bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Mobile Phone-based Tele-monitoring of Cystic Fibrosis Patients during the COVID-19 Pandemic
Authors: Fadaizadeh Lida , Hassanzad Maryam , Valinejadi Ali , Taheri Seyed Mohammad Jafar , Farnia Poopak , Hassanzad Nima , Ghaffaripoor Hossein Ali , Baghaei Noushin , Arian Mahdieh , Ansari Masoumeh , Daneshmandi Zahra , Sadati Elham Sadat , Honarpisheh Parisa , Rekabi Mahsa , Mohammadpour Leila , Velayati Ali Akbar 
Published: August 2023

Background:
Telemedicine has been used for cystic fibrosis (CF) in a wide range of signs and symptoms even before the COVID 19 pandemic, however, little is known about the health consequences and use of specific health care for cystic CF. This study aimed to evaluate the evolution of clinical trends and data related to mobile based monitoring activities in CF patients at home for 3 years.

Methods:
This is a semi experimental single group study. Forty five CF patients under 7 years' old who were referred to the Masih Daneshvari Hospital between 2018 and 2021 were selected. A mobile phone_based customized Short Message Service (SMS) application used to monitor patients. Remotely monitored variables included the amount and color of sputum, cough, wheezing, and shortness of breath at rest. SPSS using Chi square and Friedman tests.

Results:
The condition of patients based on the number and type of cough increased sputum, decreased appetite, fatty stool, fever and dyspnea, headache, noninvasive ventilation, and drug comfortably remained almost unchanged in the study of the 1st, 2nd, and 3rd years, and the studied parameters did not show a significant difference (P > 0.05). Of course, the number of outpatient visits decreased significantly (P value: 0.02). The respiratory rate and arterial oxygen saturation variables were almost the same in three consecutive annual measurements (P values: 0.544 and 0.639, respectively).

Conclusion:
Telemedicine is a method that is useful in the follow up of chronic diseases such as CF and improves the quality of life and reduces the deterioration of lung function; therefore, there is less need for invasive treatments in the long run, and a fundamental change in referral motivation brings to the hospital.
Integrated Proteomic, Transcriptomic, and Genomic Analysis Identifies Fibrinogen Beta and Fibrinogen Gamma as Key Modulators of Breast Cancer Progression and Metastasis
Authors: Patadia Hemantkumar , Priyadarshini Ankita , Gangawane Ajit 
Published: August 2023

Background:
As per the WHO, more than 2 million new cases are diagnosed with breast cancer and more than 685,000 deaths have been reported in 2020. Incidence of recurrence and metastasis has also risen and poses a challenge for developing new therapies with the identification of newer targets.

Methods:
The objective of this study is to analyze and integrate various data across genomic, transcriptomic, and proteomic levels to find promising markers linked with tumor progression and metastasis development in breast cancer. This study begins with the extraction of data of differentially expressed proteins and subsequently analyzes their gene expression changes and genomic alterations to integrate all three omics data. We used curated breast cancer datasets of different proteomic experiments from dbDEPC3.0 and TCGA datasets of the Metastatic Breast Cancer Project to compare gene expressions and genomic alterations. We further used cBioportal, GeneMania, GEPIA2, Reactome, and canSAR computational tools for identifying the most significant genes associated with tumor progression and metastasis.

Results:
Based on false discovery rate, 14 genes were subjected to pathway analysis in Reactome and the top 25 significant pathways were analyzed out of a total of 170 pathways. Our study found fibrinogen gamma (FGG) and fibrinogen beta (FGB) linked to pathways connecting RAS-MAPK, its downstream mutants, integrin signaling, and extracellular matrix remodeling pathways.

Conclusion:
Survival analysis suggested that FGG (P = 0.0065) and FGB (P = 0.013) have a significant positive correlation along with their stage-wise changes in copy number variations and genomic alterations play a pivotal role in controlling tumor progression and metastasis.
Short-term outcomes of eTEP repair of ventral hernia in university hospital of Nepal
Authors: Mandal Bikash , Kumar Abhijeet , Agrawal Sunit , Sah Suresh , Gupta Rakesh Kumar 
Published: August 2023

Abstract

BACKGROUND:
Ventral hernia (primary and incisional) is one of the most frequently encountered problems by the General Surgeon. The enhanced view totally extraperitoneal (eTEP) technique for inguinal hernia was first described by J Daes, which was later used in ventral hernia repair for the first time by Belyansky et al. We applied the same technique for ventral hernia repair to see its feasibility in the context of our country.

MATERIALS AND METHODS:
It is a single-center prospective observational study of a patient who underwent eTEP (with or without TAR) by a single surgeon between September 2019 and May 2020 and followed up for 12 months. Patient demographics, hernia characteristics, operative details, perioperative complications, and satisfaction scores using the Likert scale were collected for data analysis.

RESULTS:
The study included 42 patients with 66% of female among them. The mean age was 51 ± 12.97 years, the mean BMI was 29.88 ± 2.16 kg/m2, and the mean ASA of patients was 1.5. Incisional hernia (74%) was the most common diagnosis. The mean operative time was less for the primary hernia (125.45 min) than for the incisional hernia (138.35 min). Intraoperative complications were seen in three (7%) of all the patients. Postoperative length of hospital stay was 1.8 days on average. Postoperative pain was low with only one of the patients having chronic pain while none had a recurrence on follow-up. All the patients were satisfied.

CONCLUSION:
eTEP is a feasible, cheap, and safe alternative MIS option as it has less morbidity and does not carry an extra cost of mesh in comparison to conventional procedures.
The future of robotics in the treatment of abdominal wall hernias: A narrative review
Authors: Huang Estella Y , Chung Daniel , Sandler Bryan J , Jacobsen Garth R , Horgan Santiago , Broderick Ryan C 
Published: August 2023

Abstract
Robotics has transformed the field of surgery, providing a tool that has greatly expanded the treatment of a multitude of surgical diseases. In hernia repair, robotic platforms have provided an alternative option that is superior to conventional laparoscopy in many aspects, including marked improvements in manipulation and visibility. Additionally, it is far more ergonomic for the surgeon. The increasing application of robotics has provided a space for the development of additional platforms and devices to address unmet needs. We review current state of the art and potential future uses and innovations in robotic hernia repair.
Evaluation of light weight large pore mesh versus heavy weight small pore mesh in total extraperitoneal repair of inguinal hernia
Authors: Singh Sarabjit , Rana Kiranjot , Walia Bhupinder S. , Pahuja Vivek , Dugg Pankaj 
Published: August 2023

BACKGROUND:The type of mesh to be used in laparoscopic groin hernia repair has always been debatable whether to use lightweight (LW) or heavyweight (HW) mesh. The study compares the lightweight large pore mesh with HW small pore mesh in total extraperitoneal groin (TEP) hernia repair and its outcome.MATERIALS AND METHODS:A total of 50 patients, who met the inclusion criteria, were randomized in the two groups. In group I (n= 25) LW large pore mesh (pore size 1 mm) was used whereas in group II (n= 25) HW small pore mesh (pore size < 0.65 mm) was used. Outcomes were observed with respect to complications, recurrence, and patient satisfaction. Statistical analysis was performed usingχ2test and studentttest.RESULTS:Mean age of the patients group I was 45 ± 18.52 while in group II it was 48.88 ± 20.529 years. The complication rates were comparable between the two groups. However, seroma formation was higher in group II. The occurrence of groin pain and foreign body sensation between the two groups was comparable after 6-month follow-up. No recurrence was reported in either of the groups.CONCLUSION:Although there was no significant difference between the two groups, but the present study showed some advantage of LW mesh over HW weight mesh in TEP with respect to complications and patient satisfaction.
Outcomes after laparoscopic transabdominal preperitoneal (TAPP) hernia repair in the emergency
Authors: Olivero Ayelen Andrea , Casas María Agustina , Angeramo Cristian Agustin , Schlottmann Francisco , Sadava Emmanuel Ezequiel 
Published: August 2023

Introduction:
Laparoscopic repair of groin hernia (LRGH) is widely accepted for elective cases, but its use in emergency cases remains controversial. We aimed to compare postoperative outcomes between elective and emergent transabdominal preperitoneal (TAPP) repairs.

Materials and Methods:
Patients undergoing emergent LRGH (EM-LR) using a TAPP technique between June 2014 and December 2019 were included for analysis. A case-control cohort of patients undergoing elective LRGH (EL-LR) in the same period was identified and matched (1:3) on gender, age, body mass index (BMI), American Society of Anesthesiologists (ASA) score, active smoking, and hypertension. Preoperative variables and postoperative outcomes were compared between both groups.

Results:
A total of 15 EM-LR were matched with 45 EL-LR. In patients undergoing EM-LR, the median time from onset of symptoms to surgery was 12 (1–168) h. No differences were found regarding the operative time (EM-LR: 107 min vs. EL-LR: 117 min, P = 0.37) and hernia defect size (EM-LR: 3.6 cm vs. EL-LR: 4.1 cm, P = 0.48). Although small bowel obstruction was observed in all emergent cases, no patients required enterectomy. Emergent cases were performed more frequently by specialist surgeons (EM-LR: 87% vs. EL-LR: 24%, P < 0.001). Mean hospital stay was 3.1 and 0.3 days after EM-LR and EL-LR, respectively (P < 0.001). Overall 30-day morbidity was similar between groups (EM-LR: 6.6% vs. EL-LR: 4.4%, P = 0.43). After a mean follow-up of 28.2 months, no recurrence was observed.

Conclusion:
EM-LR had similar overall morbidity and recurrence rates than elective repairs. Prompted surgical exploration and use of laparoscopy should be encouraged for the management of complicated inguinal hernias.
Robot-assisted laparoscopic repair in hiatal hernia with kyphosis: A case report with meta-analysis
Authors: Liu Qi , Wang Dianchen , Sun Zhao , Jiang Jianwu , Fu Yang 
Published: August 2023

Abstract

BACKGROUND:
Hiatal hernia is a high incidence disease, of which, partial patients requiring surgery have gastroesophageal reflux or dysphagia. Although minimally invasive surgery has been widely utilized in recent years, the optimal surgical therapy still remains controversial. In this study, we reported a kyphosis patient undergoing robot-assisted laparoscopic hiatal hernia repair and launched a meta-analysis aiming to evaluate the advantages of this surgery strategy.

MATERIALS AND METHODS:
Six databases (Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, EMBASE, ClincialTrials.gov database and Web of Science) were searched from inception to September 20, 2022. All studies describing the patients undergoing robotic hiatal hernia or laparoscopic hiatal hernia were included. And the meta-analysis was performed using R package meta (v6.0.0).

RESULTS:
We reported a 75-year-old female patient of short stature and with severe kyphosis was diagnosed with hiatal hernia and underwent a robotic surgery. For meta-analysis, 1,128 articles were identified in the initial database search, and among them, 6 articles were included in the final analysis. The results showed that robotic surgery had no advantage in operation time and intraoperative complications rate compared with traditional laparoscopic surgery (both P < 0.01). Regardless of the statistical significance, robotic surgery tended to have a lower conversion and postoperative complication rate, as well as the length of hospital stay.

CONCLUSIONS:
Robotics have some advantages in the surgical treatment of hiatal hernia compared with the conventional laparoscopic surgery, the use of which can facilitate the treatment for some challenging cases.
Prospects and challenges of robotic hernia surgery in China: A narrative review
Authors: Li Shaochun , Li Shaojie , Hou Dongsheng , Tang Jianxiong 
Published: August 2023

Abstract
The Da Vinci surgical robotic system has revolutionized the field of robotic surgery and has become one of the most ubiquitous and recognized systems in the robotic surgery era. The rapid rise in China’s economy will provide crucial support for the promotion and application of robotic surgical systems in the country’s surgical field. At present, approximately 1.2 million inguinal hernia repairs are performed annually in China. However, many of these surgeries are performed via traditional open repair or laparoscopy methods. Using the purported benefits of robotic surgery system to benefit hernia patients should become a future direction for Chinese hernia surgeons.
Repair of giant incisional hernias
Authors: Benek Suat , Pedük Şevki , Duran Yasin 
Published: August 2023

BACKGROUND:
Incisional hernias are one of the most common postoperative complications encountered by surgeons in daily practice. In our study, we compared the component separation technique (CST) with and without synthetic mesh in large incisional hernia surgery.

MATERIALS AND METHODS:
The files of 79 patients who underwent surgery for giant incisional hernia between January 2016 and November 2020 were reviewed retrospectively. The patients were divided into two groups: CST with mesh reinforcement (mesh+ group) and CST without mesh reinforcement (non-mesh group). The groups were compared in terms of recurrence, complications, and other clinical features.

RESULTS:
There were 36 patients in the mesh+ group and 38 patients in the non-mesh group. There was no significant difference between the two groups in terms of demographic parameters and clinical features. There was a statistically significant difference between the groups in terms of recurrence rate (P = 0.007, OR = 0.17). In addition, there was a significant difference between the two groups in terms of mean operation times (2.8 h and 1.9 h for mesh+ and non-mesh, respectively) (P = 0.000, 95% CI). Regardless of the use of mesh, recurrence was significantly higher in the presence of high body mass index (BMI) (P = 0.003, 95% CI) and comorbidity (P = 0.031, OR = 3.4).

CONCLUSION:
Repair of giant incisional hernias with mesh-reinforced CST is superior to the non-mesh technique in terms of hernia recurrence. Although CST without mesh reinforcement seems advantageous in terms of complications and operation time, we believe that the mesh-reinforced CST should be applied in suitable patients when the total cost, recurrence, and patient satisfaction are taken into account.
A novel hybrid approach to the repair of flank hernias
Authors: Chou Brendan P. , Bentley Karalyn , LeBlanc Karl A. 
Published: August 2023

Background:
Flank hernias are uncommon and challenging to repair. Discussion of flank hernia repair is scarce in the literature. We present a novel approach to repair flank incisional, traumatic, and denervation hernias with a “hybrid” approach using an open repair in conjunction with the robotic platform for laparoscopic intraperitoneal mesh fixation.

Materials and Methods:
A retrospective analysis was conducted on all patients who received a “hybrid” repair from April 2014 through January 2020 by a single surgeon. Patient and hernia characteristics, operative techniques, and outcomes were evaluated. Each patient underwent a similar operation with an intraperitoneal mesh as well as an onlay mesh. Minor technique changes including quilting and wound vac placement were developed and compared.

Results:
Twenty-five patients were included in the study. Outcomes analyzed included wound infection (8.0%), seroma formation (16.0%), hematoma formation (12.0%), mesh infection (0.0%), weight gain (16.0%), hernia recurrence (4.0%), reoperation (12.0%), and chronic pain (25.0%). Compared to the drain placement group, quilting of the subcutaneous tissue was more likely to result in seroma (17.6% vs. 12.5%, P = 0.618) and hematoma (17.6% vs. 0.0%, P = 0.296). Use of negative pressure incisional wound vac did not impact the incidence of wound infection (12.5% vs. 6.2%, P = 0.565), seroma (12.5% vs. 17.6%, P = 0.618), or hematoma formation (12.5% vs. 11.8%, P = 0.704).

Conclusion:
The “hybrid” repair represents a novel approach to flank hernias. Improved visualization of the intraperitoneal portions of the operation using the robotic platform allows for accurate mesh fixation. In experienced hands, this approach provides safe and satisfactory outcomes similar to a purely open repair.
A study to assess the prevalence of dental myths and misconceptions among the rural population of Daman
Authors: Vaghela Nilima , Lajpatrai Ankita , Dixit Arti 
Published: August 2023

Introduction:
It is important to know about the myths, especially in India, where general and oral health is embroiled in various myths.

Objectives:
The purpose of this study is to assess the prevalence of dental myths regarding oral health among the rural community of Daman.

Methodology:
A cross-sectional study was conducted in a rural area of Daman. A total of 500 individuals were included; data were collected using a pretested and validated 16-term questionnaire, including demographic data and questions regarding dental myths. Data obtained were statistically analyzed using descriptive statistics. Chi-square test is the statistical analysis used.

Results:
Almost all the participants believed in one or more dental myths. Majority of the participants, i.e., 80%, believed that oral cancer is not commonly found in older age group. About 92% of the participants felt that there was no necessity to consult a dentist in the absence of pain. Around 59% believed that extraction of the teeth of upper jaw causes loss of vision. There was an equally contradicting notion about bleeding gums while brushing.

Conclusion:
Various dental myths still lurk in the minds of the population; to discourage unhealthy practices, we the health professionals have to provide intensive health education and promote the adoption of healthy practices. It would be prudent to familiarize professionals with these myths and beliefs as they act as barriers to seeking treatment.
Assessment of Bacteriological Profile and Outcome of Empyema Thoracis of Hospitalized Children
Authors: Sadani Sweta , Das Mrinalini 
Published: August 2023

Background:
Empyema is often associated with the consequence of infection including pneumonia, tuberculosis, or lung abscess. This study was conducted to assess the clinico-etiological profile and outcomes of empyema thoracis cases.

Materials and Methods:
This was a prospective hospital-based observational study conducted from July 2019 to June 2020 which included patients of either sex, aged between 2 months to ≤12 years, with empyema thoracis confirmed by radiological evidence of pleural fluid. Clinico-etiological details were collected and presented using appropriate statistics.

Results:
A total of 42 patients were included in the study, of which 35.7% were aged between 4 and 7.99 years and 27 patients (64.3%) were male. Twenty (47.6%) patients had a history of cough for 7–14 days while eight had cough for >14 days; however, a total of 29 (87.9%) patients had breathing difficulty for ≤7 days. Chest pain was observed in 16.7% of patients. Chest X-ray showed that right side pleural effusion was more commonly affected than the left pleural effusion (69.0% vs. 31.0%). The most common micro-organism pleural fluid culture was Staphylococcus aureus (n = 8; 20.5%). The majority of patients with empyema thoracis had elevated levels of leukocytes (>11,000 cumm) and CRP levels (>10 mg/dL) [92.9% and 97.6%, respectively].

Conclusion:
The present study showed that most of the children presented at the age of 4–7.99 years with a male predominance. S. aureus was the major organism associated with pediatric empyema in this region.
Mouth Breathing During Sleep and Persistence of OSA after Adeno-Tonsillectomy in Non-Obese Children
Authors: Fung Brigitte Kim-yook , Lau Mei-yee , Leung Shuk-yu , Wong Rebecca Suk-yin , Kwok Ka-li , Ng Daniel Kwok-keung 
Published: August 2023

Objective:
To evaluate the relationship between the percentage of total sleep time with mouth breathing (SMBP) and post-adeno-tonsillectomy apnea-hypopnea index (AHI) in non-obese children.

Materials and Methods:
Non-obese obstructive sleep apnea (OSA) children with pre- and post- TandA PSG done between August 2011 and February 2019 were reviewed and mouth breathing during sleep was manually scored. Percentage of total sleep time with mouth breathing (SMBP) was calculated. Its correlation with post-operative AHI >1.5/h was studied.

Results:
Fifty-nine children were included in the analysis and 47 of the study group (79.7%) were male. The mean age at pre-operative PSG was 9.2+/-3.1 years. The mean AHI dropped from 8.3+/-19.8 to 4.1+/-11.6 (P < 0.001). Thirty-one (50.8%) were cured of OSA defined as AHI<=1.5/h. There was a statistically significant positive correlation between post-operative log-transformed AHI and log-transformed SMBP (r=0.265, P = 0.044). The optimal SMBP for detecting residual OSA was 10.5%. The sensitivity, specificity, positive predictive value, negative predictive value and Youden Index were 0.86, 0.37, 0.57, 0.73 and 0.23, respectively. Post-operative children with SMBP >10.5% had higher risk for residual OSA (OR 4.2, 95%CI: 1.2–15.0, P = 0.029).

Conclusion:
Obstructive sleep apnea children with mouth breathing for more than 10.5% of total sleep time are more likely to have residual OSA after TandA.
Improved BAT Algorithm Using Density-Based Clustering
Authors: Al-Asadi Samraa , Al-Mamory Safaa 
Published: August 2023

BAT algorithm is a nature-inspired metaheuristic algorithm that depends on the principle of the echolocation behavior of bats. However, the algorithm suffers from being stuck in the local optima early due to its poor exploration. An improved BAT algorithm based on the density-based clustering technique is proposed to enhance the algorithm’s performance.
In this paper, the initial population is improved by generating two populations, randomly and depending on the clusters’ center information, and by getting the fittest individuals from these two populations, the initial improved one is generated. The random walk function is improved using chaotic maps instead of the fixed-size movement, and so the local search is improved as well as the global search abilities by diversifying the solutions. Another improvement is to deal with stagnation by partitioning the search space into two parts depending on the generated clusters’ information to obtain the newly generated solution and comparing their quality with the previously generated solution and choosing the best.
The performance of the proposed improved BAT algorithm is evaluated by comparing it with the original BAT algorithm over ten benchmark optimization test functions. Depending on the results, the improved BAT outperforms the original BAT by obtaining the optimal global solutions for most of the benchmark test functions.