bluuebunny/crossref_metadata_2025_split huggingface dataset:
LITERASI FITUR DATA-FORM MS. EXCEL UNTUK MENGELOLA DATABASE ANGGOTA PERKUMPULAN KEMATIAN “LAZARUS” MALANG
Authors: Wardani Tri Istining , Rachmi Asminah , Sudjanarti Dwi , Khabibah Umi , Zaini Achmad 
Published: January 2023

This community service aims to develop technical skills in managing databases. So far, the “Lazarus" commission processed all regular membership fees manually. The repetitive work and recording errors happened along the way. With a total of 428 family members out of 993, the above data processing was inefficient and ineffective.
Ms. Excel, especially the Data-Form feature will make database management easier for someone to process data entry, edit, search, and delete in a database table. When a database has been formed, the preparation of the annual report will also be able to be compiled efficiently & effectively, because the database is already stored in a soft file.
Community service is carried out through training assistance. The activity begins with preparing teaching modules, followed by assisting to create a table model database in Ms. Excel. Subsequently, design a Data (Entry) Form model for recapitulation.
The competencies have been achieved because in the end the database management has been simulated very well using real data & problems. Therefore, the final evaluation results declared that the database management model uses the Data Form successfully to help the "Lazarus" commission maximize its service.
Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico
Authors: Estrada Reyes Elizabeth , Zepeda Ortega Benjamín , ten Haaf Dominique , Kudla Urszula , Muhardi Leilani , Hofman Denise L. , Hageman Jeske H. J. , Huerta Hernández Rosa E. 
Published: January 2023

BackgroundCow's milk protein allergy (CMPA) is the leading cause of food allergy in infants and young children. An extensively hydrolyzed formula (eHF) is the first choice of dietary management, however, not all of them have similar peptide profiles and degree of hydrolysis. The aim of this retrospective study was to investigate the use of two commercially available infant formulas in the clinical management of CMPA in Mexico in terms of symptoms' resolution and growth trajectories.MethodsMedical records of 79 subjects from four sites in Mexico were included to retrospectively evaluate the trajectory of atopic dermatitis, other symptoms of cow's milk protein allergy and growth outcomes. The study formulas were based on hydrolyzed whey protein (eHF-W) and hydrolyzed casein protein (eHF-C).ResultsMedical records of 79 patients were enrolled, 3 were excluded from analysis based on previous formula consumption. Seventy-six children with confirmed CMPA based on skin prick test and/or serum specific IgE levels were included in the analysis. 82% of patients (n = 65) consumed the eHF-C, reflecting the doctors' preference for formulas with a higher grade of hydrolysis and the high incidence of positive reactions to beta-lactoglobulin amongst subjects. During their first visit to the doctors, 55% of the subjects consuming the casein-based formula and 45% of subjects consuming the whey-based formula presented with mild or moderate dermatological symptoms. Other frequently reported symptoms included respiratory issues, enteropathies and colitis which improved during the consumption of both formulas. All CMPA-related symptoms showed improvement during formula consumption. During the period of retrospective observation, growth significantly improved for both groups.ConclusionConsumption of eHF-C and eHF-W effectively improved symptoms' resolution and growth outcomes among children with CMPA in Mexico. More preference was reported towards eHF-C due to its hydrolysate profile and lack of b-lactoglobulin.Trial registrationThe study was registered at ClinicalTrials.gov: NCT04596059.
Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome
Authors: Alcayaga-Miranda Francisca , Dutra Silva Johnatas , Parada Nicol , Andrade da Silva Luisa Helena , Ferreira Cruz Fernanda , Utreras Yildy , Hidalgo Yessia , Cádiz María Ignacia , Tapia Limonchi Rafael , Espinoza Francisco , Bruhn Alejandro , Khoury Maroun , R. M. Rocco Patricia , Cuenca Jimena 
Published: January 2023

Background: Treatment for critical care conditions, such as acute respiratory distress syndrome (ARDS), requires ready-to-administer injectable mesenchymal stromal cells (MSCs). A validated cryopreserved therapy based on MSCs derived from menstrual blood (MenSCs) is an attractive option that offers advantages over freshly cultured cells and allows its use as an off-the-shelf therapy in acute clinical conditions. The main goal of this study is to provide evidence on the impact of cryopreservation on different biological functions of MenSCs and to determine the optimal therapeutic dose, safety, and efficacy profile of clinical-grade, cryopreserved (cryo)-MenSCs in experimental ARDS.Methods: Biological functions of fresh versus cryo-MenSCs were compared in vitro. The effects of cryo-MenSCs therapy were evaluated in vivo in ARDS-induced (Escherichia coli lipopolysaccharide) C57BL/6 mice. After 24 h, the animals were treated with five doses ranging from 0.25×105 to 1.25×106 cells/animal. At 2 and 7 days after induction of ARDS, safety and efficacy were evaluated.Results: Clinical-grade cryo-MenSCs injections improved lung mechanics and reduced alveolar collapse, tissue cellularity, and remodelling, decreasing elastic and collagen fiber content in alveolar septa. In addition, administration of these cells modulated inflammatory mediators and promoted pro-angiogenic and anti-apoptotic effects in lung-injured animals. More beneficial effects were observed with an optimal dose of 4×106 cells/Kg than with higher or lower doses.Conclusion: From a translational perspective, the results showed that clinical-grade cryopreserved MenSCs retain their biological properties and exert a therapeutic effect in mild to moderate experimental ARDS. The optimal therapeutic dose was well-tolerated, safe, and effective, favouring improved lung function. These findings support the potential value of an off-the-shelf MenSCs-based product as a promising therapeutic strategy for treating ARDS.
Post-lacustrine evolution of a tectonically-controlled intermontane basin: Drainage network analysis of the Mercure basin, southern Italy
Authors: Gioia Dario , Corrado Giuseppe , Danese Maria , Minervino Amodio Antonio , Schiattarella Marcello 
Published: January 2023

Topographic analysis, drainage network morphometry, river profile analysis, and spatial distribution of fluvio-lacustrine terraces have been used to reconstruct the drainage network evolution in the Mercure River basin, a large intermontane tectonic basin of the axial zone of southern Apennines. Morphotectonic evolution of the study area is mainly controlled by poly-kinematics high-angle WNW-ESE and NE-SW faults, which promoted the development of a complex landscape with relict landscapes and/or low-relief erosional surfaces that occurred in a staircase arrangement at the top of the landscapes or at higher altitudes than the basin infill. The creation of the accommodation space for the deposition of the thick basin infill was related to an important tectonic phase of block-faulting along N120°-trending normal faults, which occurred in the final part of the Lower Pleistocene. Such an evolution strongly controls the longitudinal profile forms of channels draining the northern sector of the study area, which are featured by a well-developed concave-up segment in river profiles of these channels between an upward trait with lower values of channel steepness and the trace of the master fault. River profiles in north-western and south-east sectors of the Mercure River basin exhibit clear knickpoints at altitudes comparable with those of the superimposed orders of relict landscapes related to the initial formation of the tectonic basin and the subsequent evolution of the endorheic basin, with a post-lacustrine geomorphological evolution of the drainage network that is controlled by fluvial incision occurring at rates comparable than those reconstructed by independent morphotectonic markers. The erosion of the threshold of the endorheic basin occurring during the base-level fall of the MIS 12 promoted a dramatic base-level fall of about 150 m, which corresponds to a mean incision rate of about 0.35 mm/yr. Post-lacustrine evolution of the Mercure basin strongly controls the morphometric features of the drainage network, which preserves a centripetal pattern with several planimetric anomalies such as counterflow and high-angle confluences, local-scale fluvial capture phenomena and drainage divide migrations.
Dynamic changes in forest cover and human activities during the Holocene on the northeast Tibetan plateau
Authors: Wende Zhuoma , Hou Guangliang , Chen Hongming , Jin Sunmei , Zhuoma Lancuo 
Published: January 2023

Human activities strongly influenced the present-day environment of the Tibetan Plateau, especially in the northeastern area. The questions over when and to what extent humans began to utilize the plateau environment have been long investigated, but there are still gaps in our understanding, such as the relationship between forest dynamics and anthropogenic activities. Here, we simulate the potential Holocene geographical distribution of the three dominant coniferous species in the Northeast Tibetan Plateau in response to climate/environment and analyze pollen records and multi-proxies for anthropogenic activities to explore human impact on natural forest dynamics. Simulation results show marked expansion of Picea and Pinus coniferous forests in the Early Holocene (11.5–8.3 ka BP), continuing into the Mid Holocene (8.3–4.0 ka BP). However, there was a slight contraction of forest in the Late Holocene (4.0–2.6 ka BP) in the western part of the region, and near disappearance in the eastern Qaidam Basin, although both Pinus and Picea slightly increased in Hehuang Valley. Pollen analysis confirms the patterns, with an increase in arboreal pollen mainly comprising Pinus and Picea from Early to Early Mid Holocene (11.5–5.3 ka BP), followed by a decrease. Proxies of anthropogenic activities, including carbon concentration, archeological sites, and, synanthropic plants, increased significantly after 5.3 ka BP, with archeological evidence for intensive exploitation of forest and turnover of natural vegetation. We argue that forest retreat at 5.3–4.0 ka BP was due to the expansion of cropland and increasing demand for wood. Significant coniferous forest retreat and degradation from 4.0 to 2.6 ka BP, with forest succession in Hehuang Valley, was driven by the booming population, extensive grazing, and forest exploitation; the drying cooling climate may have aggravated the pace of deforestation at higher elevations. This study presents new insights into the deforestation on the Northeast Tibetan Plateau in the Holocene.
Clinical effectiveness of second-line antihyperglycemic drugs on major adverse cardiovascular events: An emulation of a target trial
Authors: Siriyotha Sukanya , Lukkunaprasit Thitiya , Angkananard Teeranan , Looareesuwan Panu , McKay Gareth J. , Attia John , Thakkinstian Ammarin 
Published: January 2023

IntroductionThe cardiovascular benefits of multiple antihyperglycemic drugs as add-on therapies to metformin in the real-practice are unclear. This study aimed to directly compare major adverse cardiovascular events (CVE) associated with these multiple drugs.MethodsAn emulation of a target trial was conducted using a retrospective-cohort data of type 2 diabetes mellitus (T2DM) prescribed with second-line drugs on top of metformin, including sodium-glucose cotransporter 2 inhibitors (SGLT2i), dipeptidyl peptidase-4 inhibitors (DPP4i), thiazolidinediones (TZD) and sulfonylureas (SUs). We applied inverse probability weighting and regression adjustment using intention-to-treat (ITT), per-protocol analysis (PPA) and modified ITT. Average treatment effects (ATE) were estimated using SUs as the reference.Results and DiscussionAmong 25,498 patients with T2DM, 17,586 (69.0%), 3,261 (12.8%), 4,399 (17.3%), and 252 (1.0%) received SUs, TZD, DPP4i, and SGLT2i. Median follow-up time was 3.56 (1.36-7.00) years. CVE was identified in 963 patients. The ITT and modified ITT approaches showed similar results; the ATE (i.e., the difference of CVE risks) for SGLT2i, TZD, and DPP4i compared to SUs were -0.020(-0.040, -0.0002), -0.010(-0.017, -0.003), and -0.004(-0.010, 0.002), respectively, indicating 2% and 1% significant absolute risk reduction in CVE in SGLT2i and TZD compared to SUs. These corresponding effects were also significant in the PPA with ATEs of -0.045(-0.060, -0.031), -0.015(-0.026, -0.004), and -0.012(-0.020, -0.004). In addition, SGLT2i had 3.3% significant absolute risk reduction in CVE relative to DPP4i. Our study demonstrated benefits of SGLT2i and TZD in reducing CVE in T2DM patients compared to SUs when added to metformin.
Transcriptomic analysis reveals the potential crosstalk genes and immune relationship between IgA nephropathy and periodontitis
Authors: Gao Xiaoli , Guo Ziyi , Wang Pengcheng , Liu Zhiqiang , Wang Zuomin 
Published: January 2023

BackgroundIt is well known that periodontitis has an important impact on systemic diseases. The aim of this study was to investigate potential crosstalk genes, pathways and immune cells between periodontitis and IgA nephropathy (IgAN).MethodsWe downloaded periodontitis and IgAN data from the Gene Expression Omnibus (GEO) database. Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were used to identify shared genes. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on the shared genes. Hub genes were further screened using least absolute shrinkage and selection operator (LASSO) regression, and a receiver operating characteristic (ROC) curve was drawn according to the screening results. Finally, single-sample GSEA (ssGSEA) was used to analyze the infiltration level of 28 immune cells in the expression profile and its relationship with shared hub genes.ResultsBy taking the intersection of WGCNA important module genes and DEGs, we found that the SPAG4, CCDC69, KRT10, CXCL12, HPGD, CLDN20 and CCL187 genes were the most important cross-talk genes between periodontitis and IgAN. GO analysis showed that the shard genes were most significantly enriched in kinase regulator activity. The LASSO analysis results showed that two overlapping genes (CCDC69 and CXCL12) were the optimal shared diagnostic biomarkers for periodontitis and IgAN. The immune infiltration results revealed that T cells and B cells play an important role in the pathogenesis of periodontitis and IgAN.ConclusionThis study is the first to use bioinformatics tools to explore the close genetic relationship between periodontitis and IgAN. The SPAG4, CCDC69, KRT10, CXCL12, HPGD, CLDN20 and CCL187 genes were the most important cross-talk genes between periodontitis and IgAN. T-cell and B-cell-driven immune responses may play an important role in the association between periodontitis and IgAN.
Hybrids of SiO2 substrate and electrospun Ni-MOF/polysulfone fibers for an efficient removal of CH4 gas pollution
Authors: Geesi Mohammed H. , Jalil Abduladheem Turki , Riadi Yassine , Aljohani Talal A. , Alameri Ameer A. 
Published: January 2023

In this study, novel nanostructures based on Ni-MOF/polysulfone nanofibers were fabricated by microwave-assisted electrospinning method. The final Ni-MOF/polysulfone fibrous nanostructure were immobilized on SiO2 substrates with high physicho-chemical properties. These nanostructures with an average diameter of 20 nm and a specific surface area of 1690 m2/g were used as novel adsorption for CH4 gas adsorption. It seems that the integration of novel Ni-MOF compounds into the fibrous network has differentiated these materials from previous samples. Since the experimental parameters significantly affect the specific surface area, the parameters including voltage, concentration, and distance between the collector and source are designed by the fractional factorial method. The results were optimized by contour plots, ANOVA and surface plots, theoretically. The results show that the sample has an adsorption rate of about 5.14 mmoL/g. The improved CH4 gas adsorption performance is attributed to the large specific surface area and porous nature of the Ni-MOF/Ps nanostructure which is more convenient and accessible for CH4 gas adsorption.
Development process of a clinical guideline to manage type 2 diabetes in adults by Ayurvedic practitioners
Authors: Chattopadhyay Kaushik , Kapoor Nitin , Heinrich Michael , Mitra Achintya , Mittal Madhukar , Lewis Sarah Anne , Greenfield Sheila Margaret , Mukherjee Shyamalendu , Pischel Ivo , Jeemon Panniyammakal , Tandon Nikhil , Kinra Sanjay , Biswas Tuhin Kanti , Leonardi-Bee Jo 
Published: January 2023

BackgroundType 2 diabetes mellitus (T2DM), a common chronic health condition, has major health and socioeconomic consequences. In the Indian subcontinent, it is a health condition for which individuals commonly consult Ayurvedic (traditional medical system) practitioners and use their medicines. However, to date, a good quality T2DM clinical guideline for Ayurvedic practitioners, grounded on the best available scientific evidence, is not available. Therefore, the study aimed to systematically develop a clinical guideline for Ayurvedic practitioners to manage T2DM in adults.MethodsThe development work was guided by the UK’s National Institute for Health and Care Excellence (NICE) manual for developing guidelines, the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, and the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. First, a comprehensive systematic review was conducted which evaluated Ayurvedic medicines’ effectiveness and safety in managing T2DM. In addition, the GRADE approach was used for assessing the certainty of the findings. Next, using the GRADE approach, the Evidence-to-Decision framework was developed, and we focused on glycemic control and adverse events. Subsequently, based on the Evidence-to-Decision framework, a Guideline Development Group of 17 international members made recommendations on Ayurvedic medicines’ effectiveness and safety in T2DM. These recommendations formed the basis of the clinical guideline, and additional generic content and recommendations were adapted from the T2DM Clinical Knowledge Summaries of the Clarity Informatics (UK). The feedback given by the Guideline Development Group on the draft version was used to amend and finalize the clinical guideline.ResultsA clinical guideline for managing T2DM in adults by Ayurvedic practitioners was developed, which focuses on how practitioners can provide appropriate care, education, and support for people with T2DM (and their carers and family). The clinical guideline provides information on T2DM, such as its definition, risk factors, prevalence, prognosis, and complications; how it should be diagnosed and managed through lifestyle changes like diet and physical activity and Ayurvedic medicines; how the acute and chronic complications of T2DM should be detected and managed (including referral to specialists); and advice on topics like driving, work, and fasting including during religious/socio-cultural festivals.ConclusionWe systematically developed a clinical guideline for Ayurvedic practitioners to manage T2DM in adults.
Exploring the challenges of virtual internships during the COVID-19 pandemic and their potential influence on the professional identity of health professions students: A view from Qatar University
Authors: Bawadi Hiba , Shami Rula , El-Awaisi Alla , Al-Moslih Ayad , Abdul Rahim Hanan , Du Xiangyun , Moawad Joyce , Al-Jayyousi Ghadir Fakhri 
Published: January 2023

IntroductionCOVID-19 has imposed many shared limitations on medical and health education. Just like other health professions programs at most institutions, the Qatar University health cluster (QU Health) applied a containment approach and shifted all learning online, and onsite training was replaced by virtual internships (VIs) during the first wave of the pandemic. Our study aims to explore the challenges of virtual internships during the COVID-19 pandemic and their influence on the professional identity (PI) of the health cluster students from the College of Medicine, the College of Health Sciences, and the College of Pharmacy at Qatar University.MethodsA qualitative approach was employed. In total, eight focus groups with students (N = 43) and 14 semi-structured interviews with clinical instructors from all the health cluster colleges were conducted. Transcripts were analyzed following the inductive approach.ResultsThe major challenges reported by students were mainly related to the lack of the required skills for navigating the VI, professional and social stressors, the nature of VIs and the quality of learning, technical and environmental issues, and the development of students' professional identity in an alternative internship environment. The challenges relating to the development of professional identity included: limited clinical (practical) experience, a lack of experience in fighting a pandemic, a lack of communication and feedback, and a lack of confidence in meeting the internship's goals. A model was constructed to represent these findings.DiscussionThe findings are important in identifying the inevitable barriers to virtual learning for health professions students and provide a better understanding of how such challenges and different experiences would be affecting the development of their PI. Hence, students, instructors, and policymakers alike should strive to minimize these barriers. Since physical interactions and patient contact are indispensable components of clinical teaching, these extraordinary times demand innovations involving technology and simulation-based teaching. There is a need for more studies that are focused on determining and measuring the short- and long-term effects of the VI on students' PI development.