bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fixed‐time sliding mode observer‐based controller for a class of uncertain nonlinear double integrator systems
Authors: Alinaghi Hosseinabadi Pooyan , Soltani Sharif Abadi Ali , Schwartz Howard , Pota Hemanshu , Mekhilef Saad 
Published: March 2023

AbstractThis paper investigates a fixed‐time convergence issue using the sliding mode observer‐based controller for a class of uncertain nonlinear double integrator systems. This observer‐based controller is designed assuming that only the first state measurement is available and there is no information about external disturbances and modeling uncertainties. A new form of sliding mode observer in combination with a sliding mode controller is designed to estimate unmeasured state and unknown disturbances and uncertainties as well as provide the estimated data in the control law. A novel form of sliding surfaces for the robust observer‐based controller is proposed for which fixed‐time convergence is guaranteed to achieve trajectory tracking. In the proposed fixed‐time scheme, the bound on the settling time is user‐defined using design parameters regardless of the system's initial conditions. The control law and observer law are designed such that the chattering issue is alleviated in the control signal. The stability analysis of the closed‐loop system using the observer‐based controller is established via the Lyapunov theory. The validity of the controller design is tested by applying and simulating an example of a robot manipulator in Simulink/MATLAB. The superiority of the proposed method is demonstrated by comparing it with two other methods from the relevant literature.
Variability in North Sea wind energy and the potential for prolonged winter wind drought
Authors: Kay Gillian , Dunstone Nick J. , Maidens Anna , Scaife Adam A. , Smith Doug M. , Thornton Hazel E. , Dawkins Laura , Belcher Stephen E. 
Published: March 2023

AbstractThe United Kingdom is committed to substantially increasing offshore wind capacity in its drive to decarbonise electricity production and achieve net zero. If low wind episodes—or ‘wind drought’ events—occur during high energy demand periods, energy security may be threatened without alternative supply. The challenge of managing the variability of wind power will increase into the future as its share in the energy mix increases. This study focuses attention on the North Sea as a centre of current and planned offshore wind resource, and on the winter season, given the occurrence of weather patterns that risk security of supply. We use a large climate model ensemble, providing a dataset an order of magnitude larger than the reanalysis‐based observations, to better sample wind drought events. This leads to a more robust estimate of their frequency and persistence and their dynamical teleconnections compared with the observational record. We define week‐long wind drought events, based on a 20th percentile threshold in 10 m wind speed, during which wind power is estimated to be around half that in a typical week of winter. Wind drought events of up to two consecutive weeks have been observed, but the model indicates a 1‐in‐40 chance of three or more continuous weeks of wind drought each winter, with the single most prolonged simulated event lasting 5 weeks. There is a doubling of the likelihood of these prolonged wind drought events during El Niño, indicating that monitoring and predicting the state of the tropical Pacific may be useful in assessing the risk of wind drought events in an upcoming winter.
A validated ecofriendly chromatographic method for determination of myasthenia gravis combined medications in spiked human plasma
Authors: Magdy Maimana A. , Farid Nehal F. , Anwar Basma H. , Abdelhamid Nessreen S. 
Published: March 2023

AbstractRecently, the main interest of analytical chemistry researchers has been the development of green analytical methods to minimize harmful effects on the environment and natural life. Therefore, an RP‐HPLC method was developed and assessed regarding its greenness criteria using three greenness assessment tools: an analytical eco‐scale, an analytical greenness metric approach and a green analytical procedure index. This method aims to separate and quantitatively determine three co‐administered drugs, namely pyridostigmine bromide (PYR), 6‐mercaptopurine (MRC) and prednisolone (PRD), in their tertiary mixture and spiked human plasma. These drugs are co‐administered to manage myasthenia gravis autoimmune disease. The separation was done using a C18 column and a gradient elution of a mixture of 0.1% H3PO4 aqueous solution (pH 2.3) and methanol. The flow rate was adjusted to 1 ml/min and detection was done at 254 (for PYR and PRD) and at 330 nm (for MRC). The lower limits of quantitation were 15, 2, and 5 μg/ml for PYR, MER and PRD, respectively. Linear correlations were obtained and found to be near 1. In addition, the proposed method was validated according to the US Food and Drug Administration's instructions, and the results proved its success to determine the three studied drugs in their tertiary mixture and spiked human plasma.
Strategic engagement of business with Sustainable Development Goals: A systems thinking approach
Authors: Erzurumlu S. Sinan , Deets Stephen , Nersessian David , Rodgers Vikki L. 
Published: March 2023

AbstractPrivate companies seeking to heighten their social responsibility and reduce ecological impacts often lack practical approaches to discern high‐impact and cost‐effective changes. Deeper understanding of the interrelated economic, social, and ecological systems reflected in the United Nations Sustainable Development Goals (UN SDGs) can enhance their ability to positively connect and influence both internal and external aspects of the integrated business and socio‐ecological system. Through an inductive study of three companies, this article demonstrates that systems thinking provides a valuable approach to help companies to understand and map the systems in which they operate, enabling them to expand their sustainability practices even as they address profit‐versus‐impact conflicts. We examine how strategic business goals and activities interplay with an organization's socio‐ecological system and thereby enhance business engagement with the SDGs. Our key contribution is a systems‐minded sustainable business framework using three processes: goal–purpose alignment, partnerships, and systemic interplay. We explain each company's sustainability efforts and their relative engagement with the SDGs as well as relative impact of such engagement on the company in return.
Evaluation of cortical bone density using clinical computed tomography images: Detection of cortical porosity areas or transitional zones in human femoral diaphyses
Authors: Hamamoto Ayami , Ogami‐Takamura Keiko , Saiki Kazunobu , Endo Daisuke , Murai Kiyohito , Tsurumoto Toshiyuki 
Published: March 2023

AbstractAge‐related changes in human trabecular bone and cortical bone are known to vary. Although the porosity of cortical bone has been suggested to increase the risk of bone fracture, most of the currently available instruments for osteoporosis testing target trabecular bone. In this study, we evaluated cortical bone density using clinical computed tomography (CT) and compared the reliability of the cortical bone density index (CDI) with that of a polished male femoral bone from the same region. CDI images revealed that the porous area of cortical bone was extended in low CDI values. Moreover, this method was used to semi‐quantitatively evaluate the cortical bones of the diaphysis of male femur specimens (n = 46). We found that there was a significant relationship (r = 0.70, p < 0.01) between the value of the cortical index (the ratio of cortical bone area to the cross‐sectional area of the femoral diaphysis) and the average of CDI in the low signal area. Our findings suggest that the smaller the cortical bone occupancy, the more areas of consequential bone density loss were present. This may be the first step toward using clinical CT to assess cortical bone density.
Exploring the relationship between secondary traumatic stress, professional identity and career factors for counsellors
Authors: Maurya Rakesh K. , DeDiego Amanda C. 
Published: March 2023

AbstractThis study used a correlational research design to explore the relationship between secondary traumatic stress, counsellor professional identity and career factors, including work setting and amount of counselling experience, among counsellor practitioners. A sample of 1,218 counsellors completed an online survey including the Secondary Traumatic Stress Scale (STSS), Professional Identity Scale in Counseling and career factors. Career factors included context of work environments including years of experience, licence status, type of practice and work setting. Multiple regression analysis with forward selection demonstrated that, out of all the variables, professional identity emerged as the best predictor of secondary traumatic stress. One‐way ANOVA showed significant group differences in the level of counsellors' secondary traumatic stress based on work setting, level of experience, type of practice and gender. Discussion explores how career and personal factors impact counsellor experiences of professional identity and secondary trauma in mental health settings.
The relationship between chronic kidney disease and “complex” percutaneous coronary intervention: Uncovering the details
Authors: Postalian Alexander , Krajcer Zvonimir 
Published: March 2023

Key Points
It remains unclear whether the complexity level of coronary interventions affects cardiovascular outcomes in patients with chronic kidney disease (CKD).
This study showed that “complex” percutaneous coronary intervention (PCI) is associated with a greater risk of adverse cardiovascular events than standard PCI in both patients with or without CKD. However, the complexity of PCI appeared to have a greater effect on all‐cause mortality and bleeding in patients with CKD than in those without CKD.
The data presented confirm the predicted effect of CKD on outcomes after complex PCI. However, the similar effect of complex PCI observed in patients with or without CKD suggests that some patients with CKD have an acceptable risk profile to undergo complex intervention. The reported findings should be interpreted with caution; making a patient‐specific decision before PCI is key in this patient population.
Streptococcus Viridans meningitis in an immunocompetent child: A case report
Authors: Goudarzi Ali , Sarmadian Roham , Yousefichaijan Parsa , Gilani Abolfazl 
Published: March 2023

AbstractIn bacterial meningitis, the Viridans streptococci group is not considered a prevalent pathogen. In contrast, the S. viridans group may cause endocarditis and fatal infections in immunocompromised children and adults. We report a 5‐year‐old immunocompetent boy with signs of meningitis. The CSF tested positive for meningitis with streptococcus viridans.
Understanding the Role of Potassium Addition on the Active Centers and Reaction Pathway of MoS2Catalysts for Water Gas Shift Reaction
Authors: Zhao Weitao , Neon Limor Ben , Maugé Françoise , Oliviero Laetitia 
Published: March 2023

AbstractMoS2is a promising sulfur‐resistant candidate for water‐gas shift (WGS) reaction, and its catalytic efficiency can be promoted by alkali metal. In this work, a series of K‐modified MoS2/Al2O3catalysts with variable K/Mo ratios were prepared to elucidate the promotion role of potassium through IR spectroscopy studies. CO adsorption followed by IR spectroscopy shows that after potassium addition the number of accessible edge sites of MoS2slabs is decreased. Meanwhile, the downward shift ofv(CO/MoS2) indicates that the presence of potassium increases the electronic density of Mo atoms. This electronic effect activates terminal S atoms, favoring their reaction with CO to form COS at lower temperature than in absence of K. Additionally, conversely to the case of MoS2/Al2O3catalysts, little or even no formate species are observed on K‐modified MoS2catalysts during IRoperandostudies, implying a change of the WGS reaction route that would explain the beneficial effect of K on MoS2edge site activity.
Electro‐Oxidation of Polyols on Bi‐Modified Pt in Acidic Media (HClO4). Understanding Activity and Selectivity Trends
Authors: Soffiati Gabriela , Yukuhiro Victor Y. , Raju Swathi P. , De Souza Matheus B. C. , Marquezini Leonardo , da Silva Edison Z. , Fernández Pablo S. , San‐Miguel Miguel A. 
Published: March 2023

AbstractHerein we show that Pt(111) and Pt(100) can produce the ketone through the oxidation of the secondary carbon of the polyols. After the Bi modification, the selectivity for the ketone formation increases. On the other hand, we observe that pure and Bi‐modified Pt(110) only produced the C3 molecules oxidized in the primary carbon, and it is the only facet that shows an enhancement in the activity due to the modification. In line with these findings, small Pt nanoparticles are not selective for ketone formation. Finally, based on data obtained through DFT calculations, we suggest that positively charged Bi adatoms interact with the OH‐ groups of the enediol‐like intermediate (believed to be the precursor for the ketone/aldehyde production), facilitating the oxidation of the secondary carbon to produce DHA.
An Amorphous Teflate Doped Aluminium Chlorofluoride: A Solid Lewis‐Superacid for the Dehydrofluorination of Fluoroalkanes
Authors: Bui Minh , Hoffmann Kurt F. , Braun Thomas , Riedel Sebastian , Heinekamp Christian , Scheurell Kerstin , Scholz Gudrun , Stawski Tomasz M. , Emmerling Franziska 
Published: March 2023

AbstractAn anion‐doped aluminium chlorofluoride AlCl0.1F2.8(OTeF5)0.1 (ACF‐teflate) was synthesized. The material contains pentafluoroorthotellurate (teflate) groups, which mimic fluoride ions electronically, but are sterically more demanding. They are embedded into the amorphous structure. The latter was studied by PDF analysis, EXAFS data and MAS NMR spectroscopy. The mesoporous powder is a Lewis superacid, and ATR‐IR spectra of adsorbed CD3CN reveal a blue‐shift of the adsorption band by 73 cm−1, which is larger than the shift for SbF5. Remarkably, ACF‐teflate catalyzes dehydrofluorination reactions of monofluoroalkanes to yield olefins in C6D6. In these cases, no Friedel‐Crafts products were formed.
Synthesis of Unprecedented α/β‐Alternate (1→4)‐Glucans via Stereoselective Iterative Glycosylation
Authors: Yang Fuzhu , Sun Yishan , Xu Peng , Molinaro Antonio , Silipo Alba , Yu Biao 
Published: March 2023

AbstractGlucans are major biomaterials on the earth, with α‐(1→4)‐glucans (i. e., amylose) and β‐(1→4)‐glucans (i. e., cellulose) being the most abundant ones, which are relevant to energy storage and structural function, respectively. Interestingly, (1→4)‐glucans with alternate α/β‐linkages, namely herewith amycellulose, have never been disclosed in nature. Here we report a robust glycosylation protocol for the stereoselective construction of the 1,2‐cis‐α‐ and 1,2‐trans‐β‐glucosidic linkages, which employs an optimal combination of glycosyl N‐phenyltrifluoroacetimidates as donors, TMSNTf2 as promoter, CH2Cl2/nitrile or CH2Cl2/THF as solvents. A broad substrate scope has been demonstrated by coupling five imidate donors with eight glycosyl acceptors, in which most of the glycosylations lead to high yield and exclusively 1,2‐cis‐α‐ or 1,2‐trans‐β‐selectivity. Applying this glycosylation protocol and with an iterative manner, the unprecedented α/β‐alternate (1→4)‐glucans up to a 16‐mer have been synthesized. Differently from amylose, that adopts a compact helicoidal arrangement, the synthetic amycellulose features an extended ribbon‐like conformation, comparable to the extended shape of cellulose.
Antioxidative degradation mechanism of 2‐mercaptobenzimidazole modified TEPA‐MCM‐41 adsorbents for carbon capture from flue gas
Authors: Wang Ruotong , Guo Tuo , Xiang Xiaoju , Yin Yinmei , Guo Qingjie , Wang Yanxia 
Published: March 2023

AbstractSolid amine adsorbents can efficiently adsorb CO2, but a significant problem is that amine groups are oxidized. In this research, tetraethylenepentamine‐impregnated MCM‐41 adsorbents (TEPA‐MCM‐41) were functionally modified with sulphur‐containing antioxidant 2‐mercaptobenzimidazole (described as antioxidant MB) and tns‐(2.4‐di‐tert‐butyl)‐phosphite (defined as antioxidant 168), respectively. The antioxidative degradation mechanism of 8% MB–50% TEPA‐MCM‐41 was analyzed by in situ diffuse reflectance infrared Fourier transform (in situ DRIFT) spectrum and high‐performance liquid chromatography/mass spectrometry (HPLC/mass). The CO2 adsorption capacity of 50% TEPA‐MCM‐41 was 4.30 mmol/g under 15% CO2/85% N2, but decreased to 1.38 mmol/g after oxidation at 100°C for 42 h under 95% N2/5% O2 certain condition. The CO2 capacity of 8% MB–50% TEPA‐MCM‐41 reduced from 3.90 to 2.86 mmol/g. After 30 adsorption cycles under 5% O2/15% CO2/80% N2, the capacity of 8% MB–50% TEPA‐MCM‐41 also only decreased by 16.8%, while 50% TEPA‐MCM‐41 decreased by 63.2%. The reason for the excellent antioxidant stability of 8% MB–50% TEPA‐MCM‐41 is that MB scavenged free radicals from amine oxidation and decomposed the hydroperoxides produced by free radical reactions. The hydroperoxides were decomposed into alcohols (non‐radical products), which were eventually oxidized to sulphonic compounds. The MB modification inhibited the oxidative degradation of solid amine adsorbents guided for the production of antioxidant‐efficient adsorbents.
Ventricular conduction abnormality in patients with mild to moderate cardiomyopathy
Authors: Dhande Mehak , Aronis Konstantinos N. , Thoma Floyd , Mulukutla Suresh , Bhonsale Aditya , Kancharla Krishna , Shalaby Alaa , Voigt Andrew , Mark Estes N. A. , Jain Sandeep K. , Saba Samir 
Published: March 2023

AbstractBackgroundIn mild‐to‐moderate cardiomyopathy, cardiac resynchronization therapy (CRT) is indicated in patients with high burden of right ventricular pacing but not in those with intrinsic ventricular conduction abnormalities.HypothesisWe hypothesized that CRT positively impacts outcomes of patients with intrinsic ventricular conduction delay and left ventricular ejection fraction (LVEF) of 36%‐50%.MethodsOf 18 003 patients with LVEF ≤ 50%, 5966 (33%) patients had mild‐to‐moderate cardiomyopathy, of whom 1741 (29%) have a QRS duration ≥120 ms. Patients were followed to the endpoints of death and heart failure (HF) hospitalization. Outcomes were compared between patients with narrow versus wide QRS.ResultsOf the 1741 patients with mild‐to‐moderate cardiomyopathy and wide QRS duration, only 68 (4%) were implanted with a CRT device. Over a median follow‐up of 3.35 years, 849 (51%) died and 1004 (58%) had a HF hospitalization. The adjusted risk of death (hazard ratio (HR) = 1.11, p = 0.046) and of death or HF hospitalization (HR = 1.10, p = 0.037) were significantly higher in patients with wide versus narrow QRS duration. In patients with wide QRS complex, CRT was associated with reduction in the adjusted risk of death (HR = 0.47, p = 0.020) and of death or HF hospitalization (HR = 0.58, p = 0.008).ConclusionsPatients with mild‐to‐moderate cardiomyopathy and wide QRS duration are rarely implanted with CRT devices and have worse outcomes compared to those with narrow QRS. Randomized trials are needed to examine if CRT has salutary effects in this population.
Chemotherapy with the use of next‐generation tyrosine kinase inhibitors based on measurable residual disease has the potential to avoid hematopoietic stem cell transplantation in treatment for adults with Philadelphia chromosome–positive acute lymphoblastic leukemia
Authors: Xie Mixue , Shi Ting , Jiang Qi , Jia Yunlu , Zhou De , Tong Hongyan , Jin Jie , Zhu Hong‐Hu 
Published: March 2023

AbstractBackgroundAllogeneic hematopoietic stem cell transplantation (allo‐HSCT) as postremission treatment is recommended for Philadelphia‐positive acute lymphoblastic leukemia (Ph+ ALL) in current guidelines. However, comparisons of later generation tyrosine kinase inhibitors (TKIs) plus chemotherapy with allo‐HSCT have yielded similar outcomes. This meta‐analysis was performed to evaluate allo‐HSCT in first complete remission (CR1) versus chemotherapy for adult Ph+ ALL in the TKI era.MethodsPooled assessment of the hematologic and molecular complete response rates was performed after 3‐month TKI treatment. Hazard ratios (HRs) were determined for disease‐free survival (DFS) and overall survival (OS) benefit with allo‐HSCT. The effect of measurable residual disease status on survival benefit was also analyzed.ResultsThirty‐nine retrospective and prospective single‐arm cohort studies involving 5054 patients were included. Combined HRs indicated that in the general population, allo‐HSCT favorably influenced DFS and OS. Achieving complete molecular remission (CMR) within 3 months after starting induction was a favorable survival prognostic factor regardless of whether the patient had undergone allo‐HSCT. Among the patients with CMR, survival rates in the nontransplant subgroup were comparable with those in the transplant subgroup, with the estimated 5‐year OS of 64% versus 58% and 5‐year DFS of 58% versus 51%, respectively. The use of next‐generation TKIs results in a higher proportion of patients achieving CMR (ponatinib 82% vs. imatinib 53%), while improving survival in nontransplant patients.ConclusionOur novel findings suggest that combination chemotherapy plus TKIs leads to a comparable survival benefit as with allo‐HSCT for MRD‐negative (CMR) patients. This study provides novel evidence for allo‐HSCT indications for Ph+ ALL in CR1 in the TKI era.
Association between bariatric surgery and outcomes in chronic myeloid leukemia
Authors: Haddad Fadi G. , Kantarjian Hagop M. , Bidikian Aram , Jabbour Elias J. , Short Nicholas J. , Ning Jing , Xiao Lianchun , Pemmaraju Naveen , DiNardo Courtney D. , Kadia Tapan M. , Marx Kayleigh R. , Garcia‐Manero Guillermo , Ravandi Farhad , Sasaki Koji , Issa Ghayas C. 
Published: March 2023

AbstractBackgroundBariatric surgery is the most effective weight loss intervention. However, it can also decrease the bioavailability of oral medications. Tyrosine kinase inhibitors, the mainstay treatment for chronic myeloid leukemia (CML), are the most successful example of an oral targeted therapy. The impact of bariatric surgery on CML outcomes is unknown.MethodsIn a retrospective analysis, we screened 652 patients with CML and identified 22 with prior bariatric surgery, and compared their outcomes to a matched cohort of 44 patients with no prior bariatric surgery.ResultsThe rate of early molecular response (3‐month BCR::ABL1 < 10% International Scale) was lower in the bariatric surgery group compared with the control group (68% vs. 91%; p = .05), with longer median times to achieve complete cytogenetic (6 vs. 3 months; p = .001) or major molecular responses (12 vs. 6 months; p = .001). Bariatric surgery was associated with inferior event‐free survival (5‐year, 60% vs. 77%; p = .004) and failure‐free survival (5‐year, 32% vs. 63%; p < .0001). In a multivariate analysis, bariatric surgery was the only independent predictor for the risk of treatment failure (hazard ratio, 9.40; 95% CI, 2.71–32.55; p = .0004) or event‐free survival (hazard ratio, 4.24; 95% CI, 1.67–12.23; p = .008).ConclusionsBariatric surgery is associated with suboptimal responses that require adapted treatment strategies.