bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tragedy of the common? A comparative population genomic study of two bumblebee species
Authors: Huml Jana V. , Ellis Jonathan S. , Rustage Sarah , Brown Mark J. F. , Billington Richard , Knight Mairi E. 
Published: January 2023

Abstract
Within the theoretical framework of the small population paradigm, we investigated the population genomics and parasite load of two bumblebee species across the UK and Ireland. Bombus pratorum is widespread and common throughout its range while Bombus monticola is restricted to higher altitudes and shows a more fragmented distribution.
Bombus monticola showed stronger population structuring, isolation‐by‐distance, and a deficit of heterozygotes in the most isolated population in the south of its range (Dartmoor). Heterozygosity and inbreeding coefficients (FIS) were comparable between both species, but the proportion of polymorphic sites was much greater in B. pratorum. Notably, both species have suffered significant declines in Ne over the last 100 generations and estimates and declines for both species were of similar orders of magnitude. No pattern of increased parasite prevalence in populations of lower heterozygosity was observed. Instead, ecological and demographic factors (age, latitude, date, habitat suitability) were the main drivers of parasite prevalence.
Distinct patterns of selection were observed in both species in regions involved in regulation of transcription and neurotransmission and in particular pathways targeted by neonicotinoid insecticides.
Our results highlight the pressing need for monitoring to include common as well as rare species. This should not focus solely on census population counts, but include estimates of Ne. We also highlight the need for further work to establish adaptive shifts in globally important pollinator communities.
Évaluer les pratiques des entreprises en matière de travail décent: une analyse des méthodologies de notation ESG
Authors: LOUCHE Céline , DELAUTRE Guillaume , BALVEDI PIMENTEL Gabriela 
Published: January 2023

RésuméLes agences de notation spécialisées dans l‘évaluation des pratiques des entreprises en matière environnementale, sociale et de gouvernance (ESG) sont des partenaires importants pour les acteurs de l'investissement responsable, qu'elles alimentent en données extrafinancières. Si la question des indicateurs ESG a déjà été traitée dans la littérature, la façon d‘évaluer le travail décent est peu documentée. Les auteurs observent les pratiques de six agences de notation ESG pour comprendre comment ces organismes mesurent et évaluent la performance en matière de travail décent, et avec quelles difficultés, et pour déterminer si l'investissement responsable et les notations ESG peuvent véritablement promouvoir le travail décent dans les entreprises.
Factors influencing turnover intention among male nurses in China: A large‐scale descriptive correlational study
Authors: Chen Jiang‐Ping , Dai Yu‐Mei , Qin Yong , Liang Sheng‐Peng , Cheng Gen , Liu Yang , Yang Cheng‐Zu , He Hong‐Gu , Shen Qu 
Published: January 2023

AbstractAimThis study examined the correlation among turnover intention, emotional intelligence and job burnout in male nurses and determined its influencing factors.BackgroundThe number of male nurses has increased in China; however, the turnover rate is very high. Nurses’ turnover intention is related to job burnout and emotional intelligence.IntroductionRecent studies have shown that job burnout and emotional intelligence are related to medical and health institution employees’ intention to leave their jobs. It is not clear if the same conclusions can be drawn about male nurses.MethodsFor this cross‐sectional study, 627 male nurses were recruited from across China between May and July 2018. Data were collected through an online questionnaire, and Pearson's product‐moment correlation coefficient and multiple linear regression were performed to analyse the data.ResultsThere was a weak negative, moderate positive and moderate negative correlation between turnover intention and emotional intelligence, turnover intention and job burnout, and emotional intelligence and job burnout, respectively. Factors that significantly affected turnover intention among male nurses included job burnout, young age, lack of interest in nursing and working in the emergency department.ConclusionThe study revealed the factors that affected male nurses’ turnover intention and the relationships between turnover intention, emotional intelligence and job burnout.Implications for Nursing Management and Social PolicyHospital managers should provide necessary help and support to reduce male nurse turnover rates and incorporate emotional intelligence training. The policy should eliminate the unfair college admission practices for students choosing nursing majors, raise the nursing profession's salaries and vigorously develop specialty nursing. In addition, diversified values should be promoted, and stereotypes of male nurses in nursing should be broken.
Tapinarof for psoriasis and atopic dermatitis: 15 years of clinical research
Authors: Bissonnette R. , Saint‐Cyr Proulx E. , Jack C. , Maari C. 
Published: January 2023

AbstractTapinarof is a topical, aryl‐hydrocarbon receptor agonist that has recently received FDA‐approval for the treatment of psoriasis. This novel therapeutic has also been shown to be effective for atopic dermatitis and is currently in phase 3 for this indication. Beyond good efficacy and fast onset of action in patients with psoriasis, the clinical response to tapinarof is notable for durable remission or near remission, maintained for an average of 130 days beyond treatment discontinuation in patients with psoriasis in phase 3 studies. Tapinarof is usually well tolerated but can induce a follicular inflammatory reaction and dermatitis in some patients. This narrative review covers the historical development of this molecule, safety and efficacy data from clinical trials conducted with various topical formulations, and practical considerations derived from our 15 years of clinical trial experience with the drug.
Changing Supply Elasticities and Regional Housing Booms
Authors: AASTVEIT KNUT ARE , ALBUQUERQUE BRUNO , ANUNDSEN ANDRÉ K. 
Published: January 2023

AbstractDevelopments in U.S. house prices over the past decade mirror those of the 1996–2006 boom. Construction activity has, however, been weak. Using data for 254 U.S. metropolitan areas, we show that housing supply elasticities have fallen markedly in recent years. We find that housing supply elasticities have declined more in areas in which land‐use regulation has tightened the most, and in areas that experienced the sharpest housing busts. Consistent with the declining housing supply elasticities, we find that monetary policy shocks have had a stronger effect on house prices during the past decade than during the previous boom. At the same time, building permits respond less.
Embryonic and skeletal development of the albino African clawed frog (Xenopus laevis)
Authors: Shan Zhixin , Li Shanshan , Yu Chenghua , Bai Shibin , Zhang Junpeng , Tang Yining , Wang Yutong , Irwin David M. , Li Jun , Wang Zhe 
Published: January 2023

AbstractThe normal stages of embryonic development for wild‐type Xenopus laevis were established by Nieuwkoop and Faber in 1956, a milestone in the history of understanding embryonic development. However, this work lacked photographic images and staining for skeleton structures from the corresponding stages. Here, we provide high‐quality images of embryonic morphology and skeleton development to facilitate studies on amphibian development. On the basis of the classical work, we selected the albino mutant of X. laevis as the observation material to restudy embryonic development in this species. The lower level of pigmentation makes it easier to interpret histochemical experiments. At 23°C, albino embryos develop at the same rate as wild‐type embryos, which can be divided into 66 stages as they develop into adults in about 58 days. We described the complete embryonic development system for X. laevis, supplemented with pictures of limb and skeleton development that are missing from previous studies, and summarized the characteristics and laws of limb and skeleton development. Our study should aid research into the development of X. laevis and the evolution of amphibians.
Fatigue in nurses and medication administration errors: A scoping review
Authors: Bell Tracey , Sprajcer Madeline , Flenady Tracey , Sahay Ashlyn 
Published: January 2023

AbstractBackgroundMedication administration errors (MAEs) cause preventable patient harm and cost billions of dollars from already‐strained healthcare budgets. An emerging factor contributing to these errors is nurse fatigue. Given medication administration is the most frequent clinical task nurses undertake; it is vital to understand how fatigue impacts MAEs.ObjectiveExamine the evidence on the effect of fatigue on MAEs and near misses by registered nurses working in hospital settings.MethodArksey and O'Malley's scoping review framework was used to guide this review and PAGER framework for data extraction and analysis. The PRISMA checklist was completed. Four electronic databases were searched: CINAHL, PubMed, Scopus and PsycINFO. Eligibility criteria included primary peer review papers published in English Language with no date/time limiters applied. The search was completed in August 2021 and focussed on articles that included: (a) registered nurses in hospital settings, (b) MAEs, (c) measures of sleep, hours of work, or fatigue.ResultsThirty‐eight studies were included in the review. 82% of the studies identified fatigue to be a contributing factor in MAEs and near misses (NMs). Fatigue is associated with reduced cognitive performance and lack of attention and vigilance. It is associated with poor nursing performance and decreased patient safety. Components of shift work, such as disruption to the circadian rhythm and overtime work, were identified as contributing factors. However, there was marked heterogeneity in strategies for measuring fatigue within the included studies.Relevance to clinical practiceFatigue is a multidimensional concept that has the capacity to impact nurses' performance when engaged in medication administration. Nurses are susceptible to fatigue due to work characteristics such as nightwork, overtime and the requirement to perform cognitively demanding tasks. The mixed results found within this review indicate that larger scale studies are needed with particular emphasis on the impact of overtime work. Policy around safe working hours need to be re‐evaluated and fatigue management systems put in place to ensure delivery of safe and quality patient care.
Effects of immunocastration and supplementary feeding level on the performance and blood biochemical markers of farmed yearling fallow deer (Dama dama)
Authors: Ny Veit , Needham Tersia , Bartoň Luděk , Bureš Daniel , Kotrba Radim , Musa Abubakar S. , Ceacero Francisco 
Published: January 2023

AbstractIn cervids, blood biochemical markers may reflect changes in various physiological and environmental factors, especially in response to changes in metabolism following nutrient supplementation or the manipulation of hormone production. Decreasing androgen production through immunocastration (IC) to ease the husbandry of male animals is currently a more ethically acceptable method than physical castration, but its commercial use is unexplored in fallow deer. Forty yearlings male fallow deer were grouped into four treatment combinations: IC on high (200 g commercial pellets + 600 g concentrate mixture of 90% oats and 10% wheat grains) or low (100 g commercial pellets + 300 g concentrate mixture of 90% oats and 10% wheat grains) level of feed supplementation, or noncastrated bucks on a high or low level of feed supplementation. Immunocastrated animals were vaccinated at the start of the study (Week 1) and again during Week 3 of the study. Diet affected all body growth parameters (slaughter weight, daily gain, carcass weight, dressing percentage and body condition score). Fallow deer from all treatments showed increasing concentrations of fat and energy blood biochemical markers over the study period, including plasma glucose (GLU) and triglyceride (TRIG), and decreased cholesterol (CHOL) and lipase (LIPA) concentrations. The higher level of supplementary feeding decreased plasma albumin (ALB) and creatinine (CREA), and increased globulin (GLOB) concentrations. On the other hand, IC and lower‐level supplementation reduced growth performance. Overall, IC may be an interesting tool for welfare management of yearling stags for slaughter; however, the advantage appears to only be in well‐fed animals, as low‐level of feeding can further reduce growth performance in immunocastrated animals. Further studies should evaluate the carcass performance of animals under similar treatment conditions to ascertain the effects on muscle and fat yields.
Fetal and infant growth patterns, sleep, and 24‐h activity rhythms: a population‐based prospective cohort study in school‐age children
Authors: Beunders Victoria A. A. , Koopman‐Verhoeff M. Elisabeth , Vermeulen Marijn J. , Silva Carolina C. V. , Jansen Pauline W. , Luik Annemarie I. , Reiss Irwin K. M. , Joosten Koen F. M. , Jaddoe Vincent W. V. 
Published: January 2023

SummaryThe study objective was to explore associations of fetal and infant weight patterns and preterm birth with sleep and 24‐h activity rhythm parameters at school‐age. In our prospective population‐based study, 1327 children were followed from birth to age 10–15 years. Fetal weight was estimated using ultrasound in the second and third trimester of pregnancy. Birth weight and gestational age were available from midwife registries. Infant weight was measured at 6, 12 and 24 months. Fetal and infant weight acceleration or deceleration were defined as a change of >0.67 standard deviation between the corresponding age intervals. At school‐age, sleep duration, sleep efficiency, wake after sleep onset, social jetlag, inter‐daily stability, and intra‐daily variability were assessed using tri‐axial wrist actigraphy for 9 consecutive nights. We observed that low birth weight (<2500 g) was associated with 0.24 standard deviation (95% confidence interval [CI] 0.04; 0.43) longer sleep duration compared to normal weight. Compared to normal growth, growth deceleration in fetal life and infancy was associated with 0.40 standard deviation (95% CI 0.07; 0.73) longer sleep duration, 0.44 standard deviation (95% CI 0.14; 0.73) higher sleep efficiency, and −0.41 standard deviation (95% CI −0.76; ‐0.07) shorter wake after sleep onset. A pattern of normal fetal growth followed by infant growth acceleration was associated with −0.40 standard deviation (95% CI −0.61; −0.19) lower inter‐daily stability. Preterm birth was not associated with any sleep or 24‐h rhythm parameters. Our findings showed that children with fetal and infant growth restriction had longer and more efficient sleep at school‐age, which may be indicative of an increased need for sleep for maturational processes and development after a difficult start in life.
Multiple transitions between realms shape relict lineages ofProteuscave salamanders
Authors: Recknagel H. , Zakšek V. , Delić T. , Gorički Š. , Trontelj P. 
Published: January 2023

AbstractIn comparison to biodiversity on Earth's surface, subterranean biodiversity has largely remained concealed. The olm (Proteus anguinus) is one of the most enigmatic extant cave inhabitants, and until now little was known regarding its genetic structure and evolutionary history. Olms inhabit subterranean waters throughout the Dinaric Karst of the western Balkans, with a seemingly uniform phenotypic appearance of cave‐specialized traits: an elongate body, snout and limbs, degenerated eyes and loss of pigmentation (“white olm”). Only a single small region in southeastern Slovenia harbours olms with a phenotype typical of surface animals: pigmented skin, eyes, a blunt snout and short limbs (“black olm”). We used a combination of mitochondrial DNA and genome‐wide single nucleotide polymorphism data to investigate the molecular diversity, evolutionary history and biogeography of olms along the Dinaric Karst. We found nine deeply divergent species‐level lineages that separated between 17 and 4 million years ago, while molecular diversity within lineages was low. We detected no signal of recent admixture between lineages and only limited historical gene flow. Biogeographically, the contemporaneous distribution of lineages mostly mirrors hydrologically separated subterranean environments, while the historical separation of olm lineages follows microtectonic and climatic changes in the area. The reconstructed phylogeny suggests at least four independent transitions to the cave phenotype. Two of the species‐level lineages have miniscule ranges and may represent Europe's rarest amphibians. Their rarity and the decline in other lineages call for protection of their subterranean habitats.
Non‐specific and specific DNA binding modes of bacterial histone, HU, separately regulate distinct physiological processes through different mechanisms
Authors: Verma Subhash C. , Harned Adam , Narayan Kedar , Adhya Sankar 
Published: January 2023

AbstractThe histone‐like protein HU plays a diverse role in bacterial physiology from the maintenance of chromosome structure to the regulation of gene transcription. HU binds DNA in a sequence‐non‐specific manner via two distinct binding modes: (i) random binding to any DNA through ionic bonds between surface‐exposed lysine residues (K3, K18, and K83) and phosphate backbone (non‐specific); (ii) preferential binding to contorted DNA of given structures containing a pair of kinks (structure‐specific) through conserved proline residues (P63) that induce and/or stabilize the kinks. First, we show here that the P63‐mediated structure‐specific binding also requires the three lysine residues, which are needed for a non‐specific binding. Second, we demonstrate that substituting P63 to alanine in HU had no impact on non‐specific binding but caused differential transcription of diverse genes previously shown to be regulated by HU, such as those associated with the organonitrogen compound biosynthetic process, galactose metabolism, ribosome biogenesis, and cell adhesion. The structure‐specific binding also helps create DNA supercoiling, which, in turn, may influence directly or indirectly the transcription of other genes. Our previous and current studies show that non‐specific and structure‐specific HU binding appear to have separate functions‐ nucleoid architecture and transcription regulation‐ which may be true in other DNA‐binding proteins.
The Necessity of Primary Causes: A Critique of Denis Edwards
Authors: McGowan Emma 
Published: January 2023

AbstractIn this paper I will investigate a recent development on St Thomas Aquinas’ definition of dual causality and see if it truly develops Aquinas’ thinking or departs from it. Denis Edwards made significant contributions to contemporary Catholic theology especially as it concerns the relationship between science and Christian theology. In one very interesting publication, ‘Toward a Theology of Divine Action’, Edwards employs the developments of William R Stoeger, a Jesuit theologian who has also contributed a great deal to Catholic thought on science, to reconcile Stoeger's work with the Thomist tradition. Edwards argued that Stoeger's account of the laws of nature creates a space for the development which is built on Aquinas’ account of divine causality and miracles. However, I hope to show that Edwards’ account of divine causality does not actually offer anything new and opposes key features of Thomist thought. This paper will investigate Edward's understanding of the Thomist position and the consequences of departing from it.
Happle‐Tinschert syndrome variable phenotype as part of the mosaic hedgehog spectrum: Report of three cases
Authors: Cano Ramiro , Abad María Eugenia , Schanze Denny , Zenker Martin , Serafin Eva , Larralde Margarita 
Published: January 2023

AbstractHapple‐Tinschert syndrome is a rare genodermatosis caused by a postzygotic mutation in SMO gene. The most recognized clinical findings include segmentally arranged basaloid follicular hamartomas, nevoid hypertrichosis, linear atrophoderma, and hypopigmentation or hyperpigmentation following Blaschko lines associated with osseous, dental, and cerebral alterations. We report three additional cases, two of which lacked the pathognomonic basaloid follicular hamartomas, with genetic confirmation and detailed clinical characterization and describe new cutaneous features of this infrequent syndrome.
Transcriptome analysis reveals the fruit color variation in Ailanthus altissima
Authors: Ma Yaping , Devi Mura Jyostna , Feng Xuerui , Li Yunmao , Song Lihua , Gao Handong , Cao Bing 
Published: January 2023

AbstractAnthocyanins are responsible for the intensity of color in plants; however, the systematic mechanisms underlying the color differences in the fruit of Ailanthus altissima remain unknown. Therefore, this study aims to analyze the transcriptomes of the white and red fruit of A. altissima by screening and validating the key genes involved in flavonoid and anthocyanin biosynthesis. Samples of A. altissima fruit were collected 30, 45, and 60 days after flowering, and their pigment and sugar content were determined. The anthocyanin content was significantly higher in red than in white fruits. Transcriptome analysis was also performed on the fruit samples, 73,807 unigenes were assembled and annotated to seven databases. Twenty‐one co‐expressed modules were identified via weighted gene co‐expression network analysis, of which two were associated with flavonoids and anthocyanins. Furthermore, in three growth stages, 126, 30, and 124 differentially expressed genes were screened between white and red fruit. Genes involved in flavonoid and anthocyanin metabolism were identified. AaDFR (A. altissima bifunctional dihydroflavonol 4‐reductase/flavanone 4‐reductase) and AaANS (A. altissima anthocyanidin synthase) were associated with flavonoid and anthocyanin metabolism. Members of the AaDFR and AaANS families were also identified, and their basic physicochemical characteristics, conserved domains, motif compositions, phylogenetics, and expression levels were analyzed. The overexpression of AaDFR and AaANS in transgenic Arabidopsis significantly increased the content of seed and foliar flavonoids and anthocyanins. The study elucidated the different mechanisms underlying fruit color development and provided insight into A. altissima plants breeding with commercially desirable properties.