bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Outcomes of Total Hip Arthroplasty Using Point-of-care Manufactured Patient-specific Instruments: a Single University Hospital’s Initial Experience
Authors: Trung Hieu Pham , Quyen Nang Vo Sy , Tu Nam Vu , Trung Dung Tran , Dinh Toan Duong 
Published: June 2023

AbstractBackground 3D printed patient-specific instruments (PSI) have been recognized as a novel solution for the optimal orientation of hip implant components and were explored to improve the postoperative functional outcomes in total hip arthroplasty (THA). The manufacturing of PSI is gradually moving towards point-of-care production. This article aims to evaluate the accuracy and safety of PSI for total hip arthroplasty produced point-of-care in Vietnamese university hospital. Methods This prospective study evaluated 34 cases of THA. Preoperative 3D computed tomography (CT) scanning of the lower limb was collected to create a template for the implant size, orientation, and design of the PSI. The position of the implants and PSI design were determined directly on the software by the main surgeon. 3D-compatible resin printers were used to create the PSI in manufacturing hospital. The PSI consists of an acetabulum and a femoral component placed press-fit on the bony surface. The PSI then guided surgeons to ream the acetabulum and cut the femoral neck precisely according to the pre-planned plane. Postoperative CT scanning was obtained and superimposed onto the 3D model of the implant to evaluate the outcome. Intraoperative clinical parameters of surgical safety were also recorded. Results The preparation for PSI required an average of three days. 94% of cup size and 91% of stem size were correct. The mean values of postoperative inclination and anteversion were 44.2° ± 4.1° and 19.2° ± 5.6°, respectively. 64.7% of cases deviation from planned within ± 50range and 94.1% within ± 10° range. The means of stem anteversion, osteotomy height, and leg length discrepancy did not have a statistically significant difference between planned and achieved (p > 0.05). The average surgical time was 82.5° ± 10.8 minutes, and the intraoperative blood loss was estimated at 317.7° ± 57.6ml. 64.7% patients can walk on day of surgery. There were no complications reported. Conclusions The point-of-care manufactured PSI is a useful solution for improving the accuracy of total hip arthroplasty surgery, especially in restoring the implant orientation and reducing leg length discrepancy. However, long-term clinical follow-up evaluation is needed to confirm the efficacy and safety of this approach.
IGF2BP3 expression in pan-cancer: A bioinformatics-based study of its prognostic relevance and immunological role
Authors: Wu Yating , Wu Zhongqiu , Chen Li , Cao Yue , Niu Huimin , Lai Xiaofeng , Zhao Hu , Zhao Meng , Zhang Shenghang , Wang Shuiliang 
Published: June 2023

Abstract
Background
According to several recent studies, the m6A reader IGF2BP3 is primarily implicated in the occurrence and immunological aspects of many cancers. To obtain further insights into IGF2BP3’s role in tumor biology, we conducted a systematic analysis of publicly available databases.
Methods
Data regarding IGF2BP3 expression in various cancers were extracted from online public databases, including TIMER, GEPIA, HPA, BioGPS, and CCLE. By using the GEPIA and PrognoScan databases, we examined the association of IGF2BP3 expression in pan-cancer with patient survival. We studied the TISIDB to determine whether IGF2BP3 expression in pan-cancer correlated with immune cell infiltration. Furthermore, we assessed whether IGF2BP3 expression showed a correlation with tumor-infiltrating immune cells by referring to the TIMER database. We used R version 4.0.3 to determine the relationship between IGF2BP3 expression and the ICP genes in pan-cancer. Moreover, we used the SangerBox database to assess correlations between IGF2BP3 expression and NEO, TMB, MSI, and DNA MMR genes in human cancers. The IGF2BP3 co-expression network was examined with the LinkedOmics database.
Results
Our results demonstrated higher IGF2BP3 expression in multiple human cancers than in paired healthy tissues. IGF2BP3 expression strongly correlated with prognosis, ICP, NEO, TMB, and MSI in pan-cancer. Moreover, IGF2BP3 contributed to immune regulation and modulated the tumor microenvironment. Furthermore, the co-expression networks of IGF2BP3 mainly participated in immune regulation. The high IGF2BP3 expression group showed better treatment response to ICB in BLCA, LUAD, LGG, and PAAD.
Conclusion
Our systematic bioinformatics analysis confirmed that IGF2BP3 could function as an immunotherapeutic and prognostic biomarker in diverse human cancers. Furthermore, in future studies, it is critical to clarify the specific role of IGF2BP3 in certain cancers.
Pleasing the voters in Albania: Allowable speed limits and parking spaces increase just before elections
Authors: Pojani Dorina , Imami Drini , Lami Endrit , Zhllima Edvin 
Published: June 2023

Abstract
In Albania, just before elections, traffic and parking fines decrease in number and magnitude, as the government turns a blind eye to infractions in order to curry favour with voters and thus retain power. Once the elections are over, a period of stricter enforcement of traffic and parking rules typically ensues, and revenues from fines surge. We term this - so far unnamed – phenomenon “Electoral Mobility Management”. To provide evidence of EMM, we examine the fluctuations in revenues from traffic and parking fines issued by the state and municipal police in conjunction with national elections held between 2012 and 2021. We employ existing data collected by various institutions in Albania, which we model based on a robust econometric tool called intervention analysis. We find intermittent political interference in traffic police operations, both at the state and municipal levels. EMM is detrimental to road safety, traffic police legitimacy, and parking efficiency.
Design and application of a DFMA-based modular library of precast concrete components for assembled buildings
Authors: Dong Daode , Zou Yiquan , Pan Han 
Published: June 2023

Abstract

Assembled buildings can enable the construction industry to move in a more industrial direction. However, the design, production and installation of assembled buildings are difficult to standardise and do not meet the requirements of industrialised assembled buildings. Design for Manufacture and Assembly (DFMA), a well-established product design concept, can assist in improving this situation. This paper analyses the links between DFMA and the construction industry. The design concept of DFMA is introduced into prefabricated concrete components in assembled buildings by proposing a secondary split modularisation of prefabricated concrete components. Combining parametric design and building information modelling (BIM), a DFMA-oriented method for creating a modular library of precast concrete components is proposed. Nevertheless, the DFMA-based parametric module creation process and the system architecture and data flow in the module library are explored and developed. To enable better application of the module library, a DFMA-oriented process optimisation process for the whole assembly building process is proposed. Finally, the optimisation of the module library for the industrialised design process of assembled buildings is verified using a case study.
Improved depth residual network based tool wear prediction for cavity milling process
Authors: guan zhiwei , Cong Junyu , Wang Fei , Wang Guofeng 
Published: June 2023

Abstract
The parts with integrated design technology are widely used in aerospace field because of their advantages such as high strength and high reliability compared with riveted structures, which often present multiple cavities and thin walls, and milling occupies a large amount of machining time, while it is very easy to cause rapid degradation of tool performance because their materials are mostly made of hard-to-machine metals. To address the failure of traditional methods in monitoring the tool trajectory of complex cavity milling process, this paper proposes a tool wear prediction method based on short-time Fourier transform and improved depth residual network. Firstly, the short-time Fourier transform is used to convert the signal into a time-frequency map. Then, to solve the problem that the depth residual network describes the machining state from a single perspective, the original model is improved by adding a feature fusion layer. Finally, the signal and the time-frequency map are simultaneously input into the improved deep residual network, and the tool wear sensitive features filtered by Pearson correlation coefficient are extracted from the time domain and frequency domain of the signal, and the deep features in the time-frequency domain are extracted from the residual block structure of the time-frequency map, and the tool wear sensitive features and the deep features in the time-frequency domain are fused in the feature fusion layer to complete the model training. The experimental results show that the average prediction deviation of tool wear by the regression model established in this paper is 0.76%, which is lower than that of the original deep residual network, shallow convolutional neural network and artificial feature-based machine learning model.
A clinically relevant prognostic indicator of heart failure with mildly reduced ejection fraction is the mean velocity of the pulmonary artery
Authors: SHI YaNan , Yuan Fang , Xu Yu 
Published: June 2023

Abstract
Background
In heart failure (HF), right ventricular and pulmonary artery coupling (RV-PA) can contribute to stratification of prognosis. The non-invasive measurement of pulmonary vascular resistance (PVR) by cardiovascular magnetic resonance (CMR) has been demonstrated to be prognostic in heart failure. Prior to a significant rise in PVR, RV-PA coupling is altered in HF early. The purpose of this study was to evaluate the prognostic value of mean velocity of the pulmonary artery (mvPA) on CMR in patients with HF with mildly reduced ejection fraction (HFmrEF) and pulmonary hypertension both together and separately.
Methods
284 consecutive patients with HFmrEF were included in this retrospective study who were hospitalized and underwent CMR with measurement of RV-PA coupling parameters including mvPA between December 2017 and March 2021. We obtained a baseline data set that included clinical characteristics, laboratory results, and cardiac imaging examinations for patients with HFmrEF who underwent at least two echocardiograms performed three months apart.In order to follow up with patients, a phone interview, clinic visit, or community visit was required.The primary outcome was a composite of deaths due to all causes or rehospitalizations for heart failure.
Results
It was found that 139 patients met the primary endpoint over the mean follow-up period of 49 months. The optimal cut-off value of mvPA calculated by receiver operating curve(ROC) was 9.05cm/s for the prediction of the primary endpoint.According to Kaplan-Meier survival curves, mvPA ≤ 9.05cm/s was associated with higher mortality (Log-Rank:71.93, p < 0.001).It should be noted that mvPA maintained its prognostic value regardless of RV function or even when mortality and HF readmissions were taken into account separately.MvPA ≤ 9.05 cm/s was an independent prognostic marker, along with ischemic cardiomyopathy, hyponatremia.
Conclusions
By identifying a high-risk population of patients with preserved RV function, mvPA has confirmed its role as an early prognostic indicator. In this study, mvPA showed promise for stratifying long-term outcomes of patients with HFmrEF, and further research is required to confirm its effectiveness.
Levcromakalim Provokes a Rapid-Onset Migraine-like Phenotype Without Inducing Cortical Spreading Depolarization
Authors: Alpay Berkay , Akaydin Elif , Cimen Bariscan , Bolay Hayrunnisa , Sara Yildirim 
Published: June 2023

Abstract
Background
Migraine headache attacks and accompanying sensory augmentation can be induced by several agents including levcromakalim (LEV), that is also capable of provoking aura-like symptoms in migraineurs. We investigated whether acute LEV injection causes migraine-like phenotype in rats and induces/modulates cortical spreading depolarization (CSD), a rodent model of migraine aura.
Methods
Wistar rats were administered LEV (1mg/kg, i.p.) and compared to control (CTRL, vehicle, i.p.) and nitroglycerin (NTG, 10 mg/kg, i.p.) groups. Von Frey filaments were used to examine the periorbital and hindpaw mechanical allodynia. Dark-light box (DLB), elevated plus maze (EPM), and open field arena (OFA) were used to evaluate light sensitivity and anxiety-related behaviors. The effects of LEV on CSD parameters, somatosensory evoked potentials, and baseline dural EEG were investigated Possible CSD-induced c-fos expression was studied with Western Blot. BBB integrity in cortex is examined with Evans Blue Assay.
Results
LEV and NTG administration robustly reduced periorbital mechanical thresholds in rats and induced anxiety-like behaviors and photophobia within 30 and 120 minutes, respectively. LEV induced migraine like phenotype recovered in 2 hours while NTG group were not fully recovered before 4 hours. Both LEV and NTG did not provoke DC shift, EEG alterations or cortical c-fos expression characteristic to CSD. LEV did not affect KCl-induced CSD parameters except for an increase in propagation failure. However, NTG significantly increased both CSD susceptibility and propagation failure. Somatosensory evoked potential configurations were not altered in both LEV and NTG groups, but SSEP latencies were prolonged after CSD. Acute LEV or NTG injection did not increase cortical BBB permeability.
Conclusions
Acute systemic LEV administration induced the fastest manifestation and recovery of migraine like phenotype which was not mediated by CSD waves in the cerebral cortex. CSD modulating effects of LEV were less prominent compared to NTG, an agent without aura provoking properties. We suppose LEV triggered rapid-onset migraine-like symptoms are probably related to functional alterations in the trigeminal nociceptive system and K + channel opening properties of LEV. Understanding the neurobiological mechanisms of this nociceptive window, may provide a novel targets in migraine treatment.
Effects of thermal stress responses in goldfish (Carassius auratus): Growth performance, total carotenoids and coloration, hematology, liver histology, and critical thermal maximum
Authors: Khieokhajonkhet Anurak , Phoprakot Marisa , Aeksiri Niran , Kaneko Gen , Phromkunthong Wutiporn 
Published: June 2023

Abstract

The present study aimed to investigate the effect of thermal stress on growth, feed utilization, coloration, hematology, liver histology, and critical thermal maximum (CTmax) in goldfish (Carassius auratus) cultured at three different acclimation temperatures including 27˚C, 30˚C, and 34˚C for 10 weeks. Goldfish were assigned randomly to tanks with a quadruplicate setup, accommodating 20 fish per tank. Fish were manually fed four times a day until satiation. The result showed that fish acclimated at 34˚C exhibited suppress growth indices and significantly decreased feed utilization with linear and quadratic effects on feed efficiency ratio and protein efficiency ratio. The coloration parameter (a* value) was significantly decreased in the trunk region and total serum carotenoids at week 5, as well as a decline in L*, a*, b*values and total serum carotenoids at week 10. Total carotenoid contents in muscle and skin also decreased with increasing temperature. Aspartate aminotransferase, alanine aminotransferase, and triglycerides significantly increased with increasing temperature. However, high-density lipoprotein cholesterol decreased linearly and quadratically. Glucose and cortisol levels linearly increased with increasing temperature with a quadratic effect observed only in glucose levels. Liver histology showed swollen hepatocytes, nuclei displacement, and infiltration of inflammation in fish cultured at 34˚C. Goldfish exposed to a temperature of 34˚C displayed a higher CTmax of 43.83˚C compared to the other groups. Taken together, increasing temperature slightly improves growth (up to 30˚C) but the temperature at 34˚C significantly suppresses feed utilization, coloration as well as stress response with liver histological damage in goldfish.
A Systematic Review of the Relationship Between Muscle Oxygen Dynamics and Energy Rich Phosphates. Can NIRS help?
Authors: Maliszewski Kevin , Feldmann Andri , McCully Kevin K. , Julian Ross 
Published: June 2023

Abstract
Background: Phosphocreatine dynamics provide the gold standard evaluation of in-vivo mitochondrial function and is tightly coupled with oxygen availability. Low mitochondrial oxidative capacity has been associated with health issues and low exercise performance.
Methods: To evaluate the relationship between near-infrared spectroscopy-based muscle oxygen dynamics and magnetic resonance spectroscopy-based energy-rich phosphates, a systematic review of the literature related to muscle oxygen dynamics and energy-rich phosphates was conducted. PRISMA guidelines were followed to perform a comprehensive and systematic search of four databases on 02-11-2021 (PubMed, MEDLINE, Scopus and Web of Science). Beforehand pre-registration with the Open Science Framework was performed. Studies had to include healthy humans aged 18-55, measures related to NIRS-based muscle oxygen measures in combination with energy-rich phosphates. Exclusion criteria were clinical populations, laboratory animals, acutely injured subjects, data that only assessed oxygen dynamics or energy-rich phosphates, or grey literature. The Effective Public Health Practice Project Quality Assessment Tool was used to assess methodological quality, and data extraction was presented in a table.
Results: Out of 1483 records, 28 were eligible. All included studies were rated moderate. The studies suggest muscle oxygen dynamics could indicate energy-rich phosphates under appropriate protocol settings.
Conclusion: Arterial occlusion and exercise intensity might be important factors to control if NIRS application should be used to examine energetics. However, more research needs to be conducted without arterial occlusion and with high-intensity exercises to support the applicability of NIRS and provide an agreement level in the concurrent course of muscle oxygen kinetics and muscle energetics.
Trial Registration: https://osf.io/py32n/
Too Hot To Thrive: Community perspectives on the effect of high ambient temperature on postpartum women and neonates in Kilifi, Kenya
Authors: Lusambili Adelaide M , Khaemba Peter Wafula , Nakstad Britt , Kovats Sari , Filippi Veronique , Roos Nathalie , Part Cherie , Chersich Mathew , Luchters Stanley , Hess Jeremy , Kadio Kadiatou , Scorgie Fiona 
Published: June 2023

Abstract
Objective
To understand community perspectives on the effects of high ambient temperature on the health and wellbeing of neonates, and impacts on post-partum women and infant care in Kilifi.
Design
Qualitative study using key informant interviews, in-depth interviews and focus group discussions with pregnant and postpartum women (n = 21), mothers-in-law (n = 19), male spouses (n = 20), community health volunteers (CHVs) (n = 22) and stakeholders from health and government ministries (n = 16).
Settings
We conducted our research in Kilifi County in Kenya’s Coast Province. The area is largely rural and during summer, air temperatures can reach 37 degrees Celsius and rarely drops to 23.
Data analysis
Data were analyzed in NVivo 12, using both inductive and deductive approaches.
Results
High ambient temperature is perceived by community members to have direct and indirect pathways in pregnancy and postpartum periods, including on the neonates. The impact of direct pathways includes injuries on the neonate’s skin and in the mouth, leading to discomfort, and affecting breastfeeding and sleeping. Participants described babies as “having no peace”. These effects were perceived to be amplified by indoor smoke pollution and heat from indoor cooking fires. Community members believed that exclusive breastfeeding was not practical in conditions of extreme heat because it lowered breast milk production, which was, in turn, linked to a low scarcity of food and time spend by mothers away from their neonates performing household chores. Kangaroo Mother Care was also negatively affected. Participants reported that postpartum women took longer to heal in the heat, were exhausted most of the time and tended not to attend postnatal care.
Conclusions
There is a widespread perception that high ambient temperatures impact on postpartum women and their neonates through direct and indirect pathways. Discomfort makes it difficult for the mother to care for the baby. Multi-sectoral policies and programs are required to mitigate the negative impacts of high ambient temperatures on maternal and neonatal health in rural Kilifi and similar settings.
Vertical Transportation Lift Capacity and Operating Policy Planning for Low-Rise Buildings with Circulatory Passengers
Authors: T Godwin 
Published: June 2023

Abstract
A vertical transportation lift system in a low-rise building with three or four floors such as shopping mall has a unique characteristic where the passenger traffic is circulatory. The impact of this circulatory passenger traffic on passenger service is studied through simulation model of lift system embedded with four proactive operating strategies. The capacity of lift, the number of lifts available, and the passenger traffic level are varied in simulation experimentation to empirically and statistically analyze the impact of operating strategies on passenger waiting times and transit times. It is observed that just having the required pooled capacity for a given passenger traffic level is only a necessary condition but sufficient conditions are met by defining both the number of lifts and their capacity. It is also observed that operating strategies and passenger traffic level have an impact on passenger transit times. A prediction model derived from simulation output helps in forecasting passenger service for a given system configuration. The developed approach has potential for real world application for new lift system design and improving existing lift system operations.