bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kontribusi Investasi dan Perdagangan Luar Negeri Terhadap Pertumbuhan Ekonomi
Authors: Teuku Teuku Fahmi 
Published: February 2023

Eksistensi investasi dan perdagangan luar negeri masih menjadi harapan bagi pertumbuhan ekonomi Indonesia. Penelitian ini bertujuan menganalisis pengaruh investasi, ekpor-impor barang dan jasa terhadap pertumbuhan ekonomi (PDB). Penelitian ini menggunakan model analisis data time seriesperiode 1971-2020 yang bersumber dari World Bank dengan model regresi linier berganda pendekatan estimasi parameter Ordinary Least Square (OLS) dengan transfromasi estimasi P(rho) melalui metode Cochrane-Orcutt. Berdasarkan hasil estimasi yang telah dilakukan menunjukkan secara simultan bahwa variabel-variabel independen (bebas) seperti Ekspor -Impor, dan Investasi berpengaruh terhadap pertumbuhan ekonomi. Namun, secara parsial hanya variabel investasi dan impor yang berpengaruh signifikan terhadap pertumbuhan ekonomi sesuai dengan tren kedua variabel tersebut yang meningkat, sedangkan ekspor tidak menunjukkan hubungan signifikan yang disebabkan penurunan kinerja pasca krisis ekonomi yang melanda Indonesia di beberapa periode sebelumnya.Oleh karena itu pemerintah harus tetap konsisten dalam merumuskan kebijakan menjaga kondusifitas iklim investasi dan kebijakan promosi ekspor dan substitusi imporuntuk meningkatkan kinerja perekonomian.
Formulation and in-vitro Evaluation of Ethosomes using Anastrozole as a Modeling Drug
Authors: Neven Nasef AlEbadi  , Mohammed Sabar Al-Lami  
Published: February 2023

Anastrozole (ANZ) is a potent non-steroidal aromatase II inhibitor (AI) used to decrease or delay the progression of breast tumor growth in some women. Since ANZ could be delivered transdermally due to its physicochemical characteristics as (log p of 3.5, aqueous solubility of 0.5 mg /mL, low dosage and half-life of 46.8 hr.) so, it could be used as a modelling drug evaluation of ethosomes, the current study aimed to formulate ANZ loaded ethosomes and evaluate the formulated ethosomes for particle size and PDI, entrapment efficiency and in vitro release profile. Film hydration method was used to prepare ANZ-loaded ethosoms. using different ratios of phospholipid (Soy phosphatidyl choline) and ethanol at variables probe sonication energy and time ratios.
polydispersity index and particle size were used to evaluate the prepared ANZ-loaded ethosoms. The optimized formula of ethosomes which contain (1% Soy phosphatidyl choline,20% ethanol subjected to 300watt sonication energy with 1/3 sonication on /off ratio) was studied for in vitro drug release. It had 127.75±0.36 nm particle diameter and 74.7136 ± 3.457 % entrapment efficiency, the release kinetics obey Korsmeyer-Peppas and non-Fickian release as R2=0.9779 and n=0.737.
The ratios of Soy phosphatidyl choline, ethanol, sonication energy and duration had a significant impact on the particle size of ethosomes at (p0.05). The preformulating analysis of Powder X-ray diffraction (P-XRD) indicate amorphous ethosomes. Fourier transform infrared (FTIR) showed the inertness among components.
PREVENTION OF PREVIOUS OPERATION OF CHARGES OF PYROTECHNICAL PRODUCTS BASED ON MIXTURES OF MAGNESIUM, ALUMINUM POWDER AND METAL WASTE IN THE CONDITIONS OF EXTERNAL THERMAL ACTIONS
Authors: Kyrychenko Ievgen , Hvozd Viktor , Kyrychenko Oksana , Diadiushenko Oleksandr 
Published: February 2023

Mathematical models of external heating of charges of pyrotechnic products based on compacted mixtures of aluminum-magnesium alloy powders and nitrate-containing oxidizers (sodium, potassium, strontium, and barium nitrates) were refined by taking into account the temperature dependence of their thermophysical properties (volumetric heat capacity and coefficient of thermal conductivity), which allowed to more accurately determine the critical values of heat flows and durations of their influence.
New data were obtained to determine the critical ranges of the change in the burning rate of mixtures under conditions of elevated heating temperatures and external pressures for various values of technological parameters (the coefficient of excess oxidizer α; the average particle size of metal fuel powders dм microns and oxidizer dN), exceeding the ranges of which leads to premature ignition mixtures under conditions of external thermal effects and leads to unstable explosive development of their combustion process and fire-hazardous destruction of pyrotechnic products.
The impact of automated control of indoor air pollutants on cardiopulmonary health, environmental comfort, sleep quality in a simulated apartment: A crossover experiment protocol
Authors: Pantelic Jovan , Aristizabal Sara , Liu Qingyang , Senerat Araliya , Son Young Joo , Byun Kunjoon , Li Linhao , Mullan Aidan , Zhang Rongpeng , Johnson Bruce D. , Clements Nicholas 
Published: February 2023

Air pollution makes an impact on cardio-pulmonary health. Since people spend over 90% of their time indoors, exposures to the indoor environment make the most significant impact on health. Among indoor sources, cooking emits the most particles that disperse through the residential indoor environment and expose occupants. We use fully controlled simulated residential modules to conduct exposure experiments. In the pilot study, participants stayed in modules for 1 week, and in the main study, 14 participants will stay in the module for 4 weeks. One module is operated as a classical US house air supply recommendation. The second module has an advanced control system that, alongside the standard air supply, activates air quality interventions: stove hood, portable air cleaners, bathroom exhaust and air flush (increasing air supply ∼3 times) as a function of the PM2.5 levels in the space. Environmental sensors based on Internet of Things technology simultaneously monitored Particulate Matter (PM2.5), CO2, Total Volatile Organic Compounds Relative Humidity and air temperature in all spaces and operated air quality interventions. Participant’s scheduled activities include morning and evening tasks, Monday through Friday. Participants may leave the module during the day. They will be asked to cook breakfast and dinner using lab-provided recipes. We measured each participant’s blood pressure, heart rate, and heart rate variability. Blood and urine samples were collected 3 times per participant in the pilot and will be collected 2 times a week in the main study. Up to 20 ml of blood and a minimum of 30 ml of urine will be sampled per collection. Analysis of blood and urine was performed for 8-hydroxy-2-deoxyguanosine (8-OHdG, urine), von Willebrand Factor (vWF, blood plasma), high sensitivity C-Reactive Protein (hsCRP, blood serum), Interleukin-6 (blood plasma), CD11b (blood), Fibrinogen (blood plasma), and Myeloperoxidase (blood serum). We conducted a Pilot for 2 weeks with 3 participants to test the study protocol and data collection. We adjusted the protocol for the main study based on the pilot results. Results showed that the proposed study protocol could be completed, and the methodology adopted in this study will provide valuable insights into the relationship between exposure to cooking particles and occupants' health.Trial registration: Mayo Clinic IRB 20-007908.
Coating of chitosan on poly D,L-lactic-co-glycolic acid thymoquinone nanoparticles enhances the anti-tumor activity in triple-negative breast cancer
Authors: Gao Jingrong , Kumari Ankita , Zeng Xin-An , Chan Siewyin , Farooq Muhammad Adil , Alee Mahafooj , Khan Shaheer Hasan , Rahaman Abdul , He Shan , Xin Xiong , Mehmood Tariq 
Published: February 2023

Breast cancer is the second most common cancer around the world. Triple-negative breast cancer (TNBC) is characterized by the absence of three receptors: progesterone, estrogen, and human epidermal growth factor-2 receptor (HER2). Various synthetic chemotherapies have gained attention but they caused unwanted side effects. Therefore, some secondary therapies are now becoming famous against this disease. For instance, natural compounds have been extensively researched against many diseases. However, enzymatic degradation and low solubility remain a major concern. To combat these issues, various nanoparticles have been synthesized and optimized from time to time, which increases its solubility and hence therapeutic potential of a particular drug increases. In this study, we have synthesized Poly D,L-lactic-co-glycolic acid (PLGA) loaded thymoquinone (TQ) nanoparticle (PLGA-TQ-NPs) and then coated them by chitosan (CS) (PLGA-CS-TQ-NPs), which was characterized by different methods. Size of non-coated NPs was 105 nm with PDI value of 0.3 and the size of coated NPs was 125 nm with PDI value of 0.4. Encapsulation efficiency (EE%) and Drug loading (DL%) was found to be 70.5 ± 2.33 and 3.38 for non-coated and 82.3 ± 3.11 and 2.66 for coated NPs respectively. We have also analysed their cell viability against MDA-MB-231 and SUM-149 TNBC cell lines. The resultant, nanoformulations exhibit anti-cancerous activity in a dose and time-dependent manner for MDA-MB-231 and SUM-149 cell lines with an IC50 value of (10.31 ± 1.15, 15.60 ± 1.25, 28.01 ± 1.24) and (23.54 ± 1.24, 22.37 ± 1.25, 35 ± 1.27) for TQ free, PLGA-TQ-NPs and PLGA-CS-TQ-NPs respectively. For the first time, we have developed a nanoformulations of PLGA loaded TQ coated with CS NPs (PLGA-CS-TQ-NPs) against TNBC which led to their enhanced anti-cancerous effects.
Genetic and phenotypic assessment of the antimicrobial activity of three potential probiotic lactobacilli against human enteropathogenic bacteria
Authors: Kiousi Despoina Eugenia , Efstathiou Christos , Tzampazlis Vasilis , Plessas Stavros , Panopoulou Maria , Koffa Maria , Galanis Alex 
Published: February 2023

IntroductionLactobacilli are avid producers of antimicrobial compounds responsible for their adaptation and survival in microbe-rich matrices. The bactericidal or bacteriostatic ability of lactic acid bacteria (LAB) can be exploited for the identification of novel antimicrobial compounds to be incorporated in functional foodstuffs or pharmaceutical supplements. In this study, the antimicrobial and antibiofilm properties of Lactiplantibacillus pentosus L33, Lactiplantibacillus plantarum L125 and Lacticaseibacillus paracasei SP5, previously isolated form fermented products, were examined, against clinical isolates of Staphylococcus aureus, Salmonella enterica subsp. enterica serovar Enteritidis and Escherichia coli.MethodsThe ability of viable cells to inhibit pathogen colonization on HT-29 cell monolayers, as well as their co-aggregation capacity, were examined utilizing the competitive exclusion assay. The antimicrobial activity of cell-free culture supernatants (CFCS) was determined against planktonic cells and biofilms, using microbiological assays, confocal microscopy, and gene expression analysis of biofilm formation-related genes. Furthermore, in vitro analysis was supplemented with in silico prediction of bacteriocin clusters and of other loci involved in antimicrobial activity.ResultsThe three lactobacilli were able to limit the viability of planktonic cells of S. aureus and E. coli in suspension. Greater inhibition of biofilm formation was recorded after co-incubation of S. enterica with the CFCS of Lc. paracasei SP5. Predictions based on sequence revealed the ability of strains to produce single or two-peptide Class II bacteriocins, presenting sequence and structural conservation with functional bacteriocins.DiscussionThe efficiency of the potentially probiotic bacteria to elicit antimicrobial effects presented a strain- and pathogen-specific pattern. Future studies, utilizing multi-omic approaches, will focus on the structural and functional characterization of molecules involved in the recorded phenotypes.
Detection of former goaf and analysis of deformation characteristics of overburden in Dameidong coal mine
Authors: Wei Zhan-Xi , Zhao Meng , Xie Fei-Hong , Cao Sheng-Hong , Dong Jian-Hui , Dong Yang-Dan 
Published: February 2023

In order to analyze the deformation of the old goaf in Dameidong Coal Mine and its influence on the surrounding rock and soil layer, it provides guidance for the prevention and control of geological disasters in the region. In this paper, the transient electromagnetic method and numerical simulation method were used to study the deformation law of the overlying strata in the mining area. The results of transient electromagnetic detection showed that the subsidence area of the goaf in Dameidong Coal Mine was within the range of the elliptical water-rich area, and the average buried depth of the goaf was expected to be 90 m. The model was established by discrete element numerical simulation to study the variation law of mining overburden rock. The results showed that the stress change in coal mining was mainly reflected at both ends of the goaf, which was a stress concentration phenomenon. Overburden rock deformation changed with the mining process. The stress concentration area and the displacement change area were highly coincident, consisted with the displacement monitoring map, showing a “U”-type distribution. The results proved that the numerical simulation results do have theoretical guidance for mining subsidence control.
A Single-Point Insulin Sensitivity Estimator (SPISE) of 5.4 is a good predictor of both metabolic syndrome and insulin resistance in adolescents with obesity
Authors: Correa-Burrows Paulina , Matamoros Mariela , de Toro Valeria , Zepeda Diego , Arriaza Marta , Burrows Raquel 
Published: February 2023

BackgroundThe Single-Point Insulin Sensitivity Estimator (SPISE) is a biomarker of insulin sensitivity estimated using BMI and triglycerides and high-density lipoprotein cholesterol. We assessed the accuracy of SPISE to screen obesity-related cardiometabolic risk in children and adolescents.MethodCross-sectional validation study for a screening test in a sample of n=725 children and adolescents from an obesity clinic. Weight, height, waist circumference, blood arterial pressure, lipid profile, glucose, insulin and Tanner stage were measured. BMI, BMI for-age-and sex (BAZ), and HOMA-IR were estimated. HOMA-IR values ≥2.1 and ≥3.3 were considered IR in Tanner I-II, ≥3.3 for Tanner III-IV and ≥2.6 for Tanner V, respectively. Metabolic Syndrome (MetS) was diagnosed with the Cook phenotype. SPISE was estimated according to the following algorithm: [600* HDL^0.185/(TG^0.2* BMI^1.338)]. The optimal SPISE cut points for IR and MetS prediction were determined by ROC curve analysis.ResultsIn prepubertal obese patients (9.2 ± 2.1y; 18.4% males), the prevalence of IR and MetS was 28.2% y 46.9%, respectively; 58% had severe obesity (BAZ ≥4 SD). In pubertal obese patients (12.6 ± 1.8y; 57% males), the prevalence of IR and MetS was 34.1% and 55.3%, respectively; 34% had severe obesity. In prepubertal children, a SPISE of 6.3 showed the highest sensitivity (73.2%) and specificity (80%) to screen individuals with IR (AUC: 0.80; LR +: 3.3). Likewise, a SPISE of 5.7 got the highest sensitivity (82.6%) and specificity (86.1%) to screen patients with MetS (AUC: 0.87; LR +: 5.4). In pubertal patients, a SPISE of 5.4 showed the highest sensitivity and specificity to screen children and adolescents with both IR (Sn: 76.1%; Sp: 77.5%; AUC: 0.8; LR +: 3.1) and MetS (Sn: 90.4%; Sp: 76.1%; AUC: 0.90; LR +: 3.5).ConclusionIn children and adolescents with obesity, SPISE has good or very good performance in predicting IR and MetS. SPISE may be considered a relatively simple and low-cost diagnosis tool that can be helpful to identify patients with greater biological risk. In adolescents with obesity, the same cut point allows identification of those at higher risk of both IR and MetS.
Adsorption of hexavalent chromium from water using graphene oxide/zinc molybdate nanocomposite: Study of kinetics and adsorption isotherms
Authors: K. S. Merija , Rahulan K. Mani , Sujatha R. Annie , Little Flower N. Angeline 
Published: February 2023

Hexavalent chromium is one of the most hazardous contaminants that threaten the environment. The present research work involves the synthesis of Graphene Oxide/Zinc molybdate (GO/ZM) nanocomposite by wet chemical route. The structure and morphology of the synthesized samples were analysed by various characterization techniques such as X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis Spectroscopy, and High-Resolution Transmission Electron Microscopy (HR-TEM), Brunauer-Emmett-Teller (BET) surface area analysis, Barrett-Joyner-Halenda (BJH) pore size analysis and Raman Spectroscopy. The efficiency of the prepared samples for removing hexavalent chromium from the water was investigated by performing batch adsorption studies. The maximum adsorption capacity was optimum at using 6 mg adsorbent, under conditions pH 2 with contact time for 120 min and temperature 283 K. Two isotherm models and two kinetic models were used to study the adsorption mechanism of Cr(VI) ions adsorption on the surface of GO/ZM nanocomposite. The results of isotherm and kinetic modelling shows that the adsorption of Cr(VI) using GO/ZM nanocomposite was well described by Freundlich Isotherm model with higher correlation coefficient (R2 = .985) and follows pseudo second order kinetic model.
Knowledge mining for the differentiation pattern with respect to the productivity and trophic status of some selected lakes of Western Himalayas
Authors: Kumar Rakesh , Jindal Rajinder , Kulharia Mahesh , Sharma Amit Kumar , Thakur Kushal , Brar Bhavna , Mahajan Danish , Sharma Ankita , Kumar Sunil , Sharma Dixit 
Published: February 2023

The present study deals with an account of the primary productivity and trophic status of Rewalsar, Kuntbhyog, and Prashar lakes of Western Himalayas. Seasonal variations in gross primary productivity (GPP) (g C m–2 day–1), net primary productivity (NPP, respiration (R), and the NPP/R ratio have been studied and compared with hydrobiological factors. Among various factors, temperature, light, nutrients, and chlorophyll a were accountable for high productivity. Nygaard’s trophic state indices were calculated. GPP showed a positive relationship with water temperature, penetration of light, nitrate, and with phosphate. The extensive range of the compound index observed in Rewalsar (12.00–20.00) and Kuntbhyog lakes (12.50–18.00) confirmed their eutrophic nature. Based on the trophic classification of waters and on the basis of productivity, Nygaard’s trophic state indices, and richness of nutrients, Rewalsar and Kuntbhyog lakes could be categorized as eutrophic, whereas Prashar Lake, as oligo-eutrophic. Based on the presence, absence, frequency of appearance, and abundance of different organisms recorded during the present investigation, bioindicators of trophic status have been determined.
High SARS-CoV-2 Infection Rates Among Special Forces Police Units During the Early Phase of the COVID-19 Pandemic in Ecuador
Authors: Ortiz-Prado Esteban , Andrade Felipe , Vasconez Eduardo , Escobar-Espinosa Cristina , Vallejo-Janeta Alexander Paolo , Freire-Paspuel Byron , Coronel Barbara , Galvis Heberson , Morales-Jadan Diana , Rivera-Olivero Ismar A. , Lozada Tannya , Henriquez-Trujillo Aquiles R. , Garcia-Bereguiain Miguel Angel ,   the UDLA-COVID-19 Team
Published: February 2023

BackgroundAt the beginning of the COVID-19 pandemic, health workers and first-responders, such as police officers, were in charge of trying to contain a disease that was unknown at that time. The lack of information and the tremendous need to contain new outbreaks put police officers at higher risk.MethodologyA cross-sectional study was conducted to describe SARS-CoV-2 infection rates among Police Special Forces Officers in Quito, Ecuador. In this study, 163 community-dwelling police officers from elite divisions voluntarily participated in our SARS-CoV-2 detection program using reverse transcription quantitative real-time PCR (RT-qPCR).ResultsA total of 20 out of 163 police officers tested positive for SARS-CoV-2, yielding an infection rate of 12.3%. Within this cohort, 10% (2/20) of SARS-CoV-2 positive individuals were potentially super spreaders with viral loads over 108 copies/ul. About 85% of the SARS-CoV-2 positive individuals were asymptomatic and 15% reported mild symptoms related to COVID-19.ConclusionsWe found a high SARS-CoV-2 infection rate within the special forces police officers that, beyond a high health risk for themselves, their families, and coworkers. Our results point out the need for permanent SARS-CoV-2 testing among asymptomatic essential workers and first-responders to avoid local outbreaks and to prevent work-place absenteeism among police special units.
Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism
Authors: Zhao Shuai , Du Yishan , Zhang Yu , Wang Xiaoqin , Xia Yi , Sun Hao , Huang Yinghong , Zou Haowen , Wang Xumiao , Chen Zhilu , Zhou Hongliang , Yan Rui , Tang Hao , Lu Qing , Yao Zhijian 
Published: February 2023

IntroductionTo explore the association between regional gray matter volume (GMV) and cognitive impairments and ascertain whether the regional brain alterations related to cognitive impairments occur in major depressive disorder (MDD) patients with comorbid subclinical hypothyroidism (SHypo).MethodsWe enrolled 32 MDD patients, 32 MDD patients with comorbid SHypo, and 32 normal controls and subjected them to thyroid function tests, neurocognitive tests, and magnetic resonance imaging (MRI). Using voxel-based morphometry (VBM) analysis, we examined the pattern of gray matter (GM) in these participants. We also used ANOVA to detect group differences and partial correlation to explore the potential association between GMV alterations and cognitive tests in comorbid patients.ResultsThe comorbid patients exhibited significantly smaller GMV in the right middle frontal gyrus (MFG) than the non-comorbid group. Furthermore, the partial correlation analysis showed that GMV of the right MFG was associated with poor executive function (EF) performance in comorbid patients.ConclusionThese findings provide valuable insight into the relationship between the alteration of GMV and cognitive dysfunction of MDD patients with comorbid SHypo.
Neural network aided flexible joint optimization with design of experiment method for nuclear power plant inspection robot
Authors: Wang Gang , Li Jiawei , Ma Xinmeng , Chen Xi , Wang Jixin , Han Songjie , Pan Biye , Tian Ruxiao 
Published: February 2023

IntroductionThe flexible joint is a crucial component for the inspection robot to flexible interaction with nuclear power facilities. This paper proposed a neural network aided flexible joint structure optimization method with the Design of Experiment (DOE) method for the nuclear power plant inspection robot.MethodsWith this method, the joint's dual-spiral flexible coupler was optimized regarding the minimum mean square error of the stiffness. The optimal flexible coupler was demonstrated and tested. The neural network method can be used for the modeling of the parameterized flexible coupler with regard to the geometrical parameters as well as the load on the base of the DOE result.ResultsWith the aid of the neural network model of the stiffness, the dual-spiral flexible coupler structure can be fully optimized to a target stiffness, 450 Nm/rad in this case, and a given error level, 0.3% in the current case, with regard to the different loads. The optimal coupler is fabricated with wire electrical discharge machining (EDM) and tested.DiscussionThe experimental results demonstrate that the load and angular displacement keep a good linear relationship in the given load range and this optimization method can be used as an effective method and tool in the joint design process.