bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five-year results of iontophoresis-assisted transepithelial corneal cross-linking for keratoconus
Authors: Roszkowska Anna Maria , Oliverio Giovanni William , Hydzik-Sajak Katarzyna , De Crescenzo Michele , Aragona Pasquale 
Published: July 2023

Abstract
Purpose
To assess long-term efficacy and safety of iontophoresis-assisted transepithelial corneal cross-linking (I-CXL) for keratoconus.

Patients and methods
Twenty-seven eyes of 21 patients (15 M, 6F) affected by progressive keratoconus were evaluated. All subjects were treated with iontophoresis-assisted transepithelial CXL. The patients were examined at baseline and each 6 months after the CXL procedure. Only subjects who completed the follow-up of 5 years were considered in this study. The main outcome measures were uncorrected visual acuity (UCVA), corrected visual acuity (CDVA), corneal transparency and corneal parameters such as K-max, central corneal thickness (CCT) and at the thinnest point, and high-order ocular aberrations (HOAs). The ABCD system was used to determine the progression and re-progression of ectasia.

Setting
Ophthalmology Clinic, University Hospital of Messina, Messina, Italy.

Results
At 5 years, significant improvements of UCVA from 0.53 ± 0.33 logMAR to 0.4 ± 0.33 logMAR (p = 0.001) and HOAs (p = 0.01) were registered. No significant changes of CDVA (p = 0.4), K-max (p = 0.75), CCT (p = 0.5) were observed at the end of follow-up period.
The ABCD system showed re-progression in 25.9% of eyes after 5 years. No adverse events such as corneal opacities and infections were reported.

Conclusions
Iontophoresis-assisted transepithelial CXL resulted to be safe and effective to stabilize progressive keratoconus in adults at a long-term follow-up.
Strengthening the Theoretical Commitments Underpinning Therapeutic Jurisprudence Research: Ontology and Epistemology
Authors: Kawałek Anna 
Published: July 2023

AbstractTherapeutic Jurisprudence is a legal philosophy concerned with the human effects of the law. Its scholarly work promotes greater interaction between law and the social sciences to draw attention to the therapeutic and/or anti-therapeutic side-effects of law. Despite significant headway having been made in therapeutic jurisprudence scholarship during its relatively short lifespan, there remain gaps in theory, not least, in terms of the ontological and epistemological commitments that underpin and drive its research, as well as how its methodology resonates with those from its predecessor schools: legal realism and sociological jurisprudence. This essay will respond to these gaps and, in doing so, will also acknowledge some of the key similarities and differences in the methodological underpinnings of the claims from legal realism and sociological jurisprudence (as well as legal positivism and formalism).
The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)
Authors: AlRuwaili Raed , Al-kuraishy Hayder M. , Alruwaili Mubarak , Khalifa Amira Karam , Alexiou Athanasios , Papadakis Marios , Saad Hebatallah M. , Batiha Gaber El-Saber 
Published: July 2023

AbstractAcute ischemic stroke (AIS) is a focal neurological disorder that accounts for 85% of all stroke types, due to occlusion of cerebral arteries by thrombosis and emboli. AIS is also developed due to cerebral hemodynamic abnormality. AIS is associated with the development of neuroinflammation which increases the severity of AIS. Phosphodiesterase enzyme (PDEs) inhibitors have neuro-restorative and neuroprotective effects against the development of AIS through modulation of the cerebral cyclic adenosine monophosphate (cAMP)/cyclic guanosine monophosphate (cGMP)/nitric oxide (NO) pathway. PDE5 inhibitors through mitigation of neuroinflammation may decrease the risk of long-term AIS-induced complications. PDE5 inhibitors may affect the hemodynamic properties and coagulation pathway which are associated with thrombotic complications in AIS. PDE5 inhibitors reduce activation of the pro-coagulant pathway and improve the microcirculatory level in patients with hemodynamic disturbances in AIS. PDE5 inhibitors mainly tadalafil and sildenafil improve clinical outcomes in AIS patients through the regulation of cerebral perfusion and cerebral blood flow (CBF). PDE5 inhibitors reduced thrombomodulin, P-selectin, and tissue plasminogen activator. Herein, PDE5 inhibitors may reduce activation of the pro-coagulant pathway and improve the microcirculatory level in patients with hemodynamic disturbances in AIS. In conclusion, PDE5 inhibitors may have potential roles in the management of AIS through modulation of CBF, cAMP/cGMP/NO pathway, neuroinflammation, and inflammatory signaling pathways. Preclinical and clinical studies are recommended in this regard.
Graphical abstract
Triple sensing scheme based on nonlinear coupled micromachined resonators
Authors: Fang Zhengliang , Theodossiades Stephanos , Hajjaj Amal Z. 
Published: July 2023

AbstractIn the past few decades, advances in micro-electromechanical systems (MEMS) have produced robust, accurate, and high-performance devices. Extensive research has been conducted to improve the selectivity and sensitivity of MEMS sensors by adjusting the device dimensions and adopting nonlinear features. However, sensing multiple parameters is still a challenging topic. Except for the limited research focus on multi-gas and multimode sensing, detecting multiple parameters typically relies on combining several separate MEMS sensors. In this work, a new triple sensing scheme via nonlinear weakly coupled resonators is introduced, which could simultaneously detect three different physical stimuli (including longitudinal acceleration) by monitoring the dynamic response around the first three lowest vibration modes. The Euler–Bernoulli beam model with three-mode Galerkin discretization is used to derive a reduced-order model considering the geometric and electrostatic nonlinearities to characterize the resonator's nonlinear dynamics under the influence of different stimuli. The simulation results show the potential of the nonlinear coupled resonator to simultaneously perform triple detection.
Rate of Convergence in the Smoluchowski-Kramers Approximation for Mean-field Stochastic Differential Equations
Authors: Son Ta Cong , Le Dung Quang , Duong Manh Hong 
Published: July 2023

AbstractIn this paper we study a second-order mean-field stochastic differential systems describing the movement of a particle under the influence of a time-dependent force, a friction, a mean-field interaction and a space and time-dependent stochastic noise. Using techniques from Malliavin calculus, we establish explicit rates of convergence in the zero-mass limit (Smoluchowski-Kramers approximation) in the $$L^p$$

L
p

-distances and in the total variation distance for the position process, the velocity process and a re-scaled velocity process to their corresponding limiting processes.
Addiction and the Capability to Abstain
Authors: Östlund Sebastian 
Published: July 2023

AbstractAddiction is a widespread problem affecting people from different regions, generations, and classes. It is often analysed as a problem consisting in compulsion or poor choice-making. Recently, however, integrated analyses of compulsion and choice have been called for. In this paper, I argue that the capability approach highlights the well-being loss at stake in cases of addiction, whether they are described as stemming from compulsion, poor choice-making, or some combination thereof. The relevant capabilities obtain when combinations of individual, socio-political, and environmental factors jointly facilitate abstention. On this complementary evaluative analysis, people’s capabilities to abstain are shown to be undermined by how different kinds of factors interact with each other. The upshot is that without committing to an empirical view of the nature of addiction that must capture each case, the capabilitarian analysis helps highlight a central goal of addiction-related well-being policy-work, namely to promote people’s genuine opportunities to abstain.
Temporomandibular joint involvement in patients with Juvenile Idiopathic Arthritis: comparison of ultrasonography and magnetic resonance imaging in assessing the periarticular space width
Authors: Tonni Ingrid , Fossati Giulia , Garo Maria Luisa , Piancino Maria Grazia , Cattalini Marco , Visconti Luca , Borghesi Andrea 
Published: July 2023

Abstract
Objectives
This study aimed to compare the performance of Ultrasonography (US) and Magnetic Resonance Imaging (MRI) in assessing the Lateral Periarticular Space (LPAS) of Temporomandibular Joints (TMJs) in patients with Juvenile Idiopathic Arthritis (JIA).

Methods
The LPAS width was evaluated in two different patient groups. In the JIA group, including 29 children (13 ± 2.8 years) with JIA, the LPAS width was measured with both MRI and US. In the healthy group, including 28 healthy children (12.6 ± 2.5 years), the LPAS width was measured only with US. Comparisons of LPAS width based on patient groups and TMJ contrast enhancement in MRI were evaluated by applying the Mann–Whitney U test. Correlation and agreement between MRI and US measurements in JIA group were tested using Spearman rank correlation and Bland–Altman method.

Results
The LPAS width was significantly greater in the JIA group than in the healthy group. In the JIA group, the LPAS width was significantly greater in TMJs with moderate/severe enhancement than those with mild enhancement. A positive significant correlation between MRI and US measurements of LPAS width was found in the JIA group. In the same group, Bland–Altman method showed a good level of agreement between MRI and US measurements.

Conclusion
Although, US cannot replace MRI in the evaluation of TMJ in patients with JIA, US could be used as a supplementary imaging method to MRI in assessing the TMJ disease.
Profile der Berufswahlmotivation von Studierenden des beruflichen Lehramts und deren Zusammenhänge mit berufsbezogenem Selbstkonzept und Berufswahlsicherheit
Authors: Stellmacher Anne , Paetsch Jennifer 
Published: July 2023

ZusammenfassungBerufswahlmotive von angehenden Lehrkräften können die Entwicklung professioneller Kompetenz im Lehramtsstudium beeinflussen und somit den Studien- und späteren Berufserfolg mitbestimmen. Die vorliegende Studie untersucht erstmals die Berufswahlmotive von Studierenden des beruflichen Lehramts (N = 350) mittels einer latenten Profilanalyse mit dem Ziel, günstige und ungünstige Berufswahlmotivkonstellationen zu identifizieren. Als Indikatoren für Studienerfolg wurden das berufsbezogene Selbstkonzept und die Berufswahlsicherheit herangezogen. Auf Basis der sechs Subskalen des Fragebogens zur Erfassung der Motivation für die Wahl des Lehramtsstudiums (FEMOLA) konnten fünf Profile identifiziert werden. Dabei erwiesen sich zwei als günstig und eines als eher ungünstig. Die günstigen Profile zeichneten sich beide durch eine hohe intrinsische Motivation aus, wobei ein Profil gleichzeitig auch extrinsisch motiviert ist. Beide Profile haben eine hohe Berufswahlsicherheit und hohe Selbsteinschätzungen im berufsbezogenen Selbstkonzept. Das ungünstige Profil hat die höchste Ausprägung in der Nützlichkeitsskala und niedrige interessensbezogene Berufswahlmotive. Bei dieser Gruppe sind die Berufswahlsicherheit und das berufsbezogene Selbstkonzept am geringsten ausgeprägt, sodass diese Berufswahlmotivkonstellation als risikohaft beschrieben werden kann.
Group schemes and motivic spectra
Authors: Garkusha Grigory 
Published: July 2023

AbstractBy a theorem of Mandell, May, Schwede and Shipley [21] the stable homotopy theory of classical S1-spectra is recovered from orthogonal spectra. In this paper general linear, special linear, symplectic, orthogonal and special orthogonal motivic spectra are introduced and studied. It is shown that stable homotopy theory of motivic spectra is recovered from each of these types of spectra. An application is given for the localization functor $${C *}{\cal F}r:{\rm{S}}{{\rm{H}}_{{\rm{nis}}}}(k) \to {\rm{S}}{{\rm{H}}_{{\rm{nis}}}}(k)$$

C
∗

ℱ
r
:

SH

nis

(
k
)
→

SH

nis

(
k
)
in the sense of [15] that converts Morel–Voevodsky stable motivic homotopy theory SH(k) into the equivalent local theory of framed bispectra [15].
Jugend und gesellschaftspolitische Handlungsfähigkeit
Authors: Gröschner Caroline , Schildknecht Lukas 
Published: July 2023

ZusammenfassungWenn Sozialpädagogik mehr sein möchte als tradierende Institution und die Weitergabe bestimmter festgelegter Normen, muss sie ihre Adressat_innen als Handelnde erstnehmen und ihnen Handlungsfähigkeit ermöglichen. Die Generationenkonflikte um Klimagerechtigkeit und Diversität an Schulen zeigen exemplarisch, wie sich kollektive Handlungsfähigkeit Jugendlicher darstellt. Die Ausführungen lenken zudem die Aufmerksamkeit auf die Zentralität von Aushandlungsprozessen in den Praxen der Arbeit mit Menschen.
Co-planning and co-design as progress in the implementation of welfare services
Authors: Becchetti Leonardo , Pisani Fabio , Raffaele Luca 
Published: July 2023

AbstractCo-planning (and co-design) of welfare services between public administrations and civic organisations is an innovative approach aiming to enact and maximise aggregate effort and competence contributions among complementary actors in the direction of participation and active citizenship. In our paper, we develop a simple theoretical framework trying to illustrate how it is possible to pursue the first best of an optimal participated planning, design and management approach for welfare services. We examine pros and cons of different solutions reconciling involvement of civil actors and respect of antitrust principles outlining four benchmark models with different characteristics in terms of upstream and downstream participation levels. We outline policy proposals to solve dilemmas related to the difficulty of jointly activating participation, intrinsic and monetary incentives avoiding in the meanwhile collusion and corruption.
Geomorphology of Abandoned Underground Slate Mines in Czechia
Authors: Schuchová Kristýna , Lenart Jan , Stacke Václav 
Published: July 2023

AbstractWe conducted one of the first complex geomorphological investigations of underground abandoned slate mines in Czechia, Central Europe. Sixty types of subterranean geomorphic forms were described from 114 abandoned underground slate mines in the Nízký Jeseník Upland. The forms, evaluated according to their type, scale, frequency, and fragility, are independent of each other or embedded. Their cascades occur in large multilevel mines affected by fluvial and gravitational processes. Analysis of the microforms revealed mine pearls enriched with titanium, calcareous soda-straw stalactites, amorphous calcareous-sulphurous piles, and quartz veins. Forty-seven of the identified mines were affected by gravitational failures. Four-year measurements of cracks revealed both negligible oscillations and distinct displacement of rock blocks up to 4 mm. The range of described geomorphic forms together with identified cascades and measured crack displacement point to rich geodiversity and high dynamics within the abandoned mines. Compared to other subterranean geosystems, the geomorphology of abandoned underground slate mines remains poorly investigated, although knowledge of subterranean geomorphic systems is crucial for future natural evaluation, risk assessment, remediation, or tourist management of abandoned mining sites. The recent results are applicable to other types of abandoned mines in the world. However, we should expect new findings and investigation of as yet undescribed geomorphic forms.
Unraveling Early Holocene occupation patterns at El Arenal de la Virgen (Alicante, Spain) open-air site: an integrated palimpsest analysis
Authors: Rabuñal José Ramón , Gómez-Puche Magdalena , Polo-Díaz Ana , Fernández-López de Pablo Javier 
Published: July 2023

AbstractPalimpsests are ubiquitous in the open-air archaeological record. Yet, integrated intra-site research strategies of palimpsest dissection to infer occupational histories, spatial behavioural patterns and site formation processes remain scarce in the postglacial archaeology. In this work, we apply an integrated protocol of palimpsest analysis to the Mesolithic Unit IV of El Arenal de la Virgen site, radiocarbon dated in two different occupation phases (9.3–9.1 k and 8.6–8.3 k cal BP). While the archaeostratigraphic analysis identified the absence of sterile layers between both phases, the lithic refits confirmed the good preservation of the spatial properties of the assemblage. Using different point pattern analysis and geostatistical techniques, we further investigate the overall distribution pattern, the spatial correlation between lithic remains and occupation features according to different artefact categories, and the variability of spatial autocorrelation in the frequency of burnt microdebris. Our results suggest a behavioural pattern of different, and spatially recurrent, short-term camp occupation episodes. Built on explicit quantitative and reproducible standards, our research approach can be applied to other open-air sites to conduct comparative studies on open-air occupation patterns. This study underscores the importance of considering the palimpsest as an analytical unit and the need for assessing assemblage integrity and site formation processes through multidisciplinary approaches, to better characterise site occupation dynamics.
Gibbs manifolds
Authors: Pavlov Dmitrii , Sturmfels Bernd , Telen Simon 
Published: July 2023

AbstractGibbs manifolds are images of affine spaces of symmetric matrices under the exponential map. They arise in applications such as optimization, statistics and quantum physics, where they extend the ubiquitous role of toric geometry. The Gibbs variety is the zero locus of all polynomials that vanish on the Gibbs manifold. We compute these polynomials and show that the Gibbs variety is low-dimensional. Our theory is applied to a wide range of scenarios, including matrix pencils and quantum optimal transport.
The Description and Prediction of Incidence, Prevalence, Mortality, Disability-Adjusted Life Years Cases, and Corresponding Age-Standardized Rates for Global Diabetes
Authors: Sun Jianran , Hu Wan , Ye Shandong , Deng Datong , Chen Mingwei 
Published: July 2023

Abstract
Objective
Diabetes is a life-long disease that poses a serious threat to safety and health. We aimed to assess the disease burden attributable to diabetes globally and by different subgroups, and to predict future disease burden using statistical models.

Methods
This study was divided into three stages. Firstly, we evaluated the disease burden attributable to diabetes globally and by different subgroups in 2019. Second, we assessed the trends from 1990 to 2019. We estimated the annual percentage change of disease burden by applying a linear regression model. Finally, the age-period-cohort model was used to predict the disease burden from 2020 to 2044. Sensitivity analysis was performed with time-series models.

Results
In 2019, the number of incidence cases of diabetes globally was 22239396 (95% uncertainty interval (UI): 20599519–24058945). The number of prevalence cases was 459875371 (95% UI 423474244–497980624) the number of deaths cases was 1551170 (95% UI 1445555–1650675) and the number of disability-adjusted life years cases was 70880155 (95% UI 59707574–84174005). The disease burden was lower in females than males and increased with age. The disease burden associated with type 2 diabetes mellitus was greater than that with type 1; the burden also varied across different socio-demographic index regions and different countries. The global disease burden of diabetes increased significantly over the past 30 years and will continue to increase in the future.

Conclusion
The disease burden of diabetes contributed significantly to the global disease burden. It is important to improve treatment and diagnosis to halt the growth in disease burden.
Normal approximation in total variation for statistics in geometric probability
Authors: Cong Tianshu , Xia Aihua 
Published: July 2023

AbstractWe use Stein’s method to establish the rates of normal approximation in terms of the total variation distance for a large class of sums of score functions of samples arising from random events driven by a marked Poisson point process on
$\mathbb{R}^d$
. As in the study under the weaker Kolmogorov distance, the score functions are assumed to satisfy stabilisation and moment conditions. At the cost of an additional non-singularity condition, we show that the rates are in line with those under the Kolmogorov distance. We demonstrate the use of the theorems in four applications: Voronoi tessellations, k-nearest-neighbours graphs, timber volume, and maximal layers.
Description of Paramylonchulus iranicus sp. n. (Nematoda: Mononchida) from Iran
Authors: Aliramaji Farzad , Taheri Abdolhossein , Shokoohi Ebrahim 
Published: July 2023

Abstract
During a survey of soil nematodes in Iran, a population of a species belonging to the order Mononchida was recovered. The new species, Paramylonchulus iranicus sp. n. is characterized by body length (1292–1535 μm in females and 1476–1670 μm in males), c (20.2–29.0 in females and 19.9–27.4 in males), buccal cavity length (23.0–26.0 μm), post vulval uterine sac length (135–162 μm), spicule length (46.0–50.0 μm), gubernaculum length (8.0–11.0 μm), and tail length (49.0–70.0 μm in females and 55.0–73.0 μm in males). Canonical discriminant analysis clearly separated P. iranicus sp. n. from the closely related species Paramylonchulus based on the important morphometric characters of females and males. A molecular study of the 18S rDNA region of P. iranicus sp. n. places this population in a well-supported clade with other species of the genus.
Diet quality, diet-related factors and disability status among male adults of reproductive age in the USA
Authors: Deierlein Andrea L , Litvak Jaqueline , Liu Chang , Stein Cheryl R 
Published: July 2023

AbstractObjective:To examine diet quality and diet-related factors among male adults of reproductive age with and without disabilities.Design:Cross-sectional data from the National Health and Nutrition Examination Surveys, 2013–2018.Setting:Disability was reported as serious difficulty hearing, seeing, concentrating, walking, dressing and/or running errands due to physical, mental or emotional conditions. Diet quality was assessed by the Healthy Eating Index (HEI)-2015 and diet-related factors included self-rated diet healthfulness, food security and food assistance programmes. Multivariable linear regression estimated differences in HEI-2015 scores. Multivariable Poisson regression estimated adjusted prevalence ratios (aPR) and 95 % CI for diet-related factors.Participants:In total, 3249 males, 18–44 years; of whom, 441 (13·4 %) reported having disabilities.Results:Compared with males without disabilities, those with disabilities had a 2·69-point (95 % CI: –4·18, –1·20) lower mean total HEI-2015 score and approximately one-third to half of a point lower HEI-2015 component scores for greens and beans, total protein foods, seafood and plant proteins, fatty acids and added sugars. Males with any disabilities were more likely to have low food security (aPR = 1·57; 95 % CI: 1·28, 2·92); household participation in food assistance programmes (aPR = 1·61; 95 % CI: 1·34, 1·93) and consume fast food meals during the previous week (1–3 meals: aPR = 1·11; 95 % CI: 1·01–1·21 and 4 or more meals: aPR = 1·18; 95 % CI: 1·01–1·38) compared with males with no disabilities.Conclusions:Factors affecting diet and other modifiable health behaviours among male adults of reproductive age with disabilities require further investigation. Health promotion strategies that are adaptive to diverse populations within the disability community are needed.