bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drivers of sustained brand engagement: cases of long-term customers of hedonic and utilitarian brands in Japan
Authors: Ishizuka Chikako , Aoki Kei 
Published: August 2023

AbstractBrand engagement among customers is a dynamic process that requires continuous fostering by companies, irrespective of their products or brand nature. Despite extensive research into the antecedents and impacts of engagement, the aspect of engagement preservation remains under-explored in academic literature, particularly with utilitarian brands that often face challenges in achieving an engaged state compared to their hedonic counterparts. Consequently, this study investigates long-term (spanning from several years to over a decade) engagement of customers with four globally proliferating luxury brands and notable utilitarian brands in Japan, aiming to elucidate the factors pertinent to engagement retention. Employing co-occurrence network analysis via betweenness centrality, we strive to pinpoint the critical contexts influencing these customers. Our findings suggest that the key drivers maintaining engagement consist of a prominent utilitarian component for hedonic brands, and the facilitation of the hedonistic self by utilitarian brands.
A corpus-based study of euphemising body parts in Arabic subtitles
Authors: Sahari Yousef 
Published: August 2023

AbstractDrawing on prior taboo classifications and euphemism strategies, this study investigates the euphemisms that result from subtitling private body part-related taboo words (PBPRTW). The study utilised quantitative (frequencies and percentages) and qualitative approaches based on subtitler’s linguistic choices and the reasons behind their selection. The sample comprises 75 Hollywood feature films and their Arabic correspondences based on six criteria. The study adopts Pinker’s (2007) and McEnery’s (2006) for taboo language classifications and Al-Adwan’s typology for euphemism strategies, which draws upon Williams (1975), Warren (1992), and Davies (2003). The PBPRTW were selected on the basis of their frequent occurrence in the corpus, appearing more than 150 times. They serve various functions, including descriptive, abusive, referential, and idiomatic. The findings indicated that only approximately 5% of obscene words are retained in Arabic subtitles, while 95% of the English subtitles in the corpus are toned down, euphemised, or omitted. The study identified seven euphemistic strategies employed in dealing with PBPRTW in Arabic subtitles: metaphorical transfer, preservation, implication, metonymy, semantic misrepresentation, and widening. These findings have some implications for subtitlers when translating PBPRTW.
Injection Spectra of Different Species of Cosmic Rays from AMS-02, ACE-CRIS and Voyager-1
Authors: Pan Xu , Yuan Qiang 
Published: August 2023

Abstract
Precise measurements of energy spectra of different cosmic ray (CR) species have been obtained in recent years, by particularly the AMS-02 experiment on the International Space Station. It has been shown that apparent differences exist in different groups of the primary CRs. However, it is not straightforward to conclude that the source spectra of different particle groups are different since they will experience different propagation processes (e.g., energy losses and fragmentations) either. In this work, we study the injection spectra of different nuclear species using the measurements from Voyager-1 outside the solar system, and ACR-CRIS and AMS-02 on the top of atmosphere, in a physical framework of CR transportation. Two types of injection spectra are assumed, the broken power-law (BPL) form and the non-parametric spline interpolation form. The non-parametric form fits the data better than the BPL form, implying that potential structures beyond the constrained spectral shape of BPL may exist. For different nuclei the injection spectra are overall similar in shape but do show some differences among each other. For the non-parametric spectral form, the helium injection spectrum is the softest at low energies and the hardest at high energies. For both spectral shapes, the low-energy injection spectrum of neon is the hardest among all these species, and the carbon and oxygen spectra have more prominent bumps in 1–10 GV in the

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presentation. Such differences suggest the existence of differences in the sources or acceleration processes of various nuclei of CRs.
An Initial Analysis of a Strongly Lensed QSO Candidate Identified by LAMOST
Authors: Chen Y. H. , Tang M. Y. , Shu H. , Tu H. 
Published: August 2023

Abstract
From 2011 to 2021, LAMOST has released a total of 76,167 quasar data. We try to search for gravitationally lensed QSOs by limiting coordinate differences and redshift differences of these QSOs. The name, brightness, spectrum, photometry and other information of each QSO will be visually checked carefully. Special attention should be paid to check whether there are groups of galaxies, gravitationally lensed arcs, Einstein crosses, or Einstein rings near the QSOs. Through careful selection, we select LAMOST J160603.01+290050.8 (A) and LAMOST J160602.81+290048.7 (B) as a candidate and perform an initial analysis. Components A and B are 3.″36 apart and they display blue during photometric observations. The redshift values of components A and B are 0.2% different, their Gaia_g values are 1.3% different, and their ugriz values are 1.0% or less different. For the spectra covering from 3690 to 9100 Å, the emission lines of C ii, Mg, H γ, O iii, and H β are present for both components A and B and the ratio of flux(B) to flux(A) from LAMOST is basically a constant, around 2.2. However, no galaxies have been found between components A and B. Inada et al. identified them as binary quasars. But we accidentally find a galaxy group near components A and B. If the center of dark matter in the galaxy group is at the center between components A and B, components A and B are probably gravitationally lensed QSOs. We estimate that the Einstein mass is 1.46 × 1011
M
⊙ and the total mass of the lens is 1.34 × 1013
M
⊙. The deflection angle is 1.″97 at positions A and B and the velocity dispersion is 261 km s−1. Theoretically, this candidate could be a pair of fold images of a strong lensing system by a galaxy group, and we will investigate the possibility when the redshifts of nearby galaxies are available.
Photometric and Spectroscopic Study of Two Low Mass Ratio Contact Binary Systems: CRTS J225828.7-121122 and CRTSJ030053.5+230139
Authors: Wadhwa Surjit S. , Petrović Jelena , Tothill Nick F. H. , De Horta Ain Y. , Filipović Miroslav D. , Djurašević Gojko 
Published: August 2023

Abstract
The study reports photometric and spectroscopic observations of two recently recognized contact binary systems. Both systems show total eclipses and analysis of the light curves indicates both have very low mass ratios of less than 0.3. We derive absolute parameters from color and distance based calibrations and show that, although both have low mass ratios, they are likely to be in a stable orbit and unlikely to merge. In other respects, both systems have characteristics similar to other contact binaries with the secondary larger and brighter than their main sequence counterparts and we also find that the secondary is considerably denser than the primary in both systems.
Classifying Core Collapse Supernova Remnants by Their Morphology as Shaped by the Last Exploding Jets
Authors: Soker Noam 
Published: August 2023

Abstract
Under the assumption that jets explode all core collapse supernovae (CCSNe), I classify 14 CCSN remnants (CCSNRs) into five groups according to their morphology as shaped by jets, and attribute the classes to the specific angular momentum of the pre-collapse core. Point-symmetry (one CCSNR): According to the jittering jets explosion mechanism (JJEM) when the pre-collapse core rotates very slowly, the newly born neutron star (NS) launches tens of jet-pairs in all directions. The last several jet-pairs might leave an imprint of several pairs of “ears,” i.e., a point-symmetric morphology. One pair of ears (eight CCSNRs): More rapidly rotating cores might force the last pair of jets to be long-lived and shape one pair of jet-inflated ears that dominates the morphology. S-shaped (one CCSNR): The accretion disk might precess, leading to an S-shaped morphology. Barrel-shaped (three CCSNRs): Even more rapidly rotating pre-collapse cores might result in a final energetic pair of jets that clear the region along the axis of the pre-collapse core rotation and form a barrel-shaped morphology. Elongated (one CCSNR): A very rapidly rotating pre-collapse core forces all jets to be along the same axis such that the jets are inefficient in expelling mass from the equatorial plane and the long-lasting accretion process turns the NS into a black hole. The two new results of this study are the classification of CCSNRs into five classes based on jet-shaped morphological features, and the attribution of the morphological classes mainly to the pre-collapse core rotation in the frame of the JJEM.
SAGDTI: self-attention and graph neural network with multiple information representations for the prediction of drug–target interactions
Authors: Li Xiaokun , Yang Qiang , Luo Gongning , Xu Long , Dong Weihe , Wang Wei , Dong Suyu , Wang Kuanquan , Xuan Ping , Gao Xin 
Published: August 2023

Abstract

Motivation
Accurate identification of target proteins that interact with drugs is a vital step in silico, which can significantly foster the development of drug repurposing and drug discovery. In recent years, numerous deep learning-based methods have been introduced to treat drug–target interaction (DTI) prediction as a classification task. The output of this task is binary identification suggesting the absence or presence of interactions. However, existing studies often (i) neglect the unique molecular attributes when embedding drugs and proteins, and (ii) determine the interaction of drug–target pairs without considering biological interaction information.

Results
In this study, we propose an end-to-end attention-derived method based on the self-attention mechanism and graph neural network, termed SAGDTI. The aim of this method is to overcome the aforementioned drawbacks in the identification of DTI. SAGDTI is the first method to sufficiently consider the unique molecular attribute representations for both drugs and targets in the input form of the SMILES sequences and three-dimensional structure graphs. In addition, our method aggregates the feature attributes of biological information between drugs and targets through multi-scale topologies and diverse connections. Experimental results illustrate that SAGDTI outperforms existing prediction models, which benefit from the unique molecular attributes embedded by atom-level attention and biological interaction information representation aggregated by node-level attention. Moreover, a case study on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shows that our model is a powerful tool for identifying DTIs in real life.

Availability and implementation
The data and codes underlying this article are available in Github at https://github.com/lixiaokun2020/SAGDTI.
RepairNatrix: a Snakemake workflow for processing DNA sequencing data for DNA storage
Authors: Schwarz Peter Michael , Welzel Marius , Heider Dominik , Freisleben Bernd 
Published: August 2023

Abstract

Motivation
There has been rapid progress in the development of error-correcting and constrained codes for DNA storage systems in recent years. However, improving the steps for processing raw sequencing data for DNA storage has a lot of untapped potential for further progress. In particular, constraints can be used as prior information to improve the processing of DNA sequencing data. Furthermore, a workflow tailored to DNA storage codes enables fair comparisons between different approaches while leading to reproducible results.

Results
We present RepairNatrix, a read-processing workflow for DNA storage. RepairNatrix supports preprocessing of raw sequencing data for DNA storage applications and can be used to flag and heuristically repair constraint-violating sequences to further increase the recoverability of encoded data in the presence of errors. Compared to a preprocessing strategy without repair functionality, RepairNatrix reduced the number of raw reads required for the successful, error-free decoding of the input files by a factor of 25–35 across different datasets.

Availability and implementation
RepairNatrix is available on Github: https://github.com/umr-ds/repairnatrix.
Pathway-specific polygenic scores for Alzheimer’s disease are associated with changes in brain structure in younger and older adults
Authors: Harrison Judith R , Foley Sonya F , Baker Emily , Bracher-Smith Matthew , Holmans Peter , Stergiakouli Evie , Linden David E J , Caseras Xavier , Jones Derek K , Escott-Price Valentina 
Published: August 2023

AbstractGenome-wide association studies have identified multiple Alzheimer’s disease risk loci with small effect sizes. Polygenic risk scores, which aggregate these variants, are associated with grey matter structural changes. However, genome-wide scores do not allow mechanistic interpretations. The present study explored associations between disease pathway-specific scores and grey matter structure in younger and older adults. Data from two separate population cohorts were used as follows: the Avon Longitudinal Study of Parents and Children, mean age 19.8, and UK Biobank, mean age 64.4 (combined n = 18 689). Alzheimer’s polygenic risk scores were computed using the largest genome-wide association study of clinically assessed Alzheimer’s to date. Relationships between subcortical volumes and cortical thickness, pathway-specific scores and genome-wide scores were examined. Increased pathway-specific scores were associated with reduced cortical thickness in both the younger and older cohorts. For example, the reverse cholesterol transport pathway score showed evidence of association with lower left middle temporal cortex thickness in the younger Avon participants (P = 0.034; beta = −0.013, CI −0.025, −0.001) and in the older UK Biobank participants (P = 0.019; beta = −0.003, CI −0.005, −4.56 × 10−4). Pathway scores were associated with smaller subcortical volumes, such as smaller hippocampal volume, in UK Biobank older adults. There was also evidence of positive association between subcortical volumes in Avon younger adults. For example, the tau protein-binding pathway score was negatively associated with left hippocampal volume in UK Biobank (P = 8.35 × 10−05; beta = −11.392, CI −17.066, −5.718) and positively associated with hippocampal volume in the Avon study (P = 0.040; beta = 51.952, CI 2.445, 101.460). The immune response score had a distinct pattern of association, being only associated with reduced thickness in the right posterior cingulate in older and younger adults (P = 0.011; beta = −0.003, CI −0.005, −0.001 in UK Biobank; P = 0.034; beta = −0.016, CI −0.031, −0.001 in the Avon study). The immune response score was associated with smaller subcortical volumes in the older adults, but not younger adults. The disease pathway scores showed greater evidence of association with imaging phenotypes than the genome-wide score. This suggests that pathway-specific polygenic methods may allow progress towards a mechanistic understanding of structural changes linked to polygenic risk in pre-clinical Alzheimer’s disease. Pathway-specific profiling could further define pathophysiology in individuals, moving towards precision medicine in Alzheimer’s disease.
The Urgent Need to Implement Point-of-Care RNA Testing for Hepatitis C Virus to Support Elimination
Authors: Kapadia Shashi N , Jordan Ashly E , Eckhardt Benjamin J , Perlman David C 
Published: August 2023

Abstract
Hepatitis C virus (HCV) elimination is an important global public health goal. However, the United States is not on track to meet the World Health Organization's 2030 targets for HCV elimination. Recently, the White House proposed an HCV elimination plan that includes point-of-care (POC) HCV RNA testing, which is currently in use in many countries but is not approved in the United States. POC HCV RNA testing is crucial for implementing community-based testing and for enabling test-and-treat programs, assessing cure, and monitoring for reinfection. Here, we review the status of POC HCV RNA testing in the United States, discuss factors that are needed for successful implementation, and issue specific public health and policy recommendations that would allow for the use of POC HCV RNA testing to support HCV elimination.
Higher Serologic Responses of Early Syphilis to Single-dose Benzathine Penicillin G Plus Doxycycline Versus Single-dose Benzathine Penicillin G Alone Among People With HIV
Authors: Chen Kai-Hsiang , Sun Hsin-Yun , Chen Chung-Hsu , Chuang Yu-Chung , Huang Yu-Shan , Liu Wang-Da , Hsieh Szu-Min , Sheng Wang-Huei , Cheng Aristine , Wu Tzong-Yow , Lin Kuan-Yin , Hung Chien-Ching 
Published: August 2023

Abstract

Background
Single-dose benzathine penicillin G (BPG) is the preferred therapy for early syphilis, but poorer serologic responses have been observed among people with human immunodeficiency virus (PWH). No enhanced regimen has previously been shown to improve serologic outcomes of early syphilis.

Methods
We conducted a retrospective study to compare the treatment responses to single-dose BPG combined with 7-day doxycycline versus BPG alone in PWH who presented with early syphilis. Rapid plasma reagin (RPR) titers were determined every 3–6 months for all included PWH. Serologic response was defined as at least a 4-fold decline in RPR titers at month 12.

Results
During January 2018 to March 2022, 223 PWH with 307 episodes of early syphilis received single-dose BPG plus doxycycline and 347 PWH with 391 episodes received BPG alone. The median age was 36 years and baseline CD4 count was 600 cells/mm3. In the intention-to-treat with last-observation-carried-forward analysis, PWH receiving BPG plus doxycycline had a significantly higher serologic response rate at 12 months of treatment than those receiving BPG alone (79.5% vs 70.3%, respectively; P = .006). The factors associated with 12-month serologic response were RPR titer (per 1-log2 increase, adjusted odds ratio [AOR], 1.25; 95% confidence interval [CI], 1.15–1.35) and receipt of BPG plus doxycycline (AOR, 1.71; 95% CI, 1.20–2.46). In the subgroup analyses, BPG plus doxycycline was consistently associated with a better serologic response than BPG alone at month 12.

Conclusions
Among PWH with early syphilis, single-dose BPG plus doxycycline achieved higher serologic responses than BPG alone during a 12-month follow-up period.
In memoriam: Liv Hatle 1936–2023, pioneering echocardiologist
Authors: Fraser Alan G , Sutherland George R , Bijnens Bart 
Published: August 2023

AbstractProfessor Liv Hatle died in June 2023. In Trondheim, Norway, in the mid-1970s she was the first cardiologist to be given access to a PEDOF Doppler ultrasound system for clinical examinations, which she used to investigate cardiovascular haemodynamics non-invasively. She went on to establish methods for estimating valve gradients, pulmonary arterial pressure, and left ventricular diastolic function, that are still used today in millions of patients worldwide.
External validity of the PRECISE-DAPT score in patients undergoing PCI: a systematic review and meta-analysis
Authors: Munafò Andrea Raffaele , Montalto Claudio , Franzino Marco , Pistelli Lorenzo , Di Bella Gianluca , Ferlini Marco , Leonardi Sergio , D'Ascenzo Fabrizio , Gragnano Felice , Oreglia Jacopo A , Oliva Fabrizio , Ortega-Paz Luis , Calabrò Paolo , Angiolillo Dominick J , Valgimigli Marco , Micari Antonio , Costa Francesco 
Published: August 2023

Abstract

Aims
To summarize the totality of evidence validating the Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE-DAPT) score, ascertaining its aggregate discrimination and validation power in multiple population subsets.

Methods and results
We searched electronic databases from 2017 (PRECISE-DAPT proposal) up to March 2023 for studies that reported the occurrence of out-of-hospital bleedings according to the PRECISE-DAPT score in patients receiving DAPT following percutaneous coronary intervention (PCI). Pooled odds ratios (OR) with 95% confidence interval (CI) were used as summary statistics and were calculated using a random-effects model. Primary and secondary endpoints were the occurrence of any and major bleeding, respectively. A total of 21 studies and 67 283 patients were included; 24.7% of patients (N = 16 603) were at high bleeding risk (PRECISE-DAPT score ≥25), and when compared to those at low bleeding risk, they experienced a significantly higher rate of any out-of-hospital bleeding (OR: 2.71; 95% CI: 2.24–3.29; P-value &lt;0.001) and major bleedings (OR: 3.51; 95% CI: 2.71–4.55; P-value &lt;0.001). Pooling data on c-stat whenever available, the PRECISE-DAPT score showed a moderate discriminative power in predicting major bleeding events at 1 year (pooled c-stat: 0.71; 95% CI: 0.64–0.77).

Conclusion
This systematic review and meta-analysis confirms the external validity of the PRECISE-DAPT score in predicting out-of-hospital bleeding outcomes in patients on DAPT following PCI. The moderate discriminative ability highlights the need for future improved risk prediction tools in the field.
Cardiovascular outcomes in patients with coronary artery disease and elevated lipoprotein(a): implications for the OCEAN(a)-outcomes trial population
Authors: Shiyovich Arthur , Berman Adam N , Besser Stephanie A , Biery David W , Huck Daniel M , Weber Brittany , Cannon Christopher , Januzzi James L , Booth John N , Nasir Khurram , Di Carli Marcelo F , López J Antonio G , Kent Shia T , Bhatt Deepak L , Blankstein Ron 
Published: August 2023

Abstract

Aims
The ongoing Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction [OCEAN(a)]-Outcomes trial is evaluating whether Lp(a) lowering can reduce the incidence of cardiovascular events among patients with prior myocardial infarction (MI) or percutaneous coronary intervention (PCI) and elevated Lp(a) (≥200 nmol/L). The purpose of this study is to evaluate the association of elevated Lp(a) with cardiovascular outcomes in an observational cohort resembling the OCEAN(a)-Outcomes trial main enrolment criteria.

Methods and results
This study included patients aged 18–85 years with Lp(a) measured as part of their clinical care between 2000 and 2019. While patients were required to have a history of MI, or PCI, those with severe kidney dysfunction or a malignant neoplasm were excluded. Elevated Lp(a) was defined as ≥200 nmol/L consistent with the OCEAN(a)-Outcomes trial. The primary outcome was a composite of coronary heart disease death, MI, or coronary revascularization. Natural language processing algorithms, billing and ICD codes, and laboratory data were employed to identify outcomes and covariates. A total of 3142 patients met the eligibility criteria, the median age was 61 (IQR: 52–73) years, 28.6% were women, and 12.3% had elevated Lp(a). Over a median follow-up of 12.2 years (IQR: 6.2–14.3), the primary composite outcome occurred more frequently in patients with versus without elevated Lp(a) [46.0 vs. 38.0%, unadjHR = 1.30 (95% CI: 1.09–1.53), P = 0.003]. Following adjustment for measured confounders, elevated Lp(a) remained independently associated with the primary outcome [adjHR = 1.33 (95% CI: 1.12–1.58), P = 0.001].

Conclusion
In an observational cohort resembling the main OCEAN(a)-Outcomes Trial enrolment criteria, patients with an Lp(a) ≥200 nmol/L had a higher risk of cardiovascular outcomes.