bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Prunus Tomentosa Thumb Total Flavones on adjuvant arthritis in rats and regulation of autophagy
Authors: Chen Xi , Sun Lijuan , Wang Shuang , Wang Yilin , Zhou Yue , Li Yan , Cheng Zihao , Wang Yingying , Jiang Yanan , Zhao Zihan , Xv Yawei , Zhang Chengyi 
Published: April 2023

BACKGROUND: Rheumatoid arthritis (RA) is a slow in taking effect systemic autoimmune disease. Prunus Tomentosa Thumb Total Flavones (PTTTF) has anti-inflammatory and antioxidant properties. OBJECTIVE: The purpose of this study is to the PTTTF on adjuvant arthritis (AA) in rats and to explore the mechanism of autophagy. METHODS: Adjuvant arthritis model was established in rats. The cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-17 (IL-17), tumor necrosis factor (TNF-α) of rat synovial tissue were determined by RT-PCR. The histopathological varieties of knee joints in AA rats were observed by HE staining. The expressions of autophagy-related proteins ATG5, ATG7, ATG12, Beclin1, Lc3II and Bcl-2 in rat synovial tissue were determined by Western Blotting. RESULTS: PTTTF (50, 100, 200 mg/kg) significantly inhibited inflammation in rats (P< 0.01). PTTTF significantly inhibited inflammatory factor COX in rat synovial tissue. COX-2, IL-1β, IL-6, IL-17, TNF-α expression (P< 0.05); PTTTF can significantly improve the pathological damage of rat knee joint PTTTF and can significantly inhibited the expression of autophagy-related proteins in rat synovium (P< 0.05 ). CONCLUSION: PTTTF can inhibit adjuvant arthritis in rats and can inhibit the expression of autophagy-related proteins ATG5, ATG7, ATG12, Beclin1, Lc3II and Bcl-2.
Medium and large alleles of the PGC gene are risk factors for gastric cancer
Authors: Sánchez-López Josefina Yoaly , Vázquez-Ibarra Katia Carolina , García-Muro Andrea Marlene , García-Ruvalcaba Azaria , Pacheco-Sotelo Sergio , Díaz-Herrera Luis Carlos , Marin-Contreras Marıa Eugenia 
Published: April 2023

BACKGROUND: A 100-bp insertion/deletion polymorphism in the pepsinogen C gene has been associated with the risk of gastric cancer (GC). OBJECTIVE: We analyzed the relationships of the 100-bp insertion/deletion polymorphism with GC, atrophic gastritis (AG), and intestinal metaplasia (IM) in the Mexican general population (MGP). METHODS: We studied the genomic DNA of subjects with GC n = 80, AG and IM n = 60, controls n = 110, and the MGP n = 97. PGC gene insertion/deletion polymorphism was identified by means of PCR, capillary electrophoresis and GeneScan software. RESULTS: Different allele sizes of PGC polymorphism were observed in the studied groups, from 266 bp to 499 bp, which were grouped for the analysis as short alleles of 266–399 bp, medium alleles of 400–433 bp and large alleles of 434–499 bp. Carriers of one or two medium alleles, had an increased risk of GC, with OR of 1.99 (CI95% 1.08–3.67 p = 0.026) compared to homozygotes (no medium/no medium). CONCLUSIONS: Previous studies have related PGC short alleles to risk for or protection against GC depending on the ethnic origin of the population. In our study, medium alleles were related to risk for GC. Further studies are required to establish the importance of this polymorphism in the origin of gastric neoplasia.
Food Intolerance and Sensitivity Are Associated With Chronic Musculoskeletal Pain in a Self-Selected Community Population
Authors: Thomson Ella , Beer Harriet , Ryan Laura , Philcox Edward , Kelly Clive 
Published: April 2023

INTRODUCTION People are presenting with chronic musculoskeletal pain at a younger age, and many fulfil criteria for fibromyalgia. We have recently shown a strong association between fibromyalgia symptoms and autistic traits in a self-selected community population, with the relationship mediated in part by the presence of hypermobility. Many respondents also described food sensitivities and intolerances. This study explores the relationships between food issues and fibromyalgia symptoms in this population METHODS The study used a nonexperimental, correlational design with data collected from a volunteer sample of 442 adults (aged 18-60) who completed online self-report questionnaires assessing each of fibromyalgia symptoms (ACR criteria), autistic traits (RAADS score) and hypermobility (Beighton’s test). Subjects were also asked to record any food sensitivities, allergies, or intolerances, along with their consequences. Correlation analyses and linear regressions were used to test the relationships between these features and each of fibromyalgia, autistic traits and hypermobility. Data was analysed using parametric and non-parametric techniques to assess the strength and significance of relationships, and the potential mediating effect of food-related symptoms in the correlation between fibromyalgia features and autistic traits RESULTS Our self-selected community population had a mean age of 24 years and was 77% female. The prevalence of fibromyalgia, autistic traits and hypermobility was 40%, 65% and 44% respectively. Half of all subjects reported food sensitivity and 31% reported food intolerance. The incidence of food-related symptoms was higher among subjects who met criteria for fibromyalgia than those who reported autistic traits or hypermobility. Food sensitivity and food intolerance were both more significantly associated with fibromyalgia (r=0.24, p>0.001 and r=0.38, p>0.001) than with autistic traits (r=0.15, p>0.01 and r=0.17, p>0.01). DISCUSSION This is the first community study to provide evidence for a direct association between features of fibromyalgia and reported food intolerance and sensitivity. Although self-selected, the findings in our predominantly young population suggest that gluten and lactose consumption may be associated with higher levels of musculoskeletal pain. The study population commonly reported that avoidance of gluten and / or lactose containing foods reduced symptoms. Dietary adjustment may merit further investigation as a therapeutic modality for some patients with fibromyalgia.
Prevalence of toxoplasmosis among miscarried women and the effect on embryo in Thi -Qar province southern – Iraq
Authors: salman abdulhasan Ahmed 
Published: April 2023

Toxoplasma gondii is a widespread worldwide and is one of the causes of miscarriage in women who are pregnant .Toxoplasma gondii infection among miscarried women in Thi-Qar province was investigated in this study. A total of 120 blood samples of aborted women and 80 samples of blood were taken from women who had not undergone miscarriage while pregnant (comparison group) and for the period from November 2018 to January 2019 and with ages ranging from 15 to 44 years. Anti-Toxoplasma IgM and IgG antibodies were detected using an enzyme-linked immunosorbant assay (ELISA).The results showed that the total incidence of T. gondii among women with miscarriage was 59/120 (49.1%) compared with the standard group (women without miscarriage) 5/80 (6.2%). The rate of infection was IgG 41.6%, IgM 5% and IgG & IgM togather 2.5% among miscarried women. The age group with the highest percentage was the range of (25-34) year ,was(45.7%) and the lowest percentage was 22 % in the range of ( 35-44 )year age range. The highest rate of infection was in the first period of pregnancy 52.5% and the lowest was in the third period of pregnancy 18.6% women who had a single miscarriage have the highest prevalence of infection (44%) and the lowest was in women who have multiple miscarriage (23.7%).
Finding Children of Compost Symbionts
Authors: Chan Clara 
Published: April 2023

This project explores the use of simple craft techniques as resistance, and is a response to Haraway's call for "collaborative and divergent story-making practice" in her Camille Stories: Children of Compost (2016). I use compost as a figuration that articulates life in the damaged world. Living is composting. This project seeks to inspire curious and open thinking, and to build a "dialogical bridge between knowledge systems” (Rose, 2020). Through the agency of my Children of Compost Symbionts (an organism living in symbiosis with another), this project aims to engage the public in constructive public discourse in order to find hope, care and empathy in the broken world. The symbionts appropriate traditional handcrafted toys, like dolls and bears, and work in the way that psychoanalyst Donald Winnicott called "transitional objects" (Levy, 2021) work for children: they carry our anxieties, rage, love, and most secret thoughts, and live the life on our behalf. These whimsical symbionts inspire the public to tell their own stories of remediation and repair, encourage the public to create new perspectives and approaches, and engage with a multiplicity of otherness ethically.
Pengaruh Struktur Good Corporate Governance Terhadap Tax Avoidance
Authors: Cristan Yeni , Poniman Poniman 
Published: April 2023

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Taxes are the largest income in Indonesia, but there are still many tax-payer who are negligent in fulfilling their tax obligations. The companies think that high tax payments reduce operating profits and hinder the development of the company. Company managers often commit fraud in order to get large profits, which is why corporate governance is very necessary in controlling the company. This research was conducted to test the effect of Good Corporate Governance to Tax Avoidance. The independent variables in this study were proxied from Good Corporate Governance which include Managerial Ownership, Institutional Ownership, Board of Independent Commissioners and Audit Committee, while the dependent variable is Tax Avoidance which measured by Effective Tax Rate. This research used a quantitative approach with associative form to determine the correlation between variables. The population of this study is consumer goods industry sector company listed on Indonesia Stock Exchange for 2017-2021 period. The sampling technique used is purposive sampling, where samples of 14 companies were collected within five years,and obtain 62 samples after outlier. The data analysis methods used are descriptive statistical tests, classical assumption tests, multiple linear regression analysis and hypothesis tests. The results showed that Managerial Ownership, Institutional Ownership and Audit Committee partially did not significantly effect Tax Avoidance, while the Board of Independent Commissioners had a significant negative effect on Tax Avoidance. Managerial Ownership, Institutional Ownership, Board of Independent Commissioners and Audit Committee simultaneously do not effect Tax Avoidance.
Potential effective diagnostic biomarker in patients with primary and metastatic small intestinal neuroendocrine tumors
Authors: Chen Jianxian , Meng Yiliang , Huang Xiaojuan , Liao Xuegan , Tang Xiaochun , Xu Yuanchao , Li Jie 
Published: April 2023

Background: Small intestinal neuroendocrine tumors (SI-NETs) are the most common malignant tumors of the small intestine, with many patients presenting with metastases and their incidence increasing. We aimed to find effective diagnostic biomarkers for patients with primary and metastatic SI-NETs that could be applied for clinical diagnosis.Methods: We downloaded GSE65286 (training set) and GSE98894 (test set) from the GEO database and performed differential gene expression analysis to obtain differentially expressed genes (DEGs) and differentially expressed long non-coding RNAs (DElncRNAs). The functions and pathways involved in these genes were further explored by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. In addition, a global regulatory network involving dysregulated genes in SI-NETs was constructed based on RNAInter and TRRUST v2 databases, and the diagnostic power of hub genes was identified by receiver operating characteristic curve (ROC).Results: A total of 2,969 DEGs and DElncRNAs were obtained in the training set. Enrichment analysis revealed that biological processes (BPs) and KEGG pathways were mainly associated with cancer. Based on gene set enrichment analysis (GSEA), we obtained five BPs (cytokinesis, iron ion homeostasis, mucopolysaccharide metabolic process, platelet degranulation and triglyceride metabolic process) and one KEGG pathway (ppar signaling pathway). In addition, the core set of dysregulated genes obtained included MYL9, ITGV8, FGF2, FZD7, and FLNC. The hub genes were upregulated in patients with primary SI-NETs compared to patients with metastatic SI-NETs, which is consistent with the training set. Significantly, the results of ROC analysis showed that the diagnostic power of the hub genes was strong in both the training and test sets.Conclusion: In summary, we constructed a global regulatory network in SI-NETs. In addition, we obtained the hub genes including MYL9, ITGV8, FGF2, FZD7, and FLNC, which may be useful for the diagnosis of patients with primary and metastatic SI-NETs.
The evolving culture of medical cannabis in Canada for the management of chronic pain
Authors: Clarke H. , Fitzcharles M. 
Published: April 2023

Although used therapeutically for millennia, cannabis has been a prohibited substance worldwide for most of the 20th Century. With revision of prohibitive regulations in many jurisdictions during the past 2 decades, cannabis is increasingly available to patients as a potential treatment option for various symptoms. Pain relief, sleep promotion and alleviation of distress, depression and anxiety are the most common reasons for cannabis use. Canada has been at the forefront of medical cannabis (MC) legislation revisions to enable and facilitate access for therapeutic use. Although initially viewed with caution and stigma, attitudes to cannabis in general have changed. Medical cannabis is identified as the herbal plant product sourced from a grower/producer and is not at present a regulated pharmaceutical product. Medical cannabis use is currently prevalent in Canada but has bypassed the rigorous study required for usual drug approval. Although uptake has been enthusiastic by patients, the medical community has voiced cautions and concerns. Access to medical cannabis is fairly easy once an approval document is obtained from a healthcare professional, but without obligation for medical or pharmacy oversight. The greatest concern is a dearth of sound clinical evidence for effects and harms. Emerging concerns include prevalent patient self-management with information based on personal research, an abundance of on-line information which may not always be accurate, the emergence of designated “cannabis clinics,” potential risks to society due to accidents, and high cost of the legal medical product leading to access via the recreational market. With cannabis now entrenched in Canadian healthcare, physicians must be sufficiently knowledgeable to provide guidance that is evidence-based and will ensure personal and societal harm reduction. Examination of the changing culture of medical cannabis in Canada will provide insight for countries that may be anticipating similar revisions of cannabis regulations to allow cannabis access for their patient population and learn from the issues created by recreational legalization.
Similarity analysis of the flow-induced noise of a benchmark submarine
Authors: Qu Yao , Zhang Yong-Ou , Li Yi-Fan , Zhang Tao 
Published: April 2023

As one of the three major noise sources of submarines, flow-induced noise plays a key role for the stealth capability of submarines. Several research studies based on experiment or simulation have evaluated the sound radiation from the scale model; however, it is still a great challenge to efficiently evaluate the flow-induced noise of a large-scale prototype. In order to solve this problem, the flow-induced noise of different scale submarines is analyzed, and both the similarity law and the scale effect are discussed in the dimensionless frequency St = 10–1089. The fully appended DARPA SUBOFF, a famous benchmark submarine model, is used in our research. The relationship between the sound power, scale variables, and the speed and scale variables is obtained using the Buckingham Pi theorem. Then, the sound pressure level and the sound power level of the SUBOFF, with the scale ratio of 1:24 and 1:48 and the speed of 2, 4, and 8 m/s, are calculated based on the large-eddy simulation (LES)/Lighthill hybrid method. Finally, the scale effect between a hypothetical prototype (actually, a benchmark SUBOFF model with a scale ratio of 1:8) and its scale models are discussed at the same speed. The numerical results show that the submarine’s sound power level conforms to the similarity relationship of dipole source within the cut-off frequency St = 100. The error of the sound power level is about 20 lg (φ) caused by scale effect when the dimensionless frequency is greater than the cut-off frequency, where φ is the scale ratio from the hypothetical prototype to the model. The scale error of the sound pressure level at different position and different frequency exist differently when extrapolating from model results to prototype according to the similarity law based on dipole source.
Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited
Authors: Stoks Job , Bear Laura R. , Vijgen Johan , Dendale Paul , Peeters Ralf , Volders Paul G. A. , Cluitmans Matthijs J. M. 
Published: April 2023

Background: The optimal way to determine repolarization time (RT) from the intracardiac unipolar electrogram (UEG) has been a topic of debate for decades. RT is typically determined by either the Wyatt method or the “alternative method,” which both consider UEG T-wave slope, but differently.Objective: To determine the optimal method to measure RT on the UEG.Methods: Seven pig hearts surrounded by an epicardial sock with 100 electrodes were Langendorff-perfused with selective cannulation of the left anterior descending (LAD) coronary artery and submersed in a torso-shaped tank containing 256 electrodes on the torso surface. Repolarization was prolonged in the non-LAD-regions by infusing dofetilide and shortened in the LAD-region using pinacidil. RT was determined by the Wyatt (tWyatt) and alternative (tAlt) methods, in both invasive (recorded with epicardial electrodes) and in non-invasive UEGs (reconstructed with electrocardiographic imaging). tWyatt and tAlt were compared to local effective refractory period (ERP).Results: With contact mapping, mean absolute error (MAE) of tWyatt and tAlt vs. ERP were 21 ms and 71 ms, respectively. Positive T-waves typically had an earlier ERP than negative T-waves, in line with theory. tWyatt -but not tAlt-shortened by local infusion of pinacidil. Similar results were found for the non-invasive UEGs (MAE of tWyatt and tAlt vs. ERP were 30 ms and 92 ms, respectively).Conclusion: The Wyatt method is the most accurate to determine RT from (non) invasive UEGs, based on novel and historical analyses. Using it to determine RT could unify and facilitate repolarization assessment and amplify its role in cardiac electrophysiology.
Fungal Diversity Associated with Armadillidium Isopods: A Case Study in Central Park of Gwacheon, South Korea
Authors: Cha Yehyeon , Oh Seung-Yoon 
Published: April 2023

The symbiotic relationship between macroorganisms, such as plants and animals, and the microorganisms in their environment plays a crucial role in shaping their physiology and ecology. Thus, many studies have examined microbial symbiosis in relation to plants, humans, and insects. However, little is known about the microbial diversity associated with isopods. Hence, in this study, we investigated the fungal diversity associated with two species of terrestrial isopods, Armadillidium nasatum and A. vulgare. In this study, we used a metabarcoding approach to compare fungal diversity between the two species for the first time. Our results indicated that A. nasatum had significantly greater mycobiome alpha diversity than A. vulgare. In contrast, fungal communities (beta diversity) did not differ significantly between hosts, except in beta dispersion of relative abundance. The majority of fungi identified belonged to Ascomycota and Basidiomycota, phyla that are dominated by saprotrophs. In conclusion, our findings shed light on the fungal communities associated with Armadillidium species, providing valuable insight into the biology of terrestrial isopods.
Numerical Modeling of Thermochemical Conversion of Biomass and Tires as Fuels for Cement Clinker Production
Authors: Mungyeko Bisulandu Baby-Jean Robert , Marias Frédéric 
Published: April 2023

This article presents the numerical modeling of the thermochemical conversion of biomass and tires as alternative fuels in kilns dedicated to the production of cement. The study seeks to understand and control the phenomena that occur when heavy fuel oil (traditional fuel) is partially replaced by biomass and tires. These are thoroughly mixed with meal at the entrance to the rotary kiln and form the bed of solids. The mathematical model developed takes into account both chemical reactions of meal and alternative fuels. At the entrance, the meal is made up of species such as CaCO3, MgCO3, Al2O3, SiO2, Fe2O3, MgO, CaO, C2S, C3A, C4AF and C3S, some of which form along the kiln. The article focuses specifically on the influence of alternative fuels on the clinker or cement obtained. The properties (moisture, organic matter, composition, energy value, etc.) of the biomass and the tires, which are associated with the operating parameters of the kiln, greatly influence the production of clinker. In order to understand and control the behavior of each material and the operating parameters in the clinker (cement) production process, the mathematical model follows the evolution of each species and parameters step-by-step, until the clinker is obtained. The effect of alternative fuels on clinker production was found for the kiln’s operational parameters, the dynamic angle of the bed (30°), the angle of inclination of the kiln (2°), rotation (2 rpm), the length and the inside diameter, respectively (80 m) and (4 m); the chemical and physical properties (humidity, organic, inorganic matter, C, H, O, N, S, Cl); the lower calorific value, raw material); and the numerical parameters (spatial discretization 30 and 120). Despite the high energy content of tire fuels, the results of the use of biomass give better characteristics of clinker/cement (52.36% C3S and 3.83% CaO).The results found show that biomass pyrolysis is endothermic, with the heat of reaction found to be ∆rHpyro=184.9 kJ/kg, whereas for tires, a heat of reaction of ∆rHpyro=−1296.3 kJ/kg was found, showing that the pyrolysis of this material is exothermic. Char production is higher in the case of tires than in the case of biomass, with rates of 0.261 kg/kgOrg.Mat. and 0.196 kg/kgOrg.Mat., respectively. In both cases, waste conversion was complete (100%). The cement obtained in the different cases meets the requirements of Portland cements (73.06% silicates and 18.76% aluminates), the conversion of alternative fuels is complete (100%), and the specific energy consumption is almost consistent with values from the literature.