bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optogenetics 2.0: challenges and solutions towards a quantitative probing of neural circuits
Authors: Altahini Saleh , Arnoux Isabelle , Stroh Albrecht 
Published: August 2023

Abstract
To exploit the full potential of optogenetics, we need to titrate and tailor optogenetic methods to emulate naturalistic circuit function. For that, the following prerequisites need to be met: first, we need to target opsin expression not only to genetically defined neurons per se, but to specifically target a functional node. Second, we need to assess the scope of optogenetic modulation, i.e. the fraction of optogenetically modulated neurons. Third, we need to integrate optogenetic control in a closed loop setting. Fourth, we need to further safe and stable gene expression and light delivery to bring optogenetics to the clinics. Here, we review these concepts for the human and rodent brain.
Digital consumer behaviour: insights into the perceptions of late adolescents’ consumption of digital media on cognitive health
Authors: Pinto Suzan Deenal , Anakkathil Anil Malavika 
Published: August 2023

Abstract

Objectives
Digital media has become an indispensable facet of adolescents’ everyday lives, playing a crucial role in their daily routines, encompassing various activities such as accessing information, accomplishing academic tasks, and facilitating interpersonal communication. Literature evidence on the effects of digital media on cognitive health is bi-directional, having both positive and negative impacts. The present research aimed to explore the perceptions of digital media consumption on cognitive health in late adolescents between the age of 17 and 21 years.

Methods
A self-reported online survey was administered to 173 adolescents, and the data were analysed using statistical software (SPSS 17).

Results
The findings revealed that some late adolescents recognize the importance of cognition in their daily activities and health, particularly for activities focused on cognitive, academic, personal, and social skills. Mobile phones, laptops, and television were the most commonly preferred gadgets, while e-pads, Alexa, smartwatches, Kindle, tablets, and play stations were less preferred. Interestingly, a high proportion of participants reported neutral perceptions of digital media’s influence on cognitive health, highlighting the need to create awareness and educate late adolescents on healthy digital media consumption.

Conclusions
The findings hold significant implications for the development of comprehensive guidelines and evidence-based recommendations for digital media usage among late adolescents. Additionally, the research sheds light on the strategies adopted by adolescents to regulate and optimize their consumption of digital media, thereby providing valuable insights into effective practices and potential areas for improvement.
Dynamic development of cohesive devices in English as a second language writing
Authors: Abdi Tabari Mahmoud , Wind Attila M. 
Published: August 2023

Abstract
The dearth of research examining the progression of cohesion in L2 writing through a time-series research design is evident. Therefore, the current study employs the Complex Dynamic Systems Theory to explore the evolution of cohesive devices in L2 writing. Thirty advanced-level L2 writers from a US university participated over a semester, providing 210 written samples at seven measurement points. Analysis of these samples, utilizing 40 cohesion indices from the Tool for the Automatic Analysis of Cohesion, revealed significant improvement in eight cohesion indices (three local, four global, and one text cohesion indices) with large effect sizes. However, time-series analyses indicated nonlinear trends and variability. Additionally, a positive association was found between two local cohesion indices (lexical and semantic overlap) at the initial and final measurement points. The findings demonstrate the multifaceted developmental trajectories and complexities evident in L2 learners’ approaches and carry important implications for L2 writing instruction and assessment.
Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia
Authors: Li Qi , Cheng Yujing , Chen Wanlu , Wang Ying , Dai Run , Yang Xin 
Published: August 2023

Abstract
Phosphodiesterase 4D interacting protein (PDE4DIP) interacts with cAMP-specific phosphodiesterase 4D and its abnormal expression promotes the development of hematological malignancies, breast cancer, and pineal cell carcinoma. However, there is currently no systematic pan-cancer analysis of the association between PDE4DIP and various cancers. Thus, this study aimed to elucidate the potential functions of PDE4DIP in various cancers. Based on the multiple public databases and online websites, we conducted comprehensive analyses for PDE4DIP in various cancers, including differential expression, prognosis, genetic variation, DNA methylation, and immunity. We thoroughly analyzed the specific role of PDE4DIP in acute myeloid leukemia (LAML). The results indicated that there were differences in PDE4DIP expression in cancers, and in kidney chromophobe, LAML, pheochromocytoma and paraganglioma, thymoma, and uveal melanoma, PDE4DIP had potential prognostic value. PDE4DIP expression was also correlated with genetic variation, DNA methylation, immune cell infiltration, and immune-related genes in cancers. Functional enrichment analysis showed that PDE4DIP was mainly related to immune-related pathways in cancers, and in LAML, PDE4DIP was mainly related to immunoglobulin complexes, T-cell receptor complexes, and immune response regulatory signaling pathways. Our study systematically revealed for the first time the potential prognostic and immunotherapeutic value of PDE4DIP in various cancers, including LAML.
Mild solution in the α-norm for some partial integrodifferential equations involving a nonlocal condition
Authors: El Matloub Jaouad , Ezzinbi Khalil 
Published: August 2023

Abstract
In this work, we investigate the existence of mild solutions in the

α

\alpha

-norm for a class of nonlocal integrodifferential equations. We employ the theory of resolvent operators introduced by R. Grimmer. The Leray-Schauder alternative is the principal working tool for our analysis.
Switchable dual-mode nanolaser: mastering emission and invisibility through phase transition materials
Authors: Lepeshov Sergey , Vyshnevyy Andrey , Krasnok Alex 
Published: August 2023

Abstract
The principle of detailed balance states that objects efficiently emitting radiation at a specific wavelength also efficiently absorb radiation at the same wavelength. This principle presents challenges for the design and performance of photonic devices, including solar cells, nanoantennas, and lasers. A design that successfully integrates the properties of an efficient emitter in one state and invisibility in another state is essential for various applications. In this work, we propose a novel nanolaser design based on a semiconductor nanoparticle with gain enveloped by a phase transition material that enables switching between lasing and cloaking (nonscattering) states at the same operating frequency without modifying the pumping conditions. We thoroughly investigate the operational characteristics of the nanolaser to ensure optimal performance. Our nanolaser design can function with both optical and electric pumping and exhibits the features of a thresholdless laser due to its high beta-factor and strong Purcell enhancement in the tightly confined Mie resonance mode. Additionally, we develop a reconfigurable metasurface comprising lasing-cloaking metaatoms capable of transitioning from lasing to a nonscattering state in a fully reversible manner.
An Example of Geographic Network Analysis: The Case Study of the Fortore Valley (Molise and Apulia, Italy)
Authors: De Simone Claudio Sossio 
Published: August 2023

Abstract
Today, the Fortore River is the geographic and administrative boundary between the regions of Molise and Apulia. In the past decade, scholars have debated Fortore’s role during the pre-Roman and Roman periods, specifically focusing on how this physical boundary may have influenced the interaction and connectivity between Samnium (modern-day Molise) and Daunia (modern-day northern Apulia). Both ancient literary sources and archaeological finds indicate the situation is complicated, and it is challenging to locate the geographical and cultural borders, especially in the pre-Roman period. This article suggests a model to understand the past interaction between the two modern-day areas of Macchia Valfortore (Molise) and Carlantino (Apulia). These sites were in the proximity of the Fortore River, and an investigation of material culture in both locations revealed a complex and diverse society between the sixth century BC and the first century BC. The small-scale spatial networks constructed help to explain the interchange dynamics between the two districts and, furthermore, how each of them related to the ancient road system. The case study demonstrates, moreover, how a not conventional archaeological approach may also highlight the prominence of river connections for economic and social development.
Ethical Issues of Human Information Behaviour and Human Information Interactions
Authors: Steinerová Jela 
Published: August 2023

Abstract
The objectives of the study are to determine the main ethical factors related to human information interactions. The main research question was: What is the perception of ethical issues of information work and future topics of information ethics in digital environment? A brief analysis of related ethical issues of information is presented. The main applied methodology was a Delphi study on information ethics with selected experts from Slovakia and Czech Republic. The data were analysed with the use of mixed methods of discourse and content analyses and conceptual modelling. We present results of the discourse analyses (first round, 19 experts; discussion, 6 experts). Results are interpreted with regard to the ethical issues of work with digital information, main ethical dilemmas of the use of advanced technologies, and values of information. Results are visualised in three conceptual maps. A final conceptual model represents the epistemic consensus of experts, including social and cultural rules, value tensions between man and technologies, and utility, truth, and objectivity of information. We propose to include the identified ethical factors into models of human information behaviour. Recommendations for practice focus on value-sensitive design of digital services and products in the intercultural contexts of information literacy, education, science, workplaces, and everyday information use.
Recent development in the formation and surface modification of cellulose-bead nanocomposites as adsorbents for water purification: a comprehensive review
Authors: Ivbanikaro Anna E. , Okonkwo Jonathan O. , Sadiku Emmanuel R. , Maepa Charity E. 
Published: August 2023

Abstract
Water pollution is an issue of global concern that demands effective and sustainable solutions through water purification. Adsorption is a popular method for water treatment because it is inexpensive and has a high performance rate. Although commercial activated carbon is the generally preferred adsorbent for adsorption, its widespread use is affected by the high cost and challenges encountered during column adsorption. Biopolymers like cellulose and its derivatives have the potential to replace expensive adsorbents due to their unique characteristics. In recent years, cellulose-bead nanocomposites have gained significant attention as promising adsorbents due to their ability to circumvent the challenges encountered when using powdered adsorbents. To fabricate cellulose beads, cellulose fiber is separated from its source, dissolved in appropriate solvents, shaped into spherical particles and subsequently modified (via esterification, oxidation, crosslinking agents, etc.) to improve its adsorption capacity. This comprehensive review paper presents a detailed analysis of the recent development in the formation and surface modification of 3-D structured cellulose nanocomposites. The outcome of this review on modified cellulose-bead demonstrates their successful fabrication and high adsorption capacities for different contaminants. It is anticipated that cellulose beads, as a bio-adsorbent in industrial settings, will be a low-cost alternative to the more expensive adsorbents shortly.
Circular plastics technologies: open loop recycling of waste plastics into new chemicals
Authors: Knauer Katrina , Lee Minjung 
Published: August 2023

Abstract
Open-loop recycling is any recycling process where the recycled materials are converted into new raw materials, often of higher value than the parent monomers. Typically, materials recycled through open-loop recycling go on to be used for purposes different from their former, pre-recycled purpose. This means that the input into the recycling process is converted to a new chemical building block, which can be used as an input into another manufacturing process. Open-loop recycling processes usually involve processing various types of products of similar material makeup and change the properties of the material itself (through heat, chemical reactions, or physical crushing). This chapter will highlight promising pathways for upcycling of various plastic waste streams into new applications via open loop chemical and biological recycling processes.
Biopolymeric conjugation with food additives
Authors: Kaur Gurleen , Thakur Babita , Gill Ruth , Kaur Rajinder , Kaur Sukhminderjit 
Published: August 2023

Abstract
In the contemporary day and age, the usage of food additives has predominantly expanded because of accelerated processed food’s requirement. Food additives comprises of preservatives, color dye, flavors, textural additives, antimicrobial agents, antioxidants, anti-caking additives, anti-foaming agents, emulsifiers and nutritional additives. Although, food additives assist in proving textural benefits, increased shelf life, color addition and flavor enhancer but limitations are also associated with the use of food additives such as reduction in shelf life, toxic behavior, reduced stability and controlled target release issues. Biopolymers, dominantly pervasive macromolecules are the prominent class of utilitarian materials which are convenient for valuable applications. Across the globe, professionals and researchers are highly interested in research on biopolymers due to its biocompatible and biodegradable prospect. The two major classifications of biopolymers include proteins and polysaccharides. Different types of biopolymers can also work as fat replacer and therefore offer prevention from coronary disease, obesity as well as diabetes. Food industry has been highly promoted and benefited from the use of biopolymers. The employment of biopolymers solves the issues related to food additives consumption. Therefore, this particular chapter elucidates about the biopolymeric conjugation with food additives for a perfect food design, importance of biopolymers and application of biopolymers in association with food additives.
In-service load calculation surrogate models for high-pressure turbine blade life digital twin
Authors: Li Chunhua , Sun Jianzhong , Wang Bowen , Nian Jinchen 
Published: August 2023

Abstract
There are developed methods for high-pressure turbine (HPT) blade loads and remaining useful life (RUL) prediction; however, they are ineffective and time-consuming for in-service HPT blades under actual operating conditions. Hence, it is necessary to use an acceptable computational effort to predict the HPT blade’s load and in-service lifetime. Drawing from the idea of the usage-based life (UBL) prediction method, this paper first proposes a framework for the life digital twin (LDT) to characterize and track the in-service life consumption of the HPT blades under actual operating conditions. The second work mainly focuses on developing the steady-state and transient load calculation surrogate models for the HPT blade’s LDT. Using the developed surrogate models, it can now calculate the steady-state and transient loads of the HPT blade in an acceptable time with the necessary accuracy. The proposed approach is demonstrated on an HPT blade of a typical commercial turbofan engine. Because the operating load of the HPT blade severely affects its in-service lifetime, the application of this approach enables the construction of an LDT of the HPT blade. It can reduce the uncertainty and variability associated with the in-service life prediction of the HPT blade under actual operating conditions.
Numerical analysis on the effect of passive control geometry in supersonic jet mixing enhancement
Authors: Subramani Nithya , M Sangeetha , Gajapathy Gowtham 
Published: August 2023

Abstract
This paper presents the numerical analysis of a convergent-divergent circular nozzle with the exit Mach number of 1.69 with and without passive control at the exit. The passive control method opted for this analysis was inward and outward ascending triangular protrusion. This paper explores the influence of the passive control geometry and its blockage area concerning the nozzle exit. The nozzle pressure ratio (NPR) used for carrying out the flow analysis were 3, 4.932, and 6. Two different inward and outward protrusions were used with a height of 1.5 mm and 3 mm. From the results, the potential core length of the protrusion 1.5 mm height was not much changed in the both outward and inward cases. But when the height of the protrusion was increased to 3 mm, there was a noticeable core length reduction at all NPR but with different cases. At the NPR of 6, the potential core length of the inward protrusions 3 mm was reduced by 44 % compared to the plain CD nozzle.
Comparative Justice Accountability of Samen Leven Actors in Indonesia and Malaysia
Authors: Saputri Atha Difa , Julianto Ricky 
Published: August 2023

The practice of samen leven or cohabitation is a violation of the religious and cultural norms of Indonesian society, but semen leven is increasingly common in today's modern society, especially in Indonesia and Malaysia. The rise of this cohabitation shows a decline in moral and religious values ​​in society. Discussion in this article will cover various regulations related to semen leven or (cohabitation) included in the previous or new Criminal Code and discuss various polemics around them. Then it will also be discussed how legal, religious, and social perspectives are on the practice of semen leven and how the sanctions are imposed. The purpose of this paper is to understand the legal views governing the act of cohabitation as well as efforts to deal with the problem of samen leven in Indonesia by comparing and analyzing a comparison of the two views of the legal system that applies between Malaysia and Indonesia towards the practice of cohabitation. The approach research method that we use is carried out through a literature review and normative juridical methods using primary sources in this study in the form of the Criminal Code, Law Number 1 of 1974 concerning marriage, the 1984 Islamic Family Law concerning marriage and divorce in Malaysia. Secondary sources in the form of all legal publications, including textbooks, legal dictionaries, legal journals, legal articles, and comments on court decisions.
KEYWORDS: Samen Leven, Cohabitation, Legal Comparasion.
BCR::ABL1 negative myeloproliferative neoplasms: A review focused on essential thrombocythemia and polycythemia vera
Authors: Khodier Malaz , Gadó Klára 
Published: August 2023

AbstractThe classical myeloproliferative neoplasms are divided into chronic myeloid leukemia, and the Philadelphia negative polycythemia vera, essential thrombocythemia and primary myelofibrosis. These are heterogenous diseases, originating from the clonal proliferation of myeloid stem cells, resulting in increased mature cell numbers in one or more myeloid lineages. The most commonly seen mutations in the Philadelphia negative myeloproliferative neoplasms include those in Janus kinase, myeloproliferative leukemia protein and the calreticulin genes. Philadelphia negative myeloproliferative neoplasms occur infrequently, with a combined annual incidence of 2.58 per 100,000. There are many overlapping symptoms of Philadelphia negative MPNs, such as fatigue, night sweats, hepatosplenomegaly and circulatory symptoms due to increased cell numbers. Total Symptom Score of the MPN Symptom Assessment Form is used to assess symptom burden on patients. The most worrisome complications are thrombo-hemorrhagic events, and risk stratification is especially important as treatment of disease is based on their category. Phlebotomy and aspirin are the mainstay of treatment in low-risk polycythemia vera and essential thrombocythemia patients, whereas high-risk disease calls for additional cytoreduction, usually with hydroxyurea.
Serviço Social, Assistência Social e Proteção Social: Entrevista com a Professora Ivone Pereira da Silva
Authors: Silva Ivone Pereira , Alves Alan Loiola , Santos Rosemeire 
Published: August 2023

Ivone Pereira da Silva is a Social Worker, graduated in Social Work - Faculdades Metropolitanas Unidas (1978). Master in Social Work from the Pontifical Catholic University of São Paulo (1995). She worked as a Social Worker at the São Paulo City Hall for over 30 years. She has experience in the research area, with emphasis on the themes: home care, family caregiver, social assistance and dependent elderly. She is dedicated to delving into social assistance policy and research in this area. She has teaching experience in graduation and specialization in Social Work. She taught for 19 years in higher education. She is currently retired.
Using LLM Models and Explainable ML to Analyse Biomarkers at Single Cell Level for Improved Understanding of Diseases
Authors: Elsborg Jonas , Salvatore Marco 
Published: August 2023

Single-cell RNA sequencing (scRNA-seq) technology has significantly advanced our understanding of
the diversity of cells and how this diversity is implicated in diseases. Yet, translating these findings across
various scRNA-seq datasets poses challenges due to technical variability and dataset-specific biases. To
overcome this, we present a novel approach that employs both an LLM-based framework and explainable
machine learning to facilitate generalization across single-cell datasets and identify gene signatures to
capture disease-driven transcriptional changes.
Our approach uses scBERT, which harnesses shared transcriptomic features among cell types to establish consistent cell-type annotations across multiple scRNA-seq datasets. Additionally, we employ a
symbolic regression algorithm to pinpoint highly relevant yet minimally redundant models and features
for inferring a cell type’s disease state based on its transcriptomic profile. We ascertain the versatility
of these cell-specific gene signatures across datasets, showcasing their resilience as molecular markers to pinpoint and characterize disease-associated cell types.
Validation is carried out using four publicly available scRNA-seq datasets from both healthy individuals
and those suffering from ulcerative colitis (UC). This demonstrates our approach’s efficacy in
bridging disparities specific to different datasets, fostering comparative analyses. Notably, the simplicity
and symbolic nature of the retrieved gene signatures facilitate their interpretability, allowing us to
elucidate underlying molecular disease mechanisms using these models.