bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a standardized minimum dataset for including low‐severity trauma patients in trauma registry collections in Australia and Aotearoa New Zealand
Authors: Christey Grant , Warren Jacelle , Palmer Cameron S. , Burrell Maxine , Vallmuur Kirsten 
Published: March 2023

AbstractBackgroundTrauma continues to place a burden on individuals, communities and health care systems around the world. To help reduce this burden and improve care, trauma registries in Australia and Aotearoa New Zealand collect standardized data on patients admitted with Injury Severity Scores greater than 12. There is currently no agreed minimum data set for trauma patients with Injury Severity Score less than 13, representing an opportunity to provide more data for quality improvement and injury prevention.MethodsA binational, expert, advisory group assessed the value of potential fields for a minimum dataset for low severity trauma. Existing trauma registries in Australia and Aotearoa New Zealand were assessed to ensure compatibility.ResultsThirty‐five data fields met criteria for inclusion in the low‐severity minimum dataset. The fields comprised a subset of the Australia New Zealand Major Trauma Registry and were included in existing low‐severity registries.ConclusionA minimum data set for low severity has been defined for use in Australia and Aotearoa New Zealand. In addition to high severity trauma data this will provide a standard for data collection that will contribute to quality improvement and injury prevention.
Highstand sublacustrine fans: The role of a sudden increase in sediment supply
Authors: Yang Tian , Cao Yingchang , Liu Haining 
Published: March 2023

AbstractContrary to widely used traditional sequence‐stratigraphic models, highstand sublacustrine fans developed in the deep‐water environment in the middle of the third member of the Eocene Shahejie Formation (Es3z, 42–40.5 Ma), Dongying Sag. Using four cores and 3D seismic data, we describe the sequence stratigraphy frameworks, sediment characteristics, depositional elements, and depositional model of the Liangjialou highstand sublacustrine fan. The Es3z is a complete third‐order sequence stratigraphic, bounded by T4 at the top and T6 at the base. Between T4 and T6, there is the maximum flooding surface (MFS) distributed from proximal to distal of the system in the third‐order stratigraphic sequence. Therefore, the Liangjialou Fan at the top of the Es3z, between MFS and T4, is a typical highstand sublacustrine fan as determined from seismic data. This highstand sublacustrine fan is characterised by gravel to fine‐grained sand, abundant amalgamation surfaces, and crude stratifications common in coarse‐grained structureless‐ to normal‐ graded sandstones. Climbing ripples and thin laminae rich in plant debris are common in inverse‐then normal‐graded sandstones. Channel‐levee, channel‐lobe transition zone, and lobes developed in this highstand sublacustrine fan, with clear internal progradation stacking patterns caused by hyperpycnal flow. The sudden increase in sediment supply in an accommodation decrease situation and the narrow shelf width are the primary controlling factors for forming highstand sublacustrine fans. In the late stage of the highstand systems tract, gravity‐flow deposits caused by hyperpycnal flow are developed from another new point source to form this highstand sublacustrine fan. Hyperpycnal flow in lacustrine basins can transport coarse‐grained sediments with the help of strong flood energy and steep slopes. Gravity flow deposits in lacustrine basins are not confined by sequence stratigraphy frameworks, and many additional areas of sand caused by hyperpycnal flow could be found in lacustrine basins.
Operationalising children's participation: Competing understandings of the policy to practice ‘gap’
Authors: Michail Samia , Baird Kelly , Fattore Tobia , Grace Rebekah 
Published: March 2023

AbstractThere is widespread discourse and policy on children's participation in decision‐making. This is not matched with an equal level of implementation in practice. This qualitative research explores the policy to practice gap with senior decision makers in the child protection system in New South Wales (NSW), Australia. Their reflections on the challenges associated with translating the participation principles into practice are deconstructed to understand the complex and overlapping ways in which participation is perceived. The research data indicate there are competing understandings of participation at play, depending on the actor, their role and organisation. This paper suggests that genuine participation in practice relies on bridging the epistemic differences and interests of different stakeholder groups who are all critical to achieving children's participation in service decision‐making.
Proangiogenic role of circRNA‐007371 in liver fibrosis
Authors: Zhao Chong , Qian Shuaijie , Tai Yang , Guo Yangkun , Tang Chengwei , Huang Zhiyin , Gao Jinhang 
Published: March 2023

AbstractCircular RNAs (circRNAs) are crucially involved in cancers as competing endogenous RNA (ceRNA) or microRNA (miRNA) sponges. However, the function and mechanism of circRNAs in liver fibrosis remain unknown and are the focus of this study. Murine fibrotic models were induced by thioacetamide (TAA) or carbon tetrachloride (CCl4). Increased angiogenesis is accompanied by liver fibrosis in TAA‐ and CCl4‐induced murine fibrotic livers. circRNA microarray and argonaute 2 (AGO2)‐RNA immunoprecipitation (RIP) sequencing (AGO2‐RIP sequencing) were performed in murine livers to screen for functional circRNAs. Compared to control livers, 86 differentially expressed circRNAs were obtained in TAA‐induced murine fibrotic livers using circRNA microarray. In addition, 551 circRNAs were explored by AGO2‐RIP sequencing of murine fibrotic livers. The circRNA‐007371 was then selected and verified for back‐spliced junction, resistance to RNase R, and loop formation. In vitro, murine hemangioendothelioma endothelial (EOMA) cells were transfected with circRNA‐007371 overexpressing plasmid or empty plasmid. circRNA‐007371 overexpression promoted tube formation, migration, and cell proliferation of EOMA cells. RNA sequencing and miRNA sequencing were then performed to explore the mechanism of the proangiogenic effects of circRNA‐007371. circRNA‐007371 promotes liver fibrosis via miRNA sponges or ceRNA mechanisms. Stag1, the parent gene of circRNA‐007371, may play a significant role in proangiogenic progression. In conclusion, circRNA‐007371 enhances angiogenesis via a miRNA sponge mechanism in liver fibrosis. The antiangiogenic effect of circRNA‐007371 inhibition may provide a new strategy for treating patients with liver cirrhosis.
Allometric body shape indices, type 2 diabetes and kidney function: A two‐sample Mendelian randomization study
Authors: Kjaergaard Alisa D. , Krakauer Jesse , Krakauer Nir , Teumer Alexander , Winkler Thomas W. , Ellervik Christina 
Published: March 2023

AbstractAimTo examine the association between body mass index (BMI)‐independent allometric body shape indices and kidney function.Materials and methodsWe performed a two‐sample Mendelian randomization (MR) analysis, using summary statistics from UK Biobank, CKDGen and DIAGRAM. BMI‐independent allometric body shape indices were: A Body Shape Index (ABSI), Waist‐Hip Index (WHI) and Hip Index (HI). Kidney function outcomes were: urinary albumin‐to‐creatinine ratio (UACR), estimated glomerular filtration rate and blood urea nitrogen. Furthermore, we investigated type 2 diabetes (T2D) as a potential mediator on the pathway to albuminuria. The main analysis was inverse variance‐weighted random‐effects MR in participants of European ancestry. We also performed several sensitivity MR analyses.ResultsA 1‐standard deviation (SD) increase in genetically predicted ABSI and WHI levels was associated with higher UACR (β = 0.039 [95% confidence interval: 0.016, 0.063] log [UACR], P = 0.001 for ABSI, and β = 0.028 [0.012, 0.044] log [UACR], P = 6 x 10−4 for WHI) in women, but not in men. Meanwhile, a 1‐SD increase in genetically predicted HI was associated with lower UACR in women (β = −0.021 [−0.041, 0.000] log [UACR], P = 0.05) and in men (β = −0.026 [−0.058, 0.005] log [UACR], P = 0.10). Corresponding estimates in individuals with diabetes were substantially augmented. Risk of T2D increased for genetically high ABSI and WHI in women (P < 6 x 10−19) only, but decreased for genetically high HI in both sexes (P < 9 x 10−3). No other associations were observed.ConclusionsGenetically high HI was associated with decreased risk of albuminuria, mediated through decreased T2D risk in both sexes. Opposite associations applied to genetically high ABSI and WHI in women only.
An observational study on monoclonal antibodies against calcitonin‐gene‐related peptide and its receptor
Authors: Schiano di Cola Francesca , Bolchini Marco , Ceccardi Giulia , Caratozzolo Salvatore , Liberini Paolo , Rao Renata , Padovani Alessandro 
Published: March 2023

AbstractBackground and purposeBased on their pharmacological target, two classes of calcitonin‐gene‐related peptide (CGRP) monoclonal antibodies (mAbs) have been identified: antibodies against the CGRP ligand—galcanezumab, fremanezumab, eptinezumab—and antibodies against the CGRP receptor (CGRP‐R), erenumab. The aim of the present study was to compare anti‐CGRP versus anti‐CGRP‐R mAbs in patients with high frequency episodic and chronic migraine.MethodsAll patients on monthly treatment with anti‐CGRP mAbs with an available 6 months’ follow‐up at January 2022 were included. Data on efficacy outcome were collected following one (T1), three (T3) and six (T6) months of treatment, and included monthly headache/migraine days, the Migraine Disability Assessment Scale (MIDAS) and Headache Impact Test 6 (HIT‐6) scores, pain intensity, analgesics consumption and response rates (>50% headache days reduction compared to baseline).ResultsIn all, 152 patients were enrolled, of whom 68 were in treatment with anti‐CGRP mAbs (49 galcanezumab, 19 fremanezumab) and 84 with the anti‐CGRP‐R (erenumab). MIDAS scores were significantly lower in the anti‐CGRP group at T1 and T3 (respectively p < 0.02 and p < 0.03) as well as the number of mean migraine days at T3 (p < 0.01). At T3 and T6 outcome measures were comparable, although a significantly higher percentage of super‐responders was found in the anti‐CGRP group (respectively p < 0.04 and p < 0.05), with a similar overall percentage of responders.ConclusionsThe present study on a real‐world sample confirms the beneficial effect of both anti‐CGRP and anti‐CGRP‐R mAbs, with a more favorable outcome for anti‐CGRP antibodies.
Relationship between common telomere length‐related genetic variations, telomere length, and risk of antituberculosis drug‐induced hepatotoxicity in Chinese Han population: As assessed for causality using the updated Roussel Uclaf Causality Assessment Method
Authors: Chen Xinyu , Hao Zhuolu , Pan Hongqiu , Liu Wenpei , Lu Lihuan , Zhang Meiling , He Xiaomin , Yi Honggang , Tang Shaowen 
Published: March 2023

AbstractAntituberculosis drug‐induced hepatotoxicity (ATDH) is a significant threat to tuberculosis control, and two recent studies indicated that leukocyte telomere length (LTL) might be a potential biomarker for ATDH. This study aimed to investigate the relationship between common telomere length‐related genetic variations, LTL, and risk of ATDH in Eastern Chinese antituberculosis treatment patients. A 1:4 matched case–control study was conducted among 79 ATDH cases assessed for causality using the updated RUCAM and 316 controls. LTL was determined by quantitative real‐time PCR, and nine SNPs involved in telomere biology reported by previous GWAS were assessed. Conditional logistic regression model was used to estimate the association between genotypes and risk of ATDH with odds ratios (ORs) and 95% confidence intervals (CIs). The average RUCAM score of cases was 7.1. The average LTL in cases was significantly shorter than that in controls (median = 1.239 vs. 1.481, P = 0.032). Differences in the distribution of LTL were statistically significant among three genotypes of SNP rs2736098 (CC vs. CT vs. TT, median = 1.544 vs. 1.356 vs. 1.337, P = 0.026) and rs2853677 (AA vs. AG vs. GG, median = 1.511 vs. 1.544 vs. 1.159, P = 0.005) in TERT. SNP rs7675998 in NAF1 was statistically associated with the risk of ATDH under the dominant model (adjusted OR = 1.725, 95% CI: 1.021–2.913, P = 0.042). This is the first study to investigate the relationship of LTL, common telomere length‐related variations, and risk of ATDH. SNP rs2736098 and rs2853677 in TERT were significantly associated with LTL, and SNP rs7675998 in NAF1 may be associated with ATDH in Chinese population.
Gradual stimulation of respondents' reflexivity: A research design for studying unreflexive consumers
Authors: Šimůnková Klára , Šimůnek Michal 
Published: March 2023

AbstractIn interpretive research accounts, reflexivity has been understood primarily in terms of the researcher's reflexivity, while the respondent's reflexivity has been considered only marginally. We regard this gap as critical and therefore introduce a research design for the gradual stimulation of respondents' reflexivity (GSRR), which we propose as a methodological tool for strengthening research validity. First, to frame our argumentation in the contemporary socio‐technological context, we emphasize the need to focus on the respondent's reflexivity in the onto‐epistemological conditions of the hybrid space and posthuman consumer culture, which unprecedentedly eliminate actors' abilities to monitor their actions reflexively. Second, we present and methodologically examine the GSRR as a 3‐phase sequential mixed‐method research design for stimulating respondents' reflexivity. GSRR's logic is as follows: the questionnaire captures what respondents think they are doing; the digital self‐tracking diary captures what they are doing and what they often do not acknowledge (unreflexivity); the interviews use the previous phases' data to elicit respondents' reflexivity. Third, we present examples from our research practice to demonstrate the strengthening of data validity elicited from respondents by stimulating their reflexivity. We conclude by outlining the GSRR's possible future applications and directions.
Kappaphycus alvarezii flours as an ingredient for seaweed‐enriched, rice‐based, snacks: raw algae pretreatment and physical properties of the dough and snacks
Authors: Lopes Julia Serpa , Simão Raquel da Silva , Mendes Gabrielly da Silva , Demarco Mariana , de Moraes Jaqueline Oliveira , Hayashi Leila , Laurindo João Borges , Tribuzi Giustino 
Published: March 2023

SummaryIn this work, the addition of pretreated Kappaphycus alvarezii flour to a rice‐based snack formulation was proposed as an alternative to producing algae‐enriched snacks adding value to this seaweed and improving the quality of the snacks. Dried algae were submitted to multiple washing cycles to allow the reduction of the natural salt concentration of the algae. After, algae were dried and milled to obtain flour. The flour was added in different concentrations (0%, 2%, 5%, and 10%) in the model formulation of rice‐based dough. Rice‐K. alvarezii snacks were produced by baking at 220 °C. The proximate composition of the raw and pretreated algae was determined, as well as the colour, texture, and microstructure of dough and snacks. The pretreatment efficiently allowed for a reduction of 78% of the initial content of sodium and an 85% reduction of potassium. The concentration of 5% and 10% of algae addition presented higher values of hardness and consistency of the dough and lower adhesiveness. At higher concentrations, the seaweed flour acts as a processing aid during the preparation steps of the snacks but does not influence the hardness of the final snacks. The pretreated K. alvarezii flour is an alternative for increasing the quality of rice‐based snacks while preserving the algae's potential health benefits.
Trust in hybrid human‐automated decision‐support
Authors: Kares Felix , König Cornelius J. , Bergs Richard , Protzel Clea , Langer Markus 
Published: March 2023

AbstractResearch has examined trust in humans and trust in automated decision support. Although reflecting a likely realization of decision support in high‐risk tasks such as personnel selection, trust in hybrid human‐automation teams has thus far received limited attention. In two experiments (N1 = 170,N2 = 154) we compare trust, trustworthiness, and trusting behavior for different types of decision‐support (automated, human, hybrid) across two assessment contexts (personnel selection, bonus payments). We additionally examined a possible trust violation by presenting one group of participants a preselection that included predominantly male candidates, thus reflecting possible unfair bias. Whereas fully‐automated decisions were trusted less, results suggest that trust in hybrid decision support was similar to trust in human‐only support. Trust violations were not perceived differently based on the type of support. We discuss theoretical (e.g., trust in hybrid support) and practical implications (e.g., keeping humans in the loop to prevent negative reactions).
Peritoneal closure and the processus vaginalis transection method to prevent inguinal hernia after robot‐assisted radical prostatectomy
Authors: Soma Takahiko , Fukuda Shohei , Matsuyama Yusuke , Ikeda Riko , Inoue Masaharu , Waseda Yuma , Tanaka Hajime , Yoshida Soichiro , Yokoyama Minato , Matsuoka Yoh , Fujiwara Takeo , Kageyama Yukio , Fujii Yasuhisa 
Published: March 2023

ObjectivesPostoperative inguinal hernia (IH) is one of the most common complications of radical prostatectomy (RP) including robot‐assisted RP (RARP). However, a procedure to prevent IH after RARP has not been established. We investigated the impact of processus vaginalis transection (PVT) and PVT with peritoneal closure on IH after RARP.MethodsA retrospective analysis was performed on data from patients who underwent RARP at two tertiary hospitals in Japan, where PVT with subsequent peritoneal closure was introduced after 2014. The incidence of IH for 2 years after RARP was compared among 79 patients without PVT or peritoneal closure, 232 patients with only PVT, and 325 patients with PVT and peritoneal closure. Multivariable Cox proportional hazard models that adjusted for hospital, age, history of abdominal operation, body mass index, operation time, and prostate weight were used.ResultsPostoperative IH was observed in seven (8.9%) patients without PVT or peritoneal closure, 34 (15%) patients with only PVT, and nine (2.8%) patients with PVT and peritoneal closure. Compared with patients without PVT or peritoneal closure, the incidence of IH was not different in patients with only PVT (hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.34, 2.38) and significantly lower in patients with PVT and peritoneal closure (HR 0.22, 95% CI 0.07, 0.70).ConclusionPVT with peritoneal closure may reduce the risk of postoperative IH after RARP. Future randomized controlled trials are required to confirm these findings.
Association between low‐carbohydrate diets and continuous glucose monitoring‐derived time in ranges
Authors: Osugi Keiko , Kusunoki Yoshiki , Ohigashi Mana , Kusunoki Kenji , Inoue Chikako , Inoue Maki , Takagi Ayako , Tsunoda Taku , Kadoya Manabu , Konishi Kosuke , Katsuno Tomoyuki , Koyama Hidenori ,   Hyogo Diabetes Hypoglycemia Cognition Complications (HDHCC) study group
Published: March 2023

ABSTRACTAimsLow‐carbohydrate diets have become popular in the general community. The mutual relationship between the percentage of total energy intake from carbohydrates (CHO/E), glycemic control indices, and diabetes complications remains unclear.Materials and MethodsThis cross‐sectional study included 177 patients with type 2 diabetes mellitus who regularly visited outpatient clinics. In this study, dietary questionnaires were used to assess the intake ratio of the three macronutrients, and the low‐carbohydrate‐diet score was calculated. We investigated the association between the low‐carbohydrate‐diet score, continuous glucose monitoring (CGM)‐derived short‐term glycemic control indices, and diabetes complications in patients with type 2 diabetes mellitus.ResultsThe results are presented as medians (interquartile ranges) unless otherwise stated. Hemoglobin A1c was 7.1% (6.6–7.7%), CGM‐derived time in range (TIR) was 75.3% (62.8–87.0%), body mass index (BMI) was 24.0 (22.1–26.3) kg/m2, and CHO/E was 49.8% (44.8–55.6%). BMI, triglycerides, and CGM‐derived time above range decreased significantly with increasing low‐carbohydrate‐diet scores. However, no significant association was found between the low‐carbohydrate‐diet score and glycemic control indices, including TIR, mean amplitude of glycemic excursions, and vascular complications of type 2 diabetes mellitus.ConclusionModerate‐carbohydrate diets positively impact weight control and lipid metabolism but may have a limited effect on short‐term glycemic variability in Japanese patients with type 2 diabetes mellitus.
Testing assumptions underlying cabezon (Scorpaenichthys marmoratus) otolith microstructure analysis using wild‐caught juveniles and opportunistic rearing of eggs and larvae
Authors: Wilson Megan , Sponaugle Su , Grorud‐Colvert Kirsten 
Published: March 2023

AbstractOtolith microstructure analysis provides critical biological and ecological information about the early life history of fishes. This information is particularly important to interpret and predict population dynamics for socio‐economically important fisheries species; nonetheless, several key assumptions underpin the use of otolith techniques. The authors validated the use of this analysis for cabezon (Scorpaenichthys marmoratus; Ayres, 1854), a long‐lived, large‐bodied cottid constituent of nearshore fisheries from Baja California, Mexico, to Alaska, USA. To test three critical assumptions, the authors coupled otolith and morphometric analyses from an opportunistic rearing study of cabezon eggs and larvae with a long‐term time series of juvenile cabezon field collections. The authors confirmed the daily otolith increment deposition in laboratory‐reared larvae, identified the timing of first otolith increment deposition and examined the relationship between otolith growth and somatic growth in field‐collected juveniles, validating the use of otolith microstructure analysis in biological and ecological interpretations of early life‐history traits for this species. The findings of this study also indicated that the absorption of yolk‐sac reserves, and likely the transition to exogenous feeding, plays an important role in regulating otolith increment deposition. Finally, the authors found within‐brood size‐at‐age variation, which may be an advantage for young fish in prey‐limited environments.