bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mind-stimulating leisure activities: Prospective associations with health, wellbeing, and longevity
Authors: Weziak-Bialowolska Dorota , Bialowolski Piotr , Sacco Pier Luigi 
Published: February 2023

IntroductionThis study examines prospective associations within a 6-year perspective between three mind-stimulating leisure activities (relaxed and solitary: reading; serious and solitary: doing number and word games; serious and social: playing cards and games) and 21 outcomes in (1) physical health, (2) wellbeing, (3) daily life functioning, (4) cognitive impairment, and (5) longevity domains.MethodsData were obtained from 19,821 middle-aged and older adults from 15 countries participating in the Survey of Health, Ageing, and Retirement in Europe (SHARE). Temporal associations were obtained using generalized estimating equations. All models were controlled for prior sociodemographic, personality, lifestyle factors, health behaviors, and pre-baseline leisure activity values and all outcome variables. The Bonferroni correction was used to correct for multiple testing. E-values were calculated to examine the sensitivity of the associations to unmeasured confounding. Secondary analyses (1) under the complete case scenario, (2) after excluding respondents with health conditions, and (3) using a limited set of covariates were conducted to provide evidence for the robustness of the results.ResultsThe relaxed solitary activity of reading almost daily was prospectively associated with a lower risk of depression, experiencing pain, daily functioning limitations, cognitive impairment, lower loneliness scores, and more favorable wellbeing outcomes. Engaging in serious solitary leisure activities almost daily was prospectively associated with a lower risk of depression, feeling full of energy, and a lower risk of death by any cause. Occasionally engaging in these activities was prospectively associated with greater optimism and a lower risk of cognitive impairment. Engaging in serious social activities was prospectively associated with greater happiness, lower scores on the loneliness scale, a lower risk of Alzheimer's disease, and an increased risk of cancer. Additionally, occasionally engaging in serious social activities was associated with greater optimism and lower risk of depression, pain, and mobility limitations. These associations were independent of demographics, socioeconomic status, personality, history of diseases, and prior lifestyle. The sensitivity analyses provided substantial evidence for the robustness of these associations.DiscussionMind-engaging leisure activities can be considered a health and wellbeing resource. Practitioners may consider them tools that help middle-aged and older adults maintain their health and quality of life.
Context-specific adaptation of an eHealth-facilitated, integrated care model and tailoring its implementation strategies—A mixed-methods study as a part of the SMILe implementation science project
Authors: Valenta Sabine , Ribaut Janette , Leppla Lynn , Mielke Juliane , Teynor Alexandra , Koehly Katharina , Gerull Sabine , Grossmann Florian , Witzig-Brändli Verena , De Geest Sabina ,   on behalf of the SMILe study team
Published: February 2023

BackgroundContextually adapting complex interventions and tailoring their implementation strategies is key to a successful and sustainable implementation. While reporting guidelines for adaptations and tailoring exist, less is known about how to conduct context-specific adaptations of complex health care interventions.AimsTo describe in methodological terms how the merging of contextual analysis results (step 1) with stakeholder involvement, and considering overarching regulations (step 2) informed our adaptation of an Integrated Care Model (ICM) for SteM cell transplantatIon faciLitated by eHealth (SMILe) and the tailoring of its implementation strategies (step 3).MethodsStep 1: We used a mixed-methods design at University Hospital Basel, guided by the Basel Approach for coNtextual ANAlysis (BANANA). Step 2: Adaptations of the SMILe-ICM and tailoring of implementation strategies were discussed with an interdisciplinary team (n = 28) by considering setting specific and higher-level regulatory scenarios. Usability tests were conducted with patients (n = 5) and clinicians (n = 4). Step 3: Adaptations were conducted by merging our results from steps 1 and 2 using the Framework for Reporting Adaptations and Modifications–Enhanced (FRAME). We tailored implementation strategies according to the Expert Recommendations for Implementing Change (ERIC) compilation.ResultsStep 1: Current clinical practice was mostly acute-care-driven. Patients and clinicians valued eHealth-facilitated ICMs to support trustful patient-clinician relationships and the fitting of eHealth components to context-specific needs. Step 2: Based on information from project group meetings, adaptations were necessary on the organizational level (e.g., delivery of self-management information). Regulations informed the tailoring of SMILe-ICM`s visit timepoints and content; data protection management was adapted following Swiss regulations; and steering group meetings supported infrastructure access. The usability tests informed further adaptation of technology components. Step 3: Following FRAME and ERIC, SMILe-ICM and its implementation strategies were contextually adapted and tailored to setting-specific needs.DiscussionThis study provides a context-driven methodological approach on how to conduct intervention adaptation including the tailoring of its implementation strategies. The revealed meso-, and macro-level differences of the contextual analysis suggest a more targeted approach to enable an in-depth adaptation process. A theory-guided adaptation phase is an important first step and should be sufficiently incorporated and budgeted in implementation science projects.
Production performance, egg quality, and uterine gene expression for layers as affected by N-Carbamylglutamate supplementation
Authors: Ma Wei , Lu Yi , Wang Chunqiang 
Published: February 2023

IntroductionSupplementation of exogenous additives is a strategy to improve laying performance of layers by regulating uterine function. N-Carbamylglutamate (NCG) as an activator for endogenous arginine synthesis has the potential to regulate the laying performance of layers, but its effects have not been fully understood.MethodsThis study investigated the effects of dietary supplementation of NCG on production performance, egg quality, and uterine gene expression in layers. A total of 360 45-week-old layers with a genetic line of Jinghong No. 1 were used in this study. The experimental period was 14 weeks. All birds were divided into 4 treatments with 6 replicates per treatment and 15 birds per replicate. Dietary treatments were based on a basal diet and supplemented with 0, 0.08, 0.12, or 0.16% NCG to form C, N1, N2, and N3 groups.Results and discussionWe found that layers in group N1 had higher egg production rate than those in group C. Egg weight was significantly reduced, while eggshell thickness was significantly improved, by treatment. However, the albumen height and Haugh unit were the lowest in group N3. Based on the above results, groups C and N1 were selected for further transcriptomics analysis of uterine tissue by RNA-seq. More than 7.4 Gb clean reads and 19,882 tentative genes were obtained using the Gallus gallus genome as a reference. Transcriptomics analysis in uterus tissue revealed that 95 differentially expressed genes (DEGs) were upregulated and 127 DEGs were downregulated. Functional annotation and pathway enrichment analysis showed that DEGs in uterine tissue were mainly enriched in glutathione metabolism, cholesterol metabolism, and glycerolipid metabolism, etc. Vitamin A metabolism-related gene, RBP1, nutrient transport-related gene, ALB, protein synthesis-related gene, METTL21C, and calcium transport-related gene, RYR2, CACNB2, RAMP3, and STAC, were significantly regulated by 0.08% NCG supplementation. Therefore, we concluded that NCG supplementation at a dose of 0.08% improved production performance and egg quality of layers by regulating uterus function.
Exploring Plant Tissue Culture and Steviol Glycosides Production in Stevia rebaudiana (Bert.) Bertoni: A Review
Authors: Sharma Shilpa , Gupta Swati , Kumari Deepa , Kothari Shanker Lal , Jain Rohit , Kachhwaha Sumita 
Published: February 2023

Stevia rebaudiana (Bert.) Bertoni, commonly called “sweet leaf” is a medicinally and industrially important plant known to be rich in zero-calorie natural sweetening compound(s) known as “steviol glycosides”. However, due to its poor seed germination and slow vegetative propagation, it has become rather difficult to meet the increasing global demand for Stevia-based products. Different biotechnological approaches have been developed over the past few decades to overcome these limitations and allow for mass propagation of the plant. Several protocols for in vitro organogenesis, callogenesis, and cell suspension cultures have been developed during the past few years. Apart from this, attempts have also been made to improve the production of steviol glycosides through nutrient manipulation, the use of elicitors, hairy root cultures, genetic transformation, and metabolic pathway engineering. Therefore, this review provides an up-to-date report on the applications of various biotechnological tools for mass propagation and enhanced steviol glycoside production, along with a detailed bibliometrics analysis. This review also highlights research gaps and future considerations that could be fruitful for the scientific community to delve deeper into the various unexplored aspects of the architecture and functionality of this natural sweetening plant.
Screening of Bifidobacteria with Probiotic Potential from Healthy Infant Feces by Using 2′-Fucosyllactose
Authors: Zhang Gongsheng , Sun Hui , Xu Zihe , Tan Ze , Xiao Lihong , He Mingxue , Shang Jiaqi , Tsapieva Anna N. , Zhang Lili 
Published: February 2023

Using 2′-fucosyllactose (2′-FL) as the sole carbon source can be an efficient way to screen bifidobacteria with superior probiotic capabilities since 2′-FL is a key element in promoting the growth of intestinal bifidobacteria in newborns. This approach was used in this work to screen eight bifidobacteria strains, including one strain of Bifidobacterium longum subsp. infantis BI_Y46 and seven strains of Bifidobacterium bifidum (BB_Y10, BB_Y30, BB_Y39, BB_S40, BB_H4, BB_H5 and BB_H22). Studies on their probiotic properties showed that BI_Y46 had a unique morphology with pilus-like structure, a high resistance to bile salt stimulation and a potent inhibitory action on Escherichia coli ATCC 25922. Similarly, BB_H5 and BB_H22 produced more extracellular polysaccharides and had a higher protein content than other strains. In contrast, BB_Y22 displayed considerable auto-aggregation activity and a high resistance to bile salt stimulation. Interestingly, BB_Y39 with weak self-aggregation ability and acid resistance had very excellent bile salt tolerance, extracellular polysaccharides (EPS) production and bacteriostatic ability. In conclusion, 2′-FL was used as sole carbon source to identify eight bifidobacteria with excellent probiotic properties.
Factores neurocomunicativos en la difusión de fake news apoyadas en fotografías
Authors: Barrientos-Báez Almudena , Caldevilla-Domínguez David 
Published: February 2023

Desde el concepto de imagen de archivo, empleado por los medios para ilustrar noticias y poder aportarles un soporte visual para su empleo efectivo en entornos principalmente audiovisuales, el hecho de que imágenes implican veracidad se ha instalado en la moderna práctica de las fake news, con ejemplos continuados y constantes de afirmaciones respaldadas en redes sociales por material visual descontextualizado, antiguo, o ambas cosas. Se está llevando a cabo la creación de pruebas para convencer al usuario de realidades falsas generalmente correspondientes a necesidades de satisfacción ideológica del autor.
El objetivo principal es determinar el tipo de relación existente entre la infoxicación mediática y la comunicación en las redes sociales a partir del papel que la fotografía periodística desempeña en relación con la neurocomunicación.
La metodología se basará en un proceso inductivo-deductivo de análisis sobre el tipo de mensaje que llega a los receptores a partir de las fotografías publicadas en las redes sociales.
EVALUASI KERUSAKAN JALAN SOEKARNO HATTA LABUAN BAJO MENGGUNAKAN METODE BINA MARGA
Authors: Amrita  , Theresia MCA  , Eka Susanti  , Florianus Jemisius  
Published: February 2023

Jalan Soekarno Hatta merupakan jalan kabupaten yang sekaligus menjadi penghubung antara Kota Labuan Bajo dengan jalan Trans Flores yang merupakan jalur keluar menuju kabupaten lain di Pulau Flores. Jalan ini memegang peranan penting dalam meningkatkan pertumbuhan ekonomi karena menjadi pusat wisata kuliner, pertokoan, persewaan peralatan renang, dan berbagai aktivitas khas daerah pariwisata lainnya. Tujuan penelitian ini untuk mengetahui jenis dan tingkat kerusakan jalan dan memberikan alternatif perbaikan kerusakan jalan. Penelitian ini dilakukan pada ruas jalan Soekarno Hatta dengan panjang jalan 3500 m ,lebar 7 m dan hanya mempunyai 1 arah. Penelitian ini menggunakan metode Bina Marga No.18/T/BNKT/1990. Kerusakan yang terjadi ada 4 macam, yaitu retak, alur, lubang dan tambalan, dan kekasaran permukaan. Kerusakan yang paling dominan adalah retak-retak dan kekasaran permukaan, yang disebabkan oleh beban yang melampaui batas yang dapat dipikul oleh lapisan permukaan dan juga akibat tidak segera ditanganinya kerusakan-kerusakan lain, pengaruh cuaca (terutama hujan) dan genangan air yang mempercepat terbentuknya lubang dan berbagai kerusakan lainnya. Perbaikan kerusakan dapat dilakukan dengan penambalan lubang (patching), penambahan lapisan perkerasan (overlay), dan dengan melakukan palapisan taburan aspal pada daerah yang mengalami retak. Nilai prioritas kondisi ruas jalan ini adalah 7 sehingga dimasukkan dalam program pemeliharaan rutin.
Kata kunci : Kerusakan jalan, metode Bina Marga, Jalan Soekarno Hatta, Labuan Bajo
Pharmacological and ethnomedicinal studies of Tridax procumbens linn family (Compositeae) for anti-asthmatic activities
Authors: Patel Sapan , Tenguria R. K. , Mishra P.K. 
Published: February 2023

Tridax procumbens linn. of family- Compositeae (Asteraceae) is found plentifully in the plane areas near rivers and on marshy land. The villagers use this plant in bronchial asthma, dysentery and diarrhaea. Leaf juice is generally used to kill the bed bug in cote and wooden furniture and to protect the woods from termites etc.The whole herb juice in decoction is used by the villagers to check the hemorrhage of wounds.The detailed chemistry of the insecticidal compound was carried out, which revealed the structure of the compound. In the present communication, an effort has been made to screen the Tridax procumbens,a common plant used in folk medicines.
ANALISIS PENGARUH FASILITAS WISATA PEMANDANGAN TERHADAP KEPUASAN PENGUNJUNG (Sebuah Kajian Pada Kawasan Danau Toba Kabupaten Simalungun)
Authors: Harahap Muhammad Ade Kurnia 
Published: February 2023

The service aims to analyze the effect of a tourist destination's facilities on visitor satisfaction (satisfaction) in the Lake Toba area, Simalungun Regency. This research was conducted in several scenic tourist destination spots which the local community called Panatapan in Simalungun Regency, with a total of 313 respondents. Sources of data used are primary and secondary data obtained through questionnaires and documentation. Analysis of the data used in this study using Structural Equation Modeling (SEM) with SmartPLS 3.0 tools. The results showed the importance of developing tourist destination facilities at Kawsan Lake Toba in an effort to increase tourist visitor satisfaction.
SOSIALISASI PERANAN MAUJANA NAGORI DALAM MEMBINA HARMONISASI KEHIDUPAN MASYARAKAT YANG MULTIETNIK DI NAGORI PAMATANG SIMALUNGUN KECAMATAN SIANTAR
Authors: Purba Corry , Napitu Ulung , Matondang Marhaeni K.D , Saragih Rosmeri , Purba Erwin , Nasution Ade Mey Lisca , Saragih Desyar Tania Apelin 
Published: February 2023

This community service activity aims to describe the role of maujana nagori in fostering harmonization of multiethnic community life in Nagori Pamatang Simalungun, Siantar District. In addition to these objectives, this activity is intended to provide a deep understanding to the community so that they can create a harmonious life, even though the community living in Nagori Pamatang Simalungun is pluralist in terms of ethnicity, religion, race, and between groups. In the implementation of this socialization activity, lecture and question and answer methods were used from the speakers to all community members who attended the socialization. To optimize the socialization activities, the resource persons first consulted with the Head of Nagori so that they could invite the community and set a time for socialization so that the activities could be carried out properly. The results of the socialization activities show that the public's understanding of the importance of the role of Maujana Nagori in realizing the integration and harmonization of pluralist ethnic life in Nagori Pamatang Simalungun, Siantar District is increasing. Besides that, they are also enthusiastic about participating in the socialization and are willing to carry out constructive activities to support development and harmony of life in the midst of a multi-ethnic society
Diagnóstico ecográfico prenatal de onfalocele. Reporte de caso
Authors: Domínguez Hermenejildo Michelle , Vargas Vera Ramón , Maldonado Gómez Michael , Santillán Arias Maite , León Andreina Monserrate 
Published: February 2023

Introducción: El onfalocele es una alteración embriológica de la pared abdominal, en la cual hay falla del retorno completo de las vísceras. Presentación del caso: Se reporta el caso de paciente con embarazo de 32 semanas de gestación quien acude a control prenatal, se realiza ecografía encontrando imágenes sugestivas de gastrosquisis, por lo que es referida al tercer nivel de atención, luego de otra valoración se evidencia herniación central con la inserción del cordón umbilical en su ápice, cubierta por una membrana de peritoneo y asas intestinales en su interior compatible con onfalocele, finalmente confirmado al nacer. Conclusiones: La importancia del diagnóstico prenatal radica en detectar de forma oportuna diversas patologías y de esta manera tomar una conducta terapéutica adecuada.
Predicting the efficacy of vaginal misoprostol in the management of early pregnancy failures: A signal center study
Authors: Dasanayake D. L. W. , Ariyarathna B. , Nayake S. Walawe 
Published: February 2023

Introduction: Early pregnancy loss is a situation commonly experienced by pregnant women. Management includes expectant, medical and surgical evacuation. Medical management is effective and relatively safe option and involves use of vaginal misoprostol which was recently approved to use in Sri Lanka. Proper patient selection for the medical management will improve the success rate. Objectives: Aim is to develop a predictive model using different factors to determine the efficacy of vaginal misoprostol in medical management of early pregnancy losses. Method: This was a single center retrospective descriptive study and was carried out in Teaching Hospital, Mahamodara, Galle. Eligibility criteria was medically managed early pregnancies (<12 weeks of gestation) adherent to Health Ministry guidelines. Data was retrieved using bed head tickets and was entered to data retrieval sheet. Orange Statistics 3.26, a leading free and open-source software was used for the development, testing and validation of predictive model. One hundred thirty four cases, approximately 80% of total (5% precision level), were randomly selected using randomization to train, build, score and evaluate predictive models. The remaining 20% of the cases were used once to validate each model. Results: 167 women were recruited for the analysis. Overall success rate of vaginal misoprostol was 62.3%. Majority of women (76.6%) didn’t have significant adverse effects for misoprostol. Out of the twenty clinical and radiological parameters, only the presence of vaginal bleeding weakly associated with the success of medical management. Other factors were not statistically significant enough to develop a predictive model. Conclusion: Management of early pregnancy losses with misoprostol was relatively safe and successful in majority of patients. However, it was unable to develop a predictive model with selected factors in this study, except presence of per vaginal bleeding prior to treatment yield high info gain.
Online support for action research in a teacher education internship in rural Australia
Authors: Maxwell TW , Reid Jo-Anne , McLoughlin Catherine , Clarke Catherine , Nicholls Ruth 
Published: February 2023

The two themes of this paper are action research and online learning support in teacher internships in rural Australia. A model for the interaction of professional practise, the workplace and the university (Lee, Green and Brennan, 2000] came to inform the conceptualisation of a new final year teacher education unit which uses action research (Kemmis and McTaggart, 1988) as a learning process for interns (cf Beisser, 2000; Grundy, 1995]. This year long unit requires support in the first semester as internal students explore action research and identify potential areas for their improvement. In second semester interns (placed in 10 week internships almost exclusively in rural schools) are supported as they undertake action research to improve their practise. The unit has been piloted three times with small groups prior to full implementation in 2001. A move to online communication as the University's key support mechanism for interns at distant workplaces, and as an on campus learning strategy, was instituted in 2001. This report this paper reports upon: conceptual developments following pilots of a pre service unit in which action research during students internship is the culminating feature; online learning support for one student groups action research projects while on their internship; and early results from the action research project on online learning of neophyte teachers as internal students prior to their experience as interns.
Our move into online work, on campus and off campus in rural areas, has proved to be of particular benefit to most students. The early data vindicates this move in that (a) the students appreciated being forced to read and (b) bulletin boards can provide support for complex projects while off campus.
Kepemimpinan Pelayan Gereja yang Sesuai dengan Kepemimpinan Gembala Seperti Kepemimpinan Yesus
Authors: Budiatmaja Rudy , Lamsir Seno , Jonathans Rulli 
Published: February 2023

Mengedepankan pelayanan untuk banyak orang dalam pemenuhan dan pertumbuhan banyak orang akan membentuk citra diri yang baik dan mendapatkan kesempatan untuk dihargai sebagai pelayan yang memimpin serta melayani banyak orang di sekitarnya merupakan citra diri sebagai tipe gembala dengan kepemimpinan Kristus sebagai hamba atau pelayan yang memberikan fokus utama pada suatu aktivitas pelayanan dan bukan berdasarkan otoritas kekuasaan semata. Metode penelitian bersifat kualitatif yang menerangkan proses kepemimpinan yang terstruktur dan terencana memiliki visioner melayani banyak orang merupakan sosok pelayan yang memimpin bagikan seorang hamba atau budak yang melayani tuannya walaupun dia sendiri seorang pemimpin. Hasil penelitian menunjukkan dalam gereja, pemimpin itu sama seperti pelayan yang fokus utamanya dengan sukarela mengerjakan tugas panggilannya untuk melayani banyak orang sehingga karya Yesus Kristus di dunia dalam pemberitaan keselamatan tersebar pada dunia melalui kematian Kristus sehingga memberikan kesimpulan bahwa panggilan sebagai kepemimpinan harus dengan hati yang sukarela untuk melayani semua orang karena itu merupakan inti pokok pelayanan dalam gereja sehingga dapat dikatakan sebagai pemimpin harus melayani, artinya siap memberikan dirinya sebagai pemimpin dalam pengabdiannya pada Allah dan tidak pada manusia.