bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequencing intact membrane proteins using MALDI mass spectrometry
Authors: Zhamungui Sánchez Edison , Hijazi Hassan , Haidar Jana , Mecarelli Enrica , Bauda Elda , Petit-Härtlein Isabelle , Teulon Jean-Marie , Pellequer Jean-Luc , Boeri Erba Elisabetta 
Published: July 2023

Membrane proteins are key players in many cellular events and represent crucial drug targets. Matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) is a valuable approach to investigate them. To our knowledge, there are only a few reports of sequencing small membrane proteins using MALDI in-source decay (ISD). We report the successful fragmentation and sequencing of membrane proteins up to 46 kDa by MALDI-ISD. We have 1) investigated key MALDI parameters that influence the sequencing of a soluble protein; 2) used atomic force microscopy to observe our samples and correlate their topological features with MALDI data, which allowed us to optimize fragmentation conditions; 3) sequenced N- and C-termini of three membrane proteins (SpoIIIAF, TIM23, and NOX), solubilized in three different ways. Our results indicate that detergent and buffer type are of key importance for successful MALDI-ISD sequencing. Our findings are significant because sequencing membrane proteins enables the unique characterization of challenging biomolecules. The resulting fragmentation patterns provide key insights into the identity of proteins, their sequences, modifications, and other crucial information, such as the position of unexpected truncation.
Effectiveness of exercise therapy on pain relief and jaw mobility in patients with pain-related temporomandibular disorders: a systematic review
Authors: Shimada Akiko , Ogawa Toru , Sammour Sara Reda , Narihara Taichi , Kinomura Shiori , Koide Rie , Noma Noboru , Sasaki Keiichi 
Published: July 2023

BackgroundOrofacial pain conditions are complex disorders that involve biological, social, and psychological factors. Temporomandibular Disorders (TMDs) are one of the most common orofacial pain conditions, and our previous literature review indicated that exercise therapy has shown promise in reducing TMD-related pain. However, more evidence is needed to firmly establish its effectiveness.ObjectivesThis systematic review aims to investigate the effectiveness of exercise therapy on pain relief and jaw mobility in patients with pain-related TMDs.MethodsTo include randomized controlled trials (RCTs) written in English, a literature search was performed using PubMed, Scopus, Web of Science, Cochrane Library, Ovid, EBM reviews, and Academic Search Complete initially from 4th November 2020 until March 2022. A PICOS for this review was as follows; P: Patients with TMD myalgia or arthralgia, I: Excursion exercise, Stretch exercises, Resistance exercise, or Coordination exercise, C: No treatment or education only. O: Pain intensity and Range of Motion (ROM), S: RCTs. After title screening, a full-text assessment was done to extract data. According to Risk of Bias (RoB) 2.0, risk of bias was assessed in each included paper by 2 reviewers independently.ResultsA total of 3,388 titles were identified from the electronic database search. After the screening and full-text evaluation, only 5 studies (145 participants) were eligible to be included. Among the exercise modalities, coordination exercise showed a significant effect on pain relief and improvement of joint mobility.DiscussionDue to the heterogeneity and small sample size of the included studies, a meta-analysis was not feasible. However, this systematic review suggested that exercise therapy, especially coordinate exercise, can be effective in managing painful TMD conditions. Further research is needed to establish optimal parameters for this patient population, as well as standardization and consistency in terminology and treatment structure.
Complicated enterocele: timely resolution with bowel resection via a vaginal approach: case report
Authors: Abis Paola , Madeddu Clelia , Magro Malosso Giovanni , Sole Gabriele , Mereu Alessia , Locci Giorgia , Macciò Antonio 
Published: July 2023

BackgroundEnterocele is an uncommon, serious condition that requires accurate and early diagnosis to prevent complications such as intestinal obstruction, incarceration, and strangulation, with consequent intestinal ischemia, necrosis, and evisceration. We report a rare case of a patient with a voluminous enterocele and initial signs of intestinal ischemia who underwent urgent vaginal surgery.Case descriptionAn 80-year-old woman presented with a voluminous mass protruding from the vagina, associated abdominopelvic pain, a 10-day history of bowel sub-occlusion, and numerous episodes of profuse vaginal bleeding. She was diagnosed with an enterocele with early signs of complications. Owing to her advanced clinical condition and comorbidities, we opted for an urgent vaginal procedure. Intestinal loops with initial signs of ischemia were resected via a transvaginal approach, leading to good clinical outcomes. She was discharged on postoperative day 5.ConclusionsThis rare case highlights a surgical emergency that was managed with transvaginal resection of the intestine. Early identification of the initial signs of complications allowed for this less invasive approach, resulting in reduced morbidity and length of hospital stay.
Study of Zoonotic Pathogens in Alien Population of Veiled Chameleons (Chamaeleo calyptratus) in the Canary Islands (Spain)
Authors: Pino-Vera Román , Abreu-Acosta Néstor , Foronda Pilar 
Published: July 2023

Veiled chameleons (Chamaeleo calyptratus) are native to the Arabian Peninsula that have been introduced as pets in many regions around the world, such as the Canary Islands (Spain). In this work, the gastrointestinal content from veiled chameleons of Gran Canaria island (Canary Islands) has been analyzed to determine the presence of zoonotic bacteria. Forty animals were analyzed using different selective culture media and PCR. The most isolated bacteria were Yersinia enterocolitica (52.4%), followed by Salmonella spp. (40.0%), with positive isolates for Salmonella Tyhpi and Salmonella Typhimurium. Pseudomonas spp. was found in 32.5% of the chameleons. More than half were positive for Pseudomonas aeruginosa. Antibiotic-resistant Staphylococcus spp. was detected in six animals plus one isolate of non-resistant Staphylococcus hominis. Multiple mycobacteria species belonging to both tuberculous and non-tuberculous complexes were identified as well as Escherichia coli carrying the stx1 and eae virulence genes with 12.5% and 7.5% prevalence, respectively. Listeria monocytogenes, Campylobacter spp., and Vibrio spp. were found in lower proportion (<5%). The results obtained indicate that veiled chameleons in Gran Canaria could be playing a role in the maintenance and dissemination of the pathogens detected, harming public health and biodiversity.
A Comparative Study of Optimal Individual Pitch Control Methods
Authors: Routray Abhinandan , Sivakumar Nitin , Hur Sung-ho , Bang Deok-je 
Published: July 2023

Wind turbines are subjected to asymmetric loads and fatigue with subsequent increases in their dimension and capacity, leading to a reduction in their lifetime. To address this problem, the individual pitch control (IPC) technique is quite familiar in the control of wind turbines. IPC is used to reduce the tilt and yaw moments, simultaneously alleviating the turbine blade-root bending moments (BRBMs). This study discusses the performance of model predictive control (MPC), H-infinity (H∞), and proportional and integral (PI)-based IPC strategies integrated with collective pitch control. The performance of the reported controllers has been validated using the National Renewable Energy Laboratory (NREL) 5 MW full nonlinear reference wind turbine. Simulation studies are conducted at varying wind speeds and turbulent intensities as per international electrotechnical commission (IEC) norms. Comparative results in the time and frequency domains indicate that the H∞ based IPC achieves enhanced control performance in terms of reduction in BRBMs and damage equivalent load compared to MPC and PI-based control strategies.
IMPROVING THE EFFICIENCY OF CEMENT FURNACE BANDAGES REPAIR TECHNOLOGY THROUGH THE USE OF A NEW PROCESSING MODULE DESIGN
Authors: Timofeev S. 
Published: July 2023

During the operation of large-sized kilns of cement plants, due to the design features and operating conditions, there is constant wear of the rolling surfaces of its supports, consisting of support rollers and bandages. A decrease in the accuracy of the shape caused by the wear of these surfaces can lead to distortion of the shape of the entire unit and its failure. To eliminate wear and bring the shape of the supports to the standard values of geometric tolerances, there are various technological processes of mechanical processing. The most effective of them are non-dismountable mobile repair technologies. A distinctive feature of this type of technological processes is that the machining of the rolling surface of the supports is carried out directly during the technological rotation of the firing furnaces, without stopping them.
Subject to the use of existing methods for measuring the shape of the rolling surface of the bandages, the possibility of increasing the efficiency of their machining due to the integrated use of a new design of the processing module and a software module for constructing a route and calculating technological cutting modes is shown. The paper considers the main stages and methods of performing a new technological process of mechanical surface treatment of rolling bands of firing furnaces.
Assessment of Vitamin D Status in Women with Endometrial Hyperplastic Processes in Perimenopause
Authors: Абдыева Ф.В. 
Published: July 2023

При анализе проведенного лечения препаратом D-Colerol было установлено, что достаточный уровень 25(ОН)D (>30 нг/мл) в основной группе (n=50) отмечался у 39 (78,0±5,9%) пациенток, у 11 пациенток (22,0±5,9%) диагностировали недостаточность (10–29 нг/мл), а тяжелый дефицит витамина D (<10 нг/мл) в данной группе уже не отмечался. В группе сравнения (n=30) достаточный уровень 25(ОН)D (>30 нг/мл) отмечался у 26 (86,7±6,1%) пациенток, у 4 пациенток (13,3±6,1%) диагностировали недостаточность (10–29 нг/мл), тяжелый дефицит витамина D (<10 нг/мл) в данной группе не отмечался. Формирование недостаточности витамина D в перименопаузальном периоде можно предотвратить приемом D-Colerol, Oral Drops, 50000 МЕ/15 ml (Vitamin D3). Рекомендовано продолжать прием препаратов в течение 3 месяцев с дальнейшим контролем уровня витамина D и Са в крови в динамике. Наличие дефицита витамина D необходимо учитывать при определении тактики ведения пациенток с гиперпластическими процессами эндометрия.
When analyzing the treatment with D-Colerol, it was found that a sufficient level of 25(OH) D (>30 ng/ml) in the main group (n=50) was observed in 39 (78.0±5.9%) patients, in 11 patients (22.0±5.9%) were diagnosed with deficiency (10–29 ng/ml), and severe vitamin D deficiency (<10 ng/ml) was not observed in this group of patients. In the comparison group (n=30), a sufficient level of 25(OH)D (>30 ng/ml) was observed in 26 (86.7±6.1%) patients, in 4 patients (13.3±6.1%) were diagnosed with deficiency (10–29 ng/ml), severe vitamin D deficiency (<10 ng/ml) was not observed in this group. The formation of vitamin D deficiency in the perimenopausal period can be prevented by taking D-Colerol, Oral Drops, 50,000 IU/15 ml (Vitamin D3). It is recommended to continue taking the drugs for 3 months with further monitoring of the level of vitamin D and Ca in the blood in dynamics. The presence of vitamin D deficiency must be taken into account when determining the tactics of managing patients with endometrial hyperplastic processes.
Pengaruh Karet Remah Terhadap Stabilitas Campuran Beraspal Laston AC-WC Menggunakan Metode Dry Mix
Authors: Ulfah Luthfiyyah 
Published: July 2023

Roads must have the appropriate mix of thickness and design to protect the subgrade from damage and to accommodate the load pressure on the road. The purpose of this research is to investigate the effects of adding crumb rubber to the hot asphalt mixture of the Laston AC-WC type. The research was conducted in two stages, involving the creation of test specimens. In the first stage, the bitumen content of the specimens included 5%, 5.5%, 6%, 6.5%, and 7%. In the second stage, In the second stage, crumb rubber was added to the mixture at percentages: 0%, 5%, 10%, 15%, and 20%. The crumb rubber was mixed using the dry mix method. Several parameters were considered based on the results of the Marshall Test, in accordance with the General Highways specifications (VFA, VIM, VMA, Stability, Meltability and MQ). characteristics analysis aims to determine the impact of crumb rubber content on the elasticity, durability, and other properties of the asphalt mixture. Of all the variations of the hot mix asphalt type Laston AC-WC mixed with crumb rubber; the optimum level of crumb rubber mixture was obtained at 5% for the hot mix asphalt type Laston AC-WC. From the research results, when 5% crumb rubber was added to the asphalt mixture, the following values were obtained: 856.1 kg stability, 3.07 mm flow and 290.40 kg/mm MQ. In contrast, the stability value of hot asphalt concrete asphalt concrete type AC-WC with 5% asphalt has 813.7 kg stability, 3.03 mm flow and 268.30 kg/mm MQ.
Efficient treatment of surface runoff
Authors: Сухомлинов В.П. , Мелехов Р.В. , Голосняков В.П. 
Published: July 2023

Опыт практической эксплуатации проточных систем очистки поверхностных сточных вод в различных реальных условиях на территории РФ показал их полную технологическую несостоятельность. По оценке специалистов, технологические и конструктивные параметры установок проточного типа не соответствуют нормам проектирования, действующим в РФ, заявленная степень очистки поверхностных сточных вод на них недостижима, то есть, по сути, проточные системы осуществляют имитацию очистных процессов. Наряду с традиционным набором загрязнений (песок, взвешенные вещества, нефтепродукты и тяжелые металлы), характерных для поверхностных сточных вод, реальную угрозу водным объектам, принимающим ливневой сток, представляет микропластик. Технологическая несостоятельность проточных систем очистки и новые объективные задачи по очистке поверхностных сточных вод от дополнительных видов загрязнений диктуют необходимость применения надежных технологических решений.
The experience of practical operation of flow-through systems for surface runoff treatment in different real-life environment on the territory of the Russian Federation showed their complete technological failure. In the estimation of specialists, the process and design parameters of flow-through plants do not comply with the design standards in force in the Russian Federation, the declared degree of surface runoff treatment being unachievable; that is, virtually, flow-through systems simulate treatment processes. Along with the traditional set of pollutants typical for surface runoff (sand, suspended solids, oil products and heavy metals), microplastics pose a real threat to water bodies that receive storm water. Technological inconsistency of flow-through treatment systems and new objective tasks of removing additional types of pollution from surface runoff necessitate the use of reliable process solutions for the treatment of surface runoff.
Pendampingan Proses Produk Halal (PPH) dalam Program SEHATI (Sertifikasi Halal Gratis) pada Produk Dapoer Nyo-Nya
Authors: Sup Devid Frastiawan Amir 
Published: July 2023

Umat Islam menginginkan setiap produk wajib memiliki sertifikasi halal, artinya telah memenuhi standar kelayakan dan sesuai dengan syarat halal suatu produk menurut agama Islam. Masa penahapan pertama kewajiban sertifikat halal akan berakhir pada 17 Oktober 2024. Terdapat 3 (tiga) kelompok produk yang harus sudah bersertifikat halal seiring dengan berakhirnya penahapan pertama tersebut, produk makanan dan minuman, bahan baku, bahan tambahan pangan, dan bahan penolong untuk produk makanan dan minuman, serta produk hasil sembelihan dan jasa penyembelihan. Pendampingan PPH merupakan kegiatan untuk membantu pelaku usaha mikro dan kecil dalam memenuhi persyaratan pernyataan kehalalan produk. Pelaku usaha yang didampingi adalah Ibu Inawati, dengan jenis produk berupa minuman dengan pengolahan dengan merek dagang Dapoer Nyo-Nya. Dalam pengajuan sertifikasi halal ini, Ibu Inawati mengalami kesulitan dalam menggunakan komputer/laptop dan internet. Metode pendampingan yang dilakukan adalah pengumpulan data pelaku usaha, identifikasi produk, identifikasi bahan-bahan yang digunakan dalam produk, penyusunan alur proses produksi, submit data melalui laman https://ptsp.halal.go.id, verifikasi dan validasi data oleh Pendamping PPH, dan pemantauan status pengajuan hingga terbit sertifikat halal. Berdasarkan hasil pendampingan yang dilakukan, produk tersebut dinyatakan memenuhi persyaratan untuk mendapatkan sertifikat halal dari Program SEHATI. Proses pengajuan sertifikasi halal ini dimulai pada tanggal 24 Mei 2022 dan terbit sertifikat halal pada tanggal 13 September 2022 dengan nomor sertifikat ID35110000376200522 dengan masa berlaku hingga 15 Juli 2026.
Formulation of carrotle (Daucus carota L.) scrub cream as anti-aging
Authors: Shufyani Fahma , Andry Muhammad , Tarigan Rida Evalina 
Published: July 2023

Pendahuluan: Wortel terkenal dengan kandungan beta karoten yang sangat tinggi pada buahnya disertai dengan kandungan vitamin lain yaitu vitamin B dan vitamin E. Peran vitamin E pada kulit meliputi sebagai antioksidan, menjaga kelembapan kulit, perlindungan terhadap sinar matahari, serta proses penyembuhan luka. Sebagai antioksidan alami, vitamin E mampu menangkal radikal bebas dan molekul oksigen. Tujuan: Untuk mengetahui sari wortel (Daucus carota L.) dapat diformulasikan sebagai krim lulur sebagai anti-aging serta untuk mengetahui pada konsentrasi berapa yang paling efektif dalam sediaan krim lulur sari wortel (Daucus carota L.) sebagai anti-aging. Metode: Jenis penelitian ini dilakukan secara eksperimental. Penelitian ini meliputi pengumpulan responden, pengukuran kadar air, kehalusan, pori, noda, dan keriput pada kulit responden, pembuatan sari wortel, pembuatan sediaan lulur dari sari wortel dan uji evaluasi sediaan. Hasil: Penggunaan sediaan krim lulur yang mengandung sari wortel (Daucus carota L.) konsentrasi 15% selama 4 minggu menunjukkan perubahan kondisi kulit menjadi lebih baik dengan kadar air meningkat 19,3 menjadi 40 (107,25%), kehalusan kulit yang semakin halus 36,3 menjadi 20,6 (43,25%), pori-pori semakin mengecil 64 menjadi 20,6 (67,81%), banyak noda semakin berkurang 51 menjadi 11,3 (77,97%), kerutan yang semakin berkurang pada kulit responden menjukkan hasil yang lebih baik didapatkan yaitu perubahan kerutan 45 menjadi 13,6 dengan persen pemulihan sebesar (69,77%). Kesimpulan: Kesimpulan dari penelitian ini adalah Sari wortel (Daucus carota L.) dapat diformulasikan sebagai krim Lulur sebagai anti aging.
PENGARUH PELATIHAN, KUALITAS SUMBER DAYA MANUSIA DAN PENGETAHUAN AKUNTANSI TERHADAP EFEKTIVITAS PENERAPAN APLIKASI SISTEM PENGELOLAAN ASET DESA (SIPADES) SE-KECAMATAN TEMPUREJO KABUPATEN JEMBER
Authors: Laksana Bagas Tegar , Yuliartati Norita Citra , Suharsono Riyanto Setiawan 
Published: July 2023

Sistem Pengelolaan Aset Desa (SIPADES) merupakan aplikasi yang resmi dari Pemerintah Indonesia yang dikembangkan oleh Ditjen Binapemdes untuk digunakan oleh seluruh Pemerintah Desa dalam pengelolaan aset desa sesuai peraturan perundangan-undangan yang berlaku. Berdasarkan mini oberservasi yang dilakukan pada desa-desa di Kecamatan Tempurejo, penerapan SIPADES yang dilakukan secara digital masih terdapat kendala, sehingga hal ini menyebabkan hasil penerapan sistem belum maksimal. Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan, kualitas SDM, dan pengetahuan akuntansi terhadap efektivitas penerapan SIPADES se-Kecamatan Tempurejo Kabupaten Jember. Populasi dalam penelitian ini adalah perangkat desa atau operator SIPADES yang berjumlah 30 orang. Teknik sampel yang dipakai adalah sampel jenuh, dimana keseluruhan populasi dijadikan sampel, sehingga sampel yang dipakai sebanyak 30 orang. Jenis penelitian ini adalah deskriptif dengan pendekatan kuantitatif. Data yang digunakan adalah data primer yang diperoleh dari jawaban kuesioner. Teknik analisis yang digunakan adalah regresi linier berganda dengan menggunakan aplikasi SPSS versi 25. Hasil dari penelitian ini menunjukkan bahwa variabel pelatihan dan variabel kualitas sumber daya mansuia berpengaruh terhadap efektivitas penerapan aplikasi SIPADES, sedangkan variabel pengetahuan akuntansi tidak berpengaruh terhadap efektivitas penerapan aplikasi SIPADES se-Kecamatan Tempurejo Kabupaten Jember
Analisis Peranan Jati Diri Koperasi Sebagai Wujud Pengimplementasian Good Corporate Governance (GCG) Koperasi di Indonesia
Authors: Nurkholis Kgs. M. , Meiriasari Vhika , Hendarmin R.M. Rum 
Published: July 2023

The long history of cooperatives that existed in the pre-independence era required cooperatives to always make formulas in the form of standard rules that were systematically compiled by the government and other authorities so that cooperatives could continue to play a role in building the nation's economy which has been reflected in the identity of cooperatives. Cooperative identity is reflected in three approaches, namely the essentialist approach, the institutional approach and the nominalist approach. The identity of a cooperative is actually a complex conceptual arrangement so that if the identity of a cooperative is properly implemented, a true cooperative will run according to its main corridor, namely the welfare of its members and society. Governance systems or devices known as Good Corporate Governance according to The Organization Cooperation and Development (OCD) consist of principles and characteristics that can be used as a whole (universal) consisting of culture, environmental differences and systems of laws and regulations and values -values that exist and apply in a country. Based on several studies, the researchers concluded that this crisis occurred due to a failure in implementing good corporate governance. However, there is one solution in alleviating the economic crisis, in which there is a role for the people to help each other and work together in creating a sovereign economy. which complement each other. This cannot be separated because the identity of cooperatives has become a characteristic of cooperatives from the times when ideas about cooperatives have developed and spread throughout the world.
Keywords: Identity, Cooperative, Good Corporate Governance
Determinan Fraud pada Persepsi Pegawai Perbankan dengan Budaya Organisasi sebagai Variabel Intervening
Authors: Putra Berry , Adam Mohamad , Meutia Inten 
Published: July 2023

Pembahasan tentang terjadinya tindakan fraud di sektor perusahaan perbankan yang dimana menitikberatkan keterkaitan dengan kompensasi, pengendalian internal, kompetensi pegawai sebagai indikator independen dan variabel budaya organisasi menjadi media interventing. Studi ini mengambil persepsi dari 238 pegawai bank dengan menggunakan metode kuesioner sampel purposive (purposive sampling) dengan jumlah pertanyaan sebanyak 34 pertanyaan. Dalam penelitian ini menggunakan teknik analisis metode Structural Equation Modeling (SEM) dengan pendekatan Partial Least Square (PLS) yang menggunakan software smartPLS 3. Hasil survei menunjukkan bahwa variabel hasil efek total koefisien menunjukkan bahwa kompensasi, pengendalian internal dan kompetensi memilki pengaruh terhadap budaya organanisasi. Sedangkan dalam pengujian uji jalur dimana budaya organisasi mampu menjadi interventing atau sebagai mediasi terhadap tindakan terjadinya fruad. Dalam hal untuk mencegah tindakan akan terjadinya fraud dalam perusahaan perbankkan perlu adanya pengetatan sebuah peraturan dan kebijakan yang dibuat baik dari pihak internal ataupun eksternal perusahaan. Selain itu perlu diadaknya sosialisasi untuk para karyawan perihal bahaya tindakan fraud.