bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental, Social and Governance (ESG)
Authors: Fuadah Luk Luk , Mukhtarudin Mukhtarudin , Andriana Isni , Arisman Anton 
Published: July 2023

This paper presents a Literature review of environmental, social, and governance by browsing several articles that researching the Environmental, Social and Governance (ESG). This paper reviews 25 papers published between 2021 and 2022. The stakeholder theory is widely used in research from previous studies on ESG. The 25 papers were published at the Q1 level from Scimagojr. Most studies conducted their studies by using quantitative methods that mostly used primary data, especially from the Stock Exchange. However, some studies used the qualitative methods. The dominant discussion in these articles is ESG disclosure and also ESG performance. Therefore, future research suggests focusing on topics regarding ESG disclosure or ESG Performance. The next suggestion related to the methods used for future research is a qualitative method, for example, by conducting case studies and direct interviews with sources. The final suggestion for future research that is beneficial to all stakeholders
Air Pollution in Dhaka City During Wintertime: Local vs. Transboundary Transport
Authors: Hossain M L , Rahman A K M Lutfor , Ahmmad N , Sheikh M A A , Arzina T T , Shiraj T B , Haque M M 
Published: July 2023

Air pollution is considered as the largest environmental health threat in the world. Last few years, it has also increased dramatically in different cities of Bangladesh. The air pollution of Dhaka city as well as other urban areas is very crucial for a sustainable environment. This research is mainly concentrated on studying a variety of air pollutants both qualitatively and quantitively during wintertime and checking the transboundary air pollution of Dhaka City. In the study area, air pollution was found to be at very dangerous levels. Even, air pollution has been found to be significantly higher in concentration during nighttime in Dhaka City. According to public perception and health physicians, air pollution causes many health problems such as eye irritation, headaches, COPD problem, skin cancer, hypertension, cardiovascular diseases, nausea, and asthma. Regular air quality monitoring can be effective for proper control measures of pollutants emissions that may protect the inhabitants from various illnesses. It can provide a guideline for the sustainable development of environment of city dwellers.
J. of Sci. and Tech. Res. 4(1): 81-90, 2022
Development and Testing of Waste poly(Vinyl Chloride) Based Solvent Cement for Bonding of poly(Vinyl Chloride) Pipes and Fitting
Authors: Sultana S , Sarker M K U , Eti S A 
Published: July 2023

Recyclates of waste poly(vinyl chloride) (wPVC) fill materials were used to produce solvent cement. Recyclates of wPVC were made by mechanical recycling of wPVC sheets from power plant cooling tower fill materials. Recyclates of wPVC were analyzed and used to develop solvent cement for bonding of PVC pipes and other molded objects. The formulation of wPVC based solvent cement was optimized. Virgin PVC based solvent cement was also made by applying the same optimized conditions to compare it with wPVC based solvent cement. The newly developed solvent cements were analyzed and applied to PVC pipes to find out their bonding strength compared with the bonding strength of commercial solvent cement. There were no significant differences in the results of these three different solvent cements. So recycling of wPVC into solvent cement is suitable for PVC pipes bonding applications and it has a great potential to achieve benefits for the economic and environmental conditions.
J. of Sci. and Tech. Res. 4(1): 165-172, 2022
Screening of Antimicrobial and Antioxidant Properties of Ethylenediamine Mono-dithiocarbamate to Overcome the Resistance of Microbes Against Existing Drugs
Authors: Sarker A , Ali M Irfan , Arzina T T , Hossain M Lokman , Haque M Aminul , Lutfor Rahman A K M 
Published: July 2023

Excellency of the medical treatment depends on the potentiality of drugs. The increase of the resistance of microbes against drugs is influencing this aspect. Dithiocarbamate has an application in medicine and biology. Therefore, we have synthesized ethylenediamine mono-dithiocarbamate ligand and explored its antimicrobial and antioxidant property. The ligand exhibited moderate antibacterial activity against 13 (thirteen) selected bacteria in disk diffusion method. It showed notable antifungal activity compared to the standard. Therefore, this ligand may be considered as a potential antifungal agent in antifungal drug design. The antioxidant behavior using DPPH assay revealed that this ligand has significant capability in scavenging radicals as compared to standard.
J. of Sci. and Tech. Res. 4(1): 183-190, 2022
BIMBINGAN TEKNIS PENGOLAHAN LIMBAH BIJI KARET MENJADI BAHAN BAKU ALTERNATIF PEMBUATAN KERIPIK TEMPE DI DESA JAYAKARTA BENGKULU TENGAH
Authors: Rina Elvia  , Hermansyah Amir  , Pica Lestari  
Published: July 2023

Jayakarta merupakan salah satu desa terletak di daerah kecamatan Talang Empat kabupaten Bengkulu Tengah yang memiliki komoditas utama yaitu biji karet. Selama ini biji karet dianggap sebagai limbah, sedangkan yang tumbuh akan menjadi hama bagi pohon karet dewasa. Dengan demikian, dianggap penting untuk melaksanakan program pengabdian berupa bimbingan teknis untuk mengolah limbah biji karet menjadi keripik tempe yang bernilai ekonomi terkhususnya bagi ibu-ibu rumah tangga di desa tersebut. Dalam pelaksanaan program pengabdian ini dilakukan dalam beberapa tahapan yaitu : tahap persiapan, tahap sosialisasi, tahap bimbingan teknis, tahap pembuatan, dan tahap pengemasan.. Setelah tahapan pembuatan tempe selesai, produk tersebut dijadikan dalam bentuk kemasan berupa keripik. Hal ini dilakukan untuk menjaga produk agar tahan lebih lama dalam proses pemasaran dan penjualan. Kegiatan ini diharapkan mampu memberikan keuntungan untuk petani karet dalam membersihkan hama biji karet di area perkebunan serta dapat menjadi peluang peningkatan ekonomi keluarga khususnya bagi ibu rumah tangga di desa Jayakarta.
Kata Kunci: Biji Karet, Tempe, Keripik.
LIPUS-S/B@NPs regulates the release of SDF-1 and BMP-2 to promote stem cell recruitment-osteogenesis for periodontal bone regeneration
Authors: Yan Shujin , Wang Dong , Zhang Liang , Gan Tian , Yao Huan , Zhu Hui , He Yiman , Yang Ke 
Published: July 2023

Purpose: Poly (lactic-co-glycolic acid)-based nanoparticles (PLGA NPs) have been widely used as the carrier for sustainable drug delivery. However, the drug release from the NPs was usually incomplete and uncontrollable. Herein, a low intensity pulsed ultrasound (LIPUS) assisted SDF-1/BMP-2@nanoparticles (S/B@NPs) system was fabricated to facilitate stem cell recruitment-osteogenesis for periodontal bone regeneration.Methods: In this work, S/B@NPs were prepared with double-emulsion synthesis method. Then the S/B release profile from NPs was evaluated with or without low intensity pulsed ultrasound treatment. Afterwards, the stem cell recruiting and osteoinductive capacities of LIPUS-S/B@NPs were detected with human periodontal ligament cells (hPDLCs) in vitro and in a rat periodontal bone defect model.Results: The results indicated that S/B@NPs were successfully prepared and LIPUS could effectively regulate the release of S/B and increase their final releasing amount. Moreover, LIPUS-S/B@NPs system significantly promoted hPDLCs migrating and osteogenesis in vitro and recruiting rBMSCs to the rat periodontal defect and facilitated bone regeneration in vivo.Conclusion: Our LIPUS assisted S/B@NPs system can effectively facilitate stem cell recruitment and periodontal bone regeneration. Considering its reliable safety and therapeutic effect on bone fracture, LIPUS, as an adjuvant therapy, holds great potential in the regulation of drug delivery systems for bone healing.
The combination of NDUFS1 with CD4+ T cell infiltration predicts favorable prognosis in kidney renal clear cell carcinoma
Authors: Wu Dong , He Lin , Xu Zhe , Tian Ruo-Fei , Fan Xin-Yu , Fan Jing , Ai Jie , Bian Hui-Jie , Qin Wei-Jun , Qin Jun , Li Ling 
Published: July 2023

Background: Kidney renal clear cell carcinoma (KIRC) is an immunogenic tumor, and immune infiltrates are relevant to patients’ therapeutic response and prognosis. NDUFS1, the core subunit of mitochondrial complex I, has been reported to be associated with KIRC patients’ prognosis. However, the upstream regulator for NDUFS1 and their correlations with immune infiltration remain unclear.Methods: The expression of NDUFS genes in KIRC and their influences on patients’ survival were investigated by UALCAN, ENCORI, Oncomine, TIMER as well as Kaplan-Meier Plotter. miRNAs regulating NDUFS1 were predicted and analyzed by TargetScan and ENCORI. The correlations between NDUFS1 expression and immune cell infiltration or gene marker sets of immune infiltrates were analyzed via TIMER. The overall survival in high/low NDUFS1 or hsa-miR-320b expressed KIRC patients with or without immune infiltrates were analyzed via Kaplan-Meier Plotter. The combined NDUFS1 expression and/or CD4+ T cell infiltration on KIRC patients’ overall survival were validated by multiplexed immunofluorescence (mIF) staining in tissue microarray (TMA). Furthermore, the influences of NDUFS1 expression on the chemotaxis of CD4+ T cells to KIRC cells were performed by transwell migration assays.Results: We found that the low expression of NDUFS1 mRNA and protein in KIRC was correlated with unfavorable patients’ survival and poor infiltration of CD4+ T cells. In patients with decreased CD4+ T cell infiltration whose pathological grade less than III, TMA mIF staining showed that low expression of NDUFS1 had significantly poor OS than that with high expression of NDUFS1 did. Furthermore, hsa-miR-320b, a possible negative regulator of NDUFS1, was highly expressed in KIRC. And, low NDUFS1 or high hsa-miR-320b consistently correlated to unfavorable outcomes in KIRC patients with decreased CD4+ T cell infiltration. In vitro, NDUFS1 overexpression significantly increased the chemotaxis of CD4+ T cell to KIRC cells.Conclusion: Together, NDUFS1, upregulated by decreased hsa-miR-320b expression in KIRC patients, might act as a biomarker for CD4+ T cell infiltration. And, the combination of NDUFS1 with CD4+ T cell infiltration predicts favorable prognosis in KIRC.
A rat model of metabolic syndrome-related heart failure with preserved ejection fraction phenotype: pathological alterations and possible molecular mechanisms
Authors: Shi Yujiao , Liu Chunqiu , Yang Chenguang , Qiao Wenbo , Liu Yongcheng , Liu Siyu , Dong GuoJu 
Published: July 2023

BackgroundHeart failure with preserved ejection fraction (HFpEF) represents a syndrome involving multiple pathophysiologic disorders and clinical phenotypes. This complexity makes it challenging to develop a comprehensive preclinical model, which presents an obstacle to elucidating disease mechanisms and developing new drugs. Metabolic syndrome (MetS) is a major phenotype of HFpEF. Thus, we produced a rat model of the MetS-related HFpEF phenotype and explored the molecular mechanisms underpinning the observed pathological changes.MethodsA rat model of the MetS-related HFpEF phenotype was created by feeding spontaneously hypertensive rats a high-fat-salt-sugar diet and administering streptozotocin solution intraperitoneally. Subsequently, pathological changes in the rat heart and their possible molecular mechanisms were explored.ResultsThe HFpEF rats demonstrated primary features of MetS, such as hypertension, hyperglycemia, hyperlipidemia, insulin resistance, and cardiac anomalies, such as left ventricular (LV) remodeling and diastolic impairment, and left atrial dilation. Additionally, inflammation, myocardial hypertrophy, and fibrosis were observed in LV myocardial tissue, which may be associated with diverse cellular and molecular signaling cascades. First, the inflammatory response might be related to the overexpression of inflammatory regulators (growth differentiation factor 15 (GDF-15), intercellular adhesion molecule-1 (ICAM-1), and vascular endothelial cell adhesion molecule-1 (VCAM-1)). Secondly, phosphorylated glycogen synthase kinase 3β (GSK-3β) may stimulate cardiac hypertrophy, which was regulated by activated -RAC-alpha serine/threonine-protein kinase (AKT). Finally, the transforming growth factor-β1 (TGF-β1)/Smads pathway might regulate collagen production and fibroblast activation, promoting myocardial fibrosis.ConclusionThe HFpEF rat replicates the pathology and clinical presentation of human HFpEF with MetS and may be a reliable preclinical model that helps elucidate HFpEF pathogenesis and develop effective treatment strategies.
Study on the environmental effect on human being detection using the UWB bio-radar
Authors: Ma Teng , Qi Fugui , Yu Xiao , Jiao Teng , Lv Hao , Wang Jianqi 
Published: July 2023

Objective: Non-contact penetrating detection and sensing of human beings (vital signs) through nonmetallic obstacles (ruins, wall, and smog) using the ultra-wideband (UWB) bio-radar plays a significant role in various post-disaster rescue operations in national public security events, like earthquake, building collapse, and factory explosion. In practical application scenarios, the narrowband radio frequency interference (RFI) and surrounding movement interference (SMI) are the two most common and major types of environmental interference (EI), which would cause serious effects on the penetrating detection performance of the UWB bio-radar.Methods: Therefore, through establishing a quantitative and controllable experiment system and combining a proposed quantitative evaluation method, this paper quantitatively investigates and evaluates the influencing characteristics and laws of these two interferences on human vital sign detection using the UWB bio-radar. In the quantitative experiments, two key environmental spatial parameters (interference distance and angle) of interference sources and two kinds of system parameters (main lobe width and time window) of the UWB bio-radar are considered.Results: Numerous experiments at different interference positions and corresponding statistical results demonstrated that both the RFI and SMI have a high negative correlation with the interference distance. Meanwhile, the SMI, which is highly related to the interference angle, could be screened or isolated by the detecting time window and main lobe boundary of UWB bio-radar, but the RFI could not be detected.Discussion: This study shows potential in providing transcendental knowledge and guidance for special EI suppression study, and even for the future design, manufacture, and rational use of the UWB bio-radar, facilitating improvement in the practical performance and effectiveness of the UWB bio-radar search and rescue system.
Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial
Authors: Arhab Amar , Junod Nicolas , Rossel Jean-Benoit , Giet Olivier , Sittarame Frederic , Beer Sandra , Sofra Daniela , Durrer Dominique , Delgado Humberto , Castellsague Montserrat , Laimer Markus , Puder Jardena J. 
Published: July 2023

IntroductionThe aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two variants a different exercise frequencies on the same outcomes.Research design and methodsThis was a cluster randomized-controlled assessor-blind trial conducted in 11 clinical centres in Switzerland. All participants in the clinical program with type 2 diabetes were eligible and were randomized to either standard (3 sessions/week for 12 weeks) or alternative (1 session/week for the first four weeks, then 2 sessions/week for the rest of 16 weeks) physical activity program each consisting of 36 sessions of combined aerobic and resistance exercise. Allocation was concealed by a central office unrelated to the study. The primary outcome was aerobic fitness. Secondary outcome measures included: body composition, BMI, HbA1c, muscle strength, walking speed, balance, flexibility, blood pressure, lipid profile.ResultsAll 185 patients with type 2 diabetes (mean age 59.7 +-10.2 years, 48% women) agreed to participate and were randomized in two groups: a standard group (n=88) and an alternative group (n=97)). There was an 11% increase in aerobic fitness after the program (12.5 Watts; 95% CI 6.76 to 18.25; p&lt;0.001). Significant improvements in physical fitness, body composition, and cardiometabolic parameters were observed at the end of the DIAfit program (improvements between 2-29%) except for lean body mass, triglycerides and cholesterol. No differences were observed between both programs, except for a larger weight reduction of -0.97kg (95% CI -0.04 to -1.91; p=0.04) in the standard program.ConclusionsBoth frequency variants of the nation-wide DIAfit program had beneficial effects on physical fitness, HbA1c, body composition, and blood pressure in type 2 diabetes patients and differences were negligible.Clinical trial registrationclinicaltrials.gov, identifier NCT01289587.
Taxonomic distribution of opsin families inferred from UniProt Reference Proteomes and a suite of opsin-specific hidden Markov models
Authors: Clarke Neil D. , Taylor John S. 
Published: July 2023

IntroductionOpsins are a large and sequence-diverse family of light-responsive G-protein coupled receptors involved in vision, circadian rhythm, and other processes. Numerous subfamilies have been defined based on sequence similarity, cell-type localization, signal transduction mechanism, or biological function, but there is no consensus classification system.MethodsWe used multiple hidden Markov models (HMMs) to identify opsins in the UniProt Reference Proteomes database. Opsin-specific HMMs were also used in an annotation procedure that represents sequences as a vector of HMM scores and assess the similarity of these vectors to those of annotated sequences. UniProt Reference Proteomes are built from genome sequences, allowing us to make meaningful comparisons of the number of opsins in each of the 260 species available at the time of the survey in absolute terms and relative to a larger superfamily of which opsins are a member.ResultsMore than 2,000 opsins were retrieved from 262 species (all metazoans).DiscussionMerging opsin counts into higher order taxa paints a broad view of the taxonomic distribution of opsins, and of opsin subfamilies, annotated according to three different schemes.
Impact of Plasmodium falciparum infection on DNA methylation of circulating immune cells
Authors: Almojil Dareen , Diawara Aïssatou , Soulama Issiaka , Dieng Mame Massar , Manikandan Vinu , Sermé Samuel S. , Sombié Salif , Diarra Amidou , Barry Aissata , Coulibaly Sam Aboubacar , Sirima Sodiomon B. , Idaghdour Youssef 
Published: July 2023

The regulation of immune cell responses to infection is a complex process that involves various molecular mechanisms, including epigenetic regulation. DNA methylation has been shown to play central roles in regulating gene expression and modulating cell response during infection. However, the nature and extent to which DNA methylation is involved in the host immune response in human malaria remains largely unknown. Here, we present a longitudinal study investigating the temporal dynamics of genome-wide in vivo DNA methylation profiles using 189 MethylationEPIC 850 K profiles from 66 children in Burkina Faso, West Africa, sampled three times: before infection, during symptomatic parasitemia, and after malaria treatment. The results revealed major changes in the DNA methylation profiles of children in response to both Plasmodium falciparum infection and malaria treatment, with widespread hypomethylation of CpGs upon infection (82% of 6.8 K differentially methylated regions). We document a remarkable reversal of CpG methylation profiles upon treatment to pre-infection states. These changes implicate divergence in core immune processes, including the regulation of lymphocyte, neutrophil, and myeloid leukocyte function. Integrative DNA methylation-mRNA analysis of a top differentially methylated region overlapping the pro-inflammatory gene TNF implicates DNA methylation of TNF cis regulatory elements in the molecular mechanisms of TNF regulation in human malaria. Our results highlight a central role of epigenetic regulation in mounting the host immune response to P. falciparum infection and in response to malaria treatment.
Multi-b-values-fitting readout-segmentation of long variable echo-trains diffusion-weighted imaging (RESOLVE DWI) in evaluation of disease activity and curative effect of axial spondyloarthritis (axSpA)
Authors: Chen Xianyuan , Yang Shengsheng , Lin Mingui , Gao Fei , Ma Mingping , Yu Shun 
Published: July 2023

BackgroundDisease activity is relevant to the treatment and prognosis of axSpA, and methods to quantitatively assess disease activity and efficacy of axSpA are still being explored.ObjectiveThe purpose of this study was to find an optimal quantitative indicator for evaluating disease activity and curative effect of axSpA, using multi-b-values-fitting RESOLVE DWI.MethodsThe prospective study included 106 patients divided into axSpA group (n=89) and no-axSpA group (n=17) by Assessment of Spondyloarthritis international Society (ASAS) criteria. The axSpA group were divided into active group and inactive group according to ASDAS-CRP. The active group treated with systematic tumour necrosis factor inhibitors (TNFi) was selected as treatment group (n=20). All patients underwent MRI examination of sacroiliac joints (SIJs), including RESOLVE DWI. The ADC values of subchondral bone marrow in SIJs were measured (ADC50,500 was b=50,500s/mm2 fitting, ADC50,700 was b=50,700s/mm2 fitting, and ADC50,500,700 was b=50,500,700s/mm2 fitting). By comparing the ADC values between different groups, a relatively optimal b-values-fitting sequence was obtained, further evaluating curative effect of the treatment group.ResultdThe ADC values of axSpA group, inactive group and active group SIJs were all higher than those of no-axSpA group. The ADC values of active group SIJs were all higher than those of inactive group. ADC50,500,700 had the largest AUC, relative higher sensitivity and specificity while taking account of the image quality than ADC50,700 and ADC50,500 between different groups. In the treatment group, there was no significant difference in ADC values between pre-treatment and 3 weeks, 3 weeks and 6 weeks, 6 weeks and 12 weeks (all P&gt;0.0083, Bonferroni-corrected threshold), while the decreased ADC values in the interval of 6 weeks or more were statistically significant (all P&lt;0.0083, Bonferroni-corrected threshold).ConclusionMulti-b-values-fitting (b=50,500,700s/mm2) RESOLVE DWI has a certain advantage in evaluating disease activity of axSpA. It was worth noting that short-term review (3 weeks or less) of RESOLVE DWI was unsatisfactory and review at 6 weeks or later would help to evaluate curative effect of axSpA.