bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why talk about sin? Luther's understanding of sin and hopeful sin‐talk in the 21st century
Authors: Guðmundsdóttir Arnfríður 
Published: August 2023

AbstractFor Luther talking about sin and the sinful nature of human beings has a strong pastoral significance. His emphasis on the “bondage” of the human will is tightly connected to his insistence on the human sinful condition, and our inability to choose to be or not to be held captive by sin. My conclusion is that it is indeed important to continue to talk about sin if the Christian discourse about God's forgiveness and grace is to make sense. Furthermore, I believe Luther's understanding of sin as misplaced trust, the distinction he makes between sin and sins, and his idea of a justified sinner can indeed make a significant contribution to a hopeful sin‐talk within Christian communities today. It is, however, necessary to pay attention to Luther's historical context and to reevaluate his understanding of human nature and human sinfulness from a feminist critical perspective.The sin‐concept has gradually been losing its relevance within Christian communities. Therefore the question: why should we continue to talk about sin? The aim of this article is to explore Luther's understanding of sin and human sinfulness, in order to find out if, and then how, he might prove helpful when it comes to the interpretation of the concept of sin in the 21st century. The focus is on Luther's pastoral writings in The Small and The Large Catechism (1529), together with his Smalcald Articles (1537).
Identification of factors associated with progression of left atrial enlargement in patients with atrial fibrillation
Authors: Uemura Koya , Nishimori Makoto , Nagai Shun , Takeuchi Mariko , Nishihara Yu , Todo Saki , Oota Eri , Odajima Susumu , Takeuchi Kimikazu , Ichikawa Yasushi , Kintsu Masayuki , Yamauchi Yuki , Shiraki Hiroaki , Yamashita Kentaro , Fukuda Terunobu , Hisamatsu Eriko , Hirata Ken‐ichi , Tanaka Hidekazu 
Published: August 2023

AbstractLeft atrial (LA) enlargement frequently occurs in atrial fibrillation (AF) patients, and this enlargement is associated with the development of heart failure, thromboembolism, or atrial functional mitral regurgitation (AFMR). AF patients can develop LA enlargement over time, but its progression depends on the individual. So far, the factors that cause progressive LA enlargement in AF patients have thus not been elucidated, so that the aim of this study was to identify the factors associated with the progression of LA enlargement in AF patients. We studied 100 patients with persistent or permanent AF (aged: 67 ± 2 years, 40 females). Echocardiography was performed at baseline and 12 (5–30) months after follow‐up. LA size was evaluated as the LA volume index which was calculated with the biplane modified Simpson's method from apical four‐and two‐chamber views, and then normalized to the body surface area (LAVI). The deterioration of AFMR after follow‐up was defined as a deterioration in severity of mitral regurgitation (MR) by a grade of 1 or more. Multivariate regression analysis demonstrated that hypertension (p = .03) was an independently associated parameter of progressive LA enlargement, as was baseline LAVI. In addition, the Kaplan–Meier curve indicated that patients with hypertension tended to show greater deterioration of AFMR after follow‐up than those without hypertension (log‐rank p = .08). Hypertension proved to be strongly associated with progression of LA enlargement over time in patients with AF. Our findings provide new insights for better management of patients with AF to prevent the development of AFMR.
Latitude‐specific urbanization effects on life history traits in the damselfly Ischnura elegans
Authors: Palomar Gemma , Wos Guillaume , Stoks Robby , Sniegula Szymon 
Published: August 2023

AbstractMany species are currently adapting to cities at different latitudes. Adaptation to urbanization may require eco‐evolutionary changes in response to temperature and invasive species that may differ between latitudes. Here, we studied single and combined effects of increased temperatures and an invasive alien predator on the phenotypic response of replicated urban and rural populations of the damselfly Ischnura elegans and contrasted these between central and high latitudes. Adult females were collected in rural and urban ponds at central and high latitudes. Their larvae were exposed to temperature treatments (current [20°C], mild warming [24°C], and heat wave [28°C; for high latitude only]) crossed with the presence or absence of chemical cues released by the spiny‐cheek crayfish (Faxonius limosus), only present at the central latitude. We measured treatment effects on larval development time, mass, and growth rate. Urbanization type affected all life history traits, yet these responses were often dependent on latitude, temperature, and sex. Mild warming decreased mass in rural and increased growth rate in urban populations. The effects of urbanization type on mass were latitude‐dependent, with central‐latitude populations having a greater phenotypic difference. Urbanization type effects were sex‐specific with urban males being lighter and having a lower growth rate than rural males. At the current temperature and mild warming, the predator cue reduced the growth rate, and this independently of urbanization type and latitude of origin. This pattern was reversed during a heat wave in high‐latitude damselflies. Our results highlight the context‐dependency of evolutionary and plastic responses to urbanization, and caution for generalizing how populations respond to cities based on populations at a single latitude.
Text‐centered “talk” in foreign language classrooms: Comparing the affordances of face‐to‐face and digital social annotated reading
Authors: Michelson Kristen , Abdennebi Mourad , Michelson Chuck 
Published: August 2023

AbstractThis quasi‐experimental study compares text‐centered dialogs between two groups of intermediate second language (L2) French learners: traditional face‐to‐face (FTF) discussion groups; and groups who annotated and discussed texts through the digital social annotated reading (DSAR) platform,Hypothes.is. All participants read the same articles, with discussions guided by the same reading questions. Participants' dialogs in both conditions were coded based on types of discursive moves, then analyzed through a framework of social, textual, and linguistic affordances. Findings revealed that social affordances emerged significantly more frequently than other affordances among FTF groups while textual affordances emerged significantly more frequently than other affordances among DSAR groups. Findings support the benefits of DSAR tools for more anchored discussions over traditional FTF classroom discussions, with the caution that DSAR tools alone do not necessarily promote deep discussion of foreign language texts. Beyond pedagogical implications, this study suggests an expansion of theoretical frameworks of affordances in future DSAR research.
Cisnormative symbolic colonization and transgender and gender nonconforming individuals in the workplace
Authors: Anderson Karoline Anita 
Published: August 2023

AbstractCisnormativity assumes individual traits and social roles that correspond to one's gender assigned at birth. Cisnormativity in workplace culture sustains the discrimination of transgender and gender nonconforming (TGNC) individuals. Research in the workplace has yet to evaluate strategies that TGNC employees use to attain personal or social goals. In the present study, the term cisnormative symbolic colonization (CSC) incorporates Habermas' theory of communicative action with symbolic interactionism to demonstrate the permeation of cisnormative dominance in workplace culture through symbolic social practices. Interviews with 15 transgender women and gender nonconforming individuals illustrated four strategies used to mitigate CSC in the workplace: bargaining, validating, symbolic‐aligning, and value‐endorsing. The findings demonstrated the dominant impact of CSC in workplace culture and revealed the employment of trans‐symbolism to integrate trans‐inclusive values in the workplace.
Facilitating healthcare dieticians' communication skills: A reflective practice intervention
Authors: Picknell Gareth , Cropley Brendan , Mellalieu Stephen , Hanton Sheldon 
Published: August 2023

AbstractReflective practice (RP) is a widely accepted approach for facilitating experiential learning within the professional development of service delivery practitioners. However, a dearth of empirical evidence exists to support the potential efficacy of RP for improving applied practice effectiveness. This study examined whether improving professionals' ability to engage in RP at more advanced critical levels impacted their use of communication skills (CS) in practice. A quasi‐experimental, multiple‐baseline, crossover design was employed with 20 Emirati female dieticians who were assigned to one of two groups and exposed to three RP treatments and three control periods. Baseline and postintervention measures of RP and CS were administered to assess whether improved RP skills subsequently impacted practice behaviours. A significant difference between experimental and control groups' RP scores were reported over the treatment period. For CS there was an intervention effect for: listening and rapport; questioning skills; comprehensiveness; organization; transitional statements; and approach to planning and education. The findings indicate that the intervention was successful for improving participants' reflective skills, resulting in more favourable practice behaviours (e.g., CS). This study makes a novel contribution to the literature by providing rigorous empirical evidence to support the value of RP as a metacognitive strategy for improving service delivery behaviours in health professionals.
Evaluation of sexual function after robot‐assisted radical prostatectomy: A farewell toIIEFquestionnaire
Authors: Shiraishi Koji 
Published: August 2023

AbstractLongevity with localized prostate cancer (PCa) has been achieved, and the contribution of robot‐assisted radical prostatectomy (RARP) to cancer control is evident. The next step to investigate in the treatment of localized PCa is improvement of the quality of life (QOL) after RARP. Erectile dysfunction has been considered a major surgical complication, and patient satisfaction after RARP has not improved despite the development of nerve preservation and penile rehabilitation. To comprehensively understand sexual dysfunction after RARP, we must investigate other complications with regard to sexual health, including low sexual desire, disturbed orgasmic function (i.e., anejaculation, orgasm intensity, painful orgasm, and climacturia), shortening of penile length, penile curvature (Peyronie's disease) and unique psychological alterations after the diagnosis of PCa, which are neglected side effects after prostatectomy. In this context, routine evaluation of erectile function by the International Index of Erectile Function only is not sufficient to understand patients' difficulties. A questionnaire is just one way of enabling patients to evaluate their pre‐ and postoperative concerns; listening to patients face‐to‐face is warranted to detect symptoms. Understanding the relationship between symptoms and preserved nerve localization can ultimately provide an individualized nerve‐sparing procedure and improve patient satisfaction after RARP. In combination with psychological counseling, including the partner and medical treatment, such as testosterone replacement, it is time to reconsider ways to improve sexual dysfunction after RARP.
Deubiquitinase inhibitor PR‐619 potentiates colon cancer immunotherapy by inducing ferroptosis
Authors: Wu Jingjing , Liu Chang , Wang Tao , Liu Hua , Wei Bin 
Published: August 2023

AbstractA substantial number of colon cancer patients do not benefit from immunotherapy using programmed cell death 1 (PD1) antibodies. Therefore, combination therapy drugs are required to improve the efficacy of colon cancer immunotherapy. Recent studies have shown that deubiquitinases are negative regulators of anti‐tumour immunity. In the present study, we investigated the effect of the deubiquitinase inhibitor PR‐619 in combination with anti‐PD1 for the treatment of colorectal cancer. The results revealed that co‐treatment with PR‐619 and anti‐PD1 significantly inhibited tumour growth in tumour‐bearing BALB/c mice compared to monotherapy with a single drug. In addition, PR‐619/anti‐PD1 combined therapy inhibited cell proliferation, promoted cell apoptosis, induced intratumor infiltration of CD8+ T cells, and enhanced the release of anti‐tumour cytokines. Moreover, PR‐619 induced ferroptosis in colon cancer cells, thereby inducing the release of damage‐associated molecular patterns that triggered anti‐tumour immunity. Finally, we discovered that PR‐619 could degrade the GPX4 protein, the high expression of which was associated with poor prognosis and blocked CD8+ T cells infiltration in colon cancer. In conclusion, PR‐619 may potentiate immunotherapy by inducing ferroptosis, and thereby promoting CD8+ T cells‐mediated anti‐tumour immunity, providing a potential strategy for colon cancer treatment.
Roles and competencies of nurses and physicians in shared decision‐making in cardiac surgery: A scoping review
Authors: van Dieën Milou S. H. , Paans Wolter , Mariani Massimo A. , Dieperink Willem , Blokzijl Fredrike 
Published: August 2023

AbstractAimIdentification and synthesis of research data related to the roles and competencies of physicians and nurses that are prerequisites for careful shared decision‐making with patients potentially undergoing cardiac surgery.DesignA scoping review was conducted in accordance with the Joanna Briggs Institute's methodology for scoping reviews and the PRISMA Extension for Scoping Reviews.MethodsPubMed, EMBASE and CINAHL were searched from inception dates up to March 2022, to identify primary studies published in a peer‐reviewed journal. Study selection, assessment of the methodological quality and data extracting of the included studies were done by at least two independent researchers. To describe the findings of the studies, an emergent synthesis approach was used to visualize a descriptive representation of professional roles and competencies in shared decision‐making, in an overview.ResultsThe systematic search revealed 10,055 potential papers, 8873 articles were screened on title and abstract and 76 full texts were retrieved. Eight articles were included for final evaluation. For nurses and physicians, 26 different skills were identified in the literature to practice shared decision‐making in cardiac surgery. The skills that emerged were divided into five professional roles: moderator; health educator; data collector; psychological supporter and translator.ConclusionsThis review specifies the professional roles and required competencies related to shared decision‐making in cardiac surgery. Further research is needed to compare our findings with other clinical areas and from there to arrive at a professional division of roles between the different clinical disciplines involved.ImpactThe visualization of generic shared decision‐making competencies and roles should establish the professional division of positions between various clinical physician and nurse disciplines in order to create a treatment plan based on evidence, values, preferences and the patient's personal situation.Patient or Public ContributionNo patient or public contribution.
Radiological assessment of immunotherapy effects and immune checkpoint‐related pneumonitis for lung cancer
Authors: Hu Qiongjie , Wang Shaofang , Ma Li , Sun Ziyan , Liu Zilin , Deng Shuang , Zhou Jianlin 
Published: August 2023

AbstractImmune checkpoint inhibitors (ICIs) therapy have revolutionized advanced lung cancer care. Interestingly, the host responses for patients received ICIs therapy are distinguishing from those with cytotoxic drugs, showing potential initial transient worsening of disease burden, pseudoprogression and delayed time to treatment response. Thus, a new imaging criterion to evaluate the response for immunotherapy should be developed. ICIs treatment is associated with unique adverse events, including potential life‐threatening immune checkpoint inhibitor‐related pneumonitis (ICI‐pneumonitis) if treated patients are not managed promptly. Currently, the diagnosis and clinical management of ICI‐pneumonitis remain challenging. As the clinical manifestation is often nonspecific, computed tomography (CT) scan and X‐ray films play important roles in diagnosis and triage. This article reviews the complications of immunotherapy in lung cancer and illustrates various radiologic patterns of ICI‐pneumonitis. Additionally, it is tried to differentiate ICI‐pneumonitis from other pulmonary pathologies common to lung cancer such as radiation pneumonitis, bacterial pneumonia and coronavirus disease of 2019 (COVID‐19) infection in recent months. Maybe it is challenging to distinguish radiologically but clinical presentation may help.
Determining the instantaneous bruising pattern in a sample potato tuber subjected to pendulum bob impact through finite element analysis
Authors: Celik H. Kursat , Akinci Ibrahim , Erkan Mustafa , Rennie Allan E. W. 
Published: August 2023

AbstractPotato bruising resulting from mechanical impact during production operations including harvest and postharvest is a significant concern within the potato production sector, leading to consumer complaints and economic losses. The detection of instantaneous internal bruising poses a particular challenge as it can progress over time during storage or transportation, making it difficult to identify immediately after external impact. This study aims to investigate the progression of bruising and accurately represent the instantaneous dynamic deformation behavior of potato tubers under four pendulum bob impact cases (pendulum arm angles of 30°, 45°, 60°, and 90°). To analyze the dynamic impact deformation characteristics of the tubers, solid modeling based on a reverse engineering approach and explicit dynamic engineering simulations were employed. The simulation results yielded valuable numerical data and visual representation of the deformation progression. The loading conditions considered in this study indicated that the maximum stress values, reaching 0.818 MPa at a pendulum arm angle of 90°, remained below the bio‐yield stress point of the tuber flesh (1.05 MPa) determined through experimental compression tests. Therefore, it was concluded that the impact did not cause permanent deformation (i.e., permanent bruising) in the tuber. However, the numerical analysis clearly demonstrated the sequence of stress occurrences, which is a key contributing factor to potential permanent bruising. In this regard, the bruising energy threshold of 318.314 mJ (R2: 0.96) was extrapolated. The numerical findings presented in this study can aid in evaluating the susceptibility of tuber samples to bruising. By employing nonlinear explicit dynamics simulations, this research contributes to the advancement of understanding complex deformation and bruising in solid agricultural products. Moreover, the application of these techniques holds significant industrial implications for enhancing the handling and transportation of agricultural produce.Practical applicationsThis research aims to tackle the challenge of accurately representing the immediate internal bruising pattern in potato tubers resulting from mechanical impact. Conventional methods, such as physical or analytical expressions, may not fully capture the distribution of bruising experienced by the tubers. To overcome this limitation, an engineering simulation approach is proposed to provide a more precise depiction of the instantaneous bruising pattern. By advancing the understanding of complex deformation and bruising in solid agricultural products, this research contributes to improving the efficiency and quality of agricultural production in the industry. Additionally, this study offers a step‐by‐step guide on how to conduct these simulations effectively.
Investor Tax Credits and Entrepreneurship: Evidence from U.S. States
Authors: DENES MATTHEW , HOWELL SABRINA T. , MEZZANOTTI FILIPPO , WANG XINXIN , XU TING 
Published: August 2023

ABSTRACTAngel investor tax credits are used globally to spur high‐growth entrepreneurship. Exploiting their staggered implementation in 31 U.S. states, we find that they increase angel investment yet have no significant impact on entrepreneurial activity. Two mechanisms explain these results: crowding out of alternative financing and low sensitivity of professional investors to tax credits. With a large‐scale survey and a stylized model, we show that low responsiveness among professional angels may reflect the fat‐tailed return distributions that characterize high‐growth startups. The results contrast with evidence that direct subsidies to firms have positive effects, raising concerns about promoting entrepreneurship with investor subsidies.
Current perspectives on endometrial receptivity: A comprehensive overview of etiology and treatment
Authors: Hiraoka Takehiro , Osuga Yutaka , Hirota Yasushi 
Published: August 2023

AbstractRecurrent implantation failure (RIF) remains a challenging problem in assisted reproductive technology (ART). Further insights into uterine abnormalities that can disturb embryo implantation should be obtained. This review provides an overview of the effects of organic and non‐organic uterine disorders on endometrial receptivity. The results suggest that various uterine pathologies can lead to defective embryo implantation via multiple mechanisms. In particular, uterine adenomyosis dysregulates molecular and cellular interactions that are vital for successful embryo implantation with a background of chronic inflammation, which may be alleviated by pretreatment with a gonadotropin‐releasing hormone agonist. Uterine myomas can cause endometrial deformation and adverse alterations in uterine contractility. Nonetheless, the effectiveness of myomectomy remains debated, and endometrial polyp removal may be considered, particularly in patients with RIF. Chronic endometritis abrogates the appropriate uterine immunological environment critical for embryo implantation. Abnormal endometrial microbiota have been suggested to influence endometrial receptivity; however, supporting evidence is currently scarce. Platelet‐rich plasma therapy may be a potential treatment for thin endometria; nevertheless, further validation is required. Endometrial receptivity analysis can detect dysregulation of the window of implantation, and new non‐invasive methods for predicting endometrial receptivity have recently been proposed. However, numerous issues still need to be fully clarified. Further clinical and basic studies are necessary to investigate the pathophysiology of defective endometrial receptivity and identify optimal treatments for patients undergoing ART, especially those with RIF.
Heroes or Villains? Recasting Middle Management Roles, Processes, and Behaviours
Authors: Tarakci Murat , Heyden Mariano L. M. , Rouleau Linda , Raes Anneloes , Floyd Steven W. 
Published: August 2023

AbstractMiddle management ranks are once again being questioned by scholars and practitioners alike. This introduction to the special issue represents a timely reference point for consolidating, reviving, and guiding the next wave of researchers seeking to engage this debate. We review the foundations and recent advances in middle management research and develop an organizing framework in terms of middle management's organizational roles, coordination processes, and agentic behaviours. We also identify how new ways of organizing, technology, and middle manager needs are changing to shape each of these themes. The collection of works we synthesize in this introduction offer theoretical advances and empirical evidence on how these changes affect middle management roles, processes, and behaviours. We conclude by mapping out promising research avenues for future research in middle management.