bluuebunny/crossref_metadata_2025_split huggingface dataset:
How honey bees make fast and accurate decisions
Authors: MaBouDi HaDi , Marshall James A. R. , Dearden Neville , Barron Andrew B. 
Published: January 2023

AbstractHoney bee ecology demands they make both rapid and accurate assessments of which flowers are most likely to offer them nectar or pollen. To understand the mechanisms of honey bee decision-making we examined their speed and accuracy of both flower acceptance and rejection decisions. We used a controlled flight arena that varied both the likelihood of a stimulus offering reward and punishment and the quality of evidence for stimuli. We found that the sophistication of honey bee decision-making rivalled that reported for primates. Their decisions were sensitive to both the quality and reliability of evidence. Acceptance responses had higher accuracy than rejection responses and were more sensitive to changes in available evidence and reward likelihood. Fast acceptances were more likely to be correct than slower acceptances; a phenomenon also seen in primates and indicative that the evidence threshold for a decision changes dynamically with sampling time. To investigate the minimally sufficient circuitry required for these decision-making capacities, we developed a novel model of decision-making. Our model can be mapped to known pathways in the insect brain and is neurobiologically plausible. Our model proposes a system for robust autonomous decision-making with potential application in robotics.
ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytes
Authors: Hu Xu , Zhu Qingyu , Lou Tianjie , Hu Qianqian , Li Huashun , Niu Xiaojie , He Li , Huang Hao , Xu Yijia , Qiu Mengsheng , Shen Ying , Jia Jie-Min , Tao Yanmei 
Published: January 2023

AbstractWhite matter abnormalities are an emerging feature of schizophrenia, yet the underlying pathophysiological mechanisms are largely unknown. Disruption of ErbB signaling that is essential for peripheral myelination has been genetically associated with schizophrenia and white matter lesions in schizophrenic patients. However, the roles of ErbB signaling in oligodendrocytes remain elusive. Here, we used a pan-ErbB inhibition strategy and demonstrated the synergistic functions of endogenous ErbB receptors in oligodendrocytes. Through analyses of the cellular, histological, biochemical, behavioral, and electrophysiological differences in mice with manipulation of ErbB activities in oligodendrocytes at different differentiation stages, we found that ErbB signaling regulates myelination and aerobic glycolysis in oligodendrocytes, and both functions are required for working memory. ErbB inhibition in oligodendrocytes at early differentiation stages induces hypomyelination by suppressing the differentiation of newly-formed oligodendrocytes. In contrast, ErbB inhibition in mature oligodendrocytes alters neither myelination nor oligodendrocyte numbers, but accelerates axonal conduction decline under energy stress. Mechanistically, mature oligodendrocytes with ErbB inhibition reduce the expression of lactate dehydrogenase A, failing to provide lactate to electrically active axons. Supplementation of L-lactate restores axonal conduction and working memory capacity that are suppressed by ErbB inhibition in mature oligodendrocytes. These findings reveal the indispensable roles of ErbB signaling in white matter integrity and function, and provide insights into the multifaceted contributions of white matter abnormalities to cognitive impairment.
Effect of Nivolumab therapy on Metastatic Lung Cancer in Human Microbiome
Authors: Kubba Rohan , Evans Robert J. , Nguyen Sonha , Pai Ramadas , Borneman James 
Published: January 2023

AbstractNivolumab, a type of immunotherapy, has enhanced the 5-year survival of patients with renal cell cancer, melanoma, and lung cancer which is now mechanistically understood. However, relatively sparse information assesses its relationship with shaping the gut microbiome. We aimed to assess the degree to which nivolumab treatment contributes to alterations in the species composition of the colon in lung cancer patients undergoing nivolumab treatment. Our pilot study utilized stool samples of five lung cancer patients at Inland Hematology Oncology (IHO) before administration of nivolumab and three months after initiation of treatment. 16S and ITS rRNA sequence analysis were used to assess alterations in species abundance and richness of the colon. After sequencing, statistical analysis, specifically a paired t-test, was performed to assess if any significant differences in any microbial species were observed before and after immunotherapy treatment. Although different proportions of microorganisms existed at baseline prior to treatment for each patient, a significant reduction in theMegasphaera elsdeniipopulation was observed (p=.0488; n=4), when comparing before and after treatment. Our findings differ from that of Huang et. al (2022), who has recently posited that a positive association exists betweenMegasphaera elsdeniiand the survival of patients with pancreatic ductal adenocarcinomas. Our conclusions suggest that different cancers may elicit differential effects onMegasphaera elsdeniiin the gut microbiome.ImportanceNivolumab is a relatively new form of cancer therapy called immunotherapy, which enables the body to use its own immune system to effectively fight cancer. Due to advances in microbial sequencing in 16S rRNA, this project explores differences in the abundance of microbial communities before and three months of treatment in patients who have advanced on chemotherapy. Our findings suggest that reduction ofMegasphaera elsdenii, a metabolically active bacterium, is associated with positive outcomes, which differs from findings from other literature. Our project advocates for a more robust profiling of the microbiome during lung cancer treatment, and immunotherapy, in particular, to establish a more substantive profile of the changing gut in the midst of treatment.
Bioinformatics Approaches to Determine the Effect of SARS-CoV-2 Infection on Patients with Intrahepatic Cholangiocarcinoma
Authors: Zhou Xinyi , Huang Tengda , Pan Hongyuan , Lan Jiang , Wu Tian , Du Ao , Song Yujia , Lv Yue , Yuan Kefei 
Published: January 2023

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), has infected millions of individuals throughout the world, which poses a serious threat to human health. COVID-19 is a systemic disease that affects tissues and organs, including the lung and liver. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common liver cancer, and cancer patients are particularly at high risk of SARS-CoV-2 infection. The relationship between HCC and COVID-19 has been reported in previous studies, but ICC has been rare. With the methods of systems biology and bioinformatics, this study explored the link between COVID-19 and ICC. Transcriptional profiling of COVID-19 and ICC were obtained from the GEO database. A total of 70 common differentially expressed gene (DEGs) of both diseases were identified to investigate shared pathways. Then top-ranked 10 key DEGs (SCD, ACSL5, ACAT2, HSD17B4, ALDOA, ACSS1, ACADSB, CYP51A1, PSAT1, and HKDC1) were identified as hub genes by protein-protein interaction (PPI) network analysis. In addition, transcriptional regulatory networks regulating hub genes were revealed by hub Gene-transcription factor (TF) interaction analysis and hub gene-microRNA (miRNAs) interaction analysis. This study is expected to provide new references for future research and treatment of COVID-19 and ICC.
The greenwashing effects on corporate reputation and brand hate, through environmental performance and green perceived risk
Authors: Santos Célia , Coelho Arnaldo , Marques Alzira 
Published: January 2023

PurposeWhen a company practices greenwashing, it violates consumers' expectations by deliberately deceiving them about their environmental practices or the benefits of their products/services. This study investigated the effects of greenwashing on corporate reputation and brand hate. Furthermore, this study explored the mediating effects of perceived environmental performance and green perceived risk.Design/methodology/approachA survey design using cross-sectional primary data from 420 Portuguese consumers who identified and recognized brands engaged in greenwashing was employed. The proposed hypotheses were tested using structural equation modeling techniques.FindingsThis study's findings show that consumer perceptions of greenwashing may damage brands. The results show that greenwashing has a negative effect on corporate reputation through perceived environmental performance and green perceived risk. Additionally, greenwashing has a positive direct effect on brand hate and a negative effect on green perceived risk. Therefore, reducing greenwashing practices can improve consumers' perceptions of corporate environmental performance, buffer green perceived risk, and ultimately enhance corporate reputation. This can lead to positive relationships with customers.Originality/valueBased on signaling and expectancy violation theories, this study develops a new framework highlighting the detrimental effects of greenwashing on brands. The combination of these theories provides the right framework to understand how greenwashing may lead to extreme feelings like brand hate and negative perceptions of corporate reputation, thus advancing the current research that lacks studies on the association between these constructs.
Does TMT internationalization promote corporate digital transformation? A study based on the cognitive process mechanism
Authors: Chen Yujiao , Li Rui , Song Tiebo 
Published: January 2023

PurposeCorporate digital transformation (DT) and top management team (TMT) internationalization seem to be concomitant phenomena in recent years, the former is a major change and a thorough transformation requiring continuously new technologies and ideas. Excitingly, the latter shows a relatively broad vision, a large risk appetite and interest in new things. Does TMT internationalization promote DT? This question is essential for DT. Given that, this article will aim to discuss and examine whether and how TMT internationalization affects corporate DT.Design/methodology/approachThis article takes China's A-share listed manufacturing companies from 2011 to 2019 as a sample. The quantitative text analysis method is used to measure attention related to digitalization. This paper discusses: (1) The decision-making logic and cognitive process mechanism of “TMT internationalization–attention related to digitalization–corporate DT”. (2) The moderating effect of shared corporate mission of the TMT on the cognitive process of decision-making, that is, the social process of transforming individual cognition into team cognition, and the social process of transforming team cognition into corporate decision-making.FindingsTMT internationalization promotes DT. As an external manifestation of team cognition, attention plays a positive role as an intermediary mechanism. Specifically, executives with overseas experience have higher urgency assessment and manageable assessment, thus affecting their attention to digitalization positively, thereby promoting DT. This article does not demonstrate the moderating effect of shared corporate mission on the cognitive process, but it promotes DT directly, and only plays a role in the precognitive stage.Originality/valueThis article is the first one to study the relationship between TMT internationalization and corporate DT, which has practical guiding significance for DT and the “going out” strategies of the TMT. Also, the combination of upper echelons theory and cognitive theory opens up the black box of the strategic process. Lastly, this research explores the formation process of team cognition, which is always neglected by previous studies of the TMT demographic characteristics.
A global perspective on the impact of COVID-19 on peer-to-peer accommodation: human mobility, case number and lockdown policies
Authors: Cheng Mingming , Hu Maggie , Lee Adrian 
Published: January 2023

Purpose
Taking a global perspective, this paper aims to examine the impact of COVID-19 on Airbnb booking activities through three critical perspectives – the initial Wuhan lockdown, local COVID-19 cases and local lockdowns.

Design/methodology/approach
Using Airbnb reviews and cancellations as proxies for Airbnb bookings on a global scale, econometrics was used to examine the impacts of the initial Wuhan lockdown, local COVID-19 cases and local lockdowns on Airbnb bookings.

Findings
The authors find that local lockdowns result in a 57.8% fall in global booking activities. Every doubling of newly infected cases is associated with a 4.16% fall in bookings. The sensitivity of bookings to COVID-19 decreases with geographic distance to Wuhan and increases with government stringency of lockdown policies and human mobility within a market.

Practical implications
The empirical evidence from this research can provide governments with insights into more accurate assessment of the financial loss of Airbnb hosts so that proper support can be offered based on the financial needs because of due to sudden lockdown.

Originality/value
This research contributes to new knowledge on peer-to-peer accommodation during a time of crisis and provides much needed global evidence to understand the impacts of COVID-19 on the accommodation industry.
Female genital mutilation (FGM) trauma and mental health support during the UK lockdown: exploring women’s experiences
Authors: Mulongo Peggy , Khan Roxanne , McAndrew Susan , McKeown Michael 
Published: January 2023

Purpose
The purpose of this study is to report findings from interviews with seven African-heritage women attending a female genital mutilation (FGM) Clinic in the north of England, during the COVID-19 lockdown. The Clinic, established several years before the pandemic, provides specialist therapeutic support to women and girls from minority ethnic communities who are affected by harmful “traditional” practices, including FGM. The services provided by the Clinic include early interventions, peer support, community engagement and empowerment around FGM.

Design/methodology/approach
Data was collected during an online focus group discussion with seven women who had received counselling for FGM, to gain insight into their lived experiences of therapeutic support during the pandemic.

Findings
Using Braun and Clarke (2006) six-step thematic analysis, four superordinate themes derived from the data: consistency and continuity; safety in shared experience and creativity; feeling heard, feeling stronger; and altruism and desire for change.

Research limitations/implications
It is important to recognise some limitations within this study. It is based on one focus group discussion that involved seven participants, who had experienced FGM, were living in a targeted area and whose mental health had been further compromised by the COVID-19 pandemic.

Practical implications
The findings of this study indicate that it is essential to consider participants’ experiences of receiving therapeutic support during the COVID-19 pandemic. It was observed that emotional stressors linked with participants’ experiences of FGM may be exacerbated by those related to COVID-19.

Social implications
There is a need to conduct similar research, perhaps on an individual basis, that would reach a wider sample of women from ethnic minority populations who are survivors of FGM, including those from FGM practicing communities who have been hospitalised through their deteriorating mental health. This would add to the small but growing body of evidence, to provide a better understanding of the experiences of their mental health needs during the COVID-19 pandemic and perhaps better identify effective therapeutic interventions.

Originality/value
These themes provide an insight into these women’s experiences of the trauma associated with FGM and receiving mental health support during the pandemic.
Examining stress regulation impacts from integrating mindfulness and self-compassion interventions into doctoral-level leadership courses
Authors: Hariharan Yamini , Meiers Christopher , Robert Catherine , Bresciani Ludvik Marilee 
Published: January 2023

PurposeThe aim of this paper is to explore mindfulness and self-compassion teachings and practices embedded in a leadership course and their outcome on stress regulation of doctoral-level students.Design/methodology/approachEight valid and reliable pre-and post-assessment inventories were administered prior to the first week of class and following the completion of the doctoral-level class. The test scores were measured for improvement and for differences between various demographic groups.FindingsThe results suggest significant improvement on almost every mindfulness subscale with approximately 5–22% of the variance in subscale scores attributed to participation. Doctoral students over 40 indicated more score improvement than students under 40, and doctoral students of color indicated more significant score increases than White students.Research limitations/implicationsThe research involves doctoral-level students which limits generalizability to other levels of education. Based on the findings, scaling analysis should be conducted on other types of students for generalization purposes.Practical implicationsInstitutions looking to incorporate wellness practices into curriculum can embed these types of practices into their course design.Social implicationsFaculty can become more intentional in how they engage students in mindful compassion skills within their academic programs.Originality/valueThe paper adds a quantitative study into the literature surrounding efficacy of wellness practices in structured curriculum. Institutions looking to provide more resources to students to improve their wellness may find the model useful on their campuses, particularly for students over 40 and students of color.
Selective and differential feeding on marine prokaryotes by mucous mesh feeders
Authors: Thompson Anne W. , Sweeney Carey P. , Sutherland Kelly R. 
Published: January 2023

AbstractMicrobial mortality impacts the structure of food webs, carbon flow, and the interactions that create dynamic patterns of abundance across gradients in space and time in diverse ecosystems. In the oceans, estimates of microbial mortality by viruses, protists, and small zooplankton do not account fully for observations of loss, suggesting the existence of underappreciated mortality sources. We examined how ubiquitous mucous mesh feeders (i.e. gelatinous zooplankton) could contribute to microbial mortality in the open ocean. We coupled capture of live animals by blue‐water diving to sequence‐based approaches to measure the enrichment and selectivity of feeding by two coexisting mucous grazer taxa (pteropods and salps) on numerically dominant marine prokaryotes. We show that mucous mesh grazers consume a variety of marine prokaryotes and select between coexisting lineages and similar cell sizes. We show that Prochlorococcus may evade filtration more than other cells and that planktonic archaea are consumed by macrozooplanktonic grazers. Discovery of these feeding relationships identifies a new source of mortality for Earth's dominant marine microbes and alters our understanding of how top‐down processes shape microbial community and function.
The development of a tumor‐associated autoantibodies panel to predict clinical outcomes for immune checkpoint inhibitor‐based treatment in patients with advanced non‐small‐cell lung cancer
Authors: Zhao Jing , Wu Yang , Yue Yuan , Chen Minjiang , Xu Yan , Liu Xiangning , Liu Xiaoyan , Gao Xiaoxing , Wang Hanping , Si Xiaoyan , Zhong Wei , Zhang Xiaotong , Zhang Li , Wang Mengzhao 
Published: January 2023

AbstractBackgroundImmune checkpoint inhibitors (ICIs) have become one important therapeutic strategy for advanced non‐small‐cell lung cancer (NSCLC). It remains imperative to identify reliable and convenient biomarkers to predict both the efficacy and toxicity of immunotherapy, and tumor‐associated autoantibodies (TAAbs) are recognized as one of the promising candidates for this.Patients and MethodsThis study enrolled 97 advanced NSCLC patients with ICI‐based immunotherapy treatment, who were divided into a training cohort (n = 48) and a validation cohort (n = 49), and measured for the serum level of 35 TAAbs. According to the statistical association between the serum positivity and clinical outcome of each TAAb in the training cohort, a TAAb panel was developed to predict the progression‐free survival (PFS), and further examined in the validation cohort and in different subgroups. Similarly, another TAAb panel was derived to predict the occurrence of immune‐related adverse events (irAEs).ResultsIn the training cohort, a 7‐TAAb panel composed of p53, CAGE, MAGEA4, GAGE7, UTP14A, IMP2, and PSMC1 TAAbs was derived to predict PFS (median PFS [mPFS] 9.9 vs. 4.3 months, p = 0.043). The statistical association between the panel positivity and longer PFS was confirmed in the validation cohort (mPFS 11.1 vs. 4.8 months, p = 0.015) and in different subgroups of patients. Moreover, another 4‐TAAb panel of BRCA2, MAGEA4, ZNF768, and PARP TAAbs was developed to predict the occurrence of irAEs, showing higher risk in panel‐positive patients (71.43% vs. 28.91%, p = 0.0046).ConclusionsCollectively, our study developed and validated two TAAb panels as valuable prognostic biomarkers for immunotherapy.
Efficacy and safety of antiangiogenic agents or chemotherapy plus EGFR‐TKIs in advanced non‐small cell lung cancer: A systematic review and network meta‐analysis
Authors: Dai Jiali , Liu Xinyin , Li Jun , Qu Tianyu , Cui Yanan , Jin Shidai , Zhang Erbao , Guo Renhua 
Published: January 2023

AbstractBackgroundThe combination of antiangiogenic agents with epidermal growth factor receptor inhibitors (EGFR‐TKIs) and chemotherapy with EGFR‐TKIs are the most common combination treatment options in epidermal growth factor receptor (EGFR) positive non‐small cell lung cancer (NSCLC). This network meta‐analysis was performed to evaluate the differences between them.MethodsWe searched the PubMed, EMBASE and the Cochrane Controlled Trials Register up to August 2022. The primary outcomes were progression‐free survival (PFS) and objective response rate (ORR). The secondary endpoints were overall survival (OS), disease control rate (DCR) and adverse events (AEs). The data of hazard ratio (HR) or risk ratio (RR) with their corresponding 95% confidence intervals (CIs) were extracted in the studies. A network meta‐analysis (NMA) was used to indirectly compare the efficacy and safety of antiangiogenic agents plus EGFR‐TKIs and chemotherapy plus EGFR‐TKIs.ResultsPooled data of included studies were demonstrated that chemotherapy plus EGFR‐TKIs had a benefit in ORR compared to antiangiogenic agents plus EGFR‐TKIs in patients with EGFR mutated NSCLC (RR = 1.1, 95% CI: 1.0–1.2). However, there were no significant differences in PFS, OS and DCR between in the two group (PFS: HR = 1.0, 95% CI: 0.74–1.6; OS: HR = 0.78, 95% CI: 0.45–1.5; DCR: RR = 1.0, 95% CI: 0.94–1.1). The common treatment‐related AEs in the two groups were relatively manageable.ConclusionBased on the efficacy and safety, the combination of chemotherapy with EGFR‐TKIs is considered the best combination treatment options in advanced NSCLC with EGFR mutation.