bluuebunny/crossref_metadata_2025_split huggingface dataset:
Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new management algorithm
Authors: van Geel Nanja , Speeckaert Reinhart , Taïeb Alain , Ezzedine Khaled , Lim Henry W. , Pandya Amit G. , Passeron Thierry , Wolkerstorfer Albert , Abdallah Marwa , Alomar Augustin , Bae Jung Min , Bekkenk Marcel , Benzekri Laila , Böhm Markus , Eleftheriadou Viktoria , Esmat Samia , Ghia Deepti , Goh Boon Kee , Grimes Pearl , Gupta Somesh , Hamzavi Iltefat H. , Harris John E. , Oh Sang Ho , Huggins Richard , Katayama Ichiro , Lan Eric , Lee Ai‐Young , Leone Giovanni , Le Poole Caroline , Lui Harvey , Maquignon Nicolle , Meurant Jean Marie , Monteiro Paul , Oiso Naoki , Parsad Davinder , Pliszewski Georg , Raboobee Noufal , Rodrigues Michelle , Rosmarin David , Suzuki Tamio , Tanemura Atsushi , Thng Steven , Xiang Flora , Zhou Youwen , Picardo Mauro , Seneschal Julien 
Published: September 2023

AbstractBackgroundThe treatment of vitiligo can be challenging and depends on several factors such as the subtype, disease activity, vitiligo extent, and treatment goals. Vitiligo usually requires a long‐term approach. To improve the management of vitiligo worldwide, a clear and up‐to‐date guide based on international consensus with uniform stepwise recommendations is needed.ObjectivesTo reach an international consensus on the nomenclature and to develop a management algorithm for the diagnosis, assessment, and treatment of vitiligo.MethodsIn this consensus statement, a consortium of 42 international vitiligo experts and four patient representatives participated in online and live meetings to develop a consensus management strategy for vitiligo. At least two vitiligo experts summarized the evidence of topics included in the algorithms. A survey was utilized to resolve remaining issues among a core group of eight experts. Subsequently, the unanimous recommendations were finalized and validated based on further input from the entire group during two live meetings.ResultsThe algorithms highlight the importance of shared decision‐making. Dermatologists are encouraged to provide patients with detailed explanations of the prognosis and expected therapeutic outcomes based on clinical examination. The treatment goal should be discussed and clearly emphasized to patients given the different approaches for disease stabilization and repigmentation. The evaluation of disease activity remains a cornerstone in the tailor‐made approach to vitiligo patients.ConclusionsThese new treatment algorithms are intended to guide clinical decision‐making in clinical practice. Promising novel therapies for vitiligo are on the horizon, further highlighting the need for reliable outcome measurement instruments and greater emphasis on shared decision‐making.
Pseudovampyrella gen. nov.: A genus of Vampyrella‐like protoplast extractors finds its place in the Leptophryidae
Authors: Suthaus Andreas , Hess Sebastian 
Published: September 2023

AbstractVampyrellid amoebae are predatory protists, which consume a variety of eukaryotic prey and inhabit freshwater, marine and terrestrial ecosystems. Although they have been known for almost 150 years, much of their diversity lacks an in‐depth characterization. To date, environmental sequencing data hint at several uncharacterized lineages, to which no phenotype is associated. Furthermore, there are numerous historically described species without any molecular information. This study reports on two new vampyrellid strains from moorlands, which extract the protoplasts of Closterium species (Zygnematophyceae). Our data on morphology, prey range specificity and feeding strategy reveal that the studied vampyrellids are very similar to the historically described Vampyrella closterii. However, phylogenetic analyses demonstrate that the two strains do not belong to the genus Vampyrella and, instead, form a distinct clade in the family Leptophryidae. Hence, we introduce a new genus of algivorous protoplast extractors, Pseudovampyrella gen. nov., with the species P. closterii (= V. closterii) and P. minor. Our findings indicate that the genetic diversity of morphologically described vampyrellid species might be hugely underrated.
The pathway of Edwardsiella piscicida infecting Lateolabrax maculatus via the immersion bath
Authors: Hu Jianmei , Wang Baotun , Ma Zhuang , Feng Juan , Jiang Biao , Su Youlu 
Published: September 2023

AbstractEdwardsiella piscicida, an infectious bacterium, causes great economic losses to the aquaculture industry. Immersion bath which is the closest way to how the fish infect bacterial pathogens in the natural environment is an effective route of artificial infection. In this study, the dynamic process of E. piscicida infection, in the spotted sea bass (Lateolabrax maculatus) was evaluated via the immersion bath. The results showed that soaking the spotted sea bass with 3 × 106 CFU mL−1 E. piscicida for 30 min could artificially induce edwardsiellosis. The higher culture temperature (28.5 ± 0.5°C) or the longer bath time (30 min) would lead to higher mortality of fish. E.piscicida first invaded the gill, then entered the blood circulation to infect the spleen and kidney, where it is colonized, and gradually multiplied in the liver and brain. Meanwhile, the fluorescence in situ hybridization showed that the localization of E. piscicida in the gill and foregut after the immersion challenge proceeded from the exterior to the interior. The invasion of pathogens triggers the immune response of fish and causes tissue damage to the host. The quantitative real‐time PCR results displayed an increase in the relative expression level of immune genes (NK‐lysin, LZM, IgM and IgD). Otherwise, the most notable histopathological changes of the infected spotted sea bass were multifocal necrosis. Findings in this study broaden our understanding of the infection conditions of E. piscicida and its pathogenicity to the spotted sea bass.
Study on the current status of exposure to pathogenic microorganisms and consumers' interest in milk tea
Authors: Tran Thanh , Nguyen Nhut Thanh , Thanh Tu Nguyen Thi , Tran Hoang Cam Tu , Phuong Tran Thi Bich , Duong Do Vinh , Banerjee Sreejita , Ho Loc Huu 
Published: September 2023

AbstractThe assurance of food safety is paramount, especially concerning ready‐to‐drink products like milk tea. This research sought to gauge the safety perceptions of both student and office worker demographics towards this beverage using a combination of direct and online surveys. The data reveals that 84.6% of respondents express significant concerns about hygiene and safety standards within milk tea consumption. A substantial portion of these consumers indicates a willingness to expend between 2‐4 USD per serving. Alarmingly, analyses of several popular milk tea brands have identified considerable concentrations of pathogenic microorganisms: Coliform counts were observed at 108, E. Coli at 1010, Pseudomonas at 108, and Salmonella at 104 (CFU/mL). A primary suspected avenue of this microbiological contamination appears to be ice, which exhibits levels exceeding nationally stipulated safety thresholds.
Gastrointestinal: Weight gain increases the risk of metachronous advanced colorectal neoplasm observed in post‐polypectomy surveillance colonoscopy
Authors: Lee Sinwon , Do Yoon Suh , Lee Hyo Jeong , Kim Gwang‐Un , Park Hye Won , Chang Hye‐Sook , Choe Jaewon , Byeon Jeong‐Sik , Lee Ji Young 
Published: September 2023

AbstractBackground and AimAlthough obesity is a known risk factor for colorectal neoplasms, the correlation between weight change and colorectal neoplasm is unclear. Thus, we aim to evaluate the association between weight change and advanced colorectal neoplasm (ACRN) recurrence during post‐polypectomy surveillance colonoscopy.MethodsThis retrospective cohort study included 7473 participants diagnosed with colorectal neoplasms between 2003 and 2010 who subsequently underwent surveillance colonoscopies until 2020. We analyzed the association between the risk of metachronous ACRN and weight change, defining stable weight as a weight change of <3% and weight gain as a weight increase of ≥3% from baseline during the follow‐up period.ResultsDuring a median 8.5 years of follow‐up, 619 participants (8.3%) developed ACRN. Weight gain was reported as an independent risk factor for metachronous ACRN in a time‐dependent Cox analysis. A weight gain of 3–6% and ≥6% had adjusted hazard ratios (AHRs) of 1.48 (95% confidence interval [CI]: 1.19–1.84) and 2.14 (95% CI: 1.71–2.69), respectively. Participants aged 30–49 and 50–75 years with weight gain of ≥6% showed AHRs of 2.88 (95% CI: 1.96–4.21) and 1.90 (95% CI: 1.43–2.51), respectively. In men and women, weight gain of ≥3% was significantly correlated with metachronous ACRN.ConclusionsWeight gain is associated with an increased risk of metachronous ACRN. Furthermore, weight gain is associated with the recurrence of ACRN in both men and women regardless of age.
Frontier politics at the world's end
Authors: Ogden Laura A. 
Published: September 2023

AbstractThe “world's end” or “el fin del mundo” is a very common representational figure used to describe the Fuegian Archipelago of South America. There are world's end hostels, coffee table books, and scientific expeditions, for example, and the phrase is widely used to describe the region's landscape and geography, Indigenous peoples, biota, and to signal precarity along several registers. In this article, I examine the world's end through the lens of the frontier, specifically focusing on how colonial imaginaries of Fuegian peoples as “lost” or lost to history are foundational to the region's territorial projects, including conservation efforts. Research for this paper stems from ethnographic fieldwork in the Fuegian Archipelago, between 2011 and 2018, as well as archival research on colonial settlement in the region.
Dilated cardiomyopathy phenotype in Callithrix penicillata (E. Geoffroy, 1812): Case report
Authors: de Souza Balbueno Melina Castilho , Martins Jéssica Amâncio , Malaga Soraya Kezam , Forato Juliana , de Paula Coelho Cidéli 
Published: September 2023

AbstractDilated cardiomyopathy (DCM) is a disease of the heart muscle diagnosed by alterations resulting from ventricular systolic dysfunction with enlargement of the heart chambers, which is still underdiagnosed in non‐human primates. This report is the first case of the DCM phenotype diagnosed by echocardiography and confirmed by necropsy in Callithrix penicillata.
Mutational screening of Greek patients with axonal Charcot‐Marie‐Tooth disease using targeted next‐generation sequencing: Clinical and molecular spectrum delineation
Authors: Kontogeorgiou Zoi , Kartanou Chrisoula , Rentzos Michail , Kokotis Panagiotis , Anagnostou Evangelos , Zambelis Thomas , Chroni Elisabeth , Dinopoulos Argyris , Panas Marios , Koutsis Georgios , Karadima Georgia 
Published: September 2023

AbstractBackground and AimsAxonal forms of Charcot‐Marie‐Tooth disease (CMT) are classified as CMT2, distal hereditary motor neuropathy (dHMN) or hereditary sensory neuropathy (HSN) and can be caused by mutations in over 100 genes. We presently aimed to investigate for the first time the genetic landscape of axonal CMT in the Greek population.MethodsSixty index patients with CMT2, dHMN or HSN were screened by a combination of Sanger sequencing (GJB1) and next‐generation sequencing custom‐made gene panel covering 24 commonly mutated genes in axonal CMT.ResultsOverall, 20 variants classified as pathogenic or likely pathogenic were identified in heterozygous state in 20 index cases, representing 33.3% of the cohort. Of these, 14 were known pathogenic/likely pathogenic and six were designated as such according to ACMG classification, after in silico evaluation, testing for familial segregation and further literature review. The most frequently involved genes were GJB1 (11.7%), MPZ (5%) and MFN2 (5%), followed by DNM2 (3.3%) and LRSAM1 (3.3%). Single cases were identified with mutations in BSCL2, HSPB1 and GDAP1.InterpretationA wide phenotypic variability in terms of severity and age of onset was noted. Given the limited number of genes tested, the diagnostic yield of the present panel compares favourably with studies in other European populations. Our study delineates the genetic and phenotypic variability of inherited axonal neuropathies in the Greek population and contributes to the pathogenicity characterization of further variants linked to axonal neuropathies.
Should oral care be about more than a gut feeling? A qualitative study investigating patients' and healthcare professionals' experiences
Authors: Rasmussen Line Louise , Vaupell Karina Hesselvig , Olsen Marlene Lynggaard , Nielsen Charlotte 
Published: September 2023

AbstractAimTo explore patients' and healthcare professionals' (HCPs) experiences of oral care during hospitalisation to identify needs and challenges.BackgroundDaily oral care is important to patients' health and well‐being, to prevent diseases in the oral cavity, systemic infections and increased morbidity, which subsequently can lead to prolonged hospitalisation and, at worst, increased mortality. Despite this knowledge, oral care is a neglected part of nursing practice. Studies do not clearly identify barriers regarding oral care, as the existing knowledge is inadequate.DesignA qualitative study exploring participants' experiences to gain new in‐depth knowledge of oral care among hospitalised patients.MethodsA phenomenological‐hermeneutic approach was applied. Participant observations were conducted on five hospital wards, combined with individual semi‐structured interviews with 16 patients and 15 HCP. Data analysis was based on Ricoeur's theory of narrative and interpretation.ResultsFour themes describing the challenges regarding oral care emerged: Oral care as a gut feeling; oral care fades into the background; even self‐reliant patients need help with oral care; and the mouth reflects the life lived.ConclusionsThe identified challenges show there is a need for improvement in the health professional approach to oral care in nursing practice. Focus on increasing HCPs' knowledge, skills and competences can increase their nursing agency and support patients' self‐care capacity.ImpactInvestigation of oral care during hospitalisation revealed four main challenges concerning both patients' and HCPs' lack of knowledge and awareness of oral care. Thus, patients and HCPs should be included in developing solutions to improve oral care in nursing practice.Reporting methodsThe COREQ criteria for reporting qualitative research were adhered to.Patient contributionA patient representative was involved in the discussion of the proposal, conduct and results of the study.
The relationship between perception of COVID‐19, fear of COVID‐19 and self‐care management in individuals with chronic diseases during the pandemic process in Turkey
Authors: Kılıç Züleyha , Günaydın Yurdagül , Yıldırım Tekin , Aydınlı Ayşe 
Published: September 2023

AbstractAimsTo determine the relationship between perception of COVID‐19, fear of COVID‐19 and self‐care management in individuals with chronic diseases during the pandemic process.BackgroundIndividuals with chronic diseases are a sensitive group during the COVID‐19 pandemic process; it is thought that self‐care management may be adversely affected as a result of their more intense exposure to the psychological, physiological and economic effects of the pandemic. In the literature, there is no study examining the effect of perception of COVID‐19 and fear of COVID‐19 on self‐care management in individuals with chronic diseases.DesignDescriptive study.MethodsThe study was conducted with 322 individuals who applied to the internal medicine outpatient clinics of a university's Health Practice and Research Center, met the inclusion criteria, agreed to participate in the study and had a chronic disease. Questionnaire form, Perception of COVID‐19 Scale (P‐COVID‐19), The Fear of COVID‐19 Scale (FCV‐19S) and Self‐Care Management Process in Chronic Illness Scale (SCMP‐G) were used to collect data. STROBE checklist was used to report the present study.ResultsIn the study, it can be stated that individuals with chronic diseases had a moderate to the high perception of contagiousness and dangerousness of COVID‐19, they had a moderate‐high level of fear of COVID‐19 and their self‐care care management was above moderate level. There was a significant positive correlation between P‐COVID‐19, FCV‐19S and SCMP‐G in the study.ConclusionsIt was found that the perception of COVID‐19 contagiousness and the fear of COVID‐19 had a positive effect on the self‐care management of individuals with chronic diseases.Relevance to clinical practiceDetermining the level of COVID‐19 perception and fear of COVID‐19 and their effects on the life of the individual, and evaluating self‐care management during the difficult pandemic process will increase the success in the holistic nursing care and management of chronic diseases.
Is low back pain a risk/prognostic factor for the development and/or progression of temporomandibular disorders? A systematic review with meta‐analysis
Authors: Justribó‐Manion C. , Mesa‐Jiménez J. , Caballero‐Ruiz‐de‐la‐hermosa C. , Zuil Escobar J. C. , Armijo‐Olivo S. 
Published: September 2023

AbstractObjectivesTo evaluate the association between low back pain (LBP) and painful temporomandibular disorders (TMDs).MethodsSystematic review of observational studies. Searches were conducted using OVID MEDLINE, CINHAL, Web of Science and PUBMED databases up to 21 October 2022. Qualitative and quantitative analyses were performed. Risk of bias (RoB) was assessed using the Quality in Prognosis Studies tool (QUIPS).ResultsEight studies were included in the present review with meta‐analysis. The first onset of TMDs was more likely in patients with previous chronic LBP (hazard ratio (HR) 1.53 [95% confidence interval (CI): 1.28; 1.83,p < .00001]). In addition, patients with chronic LBP had 3.25 times the odds (OR) [95% CI: 1.94; 5.43,p < .00001] of having chronic TMDs than those who did not have chronic LBP. In addition, the higher the exposure to chronic LBP, the higher the risk of developing a first onset of TMDs.ConclusionsChronic LBP can be considered a risk/contributing factor for painful TMDs. Although there is a high certainty in the evidence linking chronic LBP with the risk of a first onset of TMDs, there are insufficient studies to draw definitive conclusions. Furthermore, while an association between chronic LBP and chronic TMDs and a dose–effect was observed between these two conditions, a limited number of studies and evidence exist to support these findings. Future studies are needed to increase the body of evidence.
Beyond conflict: Kinship theory of intragenomic conflict predicts individual variation in altruistic behaviour
Authors: Bresnahan Sean T. , Galbraith David , Ma Rong , Anton Kate , Rangel Juliana , Grozinger Christina M. 
Published: September 2023

AbstractBehavioural variation is essential for animals to adapt to different social and environmental conditions. The Kinship Theory of Intragenomic Conflict (KTIC) predicts that parent‐specific alleles can support different behavioural strategies to maximize allele fitness. Previous studies, including in honey bees (Apis mellifera), supported predictions of the KTIC for parent‐specific alleles to promote selfish behaviour. Here, we test the KTIC prediction that for altruism‐promoting genes (i.e. those that promote behaviours that support the reproductive fitness of kin), the allele with the higher altruism optimum should be selected to be expressed while the other is silenced. In honey bee colonies, workers act altruistically when tending to the queen by performing a ‘retinue’ behaviour, distributing the queen's mandibular pheromone (QMP) throughout the hive. Workers exposed to QMP do not activate their ovaries, ensuring they care for the queen's brood instead of competing to lay unfertilized eggs. Due to the haplodiploid genetics of honey bees, the KTIC predicts that response to QMP is favoured by the maternal genome. We report evidence for parent‐of‐origin effects on the retinue response behaviour, ovarian development and gene expression in brains of worker honey bees exposed to QMP, consistent with the KTIC. Additionally, we show enrichment for genes with parent‐of‐origin expression bias within gene regulatory networks associated with variation in bees' response to QMP. Our study demonstrates that intragenomic conflict can shape diverse social behaviours and influence expression patterns of single genes as well as gene networks.
Clinical factors associated with systemic sporotrichosis in Brazil
Authors: Magalhães Vanessa C. R. , Colombo Salene A. , Peres Nalu T. A. , Moura Alexandre S. , Lyon Ana C. , Lyon Sandra , Dutra Maria R. T. , Fereguetti Tatiani O. , Andrade Virginia A. , Azevedo Maria I. , Santos Daniel A. 
Published: September 2023

AbstractBackgroundSystemic sporotrichosis occurs when organs, other than subcutaneous tissues and lymph nodes, are infected. Interestingly, systemic sporotrichosis in apparently immunocompetent individuals is increasing in Brazil, but data on clinical manifestations and risk factors are scarce. Most of the existing data on such condition relate to people living with HIV. We aimed to study the risk factors associated with systemic sporotrichosis among HIV‐negative and HIV‐positive patients.MethodsWe performed a retrospective cross‐sectional study with 80 patients from Brazil, diagnosed between 2014 and 2021. The association between disease classification, clinical presentation and risk factors were analysed by logistic regression.ResultsOf the 80 patients, 29 (36.3%) presented with systemic sporotrichosis. All HIV‐positive patients developed the systemic form, with increased mortality (p = .002). Alcohol ingestion (p = .009) and diabetes (p = .010) were associated with systemic disease. Alcohol ingestion seemed to favour pulmonary infection (p = .013) and, diabetes favoured osteoarticular (p = .009) and ocular involvement (p = .033). The occurrence of fever (p = .001) and weight loss (p = .006) were significantly associated with systemic sporotrichosis, while meningeal involvement (p = .001) increased mortality risk. Nine (11.3%) patients died from sporotrichosis. The presence of fungal structures in the mycological examination of the patients' lesions were associated with the systemic form (p = .017) and death (p = .002).ConclusionOur study points to the factors that drive systemic sporotrichosis other than HIV, such as alcohol ingestion and diabetes. Considering the high number of patients presenting severe sporotrichosis, the recognising these factors may contribute to timely diagnosis and proper treatment.