bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutational spectrum of HBD gene in the Chinese population: Description of 36 mutations including 11 novel variants
Authors: Xu Anping , Li Mingyang , Ye Yinghui , Li Liping , Ma Minjing , Wu Shang Ying , Ji Ling 
Published: August 2023

AbstractIntroductionMutations in the hemoglobin subunit delta (HBD) gene (MIM#142000) are associated with decreased levels of the Hemoglobin A2 (Hb A2) fraction. We aimed to examine the prevalence of HBD gene mutations and summarize their characteristics in the Chinese population.MethodsIndividuals who exhibited Hb A2 levels below 1.8%, with or without Hb A2 variant peaks, were chosen for further investigation. Hemoglobin analysis was conducted using capillary electrophoresis. Common α and β‐thalassemia in China were detected using gap‐PCR and reverse dot blot hybridization. The presence of HBD gene mutations was confirmed by DNA sequencing.ResultsA total of 188 patients were identified as carriers of the HBD gene mutation, with a prevalence of approximately 0.46%. We discovered 36 types of mutations, 30 of which resulted in δ‐globin variants, while the remaining 6 resulted in δ‐thalassemia. The most common mutation was HBD:c.‐127 T > C, accounting for 87.2% of δ‐thalassemia cases. In addition, we identified 11 novel HBD gene mutations and found 10 cases compounded with other common thalassemias.ConclusionWe observed a high prevalence of HBD gene mutations in southern China. Our findings provide a genetic basis for screening for δ‐thalassemia and enrich the spectrum of HBD gene mutations.
Identification of tumor immunophenotypes associated with immunotherapy response in bladder cancer
Authors: Liang Hai‐qi , Liao Nai‐kai , Yang Shu‐bo , Wei Qiu‐ju , Tan Shu‐ting , Zhai Gao‐qiang , Lu Jiang‐ting , Huang Yi‐cheng , Deng Xiao‐bin , Mo Lin‐jian , Cheng Ji‐wen 
Published: August 2023

ObjectivesThis study aims to reveal immunophenotypes associated with immunotherapy response in bladder cancer, identify the signature genes of immune subtypes, and provide new molecular targets for improving immunotherapy response.MethodsBladder cancer immunophenotypes were characterized in the bulk RNA sequencing dataset GSE32894 and Imvigor210, and gene expression signatures were established to identify the immunophenotypes. Expression of gene signatures were validated in single‐cell RNA sequencing dataset GSE145140 and human proteins expression data source. Investigation of Immunotherapy Response was performed in IMvigor210 dataset. Prognosis of tumor immunophenotypes was further analyzed.ResultsInflamed and immune‐excluded immunophenotypes were characterized based on the tumor immune cell scores. Risk score models that were established rely on RNA sequencing profiles and overall survival of bladder cancer cohorts. The inflamed tumors had lower risk scores, and the low‐risk tumors were more likely to respond to atezolizumab, receiving complete response/partial response (CR/PR). Patients who responded to atezolizumab had higher SRRM4 and lower NPHS1 and TMEM72 expression than the non‐responders. SRRM4 expression was a protective factor for bladder cancer prognosis, while the NPHS1 and TMEM72 showed the opposite pattern.ConclusionThis study provided a novel classification method for tumor immunophenotypes. Bladder cancer immunophenotypes can predict the response to immune checkpoint blockade. The immunophenotypes can be identified by the expression of signature genes.
Historical epidemics of scrub typhus in Queensland and Papua New Guinea
Authors: Shanks G. D. 
Published: August 2023

AbstractUndifferentiated febrile diseases (e.g., Mossman fever) from northern Queensland were eventually partially attributed to mite‐transmitted rickettsial infections known as scrub typhus or tsutsugamushi fever. Scrub typhus became a major medical threat to military operations in Papua New Guinea during the Second World War and killed more Australian soldiers than malaria in the pre‐antibiotic era. Further investigations showed scrub typhus to be an occupational disease of rural workers in north Queensland especially around Cairns and Innisfail. Occasional small epidemics of scrub typhus still occur during military exercises in Queensland, but as scrub typhus is not a reportable disease, its presence in the civilian community is largely unknown. Increased use of serological testing in patients with fever and rash illnesses after exposure in northern Queensland is likely to show that scrub typhus is a modern infection that remains treatable with antibiotics once it is identified.
TAM receptors in phagocytosis: Beyond the mere internalization of particles
Authors: Burstyn‐Cohen Tal , Fresia Roberta 
Published: August 2023

SummaryTYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, activated by their ligands GAS6 and PROS1. TAMs are necessary for adult homeostasis in the immune, nervous, reproductive, skeletal, and vascular systems. Among additional cellular functions employed by TAMs, phagocytosis is central for tissue health. TAM receptors are dominant in providing phagocytes with the molecular machinery necessary to engulf diverse targets, including apoptotic cells, myelin debris, and portions of live cells in a phosphatidylserine‐dependent manner. Simultaneously, TAMs drive the release of anti‐inflammatory and tissue repair molecules. Disruption of the TAM‐driven phagocytic pathway has detrimental consequences, resulting in autoimmunity, male infertility, blindness, and disrupted vascular integrity, and which is thought to contribute to neurodegenerative diseases. Although structurally and functionally redundant, the TAM receptors and ligands underlie complex signaling cascades, of which several key aspects are yet to be elucidated. We discuss similarities and differences between TAMs and other phagocytic pathways, highlight future directions and how TAMs can be harnessed therapeutically to modulate phagocytosis.
Development and validation of a youth climate anxiety scale for the Youth Development Instrument survey
Authors: Wu Judy , Long David , Hafez Nada , Maloney Jacqueline , Lim Yan , Samji Hasina 
Published: August 2023

AbstractEmerging terms in the literature such as climate anxiety describe heightened concern, fear, and anxiety related to the climate crisis. Recent efforts have attempted to develop and validate scales to measure climate anxiety; however, extant research is largely focused on adults. Consequently, it is unclear whether developed measures are appropriate for adolescent populations, despite disproportionate impacts of the climate crisis experienced by this age group. The purpose of this study was two‐fold; first, we aimed to assess levels of climate concern among Canadian adolescents using the Youth Development Instrument (YDI), a population‐level youth well‐being survey administered in schools with students (ages 15–18). Secondly, we collaborated with adolescents to adapt an existing climate anxiety scale to be included in the YDI survey. We used survey results to validate the adapted scale for use with adolescents and assessed levels of climate anxiety within our sample. In consultation with adolescents, the 13‐item Climate Change Anxiety Scale (CCAS) was adapted to create the Climate Change Anxiety Scale – Short‐form (CCAS‐S) which consists of four‐items adapted from the original CCAS. A total of 2306 respondents were included in analyses. Most adolescents reported feeling climate change concern (75.8%). A smaller proportion reported experiences of climate anxiety (48.7%). Confirmatory factor analysis supported a one‐factor structure for the CCAS‐S, with high internal consistency (Cronbach's alpha = 0.95) and good model fit with error co‐variance. Findings from this study provide construct validity evidence and reliability for the use of the CCAS‐S in adolescent populations.
Organizational display rules in nursing: Impacts on caring behaviors and emotional exhaustion through emotional labor
Authors: Qiu Pingping , Yan Liting , Zhang Qianmin , Guo Shengbin , Liu Chenyin , Liu Huijing , Chen Xinchen 
Published: August 2023

AbstractAimTo examine the impact of display rules on nurses’ caring behaviors and emotional exhaustion and the mediating role of emotional labor (surface/deep acting).BackgroundHospitals often implement emotional display rules for nurses with the expectation of performance benefits. However, these rules may have an impact on nurses' caring behaviors and emotional exhaustion.MethodsThis cross‐sectional correlational study included a sample of 746 nurses from five hospitals and used the STROBE checklist. Relationships between display rules, emotional labor, caring behaviors, and emotional exhaustion were analyzed using structural equation modeling.ResultsDisplay rules did not directly affect caring behaviors or emotional exhaustion. Emotional labor mediated the relationships. Display rules were associated more with surface acting. Deep acting increased caring behaviors and reduced emotional exhaustion; surface acting had the opposite effect.ConclusionsFindings challenge the assumption that display rules effectively promote caring behaviors. Display rules lead to emotional labor and emotional exhaustion. Reducing display rules, emotional labor, and surface acting while supporting deep acting may alleviate emotional exhaustion.Implications for nursing and health policyNurse managers should review the nature and implementation of emotional display rules and explore ways to reduce emotional labor, encourage deep acting, mitigate the negative impact of surface acting, and ultimately improve nursing caring behaviors.
RETRACTED: Diabetic foot wound ulcer management by laser therapy: A meta‐analysis
Authors: Liu He , Ya‐Qing Xia , Cai‐Feng Yang , Jia‐Li He , Xian‐Yu Tang 
Published: August 2023

AbstractA meta‐analysis examination was implemented to review diabetic foot wound ulcer (DFWU) management by laser therapy (LT). A broad literature examination until May 2023 was done and 1357 interconnected examinations were revised. The 26 elected examinations, enclosed 1067 personals with DFWU were in the utilized examinations ‘starting point, 540 of them were utilizing LT, and 527 were utilizing control. Odds ratio (OR) and 95% confidence intervals (CIs) were utilized to appraise the DFWUs management by LT by the dichotomous and continuous approach and a fixed or random model. LT had significantly higher ulcer size decreases (MD, 17.04; 95% CI, 12.48–21.59, p < 0.001) with high heterogeneity (I2 = 99%), and complete healing rate (OR, 2.88; 95% CI, 1.89–4.37, p < 0.001) with no heterogeneity (I2 = 0%) compared with control in personals with DFWU. LT had significantly higher ulcer size decreases, and complete healing rate compared to control in personals with DFWU. Nevertheless, exercise caution while interacting with its values since all the chosen examinations were found with a low sample size for the comparisons in the meta‐analysis.
Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings
Authors: Das Nabarun Chandra , Chakraborty Pritha , Nandy Samapika , Dey Abhijit , Malik Tabarak , Mukherjee Suprabhat 
Published: August 2023

AbstractMore than half a century has passed since the introduction of the National Filariasis Control Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in the tropical and subtropical regions, posing a substantial challenge to the objective of worldwide elimination. LF is affecting human beings and its economically important livestock leading to a crucial contributor to morbidities and disabilities. The current scenario has been blowing up alarms of attention to develop potent therapeutics and strategies having efficiency against the adult stage of filarial nematodes. In this context, the exploration of a suitable drug target that ensures lethality to macro and microfilariae is now our first goal to achieve. Apoptosis has been the potential target across all three stages of filarial nematodes viz. oocytes, microfilariae (mf) and adults resulting in filarial death after receiving the signal from the reactive oxygen species (ROS) and executed through intrinsic and extrinsic pathways. Hence, it is considered a leading target for developing antifilarial drugs. Herein, we have shown the efficacy of several natural and synthetic compounds/nanoformulations in triggering the apoptotic death of filarial parasites with little or no toxicity to the host body system.
Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea‐treated KCNJ11 neonatal diabetes
Authors: Bowman Pamela , Patel Kashyap A , McDonald Timothy J , Holst Jens J , Hartmann Bolette , Leveridge Maria , Shields Beverley M , Hammersley Suzie , Spaull Steve R , Knight Bridget A , Flanagan Sarah E , Shepherd Maggie H , Andrews Rob C , Hattersley Andrew T 
Published: August 2023

AbstractThe incretin hormones glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (SU)‐treated KCNJ11 permanent neonatal diabetes. The aim of this study was to assess for the first time the incretin hormone response to carbohydrate and protein/fat in adults with sulfonylurea‐treated KCNJ11 permanent neonatal diabetes compared with that of controls without diabetes. Participants were given a breakfast high in carbohydrate and an isocaloric breakfast high in protein/fat on two different mornings. Incremental area under the curve and total area under the curve (0‐240 minutes) for total GLP‐1 and GIP were compared between groups, using non‐parametric statistical methods. Post‐meal GLP‐1 and GIP secretion were similar in cases and controls, suggesting this process is adenosine triphosphate‐sensitive potassium channel‐independent. Future research will investigate whether treatments targeting the incretin pathway are effective in individuals with KCNJ11 permanent neonatal diabetes who do not have good glycemic control on sulfonylurea alone.
Monetary and Macroprudential Policy and Welfare in an Estimated Four‐Agent New Keynesian Model
Authors: BRATSIOTIS GEORGE J. , PATHIRAGE KASUN D. 
Published: August 2023

AbstractWe examine the social and agent‐specific welfare effects of monetary and macroprudential policy in a four‐agent estimated macro‐economic model comprising “banked simple households,” “underbanked simple households,” “firm owners,” and “bank owners.” Optimal capital requirement and loan loss provisions ratios improve all agent‐specific and social welfare, but imply smaller gains for simple households and firm owners that rely on credit. Countercyclical capital buffers support firm owners and bank owners with smaller gains for the two simple households, while countercyclical loan loss provisions improve social welfare only for specific shocks. Coordination between monetary and macroprudential policies yields higher social welfare than no coordination.
Dental anxiety and ageing anxiety: Moderated mediation roles of Oral Health‐Related Quality of Life and subjective accelerated ageing
Authors: Shacham Maayan , Ben‐Ezra Menachem , Hamama‐Raz Yaira , Palgi Yuval , Greenblatt‐Kimron Lee 
Published: August 2023

AbstractBackgroundOral health and its relation to ageing is an important topic often neglected among geriatric populations. Proper oral rehabilitation may aid in alleviating mental health burdens in such populations.ObjectivesThe present study aimed to explore the association between dental anxiety and ageing anxiety, with regard to the interplay of Oral Health‐Related Quality of Life (OHRQoL) as mediator and subjective accelerated ageing as a moderator.MethodsA total of 577 participants with mean age 72.78 years (SD = 3.832, range = 68–87) were recruited via a survey company in Israel. They completed a self‐report battery of questionnaires about dental anxiety, OHRQoL, subjective accelerated ageing and ageing anxiety, along with their informed consent.ResultsThe findings revealed that dental anxiety was positively associated with ageing anxiety (direct effect), and that OHRQoL mediated the link between dental anxiety and ageing anxiety (indirect effect). Additionally, subjective accelerated ageing moderated the positive link between dental anxiety and OHRQoL, as well as the positive link between OHRQoL and ageing anxiety.ConclusionsThe results provide insight for the roles of OHRQoL and subjective accelerated ageing among older adults between dental anxiety and ageing anxiety. Tailoring oral rehabilitation interventions that focus on these factors are warranted to improve older adults' dental health.
Domestic and international factors of the contemporary Russo–Venezuelan bilateral relationship
Authors: Boersner Herrera Adriana , Haluani Makram 
Published: August 2023

AbstractThis article offers an analysis of the domestic and international factors shaping the Russo–Venezuelan alliance. We provide a comprehensive analysis to understand the evolution of this alliance and to consider how the political leadership, the regime type, the military sector, the economy, and the presence of China and the United States in Latin America are vital determinants in this alliance. At the policy level, Russia and Venezuela's relationship has opened an opportunity for the Venezuelan government to consolidate power, while for Russia, this alliance has helped offset the influence of the United States in Latin America.
Large X‐effects are absent in torrent frogs with nascent sex chromosomes
Authors: Wang Ziwen , Luo Wei , Ping Jun , Xia Yun , Ran Jianghong , Zeng Xiaomao 
Published: August 2023

AbstractSex chromosomes are popularized as a special role in driving speciation. However, the empirical evidence from natural population processes has been limited to organisms with degenerated sex chromosomes, where hemizygosity is mainly considered to act as the driver of reproductive isolation. Here, we examined several hybrid zones of torrent frog Amolops mantzorum species complex, using an approach by mapping species‐diagnostic loci onto the reference genome to compare sex‐linked versus autosomal patterns of introgression. We find little support in sex‐linked incompatibilities for large X‐effects for these populations in hybrid zones with homomorphic sex chromosomes, due to the absence of the hemizygous effects. As expected, the large X‐effects were not found in those with heteromorphic but newly evolved sex chromosomes, owing to the absence of strong genetic differences between X and Y chromosomes. The available data so far on amphibians suggest little role for sex‐linked genes in speciation. The large X‐effects in those with nascent sex chromosomes may not be as ubiquitous as presumed across the animal kingdom.
Negation in Poetics and Theology
Authors: Milbank John 
Published: August 2023

AbstractThere is a certain parallel between ‘negative capability’ in poetics and negation in theology. However, the former should be understood after Coleridge, not Keats, as blending empathetic self‐estrangement with expressive subjective involvement. Yet this only makes sense in terms of a participation in the transcendent. Similarly, negation in mystical theology is one moment in oscillation with the cataphatic. Negative theology, so understood, only makes sense at all within a broadly Neoplatonic metaphysical framework, as can be shown both historically and conceptually. Neither phenomenological nor grammatical approaches to negation are by comparison sufficient, though they have their supplementary illuminating place. Today, however, we need to supplement the Neoplatonic metaphysical framework with a stronger sense that the mystical approach to God involves in itself our poetic activity which inversely has to be understood as participative.
An interplay between bZIP16, bZIP68, and GBF1 regulates nuclear photosynthetic genes during photomorphogenesis in Arabidopsis
Authors: Norén Lindbäck Louise , Ji Yan , Cervela‐Cardona Luis , Jin Xu , Pedmale Ullas V. , Strand Åsa 
Published: August 2023

Summary

The development of a seedling into a photosynthetically active plant is a crucial process. Despite its importance, we do not fully understand the regulatory mechanisms behind the establishment of functional chloroplasts.

We herein provide new insight into the early light response by identifying the function of three basic region/leucine zipper (bZIP) transcription factors: bZIP16, bZIP68, and GBF1. These proteins are involved in the regulation of key components required for the establishment of photosynthetically active chloroplasts. The activity of these bZIPs is dependent on the redox status of a conserved cysteine residue, which provides a mechanism to finetune light‐responsive gene expression.

The blue light cryptochrome (CRY) photoreceptors provide one of the major light‐signaling pathways, and bZIP target genes overlap with one‐third of CRY‐regulated genes with an enrichment for photosynthesis/chloroplast‐associated genes. bZIP16, bZIP68, and GBF1 were demonstrated as novel interaction partners of CRY1. The interaction between CRY1 and bZIP16 was stimulated by blue light. Furthermore, we demonstrate a genetic link between the bZIP proteins and cryptochromes as the cry1cry2 mutant is epistatic to the cry1cry2bzip16bzip68gbf1 mutant.

bZIP16, bZIP68, and GBF1 regulate a subset of photosynthesis associated genes in response to blue light critical for a proper greening process in Arabidopsis.
Group‐identification, collectivism, and perspectival autonomy
Authors: Zahavi Dan 
Published: August 2023

AbstractOne of the aims of the 40th Annual Spindel Conference was to discuss whether the ongoing, but relatively distinct, investigations of relational autonomy and collective intentionality could crossfertilize. Whereas the concept of relational autonomy was developed to do justice to the relational character of selfhood, and as an alternative to traditional conceptions of autonomy, which were accused of exaggerating the self‐reliance and social independence of the self, recent discussions of collective intentionality have often centered on the question of whether and how collective intentions differ from aggregations of individual intentions. As different as they might otherwise be, theoretical explorations of autonomy and collective intentionality intersect at a crucial point: both require an understanding of the relationship between the self and the group, between individual subjectivity and social life. The aim of the following paper is to argue that the collective intentionality literature contains insights that cannot merely contribute to our understanding of autonomy, but also prevent us from taking our relationism too far.