bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent high-intensity interval training and probiotic supplementation improve associative memory via increase in insulin sensitivity in ovariectomized rats
Authors: Bayat Zeinab , Damirchi Arsalan , Hasannejad-Bibalan Meysam , Babaei Parvin 
Published: July 2023

Abstract
Objectives
Metabolic syndrome (MetS) is a serious concern among postmenopausal women which predisposes them to cardiovascular and cognitive disorders. Healthful diet and exercise training have been essential strategies to prevent the progress of MetS. The aim of this study was to evaluate the effect of supplementation with a native potential probiotic and high-intensity interval training (HIIT) for 8 weeks on retention of associative memory in rats with ovariectomy- induced metabolic syndrome.

Method
Thirty-two female ovariectomized Wistar rats were divided into four groups (n = 8/group): Control (OVX + Veh), exercise (OVX + Exe), probiotic (OVX + Pro), exercise with probiotic (OVX + Exe + Pro). One sham surgery group was included as a control group. Animals received 8 weeks interventions, and then were tested in a step through passive avoidance learning and memory paradigm, to assess long term memory. Then serum levels of adiponectin, insulin and glucose were measured by ELISA and colorimetry respectively. Data were analyzed by Kruskal-Wallis, Mann-Whitney and also One-way analysis of variance (ANOVA).

Results
Eight weeks of HIIT and probiotic supplementation caused an increase in step through latency and shortening of total time spent in the dark compartment in OVX + Exe + Pro group compared with OVX + Veh group. Also significant increase in serum adiponectin levels, in parallel with a reduction in glucose, insulin and HOMA-IR were achieved by the group of OVX + Exe + Pro.

Conclusion
The present study indicates that HIIT combined with probiotics supplementation for 8 weeks effectively improves associative memory in MetS model of rats partly via improving insulin sensitivity and adiponectin level.
Impact of value similarity on social trust in medical students: a cross-sectional web survey
Authors: Kondo Satoshi , Ichikawa Shuhei , Izumiya Masashi , Eto Masato 
Published: July 2023

Abstract
Background
Social trust in medical students is trust in the cluster of medical students and not individual medical students. Social trust in medical students seems critical in clinical practice since citizens often face unknown medical students for the first time. However, most previous research has focused on interpersonal trust in particular medical professions, and social trust in medical students has not been addressed sufficiently. In social science, the Salient Value Similarity model has demonstrated that the value similarity between professionals and citizens is associated with social trust. This research aimed to explore the relationship between social trust in medical students and the perception of value similarity. This study also aimed to determine whether the information of medical students strengthens social trust in them.

Methods
We conducted a cross-sectional study to investigate how the perception of value similarity affects social trust. The participants answered the social trust questionnaires before and after reading a brief summary of the medical education curriculum and certification via the internet in Japan. The model structure of social trust in medical students, including the perception of value similarity, was investigated using SEM. A paired t-test was used to examine the effect of informing citizens about the knowledge, skills, and professionalism requirements of students attending medical school on social trust by reading the brief summary.

Results
The study included 658 participants, who all answered a web questionnaire. Social trust in medical students was associated with the perception of ability and value similarity. Social trust in medical students, the perception of ability, and value similarity were improved by information about medical students.

Conclusions
The perception of ability and value similarity seem to affect social trust in medical students. Information on medical education regarding the knowledge, skills, and professionalism of medical students may improve social trust in these students. Further research is required to sophisticate the model of social trust in medical students by exploring social trust in the medical students’ supervisors in clinical settings.
Chinese medical entity recognition based on the dual-branch TENER model
Authors: Peng Hui , Zhang Zhichang , Liu Dan , Qin Xiaohui 
Published: July 2023

Abstract
Background
Named Entity Recognition (NER) is a long-standing fundamental problem in various research fields of Natural Language Processing (NLP) and has been practiced in many application scenarios. However, the application results of NER methods in Chinese electronic medical records (EMRs) are not satisfactory, mainly due to the following two problems: (1) Existing methods do not take into account the impact of medical terminology on model recognition performance, resulting in poor model performance. (2) Existing methods do not fully utilize the Chinese language features contained in EMR, resulting in poor model robustness. Therefore, it is imminent to solve these two problems regarding the performance of the NER model for EMRs.

Methods
In this paper, a TENER-based radical feature and entity augmentation model for NER in Chinese EMRs is proposed. The TENER model is first used in the pre-training stage to extract deep semantic information from each layer of the feature extractor. In the decoder part, the recognition of medical entity boundary and entity category are divided into two branch tasks.

Results
We compare the overall performance of the proposed model with existing models on different datasets using the computed F1 score evaluation metric. The experimental results show that our model achieves the best F1 score of 82.67%, 74.37%, 70.16% on the CCKS2019, ERTCMM, and CEMR data sets. Meanwhile, in the CMeEE challenge, our model surpassed the top-3 with the F1 score of 68.39%.

Conclusions
Our proposed model is the first to divide the NER task into a two-branch tasks, entity boundary and types recognition. Firstly, the medical entity dictionary information is integrated into TENER to obtain the feature information of professional terms in Chinese EMRs. Secondly, the features of Chinese radicals in Chinese EMRs extracted by CNN are added to the entity category recognition task. Finally, the effectiveness of the model is validated on four datasets and competitive results are achieved.
Strategic planning to improve surgical, obstetric, anaesthesia, and trauma care in the Asia–Pacific region: introduction
Authors: Qin Rennie X. , Fowler Zachary G. , Yoon Sangchul , Jayaram Anusha , Stankey Makela , Keshavjee Salmaan , Holian Annette , Ibbotson Geoff , Park Kee B. 
Published: July 2023

AbstractSurgical, obstetric, and anaesthesia care are required to treat one-third of the global disease burden. They have been recognised as an integral component of universal health coverage. However, five billion people lack access to safe and affordable surgical care when required. Countries in the Asia–Pacific region are currently developing strategies to strengthen their surgical care systems. The Strategic Planning to Improve Surgical, Obstetric, Anaesthesia, and Trauma Care in the Asia–Pacific Region meeting is a three-part virtual meeting series that brought together Ministries of Health, intergovernmental organisers, funders, professional associations, academic institutions, and nongovernmental organisations in the Asia–Pacific region. The meeting series took place over three virtual sessions in February and March 2021. Each session featured framing talks, panel presentations, and open discussions. Participants shared lessons about the challenges and solutions in surgical system strengthening, discussed funding opportunities, and forged strategic partnerships. Participants discussed strategies to build ongoing political momentum and mobilise funding, the implications of the COVID-19 pandemic and climate change on surgical care, the need to build a broad-based, inclusive movement, and leveraging remote technologies for workforce development and service delivery. This virtual meeting series is only the beginning of an ongoing community for knowledge sharing and strategic collaboration towards surgical system strengthening in the Asia–Pacific region.
Primary hepatic Burkitt lymphoma in a child and review of literature
Authors: Huang Zhenhui , Hu Yuanxing , He Shengye , Zeng Jiamin , Zhang Xin , Ji Cuihong , Lu Haiwu , Xue Ping , Jiang Xiaofeng 
Published: July 2023

Abstract
Background
Primary hepatic Burkitt lymphoma (PHBL) in children is an extremely rare hepatic malignancy with a dismal prognosis, unless it is detected and treated promptly.

Case summary
An 11-year-old child with abdominal pain was admitted to our hospital. No notable abnormalities were found during his physical examination or laboratory workup, but the abdominal computed tomography and magnetic resonance imaging both indicated a malignant hepatic mass measuring 9.2 × 7.1 × 7.5 cm in size. His postoperative pathology revealed an unexpected primary hepatic Burkitt lymphoma following a laparoscopic liver lobectomy. He then received rituximab and intense multi-agent chemotherapy as treatment. Despite post-chemotherapy bone marrow suppression, the patient eventually made a full recovery and had a good overall state.

Conclusion
In this study, we describe a rare case of pediatric primary hepatic Burkitt lymphoma and review the literature on clinical features, diagnosis, and treatment for primary hepatic Burkitt lymphoma in children. We stress that this diagnosis should be taken into account in the absence of other single hepatic lesions or primary tumors of hematological disorders, particularly when there is a normal AFP level.
Effect of adoption of organic farming on technical efficiency of olive-growing farms: empirical evidence from West Bank of Palestine
Authors: Kashiwagi Kenichi , Kamiyama Hajime 
Published: July 2023

AbstractOrganic farming is one of the methods that increases the value added of agricultural products in a sustainable way. This paper examines how the adoption of organic farming has impacted the technical efficiency of Palestinian olive-growing farms in the West Bank. Using cross-sectional data of olive farms in the Jenin governorate, we employ an input-oriented data envelopment analysis framework to compute radial and input use efficiencies. Considering heterogeneity in technology between organic and conventional farming, a metafrontier with a directional distance function approach was applied. As self-selection bias may exist due to the decision to adopt organic farming, we apply the endogenous switching regression method to reduce bias caused by unobserved heterogeneity. Results suggest that organic farms in Jenin are not less efficient than conventional farms. Their organic farming method improves input use efficiency with respect to labor and cost relative to conventional farming. While organic farming is commonly considered to be less efficient and more costly, our findings from Jenin imply that it is, in fact, a more efficient method. We suggest that promoting organic olive farming could offer an effective strategy for small farms to add value, despite the severe geopolitical constraints of farming in the West Bank.
Evaluation of a prison violence prevention program: impacts on violent and non-violent prison infractions
Authors: Remch Molly , Swink Gregory , Mautz Charles , Austin Anna E. , Naumann Rebecca B. 
Published: July 2023

Abstract
Background
Individuals who commit acts of violence in prisons are often placed in highly controlled environments called restrictive housing (i.e., solitary confinement), which can have severe physical and mental health consequences and does not reduce violence. As such, North Carolina prisons have introduced the rehabilitative diversion unit (RDU) to reduce the use of restrictive housing and reduce violence in prison.

Methods
We evaluated the effect of the RDU on prison infractions. We compared rates of infractions by type (including violent infractions) among men enrolled in the RDU and men who were eligible for the RDU but placed in restrictive housing for control purposes (RHCP). We also evaluated sustained program impacts by comparing the hazard of first infraction among these same two groups of men after program completion, when they had returned to the general prison population. Finally, we compared the hazard of first promotion to a less restrictive custody level (medium custody) when these men had returned to the general prison population.

Results
The primary analytic cohort was made up of 3128 men contributing 897,822 person-days. Adjusted rates of violent infractions were lower in the RDU than in RHCP (adjusted rate ratio: 0.6; 95% CI: 0.4, 1.1). All other categories of infractions, including drug-related infractions, occurred at higher rates during RDU, as compared to RHCP. In analyses of sustained program impacts, for most categories of infractions, there were no differences in the hazard of first infraction post-RDU and post-RHCP. However, the hazard of violent infraction post-RDU was higher (adjusted hazard ratio: 2.1; 95% CI: 1.1, 4.0) than post-RHCP. The hazard of promotion to a less restrictive custody level was higher post-RDU (adjusted hazard ratio: 17.4; 95% CI: 7.2, 42.2) than post-RHCP.

Conclusions
We found the RDU program may be effective in reducing violence for men enrolled in the program, but that these benefits were not sustained. Continued programming may be a useful tool to transition men from the programmatically intensive environment of the RDU to the general prison population. Additionally, we recommend the expansion of evidence-based treatment for substance use disorder.
Sustainable production of bacterioruberin carotenoid and its derivatives from Arthrobacter agilis NP20 on whey-based medium: optimization and product characterization
Authors: Noby Nehad , Khattab Sherine N. , Soliman Nadia A. 
Published: July 2023

AbstractBacterioruberin and its rare glycosylated derivatives are produced by Arthrobacter agilis as an adaptation strategy to low temperature conditions. The high antioxidant properties of bacterioruberin held great promise for different future applications like the pharmaceutical and food industries. Microbial production of bacterioruberin via a cost-effective medium will help increase its commercial availability and industrial use. The presented study aims to optimize the production of the rare C50 carotenoid bacterioruberin and its derivatives from the psychotrophic bacteria Arthrobacter agilis NP20 strain on a whey-based medium as a cost effective and readily available nutritious substrate. The aim of the study is extended to assess the efficiency of whey treatment in terms of estimating total nitrogen content in treated and untreated whey samples. The significance of medium ingredients on process outcome was first tested individually; then the most promising factors were further optimized using Box Behnken design (BBD). The produced carotenoids were characterized using UV–visible spectroscopy, FTIR spectroscopy, HPLC–DAD chromatography and HPLC-APCI-MS spectrometry. The maximum pigment yield (5.13 mg/L) was achieved after a 72-h incubation period on a core medium composed of 96% sweet whey supplemented with 0.46% MgSO4 & 0.5% yeast extract and inoculated with 6% (v/v) of a 24 h pre-culture (109 CFU/mL). The cost of the formulated medium was 1.58 $/L compared with 30.1 $/L of Bacto marine broth medium. The extracted carotenoids were identified as bacterioruberin, bis-anhydrobacteriouberin, mono anhydrobacterioruberin, and glycosylated bacterioruberin. The presented work illustrates the possibility of producing bacterioruberin carotenoid from Arthrobacter agilis through a cost-effective and eco-friendly approach using cheese whey-based medium.
Graphical Abstract
New approaches to explanting high-viscosity silicone oil in retinal surgery—polyimide cannulas vs extraction sleeves vs a luer-trocar
Authors: Hammer Maximilian , Schickhardt Sonja , Munro Donald , Scheuerle Alexander , Khoramnia Ramin , Uhl Philipp , Auffarth Gerd U. 
Published: July 2023

Abstract
Background
The removal of high-viscosity silicone oil in retinal surgery is time-intensive. In this laboratory and porcine eye study, we evaluated the efficiency of novel extraction techniques, namely shortened polyimide-cannulas, an extraction sleeve and an experimental luer-trocar system, for commercially available silicone oils.

Methods
The volume of silicone oil after a 5-min removal time was quantified. The feasibility of all studied techniques was additionally tested in vitrectomized porcine eyes. Siluron 1000, 2000, 5000 and Xtra, as well as Densiron 68 and Densiron Xtra were examined.

Results
Shortening the 23G-polyimide-cannula from 6 mm up to 1.5 mm led to a significantly higher mean aspirated volume (e.g., 1 ml/min to 1.7 ml/min for Siluron Xtra). The extraction sleeve and luer-trocar increased the flow threefold compared to the shortest polyimide cannulas at 23G (5.2 ml/min and 5.2 ml/min vs 1.7 ml/min for Siluron Xtra, respectively). The extraction sleeve and luer-trocar system reached a similar flow at 27G as the best performing 23G-cannula. Angulation and movement of the eye was possible with the 2 mm-cannula, no angulation was possible when using the extraction sleeve. Stability and control were not impaired with the experimental luer-trocar setup.

Conclusion
Shorter polyimide-cannulas and extraction sleeves increase the extraction flow but may decrease stability during surgery. The luer-trocar system facilitates rapid removal while offering great stability and control. Small 27G silicone oil removal is possible and time efficient.
A new approach to grant review assessments: score, then rank
Authors: Gallo Stephen A. , Pearce Michael , Lee Carole J. , Erosheva Elena A. 
Published: July 2023

AbstractBackgroundIn many grant review settings, proposals are selected for funding on the basis of summary statistics of review ratings. Challenges of this approach (including the presence of ties and unclear ordering of funding preference for proposals) could be mitigated if rankings such as top-k preferences or paired comparisons, which are local evaluations that enforce ordering across proposals, were also collected and incorporated in the analysis of review ratings. However, analyzing ratings and rankings simultaneously has not been done until recently. This paper describes a practical method for integrating rankings and scores and demonstrates its usefulness for making funding decisions in real-world applications.MethodsWe first present the application of our existing joint model for rankings and ratings, the Mallows-Binomial, in obtaining an integrated score for each proposal and generating the induced preference ordering. We then apply this methodology to several theoretical “toy” examples of rating and ranking data, designed to demonstrate specific properties of the model. We then describe an innovative protocol for collecting rankings of the top-six proposals as an add-on to the typical peer review scoring procedures and provide a case study using actual peer review data to exemplify the output and how the model can appropriately resolve judges’ evaluations.ResultsFor the theoretical examples, we show how the model can provide a preference order to equally rated proposals by incorporating rankings, to proposals using ratings and only partial rankings (and how they differ from a ratings-only approach) and to proposals where judges provide internally inconsistent ratings/rankings and outlier scoring. Finally, we discuss how, using real world panel data, this method can provide information about funding priority with a level of accuracy in a well-suited format for research funding decisions.ConclusionsA methodology is provided to collect and employ both rating and ranking data in peer review assessments of proposal submission quality, highlighting several advantages over methods relying on ratings alone. This method leverages information to most accurately distill reviewer opinion into a useful output to make an informed funding decision and is general enough to be applied to settings such as in the NIH panel review process.
Simplified and highly-reliable automated production of [18F]FSPG for clinical studies
Authors: Lin Mai , Ta Robert T. , Manning H. Charles 
Published: July 2023

Abstract
Background
(S)-4-(3-18F-Fluoropropyl)-L-Glutamic Acid ([18F]FSPG) is a positron emission tomography (PET) tracer that specifically targets the cystine/glutamate antiporter (xc−), which is frequently overexpressed in cancer and several neurological disorders. Pilot studies examining the dosimetry and biodistribution of [18F]FSPG in healthy volunteers and tumor detection in patients with non-small cell lung cancer, hepatocellular carcinoma, and brain tumors showed promising results. In particular, low background uptake in the brain, lung, liver, and bowel was observed that further leads to excellent imaging contrasts of [18F]FSPG PET. However, reliable production-scale cGMP-compliant automated procedures for [18F]FSPG production are still lacking to further increase the utility and clinical adoption of this radiotracer. Herein, we report the optimized automated approaches to produce [18F]FSPG through two commercially available radiosynthesizers capable of supporting centralized and large-scale production for clinical use.

Results
Starting with activity levels of 60–85 GBq, the fully-automated process to produce [18F]FSPG took less than 45 min with average radiochemical yields of 22.56 ± 0.97% and 30.82 ± 1.60% (non-decay corrected) using TRACERlab™ FXFN and FASTlab™, respectively. The radiochemical purities were > 95% and the formulated [18F]FSPG solution was determined to be sterile and colorless with the pH of 6.5–7.5. No radiolysis of the product was observed up to 8 h after final batch formulation.

Conclusions
In summary, cGMP-compliant radiosyntheses and quality control of [18F]FSPG have been established on two commercially available synthesizers leveraging high activity concentration and radiochemical purity. While the clinical trials using [18F]FSPG PET are currently underway, the automated approaches reported herein will accelerate the clinical adoption of this radiotracer and warrant centralized and large-scale production of [18F]FSPG.