bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Does CEO Decision Style Influence Firm Performance? The Mediating Role of Speed and Innovativeness in New Product Development
Authors: Kruse Sebastian , Bendig David , Brettel Malte 
Published: February 2023

AbstractAlthough chief executive officers (CEOs) are the primary decision‐makers in their firms, there has been little research on how CEOs' decision styles affect firm performance. This study explores the relationships between firm performance and two key dimensions of CEO decision style, namely the use of heuristics and decision standards. We conceptualize the speed and innovativeness of new product development (NPD) as mediators in these relationships. An empirical analysis of 1046 German firms indicates that CEOs' use of heuristics may lead to higher NPD speed and stronger firm performance. In addition, higher decision standards, i.e., a stronger tendency to make the best decisions possible, among CEOs may promote higher NPD speed, NPD innovativeness, and firm performance but may also lead to less use of heuristics. Our findings underscore the relevance of CEO decision styles for firm performance and NPD, contribute to the debate on the rationality of heuristics, and conceptually broaden the role of decision standards in decision‐making.
The inhibition and recovery mechanisms of the diatom Phaeodactylum tricornutum in response to high light stress – A study combining physiological and transcriptional analysis
Authors: Kan Chengxiang , Zhao Yirong , Sun Kai‐Ming , Tang Xuexi , Zhao Yan 
Published: February 2023

AbstractBy combining physiological/biochemical and transcriptional analysis, the inhibition and recovery mechanisms of Phaeodactylum tricornutum in response to extreme high light stress (1300 μmol photons · m−2 · s−1) were elucidated. The population growth was inhibited in the first 24 h and started to recover from 48 h. At 24 h, photoinhibition was exhibited as the changes of PSII photosynthetic parameters and decrease in cellular pigments, corresponding to the downregulation of genes encoding light‐harvesting complex and pigments synthesis. Changes in those photosynthetic parameters and genes were kept until 96 h, indicating that the decrease of light absorption abilities might be one strategy for photoacclimation. In the meanwhile, we observed elevated cellular ROS levels, dead cells proportions, and upregulation of genes encoding antioxidant materials and proteasome pathway at 24 h. Those stress‐related parameters and genes recovered to the controls at 96 h, indicating a stable intracellular environment after photoacclimation. Finally, genes involving carbon metabolisms were upregulated from 24 to 96 h, which ensured the energy supply for keeping high base and nucleotide excision repair abilities, leading to the recovery of cell cycle progression. We concluded that P. tricornutum could overcome photoinhibition by decreasing light‐harvesting abilities, enhancing carbon metabolisms, activating anti‐oxidative functions, and elevating repair abilities. The parameters of light harvesting, carbon metabolisms, and repair processes were responsible for the recovery phase, which could be considered long‐term adaptive strategies for diatoms under high light stress.
The deepening of the Pacific Alliance's commercial agenda: The role of policy networks in regulatory governance
Authors: Castro‐Silva Julissa 
Published: February 2023

AbstractFrom a complementary perspective to intergovernmental approaches, this article emphasizes the seldom explored role of policy networks in regional regulatory governance to explain the factors that have enhanced or limited the deepening of the Pacific Alliance's trade agenda 10 years after its launch. Within a context of a proliferation of trade agreements in Latin America, but with limited knowledge about their regulation since there are no developed countries in the agreement, it is argued that the horizontal dynamics of interaction established by trans‐governmental and transnational networks, as well as the greater articulation among them, have facilitated the deepening of a mutual working scheme. By contrast, the vertical interaction dynamics associated with a North–South economic pattern between Mexico and the other members of the bloc have placed limits on the model of deep integration designed by the group. This article is based on a multiple case study that uses process tracing to consider a process observed from the Global South, considering its particularities and overcoming state‐centric visions. Desde una perspectiva complementaria a los enfoques intergubernamentales, este trabajo enfatiza el poco explorado papel de las redes políticas en la gobernanza regulatoria regional para explicar los factores que han potenciado o limitado la profundización de la agenda comercial de la Alianza del Pacífico a diez años de su lanzamiento. En un contexto de proliferación de acuerdos comerciales en América Latina, pero de limitado conocimiento sobre su regulación en ausencia de países desarrollados, se argumenta que las dinámicas horizontales de interacción establecidas por las redes transgubernamentales y transnacionales, así como la mayor articulación entre éstas, han facilitado la profundización de un esquema de trabajo propio. En cambio, las dinámicas verticales de interacción asociadas a un patrón económico Norte–Sur entre México y los demás miembros del bloque han puesto límites al modelo de integración profunda diseñado por el grupo. Este artículo se basa en un estudio de casos múltiples que utiliza el rastreo de procesos para abordar un proceso que es observado desde el Sur Global, atendiendo sus particularidades y superando visiones estado‐céntricas.
Insoluble macromolecular organic matter in the Winchcombe meteorite
Authors: Sephton Mark A. , Chan Queenie H. S. , Watson Jonathan S. , Burchell Mark J. , Spathis Vassilia , Grady Monica M. , Verchovsky Alexander B. , Abernethy Feargus A. J. , Franchi Ian A. 
Published: February 2023

AbstractThe Winchcombe meteorite fell on February 28, 2021 in Gloucestershire, United Kingdom. As the most accurately recorded carbonaceous chondrite fall, the Winchcombe meteorite represents an opportunity to link a tangible sample of known chemical constitution to a specific region of the solar system whose chemistry can only be otherwise predicted or observed remotely. Winchcombe is a CM carbonaceous chondrite, a group known for their rich and varied abiotic organic chemistry. The rapid collection of Winchcombe provides an opportunity to study a relatively terrestrial contaminant‐limited meteoritic organic assemblage. The majority of the organic matter in CM chondrites is macromolecular in nature and we have performed nondestructive and destructive analyses of Winchcombe by Raman spectroscopy, online pyrolysis–gas chromatography–mass spectrometry (pyrolysis–GC–MS), and stepped combustion. The Winchcombe pyrolysis products were consistent with a CM chondrite, namely aromatic and polycyclic aromatic hydrocarbons, sulfur‐containing units including thiophenes, oxygen‐containing units such as phenols and furans, and nitrogen‐containing units such as pyridine; many substituted/alkylated forms of these units were also present. The presence of phenols in the online pyrolysis products indicated only limited influence from aqueous alteration, which can deplete the phenol precursors in the macromolecule when aqueous alteration is extensive. Raman spectroscopy and stepped combustion also generated responses consistent with a CM chondrite. The pyrolysis–GC–MS data are likely to reflect the more labile and thermally sensitive portions of the macromolecular materials while the Raman and stepped combustion data will also reflect the more refractory and nonpyrolyzable component; hence, we accessed the complete macromolecular fraction of the recently fallen Winchcombe meteorite and revealed a chemical constitution that is similar to other meteorites of the CM group.
PDZ‐binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells
Authors: Kato Mikako , Ota Akinobu , Ono Takayuki , Karnan Sivasundaram , Hyodo Toshinori , Rahman Md Lutfur , Hasan Muhammad Nazmul , Onda Maho , Kondo Sayuri , Ito Kunihiro , Furuhashi Akifumi , Hayashi Tomio , Konishi Hiroyuki , Tsuzuki Shinobu , Hosokawa Yoshitaka , Kazaoka Yoshiaki 
Published: February 2023

AbstractObjectivePDZ‐binding kinase (PBK) has been reported as a poor prognostic factor and is a promising molecular target for anticancer therapeutics. Here, we aimed to investigate the effect of specific PBK inhibitor OTS514 on the survival of OSCC cells.MethodsFour OSCC cell lines (HSC‐2, HSC‐3, SAS, and OSC‐19) were used to examine the effect of OTS514 on cell survival and apoptosis. DNA microarray analysis was conducted to investigate the effect of OTS514 on gene expression in OSCC cells. Gene set enrichment analysis was performed to identify molecular signatures related to the antiproliferative effect of OTS514.ResultsOTS514 decreased the cell survival of OSCC cells dose‐dependently, and administration of OTS514 readily suppressed the HSC‐2‐derived tumor growth in immunodeficient mice. Treatment with OTS514 significantly increased the number of apoptotic cells and caspase‐3/7 activity. Importantly, OTS514 suppressed the expression of E2F target genes with a marked decrease in protein levels of E2F1, a transcriptional factor. Moreover, TP53 knockdown attenuated OTS514‐induced apoptosis.ConclusionOTS514 suppressed the proliferation of OSCC cells by downregulating the expression of E2F target genes and induced apoptosis by mediating the p53 signaling pathway. These results highlight the clinical application of PBK inhibitors in the development of molecular‐targeted therapeutics against OSCC.
Success with a twinge of distress: Antecedents and consequences of outperformance‐related discomfort
Authors: Koch Erika J. 
Published: February 2023

AbstractAlthough outperforming others brings intrapersonal benefits, it may also carry interpersonal costs. The term Sensitivity about being the Target of a Threatening Upward Comparison (STTUC) captures the discomfort that outperformers may feel when they perceive that their success upsets an outperformed person. This paper reviews 20+ years of research on STTUC. It begins by defining STTUC and its three essential criteria. It then delineates situation and person variables that explain variability in STTUC. It follows by describing outperformers' varied reactions to STTUC and then explains the potential social function of STTUC.
Miocene ductile thinning below the Folegandros Detachment System, Cyclades, Greece
Authors: Bakowsky C. , Schneider D.A. , Grasemann B. , Soukis K. 
Published: February 2023

AbstractFolegandros island lies between the established SW‐directed West Cycladic and S‐directed Santorini detachment systems. Preserving shear‐sense indicators with opposing kinematics, the geodynamics and timing of kinematics are debated. Using white mica 40Ar/39Ar geochronology complemented by structural data, we report a new Miocene top‐to‐S detachment system, the Folegandros Detachment System (FDS), that is coupled with pure‐shear flattening and juxtaposes the Cycladic Blueschist Unit below Early Cretaceous to early Eocene low‐grade marble and quartzitic‐phyllitic sequences, topped by a metaflysch. Chronostratigraphic correlation and detrital zircon geochronology reveal the low‐grade rocks from the hanging wall of the FDS likely belong to the Pelagonian Zone. Middle Miocene zircon and apatite (U‐Th)/He cooling ages correspond to the latest stages of exhumation. Observations of opposing kinematics on Sikinos, Ios and now Folegandros reveal that ductile thinning played a more significant role in accommodating Miocene exhumation of high‐pressure rocks in the southern Cyclades than previously postulated.
Motivations for blood donation by HIV‐positive individuals on antiretrovirals in South Africa: A qualitative study
Authors: van den Berg Karin , Murphy Edward L. , Louw Vernon J. , Maartens Gary , Hughes Shana D. 
Published: February 2023

AbstractObjectivesWe performed a mixed‐methods study to explore the motivations associated with blood donation by donors with known, but undisclosed HIV‐positive status and ARV use (HIV+/ARV+), seeking potential strategies to reduce such donations and mitigate risk for blood recipients. Here, we report predominantly the qualitative component.BackgroundA safe and sustainable blood supply is dependent in part, on effective pre‐donation donor assessment. We previously described failure by HIV+/ARV+ blood donors to disclose their status. Such donations may lead to transfusion‐transmitted HIV.MethodsThe social ecological model provided the conceptual framework for this study. Previously identified HIV+/ARV+ donors were invited to complete a survey (including a validated stigma scale) and qualitative interview, which underwent inductive and deductive thematic analysis.ResultsWe uncovered two primary motivational paths to HIV+/ARV+ blood donations: privacy and altruism. The latter included a motivation not previously reported in the literature: donating specifically for other people living with HIV (PLWH). The other primary factor was a lack of privacy. These accounts often included donors encountering donation opportunities when accompanied by people to whom they had not and did not plan to disclose their HIV status. Most were highly confident their donations would be identified as HIV‐positive and discarded.ConclusionWe demonstrated a complex interaction between individual, social, cultural, and structural/policy factors in blood donations by PLWH who take ARV. Recommendations to limit HIV + ARV+ donations include: (1) Targeted communication strategies to increase knowledge among PLWH of their deferral from blood donation—without increasing stigma, and (2) development of procedures to assist those who feel unable to opt‐out of donation due to privacy concerns.
Puncta‐localized TRAF domain protein TC1b contributes to the autoimmunity of snc1
Authors: Ao Kevin , Rohmann Philipp F. W. , Huang Shuai , Li Lin , Lipka Volker , Chen She , Wiermer Marcel , Li Xin 
Published: February 2023

SUMMARYImmune receptors play important roles in the perception of pathogens and initiation of immune responses in both plants and animals. Intracellular nucleotide‐binding domain leucine‐rich repeat (NLR)‐type receptors constitute a major class of receptors in vascular plants. In the Arabidopsis thaliana mutant suppressor of npr1‐1, constitutive 1 (snc1), a gain‐of‐function mutation in the NLR gene SNC1 leads to SNC1 overaccumulation and constitutive activation of defense responses. From a CRISPR/Cas9‐based reverse genetics screen in the snc1 autoimmune background, we identified that mutations in TRAF CANDIDATE 1b (TC1b), a gene encoding a protein with four tumor necrosis factor receptor‐associated factor (TRAF) domains, can suppress snc1 phenotypes. TC1b does not appear to be a general immune regulator as it is not required for defense mediated by other tested immune receptors. TC1b also does not physically associate with SNC1, affect SNC1 accumulation, or affect signaling of the downstream helper NLRs represented by ACTIVATED DISEASE RESISTANCE PROTEIN 1‐L2 (ADR1‐L2), suggesting that TC1b impacts snc1 autoimmunity in a unique way. TC1b can form oligomers and localizes to punctate structures of unknown function. The puncta localization of TC1b strictly requires its coiled‐coil (CC) domain, whereas the functionality of TC1b requires the four TRAF domains in addition to the CC. Overall, we uncovered the TRAF domain protein TC1b as a novel positive contributor to plant immunity.
Refractory shock, hypercoagulability, and multiorgan thrombosis associated with hypertrophic osteodystrophy in a dog
Authors: Perry Kayla M. , Enders Brittany D. , Negrão Watanabe Tatiane Terumi 
Published: February 2023

AbstractObjectiveTo describe the clinical findings and case progression in a dog presenting with severe systemic inflammatory response, refractory shock, progressive metabolic acidosis, and respiratory failure that was ultimately diagnosed with hypertrophic osteodystrophy (HOD).Case SummaryA 4‐month‐old male intact Mastiff presented with a 24‐hour history of lethargy and generalized ostealgia. On examination, the dog was recumbent, febrile, and tachycardic with pain on palpation of the abdomen, right femur, and mandible. Appendicular joint radiographs showed changes consistent with osteochondrosis and ulnar‐retained cartilaginous cores, with no overt evidence of HOD. Initial treatment included IV fluid therapy, multimodal analgesia, and broad‐spectrum antimicrobials. Vasopressor therapy was initiated following hemodynamic decompensation. Synovial fluid cytological analysis and culture revealed nonseptic suppurative inflammation and no bacterial growth, respectively. Blood and urine cultures also yielded no growth. Viscoelastic testing was consistent with hypercoagulability. The dog initially had a metabolic acidosis with appropriate respiratory compensation that progressed to a mixed metabolic and respiratory acidosis despite aggressive therapies that included antimicrobials, vasopressors, positive inotropes, and corticosteroids. Humane euthanasia was elected approximately 32 hours after admission. Necropsy yielded a diagnosis of HOD.New or Unique Information ProvidedThis is the first report detailing the occurrence of refractory shock and hypercoagulability associated with HOD in a dog without evidence of another identified comorbidity. HOD should be considered in any young, large‐breed dog with generalized ostealgia and signs of systemic illness, even in the absence of classic radiographic abnormalities. Further investigation of coagulation status in dogs with HOD and a secondary systemic inflammatory response is warranted.
Duration of neuromuscular block is more variable and recovery time is shorter with rocuronium than cisatracurium in anesthetized dogs
Authors: Martin‐Flores Manuel , Hackman Megan C. , Araos Joaquin D. , Campoy Luis , Gleed Robin D. 
Published: February 2023

AbstractObjectiveTo compare the variability in the duration of action of a single dose of rocuronium or cisatracurium, and duration of subsequent top‐up doses in anesthetized dogs.AnimalsThirty dogs requiring ophthalmic surgery with neuromuscular block.ProceduresNeuromuscular function was monitored with train‐of‐four (TOF) and acceleromyography. Dogs received an initial dose of rocuronium 0.6 mg/kg, or cisatracurium 0.15 mg/kg IV, which produced complete neuromuscular block. Upon return of the first response (T1) of TOF, a third of the initial dose was repeated. The duration of the initial dose and its variability were compared between agents. Duration of subsequent top‐up doses was assessed with mixed effect models. Spontaneous (from last return of T1) or neostigmine‐enhanced (from administration to complete recovery) recovery times were measured for each agent.ResultsDuration of action of the initial dose was [median (range)] 25 (10–60) min with rocuronium and 35 (15–45) min with cisatracurium (p = .231). The variability of rocuronium was 3.25 times larger than cisatracurium (p = .034). Duration of top‐up doses did not vary for either agent. Spontaneous recovery was shorter for rocuronium [15 (10–20) min] than cisatracurium [25 (15–45) min] (p = .02). Neostigmine‐enhanced recovery times were 5 (5–25) for rocuronium and 10 (5–10) for cisatracurium (p = .491).ConclusionsDuration of action for a single dose is significantly more variable with rocuronium than cisatracurium. Time to spontaneous recovery was longer for cisatracurium, and cases of unexpectedly long recovery times were observed with both agents. Objective monitoring is recommended.
On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart
Authors: Kadir Azrul Abdul , Stubbs Brianna J. , Chong Cher‐Rin , Lee Henry , Cole Mark , Carr Carolyn , Hauton David , McCullagh James , Evans Rhys D. , Clarke Kieran 
Published: February 2023

AbstractIn heart, glucose and glycolysis are important for anaplerosis and potentially therefore for d‐β‐hydroxybutyrate (βHB) oxidation. As a glucose store, glycogen may also furnish anaplerosis. We determined the effects of glycogen content on βHB oxidation and glycolytic rates, and their downstream effects on energetics, in the isolated rat heart. High glycogen (HG) and low glycogen (LG) containing hearts were perfused with 11 mM [5‐3H]glucose and/or 4 mM [14C]βHB to measure glycolytic rates or βHB oxidation, respectively, then freeze‐clamped for glycogen and metabolomic analyses. Free cytosolic [NAD+]/[NADH] and mitochondrial [Q+]/[QH2] ratios were estimated using the lactate dehydrogenase and succinate dehydrogenase reaction, respectively. Phosphocreatine (PCr) and inorganic phosphate (Pi) concentrations were measured using 31P‐nuclear magnetic resonance spectroscopy. Rates of βHB oxidation in LG hearts were half that in HG hearts, with βHB oxidation directly proportional to glycogen content. βHB oxidation decreased glycolysis in all hearts. Glycogenolysis in glycogen‐replete hearts perfused with βHB alone was twice that of hearts perfused with βHB and glucose, which had significantly higher levels of the glycolytic intermediates fructose 1,6‐bisphosphate and 3‐phosphoglycerate, and higher free cytosolic [NAD+]/[NADH]. βHB oxidation increased the Krebs cycle intermediates citrate, 2‐oxoglutarate and succinate, the total NADP/H pool, reduced mitochondrial [Q+]/[QH2], and increased the calculated free energy of ATP hydrolysis (∆GATP). Although βHB oxidation inhibited glycolysis, glycolytic intermediates were not depleted, and cytosolic free NAD remained oxidised. βHB oxidation alone increased Krebs cycle intermediates, reduced mitochondrial Q and increased ∆GATP. We conclude that glycogen facilitates cardiac βHB oxidation by anaplerosis.
imageKey points
Ketone bodies (d‐β‐hydroxybutyrate, acetoacetate) are increasingly recognised as important cardiac energetic substrates, in both healthy and diseased hearts.
As 2‐carbon equivalents they are cataplerotic, causing depletion of Krebs cycle intermediates; therefore their utilisation requires anaplerotic supplementation, and intra‐myocardial glycogen has been suggested as a potential anaplerotic source during ketone oxidation.
It is demonstrated here that cardiac glycogen does indeed provide anaplerotic substrate to facilitate β‐hydroxybutyrate oxidation in isolated perfused rat heart, and this contribution was quantified using a novel pulse–chase metabolic approach.
Further, using metabolomics and 31P‐MR, it was shown that glycolytic flux from myocardial glycogen increased the heart's ability to oxidise βHB, and βHB oxidation increased the mitochondrial redox potential, ultimately increasing the free energy of ATP hydrolysis.