bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evolutionary and genetic patterns of African swine fever virus
Authors: Cho Myeongji , Min Xianglan , Been Nara , Son Hyeon S. 
Published: September 2023

Abstract

Background: African swine fever (ASF) is a serious animal disease, and has spread to Africa, Europe and Asia, causing massive economic losses. African swine fever virus (ASFV) is transmitted from a reservoir host (warthog) to domestic pigs via a sylvatic cycle (transmission between warthogs and soft ticks) and a domestic cycle (transmission between domestic pigs) and survives by expressing a variety of genes related to virus–host interactions.
Methods: We evaluated differences in codon usage patterns among ASFV genotypes and clades and explored the common and specific evolutionary and genetic characteristics of ASFV sequences. We analysed the evolutionary relationships, nucleotide compositions, codon usage patterns, selection pressures (mutational pressure and natural selection) and viral adaptation to host codon usage based on the coding sequences (CDS) of key functional genes of ASFV.
Results: AT bias was detected in the six genes analysed, irrespective of clade. The AT bias of genes (A224L, A179L, EP153R) encoding proteins involved in interaction with host cells after infection was high; among them, the AT bias of EP153R was the greatest at 78.3%. A large number of overrepresented codons were identified in EP153R, whereas there were no overrepresented codons with a relative synonymous codon usage (RSCU) value of ≥ 3 in B646L. In most genes, the pattern of selection pressure was similar for each clade, but in EP153R, diverse patterns of selection pressure were captured within the same clade and genotype. As a result of evaluating host adaptation based on the codon adaptation index (CAI), for B646L, E183L, CP204Land A179L, the codon usage patterns in all sequences were more similar to tick than domestic pig or wild boar. However, EP153R showed the lowest average CAI value of 0.52 when selecting tick as a reference set.
Conclusions: The genes analysed in this study showed different magnitudes of selection pressure at the clade and genotype levels, which is likely to be related to the function of the encoded proteins and may determine key evolutionary traits of viruses, such as the level of genetic variation and host range. The diversity of codon adaptations at the genetic level in ASFV may account for differences in translational selection in ASFV hosts and provides insight into viral host adaptation and co‑evolution.
Self-eating in the plaque: nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis
Authors: ZHONG YUAN , Maruf Ali , Qu Kai , Milewska Małgorzata , Wandzik Ilona , Mou Nianlian , Cao Yu , Wu Wei 
Published: September 2023

Abstract
Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which is a leading cause of vascular diseases. During the progression of atherosclerosis, the autophagic function is impaired, resulting in lipid accumulation-mediated foam cell formation. The stimulation of autophagy is crucial for the recovery of cellular recycling process. One of the potential autophagy inducers is trehalose, a naturally occurring non-reducing disaccharide. However, trehalose has poor bioavailability due to its hydrophilic nature which results in poor penetration through cell membranes. To enhance its bioavailability, we developed trehalose-releasing nanogels (TNG) for the treatment of atherosclerosis. The nanogels were fabricated through copolymerization of 6-O-acryloyl-trehalose with the selected acrylamide-type monomers affording a high trehalose conjugation (~58%, w/w). TNG showed a relatively small hydrodynamic diameter (dH, 67 nm) and a uniform spherical shape and were characterized by negative zeta (ζ) potential (-18 mV). In vitro study confirmed that TNG could stimulate autophagy in foam cells and enhance lipid efflux and in vivo study in ApoE-/- mice indicated a significant reduction in atherosclerotic plaques, while increasing autophagic markers. In conclusion, TNG hold great promise as a trehalose delivery system to restore impaired autophagy-mediated lipid efflux in atherosclerosis and subsequently reduce atherosclerotic plaques.
Purpureocillium lilacinum, a biocontrol agent: Bioprospecting of its antagonistic activity against pathogenic Sporothrix spp
Authors: Corrêa-Moreira Danielly , Costa Gisela , Pereira Sandro , Almeida Adilson , Laine Roberta , Teixeira Claudener , Borba Cintia , Oliveira Manoel 
Published: September 2023

Abstract
Background
Purpureocillium lilacinum is a filamentous, hyaline, anamorphic and ubiquitous fungus described by some authors as biocontrol agent. The genera Sporothrix consists of 8 dimorphic pathogenic species, classically found in the soil, including in the Atlantic Forest. In the last years, there was an increase of studies about Sporothrix spp., however, few of them describing or attempting to isolate these fungi from the soil in Brazil. Previous studies of our group demonstrated that P. lilacinum was able to inhibit the growth of S. brasiliensis and to interact as overgrowth by antagonist pattern in vitro. Thus, the aim of this work was evaluating the antagonistic activity of P. lilacinum isolates against seven pathogenic Sporothrix spp. by dual culture method.
Results
Our results confirm the greater number of P. lilacinum isolates from soil in an area belonging to the sporotrichosis belt in Rio de Janeiro, Brazil, as well as the antagonistic activity against pathogenic Sporothrix spp.
Conclusions
Our study reinforces the need to better study the secondary metabolites produced by P. lilacinum. in the sense to improve its potential of being used as biocontrol agent. Additionally, these compounds may represent a good strategy for the control and treatment of emerging pathogenic fungi in the future.
Non-market values of urban parks in developing countries: The case of Samanes park
Authors: Zambrano-Monserrate Manuel A. , Ruano Maria Alejandra 
Published: September 2023

Abstract

Samanes Park is the largest urban park in Ecuador and the third in Latin America. The park is one of the country's protected areas, home to many native and wild species and a recreation space for local and foreign tourists. On the other hand, being a non-excludable non-rival good, SamanesPark is a public good. Many public goods do not have a market; consequently, they cannot be priced. The problem with the above is that they are not incorporated into decision-making, leading to their deterioration over time, the Samanes Park being an example of the above. However, the population demands this type of goods, and its value is reflected in the consumer surplus. Non-market valuation aims to estimate the consumer surplus of public goods. This surplus can be used as a reference for public policy projects that aim to preserve the resource. This research applies the travel cost method (indirect valuation method) to estimate the consumer surplus of site visitors. The consumer surplus was estimated at US$4.50 per visit (per individual). Finally, the results indicate that Samanes park can be considered an inferior good for certain visitors. This finding is novel and contradicts the neoclassical theory that the higher the population's income, the greater the demand for environmental goods and services.
Mediterranean diet adherence and glycemic control in children and adolescents with type 1 diabetes
Authors: Rebollo-Román Ángel , Tabernero-Urbieta Carmen , Rodríguez Joaquín Villaécija , Salas Bárbara Luque 
Published: September 2023

Abstract
Purpose: To effectively manage type 1 diabetes (T1D) insulin is essential, with dosages based on lifestyle. Mediterranean diet has demonstrated its advantages in preventing and enhancing the management of chronic diseases. Nevertheless, the evidence supporting this association in younger patients with type 1 diabetes remains limited. Our objective was to investigate the potential mediation of sensor activity on the relationship between adherence to the Mediterranean diet and glycemic control in children and adolescents.
Methods: 150 children and adolescents (mean age = 13.09, SD = 3.54; 44% female) with type 1 diabetes were recruited. Adherence to the Mediterranean diet was assessed using the KIDMED questionnaire. Glycemic control and the duration of sensor activity were evaluated based on data from flash glucose monitoring.
Results: The data confirmed our hypothesis by revealing a significant relationship between adherence to the Mediterranean diet and glycemic control. This relationship was mediated by the duration of sensor activity.
Conclusions: Our results highlight the importance of incorporating Mediterranean diet recommendations to achieve better glycemic control. Furthermore, our findings support the increased utilization of glycemic control devices, as they contribute to improve glycemic control and mediate on the positive relationship between adherence of Mediterranean diet and adequate glycemic control.
The prevalence and risk factors of sexual dysfunction in the elderly in parts of China
Authors: Wang Chen , Yu Zhenzhen 
Published: September 2023

Abstract
Objective
This study aims to evaluate the epidemiological features of sexual dysfunc -tion in the old people that ages more than 65 in parts of China, and to investigate the independent significant risk factors.
Methods
According to population distribution of five communities in Xiamen and Chongqing, we have enrolled 2403 people that ages more than 65 randomly. We collected data information thought questionnaire survey mainly. Then demonstrated the current condition of sexual dysfunction in the samples by statistical analysis, and multivariable logistic regression was used to disclosed the risk factors of sexual dysfunction in the older adults.
Results
This epidemiological investigation demonstrated that about 10.48 percent of the elderly suffering from sexual dysfunction in different degree and duration time, the prevalence rate of this study was lower than previous studies. Gender, living in region, education experience, BMI, smoking and drinking history, hypertension and depression were significant differences in the rate or median(all p༜0.05).and Living in urban region[OR = 4.142 OR95%CI: 1.745–5.739 p༜0.001],drinking history [OR = 1.711 OR95%CI:1.124–2.604 p = 0.012] and depression[OR = 2.107 OR95% CI:1.109–4.356 p = 0.044] were independent risk factors for the sexual function.
Conclusion
The prevalence of sexual dysfunction was low among the elderly in the parts of China. The old people of living in urban region, drinking and depression are more likely have prone to sexual dysfunction.
An Industrial Network Intrusion Detection Algorithm Based on IGWO-GRU
Authors: yang wei , shan yao , wang jiaxuan , yao yu 
Published: September 2023

Abstract
Nowadays, the industrial control system has become open and interconnected, and informatization also increases the risk of network attacks and damage due to frequent intrusion. Research on industrial intrusion detection is ongoing, but many current methods need to consider the characteristics of industrial control flow. Therefore, this paper proposes an industrial network intrusion detection algorithm based on IGWO-GRU: starting from the timing of industrial control network traffic, select the simple architecture of the gated recurrent unit (GRU) as the network model; in view of the problem of the number of network parameters such as neurons and the learning rate, the Grey Wolf Optimizer (GWO) is integrated with conducting autonomous learning to find the optimal parameters of the model and solve the problem of slow convergence rate caused by a large amount of data volume of the industrial control network traffic. However, due to the slow convergence speed and low optimization accuracy of the GWO algorithm and data imbalance, this paper improves an improved grey Wolf optimization algorithm (IGWO) by improving the nonlinear convergence factor and weight adjustment strategy to increase the convergence rate of the algorithm further and avoid falling into the local optimal solution. With the data set of the natural gas pipeline control system, the intrusion detection system is simulated for classifying abnormal flow attacks. The experimental results show that the IGWO-GRU algorithm has obvious advantages in accuracy, false alarm rate, and false report rate, which improves the safety protection ability of industrial control systems.
Income inequality, top shares of income and social classes in the 21st century
Authors: Giangregorio Luca , Villani Davide 
Published: September 2023

Abstract
This paper aims at providing new evidence about the link between personal and functional distribution and top-shares composition. We apply a novel class scheme based on two key features of contemporary capitalism i.e., individuals/households receiving multiple types of incomes, and the role of managers. The empirical application in Germany, Spain, and Italy over the period 2000–2017 reveals two main results. First, we observe a direct link between personal and functional distributions. In particular, a marginal increase in wages received by labourers would reduce inequality, whereas those received by capitalist households would increasing it. Second, we find that a significant portion of labour income at the top of the income distribution corresponds to wages received by capitalist households. We conclude that although the linear correspondence between income source and class location is more blurred today than it was 200 years ago, a class divide is still clear.
JEL Codes: E250
Chemical reaction, Thermal radiation and Newtonian heating impacts on Unsteady MHD Rotating Casson fluid flow past an infinite vertical porous surface
Authors: Sekhar B. Chandra , Kumar P. Vijaya , VeeraKrishna M. 
Published: September 2023

Abstract

The influences by the Newtonian heating on temperature in addition mass transport in unsteady MHD flows of the Casson fluids over the perpendicular plate with heat radiating as well as chemically reaction are explored. The Casson fluids modelling were utilized to distinguishing the non-Newtonian liquid behaviour. The fluids movement is persuaded owing to periodical fluctuations by the plate beside those lengths as well as a uniformed transversal magnetic domain is supplied into the directions this is vertical into the directions of fluids flows. The PDEs for leading the flows, temperature, as well as mass transfers are changed into the non-dimensional format utilizing appropriate non-dimensional variables these are afterwards solved methodically by using Laplace transforms methods. The computational quantities of the fluid velocities, temperature, along with species concentration are portrayed graphically. Also the quantities of skin-frictions, Nusselts number, as well as Sherwoods numbers are represented in table format. This is notified that the fluids velocity as well as temperature reduced by the enhancing quantities of Casson parameter whereas the concentration reduces by the increasing quantities of chemically reactions parameter as well as Schmidts number. Thus, a fluid flows modelling has quite a lot of engineering in addition to medical applications those are, in glasses manufacturing, papers productions, purifications of crude oils as well as studying of blood flows in the cardiovascular systems.
Global Longitudinal Strain by Speckle Tracking Echocardiography and Mortality in Septic Patients: an updated systematic review and meta-analysis with trial sequential analysis
Authors: Andrzej Pruszczyk , Mateusz Zawadka , Pawel Andruszkiewicz , Luigi La Via , Antoine Herpain , Ryota Sato , Siddharth Dugar , Chew Michelle S. , Filippo Sanfilippo 
Published: September 2023

Abstract
Background: Septic cardiomyopathy is associated with poor outcomes but its definition remains unclear. In a previous meta-analysis, left ventricular (LV) longitudinal strain (LS) showed significant prognostic value in septic patients, but findings were not robust due to limited number of studies, differences in effect size and no adjustment for confounders.
Methods: We conducted an updated systematic review (PubMed and Scopus up to 14.02.2023) and meta-analysis to investigate the association between LS and survival in septic patients. We included studies reporting global (from three apical views) or regional LS (one or two apical windows). A secondary analysis evaluated the association between LV ejection fraction (EF) and survival using data from the selected studies.
Results: We included fourteen studies (1678 patients, survival 69.6%) and demonstrated an association between better performance (more negative LS) and survival with mean difference (MD):-1.45%;[-2.10,-0.80] (p<0.0001;I2=42%). No subgroup differences were found stratifying studies according to number of views used to calculate LS (p=0.31;I2=16%), severity of sepsis (p=0.42;I2=0%), and sepsis criteria (p=0.59;I2=0%). Trial sequential analysis and sensitivity analyses confirmed the primary findings. Grade of evidence was low. In the included studies, thirteen reported LVEF and we found an association between higher LVEF and survival (MD:2.44%;[0.44,4.45]; p=0.02;I2=42%).
Conclusions: We confirmed that more negative LS values are associated with higher survival in septic patients. The clinical relevance of this difference and whether the use of LS may improve understanding of septic cardiomyopathy and prognostication deserve further investigation. The association found between LVEF and survival is of unlikely clinical meaning.
A flexible Bayesian tool for CoDa mixed models: logistic-normal distribution with Dirichlet covariance
Authors: Martínez-Minaya Joaquín , Rue Haavard 
Published: September 2023

Abstract

Compositional Data Analysis (CoDa) has gained popularity in recent years. This type of data consists of values from disjoint categories that sum up to a constant. Both Dirichlet regression and logistic-normal regression have become popular as CoDa analysis methods. However, fitting this kind of multivariate models presents challenges, especially when structured random effects are included in the model, such as temporal or spatial effects.
To overcome these challenges, we propose the logistic-normal Dirichlet Model (LNDM). We seamlessly incorporate this approach into the R-INLA package, facilitating model fitting and model prediction within the framework of Latent Gaussian Models (LGMs). Moreover, we explore metrics like Deviance Information Criteria (DIC), Watanabe Akaike information criterion (WAIC), and cross-validation measure conditional predictive ordinate (CPO) for model selection in R-INLA for CoDa.
Illustrating LNDM through a simple simulated example and with an ecological case study on Arabidopsis thaliana in the Iberian Peninsula, we underscore its potential as an effective tool for managing CoDa and large CoDa databases.
Indivisibilities in Investment and the Role of a Capacity Market
Authors: Stevens Nicolas , Smeers Yves , Papavasiliou Anthony 
Published: September 2023

Abstract
The topic of pricing non-convexities in power markets has been explored vividly in the literature and among practitioners for the past twenty years. The debate has been focused on indivisibilities in short-term auctions, the computational tractability of some pricing proposals, and the economic analysis of their behavior. In this paper, we analyse a source of non-convexities that is not discussed as broadly: the indivisibilities in investment decisions. The absence of equilibrium that we are primarily concerned about is the long-term equilibrium. We derive a capacity expansion model with indivisibilities and we highlight the issues arising from it. We discuss its relevance and address one particular argument for neglecting indivisibilities in investment, namely market size. We investigate to what extent a capacity market that clears discrete offers can mitigate the lumpiness problem. We particularly introduce the novel concept of convex hull pricing for capacity auctions. We illustrate the main findings with a numerical experiment conducted on the capacity expansion model used by ENTSO-E to assess the adequacy of the entire European system.
JEL Classification: C61 , D41 , D44 , D47 , D50 , L51 , Q41
TLS-RWKV: Real-time Online Action Detection with Temporal Label Smoothing
Authors: Zhu Ziqi , Shao Wuchang , Jiao Dongdong 
Published: September 2023

Abstract

Online action detection (OAD) is a challenging task that involves predicting the ongoing action class in real-time from streaming videos. In this article, we propose a novel approach for OAD based on the RWKV model and introducing temporal label smoothing. The RWKV model effectively captures temporal dependencies while maintaining computational efficiency, making it well-suited for real-time applications. The temporal label smoothing technique enhances the model's robustness in handling ambiguous boundaries and feature similarities near action boundaries. We conducted experiments on two widely used datasets, THUMOS'14 and TVSeries, to evaluate the performance of our proposed approach. Our model achieves state-of-the-art performance with 71.8% mAP on THUMOS'14 and 89.7% cAP on TVSeries. Furthermore, our proposed approach demonstrates impressive efficiency, running at over 600 FPS and maintaining a competitive mAP of 59.9% on THUMOS'14 with RGB features alone. This high efficiency makes our model suitable for real-time deployment, even on resource-constrained devices. These results showcase the effectiveness and competitiveness of our proposed approach in OAD.
Development of A dc-SQUID Amplifier with Intra-coil Resistors
Authors: Wu Wentao , Lin Zhirong , Ni Zhi , Zhang Shuo , Zhang Guofeng , Wang Yongliang , Ying Liliang , Peng Wei , You Lixing , Wang Zhen 
Published: September 2023

Abstract
We have developed a dc-SQUID amplifiers with intra-coil resistors based on second-order parallel gradiometers. The measured results show that intra-coil resistors can significantly increase the flux-voltage transfer coefficient VΦ as well as smooth out resonances and produce a smooth flux-voltage (V-Φ) characteristic curve. It has been observed through a comparison of various intra-coil damping resistors that the flux-voltage transfer coefficient VΦ as a function of the intra-coil resistors rises as the corresponding electric conductance increase. The measured results of the flux noise at 4.2 K demonstrate explicitly that the flux-voltage transfer coefficient can greatly increase detection sensitivity and successfully reduce the noise contribution from the electronics operating at room temperature.