bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical modeling, seismic fragility, and correlation issues for groups of spherical pressure vessels
Authors: Karaferis N. D. , Melissianos V. E. , Vamvatsikos D. 
Published: August 2023

AbstractA roadmap is outlined for determining comprehensive seismic fragility curves for (single or groups of) spherical pressure vessel structures commonly found in oil refineries. The developed modeling techniques aim to strike a balance between accuracy and computational efficiency, with a focus on capturing the most pertinent failure modes relevant to these structural types. First, a set of “partial” fragilities is determined based on each vessel’s fill ratio, as the response varies substantially depending on the amount of liquid content. Considering that a seismic assessment process invariably involves simultaneous consideration of such partial fragilities, a Monte Carlo-based approach is employed for their combination. The results naturally depend on the level of correlation employed, but can be almost perfectly matched by simpler analytical methods in the edge cases of full and zero correlation.
Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome
Authors: Díaz Catalina , Aragón Natalia , Lopez-Medina Eduardo , Arango Maria Cristina , Dávalos Diana , Contreras-Rengifo Adolfo 
Published: August 2023

Abstract
Objective
Zika virus infection has been associated to congenital zika syndrome (CZS) in newborns and is characterized by microcephaly, central/axial motor and sensory dysfunction, dysphagia among other previously described severe health complications. CZS is usually diagnosed postpartum by evident/apparent neural development problems. Although there are some reports of craniofacial/dentition development in CZS, several clinical oral aspects are still unknown. This study describes some structural and functional characteristics of facial and cranial growth and deciduous dentition in CZS-affected children.

Material and methods
Some cranial, facial and dental characteristics were determined in 14 children with CZS aged 3–5 years and compared them against 12 apparently healthy children paired by age and gender.

Results
Fourteen CZS cases presented microcephaly, maxillary prognathism, altered facial thirds, asymmetric pupillary line, bruxism (p = 0.006), deep and anterior open bite and distal step decidual molar relationship (p = 0.031). CZS children cannot feed by themselves and most cannot walk and have not develop coordinated and intelligible language according to their chronological age. In contrast, controls presented normal skull features, have autonomous locomotion skills, speak intelligible language, feed by themselves, presented a harmonic intermaxillary relationship and have symmetrical facial thirds.

Conclusion
Microcephaly, dysphagia, bruxism, mandibular retrognathia, altered facial proportions and malocclusion are the main craniofacial and oral features at CZS.

Clinical relevance
The complications of CZS including those related with the face and the oral cavity are still being identified. This study revealed some cranial, facial and oral features in children affected by CSZ. Interdisciplinary rehabilitation protocols must address these syndromic features that could improve children and parents living conditions.
Convergent and divergent intra- and internetwork connectivity in Parkinson’s disease with wearing-off
Authors: Zhai Heng , Fan Wenliang , Xiao Yan , Zhu Zhipeng , Ding Ying , He Chentao , Zhang Wei , Xu Yan , Zhang Yuhu 
Published: August 2023

Abstract
Objective
Our study aimed to explore the functional connectivity alterations between cortical nodes of resting-state networks in Parkinson’s disease (PD) patients with wearing-off (WO) at different levels.

Methods
Resting-state functional magnetic resonance imaging was performed on 36 PD patients without wearing-off (PD-nWO), 30 PD patients with wearing-off (PD-WO), and 35 healthy controls (HCs) to extract functional networks. Integrity, network, and edge levels were calculated for comparison between groups. UPDRS-III, MMSE, MOCA, HAMA, and HAMD scores were collected for further regression analysis.

Results
We observed significantly reduced connectivity strength in the dorsal attention network and limbic network in the PD-WO group compared with the HC group. The PD-WO group showed a decreased degree of functional connectivity at 12 nodes, including the bilateral orbital part of the superior frontal gyrus, right olfactory cortex, left medial orbital part of the superior frontal gyrus, bilateral gyrus rectus, right parahippocampal gyrus, right thalamus, left Heschl’s gyrus, right superior temporal gyrus part of the temporal pole, left middle temporal gyrus part of the temporal pole, and right inferior temporal gyrus. Furthermore, the PD-WO group showed a significantly lower degree of functional connectivity in the left orbital part of the superior frontal gyrus and right gyrus rectus than the PD-nWO group. Internetwork analysis indicated reduced functional connectivity in five pairs of resting-state networks.

Conclusion
Our results demonstrated altered intra- and internetwork connections in PD patients with WO. These findings will facilitate a better understanding of the distinction between the network changes in PD pathophysiology.
Medical versus neurosurgical treatment in ICH patients: a single center experience
Authors: Pierini P. , Novelli Agnese , Bossi F. , Corinaldesi R. , Paciaroni M. , Mosconi M. G. , Alberti A. , Venti M. , de Magistris I. Leone , Caso V. 
Published: August 2023

Abstract
Background and aims
The effect of surgical treatment for spontaneous intracerebral hemorrhage (ICH) remains uncertain. We conducted an observational retrospective cohort study on supra-centimeter spontaneous ICH treated with either neurosurgical or conservative management. The baseline demographics and risk factors were correlated with in-hospital mortality and 3 and 6-month survival rates stratified by management.

Methods
We included all patients with evidence of spontaneous ICH > 1 cm detected by CT and admitted between august 2020 and march 2021 to the “SMM” Hospital in Perugia.

Results
Onehundredandtwentytwo patients were included in the study, and 45% (n.55) were surgically treated. The mean age was 71.9 ± 15.3, and 61% (n.75) were males. Intra-hospital mortality ended up being 31% (n.38), 3 months-survival was 63% (n.77) and 6 months-survival was 60% (n.73).
From the multivariate analysis of the surgical patients versus medical patient, we observed that the surgical patients were younger (67.5 ± 14.9 vs 75.5 ± 14.7 y; OR 0.87; Cl 95% 0.85–0.94; p 0.001), with greater ICH volume at the onset (61 ± 39.4 cc vs 51 ± 64 cc; OR 1.03; Cl 95% 1.005–1.07; p 0.05), more midline shift (7.61 ± 5.54 mm vs 4.09 ± 5.88 mm; OR 1.37; Cl 95% 1.045–1.79; p 0.023), and a higher ICH score (3 vs 2 mean ICH score; OR 21.12; Cl 95% 2.6–170.6; p 0.004). Intra-hospital mortality in the surgical group and in the conservative treatment group was respectively 33% vs 30%, 3 month-survival was 64% vs 63% and 6 month- survival were 60% in both groups.

Conclusions
Our patient cohort shows no overall benefit from surgery over conservative treatment, but surgical patients were younger and had larger ICH volume.
Psychological and Behavioural Within-participant Predictors of Adherence to Oral HIV Pre-Exposure Prophylaxis (PrEP)
Authors: Taylor Alison , Hayes Rosalie , Nwokolo Nneka , Whitlock Gary , Dosekun Olamide , McCormack Sheena , Gafos Mitzy , Evangeli Michael 
Published: August 2023

AbstractOral PrEP’s effectiveness relies on adequate adherence during periods of substantial HIV risk. Since most PrEP users will miss doses, understanding predictors within participants can help to explain adherence. We used a cross-sectional, within-participant design with 67 gay, bisexual, and other men who have sex with men taking PrEP daily. Using a questionnaire, informed by the Information Motivation Behavioral Skills Model, participants were asked about an adherent and a non-adherent episode. PrEP non-adherence was associated with non-normality of the day (p < .001), being out of the home (p < .001), weekend days (p = .01), having company (p = .02), using substances (p = 0.02), not using reminders (p = .03), lower PrEP information (p = .04), lower behavioural skills (p < .001) and less positive affect (p = .002). PrEP adherence assessment could focus on situational variations, supporting the construction of alternative strategies to facilitate adherence in these situations.
Chlorella in aquaculture: challenges, opportunities, and disease prevention for sustainable development
Authors: Aly Salah M. , ElBanna Noha I. , Fathi M 
Published: August 2023

AbstractAquaculture is the farming of aquatic organisms like fish, crustaceans, mollusks, and aquatic plants, which has become a crucial source of protein and income. However, bacterial infections pose a significant challenge to the aquaculture industry and traditional treatments, such as antibiotics and chemicals, have limitations and environmental concerns. Disease prevention and control measures, such as the use of probiotics, vaccines, and biosecurity measures, are essential for the sustainable development of the aquaculture industry. Further research is also needed to develop more effective and sustainable strategies for the prevention and control of bacterial fish pathogens in aquaculture, where alternative treatments such as herbal extracts, essential oils, and probiotics require further investigation for efficacy and safety. Microalgae, particularly Chlorella, have potential applications in various industries such as biofuels, pharmaceuticals, and wastewater treatment. However, their large-scale production and commercialization face challenges. Safety of Chlorella to fish is a crucial issue that requires careful evaluation, with hematology being an essential tool to assess its effects on fish health and physiology. Studies show that Chlorella is safe for fish and does not have adverse effects on growth, survival, or immune system function. Chlorella is a safe and sustainable option for aquaculture, free from harmful chemicals and antibiotics. The Green Water System utilizes Chlorella as a natural filter and nutrient recycler, improving water quality and providing a well-balanced diet for aquatic animals. This eco-friendly approach also enhances fish immune systems, growth rates, and survival rates. The scientometric review shows significant research activity, with Chang JS being a prominent author and People’s R China and the Chinese Academy of Sciences leading in contributions. The use of Chlorella shows promise as an alternative treatment for bacterial fish pathogens in aquaculture due to its antibacterial properties, safety, and sustainability. However, challenges such as cost-effectiveness and standardization need to be addressed for successful implementation in the aquaculture industry.
Neoadjuvant carboplatin in triple-negative breast cancer: results from NACATRINE, a randomized phase II clinical trial
Authors: de Pádua Souza Cristiano , Carneiro Ana Suellen Barroso , de Oliveira Lessa Ana Cecília , Lacerda Domício Carvalho , Paiva Carlos Eduardo , Zorzetto Marina Moreira Costa , de Freitas Ana Julia Aguiar , Santana Iara Viana Vidigal , de Oliveira Marco Antonio , Palmero Edenir Inêz , Marques Márcia Maria Chiquitelli , Reinert Tomás 
Published: August 2023

Abstract
Background
Neoadjuvant chemotherapy (NACT) is the mainstay of treatment of stages II and III triple-negative breast cancer (TNBC). This study aims to evaluate if the addition of carboplatin to NACT is associated with an increase in the pathological complete response (pCR) rates in TNBC.

Methods
We conducted an open-label phase II randomized clinical trial in a single center in Brazil. Patients with stage II and III TNBC were randomized to receive standard NACT with or without carboplatin. All the patients received doxorubicin (60 mg/m2) plus cyclophosphamide (600 mg/m2) both intravenously (i.v.) q21 days for four cycles. Patients were then randomized for additional treatment with weekly (wk) paclitaxel (80 mg/m2 i.v., for 12 cycles) plus wk carboplatin AUC 1.5 (experimental arm) or without wk carboplatin (control arm). Randomization was stratified according to gBRCA status, age, and AJCC 8th edition clinical stage (II vs. III). The primary endpoint was the pathologic complete response (pCR) rate. Secondary endpoints included recurrence-free survival and overall survival.

Results
Between 2017 and 2021, 146 patients were randomized, 73 on each arm. The median age was 45 years. Most patients (66.4%) had locally advanced stage III disease, 67.1% had T3/T4 tumors, and 56.2% had clinically positive axillary lymph nodes. Germline BRCA status was available for all patients, and 19.9% had pathogenic BRCA1/2 variants. The pCR rate (ypT0ypN0) was numerically increased by 13.7%, being 43.8% (31 of 73 patients) in the experimental and 30.1% (22 of 73 patients) in the control arm, not meeting the prespecified goal of increasing the pCR in 15% (p-value = 0.08). Survival outcomes are immature.

Conclusion
The addition of carboplatin to standard NACT in stages II and III TNBC was associated with a non-statistically significant numerical increase in the pCR rate. Follow-up for survival outcomes and translational research initiatives are ongoing.
The Integration of Gender Equality (SDG 5) into University Teaching: the View from the Frontline
Authors: Merma-Molina Gladys , Urrea-Solano Mayra , Hernández-Amorós María J. 
Published: August 2023

AbstractMost universities are working committedly towards achieving the Sustainable Development Goals (SDG). The University of Alicante (UA) (Spain) has designed a series of strategies to help crystallize its aims within these goals, including those related to gender equality (SDG 5). Given the context, the aims of this study are (1) to find out whether teachers integrate SDG 5 into their teaching and, if so, what strategies they use, (2) to analyse how they perceive the effects of this and what factors help or hinder the process, and (3) to check for possible differences in these perceptions according to sex and faculty. Some 310 teachers from all the UA faculties participated. A descriptive and comparative analysis was performed, as was a content analysis. Half of the participants were found to be implementing these strategies, with women in general and teachers from the Faculty of Humanities in particular appearing to be most aware of the subject. However, only a minority applied them on a mainstream basis. The most used strategy was inclusive language. Other strategies, such as reflecting on equality, promoting equal participation, visibilizing women in different areas of knowledge, equal treatment of students and gender research, were also present in their narratives but to only a very small degree. Improved professional development for teachers and greater student awareness of gender issues were identified as positive effects of incorporating these strategies. Participants also felt that low awareness and a lack of time and training were obstacles to the process. Universities should therefore establish specific institutional policies aimed at integrating SDG 5 as a quality indicator. Training programmes should be redesigned to take into account a more practical approach, the type of learning (classroom, online or mixed), and subsequent follow-up in the classroom to guarantee effective integration.
Road to Equity in Maternal and Child Health: Honoring the Past and Blazing New Paths
Authors: Rowley Diane L. , Hogan Vijaya K. , Abresch Chad 
Published: August 2023

Abstract
Purpose
This paper is a historical account of an initiative, as recalled by the authors who were directly involved, that brought to the forefront the long-standing and unjust reproductive health inequities in the United States. It is composed of three distinct but interrelated parts that together map the past, present, and future of addressing racial inequities in Maternal and Child Health.

Description
This paper is composed of three distinct but interrelated parts that together map the past, present, and future of addressing racial inequities in Maternal and Child Health. Part I recounts the history and achievements of a Centers for Disease for Control and Prevention initiative in the 1980–90’s, led by the Prematurity Research Group in the Division of Reproductive Health, Pregnancy and Infant Health Branch. This initiative stimulated a paradigm shift in how we understand and address black infant mortality and the inequities in this outcome. Part II illustrates examples of some exemplary programmatic and policy legacies that stemmed either directly or indirectly from the Centers for Disease for Control and Prevention paradigm shift. Part III provides a discussion of how effectively the current practice in Maternal and Child Health applies this paradigm to address inequities and proposes a path for accelerating Title V agencies’ progress toward birth equity.

Assessment
This CDC initiative was transformative in that it raised the visibility of African American researchers, moved the field from a focus on traditional epidemiologic risks such as personal health promotion and medical interventions, to include racism as a risk factor for inequitable birth outcomes. The paradigm examined the specific roles of historical and structural racism, and the racialized, contextualized, and temporal exposures that are unique to Black women’s experiences in the United States.

Conclusion
The initiative radically changed the narratives about the underlying factors contributing to inequities in birth outcomes of Black women, altered the way we currently approach addressing inequities, and holds the keys for transforming practice to a more holistic and systematic approach to building sustained organizational structures in maternal and child health that accelerate the achievement of birth equity.
Patch area and uniform sampling on the surface of any ellipsoid
Authors: Marples Callum Robert , Williams Philip Michael 
Published: August 2023

AbstractAlgorithms for generating uniform random points on a triaxial ellipsoid are non-trivial to verify because of the non-analytical form of the surface area. In this paper, a formula for the surface area of an ellipsoidal patch is derived in the form of a one-dimensional numerical integration problem, where the integrand is expressed using elliptic integrals. In addition, analytical formulae were obtained for the special case of a spheroid. The triaxial ellipsoid formula was used to calculate patch areas to investigate a set of surface sampling algorithms. Particular attention was paid to the efficiency of these methods. The results of this investigation show that the most efficient algorithm depends on the required coordinate system. For Cartesian coordinates, the gradient rejection sampling algorithm of Chen and Glotzer is best suited to this task, when paired with Marsaglia’s method for generating points on a unit sphere. For outputs in polar coordinates, it was found that a surface area rejection sampler is preferable.
Mr. Active and Little Miss Passive? The Transmission and Existence of Gender Stereotypes in Children’s Books
Authors: Pownall Madeleine , Heflick Nathan 
Published: August 2023

AbstractDo popular children’s books tend to reflect gender stereotypes, and do parents prefer their daughters to read books reflecting this pattern? We explored these research questions using the popular Roger Hargreaves’ Mr. Men and Little Miss collection of children’s storybooks, which is a series of individual stories all titled with and based on a binarized gendered character (e.g., Mr. Greedy, Little Miss Sunshine). Using a deductive content analysis approach, Study 1 revealed that the characters in the series’ 81 books tend to behave in gender stereotypical ways, with male characters more adventurous and active and female characters more domestic and passive. Books that had female leads were also more likely to have male secondary characters. In Study 2, participants rated the masculinity/femininity and positivity/negativity of the traits of each of the book series’ titular main characters without knowing the (gendered) book title. The traits used in Little Miss stories were associated with femininity, and the Mr Men story traits with masculinity. In Study 3, when faced with the prospect of selecting a Little Miss book to read to their daughter, parents preferred counter-stereotypical book choices (e.g., Little Miss Brainy). Perceived consistency with what parents wanted to teach their daughters about women predicted this book choice. Overall, although these books tended to reflect traditional gender stereotypes (Studies 1, 2), and people held these beliefs (Study 3), we found that parents wanted a counter-stereotypical book for their daughter. Implications for the transmission of gender stereotypes via children’s literature and parental choices are discussed.
Integrative views of representations and processes in morphology: an introduction
Authors: Marzi Claudia , Pirrelli Vito 
Published: August 2023

AbstractOne of the most enduring conceptualisations of the language architecture rests on a modular subdivision of work between lexical representations of stored items on the one hand, and dynamic processes, modelled as procedural rules working on such items, on the other hand. In morphology, network-based approaches have suggested an alternative “integrative” view of word representations and processes, where lexical representations consist of partially overlapping activation patterns spreading over several processing units. From this integrative perspective, the resulting network isbotha lexiconanda word processor. We argue that the network-based view provides a stimulating research framework for several complementary levels of language inquiry (including theoretical, computational and neuro-psychological approaches) to be fruitfully integrated into a novel, comprehensive understanding of morphology. We discuss some implications of this view and delineate prospects of progress in this area.
Reducing Bias and Quantifying Uncertainty in Fluorescence Produced by PCR
Authors: DeJaco Robert F. , Roberts Matthew J. , Romsos Erica L. , Vallone Peter M. , Kearsley Anthony J. 
Published: August 2023

AbstractWe present a new approach for relating nucleic-acid content to fluorescence in a real-time Polymerase Chain Reaction (PCR) assay. By coupling a two-type branching process for PCR with a fluorescence analog of Beer’s Law, the approach reduces bias and quantifies uncertainty in fluorescence. As the two-type branching process distinguishes between complementary strands of DNA, it allows for a stoichiometric description of reactions between fluorescent probes and DNA and can capture the initial conditions encountered in assays targeting RNA. Analysis of the expected copy-number identifies additional dynamics that occur at short times (or, equivalently, low cycle numbers), while investigation of the variance reveals the contributions from liquid volume transfer, imperfect amplification, and strand-specific amplification (i.e., if one strand is synthesized more efficiently than its complement). Linking the branching process to fluorescence by the Beer’s Law analog allows for an a priori description of background fluorescence. It also enables uncertainty quantification (UQ) in fluorescence which, in turn, leads to analytical relationships between amplification efficiency (probability) and limit of detection. This work sets the stage for UQ-PCR, where both the input copy-number and its uncertainty are quantified from fluorescence kinetics.