bluuebunny/crossref_metadata_2025_split huggingface dataset:
CSF lymphocytic pleocytosis does not predict a less favourable long-term prognosis in MS
Authors: Astbury Lauren , Kalra Seema , Tanasescu Radu , Constantinescu Cris S. 
Published: December 2022

Abstract
Objective
The role of CSF lymphocytic pleocytosis in predicting the clinical outcome of multiple sclerosis is unclear. We explored the impact of CSF pleocytosis at diagnosis on long-term disease progression in a large UK cohort.

Methods
We extracted demographic, clinical and CSF data of people with MS attending the MS clinics between 1996 and 2014 at two MS centres from the English Midlands. We compared EDSS at onset, follow up EDSS and progression indices Multiple Sclerosis Severity Score (MSSS), annualized change in EDSS and transition to secondary progression in the presence/absence of pleocytosis. Two-tailed student t-test, Mann–Whitney U test, Chi-Square or Fisher’s exact tests were used for detecting the differences.

Results
A total of 247 patients with MS (178 females; mean age 42.4; 217 with relapsing onset) were followed up for an average of 13.56 years (median 12 years). Almost 18% had lymphocytic CSF ≥ 5 per microliter. CSF pleocytosis was not associated with higher EDSS at the time of LP or at follow up, and other progression indices like MSSS, annualized change in EDSS or transition to secondary progression.

Discussion
CSF pleocytosis at MS diagnosis does not predict higher long-term disability and has no long-term prognostic value in routine clinical circumstances. Differences between MS populations and potential differences in disease activity at the time of CSF analysis may account for differences between studies.
Neuropsychological outcome in survivors of congenital diaphragmatic hernia at 5 years of age, what does it tell?
Authors: de Munck Sophie , Otter Suzan C. M. Cochius-den , Schnater J. Marco , van Rosmalen Joost , Peters Nina C. J. , van Gils-Frijters Annabel P. J. M. , van Haren Neeltje E. M. , Gischler Saskia J. , IJsselstijn Hanneke , Rietman André B. 
Published: December 2022

AbstractPrevious studies have frequently reported neurocognitive deficits in children born with congenital diaphragmatic hernia (CDH) at school age, which may contribute to academic difficulties. Yet, age at onset of these deficits is currently unknown. We evaluated neurocognitive skills with possible determinants in preschool children born with CDH. Eligible 5-year-old children born with CDH (2010–2015) who participated in our prospective structural follow-up program were included. We used the WPPSI-III to assess intelligence, subtests of the Kaufman-ABC for memory, and NEPSY-II to assess inhibition and attention. We included 63 children. Their test scores generally were within or significantly above normal range: total IQ = 103.4 (15.7) (p = 0.13); Verbal memory = 10.2 (2.8) (p = 0.61); Visuospatial memory = 11.4 (2.6) (p < 0.01); Inhibition = 10.5 (2.2), (p = 0.10). In univariable analyses, length of ICU-stay was negatively associated with IQ, and maximum vasoactive inotropic score and open repair were negatively associated with inhibition skills. In multivariable regression analysis, the latter association remained (B = 5.52, p = 0.04 (CI 0.32–10.72)). Conclusions: In these tested 5-year-old children born with CDH, neuropsychological outcome was normal on average. While problems in 8-year-olds are common, we did not detect onset of these problems at age 5. Yet, we cannot rule out that this cohort had a relatively mild level of disease severity; therefore, conclusions should be interpreted with caution. However, given the growing-into-deficit hypothesis, meaning that deviant brain development in early life is revealed once higher cognitive brain functions are demanded, follow-up should be conducted up to school age, and preferably beyond.

What is Known:• Children born with CDH are at risk for academic difficulties at school age.• Whether these difficulties can be detected already before school age is unknown.

What is New:• At age 5 years, intelligence, inhibition, attention, and memory skills were all within normal range, or even above, in children with CDH. This is supportive of the growing-into-deficit hypothesis in this patient population.• Those who underwent open surgical correction had poorer inhibition skills than those who were corrected with minimal access surgery.
The usefulness of a three-protein signature blood assay (Mastocheck®) for follow-up after breast cancer surgery
Authors: Kim Yumi , Kim Hong-Kyu , Lim Changjin , Kim Sungsoo , Ahn Kyung-Guen , Noh Dong-Young 
Published: December 2022

Abstract
Purpose
Mastocheck®, a proteomic-based blood assay, has been developed for early diagnosis of breast cancer. The purpose of this study is whether Mastocheck® is useful as a postoperative follow-up.

Methods
A total of 255 patients were analyzed. The patients were classified into longitudinal monitoring and recurrence/nonrecurrence cohorts. The longitudinal monitoring cohort consisted of 111 patients. In this cohort, blood analyses were performed three times (before surgery, 8 weeks after surgery, and between 6 months and one year after surgery), and a comparative analysis of the values of Mastocheck® and individual proteins at each time point was performed. The recurrence/nonrecurrence cohort consisted of 144 patients who had been followed up for more than 1 year, and the blood marker values at the time of local recurrence were compared to those of nonrecurrence patients.

Results
In the longitudinal monitoring cohort analysis, in 81 of 111 patients were diagnosed with breast cancer with Mastocheck® and the sensitivity was 73.0%. Of 111 patients in the longitudinal monitoring cohort, 108 had two blood analyses (before and 8 weeks after surgery), and three serial blood analyses were performed on 53 patients. The Mastocheck® value that were in the cancer range of 73.0% (in 81 of 111 patients) of patients before surgery, was within the normal range of 68.5% (in 74 of 108 patients) at 8 weeks after surgery and 88.7% (in 47 of 53 patients) from 6 months to 1 year after surgery. The value of Mastocheck® was significantly decreased after surgery compared to before surgery (p < 0.001). In the recurrence/nonrecurrence cohort analysis, the Mastocheck® values were in the cancer range in 38 out of 63 recurrence patients and within the normal range in 66 of 81 nonrecurrence patients (sensitivity of 60.3% and specificity of 80.2%).

Conclusions
Mastocheck® is expected to be used as a blood marker tool to aid in the early detection of recurrence during follow-up after breast cancer surgery.
Real-time probabilistic assessment of volcanic hazard for tephra dispersal and fallout at Mt. Etna: the 2021 lava fountain episodes
Authors: Pardini Federica , de’ Michieli Vitturi Mattia , Andronico Daniele , Esposti Ongaro Tomaso , Cristaldi Antonino , Neri Augusto 
Published: December 2022

AbstractStarting from February 2021, Mt. Etna (Italy) experienced a period of intense explosive activity with 17 lava fountain episodes between 16 February and 1 April 2021. During the eruptive cycle, the Istituto Nazionale di Geofisica e Vulcanologia-Osservatorio Etneo (INGV-OE) issued 62 alert notifications known as VONAs (Volcano Observatory Notice for Aviation) to inform the aeronautical authorities about the volcanic activity. We present an automated VONA-based workflow aimed at real-time assessment of the volcanic hazard due to tephra fallout at Mt. Etna. When a VONA reporting tephra emission is issued by INGV-OE, numerical simulations accounting for atmospheric and eruptive uncertainties are automatically initialized to produce probabilistic hazard maps of tephra fallout and atmospheric dispersal. We applied the workflow to three lava fountains that occurred during the 2021 eruptive cycle. To test the modelling results, we compared the simulated ground load with field data, and the extent and position of the simulated volcanic cloud with the observed or estimated volcanic cloud from the Toulouse Volcanic Ash Advisory Center. Overall, we found a good match between simulated and observed quantities (tephra loads and volcanic cloud position), especially when accurate information on eruptive conditions (column height and duration) are supplied by the VONAs. Finally, through a statistical analysis, we found that column height and wind field are fundamental in determining tephra ground accumulation. For this reason, these parameters should be constrained by observational data as accurately as possible when performing numerical simulations, especially in the line of developing operational workflows.
Li–Yau inequalities for the Helfrich functional and applications
Authors: Rupp Fabian , Scharrer Christian 
Published: December 2022

AbstractWe prove a general Li–Yau inequality for the Helfrich functional where the spontaneous curvature enters with a singular volume type integral. In the physically relevant cases, this term can be converted into an explicit energy threshold that guarantees embeddedness. We then apply our result to the spherical case of the variational Canham–Helfrich model. If the infimum energy is not too large, we show existence of smoothly embedded minimizers. Previously, existence of minimizers was only known in the classes of immersed bubble trees or curvature varifolds.
Density of Lipschitz functions in energy
Authors: Eriksson-Bique Sylvester 
Published: December 2022

AbstractIn this paper, we show that the density in energy of Lipschitz functions in a Sobolev space$$N^{1,p}(X)$$N1,p(X)holds for all$$p\in [1,\infty )$$p∈[1,∞)whenever the spaceXis complete and separable and the measure is Radon and positive and finite on balls. Emphatically,$$p=1$$p=1is allowed. We also give a few corollaries and pose questions for future work. The proof is direct and does not involve the usual flow techniques from prior work. It also yields a new approximation technique, which has not appeared in prior work. Notable with all of this work is that we do not use any form of Poincaré inequality or doubling assumption. The techniques are flexible and suggest a unification of a variety of approaches that have appeared in the literature on the topic.
Privacy in targeted advertising on mobile devices: a survey
Authors: Ullah Imdad , Boreli Roksana , Kanhere Salil S. 
Published: December 2022

AbstractTargeted advertising has transformed the marketing landscape for a wide variety of businesses, by creating new opportunities for advertisers to reach prospective customers by delivering personalised ads, using an infrastructure of a number of intermediary entities and technologies. The advertising and analytics companies collect, aggregate, process, and trade a vast amount of users’ personal data, which has prompted serious privacy concerns among both individuals and organisations. This article presents a comprehensive survey of the privacy risks and proposed solutions for targeted advertising in a mobile environment. We outline details of the information flow between the advertising platform and ad/analytics networks, the profiling process, the measurement analysis of targeted advertising based on user’s interests and profiling context, and the ads delivery process, for both in-app and in-browser targeted ads; we also include an overview of data sharing and tracking technologies. We discuss challenges in preserving the mobile user’s privacy that include threats related to private information extraction and exchange among various advertising entities, privacy threats from third-party tracking, re-identification of private information and associated privacy risks. Subsequently, we present various techniques for preserving user privacy and a comprehensive analysis of the proposals based on such techniques; we compare the proposals based on the underlying architectures, privacy mechanisms, and deployment scenarios. Finally, we discuss the potential research challenges and open research issues.
Stand characteristics modulate secondary growth responses to drought and gross primary production in Pinus halepensis afforestation
Authors: Gazol Antonio , Rozas Vicente , Cuende Arribas Sandra , Alonso Ponce Rafael , Rodríguez-Puerta Francisco , Gómez Cristina , Olano José M. 
Published: December 2022

AbstractImpacts of climate warming on forests vigour are forecasted to increase in magnitude. Yet it remains unclear how stand characteristics and competition modulate the relationship between tree growth and gross primary production with drought. Here, we studied how the spatial variation in stand density, basal area and height modulates tree growth (Basal Area Increment, BAI and stand growth), summer NDVI, as well as their responses to drought (Standardized Precipitation-Evapotranspiration Index, SPEI) in 56 Aleppo pine (Pinus halepensis Mill.) planted forests located in Northeast Spain. Long-term BAI responses to SPEI were strongly determined by stand density, suggesting that competition modulates Aleppo pine growth responses to drought. Along this, summer NDVI also displayed strong associations with SPEI. NDVI was mostly related with stand growth, suggesting canopy densification drives NDVI pattern and trends. Short-term BAI and NDVI responses to severe droughts were mainly independent of stand characteristics. In the studied region, drought is a universal factor limiting Aleppo pine secondary growth and canopy greening. However, the results suggest that stand density modulates Aleppo pine growth responses to drought on the long-term, reducing the growth in densest stands. Denser stands with larger trees are the ones that present higher NDVI values, suggesting that canopy activity depends more on stand canopy coverage than on secondary growth rate and its response to drought. In these Mediterranean pines, canopy activity and secondary growth are temporally coupled but spatially decoupled.
Airborne particles, bacterial and fungal communities insights of two museum exhibition halls with diverse air quality characteristics
Authors: Saridaki Aggeliki , Glytsos Thodoros , Raisi Louiza , Katsivela Eleftheria , Tsiamis George , Kalogerakis Nicolas , Lazaridis Mihalis 
Published: December 2022

AbstractAirborne particles, bacteria and fungi consist main determinants of indoor air quality. In this study, these characteristics were investigated in two exhibition halls of the Historical Museum of Crete, in comparison with the outdoor environment. In Zacharias Portalakis (ZP) hall, three air purifiers were operating during museum opening hours, as opposed to El Greco (EG) hall. A significant part of ultrafine (< 1 μm) particles was efficiently removed by the air purifiers in ZP hall. Airborne coarse particles PN2.5–10 were associated with human occupancy in both halls, indicating transportation from visitors and resuspension as possible sources. Average airborne bacterial concentration was also lower in ZP than in EG hall, assessed by both molecular and culture-dependent methods. The bacterial and fungal communities of both indoor halls were distinct from the outdoor counterpart. Micrococcus and Staphylococcus, in terms of bacteria, and Alternaria and Malassezia, in terms of fungi, were the most abundant genera indoors, most of them being human-related. Hierarchical clustering of indoor samples indicated that EG hall bacteria were similar to ZP hall bacteria collected on the same day, but varied between different sampling dates. This observation, together with the bacterial beta-diversity analysis, implied that both indoor halls probably shared common bacterial source(s), while the respective fungal pattern of the two indoor halls was found significantly separated. The outdoor air contribution in EG and ZP hall bacterial profile presented a comparable fluctuation pattern; this was not observed for fungi, probably indicating the complexity of potential sources for different fungal taxa.
A survey on multi-objective hyperparameter optimization algorithms for machine learning
Authors: Morales-Hernández Alejandro , Van Nieuwenhuyse Inneke , Rojas Gonzalez Sebastian 
Published: December 2022

AbstractHyperparameter optimization (HPO) is a necessary step to ensure the best possible performance of Machine Learning (ML) algorithms. Several methods have been developed to perform HPO; most of these are focused on optimizing one performance measure (usually an error-based measure), and the literature on such single-objective HPO problems is vast. Recently, though, algorithms have appeared that focus on optimizing multiple conflicting objectives simultaneously. This article presents a systematic survey of the literature published between 2014 and 2020 on multi-objective HPO algorithms, distinguishing between metaheuristic-based algorithms, metamodel-based algorithms and approaches using a mixture of both. We also discuss the quality metrics used to compare multi-objective HPO procedures and present future research directions.
Bioimpedance spectroscopy for breast cancer-related lymphedema assessment: clinical practice guidelines
Authors: Shah Chirag , Whitworth Pat , Valente Stephanie , Schwarz Graham S. , Kruse Megan , Kohli Manpreet , Brownson Kirstyn , Lawson Laura , Dupree Beth , Vicini Frank A. 
Published: December 2022

Abstract
Purpose
Breast cancer-related lymphedema (BCRL) represents a significant concern for patients following breast cancer treatment, and assessment for BCRL represents a key component of survivorship efforts. Growing data has demonstrated the benefits of early detection and treatment of BCRL. Traditional diagnostic modalities are less able to detect reversible subclinical BCRL while newer techniques such as bioimpedance spectroscopy (BIS) have shown the ability to detect subclinical BCRL, allowing for early intervention and low rates of chronic BCRL with level I evidence. We present updated clinical practice guidelines for BIS utilization to assess for BCRL.

Methods and Results
Review of the literature identified a randomized controlled trial and other published data which form the basis for the recommendations made. The final results of the PREVENT trial, with 3-year follow-up, demonstrated an absolute reduction of 11.3% and relative reduction of 59% in chronic BCRL (through utilization of compression garment therapy) with BIS as compared to tape measurement. This is in keeping with real-world data demonstrating the effectiveness of BIS in a prospective surveillance model. For optimal outcomes patients should receive an initial pre-treatment measurement and subsequently be followed at a minimum quarterly for first 3 years then biannually for years 4–5, then annually as appropriate, consistent with previous guidelines; the target for intervention has been changed from a change in L-Dex of 10 to 6.5. The lack of pre-operative measure does not preclude inclusion in the prospective surveillance model of care.

Conclusion
The updated clinical practice guidelines present a standardized approach for a prospective model of care using BIS for BCRL assessment and supported by evidence from a randomized controlled trial as well as real-world data.
Assessing the opportunity of combining state-of-the-art Android malware detectors
Authors: Daoudi Nadia , Allix Kevin , Bissyandé Tegawendé F. , Klein Jacques 
Published: December 2022

AbstractResearch on Android malware detection based on Machine learning has been prolific in recent years. In this paper, we show, through a large-scale evaluation of four state-of-the-art approaches that their achieved performance fluctuates when applied to different datasets. Combining existing approaches appears as an appealing method to stabilise performance. We therefore proceed to empirically investigate the effect of such combinations on the overall detection performance. In our study, we evaluated 22 methods to combine feature sets or predictions from the state-of-the-art approaches. Our results showed that no method has significantly enhanced the detection performance reported by the state-of-the-art malware detectors. Nevertheless, the performance achieved is on par with the best individual classifiers for all settings. Overall, we conduct extensive experiments on the opportunity to combine state-of-the-art detectors. Our main conclusion is that combining state-of-the-art malware detectors leads to a stabilisation of the detection performance, and a research agenda on how they should be combined effectively is required to boost malware detection. All artefacts of our large-scale study (i.e., the dataset of $\sim $
∼
0.5 million apks and all extracted features) are made available for replicability.
Aggregation in an Infinite, Relativistic Universe
Authors: Wilkinson Hayden 
Published: December 2022

AbstractAggregative moral theories face a series of devastating problems when we apply them in a physically realistic setting. According to current physics, our universe is likely infinitely large, and will contain infinitely many morally valuable events. But standard aggregative theories are ill-equipped to compare outcomes containing infinite total value. So, applied in a realistic setting, they cannot compare any outcomes a real-world agent must ever choose between. This problem has been discussed extensively, and non-standard aggregative theories proposed to overcome it. This paper addresses a further problem of similar severity. Physics tells us that, in our universe, how remotely in time an event occurs is relative. But our most promising aggregative theories, designed to compare outcomes containing infinitely many valuable events, are sensitive to how remote in time those events are. As I show, the evaluations of those theories are then relative too. But this is absurd; evaluations of outcomes must be absolute! So we must reject such theories. Is this objection fatal for all aggregative theories, at least in a relativistic universe like ours? I demonstrate here that, by further modifying these theories to fit with the physics, we can overcome it.
Technomoral Resilience as a Goal of Moral Education
Authors: Bauer Katharina , Hermann Julia 
Published: December 2022

AbstractIn today’s highly dynamic societies, moral norms and values are subject to change. Moral change is partly driven by technological developments. For instance, the introduction of robots in elderly care practices requires caregivers to share moral responsibility with a robot (see van Wynsberghe 2013). Since we do not know what elements of morality will change and how they will change (see van der Burg 2003), moral education should aim at fostering what has been called “moral resilience” (Swierstra 2013). We seek to fill two gaps in the existing literature: (i) research on moral education has not paid enough attention to the development of moral resilience; (ii) the very limited literature on moral resilience does not conceptualise moral resilience in relation to new technological developments. We argue that philosophical accounts of moral education need to do justice to the importance of moral resilience, and that a specific form of moral resilience should be conceptualised as “technomoral resilience” to underline the added value of cultivating moral resilience in relation to technomoral change. We illustrate the role of technomoral resilience in practice by looking at the context of elderly care. To make the first step towards an account of how technomoral resilience can be fostered in moral education, we propose that moral education shall focus on a triangle of capacities: (1) moral imagination, (2) a capacity for critical reflection, and (3) a capacity for maintaining one’s moral agency in the face of disturbances.