bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Parasitaemia and Anemia in Mice Infected with Plasmodium berghei ANKA
Authors: Azizah Inas Hasna , Bahi Stevani Florentia , Arwati Heny , Mufassirin Mufassirin 
Published: March 2023

Malaria is an infectious disease caused by protozoa of the genus Plasmodium and transmitted through the bite of a female Anopheles mosquito. Plasmodium berghei ANKA is a species of rodent malaria parasite that is commonly used to study malaria pathology and the immune system against infections. Parasitaemia in malaria is the figure of malaria pathology due to some numbers of parasite-infected erythrocytes present in the peripheral blood. Hemoglobin (HGB) and hematocrit (HCT) levels are the parameters of anemia and some hematological changes caused by malaria infection. This study aimed to determine the correlation between parasitemia and anemia in BABL/c mice infected with Plasmodium berghei ANKA. Two uninfected and infected mice groups were compared for parasitemia, HGB, and HCT levels. Analysis statistics showed a significant difference in HGB and HCT between uninfected and infected groups. Pearson correlation analysis showed no significant correlation between parasitemia and HGB and HCT levels in infected mice. Anemia in mice infected with Plasmodium berghei ANKA can occur when parasitemia is even low; the higher parasitemia worsens the hamatological condition. Parasitemia plays a role independently in the severity of anemia. Plasmodium berghei infection in mice is useful for studying malaria anemia.
STUDENTS’ ATTITUDES AND PROBLEMS ON QUESTION-BASED ARGUMENTATIVE ESSAY WRITING INSTRUCTION
Authors: Seyoum Wubante Mekonnen , Yigzaw Abiy , Bewuketu Haile Kassahun 
Published: March 2023

Teaching argumentative essay writing to students through questioning is prominent to provide them with sufficient skills to compete in this world. Having this in mind, this descriptive study was conducted to identify students’ attitudes and their common problems in practicing argumentative essay writing skills through questioning method at DMU, in Ethiopia. To fulfill the purpose of this study, sixty management students answered the questionnaire. The results from the questionnaire revealed that all students have positive attitudes towards using the method while practicing writing. The data also revealed that inappropriate teaching method, time constraints, and large class size were the most common problems that did not allow students to apply their argumentative essay writing skills through questioning method effectively. This study recommends educators, policymakers, and other stakeholders to reconsider the attitudes and problems of university students while designing question-based argumentative essay writing teaching materials.
THE CORRELATION BETWEEN ANXIETY AND STUDENT GPA & EPT SCORE DURING COVID 19 PANDEMIC
Authors: Akhdan Masagus Abdullah , Aminatun Dyah 
Published: March 2023

One of the problems and inhibitions of students’ learning development is anxiety. Students’ in Indonesia learn online from home in an effort to limit social restrictions during the pandemic covid-19. From this online learning, there is also anxiety felt by students’. The purpose of this study is to find out what are the anxieties felt by students’ in online learning during this pandemic that have an correlation with their last GPA score and EPT (English proficiency test) score. This research was designed using quantitative correlational study with independent variables. The data of this study was taken from English Education Students’ of Universitas Teknokrat Indonesia and the sample obtained in this study was 39 students’ who take Quantitative Research class. The instruments used in collecting the data are questionnaire and the last GPA EPT score. Statistical analysis of Pearson product-moment correlation and SPSS software was used to find the correlation between the variables. The result of this study showed that there were negative correlation between anxiety and students’ GPA and EPT scores. The correlation was 0.925, and the t-table was lower than the T-test. As a result, it is entirely possible to conclude that anxiety has a statistically significant impact on student achievement.
PENGEMBANGAN BAHAN AJAR PERMAINAN BOLA BESAR SEBAGAI SUMBER BELAJAR DI SMA NEGERI 1 TRIMURJO
Authors: Ginantara Alfayreza , Aguss Rachmi Marsheilla 
Published: March 2023

The purpose of this study was to develop, analyze the feasibility and analyze the responses of teachers and students to the developed product. This study uses the ADDIE development model. The test subjects in this study were one teacher and ten students of class X MIA SMA Negeri 1 Trimurjo. The data analysis technique in this research is quantitative and qualitative data analysis. The results of product validation by material experts were carried out three times, obtained a percentage score of 78,75% (Valid), while the results of media expert validation were carried out twice, obtained a percentage score of 90% (Very valid). The results of the teacher’s response obtained a percentage score of 85% (Very valid) and the results of student responses obtained a percentage score of 93% (Very valid). Based on the results of the feasibility assesment, the average percentage score was 86,7%, so it can be concluded that the big ball game teaching materials product developed is very suitable for use in physical education.
Genetically predicted circulating levels of cytokines and the risk of osteoarthritis: A mendelian randomization study
Authors: Su Dalin , Ai Yanhong , Zhu Guoyong , Yang Yubiao , Ma Pengyi 
Published: March 2023

Background: The association between inflammatory cytokines and osteoarthritis (OA) has been reported in several observational studies, but the causal relationship between these two remains unknown. Hence, we performed this two-sample Mendelian randomization (MR) to confirm the causal relationship between circulating levels of inflammatory factors and osteoarthritis risk.Method: We used genetic variants associated with cytokine circulation levels from a meta-analysis of genome-wide association studies (GWASs) in 8,293 Finns as instrumental variables and obtained OA data from the United Kingdom Biobank, including a total of 345,169 subjects of European ancestry (66,031 diagnosed OA cases and 279,138 controls). Inverse variance weighting (IVW), MR-Egger, Wald Ratio, weighted median, and MR multiplicity residual sums with outliers (MR-PRESSO) were used.Result: We found a causal relationship between circulating levels of macrophage inflammatory protein-1beta (MIP-1β) and risk of OA (OR = 0.998, 95% CI = 0.996–0.999p = 9.61 × 10−5); tumour necrosis factor beta (TNF-β) was also causally associated with risk of OA (OR = 0.996,95%CI = 0.994–0.999, p = 0.002); finally we found a suggestive association between C-C motif chemokine ligand 5(CCL5, also called Rantes) and OA risk (OR = 1.013, 95%CI = 1.002–1.024,p = 0.016).Conclusion: Our findings offer promising leads for the development of new therapeutic targets in the treatment of osteoarthritis. By identifying the role of inflammatory cytokines in this debilitating condition through a genetic epidemiological approach, our study contributes to a better understanding of the underlying disease mechanisms. These insights may ultimately pave the way for more effective treatments that improve patient outcomes.
Serial viral load analysis by DDPCR to evaluate FNC efficacy and safety in the treatment of mild cases of COVID-19
Authors: da Silva Renato Martins , Gebe Abreu Cabral Paula , de Souza Sávio Bastos , Arruda Raul Ferraz , Cabral Sheila Passos de Figueiredo , de Assis Arícia Leone Evangelista Monteiro , Martins Yolanda Porto Muniz , Tavares Carlos Augusto de Araújo , Viana Junior Antônio Brazil , Chang Junbiao , Lei Pingsheng 
Published: March 2023

IntroductionThe SARS-CoV-2 outbreak has threatened the human population globally as the numbers of reinfection cases even after large-scale vaccination. Trials have been carried out to find drugs effective in fighting the disease, as COVID-19 is being considered a treatable disease only after we have antivirals. A clinical candidate originally developed for HIV treatment, AZVUDINE (FNC), is a promising drug in the treatment of COVID-19.MethodsTo predict the clinical outcome of COVID-19, we examined the course of viral load, every 48 h, by RT-PCR, and disease severity using an antiviral drug, FNC, with 281 participants. A randomized clinical trial was performed to evaluate the efficacy of FNC added to standard treatment, compared with placebo group added to standard treatment, for patients with mild COVID-19. RT-qPCR and ddPCR were applied to estimate the viral load in samples from patients. Also, the clinical improvement was evaluated as well as the liver and kidney function.Results and discussionNotably, the FNC treatment in the mild COVID-19 patients may shorten the time of the nucleic acid negative conversion (NANC) versus placebo group. In addition, the FNC was effective in reducing the viral load of these participants. The present clinical trial results showed that the FNC accelerate the elimination of the virus in and could reduce treatment time of mild patients and save a lot of medical resources, making it a strong candidate for the outpatient and home treatment of COVID-19.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT05033145, identifier NCT05033145.
Comparison of early caries diagnosis methods
Authors: Lytkina A. A. , Sarap L. R. , Gegamian A. O. , Zeibert A. Yu. , Kudrina K. O. 
Published: March 2023

Relevance. The question of diagnosing tooth decay and, thus, determining treatment methods is still very topical. There is a large number of techniques available for the diagnosis of dental caries in modern dentistry.Objective. The study aimed to compare different caries diagnosis methods to determine the most effective carious lesion detection.Material and methods. We examined in total 45 subjects, 1248 permanent teeth and 5700 tooth surfaces. The dental examination included three diagnostic techniques for each patient: visual-tactile, ICDAS II and quantitative light-induced fluorescence (QLF). The data were processed and presented graphically using Statistica 12.0 (Stat-Soft) and Microsoft Office Excel 2017 software.Results. According to the DMFS index, in the visual-tactile group, the "D" (decayed) was 3.00 ± 0.02 and the "F" (filled) was 1.93 ± 0.02. Caries intensity in this study group was 6.27 ± 0.58. The ICDAS II examination detected the average caries intensity of 6.93 ± 0.56 (p1-2 < 0.001). There were 3.47 ± 0.02 (p1-2 < 0.001) carious lesions. The "F" score was 2.13 ± 0.01 (p1-2 = 0.024). The QLF diagnostic method showed 7.44 ± 0.54 (p1-3 < 0.001, p2-3 = 0.006) as the mean intensity of caries in permanent teeth; there were 3.84 ± 0.02 (p1-3 < 0.001, p2-3 = 0.015) carious lesions and the "F" was 2.27 ± 0.01 (p1-3 = 0.018, p2-3 = 0.520). The "M" score was 0.27 ± 0.01 (p1-2 = 0.999, p1-3 = 0.999, p2-3 = 0.999), according to all applied techniques.Conclusion. The QLF method had the highest sensitivity and was superior to the visual-tactile method and ICDAS II.
Assessment of restoration quality of permanent teeth in children with different caries resistance degree
Authors: Shevchenko M. A. , Kiselnikova L. P. , Zueva T. E. , Juraeva N. I. 
Published: March 2023

Relevance. Caries prevalence and intensity in permanent teeth of children are increasing with age. It is common knowledge that secondary caries causes 57% of restoration replacements in children. Studying the risk of secondary caries onset in the child's permanent teeth is relevant.Purpose. To study the marginal fit of restorative material (composites and compomers) in per-manent teeth of children with different caries resistance degrees.Materials and methods. One-hundred-and-three children (167 teeth) aged 6 to 15 y.o. had clinical and labora-tory examinations and treatment. All children had dentine caries of permanent teeth (K02.1) treated. The carious cavities were filled with compomer and composite materi-al. We clinically assessed the restorative marginal integrity in each patient based on the intensity of the carious process by G.Ryge (1998) and laser fluorescence 1 and 2 years after the filling of cavities.Results. In children with average caries intensity and compomer restorations, the rate of resto-rations with secondary caries signs reached 72%, while the high caries intensity group demonstrated 32%. The group with average carious process intensity and composite restorations did not show any secondary caries signs; in the group with high carious process intensity, inadequate marginal integrity of restorations was in 41% of cases.Conclusion. Compomers are recommended for caries treatment in permanent teeth of children with high carious process intensity, while composites are for children with average carious process intensity. Laser fluorescence allows for the identification of diagnostically reli-able data detecting the loss of a significant amount of restorative material to the level of dentin-enamel junction.
Usability of KOHA OPAC by Undergraduate Users for Information Retrieval with Regard to Usability Testing in Technical University of Kenya Library
Authors: Nyambaka Steve Biko , Mutwiri Caroline 
Published: March 2023

The intention of this paper was to determine usability of KOHA OPAC in information retrieval with regard to usability testing by undergraduate users at Technical University of Kenya Library (TU-KL) in Nairobi County. Usability testing can be realized by way of assigning tasks to a representative of the user population in order to determine whether users can be able to achieve the desired goal of retrieving information. To a great extent, success will depend on how users perform the tasks assigned to them. This study conducted usability test on actual users of KOHA OPAC at Technical University of Kenya Library. Qualitative data was collected using the think aloud method where study participants were required to verbalize their thought process as they performed search and retrieval tasks using KOHA OPAC. The number of errors made, time taken to complete search and retrieval activities were coded, recorded and analysed during usability testing. This helped the researcher to determine whether KOHA OPAC is easy to use and whether it saves time for the user. Undergraduate students for the study were selected using a stratified random sampling technique. The population of the study (n = 382) was determined using a simplified formula developed by Yamane. The study initiated a usability test which presented search scenarios where participants were invited to participate in searching and retrieving information resources using KOHA OPAC. The results of the usability test of KOHA OPAC at TU-KL showed that users were slow at accomplishing search tasks, they took long duration to access TU-KL website that hosts KOHA OPAC and there was inefficiency in accessing library materials. This study concluded that usability challenges may have an impact on users' overall satisfaction with KOHA OPAC and information retrieval effectiveness. In order to enhance user experience and boost the effectiveness of information retrieval, the study recommends improvement of KOHA OPAC usability by revamping its interface and enhancing its features.
Uji Coba Pembuatan Kue Kering Sagu Dengan Penambahan Tepung Tulang Ikan Dan Daya Terimanya
Authors: Dwiyana Parlin , Siregar Elfa 
Published: March 2023

Latar belakang : Salah satu jenis kue kering adalah Kue kering sagu yang dibuat dengan bahan dasar tepung sagu. Penelitian ini dilakukan untuk memanfaatkan limbah tulang ikan yang masih memiliki zat gizi khususnya kalsium yang cukup tinggi yang ditambahkan pada pembuatan kue kering sagu Tujuan : Mengetahui pengaruh penambahan tepung tulang ikan tongkol terhadap sifat organoleptik (warna, tekstur, aroma dan rasa), daya terima dan kalsium pada kue kering sagu. Metode : Penelitian ini bersifat eksperimental, dengan melakukan penambahan tepung tulang ikan tongkol pada kue kering sagu 0%, 10%, 15% dan 20%. Penelitian ini menggunakan uji Analysis of variance dilanjutkan menggunakan uji Duncan bila p-Value 0,005. Hasil : Ada pengaruh penambahan tepung tulang ikan tongkol terhadap mutu hedonik aspek warna, aroma, rasa dan tingkat kesukaan kue kering sagu, tidak berpengaruh terhadap mutu hedonik aspek tekstur kue kering sagu. Kue kering sagu terpilih yaitu T2 (10% tepung tulang ikan tongkol) dengan nilai energi total yaitu 368 kkal, protein 10 gram, karbohidrat 68 gram, lemak total 6 gram dan kalsium sebesar 0.1 gram dengan menggunakan metode AAS. Kesimpulan : Penambahan tepung tulang ikan tongkol berpengaruh terhadap aspek warna, aroma, rasa dan tingkat kesukaan secara keseluruhan. Penambahan tepung tulang ikan tongkol tidak berpengaruh terhadap aspek tekstur kue kering sagu. Aktivitas uji kalsium sebesar 0.1 gram dalam 100 gram bahan. Saran: analisis kelayakan usaha pembuatan kue kering sagu dengan penambahan tepung tulang ikan 10% dan dilakukan diuji daya terima untuk snack pasien ginjal.
Hubungan Asupan Energi Dan Zat Gizi Makro Dengan Keberhasilan Pemberian Asi Eksklusif di Wilayah Kerja Puskesmas Kelurahan Utan Panjang Jakarta Pusat
Authors: Salwa Inaka , Prikhatina Ratih Agustin 
Published: March 2023

ASI atau Air Susu Ibu adalah cairan biologis kompleks yang mengandung semua zat gizi untuk pertumbuhan fisik bayi. Pemberian ASI secara eksklusif adalah saat bayi hanya diberi ASI saja, tanpa tambahan cairan lain seperti susu formula, jeruk, madu, air teh, air putih dan juga tanpa tambahan makanan padat seperti pisang, pepaya, bubur susu, biskuit, bubur nasi ataupun tim mulai lahir sampai usia 6 bulan. Tujuan dari penelitian ini adalah untuk mengetahui hubungan asupan energi dan zat gizi makro (protein, lemak, karbohidrat) di Wilayah Kerja Puskesmas Kelurahan Utan Panjang Jakarta Pusat. Penelitian ini menggunakan pendekatan kuantitatif dengan desain potong lintang (cross sectional) dimana variabel independen dan variabel dependen diukur secara bersamaan, dengan responden ibu yang memiliki bayi usia 6-12 bulan sebanyak 48 orang. Penelitian dilakukan pada tanggal 31 Juli – 8 Agustus 2019. Hasil penelitian didapatkan bahwa adanya hubungan yang bermakna antara asupan energi (p-value = 0,028), asupan protein (p-value = 0,020), asupan lemak (p-value = 0,033), asupan karbohidrat (p-value = 0,038), dukungan suami/keluarga (p-value = 0,001) dengan keberhasilan pemberian ASI Eksklusif. Disarankan bagi masyarakat agar dapat meningkatkan cakupan pemberian ASI eksklusif dengan memotivasi ibu untuk menerapkan pengetahuan yang dimiliki tentang ASI eksklusif dalam bentuk perilaku nyata yaitu memberikan ASI secara eksklusif kepada bayinya.
Sosialisasi Literasi Online Tentang Metaverse Indonesia di SMA Angkasa I
Authors: Narji Mohammad , Sutabri Tata , Zakaria M. Amin , Widodo Yohanes Bowo , Agustino Rano , Setiadi Dedi , Widyahastuti Febrianti 
Published: March 2023

Metaverse akan menjadi bentuk dari evolusi berikutnya dari internet, yang akan memicu evolusi dari kapitalisme. Metaverse akan membuka berbagai peluang baru untuk menghasikan uang, serta mengubah cara manusia dalam bersosialisasi, bekerja dan menjalankan bisnis.profile SMA Angkasa 1 berbasis MetaverseÂ adalahÂ media internet Â yangÂ dapat membantu suatu sekolah untuk memperkenalkan identitas serta kelebihan yang dimiliki pada sekolah yang bersangkutanÂ kepadaÂ masyarakat luas melalui dunia metaverse. Dengan memanfaatkan kemajuan dan perkembangan metaverse pada profile SMA Angkasa 1dengan penampilanÂ Â menarikÂ danÂ sesuaiÂ dengan trend Â yang ada.Â Â Maka dari itu profile SMA Angkasa 1 harus dapat mewakili serta mempresentasikan identitas tentang sekolah SMA Angkasa 1, sebabÂ era sekarang iniÂ adalahÂ eraÂ metaverse. Peneliti bermaksudÂ mempromosikan profile SMA Angkasa 1 pada aplikasi berbasis metaverse. SelainÂ menarik perhatian, profile SMA Angkasa 1 dalam bentuk mediaÂ metaverse lebihÂ praktis.Â Â Seiring berkembangnya aktivitas belajar mengajar pada Sekolah Menengah Atas (SMA) Angkasa 1, maka sekolah akan memanfaatkan teknologi metaverse Â agar lebih cepat lebih mudah dalam mengakses kemampuan belajar bagi para siswa/i. Â Metaverse adalah sebagai tempat sumber informasi dalam internet, supaya sebuah informasi dapat terbentuk dalam suatu database, maka diperlukan sebuah Augmented Reality, Virtual Reality& Video yang dinamis.Kini, berbagai negara di dunia sudah mulai mengembangkan metaverse. Sebagai negara yang terbuka akan globalisasi Indonesia akan menghadapi transformasi digital ini. Penting bagi Indonesia dalam mempersiapkan diri menghadapi perkembangan teknologi metaverse. Tujuan dari penulisan ini untuk mempromosikan tentang sosialisasi literasi online tentang metaverseÂ di SMA Angkasa 1.
Pendidikan Kesehatan Potensi Teh Hijau (Camellia Sinesis L.) Gambung Pada Mahasiswa Teknologi Laboratorium Medis
Authors: Novilla Arina , Khairinisa Gina , Davidson Dwi 
Published: March 2023

Tumbuhan telah sering digunakan sebagai alternatif dalam pengembangkan agen obat anti inflamasi yang baru dengan efek samping yang sedikit. Teh hijau merupakan salah satu jenis tanaman yangg sering dikonsumsi masyarakat karena cita rasanya. Akan tetapi, masih banyak masyarakat yang belum mengetahui manfaat kesehatan dari teh hijau. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukas terkait manfaat kesehatan teh. Kegiatan dilakukan dalam bentuk penyuluhan secara daring.Â Materi yang diberikan meliputi bahasan tentang teh hijau dan manfaatnya untuk kesehatan, mekanisme antiinflamasi dan eksperimen ilmiah yang membuktikan khasiat teh termasuk hasil penelitian para narasumber yang sudah dilakukan dan yang akan dilakukan. Selanjutnya, acara dilanjutkan dengan diskusi dan tanya jawab.Â Kegiatan webinar ini diakhiri dengan melakukan post test dan pengisian kuisioner kepuasan. Hasil menunjukkan terjadi peningkatan pengetahuan pada sebagian besar peserta (77%) setelah pemberian materi. Terdapat beberapa peserta yang tidak mengalami peningkatan (14%) dan justru mengalami penurunan (9%). Webinar yang dilaksanakan berhasil meningkatkan Â pengetahuan para mahasiswa tentang teh hijau, dan diharapkan memotivasi mahasiswa untuk lebih sering mengkonsumsi teh hijau.
Persepsi Dosen Terhadap Program MBKM Pada Institut Transportasi Dan Logistik Trisakti
Authors: Sitorus Marthaleina Ruminda , Indriyati Indriyati , Keke Yulianti , Saribanon Euis , Sari Mustika 
Published: March 2023

Proses pembelajaran dalam Kampus Merdeka merupakan salah satu perwujudan pembelajaran yang berpusat pada mahasiswa (student centered learning) yang sangat esensial. Pembelajaran dalam Kampus Merdeka memberikan tantangan dan kesempatan untuk pengembangan inovasi dan kreativitas serta mengembangkan kemandirian dalam mencari dan menemukan pengetahuan melalui kenyataan dan dinamika lapangan. Melalui program Merdeka Belajar yang dirancang dan diimplementasikan dengan baik, makaÂ hard skillÂ danÂ soft skillsÂ mahasiswa akan terbentuk dengan kuat. Kegiatan MBKM menjadi kebijakan Pemerintah sangat diperlukan didalam menghasilkanÂ outputÂ yang sesuai dengan harapan masyarakat dan dunia industri.Â Latar belakang penelitian ini adalahÂ bagaimanaÂ kesiapan dosen sebagai pendamping kegiatan MBKMÂ danÂ bertujuanÂ untukÂ mengetahuibagaimanaÂ persepsi dosenÂ pada Fakultas Manajemen dan Bisnis Institut Trasnportasi dan Logistik Trisakti (ITL Trisakti) tentang kebijakan program MBKM. Metode penelitian yang digunakan statistik deskriptif dengan melakukan survey responden terhadap para dosen yang berjumlah 92 orang. Data dikumpulkan melalui pengisian kuesioner pada link Spada Dikti yang telah dibagikan. Hasil penelitian menunjukkan bahwa dosen memperoleh informasi MBKM dari berbagai sumber sehingga memiliki pengetahuan tentang MBKMÂ menjadi tidak utuh,Â karena belum semua dosen terlibat dalam MBKM,Â baikÂ sebagai pendamping, maupunÂ yangÂ terlibat pada kegiatan seperti KKNÂ tematik,Â magang,Â praktekÂ kerjaÂ nyata, danÂ pengabdianÂ masyarakatÂ bersamaÂ mahasiswa.Â Penelitian ini menyimpulkan bahwa dosenÂ pada Fakultas Manajemen dan BisnisÂ ITL TrisaktiÂ mendukung pelaksanaan MBKM dan akan selalu meningkatkan kompetensinya agar menjadiÂ pendampingÂ yang baikÂ bagiÂ mahasiswa.