bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic kidney disease intervention in primary health care: integrative review
Authors: Forin Paes Andyara Thalissa , Barbieri Ana Rita , Insabralde de Queiroz Cardoso Andréia , Ferreira Júnior Marcos Antônio 
Published: January 2023

To analyze the knowledge and safety of primary health care professionals in the management of chronic kidney disease in its early stages. Integrative literature review carried out in four steps. The search took place in the following databases: MEDLINE via PubMed, Web of Science, Scopus and BVS. The descriptors used were “Primary Health Care” AND “Kidney Diseases” AND “Health Knowledge, Attitudes, Practice” and the quality of the analysis was checked by means of the Hierarchy of Evidence for Intervention Studies”. Fifteen articles were found, with a predominance of qualitative and descriptive method; the results showed insufficient knowledge of health professionals and interest in the best approach in the initial stage of the disease. Thus, it is inferred that the knowledge and security of primary health care professionals depend on individual factors and institutional initiative for the adoption of clinical guidelines and training. Therefore, prepared professionals and organized care, using protocols, would bring benefits both to patients as to the evolution and outcome of the disease and savings to health services.
Giant Aneurysm of Left Main Coronary Artery in a Patient With Prior Operation for 4-Valve Endocarditis
Authors: Abudayyeh Islam , Tankazyan Hambik , Heimes Jessica , Rabkin David G. , Razzouk Anees J. 
Published: January 2023

Abstract
Left main coronary artery aneurysm is an unusual complication of infective endocarditis. Although this type of aneurysm is often asymptomatic, rupture and thrombus formation that result in myocardial infarction are known complications; therefore, prompt recognition and surgical intervention are warranted. This report describes a patient who presented with a giant left main coronary artery aneurysm 3.5 years after being treated for 4-valve endocarditis. The management and technical aspects of this challenging case are discussed here.
PENGUKURAN KUALITAS LAYANAN BERDASARKAN DIMENSI SERVICE QUALITY (SERVQUAL) DENGAN METODE ZONE OF TOLERANCE (ZOT) DAN KANO PADA PET WORLD
Authors: Rahmawati Dewi , Aulawi Hilmi , Kurniawati Rina 
Published: January 2023

Pet World merupakan salah satu jasa pelayanan kebutuhan hewan peliharaan yang berada di Kabupaten Garut, namun pemenuhan tingkat kepuasan pelanggan belum dapat dilakukan secara optimal. Tujuan dari penelitian ini adalah untuk mengetahui tingkat layanan berdasarkan pada dimensi kualitas yang diberikan terhadap kepuasan pelanggan serta menghasilkan usulan perbaikan untuk meningkatkan kualitas layanan pada Pet World. Penelitian ini menggunakan pendekatan Mix Method dimana data kualitatif dilakukan untuk menguji validitas dan reliabilitas. Sedangkan data kuantitatif digunakan untuk pengolahan metode Servqual untuk mengukur kepuasan pelanggan, metode ZOT untuk mengukur apakah pelayanan masih dalam batas toleransi, dan metode kano untuk mengukur prioritas.Hasil penelitian menunjukan bahwa atribut layanan yang tidak memuaskan atau atribut yang memiliki gap score negatif yaitu dua atribut pada dimensi tangibles dalam segi kenyamanan dan keamanan, satu atribut pada dimensi reliability pada segi ketepatan dalam produk serta satu atribut pada dimensi responsivenes pada segi akses informasi. Selain itu, metode Servqual, ZOT, dan Kano relevan dengan penelitian yang dilakukan karena pada metode ini mengukur kualitas layanan berdasarkan pada dimensi kualitasnya serta berorientasi pada kepuasan pelanggan. Abstract[Measurement of Service Quality Based on Service Quality (Servqual) Dimensions With Zone of Tolerance (ZOT) and Kano on Pet World] Pet World is one of the services for pet needs in Garut Regency, but the fulfillment of the customer satisfaction level has not been optimal. The purpose of this study was to know the level of service based on the dimensions of quality provided to customer satisfaction and to produce suggestions for improvements to improve service quality at Pet World. This study used a Mix Method approach. The Qualitative data was used to test the validity and reliability. The quantitative data was used for processing the Servqual method to measure customer satisfaction, the ZOT method to measure whether the service is still within tolerance limits, and the Kano method to measure priority. The results showed unsatisfactory service attributes or attributes with a negative gap score were two attributes on the tangibles dimension in terms of comfort and security, one on the reliability dimension in terms of product accuracy, and one on the responsiveness dimension in terms of access to information. In addition, the Servqual, ZOT, and Kano methods are relevant to the research conducted because this method measures service quality based on its dimensions and does orient to customer satisfaction.Keywords: Kano; Mix Method; service quality; zone of tolerance
The Democratic Challenge of Central Bank Credit Policies
Authors: Monnet Eric 
Published: January 2023

Abstract
This article provides a framework for understanding the economic role of central banks and their democratic legitimacy. I argue that thinking about the democratic challenges of central banking requires considering central banks’ insurance role and how their actions are part of credit policy. The contract between the central bank and the sovereign is incomplete because it cannot integrate all unforeseen contingencies, distributive consequences and interactions with other policies. This opens the door to viewing the legitimacy of central bank decisions through a process of deliberation, coordination and reflexivity, rather than only a delegation of power. I discuss a proposal for a European Credit Council, which would be a deliberative body aimed at strengthening Parliamentary power on monetary and credit policies, the democratic legitimacy of central bank policy in the Euro Area as well as its coordination with other European policies. More coordination, Parliamentary power and deliberation are consistent with central bank independence and aim to delimit more precisely the action of central banks within the macroeconomic and credit policies of the State.
The Changing Determinants of Juvenile Crime
Authors: Belley Philippe , Castex Gonzalo , Dechter Evgenia 
Published: January 2023

Abstract
Following decades of increasing crime rates in the U.S., crime participation declined substantially throughout the 1990s, and have remained low in the 2000s. Using the 1979 and 1997 waves of the National Longitudinal Survey of Youth, we identify the determinants of criminal involvement and antisocial behavior. In the 1980s compared to the 2000s, youth from disadvantaged family backgrounds, those with lower skills, and those in urban areas were more disproportionately represented in crime participation. Our results suggest that most of the decline in crime is related to changes in the socio-economic environment and public policy shifts.
ISO 15189 is a sufficient instrument to guarantee high-quality manufacture of laboratory developed tests for in-house-use conform requirements of the European In-Vitro-Diagnostics Regulation
Authors: Vanstapel Florent J.L.A. , Orth Matthias , Streichert Thomas , Capoluongo Ettore D. , Oosterhuis Wytze P. , Çubukçu Hikmet Can , Bernabeu-Andreu Francisco A. , Thelen Marc , Jacobs Leo H.J. , Linko Solveig , Bhattoa Harjit Pal , Bossuyt Patrick M.M. , Meško Brguljan Pika , Boursier Guilaine , Cobbaert Christa M. , Neumaier Michael 
Published: January 2023

Abstract
The EU In-Vitro Diagnostic Device Regulation (IVDR) aims for transparent risk-and purpose-based validation of diagnostic devices, traceability of results to uniquely identified devices, and post-market surveillance. The IVDR regulates design, manufacture and putting into use of devices, but not medical services using these devices. In the absence of suitable commercial devices, the laboratory can resort to laboratory-developed tests (LDT) for in-house use. Documentary obligations (IVDR Art 5.5), the performance and safety specifications of ANNEX I, and development and manufacture under an ISO 15189-equivalent quality system apply. LDTs serve specific clinical needs, often for low volume niche applications, or correspond to the translational phase of new tests and treatments, often extremely relevant for patient care. As some commercial tests may disappear with the IVDR roll-out, many will require urgent LDT replacement. The workload will also depend on which modifications to commercial tests turns them into an LDT, and on how national legislators and competent authorities (CA) will handle new competences and responsibilities. We discuss appropriate interpretation of ISO 15189 to cover IVDR requirements. Selected cases illustrate LDT implementation covering medical needs with commensurate management of risk emanating from intended use and/or design of devices. Unintended collateral damage of the IVDR comprises loss of non-profitable niche applications, increases of costs and wasted resources, and migration of innovative research to more cost-efficient environments. Taking into account local specifics, the legislative framework should reduce the burden on and associated opportunity costs for the health care system, by making diligent use of existing frameworks.
CuO–Cu/water hybrid nonofluid potentials in impingement jet
Authors: Abdulwahid Ammar F. , Kareem Zaid S. , Balla Hyder H. , Hashim Noora A. , Abbud Luay H. 
Published: January 2023

Abstract
The present study considered an impingement jet using hybrid nanofluid CuO–Cu/water. A single rounded nozzle was used to impinge a turbulent coolant (water) on the hot circular plate at Reynold’s number range of (5,000–15,000). CuO–Cu nanoparticles were physically synthesized at 50 nm size and dispersed by one-step preparation method. The experimentations were conducted with nanoparticle concentrations range of (0.2–1%) by volume. The results showed that the presence of hybrid nanoparticles exhibits a significant improvement in the overall thermal performance of the working fluid. Where the gained heat interpreted by the Nusselt number was found to be 2.8% (in comparing with deionized water) at ϕ = 1% and Re = 15,000, while the minimum gain in the heat was found to be 0.93% at ϕ = 0.2% and Re = 5,000. Furthermore, it was noted that the excessive increase in CuO–Cu nanoparticle concentration causes more pumping power consumption. Moreover, the CuO–Cu nanoparticles residual layer was found to be formed at a high CuO–Cu concentration, which acts as an insulation layer that hinders the heat exchange. It was also found that the threshold of nozzle-to-plate spacing is H = 4, before which, the heat gain is positive, and negative plummet after.
Detection of different chemical moieties in aqueous media by luminescent Europium as sensor
Authors: Bashir Komal , Jamil Faisal , Iqbal Muhammad Adnan , Nazir Sadia , Shoukat Umar Sohail , Bashir Anam , Nasrullah Kainat , Rehman Ateeq-Ur 
Published: January 2023

Abstract
Detection of different chemical moieties especially trace metals is important for humans as well as water safety. In this review, different detectors synthesized by the combination of different ligands with luminescent europium complexes were discussed for the separation of metals and chemical moieties in aqueous media. These detectors displayed high sensitivity and selectivity. The limit-of-detection values were very low indicating that these detectors are best suitable for the sensing of chemical moieties and trace metals. These detectors’ luminescent changes could be noticed with the naked eye.
Adolescent Parvalbumin Expression in the Left Orbitofrontal Cortex Shapes Sociability in Female Mice
Authors: Jeon Yi-Seon , Jeong Daun , Kweon Hanseul , Kim Jae-Hyun , Kim Choong Yeon , Oh Youngbin , Lee Young-Ho , Kim Chan Hyuk , Kim Sang-Gyu , Jeong Jae-Woong , Kim Eunjoon , Lee Seung-Hee 
Published: January 2023

The adolescent social experience is essential for the maturation of the prefrontal cortex in mammalian species. However, it still needs to be determined which cortical circuits mature with such experience and how it shapes adult social behaviors in a sex-specific manner. Here, we examined social-approaching behaviors in male and female mice after postweaning social isolation (PWSI), which deprives social experience during adolescence. We found that the PWSI, particularly isolation during late adolescence, caused an abnormal increase in social approaches (hypersociability) only in female mice. We further found that the PWSI female mice showed reduced parvalbumin (PV) expression in the left orbitofrontal cortex (OFCL). When we measured neural activity in the female OFCL, a substantial number of neurons showed higher activity when mice sniffed other mice (social sniffing) than when they sniffed an object (object sniffing). Interestingly, the PWSI significantly reduced both the number of activated neurons and the activity level during social sniffing in female mice. Similarly, the CRISPR/Cas9-mediated knockdown of PV in the OFCLduring late adolescence enhanced sociability and reduced the social sniffing-induced activity in adult female mice via decreased excitability of PV+neurons and reduced synaptic inhibition in the OFCL. Moreover, optogenetic activation of excitatory neurons or optogenetic inhibition of PV+neurons in the OFCLenhanced sociability in female mice. Our data demonstrate that the adolescent social experience is critical for the maturation of PV+inhibitory circuits in the OFCL; this maturation shapes female social behavior via enhancing social representation in the OFCL.SIGNIFICANCE STATEMENTAdolescent social isolation often changes adult social behaviors in mammals. Yet, we do not fully understand the sex-specific effects of social isolation and the brain areas and circuits that mediate such changes. Here, we found that adolescent social isolation causes three abnormal phenotypes in female but not male mice: hypersociability, decreased PV+neurons in the left orbitofrontal cortex (OFCL), and decreased socially evoked activity in the OFCL. Moreover, parvalbumin (PV) deletion in the OFCLin vivocaused the same phenotypes in female mice by increasing excitation compared with inhibition within the OFCL. Our data suggest that adolescent social experience is required for PV maturation in the OFCL, which is critical for evoking OFCLactivity that shapes social behaviors in female mice.
Postsynaptic NMDA Receptor Expression Is Required for Visual Corticocollicular Projection Refinement in the Mouse Superior Colliculus
Authors: Johnson Kristy O. , Harel Leeor , Triplett Jason W. 
Published: January 2023

Efficient sensory processing of spatial information is facilitated through the organization of neuronal connections into topographic maps of space. In integrative sensory centers, converging topographic maps must be aligned to merge spatially congruent information. The superior colliculus (SC) receives topographically ordered visual inputs from retinal ganglion cells (RGCs) in the eye and layer 5 neurons in the primary visual cortex (L5-V1). Previous studies suggest that RGCs instruct the alignment of later-arriving L5-V1 inputs in an activity-dependent manner. However, the molecular mechanisms underlying this remain unclear. Here, we explored the role of NMDA receptors in visual map alignment in the SC using a conditional genetic knockout approach. We leveraged a novel knock-in mouse line that expresses tamoxifen-inducible Cre recombinase under the control of theTal1gene (Tal1CreERT2), which we show allows for specific recombination in the superficial layers of the SC. We usedTal1CreERT2mice of either sex to conditionally delete the obligate GluN1 subunit of the NMDA receptor (SC-cKO) during the period of visual map alignment. We observed a significant disruption of L5-V1 axon terminal organization in the SC of SC-cKO mice. Importantly, retinocollicular topography was unaffected in this context, suggesting that alignment is also disrupted. Time-course experiments suggest that NMDA receptors may play a critical role in the refinement of L5-V1 inputs in the SC. Together, these data implicate NMDA receptors as critical mediators of activity-dependent visual map alignment in the SC.SIGNIFICANCE STATEMENTAlignment of topographic inputs is critical for integration of spatially congruent sensory information; however, little is known about the mechanisms underlying this complex process. Here, we took a conditional genetic approach to explore the role of NMDA receptors in the alignment of retinal and cortical visual inputs in the superior colliculus. We characterize a novel mouse line providing spatial and temporal control of recombination in the superior colliculus and reveal a critical role for NMDA expression in visual map alignment. These data support a role for neuronal activity in visual map alignment and provide mechanistic insight into this complex developmental process.
Outcome of COVID-19 infections in patients with adrenal insufficiency and excess
Authors: Nowotny Hanna F , Bryce Jillian , Ali Salma R , Giordano Roberta , Baronio Federico , Chifu Irina , Tschaidse Lea , Cools Martine , van den Akker Erica LT , Falhammar Henrik , Appelman-Dijkstra Natasha M , Persani Luca , Beccuti Guglielmo , Ross Ian L , Grozinsky-Glasberg Simona , Pereira Alberto M , Husebye Eystein S , Hahner Stefanie , Faisal Ahmed S , Reisch Nicole 
Published: January 2023

Background
Information on clinical outcomes of coronavirus disease 19 (COVID-19) infection in patients with adrenal disorders is scarce.

Methods
A collaboration between the European Society of Endocrinology (ESE) Rare Disease Committee and European Reference Network on Rare Endocrine Conditions via the European Registries for Rare Endocrine Conditions allowed the collection of data on 64 cases (57 adrenal insufficiency (AI), 7 Cushing’s syndrome) that had been reported by 12 centres in 8 European countries between January 2020 and December 2021.

Results
Of all 64 patients, 23 were males and 41 females (13 of those children) with a median age of 37 and 51 years. In 45/57 (95%) AI cases, COVID-19 infection was confirmed by testing. Primary insufficiency was present in 45/57 patients; 19 were affected by Addison’s disease, 19 by congenital adrenal hyperplasia and 7 by primary AI (PAI) due to other causes. The most relevant comorbidities were hypertension (12%), obesity (n = 14%) and diabetes mellitus (9%). An increase by a median of 2.0 (IQR 1.4) times the daily replacement dose was reported in 42 (74%) patients. Two patients were administered i.m. injection of 100 mg hydrocortisone, and 11/64 were admitted to the hospital. Two patients had to be transferred to the intensive care unit, one with a fatal outcome. Four patients reported persistent SARS-CoV-2 infection, all others complete remission.

Conclusion
This European multicentre questionnaire is the first to collect data on the outcome of COVID-19 infection in patients with adrenal gland disorders. It suggests good clinical outcomes in case of duly dose adjustments and emphasizes the importance of patient education on sick day rules.
SNAP Participation and Emergency Department Use
Authors: Sonik Rajan Anthony , Coleman-Jensen Alisha , Creedon Timothy B. , Yang Xinyu 
Published: January 2023

OBJECTIVES
To examine whether Supplemental Nutrition Assistance Program (SNAP) participation is associated with emergency department use among low-income children and whether any such association is mediated by household food hardship and child health status and/or moderated by special health care needs (SHCN) status. We hypothesized SNAP to be associated with reduced likelihoods of emergency department use, with greater effect sizes for children with SHCN and mediation by food hardship and health status.

METHODS
In this secondary analysis, we estimated a bivariate probit model (with state-level SNAP administrative policies as instruments) within a structural equation modeling framework using pooled cross-sectional samples of children in low-income households from the 2016 to 2019 iterations of the National Survey of Children’s Health (n = 24 990).

RESULTS
Among children with and without SHCN, respectively, SNAP was associated with: 22.0 percentage points (pp) (95% confidence interval [CI] 12.2–31.8pp) and 17.1pp (95% CI 7.2–27.0pp) reductions in the likelihood of household food hardship exposure (4.8pp difference-in-differences, 95% CI 2.3–7.4pp), 9.7pp (95% CI 3.9–15.5pp) and 7.9pp (95% CI 2.2–13.6) increases in the likelihood of excellent health status (1.9pp difference-in-differences, 95% CI 0.7–3.0pp), and 7.7pp (95% CI 2.9–12.5pp) and 4.3pp (95% CI 1.0–7.6pp) reductions in the likelihood of emergency department use (3.4pp difference-in-differences, 95% CI 1.8–5.1pp).

CONCLUSIONS
We found SNAP participation was associated with lower likelihoods of emergency department use, that better food hardship and health statuses mediated this association, and that effect sizes were larger among children with SHCN. Food hardship relief may improve outcomes for vulnerable children and the health systems serving them.
Effectiveness of the application of an educational program based on the Health Belief Model (HBM) in Adopting Preventive Behaviors from Self-Medication among Women in Iran. A rRandomized Controlled Trial
Authors: Movahed Ehsan , Rezaee Moradali Monireh , Saeed Jadgal Mohammad , Zareipour MoradAli , Tasouji Azari Mina 
Published: January 2023

Objective. To evaluate the effectiveness of the application of an educational program based on the Health Belief Model (HBM) in Adopting Preventive Behaviors from Self- Medication among Women in Iran.
Methods. Interventional study with pre and post phases. 200 women referring to the health centers of Urmia were selected by simple random sampling, divided into two groups of treatment and control. Data collection instruments were researcher- devised questionnaire including the questionnaire of Knowledge of Self-medication, the Questionnaire of Preventive Behaviors from Self medication, and the questionnaire of Health Belief Model. The questionnaires were assessed for expert validity and then, were checked for reliability. The educational intervention was conducted for the treatment group during four weeks four 45-minute sessions.
Results. The average scores of knowledge, perceived susceptibility, perceived severity, perceived benefits, perceived barriers, cues to action, self-efficiency, and post-intervention performance in have increased in treatment group, comparing to the control group, All findings were statistically significant (p<0.05). Furthermore, social media, doctors, and disbelief in self- medication were more effective in increasing awareness and encouraging to have proper medication, also, the highest self-medication was in taking pain-relievers, cold tablets and antibiotics, which showed significant decrease in treatment group after the intervention.
Conclusion. The educational program based on Health Belief Model was effective in reducing the self-medication among the studied women. Furthermore, it is recommended to use social media and doctors to improve the awareness and motivation among people. Thus, applying the educational programs and plans according to the Health Belief Model can be influential in reducing the self-medication.