bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreaticoduodenectomy with preoperative total embolization of the hepatic arteries (PD-HAE)—a novel treatment with sacrifice of the hepatic arterial blood supply without the need for arterial reconstruction
Authors: Storkholm JH , Burgdorf SK , Larsen PN , Hansen CP 
Published: August 2023

Abstract

Purpose
Tumors with involvement of common hepatic and gastroduodenal arteries (CHA and GDA) or GDA and the proper hepatic artery (PHA) are traditionally considered nonresectable. We have devised a new procedure that includes pancreaticoduodenectomy with preoperative hepatic artery embolization (PD-HAE) to facilitate an R0 resection of tumors involving the hepatic arteries without vascular anastomoses and complete sacrifice of normal hepatic arterial blood supply.

Methods
To allow resection of the hepatic arteries, preoperative embolization of the PHA was performed to induce an increased collateral arterial blood flow from the periphery of the liver, far from the hepatic hilum 10–14 days prior to the operation. Between May 1, 2017 and December 31, 2019, eight patients with ductal adenocarcinoma were operated with the PD-HAE procedure.

Results
The embolizations were uneventful apart from a transient marginal elevation of alanine aminotransferase in three patients.
All patients had N disease with perineural invasion of tumor cells around the adventitia of the artery and severe perivascular inflammation.
An R0 resection (> 1.0 mm to all resection margins) was obtained in six patients (75%). Mean hospital stay was 12 days. Median survival was 23 months (95% CI: 19.5–26.5 months).
Six patients (75%) are still alive 11 to 36 months after the operation. There was perioperative fatality, and morbidity was comparable to standard pancreaticoduodenectomy.

Conclusion
PD-HAE is a safe procedure and may provide the opportunity for curative resection in otherwise unresectable patients. However, larger studies are needed to evaluate this procedure.
Effects of aurantiamide on a rat model of renovascular arterial hypertension
Authors: Aslan Mutay , Basralı Filiz , Ülker Pınar , Barut Zerrin , Yılmaz Çağatay , Çeker Tuğçe , Özen Nur , Öztüzün Aleyna , Elpek Özlem 
Published: August 2023

AbstractAsperglaucide (ASP) is an aurantiamide, an effective constituent of purslane (Portulaca oleraceaL.), a safe to eat greenery. Effects of ASP on endothelial function, endothelial nitric oxide synthase (eNOS) expression, vascular fluidity, renal and vascular reactive oxygen, and nitrogen species (ROS/RNS) production was examined in the two-kidney one-clip (2 K-1C) rat model of renovascular arterial hypertension. ASP toxicity, dose dependent eNOS gene expression and protein levels were also analyzed in human umbilical vein endothelial cells (HUVEC). The 2 K-1C model of hypertension was created via surgery and mean blood pressure (MBP) was measured by tail-cuff method during four weeks of ASP treatment. Erythrocyte deformability was monitored by rotational ektacytometry, while vascular constrictor and dilator responses were determined in organ baths. eNOS gene expression and protein levels were assessed in thoracic aorta and HUVEC. MBP was significantly decreased in hypertensive rats treated with ASP. Endothelium dependent vascular dilator and constrictor responses were also considerably improved following ASP treatment. There was a notable increase in red blood cell deformability in hypertensive rats treated with ASP as compared to hypertensive rats alone. A significant increase was observed in eNOS gene expression and protein levels in both normotensive and hypertensive rats treated with ASP. Treatment of HUVEC with 3 µM ASP notably increased eNOS mRNA and protein levels. In conclusion, ASP lowered blood pressure, improved endothelium-mediated relaxation, decreased renovascular ROS/RNS production in hypertensive rats. ASP also increased eNOS protein expression in aorta and HUVEC at nontoxic doses. ASP may have future potential as an anti-hypertensive agent.
Priming and eruption of andesite magmas at Taranaki volcano recorded in plagioclase phenocrysts
Authors: Shane Phil , Costa Fidel , Cronin Shane , Stirling Claudine , Reid Malcolm 
Published: August 2023

AbstractPlagioclase phenocrysts in pre-historic andesites provide insight to the dynamics of magma formation and eruption at Taranaki volcano, New Zealand. The phenocryst population has a diversity of relic cores and a total in situ 87Sr/86Sr range of 0.70440–0.70486. Within-sample 87Sr/86Sr variations of 0.00018 to 0.00043 indicate that many phenocrysts are antecrysts and/or xenocrysts, derived from multiple crystal mush bodies. The Sr-isotopic differences in the phenocrysts of consecutive eruptions indicate that different magmas were tapped or formed on a centennial timescale. Most phenocrysts have multiple resorption/calcic regrowth zone(s) with elevated FeO* but invariant MgO zonation profiles. They likely record mafic melt inputs, and subsequent storage at elevated temperature caused re-equilibration of the Mg gradient. However, distinct rim types record different final pre/syn-eruptive magmatic conditions. Those in magmas erupted at 1030–1157 CE, 1290–1399 CE and 1780–1800 CE are characterised by resorption and calcic regrowth with sharp MgO and FeO* gradients. They record the entry of mafic melt into the system a few days or less before eruption based on Mg diffusion chronometry. In contrast, most phenocrysts erupted at 1755 CE, 1655 CE, and a few pre-1 ka events, have texturally uniform rims, compositionally consistent with closed-system crystallisation. This suggests alternating external and internal eruption triggers. Alternatively, the rate of magma reactivation via intrusion may dictate whether there was sufficient time for a mineralogical response to be recorded in part or all of the system. With respect to anticipating future eruptions, the plagioclase phenocrysts suggest multi-stage magma priming but rapid onset of the final trigger.
A benchmark for variably saturated variable-density variable-viscosity flow and solute transport in porous media
Authors: Guevara Morel Carlos R. , Graf Thomas 
Published: August 2023

AbstractIn natural environments, fluid density and viscosity can be affected by spatial and temporal variations of solute concentration, for example, due to saltwater intrusion in coastal aquifers, leachate infiltration from waste disposal sites, and upconing of saline water from deep aquifers. Potentially unstable situations may arise in which a dense fluid overlies a less dense fluid. This situation can produce instabilities manifested by dense plume fingers moving vertically downwards counterbalanced by vertical upward flow of the less dense fluid. The resulting free convection increases solute transport rates over large distances and times relative to constant-density flow. Unstable brine flow is further complicated if the porous medium is variably saturated. The results from a laboratory experiment of variably saturated variable-density flow and solute transport from Simmons et al. (2002) are used as the physical basis to define a new mathematical benchmark. This benchmark aims at realistically reproducing the experimental fingering patterns. Random hydraulic conductivity fields were used in the simulations as a numerical perturbation method to realistically mimic the observed dense plume fingering. The HydroGeoSphere code coupled with PEST are used to calibrate the parameter set that defines the benchmark. A grid convergence analysis is performed to obtain the adequate spatial and temporal discretizations. The new mathematical benchmark is useful for model comparison and testing of variably saturated variable-density flow in porous media. Simmons CT, Pierini ML, Hutson JL (2002) Laboratory investigation of variable-density flow and solute transport in unsaturated–saturated porous media. Transp Porous Media. 47(2): 215–244, 10.1023/A:1015568724369.
Case report: PRES associated with fruquintinib in a patient with metastatic colon cancer
Authors: Wang Lu , Zeng Zhaohao , Wu Zhiqiang 
Published: August 2023

AbstractPosterior reversible encephalopathy syndrome (PRES) is a rare, reversible neurological disease that is frequently associated with the use of targeted therapy agents. In this case study, we examine the development of posterior reversible encephalopathy syndrome (PRES) in a 44-year-old woman with metastatic colon cancer following 1 month of treatment with the vascular endothelial growth factor receptor (VEGFR) inhibitor, fruquintinib. The occurrence of PRES after 1 month of VEGFR inhibitor administration is a common phenomenon. However, it is noteworthy that this is the first reported case of PRES associated with fruquintinib. The patient’s neurological function improved upon discontinuing the drug for a week, but worsening was observed following a lower-dose fruquintinib treatment. This patient’s experience highlights the potential for neurological deterioration in those treated with fruquintinib, prompting physicians to consider the possibility of PRES. Notably, this may be the first reported case linking fruquintinib to the syndrome, underscoring the importance of recognizing the association between PRES and fruquintinib.
Identities of Inverse Chevalley Type for the Graded Characters of Level-Zero Demazure Submodules over Quantum Affine Algebras of Type C
Authors: Kouno Takafumi , Naito Satoshi , Orr Daniel 
Published: August 2023

AbstractWe provide identities of inverse Chevalley type for the graded characters of level-zero Demazure submodules of extremal weight modules over a quantum affine algebra of type C. These identities express the product $$e^{\mu } \text {gch} ~V_{x}^{-}(\lambda )$$

e
μ

gch

V

x

-

(
λ
)

of the (one-dimensional) character $$e^{\mu }$$

e
μ

, where $$\mu $$
μ
is a (not necessarily dominant) minuscule weight, with the graded character gch$$V_{x}^{-}(\lambda )$$

V

x

-

(
λ
)

of the level-zero Demazure submodule $$V_{x}^{-}(\lambda )$$

V

x

-

(
λ
)

over the quantum affine algebra $$U_{\textsf{q}}(\mathfrak {g}_{\textrm{af}})$$

U
q

(

g
af

)

as an explicit finite linear combination of the graded characters of level-zero Demazure submodules. These identities immediately imply the corresponding inverse Chevalley formulas for the torus-equivariant K-group of the semi-infinite flag manifold $$\textbf{Q}_{G}$$

Q
G

associated to a connected, simply-connected and simple algebraic group G of type C. Also, we derive cancellation-free identities from the identities above of inverse Chevalley type in the case that $$\mu $$
μ
is a standard basis element $${\varepsilon }_{k}$$

ε
k

in the weight lattice P of G.
A multi-depth spiral milli fluidic device for whole mount zebrafish antibody staining
Authors: Ye Songtao , Chin Wei-Chun , Ni Chih-Wen 
Published: August 2023

AbstractWhole mount zebrafish antibody staining (ABS) is a common staining technique used to localize protein information in a zebrafish embryo or larva. Like most biological assays, the whole mount zebrafish ABS is still largely conducted manually through labor intensive and time-consuming steps which affect both consistency and throughput of the assay. In this work, we develop a milli fluidic device that can automatically trap and immobilize the fixed chorion-less zebrafish embryos for the whole mount ABS. With just a single loading step, the zebrafish embryos can be trapped by the milli fluidic device through a chaotic hydrodynamic trapping process. Moreover, a consistent body orientation (i.e., head point inward) for the trapped zebrafish embryos can be achieved without additional orientation adjustment device. Furthermore, we employed a consumer-grade SLA 3D printer assisted method for device prototyping which is ideal for labs with limited budgets. Notably, the milli fluidic device has enabled the optimization and successful implementation of whole mount zebrafish Caspase-3 ABS. We demonstrated our device can accelerate the overall procedure by reducing at least 50% of washing time in the standard well-plate-based manual procedure. Also, the consistency is improved, and manual steps are reduced using the milli fluidic device. This work fills the gap in the milli fluidic application for whole mount zebrafish immunohistochemistry. We hope the device can be accepted by the zebrafish community and be used for other types of whole mount zebrafish ABS procedures or expanded to more complicated in situ hybridization (ISH) procedure.
Graphical Abstract
Social Acceleration: A Challenge for Companies? Insights for Business Ethics from Resonance Theory
Authors: Hollstein Bettina , Rosa Hartmut 
Published: August 2023

AbstractIn modern capitalist societies, companies are exposed to enormous pressure to accelerate. However, it has increasingly become apparent that the social and economic acceleration which is the result of systemic imperatives tends to produce conflict both on the micro-level of personal temporal patterns and rhythms and on the macro-ecological level, where it tends to undermine the proper times for natural regeneration and reproduction. Corporations are increasingly called upon as corporate citizens to fulfil their responsibilities to stakeholders such as employees or ecosystems. Business ethics approaches therefore seek to develop strategies for fulfilling this responsibility in view of these conflicts created by social acceleration. In this contribution, we first present a diagnosis of acceleration imperatives for companies based on a sociological analysis of social acceleration. Then we examine the normative aspects of conflicts created by acceleration for employees and the ecosphere using the sociological conception of resonance. We attempt to articulate conceptually the normative requirements for a business ethics which are capable of dealing with the problems of social acceleration in corporations with a particular focus on a resonant stakeholder approach.
Mixed reality training application to perform obstetric pulsed-wave Doppler ultrasound
Authors: Nylund Maria Emine , Jain Shubham , Tegnander Eva , Jensen Eva Johanne Leknes , Prasolova-Førland Ekaterina , Linsdeth Frank , Kiss Gabriel 
Published: August 2023

AbstractPulsed-wave Doppler ultrasound is a widely used technique for monitoring pregnancies. As ultrasound equipment becomes more advanced, it becomes harder to train practitioners to be proficient in the procedure as it requires the presence of an expert, access to high-tech equipment as well as several volunteering patients. Immersive environments such as mixed reality can help trainees in this regard due to their capabilities to simulate real environments and objects. In this article, we propose a mixed reality application to facilitate training in performing pulsed-wave Doppler ultrasound when acquiring a spectrogram to measure blood velocity in the umbilical cord. The application simulates Doppler spectrograms while the trainee has the possibility of adjusting parameters such as pulse repetition frequency, sampling depth, and beam-to-flow angle. This is done using a combination of an optimized user interface, 3D-printed objects tracked using image recognition and data acquisition from a gyroscope. The application was developed for Microsoft HoloLens as the archetype of mixed reality, while a 3D-printed abdomen was used to simulate a patient. The application aims to aid in both simulated and real-life ultrasound procedures. Expert feedback and user-testing results were collected to validate the purpose and use of the designed application. Design science research was followed to propose the intended application while contributing to the literature on leveraging immersive environments for medical training and practice. Based on the results of the study, it was concluded that mixed reality can be efficiently used in ultrasound training.
Shifts in student attention on algorithmic and creative practice tasks
Authors: Norqvist Mathias , Jonsson Bert , Lithner Johan 
Published: August 2023

AbstractIn mathematics classrooms, it is common practice to work through a series of comparable tasks provided in a textbook. A central question in mathematics education is if tasks should be accompanied with solution methods, or if students should construct the solutions themselves. To explore the impact of these two task designs on student behavior during repetitive practice, an eye-tracking study was conducted with 50 upper secondary and university students. Their eye movements were analyzed to study how the two groups shifted their gaze both within and across 10 task sets. The results show that when a solution method was present, the students reread this every time they solved the task, while only giving minute attention to the illustration that carried information supporting mathematical understanding. Students who practiced with tasks without a solution method seemed to construct a solution method by observing the illustration, which later could be retrieved from memory, making this method more efficient in the long run. We discuss the implications for teaching and how tasks without solution methods can increase student focus on important mathematical properties.
Performance efficiency of some biocontrol agents on controlling Cercospora leaf spot disease of sugar beet plants under organic agriculture system
Authors: Ahmed M. F. A. , Mikhail Sherin P. H. , Shaheen S. I. 
Published: August 2023

AbstractThis investigation was carried out on commercial organic field in the Fayoum Governorate of Egypt under conditions of natural infection, 2020/2021 and 2021/2022 to evaluate the effectiveness of four commercial biocides—Blight Stop (Trichoderma harzianum), Bio Zeid (T. album), Root Guard (Bacillus subtilis), and Bio ARC (B. megaterium)—as well as, four biocontrol agents (T. harzianum, T. album, B. subtilis, and B. megaterium) in controling Cercospora beticola Sacc, the main causal of Cercospra leaf spot (CLS) disease on sugar beet in an organic farming systems. All biocontrol agents and commercial biocides sprayed at the recommended dose in a two spray regime with 15 days between sprays, were significantly reduced Cercospora beticola, total amino acid and juice impurities (K, Na and α-a N %) in comparison to control treatment. All bioagents and biocides put to the test resulted in a significant rise in phenolic compound values, total chlorophyll, sucrose (%), purity (%), root, top and sugar yield quality of sugar beet during both seasons. Spraying Blight Stop was the most effective treatment followed by T. harzianum. B. megaterium was the least effective biocide treatment compared with the control treatment during the two growing seasons.
The economics of the global minimum tax
Authors: Schjelderup Guttorm , Stähler Frank 
Published: August 2023

AbstractThis paper shows that OECD’s Pillar Two may increase employment and investment in low-tax countries due to the Substance-based Income Exclusion (SBIE). The SBIE allows to tax-deduct payroll costs and user costs of tangible assets twice from the tax base of the top-up tax owed by subsidiaries in low-tax countries. Consequently, it implies that a 15% minimum corporate tax for low-taxed subsidiaries is not achieved if the SBIE is positive. We show that Pillar Two dampens tax-motivated transfer pricing, but changes the employment, investment and import incentives, and that for a sufficiently large cost share of labor and/or capital, the SBIE is equivalent to a production subsidy.
Too complex to digest? Federal tax bills and their processing in US financial markets
Authors: Bennani Hamza , Neuenkirch Matthias 
Published: August 2023

AbstractIn this paper, we analyze whether the textual complexity of tax bills affects financial markets. Based on the Flesch-Kincaid grade level of the 32 tax bills identified by Romer (Am Econ Rev 100(3):763–801, 2010)in the period 1962–2003, we assess the relationship between tax bills’ textual complexity and financial markets in various windows around the signing of a bill. Our results show a negative (positive) and significant relationship between the present value of tax bills and changes in the 10-year government bond yields (S &P 500 returns). The magnitude of this relationship increases over time, suggesting that market participants underreact at first and need a couple of days to digest the information contained in the tax bills. This delay can be explained by the textual characteristics of the bills in the case of the 10-year yields as a lower readability partly counteracts the negative relationship for up to three days after the signing of a tax bill. In the case of the stock market, we find similar evidence, but only for a part of the readability measures employed in this paper.
High Performers = Better Leaders? Evidence From 55 Years of Professional Soccer on the Validity of Performance-based Promotion to Leader Positions
Authors: Schleu Joyce Elena , Krumm Stefan , Zerres Alfred , Hüffmeier Joachim 
Published: August 2023

AbstractPromoting high-performing employees to leadership positions is a pervasive practice and has high face validity. However, little is known about the actual link between employee and subsequent leader performance as prior results are inconsistent. Given the prevalence of this performance-based promotion strategy, we conducted a study to address this inconsistency. To account for prior diverging results, we (a) competitively tested predictions from different theoretical perspectives (i.e., the performance requirements perspective, the follower-centric perspective, and the Theory of Expert Leadership), (b) considered possible changes in the predictive validity of this strategy over time, and (c) included job complexity as potential moderator of the link between employee and subsequent leader performance. In a high stakes context (i.e., the first German soccer league), we tested the predictive validity of employee performance for leader performance. Our results suggest a low validity of performance-based promotion, as we could not find evidence for a link between employee performance and leader performance—neither initially following the promotion nor over time, which is most in line with the performance requirements perspective. We, thus, caution against the (sole) application of performance-based promotion principles.
Mono No Aware: How Conservatives Should do Change
Authors: Jenkins David 
Published: August 2023

AbstractIn this paper, I describe a conservative disposition to change which is capable of operating alongside three other dispositions: First, a disposition to accept a degree of epistemic humility with respect to the kinds of change that count as an ‘intimation’ or continuation of the value contained in some given situation. Second, a disposition to acknowledge the legitimacy of democratic majorities, even when these are not always expressions of those ‘intimations’ or continuations. Third, the disposition to help alleviate recognizable injustices as these might be suffered—and understood—by minorities. A conservative disposition to preserve the value of some given status quo operates in tension with these other three, and can sometimes give way to those other dispositions. An important part of managing tensions between these dispositions is an additional practice of reconciliation, one that helps conservatives treat change in properly conservative ways. I develop an account of this practice through a reading of Junichiro Tanizaki’s In Praise of Shadows and the Japanese concept of mono no aware. I argue Tanizaki’s work offers an approach to change that is conservative in spirit while still being capable of accommodating itself to change which will reduce—and even eliminate—things of value that were possible prior to that change.