bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating neutrophil‐related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study
Authors: Buckley Leo F. , Dorbala Pranav , Claggett Brian L. , Libby Peter , Tang Weihong , Coresh Josef , Ballantyne Christie M. , Hoogeveen Ron C. , Yu Bing , Shah Amil M. 
Published: August 2023

AbstractAimsNeutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine.Methods and resultsNeutrophil activity‐related plasma proteins known to be affected by colchicine treatment were measured at Visit 3 (1993–1995) and Visit 5 (2011–2013) of the ARIC cohort study. A protein‐based neutrophil activity score was derived from 10 candidate proteins using LASSO Cox regression. Associations with incident heart failure (HF) and with cardiac function using Cox proportional hazards regression and linear regression models, respectively. The mean ages at Visits 3 and 5 were 60 ± 6 and 75 ± 5 years, respectively, and 54% and 57% were women, respectively. Each 1‐standard deviation increase in the neutrophil activity score was associated with a higher risk of incident HF in mid‐life (hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.25–1.37) and late‐life (HR 1.23, 95% CI 1.14–1.34), with a higher HR for HF with preserved than reduced ejection fraction (HR 1.30, 95% CI 1.16–1.47 vs. HR 1.13, 95% CI 0.98–1.30). Higher neutrophil activity was associated with greater left ventricular end‐diastolic volume index, mass index and diastolic and systolic dysfunction.ConclusionsPlasma proteins related to neutrophil function associate with incident HF in mid‐ and late‐life and with adverse cardiac remodelling. Therapies that modify these proteins, such as colchicine, may represent promising targets for the prevention or treatment of HF.
One‐Pot Catalytic Synthesis of Optically Active Drug (S)‐Clopidogrel
Authors: Battaglia Vincenzo , Meninno Sara , Lattanzi Alessandra 
Published: August 2023

AbstractA first catalytic preparation of the popular antiplatelet drug (S)‐clopidogrel, known with the tradename of Plavix, has been developed in a one‐pot and innovative approach. The synthesis can be performed using commercially available ortho‐chlorobenzaldehyde, 1‐naphthylsulfonyl acetonitrile, tert‐butyl hydroperoxide (TBHP), 4,5,6,7‐tetrahydrothieno[3,2‐c]pyridine and 20 mol % of a quinidine derived organocatalyst in a single solvent. A Knoevenagel/asymmetric epoxidation/domino ring‐opening esterification (DROE) sequence enabled to obtain (S)‐clopidogrel in 61 % overall yield and 62 % ee. Fine optimization of the reaction conditions proved to be crucial to set up a selective and efficient process.
Unconventional strategies to break through the efficiency of light‐driven water splitting: A review
Authors: Wang Kang , Huang Dingwang , Li Xiaowei , Feng Kuang , Shao Ming , Yi Jiabao , He Weidong , Qiao Liang 
Published: August 2023

AbstractSemiconductor‐based solar‐driven water splitting technology is an environmentally friendly and cost‐effective approach for the production of clean fuels. The overall solar‐to‐hydrogen efficiency of semiconductor‐based photo(electro)catalysts is jointly determined by factors, such as light absorption efficiency of the photo(electro)catalysts, internal separation efficiency of charge carriers, and injection efficiency of surface charges. However, the traditional improvement strategies, such as morphology control, functional layer modification, and band alignment engineering, still have certain limitations in enhancing the conversion efficiency of the photo(electro)catalytic water splitting. Recently, unconventional enhancement strategies based on surface plasmonic effects, piezoelectric effects, thermoelectric effects, and magnetic effects have provided unique pathways for improving the solar‐to‐hydrogen efficiency of photo(electro)catalysts. Therefore, this review outlines the fundamental concepts of these physical effects and elucidates their intrinsic mechanisms in enhancing the efficiency of photo(electro)catalysts for water splitting process through practical application examples. Ultimately, the future development of unconventional strategies for enhancing photo(electro)catalytic water splitting is envisioned.
Drift‐based risk‐oriented method for the explicit consideration of ground motion duration in seismic design
Authors: Bhanu Vishvendra , Chandramohan Reagan , Sullivan Timothy 
Published: August 2023

AbstractThis study proposes a method to explicitly account for ground motion duration in seismic design by modifying structural deformation capacity. An equation is presented to adjust the design drift limit prescribed in the New Zealand standard NZS 1170.5, based on the anticipated reduction in structural deformation capacity for ground motion durations longer than a critical value. The proposed relationship is used to derive designs corresponding to three duration targets each for two case‐study steel moment frame buildings ‐ a 4‐storey and a 12‐storey, located on a site in Nelson, New Zealand. Hazard‐consistent collapse risk assessment of the design versions is conducted using a structural reliability framework employing incremental dynamic analysis. Results indicate that buildings designed for lower drift limits have a lower mean annual frequency of collapse. The application of the proposed method is found to reduce the variation in the collapse risk of steel frame buildings designed for different duration targets, compared to the existing approach. The method proposed in this study is simple and easy for practical applications and can be modified for other design codes and a range of structural typologies.
Fiber intake and risk of chronic obstructive pulmonary disease: A systematic review and dose response meta‐analysis
Authors: Valisoltani Neda , Ghoreishy Seyed Mojtaba , Imani Hossein , Rajabi Harsini Asma , Jowshan Mohammadreza , Travica Nikolaj , Mohammadi Hamed 
Published: August 2023

AbstractThis systematic review and dose–response meta‐analysis examined the risk of chronic obstructive pulmonary disease (COPD) following dietary fiber intake. Relevant articles were retrieved from a variety of databases, including Scopus, Embase, and Medline, until March 2023. Spirometry was the most frequently used method for determining the presence of COPD. Based on the search, there were a total of 213,912 participants across five separate studies. Random effects model was used to combine the data and a dose–response analysis was further conducted. Five distinct cohort studies were identified. Based on highest versus lowest analysis, there was an inverse correlation between the intake of total fiber (RR, 0.72; 95%, CI: 0.64–0.80), cereal fiber (RR: 0.76, 95% CI 0.68, 0.86), and fruit fiber (RR: 0.75, 95% CI: 0.68, 0.83). Although this result was not significant for vegetable fiber (RR, 0.95; 95% CI, 0.84–1.07). Dose–response analysis revealed that daily increase of 10 g of total dietary fiber, cereal fiber, or fruit fiber reduced the risk of COPD by 26%, 21%, and 37%, respectively. The ROBINS‐E tool classified all cohort studies as having a moderate risk of bias. Total fiber, cereal fiber, and fruit fiber intake were found to have low credibility using the NutriGrade tool. Additionally, there is a lack of scientific evidence supporting the use of vegetable fiber. Larger, more comprehensive studies are required to confirm these findings.
Social perception in deaf individuals: A meta‐analysis of neuroimaging studies
Authors: Arioli Maria , Segatta Cecilia , Papagno Costanza , Tettamanti Marco , Cattaneo Zaira 
Published: August 2023

AbstractDeaf individuals may report difficulties in social interactions. However, whether these difficulties depend on deafness affecting social brain circuits is controversial. Here, we report the first meta‐analysis comparing brain activations of hearing and (prelingually) deaf individuals during social perception. Our findings showed that deafness does not impact on the functional mechanisms supporting social perception. Indeed, both deaf and hearing control participants recruited regions of the action observation network during performance of different social tasks employing visual stimuli, and including biological motion perception, face identification, action observation, viewing, identification and memory for signs and lip reading. Moreover, we found increased recruitment of the superior‐middle temporal cortex in deaf individuals compared with hearing participants, suggesting a preserved and augmented function during social communication based on signs and lip movements. Overall, our meta‐analysis suggests that social difficulties experienced by deaf individuals are unlikely to be associated with brain alterations but may rather depend on non‐supportive environments.
A selection and targeting framework of cortical locations for line‐scanning fMRI
Authors: Heij Jurjen , Raimondo Luisa , Siero Jeroen C. W. , Dumoulin Serge O. , van der Zwaag Wietske , Knapen Tomas 
Published: August 2023

AbstractDepth‐resolved functional magnetic resonance imaging (fMRI) is an emerging field growing in popularity given the potential of separating signals from different computational processes in cerebral cortex. Conventional acquisition schemes suffer from low spatial and temporal resolutions. Line‐scanning methods allow depth‐resolved fMRI by sacrificing spatial coverage to sample blood oxygenated level‐dependent (BOLD) responses at ultra‐high temporal and spatial resolution. For neuroscience applications, it is critical to be able to place the line accurately to (1) sample the right neural population and (2) target that neural population with tailored stimuli or tasks. To this end, we devised a multi‐session framework where a target cortical location is selected based on anatomical and functional properties. The line is then positioned according to this information in a separate second session, and we tailor the experiment to focus on the target location. Anatomically, the precision of the line placement was confirmed by projecting a nominal representation of the acquired line back onto the surface. Functional estimates of neural selectivities in the line, as quantified by a visual population‐receptive field model, resembled the target selectivities well for most subjects. This functional precision was quantified in detail by estimating the distance between the visual field location of the targeted vertex and the location in visual cortex (V1) that most closely resembled the line‐scanning estimates; this distance was on average ~5.5 mm. Given the dimensions of the line, differences in acquisition, session, and stimulus design, this validates that line‐scanning can be used to probe local neural sensitivities across sessions. In summary, we present an accurate framework for line‐scanning MRI; we believe such a framework is required to harness the full potential of line‐scanning and maximize its utility. Furthermore, this approach bridges canonical fMRI experiments with electrophysiological experiments, which in turn allows novel avenues for studying human physiology non‐invasively.
Risk factors associated with higher scores in internalizing and externalizing behaviors in Chilean preschoolers
Authors: Bedregal Paula , Lermanda Victoria , Sierra Rodrigo , Viviani Paola 
Published: August 2023

AbstractEarly detection of behavioral disorders in children is necessary for intervention. Available data show a high prevalence of child and adolescent psychiatric disorders in Chile (22.5%), but behavioral problems in younger children have not been evaluated. This work assesses behavioral disorders in preschoolers and their association with sociodemographic variables of the family and the child. The data was collected during the impact assessment of the Biopsychosocial Development Support Program “Chile Crece Contigo”, using a multistage and representative random sample of 1377 preschoolers, aged between 30 and 48 months, who attended public health services. Homes were visited to apply a questionnaire and the Child Behavior Checklist (CBCL, 1.5–5 years). Results: Multivariable regression model for total raw scores shows that child's age, the number of chronic diseases in the child, and history of exposure to mother's alcohol consumption in pregnancy, remain significant when adjusted for all variables included (R2 of 17.8% and η2 of .19 (95% CI: .14–.22)). In externalizing and internalizing explanatory models, child's chronic diseases and a higher score of authoritarian beliefs about parenting show the two largest effect sizes. These results add to the evidence of urgent problems in preschool mental health.
Evaluations of heart rate during functional analyses of destructive behavior
Authors: McCabe Liam H. , Greer Brian D. 
Published: August 2023

AbstractPrevious research has examined the predictive validity of heart rate on destructive behavior; however, such research has yet to improve clinical practice or enhance our understanding of the relation between physiology and destructive behavior. The purpose of this study was to examine the predictive validity of heart rate on varying topographies and functions of destructive behavior while controlling antecedent and consequent events through functional analysis. We first demonstrated the reliability of the Polar H10 heart rate monitor and assessed the feasibility of its use in simulated functional analysis sessions. However, across four consecutively enrolled patients, heart rate was not found to be a reliable predictor of destructive behavior, regardless of its topography or function. Instead, functional reinforcer presence and absence was sufficient to predict socially reinforced destructive behavior. This study may provide a framework for the future assessment of other biological measures in relation to destructive behavior occurrence and nonoccurrence.
Applications of time‐resolved step‐scan Fourier‐transform infrared spectroscopy in revealing the light‐initiated reactions in condensed phases
Authors: Chu Li‐Kang 
Published: August 2023

AbstractStep‐scan Fourier‐transform infrared spectroscopy (ssFTIR) simultaneously provides the spectroscopic and kinetic information of a given reaction. ssFTIR has been extensively employed to acquire the transient absorption and emission spectra in gas phase for identifying unstable species, for example, various Criegee intermediates, and elucidating the dynamics and kinetics of the reaction, such as the molecular elimination dynamics of haloalkenes and the bimolecular reactions involving chlorine atoms and singlet oxygen atoms. In addition to gaseous studies, ssFTIR has been also utilized to record the time‐resolved difference spectra of the photochemical reactions in condensed phases, such as the photolysis of metal–ligand complexes, photocycles of the retinal proteins, coordination capability of solvents to unstable transient species, chemical reactions of atmosphere‐related molecules in aqua, and the exciplex dynamics of organic light emitting materials. Moreover, my group has pioneered the recording of the transient thermal infrared emission of gold nanostructures upon photoexcitation. The experimental setups and the working principles for probing the time‐resolved infrared absorption and emission in condensed phases will be revealed and a number of studies on chemical, biological, and materials systems will be described. These reported results demonstrate that ssFTIR is a versatile tool for exploring the properties of novel materials and photoreactions in condensed phases.
Structural and immunohistochemical characterization of pancreas of Molly fish (Poecilia sphenops), with a special reference to its immune role
Authors: Hussein Marwa M. , Sayed Ramy K. A. , Mokhtar Doaa M. 
Published: August 2023

AbstractRecently, teleost species have been considered important model systems for investigating different research areas including immunologic one. The available literature provides poor data about the localization and the structure of pancreas in Molly fish. Moreover, little attention has been paid to the immunologic role of pancreatic tissue of teleost, particularly Molly fish; therefore, this study aimed to highlights the description of pancreatic tissue in Molly fish using light‐ and electron‐ microscopy, focusing on the role of pancreatic immune cells and pancreatic acinar cells in immune responses. Microscopic analysis revealed that the pancreas of Molly fish was composed of intrahepatic, disseminated and compact parts. Exocrine pancreatic tissue was diffusely extended within the hepatic tissue forming hepatopancreas. The disseminated pancreas appeared as several irregular nodules of pancreatic tissue localized within the mesenteric adipose tissue. The compact pancreas appeared as an oval shaped body embedded within the mesenteric adipose tissue between the spleen and the intestinal loops. Several telocytes and melanomacrophages were detected within the disseminated pancreatic nodules. Moreover, dendritic cells were found in a close association to the exocrine pancreatic acini. The pancreatic acinar cells showed strong immunoreactivity to APG5, TGF‐β, IL‐1β, NF‐κB, Nrf2, and SOX9 in both hepatopancreas and disseminated pancreas of Molly fish. S100 protein revealed a strong expression in the exocrine pancreatic acinar cells of disseminated pancreas and also in the endocrine cells of the compact pancreas. In conclusion, findings of this study suggest the potential role of the pancreas of the Molly fish in cell proliferation and differentiation, proinflammatory cytokines stimulation, and regulation of both innate and adaptive immunity.Research Highlights
Telocytes and melanomacrophages were detected in the disseminated pancreatic nodules of the Molly fish.
In Molly fish, dendritic cells were found in a close association to the exocrine pancreatic acini.
Strong immunoreactivity of the pancreatic acinar cells of the Molly fish to APG5, TGF‐β, IL‐1β, NF‐κB, Nrf2, SOX9, and S100.
Cross‐cultural adaptation of the Genetic Counseling Outcome Scale (GCOS‐24) for use in Canada: A qualitative study
Authors: Redondo Laura , McAllister Marion 
Published: August 2023

AbstractThe Genetic Counselling Outcome Scale (GCOS)‐24 is a patient‐reported outcome measure (PROM) developed and validated in the United Kingdom (UK). The aim of this study was to cross‐culturally adapt GCOS‐24 to Canadian Clinical Genetic Services (CGS). This was achieved through a qualitative study exploring whether the existing GCOS‐24 maintains its intended meaning in a Canadian population and assessing whether GCOS‐24 items could be better worded to meet the needs of members of families affected by genetic conditions in Canada. Thirteen participants were recruited from Canadian Patient Organizations supporting people and families affected by genetic conditions. Data were collected through semi‐structured cognitive interviews, as these allow exploration of participants' comprehension, opinions, thoughts, and feelings regarding GCOS‐24's instructions, response options, and the meaning/relevance of each item. Thematic analysis was utilized for data analysis, and an inductive approach to coding was followed to allow for themes to emerge from the data. Themes were organized in respect to their questionnaire item and further classified into their respective Empowerment dimension. The GCOS‐24 instructions were found easy to understand by all thirteen participants. Although the response options were also found to be straightforward, the data suggest the questionnaire would benefit from the addition of a “non‐applicable” option. Semantic validation of the GCOS‐24 showed that items within the Cognitive Control and Emotional Regulation dimensions were found easy to understand by participants. However, items within the Decisional Control, Behavioural Control and Hope dimensions presented semantic difficulties. Participants provided feedback on syntactic changes to support understanding, and this feedback was used to develop a final Canadian‐adapted version of GCOS‐24, GCOS‐Canada. This study provides the first step towards a valid, culturally adapted PROM for use in Canadian CGS service evaluation and research. GCOS‐Canada would benefit from psychometric validation to ensure validity, reliability, responsiveness, minimal clinically important difference and internal consistency.
Overview of mathematical background of homogenization, summary of method MASH and comments on benchmark validation
Authors: Szentimrey Tamás 
Published: August 2023

AbstractThere are several methods and software for the homogenization of climate data series but there is not any exact mathematical theory of homogenization. As we see, the basic problem of homogenization is the unreasonable dominance of the practical procedures over the theory. Therefore we try to formulate some questions of homogenization in accordance with the mathematical conventions. The topics to be discussed are as follows. (a) Themes and systems—meteorological, mathematical and software links. (b) Mathematical formulation of climate data series homogenization and special case of normal distribution. (c) Additive and multiplicative spatiotemporal models for climate data series homogenization. (d) Mathematical overview of methodological questions as, spatial comparison of series, inhomogeneity detection and adjustment of series, in accordance with the WMO Guidelines on Homogenisation (2020). (e) The last topic is the new version of MASH for homogenization of mean and standard deviation. The earlier versions of our method MASH (Multiple Analysis of Series for Homogenization; Szentimrey) were developed formerly at the Hungarian Meteorological Service. These procedures aimed to homogenize the daily and monthly data series in the mean, that is, the first order moment. The new version MASHv4.01 has been developed for joint homogenization of mean and standard deviation using some mathematical results. Theoretically, in case of normal distribution, the homogenization of mean and standard deviation is sufficient since if the first two moments are homogenous then the higher order moments are also homogeneous. An interactive automatic algorithm also was developed in this new version in order to make the homogenization easier for the users. We will present a summary of the software MASH where our intention was to develop a flexible, interactive automatic, artificial intelligence (AI) system. We finish the paper with some comments connected to the theoretical evaluation and benchmark validation of the methods.