bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced bone formation and increased bone resorption drive bone loss in Eimeria infected broilers
Authors: Tompkins Yuguo Hou , Choi Janghan , Teng Po-Yun , Yamada Masayoshi , Sugiyama Toshie , Kim Woo Kyun 
Published: January 2023

AbstractCoccidiosis is an economically significant disease in the global poultry industry, but little is known about the mechanisms of bone defects caused by coccidiosis; thus, the study focused on effects of coccidiosis on the bone homeostasis of young broiler chickens. A total of 480 male Cobb500 broilers were randomly allocated into four treatment groups, including an uninfected control consuming diet ad libitum, two infected groups were orally gavaged with two different concentrations of sporulated Eimeria oocysts, and an uninfected pair-fed group fed the same amount of feed as the high Eimeria-infected group consumed. Growth performance and feed intake were recorded, and samples were collected on 6 days post infection. Results indicated that coccidiosis increased systemic oxidative status and elevated immune response in bone marrow, suppressing bone growth rate (P < 0.05) and increasing bone resorption (P < 0.05) which led to lower bone mineral density (P < 0.05) and mineral content (P < 0.05) under Eimeria infection. With the same amount of feed intake, the uninfected pair-fed group showed a distinguished bone formation rate and bone resorption level compared with the Eimeria infected groups. In conclusion, inflammatory immune response and oxidative stress in broilers after Eimeria infection were closely associated with altered bone homeostasis, highlighting the role of inflammation and oxidative stress in broiler bone homeostasis during coccidiosis.
Non-ergodic extended regime in random matrix ensembles: insights from eigenvalue spectra
Authors: Xu Wang-Fang , Rao W. J. 
Published: January 2023

AbstractThe non-ergodic extended (NEE) regime in physical and random matrix (RM) models has attracted a lot of attention in recent years. Formally, NEE regime is characterized by its fractal wavefunctions and long-range spectral correlations such as number variance or spectral form factor. More recently, it’s proposed that this regime can be conveniently revealed through the eigenvalue spectra by means of singular-value-decomposition (SVD), whose results display a super-Poissonian behavior that reflects the minibands structure of NEE regime. In this work, we employ SVD to a number of RM models, and show it not only qualitatively reveals the NEE regime, but also quantitatively locates the ergodic-NEE transition point. With SVD, we further suggest the NEE regime in a new RM model–the sparse RM model.
Measure and spatial identification of social vulnerability, exposure and risk to natural hazards in Japan using open data
Authors: Raduszynski Theo , Numada Muneyoshi 
Published: January 2023

AbstractUnderstanding the location of risk to natural hazards, namely the areas of high exposure and vulnerability is a major priority that was identified by the Sendai framework for Disaster Reduction 2015–2030 in order to reach substantial reduction of disaster risk. It is also a necessary decision-making tool for disaster mitigation policy-makers in Japan and around the world. This paper successfully develops a simple methodology using only open data to build the first large-scale (whole country), fine resolution (sub-municipal level) social vulnerability analysis in the context of five different types of natural hazards (earthquake, tsunami, storm surge, flooding and landslide). The result is then compared to an indicator of exposure of population to these hazards in Japan in order to propose a representation of disaster risk. Results show that vulnerability in Japan is highly heterogeneous with urban/rural and north/south fractures. Combining the social vulnerability index with exposure analysis, results show a wide variety of spatial patterns of risk areas in Japan.
The negative association between serum albumin levels and coronary heart disease risk in adults over 45 years old: a cross-sectional survey
Authors: Hou Xin-zheng , Liu En-qi , Liu Si-qi , Lv Hao , Cui Hua-feng , Han Jing 
Published: January 2023

AbstractThis study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. This cross-sectional study used the non-institutionalized US population from the National Health and Nutrition Examination Survey (NHANES 2011–2018) as the sample source. Multiple logistic regression was performed to evaluate the association between serum albumin levels and CHD risk. Smooth curve fitting was performed to explore potential nonlinear relationships. When nonlinear relationships were found, a recursive algorithm was used to calculate inflection points. Additionally, a piecewise logistic regression model was constructed. After adjusting for confounders, multiple logistic regression and smooth curve fitting indicated an inverse association between serum albumin levels and CHD risk [OR = 0.970, 95% CI = (0.948, 0.992)]. Subgroup analysis revealed that the negative correlation was statistically significant in the population of female patients, over 60 years, with hypertension, without diabetes. There was a correlation between serum albumin levels and CHD risk. Lower serum albumin levels were associated with a higher CHD risk.
Long-term Outcomes of Submacular Perfluorocarbon Liquid Removal with Internal Limiting Membrane Peeling and Transretinal Aspiration
Authors: Ilhan Cagri , Horozoglu Ceran Tugce , Citirik Mehmet , Teke Mehmet Yasin 
Published: January 2023

Abstract
Background An important complication associated with perfluorocarbon liquid (PFCL) use during pars plana vitrectomy (PPV) is its retention in the submacular area. The aim of this
study was to present the long-term outcomes of the surgical method used in this study to remove submacular PFCL and to shed light on the advantages and disadvantages compared to other
methods.
Material and Methods This is a retrospective, single-center, observational study. Patients who underwent surgical intervention due to submacular PFCL were included in this study. The
surgical procedural includes internal limiting membrane (ILM) peeling, transretinal aspiration of submacular PCFL with a 25/27-gauge soft-tipped cannula, then perfluoropropane
(C3F8) gas tamponade, and facedown positioning for 5 days. The long-term anatomical and functional outcomes were evaluated with an ophthalmological examination and
optical coherence tomography (OCT).
Outcomes A total of 15 patients with submacular PFCL were included in this study, and the mean age of the patients was 64.33 ± 10.36 years (47 – 83). The localization of submacular
PFCL was subfoveal in nine patients (60.00%), non-subfoveal in four patients (26.67%), and both subfoveal and non-subfoveal in two patients (13.33%). The mean time of submacular PFCL
diagnosis was 4.86 ± 1.02 weeks (2 – 8) and the mean time of the surgery was 9.80 ± 1.17 weeks (8 – 14). Complete removal of submacular PFCL was achieved in all cases (100%) and no
significant treatment-associated complications were observed. The mean follow-up time was 37.60 ± 14.00 months (18 – 60) and the best-corrected visual acuity was significantly improved
(p = 0.001). At the end of the follow-up time, prominent ellipsoid zone disruption was observed in six patients (40.00%), while in nine patients (60.00%), there was no prominent ellipsoid
zone disruption.
Conclusions The surgical procedural for submacular PFCL removal is a reasonable option and improves visual acuity in the long term without any significant treatment-associated
complications.
Implementation of an Epidural Rounding Reminder in the Electronic Medical Record Improves Performance of Standardized Patient Assessments during Labor
Authors: Ende Holly B. , French Benjamin , Shi Yaping , Damron James , Bauchat Jeanette R. , Dumas Susan , Wanderer Jonathan P. 
Published: January 2023

Abstract
Background Poorly functioning labor epidural catheters lead to pain and dissatisfaction. Regular catheter assessment ensures timely identification of malfunction and may improve safety by facilitating rapid and successful conversion to general anesthesia for emergency cesarean. Informatics-based systems encourage standardization of care to identify epidural malfunctions earlier.
Objectives This article demonstrates that visual epidural rounding reminder display on an electronic patient board would alert clinicians to elapsed time and decrease mean time between assessments.
Methods As a quality initiative, we implemented an epidural rounding reminder on our obstetric patient board. The reminder indicated the number of elapsed minutes since placement or last patient assessment. We retrospectively reviewed labor epidural charts 3 months prior to and 5 months following reminder implementation, with a 4-week washout period. The primary outcome was mean time between documented epidural assessments, with secondary outcomes including maximum time between assessments, total number of assessments during labor, catheter replacement rates, and patient satisfaction. Unadjusted comparisons between pre- and postimplementation groups were conducted using Wilcoxon's rank-sum and Pearson's chi-square tests, as appropriate. A test for equal variances was conducted for time between assessment outcomes.
Results Following implementation, mean time between assessments decreased from a median of 173 (interquartile range [IQR]: 53, 314) to 100 (IQR: 74, 125) minutes (p <0.001), and maximum time between assessments decreased from median 330 (IQR: 60, 542) to 162 (IQR: 125, 212) minutes (p < 0.001). Total number of evaluations during labor increased from 3 (IQR: 2, 4) to 5 (IQR: 3, 7; p < 0.001). Decreased variance in mean and maximum time between assessments was noted following reminder implementation (p < 0.001). Epidural replacement rates decreased from 14 to 5% postimplementation (p < 0.001). Patient satisfaction was unchanged.
Conclusion Implementation of an informatics-based solution can promote standardization of care. A simple epidural rounding reminder prompted clinicians to perform more frequent labor epidural assessments. In the future, these process improvements must be linked to improvements in patient experiences and outcomes.
Ten Years of Medical Informatics and Standards Support for Clinical Research in an Infectious Diseases Network
Authors: Mora Sara , Giannini Barbara , Di Biagio Antonio , Cenderello Giovanni , Nicolini Laura Ambra , Taramasso Lucia , Dentone Chiara , Bassetti Matteo , Giacomini Mauro 
Published: January 2023

Abstract
Background It is 30 years since evidence-based medicine became a great support for individual clinical expertise in daily practice and scientific research. Electronic systems can be used to achieve the goal of collecting data from heterogeneous datasets and to support multicenter clinical trials. The Ligurian Infectious Diseases Network (LIDN) is a web-based platform for data collection and reuse originating from a regional effort and involving many professionals from different fields.
Objectives The objective of this work is to present an integrated system of ad hoc interfaces and tools that we use to perform pseudonymous clinical data collection, both manually and automatically, to support clinical trials.
Methods The project comprehends different scenarios of data collection systems, according to the degree of information technology of the involved centers. To be compliant with national regulations, the last developed connection is based on the standard Clinical Document Architecture Release 2 by Health Level 7 guidelines, interoperability is supported by the involvement of a terminology service.
Results Since 2011, the LIDN platform has involved more than 8,000 patients from eight different hospitals, treated or under treatment for at least one infectious disease among human immunodeficiency virus (HIV), hepatitis C virus, severe acute respiratory syndrome coronavirus 2, and tuberculosis. Since 2013, systems for the automatic transfer of laboratory data have been updating patients' information for three centers, daily. Direct communication was set up between the LIDN architecture and three of the main national cohorts of HIV-infected patients.
Conclusion The LIDN was originally developed to support clinicians involved in the project in the management of data from HIV-infected patients through a web-based tool that could be easily used in primary-care units. Then, the developed system grew modularly to respond to the specific needs that arose over a time span of more than 10 years.
Facile layer-by-layer fabrication of semiconductor microdisk laser particles
Authors: Dannenberg Paul H. , Liapis Andreas C. , Martino Nicola , Sarkar Debarghya , Kim Kwon-Hyeon , Yun Seok-Hyun 
Published: January 2023

Semiconductor-based laser particles (LPs) with an exceptionally narrowband spectral emission have been used in biological systems for cell tagging purposes. The fabrication of these LPs typically requires highly specialized lithography and etching equipment and is typically done in a cleanroom environment, hindering the broad adoption of this exciting new technology. Here, using only easily accessible laboratory equipment, we demonstrate a simple layer-by-layer fabrication strategy that overcomes this obstacle. We start from an indium phosphide substrate with multiple epitaxial indium gallium arsenide phosphide layers that are sequentially processed to yield LPs of various compositions and spectral properties. The LPs isolated from each layer are characterized, exhibiting excellent optical properties with a lasing emission full width at half maximum as narrow as &lt;0.3 nm and typical thresholds of ∼6 pJ upon excitation using a 3 ns pulse duration 1064 nm pump laser. The high quality of these particles renders them suitable for large-scale biological experiments, including those requiring spectral multiplexing.
EURAMET.EM-S44 comparison for ultra-low DC current sources
Authors: Turhan Enis , Erkan Ömer , Hayirli Cem , Istrate Daniela , Németh Tibor , Power Oliver , Ribeiro Luis , Bergsten Tobias , Corminboeuf David 
Published: January 2023

Main text
Comparison for ultra-low DC current sources between LNE (France), BFKH (Hungary), NSAI NML (Ireland), IPQ (Portugal), RISE (Sweden), METAS (Switzerland) and TÜBİTAK UME (Turkey).
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Update of the BIPM comparison BIPM.RI(II)-K1.Cs-134 of activity measurements of the radionuclide 134Cs to include the 2014 result of the POLATOM (Poland), the 2014 result of the NRC (Canada), the 2015 result of the LNMRI-IRD (Brazil) and the 2016 result of the PTB (Germany)
Authors: Michotte C , Courte S , Coulon R , Nonis M , Judge S , Ratel G , Silva C J da , Galea R , Moore K , Dziel T , Muklanowicz A , Marganiec-Gałązka J , Nähle O , Kossert K 
Published: January 2023

Main text
Since 1976, 23 laboratories have submitted 44 samples of 134Cs to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Cs-134. In the last few years, the POLATOM (Poland), the NRC (Canada), the LNMRI-IRD (Brazil) and the PTB (Germany) participated in the comparison and the key comparison reference value (KCRV) has been updated. The degrees of equivalence between each equivalent activity measured in the SIR or linked to the SIR from the APMP.RI(II)-K2.Cs-134 comparison and the updated KCRV have been calculated and the results are given in the form of a table. A graphical representation is also given.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Studying δ-MnO2/reduced graphene oxide composite cathode in a low-temperature and high-voltage-tolerant hybrid electrolyte for aqueous Mg-ion batteries
Authors: Tsai Yi-Ru , Chen Ting-Yu , Yang Zhong-Qi , Tsai Cheng-Che , Huang Yu-Ting , Anuratha Krishnan Shanmugam , Lin Tsung-Wu , Sofer Zdenek , Lin Jeng-Yu 
Published: January 2023

Abstract
Optimization of the aqueous electrolyte concentration is a significant issue in the development of high-performance aqueous rechargeable magnesium ion batteries (MIBs). In this study, a novel magnesium ion-based hybrid electrolyte composed of 2 M magnesium sulfate (MgSO4)/2 M acetate (MgOAc) was designed, and its corresponding physiochemical properties were systemically investigated by simply tuning their molar ratios. Additionally, a δ-MnO2/reduced graphene oxide (rGO) composite cathode material was successfully synthesized and delivered a high specific capacity and excellent rate capability in the optimized hybrid electrolyte. The as-fabricated device based on the δ-MnO2/rGO composite cathode exhibited a high operating voltage of up to 2 V and delivered a maximum energy density of 29.8 Wh kg−1 at the power density of 823 W kg−1. More importantly, the device showed impressive discharge capacity and excellent cycling stability even at the low temperature of −20 °C. In view of the outstanding electrochemical properties of the δ-MnO2/rGO composite cathode in an optimized hybrid electrolyte of MgSO4/MgOAc, it could be regarded as a novel prototype for low-cost aqueous MIBs.
Hitting probabilities of Gaussian random fields and collision of eigenvalues of random matrices
Authors: Lee Cheuk , Song Jian , Xiao Yimin , Yuan Wangjun 
Published: January 2023

Let

X
=
{
X
(
t
)
,
t
∈

R

N

}

X= \{X(t), t \in \mathbb {R}^N\}

be a centered Gaussian random field with values in

R

d

\mathbb {R}^d

satisfying certain conditions and let

F
⊂

R

d

F \subset \mathbb {R}^d

be a Borel set. In our main theorem, we provide a sufficient condition for

F
F

to be polar for

X
X

, i.e.

P

(

X
(
t
)
∈
F
for some
t
∈

R

N

)

=
0

\mathbb P\big ( X(t) \in F \text { for some } t \in \mathbb {R}^N\big ) = 0

, which improves significantly the main result in Dalang et al. [Ann. Probab. 45 (2017), pp. 4700–4751], where the case of

F
F

being a singleton was considered. We provide a variety of examples of Gaussian random field for which our result is applicable. Moreover, by using our main theorem, we solve a problem on the existence of collisions of the eigenvalues of random matrices with Gaussian random field entries that was left open in Jaramillo and Nualart [Random Matrices Theory Appl. 9 (2020), p. 26] and Song et al. [J. Math. Anal. Appl. 502 (2021), p. 22].
AFP-MFL: accurate identification of antifungal peptides using multi-view feature learning
Authors: Fang Yitian , Xu Fan , Wei Lesong , Jiang Yi , Chen Jie , Wei Leyi , Wei Dong-Qing 
Published: January 2023

Abstract
Recently, peptide-based drugs have gained unprecedented interest in discovering and developing antifungal drugs due to their high efficacy, broad-spectrum activity, low toxicity and few side effects. However, it is time-consuming and expensive to identify antifungal peptides (AFPs) experimentally. Therefore, computational methods for accurately predicting AFPs are highly required. In this work, we develop AFP-MFL, a novel deep learning model that predicts AFPs only relying on peptide sequences without using any structural information. AFP-MFL first constructs comprehensive feature profiles of AFPs, including contextual semantic information derived from a pre-trained protein language model, evolutionary information, and physicochemical properties. Subsequently, the co-attention mechanism is utilized to integrate contextual semantic information with evolutionary information and physicochemical properties separately. Extensive experiments show that AFP-MFL outperforms state-of-the-art models on four independent test datasets. Furthermore, the SHAP method is employed to explore each feature contribution to the AFPs prediction. Finally, a user-friendly web server of the proposed AFP-MFL is developed and freely accessible at http://inner.wei-group.net/AFPMFL/, which can be considered as a powerful tool for the rapid screening and identification of novel AFPs.
A novel strategy for designing the magic shotguns for distantly related target pairs
Authors: Luo Yongchao , Wang Panpan , Mou Minjie , Zheng Hanqi , Hong Jiajun , Tao Lin , Zhu Feng 
Published: January 2023

Abstract
Due to its promising capacity in improving drug efficacy, polypharmacology has emerged to be a new theme in the drug discovery of complex disease. In the process of novel multi-target drugs (MTDs) discovery, in silico strategies come to be quite essential for the advantage of high throughput and low cost. However, current researchers mostly aim at typical closely related target pairs. Because of the intricate pathogenesis networks of complex diseases, many distantly related targets are found to play crucial role in synergistic treatment. Therefore, an innovational method to develop drugs which could simultaneously target distantly related target pairs is of utmost importance. At the same time, reducing the false discovery rate in the design of MTDs remains to be the daunting technological difficulty. In this research, effective small molecule clustering in the positive dataset, together with a putative negative dataset generation strategy, was adopted in the process of model constructions. Through comprehensive assessment on 10 target pairs with hierarchical similarity-levels, the proposed strategy turned out to reduce the false discovery rate successfully. Constructed model types with much smaller numbers of inhibitor molecules gained considerable yields and showed better false-hit controllability than before. To further evaluate the generalization ability, an in-depth assessment of high-throughput virtual screening on ChEMBL database was conducted. As a result, this novel strategy could hierarchically improve the enrichment factors for each target pair (especially for those distantly related/unrelated target pairs), corresponding to target pair similarity-levels.