bluuebunny/crossref_metadata_2025_split huggingface dataset:
The recent Nipah virus outbreak in Bangladesh could be a threat for global public health: A brief report
Authors: Nazmunnahar  , Ahmed Iftekhar , Roknuzzaman A. S. M. , Islam Md. Rabiul 
Published: July 2023

AbstractThe Nipah virus is a zoonotic infection that can potentially be transmitted from person to person as well as through ingesting contaminated food. It has a high fatality rate, and no treatment or cure at present. Several nations in South Asia have reported Nipah virus outbreaks occurred during a particular season of the year. Since it was first found in Bangladesh in 2001, there have been a total of 335 people infected with it, and 237 of those people have passed away as a result of their infection. With increased public awareness, community engagement, and preventative measures, this potentially fatal virus has been suppressed. Yet, following a pandemic and a considerable increase in the health burden, the transmission rate continuously increased over a few years, indicating that there is a growing possibility to become a global public health concern. Without effective vaccines and reliable treatment options, its capacity for human‐to‐human transmission and potential to spread throughout the area could result in a disastrous public health emergency worldwide.
The effect of a training program on the self‐care efficacy of hemodialysis patients with mineral and bone disorders: A quasi‐experimental study
Authors: Tashakor Sedigheh , Bagherian Behnaz , Salmanpour Zahra , Mehdipour‐Rabori Roghayeh 
Published: July 2023

AbstractBackground and AimsPatients who have chronic kidney disease (CKD) and mineral and bone disorders (MBD) often do not know much about their diseases. A training program can help them improve their quality of life. This study aimed to assess the effect of a training program on the self‐care efficacy of the hemodialysis patients with MBDs in southeastern Iran.MethodWe conducted a quasi‐experimental study involving 49 patients with CKD‐MBD in southeastern Iran in 2021. The patients were randomly assigned to either the control or intervention group. The intervention group received 12 self‐care training sessions delivered through WhatsApp, whereas the control group received routine information. We administered CKD‐MBD knowledge and behavior questionnaires of the intervention, and measured laboratory parameters before and 1 month after the intervention. The data were analyzed by SPSS15 with descriptive and analytical statistics. Pairedttest, independentt, analysis of covariance, and Mann–WhitneyUtests were using for data analysis.ResultsThe mean knowledge scores of the control group were 4.78 ± 1.78 and 6.22 ± 2.11 before and after the intervention, respectively (p = 0.200), whereas the mean knowledge scores of the intervention group were 6.08 ± 2.24 and 22.23 ± 4.55 before and after the intervention, respectively (p = 0.001). The mean behavior scores of the control and intervention groups were 75.61 ± 7.13 and 73.85 ± 7.49 before the intervention, respectively (p = 0.070), but they received the mean scores of 78.87 ± 5.58 and 82.50 ± 5.35 after the intervention, respectively (p = 0.001). The result showed a significant increase in the mean knowledge and behavior scores after the intervention. The researchers found no significant difference in the mean scores of the laboratory parameters between them before and after the intervention (p = 0.090); therefore, the intervention could not affect the laboratory parameters.ConclusionTo sum up, the study found that the training program improved the knowledge and behavior of hemodialysis patients with MBD. WhatsApp was a good and cheap way to teach them self‐care, and it helped them do it better. These results implied that this training program could help the patients have a better quality of life.
Insight on immune cells in rejection and infection postlung transplant
Authors: Liao Mingfeng , Wang Chaoxi , Zhang Mingxia , Qiao Kun 
Published: July 2023

AbstractObjectiveThe aim of this study is to provide a concise overview of the role of immune cells in rejection and infection after lung transplantation.MethodsBased on previous clinical and basic studies, the role of various types of immune cells in the development of rejection and infection after lung transplantation is summarized.ResultsImmune cell functional status is strongly associated with common complications after lung transplantation, such as primary graft dysfunction, infection and occlusive bronchitis syndrome. Targeted balancing of immune cell tolerance and rejection is an important tool for successful lung transplantation.ConclusionA comprehensive understanding of immune cell function and the mechanisms that balance immune tolerance and immune rejection may be a crucial factor in improving survival after lung transplantation.
PEI‐PLGA nanoparticles significantly enhanced the immunogenicity of IsdB137‐361 proteins from Staphylococcus aureus
Authors: Wang Beiyan , Dong Yazun , Cen Yuwei , Chen Shujie , Wen Xue , Liu Kaiyue , Wu Shuangshuang , Yu Liquan , Yu Yongzhong , Zhu Zhanbo , Ma Jinzhu , Song Baifen , Cui Yudong 
Published: July 2023

AbstractIntroductionStaphylococcus aureus seriously threatens human and animal health. IsdB137‐361 of the iron surface determinant B protein (IsdB) from S. aureus exhibits the strong immunogenicity, but its immunoprotective effect is still to be further promoted. Because PEI‐PLGA nanoparticles are generated by PEI conjugate with PLGA to develop great potential as a novel immune adjuvant, the immunogenicity of IsdB137‐361 is likely be strengthened by PEI‐PLGA.MethodsHere, PEI‐PLGA nanoparticles containing IsdB137‐361 proteins were prepared by optimizing the entrapment efficiency. Mice were immunized with IsdB137‐361‐PEI‐PLGA nanoparticles to assess their anti‐S. aureus effects. The level of IFN‐γ, IL‐4, IL‐17, and IL‐10 cytokines from spleen lymphocytes in mice and generation of the antibodies against IsdB137‐361 in serum was assessed by ELISA, the protective immune response was appraised by S. aureus challenge.ResultsIsdB137‐361 proteins loaded by PEI‐PLGA were able to stimulate effectively the proliferation of spleen lymphocytes and increase the secretion of IFN‐γ, IL‐4, IL‐17, and IL‐10 cytokine from spleen lymphocytes, and significantly enhance generation of the antibodies against IsdB137‐361 in serum, reduce the level of bacterial load in liver, spleen and kidney, and greatly improve the survival rate of mice after challenge.ConclusionThese data showed that PEI‐PLGA nanoparticles can significantly enhance the immunogenicity of IsdB137‐361 proteins, and provide an important reference for the development of novel immune adjuvant.
On the dynamic effects of the cross‐section distribution of sectoral price changes in China
Authors: Gu Biao , Fu Liying , Yu Kehuan 
Published: July 2023

AbstractThis paper investigates the dynamic interactions of the cross‐section distribution of sectoral price changes and the output growth in the Chinese economy. We compare in depth the results of Granger causality tests, Impulse Response, and Forecast Error Variance Decompositions from Mixed Sampling Frequency Vector Autoregression (MFVAR) with those from common frequency vector autoregression (VAR). It shows that potential causalities for inflation, relative price variability, relative price skewness, and output growth can be successfully detected by the MFVAR. The cross‐section distribution of sectoral price changes stands to be a fundamental determinant of fluctuations in the aggregate economy, not only in the short run but also in the long run. Moreover, the empirical results are robust to the identification restrictions imposed as well as to alternative measures for model variables. Our findings are in line with the predictions of a standard sticky‐price model, and thus pricing frictions are important factors behind the short‐run nonneutrality of nominal shocks. We highlight the primacy of the information contained in the higher‐order moments of cross‐section distribution of sectoral price changes. We propose that policy authorities should make proper use of all of the valuable information available, particularly those embodied in the distribution of sectoral prices.
Imaging inside highly scattering media using hybrid deep learning and analytical algorithm
Authors: Wiesel Ben , Arnon Shlomi 
Published: July 2023

AbstractImaging through highly scattering media is a challenging problem with numerous applications in biomedical and remote‐sensing fields. Existing methods that use analytical or deep learning tools are limited by simplified forward models or a requirement for prior physical knowledge, resulting in blurry images or a need for large training databases. To address these limitations, we propose a hybrid scheme called Hybrid‐DOT that combines analytically derived image estimates with a deep learning network. Our analysis demonstrates that Hybrid‐DOT outperforms a state‐of‐the‐art ToF‐DOT algorithm by improving the PSNR ratio by 4.6 dB and reducing the resolution by a factor of 2.5. Furthermore, when compared to a deep learning stand‐alone model, Hybrid‐DOT achieves a 0.8 dB increase in PSNR, 1.5 times the resolution, and a significant reduction in the required dataset size (factor of 1.6–3). The proposed model remains effective at higher depths, providing similar improvements for up to 160 mean‐free paths.
Association of intrinsic capacity with incidence and mortality of cardiovascular disease: Prospective study in UK Biobank
Authors: Ramírez‐Vélez Robinson , Iriarte‐Fernández Maria , Santafé Guzman , Malanda Armando , Beard John R. , Garcia‐Hermoso Antonio , Izquierdo Mikel 
Published: July 2023

AbstractBackgroundThe World Health Organization proposed the concept of intrinsic capacity (IC; the composite of all the physical and mental capacities of the individual) as central for healthy ageing. However, little research has investigated the interaction and joint associations of IC with cardiovascular disease (CVD) incidence and CVD mortality in middle‐ and older‐aged adults.MethodsUsing data from 443 130 UK Biobank participants, we analysed seven biomarkers capturing the level of functioning of five domains of IC to calculate a total IC score (ranging from 0 [better IC] to +4 points [poor IC]). Associations between IC score and incidence of six long‐term CVD conditions (hypertension, stroke/transient ischaemic attack stroke, peripheral vascular disease, atrial fibrillation/flutter, coronary artery disease and heart failure), and grouped mortality from these conditions were estimated using Cox proportional models, with a 1‐year landmark analysis to triangulate the findings.ResultsOver 10.6 years of follow‐up, CVD morbidity grouped (n = 384 380 participants for the final analytic sample) was associated with IC scores (0 to +4): mean hazard ratio (HR) [95% confidence interval, CI] 1.11 [1.08–1.14], 1.20 [1.16–1.24], 1.29 [1.23–1.36] and 1.56 [1.45–1.59] in men (C‐index = 0.68), and 1.17 [1.13–1.20], 1.30 [1.26–1.36], 1.52 [1.45–1.59] and 1.78 [1.67–1.89] in women (C‐index = 0.70). In regard to mortality, our results indicated that the higher IC score (+4 points) was associated with a significant increase in subsequent CVD mortality (mean HR [95% CI]: 2.10 [1.81–2.43] in men [C‐index = 0.75] and 2.29 [1.85–2.84] in women [C‐index = 0.78]). Results of all sensitivity analyses by full sample, sex and age categories were largely consistent independent of major confounding factors (P < 0.001).ConclusionsIC deficit score is a powerful predictor of functional trajectories and vulnerabilities of the individual in relation to CVD incidence and premature death. Monitoring an individual's IC score may provide an early‐warning system to initiate preventive efforts.
Prognostic impact of cachexia by multi‐assessment in older adults with heart failure: FRAGILE‐HF cohort study
Authors: Maekawa Emi , Noda Takumi , Maeda Daichi , Yamashita Masashi , Uchida Shota , Hamazaki Nobuaki , Nozaki Kohei , Saito Hiroshi , Saito Kazuya , Ogasahara Yuki , Konishi Masaaki , Kitai Takeshi , Iwata Kentaro , Jujo Kentaro , Wada Hiroshi , Kasai Takatoshi , Nagamatsu Hirofumi , Ozawa Tetsuya , Izawa Katsuya , Yamamoto Shuhei , Aizawa Naoki , Yonezawa Ryusuke , Oka Kazuhiro , Ako Junya , Momomura Shin‐ichi , Kagiyama Nobuyuki , Matsue Yuya , Kamiya Kentaro 
Published: July 2023

AbstractBackgroundCachexia substantially impacts the prognosis of patients with heart failure (HF); however, there is no standard method for cachexia diagnosis. This study aimed to investigate the association of Evans's criteria, consisting of multiple assessments, with the prognosis of HF in older adults.MethodsThis study is a secondary analysis of the data from the FRAGILE‐HF study, a prospective multicentre cohort study that enrolled consecutive hospitalized patients aged ≥65 years with HF. Patients were divided into two groups: the cachexia and non‐cachexia groups. Cachexia was defined according to Evans's criteria by assessing weight loss, muscle weakness, fatigue, anorexia, a decreased fat‐free mass index and an abnormal biochemical profile. The primary outcome was all‐cause mortality, as assessed in the survival analysis.ResultsCachexia was present in 35.5% of the 1306 enrolled patients (median age [inter‐quartile range], 81 [74–86] years; 57.0% male); 59.6%, 73.2%, 15.6%, 71.0%, 44.9% and 64.6% had weight loss, decreased muscle strength, a low fat‐free mass index, abnormal biochemistry, anorexia and fatigue, respectively. All‐cause mortality occurred in 270 patients (21.0%) over 2 years. The cachexia group (hazard ratio [HR], 1.494; 95% confidence interval [CI], 1.173–1.903; P = 0.001) had a higher mortality risk than the non‐cachexia group after adjusting for the severity of HF. Cardiovascular and non‐cardiovascular deaths occurred in 148 (11.3%) and 122 patients (9.3%), respectively. The adjusted HRs for cachexia in cardiovascular mortality and non‐cardiovascular mortality were 1.456 (95% CI, 1.048–2.023; P = 0.025) and 1.561 (95% CI, 1.086–2.243; P = 0.017), respectively. Among the cachexia diagnostic criteria, decreased muscle strength (HR, 1.514; 95% CI, 1.095–2.093; P = 0.012) and low fat‐free mass index (HR, 1.424; 95% CI, 1.052–1.926; P = 0.022) were significantly associated with high all‐cause mortality, but there was no significant association between weight loss alone (HR, 1.147; 95% CI, 0.895–1.471; P = 0.277) and all‐cause mortality.ConclusionsCachexia evaluated by multi‐assessment was present in one third of older adults with HF and was associated with a worse prognosis. A multimodal assessment of cachexia may be helpful for risk stratification in older patients with HF.
Differential recovery ability from infections by two blood parasite genera in males of a Mediterranean lacertid lizard after an experimental translocation
Authors: Megía‐Palma R. , Redondo L. , Blázquez‐Castro S. , Barrientos R. 
Published: July 2023

AbstractDifferent blood parasites can co‐infect natural populations of lizards. However, our knowledge of the host's ability to recover from them (i.e., significantly reduce parasitemia levels) is scarce. This has interest from an ecological immunology perspective. Herein, we investigate the host recovery ability in males of the lizard Psammodromus algirus infected by parasite genera Schellackia and Karyolysus. The role of lizard hosts is dissimilar in the life cycle of these two parasites, and thus different immune control of the infections is expected by the vertebrate host. As Schellackia performs both sexual and asexual reproduction cycles in lizards, we expect a better immune control by its vertebrate hosts. On the contrary, Karyolysus performs sexual reproductive cycles in vectors, hence we expect lower immune control by the lizards. We carried out a reciprocal translocation experiment during the lizards’ mating season to evaluate both parasitemia and leukocyte profiles in male lizards, being one of the sampling plots close to a road with moderate traffic. These circumstances provide a combination of extrinsic (environmental stress) and intrinsic factors (reproductive vs. immune trade‐offs) that may influence host's recovery ability. We recaptured 33% of the lizards, with a similar proportion in control and translocated groups. Karyolysus infected 92.3% and Schellackia 38.5% of these lizards. Hosts demonstrated ability to significantly reduce parasitemia of Schellackia but not of Karyolysus. This suggests, in line with our predictions, a differential immune relationship of lizards with these parasites, at time that supports that parasites with different phylogenetic origins should be analyzed separately in investigations of their effects on hosts. Furthermore, lizards close to the road underwent a stronger upregulation of lymphocytes and monocytes when translocated far from the road, suggesting a putative greater exposure to pathogens in the latter area.
Patient satisfaction of primary care services in Gulf Cooperation Council Countries: A scoping review
Authors: Alhenaidi Abdulaziz , Al Nadabi Waleed , Al‐Haqan Asmaa , Kelender Hisham 
Published: July 2023

AbstractPatient satisfaction (PS) is an essential element in evaluating and improving healthcare systems. Few studies have gathered evidence about patient satisfaction with primary care (PC) services in the Gulf Cooperation Council (GCC) countries. Therefore, it is important to review the existing literature examining PS with PC services in the GCC countries. This scoping review was conducted for primary data studies published between 2000 to March 2022. Out of 4461 screened articles, 37 met the inclusion criteria. Most studies were conducted in Saudi Arabia and were of cross sectional methodology. PS with primary care in the GCC is affected by multiple provider‐related and patient‐related factors and users are generally satisfied with the service provided. Future research should focus on the effects of the factors that were not explored and validate the existing results.
Study on the effect of protein lysine lactylation modification in macrophages on inhibiting periodontitis in rats
Authors: Liu Xiaochuan , Wang Jinsi , Lao Mo , Liu Fuyu , Zhu Hong , Man Kenny , Zhang Jingying 
Published: July 2023

AbstractBackgroundProtein lysine lactylation (Kla) has been proved to be closely related to inflammatory diseases, but its role in periodontitis (PD) is unclear. Therefore, this study aimed to establish the global profiling of Kla in PD models in rats.MethodsClinical periodontal samples were collected, the inflammatory state of tissues was verified by H&E staining, and lactate content was detected by a lactic acid kit. Kla levels were detected by immunohistochemistry (IHC) and Western blot. Subsequently, the rat model of PD was developed and its reliability verified by micro‐CT and H&E staining. Mass spectrometry analysis was conducted to explore the expression profile of proteins and Kla in periodontal tissues. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed, and a protein–protein interaction (PPI) network was constructed. The lactylation in RAW264.7 cells was confirmed by IHC, immunofluorescence and Western blot. The relative expression levels of inflammatory factors IL‐1β, IL‐6, TNF‐α, macrophage polarization‐related factors CD86, iNOS, Arg1, and CD206 in RAW264.7 cells were detected by real time‐quantitative polymerase chain reaction (RT‐qPCR).ResultsWe observed substantial inflammatory cell infiltration in the PD tissues, and the lactate content and lactylation levels were significantly increased. The expression profiles of protein and Kla were obtained by mass spectrometry based on the established rat model of PD. Kla was confirmed in vitro and in vivo. After inhibiting the “writer” of lactylation P300 in RAW264.7 cells, the lactylation levels decreased, and the expression of inflammatory factors IL‐1β, IL‐6, and TNF‐α increased. Meanwhile, the levels of CD86 and iNOS increased, and Arg1 and CD206 decreased.ConclusionsKla may play an important role in PD, regulating the release of inflammatory factors and polarization of macrophages.
Postharvest hexanal application delays senescence and maintains quality in persimmon fruit during low‐temperature storage
Authors: Öz Ayşe Tülin , Eryol Büşra , Ali Md. Arfan 
Published: July 2023

AbstractBACKGROUNDPersimmon (Diospyros kaki L.) fruit is characterized by rapid metabolic changes following ripening, and softening occurs due to the gradual breakdown of the cell membrane by direct catabolic cascades of phospholipase D enzyme on the phospholipid bilayer. Cell membrane weakening is also enhanced by the generation of reactive oxygen species during stress conditions such as cold storage and postharvest handling. This research evaluated the postharvest hexanal dipping application on persimmon fruit storage quality.RESULTSThe response of ‘MKÜ Harbiye’ persimmon fruit to exogenous hexanal at different concentrations (0.04% and 0.08%, named as HEX‐I and HEX‐II, respectively) on quality parameters, chilling injury (CI), microbial growth, antioxidant compounds and free radical scavenging capacity (FRSC) during storage at 0 °C and 80–90 ± 5% relative humidity for 120 days were evaluated. Both hexanal treatments retained quality and delayed senescence, as indicated by greener peel (lower a* and L* values), higher firmness, total phenol concentration, FRSC and titratable acidity, but lower weight loss, electrical conductivity, rate of CO2, ethylene production, decay and microbial growth than the control. Total soluble solids were lower in treated fruit than the control up to 100 days, and were much lower in HEX‐I treatment as compared to HEX‐II treatment. HEX‐I treatment exhibited lower CI than the other treatments during storage.CONCLUSIONHexanal at 0.04% could be used to increase the storage period of ‘MKÜ Harbiye’ persimmon fruit up to 120 days at 0 °C and 80–90 ± 5% relative humidity by retaining quality and delaying senescence. © 2023 Society of Chemical Industry.
The links between knowledge management structures and national culture: A comparative study of Apple users in Italy and Brazil
Authors: Gattermann‐Perin Marcelo , Garcia‐Perez Alexeis , Cegarra‐Leiva David , Cegarra‐Navarro Juan Gabriel 
Published: July 2023

AbstractKnowledge management structures (KMs) can be defined as structures whose purpose is to encourage people to build relationships, networks and trust. Global companies like Apple, Inc. have promoted these structures to transform its organisation into a knowledge‐based organisation. This paper identifies the role of national culture on four KMs namely open‐mindedness (OM), counter‐knowledge (CK), environmental innovation (EF) and customer capital (CC). In doing so, this study uses data collected from 354 end users of Apple (161 from Italy and 193 from Brazil). This paper provides evidence that while Apple end users from Brazil are more positively associated with higher levels of OM and CC, Italy users are more positively associated with higher levels of CK and EF. This paper discusses the role of the six dimensions of national culture–power distance, individualism, masculinity, uncertainty avoidance, long‐term orientation and indulgence of a nation that plays a significant role in how they impact the KMs. Hence, this study serves as an important contribution to global companies that are trying to develop their KMs to sustain competitive advantages.