bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram for predicting axillary upstaging in clinical node-negative breast cancer patients receiving neoadjuvant chemotherapy
Authors: Maimaitiaili Amina , Chen Heyan , Xie Peiling , Liu Zhenzhen , Ling Rui , Zhao Yi , Yang Hongjian , Liu Yunjiang , Liu Ke , Zhang Jianguo , Mao Dahua , Yu Zhigang , Liu Yinhua , Fu Peifen , Wang Jiandong , Jiang Hongchuan , Zhao Zuowei , Tian Xingsong , Cao Zhongwei , Wu Kejin , Song Ailin , Jin Feng , He Jianjun , Fan Zhimin , Zhang Huimin 
Published: March 2023

Abstract

Purpose The prediction of axillary lymph node status after neoadjuvant chemotherapy (NAC) becoming critical because of the advocation of the de-escalation of axillary management. We investigate associated factors of axillary upstaging in clinical node-negative(cN0) breast cancer patients receiving NAC to develop and validate an accurate prediction nomogram; Methods We retrospectively analyzed 2101 breast cancer patients with stage of cT1-3N0 treated by NAC and subsequent surgery between 2010 and 2020 in twenty hospitals across China. Patients randomly divided into a training set and validation set (3:1). Univariate and multivariate logistic regression analysis were performed, after which a nomogram was constructed and validated; Results In total, pathologic node negativity (ypN0) achieved in 1552 (73.9%) patients and another 549(26.1%) patients upstaged to pathologic node positive (ypN+). Breast pathologic complete response (bpCR) was achieved in 499 (23.8%) patients and non-bpCR in 1602 (76.3%) patients. A nomogram was established by ER, tumor histology, NAC regimen, cycle of NAC treatment, and the bpCR, which were confirmed by multivariate logistic analysis as independent predictors of nodal upstaging in the training cohort (n = 1576). The area under the receiver operating characteristic curve (AUC) of the training cohort and validation cohort were 0.74 (95%CI, 0.64–0.71) and 0.76 (95% CI, 0.63–0.75) respectively; Conclusion We present a nomogram with a nationwide large sample data which can effectively predict axillary upstaging after neoadjuvant chemotherapy to give better advice for individualized axillary lymph node management of breast cancer.
Intuitionistic Type-2 Fuzzy Soft Set based Decision Support Framework for Emergency Relief Supply Chain Planning
Authors: Dan Surajit , Roy Bikash Koli , Kar Samarjit , Biswas Sanjib , Castillo Oscar , Pal Tandra 
Published: March 2023

Abstract
Hybrid uncertainty based models are more useful than the individual components. Earlier soft sets and intuitionistic fuzzy sets were combined to form intuitionistic fuzzy soft sets (IFSS) which are rich potentials for solving decision-making problems. Dan et al. (2020) introduced the concept of an intuitionistic type 2 fuzzy set (IT2FS), which is a direct extension of the intuitionistic fuzzy set. In this paper, using the concept of soft sets over the intuitionistic type-2 fuzzy sets, we define a new hybrid set and named it as Intuitionistic type-2 fuzzy soft sets (IT2FSS). After defining the set we present the set-theoretic operations such as complement, union, intersection over these sets and mention some algebraic properties with examples of these sets. After that, we define the level sets over IT2FSS and represent two decision-making algorithms based on level sets. We put forth definitions for score and accuracy functions and rules for the comparison of a group of IT2FSS. We carry out a IT2FSS based investigation to find out the key success factors for effective Humanitarian Supply Chain Management (HSCM) in emergency relief operations. We observe that supply chain financing, collaboration and coordination, and public governance are the three critical factors as opined by the experts for effective HSCM.
Polydatin Radiosensitizes Lung Cancer while Preventing Radiation Injuries by Modulating Tumor-infiltrating B Cells
Authors: Guo Jiaming , Ding Wen , Cai Shanlin , Ren Pan , Chen Fengxu , Wang Jiawen , Fang Kai , Li Bailong , Cai Jianming 
Published: March 2023

Abstract
Background: Acquired radioresistanceand the undesired normal tissue radiation injuriesseriously discount the therapeutic effect of lung cancer radiotherapy. In this study, we aimed to explore the role and potential mechanism of polydatin in simultaneously decreasing radioresistance and radiation injuries.
Methods: The tumor-bearing model of nude mice were used to investigate the tumor inhibition of polydatin on lung cancer and its effect on radiosensitivity, and the effect of polydatin on B cell infiltration in cancerous tissue was investigated. In addition, we performed systemic radiotherapy on BABL/ C mice and evaluated the protective effect of polydatin on radiation injury by the Kaplan-meier survival curve. Moreover, the regulation of polydatin on proliferation and apoptosis of A549 cells was also investigated in vitro.
Results: In this study, it is firstly found that polydatin inhibits the growth and promotes the radiosensitivity of lung cancer while reducing the radiation damage of the healthy tissue. Further, it is evidenced that the major mechanism relies on its regulation on body’s immune function, and in particular, the inhibition of radiation-induced B cell infiltration in tumor tissue.
Conclusion: These findings show that in addition to tumor inhibition, polydatin also promotes the sensitivity and reduces the adverse reactions of radiotherapy, making itself a promising candidate for boosting lung cancer radiotherapy efficacy.
Elevated serum soluble CD27 levels are associated with both disease activity and humoral immune activity in patients with rheumatoid arthritis
Authors: Shi Lianjie , Yang Ju , Xu Jing , Dai Juhua , Li Jiangtao 
Published: March 2023

Abstract
Objective: To investigate the serum level of soluble CD27 (sCD27) and its potential clinical significance in rheumatoid arthritis (RA).
Methods: The serum sCD27 levels in both RA and health controls (HCs) were detected by enzyme-linked immunosorbent assay. The medical information and laboratory data of the patients were collected. The serum sCD27 levels in RA with different clinical features were analyzed, and the correlation between the clinical data and serum sCD27 levels were also analyzed. Independent samples t test, Mann-Whitney U-test or Wilcoxon signed-rank test, Spearman correlation were used for statistical analysis.
Results: The levels of sCD27 were elevated in the RA patients (5647 ± 6526 pg/mL) than those of HCs (1659 ± 648 pg/mL) (P < 0.001). In addition, serum sCD27 levels were correlated with age, erythrocyte sedimentation rate, C-reactive protein (CRP), rheumatoid factor (RF), immunoglobulin A, immunoglobulin G, Complement 4 and disease activity score in 28 joints in RA patients. The levels of sCD27 were higher in the RF-positive RA patients (6522 ± 7447 pg/mL) than the RF-negative patients (3902 ± 2098 pg/mL), and the similar finding was also observed in anti-cyclic citrullinated peptide (anti-CCP) antibody positive (6241 ± 7207 pg/mL) and anti-CCP negative RA patients (4183 ± 2187 pg/mL). The RA patients with increased sCD27 and increased CRP showed the highest ratio of osteoporosis complication (P < 0.001).
Conclusion: Serum sCD27 might be a promising biomarker which could reflect both disease activity and humoral immunity activity in RA.
Automated Detection of Biases using MapReduce Framework with Class Imbalance Approach on Healthcare Dataset
Authors: Prakhar Jyoti , Haider Md. Tanwir Uddin 
Published: March 2023

Abstract
In today’s scenario, artificial intelligence (AI) systems and machine learning (ML) algorithms are being used for simple and complex decision-making processes in various fields like healthcare systems, education, recruitment process, banking, and other areas. But the dataset on which the AI or ML systems work may be biased due to which proper decisions process can’t be done especially in the case of the health care system. Thus, the detection of biases is a very important step for the betterment of the model. Previously the detection of biases is being done manually with the help of static methods which was not perfect. Sometimes it gives errors in the detection of biases when it actually is not and due to the manual process, it also takes much time to detect the biases. Seeing this fact, in this paper we propose a novel framework and also implemented it to detect biases automatically in a big dataset of the healthcare system without using any statistical methods or any performance metrics. This model uses the MapReduce framework and class imbalance approach to measure the unbalancing in the dataset. With the help of the MapReduce framework, we categorize the particular protected attribute, not the whole dataset afterward we find the disorder due to the protected attribute and if a disorder exists, we apply the class imbalance approach to detect the biases within the dataset. The implementation shows that the result of this framework outperforms as compared with other techniques.
Evaluation of levosimendan as treatment option in preterm infants with cardiac dysfunction and pulmonary hypertension
Authors: Schroeder Lukas , Holcher Stanley , Leyens Judith , Geipel Annegret , Strizek Brigitte , Dresbach Till , Mueller Andreas , Kipfmueller Florian 
Published: March 2023

Abstract
Objectives

Levosimendan as a calcium-sensitizer is a promising innovative therapeutical option for the treatment of severe cardiac dysfunction (CD) and pulmonary hypertension (PH) in preterm infants, but no data are available analyzing levosimendan in cohorts of preterm infants.

Design/ Setting

Retrospective single-center cohort study.

Patients and Methods

Retrospective single-center cohort study. Data of all preterm infants (gestational age (GA) <37 weeks) with levosimendan treatment and CD and/or PH in the echocardiographic assessment between 01/2018 and 06/2021 were screened for analysis.

Main outcome measures

The primary clinical endpoint was defined as echocardiographic response to levosimendan.

Results

105 preterm infants were finally enrolled for further analysis. 48% of the preterm infants were classified as extremely low for GA newborns (ELGANs, <28 weeks of GA) and 73% as extremely low birth weight infants (<1500g, ELBW). The primary endpoint was reached in 71%, without difference regarding GA or BW. The incidence of moderate or severe PH decreased from baseline to follow-up (24h) in about 30%, with a significant decrease in the Responder-group (p<0.001). The incidence of left-ventricular dysfunction and bi-ventricular dysfunction decreased significantly from baseline to follow-up (24h) in the Responder-group (p=0.007, and p<0.001, respectively). The arterial lactate level decreased significantly from baseline (4.7 mmol/l) to 12h (3.6 mmol/l, p<0.05), and 24h (3.1 mmol/l, p<0.01).

Conclusion

Levosimendan treatment is associated with an improvement of both CD and PH in preterm infants, with a stabilization of the MAP during the treatment and a significant decrease of arterial lactate levels. Future prospective trials are highly warranted.
Community evaluation of the physical and insecticidal durability of DuraNet® Plus, an alpha-cypermethrin and piperonyl butoxide incorporated mosquito net: protocol for a multi-country study in West, Central and East Africa
Authors: Agbevo Abel , Ahogni Idelphonse , Menze Benjamin , Tungu Patrick , Kemibala Elison E. , Govoetchan Renaud , Wondji Charles , Padonou Germain Gil , Ngufor Corine 
Published: March 2023

Abstract
Background Pyrethroid-PBO nets have demonstrated improved impact against clinical malaria transmitted by pyrethroid resistant mosquito vectors and are being scaled up across Africa. However very little is known about their physical and insecticidal durability under operational conditions. This study will investigate the attrition, fabric integrity, insecticide content and bioefficacy of DuraNet® Plus, a new WHO prequalified alphacypermethrin and PBO incorporated net developed by Shobikaa Impex Private Limited over 3 years of field use in communities in Benin, Cameroon and Tanzania. Methods The study will be conducted in parallel in selected villages in Zakpota District in Benin, Mbalmayo, District in Cameroon and Muheza District in Tanzania. In each country, ~ 1800 households will be recruited and randomised to receive DuraNet® Plus or DuraNet® (a WHO prequalified alphacypermethrin-only ITN). Follow up surveys will be performed at 1 month post distribution to investigate adverse events and subsequently every 6–12 months to assess ITN attrition and fabric integrity following standard WHO procedures. A second cohort of nets will be withdrawn every 6–12 months and assessed for alpha-cypermethrin and PBO content and for entomological activity in laboratory bioassays (cone bioassays and tunnel tests). Alpha-cypermethrin bioefficacy will be monitored using the susceptible Anopheles gambiae Kisumu strain in cone bioassays while PBO bioefficacy will be monitored using pyrethroid resistant strains with overexpressed P450 enzymes in tunnel tests to determine the proportion of efficacious nets (≥ 95% knockdown, ≥ 80% mortality or ≥ 90% blood feeding inhibition in tunnels) at each time point. Nets withdrawn at 12, 24 and 36 months from each country will also be tested in experimental hut trials against wild free-flying pyrethroid resistant Anopheles gambiae sl in Côvè Benin to investigate the superiority of DuraNet® Plus over DuraNet® at each time point under semi field conditions. Conclusion This large-scale multi country trial will provide useful information on the durability of a pyrethroid-PBO net (DuraNet® Plus) in 3 different regions in sub-Saharan Africa. The methods proposed for bioefficacy testing could also contribute towards the development of new standardised guidelines for monitoring the insecticidal efficacy of pyrethroid-PBO nets under operational conditions.
Biological Resistance of Coppiced and Non-Coppiced Rosewood (Pterocarpus Erinaceus Poir.) in the Field and Their Technological Performance
Authors: ANTHONIO Frederick Amin , ANTWI-BOASIAKO Charles 
Published: March 2023

Abstract

Rosewood (Pterocarpus erinaceus) timber is highly sought-after for furniture and building purposes due to its qualitative properties including durability. It coppices easily, which offers an essential strategy in curbing timber over-exploitation towards sustainable management. Mass loss, together with visual durability rating, was adopted in assessing the natural durability within the coppiced rosewood. Mass loss increased (i.e., durability decreased) up the coppiced (4.96±0 - 40±0.9%) and non-coppiced boles (2.9±0.06 - 15±0%), being greater for the coppiced trees (4.96± 0 - 40±0.9%) than the non-coppiced (2.9 ±0.06 - 15±0%) and for sapwoods [i.e., 26±0.3 - 40±0.9% (coppiced) and 14±0.03 - 15±0% (non-coppiced)] than the heartwoods [i.e., 4.96±0 - 5.3±0% (coppiced) and 2.9±0.06 - 5±0.07% (non-coppiced)] of both trees.The differences were significant (p˂0.05). Heartwoods and sapwoods along the boles of each tree type would be rated very durable (0-5%) and moderately durable (11-40%) respectively. Due to their great durability, both wood types would be widely suitable for several engineering applications. Thus, promotion of the coppicedP. erinaceuswood production would supplement the use of its non-coppiced counterpart to increase the wood market base.
Study on transient characteristics of secondary arc of AC/DC hybrid transmission lines on the same tower
Authors: Yang LIU , Baina HE , Yunwei ZHAO , Fantao MENG , Shuo WU , Weihan DAI , Yuanlong WEI , Shuo WANG , Dongjin ZHANG 
Published: March 2023

Abstract
The AC/DC hybrid transmission line is affected by electromagnetic coupling. After the line is failed, the secondary arc is difficult to extinguish, which posed a serious threat to the stable and reliable operation of the line. Taking a 500kV AC double-circuit and ± 800kV Yun-Guang UHV DC transmission line on the same tower as an example, this paper is built an AC/DC hybrid transmission line model through PSCAD, studied the influence of coupling section length and fault point location on the transient characteristics of the secondary arc, and analyzed the suppression effect of the DC line coupling operation mode on the secondary arc. The results is showed that the secondary arc current of AC and DC lines is greatly affected by the length and fault location of the coupling section. The AC line fault is located at the midpoint of the coupling section. When the length of the coupling section is 400m, the amplitude of the secondary arc current is reached the minimum value; When the DC line fault is located at the midpoint of the coupling section, the amplitude of the secondary arc current is reached the maximum value. In addition, the bipolar coupling operation mode of DC lines can effectively limit the amplitude of secondary arc current and recovery voltage of AC and DC lines, and the suppression effect of secondary arc is obvious.
Risk of in-hospital deterioration for children with single ventricle physiology
Authors: Foote Henry P , Lee Grace S , Gonzalez Carla Dominguez , Shaikh Zohaib , Ratliff William , Gao Michael , Hintze Bradley , Sendak Mark , Jackson Kimberly W , Kumar Karan R , Li Jennifer S , McCrary Andrew W 
Published: March 2023

Abstract
Children with single ventricle physiology (SV) are at high risk of in-hospital morbidity and mortality. Identifying children at risk for deterioration may allow for earlier escalation of care and subsequently decreased mortality. We conducted a retrospective chart review of all admissions to the pediatric cardiology non-ICU service from 2014–2018 for children < 18 years old. We defined clinical deterioration as unplanned transfer to the ICU or inpatient mortality. We selected children with SV by diagnosis codes and defined infants as children < 1 year old. We compared demographic, vital sign, and lab values between infants with and without a deterioration event. We evaluated vital sign and medical therapy changes before deterioration events. Among infants with SV (129 deterioration events over 225 admissions, overall 25% with hypoplastic left heart syndrome), those who deteriorated were younger (p = 0.001), had lower baseline oxygen saturation (p = 0.022), and higher baseline respiratory rate (p = 0.022), heart rate (p = 0.023), and hematocrit (p = 0.008). Median Duke Pediatric Early Warning Score increased prior to deterioration (p < 0.001). Deterioration was associated with administration of additional oxygen support (p = 0.012), a fluid bolus (p < 0.001), antibiotics (p < 0.001), vasopressor support (p = 0.009), and red blood cell transfusion (p < 0.001). Infants with SV are at high risk for deterioration. Integrating baseline and dynamic patient data from the electronic health record to identify the highest risk patients may allow for earlier detection and intervention to prevent clinical deterioration.
Altered resting-state functional connectivity and its association with executive function in adolescents with borderline personality disorder
Authors: Yi Xiaoping , Wang Xueying , Fu Yan , Jiang Furong , Zhang Zhejia , Wang Jing , Han Zaide , Xiao Qian , Chen Bihong T. 
Published: March 2023

Abstract
Background: Adolescents with borderline personality disorder (BPD) may have impaired executive functions such as impulse control and inattention. There are few functional MRI (fMRI) studies in adolescents with BPD and the neuroimaging markers of this disorder are unknown. The aim of this study was to investigate the functional connectivity (FC) of BPD in adolescents, and to explore the relationship between FC changes and executive function in adolescents with BPD.
Methods: 50 adolescents aged 12 to 17 years with BPD and 21 gender-and-age matched healthy controls (HC) were enrolled into the study. Brain MRI scan including a 3D-T1 weighted structural sequence and a resting-state fMRI was acquired. A seed-based FC analysis was performed. We used the Stroop color-word test (SCWT) and the trail making test (TMT) to evaluate the executive function of the participants. Correlative[xy1] [肖2] analysis of FC alterations with executive function and clinical symptoms were also performed.
Results: Compared to the HCs, adolescents with BPD showed increased FC in the limbic - cortical circuit, such as the FC between the left hippocampus and right parahippocampal gyrus, between the right middle occipital gyrus and the left middle temporal gyrus, and between the left medial superior frontal gyrus and the right inferior temporal gyrus. FC in the default mode network (DMN) was decreased between the left angular gyrus and the left precuneus but increased between the left angular gyrus and the right anterior cingulate cortex (voxel P < 0.001, cluster P < 0.05, FWE corrected). The BPD group demonstrated significantly lower cognitive testing scores than the HC group on the SCWT-A (P＜0.001), SCWT-B (P＜0.001), and SCWT-C (P =0.034). The FC alterations between limbic system and cortical regions were associated with SCWT and TMT (P < 0.05).
Conclusions: FC alterations were noted in both limbic - cortical circuit and DMN in adolescents with BPD, which were associated with impaired executive function. This study implicated the FC alterations being the neural correlates of executive functioning in adolescents with BPD.
Growing gender disparity in HIV infection in Africa: sources and policy implications
Authors: Ratmann Oliver , Monod Mélodie , Brizzi Andrea , Galiwango Ronald , Ssekubugu Robert , Chen Yu , Xi Xiaoyue , Kankaka Edward , Ssempijja Victor , Abeler-Dörner Lucie , Akullian Adam , Blenkinsop Alexandra , Bonsall David , Chang Larry , Shozen Dan , Fraser Christophe , Golubchik Tanya , Gray Ronald , Hall Matthew , Jackson Jade , Kigozi Godfrey , Laeyendecker Oliver , Mills Lisa , Quinn Thomas , Reynolds Steven , Santelli John , Sewankambo Nelson K. , Spencer Simon , Ssekasanvu Joseph , Thomson Laura , Wawer Maria , Serwadda David , Godfrey-Faussett Peter , Kagaayi Kagaayi Joseph , Grabowski M Kate M Kate 
Published: March 2023

Abstract
HIV incidence in eastern and southern Africa has historically been concentrated among girls and women aged 15-24 years, but as new cases decline with
HIV interventions, population-level infection dynamics may shift by age and gender. Here, we integrated population-based surveillance and longitudinal deep- sequence viral phylogenetics to assess how HIV incidence and the population groups driving transmission have evolved over a 15-year period from 2003 to 2018 in Uganda. HIV viral suppression increased more rapidly in women than men, resulting in 1.5-2 fold higher suppression rates in women with HIV by 2018 across age groups. Incidence declined more slowly in women than men, increasing pre-existing gender imbalance in HIV burden. Age-specific transmission flows shifted; the share of transmission to girls and women aged 15-24 years from older men declined by approximately one third, whereas the contribution of transmission to women aged 25-34 years from men aged 0-6 years older doubled from 2003 to 2018. We estimated closing the gender gap in viral sup- pression could have reduced HIV incidence in women by half in 2018 and ended gender disparities in incidence. This study suggests that male-targeted HIV pro- grams to increase HIV suppression are critical to reduce incidence in women, close gender gaps in infection burden and improve men’s health in Africa.