bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic Catheter-Related Venous Thromboembolism in Children: Data From the Italian Registry of Pediatric Thrombosis
Authors: Lasagni Donatella , Nosadini Margherita , Molinari Angelo Claudio , Saracco Paola , Pelizza Maria Federica , Piersigilli Fiammetta , Putti Maria Caterina , Gaffuri Marcella , Giordano Paola , Lorenzoni Giulia , Francavilla Andrea , Trapani Sandra , Luciani Matteo , Suppiej Agnese , Tufano Antonella , Tormene Daniela , Martinato Matteo , Gregori Dario , Sartori Stefano , Simioni Paolo ,   The Systemic Thromboses Working Group of the Italian Registry of Pediatric Thrombosis (RITI Registro Italiano Trombosi Infantili)
Published: January 2023

BackgroundCentral venous catheters (CVCs) represent one of the main risk factors for venous thrombotic events (VTEs) in children.MethodsWe studied the Italian Registry of Pediatric Thrombosis (RITI) with regard to systemic radiologically confirmed CVC-related VTEs (CVC-VTEs) occurred during 6.5 years in children aged 29 days to 18 years.ResultsA total of 78 CVC-VTEs were included, which occurred in 76 patients (40/76, 53% males). CVC-VTEs comprised 67 non-cardiac VTEs (86%) and 11 intracardiac thrombotic events (ICTEs) (14%); the median age at onset was 19 and 17 months, respectively. The most frequent reason for CVC insertion was supportive therapy. The catheters were placed percutaneously in 85% of cases (56/66) and surgically in the remaining 15% (10/66). Peripherally inserted central catheters (PICCs) were used in 47% (31/66) cases, partially implanted catheters in 42% (28/66), non-implantable catheters in 7% (5/66), and totally implanted catheters (Port) in 2% (1/66). CVC-VTEs were symptomatic in 77% of cases (60/78), while in the remaining 23%, they were incidentally detected on the imaging performed for the underlying condition. The median time between CVC insertion and the onset of symptoms was 10 days in non-cardiac VTEs and 39 days in ICTEs. Doppler ultrasound was the diagnostic technique most frequently used. The venous compartment most frequently affected was the veins of the lower extremities (52%, 43/73). Anti-thrombotic treatment was administered in 96% of CVC-VTEs (75/78). About 2.6% (2/76) of patients experienced a second thrombotic event. At discharge, post-thrombotic syndrome was reported in 13.5% (5/37) events with available data, CVC replacement in 10.8% (4/47), and ischemic necrosis with toe finger amputation in 2.7% (1/37). Three patients died due to an underlying condition; no CVC-VTE-related deaths were reported.ConclusionsWe have carried out a registry-based study on CVC-VTEs in the children in Italy, providing the data that may help improve the detection and management of this CVC-related complication.
Mechanism of crocin I on ANIT-induced intrahepatic cholestasis by combined metabolomics and transcriptomics
Authors: Song Dandan , Zhu Pei , Dong Yankai , Wang Mengchao , Zhao Anna , Xia Hongdong , Chen Yunting , Zhou Qingguang , Xiang Lun , Zhang Junyi , Luo Guangming , Luo Yangjing 
Published: January 2023

Background: Intrahepatic cholestasis (IC) is a disorder of bile production, secretion, and excretion with various causes. Crocin I (CR) is effective in the treatment of IC, but its underlying mechanisms need to be further explored. We aimed to reveal the therapeutic mechanism of crocin I for IC by combining an integrated strategy of metabolomics and transcriptomics.Methods: The hepatoprotective effect of CR against cholestasis liver injury induced by α-naphthylisothiocyanate (ANIT) was evaluated in rats. The serum biochemical indices, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acid (TBA), total bilirubin (TBIL), direct bilirubin (DBIL), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β), as well as the liver oxidative stress indexes and the pathological characteristics of the liver were analyzed. In addition, we also performed a serum metabolomics study using UPLC-Q Exactive HF-X technology to investigate the effect of CR on the serum of rats with ANIT-induced IC and screened potential biomarkers. The enrichment analysis of differential expressed genes (DEGs) was performed by transcriptomics. Finally, the regulatory targets of CR on potential biomarkers were obtained by combined analysis, and the relevant key targets were verified by western blotting.Results: CR improved serum and liver homogenate indexes and alleviated liver histological injury. Compared with ANIT group, the CR group had 76 differential metabolites, and 10 metabolic pathways were enriched. There were 473 DEGs significantly changed after CR treatment, most of which were enriched in the retinol metabolism, calcium signaling pathway, PPAR signaling pathway, circadian rhythm, chemokine signaling pathway, arachidonic acid metabolism, bile secretion, primary bile acid biosynthesis, and other pathways. By constructing the “compound-reaction-enzyme-gene” interaction network, three potential key-target regulation biomarkers were obtained, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), ATP-binding cassette transporter G5 (ABCG5), and sulfotransferase2A1(SULT2A1), which were further verified by western blotting. Compared with the ANIT group, the CR group significantly increased the expression of ABCG5 and SULT2A1, and the expression of HMGCR significantly decreased.Conclusion: Combined metabolomic and transcriptomic analyses show that CR has a therapeutic effect on IC through regulation of the biosynthesis of bile acids and bilirubin in the bile secretion pathway and regulation of the expression of HMGCR, ABCG5, and SULT2A1.
Experimental comparison of Yb/Al/Ce and Yb/Al/P co-doped fibers on the suppression of transverse mode instability
Authors: Zhang Zhilun , Luo Yonghui , Xing Yingbin , Li Haiqing , Peng Jinggang , Dai Nengli , Li Jinyan 
Published: January 2023

We presented an experimental comparison of the core-composition difference on the suppression of the photodarkening and transverse mode instability effects. Two core-composition fibers, entailing Yb/Al/Ce and Yb/Al/P co-doped fibers, were fabricated by MCVD process combined with solution doping technique. The parameters of two fibers were almost the same. The PD-induced loss at equilibrium was 3.94 dB/m at 702 nm in Yb/Al/Ce fiber, while it was 0.99 dB/m in Yb/Al/P fiber. To obtain a deeper understanding of the impact of PD on laser performance, a bidirectional pumping fiber amplifier was constructed. Compared with Yb/Al/Ce co-doped fiber, the TMI thresholds of Yb/Al/P co-doped fiber were enhanced in co-pumped and counter-pumped schemes. Meanwhile, the slope efficiency in bidirectional scheme was promoted by 4%. Moreover, the transmittance at 638 nm confirmed the superior PD resistance of Yb/Al/P co-doped fiber. These experimental results pave the way for the further development of high-power fiber lasers.
A study on the relationship between mindfulness and work performance of web editors: Based on the chain mediating effect of workplace spirituality and digital competencies
Authors: He Jiazi , Li Xinwei , Wang Huiyi , Xu Zhiwu 
Published: January 2023

IntroductionBased on the job demands-resources model, this study aims to explore the relationship between mindfulness in web editors, work performance, workplace spirituality, and digital competencies.MethodsOnline data from the Tencent Questionnaire Platform was used to examine the proposed research model. We distributed questionnaires to new media companies, and a total of 431 valid questionnaires were collected.Results and DiscussionThe results suggested that mindfulness in web editors can improve workplace spirituality, digital competencies, and work performance. In addition, workplace spirituality was found to act as a mediator between mindfulness and work performance. And, digital competencies did not play a mediating role between mindfulness and work performance, but workplace spirituality and digital competencies played a chain mediating role between mindfulness and work performance. The study explained the internal impact mechanism of mindfulness on work performance in web editors, and proposed methods to improve mindfulness, revealing the chain mediating role of workplace spirituality and digital competencies in the impact of mindfulness on work performance, which might provide new insights into existing research. It can provide a reference for new media companies to manage the team of web editors and improve the work performance of web editors.
Neurocognitive function and associations with mental health in adults born preterm with very low birthweight or small for gestational age at term
Authors: Weider Siri , Lærum Astrid M. W. , Evensen Kari Anne I. , Reitan Solveig Klæbo , Lydersen Stian , Brubakk Ann Mari , Skranes Jon , Indredavik Marit S. 
Published: January 2023

ObjectivesTo assess neurocognitive function in adults born with low birthweight compared with controls and to explore associations between neurocognitive function and psychopathology in these groups.MethodsIn this prospective cohort study, one group born preterm with very low birthweight (VLBW: birthweight &lt;1,500 g, n = 53), one group born small for gestational age at term (SGA: birthweight &lt;10th percentile, n = 63) and one term-born control group (birthweight ≥10th percentile, n = 81) were assessed with neurocognitive tests, diagnostic interviews, and self-report questionnaires at 26 years of age.ResultsThe VLBW group scored significantly below the control group on several neurocognitive measures, including IQ measures, psychomotor speed, verbal fluency, aspects of visual learning and memory, attention, social cognition, working memory and fine motor speed. The SGA group consistently scored at an intermediate level between the VLBW and the control group and had significantly lower scores than controls on Performance IQ and psychomotor speed, including switching. In the VLBW group, associations were found between lower spatial working memory and the presence of anxiety disorders, internalizing and attention problems, and autistic traits. Furthermore, lower Full scale IQ was associated with attention problems when adjusting for sex and parental socioeconomic status.ConclusionAdults born preterm with VLBW or born term SGA displayed neurocognitive difficulties. Spatial working memory was associated with difficulties with attention, anxiety, and social function of VLBW adults. The finding and its clinical applicability should be further explored.
What factors determine brand communication? A hybrid brand communication model from utilitarian and hedonic perspectives
Authors: Fang Lingzhi Brian , Liu Mingzhen , Tang Liu 
Published: January 2023

IntroductionWith the advancement of new media, brand communication has been taken into consideration by lots of firms. Apparently, customer affection plays a significant role in brand communications, though few studies have determined how the twofold of information function works in this communication mechanism. Based on this research gap and practical background, this paper proposes a hybrid model of communication comprising the utilitarian and hedonic aspects.MethodsFor this study, 575 questionnaires were collected, followed by the structural equation modeling of the derived data to test the research model.ResultsThe results of statistical analysis show that the brand communication can be improved in terms of both utilitarian and hedonic aspects. Moreover, psychological contract and customer engagement play a chain mediation role in this mechanism.DiscussionThese findings contribute to the research of brand communication mechanism in digital era. Likewise, the findings offers several practical implications to the brand management.
The wellbeing of adolescents and the role of greenness: A cross-sectional study among Italian students
Authors: Scaioli Giacomo , Squillacioti Giulia , Bersia Michela , Bellisario Valeria , Borraccino Alberto , Bono Roberto , Dalmasso Paola , Lemma Patrizia 
Published: January 2023

IntroductionAdolescence is a critical period of life, and the level of wellbeing acquired during this stage might have an influence on health status in adulthood. The wellbeing of adolescents is associated with both biological and environmental determinants. To date, few studies have evaluated the effect of exposure to urban green spaces (i.e., greenness) on adolescents' wellbeing. Therefore, the aim of this study is to assess the association between exposure to greenness and the wellbeing of adolescents, accounting for the level of urbanization surrounding schools.MethodsIn the frame of the 2018 Italian Health Behaviour in School-aged Children (HBSC), we analyzed cross-sectional data from the Piedmont Region. Exposure to greenness was quantified by the Normalized Difference Vegetation Index (NDVI). Schools were geocoded, and a fixed buffer (radius 1,500 m) centered on each school was then built to enable average NDVI calculations. Adolescents' wellbeing was assessed by self-reported psychological, somatic, and psychosomatic health complaints as follows. Respondents were asked how often, in the last 6 months, they had experienced: (a) headache, (b) stomachache, (c) backache, (d) dizziness, (e) feeling low, (f) irritability or bad temper, (g) feeling nervous, and (h) difficulties getting to sleep using the HBSC Symptom Checklist (HBSC-SCL), an eight-item tool. Multivariable, multilevel logistic regression models tested the association between exposure to NDVI and psychosomatic, somatic, and psychological health complaints, one at a time, using schools as a random intercept.ResultsIn total, 2065 subjects (47.6% girls) aged 11 (48.4%) and 13 (51.6%) years were involved. Greenness was found to be inversely associated with reported psychosomatic (OR 0.72, 95% CI: 0.53–0.98) and psychological health complaints (OR 0.67, 95% CI: 0.49–0.92) in boys only, adjusting for age, urbanization level, and socioeconomic status, and stratifying by gender.DiscussionOur results support the implementation of future policies for urban environmental design supporting the increase of green spaces, as suggested by the United Nations Sustainable Development Goals. Further studies are needed to confirm our findings.
Computational design of custom therapeutic cells to correct failing human cardiomyocytes
Authors: Tieu Andrew , Phillips Katherine G. , Costa Kevin D. , Mayourian Joshua 
Published: January 2023

Background: Myocardial delivery of non-excitable cells—namely human mesenchymal stem cells (hMSCs) and c-kit+ cardiac interstitial cells (hCICs)—remains a promising approach for treating the failing heart. Recent empirical studies attempt to improve such therapies by genetically engineering cells to express specific ion channels, or by creating hybrid cells with combined channel expression. This study uses a computational modeling approach to test the hypothesis that custom hypothetical cells can be rationally designed to restore a healthy phenotype when coupled to human heart failure (HF) cardiomyocytes.Methods: Candidate custom cells were simulated with a combination of ion channels from non-excitable cells and healthy human cardiomyocytes (hCMs). Using a genetic algorithm-based optimization approach, candidate cells were accepted if a root mean square error (RMSE) of less than 50% relative to healthy hCM was achieved for both action potential and calcium transient waveforms for the cell-treated HF cardiomyocyte, normalized to the untreated HF cardiomyocyte.Results: Custom cells expressing only non-excitable ion channels were inadequate to restore a healthy cardiac phenotype when coupled to either fibrotic or non-fibrotic HF cardiomyocytes. In contrast, custom cells also expressing cardiac ion channels led to acceptable restoration of a healthy cardiomyocyte phenotype when coupled to fibrotic, but not non-fibrotic, HF cardiomyocytes. Incorporating the cardiomyocyte inward rectifier K+ channel was critical to accomplishing this phenotypic rescue while also improving single-cell action potential metrics associated with arrhythmias, namely resting membrane potential and action potential duration. The computational approach also provided insight into the rescue mechanisms, whereby heterocellular coupling enhanced cardiomyocyte L-type calcium current and promoted calcium-induced calcium release. Finally, as a therapeutically translatable strategy, we simulated delivery of hMSCs and hCICs genetically engineered to express the cardiomyocyte inward rectifier K+ channel, which decreased action potential and calcium transient RMSEs by at least 24% relative to control hMSCs and hCICs, with more favorable single-cell arrhythmia metrics.Conclusion: Computational modeling facilitates exploration of customizable engineered cell therapies. Optimized cells expressing cardiac ion channels restored healthy action potential and calcium handling phenotypes in fibrotic HF cardiomyocytes and improved single-cell arrhythmia metrics, warranting further experimental validation studies of the proposed custom therapeutic cells.
Encuiramientos
Authors: Del Valle Lattanzio Camilo 
Published: January 2023

El problema que ocupa las reflexiones del siguiente texto es sobre la dificultad de la descripción del sustantivo cuir. Apoyándose en distintos textos, el presente ensayo postula el entendimiento de lo cuir como verbo, es decir encuiramiento. En este segundo sentido, lo cuir viene a ser proceso no terminado, crítica placentera que abre un espacio de futuridad en medio de una cultura condenada a repetir reactivamente el pasado. A partir de una selección de obras de la literatura latinoamericana se muestran diferentes ejemplos de trama cuir que dislocan el ordenamiento heteronormado, desacralizan lo establecido, develan lo inacabado y abren de este modo posibilidades de cambio en el lenguaje.
The Unpublished Manuscript of Aleksandr Mikhaylov's Article “On Designations and Denominations in Music Sheets by A. N. Scriabin”
Authors: Чигарёва Евгения Ивановна 
Published: January 2023

В статье рассказывается о неопубликованной рукописи, найденной в архиве А. В. Михайлова — филолога, искусствоведа, переводчика, оставившего заметный след в музыкальной науке. Он подробно анализирует вербальный слой «Поэмы экстаза» — от названия до ремарок. Исследователь разделяет в нотном тексте традиционные итальянские обозначения - более нейтральные, связанные с динамикой и темпом, и индивидуальные — французские, опирающиеся на философскую систему Скрябина. В тесной связи с музыкой Михайлов раскрывает смысл этих обозначений, выявляя тенденции, свойственные позднему творчеству композитора. При этом он делает обобщения, касающиеся скрябинской эпохи в целом, когда, по его словам, «достигает своего пика своеобразный экстатизм зрелой и поздней психологической культуры XIX века». А. В. Михайлов называет это время эпохой второй психологизации музыки.
The article describes an unpublished manu­script found in the archive of A. V. Mikhaylov, a philo­logist, art critic, and translator, who left a noticeable mark on the science about music. He analyzes in detail the verbal layer in the “Poem of Ecstasy” from the title to the stage directions. The researcher separates the traditional Italian designations in the musical text—more neutral, associated with dynamics and tempo, and individual—French, based on Scriabin’s philosophical system. In close connection with music, Mikhailov reveals the meaning of these designations, revealing the tendencies inherent in the composer’s later work. At the same time, he makes generalizations concerning the Scriabin era as a whole, when, in his words, “the peculiar ecstaticism of the mature and late psychological culture of the 19th century reaches its peak.” A. V. Mikhaylov calls this time the era of the second psychologization of music.
“The Beggar's Opera”: A Ballad Piece by Gay, Swift and Pope
Authors: Ильюшкина Вероника Алексеевна 
Published: January 2023

В статье представлена история «Оперы Нищего» как литературного произведения, написанного Джоном Гэем в сотрудничестве с Джонатаном Свифтом и Александром Поупом. Реконструируется история его создания и путь к сцене, обсуждается проблема авторства «Оперы Нищего» и ее жанровый предшественник, вводится термин «балладная пьеса» и дается его определение. Кроме того, в статье исследуются пародия и сатира как сущностные черты пьесы, определяется влияние на нее жанров плутовского романа и памфлета и указывается ряд подражаний «Опере Нищего», в том числе пьесы «Полли» и «Ахилл» Джона Гэя.
The article presents the history of “The Beggar’s Opera” as literary writing written by John Gay in collaboration with Jonathan Swift and Alexander Pope. The text reconstructs the history of its creation and the path to the stage, discusses the problem of the authorship of “The Beggar’s Opera” and its genre predecessor, introduces the term “ballad piece,” and gives its definition. In addition, the article examines parody and satire as the essential features of the play, determines the influence of the picaresque novel and pamphlet genres on it, and indicates several of imitations of “The Beggar’s Opera,” including the plays “Polly” and “Achilles” by John Gay.
TOPOLOGICAL MODELS OF THE STRUCTUREOF THE DIFFUSION LAYER OF MULTIPONENT BINDERS
Authors: С-А. Ю. Муртазаев, , М. Ш. Саламанова, , М.М-Я. Зайпуллаев, , П. А. Кокшев, 
Published: January 2023

В работе установлена топологическая модель многокомпонентных наполненных вяжущих систем с использованием минеральных порошков, дающая возможность управлять процессами структурообразования и регулировать конкретный спектр свойств. Модель формирования структуры на основе кремнеземистых минеральных порошков в сочетании с гидратной известью можно выделить как наиболее подходящую для описания модели структурообразования бесклинкерных композитов, с использованием тонкодисперсных минеральных порошков из вторичного и некондиционного сырья, активированных щелочными растворами натрия или калия. Образуемые новообразования в диффузионном межфазовом слое представлены гелем кремниевой кислоты, гидросиликатами натрия или калия, гидроалюмосиликатами и гидрогранатами натрия и кальция, кальцитом и являются аналогами природных довольно прочных и долговечных минералов, как щелочных и щелочноземельных цеолитов, слюды, гидрослюды.
The paper establishes a topological model of multicomponent components of binder systems using mineral powders, which makes it possible to control the process of structure formation and determine specific spectral properties. Structure structure model based on models of siliceous mineral powders in concentration with hydrated lime, which can be distinguished as the most suitable for describing the structure formation of clinker-free composites using finely dispersed mineral powders from secondary and substandard raw materials activated with alkaline solutions of sodium or potassium.The new formations formed in the diffusion interfacial layer are represented by silicic acid gel, sodium or potassium hydrosilicates, hydroaluminosilicates and sodium and calcium hydrogarnets, calcite and are analogues of natural rather strong and durable minerals, such as alkaline and alkaline earth zeolites, mica, hydromica.