bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Media Baru Dalam Membentuk Cyber Society
Authors: Alim Puspianto  
Published: August 2023

Kita sekarang hidup di tengah tengah kemajuan dan kecanggihan teknologi yang begitu luar biasa. Satu aspek yang sangat terasa percepatan perkembangannya yaitu dibidang teknologi informasi dan komunikasi khususnya diaspek media. Bahkan kadang kita tidak bisa memprediksikan dan seakan gagap akan dahsyatnya kecanggihan teknologi yang ada. Kemajuan teknologi tersebut telah mengantarkan dan merubah “wajah” baru dunia media. Apalagi dengan kehadiran media baru yang berupa internet dan serba serbi di dalamnya seperti youtube, facebook, instagram, twiter, line dan lain sebaginya. Hal itu memunculkan sebuah tatanan dunia baru yang bernama cyber society atau masyarakat maya. Dimana interaksi dan hubungan antar manusia modern tidak hanya berada di dunia nyata saja tetapi keberadaan ruang maya menjadi sebuah keniscayaan.
Eksistesi cyber sosiety tentunya merupakan bagian tak terpisahkan dari peran media baru yang menjadi ruang hidupnya. Dimana tentunya kehadiran entitas baru ini punya perbedaan dengan kelompok kelompok masyarakat sebelumnya. Bahkan perbedaan tersebut sangatlah jelas dan terasa. Karena dizaman ini, dunia nyata hampir hampir sudah tergantikan dengan dunia maya atau cyber spacy. Kehidupan Cyber society sudah tidak lagi terhalang oleh jarak dan waktu. Dari sinilah babak baru kehidupan dimulai, dimana semua info dan berita bahkan kebutuhan hidup bisa diakses dengan mudah oleh semua orang tanpa ada sekat dan pengahalang.
Dalam tulisan ini penulis memaparkan tentang peran media baru dalam membentuk cyber sosiety atau masyarakat maya. Dimana kehadiran media baru telah merubah tatanan kehidupan seluruh masyarakat dunia.Yaitu sebuah wajah baru yang dengan kecanggihannya mampu menerobos dan merobohkan tembok tatanan kehidupan sebelumnya. Semua manusia diajak untuk hidup dalam ruang maya yang penuh dengan kemudahan dan kecanggihan.
Dari pembahasan yang disajikan, penulis menyimpulkan bahwa hadirnya media baru sangat berperan penting dalam lahirnya cyber society. Karena tanpa media baru dengan serba serbi didalamnya khsuusnya media sosial akan sangat mustahil kiranya cyber soaiety bisa terbentuk. Kehadiran cyber society menjadi sebuah wajah baru bagi tatanan kehidupan umat manusia. Tentunya tanpa menghilangkan tatanan kehidupan masyarakat sebelumnya. Dari sinilah babak baru sebuah tatanan kehidupan masyarakt dimulai.
Momentum Surat Al Lail dalam Perspektif Filsafat Bisnis
Authors: Muslimin  
Published: August 2023

Al-Lail verses and letters are important in the ranks of business verses through this verse which are able to provide new arguments in the economic scene. Al-Qur'an and Hadith are two Muslim guidelines that are interconnected with each other. The current situation and the future situation are also full of science and technology needed by mankind. So that the Qur'an and Hadith are often referred to as the source of all knowledge, including business and muamalat issues.
Some of the knowledge contained in the Qur'an is easy to understand, while others require further thought and development and reflection to be understood. One's understanding of the Qur'an depends on one's intelligence, so the same verse may give different interpretations. In this journal we discuss the relationship of Surat al-Lail on economics with its philosophy. The momentum of Surah Al-Lail is a Makiyyah letter that was revealed to the Prophet shalallahu 'alaihi wasallam before moving to the city of Medina, and the subject of this letter is related to people who donate and people who are stingy. As well as motivation for business movements with various theories and practices.
Keywords: business, philosophy and infaq.
Ayat dan surat al-Lail asupan penting dalam jajaran ayat-ayat bisnis lewat ayat ini di mana mampu memberikan dalil baru dalam belantika ekonomi. Al-Qur’an dan Hadits merupakan dua pedoman umat muslim yang saling berhubungan satu sama lain. keadaan saat ini maupun keadaan pada masa yang akan datang, juga sarat dengan ilmu pengetahuan dan teknologi yang dibutuhkan oleh umat manusia. Sehingga al-Qur'an dan Hadits sering disebut sebagai sumber segala ilmu pengetahuan termsuk masalah usaha dan muamalat.
Ilmu pengetahuan yang terdapat dalam al-Qur'an ada yang mudah dipahami ada juga yang memerlukan pemikiran dan pengembangan serta perenungan lebih lanjut untuk dapat dipahami. Pemahaman tentang al-Qur'an seseorang tergantung pada kecerdasan, sehingga dari ayat yang sama mungkin saja akan memberikan tafsiran yang berbeda.dalam jurnal ini kami membahas hubungan surat al-lail tentang ekonomi dengan filosofinya. Momentum Surat Al-Lail adalah surat Makiyyah yang diturunkan kepada Nabi shalallahu ‘alaihi wasallam sebelum berhijrah ke kota Madinah, dan pokok pembicaraan surat ini berkaitan dengan orang-orang yang berinfak dan orang-orang yang bakhil. Serta motivasi gerak usaha dengan berbagai teori dan praktek.
Signifikansi Character Building Melalui Aswaja dan Ke-NU-an Di Universitas Nahdlatul Ulama Blitar
Authors: Shofwan Arif Muzayin 
Published: August 2023

Ada banyak cara untuk membentuk karakter di dalam perguruan tinggi, salah satunya melalui Aswaja dan Ke-NU-an. Penelitian diskriptif kualitatif dengan menggunakan studi kasus dengan metode wawancara mendalam ini bertujuan menganalisis pembentukan karakter melalui Aswaja dan Ke-NU-an di Universitas Nahdlatul Ulama (UNU) Blitar. Dalam mata kuliah Aswaja dan Ke-NU-an ditemukan beberapa nilai yang mampu menjadikan mahasiswa dan sivitas akademika memiliki beberapa karakter sebagai berikut. Pertama, cinta pada Tuhan dan alam semesta, misalnya dengan direalisasikan melalui shalawatan, tahlil, manaqib, dan lainnya. Kedua, tanggungjawab, kedisiplinan, dan kemandirian, misalnya tanggungjawaab pada masalah yang berkembang di masyarakat, disiplin dalam beribadah, dan kemandirian dalam berorganisasi. Ketiga, toleransi dan cinta damai terhadap sesama dengan perilaku toleran terhadap kultur lain dan mendamaikan konflik. Keempat, baik dan rendah hati banyak dijelaskan dalam akhlak (tasawuf) salah satunya dengan tradisi mencium tangan orang tua, guru, dan ulama. Kelima, kepemimpinan dan keadilan yang diatur dalam anggaran dasar dan rumah tangga NU. Keenam, kepercayaan terhadap diri, kreatif, kerja keras, dan pantang menyerah, salah satunya dalam tekad pendirian tujuh program studi. Ketujuh, kasih sayang, kepedulian dan kerja sama diwujudkan melalui visi misi UNU. Kedelapan, hormat dan santun diwujudkan dalam sikap kemasyarakatan NU. Kesembilan, kejujuran merupakan realisasi dari sifat wajib bagi para rasul.
Le film d’archives ou l’archive du film. Retour sur Le Huitième Jour et Le Son d’un espace de Charles Gagnon
Authors: Fraser Marie 
Published: August 2023

Ce texte analyse deux films de Charles Gagnon réalisés à la fin des années 1960 : Le Huitième Jour, conçu pour le Pavillon chrétien d’Expo 67 à Montréal, et Le Son d’un espace, présenté pour la première fois dans le cadre de la Sixième Biennale de Paris, en 1969. L’étude s’appuie en grande partie sur des sources qui permettent de mieux comprendre les conditions de production et de présentation des films au moment de leur réalisation grâce notamment au Fonds d’archives Charles Gagnon récemment mis à disposition des chercheur·euse·s à Bibliothèque et Archives du Musée des beaux-arts du Canada. L’article se penche plus spécifiquement sur le double rôle de l’archive : d’une part, comme constitutive de la forme et du contenu du cinéma de réemploi (found footage) dans lequel Le Huitième Jour s’inscrit et, d’autre part, comme une façon d’exposer la matérialité filmique dans Le Son d’un espace. La réflexion est traversée par l’hypothèse selon laquelle l’archive rendrait visibles les traces matérielles du film tant au moment de la conception, du montage et de l’enregistrement qu’au moment du visionnement. Examiner ces films en parallèle permet aussi de mettre en évidence que, pour Charles Gagnon, la spécificité du cinéma est déterminée par ses supports à la fois visuel et sonore.
Análise da responsabilidade social corporativa interna na rede estadual de saúde do Maranhão
Authors: Batista Lavynia Soares , Vieira Fernando de Oliveira , Viana Rodrigo Cardoso , Monforte Tamires Morcelli , De Oliveira Juliana Leonicio Sales , Costa Ludmila Wendy Sousa 
Published: August 2023

De acordo com as estatísticas do Observatório de Saúde e Segurança do Trabalho, as atividades laborais executadas em ambiente hospitalar ocupam o 1° lugar no ranking de notificações de acidente do trabalho, além das doenças psicossomáticas que afetam grande parte dos colaboradores que prestam serviço nesta área. Embora não esteja entre os estados classificados em situação mais crítica, o Maranhão apresenta índices preocupantes com relação ao tema. Só em 2021, foram mais de 3.400 notificações de acidentes, sendo as atividades de atendimento hospitalar o setor econômico com mais casos. No intuito de identificar as políticas empregadas pelas empresas que administram os hospitais da rede pública estadual de saúde do Maranhão frente a essa realidade, realizou-se um levantamento acerca das práticas de responsabilidade social interna empregadas por essas organizações através da aplicação de um questionário baseado nos indicadores ETHOS. O mesmo dispôs de 43 perguntas relacionadas a saúde, segurança e qualidade de vida ocupacional, divididas entre questões discursivas e de múltipla escolha. Nestas últimas, adotou-se a escala de Likerth. Com o auxílio do questionário e análise inicial das respostas, pôde-se concluir que a organização entrevistada promove políticas relacionadas à responsabilidade social corporativa interna, contudo, ainda há necessidade de implementar novas ações para a melhoria das condições de saúde e segurança do trabalhador no ambiente hospitalar.
Rationality Proof of Newton's Method for Finding Quadratic Trinomial Factors of Univariate Integer Coefficient Polynomials
Authors: Yang Xintong 
Published: August 2023

The method of finding quadratic trinomial factors for univariate integer coefficient polynomials, proposed by the famous mathematician Isaac Newton in his mathematical monograph Arithmetica Universalis, is novel and concise, and has attracted the attention of mathematicians such as Leibniz and Bernoulli. However, no proof of this method has been given so far. This paper provides an in-depth analysis of this method and proves it with mathematical reasoning.Therefore, Newton's method of finding quadratic factors for univariate integer coefficient polynomials is reasonable, validate, and universal.
Prevalence of Sleep Disorders and Depression in Multiple Sclerosis and Their Management: A Literature Review
Authors: Baravi Hamsa 
Published: August 2023

This literature review concentrates on the prevalence of sleep disorders and depression in multiple sclerosis (MS) patients, as well as their effect on health and quality of life. Insomnia, sleep apnea, restless legs syndrome, and narcolepsy are some of the most common sleep disorders experienced by MS patients, according to the review. MS patients have a prevalence of sleep disturbances ranging between 29% and 66%. The review also discusses the various causes of sleep disturbances in MS patients, including physical impairment, nocturnal symptoms, adverse drug reactions, comorbid psychiatric disorders, and sleep-wake cycle abnormalities caused by neurological injury. The review highlights the need for additional research in the interconnected disciplines of sleep disorders, depression, and MS. Future research should concentrate on longitudinal studies, the explanation of underlying mechanisms, and the development of individualized therapies using innovative methodologies. By gaining a deeper understanding of and intervening in sleep disturbances and melancholy, MS patients can receive more comprehensive care.
Management of Acetaminophen Poisoning in the US and Canada
Authors: Dart Richard C. , Mullins Michael E. , Matoushek Theresa , Ruha Anne-Michelle , Burns Michele M. , Simone Karen , Beuhler Michael C. , Heard Kennon J. , Mazer-Amirshahi Maryann , Stork Christine M. , Varney Shawn M. , Funk Alexandra R. , Cantrell Lee F. , Cole Jon B. , Banner William , Stolbach Andrew I. , Hendrickson Robert G. , Lucyk Scott N. , Sivilotti Marco L. A. , Su Mark K. , Nelson Lewis S. , Rumack Barry H. 
Published: August 2023

ImportanceThe US and Canada currently have no formal published nationwide guidelines for specialists in poison information or emergency departments for the management of acetaminophen poisoning, resulting in significant variability in management.ObjectiveTo develop consensus guidelines for the management of acetaminophen poisoning in the US and Canada.Evidence ReviewFour clinical toxicology societies (America’s Poison Centers, American Academy of Clinical Toxicology, American College of Medical Toxicology, and Canadian Association of Poison Control Centers) selected participants (n = 21). Led by a nonvoting chairperson using a modified Delphi method, the panel created a decision framework and determined the appropriate clinical management of a patient with acetaminophen poisoning. Unique to this effort was the collection of guidelines from most poison centers in addition to systematic collection and review of the medical literature. Comments from review by external organizations were incorporated before the guideline was finalized. The project began in March 2021 and ended in March 2023.FindingsThe search retrieved 84 guidelines and 278 publications. The panel developed guidelines for emergency department management of single or repeated ingestion of acetaminophen. In addition, the panel addressed extended-release formulation, high-risk ingestion, coingestion of anticholinergics or opioids, age younger than 6 years, pregnancy, weight greater than 100 kg, and intravenous acetaminophen use. Differences from current US practice include defining acute ingestion as an ingestion presentation from 4 to 24 hours after overdose was initiated. A revised form of the Rumack-Matthew nomogram was developed. The term massive ingestion was replaced with the term high-risk ingestion and denoted by a specific nomogram line. Other recommendations include specific criteria for emergency department triage, laboratory evaluation and monitoring parameters, defining the role of gastrointestinal decontamination, detailed management of acetylcysteine treatment, associated adverse effects, and stopping criteria for acetylcysteine treatment, as well as criteria for consultation with a clinical toxicologist. Finally, specific treatment considerations, including acetylcysteine dosing, fomepizole administration, and considerations for extracorporeal elimination and transplant evaluation, were addressed.Conclusions and RelevanceThis qualitative study provides a consensus statement on consistent evidence-based recommendations for medical, pharmacy, and nursing education and practice to optimize care of patients with acetaminophen poisoning.
Low‐Dose Staphylococcal Enterotoxin C2 Mutant Maintains Bone Homeostasis via Regulating Crosstalk between Bone Formation and Host T‐Cell Effector Immunity
Authors: Wang Haixing , Lin Sien , Feng Lu , Huang Baozhen , Lu Xuan , Yang Zhengmeng , Jiang Zhaowei , Li Yu‐Cong , Zhang Xiaoting , Wang Ming , Wang Bin , Kong Lingchi , Pan Qi , Bai Shanshan , Li Yuan , Yang Yongkang , Lee Wayne Yuk Wai , Currie Peter D. , Lin Changshuang , Jiang Yanfu , Chen Juyu , Tortorella Micky D. , Li Hongyi , Li Gang 
Published: August 2023

AbstractStudies in recent years have highlighted an elaborate crosstalk between T cells and bone cells, suggesting that T cells may be alternative therapeutic targets for the maintenance of bone homeostasis. Here, it is reported that systemic administration of low‐dose staphylococcal enterotoxin C2 (SEC2) 2M‐118, a form of mutant superantigen, dramatically alleviates ovariectomy (OVX)‐induced bone loss via modulating T cells. Specially, SEC2 2M‐118 treatment increases trabecular bone mass significantly via promoting bone formation in OVX mice. These beneficial effects are largely diminished in T‐cell‐deficient nude mice and can be rescued by T‐cell reconstruction. Neutralizing assays determine interferon gamma (IFN‐γ) as the key factor that mediates the beneficial effects of SEC2 2M‐118 on bone. Mechanistic studies demonstrate that IFN‐γ stimulates Janus kinase/signal transducer and activator of transcription (JAK–STAT) signaling, leading to enhanced production of nitric oxide, which further activates p38 mitogen‐activated protein kinase (MAPK) and Runt‐related transcription factor 2 (Runx2) signaling and promotes osteogenic differentiation. IFN‐γ also directly inhibits osteoclast differentiation, but this effect is counteracted by proabsorptive factors tumor necrosis factor alpha (TNF‐α) and interleukin 1 beta (IL‐1β) secreted from IFN‐γ‐stimulated macrophages. Taken together, this work provides clues for developing innovative approaches which target T cells for the prevention and treatment of osteoporosis.
Dual Synergistic Tumor‐Specific Polymeric Nanoparticles for Efficient Chemo‐Immunotherapy
Authors: Xiang Jiajia , Liu Kexin , Xu Hongxia , Zhao Zhihao , Piao Ying , Shao Shiqun , Tang Jianbin , Shen Youqing , Zhou Zhuxian 
Published: August 2023

AbstractChemo‐immunotherapy has made significant progress in cancer treatment. However, the cancer cell self‐defense mechanisms, including cell cycle checkpoint and programmed cell death‐ligand 1 (PD‐L1) upregulation, have greatly hindered the therapeutic efficacy. Herein, norcantharidin (NCTD)‐platinum (Pt) codelivery nanoparticles (NC‐NP) with tumor‐sensitive release profiles are designed to overcome the self‐defense mechanisms via synergistic chemo‐immunotherapy. NC‐NP remains stable under normal physiological conditions but quickly releases 1,2‐diaminocyclohexane‐platinum(II) (DACHPt, a parent drug of oxaliplatin) and NCTD in response to the tumor acidity. NCTD inhibits protein phosphatase 2A (PP2A) activity to relieve cell cycle arrest and downregulates the tumor PD‐L1 expression to disrupt the programmed cell death‐1 (PD‐1)/PD‐L1 interaction, synergistically enhancing Pt‐based chemotherapy and immunogenic cell death‐induced immunotherapy. As a result, NC‐NP exhibits potent synergistic cytotoxicity and promotes T cell recruitment to generate robust antitumor immune responses. The dual synergism exhibits potent antitumor activity against orthotopic 4T1 tumors, providing a promising chemo‐immunotherapy paradigm for cancer treatment.
The Interaction between Macrophages and Triple‐negative Breast Cancer Cells Induces ROS‐Mediated Interleukin 1α Expression to Enhance Tumorigenesis and Metastasis
Authors: Hao Meng , Huang Bin , Wu Renfei , Peng Zheng , Luo Kathy Qian 
Published: August 2023

AbstractTriple‐negative breast cancer (TNBC) has higher mortality than non‐TNBC because of its stronger metastatic capacity. Increasing studies reported that TNBC tumors had more macrophage infiltration than non‐TNBC tumors, which promoted the metastasis of TNBC cells. However, how TNBC cells become more malignant after interacting with macrophages is less reported. In this study, it is observed that when TNBC cells are co‐cultured with macrophages, they display higher viability and stronger metastatic ability than non‐TNBC cells. Mechanistic studies reveal that TNBC cells acquired these abilities via interactions with macrophages in three phases. First, within 12 h of co‐culture with macrophages, some TNBC cells have significantly elevated levels of reactive oxygen species (ROS), which upregulate interleukin 1α (IL1α) expression in ERK1/2‐c‐Jun‐ and NF‐κB‐dependent manners at 24−48 h. Second, the secreted IL1α bound to IL1R1 activates the ERK1/2‐ZEB1‐VIM pathway which increases metastasis. Third, IL1α/IL1R1 facilitates its own synthesis and induces the expression of IL1β and IL8 at 72−96 h through the MKK4‐JNK‐c‐Jun and NF‐κB signaling pathways. Moreover, a higher level of IL1α is positively correlated with more macrophage infiltration and shorter overall survival in breast cancer patients. Thus, reducing ROS elevation or downregulating IL1α expression can serve as new strategies to decrease metastasis of TNBC.
Versatile Liquid Metal/Alginate Composite Fibers with Enhanced Flame Retardancy and Triboelectric Performance for Smart Wearable Textiles
Authors: Qi Xiulei , Liu Yide , Yu Lei , Yu Zhenchuan , Chen Long , Li Xiankai , Xia Yanzhi 
Published: August 2023

AbstractLiquid metal (LM) shows the superiority in smart wearable devices due to its biocompatibility and electromagnetic interference (EMI) shielding. However, LM based fibers that can achieve multifunctional integrated applications with biodegradability remain a daunting challenge. Herein, versatile LM based fibers are fabricated first by sonication in alginate solution to obtain LM micro/nano droplets and then wet‐spinning into LM/alginate composite fibers. By mixing with high‐concentration alginate solution (4–6 wt.%), the LM micro/nano droplets stability (colloidal stability for > 30 d and chemical stability for > 45 d) are not only improved, but also facilitate its spinning into fibers through bimetallic ions (e.g., Ga3+ and Ca2+) chelation strategy. These resultant fibers can be woven into smart textiles with excellent flexibility, air permeability, water/salt resistance, and high temperature tolerance (−196–150 °C). In addition, inhibition of smoldering result from the LM droplets and bimetallic ions is achieved to enhance flame retardancy. Furthermore, these fibers combine the exceptional properties of LM droplets (e.g., photo‐thermal effect and EMI shielding) and alginate fibers (e.g., biocompatibility and biodegradability), applicable in wearable heating devices, wireless communication, and triboelectric nanogenerator, making it a promising candidate for flexible smart textiles.
Biosynthetic Plastics as Tunable Elastic and Visible Stent with Shape‐Memory to Treat Biliary Stricture
Authors: Wang Wei , Luan Zhaohui , Shu Zhenzhen , Xu Kaige , Wang Tongchuan , Liu Shuang , Wu Xiaozhuo , Liu Hangzong , Ye Shaosong , Dan Ruijue , Zhao Xiaoyan , Yang Shiming , Xing Malcolm , Fan Chaoqiang 
Published: August 2023

AbstractCommon biliary tract is ≈4 mm in diameter to deliver bile from liver to small intestine to help digestion. The abnormal narrowing leads to severe symptoms such as pain and nausea. Stents are an effective treatment. Compared with non‐degradable stents which require repeated removal, biodegradable stents have the advantage of reducing secondary injury related to endoscopic operation and patient burden. However, current biodegradable materials may cause tissue hyperplasia and the treatment method does not target etiology of stricture. So recurrence rates after biodegradable stent implantation are still high. Here, a biodegradable helical stent fabricated from biosynthetic P(3HB‐co‐4HB) is reported. Tunable properties can be acquired through altering culture substrates. Stent shows shape memory in various solvents. The stent has an optimized design with helical structure and outer track. The self‐expanding of helical structure and double drainage realized by outer track greatly improve drainage of bile. Importantly, stent‐loading triamcinolone acetonide can inhibit proliferation of fibroblasts and reduce incidence of restricture. Therapeutic effect is also demonstrated in minipigs with biliary stricture. The results of minipig experiments show that biliary duct in treatment group is unobstructed and tissue hyperplasia is effectively inhibited.