bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Generation Stellar Spectral Libraries in the Optical and Near-infrared. I. The Recalibrated UVES-POP Library for Stellar Population Synthesis*
Authors: Borisov Sviatoslav B. , Chilingarian Igor V. , Rubtsov Evgenii V. , Ledoux Cédric , Melo Claudio , Grishin Kirill A. , Katkov Ivan Yu. , Goradzhanov Vladimir S. , Afanasiev Anton V. , Kasparova Anastasia V. , Saburova Anna S. 
Published: May 2023

Abstract
We present reprocessed flux-calibrated spectra of 406 stars from the UVES-POP stellar library in the wavelength range 320–1025 nm, which can be used for stellar population synthesis. The spectra are provided in the two versions having spectral resolving power R = 20,000 and R = 80,000. Raw spectra from the ESO data archive were re-reduced using the latest version of the UVES data reduction pipeline with some additional algorithms that we developed. The most significant improvements in comparison with the original UVES-POP release are (i) an updated echelle order merging, which eliminates “ripples” present in the published spectra; (ii) a full telluric correction; (iii) merging of nonoverlapping UVES spectral setups taking into account the global continuum shape; (iv) a spectrophotometric correction and absolute flux calibration; and (v) estimates of the interstellar extinction. For 364 stars from our sample, we computed atmospheric parameters T
eff, surface gravity log g, metallicity [Fe/H], and α-element enhancement [α/Fe] by using a full-spectrum fitting technique based on a grid of synthetic stellar atmospheres and a novel minimization algorithm. We also provide projected rotational velocity

v
sin
i

and radial velocity v
rad estimates. The overall absolute flux uncertainty in the reprocessed data set is better than 2%, with subpercent accuracy for about half of the stars. A comparison of the recalibrated UVES-POP spectra with other spectral libraries shows a very good agreement in flux; at the same time, Gaia DR3 BP/RP spectra are often discrepant with our data, which we attribute to spectrophotometric calibration issues in Gaia DR3.
Solar System-scale Interferometry on Fast Radio Bursts Could Measure Cosmic Distances with Subpercent Precision
Authors: Boone Kyle , McQuinn Matthew 
Published: May 2023

Abstract
The light from an extragalactic source at a distance d will arrive at detectors separated by 100 au at times that differ by as much as 120(d/100 Mpc)−1 nanoseconds because of the curvature of the wave front. At gigahertz frequencies, the arrival time difference of a point source can be determined to better than a nanosecond with interferometry. If the spacetime positions of the detectors are known to a few centimeters, comparable to the accuracy to which very long baseline interferometry baselines and global navigation satellite systems (GNSS) geolocations are constrained, nanosecond timing would allow competitive cosmological constraints. We show that a four-detector constellation at Solar radii of ≳10 au could measure geometric distances to individual sources with subpercent precision. The precision increases quadratically with baseline length. Fast radio bursts (FRBs) are the only known bright extragalactic radio source that are sufficiently point-like for this experiment, and the simplest approach would target the population of repeating FRBs. Galactic scattering limits the timing precision at ≲3 GHz, whereas at higher frequencies the precision is set by removing the differential dispersion between the detectors. Furthermore, for baselines greater than 100 au, Shapiro time delays limit the precision, but their effect can be cleaned at the cost of two additional detectors. Outer solar system accelerations that result in ∼1 cm uncertainty in detector positions could be corrected for with weekly GNSS-like trilaterations between members of the constellation. The proposed interferometer would not only provide a geometric constraint on the Hubble constant, but also could advance solar system, pulsar, and gravitational wave science.
Molecular and Immunohistochemical assessment of Fibroblast Growth Factor Receptor 3 (FGFR3) gene as a survival time predictor in bladder cancer patients
Authors: Mamdouh Samah , Aboushousha Tarek , Hammam Olfat , Khorshed Fatma , Safwat Gehan , Elesaily Khaled 
Published: May 2023

BACKGROUND: Mutation signatures contributing to the tumorigenesis of bladder cancer (BC) are complex and heterogeneous, resulting in unpredictable progression, recurrence, and time survival. Clinically, useful prognostic and predictive biomarkers for both disease recurrence and surveillance are therefore needed. Activating fibroblast growth factor receptor 3 (FGFR3) mutations are regarded as early drivers in the molecular pathogenesis of BC.
AIM: The aim of the present study is to evaluate the frequency and distribution pattern of FGFR3 mutation in urine sediments of BC patients in relation to its immunohistochemical (IHC) and molecular expression and to determine the prognostic and predictive value of FGFR3 relative to BC.
PATIENTS AND METHODS: One hundred and sixty patients with diagnosed BC and 80 healthy controls were recruited. Urine samples were collected from all participants. DNA was extracted and FGFR3 mutations were examined in exons 7, 10, and 15 by polymerase chain reaction. IHC for FGFR3 expression and fluorescence in situ hybridization technique for assessment of gene amplification was also applied in tissue sections.
RESULTS: Ninety-eight (61.3%) patients were mutant in exon 7, 82 (51.3%) were mutant in exon 10, while only 14 (8.8%) were mutant in exon 15. Univariate logistic regression analysis revealed that mutations in the three exons of FGFR3 were statistically associated with BC and could be used as predictor and/or prognostic parameters for BC. Receiver operating characteristic analysis showed that the mutation of exons 7 and 10 could be used as diagnostic biomarkers for BC. Our findings confirm that FGFR3 mutations are associated with tumors of low grade and stage. The prevalence of mutations was significantly associated with recurrence and survival time of patients for all exons. Kaplan–Meier analysis revealed a significant association between mutant patients in exon 10 and survival time. Our findings suggest that estimation of FGFR3 expression and gene amplification could serve as a prognostic indicator in the follow-up of BC patients. It could also be utilized for molecular targeted therapy in BC.
CONCLUSION: Our data confirmed the feasibility of FGFR3 mutation detection in urine sediment. FGFR3 genetic mutations are independent prognostic factors for tumor recurrence and the genetic alternation of FGFR3 could be used for prediction of survival time of BC patients.
The snakeflies of the Mediterranean islands: review and biogeographical analysis (Neuropterida, Raphidioptera)
Authors: Aspöck Horst , Aspöck Ulrike 
Published: May 2023

The Mediterranean region representsone of the hotspots of biodiversity of many organisms and among these also of Raphidioptera. With about 250 known species world-wide Raphidioptera is the smallest order of extant holometabolous insects.The Mediterranean region harbors 113 species (= &gt;45% of the world fauna), and of these 33 (= &gt;13% of the world fauna) have been found on islands of the Mediterranean Sea. In the course of the past 50 years most of the larger islands have been intensively explored for Raphidioptera, particularly all islands (except the Baleares) which had no connection to the mainland throughout the whole Pleistocene. Altogether, 11 species of Raphidioptera (9 Raphidiidae, 2 Inocelliidae) are endemic to (usually)one, rarely to a few Mediterranean islands:Phaeostigma (Ph.) euboica (Euboea), Ph. (Aegeoraphidia) prophetica (Rhodes), Ph. (Ae.) karpathana (Karpathos), Ph. (Ae.) biroi (Crete), Ph. (Superboraphidia) minois (Crete),Subilla principiae(Sardinia),S. colossea(Rhodes), Raphidia (R.) peterressli (Chios), R. (R.) ariadne (Crete), Fibla (F.) maclachlani (Corsica, Sardinia, Sicily), F. (Reisserella) pasiphae (Crete).In the Aegean Sea there is a remarkable difference between the eastern and the western islands marked by the so-called Rechinger line based on results of the analysis of the flora. The Raphidioptera confirm this line impressively.It is rather unlikely that further Raphidioptera species endemic to Mediterranean islands are still to be detected – with one exception: the Baleares. A few additional species known from various parts of the continents surrounding the Mediterranean Sea will probably be found on islands so that a total number may be around 40, possibly around 45 species.The possible ways and times of colonization of the islands by Raphidioptera are discussed. The present paper may serve as a basis for studies on natural and particularly on anthropogenic dispersals of snakeflies from island to island, from mainland to islands, and from islands to the mainland in connection with phylogeographic investigations.
Les ralliements dans les Forces Aériennes Françaises Libres (juin 1940 – juillet 1943) : construire une force aérienne
Authors: Le Bras Bertrand 
Published: May 2023

Composante importante de la France libre, les Forces Aériennes Françaises Libres (FAFL) durent être formées de toutes pièces à partir de l’été 1940. À la fin de leur existence, le 31 juillet 1943, environ 3 600 hommes les avaient rejointes, beaucoup d’individuels venus de partout, mais aussi des membres de l’armée de l’Air stationnés dans des territoires conquis par la France libre. Ces volontaires, jeunes, d’un bon niveau de formation, animés d’une intense volonté de voler et de combattre créèrent une aviation sensiblement différente de l’armée de l’Air. Plusieurs faiblesses telles que les déficits en cadres expérimentés et personnels spécialisés ainsi que le manque d’effectifs, limitèrent cependant leur croissance.
Le cadre comme enjeu conflictuel. Conflictualité et aliénation dans les Sociétés analytiques
Authors: Babin Marc 
Published: May 2023

Bien que les ruptures dans l’histoire de la psychanalyse se produisent toujours sur le problème de la formation, la passion et la conflictualité (favorisant les maladies chroniques des sociétés analytiques, qui prennent la forme du suivisme, du clanisme et du clivage destructeur) opèrent comme « pousse à la scission ». La scission de 2005 du Quatrième Groupe, dont l’issue sera la création de la SPRF, sera étudiée pour interroger la problématique de l’aliénation transférentielle (à l’analyste, à la société analytique, au désir de devenir analyste et au savoir) et le retour du refoulé du pouvoir, de la dissimulation et de la déception présents au temps de Jacques LACAN mais aussi avec le fondateur de la psychanalyse. La théorisation de l’institution analytique serait à investir pour continuer à penser et à créer à partir de ces problématiques de formation, d’aliénation et de communauté analytique au travail.
Le cadre comme enjeu conflictuel
Authors: Colin Robert C. 
Published: May 2023

L’histoire du mouvement psychanalytique est parsemée de moments de conflits de personnes, assez passionnels, aboutissant parfois à des ruptures brutales – exclusions ou démissions à titre personnel – ainsi qu’au niveau collectif, notamment en France, à des scissions. Le tableau est le suivant : une majorité, garante de l’identité institutionnelle s’opposerait à un groupe de réformateurs un peu trop zélés. Je vous propose un survol rapide des conflits ou des tensions théoriques rencontrés par le tout jeune Freud neurologue confronté à la pensée des grands maîtres de la neurologie en espérant pouvoir saisir un élément de compréhension qui éclairerait la position épistémologique tranchée qu’il adoptera plus tard en condamnant les cadres de pensée et les visions d’ensemble au profit de la recherche pas à pas.
Neonatal presentation of a patient with Liddle syndrome, South Africa
Authors: Steyn Nicolene , Chale-Matsau Bettina , Abera Aron B. , Van Biljon Gertruida , Pillay Tahir S. 
Published: May 2023

Introduction: Liddle syndrome is an autosomal dominantly inherited disorder usually arising from single mutations of the genes that encode for the alpha, beta and gamma epithelial sodium channel (ENaC) subunits. This leads to refractory hypertension, hypokalaemia, metabolic alkalosis, hyporeninaemia and hypoaldosteronism, through over-activation of the ENaC.Case presentation: We describe a 5-day old neonate who presented with severe hypernatraemic dehydration requiring admission to Steve Biko Academic Hospital in South Africa in 2012. Further evaluation revealed features in keeping with Liddle syndrome. Two compound heterozygous mutations located at different subunits encoding the ENaC were detected following genetic sequencing done in 2020. The severe clinical phenotype observed here could be attributed to the synergistic effect of these known pathological mutations, but may also indicate that one of the other variants detected has hitherto undocumented pathological effects.Management and outcome: This child’s treatment course was complicated by poor adherence to therapy, requiring numerous admissions over the years. Adequate blood pressure control was achieved only after the addition of amiloride at the end of 2018, which raised the suspicion of an ENaC abnormality.Conclusion: To our knowledge, this is the first Liddle syndrome case where a combined effect from mutations resulted in severe disease. This highlights the importance of early recognition and management of this highly treatable genetic disease to prevent the grave sequelae associated with long-standing hypertension. Whole exome sequencing may assist in the detection of known mutations, but may also unveil new potentially pathological variants.What this study adds: This study highlights the importance of developing a high index of suspicion of tubulopathy such as Liddle syndrome for any child presenting with persistent hypertension associated with hypokalaemic metabolic alkalosis.
Follow-up attendance of patients with mental disorders and substance use disorders after inpatient treatment in psychiatry ward
Authors: Kapoor Abhinav , Ramamurthy Parthasarathy , Manikandan Mani , Thilakan Pradeep 
Published: May 2023

Abstract

Background:
The proportion of patients attending the first follow-up appointment as an outpatient after being discharged from the inpatient setting is an outcome indicator of the quality of inpatient services provided. The objectives of this study were to determine the proportion of psychiatric inpatients with mental disorders and substance use disorders attending follow-up appointments after discharge and to determine the factors associated with attending follow-up appointments in these patients.

Materials and Methods:
A retrospective chart review (observational study) was conducted among the inpatients of psychiatry ward. The list of patients admitted to the psychiatry ward was obtained from the admission register. The discharge summaries and outpatient records of these patients were reviewed to obtain the following data: sociodemographic details, clinical details, and follow-up visit details. The primary outcome variable was follow-up attendance in the outpatient department within 30 days of discharge.

Results:
Ninety-eight patient records were included in the present study. The mean age of the participants was 37.81 (11.03) years and one-third of them were female. The mean duration of hospital stay was 11.32 (8.2) days. Sixty-six (67.35%) patients attended at least one outpatient follow-up visit within 30 days after discharge from the hospital. Patients with mood disorders had 4.25 higher odds of 30-FU when compared to patients with substance use disorders.

Conclusions:
Two-thirds of psychiatric inpatients with mental disorders and substance use disorders attended follow-up appointments within 30 days after discharge. Diagnostic category was associated with attending the follow-up appointments in these patients.
A Comparative Study of Suture-less and Glue-Free versus Sutured Conjunctival Autograft for the Management of Primary Pterygium
Authors: Mahajan Sachit , Gupta Satish Kumar 
Published: May 2023

Background and Aim:
Various modalities are currently available for the management of pterygium, of which free limbal conjunctival autograft is now the most preferred method to prevent recurrence. The most common method for the fixation of autograft, at the required site, is by suturing, but it is associated with various complications. Suture-less and glue-free conjunctival autograft is a new, easy, and cheaper technique for the management of pterygium. This study was conceptualized to compare the two most commonly used techniques for conjunctival autograft fixation in pterygium surgery, either sutureless, glue-free fixation, or sutured graft.

Materials and Methods:
This prospective, longitudinal study included 100 eyes of 100 patients who were divided into two groups A and B, who underwent pterygium surgery with sutureless conjunctival autografting and sutured conjunctival autografting with 10'0 nylon sutures, respectively, under local anesthesia. Both the groups were compared with respect to mean operating time and postoperative complications. Data were analyzed with OpenEpi online software version 3 using t-test.

Results:
Mean operating time was significantly less (24.35 ± 1.22 min) in Group A as compared to Group B (28.62 ± 1.78 min) (P = 0.009). Postoperative symptoms were more in sutured conjunctival autograft group (80%) as compared to the sutureless conjunctival autograft group (10%). Two patients had graft displacement in group A. Recurrence was noted in one patient in Group A and in two patients in Group B.

Conclusion:
Sutureless and glue-free conjunctival autografting is less time-consuming and is associated with lesser postoperative complications as compared to sutured conjunctival autografting.
Silver nitrate versus histoacryl in bronchoscopic lung volume reduction
Authors: Shaaban Ahmed Y. , Shaarawy Hany M. , Abdelhady Ahmed M. , Abbas Mohanad M.H. 
Published: May 2023

Context
It is reported that chronic obstructive pulmonary disease (COPD) has a prevalence of 251 million cases worldwide in 2016. Where medical treatment failed to control or insufficiently control symptoms, and when surgical treatments are contraindicated, bronchoscopic lung volume reduction (BLVR) is considered the last option for patients with different types of severe emphysema. Sclerosing agents, such as vapor ablation or sealants, can be used.

Aim
To compare between silver nitrate and N-butyl cyanoacrylate (histoacryl) in BLVR.

Settings and design
In this randomized prospective interventional study, we recruited 24 patients with COPD from the Chest Department, Alexandria Main University Hospital, having homogenous or heterogonous emphysema and complaining of severe symptoms despite optimized medical treatment, and they were divided into group I, including 12 patients subjected to BLVRS using silver nitrate, and group II, including 12 patients subjected to BLVRS using histoacryl.

Patients and methods
Five parameters, namely, forced expiratory volume in 1 s, 5-min walk test, modified Medical Research Council, COPD assessment test score, and Saint George’s respiratory questionnaire were collected, compared, and statistically analyzed for both groups preoperatively and 12 weeks postoperatively.

Results
There were statistically significant improvements in all studied outcomes on postoperative follow-up of both groups. The only statistically significant difference between both groups was in the postoperative Saint George’s respiratory questionnaire, which was slightly better in the silver nitrate arm. None of the major complications occurred in any of the patients.

Conclusion
Both silver nitrate and histoacryl show promising results in improving patients with refractory COPD. Although both agents have nearly similar results, silver nitrate is much affordable and easier to use.
An evaluation of metered-dose inhaler administration technique among patients of asthma and chronic obstructive pulmonary disease in Saudi Arabia
Authors: Alsufyani Abdulaziz M. 
Published: May 2023

Context
Patients with asthma and chronic obstructive pulmonary disease (COPD) are majorly prescribed inhaled medications. This prescription is based on their efficacy and few adverse effects.

Aim
The study intends to evaluate metered-dose inhaler (MDI) administration technique among patients of asthma and COPD in Saudi Arabia.

Settings and design
A retrospective, cross-sectional observational design was used, and it was performed at the chest out-patient clinic at King Faisal Medical Complex, Taif, Saudi Arabia.

Materials and methods
A total of 144 Saudi patients who were diagnosed either for asthma and COPD were included. It also included patients with prescribed inhalation agents in the form of MDI.

Statistical analysis
IBM SPSS (Statistical Package for the Social Sciences) version 23.0. was used. Demographic characteristics were presented in the form of percentages and frequencies, whereas descriptive statistics were also applied. The significance value was determined at P value less than or equal to 0.05.

Results
Patients with asthma majorly used MDI technique, had unlimited attacks per month, and had experienced less than five attacks per month. The demographic evaluation showed that sex and age are insignificantly related to the use of MDI. However, education, medical diagnosis, number of asthmatic attacks per month, and duration of the MDI use were significantly related to the proper use of the MDI technique.

Conclusion
The findings of the study recommend that although patients were aware of the correct use, more training needs to be initiated. Educational intervention programs should be initiated for improving the MDI technique use among patients.
Blood eosinophil count in patients with COPD on inhaled corticosteroids in comparison with healthy smoker and nonsmoker controls
Authors: Ahmed Noha Othman , Daif Marwa Sayed , Abdel Ghani Amani Mohamed 
Published: May 2023

Background
Chronic obstructive pulmonary disease (COPD) is associated with acute and chronic pulmonary inflammation in the lung and as a systemic inflammation. The blood eosinophil counts are now recommended by the Global Initiative for the Management of Obstructive Lung Disease as a guide of inhaled corticosteroid use in clinical practice, as it can predict its effect on the rate of COPD exacerbation. The increasing peripheral blood eosinophilic count in patients with COPD could explain the systemic eosinophilia in COPD, which causes increased lung eosinophil count in these patients, especially those on inhaled corticosteroids (ICS).

Patients and methods
The study included 56 patients with COPD who were active smokers with pack-years beyond 10 as cases. The control group includes 60 patients as healthy nonsmokers (HNS) and 66 patients as healthy current smokers (HS), with pack-year beyond 10. Prebronchodilator and postbronchodilator spirometry was done in the pulmonary function unit of the Chest Department, Ain Shams University Hospital, to confirm or to exclude the COPD diagnosis. The COPD cases were categorized as per the Global Initiative for the Management of Obstructive Lung Disease severity assessment guideline and were receiving budesonide 800 μg/day and formoterol 24 μg/day or salmeterol 100 μg and fluticasone propionate 500 μg twice daily. Skin prick test and complete blood count for its differential and eosinophil count were done for all cases.

Results
The study included 56 patients with COPD who were active smokers and received ICS. The control group included 60 patients as HNS along with 66 patients as healthy current smokers. The HNS group showed the least total leukocytic count of 5588.33±1081.13/µl and the least eosinophilic count of 99.47±91.51/µl, whereas the COPD group showed the highest total leukocytic count. A statistically significant relation was found also between COPD patients’ eosinophil count and the use of ICS, with P value 0.000.

Conclusion
The peripheral blood eosinophil counts collected from patients with COPD on ICS are significantly higher than the patients with COPD who are not using ICS and the healthy smoker and nonsmoker control group.