bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a holistic sensory evaluation three-part method for textiles and apparel: a practical application for novel materials and products
Authors: Ghalachyan Armine , Karpova Elena , Frattali Anastasia 
Published: May 2023

Purpose
This study aims to propose and demonstrate a practical application of a new three-part holistic sensory evaluation (HSE) method for textiles and apparel based on the senses of sight, touch, hearing and smell. HSE method development was carefully documented, described and successfully applied to evaluate sensory characteristics and consumer perceptions and acceptance of bacterial cellulose (BC), a novel sustainable material for apparel.

Design/methodology/approach
In Part One of the HSE method, research participants described the material in their own words based on the senses of sight, touch, hearing and smell. In Part Two, they rated the intensities and their linking for 25 predetermined attributes describing BC. Part Three measured participants’ overall liking of BC and its perceived suitability for apparel and accessories.

Findings
Application of the HSE method resulted in an in-depth understanding of BC material. Areas for material improvements and positive characteristics were identified, providing direction for further development. Consumers found BC suitable for accessories and outer-layer garments but not for apparel.

Originality/value
Sensory evaluation of textiles and apparel has traditionally focused on the senses of touch and sight. The new HSE method allows evaluating the full range of sensory characteristics of materials/products and holistically assessing consumer perceptions. The method is especially useful for novel materials and wearable technology. BC has gained increased interests as a novel sustainable material, yet consumer studies have been lacking. This study reports a comprehensive evaluation of BC material from consumer perspective.
Advancing employee experience management (EXM) platforms
Authors: Abhari Kaveh , Bhullar Aziz , Le Jennifer , Sufi Najma 
Published: May 2023

Purpose
This paper aims to present a novel framework for an artificial intelligence (AI)-powered Employee Experience Management (EXM) platform that addresses strategic HR concerns such as employee engagement, personal and professional development and job satisfaction.

Design/methodology/approach
This paper conducted a comprehensive study of the applications of AI technology in HR management and workforce development between 2020 and 2023. The study results were then contextualized in the context of EXM to identify an innovative employee-centered framework.

Findings
This paper presents a novel framework comprising three essential elements: advanced sentiment analytics, context-sensitive career crafting and augmented mentorship. These elements are introduced with the purpose of enhancing the employee experience by leveraging AI technology to provide personalized support.

Originality/value
This paper presents possibilities and priorities in designing the next generation of EXM platforms. Furthermore, this paper offers criteria for evaluating and selecting emerging EXM technologies to guide organizations in adopting future EXM platforms.
Efficacy and safety of crisaborole ointment in Chinese and Japanese patients aged ≥2 years with mild‐to‐moderate atopic dermatitis
Authors: Ma Lin , Zhang Litao , Kobayashi Michiko , Tao Xiaohua , Qian Qiufang , Cheng Hao , Liu Sujun , Zhou Yangmei , Chen Yayuan , Zhang Jianzhong 
Published: May 2023

AbstractAtopic dermatitis is a chronic inflammatory skin disease with a significant impact on the overall wellbeing of patients and their families. Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor approved for the treatment of mild‐to‐moderate atopic dermatitis in multiple countries. However, in the key pivotal trials, a low proportion of the overall patient population was Asian, therefore the safety and efficacy of crisaborole in the Asian population with atopic dermatitis remains unclear. CrisADe CLEAR was a multicenter, randomized, double‐blind, vehicle‐controlled, phase 3 study (NCT04360187) to assess the efficacy and safety of crisaborole ointment in Chinese and Japanese patients aged ≥2 years with mild‐to‐moderate atopic dermatitis involving ≥5% treatable body surface area. Patients were randomly assigned 2:1 to receive crisaborole or vehicle twice daily for 28 days. The primary endpoint was percentage change from baseline in the Eczema Area and Severity Index total score at day 29. Additional endpoints were improvement and success per Investigator's Static Global Assessment score at day 29 and change from baseline on the Peak Pruritus Numerical Rating Scale at week 4. Safety was assessed using rates of treatment emergent adverse events, serious adverse events, and clinically significant changes in vital signs and clinical laboratory parameters. Crisaborole‐treated patients showed a significantly greater reduction versus vehicle in percentage change from baseline in Eczema Area and Severity Index total score at day 29 (P = 0.0002). Response rates for achievement of Investigator's Static Global Assessment improvement and success at day 29 were significantly higher for patients treated with crisaborole versus vehicle (P = 0.0124 and P = 0.0078, respectively). Crisaborole‐treated patients showed a significantly greater reduction versus vehicle in change from baseline on the Peak Pruritus Numerical Rating Scale at week 4 (P = 0.0009). No new safety signals were identified. Treatment with crisaborole was effective and well tolerated in Chinese and Japanese patients with mild‐to‐moderate atopic dermatitis.
A case of persistent, confluent maculopapular erythema following a COVID‐19 mRNA vaccination is possibly associated with the intralesional spike protein expressed by vascular endothelial cells and eccrine glands in the deep dermis
Authors: Sano Hozumi , Kase Misaki , Aoyama Yukiko , Sano Shigetoshi 
Published: May 2023

AbstractHere, we report an 86‐year‐old Japanese woman presenting with confluent maculopapular erythema, which developed following the second dose of COVID‐19 Messenger RNA (mRNA) vaccine (BNT162b2). Her skin lesions spread over time and persisted for more than 3 months. Surprisingly, immunohistochemical staining of the lesion 100 days after the disease onset revealed the COVID‐19 spike protein expressed by vascular endothelial cells and eccrine glands in the deep dermis. As she had no episode of COVID‐19 infection, it is highly likely that the spike protein was derived from the mRNA vaccine and it might be the cause of the development and persistence of her skin lesions. Her symptoms were prolonged and intractable until oral prednisolone was given.
Individual‐plant selectivity by sheep in drylands scales‐up at plant population level and controls the forage supply and its accessibility
Authors: Oñatibia Gastón R. , Aguiar Martín R. , Oesterheld Martín 
Published: May 2023

Abstract

Diet selectivity by domestic herbivores controls plant community structure and dynamics and may induce rangeland degradation, particularly in drylands. However, management decisions frequently ignore herbivore selectivity. Here, we studied how grass morphology controls sheep selectivity for individual plants, and how this selectivity interacts with grazing intensity to determine population plant‐size distributions and the forage supply.

In Patagonian steppes, we manipulated the plant morphology (size and standing‐dead proportion) of three dominant grass species differentially preferred by sheep for 4 years. Then, we evaluated how these morphological alterations affected intra‐ and inter‐specific preference patterns. We also evaluated how grazing intensity (ungrazed, moderate grazing and intensive grazing) affected the plant‐size distribution of the three species, the forage supply, and its accessibility.

For the highly preferred species, herbivores selected plants that were either naturally or experimentally short, with low proportion of standing‐dead biomass. In contrast, morphological changes did not alter the within‐species selectivity of the least preferred species.

Grazing intensity strongly changed the population plant‐size distribution of preferred species in ways that resembled the experimental manipulations of morphology. Moderate grazing showed the greatest morphological heterogeneity among individuals. When integrating the green biomass of forage species' individuals at ecosystem level, we found that the forage supply was the highest in ungrazed sites and decreased as grazing intensity increased. However, considering the dissuading effect of the standing‐dead proportion of plants, the accessible forage was the highest under moderate grazing.

Synthesis and applications. Our findings (i) showed that, within preferred species, sheep selectivity at individual‐plant level is controlled by morphological characteristics that determine accessibility to green high‐quality biomass. This effect was as important as that of species identity; (ii) empirically proved plant–animal positive feedback at individual level; and (iii) revealed how the individual‐plant selectivity scales‐up at population level and controls the forage supply, but also its accessibility. Our complementary approach generates critical knowledge for developing management practices to control key forage species defoliation and to adjust the grazing pressure to the offer of accessible forage, avoiding the common carrying capacity overestimation. These aspects are essential for sustainable production in grazed drylands.
Participant recruitment for paediatric research using social media: A practical ‘how‐to’ guide for researchers
Authors: Lang Sarah , Day Kaitlin , Gallaher Emma , Jebeile Hiba , Collins Clare E. , Baur Louise A. , Truby Helen 
Published: May 2023

AbstractAimSocial media platforms are being increasingly used to support participant recruitment into paediatric health‐related research. This study aimed to develop a multi‐phase approach for using social media as a recruitment strategy for paediatric research studies.MethodsThe process was informed by the authors’ prior experiences recruiting for paediatric obesity‐related research studies, expertise in social media marketing and digital participant/ patient recruitment. Reflection on these experiences resulted in the iterative creation of a draft process which was further refined. A narrative literature review using a structured search was conducted to refine and augment the content and finalise the process.ResultsA six‐phase recruitment approach was developed that includes: (i) plan for social media use as a recruitment strategy, (ii) explore relevant ethical considerations to protect the wellbeing of potentially vulnerable groups and create an ethical management plan, (iii) identify and understand the different target audiences and develop the advertising strategy, (iv) develop and design campaign content, (v) implement, monitor and iteratively refine the recruitment campaign, (vi) evaluate the campaign success. Potential activities and key considerations relevant for paediatric research are presented within each phase.ConclusionDue to the widespread use and diverse characteristics of social media users, social media has the potential to disseminate details of research opportunities to community members who may otherwise not hear about, engage with, and potentially benefit from research participation. Researchers should collaborate with communication experts and target audiences to generate relevant and effective recruitment campaigns. Researchers should implement processes to protect vulnerable audiences’ wellbeing at each stage of the process. Recruitment via social media may support wider community participation in research studies designed to improve young people's health.
Pitfalls arising from site selection bias in population monitoring defy simple heuristics
Authors: McClure Christopher J. W. , Rolek Brian W. 
Published: May 2023

Abstract

Site selection bias can occur when researchers monitor animals at sites of great abundance, occupancy or quality. The prevailing heuristic is therefore that ecologists should never select sites using these criteria. There is thus concern that common monitoring schemes including surveys at colonies, migratory bottlenecks and artificial breeding sites intentionally monitor sites of great abundance. Whether such routine monitoring schemes likely succumb to site selection bias is unexamined.

We simulate the dynamics of long‐lived vertebrate populations to test three potential pitfalls hypothesized to occur when sites are selected for monitoring based on abundance, occupancy or quality. (1) For regression to the mean, population levels might appear to decline at monitored sites because they were chosen during a peak of abundance and random fluctuations cause populations to decrease from that point. (2) Preferential sampling occurs when some sites are preferred by the focal organism and have an above‐average probability of being selected for monitoring. (3) The missing zero effect occurs when occupied sites are chosen more often for monitoring because of initial or historical occupancy.

Our simulations demonstrate that regression to the mean should only occur when inter‐annual fluctuations in abundance are relatively large compared with the average difference between sites. If researchers monitor sites that are truly of great average abundance, regression to the mean is avoided. Preferential sampling can cause a delay in the detection of a decline because monitored sites are preferred by the focal species and thus should be the first to be occupied and the last to be abandoned. Finally, the missing zero effect can cause a perceived decline in a stable population because sites were chosen when they were initially occupied and thus can only be abandoned, whereas potential colonizations at initially unoccupied sites cannot be observed.

Regression to the mean occurred during specific circumstances that do not seem biologically plausible for some study systems (e.g. colony surveys). It is therefore impractical to apply a single simple heuristic such as ‘never monitor animals at sites of great abundance’ across organisms of varying life histories.
(The Impossibility of) Deliberation‐Consistent Social Choice
Authors: Adachi Tsuyoshi , Chung Hun , Kurihara Takashi 
Published: May 2023

AbstractThere is now a growing consensus among democratic theorists that we should incorporate both “democratic deliberation” and “aggregative voting” into our democratic processes. But how should the two democratic mechanisms of deliberation and voting interact? In this article, we introduce a new axiom, which we call “Nonnegative Response toward Successful Deliberation” (NNRD). The basic idea is that if some individuals change their preferences toward other individuals’ preferences through democratic deliberation, then the social choice rule should not make everybody who has successfully persuaded others through reasoned deliberation worse off than what they would have achieved without deliberation. We prove an impossibility theorem that shows that there exists no aggregation rule that can simultaneously satisfy NNRD along with other mild axioms that reflect deliberative democracy's core commitment to unanimous consensus and political equality. We offer potential escape routes; however, each escape route can succeed only by compromising some core value of deliberative democracy.
Retrospective evaluation of therapeutic plasma exchange treatment in a pediatric intensive care unit: Single‐center experience
Authors: Durak Cansu , Guney Sahin Ebru , Can Yasar Yusuf , Varol Fatih 
Published: May 2023

AbstractBackgroundThe aim of this study is to characterize the clinical indications, outcomes, and complications of therapeutic plasma exchange (TPE) in pediatric intensive care unit.MethodsA retrospective study was conducted on critically ill patients who received TPE. A dataset of 672 treatments administered to 102 patients was analyzed.ResultsThe most common indication for TPE was COVID‐19‐related clinical conditions, followed by sepsis (24.5%), neurological diseases (9.8%) and renal diseases (6.9%). None of our patients died due to TPE‐related complications, and the most common complication during and after the TPE was hypotension (21.7%).ConclusionAlthough TPE is riskier to provide to critically ill children, our experience indicates that it can be performed relatively safely in critically ill children with appropriate treatment indications. In particular, indications, onset time, number of sessions and other procedures should be standardized for the pediatric age group.
Noninvasive finger plethysmography for continuous blood pressure monitoring in patients with left ventricular assist device
Authors: Favilla Christopher G. , Carter Sarah C. , Atluri Pavan , Reehal Navpreet , Genuardi Michael V. 
Published: May 2023

AbstractBackgroundAccurate blood pressure (BP) measurement remains challenging in patients with HeartMate 3™ left ventricular assist devices (HM3 LVADs). The Finapres® NOVA is a promising non‐invasive continuous BP monitor that uses the volume clamp method via a finger cuff, so here we aimed to validate the instrument in HM3 patients.MethodsIn a single‐center cohort, BP was monitored in 15 patients within 72 h following HM3 implantation. A radial artery catheter quantified arterial blood pressure (ABP), while the NOVA measured finger arterial pressure (fiAP) and reconstructed brachial artery pressure (reBAP). Waveforms were recorded for 10 min, and mean values were calculated in 15‐s intervals.ResutsfiAP and ABP were moderately correlated during both the first (ICC 0.61, p = 0.04) and final measurements (ICC 0.66, p = 0.03). reBAP and ABP were strongly correlated during both the first (ICC 0.81, p = 0.002) and final measurements (ICC 0.83, p = 0.001). Both NOVA‐derived values may underestimate low BP values while overestimating relatively high BP values. The reBAP was within 5 mm Hg of the ABP in 40% of patients (and within 10 mm Hg in 67%).ConclusionsThis pilot represents the first evidence in support of the Finapres® NOVA for non‐invasive BP measurement in select patients with HM3 LVADs. The instrument may provide useful data during BP medication adjustments or pump titration, but despite the correlation between the non‐invasive reBAP and invasive ABP, individual‐level inaccuracy may be clinically meaningful. Further investigation is needed to clarify these limitations and optimize accuracy before widespread adoption in this unique patient population.
Do mass layoffs affect voting behaviour? Evidence from the UK
Authors: Braakmann Nils , Vermeulen Wessel N. 
Published: May 2023

AbstractHow bad are mass layoffs politically? We study this question across both regional and individual‐level datasets. Using a difference‐in‐difference framework with differential timing on constituency‐level data for the UK, we find no evidence that mass layoff announcements negatively affect incumbents – either locally or nationally – in the General Elections 2010, 2015, 2017 and 2019. Using individual data on party preferences, we demonstrate that our results are not an artefact of the UK majority voting system and associated tactical voting. We also find no evidence that the null results can be explained by increased outmigration of affected individuals or changes of candidates by political parties. We find evidence that economic expectations are not strongly affected by mass layoffs, which, although a surprising finding by itself, might help to explain the absence of an effect on political outcomes.
Digital inclusion and people with learning disabilities
Authors: Chadwick Darren , Richards Cameron , Molin Martin , Strnadová Iva 
Published: May 2023

Accessible Summaries

The digital inclusion of people with learning disabilities is an important topic because more of our lives are spent using technology and being online.
Articles in this special issue talk about the digital inclusion of people with learning disabilities. We look at their experiences and the experiences of other people in their lives.
The articles talk about how people with learning disabilities use technology and the things that help and stop people from using the internet and technology.
The articles also talk about how using technology helped a lot of people during the coronavirus disease 2019 pandemic.
The articles talk about how people with learning disabilities need choices, opportunities, support and training to make digital inclusion happen so they can use technology like everybody else.
Combination therapy of DKK1 inhibition and NKG2D chimeric antigen receptor T cells for the treatment of gastric cancer
Authors: Zhang Yipeng , Liang Kaijie , Zhou Xiaoyu , Zhang Xin , Xu Hui , Dai Hongjiu , Song Xueru , Yang Xueyi , Liu Baorui , Shi Tao , Wei Jia 
Published: May 2023

AbstractDespite the successful application of chimeric antigen receptor (CAR)‐T cell therapy in hematological malignancies, the treatment efficacy in solid tumors remains unsatisfactory, largely due to the highly immunosuppressive tumor microenvironment and low density of specific tumor antigens. Natural killer group 2 member D (NKG2D) CAR‐T cells have shown promising treatment effects on several cancers such as lymphoma and multiple myeloma. However, the application and efficacy of NKG2D‐CAR‐T cells in gastric cancer (GC) still needs further exploration. This study identified a novel combination immunotherapy strategy with Dickkopf‐1 (DKK1) inhibition and NKG2D‐CAR‐T cells, exerting synergistic and superior antitumor effect in GC. We show that the baseline expression of NKG2D ligands (NKG2DLs) is at low levels in GC tissues from The Cancer Genome Atlas and multiple GC cell lines including NCI‐N87, MGC803, HGC27, MKN45, SGC7901, NUGC4, and AGS. In addition, DKK1 inhibition by WAY‐262611 reverses the suppressive tumor immune microenvironment (TIME) and upregulates NKG2DL expression levels in both GC cell lines and GC tissues from a xenograft NCG mouse model. DKK1 inhibition in GC cells markedly improves the immune‐activating and tumor‐killing ability of NKG2D‐CAR‐T cells as shown by cytotoxicity assays in vitro. Moreover, the combination therapy of NKG2D‐CAR‐T and WAY‐262611 triggers superior antitumor effects in vivo in a xenograft NCG mouse model. In sum, our study reveals the role of DKK1 in remodeling GC TIME and regulating the expression levels of NKG2DLs in GC. We also provide a promising treatment strategy of combining DKK1 inhibition with NKG2D‐CAR‐T cell therapy, which could bring new breakthroughs for GC immunotherapy.