bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Eco‐Friendly and Multifunctional Textile Integrating Radiative Heating and Cooling for Large‐Temperature‐Variation Personal Thermal Management
Authors: Zhang Jiankang , Dong Huilin , Yu Yian , Yin Shiqi , Cao Mengyao , Li Cuihuan , Shen Xiaoying , Li Junying , Xu Yanglei , Chen Sheng , Xu Feng 
Published: January 2025

AbstractRadiative heating or cooling textiles offer a sustainable means for personal thermal management (PTM). However, textiles that can realize efficient PTM under both large indoor and outdoor temperature variations are still lacking. Herein, guided by a heat transfer model, an eco‐ and user‐friendly bilayer textile (i‐textile) integrating radiative heating and cooling is developed. The i‐textile is composed of an MXene layer and a cellulose acetate (CA) layer with asymmetrical spectral characteristics. This textile provides heating when the MXene layer faces outward and cooling by wearing the textile inside out when the CA layer faces outward, thus enabling a decreased skin temperature variation range (7.3 and 6.8 °C lower than those when wearing cotton textiles) under large temperature variations indoors (12.6 °C) and outdoors (19.6 °C), respectively. Moreover, the i‐textile presents excellent wearability (breathability and washing resistance), recyclability, and biodegradability and can save≈30% of the building heating and cooling energy if widely deployed in China.
Tumor‐Resident Intracellular Bacteria Scavenger Activated In Situ Vaccines for Potent Cancer Photoimmunotherapy
Authors: Lv Bai , Zhao Yifan , Li Gang , Jiang Huimei , Zhang Min , Li Zequn , Cao Jie 
Published: January 2025

AbstractIn situ tumor vaccines, which utilize antigens generated during tumor treatment to stimulate a cancer patient's immune system, has become a potential field in cancer immunotherapy. However, due to the immunosuppressive tumor microenvironment (ITME), the generation of tumor antigens is always mild and not sufficient. Tumor‐resident intracellular bacteria have been identified as a complete tumor microenvironment component to contribute to creating ITME. Herein, a tumor‐resident intracellular bacteria scavenger is designed to induce enhanced antitumor photoimmunotherapy‐driven in situ vaccines for treating hypoxic tumors. This scavenger is developed by integrating photosensitizer CyI and antibiotics Doxycycline (Doxy) into thermal‐sensitive tumor‐derived exosomes fused liposomes (ECDL). In vitro and in vivo results showed that ECDL could homologous target to cancer cells and restrict the respiration of mitochondrial to reduce tumor hypoxia, thus providing continuous oxygen to eliminate both tumor cells and tumor‐resident intracellular bacteria, which could induce in situ vaccines for ablating the primary tumor and inhibiting the tumor metastasis and recurrence. Moreover, eliminating tumor‐resident intracellular bacteria neutralizes the ITME and triggers the production of bacterial‐related neoantigens, which could further strength the immunotherapy. This study provided versatile and effective in situ vaccines that are promising for local, abscopal, and metastatic tumor treatment.
Efficient and Scalable Direct Regeneration of Spent Layered Cathode Materials via Advanced Oxidation
Authors: Chen Wen , Li Junfeng , Ji Haocheng , Shi Ruyu , Wang Junxiong , Zhu Yanfei , Liu Jiachang , Zhang Ruixuan , Wu Zhiyun , Xiao Xiao , Wei Zhining , Zhou Guangmin 
Published: January 2025

AbstractAmong direct recycling methods for spent lithium‐ion batteries, solid‐state regeneration is the route with minimal bottlenecks for industrial application and is highly compatible with the current industrial cathode materials production processes. However, surface structure degradation and interfacial impurities of spent cathodes significantly hinder Li+ replenishment during restoration. Herein, we propose a unique advanced oxidation strategy that leverages the inherent catalytic activity of spent layered cathode materials to address these challenges. This strategy decomposes H2O2 to generate •OH and •O2− free radicals, facilitating oxidation reactions with the surface of the spent cathode. As a result, this approach effectively elevates the Ni valence state, modifies the surface microstructure, and eliminates fluorine‐containing interface impurities, thereby promoting the solid‐state regeneration process. The regenerated LiNi0.83Co0.12Mn0.05O2 cathodes demonstrate a specific capacity of 206 mAh g−1 at 0.1 C, comparable to commercially available cathodes. Meanwhile, this advanced oxidation strategy proves adaptable and scalable for treating industrial dismantled LiNi0.5Co0.2Mn0.3O2 black mass. A 3.1 Ah pouch cell assembled with the regenerated LiNi0.5Co0.2Mn0.3O2 exhibits impressive capacity retention of 74% after 500 cycles. Additionally, a techno‐economic analysis reveals that this strategy possesses low energy consumption, minimal environmental footprint, and high economic viability, suggesting its suitability for the battery recycling industry.
Bioinspired Electrostatic Capture‐and‐Release System for Precise Microdroplet Manipulation
Authors: Li Ning , Yang Peng , Bai Ziyi , Shen Tao , Liu Zhaoqi , Qin Siyao , Hu Jun , Yu Cunlong , Dong Zhichao , Chen Xiangyu 
Published: January 2025

AbstractThe application of physical fields is crucial for droplet generation and manipulation, underpinning technologies like printing, microfluidic biochips, drug delivery, and flexible sensors. Despite advancements, precise micro/nanoscale droplet generation and accurate microfluidic reactions remain challenging. Inspired by the liquid ejection mechanisms in microscopic organisms, an electrostatic manipulator for the precise capture, emission, and transport of microdroplets is proposed. This approach enables the controlled and periodic emission of nanoscale daughter droplets from microscale parent droplets, achieved through dielectric pinning on surfaces and electrostatic field‐driven forces. Results show precise nanoscale droplet release on inert polymer surfaces, enabling directional, contamination‐free liquid manipulation. Moreover, leveraging surface treatment techniques and robust electrostatic force‐driven transportation, a versatile strategy for droplet generation and manipulation, spanning from microfluidic devices to chemical reaction operations. The novel droplet manipulation phenomena and control strategies can advance the fields of electrostatic‐based microfluidics, materials fabrication, and beyond.
Temporal Lobe Epilepsy Perturbs the Brain‐Wide Excitation‐Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction
Authors: Xie Ke , Royer Jessica , Rodriguez‐Cruces Raul , Horwood Linda , Ngo Alexander , Arafat Thaera , Auer Hans , Sahlas Ella , Chen Judy , Zhou Yigu , Valk Sofie L. , Hong Seok‐Jun , Frauscher Birgit , Pana Raluca , Bernasconi Andrea , Bernasconi Neda , Concha Luis , Bernhardt Boris C. 
Published: January 2025

AbstractExcitation‐inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I imbalance at the macroscale, whole‐brain level, and its microcircuit‐level mechanisms and clinical significance remain incompletely understood. Here, the Hurst exponent, an index of the E/I ratio, is computed from resting‐state fMRI time series, and microcircuit parameters are simulated using biophysical models. A broad decrease in the Hurst exponent is observed in pharmaco‐resistant temporal lobe epilepsy (TLE), suggesting more excitable network dynamics. Connectome decoders point to temporolimbic and frontocentral cortices as plausible network epicenters of E/I imbalance. Furthermore, computational simulations reveal that enhancing cortical excitability in TLE reflects atypical increases in recurrent connection strength of local neuronal ensembles. Mixed cross‐sectional and longitudinal analyses show stronger E/I ratio elevation in patients with longer disease duration, more frequent electroclinical seizures as well as interictal epileptic spikes, and worse cognitive functioning. Hurst exponent‐informed classifiers discriminate patients from healthy controls with high accuracy (72.4% [57.5%–82.5%]). Replicated in an independent dataset, this work provides in vivo evidence of a macroscale shift in E/I balance in TLE patients and points to progressive functional imbalances that relate to cognitive decline.
Nanotherapy for Neural Retinal Regeneration
Authors: Yu Chuyao , Dong Li , Lv Yujia , Shi Xuhan , Zhang Ruiheng , Zhou Wenda , Wu Haotian , Li Heyan , Li Yitong , Li Zhou , Luo Dan , Wei Wen‐Bin 
Published: January 2025

AbstractRetinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies must overcome the challenges posed by the protective inner and outer blood‒retinal barriers. Nanotechnology applications in ophthalmology have shown great potential in addressing the issue of drug delivery to the eye. Moreover, nanotechnology‐based therapeutics can have profound clinical impacts on retinopathy, particularly retinal regeneration, thereby improving patient outcomes. Continuous advancements in nanotechnology are being applied to regenerate lost or damaged eye tissues and to treat vision loss and blindness caused by various retinal degenerative diseases. These approaches can be categorized into three main strategies: i) nanoparticles for delivering drugs, genes, and other essential substances; ii) nanoscaffolds for providing biocompatible support; and iii) nanocomposites for enhancing the functionality of primary or stem cells. The aim of this comprehensive review is to present the current understanding of nanotechnology‐based therapeutics for retinal regeneration, with a focus on the perspective functions of nanomaterials.
Meta‐Device for Field‐of‐View Tunability via Adaptive Optical Spatial Differentiation
Authors: Zhou Yin , Li Lin , Zhang Junhao , Cheng Jialuo , Liu Xiaoyuan , Gao Yunhui , Geng Zihan , Li Lei , Zhou Junxiao , Chen Mu Ku 
Published: January 2025

AbstractOptical edge detection is a crucial optical analog computing method in fundamental artificial intelligence, machine vision, and image recognition, owing to its advantages of parallel processing, high computing speed, and low energy consumption. Field‐of‐view‐tunable edge detection is particularly significant for detecting a broader range of objects, enhancing both practicality and flexibility. In this work, a novel approach—adaptive optical spatial differentiation is proposed for field‐of‐view‐tunable edge detection. This method improves the ability to acquire spatial information and facilitates edge detection over a wider angular range. The adaptive optical spatial differentiation meta‐device relies on two core components: the spatial differentiation dielectric metasurface and the adaptive liquid prism. The meta‐device is shown to function as a highly efficient (≈85%) isotropic spatial differentiator, operating across the entire visible spectrum (400 to 700 nm) within a wide‐angle object space, expanding up to 4.5 times the original field of view. The proposed scheme presents new opportunities for efficient, flexible, high‐capacity integrated data processing and imaging devices. And simultaneously provides a novel optical analog computing architecture for the next generation of wide field‐of‐view phase contrast microscopy.
The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus
Authors: Zhang Yao‐Yuan , Chen Song‐Tao , Chen Gang , Zhou Le , Zhou Guo‐Liang , Yu Xin‐Yuan , Yuan Long , Deng Wei‐Qian , Wang Zhen‐Bo , Li Jing , Tu Yi‐Fu , Zhang Da‐Wei , li Yuan , Sammad Abdul , Zhu Xiao , Yin Kai 
Published: January 2025

AbstractLarge‐scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence factors of Enterobacteriaceae/Escherichia‐Shigella in patients with T2DM‐related‐ASCVD, which correlates with their atherosclerotic stenosis is reported. Overexpression of T3SS via Citrobacter rodentium (CR) infection in Apoe‐/‐ T2DM mice exacerbated atherosclerotic lesion formation and increased gut permeability. Non‐targeted metabolomic and proteomic analysis of mouse serum showed that T3SS caused abnormal glycerophospholipid metabolism in mice. Proteomics, RNA sequencing, and functional analyses showed that T3SS induced ferroptosis in intestinal epithelial cells, partly due to increased expression of ferritin heavy chains (FTH1). This findings first demonstrated that T3SS increases ferroptosis in intestinal epithelial cells, via disrupting the intestinal barrier and upregulation of phosphatidylcholine, thereby exacerbating T2DM‐related ASCVD.
Ferroelectric Nematic Liquid Crystals Showing High Birefringence
Authors: Song Yaohao , Huang Xiang , Zhang Xinxin , Deng Minghui , Aya Satoshi , Huang Mingjun 
Published: January 2025

AbstractHigh birefringence nematic liquid crystals are particularly demanded for adaptive optics applications in the infrared spectrum because it enable a thinner cell gap for achieving fast response time and improved diffraction efficiency. The emerging ferroelectric nematic liquid crystals have attracted widespread interest in soft matter due to their unique combination of ferroelectricity and fluidity. However, the birefringence, which is one of the most important optical parameters in electro‐optic devices, is not large enough (<0.25) in most ferroelectric nematic materials. Here, a polar liquid crystal molecule library containing more than 60 molecules with a highly rigid and fluorinated nature is developed. The introduction of triple bonds constructs a long π‐electron conjugated mesogen skeleton, significantly improving the birefringence of polar liquid crystal phases. The birefringence and dispersion properties are systematically studied, demonstrating a strong dependence on chemical structures and the type of polar phases. Furthermore, through multi‐component mixing, polar liquid crystal mixtures with ultra‐wide temperature range and excellent stability at or near room temperature are obtained. They possess much higher birefringence than the existing ferroelectric liquid crystal materials. The unique combination of high birefringence and fluidic ferroelectricity is expected to promote the application of polar liquid crystals in electro‐optic technologies.
Tuning Hydrogen Binding on Ru Sites by Ni Alloying on MoO2 Enables Efficient Alkaline Hydrogen Evolution for Anion Exchange Membrane Water Electrolysis
Authors: Lee Goeun , Jun Sang Eon , Lim Jiheon , Kim Jaehyun , Lee Hyeryeon , Cheon Woo Seok , Ryoo Geun Woong , Cho Byeong‐Gwan , Lee Sooheyong , Kwon Min Sang , Park In‐Hyeok , Jang Ho Won , Park Sun Hwa , Kwon Ki Chang 
Published: January 2025

AbstractRuthenium (Ru)‐based electrocatalysts have shown promise for anion exchange membrane water electrolysis (AEMWE) due to their ability to facilitate water dissociation in the hydrogen evolution reaction (HER). However, their performance is limited by strong hydrogen binding, which hinders hydrogen desorption and water re‐adsorption. This study reports the development of RuNi nanoalloys supported on MoO2, which optimize the hydrogen binding strength at Ru sites through modulation by adjacent Ni atoms. Theoretical simulations reveal that substituting Ni atoms for adjacent Ru atoms reduces the high hydrogen adsorption Gibbs free energy on Ru while maintaining a low energy barrier for water dissociation. As a result, the RuNi/MoO₂ catalyst shows excellent HER performance with a low overpotential of 51 mV at a current density of 100 mA cm⁻2, outperforming commercial Pt/C. Furthermore, RuNi/MoO₂ demonstrates high turnover frequency (7.06 s−1), mass activity (13.4 A mg−1), and price activity (1030.77 A dollar−1). In an AEMWE cell, RuNi/MoO₂ as the cathode catalyst achieves a current density of 1 A cm−2 at 60 °C with just 1.7 V using 1 m KOH. This work highlights the potential of RuNi/MoO₂ for ultra‐high mass activity in efficient AEMWE applications.
Association Between Self‐Reported Lactose Intolerance, Additional Environmental Factors, and Bone Mineral Density in Young Adults
Authors: Falbová Darina , Švábová Petra , Beňuš Radoslav , Hozáková Alexandra , Sulis Simona , Vorobeľová Lenka 
Published: January 2025

ABSTRACTObjectivesThis study examines the relationship between self‐reported lactose intolerance (LI), environmental factors, and their effects on bone mineral density (BMD) in young adults from Slovakia.MethodsWe assessed 985 adults aged 18–30 years, with an average age of 21.61 ± 2.32 years, who were enrolled in this pilot cross‐sectional study during the period 2019–2023. Individual environmental factors (smoking status, alcohol consumption, physical activity, milk and milk product intake, and calcium intake) and self‐reported LI were assessed using a detailed questionnaire. BMD was analyzed using the QUS device (Sunlight MiniOmni), and total weight was measured with the InBody 770 bioimpedance analyzer.ResultsLinear regression analysis showed the independent influence of age, total weight, and the presence of LI on the speed of sound in meters per second (SOS; m/s) and Z‐score parameters in women (p < 0.05), whereas in men, age and smoking status were significant predictors of SOS (p < 0.05), and age and LI status significantly influenced the Z‐score (p < 0.05).ConclusionsIn the present study of young Slovak adults, the presence of self‐reported LI and smoking had a negative effect on BMD, resulting in lower BMD in the radius.
Synthesis of a Bis‐Boron/Sulfur Doped Ullazine and Direct Comparison with Its Boron/Nitrogen and Boron/Oxygen Analogues
Authors: Jiang Ruijun , Qin Tingting , Wang Yiping , Cui Huicong , Shi Yanping , Zhang Lei , Liu Xuguang 
Published: January 2025

AbstractUllazine, a typical polycyclic aromatic hydrocarbon with a 14 π‐electron nitrogen‐containing core, has garnered significant attention due to its excellent performance in optoelectronics applications. Integration of heteroatoms into the frameworks of polycyclic aromatic hydrocarbons is a well‐established strategy for modifying molecular characteristics and functionalities. In this study, heteroatom‐doped ullazine congener Bis‐BS‐U containing two boron‐sulfur bonds was synthesized. The structures and properties of Bis‐BS‐U were systematically compared to those of the previously reported bis‐boron/nitrogen doped ullazine (Bis‐BN‐U) and bis‐boron/oxygen doped ullazine (Bis‐BO‐U). Notably, the absorption and fluorescence spectra of Bis‐BS‐U exhibited a pronounced red shift relative to those of Bis‐BN‐U and Bis‐BO‐U. Theoretical calculations suggest that the boron/sulfur six‐member ring in Bis‐BS‐U exhibits very weak antiaromaticity. Moreover, the fluorescence intensity of Bis‐BS‐U showed an initial increase upon addition of Hg2+, followed by gradual decrease over time. This study expands the family of ullazine and provides valuable insights for the future development of heteroatom‐doped ullazines.
Predicting Alzheimer's disease subtypes and understanding their molecular characteristics in living patients with transcriptomic trajectory profiling
Authors: Huang Xiaoqing , Jannu Asha Jacob , Song Ziyan , Jury‐Garfe Nur , Lasagna‐Reeves Cristian A. ,   Alzheimer's Disease Neuroimaging Initiative, Johnson Travis S. , Huang Kun , Zhang Jie 
Published: January 2025

AbstractINTRODUCTIONDeciphering the diverse molecular mechanisms in living Alzheimer's disease (AD) patients is a big challenge but is pivotal for disease prognosis and precision medicine development.METHODSUtilizing an optimal transport approach, we conducted graph‐based mapping of transcriptomic profiles to transfer AD subtype labels from ROSMAP monocyte samples to ADNI and ANMerge peripheral blood mononuclear cells. Subsequently, differential expression followed by comparative pathway and diffusion pseudotime analysis were applied to each cohort to infer the progression trajectories. Survival analysis with real follow‐up time was used to obtain potential biomarkers for AD prognosis.RESULTSAD subtype labels were accurately transferred onto the blood samples of ADNI and ANMerge living patients. Pathways and associated genes in neutrophil degranulation‐like immune process, immune acute phase response, and IL‐6 signaling were significantly associated with AD progression.DISCUSSIONThe work enhanced our understanding of AD progression in different subtypes, offering insights into potential biomarkers and personalized interventions for improved patient care.Highlights
We applied an innovative optimal transport‐based approach to map transcriptomic data from different Alzheimer's disease (AD) cohort studies and transfer known AD subtype labels from ROSMAP monocyte samples to peripheral blood mononuclear cell (PBMC) samples within ADNI and ANMerge cohorts.
Through comprehensive trajectory and comparative analysis, we investigated the molecular mechanisms underlying different disease progression trajectories in AD.
We validated the accuracy of our AD subtype label transfer and identified prognostic genetic markers associated with disease progression, facilitating personalized treatment strategies.
By identifying and predicting distinctive AD subtypes and their associated pathways, our study contributes to a deeper understanding of AD heterogeneity.
A Stereocontrolled Synthesis of (+)‐Febrifugine via Azide and Azide‐Free Pathways
Authors: Uipanit Suwanan , Lamyong Kanyapat , Yakhampom Sujitra , Kongkathip Boonsong , Ngernmeesri Paiboon , Chuanopparat Nutthawat 
Published: January 2025

Abstract(+)‐Febrifugine, a natural antimalarial compound with a promising therapeutic profile, has become a hot target for synthetic chemists seeking to optimize its biological activity and expand its therapeutic applications. In this research, we present a stereocontrolled synthesis of (+)‐febrifugine using both azide and azide‐free approaches. Starting from the commercially available chiral pool precursor, d‐glucose, the synthesis was completed in 20 steps for both approaches. Key reactions included the Zn‐mediated Bernet‐Vasella reaction, Horner‐Wadsworth‐Emmons reaction, and cyclization for constructing the chiral substituted piperidine ring. Additionally, α‐bromoketone alkylation of quinazolinone was employed to assemble the (+)‐febrifugine core structure.
Unveiling the Magnetized Nature of X‐Ray Binaries: Cyclotron Line Insights Title
Authors: Tayem Mohammad , Abu‐Saleem Mohammad , Taani Ali 
Published: January 2025

ABSTRACTStudying the variations of measured cyclotron lines plays a crucial role in gaining insights into the physical processes of accretion in magnetized neutron stars. Our research focuses on the formation and distribution of magnetic fields in various high‐mass x‐ray binaries (HMXBs). Comparing these sources reveals valuable information about their origin and evolutionary history. It is worth noting that the presence of varying cyclotron lines can be attributed to the influence of accretion dynamics, which provides valuable information about the characteristics of the magnetic field. In addition, by visualizing data, we employ the Kernel Density Estimation method, to provide a robust framework for understanding the distribution of magnetic fields. We observed clear patterns of clustering in the energy range of (10–35) keV, which corresponds to magnetic fields of around G. This clustering indicates a shared magnetic field characteristics across these systems, suggesting a possible common origin or similar environmental and accretion condi tions. Finally, our research investigates the behavior of cyclotron lines in HMXBs, illuminating the accretion process and magnetic field properties to better understand their role as indicators of dynamical evolution.