bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioassay-guided isolation in Salvia abrotanoides Karel. stem based on its anti-fungal and anti-trichomonas activity
Authors: Ghanadian Mustafa , Afshar Jahanshahi Rasoul , Fakhim Hamed , Yousefi Hosseinail , Matkowski Adam , Khodadadi Mohammad , Gharibi Shima 
Published: March 2023

Background and purpose:

Salvia abrotanoides is considered a medicinal plant and has a broad distribution in Iran. In Iran's traditional medicine, it is also used to treat leishmaniasis, malaria, atherosclerosis, cardiovascular disease, and as a disinfectant. This research aimed to determine the anti-Candida component from S. abratonoides and anti-Trichomonas natural compounds from the stems of this plant.

Experimental approach:
The plant shoots were collected, dried, and after removing the leaves, grounded. Dried plant material was extracted in a maceration tank, concentrated by a Rotavap, degreased, and fractionated by normal column chromatography. Based on anti-fungal screening against Candida species, Fr. 4, with more anti-fungal activity, was selected for phytochemical analysis, by different chromatographic methods on the silica gel column and Sephadex LH-20. Isolated compounds were elucidated by NMR analysis, mass spectrum, and ultraviolet spectroscopy. Anti-fungal effects were investigated using the fungal suspension, incubation, and parasite-counting methods on purified compounds. Antibacterial effects were assessed using the Broth dilution test and reported according to the MIC parameter.

Findings/Results:
Two diterpenoid compounds named carnosol (compound 1), 11-hydroxy-12-methoxy-20-norabiata-8, 11, 13-trien (compound 2), and a flavonoid: 6,7-dimethoxy-5, 4'-dihydroxyflavone (compound 3) were isolated and identified. Compound 1 had selective anti-fungal effects against C. albicans, C. glabrata, and C. parapsilosis, but weak toxicity against Trichomonas vaginalis with IC50 of 675.8μg/mL, less than metronidazole with an IC50 of 13.2 μg/mL.

Conclusion and implications:
Carnosol as the main component was assayed against Candida, Aspergillus, Rhizopus, and Trichomanas species. The results confirmed its effect on Candida compared to standard drugs.
Cytological Features of “Non-invasive Follicular Tumour with Papillary Like Nuclear Features” – A Single Institutional Experience in India
Authors: Amita K , Rakshitha HB , Sanjay M , Kalappa Prashantha 
Published: March 2023

Background:
The term noninvasive follicular tumor with papillary-like nuclear features (NIFTP) was introduced as a surrogate for noninvasive encapsulated follicular variant of papillary thyroid carcinoma with a defined set of histopathologic criteria. There are very few studies depicting the cytological cues for the diagnosis of NIFTP. The objective of the study was to determine the spectrum of cytological features in fine needle aspiration cytology (FNAC) smears of cases histopathologically diagnosed as NIFTP.

Methods:
This was a retrospective cross-sectional study conducted over a duration of four years between January 2017 and December 2020. All surgically resected cases (n-21), who met the diagnostic criteria of NIFTP on histopathology and who underwent preoperative FNAC were included and reviewed in the study.

Results:
Out of a total of 21 cases, at FNAC, diagnosis of benign, suspicious for malignancy, follicular variant of papillary thyroid carcinoma, and classic papillary thyroid carcinoma (PTC) was rendered in 14 (66.6%), 2 (9.5%), 2 (9.5%), and 3 (14.28%), respectively. Scanty cellularity was noted in 12 (57.1%) cases. Papillae, sheets, and microfollicles were seen in 1 (4.7%), 10 (47.6%), and 13 (61.9%) cases, respectively. Nucleomegaly, nuclear membrane irregularities, nuclear crowding, and overlapping were seen in 7 (33.3%), 9 (42.8%), and 9 (42.8%), respectively. Nucleoli, nuclear grooving, and inclusions were seen in 3 (14.2%) 10 (47.6%), and 5 (23.8%) cases, respectively.

Conclusion:
At FNAC, NIFTP can be found in every category of The Bethesda System for Reporting Thyroid cytopathology (TBSRTC). Nuclear membrane irregularities, nuclear grooving, mild nuclear crowding, and overlapping were noted in a modest number of cases. However, the absence or rare occurrence of features such as papillae, inclusions, nucleoli, and metaplastic cytoplasm may help prevent an overdiagnosis of malignancy.
Clinico-cytomorphological Spectrum of Calcinosis Cutis
Authors: Shastri Malvika , Gautam Pratibha , Diwaker Preeti , Gogoi Priyanka , Arora Vinod K. 
Published: March 2023

Introduction:
The deposition of calcium in the skin is known as calcinosis cutis. It can affect any part of the body and can mimic soft tissue or bony lesions clinically.

Aim:
To describe the clinical and cytomorphologic features of calcinosis cutis on fine needle aspiration cytology smears.

Materials and Methods:
A total of 17 cases reported as calcinosis cutis on fine needle aspiration cytology were reviewed for the available clinical and cytological details.

Results:
The cohort included both adult and pediatric patients. Clinically, the lesions appeared as painless swellings of variable sizes. The common sites affected were the scrotum, iliac region, scalp, pinna, neck, axilla, elbow, arm, thigh, and gluteal region. Aspirate was chalky white, paste-like in all the cases. The cytologic evaluation revealed amorphous crystalline deposits of calcium along with histiocytes, lymphocytes, and multinucleated giant cells.

Conclusions:
Calcinosis cutis has a wide spectrum of clinical presentations. Fine needle aspiration cytology is a minimally invasive approach for diagnosing calcinosis cutis, thus eliminating the need for more extensive biopsy procedures.
Análisis de los emprendimientos post pandemia y el registro de marca en Ecuador
Authors: Parra Karelis del Rocío Albornoz , Ordoñez Jeimmy Lissette Saavedra , Villacís Francisco Anthony Cáceres 
Published: March 2023

Durante la pandemia, muchos se enfrentaron a retos económicos para salir adelante sea desde un emprendimiento naciente, nuevo o negocio establecido, la adaptación fue obligatoria y la necesidad de generar empleo grande; el emprendedor debe moverse y acomodarse de una manera rápida, en función de las tendencias, la globalización, la tecnología, aprovechado también entrar a la sociedad del conocimiento a través de las ventajas de la propiedad intelectual, con el registro de marcas, como bien intangible de altísimo valor económico. El objetivo principal fue indagar sobre el crecimiento de emprendimientos post pandemia y la posible incidencia de registros de marcas. La metodología usada fue descriptiva, documental, deductiva con enfoque cualitativo, llegando a concluir que no hay una cultura alta en los emprendedores sobre la propiedad intelectual, muchos consideran innecesario esta inversión, a pesar que un cierto número si considera importante el registro de este intangible por su valor económico.
The Nexus between Capital Flight and Economic Growth. A Panel Data Investigation of the Mediating Role of Inflation (Kenya: 1986-2021)
Authors: Macheru Joseph 
Published: March 2023

Purpose: This paper investigates whether inflation moderated the relationship between capital flight and economic growth in Kenya. The study attempts to answer one question. Has the effect of capital flight on economic growth been influenced significantly by the inflation rate in Kenya?
Design/methodology/approach – The panel data for the variables under study, collected from World Investment Reports published by World Bank, are analyzed using feasible generalized least squares method to examine the relationship between the dependent and explanatory variables over the period 1987–2018. The interaction effect has been studied to examine the growth impact of FDI in presence of host country characteristics.
Findings – The study found out that foreign portfolio investment outflows, profit repatriations, and inflation rates had no significant effects on economic growth when the interaction variable for inflation was included in the model. Outward foreign direct investment had a significant effect on economic growth when inflation is included in the model as an interaction variable with a positive coefficient indicating they had a positive significant relationship. The interaction variable had a negative but insignificant coefficient indicating that inflation rate did not moderate the relationship between capital flight and economic growth. From the empirical findings, we can infer that capital flight did not constrain resources and subsequently did not affect economic growth negatively. We also find that inflation rate cannot be used to control or moderate the effect of capital flight on the economy and Kenya should not pursue policies geared towards using inflation to moderate this relationship.
Originality/value – The present study provides for the first time comprehensive empirical evidence on the relationship between inflation, economic growth, and the increased rate of capital outflows in Kenya. Therefore, this study would be of prime importance for policymakers.
Originality/value – Very few studies have been conducted to examine the nexus between inflation, capital flight and economic growth in Kenyans financial markets. Assessing the interaction of these variables in Kenya and their impact on economic growth by use of panel data methodology is an original contribution of this paper toward the existing body of knowledge.
Isolation and Celulolytic Activity Assay of Actinobacteria Isolated from Palm Oil Wastewater
Authors: Fitri Lenni , Yurnita Yurnita , Suhartono Suhartono 
Published: March 2023

Cellulose plays an important role in the carbon cycle in nature and is the largest compound. This study aimed to isolate, to characterize and to determine actinobacteria that capable of producing cellulases. The sampling method in this study was carried out by purposive sampling at the outlet point of aeration pond of the wastewater treatment plant (IPAL) from palm oil waste station of PT. Teupin Lada. Isolation of actinobacteria was carried out on Humic Acid Vitamin b Agar (HVA), morphological characterization was carried out on Yeast Malt Agar (YMA), Yeast Starch Agar (YSA), Oatmeal Agar (OA), and microscopic characterization of actinobacteria and measuring the diameter of the clear zone formed on Carboxymethyl Cellulose (CMC) medium using the indicator Congo Red. Eight isolates were obtained from the isolation. Of the 8 isolates obtained, 7 of them were able to produce cellulase enzymes which were measured based on the clear zone formed in the test Congo Red on Carboxymethil Cellulose (CMC), and one isolate did not show any clear zones. The highest value of Cellulolytic Index (IS) was obtained from isolate ATLS-05, namely 8.38 mm.
HIGHLIGHTS

Cellulose plays an important role in the carbon cycle in nature and is the largest compound
The high waste load especially palm oil mill effluent (Elaeis guineensis) or known as Palm Oil Mill Effluent(POME) could cause various problems for the environment and society. POME is wastewater from the palm oil industry, which is one of the most polluting agro-industrial wastes
Actinobacteria are one of the soil microbes which have the greatest abundance and play an important role in the decomposition process. One of the roles of soil microbes is too degrading cellulose

GRAPHICAL ABSTRACT
Flood events change the occurrence and burden of diarrhea among people in Thua Thien Hue province, Vietnam in 2016
Authors: Gia Nguyen Thanh , Pu Jian , Watanabe Toru 
Published: March 2023

People in flooded areas are exposed to the risk of infectious diseases like gastroenteritis via contact with contaminated floodwater. The burden of such diseases has often been estimated using DALYs based on the severity and duration of the disease symptoms but not for psychology. We hypothesized that people in developing countries hit by floods frequently have higher stress related to flood-related diseases than others. This study aimed to describe the psychological impact of floods into the health burden of diarrhea in flood-prone areas in Thua Thien Hue province, Vietnam in 2016. A cross sectional study was conducted from August to September 2016 in Thua Thien Hue province to ask about their feeling about flood-caused diarrhea compared with common diseases which are leading causes of morbidity in the region. The results showed that the participants felt that some diseases such as diarrhea happened more frequently during and after floods. People in non-flooded areas felt that diarrhea and cough that happened more frequently during and after floods were significantly higher than in other areas. The severity/uncomfortableness of diarrhea that participants reported compared with each common disease was significantly different between people in flooded and non-flooded areas. No significant difference between the newly modified disability weight of diseases that participants in flooded and non-flooded areas, felt happened more frequently related to floods. The feeling to diarrhea disease was not affected by floods. A new method to incorporate the psychological impacts of floods into the burden of normal diarrhea was also proposed. Our findings suggest that floods changed the feelings of people in flooded areas about diarrhea by accepting this disease.
INOVACE STANOVANÍ NABÍDKOVÝCH CEN VE STAVEBNÍM PODNIKU – PARAMETRICKÉ ROZPOČTOVÁNÍ
Authors: Vrbka Marek 
Published: March 2023

Článek popisuje inovaci procesu určení nab.dkových cen ve stavebním podniku – parametrické rozpočtování. Autor se zabýv. běžným způsobem tvorby nab.dkových cen ve stavebních podnicích v České Republice a inovací tohoto procesu za účelem zvýšen. jeho efektivity. Parametrické rozpočtování je metoda kvalifikovaných odhadů nabídkové ceny za zhotovení stavebního objektu. Parametrické rozpočtování je založeno na cenových modelech, které definují cenové chování (cenové funkce) a cenovou hladinu (koeficienty), pro určitý typ stavebního objektu. Konkrétní stavební objekt musí být definovaný parametry. Nabídková cena určená parametrickým rozpočtováním ve stavebním podniků má definovanou přesnost, která vychází z krajně přípustné odchylky. Autor popsal metodu stanovení krajně přípustné odchylky. Autor popsal zapracování krajně přípustné odchylky do prostých cash flow inovace.
ZVEDACÍ MECHANISMY PRO MALÉ STAVEBNÍ OBJEKTY – KOMPARATIVNÍ METODA NA BÁZI OBJEMŮ A TYPOVÝCH ČASOVÝCH PLÁNŮ
Authors: Brandtner Michal , Králíček Jiří 
Published: March 2023

Stavebně technologická příprava je velice důležitou součástí výstavbového procesu. Volba nasazení hlavních zvedacích mechanismů je závislá na mnoha faktorech a kritériích jako jsou pozice jeřábu, charakteristiky přepravovaného břemene nebo ekonomické a časové kritéria. Zásadní pro efektivní volbu zvedacích mechanismů je porovnání zejména ekonomických a technologických kritérií stanovených při jejich nasazení během výstavby reálného stavebního objektu. Článek prezentuje vlastní přístup k posouzení vhodnosti malého zvedacího mechanismu na základě automatizovaného časového plánu v kombinaci s objemovou charakteristikou stavby. Pro demonstrování metody je uvedena případová studie a řešení dané problematiky formou porovnání dvou typů zvedacích mechanismů. Konkrétně jde o malý samostavitelný jeřáb a hydraulický manipulátor či drobný automobilový jeřáb. Je uvedena křivka nákladů pro každý mechanismus s přechodovým bodem znázorněným na řadě šesti malých staveb s různými stavebními prostory. Při rozloze 6030 m3 byl nalezen přechodový bod.
DĚDICTVÍ POLDINY HUTĚ V KLADNĚ
Authors: Cestrová Edita 
Published: March 2023

Poldina huť na Kladně kdysi patřila mezi jeden z velkých hutních závodů Československa, její jedinečnost byla díky orientaci na výrobu ušlechtilých ocelí. Byla založena roku 1889 Carlem Wittgensteinem, aby zaplnila mezeru na trhu v nástrojových ocelích na jemnou mechaniku, kosy, pilníky atd. Úspěchem byla především kvalita výrobků a rychlý technický rozvoj. Díky specializovanému zaměření se stala potřebnou a významnou. Během historických období se různě rychle rozvíjela, modernizovala a rozšiřovala svoji rozlohu. Dnes se jedná o plochu brownfieldu, podléhající již řadu let neplánovaným i plánovaným demolicím. Odstraňovány jsou nejen industriální objekty z různých etap výstavby, ale i technologická zařízení. Tento příspěvek se zabývá stručným průřezem historie Poldiny huti v oblasti výstavby a investic s poukázáním na cenné objekty industriálního dědictví.
ROUTE OPTIMIZATION OF MULTIPLE-AGENT TRAVELLING SALESMAN PROBLEM
Authors: Galić Mario 
Published: March 2023

Route optimization is quotidian engineering problem. Problem of finding the optimal and suboptimal routes is one of the most studied optimization problem. In this paper, author firstly presented a short literature overview of the history of routing problems and namely travelling salesman problem (TSP). In the second chapter author presented the usual mathematical formulations for single and multiple agent travelling salesman problem (TSP and mTSP). In chapter three, author used a case study TSP given in the literature which involves one agent and fifteen nodes, modelled the problem in a standard software package (MS Excel’s Visual Basic VBA), solved it by the evolutionary solver in the same software package, confirmed the result and withal verified the model. In the following step, author added one more agent as a hypothetical case of mTSP and solved the problem. In the final chapter author discussed the results and gave conclusions which can be used for further development of the study. The solution was gained in reasonably short computational time and considered as optimal.
POROVNANIE 3D MODELU Z PRIAMEHO MERANIA S DIGITÁLNYM MODELOM RELIEFU
Authors: Ježko Ján 
Published: March 2023

Autor predstavuje postup a výsledky tvorby 3D modelu získaného s priameho merania v teréne a porovnáva výsledky z tvorby modelu s možnosťou získať digitálny model reliéfu (DMR) s iných dostupných zdrojov bez priameho merania v teréne. Všeobecným základom tvorby 3D modelov sú geodetické práce v teréne s využitím metód, ktoré zabezpečia spracovanie geodetických meraní (polohopisu a výškopisu) v danej lokalite. Výsledkom spracovania meračských prác v teréne býva mapový podklad (3D model) v mierke, ktorá slúži projektantovi pre potreby funkčnosti a využitia objektov a lokality. Hlavná časť príspevku je venovaná porovnaniu DMR (digitálny model reliéfu) - produkt ponúkaný GKÚ Bratislava a 3D modelu, ktorý bol vytvorený z priameho merania v teréne.
EXPERIMENTÁLNA A NUMERICKÁ ANALÝZA VPLYVU TRHLÍN NA UHOĽNATENIE DREVENÝCH PRVKOV
Authors: Kamenická Zuzana , Sandanus Jaroslav , Klas Tomáš , Rantuch Peter , Martinka Jozef , Balog Karol 
Published: March 2023

Pri rôznych rozmeroch trhlín môže dochádzať k zmenšeniu reziduálneho prierezu a tým aj mechanickej odolnosti. V tomto článku je analyzovaná rýchlosť uhoľnatenia drevených prvkov s rôznymi trhlinami. Vzorky sú vystavené tepelnému toku v kónickom kalorimetri. Cieľom článku je popísať experiment drevených vzoriek s trhlinami a analyzovať výsledky získané pomocou numerickej analýzy. Z predbežných analýz vyplýva, že trhliny môžu mať signifikantný vplyv na uhoľnatenie dreva v mieste trhliny a v prípade viacerých trhlín v priereze na celý prierez.
ANALÝZA VPLYVU VÝBERU TECHNOLÓGIE MONTÁŽE KROVU RODINNÉHO DOMU S OHĽADOM NA ČASOVÉ TRVANIE A VYNALOŽENÉ FINANČNÉ NÁKLADY
Authors: Majer Radovan , Gregorová Valéria 
Published: March 2023

Z dôvodu optimalizácie nákladov na výstavbu rodinného domu sa môžeme stretnúť neraz s otázkami typu: čo sa oplatí viacej stolica či väzníkový krov?, oplatí sa ho realizovať svojpomocne alebo dodávateľským spôsobom?, ako dlho bude trvať jeho realizácia? Nakoľko v odpovediach na uvedené otázky sa názory odborníkov môžu rozchádzať, v nasledovnom príspevku sa zaoberáme podrobnejšie analýzou konštrukcii krovu, rýchlosťou výstavby a v neposlednom rade výslednou cenou za ich realizáciu.
POTENCIÁL VÝTVARNÉHO A UMELECKÉHO PÔSOBENIA VEGETÁCIE V SÍDELNOM VEREJNOM PRIESTORE
Authors: Marcinková Dana 
Published: March 2023

Vegetácia plní v urbanizovanom prostredí sídiel množstvo d.ležitých funkcií. V súčasnosti, v súvislosti so zhoršovaním kvality životného prostredia, alebo aj s aktuálnymi potrebami adaptácie urbanizovaného prostredia na zmenu klímy, sa zameriavame skôr na jej biologicko-ekologické, environmentálne, či ekosystémové funkcie. Zeleň v urbanizovanom prostredí však zohráva aj významn. estetickú funkciu, na ktorú netreba zabúdať. Článok sa zaoberá potenciálom výtvarn.ho/umeleckého pôsobenia vegetácie v sídelnom verejnom priestore. Vegetácia, nielen v parkoch, sadoch a záhradách ako hlavných komponovaných priestoroch zelene, ale aj v ostatných typoch verejných priestorov, v historických jadrách miest, v s.dliskových štruktúrach, v uliciach, v cestnej zeleni, i v zeleni rôznych areálov, v rámci architektonicko-urbanistickej kompozície priestoru zohráva rôznu úlohu, ale vždy ako plnohodnotný kompozičný prvok.
Dental Bridges for Partial Tooth Loss
Authors: Hill Shannon , Bailey Sharon , Hamson Angie 
Published: March 2023

This review identified limited evidence about the clinical effectiveness of dental bridges for partial tooth loss in adults. The identified studies had several limitations, including limited comparative data and concerns related to a lack of dental bridge specificity. Therefore, the findings related to effectiveness are uncertain.
In adults with partial tooth loss who have dental bridges supported by natural teeth, there may be minimal rates of dental bridge failure, high rates of dental bridge survival, and few complications.
Limited evidence from 1 study with a small number of patients that directly compared all-ceramic dental bridges with metal-ceramic dental bridges reported no failures in either group but suggested that patients with all-ceramic dental bridges may have more complications and changes in patient satisfaction, but the findings were uncertain.
One patient with lived experience shared clinical information related to the use of a dental bridge and reported that the dental bridge helped facilitate eating but they experienced issues with chipping which negatively affected function and satisfaction with the appearance of the bridge, which also had financial implications for repair and replacement of the damaged bridge. None of the studies in this report included direct measures related to the patient-identified outcomes, specifically financial implications.
We did not find any studies that compared dental bridges to partial dentures or different designs of dental bridges, nor did we find any studies on the cost-effectiveness of dental bridges that met the criteria for this review.
We did not find any evidence-based guidelines on the use of dental bridges for adults with partial tooth loss that met the criteria for this review.