bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Intra- and Interthematic Functions Collide: Conflation in Robert Schumann’s Orchestral Sonata Forms
Authors: Poon Matthew 
Published: September 2023

Abstract
This article analyzes formal fusion in the first movements of Schumann’s Symphonies Nos. 1 and 2 and the finale of his Overture, Scherzo, and Finale. Within these pieces, fusion results from what Julian Horton (2015) calls “conflation”—that is, a process in which previously distinct formal levels collapse into each other—resulting in two new categories of sonata expositions I term bipartite and undivided. These categories help explain some of the unique features of Schumann’s orchestral music and provide new tools toward understanding nineteenth-century form.
Prescribing the dialysis dose and treatment frequency in home haemodialysis
Authors: Casino Francesco Gaetano , Roblero Maria Fernanda Slon , González-Sanchidrian Silvia , Dominguez Sandra Gallego , Ferris Ignacio Lorenzo , Luyckx Valerie A , Liakopoulos Vassilios , Mitra Sandip , Lorenzo Javier Deira , Basile Carlo 
Published: September 2023

ABSTRACT

Background
There is growing interest in home haemodialysis (HHD) performed with low-flow dialysate devices and variable treatment schedules. The target standard Kt/V (stdKt/V) should be 2.3 volumes/week, according to KDOQI guidelines (2015). The current formula for stdKt/V does not help prescribe the dialysis dose (eKt/V) and treatment frequency (TF). The aim of this study was to obtain a formula for stdKt/V that is able to define the minimum required values of eKt/V and TF to achieve the targeted stdKtV.

Methods
Thirty-eight prevalent patients on HHD were enrolled. A total of 231 clinical datasets were available for urea modelling using the Solute-Solver software (SS), recommended by KDOQI guidelines. A new formula (stdKt/V = a + b × Kru + c × eKt/V) was obtained from multivariable regression analysis of stdKt/V vs eKt/V and residual kidney urea clearance (Kru). The values of coefficients a, b and c depend on the treatment schedules and the day of the week of blood sampling for the kinetic study (labdayofwk) and then vary for each of their foreseen 62 combinations. For practical purposes, we used only seven combinations, assuming Monday as a labdayofwk for each of the most common schedules of the 7 days of the week.

Results
The stdKt/V values obtained with SS were compared with the paired ones obtained with the formula. The mean ± standard deviation stdKt/V values obtained with SS and the formula were 3.043 ± 0.530 and 2.990 ± 0.553, respectively, with 95% confidence interval +0.15 to –0.26. A ‘prescription graph’ was built using the formula to draw lines expressing the relationship between Kru and required eKt/V for each TF. Using this graph, TF could have been reduced from the delivered 5.8 ± 0.8 to 4.8 ± 0.8 weekly sessions.

Conclusions
The new formula for stdKtV is reliable and can support clinicians to prescribe the dialysis dose and TF in patients undergoing HHD.
A strict vegetarian diet may be harmful: bilateral macular bleeding in vitamin B12 deficiency
Authors: Singh Jitendra , Dinkar Anju 
Published: September 2023

Abstract
A 35-year-old Indian male office worker presented with complaints of progressive weakness, fatigability, and diminished vision. The patient followed a strict vegetarian diet. Clinical examination revealed pallor. Fundoscopy revealed a bilateral macularbleed. Vitamin B12 deficiency was determined to be the cause based on the clinical and laboratory results. Three months later, he reported a near-normal vision in both eyes and a normal complete hemogram. The present clinical picture demonstrates an unusual facet of clinical feature in vitamin B12 deficiency, an event rarely encountered.
Polyarteritis nodosa in a patient with chronic hepatitis B following COVID-19 vaccination: a case report
Authors: Abuhammad Aseel , Dukmak Osama N , Asad Diya , Bakri Izzeddin A , Attawna Saed I Y 
Published: September 2023

Abstract
Different types of vasculitis have been reported after various vaccine administrations. Recently, the coronavirus disease 2019 (COVID-19) vaccine was one of the most common vaccine-induced vasculitis. Herein, we describe a 56-year-old male patient with chronic hepatitis B who presented with abdominal pain for 2 days, which was associated with vomiting and bloody diarrhea. He had a history of petechial rash for 25 days, multiple joint pain and lower limb weakness after the second dose of the COVID-19 vaccine. A skin biopsy showed medium-sized vessel vasculitis. Polyarteritis nodosa (PAN) was diagnosed depending on the American College of Rheumatology criteria. He was treated with steroids, plasmapheresis and antiviral medication with a good prognosis. In patients with a past medical history of chronic hepatitis B, the covid vaccine may be associated with an increased risk of developing a PAN, so clinicians should suspect the occurrence of this disease after COVID-19 vaccination.
A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies
Authors: Chérif Mohammad Yassine , Raftakis Ioannis , Weynand Marjolaine , Dragan Elena , Nagant Carole , Lecomte Sophie , Badot Valérie 
Published: September 2023

Abstract
Statins competitively inhibit the activity of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), which is a key enzyme in cholesterol synthesis. These are effective drugs for the management of cardiovascular disease and are generally well tolerated but several side effects have been reported. Muscular adverse symptoms are various and, rarely, statin exposure may lead to authentic immune-mediated necrotizing myopathy (IMNM), namely anti-HMGCR myopathy. However, cases of IMNM associated with cancer have been described. We discuss herein a case of IMNM in a patient with breast cancer previously exposed to statins and with the presence of anti-Th/To antibodies without clinical correlation.
Plant Organellar MSH1 Is a Displacement Loop–Specific Endonuclease
Authors: Peñafiel-Ayala Alejandro , Peralta-Castro Antolin , Mora-Garduño Josue , García-Medel Paola , Zambrano-Pereira Angie G , Díaz-Quezada Corina , Abraham-Juárez María Jazmín , Benítez-Cardoza Claudia G , Sloan Daniel B , Brieba Luis G 
Published: September 2023

Abstract
MutS HOMOLOG 1 (MSH1) is an organellar-targeted protein that obstructs ectopic recombination and the accumulation of mutations in plant organellar genomes. MSH1 also modulates the epigenetic status of nuclear DNA, and its absence induces a variety of phenotypic responses. MSH1 is a member of the MutS family of DNA mismatch repair proteins but harbors an additional GIY-YIG nuclease domain that distinguishes it from the rest of this family. How MSH1 hampers recombination and promotes fidelity in organellar DNA inheritance is unknown. Here, we elucidate its enzymatic activities by recombinantly expressing and purifying full-length MSH1 from Arabidopsis thaliana (AtMSH1). AtMSH1 is a metalloenzyme that shows a strong binding affinity for displacement loops (D-loops). The DNA-binding abilities of AtMSH1 reside in its MutS domain and not in its GIY-YIG domain, which is the ancillary nickase of AtMSH1. In the presence of divalent metal ions, AtMSH1 selectively executes multiple incisions at D-loops, but not other DNA structures including Holliday junctions or dsDNA, regardless of the presence or absence of mismatches. The selectivity of AtMSH1 to dismantle D-loops supports the role of this enzyme in preventing recombination between short repeats. Our results suggest that plant organelles have evolved novel DNA repair routes centered around the anti-recombinogenic activity of MSH1.
To err is human; to be perfect is AI: embracing mistakes as a catalyst for human formation development
Authors: Deguma Melona C 
Published: September 2023

Abstract
In a culture overwhelmed by the quest for perfection, thereby committing acts like intellectual dishonesty, erring is left to be a valuable human experience. Recent articles in the Oxford Journal of Public Health explore the impact of artificial intelligence (AI) technology on human relationships in different settings. It is crucial to acknowledge the potential benefits of AI while also being mindful of its possible misuse. As AI technology becomes more integrated into our daily lives, pursuing perfection propels its advancement. However, using AI technology to pursue perfection may adversely affect people’s mental health. In this paper, I argue that pursuing perfection can harm one’s well-being. Instead, it is crucial to acknowledge and embrace one’s mistakes to foster personal growth and development.
Atopic manifestations of inborn errors of immunity
Authors: Sams Laura , Wijetilleka Sonali , Ponsford Mark , Gennery Andrew , Jolles Stephen 
Published: September 2023

Purpose of review
Allergy and atopic features are now well recognized manifestations of many inborn errors of immunity (IEI), and indeed may be the hallmark in some, such as DOCK8 deficiency. In this review, we describe the current IEI associated with atopy, using a comprehensive literature search and updates from the IUIS highlighting clinical clues for underlying IEI such as very early onset of atopic disease or treatment resistance to enable early and accurate genetic diagnosis.

Recent findings
We focus on recently described genes, their categories of pathogenic mechanisms and the expanding range of potential therapies.

Summary
We highlight in this review that patients with very early onset or treatment resistant atopic disorders should be investigated for an IEI, as targeted and effective therapies exist. Early and accurate genetic diagnosis is crucial in this cohort to reduce the burden of disease and mortality.
Neighborhood Deprivation and Neural Tube Defects
Authors: Pruitt Evans Shannon , Ailes Elizabeth C. , Kramer Michael R. , Shumate Charles J. , Reefhuis Jennita , Insaf Tabassum Z. , Yazdy Mahsa M. , Carmichael Suzan L. , Romitti Paul A. , Feldkamp Marcia L. , Neo Dayna T. , Nembhard Wendy N. , Shaw Gary M. , Palmi Elizabeth , Gilboa Suzanne M. ,   National Birth Defects Prevention Study
Published: September 2023

Background:
Individual measures of socioeconomic status (SES) have been associated with an increased risk of neural tube defects (NTDs); however, the association between neighborhood SES and NTD risk is unknown. Using data from the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we investigated the association between measures of census tract SES and NTD risk.

Methods:
The study population included 10,028 controls and 1829 NTD cases. We linked maternal addresses to census tract SES measures and used these measures to calculate the neighborhood deprivation index. We used generalized estimating equations to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) estimating the impact of quartiles of census tract deprivation on NTDs adjusting for maternal race–ethnicity, maternal education, and maternal age at delivery.

Results:
Quartiles of higher neighborhood deprivation were associated with NTDs when compared with the least deprived quartile (Q2: aOR = 1.2; 95% CI = 1.0, 1.4; Q3: aOR = 1.3, 95% CI = 1.1, 1.5; Q4 (highest): aOR = 1.2; 95% CI = 1.0, 1.4). Results for spina bifida were similar; however, estimates for anencephaly and encephalocele were attenuated. Associations differed by maternal race–ethnicity.

Conclusions:
Our findings suggest that residing in a census tract with more socioeconomic deprivation is associated with an increased risk for NTDs, specifically spina bifida.
The Relationships Between Blood Pb Levels and Blood Pressure Among Lead-Exposed Workers in China: A Repeated-Measure Study
Authors: Han Zhiyuan , Gong Shiyang , Tu Yuting , Lang Chunyan , Tang Jiachun , Wang Tuanwei , Xia Zhao-lin 
Published: September 2023

Objectives
To explore the differences in the increase of systolic blood pressure (SBP) and diastolic blood pressure (DBP) in 3 consecutive years among lead (Pb) workers.

Methods
Four hundred forty-eight Pb workers were enrolled in this repeated-measure study. Blood Pb, SBP, and DBP were measured in 2015 to 2017. Repeated measure of analysis of variance was used to compare the differences in the increase of SBP and DBP.

Results
The mean SBP values were 124.0/125.5/126.9 mm Hg, and the mean DBP values were 75.4/77.4/77.8 mm Hg from 2015 to 2017. The differences in the increase of SBP and DBP were 2.94/2.42 mm Hg during the 3-year period. The average annual increase of SBP or DBP showed an upward trend in different Pb dose groups (F = 4.904, P = 0.002; F = 3.612, P = 0.013).

Conclusions
Lead exposure caused average annual increases in SBP and DBP with 0.98 and 0.81 mm Hg, which provided basic data for health surveillance.
Determining Unmet Needs Among Workers’ Compensation Stakeholders to Prevent Work Disability in the State of Vermont
Authors: Peterik Kara , Kennedy Deborah , Bentley Mary Helen , Guyette Mary , David Dent , McDonough Christine , Ulack Christopher , Wallace Scott , Huyck Karen 
Published: September 2023

Purpose
Vermont has high rates of young people receiving federal disability benefits leading to substantial gaps in the workforce. The purpose of this project was to determine the unmet needs of interested parties in the workers’ compensation (WC) process.

Methods
A type of focus group, experience groups, was used to elicit key parties’ experiences in the WC system. Facilitators used open-ended prompts to encourage discussion among participants about their experience with the WC system. Data were analyzed using thematic coding procedures to identify common motifs.

Results
Common themes emerged including challenges in navigating the WC system, lack of communication among stakeholders, and providing and receiving appropriate health care to facilitate RTW.

Conclusions
Understanding unmet needs of interested parties in the WC process allows for the creation of targeted, high-value, early intervention strategies to reduce long-term work disability.
Use of artificial intelligence to identify patients to be assessed in a breast clinic on 2-week wait: a retrospective cohort study
Authors: Rao Ahsan , Manley Lara , Smith Simon 
Published: September 2023

Background:
The number of urgent referrals from primary care to specialist one stop breast clinics continues to rise beyond the capacity of the 2-week wait service. This study aims to use artificial intelligence (AI) to identify patients with new breast symptoms requiring a biopsy to identify those who should be prioritised for urgent breast clinic assessment.

Methods:
Data were collected retrospectively for patients attending one stop triple assessment breast clinic at Broomfield hospital between 1 June and 1 October 2021. PHP machine learning software was used to run AI on the data to identify patients who had a core biopsy in clinic.

Results:
A total of 794 cases were referred to one stop breast clinic for new breast symptoms—37 male (4.6%) and 757 female (95.3%). The average age of the patients included was 43.2 years. Five hundred thirty-six patients (67.5%) presented with a breast lump, 180 (22.7%) with breast pain, 61 (7.7%) with changes to shape or skin and 13 (1.6%) with a lump identified by their general practitioner. The patients who had a biopsy were of increased age [52.8 (SD 17.9) vs. 44.1 (SD 16.8), P<0.001], and had previous mammogram [n=21, (31.8%) vs. n=148 (20.3%), P 0.03], previous benign breast disease [n=9 (13.6%) vs. n=23 (3.1%), P<0.001], and increased use of HRT [n=13 (19.7%) vs. n=53 (6.4%), P<0.001]. The sensitivity and specificity of AI with neural network algorithms were 84% and 90%, respectively.

Conclusion:
AI was very effective at predicting the presenting symptoms that are likely to result in biopsy and can therefore be used to identify patients who need to be seen urgently in breast clinic.
The Presence of an Arteria Lusoria Should Be Checked When Reporting 18F-FCH PET/CT Performed to Localize Hyperfunctioning Parathyroid Glands
Authors: Talbot Jean-Noël , Périé Sophie , Tassart Marc , Safa Jean-Baptiste , Montravers Françoise , Balogova Sona 
Published: September 2023

Abstract
Nonrecurrent inferior laryngeal nerve (NRILN) is a rare anatomical variant, which significantly increases the risk of nerve injury during neck surgery, for example, thyroidectomy or parathyroidectomy (PTX). The absence of the brachiocephalic trunk and presence of arteria lusoria (AL) are strong predictors of NRILN in the right neck. FCH PET/CT is now a recognized imaging modality in hyperparathyroidism (HPT). We report 2 patients with primary or renal HPT in whom FCH PET detected right HFPTs and low-dose noncontrast CT evidenced AL. The NRILN was thus preserved during PTX. We recommend searching for AL on FCH PET/CT (even low-dose) in HPT before PTX.
Impact of 18F-FDG PET on the Management in Patients With Recurrent Gynecologic cancer
Authors: Pak Kyoungjune , Yoon Hai-Jeon 
Published: September 2023

Purpose
Gynecological cancer is the most prevalent cancer among women worldwide. We performed a meta-analysis to assess the impact of 18F-FDG PET on the management of patients with recurrent gynecological cancers, including cervical, uterine, and ovarian cancers.

Methods
We systematically searched MEDLINE and EMBASE databases for English-language publications. All published studies on the impact of PET scans on the management of patients with recurrent gynecological cancers were reviewed. The proportion of management change (%), defined as the percentage of patients whose management changed after FDG PET to those who underwent FDG PET, was calculated. The data from each study were analyzed using MedCalc Statistical Software version 14.12.0 (MedCalc Software, Ostend, Belgium).

Results
Nineteen studies including 6191 patients were eligible for inclusion. The impact of FDG PET scan for detecting recurrence/metastasis in patients with gynecologic cancer was evaluated using management change rates, ranging from 9.4% to 60.7% with a pooled effect of 42.0% (95% confidence interval [CI], 34.5%–49.6%; I
2 = 92.9%). In the subtype analysis, FDG PET scanning resulted in changes in the management in 48.5% (95% CI, 37.8%–59.3%; I
2 = 67.8%) of cervical cancer, 34.7% (95% CI, 33.4%–36.0%; I
2 = 0%) of uterine cancer, and 40.3% (95% CI, 26.7%–54.7%; I
2 = 95.2%) of ovarian cancer cases.

Conclusions
FDG PET has a significant impact on the restaging of patients with gynecological cancer. These findings suggest that FDG PET should be performed, especially in cases of suspected recurrence/metastasis in the main gynecologic cancer types, including cervical, ovarian, and uterine cancers.
Metastatic Esophageal Adenocarcinoma Showing 68Ga-DOTATATE Uptake
Authors: Fılızoglu Nuh , Ozguven Salih 
Published: September 2023

Abstract
The role of 68Ga-DOTATATE PET/CT in the evaluation of neuroendocrine tumors is well defined. Nevertheless, 68Ga-DOTATATE uptake may be seen in some tumors other than neuroendocrine tumors as a reflection of tumor blood supply and somatostatin receptor expression. Although 68Ga-DOTATATE uptake has been described in a number of nonneuroendocrine tumors, no case of 68Ga-DOTATATE uptake in esophagus adenocarcinoma has been reported. We present the case of a 52-year-old man who had a metastatic esophageal adenocarcinoma showing 68Ga-DOTATATE uptake.
68Ga-PSMA–Avid Liver Metastases From Colon Cancer, Not Visualized on FDG PET Scan
Authors: Doroudinia Abtin , Chekuri Satyanarayana 
Published: September 2023

Abstract

18F-FDG PET/CT scan is a well-known modality to assess distant metastases and treatment response in the patients with primary colon cancer. We are presenting an interesting case of 68Ga-PSMA–avid liver metastases in a 74-year-old man with colon cancer and recently diagnosed prostate cancer. The liver metastases were positive on initial FDG PET but lost FDG avidity on subsequent posttreatment FDG PET scans. Biopsy from the PSMA-avid liver lesions confirmed metastasis from colon origin. PSMA is expressed in various forms of tumor neovasculature other than prostate cancer with potential new applications as a theranostic agent in the future.
Steroids May Be Associated With Extensive Skeletal Muscle Uptake of 18F-FDG
Authors: Kawabata Kazuna , Hosono Makoto , Mori Yukiko , Tsukamoto Suzune , Ito Shunsuke , Ando Saya , Kanagaki Mitsunori 
Published: September 2023

Purpose
The possibility of steroid administration inducing the extensive skeletal muscle uptake (ESMU) of FDG in PET scans was investigated.

Methods
From 8923 consecutive 18F-FDG PET/CT scans taken at our hospital, 23 scans (15 patients) met adult age and ESMU-positive inclusion criteria. Among the 15 patients, 13 with both ESMU-positive and -negative scans were examined for association with steroid administration.

Results
Extensive skeletal muscle uptake was associated with a history of steroid administration (χ
2 test: P = 0.001). Notably, 20 ESMU-positive scans and 11 ESMU-negative scans were significantly different, with 0 to 95 days (median, 18.5 days) and 0 to 708 days (median, 319.0 days) since the last steroid administration, respectively (Mann-Whitney U test, P = 0.003). A significant correlation was observed between mean skeletal muscle SUVmax and the number of days since the last steroid administration (Spearman rank correlation coefficient, ρ = −0.501, P = 0.004). Specifically, the degree of ESMU tended to decrease over time, after steroid administration. From multiple regression analysis, the number of days since the last steroid administration was significantly associated with mean SUVmax (P = 0.007), but the blood glucose level was not significant (P = 0.204), revealing that the number of days since the last steroid administration was an independent risk factor. Multicollinearity was low (the variance inflation factor was 1.007 for both the number of days since the last steroid administration and blood glucose levels).

Conclusions
Steroid administration within months before PET may be one cause of ESMU.
Parasedimentitalea psychrophila sp. nov., a psychrophilic bacterium isolated from deep-sea sediment
Authors: Li An-Qi , Zhang Chan , Li Deng-Hui , Qi Xiao-Qing , Meng Liang , Wu Long-Fei , Li Xue-Gong , Zhang Wei-Jia 
Published: September 2023

A novel bacterium, strain QS115T, was isolated from deep-sea sediment collected from the South China Sea at a depth of 1151 m. Phylogenetic analyses based on 16S rRNA gene sequences indicated that QS115T was most closely related to

Parasedimentitalea marina

W43T, with similarity of 98.21 %. Strain QS115T shared 82.39 % average nucleotide identity, 26.3 % digital DNA–DNA hybridization and 85.32 % average amino acid identity with

P. marina

W43T. Cells of strain QS115T were Gram-stain-negative, rod-shaped and grew optimally at 10 °C, pH 7.5 and 2 % (w/v) NaCl. The principal fatty acids were summed feature 8 (C18 : 1
ω7c/ω6c), the major respiratory quinone was ubiquinone-10 and predominant polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, glycophospholipid, phosphatidylglycerol and phosphatidylcholine. Polyphasic analyses of physiological and phenotypic characteristics and genomic studies suggested that strain QS115T represents a novel species of the genus

Parasedimentitalea

, for which the name Parasedimentitalea psychrophila sp. nov. is proposed (type strain QS115T=MCCC 1K04395T=JCM 34219T).