bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescription of antibiotics for the prevention of failures and postoperative infections in oral implantology: a literature review
Authors: El Azrak Mohamed , Polyzois Ioannis 
Published: February 2023

The increased success and survival of dental implants reported in the literature has led them to become increasingly popular. Albrektsson estimated that more than 12 million implants are placed annually around the globe.1 A recent systematic review reported a mean survival value of 94.6% and success rates ranging from 34.9-100% over a mean follow-up period of 13 years.2 Antibiotics are a type of antimicrobial agent that kill or slow the growth of bacteria, and they are prescribed by health professionals to treat and prevent infections. Surgical antibiotic prophylaxis can be defined as “the use of antibiotics to prevent infections at the surgical site”.3 There are currently no clear guidelines on antibiotic prophylaxis for implant surgery and antibiotic prophylaxis remains a controversial topic.
To Analyze the Impact Of Formative Assessment In Fostering The Students Learning Competencies
Authors: Shameem Khursheed  , Muhammad Shahid  
Published: February 2023

The purpose of this study was to analyze the impact of formative assessment through classroom teaching and assessment experiences of teachers as well as students' learning outcomes. Education is a vibrant phases. that involves a number of interconnected teaching and learning The method can be performed without effective assessment, which is a key issue for those and serves as an essential function in teaching methodology. A particular lecturer as one of the most effective teaching strategies and practices likely used formative assessment at some point in history. As the primary characteristic of formative assessment, Socrates known as an early practitioner when preparing college students for the questions that are searched and provoked. Their responses are used to gauge their acquired knowledge and direct the instruction. A system of evaluation rewards cultural learning from teachers and students' interest. Formative assessment is utilized in Intermediate College, this qualitative and quantitative study examined that formative assessment had a positive impact on the students' learning and also teachers can review their teaching performance in the classes on the bases of student feedback. The researcher examined that although there were few weaknesses in some areas due to the lack of awareness, which can be removed by conducting a session with the teachers and students. The overall result of the report about the impact of formative assessments was on quite positive for the learning competencies of students at college.
Application of Response Surface Methodology (RSM) for Optimizing Turbidity of Paper Recycling Wastewater Using Microwave Technology
Authors: Ozkan Ugur , Bayram Okan , Göde Fethiye , Coskun Sezen , Sahin H. Turgut 
Published: February 2023

Aims: The aim of the study was to use Response Surface Methodology (RSM) to find optimal experimental design for wastewater treatments from office paper recycling. In this way, interactive effects of treatment factors were evaluated, including microwave power (MW) and durations with centrifuge time while turbidity of wastewater was chosen as the dependent output variable or an optimal response.
Methodology: The RSM approach was utilized for optimization of the process parameters and identifying the optimal conditions for the removal of turbidity in paper recycling wastewater. In this regard, a three-factor RSM were selected, using MW irradiation power (Watts), durations (seconds) and centrifuge time (min). Statistical analysis of variance (ANOVA) was carried out to identify the adequacy of the developed model. In this case, specially prepared office papers (one-side laser printed) were subjected to standard paper recycling procedure for obtaining wastewater at laboratory conditions. The experimentally derived RSM model was validated using range of statistical parameters.
Conclusions: The study revealed that under the RSM optimized conditions, a marked reduction in the turbidity of wastewater was observed for both groups studied. The R2, R2(adj) and R2(pred) values were indicates, the developed model was significant which revealed a well agreement between the experimental data and proposed model. In this approach, the R2=99.710% and lack-of-fit value were found to be 0.111 (p>0.05), which shows the model and the data consisted to each other. The lowest turbidity value was found with 150.000 Watts and 60.000 seconds in MW conditions with 15.000 minutes of centrifugation time, experimentally. With employing these variables, the turbidity value of 6.65 NTU was determined. However, the highest turbidity value of 18.013 NTU was found with MW power of 200.00 Watts with 40.000 seconds of durations and 1.591 minute of centrifugation time. It is important to note that with using optimized parameters, the turbidity value of 1.43 NTU was calculated while 1.47 NTU was found with experimentally.
Comparison of the Pathway to Hospice Enrollment Between Medicare Advantage and Traditional Medicare
Authors: Ankuda Claire K. , Belanger Emmanuelle , Bunker Jennifer , Gozalo Pedro , Keohane Laura , Meyers David , Trivedi Amal , Teno Joan M. 
Published: February 2023

ImportanceOlder adults in Medicare Advantage (MA) enroll in hospice at higher rates than those in traditional Medicare (TM), but it is unclear whether the pathway of care prior to hospice use differs between MA and TM.ObjectiveTo examine the site of care prior to hospice enrollment for MA beneficiaries compared with those in TM.Design, Setting, and ParticipantsThis population-based, retrospective cross-sectional study used Medicare claims data for decedents in calendar years 2011, 2013, 2016, and 2018 who enrolled in hospice in the last 90 days of life. Data were analyzed from February 11, 2022, to October 24, 2022.ExposuresEnrollment in MA or TM in the last month of life.Main Outcomes and MeasuresThe main outcome was the site of care prior to hospice enrollment, defined as hospital, nursing home, and home with or without home health, dichotomized as community vs hospital in a logistic regression model. Covariates included decedent demographics, hospice primary diagnosis, and county-level MA penetration. Differences in hospice length of stay between MA beneficiaries and TM beneficiaries were assessed using linear and logistic regression models.ResultsIn this study of 3 164 959 decedents, mean (SD) age was 83.1 (8.6) years, 55.8% were female, and 28.8% were enrolled in MA. Decedents in MA were more likely to enroll in hospice from a community setting than were those in TM, although the gap narrowed over time from an unadjusted 11.1% higher rate of community enrollment in MA vs TM in 2011 (50.1% vs 39.0%) to 8.1% in 2018 (46.4% vs 38.3%). In the primary adjusted analysis over the entire study period, MA enrollment was associated with an 8.09–percentage point (95% CI, 7.96-8.21 percentage points) higher rate of hospice enrollment from the community vs all other sites. This association remained in multiple sensitivity analyses to account for potential differences in the populations enrolled in MA vs TM. The mean overall hospice length of stay was 0.29 days (95% CI, 0.24-0.34 days) longer for MA decedents compared with TM decedents.Conclusions and RelevanceCompared with TM beneficiaries, those in MA were more likely to enroll in hospice from community settings vs following inpatient stays. However, hospice length of stay was not substantially different between MA and TM. Further research is needed to understand how MA plans influence hospice use and the direct association with quality of end-of-life care as reported by older adults and their families.
C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort
Authors: Tan Yi Jayne , Yong Alisa C. W. , Foo Jia Nee , Lian Michelle M. , Lim Weng Khong , Dominguez Jacqueline , Fong Zhi Hui , Narasimhalu Kaavya , Chiew Hui Jin , Ng Kok Pin , Ting Simon K. S. , Kandiah Nagaendran , Ng Adeline S. L. 
Published: February 2023

AbstractObjectiveFrontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative disorders, including behavioural variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non‐fluent variant PPA (nfvPPA). While a strong genetic component is implicated in FTD, genetic FTD in Asia is less frequently reported. We aimed to investigate the frequency of Southeast Asian FTD patients harbouring known genetic FTD variants.MethodsA total of 60 FTD‐spectrum patients (25 familial and 35 sporadic) from Singapore and the Philippines were included. All underwent next‐generation sequencing and repeat‐primed PCR for C9orf72 expansion testing. Neurofilament light chain (NfL) levels were measured in a subset of patients.ResultsOverall, 26.6% (16/60 cases) carried pathogenic or likely pathogenic variants in a FTD‐related gene, including: MAPT Gln351Arg (n = 1); GRN Cys92Ter (n = 1), Ser301Ter (n = 2), c.462 + 1G > C (n = 1); C9orf72 expansion (35–70 repeats; n = 8); TREM2 Arg47Cys (n = 1); and OPTN frameshift insertion (n = 2). Genetic mutations accounted for 48% (12/25) of patients with familial FTD, and 11.4% (4/35) of patients with sporadic FTD. C9orf72 repeat expansions were the most common genetic mutation (13.3%, 8/60), followed by GRN (6.7%, 4/60) variants. Within mutation carriers, plasma NfL was highest in a C9orf72 expansion carrier, and CSF NfL was highest in a GRN splice variant carrier.InterpretationIn our cohort, genetic mutations are present in one‐quarter of FTD‐spectrum cases, and up to half of those with family history. Our findings highlight the importance of wider implementation of genetic testing in FTD patients from Southeast Asia.
Vertically‐Stacked Discrete Plasmonic Meta‐Gratings for Broadband Space‐Variant Metasurfaces
Authors: Hassanfiroozi Amir , Yang Zih‐Syuan , Huang Shih‐Hsiu , Cheng Wen‐Hui , Shi Yuzhi , Wu Pin Chieh 
Published: February 2023

AbstractReexamining the plasmonic metasurfaces for efficient transmissive nanophotonics devices has recently drawn considerable attention. It attributes to their ease of fabrication and tunability in terms of the excitation of abundant multipoles. Despite recent efforts in developing plasmonic meta‐atoms, meta‐gratings provide an ultimate solution that enables efficient conversion of the polarization in a broadband range, particularly at optical frequencies. In this work, by vertically stacking meta‐gratings whose bandwidths overlap with each other and possess no physical limitation, plasmon mode hybridization is introduced so that highly‐transmissive broadband plasmonic metasurfaces are realized. It is reported that the intra‐coupling in a discrete plasmonic meta‐grating plays a key role in geometric phase‐controlled metasurface design. As a proof of concept, a half‐wave plate using plasmonic meta‐gratings to convert the incident circularly‐polarized light in a wavelength range from 1106 to 1521 nm with a peak efficiency of 50.2% and a gradient metasurface with truncated discrete meta‐grating as building blocks for deflecting the light with a maximum of 32.60% are demonstrated. Finally, the physical picture is explained through the electric field distributions, mode coupling, and energy splitting. The presented framework may provide an optimized way to enhance efficiency and expand the bandwidth for plasmonic systems.
Gold‐Catalyzed One‐Pot Cycloisomerization/Nucleophilic Addition/Rearrangement of Acenaphthylene Carbaldehyde Derivatives
Authors: Truchon Alexis , Dupeux Aurélien , Olivero Sandra , Michelet Véronique 
Published: February 2023

AbstractMerging the latest advances in the field of gold catalysis and the efficiency of hexafluoro‐2‐propanol (HFIP), a gold‐catalyzed orthogonal tandem reaction has been developed to access carbocyclic ketone on naphthalene substrates. The methodology involved a cycloisomerization/nucleophilic addition and a C→O rearrangement. The HFIP solvent most probably acted as a Lewis‐acid on isochromene derivatives, through hydrogen donor bond activity. A large range of acenaphthylene carbaldehyde has been engaged in this process coupling gold catalysis and Lewis‐acid behavior of HFIP leading to cyclic ketones with a yield ranging from 15 to 91% (27 compounds). The mechanism was investigated, and the reaction most presumably occurred via a classical cyclization process followed by a [Au]‐HFIP interaction for the final rearrangement. The interest of such transformation was demonstrated by performing it on a gram‐scale. Moreover, a post‐functionalization bromination was performed, as well as the isomerization of some functionalized ketones leading to full trans derivatives with a yield ranging from 78 to 90% yields.
Orbital resection by intranasal technique (ORBIT): A new classification system for reporting endoscopically resectable primary benign orbital tumors
Authors: Jafari Aria , Adappa Nithin D. , Anagnos Vincent J. , Campbell Raewyn G. , Castelnuovo Paolo , Chalian Ara , Chambers Christopher B. , Chitguppi Chandala , Dallan Iacopo , El Rassi Edward , Freitag Suzanne K. , Fernandez Miranda Juan C. , Ferreira Manuel , Gardner Paul A. , Gudis David A. , Harvey Richard J. , Huang Qian , Humphreys Ian M. , Kennedy David W. , Lee John Y. K. , Lehmann Ashton E. , Locatelli Davide , McKinney Kibwei A. , Moreau Annie , Nyquist Gurston , Palmer James N. , Prepageran Narayanan , Pribitkin Edmund A. , Rabinowitz Mindy R. , Rosen Marc R. , Sacks Raymond , Sharma Dhruv , Snyderman Carl H. , Tonya Stefko S. , Stokken Janalee K. , Wang Eric W. , Workman Alan D. , Wu Arthur W. , Yu Jen Y. , Zhang Matthew M. , Zhou Bing , Bleier Benjamin S. 
Published: February 2023

AbstractBackgroundThe Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system has become the gold standard for outcomes reporting in endoscopic orbital surgery for orbital cavernous hemangiomas (OCHs). A recent systematic review demonstrated similar outcomes between OCHs and other primary benign orbital tumors (PBOTs). Therefore, we hypothesized that a simplified and more comprehensive classification system could be developed to predict surgical outcomes of other PBOTs.MethodsPatient and tumor characteristics as well as surgical outcomes from 11 international centers were recorded. All tumors were retrospectively assigned an Orbital Resection by Intranasal Technique (ORBIT) class and stratified based on surgical approach as either exclusively endoscopic or combined (endoscopic and open). Outcomes based on approach were compared using chi‐squared or Fisher's exact tests. The Cochrane‐Armitage test for trend was used to analyze outcomes by class.ResultsFindings from 110 PBOTs from 110 patients (age 49.0 ± 15.0 years, 51.9% female) were included in the analysis. Higher ORBIT class was associated with a lower likelihood of gross total resection (GTR). GTR was more likely to be achieved when an exclusively endoscopic approach was utilized (p < 0.05). Tumors resected using a combined approach tended to be larger, to present with diplopia, and to have an immediate postoperative cranial nerve palsy (p < 0.05).ConclusionEndoscopic treatment of PBOTs is an effective approach, with favorable short‐term and long‐term postoperative outcomes as well as low rate of adverse events. The ORBIT classification system is an anatomic‐based framework that effectively facilitates high‐quality outcomes reporting for all PBOTs.
Molecular Alignment‐Induced Chemically Patchy Uniaxial Nanoparticles and Their Applications in Anti‐Counterfeiting and Self‐Assembled Superstructures
Authors: Wang Xiao , Liu Bing 
Published: February 2023

AbstractWe report an unusual strategy for synthesizing patchy nanoparticles (NPs) by controlling the orientation of the molecules that form the NPs. This is realized by synchronous polymerization and crystallization of liquid crystal (LC) monomers during scalable precipitation polymerization. The resulting NPs are cylinders with highly uniform shapes and have only a single LC domain. The patchy properties originate from the discrepancy of surface chemical compositions on flat and side surfaces and can be switched on and off by solvent. Extra colloidal blocks can be grown onto the patches, resulting in highly uniform triblock patchy dumbbells, which have integrated optical properties, and as demonstrated, show triple‐mode optical authentication in anti‐counterfeiting labels or patterns. We also demonstrate that the triblock patchy cylinders are attractive building blocks for long LC rods or porous colloidal materials through polymerization‐induced self‐assembly.
A Diode‐Like Dye‐Cu Anisotropic Junction in a Coordination Polymer as a Logic State Ratchet for Intratumor Redox Photomodulation
Authors: Shi Yusheng , Wang Peiyuan , Li Mochen , Zhang Tiexin , Han Gang , Duan Chunying 
Published: February 2023

AbstractRedox logic materials offer new avenues to modulate intracellular pathologic redox environment area‐specifically, but the unambiguity of redox logic states and their unidirectional and repetitive switchability are challenging to realize. By merging a bistable diisophthalic phenazine dye ligand with CuIIsalt, a multistable coordination polymer (CP) was constructed, of which the dye‐Cu anisotropic junction achieved the diode‐like unidirectional electron transfer and logic state ratchet for the first time. Radical cationic CP maintainedOFFstatus with low toxicity in healthy tissues, but was reduced to the neutralSERVOstate by the overexpressed glutathione (GSH) in hypoxic tumors. After photoirradiation, the stabilized charge‐separatedONstatus promoted photo‐Fenton reaction for reactive oxygen species (ROS) signal transduction, and simultaneously recovered the initial state for catalytic signal amplification of ROS, furnishing intratumor redox photomodulation for therapy.
Double Deprotonation of CH3CN by an Iron‐Aluminium Complex**
Authors: Stadler Benedek , Gorgas Nikolaus , White Andrew J. P. , Crimmin Mark R. 
Published: February 2023

AbstractHerein we present the first double deprotonation of acetonitrile (CH3CN) using two equivalents of a bimetallic iron‐aluminium complex. The products of this reaction contain an exceeding simple yet rare [CHCN]2− dianion moiety that bridges two metal fragments. DFT calculations suggest that the bonding to the metal centres occurs through heavily polarised covalent interactions. Mechanistic studies reveal the intermediacy of a monomeric [CH2CN]− complex, which has been characterised in situ. Our findings provide an important example in which a bimetallic metal complex achieves a new type of reactivity not previously encountered with monometallic counterparts.[1, 2] The isolation of a [CHCN]2− dianion through simple deprotonation of CH3CN also offers the possibility of establishing a broader chemistry of this motif.
Cas9‐orthologue‐mediated cytosine and adenine base editors recognizing NNAAAA PAM sequences
Authors: Li Min , Zhao Yuting , Xue Xiaowen , Zhong Jingli , Lin Jianxiang , Zhou Jiankui , Yu Wenhua , Chen Jun , Qiao Yunbo 
Published: February 2023

AbstractCRISPR/Cas9 system has been applied as an effective genome‐targeting technology. By fusing deaminases with Cas9 nickase (nCas9), various cytosine and adenine base editors (CBEs and ABEs) have been successfully developed that can efficiently induce nucleotide conversions and install pathogenic single nucleotide variants (SNVs) in cultured cells and animal models. However, the applications of BEs are frequently limited by the specific protospacer adjacent motif (PAM) sequences and protein sizes. To expand the toolbox for BEs that can recognize novel PAM sequences, we cloned a Cas9 ortholog from Streptococcus sinensis (named as SsiCas9) with a smaller size and constructed it into APOBEC1‐ or APOBEC3A‐composed CBEs and TadA or TadA*‐composed ABEs, which yield high editing efficiencies, low off‐targeting activities, and low indel rates in human cells. Compared to PAMless SpRY Cas9‐composed BE4max, SsiCas9‐mediated BE4max displayed higher editing efficiencies for targets with “NNAAAA” PAM sequences. Moreover, SsiCas9‐mediated BE4max induced highly efficient C‐to‐T conversions in the mouse Ar gene (R841C) to introduce a human androgen resistance syndrome‐related mutation (AR R820C) in early mouse embryos. Thus, we developed novel BEs mediated by SsiCas9, expanded the toolbox for base conversions, and broadened the range of editable genomes in vitro and in vivo.
Coevolving stability and activity of LsCR by a single point mutation and constructing neat substrate bioreaction system
Authors: Liu Hua‐Tao , Weng Chun‐Yue , Zhou Lei , Xu Hao‐Bo , Liao Zhen‐Yu , Hong Han‐Yue , Ye Yuan‐Fan , Li Shu‐Fang , Wang Ya‐Jun , Zheng Yu‐Guo 
Published: February 2023

AbstractCarbonyl reductase (CR)‐catalyzed bioreduction in the organic phase and the neat substrate reaction system is a lasting challenge, placing higher requirements on the performance of enzymes. Protein engineering is an effective method to enhance the properties of enzymes for industrial applications. In the present work, a single point mutation E145A on our previously constructed CR mutant LsCRM3, coevolved thermostability, and activity. Compared with LsCRM3, the catalytic efficiency kcat/KM of LsCRM3‐E145A (LsCRM4) was increased from 6.6 to 21.9 s−1 mM−1. Moreover, E145A prolonged the half‐life t1/2 at 40°C from 4.1 to 117 h, was increased by 5°C, was increased by 14.6°C, and Topt was increased by 15°C. Only 1 g/L of lyophilized Escherichia coli cells expressing LsCRM4 completely reduced up to 600 g/L 2‐chloro‐1‐(3,4‐difluorophenyl)ethanone (CFPO) within 13 h at 45°C, yielding the corresponding (1S)‐2‐chloro‐1‐(3,4‐difluorophenyl)ethanol ((S)‐CFPL) in 99.5% eeP, with a space‐time yield of 1.0 kg/L d, the substrate to catalyst ratios (S/C) of 600 g/g. Compared with LsCRM3, the substrate loading was increased by 50%, with the S/C increased by 14 times. Compared with LsCRWT, the substrate loading was increased by 6.5 times. In contrast, LsCRM4 completely converted 600 g/L CFPO within 12 h in the neat substrate bioreaction system.
Fusion Enzymes Involved in Biosynthetic Tailoring Reactions in Fungi
Authors: Liang Jia‐jing , Li Hang 
Published: February 2023

AbstractEnzyme fusion, the fusion of enzymes with different domains to a single protein, has been widely recognized as a promising strategy in the development of biocatalysts. Nature has evolved gene fusion to combine different catalytic enzymes to function as a fusion enzyme, and this strategy is utilized in many natural product biosynthetic pathways. Owing to rapid advances in genome sequencing and biosynthetic pathway characterization, there is increasing interest in fusion enzymes from fungal biosynthetic pathways, particularly those involved in tailoring steps. This concept aims to provide an up‐to‐date overview of fusion enzymes that catalyze tailoring reactions in the biosynthesis of fungal secondary metabolites. Since fungal fusion enzymes are often associated with novel metabolites, this pioneering work may stimulate the exploration of the structural diversity of fungal natural products through genome mining of the untapped biosynthetic pathways involving fusion enzymes.