bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful living donor liver transplantation from an HIV and HCV positive donor: report from the first case in the world
Authors: Di Sandro Stefano , Catellani Barbara , Guidetti Cristiano , Magistri Paolo , Ballarin Roberto , Pecchi Annarita , Caracciolo Daniela , Guaraldi Giovanni , Guerrini Gian Piero , Di Benedetto Fabrizio 
Published: March 2023

HIV (human-immunodeficiency-virus) and HCV (hepatitis-C-virus) infections cause millions of deaths across the world every year. Since the introduction of effective therapies for HIV, in the middle of 1990s, and HCV, after 2013, those two untreatable infections became completely controlled.
Donor safety is the main goal in living donor liver transplantation (LDLT). An accurate predonation screening is mandatory for excluding risk factors related with any increase of donors’ short-term and long-term morbidity. We present the first LDLT from a donor with both HIV and HCV previous infections. Donor and recipient did not experience any complication. Individuals with well controlled HIV/HCV infections and without any risk factors may be suitable for donation of a part of their healthy liver.
Abstract video, http://links.lww.com/QAD/C833
Mechanisms of systemic low-grade inflammation in HIV patients on long-term suppressive antiretroviral therapy: the inflammasome hypothesis
Authors: Guerville Florent , Vialemaringe Marine , Cognet Celine , Duffau Pierre , Lazaro Estibaliz , Cazanave Charles , Bonnet Fabrice , Leleux Olivier , Rossignol Rodrigue , Pinson Benoît , Tumiotto Camille , Gabriel Frederic , Appay Victor , Déchanet-Merville Julie , Wittkop Linda , Faustin Benjamin , Pellegrin Isabelle 
Published: March 2023

Objective:
We aimed to determine the contribution of inflammasome activation in chronic low-grade systemic inflammation observed in patients with HIV (PWH) on long-term suppressive antiretroviral therapy (ART) and to explore mechanisms of such activation.

Design:
Forty-two PWH on long-term suppressive ART (HIV-RNA < 40 copies/ml) were compared with 10 HIV-negative healthy controls (HC).

Methods:
Inflammasome activation was measured by dosing mature interleukin (IL)-1β and IL-18 cytokines in patient serum. We explored inflammasome pathways through ex vivo stimulation of PWH primary monocytes with inflammasome activators; expression of inflammasome components by transcriptomic analysis; and metabolomics analysis of patient sera.

Results:
Median (Q1; Q3) age, ART and viral suppression duration in PWH were 54 (48; 60), 15 (9; 20) and 7.5 (5; 12) years, respectively. Higher serum IL-18 was measured in PWH than in HC (61 (42; 77) vs. 36 (27–48 pg/ml), P = 0.009); IL-1β was detected in 10/42 PWH (0.5 (0.34; 0.80) pg/ml) but not in HC. Monocytes from PWH did not produce more inflammatory cytokines in vitro, but secretion of IL-1β in response to NOD like receptor family, pyrin domain containing 3 (NLRP3) inflammasome stimulation was higher than in HC. This was not explained at the transcriptional level. We found an oxidative stress molecular profile in PWH sera.

Conclusion:
HIV infection with long-term effective ART is associated with a serum inflammatory signature, including markers of inflammasome activation, and an increased activation of monocytes upon inflammasome stimulation. Other cells should be investigated as sources of inflammatory cytokines in PWH. Oxidative stress might contribute to this chronic low-grade inflammation.
FDG PET/CT Imaging of Severe Polymyalgia Rheumatica
Authors: Chen Jeffrey , Wong Veronica Chi Ken , Bui Chuong , Mansberg Robert 
Published: March 2023

Abstract
A 68-year-old woman was referred for an 18F-FDG PET/CT for evaluation of arthralgia and raised inflammatory markers, which demonstrated intense FDG activity (SUVmax, 25.5) at numerous periarticular and extra-articular sites including the cervical and lumbar interspinous bursae, lumbar facet joints, bilateral ischial tuberosities, and greater trochanters and the aorta consistent with active polymyalgia rheumatica.
A Single-Center Case Series of Successful Abdominal Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients—Do We Need Rigorous Monitoring?
Authors: Singh Priyamvada , Von Stein Lauren , Doraiswamy Mohankumar , Samidurai Lakshmi , Singh Navdeep , Maxwell Molly , Pesavento Todd E 
Published: March 2023

Background.There is limited documentation of hematogenous transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in non–lung transplants from infected donors to uninfected recipients.Methods.We analyzed 16 recipients (7 liver, 9 kidney) transplanted from SARS-CoV-2 nucleic acid test+deceased donors from December 25, 2021, to February 28, 2022, who were followed-up for at least 90 d. Primary outcomes included coronavirus disease 2019–positivity, allograft loss, and all-cause mortality. Secondary outcomes included biopsy-proven rejection (BPAR), donor-specific antibodies, delayed graft function, and opportunistic infections. Unlike previous studies, we followed the recipients clinically with the intent to treat if they developed SARS-CoV-2 symptoms.Results.All donors were SARS-CoV-2 polymerase chain reaction–positive 72 h before donation. No recipients developed SARS-CoV-2 infection. The nadir serum creatinine and estimated glomerular filtration rate were 1.33 mg/dL and 64 mL/min/1.732 m2for kidney transplantation (KTx) respectively. The median alanine transaminase was 14.5 IU/L, aspartate aminotransferase 13 IU/L, and alkaline phosphatase 74 IU/L. Two KTx patients lost allograft, and 1 liver transplantation patient died with a failed allograft. However, this was unrelated to their SARS-CoV-2–positive donor status. One BPAR in the liver transplantation was treated with steroids. No donor-specific antibodies or BPAR were reported in the KTx. Six KTx patients experienced delayed graft function, and 4 are off dialysis. Two KTx patients developed cytomegalovirus infection because of an error in reporting the cytomegalovirus serostatus by the donor center. We did not do serial testing for SARS-CoV-2 by polymerase chain reaction, imaging, or cycle threshold score pre- or posttransplant for donor/recipient and had comparable outcomes with previous studies.Conclusions.Because of the low risk of transmission, serial testing might not be necessary and, thus, could be reciprocated at small-volume transplant centers.
Attitudes towards clinical and non-clinical services among individuals who self-harm or attempt suicide: A systematic review
Authors: Uddin Tasnim , Pitman Alexandra , Benson Gemma , Kamal Zeast , Hawton Keith , Rowe Sarah 
Published: March 2023

AbstractThe prevalence of self-harm has increased substantially in recent decades. Despite the development of guidelines for better management and prevention of self-harm, service users report that quality of care remains variable. A previous systematic review of research published to June 2006 documented largely negative experiences of clinical services among patients who self-harm. We reviewed research papers published since then until July 2022 to examine contemporary attitudes towards clinical and non-clinical services among individuals who self-harm and their relatives. We identified 29 studies meeting inclusion criteria, all of which were from high- or middle-income countries and were generally of high methodological quality. Our narrative synthesis identified negative attitudes towards clinical management and organisational barriers across services. Generally, more positive attitudes were found towards non-clinical services providing therapeutic contact, such as voluntary sector organisations and social services, than clinical services, such as emergency departments and inpatient units. Views suggested that negative experiences of service provision may perpetuate a cycle of self-harm. Our review suggests that in recent years there has been little improvement in experiences of services for patients who self-harm. These findings should be used to reform clinical guidelines and staff training across clinical services to promote patient-centred and compassionate care and deliver more effective, acceptable and accessible services.
A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes
Authors: Fernández-Moncada Ignacio , Lavanco Gianluca , Fundazuri Unai B. , Bollmohr Nasrin , Mountadem Sarah , Hachaguer Pauline , Julio-Kalajzic Francisca , Gisquet Doriane , Dalla Tor Tommaso , Serrat Roman , Bellocchio Luigi , Cannich Astrid , Fortunato-Marsol Bérénice , Nasu Yusuke , Campbell Robert E. , Drago Filippo , Cannizzaro Carla , Ferreira Guillaume , Bouzier-Sore Anne-Karine , Pellerin Luc , Bolaños Juan P. , Bonvento Gilles , Barros L. Felipe , Oliet Stephane H. R. , Panatier Aude , Marsicano Giovanni 
Published: March 2023

ABSTRACTControl of brain energy metabolism and regulation of synaptic activity through gliotransmission are two important ways, through which astrocytes contribute to mental functions. However, the potential functional and molecular links between these two astrocyte-dependent processes have been scantly explored. Here we show that a lactate-dependent shift of glycolysis underlies the production of the gliotransmitter D-serine by acute activation of astrocyte type-1 cannabinoid (CB1) receptors, thereby gating synaptic and cognitive processes. Acute cannabinoid application causes a CB1 receptor-dependent rapid and reversible increase of lactate production and release in primary astrocyte cultures. As shown before, mutant mice lacking the CB1 receptor gene in astrocytes (GFAP-CB1-KO) were impaired in a novel object recognition (NOR) memory task. This phenotype was rescued not only by the gliotransmitter D-serine, but also by its precursor L-serine. Surprisingly, the administration of lactate and of an agonist of the lactate receptor HCAR1 also reverted the memory impairment of GFAP-CB1-KO mice. This rescue effect was abolished byin vivoblockade of the astrocyte-specific phosphorylated pathway (PP), which diverts glycolysis towards L-serine synthesis, suggesting that lactate signaling might promote the accumulation of this amino acid. Consistent with this idea, lactate and HCAR1 agonism increased the co-agonist occupancy of CA1 post-synaptic hippocampal NMDA receptors. This effect of lactate was abolished by blockade of PP. By establishing a mechanistic link between lactate production and signaling, serine availability, synaptic activity and behavior, these results reveal an unforeseen functional connection between energy metabolism and gliotransmission to control cognitive processes.
Structural insights into TRPV4-Rho GTPase signaling complex function and disease
Authors: Kwon Do Hoon , Zhang Feng , McCray Brett A. , Kumar Meha , Sullivan Jeremy M. , Sumner Charlotte J. , Lee Seok-Yong 
Published: March 2023

AbstractCrosstalk between ion channels and small GTPases is critical during homeostasis and disease1, but little is known about the structural underpinnings of these interactions. TRPV4 is a polymodal, calcium-permeable cation channel that has emerged as a potential therapeutic target in multiple conditions2–5. Gain-of-function mutations also cause hereditary neuromuscular disease6–11. Here, we present cryo-EM structures of human TRPV4 in complex with RhoA in the apo, antagonist-bound closed, and agonist-bound open states. These structures reveal the mechanism of ligand-dependent TRPV4 gating. Channel activation is associated with rigid-body rotation of the intracellular ankyrin repeat domain, but state-dependent interaction with membrane-anchored RhoA constrains this movement. Notably, many residues at the TRPV4-RhoA interface are mutated in disease and perturbing this interface by introducing mutations into either TRPV4 or RhoA increases TRPV4 channel activity. Together, these results suggest that the interaction strength between TRPV4 and RhoA tunes TRPV4-mediated calcium homeostasis and actin remodeling, and that disruption of TRPV4-RhoA interactions leads to TRPV4-related neuromuscular disease, findings that will guide TRPV4 therapeutics development.
Board diversity and export intensity: the moderating role of firm size
Authors: Aksoy Mine , Yilmaz Mustafa Kemal , Canci Metin , Ay Alp 
Published: March 2023

PurposeBuilding on resource dependence theory and contingency theory (CT) and focusing on an emerging market setting, this study investigates how demographic board diversity (BD) influences the export intensity (EI) of firms listed on Borsa Istanbul (BIST), with the moderating effect of firm size, as a contingency factor, on this interaction.Design/methodology/approachUsing a sample of 65 exporting firms listed on the BIST Industrials Index, this study explores how demographic attributes of board members, represented by the board diversity index (BDI), affects EI by employing panel data analysis over the period of 2016–2020.FindingsThe results suggest that there is a negative relationship between BD and EI, but firm size has a positive moderating effect on the association of BD and EI, indicating that large firms with diverse boards are more prone to access foreign markets and make export. The findings further indicate that board size and CEO duality have a negative and significant effect on EI, while marketing intensity has a positive and significant impact.Research limitations/implicationsThe sample covers only public companies listed on the BIST Industrials Index, and the impact of board characteristics on the EI is analyzed for a limited time frame, i.e. from 2016 to 2020.Practical implicationsThe findings help business executives better understand the contribution of the firm size on the interaction of BD and EI and offers valuable insights to companies to gain a competitive edge in international markets.Originality/valueThe study provides evidence on the effects of board attributes on the EI from the perspective of emerging countries. It also helps to gain a deeper understanding of how board dynamics contribute to the internationalization of companies.
Simulation and analysis of heat transfer performance of electrical heating fabric at low temperature based on skin tissue
Authors: Li Jinyu , Yan Hangyu , Ni Yunfeng , Fu Linlin , Yang Yunchu 
Published: March 2023

PurposeAt present, electrical heating clothing is widely used to keep ourselves warm at low temperature. The purpose of this paper is to explore the heat transfer performance of electrical heating fabric and the thermal comfort of human skin at low temperature.Design/methodology/approachThe combined model of skin-electrical heating fabric system was established to simulate human skin tissue wearing electrical heating clothing. A series of simulation experiments are designed on the basis of verifying the effectiveness of the combined model. The temperature distribution inside the combined model and on the skin surface under different heating powers is simulated and analyzed. At the same time, the influence of ambient temperature on the thermal performance of electrical heating fabric was explored.FindingsThe skin model with blood vessels reflected the temperature change of human skin wearing electrical heating clothing. The higher the heating power of the electrical heating fabric was, the greater the temperature of the skin surface changed, the faster the temperature rose and the longer the time required to reach the stable state would be. After the heating element was electrified, it had the greatest effect on the average temperature of the epidermis and dermis, had smaller effect on the average temperature of subcutaneous layer and had little effect on the temperature of blood vessels. When the heating power was the same, the higher the ambient temperature was, the more obvious the heating effect of electrical heating fabric was. Electrical heating fabrics with different heating powers were suitable for different ambient temperature ranges.Originality/valueA reasonable and effective evaluation method for the thermal comfort of electrical heating fabric was provided by establishing the skin model and combined model of the skin-electrical heating fabric system. It provides a reference for the design and application of electrical heating clothing.
Supply chain transparency: theoretical perspectives for future research
Authors: Morgan Tyler R. , Gabler Colin B. , Manhart Pamela S. 
Published: March 2023

PurposeThis paper lays the groundwork for future research in supply chain transparency in two ways. First, the authors delineate the construct and explore how it is shifting the business landscape. Second, the authors connect nine theories to the construct to guide future scholars in this growing research area.Design/methodology/approachThe authors explore the practical implications for the future of supply chain transparency research through the application of nine theories: stakeholder theory; the technology acceptance model; transaction cost theory; commodity theory; competing values theory; ambidexterity; the natural-resource-based view of the firm; actor-network theory and neo-institutional theory. The authors also consider the blending of theories to provide further insights into the ways firms engage in supply chain transparency.FindingsThis analysis relates theories from several disciplines (i.e. marketing, supply chain management, economics, information systems and organizational behavior) to add theoretical insights to the concept of supply chain transparency, with suggestions for using these theories in conjunction to address complex emerging issues. The authors offer guidance and direction for cross-disciplinary research to help supply chain and logistics influence other fields.Originality/valueSupply chain transparency is a boundary-spanning phenomenon swiftly proliferating multiple aspects of business. This research applies nine theoretical perspectives to guide future researchers and lays the foundation for managers looking to adopt transparency into their supply chains.
The bubble contagion effect between crude oil and oil-exporting stock markets: the case of GCC countries
Authors: Ben Douissa Ismail , Azrak Tawfik 
Published: March 2023

PurposeThis study aims to investigate the existence of bubbles and their contagion effect in crude oil and stock markets of oil-exporting countries Gulf Cooperation Council (GCC) from 2016 to 2021.Design/methodology/approachThe authors use Generalized Sup augmented Dickey–Fuller (GSADF) and Backward Sup augmented Dickey–Fuller (BSADF) to significantly identify multiple bubbles stock and oil markets with precise dates. Furthermore, the authors check the contagion effect of bubbles between crude oil and GCC stock markets based on the time-varying Granger causality test.FindingsFirst, the authors find empirical evidence of downwards bubbles in crude oil prices and in all GCC stock indexes (except the Saudi stock index) during the corona virus disease 2019 (COVID-19) outbreak. Second, the authors do not detect empirical evidence of bubble transmission between crude oil markets and GCC stock markets (except with the Dubai Financial Market index).Practical implicationsThe findings of this study would illuminate policymakers not to limit the factors of systematic financial crises in oil-exporting countries to crude oil and to consider factors such as monetary policy and economic diversification measures. This study has also crucial implications for investors. In fact, investors should not ignore the responses of the stock markets to oil price shocks that are heterogeneous across countries when looking for investment opportunities in the GCC region.Originality/valueThe study justifies the changing nature of the bubble contagion effect through the novel implementation of the time-varying Granger causality test to detect whether bubble contagion exists between oil and GCC stock markets and if that does, in which direction.
The impacts of Sukuk on financial inclusion in selected Sukuk markets: an empirical investigation based on generalized method of moments (GMM) analysis
Authors: Khan Shabeer 
Published: March 2023

PurposeThe current developments in the Islamic capital market raise questions about its one of the main objectives of developing the Islamic capital market is to achieve financial inclusion. Despite its policy significance, the empirical literature offers little evidence of the Sukuk-financial inclusion nexus. Thus, this study aims to contribute to the literature by empirically investigating the impacts of Sukuk financing on financial inclusion in most Sukuk-issued financial markets countries.Design/methodology/approachIn this study, the author used a two-step generalized method of moments (GMM) technique to explore the impact of Sukuk financing on financial inclusion in 18 countries using data from 1995 to 2017.FindingsThe study's empirical suggest that Sukuk increases financial inclusion and supports the view that Islamic capital markets' development alleviates financing obstacles and also reflects the critical role of the Islamic capital market as a vital contributor to increasing financial inclusion.Practical implicationsThe study recommends that Sukuk could be used as a tool to tackle the issue of financial exclusion.Social implicationsThe Sukuk market development creates new job markets through innovative projects. These jobs lead to increased income for the working class, leading to higher employment and stimulating investment and financial inclusion.Originality/valueThis is one of the first studies to investigate the Sukuk-financial inclusion nexus empirically. Additionally, the study has used advanced panel techniques in the context of Sukuk and financial inclusion linkage.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-06-2022-0424
Livelihood access and challenges of coastal communities: insights from Ghana
Authors: Mohammed Asaah Sumaila , Tuokuu Francis Xavier Dery , Adda Edgar Balinia 
Published: March 2023

Purpose
The purpose of this study is to contribute to the discourse on livelihood access and challenges of fisherfolks and farmers within coastal communities in Ghana. Insights from such studies can help to create win-win outcomes between communities and oil companies and give the latter social license to operate. Also, it will help to identify the existing knowledge gaps that still need to be filled and contribute to the overall management of Ghana’s oil resources. It will further contribute to the government’s livelihood diversification programs in oil-producing communities.

Design/methodology/approach
The study employed the use of qualitative research paradigm to collect primary data in oil- and gas-producing communities in the Western Region of Ghana. Specifically, focus group discussions and in-depth interviews were conducted among diverse stakeholders.

Findings
Findings from the study show that several people and households along the coast of Ghana’s Western Region depend on the fishing industry as their livelihoods. However, fisherfolks are facing several challenges due to oil production. For instance, the quantity of fish harvest has reduced drastically since oil production started in 2010. Farming activities have also been adversely affected. The study has unearthed that the existing social and economic infrastructure are very limited to support the development of the coastal communities in Ghana’s Western Region. The study suggests that to deal with some of the challenges faced by coastal communities, livelihood diversification programs should be introduced.

Research limitations/implications
Not every community within the oil and gas areas in the Western Region was covered. Future work will address this limitation.

Practical implications
The study has revealed that the Metropolitan, Municipal and District Assemblies need to expedite the process of conducting a comprehensive needs assessment of communities and capture them in their medium-term development plans.

Social implications
The corporate social responsibility programs will create win-win outcomes between oil companies and communities.

Originality/value
The study is an original piece of work with data collected from the field. The study will contribute to the efficient management of natural resources in Ghana and other developing countries.