bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frecuencia del trauma genitourinario en accidentes de tránsito en motocicleta: Revisión de alcance
Authors: Castañeda Millán Gabriela , Hernández Aparicio David Andrés , Castañeda Millán David , Eslava Schmalbach Javier Hernando 
Published: January 2025

Objetivo Describir la frecuencia del trauma genitourinario (TGU) causado por accidentes de tránsito en motocicleta.
Metodología Revisión de alcance de acuerdo con la metodología propuesta por Arksey y O´Malley y la extensión para revisiones de alcance Prisma. Las búsquedas se realizaron en PubMed y Embase. Se incluyeron todos los estudios que describieron la frecuencia del TGU en población adulta (≥ 18 años) como consecuencia de accidentes de tránsito en motocicleta. Dos revisores independientes se encargaron de la selección por título y resumen y posteriormente de la evaluacion de la elegibilidad y la calidad de los estudios en texto completo.
Resultados La frecuencia de TGU fue mayor en hombres, con cifras entre el 94,5% y el 96,5%, respecto a 3,4% y 5,5% en mujeres. Los conductores fueron los más afectados en comparación con los pasajeros, con una proporción de 96,4%. Los testículos fueron los principales órganos afectados, con frecuencias de trauma reportadas entre el 0,4% y el 41%, seguidos del riñón (2,4% a 35%); escroto (0% a 14%); pene (0% a 13%); vejiga (0,4% a 4%); uréter (0 a 0,02%); uretra (0,2% a 2%); vagina (1%) y vulva (1%).
Conclusión La frecuencia del TGU en pacientes involucrados en accidente de motocicleta es alta. Afecta con mayor frecuencia a los hombres jóvenes conductores de motocicleta; los órganos más afectados son los genitales externos masculinos, los riñones y la vejiga. No obstante, en mujeres, es una causa importante de TGU no obstétrico.
Development of an extracorporeal pump for ECMO systems
Authors: Kuleshov A. P. , Bogdanov V. K. , Grudinin N. V. , Buchnev A. S. , Esipova O. Yu. 
Published: January 2025

Objective: today, extracorporeal membrane oxygenation (ECMO) systems remain the main type of short-term circulatory support in various clinical situations. One of the main elements of this system is a blood pump. The objective of this study is to develop the first domestic centrifugal pump for use in ECMO systems.Materials and methods. Based on a systematic literature review, the main medical and technical requirements for an extracorporeal centrifugal pump were formulated. To create 3D mathematical models of the outer casing of the pump and all its internal components, calculations were performed in CAD software package SolidWorks (SolidWorks Corp., USA). Hydrodynamic test benches were designed and developed to evaluate the performance of the centrifugal pump mockup. The pump was studied to obtain its head-capacity curve (HCC) and hemolytic characteristics.Results. 3D modeling of geometrical parameters of the pump flow impeller was performed. Fluid flow was assessed in the rotor rotation range at speeds from 3000 to 7000 rpm. Hydrodynamic bench tests were performed under conditions simulating the resistance of the oxygenator and connecting cannulas. The HCC was obtained based on the given medical and technical requirements for the operating flow range from 1 to 5 l/min at pressure dropsof 200 to 400 mm Hg.Conclusion. Based on results from the 3D modeling and bench experiments, a model of extracorporeal centrifugal pump was obtained, which showed its efficiency during the first trials. Further experimental studies will be conducted to obtain the energy and biological characteristics of the developed device.
Single-center experience in kidney transplantation: outcomes, conclusions, and perspectives
Authors: Khubutia M. Sh. , Dmitriev I. V. , Balkarov A. G. , Anisimov Yu. A. , Shmarina N. V. , Zagorodnikova N. V. , Borovkova N. V. , Minina M. G. , Lonshakov D. V. , Aleksandrova V. O. , Smirnova V. , Rustambek A. U. 
Published: January 2025

Kidney transplantation (KT) remains the best treatment for patients with chronic kidney disease (CKD) stage 4–5. It helps patients live longer, have better quality of life, and undergo improved medical and social rehabilitation. This paper examines the outcomes of KT performed between 2019 and 2023.Materials and methods. There were 1,106 KTs deceased donor KTs performed between January 1, 2029, and December 31, 2023. The recipients had a median age of 45 (37–54) years, with 664 (60%) males and 442 (40%) females. Donors were mainly males (n = 706, 63.8%), with the median donor age being 50 (43–57) years. Induction immunosuppressive therapy (IST) with monoclonal antibodies was administered to 859 (77.7%) recipients, with polyclonal antibodies to 122 recipients (11%), and induction without antibodies to 125 recipients (11.3%). Triple-drug baseline IST consisted of a combination of calcineurin inhibitors, antimetabolites and glucocorticoids. Tacrolimus was the most often utilized calcineurin inhibitor (n = 961, 86.9%), while cyclosporine was used less often (n = 145, 13.1%). Mycophenolic acid (n = 1041, 94.1%) was used as the second medication in most recipients, while everolimus (n = 54, 4.9%) and azathioprine (n = 11, 1%) were used less often.Results. Primary initial renal graft function was noted in 714 patients (64.6%) and delayed in 392 recipients (35.4%). Overall incidence of surgical complications was 11.6% (n = 130), and immunological complications 9.9% (n = 109). At hospital discharge, 768 recipients (69.4%) had satisfactory kidney allograft (KAG) function, while 276 recipients (25%) were discharged with graft dysfunction; median serum creatinine and blood urea levels were 158 (120–204) μmol/L and 11 (8–16) mmol/L, respectively. Twenty-six recipients (2.4%) were discharged to continue renal replacement therapy; 28 recipients (2.6%) underwent in-hospital graft nephrectomy. Twelve individuals passed away during the hospitalization phase. The cumulative uncensored in-hospital graft and recipient survival rates were 97.5% (n = 1078) and 98.9% (n = 1094), respectively.Conclusion. KT is an effective and safe transplant modality for stage 4–5 CKD. Our KT outcomes are consistent with those of reputable transplant centers around the globe.
BIOLOGIA CELULAR EM LICENCIATURAS DE EDUCAÇÃO FÍSICA EM INSTITUIÇÕES PÚBLICAS
Authors: OLIVEIRA BRUNO BARROS DE , MEIRELES JOSÉ ROBERTO CARDOSO 
Published: January 2025

Introdução: O profissional de Educação Física é múltiplo, atuando inclusive em equipes multidisciplinares de programas de atenção à saúde. Assim, sua formação deve contemplar matérias básicas que lhe permita compreender a fisiologia humana. Dentre estas, a Biologia Celular constituí a base da fisiologia, anatomia e histologia, uma vez que em última análise a saúde depende das células. Objetivo: Analisar, através dos Projetos Políticos Pedagógicos de Cursos (PPPC), a abordagem da Biologia Celular em cursos de Licenciatura em Educação Física de Instituições de Ensino Superior públicas brasileiras. Métodos: Através de pesquisa qualitativa documental, analisou-se nos PPPC (1) a oferta da disciplina de Biologia Celular e/ou disciplinas que com conteúdos relacionados a Biologia Celular (carga horária total), (2) o período do curso em que a disciplina é indicada, (3) natureza (obrigatória ou optativa), (4) a metodologia (prática e/ou teórica e/ou extensão com respectiva carga horária) e (5) os conteúdos abordados. Resultados: De 59 PPPC analisados observou-se que a disciplina de Biologia Celular é oferecida em apenas seis dos cursos (cerca de apenas 10 %). Neste a matéria tem carga horária muito variada (de 30 h a 97 75 h) e conteúdos extensos que na maioria não está de acordo com a carga horária. Conclusão: É preciso uma revisão nos currículos para a inserção do estudo da célula, uma vez que esta estrutura é a base dos tecidos, órgãos e sistemas do corpo humano. Isto contribuiria para uma formação mais sólida dos educadores físicos para atuar na área da saúde.
Białka ulegające separacji faz u roślin i metody ich badań
Authors: Gapińska Marta 
Published: January 2025

Numerous scientific reports in recent years have indicated that liquid-liquid phase separation (LLPS) is an important mechanism allowing plants to identify various biotic and abiotic stresses and respond to them. The following paper reviews the methods currently used to study macromolecular condensates and the function of proteins undergoing LLPS in plants.
La fórmula del suspenso.....
Authors: Pita César 
Published: January 2025

...consiste en no ocultar lo evidente y a pesar de ello desatar la sorpresa. El espectador admite el engaño y renueva la confianza en el director, quien a estas alturas se revela como un mago de la narración. Mejor aún: burla sin cortapisas la censura y dicta una clase maestra de ritmo cinematográfico. En el colmo de la prestidigitación, se da maña para evidenciar su sello al anteponer su nombre al título de la película o cuando aparece en pantalla en el momento menos esperado, como si fuera parte de la puesta en escena que construye. Ese es el arte de Alfred Hitchcock, a quien dedicamos el dossier de la presente edición de CineScrúpulos, plagada además de otros momentos interesantes.
EPAGOGIJA I PROBLEM RELACIONIZMA U PLATONOVOM HIPIJI VEĆEM
Authors: DRAŠKIĆ VIĆANOVIĆ IVA 
Published: January 2025

Tema teksta je koncepcija lepote u Platonovom Hipiji Većem. Autor analizira sve definicije lepote koje su ponuđene u dijalogu i kao ključnu metodu prepoznaje epagogiju koja se odvija u dva smera: prvi – kroz predmete, objektivno i stiže do prikladnosti (prepon) kao određenja lepote, što podrazumeva relaciju prema svrsi, dakle relacionizam, a samim tim, u Platonovom misaonom sistemu i relativizam; drugi smer epagogije je ka subjektivnoj svesti, odakle proizlazi definicija lepote kao onoga što donosi zadovoljstvo čulima, što opet znači uspostavljanje relacije, ovog puta prema čovekovoj čulnosti, odnosno svesti; Relacionizam se pojavljuje ponovo implicirajući opet, neizbežno, relativizam. Prema autorovom mišljenju, upravo to je razlog Platonovog odustajanja – kada je lepota u pitanju – od načina istraživanja i metodskog postupka preduzetog u ovom njegovom ranom dijalogu.
Gaya Bahasa Asonansi dan Aliterasi pada Q.S At-Takwir Juz 30: Kajian Fonologi Fungsional Estetik
Authors: Latifah Umi , Badrih Moh. 
Published: January 2025

The focus of this research to analyzing patterns of the purpose of this study is to identify and analyze the patterns of assonance and alliteration in Q.S. At-Takwir, to understand how these phonological elements contribute to the aesthetic beauty and strengthen the meaning of the theological message contained in the surah. The research method used is a qualitative approach with a descriptive-analytical method. The data in this study are in the form of the text of Q.S. At-Takwir from the Qur'an. The stages of data analysis include data collection, identification and categorization, phonological analysis, data interpretation, drawing conclusions, and data validation. The results show that assonance creates a deep emotional atmosphere and strengthens the message, while alliteration adds rhythm, deepening the dramatic effect. Assonance and alliteration in Q.S. At-Takwir play an important role in beautifying the text, building rhythm, and strengthening the theology of the message, indicating that these phonological elements function more than just aesthetics, but as a means of conveying a deep spiritual message.
Teaching About and For Social Justice
Authors: Robertson Joanne , Sivia Awneet 
Published: January 2025

Teaching for social justice is an explicit goal of most teacher education programs. However, this mandate has been criticized by scholars who claim that social justice is an undertheorized and vague concept that is often disconnected from methods courses that focus on content-specific pedagogies. This study seeks to address this disconnect by exploring how an Equity Literature Circles (ELC) framework within a literacy methods course can enhance teacher candidates’ (TCs’) understanding of the relationship between literacy instruction, diversity, and social justice. Drawing on the perceptions of ten TCs enrolled in a teacher education program in western Canada, data for the study was generated from classroom artifacts, an individual survey, and a focus group interview. Upon analysis of the data, the findings suggest that an ELC framework is an effective instructional strategy for enhancing TCs’ understanding of intersecting aspects of diversity, equity-focused literacy instruction, and teaching about and for social justice.

Teaching for social justice is an explicit goal of most teacher education programs. However, this mandate has been criticized by scholars who claim that social justice is an undertheorized and vague concept that is often disconnected from methods courses that focus on content-specific pedagogies. This study seeks to address this disconnect by exploring how an Equity Literature Circles (ELC) framework within a literacy methods course can enhance teacher candidates’ (TCs’) understanding of the relationship between literacy instruction, diversity, and social justice. Drawing on the perceptions of ten TCs enrolled in a teacher education program in western Canada, data for the study was generated from classroom artifacts, an individual survey, and a focus group interview. Upon analysis of the data, the findings suggest that an ELC framework is an effective instructional strategy for enhancing TCs’ understanding of intersecting aspects of diversity, equity-focused literacy instruction, and teaching about and for social justice.
POTENSI EKSTRAK JINTAN HITAM (Nigella sativa) SEBAGAI KANDIDAT TERAPI KOMPLEMENTER DIABETES MELITUS
Authors: Fary Kevin Zufaris , Simanjuntak Evi Christina Madalena , Simanjuntak Evi Christina Madalena , Marhadhani Syifa Fatimatuzzahra , Azzahra Aurora , Oktaviana Husnul Afifah Rizky , Putri Iqfani Amalia , Daffa Mochamad Zidqi , Setiawati Setiawati 
Published: January 2025

Diabetes melitus merupakan penyakit metabolik dengan peningkatan glukosa dalam darah dengan ketidakmampuan sel β pankreas menghasilkan insulin maupun penurunan efektivitas penggunaan insulin. Perawatan utama Diabetes Melitus (DM) adalah terapi konvensional dengan menggunakan obat hipoglikemik oral dan terapi injeksi insulin. Masyarakat juga menggunakan pengobatan tradisional karena dianggap memiliki efek samping minimal. Jintan hitam (Nigella sativa) merupakan salah satu tanaman herbal yang dapat digunakan untuk menurunkan kadar gula darah. Penelitian ini bertujuan untuk mengetahui potensi manfaat dan dosis yang digunakan pada pengobatan diabetes melitus. Literature review ini diperoleh dengan hasil pencarian literatur melalui Pubmed dan Sciencedirect didapatkan 7(tujuh) jurnal penelitian eksperimental. Pemberian ekstrak jintan hitam (Nigella sativa) pada pasien diabetes melitus dapat menurunkan gula darah dengan efek hipoglikemik yang dimiliki dan sebanding dengan penggunaan metformin.

Kata kunci: diabetes melitus, metformin, Nigella sativa
ANALISIS KEAMANAN WEBSITE DENGAN INFORMATION SYSTEM SECURITY ASSESSMENT FRAMEWORK (ISSAF) DAN OPEN WEB APPLICATION SECURITY PROJECT (OWASP)
Authors: Nugroho Verseveranda Setyo , Christanto Febrian Wahyu 
Published: January 2025

Meningkatnya penggunaan platform digital dalam setiap kegiatan manusia memunculkan kembali perhatian yang pada dasarnya diperlukan di setiap aktifitas atau hal yang dikerjakan manusia, seperti keamanan. Keamanan juga tentu saja hadir dalam kegiatan yang sudah terdigitalisasi atau dapat disebut juga sebagai Cybersecurity. Keamanan dalam Cybersecurity penting karena berkaitan dengan data pribadi (Privacy), integritas (Integrity), akses atau verifikasi (Authentication), kerahasiaan (Confidentiality) dan ketersediaan (Availability). DiamantePro Digital Creative bertempat di Jakarta adalah perusahaan platform digital yang menyediakan jasa undangan atau Invitation seperti undangan pernikahan, meeting internal maupun seminar. Pada dasarnya undangan memerlukan adanya identitas pribadi dari individu yang akan diundang. Maka dari itu untuk melindungi data pengguna dari kebocoran data identitas, DiamantePro Digital Creative memerlukan adanya pengujian penetrasi melalui website mereka. Metode penetrasi tingkat keamanan website dapat menggunakan Information Systems Security Assessment Framework (ISSAF) dan Open Web Application Security Project (OWASP). Hasil pengujian membuktikan bahwa website diaundangkamu.com tidak dapat ditembus karena memiliki fitur security yang mumpuni seperti Naga Cyber Defense dari hostingan rumahweb.com.Kata kunci: Pengujian Penetrasi, ISSAF, OWASP
Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
Authors: Meringolo Maria , Montanari Martina , D'Antoni Simona , Martella Giuseppina , Atiallah Ilham El , Ponterio Giulia , Tassone Annalisa , Reverte Ingrid , Caprioli Daniele , Strimpakos Georgios , Pieroni Luisa , Catania Maria Vincenza , Bonsi Paola 
Published: January 2025

Abstract

Human genetics indicates enrichment of synaptic pathway-related mutations in Autism Spectrum Disorder (ASD). Accordingly, several preclinical studies have reported synaptic alterations in different brain areas of relevant ASD mouse models. In particular, we previously showed that corticostriatal long-term synaptic depression is impaired in the dorsal striatum of mice carrying the ASD-associated R451C mutation in the NL3 gene, coding for the postsynaptic protein neuroligin 3. Here, we used behavioral, proteomic, biochemical, and electrophysiological approaches to explore the dorsal striatum-dependent functions in the R451C-NL3 knock-in mouse model of ASD.
A detailed behavioral analysis confirmed striatum-dependent alterations in these mice. We further explored the synaptic function in the dorsal striatum, disclosing modifications of the glutamatergic postsynaptic density protein composition and the impairment of different forms of corticostriatal long-term synaptic plasticity involving the activation of group I metabotropic glutamate receptors, namely activity-dependent depression and potentiation, and pharmacological 3,5-DHPG-induced synaptic depression. Notably, activation of group I metabotropic glutamate receptors was not able to potentiate NMDA receptor-mediated currents. Protein expression levels of type 5 metabotropic glutamate receptor were reduced at striatal synapses, whereas the protein level and function of glutamate ionotropic receptors were unaltered. Overall, our findings point to a significant impairment of metabotropic glutamate receptor type 5 signaling in neuroligin 3 knock-in mice, affecting the dorsal striatum circuitry, that has been implicated in several autism-related behaviors.
Evaluation of the Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Patients With Anemia Associated With Chronic Kidney Disease Receiving Hemodialysis
Authors: Navarro-Gonzales Pamela , Chavan Ajit , Wang Don , Burke Steven , Dykstra Kevin 
Published: January 2025

Abstract

Background
Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor for treatment of anemia in dialysis-dependent chronic kidney disease (CKD) with a starting dose of 300 mg once daily (dose adjustments up to 600 mg). A recent phase 1b study evaluated the pharmacokinetics, pharmacodynamics, and safety of higher vadadustat doses (500–900 mg) in healthy volunteers. Here we report the pharmacokinetic (PK), pharmacodynamic (PD), and safety characterization of higher doses of vadadustat in patients with CKD receiving dialysis.
Methods
This phase 1b, randomized, open-label study evaluated the pharmacokinetics and pharmacodynamics of vadadustat (600, 750, or 900 mg) in patients with CKD-related anemia receiving hemodialysis over a 10-day treatment period. Eligible patients were randomized 2:2:2:1 to vadadustat 600, 750, 900 mg daily or an intravenous erythropoiesis-stimulating agent, respectively. For vadadustat groups, blood samples for PK and PD analyses were collected on Day 1 and Day 8. PK analyses included area under the plasma concentration time curve (AUC) from dosing to last quantifiable concentration and to infinity, and to maximum plasma concentration (Cmax). PD analyses measured serum erythropoietin (EPO), hemoglobin, and red blood cells (RBCs). Safety assessments included adverse events in the safety population (patients who received ≥1 dose of study drug).
Results
In the vadadustat groups, a dose-dependent increase in plasma exposure of vadadustat (Cmax and AUC), with modest accumulation, was observed on Day 1 and Day 8. Vadadustat increased plasma EPO concentrations, with a variable EPO response observed in each group. Relative to baseline, mean hemoglobin and RBC levels remained unchanged, with no significant changes observed in any treatment group. Vadadustat was well-tolerated.
Conclusions
The current study characterized the PK and PD response (EPO and reticulocytes) and safety profile of vadadustat at doses of 600, 750, and 900 mg in patients with CKD receiving dialysis. Overall, vadadustat was well tolerated. These findings will contribute to the development of higher-dose regimens for further investigation in phase 3 studies.
Trial Registration
ClinicalTrials.gov ID NCT03992066; https://clinicaltrials.gov/study/NCT03992066; Updated September 9, 2020. Accessed November 22, 2024.
GraphVelo allows for accurate inference of multimodal omics velocities and molecular mechanisms for single cells
Authors: Xing Jianhua , Chen Yuhao , Zhang Yan , Gan Jiaqi , Ni Ke , Chen Ming , Bahar Ivet 
Published: January 2025

Abstract

RNA velocities and generalizations emerge as powerful approaches for extracting time-resolved information from high-throughput snapshot single-cell data. Yet, several inherent limitations restrict applying the approaches to genes not suitable for RNA velocity inference due to complex transcriptional dynamics, low expression, or lacking splicing dynamics, or data of non-transcriptomic modality. Here, we present GraphVelo, a graph-based machine learning procedure that uses as input the RNA velocities inferred from existing methods and infers velocity vectors lying in the tangent space of the low-dimensional manifold formed by the single cell data. GraphVelo preserves vector magnitude and direction information during transformations across different data representations. Tests on multiple synthetic and experimental scRNA-seq data including viral-host interactome and multi-omics datasets demonstrate that GraphVelo, together with downstream generalized dynamo analyses, extends RNA velocities to multi-modal data and reveals quantitative nonlinear regulation relations between genes, virus and host cells, and different layers of gene regulation.