bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anisotropic Schrödinger black holes with hyperscaling-violation
Authors: Herrera-Aguilar Alfredo , Herrera-Mendoza Jhony A. , Higuita-Borja Daniel F. , Méndez-Zavaleta Julio A. , Romero-Figueroa Carlos Eduardo 
Published: April 2023

AbstractWe investigate novel exact solutions to an Einstein–Maxwell theory non-minimally coupled to a self-interacting dilaton-like scalar. Extending the results of Herrera-Aguilar et al. (Phys. Rev. D 103(12):124025, 2021. arXiv:2012.13412 [hep-th]; arXiv:2110.04445 [hep-th]), we report three families of exact configurations over a non-relativistic Schrödinger background with both, arbitrary dynamical critical exponent z and hyperscaling violating parameter $$\theta $$
θ
in any dimension d. Concretely, we provide field configurations with hyperscaling violation which are locally Schrödinger spaces. Our solutions correspond to three kinds: a zero-temperature background, a naked singularity and, more interestingly, a family of black holes. To the latter, we construct the corresponding Carter–Penrose diagram with a view to understand their causal structure given the non-standard background. We show that a non-trivial hyperscaling violation parameter $$\theta $$
θ
is necessary in order to support a real non-constant dilaton field in the configuration. We explore how the relation between the hyperscaling violation parameter and the critical dynamical exponent determine, in combination with the spacetime dimension, the kinematic aspects of the fields. A further refinement on the physically sensible configurations is obtained from the study of the null energy conditions. We provide a thorough study of the thermodynamics including the quasi-local computation of charges and the verification of the first law. We explore the effects in the thermodynamics from varying the rich parameter space, paying special attention in comparing the qualitative behavior of the thermodynamics of the scalar-free solutions and the ones with a nontrivial dilaton. Lastly, it is found that if the reality condition is loosen up on the scalar, the configuration is prone to acquiring a scalar charge.
Improved factorization for threshold resummation in heavy quark to heavy quark decays
Authors: Aglietti U. G. , Ferrera G. 
Published: April 2023

AbstractWe consider the resummation of soft-gluon effects in heavy quark to heavy quark decays, namely the processes $$Q_1 \rightarrow Q_2 \, + \, \mathrm {(non\,QCD\, partons)}$$

Q
1

→

Q
2

+

(
non

QCD

partons
)

, where $$Q_1$$

Q
1

and $$Q_2$$

Q
2

are two different heavy quarks. We construct a new factorization scheme for threshold resummed spectra, which allows us to consistently evaluate the distribution of the final hadron invariant mass $$m_X$$

m
X

in all the kinematic regions, i.e. when $$m_X$$

m
X

is smaller, of the same order, or larger than the mass of the final quark $$Q_2$$

Q
2

. A dependence of the improved Coefficient function on the threshold variable is introduced, which can however be relegated to a small interval of this variable by means of the so-called Partition of Unity. We explicitly apply our improved scheme to the $$b \rightarrow X_s \, + \gamma $$

b
→

X
s

+
γ

decay at next-to-leading logarithmic accuracy.
Lie group analysis of the general Karmarkar condition
Authors: Maharaj Sunil D. , Naidoo Noeleen , Amery Gareth , Govinder Keshlan S. 
Published: April 2023

AbstractThe Karmarkar embedding condition in different spherically symmetrical metrics is studied in general using Lie symmetries. In this study, the Lie symmetries for conformally flat and shear-free metrics are studied which extend recent results. The Lie symmetries for geodesic metrics and general spherical spacetimes are also obtained for the first time. In all cases group invariant exact solutions to the Karmarkar embedding condition are obtained via a Lie group analysis. It is further demonstrated that the Karmarkar condition can be used to produce a model with interesting features: an embeddable relativistic radiating star with a barotropic equation of state via Lie symmetries.
NNLO QCD predictions for Z-boson production in association with a charm jet within the LHCb fiducial region
Authors: Gauld R. , Gehrmann–De Ridder A. , Glover E. W. N. , Huss A. , Rodriguez Garcia A. , Stagnitto G. 
Published: April 2023

AbstractWe compute next-to-next-to-leading order (NNLO) QCD corrections to neutral vector boson production in association with a charm jet at the LHC. This process is studied in the forward kinematics at $$\sqrt{s}=13$$

s

=
13

TeV, which may provide valuable constraints on the intrinsic charm component of the proton. A comparison is performed between fixed order and NLO predictions matched to a parton shower showing mutual compatibility within the respective uncertainties. NNLO corrections typically lead to a reduction of theoretical uncertainties by a factor of two and the perturbative convergence is further improved through the introduction of a theory-inspired constraint on the transverse momentum of the vector boson plus jet system. A comparison between these predictions with data will require an alignment of a flavour-tagging procedure in theory and experiment that is infrared and collinear safe.
Leveraging the Community Structure of a Social Network for Maximizing the Spread of Influence
Authors: Umrawal Abhishek K. , Aggarwal Vaneet 
Published: April 2023

We consider the problem of Influence Maximization (IM), the task of selecting k seed nodes in a social network such that the expected number of nodes influenced is maximized. We propose a community-aware divide-and-conquer framework that involves (i) learning the inherent community structure of the social network, (ii) generating candidate solutions by solving the influence maximization problem for each community, and (iii) selecting the final set of seed nodes using a novel progressive budgeting scheme.
Our experiments on a real-world social network show that the proposed framework outperforms the standard methods in terms of run-time and the heuristic methods in terms of influence.
Elevated LDL Cholesterol Increases Microvascular Endothelial VWF and Thromboinflammation After Myocardial Infarction
Authors: Ozawa Koya , Packwood William , Varlamov Oleg , Muller Matthew , Xie Aris , Wu Melinda D. , Abraham-Fan Rue-Jen , López José A. , Lindner Jonathan R. 
Published: April 2023

Background:
In reperfused myocardial infarction, VWF (von Willebrand factor)-mediated platelet adhesion contributes to impaired microvascular reflow and possibly also to postmyocardial infarction inflammation. We hypothesized that postischemic thromboinflammatory processes are worsened by elevated LDL (low-density lipoprotein) cholesterol.

Methods:
Myocardial ischemia-reperfusion or sham procedure was performed in wild-type mice and hyperlipidemic mice deficient for the LDL receptor and Apobec-1 (apolipoprotein-B mRNA editing enzyme catalytic polypeptide-1; DKO [double knockout]). DKO subgroups were treated with N-acetylcysteine, which inhibits pro-adhesive VWF multimers or with recombinant ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motifs-13), which enzymatically cleaves endothelial surface-associated VWF. Myocardial contrast echocardiography perfusion imaging and molecular imaging for VWF, platelet glycoprotein Ibα, and leukocyte CD18 (cluster of differentiation) were performed 30 minutes post-reperfusion. Histology, infarct sizing, and echocardiography were performed at 1.5 or 72 hours; late echocardiography was performed at day 21.

Results:

After ischemia-reperfusion, DKO compared with wild-type mice had ≈2-fold higher (
P
<0.05) risk area signal for microvascular platelet adhesion, VWF, and CD18; greater impairment in microvascular reflow, and 2-fold larger infarct size. Treatment of DKO mice with N-acetylcysteine and ADAMTS13 reduced molecular imaging signal for microvascular platelet adhesion, VWF, and CD18; improved early microvascular reflow; and reduced eventual infarct size. ADAMTS13 suppressed the postmyocardial infarction neutrophil and monocyte infiltration, enhanced the time-dependent recovery of left ventricular systolic function, and prevented late left ventricular remodeling.

Conclusions:
In reperfused myocardial infarction, elevated LDL cholesterol promotes thromboinflammation through excess microvascular endothelial VWF and platelet adhesion, resulting in less microvascular reflow and larger infarct size. In the presence of elevated LDL cholesterol, therapies that suppress endothelial-associated VWF can promote recovery of left ventricular function and protect against remodeling.
Effect of Total SMS Activity on LDL Catabolism in Mice
Authors: Li Zhiqiang , He Mulin , Chen Guangzhi , Souaiaia Tade , Worgall Tilla S. , Jiang Xian-Cheng 
Published: April 2023

Background:
Sphingomyelin (SM) and cholesterol are 2 key lipid partners on cell membranes and on lipoproteins. Many studies have indicated the influence of cholesterol on SM metabolism. This study examined the influence of SM biosynthesis on cholesterol metabolism.

Methods:

Inducible global
Sms1
KO (knockout)/global
Sms2
KO mice were prepared to evaluate the effect of whole-body SM biosynthesis deficiency on lipoprotein metabolism. Tissue cholesterol, SM, ceramide, and glucosylceramide levels were measured. Triglyceride production rate and LDL (low-density lipoprotein) catabolism were measured. Lipid rafts were isolated and LDL receptor mass and function were evaluated. Also, the effects of exogenous sphingolipids on hepatocytes were investigated.

Results:
We found that total SMS (SM synthase) depletion significantly reduced plasma SM levels. Also, the total deficiency significantly induced plasma cholesterol, apoB (apolipoprotein B), and apoE (apolipoprotein E) levels. Importantly, total SMS deficiency, but not SMS2 deficiency, dramatically decreased LDL receptors in the liver and attenuated LDL uptake through the receptor. Further, we found that total SMS deficiency greatly reduced LDL receptors in the lipid rafts, which contained significantly lower SM and significantly higher glucosylceramide, as well as cholesterol. Furthermore, we treated primary hepatocytes and Huh7 cells (a human hepatoma cell line) with SM, ceramide, or glucosylceramide, and we found that only SM could upregulate LDL receptor levels in a dose-dependent fashion.

Conclusions:
Whole-body SM biosynthesis plays an important role in LDL cholesterol catabolism. The total SMS deficiency, but not SMS2 deficiency, reduces LDL uptake and causes LDL cholesterol accumulation in the circulation. Given the fact that serum SM level is a risk factor for cardiovascular diseases, inhibiting SMS2 but not SMS1 should be the desirable approach.
Variability in Nonvitamin K Oral Anticoagulant Dose Eligibility and Adjustment According to Renal Formulae and Clinical Outcomes in Patients With Atrial Fibrillation With and Without Chronic Kidney Disease: Insights From ORBIT‐AF II
Authors: Yao Ren Jie Robert , Holmes DaJuanicia N. , Andrade Jason G. , Levin Adeera , Piccini Jonathan P. , Fordyce Christopher B. 
Published: April 2023

Background
Nonvitamin K oral anticoagulants require dose adjustment based on kidney function.The most common estimate of kidney function employed in clinical practice is estimated glomerular filtration rate (eGFR); however, product monographs recommend the use of the Cockcroft‐Gault estimated creatinine clearance (eCrCl) for dose adjustment.

Methods and Results

The authors included patients enrolled in the ORBIT‐AF II (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation AF II) trial. Dosing was considered inappropriate when use of eGFR resulted in a lower (undertreatment) or higher (overtreatment) dose than that recommended by the eCrCl. The primary outcome of major adverse cardiovascular and neurological events was a composite of cardiovascular death, stroke or systemic embolism, new‐onset heart failure, and myocardial infarction. Among 8727 in the overall cohort, agreement between eCrCl and eGFR was observed in 93.5% to 93.8% of patients. Among 2184 patients with chronic kidney disease (CKD), the agreement between eCrCl and eGFR was 79.9% to 80.7%. Dosing misclassification was more frequent in the CKD population (41.9% of rivaroxaban users, 5.7% of dabigatran users, and 4.6% apixaban users). At 1 year, undertreated patients in the CKD group had significantly greater major adverse cardiovascular and neurological events (adjusted hazard ratio, 2.93 [95% CI, 1.08–7.92]) compared with the group with appropriate nonvitamin K oral anticoagulants dosing (
P
=0.03).

Conclusions
The prevalence of misclassification of nonvitamin K oral anticoagulants dosing was high when using eGFR, particularly among patients with CKD. Among patients with CKD, potential undertreatment due to inappropriate and off‐label renal formulae may result in worse clinical outcomes. These findings highlight the importance of using eCrCl, and not eGFR, for dose adjustment in all patients with AF receiving nonvitamin K oral anticoagulants.
Impact of Neighborhood Socioeconomic Status on Outcomes Following First‐Stage Palliation of Single Ventricle Heart Disease
Authors: Sengupta Aditya , Bucholz Emily M. , Gauvreau Kimberlee , Newburger Jane W. , Schroeder Margaret , Kaza Aditya K. , del Nido Pedro J. , Nathan Meena 
Published: April 2023

Background
The impact of neighborhood socioeconomic status (SES) on outcomes following first‐stage palliation of single ventricle heart disease remains incompletely characterized.

Methods and Results

This was a single‐center, retrospective review of consecutive patients who underwent the Norwood procedure from January 1, 1997 to November 11, 2017. Outcomes of interest included in‐hospital (early) mortality or transplant, postoperative hospital length‐of‐stay, inpatient cost, and postdischarge (late) mortality or transplant. The primary exposure was neighborhood SES, assessed using a composite score derived from 6 US census‐block group measures related to wealth, income, education, and occupation. Associations between SES and outcomes were assessed using logistic regression, generalized linear, or Cox proportional hazards models, adjusting for baseline patient‐related risk factors. Of 478 patients, there were 62 (13.0%) early deaths or transplants. Among 416 transplant‐free survivors at hospital discharge, median postoperative hospital length‐of‐stay and cost were 24 (interquartile range, 15–43) days and $295 000 (interquartile range, $193 000–$563 000), respectively. There were 97 (23.3%) late deaths or transplants. On multivariable analysis, patients in the lowest SES tertile had greater risk of early mortality or transplant (odds ratio [OR], 4.3 [95% CI, 2.0–9.4;
P
<0.001]), had longer hospitalizations (coefficient 0.4 [95% CI, 0.2–0.5;
P
<0.001]), incurred higher costs (coefficient 0.5 [95% CI, 0.3–0.7;
P
<0.001]), and had greater risk of late mortality or transplant (hazard ratio, 2.2 [95% CI, 1.3–3.7;
P
=0.004]), compared with those in the highest tertile. The risk of late mortality was partially attenuated with successful completion of home monitoring programs.

Conclusions
Lower neighborhood SES is associated with worse transplant‐free survival following the Norwood operation. This risk persists throughout the first decade of life and may be mitigated with successful completion of interstage surveillance programs.
Remote Cardiovascular Hypertension Program Enhanced Blood Pressure Control During the COVID‐19 Pandemic
Authors: Lee Simin Gharib , Blood Alexander J. , Cannon Christopher P. , Gordon William J. , Nichols Hunter , Zelle David , Scirica Benjamin M. , Fisher Naomi D. L. 
Published: April 2023

Background
The COVID‐19 pandemic disrupted traditional health care; one fallout was a drastic decrease in blood pressure (BP) assessment. We analyzed the pandemic's impact on our existing remote hypertension management program's effectiveness and adaptability.

Methods and Results

This retrospective observational analysis evaluated BP control in an entirely remote management program before and during the pandemic. A team of pharmacists, nurse practitioners, physicians, and nonlicensed navigators used an evidence‐based clinical algorithm to optimize hypertensive treatment. The algorithm was adapted during the pandemic to simplify BP control. Overall, 1256 patients (605 enrolled in the 6 months before the pandemic shutdown in March 2020 and 651 in the 6 months after) were a median age of 63 years old, 57% female, and 38.2% non‐White. Among enrolled patients with sustained hypertension, 51.1% reached BP goals. Within this group, rates of achieving goal BP improved to 94.6% during the pandemic from 75.8% prepandemic (
P
<0.0001). Mean baseline home BP was 141.7/81.9 mm Hg during the pandemic and 139.8/82.2 prepandemic, and fell ≈16/9 mm Hg in both periods (
P
<0.0001). Maintenance during the pandemic was achieved earlier (median 11.8 versus 19.6 weeks,
P
<0.0001), with more frequent monthly calls (8.2 versus 3.1,
P
<0.0001) and more monthly home BP recordings per patient (32.4 versus 18.9,
P
<0.0001), compared with the prepandemic period.

Conclusions
A remote clinical management program was successfully adapted and delivered significant improvements in BP control and increased home BP monitoring despite a nationally observed disruption of traditional hypertension care. Such programs have the potential to transform hypertension management and care delivery.
Association of Objective and Self‐Reported Sleep Duration With All‐Cause and Cardiovascular Disease Mortality: A Community‐Based Study
Authors: Zhao Binbin , Meng Yuxuan , Jin Xiaoying , Xi Wenyu , Ma Qingyan , Yang Jian , Ma Xiancang , Yan Bin 
Published: April 2023

Background
Previous studies found an association between self‐reported sleep duration and mortality. This study aimed to compare the effects of objective and self‐reported sleep duration on all‐cause and cardiovascular disease (CVD) mortality.

Methods and Results
A total of 2341 men and 2686 women (aged 63.9±11.1 years) were selected from the SHHS (Sleep Heart Health Study). Objective sleep duration was acquired using in‐home polysomnography records, and self‐reported sleep duration on weekdays and weekends was based on a sleep habits questionnaire. The sleep duration was categorized as ≤4 hours, 4 to 5 hours, 5 to 6 hours, 6 to 7 hours, 7 to 8 hours, and >8 hours. Multivariable Cox regression analysis was used to investigate the association of objective and self‐reported sleep duration with all‐cause and CVD mortality. During a mean follow‐up period of 11 years, 1172 (23.3%) participants died, including 359 (7.1%) deaths from CVD. All‐cause and CVD mortality rates decreased gradually with increasing objective sleep duration. In multivariable Cox regression analysis, the greatest association for all‐cause and CVD mortality was with an objective sleep duration of 5 hours or shorter. In addition, we found a J‐shaped association of self‐reported sleep duration on both weekdays and weekends with all‐cause and CVD mortality. Self‐reported short (≤4 hours) and long (>8 hours) sleep duration on weekdays and weekends were associated with an increased risk of all‐cause and CVD mortality compared with 7 to 8 hours sleep duration. Furthermore, a weak correlation was observed between objective and self‐reported sleep duration.

Conclusions
This study showed that both objective and self‐reported sleep duration were associated with all‐cause and CVD mortality, but with different characteristics.

Registration

URL:
https://clinicaltrials.gov/ct2/show/NCT00005275
; Unique identifier: NCT00005275.
QRS Fragmentation in Preserved Ejection Fraction Heart Failure: Functional Insights, Pathological Correlates, and Prognosis
Authors: Sung Kuo‐Tzu , Chang Sheng‐Hsiung , Chi Po‐Ching , Chien Shih‐Chieh , Lo Chi‐In , Lin Chao‐Feng , Huang Wen‐Hung , Yun Chun‐Ho , Tsai Cheng‐Ting , Su Cheng‐Huang , Hou Charles Jia‐Yin , Yeh Hung‐I , Tsao Chin‐Ho , Kuo Jen‐Yuan , Hung Chung‐Lieh 
Published: April 2023

Background
Fragmented QRS (fQRS) morphology as a surrogate marker of the possible presence of myocardial scarring has been shown to confer a higher risk in patients with reduced ejection fraction heart failure. We aimed to investigate the pathophysiological correlates and prognostic implications of fQRS in patients with heart failure with preserved ejection fraction (HFpEF).

Methods and Results

We consecutively studied 960 patients with HFpEF (76.4±12.7 years, men: 37.2%). fQRS was assessed using a body surface ECG during hospitalization. QRS morphology was available and classified into 3 categories among 960 subjects with HFpEF as non‐fQRS, inferior fQRS, and anterior/lateral fQRS groups. Despite comparable clinical features in most baseline demographics among the 3 fQRS categories, anterior/lateral fQRS showed significantly higher B‐type natriuretic peptide/troponin levels (both
P
<0.001), with both the inferior and anterior/lateral fQRS HFpEF groups demonstrating a higher degree of unfavorable cardiac remodeling, greater extent of myocardial perfusion defect, and slower coronary flow phenomenon (all
P
<0.05). Patients with anterior/lateral fQRS HFpEF exhibited significantly altered cardiac structure/function and more impaired diastolic indices (all
P
<0.05). During a median of 657 days follow‐up, the presence of anterior/lateral fQRS conferred a doubled HF re‐admission risk (adjusted hazard ratio 1.90,
P
<0.001), with both inferior and anterior/lateral fQRS having a higher risk of cardiovascular and all‐cause death (all
P
<0.05) by using Cox regression models.

Conclusions
The presence of fQRS in HFpEF was associated with more extensive myocardial perfusion defects and worsened mechanics, which possibly denotes a more severe involvement of cardiac damage. Early recognition in such patients with HFpEF likely benefits from targeted therapeutic interventions.
Travelling with Architect Erik Hansen: A Cypress on the Peloponnese
Authors: Algreen-Ussing Gregers 
Published: April 2023

Abstract
This reflective article starts with a personal anecdote, a journey together with Erik Hansen on the Peloponnese to visit an old cypress. He describes Hansen’s empathetic working method, which leads to a better understanding of the whole construction process of the temple. An essential part was the building of an evenly ascending slipway on the steep hillside, which could comply with the limits of the tractive force and the load put on the constructed track by the transport of the building blocks and wooden beams. This slipway was used to transport around 2,000 building blocks with a total volume of more than 3,000 m3. The total dragging operation included over 8,000 tons of blue-grey limestone.
Erik Hansen: The Man Who Speaks with the Stones
Authors: Tae Jensen Jesper 
Published: April 2023

Abstract
In this brief contribution, we are introduced to two of Erik Hansen’s restoration works in Denmark, the Marble Bridge across Frederiksholm’s Canal (erected 1739–1745) and his private house in Wildersgade (built ca. 1725), both in Copenhagen. These two examples demonstrate Hansen’s unique approach to architecture, in which he literarily is “The Man Who Speaks with the Stones.”
The Stoa of Eumenes in Athens: Theoretical Restoration
Authors: Korres Manolis 
Published: April 2023

Abstract
The article offers a detailed discussion of the outline and all essential elements of the Stoa of Eumenes at Athens. It is a preliminary study for a more trustworthy reconstruction of this central architectural monument. Themes discussed are Doric columns, Ionic columns, Pergamene columns, double half-columns, examines the height of all architectural orders, prefabrication with Prokonnesian marble, and issues of transport, letters as mason marks, important horizontal dimensions, construction of the floor, particularities of the roof geison, roof type, diagonal beams, corner supports under diagonal beams, alterations on the stoa’s west end, and the reuse of geison blocks on the proskenion of the Dionysos Theater.