bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dorsal Striatum in Obsessive-Compulsive Disorder: A Texture Analysis Study
Authors: Baykara Sema , BALCI Hale Nur , Kaşıkcı Halim Ömer , Baykara Murat 
Published: August 2023

Abstract
Aim: The aim of this study is to examine the MR images of the dorsal striatum, which is known to play a role in the etiopathogenesis in patients with obsessive-compulsive disorder (OCD), using texture analysis method.
Methods: Twenty-eight OCD patients with brain MRI images in the Hospital Picture Archiving and Communication System were included in the study. The control group were formed with 28 healthy individuals of the same age and gender as the study group. T1 weighted MRI images were obtained with 1.5T systems. All regions of the putamen, and caudate nucleus were selected individually in the axial images that best represent the anatomy, without exceeding their borders. Both symmetrical locations were used as separate samples (56 samples caudate 56 samples putamen for both groups).
Results: Most of the parameters for both locations showed statistically significant differences. ROC curve analysis showed high sensitivity and specificity for mean values for both nuclei. Logistic regressions for values to determine the effects of the calculated parameters of the nuclei on the probability of participants having OCD yielded important findings.
Conclusion: Tissue parameters in the dorsal striatum of OCD patients were found to be different from healthy controls. The study findings demonstrated that tissue analyzes are a useful technique for demonstrating tissue changes in the dorsal striatum using MR images of patients with OCD.
Sialyllactose Preserves Residual Hearing after Cochlear Implantation
Authors: Lee Min Young , Jung Seo-Kyung , Jang Jongmoon , Choi Hongsoo , Choung Yun-Hoon , Jang Jeong Hun 
Published: August 2023

Abstract

In individuals with hearing loss, protection of residual hearing is essential following cochlear implantation to facilitate acoustic and electric hearing. Hearing preservation requires delivery of the optimal quantity of a pharmacological agent using osmotic pumps. Several studies have reported variable hearing outcomes with osmotic pump-mediated steroid delivery. Several new drugs, including sialyllactose (SL), can prevent tissue overgrowth. In the present study, we used an animal model to simulate the damage due to electrode insertion during cochlear implantation. The positive effects of the pharmacological agent SL against insults were evaluated in vitro using HEI-OC1 cells. SL was delivered using osmotic pumps to prevent loss of the residual hearing in this animal model. We demonstrated hearing deterioration and tissue fibrosis and ossification in this model. Increased gene expressions of inflammatory cytokines were identified in the cochleae following dummy electrode insertion. Following the administration of SL, insertion led to a decrease in hearing threshold shifts, tissue reactions, and inflammatory markers. These results emphasize the possible role of SL in hearing preservation and improve our understanding of the mechanism underlying hearing loss after cochlear implantation.
Deep eutectic solvent-assisted fast and green synthesis of benzochromenopyrimidines and pyranopyrimidines
Authors: Monem Arezo , Habibi Davood , Goudarzi Hadis 
Published: August 2023

Abstract
A novel Deep Eutectic Solvent (MTPPBr/GA-DES) was prepared by a mixture of methyl triphenylphosphonium bromide (MTPPBr) and gentisic acid (GA: 2,5-dihydroxybenzoic acid). The eutectic point phase diagram showed that one mole of MTPPBr to one mole of GA is the best mole ratio for the synthesis of the new DES. Then, it was characterized by the FT-IR, NMR, densitometer, and TGA/DTA techniques and used as a capable and novel catalyst for the very fast and green synthesis of:
i) Five new 2(a-e) and five known benzo[6,7]chromeno[2,3-d]-pyrimidines 2(f-j) and
ii) Fourteen known pyrano[2,3-d]-pyrimidines 3(a-l), in solvent-free conditions, short reaction times and high yields.
Lessons Learnt in the First Year of an Australian Pediatric Cardio Oncology Clinic
Authors: Toro Claudia , Felmingham Ben , Jhadav Mangesh , Celermajer David S. , Gerche Andre La , O’Sullivan John , Kumar Sanjeev , Mateos Marion K. , Fulbright Joy , Govender Dinisha , Collier Lane , Cheung Michael , Eisenstat David , Lange Peter W. , Ayer Julian , Elliott David A. , Conyers Rachel 
Published: August 2023

Abstract
Background: Modern oncological therapies together with chemotherapy and radiotherapy have broadened the agents that can cause cardiac sequelae, which can manifest for pediatric oncology patients while on active treatment. Recommendations for high-risk patients who should be monitored in a pediatric cardio-oncology clinic have previously been developed by expert Delphi consensus by our group. In 2022 we opened our first multidisciplinary pediatric cardio-oncology clinic adhering to these recommendations in surveillance and management.
Objectives: Our pediatric cardio-oncology clinic aimed to:
(i) Document cardiovascular toxicities observed within a pediatric cardio-oncology clinic and
(ii) Evaluate the applicability of the Australian and New Zealand Pediatric Cardio-Oncology recommendations.
Methods: Monthly multidisciplinary cardio-oncology clinics were conducted in an Australian tertiary pediatric hospital. Structured standardised approaches to assessment were built into the electronic medical record (EMR). All patients underwent baseline echocardiogram and electrocardiogram assessment together with vital signs in conjunction with standard history and examination.
Results: Nineteen (54%) individuals had a documented cardiovascular toxicity or pre-existing risk factor prior to referral. The two most common cardiovascular toxicities documented during clinic review included Left Ventricular Dysfunction (LVD) and hypertension. Of note 3 (8.1%) patients had CTCAE grade III LVD. An additional 10 (27%) patients reviewed in clinic had CTCAE grade I hypertension. None of these patients had hypertension noted within their referral. Cascade testing for cardiac history was warranted in 2 (5.4%) of patients.
Conclusions: Pediatric cardio-oncology clinics are likely beneficial to documenting previously unrecognised cardiotoxicity and relevant cardiac family histories, whilst providing an opportunity to address lifestyle risk factors.
A biological cleaning agent for removing mold stains from paper artifacts
Authors: Meng Qingxia , Li Xianchao , Geng Junqiang , Liu Chenshu , Ben Songbin 
Published: August 2023

Abstract
Paper artifacts such as ancient books, documents and paper archives often suffer from microbial attack in the storage environment, forming mold stains on the paper surface, resulting in illegible content, and greatly reducing the artifact’s historical and artistic values. Therefore, efficient removal of mold stains becomes an important research topic for paper conservation. In this study, a cleaning scheme based on the combination of bioenzymes and biosurfactants was explored. Morphological and molecular biology identifications were first jointly applied to identify the dominant strains sampled from five ancient books that are stored in the same environment. Cellulolytic experiments were then conducted to evaluate the cellulose degradation ability of the strains according to the cellulolytic digestive index. Finally, paper Mockups for the ancient books were constructed to investigate the most effective combination of bioenzymes and biosurfactants in removing mold stains as well as its effect on the paper’s physical properties. The result concluded that the combination of 3% papain, 7% of sophorolipid or 7% of betaine, and distilled water, achieved optimal stain removal effect with over 50% cleaning rate at 35℃, after 30 minutes of infiltration. The maximum color difference of the paper material after cleaning was around 0.60, pH was between 7.45 to 7.79, and no significant changes in tensile strength were observed. At the same time, Sophorolipid and Betaine both have superior deacidification, anti-acidification, anti-aging, and reinforcement capabilities, which can provide extra support to the fibrous structure in addition to cleaning the paper materials. The microbial contamination cleaning agent proposed in this study shows promising application prospects in conserving mold-contaminated paper artifacts.
Optimizing Coverage and Deployment of Wireless Sensor Networks Based on Image Processing
Authors: Tossa Frantz , Ansari Keivan , Atchome Athanase 
Published: August 2023

Abstract
This paper proposes a novel approach for optimizing the coverage and deployment of Wireless Sensor Networks (WSNs) using image processing techniques. The proposed method involves the placement of an initial grid network on the map image, followed by the gradual decrease or increase of the radius of the initial operation and the adjustment of the placement of the nodes while also maintaining full connectivity communication between the sensors deployed. Our experiments demonstrate that this approach is effective in achieving the desired coverage and deployment of the wireless sensor network. It ensures efficient coverage and fully connectivity and can be applied to various application scenarios.
PRP significantly promoted the adhesion and migration of vascular smooth muscle cells on the stent material
Authors: Wu Yin-Di , Jiang Hong-Jing , Zhou Hao-Hao , Xu Jian-Yi , Liu Qing , Sun Xu-Heng , Wu Yue-Heng , Lin Zhan-Yi 
Published: August 2023

Abstract
Background The adhesion and survival state between cells and scaffold material is a major problem in the process of tissue engineered blood vessel (TEBV) culture. Platelet rich plasma (PRP) contains a large amount of biologically active factors and fibrin, which is expected to play an important role in the process of TEBV culture.Purpose To combine PRP with cells and scaffold material to promote cell adhesion and biological activity on the scaffold material.Methods The adhesion status and migration ability of SMC cells under the conditions of optimal concentration suitable for SMC growth and optimal concentration of PRP were examined by scanning electron microscopy, HE staining, CCK8, qPCR, WB and other experimental means, and compared with the situation of conventional culture (20% FBS); finally, the effect of PRP on the deposition of ECM in vascular tissue engineering culture was verified by three-dimensional culture.Results 20% PRP is a more suitable concentration of SMC, compared with the control group, the 20% PRP group has better migration ability, the number of SMC adhesion is significantly higher than the control group, in addition to this, the collagen deposition in the experimental group is significantly higher than the control experimental group.Conclusion 20% PRP can promote the ability of SMC adhesion, migration and collagen deposition on the scaffold material.
Functional connectivity patterns in parosmia
Authors: Thaploo Divesh , Joshi Akshita , Yilmaz Eren , Yildirim Duzgun , Altundag Aytug , Hummel Thomas 
Published: August 2023

Abstract
Objective
Parosmia is a qualitative olfactory dysfunction presenting as “distorted odor perception” in presence of an odor source. Aim of this study was to use resting state functional connectivity to gain more information on the alteration of olfactory processing at the level of the central nervous system level.
Methods
A cross sectional study was performed in 145 patients with parosmia (age range 20–76 years; 90 women). Presence and degree of parosmia was diagnosed on the basis of standardized questionnaires. Participants also received olfactory testing using the “Sniffin’ Sticks”. Then they underwent resting state scans using a 3T magnetic resonance imaging scanner while fixating on a cross.
Results
Whole brain analyses revealed reduced functional connectivity in salience as well as executive control networks. Region of interest-based analyses also supported reduced functional connectivity measures between primary and secondary olfactory eloquent areas (temporal pole, supramarginal gyrus and right orbitofrontal cortex; dorso-lateral pre-frontal cortex and the right piriform cortex).
Conclusions
Participants with parosmia exhibited a reduced information flow between memory, decision making centers, and primary and secondary olfactory areas.
Novel homozygous mutation in DYSF gene with limb-girdle muscular dystrophy type 2B through whole exome sequencing in Iran
Authors: Rastegar Mandana , Shadmehri Aazam Ahmadi , Firoozabadi Mohammad Dehghani , Sorosh Zahra , Dehghani Hossein , parsamanesh negin 
Published: August 2023

Abstract
Limb-girdle muscular dystrophy (LGMD) is a type of genetically heterogeneous disorders. The goal of current training is discovering novel mutations or deletion in an Iranian family with limb-girdle muscular dystrophy type 2B patient by whole exome sequencing. Exome sequencing was completed, as well as complete physical examinations of the family. Then, in silico studies have been done to discovery the change that happened in the protein structure, in associated with the DMD phenotype. On chromosome 2p13.2, there was one new nonsense variant: c.6120G>A, p.(Trp2040Ter) in exon 54. These discoveries can developed genetic counseling of this family and others patients in the future.
Evaluation of reference genes suitable for studying mRNAs and microRNAs expression in thyroid neoplasms
Authors: Jahanbani Iman , Al-Abdallah Abeer , Almoualem Nada 
Published: August 2023

Abstract
Analysis of gene expression is a pivotal method at the core of biomarkers studies and cancer research. Currently, RT-qPCR is the most commonly used technique to investigate the expression of certain genes. The accurate and reliable result relies on an effective normalization step using suitable reference genes. The present study was designed to evaluate the eligibility of a set of candidate mRNAs and snoRNA as reference genes in the most common human thyroid neoplasms. We tested the expression levels of eleven mRNA and small RNA housekeeping genes in thyroid samples. The stability of the candidate genes was examined in different thyroid lesions and under different experimental conditions. Results were compared to the reported data in the TCGA database. Our results suggested HPRT1 and ACTB as the best mRNA reference genes and SNORD96A and SNORD95 as the best miRNA reference genes in thyroid tissues. These genes showed the most stable expression pattern among different thyroid lesions as well as different experimental conditions. The findings in this study highlight the effect of reference genes selection on data interpretation and emphasize the importance of testing for suitable reference genes to be used in specific types of cells and experimental conditions to ensure the validity and accuracy of results.
Isolation, characterization, and genome analysis of two novel virulent bacteriophages infecting extensively drug-resistant (XDR) clinical Klebsiella pneumoniae in Bangladesh
Authors: Ananna Nishat Tasnim , Shishir Tushar Ahmed , Syed Muktadir Al Sium , Ahmed Akash , Shakil Md. Salman , Haque Fahim Kabir Monjurul , Hasanuzzaman Md. 
Published: August 2023

Abstract
Background- Klebsiella pneumoniae, an opportunistic and difficult-to-treat pathogen, is a leading cause of morbidity and mortality associated with multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections. This study evaluates the potential of bacteriophages as an alternative to antibiotics against XDR isolates of K. pneumoniae.
Methods- Thirty-one neonatal sepsis-causing Klebsiella spp. were collected, and K. pneumoniae were identified using both conventional and molecular techniques. Phenotypic and genotypic detection of ESBL (extended spectrum beta-lactamase) and carbapenem resistance was performed by disk diffusion and polymerase chain reaction (PCR). To isolate bacteriophages, sewage water samples were collected and enriched using reference host bacteria. Distinct morphological phage plaques were isolated by double layer agar assay (DLA). Characterization of bacteriophages was performed based on host range, temperature (4°C - 80°C upon 1 h incubation), pH (1-14 upon 1 h incubation), one-step growth curve, optimal multiplicity of infection (MOI), in vitro lytic ability and whole genome analysis.
Results- Two novel lytic bacteriophages, Klebsiella phage Kpn BM7 and Klebsiella phage Kpn BU9, were isolated and characterized based on their competency to kill more than one clinical strain of K. pneumoniae. Both phages can steadily survive until a temperature of 40°C and from pH 5 to pH 11 without any significant reduction. The optimal MOI was 0.1 and 1, with short latent times of 10 min and 25 min and burst sizes of 85 PFU/cell and 12 PFU/cell. Whole-genome analysis reported that phages BM7 and BU9 belong to class Caudoviricetes. BM7 was 170558 bp long, a member of the Marfavirus genus and Marfavirus F48 species, and phage BU9 was 60450 bp long, reported as unclassified. Both phages did not harbor any lysogenic, toxin, or antimicrobial resistance genes.
Conclusion- The isolated and established features of bacteriophages in this study can be a promising alternative solution to tackle XDR K. pneumoniae infection.
Thermodynamic evaluation of the surface tension and viscosity of liquid quaternary alloys: The Ti-Al-Cr-Nb system
Authors: Novakovic Rada , Giuranno Donatella , Mohr Markus , Fecht Hans-Joerg 
Published: August 2023

Abstract
Surface tension and viscosity of complex Ti-based industrial alloys are important for simulation of liquid assisted industrial processes such as casting, joining, crystal growth and infiltration. Modelling of the interface and mass transport during liquid-solid phase transition requires reliable surface tension and viscosity data. Therefore, to obtain accurate predictions of microstructural evolution during solidification related processes, only reliable input data are necessary. In the case of liquid Ti-Al alloys, the experimental difficulties related to high temperature measurements and reactivity of these alloys with supporting materials or containers as well as inevitable presence of oxygen may lead to data gaps including a complete lack of property data. An alternative for container-based methods are containerless processing techniques that offer a significant accuracy improvement and / or make possible to measure temperature and composition dependent thermophysical properties of metallic melts, as in the case of the Ti-Al-Cr-Nb system. Advanced mathematical models and computer simulations, developed in several theoretical frameworks, can be used to compensate the missing data; on the other side, for the validation of theoretical models, the experimental data are used. In the present work, an evaluation of the surface tension and viscosity of liquid Ti-Al-Cr-Nb alloys by means of the predictive models and a comparison to the available experimental data were done. The proposed methodology is a tool to assess the reliability of thermophysical properties data of multicomponent alloy systems.
Study synthetic method, photoluminescence mechanism and optimistic applications of KAlSiO 4 Phosphor
Authors: Bhelave Samirkumar R. , Yerpude A. N. 
Published: August 2023

Abstract
KAlSiO4:Eu3+, Tb3+ phosphor synthesized first time by simple combustion method. The X-ray diffraction (XRD) study confirms that the KAlSiO4 phosphor matrix successfully matches to standard JCPDS database file. Photoluminescence properties observed for rare earth Eu3+, Tb3+ at various concentration (x = 0.3, 0.5, 1.0, 1.3 mole %) shows an optimistic luminescence property. KAlSiO4 matrix shows unique emissions of Eu2+ and Eu3+ ions when excited by 395 nm, where the utmost emission intensity was received when x = 1.0 mole%. The excitation spectra of KAlSiO4:Eu3+ give proper peak position at 262 nm, 395 nm, and 465 nm corresponding to O2+→ Eu3+, 7F0 →5L6, 7F0 → 5D2. While sharp emissions peaked at 593 nm and 613 nm are obtained by 7F0 → 5D1 and 7F0 → 5D2 transitions. On the other hand, KAlSiO4:Tb3+ shows the excitation peak position at 352 nm,370 nm, and 378 nm which gives the sharp green emission peak at 545 nm due to the 5D4 →5F5 transitions. The particle size and elemental constitution determine using SEM-EDX analysis which is in the range of micrometers in size. The band gap and refractive index are determined using UV-visible spectroscopy. CIE chromaticity coordinate shows multicolor emission for KAlSiO4:Eu3+ while the green color emission for the KAlSiO4:Tb3+ phosphor. Photoluminescence (Pl) spectroscopy reveals the exciting luminescent properties of the KAlSiO4:Eu3+, Tb3+ phosphor which may be applicable potential phosphor for fabrication of various light emitting devices.
Effect of vegetation degradation on the soil quality of green spaces in a tropical megacity (Lubumbashi, DR Congo): potential implications for ecosystem services
Authors: Mashagiro Grace Queen , Mujinya Bazirake Basile , Colinet Gilles , Mahy Grégory 
Published: August 2023

Abstract
Urban soils are degraded by a range of human pressures, including vegetation degradation, leading to modifications of physical and chemical characteristics, and affecting important ecosystem services. We assessed the impact of vegetation degradation in six urban green spaces (bare soils versus vegetated soils) on the physical (texture, soil bulk density and structure) and chemical (pH, CEC, OC, N, P, K, Cu and Mn) qualities of soils in a tropical megacity (Lubumbashi, DR Congo). Vegetated soils presented better physical and chemical qualities than bare soils. Vegetated soils were characterized by a high clay and silt content and a good consistency (structure), while bare soils were characterized by a high sand content and high bulk density. Vegetated soils were characterized by higher pH, OC, N, C/N, OM, CEC, P, and K. There was no significant difference in Mn or Cu between bare and vegetated soils. Cu was highly variable between sites (from 99±61 mg.kg-1 in VS-CHL to 8559±151 mg.kg-1 in BS-ZOO). Our results demonstrate that the destruction of vegetation, leading to bare soil, negatively affects soil properties and may interfere with ecosystem services provided by urban soils in tropical climates.
MuMUR : Multilingual Multimodal Universal Retrieval
Authors: Madasu Avinash , Aflalo Estelle , Stan Gabriela Ben Melech , Rosenman Shachar , Tseng Shao-Yen , Bertasius Gedas , Lal Vasudev 
Published: August 2023

Abstract
Multi-modal retrieval has seen tremendous progress with the development of vision-language models. However, further improving these models require additional labelled data which is a huge manual effort. In this paper, we propose a framework MuMUR, that utilizes knowledge transfer from a multilingual model to boost the performance of multi-modal (image and video) retrieval. We first use state-of-the-art machine translation models to construct pseudo ground-truth multilingual visual-text pairs. We then use this data to learn a joint vision-text representation where English and non-English text queries are represented in a common embedding space based on pretrained multilingual models. We evaluate our proposed approach on a diverse set of retrieval datasets: five video retrieval datasets such as MSRVTT, MSVD, DiDeMo, Charades and MSRVTT multilingual, two image retrieval datasets such as Flickr30k and Multi30k . Experimental results demonstrate that our approach achieves state-of-the-art results on all video retrieval datasets outperforming previous models. Additionally, our framework MuMUR significantly beats other multilingual video retrieval dataset. We also observe that MuMUR exhibits strong performance on image retrieval. This demonstrates the universal ability of MuMUR to perform retrieval across all visual inputs (image and video) and text inputs (monolingual and multilingual).