bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who is motivated to accept a booster and annual dose? A dimensional and person‐centered approach
Authors: Waterschoot Joachim , Van Oost Pascaline , Vansteenkiste Maarten , Brisbois Marie , Schmitz Mathias , Morbée Sofie , Klein Olivier , Luminet Olivier , Van den Bergh Omer , Raemdonck Eveline , Yzerbyt Vincent 
Published: February 2023

AbstractThe transmissibility of new COVID‐19 variants and decreasing efficacy of vaccines led authorities to recommend a booster and even an annual dose. However, people's willingness to accept new doses varied considerably. Using two independent longitudinal samples of 4596 (Mean age = 53.6) and 514 (Mean age = 55.9) vaccinated participants, we examined how people's (lack of) vaccination motivation for their first dose was associated with their intention to get a booster (Sample 1) and an annual dose (Sample 2) several months later (Aim 1). We also aimed to capture the impact of the motivational heterogeneity on these intentions by capitalizing on participants' different motivational profiles collected at baseline (Aim 2). Across both samples, autonomous motivation, controlled motivation, and distrust‐based amotivation were uniquely related to, respectively, higher, lower, and even lower booster and annual dose intentions. Further, a two‐step clustering procedure revealed five profiles, with the profiles characterized by higher autonomous motivation (i.e. Good Quality and High Quantity profiles) reporting the highest vaccination intentions and the profile characterized by the highest number of obstacles (i.e. Global Amotivated profile) yielding the lowest vaccination intentions. These results stress the critical need to support citizens' volitional endorsement of vaccination to harvest long‐term benefits with respect to COVID‐19.
Mortars in context: An integrated study of mortars and plasters from the so‐called Ginnasio in Solunto (Sicily, Italy)
Authors: Boese Beatrice , Amicone Silvia , Cantisani Emma , Schön Frerich , Berthold Christoph 
Published: February 2023

AbstractThis paper presents a multipronged scientific study of mortars and plasters of the so‐called Ginnasio in the Hellenistic–Roman city of Solunto (Sicily, Italy). A selection of 16 well‐contextualized samples was collected to represent different functions and building phases of this private house. The results show that a variety of locally available raw materials was used as aggregates and to produce binders. The diversity of raw materials’ sources and production techniques identified in this study reveals the advanced technological knowledge of the builders of Solunto, indicating a complex relationship between the settlement's cityscape and its surrounding landscape.
A three‐gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia
Authors: Wang Yu‐Hung , Yao Chi‐Yuan , Lin Chien‐Chin , Gurashi Kristian , Amaral Fabio M. R. , Bossenbroek Hasse , Jerez Andres , Somervaille Tim C. P. , Binder Moritz , Patnaik Mrinal M. , Hou Hsin‐An , Chou Wen‐Chien , Batta Kiran , Wiseman Daniel H. , Tien Hwei‐Fang 
Published: February 2023

SummaryLeukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17‐gene LSC score, LSC‐17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three‐gene expression signature (LSC‐3, derived from the LSC‐17 score) as an independent and robust prognostic factor for leukaemia‐free and overall survival in CMML. We propose that LSC‐3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.
Prognostic impact of variant histologies in urothelial bladder cancer treated with radical cystectomy
Authors: Claps Francesco , van de Kamp Maaike W. , Mayr Roman , Bostrom Peter J. , Shariat Shahrokh F. , Hippe Katrin , Bertz Simone , Neuzillet Yann , Sanders Joyce , Otto Wolfgang , van der Heijden Michiel S. , Jewett Michael A.S. , Stöhr Robert , Zlotta Alexandre R. , Trombetta Carlo , Eckstein Markus , Mertens Laura S. , Burger Maximilian , Soorojebally Yanish , Wullich Bernd , Bartoletti Riccardo , Radvanyi François , Pavan Nicola , Sirab Nanour , Mir M. Carmen , Pouessel Damien , van der Kwast Theo H. , Hartmann Arndt , Lotan Yair , Bussani Rossana , Allory Yves , van Rhijn Bas W.G. 
Published: February 2023

ObjectivesTo evaluate variant histologies (VHs) for disease‐specific survival (DSS) in patients with invasive urothelial bladder cancer (BCa) undergoing radical cystectomy (RC).Materials and MethodsWe analysed a multi‐institutional cohort of 1082 patients treated with upfront RC for cT1‐4aN0M0 urothelial BCa at eight centres. Univariable and multivariable Cox’ regression analyses were used to assess the effect of different VHs on DSS in overall cohort and three stage‐based analyses. The stages were defined as ‘organ‐confined’ (≤pT2N0), ‘locally advanced’ (pT3‐4N0) and ‘node‐positive’ (pTanyN1‐3).ResultsOverall, 784 patients (72.5%) had pure urothelial carcinoma (UC), while the remaining 298 (27.5%) harboured a VH. Squamous differentiation was the most common VH, observed in 166 patients (15.3%), followed by micropapillary (40 patients [3.7%]), sarcomatoid (29 patients [2.7%]), glandular (18 patients [1.7%]), lymphoepithelioma‐like (14 patients [1.3%]), small‐cell (13 patients [1.2%]), clear‐cell (eight patients [0.7%]), nested (seven patients [0.6%]) and plasmacytoid VH (three patients [0.3%]). The median follow‐up was 2.3 years. Overall, 534 (49.4%) disease‐related deaths occurred. In uni‐ and multivariable analyses, plasmacytoid and small‐cell VHs were associated with worse DSS in the overall cohort (both P = 0.04). In univariable analyses, sarcomatoid VH was significantly associated with worse DSS, while lymphoepithelioma‐like VH had favourable DSS compared to pure UC. Clear‐cell (P = 0.015) and small‐cell (P = 0.011) VH were associated with worse DSS in the organ‐confined and node‐positive cohorts, respectively.ConclusionsMore than 25% of patients harboured a VH at time of RC. Compared to pure UC, clear‐cell, plasmacytoid, small‐cell and sarcomatoid VHs were associated with worse DSS, while lymphoepithelioma‐like VH was characterized by a DSS benefit. Accurate pathological diagnosis of VHs may ensure tailored counselling to identify patients who require more intensive management.
EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma
Authors: Meng Kun , Hu Yuyu , Wang Dingkang , Li Yuying , Shi Fujin , Lu Jiangli , Wang Yang , Cao Yun , Zhang Chris Zhiyi , He Qing‐Yu 
Published: February 2023

AbstractThe biological function of many mitochondrial proteins in mechanistic detail has not been well investigated in clear cell renal cell carcinoma (ccRCC). A seven‐mitochondrial‐gene signature was generated by Lasso regression analysis to improve the prediction of prognosis of patients with ccRCC, using The Cancer Genome Atlas and Clinical Proteomic Tumor Analysis Consortium cohort. Among those seven genes, EFHD1 is less studied and its role in the progression of ccRCC remains unknown. The decreased expression of EFHD1 was validated in clinical samples and was correlated with unfavorable outcome. Overexpression of EFHD1 in ccRCC cells resulted in the reduction of mitochondrial Ca2+, and the inhibition of cell migration and invasion in vitro and tumor metastasis in vivo. Mechanistically, EFHD1 physically bound to the core mitochondrial calcium transporter (mitochondrial calcium uniporter, MCU) through its N‐terminal domain. The interaction between EFHD1 and MCU suppressed the uptake of Ca2+ into mitochondria, and deactivated the Hippo/YAP signaling pathway. Further data revealed that the ectopic expression of EFHD1 upregulated STARD13 to enhance the phosphorylation of YAP protein at Ser‐127. The knockdown of STARD13 or the overexpression of MCU partly abrogated the EFHD1‐mediated induction of phosphorylation of YAP at Ser‐127 and suppression of cell migration. Taken together, the newly identified EFHD1–MCU–STARD13 axis participates in the modulation of the Hippo/YAP pathway and serves as a novel regulator in the progression of ccRCC.
Challenges in operationalizing conceptual models in aetiological research
Authors: Celeste Roger Keller , Colvara Beatriz Carriconde , Rech Rafaela Soares , Reichenheim Michael Eduardo , Bastos João Luiz 
Published: February 2023

AbstractConceptual or theoretical models are crucial in developing causal hypotheses and interpreting study findings, but they have been underused and misused in aetiological research, particularly in dentistry and oral epidemiology. Good models should incorporate updated evidence and clarify knowledge gaps to derive logical hypotheses. Developing models and deriving testable hypotheses in operational models can be challenging, as seen in the four examples referred to in this commentary. One challenge concerns the theoretical validity of the model, while another relates to difficulties in operationalizing abstract concepts. A third challenge refers to the lack of sufficient information in the dataset to test partially or even the whole model. Finally, a common challenge is the application of a conceptual model to different contexts. Among the existing methodological approaches to operationalize conceptual models, causal graphs may be helpful, especially when combined with approaches from diverse disciplinary fields via triangulation.
The Necessity of qualitative research for advancing oral health
Authors: Macdonald Mary Ellen 
Published: February 2023

AbstractResearchers are engaged with producing knowledge. Through this knowledge production, they make claims about the world. For applied health researchers, our knowledge production is both a scientific as well as a moral activity. Increasingly, oral health researchers are turning to qualitative research, a research approach that takes science and morality seriously. Qualitative research pushes researchers to think about the different worlds in which people live and work, and endeavours to generate data that reflect those worlds. This paper argues that humans are complex, and that qualitative approaches are necessary for understanding how we are all deeply embedded in historical, social, cultural and political contexts, and why this matters when thinking about oral health. This paper also dispels myths about the limitations of qualitative research and proposes future directions to improve the sophistication of qualitative oral health sciences.
Causal inference in dentistry: Time to move forward
Authors: Schuch Helena Silveira , Nascimento Gustavo Giacomelli , Demarco Flávio Fernando , Haag Dandara Gabriela 
Published: February 2023

AbstractOral conditions represent a critical public health challenge, and together with descriptive and predictive epidemiology, causal inference has a crucial role in developing and testing preventive oral health interventions. By identifying not just correlations but actual causes of disease, causal inference may quantify the average effect of interventions and guide policies. Although authors are not usually explicit about it, most oral health studies are guided by causal questions. However, methodological deficiencies limit their interpretability and the implementation of their findings. This manuscript is a call to action on the use of causal inference in oral research. Its application starts with asking theoretically sound questions and being explicit about causal relationships, defining the estimates to evaluate, and measuring them properly. Beyond promoting causal analytical approaches, we emphasize the need for more causal thinking to promote thoughtful research questions and the use of appropriate methods to answer them. Causal inference relies on the plausibility of assumptions underlying the data analysis and the quality of the data, and we argue that high‐quality observational studies can be used to estimate average causal effects. Although individual efforts to embrace causal inference in dentistry are essential, they will not yield substantial results if not led by a systematic and structural change in the field. We urge scientific societies, funding bodies, dental schools, and journals to promote transparency in research, causal thinking, and causal inference projects to move the field toward more meaningful studies. It is also time for researchers to move forward and connect with the community, co‐produce investigations and translate their findings, and engage in interventions that impact public health. We conclude by highlighting the importance of triangulating results from different data sources and methods to support causal inference and inform decision‐making on interventions to effectively improve population oral health.
Conceptualizing inequities and oppression in oral health research
Authors: Fleming Eleanor , Bastos João L. , Jamieson Lisa , Celeste Roger K. , Raskin Sarah E. , Gomaa Noha , McGrath Colman , Tiwari Tamanna 
Published: February 2023

AbstractMajor sociohistorical processes have profound effects on oral health, with impacts experienced through structural oppression manifested in policies and practices across the lifespan. Structural oppression drives oral health inequities and impacts population‐level oral health. In this global perspective paper, we challenge old assumptions about oral health inequities, address misleading conceptualizations in their description and operation and reframe oral health through the lens of intersecting systems of oppression. Furthermore, we emphasize the need for oral health researchers to explore causal pathways through which oppression harms oral health and engage in social science concepts to understand the root causes of oral health inequities fully. Finally, we call on policymakers, dental scholars and decision makers to consider health equity in all policies and to take a systems‐oriented approach to effectively address oral health inequities.
Methods to madness: The utility of complex systems science in a mad, mad world
Authors: Heaton Brenda , Baker Sarah R. 
Published: February 2023

AbstractExisting methods in social [oral] epidemiology primarily utilize statistical models that assume static characteristics of individuals and environments. While useful, an over reliance on these methods in the social and behavioural sciences can unnecessarily limit perspective and progress as even the most advanced statistical methods cannot capture complex behaviour over time given that systems evolve, environments respond, and behaviours and beliefs crystalize or deteriorate based on a variety of social, environmental and access variables. The recent consensus statement on Future Directions for the Behavioral and Social Sciences in Oral Health acknowledges that dental, oral and craniofacial health emerge from the complex interplay of multiple factors at multiple levels over time and highlights the need for the incorporation of new and underutilized methodologies. Complex Systems Science offers a suite of tools and methodologies that are responsive to the generative mechanisms and processes that underlie population distributions of oral health and disease. Specifically, they assume intricate, dynamic interactions between individuals and groups, they facilitate the study and synthesis of interconnections between people (e.g. patients, healthcare providers and policy makers), how these change over time, any differences across settings, and provide an opportunity to guide future longitudinal data collection and intervention science more effectively. This paper aims to provide an introduction to foundational principles of complex systems, complex systems thinking, and methods found in complex systems science, including social network analysis, system dynamics models and agent‐based models, and offers perspectives on the challenges faced and opportunities afforded in the incorporation of these methods into the population oral health sciences.
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Authors: Kotsakis Georgios A. , Nguyen Thomas T. , Siormpas Konstantinos , Pikos Michael A. , Pohl Snjezana , Tarnow Dennis , Mitsias Miltiadis ,   Root Membrane Group
Published: February 2023

The cover image is based on the Original Article Clinical outcomes of retention of the buccal root section combined with immediate implant placement: A systematic review of longitudinal studies by Georgios A. Kotsakis DMD, MS et al., https://doi.org/10.1111/cid.13150.
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Association between psychomotor function and ALDH2 genotype after consuming barley shochu: A randomized crossover trial
Authors: Matsuura Keiko , Kushio Satoshi , Imai Hiromitsu , Kudo Hideo , Wakuda Hirokazu , Otani Naoyuki , Kuranari Masae , Sekiguchi Ai , Ohyama Tetsuji , Uemura Naoto 
Published: February 2023

AbstractSustained exposure to acetaldehyde, the major metabolite of ethanol, may influence psychomotor performance even after the breath ethanol level significantly drops several hours following ethanol consumption. We examined the relationship between psychomotor function and changes in exhaled ethanol and acetaldehyde concentrations after consuming a low dose (0.33 g/kg) of barley shochu, a traditional Japanese distilled alcohol beverage, at the point when the exhaled ethanol concentrations dropped below 78,000 parts per billion (0.15 mg/L), the standard threshold for driving under the influence of alcohol in Japan. We assessed how the genetic polymorphisms of rs671 G/G homozygous (*1/*1) and G/A heterozygous (*1/*2) of ALDH2 influenced the kinetics of ethanol and acetaldehyde in exhaled air and psychomotor dynamics using the Digit Symbol Substitution Test (DSST), Critical Flicker Fusion Test (CFFT), and visual analogue scale (VAS) up to 12 h after shochu or water intake. There was no significant difference in DSST and CFFT scores depending on genotype; however, the time required for the DSST to attain the level prior to drinking was longer in the ALDH2 *1/*2 group than in the *1/*1 group. In the VAS test, facial flushing and mood elevation tended to be higher in the *1/*2 group after shochu consumption. VAS scores for mood elevation and facial flushing correlated with acetaldehyde concentration in exhaled breath. These results indicate that DSST recovery tends to be slower and mood elevation higher in the ALDH2 *1/*2 group even when exposed to a low dose of alcohol.
Clinicohistopathologic challenges and traps in the diagnosis of nail unit melanoma
Authors: Jiang Angela J. , Abbott James J. , Higgins H. William , Elenitsas Rosalie , Rubin Adam I. 
Published: February 2023

AbstractMelanoma of the nail apparatus is challenging to diagnose for both dermatologists and dermatopathologists. Misdiagnosis or delayed diagnosis of nail unit melanoma can have fatal consequences and legal ramifications. This review educates dermatopathologists on challenges and traps they should be aware of to avoid misdiagnosis of nail unit melanoma. We present illustrative difficult cases that introduce several themes regarding challenges in the diagnosis of nail unit melanoma: specimens with subtle histopathologic findings, challenges in immunoperoxidase interpretation, and how clinical knowledge and surgical procedural knowledge are mandatory to make the diagnosis. Dermatopathologists will be aware of when and how to suspect nail unit melanoma in unusual circumstances.
Benefits and challenges in implementation of artificial intelligence in colonoscopy: World Endoscopy Organization position statement
Authors: Mori Yuichi , East James E. , Hassan Cesare , Halvorsen Natalie , Berzin Tyler M. , Byrne Michael , von Renteln Daniel , Hewett David G. , Repici Alessandro , Ramchandani Mohan , Al Khatry Maryam , Kudo Shin‐ei , Wang Pu , Yu Honggang , Saito Yutaka , Misawa Masashi , Parasa Sravanthi , Matsubayashi Carolina Ogawa , Ogata Haruhiko , Tajiri Hisao , Pausawasdi Nonthalee , Dekker Evelien , Ahmad Omer F. , Sharma Prateek , Rex Douglas K. 
Published: February 2023

The number of artificial intelligence (AI) tools for colonoscopy on the market is increasing with supporting clinical evidence. Nevertheless, their implementation is not going smoothly for a variety of reasons, including lack of data on clinical benefits and cost‐effectiveness, lack of trustworthy guidelines, uncertain indications, and cost for implementation. To address this issue and better guide practitioners, the World Endoscopy Organization (WEO) has provided its perspective about the status of AI in colonoscopy as the position statement. WEO Position Statement: Statement 1.1: Computer‐aided detection (CADe) for colorectal polyps is likely to improve colonoscopy effectiveness by reducing adenoma miss rates and thus increase adenoma detection; Statement 1.2: In the short term, use of CADe is likely to increase health‐care costs by detecting more adenomas; Statement 1.3: In the long term, the increased cost by CADe could be balanced by savings in costs related to cancer treatment (surgery, chemotherapy, palliative care) due to CADe‐related cancer prevention; Statement 1.4: Health‐care delivery systems and authorities should evaluate the cost‐effectiveness of CADe to support its use in clinical practice; Statement 2.1: Computer‐aided diagnosis (CADx) for diminutive polyps (≤5 mm), when it has sufficient accuracy, is expected to reduce health‐care costs by reducing polypectomies, pathological examinations, or both; Statement 2.2: Health‐care delivery systems and authorities should evaluate the cost‐effectiveness of CADx to support its use in clinical practice; Statement 3: We recommend that a broad range of high‐quality cost‐effectiveness research should be undertaken to understand whether AI implementation benefits populations and societies in different health‐care systems.
Factors associated with outcomes of severe acute necrotizing encephalopathy: A multicentre experience in Malaysia
Authors: Lee Vanessa Wan Mun , Khoo Teik Beng , Teh Chee Ming , Heng Hock Sin , Li Limin , Yusof Yusma Lyana Md , Yahaya Nor Azni , Dharshini Sangita , Wong Sau Wei , Nickson Tai ,   ANE Malaysia Outcome Study Group
Published: February 2023

AbstractThis case series compared clinical variables and various combinations of immunotherapy received with outcomes of patients with severe acute necrotizing encephalopathy (ANE). We performed a retrospective review of clinical variables, immunotherapy received, and outcomes (based on the modified Rankin Scale) in Malaysia between February 2019 and January 2020. Twenty‐seven children (12 male), aged 7 months to 14 years (mean 4 years) at diagnosis were included. Of these, 23 had an ANE severity score of 5 to 9 out of 9 (high risk). Eleven patients received tocilizumab (four in combination with methylprednisolone [MTP], seven with MTP + intravenous immunoglobulin [IVIG]) and 16 did not (two received MTP alone, 14 received MTP + IVIG). Nine died. Among the survivors, six had good outcomes (modified Rankin Score 0–2) at 6 months follow‐up. All patients who received tocilizumab in combination with MTP + IVIG survived. Twenty children received first immunotherapy within 48 hours of admission. No significant association was found between the timing of first immunotherapy with outcomes. Those with brainstem dysfunction (p = 0.016) were observed to have poorer outcomes. This study showed a trend towards better survival when those with severe ANE were treated with tocilizumab in combination with MTP + IVIG. However, larger studies will be needed to determine the effect of this regime on the long‐term outcomes.