bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cristianismo ortodoxo, relações Igreja-Estado e posicionamento pró-Rússia na Grécia e Romênia contemporâneas
Authors: Dias Pereira Luiz Felipe 
Published: June 2023

Esta pesquisa teve como objetivo analisar o posicionamento pró-Rússia na Grécia e naRomênia no aspecto religioso. A hipótese é de que o ambiente secular da União Européiafavorece um distanciamento desses países em relação à organização. Essa percepçãodiferente do papel da religião na vida pública contribui para uma percepção favorável daRússia como protetora dos cristãos ortodoxos no mundo. O referencial teórico foi compostoprincipalmente pelo construtivismo crítico e o debate referente ao papel da religião nasRelações Internacionais. Os métodos utilizados foram o process-tracing interpretativo deGuzzini e a análise de conteúdo.

Keywords: Religion. Secularism. International Relations. Orthodox Christianity. Russia.
Spatiotemporal estimation of fresh submarine groundwater discharge across the coastal shorelines of Oahu Island, Hawaii
Authors: Ghazal Kariem Abdulnabi , Leta Olkeba Tolessa , Dulai Henrietta 
Published: June 2023

Abstract
The integrated hydrological model is a powerful tool that is used to assess the temporal distribution of fresh groundwater discharge especially in coastal areas. The coastal regions of Hawaii are examples of crucial natural resources for the Hawaiian economy and general ecological health. To fully comprehend the intricate interactions between coastal hydrology processes and ecosystems, it is necessary to evaluate the fresh submarine groundwater discharge (FSGD) at the Heeia shoreline using an integrated hydrological modeling technique. Under steady-state settings, the results showed that the present daily average of FSGD is around 0.43 m3/days across 1 m of the shoreline. However, we showed that the FSGD values were considerably impacted by climate change, groundwater head of the coastal aquifer, recharge rate, and sea level rise, particularly by the end of the 21st century. The post-development FSGD fluxes were 1.5–3.5 times greater than the freshwater transported by the Heeia stream, demonstrating the considerable contribution of the FSGD to the coastal zones of Heeia. The results also showed an exponential association between the FSGD and the groundwater level for the coastal unconfined aquifer.
Spatial and seasonal variations in nutrient load and trophic status of Ganga and Yamuna rivers in Uttar Pradesh, India
Authors: Varma Kriti , Jha Pawan Kumar 
Published: June 2023

Abstract

Nutrient loading in aquatic systems from anthropogenic sources is a worldwide concern. The Ganga is the most important river in India, but pollution is currently severely threatening its biodiversity and long-term environmental viability. Water samples were taken from 36 locations along the length of the Ganga and Yamuna rivers in Uttar Pradesh and analysed for nutrient concentration to evaluate the nutrient load, eutrophication danger, and river trophic status. The average concentration of NO3-N, PO4-P, NH4-N, and SiO2-Si exceeded the values in unpolluted rivers, indicating the contribution of anthropogenic sources. The concentration of NO3-N and NH4-N showed significant spatial variation, and PO4-P showed significant seasonal variation in the study area. The DIN/DIP ratio in the study area exceeded 16:1, indicating a phosphate-limiting condition for phytoplankton development. The DSi/DIN value showed a declining trend in the downstream region of both rivers with average values &lt;1, indicating nitrate pollution leading to eutrophic conditions. The Indicator for Coastal Eutrophication Potential (ICEP) showed a positive value, indicating that the Ganga and Yamuna rivers in Uttar Pradesh were eutrophic due to nitrogen pollution. Trophic State Index (TSI) values indicated that super-eutrophic conditions existed in the Ganga River (65.62) and hypereutrophic conditions existed in the Yamuna River (75.55) in Uttar Pradesh.
Computational Protein Design - Where it goes?
Authors: Xu Binbin , Chen Yingjun , Xue Weiwei 
Published: June 2023

Abstract:
Proteins have been playing a critical role in the regulation of diverse biological
processes related to human life. With the increasing demand, functional proteins are
sparse in this immense sequence space. Therefore, protein design has become an important
task in various fields, including medicine, food, energy, materials, etc. Directed evolution
has recently led to significant achievements. Molecular modification of proteins
through directed evolution technology has significantly advanced the fields of enzyme engineering,
metabolic engineering, medicine, and beyond. However, it is impossible to
identify desirable sequences from a large number of synthetic sequences alone. As a result,
computational methods, including data-driven machine learning and physics-based
molecular modeling, have been introduced to protein engineering to produce more functional
proteins. This review focuses on recent advances in computational protein design,
highlighting the applicability of different approaches as well as their limitations.
A Comprehensive Exploration of Metabolism and Tumor Microenvironment
and Immunotherapy Response: Evidence From Large Populations in
Non-small Cell Lung Cancer
Authors: Chen Baorong , Hou Qinghua , Liu Linzhuang , Wu Liusheng , Wang Hanwen , Lai Xinyi , Liu Haozhen , Li Xiaoqiang , Liu Jixian 
Published: June 2023

Aims:
The study aimed to explore the effect of metabolism on lung cancer.

Background:
The tumor microenvironment is largely influenced by metabolism, tightly involved in
tumor progression.

Objective:
We try to investigate the effect of tumor metabolism terms on non-small cell lung cancer
(NSCLC) prognosis, drug and immunotherapy sensitivity, as well as its underlying mechanisms.

Methods:
All the data was obtained from The Cancer Genome Atlas and Gene Expression Omnibus
databases. R software was used to perform all statistical analyses and plots.

Results:
This study conducted 21 metabolism statuses in NSCLC to identify their underlying roles.
We found that alpha-linolenic acid metabolism, sphingolipid metabolism, glycerophospholipid metabolism,
fatty acid degradation, linoleic acid metabolism, primary bile acid biosynthesis, and fatty acid
metabolism were protective factors for NSCLC. Next, we constructed a prognosis model based on
primary bile acid biosynthesis, glycerophospholipid, and sphingolipid metabolism. Results in the present
study showed that our model could effectively predict patients' prognosis in both training and validation
cohorts. A clinical correlation revealed that patients at high-risk exhibited more progressive
clinical characteristics. Biological enrichment indicated that MYC targets, E2F targets, mTORC1 signaling,
G2/M checkpoint, and epithelial-mesenchymal transition were activated in the high-risk group.
Immune relation analysis showed that risk score positively correlated with Th2 cells, yet a negative
correlation with CD56 bright NK, Th17, mast and CD8+ T cells. Moreover, our model was related to
NSCLC patients' sensitivity to immunotherapy and chemotherapy. Ultimately, eight characteristic
genes were identified to distinguish the patients' risk group in the real application.

Conclusions:
The model we developed is a useful tool to predict NSCLC patients' prognosis and is
associated with the sensitivity of immunotherapy and chemotherapy. Meanwhile, our results can guide
the following metabolism-related studies in NSCLC.
The Tumor Microenvironment Affects Circulating Tumor Cells Metastasis
and the Efficacy of Immune Checkpoint Blockade in Non-small Cell Lung
Cancer
Authors: Zhang Xiuxiu , Qiu Sheng , Wang Cailian 
Published: June 2023

Abstract:
Lung cancer is one of the most lethal malignancies, with non-small cell lung cancer
(NSCLC) being the most common histologic subtype. Metastasis leads to poor prognosis for patients
with cancer. Tumor cells leave the tumor lesions, invade the surrounding stroma, and enter the bloodstream
as circulating tumor cells (CTCs). The development of CTCs is the beginning of metastasis.
The internal environment in which tumor cells grow and survive is called the tumor microenvironment
(TME). It includes tumor cells, fibroblasts, immune cells, and the extracellular matrix. The TME is
complex and dynamic. Moreover, the TME plays an important role in tumor development and metastasis
and significantly impacts therapeutic outcomes. Immune checkpoint blockade (ICB) aims to inhibit
the interaction of ligands with their corresponding receptors. ICB has the function of restoring
the anti-tumor effect of immune cells. This review examines how TME interacts with CTCs, allowing
CTCs to evade immunity and facilitating CTC metastasis. TME not only affects the progression of
tumor metastasis but also interacts with tumor cells, which may affect the efficacy of immunotherapy.
Hypertension-Mediated Organ Damage In Young Patients With First-Diagnosed And Never Treated Systolic Hypertension
Authors: Benas Dimitris , Triantafyllidi Helen , Birmpa Dionyssia , Fambri Anastasia , Schoinas Antonios , Thymis Ioannis , Kostelli Gavriela , Ikonomidis Ignatios 
Published: June 2023

Objective:
Early onset of untreated arterial hypertension is associated with an increased risk
for cardiovascular (CV) diseases. The evaluation of hypertension-mediated organ damage (HMOD)
helps estimating CV risk. We investigated the incidence of HMOD in young first, diagnosed and nevertreated
patients with systolic arterial hypertension (SH) to identify high CV-risk patients based on the
presence of HMOD.

Methods:
CV risk factors [smoking, obesity (body mass index, BMI)], hyperlipidemia and 5 HMODs
[arterial stiffness (pulse wave velocity, PWV), left ventricular diastolic dysfunction [(DD (E/Ea)], cardiac
hypertrophy (left ventricular mass index, LVMI), coronary artery microcirculation (CFR), and carotid
intima-media thickness (cIMT)] were evaluated before treatment initiation in 220 patients, aged ≤50
years [median (interquartile range, IQR) age=43(38-47)], with SH diagnosed by ambulatory blood pressure
monitoring (24-h ABPM).

Results:
Smoking (40%) and obesity [median (IQR) BMI=30(26-32) kg/m2](40%) were found in young
hypertensives. HMOD was found in 50% of hypertensives (10% had ≥2 HMOD). The most prevalent
HMODs were increased by cIMT (32%) and PWV (19%), LVH (9%), impaired CFR (6%) and DD
(1%). Only PWV (beta=0.27, p<0.001) and LVMI (beta=0.41, p<0.001) were associated with systolic
BP burden. In a subgroup analysis, patients with ≥2 HMOD were older with increased office BP and 24-
h ABPM, impaired lipid profile, and increased LVMI, PWV, CFR, and cIMT compared with the rest of
the hypertensives.

Conclusion:
The presence of ≥2 of the studied HMOD (PWV, LVMI, cIMT, E/Ea, CFR) in young hypertensives
characterizes a “high-risk population”. Arterial stiffness represents the predominant HMOD
and in the whole population and "high-risk population".
Advances in Chemistry of 2-(Piperazin-1-yl) Quinoline (Part IV)
Authors: El-Bana Ghada G. , Gouda Moustafa A. 
Published: June 2023

Abstract:
This review described the preparation of 2-(piperazin-1-yl) quinoline derivatives from 2-
haloquinolines and anilides, which underwent alkylation, arylation, acylation, and reductive amination
to form the 2-piprazinoquinolines. 2-(Piperazin-1-yl) quinoline used as building blocks for the
synthesis of polyfunctionalized heterocyclic compounds with pharmacological interest.
Berbamine Inhibits the Biological Activities of Prostate Cancer Cells by Modulating
the ROS/NF-κB Axis
Authors: Zhao Wanli , Jiang Yuqing , Jia Xiaopeng , Wang Xiuli , Guo Yuexian 
Published: June 2023

Background/Introduction:
Prostate cancer ranks as the second leading cause of cancer death. No effective
pharmacological agent is available for prostate cancer treatment. Berbamine is an alkaloid extracted from the Chinese
herb berberis, which exerts an effect on inhibiting cancer cell proliferation.

Objective:
This study aimed to explore the mechanism of berbamine in inhibiting prostate cancer.

Methods:
Prostate cancer cell lines PC-3 and DU145 cells were used to evaluate the effects of berbamine. Cell viability
was determined using cell-counting kit 8. The intracellular reactive oxygen species (ROS) levels were measured
using a ROS assay kit. Cell apoptosis rate was examined using flow cytometry. The protein levels associated with cell
proliferation, NF-κB pathway, and apoptosis were determined using western blot.

Results:
It was found that berbamine induced cell cycle arrest in the S phase and inhibited prostate cancer cell growth
and proliferation. Berbamine inhibited prostate cancer cells by inhibiting the activation of the NF-κB pathway in vitro.
Berbamine increased ROS as an upstream molecule that inhibited the NF-κB pathway.

Conclusion:
Our results demonstrated that berbamine can effectively reduce the proliferation of prostate cancer cells.
The ROS/NF-κB axis plays a crucial role in berbamine-mediated anti-prostate cancer cell proliferation.
Machupicchu. Investigaciones interdisciplinarias. Tomo I y II
Authors: González Madueño Consuelo 
Published: June 2023

Durante los últimos años se han venido desarrollando investigaciones en el Santuario Histórico-Parque Arqueológico Nacional de Machupicchu (SHM-PANM) de manera científica y constante, producto de ese trabajo se publica MACHUPICCHU, una compilación histórica - arqueológica de 39 artículos, que publica la Dirección Desconcentrada de Cultura de Cusco. La mayor parte de los textos son fruto de las investigaciones desarrolladas en el marco del Programa de Investigaciones Arqueológicas e Interdisciplinarias en el Santuario Histórico de Machupicchu, entre los años 2013 y 2017. Lo relevante de esta publicación es dar a conocer que el Santuario está compuesto por cerca de 60 monumentos, incluyendo andenes, centros ceremoniales, caminos, canales y otras muestras arquitectónicas. Dada la dificultad de reseñar todos los artículos, nos referiremos sólo a los que consideramos más representativos.
Perceived psychological reactions to second wave of pandemic COVID-19 Among Working Adult Indonesians: An online survey study
Authors: Ridwan Edi Sampurno , Indrayana Sofyan , Badrujamaludin Asep , Supriadi Dedi , Huda Nuh , Priyanto Priyanto , Saidah Qori Ila , Sutandi Aan 
Published: June 2023

<p><strong><em>Background</em></strong><em>: The Corona Virus Disease (Covid-19) pandemic caused serious health consequences including mental health issues. Thus, gaining insight into the emergence of mental health problems including fear, anxiety and stress in society during the second wave Covid-19 pandemic is imperative. </em></p><p><strong><em>Objectives</em></strong><em>: This study aimed to identify the psychological reactions of working Indonesians living in five metropolitan cities in Java Island and its association with personal characteristics during the second wave Covid-19 pandemic.</em></p><p><strong><em>Methods:</em></strong><em> This cross-sectional study included a total of 916 respondents from five metropolitan cities in the Island of Java that was voluntarily completing the anonymous online survey. The data were administered by using the Indonesian version of Perceived Stress Scale (PSS), Covid-19 Anxiety Scale (CAS), and Fear of Covid-19 Scale (FCS). Bivariate and multivariate analysis were performed using non-parametric methods due to non-normal distribution data. Significance for hypothesis testing was set with p-value 0.05 on 95% Confidence Interval. Data was analyzed using software STATA14 of StataCorp.</em></p><p><strong><em>Results:</em></strong><em> A total of 916 respondents were included, with the median of age being 28 years old. Perceived fear and anxiety to Covid-19 among working individuals was low (35.92% and 40.94%), yet they were on moderate and high-levels of stress (31.88% and 45.52%) respectively. After adjusted all predictors, age was a significant predictor to the level of fear (p&lt; 0.001), anxiety (p= 0.05), and stress (p&lt; 0.001). The first dose of vaccination significantly predicted a reduction in the fear of Covid-19 (p= 0.045).</em></p><p><strong><em>Conclusions</em></strong><em>: Increasing a year of age predicted the reduction of fear, anxiety, and perceived of stress to Covid-19. First dose vaccination significantly reduced the fear to Covid-19. </em></p>
Keterampilan literasi informasi pustakawan Universitas Negeri Malang dalam implementasi layanan berbasis inklusi sosial
Authors: Inawati Inawati , Setiawan Setiawan , Prasetyawan Adi 
Published: June 2023

Introduction. Inclusion-based libraries aim to improve information literacy, quality of life, and community welfare, as well as become a place for lifelong learning. The librarians need to have sufficient information literacy skills in implementing social inclusion-based services.
Data Collection Methods. Qualitative case study approach was used. The data was collected by interviews, observations, and documentation from librarians at the Malang State University Library.
Data Analysis. We analyzed our data by using data reduction, data presentation, and conclusion.
Results and Discussion. Information literacy skills of librarians were examined by several indicators such as identify, scope, plan, gather, evaluate, manage, and present. Those indicators have not been applied, particularly to the implementation of social inclusion-based services. Five indicators of information literacy skills can be applied properly including identification of needs information, determining the scope of information needs, planning information retrieval strategies, gathering information sources, as well as evaluating. In this study, skills in managing and presenting information have not been implemented properly.
Conclusion. The information literacy skills of librarians in social inclusion-based services have not been maximized due to absence of competency development, lack of librarians, and absence of collections and facilities that support all information needs based on the user.
Pengaruh motivasi terhadap perilaku knowledge sharing pegawai di Badan Pusat Statistik wilayah Sulawesi Tengah
Authors: Astuti Sri , Rachmawati Tine Silvana , Rusmana Agus 
Published: June 2023

Introduction. The insufficient level of understanding of statistical indicators is indicated by the low level of knowledge sharing culture among BPS employees in the Central Sulawesi region. In this case, BPS needs to encourage the employees to participate in knowledge sharing activities. Individual's willingness to share knowledge can be influenced by several factors, one of them is motivation. The main objective of this paper is to understand the influence of motivation to employee’s knowledge sharing activities in BPS. A conceptual model is designed based on the Theory of Reasoned Action (TRA).
Data Collection Methods. A quantitative-explanatory research method was applied including literature study, data collection, and data analysis.
Data Analysis. The study used the structural equation modeling-partial least squares (SEM-PLS) analysis method with a sample of 174 samples.
Results and Discussion. Motivation has a positive-significant effect (p-value <0.05) on attitudes (β = 0.713) and employee intentions (β = 0.218). This has implications for employee knowledge sharing behavior (β = 0.758). Motivation and attitude can predict the intention by 42.7%, meanwhile, the intention can predict behavior by 57.5%.
Conclusion. To predict the knowledge-sharing behavior of employees, a sufficient motivation is needed to develop positive attitudes and strong intentions in each employee.
Peran kepala sekolah dalam pengelolaan perpustakaan untuk mendukung pembelajaran di masa pandemi COVID-19
Authors: Setiawan Setiawan , Qalyubi Syihabuddin , Laugu Nurdin 
Published: June 2023

Introduction. This research is to examine perspectives of teachers, students and librarians toward leadership roles regarding information technology development in school libraries in supporting learning in the era of the COVID-19 pandemic.
Data Collection Methods. This study used a quantitative descriptive approach with 100 respondents. The sampling technique used the probability sampling with simple random sampling method.
Results and Discussion. The role of school leaders in developing library governance has not yet been significant so that libraries could not contribute effectively to the learning process. During the pandemic, the role of IT is needed by teachers and students, particularly for the library users to finish their assignment from home. Users also need to have the library updates regarding books. Many teachers and students do not understand how to use of information technology in the library including how to access or search information (online).
Conclusion. School leaders play an active role in improving the quality of the library as a source of learning to create benefits for the school community. The discussion on the abnormal situation leadership among school leaders.
Tamizaje de niveles tensionales en individuos no hipertensos entre 18-65 años en la comunidad de Pizarrete Abajo, municipio Nizao, provincia Peravia, República Dominicana, durante el período agosto-septiembre 2018
Authors: Barreto Nicole , Vásquez Emely , Rodríguez Alejandra , Lanurias Alan 
Published: June 2023

Introducción: la presión arterial elevada es el principal factor de riesgo de enfermedad global. En la República Dominicana el 31 % de la población padece de hipertensión arterial (HTA) y de este, un 60 % lleva tratamiento médico.
Objetivo: determinar los niveles tensionales en individuos no hipertensos entre 18-65 años en la comunidad de Pizarrete Abajo, durante el período agosto-septiembre 2018.
Metodología: estudio prospectivo, descriptivo y de corte longitudinal, en el que se analizaron 85 individuos que residen en la comunidad de Pizarrete Abajo, de los cuales 44 resultaron con niveles tensionales alterados.
Resultados: el 51.7 % de los encuestados presentó niveles de tensión arterial alterados, sin haber sido anteriormente diagnosticado con hipertensión arterial. Un 24 % de las personas mostró niveles alterados una semana después de la primera toma de presión arterial.
Conclusiones: en una muestra de 85 personas se encontraron niveles tensionales alterados en 44 individuos. Se procedió a una segunda toma de presión arterial una semana después de la primera y se observó que un 56.8 % correspondió a valores tensionales elevados, un 20.4 % a valores de HTA estadio 1 y un 18.1 % a valores de HTA estadio 2.