bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke
Authors: Jha Vishwanath , Xiong Bei , Kumari Tripti , Brown Gavriel , Wang Jinzhi , Kim Kyungho , Lee Jingu , Asquith Nathan , Gallagher John , Asherman Lillian , Lambert Taylor , Bai Yanyan , Du Xiaoping , Min Jeong-Ki , Sah Rajan , Javaheri Ali , Razani Babak , Lee Jin-Moo , Italiano Joseph E. , Cho Jaehyung 
Published: May 2023

Background:

Platelet adhesion and aggregation play a crucial role in arterial thrombosis and ischemic stroke. Here, we identify platelet ERO1α (endoplasmic reticulum oxidoreductase 1α) as a novel regulator of Ca
2+
signaling and a potential pharmacological target for treating thrombotic diseases.

Methods:
Intravital microscopy, animal disease models, and a wide range of cell biological studies were utilized to demonstrate the pathophysiological role of ERO1α in arteriolar and arterial thrombosis and to prove the importance of platelet ERO1α in platelet activation and aggregation. Mass spectrometry, electron microscopy, and biochemical studies were used to investigate the molecular mechanism. We used novel blocking antibodies and small-molecule inhibitors to study whether ERO1α can be targeted to attenuate thrombotic conditions.

Results:

Megakaryocyte-specific or global deletion of Ero1α in mice similarly reduced platelet thrombus formation in arteriolar and arterial thrombosis without affecting tail bleeding times and blood loss following vascular injury. We observed that platelet ERO1α localized exclusively in the dense tubular system and promoted Ca
2+
mobilization, platelet activation, and aggregation. Platelet ERO1α directly interacted with STIM1 (stromal interaction molecule 1) and SERCA2 (sarco/endoplasmic reticulum Ca
2+
-ATPase 2) and regulated their functions. Such interactions were impaired in mutant STIM1-Cys49/56Ser and mutant SERCA2-Cys875/887Ser. We found that ERO1α modified an allosteric Cys49-Cys56 disulfide bond in STIM1 and a Cys875-Cys887 disulfide bond in SERCA2, contributing to Ca
2+
store content and increasing cytosolic Ca
2+
levels during platelet activation. Inhibition of Ero1α with small-molecule inhibitors but not blocking antibodies attenuated arteriolar and arterial thrombosis and reduced infarct volume following focal brain ischemia in mice.

Conclusions:

Our results suggest that ERO1α acts as a thiol oxidase for Ca
2+
signaling molecules, STIM1 and SERCA2, and enhances cytosolic Ca
2+
levels, promoting platelet activation and aggregation. Our study provides evidence that ERO1α may be a potential target to reduce thrombotic events.
The ha-index: The average citation
h-index
Authors: Fassin Yves 
Published: May 2023

Abstract
The ranking and categorizations of academic articles of a data set have traditionally been based on the distribution of their total citations. This ranking formed the basis for the definition of the h-index. As an alternative methodology, the ranking of articles of a data set can be performed according to the distribution of the average citations of the articles. Applying this same principle to the h-index itself leads to an average h-index, the ha-index: the largest number of papers ha published by a researcher who has obtained at least ha citations per year on average. The new ha-index offers more consistency, increased selectivity, and fairer treatment of younger scholars compared to the classic h-index. With its normalized time aspect, the method leads to better acknowledgment of progress. The evolution of the h-indices over time shows how the ha-index reaches its full potential earlier and offers more stability over time. The average citation ha-index partly solves the problem of the temporality of the h-index. he ha-index can also be applied to academic journals. In particular, the application of the ha-index to journals leads to more stability as they reach their limit sooner. The ha-index offers a response to the inflation of h-index levels.
Negatively-Formatted Requests for Confirmation in Korean Conversation: Three Types of Verbal Negation as Interactional Resources
Authors: Kim Kyu-hyun 
Published: May 2023

Abstract
From a conversation-analytic perspective, this article analyzes three types of verbal negation in Korean, which shape requests for confirmation (RfCs) into distinctive interactional resources. The pre-verbal negation (an) RfC emerges in the context where the recipient is prompted to see the “fittedness” of its confirmable as referencing an “allusive” aspect of his/her situated domain, inferentially formulated by the questioner as a “negative event.” The post-verbal negation (ci anh) renders the RfC a vehicle for making mitigated assertions, seeking the recipient’s agreement in acquiescence to the questioner’s “problematizing” stance. The use of post-nominalization negation (nun-ke ani) RfC exhibits the questioner’s “conjecturing” stance, displaying norm-based deontic orientations treating the noted event at hand as deviant or counter-expectational. The target of the confirmable is formulated an “entity” assessable by the recipient as an externally-positioned co-member/evaluator. Cross-linguistic implications of the findings are discussed, in relation to English tag questions and negative interrogatives.
Systemic Therapy in Elderly Patients With Her2/Neu-Positive Breast Cancer: A SEER Database Study
Authors: Wilbers Ashley , Quinn Karson R. , Okut Hayrettin , Helmer Stephen D. , Tenofsky Patty L. 
Published: May 2023

Background The use of systemic therapy in elderly patients with Her2/neu-positive breast cancers has been questioned given the potential for cardiac side effects with several of the agents frequently used. This study aimed to evaluate trends in use of systemic therapy in patients 70 years and older. Methods The 2010-2016 SEER database was used to collect data on female patients with non-metastatic Her2/neu-positive breast cancer. Data was stratified to compare systemic therapy use in patients <70 vs ≥70. Results A total of 62,014 patients were included in the study. Of those, 79.0% (38,760) of patients <70 years old received systemic therapy while only 45.2% (5844) of patients ≥70 received systemic therapy ( P < .001). Of patients ≥70 with ER positive tumors, 42.1% received systemic therapy and those with ER negative tumors, 52.1% received systemic therapy. The mortality rate in patients ≥70 was 8.5% in those who received systemic therapy and 12.1% in those who did not ( P < .001). Conclusions There remains a significant difference in rates of systemic therapy administration in the elderly population with an associated increase in mortality due to their cancer. Continuing educational efforts could be of benefit.
Severe depressive symptoms in patients with hypertension: Are antihypertensive medications implicated?
Authors: Gammoh Omar Salem , Alqudah Abdelrahim , Abu shaikh Hanan , Al-Shudifat Abdel-Ellah 
Published: May 2023

Objective This study examined whether antihypertensive medications and other patient characteristics are associated with severe depressive symptoms in patients with hypertension. Methods Patients with a diagnosis of hypertension were recruited from the internal medicine outpatient clinics of a hospital in Amman, Jordan, into this cross-sectional study. Depression severity was assessed using the Patient Health Questionnaire-9 (PHQ-9); anxiety by the General Anxiety Disorder-7; sleep quality by the Insomnia Severity Index; and psychological stress by the Perceived Stress Scale. Multivariable binary logistic regression was used to examine the association between the different classes of antihypertensive medication and depressive symptoms. Results Of the 431 participants, 282 (65.4%) were men; 240 (55.7%) reported having type 2 diabetes; 359 (83.3%) had dyslipidemia; 142 (32.9%) were on beta-blockers; 197 (45.2%) were on ACE inhibitors or angiotensin receptor blockers; 203 (47.1%) were on metformin; and 133 (30.9%) were taking sulfonylurea. Severe depressive symptoms, indicated by scoring above the cut-off of 14 on the PHQ-9, were present in 165 (38.3%) patients. Severe depression was associated with younger age (<55 years) (OR = 3.15, 95% CI = 1.83-5.41, P < 0.001), unemployment (OR = 2.15, 95% CI = 1.15-4.00, P = 0.01), diabetes (OR = 1.81, 95% CI = 1.09-3.02, P = 0.02), severe anxiety (OR = 6.40, 95% CI = 3.64-11.28, P < 0.001), and severe insomnia (OR = 4.73, 95% CI = 2.85-7.82, P < 0.001). Conclusion Severe depressive symptoms were not associated with antihypertensive medications or other drugs used by hypertensive patients. Younger age, diabetes, anxiety, and insomnia were the primary correlates of depression.
Patients’ Perceptions of Physical Therapists Addressing Opioid Misuse
Authors: Magel John , Hartman Paul , Fritz Julie M. , Koch Nicholas N. , Dostal Hannah , Vollmer Nicholas , Ferguson Natalie L. , Tapken Jennifer , Cohee Kim , Cochran Gerald , Gordon Adam J. 
Published: May 2023

Introduction: In the US, rising numbers of patients who misuse illicit or prescribed opioids provides opportunities for physical therapists (PTs) to be engaged in their care. Prior to this engagement, it is necessary to understand the perceptions of patients who access physical therapy services about their PTs playing such a role. This project examined patients’ perceptions of PTs addressing opioid misuse. Methods: We surveyed patients, newly encountering outpatient physical therapy services in a large University-based healthcare setting, via anonymous, web-based survey. Within the survey, questions were rated on a Likert scale (1 = completely disagree to 7 = completely agree) and we evaluated responses of patients who were prescribed opioids versus those who were not. Results: Among 839 respondents, the highest mean score was 6.2 (SD = 1.5) for “It is OK for physical therapists to refer their patients with prescription opioid misuse to a specialist to address the opioid misuse.” The lowest mean score was 5.6 (SD = 1.9) for “It is OK for physical therapists to ask their patient why they are misusing prescription opioids.” Compared to those with no prescription opioid exposure while attending physical therapy, patients with prescription opioid exposure had lower agreement that it was OK for the physical therapist to refer their patients with opioid misuse to a specialist (β = −.33, 95% CI = −0.63 to −0.03). Conclusions: Patients attending outpatient physical therapy seem to support PTs addressing opioid misuse and there are differences in support based on whether the patients had exposure to opioids.
Frequency of Hepatic Metastatic Disease in Patients with Stage IV Breast Cancer Is Similar for Steatotic and Non-Steatotic Livers
Authors: Haq Adeel , Fraum Tyler J , Tao Yu , Dehdashti Farrokh , LeBlanc Maverick , Hoegger Mark J , Luo Jingqin , Weilbaecher Katherine , Peterson Lindsay L 
Published: May 2023

Background: Breast cancer is the most common non-cutaneous malignancy and the second leading cause of cancer mortality in the United States. Breast cancer is a heterogeneous disease; diagnosis at an early stage renders it potentially curable, whereas advanced metastatic disease carries a worse prognosis. Objectives: To investigate whether hepatic steatosis (HS) is associated with liver metastases in patients with newly diagnosed stage IV female breast cancer patients (either de novo metastatic breast cancer or recurrent metastatic breast cancer) using non-contrast computed tomography (CT) as a marker of HS. Design: Retrospective analysis. Methods: We retrospectively identified 168 patients with stage IV breast cancer with suitable imaging from a prospectively maintained oncologic database. Three radiologists manually defined hepatic regions of interest on non-contrast CT images, and attenuation data were extracted. HS was defined as a mean attenuation <48 Hounsfield units. The frequency of hepatic metastatic disease was calculated for patient with and without HS. Relationships between HS and various patient (age, body mass index, race) and tumor (hormone receptor status, HER2 status, tumor grade) characteristics were also analyzed. Results: There were 4 patients with liver metastasis in the HS group (41 patients) versus 20 patients with liver metastases in the non-HS group (127 patients). The difference in frequencies of liver metastases among patients with (9.8%) versus without (15.7%) hepatic steatosis (odds ratio = 1.72 [0.53-7.39]) was not statistically significant ( P = .45). Body mass index was significantly higher ( P = .01) among patients with hepatic steatosis (32.2 ± 7.3 vs 28.8 ± 7.1 kg/m2). Otherwise, there were no significant differences between patients with versus without HS with respect to regarding age, race, hormone receptor status, HER2 status, or tumor grade. Conclusion: The frequency of hepatic metastatic disease in patients with stage IV breast cancer is similar for steatotic and non-steatotic livers.
Effectiveness and Safety of Multicomponent Physical Training in Patients With Chronic Obstructive Pulmonary Disease: Protocol for a Randomized Clinical Trial
Authors: Mazzarin Camila Monteiro , Silveira Bruna Roberta , Lamezon Ana Cristina , Cavon Luna Bruna , Valderramas Silvia 
Published: May 2023

Background: Currently, most Pulmonary Rehabilitation (PR) programs work with conventional physical training, using resources that are not available in public health in Brazil. Multicomponent physical training is a strategy that uses few resources and can reach a larger portion of the population. Objective: To investigate the effectiveness and safety of multicomponent physical training on physical-functional performance in patients with COPD. Design: Protocol for a randomized clinical trial with 2 groups in parallel (1:1). Setting: University-based, outpatient, physiotherapy clinic. Participants: 64 patients aged ⩾50 years, clinical-functional diagnosis of COPD, GOLD II and III criteria will participate in the study. Intervention: Participants will be randomly allocated into 2 groups: Multicomponent Physical Training—MPT (n = 32): aerobic, strength, balance and flexibility exercises performed in a circuit training format, or Conventional Physical Training—CPT (n = 32): aerobic and strength training. The interventions will be carried out twice a week, for 8 weeks and supervised by the same physiotherapist. Measurements: The 3 primary outcomes are the 6-Minute Walk Test (6MWT), the 6-Minute Step Test (6MST) and VO2 consumption as measured during the 6MWT. Secondary outcomes will be exercise capacity, level of physical activity in daily life, peripheral muscle strength, functional status, dyspnea, fatigue and quality of life. Safety will be assessed by recording adverse effects. These outcomes will be evaluated before and after the intervention and the evaluator will be blind. Limitations: It will not be possible to perform the blinding of the physiotherapist who will supervise the interventions. Conclusions: This study is expected to demonstrate that MPT using simple resources is an effective and safe intervention for the improvement of the aforementioned outcomes and, in addition, to broaden the horizon of research in relation to new methods of physical rehabilitation for patients with COPD.
Knowledge of autism gained by learning from people through a local UK Autism Champion Network: A health and social care professional perspective
Authors: Kirby Louise , Payne Katy-Louise 
Published: May 2023

Few autistic adults perceive that health and social care professionals have good understanding of autism. The countywide Autism Champion Network evaluated here, is an equal partnership of both staff across sectors (Autism Champions) and individuals with lived experience. Autism Champions take knowledge gained back to their teams to support continuous development of services to meet autistic need. This evaluation aims to examine the professional Autism Champions’ perceptions of (1) the knowledge gained through their local network and (2) the enablers and potential challenges of disseminating and applying the acquired knowledge. Seven health and social sector professionals participated in semi-structured interviews with thematic analysis identifying the themes ‘Learning from People’, ‘Makes you think of things in a different light’ and ‘There’s so much going on . . . ’. Results indicated that knowledge of autism gained from networking outside their own team was used and valued more than the professional presentations. It included signposting, sharing resources, using contacts to answer questions, and informal learning from autistic people. These results have implications for developing learning for Tier 2 and above staff. In addition, they could inform the development of future Autism Champion Networks to expand professionals’ knowledge of autism to reduce health and social care inequalities. Lay abstract The Autism Act 10 Years On found few autistic adults thought health and social care professionals had a good understanding of autism. Autism training has been made law in the United Kingdom for health and social care staff to tackle health inequality. The county wide Autism Champion Network evaluated here is an equal partnership of interested staff across sectors (Autism Champions) and autistic experts by virtue of lived experience (Autism Advisory Panel). With knowledge flowing both ways, the Autism Champions take learning back to teams to support continuous development of services to meet autistic need. Seven health and social sector professionals from the Network participated in semi-structured interviews on sharing knowledge of autism gained with their teams. All participants provide care and support for autistic people, some working in specialist positions. Results showed that developing new relationships with people outside their own team to signpost to, answer questions and share resources, and informal learning from autistic people, was more valued and used in practice than information gained from presentations. These results have implications in developing learning for those who need above a basic knowledge of autism and may be useful for others considering setting up an Autism Champion Network.
Readability of Online Patient Education Materials for Congenital Hand Differences
Authors: Baldwin Alexander J. 
Published: May 2023

Background: The aim of the study is to assess the readability of online patient education materials (PEMs) for congenital hand differences. Methods: The top 10 online, English-language PEMs for 10 conditions (polydactyly, syndactyly, trigger finger/thumb, clinodactyly, camptodactyly, symbrachydactyly, thumb hypoplasia, radial dysplasia, reduction defect, and amniotic band syndrome) were compiled and categorized by source and country. Readability was assessed using 5 tools: Flesch Reading Ease Score (FRES), Flesch-Kincaid Grade Level (FKGL), Gunning Fog Index (GFI), Coleman-Liau Index (CLI), and Simple Measure of Gobbledygook Index (SMOG). To account for the potential effect of each condition’s name in the aforementioned formulas, the analysis was repeated after replacing the name with a monosyllabic word/s. Results: The mean readability scores of the 100 PEMs were FRES 56.3, where the target was ≥80, FKGL 8.8, GFI 11.5, CLI 10.9, and SMOG 8.6, and the median grade score was 9.8, where the target grade was ≤6.9. Following adjustment, all readability scores improved significantly ( P < .001). Postadjustment scores were FRES 63.8, FKGL 7.8, GFI 10.7, CLI 9.1, and SMOG 8.0, and the median grade score was 8.6. Only 1 webpage met the target level using all tools. Two-sample t test for country of publication (the United States and the United Kingdom) demonstrated that PEMs originating from the United Kingdom were easier to read using the preadjustment CLI ( P = .009) and median grade metrics ( P = .048). A 1-way analysis of variance revealed no influence of condition or source on readability. Conclusion: Most online PEMs for congenital hand differences are written above the recommended reading level of sixth grade, even when adjusted for the effect of the condition’s name.
Green space for public mental health: an ethnographic study of ecotherapy in Wales
Authors: Lord E 
Published: May 2023

Aims: In recent years, there has been a growing interest in the ways that human health intersects with exposure to nature. This article reports the findings of a research study investigating the experiences of people in South and West Wales who were engaged in a specific type of nature and health intervention: ecotherapy. Methods: Ethnographic methods were used to develop a qualitative account of the experiences of participants in four specific ecotherapy projects. Data collected during fieldwork included notes from participant observations, interviews with both individuals and small groups, and documents produced by the projects. Results: Findings were reported using two themes: ‘smooth and striated bureaucracy’ and ‘escape and getting away’. The first theme focused on how participants negotiated tasks and systems related to gatekeeping, registration, record keeping, rule compliance, and evaluation. It was argued that this was experienced differently along a spectrum between striated, in which it was disruptive to time and space, and smooth, in which it was much more discrete. The second theme reported on an axiomatic perception that natural spaces represented an escape or refuge; in terms of both reconnecting with something beneficial in nature, and also disconnecting from pathological aspects of everyday life. In bringing the two themes into dialogue, it could be seen that bureaucratic practices often undermined the therapeutic sense of escape; and that this was more acutely experienced by participants from marginalised social groups. Conclusions: This article concludes by reasserting that the role of nature in human health is contested and arguing for a greater emphasis on inequities in access to good quality green and blue space. Specific interventions like ecotherapy need funding models that avoid striated bureaucratic processes, and the stress associated with these. Inclusive models of ecotherapy practice could contribute to public health goals related to population engagement with healthy environments.