bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of immunotherapy and radioimmunotherapy targets on desmoplastic small round cell tumors
Authors: Espinosa-Cotton Madelyn , Guo Hong-Fen , Tickoo Satish K. , Cheung Nai-Kong V. 
Published: April 2023

BackgroundDevelopment of successful antibody-based immunotherapeutic and radioimmunotherapeutic strategies rely on the identification of cell surface tumor-associated antigens (TAA) with restricted expression on normal tissues. Desmoplastic small round cell tumor (DSRCT) is a rare and generally neglected malignancy that primarily affects adolescent and young adult males. New therapies capable of treating disseminated disease are needed for DSRCT, which is often widespread at diagnosis.MethodsWe used immunohistochemistry (IHC) on fresh frozen surgical specimens and patient-derived xenograft (PDX) tumors and flow cytometry on DSRCT cell lines to evaluate expression of TAAs in these tumors. In vitro cytotoxicity assays were used to evaluate the efficacy of T cell-engaging bispecific antibodies (T-BsAbs) directed at these targets. In vivo, we used an intraperitoneal xenograft mouse model of DSRCT to test T-BsAbs against several TAAs.ResultsIn DSRCT specimens we found widespread expression of B7-H3, EGFR, GD2, HER2, mesothelin, and polysialic acid, clinical targets for which specific antibody therapeutics are available. The expression of B7-H3, EGFR, HER2, and mesothelin was confirmed on the cell surface of DSRCT cell lines. In vitro cytotoxicity assays confirmed the efficacy of T cell-engaging bispecific antibodies (T-BsAbs) directed at these targets against DSRCT cells. Remarkably, a HER2xCD3 T-BsAb was capable of completely shrinking established tumors in an intraperitoneal mouse model of DSRCT.ConclusionsWe propose that these TAAs should be further investigated in preclinical models as targets for immunotherapy and radioimmunotherapy with the hope of providing a rationale to extend these therapies to patients with advanced DSRCT.
Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2
Authors: Komalasari Ni Luh Gede Yoni , Tomonobu Nahoko , Kinoshita Rie , Chen Youyi , Sakaguchi Yoshihiko , Gohara Yuma , Jiang Fan , Yamamoto Ken-ich , Murata Hitoshi , Ruma I Made Winarsa , Sumardika I Wayan , Zhou Jin , Yamauchi Akira , Kuribayashi Futoshi , Inoue Yusuke , Toyooka Shinichi , Sakaguchi Masakiyo 
Published: April 2023

BackgroundLOX family members are reported to play pivotal roles in cancer. Unlike their enzymatic activities in collagen cross-linking, their precise cancer functions are unclear. We revealed that LOXL4 is highly upregulated in breast cancer cells, and we thus sought to define an unidentified role of LOXL4 in breast cancer.MethodsWe established the MDA-MB-231 sublines MDA-MB-231-LOXL4 mutCA and -LOXL4 KO, which stably overexpress mutant LOXL4 that loses its catalytic activity and genetically ablates the intrinsic LOXL4 gene, respectively. In vitro and in vivo evaluations of these cells’ activities of cancer outgrowth were conducted by cell-based assays in cultures and an orthotopic xenograft model, respectively. The new target (s) of LOXL4 were explored by the MS/MS analytic approach.ResultsOur in vitro results revealed that both the overexpression of mutCA and the KO of LOXL4 in cells resulted in a marked reduction of cell growth and invasion. Interestingly, the lowered cellular activities observed in the engineered cells were also reflected in the mouse model. We identified a novel binding partner of LOXL4, i.e., annexin A2. LOXL4 catalyzes cell surface annexin A2 to achieve a cross-linked multimerization of annexin A2, which in turn prevents the internalization of integrin β-1, resulting in the locking of integrin β-1 on the cell surface. These events enhance the promotion of cancer cell outgrowth.ConclusionsLOXL4 has a new role in breast cancer progression that occurs via an interaction with annexin A2 and integrin β-1 on the cell surface.
Hemodynamic assessment in children after cardiac surgery: A pilot study on the value of infrared thermography
Authors: Bridier Armelle , Shcherbakova Monisha , Kawaguchi Atsushi , Poirier Nancy , Said Carla , Noumeir Rita , Jouvet Philippe 
Published: April 2023

IntroductionLow cardiac output syndrome in the postoperative period after cardiac surgery leads to an increase in tissue oxygen extraction, assessed by the oxygen extraction ratio. Measurement of the oxygen extraction ratio requires blood gases to be taken. However, the temperature of the skin and various parts of the body is a direct result of blood flow distribution and can be monitored using infrared thermography. Thus, we conducted a prospective clinical study to evaluate the correlation between the thermal gradient obtained by infrared thermography and the oxygen extraction ratio in children at risk for low cardiac output after cardiac surgery.MethodsChildren aged 0 to 18 years, having undergone cardiac surgery with cardio-pulmonary bypass in a pediatric intensive care unit were included in the study. One to 4 thermal photos were taken per patient using the FLIR One Pro thermal imaging camera. The thermal gradient between the central temperature of the inner canthus of the eye and the peripheral temperature was compared to the concomitant oxygen extraction ratio calculated from blood gases.Results41 patients were included with a median age of 6 months (IQR 3–48) with median Risk Adjustment for Congenital Heart Surgery-1 score was 2 (IQR 2–3). Eighty nine thermal photos were analyzed. The median thermal gradient was 2.5 °C (IQR 1,01–4.04). The median oxygen extraction ratio was 35% (IQR 26–42). Nine patients had an oxygen extraction ratio ≥ 50%. A significant but weak correlation was found between the thermal gradient and the oxygen extraction ratio (Spearman's test p = 0.25, p = 0.016). Thermal gradient was not correlated with any other clinical or biologic markers of low cardiac output. Only young age was an independent factor associated with an increase in the thermal gradient.ConclusionIn this pilot study, which included mainly children without severe cardiac output decrease, a significant but weak correlation between thermal gradient by infrared thermography and oxygen extraction ratio after pediatric cardiac surgery was observed. Infrared thermography is a promising non-invasive technology that could be included in multimodal monitoring of postoperative cardiac surgery patients. However, a clinical trial including more severe children is needed.
Psychometric property study of the Affective Lability Scale-short form in Chinese patients with mood disorders
Authors: Ma Mohan , Xiao Chuman , Ou Wenwen , Lv Guanyi , Huang Mei , Zhao Xiaotian , Qin Yaqi , Ju Yumeng , Zhang Yan 
Published: April 2023

IntroductionThis study aimed to investigate the psychometric properties of the Affective Lability Scale-short form (ALS-SF) among Chinese patients with mood disorders, and to compare ALS-SF subscale scores between patients with major depressive disorder (MDD) and patients with bipolar disorder (BD) depression.MethodsA total of 344 patients with mood disorders were included in our study. Participants were measured through a set of questionnaires including the Chinese version of ALS-SF, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item (GAD-7), and NEO-Five Factor Inventory (NEO-FFI). Exploratory factor analysis and confirmatory factor analysis were applied to examine the psychometric properties of ALS-SF. Besides, correlation and regression analyses were performed to explore the relationship between affective lability and depression, anxiety, and neuroticism. Independent samples t-tests were used to compare the subscale scores of ALS-SF between the MDD and BD depression groups.ResultsResults of factor analysis indicated that the model of ALS-SF was consistent with ALS-SF. The ALS-SF showed a solid validity and high internal consistency (Cronbach’s alpha = 0.861). In addition, each subscale of ALS-SF was significantly correlated with PHQ-9, GAD-7, and NEO-FFI neuroticism subscale, except for the anger subscale showed no significant correlation with PHQ-9. Besides, the depression/elation and anger factor scores in patients with BD depression were higher than in patients with MDD.ConclusionOur study suggests that the Chinese version of ALS-SF has good reliability and validity for measuring affective lability in Chinese patients with mood disorders. Assessing affective lability would assist clinicians to distinguish between MDD and BP depression and may decrease the risks of misdiagnosis.
Opposite effects of estradiol and progesterone on woman's disgust processing
Authors: Liu Mei , Zhang Xia , He Zhengming , Liang Yuan , Zou Bihong , Ma Xianjun , Gu Simeng , Wang Fushun 
Published: April 2023

BackgroundOvarian hormones play a critical role in emotion processing, which may be a major reason for the high rates of major depressive disorders in women. However, the exact roles of estradiol and progesterone in emotional processing remain unclear. To this end, we performed behavioral and rs-fMRI studies on the effects ovarian hormones on disgust emotion.MethodsIn Experiment 1, 95 Chinese female undergraduates completed the single category implicit association test (SC-IAT) and explicit measures of disgust intensity task, 32 in the menstrual phase, 30 in the follicular phase, and 33 in the luteal phase. In Experiment 2, A total of 25 healthy female undergraduates completed three sessions of the rs-fMRI. The menstrual group was scanned during cycle days 2–5, the follicular group during cycle during days 10–13, and the luteal group was scanned 3–7 days before the next menstruation.ResultsThe behavioral results showed that women during the luteal phase had higher D scores and shorter response times (RTs) to disgust stimuli compared to the menses and follicular phases. In contrast, women during the follicular phase had fewer feelings of disgust and longer RTs to pathogen stimuli compared with that during the menses and luteal phases, but this effect was moderated by the intensity of the stimuli. rs-fMRI studies showed that women during the luteal phase have higher functional connectivity in the salience network than those in the follicular phase. Compared with the menstrual phase, women have lower functional connectivity in the amygdala during the follicular phase.ConclusionIn summary, a more negative attitude to disgust stimuli and the enhanced functional connectivity of the salience network during the luteal phase may be associated with high progesterone levels, whereas lower disgust feelings and reduced functional connectivity of the amygdala during the follicular phase may be associated with high estradiol levels.
The practical utility of psychometric scales for the assessment of the impact of posttraumatic scars on mental health
Authors: Mekereș Gabriel Mihai , Buhaș Camelia Liana , Tudoran Cristina , Csep Andrei Nicolae , Tudoran Mariana , Manole Felicia , Iova Claudiu Sorin , Pop Nicolae Ovidiu , Voiţă Ioan Bogdan , Domocoș Daniela , Voiţă-Mekereş Florica 
Published: April 2023

BackgroundScars are a natural consequence of the healing process, but with an impact on the psychological and social level for the individual, which can even lead to withdrawal and social stigmatization. We aimed to analyze the psychosocial impact determined by post-traumatic scars, using psychometric scales, to assess the effectiveness of the Mekereș’ Psychosocial Internalization Scale (MPIS), and to identify relevant predictors of traumatic and surgical scar internalization.MethodsOur cohort included 293 participants, 149 women and 144 men, aged 18–64 years who were screened for scar characteristics and completed a set of psychological scales. We compared the results obtained in two subgroups: 153 subjects with posttraumatic scars and 140 with surgical scars.ResultsRelevant predictors for posttraumatic scar internalization (R2 = 0.721) are adaptation time, age of the occurrence and subjective appraisal, while for the depression, and hopelessness relevant predictors are the subjective appraisal of the scars and the posttraumatic quality of life.ConclusionThe psychological and social reporting of the aftermath of trauma, that has been followed by scar-ring, is an indicator of how a person will react and could indicate the susceptibility to psycho-pathology.
Analysis of the clinical characteristics of adult patients with hangman's fractures: A retrospective study based on multicenter clinical data
Authors: Li Guangzhou , Wang Qing 
Published: April 2023

BackgroundThere are few reports on the clinical characteristics of adult patients with hangman's fractures.MethodsThe clinical data of adult patients were collected from the hangman's fracture database of 7 medical centers. Data on patients who met the inclusion and exclusion criteria were retrospectively analyzed. Data, including gender, age, mechanism of injury, fracture classification, and treatment, were statistically analyzed.ResultsA total of 216 eligible patients (160 males and 56 females, with a mean age of 49.7 years) were selected. There was no statistically significant difference in gender distribution of different age groups. The male-to-female ratio was similar in the young group (18–44 years) and the middle-aged group (45–64 years) (both about 3:1) but decreased in the elderly group (65 years and above) (about 2:1). Overall, high-energy injury was the main mechanism of injury. There was a statistically significant difference in the percentage of patients with high-energy injury in various age groups (the highest in the young group, and the lowest in the elderly group). Overall, unstable fracture was the main fracture type, with a higher proportion in the young and elderly groups than that in the middle-aged group, but there was no statistically significant difference. From the perspective of treatment options, the percentage of patients receiving surgery was higher in the young and elderly groups than that in the middle-aged group.ConclusionHangman's fracture is predominant in males of all age groups, with high-energy injury as the main mechanism of injury. Unstable fracture is common fracture type. The percentage of patients receiving surgery in the young and elderly groups is higher than that in the middle-aged group, which may be correlated with the high incidence of unstable fracture and the life characteristics of the patients in the young and elderly age groups.
Gestión del cambio organizacional en los proyectos sociales
Authors: Campo-Vidal Jessica Marcela , Valencia-Arango Nathalia Andrea , Hernandez Hector Andres , Calderón-Sotero Jaime Hernán 
Published: April 2023

La gestión del cambio o change management se ha constituido como un recurso que apoya a las organizaciones en sus procesos de mejora, innovación, progreso, y en la superación de periodos críticos. Sin embargo, no solo las organizaciones se benefician de la gestión del cambio, sino también las instituciones públicas; esto debido a que los factores organizacionales que impulsan dichos proyectos también se encuentran en otro tipo de objetivos de cambio e innovación, como las ONG que buscan la educación igualitaria, la protección del medio ambiente, o los gobiernos que desean un mejor sistema de salud. Para el desarrollo del presente artículo se consultaron treinta (30) publicaciones, de la cuales seis (6) de revistas en español y veinticuatro (24) en inglés, integrando las descripciones conceptuales del change management y su campo de aplicación. Se encontró que la gestión del cambio en la administración pública o social busca objetivos similares a los de una organización o empresa, y el desarrollo de proyectos sociales mejora cuando su estructura de procesos y resultados se basa en el liderazgo, la comunicación, el aprendizaje, y el uso de la tecnología, ayudando a mejorar calidad de vida de las comunidades en tiempos de cambio y crisis que han tenido que pasar durante todo los acontecimientos que se han presentado como por ejemplo la reciente pandemia del COVID-19.

El presente artículo tiene como objetivo analizar las posibles similitudes entre la gestión del cambio gerencial y la gestión del cambio en los proyectos sociales, identificando conceptos administrativos que funcionan para ambos casos y que hacen de la gestión de proyectos públicos una importante herramienta en la de los gobiernos y las organizaciones que trabajan por el bienestar de las comunidades en proyectos de diferentes ámbitos, como la salud.
Calcular el radio de la tierra: emulando a Eratóstenes
Authors: Díaz-Pinzón Jorge Enrique 
Published: April 2023

Hace 2.255 años, el genial matemático, astrónomo y geógrafo griego Eratóstenes de Cirene, con palos, sombras, matemática, astronomía, e imaginación, calculó el radio de la Tierra. Por tal motivo varias ciudades del mundo, Bogotá (Colombia), Buenos Aires (Argentina), Nápoles (Italia), Úbeda (España), y Sao Paulo (Brasil), participaron del proyecto de medir el radio de la Tierra según el método de Eratóstenes en la antigüedad. Cada ciudad participante tenía que tomar unos datos de ubicación y del ángulo de la sombra que proyecta un palo vertical entre el 22 de septiembre al 4 de octubre de 2021. Una vez recolectado estos datos, se procedió a calcular la distancia media del radio de la Tierra. Los resultados obtenidos fueron: 6.205 km para Bogotá, 6.365,983 km para Buenos Aires, 6.392,121 km para Úbeda, 6.590,238 km para Nápoles y 6596,579 km para Sao Paulo. Podemos inferir del resultado de la experiencia, que ésta permitió que las ciudades participantes tuvieran una estrecha colaboración, a una prueba científica que les colocaba en contacto, a través de la Astronomía.
Women Working From Home: Higher Performance and Satisfaction or More Stress?
Authors: Wattenberg Malte , Mauritz Nina , Prädikow Lotte , Schulte Maximilian , Franken Swetlana , Armutat Sascha 
Published: April 2023

As a result of the COVID-19 pandemic, many companies and organisations have introduced or expanded remote work options, thus creating new opportunities for employees to organise their day-to-day work independently. However, several studies suggest that women tend to suffer more from the double burden, as working from home often leads to a revival of traditional gender roles. Special strategies and instruments are needed to optimise the work-life balance when working from home. The aim of this study was to identify gender-specific stress and success factors for remote work design in order to derive practical recommendations for companies, women and politics to optimise work performance, work-life balance and satisfaction in remote work. To reach this objective, an online survey in Germany (n = 247) examined the perceived work design competencies, individual agreements with managers, corporate culture, perceived collegial support and the relationship with colleagues. The respective influence of these variables on the perceived satisfaction, stress as well as work performance when working from home was examined. Using a multiple regression analysis, it was shown that the three factors workplace design competencies, individual agreements with managers and the relationship with colleagues have a significant influence on all of the examined dependent variables. This means that a strong manifestation of factors has an effect on higher satisfaction, better performance and lower level of perceived stress. Work design competence has the most significant influence on study participants here. Significant gender differences were also identified: on average, women report a higher level of satisfaction and a lower level of perceived stress. Based on the identified factors, the paper discusses specific recommendations for companies, women and politicians to help employees working from home cope better with the associated burdens.
Gender Budgeting as a Dynamic Monitoring Tool for Gender Diversity Management in Universities
Authors: Paoloni Paola , Cosentino Antonietta , Manzo Martina 
Published: April 2023

Since the early 1980s, the economic literature has recognized the importance of valorizing the differences in the corporate context as a necessity and has been fueled by studies using the term "diversity management" (Kelly & Dobbin, 1998; Keil et al., 2007). The attention placed on the issue by both public and private sector organizations has grown exponentially, embracing new contexts and also new shades of diversity (Di Santo et al., 2013). Gender is a focal element of the organizations' multiplicity, the respect for which requires equal representation of men and women in the workplace (Wawryszuk-Misztal, 2021).
The EIGE (European Institute for Gender Equality) Indicator considers different variables, among of which there are employment and education, two closely interdependent aspects which are even more prominently encountered in academia. Gender inequality in academic careers is, in fact, a global phenomenon, although the causes and consequences vary in different national contexts (Piva and Rovelli, 2022). One tool increasingly used by universities to demonstrate their commitment to pursuing gender equality is the gender budget, a document that assesses and restructures budget items considering women’s priorities and needs as well as those of men (Addabbo et al., 2015; Bilyk et al., 2021; Lucchese et al., 2022).
This paper aims to investigate whether and how gender budget can communicate the evolution of the gender diversity management approach.
The paper uses a qualitative analysis based on a single case study to answer the research question. In particular, the research is focused on gender budgeting elaborated by the oldest university in Europe: University La Sapienza, set in Rome, Italy. Sapienza University is the most prominent university in Rome and the first to implement this tool. The authors will carry out a documentary analysis of the latest gender budget (2021), comparing it with the previous ones (2016-2020), to see if it is possible to understand how Sapienza's commitment to reducing the gender gap has evolved over the years.
From a theoretical point of view, the research contributes to gender studies and non-financial reporting research, focusing on the role of clear and transparent communication in conveying the value and enhancement of diversity. From a managerial perspective, findings could increase the universities' awareness about which information the gender budget should contain to represent the organization's dynamic engagement against gender inequalities.
VI Conferencia Iberoamericana de Educación: «Declaración de Concepción»
Authors: - - 
Published: April 2023

Los Ministros y Ministras de Educación de los Países Iberoamericanos, convocados por el Ministerio de Educación de Chile y la Organización de Estados Iberoamericanos para la Educación, la Ciencia y la Cultura (OEI), nos hemos reunido en Concepción, Chile, los días 24 y 25 de septiembre de 1996, en el marco de la VI Conferencia Iberoamericana de Educación, con el fin de examinar las formas concretas en que la educación puede contribuir a consolidar la democracia y asegurar su gobernabilidad.
Nuestra propuesta es un aporte a la reflexión de nuestros Jefes de Estado y de Gobierno sobre "La Gobernabilidad para una Democracia Eficiente y Participativa", y también, una exhortación a todos los sectores del ámbito político, social y educativo para que promuevan acciones destinadas a la integración de valores democráticos en el quehacer educativo.