bluuebunny/crossref_metadata_2025_split huggingface dataset:
ИЗУЧЕНИЕ IN VITRO ВЛИЯНИЯ ГОМОЦИСТЕИНОВОГО ЛИНКЕРА НА ПОВЕДЕНИЕ КОНЪЮГАТОВ СЫВОРОТОЧНОГО АЛЬБУМИНА ЧЕЛОВЕКА И МОНОМЕТИЛАУРИСТАТИНА F
Authors: ВАН М. , РОГАЛЕВА В.И. , ПОПОВА Т.В. , ЗАХАРОВА О.Д. , ГОДОВИКОВА Т.С. , СИЛЬНИКОВ В.Н. 
Published: January 2025

Синтезированы флуоресцентные конъюгаты сывороточного альбумина человека и цитостатического препарата - монометилауристатина F, имеющего расщепляемый пептидный линкер ValCit. В синтезе использованы стратегии прямого присоединения терапевтического пептида к альбумину и присоединение с помощью N-трифторацетилгомоцистеинового линкера. Методом конфокальной микроскопии установлено, что конъюгат, содержащий гомоцистеиновый линкер, эффективно накапливается в цитоплазме опухолевых клеток линии MCF-7, в то время как конъюгат, полученный прямым присоединением пептида к белку, накапливается преимущественно на поверхности клеток. Исследования конъюгатов in vitro на линиях клеток MCF-7 и T98G выявили проявление большей цитотоксичности монометилауристатина F в отношении раковых клеток линий MCF-7 и T98G после его присоединения к альбумину. Установлено, что конъюгат, содержащий гомоцистеиновый линкер, проявлял большую цитотоксичность в сравнении с конъюгатом, полученным прямым присоединением монометилауристатина Fк альбумину, несмотря на меньшую нагрузку белка терапевтическим пептидом.
Fluorescent conjugates of human serum albumin and a maleimide derivative of monomethyl auristatin F containing the cleavable peptide linker ValCit were synthesised. Strategies included the direct attachment of the peptide to the albumin structure and the attachment of the peptide through the N-trifluoroacetylhomocysteine linker. Confocal microscopy showed that the conjugate with the homocysteine linker effectively accumulated in the cytoplasm of the MCF-7 tumor cells, whereas the conjugate without the linker displayed predominant surface accumulation. In vitro studies demonstrated that the monomethyl auristatin F conjugate exhibited enhanced cytotoxicity against MCF-7 and T98G cancer cells after its attachment to albumin. The homocysteine-containing conjugate showed superior cytotoxicity compared to the conjugate without the linker despite the lower peptide load.
ОЦЕНКА ПАРАМЕТРОВ ТЕРМИЧЕСКОЙ ДЕСТРУКЦИИ НАНОКОМПОЗИТОВ ТЕЛЛУРИДА ВИСМУТА НА ОСНОВЕ ПОЛИАНИЛИНА
Authors: ЖМУРОВА А.В. , ЛОГИНОВ Б.А. , ЗВЕРЕВА М.В. 
Published: January 2025

Исследовано влияние наночастиц теллурида висмута (Bi2Te3) и многостенных углеродных нанотрубок (МУНТ) на термическую деструкцию и морфологию поверхности их нанокомпозитов с полианилином (ПАНИ) при различном содержании нанофазы (Bi2Te3 - 7.3 мас. %, МУНТ - 1.5 мас. %), впервые полученных с использованием механохимического подхода. На основе данных синхронного термического анализа и сканирующей туннельной микроскопии показано, что введение неорганической нанофазы ключевым образом влияет на термические свойства синтезированных композитов ПАНИ-Bi2Te3 и ПАНИ-Bi2Te3-МУНТ, а также на их структуру. При этом термостойкость нанокомпозитов и исходной полимерной матрицы, оцениваемая по температуре начала второй стадии потери массы образца, совпадает и составляет 166 °C.
The effect of bismuth telluride (Bi2Te3) nanoparticles and multi-walled carbon nanotubes (MWCNTs) on thermal destruction and surface morphology of their nanocomposites with polyaniline (PANI) at different nanophase contents (Bi2Te3 - 7.3 wt%, MWCNTs - 1.5 wt%), obtained for the first time using the mechanochemical approach, has been investigated. It is shown on the basis of the data obtained by synchronous thermal analysis and scanning tunnelling microscopy that the introduction of inorganic nanophase has a key effect on the thermal properties of the synthesised composites PANI-Bi2Te3 and PANI-Bi2Te3-MWCNTs, as well as on their structure. The thermal stability of nanocomposites and the initial polymeric matrix, assessed from the temperature of the onset of the second mass loss stage, is the same and equal to 166 °C.
СОПОСТАВИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ХИМИКО-ТЕХНОЛОГИЧЕСКИХ СВОЙСТВ И МОЛЕКУЛЯРНОГО СТРОЕНИЯ УГЛЕЙ МЕСТОРОЖДЕНИЙ РОССИИ И МОНГОЛИИ КАК СЫРЬЯ ДЛЯ ТЕХНОЛОГИЧЕСКОЙ ПЕРЕРАБОТКИ
Authors: КУЗНЕЦОВ П.Н. , АВИД Б. , ОБУХОВА А.В. , КУЗНЕЦОВА Л.И. , КОСИЦЫНА С.С. , ЛЫРЩИКОВ С.Ю. , ПУРЕВСУРЕН Б. , ЗАОСТРОВСКИЙ А.Н. , ИСМАГИЛОВ З.Р. 
Published: January 2025

Представлены результаты химического, технического и петрографического анализа образцов углей разной стадии углефикации, отобранных на различных месторождениях России и Монголии. С применением метода 13C ЯМР-спектроскопии в твердом теле с использованием техники кросс-поляризации и вращения образца под магическим углом (CP/MAS 13C ЯМР) изучены особенности молекулярного строения углеродного каркаса органической массы, установлены существенные различия в строении поликонденсированных ароматических структур, сделана оценка в соотношении пери- и катаконденсированных ароматических ядер в зависимости от степени углефикации. Выполнен корреляционный анализ, установлены взаимосвязи между различными химико-технологическими параметрами углей и показателями их молекулярного строения. Наиболее тесная связь существует между степенью ароматичности углей, долей периконденсированных структур, выходом летучих веществ и коэффициентом отражения витринита. Установленные особенности молекулярного строения органической массы углей и выявленные регрессионные зависимости могут служить физико-химической основой выбора углей для получения поликонденсированных ароматических веществ как сырья для производства углеродных материалов.
The results of chemical, proximate and petrographic analysis of coal samples at different coalification stages from various deposits in Russia and Mongolia are presented. Features of the molecular structure of the carbon framework in the organic matter were studied by the solid-phase 13C NMR spectroscopy using the cross polarization with magic angle spinning (CP/MAS). Significant differences in the structure of polycondensed aromatic nuclei were revealed, and the ratio between the pericondensed and catacondensed cycles depending on the degree of coalification was assessed. Correlation analysis has been carried out and the relationships between various chemical technological parameters of coals and the indicators of their molecular structure were established. The strongest relationships have been revealed between the aromaticity factor of coals, the fraction of carbon in pericondensed structures, the yield of volatile substances and the reflectance of vitrinite. The identified features of the molecular structure of the organic coal matter and the obtained regression dependences can serve as the physicochemical basis when selecting coals for obtaining polycondensed aromatic substances for the production of carbon materials.
ЭВРИСТИЧЕСКИЙ ПОТЕНЦИАЛ ЗАКОНА ОТРИЦАНИЯ ОТРИЦАНИЯ В КОНТЕКСТЕ ЕГО ЗНАЧЕНИЯ ДЛЯ ПОНИМАНИЯ РАЗВИТИЯ НАУЧНОГО ЗНАНИЯ
Authors: КИРИЧЕК А.В. , ХОДИКОВА Н.А. 
Published: January 2025

В статье исследуются эвристические возможности закона отрицания отрицания и связанных с ним категорий для раскрытия закономерностей роста научного знания. На материале истории естествознания показано, что борьба альтернативных концепций может быть представлена сквозь призму этого закона в виде завершенных циклов перехода от исходного тезиса через несколько антитезисов к итоговому синтезу, который впоследствии может стать тезисом в рамках нового познавательного цикла. На основе проведенного анализа авторы формулируют рекомендации методологического характера, адресованные широкому кругу исследователей и нацеленные на повышение результативности любой творческой деятельности.
The article studies the heuristic capabilities of the law of the negation of negation and related categories for revealing the patterns of the growth of scientific knowledge. Based on the history of natural science, it is shown that the struggle of alternative concepts can be presented in the light of this law as completed cycles of transition from the initial thesis through several antitheses to the final synthesis, which can subsequently become a thesis within the framework of a new cognitive cycle. According to the conducted analysis, the authors formulate methodological recommendations addressed to a wide range of researchers and aimed at increasing the effectiveness of any creative activity.
Conflicting data and new ways of digitising Byzantine prosopography
Authors: Rózsa Márton 
Published: January 2025

AbstractThis paper aims to illustrate the abilities and practicability of digital prosopographical databases through the case of historical dates. Numerous historical databases were created in the last few decades, and they applied different models to record and store historical data in an effective way. Although the developers and researchers of these projects faced several problems due to a conflict between the characteristics of structured databases and the nature of historical evidence and historical studies. The paper compares the methodologies of two databases, PBW and RELEVEN through the cases of the death of John of Bari and Bisantius Guirdeliku. The primary sources provide conflicting dates of these events. Thus, the analysis can address the issues of interpretation and authority behind a piece of information.
Irish antiquity and ancient Greece: Standish O'Grady's History of Ireland
Authors: McAteer Michael 
Published: January 2025

AbstractPublished between 1878 and 1881, the three volumes of Standish O'Grady's History of Ireland comprise a narrative of Irish mythology, driven by the author's conviction that many of the ancient tales were rooted in actual history. Although not immediately felt, the impact of History of Ireland became long-lasting, a point of departure for an array of literary works treating Irish mythological topics during what came to be known as the Irish Literary Revival. This paper addresses History of Ireland from the perspective of O'Grady's background as a student of ancient Greek civilization. It considers the most important comparisons that he drew between Irish and Greek antiquity, including his contention that the seat of the High Kings of Ireland, Tara, was equivalent in symbolism to Mount Olympus in ancient Greece. The paper assesses the strengths, weaknesses and significance of O'Grady's case for considering Irish mythology as approximate to that of the Greeks.
Numerical analysis of low-velocity impact behavior on composite materials
Authors: Emad Alaa , Idan Muayad M. 
Published: January 2025

AbstractThis study uses numerical modeling to explore the intricate relationship between low-velocity impact and composite materials. The study investigates the impact response of composite materials under low-speed loading circumstances in great detail. Two specimens were prepared for the current study the first one has a uniform thickness for each layer, and the second is prepared with altering layer thicknesses. A tensile test was employed to obtain the mechanical properties to use it in the numerical analysis. An impact test was employed in this analysis, where the impactor was modeled also on a height of 300 mm, the analysis time was taken as 0.08 s to capture all the impact. The numerical analysis was verified with other studies, and the error percentage did not exceed 2%. The results showed that the second specimen with alternating thickness had the best behavior.
Rare Occurrence of Bastnaesite, Yttro-columbite and Chevkinite from Podili Granite, Prakasam Alkaline Province within Nellore Schist Belt, Southern India: Insights from Field, Petrography, Geochemistry and Mineral Chemistry
Authors: Biswas Ankita , Banothu Venkanna , Chandramouleeswara Rao K. 
Published: January 2025

ABSTRACT
This work reports the occurrence of Bastnaesite, Yttro-columbite, and Chevkinite for the first time from Podili alkali pluton, Andhra Pradesh. Podili granite is an A-type Mesoproterozoic alkali granite situated within the Prakasam Alkaline Province (PAP), emplaced within the Neoarchaean Nellore schist belt (NSB) towards its northern part. Petrography, SEM-EDS and Electron Probe Micro Analyser (EPMA) confirm the occurrence of bastnaesite [Ce, La (CO3) F] as discrete euhedral hexagonal crystal forming at the interstitial spaces of plagioclase feldspar at times, indicating its magmatic origin. Yttro-columbite [Y(Fe)Nb2O] occurs as inclusion within the zircon. Chevkinite [(Ce, Nd, Ca)4(Fe)2(Ti, Fe)3Si4O22] appear as euhedral grains disseminated in the feldspar-rich matrix. The presence of bastnaesite, yttro-columbite and chevkinite is responsible for the enrichment of ΣLREE (Max.1645ppm) over ΣHREE (Max.129ppm) in Podili syenite evolved through volatile enriched Podili alkali granite. Enrichment of fluorocarbonate bastnaesite indicates the presence of halogen F- in the melt, which substitutes hydroxyl ion (OH-) and facilitates late-stage REE mineral crystallisation. The halogen-bearing late-stage injection of CO2-rich melt affected the initial volatile enriched host alkali granite that evolved the granite and enriched the pluton with the LREE-dominated fluorocarbonate with significant REE mineral precipitation due to fluid-rock interactions.
Experimental Study on Multi-mode Control and Cascade Control of Electrohydraulic Shaking Table with Actuation Redundancy
Authors: Chai Weichao , Hu Xiao , Zhang Yanhong 
Published: January 2025

ABSTRACT
The electrohydraulic shaking table with actuation redundancy is widely used in the field of structural seismic and geohazard testing and research. To achieve more precise control of it, additional methods are required to suppress the internal force between actuators, building upon the six-degree of freedom (DOF) position control. This paper presents an analysis of two control methods: multi-mode control and cascade control. The high-performance electrohydraulic shaking table, equipped with eight actuators, serves as a case study. The multi-mode control approach introduces two distorted modes of the table to obtain a definitive solution for the actuator’s drive signals. By incorporating these modes, the internal force between actuators can be effectively mitigated. On the other hand, the cascade control method achieves control over the actuators’ force by incorporating eight inner loop force controllers. This approach has also proven effective in reducing the internal force between actuators. Analysis and experimental results demonstrate the efficacy of both methods in mitigating the internal force between actuators. Moreover, the cascade control method exhibits versatility and is not restricted by the number of actuators, making it a suitable choice for systems with more than eight actuators.
Escola pública municipal de Parintins - AM: o ensino e a prática de leitura literária em uma turma do 8º ano do Ensino Fundamental
Authors: Nascimento Dilce Pio , Castro Terciane Santos , Curvelo Heloísa Reis 
Published: January 2025

O universo literário é grandioso e vasto, é notório que não se pode apresentá-lo por completo em algumas poucas horas de aula, porém, no atual sistema educacional é visível a falta de incentivo quanto a leitura. O espaço dado a leitura é pequeno se compararmos com o espaço ordenado ao ensino da gramática, e quando estudada em sala de aula, os textos literários têm a função do ensino da gramática da Língua Portuguesa. Em nosso artigo objetivamos tratar sobre a realidade dos alunos que estão crescendo em uma sociedade com pouco incentivo à leitura de textos literários e menos acesso a livros, percebemos isso pelo baixo índice de leitores no Brasil de acordo com o Estudo Internacional de Progresso em Leitura – PIRLS (2023). Nossa pesquisa está pautado na pesquisa-ação e bibliográfica de abordagem qualitativa com enfoque dialético, na medida em que investigamos uma realidade social e o que intervém sobre ela, buscando analisar as práticas de incentivo à leitura em sala de aula frente às novas diretrizes educacionais propostas pela BNCC em uma escola pública de ensino fundamental em Parintins – AM, tendo como base teórica os estudos de Calvino (2002), Cosson (2014; 2020), Culler (1999), Freire (1989; 1992), Lajolo (2011), Todorov (2009) e Zilberman (1991). Dessa forma, mostraremos que a sala de aula, a escola e a família podem fazer com que as crianças e adolescentes despertem para a leitura, não apenas como uma exigência educacional para notabilizar os alunos, mas mostrar as vantagens que o hábito da leitura propicia.
Effect of Sowing Dates and Planting Densities on Yield and its Components of Three Varieties of Sesame (Sesamum indicum L.) in the Samangan Environment
Authors: Rabbani Barakatullah , Zaree Waliullah , Safdary Ali Jawed , Yaquby Abdul Maruf , Saddad Saifuddin 
Published: January 2025

Background: Sowing date and planting density are the main factors playing a prominent role in determining the yield of crops. Sowing date has the most significant impact on the phonological and growth characteristics of plants compared to other crop traits. On the other hand, in low planting densities, environmental facilities, including light, space, water and soil, are not optimally used, ultimately reducing yield. Sesame yield is highly variable depending upon the growing environment, cultural practices and cultivars. Methods: The study was planned to determine the effect of different sowing date (April 10th, May 10th and June 10th) and planting densities (20, 30 and 40 plants/m2) on three sesame varieties (Balkh, Baghlan and Samangan), during the 2022 and 2023 cropping seasons at the experimental field of Samangan University, Afghanistan. The experiments were conducted as split-plot factorial in randomized complete blocks design with three replications. Result: The results revealed significant effects of sowing date and plant density on all studied traits across both years. The highest seed yield (1.6 t/ha) was achieved with Balkh variety, sown on April 10th and a plant density of 40 plants/m2. Conversely, Baghlan variety, sown on June 10th, at 20 plants/m2, yielded the lowest (0.9 t/ha) in 2022. The study underscores the importance of sowing date and plant density in optimizing sesame yield. Early sowing (April 10th) and higher plant density (40 plants/m2) were associated with superior seed productivity, highlighting their significance for sesame cultivation in the region.
OBJEKAT KANTOVOG KATEGORIČKOG IMPERATIVA
Authors: ĐURĐEVIĆ SRĐAN 
Published: January 2025

Kant predlaže strogu metodologiju sa ciljem razlikovanja između „kategoričkog imperativa“ moralnog zakona i „hipotetičkog“ imperativa posrednih ciljeva. Zadatak jeste pronaći Dobro, očistiti moralni zakon od svega „patološkog“, tj. isključiti sve ono što u subjektu izaziva interesovanje za konkretan objekat – bilo nagon, ili osećanje. Svesti ga na čistu formu. Lakan de Sadovo delo Filozofija u budoaru posmatra kao otkrivanje Kantovog objekta moralnog Zakona koji je, mada ga sam Kant kategorički odbija, implicitno nužno prisutan. Markiz de Sad je Kantova istina time što obelodanjuje objekat Zakona, ovaploćen u vidu egzekutora, mučitelja koji nad svojim žrtvama izvršava sadističke radnje. U njemu nema ničeg vezanog za zadovoljstvo. On obavlja radnje u skladu sa dužnošću, te su one u kantovskom smislu etičke. Kantovski subjekat jeste sam svoj praktički zakonodavac, moralni subjekt koji odgovara na zov dužnosti, prikrivajući rascepljenost subjekta izjavljivanja kategoričkog imperativa u odnosu na moralni subjekt izjave. Lakan upravo ukazuje na svojevrsno maskiranje rascepa, pozivajući se na shemu analognu shemi razvojnog stukturisanja subjekta, na subjekta izjave i subjekta izjavljivanja. Egzekutor izvršava tuđu volju, volju Drugog, tako da sam sadista i njegove radnje nemaju za cilj užitak. „Mučitelj“ se mazohistički potčinjava volji Drugog, što vodi instrumentalizaciji njegove pozicije, odnosno mučeći žrtvu, on se odriče sebe zarad Drugog.
SRBSKÉ ĽUDOVÉ PRÍSLOVIA S LEXÉMOU БРАТ/БРАЋА (BRAT/BRATIA) A ICH DERIVÁTMI
Authors: Chalupová Nina J. 
Published: January 2025

Predložený príspevok má lingvokulturologický charakter. Predmetom tohto príspevku je fond srbských ľudových prísloví s lexikálnym motivantom брат/браћа (brat/bratia) a jeho derivátmi, ktorých zbierku urobil V. Stefanović Karadžić. Pozornosť venujeme aj definíciám prísloví a lexiky, ako i otázke, akú úlohu zohráva jazyk v kultúre. Sústreďujeme sa aj na významy lexémy брат (brat) v slovníku Речник српскога језика a na údaje o lexéme брат (brat) v slovníku Обратни асоцијативни речник српскога језика. Cieľom práce je aplikovať opisnú metódu, aby sme získali nové poznatky o srbských ľudových prísloviach. V práci sa zaoberáme analýzou srbských ľudových prísloví s lexémou брат/браћа (brat/bratia) a ich derivátmi a zisťujeme, že príslovia vyjadrujúce kladný význam sa vyskytujú v práci v rovnakom počte ako príslovia, ktoré majú negatívnu konotáciu. Brat sa chápe v srbskej kultúre ako ambivalentný pojem. Východiskovou literatúrou boli príspevky R. Dragićevićovej, J. Dražićovej, J. Jovanovićovej Simićovej atď.
Perioperative Management, Complications, and Outcomes of Shoulder Arthroplasty in Patients with Diabetes Mellitus
Authors: Viqueira Marissa , Stadler Ryan D. , Sudah Suleiman Y. , Calem Daniel B. , Manzi Joseph E. , Lohre Ryan , Elhassan Bassam T. , Menendez Mariano E. 
Published: January 2025

» Patients with diabetes mellitus (DM) undergoing shoulder arthroplasty (SA) have a unique risk profile, which must be considered by clinicians.» The presence of DM as a comorbidity is associated with longer length of stay following SA, greater likelihood of nonhome discharge, and a higher rate of 90-day readmission.» Though the incidence is low, patients with DM are at an increased risk of serious postoperative cardiovascular complications, such as pulmonary embolism, venous thromboembolism, and myocardial infarction.» DM has generally been associated with increased risk of postoperative infection. The optimal hemoglobin A1c threshold in patients undergoing SA remains inconclusive. When extrapolating from lower limb arthroplasty, the literature indicates that this threshold is most likely in the range of 7.5% to 8%.» Patients with DM are more likely to require revision surgery after SA and report lower postoperative satisfaction.
RNA translational regulation by CPEB4 orchestrates platelet function and pathophysiology
Authors: Navarro Pilar , Hurtado Begoña , Gibert Joan , Vázquez-Bellón Núria , Aresté Cristina , Sánchez-Belmonte Agustín , Ximénez-Embún Pilar , Martínez-Bosch Neus , Muñoz Javier , Tàssies Dolors , Reverter Joan Carles , Morales Albert , Méndez Raúl , Malumbres Marcos , de Frutos Pablo García 
Published: January 2025

Abstract

Platelets are highly specialized anucleate cells that play crucial roles in haemostasis, inflammation and disease. Recent data suggest that mRNA translational control is the primary mechanism of gene regulation in platelets. This study unveils a novel pathway to control mRNA translation and protein expression in platelets via the mRNA binding protein CPEB4. We found high CPEB4 expression levels in human and mouse platelets, colocalizing with cytoskeletal proteins. In vivo loss-of-function studies, using the megakaryocytic lineage-specific Pf4-Cre transgenic mice crossed with a strain containing loxP-flanked CPEB4 (Pf4+:Cpeb4–/– mice), revealed a significant reduction of platelet activation and aggregation. These effects were specific to mature platelets, as CPEB4 deficiency did not significantly impact megakaryocytopoiesis. Functional assays, including tail bleeding and collagen-induced embolism, demonstrated impaired coagulation in Pf4+:Cpeb4–/– mice compared to controls. Furthermore, proteomics analysis of resting and activated platelets from Pf4–:Cpeb4+/+ and Pf4+:Cpeb4–/– mice identified a molecular signature of proteins and networks regulated by CPEB4, including those involved in haemostasis and platelet clearance. Our study reveals CPEB4-mediated mRNA translational regulation as a novel fine-tuning mechanism for modulating protein synthesis in platelets, with significant functional consequences in both physiological and pathological conditions.