bluuebunny/crossref_metadata_2025_split huggingface dataset:
An observational study of endometrial vascularity in implantation
Authors: Gambhire Bhadugale Harsha , Tekawade Umesh , Shelar Suvarna , Herlekar Suhas 
Published: July 2023

Background: According to Ayurveda, Ambu is one of the four essential factors of Garbhasambhav Samugri for formation and development of the embryo. The word Ambu means nutrients essential for formation and growth of embryo which it receives from mother. According to modern science, during implantation, embryo receives its nutrients from endometrium. Though some women have normal endometrial thickness, normal endometrial pattern, normal endometrial morphology, still they are unable to get impregnated. During peri-implantation period of menstrual cycle, endometrial vascularity has major role in implantation of fertilised egg and also further growth of foetus. Objectives: The objective of this study is to evaluate implantation rates in women having endometrial vascularity upto V1, V2, V3, V4 zones. Material & Methods: Anonymous data of endometrial vascularity by transvaginal colour doppler ultrasound examination done, on the day of rupture of follicle of menstrual cycle, on 160 women, willing to conceive, has been collected from gynaecologist. And also, her status whether she was implanted or not implanted was collected from the gynaecologist. Data about her pregnancy status upto 20 weeks were collected. From this collected data, results regarding endometrial vascularity were derived. Results: Implantation rate in cases having vascularity upto V1 zone, upto V2 zone, upto V3 zone, upto V4 zone were 0 %, 8.33 %, 25 %, 30.5% respectively. Conclusion: Implantation rate is greater in cases having vascularity upto V3 and V4 zone than V1 & V2 zone. Endometrial vascularity is an important factor for implantation of fertilized egg and also for further growth of embryo.
Validation of hospital environmental disinfection efficiency of herbal fumigants
Authors: Tavhare Swagata Dilip , Lakhani Karan 
Published: July 2023

Background: Healthcare associated infections includes infestation by bacteria, viruses and fungi. As per WHO estimates, approximately 15% of all hospitalized patients suffer from these nosocomial infections caused by these micro-organisms. Outbreaks of such infections increases the use of antibiotics, vitamins and immonomodulator medicines. During ancient times, to prevent spread of infections; fumigation with herbs was a practice and it is still seen continued. Material & methods: Good quality herbal fumigants like Guggulu gum-resin, turmeric powder, spikenard rhizome, white mustard fruits, caraway fruits, camphor resins and cow’s ghee were used for fumigation of various hospital rooms like out-patient department room, dental clinic, gynecological procedure room, physiotherapy and operation theatre of Community Healthcare Center, Sarsa. Swabs from these units were tested for bacterial and fungal load before and after experiment by using culture media’s like nutrient broth and potato dextrose agar respectively. Results: The bacteria culture reported organisms namely Bacilus subtilis, Bacilus megaterium, Staphylococcus aureus, Micrococcus luteus and fungi like Aspergillus niger, mucor and rhizophus. After 30 minutes of fumigation procedure, significant reduction in bacterial colonies was found in gynecological procedure room, dental clinic, OPD and physiotherapy room while statistically non-significant results were observed in operation theatre. Two hours after fumigation, statistically significant result was observed in bacterial count in all studied units except operation theatre while fungal colonies reduction was achieved in all studied units. Conclusion: Fumigation shall be encouraged in hospital units like out patients department, wards and minor procedure rooms but may not be perfectly suitable for operative theatres always. The study encourages daily herbal fumigation of home and surroundings for hygienic and pleasant environment.
An Insilico Computational Screening of Siddha Formulation Kalingathy Thailam against Cyp- 17α-Hydroxylase in PCOS
Authors: G Dhivya , K Bharathy , T Lakshmi Kantham , R Meenakumari 
Published: July 2023

Background: PCOS is characterized by ovulatory failure, hirsutism, obesity, glucose intolerance, resistance to insulin, dyslipidemia and infertility. Siddha system of medicine has a worthwhile therapeutic effect in treating PCOS. The bioactive compounds of Kalingathy Thailam mentioned in Siddha literature was selected for evaluating their ability to inhibit CYP- 17α-hydroxylase. Objective: The study is aimed to perform the In Silico computational screening of the formulation Kalingathy Thailam against the target enzyme CYP-17 α -hydroxylase in PCOS. Methods: Autodock program was used against the target enzyme CYP-17 α -hydroxylase for the phytocomponents such as Sinapic acid, Cucurbitacin B of Citrullus colocynthis (L. ) Schrader, Aromadendrene, Linolenic acid of Melia dubia Linn. , Onionin A, Protocatechuic acid of Allium cepa Linn. , Ascorbic acid, Limonene of Citrus limon (L. )Burm. f. , Ricinine of Ricinus communis Linn. Results: A total of 9 components were screened, out of these Protocatechuic acid, Ascorbic acid, Linolenic acid and Cucurbitacin B reveals maximum of 2 to 3 interactions accounting for 75-100% binding efficacy with the core active amino acid residues present on the target enzyme CYP- 17α-hydroxylase. Conclusion: Based on the results of the computational analysis it was concluded that the bio-active compounds present in the herbal ingredients possess significant binding against the target enzyme CYP-17α-hydroxylase by interacting with active amino acids. Hence these phytocomponents which inhibit the target enzyme may act as a potential therapeutic agent for management of PCOD.
UJI PEMAHAMAN KONSEP MAHASISWA PENDIDIKAN BIOLOGI PADA MATERI FISIKA DASAR DENGAN SOAL KONTEKSTUAL DAN NONKONTEKSTUAL
Authors: Fatimah Fita , Ulfa Noviana Mariatul 
Published: July 2023

Fisika berasal dari bahasa Yunani yang berarti “alam”. Fokus dari ilmu fisika adalah mempelajari tentang sifat dan fenomena alam atau gejala alam dan seluruh interaksi yang terjadi didalamnya. Fisika berperan dalam berbagai ilmu pengetahuan lain, salah satunya biologi (biofisika). Hasil wawancara awal menunjukkan bahwa banyak yang masih menganggap fisika itu sulit dan tidak ada kaitannya dengan biologi. Tujuan penelitian ini adalah untuk mengetahui tingkat pemahaman konsep mahasiswa Program Studi Pendidikan Biologi pada materi Fisika Dasar yang disajikan dalam soal versi kontekstual dan nonkontekstual serta mengetahui tanggapan mereka terhadap terhadap asesmen pemahaman konsep fisika soal “kontekstual” dan “nonkontekstual”. Instrumen yang digunakan dalam penelitian adalah instrumen berupa soal-soal pemahaman konsep fisika yang disusun dalam versi kontekstual dan nonkontekstual serta instrumen angket untuk menjaring tanggapan. Hasil penelitian menunjukkan bahwa : 1) Secara umum pemahaman konsep mahasiswa program studi pendidikan biologi pada materi fisika dasar masih rendah baik dalam soal-soal versi kontekstual maupun nonkontekstual; 2) Kemampuan pemahaman konsep mahasiswa program studi pendidikan biologi pada materi fisika dasar lebih tinggi untuk soal versi kontekstual dibandingkan soal versi nonkontekstual; 3) penyajian soal-soal pemahaman konsep dalam versi “kontekstual” dapat mengubah persepsi mahasiswa tentang fisika yang awalnya merupakan mata kuliah yang tidak berkaitan dengan biologi menjadi fisika sebagai mata kuliah yang diperlukan dalam biologi. Hal ini menjadi motivasi bagi mahasiswa dalam mempelajari fisika untuk meningkatkan penguasaan mereka terhadap pengetahuan atau fenomena yang dipelajari dalam biologi.
Strategy Generation for Risk Minimization of Renewable Energy Technology Investments in Hospitals with SF TOP-DEMATEL Methodology
Authors: Dincer Hasan , Eti Serkan , Yuksel Serhat , Gokalp Yasar , Celebi Busra 
Published: July 2023

Effective risk management plays an important role to improve renewable energy technology investments. Because of this issue, necessary actions must be implemented to effectively manage these risks. However, having high costs is the biggest disadvantage of the implementation of these actions. Therefore, it is not financially possible to implement different strategies together. In other words, it is necessary to identify the most important of these strategies. Accordingly, the purpose of this study is to make a priority evaluation for the risk strategies related to renewable energy technologies in hospitals. For this purpose, a new model is generated with spherical fuzzy (SF) TOP-DEMATEL technique. In this process, significant indicators are defined based on literature evaluations. In the next process, the weights of these indicators are calculated. The main contribution of this study is that a new technique is proposed by the name of TOP-DEMATEL. In this scope, the final steps of TOPSIS are integrated to the analysis process of DEMATEL to overcome criticisms for classical DEMATEL technique. Moreover, a priority evaluation is carried out to understand the most critical risk management strategies in renewable energy technology investments. With the help of this analysis, it can be much easier to take risk management actions without having financial difficulties. It is determined that the weighting results of the criteria are quite similar for different t values. This situation identifies that the proposed model provides coherent and reliable results. It is concluded that government support is the most important strategy in this context. Additionally, technological improvements also play a crucial role for this situation. It is strongly recommended that governments should establish appropriate legal and regulatory frameworks to promote renewable energy projects. These frameworks can facilitate the financing and licensing of projects and offer economic incentives such as tax incentives and subsidies.

Received: 31 May 2023 | Revised: 22 June 2023 | Accepted: 9 July 2023

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
New-onset hypertension is not associated with systemic changes in inflammatory cytokine levels
Authors: Walczewska Jolanta , Dzieża Anna , Siga Olga , Wizner Barbara , Mikołajczyk Tomasz P , Sulicka-Grodzicka Joanna , Grodzicki Tomasz 
Published: July 2023

IntroductionRecent studies have suggested that hypertension develop�ment may be associated with an altered immune system. However, there is a paucity of data evaluating the association between blood pressure values and inflammatory markers in patients with new-onset hypertension.Material and methodsWe evaluated 61 subjects, including 24 healthy indi�viduals and 37 newly diagnosed hypertensive patients (aged 45 ±9.6 vs. 43.8 ±11.9 years; SBP_24hours 114 ±7.1 vs. 134.2 ±9.5 mm Hg; DBP_24hours 71.2 ±4.7 vs. 85.8 ±9.3 mm Hg, respectively) without prior antihypertensive treatment. The diagnosis of hypertension was based on 24-hour ambulatory blood pressure monitoring (ABPM). We analysed the association between
blood pressure values and levels of individual inflammatory markers (ITAC, GM-CSF, fractalkine, IFN-g, IL-10, MIP-3a, IL-12, IL-13, IL-17A, IL-1b, IL-2, IL-21, IL-23, IL-5, IL-6, IL-7, IL-8, MIP-1a, MIP-1b, TNF-a, and IL-15) sepa�rately, as well as in clusters of inflammatory mediators (factor 1 – proin�flammatory: IL-1β, IL2, IL-6, IL-7, IL-12, IL-6, IL-21, TNF-α, IFN-γ; and factor 2 – anti-inflammatory: IL-13, IL-5).ResultsOur study did not show any differences in concentrations of inflam�matory markers between patients and controls. Plasma levels of inflamma�tory markers were not associated with 24-hour ambulatory blood pressure values in patients with new-onset hypertension.ConclusionsPatients with new-onset hypertension did not differ from healthy subjects regarding the levels of plasma inflammatory markers. Our findings demonstrate the need for larger, more comprehensive studies on this topic to further elucidate the relationship between hypertension and inflammation.
INTRODUÇÃO À TEORIA DA RELATIVIDADE ESPECIAL MEDIADO POR JOGO DIDÁTICO
Authors: Meneses Kelly Krystinne Silva de , Conceição Maria Josielma Santos da , Vieira Geovane dos Santos , Freitas Felipe Alexandre Medeiros de 
Published: July 2023

Este artigo ressalta a importância da utilização de jogos educativos como recurso de apoio didático no processo ensino aprendizagem, e tem como objetivo a aplicação de um jogo previamente selecionado a ser utilizado como recurso didático nas turmas do 3° do ensino médio para se trabalhar os conceitos fundamentais que norteiam a Teoria da Relatividade Especial. Com características que versam sobre a ludicidade, apresentada de forma bem estruturada, o docente realizará uma avaliação diagnóstica qualitativa junto aos discentes, no intuito de caracterizar os conhecimentos prévios relevantes para se aprender essa teoria, relacionados aos conteúdos de Mecânica, Termologia, Óptica, Ondulatória e Eletromagnetismo. Para uma posterior elaboração das questões que serão abordadas na adaptação do jogo tradicionalmente conhecido como ROLETA. Com isso, espera-se que após a aplicação do jogo, nas turmas do 3° ano do ensino médio, obtenha-se como resultado despertar nos alunos o interesse pela Teoria da Relatividade, bem como contribuir para a ampliação da discussão teórica sobre a aplicação de jogos educativos durante o referido processo.
Atmospheric oxidation of new “green” solvents – Part 2: methyl pivalate and pinacolone
Authors: Mapelli Caterina , Donnelly James K. , Hogan Úna E. , Rickard Andrew R. , Robinson Abbie T. , Byrne Fergal , McElroy Con Rob , Curchod Basile F. E. , Hollas Daniel , Dillon Terry J. 
Published: July 2023

Abstract. Lab-based experimental and computational methods were used to study the atmospheric degradation of two promising “green” solvents: pinacolone, (CH3)3CC(O)CH3, and methyl pivalate, (CH3)3CC(O)OCH3. Pulsed laser photolysis coupled to pulsed laser-induced fluorescence was used to determine absolute rate coefficients (in 10−12 cm3 molec.−1 s−1) of k1(297 K) = (1.2 ± 0.2) for OH + (CH3)3CC(O)CH3 (Reaction R1) and k2(297 K) = (1.3 ± 0.2) for OH + (CH3)3CC(O)OCH3 (Reaction R2), in good agreement with one previous experimental study. Rate coefficients for both reactions were found to increase at elevated temperature, with k1(T) adequately described by k1(297–485 K) = 2.1 × 10−12 exp(-200/T) cm3 molec.−1 s−1. k2(T) exhibited more complex behaviour, with a local minimum at around 300 K. In the course of this work, k3(295–450 K) was obtained for the well-characterised reaction OH + C2H5OH (ethanol; Reaction R3), in satisfactory agreement with the evaluated literature. UV–Vis spectroscopy experiments and computational calculations were used to explore cross-sections for (CH3)3CC(O)CH3 photolysis (Reaction R4), while (CH3)3CC(O)OCH3 showed no sign of absorption over the wavelengths of interest. Absorption cross-sections for (CH3)3CC(O)CH3, σ4(λ), in the actinic region were larger, and the maximum was red-shifted compared to estimates (methyl ethyl ketone (MEK) values) used in current state-of-science models. As a consequence, we note that photolysis (Reaction R4) is likely the dominant pathway for removal of (CH3)3CC(O)CH3 from the troposphere. Nonetheless, large uncertainties remain as quantum yields φ4(λ) remain unmeasured. Lifetime estimates based upon Reactions (R1) and (R4) span the range 2–9 d and are consequently associated with a poorly constrained estimated photochemical ozone creation potential (POCPE). In accord with previous studies, (CH3)3CC(O)OCH3 did not absorb in the actinic region, allowing for straightforward calculation of an atmospheric lifetime of ≈ 9 d and a small POCPE ≈ 11.
Los colores como referentes culturales e idiosincrásicos: un análisis traductológico y comparativo español-italiano
Authors: Trovato Giuseppe 
Published: July 2023

Este artículo tiene como objetivo presentar el análisis de una serie de unidades léxicas, a veces con carácter idiomático del español, que tienen en su núcleo los colores, con miras a comprobar si existe una equivalencia total, parcial o nula entre dos lenguas afines como son el español y el italiano en lo referente a los colores considerados como referentes culturales e idiosincrásicos.
Aparte de estudiar si se usan los mismos colores en las dos lenguas para expresar los mismos valores y matices semánticos y metafóricos, estudiaremos si en el acervo fraseológico del italiano se opta por un color o bien por otro elemento lingüístico-cultural. En este sentido, barajaremos diferentes posibilidades y opciones de traducción que proceden de la actividad de traducción profesional.
En los resultados del rastreo traductológico, realizaremos una labor de sistematización del uso de los colores en español e italiano en el ámbito de la fraseología contrastiva.
The Pivotal Role of Melquiades in The Magical Realism of One Hundred Years of Solitude
Authors: John Muhammad Ali Khan Clement , Saeed Omera , Kamran Muhammad , Ahmed Tanveer 
Published: July 2023

Melquiades is a complex and enigmatic character in One Hundred Years of Solitude. His suspension between fact and fantasy marks him as the signature contributor to the magical realism for which the novel is widely acclaimed. This study aims to examine the nature of his role in the interaction between reality and unreality which seems to portend the fortunes of the Buendia family and the fate of their town Macondo. Since his character is marked by a recurring ebb and flow between verity and illusion, it is expedient to deploy the lens of a theory or theories which deal with the symbiotic relationship between these two polar opposites which, in their various perspectives and permutations, coalesce to form the unique depiction of magical realism in this novel. To this purpose, two theoretical works are utilized in this study. The first is Magical Realism: Theory, History, Community (1995) by Roh, F. et. al., and the second is A Short Melquiades is a complex and enigmatic character in One Hundred Years of Solitude. His suspension between fact and fantasy marks him as the signature contributor to the magical realism for which the novel is widely acclaimed. This study aims to examine the nature of his role in the interaction between reality and unreality which seems to portend the fortunes of the Buendia family and the fate of their town Macondo. Since his character is marked by a recurring ebb and flow between verity and illusion, it is expedient to deploy the lens of a theory or theories which deal with the symbiotic relationship between these two polar opposites which, in their various perspectives and permutations, coalesce to form the unique depiction of magical realism in this novel. To this purpose, two theoretical works are utilized in this study. The first is Magical Realism: Theory, History, Community (1995) by Roh, F. et. al., and the second is A Short History of Myth (2000) by Armstrong, K. The conclusion reached is that Melquiades is to be perceived, not as a human character, but as a metaphorical representation of various abstract values as are identified and discussed in this study.
Aktivitas Ekstrak Etanol Daun Akar Kucing (Acalypha indica L.) Sebagai Pengawet Alami Pada Buah Tomat (Lycopersium esculentum Mill.)
Authors: Solichah Ayu Ina , Sawal Rizky Ardian Hartanto , Auliya Fitri 
Published: July 2023

Bahan pengawet pada makanan adalah hal yang biasa dilakukan untuk memperpanjang masa penyimpanan makanan tersebut. Dampak buruk untuk penggunaan bahan pengawet yang berasal dari bahan kimia menyebabkan pencemaran lingkungan dan gangguan kesehatan. Konsumsi bahan pengawet kimia dalam jangka waktu yang panjang akan menyebabkan penyakit kanker. Bahan pengawet alami dibutuhkan untuk mengurangi dampak buruk tersebut. Salah satu tanaman yang dapat digunakan sebagai pengawet alami yaitu daun akar kucing (Acalypha indica L. Penelitian ini bertujuan untuk menentukan aktifitas dan konsentrasi yang efektif dari ekstrak daun akar kucing sebagai pengawet alami pada buah tomat serta mengidentifikasi kandungan fitokimia di dalamnya. Pengujian aktivitas daun akar kucing sebagai pengawet alami terhadap buah tomat dilakukan secara organoleptis. Sedangkan identifikasi kandungan fitokimia dilakukan secara reaksi tabung. Berdasarkan hasil pengamatan organoleptis menunjukkan bahwa ekstrak daun akar kucing efektif sebagai pengawet alami pada konsentrasi 8% dengan lama waktu pengawetan buah tomat adalah 20 hari. Hasil uji reaksi tabung menunjukkan bahwa ekstrak daun akar kucing mengandung senyawa alkaloid, flavonoid, saponin, tanin dan terpenoid.
IDENTIFIKASI MANGIFERIN DAN UJI AKTIVITAS PENGKELAT BESI PADA EKSTRAK DAUN MANGGA (Mangifera indica L.)
Authors: KRISTYANTI YULIA , Lutsina Novi Winda , More Evanisia 
Published: July 2023

Kelainan darah yang disebabkan oleh sintesis globin yang tidak seimbang sehingga mengakibatkan kerusakan hemoglobin dan diturunkan secara resesif, penanganan dilakukan dengan tranfusi darah secara teratur. Tranfusi darah berulang dalam jangka waktu yang lama menyebabkan akumulasi besi dalam tubuh. Tujuan penelitian ini adalah untuk mengetahui kandungan mangiferin dan efektivitas ekstrak daun M. indica L sebagai pengkelat besi secara in vitro.
Ekstrak daun M. indica L diperoleh dengan metode maserasi dengan pelarut etanol 96%. Pengujian kandungan mangiferin dengan metode KLT dan penelitian efektifitas pengkelat besi secara invitro menggunakan metode Ferrous Ion Chelating (FIC), prinsip metode adalah mengukur kemampuan suatu senyawa untuk bersaing dengan ferozine dalam mengkelat logam besi.
Identifikasi KLT menunjukan terdapat kandungan mangiferin pada ekstrak daun M indica L, oleh adanya kesamaan warna bercak dan Rf pada ekstrak dan mangiferin, dengan mengunakan tiga jenis fase gerak yaitu n-heksan : etil asetat:air (6:3:1) dengan nilai Rf 0,1, etil asetat : asam format : air (8:2:1) dengan nilai Rf 0,34 dan metanol : kloroform : air (7:2:1) dengan nilai Rf, 0,8. Hasil pengujian kemampuan mengkelat logam ekstrak etanol daun M. indica L mempunyai efek sebagai pengkelat besi secara in vitro dengan metode FIC. Semakin tinggi konsentrasi maka persentase pengkelat besi semakin tinggi. Ekstrak pada konsentrasi 1, 10 ,20 ,30 dan 40 µg/ml berturut-turut mempunyai persentasi pengkelat besi 6,44 %, 29,87 %, 58,85 %, 75,74 % dan 92,99 %, untuk nilai (IC50) nya adalah 18,73 µg/ml.
PENGARUH PAJAK DAERAH DAN PENDAPATAN PERKAPITA TERHADAP PENDAPATAN ASLI DAERAH DENGAN JUMLAH PENDUDUK SEBAGAI VARIABEL MODERASI SEBELUM DAN MASA PANDEMI COVID-19
Authors: Jaeni Jaeni , Nurcahyani Saktiyana 
Published: July 2023

Penelitian ini bertujuan untuk menganalisis secara simultan dan parsial pengaruh pajak daerah dan pendapatan perkapita terhadap pendapatan asli daerah kabupaten/kota Provinsi Jawa Tengah periode tahun 2018-2021 dengan variabel moderasi yaitu jumlah penduduk. Jenis data yang digunakan yaitu data kuantitatif. Data yang digunakan yaitu data sekunder yang yang diperoleh dari BPS Jawa Tengah. Dari hasil penelitian dapat kesimpulan seluruh variabel independen yaitu pajak daerah dan pendapatan perkapita secara simultan berpengaruh terhadap terhadap pendapatan asli daerah secara parsial pajak daerah berpengaruh positif terhadap pendapatan asli daerah baik sebelum maupun setelah covid-19, pendapatan perkapita berpengaruh positif terhadap pendapatan asli daerah sebelum covid-19 dan berpengruh negatif tidak signifikan setelah covid-19. Jumlah penduduk mampu memoderasi hubungan pajak daerah terhadap pendapatan asli daerah sebelum covid-19 dan jumlah penduduk tidak memoderasi pendapataan perkapita terhadap pendapatan asli daerah setelah covid-19.
Kata kunci: Pajak daerah, PAD, Jumlah Penduduk