bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflow-Velocity and Rotational Effects on Revolving and Translating Wings
Authors: Paulson James , Jardin Thierry , Buchholz James 
Published: August 2023

Abstract
An aspect ratio 9.5 rectangular wing is articulated in revolving and translating motions
at a 45-degree angle of incidence and Reynolds number Re = O(300). The effects of
rotational (Coriolis and centripetal) accelerations and relative inflow velocity profile on
vorticity transport within the LEV system are independently investigated. For the range of
displacements studied (180 deg. rotation and corresponding translational displacement), a
stably attached leading-edge vortex (LEV) is observed when rotational accelerations and/or
a linearly-varying inflow velocity profile is present; however, the inflow velocity profile has
a stronger effect on stability of the LEV. LEV vorticity magnitude and lift are significantly
augmented when both factors are included (i.e. the full revolving wing case). Vorticity
transport analyses are conducted in a planar control region two chords from the axis of
rotation, where LEV stability is typically observed on revolving wings at high incidence,
and at an equivalent spanwise position in the translating case. The fully revolving wing
case exhibits a substantially larger leading-edge shear-layer vorticity flux than the other
cases, whereas Coriolis tilting makes little contribution to regulation of LEV strength. A
correlation is found between the spanwise convective flux and tilting flux contributions in
all cases. Decomposition of the spanwise convective flux term demonstrates that the two
phenomena are kinematically linked and, together, define a new out-of-plane convective
flux term that captures the essence of the spanwise convective flux. The role of this term
and the effect of rotational accelerations on it are examined.
An asymmetrical multilevel inverter with low voltage stress and fewer components for photovoltaic system
Authors: Memon Rabail , Mahar Mukhtiar Ahmed , Larik Abdul Sattar , shah Syed Asif Ali 
Published: August 2023

Abstract
In this proposed work, a new asymmetrical MLI with an optimal number of components for photovoltaic (PV) system is presented. The purpose of this research is to decrease the component count for generating higher output voltage levels with a low standing voltage and cost of the system than other existing topologies of MLI. To enhance the number of output levels, the magnitudes of DC sources are selected in binary order. This article compares the proposed MLI with other topologies based on the DC sources, total standing voltage per unit (TSV-PU ), cost function per level (CF/L), switch count, gate drivers, and components count per level (CC/L). Solar panels with DC-DC converters with fuzzy logic controllers are used as the DC sources of the new topology of MLI. The performance of the proposed topology at step change in solar irradiance and variable loads has been analyzed. To reduce the total harmonic distortion (THD), phase opposition disposition pulse width modulation (POD-PWM) technique is implemented in the proposed system. The simulation results reveal improved performance at a step change in irradiance and under different loads. The suggested inverter is preferable since it has less component count with minimum voltage stress when compared to traditional MLI topologies. Therefore, its installation requires less space and costs. In summary, it offers overall improved performance. Thus, it is feasible for the PV system.
2X2 MIMO Wireless Communication System with Alamouti coding using single USRP 2944R
Authors: C SHYAMALA , J Jayanth , M Shivakumar , S Vedha A 
Published: August 2023

Abstract
Wireless Communication demands high data rate and reliability. With the deployment of multiple antennae at the transmitter and receiver end, this could be achieved to a large extent. Multi antenna technology generally known as MIMO (Multiple Input Multiple Output) refers to a communication circuit created with multiple transmitter antenna and multiple receiver antenna. In MIMO, Space Time Block Coding (STBC) is a technique used to improve data rate, spectral efficiency, and power utilization. Alamouti Coding is a special STBC transmit diversity scheme used to enhance reliability in Communication. In this paper, a 2x2 MIMO with Alamouti scheme is implemented using USRP (Universal Software Radio Peripheral) 2944R along with NI LabVIEW. The Bit Error Rate (BER) is computed for this scenario for different iterations and performance is studied. Keywords—Alamouti, STBC, Spatial diversity, BER, MIMO, USRP, LabVIEW.
Quantifying Hierarchy and Prestige in US Ballet Academies as Social Predictors of Career Success
Authors: Herrera-Guzmán Yessica , Gates Alexander J. , Candia Cristian , Barabasi Albert-László 
Published: August 2023

Abstract
In the recent decade, we have seen major progress in quantifying the behaviors and the impact of scientists, resulting in a quantitative toolset capable of monitoring and predicting the career patterns of the profession. It is unclear, however, if this toolset applies to other creative domains beyond the sciences. In particular, while performance in the arts has long been difficult to quantify objectively, research suggests that professional networks and prestige of affiliations play a similar role to those observed in science, hence they can reveal patterns underlying successful careers. To test this hypothesis, here we focus on ballet, as it allows us to investigate in a quantitative fashion the interplay of individual performance, institutional prestige, and network effects. We analyze data on competition outcomes from 6,363 ballet students affiliated with 1,603 schools in the United States, who participated in the Youth America Grand Prix (YAGP) between 2000 and 2021. Through multiple logit models and matching experiments, we provide evidence that schools' strategic network position bridging between communities captures social prestige and predicts the placement of students into jobs in ballet companies. This work reveals the importance of institutional prestige on career success in ballet and showcases the potential of network science approaches to provide quantitative viewpoints for the professional development of careers beyond science.
Defining Predictors for Successful Mechanical Ventilation Weaning, Using a Data-mining Process and Artificial Intelligence
Authors: MENGUY Juliette , DE LONGEAUX Kahaia , BODENES Laetitia , HOURMANT Baptiste , L'HER Erwan 
Published: August 2023

Abstract
Objectives: Mechanical ventilation weaning within intensive care units (ICU) is a difficult process, while crucial when considering its impact on morbidity and mortality. Failed extubation and prolonged mechanical ventilation both carry a significant risk of adverse events. We aimed to determine predictive factors of extubation success using data-mining and artificial intelligence.
Design: A prospective physiological and biomedical signal data warehousing project.
Setting: A 21-beds medical Intensive Care Unit of a University Hospital.
Patients: Adult patients undergoing weaning from mechanical ventilation.
Interventions: None.
Measurements and Main Results: Hemodynamic and respiratory parameters of mechanically ventilated patients were prospectively collected and combined with clinical outcome data. One hundred and eight patients were included, for 135 spontaneous breathing trials (SBT) allowing to identify physiological parameters either measured before or during the trial and considered as predictive for extubation success. The Early-Warning Score Oxygen (EWSO2) enables to discriminate patients deemed to succeed extubation, at 72-hrs and 7-days. Cut-off values for EWSO2 (AUC=0.80; Se=0.75; Sp=0.76), mean arterial pressure and heart-rate variability parameters were determined. A predictive model for extubation success was established including body-mass index (BMI) on inclusion, occlusion pressure at 0,1sec. (P0.1) and heart-rate analysis parameters (LF/HF) both measured before SBT, and heart rate during SBT (global performance 62% ; 83%).
Conclusion: The data-mining process enabled to detect independent predictive factors for extubation success and to develop a dynamic predictive model using artificial intelligence. Such predictive tools may help clinicians to better discriminate patients deemed to succeed extubation and thus improve clinical performance.
Analysis of 225 cases of cervical glandular lesions from the Papanicolaou test to total hysterectomy
Authors: qin yan , Ling Yuexian , Gao Hongyi 
Published: August 2023

Abstract
Objective To explore the relative sensitivity of different methods for detecting cervical neoplasia including the Papanicolaou test, cervical biopsy and/or endocervical curettage (ECC), and the subsequent diagnosis following a loop electrosurgical excision procedure (LEEP), cold knife conization (CKC) or hysterectomy.
Methods A total of 225 patients with cervical glandular lesions diagnosed from January 2018 to February 2023 were retrieved from the pathology database of Guangdong Maternal and Child Health Hospital, and their clinicopathological features were reviewed.
Results Nineteen cases of cervical adenocarcinoma in situ (AIS), 71 cases of cervical adenocarcinoma (ADC) ，and 135 cases of mixed adenosquamous lesion (AIS or ADC complicated with low-grade squamous intraepithelial lesion(LSIL) or high-grade squamous intraepithelial lesion (HSIL) or squamous cell carcinoma (SCC) were identified. Their respective median ages were 38 and 46 years Four human papillomavirus (HPV) genotypes: HPV18, 16, 45, and 52, dominated all glandular lesions, and accounting for 72.09% of HPV-positive tumors. Furthermore,approximately one-third (36.89%) of abnormal squamous cells were diagnosed as abnormal based on cytological examinations leading to the detection of cervical glandular lesions; only 16.89% were diagnosed based on the initial detection of abnormal glandular cytology. The most common abnormal cervical screening result was ASC-US on cytology (14.22%), followed by HSIL (11.56%). Only afew number of patients were diagnosed with or suspected of having cervical adenopathy via a Pap test (18.22%). Nearly one-third of cervical glandular lesions cases were not detected on the Pap test; but were diagnosed upon cervical biopsy or based on the histological examination of ECC, LEEP, or CKC specimens. All 225 patients (100%) underwent biopsy and/or ECC, 120 patients (44.44%) underwent LEEP or CKC biopsy, and 178 (79.11%) undertook total hysterectomy. The LEEP or CKC biopsy specimens had negative margins in 49 cases (40.83%), while the margins were positive in the other 71 cases (59.17%). Five cases (10.20%) with negative margins still had residual lesions following total hysterectomy, and 19 (26.76%) with positive margins had no residual lesions after total hysterectomy.
Conclusion Our results indicated that the ability to detect cervical glandular lesions varies for routine HPV genotyping, Pap test, or biopsy/ECC, with different sensitivities and advantages and disadvantages for each method. Further standardization is needed for cervical cancer screening in China.
Lower Rounds Lattice-based Anonymous AKA under the seCK model for the IoT
Authors: Wei Guanglu , Fan Kai , Zhang Kuan , Wang Haoyang , Wang Yirui , Yang Kan , Li Hui , Yang Yintang 
Published: August 2023

Abstract

The authenticated key agreement (AKA) method used in the Internet of Things (IoT) provides identity authentication and agreed symmetric keys to encrypt large amounts of communication messages for devices and servers. With the development of the quantum computing techniques and corresponding algroithms, classical authenticated key agreement methods based on public key, such as RSA and ECC become vulnerable. Many scholars have proposed lattice-based authenticated key agreement schemes to achieve post-quantum security and address this issue. However, these scheme's security models (such as BR, CK, and ROR) only can capture limited types of adversary attacks and require many communication rounds. To this end, we propose a lower communication rounds lattice-based anonymous authenticated key agreement (LA-AKA) protocol under the seCK model, which can capture a wider range of adversary attacks. The LA-AKA scheme utilizes an identity-based public key system for key agreement, and this system avoids complex resource consumption caused by certificate verification. During the identity authentication and key agreement phase, the communication entities do not need to transmit static public keys; they only need to engage in two communication rounds to generate the session key. Furthermore, the LA-AKA scheme can resist signal leakage attacks caused by key reuse in the ring learning with errors (RLWE) security assumption. The LA-AKA scheme provides higher security, as security analysis proves. The performance evaluation shows that as the number of devices and servers in the system increases, the computational advantage of the LA-AKA scheme in the broadcast channel becomes more significant.
Stuck in the mud: experimental taphonomy and computed tomography demonstrate the critical role of sediment in three-dimensional carcass stabilization during early fossil diagenesis
Authors: Waskom Madeleine , Losso Sarah , Ortega-Hernández Javier 
Published: August 2023

Abstract

Exceptionally preserved fossils provide critical information on the morphology and ecology of extinct organisms, but their formation remains poorly understood. Experimental taphonomy has produced critical insights that allow us to better understand preservation biases, but they typically do not reflect realistic depositional environments, employ destructive sampling, and are restricted to a two-dimensional setting. Here, we utilize micro-computed tomography to non-invasively visualize the process of decay of carcasses of the branchiopod Triops longicaudatus for a year of post-burial decay. The earliest stages of post-burial diagenesis are dynamic and produce marked differences in relative density within each of the experimental replicates affecting both the carcass and the surrounding sediment. After 64 weeks, specimens are still detectable as three-dimensional voids that capture the body in life position and external morphological features. Sediment plays a critical role in carcass stabilization and the resulting voids provide sites for mineral precipitation needed for exceptional three-dimensional fossilization.
Modified Diets and Medication in Dysphagia – The effect of thickener on drug bioavailability: A systematic review
Authors: Atkin Jayne , Devaney Christopher , Yoshimatsu Yuki , Smithard David 
Published: August 2023

Abstract
Introduction
Dysphagia is associated with long-term conditions including strokes, dementia, Parkinson’s disease and frailty. Dysphagia affects 30-40% of the population aged over 65-years-old. Adults with dysphagia are likely to experience long-term conditions requiring multiple medications (often >5) to manage this. The thickening of liquids is a common compensatory strategy in dysphagia management. Studies suggest that immersion in thickened liquids affects medicines’ solubility in vitro. Clinicians and pharmacists are unaware of the pharmacokinetic/therapeutic effects of thickened liquids on oral medicines. We conducted a systematic review of existing literature on thickeners’ effects on drug bioavailability.
Methodology
We performed a literature search of MEDLINE and EMBASE. Search terms included: dysphagia/thickened diet (EMBASE only)/ bioavailability or absorption of medicines or pharmacokinetics; excluded: NG feeds/animal studies. Studies included: all genders, countries, >18 years, community and hospital settings. PRISMA guidance was followed.
Results
526 results were found and 15 articles identified following reference list review. Following abstract review, 508 were rejected. 33 received a full text review, 18 were rejected, and the remaining 15 included. Most articles evaluated the effect of thickeners on dissolution profiles of medications in-vitro. Few studies assessed bioavailability or used clinical outcome measures. Often these were small studies on limited numbers of medications.
Conclusion
Despite dysphagia and polypharmacy being common in older adults, little is known about the effects of altering liquid viscosity on the pharmacokinetics and therapeutic effect of most medications. Small single-centre studies suggest that immersion in thickener may negatively affect drug pharmacokinetics and therapeutic outcomes.
Prebiotic inulin ameliorates SARS-CoV-2 infection by modulating the gut microbiome and increasing DCA formation in a Syrian hamster model
Authors: Fukuda Shinji , Song Isaiah , Yang Jiayue , Saito Misa , Hartanto Tenagy , Nakayama Yasunori , Ichinohe Takeshi 
Published: August 2023

Abstract
Current treatment options for COVID-19 are limited, with many antivirals and immunomodulators restricted to the most severe cases and preventative care limited to vaccination. As the SARS-CoV-2 virus and its increasing variants threaten to become a permanent fixture of our lives, this new reality necessitates the development of cost-effective and accessible treatment options for COVID-19. Studies have shown that there are correlations between the gut microbiome and severity of COVID-19, especially with regards to production of physiologically beneficial short-chain fatty acids (SCFAs) by gut microbes. In this study, we used a Syrian hamster model to study how dietary consumption of the prebiotic inulin affected morbidity and mortality resulting from SARS-CoV-2 infection. After two weeks of observation, we discovered that inulin supplementation attenuated morbid weight loss and increased survival rate in hamster subjects. An analysis of microbiome community structure showed significant alterations in 15 genera. Notably, there were also small increases in fecal DCA and a significant increase in serum DCA, perhaps highlighting a role for this secondary bile acid in conferring protection against SARS-CoV-2. In light of these results, inulin and other prebiotics are promising targets for future investigation as preventative treatment options for COVID-19.
Elucidation of essentiality of lumazine synthase (RibH) for Mycobacterium tuberculosis survival and discovery of potent inhibitors for enhanced antimycobacterial therapy
Authors: Singh Monica , Dhanwal Anannya , Verma Arpita , Augustin Linus , Kumari Niti , Chakraborti Soumyananda , Agarwal Nisheeth , Sri Dharmarajan , Dey Ruchi Jain 
Published: August 2023

Abstract
Tuberculosis (TB) remains a pressing global health crisis, necessitating urgent interventions to combat drug resistance and improve treatment efficacy. In this study, we elucidate the essential role of lumazine synthase (RibH) for the survival of Mycobacterium tuberculosis (M. tb). Through CRISPRi-based gene knockdown in M. tb, we confirm that deficiency of RibH – the penultimate enzyme in riboflavin biosynthesis cannot be compensated by exogenous supply of Riboflavin, FAD, or FMN. Further, by high-throughput molecular docking-based virtual screening of ~600,000 compounds and in vitro whole cell growth assays, we identify 3 RibH inhibitors that exhibit potent antimycobacterial activity. These compounds also effectively eradicate intracellular M. tb during macrophage infection and prevent the resuscitation of the nutrient-starved persister mycobacteria. Furthermore, they synergistically enhance the bactericidal effect of Isoniazid and Rifampicin. These compounds exhibit high affinity binding to lumazine synthase in vitro and display favorable absorption, distribution, metabolism and excretion (ADME) properties, toxicity profiles, with a high selective index in mammalian cells. By providing mechanistic evidence for the essentiality of RibH in M. tb survival and identification of potent inhibitors that bind to RibH, this study contributes to the development of superior TB treatment strategies and advances the global fight against this devastating disease.
The effects of a CBT-I based app-program on sleep quality, insomnia severity, psychological strain and quality of life: A first efficacy study
Authors: Eigl Esther-Sevil , Hinterberger Alexandra , Topalidis Pavlos , Schabus Manuel 
Published: August 2023

Abstract
Given rising numbers in sleep disorders and insufficient availability of treatment options, the need for well-validated digital interventions rises.
This study aims at assessing the efficacy of an app-program which combines sleep-training based on core elements of Cognitive Behavioural Therapy for Insomnia (CBT-I) with reliable sleep-monitoring based on heart rate variability via an ECG-sensor.
Data of 48 participants (26 female) aged 30-73 (M=50.33±11.88) were included in the analyses. At the beginning of the baseline (T0), at start (T1) and end (T2) of the 6-week training phase as well as 4 weeks after the end of the program (T3; follow-up) several questionnaires assessing sleep quality, insomnia severity, general psychological symptom severity, depression, anxiety as well as quality of life were completed.
Insomnia severity (p<.001), sleep quality (p<.001), general psychological symptom severity (p<.001), depression (p=.002) and anxiety (p<.001) improved significantly during the training phase and persisted until one-month follow-up assessment, while in sleep quality a trend for further improvement during the follow-up period was found (p=.097). Furthermore, quality of life [physical (p=.014) and psychological health (p=.049)] improved significantly during the follow-up-period.
This study adds evidence on the potential of digital interventions and indicates that digital CBT-I can have substantial effects on relevant sleep- and health-related outcome measures.
Hsa_circ_0009092/miR-665/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment
Authors: song jialin , Liu Qing , Han Lei , Song Tiantian , Huang Sihao , Zhang Xinyao , He Qiuming , Liang Chenxi , Zhu Shuai , xiong Bin 
Published: August 2023

Abstract
Background: It has been demonstrated that circular RNA (circRNAs) plays a critical role in various cancers. While the potential molecular mechanism of circRNAs in the progression of colorectal cancer (CRC) remains uncertain.
Methods: Differentially expressed circRNAs were identified by RNA sequencing. RT-qPCR detected the expression of circ_0009092, miR-665, and NLK in CRC tissues and cells. Functions of circ_0009092 on tumor cell proliferation, migration, and invasion were investigated by a series of in vitro assays. The underlying mechanism of circ_0009092 was explored by bioinformatics analysis, RNA immunoprecipitation (RIP) and luciferase assays. A co-culture assay in vitro was performed to detect the affection of circ_0009092 on macrophage recruitment in the tumor microenvironment (TME). A xenograft mouse model was used to explore the effect of circ_0009092 on tumor growth.
Results: Circ_0009092 was downregulated in CRC and predicted a good prognosis. Overexpression of circ_0009092 reduced tumor cell EMT, proliferation, migration, and invasion in vitro and in vivo. Mechanistically, circ_0009092 elevated the NLK expression via sponging miR-665 and suppressed the Wnt/β-catenin signaling pathway. EIF4EA3 induced circ_0009092 expression in CRC cells. In addition, NLK regulates phosphorylation and O-GlcNAcylation of STAT3 by binding to STAT3, thereby inhibiting CCL2 expression, in which it inhibits macrophage recruitment in the tumor microenvironment (TME).
Conclusion: EIF4A3 suppressed circ_0009092 biogenesis, which inhibits CRC progression by sponging miR-665 to downregulate NLK. Circ_0009092/miR-665/NLK suppressed tumor EMT, proliferation, migration, and invasion by acting on the Wnt/β-catenin signaling pathway. NLK directly interacted with STAT3 and decreased the CCL2 expression, inhibiting the recruitment of tumor-associated macrophages (TAMs) in the TME. Our study provided novel insights into the roles of circ_0009092 as a novel promising prognostic and therapeutic target in CRC.