bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-COVID interstitial lung disease in symptomatic patients after COVID-19 disease
Authors: Fesu Dorottya , Polivka Lorinc , Barczi Eniko , Foldesi Marcell , Horvath Gabor , Hidvegi Edit , Bohacs Aniko , Muller Veronika 
Published: March 2023

AbstractCOVID-19 is often associated with long-lasting pulmonary symptoms. Data are scarce about interstitial lung disease (ILD) in patients following COVID-19 hospitalization with persistent symptoms. We retrospectively reviewed all cases sent to pulmonary post-COVID evaluation due to persistent symptoms between February 2021 and February 2022 (N = 318). All patients with suspected ILD (N = 44) were reviewed at the multidisciplinary discussion. Patient characteristics, symptoms, time since hospitalization, detailed lung function measurements and 6-min walk test (6MWT) were evaluated. The post-COVID ILD suspected group included more men (68.2 vs. 31.8%) with significantly older age compared to the control group (64.0 ± 12.3 vs. 51.3 ± 14.9 years). Most patient needed hospital care for COVID-19 pneumonia (68.6% of all patients and 84.1% of ILD suspected group) and average time since hospitalization was 2.4 ± 2.3 months. Persisting symptoms included fatigue (34%), dyspnoea (25.2%), cough (22.6%), and sleep disorders (insomnia 13.2%; sleepiness 8.2%). Post-COVID ILD presented more often with new symptoms of cough and sleepiness. Functional impairment, especially decreased walking distance and desaturation during 6-min walk test (6MWT) were detected in the ILD-suspected group. Respiratory function test in the post-COVID ILD group showed slight restrictive ventilatory pattern (FVC: 76.7 ± 18.1%, FEV1: 83.5 ± 19.1%, TLC: 85.6 ± 28.1%) and desaturation during 6MWT were detected in 41% of patients. LDCT changes were mainly ground glass opacities (GGO) and/or reticular abnormalities in most cases affecting < 10% of the lungs. Our data indicate that suspected post-COVID ILD is affecting 13.8% of symptomatic patients. High resolution chest CT changes were mainly low extent GGO/reticulation, while long-term lung structural changes need further evaluation.
Nanoporous carbon doped with metal oxide microsphere as renewable flame retardant for integrating high flame retardancy and antibacterial properties of thermoplastic polymer composites
Authors: Attia Nour F. 
Published: March 2023

AbstractInnovative, renewable and cost-effective porous composites were developed for integrating high fire safety and antibacterial properties for thermoplastic polymers. Sustainable porous carbon sheets were developed from plum stones as fruits-by-products via single carbonization step affording dual environmental and economic benefits. The as-developed porous carbon own specific surface area of 165 m2 g−1 which is characteristic of mesoporous feature of an average mesopore size of 2.1 nm, in addition to naturally doped nitrogen species. The obtained porous carbons sheets were dispersed in different mass loadings in to polystyrene matrix-producing polymer composites. Interestingly, SnO2 microsphere of an average size of 2 µm was synthesized on the surface of developed porous carbon sheets producing new porous composites. The new composites were elucidated using XRD, FT-IR and SEM–EDS. Then, the developed composites were dispersed in polystyrene. The mass loadings were altered and studied. The progress in fire safety, thermal stability and antibacterial properties for developed polymer composites was studied. The flame retardancy of the new composites was significantly improved achieving rate of burning of 20.5 mm min−1 compared to 46.5 mm min−1 for blank polymer. This superior flame retardancy was corroborated by recording LOI value of 24.5% compared to 18% for virgin polymer. This attained flame retardancy was ascribed to the synergistic effect between porous carbon sheets contained nitrogen and SnO2 microsphere. The new composites afford promising inhibition for bacterial growth achieving clear antibacterial inhibition zone of 11 mm compared to zero for blank sample. The flame retardancy action was studied and elucidated.
Online group projects in higher education: persistent challenges and implications for practice
Authors: Donelan Helen , Kear Karen 
Published: March 2023

AbstractWith the rapid adoption of online learning across higher education, there is an urgent need to identify its challenges and ways of addressing them. Online group projects, in particular, present significant issues for educators. This paper presents the findings of a systematic literature review identifying the key challenges of online group projects, together with strategies to address them. From a corpus of 114 recent papers, the 57 most relevant were analysed, to identify themes related to challenges and strategies. Key challenges were: low and uneven participation by students; a lack of clarity and preparation for students; and poor relationships. Strategies for addressing challenges were: careful design of projects, particularly regarding fair assessment; clear guidance and preparation of students; and practical and emotional support throughout, to encourage confidence and engagement. The findings of this review will enable educators to design and facilitate online group projects which students find rewarding and valuable.
Measuring the Impact of R&D&I Subsidies on Innovative Inputs and Outputs in Polish Manufacturing Firms
Authors: Yaghi Adriana Zabłocka-Abi , Tomaszewski Tomasz 
Published: March 2023

AbstractThis research investigates the impact of R&D and innovation (R&D&I) subsidies on the innovative inputs and outputs of Polish manufacturing companies. We combine unique survey data that incorporates a representative sample of Polish manufacturing companies with data on the state aid from the State Aid Data Sharing System (SUDOP). Our results confirm the positive role of R&D&I subsidies on the likelihood of applying for a patent, filing for intellectual property protection for utility models, industrial designs, trademark registrations, and the introduction of process innovations, consistent with the existing literature. However, the results also indicate an insignificant impact of the intervention on firms’ R&D expenditures and product innovations. The extension of the analysis with the moderating effects of internal factors that affect the firms’ innovative behavior indicates that the R&D&I subsidies for exporters lead to the crowding-out effect and for non-exporters generate additional R&D expenditures and increase the propensity for R&D cooperation. Furthermore, R&D&I support for enterprises with foreign ownership reduces their propensity for patent applications and product innovations. In contrast, for beneficiaries with a predominance of domestic capital, it positively impacts many output variables.
The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment of wound infections
Authors: Ryan Aoibhín , Patel Pratikkumar , Ratrey Poonam , O’Connor Paula M. , O’Sullivan Julie , Ross R. Paul , Hill Colin , Hudson Sarah P. 
Published: March 2023

AbstractChronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the healing of chronic wounds. Lacticin 3147 is a two-peptide chain bacteriocin produced by Lactococcus lactis that is active against S. aureus including MRSA strains. Previously, poor physicochemical properties of the peptides were overcome by the encapsulation of lacticin 3147 into solid lipid nanoparticles. Here, a lacticin 3147 solid lipid nanoparticle gel is proposed as a topical treatment for S. aureus and MRSA wound infections. Initially, lacticin 3147’s antimicrobial activity against S. aureus was determined before encapsulation into solid lipid nanoparticles. An optimised gel formulation with the desired physicochemical properties for topical application was developed, and the lacticin-loaded solid lipid nanoparticles and free lacticin 3147 aqueous solution were incorporated into separate gels. The release of lacticin 3147 from both the solid lipid nanoparticle and free lacticin gels was measured where the solid lipid nanoparticle gel exhibited increased activity for a longer period (11 days) compared to the free lacticin gel (9 days). Both gels displayed potent activity ex vivo against S. aureus-infected pig skin with significant bacterial eradication (> 75%) after 1 h. Thus, a long-acting potent lacticin 3147 solid lipid nanoparticle gel with the required physicochemical properties for topical delivery of lacticin 3147 to the skin for the potential treatment of S. aureus-infected chronic wounds was developed.
Graphical abstract
Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria
Authors: Jung Anna Lena , Møller Jørgensen Malene , Bæk Rikke , Artho Marie , Griss Kathrin , Han Maria , Bertrams Wilhelm , Greulich Timm , Koczulla Rembert , Hippenstiel Stefan , Heider Dominik , Suttorp Norbert , Schmeck Bernd 
Published: March 2023

Abstract
Purpose
Malaria is a life-threatening mosquito-borne disease caused by Plasmodium parasites, mainly in tropical and subtropical countries. Plasmodium falciparum (P. falciparum) is the most prevalent cause on the African continent and responsible for most malaria-related deaths globally. Important medical needs are biomarkers for disease severity or disease outcome. A potential source of easily accessible biomarkers are blood-borne small extracellular vesicles (sEVs).

Methods
We performed an EV Array to find proteins on plasma sEVs that are differentially expressed in malaria patients. Plasma samples from 21 healthy subjects and 15 malaria patients were analyzed. The EV array contained 40 antibodies to capture sEVs, which were then visualized with a cocktail of biotin-conjugated CD9, CD63, and CD81 antibodies.

Results
We detected significant differences in the protein decoration of sEVs between healthy subjects and malaria patients. We found CD106 to be the best discrimination marker based on receiver operating characteristic (ROC) analysis with an area under the curve of > 0.974. Additional ensemble feature selection revealed CD106, Osteopontin, CD81, major histocompatibility complex class II DR (HLA-DR), and heparin binding EGF like growth factor (HBEGF) together with thrombocytes to be a feature panel for discrimination between healthy and malaria. TNF-R-II correlated with HLA-A/B/C as well as CD9 with CD81, whereas Osteopontin negatively correlated with CD81 and CD9. Pathway analysis linked the herein identified proteins to IFN-γ signaling.

Conclusion
sEV-associated proteins can discriminate between healthy individuals and malaria patients and are candidates for future predictive biomarkers.

Trial registration
The trial was registered in the Deutsches Register Klinischer Studien (DRKS-ID: DRKS00012518).
Mechanoluminescent-Triboelectric Bimodal Sensors for Self-Powered Sensing and Intelligent Control
Authors: Zhou Bo , Liu Jize , Huang Xin , Qiu Xiaoyan , Yang Xin , Shao Hong , Tang Changyu , Zhang Xinxing 
Published: March 2023

Abstract
Self-powered flexible devices with skin-like multiple sensing ability have attracted great attentions due to their broad applications in the Internet of Things (IoT). Various methods have been proposed to enhance mechano-optic or electric performance of the flexible devices; however, it remains challenging to realize the display and accurate recognition of motion trajectories for intelligent control. Here, we present a fully self-powered mechanoluminescent-triboelectric bimodal sensor based on micro-nanostructured mechanoluminescent elastomer, which can patterned-display the force trajectories. The deformable liquid metals used as stretchable electrode make the stress transfer stable through overall device to achieve outstanding mechanoluminescence (with a gray value of 107 under a stimulus force as low as 0.3 N and more than 2000 cycles reproducibility). Moreover, a microstructured surface is constructed which endows the resulted composite with significantly improved triboelectric performances (voltage increases from 8 to 24 V). Based on the excellent bimodal sensing performances and durability of the obtained composite, a highly reliable intelligent control system by machine learning has been developed for controlling trolley, providing an approach for advanced visual interaction devices and smart wearable electronics in the future IoT era.
Calcined Palygorskites as Supplementary Cementitious Materials
Authors: Poussardin Victor , Roux Valentin , Wilson William , Paris Michael , Tagnit-Hamou Arezki , Deneele Dimitri 
Published: March 2023

AbstractReducing the environmental footprint of cement is an absolute necessity to meet the commitments of COP26 and to limit global warming to + 1.5°C compared to the pre-industrial level. In this context, particular interest has developed in recent years in the use of calcined clays as supplementary cementitious materials (SCMs). Due to their high reactivity, large reserves and homogeneous distribution on the earth's surface, calcined clays represent a viable alternative to conventional SCMs. Clay minerals are highly variable and numerous, each with their own characteristics. As a result, not all of them have potential for use as SCMs. The present paper investigated the use of palygorskite (a clay that has been relatively poorly studied) as an SCM. Two commercial palygorskites of different grades were selected and their calcination was studied by X-ray diffraction and pozzolanic activity tests. Blended cements incorporating 20% of each calcined palygorskite were prepared and the mechanical performance and resistivity of the mortars measured. The results show that the optimum calcination temperature is 800°C (allowing complete amorphization of the clay fraction and the highest pozzolanic reactivity) for both clays. Mortars made with 80% ordinary Portland cement (OPC) blended with 20% of 800°C calcined palygorskite allowed a significant increase in compressive strength and electrical resistivity compared to the reference (100% OPC). The clay sample with palygorskite as the dominant mineral exhibited the greatest pozzolanic reactivity and mechanical performance in cementitious systems, confirming that palygorskite is a clay mineral with a significant potential for a use as a SCM. The second sample with smaller palygorskite content also allowed a significant increase in mechanical performance. This demonstrated that it is not necessary to use high-purity samples and enhances the value of this type of material.
The “What About Me?” Question in ICJ Proceedings On Compensation And Maritime Delimitation
Authors: Lando Massimo 
Published: March 2023

This brief contribution contains some reflections on the relevance of the “what about me?” question in proceedings on compensation and maritime delimitation. The focus is on disputes at the International Court of Justice (ICJ or Court). My argument is that, as things currently stand at the ICJ, the Court is ill-equipped to address the “what about me?” question and that, as a result, ICJ proceedings remain very much state-centric. This view likely is not surprising because the Court was conceived, since its origins in the 1920s, as an interstate judicial organ. Other dispute settlement institutions have developed since then to bring dispute settlement closer to individuals, such as regional human rights courts and arbitral tribunals in the investor-state context. However, this situation does not mean that the ICJ should not take into account individuals in deciding disputes submitted to its jurisdiction. What this situation does mean is that one would need to rethink some procedural aspects of ICJ dispute settlement, which I will discuss in relation to compensation, and parts of the ICJ's jurisprudence, which I will discuss in relation to maritime delimitation.
China's dream for chip supremacy: Seeing through the lens of panel display-related IC patents
Authors: Choung Eunji , Koo Min Gyo 
Published: March 2023

AbstractAs China has made it a top priority to enrich and upgrade its chip capabilities across the value chain, some international observers predict that China's semiconductor industry will eventually, if not immediately, surpass its foreign competitors. Others remain skeptical about its presumed tech supremacy for plausible but largely speculative reasons. Is the Chinese semiconductor industry a game-changer or a paper tiger? Is China's indigenous chip technology attractive to, and usable by, foreign technology? One way to look into these half-empty/half-full questions is to comparatively analyze chip patents granted by the US Patent and Trademark Office. The target domain of this study is integrated circuits (IC) technology, especially thin-film-transistor circuits, where China has recently registered a sharp growth in patent publications. Using the modified forward citation indices of panel display-related IC patents, this study examines whether and to what extent the quantitative growth in the Chinese semiconductor industry has been translated into a gravitational force to pull foreign industries within its sphere of influence. Estimation results of a zero-inflated negative binomial regression analysis show that a Chinese chip patent has a fewer expected modified forward citation index than a non-Chinese patent. These findings indicate that the technological gap between China and advanced countries will take longer to close despite China's accelerated campaign for chip supremacy. This study concludes, with some caveats, that China faces the dual challenge of achieving higher productivity and greater self-reliance, while having to survive in the escalating technological competition with other advanced countries.
Evidence for constraints on probing dynamics: A case study of adjectival concord
Authors: Jarrah Marwan , Abusalim Nimer , Alrashdan Imran 
Published: March 2023

AbstractBased on facts of adjectival concord in Standard Arabic, this article offers evidence that upward probing (i.e., the goal c-commands the probe) is permitted only if downward probing (i.e., where the probe c-commands the goal) does not result in valuing the probe's uninterpretable feature. Such a constraint on upward probing allows us to account for several intriguing observations in Arabic grammar, including the fact that an adjective can agree in number and gender with one nominal, but in definiteness with another nominal. Hence, on the one hand, this article lends support to Agree proposals according to which absence of a match in the c-command domain of an unvalued feature (uF) is not fatal to the derivation. On the other hand, it speaks against Agree proposals that do not license downward probing or view it as parasitic on upward probing.
Extremal Gromov-Witten invariants of the Hilbert scheme of Points
Authors: Hu Jianxun , Qin Zhenbo 
Published: March 2023

AbstractWe determine all the extremal Gromov-Witten invariants of the Hilbert scheme of$3$points on a smooth projective complex surface. Our result for the genus-$1$case verifies a conjecture that we propose for the genus-$1$extremal Gromov-Witten invariant of the Hilbert scheme ofnpoints withnbeing arbitrary. The main ideas in the proofs are to use geometric arguments involving the cosection localization theory of Kiem and J. Li [17, 23], algebraic manipulations related to the Heisenberg operators of Grojnowski [13] and Nakajima [34], and the virtual localization formulas of Gromov-Witten theory [12, 20, 30].
Making wine, selling grapes, or delivering to a cooperative? Determinants of grape allocation
Authors: Corsi Alessandro , Mazzarino Simonetta , Frontuto Vito 
Published: March 2023

AbstractA typical characteristic of the wine supply chain in the Old World is the significant share of cooperatives in wine-making that coexists with investor-owned firms and on-farm wine-makers. This paper analyzes the determinants of whether grape growers deliver their grapes to a cooperative winery of which they are members, sell their grapes to outside wineries, or make their own wine on their farm. Our analysis is based on data from a typical wine-producing area in Northern Italy. The explanatory variables comprise the potential prices linked to the different grape allocations and various farmer and farm characteristics. The high share of farmers delivering their grapes to cooperatives can, to a large extent, be explained by their higher price relative to one of the spot markets. On-farm wine-making is favored by larger farms and more educated farmers.
Overcoming death anxiety: a phase I trial of an online CBT program in a clinical sample
Authors: Menzies Rachel E. , Julien Alexandra , Sharpe Louise , Menzies Ross G. , Helgadóttir Fjóla Dögg , Dar-Nimrod Ilan 
Published: March 2023

AbstractBackground:Growing research indicates that death anxiety is implicated in many mental health conditions. This increasing evidence highlights a need for scalable, accessible and cost-effective psychological interventions to reduce death anxiety.Aims:The present study outlines the results of a phase I trial for one such treatment: Overcome Death Anxiety (ODA). ODA is the first CBT-based online intervention for fears of death, and is an individualised program requiring no therapist guidance.Method:A sample of 20 individuals with various mental health diagnoses commenced the ODA program. Death anxiety was assessed at baseline and at post-intervention. Depression, anxiety and stress were also measured.Results:In total, 50% (10/20) reached the end of the program and completed post-treatment questionnaires. Of these, 60% (6/10) showed a clinically reliable reduction in their overall death anxiety, and 90% (9/10) showed a reduction on at least one facet of death anxiety. There were no adverse events noted.Conclusions:ODA appears to be a safe and potentially effective treatment for death anxiety. The findings have provided initial evidence to support a randomised controlled trial using a larger sample, to further examine the efficacy of ODA.
Development, Validation, and Evidence of Measurement Invariance of a Shortened Measure of Trait Test Anxiety
Authors: Ober Teresa M. , Liu Cheng , Cheng Ying 
Published: March 2023

Abstract: We develop and validate a short self-report measure of test anxiety, the Trait Test Anxiety Inventory – Short (TTAI-S) following the Kane (2013) validation framework. Data were collected from three independent samples of young adults in the US ( N = 629; Mage = 22.25 years). Evidence was gathered to support three aspects of the validity argument (i.e., scoring, extrapolation, and generalization). Good internal consistency and confirmed structure of a single factor supported scoring inferences. Scalar measurement invariance between different samples (Internet vs. undergraduate students) and demographic subgroups (i.e., gender, race/ethnicity, and parental educational attainment) provided evidence for generalization inferences. Significant associations between the TTAI-S score and theoretically relevant (state test anxiety, performance expectation, and self-confidence in math) and weaker associations with less relevant constructs (enjoyment, motivation, and values in learning math) substantiated extrapolation inferences. Having established measurement invariance, we examined demographic differences and found that students historically underserved or underrepresented in STEM disciplines reported greater test anxiety than their counterparts. These findings support the validity of the TTAI-S, a concise measure that is easy to administer and easy to score. The TTAI-S may be used to further investigate trait test anxiety for a diverse population, particularly factors that may contribute to or mitigate group differences.