bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fotodokumentation von Verletzungen: rechtssicher ohne Rechtsmedizin?
Authors: Kono Naomi Miriam , Stockhausen Sarah , Giannoulaki Menexia , Engelmann Theresa Antonia , Wolff-Maras Roman , Debertin Anette Solveig 
Published: January 2023

Zusammenfassung
Hintergrund
Eine flächendeckende Verfügbarkeit von rechtsmedizinischen Leistungen besteht in Deutschland derzeit nicht. Dem gegenüber steht der Bedarf an gesellschaftlich gebotenen und aktuell sogar gesetzlich verankerten niederschwelligen Strukturen zur Spurensicherung und zur Beweisdokumentation. Vor diesem Hintergrund gewinnen Digitalisierung und telemedizinische Strukturen auch in der Versorgung von Gewaltbetroffenen immer mehr an Bedeutung. Der allgemeine technische Fortschritt ermöglicht hierbei die Vereinfachung von Dokumentation, Kommunikation, aber auch möglicher Manipulation von Befunden.

Fragestellung
Manipulationen können einerseits durch direkte Vortäuschung von Verletzungen auf dem Körper selbst, andererseits durch technische Bearbeitung am Bildmaterial vorgenommen werden und stellen die Zuverlässigkeit und Authentizität der Befunde infrage. Inwieweit können fotografische Selbstdokumentationen von vermeintlichen Verletzungen den forensischen Standards entsprechen, um als belastbares Beweismittel in ein Verfahren eingebracht zu werden und somit die rechtsmedizinische Untersuchung ersetzen?

Methoden
Anhand von Fallbeispielen aus der forensischen Routine, Selbstversuchen und digital mittels der Applikation Procreate® (Savage Software Group Pty. Ltd., Hobart, TAS, Australia) bearbeiteten Fotografien werden die Möglichkeiten, Grenzen und Fallstricke der Selbstdokumentation von Verletzungen diskutiert.

Schlussfolgerung
Mittels einfach im Internet zugänglicher Anleitungen und unkompliziert anzuwendender Verfahren ist die analoge und digitale Manipulation von Befunden ohne erheblichen Aufwand möglich. Aufgrund erstaunlich realistischer manipulierter Befunde sind Risiken im Hinblick auf rechtsstaatliche Verfahren bei der Beurteilung mitzudenken, insbesondere bei fehlenden verbindlichen Regelungen zur Validierung und zur Fehleranalyse digitaler Informationsverarbeitungsprozesse. Die Analyse zeigt, dass die direkte analoge Inaugenscheinnahme durch Rechtsmediziner_innen derzeit nicht zu ersetzen ist.
Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections
Authors: Mora-Bitria Laura , Asquith Becca 
Published: January 2023

AbstractKiller-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during pregnancy; the importance of KIRs in these NK-mediated processes is well-established. However, mounting evidence suggests that KIRs also have a prominent and long-lasting effect on the adaptive immune system. Here, we review the evidence for the impact of KIRs on T cell responses with a focus on the clinical significance of this interaction.
The exponential input-to-state stability property: characterisations and feedback connections
Authors: Guiver Chris , Logemann Hartmut 
Published: January 2023

AbstractThe exponential input-to-state stability (ISS) property is considered for systems of controlled nonlinear ordinary differential equations. A characterisation of this property is provided, including in terms of a so-called exponential ISS Lyapunov function and a natural concept of linear state/input-to-state $$L^2$$

L
2

-gain. Further, the feedback connection of two exponentially ISS systems is shown to be exponentially ISS provided a suitable small-gain condition is satisfied.
Identification of untrained class data using neuron clusters
Authors: Lee Young-Woo , Chae Heung-Seok 
Published: January 2023

AbstractConvolutional neural networks (CNNs), a representative type of deep neural networks, are used in various fields. There are problems that should be solved to operate CNN in the real-world. In real-world operating environments, the CNN’s performance may be degraded due to data of untrained types, which limits its operability. In this study, we propose a method for identifying data of a type that the model has not trained on based on the neuron cluster, a set of neurons activated based on the type of input data. In experiments performed on the ResNet model with the MNIST, CIFAR-10, and STL-10 datasets, the proposed method identifies data of untrained and trained types with an accuracy of 85% or higher. The more data used for neuron cluster identification, the higher the accuracy; conversely, the more complex the dataset's characteristics, the lower the accuracy. The proposed method uses only the information of activated neurons without any addition or modification of the model’s structure; hence, the computational cost is low without affecting the classification performance of the model.
The effect of narrative element incorporation on physical activity and game experience in active and sedentary virtual reality games
Authors: Lu Amy Shirong , Pelarski Victoria , Alon Dar , Baran Aleksandra , McGarrity Emma , Swaminathan Neha , Sousa Caio Victor 
Published: January 2023

AbstractNarratives are pervasive in video games and have been found to increase physical activity in active video games. However, the effect of incorporating narrative elements has seldom been examined in fully immersive virtual reality games. We investigated the effect of narrative element incorporation (between-subject: narrative vs. no narrative) in active virtual reality and sedentary virtual reality games (within-subject) and examined between- and within-subject effects on physical activity behavior, game experience, and physical activity engagement. We randomized 36 sedentary college students to either the narrative or the non-narrative group. All participants played an active virtual reality and a sedentary virtual reality game in counter-balanced order. Before each game session, they either watched a 5-min narrative video (narrative) or directly played the original virtual reality games without narratives (non-narrative). We collected participants’ physical activity data using wrist-worn accelerometers; we obtained their game experience and physical activity engagement via questionnaires. The narrative group spent a greater proportion of time in moderate-to-vigorous physical activity (%) and had less non-movement time during the active virtual reality gameplay than the non-narrative group (all p values < .05). The active virtual reality sessions induced a greater positive affect and greater physical activity engagement ratings than the sedentary virtual reality sessions. The incorporation of narrative elements in active virtual reality increased the relative time spent in moderate-to-vigorous physical activity and reduced non-movement time, compared to the non-narrative group. Active virtual reality encouraged more activity by participants and offered them a more enjoyable gaming experience in which they engaged more. Active virtual reality is a feasible physical activity promotion option among sedentary adults; the incorporation of narrative elements in active virtual reality helps increase relative moderate-to-vigorous physical activity and should be further explored for its efficacy.
When the owner does not know: comparing puppies and adult dogs’ showing behavior
Authors: Prato-Previde Emanuela , Pedretti Giulia , Terruzzi Elena , Valsecchi Paola 
Published: January 2023

AbstractDomestic dogs have been shown to engage in interspecific communication with their owners using a flexible repertoire of signals (i.e., gaze, vocalizations, and postures). This ability is influenced by ontogenetic development as well as breed selection. Different aspects of this phenomenon have been studied using the out of reach/hidden object task in which a piece of food is shown to the dog and then hidden in an unreachable spot by the experimenter. Dogs’ behavioral displays toward the target and the owner (ignorant about the location of the food) have been observed. The complex communicative behavior dogs exhibit in this context is defined as showing behavior and includes attention-getting components directed toward the owner, and directional components directed toward the target. No study has investigated the ontogenetic development of this behavior. In the current study, we compared the showing behavior in 4–6 month old puppies and 2–11 year old adults in an out of reach task involving the hiding of a food reward in one of two cabinets. Dogs were exposed to three conditions: (1) Owner with Food (OF), (2) Owner No Food (ONF), and (3) Alone with food (AF). Dogs showed more gaze alternations when both the food and the owner were present confirming the intentional and referential nature of this behavior. Contrary to our expectations, we found no differences between the showing behaviors of 4–6 month old puppies and adult dogs. This study provides interesting preliminary evidence of showing behavior in puppies. Further studies are needed to gain a deeper understanding of the factors influencing this communicative behavior (i.e., breed, level of training). Furthermore, longitudinal studies should be performed from the age of 2 months up to 1 and 2 years to better clarify the influence of development and experience on showing behavior in domestic dogs.
Transition to Preschool: Paving the Way for Preschool Teacher and Family Relationship-Building
Authors: Andersson Søe Martina , Schad Elinor , Psouni Elia 
Published: January 2023

AbstractBackgroundPrevious research suggests that interactions between preschool teachers and children in early care and educational contexts can contribute to the child’s positive attachment development and socioemotional adjustment.ObjectiveInvestigate how the transition process to preschool is organized and whether various ways of organizing it may differently influence family–teacher relationship-building and child adjustment.MethodsConducted a mixed methods study of quantitative and qualitative survey data from Swedish preschool professionals (N = 535).ResultsPreschool introduction varied across preschools in several structural aspects such as introduction length and intensity, timing for first child–parent separation, and number of children and teachers involved in the introduction process. Results moreover suggested that different introduction models were associated with different ways of engaging the parent, where the “parent-active” model was characterized by a high level of parental participation during the introductory activities. This was perceived by preschool professionals as positively influencing the family–teacher relational formation.ConclusionFindings suggest that inviting parents to participate actively in preschool transition may help better engage them in the introduction process, which in turn may positively influence family–teacher relationship-building. Future research should focus in more detail on how child–teacher and parent–teacher interactions, respectively, influence family–teacher relationship-building and child adjustment during, and after, the introduction period.
Surgeon experience in glioblastoma surgery of the elderly—a multicenter, retrospective cohort study
Authors: Pöppe Johannes P. , Machegger Lukas , Steinbacher Jürgen , Stefanits Harald , Eisschiel Sophie , Gruber Andreas , Demetz Matthias , Ladisich Barbara , Kraus Theo F.J. , Weis Serge , Spiegl-Kreinecker Sabine , Romagna Alexander , Griessenauer Christoph J. , Jahromi Behnam Rezai , Rautalin Ilari , Niemelä Mika , Korja Miikka , Schwartz Christoph 
Published: January 2023

Abstract
Purpose
To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis.

Methods
GBM patients aged ≥ 65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantified in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous five years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity).

Results
198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0–12.0); median EOR was 89.4%. Surgery-related morbidity affected 19.7% patients. No correlations of lifetime surgeon experience with OS (P = .693), EOR (P = .693), and surgery-related morbidity (P = .435) were identified. Adjuvant therapy was associated with improved OS (P < .001); patients with surgery-related morbidity were less likely to receive adjuvant treatment (P = .002). In multivariable testing, adjuvant therapy (P < .001; HR = 0.064, 95%CI 0.028–0.144) remained the only significant predictor for improved OS.

Conclusion
Less experienced neurosurgeons achieve similar surgical results and outcome in elderly GBM patients within the setting of academic teaching hospitals. Adjuvant treatment and avoidance of surgery-related morbidity are crucial for generating a treatment benefit for this cohort.
The Knowledge Content of the Greek Production Structure in the Aftermath of the Greek Crisis
Authors: Kanzola Anna-Maria 
Published: January 2023

AbstractContrary to the traditional approaches for the evaluation of human capital, this study proposes the assessment of human capital through its qualitative characteristics (knowledge, skills, abilities, and working activities). To investigate the knowledge content density in the Greek production structure for the year 2018, the methodology followed concerns a sectoral analysis of the economy and the matching of each occupation with four knowledge items from the O*NET database. The findings indicate that the prevailing knowledge characteristics (66% of total) of the Greek production structure of 2018 concern a simple rather than sophisticated knowledge background which is reflected in the economic structure and in middle and low specialization of the workforce. This study contributes to the literature by providing an original and robust way to evaluate the knowledge content in total within the economy without being based on model forecasts but sectoral data. Furthermore, it provides policymaking insights for the intervention in specific areas of the knowledge content which could “nudge” economic growth of the existing production structure. The grounds for policymaking concern education, reskilling, and especially lifelong learning programs.
Decoding the dance parameters of eastern honeybee, Apis cerana
Authors: Hu Zongwen , Miao Chunhui , Di Nayan , Zhou Chuntao , Zhang Yangyi , Yang Juan , Xun Lijie , Li Yahui 
Published: January 2023

AbstractBees dance to deliver food vectors that contain information regarding distance gauging and spatial orientation. The eastern honey bee, Apis cerana, also transmits this vector information through waggle dance. Although many reports have published on this topic, changes in dance parameters of A. cerana that occur at different distances are unclear. Herein, we filmed the bees’ foraging dance at different distances until the bees stopped collecting food, analyzed these videos frame by frame, and set a feeder in four cardinal directions to record the changes in bees’ dance with the azimuth of the sun. The duration and number of waggle runs of the dancers significantly correlated with the distance from hive to feeder. The dance parameter exhibited a linear model with distance. As the sun’s azimuth changed, the angle of the waggle run changed counterclockwise. We elucidate how to combine distance and direction to calibrate the spatial distribution of the resource location advertised by dance. Finally, we discuss the dance and navigation of long-distance collection and provide a basis for further understanding of the foraging ecological strategies of eastern honeybee.
A multifunctional bioresponsive and fluorescent active nanogel composite for breast cancer therapy and bioimaging
Authors: Ghomi Matineh , Zare Ehsan Nazarzadeh , Alidadi Hadis , Pourreza Nahid , Sheini Azarmidokht , Rabiee Navid , Mattoli Virgilio , Chen Xianfeng , Makvandi Pooyan 
Published: January 2023

AbstractBio-responsive nanocomposites with facile fabrication and rational design are of great importance in the diagnosis and treatment of cancer. Herein, the combination of bioimaging due to the presence of QD and controlled drug delivery via nanogel was employed for cancer treatment. To this aim, we fabricated a traceable and bioresponsive fluorescent active nanogel composite by integrating creatinine-functionalized carbon dots (QD) into a lecithin-inulin nanogel. Subsequently, PEGylation and integration of herceptin on the nanogel were carried out to improve the biofate and its ability to target HER2-positive breast cancer. The assessment of cellular uptake demonstrated that this nanogel was effectively internalized by SK-BR-3 cells and the production of reactive oxygen species was significantly boosted. Moreover, the nanogel composite led to high expression ofP53andBaxgenes along with a low expression ofBcl-2gene (as promotors of the apoptosis signaling pathway). The cellular uptake of herceptin was enhanced. It led to inhibiting the proliferation of the breast cancer cells as well as the reduction of viability of SK-BR-3 cancer cells (HER-2 positive) compared with MDA-MB-231 cells (triple-negative). The intraperitoneal injection of the developed formulation to MCF-7 breast cancer cell-bearing BALB/c mice supported the observation of tumor growth inhibition. Overall, herceptin-adorned PEGylated lecithin-inulin nanogel composite can be a promising theranostic candidate for targeting HER-2-positive breast cancer.Graphical Abstract
Mathematical Modelling and Experimental Validation of Bifurcation Dynamics of One-Degree-of-Freedom Oscillator with Duffing-Type Stiffness and Rigid Obstacle
Authors: Kudra Grzegorz , Witkowski Krzysztof , Rezaei Mohammad Parsa , Awrejcewicz Jan 
Published: January 2023

Abstract
Purpose
In the work there are presented results of the synthesis and additional validation of previously developed mathematical models of two different mechanical oscillators with 1 degree of freedom and harmonic excitation: (i) with magnetically modified elasticity generating a double symmetrical minimum of potential; (ii) with linear mechanical springs and with a one-sided limiter of motion.

Methods
In the first case, original mathematical models of non-linear magnetic springs were developed, allowing for effective and fast numerical simulations of the bifurcation dynamics of a real mechanical oscillator with Duffing type stiffness. In the second system, various models of impact were proposed and tested: continuous models based on the generalized Hunt–Crossley model and original discontinuous versions of this model based on the restitution coefficient and with a finite duration of the collision. In the frame of the present work, a system consisting of magnetic springs used in the first system and obstacles from the second oscillator was built and investigated. The system was built as a new configuration of a special universal stand used in the earlier studies mentioned here.

Results and Conclusion
In the current study, the parameters of the models identified in previous studies on two different systems were used, the synthesis of which is the current work. A very good agreement was obtained between numerical simulations and experimental data, thus demonstrating the correctness and effectiveness of the adopted mathematical models.
Protective effect of lactoferrin administration against brain tissue damage in diabetic rats
Authors: Al-Sharif Ifat A. 
Published: January 2023

AbstractBovine lactoferrin (bLf), a glycoprotein with iron, Several of Lf's functions intervene through various cell receptors. Its antibacterial, antiparasitic, anti-inflammatory, and antioxidant effects Additionally, it has been found that Lf has immunomodulating. We looked into the protective effects of Lf on various brain tissue indicators and histopathological examination of streptozotocin (STZ) induced diabetic rats. This research aimed to check the potential protective effect of lactoferrin verses brain lesion in STZ induced diabetic rat. The rats were split into five groups: Control (C), Diabetic rat (T2D), T2D + Insulin, T2D + Lactoferrin, and T2D + Insulin + Lactoferrin. Diabetes was created in rat groups by administration STZ (60 mg/kg body weight), then rat was sacrificed. The tissues of the Brain and serum had been chosen to analyze biochemical brain tissue indicators, Serum Neuron-Specific Enolase (SNE), Serum Brain-Derived Neurotrophic Factor (BDNF), and Tissue Necrosis Factor-Alpha (TNF-Alpha). Also, H&E staining was utilized to measure the histological changes of the brain and Comet assay of brain tissue samples for detection of DNA damage. In T2D rat, Lactoferrin corrected aberrant serum levels of SNE, BDNF and TNF-Alpha, in addition, Lactoferrin improves brain pathological changes might be through hypoglycemic, and/or anti-inflammatory actions and reduced DNA damage as compared to diabetic untreated rats. It could be concluded that oral administration of lactoferrin to diabetic rats alone or in combination with insulin treatment for six weeks was found to attenuate the harmful effects of diabetes on brain biomarkers as well as the pathological lesions that occur in the brain tissues of diabetic rats.
Theorising Gambling Self-Exclusion Agreements: The Inadequacy of Procedural Autonomy
Authors: Long Bernard 
Published: January 2023

AbstractGambling self-exclusion agreements enable a person to have themselves prevented from gambling for some future period. In light of evidence of their effectiveness in helping problem gamblers manage their addiction, these agreements enjoy growing popularity. In particular, several jurisdictions now oblige gambling operators to offer self-exclusion to their clientele. If self-exclusion has a unique value that is distinct from paternalistic measures, such as forced exclusion, it is surely because it prizes the gambler’s autonomy. In this article, however, I will argue that self-exclusion’s theoretical basis cannot, in fact, be found in a procedural theory of autonomy that only regards agents’ own values and decisions. Rather, I will contend that if agents may bind their future selves in only some ways—for example, by preventing themselves from gambling but not preventing themselves from self-excluding or selling themselves into slavery—it can only be because of a normative, substantive claim.