bluuebunny/crossref_metadata_2025_split huggingface dataset:
BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death
Authors: Ko Huey-Jiun , Chiou Shean-Jaw , Tsai Cheng-Yu , Loh Joon-Khim , Lin Xin-Yi , Tran Thu-Ha , Hou Chia-Chung , Cheng Tai-Shan , Lai Jin-Mei , Chang Peter Mu-Hsin , Wang Feng-Sheng , Su Chun-Li , Huang Chi-Ying F. , Hong Yi-Ren 
Published: December 2022

Abstract
Background
Despite advances in treatment, patients with refractory colorectal cancer (CRC) still have poor long-term survival, so there is a need for more effective therapeutic options.

Methods
To evaluate the HDAC8 inhibition efficacy as a CRC treatment, we examined the effects of various HDAC8 inhibitors (HDAC8i), including BMX (NBM-T-L-BMX-OS01) in combination with temozolomide (TMZ) or other standard CRC drugs on p53 mutated HT29 cells, as well as wild-type p53 HCT116 and RKO cells.

Results
We showed that HDAC8i with TMZ cotreatment resulted in HT29 arrest in the S and G2/M phase, whereas HCT116 and RKO arrest in the G0/G1 phase was accompanied by high sub-G1. Subsequently, this combination approach upregulated p53-mediated MGMT inhibition, leading to apoptosis. Furthermore, we observed the cotreatment also enabled triggering of cell senescence and decreased expression of stem cell biomarkers. Mechanistically, we found down-expression levels of β-catenin, cyclin D1 and c-Myc via GSK3β/β-catenin signaling. Intriguingly, autophagy also contributes to cell death under the opposite status of β-catenin/p62 axis, suggesting that there exists a negative feedback regulation between Wnt/β-catenin and autophagy. Consistently, the Gene Set Enrichment Analysis (GSEA) indicated both apoptotic and autophagy biomarkers in HT29 and RKO were upregulated after treating with BMX.

Conclusions
BMX may act as a HDAC8 eraser and in combination with reframed-TMZ generates a remarkable synergic effect, providing a novel therapeutic target for various CRCs.
Biology-inspired data-driven quality control for scientific discovery in single-cell transcriptomics
Authors: Subramanian Ayshwarya , Alperovich Mikhail , Yang Yiming , Li Bo 
Published: December 2022

AbstractBackgroundQuality control (QC) of cells, a critical first step in single-cell RNA sequencing data analysis, has largely relied on arbitrarily fixed data-agnostic thresholds applied to QC metrics such as gene complexity and fraction of reads mapping to mitochondrial genes. The few existing data-driven approaches perform QC at the level of samples or studies without accounting for biological variation.ResultsWe first demonstrate that QC metrics vary with both tissue and cell types across technologies, study conditions, and species. We then propose data-driven QC (ddqc), an unsupervised adaptive QC framework to perform flexible and data-driven QC at the level of cell types while retaining critical biological insights and improved power for downstream analysis.ddqcapplies an adaptive threshold based on the median absolute deviation on four QC metrics (gene and UMI complexity, fraction of reads mapping to mitochondrial and ribosomal genes).ddqcretains over a third more cells when compared to conventional data-agnostic QC filters. Finally, we show thatddqcrecovers biologically meaningful trends in gradation of gene complexity among cell types that can help answer questions of biological interest such as which cell types express the least and most number of transcripts overall, and ribosomal transcripts specifically.Conclusionsddqc retains cell types such as metabolically active parenchymal cells and specialized cells such as neutrophils which are often lost by conventional QC. Taken together, our work proposes a revised paradigm to quality filtering best practices—iterative QC, providing a data-driven QC framework compatible with observed biological diversity.
Clustering Deviation Index (CDI): a robust and accurate internal measure for evaluating scRNA-seq data clustering
Authors: Fang Jiyuan , Chan Cliburn , Owzar Kouros , Wang Liuyang , Qin Diyuan , Li Qi-Jing , Xie Jichun 
Published: December 2022

AbstractMost single-cell RNA sequencing (scRNA-seq) analyses begin with cell clustering; thus, the clustering accuracy considerably impacts the validity of downstream analyses. In contrast with the abundance of clustering methods, the tools to assess the clustering accuracy are limited. We propose a new Clustering Deviation Index (CDI) that measures the deviation of any clustering label set from the observed single-cell data. We conduct in silico and experimental scRNA-seq studies to show that CDI can select the optimal clustering label set. As a result, CDI also informs the optimal tuning parameters for any given clustering method and the correct number of cluster components.
MRI findings prior to return to play as predictors of reinjury in professional athletes: a novel decision-making tool
Authors: Isern-Kebschull Jaime , Pedret Carles , Mechó Sandra , Pruna Ricard , Alomar Xavier , Yanguas Xavier , Valle Xavier , Kassarjian Ara , Martínez Javier , Tomas Xavier , Rodas Gil 
Published: December 2022

Abstract
Background
Because MRI has shown great accuracy in assessing acute muscle injuries, identification of risk factors for reinjury before return to play (RTP) in professional athletes during the healing process could be very relevant. We assessed the value of MRI findings prior to RTP as predictors of reinjury.

Methods
Retrospective observational study of 59 professional athletes, mean age 26 years, with first-time acute muscle injury and successful rehabilitation ready to RTP. They underwent MRI within 6 days of the injury and within 7 days prior to RTP. The primary outcome was reinjury. Risk of reinjury was assessed using radiological signs in control MRI scans before RTP. The risk was classified as low, medium or high when none, one or two radiological signs were observed, respectively.

Results
Reinjury occurred in 9 participants, with a rate of 15.2%. None of the baseline MRI-related variables was significantly associated with reinjury. In the control MRI scan performed within 7 days prior to RTP, three independent findings were significantly associated with reinjury. These included transversal and/or mixed connective tissue gap (p = 0.002), intermuscular oedema (p = 0.015) and callus gap (p = 0.046). In the predictive model of the risk of reinjury, the presence of two of these radiological signs, together with interstitial feathery oedema, was associated with a high risk of recurrence (OR 29.58, 95% CI 3.86–226.64; p = 0.001).

Conclusions
In professional athletes with acute muscle injuries of the lower limbs successfully rehabilitated, some radiological signs on MRI performed shortly before RTP were associated with a high risk of reinjury.
A prediction nomogram for suboptimal debulking surgery in patients with serous ovarian carcinoma based on MRI T1 dual-echo imaging and diffusion-weighted imaging
Authors: Liu Li , Wang Jie , Wu Yan , Chen Qiao , Zhou Linyi , Linghu Hua , Li Yongmei 
Published: December 2022

Abstract
Background
Serous ovarian carcinoma (SOC) has the highest morbidity and mortality among ovarian carcinoma. Accurate identification of the probability of suboptimal debulking surgery (SDS) is critical. This study aimed to develop a preoperative prediction nomogram of SDS for patients with SOC.

Methods
A prediction model was established including 205 patients of SOC from institution A, and 45 patients from institution B were enrolled for external validation. Multivariate logistic regression was used to screen independent predictors and establish a nomogram to predict the occurrence of SDS.

Results
Multivariate logistic regression demonstrated that the CA-125 level (odds ratio [OR] 8.260, 95% confidence interval [CI] 2.003–43.372), relationship between the sigmoid colon/rectum and ovarian mass (OR 28.701, 95% CI 4.561–286.070), diaphragmatic metastasis (OR 12.369, 95% CI 1.675–274.063), and FIGO stage (OR 32.990, 95% CI 6.623–274.509) were independent predictors for SDS. The area under the curve, concordance index, and 95% CI of the nomogram constructed from the above four factors were 0.951, 0.934, and 0.919–0.982, respectively. The model showed a good fit by the Hosmer–Lemeshow test (training set, p = 0.2475; internal validation set, p = 0.2355; external validation set, p = 0.2707). The external validation proved the reliability of the prediction nomogram. The calibration curve was close to the ideal diagonal line. The decision curve analysis demonstrated a significantly better net benefit. The clinical impact curve indicated good effectiveness in clinical application.

Conclusion
A prediction nomogram for SDS in patients with SOC provides gynecologists with an accurate and effective tool for appropriate management.
Smallholder dairy producers’ participation in dairy marketing in Southern Omo Zone, Ethiopia
Authors: Kena Doyo , Golicha Dida , Jemal Ebrahim , Kanu Boru , Gayo Galma 
Published: December 2022

AbstractDairy market development has been hampered by multi-faceted problems such as low adoption of improved technologies, absence of clear policy support for the sector, marketing problems, and other institutional factors. This study was aimed at analysing determinants of smallholder dairy producers’ participation decisions in dairy marketing and the intensity of participation in dairy marketing. It is also aimed at identifying the existing major constraints on dairy marketing in the study area. A total of 150 random sample households were chosen, and data were analysed using descriptive and econometric methods. A Heckman two-step selection model was used to analyse the determinants of dairy market participation decisions and levels of participation. The results indicated lower participation in dairy marketing (38.67%), despite the huge potential of livestock production in the area. Dairy producers’ market participation decisions were found to be significantly affected by the education status of the household head, access to market information, distance to the nearest market, number of lactating cows, and membership in a cooperative group, while the age of the household head, education status, land holding, and number of lactating cows significantly affected the dairy product sale volume. The findings imply that market information delivery systems, market infrastructures, and vocational education should be strengthened by the government and development partners.
Inclusion relations for some classes of analytic functions involving Pascal distribution series
Authors: Lashin Abdel Moneim Y. , Badghaish Abeer O. , Algethami Badriah Maeed 
Published: December 2022

AbstractIn this article, we introduce and discuss some new subclasses of functions that are analytic in the open unit disc and involve the Pascal distribution series. Moreover, inclusion relations and integral preserving properties of these subclasses are determined.
Fixed points of completely positive maps and their dual maps
Authors: Zhang Haiyan , Dou Yanni 
Published: December 2022

AbstractLet $\mathcal {A} \subset{\mathcal {B}}(\mathcal {H})$
A
⊂
B
(
H
)
be a row contraction and $\Phi _{\mathcal {A}}$

Φ
A

determined by $\mathcal {A}$
A
be a completely positive map on ${\mathcal {B}}(\mathcal {H})$
B
(
H
)
. In this paper, we mainly consider fixed points of $\Phi _{\mathcal {A}}$

Φ
A

and its dual map $\Phi _{\mathcal {A}}^{\dagger}$

Φ
A
†

. It is given that $\Phi _{\mathcal {A}}(X)\leq X $

Φ
A

(
X
)
≤
X
(or $\Phi _{\mathcal {A}}(X)\geq X $

Φ
A

(
X
)
≥
X
) implies $\Phi _{\mathcal {A}}(X)= X$

Φ
A

(
X
)
=
X
and $\Phi _{\mathcal {A}}^{\dagger}(X)= X$

Φ
A
†

(
X
)
=
X
when $X\in {\mathcal {B}}(\mathcal {H})$
X
∈
B
(
H
)
is a compact operator. Some necessary conditions of $\Phi _{\mathcal {A}}(X)= X$

Φ
A

(
X
)
=
X
and $\Phi _{\mathcal {A}}^{\dagger}(X)= X$

Φ
A
†

(
X
)
=
X
are given.
Efficacy and safety of prone position in COVID-19 patients with respiratory failure: a systematic review and meta-analysis
Authors: Lee Hyeon-Jeong , Kim Junghyun , Choi Miyoung , Choi Won-Il , Joh Joonsung , Park Jungeun , Kim Joohae 
Published: December 2022

AbstractBackgroundProne position has already been demonstrated to improve survival in non-COVID acute respiratory distress syndrome and has been widely performed in COVID-19 patients with respiratory failure, both in non-intubated and intubated patients. However, the beneficial effect of the prone position in COVID-19 pneumonia still remains controversial. Therefore, we aimed to evaluate the effectiveness and safety of the prone position compared with the non-prone in non-intubated and intubated COVID-19 patients, respectively.MethodsWe searched the MEDLINE, EMBASE, and Cochrane databases, as well as one Korean domestic database, on July 9, 2021, and updated the search 9 times to September 14, 2022. Studies that compared prone and non-prone positions in patients with COVID-19 were eligible for inclusion. The primary outcomes were mortality, need for intubation, and adverse events.ResultsOf the 1259 records identified, 9 randomized controlled trials (RCTs) and 23 nonrandomized studies (NRSs) were eligible. In the non-intubated patients, the prone position reduced the intubation rate compared with the non-prone position in 6 RCTs (n = 2156, RR 0.81,P = 0.0002) and in 18 NRSs (n = 3374, RR 0.65,P = 0.002). In the subgroup analysis according to the oxygen delivery method, the results were constant only in the HFNC or NIV subgroup. For mortality, RCTs reported no difference between prone and non-prone groups, but in NRSs, the prone position had a significant advantage in mortality [18 NRSs,n = 3361, relative risk (RR) 0.56,P < 0.00001] regardless of the oxygen delivery methods shown in the subgroup analysis. There was no RCT for intubated patients, and mortality did not differ between the prone and non-prone groups in NRSs. Adverse events reported in both the non-intubated and intubated groups were mild and similar between the prone and non-intubated groups.ConclusionFor non-intubated patients with COVID-19, prone positioning reduced the risk of intubation, particularly in patients requiring a high-flow oxygen system. However, the survival benefit was unclear between the prone and non-prone groups. There was insufficient evidence to support the beneficial effects of prone positioning in intubated patients.Trial registrationThis study was registered in the Prospective Register of Systematic Reviews on February 16, 2022 (Registration No.:CRD42022311150).
A bibliometric analysis of chronic subdural hematoma since the twenty-first century
Authors: Chen Rundong , Wei Yanpeng , Xu Xiaolong , Zhang Renkun , Tan Yuhao , Zhang Guanghao , Yin Hongwei , Dai Dongwei , Li Qiang , Zhao Rui , Huang Qinghai , Xu Yi , Yang Pengfei , Liu Jianmin , Zuo Qiao 
Published: December 2022

Abstract
Background
Chronic subdural hematoma (CSDH) is a common disease that forms between the dura and arachnoid membranes of the brain. With the development of medications and surgery, significant progress has been made in the diagnosis and treatment of CSDH. However, there is no comprehensive analysis available on CSDH-related studies published in the literature. This study aimed to collect and analyze CSDH-related studies published since the twenty-first century using bibliometric analysis and to summarize the current status of research in this field for the sake of providing systematic data for further study of CSDH.

Methods
CSDH-related studies were searched in the Web of Science Core Collection (WoSCC) database using the Medical Subject Heading (MeSH) term ‘chronic subdural hematoma’. Data analysis and visualization were performed by R and CiteSpace software.

Results
This study retrieved 1424 CSDH-related articles published since the beginning of the twenty-first century. There was a general increase in both the number of published articles and the mean number of citations. The authors, institutions and journals that contributed the most to the field of CSDH were Jianning Zhang, Tianjin Medical University, and world neurosurgery, respectively. The reference co-citation network identified 13 clusters with significant modularity Q scores and silhouette scores (Q = 0.7124, S = 0.8536). The major research categories were (1) evolution of the therapeutic method and (2) the etiology and pathology of CSDH. Keyword analysis revealed that ‘middle meningeal artery embolization’ was the latest burst keyword.

Conclusions
This study identified the most influential countries, authors, institutions and journals contributing to CSDH research and discussed the hotspots and the latest subjects of CSDH research.
Management of classical Hodgkin lymphoma: a look at up to date evidence and current treatment approaches
Authors: Hanel Walter , Herrera Alex F. , Epperla Narendranath 
Published: December 2022

AbstractThe treatment landscape of classical Hodgkin lymphoma (cHL) has undergone significant changes over the past 20 years. Gradual improvements have been made in the management of cHL patients, particularly in prolonging the survival rate for those in the relapsed setting. Most of these improvements came with the addition of brentuximab vedotin and PD1 blockade (nivolumab and pembrolizumab) into the current cHL treatment algorithms. On the other hand, the treatment approach to cHL has become more complex than ever before, with multiple ways to add and sequence therapies to achieve long-term remission. In this review, we will discuss the most up-to-date evidence on the management of cHL patients with the inclusion of ongoing clinical trials in cHL. We will provide a general overview of the current therapeutic landscape of cHL in light of these most recent data. We conclude with our perspective on how the approach to cHL treatment may evolve in the future.
CPR in correctional facilities: a missed opportunity?
Authors: Sampson Christopher Scott , Stilley Julie A. W. , Kendrick Elizabeth , Riel Kayla 
Published: December 2022

AbstractIn the incarcerated population, the largest ethnic and racial group is Black people. Heart disease is known as the leading causes of death in the United States which can lead to cardiac arrest. Layperson cardiopulmonary resuscitation (CPR) has been shown to provide a benefit and increase likelihood of return of spontaneous circulation (ROSC). Recent research shows that in witnessed out of hospital cardiac arrests, the likelihood of receiving bystander CPR was found to be less among Black or Hispanic people when compared to White persons. One neglected area for layperson CPR training are these correctional facilities. This population is known to have higher rates of diabetes, high blood pressure and coronary artery disease, all of which contribute to an increased risk of acute coronary syndrome.A search was performed of the NEMSIS database. When comparing witnessed cardiac arrest, incidents without bystander interventions occurred more frequently than expected if the arrest was witnessed by a family member or other lay person. These interventions included bystander CPR or AED placement with or without defibrillation.The data presented shows that there is an unmet need of additional lay person CPR training in correctional facilities which could be implemented for little cost.
Psychological well-being among Saudi adults during the context of COVID-19 lockdown: a psychometric analysis of the 12-item General Health Questionnaire
Authors: Hamad Eradah O. 
Published: December 2022

AbstractBackgroundMost communities' mental health and perceptions of psychological well-being are known to be profoundly disrupted by large-scale pandemics. Despite the wide range of available screening measures, few reliable and valid screening measures exist for assessing overall psychological well-being in nonclinical populations during a health emergency situation such as the COVID-19 outbreak.ObjectiveThis study aims to conduct a psychometric analysis of Goldberg’s 12-item General Health Questionnaire (GHQ-12) to validate its use among a sample of Saudi adults during the COVID-19 lockdown using reliability and factor analyses.MethodsA total of 473 individuals (aged 18 years and over) were recruited from the general Saudi population living in the Makkah (Western) Province of Saudi Arabia to complete the virtual format of the Arabic GHQ-12 (Ar-GHQ-12). In addition to a descriptive statistics measurement and reliability analysis, confirmatory factor analyses (CFA) were performed to examine the unidimensionality and validity of the Ar-GHQ-12.ResultsIn line with previous works from several cultures, the Ar-GHQ-12 with two-factor solution considered to be the best-fitting model because it fits the data better than the one-factor (unidimensional) model did, and adequate reliability indices were achieved for each factor (.83 for factor 1 and .65 for factor 2).DiscussionThe Ar-GHQ-12 was determined to be suitable for assessing the overall psychological well-being of the general population in Saudi Arabia in emergency contexts and may be applied among Saudis and other Arabic-speaking populations in research and primary care settings.
Who perceives more value of teacher feedback? Exploring the roles of college students’ possible second language selves and language learning strategies
Authors: Zhan Ying , Lee John Chi-Kin , Wan Zhi Hong 
Published: December 2022

AbstractStudents can only benefit from teacher feedback if they recognise its value for learning. However, there is still a lack of research to investigate the factors influencing students’ perceptions of the value of teacher feedback in the context of learning English as a foreign language. This study investigated the impacts of two significant individual factors (i.e. possible second language (L2) selves and language learning strategies) of 687 college English learners on their perceived value of teacher feedback (i.e. grades and comments) in a Chinese university. Structural equation modelling analyses indicated the following:(i) Ideal L2 self significantly and positively predicted the perceived value of grades, both directly and indirectly (mediated by self-regulation strategies).(ii) Ideal L2 self significantly and positively predicted the perceived value of teacher comments, both directly and indirectly (mediated by social strategies and self-regulation strategies).(iii) Ought-to L2 self only indirectly predicted the perceived value of grades, mediated by memory strategies.The findings highlight students’ proactive roles in the feedback process. Only if students aspire to become proficient English users and frequently use deep language learning strategies, they will perceive more value of teacher feedback and take up it for better learning.