bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pendidikan Seksual Sejak Dini Bagi Orang Tua Siswa Terhadap Kemampuan Menjaga Diri Pada Anak Usia Dini
Authors: Yuni Husniati  , Dewa Gede Firstia Wirabrata  
Published: January 2025

Pendidikan seksual sering dianggap tabu untuk dibahas bersama anak. Orang tua dan siswa cenderung malu untuk membahas pendidikan seksual. Padahal pendidikan seksual sangat penting dibelajarkan sejak dini. Penelitian ini bertujuan untuk menganalisis hubungan antara pendidikan seksual sejak dini bagi orang tua siswa terhadap kemampuan menjaga diri pada anak usia dini. Jenis penelitian ini yakni penelitian ex post facto. Populasi pada penelitian ini adalah seluruh orang tua pada siswa-siswi di TK. Adapun jumlah populasi dalam penelitian ini yakni berjumlah 102. Sampel pada penelitian ini yakni orang tua siswa dari kelas kelompok B. dengan jumlah sampel 59. Metode dan instrument pengumpulan data yang dilakukan di penelitian ini adalah non tes yakni dengan kuesioner (angket). Metode analisis data yang digunakan dalam penelitian ini adalah metode analisis statistik deskriptif dan data analisis statistik inferensial. Hasil penelitian menunjukkan terdapat korelasi antara Pendidikan seksual sejak dini bagi orang tua siswa dengan kemampuan menjaga diri pada anak usia dini. Implikasi penelitian ini diharapkan mampu memotivasi orang tua terkait pentingnya pendidikan seksual bagi anak di taman kanak-kanak.
Pollution and its Impacts in Ennore Creek, Southeast Coast, India – A Review
Authors: Lakshmi V. V. , Ruby P. , Jayakumar N. 
Published: January 2025

The coastal ecosystem is essential to life on our planet as well as to the support of the livelihood of people living near and dependent on the coastal resources. The abundance of coastal resources of good quality is fundamental to all marine biological processes, for maintenance of biodiversity and ecosystems and for primary and secondary production functions that support human needs. Coastal ecosystems are ecologically important on the global scale and highly valuable for the services they supply. These include regulation services such as shoreline stabilization, nutrient regulation, carbon sequestration, and both detoxification of polluted waters and waste disposal; provisioning services such as supplying food, fuelwood, energy resources, and natural products; and amenity services such as coastal livelihoods, shipping, domestic tourism and recreation, and international tourism and recreation. In the seas, the marine life faces threats in many ways, such as overexploitation and harvesting, deposit of waste, contamination, exotic species, soil recovery, dredging and global climate change. One of the major kinds of human impact constitutes a major threat to marine life: the pollution by plastic debris. Most of the world’s important fisheries have now been damaged to varying extent; situations are even more critical in those fisheries that are already overexploited or otherwise vulnerable and, therefore, deserve immediate attention. Effective and sustainable management of coastal and marine environment should be initiated from local to international and global scale to ensure a sustained and best possible utilization of the resources for broader interest of mankind.
Effect of Bekang, Naturally Fermented Soyabean Food, as Alternative to Antibiotic Growth Promoter on Feed Efficiency, Blood Biochemical and Gut Health Parameters of Broiler Birds
Authors: Buragohain Rajat , Das Suraj 
Published: January 2025

The present study was conducted during the month of October-November, 2021 to assess effect of Bekang, naturally fermented soyabean food of Mizoram, on feed efficiency and gut health parameters of broilers as alternative to AGP. Total 240 day-old Vencobb-400 broiler chicks were assigned six dietary treatments dividing into six homogenous groups - standard rations (T1), standard rations with AGP (Bacitracin Methylene Disalicylate) @ 0.5 g kg-1 (T2), standard ration with fermented feed by Lactobacillus acidophilus (106–108 CFU g-1) @ 100 g kg-1 (T3), and standard rations with Bekang @ 50 g kg-1 (T4), 75 g kg-1 (T5) and 100 g kg-1 (T6), respectively. Findings revealed significant effect of Bekang on body weight gain at 42nd day of age, feed conversion ratio and economic return score of broilers. No significant effect was observed on blood biochemical parameters. Histomorphological studies revealed significantly (p<0.05) increased villi length, width, and decreased crypt depth in all prats of small intestine for Bekang supplementation. Caecal bacterial counts revealed increasing trend of lactic acid bacteria and decreased Salmonella and E. coli counts in T4, T5 and T6 compared to T1, T2 and T3. An increasing trend of antibody titre against NDV on 35th day of age indicated improvement of immune status in Bekang supplemented birds. From the findings, it was concluded that Bekang could be a potential alternative to AGP and could be recommended at a level of 50 g to 100 g kg-1 in rations of broiler birds.
Pengaruh Jenis Pupuk dan Tinggi Genangan terhadap Pertumbuhan dan Konsumsi Air Tanaman Padi (Oryza sativa L.) Varietas Padi M70D
Authors: Ridwan Ridwan , Amin Muhammad , Shelani Indah Sekar , Rosadi R.A Bustomi 
Published: January 2025

Food security improvement program is directed to be able to fulfil the food needs of people in the country from national food production. One of the national foodstuffs that is strived to be provided throughout the year is rice. The purpose of this study to obtain flooding height and type of fertilizer that can provide maximum M70D rice production and improve soil fertility. This study uses a completely randomized design (CRD) arranged in factorial 2x4 with three replications. The first factor is the application of water level consisting of 4 levels including (2 cm, 3 cm, 4 cm, and 5 cm). The second factor is the application of fertilizers consisting of ghally organic and Urea, TSP, and KCL fertilizers. The results showed that in general the treatment of 4cm flooding height and Urea, TSP, KCL fertilizer gave the best results on plant height, number of tillers, number of productive tillers, and number of rice grains. Meanwhile the treatment of ghally organic fertilizer can increase nutrients in the soil and rice plants. Ghally organic fertilizer has more role to improve soil structure and more efficient on water consumption of M70D rice plants. M70D rice plants cannot be applied by ghally organic fertilization using the spread method, because ghally organic fertilizers based on aerobic and anaerobic microba which can not work optimally in flooded conditions. Keyword: Fertilizer, Flooding Height, Nutrient, Paddy.
Assessment of transpulmonary thermodilution, ultrasound dilution, and esophageal Doppler against direct pulmonary artery flow for cardiac output monitoring in anesthetized cats
Authors: Liao Pen-Ting , Tillson Michael , Clark-Price Stuart , Kuo Kendon , Gerken Katherine , Claret Aina 
Published: January 2025

Abstract

OBJECTIVE
To assess the agreement of transpulmonary thermodilution (TPTD) and transpulmonary ultrasound dilution (TPUD) against direct measurement of main pulmonary artery flow with an ultrasound transit time flow probe (UTF) over a wide range of conditions in anesthetized cats. Additionally, the trending ability of TPTD, TPUD, and esophageal Doppler ultrasonography (EDU) was evaluated against UTF.

METHODS
12 purpose-bred cats were used. One cat was used for a pilot study. The cats were instrumented according to the manufacturer’s recommendation. Paired measurements were made over a wide range of cardiac output. Agreement was analyzed with Bland-Altman analysis with repeated measures, and trending ability was assessed by 4-quadrant plot and concordance rate. Interchangeable was defined as percentage error less than simplified total error. Acceptable trending was defined as concordance rate > 95%.

RESULTS
Bias and percentage error were −0.084 L·min−1 and 38.2% for TPTD and −0.041 L·min−1 and 52.9% for TPUD. The concordance rate was 100%, 95.5%, and 64% to 65% for TPTD, TPUD, and EDU, respectively.

CONCLUSIONS
Both TPTD and TPUD were not interchangeable to UTF. Both TPTD and TPUD provided acceptable trending ability but not EDU.

CLINICAL RELEVANCE
Transpulmonary thermodilution and TPUD allow detection of the direction of cardiac output changes in anesthetized cats but not EDU. Clinical and research use of these 3 devices warrants careful consideration of the limitations presented in this study.
DESAIN GRAFIS MEMPERKUAT DIGITAL MARKETING KEPADA WIRAUSAHA MUDA LDII KABUPATEN SUMENEP
Authors: Norsain Norsain , Pranata Mohammad Firlie , Dharmawan Johan 
Published: January 2025

Era digital menjadi tantangan dan peluang dalam berbisnis, tantangan dan peluang tersebut perlu dijawab dengan kemampuan yang diasah sesuai perkembangan. Para Pelaku bisnis online menjadi semakin diminati banyak kalangan, bahkan hampir semua masyarakat yang tidak memiliki toko secara umum juga melakukan penjualan online, Hal tersebut karena dianggap mudah dan praktis. Perkembangan tersebut juga harus diikuti para pemuda LDII di era digital.
Para Pemuda LDII merupakan pemuda yang aktif dalam melakukan binsis dan usaha bertujuan untuk mensejahterakan para anggota khususnya dan masyarakat sumenep pada umumnya yang menikmati fasilitas tersebut.
Diusianya yang masih dini tersebut masih belum memanfaatkan penjualan di dunia online karena keterbatasan sumber daya manusia, hal tersebut telah diupayakan mendapatkan solusi dengan adanya pelatihan dan pengabdian dari Universitas Wiraraja dan mahasiswa bisnis digital. Para pemuda LDII yang minim pengetahuan dan masih belum memiliki pengalaman penjualan online. Untuk mengatasi hal tersebut maka diperlukan adanya pelatihan dan pendampingan terkait tentang menjadi seorang digital marketer.
Program pengabdian ini diharapkan dapat menjadi langkah awal memulai usaha online dengan mereka dituntut memiliki mental yang kreatif dan inovatif.
FORMULATION DEVELOPMENT, OPTIMIZATION AND EVALUATION OF FAMOTIDINE FLOATING MATRIX TABLETS
Authors: Patel Manish P. , Patel Madhabhai M. , Patel Dipti H. , Patel Krishnakumar N. 
Published: January 2025

The purpose of this research work was to prepare a gastroretentive drug delivery system of Famotidine. This study investigated utility of a 3-factor, 3-level Box-Behnken design and optimization process for floating tablet of famotidine with 5 replicates of center points. Amount of HPMC K4 (Hydroxy Propyl Methyl cellulose), amount of NaHCO3 and amount of citric acid were selected as the independent variables whereas total floating time (TFT), half life, % cumulative drug release at 10 hrs, and diffusion coefficients (n) were selected as dependent variables. The prepared tablets of famotidine were evaluated for dissolution study and found to follow zero order release kinetic. The responses were analyzed using ANOVA and the individual response parameters were evaluated using F test and polynomial equation was generated for each response using MLRA. The amount of HPMC K4 and amount of citric acid were found to significantly influence all response parameters selected whereas the amount of NaHCO3 has significant effect on TFT. Optimum amount of HPMC K4, NaHCO3, and citric acid is important in achieving good floating time and minimum floating lag time. It was clear from dissolution profiles that the tablets of batch F3, F7, and F12 exhibits initial burst phase during the first hour of dissolution. The burst phase was followed by a limited drug release for the rest of the period. The produced tablets exhibited good floating time and controlled drug release over a period of 12 h. The resultant data were critically analyzed to locate the composition of optimum formulations. All predicted values of response variables of optimized formulation demonstrated close agreement with the experimental data during optimization procedure.
A COMPREHENSIVE REVIEW OF DIFFERENT LIVER TOXICANTS USED IN EXPERIMENTAL PHARMACOLOGY
Authors: Bigoniya P. , Singh C. S. , Shukla A. 
Published: January 2025

Liver is a primary organ involved in metabolism of food and drugs. Liver disorders are mainly caused by toxic chemicals, such as antibiotics, chemotherapeutic agents, peroxidised oil, aflatoxin, carbon tetrachloride, chlorinated hydrocarbons etc. Toxic liver injury produced by drugs and chemicals may virtually mimic any form of naturally occurring liver disease. In view of multiplicity and complexity of the liver functions, it is obvious that no single test can establish the disturbances in liver function. Thus, a battery of liver function tests is employed for accurate diagnosis, to assess the severity of damage, to judge prognosis and to evaluate therapy. To study hepatoprotective potential of any herbal product, isolated phytochemical or synthetically developed moiety induction of experimental liver damage is prerequisite. The selection of toxicant depends on type and nature of liver damage required as every toxicant has its unique mode of action producing specific type of destruction. The hepatoprotective mechanism of any drug under study can be explained based on its protective behavioragainst different toxicants. This review is precise compilation of experimental liver pharmacology taking concern dose, route, and schedule of different liver toxicants along with evaluation biochemical, histological and functional ability parameters. The literature compilation will definitely help researcher in design and assessment of studies involving liver function.
OPTIMIZATION AND VALIDATION OF MODULATED RELEASE FORMULATION OF RANITIDINE HCL BY RESPONSE SURFACE METHODOLOGY
Authors: Sahoo Bijay Kumar , Mishra Amiya Kumar , Pal Tapan Kumar 
Published: January 2025

The objective of the present study was, 1) to systematically device a model of factors that would yield an optimized sustained release dosage form of model drug (Ranitidine HCl), 2) to validate the models using R2 values, 3) to optimize the formulation by response surface methodology (RSM). A three - factor, three - level Box-Behnken design was used for the optimization procedure, with the amounts of HPMC K100M (X1), MCC (X2) and Compression Force (X3) as independent variables. Three dependent variables were considered: percentage of drug release at 1 h, 12 h and T50%. The regression equation obtained from experiment i. e Y2 = 92.41 + 3.18X1+ 2.05 X2 + 2.14X3 + 2.41X1X2 + 0.24 X1X3 + 0.11 X2X3 -3.82X12- 2.59X22 -0.46X32 , explained the main and interaction effects of factors that influenced the drug release. Optimization was performed by maximizing the drug release in 12 hrs and placing constraints on Y1, Y2 and Y3. Validation of optimization by carrying out by performing 8 experimental runs showed high degree of prognostic ability of response surface methodology. The results showed that the optimized formulation provided a dissolution pattern similar to the predicted curve, which indicated that the optimal formulation could be obtained using RSM. A simple high performance liquid chromatography method was developed and the dissolution samples were analysed by this procedure.
THE THE INFLUENCE OFTRANSFORMATIONAL LEADERSHIP STYLE,WORK MOTIVATION, EMPLOYEE PERFORMANCE ANDPERCEIVED OF THE MEANINGFULNESS OF WORK
Authors: Br Ginting Ginka Febriyanti , Purwandari Dian Alfia , Anindita Rina 
Published: January 2025

Penelitian ini bertujuan mengeskplorasi pengaruh gaya kepemimpinan transformasional terhadap kinerja karyawan, gaya kepemimpinan transformasional terhadap motivasi kerja, motivasi kerja terhadap kinerja karyawan, gaya kepemimpinan transformasional terhadap kinerja karyawan dengan motivasi sebagai mediasi,gaya kepemimpinan transformasional terhadap persepsi kebermaknaan kerja, dan persepsi kebermaknaan kerja terhadap motivasi kerja. Studi ini menggunakan pendekatan kuantitatif dengan metode survey yang menyebarkan kuesioner secara online kepada 325 orang karyawan yang bekerja pada bagian staf administrasi di kantor pusat industri manufaktur di wilayah DKI Jakarta. Responden penelitian ini dipilih dengan metode purposive sampling. Penelitian dilakukan dengan metode Structural Equation Model (SEM). Dari hasil penelitian ini ditemukan bahwa gaya kepemimpinan transformasional tidak berpengaruh terhadap kinerja karyawan, gaya kepemimpinan transformasional berpengaruh terhadap motivasi kerja, motivasi kerja berpengaruh terhadap terhadap kinerja karyawan, gaya kepemimpinan transformasional memiliki pengaruh terhadap kinerja karyawan dengan motivasi sebagai mediasi, gaya kepemimpinan transformasional berpengaruh terhadap persepsi kebermaknaan kerja, persepsi kebermaknaan kerja berpengaruh terhadap motivasi kerja. Disarankan pada penelitian berikutnya dapat dilakukan analisis mengenai gaya kepemimpinan transformasional pada bidang atau sektor industri lain yang cakupan wilayahnya lebih luas. Kedua, dapat dilakukan penelitian lebih lanjut dengan melibatkan pekerja yang tidak hanya bekerja di kantor pusat sebagai pegawai administrasi tetapi juga melibatkan pekerja di bidang lain, seperti pegawai operasional lapangan di pabrik.
COURSE OF CHRONIC HEPATITIS D IN THE INDIGENOUS POPULATION OF THE SAKHA REPUBLIC (YAKUTIA)
Authors: Zamorshchikova O. M. , Sleptsova S. S. , Sleptsov S. S. 
Published: January 2025

The relevance of studying viral hepatitis D is associated with the increasing prevalence of the disease worldwide and an aggressive clinical course compared to other parenteral hepatitis. The Sakha Republic (Yakutia) is a territory of the Russian Federation with a high level of prevalence of hepatitis D virus among the indigenous population. While effective antiviral therapy does not cover all patients in need, chronic HDV-infection leads to the rapid formation of disabling forms of liver disease. The aim of the work was to study the clinical and laboratory features of the course of HDV-infection among the indigenous population of the Sakha Republic (Yakutia) for further use of data in the development of a prognostic model to identify the risk of severe course such as HD-cirrhosis of the liver. We examined 157 patients at different stages of the disease: 71 men and 86 women, aged between 22 and 77 years, with the average age at 48 ± 10.5 years. It was found that 30.6 % of chronic hepatitis proceeds without severe liver ﬁbrosis; 56.1 % of patients have cirrhosis; and 13.3 % have hepatocarcinoma. Liver cirrhosis develops on average 6.8 years after detection of anti-HDV. Epidemiologically signiﬁcant risk factors for severe course are a history of acute hepatitis B (p=0.038) and intrafamilial contact (p=0.02). The study of the clinical and laboratory picture showed an increase in the severity of the patients’ condition with the formation of cirrhosis and liver cancer. Mixed replication of HBV/HDV was signiﬁcantly more often (p<0.001) observed in patients with cirrhosis and HCC. The overall mortality rate among patients was 17.8 % and the main cause of death was progressive liver failure.Conclusion: The territory of the Sakha Republic (Yakutia) is unfavorable in terms of the prevalence of chronic forms of HDV infection. The analysis conﬁrmed a high risk of developing severe ﬁbrosis among the indigenous population in 69 %, which requires strengthening measures for the early diagnosis of complications, as well as increasing the coverage of antiviral treatment for patients in the region.
H49R MUTATION OF THE SOD1 GENE AS A CAUSE OF PROGRESSIVE MUSCULAR ATROPHY: A CLINICAL CASE
Authors: Syromiatnikov N. N. , Tappakhov A. A. , Davydova T. K. , Konnikova E. E. , Khabarova Y. I. 
Published: January 2025

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease within the spectrum of motor neuron disorders, selectively targeting central and peripheral motor neurons in the brain and spinal cord, with highly variable clinical manifestations. One rare form of ALS is progressive muscular atrophy (PMA), primarily characterized by the selective involvement of peripheral motor neurons and a slower, less aggressive progression compared to classical ALS. Currently, the scientiﬁc community lacks consensus on whether PMA should be classiﬁed as a distinct nosological entity or as a subtype of ALS.Recent advancements in genetic research have identiﬁed that familial and hereditary forms of ALS are most frequently linked to mutations in the SOD1, TARDBP, C9orf72, and FUS genes, among others. Moreover, increasing progress in genetic testing now enables the identiﬁcation of mutant genes responsible for various phenotypes. Understanding the genetic underpinnings of motor neuron diseases is crucial for elucidating their pathogenesis, which may pave the way for the development of novel diagnostic and therapeutic strategies.This article presents a clinical case involving a patient with a PMA phenotype associated with the H49R mutation in the SOD1 gene. A comprehensive account of the patient’s anamnesis, clinical presentation, molecular-genetic ﬁndings, as well as results from instrumental investigations, including electromyography and magnetic resonance imaging, is provided. The article discusses the potential nosological autonomy of PMA and its association with the H49R mutation, referencing current data from both Russian and international studies. Additionally, the article highlights the challenges of differential diagnosis, particularly in distinguishing PMA from other neurodegenerative diseases with similar clinical proﬁles.This case contributes to the expanding knowledge of the heterogeneity of motor neuron diseases and underscores the importance of molecular-genetic testing in predicting disease prognosis and guiding patient management.
ОПРЕДЕЛЕНИЕ ПЕРВОНАЧАЛЬНЫХ НАПРЯЖЕНИЙ МАССИВА ГОРНЫХ ПОРОД В УСЛОВИЯХ КЫЗЫЛ-ТАШТЫГСКОГО МЕСТОРОЖДЕНИЯ
Authors: Сентябов С.В. , Ушаков Е.М. 
Published: January 2025

Оценку напряженного состояния конструктивных элементов камерных систем разработки с обрушением крепких руд необходимо производить при решении геомеханических задач на основе выявленного несоответствия параметров прочностных свойств скальных горных пород, определенных по существующим методикам, их значениям в натурных условиях. Разница между полученными значениями данных параметров может достигать 1,8 раза. В процессе исследований определены параметры природного напряженно-деформированного состояния (НДС) массива горных пород на основе проведенных натурных исследований в условиях интенсивной разработки Кызыл-Таштыгского месторождения подземным способом. Исследования направлены на снижение и прогнозирование риска геодинамических явлений при ведении горных работ. Данная задача неосуществима без ведения мониторинга напряженного состояния месторождения, информационного обеспечения недропользователей при геологическом изучении и разработке месторождения полезного ископаемого. Исследования проведены с помощью общепринятых методов и аппаратуры, согласно требованиям инструктивных документов. Таким образом, расчетный геомеханический прогноз и определение первоначального напряженного состояния на рудниках остаются до настоящего времени весьма актуальными.
An assessment of the stress state of structural elements of chamber mining systems with the collapse of hard ores is to be made when solving geomechanical problems based on the identified discrepancy between the parameters of the strength properties of rocks, determined by existing methods, and their values in natural conditions. The difference between the obtained values of these parameters can reach 1,8 times. In the process of research, the parameters of the natural stress-strain state (SSS) of the rock mass were determined based on field studies carried out under the conditions of intensive underground development of the Kyzyl-Tashtyg deposit. Research is aimed at reducing and predicting the risk of geodynamic phenomena during mining operations. This task is not feasible without monitoring the stressed state of the deposit and providing information to subsoil users during the geological study and development of a mineral deposit. The studies were carried out using generally accepted methods and equipment, in accordance with the requirements of the instructional documents. Thus, the calculated geomechanical forecast and determination of the initial stress state in mines remain very relevant to this day.