bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Mass Spectrometric Approaches to Tackle Challenges in Drug Discovery: The Beta-Amyloid Paradigm
Authors: Tsarbopoulos Anthony 
Published: August 2023

AbstractThe origin of many neurodegenerative disorders like Alzheimer’s Disease (AD) lies in protein processing failures, which leads to protein aggregation and accumulation as amyloid fibrils. Abnormal accumulation and aggregation of beta amyloid peptide (Aβ) eventually lead to the formation and cerebral deposition of amyloid plaques, the major pathological hallmark in AD. Aβ1-40 and Aβ1-42 are the predominant components of senile plaques formed in AD brain. The aggregation of Aβ is associated with neurodegeneration, loss of cognitive ability, and premature death. Understanding the aggregation mechanism and how to inhibit aggregate formation is therefore crucial. In light of the proposed link between oxidative stress, unregulated immune response and neurodegeneration, it is suggested that use of antioxidants may be beneficial for inhibiting Aβ fibrillogenesis. Therefore, endogenous and dietary antioxidants may offer a protective or even therapeutic alternative against amyloidosis. In this study, several compounds isolated from natural products are screened for the in vitro antiamyloidogenic activity. Novel electrospray ionization (ESI) mass spectrometry (MS)-based methodologies are employed to assess the noncovalent interactions between the Aβ and isolated components from natural products. The specificity and the stability of these noncovalent complexes were examined under different experimental conditions, whereas their relative binding strength was assessed. In addition, MS proteolytic mapping was employed to provide information on the noncovalent binding site of the bioactive molecule on the Aβ residues. This may shed some light into the mechanisms of AD pathology and provide insights into novel agents that can be employed towards prevention or even treatment of AD.
Evidence-Based Approach and Standardization of Nutraceuticals
Authors: Ochotny Misty N. , Partney Tiffany N. , Pathak Yashwant V. 
Published: August 2023

AbstractEvidence-based approach for the use and selection of nutraceuticals are presented as well as the need and challenges to creating a method for the standardization of these products. A systematic review was completed to analyze the impact of evidence-based and standardization of nutraceuticals. Evidence-based approach for nutraceuticals allow for the evaluation of these products. This process involves utilizing current and best evidence to provide individualized care for patients. Current Good Manufacturing Practices (cGMP) are regulations enforced by the FDA to ensure that drug manufacturing processes meet basic standards. Under these practices, design, monitoring, and control of manufacturing processes are regulated. These practices can track and provide tools to prevent contamination of products available to consumers. Using evidence-based approach for nutraceutical can provide healthcare providers and consumers with evidence that is patient specific, for a given intervention and desired outcome. The global market for nutraceuticals is growing and all manufacturers should comply with cGMP to ensure safe, quality products for consumers. The goal is to have all nutraceutical manufacturers worldwide embrace cGMP in order to provide consumers with safe, effective and high quality products.
Three Vessel Disease with Left Main Involvement: A Rare Manifestation of Takayasu’s Arteritis
Authors: Cuenza Lucky R. , Grayda Jose Melanio , Natividad Therese Eileen L. , Catalan Francis Carl , Razon Tamara Louise J. 
Published: August 2023

Abstract
Background
Takayasu’s arteritis is a chronic vasculitis of unknown etiology affecting large vessels. Coronary involvement is rare and myocardial infarction as a presenting symptom has only been described in case reports.

Case
We report a case of a 19 year old female diagnosed with Takayasu’s arteritis 2 years prior who came in due to chest pain and heart failure symptoms. ECG showed diffuse ischemia with ST elevation of the inferior wall. Coronary angiogram showed 3 vessel disease with left main involvement. Patient was started on high dose steroids. She then developed an acute stroke in the right posterior cerebral artery territory. She improved with Methylprednisolone pulse therapy and oral methotrexate. She was discharged on Prednisone, Methotrexate and cardiac medications and is stable on follow up.

Diagnostics
Coronary angiogram showed ostioproximal stenosis of the distal left main segment, the proximal left anterior descending artery and the proximal left circumflex artery, with the right coronary artery being totally occluded. Two dimensional echocardiogram showed an ejection fraction of 38 percent with multisegmental wall motion abnormalities. CT aortogram showed segmental narrowing of the infrarenal abdominal aorta with multiple ostioproximal stenosis of several aortic branches with extensive collateral formation. MRI showed acute infarction in the right thalamus,right medial temporal and occipital lobes and right cerebellar hemisphere and vermis

Conclusion
Takayasu’s arteritis can present with a myriad of vascular complications. The reported incidence of coronary involvement is low. This case highlights the progressive and unpredictable nature of this disease. A high index of clinical suspicion, as well as a meticulous search for the extent of disease severity allows the clinician to individualize treatment options for these patients.
Study of Correlation of Raised Crp Levels in Premenopausal and Postmenopausal Females with Hypothyroidism: Raised Crp Levels in Hypothyroidism
Authors: Varma Y. , Singh P. 
Published: August 2023

Abstract
Objective
To evaluate the correlation of raised CRP levels in premenopausal and postmenopausal females with hypothyroidism and to assess the future risk of adverse coronary events amongst them.

Methodology
This was a prospective,observational,cross-sectional,analytical study,conducted in department of cardiology and medicine,Gandhi medical college,Hamidia hospital,Bhopal from October 2013 to October 2014.Patients having hypothyroidism were subjected to this study. Age matched controls were selected randomly. Purpose of this study was explained and informed consent was obtained.

Results
Percentage of raised CRP levels in hypothyroid premenopausal females was 13.3% and in hypothyroid postmenopausal females was 24.4%. CRP levels were raised only in 3.3% of premenopausal control group and in 10% of postmenopausal control group.

Conclusion
This study showed that there is strong association of raised CRP levels with hypothyroidism in both premenopausal and postmenopausal females.
The Use of Religious Symbols in American Military Press Releases
Authors: Strahle Ann 
Published: August 2023

AbstractThis work crosses historical and critical cultural traditions and examines the status of religion in militaristic iconography and ritual and examines two main questions. What happens when collective goals are in opposition to the individual’s personal morals and ethics? Is religion used to justify military acts or attitudes by the individual in order to come to terms with their service?This project will examine press releases on the National Guard website within a three month period. The goal is to look for meaning on how they support (or not support) the use of religion by the military and the American civil religion. It is interested in the cultural work of religion, or what religion is being used to do. A comparison will also be done against press releases that concern religious issues in the military at the time of a news event.Historically, the study will trace the uses of religious practices and rituals within the military. Historians such as Jonathan Ebel, Jolyon Mitchell, and Martha Nussbaum will inform this discussion
Excessive Game-Playing and Children's Academic Performance in Port Harcourt, Nigeria
Authors: Osuagwu Titilayo 
Published: August 2023

AbstractPeople are uncertain about the role of excessive electronic game-playing on children's academic performance. It is on this premise that this study examines the effects of excessive electronic game-playing on children's academic performance in Port Harcourt. The study use survey and quasi-experiment to sample 371 students of Junior Secondary school 1-3 who are within the age brackets of 10-12. Based on the problem and objectives of the study, research questions were formulated. Research question one to know the extent of excessive game-playing among the children, while research question two sought ascertain the relationship between excessive game-playing and the academic performance of children. A null hypothesis was also formulated and tested with the Pearson Product Moment Correlation Coefficient with the level of significance tested at 0.5 level of significance. The findings showed that a proportion of the sampled population met the criterion of addiction and the majority of the children were still non-frequent gamers. The result also showed that there is a negative correlation between excessive game-playing and academic performance as the majority of the very high scorers in tests administered on the children were from the category labelled as non-frequent and low frequent gamers. The null hypothesis that said 'there is no significant relationship between extent of excessive play and academic performance was rejected, as the r-value was -0.27. Based on these findings, it was recommended that parents should monitor their children's gaming habits and that governments should control the importation of entertainment games and encourage more of educational games.
Old Practice in a New Era: Rasa as the Basis of Self-Censorship in Kompas Daily Newspaper
Authors: Wijayanto  
Published: August 2023

AbstractRasa as an element of self-censorship has never been adequately discussed within the study of Indonesian media. This paper will show that for Kompas, the biggest national newspaper in Indonesia, rasa – a central element in Javanese value, has been the basis of their self-censorship. Whereas other media use “universal” standard journalism as a basis for news selection and news production, Kompas elaborates rasa in their day-to-day practice of news making process. While presenting how rasa has been brought into practice within Kompas newsroom in the recent times, this article also argues that this kind of journalism practice can be traced back to the authoritarian period of the New Order regime. This paper argues that even though rasa is a cultural entity, underlying its manifestation into practice is actually picturing the hidden political and economic interest of Kompas journalists as minority group in Indonesia. This study bridges the gap within Indonesian media theories, which separate the political economy factors and the cultural factors as the main forces influencing media operation.
Digital divide: A Gap in interpersonal communication amongst nigerian family relationship
Authors: Ngunan Achakpa-Ikyo Patience , Regina Ogaba-Egba 
Published: August 2023

AbstractThe study Digital Divide: A Gap In Interpersonal Communication Amongst Family Relationships seeks to find out how technology has affected the willingness of family members to engage in interpersonal communication in the family. The survey research design was adopted for the research and the structured questionnaire was employed as instrument of data collection. The study found that technology has created a gap in interpersonal communication amongst family relationships and that people lose interest in communicating interpersonally with family members due to constant engagement in Information and Communication Technologies (ICTs). The study recommends that families should make concerted effort at adopting and integrating ICTs that will help enhance interpersonal communication in family relationships rather than engage with ICTS that will erode interpersonal communication amongst family relationships. Also, family centered activities that provide opportunities for family members to communicate interpersonally without the interruption or interference of any technology should be encouraged.
Urban youth in Botswana and their habitual practice of texting
Authors: Lesitaokana William O 
Published: August 2023

AbstractIn this article, I consider mobile phone consumption among urban youth in Botswana, focusing specifically on texting. During the course of this article, I demonstrate that due to the continuous need to connect with other people, as well as the inexpensive nature of texting on mobile phones, urban youth in Botswana have developed a penchant to texting on mobile phones. In particular, youth use text messaging on their devices to re-ensconce their traditional obligations of connecting with family, relatives and associates; and to link-up with their peers and other users through sms, chats, emails and online social networks. Despite this, much texting when other people are around is considered an ill-mannered activity among youth in Botswana. Overall, the findings of this study suggest that much texting, which is common among youth in Botswana is an indication that there is a close relationship between mobile phone use and the socio-economic challenges such as unemployment, poverty and rural to urban migration and that users of these devices face.
Common Perioperative Concerns in Pediatric Anesthesia: A Literature Review
Authors: Mohamed Wael Waheed 
Published: August 2023

There are several disorders that require children to be anesthetized. Sometimes, it is due to the non-cooperation of the children that requires them to be put under sedation for a procedure that is necessary for them, while at other times, it is because of any indicated surgical procedure that they have to go through, that they are put under anesthesia. However, unlike adults, children particularly the pediatric populations have particular demands and requirements that make them special candidates for receiving the required anesthesia. In children, nearly all parameters are different anatomically, physiologically, pharmacologically, and psychologically.
According to some recent studies, it has also been noted that there are significant adverse events that are linked with the induction of anesthesia in the pediatric population, that are bound to arise if care is not taken during or after the anesthesia. These problems could arise in lieu of several factors such as the choice of anesthetic, the mode of anesthesia, airway management, and the reversal of anesthesia. In all cases, it is better to avoid the risk of complications and adverse events by making sure that only the most competent and expert of all staff are involved in the anesthesia team. With proper care and management of anesthesia, it is obvious that the risk of any critical events would be comparatively much less and that the children could be operated on easily.
This review aims to deal with certain problems that arise in the background of anesthesia induction in the pediatric population. The age group that is referred to here belongs neonates to up to thirteen years of age. This review will explore the causes that result from the induction of anesthesia in such populations.
Integrated Effect of Inorganic Fertilizers and Biofertilizers on Growth and Yield of Onion (Allium cepa L.)
Authors: Singh Shivendra , Singh Peeyush Kant , Dixit Pooshpendra Singh , Singh R. B. , Pyare Ram , Bhayankar  , Ranjan A. R. 
Published: August 2023

The present investigation was carried out during winter of 2018-2019 at the Horticulture Farm of Post Graduate College, Ghazipur. The experiment was laid out in Randomized Block Design with three replications. Ten treatment combinations viz. T1-Control (100% Recommended dose of NPK), T2-75% NPK + 25% Azotobactor, T3-50% NPK + 50% Azotobactor, T4-25% NPK + 75% Azotobactor, T5-75% NPK + 25% PSB, T6-50% NPK + 50% PSB, T7- 25% NPK + 75% PSB, T8-75% NPK + 25% Azotobactor + 25% PSB, T9-50% NPK + 50% Azotobactor + 50% PSB and T10-25% NPK + 75% Azotobactor + 75% PSB. It can be concluded that the maximum growth attributes, yield parameter and yield of onion may be obtained by the application of 75% NPK + 25% Azotobactor + 25%PSBtreatment (T8), while, the treatment T7, i.e. application of 25% NPK + 75% PSB was also found to be good for growth and yield parameter of onion. It was observed that the combination of inorganic fertilizers and bio-fertilizers influence the growth and yield attributes. . Therefore, from the present investigation, it can be concluded that the onion variety N-53 performed economically well by the application of 75% NPK + 25% Azotobacter+25% PSB as compared to rest treatment.
Assessment of Influence of Seed Invigoration Treatments on Seed Germination, Seed Quality and Seedling Vigour in Fodder Maize (Zea mays L.)
Authors: A. Venkata Divya , K. Prabhavathi , T. Shashikala , P. Jagan Mohan Rao 
Published: August 2023

Poor germination in fodder crops is one of the major reasons responsible for lower than potential green forage yield of cereals. Invigoration treatments aids to promote and accelerate germination, increase the vigour of seedlings, and improve stand establishment in field, vegetable, and horticultural crops. Therefore, a study was carried out to evaluate the effect of different seed invigoration treatments on seed quality parameters viz., germination, field emergence, speed of germination, seedling length, dry weight and seedling vigour in fodder maize (Zea mays L.). The experiment was laid out in factorial completely randomized design with two factors i.e., months and treatments having 5 different seed priming treatment combinations i.e., - Priming with water for 12 hrs., - Priming with NaCl @ 4 g / litre of water for 8 hours., - Priming with Poly Ethylene Glycol solution @ 10g / litre of water for 8 hours., – Priming with GA3 @ 0.2 g / litre of water for 8 hours and - Control (unprimed seeds) and the treatments were replicated four times during Rabi, 2022-23 at the Department of Seed Science and Technology, Seed Research and Technology Centre, College of Agriculture, PJTSAU, Rajendranagar, Hyderabad, Telangana. The results obtained from this study indicate that hormonal priming with GA3 can be successfully employed to improve germination, field emergence, seedling length, dry weight, and seedling vigour in fodder maize (Zea mays L.). At the end of the study, it was observed that hormonal priming with GA3 had a significantly positive influence on mean germination per cent (90%), field emergence (87%), speed of germination (20.221%), seedling length (34.17 cm), dry weight (0.792 g), seedling vigour index-I (3082.05) and seedling vigour index-II (71.42) over the control.
Effect of Integrated Nutrient Management (INM) Practices on Growth, Yield, Economics and Soil Properties of Sweet Pepper under Open Condition at Mid Hill of Himachal Pradesh, India
Authors: Sharma Nikita , Kumar Sandeep , Yadav Deependra , Kumar Ravinder , Kumar Alok 
Published: August 2023

The present investigation entitled “Effect Of Integrated Nutrient Management (INM) Practices On Growth, Yield, Economics and Soil Properties Of Sweet Pepper Under Open Condition At Mid Hill Of Himachal Pradesh” was carried out at the Research farm of the School of Agriculture, Abhilashi University, Mandi (H.P.) during Kharif season 2022. The experiment was laid out in a randomized block design with three replications. The experiment consisted of two Bulky organic manures (FYM and vermicompost) and three inorganic sources i.e. nitrogen, phosphorus and potassium through urea, SSP an MOP respectively. The result revealed that maximum plant height (30.33 cm, 42.47 cm and 55.03 cm at 30, 45 and 60 DAT respectively), number of branches per plant (3.10, 3.43 and 4.03 at 30, 45 and 60 DAT respectively), number of leaves per plant (31.50, 32.60 and 35.03 at 30, 45 and 60 DAT respectively), plant spread (27.60 and 34.50 cm), minimum number of days taken to 50 per cent flowering (36.01), fruit length (8.03 cm), fruit diameter (6.73 cm), average fruit weight (72.07 g), maximum number of fruits per plant (13.13), maximum number of flowers per plant (14.47), number of pickings (4.33), yield per plant (1.01 kg), and fruits yield per hectare (350.34 q/ha) were recorded with the conjoint use of 50% RDF through inorganic fertilizer + 25% through FYM + 25% through vermicompost in treatment T7. This treatment also showed higher nutrient availability in the soil with the residual nutrient status of nitrogen (269.97 kg/ha), phosphorus (40.03 kg/ha) and potassium (292.33 kg/ha). Maximum gross return (₹ 595578/ha), net return (₹ 485173/ha) and maximum B: C ratio (1:5.39) was obtained in T7. Thus, application of 50% RDF through inorganic fertilizer + 25% through FYM + 25% through vermicompost was found highly beneficial for plant growth and yield of sweet pepper.
Recovery Profile of Patients Suffered with Traumatic Brains Injuries (TBI): Analysis of Case Reports
Authors: Brito Gabriel Rodrigues , Botelho Matheus de Lima , Santos Mateus Silva 
Published: August 2023

Aims: Identify the different recovery profiles of patients with traumatic brain injury (TBI).
Methodology: This study constituted a review of the literature based on the analysis of case reports published in past five years, about the profile of recovery of TBI victims on PubMed database. Manuscript in English and Portuguese language were considered. About of criteria of elegibility were priorized articles containing information about: Patient’s ages, genders, and complaints, TBI classification treatment, recovery, follow-up, and sequelae of the victims. Post-mortem studies and focused on surgical or drug treatment of the affected patient were exclused.
Results: Based on the established criteria, 08 studies were selected that contained information about the recovery of patients affected by TBI and that contemplated the established selection criteria.
Discussion: Among the results obtained, regarding the recovery profile of patients who are victims of traumatic brain injury, we list the recognition of the similarity of the pathogenic mechanisms involved in TBI, the emergence of various posterior dysfunctions, interdependence of severity, affected area and immediate intervention chosen. As well as, a variation of conducts was presented in each case, added to the significant evidence of the involvement of external factors among the prognosis on a case-by-case basis, such as: the lack of hospital structure, time until the beginning of the intervention and the presence of irreversible sequelae that they can be from a single or multiple body systems depending on the case.
Conclusion: The recovery profile of TBI patients can vary depending on the severity and extent of brain damage. These patients usually undergo a multidisciplinary rehabilitation process aimed at promoting functional recovery and improving quality of life. In the early stages of recovery, it is common for patients to have physical, cognitive, and emotional impairments. In addition, neuropsychological rehabilitation is essential to treat cognitive deficits, such as memory, attention, concentration and reasoning problems.