bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive peptides in preterm human milk: Impact of maternal characteristics and their association to neonatal outcomes
Authors: Balcells‐Esponera Carla , Borràs‐Novell Cristina , López‐Abad Miriam , Cubells Serra Inmaculada , Basseda Puig Anna , Izquierdo Renau Montserrat , Herranz Barbero Ana , Iglesias‐Platas Isabel 
Published: August 2023

AbstractHuman milk adipokines in term babies seem partially determined by maternal factors and affect infant's development. We aimed to describe bioactive peptide concentration in very preterm human milk and associations to maternal characteristics and postnatal growth. Mothers delivering ≤32 weeks of gestation and their infant/s were recruited. At 4 weeks of lactation, an aliquot of 24‐h‐pooled milk was collected for exclusively breastfeeding dyads. Insulin, leptin, adiponectin, and milk fat globule epidermal growth factor‐8 (MFG‐E8) were measured by enzyme‐linked immunoabsorbent assay in skimmed milk. One hundred mothers (28.8 ± 2.3 weeks at delivery) provided a milk sample. Milk insulin was related to gestational age, pre‐pregnancy body mass index (BMI), and galactagogue treatment (final model: adjusted R2: 0.330, p < 0.0001; adjusted β coefficients: galactagogue treatment: 0.348, p 0.001; pre‐pregnancy BMI: 0.274, p 0.009; gestational age: −0.290, p 0.007). Adiponectin was higher in mothers with gestational diabetes (30.7 ± 6.5 vs. 24.8 ± 8 ng/mL, p 0.044). Leptin was associated with pre‐pregnancy BMI (Spearman's ρ: 0.648, p < 0.0001) and MFG‐E8 to presence of labor and multiple pregnancy (final linear regression model, R2: 0.073, p 0.028, adjusted β coefficients: presence of labor −0.229, p 0.050; twins: −0.192, p 0.099). Milk adiponectin was associated with a greater decrease in length z‐scores from birth to 28 days (Pearson's r: −0.225, p 0.032) and to discharge (Pearson's r: −0.290, p 0.003). Milk MFG‐E8 was lower in milk of mothers whose babies experienced late‐onset sepsis (13.3 ± 5.8 vs. 16.8 ± 6.3 μg/mL, p 0.023). Adipokines levels in preterm human milk are partially related to maternal metabolic status. Milk peptide concentration associates with early neonatal growth trajectories.
Lesion location and serum levels of homocysteine are associated with early‐onset post‐stroke depression in acute ischemic stroke
Authors: Zhou Hongxu , Wang Chenlong , Wang Wei , Li Hongyan , Hu Qun , Huang Ni , Huang Yining 
Published: August 2023

AbstractIntroductionIt is well known that post‐stroke depression (PSD) is a psychiatric complication after stroke which leads to worse functional outcome and poorer quality of life. Some risk factors including gender, stroke severity, lesion location, homocysteine (HCY), and so on are associated with PSD. This study aims to further explore the possible relationship between serum levels of HCY and early‐onset PSD and the predictive value of HCY combined with stroke characteristics for early‐onset PSD.MethodsTwo hundred forty‐five patients with acute ischemic stroke who met the criteria were included in this study from March 2015 to March 2017. PSD was diagnosed at 2 weeks after stroke. The severity of depressive symptoms was evaluated with the Hamilton depression scale 17 items (HAMD‐17), and patients with HAMD scores ≥7 were included in the PSD group. The demographic data, clinical characteristics, serum levels of HCY, and detailed radiological variables (e.g., lesion location and quantity of the brain infarct) were also examined.ResultsIn total, 97 (39.6%) patients of the 245 patients were diagnosed with depression. The univariate analyses suggested that patients in PSD group had a higher NIHSS score, modified Rankin Scale score, and HCY levels than patients in non‐PSD group (p < .001). The patients with PSD had higher proportion of multiple‐site acute infarcts and frontal lobe lesion (p < .05). In multivariate logistic regression analysis, NIHSS score at admission, serum levels of HCY, and multiple‐site lesions were independently related to early‐onset PSD. Based on receiver operating characteristic curves analysis, the combination of HCY, NIHSS scores, multiple‐site lesions, and lesion location revealed a highest area under the curve of 0.807 (95% confidence interval [CI]: 0.748–0.865, p < .001). Furthermore, there was a significantly increased risk of early‐onset PSD associated with serum levels of HCY ≥16.98 μmol/L (odds ratio [OR] = 10.976, 95% CI: 5.585–21.573, p < .001).ConclusionsOur study indicated that higher NIHSS score, elevated serum levels of HCY, and multiple‐site lesions may be independent risk factors of early‐onset PSD. The combination of HCY, NIHSS scores, multiple‐site lesions, and lesion location may provide greater predictive value than HCY alone for early‐onset PSD. Early intervention for elevated serum levels of HCY may be a potential target for the intervention and prevention of PSD.
Green consumption and sustainable development: The effects of perceived values and motivation types on green purchase intention
Authors: Ng Peggy M. L. , Cheung Cherry T. Y. , Lit Kam Kong , Wan Calvin , Choy Ellesmere T. K. 
Published: August 2023

AbstractDaily green products have gained growing awareness in recent years. Perceived values of consumers are crucial for companies to promote the formation of holistic value of green products to consumers. In addition, understanding different motivation types of consumers to adopt green purchase behavior is critical. To answer the research call to better conceptualize green purchase intention, this study aims to investigate how consumers' perceived values influence different motivation types, and in turn, affect their green purchase behavioral intention. An extended research model by integrating customer value theory (CVT) and self‐determination theory (SDT) is developed to explain green purchase behavioral intention. Three hundred and five participants were recruited, and the findings were analyzed using partial least square structural equation modelling (PLS‐SEM). Results suggested that the three perceived values (i.e., emotional value, functional value, and relational value) significantly predict perceived green product value, while perceived green product value predicts four types of regulations (i.e., external regulation, introjected regulation, identified regulation, and integrated regulation). Results also showed that autonomous motivation (i.e., identified regulation and integrated regulation) significantly predicts green purchase intention. These findings provide theoretical implications to SDT and customer value theory in the field of green business strategy management and practical implications to green businesses and governments.
The expression and function of long noncoding RNAs in hepatocellular carcinoma
Authors: Du Jingli , Su Yue , Gao Jianzhi , Tai Yanhong 
Published: August 2023

AbstractWith the deepening of the genome project study, attention on noncoding RNAs is increasing. Long noncoding RNAs (lncRNAs) have become a new research hotspot. A growing number of studies have revealed that lncRNAs are involved in tumorigenesis and tumor suppressor pathways. Aberrant expressions of lncRNAs have been found in a variety of human tumors including hepatocellular carcinoma (HCC). In this review, we provide a brief introduction to lncRNA and highlight recent research on the functions and clinical significance of lncRNAs in HCC.
Systemic therapy for Asian patients with advanced BRAF V600‐mutant melanoma in a real‐world setting: A multi‐center retrospective study in Japan (B‐CHECK‐RWD study)
Authors: Namikawa Kenjiro , Ito Takamichi , Yoshikawa Shusuke , Yoshino Koji , Kiniwa Yukiko , Ohe Shuichi , Isei Taiki , Takenouchi Tatsuya , Kato Hiroshi , Mizuhashi Satoru , Fukushima Satoshi , Yamamoto Yosuke , Inozume Takashi , Fujisawa Yasuhiro , Yamasaki Osamu , Nakamura Yasuhiro , Asai Jun , Maekawa Takeo , Funakoshi Takeru , Matsushita Shigeto , Nakano Eiji , Oashi Kohei , Kato Junji , Uhara Hisashi , Miyagawa Takuya , Uchi Hiroshi , Hatta Naohito , Tsutsui Keita , Maeda Taku , Matsuya Taisuke , Yanagisawa Hiroto , Muto Ikko , Okumura Mao , Ogata Dai , Yamazaki Naoya 
Published: August 2023

AbstractBackgroundAnti‐PD‐1‐based immunotherapy is considered a preferred first‐line treatment for advanced BRAF V600‐mutant melanoma. However, a recent international multi‐center study suggested that the efficacy of immunotherapy is poorer in Asian patients in the non‐acral cutaneous subtype. We hypothesized that the optimal first‐line treatment for Asian patients may be different.MethodsWe retrospectively collected data of Asian patients with advanced BRAF V600‐mutant melanoma treated with first‐line BRAF/MEK inhibitors (BRAF/MEKi), anti‐PD‐1 monotherapy (Anti‐PD‐1), and nivolumab plus ipilimumab (PD‐1/CTLA‐4) between 2016 and 2021 from 28 institutions in Japan.ResultsWe identified 336 patients treated with BRAF/MEKi (n = 236), Anti‐PD‐1 (n = 64) and PD‐1/CTLA‐4 (n = 36). The median follow‐up duration was 19.9 months for all patients and 28.6 months for the 184 pa tients who were alive at their last follow‐up. For patients treated with BRAF/MEKi, anti‐PD‐1, PD‐1/CTLA‐4, the median ages at baseline were 62, 62, and 53 years (p = 0.03); objective response rates were 69%, 27%, and 28% (p < 0.001); median progression‐free survival (PFS) was 14.7, 5.4, and 5.8 months (p = 0.003), and median overall survival (OS) was 34.6, 37.0 months, and not reached, respectively (p = 0.535). In multivariable analysis, hazard ratios (HRs) for PFS of Anti‐PD‐1 and PD‐1/CTLA‐4 compared with BRAF/MEKi were 2.30 (p < 0.001) and 1.38 (p = 0.147), and for OS, HRs were 1.37 (p = 0.111) and 0.56 (p = 0.075), respectively. In propensity‐score matching, BRAF/MEKi showed a tendency for longer PFS and equivalent OS with PD‐1/CTLA‐4 (HRs for PD‐1/CTLA‐4 were 1.78 [p = 0.149]) and 1.03 [p = 0.953], respectively). For patients who received second‐line treatment, BRAF/MEKi followed by PD‐1/CTLA‐4 showed poor survival outcomes.ConclusionsThe superiority of PD‐1/CTLA‐4 over BRAF/MEKi appears modest in Asian patients. First‐line BRAF/MEKi remains feasible, but it is difficult to salvage at progression. Ethnicity should be considered when selecting systemic therapies until personalized biomarkers are available in daily practice. Further studies are needed to establish the optimal treatment sequence for Asian patients.
The digital divide: Racial disparities in adoption and utilization of health information technology among patients with lymphoid cancers
Authors: Ailawadhi Sikander , Ailawadhi Meghna , Dutta Navnita , Parrondo Ricardo D. , Roy Vivek , Sher Taimur , Baksh Mizba , Rasheed Ahsan , Das Saurav , Fernandez Andre J. , Paulus Aneel , Chanan‐Khan Asher A. 
Published: August 2023

AbstractIntroductionHealth information technology (HIT) has the potential to improve healthcare delivery and engagement. Studying racial‐ethnic disparities in HIT engagement will help understand and overcome challenges to healthcare utilization.MethodsWe undertook a patient‐reported survey among patients with lymphoid malignancies at two campuses of Mayo Clinic, Florida to explore HIT‐related disparities. Variables between Whites and non‐Whites, and non‐Whites from the two campuses were compared.ResultsThe survey was completed by 1004 respondents, with 71% whites, 27% non‐Whites (race‐ethnicity not reported by 2%). Non‐Whites included 30% responders at the main campus and 64% at an inner‐city campus. Whites were significantly older and had higher education, while non‐Whites had lesser access to a computer. Only 51% of non‐Whites were registered to use electronic medical records (EMR) as compared to 72% Whites (p < 0.001) and significantly lesser number of non‐Whites even knew that EMR existed (81% vs. 92%, p < 0.001). Encouragingly, a higher number of non‐Whites wanted to engage in EMR. Non‐Whites from the main campus were older, more educated and had more access to a computer as compared to those from the inner‐city campus. Similar disparate factors were noted among minorities from the two campuses, suggesting impact of socioeconomic backgrounds on EMR usage among non‐Whites. Linguistic barriers were more striking among inner‐city campus non‐Whites.ConclusionsNon‐Whites continue to struggle with suboptimal utilization of the healthcare system and barriers related to integration in HIT, including disparities representing socioeconomic differences. Efforts need to be made at several levels to help racial‐ethnic minorities overcome awareness, access, and linguistic barriers to HIT utilization.
Putative role of non‐invasive vagus nerve stimulation in cancer pathology and immunotherapy: Can this be a hidden treasure, especially for the elderly?
Authors: Abdullahi Auwal , Wong Thomson W. L. , Ng Shamay S. M. 
Published: August 2023

AbstractCancer is globally a disease of significant public health concern owing to its prevalence, and association with morbidity and mortality. Thus, cost‐effective treatments for cancer are important to help reduce its significant morbidity and mortality. However, the current therapeutic options for cancer such as chemotherapy, radiotherapy, and surgery may produce serious adverse events such as nausea, vomiting, fatigue, and peripheral neuropathy, especially in the long term. In addition, these therapeutic options may not be well tolerated by the elderly especially those who are frail. The current article is aimed at discussing an alternative therapeutic option, non‐invasive vagus nerve stimulation (VNS), and the roles it plays in cancer pathology and immunotherapy. The VNS does this by reducing oxidative stress via silent information regulator 1 (SIRT1); inhibiting inflammation via both hypothalamic–pituitary–axis (HPA) and the release of corticosteroid from the adrenal gland, and cholinergic anti‐inflammatory pathway (CAP), and increasing vagal activity which helps in the regulation of cell proliferation, differentiation, apoptosis, and metabolism, and increase chance of survival. Furthermore, it helps with reducing complications due to cancer or its treatments such as postoperative ileus and severity of peripheral neuropathy induced by chemotherapy, and improves cancer‐related fatigue, lymphopenia, and quality of life. These suggest that the importance of non‐invasive VNS in cancer pathology and immunotherapy cannot be overemphasized. Therefore, considering the safety of non‐invasive VNS and its cost‐effectiveness, it is a therapeutic option worth trying for these patients, especially in combination with other therapies.
Anti‐inflammatory effect of polydeoxyribonucleotides (PDRN) extracted from red alga (Porphyra sp.) (Ps‐PDRN) in RAW 264.7 macrophages stimulated with Escherichia coli lipopolysaccharides: A comparative study with commercial PDRN
Authors: Kim Tae‐Hee , Heo Seong‐Yeong , Han Ji Sung , Jung Won‐Kyo 
Published: August 2023

AbstractPolydeoxyribonucleotide (PDRN) is a DNA‐derived drug extracted from the sperm cells of Oncorhynchus mykiss or O. keta. PDRN exhibits wound healing and anti‐inflammatory activities by activating adenosine A2A receptor and salvage pathways. However, commercial PDRN products (e.g., Placentex, Rejuvenex, and HiDr) have limitations as they are exclusively extracted O. mykiss and O. keta, which are expensive and can only be used as extraction sources during a specific period when their sperm cells are activated. Therefore, this study aimed to extract PDRN from Porphyra sp. (Ps‐PDRN) and investigate whether it has anti‐inflammatory activity through a comparative study with commercial product. The results indicated that Ps‐PDRN had an anti‐inflammatory effect on Escherichia coli lipopolysaccharides (LPS)‐stimulated RAW 264.7 macrophages. It inhibited nitric oxide production and inducible nitric oxygen synthase protein expression by suppressing phosphorylation of p38 and ERK, without cytotoxicity. Furthermore, Ps‐PDRN promoted cell proliferation and collagen production in human dermal fibroblast. In conclusion, our study confirms that Ps‐PDRN exhibits both anti‐inflammatory and cell proliferative effects. These results indicated that Ps‐PDRN has the potential as a bioactive drug for tissue engineering.
Characteristics and treatments of patients with significantly elevated creatine kinase levels induced by seizures: Case report and literature review
Authors: Wang Kai , Yang Jinwei , Xu Wenhao , Wang Lei , Wang Yu 
Published: August 2023

Key Clinical MessageMotor signs accompanying seizures have been considered to result in overexertion of muscles and have the ability to cause elevated levels of serum creatine kinase (CK). There were no previous studies on the treatment of seizure‐induced elevated CK. We summarized the characteristics and treatments of six patients with significant elevation of CK after seizure onset. There were four males and two females, the age range was 16–68 years. The CK levels were greater than 5000 U/L in five of the six patients and the highest CK level was 39,300 U/L. All patients exhibited an estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m2. No patient developed renal failure or required continuous renal replacement therapy. We determined that serial assessment of CK, myoglobin, eGFR, and electrolytes should be performed in patients following seizures. Furthermore, fluid resuscitation, urine alkalization, and diuretic agents should be administrated when CK are significantly elevated after seizure onset. Serial assessment of CK levels after seizures should be performed, especially when the patient experiences electrolyte disorders. Fluid resuscitation, urine alkalization, and diuretic agents also should be administrated to patients when they exhibit a significantly elevated CK or myoglobin after seizures.
Variable CD18 expression in a 22‐year‐old female with leukocyte adhesion deficiency I: Clinical case and literature review
Authors: Bondarenko Anastasiia V. , Boyarchuk Oksana R. , Sakovich Inga S. , Polyakova Ekaterina A. , Migas Alexander A. , Kupchinskaya Aleksandra N. , Opalinska Aleksandra , Reich Adam , Volianska Liubov , Hilfanova Anna M. , Lapiy Fedir I. , Chernyshova Liudmyla I. , Volokha Alla P. , Zabara Dariia V. , Belevtsev Mikhail V. , Shman Tatsiana V. , Kukharenko Lyudmila V. , Goltsev Mikhail V. , Dubouskaya Tatsiana G. , Hancharou Andrei Y. , Ji Weizhen , Lakhani Saquib , Lucas Carrie L. , Aleinikova Olga V. , Sharapova Svetlana O. 
Published: August 2023

Key Clinical MessagePartial leukocyte adhesion deficiency type 1 (LAD‐1) deficiency is extremely rare condition with milder infectious manifestation and immune system imbalance leads to increased risks of autoinflammatory complications, such as pyoderma gangrenosum, that can be triggered by trauma or pregnancy. In patients with spice‐site ITGB2 variants, partial expression can occur due to different β2 integrin isophorms expression.AbstractLAD‐1, OMIM ID #116920 is a rare, autosomal recessive disorder that results from mutations in the ITGB2 gene that encodes the CD18 β2 integrin subunit. According to the CD18 expression, LAD‐1 is categorized as severe (<2%), moderate (2%–30%), or mild (>30%). Here, we describe a 22‐year‐old female, who presented with inflammatory skin disease and oral cavity, as well as respiratory tract infections during the first year of life. LAD‐1 was diagnosed at the age of 2 years by low expression of CD18 (1%). Whole‐exome sequencing identified homozygous c. 59‐10C>A variant in the ITGB2 gene. Despite severe phenotype, the patient survived to adulthood without hematopoietic stem cell transplantation and became pregnant at the age of 20 years, with pregnancy complicated by a pyoderma gangrenosum‐like lesion. During her life, CD18 expression increased from 1% to 9%; at 22 years of age, 5% of neutrophils and 9% of lymphocytes were CD18+. All CD18+‐lymphocytes were predominantly memory/effector cytotoxic T cells. However, revertant mosaicism was not being established suggesting that CD18 expression variability may be mediated by other mechanisms such as different β2 integrin isophorms expression.
Homogeneous Iron‐Catalysed Oxidation Of Non‐Activated Alkanes With Hydrogen Peroxide
Authors: Mao Shuxin , Verspeek Dennis , Wen Xiaodong , Yang Yong , Li Yong‐Wang , Junge Kathrin , Beller Matthias 
Published: August 2023

AbstractA novel synthetic protocol for the direct oxidation of alkanes, including cyclic and linear ones, to give ketones and alcohols using hydrogen peroxide as terminal oxidant under ambient conditions is presented. The active catalyst for this challenging transformation is conveniently generated by combination of simple Fe salts with N‐methyl bis(picolylamine) (Me‐bpa). Utilizing picolinic acid as additive leads to improved yields of ketones and alcohols (32‐57 %). The reaction can be conveniently scaled up to multi‐g scale.
Removal of Organochlorine Compounds from Coal Tar by Nucleophilic Substitution and Coalescence
Authors: Du Hengxing , Gao Zhongyang , Li Wangliang 
Published: August 2023

AbstractAn integrated process of phase transfer nucleophilic substitution and coalescence is proposed to upgrade coal tar by simultaneously removing organochlorine compounds (OOCs) and water. For the phase transfer catalysts (PTCs) and nucleophiles, polyethylene glycol 400 (PEG‐400) and triethanolamine (TEOA) were the most effective to remove OOCs from coal tar. The optimal parameters of the dichlorination process in terms of molar ratio of PEG‐400 and TEOA to OOCs, reaction temperature, reaction time, and stirring speed were determined. The chloride removal efficiency reached 80.66 % when glass fiber was used for oil‐water coalescence separation. A promising method for simulllltaneously removing chloride and water from coal tar is provided.
Photoreduction of Anthracenes Catalyzed by peri‐Xanthenoxanthene: a Scalable and Sustainable Birch‐Type Alternative
Authors: De Luca Cristian , Zanetti Davide , Battisti Tommaso , Ferreira Rúben R. , Lopez Sofia , McMillan Alexander H. , Lesher‐Pérez Sasha Cai , Maggini Laura , Bonifazi Davide 
Published: August 2023

AbstractThe typical Birch reduction transforms arenes into cyclohexa‐1,4‐dienes by using alkali metals, an alcohol as a proton source, and an amine as solvent. Capitalizing on the strong photoreductive properties of peri‐xanthenoxanthene (PXX), herein we report the photocatalyzed “Birch‐type” reduction of acenes by employing visible blue light irradiation at room temperature in the presence of air. Upon excitation at 405 or 460 nm in the presence of a mixture of N,N‐diisopropylethylamine (DIPEA) and trifluoromethanesulfonimide (HNTf2) in DMSO, PXX photocatalyzes the selective reduction of full‐carbon acene derivatives (24–75 %). Immobilization of PXX onto polydimethylsiloxane (PDMS) beads (PXX‐PDMS) allowed the use of the catalyst in heterogeneous batch reactions, giving 9‐phenyl‐9,10‐dihydroanthracene in high yield (68 %). The catalyst could easily be recovered and reused, with no notable drop in performance observed after five reaction cycles. Integration of the PXX‐PDMS beads into a microreactor enabled the reduction of acenes under continuous‐flow conditions, thereby validating the sustainability and scalability of this heterogeneous‐phase approach.