bluuebunny/crossref_metadata_2025_split huggingface dataset:
New horizons in hearing conditions
Authors: Henshaw Helen , Calvert Sian , Heffernan Eithne , Broome Emma E , Burgon Clare , Dening Tom , Fackrell Kathryn 
Published: August 2023

Abstract
Hearing conditions such as hearing loss, tinnitus and hyperacusis are highly prevalent in the population and can severely impact communication and quality of life. Hearing is affected by multiple factors, including heredity, noise exposure, age, sex, ear disorders and lifestyle factors. Globally, hearing loss affects over 80% of adults aged 80 years and older, is often experienced in combination with other long-term health conditions and is a mid-life risk factor for dementia. To form a themed collection, we searched Age and Ageing for articles on hearing conditions published from 2000 onwards. This resulted in 22 articles included within the collection. They examined a range of important topics related to hearing healthcare and research, including noise-induced hearing loss, health service quality and safety, psychological and psychosocial consequences of hearing loss and co-morbidities of hearing loss. All articles reported on hearing loss; there were no published articles with a primary focus on other hearing conditions such as tinnitus or hyperacusis, on the health of older people from the Deaf community or on users of Cochlear implants, suggesting key gaps in knowledge and targets for future research. This New Horizons article highlights novel directions in research and practice and takes a forward look at how research into hearing conditions may develop in years to come. It highlights opportunities for the growth of patient-centred research and hearing healthcare supported by the better integration of health and care services as well as cross-speciality working to include common co-morbid health conditions.
Postoperative Mechanomodulation Decreases T-Junction Dehiscence After Reduction Mammaplasty: Early Scar Analysis From a Randomized Controlled Trial
Authors: Panton Jasmine , Vingan Nicole , Barillas Jennifer , Akgul Yucel , Lazzarini Ariane , Coroneos Christopher J , Amirlak Bardia , Kenkel Jeffrey , Culver Abby 
Published: August 2023

Abstract

Background
Soft tissue and cutaneous tension is an important contributor to complicated wound healing and poor scar cosmesis after surgery and its mitigation is a key consideration in aesthetic and reconstructive procedures.

Objectives
The study objective was to assess the efficacy of the force modulating tissue bridge (FMTB) (“Brijjit”, Brijjit Medical Inc., Atlanta, GA) in reducing mechanical tension on postoperative wounds.

Methods
A prospective, single-center, randomized, within-subject clinical trial was conducted to evaluate wound healing and nascent scar formation after 8 weeks of postoperative wound support with the FMTB. Patients received standard of care (SOC) subcuticular closure on the vertical incision of 1 breast and experimental closure with the FMTB on the contralateral incision after Wise-pattern reduction mammaplasty. Three-dimensional wound analysis and rates of T-junction dehiscence were evaluated by clinical assessment at 2, 4, 6, and 8 weeks postsurgery.

Results
Thirty-four patients (n = 68 breasts) completed 8 weeks of postoperative FMTB application. There was a reduced rate of T-junction wound dehiscence in FMTB breasts (n = 1) vs SOC breasts (n = 11) (P &lt; .01). The mean vertical incision wound area during the intervention period was significantly decreased in the FMTB breast (1.5 cm2) vs the SOC breast (2.1 cm2) (P &lt; .01) and was significantly lower at 2-, 4-, and 8-week follow-up (P &lt; .01). Only the closure method was significantly associated with variations in Week 8 wound area (P &lt; .01) after linear regression modeling.

Conclusions
FMTBs decrease nascent scar dimensions and reduce the occurrence of wound dehiscence. This study provides evidence that the use of continuous mechanomodulation significantly reduces postoperative wound complications after skin closure.

Level of Evidence: 2
MSDRP: a deep learning model based on multisource data for predicting drug response
Authors: Zhao Haochen , Zhang Xiaoyu , Zhao Qichang , Li Yaohang , Wang Jianxin 
Published: August 2023

Abstract

Motivation
Cancer heterogeneity drastically affects cancer therapeutic outcomes. Predicting drug response in vitro is expected to help formulate personalized therapy regimens. In recent years, several computational models based on machine learning and deep learning have been proposed to predict drug response in vitro. However, most of these methods capture drug features based on a single drug description (e.g. drug structure), without considering the relationships between drugs and biological entities (e.g. target, diseases, and side effects). Moreover, most of these methods collect features separately for drugs and cell lines but fail to consider the pairwise interactions between drugs and cell lines.

Results
In this paper, we propose a deep learning framework, named MSDRP for drug response prediction. MSDRP uses an interaction module to capture interactions between drugs and cell lines, and integrates multiple associations/interactions between drugs and biological entities through similarity network fusion algorithms, outperforming some state-of-the-art models in all performance measures for all experiments. The experimental results of de novo test and independent test demonstrate the excellent performance of our model for new drugs. Furthermore, several case studies illustrate the rationality for using feature vectors derived from drug similarity matrices from multisource data to represent drugs and the interpretability of our model.

Availability and implementation
The codes of MSDRP are available at https://github.com/xyzhang-10/MSDRP.
Use of systemic and biological therapy in patients with moderate-to-severe psoriasis
Authors: Liljendahl Mie S , Loft Nikolai , Nguyen Tri-Long , Skov Lone , Egeberg Alexander 
Published: August 2023

Abstract

Background
Patients with moderate-to-severe psoriasis are candidates for systemic treatment, but it is unknown how many receive such therapy at a national level in Denmark.

Objectives
We aimed to determine the prevalence of conventional systemic therapy use in patients with moderate-to-severe psoriasis and, further, to investigate the time to discontinuation of conventional systemic therapy and initiation of biological therapy among biologic-naïve patients.

Methods
This registry-based study identified a cohort of patients with psoriasis in Denmark. We estimated the prevalence of moderate-to-severe psoriasis at a national level using registry data. Inverse probability weighting was used to mitigate potential selection bias in the prevalence estimate of moderate-to-severe psoriasis. Analyses were then performed on the weighted cohort.

Results
Of patients with psoriasis in Denmark, 10.9% were estimated to have moderate-to-severe psoriasis, of whom 62.3% received either conventional systemic or biological therapy, meaning 37.7% who were considered candidates for systemic therapy did not receive any systemic treatment. The study demonstrated that, comparing previous time periods with more recent years: (i) time on conventional systemic therapy for patients with moderate-to-severe psoriasis has become shorter, with a median (interquartile range) of 3.0 years (0.6–10.0) in 1985–1994 vs. 0.6 years (0.3–2.0) in 2014–2018; (ii) more patients initiated biologics as second-line therapy, with 69.5% in 2010–2013 vs. 71.2% in 2014–2018; and (iii) the median time from initiation of systemic therapy to initiation of biological therapy decreased from 13.3 years (11.5–16.8) in 2010–2013 to 1.9 years (1.7–2.4) in 2014–2018.

Conclusions
This study found that nearly 37.7% of Danish patients with moderate-to-severe psoriasis do not receive systemic treatment even though they would qualify for this. Furthermore, for patients treated with conventional systemics, drug survival decreased during the observation period.
Quantification of Urine and Plasma Porphyrin Precursors Using LC–MS in Acute Hepatic Porphyrias: Improvement in Routine Diagnosis and in the Monitoring of Kidney Failure Patients
Authors: Poli Antoine , Manceau Hana , Nguyen Anvi Laetitia , Moulouel Boualem , Dessendier Nathalie , Talbi Neila , Puy Hervé , Junot Christophe , Gouya Laurent , Schmitt Caroline , Lefebvre Thibaud 
Published: August 2023

Abstract

Background
The quantification of delta-aminolevulinic acid (ALA) and porphobilinogen (PBG) in urine are the first-line tests for diagnosis and monitoring of acute hepatic porphyrias (AHP). Ion-exchange chromatography (IEC), which is time- and staff-consuming and limited to urine, is still the preferred method in many specialized laboratories, despite the development of mass spectrometry-based methods.

Methods
We describe a new LC-MS method that allows for rapid and simple quantification of ALA and PBG in urine and plasma with an affordable instrument that was used to analyze 2260 urine samples and 309 blood samples collected in 2 years of routine activity. The results were compared to those obtained with IEC, and urine reference ranges and concentrations in asymptomatic carriers were determined. Plasma concentrations were measured in healthy subjects and subgroups of symptomatic and asymptomatic AHP carriers.

Results
In urine, the clinical decision limits were not impacted by the change of method despite discrepancies in low absolute concentrations, leading to lower normal values. Two-thirds of asymptomatic AHP carriers (with the exception of coproporphyria carriers) showed an increased urine PBG concentration. Urine and plasma levels showed a good correlation except in patients with kidney disease in whom the urine/plasma ratio was relatively low.

Conclusion
We described an LC-MS based method for the routine diagnosis and monitoring of AHP that allows for the detection of more asymptomatic carriers than the historical method. Blood analysis appears to be particularly relevant for patients with kidney disease, where urine measurement underestimates the increase in ALA and PBG levels.
Oxidative physiology of two small and highly migratory Arctic seabirds: Arctic terns (Sterna paradisaea) and long-tailed jaegers (Stercorarius longicaudus)
Authors: Fowler Melinda A , Wong Joanna B , Harrison Autumn-Lynn 
Published: August 2023

Abstract
Arctic ecosystems are changing rapidly. The tundra supports nesting migratory seabirds that spend most of their year over the ocean. Migrations are demanding, but it is unclear how physiological capability may equip organisms to respond to their changing environments. For two migratory seabird species nesting in Alaska, USA, the Arctic tern (n = 10) and the long-tailed jaeger (n = 8), we compared oxidative physiology and aerobic capacity measured during incubation and we recorded individual movement paths using electronic tracking tags. Within species, we hypothesized that individuals with longer-distance migrations would show higher oxidative stress and display better aerobic capacity than shorter-distance migrants. We examined blood parameters relative to subsequent fall migration in jaegers and relative to previous spring migration in terns. We present the first measurements of oxidative stress in these species and the first migratory movements of long-tailed jaegers in the Pacific Ocean. Arctic terns displayed positive correlation of oxidative variables, or better integration than jaegers. Relative to physiological sampling, pre-breeding northward migration data were available for terns and post-breeding southward data were available for jaegers. Terns reached a farther maximum distance from the colony than jaegers (16 199 ± 275 km versus 10 947 ± 950 km) and rate of travel northward (447 ± 41.8 km/day) was positively correlated with hematocrit, but we found no other relationships. In jaegers, there were no relationships between individuals’ physiology and southward rate of travel (193 ± 52.3 km/day) or migratory distance. While it is not clear whether the much longer migrations of the terns is related to their better integration, or to another factor, our results spark hypotheses that could be evaluated through a controlled phylogenetic study. Species with better integration may be less susceptible to environmental factors that increase oxidative stress, including thermal challenges or changes in prey distribution as the Arctic climate changes rapidly.
Single accessory pathway with multiple insertions? First-in-human 3D visualization using dipole charge density mapping: a case report
Authors: Minciuna Ioan-Alexandru , Gagyi Rita B , Wijchers Sip , Szili-Torok Tamas 
Published: August 2023

Abstract

Background
Accessory pathways (APs) with multiple atrial insertions are often unrecognized and associated with initial catheter ablation (CA) failure. Recently, a novel dipole charge density mapping (DCDM) system was developed that allows mapping of complex arrhythmias based on a single beat. We aim to present the first-in-human report of 3D visualization of a single AP with two atrial insertion sites using high-resolution DCDM.

Case summary
A 43-year-old man with recurrent symptomatic atrioventricular re-entrant tachycardia and previously failed CA attempts underwent repeated CA using DCDM. Dipole charge density mapping identified two quasi-simultaneous early atrial activation sites at the left lateral and left anterolateral atrial aspects of the mitral annulus, suggesting the presence of a single AP with dual atrial insertion sites. Successful radiofrequency CA was performed at the mid-body of the AP.

Discussion
The true prevalence of APs with multiple atrial insertion sites may be higher than currently reported. This is the first-in-human report of 3D visualization of a single AP with two atrial insertion sites using high-resolution DCDM. Dipole charge density mapping allows the accurate localization of APs with multiple insertion sites based on a single beat.
Computed tomographic–based three-dimensional printing of giant coronary artery fistulas to guide surgical strategy: a case series
Authors: Ørbæk Andersen Mads , Smerup Morten H , Munk Kim , Mortensen Ulrik Markus , Nørgaard Bjarne Linde , Helvind Morten , Andersen Henrik Ørbæk , Linde Jesper James 
Published: August 2023

Abstract

Background
Coronary artery fistulas (CAFs) are abnormal communications between the coronary arteries and the heart chambers, arteries, or veins, potentially leading to significant shunting, myocardial ischaemia and heart failure. Computed tomographic (CT) angiography or conventional invasive angiography is the reference standard for the diagnosis of coronary fistulas. The fistula anatomy can become very complex, which makes surgical or interventional planning challenging.

Case summary
We report two cases of hugely dilated and tortuous coronary circumflex artery fistulas draining into the coronary sinus. Both patients were followed up for more than 10 years because of very complex coronary fistula anatomy and mild symptoms. From two-dimensional (2D) sliced CT images alone it, was uncertain whether surgery was feasible. However, since both patients had symptom progression (Patient 1 developed heart failure, and Patient 2 had recurrent pericardial effusions), three-dimensional (3D) heart models were printed for better understanding of the complex fistula anatomy and improved surgical planning. Both patients had successful surgery and symptomatic relief at follow-up.

Discussion
The delay in surgery, until clinical deterioration, may partly be a consequence of a general reluctance in performing complex surgery in patients with CAFs. As of now, CT-based 3D printing has primarily been used in isolated cases. However, 3D printing is evolving rapidly and supplementing 2D sliced CT images with a physical 3D heart model may improve the anatomical understanding and pre-surgical planning that could lead to better surgical outcome.
Spontaneous coronary artery dissection with leucoencephalopathy associated with thrombospondin Type 1 domain containing 1 gene mutation: a case report
Authors: Ranasinghe Gotabhaya , Sovis Rasika , Shellvacumar Sajeev , Dissanayake Vajira H W 
Published: August 2023

Abstract

Background
Spontaneous coronary artery dissection (SCAD) is increasingly diagnosed as one of the infrequent causes of acute coronary syndrome. Almost no cause was identified in half of the cases. Here, we report a rare case of spontaneous coronary artery dissection with leucoencephalopathy (SCADLE) associated with a mutation of the thrombospondin Type 1 domain containing 1 (THSD1) gene.

Case summary
A 36-year-old lady who presented with ischaemic type chest pain for 4 h duration and found to have anterior ST elevation myocardial infarction. She was thrombolysed with tenecteplase and had good resolution. Her coronary angiogram revealed a spontaneous dissection in the left anterior descending artery (LAD) with TIMI 3 flow. Intra-vascular ultrasound study confirmed the LAD spiral dissection and intramural haematoma. She has had recurrent transient ischaemic attacks 5 years and 7 years ago, and there was a significant family history of young stroke. Her magnetic resonance imaging (MRI) brain showed peri-ventricular white matter hyper-intensities and lacunar infarcts suggestive of leucoencephalopathy. An association with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) and SCAD was suspected, and exome gene sequencing followed by genetic analysis was performed. It identified a variant c.67°C &gt; G (p. Arg224Gly) in the THSD1 gene with normal NOTCH gene.

Discussion
Thrombospondin Type 1 domain containing 1 gene encodes proteins involving in the extra-cellular matrix (ECM). This THSD1 mutation is inherited as an autosomal dominant fashion and associated with arterial dissections (rare), fibromuscular dysplasia, intra-cranial aneurysm, and subarachnoid haemorrhages. Therefore, SCADLE could be a result of arteriopathy secondary to dysfunction of ECM proteins in cerebral and coronary vasculature resulting in neurological manifestations and MRI features like in CADASIL and SCAD.
Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality
Authors: Nemet Ina , Li Xinmin S , Haghikia Arash , Li Lin , Wilcox Jennifer , Romano Kymberleigh A , Buffa Jennifer A , Witkowski Marco , Demuth Ilja , König Maximilian , Steinhagen-Thiessen Elisabeth , Bäckhed Fredrik , Fischbach Michael A , Tang W H Wilson , Landmesser Ulf , Hazen Stanley L 
Published: August 2023

Abstract

Aims
Precision microbiome modulation as a novel treatment strategy is a rapidly evolving and sought goal. The aim of this study is to determine relationships among systemic gut microbial metabolite levels and incident cardiovascular disease risks to identify gut microbial pathways as possible targets for personalized therapeutic interventions.

Methods and results
Stable isotope dilution mass spectrometry methods to quantitatively measure aromatic amino acids and their metabolites were used to examine sequential subjects undergoing elective diagnostic cardiac evaluation in two independent cohorts with longitudinal outcome data [US (n = 4000) and EU (n = 833) cohorts]. It was also used in plasma from humans and mice before vs. after a cocktail of poorly absorbed antibiotics to suppress gut microbiota. Multiple aromatic amino acid-derived metabolites that originate, at least in part, from gut bacteria are associated with incident (3-year) major adverse cardiovascular event (MACE) risks (myocardial infarction, stroke, or death) and all-cause mortality independent of traditional risk factors. Key gut microbiota-derived metabolites associated with incident MACE and poorer survival risks include: (i) phenylacetyl glutamine and phenylacetyl glycine (from phenylalanine); (ii) p-cresol (from tyrosine) yielding p-cresol sulfate and p-cresol glucuronide; (iii) 4-OH-phenyllactic acid (from tyrosine) yielding 4-OH-benzoic acid and 4-OH-hippuric acid; (iv) indole (from tryptophan) yielding indole glucuronide and indoxyl sulfate; (v) indole-3-pyruvic acid (from tryptophan) yielding indole-3-lactic acid and indole-3-acetyl-glutamine, and (vi) 5-OH-indole-3-acetic acid (from tryptophan).

Conclusion
Key gut microbiota-generated metabolites derived from aromatic amino acids independently associated with incident adverse cardiovascular outcomes are identified, and thus will help focus future studies on gut-microbial metabolic outputs relevant to host cardiovascular health.
Placing patient-reported outcomes at the centre of cardiovascular clinical practice: implications for quality of care and management
Authors: Moons Philip , Norekvål Tone M , Arbelo Elena , Borregaard Britt , Casadei Barbara , Cosyns Bernard , Cowie Martin R , Fitzsimons Donna , Fraser Alan G , Jaarsma Tiny , Kirchhof Paulus , Mauri Josepa , Mindham Richard , Sanders Julie , Schiele Francois , Torbica Aleksandra , Zwisler Ann Dorthe 
Published: August 2023

AbstractPatient-reported outcomes (PROs) provide important insights into patients’ own perspectives about their health and medical condition, and there is evidence that their use can lead to improvements in the quality of care and to better-informed clinical decisions. Their application in cardiovascular populations has grown over the past decades. This statement describes what PROs are, and it provides an inventory of disease-specific and domain-specific PROs that have been developed for cardiovascular populations. International standards and quality indices have been published, which can guide the selection of PROs for clinical practice and in clinical trials and research; patients as well as experts in psychometrics should be involved in choosing which are most appropriate. Collaborations are needed to define criteria for using PROs to guide regulatory decisions, and the utility of PROs for comparing and monitoring the quality of care and for allocating resources should be evaluated. New sources for recording PROs include wearable digital health devices, medical registries, and electronic health record. Advice is given for the optimal use of PROs in shared clinical decision-making in cardiovascular medicine, and concerning future directions for their wider application.