bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of single- and double-dose intravenous tranexamic acid in hip and knee arthroplasty: a systematic review and meta-analysis
Authors: Yang Yong-Ze , Cheng Qing-Hao , Zhang An-Ren , Yang Xin , Zhang Zhuang-Zhuang , Guo Hong-Zhang 
Published: August 2023

Abstract
Objective
With the increasing prevalence of osteoarthritis of the hip and knee, total joint replacement, the end-stage treatment, provides pain relief and restoration of function, but is often associated with massive blood loss. Tranexamic acid (TXA) has been reported to reduce perioperative blood loss in hip or knee arthroplasty. However, the optimal dose of TXA administration remains controversial. Therefore, we performed a meta-analysis combining data from 5 trials comparing the efficacy and safety of one fixed dose of 1 g intravenously administered TXA with two doses of 1 g each administered intravenously for hip or knee arthroplasty.

Methods
PubMed, Medline, Embase, Web of Science, and The Cochrane Library were searched from January 2000 to February 2023. Our meta-analysis included randomized controlled trials and cohort studies comparing the efficacy and safety of different doses of intravenous TXA (IV-TXA) for THA or TKA. The observation endpoints included total blood loss, postoperative hemoglobin drop, blood transfusion rate, length of hospital stay, incidence of deep venous thrombosis (DVT), and incidence of pulmonary embolism (PE). Meta-analysis was performed according to Cochrane's guidelines and PRISMA statement. The Danish RevMan5.3 software was used for data merging.

Results
Five cohort studies involving 5542 patients met the inclusion criteria. Our meta-analysis showed that the two groups were significantly higher in total blood loss (mean difference (MD) = − 65.60, 95% confidence interval (CI) [− 131.46, 0.26], P = 0.05); blood transfusion rate (risk difference (RD) = 0.00, 95% CI [− 0.01, 0.02], P = 0.55); postoperative hemoglobin (MD = 0.02, 95% CI [− 0.09, 0.13], P = 0.31); postoperative hospital stay days (MD = − 0.13), 95% CI [− 0.35, 0.09], P = 0.25); DVT (RD = 0.00, 95% CI [− 0.00, 0.01], P = 0.67); PE (RD = 0.00, 95% CI [− 0.01, 0.00], P = 0.79). There was some inherent heterogeneity due to variance in sample size across each major study.

Conclusion
1 dose of 1 g and 2 doses of 1 g IV-TXA each time have similar effects on reducing blood loss, blood transfusion rate, postoperative hemoglobin level, and postoperative hospital stay after TKA or THA, without increasing the risk of postoperative complications risk. For patients at high risk of thromboembolic events, one dose of 1 g TXA throughout surgery may be preferred. However, higher-quality RCT is needed to explore the optimal protocol dose to recommend the widespread use of TXA in total joint arthroplasty.
Trial registration We conducted literature selection, eligibility criteria evaluation, data extraction and analysis on the research program registered in Prospero (CRD42023405387) on March 16, 2023.
TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
Authors: Jiao Hai-Shan , Yuan Peng , Yu Jin-Tai 
Published: August 2023

Abstract
Background
Mutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains mysterious.

Main body
Recent new studies reported that TMEM106B proteins form intracellular amyloid filaments which universally exist in various neurodegenerative diseases, sometimes being the dominant form of protein aggregation. In light of these new findings, in this review we systematically examined previous efforts in understanding the function of TMEM106B in physiological and pathological conditions. We propose that TMEM106B aggregations could recruit normal TMEM106B proteins and interfere with their function.

Conclusions
TMEM106B mutations could lead to lysosome dysfunction by promoting the aggregation of TMEM106B and reducing these aggregations may restore lysosomal function, providing a potential therapeutic target for various neurodegenerative diseases.
Maternal adverse childhood experiences and behavioral problems in preschool offspring: the mediation role of parenting styles
Authors: Luo Shengyu , Chen Dezhong , Li Chunrong , Lin Li , Chen Weiqing , Ren Yan , Zhang Yuchi , Xing Fenglin , Guo Vivian Yawei 
Published: August 2023

Abstract
Background
Maternal history of adverse childhood experiences (ACEs) has been found to be associated with children’s health outcomes. However, the underlying mechanisms were unclear. This study aimed to examine the association between maternal ACEs and behavioral problems in their preschool offspring and to explore the potential mediating role of maternal parenting styles in the association.

Methods
A cross-sectional study was conducted involving 4243 mother-child dyads in Chengdu, China. Mothers completed the Adverse Childhood Experiences-International Questionnaire (ACE-IQ) to assess their history of ACEs (i.e., physical abuse, emotional abuse, physical neglect, emotional neglect, witnessing domestic violence, household substance abuse, household mental illness, incarcerated household member, parental separation or divorce, parental death, bullying, and community violence), the short Egna Minnen Beträffande Uppfostran Parent Form (S-EMBU-P) to evaluate their parenting styles (i.e., emotional warmth, rejection, and overprotection), and the 48-item Conners’ Parent Rating Scale (CPRS-48) to measure behavioral problems in their children. Logistic regression models were established to examine the association between cumulative number of maternal ACEs and children’s behavioral problems. The mediating role of parenting styles in this association was explored by generalized structural equation models (GSEM).

Results
Of the participating mothers, 85.8% (n = 3641) reported having experienced at least one type of ACE. Children of mothers with ≥2 ACEs showed a significantly increased risk of behavioral problems across all dimensions, including conduct problems, learning problems, psychosomatic problems, impulsive-hyperactive, anxiety, and hyperactivity index, in both crude and adjusted models (all p-values < 0.05). Dose-response patterns were also observed between the cumulative number of maternal ACEs and children’s behavioral problems. In addition, maternal parenting styles of rejection emerged as a significant mediator, accounting for approximately 8.4–15.0% of the associations.

Conclusions
Our findings indicated an intergenerational association of maternal ACEs with behavioral problems in preschool offspring, which was mediated by maternal parenting styles of rejection. Early screening and targeted intervention strategies are critical to mitigate the downstream consequences of maternal ACEs on young children’s outcomes. Providing support and resources to improve parenting skills may prove beneficial.
Fertility preservation after gonadotoxic treatments for cancer and autoimmune diseases
Authors: Saito Saki , Yamada Mitsutoshi , Yano Rika , Takahashi Kazuko , Ebara Akiko , Sakanaka Hiroe , Matsumoto Miho , Ishimaru Tomoko , Utsuno Hiroki , Matsuzawa Yuichi , Ooka Reina , Fukuoka Mio , Akashi Kazuhiro , Kamijo Shintaro , Hamatani Toshio , Tanaka Mamoru 
Published: August 2023

Abstract
Background
The indications for fertility preservation (FP) have expanded. A few patients who underwent gonadotoxic treatment did not have the opportunity to receive FP, leading to concerns that these patients may develop premature ovarian insufficiency. However, the usefulness of FP in women with reduced ovarian reserve has also been questioned. Progestin-primed ovarian stimulation can improve the controlled ovarian stimulation (COS) protocol, but there is limited data on the efficacy of FP with progestin-primed ovarian stimulation.

Methods
We conducted a prospective study of 43 women with cancer or autoimmune diseases before and after gonadotoxic treatment at the reproductive unit of Keio University Hospital, counselled between 1 January 2018 and 31 December 2021. After counselling, informed consent was obtained for FP from 43 patients, with those who underwent gonadotoxic treatment of the primary disease being prioritised. Gonadotropin-releasing hormone analogue or progestin was used to suppress luteinising hormone in COS before or after gonadotoxic treatment. The number of cryopreserved mature oocytes was the primary outcome.

Results
Forty-three patients and 67 assisted reproductive technology cycles were included in the analysis. The median age at entry was 32 [inter quartile range (IQR), 29–37] years. All patients in the post-gonadotoxic treatment group had their oocytes frozen. Gonadotoxic treatment resulted in fewer oocytes [median 3 (IQR 1–4); pre-gonadotoxic treatment group: five patients, 13 cycles] vs. median 9 (IQR 5–14; pre-gonadotoxic treatment group: 38 patients, 54 cycles; P < 0.001). Although anti-Müllerian hormone levels were lower in the post-gonadotoxic treatment group (n = 5, 13 cycles, median 0.29 (IQR 0.15–1.04) pg/mL) than in the pre-gonadotoxic treatment group (n = 38, 54 cycles, median 1.89 (IQR 1.15–4.08) pg/mL) (P = 0.004), oocyte maturation rates were higher in the post-gonadotoxic treatment group [median 100 (IQR 77.5–100) %] than in the pre-gonadotoxic group [median 90.3 (IQR 75.0–100) %; P = 0.039]. Five patients in the pre-gonadotoxic treatment group had their cryopreserved embryos thawed, of which three had live births.

Conclusions
Oocytes obtained for FP from women with cancer or autoimmune disease for FP are of satisfactory quality, regardless of whether they are obtained post-gonadotoxic treatment or COS protocols.
A heparin-binding protein of Plasmodium berghei is associated with merozoite invasion of erythrocytes
Authors: Gao Junying , Jiang Ning , Zhang Yiwei , Chen Ran , Feng Ying , Sang Xiaoyu , Chen Qijun 
Published: August 2023

Abstract
Background
Malaria caused by Plasmodium species is a prominent public health concern worldwide, and the infection of a malarial parasite is transmitted to humans through the saliva of female Anopheles mosquitoes. Plasmodium invasion is a rapid and complex process. A critical step in the blood-stage infection of malarial parasites is the adhesion of merozoites to red blood cells (RBCs), which involves interactions between parasite ligands and receptors. The present study aimed to investigate a previously uncharacterized protein, PbMAP1 (encoded by PBANKA_1425900), which facilitates Plasmodium berghei ANKA (PbANKA) merozoite attachment and invasion via the heparan sulfate receptor.

Methods
PbMAP1 protein expression was investigated at the asexual blood stage, and its specific binding activity to both heparan sulfate and RBCs was analyzed using western blotting, immunofluorescence, and flow cytometry. Furthermore, a PbMAP1-knockout parasitic strain was established using the double-crossover method to investigate its pathogenicity in mice.

Results
The PbMAP1 protein, primarily localized to the P. berghei membrane at the merozoite stage, is involved in binding to heparan sulfate-like receptor on RBC surface of during merozoite invasion. Furthermore, mice immunized with the PbMAP1 protein or passively immunized with sera from PbMAP1-immunized mice exhibited increased immunity against lethal challenge. The PbMAP1-knockout parasite exhibited reduced pathogenicity.

Conclusions
PbMAP1 is involved in the binding of P. berghei to heparan sulfate-like receptors on RBC surface during merozoite invasion.
Healthcare policy changes in an era of health workforce shortage
Authors: Angel Yoel , Fire Gil 
Published: August 2023

AbstractIn their recent IJHPR article, Wimpfheimer and colleagues outline the implications for the field of anesthesia of two major healthcare policy changes in Israel: The Yatziv Reform in licensing foreign medical graduates and the efforts to reduce residents' on-call shift duration. We argue that these reforms are necessary to strengthen the healthcare workforce and improve the quality of care in the long term, even though they may limit the availability of healthcare personnel for several years, particularly in the field of anesthesia. In this commentary, we examine the background to these policy changes, their likely impact on the medical workforce in Israel in general, and propose steps to reconcile these reforms with the global and national shortage of physicians. We urge policymakers to allocate the required resources and begin preparing for an era of continuous mismatch between physician supply and demand, which will necessitate creative solutions, increased reliance on technology, and the introduction of paramedical professionals to help offload tasks and better utilize the scarce physician workforce.
Performance prediction and enhancement of 5G networks based on linear regression machine learning
Authors: Malekzadeh Mina 
Published: August 2023

AbstractThe feature-rich nature of 5G introduces complexities that make its performance highly conditional and dependent on a broad range of key factors, each with unique values and characteristics that further complicate 5G deployments. To address the complexities, this work develops a new modular model based on machine learning on both architecture and service factors (5GPA) that actively contribute to variations in 5G network performance. The objectives are to address the complications during the design and planning phases according to the requirements before 5G deployment, simplify the whole feature-selection process for different deployments, and optimize 5G network performance. The model is implemented and the results are utilized to determine the correlation between the 5GPA factors and the overall performance. Additionally, a simulated 5G dataset is generated and utilized to make predictions on 5G performance based on unseen factors and values of interest. The reliability of the model is validated by comparing the predicted and actual results in the context of quality of service requirements. The results represent a high level of accuracy, with an average of 95%, and low error rates in terms of mean absolute error, mean squared error, and root mean squared error, averaging 7.60e−03, 1.18e−04, and 8.77e−03, respectively.
The experiences and barriers in addressing type 2 diabetes mellitus-associated erectile dysfunction: a mixed method systematic review
Authors: Hadisuyatmana Setho , Malik Gulzar , Efendi Ferry , Reisenhofer Sonia , Boyd James 
Published: August 2023

Abstract
Introduction
Experiences and determinants connected with type 2 diabetes mellitus-associated erectile dysfunction (T2DMED) in health appointments are not well understood and infrequently reported. This systematic review was undertaken to synthesise evidence of the experiences, facilitators, and barriers around screening ED in men with T2DM during health service consultations.

Methods
The review report was based on the guidelines provided by the Joanna Briggs Institute for conducting mixed-method systematic reviews. Eight electronic databases were searched, including Web of Science, Embase via Ovid, Cumulative Index to Nursing and Allied Health Literature (CINAHL) via EBSCO, ProQuest, PubMed, PsychInfo via Ovid, MEDLINE via Ovid, Portal Garuda. Additionally, the review manually looked through the reference lists of the studies we included. Erectile dysfunction, type 2 diabetes mellitus, screening and barriers were initially used as keywords in the search strategy. All identified primary studies written in English and Bahasa Indonesia, and published between 2001 and 2022 were meticulously screened following an agreed set of inclusion criteria.

Findings
Out of 3468 papers screened, only six were chosen for the review. These included three cross-sectional studies, two qualitative studies, and one mixed-method study. The study quality of the included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist. Based on the checklist criteria, the studies ranged between 5/10 to 9/10 in terms of quality. After synthesizing the findings, four main categories were identified including the willingness to discuss T2DMED, the barriers experienced and perceived, the limited understanding of T2DMED, and the support expected by men with T2DM.

Discussion
Many men kept quiet about their struggles with T2DMED, hoping to bring it up as a topic of discussion during healthcare consultations. Barriers such as embarrassment, a sense of helplessness and reluctance to seek help, financial constraints, and dismissive healthcare professionals hindered them from addressing this issue. Both the participating men and healthcare professionals lacked a comprehensive understanding of T2DMED.

Recommendations
It is important to provide education tailored to men's specific needs and improve awareness about T2DM-associated ED. Creating a more T2DMED-friendly environment could be a potential solution to increase early screening and management. Future research should investigate potential barriers that prevent HCPs from identifying and addressing T2MED since their absence in the identified studies highlights this need.

Systematic review registration
CRD42021292454.
Non-Newtonian nanofluid flow across an exponentially stretching sheet with viscous dissipation: numerical study using an SCM based on Appell–Changhee polynomials
Authors: Khader M. M. , Babatin M. M. , Megahed Ahmed M. 
Published: August 2023

AbstractThe objective of this article is to investigate how the properties of a non-Newtonian Williamson nanofluid flow, which occurs due to an exponential stretching sheet placed in a porous medium, are influenced by heat generation, viscous dissipation, and magnetic field. This study focuses on analyzing the heat transfer process by considering the impact of temperature on the thermal conductivity and viscosity of Williamson nanofluids. Additionally, the research significantly contributes by investigating the flow characteristics of these nanofluids when influenced by slip velocity. Using the spectral collocation method (SCM), the equations that describe the current problem are transformed into a collection of ordinary differential equations and then solved. The SCM proposed here basically depends on the properties of the Appell-type Changhee polynomials (ACPs). First, with the aid of ACPs, we give an approximate formula of the derivatives for the approximated functions. Through this procedure, the provided model is transformed into a nonlinear set of algebraic equations. Physical factors of interest, such as skin friction, the Nusselt number, and the Sherwood number, are explained using tabular expressions. Data are displayed as graphs for the nanofluid’s velocity, temperature, and concentration. The primary findings showed that increasing the Williamson, magnetic, thermal conductivity, and Brownian parameters significantly improves the thermal field. Finally, testing the suggested method with specific cases from some past literature-based publications reveal a good degree of agreement.
Competing for space? A multi-criteria scenario framework intended to model the energy–biodiversity–land nexus for regional renewable energy planning based on a German case study
Authors: Weber Jessica , Steinkamp Tim , Reichenbach Marc 
Published: August 2023

Abstract
Background
The need to balance renewable energy supply with biodiversity conservation has become increasingly urgent in light of current climate, energy, and biodiversity crises. However, the development of wind and solar energy often presents trade-offs such as competing for land use and potentially impacting species and habitats. To address these concerns, ‘priority zones’ for bird and bat species have been proposed as spatial designations for early species protection in the regional planning process. However, there are concerns that the areas suitable for wind and solar energy may be limited further, making it difficult to meet state- and regional-specific spatial targets for renewable energy sites.

Results
To help decision-makers deal with this challenge, a Multi-Criteria Scenario Framework has been developed and analyzed. It involves a habitat model of priority zones for species conservation and techniques from the intuitive logic scenario planning method. Through a regional case study, various planning criteria were analyzed according to scenarios, such as priority zones for species protection, settlement buffers, and forests. The framework indicates how criteria could be balanced to achieve wind energy spatial targets as well as targets for ground-mounted solar energy with the least possible impact. Results show that compared to other planning criteria, species priority zones had limited competition with spatial wind energy targets. Achieving these targets may require minimal adjustments, such as allowing wind energy in 1–3% of completely protected recreational landscapes. To reconcile land use demands in the energy transition, a balance between ‘green’ protected areas is necessary. Additionally, ground-mounted solar energy could replace some of the wind energy spatial targets while also meeting the overall solar development goals.

Conclusions
The framework provides transparency in assessing trade-offs between multiple objectives and helps quantify the ‘costs’ and ‘benefits’ in renewable energy planning. Adapting more flexible planning methods could help resolve the conflict between wind energy and species protection. Joint analysis of the areas needed for wind and solar energy and determining the optimal energy mix are gaining in importance. However, how the benefits of multi-criteria scenarios can be achieved within the confines of preoccupied and siloed organizations remains an ongoing research topic.
Development and validation a model for predicting overall survival of bladder cancer with lung metastasis: a population-based study
Authors: Liu Liang , Sun Fu-zhen , Zhang Pan-ying , Xiao Yu , Ni Hai-xin 
Published: August 2023

Abstract
Background
Although the number of patients with bladder cancer and lung metastasis is increasing there is no accurate model for predicting survival in these patients.

Methods
Patients enrolled in the Surveillance, Epidemiology, and End Results database between 2010 and 2015 were selected for the study. Univariate and multivariate Cox regression were used to determine independent prognostic factors, followed by development of a nomogram based on the multivariate Cox regression models. The consistency index, receiver operating characteristic curve, and calibration curve were used to validate the prognostic nomogram.

Results
506 eligible bladder cancer patients with lung metastasis were enrolled in the study and then divided randomly into training and validation sets (n = 356 vs. n = 150). Multivariate Cox regression analysis indicated that age at diagnosis, primary site, histological type, surgery of the primary site, chemotherapy, bone metastasis, and liver metastasis were prognostic factors for overall survival (OS) in patients with lung metastasis in the training set. The C-index of the nomogram OS was 0.699 and 0.747 in the training and validation sets, respectively. ROC curve estimation of the nomogram in the training and validation sets showed acceptable accuracy for classifying 1-year survival, with an area under the curve (AUC) of 0.766 and 0.717, respectively. More importantly, the calibration plot showed the nomogram had favorable predictive accuracy in both the training and validation sets.

Conclusions
The prognostic nomogram created in our study provides an individualized diagnosis, remedy, and risk evaluation for survival in patients with bladder cancer and lung metastasis. The nomogram would therefore enable clinicians to make more precise treatment decisions for patients with bladder cancer and lung metastasis.