bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracking Chinese newspaper coverage of elephant ivory through topic modeling
Authors: Gao Yufang , Liu Yuntian , Luo Yu , Biggs Duan , Zhao Weiyang , Clark Susan G. 
Published: February 2023

AbstractMass media worldwide has contributed to increasing awareness of the illegal wildlife trade and its significant impact on wildlife conservation. We used mass media coverage as a proxy for macro‐level public opinion to analyze the media framing of elephant ivory in 6394 Chinese newspaper articles published from 2000 to 2021 and thus determine the effects of wildlife policies on public opinion. We focused on 2 events: the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) approval of China as a trading partner in the purchase and import of ivory stockpiles from Africa in July 2008 and the Chinese government's announcement of a domestic ivory ban in December 2016. Using latent Dirichlet allocation topic modeling, we identified 8 topics about elephant ivory and grouped them into 3 frames: ivory arts and culture, ivory crimes, and elephant conservation. Over the last 2 decades, topics related to ivory crimes remained the most prevalent in news articles. Topics about ivory arts and culture showed a significant shift in media salience before and after the 2 events (from 0.44 to 0.19 and from 0.08 to 0.15, respectively, p < 0.05), whereas the other 2 frames did not change significantly. Contrary to popular belief, our results indicated that Chinese macro‐level public opinion on ivory had become more negative following the CITES approval of ivory importation and less negative after the ivory ban announcement, at least for certain periods. The relationship between mass media, public opinion, and wildlife trade policies is complex and requires further examination of the sociopolitical dynamics that influence media narratives. Our results showed the value of topic modeling in monitoring and assessing media representations of wildlife issues in the era of big data. Conservationists should remain vigilant of mass media coverage and collaborate with media practitioners to produce comprehensive narratives on wildlife issues if resources permit.
Impact of alternative histopathology protocols in the dermatopathology laboratory: A prospective quality improvement study
Authors: Hammond Alexander , Covey Sarah , Guo Wanru , Gregory Scott , Bender Nicole R. , Motaparthi Kiran , Walker Addie 
Published: February 2023

AbstractBackgroundHistopathology protocols for processing dermatopathology specimens vary among laboratories.ObjectiveTo determine an optimal histopathology protocol to minimize cost and turnaround time (TAT) for biopsy specimens in a dermatopathology laboratory.MethodsA prospective, 4‐month study compared the mean cost and TAT of producing one versus two initial H&E slides, and zero versus three unstained slides that could be used for frequently used special or immunohistochemical (IHC) stains.ResultsFor all cases, cost was lower for one versus two initial H&E slides, with an insignificant increase in TAT. Producing three vs zero unstained slides incurred higher cost, with no reduction in TAT. In a subset of cases in which frequently used special or IHC stains were performed, cost and TAT were optimized by producing one initial H&E and three unstained slides.ConclusionA protocol of one initial H&E slide and zero unstained slides optimizes cost and TAT in our dermatopathology laboratory. Pigmented lesions and inflammatory dermatoses may benefit from the addition of unstained slides. Further study is needed to quantify this benefit and evaluate for other cases for which an alternative protocol is advantageous.
Effect of insulin degludec versus insulin glargine U100 on nocturnal glycaemia assessed by plasma glucose profiles in people with type 1 diabetes prone to nocturnal severe hypoglycaemia
Authors: Brøsen Julie Maria Bøggild , Agesen Rikke Mette , Kristensen Peter Lommer , Alibegovic Amra Ciric , Andersen Henrik Ullits , Beck‐Nielsen Henning , Gustenhoff Peter , Hansen Troels Krarup , Hedetoft Christoffer , Jensen Tonny , Stolberg Charlotte Røn , Juhl Claus Bogh , Lerche Susanne Søgaard , Nørgaard Kirsten , Parving Hans‐Henrik , Tarnow Lise , Thorsteinsson Birger , Pedersen‐Bjergaard Ulrik 
Published: February 2023

AbstractAimTo compare nocturnal glucose profiles according to hourly plasma glucose measurements during treatment with insulin degludec and insulin glargine U100 in a cohort of people with type 1 diabetes prone to nocturnal severe hypoglycaemia.Materials and methodsThe HypoDeg trial is a 2‐year investigator‐initiated, randomized, controlled crossover trial in 149 participants randomized to treatment with insulin degludec and insulin glargine U100 for 12 months each. The 51 participants in this predefined substudy stayed at least one night in hospital during each treatment arm for plasma glucose samples to be taken. Endpoints were glucose profiles, including mean plasma glucose, glycaemic variability and risk of hypoglycaemia.ResultsThere were no differences between treatments regarding mean plasma glucose. We saw a flatter glucose profile during insulin degludec compared with insulin glargine U100 treatment, which had a nadir at 4:00 AM, with a subsequent rise. During treatment with insulin degludec, the participants had lower glycaemic variability, with an estimated treatment difference of −4.3% (95% confidence interval [CI] −8.1 to −0.5; P < 0.05). Participants treated with insulin degludec were less likely to experience nocturnal hypoglycaemia below 3.0 mmol/L (hazard ratio 0.36 [95% CI 0.17‐0.73; P < 0.05]).ConclusionBased on nocturnal plasma glucose measurements, treatment with insulin degludec compared with insulin glargine U100 administered in the evening results in lower glycaemic variability and lower risk of nocturnal hypoglycaemia without differences in mean plasma glucose.
Effect of local administration of eicosapentaenoic acid on the jaw‐opening reflex in rats
Authors: Osaki Hibiki , Mori Mina , Oshima Katsuo , Shimazu Yoshihito , Takeda Mamoru 
Published: February 2023

AbstractAlthough eicosapentaenoic acid (EPA) application in vitro inhibits voltage‐gated Na+ (Nav) channels in excitable tissues, the acute local effect of EPA on the jaw‐opening reflex in vivo remains unknown. The aim of the present study was to determine whether local administration of EPA to adult male Wistar rats could attenuate the excitability of the jaw‐opening reflex in vivo, including nociception. The jaw‐opening reflex evoked by electrical stimulation of the tongue was recorded by a digastric muscle electromyogram (dEMG) in pentobarbital‐anesthetized rats. The amplitude of the dEMG response was significantly increased in proportion to the electrical stimulation intensity (1×–5× threshold). At 3×, local administration of EPA dose‐dependently inhibited the dEMG response, lasting 60 min, with maximum inhibition observed within approximately 10 min. The mean magnitude of dEMG signal inhibition by EPA was almost equal to that observed with a local anesthetic, 1% lidocaine, and with a half dose of lidocaine plus a half dose of EPA. These findings suggest that EPA attenuates the jaw‐opening reflex, possibly by blocking Nav channels of primary nerve terminals, and strongly support the idea that EPA is a potential therapeutic agent and complementary alternative medicine for the prevention of acute trigeminal nociception.
Family‐based physical activity interventions and family functioning: A systematic review
Authors: Rhodes Ryan E. , Hollman Heather , Sui Wuyou 
Published: February 2023

AbstractFamily physical activity (PA) can confer multiple health benefits, yet whether PA interventions affect general family functioning has not been appraised. The purpose of this review was to evaluate studies that have examined the effect of family PA interventions, where child PA was the focus of the intervention, on constructs of family functioning. Literature searches were concluded on January 11, 2022 using seven common databases. Eligible studies were in English, utilized a family PA intervention, and assessed a measure of family functioning as a study outcome. The initial search yielded 8413 hits, which was reduced to 20 independent PA interventions of mixed quality after screening for eligibility criteria. There was mixed evidence for whether family PA interventions affected overall family functioning; however, analyses of subdomains indicated that family cohesion is improved by PA interventions when children are in the early school years (aged 5–12). High‐quality studies also showed an impact of family PA interventions on family organization. Targeted interventions at specific family subsystems (e.g., father–son, mother–daughter), characteristics (low‐income, clinical populations, girls), and broad multibehavioral interventions may have the most reliable effects. Overall, the findings show that family PA interventions can promote family cohesion and organization, particularly among families with children in the early school years. Higher quality research, employing randomized trial designs and targeting specific intervention and sample characteristics (e.g., different clinical conditions, specific parent–child dyads), is recommended in order to better ascertain the effectiveness of these approaches.
Assessment of the clinical perception, quality of life and satisfaction of patients with severe congenital haemophilia A without inhibitor after 1 year of emicizumab therapy
Authors: Oka Gaëlle , Roussel‐Robert Valérie , Levivien Clara , Lopez Isabelle , Pieragostini Rémi 
Published: February 2023

AbstractIntroductionSince the approval by the EMA of emicizumab for the care of severe haemophilia A without inhibitor, most of the patients of our haemophilia treatment centre started this new treatment. Thanks to the setting of a therapeutic patient education program including three pharmaceutical consultations (PC), we could follow patients’ lifestyle evolution.AimThe study aimed to assess the perceived clinical evolution, quality of life and treatment satisfaction of patients after 1 year of emicizumab therapy in real‐life settings.MethodsThe study was observational, retrospective and monocentric. Every patient over 18 years old receiving emicizumab from June 2020 and who underwent the 3 PC until March 2022 were included. The clinical evolution was self‐estimated by patients with zero‐to‐six scales before versus 1 year after emicizumab, according to the following parameters: general health state, pain and bleedings (spontaneous or post‐traumatic, and patients’ identification ability). Patients’ quality of life was also estimated with the EQ‐5D‐3L survey. Their satisfaction, graduated with a zero‐to‐ten scale, and treatment management were reported during the third PC.ResultsThirty‐eight patients were enrolled. Their general health state improved significantly (p = .0023) with an EQ‐5D‐3L score at 69.6 (±19.4) out of 100. Although chronic pains remained a persistent issue for 33 (86.8%) patients, their intensity was significantly decreasing after 1 year. Perceived frequency of bleedings was significantly reduced too. On average, the satisfaction of emicizumab therapy was 9.1 (± 1.02) out of 10.ConclusionAfter 1 year of emicizumab therapy, the general health state estimated by patients improved, the pain and the perceived frequency of bleedings diminished. Overall, this treatment received a high patients’ satisfaction rate.
Association between dietary inflammatory index and anthropometric indicators of adiposity in Brazilian adolescents
Authors: Blaudt Luana Senna , de Souza Lopes Taís , de Moura Souza Amanda , Yokoo Edna Massae , da Rocha Camilla Medeiros Macedo , Pereira Rosangela Alves 
Published: February 2023

SummaryBackgroundDiet may play a role in the regulation of obesity‐related low‐grade chronic inflammation.ObjectiveAssess the association of the Dietary Inflammatory Index (DII) with anthropometric indicators of adiposity in Brazilian adolescents.MethodsData were collected from 71 740 adolescents (12–17 years old) examined in the Study of Cardiovascular Risks in Adolescents. Food consumption was assessed by means of one 24‐h dietary recall, and DII was estimated using 39 food parameters. The body mass index (weight/height2) for age and sex was used to define overweight (>1 z‐score). Abdominal obesity was indicated by waist circumference (WC) values >80th percentile and waist‐to‐height ratio (WHtR) > 0.50. The association between DII and anthropometric indicators was assessed using logistic regression models.ResultsThe mean DII score was higher in girls than in boys (0.77; SD = 0.04 vs. 0.04; SD = 0.05). Adolescents in the 4th quartile of DII, compared with those in the 1st quartile, had increased odds of being overweight (boys: OR = 1.76; 95% CI: 1.37; 2.25; girls: OR = 1.63; 95%CI: 1.36; 1.95), having abdominal obesity (boys: OR = 1.61; 95%CI: 1.33; 1.95; girls: OR = 1.73; 95%CI: 1.48; 2.03), and having high WHtR (boys: OR = 1.91; 95%CI: 1.52; 2.39; girls: OR = 1.75; 95%CI: 1.46; 2.11).ConclusionsThe findings showed a direct association between the dietary inflammatory potential measured by DII and adiposity.
Idiopathic ventricular fibrillation associated with long‐coupled Purkinje ectopy
Authors: Surget Elodie , Duchateau Josselin , Marchant James , Maury Philippe , Walton Richard , Lavergne Thomas , Gandjbakhch Estelle , Leenhardt Antoine , Extramiana Fabrice , Haïssaguerre Michel 
Published: February 2023

AbstractIntroductionIdiopathic ventricular fibrillation (IVF) is mainly associated with and triggered by short‐coupled (R‐on‐T) ventricular ectopics. However, little is known about the risk of VF associated with long‐coupled premature ventricular complexes (LCPVCs).ObjectiveTo examine the prevalence and characteristics of IVF patients presenting with LCPVCs.MethodsConsecutive patients with IVF and PVCs from five arrhythmia referral centers were reviewed. We included patients presenting LCPVCs, defined as PVCs falling after the end of the T wave, with a normal QTc interval. We evaluated demographics, medical history, and clinical circumstances associated with PVCs and VF episodes. The origin of PVCs was determined by invasive mapping.ResultsSeventy‐nine patients with IVF were reviewed. Among them, 12 (15.2%) met the inclusion criteria (8 women, age 36 ± 14 years). Eleven patients had documented LCPVCs initiating repetitive PVCs or sustained VF, whereas 1 had only documented isolated PVCs. In 10 of 12 patients, PVCs were recorded showing both long and short coupling intervals of 418 ± 46 and 304 ± 33 ms, respectively. Mapping showed that PVCs originated from the left Purkinje in 10 patients, from the right Purkinje in 1 patient, and both in 1 patient. Compared to other patients from the initial cohort, IVF with LCPVCs was associated with a left‐sided origin of PVCs (92% in long‐coupled IVF vs. 46% of left Purkinje PVCs in short‐coupled IVF, p = .004).ConclusionLong‐coupled fascicular PVCs, traditionally recognized as benign, can be associated with IVF in a subset of patients. They can induce IVF by themselves or in association with short‐coupled PVCs.
First identification of mycobacteriosis in Atlantic mackerel (Scomber scombrus)
Authors: Sandlund Nina , Skår Cecilie , Karlsbakk Egil 
Published: February 2023

AbstractMycobacterium infection in fish is a well‐known disease problem globally, mainly in the farming of ornamental fish or fish for food. Less is known about the prevalence, distribution and the effects such infections have on wild fish species. Presumptive mycobacteriosis has previously been observed in Atlantic mackerel (Scomber scombrus). Since 2018, there has been an increase in reports of granulomatous kidney disease in Atlantic mackerel with the suspicion of this being mycobacteriosis. A total of six individuals were sent to the Institute of Marine Research for further examination. They were caught in the Nordic Sea by either commercial fishing vessels or during the International Ecosystem Summer Survey in the Nordic Seas (IESSNS research cruise) between 2018 and 2020. Samples for both histological and molecular analysis were collected. Here, we detect a likely novel Mycobacterium species in tissue samples from Atlantic mackerel with this condition, on the basis of rDNA and protein gene sequences. The same unnamed bacterium seems to have been found in some Pacific marine fishes. The macroscopic and histological manifestation of the disease is described. Over the past years, there has been an increase in reports of mycobacteriosis worldwide and climate change has been suggested as one of the driving forces as these bacteria prefer warm water.
Examining the impact of major life events on the frequency and experience of daily social events
Authors: Jayawickreme Eranda , Tsukayama Eli , Blackie Laura E. R. 
Published: February 2023

AbstractObjectiveLife events can impact people's dispositional functioning by changing their state‐level patterns of thoughts, feelings, and behavior. One pathway through which this change may be facilitated is changes in the experience of daily social events.MethodWe examined the dynamic relationship between major life events and the subsequent experience of positive and negative daily social events in a year‐long longitudinal study (initial N = 1247).ResultsExperiencing positive and negative major life events moderated the effects of positive and negative social events on event‐contingent state well‐being and ill‐being in ways that were mostly (but not always) consistent with both endowment and contrast effects on judgments of well‐being. Furthermore, negative life events predicted an increase in the subsequent trajectory of negative social events, while the experience of daily ill‐being predicted the subsequent experience of negative social events.ConclusionsThese findings highlight the possible impact of major life events by explaining how they shape the subsequent experience of daily social events.
Pollution effects of place‐based policy: Evidence from China's development‐zone program
Authors: Hua Yue , Partridge Mark , Sun Weizeng 
Published: February 2023

AbstractEnvironmental externalities of place‐based policy have generally been overlooked despite their welfare consequences. This paper studies the air‐pollution effect of development zones in urban China using a geo‐coded data set of 2720 counties from 1998 to 2016. By adopting the generalized difference‐in‐difference framework to resolve the problem of endogenous locational selection for place‐based policies, we find that development zones reduce ambient PM2.5 concentration by around 1.8%, leading to a total social gain of $7.75 billion USD. The environmental benefit varies by the zone's dominant industry, geographical region, administrative affiliation and time of establishment. We further show that development zones are comparably cleaner due to the incentives of central and local governments, manifested by the desire to administratively promote development zones, the attempt to satisfy residential demands for higher quality‐of‐life cities, and the employment of the national environmental monitoring system.
The SET domain protein PsKMT3 regulates histone H3K36 trimethylation and modulates effector gene expression in the soybean pathogen Phytophthora sojae
Authors: Chen Han , Fang Yujie , Song Wenrui , Shu Haidong , Li Xi , Ye Wenwu , Wang Yuanchao , Dong Suomeng 
Published: February 2023

AbstractPlant pathogens secrete effector proteins to overcome host immunity and promote colonization. In oomycete plant pathogens, the expression of many effector genes is altered upon infection; however, the regulatory mechanisms are unclear. In this study, we identified a su(var)3–9, enhancer of zeste, and trithorax (SET) domain protein‐encoding gene, PsKMT3, that was highly induced at early infection stages in Phytophthora sojae. Deletion of PsKMT3 led to asexual development and pathogenicity defects. Chromatin immunoprecipitation followed by sequencing (ChIP‐seq) and western blot analyses demonstrated that histone H3K36 trimethylation (H3K36me3) was significantly reduced genome‐wide in mutants. RNA‐seq analysis identified 374 genes encoding secreted proteins that were differentially expressed in pskmt3 at the mycelium stage. The significantly altered genes encompassed the RxLR (Arg‐x‐Lys‐Arg) effector gene family, including the essential effector genes Avh23, Avh181, Avh240, and Avh241. Transcriptome analysis at early infection stages showed misregulation of effector gene expression waves in pskmt3. H3K36me3 was directly and indirectly associated with RxLR effector gene activation. Our results reveal a role of a SET domain protein in regulating effector gene expression and modulating histone methylation in P. sojae.
The phenomenology of auditory verbal hallucinations in bipolar disorder
Authors: Smith Lindsay M , Yolland Caitlin , Rossell Susan L. , Toh Wei Lin 
Published: February 2023

AbstractObjectivesAt least one in four persons with bipolar disorder (BD) are estimated to have experienced auditory verbal hallucinations (AVH) or heard voices at some point. Yet few studies have investigated AVH in detail in this population. This preliminary study examined the phenomenology of AVH in BD to identify commonalities and differences relative to other psychiatric disorders where AVH are commonly reported.MethodTwenty‐one participants diagnosed with BD were recruited across two international sites in the UK and Australia. All participants underwent a structured clinical interview to verify psychiatric diagnosis and completed standardised measures of symptomatology, including mood states. Phenomenological information of AVH was gathered using select questions from the comprehensive Mental Health Research Institute Unusual Perceptual Schedule (MUPS).ResultsAVH experienced by this BD sample were broadly similar in form and content to characterisations reported in the schizophrenia spectrum disorders (SSD) in prior literature, with some exceptions including frequency, duration and the changeability of tone and content.ConclusionsThe study highlights possibly subtle differences in the experience of AVH in BD, including the potential influence of mood congruence as a pertinent clinical feature. Further research into these differences might inform adaptations to existing AVH interventions to ensure they are relevant for BD.
Analytic Catholic Epistemologies of Faith: A Survey of Developments
Authors: McNabb Tyler Dalton 
Published: February 2023

AbstractIf you were to take a time machine and travel back to the 1980s, Catholic epistemology would look drastically different than it does today, at least in analytic circles. One of those drastic changes relates to whether Catholic epistemology is consistent with Reformed epistemology. Another issue relates to whether St. Thomas Aquinas was a classical evidentialist. In this paper, I survey recent developments in Catholic epistemology. I do this by first looking at Gregory Stacey's recent work arguing the Catholic Church's teaching on faith is best situated in a Reformed epistemological framework. I then engage decades old objections to Reformed epistemology from a Catholic perspective. I respond to these objections partly by surveying recent work by Catholic epistemologists. The paper then takes a turn to look at the recent scholarship on Aquinas' epistemology. I show that there is now an emerging consensus that Aquinas belongs not to a hard evidentialist camp as it was previously thought, but rather an externalist friendly tradition.