bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteocalcin is associated with triglyceride glucose index rather than HOMA-IR in men with type 2 diabetes
Authors: Huang Huijie , Wang Ai , Cong Li , Zeng Yingjuan 
Published: December 2022

IntroductionThe involvement of osteocalcin in the regulation of glucose tolerance in humans is controversial. We utilized a novel and practical insulin resistance surrogate, the triglyceride-glucose (TyG) index, to investigate the association between serum osteocalcin and insulin resistance in men with type 2 diabetes (T2D).MethodsThis was a retrospective cross-sectional study that included 667 male patients suffering from T2D, with measurements of N-terminal mid-fragment of osteocalcin (N-MID), triglycerides (TG), fasting blood glucose (FBG) and C-peptide collected on the same day. We used the TyG index and HOMA-IR as surrogate measures for insulin resistance. Binary logistic regression models that adjust the sociodemographic characteristics and metabolism-related factors were used to assess the associations between osteocalcin and insulin resistance. Restricted cubic spline (RCS) analysis was used to test the potential non-linear relationship between N-MID and the risk of severe insulin resistance. Subgroup analysis evaluated the robustness of the association.ResultsN-MID was correlated with the level of insulin resistance when quantified by the TyG index in unadjusted and adjusted binary logistic regression models (all p &lt; 0.05), but the relationship was not observed when assessed by HOMA-IR (all p &gt; 0.05). RCS model further confirmed that the association between N-MID and the severe insulin resistance measured by the TyG index was non-linear (P = 0.047). Subgroup analysis showed that the association was detected only in younger patients with lower BMI and poorer glycemic control, without hypertension or smoking.ConclusionsOsteocalcin was inversely associated with the TyG index in men with T2D.
Circulating brain-derived extracellular vesicles expressing neuroinflammatory markers are associated with HIV-related neurocognitive impairment
Authors: de Menezes Erika G. Marques , Liu Jocelyn S. , Bowler Scott A. , Giron Leila B. , D’Antoni Michelle L. , Shikuma Cecilia M. , Abdel-Mohsen Mohamed , Ndhlovu Lishomwa C. , Norris Philip J. 
Published: December 2022

BackgroundNeurocognitive impairment remains prevalent in people with HIV (PWH) despite long term virological suppression by antiretroviral therapy (ART) regimens. Systemic and neuro-inflammatory processes are suggested to contribute to the complex pathology leading to cognitive impairment in this population, yet the underlying mechanisms remain unresolved. Extracellular vesicles (EVs) play a central role in intracellular communication and have emerged as key modulators of immunological and inflammatory responses. In this report, we examined the impact of EVs in PWH experiencing cognitive deficits to determine their relevance in HIV associated neuropathology.MethodsEV phenotypes were measured in plasma samples from 108 PWH with either cognitive impairment (CI, n=92) or normal cognition (NC, n=16) by flow cytometry. Matched cerebrospinal fluid (CSF)-derived EVs were similarly profiled from a subgroup of 84 individuals who underwent a lumbar puncture. Peripheral blood mononuclear cells were assayed by flow cytometry to measure monocyte frequencies in a subset of 32 individuals.ResultsPlasma-EVs expressing CD14, CD16, CD192, C195, and GFAP were significantly higher in HIV-infected individuals with cognitive impairment compared to individuals with normal cognition. Increased CSF-EVs expressing GFAP and CD200 were found in the cognitive impairment group compared to the normal cognition group. Frequencies of patrolling monocytes correlated with plasma-EVs expressing CD14, CD66b, MCSF, MAP2, and GFAP. Frequencies of CD195 expression on monocytes correlated positively with plasma-EVs expressing CD41a, CD62P, and CD63. Expression of CD163 on monocytes correlated positively with CSF-EVs expressing GFAP and CD200. Finally, the expression of CD192 on total monocytes correlated with CSF-EVs expressing CD200, CD62P, and CD63.ConclusionsEVs expressing monocyte activation and neuronal markers associated with HIV associated cognitive impairment, suggesting that distinct EV subsets may serve as novel biomarkers of neuronal injury in HIV infection. Further circulating platelet EV levels were linked to monocyte activation indicating a potential novel interaction in the pathogenesis of HIV-related cognitive impairment.
Early calcineurin-inhibitor to belatacept conversion in steroid-free kidney transplant recipients
Authors: Tawhari Ibrahim , Hallak Patrick , Bin Sofia , Yamani Fatmah , Safar-Boueri Maria , Irshad Aazib , Leventhal Joseph , Ansari Mohammed Javeed , Cravedi Paolo , Gallon Lorenzo 
Published: December 2022

BackgroundBelatacept (Bela) was developed to reduce nephrotoxicity and cardiovascular risk that are associated with the chronic use of Calcineurin inhibitors (CNIs) in kidney transplant recipients. The use of Bela with early steroid withdrawal (ESW) and simultaneous CNI avoidance has not been formally evaluated.MethodsAt 3 months post-transplant, stable kidney transplant recipients with ESW on Tacrolimus (Tac) + mycophenolate (MPA) were randomized 1:1:1 to: 1) Bela+MPA, 2) Bela+low-dose Tac (trough goal &lt;5 ng/mL), or 3) continue Tac+MPA. All patients underwent surveillance graft biopsies at enrollment and then at 12, and 24 months post-transplant. Twenty-seven recipients were included; 9 underwent conversion to Bela+MPA, 8 to Bela+low-dose Tac and 10 continued Tac+MPA. Serial blood samples were collected for immune phenotyping and gene expression analyses.ResultsThe Bela+MPA arm was closed early due to high rate of biopsy proven acute rejection (BPAR). The incidence of BPAR was 4/9 in Bela+MPA, 0/8 in Bela+low dose Tac and 2/10 in Tac+MPA, P= 0.087. The Bela+low-dose Tac regimen was associated with +8.8 mL/min/1.73 m2increase in eGFR compared to -0.38 mL/min/1.73 m2in Tac+MPA, P= 0.243. One graft loss occurred in the Bela+MPA group. Immunophenotyping of peripheral blood monocyte count (PBMC) showed that CD28+CD4+and CD28+CD8+T cells were higher in Bela+MPA patients with acute rejection compared to patients without rejection, although the difference did not reach statistical significance.ConclusionsOur data indicate that, in steroid free regimens, low-dose Tac maintenance is needed to prevent rejection when patients are converted to Bela, at least when the maneuver is done early after transplant.
Arginine as the sole nitrogen source for Ostreococcus tauri growth: Insights on nitric oxide synthase enzyme
Authors: Foresi Noelia , Caló Gonzalo , Del Castello Fiorella , Nejamkin Andres , Salerno Graciela , Lamattina Lorenzo , Martínez-Noël Giselle , Correa-Aragunde Natalia 
Published: December 2022

IntroductionPhotosynthetic organisms respond to nitrogen (N) deprivation with the slowdown of photosynthesis and electron transport resulting in the balance the carbon (C)/N ratio. Under this extreme condition, organisms trigger complex mechanisms to keep growing using different N sources and recycling N containing molecules. In particular, phytoplankton are able to uptake L-arginine (L-Arg) as an organic N source. L-Arg can be assimilated mainly by the arginase, arginine deimidase, arginine decarboxylase or L-amino oxidase pathways.ResultsWe analyzed the effect of different N sources on the growth of the green algae Ostreococcus tauri. N starvation caused an inhibition of culture growth and a decrease in chlorophyll content. The addition of L-Arg to an N-deprived medium promotes a sustained growth rate of O. tauri culture and the increase of chlorophyll levels. The transcript level of genes involved in N uptake and metabolism were increased in N-starved condition while the addition of L-Arg as the sole N source reduced their induction. Since the O. tauri genome lacks the classical pathways to metabolize L-Arg, another enzyme/s may be responsible for L-Arg catabolism. Previously, we characterized the nitric oxide synthase (NOS) enzyme from O. tauri (OtNOS) which oxidizes L-Arg producing nitric oxide (NO) and citrulline. The NOS inhibitor L-NAME blocks the effect promoted by L-Arg on N-deprived O. tauri growth. Besides, NO level increased in O. tauri cells growing in L-Arg containing medium, suggesting the participation of OtNOS enzyme in L-Arg metabolism during N starvation.DiscussionOur hypothesis suggests that, after NOS-dependent Arg degradation, non-enzymatic oxidation of NO produces N oxides (mainly NO2-) that are re-incorporated to the N primary metabolism. As expected, N deprivation increases the lipid content in Ostreococcus. The addition of L-Arg or NO2- as the sole N sources showed a similar increase in lipid content to N deprivation. In summary, our results demonstrate that L-Arg is able to function as N source in Ostreococcus. The evidences on an alternative pathway of N supply and metabolism in a photosynthetic microorganism are discussed. These results could also allow the development of biotechnological tools for increasing lipid production for industry.
A machine learning-based approach to predicting the malignant and metastasis of thyroid cancer
Authors: Gu Jianhua , Xie Rongli , Zhao Yanna , Zhao Zhifeng , Xu Dan , Ding Min , Lin Tingyu , Xu Wenjuan , Nie Zihuai , Miao Enjun , Tan Dan , Zhu Sibo , Shen Dongjie , Fei Jian 
Published: December 2022

BackgroundThyroid Cancer (TC) is the most common malignant disease of endocrine system, and its incidence rate is increasing year by year. Early diagnosis, management of malignant nodules and scientific treatment are crucial for TC prognosis. The first aim is the construction of a classification model for TC based on risk factors. The second aim is the construction of a prediction model for metastasis based on risk factors.MethodsWe retrospectively collected approximately 70 preoperative demographic and laboratory test indices from 1735 TC patients. Machine learning pipelines including linear regression model ridge, Logistic Regression (LR) and eXtreme Gradient Boosting (XGBoost) were used to select the best model for predicting deterioration and metastasis of TC. A comprehensive comparative analysis with the prediction model using only thyroid imaging reporting and data system (TI-RADS).ResultsThe XGBoost model achieved the best performance in the final thyroid nodule diagnosis (AUC: 0.84) and metastasis (AUC: 0.72-0.77) predictions. Its AUCs for predicting Grade 4 TC deterioration and metastasis reached 0.84 and 0.97, respectively, while none of the AUCs for Only TI-RADS reached 0.70. Based on multivariate analysis and feature selection, age, obesity, prothrombin time, fibrinogen, and HBeAb were common significant risk factors for tumor progression and metastasis. Monocyte, D-dimer, T3, FT3, and albumin were common protective factors. Tumor size (11.14 ± 7.14 mm) is the most important indicator of metastasis formation. In addition, GGT, glucose, platelet volume distribution width, and neutrophil percentage also contributed to the development of metastases. The abnormal levels of blood lipid and uric acid were closely related to the deterioration of tumor. The dual role of mean erythrocytic hemoglobin concentration in TC needs to be verified in a larger patient cohort. We have established a free online tool (http://www.cancer-thyroid.com/) that is available to all clinicians for the prognosis of patients at high risk of TC.ConclusionIt is feasible to use XGBoost algorithm, combined with preoperative laboratory test indexes and demographic characteristics to predict tumor progression and metastasis in patients with TC, and its performance is better than that of Only using TI-RADS. The web tools we developed can help physicians with less clinical experience to choose the appropriate clinical decision or secondary confirmation of diagnosis results.
The effect of exercise intention on exercise behavior in the post-epidemic era: The moderator role of openness personality and the mediated role of exercise-induced feeling
Authors: Ma Qi-Shuai , Yao Shu-Jun , Jia Hua-Rui 
Published: December 2022

ObjectiveBased on the theory of planned behavior, this study introduced personality traits and exercise-induced feelings and other third variables, aiming to explore the mechanism of personality traits and exercise-induced feelings between exercise intention and exercise behavior, and explore the internal mechanism of promoting exercise behavior of junior high school students.MethodsThis research adopts the Exercise Intention Questionnaire, Simple Big Five Personality Scale, Exercise-induced Feeling Inventory and Exercise Rating Scale, from the three cities of Anhui province 1,166 junior high school students selected from the group psychological measurement, and uses the SPSS23.0 and Process plug-in exercise intention in exercise behavior analysis of the direct and indirect effect.ResultsThe results showed that: (1) Exercise intention significantly positively predicted exercise behavior (β = 0.265, t = 4.261, p &lt; 0.01). (2) The moderating effect of openness personality between exercise intention and exercise behavior was significant (β = 0.093, t = 4.431, p &lt; 0.01). (3) Exercise-induced feelings has a significant mediating effect on the relationship between exercise intention and exercise behavior regulated by openness personality.ConclusionExercise intention can effectively predict exercise behavior, and the prediction level is affected by openness personality, and the moderating effect of openness personality is partially realized through the mediating variable of exercise-induced feelings.
Correlation of safety behavior, handover quality, and risk perception: A cross-sectional study among Chinese psychiatric nurses
Authors: Liu Yakun , Teng Weiyu , Chen Chen , Zou Guiyuan 
Published: December 2022

BackgroundNurses’ safety behaviors played an important role in patients’ safety goal realization, and it varies from person to person. However, less research has explored the safety behavior level of psychiatric nurses and its influencing factors. Thus, this research aimed to assess the level of safety behavior and explore whether risk perception mediated the relationship between handover quality and safety behavior among psychiatric nurses.MethodsA total of 186 registered psychiatric nurses in a Chinese hospital were recruited for this study, through the convenience sampling method. Handover quality, risk perception, and safety behavior were measured. Hayes’ PROCESS macro was used to evaluate the mediation of risk perception between handover quality and safety behavior.ResultsScores of psychiatric nurses’ safety behaviors were (47.98 ± 7.45), and handover quality and risk perception could predict the variance of nurses’ safety behaviors. Risk perception could partially mediate between handover quality and nurses’ safety behaviors, and the value of the mediating effect was 49.17%.ConclusionPsychiatric nurses’ safety behaviors have a large promotion space. Therefore, healthcare professionals should endeavor to improve the handover quality of psychiatric nurses and decrease their risk perception, thereby promoting nurses’ safety behaviors.
Goal planning in mental health service delivery: A systematic integrative review
Authors: Stewart Victoria , McMillan Sara S. , Hu Jie , Ng Ricki , El-Den Sarira , O’Reilly Claire , Wheeler Amanda J. 
Published: December 2022

IntroductionGoal planning is routinely employed in mental health service delivery to identify priorities for treatment and support the achievement and evaluation of outcomes. Previous systematic reviews of the literature have focused on the use of goal planning in a range of physical and cognitive disability settings, but there is a lack of information regarding how goal planning is used in mental healthcare.AimsThis systematic integrative review aimed to understand the types of goals, effectiveness of goal planning, the experience of goal planning and barriers and facilitators to effective goal planning in mental healthcare settings.MethodsFive databases were systematically searched using key terms related to mental health AND goal planning. The search was supplemented through citation chaining. Due to the heterogeneity of the studies, a narrative synthesis approach to data analysis was undertaken.ResultsFifty-four studies were identified through the search of the literature following the PRISMA guidelines. Data was systematically extracted and thematically organized. There was a high level of heterogeneity among the studies, originating from a range of countries and with diverse characteristics and focus. Four themes emerged from the data analysis and included: (i) goal planning as a central aspect of interventions; (ii) types of goals planned; (iii) factors that influenced goal planning and/or attainment; and (iv) collaboration and concordance in goal planning.ConclusionThis review found some support for the use of goal planning to improve outcomes in mental healthcare although there was no identified standardized approach to the use of goal planning. Individualized, recovery-oriented and collaborative goal planning was recommended but not always used in practice. Further research to understanding the most appropriate skills and training needed to support collaborative and effective goal planning is needed.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42020220595].
Safety and feasibility of performing robotic ureteroureterostomy and robotic pyeloplasty in infants
Authors: Suarez Arbelaez Maria Camila , Ghattas Yasmine , Raymo Adele , Isern Samantha , Alam Alireza , Nassau Daniel E. , Castellan Miguel 
Published: December 2022

IntroductionOpen surgery is considered the standard of care for pediatric urological procedures. Nonetheless, Robotic Assisted Laparoscopic Surgeries (RALS) have become increasingly popular in pediatrics as they allow for quicker recovery times, lower narcotic use, better cosmesis, and better intraoperative visibility. However, there are concerns regarding the usefulness of RALS in the infant population, as operating on smaller patients limits mobility of the robotic arms and can result in arm collisions.ObjectiveThe aim of this study was to compare the clinical and postoperative outcomes of infants undergoing robotic vs open pyeloplasty or ureteroureterostomy.Materials and MethodsRetrospective study conducted between 2012 to 2022, 114 infants who underwent pyeloplasty (81 open pyeloplasty and 33 robotic pyeloplasty) and 21 who underwent ureteroureterostomy (9 open ureteroureterostomy and 12 robotic ureteroureterostomy) were included.ResultsMean age at surgery in the pyeloplasty cohort was 4.81 ± 3.1 months in the open group, and 6.24 ± 2.6 months in the robotic group (p=0.13), and in the ureteroureterostomy cohort was 7.67 ± 3.16 months in the open group and 7.58 ± 2.75 months in the robotic group (p=0.95). Operative time was found to be shorter in robotic pyeloplasty and robotic ureteroureterostomy, when compared to the open approaches. Postoperative complications, its severity, and the surgical success were comparable among the pyeloplasty and ureteroureterostomy groups. Only 1(3%) complication related to the robotic technique was reported in the pyeloplasty cohort. The length of hospital stay was found to be similar between the ureteroureterostomy groups, while in the pyeloplasty cohort the robotic group showed a significant shorter hospital stay than the open group. Overall, the mean follow-up was greater than 12 months.ConclusionOur results demonstrated that robotic pyeloplasty and ureteroureterostomy performed in infants are feasible, safe, and durable procedures, with an additional benefit of reducing duration of operative time and hospital stay.
PENGARUH METODE SCHOOL WATCHING TERHADAP KESIAPSIAGAAN SISWA SD DALAM MENGHADAPI BENCANA DI KECAMATAN CICENDO KOTA BANDUNG
Authors: Meilianingsih Lia , Sugiyanto Sugiyanto 
Published: December 2022

Provinsi Jawa Barat memiliki tingkat kerawanan bencana paling tinggi di Indonesia yang di dominasi oleh kejadian tanah longsor, banjir dan kebakaran. Kelompok yang sangat rentan terhadap bencana adalah anak-anak. Anak-anak sekolah dasar rata-rata menghabiskan waktu 7 jam di sekolah. Sehingga sekolah dapat dikategorikan sebagai tempat yang rawan bencana. Bencana dapat terjadi setiap saat termasuk pada saat anak di sekolah. Anak sekolah harus memiliki ketangguhan dalam menghadapi ancaman bencana. School Watching merupakan salah satu metode yang dapat membantu peserta didik dalam meningkatkan kesiapsiagaan bencana melalui kegiatan yang dilakukan di sekolah dan lingkungan sekitarnya. Penelitian ini bertujuan untuk mengetahui pengaruh metode school watching terhadap kesiapsiagaan siswa SD dalam menghadapi bencana di Kecamatan Cicendo Kota Bandung. Desain penelitian menggunakan quasi experiment dengan pendekatan Pre Post test control group design. Sampel Penelitian ini siswa kelas V SD di Kecamatan Cicendo. Besar sampel berjumlah 39 orang untuk kelompok intervensi dan 39 orang untuk kelompok kontrol. Teknik pengambilan sampel dengan cara proportional Random sampling. Intervensi diberikan dalam 5 kali pertemuan. Kegiatan intervensi meliputi: pemberian materi tentang kebencanaan, pengamatan, pemetaan, diskusi dan presentasi. Analisis data yang digunakan untuk kelompok berpasangan menggunakan uji statistik T test dependent karena data berdistribusi normal. Sedangkan untuk kelompok tidak berpasangan menggunakan uji Mann-Whitney karena data berdistribusi tidak normal. Hasil penelitian menunjukkan terdapat pengaruh metode school watching terhadap kesiapsiagaan siswa SD dalam menghadapi bencana karena didapatkan p value 0,000. Oleh karena itu disarankan kepada penanggung jawab program kesehatan sekolah untuk menerapkan metode school watching untuk mengurangi resiko bencana di komunitas sekolah.
ASPECTS OF THE IMPORTANCE OF FIRST METATARSOPHALANGEAL JOINT IN THE PROCESS OF GAIT RECOVERY
Authors: Murgoci Nicolae , Mereuță Claudiu 
Published: December 2022

The purpose of the present scientific research is to take into consideration the importance of rehabilitation of the first metatarsophalangeal joint in the process of physio cycling in order to recover the gait. Hypothesis: patients over 55 age has hallux rigidus that determine the vicious angulation of the ankle by reduction of the normal range of motion. The aim of this research is to analyses the possibility of applying kinetic programs for the first metatarsophalangeal joint too, in the process of horizontal cycling. Recovering the independence of gait in order to improve the quality of life it is a crucial factor of rehabilitation. Materials and Methods: 19 patients over 55 years age, period November 2020- March 2021 diagnosed with different pathologies (excluding amputation) that affects lower limbs and with indication for physiotherapy and Visual Analog Scale maxim 4. Determination of active dorsiflexion and active plantarflexion of the first metatarsophalangeal joint was proceed according to American Medical Association scale of grading. Pearson correlation between right and left foot of the first metatarsophalangeal joint are strong. The most common grade is 3 both for left and right foot on dorsiflexion and plantarflexion, approximately equal distribution on gender. Kinetic program can be used only for the first 3 grades according AMA and hallux rigidus severity grades 0-2. In the process of gait recovery may be possible physiotherapy for 12 patients for the 1st MTF joint among the other programs for kinetic chain.