bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated measures of vocal interactions and engagement in inclusive preschool classrooms
Authors: Fasano Regina M. , Mitsven Samantha G. , Custode Stephanie A. , Sarker Debasish , Bulotsky‐Shearer Rebecca J. , Messinger Daniel S. , Perry Lynn K. 
Published: July 2023

AbstractClassroom engagement plays a crucial role in preschoolers' development, yet the correlates of engagement, especially among children with autism spectrum disorder (ASD) and developmental delays (DD), remains unknown. This study examines levels of engagement with classroom social partners and tasks among children in three groups ASD, DD, and typical development (TD). Here, we asked whether children's vocal interactions (vocalizations to and from peers and teachers) were associated with their classroom engagement with social partners (peers and teachers) and with tasks, and whether the association between classroom engagement and vocal interactions differed between children in the ASD group and their peers in the DD and TD groups. Automated measures of vocalizations and location quantified children's vocal interactions with peers and teachers over the course of the school year. Automated location and vocalization data were used to capture both (1) children's vocal output to specific peers and teachers, and (2) the vocal input they received from those peers and teachers. Participants were 72 3–5‐year‐olds (Mage = 48.6 months, SD = 7.0, 43% girls) and their teachers. Children in the ASD group displayed lower engagement with peers, teachers, and tasks than children in the TD group; they also showed lower engagement with peers than children in the DD group. Overall, children's own vocalizations were positively associated with engagement with social partners. Thus, although children in the ASD group tend to have lower engagement scores than children in the TD group, active participation in vocal interactions appears to support their classroom engagement with teachers and peers.
Research Collaborations With Water and Wastewater Utilities
Authors: Adams Hunter , Eyring Adam , Albert John , Hendricks Adam , Ahmad Rasheed , Wyatt Andrea , Kaymak Baris , Ikehata Keisuke , Isazadeh Siavash , Furatian Laith , Nayak Bina , Norton John , Horne Daniel 
Published: July 2023

Key TakeawaysA research program is an important opportunity for a utility to optimize processes, support permitting, and inform more cost‐effective future planning decisions.A successful utility research program should engage internal and external stakeholders, including government agencies, nonprofits, consultants, and academics.Starting with a small research project that is affordable and likely to be successful is a way to initiate a utility research program.Case studies demonstrate the value of research collaboration to shift from a reactive focus toward a preventive, risk‐based approach.
Understanding fundamental principles of enhancer biology at a model locus
Authors: Kassouf Mira , Ford Seren , Blayney Joseph , Higgs Doug 
Published: July 2023

AbstractDespite ever‐increasing accumulation of genomic data, the fundamental question of how individual genes are switched on during development, lineage‐specification and differentiation is not fully answered. It is widely accepted that this involves the interaction between at least three fundamental regulatory elements: enhancers, promoters and insulators. Enhancers contain transcription factor binding sites which are bound by transcription factors (TFs) and co‐factors expressed during cell fate decisions and maintain imposed patterns of activation, at least in part, via their epigenetic modification. This information is transferred from enhancers to their cognate promoters often by coming into close physical proximity to form a ‘transcriptional hub’ containing a high concentration of TFs and co‐factors. The mechanisms underlying these stages of transcriptional activation are not fully explained. This review focuses on how enhancers and promoters are activated during differentiation and how multiple enhancers work together to regulate gene expression. We illustrate the currently understood principles of how mammalian enhancers work and how they may be perturbed in enhanceropathies using expression of the α‐globin gene cluster during erythropoiesis, as a model.
The neuroprotective effects of Chalcones from Ashitaba on cuprizone‐induced demyelination via modulation of brain‐derived neurotrophic factor and tumor necrosis factor α
Authors: Rowhanirad Soodeh , Taherianfard Mahnaz 
Published: July 2023

AbstractIntroductionMultiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. However, the limitations of available therapeutic strategies are frustrating, both in terms of their low efficacy and multiple side effects. Previous studies showed that natural compounds such as Chalcones possess neuroprotective effects on neurodegenerative disorders. However, few studies have so far been published on the potential effects of Chalcones on treating demyelinating disease. The present study was designed to investigate the effects of Chalcones from Ashitaba (ChA) on cuprizone‐induced noxious changes in the C57BL6 mice model of MS.MethodsThe mice received normal diets (Control group: CNT), or Cuprizone‐supplemented diets either without ChA (Cuprizone group: CPZ) or with low or high (300, 600 mg/kg/day) doses of ChA (ChA‐treated groups: CPZ+ChA300/600). Brain‐derived neurotrophic factor (BDNF) and tumor necrosis factor alpha (TNFα) levels, demyelination scores in the corpus callosum (CC), and cognitive impairment were evaluated using the enzyme‐linked immunosorbent assay, histological, and Y‐maze tests, respectively.ResultsThe findings showed that ChA Co‐treatment significantly reduced the extent of demyelination in the CC and the serum and brain levels of TNFα in the ChA‐treated groups compared to the CPZ group. Besides, treatment with a higher dose of ChA significantly improved the behavioral responses and BDNF levels in the serum and brain of the CPZ+ChA600 group when compared with the CPZ group.ConclusionThe present study provided evidence for the neuroprotective effects of ChA on cuprizone‐induced demyelination and behavioral dysfunction in C57BL/6 mice, possibly by modulating TNFα secretion and BDNF expression.
Evolution of behavioral research on E‐waste management: Conceptual frameworks and future research directions
Authors: Newaz Md Shah , Appolloni Andrea 
Published: July 2023

AbstractThe rapid growth of e‐waste or waste electrical and electronic equipment (WEEE) has garnered significant attention from scholars, particularly in the behavioral domain. This study aims to conduct a comprehensive bibliometric analysis and content analysis to provide a systematic review of WEEE‐behavioral research. Firstly, a bibliometric analysis was performed using Biblioshiny (R packages) on a sample of 293 articles from Scopus and WOS databases. This part addresses the research question: A) How has the WEEE‐behavioral domain evolved over time in terms of key journals, institutions, countries, trending topics, and research streams? Secondly, a content analysis was conducted on 41 relevant articles that were able to address the following research questions: B) What are the main theories utilized and their implications in WEEE‐behavioral research? and C) what are the potential directions for future research? The findings reveal two distinct research categories, namely circular economic behavior and behavioral spillovers, with seven underlying and emerging clusters followed by corresponding research streams. Additionally, the theory of planned behavior (TPB) emerged as the core theory that was extensively utilized and expanded upon. Consequently, this study contributes to 1) understanding the evolution of the WEEE‐behavioral domain, 2) proposing an integrated theoretical framework, 3) identifying the primary research streams and their interconnections, and 4) suggesting avenues for future research, supported by a robust conceptual model for hypothesis generation.
A real‐world study of adjuvant anti‐PD ‐1 immunotherapy on stage III melanoma with BRAF, NRAS, and KIT mutations
Authors: Sun Wei , Xu Yu , Yan WangJun , Wang ChunMeng , Hu Tu , Luo ZhiGuo , Zhang XiaoWei , Liu Xin , Chen Yong 
Published: July 2023

AbstractBackgroundMelanoma frequently harbors BRAF, NRAS, or KIT mutations which influence both tumor development and treatment strategies. For example, it is still controversial whether adjuvant anti‐PD‐1 monotherapy or BRAF/MEK inhibitors may better improve the survival for resected BRAF‐mutant melanoma. Furthermore, outcomes for melanoma with NRAS and KIT mutation receiving adjuvant immunotherapy remain unclear.MethodsOne hundred seventy‐four stage III melanoma patients who underwent radical surgery in Fudan University Shanghai Cancer Center (FUSCC) during January 2017 to December 2021 were included in this real‐world study. Patients were followed up until death or May 30th, 2022. Pearson's chi‐squared test or Fisher's exact test was performed for univariable analysis of the different category groups. Log‐rank analysis was used to identify the prognostic factors for disease‐free survival (DFS).ResultsThere were 41 (23.6%) patients with BRAF mutation, 31 (17.8%) with NRAS mutation, 17 (9.8%) with KIT mutation, and 85 (48.9%) wild‐type patients without either genomic alteration of those three genes. Most ( n  = 118, 67.8%) of them were acral melanoma, while 45 (25.9%) were cutaneous subtype, and 11 were (6.3%) primary unknown. Among them, 115 (66.1%) patients received pembrolizumab or toripalimab monotherapy as adjuvant therapy; 22 (12.6%) patients received high‐dose interferon (IFN), and 37 (21.3%) patients were just for observation. There was no statistical difference in clinicopathologic factors between anti‐PD‐1 group and IFN/OBS group. Of all the enrolled patients, anti‐PD‐1 group had a better DFS than IFN/OBS group ( p  = 0.039). In anti‐PD‐1 group, patients with BRAF or NRAS mutations had poorer DFS than wild‐type group. No survival difference was found among patients harboring different gene mutations in IFN/OBS group. In wild‐type patients, anti‐PD‐1 group had a better DFS than IFN/OBS group ( p  = 0.003), while no survival benefits were found for patients with BRAF, NRAS, or KIT mutations.ConclusionAlthough anti‐PD‐1 adjuvant therapy provides a better DFS in the general population and in wild‐type patients, patients with BRAF, KIT or, especially, NRAS mutation may not benefit further from immunotherapy than conventional IFN treatment or observation.
Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion
Authors: Castillo Martín I. , Ribate Villamón E. , Muñoz Calabuig M. , Santillana Sanz G. , Taboada Such E. , Casterá Mora E. , Abinzano Calasanz M. J. , Barranco Irigoyen A. , Nieto Collado R. , Pampliega Vara M. , Blanco M. L. , de Andrés Álvarez S. , de Oteyza Pérez J. , del Castillo Bernal T. , Font Granada I. , Cayuela Jerez A. , Díez‐Campelo M. , Sánchez Abellán R. , Vercet Solano C. , Díaz Tormo M. ,   Grupo Español de Síndromes Mielodisplásicos (GESMD)
Published: July 2023

AbstractBackgroundIn myelodysplastic neoplasms (MDS), the 20q deletion [del(20q)] is a recurrent chromosomal abnormality that it has a high co‐occurrence with U2AF1 mutations. Nevertheless, the prognostic impact of U2AF1 in these MDS patients is uncertain and the possible clinical and/or prognostic differences between the mutation type and the mutational burden are also unknown.MethodsOur study analyzes different molecular variables in 100 MDS patients with isolated del(20q).Results & ConclusionsWe describe the high incidence and negative prognostic impact of U2AF1 mutations and other alterations such as in ASXL1 gene to identify prognostic markers that would benefit patients to receive earlier treatment.
Primary resistance to nivolumab plus ipilimumab therapy in patients with metastatic renal cell carcinoma
Authors: Numakura Kazuyuki , Sekine Yuya , Hatakeyama Shingo , Muto Yumina , Sobu Ryuta , Kobayashi Mizuki , Sasagawa Hajime , Kashima Soki , Yamamto Ryohei , Nara Taketoshi , Akashi Hideo , Tabata Ryuji , Sato Satoshi , Saito Mitsuru , Narita Shintaro , Ohyama Chikara , Habuchi Tomonori 
Published: July 2023

AbstractBackgroundNivolumab plus ipilimumab (NIVO+IPI) is the first‐line treatment for patients with metastatic renal cell carcinoma (mRCC). Approximately 40% of patients achieve a durable response; however, 20% develop primary resistant disease (PRD) to NIVO+IPI, about which little is known in patients with mRCC. Therefore, this investigation aimed to evaluate the clinical implication of PRD in patients with mRCC to select better candidates in whom NIVO+IPI can be initiated as first‐line therapy.MethodsThis multi‐institutional retrospective cohort study used data collected between August 2015 and January 2023. In total, 120 patients with mRCC treated with NIVO+IPI were eligible. Associations between immune‐related adverse events and progression‐free survival, overall survival (OS), and objective response rate were analyzed. The relationship between other clinical factors and outcomes was also evaluated.ResultsThe median observation period was 16 months (interquartile range, 5–27). The median age at NIVO+IPI initiation was 68 years in the male‐dominant population (n = 86, 71.7%), and most patients had clear cell histology (n = 104, 86.7%). PRD was recorded in 26 (23.4%) of 111 investigated patients during NIVO+IPI therapy. Patients who experienced PRD showed worse OS (hazard ratio: 4.525, 95% confidence interval [CI]: 2.315–8.850, p < 0.001). Multivariable analysis showed that lymph node metastasis (LNM) (odds ratio: 4.274, 95% CI: 1.075–16.949, p = 0.039) was an independent risk factor for PRD.ConclusionsPRD was strongly correlated with worse survival rates. LNM was independently associated with PRD in patients with mRCC receiving NIVO+IPI as first‐line therapy and might indicate that a candidate will not benefit from NIVO+IPI.
Flattery will get you somewhere, sometimes? The effect of flattery and hotel segments on a hotel guests' green behavior
Authors: Kang Eun Yeon , Atkinson Lucy , Sung Yoon Hi 
Published: July 2023

AbstractConsidering the importance of the hotel guests' behavioral support for the hotels' green corporate social responsibility (CSR), this research examined the persuasive power of flattery in promoting guests' green behaviors. Study 1 revealed that a flattery message significantly increased the hotel guests' towel reuse intentions during their stay and this effect was mediated by their perceptions of the hotel's CSR motives. Study 2 further showed that a feeling of guilt served as another key mediator in the relationship between a flattery message and the guests' responses (i.e., perceived CSR motives, hotel image, attitudes toward a hotel, towel reuse intentions), which was moderated by hotel segment (economy vs. mid‐priced vs. luxury). This research provides meaningful insights into the understanding of the consumers' pro‐environmental decisions in the service consumption context and explains the underlying cognitive process. Moreover, this research offers an empirical message strategy by hotel segments to effectively promote the hotel guests' green behavior and achieve successful marketing outcomes.
Rare root canal morphology of maxillary second molars: A report of three cases
Authors: Nagahara Takayoshi , Takeda Katsuhiro , Wada Keinoshin , Naruse Tomoya , Shiba Hideki 
Published: July 2023

Key Clinical MessageEndodontists should be aware that some maxillary second molars can have more than three roots. If any unusual anatomical features are detected during dental radiography or endodontic procedures, it is necessary to conduct cone‐beam computed tomography (CBCT) scanning to prevent procedural mishaps.AbstractCBCT can provide three‐dimensional reconstructed images of the root canal system. With the help of CBCT, variations in tooth root number and root canal morphology, such as extra canals, apical ramifications, apical deltas, and lateral canals, can be identified. Knowledge of the variations is very important for the success of endodontic treatment. This report suggests that endodontists must not assume that a MSM has only three tooth roots, which is the most prevalent number.
A rare case report of diverticulum of the buccal mucosa
Authors: Koike Kazushige , Mori Hinako , Ogi Kazuhiro , Jin Makiya , Ohwada Satoshi , Iwamoto Takahiro , Sugita Shintaro , Hasegawa Tadashi , Miyazaki Akihiro 
Published: July 2023

Key Clinical MessageWe report a case of diverticulum of the buccal mucosa. A 56‐year‐old man had a small pouch‐shaped lesion behind the parotid papilla that caused pain and food impaction. After resection, the lesion was histopathologically diagnosed as diverticulum without buccal muscle tear. There has been no recurrence during 1 year postoperatively.
Effect of Surface Temperature on the Distribution and Reactivity of Rh Active Sites for CO Oxidation
Authors: Çınar Volkan , Dannar Audrey , Hunt Adrian , Schilling Alex C. , Wang Yicheng , Hannagan Ryan T. , Korotkin Jessica , Waluyo Iradwikanari , Sykes E. Charles H. 
Published: July 2023

AbstractSingle‐atom catalysts are a fast‐emerging area in which late‐transition metal atoms are supported on oxides, metals, and carbonaceous supports. They show great promise for selective chemical reactions due to their well‐defined active sites, and significantly reduce precious metal loading. However, oxide‐supported single‐atom catalysts have drawbacks such as deactivation due to sintering, and there are on‐going debates about the exact nature of the active sites. Herein we report a model system where the surface temperature during Rh deposition on a copper oxide support dictates the Rh size distribution. Our temperature‐programmed desorption experiments reveal that Rh clusters perform CO oxidation at lower temperature than single atoms, and isotopic labelling demonstrates differences in the mechanism in that the C−O bond is broken and reformed on clusters, as opposed to a pure Mars van Krevelen mechanism for CO oxidation at the single‐atom Rh sites. We further examine the cluster size distributions with scanning tunneling microscopy and X‐ray photoelectron spectroscopy which confirm the presence of both clusters and single atoms for the lower temperature deposition and only single atoms for the higher temperature deposition. Together, these results provide a fundamental understanding of the differences in the CO oxidation mechanism on Rh atoms and clusters.
Reduction of Dinitrobenzene Derivatives in Ethaline: Hydrogen‐Bonding Interactions through the Inversion of Potentials in a Deep Eutectic Solvent
Authors: Zhen Fangchen , Hapiot Philippe 
Published: July 2023

AbstractThe reduction of dinitro‐benzene derivatives have been examined in Ethaline containing a low amount of water (less than 0.2 %) chosen as a prototypical example of Type III‐DES. Analyses of the voltammograms reveal a situation of potential inversion (i. e. the second electron transfer is easier and occurs at a least negative potential) for the reductions of 1,2‐ and 1,4‐dinitrobenzene contrarily to the reduction of dinitrobenzene in a classical organic solvent. This is ascribed to H‐Bond interactions in Ethaline that are different for a delocalized radical anion and the dianion in a molecule bearing two conjugated redox groups. Indeed, the inversion of potential is not observed for the 1,3‐dinitrobenzene reduction. Reduction potentials in Ethaline are less negative than those in organic solvent (acetonitrile, DMF), that falls in line with the H‐bonding stabilization of the electrogenerated charged species in Ethaline. The potential inversion is not observed in ethylene glycol (with 0.2 mol L−1 Et4N+ Cl−) that is one of the components of Ethaline suggesting that choline chloride plays a major role in the H‐bonding/ion‐pairing stabilization. Interestingly and despite these stabilizations, the charge transfer kinetics remain comparable with those measured in common organic solvents (ks around 0.13 cm s−1).
Sugar‐Assisted Kinetic Resolutions in Metal/Chiral Amine Co‐Catalyzed α‐Allylations and [4+2] Cycloadditions: Highly Enantioselective Synthesis of Sugar and Chromane Derivatives
Authors: Zhang Kaiheng , Carmo Chrislaura , Deiana Luca , Grape Erik Svensson , Inge A. Ken , Córdova Armando 
Published: July 2023

AbstractFunctionalized triose‐, furanose and chromane‐derivatives were synthesized by the titled reactions. The sugar‐assisted kinetic resolution/C−C bond‐forming cascade processes generate a functionalized sugar derivative with a quaternary stereocenter in a highly enantioselective fashion (up to >99 % ee) by using a simple combination of metal and chiral amine co‐catalysts. Notably, the interplay between the chiral sugar substrate and the chiral amino acid derivative allowed for the construction of a functionalized sugar product with high enantioselectivity (up to 99 %) also when using a combination of racemic amine catalyst (0 % ee) and metal catalyst.
Longitudinal imaging in Kleefstra syndrome—Brief report and literature review
Authors: Castellucci Giovanni , Juhasz Csaba , Luat Aimee F. 
Published: July 2023

AbstractBackgroundKleefstra syndrome (KS) is a rare genetic condition affecting the euchromatic histone methyltransferase 1 (EHMT1) gene, typically presenting with developmental delay, generalized hypotonia, distinctive facial dysmorphisms, and neuropsychiatric anomalies.MethodsWe collected longitudinal magnetic resonance imaging (MRI) data of a child with KS and cerebrospinal fluid (CSF) dissection over 16 years and reviewed the literature focusing on articles reporting MRI findings in KS based on a PubMed search.ResultsAn 18‐year‐old female with KS presented with developmental delay at age 18 months and seizures at age 10 years. At age 23 months, MRI showed ventriculomegaly. Follow‐up MRI nine years later showed CSF dissection from the right lateral ventricle, which progressed similarly in the contralateral side 3 years later and stabilized over time. To date, only 20 articles report MRI findings from 49 patients with KS. The brain imaging findings range from normal (about 25%) to various abnormalities, including ventriculomegaly, white matter signal abnormalities, and dysmorphic corpus callosum and brainstem structures. CSF dissection was not found in any cases with white matter or other abnormalities.ConclusionsCSF dissection may be a rare neuroimaging finding of KS. Its etiology is unclear, but we speculate that epigenetic mutations could indirectly affect the development and integrity of ependymal cell lining along the ventricles. Alternatively, the long‐standing hydrocephalus may have caused the development of pseudodiverticula and subsequent CSF dissection.
Aging variations in Ishihara test plates
Authors: Plutino Alice , Armellin Luca , Mazzoni Andrea , Marcucci Roberta , Rizzi Alessandro 
Published: July 2023

AbstractThe Ishihara test plates are designed to offer a rapid and usable instrument to diagnose color deficiency. The original test, as well as other pseudo‐isochromatic plates (PIP), is composed of physical charts produced following proprietary and standard printing procedures. In this work, we aim to measure and assess the color shifts that the aging of the plates may introduce. This work aims to raise the scientific and medical community's awareness of the risks that may occur in using an aged or damaged test, which may still appear in good condition but has been subjected to deterioration over time.