bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrasi Aplikasi Manajemen Praktikum dan Tugas Akhir dengan Kredit Poin Mahasiswa Berbasis Android Untuk Mempermudah Dosen Dalam Memonitoring Kegiatan Mahasiswa
Authors: Rizal Fathur , Julianto Erik Eko , Firmansyah Edi , Jannah Nuril Lukluwatil 
Published: February 2023

Sistem kredit poin mahasiswa dan Sistem informasi monitoring praktikum dan tugas akhir yang terdapat di Universitas Nurul Jadid saat ini masih belum terintegrasi dengan baik. Hal ini meminbulkan permasalahan dosen atau pun mahasiswa sering meminta akun untuk dapat mengakses aplikasi monitoring bimbingan kembali saat pelaksanaan praktikum dilaksanaan serta dosen maupun mahasiswa harus melskukan instalasi dua aplikasi tersebut dan menggunakan akun yang berbeda untuk dapat menggunakan dua sistem yang ada. Oleh sebab itu, penelitian ini bertujuan untuk mengintegrasikan dua sistem yang ada menjadi satu sistem yang terpadu sehingga dapat mengatasi masalah yang ada. Metode yang digunakan dalam penelitian ini yakni menggunakan Reseach and Development serta Model Prototyping dalam pengembangan sistemnya. Penelitian ini menghasilkan satu sistem terpadu dari dua sistem yang ada sebelumnya. Hasil pengujian diperoleh 15% responden menyatakan baik terhadap user interface, 49% menyatakan baik terhadap user experiences, 47% menyatakan sangat baik terhadap functionality, 49% menyatakan sangat baik terhadap usable dan 47% menyatakan baik terhadap friendly sistem yang telah dikembangkan
Sistem Pakar Diagnosa Penyakit Tanaman Cabe Menggunakan Metode Forward Chaining Berbasis Web (Studi Kasus BPP Mlandingan)
Authors: Wijaya Andi , Shudiq Wali Ja'far , Purnomo Eko 
Published: February 2023

Tanaman cabe (Capsicum annuum L) merupakan tanaman sayuran yang tergolong tanaman tahunan berbentuk perdu. Penyakit tanaman adalah gangguan pada tanaman yang disebabkan oleh mikro organisme (virus, bakteri, protozoa, jamur, cacing nematoda). Permasalahan pada penelitian ini adalah minimnya pengetahuan petani dalam mendiagnosa penyakit yang sedang dialami pada tanaman cabe. Metode yang di gunakan adalah metode Forward Chaining. Metode ini digunakan sebagai sebagai salah satu teknik inferensi dalam sistem pakar ini, dikarenakan data dan fakta dalam melakukan proses penelitian telah didapatkan dan dari data atau fakta tersebut dapat dibuat sebuah sistem yang akan memberikan sebuah konklusi atau solusi berdasarkan atas sekumpulan data dan fakta tersebut. Dengan menggunakan teknik inferensi ini pula peluang dalam mendapatkan suatu konklusi yang lebih spesifik dapat dengan mudah didapatkan.tujuan dari penelitian ini adalah menghasilkan suatu sistem pakar diagnosa penyakit tanaman cabe menggunakan metode Forward Chaining berbasis web sehingga dapat membantu petani dalam mendiagnosa penyakit tanaman cabe. Model pengembangan yang digunakan pada penelitian ini adalah model waterfal, model waterfall (air terjun) artinya menyediakan pendekatan alur perangkat lunak yang terurut dimulai dari analisis, desain, pengkodean, uji sistem dan perawatan. Hasil pengujian terhadap user, dapat di simpulkan bahwa aplikasi sistem pakar diagnosa penyakit tanaman cabe menggunakan metode Forward Chaining berbasis web telah 68% baik untuk digunakan.
Algoritma Decision Tree Dengan Menggunakan Pruning dan Missing Value Untuk Prediksi Kredit Macet
Authors: Inda Arifin Nur Hatima , Shudiq Wali Ja'far 
Published: February 2023

Sebagai industri yang mempunyai perkambangan sangat pesat yang di ikuti dengan resiko kredit pada setiap kegiatan usaha perbankan. Kredit merupakan penghasilan utama dari sebuah perbankan dan juga merupakan sumber resiko terbesar karena sebagian besar dana operasional bank berputar dalam bentuk kredit. Proses data nasabah, data jaminan hingga pada proses pengambilan keputusan menjadi peran penting untuk menekan dan mengurangi resiko bagi pihak pengajuan kredit. Syarat perbankan menjadi indikator pemberian pinjaman kepada nasabah agar layanan yang diberikan tepat dan tidak memberikan efek buruk pada manajemen bank , misalnya kredit macet [2]. Tujuan dari penelitian ini adalah untuk memprediksi tingkat resiko kredit yang terjadi pada sebuah perbankan. Berdasarkan beberapa metode yang telah diusulkan dan telah dilakukan prediksi kredit macet, menghasilkan nilai akurasi terendah. Dalam penelitian ini menggunakan metode pruning pada missing value dengan menerapkan Algoritma decision tree untuk prediksi kredit macet dengan jumlah dataset sebanyak732 record dengan 11 variabel dan terdapat data yang tidak lengkap (missing value) pada salah satu variable dataset kredit macet. Pada pengujian algoritma decision tree dengan metode pruning berhasil meningkatkan nilai akurasi menjadi 75.80%, sedangkan algoritma decision tree tanpa metode pruning hasil akurasinya adalah 72.61%.
Deciphering the microbial community structures and functions of wastewater treatment at high-altitude area
Authors: Zhu Yuliang , Liu Yucan , Chang Huanhuan , Yang Hao , Zhang Wei , Zhang Yanxiang , Sun Hongwei 
Published: February 2023

Introduction: The proper operation of wastewater treatment plants is a key factor in maintaining a stable river and lake environment. Low purification efficiency in winter is a common problem in high-altitude wastewater treatment plants (WWTPs), and analysis of the microbial community involved in the sewage treatment process at high-altitude can provide valuable references for improving this problem.Methods: In this study, the bacterial communities of high- and low-altitude WWTPs were investigated using Illumina high-throughput sequencing (HTS). The interaction between microbial community and environmental variables were explored by co-occurrence correlation network.Results: At genus level, Thauera (5.2%), unclassified_Rhodocyclaceae (3.0%), Dokdonella (2.5%), and Ferribacterium (2.5%) were the dominant genera in high-altitude group. The abundance of nitrogen and phosphorus removal bacteria were higher in high-altitude group (10.2% and 1.3%, respectively) than in low-altitude group (5.4% and 0.6%, respectively). Redundancy analysis (RDA) and co-occurrence network analysis showed that altitude, ultraviolet index (UVI), pH, dissolved oxygen (DO) and total nitrogen (TN) were the dominated environmental factors (p &lt; 0.05) affecting microbial community assembly, and these five variables explained 21.4%, 20.3%, 16.9%, 11.5%, and 8.2% of the bacterial assembly of AS communities.Discussion: The community diversity of high-altitude group was lower than that of low-altitude group, and WWTPs of high-altitude aeras had a unique microbial community structure. Low temperature and strong UVI are pivotal factors contributing to the reduced diversity of activated sludge microbial communities at high-altitudes.
Safety and efficacy of direct oral anticoagulants in bioprosthetic valves: A systematic review and meta-analysis
Authors: Bakr Lubna , Elsayed Ahmed , Saleh Omar , Abdalraouf Mostafa , Ng Ghulam André , Ibrahim Mokhtar 
Published: February 2023

BackgroundDirect oral anticoagulants are efficient alternatives to vitamin K antagonists. There is little evidence regarding their use in patients who underwent bioprosthetic valve replacement whether surgically or through a transcatheter approach and have another indication of anticoagulation. Trials have compared different members of the DOACs family to VKAs and showed that they were at least non-inferior to VKAs with regard to safety and efficacy. However, this is still controversial. Our meta-analysis aims at providing a clearer view of their future use in this subgroup of patients.MethodsPubMed and Cochrane were searched for randomised clinical trials and observational studies. Bleeding, stroke, and all-cause mortality were the outcomes of interest.ResultsTen papers with a total of 4,088 patients were included. Our meta-analysis revealed no significant differences between the incidence of bleeding between DOACs and warfarin (16% vs. 17%, OR = 0.94, 95% CI [0.56–1.57], p = 0.81, I2 = 81%). No statistical difference was found in stroke between both groups (2.5% vs. 3.3%, OR = 0.75, 95% CI [0.41–1.38], p = 0.36, I2 = 35%). All-cause mortality was not statistically significant between both groups (9.2% vs. 13.7%, OR = 0.85, 95% CI [0.68–1.07], p = 0.16, I2 = 56%). Interestingly, subgroup analysis of randomised controlled trials and prospective studies favoured DOACs with lower risks of both bleeding and stroke.ConclusionDirect oral anticoagulants appear to be at least as safe and effective as VKAs in patients with bioprosthetic valves and another indication of anticoagulation. There could be potential benefit from the use of DOACs; however, further evidence is required.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021222146, identifier CRD42021222146.
Estimates of volcanic mercury emissions from Redoubt Volcano, Augustine Volcano, and Mount Spurr eruption ash
Authors: Kushner D. Skye , Lopez Taryn M. , Wallace Kristi L. , Damby David E. , Kern Christoph , Cameron Cheryl E. 
Published: February 2023

Ash is a potential sink of volcanically sourced atmospheric mercury (Hg), and the concentration of particle-bound Hg may provide constraints on Hg emissions during eruptions. We analyze Hg concentrations in 227 bulk ash samples from the Mount Spurr (1992), Redoubt Volcano (2009), and Augustine Volcano (2006) volcanic eruptions to investigate large-scale spatial, temporal, and volcanic-source trends. We find no significant difference in Hg concentrations in bulk ash by distance or discrete eruptive events at each volcano, suggesting that in-plume reactions converting gaseous Hg0 to adsorbed Hg2+ are happening on shorter timescales than considered in this study (minutes) and any additional in-plume controls are not discernable within intra-volcanic sample variability. However, we do find a significant difference in Hg concentration of ash among volcanic sources, which indicates that volcanoes may emit comparatively high or low quantities of Hg. We combine our Hg findings with total mass estimates of ashfall deposits to calculate minimum, first-order Hg emissions of 8.23 t Hg for Mount Spurr (1992), 1.25 t Hg for Redoubt Volcano (2009), and 0.16 t Hg for Augustine Volcano (2006). In particular, we find that Mount Spurr is a high Hg emitting volcano, and that its 1992 particulate Hg emissions likely contributed substantially to the global eruptive volcanic Hg budget for that year. Based on our findings, previous approaches that use long-term Hg/SO2 mass ratios to estimate eruptive total Hg under-account for Hg emitted in explosive events, and global volcanogenic Total Hg estimates need revisiting.
Thyroid autoimmunity and adverse pregnancy outcomes: A multiple center retrospective study
Authors: Xu Yun , Chen Hui , Ren Meng , Gao Yu , Sun Kan , Wu Hongshi , Ding Rui , Wang Junhui , Li Zheqing , Liu Dan , Wang Zilian , Yan Li 
Published: February 2023

BackgroundThe relationship between thyroid autoimmunity (TAI) and adverse pregnancy outcomes is disputable, and their dose-dependent association have not been fully clarified.ObjectiveTo investigate the association and dose-dependent effect of TAI with multiple maternal and fetal-neonatal complications.MethodsThis study is a multi-center retrospective cohort study based on singleton pregnancies of three medical college hospitals from July 2013 to October 2021. The evolution of thyroid function parameters in TAI and not TAI women were described, throughout pregnancy. The prevalences of maternal and fetal-neonatal complications were compared between the TAI and control group. Logistic regression was performed to study the risk effects and dose-dependent effects of thyroid autoantibodies on pregnancy complications, with adjustment of maternal age, BMI, gravidity, TSH concentrations, FT4 concentrations and history of infertility.ResultsA total of 27408 participants were included in final analysis, with 5342 (19.49%) in the TAI group and 22066 (80.51%) in control group. TSH concentrations was higher in TAI women in baseline and remain higher before the third trimester. Positive thyroid autoantibodies were independently associated with higher risk of pregnancy-induced hypertension (OR: 1.215, 95%CI: 1.026-1.439), gestational diabetes mellitus (OR: 1.088, 95%CI: 1.001-1.183), and neonatal admission to NICU (OR: 1.084, 95%CI: 1.004-1.171). Quantitative analysis showed that increasing TPOAb concentration was correlated with higher probability of pregnancy-induced hypertension, and increasing TGAb concentration was positively correlated with pregnancy-induced hypertension, small for gestational age and NICU admission. Both TPOAb and TGAb concentration were negatively associated with neonatal birthweight.ConclusionThyroid autoimmunity is independently associated with pregnancy-induced hypertension, gestational diabetes mellitus, neonatal lower birthweight and admission to NICU. Dose-dependent association were found between TPOAb and pregnancy-induced hypertension, and between TGAb and pregnancy-induced hypertension, small for gestational age and NICU admission.
Weighted gene co-expression network analysis identifies key hub genes and pathways in acute myeloid leukemia
Authors: Wang Xinfeng , Bajpai Akhilesh K. , Gu Qingqing , Ashbrook David G. , Starlard-Davenport Athena , Lu Lu 
Published: February 2023

Introduction: Acute myeloid leukemia (AML) is the most common type of leukemia in adults. However, there is a gap in understanding the molecular basis of the disease, partly because key genes associated with AML have not been extensively explored. In the current study, we aimed to identify genes that have strong association with AML based on a cross-species integrative approach.Methods: We used Weighted Gene Co-Expression Network Analysis (WGCNA) to identify co-expressed gene modules significantly correlated with human AML, and further selected the genes exhibiting a significant difference in expression between AML and healthy mouse. Protein-protein interactions, transcription factors, gene function, genetic regulation, and coding sequence variants were integrated to identify key hub genes in AML.Results: The cross-species approach identified a total of 412 genes associated with both human and mouse AML. Enrichment analysis confirmed an association of these genes with hematopoietic and immune-related functions, phenotypes, processes, and pathways. Further, the integrated analysis approach identified a set of important module genes including Nfe2, Trim27, Mef2c, Ets1, Tal1, Foxo1, and Gata1 in AML. Six of these genes (except ETS1) showed significant differential expression between human AML and healthy samples in an independent microarray dataset. All of these genes are known to be involved in immune/hematopoietic functions, and in transcriptional regulation. In addition, Nfe2, Trim27, Mef2c, and Ets1 harbor coding sequence variants, whereas Nfe2 and Trim27 are cis-regulated, making them attractive candidates for validation. Furthermore, subtype-specific analysis of the hub genes in human AML indicated high expression of NFE2 across all the subtypes (M0 through M7) and enriched expression of ETS1, LEF1, GATA1, and TAL1 in M6 and M7 subtypes. A significant correlation between methylation status and expression level was observed for most of these genes in AML patients.Conclusion: Findings from the current study highlight the importance of our cross-species approach in the identification of multiple key candidate genes in AML, which can be further studied to explore their detailed role in leukemia/AML.
Integrative analysis of the role of BOLA2B in human pan-cancer
Authors: Liang Mingxing , Fei Yinjiao , Wang Yalin , Chen Wenquan , Liu Zhen , Xu Di , Shen Hongyu , Zhou Honglei , Tang Jinhai 
Published: February 2023

Objective:BOLA2B is a recently discovered protein-coding gene. Here, pan-cancer analysis was conducted to determine the expression patterns of BOLA2B and its impact on immune response, gene mutation, and possible molecular biological mechanisms in different tumors, together with investigating its potential usefulness for cancer prognosis.Methods: Data on BOLA2B expression and mutations were downloaded from TCGA and GTEx databases. Clinical survival data from TCGA were used to analyze the prognostic value of BOLA2B. TIMER and ESTIMATE algorithms were used to assess correlations between BOLA2B and tumor-infiltrating immune cells, immune cytokines, and immune scores.Results: BOLA2B was found to be highly expressed at both mRNA and protein levels in multiple tumors, where it was associated with worse overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) in all cancers apart from ovarian cancer. BOLA2B was also found to be positively correlated with copy number variation (CNV), and mutations in TP53, TTN, and MUC16 were found to influence BOLA2B expression. Post-transcriptional modifications, including m5C, m1A, and m6A, were observed to regulate BOLA2B expression in all cancers. Functional analysis showed that BOLA2B was enriched in pathways associated with iron–sulfur cluster formation, mTOR-mediated autophagy, and cell cycle inhibition. Decreased BOLA2B expression induced the proliferation of breast cancer cells and G2/M cell cycle arrest.Conclusion:BOLA2B was found to be highly expressed in malignant tumors and could be used as a biomarker of poor prognosis in multiple cancers. Further investigation into BOLA2B’s role and molecular functions in cancer would provide new insights for cancer diagnosis and treatment.
Association between the site of clear corneal Phakic intraocular lens implantation incisions and the inflow of ocular surface fluid into the anterior chamber
Authors: Wan Huan , Tao Yunhan , Duan Jianan , Wang Lin , Tang Li 
Published: February 2023

BackgroundPosterior chamber phakic intraocular implantable collamer lens (ICL) implantation is an effective surgical option for the management of myopia. Over the past few years, the number of ICL surgeries has significantly increased. Postoperative inflammation and endophthalmitis are among the most serious complications after successful ICL surgery. Sometimes, when the blepharospasm is removed at the end of surgery, a small amount of the ocular surface fluid will flow into the anterior chamber, which can lead to an increased risk of infection and inflammation. However, little attention has been paid to this phenomenon.PurposeWe conducted a retrospective study to compare the incidence of extraocular fluid inflow into the eye through the clear corneal incision (CCI) at two different positions (superior and temporal sides).MethodsA total of 116 patients with myopia underwent superior CCI ICL implantation (n = 58) or temporal CCI ICL implantation (n = 58) at our hospital from October to December 2021. The incidence of conjunctival sac fluid entering the anterior chamber after eyelid fixative was removed was compared in both groups.ResultsBoth groups were well matched in all parameters. Ocular surface fluid inflow into the anterior chamber was significantly higher in the superior CCI group (25/58, 47.1%) than in the temporal CCI group (1/58, 1.7%) (p &lt; 0.05).ConclusionIn the patients with ICL implantation, the temporal CCI was better than the superior CCI in avoiding the ocular surface fluid inflow into the anterior chamber, and the potential risk of infection and inflammation was lower.
Stroke territory and atherosclerosis in ischemic stroke patients with a history of migraine with aura
Authors: Altamura Claudia , Viticchi Giovanna , Rizzo Angelo Cascio , Maggio Paola , Brunelli Nicoletta , Marcosano Marilena , Lazzaro Vincenzo Di , Fiacco Fabrizio , Agostoni Elio Clemente , Silvestrini Mauro , Vernieri Fabrizio 
Published: February 2023

IntroductionThe mechanisms subtending the increased stroke risk in migraine with aura (MA) are not fully understood. Our study aims to evaluate if the clinical profile in stroke patients with MA differentiates from those without MA.MethodsWe retrieved the prospective registered electronic clinical dossiers of adult patients younger than 60 years with acute ischemic stroke admitted in four hospitals between January 2016 and June 2022. Patients were classified by the history of MA (MA+ and MA–).ResultsWe identified 851 stroke patients (59 MA+, 6.9%). Compared to MA−, MA+ patients were characterized by younger age (44.0 ± 10.6 vs 50.1 ± 8.2 years), female sex (59.3% vs 29.0%), and affected by cryptogenic (OR 2.594 95% CI 1.483–4.537), and cerebellar stroke (OR 3.218 95% CI 1.657–6.250; p ≤ 0.001 for all comparisons). After adjusting for age and sex, MA+ patients presented less frequently hypertension (OR 0.349 95% CI 0.167–0.470; p=0.005) and dyslipidemia (OR 0.523 95% CI 0.280–0.974; p = 0.041). After adjusting also for risk factors, the MA+ group had less frequently symptomatic large vessel stenosis (OR 0.126 95% CI 0.017–0,924; p = 0.042) and clinical atherosclerosis (OR 0.103 95% CI 0.014–0.761; p = 0.026), while intima–media thickness did not differ (p = 0.395).DiscussionCryptogenic and cerebellar stroke and fewer vascular risk factors and clinical atherosclerosis seem to characterize stroke patients with MA.
Increased low frequency fluctuation in the brain after acupuncture treatment in CSVDCI patients: A randomized control trial study
Authors: Yang Nan , Chen Sina , Liu Shuxue , Ling Shuiqiao , Chen Lidian 
Published: February 2023

BackgroundCerebral small vessel disease (CSVD) is one of two cognition-impairing diseases. Acupuncture (Acu) is a flexible treatment with few adverse effects and is thus widely used to treat neurological problems.MethodsWe recruited a total of 60 patients and assigned them to two groups (n = 30 each group). During the study, some participants were excluded by quality control, and a total of 44 subjects (25 Acu and 19 controls) were completed to investigate the therapeutic efficacy of acupuncture on CSVD cognitive impairment (CSVDCI). The following demographic and clinical variables were compared between the two groups: gender, age, education, smoking, alcohol, Montreal cognitive assessment (MoCA), symbol digit modalities test (SDMT), verbal fluency test (VFT), digit span task (DST), Boston naming test (BNT) scores, and amplitude of low-frequency fluctuation (ALFF) under the typical band (0.01–0.08 Hz). Mixed effect analysis was utilized to test for differences between the two groups before and after the treatment.ResultsFollowing acupuncture treatment, the Acu group scored higher on MoCA, SDMT, VFT, DST, and BNT compared to controls (P &lt; 0.05). The brain regions showing substantially greater ALFF values in the Acu group were the right inferior temporal gyrus, left middle occipital gyrus, left superior occipital gyrus, left insula, bilateral postcentral gyrus, right superior parietal gyrus, right cerebellum, right precuneus, and right precentral gyrus (P &lt; 0.005, no correction). The ALFF values in the right inferior temporal gyrus (P = 0.027), left middle occipital gyrus (P = 0.005), left superior occipital gyrus (P = 0.011), and right superior parietal gyrus (P = 0.043) were positively associated with MoCA.ConclusionWe found that acupuncture modulates the functional activity of temporal, occipital, and parietal regions of the brain in CSVDCI patients.