bluuebunny/crossref_metadata_2025_split huggingface dataset:
CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer
Authors: Stanland Lyla J. , Ang Hazel X. , Hoj Jacob P. , Chu Yunqiang , Tan Patrick , Wood Kris C. , Luftig Micah A. 
Published: July 2023

Abstract

PIK3CA is the second most mutated gene in cancer leading to aberrant PI3K/AKT/mTOR signaling and increased translation, proliferation, and survival. Some 4%–25% of gastric cancers display activating PIK3CA mutations, including 80% of Epstein–Barr virus–associated GCs. Small molecules, including pan-PI3K and dual PI3K/mTOR inhibitors, have shown moderate success clinically, due to broad on-target/off-tissue effects. Thus, isoform-specific and mutant selective inhibitors have been of significant interest. However, drug resistance is a problem and has affected success of new drugs. There has been a concerted effort to define mechanisms of resistance and identify potent combinations in many tumor types, though gastric cancer is comparatively understudied. In this study, we identified modulators of the response to the PI3Kα-specific inhibitor, BYL719, in PIK3CA-mutant GCs. We found that loss of NEDD9 or inhibition of BCL-XL conferred hypersensitivity to BYL719, through increased cell-cycle arrest and cell death, respectively. In addition, we discovered that loss of CBFB conferred resistance to BYL719. CBFB loss led to upregulation of the protein kinase PIM1, which can phosphorylate and activate several overlapping downstream substrates as AKT thereby maintaining pathway activity in the presence of PI3Kα inhibition. The addition of a pan-PIM inhibitor re-sensitized resistant cells to BYL719. Our data provide clear mechanistic insights into PI3Kα inhibitor response in PIK3CA-mutant gastric tumors and can inform future work as mutant-selective inhibitors are in development for diverse tumor types.

Implications:
Loss of either NEDD9 or BCL-XL confers hypersensitivity to PI3K-alpha inhibition whereas loss of CBFB confers resistance through a CBFB/PIM1 signaling axis.
Dodecafluoropentane Emulsion as a Radiosensitizer in Glioblastoma Multiforme
Authors: Lickliter Jason D. , Ruben Jeremy , Kichenadasse Ganessan , Jennens Ross , Gzell Cecelia , Mason Ralph P. , Zhou Heling , Becker Jennifer , Unger Evan , Stea Baldassarre 
Published: July 2023

Purpose:
Glioblastoma multiforme (GBM) is a hypoxic tumor resistant to radiotherapy. The purpose of this study was to assess the safety and efficacy of a novel oxygen therapeutic, dodecafluoropentane emulsion (DDFPe), in chemoradiation treatment of GBM.

Experimental Design:
In this multicenter phase Ib/II dose-escalation study, patients were administered DDFPe via intravenous infusion (0.05, 0.10, or 0.17 mL/kg) while breathing supplemental oxygen prior to each 2 Gy fraction of radiotherapy (30 fractions over 6 weeks). Patients also received standard-of-care chemotherapy [temozolomide (TMZ)]. Serial MRI scans were taken to monitor disease response. Adverse events were recorded and graded. TOLD (tissue oxygenation level–dependent) contrast MRI was obtained to validate modulation of tumor hypoxia.

Results:
Eleven patients were enrolled. DDFPe combined with radiotherapy and TMZ was well tolerated in most patients. Two patients developed delayed grade 3 radiation necrosis during dose escalation, one each at 0.1 and 0.17 mL/kg of DDFPe. Subsequent patients were treated at the 0.1 mL/kg dose level. Kaplan–Meier analysis showed a median overall survival of 19.4 months and a median progression-free survival of 9.6 months, which compares favorably to historical controls. Among 6 patients evaluable for TOLD MRI, a statistically significant reduction in tumor T1 was observed after DDFPe treatment.

Conclusions:
This trial, although small, showed that the use of DDFPe as a radiosensitizer in patients with GBM was generally safe and may provide a survival benefit. This is also the first time than TOLD MRI has shown reversal of tumor hypoxia in a clinical trial in patients. The recommended dose for phase II evaluation is 0.1 mL/kg DDFPe.
Trial Registration: NCT02189109

Significance:
This study shows that DDFPe can be safely administered to patients, and it is the first-in-human study to show reversal of hypoxia in GBM as measured by TOLD MRI. This strategy is being used in a larger phase II/III trial which will hopefully show a survival benefit by adding DDFPe during the course of fractionated radiation and concurrent chemotherapy.
Tree cover and built-up area regulate the territory size in Eurasian Magpie Pica pica in Ladakh, India
Authors: Khan Iqbal Ali , Kumar Anil , Bhatt Dinesh , Rawal Prakhar 
Published: July 2023

Eurasian Magpie Pica pica is one of the well-studied corvids, but the majority of our understanding of this species is from Europe. In India, its distribution is restricted to some valleys of Ladakh such as the northwestern part of the Indus, Nubra, Zanskar, Drass, and Suru. The present study aimed at understanding the territorial behavior of this species in small urban settlements of Ladakh region. Twenty-five pairs were studied in March 2020–April 2021. Territories were outlined for each color-banded individual, and data on habitat variables (namely built-up, agriculture, and green cover) was extracted. Generalized linear mixed models were used to study the effect of the habitat structure on territory size. The territory size (Mean ± SD) was 0.042 ± 0.025 km2, with tree cover comprising the highest proportion (24.36 ± 15.41 %) of area within territories. Built-up area was a feature of all territories, highlighting the affinity of magpies towards human presence. Presence of tree cover and built-up area significantly (~ <0.002) reduced territory size. High adaptability, foraging, and nesting opportunities, and protection from predators have been recognized as the reasons for magpies’ affinity with human habitation. Foraging opportunities are minimal outside human settlements in this region, magpies’ territories are largely shaped by the fulfilment of foraging requirements.
Expectations over Unspoken Alternatives Predict Pragmatic Inferences
Authors: Hu Jennifer , Levy Roger , Degen Judith , Schuster Sebastian 
Published: July 2023

AbstractScalar inferences (SI) are a signature example of how humans interpret language based on unspoken alternatives. While empirical studies have demonstrated that human SI rates are highly variable—both within instances of a single scale, and across different scales—there have been few proposals that quantitatively explain both cross- and within-scale variation. Furthermore, while it is generally assumed that SIs arise through reasoning about unspoken alternatives, it remains debated whether humans reason about alternatives as linguistic forms, or at the level of concepts. Here, we test a shared mechanism explaining SI rates within and across scales: context-driven expectations about the unspoken alternatives. Using neural language models to approximate human predictive distributions, we find that SI rates are captured by the expectedness of the strong scalemate as an alternative. Crucially, however, expectedness robustly predicts cross-scale variation only under a meaning-based view of alternatives. Our results suggest that pragmatic inferences arise from context-driven expectations over alternatives, and these expectations operate at the level of concepts.1
Social buffering reduces hair cortisol content in black-tailed prairie dogs during reproduction
Authors: Kusch Jillian M. , Matzke Colleen Crill , Lane Jeffrey E. 
Published: July 2023

Abstract
Stressors activate the hypothalamic-pituitary-adrenal axis which produces glucocorticoid (GC) hormones. Social buffering, the lowering of glucocorticoid secretion with increased social ties, commonly mitigates the stress response following exposure to a stressor. Black-tailed prairie dogs (Cynomys ludovicianus) are ground-dwelling sciurids that vary their social behaviour over time, and provide an exciting opportunity to investigate social buffering and GC production. We observed social behaviours and measured GC hormones in prairie dogs during the spring (reproduction) and summer. We expected social buffering would reduce GC production in the summer, following the stressors experienced during the spring. However, we found social integration and GC deposition were inversely correlated during the spring, which suggests social buffering occurs during the highly stressful period of reproduction, instead of after. Our study shows that the relationship between social behaviour and GC production is context-dependent, and social buffering may be an adaptive strategy in this colonially-living species.
Cletocamptus cubaensis n. sp. (Harpacticoida, Canthocamptidae) from Cuba with taxonomic notes on the species
Authors: Apostolov Apostol 
Published: July 2023

Abstract
A new species of harpacticoid copepod, Cletocamptus cubaensis n. sp., from a marine aquarium in Cuba, previously identified with the highly polymorphic Cletocamptus deitersi (Richard, 1897), is described herein. A revision of the Cuban material showed that, despite the morphological similarity to Cletocamptus deitersi, there are significant interspecific differences in several microcharacters that were not taken into account in the previous species determination, such as integumental sensilla and pores, and ornamentation of segments, mouthparts, swimming legs, prosome, and urosome. Additionally, some other differences were observed in the relative length and shape of the apophysis of the endopod of P3 in males, the armature complement of the second segment of endopod P2 in males (with four setae instead of three), the ornamentation and length of the caudal rami in both sexes, and the ornamentation of the anal operculum (with 8 spinules). Similarity to other species is discussed, along with brief comments on the morphological similarities and differences between the new species from Cuba and Cletocamptus nudus Gómez, 2005 recorded from Brazil and Colombia, C. schmidti Mielke, 2000 known from the Galapagos archipelago, and C. samariensis Fuentes-Reinés, Zoppi de Roa & Torres, 2015 from Colombia.
Density, structure, growth, and mortality of the population of Ocypode gaudichaudii H. Milne Edwards & Lucas, 1843 (Brachyura, Ocypodidae) in Salaverry, Peru
Authors: Hualcas Chinchayhuara Dolly S. , Mantilla Alayo Sandy J. , Culquichicón Malpica Zoila G. 
Published: July 2023

Abstract
The northern coast of Peru includes a series of dissipative desert beaches with varying levels of human impact. One endemic species to these beaches is Ocypode gaudichaudii, which has been shown to be an indicator of ecosystem disturbance. We measured population density, sex ratio, and cephalothorax length of O. gaudichaudii on three beaches near Salaverry between September 2021 and February 2022. The average population density was 0.15 burrows/m2. There was a higher proportion of males (56%); and average cephalothorax length was 28.8 ± 5.6 mm. Population, length, and sex variations during the study may be explained by behaviour of O. gaudichaudii and by temperature-dependent breeding. We also calculated the Von Bertalanffy growth parameters (, , ) and estimated the instantaneous mortality rate to be 0.84/year. These data indicate a high level of disturbance in the ecosystem, with few specimens approaching .
“I am an Image of Your Glory”: Exegesis and Theology in a Byzantine Funeral Hymn
Authors: Bucur Bogdan G. 
Published: July 2023

Abstract
Εἰκών εἰμι τῆς ἀρρήτου δόξης σου: the opening of one of the Eulogētaria hymns in the Byzantine funeral service – a highly interesting composition with roots in Late Ancient Jerusalem – invites a connection with Genesis 1:26. However, even though the allusion to the story of creation, Eden, and the Fall is undeniable, this hymn does not speak of the human being as κατ᾿εἰκόνα, but straightforwardly as the εἰκών of God’s glory. A first step in interpreting this line should therefore be the consideration of another set of biblical references, dealing not with “image” but with “glory.” We can then, as a second step, make sense of the resulting interpretation within the larger theological context of Byzantine Christomorphic anthropology, with its rich biblical and extra-biblical sources.
Tachygraphie und Tachygraphen bei Basilius von Caesarea – und darüber hinaus
Authors: Totsche Benedict 
Published: July 2023

Abstract
Starting from Letter 134 of Basil of Caesarea, the question is asked what Basil means when he uses the term ταχυγράφος. For this purpose, exemplary passages from ancient Christian and non-Christian authors are compiled. It is obvious that a shorthand system was used at that time. However, the question remains whether such a system was always used, especially since many passages do not provide a precise description of the activities of a tachygrapher. Letter 135 of Basil, on the other hand, suggests that a tachygrapher probably did not work exclusively with a shorthand system. Thus, the term ταχυγράφος has no unambiguity in its usage. In part, it is used to refer to persons who have mastered a special system of signs with the help of which they can write faster. In part, however, it is also used to refer to people who write quickly, but using the conventional alphabet.
The Didactic Nature of Gregory Nazianzen’s Poemata Arcana and the Theme of Continual, Gradated Progress
Authors: Hosle Paul K. 
Published: July 2023

Abstract
In this essay, I provide a holistic reading of Gregory Nazianzen’s Poemata Arcana, eight poems providing a coherent and systematic account of the elements of Christian theology. I explore in particular the reflexive didactic poetics of the work, arguing that one of the most recurring themes is that of continual and gradated spiritual progress toward God and that Gregory takes care to position himself as an instructor and exemplar for his readers in their own individual, gradual self-perfective journeys. Over the course of this argument, I critically reconsider prior judgements concerning the poem’s theological content (especially on the issue of apophasis and theōsis), literary technique and textual constitution.
What Can Data Tell Us about Publishing?
Authors: Kolman Michiel , Martin Rachel 
Published: July 2023

Abstract
Reliable and accurate data form the basis for driving progress and taking informed decisions. The publishing organizations – national, regional, and international – play a crucial and unique role in this, especially the International Publishers Association (IPA), which has been quite effective through its World Intellectual Property Office (WIPO) collaboration. International publishing data show the size of the market and the leading publishing nations, as well as more granular data of formats such as print versus digital. The scarcity of data from the Global South should improve over time. Moreover, we see that high-quality data can help shape policies in the publishing industry on sustainability in general and climate change in particular.
Fuzzy Delphi Method Application in Developing Methodology for Integrating Memorised Quranic Verses with Aqli Knowledge Based on Quranic Exegesis
Authors: Hilmi Ahmad Bazli Ahmad , Amir Selamat bin , Saleh Muhammad Hafiz , Sulaiman Adibah 
Published: July 2023

Abstract
Integrating naqli and aqli knowledge is an approach used in the Kolej GENIUS Insan curriculum. However, no specific model for integrating memorised Quranic verses with aqli knowledge has been highlighted for the subject of Hifz al-Quran. This study aims to outline the methodology of integrating memorised Quranic verses with aqli knowledge based on the discipline of Quranic exegesis. The Fuzzy Delphi method was used, involving twelve experts in Quranic exegesis. The findings showed that the consensus of the experts in the methodology of integrating memorised Quranic verses is the interpretation of the Quran based on the Quran, followed by the interpretation based on the opinion (al-raʾy), the hadith, the opinion of the companions, the opinion of the followers, the language, and the opinion of the previously recognised exegetes. For Quranic exegesis based on opinion (al-raʾy), there are eleven methods, ranked in order of priority.
Muqaddima of Ibn al-Ṣalāḥ and the Revival of Hadith Studies in the Mamluk Era
Authors: Noor Umar Muhammad 
Published: July 2023

Abstract
In hadith historiography, the Muqaddima (Introduction) of Ibn al-Ṣalāḥ (d. 643/1245) marked the beginning of a new era in the preservation of hadith sciences. It determined the direction of the discourse of hadith for centuries and inaugurated a cultural revolution in the Mamluk era. This article aims at explaining why and how the phenomenon occurred. Furthermore, associating the publication of the Muqaddima with the state of hadith scholarship in the 7/13 century exposes the primary factors and key people behind the spread of Muqaddima and the changes that followed. The study is qualitative in nature and used both inductive and deductive methods to analyse data acquired from various biographical dictionaries and isnād collections. It discovers that the publication of the Muqaddima has rejuvenated the study of hadith in the Mamluk era after centuries of irreversible decline through the formation of a scholarly network across the Islamic countries which sought to simplify the content of the Muqaddima for hadith students. Their works have indirectly opened the opportunity for more people to discuss hadith criticism, which was originally limited to elite scholars. Damascus and Egypt played a key role in this movement due to their strategic position as the primary center of hadith studies after the destruction of Khurasan and Baghdad by the Mongols. This finding will, to some extent, complete our understanding of the history of pre-modern hadith scholarship that is less highlighted today.
Union Strategies for the Representation of Platform Delivery Workers in Spain
Authors: Arasanz Díaz Juan , Sanz de Miguel Pablo 
Published: July 2023

Abstract
Food-delivery digital labour platforms started to operate in Spain in 2016. As in other national contexts, these platforms have misclassified workers as independent contractors rather than employees, shifting responsibilities and risks onto workers who have been forced to operate under marketized relationships lacking protection. This paper analyses trade unions practices and strategies targeted towards food-delivery platform workers (riders) in Spain. The findings are based on desk research and fieldwork consisting of semi-structured interviews with representatives from different trade unions and self-organized workers’ associations. The article shows how trade unions’ strategies resting on litigation and social dialogue ended up with the first legislation in Europe which introduced a rebuttable presumption of employment in the field of delivery platforms. At the same time, it shows the limitation of those strategies resting on institutional power resources due to the fragmentation of workers’ interests and the newly platforms’ strategies to circumvent labour law.
Society, Culture and the Speech Act of Praise – Observations from Ugandan English vis-à-vis British English
Authors: Meierkord Christiane 
Published: July 2023

Abstract
Whilst there has recently been an upsurge in studies into self-praise on social media, and despite the fact that there exists a vast amount of literature available on speech acts such as requests, apologies and compliments, praise in traditional spoken and written English has largely escaped scholarly attention. However, it seems to form a substantial part of everyday behaviour in various linguacultures, and the Ugandan ones appear to belong to these. This paper aims at describing how praise is performed in Ugandan English. Using data collected for the Uganda component of the International Corpus of English, it examines how praise is performed linguistically, in which genres praise can be found, and which functions it seems to perform in comparison to what is the case in British English data.
Improving the CFSv2 Seasonal Precipitation Forecasts across the United States by Combining Weather Regimes and Gaussian Mixture Models
Authors: Ratterman Cody , Zhang Wei , Affram Grace , Vernon Bradley 
Published: July 2023

Abstract
Although seasonal climate forecasts have major socioeconomic impacts, current forecast products, especially those for precipitation, are not yet reliable for forecasters and decision-makers. Here we developed a novel statistical–dynamical hybrid model for precipitation by applying weather regimes (WRs) and Gaussian mixture models (WR-GMM) to the National Oceanic and Atmospheric Administration’s Climate Forecast System, version 2 (CFSv2), precipitation forecasts across the continental United States. Instead of directly forecasting precipitation, WR-GMM uses observed precipitation from synoptic patterns similar to the future CFSv2 forecast. Traditionally K-means has been used to classify daily synoptic patterns into individual WRs, but the new GMM approach allows multiple WRs to be represented for the same day. The novel WR-GMM forecast model is trained on daily Climate Forecast System Reanalysis (CFSR) geopotential height and observed precipitation data during the 1981–2010 period and is verified for 2011–22. Overall, the WR-GMM method outperforms the CFSv2 ensemble forecast precipitation in terms of root-mean-square error and for Pearson correlation coefficient for lead months 1–4. Previous studies have used global climate models to forecast WRs in the Pacific Ocean and Mediterranean Sea regions, usually with an emphasis on winter months, but the WR-GMM model is the first of its kind that promises great untapped potential to improve precipitation forecasts produced by CFSv2 across the continental United States.
Carrying Death: A Qualitative Study of Women’s Bodily Perceptions After Their Baby Died in Utero
Authors: Damm Maiken F. , Jørgensen Mathilde L. , Eklund Mette V. , Hvidtjørn Dorte , Prinds Christina 
Published: July 2023

When a child dies in utero death becomes an integrated part of the mothers living body and this complex experience places a heavy existential and bodily burden on a woman experiencing stillbirth. This study uses a phenomenological approach with focus groups and individual interviews and data is discussed within a theoretical existential framework. Interviews of six women who experienced stillbirth within a range of 5 years were performed in Denmark. The participants experienced the dissonance of carrying death in their living body, expressed heightened existential considerations, a sense of transgression and of feeling trapped in an unbearable situation, and an experience of both dislocation from their body and an extreme bodily awareness. The study generates new knowledge and understanding of the how stillbirth is experienced as incomprehensible and as a violent bodily invasion of death with deep existential impact.