bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Antibacterial of Leaf Sirih Merah Against Enterococcus Faecalis ATCC 29212 Bacteria
Authors: Yuliana Trisna , Meliani Devi , Kurnia Dikdik 
Published: January 2025

Background:
Dental root canal failure is a disease caused by gram-positive bacteria,
Enterococcus faecalis. The disease is caused by the bacterial cell wall consisting of a peptidoglycan
layer that protects the bacteria from internal osmotic pressure. Peptidoglycan biosynthesis
includes many enzymes, such as MurA, Penicillin-binding protein (PBP), and SrtA. Herbal
plants are a source of bioactive compounds, including antibacterial agents. There is information
that red betel leaves, also known as Piper crocatum, contain active substances such as
flavonoids, terpenoids, and steroids. However, there is no additional information on the antibacterial
properties of P. crocatum and the molecular mechanisms that affect the cell wall of E. faecalis
ATCC 29212 bacteria.

Objective:
This study aims to determine the antibacterial activity of the extract in vitro, screen
and study the antibacterial compounds of red betel leaves against oral pathogenic bacteria, namely
E.faecalis ATCC 29212 through molecular docking.

Methods:
The n-hexan:ea (9:1) fraction of P. crocatum extract was tested for inhibition zones
against E. faecalis ATCC 29212 bacteria, fractions that had positive results were then identified
using the LC-MS method. The LC-MS resulting compounds were tested using In Silico.

Results:
Antibacterial in the n-hexane: ethyl acetate (9:1) fraction of Red Betel Leaf has the best
concentration of 10% with a moderate inhibition zone category. LC-MS test results identified compounds
including Longicamphenylone, m/z 207, Nootkatone m/z 219, and Tridecanal m/z 221. Molecular
interactions between these compounds with target proteins, namely MurA, PBP, and SrtA,
show lower binding affinity values than natural ligands and positive controls for each protein.

Conclusion:
Nootkatone compounds demonstrated potential as MurA and PBP inhibitors, while
Longicamphenylone compounds showed potential as SrtA inhibitors. Both compounds have the
potential to inhibit peptidoglycan biosynthesis and bacterial cell wall formation through docking
simulations.

other:
So that both compounds have the potential to inhibit peptidoglycan biosynthesis and bacterial cell wall formation through docking simulations.
Fe3O4-viral-like Mesoporous Silica Nanoparticle(Fe3O4-vMSN)-Sustained Release of Lenvatinib for Targeted Treatment of Hepatocellular Carcinoma
Authors: Wang Xue , Xu Tianzhao , Song Hui , Zhou Lanmei , Li Xinyi , Li Guangli , Liu Xinghui 
Published: January 2025

Background:
Lenvatinib is an oral tyrosine kinase inhibitor that selectively inhib-its receptors involved in tumor angiogenesis and tumor growth. It is an emerging first-line treatment agent for hepatocellular carcinoma (HCC). However, there is no intravenous ad-ministration of Lenvatinib.

Aims:
This study aimed to construct nanocomposites that can efficiently support Lenvatinib and target liver cancer tissues and cells.

Objective:
In this study, ferric oxide-viral-like mesoporous silica nanoparticles-folic acid (Fe3O4-vMSN-FA) nanocomposites loaded with Lenvatinib were constructed, and their anti-hepatocellular carcinoma effects were evaluated.

Methods:
The hydrothermal method was used to synthesize ferric oxide (Fe3O4). Ferric ox-ide-viral-like mesoporous silica nanoparticles (Fe3O4-vMSN) were synthesized using a two-phase method. Then, Fe3O4-vMSN was modified with folic acid (Fe3O4-vMSN-FA) to better target tumor cells.

Results:
The experimental data showed that Fe3O4-vMSN-FA nanocomposites were suc-cessfully synthesized and could be loaded with Lenvatinib (Len@ Fe3O4-vMSN-FA). Fe3O4-vMSN-FA had good stability and biocompatibility, and it can release the loaded Len-vatinib faster in an acidic environment (pH 5.5). CCK8 assay and flow cytometry showed that HepG2 cells in the Len@ Fe3O4-vMSN group had the lowest cell viability and the high-est apoptosis rate, confirming the anticancer properties of Len@ Fe3O4-vMSN-FA in vitro. In addition, transwell experiments showed that the migration and invasion ability of HepG2 cells in the Len@ Fe3O4-vMSN-FA group were significantly inhibited. In vivo fluorescence imaging in mice confirmed the enhanced tumor-targeting ability of Fe3O4-vMSN-FA. The tumor volume of the Len@ Fe3O4-vMSN-FA group was significantly reduced, and there was no significant effect on body weight. Moreover, serum liver function index (ALT and AST) and HE staining showed that Len@ Fe3O4-vMSN-FA did not cause obvious damage to organ tissue.

Conclusion:
Len@ Fe3O4-vMSN-FA has a good anti-liver cancer effect. Fe3O4-vMSN-FA can be used as an alternative platform for MSCs for drug delivery, providing more options for cancer therapy.
micro-RNA 451-a as a Circulating Biomarker for Neuroblastoma
Authors: Gupta Aditya Kumar , Ahmad Aijaz , Kakker Disha , Meena Jagdish Prasad , Majhi Ravi Kumar , Jan Ambreen , Seth Rachna , Iyer Venkateshawran , Mallick Saumyaranjan 
Published: January 2025

Introduction:
Micro ribonucleic acids (miRNAs) are small non-coding RNAs that
modulate the expression of various genes. They have an important role in cancer pathogenesis.
Differential expression of multiple miRNAs have been used as potential diagnostic and prognostic
markers.

Methods:
Various cancers have lately been employed as therapeutic targets. This prospective
study included untreated pediatric neuroblastoma (NB) patients. In the discovery phase, global
miRNA profiling was done using next-generation sequencing (NGS) on biopsy tissue samples of
NB patients. In this phase, the top expressing miRNA was identified and chosen for further validation
as circulating miRNA in blood samples of a different set of NB patients by real-time polymerase
chain reaction (PCR).

Results:
Based on the read counts on the global miRNA profiling in the discovery phase, we
found that the miRNA that consistently had high reads across the majority of the NB samples
were miRNA 451-a, 19b-3p, 106b-5p, and 21-5p. Of these, we selected miRNA 451-a and 19-b
for the validation phase of the study as they had consistent overexpression. In the validation
phase, the expression of the circulating miRNA 451-a in the blood was found to be higher. The
average value for the relative fold (RF) expression for miRNA 451-a was 1.52.

Conclusion:
miRNA 451-a is overexpressed both in the cancer tissue and the blood of NB patients.
It can serve as a potential diagnostic marker. Further studies can elucidate its role in the
pathogenesis of NB and it can have utility as a therapeutic target.
More Cyberbullying, Less Happiness, and More Injustice—Psychological Changes During the Pericyberbullying Period: Quantitative Study Based on Social Media Data
Authors: Liu Xingyun , Liu Miao , Kang Xin , Han Nuo , Liao Yuehan , Ren Zhihong 
Published: January 2025

Background
The phenomenon of cyberbullying is becoming increasingly severe, and many studies focus on the negative psychological impacts of cyberbullying survivors. However, current survey methods cannot provide direct and reliable evidence of the short-term psychological effects of cyberbullying survivors, as it is impractical to measure psychological changes before and after such an unpredictable event in a short period.

Objective
This study aims to explore the psychological impacts of cyberbullying on survivors during the pericyberbullying period, defined as the critical time frame surrounding the first cyberbullying incident, encompassing the psychological changes before, during, and after the event.

Methods
We collected samples from 60 cyberbullying survivors (experimental group, 94/120, 78% female) and 60 individuals who have not experienced cyberbullying (control group, matched by sex, location, and number of followers) on Sina Weibo, a social media platform developed by Sina Corporation. During the pericyberbullying period, we retrospectively measured psychological traits 3 months before and after the first cyberbullying incident for both groups. Social media data and predictive models were used to identify survivors’ internal psychological traits, including happiness, suicide risk, personality traits, and moral perceptions of the external environment. Network analysis was then performed to explore the interplay between cyberbullying experiences and psychological characteristics.

Results
During the pericyberbullying period, survivors exhibited significantly reduced happiness (t59=2.14; P=.04), marginally increased suicide risk, and significant changes in the Big 5 personality traits, including decreased conscientiousness (t59=2.27; P=.03), agreeableness (t59=2.79; P=.007), and extraversion (t59=2.26; P=.03), alongside increased neuroticism (t59=–3.42; P=.001). Regarding moral perceptions of the external environment, survivors showed significant increases in communicative moral motivation (t59=–2.62; P=.011) and FairnessVice (t59=–2.20; P=.03), with a marginal rise in PurityVice (t59=–1.88; P=.07). In contrast, the control group exhibited no significant changes during the same time frame. Additionally, network analysis revealed that beyond cyberbullying experiences, core psychological characteristics in the network were neuroticism, conscientiousness, and Oxford Happiness.

Conclusions
By leveraging noninvasive retrospective social media data, this study provides novel insights into the short-term psychological impacts of cyberbullying during the pericyberbullying period. The findings highlight the need for timely interventions focusing on enhancing survivors’ happiness, reducing suicide risk, adjusting personality traits, and rebuilding moral cognition to mitigate the negative effects of cyberbullying.
PENGHENTIAN PERKARA PENYALAHGUNAAN NARKOTIKA DI TINGKAT PENYIDIKAN BERDASARKAN KEADILAN RESTORATIF
Authors: Pratama Riza Chatias , Melissa Aldisa 
Published: January 2025

Tindak pidana narkotika menjadi salah satu kejahatan yang paling banyak terungkap di kota-kota di Indonesia. Narkoba (psikotropika, narkotika dan zat adiktif lainnya) tentunya menjadi suatu hal yang membahayakan kehidupan manusia jika dalam penggunaannya dilakukan dengan cara yang tidak benar, karena dapat menyebabkan ketergantungan dan bahkan dapat mengakibatkan over dose bagi pennggunanya. Penyalahgunaan narkotika yang saat ini terjadi, merupakan masalah global (dunia), dan tidak lagi hanya sebatas problematika daerah dan nasional di Indonesia. Penyalahgunaan narkotika telah menembus ruang publik bahkan dilakukan oleh laki-laki dan perempuan dengan tanpa adanya perdebatan gender, kelas ekonomi bahkan usia. Kecenderungan meningkatnya penyalahgunaan narkotika mengarah pada Tindakan kriminal yang dapat berujung pada sanksi pidana. Namun, saat ini penyelesaian tindak pidana penyalahgunaan narkotika tidak lagi hanya sebatas sanksi pidana bahkan upaya pemenjaraan pelaku. Setelah diterbitkannya Peraturan Kapolri Nomor 8 Tahun 2021 tentang Penanganan Tindak Pidana Berdasarkan Keadilan restoratif, maka penyelesaian kasus penyalahgunaan narkotika yang memenuhi kriteria seperti yang diatur dalam peraturan tersebut dapat diberikan sanksi tindakan berupa rehabilitasi. Penerapan peraturan kapolri tersebut di Wilayah Hukum Kepolisian Daerah Aceh sudah diterapkan dan telah berhasil menylesaikan 4 kasus penyalahgunaan narkotika melalui keadilan restoratif. Secara keseluruhan penerapan peraturan kapolri memang sudah baik namun belum efektif karena dari banyaknya kasus hanya jumlah kecil yang diselesaikan secara keadilan restoratif.
Use of nicotine vaping products during an attempt to quit smoking by Canadian adults who smoke or recently quit: findings from the 2022 Canada International Tobacco Control Four Country Smoking and Vaping Survey
Authors: Gravely Shannon , Sweanor David , Driezen Pete , Levy David T. , Fong Geoffrey T. , Quah Anne C. K. , Craig Lorraine V. , Chung-Hall Janet , Kaai Susan C. , Cummings K. Michael 
Published: January 2025

Abstract

An analysis of 1771 Canadian adults who smoke or used to smoke cigarettes was conducted using data from the 2022 International Tobacco Control Four Country Smoking and Vaping Survey. Using weighted data, we estimated the prevalence of Canadian adults who tried to quit smoking between 2020 and 2022, and the use of a nicotine vaping product (NVP) and the flavours and devices used most often at their most recent quit attempt. Overall, 36.5% made a quit attempt; of those, 19.4% used an NVP. Those who were younger and quit smoking were more likely to have used an NVP. Prefilled cartridges or pods (36.3%) and fruit flavours (39.5%) were used most frequently.
Modern Information and Communication Mechanisms for Adaptation of Foreign Labor Migrants in Russia
Authors: Boyarko A. G. 
Published: January 2025

Introduction. The article examines the existing mechanisms of adaptation of labor migrants in Russia. Based on the analysis of regulatory documents and the practice of implementing various solutions (from migrant cards to special information applications), conclusions are drawn about successes and shortcomings, and recommendations are given for the further development and improvement of these mechanisms.Materials and methods. The theoretical and methodological basis of the research is the works of domestic and foreign scientists, as well as reports and datasets from leading international organizations, in particular the International Organization for Migration (IOM) and the Advisory Committee on Migration Policy of the EEC. The work uses elements of the theory of digital communication, as well as classical theories of migration. In particular, the theories of Everett S.Lee, M. Prior, H.G. Duncan, V. Zelinsky and S.N. Eisenstadt used methods of induction, deduction, generalization, synthesis, and comparison to conduct system analysis.Research results. During the conducted research, an analysis of the regulatory framework was carried out, in particular, the provisions of Decree of the President of the Russian Federation dated October 31, 2018 No. 622 "On the Concept of the State Migration Policy of the Russian Federation for 2019-2025" (recent amendments and additions dated May 12, 2023)In addition, it was found that the main digital Mobile and Internet applications are the tools for the adaptation of migrants to Russian society. Among the most successful projects, it is worth noting the work of multifunctional centers and the creation of an electronic migrant card. It has been established that many tools do not work effectively enough. The main reasons are the complex legal language and the lack of translation, the applications are fragmented, there are no clear methodological instructions, there are regulatory and technical limitations.Discussion and conclusion. All the tools and resources used today for the adaptation of migrants in Russia operate separately. It is important to emphasize that increasing the number of platforms and applications will not solve the problem of effective use of digital technologies in this matter. It is necessary to create a network of quality resources linked to each other, each resource must provide a certain direction (legislative information, migrant status, access to services, etc.) so that when using them, a foreign citizen understands the relevance of the information provided and easily gets access to the services offered.
The Humanitarian Crisis in the Gaza Strip, its Impact on the Peace Process in the Middle East and the Humanitarian Sphere of World Politics
Authors: Rustamova L. R. 
Published: January 2025

Introduction. Humanitarian crises in the conflicts of recent decades directly affect the security of not only neighbouring states, but also undermine the established system of humanitarian cooperation between states. Non-state actors: terrorist organizations, separatist groups, protest movements, paramilitary religious groups and others that participate in conflicts and choose violent measures, complicate the resolution of conflicts. Despite the fact that all parties to the conflict are obliged to comply with the norms of international humanitarian law, both states and non-state actors are increasingly moving away from the principles of humane treatment of the civilian population. Each of the parties puts forward its own justifications for the indiscriminate approach.Materials and methods. The study is based on the case study method. An analysis of the changes in the provision of humanitarian aid to the civilian population during the humanitarian crisis in the Gaza Strip makes it possible to draw conclusions about the current trends in the development of the humanitarian sphere as a whole. The author used materials from Russian and foreign media, UN and INGO reports, and international treaties.Reseach results. The conflict complicated the peace process, normalization of relations between Israel and Arab states, and also exposed the problem of politicization of humanitarian aid. Politicization manifested itself not only in the assessment of the conflict itself, which has long divided the world community, but first of all, for the first time, it had such a large-scale impact on the UN humanitarian aid institutions and various INGOs. The politicization of the conflict also resulted in the manifestation of a "cancel culture", which stigmatized the parties to the conflict and complicated the activities of humanitarian organizations in providing assistance to the civilian population.Discussion and conclusion. However, the most serious consequences are not only in the area of worsening the humanitarian situation, threats to civilians and employees of intergovernmental and non-governmental organizations involved in providing humanitarian aid to the affected population, collecting information on the situation of civilians, the balance of power and compliance with international humanitarian law, but also in the area of compliance with the principles of humanitarian aid themselves. The humanitarian community is divided between those who support Israel's position and its stated "right to self-defense" and those who advocate for its accountability along with Hamas for what the UN SecretaryGeneral called "excessive use of force". An analysis of the impact of humanitarian crisis in the Gaza Strip on the process of conflict resolution is of great scientific interest, and its results can enrich knowledge not only about the peace process itself, but also about the role of humanitarian sphere in world politics.
The Particularities of Russian-Chinese Economic Cooperation at the Present Stage: Scientists and Society’s Opinions
Authors: Pomozova N. B. , Li Zhongyuan , Starikova E. A. , Dubovskaya A. V. 
Published: January 2025

Introduction. In the context of the transformation of the international relations system and the world's movement towards a multipolar structure, Russian-Chinese relations have received a new impetus for development. The confrontation with the Western countries has opened a window of opportunity for deepening economic cooperation between the two countries. Despite the growth in trade turnover recorded in 2023, there remain areas of partnership with significant potential. At the same time, one of the main problems facing Russian-Chinese cooperation at the present stage is the shortage of competent personnel and the low level of knowledge of Russians and Chinese about each other.The article presents the results of sociological surveys conducted among Chinese students and specialists, which revealed their attitude towards cooperation with Russia. The surveys showed that young Chinese are interested in the development of Russian-Chinese relations, especially in the field of infrastructure projects. The study, conducted by MGIMO with the support of the CITIC Foundation, Beijing Normal University and China’s University of International Relations, identified the most promising areas for cooperation between the two countries.The purpose of this article is to analyze the current state and prospects of bilateral economic cooperation in some areas based on the results of sociological surveys of Chinese citizens of various age groups. Materials and methods. In the course of the work, such methods of scientific knowledge as analysis, synthesis, generalization, analogy, induction, deduction, forecasting were used; sociological surveys were conducted. Foreign and Russian scientific articles, statistical data, and media publications devoted to various aspects of the development of bilateral projects between Russia and China were used as research materials.Research results. The analysis of the data obtained revealed that the majority of respondents consider infrastructure sectors to be the most promising for cooperation between the two countries, and public-private partnership (PPP) is perceived as an effective mechanism for implementing Russian-Chinese infrastructure projects.Discussion and conclusion. The study showed that in the face of Western pressure on Russia and China, the two countries should deepen economic cooperation. The transformation of the world order and the growing influence of developing countries create favorable conditions for increasing cooperation. Chinese youth are interested in joint projects in the fields of infrastructure, transport, energy, manufacturing, agriculture, science, and tourism. The key role in the success of such cooperation is played by the training of qualified personnel. It is necessary to develop not only trade and economic ties, but also cultural, social, scientific and educational relations.
Inclusive Education and the New Paradigms For Life in Society
Authors: Corrêa Shirlei De Souza , Moraes Marilú Aparecida Carlini De , Alves Cleide , Fortunato Daniele Jociane , Bolsan Denise 
Published: January 2025

Objective: The objective of this study is to understand how the inclusion processes in contemporary education have contributed to the paradigm shifts regarding life in society.

Theoretical Framework: The theoretical foundation is based on documents and legislation related to inclusion, such as the Salamanca Statement (1994), the Inclusion Law (2015), and authors like Pletsch et al. (2007), Mantoan (2026), and Nunes (2015). These authors indicate that over the last few decades, the understanding of the needs of people with disabilities has evolved, resulting in a new proposal for life in society, which directly reflects in school contexts and, particularly, in educational practices that were previously centered around a segregated system and selective integration.

Method: From a methodological standpoint, it is emphasized that the research was carried out through a bibliographical study of a qualitative nature. Following the methodological approach, several steps were taken, namely: selection of legislation related to Inclusive Education; selection of studies from the Scielo database between 2010 and 2024, focusing on the thematic of paradigm changes related to inclusive education; and, finally, a descriptive analysis of the collected material, in order to identify strengths and/or weaknesses related to the inclusion process.

Results and Discussion: The results indicate that many educational practices have been developed and are moving towards ensuring these rights, contributing to inclusion processes. In this sense, it is emphasized that the inclusion paradigm proposes the transformation of educational and social structures so that everyone can participate fully, regardless of their conditions.

Research Implications: The implications of this research draw attention to the fact that, although official documents aim to ensure rights, much still needs to be done, especially in the school context, to move beyond the mere inclusion of people with disabilities and, in fact, achieve true inclusion.

Originality/Value: This study allows for the exploration of complex issues that have increasingly been at the center of discussions regarding life in society, especially because discussions on inclusion go beyond school settings and reach the workplace, relationships, and all aspects of life in society.