bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can anti-thyroglobulin antibody (anti-Tg) be a tumor marker for recurrence in papillary thyroid carcinoma (PTC) in patients without autoimmune thyroiditis (AIT)?: A case report
Authors: Begüm Bahçecioğlu Adile , Faik Erdoğan Murat 
Published: January 2023

Abstract

Introduction
Thyroid carcinoma is the most common malignancy of the endocrine system, accounting for 1% of all newly diagnosed cancers. Thyroglobulin (Tg) is a tumor marker for papillary thyroid carcinoma (PTC) if the anti-thyroglobulin antibody (anti-Tg) is negative. In autoimmune thyroiditis (AIT) patients with positive anti-Tg, the level of this antibody can be a marker in the follow-up of PTC, since the anti-Tg concentration depends on the amount of Tg-secreting tissue. However, there is no clear data on whether the development of anti-Tg positivity during follow-up is an indicator of recurrence in a patient who has neither AIT nor anti-Tg positivity before surgery.

Clinical Case
21-year-old male admitted to our hospital with a complaint of a palpable mass on the neck. The patient was euthyroid and thyroid autoantibodies were negative. In neck ultrasonography (US), 10 mm EU-TIRADS 5 nodule in right lobe and pathologic lymphs nodes in right cervical compartments were detected, and FNABs were done.
Results were consistent with PTC. Total thyroidectomy, central and right neck dissection were performed. Histopathology report resulted in classic variant 2 cm PTC in right lobe, one central and 10 lateral pathologic lymph nodes among a total of 41. While 150 mCi RAI was given as adjuvant therapy; TSH level was 109 µIU/ml, Tg was 11 ng/mL and anti-Tg was negative. No involvement was detected in the post-RAI whole body scan except microscopic residual RAI avid foci in the thyroid bed and upper mediastinum. No pathologic focus was observed in the upper mediastinum in thorax CT. During one year, he was followed with an excellent response. At the end of the first year after surgery, anti-Tg antibody was detected as positive with 6.63 IU/mL (0–4 normal range) when neck ultrasonography and thyroglobulin were negative (&lt;0.1 ng/mL). At the end of the second year that the patient was under close follow-up, the anti-Tg titer increased to 8 IU/mL and neck US revealed a single suspicious 7×6mm, round lymph node, with loss of normal hilum, in the central compartment (level VI-VII). Central lymph node dissection was performed when Tg washout was positive in this lymph node. Histopathological examination resulted in two metastatic (2 and 3 mm) lymph nodes out of four lymph nodes removed. In postoperative third months, Tg and anti-Tg were negative.

Conclusion
This case shows that anti-Tg can be used as a tumor marker for PTC in patients without AIT. It was thought that the autoimmunity that developed afterwards against the thyroglobulin antigen might have been triggered by the thyroglobulin that passed into the serum after the adjuvant rai treatment, and it might have turned into a tumor marker in this way for this patient. Therefore, we recommend that anti-Tg testing should be continued in the follow-up of patients with PTC whose anti-Tg were not positive before surgery.
Difficult situation in treatment of medullary thyroid carcinoma in patient with multiple endocrine neoplasia type 2 B(MEN2B)
Authors: Mohammed Adel Gassab 
Published: January 2023

Abstract

Introduction
Multiple endocrine neoplasia type 2B (also known as ‘MEN2B’,‘Multiple endocrine neoplasia type 3′ or ‘Wagenmann–Froboese syndrome’) is a genetic disease characterized by the presence of medullary carcinoma of the thyroid, pheochromocytoma, mucosal neuromas, marfanoid features and multiple skeletal abnormalities such as kyphoscoliosis and pes cavus.

Clinical Case
A 16 years male presented with neck swelling and dysmorphic feature in the form of marfanoid habitus, including multiple tongue and oral mucosal swelling with mucosal neuromas on the anterior third of the tongue, the lips and the inner eyelid. Lips are thickened and bumpy. Visible neck swelling, palpable solid neck mass, high arm span to height ratio at &gt;1.05, elongated fingers, pes cavus and positive wrist sign which is defined as when the distal phalanges of the thumb and fifth finger overlap on encircling the opposite wrist, were present. Ultrasound of the neck revealed a left solid irregular mass (57mmx33mm), that is hypoechoic, has coarse calcification, hypervascularity, that is mostly central, Multiple cervical lymph node(abnormal nodes include shape (round), absent hilum, intranodal necrosis, reticulation, calcification, peripheral vascularity),Investigation at beginning, Normal thyroid function test and biochemical and electrolyte were observed, Chest x ray was normal, FNAC done for thyroid nodule that showed multiple clumps of large hyperchromatic oval cells picture suggesting high suspicion of thyroid malignancy, thyroid biopsy advised, The patient was referred the FDEMC center for further evaluation and investigation prior to the surgery. During investigation at FDEMC center, thyroid function test normal, biochemistry normal, including PTH and electrolytes, Calcitonin was very high 465 pg/mL (0.2–27.7 pg/mL),GH under GTT was normal, IGF 1 182µg/L (150–350),Plasma metanephrine 40 pg/ml(&lt;90pg/ml),and Plasma normetanephrine 27pg/ml(&lt;196pg/ml) were normal.
The patient referred to surgery, total thyroidectomy with radical neck dissection with multiple lymph node resection was performed.
The biopsy revealed medullary thyroid carcinoma with cervical lymph node secondaries (bilateral multiple foci in both lobes).
The patient kept on levothyroxine tab 100mcg.The follow up of the patient after one month by ultrasound and calcitonin level revealed residual thyroid tissue and two large cervical LN in the the ultrasound and a calcitonin level of 322 pg/mL
Another surgical neck dissection to the metastatic LN &lt;multiple LN 7×5cm, multiple suprasternal mass dissection 3×2.5cm,remnant of thyroid tissue 0.8cm,Follow up the patient after one month by ultrasound and calcitonin level still showed that there is residual pathological cervical LN, while the calcitonin level still high 412 pg/mL. PET scan done for him showed there is uptake in the head, neck and chest. The calcitonin was repeatedly was high.
Systematic Review Reporting - Writing concisely and precisely
Authors: Chien Patrick , Khan Khalid 
Published: January 2023

Systematic reviews rank at the top of the evidence hierarchy. Concise writing implies drafting the systematic review article succinctly, i.e. using as few words to express as full an extent of the research effort as possible. Precise writing means drafting the text with accuracy especially with respect to the methodological and statistical aspects. The Abstract ought to be succinct and structured to allow for editors, peer reviewers and readers to get the gist of the key aspects of the systematic review with a quick read. The readership needs to be able to critically appraisal systematic reviews for their internal and external validity rapidly. The Abstract also needs to be standalone, representing an independent summary that can be fully understood without the need for reading the full paper. The standard structure of the main text of a scientific article called IMRaD (Introduction, Methods, Results and Discussion) applies equally to systematic reviews in the same way as it does to any other kinds of research manuscripts whether related to laboratory experiments or clinical trials. Restricting the word count limits to those imposed by journals may at first seem difficult, even unfair, to systematic reviewers. However, with the availability of online appendices to transparently and fully report the details of the methods, results and other aspects of the work undertaken allows for a succinct print or PDF article. Writing a shorter manuscript is more effortful than writing a longer report. This commentary is aimed at novice systematic reviewers to help them learn the written and unwritten writing rules in order to assist them in producing impactful publications to support evidence-based medicine.
doi: https://doi.org/10.12669/pjms.39.2.7428
How to cite this: Chien PFW, Khan KS. Systematic Review Reporting - Writing concisely and precisely. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.7428
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
CHARACTERISTICS OF INTER-SYSTEM INTERACTIONS BETWEEN MORPHOTYPE AND NEURODYNAMIC OF STUDENTS WITH DIFFERENT BMI LEVELS
Authors: Maltsev Victor P. , Govorukhina Alena A. , Malkov Oleg A. 
Published: January 2023

Purpose. To study morphotype and neurodynamic peculiarities and their intersystem relationship in students with different BMI levels living in Khanty-Mansi Autonomous Okrug – Yugra.
Materials and methods. The research covered 174 first-year students of Surgut State Pedagogical University: 33 male and 141 female students. The study was conducted on a voluntary basis, with written informed consent to be examined. Anthropometric indices, body composition (Tanita BC-601), neurodynamic parameters (“NS-PsychoTest”) were evaluated. Statistical analysis was performed using the application package Statistica 7.0 (StatSoft, USA).
Results. Students with different BMI levels did not differ significantly in body length. The differences in mean body weight of the examined students (with low and high BMI values) were due to the combined increase of fat mass (49.6%) and muscle mass (34.3%) in the males and the predominant increase of fat mass (96.7%) in the females, as well as to a decrease of body water content (by 23.4% in the females and 12.1% in the males). The neurodynamic characteristics of the students surveyed reflect statistically greater velocity-strength performance in young males, with less reliability in the executive systems of neurodynamic reactions. The obtained results indicate a strong correlation between morphotype and neurodynamic indices in students with low BMI (R=0,77; χ2=78,527, p=0,016), and a moderate strength relationship in the groups with medium and high BMI (R=0,64; χ2=84,688, p=0,036 and R=0,61; χ2=78,040, p=0,028 respectively).
Conclusion. Values of the morphological indices of the examined students reflect the prevalence of meso- and macrosomatotypes. There is a prevalence of anthropometric indices and higher velocity and force indices of neurodynamic in males in comparison with females. In the complex of morphological and neurodynamic processes, the studied students act as a heterogeneous group, the heterogeneity of which is due not only to age-sex-specific morphotype and neurodynamic, but also to their joint interdependence.
ANTIOXIDANT ACTIVITY OF DAIRY PRODUCTS FOR BABY FOOD
Authors: Vysokogorsky Valery E. , Rosenfeld Julia G. , Sokolova Maria A. 
Published: January 2023

Increasing the biological and nutritional value of breast milk substitutes by enriching different macro- and micronutrients is an important issue. To a certain extent, the nutritional value of milk is determined by its antioxidant activity.
The research aims to compare the antioxidant activity of dairy products for baby food and breast milk.
The current research studied cow pasteurized milk, drinking ultra-pasteurized “Tyoma,” sterilized milk for baby food “Agusha,” “NAN,” “Nutrilon,” and “Malyutka” milk mixtures, as well as breast milk of 17 women. The antioxidant activity was determined by the titrimetric permanganate method in aqueous and alcoholic milk extracts. The content of antioxidants in alcoholic extracts of milk and all dairy products significantly exceeds their levels in aqueous solutions. The content of water-soluble antioxidants in breast milk is significantly lower than in cow’s milk “Luzhaykino” and “Agusha,” but in infant formula, it corresponds to the indicators of breast milk. The level of alcohol-soluble antioxidants is lower in NAN and Nutrilon milk mixtures when compared with cow and breast milk. The milk mixture “Malyutka” does not differ from breast milk in terms of the antioxidant activity of alcohol- and water-soluble components.
Discussion. The use of separate determination of hydrophilic and hydrophobic antioxidants revealed significant differences between breast and cow’s milk. The enrichment of milk with easily destructible, water-soluble ascorbic acid did not affect the antioxidant activity of dairy products for baby food (“Agusha” and “Tyoma”).
The results obtained on the significant differences in the antioxidant properties of dairy products based on cow’s milk from breast milk indicate the need to optimize the composition of milk antioxidants for baby food and the creation of breast milk substitutes.
THE USE OF NATURAL ZEOLITES AS STATIONARY FILTERS FOR DISINFECTION AND PURIFICATION OF INDOOR AIR
Authors: Kondratyuk Elena V. , Maltseva Svetlana M. , Stroganov Dmitry A. , Ryabkova Elena A. , Trubina Irina S. 
Published: January 2023

In this study, from an ecological and hygienic point of view, the possibilities of using a natural mineral – zeolite – in indoor air filters are considered.
The purpose of the work: based on the analysis of the adsorbing and disinfecting properties of various types of air filters to show the undoubted advantages of stationary filters based on natural zeolites. As methods, the researchers relied on methods of comparative analysis, description and characteristics.
Results. Ventilation systems even in a small building are quite complex and require regular cleaning and disinfection. The study showed that the filters traditionally used for this purpose of absolute purification, bactericidal treatment or carbon filters have significant disadvantages (high cost, complexity of maintenance and disposal), while stationary filters based on natural zeolites, mined including in Russia, are inexpensive, hypoallergenic, easy to maintain, regenerable, have a disinfecting and deodorizing effect. However, today they are practically not used, and the technology of regeneration of natural zeolites for air filters has not yet been worked out, although such a possibility exists.
PECULIARITIES OF MORPHO-ANATOMICAL STRUCTURE OF GYPSYWORT (LYCOPUS EUROPAEUS L.) IN RESPONSE TO TREATMENT WITH SILICON-BASED MICROFERTILIZER
Authors: Savchenko Olga M. , Kovalev Nikita I. 
Published: January 2023

Background. For the comprehension the mechanisms of adaptation and increasing the bioproductivity of the Gypsywort, at the level of variability of micromorphological and anatomical features of the epidermis of the leaf plate and stem, it is proposed to study the reactions of plants to the use of micronutrients with adaptagenic properties.
Scientific originality. For the first time in the conditions of crop rotation, the adaptogenic effect of the micro-fertilizer Siliplant on the plants of the Gypsywort at the degree of the epidermal structures of the leaf and stem was shown and confirmed.
This work aim is to identify the morpho-anatomical features of Gypsywort, emerged as the result of exogenous treatment of plants with microfertilizer Siliplant.
Materials and methods. The Gypsywort’s plants, growing in the conditions of field crop rotation at the experimental field, were treated in the budding by micro-fertilizer Siliplant (0.055 gallons per acre). The control variant was treated with water. The consumption of the solution was 32,07 gallons per acre. The research material was collected under the second-year plants during the mass flowering phase. Leaf plates of the middle part of the shoots (10 pcs.) were taken from plants (5 pcs. of each variant). The anatomical method of analysis included microscopy and microphotography. A 9x Ernst Zeits Wetzlar light microscope and a 14.0 Mp USB 2.0 C-Mount camera were used for the study. The sample consisted of 10 measurements, statistical processing of the results was performed in Microsoft Excel. For each studied trait, its average value (M), the error of the mean (m) and the coefficient of variation (Cv%) were determined.
Results. The number and size of stomata were determined, the classification of trichomes was refined, their distribution, the density of pubescence and the number of essential oil glands were studied explored depending on the treatments of plants with Si-based microfertilizer. It has been found out that in plants growing in the field practically do not have hydathodes and pubescence increases.
Conclusion. Treatment of plants with silicon Si-based microfertilizer contributes to their adaptation to xeromorphic conditions: pubescence decreases, the number of essential oil glands increases, the growth of the bark and xylem elements intensifies. The increased number of stomates and their sizes in the variant with silicon-containing microfertilizer, compared to the control samples indicates its anti-stress effect on the gypsywort plants. The established features of the anatomical structure of plants can also be important in determining the authenticity of medicinal raw materials of Lycopus europaeus L. plants during microscopic analysis.
Analysis of Frequency Adjustable Control of Permanent Magnet Synchronous Motor for Pump-controlled Actuators
Authors: Zakharov Viacheslav , Minav Tatiana 
Published: January 2023

Recently the pump-controlled system has actively been proposed as a replacement for conventional valve-controlled systems, to improve the energy efficiency in non-road mobile machinery. Earlier research demonstrated that a pump-controlled hydraulic system combines the best properties of traditional hydraulics and electric intelligence. This pump-controlled system can be realized via direct control of hydraulic pimp/motor by varying speed of electric motor without complex servo valves. Nowadays, a wide range of different electric motors is known and available with efficiency higher than 95% One of the most attractive option of electric motor is Permanent Magnet Synchronous Motor (PMSM) due to its size, power, and high efficiency.
However, control of electric motors in pump-controlled systems has are not yet considered and not well researched.
In this paper, the main objective of this investigation is determination of control values for the pump-controlled actuator and analysis of system’s behavior in different applications.
Therefore, model of PMSM drive with pump-emulated load is proposed. Field Oriented Control (FOC) gives wide range of the speed regulation and smooth characteristics, but tuning of controllers is challenging.
Case of the steering-modeled load represented that such operations need more power than other modes. More complex frequency converters allow to reach higher level of accuracy and decrease torque ripples, but complexity of such systems increases rapidly.
Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner
Authors: Kurose Shun , Matsubara Yutaka , Yoshino Shinichiro , Yoshiya Keiji , Morisaki Koichi , Furuyama Tadashi , Hoshino Tomoaki , Yoshizumi Tomoharu 
Published: January 2023

AbstractMacrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐1 family, which binds to IL‐36 receptor (IL1RL2) and has an anti‐inflammation effect. Because macrophages express IL1RL2, we hypothesized that IL‐38 suppresses AAA formation by controlling macrophages. We assessed a C57BL6/J mouse angiotensin II‐induced AAA model with or without IL‐38 treatment. RAW 264.7 cells were cultured with tumor necrosis factor‐α and treated with or without IL‐38. Because p38 has important roles in inflammation, we assessed p38 phosphorylation in vitro and in vivo. To clarify whether the IL‐38 effect depends on the p38 pathway, we used SB203580 to inhibit p38 phosphorylation. IL1RL2+ macrophage accumulation along with matrix metalloproteinase (MMP)‐2 and ‐9 expression was observed in mouse AAA. IL‐38 reduced the incidence of AAA formation along with reduced M1 macrophage accumulation and MMP‐2 and ‐9 expression in the AAA wall. Macrophage activities including inducible nitric oxide, MMP‐2, and MMP‐9 production and spindle‐shaped changes were significantly suppressed by IL‐38. Furthermore, we revealed that inhibition of p38 phosphorylation diminished the effects of IL‐38 on regulating macrophages to reduce AAA incidence, indicating the protective effects of IL‐38 depend on the p38 pathway. IL‐38 plays protective roles against AAA formation through regulation of macrophage accumulation in the aortic wall and modulating the inflammatory phenotype. Using IL‐38 may be a novel therapy for AAA patients.
Assessing the commutability of candidate reference materials for the harmonization of neurofilament light measurements in blood
Authors: Andreasson Ulf , Gobom Johan , Delatour Vincent , Auclair Guy , Noam Yoav , Lee Stephen , Wen Jason , Jeromin Andreas , Arslan Burak , Maceski Aleksandra , Willemse Eline , Zetterberg Henrik , Kuhle Jens , Blennow Kaj 
Published: January 2023

Abstract

Objectives
Neurofilament light chain (NfL) concentration in blood is a biomarker of neuro-axonal injury in the nervous system and there now exist several assays with high enough sensitivity to measure NfL in serum and plasma. There is a need for harmonization with the goal of creating a certified reference material (CRM) for NfL and an early step in such an effort is to determine the best matrix for the CRM. This is done in a commutability study and here the results of the first one for NfL in blood is presented.

Methods
Forty paired individual serum and plasma samples were analyzed for NfL on four different analytical platforms. Neat and differently spiked serum and plasma were evaluated for their suitability as a CRM using the difference in bias approach.

Results
The correlation between the different platforms with regards to measured NfL concentrations were very high (Spearman’s ρ≥0.96). Samples spiked with cerebrospinal fluid (CSF) showed higher commutability compared to samples spiked with recombinant human NfL protein and serum seems to be a better choice than plasma as the matrix for a CRM.

Conclusions
The results from this first commutability study on NfL in serum/plasma showed that it is feasible to create a CRM for NfL in blood and that spiking should be done using CSF rather than with recombinant human NfL protein.
On the splitting conjecture in the hybrid model for the Riemann zeta function
Authors: Heap Winston 
Published: January 2023

Abstract
We show that the splitting conjecture in the hybrid model of Gonek, Hughes and Keating holds to order on the Riemann hypothesis. Our results are valid in a larger range of the parameter X which mediates between the partial Euler and Hadamard products. We also show that the asymptotic splitting conjecture holds for this larger range of X in the cases of the second and fourth moments.