bluuebunny/crossref_metadata_2025_split huggingface dataset:
To Study the Efficacy and Safety of Diosmin with Tranexamic Acid and Mefenamic Acid Versus only Tranexamic Acid and Mefenamic Acid in Medical Management of Abnormal Uterine Bleeding: A Randomized Controlled Trial
Authors: Sharma J. B. , Kumari Rajesh , Kumari Supriya , Jain Shubhangi , Dharmendra Sona 
Published: September 2023

Background:
Abnormal uterine bleeding (AUB) is a common problem in reproductive age group and perimenopausal age group being responsible for many outpatient visits. Traditional management of AUB consists of giving mefenamic acid, tranexamic acid, or their combination with progestogens or hormonal intrauterine deviced levonorgestrel intrauterine system (LNG-IUS) for severe or nonresponsive cases. The objective of the current study was to study the efficacy and safety of adding diosmin along with tranexamic acid and mefenamic acid in reducing menstrual blood loss in AUB patients.

Materials and Methods:
It was a prospective double-blind randomized controlled trial in which 900 mg of diosmin was given once daily along with 500 mg tranexamic acid and 250 mg mefenamic acid during menstruation (Group I-92 patients), or only tranexamic acid and mefenamic acid during menstruation (Group II-92 patients).

Results:
Mean age, parity, body mass index, and socioeconomic status were similar in the two groups. It was 35.68 years versus 36.78 years, 2.2 versus 2.3, 23.68 kg/m2 versus 24.62 kg/m2 respectively. Mean days of bleeding before this treatment were 6.8 versus 6.6 (P = 0.33) and were 3.5 versus 5.2 (P = 0.02) after treatment. There was a significant reduction in both groups as compared to before treatment (P = 0.021 in Group I, 0.027 in Group II) but the reduction was greater in Group I (P = 0.02). The amount of blood loss was 385 ml versus 390 ml (P = 0.7) before treatment which was significantly reduced in both groups to 68 ml versus 112 ml (P = 0.02 in Group I, 0.03 in Group II) with more decrease in Group I than in Group II (P = 0.01). Mean hemoglobin at beginning of the study was 8.4 versus 8.5 g/dl in Group I and Group II (P = 0.02) and significantly increased in both groups posttreatment to 10.9 and 9.8 g/dl in Group I and Group II (P = 0.012 in Group I, 0.011 in Group II) with increase being more in Group I than Group II (P = 0.03). Pictorial blood assessment chart score was 398 versus 406 (P = 0.35) before treatment and decreased significantly to 86.5 and 110.5 (P = 0.001 in Group I, 0.001 in Group II) with more decrease being in Group I than II (P = 0.01). There was significant decrease in dysmenorrhea with both treatments with no difference in the two groups. Various adverse effects such as nausea, vomiting, abdominal pain, diarrhea, constipation, and headache were equal in the two groups.

Conclusion:
Both the group’s diosmin with tranexamic acid and mefenamic acid (Group I) and tranexamic acid and mefenamic acid (Group II) were efficacious in reducing menstrual blood loss, number of menstrual days and dysmenorrhea with effect being more by addition of diosmin. Adverse effects were equal in both the two groups.
Impact of Menopausal Duration on Salivary Flow Rate, Tooth Loss, and Oral Health-related Quality of Life in Indian Communities
Authors: Krupa N. C. , Thippeswamy H. M. , Chandrashekar Byalakere Rudraiah , Thetakala Ravi Kumar 
Published: September 2023

Background:
Diminishing hormonal levels after menopause evoke physiological changes in a woman’s body. Their effects on the oral cavity are noteworthy, considering symptoms of dry mouth, altered taste perceptions, and tooth loss that may be attributed to reduced salivary flow and alveolar density changes.

Aim:
The purpose of this study was to assess changes in salivary flow rate, tooth loss, and oral health-related quality of life (OHRQoL) as menopausal duration increased.

Materials and Methods:
A total of 327 women fulfilling the eligibility criteria were chosen from two villages in the Mysuru district, Karnataka. They were categorized into three groups based on menopausal durations. Salivary flow rates, number of teeth lost, and OHRQoL after menopause were assessed and compared at different menopausal durations. Sociodemographic characteristics and oral hygiene practices were recorded to identify potential confounders.

Results:
Multivariate analysis demonstrated a significant association between menopausal duration and salivary flow rates (adjusted odds ratio = 2.269). However, no such associations were observed with tooth loss and OHRQoL.

Conclusion:
Menopausal duration significantly affects salivary flow rate. Its influence on tooth loss and OHRQoL is, however, less evident. Although strong associations cannot be established, the inevitability of the menopausal state advocates consideration of other major yet modifiable factors to improve oral health.
Expression of Programmed Cell Death Ligand-1 and Mismatch Repair Status in Endometrial Carcinomas
Authors: Rajendran Madhubala , Rao Meenakshi , Elhence Poonam Abhay , Bharti Jyotsna Naresh , Singh Pratibha , Yadav Garima , Nalwa Aasma , Goyal Akhil Dhanesh 
Published: September 2023

Background and Aims:
Programmed death ligand-1 (PD-L1) is a co-regulatory molecule that suppresses local immunity, and mismatch repair (MMR) deficiency (dMMR) is reported to influence the response to anti-PD-L1-targeted therapy. This study was conducted to find the PD-L1 status, the occurrence of dMMR in endometrial carcinomas, and the association between them.

Materials and Methods:
The study included 35 resected specimens of endometrial carcinomas represented on formalin-fixed paraffin-embedded sections from January 2016 to July 2020. The clinicopathologic information including patient age, tumor histologic type, grade, stage, lymphovascular invasion, the extent of myometrial invasion, and the percentage of tumor-infiltrating lymphocytes (TILs) were obtained in all cases. The expression of PD-L1 and MMR antibodies including mutS homolog 2 (MSH-2), MSH-6, mutL homolog 1 (MLH-1) and MLH-3, and postmeiotic segregation 2 were assessed using immunohistochemistry. The statistical analysis was done using the Statistical Package for the Social Sciences (SPSS) version 26.

Results:
PD-L1 expression was noted in 48.6% of the cases in tumor cells and 65.7% of the cases in TILs and MMR was deficient in 28.6% of endometrial carcinomas. A statistically significant relation was noted between dMMR and TILs, PD-L1 expression in tumor cells and TILs, PD-L1 expression in tumor cells, and extent of myometrial invasion. Although there was no statistically significant association between MMR status and PD-L1 expression in tumor cells or TILs, 60% of patients with dMMR were PD-L1 positive.

Conclusion:
Sixty percent of dMMR cases showed PD-L1 expression in tumor cells. We conclude, ECs that are MMR deficient might get better response to anti-PD-L1 therapy. This study also revealed the prognostic use of TILs in PD-L1-expressed tumors.
Nursing Care through ICTs in Hypertensive Teachers with Cardiovascular Risk in a Primary Care Centers
Authors: Gallegos-Espinoza Djamila , Piñas-Rivera Livia , Asencios-Trujillo Lucía , LaRosa-Longobardi Carlos , Asencios-Trujillo Lida , Perez-Siguas Rosa 
Published: September 2023

Introduction: Cardiovascular diseases (CVD) are a group of disorders of the heart and blood vessels and are the leading cause of death worldwide. In turn, they seem to affect men and women differentially, being the most frequent cause of death in the latter worldwide, even in developing countries. Aim: to determine Nursing care using ICTs in hypertensive teachers with cardiovascular risk in a primary care center in North Lima. primary school in North Lima. Methods: a quantitative, descriptive-cross-sectional study, with a population of 265 participants who answered a questionnaire of sociodemographic aspects and the cardiovascular risk calculator. Results: we could observe that 4.2% have very high cardiovascular risk, 10.9% high cardiovascular risk, 37.4% moderate cardiovascular risk and 47.5% very low cardiovascular risk. Conclusions: the person with high blood pressure should be educated about the risks that the disease can generate, and how to minimize the risks that may affect their health well-being.
Web information system and management of the graduate follow-up standard in a Public Institute of Higher Technological Education, Peru
Authors: Macedo-Figueroa Julio , Antunez-Carrillo Dennis , Diaz-Vega Enrique , Marín-Rodriguez William , Vasquez-Trejo Cesar , Barrenechea-Alvarado Julio 
Published: September 2023

The objective of the research was to establish the relationship between the web information system and the follow-up standards for graduates in a Public Higher Technological Education Institution, Peru, during 2022. Materials and Methods: It corresponds to a non-experimental design of descriptive correlational design. Results: It was shown that 67.4% of the graduates of this institution obtained a medium level in the use of the Web Information System, 19.6% acquired a higher level and 13.0% showed a minimum level, 50.0% of the graduates had a medium level, with respect to the graduate follow-up standard variable, 26.1% acquired a minimum level and 23.9% showed a high level. Conclusions There is a significant and positive relationship, obtaining a Spearman's Rho coefficient of 0.873, between the web information system and the graduate monitoring standards of the Public Higher Technological Education Institution, Peru.
Hysteroscopic management of infected and partially discharged desidual cast in an adolescent: A case report and review of the literature in adolescents
Authors: Telli Elcin , Arda Mehmet Surhan 
Published: September 2023

Objective: Decidual cast in other words membranous dysmenorrhea is a rare entity. Hereby, we report the first infected case caused by drospirenon containing contraceptive use and managed successfully by hysteroscopy.
Case presentation: A13 year-old girl started on drospirenon containing contraceptive theraphy since her menarche resulted in menorrhagia and anemia that requires transfusion. On follow up, she developed a partially discharged infected mass revealed to be a decidual cast on pathological review.
Discussion: Membranous dysmenorrhea occurs more frequently in the adolescent and young adult population. All cases in this review were on hormonal theraphy except one occured spontaneously. Cast formation of the immature uterus after menarche is an exaggerated response to dose-independent increased progestin levels.
Conclusion: We conclude that diagnosis of decidual cast/membranous dysmenorrhea should be kept in mind for colicky pain with bleeding of adolescents under hormonal contraceptive therapy and partially discharged cases may be managed successfully by hysteroscopy.
Impact of the type of ductus venosus agenesis and the presence of associated anomalies on prognosis
Authors: Acar Züat , Başkıran Yusuf 
Published: September 2023

Objective: The Ductus Venosus (DV) connects the umbilical vein to the inferior vena cava. With a portocaval pressure gradient, the well-oxygenated blood in the ductus venosus accelerates towards the left sidewall of the inferior vena cava, directing the blood preferentially towards cephalic and coronary circulation through the foramen ovale (1). DV serves as a shunt, expanding to protect the heart and brain in hypoxic conditions. Ductus Venosus Agenesis (DVA) is a rare congenital abnormality with a prevalence of 0.03-0.07%. The type of DVA, along with any additional anatomical or chromosomal anomalies in fetuses with DVA, significantly affects the postnatal prognosis. Some fetuses with DVA develop normally, while others may experience growth retardation, heart defects, or other complications. In this study, we aimed to evaluate the frequency of associated anomalies in DVA cases, examine the impact of each type of DVA (intrahepatic and extrahepatic venous drainage) on prognosis, and contribute to the literature on this rare disease.
Materials and Methods: We conducted a retrospective study of all cases diagnosed prenatally with DVA at a tertiary center between 2016-2019. Our study reviewed obstetric data, associated anomalies, other systemic anomalies, type of DVA, chromosomal or genetic anomalies, and perinatal and postnatal outcomes. Postnatal infants were followed up to the 6th month.
Results: We identified 16 cases with ductus venosus agenesis. The type of DVA (intrahepatic-extrahepatic shunt), presence of chromosomal anomalies, accompanying ultrasonographic findings, and perinatal outcomes were recorded. Generally, in 7 out of the 16 cases, the umbilical vein drained into the portal system (44% - intrahepatic), and in 9 cases, it drained into the systemic venous system.
Conclusion: DVA is a rare congenital abnormality with potentially significant implications for affected fetuses and infants. Early diagnosis, careful monitoring, and appropriate management strategies are crucial to optimize outcomes for these patients. There's a need for future research to better understand the underlying etiology and pathophysiology of DVA and to develop more effective treatment options for affected individuals.
The effect of anti-phospholipid syndrome on pregnancy outcomes in patients with habitual abortus
Authors: Togay Alper , Tekin Duygu , Özer Mehmet , Kılınç Gönüllü Özden Sıla 
Published: September 2023

Objective: The aim of this study was to research the pregnancy outcomes of women with anti-beta2 glycoprotein 1 and anti-cardiolipin antibody positivity and to determine the association with pregnancy morbidity.
Materials and methods: This retrospective study contained pregnant women with anti-beta2 glycoprotein 1 and anti-cardiolipin antibody positivity and a control group without these antibodies. Totally 190 serum samples sent from Obstetrics and Gynecology clinics between January 2019 and January 2023 were analyzed in the medical microbiology laboratory of xx.
Results: In a patient population separated into antibody-positive and antibody-negative groups, the gravida was found to be 3.8±0.1 and 3.5±0.3 respectively (p=0.333). Parity was 1.1±0.1 and 0.8±0.1 (p=0.071), abortion rates were 2.3±0.1 and 2.5±0.2 (p=0.659), and gestational age was 35.7±0.8 and 34±1.5 (p=0.047). Intrauterine fetal death was found to be higher in the antibody-positive group compared to the antibody-negative group (p=0.03). There was no noteworthy distinction noted between the two groups regarding additional pregnancy complications such as intrauterine growth restriction, oligohydramnios, gestational diabetes, and gestational hypertension (respectively p=0.623, 0.074, 0.312, 0.626). However, smoking was significantly higher in the antibody-positive group (p=0.049).
Conclusion: Antiphospholipid syndrome adversely affects pregnancy outcomes. During the initial visit, a thorough patient history should be obtained, and in pregnant women with a history of poor obstetric outcomes or habitual abortions, this syndrome should be considered.
Evaluation of maternal and neonatal outcomes of emergency cesarean deliveries in cases of placenta previa uncomplicated with placenta acreata spectrum
Authors: Özer Mehmet , Özer Pınar Tuğçe , İleri Alper , Sever Barış , Aldemir Onur , Genç Funda , Balcı Mücahit Furkan , Pala Gürsoy 
Published: September 2023

Objective: The management and surgery of placenta previa describe a challenging process that requires experience. It is important to decide on the timing of planned cesarean section in women with placenta previa, taking into account the balance between possible maternal severe bleeding and possible neonatal morbidities.
Material and methods: In the present study, the data of 349 singleton pregnant women with a diagnosis of placenta previa uncomplicated by placenta accreta spectrum were analyzed. Patients who underwent planned (68%, n=236) or emergency cesarean section (32%, n=113) were divided into two groups. In this study, maternal demographic and clinical information, surgical procedures and maternal/neonatal outcomes were studied.
Results: The proportion of patients who underwent uterine compression suture and Bakri balloon was found to be significantly higher in the emergency cesarean section group compared to the planned cesarean deliveries group (p<0.001). The operation time, hospital stay, urinary tract infection rate, decrease in hemoglobin and need for blood transfusion were found to be significantly higher in the emergency cesarean section group compared to the planned cesarean section group (p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, respectively). In addition, a significant association was detected between emergency cesarean section and prematurity, low birth weight, low APGAR score, increased neonatal intensive care unit hospitalization and neonatal mortality.
Conclusion: Cases of placenta previa are at risk of emergency cesarean delivery, which can be complicated by poor maternal and neonatal outcomes. Equipped centers and experienced teams are of great importance in reducing fetomaternal morbidity and mortality caused by placenta previa.
Ce que la préhistoire fait à la théologie
Authors: Grosos Philippe 
Published: September 2023

L’œuvre du père Teilhard de Chardin est exemplaire de ce que l’introduction de la question préhistorique fait aux sciences humaines lorsqu’elle s’introduit en leur champ disciplinaire : elle les met dans l’obligation ou de se reformuler ou d’être en porte-à-faux avec la science de leur temps. Aussi la vertu première de l’œuvre de Teilhard, au-delà même des thèses qu’il a pu soutenir, est d’avoir été, sinon le premier, du moins un des premiers hommes d’Église, à envisager une théologie qui en prenne acte.
Teilhard de Chardin théologien ?
Authors: Euvé François 
Published: September 2023

Pierre Teilhard de Chardin n’était pas théologien de profession, mais son œuvre a surtout été reçue – et parfois contestée – dans le domaine religieux. Il n’a pas prétendu proposer une réflexion systématique mais renouveler la pensée chrétienne pour la mettre en cohérence avec les connaissances scientifiques. C’est ainsi que la théologie doit devenir une recherche permanente. En dépit de quelques limites, en particulier sur la question du mal, sa pensée peut rester inspirante pour le travail du théologien. Dans le dialogue avec les sciences, c’est une « nouvelle face de Dieu » qui se révèle.
Le christianisme sans histoire
Authors: Feneuil Anthony 
Published: September 2023

Le christianisme est-il essentiellement lié à l’histoire, au sens restreint de l’histoire enregistrée à partir du Néolithique ? Cet article montre que la pensée de Teilhard de Chardin offre une tentative de répondre « non » à cette question, en imaginant un christianisme sans histoire et dont la portée pourrait ainsi dépasser les limites de notre histoire. À partir de deux problèmes, celui de la préhistoire et celui de la vie extra-terrestre, et des questions qu’ils posent au christianisme, l’article décrit la manière dont Teilhard s’engage dans cette entreprise de reconfiguration des principaux concepts chrétiens pour les adapter à la fin du Néolithique et à la sortie de l’histoire humaine vers celle de l’Univers.
Impact of Feed Quality on Livestock Productivity
Authors: Baris Ahmet 
Published: September 2023

Abstract
Purpose: The aim of the study was to investigate impact of feed quality on livestock productivity.
Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.
Findings: High-quality feed rich in essential nutrients, such as protein and energy, plays a crucial role in enhancing the growth, reproduction, and overall health of livestock. Research consistently demonstrates that access to nutritious feed leads to increased weight gain in meat-producing animals, higher milk yields in dairy cattle, and improved reproductive performance in breeding stock. Conversely, poor-quality feed or inadequate nutrition can lead to stunted growth, lower milk production, reduced fertility, and increased susceptibility to diseases. Therefore, optimizing feed quality through proper nutrition management is a fundamental factor in maximizing livestock productivity and ensuring sustainable agricultural practices.
Unique Contribution to Theory, Practice and Policy: Nutrient Utilization Theory, Liebig's Law of the Minimum and Optimal Foraging Theory may be used to anchor future studies on impact of feed quality on livestock productivity. Livestock producers should implement stringent quality control measures to ensure the consistency and safety of animal feeds. Government agencies and industry associations can develop educational programs and training initiatives for livestock farmers.
Planned home birth in low-risk pregnancies
Authors: Sakuntari Made Diah Vendita , I Nyoman Hariyasa Sanjaya  , Pemayun Cokorda Istri Mirayani , Purwanti Ni Wayan Dewi , Gianni Ni Putu Nining , Putri Ni Luh Made Diah Mas Cahyani , Pirgantari Ni Komang Anik , Satriani Ni Luh Md Dwi Laxmi , Mintariani Firsta Sesarina , Agustini Anak Agung Wahyu Putri , Astuti Ketut Widyani 
Published: September 2023

Introduction: Planned home births are often a safe option for low-risk pregnancies, according to prior studies. This study aims to ascertain the characteristics of planned home deliveries with skilled medical staff in low-risk pregnancies as well as the outcomes on mother and infant health in Denpasar, Bali.
Methods: The planned home births from 2010 to 2019 were examined in this study using a retrospective descriptive design. The study included all intended home deliveries, including those that required hospital transfers owing to difficulties. As many as 168 planned home births with private doctor assistance made up the study’s sample. Sociodemographic and clinical variables were both examined in this analysis.
Results: The mean age of the sample in this study was 32 years. The findings indicate that women planning a home delivery with a licensed doctor in low-risk pregnancies have a better likelihood of spontaneous vaginal birth and favorable outcomes for maternal health. Additionally, there is a reduced likelihood of hospital transfer (10%). Furthermore, evidence demonstrates that planned home births are typically linked to fetal wellbeing.
Conclusion: The majority of women gave birth between 38 and 40 weeks gestation. The majority of samples were deliveries were normal vaginal births. The main reasons for transfer were due to the arrested cervical dilation or the arrested progress of the fetal head.
Are Some Dialects of Punjabi at the Verge of Death? A Sociolinguistic Study of Awankari
Authors: Sultan Ameer , Umar Lubna , Mir Shahid Hussain 
Published: September 2023

The purpose of the study is to describe the low prestige feelings of Awankari dialect speakers. The Punjabi language has many dialects but Majhi is considered a standard dialect in Western Punjab. The other dialects like Potohari, Dhani, Shahpuri, Jatki, Ghebi have not achieved prestige and are still considered inferior by the speakers of central Punjab in Pakistan. They study aims to investigate why some people feel low about their dialects and discourage their children to speak their native languages and local dialect. The data was collected from seventy native speakers of Awankari including government servants, businessmen, students and women who have left their native towns and moved to big cities. The study was conducted in a small village Jaba in Tehsil Naushera, Soon Sakesser Valley, District Khushab where these people have gathered on a wedding ceremony. Their mother tongue was Awankari and the data was collected through interview. The paper concludes with speculation about the possible death of Awankari. It also identified the dire need of dialect documentation of Awankari to preserve the language and culture of Soon Sakesser Valley and other areas where people speak this variety of Lahndi.