bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid evolution and related fluid–rock interactions of the Oligocene Zhuhai sandstones in the Baiyun Sag, northern margin of the South China Sea
Authors: Tian Bing , Yuan Yihan , Tang Jun , Zuo Shanshan , Zheng Youwei , Liu Ming , Guo Cheng 
Published: August 2023

AbstractPore fluids control the diagenetic processes and storage spaces of deep clastic rock reservoirs and have become a major area of interest within the fields of sedimentology and petroleum geology. This paper aims to relate the diagenetic processes of the Oligocene Zhuhai sandstones in the Baiyun Sag to pore fluids varying with burial depth. The types and distribution patterns of authigenic minerals are investigated through analysis of petrographic, mineralogical, and geochemical features to illustrate the origin and flow patterns of pore fluids and their influences on reservoir diagenesis. Strong cementation of eogenetic carbonate cement near the sandstone–mudstone interface was a consequence of material migration from adjacent mudstones on a large scale. The pore fluids were mainly affected by microbial methanogenesis and carbonate mineral dissolution in adjacent mudstones during eogenesis. The pore fluids were diffusively transported in a relatively open geochemical system within a local range. Support for this model is provided by the heavier stable isotopic values present in eogenetic calcite and dolomite. Feldspar dissolution during early mesogenesis was spatially accompanied by the precipitation of authigenic quartz and ferroan carbonate cement. Pore fluids in this period were rich in organic acids and CO2, and their migration mechanism was diffusive transport. The obviously lighter carbon and oxygen isotopic compositions of the ferroan calcite support this inference. During late mesogenesis, the input of deep hydrothermal fluid might have been partly responsible for the precipitation of ankerite, barite and authigenic albite. Oil charging may have inhibited carbonate cementation and compaction, accordingly preserving porosity, and together with authigenic kaolinite, might have promoted the transition of the reservoir from water wet to oil wet to the benefit of oil entrapment. The findings reported here shed new light on the evaluation and prediction of sandstone reservoirs that have experienced multiple periods of fluid flow.
Fire carbon emissions over Equatorial Asia reduced by shortened dry seasons
Authors: Wang Sifan , He Bin , Chen Hans W. , Chen Deliang , Chen Yaning , Yuan Wenping , Shi Feng , Duan Jianping , Wu Wei , Chen Tiexi , Guo Lanlan , Zhong Ziqian , Duan Weili , Li Zhi , Jiang Weiguo , Huang Ling , Hao Xingming , Tang Rui , Liu Huiming , Zhang Yafeng , Xie Xiaoming 
Published: August 2023

AbstractFire carbon emissions over Equatorial Asia (EQAS) play a critical role in the global carbon cycle. Most regional fire emissions (89.0%) occur in the dry season, but how changes in the dry-season length affect the fire emissions remains poorly understood. Here we show that, the length of the EQAS dry season has decreased significantly during 1979–2021, and the delayed dry season onset (5.4 ± 1.6 (± one standard error) days decade−1) due to increased precipitation (36.4 ± 9.1 mm decade−1) in the early dry season is the main reason. The dry season length is strongly correlated with the length of the fire season. Increased precipitation during the early dry season led to a significant reduction (May: −0.7 ± 0.4 Tg C decade−1; August: −12.9 ± 6.7 Tg C decade−1) in fire carbon emissions during the early and peak fire season. Climate models from the Coupled Model Intercomparison Project Phase 6 project a continued decline in future dry season length in EQAS under medium and high-emission scenarios, implying further reductions in fire carbon emissions.
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
Authors: Okreglak Voytek , Ling Rachel , Ingaramo Maria , Thayer Nathaniel H. , Millett-Sikking Alfred , Gottschling Daniel E. 
Published: August 2023

Abstract
Amino acid homeostasis is critical for many cellular processes. It is well established that amino acids are compartmentalized using pH gradients generated between organelles and the cytoplasm; however, the dynamics of this partitioning has not been explored. Here we develop a highly sensitive pH reporter and find that the major amino acid storage compartment in Saccharomyces cerevisiae, the lysosome-like vacuole, alkalinizes before cell division and re-acidifies as cells divide. The vacuolar pH dynamics require the uptake of extracellular amino acids and activity of TORC1, the v-ATPase and the cycling of the vacuolar specific lipid phosphatidylinositol 3,5-bisphosphate, which is regulated by the cyclin-dependent kinase Pho85 (CDK5 in mammals). Vacuolar pH regulation enables amino acid sequestration and mobilization from the organelle, which is important for mitochondrial function, ribosome homeostasis and cell size control. Collectively, our data provide a new paradigm for the use of dynamic pH-dependent amino acid compartmentalization during cell growth/division.
Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma
Authors: Zheng Chunxing , Snow Bryan E. , Elia Andrew J. , Nechanitzky Robert , Dominguez-Brauer Carmen , Liu Shaofeng , Tong Yin , Cox Maureen A. , Focaccia Enrico , Wakeham Andrew C. , Haight Jillian , Tobin Chantal , Hodgson Kelsey , Gill Kyle T. , Ma Wei , Berger Thorsten , Heikenwälder Mathias , Saunders Mary E. , Fortin Jerome , Leung Suet Yi , Mak Tak W. 
Published: August 2023

AbstractCholinergic nerves are involved in tumor progression and dissemination. In contrast to other visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It remains unclear whether there is any form of cholinergic regulation of liver cancer. Here, we show that cholinergic T cells curtail the development of liver cancer by supporting antitumor immune responses. In a mouse multihit model of hepatocellular carcinoma (HCC), we observed activation of the adaptive immune response and induction of two populations of CD4+ T cells expressing choline acetyltransferase (ChAT), including regulatory T cells and dysfunctional PD-1+ T cells. Tumor antigens drove the clonal expansion of these cholinergic T cells in HCC. Genetic ablation of Chat in T cells led to an increased prevalence of preneoplastic cells and exacerbated liver cancer due to compromised antitumor immunity. Mechanistically, the cholinergic activity intrinsic in T cells constrained Ca2+–NFAT signaling induced by T cell antigen receptor engagement. Without this cholinergic modulation, hyperactivated CD25+ T regulatory cells and dysregulated PD-1+ T cells impaired HCC immunosurveillance. Our results unveil a previously unappreciated role for cholinergic T cells in liver cancer immunobiology.
Promising Strategies for Teaching Augmentative and Alternative Communication in Inclusive Educational Settings: A Systematic Review
Authors: O'Regan Kleinert Jane , Kearns Jaqueline F. , Page Judith L. , Kleinert Harold L. 
Published: August 2023

Purpose:
The purpose of this article was to conduct a systematic review of the literature on teaching or increasing the use of augmentative and alternative communication (AAC) by students with significant intellectual disabilities and complex communication needs (CCNs) within inclusive school settings.

Method:
A systematic review of research literature from 1998 to 2022 was completed using multiple electronic databases, as well as citation chaining and cited author reference searches. Three hundred two articles were located with 17 meeting criteria for inclusion in this systematic review. Articles were initially screened by one author for potential inclusion; the remaining 83 were coded by one author and reviewed for consensus by three authors for inclusion in this review. Articles were analyzed and rated regarding both level of research design and quality of methodology.

Results:
All studies reported positive outcomes, with students with significant intellectual disabilities and CCN, of AAC intervention implemented in an inclusive setting. Fourteen over 17 studies were single-case designs with an average rating of 76% on the Single-Case Experimental Design measure of methodological quality. Less than half of the studies assessed generalization of subject learning. Review of interventions used in the studies, however, revealed the majority of studies utilized packages of interventions, making it difficult to determine the effectiveness of individual approaches.

Conclusions:
This systematic review indicates there are promising interventions within inclusive settings for improved use of AAC by students with significant intellectual disabilities and CCN. Further research is needed, however, to obtain more data on generalization of student gains as well as to determine which specific interventions might be the most successful for this population of students in inclusive settings.
A low sidelobe 77 GHz centre‐fed microstrip patch array antenna
Authors: Chen Qian , Yan Songlin , Guo Xinyue , Wang Wei , Huang Zhixiang , Yang Lixia , Li Yingsong , Liang Xianling 
Published: August 2023

AbstractA low sidelobe 77 GHz centre‐fed microstrip patch array antenna is proposed for automotive radar application. The proposed antenna comprises eight linear antenna arrays, each of which is centre‐fed by a coplanar waveguide with ground transmission line at the back of the microstrip patches. Each linear antenna array contains 10 patch antenna units, which are connected through a T‐type power divider network to achieve a −30 dB Taylor weighted distribution. The simulation results show that the designed phased array antenna has a good one‐dimensional phased scanning ability of ±45° with active voltage standing wave ratio less than 2 at 75–79 GHz, along with −20 dB low sidelobe symmetrical radiation patterns in the H plane. An antenna sample fed by a WR12 waveguide is fabricated and measured to verify its performance. The measured VSWR is less than 2 at 73.6–85 GHz. This design provides a new idea for millimetre wave automotive radar antenna design.
An Investigation of the BentleyR Gas-STATTM Monitoring System GSM-100
Authors: Gefke Kaj , Waaben Jens , Andersen Lars I. , Löwenmark Anette , Sørensen Hans R. , Husum Bent 
Published: August 2023

(J. Extra-Corpor. Technol. 20(2):59-62) The BentleyR Gas-STAT™ monitoring system GSM-1 00 (GSM) is an optical fluoroscence microsensing system with a sensor placed in the extracorporeal circuit. It measures blood temperature and analyses oxygen tension, carbon dioxide tension, and pH at the actual blood temperature, and the results may be converted to values at 37°C.
In 6 pigs subjected to cardiopulmonary bypass at 28°C and 37°C, this system was compared to the Radiometer Acid-Base Laboratory-2 blood gas analyser (ABL-2). A total of 102 blood samples were drawn from the arterial and venous lines of the circuit next to the GSM sensors, and simultaneously the GSM readings were recorded. The samples were analyzed by the ABL-2 at 37°C, and the results were converted to the actual temperature by the apparatus.
Statistical evaluation was performed by a linear regression model of ABL-2 readings on GSM readings. From preliminary analyses of the results, it appeared that for each of the three parameters all the data might be pooled into one regression.
The results indicated that the agreement between ABL-2 readings and GSM readings with respect to pO2 and pCO2 were only fair though not clinically acceptable. The correlation between GSM readings and ABL-2 readings of pH were poor and the GSM readings without clinical relevance.
Comparison of Arterial Oxygen Tension with Continuous lranscutaneous and Intravascular PO2 Sensors and Intermittent Blood Samples Taken from the Sampling Port of a Bubble Oxygenator
Authors: Rithalia Shyam VS , Tinker Jack 
Published: August 2023

Measurements of transcutaneous PO2 (tc PO2), intraarterial PO2(PiO2) and PO2 of blood samples taken from the sampling port of the oxygenator (PoO2) were compared with arterial blood PO2 (PaO2) in 16 adult patients undergoing cardiopulmonary bypass. tcPO2 and PiO2 were recorded continuously using Roche-Kontron electrodes. PoO2 and PaO2 were measured intermittently on a Radiometer ABL2 blood gas analyser.
A total of 86 observations were made on the 16 patients. The correlation coefficient (r) between transcutaneous and arterial PO2 was 0.69 (p<0.001). The relationship between PoO2 and PaO2 was poor (r = 0.45, p<0.01). The intra-arterial electrode readings showed no significant difference with the PO2 measured on arterial blood samples (r=0.99, p<0.001).
Use of the Bio-Medicus“ Pump in Conjunction with the Argyle Gott™ TDMAC Shunt During Repair of an Atherosclerotic Aneurysm of the Descending Thoracic Aorta
Authors: Straker John W , Willett Richard P , Carlson David , Williams James 
Published: August 2023

A Bio-Medicus™ pump with a model 600 cone and flow probe was used in combination with an Argyle Gott™ TDMAC shunt on a patient suffering from an atherosclerotic aneurysm of the descending thoracic aorta. After a simple set-up and priming procedure with Normosol™ R (pH 7.4), the circuit was connected to the patient and partial bypass was initiated. Perfusion flows were maintained at approximately 1.2 liters/min/M2 • Activated clotting times were maintained at 150-250 seconds.
Upon completion of the surgical procedure, partial bypass was terminated with no difficulty to the patient. There was no evidence of fibrin formation in the circuit. Post-bypass and post-operative courses were uneventful. Because of the ease of set-up and increased flexibility of controlling flow rates through the shunt, we recommend consideration of this technique for repairs of descending thoracic aortic aneurysms.
Molekulare Diagnostik und Therapie des Differenzierten Schilddrüsenkarzinoms
Authors: Ruf Juri , von Daak Frederik , Dierks Christine 
Published: August 2023

ZusammenfassungZusammenfassend ergeben sich somit eine Vielzahl an Therapiemöglichkeiten für
radiojodrefraktäre differenzierte Schilddrüsenkarzinome (Abb. 1). Primär kann durch eine gezielte Redifferenzierungstherapie eine erneute
Radiojodtherapie ermöglicht werden. Des Weiteren stehen mit Sorafenib und Lenvatinib in der
Erstlinie der medikamentösen Systemtherapien 2 effektive VEGFR-Inhibitoren zur Verfügung.
Lenvatinib wird hierbei als wirksamer angesehen. Bei Versagen von Sorafenib ist der Wechsel
auf den noch breiter wirksamen VEGFR/FGFR-Inhibitor Lenvatinib sinnvoll. Bei Progress auf
Lenvatinib ist eine molekulare Diagnostik mittels frischer Biopsie notwendig, um spezifische,
medikamentös angehbare Läsionen wie BRAF-V600E-, RET- und NTRK-Fusionen zu identifizieren und
mittels spezifischer Inhibitoren zu blockieren. Bei Fehlen spezifischer Treibermutationen
stehen als Salvage-Therapien Cabozantinib oder die Hinzunahme eines Immuncheckpoint-Inhibitors
zur Verfügung.
Schilddrüsenfunktionsstörungen im Alter
Authors: Iwen Alexander 
Published: August 2023

ZusammenfassungSchilddrüsenfunktionsstörungen sind verbreitete Erkrankungen, mit der hohen
Lebenserwartung in Europa steigt auch die Anzahl älterer Patienten. Die Physiologie der
Schilddrüsenhormone und deren Regulation verändert sich mit zunehmendem Alter, hierbei ist die
Veränderung der Thyreoidea-stimulierendes Hormon (TSH)-Sekretion die klinisch relevanteste,
gleichzeitig werden nicht in allen Laboren altersabhängige Referenzbereiche angegeben. Ältere
Patienten haben auch öfter Begleiterkrankungen und Schilddrüsenfehlfunktionen haben einen
negativen Einfluss aus diese, insbesondere auf kardiovaskuläre Erkrankungen. Während es klare
Indikationen für die Behandlung manifester Hyperthyreosen und Hypothyreosen gibt, werden bei latenten Schilddrüsendysfunktionen altersabhängige Behandlungsempfehlungen gegeben. Die
European Thyroid Association rät bei Patienten die älter als 65 Jahre sind und an einer
latenten Hyperthreose leiden zu einem TSH-Spiegel von 0,1mU/l als Grenzwert: Bei einem
TSH-Wert <0,1mU/l besteht eine eindeutige Indikation für eine Therapie, bei einer
TSH-Konzentration >0,1mU/l wird eine relative Therapieindikation gesehen. Patienten über 65
Jahre mit einer latenten Hypothyreose und einem TSH-Wert >10mU/l sollten therapiert werden,
insbesondere wenn sie kardiovaskuläre Begleiterkrankungen haben. Die Therapie muss bei diesen
Patienten gut überwacht werden, da eine Levothyroxin-Überdosierung ebenfalls schädlich ist.
Bei Patienten mit einer latenten Hypothyreose und einem TSH-Wert zwischen 7 und 10mU/l gibt es
hingegen keine eindeutige Indikation für eine Therapie mit Levothyroxin, weil eine solche
Therapie weder positive Effekte auf Mortalität und Morbidität noch auf die Lebensqualität hat.
Electronic Health Record Adolescent Confidentiality in a Safety Net Setting
Authors: You Jacqueline Guan-Ting , Potter Julia Esther , Mishuris Rebecca Grochow 
Published: August 2023

Abstract
Background The 21st Century Cures Act provides improved access to one's medical record but presents new challenges to adolescent confidentiality in the domain of health care information technology. Adolescent patients, who have the right to confidential care in certain areas as dictated by state law, face the prospect of parents and guardians erroneously accessing their confidential health information.
Objectives Our institution, the largest safety net hospital in our region, sought to quantify the proportion of adolescent patient portal accounts likely being accessed by guardians and to implement corrective measures for the patient portal sign-up process in our electronic health record (EHR) system.
Methods We manually reviewed our institution's adolescent patient portal accounts based on email addresses associated with adolescents' accounts. We implemented EHR changes to address the potential for breach of confidentiality as a result of adolescent patient portal account creation by guardians. One intervention was creating a “guardrail rule” to prevent guardians from creating adolescent patient portal accounts with their own email addresses. After email reminders to adolescent patients to update their accounts, we deactivated accounts with concern for erroneous guardian access.
Results Sixty percent of our institution's adolescent patient portal accounts had possible direct access by guardians. Following requests to update account access, 425 (18.8%) of accounts had email addresses updated by adolescent patients and 1,830 (81.2%) accounts were deactivated.
Conclusion More nuanced EHR functionality for adolescent patients and their guardians can help health care systems provide confidential, patient-centered care for adolescents, while allowing guardians to access appropriate health information to facilitate care. There is an opportunity for a national consensus on how adolescents and their guardians can access health information by patient portal.
Safety and Pitfalls of Blepharoptosis Surgery in Elderly People
Authors: Shirakawa Yuji , Uemura Kazuhisa , Kumegawa Shinji , Ueno Kazuki , Iwanishi Hiroki , Saika Shizuya , Asamura Shinichi 
Published: August 2023

Abstract
Background Elderly patients often have complications of blepharoptosis surgery that can result in the appearance or exacerbation of superficial punctate keratopathy (SPK). However, postoperative changes to SPK status have not been previously reported. We used subjective assessment of symptoms and measurement of SPK scale classification to investigate the safety and efficacy of blepharoptosis surgery in elderly patients.
Methods Included in this prospective study were 22 patients (44 eyes) with bilateral blepharoptosis that underwent surgery. Patients comprised 8 males and 14 females with a mean (±standard deviation) age of 75.7 ± 8.2 years (range: 61–89). Blepharoptosis surgery consisted of transcutaneous levator advancement and blepharoplasty including resection of soft tissue (skin, subcutaneous tissue, and the orbicularis oculi muscle). Margin reflex distance-1 (MRD-1) measurement, a questionnaire survey of symptoms and SPK scale classification, was administered preoperatively and 3 months postoperatively for evaluation.
Results The median MRD-1 was 1 mm preoperatively and 2.5 mm postoperatively, representing a significant postoperative improvement. SPK area and density scores were found to increase when the MRD-1 increase was more than 2.5 mm with surgery. All 10 items on the questionnaire tended have increased scores after surgery, and significant differences were observed in 7 items (poor visibility, ocular fatigue, heavy eyelid, foreign body sensation, difficulty in focusing, headaches, and stiff shoulders).
Conclusion Blepharoptosis surgery was found to be a safe and effective way to maintain the increase in MRD-1 within 2.0 mm. Despite the benefits, surgeons must nonetheless be aware that blepharoptosis surgery is a delicate procedure in elderly people.
Release of Severe Postburn Neck Contractures Under Local Anaesthesia and Ketamine
Authors: Dalal M D , Daver B M , Dalal S P 
Published: August 2023

SummarySeventeen severe postburn neck contractures were released under local infiltration anaesthesia and intravenous ketamine and split skin grafted. This anaesthetic technique obviates the need for endotracheal intubation which is difficult in such patients. Anaesthesia was sufficient for the procedure, blood loss was minimal and there was no graft loss. One patient had emergence phenomenon and there were no other complications attributable to the procedure.
Adaptive backstepping fuzzy synchronization control of fractional-order chaotic systems with input saturation and external disturbances
Authors: Lin Ming , Zhang Xiulan , Qiu Huiming 
Published: August 2023

In this paper, an adaptive backstepping command filtered controller is proposed for a class of uncertain strict feedback fractional-order chaotic systems with input saturation and external disturbances. A command filter is designed to avoid the “explosion of complexity” problem in the conventional backstepping technique. To tackle with filter error and improve synchronization accuracy, a compensation mechanism is provided. Meanwhile, fuzzy logic systems are utilized to approximate unknown functions, and disturbance observers are constructed to reduce the impact of unknown disturbances. In particular, to reduce the chattering phenomenon, a smooth function rather than the sign function is used in the controller design, and the stability of the closed-loop system can be guaranteed by the proposed synchronization controller. A simulation study is provided to confirm the practicality and validity of the proposed method.
Contactless measurement of minority carrier lifetime and background carrier concentration in unintentionally doped GaAsSb for short-wave infrared detection
Authors: Arquitola A. M. , Lee S. , Jung H. , Nooman N. , Krishna S. 
Published: August 2023

Transient microwave reflectance (TMR) measurements are used to characterize the minority carrier lifetime and background carrier concentration of unintentionally doped (UID) Ga0.5As0.5Sb lattice matched to InP at room temperature. A p-i-n sample is measured, with UID GaAsSb as the intrinsic absorber. In addition to UID GaAsSb, we determine the minority carrier lifetime and doping concentration of a buried doped n+ GaAsSb layer. The measured minority carrier lifetimes are 20.5 ± 6.3 and 0.56 ± 0.23 µs for UID and doped GaAsSb, respectively, and comparable to that of lattice matched InGaAs. For both layers, the dominant recombination mechanisms are Shockley–Read–Hall (SRH) and Auger mechanisms. The measured background carrier concentrations are in good agreement with capacitance–voltage (C–V) measurements, with n0 = 1.81 ± 0.61 × 1015 cm−3 by TMR and n0 = 1.5 × 1015 cm−3 by C–V measurements for the UID layer and ND = 5.18 ± 1.42 × 1017 cm−3 by TMR and ND = 3–4 × 1017 cm−3 by C–V measurements for the doped layer. An absorber-only structure was also measured, and we report the SRH lifetime, radiative coefficient, and Auger coefficient for this sample.