bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrophysiologic and anti‐inflammatorial effects of cyclooxygenase inhibition in epileptiform activity
Authors: Akunal Türel Canan , Çelik Hümeyra , Çetinkaya Ayhan , Türel İdris 
Published: September 2023

AbstractThe aim of our study is to investigate the electrophysiological and anti‐inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting cyclooxygenase enzyme (COX). Wistar rats aged 2–4 months were divided into Epilepsy, Diazepam, Diclofenac potassium, and Diazepam+diclofenac potassium groups. Diazepam and diclofenac potassium were administered intraperitoneally 30 min after the epileptiform activity was created with penicillin injected intracortically under anesthesia. After the electrophysiological recording was taken in the cortex for 125 min, interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) were evaluated by the ELISA in the serums. No change was observed between the groups in serum IL‐1β, IL‐6, and TNF‐α values. It was observed that the co‐administration of diclofenac potassium and diazepam at 51–55, 56–60, 61–65, 111–115, and 116–120 min was more effective in reducing spike amplitude than diclofenac potassium alone (p < 0.05). Single‐dose diclofenac potassium did not have an anti‐inflammatory effect in epileptiform activity but both diazepam and diclofenac potassium reduced the epileptiform activity.
Investigation of mesalazine as an antifibrotic drug following myocardial infarction in male mice
Authors: Künzel Stephan R. , Winter Luise , Hoffmann Maximilian , Kant Theresa A. , Thiel Jessica , Kronstein‐Wiedemann Romy , Klapproth Erik , Lorenz Kristina , El‐Armouche Ali , Kämmerer Susanne 
Published: September 2023

AbstractObjectivesMyocardial infarction (MI) initiates a complex reparative response during which damaged cardiac muscle is replaced by connective tissue. While the initial repair is essential for survival, excessive fibrosis post‐MI is a primary contributor to progressive cardiac dysfunction, and ultimately heart failure. Currently, there are no approved drugs for the prevention or the reversal of cardiac fibrosis. Therefore, we tested the therapeutic potential of repurposed mesalazine as a post‐MI therapy, as distinct antifibrotic effects have recently been demonstrated.MethodsAt 8 weeks of age, MI was induced in male C57BL/6J mice by LAD ligation. Mesalazine was administered orally at a dose of 100 μg/g body weight in drinking water. Fluid intake, weight development, and cardiac function were monitored for 28 days post intervention. Fibrosis parameters were assessed histologically and via qPCR.ResultsCompared to controls, mesalazine treatment offered no survival benefit. However, no adverse effects on heart and kidney function and weight development were observed, either. While total cardiac fibrosis remained largely unaffected by mesalazine treatment, we found a distinct reduction of perivascular fibrosis alongside reduced cardiac collagen expression.ConclusionsOur findings warrant further studies on mesalazine as a potential add‐on therapy post‐MI, as perivascular fibrosis development was successfully prevented.
Periodontal Inflammation and Its Relationship with the Risk of Cardiovascular Diseases: Literature Review
Authors: Guevara S Espinoza , Jaramillo Y Guevara , Lagla A Chicaiza , Altamirano Gabriela Vaca 
Published: September 2023

For dental practice today, it has become important to emphasize the relevance of periodontal inflammation and oral microorganisms in the development and progression of atherosclerosis and cardiovascular diseases. Generally, the focus on PI as a causal factor of CVD is due to the great complexity and interaction that present the Gram-negative bacteria characteristic of chronic periodontal disease with the vast vascularization of the stomatognathic system. In many recent studies, researchers examined the association at the cellular and molecular level between periodontal and cardiovascular diseases. Although the specific causal correlation as a determining risk factor has not been established, it seems that periodontal disease is associated with several systemic diseases. In this connection, atherosclerosis is important in recent years. There is a possibility of an association documented in several field investigations, and this one refers to a systemic bacteremia caused by poor oral hygiene, which in turn can cause bacterial growth on the atherosclerotic plaques located in the coronary arteries, which possibly.
Determinants of male involvement in partner's cervical cancer screening in Makueni County, Kenya
Authors: Wambua Ruth T. , Onsongo Lister N. , Ndombi Eric M. 
Published: September 2023

Background: Cervical cancer is the fourth cause of cancer deaths globally and is ranked in Kenya as the second cause of cancer-related deaths among females. Men are crucial in minimizing cervical cancer burden. This study sought to establish the socio-cultural and economic factors determining male involvement in their partner's cervical cancer screening in Makueni County, Kenya.
Methods: A mixed-method cross-sectional study was used to obtain quantitative and qualitative data from men using questionnaires. Participants were married men aged 18-64 who sought services at three mid-level rural hospitals in Makueni County. Three key Informant face-to-face interviews were conducted. Quantitative data were analyzed using descriptive statistics and inferences. Qualitative data was analyzed through codes and themes.
Results: The study included 291 men. Men's involvement in their partner's cervical cancer screening was low. Only 18% of the participants showed high involvement. The participants' mean age was 38.59 (SD±10.51). Younger men (median age=33 years) were significantly more involved than their older counterparts (median age=38 years) (U=4363, p=0.020). The level of male involvement was strongly linked to the rural area of residence (p=0.001) and the hospital where the respondents were interviewed (p=0.012). Other determining factors included employment status (p=0.004), educational level (p=0.000, and spousal screening history (p=0.000). The odds of male involvement were higher in men who understood their role in cervical cancer screening than those who did not (OR=4.550, 95% CI [1.307, 15.844], p=0.017).
Conclusions: Male involvement in their partner’s cervical cancer screening remains significantly low, and demographics and sociocultural factors are key to these poor trends.
Determinants of the dividend payout policy of multinational companies in Bangladesh: Evidence from Dhaka stock exchange
Authors: Hossain Tarik , Khalifa Md. Miraz , Ahmmed Raju 
Published: September 2023

This study tries to establish the important factors influencing the dividend payout policy of the Multinational Companies (MNCs) in Bangladesh in order to assist investors in making the best possible investment decisions. Data for this study was collected from several MNCs listed on the DSE from 2015 to 2021. The relationship between the dependent variable, Dividend Payout Ratio (DPR) and selected independent variables such as Return on Equity (ROE), Liquidity Ratio (LEQR), Leverage Ratio (LEVR), Firm Size (FS), Dividend Payout Ratio of Previous Year (PDPR), Corporate Tax Ratio (CTR) and Capital Adequacy Ratio (CAR) is evaluated using Pearson's correlation and Ordinary Least Squares (OLS) regression models for data analysis and hypothesis testing. The regression analysis results showed a mixed result. The ROE and CTR are significantly related to DPR. Higher ROE and CTR emphasis a higher dividend for stock holders. The FS is significantly negatively related to DPR. Due to the costs associated with paying for the profits of substantial assets, large firms pay lower dividends. Other variables such as LEQR, LEVR, PDPR, CTR and CAR have no significant impact on the DPR. The investors and the concerned authorities can consider ROE, CTR and FS to forecast the future dividend for the MNCs in Bangladesh.
Nursing students' attitudes towards ageism and influencing factors
Authors: Kirmaci Neslihan Duman , Koç Zeliha 
Published: September 2023

This descriptive and cross-sectional study aims to determine the attitudes of nursing students toward ageism and influencing factors. The study was carried out between March 18 and April 8, 2023, with the participation of 209 students who were studying in the nursing department of the Faculty of Health Sciences of a university and volunteered to participate. The data were collected by the researchers using the questionnaire form prepared in line with the literature and the Ageism Attitude Scale (AAS). Arithmetic mean, Standard deviation, median and frequency (percent) values, Mann-Whitney U test, Kruskal-Wallis test, and Spearman correlation analysis were used to evaluate the data. In this study, it can be stated that students have a positive attitude towards ageism in line with the scores they receive from the AAS. In line with the findings obtained from the study, it is recommended to organize scientific activities and ensure the participation of students to increase students' awareness of ageism and to ensure that they gain a positive attitude.
Keywords: Ageism; attitude; elderly; nurse; student.
A scoping review examining patient experience and what matters to people experiencing homelessness when seeking healthcare
Authors: Miller Jean-Philippe , Hutton Jennie , Doherty Claire , Vallesi Shannen , Currie Jane , Rushworth Katrina , Larkin Matthew , Scott Matthew , Morrow James , Wood Lisa 
Published: September 2023

Abstract

Background: Homelessness is associated with significant health disparities. Conventional health services often fail to address the unique needs of homeless individuals. This scoping review aimed to examine areas of patient experience that are most frequently reported by people experiencing homelessness when seeking and receiving healthcare, and to identify existing surveys used to measure patient experience for this cohort.
Methods:
A scoping review was undertaken reported according to the PRISMA-ScR 2020 Statement. Databases were searched on 1 December 2022: MEDLINE, EMBASE, APA PsychINFO and CINAHL. Included studies focused on people experiencing homelessness, healthcare services and patient experience, primary research, published in English from 2010. Qualitative papers and findings were extracted and synthesized against a modified framework based on the National Institute for Health and Care Excellence guidelines for integrated health and social care for people experiencing homelessness, the Institute of Medicine Framework for Health Care Quality, and Lachman’s multidimensional quality model.
Results: 31 studies were included. Of these, 21 were qualitative, seven quantitative and three mixed methods, from the United States of America (n=16), United Kingdom (n=5), Australia (n=5) and Canada (n=4). Health services ranged from primary healthcare to outpatient management, acute care, emergency care and hospital-based healthcare. In qualitative papers, the domains of ‘accessible and timely’, ‘person-centred’, and values of ‘dignity and respect’ and ‘kindness with compassion’ were most prevalent. Among the three patient experience surveys identified, ‘accessible and timely’ and ‘person-centred’ were the most frequent domains. The least frequently highlighted domains and values were ‘equitable’ and ‘holistic’. No questions addressed the ‘safety’ domain.
Conclusions: The Primary Care Quality-Homeless questionnaire best reflected the priorities for healthcare provision that were highlighted in the qualitative studies of people experiencing homelessness. The most frequently cited domains and values that people experiencing homelessness expressed as important when seeking healthcare were reflected in each of the three survey tools to varying degrees. Findings suggest that the principles of ‘Kindness and compassion’ require further emphasis when seeking feedback on healthcare experiences and the domains of ‘safety’, ‘equitable’, and ‘efficiency’ are not adequately represented in existing patient experience surveys.
Mycorrhizal fungi respiration dynamics in relation to gross primary production in a Hungarian dry grassland
Authors: De Luca Giulia , Papp Marianna , Fóti Szilvia , Posta Katalin , Mészáros Ádám , Pintér Krisztina , Nagy Zoltán , Péli Evelin Ramóna , Fekete Sándor , Balogh János 
Published: September 2023

Abstract
Aims: Soil respiration (Rs) is a highly complex process including a wide range of soil biota and different pathways of carbon cycling, all being under the control of various drivers. The most important biotic driver is the photosynthetic activity of the vegetation providing supply mainly for the autotrophic component of Rs: roots and their symbiotic partners. The objective of this study was to describe the time-lagged relationship between gross primary production (GPP) and the mycorrhizal Rs component in order to determine the amount of carbon derived from GPP appearing as mycorrhizal respiration (Rmyc).
Methods: Measurements of Rs were conducted in three treatments – i) undisturbed, root and AMF-included (Rs), ii) root-excluded (Rhet+myc) and iii) root- and AMF-excluded (Rhet) plots – for three consecutive years in the Central-Hungarian dry sandy grassland study site. GPP data were derived from eddy-covariance measurements, while an automated system was used for continuous measurements of Rs. We analysed the relationship between Rmyc and GPP by using cross-correlation and by fitting sine wave models on the diel datasets.
Results: GPP was found to be the main driver of Rmyc, responding with an average time lag of 18 hours. The greatest lags were detected during periods characterized by minimal photosynthetic activity, while lags tended to be the smallest during active periods.
Conclusion: Based on the seasonal changes in the delay, we concluded that GPP and soil temperature had simultaneous effects on the diel pattern of CO2 emission of the different autotrophic components depending on the vegetation activity and environmental conditions.
Establishment and validation of nomogram model for predicting recurrence of common bile duct stones after ERCP lithotomy
Authors: Zhao Shupeng , Zhai Leilei , Yang Tao , Yao Ping 
Published: September 2023

Abstract
Background
Currently, the definitive determination of risk factors linked to the recurrence of common bile duct stones remains elusive, and there is a scarcity of accurate prognostic instruments for predicting recurrence in clinical contexts. The aim of this study is to examine the high-risk factors that contribute to recurrence subsequent to endoscopic retrograde cholangiopancreatography (ERCP) stone extraction and develop a nomogram model founded on these factors.
Methods
This study conducted a retrospective analysis of clinical data obtained from patients who underwent ERCP stone extraction at the Department of Gastroenterology in the First Affiliated Hospital of Xinjiang Medical University during the period from January 1, 2016, to December 31, 2020. The study population consisted of 409 patients in the modeling group and 163 patients in the validation group. The Cox regression model was employed to identify independent risk factors associated with stones recurrence, which were subsequently utilized to develop a nomogram for predicting the probability of stones recurrence following ERCP.
Results
The Cox multivariate analysis revealed that several factors were found to be significantly associated with an increased risk of recurrence following ERCP stone removal. These factors included a body mass index (BMI) of ≥ 24 kg/m2 (hazard ratio (HR) = 2.625, 95% confidence interval (CI): 1.380–4.993, P = 0.003), a triglyceride level of ≥ 1.31 mmol/l (HR = 1.960, 95% CI: 1.106–3.473, P = 0.021), a common bile duct diameter of ≥ 1.2 cm (HR = 3.451, 95% CI: 1.359–8.766, p = 0.009), and a common bile duct stone diameter of ≥ 1 cm (HR = 6.047, 95% CI: 2.371–15.417, p < 0.001). Furthermore, a nomogram model was developed incorporating these four parameters, which demonstrated robust discriminatory power.
Conclusion
The prediction model that has been developed exhibits a significant degree of accuracy in predicting the recurrence of stones, thus possessing considerable significance in guiding the subsequent monitoring of patients and the implementation of preventive measures.
Impact of Post-transplant cyclophosphamide (PTCy)-Based Prophylaxis in Matched Sibling Donor Allogeneic Haematopoietic Cell Transplantation for Patients with Myelodysplastic Syndrome: A Retrospective Study on Behalf of the Chronic Malignancies Working Party of the EBMT
Authors: McLornan Donal , Salas Maria , Eikema Dirk-Jan , Koster Linda , Maertens Johan , Passweg Jakob , Finke Jürgen , Broers Annoek , Koc Yener , Kroeger Nicolaus , Ozkurt Zubeyde , Pascual María , Platzbecker Uwe , Gorkom Gwendolyn Van , Schroeder Thomas , Lorenzo Jose López , Martino Massimo , Chiusolo Patrizia , Kaufmann Martin , Onida Francesco , Gurnari Carmelo , Scheid Christof , Drozd-Sokolowska Joanna , Raj Kavita , Robin Marie 
Published: September 2023

Abstract
Allo-HCT remains the only curative option for individuals with myelodysplastic syndrome (MDS). Use of PTCy for GVHD prevention is increasingly prevalent. We retrospectively compared outcomes of 404 MDS patients undergoing 1st matched sibling donor allo-HCT receiving either PTCy-based (n=66) or other ‘conventional prophylaxis’ (n=338; mostly calcineurin inhibitor + methotrexate or MMF). Baseline characteristics were balanced, except for higher use of myeloablative regimens in the PTCy group (52.3% vs. 38.2%, p=0.047). Day +28 incidences of neutrophil (68% vs. 97%, p=0.011) and platelet (71% vs. 92%, p<0.001) engraftment were lower for PTCy-based. Day +100 cumulative incidences (CI) of grade II-IV and III-IV aGVHD, and 5-y CI of extensive cGVHD were 32%, 18% and 18% for PTCy-based and 25% (p=0.3), 13% (p=0.4) and 31% (p=0.09) for the conventional cohort. Five-year OS (51% vs. 52%, p=0.6) and GRFS (33% vs. 25%, p=0.6), were similar between groups. Patients receiving PTCy had a trend to lower relapse (20% vs. 33% (p=0.06)) not confirmed on multivariate analysis (p=0.3). Higher NRM rates, however, were evident with PTCy use on multivariable analysis (HR 1.79, p=0.03), without affecting OS (HR 1.23, p=0.4). Based on these data, the indication of PTCy in this setting should be questioned and needs further evaluation.
Intimate partner violence during pregnancy and its impact on early initiation of breastfeeding: Exploring mediation and moderation by childbirth complications
Authors: Islam Md Jahirul 
Published: September 2023

Abstract
Background
Recent research has unveiled a significant link between intimate partner violence (IPV) during pregnancy and challenges in the early initiation of breastfeeding (EIBF) among new mothers. Nonetheless, the potential mechanisms underpinning this interconnection remain elusive.
Objectives
This study aims to investigate two pivotal aspects: 1) the link between various forms of IPV during pregnancy and EIBF in Bangladesh; and 2) the potential mediating and moderating role of complications during childbirth in this association.
Methods
A cross-sectional study was undertaken among 426 new mothers of Bangladesh aged 15–49 years who were six months postpartum. IPV was evaluated using a modified version of the domestic violence questionnaire of the WHO Multi-country study. The timing of breastfeeding initiation was determined by asking mothers how long after the birth they put their infant to the breast.
Results
Nearly three in five women reported EIBF. Based on the adjusted logistic regression model, women subjected to physical and sexual IPV during pregnancy were respectively 46% (AOR: 0.54, 95% CI [0.31, 0.96]) and 51% (AOR: 0.49, 95% CI [0.27, 0.87]) less likely to engage in EIBF, compared to non-abused counterparts. Additionally, complications during childbirth were found to both mediate and moderate the link between IPV and EIBF, even after adjusting for pertinent covariates. Specifically, mothers experiencing both IPV during pregnancy and childbirth complications reported a significantly lower likelihood of EIBF.
Conclusions
The current findings underscore how IPV during pregnancy can adversely affect maternal breastfeeding practices. Healthcare providers and birth attendants should recognize that mothers experiencing IPV during pregnancy, coupled with childbirth complications, are less inclined to embrace EIBF. Policy interventions concerning antenatal and postnatal care should incorporate IPV screening and breastfeeding support to enhance EIBF rates.
Use of histochemical techniques for accurate diagnosis of melanocytic neoplasms in dogs
Authors: SUZUKI Livia Yumi , WATERLOO Mateus Melo Lima , CONSALTER Angélica , FERREIRA Ana Maria Reis , LEITE Juliana 
Published: September 2023

Abstract
Cutaneous and oral melanocytic neoplasms of dogs have several histomorphological presentations and varied cytoplasmic pigmentation that can make difficult the histopathological diagnosis. The aim of this study was to evaluate the benefits of using Fontana Masson and bleaching in histopathology routine for the diagnosis of melanocytic neoplasms in dogs. Thirty-one samples diagnosed as melanocytic neoplasms were analyzed, among which, 21 are cutaneous neoplasms (13 melanomas and 8 melanocytomas); and 10 are oral melanomas. The samples with accentuated pigmentation were submitted to the bleaching technique (20), whereas the amelanotic samples were submitted to the Fontana Masson staining (11). In the bleached samples, a reassessment of nuclear pleomorphism and mitosis count was performed according to the guideline. In this study, two pigmented cutaneous neoplasms with obscured nuclei had their final diagnoses reconsidered after performing the bleaching technique. The Fontana Masson technique was performed on 11 amelanotic or slightly pigmented samples. Among them, six samples were oral melanomas, four cutaneous melanomas and one melanocytoma. In 10 samples it was possible to visualize argentaffin pigment evidenced by the technique. In an amelanotic skin sample, there was no marking using the Fontana Masson technique, which was referred for immunohistochemistry to confirm the diagnosis. Histochemical techniques employed in this study proved to be useful tools in the histopathological routine, with low cost, easy and quick execution. When used together with the recommendations of the guidelines for melanocytic neoplasms, they help both in differentiating the neoplasm and in determining the most accurate prognosis.