bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE THERMOLUMINESCENCE (TL) DOSE RESPONSE OF COMPOSITE PEAK 5 IN LIF:MG,TI (TLD-100): DEPENDENCE ON THE ORDER OF KINETICS
Authors: Nemirovsky Dimitry , Oster Leonid , Reshes Galina , Biderman Shlomo , Bokobza Yogev , Sterenberg Matan , Eliyahu Ilan , Shapiro Alexander , Herman Benny , Horowitz Yigal 
Published: March 2023

Abstract
A seeming contradiction in the prediction of the spatially correlated trapping center/luminescent center model applied to LiF:Mg,Ti has been the linear/supralinear behavior of the dose response of glow peak 5a. In the TC/LC model, the localised electron–hole recombination, giving rise to glow peak 5a, is expected to result in an extended region of linear dose response. Deconvolution of the glow curves based on first order kinetic peak shapes results, however, in a dose response of peak 5a, which closely resembles the linear/supralinear dose response of peak 5. It is demonstrated herein that when general-order kinetics peak shapes are used for peak 5a, the analysis can result in a linear dose response of glow peak 5a up to dose levels as high as 30 Gy, well beyond the 1-Gy onset of supralinearity of peak 5. The extended linearity suggests a resolution of the contradiction.
No Increased Detection of Nucleic Acids of CNS-related Viruses in the Brains of Patients with Schizophrenia, Bipolar Disorder, and Autism Spectrum Disorder
Authors: Min Shishi , Gandal Michael J , Kopp Richard F , Liu Chunyu , Chen Chao 
Published: March 2023

Abstract

Background and Hypothesis
Viral infections are increasingly recognized in the etiology of psychiatric disorders based on epidemiological and serological studies. Few studies have analyzed viruses directly within the brain and no comprehensive investigation of viral infection within diseased brains has been completed. This study aims to determine whether viral infection in brain tissues is a risk factor for 3 major psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder.

Study Design
This study directly evaluated the presence of viral DNA or RNA in 1569 brains of patients and controls using whole-genome sequencing and RNA sequencing data with 4 independent cohorts. The PathSeq tool was used to identify known human viruses in the genome and transcriptome of patients and controls.

Study Results
A variety of DNA and RNA viruses related to the central nervous system were detected in the brains of patients with major psychiatric disorders, including viruses belonging to Herpesviridae, Polyomaviridae, Retroviridae, Flaviviridae, Parvoviridae, and Adenoviridae. However, no consistent significant differences were found between patients and controls in terms of types and amount of virus detected at both DNA and RNA levels.

Conclusions
The findings of this study do not suggest an association between viral infection in postmortem brains and major psychiatric disorders.
Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling
Authors: Yin Wenzhen , Sun Lijun , Liang Yuan , Luo Chao , Feng Tiange , Zhang Yunhua , Zhang Weizhen , Yin Yue 
Published: March 2023

AbstractThe metabolic benefits of intermittent fasting (IF) have been well recognized. However, limited studies have examined the relationship between long‐term maternal IF before pregnancy and offspring health. In this study, a C57BL/6J mouse model of long‐term IF before pregnancy was established: 4‐week‐old female mice were subjected to alternate‐day fasting for 12 weeks and resumed normal diet after mating. Female mice in the control group were fed ad libitum. Offspring mice were weaned at 6 weeks of age and fed a normal chow diet or a 60% high‐fat diet. The effects of long‐term pre‐pregnancy IF on offspring metabolism and its underlying mechanism were examined. We found that neonatal IF offspring weighted significantly less relevant to control mice. This difference gradually disappeared as a result of catch‐up growth. In the IF offspring, adipose tissue mass was significantly increased. This alteration was associated with a considerable deterioration in glucose tolerance. No significant difference in food intake was observed. Further, lipid deposition as well as triglyceride contents in the liver were greatly increased. Maternal IF significantly decreased levels of DNA methyltransferase in the liver of offspring. DNA methylation modifications of molecules associated with the mTORC1 signaling pathway were significantly altered, leading to the significant inhibition of mTORC1 signaling. Overexpression of S6K1 activated hepatic mTORC1 signaling and reversed the metabolic dysfunction in IF offspring. In conclusion, long‐term pre‐pregnancy IF increases hepatic steatosis and adiposity, as well as impairs glucose metabolism in adult offspring. This occurs through DNA methylation‐dependent suppression of hepatic mTORC1 signaling activity.
Aspartate and Acetate Fuel Gastrointestinal Stromal Tumors Beyond the Warburg Effect
Authors: Lai Ying-Chieh , Lin Gigin , Ho Kung-Chu , Lu Kuan-Ying , Tsai Cheng-Kun , Hung Cheng-Yu , Yeh Ta-Sen 
Published: March 2023

Background:
Metabolic reprogramming is closely linked to the tumorigenesis and drug resistance of gastrointestinal stromal tumors (GISTs). Mapping the metabolic orbit of GISTs is a prerequisite if intervention against the metabolic vulnerability of refractory GISTs is desirable.

Methods:
A total of 43 patients with treatment-naïve GISTs who had undergone surgical resections were enrolled, on whom a metabolomics profile detected from surgical specimens was constructed based on the 1H-nuclear magnetic resonance (NMR) platform. The mRNA and protein levels of GLUT1, HK2, ACSS2, and FASN were assayed. Dual-tracer 18F-FDG/11C-acetate PET imaging was introduced before surgery in 15 patients.

Results:

1H-NMR-based metabolomics revealed that GISTs were characterized by upregulation of glutamate, ascorbate, aspartate and glycine and downregulation of choline, creatine, glucose and glycerol. Bioinformatics analysis showed that the TCA cycle and alanine, aspartate, and glutamate metabolism were the two leading pathways. High- and nonhigh-risk (including intermediate-, low-, and very low-risk) GISTs preferentially displayed upregulation of HK2 and ACSS2, respectively, echoed by in vivo imaging that high- and nonhigh-risk GISTs preferentially exhibited higher uptake of 18F-FDG and 11C-acetate, respectively, while 18F-FDG and 11C-acetate were complementary to each other. Nuclear ACSS2 was exclusively identified in high-risk GISTs.

Conclusion:
We describe a metabolic landscape of GISTs that read aspartate as a de facto “oncometabolite,” which was replenished via the TCA cycle and alanine, aspartate, and glutamate metabolism. Glycolysis and ACSS2-mediated acetate metabolism competed and complemented fatty acid synthesis, although glycolysis remained an aggressive phenotype.
Development of the Illinois Surgical Quality Improvement Collaborative (ISQIC)
Authors: Bilimoria Karl Y. , McGee Michael F. , Williams Mark V. , Johnson Julie K. , Halverson Amy L. , O’Leary Kevin J. , Farrell Paula , Thomas Juliana , Love Remi , Kreutzer Lindsey , Dahlke Allison R. , D’Orazio Brianna , Reinhart Steven , Dienes Katelyn , Schumacher Mark , Shan Ying , Quinn Christopher , Prachand Vivek N. , Sullivan Susan , Cradock Kimberly A. , Boyd Kelsi , Hopkinson William , Fairman Colleen , Odell David , Stulberg Jonah J. , Barnard Cindy , Holl Jane , Merkow Ryan P. , Yang Anthony D. ,   on behalf of the Illinois Surgical Quality Improvement Collaborative
Published: March 2023

Introduction:
In 2014, 56 Illinois hospitals came together to form a unique learning collaborative, the Illinois Surgical Quality Improvement Collaborative (ISQIC). Our objectives are to provide an overview of the first 3 years of ISQIC focused on (1) how the collaborative was formed and funded, (2) the 21 strategies implemented to support quality improvement (QI), (3) collaborative sustainment, and (4) how the collaborative acts as a platform for innovative QI research.

Methods:
ISQIC includes 21 components to facilitate QI that target the hospital, the surgical QI team, and the perioperative microsystem. The components were developed from available evidence, a detailed needs assessment of the hospitals, reviewing experiences from prior surgical and nonsurgical QI Collaboratives, and interviews with QI experts. The components comprise 5 domains: guided implementation (eg, mentors, coaches, statewide QI projects), education (eg, process improvement [PI] curriculum), hospital- and surgeon-level comparative performance reports (eg, process, outcomes, costs), networking (eg, forums to share QI experiences and best practices), and funding (eg, for the overall program, pilot grants, and bonus payments for improvement).

Results:
Through implementation of the 21 novel ISQIC components, hospitals were equipped to use their data to successfully implement QI initiatives and improve care. Formal (QI/PI) training, mentoring, and coaching were undertaken by the hospitals as they worked to implement solutions. Hospitals received funding for the program and were able to work together on statewide quality initiatives. Lessons learned at 1 hospital were shared with all participating hospitals through conferences, webinars, and toolkits to facilitate learning from each other with a common goal of making care better and safer for the surgical patient in Illinois. Over the first 3 years, surgical outcomes improved in Illinois.

Discussion:
The first 3 years of ISQIC improved care for surgical patients across Illinois and allowed hospitals to see the value of participating in a surgical QI learning collaborative without having to make the initial financial investment themselves. Given the strong support and buy-in from the hospitals, ISQIC has continued beyond the initial 3 years and continues to support QI across Illinois hospitals.
Surgeon Accuracy in Prediction of Stability of Posterior Wall Acetabular Fractures. A Survey of Orthopaedic Trauma Surgeons
Authors: Vatti Lohith , Schoenfeldt Theodore , Eikani Carlo , Dickens Brooke , Cohen Joseph , Dillman Daryl 
Published: March 2023

Objectives:
This study aims to investigate surgeon accuracy in prediction of the stability of posterior wall acetabular fractures by comparing “examination under anesthesia” findings to submitted estimations on the basis of radiograph and computed tomography (CT) imaging across a range of experience in orthopaedic surgeons and trainees.

Methods:
Records of patients who underwent examination under anesthesia after presenting with posterior wall acetabular fractures at 2 different institutions were pooled for data collection, totaling 50 cases. Radiographs, CT images, and information regarding the presence of a hip dislocation requiring procedural reduction were provided to participants for review. A survey was generated for submission of impressions of stability for each individual case and disseminated among orthopaedic trainees and surgeons in practice.

Results:
The submissions of 11 respondents were analyzed. Mean accuracy was calculated to be 0.70 (SD = 0.07). Sensitivity and specificity of respondents were 0.68 (SD = 0.11) and 0.71 (SD = 0.12), respectively. Positive predictive value and negative predictive value for respondents were 0.56 (SD = 0.09) and 0.82 (SD = 0.04), respectively. There was poor correlation of accuracy with years of experience with R2 calculated to be 0.0004 and poor agreement between observers with Kappa measurement of interobserver reliability of 0.46.

Conclusions:
Our study suggests that surgeons are unable to consistently differentiate between stable and unstable patterns on the basis of assessments based on x-ray and CT. Years of experience in training or practice was not found to be associated with improved accuracy of stability prediction.
Grading Systems of Lumbar Facet Joint Inflammatory Changes on Magnetic Resonance Imaging
Authors: Acosta José I. , Mandell Jacob C. , Ermann Joerg , Isaac Zacharia , Zampini Jay M. , DeFilipp Miriam , Gottreich Julia R. , Andrew Michael , Katz Jeffrey N. 
Published: March 2023

Study Design.
A scoping review.

Objective.
We aimed to identify and characterize grading systems of the inflammatory features of the lumbar facet joints (FJs) noted on magnetic resonance imaging and summarize their reliability.

Summary of Background Data.
Chronic low back pain is one of the most common causes of disability worldwide and is frequently accompanied by FJ osteoarthritis. Inflammatory changes in the lumbar FJs are commonly noted in imaging studies of patients with FJ osteoarthritis and low back pain. Several grading systems for these inflammatory changes have been developed. However, these grading system’s features and reliability have yet to be reviewed.

Materials and Methods.
We performed a literature search of studies reporting grading systems for FJ inflammatory changes published in English or Spanish between 1985 and 2022. We collected data on reported interreader reliability measures of each grading system. Finally, we compared the features of inflammation described by each system.

Results.
Six studies met the inclusion criteria and were used in our analysis. Features commonly graded in these systems are the hyperintensity signal noted within the FJ, bone marrow edema, and the extent of the soft-tissue edema surrounding the FJs. We found that the interreader reliability measures ranged from 0.56 to 0.96.

Conclusions.
Only 6 studies have reported methods for documenting inflammation in the FJs. Studies varied in the precise tissues and phenomena included in the grading systems. However, the systems were generally reliable. Future studies should document the reliability of these methods when independent investigators are not involved in developing the classification schemes. Further work might combine one or more of these measures to establish a standard and reliable grading system for inflammatory changes in the FJs, including signal intensity within the joint, bone marrow edema, and soft-tissue inflammation.
The Microbiome of Complicated Diverticulitis: An Imbalance of Sulfur-Metabolizing Bacteria
Authors: Portolese Austin C. , McMullen Brittney N. , Baker Samantha K. , Chen See Jeremy R. , Yochum Gregory S. , Koltun Walter A. , Lamendella Regina , Jeganathan Nimalan A. 
Published: March 2023

BACKGROUND:
The progression to acute diverticulitis from the relatively benign condition of colonic diverticulosis is not well characterized. A smaller subset may even develop complicated (perforated) diverticulitis resulting in sepsis and/or death. Characterizing the differences between recurrent, uncomplicated diverticulitis and the more virulent, complicated diverticulitis is necessary to guide clinical decision making. Alterations to the microbiome offer a possible explanation for local inflammation and the pathophysiology of diverticular disease.

OBJECTIVE:
To characterize the mucosal-associated microbiome in patients with recurrent uncomplicated diverticulitis and complicated (perforated) diverticulitis.

DESIGN:
Microbial DNA was extracted from full-thickness surgical specimens for 16S rRNA gene sequencing, targeting the V4 hypervariable region. Sequences were analyzed and a quantitative characterization based on taxonomic classification was performed.

SETTING:
A tertiary care academic medical center.

PATIENTS:
This study compared 48 patients with recurrent, uncomplicated diverticulitis and 35 patients with radiographically-confirmed perforated (complicated) diverticulitis. Tissues were harvested from surgical resection specimens to include both diseased regions as well as non-diseased (adjacent normal) regions.

MAIN OUTCOME MEASURES:
We assessed differences in relative abundance and taxonomic classification of mucosal-associated microbes in surgical resection specimens from diverticular disease.

RESULTS:
When analyzing the tissue of diverticular resection specimens, the complicated diseased segments demonstrated an increased abundance of sulfur-reducing and sulfur-oxidizing bacteria when compared to non-diseased, adjacent normal regions. When comparing diseased segments, tissues of complicated patients had a marked increase in sulfur-reducing microbes.

LIMITATIONS:
We characterized the mucosal-associated microbiome present at the time of surgical resection, limiting conclusions on its role in pathophysiology. Furthermore, antibiotic usage and bowel preparation prior to surgery may result in perturbations to microbial flora.

CONCLUSIONS:
The microbiome of complicated diverticulitis is marked by a localized imbalance of sulfur-metabolizing microbes. The abundance of sulfur-reducing microbes may lead to an excess of hydrogen sulfide and subsequent inflammation.
Rapid onset hydroxychloroquine toxicity
Authors: Jeltsch Brida M. , Sarraf David , Madjdpour Darius , Hanson James V. M. , Pfiffner Fatma K. , Koller Samuel , Berger Wolfgang , Barthelmes Daniel , Al-Sheikh Mayss 
Published: March 2023

Abstract

Purpose:
Hydroxychloroquine (HCQ) can cause irreversible damage to the retina, especially when taken over longer periods. The American Academy of Ophthalmology recommends a regimen for dosing, screening and monitoring of patients treated with HCQ. We present an unusual case of a rapid development of severe HCQ-associated-retinopathy already after 2 years after commencing HCQ treatment.

Methods:
Observational case report. Clinical examination, optical coherence tomography (OCT), fundus autofluorescence imaging (FAF), perimetry, full-field & multifocal electroretinography (ERG) were performed. Ancillary tests included neoplastic and paraneoplastic work-up, vitamin levels and whole exome sequencing, in order to rule out other potential causes of a panretinal degeneration.

Results:
We report on a 58-year-old woman with rheumatoid arthritis, treated initially with 200mg HCQ daily for 1 year (daily dose 3.6mg/kg), then 400mg daily for 1 year (daily dose 7.2mg/kg), and a cumulative dose of 216 g. Her medical history was otherwise unremarkable. No family history for inherited retinal conditions. She was referred due to a rapid and sudden progressive and severe concentric visual field constriction, two years after commencing HCQ treatment.

Conclusion:
This case of a rapid-onset, severe panretinal degeneration shortly after start of HCQ treatment suggests underlying mechanisms and risk factors for HCQ toxicity in addition to those previously reported, and a potential need for supplementary screening tests to prevent HCQ toxicity. AAO dosing guidelines of 5 MG/KG should be strictly adhered to in patients receiving HCQ therapy.
Efficacy and safety of Tuina for chronic nonspecific low back pain: A PRISMA-compliant systematic review and meta-analysis
Authors: Yang Juan , Zhou Xuan , Ma Qingyu , Woods Jeffrey T. , Mohabbat Arya B. , Do Alexander , Brault Jeffrey S. , Jensen Mark A. , Shin Kyung-Min , Shen Longbin , Zhao Canghuan , Cheong Kwok Chee Philip , He Kejie , Guo Yu , Chen Zhuoming , Tang Shujie , Tang Yong , Tan Celia Ia Choo , Chen Jiaxu , Bauer Brent A. 
Published: March 2023

Objective:
Chronic nonspecific low back pain (CNLBP) is a serious medical and social problem resulting in functional decline and decreased work ability. Tuina, a form of manual therapy, has been sparsely used to treat patients with CNLBP. To systematically assess the efficacy and safety of Tuina for patients with CNLBP.

Methods:
Multiple English and Chinese literature databases were searched until September 2022 for randomized controlled trials (RCTs) of Tuina in the treatment of CNLBP. The methodological quality was assessed using the Cochrane Collaboration’s tool, and certainty of the evidence was determined with the online Grading of Recommendations, Assessment, Development and Evaluation tool.

Results:
Fifteen RCTs with 1390 patients were included. Tuina demonstrated a significant effect on pain (SMD: −0.82; 95% CI −1.12 to −0.53; P < .001; I
2 = 81%) and physical function (SMD: −0.91; 95% CI −1.55 to −0.27; P = .005; I
2 = 90%) when compared to control. However, Tuina resulted in no significant improvement for quality of life (QoL) (SMD: 0.58; 95% CI −0.04 to 1.21; P = .07; I
2 = 73%;) compared to control. The Grading of Recommendations, Assessment, Development and Evaluation evidence quality was determined to be low level for pain relief, physical function, and QoL measurements. Only six studies reported adverse events; none were serious.

Conclusion:
Tuina might be an effective and safe strategy for treating CNLBP in terms of pain and physical function, but not for QoL. The study results should be interpreted with caution for their low-level evidence. More multicenter, large-scale RCTs with a rigorous design are required to further confirm our findings.
Effect of pre-administration of esketamine intraoperatively on postpartum depression after cesarean section: A randomized, double-blinded controlled trial
Authors: Wang Wei , Ling Bin , Chen Qian , Xu Hua , Lv Jie , Yu Wanyou 
Published: March 2023

Background:
To evaluate the effect of pre-administration of esketamine intraoperatively on the occurrence of postpartum depression after cesarean section under combined spinal-epidural anesthesia.

Methods:
A total of 120 women aged 24 to 36 years undergoing cesarean section by spinal-epidural anesthesia with American Society of Anesthesiologists physical status II were enrolled. According to the intraoperative use of esketamine, all participants were randomly divided into 2 groups: test group (group E) and control group (group C). Esketamine was administered intravenously at a dose of 0.2 mg/kg after the infant was delivered in group E and equal volume of normal saline was given in group C. The incidence of postpartum depression was recorded at 1 week and 6 weeks after the operation. The occurrence of adverse reactions such as postpartum bleeding, nausea and vomiting, drowsiness, and nightmares were also recorded at 48 hours after surgery.

Results:
Compared with group C, the incidence of postpartum depression was significantly lower at 1 week and 6 weeks after surgery in group E (P < .01). There was no significant difference of the adverse effects at 48 hours after the operation between the 2 groups.

Conclusion:
Intravenous infusion of 0.2 mg/kg esketamine in women during cesarean section can significantly reduce the incidence of postpartum depression at 1 week and 6 weeks after surgery without increasing related adverse effects.