bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN MEMBATIK TEKNIK ECOPRINT BAGI IBU PKK KELURAHAN MERJOSARI KECAMATAN LOWOKWARU KOTA MALANG
Authors: Utaminingsih Alifiulahtin , Wike Wike , Nurani Farida 
Published: January 2023

Wirausahawan sukses harus memliki jiwa berwirausaha yang kuat, karenanya senantiasa berfikir dan bertindak kreatif dan inovatif. Seorang wirausaha bisa terbentuk karena bakat atau dari proses karena pengaruh lingkungan, sehingga memunculkan pengetahuan, sikap serta pengembangan keterampilan, yang pada umumnya memiliki ciri-ciri: gemar berusaha, tegar walaupun gagal, percaya diri, memiliki self determination atau locus of control yang baik, berani menanggung segala risiko, serta memandang perubahan sebagai suatu tantangan dan peluang. Ibu-ibu PKK Kelurahan Merjosari Kecamatan Lowokwaru Kabupaten Malang berada dalam lingkungan yang mendukung dari aspek sumber daya manusia untuk dilaksanakan pelatihan membatik dengan teknik shibori yang tujuannya adalah meningkatkan pendapatan serta mengisi waktu luang dengan kegiatan yang bermanfaat,.. Hal ini karena alat-alat mudah didapatkan dan bahan-bahan untuk pelatihan cukup terjangkau Permasalahan yang ditemukan adalah belum optimalnya pengembangan life skill berupa peningkatan keterampilan ibu-ibu PKK, oleh sebab itu perlu untuk dilakukan pengembangan kapasitas diri bagi ibu-ibu PKK Politeknik Negeri Malang dengan menumbuhkan jiwa wirausaha berbasis ekonomi kreatif dan inovatif yang bernilai ekonomis, yang dilakukan melalui keterampilan membatik shibori. Shibori merupakan teknik membuat motif batik yang dilakukan khas Jepang, yang hampir sama dengan produk yang lain di Indonesia, seperti batik sasirangan, batik ikat dan lain-lain. Ada berbagai teknik shibori yang bisa dipelajari sehingga kedepannya mampu menciptakan wirausaha perempuan yang handal guna meningkatkan pendapatan keluarga.
BIMBINGAN TEKNIS TAMPILAN JADWAL SHOLAT DI MUSHOLLA AL-KHOIR DESA TEGAL WERU KABUPATEN MALANG
Authors: Kamajaya Leonardo , Fitri Fitri , Palupi Lucky Nindya , Mandayatma Eka , Nurcahyo Sidik , Sumarno Agus Sukoco Heru , Nisa Fauziah Sholikhatun 
Published: January 2023

This activity aims to design an information system that contains prayer time schedules and other important information that is very useful for musholla Al-Khoir pilgrims. The purpose of the activity is to provide technical guidance to the mosque administrators. The result of this activity is that people in the Tegal Weru area become easier to find out the prayer schedule and other important information related to worship activities
Pengadaan Alat Produksi Guna Meningkatkan Produksi DUPITOS di Dusun Petung Sewu Kabupaten Malang
Authors: Widiyowati Eny , Suryanto Bambang , Sulasari Ayu , Masrevastuti Masrevastuti 
Published: January 2023

Abstract
Dusun Petungsewu is one of the hamlets producing quality corn gerit. The product diversification that has been carried out is in the form of tortilla chips, which are named Dupitos (Duwet Polinema Tortilla Chips). The production is carried out by the people of Dusun Petungsewu. The potential possessed by Dusun Petungsewu by processing Dupitos is quite large. This is because Dupitos products are healthy snacks that are suitable for consumption by all ages. Currently, Dupitos' production process still uses inadequate equipment. Therefore, this service aims to donate the equipment needed in the Dupitos production process so that the production process can run smoothly. The implementation of community service programs is carried out in the form of production equipment grants, knowledge transfer, questions and answers and evaluations. The results of the service show that the procurement of production equipment in the form of a dough rolling machine and dough thinning machine facilitates the Dupitos production process. Thus, partners can work more efficiently and effectively. This service provides several benefits both in terms of quality and quantity. It is hoped that the implementation of the service can provide benefits and help both partners to improve the quality and quantity of production.
Keywords: Dupitos, Dusun Petungsewu, equipment assistance
PELATIHAN KEWIRAUSAHAAN PRODUKSI KERAJINAN TANGAN HOME DÉCOR SERTA OPTIMALISASI PEMASARAN PRODUK MELALUI SOSIAL MEDIA DAN MARKET PLACE PADA IBU-IBU PKK KEC. AMPELGADING KAB. MALANG
Authors: Ernawati Widi Dwi , Oktavia Fathimatus Zahro Fazda , Akbar Dharmawan Iqbal , Maula Farisa Nur , Selviana Vuvut 
Published: January 2023

Kaum perempuan dalam masyarakat bisa menjadi satu indikator untuk meningkatkan kesejahteraan dan PKK adalah suatu wadah organisasi perempuan. Ibu-ibu PKK Kecamatan Ampelgading mempunyai latar belakang pendidikan yang sangat bervariasi dengan perekonomian keluarga menengah ke bawah. Dewasa ini, perkembangan teknologi menjadi tantangan tersendiri bagi ibu-ibu. Jika ibu-ibu mampu mengoptimalkan perkembangan teknologi yang dimiliki maka bisa meningkatkan kesejahteraan keluarga mereka. Keterampilan yang dimiliki bisa dikolaborasikan dengan kemandirian mereka untuk dapat mengembangkan berbagai macam peluang usaha. Oleh karena itu, dengan masalah dan potensi yang dimiliki oleh ibu-ibu PKK Ampelgading, pelatihan kewirausahaan produksi kerajinan tangan home décor serta optimalisasi pemasaran produk melalui sosial media dan market place pada ibu-ibu PKK Kecamatan Ampelgading, Kabupaten Malang diharapkan bisa menjadi solusi sehingga dapat meningkatkan taraf kesejahteraan ibu-ibu PKK tersebut.
Fungal keratitis in Iran: Risk factors, clinical features, and mycological profile
Authors: Soleimani Mohammad , Izadi Alireza , Khodavaisy Sadegh , Santos Claudy Oliveira dos , Tehupeiory-Kooreman Marlou C. , Ghazvini Roshanak Daie , Hashemi Seyed Jamal , Mousavi Seyed Amin Ayatollahi , Aala Farzad , Abdorahimi Mahsa , Aminizadeh Mehdi , Abedinifar Zohre , Mahmoudi Shahram , Mohamadi Afsaneh , Rezaie Sara , Verweij Paul E. 
Published: January 2023

IntroductionThis study was intended to investigate the clinical features and predisposing factors of fungal keratitis (FK), as well as molecular identification and antifungal susceptibility of causative agents in Tehran, Iran.MethodsThis cross-sectional study was carried out from April 2019 to May 2021. All fungi isolates were identified using conventional methods and were confirmed by DNA-PCR-based molecular assays. Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) was used to identify yeast species. Minimum inhibitory concentrations (MIC) of eight antifungal agents were assessed according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) microbroth dilution reference method. ResultsFungal etiology was confirmed in 86 (7.23%) of 1189 corneal ulcers. A significant predisposing factor for FK was ocular trauma caused by plant materials. Therapeutic penetrating keratoplasty (PKP) was required in 60.4% of cases. The predominant fungal species isolated was Fusarium spp. (39.5%) followed by Aspergillus spp. (32.5%) and Candida spp. (16.2%).DiscussionThe MIC results indicate that amphotericin B may be appropriate for treating FK caused by Fusarium species. FK caused by Candida spp. can be treated with flucytosine, voriconazole, posaconazole, miconazole, and caspofungin. In developing countries such as Iran, corneal infection due to filamentous fungi is a common cause of corneal damage. In this region, fungal keratitis is observed primarily within the context of agricultural activity and subsequent ocular trauma. Fungal keratitis can be managed better with understanding the ”local“ etiologies and antifungal susceptibility patterns.
Triglyceride-glucose index for the detection of subclinical heart failure with preserved ejection fraction in patients with type 2 diabetes
Authors: Wang Tingting , Xu Jiani , Zhang Hong , Tao Lichan , Huang Xiaolin 
Published: January 2023

ObjectivesThe triglyceride-glucose (TyG) index has been identified as a reliable and simple surrogate of insulin resistance. In this study, we sought to determine the association between TyG index and cardiac function among asymptomatic individuals with type 2 diabetes (T2DM) without history of any cardiovascular disease.Materials and methodsThe cross-sectional study enrolled 180 T2DM patients without cardiac symptoms. Heart failure with preserved ejection fraction (HFpEF) was defined as Heart Failure Association (HFA)-PEFF score ≥ 5 points.ResultsA total of 38 (21.1%) diabetic patients were identified with HFpEF. Compared with the low-TyG group (TyG index &lt;9.47), patients in high-TyG group (TyG index ≥9.47) showed increased risk of metabolic syndrome and diastolic dysfunction (p &lt; 0.05 for each). Furthermore, after adjustment of confounding variables, the TyG index showed positive correlation with risk factors of metabolic syndrome (including BMI, waist circumference, blood pressure, HbA1c, TG, TC, non-HDL-C, and fasting blood glucose, p &lt; 0.05 for each) and parameters of diastolic dysfunction (E/e’ ratio, p &lt; 0.0001) in patients with T2DM. Moreover, Receiver Operating Characteristic curve analysis showed that the TyG index could be better to predict the risk of suspected HFpEF than other indicators (AUC: 0.706, 95% CI: 0.612–0.801). According, on multiple regression analysis, TyG index was independently correlated with the incidence of HFpEF (odds ratio: 0.786, p = 0.0019), indicating that TyG index could be a reliable biomarker to predict the risk of HFpEF.ConclusionThe TyG index showed a positive correlation with the risk of subclinical HFpEF in patients with T2DM, providing a new marker to predict and treat HFpEF in diabetes.
Sepsis as an independent risk factor in atrial fibrillation and cardioembolic stroke
Authors: Leng Yiming , Li Yalan , Wang Jie , Deng Peizhi , Wang Wei , Wu Jingjing , Wang Wenjuan , Weng Chunyan 
Published: January 2023

BackgroundElectrolyte balance is an important factor to sustain the homeostasis of human body environment and in sepsis pathogenesis. Many current cohort-based studies have already revealed that electrolyte disorder may intensify sepsis and induce stroke. However, the corresponding randomized controlled trials did not show that electrolyte disorder in sepsis has a harmful effect on stroke.ObjectivesThe aim of this study was to examine the association of genetically sepsis-derived electrolyte disorder with stroke risk using meta-analysis and Mendelian randomization.ResultsIn four studies (182,980 patients), electrolyte disorders were compared with stroke incidence in patients with sepsis. The pooled odds ratio (OR) of stroke is 1.79 [95% confidence interval (CI): 1.23–3.06; p &lt; 0.05], which shows a significant association between electrolyte disorder and stroke in sepsis patients. Furthermore, in order to evaluate the causal association between stroke risk and sepsis-derived electrolyte disorder, a two-sample Mendelian randomization (MR) study was conducted. The genetic variants extracted from a genome-wide association study (GWAS) of exposure data that are strongly associated with frequently used sepsis were used as instrumental variables (IVs). Based on the IVs’ corresponding effect estimates, we estimated overall stroke risk, cardioembolic stroke risk, and stroke induced by large/small vessels from a GWAS meta-analysis with 10,307 cases and 19,326 controls. As a final step to verify the preliminary MR results, we performed sensitivity analysis using multiple types of Mendelian randomization analysis.ConclusionOur study revealed the association between electrolyte disorder and stroke in sepsis patients, and the correlation between genetic susceptibility to sepsis and increased risk of cardioembolic stroke, hinting that cardiogenic diseases and accompanying electrolyte disorder interference in due course could help sepsis patients get more benefits in stroke prevention.
Therapeutic efficacy of platinum/etoposide regimens in the treatment of advanced poorly differentiated neuroendocrine carcinomas of the lung: A retrospective analysis
Authors: Puliafito Ivana , Chillari Federico , Russo Alessandro , Cantale Ornella , Sciacca Dorotea , Castorina Luigi , Colarossi Cristina , Franchina Tindara , Vitale Maria Paola , Ricciardi Giuseppina Rosaria Rita , Adamo Vincenzo , Esposito Francesca , Giuffrida Dario 
Published: January 2023

BackgroundLung neuroendocrine neoplasms (NENs) are rare malignancies developed from bronchial mucosa. Because of its rarity and complex histopathology, there is limited data on the role of chemotherapy in this subset of tumors. Few studies regarding the treatment of poorly differentiated lung NENs, known as neuroendocrine carcinomas (NECs), are available and many limits are detectable as heterogeneity of tumor samples including different origins and different clinical behaviors, moreover, no evidence of therapeutic advances have been achieved along the last thirty years.MethodWe performed a retrospective analysis of 70 patients affected by poorly differentiated lung NECs: half of patients underwent a first line therapy with a combination of cisplatin plus etoposide; the remaining patients receiving carboplatin instead of cisplatin, plus etoposide. Results: In our analysis, the outcomes of patients treated with either cisplatin or carboplatin schedule are similar in terms of ORR (44% versus 33%), DCR (75% versus 70%), PFS (6.0 versus 5.0 months) and OS (13.0 versus 10 months). Median number of chemotherapy cycles was 4 (range 1-8). The 18% of patients required a dose reduction. Main toxicities reported were hematological (70.5%), gastrointestinal (26.5%) and fatigue (18%).ConclusionSurvival rate in our study suggests that high grade lung NENs are characterized by an aggressive behavior and a poor prognosis, despite the treatment with platinum/etoposide according to available data. Clinical results of present study contribute to strengthen available data on the usefulness of platinum/etoposide regimen in the treatment of poorly differentiated lung NENs
Association between preconception anti-androgen therapy and pregnancy outcomes of patients with PCOS: A prospective cohort study
Authors: Zhang Xiaowei , Miao Huazhang , Zhou Jiahe , Chen Yuan , Ou Yanlan , Song Yue , Peng Xiuhong , Li Yuancheng , Li Li 
Published: January 2023

BackgroundPolycystic ovary syndrome (PCOS) not only increases fertility challenges for women of reproductive age, but also leads to increased complications during pregnancy and even affects the birth weight of newborns. Also, hyperandrogenemia is associated with lower pregnancy rates and lower live birth rates and may even play a role in preterm delivery and pre-eclampsia in patients with PCOS. However, it is still controversial whether PCOS patients are treated with androgen-lowering therapy before pregnancy.ObjectiveTo assess the effect of anti-androgen therapy prior to ovulation induction on maternal and infant pregnancy outcomes in patients with PCOS.MethodsProspective cohort study.ResultsA total of 296 patients with PCOS were enrolled in the study. The prevalence of adverse pregnancy outcomes, and neonatal complications was lower in DRSP(with drospirenone ethinyl estradiol tablets (II) pretreatment) group than in NO-DRSP(without drospirenone ethinyl estradiol tablets (II) pretreatment) groups (DRSP vs. NO-DRSP: adverse pregnancy outcomes, 12.16% vs. 27.03%, P=0.001; neonatal complications, 17.16% vs. 36.67%, P&lt;0.001). No significant difference was found in maternal complications. Further subgroup analysis revealed that PCOS with pretreatment decreased the risk of preterm delivery (2.99% vs. 10.00%; Adjusted RR, 3.80; 95% CI, 1.19-12.13), pregnancy loss (9.46% vs. 18.92%; Adjusted RR, 2.07; 95% CI, 1.08-3.96), low birth weight (0.75% vs 7.50%; Adjusted RR, 12.08; 95% CI, 1.50-97.31), fetal malformations(1.49% vs. 8.33%; Adjusted RR, 5.63; 95% CI, 1.20-26.33).There were no significant differences in the incidence of DM and PIH as pregnancy complications between the two groups (P&gt;0.05).ConclusionOur findings suggest that preconception androgen-lowering therapy in patients with PCOS improves pregnancy outcomes and reduces neonatal complications.
Long noncoding RNA MyD88 functions as a promising diagnostic biomarker in hepatocellular carcinoma
Authors: Wang Zhihuai , Gao Peng , Sun Weijun , Rehman Adeel ur , Jiang Jiakai , Xu Suobao , Xue Cailin , Zhu Chunfu , Qin Xihu 
Published: January 2023

BackgroundHepatocellular carcinoma (HCC) is one of the most frequent malignancies. Alpha-fetoprotein (AFP) has some limitations in diagnosing early HCC. Recently, long noncoding RNAs (lncRNAs) showed great potential as tumor diagnostic biomarkers, and lnc-MyD88 was previously identified as a carcinogen in HCC. Here, we explored its diagnostic value as a plasma biomarker.Materials and methodsQuantitative real-time PCR was adopted to detect lnc-MyD88 expression in plasma samples of 98 HCC patients, 52 liver cirrhosis (LC) patients, and 105 healthy people. The correlation between lnc-MyD88 and clinicopathological factors was analyzed through chi-square test. The receiver operating characteristic (ROC) curve was used to analyze the sensitivity, specificity, Youden index, and area under the curve (AUC) of lnc-MyD88 and AFP alone and in combination for the diagnosis of HCC. The relationship between MyD88 and immune infiltration was analyzed by single sample gene set enrichment analysis (ssGSEA) algorithm.ResultsLnc-MyD88 was highly expressed in plasma samples of HCC and hepatitis B virus (HBV)-associated HCC patients. Lnc-MyD88 had better diagnostic value than AFP in HCC patients using healthy people or LC patients as control (healthy people, AUC: 0.776 vs. 0.725; LC patients, AUC: 0.753 vs. 0.727). The multivariate analysis showed that lnc-MyD88 had great diagnostic value for distinguishing HCC from LC and healthy people. Lnc-MyD88 had no correlation with AFP. Lnc-MyD88 and AFP were independent diagnostic factors for HBV-associated HCC. The AUC, sensitivity, and Youden index of the combined diagnosis of lnc-MyD88 and AFP combined were higher than those of lnc-MyD88 and AFP alone. The ROC curve of lnc-MyD88 for the diagnosis of AFP-negative HCC was plotted with a sensitivity of 80.95%, a specificity of 79.59%, and an AUC value of 0.812 using healthy people as control. The ROC curve also presented its great diagnostic value using LC patients as control (sensitivity: 76.19%, specificity: 69.05%, AUC value: 0.769). Lnc-MyD88 expression was correlated with microvascular invasion in HBV-associated HCC patients. MyD88 was positively correlated with infiltrating immune cells and immune-related genes.ConclusionThe high expression of plasma lnc-MyD88 in HCC is distinct and could be utilized as a promising diagnostic biomarker. Lnc-MyD88 had great diagnostic value for HBV-associated HCC and AFP-negative HCC, and it had higher efficacy in combination with AFP.
Preventing stillbirth from obstructed labor: A sensorized, low-cost device to train in safer operative birth
Authors: Jaufuraully Shireen , Salvadores Fernandez Carmen , Bagchi Biswajoy , Gupta Priya , Desjardins Adrien , Siassakos Dimitrios , David Anna L. , Tiwari Manish K. 
Published: January 2023

Background98% of stillbirths occur in low- and middle- income countries. Obstructed labor is a common cause for both neonatal and maternal mortality, with a lack of skilled birth attendants one of the main reasons for the reduction in operative vaginal birth, especially in low- and middle- income countries. We introduce a low cost, sensorized, wearable device for digital vaginal examination to facilitate accurate assessment of fetal position and force applied to the fetal head, to aid training in safe operative vaginal birth.MethodsThe device consists of flexible pressure/force sensors mounted onto the fingertips of a surgical glove. Phantoms of the neonatal head were developed to replicate sutures. An Obstetrician tested the device on the phantoms by performing a mock vaginal examination at full dilatation. Data was recorded and signals interpreted. Software was developed so that the glove can be used with a simple smartphone app. A patient and public involvement panel was consulted on the glove design and functionality.ResultsThe sensors achieved a 20 Newton force range and a 0.1 Newton sensitivity, leading to 100% accuracy in detecting fetal sutures, including when different degrees of molding or caput were present. They also detected sutures and force applied with a second sterile surgical glove on top. The software developed allowed a force threshold to be set, alerting the clinician when excessive force is applied. Patient and public involvement panels welcomed the device with great enthusiasm. Feedback indicated that women would accept, and prefer, clinicians to use the device if it could improve safety and reduce the number of vaginal examinations required.ConclusionUnder phantom conditions to simulate the fetal head in labor, the novel sensorized glove can accurately determine fetal sutures and provide real-time force readings, to support safer clinical training and practice in operative birth. The glove is low cost (approximately 1 USD). Software is being developed so fetal position and force readings can be displayed on a mobile phone. Although substantial steps in clinical translation are required, the glove has the potential to support efforts to reduce the number of stillbirths and maternal deaths secondary to obstructed labor in low- and -middle income countries.
Determinants of maternal satisfaction with focused antenatal care services rendered at public health facilities in the West Shewa Zone, Central Ethiopia: A multicentre cross-sectional study
Authors: Bekele Gemechu Gelan , Seifu Benyam , Roga Ephrem Yohannes 
Published: January 2023

BackgroundEvery woman has the right to receive quality care during pregnancy. It is proven that antenatal care (ANC) reduces maternal and perinatal morbidity and mortality. The government of Ethiopia is also making intense efforts to increase the coverage of ANC. However, among pregnant women, the levels of satisfaction with the care provided are overlooked, as the percentage of women who complete all ANC visits is below 50. Therefore, this study aims to assess maternal satisfaction with ANC services rendered at public health facilities in the West Shewa Zone, Ethiopia.MethodsA facility-based cross-sectional study was conducted among women who were receiving ANC in public health facilities in Central Ethiopia between September 1 and October 15, 2021. A total of 411 women were selected using the systematic random sampling method. The questionnaire was pretested and the data were collected electronically using CSEntry. The collected data were exported to SPSS version 26. The characteristics of the study participants were described using frequency and percentage. Bivariate and multivariate logistic regression were used to identify the factors associated with maternal satisfaction with focused ANC service.ResultThis study revealed that 46.7% [95% confidence interval (CI) (41.7%–51.6%)] of women were satisfied with ANC service. Factors such as the quality of the health institution [adjusted odd ratio (AOR) = 5.10, (95% CI: 3.33–7.75)], place of residence [AOR = 2.38, (95% CI: 1.21–4.70)], history of abortion [AOR = 0.19, (95% CI: 0.07–0.49)], and previous mode of delivery [AOR = 0.30, (95% CI: 0.15–0.60)] were significantly associated with women's satisfaction with focused ANC service.ConclusionMore than half of pregnant women who received ANC were dissatisfied with the service they received. This should be a cause for concern, as the level of satisfaction is lower than that of the findings of previous studies conducted in Ethiopia. Institutional variables, interactions with patients, and previous experiences of pregnant women have an impact on the level of satisfaction. Due attention should be paid to primary health and communication of health professionals with pregnant women to improve the levels of satisfaction with focused ANC service.