bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population
Authors: Teiri Hakimeh , Samaei Mohammad Reza , Dehghani Mansooreh , Azhdarpoor Abooalfazl , Mohammadi Farzaneh , Kelishadi Roya , Hajizadeh Yaghoub 
Published: June 2023

AbstractWidespread use of benzophenones (BPs), a group of environmental phenolic compounds, is suspected of interfering with human health. The association of prenatal exposure to benzophenone derivatives with birth outcomes including birth weight and length, head, arm and thoracic circumference, abnormalities, corpulence index and anterior fontanelle diameter (AFD) was investigated. Mother-infant pairs of 166 within PERSIAN cohort population in Isfahan, Iran, in the 1st and 3rd trimesters of pregnancy were assessed. Four common benzophenone metabolites including 2,4-dihydroxy benzophenone (BP-1), 2-hydroxy-4-methoxy benzophenone (BP-3), 4-hydroxy benzophenone (4-OH-BP) and 2,2′-dihydroxy-4-methoxy benzophenone (BP-8) were measured in maternal urine samples. The median concentration of 4-OH-BP, BP-3, BP-1 and BP-8 were 3.15, 16.98, 9.95 and 1.04 µg/g Cr, respectively. In the 1st trimester, 4-OH-BP showed a significant correlation with AFD in total infants, decreasing 0.034 cm AFD per a log unit increase of 4-OH-BP. Within the male neonates, 4-OH-BP in the 1st and BP-8 in the 3rd trimester were significantly associated with head circumference and AFD increase, respectively. Among female neonates in the 3rd trimester, increasing 4-OH-BP and BP-3 concentration was correlated with a decrease in birth weight and AFD, respectively. This study demonstrated that all the target BP derivatives can influence normal fetal growth at any age of the pregnancy, nevertheless, to support these findings further studies are needed in a large and different group population.
Synthesis of new hybrid pyridines catalyzed by Fe3O4@SiO2@urea-riched ligand/Ch-Cl
Authors: Zarei Narges , Zolfigol Mohammad Ali , Torabi Morteza , Yarie Meysam 
Published: June 2023

AbstractHerein, a new heterogeneous catalytic system through modification of urea functionalized magnetic nanoparticles with choline chloride [Fe3O4@SiO2@urea-riched ligand/Ch-Cl] was designed and synthesized. Then, the synthesized Fe3O4@SiO2@urea-riched ligand/Ch-Cl was characterized by using FT-IR spectroscopy, FESEM, TEM, EDS-Mapping, TGA/DTG and VSM techniques. After that, the catalytic usage of Fe3O4@SiO2@urea-riched ligand/Ch-Cl was investigated for the synthesis of hybrid pyridines with sulfonate and/or indole moieties. Delightfully, the outcome was satisfactory and the applied strategy represents several advantages such as short reaction times, convenience of operation and relatively good yields of obtained products. Moreover, the catalytic behavior of several formal homogeneous DESs was investigated for the synthesis of target product. In addition, a cooperative vinylogous anomeric-based oxidation pathway was suggested as rational mechanism for the synthesis of new hybrid pyridines.
A single-center experience of over 300 cases of single-incision robotic cholecystectomy comparing the da Vinci SP with the Si/Xi systems
Authors: Choi Yoo Jin , Sang Nguyen Thanh , Jo Hye-Sung , Kim Dong-Sik , Yu Young-Dong 
Published: June 2023

AbstractMinimally invasive surgery is usually more beneficial than open surgeries in various fields of surgery. With the newly developed Single-Port (SP) robotic surgical system, even single-site surgery has become easier to access. We compared single-incision robotic cholecystectomy between the Si/Xi and SP systems. This retrospective single-center study enrolled patients who underwent single-incision robotic cholecystectomy between July 2014 and July 2021. The clinical outcomes of the da Vinci Si/Xi and SP systems were compared. In total, 334 patients underwent single-incision robotic cholecystectomy (118 Si/Xi vs. 216 SP). The SP group had more chronic or acute cholecystitis than the Si/Xi group did. There was more bile spillage in the Si/Xi group during the surgery. The total operative and docking times were significantly shorter in the SP group. There was no difference in the postoperative outcomes. The SP system is safe and feasible regarding comparable postoperative complication rates and is more convenient regarding docking and techniques.
Flow rate resonance of actively deforming particles
Authors: Parisi Daniel R. , Wiebke Lucas E. , Mandl Judith N. , Textor Johannes 
Published: June 2023

AbstractLymphoid organs are unusual multicellular tissues: they are densely packed, but the lymphocytes trafficking through them are actively moving. We hypothesize that the intriguing ability of lymphocytes to avoid jamming and clogging is in part attributable to the dynamic shape changes that cells undergo when they move. In this work, we test this hypothesis by investigating an idealized system, namely, the flow of self-propelled, oscillating particles passing through a narrow constriction in two dimensions (2D), using numerical simulations. We found that deformation allows particles with these properties to flow through a narrow constriction in conditions when non-deformable particles would not be able to do so. Such a flowing state requires the amplitude and frequency of oscillations to exceed threshold values. Moreover, a resonance leading to the maximum flow rate was found when the oscillation frequency matched the natural frequency of the particle related to its elastic stiffness. To our knowledge, this phenomenon has not been described previously. Our findings could have important implications for understanding and controlling flow in a variety of systems in addition to lymphoid organs, such as granular flows subjected to vibration.
Fuzzy random evaluation of creep model of frozen soft soil in metro tunnel construction using artificial ground freezing technique
Authors: Yao Yafeng , Zhu Yan , Shen Dejian , Zhang Zhemei , Wang Wei 
Published: June 2023

AbstractMastering the creep characteristics of artificial frozen soil and scientifically evaluating the creep model is an important guarantee for the safety of subway tunnel freezing construction. Base on the construction of Nantong metro tunnel, the uniaxial compressive strength tests of the artificially frozen soft soil were carried out to obtain the influence law of temperature on the uniaxial compressive strength, and the uniaxial creep tests were carried out to obtain the influence law of temperature and stress grade on creep, at − 5, − 10 and − 15 °C. The experimental results show that the creep characteristics of frozen soft soil specimens have obvious fuzzy randomness. The traditional ant colony algorithm is improved by optimizing the pheromone fuzzification coefficient, which improves the search efficiency and avoids the local optimum effectively. Subsequently, the improved fuzzy ant colony algorithm is used to invert the flexibility parameters of commonly used permafrost creep models. The fuzzy weight of evaluation index and the fuzzy random evaluation matrix were determined to evaluate the optimal creep model under three different stress levels of frozen soft soil. Finally, the reliability of the fuzzy random evaluation method was verified by engineering measured data.
Generation of pulsatile ERK activity in mouse embryonic stem cells is regulated by Raf activity
Authors: Toyooka Yayoi , Aoki Kazuhiro , Usami Fumiko Matsukawa , Oka Sanae , Kato Azusa , Fujimori Toshihiko 
Published: June 2023

AbstractThe extracellular signal-regulated kinase (ERK) is a serine/threonine kinase that is known to regulate cellular events such as cell proliferation and differentiation. The ERK signaling pathway is activated by fibroblast growth factors, and is considered to be indispensable for the differentiation of primitive endoderm cells, not only in mouse preimplantation embryos, but also in embryonic stem cell (ESC) culture. To monitor ERK activity in living undifferentiated and differentiating ESCs, we established EKAREV-NLS-EB5 ESC lines that stably express EKAREV-NLS, a biosensor based on the principle of fluorescence resonance energy transfer. Using EKAREV-NLS-EB5, we found that ERK activity exhibited pulsatile dynamics. ESCs were classified into two groups: active cells showing high-frequency ERK pulses, and inactive cells demonstrating no detectable ERK pulses during live imaging. Pharmacological inhibition of major components in the ERK signaling pathway revealed that Raf plays an important role in determining the pattern of ERK pulses.
Comparative analysis between operative and non-operative acetabular labral tear injuries in division 1 collegiate athletes
Authors: Hyland Scott S. , Maeso Andres D. , Rogers Mark , Goforth Mike , Brolinson P. Gunnar 
Published: June 2023

AbstractAcetabular labral tears have shown to be difficult to diagnose and manage in an active and competitive athletic population. The goal of this study was to compare NCAA Division 1 collegiate athletes undergoing operative and non-operative management of their labral injuries by assessing ability to return to competition and secondarily evaluate days lost from sport. A retrospective cohort analysis was conducted on Division 1 collegiate athletes from 2005 to 2020, incorporating all varsity university sports. Records showing MRI confirmed diagnosis were included in the cohort, as well as all pertinent clinical data. Data revealed 10/18 (55%) of individuals managed conservatively versus 23/29 (79%) surgically (p-value = 0.0834) were able to return to sport following treatment. Of those athletes, 22 surgical patients experienced a mean of 324 days ± 223 days lost from sport and nine conservatively managed patients experienced a mean of 27 days ± 70 lost days (p-value < 0.001) Seven of nine conservatively managed patients were able to continue competition while undergoing treatment. Findings suggest no statistical significance regarding operative vs non-operative management of acetabular labral tears. The majority of athletes returning to sport and treated conservatively were able to resume competition during treatment. Therefore, treatment of these injuries should be individualized based on athlete’s symptoms.
Relationships between cognitive biases, decision-making, and delusions
Authors: Sheffield Julia M. , Smith Ryan , Suthaharan Praveen , Leptourgos Pantelis , Corlett Philip R. 
Published: June 2023

AbstractMultiple measures of decision-making under uncertainty (e.g. jumping to conclusions (JTC), bias against disconfirmatory evidence (BADE), win-switch behavior, random exploration) have been associated with delusional thinking in independent studies. Yet, it is unknown whether these variables explain shared or unique variance in delusional thinking, and whether these relationships are specific to paranoia or delusional ideation more broadly. Additionally, the underlying computational mechanisms require further investigation. To investigate these questions, task and self-report data were collected in 88 individuals (46 healthy controls, 42 schizophrenia-spectrum) and included measures of cognitive biases and behavior on probabilistic reversal learning and explore/exploit tasks. Of those, only win-switch rate significantly differed between groups. In regression, reversal learning performance, random exploration, and poor evidence integration during BADE showed significant, independent associations with paranoia. Only self-reported JTC was associated with delusional ideation, controlling for paranoia. Computational parameters increased the proportion of variance explained in paranoia. Overall, decision-making influenced by strong volatility and variability is specifically associated with paranoia, whereas self-reported hasty decision-making is specifically associated with other themes of delusional ideation. These aspects of decision-making under uncertainty may therefore represent distinct cognitive processes that, together, have the potential to worsen delusional thinking across the psychosis spectrum.
Influence of slope angle on deposit morphology and propagation of laboratory landslides
Authors: Wu Yan-Bin , Duan Zhao , Peng Jian-Bing , Zhang Qing , Pähtz Thomas 
Published: June 2023

AbstractLandslide deposits often exhibit surface features, such as transverse ridges and X-shaped conjugate troughs, whose physical formation origins are not well understood. To study the deposit morphology, laboratory studies typically focus on the simplest landslide geometry: an inclined plane accelerating the sliding mass immediately followed by its deceleration on a horizontal plane. However, existing experiments have been conducted only for a limited range of the slope angle θ. Here, we study the effect of θ on the kinematics and deposit morphology of laboratory landslides along a low-friction base, measured using an advanced 3D scanner. At low θ (30°–35°), we find transverse ridges formed by overthrusting on the landslide deposits. At moderate θ (40°–55°), conjugate troughs form. A Mohr–Coulomb failure model predicts the angle enclosed by the X-shaped troughs as 90° − φ, with φ the internal friction angle, in agreement with our experiments and a natural landslide. This supports the speculation that conjugate troughs form due to failure associated with a triaxial shear stress. At high θ (60°–85°), a double-upheaval morphology forms because the rear of the sliding mass impacts the front during the transition from the slope to the horizontal plane. The overall surface area of the landslides increases during their downslope motion and then decreases during their runout.
The effect of hyperbaric oxygen therapy on myocardial function in post-COVID-19 syndrome patients: a randomized controlled trial
Authors: Leitman Marina , Fuchs Shmuel , Tyomkin Vladimir , Hadanny Amir , Zilberman-Itskovich Shani , Efrati Shai 
Published: June 2023

AbstractPost-COVID-19 condition refers to a range of persisting physical, neurocognitive, and neuropsychological symptoms following SARS-CoV-2 infection. Recent evidence revealed that post-COVID-19 syndrome patients may suffer from cardiac dysfunction and are at increased risk for a broad range of cardiovascular disorders. This randomized, sham-control, double-blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT) on the cardiac function of post-COVID-19 patients with ongoing symptoms for at least three months after confirmed infection. Sixty patients were randomized to receive 40 daily HBOT or sham sessions. They underwent echocardiography at baseline and 1–3 weeks after the last protocol session. Twenty-nine (48.3%) patients had reduced global longitudinal strain (GLS) at baseline. Of them, 13 (43.3%) and 16 (53.3%) were allocated to the sham and HBOT groups, respectively. Compared to the sham group, GLS significantly increased following HBOT (− 17.8 ± 1.1 to − 20.2 ± 1.0,p = 0.0001), with a significant group-by-time interaction (p = 0.041). In conclusion, post-COVID-19 syndrome patients despite normal EF often have subclinical left ventricular dysfunction that is characterized by mildly reduced GLS. HBOT promotes left ventricular systolic function recovery in patients suffering from post COVID-19 condition. Further studies are needed to optimize patient selection and evaluate long-term outcomes.This study was registered with ClinicalTrials.gov, number NCT04647656 on 01/12/2020.
Fabrication of biochar-based superhydrophobic coating on steel substrate and its UV resistance, anti-scaling, and corrosion resistance performance
Authors: Mohamed M. E. , Adel O. , Khamis E. 
Published: June 2023

AbstractIn this study, we report an eco-friendly and facile process for the synthesis of biochar, BC, and a cobalt-biochar nanocomposite, Co-BC, using rice straw biomass. We constructed two superhydrophobic coatings on steel substrates using potentiostatic electrodeposition of nickel-modified biochar, Ni@BC, and nickel modified by cobalt-biochar nanocomposite, Ni@Co-BC, then, these coatings were soaked in an ethanolic stearic acid solution. Fourier transform infrared spectroscopy showed that the stearic acid-grafted Ni@BC coating, Ni@BC@SA, and the stearic acid-grafted Ni@Co-BC composite, Ni@Co-BC@SA, were well grafted on the steel surface. Scanning electron microscopy revealed that the superhydrophobic coatings have nanoscale features. Atomic force microscopy results showed that the Ni@Co-BC@SA coat had higher roughness than Ni@BC@SA, resulting in higher superhydrophobicity. The water contact angles for Ni@BC@SA and Ni@Co-BC@SA coatings were 161° and 165°, respectively, while the values of water sliding angles for both coatings were 3.0° and 1.0°, respectively. Quantitative estimation of the scale inhibition efficiency revealed that the Ni@Co-BC@SA coating exhibited greater efficiency compared to the Ni@BC@SA coating. Additionally, the Ni@Co-BC@SA coating demonstrated improved corrosion resistance, UV resistance, mechanical abrasion resistance, and chemical stability compared to the Ni@BC@SA coating. These results highlight the superior performance of the Ni@Co-BC@SA coating and its potential as a highly effective and durable superhydrophobic coating for steel substrates.
A correlation of the adsorption capacity of perovskite/biochar composite with the metal ion characteristics
Authors: Ali Shimaa M. , El Mansop Mohamed A. , Galal Ahmed , Abd El Wahab Soha M. , El-Etr Wafaa M. T. , Zein El-Abdeen Hanaa A. 
Published: June 2023

AbstractLaFeO3/biochar composite is prepared by cellulose-modified microwave-assisted method at 450 °C. The structure is identified by Raman spectrum which, consists of characteristics biochar bands and octahedral perovskite chemical shifts. The morphology is examined by scanning electron microscope (SEM); two phases are observed, rough microporous biochar and orthorhombic perovskite particles. The BET surface area of the composite is 57.63 m2/g. The prepared composite is applied as a sorbent for the removal of Pb2+, Cd2+, and Cu2+ions from aqueous solutions and wastewater. The adsorption ability reaches a maximum at pH > 6 for Cd2+, and Cu2+ions, and is pH-independent for Pb2+ions adsorption. The adsorption follows pseudo 2nd order kinetic model, Langmuir isotherm for Pb2+ions, and Temkin isotherms for Cd2+, and Cu2+ions. The maximum adsorption capacities,qm, are 606, 391, and 112 mg/g for Pb2+, Cd2+, and Cu2+ions, respectively. The electrostatic interaction is responsible for the adsorption of Cd2+, and Cu2+ions on LaFeO3/biochar composite. In case of Pb2+ions form a complex with the surface functional groups of the adsorbate. LaFeO3/biochar composite shows high selectivity for the studied metal ions and excellent performance in real samples. The proposed sorbent can be easily regenerated and effectively reused.
Human skin gas profile of individuals with the people allergic to me phenomenon
Authors: Sekine Yoshika , Oikawa Daisuke , Todaka Michihito 
Published: June 2023

AbstractRecent studies have shown that some people claim that their skin gases provoke allergy-like reactions in people in their near vicinity. Such a phenomenon or symptom is called ‘people allergic to me (PATM)’. Although numerous people suffer from PATM, the actual conditions are unknown. The aim of this study was to investigate the characteristics of human skin profiles in patients with PATM by measuring the dermal emission fluxes of 75 skin gases using passive flux sampler and gas chromatography/mass spectrometry. We found common features in the human skin gas profiles of 20 subjects with PATM, with a significant difference from those of 24 non-PATM subjects: greater emissions of petrochemicals, organosulfur compounds, and some aldehydes and lower emissions of aroma compounds and others. The ratio of toluene to benzaldehyde is considered a vital sign that suggests the fundamental of PATM. These findings indicate that PATM is a medically unexplained phenomenon or symptom worthy of further research, which requires an interdisciplinary approach.
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia–ischemia in newborn rats: a multi-drug randomized controlled screening trial
Authors: Sabir Hemmen , Maes Elke , Zweyer Margit , Schleehuber Yvonne , Imam Farhad B. , Silverman Jared , White Yasmine , Pang Raymand , Pasca Anca M. , Robertson Nicola J. , Maltepe Emin , Bernis Maria E. 
Published: June 2023

AbstractIntrapartum hypoxia–ischemia leading to neonatal encephalopathy (NE) results in significant neonatal mortality and morbidity worldwide, with > 85% of cases occurring in low- and middle-income countries (LMIC). Therapeutic hypothermia (HT) is currently the only available safe and effective treatment of HIE in high-income countries (HIC); however, it has shown limited safety or efficacy in LMIC. Therefore, other therapies are urgently required. We aimed to compare the treatment effects of putative neuroprotective drug candidates following neonatal hypoxic-ischemic (HI) brain injury in an established P7 rat Vannucci model. We conducted the first multi-drug randomized controlled preclinical screening trial, investigating 25 potential therapeutic agents using a standardized experimental setting in which P7 rat pups were exposed to unilateral HI brain injury. The brains were analysed for unilateral hemispheric brain area loss after 7 days survival. Twenty animal experiments were performed. Eight of the 25 therapeutic agents significantly reduced brain area loss with the strongest treatment effect for Caffeine, Sonic Hedgehog Agonist (SAG) and Allopurinol, followed by Melatonin, Clemastine, ß-Hydroxybutyrate, Omegaven, and Iodide. The probability of efficacy was superior to that of HT for Caffeine, SAG, Allopurinol, Melatonin, Clemastine, ß-hydroxybutyrate, and Omegaven. We provide the results of the first systematic preclinical screening of potential neuroprotective treatments and present alternative single therapies that may be promising treatment options for HT in LMIC.
First identification of Tyrophagus curvipenis (Acari: Acaridae) and pathogen detection in Apis mellifera colonies in the Republic of Korea
Authors: Nguyen Thi-Thu , Yoo Mi-Sun , Truong A-Tai , Lee Jong Ho , Youn So Youn , Lee Se-Ji , Kim Dong-Ho , Yoon Soon-Seek , Cho Yun Sang 
Published: June 2023

AbstractMites of the genus Tyrophagus (Acari: Acaridae) are among the most widely distributed mites. The species in this genus cause damage to stored products and crops, and pose a threat to human health. However, the influence of Tyrophagus spp. in apiculture remains unknown. In 2022, a study focusing on the identification of Tyrophagus species within five apiaries was conducted in Chungcheongnam Province, Republic of Korea. Its specific objective was to investigate the presence of Tyrophagus mites in response to the reported high mortality of honey bee colonies in this area. Morphological identification and phylogenetic analysis using the mitochondrial gene cytochrome-c oxidase subunit 1 (CO1) confirmed for the first time the presence of the mite species Tyrophagus curvipenis in a honey bee colony in the Republic of Korea. Two honey bee pathogens were detected in the mite, a viral pathogen (deformed wing virus, DWV) and a protozoal pathogen (Trypanosoma spp.). The presence of the two honey bee pathogens in the mite suggests that this mite could contribute to the spread of related honey bee diseases. However, the direct influence of the mite T. curvipenis on honey bee health remains unknown and should be further investigated.