bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualization and analysis of key performance indicators for agricultural cold supply chain in Indian context using fuzzy DEMATEL approach
Authors: Kumar Neeraj , Tyagi Mohit , Sachdeva Anish 
Published: July 2023

PurposeThis study aims to discover the key performance indicators (KPIs) of the agricultural cold supply chain (ACSC) and analyze their consequences on the performance of ACSC within the bounds of Indian topography.Design/methodology/approachThe KPIs have been explored based on the literature review both in global and Indian context and domain expert's opinions. The interdependency characteristics and cause–effect relationship among the KPIs have been analyzed using a fuzzy decision-making trial and evaluation laboratory (f-DEMATEL) approach.FindingsThe findings extracted from the empirical assessment of the problem find strong compliance with the notions of theoretical model assessment. The results highlight that the cost of product waste and operating and performance costs are the two most important performance indicators of an Indian ACSC. Furthermore, governmental policies and regulations and the effectiveness of cold chain (CC) equipment also have a high degree of influencing characteristics on ACSC performance.Research limitations/implicationsTo connect the study with practicalities, the assessment of the KPIs is allied with real-time practices by clustering the beliefs of Indian professionals. Therefore, the decision-making behavior of the experts might be influenced by geographical constraints. However, the key findings provide advantages to the ACSC players, a bright hope for future food security and a significant profit for farmers.Originality/valueThe presented paper encompasses various aspects of the ACSC, including theoretical and empirical perspectives exercised to contemplate the system dynamics, which inculcates the essence of the associated practicalities. Thus, this study has various practical contributions relevant to managerial and societal perspectives.
Selection determinants and value creation in private equity investment: a systematic literature review
Authors: Rawal Vrinda , Kapil Sheeba 
Published: July 2023

Purpose
This paper aims to review, systematize and map the extant literature on private equity (PE) and study the underlying research agenda for investment selection and value creation in portfolio firms of PE investors. The PE investment process entails the preinvestment stage, where PE investors screen the target firms, and the postinvestment stage, where PE investors monitor the funded firms. With the motive to understand both stages, this review consolidates the findings of existing literature.

Design/methodology/approach
This research adopts a systematic literature review approach to study the underlying themes in PE investment literature. To adequately profile the key research areas, the authors have adopted citation classics in addition to keyword search and drawn the most significant papers in this field of research based on citation metrics.

Findings
The review presents a heterogeneous set of themes by encapsulating the relevant PE literature and identifies significant and emergent themes within the broad research area of investment and performance. The foundational themes found are selection determinants for PE investments, value creation in PE investments and selection vs value-adding effect of PE investors. While the emergent themes are the relative performance of PE investments; sources of value creation; skill, luck and social capital in PE; and resource dependency vis-à-vis PE. Each theme or subtheme chalks out the underlying research agendas for future researchers.

Originality/value
To build an understanding of the selection determinants and value creation, this review addresses the need to synthesize and align the PE literature concerning pre and post investment stages. PE is a fertile research area that is systematically captured in this review by identifying themes, subthemes and avenues for future research.
Does positive supervisory support impede knowledge hiding via psychological ownership and workplace thriving?
Authors: Usman Muhammad , Mehmood Qaiser , Ghani Usman , Ali Zulqurnain 
Published: July 2023

Purpose
This study aims to examine how positive supervisory support plays a role in attenuating employees’ knowledge-hiding behavior via the underlying mechanism of psychological ownership and workplace thriving. Integrating the social information processing perspective and conservation of resource theory, this study suggests that due to the mediating role of employee psychological ownership and workplace thriving, positive supervisor support may negatively affect knowledge-hiding behavior.

Design/methodology/approach
Hypotheses were tested with multiwave three-round survey data collected among 432 individuals in various Pakistani hotels.

Findings
This study found that supervisory support attenuated knowledge-hiding behavior by enhancing psychological ownership and workplace thriving serially. As expected, the supportive conduct of the supervisor positively influenced psychological ownership which, in turn, helped workplace thriving and eventually influenced employees’ knowledge hiding.

Originality/value
This study contributes to the extant body of knowledge on knowledge hiding by highlighting a significant antecedent that supervisory support may be instrumental in discouraging knowledge hiding. Furthermore, this study detailed an underlying serial mediating mechanism in the shape of psychological ownership and workplace thriving that connects supervisory support with reduced knowledge hiding.
Gene‐level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay
Authors: Jeon Taesung , Oh Uk Jeen , Min Jaeyoung , Kim Chungyeul 
Published: July 2023

AbstractBackgroundAmplification of the 3q region has been identified as a useful biomarker for the diagnosis and treatment of squamous cell carcinoma (SqCC). This region contains genes such as PIK3CA and YEATS2, which have been linked to the prognosis of SqCC.MethodsThe NanoString nCounter assay is a powerful tool for identifying genetic alterations that affect the progression and prognosis of SqCC. The NanoString nCounter assay was used to identify a subgroup of patients with gene level gain in the 3q region.ResultsGene level gain in the 3q region was more frequent in SqCC than in adenocarcinoma. We found that genes such as PIK3CA and YEATS2 in the 3q region were associated with the prognosis of SqCC. Therefore, identifying a subgroup of patients with gene level gain in the 3q region using the NanoString nCounter assay can aid in selecting appropriate treatment options and improving prognostic predictions for SqCC patients.ConclusionAmplification of the 3q region in SqCC of lung cancer is a useful biomarker for diagnosis and treatment. The NanoString nCounter assay is a powerful tool for identifying specific genetic alterations that affect the progression and prognosis of SqCC. Our study highlights the importance 3q amplification and its associated genes in lung cancer.
Integrated recovery system with bidding‐based satisfaction: An adaptive multi‐objective approach
Authors: Zhong Huifen , Lian Zhaotong , Zhou Tianwei , Niu Ben , Xue Bowen 
Published: July 2023

AbstractEfficient management of aircraft and crew recovery system is crucial for cost savings and improving the satisfaction, which are related to the airline's reputation. However, most existing work considers only one objective of minimizing costs or maximizing satisfaction. In this study, we propose a new integrated multi‐objective recovery system that takes both cost and satisfaction into account simultaneously. To better capture crew satisfaction in the event of airport closure, a bidding mechanism for early off‐duty task is designed. To overcome the experience‐dependent and labour‐consuming problems associated with current manual or mathematical recoveries, we develop an intelligent optimizer based on multi‐swarm and MOPSO frameworks, termed adaptive seeking and tracking multi‐objective particle swarm optimization algorithm (ASTMOPSO). Specifically, during the evolutionary process, the sub‐swarm size undergoes adaptive internal transfer while executing more efficient evolutionary strategies to approach the global Pareto front. Additionally, five ad‐hoc repair procedures are designed to ensure feasibility for our aircraft and crew recovery system. The ASTMOPSO is applied to real‐world instances from Shenzhen Airlines with different sizes. Experimental results demonstrate the statistical superiority of our method over other popular peer algorithms. And the infeasible solution repair procedures significantly improve the feasibility rate by at least 40%, particularly for large‐scale instances.
Surgical outcomes of robot‐assisted radical cystectomy in octogenarian or older patients: A Japanese nationwide study
Authors: Chen Wei , Yokoyama Minato , Waseda Yuma , Kobayashi Masaki , Fan Bo , Fukuda Shohei , Tanaka Hajime , Yoshida Soichiro , Ai Masumi , Fushimi Kiyohide , Fujii Yasuhisa 
Published: July 2023

ObjectiveTo evaluate the surgical outcomes of robot‐assisted radical cystectomy (RARC) in octogenarian or older patients based on a Japanese nationwide database.MethodsThe diagnosis procedure combination database was used to extract the data on radical cystectomy cases. Surgical outcomes of RARC in octogenarian or older patients (older group) were initially compared to those of patients younger than 80 years (younger group). Then, the surgical outcomes of RARC in the older group were compared to those of open radical cystectomy (ORC) and laparoscopic radical cystectomy (LRC) in the same age group.ResultsBetween 2018 and 2021, 478 RARC cases in the older group and 2257 RARC cases in the younger group were identified. In the older group, ileal conduit, neobladder, and other urinary diversions were carried out in 352 (73.6%), 22 (4.6%), and 104 (21.8%) patients, respectively. In the older group, when compared with the younger group, the complication rate (24.9%), blood transfusion rate (41.4%), and in‐hospital mortality (1.4%) were equivalent, while significantly shorter anesthesia time and longer length of stay were observed in the older group (521.0 ± 140.4 min vs. 595.1 ± 141.71 min, p < 0.01, and 32.9 ± 16.8 days vs. 30.6 ± 17.8 days, p = 0.01, respectively). In the comparison of the surgical outcomes of older patients receiving RARC to those receiving ORC (n = 746) and LRC (n = 375), the RARC group had the lowest complication rate and the shortest length of stay, while the shortest anesthesia time was noted in the ORC group.ConclusionThe feasibility of RARC for octogenarian or older patients was demonstrated by the nationwide database study.
Vacant niches help predict invasion risk by birds
Authors: González‐del‐Pliego Pamela , Mendoza Manuel , Santana Joana , Ribeiro Joana , Reino Luís , Araújo Miguel B. 
Published: July 2023

AbstractAimIf communities have a ceiling determining the number of species that can coexist, then the ability of alien species to establish at any given location should be related to the quantity of vacant niches available. We developed a new approach to estimate the extent to which niches are vacant and then explored the relationship between vacant niches and alien species.LocationGlobal with focal tests in Europe and North America.TaxonBirds.MethodsDrawing on a global classification of trophic structures for birds, we calculated a ‘vacant niche ratio’ metric to quantify the expected level of saturation (i.e. number of vacant niches) for each 1° × 1° grid cell globally, based on the difference between expected and observed numbers of bird species for all trophic guilds. Next, we used random forests to examine if the presence of plant‐invertivore (whose food source represents plants, seeds, fruits and invertebrates) and granivore alien bird species was associated with the vacant niche ratio across well‐sampled regions.ResultsIn Europe, we found a significant relationship between alien species and vacant niches, with greater numbers of alien species being found in communities that offered greater numbers of vacant niches overall, and across habitat types. In North America, we found no significant relationship between plant‐invertivores and vacant niches, while for granivores, we found that areas with fewer vacant niches had greater numbers of alien species, especially in forests. However, vacant niches alone correctly predict 69% of the presence of alien bird species when combining both regions and trophic guilds.Main ConclusionsMost regions of the world have unsaturated bird communities, with the level of saturation in communities varying within regions and trophic guilds. We found that although often‐neglected, vacant niches are likely to be, at least partially, related with the successful establishment of alien bird species.
Irreversible repolarization of tumour‐associated macrophages by low‐Pi stress inhibits the progression of hepatocellular carcinoma
Authors: Lv Yang‐feng , Liao Zi‐qiang , Bi Qiu‐chen , Xie Chuan‐sheng , Wei Xiao‐yong , Yun Yi , He Yuan‐qiao , Tang Qun 
Published: July 2023

AbstractNumerous studies have shown the positive correlation between high levels of Pi and tumour progression. A critical goal of macrophage‐based cancer therapeutics is to reduce anti‐inflammatory macrophages (M2) and increase proinflammatory antitumour macrophages (M1). This study aimed to investigate the relationship between macrophage polarization and low‐Pi stress. First, the spatial populations of M2 and M1 macrophages in 22 HCC patient specimens were quantified and correlated with the local Pi concentration. The levels of M2 and M1 macrophage markers expressed in the peritumour area were higher than the intratumour levels, and the expression of M2 markers was positively correlated with Pi concentration. Next, monocytes differentiated from THP‐1 cells were polarized against different Pi concentrations to investigate the activation or silencing of the expression of p65, IκB‐α and STAT3 as well as their phosphorylation. Results showed that low‐Pi stress irreversibly repolarizes tumour‐associated macrophages (TAMs) towards the M1 phenotype by silencing stat6 and activating p65. Moreover, HepG‐2 and SMCC‐7721 cells were cultured in conditioned medium to investigate the innate anticancer immune effects on tumour progression. Both cancer cell lines showed reduced proliferation, migration and invasion, as epithelial–mesenchymal transition (EMT) was inactivated. In vivo therapeutic effect on the innate and adaptive immune processes was validated in a subcutaneous liver cancer model by the intratumoural injection of sevelamer. Tumour growth was significantly inhibited by the partial deprivation of intratumoural Pi as the tumour microenvironment under low‐Pi stress is more immunostimulatory. The anticancer immune response, activated by low‐Pi stress, suggests a new macrophage‐based immunotherapeutic modality.
Stratifying early‐onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry
Authors: Dennison Charlotte A. , Martin Joanna , Shakeshaft Amy , Riglin Lucy , Rice Frances , Lewis Cathryn M. , O'Donovan Michael C. , Thapar Anita 
Published: July 2023

BackgroundDepression and anxiety are the most common mental health problems in young people. Currently, clinicians are advised to wait before initiating treatment for young people with these disorders as many spontaneously remit. However, others develop recurrent disorder but this subgroup cannot be identified at the outset. We examined whether psychiatric polygenic scores (PGS) could help inform stratification efforts to predict those at higher risk of recurrence.MethodsProbable emotional disorder was examined in two UK population cohorts using the emotional symptoms subscale of the Strengths and Difficulties Questionnaire (SDQ). Those with emotional disorder at two or more time points between ages 5 and 25 years were classed as ‘recurrent emotional disorder’ (n = 1,643) and those with emotional disorder at one time point as having ‘single episode emotional disorder’ (n = 1,435, controls n = 8,715). We first examined the relationship between psychiatric PGS and emotional disorders in childhood and adolescence. Second, we tested whether psychiatric PGS added to predictor variables of known association with emotional disorder (neurodevelopmental comorbidity, special educational needs, family history of depression and socioeconomic status) when discriminating between single‐episode and recurrent emotional disorder. Analyses were conducted separately in individuals of European and South Asian ancestry.ResultsProbable emotional disorder was associated with higher PGS for major depressive disorder (MDD), anxiety, broad depression, ADHD and autism spectrum disorder (ASD) in those of European ancestry. Higher MDD and broad depression PGS were associated with emotional disorder in people of South Asian ancestry. Recurrent, compared to single‐episode, emotional disorder was associated with ASD and parental psychiatric history. PGS were not associated with episode recurrence, and PGS did not improve discrimination of recurrence when combined with clinical predictors.ConclusionsOur findings do not support the use of PGS as a tool to assess the likelihood of recurrence in young people experiencing their first episode of emotional disorder.
Preclinical evaluation of singlet oxygen‐cleavable prodrugs in combination with protoporphyrin IX‐photodynamic therapy in an orthotopic rat model of non‐muscle‐invasive bladder cancer
Authors: Rahman Kazi Md Mahabubur , Foster Barbara A. , You Youngjae 
Published: July 2023

AbstractPhotodynamic therapy (PDT) initially employed red light, which caused some patients to experience permanent bladder contractions. PDT using the FDA‐approved drug hexaminolevulinate (HAL), which produces protoporphyrin IX (PpIX) in the tumor, showed some promise but has low efficacy in treating non‐muscle‐invasive bladder cancer (NMIBC). We developed singlet oxygen‐activatable prodrugs of two anticancer drugs, paclitaxel and mitomycin C, to enhance the antitumor effect of PpIX‐PDT without producing systemic side effects, by promoting only local release of the active chemotherapeutic agent. Orthotopic NMIBC model was used to compare the efficacy of prodrugs only, PpIX‐PDT, and prodrugs + PpIX‐PDT. 532 nm laser with a total power of 50 mW for 20 min (60 J, single treatment) was used with HAL and prodrugs. Histology and microscopic methods with image analysis were used to evaluate the tumor staging, antitumor efficacy, and local toxicity. Prodrug + PpIX‐PDT produced superior antitumor efficacy than PpIX‐PDT alone with statistical significance. Both PpIX‐PDT alone and combination therapy resulted in mild damage to the bladder epithelium in the normal bladder area with no apparent damage to the muscle layer. Overall, SO‐cleavable prodrugs improved the antitumor efficacy of PpIX‐PDT without causing severe and permanent damage to the bladder muscle layer.
Understanding sexual citizenship for Asian MSM in Aotearoa
Authors: Wong Spar , Chubb Laura Ann 
Published: July 2023

Introduction: As members of a profession that promotes social justice and human rights, social workers are well positioned to engage in sexual health practices, such as providing human immunodeficiency virus (HIV) services, a significant aspect in the development of sexual citizenship—or supporting the rights and responsibilities of people in their sexual lives. Comprising part of the second largest ethnic minority group, Asian men who have sex with men (MSM) are the most HIV-affected ethnic minority group in Aotearoa New Zealand. However, social work practices with this cohort are non-specific. This article presents the concept of sexual citizenship as a lens through which to better understand the sexual health needs of Asian MSM in Aotearoa and how social workers or other health professionals might be supportive.
Approach: A narrative literature review of eight articles concerning Asian MSM’s sexual health in Aotearoa was undertaken. Three themes were identified from this review: 1) sexual stigma, discrimination and prejudice; 2) sexual health and layered identities, and 3) knowledge of safer sex practises.
Conclusions: As the fastest growing ethnic minority group in Aotearoa, more actions and resources are required to meet Asian, particularly Asian MSM’s, sexual health needs. The social work profession can play a critical role by advocating for sexual citizenship, providing supportive sexual health resources, and addressing sexual stigma and health disparities among Asian MSM.
Molecular Ensembles of Microbiotic Metabolites in Carcinogenesis
Authors: Shatova Olga P. , Zabolotneva Anastasiya A. , Shestopalov Aleksandr V. 
Published: July 2023

Abstract
The mechanisms of carcinogenesis are extremely complex and involve multiple components that contribute to the malignant cell transformation, tumor growth, and metastasis. In recent decades, there has been a growing interest in the role of symbiotic human microbiota in the regulation of metabolism and functioning of host immune system. The symbiosis between a macroorganism and its microbiota has given rise to the concept of a holoorganism. Interactions between the components of a holoorganism have formed in the process of coevolution, resulting in the acquisition by microbiotic metabolites of a special role of signaling molecules and main regulators of molecular interactions in the holoorganism. As elements of signaling pathways in the host organism, bacterial metabolites have become essential participants in various physiological and pathological processes, including tumor growth. At the same time, signaling metabolites often exhibit multiple effects and impact both the functions of the host cells and metabolic activity and composition of the microbiome. This review discusses the role of microbiotic metabolites in the induction and prevention of malignant transformation of cells in the host organism and their impact on the efficacy of anticancer therapy, with special emphasis on the involvement of some components of the microbial metabolite molecular ensemble in the initiation and progression of tumor growth.
Evaluation of the Antitumor Potential of Soloxolone Tryptamide against Glioblastoma Multiforme Using in silico, in vitro, and in vivo Approaches
Authors: Markov Andrey V. , Odarenko Kirill V. , Sen’kova Aleksandra V. , Ilyina Anna A. , Zenkova Marina A. 
Published: July 2023

Abstract
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by uncontrollable diffusive growth, resistance to chemo- and radiotherapy, and a high recurrence rate leading to a low survival rate of patients with GBM. Due to a large number of signaling pathways regulating GBM pathogenesis, one of the promising directions is development of novel anti-glioblastoma compounds based on natural metabolites capable of affecting multiple targets. Here, we investigated the antitumor potential of the semisynthetic triterpenoid soloxolone tryptamide (STA) against human glioblastoma U87 cells. STA efficiently blocked the growth of U87 cells in 2D and 3D cultures, enhanced adhesiveness of tumor cells, and displayed synergistic cytotoxicity with temozolomide. In silico analysis suggested that the anti-glioblastoma activity of STA can be explained by its direct interaction with EGFR, ERBB2, and AKT1 which play an important role in the regulation of GBM malignancy. Along with direct effect on U87 cells, STA normalized tumor microenvironment in murine heterotopic U87 xenograft model by suppressing the development of immature blood vessels and elastin production in the tumor tissue. Taken together, our results clearly demonstrate that STA can be a novel promising antitumor candidate for GMB treatment.