meaningful commitments: three focused on relationships, including one focused on a variety of family and friend relationships, one anchored by a relationship with a partner, and one anchored by a relationship with a child; one focused on ideals and lifestyle; and one that is less specialized but more prone to focus on religious commitment. We find three bundles of meaningful practices, the things people do in their daily lives that they understand as meaningful: one focused on relationships, one focused on ideals and lifestyle, and one that is less specialized but more prone to focus on religious commitments. We analyze how each bundle is associated with happiness and well-being, and how religious and nonreligious identification shape who embraces which bundle. In the conclusion, we discuss the benefits of our approach and suggest directions for future research.
Research on the navigational risk of liquefied natural gas carriers in an inland river based on entropy: A cloud evaluation model
Authors: Liu Chengyong , Li Shijie , Chen Shuzhe , Chen Qifan , Liu Kang 
Published: April 2023

Abstract
Due to the flammability and explosive nature of liquefied natural gas (LNG), an extremely strict process is followed for the transportation of LNG carriers in China. Particularly, no LNG carriers are operating in inland rivers within the country. Therefore, to ensure the future navigation safety of LNG carriers entering the Yangtze River, the risk sources of LNG carriers' navigation safety must be identified and evaluated. Based on the Delphi and expert experience method, this paper analyses and discusses the navigation risk factors of LNG carriers in the lower reaches of the Yangtze River from four aspects (human, ship, environment and management), identifies 12 risk indicators affecting the navigation of LNG carriers and establishes a risk evaluation index system. Further, an entropy weight fuzzy model is utilized to reduce the influence of subjective judgement on the index weight as well as to conduct a segmented and overall evaluation of LNG navigation risks in the Baimaosha Channel. Finally, the cloud model is applied to validate the consistent feasibility of the entropy weight fuzzy model. The research results indicate that the method provides effective technical support for further study on the navigation security of LNG carriers in inland rivers.
12th Japan-US Seminar in Plant Pathology Meeting Report
Authors: Sasaki Yumino , González-Tobón Juliana , Hino Yuta , Jin Chujia , Li Tianrun , Nguyen Tan Anh Nhi , Oakley Blake , Stevens Danielle 
Published: April 2023

The 12th iteration of the Japan-US Seminar in Plant Pathology was held in Ithaca, New York at Cornell University in the fall of 2022. Presentations covered a range of topics under the theme “Remodeling of the Plant-Microbe Environment During Disease, Defense, and Mutualism,” and the meeting included a panel discussion of best practices in science communication. This report presents highlights of the meeting, from the perspective of early career participants of the seminar. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
The Onset and Development of Patella Alta in Children With Patellar Instability
Authors: Patel Nikhil B. , Oak Sameer R. , Rogers Kelly , Crawford Eileen A. 
Published: April 2023

Background:
Patella alta is an anatomic risk factor for patellar instability in adolescents that is also linked to the risk factor of trochlear dysplasia. This study aims to determine the age of onset and age-related incidence of patella alta in a pediatric population of patients with patellar instability. We hypothesized that patellar height ratios would not increase with age, suggesting a congenital rather than the developmental origin of patella alta.

Methods:
A retrospective cross-sectional cohort of patients was collected with the following inclusion criteria: patients aged 5 to 18 who had a knee magnetic resonance imaging performed from 2000 to 2022 and the International Classification of Diseases code for patellar dislocation. Demographic information and details of the patellar instability episode(s) were collected with a chart review. Sagittal magnetic resonance imaging was used to measure Caton-Deschamps Index (CDI) and the Insall-Salvati Ratio (ISR) by 2 observers. Data were analyzed to assess for associations between patellar height ratios and age of the first dislocation and to assess if the proportion of patients categorized as having patella alta changed with age.

Results:
The 140 knees included in the cohort had an average age of 13.9 years (SD=2.40; range: 8–18) and were 55% female. Patella alta was present in 78 knees (55.7%) using CDI>=1.2 and in 59 knees (42.1%) using ISR>=1.3. The earliest age patella alta was observed was at age 8 using CDI>=1.2 and age 10 using ISR>=1.3. There were no statistically significant associations between CDI and age without adjustment (P=0.14) nor after adjustment for sex and body mass index (P=0.17). The proportion of knees above the CDI threshold for patella alta to the knees below the cutoff did not show a significant change with age (P=0.09).

Conclusions:
Patella alta, as defined by CDI, is seen in patients as young as 8 years old. Patellar height ratios do not change with age in patients with patellar dislocation, suggesting that patella alta is established at a young age rather than developing during the adolescent years.

Level of Evidence:
Level III–diagnostic, cross-sectional.
Accuracy of baseline low-dose computed tomography lung cancer screening: a systematic review and meta-analysis
Authors: Guo Lanwei , Yu Yue , Yang Funa , Gao Wendong , Wang Yu , Xiao Yao , Du Jia , Tian Jinhui , Yang Haiyan 
Published: April 2023

Abstract

Background:
Screening using low-dose computed tomography (LDCT) is a more effective approach and has the potential to detect lung cancer more accurately. We aimed to conduct a meta-analysis to estimate the accuracy of population-based screening studies primarily assessing baseline LDCT screening for lung cancer.

Methods:
MEDLINE, Excerpta Medica Database, and Web of Science were searched for articles published up to April 10, 2022. According to the inclusion and exclusion criteria, the data of true positives, false-positives, false negatives, and true negatives in the screening test were extracted. Quality Assessment of Diagnostic Accuracy Studies-2 was used to evaluate the quality of the literature. A bivariate random effects model was used to estimate pooled sensitivity and specificity. The area under the curve (AUC) was calculated by using hierarchical summary receiver-operating characteristics analysis. Heterogeneity between studies was measured using the Higgins I
2 statistic, and publication bias was evaluated using a Deeks’ funnel plot and linear regression test.

Results:
A total of 49 studies with 157,762 individuals were identified for the final qualitative synthesis; most of them were from Europe and America (38 studies), ten were from Asia, and one was from Oceania. The recruitment period was 1992 to 2018, and most of the subjects were 40 to 75 years old. The analysis showed that the AUC of lung cancer screening by LDCT was 0.98 (95% CI: 0.96–0.99), and the overall sensitivity and specificity were 0.97 (95% CI: 0.94–0.98) and 0.87 (95% CI: 0.82–0.91), respectively. The funnel plot and test results showed that there was no significant publication bias among the included studies.

Conclusions:
Baseline LDCT has high sensitivity and specificity as a screening technique for lung cancer. However, long-term follow-up of the whole study population (including those with a negative baseline screening result) should be performed to enhance the accuracy of LDCT screening.
Smartphone Dynamic Infrared Thermography for Harvesting AICAP Flap in a Large Breast-conservative Surgery
Authors: Vaccari Stefano , Lorenzano Valerio , Lisa Andrea , Di Giuli Riccardo , Klinger Marco , Klinger Francesco , Vinci Valeriano 
Published: April 2023

Summary:
Flaps based on perforators of the intercostal arteries have been described for the reconstruction of defects resulting from partial mastectomies. Dynamic infrared thermography (DIRT) identifies hot spots that accurately correspond to and evaluate perforator vessels toward the skin. The new generation of portable thermal cameras has become smaller, less expensive, more sensitive, and compatible with common smartphones. One option is the FLIR ONE system (FLIR Systems, Inc., Wilsonville, OR), a smartphone-compatible thermal camera. Despite its lower resolution, compared with the larger infrared camera models, it represents a viable option for thermal skin mapping, and its compact nature allows for easy portable use. The purpose of this article is to report a case of a preoperative study with smartphone DIRT used in the preparation of an anterior intercostal artery perforator–based flap for breast reconstruction after a wide resection at the level of the right infer-internal breast region, including a skin excision. Our study documents how smartphone DIRT is a rapid, sensitive, easily accessible and cost-effective diagnostic method for the topographical identification of intercostal artery perforators. It can be used as a rescue method at any stage of the intervention if it differs from the preoperative planning. It also confirms the proven usefulness of this flap for the reconstruction of partial defects in the breast and thoracic region.
Efficacy and Safety of Microsurgical Pharyngolaryngeal and Pharyngoesophageal Reconstruction: A Systematic Review of the Literature
Authors: Gasteratos Konstantinos , Vlachopoulos Nikolaos , Kokosis George , Goverman Jeremy 
Published: April 2023

Background:
Restoration of function and complication management after pharyngolaryngectomy remains a challenging task. The aim of our study was to compare the functional and clinical outcomes of pharyngolaryngeal and pharyngoesophageal reconstruction using free flaps, namely jejunal (FJF), anterolateral thigh, and radial forearm, and describe a reconstructive approach for these defects following tumor resection.

Methods:
We performed a systematic literature review on PubMed (Medline), Embase and Cochrane Library over the last two decades for articles reporting the surgical reconstructive modalities available after total or partial pharyngeal and/or laryngeal resection using a structured search strategy and strict inclusion and elimination criteria.

Results:
Our search identified a total of 677 articles, 112 full texts were fully reviewed for eligibility, and 39 met the inclusion criteria. The use of both FJF and fasciocutaneous flaps is safe. The FJF has optimal swallowing outcomes and a low incidence of major recipient-site complications. Nevertheless, free fasciocutaneous flaps exhibit comparable functional results, while they seem linked with fewer cases of perioperative mortality and flap failure. However, none of the currently available techniques can combine all potential benefits.

Conclusions:
Despite these procedures being mainly palliative in nature, the advent of microvascular techniques and utilization of fasciocutaneous free flaps has allowed optimal restoration of function combined with a reduced rate of perioperative and longterm complications. Both FJF and fasciocutaneous flaps can be viable treatment options, depending on the expertise of the surgeon and patient selection, to ensure the best outcomes.
Immune signatures in variant syndromes of primary biliary cholangitis and autoimmune hepatitis
Authors: Schultheiß Christoph , Steinmann Silja , Willscher Edith , Paschold Lisa , Lohse Ansgar W. , Binder Mascha 
Published: April 2023

Background:
Variant syndromes of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) share diagnostic features of both entities, but their immunological underpinnings remain largely unexplored.

Methods:
We performed blood profiling of 23 soluble immune markers and immunogenetics in a cohort of 88 patients with autoimmune liver diseases (29 typical AIH, 31 typical PBC and 28 with clinically PBC/AIH variant syndromes). The association with demographical, serological and clinical features was analyzed.

Results:
While T and B cell receptor repertoires were highly skewed in variant syndromes compared to healthy controls, these biases were not sufficiently discriminated within the spectrum of autoimmune liver diseases. High circulating checkpoint molecules sCD25, sLAG-3, sCD86 and sTim-3 discriminated AIH from PBC on top of classical parameters such as transaminases and immunoglobulin levels. In addition, a second cluster of correlated soluble immune factors encompassing essentially TNF, IFNγ, IL12p70, sCTLA-4, sPD-1 and sPD-L1 appeared characteristic of AIH. Cases with complete biochemical responses to treatment generally showed a lower level of dysregulation. Unsupervised hierarchical clustering of classical and variant syndromes identified two pathological immunotypes consisting predominantly of either AIH or PBC cases. Variant syndromes did not form a separate group, but clustered together with either classical AIH or PBC. Clinically, patient with AIH-like variant syndromes were less likely to be able discontinue immunosuppressive treatment.

Conclusions:
Our analyses suggest that variants of immune mediated liver diseases may represent an immunological spectrum from PBC to AIH-like disease reflected by their pattern of soluble immune checkpoint molecules rather than separate entities.
Wide variation in pre-procedural blood product transfusion practices in cirrhosis: a national multidisciplinary survey
Authors: Janko Natasha , Majeed Ammar , Clements Warren , Fink Michael A. , Lubel John , Goodwin Mark , Nicoll Amanda , Strasser Simone I. , Sood Siddharth , Bollipo Steven , Bate John , Bowers Kaye A , George Jacob , Kemp William , Roberts Stuart K. 
Published: April 2023

Background and Aims:
Recent guidelines recognize the limitations of standard coagulation tests in predicting bleeding and guiding pre-procedural blood component prophylaxis in cirrhosis. It is unclear whether these recommendations are reflected in clinical practice. We performed a nationwide survey to investigate pre-procedural transfusion practices and opinions of key health care stakeholders involved in managing cirrhosis.

Methods:
We designed a 36-item multiple-choice questionnaire to investigate the international normalized ratio and platelet cutoffs utilized to guide pre-procedural transfusion of fresh frozen plasma and platelets in patients with cirrhosis undergoing a range of low and high-risk invasive procedures. Eighty medical colleagues from all mainland States involved in managing patients with cirrhosis were invited by email to participate.

Results:
Overall, 48 specialists across Australia completed the questionnaire: 21 gastroenterologists, 22 radiologists, and 5 hepatobiliary surgeons. 50% of respondents reported that their main workplace did not have written guidelines relating to pre-procedural blood component prophylaxis in patients with cirrhosis. There was marked variation in routine prophylactic transfusion practices across institutions for the different procedures and international normalized ratio and platelet cutoffs. This variation was present both within and between specialty groups and held for both low and high-risk procedures. For scenarios where the platelet count was ≤ 50 × 109/L, 61% of respondents stated that prophylactic platelet transfusions would be given before low-risk and 62% before high-risk procedures at their center. For scenarios where the international normalized ratio was ≥2, 46% of respondents stated that prophylactic fresh frozen plasma would be routinely given before low-risk procedures and 74% before high-risk procedures.

Conclusion:
Our survey reveals significant heterogeneity of pre-procedural prophylactic transfusion practices in patients with cirrhosis and discrepancies between guidelines and clinical practice.
“Suddenly Feeling Dark”: A Qualitative Study on the Experiences of Nurses Facing Coworker Death During the COVID-19 Pandemic
Authors: SIGA TAGE Petrus Kanisius , AZI DJOGO Herliana Monika , LETOR Yulia M. K. , BINA Maria Yoanita 
Published: April 2023

ABSTRACT

Background
The coworkers of nurses who died because of COVID-19 infection generally experience a highly emotional grieving process. Nurses grieving the loss of a coworker during the COVID-19 pandemic experience higher psychological stress because of their high workload and the grueling shifts required to manage health emergencies during the pandemic and cope with long-standing staffing shortages. The limited number of studies discussing this issue has resulted in insufficient evidence necessary to develop effective counseling strategies and psychological support for nurses in Indonesia dealing with the massive waves of COVID-19 cases.

Purpose
This study was designed to elucidate the experiences of nurses across four provinces in Indonesia who had experienced the loss of a colleague during the COVID-19 pandemic.

Methods
A qualitative research design and phenomenological approach were used in this study. Sampling was done in Jakarta, Bali, East Java, and East Nusa Tenggara using purposive sampling for the first eight participants and snowball sampling for the subsequent 34 participants. Semistructured, in-depth interviews were used to collect data from 30 participants using appropriate ethical principles. Data saturation was achieved after interviewing 23 participants, and their data were analyzed using thematic analysis.

Results
Three main themes related to nurses' responses to the death of a colleague, distinguished into several stages, were identified. Stages in the first theme were as follows: (a) shocked to hear of colleague's death, (b) self-blame for failing to save a life, and (c) afraid to experience the same situation. Stages in the second theme were as follows: (a) make efforts to avoid the same thing from happening again, (b) develop strategies to avoid thoughts of loss, and (c) expect to have a psychological support system. Stages in the third theme were as follows: (a) seek new reasons, goals, directions, and meanings in life and (b) improve the physical and social health of individuals.

Conclusions/Implications for Practice
The range of responses from nurses to the death of a colleague during the COVID-19 pandemic identified in this study may be referenced by service providers to better provide psychological assistance and support to nursing staff. In addition, the coping strategies described by the participants provide detailed information that healthcare providers may use to deal with nurses facing death more comprehensively. This study emphasizes the importance of developing strategies to help nurses cope positively with their grief from a holistic perspective, which may be expected to impact positively the performance of nurses.
Benefits of an Integrated Nurse Residency Program in the Neonatal Intensive Care Unit
Authors: Waggoner Jacquelin K. , Waskosky Aksana 
Published: April 2023

Background:
The neonatal intensive care unit is a specialized unit where nurses, physicians, and other providers take care of the smallest patients in healthcare. Because neonatal intensive care units are highly specialized, many nursing students graduate from undergraduate programs with little experience or knowledge related to the care of neonatal patients.

Results:
Nursing residency programs with hands-on simulation training have been shown to provide significant benefits to new and novice nurses as they enter the workforce, particularly in areas where the patient population requires highly specialized treatment. The myriad of benefits provided by nurse residency programs and simulation training exercises have been shown to result in improved nurse retention, job satisfaction, nursing skill, and patient outcomes.

Conclusion:
Because of the proven benefits, integrated nurse residency programs and simulation training should be the standard for training new and novice nurses in the neonatal intensive care unit environment.
Teaching Professional Peer Review With the Use of Simulation
Authors: Cole Linda J. , Andrighetti Tia P. , Thrower Eileen J. B. , Engstrom Janet L. 
Published: April 2023

Background:
Quality improvement practices such as peer review and just culture are important components of patient safety initiatives, and health professions students should be introduced to these practices during their education.

Purpose:
The purpose of this study was to evaluate a peer-review simulation learning experience using just culture principles in a graduate-level, online nursing education program.

Methods:
The students rated their learning experience with high, positive scores in all 7 domains on the Simulation Learning Experience Inventory. Responses to the open-ended question indicated that the students thought the experience provided opportunities for deep learning, increased confidence, and enhanced critical thinking skills.

Conclusion:
A peer-review simulation program using just culture principles provided a meaningful learning experience for graduate-level students in an online nursing education program.