bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study
Authors: Dobewall Henrik , Keltikangas-Järvinen Liisa , Marttila Saara , Mishra Pashupati P. , Saarinen Aino , Cloninger C. Robert , Zwir Igor , Kähönen Mika , Hurme Mikko , Raitakari Olli , Lehtimäki Terho , Hintsanen Mirka 
Published: April 2023

IntroductionHelping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current study examines whether epigenetic aging is a potential biological mechanism that explains the link between prosociality and longevity.MethodsWe used data from the Young Finns Study that follows six birth-cohorts from age 3–18 to 19–49. Trait-like compassion for others was measured with the Temperament and Character Inventory in the years 1997 and 2001. Epigenetic age acceleration and telomere length were measured with five DNA methylation (DNAm) indicators (DNAmAgeHorvath, IEAA_Hannum, EEAA_Hannum, DNAmPhenoAge, and DNAmTL) based on blood drawn in 2011. We controlled for sex, socioeconomic status in childhood and adulthood, and body-mass index.Results and discussionAn association between higher compassion in 1997 and a less accelerated DNAmPhenoAge, which builds on previous work on phenotypic aging, approached statistical significance in a sex-adjusted model (n = 1,030;b = −0.34;p = 0.050). Compassion in 1997 predicted less accelerated epigenetic aging over and above the control variables (n = 843;b = −0.47;p = 0.016). There was no relationship between compassion in 2001 (n = 1108/910) and any of the other four studied epigenetic aging indicators. High compassion for others might indeed influence whether an individual’s biological age is lower than their chronological age. The conducted robustness checks partially support this conclusion, yet cannot rule out that there might be a broader prosocial trait behind the findings. The observed associations are interesting but should be interpreted as weak requiring replication.
Quantifying the effects of cold waves on carbon monoxide poisoning: A time-stratified case-crossover study in Jinan, China
Authors: Wei Jinli , Ren Aifeng , Zhang Yingjian , Yin Yuanrong , Chu Nan , Ma Yiwen , Du Jipei , Cui Liangliang , Zhou Chengchao 
Published: April 2023

BackgroundPrevious studies have shown that carbon monoxide (CO) poisoning occurs mostly in winter and is associated with severe cold weather (e.g., ice storms, temperature drops). However, according to previous studies, the impact of low temperature on health has a delayed effect, and the existing research cannot fully reveal the delayed effect of cold waves on CO poisoning.ObjectivesThe purpose of this study is to analyze the temporal distribution of CO poisoning in Jinan and to explore the acute effect of cold waves on CO poisoning.MethodsWe collected emergency call data for CO poisoning in Jinan from 2013 to 2020 and used a time-stratified case-crossover design combined with a conditional logistic regression model to evaluate the impact of the cold wave day and lag 0–8 days on CO poisoning. In addition, 10 definitions of a cold wave were considered to evaluate the impact of different temperature thresholds and durations.ResultsDuring the study period, a total of 1,387 cases of CO poisoning in Jinan used the emergency call system, and more than 85% occurred in cold months. Our findings suggest that cold waves are associated with an increased risk of CO poisoning in Jinan. When P01, P05, and P10 (P01, P05, and P10 refer to the 1st, 5th, and 10th percentiles of the lowest temperature, respectively) were used as temperature thresholds for cold waves, the most significant effects (the maximum OR value, which refers to the risk of CO poisoning on cold wave days compared to other days) were 2.53 (95% CI:1.54, 4.16), 2.06 (95% CI:1.57, 2.7), and 1.49 (95% CI:1.27, 1.74), respectively.ConclusionCold waves are associated with an increased risk of CO poisoning, and the risk increases with lower temperature thresholds and longer cold wave durations. Cold wave warnings should be issued and corresponding protective policies should be formulated to reduce the potential risk of CO poisoning.
Operationalization of a multidimensional sex/gender concept for quantitative environmental health research and implementation in the KORA study: Results of the collaborative research project INGER
Authors: Kraus Ute , Jacke Katharina , Dandolo Lisa , Debiak Malgorzata , Fichter Sophie , Groth Katrin , Kolossa-Gehring Marike , Hartig Christina , Horstmann Sophie , Schneider Alexandra , Palm Kerstin , Bolte Gabriele 
Published: April 2023

BackgroundIn environmental health research, sex and gender are not yet adequately considered. There is a need to improve data collection in population-based environmental health studies by comprehensively surveying sex/gender-related aspects according to gender theoretical concepts. Thus, within the joint project INGER we developed a multidimensional sex/gender concept which we aimed to operationalize and to test the operationalization for feasibility.MethodsIn an iterative process, we created questionnaire modules which quantitatively captured the requirements of the INGER sex/gender concept. We deployed it in the KORA cohort (Cooperative Health Research in the Region of Augsburg, Germany) in 2019 and evaluated response and missing rates.ResultsThe individual sex/gender self-concept was surveyed via a two-step approach that asked for sex assigned at birth and the current sex/gender identity. Additionally, we used existing tools to query internalized sex/gender roles and externalized sex/gender expressions. Adapted to the KORA population, we asked for discrimination experiences and care and household activities contributing to explain structural sex/gender relations. Further intersectionality-related social categories (e.g., socio-economic position), lifestyle and psychosocial factors were covered through data available in KORA. We could not identify appropriate tools to assess the true biological sex, sexual orientation and ethnic/cultural identity, which have yet to be developed or improved. The response-rate was 71%, the evaluation of 3,743 questionnaires showed a low missing rate. Prevalence of marginalized groups regarding sex/gender identity and definable by experiences of discrimination was very low.ConclusionWe have shown how the multidimensional INGER sex/gender concept can be operationalized according to an European and North American understanding of sex/gender for use in quantitative research. The questionnaire modules proved feasible in an epidemiologic cohort study. Being a balancing act between theoretical concepts and its quantitative implementation our operationalization paves the way for an adequate consideration of sex/gender in environmental health research.
Variations in national surveillance reporting for Mpox virus: A comparative analysis in 32 countries
Authors: Panag Deepkanwar Singh , Jain Nityanand , Katagi Dimitra , De Jesus Cipriano Flores Gabriela , Silva Dutra Macedo Gabriela Dias , Rodrigo Díaz Villa Gonzalo , Yèche Mathieu , Velázquez Mérida Saydi Yusveni , Kapparath Sreerag , Sert Zilfi , Reinis Aigars 
Published: April 2023

ObjectivesCase Reporting and Surveillance (CRS) are crucial to combat the global spread of the Monkeypox virus (Mpox). To support CRS, the World Health Organization (WHO) has released standardized case definitions for suspected, probable, confirmed, and discarded cases. However, these definitions are often subject to localized adaptations by countries leading to heterogeneity in the collected data. Herein, we compared the differences in Mpox case definitions in 32 countries that collectively reported 96% of the global Mpox caseload.MethodsWe extracted information regarding Mpox case definitions issued by the competent authorities in 32 included countries for suspected, probable, confirmed, and discarded cases. All data were gathered from online public sources.ResultsFor confirmed cases, 18 countries (56%) followed WHO guidelines and tested for Mpox using species specific PCR and/or sequencing. For probable and suspected cases, seven and eight countries, respectively were found to have not released definitions in their national documentations. Furthermore, none of the countries completely matched WHO’s criteria for probable and suspected cases. Overlapping amalgamations of the criteria were frequently noticed. Regarding discarded cases, only 13 countries (41%) reported definitions, with only two countries (6%) having definition consistent with WHO guidelines. For case reporting, 12 countries (38%) were found to report both probable and confirmed cases, in line with WHO requirements.ConclusionThe heterogeneity in case definitions and reporting highlights the pressing need for homogenization in implementation of these guidelines. Homogenization would drastically improve data quality and aid data-scientists, epidemiologists, and clinicians to better understand and model the true disease burden in the society, followed by formulation and implementation of targeted interventions to curb the virus spread.
Utility of video-assisted method for identifying and preserving the external branch of the superior laryngeal nerve during thyroidectomy
Authors: Ding Zhaoming , Sheng Ruinan , Zhang Liang , Han Jihua , Chen Mengshi , Bi Wen , Zhao Xuesong , Zhang Jiewu , Nie Chunlei 
Published: April 2023

BackgroundThe EBSLN is vulnerable to damage during thyroidectomy, results in voice related complications, negatively affect patient quality of life, routine identification of the EBSLN prior to surgical manipulation is necessary for a complication-free thyroidectomy. We aimed to validate a video-assisted procedure for identifying and preserving the external branch of the superior laryngeal nerve (EBSLN) during thyroidectomy and analyze the EBSLN Cernea classification and the localization of the nerve entry point (NEP) from the insertion of the sternothyroid muscle.MethodsA prospective descriptive study was performed; 134 patients, who scheduled for lobectomy with an intraglandular tumor max diameter ≤ 4 cm and without extrathyroidal extension, were randomly divided into the video-assisted surgery (VAS) and conventional open surgery (COS) groups. We used the video-assisted surgical procedure for visually identifying the EBSLN directly, and compared the differences in the visual identification rate and total identification rate of the two groups. We also measured the localization of the NEP using the insertion of the sternothyroid muscle as a reference.ResultsThere was no statistically significant difference in clinical characteristics between the two groups. The visual identification rate and total identification rate were significantly higher in the VAS group than the COS group (91.04% vs. 77.61%, 100% vs. 89.6%). The EBSLN injury rate was 0 in both groups. The mean vertical distance (VD) of the NEP from the sternal thyroid insertion was 1.18 mm (SD 1.12 mm, range, 0–5 mm), with approximately 88.97% of the results occurring within the 0–2 mm range. The mean horizontal distance (HD) was 9.33 mm (SD 5.03 mm, range, 0–30 mm), with over 92.13% of the results occurring within the 5–15 mm range.ConclusionBoth the visual and total identification rates of the EBSLN were significantly higher in the VAS group. This method provided a good visual exposure rate of the EBSLN, aiding in identifying and protecting the EBSLN during thyroidectomy.
B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles
Authors: Hiéronimus Léa , Huaux François 
Published: April 2023

Since their discovery nearly 40 years ago, B-1 cells have continued to challenge the boundaries between innate and adaptive immunity, as well as myeloid and lymphoid functions. This B-cell subset ensures early immunity in neonates before the development of conventional B (B-2) cells and respond to immune injuries throughout life. B-1 cells are multifaceted and serve as natural- and induced-antibody-producing cells, phagocytic cells, antigen-presenting cells, and anti-/pro-inflammatory cytokine-releasing cells. This review retraces the origin of B-1 cells and their different roles in homeostatic and infectious conditions before focusing on pollutants comprising contact-sensitivity-inducing chemicals, endocrine disruptors, aryl hydrocarbon receptor (AHR) ligands, and reactive particles.
Identification and validation of molecular subtype and prognostic signature for lung adenocarcinoma based on neutrophil extracellular traps
Authors: Zuo Yanhua , Leng Guangyi , Leng Ping 
Published: April 2023

Background: Neutrophil Extracellular Traps (NETs) are fibrous networks made of DNA-histone complexes and proteins protruded from activated neutrophils. Accumulating evidences have highlighted the vital role of NETs in tumor progression and diffusion. However, limited systematic studies regarding the role of NETs in LUAD have been performed.Methods: Differentially expressed NETs-related genes and their mutation landscape were identified with TCGA database. Consensus clustering analysis was performed to determine the NETs-related subtypes of LUAD. LASSO algorithm was employed to construct a prognostic signature. Moreover, GSE30219 and GSE31210 were used as independent validation. We also constructed a lncRNA-miRNA-mRNA regulatory axis with several miRNA and lncRNA databases.Results: Consensus clustering identified two NETs-related clusters in LUAD. High NETs score was correlated with a favorable overall survival, abundant immune cell infiltration, and high activity of immune response signal pathways. Six NET-related genes (G0S2, KCNJ15, S100A12, AKT2, CTSG, and HMGB1) with significant prognostic value were screened to develop a prognostic signature. LUAD patients with low-risk had a significantly favorable overall survival both in the training set and validation set. Moreover, NETs-related risk score and clinical stage could act as an independent prognostic factor for LUAD patients. Significant correlation was obtained between risk score and tumor immune microenvironment. We also identified lncRNA BCYRN1/miR-3664-5p/CTSG regulatory axis that may be involved in the progression of LUAD.Conclusion: We developed two molecular subtypes and a prognostic signature for LUAD based on NETs-related genes. This stratification could provide more evidences for estimating the prognosis and immunotherapy of LAUD patients.
Microbial Communities as Affected by Clarithromycin Addition in Four Acid Soils (NW Iberian Peninsula)
Authors: Rodríguez-González Laura , García-Campos Elena , Martín Ángela , Díaz-Raviña Montserrat , Arias-Estévez Manuel , Fernández-Calviño David , Santás-Miguel Vanesa 
Published: April 2023

A laboratory experiment was carried out to investigate the response of the microbial communities in acid agricultural soils located in the NW Iberian Peninsula to the presence of clarithromycin. Four soils, with different organic C content and similar pH, and seven different concentrations of clarithromycin (0.49, 1.95, 7.81, 31.25, 125, 500 and 2,000 mg kg−1 of soil) were used, and microbial estimates were made after 8 and 42 incubation days. The phospholipid fatty acids (PLFA) technique was used to estimate the total microbial biomass and biomass of specific microbial groups as well as the microbial community structure (PLFA pattern). The microbial biomass (total and specific groups) was different in the four studied soils, the lowest values being exhibited by soils with the lowest organic C. The antibiotic addition showed a positive effect on microbial biomass (total and specific groups), especially at the highest dose; the effect being similar or even more accentuated with time passed after the addition (42 days ≥8 days). Principal component analysis (PCA) of the PLFA data carried out with the whole data set showed that the main determining factors of the microbial structure followed the order: soil &gt; time incubation ≥ antibiotic dose. When the PCA was performed individually for each incubation time, the results indicated that microbial communities of the four soils were different. Likewise, for each soil, different microbial communities were observed depending on antibiotic concentration. The microbial biomass and PLFA pattern data were coincidentally showing that the clarithromycin addition favored fungi and G− bacteria more that bacteria and G+ bacteria; the effect being dose-dependent. Our data (microbial biomass, PLFA pattern) also demonstrated that the effect of clarithromycin addition on microbial communities in these four acid agricultural soils persisted even after 42 incubation days.
Analisis Yuridis Implementasi Peran Badan Wakaf Indonesia dalam Pengelolaan dan Pengembangan Wakaf Perspektif Kemanusiaan
Authors: Partono Teguh 
Published: April 2023

Badan Wakaf Indonesia (BWI) dibentuk berdasarkan Pasal 47 Undang-Undang Nomor 41 Tahun 2004, BWI merupakan lembaga independen dalam melaksanakan tugasnya, melakukan pembinaan terhadap nazhir, mengelola dan mengembangkan harta benda wakaf. Penelitian ini akan menjelaskan: (1) Implementasi Peran BWI dalam Pengelolaan dan Pengembangan Wakaf dan, (2) Pertanggungjawaban BWI dalam pengelolaan dan pengembangan harta benda wakaf, dengan menggunakan pendekatan teori kelembagaan, regulasi dan kemanfaatan. Metode penelitian dilakukan melalui pendekatan yuridis normatif dari bahan kepustakaan menggunakan data sekunder berupa antara lain peraturan perundang-undangan tentang wakaf, putusan pengadilan, jurnal, peneliatan ilmiah tentang wakaf, buku-buku, surat kabar media online dan internet. kesimpulan dari penelitian adalah sebagai berikut; BAB III menjelaskan implementasi tentang tugas dan wewenang BWI. melakukan pembinaan terhadap nazhir, mengelola dan mengembangkan harta benda wakaf berskala nasional dan internasional; BAB IV, Pertanggungjawaban BWI dalam melaksanakan tugasnya bertanggung jawab kepada Presiden dilakukan melalui laporan tahunan yang disampaikan kepada menteri agama. BAB V. Kesimpulan: (1) tugas dan wewenang BWI adalah melakukan pembinaan terhadap nazhir, mengelola dan mengembangkan harta benda wakaf berskala nasional dan internasional, (2) BWI dalam melaksanakan tugasnya bertanggung jawab kepada Presiden dilakukan melalui laporan tahunan yang disampaikan kepada menteri agama. Untuk efektivitas BWI sebagai lembaga independen dalam menjalankan tugasnya memajukan perwakafan nasional, penulis memberikan saran-saran sebagai berikut: (1) Perlu dilakukan perubahan status kelembagaan BWI yang independen secara mandiri tanpa campur tangan dan/atau pengaruh kementerian agama, (2). Untuk menghindari tumpang tindih antara tugas dan kewenangan, BWI hanya bertugas sebagai badan pengawas saja tidak merangkap sebagai badan pelaksana.
Kinerja Entitas, Kebijakan Hutang dan Kepemilikan Saham terhadap Nilai Perusahaan
Authors: Magdalena Shinta Maria , Tjahjono Rudi Setiadi 
Published: April 2023

The purpose of this study was to obtain empirical evidence regarding the effect of the independent variables consist of Company’s performances factors relating to profitability, liquidity, dividend, firm size and debt policy factor and share ownership factos relating to managerial and institutional ownership on the dependent variable of firm value. In this study, the population used were non-financial companies listed on the Indonesia Stock Exchange during 2018 to 2020. The sample used in this study which is totalled of 62 companies listed on the Indonesia Stock Exchange. Sampling in this study using purposive sampling method with a total sample of 186 data. The data analysis used is using multiple regression and the data is processed using the SPSS application. The results of this study indicate that institutional ownership, profitability, and debt policy have influence on firm value. Meanwhile, liquidity, dividend, firm size and managerial ownership have no influence on firm value.
Pengaruh Price Discount, Visual Merchandising dan Positive Emotion terhadap Impulse Buying di Ramayana Department Store Yogyakarta
Authors: Afriany Arista Natia , Kurniawan Adi , Basri Anindita Imam 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pengaruh price discount, visual merchandising, dan positive emotion terhadap impulse buying di Ramayana Department Store Yogyakarta. Penelitian ini dilakukan di Ramayana Department Store Yogyakarta. Sampel yang digunakan di dalam penelitian ini sebanyak 80 responden dan menggunakan teknik non probability sampling dengan metode purposive sampling. Teknik analisis data menggunakan analisis regresi linier berganda, uji T (parsial), uji F (Bersama-sama), koefisien determinasi (R2).
Hasil penelitian ini membuktikan bahwa price discount berpengaruh positif dan signifikan dengan koefisien 0,138 dan signifikasi 0,015, variabel visual merchandising berpengaruh positif dan signifikan dengan koefisien 0,199 dan signifikasi 0,025, serta variabel positive emotion berpengaruh positif dan signifikansi dengan koefisien 0,455 dan signifikasi 0,001. Hasil penelitian dari 3 variabel, mereka secara bersama-sama berpengaruh terhadap impulse buying dengan sig 0,000 < 0,05. Koefisien determinasi dalam penelitian ini adalah 34,2%.
Pengaruh Etnosentrisme Konsumen pada Preferensi Konsumen Studi: Perbandingan Preferensi Konsumen WNI Keturunan India pada Produk Bercorak India Dibanding Produk Bercorak Non-India
Authors: Febriani Reza , Parmono V. Rachmadi 
Published: April 2023

This study discusses the extent of consumer preferences of Indonesian citizens of Indian descent in Indian-patterned products compared to non-Indian-patterned products. This study aims to determine the preference of Indonesian consumers of Indian descent in Indian-patterned products compared to non-Indian patterns. This research uses quantitative methods. The method used to obtain primary data by disseminating it directly to Indonesian citizens of Indian descent. The collected d ata were analyzed by analysis of mean, crosstab , and regression analysis. Based on the data analysis that has been carried out, the results of the study obtained several findings as follows. Based on regression analysis, ethnocentrism affects consumer preferences. Based on Analysis Chi Square, ethnocentrism has no relation to respondents' age, gender, income, education, or occupation
أثر عقيـدة أوباما على تراجع الاهتمام الأمريكـي في الشـرق الأوسـط والتوجه نحو آسيا والمحيط الهادي: دراسة في خطابات حالة الاتحاد 2008 – 2016
Authors: هياجنة عدنان , المصلح الدانة 
Published: April 2023

قدمت الدراسة محاولة علمية؛ لاختبار أثر عقيدة أوباما على السياسة الخارجية الأمريكية، تجاه منطقة الشرق الأوسط، وخاصة تراجع الاهتمام الأمريكي فيها، والانتقال إلى آسيا والمحيط الهادي، بالاعتماد على تحليل مضمون خطابات حالة الاتحاد خلال فترة توليه الرئاسة 2008 – 2016؛ من أجل تطوير منهج علمي لدراسة السياسة الخارجية الأمريكية، بالاعتماد على التصريحات الرسمية، وربطها بالأفعال والزيارات؛ لقياس تحولات وتوجهات هذه السياسة، التي قد يسهم تطبيقها في دراسة سياسة أي رئيس أمريكي؛ من أجل الوصول إلى نتائج علمية محايدة غير انتقائية، تتجاوز التركيز على نظريات محددة في مستويات التحليل في علم العلاقات الدولية.
وتعود أهمية الدراسة إلى ما تركته هذه السياسة من آثار على المنطقة، خاصة بعد وصول بايدن للحكم، حيث من المرجح أن يقوم بإحياء كامل لعقيدة أوباما. وخلصت الدراسة إلى أن عقيدة أوباما تقوم على العناصر الآتية: القيادة من الخلف، والصبر الاستراتيجي، ومبدأ القوة الذكية، والتعاون الأممي، وتقليص عدد القوات الأمريكية في المنطقة، من خلال المؤشرات التي تم رصدها في خطابات حالة الاتحاد. وانعكست هذه العقيدة على تراجع الاهتمام الأمريكي في الشرق الأوسط؛ حيث شهدت السياسة الخارجية الأمريكية سياسة إعادة التوازن، والتوجه نحو آسيا والمحيط الهادي، وعقد التحالفات والشراكات الاقتصادية؛ لما تمثله الصين من تحدٍّ للهيمنة الأمريكية - حسب ما تشير إليه المدرسة الواقعية الجديدة