bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigations on the effect of natural veined calcite on the mechanical properties of limestone
Authors: Chen Qingzhi , Liu Yuanming , Teng Zhaolei , Ou Xun , Zhang Quan 
Published: July 2023

Abstract
The damage behavior of limestone rock masses containing calcite mineral filling under uniaxial compression experimental conditions is unclear, and the fracture mechanism of the rock masses needs to be further explored. In this study, uniaxial compression tests were conducted on limestone rock specimens containing veined calcite by combining acoustic emission (AE) and digital image correlation (DIC) techniques. The effects of veined calcite on the generation and development of cracks on the surface of the specimens until the formation of macroscopic penetration and the strength properties of the rock mass were analyzed. The results showed that the transversely distributed veined calcite caused significant stress concentrations in the rock specimens. The longitudinally distributed veined calcite caused cracks in the specimens or influenced the expansion path of the longitudinal principal cracks. The final damage pattern of the specimens didn’t differ significantly from that of conventional rock masses due to the presence of veined calcite. The presence of the veined calcite had effect on the uniaxial compressive capacity of the rock, but the load variation process of the specimen with time still conformed to the load variation pattern during the uniaxial compressive test of conventional rocks.
Life Cycle Assessment of an Institutional building using OpenLCA Software
Authors: Kulkarni Abhishek , Sivakumar M. V.N. 
Published: July 2023

Abstract
There is a growing recognition in the construction industry of the need to reduce the environmental impacts of buildings and construction projects. This has led to a focus on quantifying and minimizing the energy, carbon, and material footprints of buildings and construction projects, as well as implementing sustainable design strategies. The combination of tools like Building Information Modeling (BIM) and Life Cycle Assessment (LCA) is becoming more common as a way to better understand the environmental impacts and identify opportunities for improvement. By taking a proactive approach to sustainability, the construction industry can play a key role in reducing the overall environmental impact of the built environment. This study focuses on a case study of analyzing the environmental impacts of different components of a building, such as columns, beams, masonry, and slabs, in an institutional building, and determining the impacts on the environment. Masonry with fired clay bricks was found to be the component with the maximum environmental impacts, and different alternative materials for replacement, such as fly ash bricks, were assessed in Open-LCA software using the Ecoinvent database. The environmental impacts of fired clay bricks and fly ash bricks were compared, and the results of the reduction in environmental impacts are presented.
Promising Use of Filgotinib in Patients Affected by Systemic Sclerosis: Preliminary Data From a Monocentric, Prospective, Open-label Study
Authors: Sandri Gilda , de Pinto Marco , Spinella Amelia , Macripò Pierluca , Amati Gabriele , Lumetti Federica , Secchi Ottavio , Guerra Anna , Giuggioli Dilia 
Published: July 2023

Abstract
Objective
To assess the efficacy and safety of Filgotinib for the management of cutaneous, visceral and articular involvement in patients affected by Systemic sclerosis.
Methods
5 patients affected by SSc referring to the Scleroderma Units of Modena and Reggio Emilia between October 2021 and February 2023, were enrolled.
Patients received 200 mg of Filgotinib once daily for a period of 52 weeks. Skin, articular and visceral organ involvement were evaluated at the baseline and every 12 weeks after the start of the treatment.
Results
A significant improvement of articular involvement was seen at 12th week. All patients confirmed a significant amelioration in articular involvement at 52th week, with a significant reduction in TJ, SDAI/CDAI, DAS28-CRP. PDUS performed after 24 and 52 weeks of treatment supported the remission.
A significant decrease of mRSS, improvement of other skin manifestations and a stabilization of ILD, assessed through HRCT and PFTs, were noticed in patients with dcSSc.
The 2 patients with dsSSC showed a clinical improvement assessed using the CRISS score.
No drug-related side effects were recorded and neither patients discontinued the treatment. No deaths were reported.
Conclusion
Filgotinib was safe, effective and well tolerated in the treatment of articular and visceral involvement in patients affected by SSc.
Unlocking the Antioxidant Potential of White Tea and Osmanthus Flower: A Novel Polyphenol Liquid Preparation and Its Impact on KM Mice and Their Offspring
Authors: Wang Yisen , Xu Jiaqi , Fan Ziluan , Zhou Xun , Wang Zhenyu , Zhang Hua 
Published: July 2023

Abstract
Scope: White tea rich in polyphenols has excellent antioxidant effect, but there is still some space for research and development of its functional application. In this study, we formulated a liquid polyphenol preparation derived from white tea and osmanthus flower(wtofLPP), which exhibited rich antioxidant content and desirable rheological properties.
Methods and results: The average particle size of wtofLPP was determined using a nanoparticle analyzer to assess the rheological properties of wtofLPP. The antioxidant performances in vitro were evaluated by in vitro antioxidant method. Notably, the wtofLPP substantially enhanced superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities in KM mice and their offspring. Furthermore, it reduced malondialdehyde (MDA) levels, extended swimming time, and significantly increased small molecules such as glutathione (GSH), ceruloplasmin, and Vitamin E, which are known to exert antioxidant activities. The preparation also elevated liver glycogen levels, while decreasing lactic acid and urea nitrogen concentrations. Oxidative damage poses significant health risks, leading to alterations in physiological markers and potentially causing severe epigenetic effects on offspring.
Conclusion: Collectively, these findings indicated that the liquid polyphenol formulation(wtofLPP) protected against fatigue-induced oxidative damage, offering potential health benefits for both the parent generation and their progeny.
Disease burden and costs associated with multiple sclerosis in China: A cross-sectional analysis of nationwide survey data
Authors: Jia Yusheng , Qiao Xuanqi , Zhao Jin , Li Hainan , Hu Shanlian , Hu Min 
Published: July 2023

Abstract
Background
Multiple sclerosis (MS) imposes a huge burden on patients, not only physically, due to progressive disability, but also financially, due to reduced productivity and high utilization of healthcare resources. Little is known about the costs associated with MS for patients in China. This study aimed to estimate the disease burden of MS in China and the economic impact of MS and its association with disability severity, thereby providing empirical data to inform public health decision-making.
Methods
This was a retrospective, cross-sectional study using a self-reported online survey. Data were collected from MS patients including demographic information, employment status, health-related quality of life, resource utilization, and associated costs. The severity of the disability status of MS patients was identified by a proxy question for the Expanded Disability Status Scale (EDSS). Regression analysis was applied to estimate the association between costs and disease severity.
Results
A total of 477 MS patients were included in the study. The mean age was 34.5 years, and 65.6% were female. The employment rate was 50.3%. The average total annual costs for an MS patient were approximately 168,228 CNY (23,720 USD) in China. The mean utility value was estimated at 0.808 for patients with EDSS < 4, 0.437 at EDSS 4–6, and 0.017 at EDSS > 6. Total annual costs of MS were 154,673 CNY (21,809 USD) at EDSS < 4, 187,038 CNY (26,372 USD) at EDSS 4–6, and 235,390 CNY (33,190 USD) at EDSS > 6. This study further found a significant association between disability severity and indirect costs due to MS.
Conclusions
Our findings identified severe disease burden and costs among MS patients in China. Higher costs were imposed on MS patients as the severity of disability increased, and the increase in the economic burden of MS was mainly driven by a dramatic increase in indirect costs. This study highlights the importance of slowing the progression of MS to reduce indirect costs of MS patients and provides empirical data for further policy review and reform.
The Effects Of Injectable Platelet-Rich Fibrin Application On Wound Healing Following Gingivectomy and Gingivoplasty Operations: single-blind, randomized controlled, prospective clinical study
Authors: Bahar Şeyma Çardakcı , Karakan Nebi C. , Vurmaz Ayhan 
Published: July 2023

Abstract
Objectives
The study aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) applications on early wound healing after gingivectomy and gingivoplasty surgery.
Materials and Methods
In this study, gingivectomy and gingivoplasty surgeries were performed on two groups. I-PRF (n = 23) was applied and compared with control group (n = 23). The surgical areas were stained with Mira-2 tone and evaluated in the ImageJ program. Wound healing was evaluated by using the Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index. Vascular endothelial growth factor (VEGF) and fibroblast growth factor 10 (FGF-10) concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA). The seven-day Visual Analog Scale was used to assess pain level.
Results
The amount of staining with Mira-2 tone was found to be significantly higher in the control group than in the test group on days 3, 7, and 14. LTH index values ​​of the control group were significantly lower than the test group, and MMS scale values ​​were significantly higher than those of the test group. VEGF values of the control group at baseline, week 2, and week 3 were significantly higher than the test group. In weeks 2 and 3, FGF-10 values were found to be significantly higher in the control group than in the test group.
Conclusions
I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.
Clinical Relevance:
Platelet concentrates such as i-PRF accelerate wound healing and contribute to the patient’s comfort and quality of life.
Development of an early alert model for pandemic situations in Germany
Authors: Wang Danqi , Lentzen Manuel , Botz Jonas , Valderrama Diego , Deplante Lucille , Perrio Jules , Génin Marie , Thommes Edward , Coudeville Laurent , Fröhlich Holger 
Published: July 2023

Abstract
The COVID-19 pandemic has pointed out the need for new technical approaches to increase the preparedness of healthcare systems. One important measure is to develop innovative early warning systems. Along those lines we developed a machine learning (ML) approach using Google Trends and Twitter data for Germany. As a use case we evaluated our models using COVID-19 surveillance data between March 2020 and June 2022. In conclusion we found that a long-short-term memory (LSTM) jointly trained on COVID-19 symptoms related Google Trends and Twitter data was able to accurately forecast up-trends in confirmed cases and hospitalization rates 14 days ahead. In both cases, F1 scores were above 98% and 97%, respectively, hence demonstrating the potential of using digital traces for building an early alert system for pandemics in Germany.
Annealing Effect on Mechanical and Tribological behaviour of Nanoscale Mechanics of Thin Layer Metallic Glasses for Engineering Material Applications
Authors: Muhabie Adem Ali , Girma Wubshet Mekonnen 
Published: July 2023

Abstract
A new and unique alloy formulation design strategies has been developed in order to fabricate thin layered metallic glasses (TFMG) with superior fracture resistance and low coefficient of friction (COF) during nano-scraching test. Due to the outstanding properties, TFMG could be applied for different uses uch as surface coating, biomedical, bio implant, electronic devices, spacecraft and railway, all of which need surface fracture resistance. The fabricated Zr-based metallic glass having the composition of Zr60Cu25Al5Ag5Ni5 (at.%) was annealed for 10, 30, and 60 min below the glass transition temperature. Nanoindentation and nanoscratch tests were used to investigate mechanical and nanotribological properties. Atomic force microscopy (AFM) was used to examine the surface morphology and microstructures. The annealing effect and applied forces change over the chemical structure and stability, morphological change, elastic modulus, hardness, wear rate, and coefficient of friction of the samples were systematically investigated. The nano-indentation data indicated that the hardness and average elastic modulus of the samples increased with increasing annealing time, compared with those of the as-cast MG. More intriguingly, the coefficient of friction and wear rate decreases when the annealing time increases compared to as-cast MG. Furthermore, the continuous wear process, wear depth, wear track volume, and contact area decreases with increasing annealing time, as a result of the improvement of the mechanical and tribological properties of the thin-layered MGs. This study can be a reference to the design protocol to prepare novel a-MGs, which have outstanding mechanical and tribological behavior for engineering material applications.
Past Trends and Future Directions on Green Human Resource Management and Green Innovation: A Bibliometric Analysis (2013-2023)
Authors: Faheem Asra , Nawaz Zubair , Ahmed Masood , Haddad Hossam 
Published: July 2023

Abstract
This study aims to cover the research trends on the published literature of Green Human Resource Management and Green Innovation. In addition, we explored the topic's research trends in the context of what, how, when, where, and by whom. The study used the Scopus Data base to retrieve bibliometric data from year 2013 to March 2023. Using preferred reporting items for systematic reviews and metanalysis (PRIZMA) approach, 47 published articles were finalized from the data set of 312 articles. The software VOSviewer is used to analyse the bibliometric data and insights are presented regarding past trends and future directions. Results indicate that there is an upward surge of research on the topic in recent years. Moreover, this study summarizes the past trends, contribution of major authors, institutions and international collaborations. Furthermore, this study presents the summary of findings of top cited papers and maps out noticeable future directions for the researchers.
The diagnostic value of DCE-MRI quantitative analysis combined with PI-RADS v2.1 in prostate cancer
Authors: Zhang Wei , Wang Wei , Huang Xing-hong 
Published: July 2023

Abstract
Background: To explore the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters combined with the prostate imaging report and data system version 2.1 (PI-RADS v2.1) for prostate cancer (PCa).
Methods: Retrospective collection of clinical data from patients with PCa who underwent DCE-MRI at Tongji Hospital Affiliated to Tongji University from June 2018 to January 2020, along with pathological results. Quantitative parameter (Ktrans, Kep and Ve) histograms were obtained through Siemens post-processing workstations. Receiver operating curve (ROC) were used to determine the optimal quantitative parameters, and logistic regression was utilized to establish a joint diagnostic model of quantitative parameters and PI-RADS score for patients with PCa.
Results: The Ktrans and Kep (mean, 25th, 50th, and 75th) and Ve (25th) in the PCa group were higher than those in the non-tumor group (P<0.05). ROC results showed Ktrans 25th and Kep 50th had higher AUC, sensitivity and specificity for the diagnosis of PCa. Logistic regression analysis indicated the combined application of Ktrans 25th, Kep 50th and PI-RADS has higher application value in the diagnosis and invasiveness for PCa (P<0.05).
Conclusions: The combined diagnostic model of Ktrans 25th, Kep 50th and PI-RADS have higher diagnostic efficiency in detecting PCa.
Factors Associated with Patient Adherence to Biofeedback Therapy Referral for Migraine: An Observational Study
Authors: Minen Mia T. , George Alexis , Cuneo Ami Z. 
Published: July 2023

Abstract
Background
Biofeedback has Grade A evidence for the treatment of migraine, yet few studies have examined the factors associated with patients' decisions to pursue biofeedback treatment recommendations.
Objective
To examine reasons for adherence or non-adherence to referral to biofeedback therapy.
Methods
Patients with migraine who had been referred for biofeedback by a headache specialist/behavioral neurologist were interviewed in person or via Webex. Patients completed a questionnaire addressing demographics and questions related to their headache histories. At one month, patients were asked if they had pursued the recommendation for biofeedback therapy, their reasons for their decision, and their impressions about biofeedback for those who pursued it.
Results
Of the nearly two-thirds (65%; 33/51) of patients who responded at one month, less than half (45%, 15/33) had contacted biofeedback providers, and only 18% (6/33) were able to participate in biofeedback. Common themes emerged in patients who did not pursue biofeedback, including feeling that they did not have time, endorsing financial obstacles, including treatment cost and/or insurance coverage, and finding it too difficult to schedule an appointment due to limited provider availability. When asked about their preference between a physical therapist or psychologist as a biofeedback provider, responses were mixed; many patients indicated no preference so long as they took insurance and/or were experienced, while others indicated a specific preference for a physical therapist or psychologist due to familiarity, or prior experiences with that kind of provider.
Conclusion
Patients with migraine referred for biofeedback therapy face numerous obstacles to pursuing treatment.
Clinical characteristics and prognostic impact of immune checkpoint inhibitor-associated myocarditis in advanced non-small cell lung cancer
Authors: Xu Lan , Xu Manyi , Sun Wei , Zhang Weiping , Song Zhengbo 
Published: July 2023

Abstract
Background: Myocarditis is a rare immune-related adverse events (irAEs) with high mortality rates, with few reports on its clinical characteristics and prognostic impact. This study designed to explore the associations between cardiac parameters and outcomes of myocarditis in advanced non-small cell lung cancer (NSCLC) who treated with immune checkpoint inhibitor (ICI).
Methods: Fourteen patients diagnosed with ICI-associated myocarditis by clinicians were admitted to the study analysis. By Cox univariate and multivariate survival analyses, potential risk factors for the development of severe myocarditis were identified. Survival analysis was also performed to explore the prognosis of patients with myocarditis.
Results: Among patients with myocarditis, higher B-type natriuretic peptide (BNP) levels (P=0.04) and conduction block (P=0.03) were associated with progression to severe myocarditis.In addition, high lactate dehydrogenase (LHD)levels (P=0.04) and myocarditis onset within 2 months (P=0.02) were prognostic factors of severe myocarditis. The median progression-free survival (PFS) time and median overall survival (OS) time for all patients were 5.9 months and 18.5 months, respectively. However, there were no statistical differences between mild and severe cohorts in terms of PFS and OS (PFS: 4.5 vs. 8.5 months, P=0.17; OS: 21.3 vs. 18.5months, P=0.36). And we found that the earlier occurrence of myocarditis, worse PFS prognosis (4.5 months vs. 10.5 months, P=0.008), while no difference in OS (18.5 months vs. 21.3 months, P=0.35).
Conclusion: Compared to mild myocarditis, severe myocarditis presented with higher BNP levels and cardiac conduction abnormalities. In addition, patients with mild and early myocarditis tended to have better survival rates.
GWAS in two Saudi Myocardial Infarction Cohorts and European based studies reveal dozens of concordant signals
Authors: AlAli Amein , Al-Rubaish Abdullah , Alali Rudaynah , Almansori Mohammed , Aljumaan Mohammed , Alshehri Abdullah , Al-Madan Mohammed , Vatte ChittiBabu , Verma Shefali , Cherlin Tess , Young Sylvia , Morahan Grant , Koeleman Bobby , Keating Brendan 
Published: July 2023

Abstract
Genome-wide association studies (GWAS) have yielded significant insights into the genetic architecture of MI although studies in non-European are still lacking. Saudi Arabian cohorts offers the opportunity for discovery of novel genetic variants impacting disease risk due to the high rate of consanguinity. GWG imputation and GWAS followed by meta-analysis was performed on two independent Saudi Arabian studies comprising 3,950 MI cases and 2,324 non-MI controls. Meta-analyses were then performed with the two Saudi MI studies and the CardioGRAMplusC4D and the UK BioBank GWAS as controls Meta-analyses of the two Saudi MI studies resulted in 17 SNPs reaching genome-wide significance. Meta-analyses of all 4 studies revealed 66 loci reaching genome-wide significance levels of p < 5 x 10− 8. All of these variants with the exception of rs2764203 have previously been reported as MI associated loci or are in high linkage disequilibrium with known loci. One SNP association in Shisa family member 5 (SHISA5) (rs11707229), is evident at a much higher frequency in Saudi MI populations (> 12% MAF). In conclusion, our results replicated many MI associations, whereas in Saudi only GWAS (meta-analyses) several new loci were implicated that would require future studies for validation and functional analyses.
Parameter constraints from shadows of Kerr-Newman-dS black holes with cloud strings and quintessence
Authors: Cao Wenfu , Liu Wenfang , Wu Xin 
Published: July 2023

Abstract
The motion of photons around the Kerr-Newman-dS black hole surrounded by quintessence and a cloud of strings is investigated. The existence of the Carter constant leads to that of unstable circular photon orbits on a two-dimensional plane not limited to the equatorial plane and unstable spherical photon orbits in the three-dimensional space. These circular or spherical photon orbits can determine two impact parameters, which are used to calculate black hole shadows. For the case of a spherically symmetric nonrotating black hole, the black hole shadow is circular and its size is independent of an observation angle and a plane on which a circular photon orbit exists. The shadow sizes are significantly influenced by the parameters involving the cloud of strings, quintessence parameter, magnitude of quintessential state parameter , and cosmological constant. When the black hole is spinning and axially symmetric, the black hole shadow is dependent on the observation angle. The effects of the parameters excluding the spin parameter on the sizes of black hole shadows in the rotating case are similar to those in the nonrotating case. Based on the Event Horizon Telescope observations of M87*, the constraint of the curvature radius is used to constrain these parameters. For slowly rotating black holes, the allowed regions of the parameters including the cosmological constant are given.