bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instrumental variable approach on analyzing risk factors associated with noncommunicable disease prevalence in Tanzania: A nonexperimental design
Authors: Kitole Felician A. , Sesabo Jennifer K. , Lihawa Robert M. 
Published: September 2023

AbstractBackground and AimsNoncommunicable diseases (NCDs) have emerged as a substantial burden in developing countries, representing the leading cause of mortality. Addressing this critical issue necessitates effective interventions and policy measures. Therefore, this study aims to investigate the risk factors associated with NCD prevalence in Tanzania.MethodsThis study employed a nonexperimental research design due to its ability to analyze secondary data without altering variables. The used data set of the study was sourced from National Panel Survey 2020/21 and Household Budget Survey 2017/18. The econometrics analysis applied in the study include two‐stage residual inclusion (2SRI) and control function approach due to their ability to suppress endogeneity and enhance the clarity of results.ResultsThe findings indicate a significant positive correlation between alcohol consumption (0.4110382, p = 0.02), cigarette smoking (0.3354297, p < 0.001), and NCDs, emphasizing the urgency of targeted interventions to mitigate these behaviors. Conversely, a negative correlation is observed between fruit and vegetable intake (−0.1063375, p < 0.001), physical exercises (−0.3744925, p < 0.001), and NCDs, underscoring the importance of promoting healthy dietary habits and frequent exercises.ConclusionThese results accentuate the immediate need for targeted interventions and policy measures to address these risk factors and effectively combat the escalating burden of NCDs in Tanzania and similar contexts. Moreover, the need for improved public awareness campaigns and the promotion of healthy life campaigns are vital in the fight to lower the prevalence of NCDs across communities.
Transdisciplinary science and the importance of Indigenous knowledge
Authors: Baker Virginia , Ataria James , Ankeny Rachel , Bray Heather 
Published: September 2023

Abstract
As we move ever closer to the brink of global environmental collapse, it is vital that we work collaboratively and collectively as global, national, and local communities to design multiscale change. Protecting future generations and reversing (or substantively slowing) the current trends require rapid sustainable progress at the required scale. It is more urgent than ever that we understand and more fully realize the power of transdisciplinary (Td) research to support sustainable practice. A defining factor of Td is the focus on collaboration and codesign and the extent that participation and attention to local context is integral to the knowledge building. Specifically, there is greater ability for community knowledge, values, and aspirations to influence and shape research inquiries to effect meaningful change in real-world decision-making and outcomes. Business-as-usual (BAU) approaches that perpetuate unequal knowledge sharing and dismiss other forms of knowledge beyond traditional science no longer suffice. Transdisciplinary approaches seek to achieve and support sustainable change, but the extent of transformation required to meet ecological protection and regenerative sustainability requires very different operating models for knowing and doing science than the limited traditions of positivist science. However, these powerful defaults and operating paradigms are more deeply ingrained than we might realize, and so challenges persist. This article illustrates how Td science differs from typical research paradigms, particularly in terms of the underlying epistemology; the focus on knowledge and/or power; attention to boundaries and scope; and the degree to which local knowledge, context, and community participation underpin the research process. Active conversations are required to better identify and overcome fundamental challenges for science and Td research approaches to support the necessary transformational change. Importantly, we suggest that Indigenous partnerships, knowledge, and values are vital in achieving the potential of Td research to provide transformational interventions to address complex social and environmental issues such as pollution. Integr Environ Assess Manag 2024;20:805–816. © 2023 SETAC
Insights on Covid‐19 with superimposed pulmonary histoplasmosis: The possible nexus
Authors: Almutawif Yahya A. , Al‐kuraishy Hayder M. , Al‐Gareeb Ali I. , Alexiou Athanasios , Papadakis Marios , Eid Hamza M. A. , Saad Hebatallah M. , Batiha Gaber El‐Saber 
Published: September 2023

AbstractA novel coronavirus (CoV) known as severe acute respiratory syndrome CoV type 2 is the causative agent for the development of CoV disease 2019 (Covid‐19). Covid‐19 may increase the risk of developing pulmonary histoplasmosis due to immune dysregulation. In addition, Covid‐19 may enhance the propagation of acute pulmonary histoplasmosis due to lung injury and inflammation, and using corticosteroids in severely affected Covid‐19 patients may reactivate latent pulmonary histoplasmosis. Likewise, activation of inflammatory signaling pathways during H. capsulatum infection may increase the severity of Covid‐19 and vice versa. Furthermore, lymphopenia in Covid‐19 may increase the risk for the progress of pulmonary histoplasmosis besides activation of inflammatory signaling pathways during H. capsulatum infection may increase the severity of Covid‐19 and vice versa. Therefore, this critical review aimed to find the potential link between Covid‐19 pneumonia and pulmonary histoplasmosis concerning the immunological response.
Diagnostic value of quantification of cell‐free DNA for suspected gallbladder cancer
Authors: Sakamoto Katsunori , Ogawa Kohei , Tamura Kei , Honjo Masahiko , Sogabe Kyosei , Ito Chihiro , Iwata Miku , Sakamoto Akimasa , Shine Mikiya , Nishi Yusuke , Uraoka Mio , Nagaoka Tomoyuki , Funamizu Naotake , Takada Yasutsugu 
Published: September 2023

AbstractBackground and AimAn accurate preoperative diagnosis as the basis for deciding the most appropriate surgical procedure is essential for patients with suspected gallbladder cancer (GBC). The aim of this study was to investigate the usefulness of cell‐free DNA (cfDNA) for the preoperative detection of ≥T2 invasion in patients with suspected GBC.MethodsTwenty‐four patients who underwent resection for suspected GBC were enrolled. The concentration of cfDNA obtained from blood samples preoperatively was measured and evaluated in two distributions. The first peak (less than 200 base pairs) of cfDNA distribution was defined as the shorter fragment cfDNA, considered to originate mainly from apoptosis; and the second peak (200 base pairs or more) was defined as the longer fragment cfDNA, originating mainly from necrosis.ResultsPathological analysis identified benign disease in 12 patients and GBC in 12 patients, of whom 6 patients had ≥pT2 GBC. Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19‐9 were significantly higher in the ≥pT2 GBC group than in the benign/<pT2 groups (2.1 [0.7–11.0] vs 4.5 [1.7–13.0], P = 0.033 and 14.0 [<2.0–401] vs 37.0 [26.0–141.0], P = 0.007, respectively). When limited to patients in the GBC group (n = 12), only cfDNA of longer fragments was significantly lower in the ≥pT2 group than the <pT2 groups (2.98 [1.88–4.61] vs 1.98 [1.42–2.42], P = 0.026) but cfDNA of shorter fragments showed no significant difference between above both comparisons.ConclusionCfDNA might have potential use as a diagnostic factor for patients with suspected GBC.
Cartilage deformation following a walking bout in individuals with anterior cruciate ligament reconstruction
Authors: Pamukoff Derek N. , Holmes Skylar C. , Heredia Caitlyn E. , Shumski Eric J. , Garcia Steven A. , Montgomery Melissa M. 
Published: September 2023

AbstractThe purpose was to (1) compare the effect of a walking bout on femoral cartilage deformation between limbs with and without anterior cruciate ligament reconstruction (ACLR) and (2) examine the association between gait kinetics and the magnitude of cartilage deformation. A total of 30 individuals with primary unilateral ACLR completed this study [14 male, 16 female; age = 22.57 (3.78) years; body mass index (BMI) = 25.88 (5.68) kg/m2; time since ACLR = 61.00 (16.43) months]. Overground walking biomechanics were assessed on day 1, and a 30‐min walking bout or 30‐min resting bout (control) were completed on days 2 and 3 (counterbalanced order). Femoral cartilage thickness was measured using ultrasound before, immediately following, and 30‐min following each intervention. Linear mixed effects models compared the effect of walking on cartilage thickness between the ACLR and contralateral limbs after adjusting for sex, BMI, speed, and the number of steps. Stepwise regression examined the association between the external knee flexion and adduction moments and cartilage deformation following walking. There was a significant limb × time interaction for medial cartilage thickness. Post hoc analyses indicated that cartilage thickness decreased immediately following walking in the contralateral but not ACLR limb. Main effects of limb were observed for medial, central, and lateral cartilage thickness indicating thicker cartilage in the ACLR compared with contralateral limb. A higher knee adduction moment was associated with greater cartilage deformation in the ACLR limb. Femoral cartilage in the ACLR limb exhibited a less dynamic response to walking than the uninvolved limb, which may be due to habitual underloading during gait.
Limited extension of the MIS 2 proglacial lake in the Severnaya Dvina valley, south‐eastern margin of the last Scandinavian Ice Sheet
Authors: Zaretskaya Nataliya , Utkina Anna , Baranov Dmitrii , Panin Andrei , Trofimova Svetlana , Simakova Aleksandra , Kurbanov Redzhep 
Published: September 2023

ABSTRACTThe Severnaya Dvina River valley crosses the former south‐eastern margin of the last Scandinavian Ice Sheet. Despite a long research history, there remains considerable controversy about the maximum ice‐sheet extent and the expansion of proglacial lakes within the Severnaya Dvina fluvial system. The goal of this study was to address these issues using new material from the valleys of the Severnaya Dvina and the lower Vychegda, thereby contributing to an understanding of the history of the south‐eastern sector of the last Scandinavian Ice Sheet and its periglacial areas. We studied a number of geological sections using radiocarbon and optically stimulated luminescence (OSL) dating, pollen and carpological analyses, and found that the Last Glacial Maximum (LGM) proglacial lake occupied the Severnaya Dvina valley between 20–19 ka and about 15.5 ka. The lake was localized within the proglacial isostatic depression and occupied only the Severnaya Dvina valley extending no further than the confluence of the Vychegda River, no more than 110 km from the edge of the ice sheet. The lake formation did not cause any drainage reorganization within and outside the Vychegda fluvial system. Given the small size of the lake and presence of the oldest OSL ages along the entire length of the former lake, we suggest that the onset of the proglacial lake marks the maximum extent of the ice sheet in the area. Consequently, the onset of the local LGM may be dated to 20–19 ka, somewhat earlier than assumed by most previous researchers. The LGM ice sheet boundary was located in the Severnaya Dvina valley downstream from the Vychegda confluence and did not extend into the Vychegda valley, despite previous suggestions. During deglaciation, the lake disappearance together with crustal rebound caused an incision episode in the Vychegda – Severnaya Dvina system and the formation of the Lateglacial alluvial terrace with relative height rising downstream due to the uneven rates of the postglacial uplift.
Use of multiple covariates in assessing treatment‐effect modifiers: A methodological review of individual participant data meta‐analyses
Authors: Godolphin Peter J. , Marlin Nadine , Cornett Chantelle , Fisher David J. , Tierney Jayne F. , White Ian R. , Rogozińska Ewelina 
Published: September 2023

AbstractIndividual participant data (IPD) meta‐analyses of randomised trials are considered a reliable way to assess participant‐level treatment effect modifiers but may not make the best use of the available data. Traditionally, effect modifiers are explored one covariate at a time, which gives rise to the possibility that evidence of treatment‐covariate interaction may be due to confounding from a different, related covariate. We aimed to evaluate current practice when estimating treatment‐covariate interactions in IPD meta‐analysis, specifically focusing on involvement of additional covariates in the models. We reviewed 100 IPD meta‐analyses of randomised trials, published between 2015 and 2020, that assessed at least one treatment‐covariate interaction. We identified four approaches to handling additional covariates: (1) Single interaction model (unadjusted): No additional covariates included (57/100 IPD meta‐analyses); (2) Single interaction model (adjusted): Adjustment for the main effect of at least one additional covariate (35/100); (3) Multiple interactions model: Adjustment for at least one two‐way interaction between treatment and an additional covariate (3/100); and (4) Three‐way interaction model: Three‐way interaction formed between treatment, the additional covariate and the potential effect modifier (5/100). IPD is not being utilised to its fullest extent. In an exemplar dataset, we demonstrate how these approaches lead to different conclusions. Researchers should adjust for additional covariates when estimating interactions in IPD meta‐analysis providing they adjust their main effects, which is already widely recommended. Further, they should consider whether more complex approaches could provide better information on who might benefit most from treatments, improving patient choice and treatment policy and practice.
Catchii: Empowering literature review screening in healthcare
Authors: Halman Andreas , Oshlack Alicia 
Published: September 2023

AbstractA systematic review is a type of literature review that aims to collect and analyse all available evidence from the literature on a particular topic. The process of screening and identifying eligible articles from the vast amounts of literature is a time‐consuming task. Specialised software has been developed to aid in the screening process and save significant time and labour. However, the most suitable software tools that are available often come with a cost or only offer either a limited or a trial version for free. In this paper, we report the release of a new software application, Catchii, which contains all the important features of a systematic review screening application while being completely free. It supports a user at different stages of screening, from detecting duplicates to creating the final flowchart for a publication. Catchii is designed to provide a good user experience and streamline the screening process through its clean and user‐friendly interface on both computers and mobile devices. All in all, Catchii is a valuable addition to the current selection of systematic review screening applications. It enables researchers without financial resources to access features found in the best paid tools, while also diminishing costs for those who have previously relied on paid applications. Catchii is available at https://catchii.org.
Investigation of antioxidant and sensory properties and in vitro bioaccessibility of low‐fat functional cookies substituted with wheat germ flour and coffee silverskin
Authors: Büyük Zülal , Dulger Altiner Dilek 
Published: September 2023

AbstractBACKGROUNDThis study aimed to produce new functional cookies with high nutritional properties and low calorie content. It investigated the effects of incorporating wheat germ flour (WGF) at levels of 10–30% as a substitute for whole wheat flour (WWF), along with coffee silver skin (CSS) in the same proportions, serving as natural functional additives to substitute for fat in cookie formulations.RESULTSThe total phenol content of the cookies with added WGF‐CSS ranged from 1813.72 to 1838.45 mg gallic acid equivalent (GAE) per kilogram of dry weight (mg GAE kg−1), whereas the total phenolic bioaccessibility values ranged between 53.39 and 56.84%. Of the three methods used to determine antioxidant capacity (AC), the cupric reducing antioxidant capacity (CUPRAC) method gave higher bioaccessibility values (44.55–51.19%) than the 2,2′‐azino‐bis (3‐ethylbenzthiazoline‐6‐sulfonic acid) (ABTS) radical cation and 2,2‐diphenyl‐1‐picrylhidrazyl (DPPH) scavenging methods. The contribution of WGF‐CSS supplemented cookies to the recommended dietary allowances (RDA) (%) of K, P, Mg, and Ca increased depending on the number of cookies consumed and the WGF and CSS ratio. The general acceptability scores of the cookies varied between 5.66 and −7.08, and the 10% WGF cookie (F2) (6.48) sample received the score that was closest to that of the control. Moderately strong positive relationships (r > 0.90, P < 0.05) were detected between the physicochemical and sensory characteristics of the cookies.CONCLUSIONAs a result, WGF and CSS food additives with high nutritional properties can be recommended as potential enriching ingredients and fat substitutes in the development of new products in the functional food industry. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Intra‐ and Interobserver Reliability of Shear Wave Elastography in Breast Cancer Diagnosis
Authors: Togawa Riku , Pfob André , Büsch Christopher , Fastner Sarah , Gomez Christina , Goncalo Manuela , Hennigs André , Killinger Kristina , Nees Juliane , Riedel Fabian , Schäfgen Benedikt , Stieber Anne , Tozaki Mitsuhiro , Heil Jörg , Barr Richard , Golatta Michael 
Published: September 2023

ObjectivesShear wave elastography (SWE) is increasingly used in breast cancer diagnostics. However, large, prospective, multicenter data evaluating the reliability of SWE is missing. We evaluated the intra‐ and interobserver reliability of SWE in patients with breast lesions categorized as BIRADS 3 or 4.MethodsWe used data of 1288 women at 12 institutions in 7 countries with breast lesions categorized as BIRADS 3 to 4 who underwent conventional B‐mode ultrasound and SWE. 1243 (96.5%) women had three repetitive conventional B‐mode ultrasounds as well as SWE measurements performed by a board‐certified senior physician. 375 of 1288 (29.1%) women received an additional ultrasound examination with B‐mode and SWE by a second physician. Intraclass correlation coefficients (ICC) were calculated to examine intra‐ and interobserver reliability.ResultsICC for intraobserver reliability showed an excellent correlation with ICC >0.9, while interobserver reliability was moderate with ICC of 0.7. There were no clinically significant differences in intraobserver reliability when SWE was performed in lesions categorized as BI‐RADS 3 or 4 as well as in histopathologically benign or malignant lesions.ConclusionReliability of additional SWE was evaluated on a study cohort consisting of 1288 breast lesions categorized as BI‐RADS 3 and 4. SWE shows an excellent intraobserver reliability and a moderate interobserver reliability in the evaluation of solid breast masses.
Rare methanotrophs adapt to broader environmental gradients than abundant methanotrophs in the riparian zone of the Three Gorges Reservoir
Authors: Jiajia Li , Arif Muhammad , Changxiao Li 
Published: September 2023

AbstractSoil communities are intricately linked to ecosystem functioning. Uncovering the responses of rare and abundant taxa to environmental change is vital for understanding methanotrophic community assembly and ecosystem function. It is unclear what the proportions of the different taxa are in riparian soil and how environmental change may impact these, and thereby affect the structure and assembly of different communities. Considering both abundant and rare taxa, we investigated environmental thresholds and phylogenetic signals related to the ecological preferences of methanotrophic communities under complex environmental gradients, and explore the factors that influence their assembly. It has ecological significance for predicting how communities will gather in response to changing environmental conditions. It was found that methanotrophs had different ecological network patterns across land‐use types, with the network complexity of abundant taxa being higher in grasslands and woodlands than that of rare taxa. Different ecological preference thresholds and phylogenetic signals were observed between abundant and rare subcommunities in the riparian zone, with rare taxa possessing potentially broader environmental adaptation capabilities. Rare taxa were phylogenetically clustered closer together than abundant taxa. The assembly of abundant taxa was dominated by stochastic processes, whereas the assembly of rare taxa was dominated by deterministic processes. Soil pH played an important role in regulating the balance between the assembly processes of abundant and rare subcommunities. The deterministic assembly of rare taxa and the stochastic assembly of abundant taxa increased with pH values. We revealed the complexity of a co‐occurring ecological network, identified the mediators of methanotrophic community assembly, and examined the adaptability of rare and abundant methanotrophic species to different environmental gradients. These findings indicate that it is possible to predict the generation and maintenance of methanotrophic community diversity by studying how methanotrophs will respond to environmental changes in the riparian zone during vegetation restoration projects.
Estimating sediment yield from a small urban catchment of a heterogeneous structure
Authors: Krajewski Adam , Hejduk Leszek , Sikorska‐Senoner Anna E. 
Published: September 2023

AbstractSmall urban areas, due to their specificity (high anthroposphere, multiple forms of land use, variable drainage conditions), are often overlooked in studies on soil erosion and sediment transport that predominantly focus on a large scale. The sediment yield from such small urban areas may greatly vary depending, for example, on the state of the land development. Therefore, its proper estimation is crucial for water resources management, improving urban runoff quality or designing and maintaining local retention ponds. In this study, two different approaches were applied to estimate sediment yield from a small urban catchment of Służew Creek, located in Warsaw, Poland. While the first was based on direct hydrological measurements and field samples, the second (indirect) used various empirical formulas to predict bed load transport (local formula of Skibiński) in the stream channel and the suspended sediment delivery from the catchment (USLE equation, Build‐up/Wash‐off model). The sediment load established according to the direct approach equals 714 Mg/year, of which 83 Mg/year results from the bed load transport and 631 Mg/year comes from the suspended sediment transport. The total sediment load calculated according to the indirect approach equals 579 Mg/year. The relative difference in loads calculated with these two methods is about 20%. This paper combines various established methods into a novel composite analysis of sediment yield. The methodology presented in this study may support the estimation of sediment load in small urban catchments with a heterogenous land use structure. Hence, it may support urban planning and water resources management in such small catchments.