bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular docking as a stage in the development of new drugs for veterinary use
Authors: Ponamarev V. S. 
Published: January 2023

The aim of the work is to substantiate the application of the priority use of the "molecular docking" methodology as the development of new drugs for veterinary medicine with the study of the main methodological approaches.Scientific novelty of the publication in the complex of studies of an observed study in the field of promising developments of pharmaceutical substances (including those based on digital transformation), such as the molecular docking method, with a description of the main clinical approaches and observations. The main author's hypothesis of this study is the possibility of the most promising approaches from the point of view of veterinary pharmacology for their stable possible application in industry practice.The information retrieval methodology was based on such general scientific methods of cognition as: a review of specialized search engines and databases of scientific and research data (Scopus, WoS, PubMed) over the past 15 years, analysis of the identified results, and their comparison by relevance.Molecular docking refers to modeling (including computer modeling) of molecular interaction in the context of complementarity and the search for optimal conformations to achieve the desired pharmacological effect.Molecular docking involves finding the maximum mode or mode of binding of a ligand to a target cell. The way it binds to receptors is often used and decides its state variables. They include its position in the cavity, its orientation and its conformation (torsion angles for each rotating). It is revealed that this leads to a description of the degree of freedom in a multidimensional space, their boundaries describe the degree of search.Molecular docking refers to modeling (including computer modeling) of molecular interaction in the context of complementarity and the search for optimal conformations to achieve the desired pharmacological effect.The proposed algorithms for scientific work on the consideration of applied problems of pharmacology and bioinformatics. The analyzed approach is well suited for solving the tasks.
Assessment of the ecological state of small lakes in system of the lake Velie system of the Valday National Park
Authors: Kaurova Z. G. , Glazunov A. D. 
Published: January 2023

Valdaisky National Park is a protected area located on the territory of the Novgorod region of the Russian Federation. The park was created in 1990 to preserve the natural complex of the Valdai Upland, and to organize ecological tourism on its territory.n important part of the park are water areas: within the boundaries of the park there are more than 270 lakes, the largest of which form the boundaries of the park. One of the most significant - Lake Veljo - has been the object of environmental research over the past decade. However, small lakes (Ukleinskoye and Pavlovo), which are part of the Velyo system, have not been investigated. The task of the study was to determine the ecological state of such lakes and assess their impact on the state of the lake. Vello.For the water of each studied reservoir, the main hydrochemical parameters were determined. Based on the results of the research, a water pollution index was calculated for each lake, according to the results of which they were assigned a water quality class. Both studied reservoirs belonged to the II class of quality, which characterizes them as clean. Previous studies of the Veljo waters showed the same results. Thus, on the basis of this, it can be tentatively assumed that the negative impact of the Pavlovo and Ukleinskoe lakes on the lake. Vello is missing. However, further studies of the waters of these lakes are necessary, since for many reasons the situation may change for the worse. Pollution of small lakes will also affect Veljo, which will lead to negative consequences in various industries.
Sosialisasi Aspek Perpajakan, Perhitungan Serta Metode Pelaporan Pajak Atas Pengelolaan Keuangan Desa Di Kabupaten Sidrap
Authors: Wiyana Anim , Rinaldy Syiar , Pattiware Andi , Kanji Lusiana , Ageng Prameswari Dewi 
Published: January 2023

Abstrak. Desa mempunyai sumber pendapatan berupa pendapatan asli desa, dana tersebut digunakan untuk mendanai penyelenggaraan kewenangan desa yang mencakup penyelenggaraan pemerintahan, pembangunan, pemberdayaan masyarakat, dan kemasyarakatan. Tujuan yang diharapkan dari pengabdian masyarakat ini adalah untuk memberikan pemahaman aspek pengenaan pajak yang berkaitan dengan adanya traksaksi penggunaan dana desa. Setiap transaksi ekonomi selalu dapat dikaitkan dengan aspek pengenaan pajak, baik yang dilakukan oleh pelaku usaha maupun dilakukan oleh perangkat instansi pemerintah yang dananya bersumber dari APBN / APBD. Metode pelaksanaan dilakukan dengan cara memberikan ceramah dan diskusi terhadap perwakilan perangkat desa. Pelaksanaan kegiatan Pengabdian Kepada Masyarakat ini berjalan dengan baik, para peserta sangat antusias, kegiatan ini menambah pemahaman, motivasi dan kesadaran dari peserta mengenai aspek apa saja yang dikenakan pajak dari penggunaan dana desa. Pemahaman para peserta mengenai istilah perpajakan seperti pemotongan atau pemungutan PPh 21, PPh 22, PPh 23, PPh 4 (2), PPN, serta Bea Materai. Peserta mengetahui cara perhitungan pajak, tatacara pembayaran serta pelaporan SPT secara elektronik (E-SPT).
Implementasi Teknologi Pendederan Dan Pembesaran Teripang Pasir Pada Kelompok Salterai
Authors: Tomatala Pitjont , Paulus Letsoin Petrus , Diana Rahakbauw Siska 
Published: January 2023

Teripang pasir, Holothurian scabra merupakan salah satu komuditi laut yang bernilai ekonomis penting. Teripang sering ditangkap dan dijual oleh Kelompok Salterai (Mitra) yang berada di desa Ohoitel, Kota Tual. Mitra juga memelihara (budidaya) teripang jenis ini di desa Taar yang perairannya bersifat tertutup (berteluk). Nilai manfaat yang telah dirasakan memotifasi Mitra untuk mencoba membudidayakan (Pembesaran dan Pembenihan) teripang dengan memanfaatkan kondisi perairan di desa Ohoitel yang bersifat terbuka (tidak berteluk). Keterbatasan pengetahuan mengenai teknik pembuatan wadah budidaya teripang, teknologi pendederan teripang dan manajemen usaha teripang merupakan permasalahan yang dihadapi Mitra. Kegiatan ini bertujuan untuk membantu mitra menyelesaikan permasalahan yang dihadapi. Metode yang digunakan dalam kegiatan ini yaitu penyuluhan, pelatihan dan monitoring. Dari hasil kegiatan diketahui bahwa mitra telah mempunyai ilmu dan keterampilan sehingga mereka mampu membuat wadah budidaya pembesaran dan wadah pendederan teripang dengan baik, mampu mendederkan juvenil teripang dan mitra mampu melakukan manajemen usaha teripang secara baik.
Inadequate Fixed Prosthesis Design Affecting the Periodontal Health
Authors: Iqbal Mahirah , Akhtar Shamim , Shah Farid Ullah , Ayub Nuzhat , Sartaj Khan Mohammad , Akhtar Qazi Javed 
Published: January 2023

A prerequisite for any type of restoration or replacement prosthesis is to be in harmony with the adjacent periodontal tissue and have no harmful effect on its health. Objective: To assess the effect of fixed prosthesis design on health of periodontal tissue. Methods: By using a pre-structured proforma for this observational descriptive study, during the period from September to December 2021, data were collected from sample subjects at Peshawar Dental College and Hospital, Peshawar. A total of 175 (93 females, 82 males) subjects of different ages, were selected with a pre-determined inclusion and exclusion criteria. Different variables, such as gingival index, probing pocket depth, margin location of crown / bridge and proximal contact between crown/bridge with adjacent teeth were assessed via William’s Probe. The data were analyzed with SPSS version 22. Results: All of the 175 subjects had fixed Prosthesis for 10 years or less, among these, 95 received Crown and 80 received Bridge as Fixed Prosthesis. Among these 58 % had Sub-gingivally placed crown margin, 38 % had equi-gingival, while 3 % had Supra-gingival, whereas, 57% of this prosthesis had a tight proximal contact while 42% had an open proximal contact with the adjacent tooth. 55% showed high level of severity for developing Localized periodontal issue at the site of abutment after the insertion of prosthesis, where as 44% developed localized gingivitis at the site of abutment. Conclusion: It was concluded that high score of gingival index and probing depth were recorded for subgingival finish line location and discrepancies in proximal contact points.
Effects of Combined Glucosamine/Chondroitin With Structured Physical Therapy Program On Knee Osteoarthritis: A Randomized Control Trail
Authors: Salman Muhammad , Naeem Aamer , Umar Muhammad , Asif Somiya , Haq Kiran , Saad Hasan Muhammad 
Published: January 2023

Osteoarthritis is the most debilitating condition in general population. The incidence rate of this condition is very high. Objective: this study was conducted to observe the effectiveness of glucosamine/chondroitin alone and in combination with physiotherapy on Knee osteoarthritis. Methods: A randomized control trail registered at clinicaltrials.gov under the trail no of NCT05321836. Data was collected from the Physiotherapy clinic and Neurocounsel Hospital Islamabad from 26 July 2021 to 25th March 2022. 30 participants met inclusion criteria and were randomly divided into two groups via envelop method. The experimental group was given unlabeled 1500/1200 mg of GH/CS per day for period of 6 months along with physiotherapy treatment for two months (3 sessions per week). The Control group was treated with 1500/1200 mg of unlabeled GH/CS per day for 6 months. Tools used to measure the outcome were WOMAC scale & SF-36. Measure were taken at baseline, 4th week and at 8th week. Repeated Measure ANOVA was used to analyze results at various weeks and Post Hoc analysis was opted for comparison between groups. SPSS version 21.0 was used for data analysis
Results: Means+S.D of age in experimental & control group was 64.80+9.65, 60.93+7.61respectively. Repeated measure ANOVA within both groups significant difference at various weeks of treatment as p<0.05. Between groups, Independent t’ test also revealed statistically significant difference as p-value was <0.05. Conclusion: GH/CS along with physiotherapy is very effective in reducing patient’s pain, improving functions, mobility along with quality of life as compared to GH/CS alone.
Penerapan Metode Saw Dalam Penentuan WFH Berbasis Web
Authors: Taufik Akbar Muhammad 
Published: January 2023

Bekerja dari rumah (WFH) merupakan suatu konsep yang modern dimasa pandemi saat ini dimana pegawai dapat melakukan pekerjaan nya dari rumah. (WFH) dapat membantu pegawai memberi ke seimbangan kehidupan pekerjaan pada pegawai untuk membantu perusahaan dalam menyelesaikan kerjaan mereka. Dengan bekerja jarak yg jauh atau telecommuting dapat menggambarkan bahwa karyawan akan dapat bekerjadi dari rumah (WFH).
Proses penelitian ini menggunakan sistem pendukung keputusan untuk menentukan dan memilih kinerja pegawai yang mendapatkan bonus, Proses sistem pendukung keputusan melalui kriteria dan bobot yang digunakan yaitu=Umur(0,25%),Pegawai yang mengalami covid-19(30%),Pegawai bertempat tinggal di zona waspada covid-19(20%),Pegawai yg memiliki riwayat perjalanan dari luar negri (25%)
Tujuan penulis untuk penelitian ini adalah untuk pegawai yg mendapatkan bekerja dari rumah (WFH), dengan cara menggunakan metode Simple Additive Weighting (SAW). untuk Sistem Pendukung Keputusan yang mendapatkan (WFH) terbaik. Di dalam penelitian ini cara yang kami lakukan dengan cara pengumpulan data studi kepustaka, observasi. sistem pendukung keputusan pegawai yang mendapatkan (WFH),dengan cara menggunkan metode simple additive weighting (SAW) untuk membantu pengambilan dalam menentukan keputusan pegawai yang layak mendapatkan bekerja dari rumah (WFH) terbaik.(WFH) adalah suatu kegiatan bekerja jarak jauh atau (WFH) selama pandemi covid-19 saat ini.
Pemberdayaan Melalui CSR PT TeL Pulp and Paper Bagi Kehidupan Ekonomi (Profit) Masyarakat Desa Banuayu
Authors: Cecilia Tobing  , Randi Randi , Yoyok Hendarso  
Published: January 2023

Desa Banuayu merupakan salah satu desa di wilayah Kecamatan Empat Petulai Dangku, Kabupaten Muara Enim, Provinsi Sumatera Selatan. Penilitian ini fokus kepada pemberdayaan manfaat CSR PT TeL Pulp and Paper bagi Kehidupan Ekonomi (Profit) Masyarakat Desa Banuayu. Adapun hasil penelitian yaitu program pelatihan dan pemberdayaan masyarakat; program pelatihan menjahit, program pelatihan kain jumputan, program pelatihan pembibitan karet, program bantuan peralatan untuk pelaku UMKM. Kemudian Program Kelompok Usaha Mandiri Budidaya Perikanan yaitu CSR PT TeL dan Dinas Perikanan Kabupaten Muara Enim bekerjasama untuk membantu masyarakat mengelola usaha secara mandiri. Budidaya ini berjalan sejak tahun 2015 dan bantuan yang diberikan oleh PT TeL berupa waring kolam dan perizinan wilayah seluas 8 hektar. Penelitian ini menggunakan metode penelitian kualitatif.
Garcilaso de la Vega y la tertulia napolitana del obispo "monsignor" de Catania
Authors: De la Torre Ávalos Gáldrick 
Published: January 2023

El presente artículo aborda la relación de Garcilaso con la tertulia del obispo monsignor de Catania, cuya localización se logra situar en Nápoles durante el tiempo en que residió allí el poeta de Toledo. El interés por una concepción clasicista del petrarquismo en un grupo poético del que formaron parte Bernardo Tasso, Luigi Tansillo y Antonio Sebastiano Minturno, quienes posiblemente fueron miembros destacados de la red clientelar de la marquesa de la Padula María de Cardona, sirve para contextualizar, desde un punto de vista histórico y sociológico, el contenido del soneto XXIV de Garcilaso.
Penentuan Penyedia Jasa Trucking di PT Yicheng Logistics Dengan Menggunakan Metode SAW (Simple Additive Weighting)
Authors: Yevita Nursyanti  
Published: January 2023

Permasalahan yang terjadi yaitu terdapat kerusakan barang selama pengiriman dari gudang ke pelabuhan. Hal ini membuat adanya tambahan waktu dalam pengiriman karena harus adanya retur barang kembali ke gudang untuk mengambil barang baru yang nantinya akan mengganti barang yang sudah rusak. Permasalahan ini bisa terjadi dikarenakan jasa trucking yang digunakan tidak memuat barang sesuai dengan prosedur yang ada. Jasa trucking yang digunakan oleh perusahaan ini terdapat 4 pihak. Tujuan dari penelitian ini adalah untuk memberikan usulan perbaikan dari permasalahan dalam pemilihan jasa trucking yang akan digunakan. Pemilihan jasa trucking menggunakan metode SAW (Simple Additive Weighting). Metode ini digunakan untuk mengambil suatu keputusan dimana mencari penjumlahan terbobot dari rating kinerja pada setiap alternatif pada semua atribut. Hasil dari penggunaan metode ini, maka perusahaan dapat menentukan jasa trucking mana yang paling baik dan juga perlu diprioritaskan. Usulan perbaikan lainnya yang diajukan adalah memberikan laporan harian sebagai database jasa trucking, dan pembuatan standard operating procedure dalam melakukan pemilihan jasa trucking sebagai dokumen penunjang dalam pemilihan jasa trucking. Usulan perbaikan yang diajukan ini dapat menjadi perbaikan berkelanjutan bagi PT Yicheng Logistics sehingga dapat menghindari risiko yang tidak diinginkan.
A Dilemma of Integrity in the Implementation of Conservation Development Plans in Bursa, a World Heritage Site in Turkey
Authors: Çakıcı Alp Sermin 
Published: January 2023

Conservation of historic areas defining the urban identity of the cities emerged in research on urban planning activities in Turkey only after the 1970s. However, the term ‘integrity’ was yet to be included in the national conservation legislation. In the historic city of Bursa, however, conservation decisions on the sustainability of traditional fabric had already been taken in 1960 with Piccinato’s plan. Accordingly, demolished landmark buildings in the Historic Trade Centre were reconstructed; so although authenticity was lost, the spatial integrity of the area was kept. Afterward, thirteen conservation plans for historic regions were prepared from 1981 to 2007, with the participation of experts from various institutions. The primary aims of these plans were to provide structural and spatial integrity of associated historic areas, improve living conditions, and avoid gentrification during the urban development of Bursa. However, it is impossible due to the lack of a holistic approach to the application process.
This study aims to present the dilemma observed in implementing conservation decisions taken from the 1980s until the 2000s, which pose problems regarding the integrity of the historic urban fabric in Bursa. It sets off with a brief description of the significance of integrity in urban conservation while highlighting Bursa as a pioneering city, where holistic decisions on the sustainability of its historic urban identity were taken through conservation development plans –much earlier than the rest of the country. The contradictions between conservation plans and their implemented forms are subsequently discussed to understand the level of achievement in ensuring the integrity of its urban identity. Hence, it is claimed that the traditional urban fabric of Bursa could not be preserved with its natural and architectural values since the aim of holistic conservation in related plans was implemented inconsistently.
Reusable Sanitary Pad
Authors: Dobur Ersin , Boyacı Bekir , İnceoğlu Sadiye 
Published: January 2023

Feminine hygiene products are described personal care products that are used by women to manage menstruation and to maintain menstrual health. One of the most preferred feminine hygiene products is sanitary pads. Sanitary pad is a thin pad made of absorbent material that comprises numerous layers of quilted cotton fabric or other super absorbent polymers and plastics. Soft touch, dry feel, odourless, leakproof and antibacterial properties are the expectations from a sanitary pad. Considering these expectations, in order to replace with the disposable (single use) ones we have developed a reusable sanitary pad with wings that all individual layers of fabrics are designed and produced. Drying time, pilling resistance, thermal and water vapour resistance, air permeability, dimensional stability, hydrostatic pressure, tensile strength, tear strength, phenolic yellowing, pH level, bursting strength, thickness, mass per unit area tests are carried out.
According to market outlook reports the total sales of reusable sanitary pads represent ~5%- 10% of the global health and personal care market. Disposable (single use) sanitary pads end up with landfilling and disposal by incineration and cause environmental pollution. From the perspective of woman health, equality of opportunity, sustainability and environmental health concerns it is concluded that reusable pads are a sustainable alternative for the disposable (single use) ones.
pH Measuring Pad for Underpad
Authors: Bayram Şule , Aydın Hüner 
Published: January 2023

Measuring the pH is very important to reveal the possible health problem risks of pets with early diagnosis, to enhance their quality of life and prevent negative effects on their health. However, measuring the pH level of cats and dogs urine’s is very painful and stressful process,especially during their birth duration. Accordingly, to support parents and veterinarians in this urine collection process, ‘pH Measuring pad for underpad’ project is studied. Using this ped will be quick, painless and guiding method.
In addtion to these, environmental pollution which is known by all over the world is increasing. In order to prevent this pollution, several projects has been studied in this issue and also, all raw materials have been selected as be bio-based. In this newly studies under pad project, when animal health is considered, raw materials selection is made on the basis of protecting the nature. The product which contains special indicator emphasizes the innovative aspect of the project by perforemin health checks for pets. The raw materials which use in this project is selected from having higher mechanical properties ones and also, their processability is evaluated. Formulation is obtained by mixing suitable raw materials in certain proportions.
First of all, there is a print on top of this pad. This print is made with a bio ink which includes pH indicator. By means of this ink, after the pets leave their urine on the pad, observing of color change can be possible according to the urine’s pH level. Ideally, urine’s pH value should be aroud 6.5 for cats and dogs as be considere a healthy level. IF the pH is acisic (below 5.5/6) or alkaline (above 7/7.5), there may be bacteria, crystals, an imbalnce in blood values or a sign of illness, which can have a nagative impact on pet’s health. In addtion to this, the carrier breathable film which is used in the desing of the ‘pH measuring pad for underpad’ is produced with using low density polyethylene (LDPE) obtained from renewable resoruces (green). The non-woven fabric is produced from soybean protein fibers. While, These fibers are biodegradable, soybean protein fiber or SPF, is the only renewable botanical protein fiber that can be touch today. SPF is a unique active fiber. Also it contains 16 amino acids that are healty and nourishing for the skin.
Keyword: indicator, bio, pad Giriş
Osteosarcoma tipo osteoblastoma
Authors: Alcántara Janeth Lara , Servienti Patricio , Goy Dante , Ricciardi Daniel , Carrioli Gabriel , Alessio Cristina 
Published: January 2023

El osteosarcoma es un tumor óseo que afecta comúnmente a niños, adolescentes y adultos jóvenes, con predilección por las metáfisis de huesos largos. Los pacientes se presentan con clínica de dolor en la zona afectada. El tiempo medio desde el inicio de los síntomas hasta el diagnóstico es de aproximadamente cuatro meses. Un 10 a 20 % puede presentarse con enfermedad metastásica. En la actualidad, el uso de nuevas técnicas quirúrgicas y agentes quimioterápicos, han mejorado el pronóstico de esta enfermedad.
El osteosarcoma tipo osteoblastoma es una variante de bajo grado de osteosarcoma, extremadamente rara y de difícil diagnóstico histopatológico.
IMPLEMENTASI SISTEM KEAMANAN DATA BERBASIS KRIPTOGRAFI RIVEST CODE 6, VIGENERE CHIPPER DAN KOMPRESI DATA LZW
Authors: Mubarak Roy 
Published: January 2023

Masalah keamanan data dan informasi menjadi salah satu hal yang penting di era kemajuan teknologi informasi seperti sekarang ini. Dalam pertukaran data dan informasi dibutuhkan tingkat keamanan yang tinggi, hal ini disebkan sering terjadinya pencurian data oleh pihak-pihak yang tidak bertanggung jawab. Data yang dicuri tersebut dapat dengan mudah dimanfaatkan untuk tujuan manipulasi ataupun tujuan criminal lainnya. Oleh karena itu, dibutuhkan suatu metode yang tepat untuk melindungi data tersebut, yaitu menggunakan metode kriptografi. Algoritma kriptografi terdiri atas algoritma enkripsi (E) dan algoritma dekripsi (D). Untuk lebih menjaga kemanan data atau informasi penting maka dilakukan penigkatan kemanannya dengan mengkombinasikan dua metode kriptografi dan kompresi data. Metode enkripsi Rivest Code 6 (RC6) merupakan algoritma kunci simetris yang dapat membentuk block chipper. Vigenere Cipher salah satu kriptografi klasik yang paling tangguh. Kedua metode kriptografi tersebut kemudian dikombinasikan dengan Lampel-Ziv-Welch (LZW).Kata Kunci Kriptografi, Rivest Code 5, Vigenere Cipher, Kompresi Data LZW, File