bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-neuron mechanisms of neural adaptation in the human temporal lobe
Authors: Reber Thomas P. , Mackay Sina , Bausch Marcel , Kehl Marcel S. , Borger Valeri , Surges Rainer , Mormann Florian 
Published: April 2023

AbstractA central function of the human brain is to adapt to new situations based on past experience. Adaptation is reflected behaviorally by shorter reaction times to repeating or similar stimuli, and neurophysiologically by reduced neural activity in bulk-tissue measurements with fMRI or EEG. Several potential single-neuron mechanisms have been hypothesized to cause this reduction of activity at the macroscopic level. We here explore these mechanisms using an adaptation paradigm with visual stimuli bearing abstract semantic similarity. We recorded intracranial EEG (iEEG) simultaneously with spiking activity of single neurons in the medial temporal lobes of 25 neurosurgical patients. Recording from 4917 single neurons, we demonstrate that reduced event-related potentials in the macroscopic iEEG signal are associated with a sharpening of single-neuron tuning curves in the amygdala, but with an overall reduction of single-neuron activity in the hippocampus, entorhinal cortex, and parahippocampal cortex, consistent with fatiguing in these areas.
Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis
Authors: Jia Yuanbo , Hu Jiahui , An Keli , Zhao Qiang , Dang Yang , Liu Hao , Wei Zhao , Geng Songmei , Xu Feng 
Published: April 2023

AbstractAtopic dermatitis (AD) is a chronic skin disease caused by skin immune dyshomeostasis and accompanied by severe pruritus. Although oxidative stress and mechanical scratching can aggravate AD inflammation, treatment targeting scratching is often overlooked, and the efficiency of mechano-chemically synergistic therapy remains unclear. Here, we find that enhanced phosphorylation of focal adhesion kinase (FAK) is associated with scratch-exacerbated AD. We then develop a multifunctional hydrogel dressing that integrates oxidative stress modulation with FAK inhibition to synergistically treat AD. We show that the adhesive, self-healing and antimicrobial hydrogel is suitable for the unique scratching and bacterial environment of AD skin. We demonstrate that it can scavenge intracellular reactive oxygen species and reduce mechanically induced intercellular junction deficiency and inflammation. Furthermore, in mouse AD models with controlled scratching, we find that the hydrogel alleviates AD symptoms, rebuilds the skin barrier, and inhibits inflammation. These results suggest that the hydrogel integrating reactive oxygen species scavenging and FAK inhibition could serve as a promising skin dressing for synergistic AD treatment.
Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation
Authors: Yang Wei , Liu Li-Bo , Liu Feng-Liang , Wu Yan-Hua , Zhen Zi-Da , Fan Dong-Ying , Sheng Zi-Yang , Song Zheng-Ran , Chang Jia-Tong , Zheng Yong-Tang , An Jing , Wang Pei-Gang 
Published: April 2023

AbstractZika virus (ZIKV) is a potential threat to male reproductive health but the mechanisms underlying its influence on testes during ZIKV infection remain obscure. To address this question, we perform single-cell RNA sequencing using testes from ZIKV-infected mice. The results reveal the fragility of spermatogenic cells, especially spermatogonia, to ZIKV infection and show that the genes of the complement system are significantly upregulated mainly in infiltrated S100A4 + monocytes/macrophages. Complement activation and its contribution to testicular damage are validated by ELISA, RT‒qPCR and IFA and further verify in ZIKV-infected northern pigtailed macaques by RNA genome sequencing and IFA, suggesting that this might be the common response to ZIKV infection in primates. On this basis, we test the complement inhibitor C1INH and S100A4 inhibitors sulindac and niclosamide for their effects on testis protection. C1INH alleviates the pathological change in the testis but deteriorates ZIKV infection in general. In contrast, niclosamide effectively reduces S100A4 + monocyte/macrophage infiltration, inhibits complement activation, alleviates testicular damage, and rescues the fertility of male mice from ZIKV infection. This discovery therefore encourages male reproductive health protection during the next ZIKV epidemic.
Anomalous enhancement of charge density wave in kagome superconductor CsV3Sb5 approaching the 2D limit
Authors: Song Boqin , Ying Tianping , Wu Xianxin , Xia Wei , Yin Qiangwei , Zhang Qinghua , Song Yanpeng , Yang Xiaofan , Guo Jiangang , Gu Lin , Chen Xiaolong , Hu Jiangping , Schnyder Andreas P. , Lei Hechang , Guo Yanfeng , Li Shiyan 
Published: April 2023

AbstractThe recently discovered kagome metals AV3Sb5 (A = Cs, Rb, K) exhibit a variety of intriguing phenomena, such as a charge density wave (CDW) with time-reversal symmetry breaking and possible unconventional superconductivity. Here, we report a rare non-monotonic evolution of the CDW temperature (TCDW) with the reduction of flake thickness approaching the atomic limit, and the superconducting transition temperature (Tc) features an inverse variation with TCDW. TCDW initially decreases to a minimum value of 72 K at 27 layers and then increases abruptly, reaching a record-high value of 120 K at 5 layers. Raman scattering measurements reveal a weakened electron-phonon coupling with the reduction of sample thickness, suggesting that a crossover from electron-phonon coupling to dominantly electronic interactions could account for the non-monotonic thickness dependence of TCDW. Our work demonstrates the novel effects of dimension reduction and carrier doping on quantum states in thin flakes and provides crucial insights into the complex mechanism of the CDW order in the family of AV3Sb5 kagome metals.
Regulating the electronic structure through charge redistribution in dense single-atom catalysts for enhanced alkene epoxidation
Authors: Jin Hongqiang , Zhou Kaixin , Zhang Ruoxi , Cui Hongjie , Yu Yu , Cui Peixin , Song Weiguo , Cao Changyan 
Published: April 2023

AbstractInter-site interaction in densely populated single-atom catalysts has been demonstrated to have a crucial role in regulating the electronic structure of metal atoms, and consequently their catalytic performances. We herein report a general and facile strategy for the synthesis of several densely populated single-atom catalysts. Taking cobalt as an example, we further produce a series of Co single-atom catalysts with varying loadings to investigate the influence of density on regulating the electronic structure and catalytic performance in alkene epoxidation with O2. Interestingly, the turnover frequency and mass-specific activity are significantly enhanced by 10 times and 30 times with increasing Co loading from 5.4 wt% to 21.2 wt% in trans-stilbene epoxidation, respectively. Further theoretical studies reveal that the electronic structure of densely populated Co atoms is altered through charge redistribution, resulting in less Bader charger and higher d-band center, which are demonstrated to be more beneficial for the activation of O2and trans-stilbene. The present study demonstrates a new finding about the site interaction in densely populated single-atom catalysts, shedding insight on how density affects the electronic structure and catalytic performance for alkene epoxidation.
Psychological proximity improves reasoning in academic aptitude tests
Authors: Hadar Britt , Katzir Maayan , Pumpian Sephi , Karelitz Tzur , Liberman Nira 
Published: April 2023

AbstractPerformance on standardized academic aptitude tests (AAT) can determine important life outcomes. However, it is not clear whether and which aspects of the content of test questions affect performance. We examined the effect of psychological distance embedded in test questions. In Study 1 (N = 41,209), we classified the content of existing AAT questions as invoking proximal versus distal details. We found better performance with proximal compared to distal questions, especially for low-achieving examinees. Studies 2 and 3 manipulated the distance of questions adapted from AATs and examined three moderators: overall AAT score, working-memory capacity, and presence of irrelevant information. In Study 2 (N = 129), proximity (versus distance) improved the performance of low-achieving participants. In Study 3 (N = 1744), a field study, among low-achieving examinees, proximity improved performance on questions that included irrelevant information. Together, these results suggest that the psychological distance that is invoked by the content of test questions has important consequences for performance in real-life high-stakes tests.
Bifurcation analysis of hepatitis B virus with non-cytolytic cure process on infected liver and blood cells
Authors: Mamo Tesfaye Tefera 
Published: April 2023

AbstractThe phenomenon of bifurcation in disease transmission models has been observed in a number of epidemiological models. The consequence of bifurcation is that the classical requirement of the reproduction number being less than unity becomes only a necessary, but not sufficient, for disease elimination. This paper addresses the problem of finding the causes of bifurcation in standard deterministic models for the spread of HBV diseases with non-Cytolytic cure processes on infected liver and blood cells. The model contains logistic growth of healthy liver and blood cells and non -Cytolytic cure processes of infected cells. I have got that the model exhibits back ward and forward bifurcations with some conditions. The existence of a backward bifurcation is an interesting artifact since this means that the disease cannot be eradicated by simply reducing the value of the basic reproduction number$${R}_{0}$$R0below 1.This can have important implications on drug therapy protocols, since it sheds light on possible control mechanisms for disease eradication.
Comparison of postoperative outcomes between bikini-incision via direct anterior approach and posterolateral approach in simultaneous bilateral total hip arthroplasty: a randomized controlled trial
Authors: Jin Xin , Chen Guo , Chen Mengcun , Riaz Muhammad N. , Wang Jing , Yang Shuhua , Xu Weihua 
Published: April 2023

AbstractThe purpose of this study was to compare an oblique bikini-incision via direct anterior approach (BI-DAA) to a conventional posterolateral approach (PLA) during simultaneous bilateral total hip arthroplasty (simBTHA) in terms of early patient outcomes, postoperative functional recovery, and complications. From January 2017 to January 2020, 106 patients receiving simBTHA were enrolled and randomly allocated to the BI-DAA or PLA group. Primary outcomes were measured using hemoglobin (HGB) drop, transfusion rate, the length of stay (LOS), the visual analog scale (VAS) for pain, the Harris hip score, Western Ontario and McMaster Universities Osteoarthritis Index, and the scar cosmesis assessment and rating scale. Secondary outcomes were the operative time, radiographic measurements, including femoral offset, femoral anteversion, stem varus/valgus angle, and leg length discrepancy (LLD). The occurrence of postoperative complications was also recorded. There were no differences in demographic or clinical characteristics before surgery. Compared to the PLA, the patients in the BI-DAA group had lower HGB drop (24.7 ± 13.3 g/L vs. 34.7 ± 16.7, P < .01) and transfusion rates (9/50 vs. 18/50, P = .04) and a shorter LOS (5.12 ± 1.5 vs. 6.40 ± 2.0 days, P < .01) without increasing the operative time (169.7 ± 17.3 vs. 167.5 ± 21.8 min, P = .58). The BI-DAA group yielded a smaller LLD (2.1 ± 2.3 vs. 3.8 ± 3.0 mm, P < .01) and less variability in component orientation than the PLA group (100% vs. 93%, P = .01). As for the scar, the BI-DAA group produced a shorter incision length (9.7 ± 1.6 vs. 10.8 ± 2.0 mm, P < .01) and higher postoperative recovery satisfaction than the PLA group. Furthermore, the BI-DAA group had a reduced VAS score one week after surgery and had better functional recovery in three months postoperatively. The BI-DAA group had a higher incidence of LFCN dysesthesia (12/100 vs. 0/100 thighs, P < .01), while other complications did not differ significantly between the two groups. For simBTHA, the bikini incision offers early recovery, less variance in components orientation, better postoperative outcomes, and scar healing than the PLA. Therefore, the bikini incision could be a safe and feasible option for simBTHA recipients.
Personalized prediction of one-year mental health deterioration using adaptive learning algorithms: a multicenter breast cancer prospective study
Authors: Kourou Konstantina , Manikis Georgios , Mylona Eugenia , Poikonen-Saksela Paula , Mazzocco Ketti , Pat-Horenczyk Ruth , Sousa Berta , Oliveira-Maia Albino J. , Mattson Johanna , Roziner Ilan , Pettini Greta , Kondylakis Haridimos , Marias Kostas , Nuutinen Mikko , Karademas Evangelos , Simos Panagiotis , Fotiadis Dimitrios I. 
Published: April 2023

AbstractIdentifying individual patient characteristics that contribute to long-term mental health deterioration following diagnosis of breast cancer (BC) is critical in clinical practice. The present study employed a supervised machine learning pipeline to address this issue in a subset of data from a prospective, multinational cohort of women diagnosed with stage I–III BC with a curative treatment intention. Patients were classified as displaying stable HADS scores (Stable Group; n = 328) or reporting a significant increase in symptomatology between BC diagnosis and 12 months later (Deteriorated Group; n = 50). Sociodemographic, life-style, psychosocial, and medical variables collected on the first visit to their oncologist and three months later served as potential predictors of patient risk stratification. The flexible and comprehensive machine learning (ML) pipeline used entailed feature selection, model training, validation and testing. Model-agnostic analyses aided interpretation of model results at the variable- and patient-level. The two groups were discriminated with a high degree of accuracy (Area Under the Curve = 0.864) and a fair balance of sensitivity (0.85) and specificity (0.87). Both psychological (negative affect, certain coping with cancer reactions, lack of sense of control/positive expectations, and difficulties in regulating negative emotions) and biological variables (baseline percentage of neutrophils, thrombocyte count) emerged as important predictors of mental health deterioration in the long run. Personalized break-down profiles revealed the relative impact of specific variables toward successful model predictions for each patient. Identifying key risk factors for mental health deterioration is an essential first step toward prevention. Supervised ML models may guide clinical recommendations toward successful illness adaptation.
The $$^{1}\!S_{0}$$ channel of proton–proton scattering in new chiral effective field theory power counting
Authors: Behzadmoghaddam B. , Radin M. , Bayegan S. 
Published: April 2023

AbstractIn this paper, the chiral effective field theory is used to investigate the spin singlet channel $$^{1\!}S_{0}$$

1

S
0

, of proton-proton (pp) scattering according to the new suggested power counting. For this purpose, the pp zero scattering amplitude is reproduced by inserting one pion exchange at leading order (LO) and the Coulomb interaction between protons at next-to-leading order (NLO). This leads to a systematic improvement up to NLO compared to the result obtained from Nijm93 potential model.
mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin
Authors: Chantaravisoot Naphat , Wongkongkathep Piriya , Kalpongnukul Nuttiya , Pacharakullanon Narawit , Kaewsapsak Pornchai , Ariyachet Chaiyaboot , Loo Joseph A. , Tamanoi Fuyuhiko , Pisitkun Trairak 
Published: April 2023

AbstractmTOR complex 2 (mTORC2) has been implicated as a key regulator of glioblastoma cell migration. However, the roles of mTORC2 in the migrational control process have not been entirely elucidated. Here, we elaborate that active mTORC2 is crucial for GBM cell motility. Inhibition of mTORC2 impaired cell movement and negatively affected microfilament and microtubule functions. We also aimed to characterize important players involved in the regulation of cell migration and other mTORC2-mediated cellular processes in GBM cells. Therefore, we quantitatively characterized the alteration of the mTORC2 interactome under selective conditions using affinity purification-mass spectrometry in glioblastoma. We demonstrated that changes in cell migration ability specifically altered mTORC2-associated proteins. GSN was identified as one of the most dynamic proteins. The mTORC2-GSN linkage was mostly highlighted in high-grade glioma cells, connecting functional mTORC2 to multiple proteins responsible for directional cell movement in GBM. Loss of GSN disconnected mTORC2 from numerous cytoskeletal proteins and affected the membrane localization of mTORC2. In addition, we reported 86 stable mTORC2-interacting proteins involved in diverse molecular functions, predominantly cytoskeletal remodeling, in GBM. Our findings might help expand future opportunities for predicting the highly migratory phenotype of brain cancers in clinical investigations.
Enriched environment exposure during development positively impacts the structure and function of the visual cortex in mice
Authors: Bibollet-Bahena O. , Tissier S. , Ho-Tran S. , Rojewski A. , Casanova C. 
Published: April 2023

AbstractOptimal conditions of development have been of interest for decades, since genetics alone cannot fully explain how an individual matures. In the present study, we used optical brain imaging to investigate whether a relatively simple enrichment can positively influence the development of the visual cortex of mice. The enrichment paradigm was composed of larger cages housing multiple mice that contained several toys, hiding places, nesting material and a spinning wheel that were moved or replaced at regular intervals. We compared C57BL/6N adult mice (> P60) that had been raised either in an enriched environment (EE; n = 16) or a standard (ST; n = 12) environment from 1 week before birth to adulthood, encompassing all cortical developmental stages. Here, we report significant beneficial changes on the structure and function of the visual cortex following environmental enrichment throughout the lifespan. More specifically, retinotopic mapping through intrinsic signal optical imaging revealed that the size of the primary visual cortex was greater in mice reared in an EE compared to controls. In addition, the visual field coverage of EE mice was wider. Finally, the organization of the cortical representation of the visual field (as determined by cortical magnification) versus its eccentricity also differed between the two groups. We did not observe any significant differences between females and males within each group. Taken together, these data demonstrate specific benefits of an EE throughout development on the visual cortex, which suggests adaptation to their environmental realities.
Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation
Authors: Hanyuda Akiko , Goto Atsushi , Katagiri Ryoko , Koyanagi Yuriko N. , Nakatochi Masahiro , Sutoh Yoichi , Nakano Shiori , Oze Isao , Ito Hidemi , Yamaji Taiki , Sawada Norie , Iwagami Masao , Kadota Aya , Koyama Teruhide , Katsuura-Kamano Sakurako , Ikezaki Hiroaki , Tanaka Keitaro , Takezaki Toshiro , Imoto Issei , Suzuki Midori , Momozawa Yukihide , Takeuchi Kenji , Narita Akira , Hozawa Atsushi , Kinoshita Kengo , Shimizu Atsushi , Tanno Kozo , Matsuo Keitaro , Tsugane Shoichiro , Wakai Kenji , Sasaki Makoto , Yamamoto Masayuki , Iwasaki Motoki 
Published: April 2023

AbstractObservational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide associations of fasting glucose (~ 17,289 individuals), HbA1c (~ 52,802 individuals), and fasting C-peptide (1,666 individuals) levels from the Japanese Consortium of Genetic Epidemiology studies. The odds ratios of colorectal cancer were 1.01 (95% confidence interval [CI], 0.99–1.04, P = 0.34) for fasting glucose (per 1 mg/dL increment), 1.02 (95% CI, 0.60–1.73, P = 0.95) for HbA1c (per 1% increment), and 1.47 (95% CI, 0.97–2.24, P = 0.06) for fasting C-peptide (per 1 log increment). Sensitivity analyses, including Mendelian randomisation-Egger and weighted-median approaches, revealed no significant association between glycaemic characteristics and colorectal cancer (P > 0.20). In this study, genetically predicted glycaemic characteristics were not significantly related to colorectal cancer risk. The potential association between insulin resistance and colorectal cancer should be validated in further studies.
Human health-risk assessment of heavy metal–contaminated soil based on Monte Carlo simulation
Authors: Panqing Ye , Abliz Abdugheni , Xiaoli Sun , Aisaiduli Halidan 
Published: April 2023

AbstractSoil contamination soils of by heavy metals (HMs) poses serious threats to the soil environment and enters the human body through exposure pathways such as ingestion and skin contact, posing a threat to human health. The purpose of this study was to analyze the sources and contributions of soil HMs, and to quantitatively assess the human health risks of soil HMs to different populations (i.e. children, adult females and adult males), and to analyze the human health risks caused by various sources of sensitive populations. 170 topsoil (0–20 cm) were collected from Fukang, Jimsar and Qitai on the northern slope of Tianshan Mountains in Xinjiang, China, and the contents of Zn, Cu, Cr, Pb and Hg were determined. This study used the Unmix model and a health-risk assessment (HRA) model to assess the human health risks of five HMs. The results showed that: (1) The mean values of Zn and Cr were lower than the background values of Xinjiang, the mean values of Cu and Pb were slightly higher than the background values of Xinjiang but lower than the national standard, and the mean value of Hg and Pb was higher than the background value of Xinjiang and the national standard. (2) The sources of soil HMs in the region were mainly traffic, natural, coal, and industrial sources. Moreover, the HRA model combined with Monte Carlo simulation showed similar trends in the health-risk status of all population groups in the region. Probabilistic HRA revealed that noncarcinogenic risks were acceptable for all populations (HI < 1) while carcinogenic risks were high (children: 77.52%; female: 69.09%; male: 65.63%). For children, carcinogenic risk from industrial and coal sources exceeded the acceptable threshold by 2.35 and 1.20 times, respectively, and Cr was the main element contributing to human carcinogenic risk. These findings suggest that carcinogenic risks from coal-based Cr emissions cannot be ignored, and the study area should aim to control Cr emissions from industrial sources. The results of this study provide support for the prevention of human health risks and the control of soil HMs pollution across different age groups.