bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of high‐risk AML in a patient with advanced systemic mastocytosis
Authors: Fazio Manlio , Vetro Calogero , Markovic Uroš , Duminuco Andrea , Parisi Marina , Maugeri Cinzia , Mauro Elisa , Parrinello Nunziatina Laura , Stagno Fabio , Villari Loredana , Triolo Anna Maria , Stella Stefania , Palumbo Giuseppe A. , Di Raimondo Francesco , Romano Alessandra , Zanotti Roberta 
Published: July 2023

AbstractAggressive SM + AML has limited therapeutic options. Even a strong combination of decitabine–venetoclax–midostaurin has a transient effect on AML and a mitigated effect on SM. Larger series are required to identify the best therapeutic strategy.
Genetic characterization of FODMAPs and ATIs in heritage and modern spring wheat
Authors: Bajgain Prabin , Boakye Prince G. , Kougblenou Ibilola , Murai Takehiro , Annor George A. , Anderson James A. 
Published: July 2023

AbstractThe fermentable oligo‐, di‐, and monosaccharides and polyols (FODMAPs) and amylase–trypsin inhibitors (ATIs) present in wheat flour can trigger irritable bowel syndrome (IBS) symptoms and intestinal inflammation. Lowering FODMAPs and ATIs concentrations in wheat flour could make the grain accessible to humans with IBS. This study evaluated a diverse panel of heritage and modern spring wheat lines for FODMAPs and ATIs concentrations and carried out a genome‐wide association analysis. A moderately strong population structure was observed as the first two principal component axes explained 10.9% of the genotypic variation, and lines grouped into three clusters. Trait correlations within and across locations ranged from −0.33 to 0.87. Broad‐sense heritabilities ranged from 0.30 to 0.67. Evaluation of 33 varieties released by the University of Minnesota between 1915 and 2020 revealed no significant changes over time in ATIs or FODMAPs concentrations. Association analysis resulted in detection of 38 quantitative trait loci (QTL) in 12 chromosomes and three of the 38 QTL were common between two traits in the St. Paul location. The QTL were of small to medium effect as the range of explained phenotypic variation was 4.9%–11.8%. There was no overlap among the QTL regions reported in this research compared with those reported from previously published studies. Genomic prediction models predicted the traits with low to moderate trait correlations that ranged from 0.13 to 0.34. Discovery of markers associated with FODMAPs and ATIs, in conjunction with a genome‐wide selection strategy, could aid in selection of breeding lines with desirable concentrations of these compounds.
Developing a Human Performance Model Based Systems Engineering System Architecture (MBSE‐SA) for Defense Applications
Authors: Sarathi Tara , Cyr Jillian , Morris Heather , DeLaura Rich , Balcius James , Collins Paula , Shatz Michael 
Published: July 2023

AbstractThe military has limited means to objectively evaluate soldier and squad performance, leading to sub‐optimal operational, training, and acquisition decisions. Part of this limitation stems from the fact that the ability to monitor, predict, and enhance soldier and squad performance is a complex System of Systems (SoS) undertaking. To address this integration challenge, we developed a comprehensive conceptual framework that maps mission‐level success to measures of task effectiveness and human performance that quantify the impact of emerging technologies and interventions. In addition, by leveraging lessons learned from a previous effort that developed a Wearables MBSE system architecture (MBSE‐SA) and methodology for military health monitoring systems, we developed a Human Performance MBSE‐SA to capture and apply the conceptual framework, which provides the foundation for several system‐level and program‐level analyses, including gap identification. This paper presents the Human Performance MBSE‐SA and an illustration of its utility in showing the connections among ongoing military research efforts, strategic source requirements, and operational use cases.
Investigating Systems Engineering Approaches in the Norwegian Construction Industry: A Multi‐Case Study
Authors: Lynghaug Tobias Fredrik , Kokkula Satyanarayana , Muller Gerrit 
Published: July 2023

AbstractThere is an increasing application of Systems Engineering in the Norwegian construction industry. This paper investigates the effects of a Systems Engineering approach on project management performance, prerequisites for success, and which elements contribute to effectiveness from a technical contractor perspective. First, we find a positive perception of Systems Engineering's effect on time, cost, and quality. Second, we provide and rank a list of 12 prerequisites for success. Third, we quantify the perceived importance of five elements of the systems engineering process. Finally, we find a disconnect between what seems to be essential processes and prerequisites and what gets done in practice. To improve Systems Engineering performance, we recommend improving Systems Engineering competence and capabilities, increasing the formality of requirements analysis and documentation, and front‐loading the effort and allocation of resources in projects.
Git‐based Model Management for Quality Monitoring of Systems Engineering Models
Authors: Lehner Daniel , Vamberszky Simon , Wieland Konrad , Siegl Daniel 
Published: July 2023

AbstractThe management of Systems Engineering Models is becoming a crucial requirement when developing complex systems. Particularly with the advance of agile MBSE, Systems Engineering Models evolve constantly. Therefore, for managing Systems Engineering Models, this evolution has to be supported, including concurrent work on one model. Therefore, Git‐based solutions are emerging nowadays also in the Systems Engineering domain. Dedicated model differencing and conflict resolution approaches are provided by extensions of the base support of Git, which is mostly oriented to textual artefacts. However, the monitoring and management of the System Engineering Models hosted in Git repositories is still an open challenge. In this paper, we present a Git‐based model management approach for monitoring the quality of Systems Engineering Models. We outline the architecture of the approach as well as the proposed Git‐based model management approach and discuss the realization based on Enterprise Architect and LieberLieber LemonTree. In addition, we demonstrate the approach by a running example and outline future directives.
The association between sonographic common bile duct dilatation and outcomes in emergency department patients with cholangitis
Authors: Rotter Ayelet , Granat Nadav , Koslowsky Benjamin , Bdolah‐Abram Tali , Schwartz Alon D. , Alpert Evan Avraham 
Published: July 2023

AbstractBackgroundThe presentation of the patient with acute cholangitis (AC) ranges from mild illness to life‐threatening shock. Therefore, prompt diagnosis and treatment are critical. Abdominal ultrasound (US) is the imaging of choice to locate bile duct dilatation. Other modalities include abdominal computed tomography (CT) or endoscopic retrograde cholangiopancreatography (ERCP).ObjectivesTo determine whether sonographic common bile duct dilatation in emergency department (ED) patients with AC predicts outcomes including sepsis, hospital length of stay (LOS), admission to the intensive care unit (ICU), time to ERCP, and mortality.MethodsElectronic medical records of all patients hospitalized in a tertiary care medical center between July 2012–February 2021 with a discharge diagnosis of cholangitis were assessed. Patients were dichotomously classified as CBD dilated or CBD non‐dilated based on ultrasound. Dilation was defined as CBD larger than 6 mm in patients younger than 60 or larger than 6 mm + 1 mm per decade in patients over 60.ResultsThe study included 271 patients‐ 172 with CBD dilation versus 99 without. Mean LOS was 9.92 days for those with a dilated CBD versus 13.4 days without. The mean time to ERCP was 4.26 days for those with a dilated CBD versus 6.56 days without. Sepsis, mortality, and ICU admission were scarce and there was no statistically significant difference between the cohorts.ConclusionPatients with a dilated CBD per the abdominal US performed during the patient's ED stay, underwent ERCP earlier, and were hospitalized fewer days than patients without CBD dilation.
French dermatologists' opinions and practices with regard to adjuvant therapy in stage III melanoma
Authors: Rolland Marion , Oger Emmanuel , Dinulescu Monica , Lesimple Thierry , Russo David , Pracht Marc , Porneuf Marc , Dalac Sophie , Giacchero Damien , Jouary Thomas , Lebbé Celeste , Leccia Marie-Thérèse , Maubec Eve , Meyer Nicolas , Mortier Laurent , Dupuy Alain 
Published: July 2023

AbstractBackgroundIn 2018, the European Medicines Agency authorized adjuvant therapy for patients with resected stage III melanoma.ObjectivesThe objective of the present study (performed in France) was to assess dermatologists' and oncologists' opinions and prescribing habits in this context.MethodsFrom 28 May to 8 June 2021, we performed an online survey of members of the French Groupe de Cancérologie Cutanée (GCC) skin cancer interest group.ResultsThirty‐eight practitioners replied to the survey. For BRAF‐mutant melanoma, 58% of the practitioners favoured immunotherapy (IT). If they themselves were to suffer from melanoma with a BRAFV600 mutation, 65% would choose IT for stage IIIB disease, and 72% would choose IT for stage IIID disease. For stage IIIA melanoma with a positive sentinel lymphatic node (SLN) biopsy <1 mm, 32% of the practitioners stated that they would not offer adjuvant therapy. Sixty‐three percent of the practitioners disagreed with restricting adjuvant therapy to patients aged 80 and over. Although 84% of the practitioners were aware of the cost of adjuvant therapy, 81% did not take account of this factor in their treatment decisions. In patients with a positive SLN biopsy, 90% of the practitioners stated that they would not recommend complete lymph node dissection. Eighty percent of the surveyed practitioners discussed the potential impact of treatments on fertility, respectively with their male and female patients. Of these practitioners, 63%–72% (depending on the situation) stated that they would recommend fertility preservation procedures.ConclusionsThis work points out some debated issues among French dermatologists and oncologists regarding adjuvant therapy in stage III melanoma. Our present results might prompt more comprehensive studies of these particular points.
What do people affected by amyotrophic lateral sclerosis want from health communications? Evidence from the ALS Talk Project
Authors: Genuis Shelagh K. , Luth Westerly , Bubela Tania , Johnston Wendy S. 
Published: July 2023

AbstractIntroduction/AimsHealth communication is central to effective, supportive amyotrophic lateral sclerosis (ALS) clinical care. Guidance for ALS communication is limited, focuses on diagnosis disclosure, and frequently relies on expert consensus and/or reviews. Patient‐based evidence is needed to guide ALS health communication. We investigated how the experiences of ALS patients and family caregivers can inform effective communication practices from diagnosis to end‐of‐life.MethodsData were drawn from the ALS Talk Project, an asynchronous, online focus group study. Seven focus groups and five interviews (105 participants) were conducted. Data were qualitatively analyzed using directed content analysis and the constant‐comparative approach.ResultsWe found four primary themes: communication content, communication circumstances, information sufficiency, and communication manner. Data indicate participants relied on clinicians for medical information but also wanted practical information; health communication should attend to the circumstances within which conversations occur; information must be sufficient for individual needs, without overwhelming; and an empathetic, direct, and honest manner facilitated trust. Participants identified communication challenges and strategies to improve communication across major themes, including stepwise approaches and conversations tailored to individuals and their heterogeneous disease experiences.DiscussionHealthcare professionals should discuss patient/caregiver communication preferences early in the therapeutic relationship, co‐develop a communication agreement, and update the agreement in response to changing needs and disease progression. This will foster regular discussion of information needs and promote timely discussions of challenging topics, including advance care, while giving patients and families a sense of control. Findings may have implications for other neuromuscular disease and/or seriously ill populations.
An effective case of bronchoscopic balloon dilatation for tuberculous bronchial stenosis
Authors: Ichikawa Yukari , Kurokawa Koji , Furusho Shiho , Nakatsumi Yasuto , Yasui Masahide , Katayama Nobuyuki 
Published: July 2023

AbstractEndobronchial tuberculosis often causes bronchial stenosis. Balloon dilation is a minimally invasive and effective bronchoscopic intervention for bronchial stenosis; however, reports on balloon dilation in older individuals are limited. We present a case of a 77‐year‐old woman with endobronchial tuberculosis and clarify the efficacy and safety of balloon dilation. She presented with dyspnea, right lung atelectasis, and respiratory failure 55 days after initiation of antituberculosis therapy. We performed bronchoscopic balloon dilatation for the right main bronchial stenosis. Consequently, respiratory failure rapidly improved. Chest computed tomography (CT) showed improved lung atelectasis; however, severe bronchial stenosis and rhonchi persisted. Therefore, we performed a second balloon dilatation. CT 3 months after the first balloon dilation showed right upper bronchial stenosis and right lung middle lobe atelectasis. Restenosis was absent 21 months after third balloon dilatation. Bronchoscopic balloon dilation is effective for restenosis with repeated treatment and can be safely performed in older individuals.
Terrain‐derived measures for basin conservation and restoration planning
Authors: Matt Jeremy E. , Underwood Kristen L. , Diehl Rebecca M. , Lawson K. S. , Worley Lindsay C. , Rizzo Donna M. 
Published: July 2023

AbstractCenturies of human development have altered the connectivity of rivers, adversely impacting ecosystems and the services they provide. Significant investments in natural resource projects are made annually with the goal of restoring function to degraded rivers and floodplains and protecting freshwater resources. Yet restoration projects often fall short of their objectives, in part due to the lack of systems‐based strategic planning. To evaluate channel‐floodplain (dis)connectivity and erosion/incision hazard at the basin scale, we calculate Specific Stream Power (SSP), an estimate of the energy of a river, using a topographically based, low‐complexity hydraulic model. Other basin‐wide SSP modeling approaches neglect reach‐specific geometric information embedded in Digital Elevation Models. Our approach leverages this information to generate reach‐specific SSP‐flow curves. We extract measures from these curves that describe (dis)connected floodwater storage capacity and erosion hazard at individual design storm flood stages and demonstrate how these measures may be used to identify watershed‐scale patterns in connectivity. We show proof‐of‐concept using 25 reaches in the Mad River watershed in central Vermont and demonstrate that the SSP results have acceptable agreement with a well‐calibrated process‐based model (2D Hydraulic Engineering Center's River Analysis System) across a broad range of design events. While systems‐based planning of regional restoration and conservation activities has been limited, largely due to computational and human resource requirements, measures derived from low‐complexity models can provide an overview of reach‐scale conditions at the regional level and aid planners in identifying areas for further restoration and/or conservation assessments.
Extremitätenerhaltende Resektion von Weichteilsarkomen in der Regio axillaris
Authors: Stauss Ricarda , Graulich Tilman , Omar Pacha Tarek , Omar Mohamed 
Published: July 2023

Zusammenfassung
Operationsziel
Tumoren mit Lokalisation in der Regio axillaris stellen durch die enge anatomische Beziehung zu neurovaskulären Strukturen eine besondere Herausforderung für die Resektion dar. Operationsziel ist die R0-Resektion unter Wahrung eines maximalen Funktionserhalts.

Indikationen
Weichteilsarkome, Metastasen.

Kontraindikationen
Fortgeschrittene Stadien mit Infiltration neurovaskulärer Strukturen, Lokalisation des Biopsietrakts erfordert ausgedehnte Resektion, palliative Behandlungssituation.

Operationstechnik
Erweiterter deltoideopektoraler Zugang. Ansatznahes Ablösen des M. pectoralis major et minor. Präparation der Vasa axillaria und der Faszikel des Plexus brachialis. Ligatur der in den Tumor eintretenden Gefäße. Tumorresektion, Fadenmarkierung. Rekonstruktion mittels transossärer Reinsertion des M. pectoralis minor am Processus coracoideus. Setzen von Bohrkanälen und transossäre Refixation des M. pectoralis major am Humerus.

Weiterbehandlung
Schulterabduktionskissen für 6 Wochen, passive Mobilisation Woche 6 bis 12, dann aktive Mobilisation. Kompressionsorthese. Onkologische Nachsorge.

Ergebnisse
Zwischen 2017 und 2022 erfolgte in 6 konsekutiven Fällen (4 primäre Weichteilsarkome, 2 Metastasen) die chirurgische Resektion. In 100 % der Fälle wurde eine primäre R0-Resektion erreicht. Das mittlere Follow-up lag bei 22,5 Monaten (3 bis 60 Monate), im gesamten Nachuntersuchungszeitraum traten keine Lokalrezidive auf. Der durchschnittliche Bewegungsumfang für die Abduktion im Schultergelenk lag bei 135,0 ± 41,4° (Range 90–180°). Es traten keine postoperativen sensomotorischen Defizite auf. Die subjektive Schulterfunktion lag bei 80,0 ± 21,0 % (Range 50–100 %). Der mittlere MSTS-Score lag bei 89,5 % (Range 32–100 %) und belegt somit ein gutes funktionales Outcome.
A glycomic workflow for LC–MS/MS analysis of urine glycosaminoglycan biomarkers in mucopolysaccharidoses
Authors: Nilsson Jonas , Persson Andrea , Vorontsov Egor , Nikpour Mahnaz , Noborn Fredrik , Larson Göran , Blomqvist Maria 
Published: July 2023

AbstractIn recent years, several rational designed therapies have been developed for treatment of mucopolysaccharidoses (MPS), a group of inherited metabolic disorders in which glycosaminoglycans (GAGs) are accumulated in various tissues and organs. Thus, improved disease-specific biomarkers for diagnosis and monitoring treatment efficacy are of paramount importance. Specific non-reducing end GAG structures (GAG-NREs) have become promising biomarkers for MPS, as the compositions of the GAG-NREs depend on the nature of the lysosomal enzyme deficiency, thereby creating a specific pattern for each subgroup. However, there is yet no straightforward clinical laboratory platform which can assay all MPS-related GAG-NREs in one single analysis. Here, we developed and applied a GAG domain mapping approach for analyses of urine samples of ten MPS patients with various MPS diagnoses and corresponding aged-matched controls. We describe a nano-LC–MS/MS method of GAG-NRE profiling, utilizing 2-aminobenzamide reductive amination labeling to improve the sensitivity and the chromatographic resolution. Diagnostic urinary GAG-NREs were identified for MPS types IH/IS, II, IIIc, IVa and VI, corroborating GAG-NRE as biomarkers for these known enzyme deficiencies. Furthermore, a significant reduction of diagnostic urinary GAG-NREs in MPS IH (n = 2) and MPS VI (n = 1) patients under treatment was demonstrated. We argue that this straightforward glycomic workflow, designed for the clinical analysis of MPS-related GAG-NREs in one single analysis, will be of value for expanding the use of GAG-NREs as biomarkers for MPS diagnosis and treatment monitoring.
Throwing Good Money After Bad: Risk Mitigation Strategies in the P2P Lending Platforms
Authors: Bao Tianzi , Ding Yi , Gopal Ram , Möhlmann Mareike 
Published: July 2023

AbstractThe success of peer-to-peer (P2P) lending platforms has proven inconsistent and uneven over time and geography. This paper aims to strengthen our understanding of the market evolution through an analysis of risks on P2P lending platforms, which can be significantly affected by the way the platform design, regulatory structural building, nature of the transaction, and interdependencies between organizational components. We extend the social-technical model and create a systematic framework to map and analyze the financial risks from a hybrid financial and organizational approach. By implementing textual and statistical analysis on a dataset from Renrendai platform, we found that risks are generated not only from the stakeholders but also due to the weaknesses of interdependencies between organizational components and platform design. We also utilize our models to investigate why some P2P platforms such as LendingClub and Upstart (US), Renrendai (China), and Zopa (UK) have succeeded or failed from both finance and IS perspectives, and further propose potential risk-mitigation strategies for P2P lending platforms.
Life Satisfaction During the COVID-19 Pandemic: The Role of Human, Economic, Social, and Psychological Capital
Authors: Delhey Jan , Hess Stephanie , Boehnke Klaus , Deutsch Franziska , Eichhorn Jan , Kühnen Ulrich , Welzel Christian 
Published: July 2023

AbstractA cornerstone of well-being research is that the resource-rich are happier with their lives than the resource-poor and better positioned to cope with stressful life events. This paper addresses the role of various resources—human, economic, social, and psychological capital—in life satisfaction during the coronavirus pandemic, using panel data from Germany and the United Kingdom for 2020 and 2021. Cross-sectionally, we find life satisfaction to be clearly related to all these forms of capital, with psychological capital being the strongest predictor of life satisfaction. Longitudinally, the capital endowments in 2020 did not predict changes in life satisfaction within individuals from 2020 to 2021, except for psychological capital. Our results suggest two things: first, the unfolding pandemic did not heighten well-being inequalities; and second, weathering the pandemic required psychological resources in the first place.
Local and global deference
Authors: Gallow J. Dmitri 
Published: July 2023

AbstractA norm of local expert deference says that your credence in an arbitrary proposition A, given that the expert’s probability for A is n, should be n. A norm of global expert deference says that your credence in A, given that the expert’s entire probability function is E, should be E(A). Gaifman taught us that these two norms are not equivalent. Stalnaker conjectures that Gaifman’s example is “a loophole”. Here, I substantiate Stalnaker’s suspicions by providing characterisation theorems which tell us precisely when the two norms come apart. They tell us that, in a good sense, Gaifman’s example is the only case where the two norms differ. I suggest that the lesson of the theorems is that Bayesian epistemologists need not concern themselves with the differences between these two kinds of norms. While they are not strictly speaking equivalent, they are equivalent for all philosophical purposes.