bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Dual-polarimetric QPE relations based on Disdrometer measurements in Metro Manila, Philippines
Authors: Ibanez Marco Polo Agudal , Martirez Samuel , Pura Alvin Galdo , Sajulga Ramjun , Cayanan Esperanza , Chang Wei-Yu , Jou Ben Jong-Dao 
Published: June 2023

AbstractQuantitative precipitation estimates (QPE) can be further improved using estimation algorithms derived from localized raindrop size distribution (DSD) observations. In this study, DSD measurements from two disdrometer stations within Metro Manila during the Southwest monsoon (SWM) period were used to investigate the microphysical properties of rainfall and develop localize dual-polarimetric relations for different radar bands and rainfall types. Observations show that the DSD in Metro Manila is more distributed to larger diameters compared to Southern Luzon and neighboring countries in the Western Pacific. This is reflected by the relatively higher mass-weighted mean diameter (Dm) and smaller shape (μ) and slope (Λ) parameters measured in the region. The average values ofDmand normalized intercept parameter (Nw) in convective rain samples also suggest that convective rains in Metro Manila are highly influenced by both continental and oceanic convective processes. Dual-polarimetric variables simulated using the T-matrix scattering method showed good agreement with disdrometer-derived reflectivity (ZH) values. The 0.5 dB and 0.3° km-1thresholds for the differential reflectivity (ZDR)and specific differential phase (KDP) based on the blended algorithm of Cifelli et al. (2011) and Thompson et al. (2017) are proven to be useful since the utility of the dual-polarimetric variables as rainfall estimators are shown to have dependencies on the radar band and rainfall type. Evaluation of the QPE products with respect to the C-band shows thatR (KDP, ZDR) has the best performance among the dual-pol relations and statistically outperformed the conventional Marshall & Palmer relation [R(ZMP)]. The results show that dual-polarimetric variables such as ZDRand KDPcan better represent the DSD properties compared to one-dimensionalZ, hence providing more accurate QPE products than the conventionalR(Z) relations.
Amplification of Future Warming Trends due to Feedbacks between Adaptation and Mitigation
Authors: Xu Yangyang , Ramanathan Veerabhadran 
Published: June 2023

Abstract
Inclusion of human behavioral changes and societal response as explicit feedback terms is now at the forefront of climate projections. We adopt an integrated socio–energy–ecological–climate model, ISEEC, to quantify the role of feedbacks between warming, mitigation, and adaptation on future warming. The model explicitly allows for two-way natural-social system interactions. Here we address the energy needs for climate adaptation by the most vulnerable population numbering in the billions, an issue overlooked by most if not all climate change studies. Through formulations based on the empirical literature, we quantitatively demonstrate that a widening economic gap, the struggle of the most vulnerable segment of society to adapt to climate change, and the lack of just transition to clean energy sources, can all lead to a substantial increase in primary energy generation, CO2 emissions and an additional warming of 0.5-2ºC, through a cascade of amplifying feedbacks. The behavioral transformation of the top billion in providing clean energy technology to the bottom (poorest) billions emerges as a major factor in breaking the adaptation-mitigation feedback loop.
Polymerizing actin regulates myosin-independent mechanosensing by modulating actin elasticity and flow fluctuation
Authors: Mittal Nikhil , Michels Etienne , Pakenas Kathleen , Royer Shaina , Han Sangyoon 
Published: June 2023

Abstract
The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions. However, it has been unclear if the stiffness-dependent differential tension is induced solely by myosin activity. Here, we report that in the absence of myosin contractility, 3T3 fibroblasts still transmit stiffness-dependent differential levels of traction. This myosin-independent differential traction is regulated by polymerizing actin assisted by actin nucleators Arp2/3 and formin where formin has stronger contribution than Arp2/3. Interestingly, we report a four-fold reduction in traction of cells when both Arp2/3 and myosin were inhibited, compared to cells with only myosin inhibition, while there was only a slight reduction in F-actin flow speed in those cells. We show that the conventional rigid-actin-based clutch model is insufficient to explain this force-flow behavior and requires the inclusion of F-actin’s own elasticity into consideration. Our model prediction suggests that Arp2/3 and formin modulate stiffness sensing via stiffening F-actin network with stronger effect from formin. Analysis of F-actin flow reveals stiffness-dependent fluctuation frequency in the flow speed, which is predictable only via the model considering actin elasticity. Our data and model provide a potential role of the polymerizing actin and its elasticity in myosin-independent mechanosensing.
What is behind water users’ satisfaction? An empirical analysis of Water Users Associations under different water availability conditions
Authors: Bopp Carlos , Engler Alejandra , Jordán Cristian , Jara-Rojas Roberto 
Published: June 2023

Abstract
The level of satisfaction within a community sharing a common pool resource is essential to strengthening collective actions. In the case of irrigation water, which is becoming a critical resource due to its declining availability, the satisfaction level of the farmers that join community-based water management organizations called Water User Associations may be a relevant factor explaining individuals' cooperation and collective actions. Using a sample of 393 users we performed confirmatory factor analysis, correlational analyses, and multilevel regressions. A composite indicator of user satisfaction showed significant correlations with the positive evaluation of the association staff performance, the effectiveness of monitoring and enforcement, and the confidence that other users do not withdraw more water than they are allocated. Additionally, we found that satisfaction levels for users facing higher and lower water scarcity conditions and found that satisfaction is significantly higher in the latter case. User satisfaction is affected by several structural characteristics of the water channel, users' human and social capital variables. Our study contributes to the existing literature on common resource management in irrigated areas by identifying significant factors of user satisfaction in WUAs under different water availability conditions, which can be used as inputs to improve water governance policies because, ultimately, it is users who determine cooperation rates and willingness to participate in associations collective actions.
Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness
Authors: Wang Ciyang , Western Dan , Yang Chengran , Ali Muhammad , Wang Lihua , Gorijala Priyanka , Timsina Jigyasha , Ruiz Agustín , Pastor Pau , Fernandez Maria , Panyard Daniel , Engelman Corinne , Deming Yuetiva , Boada Merce , Cano Amanda , García-González Pablo , Graff-Radford Neill , Mori Hiroshi , Lee Jae-Hong , Perrin Richard , Sung Yun Ju , (DIAN) Dominantly Inherited Alzheimer Network , (ADNI) Alzheimer’s Disease Neuroimaging Initiative , Cruchaga Carlos 
Published: June 2023

Abstract

Brain metabolism perturbation can contribute to traits and diseases. We conducted the first large-scale CSF and brain genome-wide association studies, which identified 219 independent associations (59.8% novel) for 144 CSF metabolites and 36 independent associations (55.6% novel) for 34 brain metabolites. Most of the novel signals (97.7% and 70.0% in CSF and brain) were tissue specific. We also integrated MWAS-FUSION approaches with Mendelian Randomization and colocalization to identify causal metabolites for 27 brain and human wellness phenotypes and identified eight metabolites to be causal for eight traits (11 relationships). Low mannose level was causal to bipolar disorder and as dietary supplement it may provide therapeutic benefits. Low galactosylglycerol level was found causal to Parkinson’s Disease (PD). Our study expanded the knowledge of MQTL in central nervous system, provided insights into human wellness, and successfully demonstrates the utility of combined statistical approaches to inform interventions.
Characteristics and influencing factors of soil microbial functional diversity in Shushan urban forest, Southeast China
Authors: Wang Mimi , Liu Haiyang , Li Gang , XU Bojing , Xu Xiaoniu 
Published: June 2023

Abstract
The study of soil microbial functional diversity and its influencing factors in urban forests can provide important insights into maintaining a healthy material cycle within these ecosystems. In this study, we selected three plantation forests, including Pinus massoniana Lamb (PM), Quercus acutissima Carruth (QA), Liquidambar formosana Hance (LF), and secondary deciduous broadleaved forest (DB). We studied the metabolic characteristics of soil microbial carbon sources in the four kinds of forest vegetation in the growing season and dormant season and the 0-10cm, 10-20cm, 20-30cm soil layer, three soil layers (0-10, 10-20, 20-30cm) using the Biolog-ECO microplate method. Our study suggested that soil microorganisms with PM showed the lowest metabolic activity. Soil microorganisms in the four forest vegetation had the lowest carbon source utilization capacity for monosaccharide/ glycoside/ polymercan, and the highest utilization capacity for amines. The Shanon-Wiener (H′) and Simpson (D) diversity indices of the four kinds of forest vegetation were significantly different from 0-10cm in the soil layer, and the H′ and D values of LF were higher than PM, QA and DB. Soil pH and total phosphorus (TP) are closely related to the microbial functional diversity and carbon source utilization of the four vegetation.
Microalbumin and Diabetes mellitus type 2(T2DM): A Mendelian Randomization Study
Authors: Lu Hao , Cao Yu , Duan Pengqian , Wu Yanhui 
Published: June 2023

Abstract
Background
The observational link between microalbumin and type 2 diabetes (T2DM) is well established. However, it is uncertain if the link is causative.
Methods
The current study performed Mendelian randomization (MR) on publicly accessible genome-wide association study (GWAS) summary data in order to investigate the causal linkages between microalbumin and T2DM. A single set of MR analyses was performed. As instrumental variables, a dataset of single nucleotide polymorphisms (SNPs) with significance value smaller than the genome-wide criteria (5*10 − 8) was employed.
Results
The results suggested that microalbumin had a causal influence on T2DM risk based on the 0.05 threshold. Microalbumin was shown to be positively linked with the risk of T2DM using the inverse variance weighted (IVW) technique (OR = 1.346, 95% CI, 1.062–1.706, P = 0.014). The weighted median MR estimations revealed that microalbumin was positively associated with the incidence of T2DM (OR = 1.356, 95% CI, 1.038–1.771, P = 0.0254).
Conclusions
The data showed that microalbumin may increase the incidence of T2DM dependent on the genome-wide statistical significance level. This study supports the notion that microalbumin has a negative causal influence on T2DM risk.
Trial registration
retrospectively registered.
Palm Petiole Inspired Nonlinear Anti-Vibration Ring with Deformable Crescent-shaped Cross-section
Authors: Feng Xiao , Feng Jian , An Ertai , Wang Hailin , Wu Shuanglong , Qi Long 
Published: June 2023

Abstract
This paper presents a novel nonlinear anti-vibration ring with deformable crescent-shaped cross-sections (NAVR-DCCS) inspired by the petiole of palm leaf. The proposed NAVR-DCCS exhibits markedly enhanced nonlinear quasi-zero stiffness through deformable cross-sections, which endow it with advantageous vibration isolation attributes. A comprehensive investigation of the structural nonlinearities and dynamic behaviors of the NAVR-DCCS is undertaken, with emphasis on the principle of cross-sectional deformation and its nonlinear stiffness properties. This study explores the influence of pertinent parameters on the nonlinear characteristics and displacement transmissibility. Tensile-compression testing and transmissibility measurements are conducted to verify theoretical calculations, and the experimental results are found to be in congruity with theoretical predictions. The beneficial nonlinear characteristics of the NAVR-DCCS hold promise for providing a passive vibration isolation methodology, representing a potentially innovative solution with broad-reaching applicability and utility across diverse research domains.
Flexible control of vocal timing in bats enables escape from acoustic interference
Authors: Clemens Jan , Kössl Manfred , Poeppel David , Hechavarría Julio , Kiai Ava 
Published: June 2023

Abstract
In natural environments, background noise can degrade the integrity of acoustic signals, posing a problem for animals that rely on their vocalizations for communication and navigation. A simple behavioral strategy to combat acoustic interference would be to restrict call emissions to periods of low-amplitude or no noise. Using audio playback and computational tools for the automated detection of over 2.5 million vocalizations from groups of freely vocalizing bats, we show that bats (Carollia perspicillata) can dynamically adapt the timing of their calls to avoid acoustic jamming in both predictably and unpredictably patterned noise. This study demonstrates that bats spontaneously seek out temporal windows of opportunity for vocalizing in acoustically crowded environments, providing a mechanism for efficient echolocation and communication in cluttered acoustic landscapes.
A new species, new combination, and a nomen novum in the genus Trechispora from India
Authors: Krishnapriya K , T.K. Arun Kumar 
Published: June 2023

Abstract
The genus Trechispora accommodate species with corticioid, clavarioid, and polyporoid basidiomata, smooth to verrucose, angular basidiospores, monomitic or dimitic hyphal systems with clamp-connections, and ampullaceous septa. During a study of clavarioid fungi of Kerala, seven Trechispora species with clavarioid basidiomata were collected and studied. Morphological and molecular analyses revealed one species, T. cystidiata, characterized by cystidia, to be new to science. In addition, a new combination (T. angulispora) and a nomen novum (T. corneri) are also proposed. Descriptions of all the species collected and studied from Kerala, along with their phylogenetic placement in the order Trechisporales is presented. A taxonomic key to the clavarioid species of Trechisporales from India is also provided.
Pre-treatment re-bleeding following aneurysmal subarachnoid hemorrhage: a systematic review of prediction models
Authors: Dissanayake Arosha S , Ho Kwok M , Phillips Timothy J , Honeybul Stephen , Hankey Graeme J 
Published: June 2023

Abstract
Pre-treatment rebleeding following aneurysmal subarachnoid hemorrhage (aSAH) increases the risk of a poor outcome. Treatment as early as practicable is recommend to mitigate this risk though the benefit of emergency treatment is debated, emphasising the need for individualised risk prediction. Predictive models have been recently described incorporating established risk factors. Following prospective registration on the International prospective register of systematic reviews (PROSPERO) CRD 42023421235; Ovid Medline (Pubmed), Embase and Googlescholar were searched for English language studies describing clinical prediction models between May 2002 and May 2023 for pre-treatment rebleed prediction following aSAH in adults ³18 years. Of 763 unique records, 17 full texts were scrutinised with 5 publications describing 4 models reviewed. The Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS) checklist and the Prediction model Risk Of Bias ASsessment Tool (PROBAST) were used. Reported performance varied from 0.790 to 0.939. The Intracranial Aneurysm Risk Score demonstrated a high risk of bias and low clinical applicability. The risk score of Oppong et al. was not validated or calibrated and the Clinical + Morphological model of Liu et al. did not have a sufficient event-to-predictor ratio. The ARISE extended model was formulated using patient data from multiple centres and time periods increasing the risk of non-standardised predictor assessment. Furthermore, patient recruitment overlapped the period of the endovascular paradigm shift in aneurysm treatment, limiting the applicability of this model to patients treated according to modern conditions. Thus, no published predictive model could be recommended for clinical use.
Unusual ocular and renal phenotype of MELAS syndrome with maculopathy associated with focal and segmental glomerulosclerosis.
Authors: Ordoñez Katherine Peña , Morillo Salvador García , Naranjo Paola Donoso , Bermejo María Mantrana , Domínguez José Luis , Valdivia Miguel Ángel Pérez 
Published: June 2023

Abstract
Background: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited genetic mitochondrial disorder.
Case presentation: We present the clinical case of a 28-year-old woman with nephrotic proteinuria and vision loss. Bilateral macular oedema and drusen-like deposits were observed in the funduscopic examination and coincided with the first episode. She presented with renal function deterioration. Furthermore, the renal biopsy revealed focal and segmental glomerulosclerosis. The genetic study was negative, and complete sequencing of mitochondrial DNA was requested. The results indicated, 45% heteroplasmy for the pathogenic variant m.3243A>G in the MTTL1 gene, which is compatible with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome.
Conclusions: Therefore, our clinical case highlights the clinical heterogeneity of this syndrome, as this patient presented with exceptional renal and ocular involvement without damage to other organs that are usually affected. These phenotypes are not well documented in the literature on MELAS.
Randomized Pilot Trial of Cell Phone Support to Improve Medication Adherence among Adolescents and Young Adults with Chronic Health Conditions
Authors: Sayegh Caitlin S. , MacDonell Karen K. , Iverson Ellen , Beard Breaon , Chang Nancy , Vu My H. , Belzer Marvin 
Published: June 2023

Abstract
Background
Adolescents and young adults (AYA) living with chronic health conditions often struggle to develop medication adherence skills. This pilot trial evaluated the impact of a mobile health coaching intervention, Cell Phone Support (CPS), on medication adherence.
Methods
Conditions in this randomized trial (NCT04241627; registered 1/27/2020) were CPS delivered by phone calls (CPS-C), CPS delivered by text messages (CPS-T), or automated text message reminders (ATR). Participants were AYA with different chronic health conditions (i.e., sickle cell disease, solid organ transplant, type 2 diabetes), aged 15–20 years (N = 34). We examined the feasibility, acceptability, and preliminary efficacy of both CPS interventions.
Results
CPS was feasible and acceptable. There was evidence that participants found CPS to be more useful than ATR. In this pilot trial, participants receiving CPS reported relatively stronger increases in adherence, compared to those assigned to ATR. CPS-C slightly outperformed CPS-T.
Conclusions
Providing coaching to AYA struggling with illness self-management via their cell phones may promote their acquisition of medication adherence skills. Although larger studies are needed to confirm the results of this pilot study, phone calls and text messages are both promising modalities for delivering human cell phone support.
Hepatic stellate cell-derived exosome miR-122-5p targets TNFRSF19 to inhibit EMT and fibrosis in intrahepatic biliary epithelial cells via the p38 MAPK pathway
Authors: Zhang Yaqin , Zhang Xiangzhi , Chen Ruofei , Jiao Ziying , Shen Bing , Shuai Zongwen 
Published: June 2023

Abstract
Background and aim: Primary biliary cholangitis (PBC) is a kind of autoimmune mediated chronic cholestatic liver disease, Intrahepatic biliary epithelial cells (IBECs) are the main target cells. The precise effect of miR-122-5p, especially exosomal miR-122-5p in PBC has not been elucidated.
Methods: RNA-sequence analyzed the expression profiles of ncRNAs in peripheral blood exosomes of PBC patients. Elisa measured levels of inflammatory cytokines. The proliferation and apoptosis of HIBECs were detected by CCK8 and flow cytometry. Cells were co-cultured using Transwell chamber. The biomarkers of epithelium-mesenchymal transition (EMT), fibrogenesis, and p38 mitogen-activated protein kinase(MAPK) pathway was detected by RT-qPCR and western blot (WB). Dual luciferase reporter assay confirm the binding of miR-122-5p.
Results: 8531 differential expressed (DE) lncRNAs and 263 DE miRNAs were identified in serum exosomes of PBC patients. Exosomal miR-122-5p was correlated with liver injury and cholestasis indexes, and combined with gp210 and sp100 could improve the sensitivity of PBC diagnosis. In vitro experiments showed that high expression of miR-122-5p promoted the proliferation, inhibited the apoptosis, EMT and fibrosis of HIBECs. TNFRSF19 is the target gene of miR-122-5p and regulate apoptosis signal-regulated kinase 1 (ASK1). P38 MAPK pathway and inflammatory cytokines were down-regulated by miR-122-5p.
Conclusion: miR-122-5p regulates the p38 MAPK signaling pathway by targeting TNFRSF19 and plays an important role in the EMT and fibrosis process of HIBECs. miR-122-5p may be a potential marker for the diagnosis of PBC and therapeutic target.
Silicon sources on biochemical responses and Corynespora cassiicola control in cucumber plants
Authors: Fischer Ivan Herman , Morales João Vitor Pelizzaro , Silva Lucas Meleiro , Bertani Rosemary Marques de Almeida , Deus Angélica Cristina Fernandes , Prado Renato de Mello , Pascholati Sérgio Florentino 
Published: June 2023

Abstract
Target spot (Corynespora cassiicola) is an important leaf disease of cucumber, and studies on its alternative management are essential for the economic viability of the crop. The objective was to evaluate silicates in controlling target spot and its pathogen, as well as to characterize the biochemical responses of plants. Preventive spraying was performed three times, at weekly intervals, with K2SiO3 + Cu and K2SiO3, at the concentrations 0, 28, 56, 84 and 112 mg L− 1 Si. Assessments included mycelial growth and germination in vitro; disease severity; number and diameter of lesions; pathogen sporulation on leaves; activities of the enzymes peroxidase, polyphenol oxidase and β-1,3-glucanase, and leaf levels of phenolic compounds. Silicon had no effect in vitro, nor did it affect lesion diameter and sporulation. The lowest disease severity was observed at five days after inoculation at 56 and 84 mg L− 1 Si, while no control was detected after three and seven days. The lowest number of lesions was found for K2SiO3 + Cu after five days of inoculation and for the concentration 56 mg L− 1 Si after seven days, while for K2SiO3, the number of lesions was lowest at 56 and 112 mg L− 1 Si after five days and at 84 and 112 mg L− 1 Si after seven days. In general, there were no differences between silicates. Enzyme activities and phenolic compound levels were not influenced by Si. Thus, Si had almost no evident effect on target spot control, and no direct effect either on the pathogen or on the biochemical responses of plants.