bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiologia das infecções endodônticas: uma breve revisão
Authors: Do Nascimento Samara Lima , Magalhães Mylena Cristina Cavalcanti , Lessa Samara Verçosa 
Published: July 2023

Objetivo: Destacar o papel dos microrganismos no insucesso no tratamento endodôntico. Revisão da literatura e discursão: Bactérias resistentes mesmo após tratamento é tido como um dos principais fatores colaboradores dos insucessos, devido a deficiência do tratamento ou não, apresentando em momentos distintos onde se faz necessário o conhecimento da evolução desta microbiota, nas diversas etapas da patogenia para resolução da infecção, estudos mostram a diversidade de bactérias encontradas intra e extraradicular, sua adaptação aos meios agressivos e microambientes. Conclusão: Não apenas a bactéria tem resistência, mas uma colônia que já está presente pode permanecer e se propagar porque são bactérias oportunistas, que podem variar de acordo com o estágio em que se encontram; emergente, persistente e recorrente. Existem várias formas de acesso, desde uma etapa do procedimento descuidada até uma restauração infiltrada, a complexidade das causas mostra uma necessidade de abordagem e qualificação profissional na execução.
Tratamento ortodôntico associado ao fechamento de diastema: revisão de literatura
Authors: Esteves Ana Clara Pinheiro , Carvalho Daiane Santos , Lima Daniel Ferraz 
Published: July 2023

Introdução: Definem-se diastemas como espaço ou ausência dos pontos de contatos entre dois ou mais elementos dentais contíguos na arcada dentária superior ou inferior, podendo afetar crianças e adultos. Sua etiologia possui um caráter multifatorial, podendo interferir na função e na fonação do paciente. Atualmente, encontra-se diferentes possibilidades para realizar a reparação dos espaços interdentais. Objetivo: Dissertar sobre o diastema, abordando a etiologia, o diagnóstico e as possíveis formas de tratamento, enfatizando o tratamento ortodôntico. Metodologia: O presente estudo foi elaborado a partir de uma revisão da literatura nas bases de dados Pubmed, Scielo, Lilacs e BVS, por artigos científicos descritos na língua portuguesa e inglesa no período entre 2018 e 2023. Discussão: As abordagens em planejamentos de casos clínicos estéticos ou funcionais para os diastemas, envolvem uso do aparelho ortodôntico, em sua maioria, principalmente em casos que são necessários ajuste de oclusão. Nota-se que ao longo dos anos, a ortodontia continua como tratamento de eleição, o que evidencia sua eficácia e longevidade. Independente da conduta escolhida pelo profissional, faz-se necessário uso de modelos de estudo, programas seguros que realizem medidas com precisão para melhor previsão do resultado final. Conclusão: Cabe aos profissionais selecionar as melhores opções de tratamento para os pacientes por meio de planejamento multidisciplinar, analisando a especificidade do indivíduo, a etiologia das lacunas e se estão relacionadas a anormalidades, de forma a promover resultados satisfatórios e duradouros.
Diagnóstico precoce do Câncer de Colo do Útero utilizando biomarcadores tumorais P16 e Ki67: uma revisão sistemática
Authors: Feitoza Ellen Nunes , Oliveira Daniel de Oliveira , Carvalho Bruna Mendes , Andrade Micaele Lima 
Published: July 2023

INTRODUÇÃO: O câncer de colo de útero, é uma neoplasia maligna localizada no colo do útero (porção entre o final da vagina e o útero) é uma doença que evolui ao logo dos anos. Para diagnosticar esta doença são necessárias diversas ferramentas, dentre elas está o uso de biomarcadores, como o biomarcador P16 e Ki67. OBJETIVO: Descrever sobre os biomarcadores tumorais P16 e ki67 e descrever sua utilidade para a identificação, diagnóstico e prognóstico precoce do câncer de colo uterino. MÉTODOS: Trata-se de um estudo de revisão sistemática, utilizando o método PRISMA de revisões sistemáticas e meta-análises. Foram utilizadas bibliotecas virtuais como Scielo, PubMed e BVS para a busca dos artigos, com palavras chaves em português, inglês e espanhol. Foram incluídos artigos com data de publicação dentro dos últimos 10 anos, dentro do tema central deste estudo. RESULTADOS: Para embasar este trabalho, foi realizada a seleção de 15 artigos que fundamentaram o desenvolvimento do presente estudo. Dentre os biomarcadores abordados, destacam-se o P16 como uma proteína supressora de tumor, desempenhando papel fundamental na regulação do ciclo celular. Sua superexpressão dentro das células cervicais, indicam neoplasias intraepiteliais. O biomarcador Ki67 é outra proteína e está relacionada com a proliferação celular que indica a progressão de neoplasias intraepiteliais cervicais. No tecidonormal, é encontrado exclusivamente em células parabasais, a sua superexpresão em outras camadas do tecido cervical indica desregulação do ciclo celular provocada pelo HPV. Os estudos científicos mostram que os biomarcadores P16 e Ki67 são melhores quando utilizados em conjunto, pois a coexpressão dessas duas proteínas resultam na desregulação da célula e são geralmente detectáveis em lesões de grau mais elevados, quanto maior é o grau de lesão, maior é a expressão dessas duas proteínas. CONCLUSÕES: Com base dos estudos encontrados, os biomarcadores tumorais p16 e Ki-67 demonstraram ser ferramentas valiosas no diagnóstico e prognóstico do câncer do colo do útero. A presença de p16 é indicativa de uma lesão precursora de alto grau, enquanto a expressão de Ki-67 está relacionada à proliferação celular e à atividade tumoral. O uso desses biomarcadores pode fornecer informações mais precisas sobre o estágio ou grau da lesão cervical da doença e auxiliar na tomada de decisões terapêuticas. Portanto, a análise desses marcadores é essencial para a abordagem clínica eficaz do câncer cervical.
Analisis Promosi Dan Kualitas Pelayanan Terhadap Kepuasan Konsumen Pada Online Travel Agent (Traveloka, Tiket.Com, Agoda, Dan Pegi-Pegi)
Authors: Indriany Yunita , Sintesa Nika , Darmawan Darmawan 
Published: July 2023

<p align="justify">This study aims to determine and analyze the effect of Promotion and Service Quality on Consumer Satisfaction, either partially or simultaneously on the Online Travel Agent (Case Study of Traveloka, Tiket.com, Agoda, Pegi-pegi Customers). The type of research used is a quantitative approach. The sampling technique used was purposive sampling method, namely the data was selected based on certain criteria.. The data analysis method used was multiple linear regression analysis (SPSS). The results of this study indicate that: (1) Promotion (X1) partially has a positive and significant effect on consumer satisfaction as evidenced by the results of a significance t of 0.116; (2) Service Quality (X2) partially does not have a Positive and Significant effect on Consumer Satisfaction, this is evidenced by the results of a significance t of 0.000; Simultaneous promotion, and service quality have a significant effect on consumer satisfaction as evidenced by the results of a significance F of 0.000 which is smaller than 0.05.</p><p><strong>Keywords: </strong>Consumer Satisfaction, Promotion, Service Quality</p><div> </div>
MENAKAR ADOPSI CLOUD-BASED ACCOUNTING PADA USAHA MIKRO, KECIL, DAN MENENGAH DENGAN COMPUTER SELF-EFFICACY, COMPUTER ANXIETY DAN PERCEIVED ENJOYMENT SEBAGAI FAKTOR DETERMINAN
Authors: Permana Gusi Putu Lestara , Dwiyanti I Gusti Kadek Anggiriska 
Published: July 2023

Small and medium enterprises (SMEs) play a role in contributing to transformation in the better quadrant. SMEs have a positive effect on society and the economy because of their strategic value. SMEs use the simple financial record method, which can affect the decision-making process. Lack of ability in record keeping and financial management become a big issue. Implementing cloud accounting software is a way to reduce problems for SMEs due to the need to record their financial transactions. But not all SMEs use that software. This research conducted in Denpasar and involved 90 respondents. All the data analyzed with SPSS 24.0. The results found that each computer self-efficacy and perceived enjoyment had a positive and significant effect on behavioral intention, meanwhile computer anxiety had a negative and significant effect on behavioral intention to adopt cloud-based accounting in MSMEs
Las TIC como estrategia didáctica y apoyo en el aprendizaje de suma de vectores, en el nivel Medio Superior de la UAC
Authors: González Mayté Cadena , Bojórquez María Alejandra Sarmiento , Rosado Juan Fernando Casanova 
Published: July 2023

Observamos que el mundo ha tenido un avance acelerado en cuanto al uso de las TIC, por lo que el docente tiene la necesidad de actualizarse, adquirir experiencia y habilidades que fortalezcan el proceso enseñanza-aprendizaje e introducirlas en el aula como estrategias didácticas. Es una necesidad la incorporación de las TIC, pues son muchas las ventajas que ofrece, desde favorecer la motivación para el aprendizaje, hasta poder trabajar colaborativamente desde cualquier lugar.
A través de una investigación proyectiva este trabajo tiene como propósito el potencializar la estrategia didáctica: suma de vectores, mediante el uso de TIC.
Esta estrategia implementa el uso de simuladores y videos, para motivar a los estudiantes y fomentar el trabajo colaborativo; considerando que la física es una ciencia experimental, este tipo de recursos nos ayudan para retroalimentar el tema y poder experimentar.
En conclusión, la estrategia se apega a las nuevas tendencias del aprendizaje de una era digital, donde el uso de TIC motiva a los alumnos en el área de ciencias y favorecen el aprendizaje. Con la aplicación de esta estrategia obtenemos recursos didácticos para poder usar las TIC en el aula y fuera de ella, siempre observando y guiando a los alumnos en el desarrollo de competencias y en el uso adecuado de estas tecnologías.
Motion Graphic Media Pembelajaran Bahasa Isyarat Alfabet bagi Anak Tunarungu SDLB
Authors: Sayuti M , Pandawara Jov 
Published: July 2023

Pendidikan yang efektif dan inklusif bagi anak-anak tunarungu di Sekolah Dasar Luar Biasa (SDLB) membutuhkan pendekatan yang kreatif dan inovatif. Dalam konteks ini, perancangan media pembelajaran yang menggunakan motion graphic dapat menjadi solusi yang efektif dalam mengajarkan bahasa isyarat alfabet kepada anak-anak tunarungu. Tujuan penelitian ini adalah untuk merancang dan mengembangkan motion graphic sebagai media pembelajaran yang menarik, mudah dipahami, dan sesuai dengan kebutuhan anak-anak tunarungu di SDLB. Media pembelajaran ini bertujuan untuk membantu anak-anak tunarungu dalam menguasai dan memahami bahasa isyarat alfabet, yang merupakan alat komunikasi yang penting bagi mereka. Media pembelajaran yang efektif dan menarik dapat memainkan peran yang sangat penting dalam pendidikan anak-anak tunarungu di Sekolah Dasar Luar Biasa (SDLB). Dalam konteks ini, motion graphic media pembelajaran dapat menjadi alat yang efektif untuk mengajarkan bahasa isyarat alfabet kepada anak-anak tunarungu. Metode yang digunakan dalam penelitian ini adalah pendekatan perancangan instructional dengan beberapa tahapan, yaitu analisis kebutuhan, perancangan konten, pengembangan motion graphic, uji coba, dan evaluasi. Partisipasi anak-anak tunarungu di SDLB akan melibatkan mereka sebagai subyek penelitian dalam menguji keefektifan media pembelajaran yang dirancang. Analisis data menggunakan konsep teori I.D.U (Identification Benefit, Delivery Benefit, Unique Selling Proposition). Diharapkan pada pengembangan motion graphic media pembelajaran ini dapat memberikan kontribusi positif dalam pendidikan anak-anak tunarungu di SDLB.
LAS MUJERES EN LOS INICIOS DE LA UNIVERSIDAD MICHOACANA
Authors: Ramírez Barreto Ana Cristina 
Published: July 2023

Hay estudios sobre la injusticia y discriminación por sexo/género en las instituciones universitarias, generalmente identificada con metáforas como “techo de cristal” o “piso pegajoso” para quienes se identifican como no-varones, específicamente, mujeres. Aquí presento resultados de una exploración histórica referida a la Universidad Michoacana de San Nicolás de Hidalgo que muestra, documentalmente, decisiones que frenaron la presencia de mujeres en el nivel de la educación superior. Muestro que ello no se debió necesaria y exclusivamente a la acción maliciosa de algunos varones sino al apremio de actuar en las circunstancias en que se encontraban. Este trabajo es parte de un proyecto en ciencia aplicada. Se propone alentar la lectura pública a varias voces del Acta 14 del H. Consejo Universitario de la UMSNH, una reunión extraordinaria convocada por el rector Ignacio Chávez el 7 de marzo de 1921, para decidir cómo aplicar el debido castigo (expulsión) a una estudiante del quinto año de la Normal. La estudiante estaba a pocos meses de egresar de la carrera. La falta que cometió: estar visiblemente embarazada. Entender el contexto de este documento permite ver la complejidad de las acciones que convergen en esos años cruciales, para la UMSNH, para Michoacán y para México. La lectura pública propuesta será una oportunidad para reflexionar sobre los conceptos de daño, responsabilidad, castigo y poder en la universidad, enmarcados por la diferencia sexogenérica.
Pengembangan Buku Suplemen Berbasis Cerita Bergambar pada Mata Pelajaran IPAS di Kelas IV Sekolah Dasar
Authors: Norholis Norholis , Kresnadi Hery , Ghasya Dyoty Auliya Vilda 
Published: July 2023

This research and development aims to produce a supplementary book product based on illustrated stories in the subject of IPAS on the material of Indonesia's cultural wealth in class IV Elementary School which is feasible to use to assist the learning process in the independent curriculum. The method used is the Research and development (R&D) method by adapting the ADDIE model. 3 expert validators, 3 classroom teachers in the classroom, and 94 students were sampled in this study. strategies for collecting data through questionnaires and interviews. The results of research and development obtained a validity assessment according to the material expert validator in the content/material aspect obtained a percentage value of 82.23% with the criteria "Very Valid", according to the language expert validator in the language presentation aspect obtained a percentage value of 87.15% with the criteria "Very Valid", according to the design expert in the design aspect obtained a percentage value of 86.67% with the criteria "Very Valid", and according to the design expert validator in the graphical aspect obtained a percentage value of 82.50% with the criteria "Very Valid". These results are supported by the results of product trial activities and received a "Very Good" response from the teacher with a percentage value of 93.70% while responses from small group students obtained a percentage value of 85.52% which is the criterion of "Very Good", and large group responses obtained a percentage value of 88.81% which is the criterion of "Very Good". Therefore, it can be said that this picture story-based supplement book is suitable for use in the learning process.
De la propiedad a la otredad en la comunidad escolar: El cuidado común
Authors: Gutiérrez Rodríguez Rosa Martha 
Published: July 2023

La educación para el el cuidado del otro es cada vez más un asunto prioritario que abarca los ámbitos en los que se desarrolla la vida y que se reconoce institucionalmente como Educación ambiental. Tratándose de un tema emergente que nos encara con la degradación del planeta, pareciera que se limita sólo al desarrollo de acciones encaminadas a la preservación del agua y la naturaleza; no obstante, para realizar acciones de carácter socio-ambiental se hace necesario recuperar el sentido de la otredad desde la propiedad de los sujetos, la atención comunitaria y el sentido de pertenencia desde la propia visión de los sujetos que preservan la vida y el bienestar de los otros y de lo propio.
Desde esta posición se recupera el pensamiento de Leonardo Boff por el valor ético-ontológico de lo que se es y de lo que puede entenderse como virtud del ser en su relación con la vida en sus distintas formas y manifestaciones.
Enseñamos lo que somos: Hacia una educación conciente
Authors: Lara Daganzo Trinidad 
Published: July 2023

Cuando educar es sinónimo de instruir, o acumular conocimientos que nos ayudan a dar continuidad a los imperativos sociales (acumular mucho y rápido), estamos hablando del enfoque no esencial superficial, competencial o pragmático, de la educación. Es una parte, pero no el todo. La educación holística requiere del ámbito esencial, que a diferencia de su complementario no es demandado por la sociedad. En cambio, es el que nos sana.
El origen es lo esencial, profundo, invisible y atemporal. Preguntémonos si la mirada no habría de estar en vaciar, desaprender, ralentizar y minimizar.
Los educadores tenemos el deber y privilegio de promover el cuestionamiento de todos aquellos patrones sociales estériles que están necrosando el sentido de la vida.
La educación consciente demanda de un autoconocimiento ilimitado, que nos direccione al derrumbe del ego. Un darse cuenta de nosotros mismos. Para ello la auto-educación es el camino, pues los educadores enseñamos lo que nosotros mismos hacemos para auto-educarnos.
Mean Best Corrected Visual Acuity after Intravitreal Bevacizumab in Patients with Diabetic Macular Edema
Authors: Hanif Anum , Zahra Qundeel , Mansoor Atif , Arshad Mahmood Muhammad , Saeed Muhammad 
Published: July 2023

Purpose: To determine mean best corrected visual acuity after intravitreal bevacizumab in patients with diabetic macular edema.
Study Design: Quasi experimental study.
Place and Duration of Study: Jinnah Hospital, Lahore and Chaudary Muhammad Akram Hospital Lahore from March 2018 to May 2021.
Methods: A total of 200 patients of either gender with diabetic macular edema and age between 40 and 60 years were included in this study. Patients with dense cataract, corneal opacity, uncontrolled diabetes mellitus and those who were treated with pan retinal photocoagulation were excluded. Best corrected Visual Acuity (BCVA) was evaluated with Snellen chart and converted to log MAR. A standard protocol of 0.05 mL of Bevacizumab was prepared from injection Avastin, 100 mg/4 mL vial. Bevacizumab injection was given to all patients, using topical anesthesia, under aseptic measures in the operation theater. A total of 03 injections were given at 1-month interval. After three months, BCVA was recorded. Results were presented in number and percentages.
Results: Mean age of the participants was 50.42 ± 6.48 years. Male to female ratio was 1:1.6, with 78 (39.0%) men and 122 (61.0%) women. Mean duration of diabetes mellitus was 5.12 ± 2.23 years. Mean pre-treatment BCVA was 0.51 ± 0.05 and mean post-treatment BCVA at three months was 0.26 ± 0.22.
Conclusion: Mean BCVA is increased after intravitreal injection of Bevacizumab in patients with diabetic macular edema.
Awareness and Referral Attitudes of Diabetic Retinopathy among Surgeons at a Tertiary Care Hospital in Pakistan
Authors: Malik Muhammad Bilal , Chippa Shaukat Ali , Rashid Asma , Akram Sharmeen 
Published: July 2023

Purpose: To assess the awareness of diabetic retinopathy (DR) in surgeons and compare their referral practices from different specialities at a tertiary care center.
Study Design: Cross sectional survey.
Place and Duration of Study: Department of Surgery, Agha Khan University Hospital, Karachi.
Methods: A survey was created using Google Forms and the link to the survey was shared to 99 surgery faculty members on official university email addresses. We employed non-probability, convenience sampling technique and the total population of faculty under the Department of Surgery was sampled, including clinical fellows. Residents, research associates, and ophthalmology faculty were subsequently excluded. The survey contained questions in 4 categories; consent, relevant practices of DM, knowledge regarding DR and referral practices to an ophthalmologist. Scoring was based on a 5-point Likert scale with 5 being the most rigorous practice. Data was entered into SPSS v.23. Qualitative data was reported as frequencies with percentages, and quantitative data was reported as mean with standard deviation.
Results: Out of 40 participants, 87.5% had excellent practices of diabetes mellitus and 77.5% had excellent knowledge of diabetic retinopathy. Referral practices to an ophthalmologist were graded fair in 75% and poor in 15% whereas, referral practices were fair or poor across all surgical specialties.
Conclusion: Our study indicates a gap between knowledge and practices of surgeons regarding DM. Hence, there is a strong need to enhance awareness about timely referrals to an ophthalmologist to prevent complications of diabetes related blindness.
Orbital Vascular Malformations – Clinical Presentation and Management Strategies
Authors: Shoaib Khawaja Khalid , Mehmood Ahsan 
Published: July 2023

Purpose: To describe clinical features and management of Orbital Vascular Malformations (OVM) presenting to a tertiary care hospital of Lahore.
Study Design: Interventional case series.
Place and Duration of Study: Mughal eye hospital and Lahore General Hospital, Lahore, from January 2018 to December 2021.
Methods: A total of 26 patients with OVM were included in the study. All the patients underwent complete ocular examination. CT scan and digital subtraction angiography was performed for conformation and extent of the lesions. The patients were photographed after informed consent to publish the photos. Management of three cases (representing three modalities) has been described in detail.
Results: Out of 26 patients, there were 16 males and 10 females. Mean age at presentation was 15 years (range 2 – 35 years). There were 14 cases with lymphatico-venous malformation (LVM) and 12 cases with arterio-venous malformation (AVM). One patient underwent surgical excision, second patient was managed with intralesional Bleomycin injection and in the third case, and intra-arterial embolization was performed by interventional radiologist. All three modalities proved successful in terms of function and cosmesis.
Conclusion: Orbital vascular malformations are uncommon lesions. Resection, sclerosing agent injection and intra-arterial embolization are successful treatments.
Effect of Intravitreal Aflibercept on Wet Age-Related Macular Degeneration and Evaluation of Risk Factors on Patient’s Response
Authors: Alkazraji Rasha Abdulelah Mustafa , Ali Samara M , Hussein Zaid Rajab 
Published: July 2023

Purpose: To evaluate the effect of intravitreal Aflibercept injection on wet AMD both functionally and anatomically after loading doses. The secondary aim is to evaluate the effect of risk factors including (gender, age, smoking, hypertension, and diabetes meatus) on the patient’s response.
Study Design: Interventional case series.
Place and Duration of Study: Al-Haitham Eyes Teaching Hospital in Baghdad, Iraq, from November 2021 and September 2022.
Methods: Fifty eyes of 47 patients with treatment naïve wet AMD were selected through convenient sampling. Data were collected for age, gender, smoking, and chronic disease. Clinical examination, best corrected visual acuity (BCVA), optical coherence tomography angiography, and spectral domain optical coherence tomography SD-OCT were performed at baseline and then at 16 weeks, after three one-monthly injections of Aflibercept 2 mg/ 0.05 ml intravitreally.
Results: Mean age was 68.23 ± 8.5 years. Mean difference in BCVA was 0.37 ± 0.03 (P = 0.000) and mean difference in central macular thickness was 105.72 ± 45.05 (P value < .0000) at 16 weeks. CNV was associated with intra-retinal fluid in 52% of cases, subretinal fluid in 72%, pigment epithelial detachment in 20%, intraretinal hemorrhage in 6% and subretinal hemorrhage in 4%. Studying associations between the responses of Aflibercept with the general features of the patients as age, gender, chronic diseases and smoking status, revealed no statistically significant difference.
Conclusion: This study demonstrates that aflibercept is effective for the treatment of patients with wet AMD both functionally and anatomically after the loading doses. The presence of intraretinal fluid at presentation had a negative effect on the vision.