bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conventional Non‐Fluorescent Polymers: Unconventional Security Inks for Data Storage and Multidimensional Photonic Cryptography
Authors: Ling Yao , Liu Jie , Dong Yu , Chen Yuanyuan , Chen Jiamao , Yu Xiaolan , Liang Baoshuai , Zhang Xiaocheng , An Wei , Wang Donghui , Feng Shiyu , Huang Weiguo 
Published: June 2023

AbstractTraditional security inks relying on fluorescent/phosphorescent molecules are facing increasing risks of forgery or tampering due to their simple readout scheme (i.e., UV‐light irradiation) and the advancement of counterfeiting technologies. In this work, a multidimensional data‐encryption method based on non‐fluorescent polymers via a “lock–key” mechanism is developed. The non‐fluorescent invisible polymer inks serve as the “lock” for data‐encryption, while the anti‐rigidochromic fluorophores that can distinctively light up the polymer inks with programed emissions are “keys” for decryption. The emission of decrypted data is prescribed by polymer chemical structure, molecular weight, topology, copolymer sequence, and phase structure, and shows distinct intensity, wavelength, and chirality compared with the intrinsic emission of fluorophores. Therefore, the data is triply encrypted and naturally gains a high‐security level, e.g., only one out of 20 000 keys can access the only correct readout from 40 000 000 possible outputs in a three‐polymers‐based data‐encryption matrix. Note that fluorophores lacking anti‐rigidochrimism cannot selectively light up the inks and fail in data‐decryption. Further, the diverse topologies, less well‐defined structures, and random‐coiled shapes of polymers make it impossible for them to be imitated. This work offers a new design for security inks and boosts data security levels beyond the reach of conventional fluorescent inks.
Dual‐Site W‐O‐CoP Catalysts for Active and Selective Nitrate Conversion to Ammonia in a Broad Concentration Window
Authors: Chang Ziwei , Meng Ge , Chen Yafeng , Chen Chang , Han Shuhe , Wu Ping , Zhu Libo , Tian Han , Kong Fantao , Wang Min , Cui Xiangzhi , Shi Jianlin 
Published: June 2023

AbstractEnvironmentally friendly electrochemical reduction of contaminated nitrate to ammonia (NO3−RR) is a promising solution for large quantity ammonia (NH3) production, which, however, is a complex multi‐reaction process involving coordination between different reaction intermediates of nitrate reduction and water decomposition‐provided active hydrogen (Hads) species. Here, a dual‐site catalyst of [W‐O] group‐doped CoP nanosheets (0.6W‐O‐CoP@NF) has been designed to synergistically catalyze the NO3−RR and water decomposition, especially the reactions between the intermediates of NO3−RR and water decomposition‐provided Hadsspecies. This catalytic NO3−RR exhibits an extremely high NH3yield of 80.92 mg h−1cm−2and a Faradaic efficiency (FE) of 95.2% in 1 mKOH containing 0.1 mNO3−. Significantly, 0.6W‐O‐CoP@NF presents greatly enhanced NH3yield and FE in a wide NO3−concentration ranges of 0.001–0.1 mcompared to the reported. The excellent NO3−RR performance is attributed to a synergistic catalytic effect between [W‐O] and CoP active sites, in which the doped [W‐O] group promotes the water decomposition to supply abundant Hads, and meanwhile modulates the electronic structure of Co for strengthened adsorption of Hadsand the hydrogen (H2) release prevention, resultantly facilitating the NO3−RR. Finally, a Zn‐NO3−battery has been assembled to simultaneously achieve three functions: electricity output, ammonia production, and nitrate treatment in wastewater.
Plasmonic Nanotags for On‐Dose Authentication of Medical Tablets
Authors: Fukuoka Takao , Yasunaga Toshiya , Namura Kyoko , Suzuki Motofumi , Yamaguchi Akinobu 
Published: June 2023

AbstractPlasmonic nanomaterials have attracted much attention to new anticounterfeiting technology. Since one of current anticounterfeiting problems is fake medical tablets, on‐dose authentication of the tablets is strongly required considering tiny area of tablets, biocompatibility, and long shelf life. Previously, Nanotags consisting of self‐assemblies of colloidal gold nanoparticles with reporter molecules were proposed, which produce characteristic surface enhanced Raman scattering (SERS) activity. However, long‐term stability is rarely discussed for SERS active nanostructures. This study deposits about 10 ng of the Nanotags on a very tiny area of the commercial tablets. Distinguishable SERS signals of reporting molecules are confirmed by 1s irradiation of 785 nm laser over the Nanotags, while Raman spectrum of the ingredients is observed on the tablet without the Nanotags. Rapid authentication of tablets stocked over 8 years is sufficiently carried out. In addition, the Nanotags on the tablets are almost invisible to the eye, in particular, if the tablet surface is uneven or colored. It is considered that the presence of discrete AuNP assemblies allows excellent performances of Nanotag.
Roll‐To‐Roll Fabricating MXene Membranes with Ordered Interlayer Distances For Molecule And Ion Separation
Authors: Li He , Liu Huiquan , Shi Changrui , Qin Jiawen , Fu Yixuan , Song Yongchen , Li Yanghui , Ling Zheng 
Published: June 2023

AbstractApplication‐oriented assembly of two‐dimensional nanosheets with uniform nanochannels is critical for fabricating sophisticated, high‐performance membranes for water treatment. However, fabricating the desired membranes by a simple, fast, and effective method is a challenge as most of the previous methods are based on batch processes rather than a continuous roll‐to‐roll process. Here, a simple Meyer rod‐coating approach to continuously fabricate large‐size and flat MXene membranes at a scale up to 5 m is introduced. This study demonstrated that a high MXene concentration, above 10 mg mL−1, is critical in processability due to the desired viscosity, surface tension, and viscoelastic properties. The as‐made MXene membranes show that shearing and solutal‐Marangoni flow can considerably improve the ordering of the stacked MXene nanoflakes. Thus, the rod‐coated MXene membranes demonstrate a smaller surface roughness and interlayer distance compared to the MXene membranes fabricated by the most commonly vacuum‐assisted filtration. The rod‐costed MXene membranes show superior performance in dye and mono/divalent cation separation. The proposed roll‐to‐roll Meyer rod‐coating method can also be used to fabricate MXene‐based composites, such as MXene/carbon nanotubes and MXene/polymer, using the inks containing high concentration MXene and other desired compositions. This roll‐to‐roll method will promote an industry‐level fabrication and application of MXene‐based membranes.
Continuous Synthesis of Epoxides from Alkenes by Hydrogen Peroxide with Titanium Silicalite‐1 Catalyst Using Flow Reactors
Authors: Kon Yoshihiro , Nakashima Takuya , Makino Yoshiki , Nagashima Hiroki , Onozawa Shun‐ya , Kobayashi Shū , Sato Kazuhiko 
Published: June 2023

AbstractAbstract. Continuous‐flow epoxidation of aliphatic and aromatic alkenes with hydrogen peroxide (H2O2) was carried out to give epoxides using a fixed‐bed liquid flow reactor equipped with a solid titanium silicalite‐1 (TS‐1) catalyst column. The developed flow reaction enables continuous synthesis of 4‐phenyl‐1,2‐epoxybutane from 4‐phenyl‐1‐butene in 90%–98% yields (22.4 g) for 150 h from a catalyst column of 5 mm inner diameter with 100 mm length. Employment of a mixed solution of MeCN and MeOH with preservation of the Ti active site in TS‐1 crystal structures with few defects permits continuous epoxidation of less‐reactive long‐chain terminal alkene and multifunctional alkene to give epoxides in 12%–98% yields with 78%–99% selectivity.
FGF19‐Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer
Authors: Li Chen , Chen Tianli , Liu Jialiang , Wang Yue , Zhang Chunhuan , Guo Lu , Shi Dandan , Zhang Tingguo , Wang Xishan , Li Jie 
Published: June 2023

AbstractLiver metastasis is the main cause of death in patients with colorectal cancer (CRC); thus, necessitating effective biomarkers and therapeutic targets for colorectal cancer liver metastasis (CRLM). Fibroblast growth factor 19 (FGF19) is a protumorigenic gene in numerous human malignancies. In this study, it is shown that FGF19 plays an indispensable role in CRLM. FGF19 expression and secretion are markedly correlated with liver metastasis and lower overall survival rates of patients with CRC. An in vivo metastasis model shows that FGF19 overexpression confers stronger liver‐metastatic potential in CRC cells. Mechanistically, FGF19 exerts an immunomodulatory function that creates an environment conducive for metastasis in CRLM. FGF19 mediates the polarization of hepatic stellate cells to inflammatory cancer‐associated fibroblasts (iCAFs) by activating the autocrine effect of IL‐1α via the FGFR4‐JAK2‐STAT3 pathway. FGF19‐induced iCAFs promote neutrophil infiltration and mediate neutrophil extracellular trap (NET) formation in liver metastatic niches via the production of complement C5a and IL‐1β, which in turn accelerates the liver colonization of CRC cells. Importantly, targeting FGF19 signaling with fisogatinib efficiently suppresses FGF19‐induced liver metastasis in a mouse model. In summary, this study describes the mechanism by which FGF19 regulates CRLM, thereby providing a novel target for CRLM intervention.
A General and Efficient Strategy for Gene Delivery Based on Tea Polyphenols Intercalation and Self‐Polymerization
Authors: Chen Hao , Guo Lina , Ding Jinsong , Zhou Wenhu , Qi Yan 
Published: June 2023

AbstractGene therapy that employs therapeutic nucleic acids to modulate gene expression has shown great promise for diseases therapy, and its clinical application relies on the development of effective gene vector. Herein a novel gene delivery strategy by just using natural polyphenol (‐)‐epigallocatechin‐3‐O‐gallate (EGCG) as raw material is reported. EGCG first intercalates into nucleic acids to yield a complex, which then oxidizes and self‐polymerizes to form tea polyphenols nanoparticles (TPNs) for effective nucleic acids encapsulation. This is a general method to load any types of nucleic acids with single or double strands and short or long sequences. Such TPNs‐based vector achieves comparable gene loading capacity to commonly used cationic materials, but showing lower cytotoxicity. TPNs can effectively penetrate inside cells, escape from endo/lysosomes, and release nucleic acids in response to intracellular glutathione to exert biological functions. To demonstrate the in vivo application, an anti‐caspase‐3 small interfering ribonucleic acid is loaded into TPNs to treat concanavalin A‐induced acute hepatitis, and excellent therapeutic efficacy is obtained in combination with the intrinsic activities of TPNs vector. This work provides a simple, versatile, and cost‐effective gene delivery strategy. Given the biocompatibility and intrinsic biofunctions, this TPNs‐based gene vector holds great potential to treat various diseases.
The Emergence of 2D Building Units in Metal‐Organic Frameworks for Photocatalytic Hydrogen Evolution: A Case Study with COK‐47
Authors: Ayala Pablo , Naghdi Shaghayegh , Nandan Sreejith P. , Myakala Stephen Nagaraju , Rath Jakob , Saito Hikaru , Guggenberger Patrick , Lakhanlal Lakhanlal , Kleitz Freddy , Toroker Maytal Caspary , Cherevan Alexey , Eder Dominik 
Published: June 2023

AbstractMetal‐organic frameworks (MOFs) are promising materials for photocatalytic water splitting reactions, but examples of visible light‐responsive, catalytically active, and stable MOFs are still rare. A detailed investigation is conducted for COK‐47 – a recently described MOF comprising 2D Ti‐O6 secondary building units (SBUs) – toward a photocatalytic hydrogen evolution reaction (HER), showing how overall particle morphology, surface area, and missing ligand defects are central parameters governing the material's ultimate performance. The newly synthesized COK‐47ISO is among the most active MOFs to date, yielding HER‐rates of 8.6 µmol h−1, and an apparent quantum yield (AQY) of 0.5% under visible light illumination. Optoelectronic and photoluminescence investigations, supported by theoretical calculations, enable the unraveling of its electronic structure along with charge transfer and recombination kinetics. A wavelength‐dependent reaction mechanism is proposed involving ligand to metal charge transfer (LMCT) and the main challenges for visible or UV photoexcitation are identified, demonstrating that the unique 2D layered structure aids charge separation and is key to the high performance. This work introduces COK‐47 as a promising alternative to the well‐known MIL‐125 family and offers directions for future studies
Probing the Multiexcitonic Dynamics in CsPbI3 Nanocrystals across the Temperature‐Induced Reversible Phase Transitions
Authors: Liu Siyu , Geng Huifang , Geng Huaxiu , Huang Zhuanzhuan , Deng Shibin , Shen Xi , Yu Richeng , Zheng Kaibo , Canton Sophie E. , Fu Xuewen 
Published: June 2023

AbstractCsPbI3 nanocrystals (CPI NCs) have become a trending research topic due to their impressive potential in functional optoelectronic devices and optical gain applications. Their optical responses are governed by carrier dynamics, which is greatly influenced by temperature and corresponding phase structure due to the effects of inherently electron‐phonon coupling. Notably, CPI NCs have been identified to adopt an unexpectedly stable cubic phase from room temperature to liquid helium temperature. Here, using in situ cryogenic electron diffraction measurements, it is unambiguously demonstrated that CPI NCs undergo consecutive cubic‐tetragonal‐orthorhombic phase transitions from 298 to 100 K. The corresponding temperature‐dependent multiexcitonic dynamics are investigated in each phase by combining time‐resolved photoluminescence and transient absorption spectroscopy. In addition to the temperature dependency, the lifetime of both excitons and biexcitons evidently depends on the phase structures of the CPI NCs, highlighting the crucial effect of crystal structure on the carrier dynamics. Moreover, the biexciton binding energy increases with higher crystal symmetry due to the decrease of the dielectric constant. The findings shed light on the structural phase transition and its relationship to the carrier dynamics in all‐inorganic perovskite NCs, which provides critical insight into the structure‐performance relationship in CPI NCs for promising applications in optoelectronic devices.
Quantifying molecular surface barriers and intracrystalline diffusion in nanoporous materials by zero‐length column
Authors: Xie Yiwei , Li Hua , Lou Caiyi , Ye Mao , Liu Zhongmin 
Published: June 2023

AbstractThe zero‐length column (ZLC) method has been frequently used to measure the effective diffusivity of guest molecules in nanoporous crystalline materials. Recent studies unveiled that the mass transport of guest molecules could originate from either intracrystalline diffusion and/or surface barriers. Directly quantifying the intracrystalline diffusivity and surface permeability of guest molecules. therefore, is essential for understanding the mass transfer and thus optimizing the design of nanoporous crystalline materials. In this work, we extended the ZLC method, based on a derived theoretical expression of the desorption rate, to decouple the surface barriers and intracrystalline diffusion from effective diffusion of guest molecules in nanoporous materials. The diffusivities of ethane, propane and n‐pentane in SAPO‐34 and Beta zeolites have been experimentally measured to verify the effectiveness of this method.
Human cold adaptation: An unfinished agenda v2.0
Authors: Ocobock Cara 
Published: June 2023

AbstractBackgroundResearch on human extreme cold climate adaptations has benefitted from a recent resurgence since Ted Steegmann laid out his Human Cold Adaptation Agenda in 2007. Human biologists have drastically expanded our knowledge in this area during the last 15 years, but we still have a great deal more work to do to fulfill the cold climate adaptation agenda.MethodsHere, I follow Steegmann's example by providing a review of cold climate adaptations and setting forth a new, expanded agenda.ResultsI review the foundational work on cold climate adaptations including classic Bergmann, Allen, and Thomson rules as well as early work assessing metabolic differences among Indigenous cold climate populations. From there, I discuss some of the groundbreaking work currently taking place on cold climate adaptations such as brown adipose tissue (a heat generating organ), physical activity levels, metabolic rates, and behavioral/cultural mechanisms. Finally, I present a path forward for future research with a focus on some of the basic extreme cold adaptations as well as how human biologists should approach the effects of climate change on human health and well‐being, particularly within a cold climate context.ConclusionThe Arctic has felt the dramatic effects of climate change sooner and more acutely than other parts of the world, making it an ideal location for studying both cold climate adaptations and climate change resilience. Human biologists have a great deal to contribute to the conversation on not only adaptations to extreme cold, but also the ways in which climate change is being embodied by cold climate populations.
Halogen‐Bond‐Promoted Hydroxyperfluoroalkylation of Olefins with Molecular Oxygen under Visible‐Light Irradiation
Authors: Tagami Koto , Yajima Tomoko 
Published: June 2023

AbstractFluorinated organic compounds are indispensable, and the development of perfluoroalkylation reaction is an important topic of concern. In this paper, we present the generation of an amine‐promoted visible‐light‐induced hydroxyperfluoroalkylation reaction of olefines using molecular oxygen as a hydroxy source. This reaction is caused by the formation of perfluoroalkyl radicals due to visible‐light irradiation to halogen‐bonded complex of a tertiary amine and a perfluoroalkyl iodide. This transformation is applicable for various types of electron‐deficient olefins and styrene, and various fluoroalkyl iodides are acceptable as well. This visible‐light induced, metal‐free reaction using inexpensive and readily available reagents is a sustainable method for the synthesis of fluorine‐containing compounds.
Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites
Authors: Murao Takuya , Kouzaki Hideaki , Arai Hiroyuki , Matsumoto Koji , Nakamura Keigo , Kawakita Kento , Tojima Ichiro , Shimizu Shino , Yuta Atsushi , Shimizu Takeshi 
Published: June 2023

AbstractBackgroundAllergic rhinitis (AR) impairs quality of life and affects nearly 40% of the Japanese population. Sublingual immunotherapy (SLIT) is the disease‐modifying treatment for AR, but requires the selection of a biomarker associate with clinical efficacy in patients with AR who are treated with SLIT. The present study sought to examine objective biomarkers used for assessing the clinical efficacy of SLIT.MethodsThe authors examined the effects of 1 year of SLIT treatment with house dust mites (HDMs) using peripheral blood mononuclear cells (PBMCs) and serum from patients with AR. The prevalences of follicular regulatory T (Tfr), type 2 follicular helper T (Tfh2), type 2 helper T (Th2), conventional regulatory T (Treg), and type 1 regulatory T (Tr1) cells were examined by flow cytometry. Serum concentrations of HDM‐specific IgA, IgE, and IgG4 antibodies, and HDM‐induced production of interleukin (IL) 5 and IL‐10 from cultured PBMCs were evaluated by enzyme‐linked immunosorbent assay.ResultsFollowing 1 year of SLIT, the prevalences of Tfr, conventional Treg, and Tr1 cells were significantly increased, whereas that of Th2 cells and Tfh2 cells were significantly decreased; the serum concentration of HDM‐specific IgG4 was significantly increased; and HDM‐induced production of IL‐5 from PBMCs was significantly decreased, while that of IL‐10 was significantly increased. The increase in the prevalence of Tfr cells after SLIT correlated positively with the improvement of clinical symptom scores.ConclusionAn increase in Tfr cells may play an important role in SLIT, and may be a useful indicator for the clinical efficacy of SLIT.
EarlyMagnetic Resonance ImagingFeatures of New Paramagnetic Rim Lesions in Multiple Sclerosis
Authors: Clark Kelly A. , Manning Abby R. , Chen Luyun , Liu Fang , Cao Quy , Bar‐Or Amit , Shinohara Russell T. , Sweeney Elizabeth , Schindler Matthew K. 
Published: June 2023

ObjectiveTo determine early magnetic resonance imaging (MRI) features of new multiple sclerosis (MS) lesions that will develop into paramagnetic rim lesions (PRLs), which have been associated with progressive tissue injury in MS.MethodsNew contrast‐enhancing lesions observed on routine clinical MRI were imaged at 7 T within 4 weeks of observation, and 3 and 6 months later. The 6‐month MRI was used to classify PRL status (PRL or non‐PRL). The relationship between early lesion characteristics and subsequent PRL status was assessed using generalized linear mixed effects models. Random forest classification was performed to classify early predictors of subsequent PRL status.ResultsFrom 93 contrast‐enhancing lesions in 23 MS patients, 37 lesions developed into a PRL. In lesions that developed into PRLs compared with those that did not, the average lesion T1on the initial 7 T MRI was 1994 ms compared with 1,670 ms (p‐value <0.001), and the average volume was 168.7 mL compared with 44 mL (p‐value <0.001) in lesions that did not. These volume differences were also found on 3 T scans (p‐value <0.001), and for intensity‐normalized T1‐w (p‐value = 0.011) and fluid‐attenuated inversion recovery (p‐value = 0.005). The area under the receiver operating characteristic curve for the random forest classification with leave‐one‐out cross‐validation was found to be 0.86 using initial 7 T features.InterpretationNew MS lesions that evolve into PRLs can be identified early in lesion evolution. These findings suggest that biological mechanisms underlying PRL development begin early, which has important implications for clinical trials targeting PRLs development and subsequent therapeutics. ANN NEUROL 2023;94:736–744
Eggshell integrated GelMA/CSMA/HyMA hybrid hydrogels for cell therapy/tissue engineering
Authors: Yüce‐Erarslan Elif , İzbudak Burçin , Kızılkurtlu Ahmet Akif , Topal Merve , Akpek Ali , Bal‐Öztürk Ayça 
Published: June 2023

AbstractThe use of biocompatible materials with improved behaviors for potential applications in the area of tissue engineering has increased as the developments in biomaterials have increased in recent years. Current approaches concentrate on hybrid combinations of synthetic and natural polymers. In this context, obtaining porous scaffolds with good mechanical properties is still challenging. Herein, a hybrid tissue scaffold consisting of methacrylated gelatin (GelMA), methacrylated chondroitin sulfate (CSMA), methacrylated hyaluronic acid (HyMA) and eggshell particles with enhanced pore morphology and mechanical property was fabricated by photo‐polymerization. The effect of different amounts of eggshell particles on the behaviors of hybrid hydrogel scaffolds was investigated. It was determined by scanning electron microscope analysis (SEM) that the particles were well‐dispersed and triggered the formation of an interconnected porous structure in the hybrid tissue scaffold containing 10% by weight of eggshell particles. It was concluded that the mechanical behaviors of the hybrid tissue scaffold containing 10% by weight of eggshell particles improved by 47% compared to the neat hydrogel scaffold. There were no toxic effects of eggshell particles‐integrated scaffolds against osteoblast cells. In addition, cells successfully adhered onto the scaffolds and proliferated. Consequently, GelMA/CSMA/HyMA scaffolds containing 10% eggshell particles were found to be biocompatible and suitable for cell therapy and tissue engineering applications.