bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity
Authors: Liu Jia , W. Aylor Kevin , Liu Zhenqi 
Published: April 2023

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<p>Inflammation-induced vascular insulin resistance is an early event in diet-induced obesity and contributes to metabolic insulin resistance. To examine whether exercise and glucagon-like peptide 1 (GLP-1) receptor agonism, alone or in combination, modulate vascular and metabolic insulin actions during obesity development, we performed a euglycemic insulin clamp in adult male rats after 2 weeks of high-fat diet feeding with either access to running wheel (exercise), liraglutide, or both. Rats exhibited increased visceral adiposity and blunted microvascular and metabolic insulin responses. Exercise and liraglutide alone each improved muscle insulin sensitivity but their combination fully restored insulin-mediated glucose infusion rates. The combined exercise and liraglutide intervention enhanced insulin-mediated muscle microvascular perfusion, reduced perivascular macrophage accumulation and superoxide production in the muscle, attenuated blood vessel inflammation and improved endothelial function, along with increased endothelial nucleus translocation of NRF2 and increased endothelial AMPK phosphorylation. We conclude that exercise and liraglutide synergistically enhance the metabolic actions of insulin and reduce vascular oxidative stress and inflammation in the early stage of obesity development. Our data suggest that early combination use of exercise and GLP-1 receptor agonism might be an effective strategy in preventing vascular and metabolic insulin resistance and associated complications during the development of obesity.</p>
Experimental Validation of Elliptical Contact Patch Tire Model
Authors: Nakanishi Ryota , Matsubara Masami , Ishibashi Takashi , Kawamura Shozo , Tajiri Daiki 
Published: April 2023

ABSTRACT
The influence of tires on vehicle dynamics, as the only automotive component in contact with the road surface, is significant. Mechanical models such as the Fiala model includes tire mechanical properties as parameters and are useful for tire design studies. These models assume a rectangular or trapezoidal tire contact shape, which does not always match the tire contact shape observed when slip angle is applied, leaving room for improvement in accuracy. This study proposes a new semiphysical tire model with an elliptical contact shape, termed the “elliptical contact model.” First, the expressions for the contact shape and contact pressure distributions in the elliptical contact model are formulated. Herein, we consider both the length- and width-direction distributions of the contact pressure in these expressions. Second, the formulation of the lateral shear stress distribution in the contact patch is presented based on the Fiala model, including the belt bending deformation by a lateral force and switching between the lateral shear and dynamic frictional forces. Lateral stresses proportional to the width coordinate are also introduced, enabling the calculation of lateral stresses acting in a direction counteracting each other at the widthwise edge of the tire contact surface. The model is validated by measuring a slick tire at a velocity of 100 km/h with slip angles of 0° and 3° using an Inside Drum Machine with an aluminum road segment with quartz piezoelectric sensors. Consequently, by setting appropriate model parameters, the contact pressure and lateral shear stress distribution results calculated using the model are consistent with experimental results. The accuracy of the proposed model could be further improved by revising the method of setting the static and dynamic friction coefficients.
Pemanfaatan Biji Lamtoro untuk Pembuatan Kecap dan Pemberdayaan Kelompok PKK di Desa Kaliploso Cluring, Banyuwangi
Authors: Rachmah Alif Nur Laili , Susanti Yuni , A’yun Ayu Qurota , Ansori Ansori , Sekaringgalih Ratri 
Published: April 2023

The community service program carried out in Kaliploso Village, Cluring District, Banyuwangi Regency is a sharing of knowledge from chemical engineering lecturers and students to the community. The aim of implementing this program is to increase the creativity of the Kaliploso community by using lamtoro seeds as an alternative to soybeans as the basic ingredient for making soy sauce with the addition of special spices. The program implementation method begins with outreach, training in making soy sauce, fostering independent production, to monitoring, and evaluation. First, socialization to the community regarding the natural potential in Kaliploso village, especially on the nutritional content of lamtoro seeds, secondly, training on making lamtoro soy sauce is explained in detail regarding the composition, tools used, and the stages of the soy sauce making process, thirdly, assistance and encouragement for independent production to participants who have formed 4 groups to make lamtoro soy sauce at home, the last stage is monitoring and evaluation carried out to measure the level of success of the program for utilizing the natural potential and community empowerment through training in making lamtoro soy sauce. The impact of the program that has been carried out can ignite the community to be more productive, create products that can add economic value and promote prosperity in Kaliploso village, and the soy sauce product "Cap Roso" which is produced as a product the hallmark of Kaliploso village for more known by outsiders.
Seed invigoration using ultrafine bubble water to increase the vigor of true shallot seed (Allium ascalonicum L.)
Authors: Raga Yuan , Widajati Eny , Purwanto Yohanes Aris 
Published: April 2023

True shallot seeds are preferable to tubers as planting materials because of their advantages in storage longevity, lower management cost, and lower seed-borne disease risk. However, environmentally limited production and seed deterioration in uncontrolled storage have limited its application. Pre-sowing hydration invigoration accelerates and synchronizes the germination of deteriorated seeds. Ultra-fine bubble water (UFBW) contains reactive oxygen species, which can advance the pre-germinative metabolism of the seed. This study examined true shallot seed invigoration using UFBW. The experiment was conducted in a two-factor of randomized complete block design. The first factor was initial seed vigor based on the vigor index with six levels, i.e., 24, 15, 13, 12, 10, and 9%. The second factor was the invigoration treatment of UFBW (8 and 23 ppm dissolved oxygen concentrations) with two durations (24 and 48 h), 50 ppm GA3, and 3% KNO3 (24 h). UFBW with 23 ppm invigoration for 48 h improved seed vigor based on all vigor parameters. The GA3 50 ppm treatment is the most effective in increasing seed vigor.
Keywords: dissolved oxygen; pre-sowing hydration; reactive oxygen species; seed viability; seed vigor
Growth, yield, and land use efficiency of soybean-maize relay cropping under saturated soil culture on tidal swamps
Authors: Sahuri  , Munif Ghulamahdi  , Suwarto  
Published: April 2023

More than 75 percent of households growing maize and soybean adopts the monoculture method. The relay cropping of soybean-maize is a strategic choice to increase the planted area and productivity of these two commodities' sustainability in tidal swamps. The research aimed to study the land equivalent ratio (LER), determine the best planting spacing and soybean varieties, and the best relay cropping of maize on saturated soil culture in tidal swamps. The experiment was on mineral soils with type B tidal swamps, in Banyuasin, South Sumatra, from July to December 2022. The experiment used a three-factor randomized complete block design with three replications. The first factor was soybean varieties: Argomulyo, Gepak Kuning, Detap 1, and Demas 1, the second factor was soybean planting spacing: 78 cm x 15 cm x 12.5 cm and 60 cm x 40 cm x 10 cm, and the third factor was the relay cropping of maize: 30 and 45 days after planting (DAP) of soybeans. Results showed that plant height, number of leaves, number of branches, filled pods, 100 seeds weight, and seed yield were influenced significantly by varieties. Demas 1 variety produced a higher seed yield, with relay cropping and monoculture, i.e., 4.2 tons ha-1 and 4.1 tons ha-1, respectively. Plant height, stem diameters, number of leaves, 100 grains weight, and grain yield in maize were significantly higher at soybean planting spacing of 78 cm x 15 cm x 12.5 cm and relay cropping at 30 DAP. The LER values > 1, indicated that relay cropping increased land productivity as compared to monoculture cultivation. The LER at relay cropping of 30 DAP was significantly highest for Argomulyo and Detap 1 varieties, i.e., 1.8 and 1.8, respectively.
Keywords: Land equivalent ratio, planting spacing, relay cropping, saturated soil culture, tidal swamps
Evaluation of a correlation between the severity of root resorption of adjacent teeth and level of difficulty of impacted canine – A cone-beam computed tomography study
Authors: Chhutani Priyanka Dinesh , Deshmukh Sonali Vijay , Khan Adnan Sarfaraz , Rahalkar Jayesh S. 
Published: April 2023

Objectives:
An interrelation between the level of difficulty of canine impaction based on its three-dimensional position and the degree of root resorption of the adjacent teeth improves the quality of orthodontic treatment planning. It would be advantageous for clinicians to know the predilection of resorption in varying canine positions. The aim of the study is to evaluate and correlate the severity of root resorption of adjacent teeth and the level of difficulty of impacted canine classified by KPG Index and sector analysis using cone-beam computed tomography.

Material and Methods:
The study sample comprised 48 impacted canines in orthodontic patients (17 boys and 27 girls) with a mean age of 24 years. The cone-beam computed tomographs were evaluated using Dolphin Imaging Software and primarily, three observations were recorded: KPG index, sector analysis, and root resorption. The samples were equally divided into four groups based on the KPG index, with 12 samples in each group. Additionally, the inclination of the canine in the frontal plane and their degree of vertical eruption were recorded.

Results:
The number and severity of resorptive lesions increased as the KPG score escalated. The mean KPG score was 13.67 ± 6.336 and the average KPG index was 2.5 ± 1.13. A statistically significant positive correlation was found between all the parameters and root resorption.

Conclusion:
A positive correlation exists between the level of difficulty of canine impaction and root resorption of the adjacent teeth. A KPG score higher than 13.67 can be a resourceful predictor of resorptive lesions. An increased tendency of root resorption of the neighboring teeth was observed when angle α and angle β exceed 43.71° and 43.26°, respectively.
ИСПОЛЬЗОВАНИЕ БИОАКТИВНЫХ ПЕПТИДОВ ДЛЯ ОБЕСПЕЧЕНИЯ КАЧЕСТВА И ХРАНИМОСПОСОБНОСТИ ХЛЕБА
Authors: Резниченко Ирина Юрьевна , Акопян Гиоргий Сергеевич 
Published: April 2023

Разработка и внедрение в практику инновационных технологий, оценка влияния новых биологически активных веществ в форме биопептидов на качество продуктов питания является актуальным направлением исследований. Отдельное направление исследований связано с использованием пептидов в качестве природных консервантов, т.к. порча и загрязнение пищевых продуктов, зачастую связанные с микроорганизмами, особенно бактериями и грибками, приводят к потерям продуктов питания и серьезным заболеваниям пищевого происхождения. Пептиды обладают высокой биологической активностью, характеризуются антимикробными, бактерицидными, противовирусными свойствами в наноконцентрациях, что определило их перспективность использования в технологиях пищевых продуктов. Цель работы заключалась в обосновании применения БАД (ферментативный гидролизатфабрициевой сумки цыплят бройлеров) в технологии производства хлеба пшеничного для увеличения срока хранения и улучшения качественных характеристик хлеба.Объектами исследования являлись модельные образцы хлеба пшеничного из муки высшего сорта с добавлением БАД. В качестве методов исследования применяли методы анализа, систематизации, обобщения информационных данных поисковых отечественных и международных систем за последние пять лет, стандартные и отраслевые методы контроля сырья и изделий хлебопекарного производства. Установлено, что величина упека хлеба достоверно снижается с увеличением дозировки БАД, влажность мякиша хлеба незначительно увеличивается (на 4%), что подтверждает данные о гидрофильности вносимых пептидов, кислотность хлеба увеличивается с увеличением дозировки гидролизата. Пористость мякиша и удельный объем хлеба с увеличением дозировки гидролизата увеличились на 7% и 31 % соответственно.Оценка показателей безопасности выявила, что хлеб с 50% заменой раствора соли на БАД в течение 120 часов сохранял свои первоначальные свойства, хлеб с полной заменой – 168 часов, контроль – 72 часа. Установлен рекомендуемый срок хранения хлеба с полной заменой солевого раствора БАД 144 часа(6 суток).Исключение соли из рецептуры при внесении 100% БАД позволяет отнести разработанный хлеб к ахлоридному, т.е. хлебу специализированного назначения. Из результатов исследований следует, что ферментативные гидролизаты белка фабрициевой сумки, содержащие антимикробные пептиды, являются многообещающими альтернативами для использования в качестве натуральных консервантов, но также необходимы новые исследования для подтверждения полученных данных и оценки других показателейкачества и отсутствия аллергенности хлеба.
Peran Orang Tua dalam Mengurangi Dampak Negatif Gadget Pada Anak
Authors: Febriani Indah , Sumardi Lalu , Hadisaputra Saprizal , Muhaimi Lalu 
Published: April 2023

Gadget merupakan sesuatu yang bisa dibilang saat ini sudah tidak bisa lagi dipisahkan dari kehidupan manusia, bahkan perkembangan gadget sudah tidak lagi memandang usia baik usia anak-anak, remaja, dewasa, sampai orang tua sekalipun semua sudah dipengaruhi oleh gadget. Penelitian ini memiliki bertujuan untuk mendeskripsikan peran orang tua dalam mengurangi dampak gadget terutama pada hasil belajar anak usia dibawah 10 tahun. Penelitian ini termasuk ke dalam penelitian kualitatif dengan jenis studi kasus. Sumber data dari penelitian ini yaitu orang tua dan anak usia dibawah 10 tahun. Metode pengumpulan data yang digunakan di dalam penelitian ini menggunakan metode observasi (pengamatan) dan wawancara. Teknik analisis data yang digunakan adalah teknik analisis data model interaktif yang dikembangkan Miles, Huberman, dan Saldana yang mencakup tiga tahapan yaitu; kondensasi data, penyajian data, dan penarikan kesimpulan. Hasil dari penelitian ini yaitu dapat diketahui bahwa terdapat 5 upaya orang tua dalam mengurangi dampak gadget pada anak usia dibawah 10 tahun yaitu; (1) Mengajarkan anak untuk memperhatikan waktu dalam menggunakan gadget dengan membuat aturan waktu atau jadwal dalam menggunakan gadget; (2) menyediakan berbagai jenis permainan di dalam gadget yang bisa digunakan sebagai sarana pembelajaran bagi anak; (3) orang tua memberikan kesempatan kepada anak untuk bercerita mengenai hal apa saja yang telah dilakukan; (4) orang tua memberikan kesempatan anak untuk mencoba permainan tradisional dengan teman sebayanya di lingkungan sekitar; (5) orang tua tidak menggunakan gadget ketika sang anak berada di sampingnya dan menggunakan gadget seperlunya saja. Berdasarkan temuan tersebut maka bisa disimpulkan bahwa peran keluarga terutama seorang orang tua sangatlah penting dalam mengatasi dan mencegah dampak negatif penggunaan gadget pada anak karena keluarga merupakan sekolah dan tempat belajar pertama bagi seorang anak.
ALIRAN KALAM SALAFIYAH: Studi atas Perkembangan Pemikirannya
Authors: Miolo Darwin Agung Septian , Arif Muhammad 
Published: April 2023

Artikel ini bertujuan untuk mengungkap bagaimana aliran kalam salafiyah dan bagaimana perkembangan pemikirannya. Metode yang digunakan adalah metode analisis kualitatif deskriptif. Hasil kajian dan pembahasan menunjukkan bahwa aliran kalam salafiyah mempunyai beberapa karakteristik sebagaimana dikemukakan oleh Ibrahim Madzkur yaitu: pertama, mereka lebih mendahulukan riwayat (naqli) dari pada dirayah (aqli); kedua, dalam persoalan pokok-pokok agama dan persoalan cabang-cabang agama hanya bertolak dari penjelasan al-Kitab dan as-Sunnah; ketiga, mereka mengimani Allah tanpa perenungan lebih lanjut (Dzat Allah) dan tidak mempunyai paham anthromophisme (menyerupakan Allah dengan makhluk); keempat, mengartikan ayat-ayat al-Qur’an sesuai dengan makna lahirnya dan tidak berupaya untuk mentakwilnya. Ibn Taimiyah mengemukakan bahwa kaum salaf adalah mereka mempunyai pemikiran bahwa tidak ada jalan untuk mengetahui akidah, hukum, dan apa yang keduanya ada hubungan dengannya, tidak lain hanya berpedoman pada al-Qur’an dan Hadis. Kaum Salaf menerima semua keterangan yang ada dalam al-Qur’an dan Hadis. Menolak berarti melepas tali agama. Akal tidak mempunyai kekuasaan untuk mentakwilkan, menafsirkan, atau menghukumi al-Qur’an. Akal hanya mampu membenarkan, mentaati, dan menerangkan pendekatan antara dalil akal (kontekstual), dengan dalil al-Qur’an dan Hadis (tekstual) dengan tidak ada perbedaan antara dalil akal dengan dalil al-Qur’an dan Hadis. Akal berkedudukan sebagai saksi bukan hakim, sebagai penetap dan penguat bukan penentang, sebagai penjelas dari dalil yang terkandung dalam al-Qur’an. Kaum Salaf selalu menjadikan akal berada di belakang al-Qur’an dan Hadis.
Kebebasan Manusia Khudi (Ego/Diri) Muhammad Iqbal dalam Perspektif Kebebasan Whitehead
Authors: Wibawa Nazar Husain Hadi Pranata 
Published: April 2023

Artikel ini membahas tentang kebebasan manusia. Artikel ini ingin menemukan kebebasan manusia menurut Muhamaad Iqbal sebagai objek material dan Whitehead sebagai objek formal. Penelitian ini merupakan studi pustaka. Data dikumpulkan melalui inventarisasi data, kemudian dianalisis dan diinterpretasikan. Hasil penelitian menunjukkan Diri bersifat individual, namun ke-individualitas-an diri/ego tidak berarti menjadikannya egoistik dan terisolir. Setiap ego bersama dengan ego-ego lainnya terikat dalam relasi simbiosis mutualistik, karena ego hidup dalam jejaring organisasional, dan ego sendiri pada level kediriannya bersifat holistik. Setiap keegoan pribadi dapat diakses oleh ego ego yang lain dengan istilah simbiosis mualistik. Kehendak pribadi terbuka dengan ego atau kehendak orang lain untuk mencipkan masyarakat yang terbuka. Whitehead memperinci kehendak itu tidak sama dengan tindakan praktis, karena kehendak mempunyai superiotitas sendiri dan sebaliknya kehendak tidak dapat disamakan pengetahuan teoritis, karena kita bias melihat gejala-gelaja tegangan yang sering muncul dan sulit didamaikan antara keduanya. Kehendak harus diletakkan pada tindakan praktis dan pengetahuan teoritis.
Relationship Between Internet Scrolling Habit and Social Media Marketing
Authors: Piya Sujayana , Adhikari Basanta Pd 
Published: April 2023

The previous study has concluded that internet scrolling is required to generate business, and social media employs psychological techniques to advertise for business purposes. The primary objective of this study was to investigate the opinions and experiences of bachelor’s level students on the role of internet scrolling addiction impact on social media marketing. This study applied the quantitative approach and the survey instrument to collect data. The sample population was two hundred bachelor’s level students at Oxford College of Engineering and Management. A random sampling method was used to select sample students among three thousand students
The results show a significant association between internet scrolling habits and observing social media marketing, implying a negative association with using social media marketing (p < 0.05). Similarly, there was a positive association between social media marketing and influence on chatting apps (p < 0.05). Further, the results indicated a negative association between time of activeness and the use of social media with social media marketing. This study's implication would benefit social media marketers, students, scholars, entrepreneurs and owners of social media marketing businesses.
Correlation between Initial International Prostate Symptom Score (IPSS) and Complications of Benign Prostatic Hyperplasia
Authors: Chamnarnprai Santapon , Laowanichwith Keerati , Sinsophonphap Akachai , Chuntanaparb Nol , Boonyapalanant Chatporn 
Published: April 2023

Objective: Benign prostatic hyperplasia (BPH) is a common disease in elderly men, and some of them are suffering from its complications. Early detection and management of complications of BPH will lead to optimal results of treatment. The International Prostate Symptom Score (IPSS) is a disease and symptom-specific scoring system used for initial evaluations of BPH patients. This study aims to determine the correlation between initial IPSS and complications resulting from BPH. Material and Methods: This hospital-based cross-sectional study enrolled all male patients, aged 60 years and above having complained of lower urinary tract symptoms (LUTS), at the outpatient clinic. Patients’ demographic data (age), IPSS, and history of complications from BPH; including urinary tract infection (UTI), hematuria, urinary retention and prostate related surgery were collected. Results: In total, 301 patients were recruited in this study, with a mean age of 70.1 years old. There was significant correlation between age and IPSS (p-value 0.034), by using correlation coefficients. Sub-group analysis demonstrates a significant correlation of IPSS (both mean and severity group classifications) and complications from BPH (UTI, hematuria, urinary retention, and prostate surgery due to BPH) (p-value<0.001). Conclusion: The rate of complications, due to BPH including UTI, hematuria, urinary retention, and BPH-related surgery, correlate with higher initial IPSS.
Ways to Evaluate Alkali-Silica Reactivity of Mineral Fillers
Authors: Sinno Noura , Shehata Medhat 
Published: April 2023

<p>Mineral fillers used to attain specific properties in concrete might have the potential for alkali-silica reaction. This study investigates the potential reactivity of fillers using two standard test methods: 1) the Accelerated Mortar Bar Test (AMBT), and 2) the Concrete Prism Test (CPT). </p>
<p>Proceeding of the 16th International Conference on Alkali-Silica Reaction, Lisbon, Portugal, Proceedings # 1, Paper # 35</p>
THE INFLUENCE OF EDUCATIONAL VIDEOS ON SEXUAL VIOLENCE KNOWLEDGE IN BENGKULU PUBLIC ELEMENTARY SCHOOLS IN BENGKULU CITY 2021
Authors: Mardiani Mardiani , Hermansyah Hermansyah , Husni Husni 
Published: April 2023

Cases of sexual violence are ranked first in cases of violence against children. The Indonesian Child Protection Commission (KPAI) stated that from 2011-2016 there were 1,875 cases of sexual violence in early childhood. This study aimed to determine the effect of educational videos on the knowledge of elementary school children about sexual violence in the State of Bengkulu City in 2021.This research is quasi-experimental. The sample size of 60 students for each of the 30 intervention groups and 30 control groups. Analysis using Mann Whitney. The results showed that the average knowledge before intervention in the intervention group was 9.70 and in the control group was 10.73. The average knowledge after intervention in the intervention group was 13.93 and in the control group was 10.80. The analysis showed a significant difference in increasing the average value about maturation after marriage knowledge between groups before and after the intervention with a p value of 0.000. Thus, it is necessary to develop learning and educational methods, to increase health promotion activities, to increase the knowledge of elementary school children about sexual violence