bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does (re-)entering the labour market at advanced ages protect against cognitive decline? A matching difference-in-differences approach
Authors: Kim Jung Hyun , Muniz-Terrera Graciela , Leist Anja K 
Published: July 2023

BackgroundWhile prolonged labour market participation becomes increasingly important in ageing societies, evidence on the impacts of entering or exiting work beyond age 65 on cognitive functioning is scarce.MethodsWe use data from two large population-representative data sets from South Korea and the USA to investigate and compare the effects of the labour market (re-)entry and exit by matching employment and other confounder trajectories prior to the exposure. We chose the Korean Longitudinal Study of Aging (N=1872, 2006–2020) for its exceptionally active labour participation in later life and the Health and Retirement Study (N=4070, 2006–2020) for its growing inequality among US older adults in labour participation. We use the matching difference-in-differences (DID) method, which allows us to make causal claims by reducing biases through matching.ResultsWe find general positive effects of entering the labour market in South Korea (DID estimate: 0.653, 95% CI 0.167 to 1.133), while in the USA such benefit is not salient (DID estimate: 0.049, 95% CI −0.262 to 0.431). Exiting the late-life labour market leads to cognitive decline in both South Korea (DID estimate: −0.438, 95% CI −0.770 to –0.088) and the USA (DID estimate: −0.432, 95% CI −0.698 to –0.165).ConclusionsFindings suggest that Korean participants cognitively benefited from late-life labour market participation, while US participants did not. Differences in participant characteristics and reasons for labour market participation may have led to the differential findings. We found the negative effects of exiting the late-life labour force in both countries.
Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia
Authors: Samra Nadra , Jansen Nicolette S , Morani Ilham , Kakun Reli Rachel , Zaid Rinat , Paperna Tamar , Garcia-Dominguez Mario , Viner Yuri , Frankenthal Hilel , Shinwell Eric S , Portnov Igor , Bakry Doua , Shalata Adel , Shapira Rootman Mika , Kidron Dvora , Claessens Laura A , Wevers Ron A , Mandel Hanna , Vertegaal Alfred C O , Weiss Karin 
Published: July 2023

BackgroundSUMOylation involves the attachment of small ubiquitin-like modifier (SUMO) proteins to specific lysine residues on thousands of substrates with target-specific effects on protein function. Sentrin-specific proteases (SENPs) are proteins involved in the maturation and deconjugation of SUMO. Specifically, SENP7 is responsible for processing polySUMO chains on targeted substrates including the heterochromatin protein 1α (HP1α).MethodsWe performed exome sequencing and segregation studies in a family with several infants presenting with an unidentified syndrome. RNA and protein expression studies were performed in fibroblasts available from one subject.ResultsWe identified a kindred with four affected subjects presenting with a spectrum of findings including congenital arthrogryposis, no achievement of developmental milestones, early respiratory failure, neutropenia and recurrent infections. All died within four months after birth. Exome sequencing identified a homozygous stop gain variant inSENP7c.1474C>T; p.(Gln492*) as the probable aetiology. The proband’s fibroblasts demonstrated decreased mRNA expression. Protein expression studies showed significant protein dysregulation in total cell lysates and in the chromatin fraction. We found that HP1α levels as well as different histones and H3K9me3 were reduced in patient fibroblasts. These results support previous studies showing interaction between SENP7 and HP1α, and suggest loss of SENP7 leads to reduced heterochromatin condensation and subsequent aberrant gene expression.ConclusionOur results suggest a critical role for SENP7 in nervous system development, haematopoiesis and immune function in humans.
Optimal techniques of ultrasound-guided superficial and deep parasternal intercostal plane blocks: a cadaveric study
Authors: Samerchua Artid , Leurcharusmee Prangmalee , Supphapipat Kittitorn , Unchiti Kantarakorn , Lapisatepun Panuwat , Maikong Naraporn , Kantakam Perada , Navic Pagorn , Mahakkanukrauh Pasuk 
Published: July 2023

IntroductionThe optimal techniques of a parasternal intercostal plane (PIP) block to cover the T2–T6 intercostal nerves have not been elucidated. This pilot cadaveric study aims to determine the optimal injection techniques that achieve a consistent dye spread over the second to sixth intercostal spaces after both ultrasound-guided superficial and deep PIP blocks. We also investigated the presence of the transversus thoracis muscle at the first to sixth intercostal spaces and its sonographic identification agreement, as well as the location of the internal thoracic artery in relation to the lateral border of the sternum.MethodsUltrasound-guided superficial or deep PIP blocks with single, double, or triple injections were applied in 24 hemithoraces (three hemithoraces per technique). A total volume of dye for all techniques was 20 mL. On dissection, dye distribution over the first to sixth intercostal spaces, the presence of the transversus thoracis muscle at each intercostal space and the distance of the internal thoracic artery from the lateral sternal border were recorded.ResultsThe transversus thoracis muscles were consistently found at the second to sixth intercostal spaces, and the agreement between sonographic identification and the presence of the transversus thoracis muscles was >80% at the second to fifth intercostal spaces. The internal thoracic artery is located medial to the halfway between the sternal border and costochondral junction along the second to sixth intercostal spaces. Dye spread following the superficial PIP block was more localized than the deep PIP block. For both approaches, the more numbers of injections rendered a wider dye distribution. The numbers of stained intercostal spaces after superficial block at the second, fourth, and fifth intercostal spaces, and deep block at the third and fifth intercostal spaces were 5.3±1.2 and 5.7±0.6 levels, respectively.ConclusionTriple injections at the second, fourth, and fifth intercostal spaces for the superficial approach and double injections at the third and fifth intercostal spaces for the deep approach were optimal techniques of the PIP blocks.
Simulation of the AGATA spectrometer and coupling with ancillary detectors
Authors: Labiche M. , Ljungvall J. , Crespi F. C. L. , Chen S. , Bordes J. , Goasduff A. , Bottoni S. , Gamba E. , Pérez-Vidal R. M. , Bentley M. A. 
Published: July 2023

AbstractThe design study of the AGATA array began with the development of the AGATA simulation code using GEANT4. The latter played a key part in the final design of the array and provided a cost effective solution for the early development of the tracking algorithm. The code has since been maintained and developed by the collaboration to provide more realistic simulations, with reaction chambers, ancillary detectors and surrounding mechanical structures completing the entire setup.
LEAPS data strategy
Authors: Götz Andy , le Gall Erwan , Konrad Uwe , Kourousias George , Knodel Oliver , Matalgah Salman , Matilla Oscar , Spruce Darren , Orti Ana Valceril , Ounsy Majid , Rod Thomas H. , Schluenzen Frank 
Published: July 2023

AbstractThe continuous evolution of photon sources and their instrumentation enables more and new scientific endeavors at ever increasing pace. This technological evolution is accompanied by an exponential growth of data volumes of increasing complexity, which must be addressed by maximizing efficiency of scientific experiments and automation of workflows covering the entire data lifecycle, aiming to reduce data volumes while producing FAIR and open data of highest reliability. This papers briefly outlines the strategy of the league of European accelerator-based photon sources user facilities to achieve these goals collaboratively in an efficient and sustainable way which will ultimately lead to an increase in the number of publications.
A Monte Carlo study of high-LET particle production in proton boron therapy
Authors: Jacobsen Villads Lundsteen , Johansen Jacob G. , Fynbo Hans O. U. , Bassler Niels 
Published: July 2023

AbstractWe simulate the production of high-LET particles from different boron nuclear reactions in proton therapy. This study is motivated by neutron capture-enhanced particle therapy (NCEPT) (Safavi-Naeini et al. in Sci Rep 8(1):1–13, 2018) and the recently proposed proton boron capture therapy (PBCT) (Cirrone et al. in Sci Rep 8(1):1–15, 2018), where both therapy types suggest to utilize the production of high-LET particle for enhancing the RBE of the treatment. From Monte Carlo simulations performed in TOPAS (Perl et al. in Med Phys 39(11):6818–6837, 2012), we find that NCEPT reaction is the more prominent reaction of the two with a factor of $$4000 \pm 700$$

4000
±
700

more particles produced. The reason for this is the relative high fluence of thermal and epithermal neutrons (neutrons $$< 1 \hbox { keV}$$

<
1

keV

) present in clinical relevant proton fields. The creation of these neutrons is shown to be highly influenced by the target phantom and proton field size. By varying the field and phantom size, it was found that the fluence of low-energy neutrons can increase/decrease two orders of magnitude.
Uncertainty Quantification of Deep Learning–Based Statistical Downscaling of Climatic Parameters
Authors: Nourani Vahid , Khodkar Kasra , Baghanam Aida Hosseini , Kantoush Sameh Ahmed , Demir Ibrahim 
Published: July 2023

Abstract
This study investigated the uncertainty involved in statistical downscaling of hydroclimatic time series obtained by artificial neural networks (ANNs). Phase 6 of the Coupled Model Intercomparison Project (CMIP6) general circulation model (GCM) Canadian Earth System Model, version 5 (CanESM5), was used as large-scale predictor data for downscaling temperature and precipitation parameters. Two ANNs, feed forward and long short-term memory (LSTM), were utilized for statistical downscaling. To quantify the uncertainty of downscaling, prediction intervals (PIs) were estimated via the lower upper bound estimation (LUBE) method. To assess performance of proposed models in different climate regimes, data from the Tabriz and Rasht stations in Iran were employed. The calibrated models via historical GCM data were used for future projections via the high-forcing and fossil fuel–driven development scenario shared socioeconomic pathway (SSP) 5-8.5. Projections were compared with the Canadian Regional Climate Model 4 (Can-RCM4) projections via the same scenario. Results indicated that both LSTM-based point predictions and PIs are more accurate than the feedforward neural network (FFNN)-based predictions, with an average of 55% higher Nash–Sutcliffe efficiency (NSE) for point predictions and 25% lower coverage width criterion (CWC) for PIs. Projections suggested that Tabriz is going to experience a warmer climate with an increase in average temperature of 2° and 5°C for near and far futures, respectively, and a drier climate with a 20% decrease in precipitation until 2100. Future projections for the Rasht station, however, suggested a more uniform climate with less seasonal variability. Average precipitation will increase by up to 25% and 70% until near and far future periods, respectively. Ultimately, point predictions show that the average temperature in Rasht will increase by 1°C until the near future and then be a constant average temperature until the far future.

Significance Statement
The downscaling of hydroclimatic parameters is subject to uncertainty. The best way is to provide an area with the highest contingency of them as a prediction interval. The reduction width of such an interval leads to increased confidence in explaining and predicting these processes. We proposed and applied a deep learning–based machine learning method for both point prediction and prediction interval estimation of temperature and precipitation parameters for the future over two different climatic regions. The results show the superiority of such a machine learning–based prediction interval estimation for quantification of the downscaling uncertainty.
L’engagement du consommateur envers la marque : perspective socio-culturelle et voies de recherche
Authors: Scarano Monica C. , Regany Fatima , Özçağlar-Toulouse Nil 
Published: July 2023

Résumé La présente recherche met en avant les contributions de l’approche socio-culturelle à l’étude du concept de l’engagement du consommateur envers la marque (ECM). A cette fin, une analyse intégrative retrace dans un premier temps les principaux travaux portant sur l’ECM. Elle présente sa construction conceptuelle inscrite dans les paradigmes relationnel et expérientiel et fait émerger des limites de cette littérature. Dans un second temps, une lecture de l’ECM par l’approche socioculturelle permet de répondre à ces limites. Nous proposons huit voies de recherches, autour de deux approches théoriques : i) la compréhension de l’ECM au travers des ressources culturelles qui y sont investies et de ses significations à la fois identitaires, sociales et idéologiques, ii) les outils technologiques et les cadres expérientiels immersifs en tant que dispositifs socio-techniques. Des recommandations managériales sont apportées dans chacune de ces voies de recherche.
Application of ultrasound in preoperative localization diagnosis of checkrein deformity: A retrospective case series
Authors: Yuan Yu , Gao Jinmei , Jia Jun 
Published: July 2023

Background Checkrein deformity, is a rare claw toe dynamic deformity of the hallux or great toe. This study investigated the use of diagnostic ultrasound in positioning the accurate injury location causing checkrein deformity and its clinical significance for etiological diagnosis and selection of surgical methods. Methods This retrospective study included patients with confirmed checkrein deformities (according to typical symptoms) at the Department of Traumatic Orthopedics of Tianjin Hospital (Tianjin, China) from March 2017 to July 2021. Results A total of 11 patients (8 males and 3 females) with a mean age of 36.7 ± 16.8 (range 19–61) were included in this study. The injuries included six cases of tibia and fibula fracture, one case of single tibia fracture, and one case of single fibula fracture. Four patients were treated with steel plate internal fixation, three patients with intramedullary nailing, and one patient with external fixation. Three patients reported no history of any high-energy trauma or surgery. The ultrasound results showed that seven patients suffered from flexor hallucis longus (FHL) lesions, two patients suffered from flexor digitorum longus (FDL) lesions, and two patients suffered from FHL and FDL lesions. The patients underwent different surgeries tailored to their specific lesions. Toe flexion deformity was completely corrected after operation in all patients. The function of the toes was recovered to varying extent. Conclusion The results of this study demonstrates that the checkrein deformities can be confirmed by ultrasound. It could be used to determine the adhesions before the operation, acting as guidance while establishing the surgical planning.
Subacute cutaneous lupus erythematosus following ribociclib therapy for metastatic breast cancer
Authors: Collada Sánchez Victoria Lucia , Álvarez Criado Javier , Martinez Martin Virginia , Zamora Auñon Pilar , Espinosa Arranz Enrique , Mayor Ibarguren Ander , Nacher Jimenez Inmaculada , Herrero Ambrosio Alicia 
Published: July 2023

Introduction Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) has been associated with drugs with different mechanisms of action, including anti-hypertensives, tumour necrosis factor-α inhibitors and even some chemotherapy medicines. In the last years, a few reports have been described in patients treated with cyclin-dependent kinase (CDK) 4/6 inhibitors, palbociclib and abemaciclib. Case report Here, we describe a case of DI-SCLE in association with ribociclib and exemestane in a woman diagnosed with metastatic breast cancer. Management and outcome Topical mometasone was prescribed for two weeks with complete resolution of lesions, also abemaciclib was substituted for ribociclib, and the patient had stable disease with no relapse of DI-SCLE. Discussion To our knowledge, this is the first report of ribociclib-induced SCLE but based on the DI-SCLE reported cases associated others CDK4/6 inhibitors, the role of this family of drugs in dermatopathology must be further investigated.
Implementation of a Student Success Seminar and its Correlation with Resilience in Nursing Students: A Mixed-Methods Study
Authors: Huehn Susan L. , Kuehn MaryBeth , Ortiz Jenny A. , Al-Helal Rafa T. 
Published: July 2023

Aim To identify sustainable curricular practices that promote student resilience. Method Sophomore students in a four-year baccalaureate nursing program attended a positive psychology seminar and a formal mentoring program led by senior- and junior-level nursing students. Sophomore students ‘resilience was measured pre- and post-intervention using the Predictive 6-Factor Resilience Scale (PR6). Additional rich descriptions from the experience of the mentoring program were obtained in surveys from the study participants and mentors at the completion of the program. Findings Quantitative and qualitative results supported a strong increase in resilience. Conclusion and Implications for Practice Nursing schools can provide students with sustainable support that promotes resilience.
Motives for Sex and Sexual Perpetration in College Men: An Exploratory Study
Authors: Gesser N. , Eby F. G. , Anderson R. E. 
Published: July 2023

Objective Prior research has rarely focused on sexual motives (e.g., motives for having sex) when studying sexual violence perpetration prevention. The current study examined the role of sexual motives alongside other risk factors like alcohol expectancies in predicting sexual violence. Method We analyzed data from 205 male college students; 36% reported sexual perpetration of some type. Participants completed a series of questionnaires in a randomized order, including: measures of prior sexual perpetration, sexual motives, rape myth acceptance, alcohol expectancies, and a measure of social desirability. Data were analyzed using a series of T-tests and logistic regressions. Results With one exception (coping motives), all sexual motives (intimacy, enhancement, self-affirmation, peer approval, and partner approval) were endorsed at higher levels by individuals who perpetrated sexual violence than those who did not ( p < .05, Cohen’s d = .25–.56). The partner approval motive significantly predicted sexual violence perpetration on its own. The enhancement motive, both independently and in interaction with alcohol expectancies for aggression, predicted sexual violence perpetration. Two other motives, intimacy and self-affirmation, were only significant in interaction with alcohol expectancies for aggression. Conclusion All sexual motives were endorsed more frequently by those who perpetrated sexual violence than those who did not. Sexual motives had a complex interaction with alcohol expectancies in predicting sexual violence perpetration. The results suggest that intervention programs should emphasize healthy, consensual sexual relationships that do not involve alcohol.
“No Good Choice”: What are the Issues of Having no Harm Reduction Strategies in Hospitals?
Authors: Forchuk Cheryl , Serrato Jonathan , Scott Leanne , Rudnick Abraham , Dickey Chandlee , Silverman Michael 
Published: July 2023

Background: Despite an increase in methamphetamine use and subsequent hospitalizations, the majority of Canadian hospitals currently lack harm reduction strategies for substance use. This can mean that people with lived experience of methamphetamine use are faced with a number of difficult decisions to make when admitted to hospital. Caring for people with lived experience of methamphetamine use can also be problematic with zero tolerance policies requiring abstinence to be maintained. This analysis set out to understand potential health care issues due to a lack of harm reduction strategies from the prospective of people with lived experience of methamphetamine use as well as health care/service professionals. Methods: Based on a larger study, this secondary analysis explored issues discussed by people with lived experience of methamphetamine use and health care/service professionals regarding the challenges of providing harm reduction approaches in the hospital setting. A total of 108 individuals with lived experience of methamphetamine use completed a qualitative component of a mixed-method interview. In addition, 31 health care/service professionals participated in virtual focus groups and one-to-one interviews. Responses were analyzed using an ethnographic thematic approach. Results: People with lived experience of methamphetamine use reported 3 choices upon admission: leave or avoid the hospital, stay but experience unsupported withdrawal, or stay but hide their substance usage from health care professionals. Health care/service professionals described 2 options: uphold zero tolerance that can lead to stigma and a lack of knowledge regarding addiction, or accept harm reduction but be unable to implement such strategies. This could lead to health being compromised due to policy and practice that requires abstinence. Neither group of participants described a good choice for them. Conclusion: Current policy and education related to substance use needs to be revised.
Functional Outcomes, Complications, and Failure Rates in Workers’ Compensation Patients Following Hip Arthroscopic Repair: A Systematic Review
Authors: Munim Mohammed A. , Samuel Linsen T. , Rosneck James T. , Kamath Atul F. 
Published: July 2023

Background: Studies on the feasibility of hip arthroscopy in workers’ compensation (WC) patients have been largely inconsistent or limited by study design, necessitating the need for a systematic review. Purpose: We sought to systematically compare clinically significant differences between WC patients and their counterparts in relation to (1) functional outcomes, (2) complications, and (3) failure rates after hip arthroscopy. Methods: We searched MEDLINE, EMBASE, and PubMed databases for studies published between January 1996 and February 2021. In combination with “AND” or “OR” Boolean operators, the following keywords were implemented: “hip arthroscopy,” “workers’ compensation,” “outcomes,” “complications,” “revision,” and “failure rates.” Two reviewers screened eligible studies, evaluated methodological quality, and abstracted data. Results: In the 13 studies pooled, comprising 1874 patients, 276 (14.7%) patients received WC benefits. Twelve studies utilized functional outcomes, 2 studies assessed pain, and 3 studies evaluated satisfaction. Despite scoring lower in these measures preoperatively, WC patients demonstrated significant improvements after hip arthroscopy. Three studies linked compensation with marginally inferior functional scores, but this association was not significant at longer follow-up. Seven studies examined complication incidence, and 6 studies addressed failure rates, with all reporting no significant differences in rates of complications, secondary arthroscopies, or conversion to total hip arthroplasty. Conclusions: The findings of this systematic review suggest that hip arthroscopy offers clinically significant benefits, regardless of WC status. Postoperative results in WC patients, including functional scores, pain, satisfaction, complications, and failure rates, were favorable, and the degree of improvement was at least comparable with their counterparts. Further studies should consider prospective study designs with larger cohorts and extended follow-up.