bluuebunny/crossref_metadata_2025_split huggingface dataset:
Princípios e práticas na digitalização das operações de saúde em um complexo hospitalar privado
Authors: Souza Davenilcio Luiz , Ackermann Andres Eberhard Friedl , Korzenowski André Luis , Sperafico João Henrique 
Published: August 2023

A pressão orçamentária imprime ao segmento da saúde o potencial da Indústria 4.0 para organizar a cadeia de valor em melhorias de eficiência e eficácia. Derivado da indústria 4.0, o conceito da Heath 4.0 tem foco na progressiva virtualização de serviços a pacientes, profissionais e demais envolvidos no processo do cuidado. As tecnologias habilitadoras da Heath 4.0 impulsionam tratamentos em tempo real, personalizados em análises e diagnósticos instantâneos. Este estudo propõe descrever a implementação da digitalização nas operações de um complexo hospitalar brasileiro e relacioná-las aos princípios da Heath 4.0. A metodologia utilizada na pesquisa segue o processo de busca e descrição do ambiente de estudo, com a orientação pelos recursos implementados nas rotinas e no fluxo de atendimento ao paciente em um hospital privado na região sul do Brasil. Ao analisar os conceitos, princípios e tecnologias da indústria e da Heath 4.0 é possível relacioná-los às práticas aplicadas na organização hospitalar. Houve ganhos de capacidade e de produtividade no atendimento em razão do aumento do nível de confiabilidade nos dados, obtidos pela digitalização de prontuários, interoperação entre dispositivos, redução de erros na medicação, acompanhamento eficiente do fluxo do paciente, satisfação dos profissionais de saúde e de pacientes
Artificial Intelligence (AI) in pediatric endocrinology
Authors: Winkelman Jeremy , Nguyen Diep , vanSonnenberg Eric , Kirk Alison , Lieberman Steven 
Published: August 2023

Abstract
Artificial Intelligence (AI) is integrating itself throughout the medical community. AI’s ability to analyze complex patterns and interpret large amounts of data will have considerable impact on all areas of medicine, including pediatric endocrinology. In this paper, we review and update the current studies of AI in pediatric endocrinology. Specific topics that are addressed include: diabetes management, bone growth, metabolism, obesity, and puberty. Becoming knowledgeable and comfortable with AI will assist pediatric endocrinologists, the goal of the paper.
Heraclitus on the Question of a Common Measure
Authors: Feldman Sarah 
Published: August 2023

AbstractThis paper offers a new reading of Heraclitus fragment B90 (Diels-Kranz). It argues that we can enrich our understanding of the fragment by reading it, not as a primitive analogy, but as a skillful simile grounded both in the poetic tradition and in the cultural context that would have conditioned its significance for Heraclitus and his audience. Read in this way, B90’s evocation of a cosmos whose common measure parallels the common measure of the polis’ marketplace is not simply a source of cosmological doctrine. It is also an epistemic challenge that threatens to undermine the very possibility of cosmology.
Between Poetry, Philosophy and Medicine: Body, Soul and Dreams in Pindar, Heraclitus and the HippocraticOn Regimen.
Authors: Ciampa Chiara Raffaella 
Published: August 2023

AbstractThe paper explores the interrelations between Pindar, Heraclitus and the Hippocratic author with regard to ideas of the body, the soul and dreams. I shall consider Pindar’s fr.131b as an overlooked testimony of the poet’s interest in a non-Homeric conceptualization of the soul. I will suggest reading Heraclitus’ fragments B26 and B21 together and offer a new interpretation of the latter. Furthermore, I will compare Pindar’s fr. 131b with the HippocraticOn Regimen(4. 86, 87) and Pindar’s fr. 133 withOn Regimen(4. 92) respectively, in order to highlight unnoticed similarities.
Paraventricular ThalamicMC3RCircuits Link Energy Homeostasis with Anxiety-Related Behavior
Authors: Cho Dajin , O'Berry Kyle , Possa-Paranhos Ingrid Camila , Butts Jared , Palanikumar Naraen , Sweeney Patrick 
Published: August 2023

The hypothalamic melanocortin system is critically involved in sensing stored energy and communicating this information throughout the brain, including to brain regions controlling motivation and emotion. This system consists of first-order agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) neurons located in the hypothalamic arcuate nucleus and downstream neurons containing the melanocortin-3 (MC3R) and melanocortin-4 receptor (MC4R). Although extensive work has characterized the function of downstreamMC4Rneurons, the identity and function ofMC3R-containing neurons are poorly understood. Here, we used neuroanatomical and circuit manipulation approaches in mice to identify a novel pathway linking hypothalamic melanocortin neurons to melanocortin-3 receptor neurons located in the paraventricular thalamus (PVT) in male and female mice.MC3Rneurons in PVT are innervated by hypothalamic AgRP and POMC neurons and are activated by anorexigenic and aversive stimuli. Consistently, chemogenetic activation of PVTMC3Rneurons increases anxiety-related behavior and reduces feeding in hungry mice, whereas inhibition of PVTMC3Rneurons reduces anxiety-related behavior. These studies position PVTMC3Rneurons as important cellular substrates linking energy status with neural circuitry regulating anxiety-related behavior and represent a promising potential target for diseases at the intersection of metabolism and anxiety-related behavior such as anorexia nervosa.SIGNIFICANCE STATEMENTAnimals must constantly adapt their behavior to changing internal and external challenges, and impairments in appropriately responding to these challenges are a hallmark of many neuropsychiatric disorders. Here, we demonstrate that paraventricular thalamic neurons containing the melanocortin-3 receptor respond to energy-state-related information and external challenges to regulate anxiety-related behavior in mice. Thus, these neurons represent a potential target for understanding the neurobiology of disorders at the intersection of metabolism and psychiatry such as anorexia nervosa.
Corticoesteroide oral vs. intrarticular en el tratamiento de la capsulitis adhesiva
Authors: Torres Byron , Chaves Lara Carlos 
Published: August 2023

Introducción: La capsulitis adhesiva es una enfermedad que se caracteriza por el engrosamiento de la cápsula articular del hombro, lo que se traduce clínicamente en dolor y una pérdida progresiva de la movilidad. El tratamiento conservador es la primera opción. En este estudio, se evaluó el uso de corticoesteroides articulares para el manejo de este cuadro.
Materiales y Métodos: Se llevó a cabo un estudio retrospectivo entre 2015 y 2020. Se evaluaron los registros de consulta externa de pacientes con diagnóstico de capsulitis adhesiva u hombro congelado, que recibieron tratamiento con corticoesteroides por vía oral o articular.
Resultados: Se analizó a 19 pacientes, 8 recibieron tratamiento por vía oral y 11, por vía articular. Hubo una mejoría importante en ambos grupos, pero los pacientes que recibieron corticoesteroides articulares comunicaron una mejoría a largo plazo.
Conclusiones: La administración de corticoesteroides tanto por vía oral como articular para tratar la capsulitis adhesiva fue eficaz; sin embargo, a largo plazo, los corticoesteroides articulares resultaron más eficaces.
Changes in tourist traffic during the pandemic based on the example of Podhorce Castle, according to the residents in the Lviv Oblast
Authors: Petrovets Vasylyna 
Published: August 2023

Research objective: The article deals with changes in tourism during the COVID-19 pandemic using the example of Olesko Castle. The writing of the article was undertaken by the authors in October 2021. The purpose of writing the article is to answer the questions: To what extent has the frequency of visits to Podhorce castle, by residents of Lviv region, domestic and foreign tourists, changed? In which tourist base did the changes introduced during the pandemic have the strongest impact on changes in the frequency of visits to Podhorce castle? What limiting factor will most affect changes in the frequency of visits to Podhorce castle at each tourist development base?
Methodology: The research in question used a subjective method. A survey questionnaire created by the author of the article was used as a research tool to collect relevant data. Before starting the survey, each respondent was able to read a brief information about the purpose of the research and the results obtained, which were used exclusively to write the article. Participation in the survey was voluntary. The research used a questionnaire consisting of three substantive parts.
Main conclusions: Residents of the Lviv region significantly reduced their visits to Podhorce castle during the COVID-19 pandemic. Changes made to the transport base during the pandemic had the strongest impact on changes in the frequency of visits to Podhorce castle. Of greatest importance as a limiting factor in the transport base of the city of Podhorce during the pandemic is the poor condition of access roads and the temporary suspension of domestic and foreign transport links.
Application of the study: The research can be used by units organizing and supervising tourist traffic in the Lviv region. The data of the study can serve as a basis for strategic decisions on tourist traffic in emergency situations in the Lviv region.
Originality/Novelty of the study: While writing the article, the author was guided by the timeliness and orginality of the problem. Similar research has not been conducted before in the study area.
Suture Anchor Fixation for Lunate Osteochondral Shear Fracture
Authors: Solano Mitchell A. , Morell Sean M. 
Published: August 2023

Case:
A 26-year-old right-hand–dominant man sustained a left transradial, translunate perilunate injury after motor vehicle collision. The proximal lunate fractured a primarily cartilaginous 15 × 15 mm osteochondral shear fragment with 40% articular surface involvement. A novel lunate fracture suture anchor fixation technique is described, which led to fracture healing. The radial styloid was treated with a single screw.

Conclusion:
Translunate perilunate injuries involving the lunate proximal articular surface are rare. Treatment recommendations are limited to case reports. Suture anchor fixation led to stable fixation and fracture healing at the final 6-month postoperative follow-up.
Factors of cyclone disaster deaths in coastal Bangladesh
Authors: Alam Edris 
Published: August 2023

Abstract

Bangladesh’s success in disaster risk management is often evidenced by referencing the reduction of deaths by tropical cyclones ࣧ the Cyclone Gorky 1991 took 147,000 deaths, the Cyclone Sidr 2007 took 4500 deaths and only 6 deaths by the Cyclone Mora in 2017. This raises questions of how deaths occurred by tropical cyclones in the past and what factors contributed to the reduction in deaths in the last two decades? This study answers this question by face-to-face interviews with 362 residents, field visits and observations in coastal Bangladesh. The findings indicate that there have been improvements in house structures and design, warning responses and evacuation to public cyclone shelters and informal cyclone shelter centres. In the past, due to a lack of built infrastructure, strong residential houses and public cyclone shelters, deaths occurred whilst living in fragile houses; attempting to survive through holding trees and floating in storm surges. The top ten factors that may still cause deaths by tropical cyclones include: (1) Living in fragile houses along the coast without embankment; (2) the repeat of a 1991-like cyclone; (3) non-evacuation following early warning; (4) poor roads in remote areas; (5) distance to and insufficient number of public cyclone shelters; (6) lack of protective measures for the rising number of elderly and disabled people; (7) community’s unawareness; (8) communication failure during the disaster period; (9) failure to evacuate people from remote locations; and (10) Poor radio signal and mobile network problems resulting in no warning information. This study provides several key recommendations addressing these factors of deaths, to be implemented by individual, community, private sectors, non-government organisations (NGOs) and public sectors on coastal Bangladesh.
The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial
Authors: Malamud Jolanda , Lewis Gemma , Moutoussis Michael , Duffy Larisa , Bone Jessica ,   Ramya Srinivasan3, Lewis Glyn , Huys Quentin 
Published: August 2023

Abstract

Background: Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for depression and anxiety. However, little is known about how pharmacological action is related to cognitive and affective processes. Here, we examine whether specific reinforcement learning processes mediate the treatment effects of SSRIs.
Methods: The PANDA trial was a multicentre, double-blind, randomized clinical trial in UK primary care comparing the SSRI sertraline with placebo for depression and anxiety. Participants (N=655) performed an affective Go/NoGo task three times during the trial and computational models were used to infer reinforcement learning processes.
Results: There was poor task performance: only 54% of the task runs were informative, with more informative task runs in the placebo than the active group. There was no evidence for the preregistered hypothesis that Pavlovian inhibition was affected by sertraline. Exploratory analyses revealed that in the sertraline group, early increases in Pavlovian inhibition were associated with improvements in depression after 12 weeks. Furthermore, sertraline increased how fast participants learned from losses and faster learning from losses was associated with more severe generalised anxiety symptoms. Conclusions: The study findings indicate a relationship between aversive reinforcement learning mechanisms and aspects of depression, anxiety, and SSRI treatment, but these relationships did not align with the initial hypotheses. Poor task performance limits the interpretability and likely generalizability of the findings, and highlights the critical importance of developing acceptable and reliable tasks for use in clinical studies.
Funding: This article presents research supported by NIHR Program Grants for Applied Research (RP-PG-0610-10048), the NIHR BRC, and UCL, with additional support from IMPRS COMP2PSYCH (JM, QH) and a Wellcome Trust grant (QH).
Modeling and Prediction of Embarkment Dam Displacement under Earthquake Loading Using PSO-ANN
Authors: Mostafaei Yashar , kutanaei saman soleimani 
Published: August 2023

Abstract

Evaluation of embankment dam displacement (D) under earthquake loading can contribute to safe design of the dam. Due to the complexities encountered when modeling this problem, soft computing can be seen as an appropriate solution for predicting the embarkment dam displacement under earthquake loading. In this research, ANN and PSO were integrated in an attempt to present a relationship for predicting the displacement of embankment dam (D). for this purpose, data from 102 real cases was utilized. Input parameters included the height (H) and natural period of the dam (Td), minimum required yield acceleration to slide a block of the dam body (ay), and magnitude (Mw), dominant frequency (Tp), and peak acceleration (amax) of the earthquake. It was figured out that PSO-ANN outperforms PSO in estimating earthquake-induced dam displacement. Compared to other soft-computing methods for predicting embankment dam displacement under earthquake loading, the hybrid PSO-ANN rendered more powerful and suitable.
Assessing the Socio-Environmental Challenges by Floods in 2017: A Case from a Upazila of Northern Bangladesh
Authors: Ghosh Biddut Kumar 
Published: August 2023

Abstract
Flood in Bangladesh is a very common issue regarding crossing many rivers, and raining a lot caused by monsoon wind are subject to inundation by overflow. This paper mainly focuses on the challenges associated with 2017 flood disaster in northern Bangladesh, impacts and how affected victim Households (HHs) survive with this disaster. This study is based on mixed methods, and entirely primary data are collected from seventy-three sample survey, six Focus Group Discussion (FGD) and observation. For instance, secondary data are obtained from various authorized sources. Northern Bangladesh is more vulnerable to climatic variability, flash flood, upstream heavy rainfall, early flood during pre-monsoon period, two or three times flooding at a certain year and poverty as well. The socio-economic conditions of the 2017 flood victim HHs in northern Bangladesh are sub-standard compare to other regions of Bangladesh. In addition, the 2017 flood damaged different infrastructures, institutions, properties, crops, homestead vegetation, livestock and poultry and etc. Therefore, social and economic security, and proper guidance has to be ensured, damaged infrastructures and institutions have to be rebuilt, public awareness must be increased, regional planning and delta planning have to maintained regarding the flood management for the vulnerable groups.
Numerical investigation of in-line and staggered fins arrangements on liquid mixer
Authors: Tan Sak Jie , Yu Kok Hwa , Ismail Mohd Azmi , Goh Choon Fu , Lua Kim Boon 
Published: August 2023

Abstract
This paper numerically analyzed the liquid mixing performance of a T-mixer having fins in two distinct arrangements, i.e., in-line and staggered. The effects of fin arrangements on the liquid flow characteristics in the mixing channel are assessed, and it can be profoundly indicated that the induced transverse flow tends to promote better liquid mixing. Comparatively, a mixer with a staggered fin arrangement yields superior mixing performance than that of an in-line fin arrangement, owing to a greater transverse flow. This forces the bulk of the liquid to flow alternatively through both halves of the mixing channel. Supplementary to the better mixing performance attained, a mixer with staggered fins also yields a lower pressure drop. When fins are placed perpendicular to the axial flow direction (i.e., \(\theta ={0}^{0}\)), the pressure drop yielded by in-line fin arrangement is remarkably high (> 60 times that of the basic T-mixer and > 6 times than that of the staggered fin arrangement). The superiority of the staggered fins on liquid mixing is also observed for flows at different Reynolds numbers, ranging from 0.1 to 10.
Recent Tremors in Bangladesh Might Hint at Bigger Quakes: A Probabilistic Approach for Earthquake Prediction
Authors: Ahmed Zihad , Ali Md. Rayhan , Mahmud Hasan , Muntakim Nafia , Hasan Nahid , Aziz Md. Abdul , Rahman Md. Mizanoor 
Published: August 2023

Abstract

The study performs a temporal probabilistic analysis of earthquakes in a seismically active region like Bangladesh. Data from the USGS earthquake catalog, spanning from May 12, 1906, to August 24, 2022, within a 500km radius of Dhaka City, was analyzed to assess earthquake hazard and probability. It revealed that the country is located in an area with a high likelihood of earthquakes, and any moderate to major tremor might trigger an enormous human catastrophe. While 75% of the earthquakes were classified as the "light" category (4-4.9 Richter Scale), 64% occurred at shallow depths, and only 5% occurred within 200 kilometers of Dhaka. Since the 1990s, the earthquake frequency has increased significantly with an incidence rate of 1.556. The findings categorized the research area as having a relatively moderate risk of earthquake hazard, with depth, frequency, magnitude, and distance scores falling into various risk categories. Probability distributions of earthquake magnitudes were estimated using the graphical analysis and goodness-of-fit criteria. Cumulative probability distributions were also determined to predict earthquake occurrences of specific magnitudes in the coming years based on recurrence time. The study indicated a strong probability of major earthquakes in the future, which poses a severe threat to the country. Assessing the susceptibility of an area to earthquakes based on factors like geology, topography, population density, building quality, and coping mechanisms is crucial, and this earthquake catalog can support disaster preparedness, specific precautions in planning, and the development of a resilient nation.
Surgical management of radiculopathy following acute singe-level osteoporotic vertebral fracture of lower lumbar spine in geriatric patient: a retrospective study
Authors: Zhang Yao , Lu Yuzheng , Lin Wancheng , Yao Mingtao , Song Jipeng , Ding Lixiang 
Published: August 2023

Abstract

Background Radiculopathy of lower limb after acute osteoporotic vertebral fracture (OVF) in lower lumbar spine (LLS) is uncommon in geriatric patient. Surgical intervention is indicated in patient who is irresponsive to conservative treatment. The optimum operative strategy is controversial considering the poor general condition of this population. Herein we provided an algorithm for surgically managing this clinical scenario, hoping to provide reference for surgical decision. Methods We retrospectively studied the patients who suffered new-onset radiculopathy of lower limb after acute single-level OVF in LLS underwent surgical intervention in our department. The demographics, bone mineral density (BMD), AO classification of vertebral fracture, the preexisting degenerative changing (foraminal stenosis, lumbar disc herniation, etc.), and the fashion of surgical intervention were collected. The clinical outcomes, including pre- and postoperative Visual Analog Scale (VAS) scores for back and leg pain, Oswestry Disability Index (ODI), and MacNab criteria of response to surgery, were evaluated. Result From Sep 2019 to Dec 2021, twenty two patients with mean age and T-score of 68.59 ± 9.74 years and 2.86 ± 1.03, respectively, were analyzed. The most involved vertebra was L5 (54.5%), followed by L4 (27.3%) and L3 (18.2%). Fifteen patients (45.4)% were diagnosed with A1 type of AO classification, in which 11 patients (80.0%) were characterized by collapse of inferior end-plate. Three patients (13.6%) suffered A2 type fracture, while four patients (18.2%) suffered A3 type fracture. Preexisting degenerative changing was observed in 54.5% of all patients. Sixteen patients (72.7%) were treated by percutaneous kyphoplasty (PKP). Three patients underwent posterior instrumentation and fusion, two patients underwent secondary endoscopic foraminoplasty, one patient underwent secondary radiofrenquency ablation. The mean follow-up period was 17.42 ± 9.62 months. Mean VAS for leg/back pain and ODI were significantly decreased after surgery (P < 0.05). Based on the Macnab criteria, the total satisfaction rate was 90.9% at the last follow-up. Conclusion Patient with OVF which involved inferior end-plate is predisposed to suffer lower-limb radiculopathy. PKP alone or with other minimally-invasive surgery is safe and effective for treating stable fracture. Aggressive surgical intervention should be considered in patient with unstable fracture or severe foraminal encroachment.