bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of programmed death‐ligand 1 expression in resected lung cancer and its relationship with EGFR mutation
Authors: Osoegawa Atsushi , Abe Miyuki , Takumi Yohei , Hashimoto Takafumi , Karashima Takashi , Miyawaki Michiyo , Sugio Kenji 
Published: July 2023

AbstractBackgroundSeveral studies have reported that the high expression of programmed death‐ligand 1 (PD‐L1) within tumor cells predicts a poor prognosis. However, the relationship between the PD‐L1 expression and lymph node metastasis or driver mutations in lung cancer remains poorly understood.MethodsA total of 356 consecutive patients who underwent surgical resection for primary lung cancer were included in the study. There were 268 adenocarcinomas including 100 EGFR mutations, 67 squamous cell carcinomas (Sq), and 21 other histologies. The high expression of PD‐L1 was defined as a tumor proportion score (TPS) of ≥50. The relationship between the PD‐L1 expression and clinicopathological factors and recurrence‐free survival (RFS) was analyzed.ResultsThe PD‐L1 expression was high in 75 patients. It was significantly related to smoking history, Sq histology, driver mutation negative, elevated serum carcinoembryonic antigen levels, and lymph node metastasis. Among patients with driver mutations, a high PD‐L1 TPS was found in patients with EGFR G719X mutation. A significant difference in RFS was observed in adenocarcinoma patients. A multivariate analysis of adenocarcinoma cases revealed that tumor size and lymph node metastasis were independent prognostic factors for poor RFS, while the PD‐L1 expression was not. A logistic regression analysis revealed that the absence of driver mutations, lymph node metastasis, and a history of smoking were significantly associated with the high expression of PD‐L1.ConclusionLymph node metastasis was positively related with the high expression of PD‐L1, resulting in poor RFS. A high PD‐L1 TPS was observed in patients with the EGFR G719X mutation.
Brief report: Implementing and evolving suicide prevention strategies at Taoyuan Psychiatric Center inspired by NIC Umbrella review
Authors: Wei Lien‐Chung 
Published: July 2023

AbstractThis brief report discusses the implementation and evolution of suicide prevention strategies at Taoyuan Psychiatric Center in Taiwan. These strategies are inspired by the nursing interventions presented in an “Umbrella review of nursing interventions NIC for the treatment and prevention of suicidal behavior.” The interventions are a part of an employee assistance program (EAP) designed to support the mental health of the nursing staff and other employees, with a particular focus on preventing and managing suicidal behaviors. The EAP involves multi‐tiered primary, secondary, and tertiary prevention measures, offering different levels of psychological interventions.
Integrative genomic and transcriptomic analysis reveals genetic alterations associated with the early progression of follicular lymphoma
Authors: Gao Fenghua , Liu Hengqi , Meng Xiangrui , Liu Jing , Wang Jiesong , Yu Jingwei , Liu Xia , Liu Xianming , Li Lanfang , Qiu Lihua , Qian Zhengzi , Zhou Shiyong , Gong Wenchen , Meng Bin , Ren Xiubao , Golchehre Zahra , Chavoshzadeh Zahra , He Jin , Zhang Huilai , Wang Xianhuo 
Published: July 2023

SummaryFollicular lymphoma (FL), the most common indolent lymphoma, is a clinically and genetically heterogeneous disease. However, the prognostic value of driver gene mutations and copy number alterations has not been systematically assessed. Here, we analysed the clinical‐biological features of 415 FL patients to identify variables associated with disease progression within 24 months of first‐line therapy (POD24). Patients with B symptoms, elevated lactate dehydrogenase and β2‐microglobulin levels, unfavourable baseline haemoglobin levels, advanced stage, and high‐risk FL International Prognostic Index (FLIPI) scores had an increased risk of POD24, with FLIPI being the most important factor in logistic regression. HIST1H1D, identified as a driver mutation, was correlated with POD24. Gains of 6p22.2 (HIST1H1D) and 18q21.33 (BCL2) and loss of 1p36.13 (NBPF1) predicted POD24 independent of FLIPI. Gene expression profiling of FL samples showed that the POD24 cohort was significantly enriched in the inflammatory response (mediated by interferon and tumour necrosis factor), cell cycle regulation (transcription, replication and proliferation) sets and PI3K‐AKT–mTOR signalling. This result was further validated with transcriptome‐wide information provided by RNA‐seq at single‐cell resolution. Our study, performed on a large cohort of FL patients, highlights the importance of distinctive genetic alterations and gene expression relevant to disease diagnosis and early progression.
Psychiatric comorbidities in adults with sickle cell disease: A narrative review
Authors: Mishkin Adrienne D. , Prince Elizabeth J. , Leimbach Elizabeth J. , Mapara Markus Y. , Carroll C. Patrick 
Published: July 2023

SummaryAlthough descriptions of quality of life and patient reports of mood in sickle cell disease (SCD) have become more common in the literature, less is known about psychiatric illness prevalence, presentation, and treatment, particularly for adults. We provide a narrative review of what is known about common and debilitating psychiatric conditions such as depression, anxiety, and cognitive impairment, specifically for adults with SCD. We discuss the limitations of the current evidence, make provisional recommendations, and identify opportunities for research and improved care.
How post‐salt sediment flux and progradation rate influence salt tectonics on rifted margins: Insights from geodynamic modelling
Authors: Pichel Leonardo M. , Huismans Ritske S. , Gawthorpe Robert , Faleide Jan Inge 
Published: July 2023

AbstractContinental rifted margins can be associated with widespread and thick salt deposits, which are often formed during the final stages of rifting, prior to breakup. These salt‐bearing margins are typically characterized by pronounced post‐rift salt tectonics with variable and complex structural styles and evolution. We use a lithosphere‐scale geodynamic numerical model to investigate the role of varying post‐rift sediment fluxes and progradation rates on rifted margin salt tectonics. We focus on a single, intermediate, rifted margin type and salt basin geometry to explore scenarios with different: (i) constant and (ii) time‐varying post‐salt sediment fluxes. We demonstrate that these promote significant contrasts in the style and magnitude of salt tectonics in the proximal, transitional and distal margin domains. The differences are primarily controlled by the relationship between the rates of sediment progradation (Vprog) and salt flow (Vs). When Vprog > Vs, the salt is rapidly buried and both vertical and lateral salt flow are suppressed across the entire margin. When Vprog < Vs, the salt flows vertically and seaward faster than sediments prograde producing major diapirism in the proximal domain and major distal nappe advance, but only moderate overburden extension and distal diapirism. When Vprog ~ Vs, there is moderate proximal diapirism and distal nappe advance, but major updip extension and downdip shortening, which produces major distal diapirism. Modelling results are comparable to various natural systems and help improve our understanding of the controls and dynamics of salt tectonics along salt‐bearing rifted margins.
Co‐producing a complex psychosocial intervention during COVID‐19 with young people transitioning from adolescent secure hospitals to adult services in England: Moving Forward intervention (MFi)
Authors: Livanou Maria , Bull Marcus , Manitsa Ifigeneia , Hunt Jodie , Lane Rebecca , Heneghan Anya 
Published: July 2023

BackgroundYoung people moving from adolescent secure hospitals to adult care present with multiple and complex needs which often remain unmet during transition periods. This paper delineates the process of developing and co‐producing the moving forward intervention (MFi), which aims to address the psychosocial needs of transitioning youth who have limited access to well‐researched and tailored service provisions.MethodAn extensive search of the relevant literature was conducted to generate themes and guide the co‐production phase. Fourteen Advisory Group Meetings were held virtually during COVID‐19 to design the MFi module content with 17 keyworkers, 2 parents and 13 young people aged 17–18 years across six adolescent secure hospitals in England. Thematic analysis was used to reflect on the field notes discussed in the Advisory Groups.ResultsCo‐produced themes from the literature and the Advisory Groups informed the development of the proposed intervention. Three overarching themes pertinent to expectations in adult services, improving communication gaps between services and facilitating the letting go period emerged from the co‐production phase. It was suggested the MFi is co‐delivered by a peer with lived experience to build trust and create hopefulness among young people. The importance of promoting graded transitions through standardised procedures was highlighted.ConclusionsThe current findings promote evidence‐based initiatives and build robust practice frameworks that inform treatment and policy guidelines. The young people, parents and keyworkers found the MFi supportive and valued the co‐production experience. As such, co‐production has been a vital tool in promoting patient engagement and empowerment, and reducing service inequalities, especially in adolescent secure hospitals.
Use of medications associated with weight change among participants in the All of Us research programme
Authors: Almazan Erik , Schwartz Jessica L. , Gudzune Kimberly A. 
Published: July 2023

SummaryOur objective was to describe the use of medications associated with weight change among US adults with overweight/obesity, including anti‐obesity medications (AOMs), weight‐loss‐promoting and weight‐gain‐promoting medications. We performed a cross‐sectional analysis of data from the nationwide All of Us Research Programme. We included adults with measured body mass index (BMI) ≥ 27 kg/m2 enrolled between 2018 and 2022 across the United States. We used linked electronic health record data to determine medication use ±12 months of BMI measure. Our 132 057 participants had mean age 54 years and mean BMI 34 kg/m2; 60% of participants were women, 62% White, and 32% Black. Only 1% used any AOM, and 14% used at least one weight‐loss‐promoting medication. We found that 36% used at least one weight‐gain‐promoting medication, and approximately 20% used multiple weight‐gain‐promoting medications. While AOMs are underutilized by participants with overweight/obesity, weight‐gain‐promoting medication use is common. Our results raise concern about potential iatrogenic weight gain from medications. Future research is needed to estimate the long‐term effect of weight‐gain‐promoting medications on weight status and determine whether weight‐loss benefits occur with their discontinuation. Clinician education on AOMs and weight‐loss‐promoting medications may be needed to increase their use.
Heart rate stability in a clinical setting and after a short exercise in healthy male volunteers
Authors: Wildenbeest Fleur W. H. , Hassing Gert‐Jan , Kemme Michiel J. B. , Moerland Matthijs , Gal Pim 
Published: July 2023

AbstractIntroductionLimited data exist on heart rate stabilization in the domiciled nature of phase I clinical studies, particularly when frequent measurements of QT intervals are involved. The present analysis aimed to evaluate heart rate stability in the domiciled nature of, and stabilization after a short exercise.MethodsFifty‐six healthy male subjects were included in this analysis. Data during a domiciled clinical setting and after a short exercise were analysed. Mean values of 30 s intervals of collected electrocardiographical data (PR, RR, QT and QTcF intervals) during a 10‐min supine resting period in a domiciled nature or after walking up and down three stories (100 steps) were compared to baseline values using paired t‐tests or compared to the intrasubject standard deviation.ResultsStable heart rates and stable QTcF intervals observed immediately upon assuming a supine position in the domiciled clinical setting. After the short exercise, PR interval and RR interval were significantly (p < 0.05) shorter for up to 120 s (mean value −9.8 ± 7.2 ms) and 30 s (−160 ± 165 ms, p < 0.05), respectively. QT and QTcF intervals were significantly (p < 0.05) shorter for up to 90 and 120 s postexercise, respectively. Both QT and QTcF intervals stabilized after 2 min, but QT interval remained prolonged while QTcF interval returned to baseline levels.ConclusionIn a clinical setting, male volunteers do not require a waiting period for electrocardiographic parameter normalization. However, accurate measurement of these parameters following a short exercise necessitates a minimum 2‐min resting interval.
The role of culture on the phenomenology of hallucinations and delusions, explanatory models, and help‐seeking attitudes: A narrative review
Authors: Ghanem Mawada , Evangeli‐Dawson Christian , Georgiades Anna 
Published: July 2023

AbstractAimCulture has been posited to be involved in the formation and maintenance of delusions and hallucinations. The extent of these differences and how they affect explanatory models of psychosis and help‐seeking attitudes remains to be understood. This review aims to present a cultural formulation to account for psychosis onset, symptom maintenance, and help‐seeking attitudes.MethodsA narrative review was conducted to summarize the existing evidence base regarding cross‐cultural differences in hallucinatory and delusional prevalence, explanatory models, and help‐seeking attitudes in First Episode Psychosis (FEP) and Non‐FEP Schizophrenia samples.ResultsSixteen studies were eligible for inclusion. In terms of positive symptom specificity, cross‐cultural differences were found. Specifically, auditory and visual hallucinations occurred most frequently in African patients, persecutory and grandiose delusions occurred at higher rates in African, Pakistani, and Latino patients, while delusions of reference were most prevalent in White‐British groups. Three explanatory models were identified. Westerners tended to endorse a bio‐psychosocial explanation, which was associated with increased help‐seeking, engagement, and positive medication attitudes. Asian, Latino, Polish, and Māori patients endorsed religious‐spiritual explanatory models, while African patients opted for a bewitchment model. The religious‐spiritual and bewitchment models were associated with a longer duration of untreated psychosis (DUP) and poorer engagement with mental health services.ConclusionsThese findings highlight the important influence of culture in the formation and maintenance of positive symptoms of psychosis, engagement, and help‐seeking attitudes across different ethnic groups. The incorporation of cultural beliefs in formulation development could facilitate enriched CBTp practices and improved engagement amongst different cultural groups with Early Intervention Services.
Is the early identification and referral of suspected head and neck cancers by community pharmacists feasible? A qualitative interview study exploring the views of patients in North East England
Authors: Bissett Susan M. , Sturrock Andrew , Carrozzo Marco , Lish Rachel , Howe Debora , Mountain Susan , Nugent Michael , O'Hara James , Todd Adam , Wilkes Scott , Preshaw Philip M. 
Published: July 2023

AbstractIntroductionHead and neck cancer (HNC) is the eighth most common cancer in the United Kingdom. Survival rates improve when the cancer is diagnosed at an early stage, highlighting a key need to identify at‐risk patients. This study aimed to explore opportunistic HNC identification and referral by community pharmacists (CPs) using a symptom‐based risk assessment calculator, from the perspective of patients with a diagnosis of HNC.MethodsPurposive sampling was used to recruit patients from the HNC pathway in three large teaching hospitals in Northern England. Qualitative methodology was used to collect data through an iterative series of semistructured telephone interviews. Framework analysis was utilised to identify key themes.ResultsFour main themes were constructed through the analytic process: (1) HNC presentation and seeking help; (2) the role of the CP; (3) public perception of HNC and (4) the role of a symptom‐based risk calculator. Participants agreed that CPs could play a role in the identification and referral of suspected HNCs, but there were concerns about access as patients frequently only encounter the medicine counter assistant when they visit the pharmacy. HNC symptoms are frequently attributed to common or minor conditions initially and therefore considered not urgent, leading to delays in seeking help. While there is public promotion for some cancers, there is little known about HNC. Early presentation of HNC can be quite variable, therefore raising awareness would help. The use of a symptom‐based risk calculator was considered beneficial if it enabled earlier referral and diagnosis. Participants suggested that it would also be useful if the public were made aware of it and could self‐assess their symptoms.ConclusionIn principle, CPs could play a role in the identification and referral of HNC, but there was uncertainty as to how the intervention would work. Future research is needed to develop an intervention that would facilitate earlier identification and referral of HNC while not disrupting CP work and that would promote HNC and the risk calculator more widely.Patient or Public ContributionPatient and public involvement and engagement (PPIE) was integrated throughout the project. Initially, the proposal was discussed during a Cancer Head and Neck Group Experience (CHANGE) PPIE meeting. CHANGE was set up to support HNC research in 2018. The group is composed of seven members (four female, three male) with an age range of 50–71 years, who were diagnosed at Sunderland Royal Hospital. A patient representative from the University of Sunderland PPIE group and a trustee of the Northern HNC Charity were recruited as co‐applicants. They attended project management group meetings and reviewed patient‐facing documentation.
A multi‐scalar critical analysis of return migration policies in Mexico
Authors: Fernández‐Sánchez Higinio , Salma Jordana , Dorow Sara , Salami Bukola 
Published: July 2023

AbstractServices and resources for migrants returning to Mexico are necessary to ease their transition and “re‐integration” into home communities. Policies that do not have a holistic approach can result in serious implications for the social, political, cultural, and health of returnees, receiving families, and communities. This research critically analyses return migration policies in Mexico drawing from the intersectionality‐based policy analysis framework and a multi‐scalar approach to critically study return migration policies in Mexico. We analysed 20 return migration policies using the principles of the intersectionality‐based policy analysis framework. In 2021, we interviewed those impacted by return migration policies in Veracruz, Mexico to gain deeper insights into return migration policies. Women who stayed behind, return migrants, community leaders, and health‐care providers were interviewed via phone or face‐to‐face in Spanish. Information was transcribed verbatim and analysed with the aid of computer‐assisted data analysis software and quotes were translated into English. They shed light on two major inequities in policies: (1) the lack of acknowledgement of diversity or return migrants and (2) the exclusion of receiving families and communities from the “re‐integration” process of return migrants. Based on the multi‐scalar critical policy analysis, return migration policies in Mexico would benefit from a more comprehensive and inclusive approach where the needs of return migrants and community members are protected based on their diversity.
Enhanced high‐power performance of Fe‐doped PZMNZT piezoelectric ceramics
Authors: Tang Wenbin , Wang Yuequn , Xiang Guanglei , Zhao Xuefeng , Pan Zhiyong , Wang Yiping , Yang Ying , Wang Yaojin , Yuan Guoliang 
Published: July 2023

AbstractHigh‐power piezoelectric ceramics are typically driven to output vibration velocity (v0) under high AC electric fields. Herein, the Fe2O3 doped 0.125 Pb(Zn1/3Nb2/3) O3–0.075 Pb(Mn1/3Nb2/3)O3–0.8 Pb(Zr0.48Ti0.52)O3(PZMNZT–xFe; x = 0.05–0.35) piezoelectric ceramics were prepared to enhance v0, and the favorable comprehensive electrical properties, such as d33 = 315 pC/N, Qm = 1738, kp = 0.58, kt = 0.48, εr = 1156, tan δ = 0.4%, and Tc = 320°C, were achieved in the PZMNZT–0.15Fe ceramic. Most importantly, the PZMNZT–0.15Fe ceramic presented a reliable v0 of 0.90 m/s, which was 2.25 times of the commercial PZT4 ceramic (∼0.40 m/s). The excellent high‐power performance should be attributed to ordering functional elements such as crystal grains and ferroelectric domains. Overall, this work reveals that the PZMNZT–0.15Fe ceramic is competitive for high‐power applications.
Reframing care while enduring the traumatic nature of witnessing disrupted family‐patient‐nurses' relationships during COVID‐19
Authors: dos Santos Maiara Rodrigues , Abbott‐Anderson Kristen , Ponto Julie , Silva Lucas Thiago Pereira , Ferro Tais de Abreu , Schweiss Cy , Eggenberger Sandra , Meiers Sonja , Szylit Regina 
Published: July 2023

AbstractAimTo describe the lived experiences of nurses caring for patients and families in the context of COVID‐19 in Brazil and United States.DesignA phenomenological philosophical approach following the van Manen analysis method.MethodsParticipants were recruited in Brazil and the United States, including nurses working in health care settings caring for COVID‐19 patients. Recruitment used purposive and snowball sampling. Participants completed a demographic survey and semi‐structured interviews that were audio‐recorded and transcribed for analysis. A cross‐cultural examination occurred among researchers from each country.ResultsThe result was described (n = 35) by the themes, representing the essences of each lifeworld (relationship, time, space and body). The nurses' lived experience was one of reframing care while enduring repeated trauma of witnessing disrupted patient‐family‐nurse relationships. Themes were as follows: (a) Living a silent and lonely experience; (b) Providing connectedness for disrupted patient and family relationships; (c) Feeling the burden of the demands; (d) Being a helping connector; (e) Reshaping spaces amidst evolving interventions and policies; (f) Creating safe spaces, surrounded by turmoil, threat, and distress within an unsafe environment; (g) Reorganizing care and reframing time; (h) Reconciling losses, regrets, victories and lessons.ConclusionThe nurses' lived experience of caring for patients and families during the COVID‐19 pandemic prompted the need to respond to repeated traumas and distress posed by interrupted patient‐family and nurse‐own family relationships, vulnerable bodies, threatened space and dynamic and volatile time.ImpactCultural nuances were discovered depending on the practice setting, political discourse and the autonomy of the nurse. Innovative models of care that create structures and processes to support nurses in caring for patients in threatening environments and the commitment to connecting family members have potential to contribute to the ongoing health of the nursing profession.