bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise training promotes the immune cytotoxicity to enhance the inhibition of Doxorubicin in a Breast Cancer Model
Authors: Qin Bingqing , Gui Jianju , He Zhongshi , Xie Lixia , Feng Shenglan , Ye Junjie , Sun Xiaodong , Sang Ming 
Published: May 2023

Abstract
Background: Physical exercise is believed to play a vital role in the prevention and treatment of cancer and its complications. However, the molecular mechanisms underlying this effect remain unclear.
Methods: BALB/c female mice (n=24) were randomly divided into sedentary group (SED), exercise group (Ex), Doxorubicin group (Dox, 5 mg/kg), and Doxorubicin + exercise group (Dox + Ex) after 7 days of 4T1 cell implantation. Exercise training lasted for 28 days and included rotarod experiments and resistance training. H&E staining was used to observe histopathological changes in the tumor, spleen, and heart; The proportion of NK cells and T cells in peripheral and immune organs was analyzed by flow cytometry; The infiltration of NK and CD8 T cells and the expression levels of CD31 and VEGF in tumor tissues were evaluated by immunohistochemical; The mRNA expression levels of IL-6, IL-1β, TNF-α, TNF-α R, IFN-γ, and IFN-γ R were detected by q-PCR, and the protein expression levels of Bax, Bcl2 and cleaved caspase3 were detected by Western blot.
Results: The chemotherapeutic effect of Doxorubicin on breast cancer was significantly promoted by exercise training, and its mechanism might be that exercise activates the maturation of tumor killer cells in the immune system and releases tumor suppressor factors, such as TNF-α and IFN-γ, which induces the activation of Caspase3/Bax/Bcl2 signaling pathway in tumor cells.
Conclusions: It is suggested that exercise training improves chemotherapy efficacy while reducing side effects, which provides experimental evidence for the establishment of new clinical treatment strategies for breast cancer.
Clinical Outcomes of En-Bloc Cervical Laminoplasty for Cervical Spondylitic Myelopathy
Authors: Meral Mehmet 
Published: May 2023

Abstract
Objective Cervical spondylotic myelopathy (CSM) is one of the most serious complications of cervical spondylosis. The pattern, timing and outcomes of surgical treatment are controversial. Hirabayashi's hardware-assisted open-door laminoplasty method is currently frequently used in the surgical treatment of CSM. It is important to establish the timing, technique and results of surgery.Materials and Methods This study analyzed the preoperative and postoperative outcomes of 32 patients who underwent en-bloc cervical laminoplasty for CSM. The effect of preop symptom duration on post op clinical outcomes and the clinical outcomes of the surgical technique applied were evaluated. Modified Japanese Orthopedic Associatin (mJOA) score and Nurick scale were used for preop and postop functional and neurologic evaluation.Results The mean age of the patients was 63 ± 2years. Twenty-one patients were male (65.6%) and 11 were female (34.3%) and the mean follow-up period was 33 ± 4 months. Three patients had one level, 6 had two levels, 10 had three levels, and 13 had four levels of spinal stenosis. 7 of 8 patients with mJOA scores of 15 and above had complete recovery and one had partial benefit. Of the 10 patients with mJOA scores between 12 and 15, 7 had improved above 15 points and 3 had showed partial improvement. Of the 14 patients with a score below 12, 10 had improved to the 12–15 range, while 3 had remained unchanged. Deterioration had observed in one patientConclusion It was found that low mJOA score, high Nurick grade and long preoperative symptom duration negatively affected the surgical treatment results.
Cheese Intake and Infectious Diseases Risk: A Two-sample Mendelian randomization study
Authors: Teng Da , Li Jun , Zhang Shuaizhi , Zhang Xiaodong , Wu Ruijie 
Published: May 2023

Abstract
Introduction
Some beneficial effects of cheese intake on disease have been reported in several observational studies, However, there is still a gap in the study of infectious diseases. We aimed to apply the two-sample Mendelian randomization (MR) approach to assess the causal relationship between cheese intake and infectious diseases.
Methods
We used a two-sample Mendelian randomization approach to analyze relevant data from publicly available genome-wide association studies to infer causality. The random-effects inverse-variance-weighted method was used to calculate effect estimates.
Results
Genetically predicted cheese intake was associated with a lower risk of sepsis (OR = 0.63; 95% CI, 0.48–0.83; p = 0.003), pneumonia (OR = 0.67; 95% CI,0.55–0.82; p = 6.76 x10− 5), UTI(OR = 0.73; 95% CI, 0.61–0.89; p = 0.002), cellulitis ( OR = 0.70; 95%CI,0.51–0.91;p = 0.008) and erysipelas (OR = 0.62; 95% CI,0.46–0.83;p = 0.001). However, our results have no evidence to support the causal effects between cheese intake and URTI (OR = 0.81; 95% CI,0.47–1.39; p = 0.439). Multiple testing and sensitivity analyses demonstrate the reliability of our results.
Conclusion
In our MR study, we confirmed a causal relationship between cheese intake and infectious diseases. Although no evidence supports the causality of cheese intake in URTI, we also could show that an increased intake of cheese may be good for us to prevent infectious diseases.
The role of PMI in evaluating the efficacy of PD-1 inhibitors and prognosis of patients treated for advanced esophageal squamous cell carcinoma
Authors: Ge Lei , Sun Guoping , Li Hongxia , Wang Yi , Xu Yang , Wang Ziyong , Sun Feng 
Published: May 2023

Abstract
Background Skeletal muscle loss is an indicator of poor prognosis for various malignant tumours, including ESCC. We assessed whether the baseline psoas muscle mass index (PMI) could predict the response of ESCC to sintilimab treatment, with progression-free survival (PFS) and objective response rate (ORR) as the outcome measures.Methods A retrospective analysis of 51 patients with advanced ESCC who received immune checkpoint inhibitor (ICI) therapy. Efficacy was evaluated using immune response evaluation criteria in solid tumour (iRECIST), and the Kaplan‒Meier method was used to calculate the PFS and overall survival (OS). Univariate and multivariate Cox proportional hazards regression models were used to analyse prognostic factors.Results A total of 51 patients were included (1 immune complete response (iCR), 14 immune partial response (iPR), 28 immune stable disease (iSD), and 8 immune progressive disease (iPD). The overall ORR was 29.4%, and the disease control rate (DCR) was 84.3%. The ORR in the low PMI group was significantly lower than that in the high PMI group (21% vs. 53.8%). The median PFS was significantly prolonged in the high PMI group compared with that in the low PMI group (11.0 months vs. 6.0 months, HR = 2.796, 95% CI 1.262–6.198, p = 0.011). The median PFS was significantly prolonged in the high prognostic nutritional index (PNI) group compared with that in the low PNI group (10.0 months vs. 6.0 months, HR = 1.974, 95% CI 1.014–3.842, p = 0.045). The univariate analysis results indicated that low PMI and low PNI were poor prognostic factors for PFS (p < 0.05), and the multivariate Cox analysis results indicated that low PMI (HR = 2.588, 95% CI,1.163–5.758, p = 0.020) was an independent risk factor for PFS after immunotherapy for advanced ESCC.Conclusions The PMI can help predict the response to immunotherapy in patients with advanced ESCC.
The Remnant Cholesterol is associated with CVD incidence: A general population cohort study in Southwest China
Authors: Liu Chengxi , Dai Mi , Tian Kunming , Zhou Shiyu , Luo Lei , Zeng Zhiying , Yan Xuelian , Xiao Ying , Wang Yiying , Deng Renli , Lei Xiuhong , Liu Tao 
Published: May 2023

Abstract
Emerging evidence has indicated that remnant cholesterol (RC) could predict cardiovascular disease (CVD) incidence. Nevertheless, the relationship of RC with CVD risk, especially within the general Chinese population remains scarce. The purpose of the present research was to assess that RC concentrations and CVD outcomes in general Chinese adults are related. The Cox proportional hazard model was established to explore the relationship for RC and the outcomes of CVD and CVD subgroups. A restricted cubic spline (RCS) was utilized to investigate the dose-response connection between RC and the risk of CVD outcomes, and the ROC curve was used to calculate the corresponding cut-off values. Moreover, stratified analysis was carried out to investigate the potential effect modification in the association between RC and CVD outcomes. Significant positive associations were found between elevated categorical RC and increased risk of CVD (HR Q4, 1.80; 95% CI 1.15–2.79; P-trend = 0.008), Atherosclerotic cardiovascular disease (HR Q4, 2.00; 95% CI 1.22–3.27; P-trend = 0.007), Stroke (HR Q4, 1.66; 95% CI 1.02–2.69; P-trend = 0.040), and Ischemic stroke (HR Q4, 1.87, 95% CI 1.08–3.25; P-trend = 0.034), respectively. Our study suggested that the incidence of CVD outcomes increased when RC levels were above 0.75 mmol/L. Importantly, the CVD risks related with RC were more likely to be those aged＞60 years, females, BMI < 24 kg/m2, and who with hypertension and unhealthy diet patterns. In conclusion, aberrant high level of RC is associated with elevated CVD risk, and independent of low-density lipoprotein cholesterol (LDL-C). Our data reveal urgent primary prevention for subjects with high RC levels to low incidence of CVD, especially for the elderly, females, and those with hypertension and unhealthy diet patterns.
Developing the Queen Sense of the Visually Impaired: an Augent Task for Care Givers and Teachers of Young Learners With Visual Impairment
Authors: Mensah Prosper Anthony , Agbezudor Theresa , Gyamfi Abraham 
Published: May 2023

Abstract
The study is an action research which investigated the deficiency in listening skills exhibited by one pre-schooler with low vision at St. Joseph Practice School, Bechem, Ghana. It has the overriding goal of designing appropriate interventions to redress the identified gap. The study revealed that, listening does not develop automatically but deliberate and conscious training. The skills involved in listening were identified as awareness to the presence of sound, identifying the source of the sound, discriminating one sound from another and attaching meaning to what is heard. These are listening skills areas which may pose a challenge to pupils with visual impairment. To achieve the goal of the research, two sets of instruments were employed. Observation and interviews were used to collect data on the problem. Data collected on the problem was discussed, analyzed and presented on a table and a bar graph. It was found out that sound discrimination and sound comprehension are the listening skills areas pose a challenge to pupils with visual impairment and that there was an improvement in the performance across the various listening skill areas. It was recommended that younger children, especially the visually impaired, often times be taken on sound listening trips.
Comprehensive Transcriptome and Metabolome Analysis Reveals Regulatory Network for Lignin Biosynthesis in Chicory Sprouting
Authors: Li Juan , Guo Xiaozhu , Wang Gui , Zhou Zhenjie , Sun Xuemei 
Published: May 2023

Abstract
Purpose Chicory is consumed worldwide and is an important commercial crop. However, excess lignin deposition may reduce its quality. The molecular mechanisms underlying lignin remain poorly understood. To address this, an integrative analysis of the metabolome and transcriptome profiles was performed in chicory sprout at 3 different stages.Methods In this study, metabolites of the lignin biosynthesis pathway in chicory growth were determined by UPLC-MS/MS, moreover, multi-group sequencing and quantitative analysis of the transcriptome.Results A total of 706 metabolites were identified, with cinnamic acid, ferulic acid, Coniferaldehyde, and sinapaldehyde enriched during the growth of chicory sprouts. This suggested that these four metabolites may affect the growth of chicory sprouts. Transcriptome analysis demonstrated the expression of most of the differentially expressed genes (DEGs) involved in lignin biosynthesis was up-regulated during chicory growth.Conclusion Importantly, the metabolite and gene expression profiles were closely correlated during sprout development, especially in association with lignin biosynthesis. The results will serve as a reference for lignin biosynthesis in chicory and may also assist biologists in improving chicory quality.
Mobile Schwannoma of the Lumbar Spine: A Case Report and literature review
Authors: SONG Shaowen , LI Xiaojing , LYU Wanqiu , CHEN Liyuan , ZHANG Binqing 
Published: May 2023

Abstract
Background
Schwannoma is a benign tumor that originates from the cells of nerve sheaths. The occurrence of mobile schwannoma of the lumbar spine is extremely rare and has limited documentation in the literature. This report presents a case of mobile schwannoma in the lumbar spine.
Case Report
A 48-year-old male patient presented with a 2-year history of lower back pain and numbness in both lower extremities, which has progressively worsened over the past 3 months. An MRI scan revealed an oval-shaped lesion located in the L2/3 vertebral segment, which migrated to the L3/4 vertebral segment following contrast enhancement. The patient underwent tumor resection surgery, and the diagnosis of schwannoma was confirmed through pathological examination.
Conclusion
Clinical physicians should increase their understanding of mobile schwannoma of the lumbar spine and utilize imaging techniques to accurately locate the tumor before surgery, in order to avoid unnecessary surgical scope and the risks of additional surgery.
Online Diagnostic Method and System Design of Arc Plasma Jet Characteristics based on Wavelet Transform and Linear Regression Theory
Authors: Cao Xiuquan , Guo Wenyu , He Yong , Huang Bo , Wang Lin , Liu Yuzhe 
Published: May 2023

Abstract
For monitoring the online jet characteristics and improving the corresponding diagnostic accuracy, caused by the complex working environment of arc plasma generation systems, an online diagnostic method of arc plasma jet characteristics based on wavelet transform and linear regression theory was proposed. The wavelet denoising to improve the accuracy of plasma jet characteristics and the linear regression theory to predict the plasma arc voltage characteristics have been discussed. Hence, a comprehensive online diagnostic system of plasma jet characteristics has been designed by integrating the proposed method with LabVIEW virtual instrument technology. To verify the effectiveness of the online diagnostic method and system, the corresponding experiments have been conducted by using a homemade plasma generation system with specified working parameters. Sequence, the experimental results have been analyzed and discussed. The experimental results show that: ① the proposed online diagnostic method based on wavelet transform and linear regression theory could effectively improve the accuracy and predict the jet characteristics of plasma jets; ② the online jet characteristics of thermal plasma jet could be monitored by using the corresponding diagnostic system.
Efficient and simultaneous immobilization of fluoride and lead in water and tea garden soil by bayberry tannin foam loaded zirconium
Authors: Huang Xiaolu , Zhang Mei , Wang Minghui , Wen Zhuoyu , Jiang Yamei , Sui Yunhao , Li Xiaoting , Ma Jun , Liao Yang 
Published: May 2023

Abstract
Human activities have led to various pollution in the environment, and the combined pollution of fluoride and lead in acidic tea garden soil has received much attention. The key to eliminating this combined pollution is to immobilize pollutants simultaneously, thus preventing their migration from tea garden soil to tea trees. In this paper, the natural product bayberry tannin was employed as raw material to fabricate functional materials (TF-Zr) for simultaneous adsorption of fluorine (F) and lead (Pb) in water and soil by the reactivity of tannin with Pb2+ and the affinity of Zr with F. The characterization techniques such as SEM-Mapping, EDS, FT-IR, XPS were utilized to probe the adsorption mechanism. The results showed that TF-Zr could simultaneously and efficiently adsorb F− and Pb2+ with the adsorption capacity of 5.02 mg/g (Pb) and 4.55 mg/g (F), and the adsorption processes were both in accordance with the proposed secondary kinetic adsorption model. Besides, the presence of F− promoted the adsorption of Pb2+ by TF-Zr. The materials were applied into the tea garden soil to explore its effect on the variation of F and Pb forms in tea garden soil. It was found that the proportion of water-soluble fluorine, exchangeable fluorine and exchangeable lead in the tea garden soil decreased significantly, while the proportion of residual fluorine and residual lead increased evidently, illustrating TF-Zr possessed eximious fixation effect on the highly reactive fluorine and lead in the soil and facilitated their conversion to the more stable residue state. Therefore, TF-Zr can be used for the efficient and simultaneous immobilization of fluorine and lead in water and tea garden soil.
The effect of tDCS on mind wandering in adults with and without ADHD:
Authors: Nejati Vahid , Majidinezhad Maryam , Yavari Fateme , Nitsche Michael 
Published: May 2023

Abstract
Objective Individuals with attention deficit- hyperactivity disorder (ADHD) have a higher propensity to mind wandering. The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC), which show reduced functionality in individuals with ADHD, are involved in mind wandering.Methods Forty adults with or without ADHD received transcranial direct current stimulation (tDCS) in three different conditions including anodal left dlPFC/cathodal right vmPFC stimulation, the reversed montage, and a sham stimulation. During stimulation, in each session, participants performed the sustained attention to response task as a measure of attentional performance, and a task-unrelated thoughts task to monitor mind wandering.Results A significant main effect of stimulation condition was identified for attentional performance and task-unrelated thoughts. Anodal left dlPFC coupled with cathodal right vmPFC stimulation improved attention task performance and reduced mind wandering. Furthermore, higher baseline mind wandering and ADHD scores independent from the diagnostic group were associated with larger beneficial effects of tDCS on mind wandering.Conclusion These results described the role of the left dlPFC and the right vmPFC on attentional performance and mind wandering in adults with and without ADHD. tDCS had beneficial effects on mind wandering, and attention with simultaneous anodal left dlPFC and cathodal right vmPFC stimulation, and the size of the effects on mind wandering depended on mind wandering before intervention, and ADHD scores.
Bioassay-guided purification of α-glucosidase inhibitor fatty acids from Padina tetrastromatica
Authors: Moheimanian Nioofar , Mirkhani Hossein , Edraki Najmeh , Poustforoosh Alireza , Momeni Safieh , Khalighian Najmeh , Zidorn Christian , Sohrabipour Jelveh , Jassbi Amir Reza 
Published: May 2023

Abstract
Anti-diabetic potential of a brown alga, Padina tetrastromatica, from the coastline of the Persian Gulf, using bioassay-guided purification approach yielded the most active α-glucosidase inhibitor agents as fatty acids. Initially, the yeast’s α-glucosidase inhibition of the MeOH and 80% MeOH extracts were evaluated via a colorimetric assay. The liquid-liquid fractionation of 80% MeOH extract, as the most potent α-glucosidase inhibitor, resulted in four fractions, n-hexane, ethyl acetate, n-butanol and water. Hexane and ethyl acetate fractions were selected for further studies, with the IC50 values of 38.0 ± 0.3 µg/mL and 53.7 ± 2.6 µg/mL, respectively. Followed by investigating α-glucosidase inhibition of the sub-fractions from the hexane fraction, using flash column chromatography, F18-21 selected as the most potent enzyme inhibitor. After further purifications of F18-21 by semi preparative HPLC, the mentioned fraction and two purified compounds, 8-octadecenoic acid (8) and all-cis-5,8,11,14-eicosatetraenoic acid (10) were subjected to GC-MS analysis for the identification. In addition, 1D and 2D NMR evaluations were performed for characterisation of 8-octadecenoic acid. Furthermore, three fatty acids, all-cis-8,11,14,17-eicosatetraenoic acid (6), cis-9,12-octadecadienoic acid (7), and all-cis-5,8,11,14,17-eicosapentaenoic acid (11), were isolated from the ethyl acetate fraction and identified, by HPLC and GC-MS techniques, respectively. Finally, α-glucosidase inhibition percent of the purified fatty acids were evaluated in two concentrations in the microplates, which showed their great potential for further investigations as anti-diabetic agents, in comparison with acarbose, as the positive control. Furthermore, molecular docking analysis and MD simulation were applied to investigate the structure activity of the purified compounds.
Multi-Stimuli-Responsive Biocompatible Magnetic Nanocarrier as Drug delivery System to MC7 Breast Cancer Cells
Authors: Ehsanimehr Sedigheh , Moghadam Peyman Najafi , Dehaen Wim , Shafiei-Irannejad Vahid 
Published: May 2023

Abstract
Efforts are ongoing to develop effective controlled-release therapeutic systems through innovative functional targeted drug delivery systems (TDDS). Functional polymeric nanocarriers are crucial in delivering therapeutic drugs efficiently into tumors. This study designed a redox/pH-responsive functional drug delivery platform with ligands for targeting MC7 breast cancer cells using a core-shell biocompatible magnetic nanocarrier. The process involved synthesizing oleic acid-coated Fe3O4@SiO2 nanoparticles, modifying pluronic F127 (PF 127) with maleic anhydride and aminating it to form PF127-NH2, linking L-cysteine to PF127-NH2, and condensing carboxymethyl-β-cyclodextrin (CM-β-CD) to PF127-NH2/L-cysteine, which was targeted by folic acid (FA). The resulting PF127-NH2/L-cysteine-CM-β-CD-FA formed LCMNPs-SS in the presence of oleic acid-coated Fe3O4@SiO2. Doxorubicin (DOX) was used as a model drug and loaded into the LCMNPs-SS nanocarrier. The LCMNPs-SS nanocarrier exhibited excellent properties for controlled release, with release rate and level controllable by adding an external magnet and adjusting the DTT concentration. Additionally, the LCMNPs-SS nanocarrier could disassemble under the effects of oxidant or pH, allowing for fine-tuning of drug release in response to temperature and pH or multiple stimuli.