bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication
Authors: Goodwin Guy M. , Croal Megan , Feifel David , Kelly John R. , Marwood Lindsey , Mistry Sunil , O’Keane Veronica , Peck Stephanie Knatz , Simmons Hollie , Sisa Claudia , Stansfield Susan C. , Tsai Joyce , Williams Sam , Malievskaia Ekaterina 
Published: July 2023

AbstractPsilocybin is being investigated as a treatment in adults with treatment-resistant depression (TRD). Withdrawal from serotonergic antidepressant drugs is a common prerequisite for taking part in trials of psilocybin due to the possibility of ongoing antidepressant drugs altering the psychedelic effect. This phase II, exploratory, international, fixed-dose, open-label study explored the safety, tolerability, and efficacy of a synthetic form of psilocybin (investigational drug COMP360) adjunct to a selective serotonin reuptake inhibitor in participants with TRD. Participants received a single 25 mg dose of psilocybin alongside psychological support and were followed-up for 3 weeks. The primary efficacy end point was change in the Montgomery-Åsberg Depression Rating Scale (MADRS) total score from Baseline at Week 3. Secondary end points were safety, including treatment-emergent adverse events (TEAEs), the proportion of responders and remitters at Week 3, and the change from Baseline to Week 3 in Clinical Global Impression–Severity (CGI-S) score. Nineteen participants were dosed and the mean Baseline MADRS total score was 31.7 (SD = 5.77). Twelve (63.2%) participants had a TEAE, most of which were mild and resolved on the day of onset. There were no serious TEAEs or indication of increased suicidal ideation or behavior. At Week 3, mean change from Baseline in MADRS total score was −14.9 (95% CI, −20.7 to −9.2), and −1.3 (SD = 1.29) in the CGI-S. Both response and remission were evident in 8 (42.1%) participants. Larger, comparator-controlled trials are necessary to understand if this paradigm can optimize treatment-outcome where antidepressant drug withdrawal would be problematic.
Trichlorobacter ammonificans, a dedicated acetate-dependent ammonifier with a novel module for dissimilatory nitrate reduction to ammonia
Authors: Sorokin Dimitry Y , Tikhonova Tamara V , Koch Hanna , van den Berg Eveline M , Hinderks Renske S , Pabst Martin , Dergousova Natalia I , Soloveva Anastasia Y , Kuenen Gijs J , Popov Vladimir O , van Loosdrecht Mark C M , Lücker Sebastian 
Published: July 2023

Abstract
Dissimilatory nitrate reduction to ammonia (DNRA) is a common biochemical process in the nitrogen cycle in natural and man-made habitats, but its significance in wastewater treatment plants is not well understood. Several ammonifying Trichlorobacter strains (former Geobacter) were previously enriched from activated sludge in nitrate-limited chemostats with acetate as electron (e) donor, demonstrating their presence in these systems. Here, we isolated and characterized the new species Trichlorobacter ammonificans strain G1 using a combination of low redox potential and copper-depleted conditions. This allowed purification of this DNRA organism from competing denitrifiers. T. ammonificans is an extremely specialized ammonifier, actively growing only with acetate as e-donor and carbon source and nitrate as e-acceptor, but H2 can be used as an additional e-donor. The genome of G1 does not encode the classical ammonifying modules NrfAH/NrfABCD. Instead, we identified a locus encoding a periplasmic nitrate reductase immediately followed by an octaheme cytochrome c that is conserved in many Geobacteraceae species. We purified this octaheme cytochrome c protein (TaNiR), which is a highly active dissimilatory ammonifying nitrite reductase loosely associated with the cytoplasmic membrane. It presumably interacts with two ferredoxin subunits (NapGH) that donate electrons from the menaquinol pool to the periplasmic nitrate reductase (NapAB) and TaNiR. Thus, the Nap-TaNiR complex represents a novel type of highly functional DNRA module. Our results indicate that DNRA catalyzed by octaheme nitrite reductases is a metabolic feature of many Geobacteraceae, representing important community members in various anaerobic systems, such as rice paddy soil and wastewater treatment facilities.
First report on the presence of huanglongbing vectors (Diaphorina citri and Trioza erytreae) in Ghana
Authors: Aidoo Owusu F. , Ablormeti Fred K. , Ninsin Kodwo D. , Antwi-Agyakwa Akua K. , Osei-Owusu Jonathan , Heve William K. , Dofuor Aboagye K. , Soto Yovanna L. , Edusei George , Osabutey Angelina F. , Sossah Frederick L. , Aryee Clement O. , Alabi Olufemi J. , Sétamou Mamoudou 
Published: July 2023

AbstractAs significant threats to global citrus production, Diaphorina citri (Kuwayama; Hemiptera: Psyllidae) and Trioza erytreae (Del Guercio; Hemiptera: Triozidae) have caused considerable losses to citrus trees globally. Diaphorina citri vectors “Candidatus Liberibacter asiaticus” and “Ca. L. americanus”, whereas T. erytreae transmits “Ca. L. africanus” and “Ca. L. asiaticus”, the pathogens responsible for citrus greening disease or Huanglongbing (HLB). Though HLB is a destructive disease of citrus wherever it occurs, information on the occurrence and geographical distribution of its vectors in Africa is limited. In recent surveys to determine if HLB vectors are present in Ghana, we observed eggs, nymphs, and adults of insects suspected to be D. citri and T. erytreae. Using morphological traits and DNA analyses, the identity of the suspected insects was confirmed to be D. citri and T. erytreae. Individuals of D. citri and T. erytreae were examined using qPCR for CLaf, CLam, and CLas, but none of them tested positive for any of the Liberibacter species. Herein we report, for the first time, the presence of D. citri and T. erytreae in Ghana (West Africa). We discuss the implications of this new threat to the citrus industry to formulate appropriate management strategies.
Avalanche-size distribution of Cayley tree
Authors: Patron Amikam 
Published: July 2023

AbstractAttacks on networks is a very important issue in developing strategies of eradicating spreads of malicious phenomena in networks, such as epidemics and fake information. This field of research is referred to as networks immunization. The traditional approach to evaluating the effectiveness of attacks on networks focuses on measuring macro parameters related to the entire attack, such as the critical probability of a percolation occurrence in the network $$p_c$$

p
c

and the relative size of the largest component in the network, known as the giant component, but not considering the attack on a micro perspective, which is the analysis of node removals, during an attack, themselves, their characteristics and results. In this paper we present and apply the last method of focusing on the micro scale of an attack. Based on the theory of percolation in networks, we analyze the phenomenon of an avalanche which results due to a single node removal from a network. An avalanche is a state in which a removal of a single node from the giant component of a network leads to the disconnection of additional nodes. This process significantly contributes to the fragmentation (immunization) of the network, comparing to the impact of the initial node removal alone. Specifically, we focus on the size parameter of an avalanche, which is the number of nodes that are disconnected from the giant component due to a single node removal. Relating to a random attack on a network of the type of Cayley tree, we derive analytically the distribution of the sizes of avalanches that occur during the entire attack on it, until the network is dismantled (immunized) and the attack is terminated.
Stability of the emulsion during the injection of anionic and cationic surfactants in the presence of various salts
Authors: Garmsiri Hamid , Jahani Shahriar , Kazemzadeh Yousef , Sharifi Mohammad , Riazi Masoud , Azin Reza 
Published: July 2023

AbstractSmart water injection is one of the engineering techniques to enhance oil recovery (EOR) from carbonate and sandstone reservoirs that have been widely used in recent decades. Wettability alteration and IFT are among the essential and influential mechanisms that can be mentioned to achieve EOR. One of the critical issues in the field of EOR is the effect of reservoir ions on the formation and stability of the emulsion. Investigating the role and performance of these ions during EOR processes is of significant importance. These processes are based on smart water injection and natural production. In this research, stability was investigated and formed during the injection of different concentrations of anionic and cationic surfactants, respectively alpha olefin sulfonate (AOS) and cetrimonium bromide (CTAB), into a water–oil emulsion with a volume ratio of 30–70. Considering the droplet diameter distribution and the flow speed of separation by centrifugation, the optimal concentration level has been investigated in both surfactants. Based on the results, the highest stability and emulsion formation occurred in the presence of AOS surfactant. Then different concentrations of CaCl2, MgCl2, and NaCl salts were added in optimal concentrations of both surfactants. The formation and stability of the emulsion was checked by examining the distribution of the droplet diameter and the separation flow rate. AOS anionic surfactant had the most stability in the presence of MgCl2 salt, and better performance in stability of the emulsion was obtained. The maximum number of droplet diameters in the optimal concentration for AOS and CTAB surfactant systems is 1010 and 880, respectively, and for binary systems of AOS surfactant and MgCl2, CaCl2 and NaCl salts, it is 2200, 1120 and 1110, respectively. Furthermore, for the CTAB binary system in the presence of MgCl2, CaCl2, and NaCl salts, it is 1200, 1110, and 1100, respectively. The stability of the emulsion of salts in the presence of both AOS and CTAB surfactants was MgCl2 > CaCl2 > NaCl.
“You’re a woman now”
Authors: Metreveli Anna 
Published: July 2023

Abstract
This paper analyses menarche episodes from TV series using the discourse-historical approach to compare how
menarche has been depicted on TV during different decades and takes a closer look into inter-generational experience of menarche.
The analysis focuses on membership categorization analysis of the scenes and dialogues involving menarche. After analyzing several
decades of menstrual discourse, it is possible to conclude that TV discourse has changed from depicting menarche as a shameful
taboo to a powerful visual storyline statement. However, the menarche scenarios did not change dramatically and continue to rely
heavily on a mother-daughter bonding plot and highlight childbearing as the main and sometimes the only positive aspect of
menstruation. The continuous use of menstruational euphemisms is still predominating the TV discourse.
Do “Chinese gays” come out?
Authors: Freestone Phil 
Published: July 2023

AbstractThis paper draws on linguistic-ethnographic fieldwork in Chengdu, China to consider the utility of broad labels such asChinese, Westernandgayin accounting for the performance of sexual and cultural identity. I problematise work which takes such notions to be stable and self-evidently referential, arguing instead that identity is much more fluid, emergent and discourse-dependent than conventional understandings tend to imply. I focus on visibility of queer sexual identity partly because it is an especially accessible example of the role of language in identity performance, being most often achieved through verbal interaction. More broadly, however, this focus emerged through my ethnographically informed, discursive-sociocultural approach to my life and research in mainland China during the period 2008–2019. Specifically, I use spoken data from the interviews which formed part of this process to argue that social practice within related ethnic and/or social groups is best understood in terms of the situated use of sociolinguistic tools and the entailed negotiation of pertinent ideological systems. From this perspective, the ostensibly insurmountable ideological pressures that “Chinese gays” are typically seen to face, and which tend to be attributed to a taken-for-granted and monolithic “Chinese culture”, are better interpreted with reference to the complex relationship between language, culture and identity. Thus, I do not assume the right to make broad claims about whatChinese gaysdo, or to state that they are categorically different from their presumed homogenousWesterncounterparts. Instead, I discuss what certain individuals say in certain conversations, noting how their performance of identity is often highly individualised, being shaped according to the interactants present and the interactional aims relevant to specific moments of communication.
Anti-infective activities of long-chain fatty acids against foodborne pathogens
Authors: Borreby Caroline , Lillebæk Eva Maria Sternkopf , Kallipolitis Birgitte H 
Published: July 2023

Abstract
Free fatty acids (FFAs) have long been acknowledged for their antimicrobial activity. More recently, long-chain FFAs (&gt;12 carbon atoms) are receiving increased attention for their potent antivirulence activity against pathogenic bacteria. In the gastrointestinal tract, foodborne pathogens encounter a variety of long-chain FFAs derived from the diet, metabolic activities of the gut microbiota, or the host. This review highlights the role of long-chain FFAs as signaling molecules acting to inhibit the infectious potential of important foodborne pathogens, including Salmonella and Listeria monocytogenes. Various long-chain FFAs interact with sensory proteins and transcriptional regulators controlling the expression of infection-relevant genes. Consequently, long-chain FFAs may act to disarm bacterial pathogens of their virulence factors. Understanding how foodborne pathogens sense and respond to long-chain FFAs may enable the design of new anti-infective approaches.
Comparing rates of adverse events detected in incident reporting and the Global Trigger Tool: a systematic review
Authors: Hibbert Peter D , Molloy Charlotte J , Schultz Timothy J , Carson-Stevens Andrew , Braithwaite Jeffrey 
Published: July 2023

Abstract
Many hospitals continue to use incident reporting systems (IRSs) as their primary patient safety data source. The information IRSs collect on the frequency of harm to patients [adverse events (AEs)] is generally of poor quality, and some incident types (e.g. diagnostic errors) are under-reported. Other methods of collecting patient safety information using medical record review, such as the Global Trigger Tool (GTT), have been developed. The aim of this study was to undertake a systematic review to empirically quantify the gap between the percentage of AEs detected using the GTT to those that are also detected via IRSs. The review was conducted in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies published in English, which collected AE data using the GTT and IRSs, were included. In total, 14 studies met the inclusion criteria. All studies were undertaken in hospitals and were published between 2006 and 2022. The studies were conducted in six countries, mainly in the USA (nine studies). Studies reviewed 22 589 medical records using the GTT across 107 institutions finding 7166 AEs. The percentage of AEs detected using the GTT that were also detected in corresponding IRSs ranged from 0% to 37.4% with an average of 7.0% (SD 9.1; median 3.9 and IQR 5.2). Twelve of the fourteen studies found &lt;10% of the AEs detected using the GTT were also found in corresponding IRSs. The &gt;10-fold gap between the detection rates of the GTT and IRSs is strong evidence that the rate of AEs collected in IRSs in hospitals should not be used to measure or as a proxy for the level of safety of a hospital. IRSs should be recognized for their strengths which are to detect rare, serious, and new incident types and to enable analysis of contributing and contextual factors to develop preventive and corrective strategies. Health systems should use multiple patient safety data sources to prioritize interventions and promote a cycle of action and improvement based on data rather than merely just collecting and analysing information.
Relationship Between Sexually Transmitted Infections and Social Determinants of Health in Durham County, North Carolina, United States
Authors: Jenks Jeffrey D , Nipp Emma , Tadikonda Ananya , Karumuri Nishitha , Morales-Lagunes Kristie , Carrico Savannah , Mortiboy Marissa , Zitta John-Paul 
Published: July 2023

Abstract

Background
Sexually transmitted infections (STIs) are increasing in the United States, and certain populations are more at risk than others. One explanation for this is inequities in underlying social determinants of health (SDOH).

Methods
We analyzed chlamydia, gonorrhea, and syphilis cases in Durham County, North Carolina, from 01/01/2020 to 12/31/2020 by select SDOH at the census tract level. We included 48 variables of interest, including variables related to income, education, transportation, and health insurance. For each variable, we modeled STI incidence at the census tract level using Poisson regression. Wald's chi-square was used to determine which variables were significantly associated with STI incidence.

Results
Of 24 variables that were statistically associated with STI incidence at the census tract level, 9 were negatively associated and 15 positively associated with STI incidence. Having employer health insurance was most strongly associated with lower-than-expected STI incidence, and having Medicaid insurance, no health insurance, using public transportation, and income below the poverty level were most strongly associated with higher-than-expected STI incidence. Lastly, STI incidence was not associated with race or ethnicity overall across Durham County, except in historically marginalized areas, where we found higher-than-expected STI incidence.

Conclusions
We found that lacking health insurance, having Medicaid insurance, using public transportation, and income below the poverty level were most strongly associated with higher-than-expected STI incidence. Strategies to combat increasing STIs may include improving access to health insurance, reducing barriers to cost-effective and timely transportation to medical appointments, and raising wages to bring individuals out of poverty.
Successful Treatment of Cutibacterium acnes Prosthetic Joint Infection With Single-Stage Exchange and Oral Antibiotics
Authors: Kohm Kevin , Seneca Kathleen , Smith Krystle , Heinemann Danielle , Nahass Ronald G 
Published: July 2023

Abstract
Interest has grown in less invasive surgical treatment and early use of oral antibiotics in the treatment of Cutibacterium acnes prosthetic joint infection. We report a series of patients who were successfully treated with single-stage exchange and an all-oral course of rifampin and linezolid.
Pathology and new insights in central nervous system lymphomas
Authors: Lebrun Laetitia , Allard-Demoustiez Sacha , Salmon Isabelle 
Published: July 2023

Purpose of review
Primary central nervous system lymphoma (PCNSL) is a rare central nervous system (CNS) malignancy, which represents a heterogenous group of tumors. Among PCNSL, diffuse large B-cell lymphoma of the CNS (CNS-DLBCL) represents the most common tumor type. Multiomics studies have recently revealed the complex genomic landscape of these rare diseases. These findings lead to a potential new molecular and epigenetic classification.

Recent findings
Our review is focused on CNS-DLBCL in immunocompetent patients. CNS-DLBCL are derived from self-reactive/polyreactive precursor cells. An early molecular event such as MYD88 mutation leads to escape elimination of precursor cells, which, by a dysregulated GC reaction, acquire auto-/polyreactivity of the B-cell tumoral cells for antigens physiologically expressed in the CNS. Most of CNS-DLBCL tumor cells harbor a non-GCB, ABC-like immunophenotype associated with a late GC (exit) B-cells genotype by gene expression profiling. Various mechanisms of genetic alterations are involved in the pathogenesis of PCNSL, including point mutations [nonsomatic hypermutation (SHM), aberrant SHM (aSHM)], SHM/aSHM, chromosome copy gains or losses, and DNA hypermethylation. Constitutive NFκB activation plays a key role in lymphoma cell proliferation and survival by dysregulation of toll-like receptor (mutations of CARD11 and MYD88), BCR (CD79B), JAK-STAT, and NFκB signaling pathways.

Summary
Multiomics approaches have succeeded to substantially improve the understanding of the pathogenesis, as well as the molecular and epigenetic events in PCNSL. Challenges remain due to the obvious heterogeneity of CNS-DLBCL, and improvement is needed for their classification.
Understanding endometriosis from an immunomicroenvironmental perspective
Authors: Fan Dian , Wang Xu , Shi Zhixian , Jiang Yuting , Zheng Bohao , Xu Lian , Zhou Shengtao 
Published: July 2023

Abstract
Endometriosis, a heterogeneous, inflammatory, and estrogen-dependent gynecological disease defined by the presence and growth of endometrial tissues outside the lining of the uterus, affects approximately 5–10% of reproductive-age women, causing chronic pelvic pain and reduced fertility. Although the etiology of endometriosis is still elusive, emerging evidence supports the idea that immune dysregulation can promote the survival and growth of retrograde endometrial debris. Peritoneal macrophages and natural killer (NK) cells exhibit deficient cytotoxicity in the endometriotic microenvironment, leading to inefficient eradication of refluxed endometrial fragments. In addition, the imbalance of T-cell subtypes results in aberrant cytokine production and chronic inflammation, which contribute to endometriosis development. Although it remains uncertain whether immune dysregulation represents an initial cause or merely a secondary enhancer of endometriosis, therapies targeting altered immune pathways exhibit satisfactory effects in preventing disease onset and progression. Here, we summarize the phenotypic and functional alterations of immune cells in the endometriotic microenvironment, focusing on their interactions with microbiota and endocrine and nervous systems, and how these interactions contribute to the etiology and symptomology of endometriosis.