bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion
Authors: Sudarsanam Sriram , Guzman-Clavel Luis , Dar Nyle , Ziak Jakub , Shahid Naseer , Jin Xinyu O. , Kolodkin Alex L. 
Published: January 2025

ABSTRACTCortical connectivity is contingent on ordered emergence of neuron subtypes followed by the formation of subtype-specific axon projections. Intracortical circuits, including long-range callosal projections, are crucial for information processing, but mechanisms of intracortical axon targeting are still unclear. We find that the transcription factor Myocyte enhancer factor 2-c (Mef2c) directs the development of somatosensory cortical (S1) layer 4 and 5 pyramidal neurons during embryogenesis. During early postnatal development,Mef2cexpression shifts to layer 2/3 callosal projection neurons (L2/3 CPNs), and we find a novel function forMef2cin targeting homotopic contralateral cortical regions by S1-L2/3 CPNs. We demonstrate, using functional manipulation of EphA-EphrinA signaling inMef2c-mutant CPNs, that Mef2c downregulatesEphA6 to desensitize S1-L2/3 CPN axons to EphrinA5-repulsion at their contralateral targets. Our work uncovers dual roles forMef2cin cortical development: regulation of laminar subtype specification during embryogenesis, and axon targeting in postnatal callosal neurons.HIGHLIGHTSMef2c is required for the development of L4 and L5 neurons in the embryonic neocortexPostnatally,Mef2cis enriched in L2/3 neurons and is required for axon targetingL2/3-specificMef2cdeletion leads toEphA6upregulationMef2cdeletion in L2/3 neurons sensitizes them to EfnA5 repulsion in the contralateral cortex
LIN28-mediated gene regulatory loops synchronize developmental transitions throughout organogenesis
Authors: Thevarajan Indhujah , Osuna Maria F. , Lewey Sonia Fuentes , Sauceda Eustolia , Briseno Sayra , Griffin Caylah , Kim Bareun , Rowe R. Grant , da Rocha Edroaldo Lummertz , Osborne Jihan K. 
Published: January 2025

ABSTRACTPrecise control of the intervals between self-renewal, proliferation, and differentiation of stem/progenitor cells are coordinated by developmental regulators, comprised of both microRNAs (miRNAs) and proteins, termed heterochronic genes. These heterochronic factors make up a unique subset of evolutionarily conserved genes that regulate the developmental rate and timing of metazoans from worms to mammals. We and others have shown critical roles for the RNA-binding proteins (RBPs) Lin28 during pluripotency, reprogramming, and organogenesis. There has been much investigation into the negative feedback loop between the Lin28-RBPs and the miRNAs–Let-7during development and disease. Albeit there are fewer investigations into how positive feedback loops between mammalian Lin28-RBPs and mRNAs order mammalian spatiotemporal transitions of progenitors from specification to organogenesis. Screening for factors that activate luciferase reporters of the humanLIN28AandLIN28Bpromoters, in combination with genetic mouse models, we demonstrate positive feedforward loops between key developmental transcription factors such as B-Catenin, Sox2, Sox9, and Lin28-RBPs. Furthermore, we demonstrate heterochronic regulation of morphogenesis and ultimately differentiation is not only genetically moderated but also molecularly fine-tuned via position-dependent sequences in the 5’ and/or 3’ untranslated regions.
Determinants of resilience in local food systems: insights from world agriculture heritage sites
Authors: Vafadari Kazem , Khoshkam Mana , Yotsumoto Yukio , Bielik Peter , Ferraris Alberto 
Published: January 2025

PurposeThis study delves into the relationship between local food systems and food tourism destinations, with a specific focus on resilience. Drawing on stimulus-organism-response (S-O-R) theory, we investigate the determinants of this relationship such as destination food image (DFI), food authenticity (FA), food culture (FC), food experience (FE), food traditional value (FTV), local food products (LFPs) and resilient food system (RFS) as crucial components influencing the resilience of the food system.Design/methodology/approachThe data were collected in Oita Prefecture, Japan. The domestic, international tourists and local communities of six cities in this area were part of the surveys. A partial least squares approach (Smart-PLS 3.2.9) was used to analyse the data collected.FindingsThe results revealed that a destination’s food image, shaped by authenticity, traditional value and experiences, positively impacts the resilience of the food system, benefiting both the local community and tourists. The findings extend the literature by explaining the resilience of food systems in tourist destinations.Originality/valueThe study provides direction for policymakers and stakeholders to bolster the sustainability and resilience of local food systems as part of tourism.
Religiosity role on Islamic bank consumers’ self-esteem, mortal salience and social responsibility (CnSR): a terror management theory (TMT) perspective
Authors: Rahmawati Rahmawati , Junaidi Junaidi , Sabri Sabri , Mustika Ita , Sumardin Sumardin 
Published: January 2025

PurposeThis study explores the impact of religiosity on self-esteem and mortality salience, subsequently influencing Indonesia’s Islamic banking consumers’ social responsibility (CnSR).Design/methodology/approachIn total, 613 participants, Indonesia’s Islamic bank consumers, were recruited, and structural equation modelling (SEM) was used to examine research frameworks.FindingsThe empirical findings show that religiosity levels have a significant effect on self-esteem and mortality salience. Furthermore, mortality salience is less influential on CnSR than self-esteem. Furthermore, self-esteem and mortality salience partially bridge the relationship between religiosity and CnSR.Research limitations/implicationsFuture studies need to examine the correlation between religiosity and CnSR in other contexts and theories, such as conventional banks and companies across the globe, to provide comprehensive insights into the mindset and actions of CnSR.Practical implicationsThe recent study clarified the primary operations of Islamic bank customers in the context of business, religion and CnSR. Hence, increasing attention to customers’ social responsibility and religiosity is required from both the government and the Shariah Supervisory Board.Originality/valueThe result of the current study contributes to extending knowledge on terror management theory (TMT). In addition, it creates a fresh perspective on the factors affecting customers’ decision-making.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-02-2024-0105
Fostering altruistic prosocial tendencies in young leaders: the role of inclusive leadership and internalized values
Authors: Sholikhah Zahrotush , Nastiti Tur , Kismono Gugup 
Published: January 2025

Purpose
In the contemporary globalized era, where conscientious and inclusive leadership (IL) are increasingly valued, cultivating altruistic prosocial tendencies (APT) among future leaders becomes critical. However, a significant gap persists in understanding the optimal approach for assisting young leaders with commendable social sensitivity. This study aims to examine the connection between IL and a leader’s APT and focuses on the moderating role of internalized values (IV) among young leaders in Indonesia.

Design/methodology/approach
The research adopted a quantitative methodology, using an online survey to gather data from 12.584 participants in the “Kampus Mengajar” program. The data analysis is conducted using structural equation modeling.

Findings
The study highlights the significant association between IL and APT among leaders, emphasizing the importance of inclusive approaches in fostering prosocial behavior. Additionally, it reveals the moderating impact of IVs, indicating that leaders who embrace values promoting societal belongingness are more inclined toward altruistic actions. This nuanced insight contributes to theoretical discourse and offers practical implications for organizations and educational institutions aiming to cultivate socially conscious leadership among young leaders.

Originality/value
This study advances scholarly understanding by exploring how IL shapes APT among young leaders, integrating insights from Role Identity and Role Identity Salience theory. By examining the moderating role of IVs, the study offers nuanced insights into the conditions that enhance this relationship.
Research on the rapid diagnosis method for hunting of high-speed trains
Authors: Xie Wanru , Zhao Yixin , Zhao Gang , Yang Fei , Wei Zilong , Liu Jinzhao 
Published: January 2025

PurposeHigh-speed turnouts are more complex in structure and thus may cause abnormal vibration of high-speed train car body, affecting driving safety and passenger riding experience. Therefore, it is necessary to analyze the data characteristics of continuous hunting of high-speed trains passing through turnouts and propose a diagnostic method for engineering applications.Design/methodology/approachFirst, Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) is performed to determine the first characteristic component of the car body’s lateral acceleration. Then, the Short-Time Fourier Transform (STFT) is performed to calculate the marginal spectra. Finally, the presence of a continuous hunting problem is determined based on the results of the comparison calculations and diagnostic thresholds. To improve computational efficiency, permutation entropy (PE) is used as a fast indicator to identify turnouts with potential problems.FindingsUnder continuous hunting conditions, the PE is less than 0.90; the ratio of the maximum peak value of the signal component to the original signal peak value exceeded 0.7, and there is an energy band in the STFT time-frequency map, which corresponds to a frequency distribution range of 1–2 Hz.Originality/valueThe research results have revealed the lateral vibration characteristics of the high-speed train’s car body during continuous hunting when passing through turnouts. On this basis, an effective diagnostic method has been proposed. With a focus on practical engineering applications, a rapid screening index for identifying potential issues has been proposed, significantly enhancing the efficiency of diagnostic processes.
Probing (2D) thin-film temperature sensors: materials and fabrication perspective
Authors: Devaraj Lakshmi , S. Thaarini , R.R. Athish , Ashokan Vallimanalan 
Published: January 2025

Purpose
This study aims to provide a comprehensive overview of thin-film temperature sensors (TTS), focusing on the interplay between material properties and fabrication techniques. It evaluates the current state of the art, addressing both low- and high-temperature sensors, and explores the potential applications across various fields. The study also identifies challenges and highlights emerging trends that may shape the future of this technology.

Design/methodology/approach
This study systematically examines existing literature on TTS, categorizing the materials and fabrication methods used. The study compares the performance metrics of different materials, addresses the challenges encountered in thin-film sensors and reviews the case studies to identify successful applications. Emerging trends and future directions are also analyzed.

Findings
This study finds that TTS are integral to various advanced technologies, particularly in high-performance and specialized applications. However, their development is constrained by challenges such as limited operational range, material degradation, fabrication complexities and long-term stability. The integration of nanostructured materials and the advancement of wireless, self-powered and multifunctional sensors are poised to drive significant advancements in this field.

Originality/value
This study offers a unique perspective by bridging the gap between material science and application engineering in TTS. By critically analyzing both established and emerging technologies, the study provides valuable insights into the current state of the field and proposes pathways for future innovation in terms of interdisciplinary approaches. The focus on emerging trends and multifunctional applications sets this review apart from existing literature.
Business Model Innovation through AI Adaptation: The Role of Strategic Human Resources Management
Authors: Roy Sanjit K. , Dey Bidit L. , Brown David M. , Abid Aman , Apostolidis Chrysostomos , Christofi Michael , Tarba Shlomo 
Published: January 2025

AbstractWhile artificial intelligence (AI) requires business model innovation, it simultaneously poses persistent operational, regulatory and strategic challenges, highlighting the importance of researching AI adaptation to appropriate organizational value. AI adaptation is not monolithic, and its nature and consequent value appropriation processes may vary due to external factors and an organization's strategic approach to innovation and resource management. Accordingly, a taxonomy of AI adaptation and its link with value appropriation can yield a theoretical understanding and practical implications of why and how organizations vary in leveraging strategic human resource management to shape business innovation led by AI adaptation. In this paper, we address this issue by applying adaptive structuration theory and conducting interviews with top management personnel from 51 companies based in India. Based on our findings, we develop a novel taxonomy of AI adaptation (exploitive, exploratory, emancipatory and expedient), structured within a 2 × 2 matrix and a robust model of value appropriation within a dynamic business environment.
Managing Pregnancies of Unknown Location With the M4 Prediction Model or the NICE Algorithm: A Randomised Controlled Trial With Cross‐Sectional Diagnostic Accuracy Data
Authors: Fistouris Johan , Garbergs Helen , Bergman Katja , Bergh Christina , Strandell Annika 
Published: January 2025

ABSTRACTObjectiveTo determine the diagnostic performance and clinical utility of the M4 prediction model and the NICE algorithm managing women with pregnancy of unknown location (PUL).DesignThe study has a superiority design regarding specificity for non‐ectopic pregnancy for M4, given that the primary outcome of sensitivity for ectopic pregnancy (EP) is non‐inferior in comparison with the NICE algorithm.SettingEmergency gynaecology units in Sweden.Population595 women with PUL.MethodsParticipants were randomised (1:1) to M4 or the NICE algorithm after two serum human chorionic (hCG) levels and were categorised as high or low risk of having an EP. The diagnostic performance was evaluated on cross‐sectional data and utility by parallel groups.Main Outcome MeasuresThe proportion of EP categorised as high risk (sensitivity) and non‐ectopic pregnancies categorised as low risk (specificity). Clinical outcomes were assessed.ResultsThe sensitivity for EP was 79% (115 of 146) for M4 versus 85% (124 of 146) for the NICE algorithm, p = 0.1496 and the specificity for non‐ectopic pregnancies was 67% (300 of 449) for M4 and 74% (334 of 449) for the NICE algorithm, p = 0.0003. Clinical outcomes were similar between groups.ConclusionsThe sensitivity for EP by M4 was non‐inferior to NICE, but specificity was better for the NICE algorithm. No between group differences were observed for clinical outcomes.Trial RegistrationNCT 03461835, https://www.clinicaltrials.gov
Burdens of Tracheal, Bronchus, and Lung Cancer From 1990 to 2021 in China Compared to the Global Projection of 2036: Findings From the 2021 Global Burden of Disease Study
Authors: Chen Yuxing , Zeng Qingpeng , Li Muyu , Jin Jiahui , Zhao Jun 
Published: January 2025

ABSTRACTBackgroundTracheal, bronchial, and lung cancers (TBL cancers) pose a significant global health challenge, with rising incidence and mortality rates, particularly in China. Studies from the Global Burden of Disease (GBD), 2021, can guide screening and prevention strategies for TBL cancer. This study aims to provide a comprehensive analysis of the burden of TBL cancers in China compared to global data.MethodsWe conducted an analysis of incidence, prevalence, mortality, and disability‐adjusted life years (DALYs) from 1990 to 2021. We also performed Joinpoint regression analysis and Bayesian age‐period‐cohort (BAPC) modeling to project future trends.ResultsFrom 1990 to 2021, there was a substantial increase in TBL cancer indicators for all sexes in China, with the most significant rise observed in females. The female population showed alarming increases in age‐standardized incidence rate (ASIR) and age‐standardized prevalence rate (ASPR). While global efforts have managed to stabilize these rates, China's figures remain high, suggesting the impact of persistent risk factors such as smoking and air pollution, coupled with an aging population. Furthermore, we utilized the projection model in China to estimate that these indicators of TBL cancers in females will likely follow continuous and rapid upward trends, while the burden of TBL cancers among males is expected to have a steady trend.ConclusionAlthough global efforts have been effective in reducing the burden of TBL cancers over the past three decades, there still remains strong regional and gender heterogeneity. TBL cancers need more screening strategies and medical attention in China and in the female population.
Make an environmental impact beyond organizational boundaries through green leisure crafting of employees
Authors: Chen I‐Shuo , Wu Szu‐Hsin , Choi Jin Nam 
Published: January 2025

AbstractThis study explores the impact of green human resource management (HRM) practices on employees' pro‐environmental behaviors beyond the workplace. To explore this cross‐domain resource transfer process, we draw on self‐determination theory and propose that workplace environmental training can inspire employees to engage in green leisure crafting outside of work, thereby enhancing spontaneous personal green behaviors. In addition, building on person–environment fit theory, we further identify employees' environmental values as a positive contingency of the proposed cross‐domain resource transfer. Our empirical analysis, based on two‐wave data from 404 employees, reveals that green leisure crafting mediates the relationship between workplace environmental training and employees' green behaviors in their personal lives. These findings offer valuable insights into how modern organizations can meet the growing demand for environmental management and create social value by empowering their employees to contribute to environmental sustainability beyond organizational boundaries.
The association between depressive symptoms and lower urinary tract symptoms and impact among women: Investigating behavioural, cognitive and physiological pathways
Authors: Brady Sonya S. , Arguedas Andrés , Huling Jared D. , Hellemann Gerhard , Jacobs David R. , Lewis Cora E. , Fok Cynthia S. , Schreiner Pamela J. , Van Den Eeden Stephen K. , Markland Alayne D. 
Published: January 2025

AbstractObjectiveMechanistic studies are needed to understand why depressive symptoms are associated with poorer physical health. The objective of this study was to examine whether behavioural, cognitive and physiological factors mediated an association between depressive symptoms, measured in early adulthood, and lower urinary tract symptoms (LUTS) and their impact, a composite variable measured in mid‐life adulthood, among women in the Coronary Artery Risk Development in Young Adults study, conducted in four regions of the United States.DesignProspective cohort study.MethodsData were examined for 871 women. Depressive symptoms were measured and averaged across Years 5, 10 and 15. Year 20 health behaviour combined information about smoking, physical activity and diet. Year 25 cognitive function combined performance on different cognitive tests. Year 25 metabolic syndrome combined standard risk criteria for waist circumference, triglycerides, high‐density lipoprotein, blood pressure and glucose. A cluster analysis of urinary incontinence, other LUTS and impact data—collected two years after Year 25—was used to group women into one of four categories: no or very mild symptoms with no impact (bladder health) versus mild, moderate or severe symptoms/impact.ResultsStructural equation modelling showed a statistically significant direct path between depressive symptoms and LUTS/impact. Tests of indirect paths showed that health behaviours, cognitive function and metabolic syndrome did not mediate the association between depressive symptoms and LUTS/impact.ConclusionsDepressive symptoms in early adulthood appear to be associated with LUTS and their impact in mid‐life adulthood over and above health behaviours, cognitive function and metabolic syndrome.
The impact of host biogeography, ecology, evolutionary history, and architecture on the structure of rolled‐leaf beetle assemblages of Costa Rican Zingiberales
Authors: Chaves‐Fallas José Miguel , García‐Robledo Carlos , Carlsen Mónica M. , Vargas Orlando , Rojas‐Gómez Mónica , Marquis Robert J. 
Published: January 2025

AbstractDetermining the factors affecting the structure of insect herbivore communities is a major challenge in ecology. Previous research demonstrated that plant defenses determine plant‐herbivore associations. However, non‐defensive variables may also explain why some plant species are associated with more diverse insect herbivore assemblages than others. Neotropical rolled‐leaf beetles (Cephaloleia and Chelobasis) complete their life cycle inside the young rolled leaves of their host plants in the order Zingiberales. The diet breadth of each species in this assemblage is particularly well‐known at our study site, La Selva Biological Station in Costa Rica. This study focused on the following non‐defensive variables: host plant elevational and geographic range size, soil type, habitat, local abundance, plant size, and leaf size. Because plant characteristics among closely related plants are not independent, we analyzed these variables in a phylogenetic context. We detected a positive effect of leaf width on rolled‐leaf beetle species richness (explaining 55% of the variation), abundance (28% of the variation and 57% when habitat is included in the model), diversity (37% of the variation), and community structure (6% of the variation, and 21%–26% when taxonomic family is included in the model). Our study demonstrates that Zingiberales leaf width influences positively rolled‐leaf beetle species richness, abundance, and diversity. This effect varies among plant families. Our study shows that plant architecture plays an important role in structuring insect herbivore assemblages in Zingiberales. Our results highlight the importance of including variables beyond plant defenses to understand the ecology and evolution of plant‐herbivore interactions.