bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in neurology: a scoping review
Authors: Moores Ginette , Steadman Patrick E , Momen Amirah , Wolff Elena , Pikula Aleksandra , Bui Esther 
Published: April 2023

ObjectiveHistorically, neurology research has demonstrated a sex bias with mainly male subjects included in clinical trials as well as lack of reporting of data by sex. In recent years, emphasis has been placed on increased participation of female participants and explicit declaration/evaluation of sex differences in clinical research.We aimed to review the available literature examining sex differences across four subspecialty areas in neurology (demyelination, headache, stroke, epilepsy) and whether sex and gender terms have been used appropriately.DesignThis scoping review was performed by searching Ovid MEDLINE, Cochrane Central Registry of Controlled Trials, EMBASE, Ovid Emcare and APA PsycINFO databases from 2014 to 2020. Four independent pairs of reviewers screened titles, abstracts and full texts. Studies whose primary objective was to assess sex or gender differences among adults with one of four neurological conditions were included. We report the scope, content and trends of previous studies that have evaluated sex differences in neurology.ResultsThe search retrieved 22 745 articles. Five hundred and eighty-five studies met the inclusion criteria in the review. The majority of studies were observational, often examining similar concepts designed for a different country or regional population, with rare randomised controlled trials designed specifically to assess sex differences in neurology. There was heterogeneity observed in areas of sex-specific focus between the four subspecialty areas. Thirty-six per cent (n=212) of articles used the terms sex and gender interchangeably or incorrectly.ConclusionsSex and gender are important biological and social determinants of health. However, the more explicit recognition of these factors in clinical literature has not been adequately translated to significant change in neuroscience research regarding sex differences. This study illustrates the ongoing need for more urgent informed action to recognise and act on sex differences in scientific discovery and correct the use of sex and gender terminology.Trial RegistrationThe protocol for this scoping review was registered with Open Science Framework.
Advanced heart failure patients and family caregivers health and function: randomised controlled pilot trial of online dignity therapy
Authors: Yang Weiling , Zhang Xiaonan , Li Yanting , Lv Qingyun , Gao Xinxing , Lin Mei , Zang Xiaoying 
Published: April 2023

ObjectivesThis research investigated the effectiveness of the caregiver-mediated online dignity therapy in enhancing dyadic health and family function.MethodsHeart failure (HF) family dyads were recruited between May and December 2021 from a university-affiliated hospital in China. The dyads (N=70) were randomly allocated to the intervention group and the control group. We assessed patients’ outcomes (hope, well-being, Family APGAR Index and quality of life (QoL)) and their family caregivers’ outcomes (anxiety, depression and Family APGAR Index) at baseline (T0), 1 week (T1), 4 weeks (T2) and 8 weeks (T3) after discharge.ResultsFor patients, the difference over time was significant in QoL (p<0.001). The interaction effects were significant for hope (p<0.001), well-being (p<0.001), Family APGAR Index (p<0.001) and QoL (p=0.007). For family caregivers, a significant difference in depression (p=0.001) was found within groups. Meanwhile, the interaction effects were significant on anxiety (p=0.002) and depression (p=0.016).ConclusionsCaregiver-mediated online dignity therapy among patients with advanced HF had potential to enhance patient outcomes (level of hope, well-being, family function and QoL) and alleviate caregiver outcomes (anxiety, depression) at 4-week and 8-week follow-up. Thus, we provided scientific evidence for palliative care for advanced HF.Trial registration numberChiCTR2100053758.
Gravitational lensing by using the 0th order of affine perturbation series of the deflection angle of a ray near a photon sphere
Authors: Tsukamoto Naoki 
Published: April 2023

AbstractThe 0th order of affine perturbation series of the deflection angle of a ray near a photon sphere is more accurate than a deflection angle in a strong deflection limit, which is used often, because the later has hidden error terms. We investigate gravitational lensing by using 0th order affine perturbation series of the deflection angle in a general asymptotically-flat, static, and spherical symmetric spacetime with the photon sphere. We apply our formula to Schwarzschild black hole, Reissner–Nordström black hole, and Ellis–Bronnikov wormhole spacetimes as examples. By comparing observables by using the deflection angles, we show that we can ignore the effect of the hidden error terms in the the deflection angle in the strong deflection limit on the observables in a usual lens configuration with the photon sphere since the hidden error terms are tiny. On the other hand, in a retro lensing configuration, the deflection angle in the strong-deflection-limit analysis have error of several percent and the 0th order of affine perturbation series of the deflection angle has almost half of the error. Thus, in the retro lensing configuration, we should use the 0th order of affine perturbation series of the deflection angle rather than the deflection angle in the strong-deflection-limit analysis. The 0th order of affine perturbation series of the deflection angle can give a brighter magnification by a dozen percent than the one by using the deflection angle in the strong-deflection-limit analysis.
Spontaneous scalarization in proto-neutron stars
Authors: Rahimi Fahimeh , Rezaei Zeinab 
Published: April 2023

AbstractProto-neutron stars are born when a highly evolved and massive star collapses under gravity. In this paper, we investigate the spontaneous scalarization in proto-neutron stars. Based on the scalar tensor theory of gravity as well as the physical conditions in proto-neutron star, we examine the structure of proto-neutron star. To describe the fluid in proto-neutron star, we utilize SU(2) chiral sigma model and the finite temperature extension of the Brueckner–Bethe–Goldstone quantum many-body theory in the Brueckner–Hartree–Fock approximation. Here, we apply the equation of state of proto-neutron stars considering different cases i.e. hot pure neutron matter and hot $$\beta $$
β
-stable neutron star matter without neutrino trapping as well as with neutrino trapping. The effects of temperature and entropy of proto-neutron stars on the star structure are also studied. Our results confirm that the spontaneous scalarization is affected by different physical conditions in proto-neutron stars.
Interannual Variation in Top-of-Atmosphere Upward Shortwave Flux over the Arctic Related to Sea Ice, Snow Cover, and Land Cloud Cover in Spring and Summer
Authors: Amma Michinari , Hayasaka Tadahiro 
Published: April 2023

Abstract
We investigated the interannual variations in the annual mean and seasonal cycle of upward shortwave radiation at the top of the atmosphere (TOA SW↑) over the Arctic using the Clouds and the Earth’s Radiant Energy System (CERES) observation data during 2001–20. The annual mean TOA SW↑ over the Arctic showed a decreasing trend from 2001 to 2012 (−2.5 W m−2 decade−1) and had a large interannual variability after 2012. The standard deviation of detrended TOA SW↑ increased from 0.4 W m−2 in 2001–12 to 1.1 W m−2 in 2012–20. Over land, TOA SW↑ variation was related to snow cover in May; snow cover, cloud fraction, and cloud optical depth (COD) in June; and cloud fraction and COD in July. Over ocean, TOA SW↑ variation in June and July was linked to sea ice cover. TOA SW↑ variation over ocean in June and July after 2012 was highly related to the North Atlantic Oscillation (NAO). This study suggests that changes in the large annual mean TOA SW↑ variability after 2012 are explained by the timing of land snow and sea ice melt in spring and summer and cloud variability over land in summer.
Regulating the Rorts: The Legal Governance of Grants Programs in Australia
Authors: Ng Yee-Fui 
Published: April 2023

AbstractNumerous recent scandals have surfaced relating to the Australian government allegedly engaging in ‘pork barrelling’, that is, the partisan channelling of grants funding to government electorates, instead of merit-based allocation. Yet the probity of the use of public money is crucial towards preserving public trust in Australian democratic institutions. This article will critically analyse the legal accountability mechanisms for grants funding through public finance legislation, ‘soft law’ such as grants, guidelines and ministerial standards, and the availability of legal redress. It will also examine political accountability mechanisms, including the operation of parliamentary committees, the Auditor-General and the Ombudsman. The author argues that although political regulation provides transparency in the government’s use of public funds, it remains ineffective to combat the government’s deeply entrenched incentives to allocate grants in a partisan manner. As such, it is contended that stronger legal accountability in terms of enforceable rules and regulations is required to reform grants regulation towards improving the probity and accountability of the use of public funding.
The impact of COVID-19 on palliative care social work: An online survey by a European Association of Palliative Care Task Force
Authors: Roulston Audrey , Ross Jana , Dobrikova Patricia , Piccione Tania , Reigada Carla , Mackova Marie , Wasner Maria 
Published: April 2023

Background: The SARS-Cov-2 (COVID-19) pandemic affected the delivery of health and social care services globally. However, little is known about how palliative care social work services were impacted. Aim: The aim of this study was to capture and analyse data from palliative care social workers who provided professional support in a range of settings across 21 countries during the COVID-19 pandemic. Design: A cross-sectional survey-based design was used for this empirical study and this paper primarily focuses on the quantitative responses. Setting/participants: Participants, palliative care social workers, were drawn internationally via members of the EAPC Social Work Task Force and the World Hospice Palliative Care Social Work network. Results: We received 362 survey responses from 21 countries. Most (79%) respondents worked with adults in in-patient units or hospitals. The number of referrals during COVID-19 increased more in non-European countries, compared to European countries. The full range of social work services could no longer be delivered, existing services changed and 65.3% of participants reported higher levels of pressure during the pandemic, which was linked to higher levels of staff absence and additional duties. For many respondents (40.8%), this included facilitating online communication between patients and their families. Conclusions: Our findings indicate that restrictions to limit the spread of COVID-19 resulted in adaptations to service delivery, increased pressure on staff and moral distress, like other health and social care professions. All members of the palliative team need support and supervision to ensure effective interdisciplinary working and team cohesion.
Development and validation of nomograms for predicting overall survival and cancer-specific survival in elderly patients with locally advanced gastric cancer: a population-based study
Authors: Sun Yuqi , Li Zequn , Tian Yulong , Gao Chao , Liang Benjia , Cao Shougen , Liu Xiaodong , Liu Xuechao , Meng Cheng , Xu Jianfei , Yang Hao , Zhou Yanbing 
Published: April 2023

Abstract
Objective
To evaluate the multiple factors influencing the survival of elderly patients with locally advanced gastric cancer (LAGC) and develop and validate the novel nomograms for predicting the survival.

Methods
The clinical features of patients treated between 2000 and 2018 were collected and collated from the Surveillance, Epidemiology, and End Results (SEER) database and three medical centres in China, and the patients were randomly divided into a training cohort (3494), internal validation cohort (1497) and external validation cohort (841). Univariate and multivariate analyses of the prognostic values were performed to identify independent prognostic factors associated with overall survival (OS) and cancer-specific survival (CSS), and two nomogram models were developed. Harrell’s concordance index (C-index) and calibration curves were employed to assess discrimination and calibration. Decision curve analysis (DCA) and receiver-operating characteristic (ROC) curves were utilized to investigate the clinical usefulness.

Results
In the SEER database, the 5-year OS of the patients was 31.08%, while the 5-year CSS of the patients was 44.09%. Furthermore, in the external validation set, the 5-year OS of the patients was 49.58%, and the 5-year CSS of these patients was 53.51%. After statistical analysis, nine independent prognostic factors of OS and CSS were identified, including age, race, tumour size, differentiation, TNM stage, gastrectomy type, lymph node metastasis (LNM), lymph node ratio (LNR) and chemotherapy. The C‐index (approximately 0.7) and calibration curve (close to the optimal calibration line) indicated satisfactory discrimination and calibration of the nomogram. DCA and ROC curves showed that the developed nomogram was superior to TNM stage.

Conclusion
The novel validated nomogram could accurately predict the prognosis of individual elderly patients with LAGC and guide the selection of clinical treatment measures.
Suicides by pesticide ingestion in Pakistan and the impact of pesticide regulation
Authors: Dabholkar Shweta , Pirani Shahina , Davis Mark , Khan Murad , Eddleston Michael 
Published: April 2023

Abstract
Introduction
Suicide is a major public health problem in Pakistan, accounting to approximately 19,331 deaths every year. Many are due to consumption of acutely toxic pesticides; however, there is a lack of national suicide data, limiting knowledge and potential for intervention. In this paper, we aimed to review the literature on pesticide self-poisoning in Pakistan to identify the most problematic pesticides in relation to national pesticide regulations.

Methods
Information on the currently registered and banned pesticides was obtained from Ministry of National Food Security and Research while data on pesticide import and use was extracted from FAOSTAT. We searched the following sources for articles and research papers on poisoning in Pakistan: Cumulative Index to Nursing and Allied Health (CINAHL), Google Scholar, Applied Social Sciences Index and Abstracts (ASSIA), Excerpta Medica (EMBASE), National Library of Medicine’s MEDLINE (PUBMED), PS102YCHINFO and Pakmedinet.com using the search terms ‘self-poisoning’, ‘deliberate self-harm’, ‘suicide’, ‘methods and means of suicide’, ‘organophosphate’, ‘wheat pill’, ‘aluminium phosphide’, ‘acute poisoning’, OR ‘pesticides’, AND ‘Pakistan’.

Results
As of May 2021, 382 pesticide active ingredients (substances) were registered in Pakistan, of which five were WHO hazard class Ia (extremely hazardous) and 17 WHO hazard class Ib (highly hazardous). Twenty-six pesticides, four formulations, and seven non-registered pesticides had been banned, of which two were WHO class Ia and five Ib. We identified 106 hospital-level studies of poisoning conducted in Pakistan, of which 23 did not mention self-poisoning cases and one reported no suicidal poisoning cases. We found no community or forensic medicine studies. Of 52,323 poisoning cases identified in these papers, 24,546 [47%] were due to pesticides. The most commonly identified pesticide classes were organophosphorus (OP) insecticides (13,816 cases, 56%) and the fumigant aluminium phosphide (3 g 56% tablets, often termed ‘wheat pills’; 686 cases, 2.7%). Few studies identified the particular pesticides involved or the resulting case fatality.

Conclusion
We found pesticide poisoning to be a major cause of poisoning in Pakistan, with OP insecticides and the fumigant aluminium phosphide the main pesticides identified. Withdrawal of Class I pesticides (as proposed to occur nationally in 2022) and high concentration aluminium phosphide tablets should rapidly reduce suicidal deaths by reducing the case fatality for low-intention poisoning cases. National cause of death data and forensic toxicology laboratory data identifying the pesticides responsible for deaths will be important to assess impacts of the proposed national ban.
A comprehensive health-promoting neighborhood intervention to improve health care seeking behavior among reproductive age Iranian women
Authors: Rahimi Tahereh , Morowatisharifabad Mohammad Ali , Farajkhoda Tahmineh , Fallahzadeh Hossein 
Published: April 2023

Abstract
Background
Women’s health care seeking delays remains an unresolved major public health problem in developing and underdeveloped countries. This study aimed to evaluate a health-promoting neighborhood intervention to improve health care seeking behavior (HCSB) among reproductive age Iranian women using Health Promotion Model (HPM).

Method
This randomized controlled trial was conducted on 160 women of reproductive age in two groups: experimental and control. Data were collected by self-administered questionnaire based on HPM constructs and a medical symptom checklist. A health-promoting neighborhood intervention was performed in seven sessions for the experimental group. HCSB and HPM constructs were measured before and 3 months after intervention in the two groups. p < 0.05 was considered significant level.

Results
The average mean age of participants was 30.45 ± 7.80 years. After intervention, the mean score of self-efficacy, interpersonal influences, commitment to plan and HCSB was increased significantly in women in the experimental group, while negative constructs such as perceived barriers, negative activity-related affect, and immediate competing demands and preferences significantly decreased (p < 0.05). In addition, the mean score of referring for symptoms such as excessive sweating, persistent fatigue or weakness, headache, bleeding or spotting between periods, vaginal itching and irritation, unusual vaginal discharge, flashing, chest pain, rapid heartbeats, aching muscles or joints, urinary problems and some mental disorder was increased significantly in experimental group compared to control group (p < 0.05).

Conclusions
The results of study show that an intervention based on the HPM have a positive impact on HCSB and its associated factors and can help improve women’s health behaviors and health outcomes.
Examining the influence of health sector coordination on the efficiency of county health systems in Kenya
Authors: Nyawira Lizah , Njuguna Rebecca G , Tsofa Benjamin , Musiega Anita , Munywoki Joshua , Hanson Kara , Mulwa Andrew , Molyneux Sassy , Maina Isabel , Normand Charles , Jemutai Julie , Barasa Edwine 
Published: April 2023

Abstract
Background
Health systems are complex, consisting of multiple interacting structures and actors whose effective coordination is paramount to enhancing health system goals. Health sector coordination is a potential source of inefficiency in the health sector. We examined how the coordination of the health sector affects health system efficiency in Kenya.

Methods
We conducted a qualitative cross-sectional study, collecting data at the national level and in two purposely selected counties in Kenya. We collected data using in-depth interviews (n = 37) with national and county-level respondents, and document reviews. We analyzed the data using a thematic approach.

Results
The study found that while formal coordination structures exist in the Kenyan health system, duplication, fragmentation, and misalignment of health system functions and actor actions compromise the coordination of the health sector. These challenges were observed in both vertical (coordination within the ministry of health, within the county departments of health, and between the national ministry of health and the county department of health) and horizontal coordination mechanisms (coordination between the ministry of health or the county department of health and non-state partners, and coordination among county governments). These coordination challenges are likely to impact the efficiency of the Kenyan health system by increasing the transaction costs of health system functions. Inadequate coordination also impairs the implementation of health programmes and hence compromises health system performance.

Conclusion
The efficiency of the Kenyan health system could be enhanced by strengthening the coordination of the Kenyan health sector. This can be achieved by aligning and harmonizing the intergovernmental and health sector-specific coordination mechanisms, strengthening the implementation of the Kenya health sector coordination framework at the county level, and enhancing donor coordination through common funding arrangements and integrating vertical disease programs with the rest of the health system. The ministry of health and county departments of health should also review internal organizational structures to enhance functional and role clarity of organizational units and staff, respectively. Finally, counties should consider initiating health sector coordination mechanisms between counties to reduce the fragmentation of health system functions across neighboring counties.
Complex and pleiotropic signaling pathways regulated by the secreted protein augurin
Authors: Richter Margaux , Lalli Enzo , Ruggiero Carmen 
Published: April 2023

AbstractThe secreted protein augurin, the product of the tumor suppressor gene Ecrg4, has been identified as a peptide hormone in the human proteome in 2007. Since then, a number of studies have been carried out to highlight its structure and processing and its potential roles in physiopathology. Although augurin has been shown to be implicated in a variety of processes, ranging from tumorigenesis, inflammation and infection to neural stem cell proliferation, hypothalamo-pituitary adrenal axis regulation and osteoblast differentiation, the molecular mechanisms of its biological effects and the signaling pathways it regulates are still poorly characterized. Here we provide a comprehensive overview of augurin-dependent signal transduction pathways. Because of their secreted nature and the potential to be manipulated pharmacologically, augurin and its derived peptides represent attractive targets for diagnostic development and discovery of new therapeutic agents for the human diseases resulting from the deregulation of the signaling cascades they modulate. From this perspective, the characterization of the precise nature of augurin derived peptides and the identification of the receptor(s) on the cell surface conveying augurin signaling to downstream effectors are crucial to develop agonists and antagonists for this protein.