bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency Left Colectomy for Colon Cancer is Not Associated with Worst Oncologic Resection Quality Compared to Elective Surgery
Authors: Hazan Danny , Ishakov Arkadi , Levi Sammy , Shimonov Mordechai , Dayan Katia 
Published: February 2023

Abstract
Purpose:
Emergency colectomy of the left colon and sigma carries a higher risk of complication than elective colectomy. The aim of our study was to evaluate our results and to compare the outcome of these two operations.
Methods
Each patient included in this retrospective analysis underwent laparoscopic or open colectomy for malignant neoplasms with curative intent between 2011 and 2019. Surgical techniques were defined as emergency or elective depending on the timing of the operation, regardless of operational technique.
Results
A total of 242 patients were recruited, of which 125 had had emergency colectomies. Comparatively, 117 such patients underwent elective colectomies. There were no differences between the groups in factors such as age, gender, demographics and co-morbidities. The main reason for emergency operation included perforation in 105 patients (84%), and obstruction in 20 patients (16%).
No difference in the number of lymph nodes harvested (LNH) were found between the 2 groups (mean of 17 LNH, SD +-8). The length of stay (LOH) and time to first flatulence was different between the groups (8.72 +-4.17 days for the elective surgery vs. 19.28+-23.5 days for the emergency surgery for LOH, and 3+-1 days for the elective group Vs. 9+-11.5 days for the emergency group for time to first flatulence, p<0.001 in both).
The emergency group exhibited more serious complications (G III IV) than the elective group in the Clavien-Dindo classification. No difference was noted with regards to 30 days' survivals, length of operation and blood loss.
Conclusion
Our study suggests that the outcome of emergency colectomy of the left colon demonstrated excellent oncologic results compared to that of the elective group. However, emergency operation carries some degree of higher complication rate that need to be taken into account. Best results will be achieved by tailoring each patient’s status with the utilization of the best operation and operative team experience.
Enhancing Multisensory Experiences Through Temperature-Controlled Wind Effects
Authors: Saleme Estevao Bissoli , Silveira Aleph Campos da , Covaci Alexandra , Rodrigues Eduardo , Santos Celso Alberto Saibel , Ghinea Gheorghita 
Published: February 2023

Abstract
In this paper, we introduce Twirl, a haptic system that allows the creation and delivery of hot and cold airflow synchronised with audiovisual content. Twirl combines vaporization of cooled water by Peltier elements for cold wind and hair dryers for warm wind steered by wind fans. To assess our system, we conducted several studies. First, we analyzed the time our devices take to deliver these effects considering different starting temperatures in the environment. Then, we annotated three videos with hot wind, cold wind, and both effects respectively to observe the feasibility of having those effects integrated with audiovisual content. Next, we assessed the temperature variation of the devices as a function of distance. Finally, we distributed questionnaires such as Virtual Reality Hardware Acceptance Model and Lombard's Temple Presence Inventory questionnaires to assess different user experience facets and attitudes towards the proposed device. Preliminary results highlighted positive user attitudes and experiences towards Twirl.
Downregulated DUXAP8 lncRNA impedes trophoblast cell proliferation and migration by epigenetically upregulating TFPI2 expression
Authors: Tang Xiaotong , Cao Yueying , Wu Dan , Xu Yetao , Sun Lizhou 
Published: February 2023

Abstract
Backgorund
Preeclampsia (PE), a pregnancy complication characterized by new-onset hypertension and proteinuria during the second trimester, is the leading cause of neonatal and maternal morbidity and mortality. In the etiology of PE, failure of uterine spiral artery remodeling may be related to functioning abnormally of trophoblast cells, leading to the occurrence and progression of PE. Recently, long noncoding RNAs (lncRNAs) have been reported to play critical roles in PE nowadays. This study aimed to investigate the expression and functions of the TFPI2 pathway-related lncRNA DUXAP8.
Methods
DUXAP8 expression in the placenta from pregnancies was examined using qPCR. Then, the in vitro functions of DUXAP8 were investigated through MTT, EdU, colony, transwell, and flow cytometry experiments. The downstream gene expression profiles were assessed using RNA transcriptome sequencing analysis and verified using qPCR and western blot. Furthermore, Immunoprecipitation (RIP), chromatin immunoprecipitation (CHIP) and fluorescence in situ hybridization (FISH) were used to detect the interaction between lncDUXAP8/EZH2/TFPI2.
Results
The expression of lncRNA DUXAP8 in placenta of patients with eclampsia was significantly decreased. After knockout of DUXAP8, the proliferation and migration of trophoblasts were significantly decreased, and the percentage of apoptosis was increased. Flow cytometry showed that low expression of DUXAP8 increased the accumulation of cells in G2/M phase, while overexpression of DUXAP8 had the opposite effect. We also proved that DUXAP8 epigenetically inhibited TFPI2 expression by recruiting EZH2 and mediating H3K27me3 modification.
Conclusion
Together, these resulting data clarify that aberrant expression of DUXAP8 is involved in the potential PE development and progress. Unraveling the role of DUXAP8 will provide novel insights into the pathogenesis of PE.
Differential responsesof pulmonary vascular cells from PAH patients and controls to TNFα and the effect of the BET inhibitor JQ1
Authors: Mumby S , Perros F , Grynblat J , Manaud G , Papi A , Casolari P , caramori G , Humbert M , Wort S J , Adcock I M 
Published: February 2023

Abstract
Background
Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal (BET) proteins are required for the expression of a subset of NF-κB-induced inflammatory genes which can be inhibited by the BET mimic JQ1+. We hypothesised that JQ1 + would supress TNFα-driven inflammatory responses in human pulmonary vascular cells from PAH patients.
Methods
Immunohistochemical staining of human peripheral lung tissue (N = 14 PAH and N = 12 non-PAH) was performed for the BET proteins BRD2 and 4. Human pulmonary microvascular endothelial cells (HPMEC) and pulmonary artery smooth muscle cells (HPASMC) from PAH patients (N = 4) and non-PAH controls (N = 4) were stimulated with TNFα in presence or absence of JQ1 + or its inactive isomer JQ1-. IL-6 and − 8 mRNA was measured by RT-qPCR and protein levels by ELISA. Chromatin immunoprecipitation analysis was performed using EZ-ChIP™ and NF-κB p65 activation determined using a TransAm kit. MTT assay was used to measure cell viability.
Results
Nuclear staining of BRD2 and BRD4 was significantly (p < 0.0001) increased in the lung vascular endothelial and smooth muscle cells from PAH patients compared to controls with normal lung function. TNFα-driven IL-6 release from both HPMECs and HPASMCs was greater in PAH cells than control cells. Levels of CXCL8/IL-8 protein release was higher in control HPASMCs than in PAH cells with similar release observed in HPMECs. TNFα-induced recruitment of activated NF-κB p65 to the IL-6 and CXCL8/IL-8 promoters were similar in both cell types and between subject groups. JQ1 + suppressed TNFα-induced IL-6 and CXCL8/IL-8 release and mRNA expression to a comparable extent in control and PAH HPMECs and HPASMCs. JQ1 had a greater efficacy on IL-6 release in HPMEC and on CXCL8/IL-8 release in HPASMC.
Conclusion
BET inhibition decreases TNFα driven inflammation in primary pulmonary vascular cells. JQ1 anti-inflammatory actions suggests distinct cell-specific regulatory control of these genes. BET proteins could be a target for future therapies for PAH.
Agreement of wall shear stress distribution between two core laboratories using three-dimensional quantitative coronary angiography
Authors: Kageyama Shigetaka , Tufaro Vincenzo , Torii Ryo , Karamasis Grigoris , Rakhit Roby , Poon Eric , Aben Jean-Paul , Baumbach Andreas , Serruys Patrick , Onuma Yoshinobu , Bourantas Christos 
Published: February 2023

Abstract
Purpose: Wall shear stress (WSS) estimated in models reconstructed from intravascular imaging and 3-dimensional-quantitative coronary angiography (3D-QCA) data provides important prognostic information and enables identification of high-risk lesions. However, these analyses are time-consuming and require expertise, limiting WSS adoption in clinical practice. Recently, a novel software has been developed for real-time computation of time-averaged WSS (TAWSS) and multidirectional WSS distribution. This study aims to examine its inter-corelab reproducibility.
Methods: Sixty lesions (20 coronary bifurcations) with a borderline negative fractional flow reserve were processed using the CAAS Workstation WSS prototype to estimate WSS and multi-directional WSS values. Analysis was performed by two corelabs and their estimations for the WSS in 3mm segments across each reconstructed vessel were extracted and compared.
Results: In total 700 segments (256 located in bifurcated vessels) were included in the analysis. A high intra-class correlation was noted for all the 3D-QCA and TAWSS metrics between the estimations of the two corelabs irrespective of the presence (range: 0.90-0.92) or absence (range: 0.89-0.90) of a coronary bifurcation, while the ICC was good-moderate for the multidirectional WSS (range: 0.72-0.86). Lesion level analysis demonstrated a high agreement of the two corelabls for detecting lesions exposed to an unfavourable haemodynamic environment (WSS >8.24Pa, κ=0.77) that had a high-risk morphology (area stenosis >61.3%, κ=0.71) and were prone to progress and cause events.
Conclusion: The CAAS Workstation WSS enables reproducible 3D-QCA reconstruction and computation of WSS metrics. Further research is needed to explore its value in detecting high-risk lesions.
Cross-sectional evaluation of outcome comparison methodology in dermatologic clinical trials and a simulation-based discussion of why outcome comparison technique matters
Authors: Hopkins Zachary H. , Swink J. Michael , Kaprive Jessica Forbes , Carlisle Ryan , Olayinka Jadesola , Moreno Christopher , Frost Zachary , Secrest Aaron M. 
Published: February 2023

Abstract
Clinical trial outcome comparison methodology can affect trial efficiency and interpretation. Our goal was to describe current trends in clinical trial outcome comparison methods among high-impact dermatology trials and perform simulations comparing direct comparison (DC), change-score based (CS), and baseline-adjusted analyses (BAA) to demonstrate the more subtle differences in these methods. We performed a cross-sectional examination of top-cited dermatology clinical trials over five years. Trials were retrieved from journal websites and extracted from PubMed. All clinical trials published in The Journal of the American Academy of Dermatology (JAAD), JAMA Dermatology, Journal of Investigative Dermatology (JID), The British Journal of Dermatology (BJD), and The Journal of the European Academy of Dermatology and Venereology (JEADV) from 2015–2019. Clinical trial analysis type including DC, CS, BAA, percent change from baseline (PoB), and responder analysis (RA). We evaluated the proportion of trials reporting each endpoint were reported and simulations assessing impact of analysis type on outcomes. Among 252 eligible trials, outcome comparison techniques included DC (75/252), CS (40/252), PoB (36/252), RA (98/252), and BAA (3/252). Among trials using CS, PoB, or RA, 25/174 adjusted for baseline score. No trials discussed relationship between baseline and final values; 85/252 selected patients based on baseline score; 8/85 gathered a post-randomization baseline score; 20/85 used a pre-randomization run-in period. Simulations demonstrated that BAA maximized trial efficiency for continuous outcomes. CS, PoB, and RA were common; however, when trials have continuous or ordinal outcomes, BAA is most efficient. PoB and RA are particularly inefficient. RA can promote misleading inference. Use of BAA optimizes inference, trial efficiency, and resource utilization.
On a Possible Mechanism for the Start or Resumption of Activity of Radio Galaxies in Clusters of Galaxies
Authors: Andreasyan Ruben , Abrahamyan Hayk , Paronyan Gurgen , Mikayelyan Gor , Mickaelian Areg 
Published: February 2023

Abstract
We study the close proximity of the well-known and well-studied 3C31 class FRI radio galaxy in order to reveal the influence of the environment on an extragalactic radio source. It was shown that about 110 million years ago the galaxies NGC 380 and NGC 386 were located near the galaxy NGC 383 (the parent galaxy of 3C31). On the other hand, the modeling of the spectral characteristics of the radio emission of the central part of the radio galaxy 3C31 gives an estimate of the age of the central jet of about 100 million years. Therefore, it can be assumed that one of the possible reasons for the appearance or resumption of the radioactivity of the galaxy NGC 383 may be a triple close passage of galaxies.
Environmental impact of sabotage of the Nord Stream pipelines
Authors: Sanderson Hans , Czub Michał , Koschinski Sven , Tougaard Jakob , Sveegaard Signe , Jakacki Jaromir , Fauser Patrik , Frey Torsten , Bełdowski Jacek , Beck Aaron , Przyborska Anna , Szturomski Bogdan , Kiciński Radosław 
Published: February 2023

Abstract
Armed conflicts have, in addition to severe impacts on human lives and infrastructure, also impacts on the environment, which needs to be assessed and documented. On September the 26th 2022, unknown perpetrators deliberately ruptured the two gas pipelines Nord Stream 1 and 2 with four coordinated explosions near a major chemical munition dump site near the Danish island of Bornholm in the Baltic Sea. While the massive release of natural gas into atmosphere raised serious concerns for climate, this paper assesses the overlooked direct impact of this sabotage on marine ecosystem. Seals and porpoises within a radius of four km would be at high risk of being killed by the shockwave, while temporary impact on hearing would be expected up to 50 km away. As the Baltic Proper population of harbour porpoises (Phocoena phocoena) is critically endangered, the loss or serious injury of even a single individual is considered a significant impact on the population. The rupture resulted in the resuspension of 250.000 metric tons of heavily contaminated sediment from deep-sea sedimentary basin for over a week, resulting in unacceptable risks towards fish and other biota in 11 km3 water for more than a month.
Quantum anisotropic antiferromagnetic Heisenberg model for description of magnetic properties at low temperatures from KTb(WO4)2
Authors: Freitas A. S. , Silva C. A. , cd L. S. Silva 
Published: February 2023

Abstract
Low dimensional magnetic systems have attracted the attention of several researchers in recentdecades, mainly because from exotic magnetic properties and the superconductivity that, in someof these systems, occur as result from characteristics of such materials. One of these materialsis KTb(WO4)2, generally considered a prototype from 2D Ising model, but which presents somepeculiarities on the magnetization diagram at low temperatures, especially the non-linear dependenceof magnetization with the applied magnetic field, behavior that cannot be described via puretwo-dimensional Ising model. The system presents structural and metamagnetic phase transition atlow temperatures, and we believe that such behavior may be related quantum effects and despitepresenting high anisotropy, this material it would not be a perfect prototype of the Ising model intwo dimensions. In this work, we present a proposal for using the anisotropic quantum Heisenbergmodel for describing the magnetic properties of the KTb(WO4)2 quasi-doublet with the objective,mainly, to describe non-linear properties at low temperatures. To achieve our goal, we simulatedthe magnetic properties of the material considering several anisotropy values via Quantum MonteCarlo (QMC) and compared the results with experimental data available already published. Tocomparison, we obtained diagrams of magnetization versus field and susceptibility dependence oftemperature (low temperature regime). Our results show excellent agreement with the experimentaldata, especially at low temperatures and for intermediate values from magnetic anisotropy.
ExomiRHub: a comprehensive database platform to integrate and analyze human extracellular miRNA transcriptome for discovering non-invasive biomarkers
Authors: Liu Yang , Min Zhuochao , Mo Jing , Ju Zhen , Chen Jianliang , Li Hanguang , Liang Weiling , Chan Godfrey Chi-Fung , Wei Yanjie , Zhang Wenliang 
Published: February 2023

Abstract
Background
Although studies reported that extracellular miRNAs have significant functions in regulating the development of human diseases, our understanding of their role in human diseases remains to be further addressed. Many extracellular miRNA expression data were deposited in public resources, which are heterogeneous and difficult to investigate due to the data generated from different high throughput platforms. To use these invaluable data for accelerating the discovery of non-invasive miRNA biomarkers, a comprehensive and user-friendly database platform is essential, especially for bench researchers who lack bioinformatics skills.
Methods
We integrated, standardized, and annotated human extracellular miRNA expression data and cancer-related miRNA transcriptome data from NCBI GEO and The Cancer Genome Atlas (TCGA), respectively. Moreover, we developed the ExomiRHub database platform that designed with comprehensive online analysis functions and tools to analyze these data or User's own data. These analysis functions and tools were designed to enable users to select samples, define groups and parameters for their own analysis.
Results
ExomiRHub includes 191 human extracellular miRNA expression datasets associated with 112 disease phenotypes, 62 treatments, and 24 genotypes, including 29,198 samples and 23 sample types. ExomiRHub further includes 16,012 miRNA transcriptome data of 156 cancer sub-types to enhance the usability of it in cancer research. To accelerate the identification of non-invasive miRNA biomarkers, ExomiRHub provides 25 online analytical and visualization functions to individually analyze these data. Moreover, ExomiRHub provides Web Service to enable users in conducting the analyses on their uploaded data. Furthermore, ExomiRHub provides four additional tools to evaluate the functions and targets of miRNAs and their variations. Finally, we used ExomiRHub and discovered non-invasive miRNA biomarkers associated with angiogenesis-related pathways for monitoring glioma progression.
Conclusion
The comprehensive data and functions of ExomiRHub can greatly accelerate the discovery of non-invasive miRNA biomarkers. It is freely accessible at the websites of http://hpcc.siat.ac.cn/exomirhub/ & http://www.biomedical-web.com/exomirhub/.
Evaluation of the Potential of Trade Gains for Nigeria in the African Continental Free Trade Agreement (AfCFTA)
Authors: Jato Terungwa Paul Joseph , Nwankwo Nneka , Awuzie Esther Ijeoma 
Published: February 2023

Abstract
Challenged by slow growth and development, there has been increased need and search for avenues that will bring accelerated development to the African continent. Such attempts include the African Continental Free Trade Agreement (AfCFTA) entered into by some African countries including Nigeria. The AfCFTA promises benefits for reginal development through individual benefits to member countries from trade. The study, thus, evaluated Nigeria’s potential of trade gains from the AfCFTA. The gravity model of trade was applied to analyze data about the variable obtained for Nigeria and some African states. The major findings of the study show that, the volume of Nigeria’s GPD, the distance between Nigeria and the trading partners, the Nigeria’s population, the per capital income in the region, the degree of trade openness, and sharing a colonial link with a country are capable of increasing trade flows to Nigeria, thus increasing her chances of gaining from the AfCFTA. Other variables like, the GDP of the trading partners, their population, and being a member of AfCFTA have the potential of lowing trade flow to Nigeria, all things being equal. It was concluded that Nigeria stands to benefit from her trade with these countries in the African continental free trade arena, all things being equal. Foreign trade policy actions should therefore be geared toward increased trade between these member states.
JEL Classification Code: C51, F17, F43, F53
Evaluation of three viral concentration methods for detection and quantification of SARS-CoV-2 in wastewater
Authors: Othman Ines , Helmi Amna , Slama Ichrak , Hamdi Rawand , Mastouri Maha , Aouni Mahjoub 
Published: February 2023

Abstract
Wastewater-based epidemiology (WBE) could be useful as an early warning system for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic spread. Viruses are highly diluted in wastewater. Therefore, a virus concentration step is needed for SARS-CoV-2 wastewater detection. We tested the efficiency of three wastewater viral concentration methods: ultrafiltration (UF), electronegative membrane filtration and aluminum hydroxide adsorption–elution. We spiked wastewater with inactivated SARS-CoV-2 and we collected 20 other wastewater samples from five sites in Tunisia. Samples were concentrated by the three methods and SARS-CoV-2 was quantified by reverse transcription digital PCR (RT-dPCR). The most efficient method was UF with a mean SARS-CoV-2 recovery of 54.03 ± 8.25. Moreover, this method provided significantly greater mean concentration and virus detection ability (95%) than the two other methods. The second-most efficient method used electronegative membrane filtration with a mean SARS-CoV-2 recovery of 25.59 ± 5.04% and the least efficient method was aluminum hydroxide adsorption–elution. This study suggests that the UF method provides rapid and straightforward recovery of SARS-CoV-2 in wastewater.
Evaluation of aquatic phytoremediation technologies in urban black–odorous water remediation technology using a multi-level fuzzy analysis method
Authors: Zhang Yue , Huang Peng , Fan Bo , Zhao Qing , Tian Tengfei , Zhang Weijia 
Published: February 2023

Abstract
The comprehensive analysis and research on the selection and evaluation of technology for urban black and odorous water remediation have not yet formed a complete system, and the technical analysis and comparison of the remediation technology are not combined with the characteristics of the river and the pollution status, which often could not achieve the expected effect. Combining the multi-level index division and fuzzy weight matrix calculation method, this paper establishes a comprehensive evaluation method for urban black–odorous water treatment technology based on multi-level fuzzy analysis. The proposed method was applied to assess four kinds of in situ purification-aquatic plant remediation technologies. The results showed that the pollutants removal efficiency of a submerged plant was much higher than that of an emergent aquatic plant, floating-leaved water plant and floating plant. Meanwhile, according to the evaluation model, the comprehensive grading order of in situ purification-aquatic plants was as follows: emergent aquatic plant (84.2044) &gt; submerged plant (78.838) &gt; floating-leaved water plant (72.7596) &gt; floating plant (66.4312). The calculations indicated that the ecological restoration project of black and odorous water should build an ecological restoration technology system based on in situ purification-submerged plant remediation technology, supplemented by other three types of aquatic phytoremediation technologies.