bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instruments for the assessment of quality of life in children and adolescents with Down syndrome: A Scoping review
Authors: Rodríguez-Grande Eliana-Isabel , Díaz-Galvis Mayra-Liseth , Medina-Prieto Paula-Catalina , Vargas-Pinilla Olga-Cecilia , Torres-Narváez Martha-Rocío , Rodriguez-Malagón Nelcy 
Published: September 2023

Abstract

The construct of quality of life (QOL) includes aspects of health and well-being of people. Down syndrome (DS) or trisomy 21 is one of the most common congenital anomalies. DS is characterized by motor and cognitive alterations that affect health and QOL of both the child and caregiver.
In pediatrics, there are various instruments to assess Health-Related Quality of Life (HRQOL) and QOL. The advantage of these instruments is that they can be implemented in any type of disease and population in general. However, they may have certain disadvantages, such as the difficulty in evaluating specific aspects of each disease or condition related with Down syndrome. The aim of this study was to identify 1: instruments used to assess quality of life in children with Down syndrome. 2: psychometrics properties of instruments validated in children with Down syndrome to assess quality of life.
Methods: A Scoping review was conducted to identify instruments used in children and adolescents with Down syndrome and their psychometric properties. The electronic databases PubMed, Embase, Epistemonikos and other sources were explored with a search strategy that included keywords such as “Down syndrome,” “Quality of life” or “Life Quality,” “Health-Related Quality of Life” and psychometrics properties. The quality of the included studies was evaluated using the COSMIN (Consensus Based Standards for the Selection of Health Measurement Instruments) methodology.
Results: Thirteen studies were selected because they used some instrument to assess the quality of life in children or adolescents with Down syndrome. In these studies, eight instruments were used, of which only four have the report of some psychometric property in this population. Two of the eight evaluated quality of life and six health-related quality of life.
Conclusions: There is little information on the psychometric properties of instruments to assess quality of life and, above all, to assess health-related quality of life.It is necessary to create an instrument focused on children with DS to assess the health-related quality of life, which considers the particularities of their condition. Thus, it will be possible to determine how interventions from different areas can influence this functional condition
Does sulfate improve the Mn bioremediation efficiency of Polygonum lapathifolium Linn?
Authors: Long Xiaomei , Wang Yongsen , He Xiaoyan , Hong Yanyan , Guan Xiaojin , Yin Dengke , Liu Kehui 
Published: September 2023

Abstract
Polygonum lapathifolium Linn., as a hyperaccumulator, has a strong ability to bioaccumulate manganese (Mn). Sulfur (S) is an important micronutrient in plants and plays an important role in heavy metal detoxification and plant physiochemistry processes. In the present study, P. lapathifolium plants and two soils, one from a Mn mining area (Mn mine soil) and the other from a non-Mn mining area (farmland soil), were used to explore whether S has positive effects on plant growth and the efficiency of Mn bioremediation. The results showed that (1) although the biomass was similar between the two soils, the number of lateral branches in Mn mine soil was significantly greater than that in farmland soil, and S had a positive effect on root growth compared to a lack of S supplementation in each soil. (2) Sulfate promoted Mn uptake and transport from soil to plant in Mn mine soil but had no such effects in farmland soils. (3) Compared to those in farmland soil, the physiochemical parameters, including gas exchange characteristics, and chlorophyll pigments increased in Mn mine soil, and S promoted these effects. Although reactive oxygen species increased in Mn mine soil, the lower malondialdehyde content observed with S supplementation indicated its alleviatory role in the Mn-polluted environment. Antioxidant enzyme and nonantioxidant enzyme materials (total protein, total sugar and free proline) also showed the same positive effects. In conclusion, S improved the Mn enrichment efficiency of P. lapathifolium by promoting its root division in Mn mine soil, while the role of S in the physiochemical processes of P. lapathifolium was stronger in Mn mine soil than in farmland soil.
The Gut Bacterial Community of Wild and Captive Black Capuchin Monkeys (Sapajus Nigritus) in South Brazil Exhibit Environmental Influences
Authors: Grassotti Tiela Trapp , Lovison Otávio von Ameln , Kothee Caroline Isabel , Mann Michele Bertoni , Wagner Paulo Guilherme Carniel , Campos Aline Alves Scarpellini , Prichula Janira , Martins Andreza Francisco , Frazzon Jeverson , Frazzon Ana Paula Guedes 
Published: September 2023

Abstract
Black capuchin monkey (Sapajus nigritus), an endemic species of the Atlantic Forest in Brazil, faces challenges due to habitat loss and fragmentation. As a result, it is classified as near threatened. When the host is exposed to anthropogenic pressures, the gut microbial community can adapt to these stressful situations. This study aims to investigate the relationship between the habitat of black capuchin monkeys and their gut microbiome. Fecal samples were collected from the wild (n=27) and captive (n=7) monkeys, and their bacterial communities were analyzed using high-throughput sequencing of the 16S rRNA gene. The results revealed significant differences in the bacterial community structure between the two populations. Wild monkeys exhibited a higher abundance of Proteobacteria, Firmicutes, and Bacteroidota, while captive monkeys showed a higher abundance of Bacteroidota, Proteobacteria, and Firmicutes. Functional prediction analyses highlighted differences in pathways related to xenobiotic degradation between captive and wild groups. Wild monkeys in urban areas showed enrichment in dioxin biodegradation pathways, while those in farming environments exhibited pathways associated with toluene degradation. These findings underscore the gut microbiome's adaptability and unique functional capabilities under different environmental conditions. Furthermore, this study highlighted the gut microbiome and its response to ecological contexts, providing valuable insights into the understanding of black capuchin monkeys and supporting conservation efforts by establishing connections between the microbiota and primate habitat. Further research is required to explore the functional implications of these microbial differences and their potential effects on the health and well-being of black capuchin monkeys in diverse environments.
Exploring the Effect of Self-Efficacy on Spiritual Health among Middle-Aged and Older Adults with Chronic Diseases: An Empirical Study Based on Structural Equation Modeling
Authors: Chen Chiao-Shan , Sun Juo-Hsiang , Gan Wei-Xuan , Qiu Hsien-Hung , Yeh Wong Martin Thomas 
Published: September 2023

Abstract
Background:
By 2025, Taiwan is projected to enter a super-aging society. Although significant advancements in medical technology have been made, the challenges associated with chronic diseases persist, particularly the issue of "multiple comorbidities" that often accompanies aging. Maintaining good spiritual health is not only crucial for psychological well-being but also plays a significant role in disease recovery, fostering positive health behaviors, and improving overall well-being. This study therefore aimed to investigate the effect of self-efficacy on spiritual health and explore other influencing factors.
Methods:
Stratified sampling was employed to survey individuals aged 45 years or older, who had been diagnosed with chronic diseases for a duration exceeding 3 month. A total of 120 valid samples were obtained with an effective response rate of 93%. The research instruments used in this study consisted of a demographic information questionnaire, the Herth Hope Index, an Acceptance of Illness Scale, and a Spiritual Health Scale. The collected questionnaire data underwent analysis using a structural equation model.
Results:
Among middle-aged and older adults living with chronic diseases, hope in life was found to be positively associated with self-efficacy (β = 0.48, P < 0.000). Their acceptance of illness was also found to be positively correlated with self-efficacy (β = 0.20, P < 0.019). Furthermore, self-efficacy exerts a significant positive impact on various dimensions of spiritual health, encompassing religious sustenance (β = 0.23, P < 0.017), connection with oneself (β = 0.38, P < 0.000), the meaning of life (β = 0.56, P < 0.000), transcendence of adversity (β = 0.61, P < 0.000), and connection with nature (β = 0.43, P < 0.000).
Conclusions:
Self-efficacy has a positive impact on the spiritual health of older adults with chronic diseases. Higher levels of self-efficacy are associated with better spiritual health outcomes. Additionally, hope in life and acceptance of the disease influence self-efficacy, subsequently affecting spiritual health indirectly. Greater levels of hope in life and acceptance of the disease can lead to increased self-efficacy, which in turn contributes to improved spiritual health. In the future, enhancing spiritual health can be achieved by promoting factors that influence spiritual well-being. Individuals can make adjustments to their lifestyle and adopt healthy behaviors, thereby improving self-worth and fostering positive emotions that contribute to overall health improvement.
Group Health &amp; Wellness Coaching: Development and Validation of the Required Competencies
Authors: Wolever Ruth Q. , Cline Tim , Weiss Jocelyn M. , Carmack Suzie , Schultz Cindy , Arloski Michael , Lawson Karen 
Published: September 2023

Abstract
Background
As the popularity and demonstrated effectiveness of Health and Wellness Coaching (HWC) continue to grow to address chronic disease prevalence worldwide, delivery of this approach in a group format is gaining traction, particularly in healthcare. Nonetheless, very little empirical work exists on group coaching and no published competencies currently exist for Group Health and Wellness Coaching (GHWC).
Methods
We used a well-established two-phase (Development and Judgment) process to create and validate GHWC competencies with strong content validity.
Results
Seven highly qualified Subject Matter Experts systematically developed and proposed the GHWC competencies, which were then validated by 78 National Board Certified Health and Wellness Coaches (NBC-HWCs) currently practicing GHWC who rated the importance and use frequency of each one. The validation study led to 72 competencies which are organized into the structure and process of GHWC.
Conclusions
GHWC requires not only coaching skills, but significant group facilitation skills to guide the group process to best support members in maximizing health and well-being through self-directed behavioral change. As the presence of HWC continues to grow, it is imperative that GHWC skill standards be accepted and implemented for the safety of the public, the effectiveness of the intervention, and the value analysis of the field. Such standards will guide curriculum development, allow for a more robust research agenda, and give practical guidance for health and wellness coaches to responsibly run groups. High quality standards for GHWC are particularly needed in health care, where a Level III Current Procedural Terminology (CPT®) code for GHWC has been approved since 2019 and reimbursement of such has been proposed by the Centers for Medicare and Medicaid for 2024.
Prevalence and predisposing factors of covid-19 in Bwindi -Mgahinga mountain gorilla conservation area landscape, Uganda
Authors: Kungu Joseph M , Neumbe Joan , Kiganira Dan Brian , Tino Patience , Namayanja Josephine , Kassuja Ronald , Nankya Annet , Nizeyi John Bosco 
Published: September 2023

Abstract
Background: Mountain gorillas are endangered primate that share 99% of their DNA with humans. It is possible that the now mutated form of SARS-CoV2 in humans could spread to these endangered species. To estimate the potential risk of spread, a study to determine the prevalence of Covid19 in Bwindi Mgahinga Conservation Area landscape and its associated predisposing factors was done in communities of the three districts of Kanungu, Kisoro and Rubanda which host the Conservation Area. A cross sectional study was conducted on likely high-risk groups such as boda boda cyclists, tour guides, people in market places, community members and patients attending health care services.
Methods: Nasal pharyngeal swabs were obtained from 576 participants, 282 being female and 248 males. The samples were analyzed using conventional PCR test at Uganda Virus Research Institute (UVRI) and the prevalence of COVID19 determined. Demographic and other supporting data were collected using a structured questionnaire in kobo collect application in the field and was analyzed in Stata (version 14) using logistic regression to determine the risk factors associated with the prevalence of COVID19.
Results: The overall prevalence of COVID19 among people neighboring the conservation area was 8.0%, with Kanungu having the highest prevalence of 14.7% followed by Kisoro (11.0%) and Rubanda (6.2%). Wearing of a mask (p = 0.008, OR = 0.377), being in the age category of 20-39 years (p = 0.02, OR = 0.269) were protective factors, while hugging (p = 0.035, OR = 2.15) increased the risk of COVID-19 spread respectively.
Conclusion: It was evident in this study that COVID-19 occurred in communities around the Bwindi Mgahinga Conservation Area. Therefore, people working and visiting endangered mountain gorillas need to follow standard operating procedures particularly putting on masks to reduce the likelihood of transmitting Covid19 among humans as well as the gorillas
Fruit Intake and Respiratory Health: Results from Mendelian Randomization
Authors: Liao Wan-Zhe , Zhou Zhi-Yi , Chen Jun-Pan , Wen Ming-Hao , Yang Zhe-Han , Li Song-An , Guan Wei-Jie , Guo Xu-Guang 
Published: September 2023

Abstract
Background
Respiratory disease contributes to a substantial burden of disease and mortality. It continues to impact human health and the quality of life under the continuous advancements in prevention and treatment. As reported by previous research, dietary factors might be regarded as latent risk factors for lung disease, suggesting that a vegetarian diet can effectively reduce mortality.
Methods
In this study, genome-wide association studies (GWAS) were used to conduct Mendelian randomization (MR) analyses to explore the causal effect of fruit intake on respiratory disease burden including chronic obstructive pulmonary disease, bronchitis, emphysema, and asthma. MVMR was carried out to validate the results under the influence of the other kind of fruit intake.
Results
There was weak evidence for a possible causal relationship between fresh fruit intake and respiratory diseases, whereas a substantial and strong causality was found between dried fruit intake and the four outcomes (COPDIVW: OR (95% CI) = 0.32 (0.22, 0. 48), P value < 0.001; asthmaIVW: OR (95% CI) = 0.59 (0.44, 0.79), P value < 0.001; bronchitisIVW: OR (95% CI) = 0.50 (0.35, 0.73), P value < 0.001; emphysemaIVW: OR (95% CI) = 0.15 (0.05, 0.42), P value < 0.001), with stability confirmed by tests and MVMR.
Conclusions
Our study strengthens the evidence for a positive causal relationship between dried fruit intake and four common respiratory outcomes but fails to show an association between fresh fruit intake and the outcomes, and the reliability of the dietary intervention could be strengthened by further validation.
Rearing of black soldier fly larvae Hermetia illucens (L. 1758) based on substrates composed of water hyacinth leaves (Eichhornia crassipes)
Authors: VODOUNNOU Juste Vital , DOSSA Victor , DJISSOU Carmel , KPOGUE Diane , AGADJIHOUEDE Hyppolite , FIOGBE Emile Didier , Micha Jean-Claude 
Published: September 2023

Abstract

The aim of this sudy is to enhance Water Hyacinth (WH) leaves in the diet of Black Soldier Fly (BSF) larvae. Five different diets were formulated based on WH leaves and soy bran. The experimental device used is a complete random block consisting of 15 tanks (25 cm x 14 cm x 12 cm) arranged in triplicate and each containing 200 Hermetia illucens larvae. The experiment was done for 10 days. We notice significant differences between the different parameters. The Daily Weight Gain (DWG) varied from 2.54 ± 0.09 (R4) to 4.52 ± 0.02 (R0). Production varied from 50.87 ± 1.79 g/kg of substrate (R4) to 90.56 ± 0.54 g/kg of substrate (R0) and the Degradation Rate of substrates varied from 42.93 ± 1.79% (R4) to 65.00 ± 2.88% (R0). The survival rate varied from 91.33 ± 1.92% (R4) to 99.00 ± 0.28% (R0). Following the Z correlation test, a strong correlation (81.8%) is observed between the nitrogen in substrate and DWG of (BSF) larvae, as well as the degradation rate of the substrate (82.8%). This is also noticed with the organic matter content of the substrate which is strongly correlated with the DWG (97.6%) and the degradation rate of the substrate (91.6%). About nutritional quality of the larvae, a significant difference (p < 0.05) is observed between the different treatments. The protein varied from 31.47 ± 0.33% (R4) to 40.64 ± 032% (R0). The lipid varied from 15.36 ± 0.12% (R4) to 30.44 ± 0.18% (R0). It appears from this study that water hyacinth leaves mixed with SB can be valorized in the BSF larvae rearing
Naringenin induces different proliferative effects in estrogen receptor-alpha-66 negative breast cancer cells
Authors: Xu Zhixiang , Hu Siyuan , Luo Nao , Liu Jun , Ren Xiaomin , Pan Xuejun 
Published: September 2023

Abstract
Naringenin is a flavanone able to suppress the growth of various cancer cells including estrogen receptor-alpha-66 (ERα66)-positive breast cancer cells, but the anti-tumorigenic roles of naringenin in ERα66-negative breast cancer remain unclear. This study aims to determine the potential effects of naringenin on two ERα66-negative breast cancer cells (SKBR3 and MDA-MB-231) and to define their mechanisms of action. Herein, several cellular biological behaviors, including cell viability, migration, cycle, apoptosis, reactive oxygen species (ROS) generation, and oxidative stress (e.g., LDH, SOD and GSH), were evaluated in the present study. Then the gene expression levels involved in cell migration, cycle and apoptosis, as well as two membrane estrogen receptors (ERα36 and GPR30) were analyzed with real-time quantitative polymerase chain reaction (RT-qPCR) assay and western blotting. Results showed that naringenin exerted a concentration-dependent response on the growth of both ERα66-negative cell lines. The cell growth regulation was accompanied by modulation of cell migration, cycle and apoptosis, which were dependent on the ROS-regulated p53 signaling cascade. Importantly, ERα36 and GPR30 were involved in the (anti)-proliferative effects. These findings indicate naringenin possesses contrasting effects on ERα66-negative breast cancer cell growth depending on its dose
Cryo-EM analysis reveals human SID1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity
Authors: Shimizu Toshiyuki , Hirano Yoshinori , Ohto Umeharu , Sato Ryota , Miyake Kensuke 
Published: September 2023

Abstract
Two mammalian homologues of systemic RNA interference defective protein 1 (SID-1) (SIDT1/2) are suggested to function as double-stranded RNA (dsRNA) transporters for extracellular dsRNA uptake or for release of incorporated dsRNA from lysosome to cytoplasm. SIDT1/2 is also suggested to be involved in cholesterol transport and lipid metabolism. Here, we determine the cryo-electron microscopy structures of human SIDT1 homodimer in a side-by-side arrangement with two distinct conformations, the cholesterol-bound closed-form and the unbound open-form. Our structures revealed that the membrane spanning region of SIDT1 harbors conserved histidine and aspartate residues coordinating to putative zinc ion, in a structurally similar manner to alkaline ceramidases or adiponectin receptors that require zinc for ceramidase activity. We identified that SIDT1 has a ceramidase activity that is attenuated by cholesterol binding. Observations from two structures suggest that cholesterol molecules serve as allosteric regulator that binds the transmembrane region of SIDT1 and induces the conformation change and the reorientation of the catalytic residues.
Deep Learning Algorithms for Predicting Renal Replacement Therapy Initiation in CKD Patients: A Retrospective Cohort Study
Authors: Leung Ka-Chun , Ng Wincy Wing-Sze , Siu Yui-Pong , Hau Kai-Ching , Lee Hoi-Kan 
Published: September 2023

Abstract
Background: Chronic kidney disease (CKD) requires accurate prediction of renal replacement therapy (RRT) initiation risk. This study developed deep learning algorithms (DLAs) to predict RRT risk in CKD patients by incorporating medical history and prescriptions in addition to biochemical investigations.Methods: A multi-centre retrospective cohort study was conducted in three major hospitals in Hong Kong. CKD patients with an eGFR < 30ml/min/1.73m² were included. DLAs of various structures were created and trained using patient data. Using a test set, the DLAs' predictive performance was compared to Kidney Failure Risk Equation (KFRE).Results: DLAs outperformed KFRE in predicting RRT initiation risk (CNN + LSTM + ANN layers ROC-AUC = 0.90; CNN ROC-AUC = 0.91; 4-variable KFRE: ROC-AUC = 0.84; 8-variable KFRE: ROC-AUC = 0.84). DLAs accurately predicted uncoded renal transplants and patients requiring dialysis after 5 years, demonstrating their ability to capture non-linear relationships.Conclusions: DLAs provide accurate predictions of RRT risk in CKD patients, surpassing traditional methods like KFRE. Incorporating medical history and prescriptions improves prediction performance. Implementing DLAs can enhance patient care, reduce errors, and optimize resource allocation. Further research is needed to address DLA interpretability and expand the training dataset. This study emphasizes the potential of DLAs as valuable tools for predicting RRT risk and advancing CKD management.
Investigating the adsorption of humic acid from water using CTS/PAM and CTS/PAM/EDTA adsorbents
Authors: Alizadeh Mahdi , Abdi Sajjad , Abdoli Seyed Majid , Hazrati Hossein , Salami-Kalajahi Mehdi 
Published: September 2023

Abstract

In recent decades, reports from around the globe indicate an increase in natural organic substances in surface waters, which has a negative impact on drinking water purification and causes problems such as the taste and color of water, reducing the amount of dissolved oxygen in water, causing membrane fouling in the filtration process, and acting as a precursor for the formation of an antiseptic by-product. This work used the adsorption process to evaluate the elimination of natural organic compounds in aquatic environments. Ethylenediaminetetraacetic acid (EDTA) as a crosslinker for chitosan (CTS) and N, N-methylenebisacrylamide as a crosslinker for polyacrylamide (PAM) were used to prepare humic acid (HA) adsorbents utilizing a two-step procedure. The FTIR spectroscopy proved the EDTA cross-linking agent was effective with the semi-crosslinking CTS/PAM hydrogel. CTS/PAM/EDTA double network hydrogel exhibited a higher HA adsorption capacity (qe=107.7 mg/g) than CTS/PAM (qe=59.3 mg/g) at pH = 7 and an initial concentration of 60 mg. L− 1 during 60 min. Also, results demonstrate that CTS/PAM/EDTA double network hydrogels showed faster adsorption kinetics than CTS/PAM.