bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital-based Entrepreneurship Training to Realize Young Entrepreneurial Millennials
Authors: Alhusin* Syahri , Widodo Zandra Dwanita , Choerudin Achmad , Zaelani Abdullah , Wijastuti Sri , Adiyani Rini , Rahmalia Vidia 
Published: May 2023

Being an entrepreneur is an attempt of activating Indonesian economic wheel. In the attempt of empowering creativity and innovation, the entrepreneurs are expected to grow into employers who can open job opportunities in various business sectors. This community service activity is entitled a digital-based entrepreneurship training to realize millennial generation with young entrepreneur spirit. This title was chosen based on the factual condition of people today characterized with the increased unemployment rate disproportional to the job opportunity availability. The problems encountered by participants are limited information and experience supporting the digital-based entrepreneurial activities, and limited knowledge on the detail of digital-based entrepreneurship, leading to the limited number of alumni and graduates choosing to be entrepreneurs. This activity aims to improve skill and to create digital-based young entrepreneurs to the participants in the partner location. The basic output with target to be achieved is the created independent business community having digital-based entrepreneurial skill. This community service was implemented in the form of entrepreneurship training and facilitation. The partner in this activity includes the students of Faculty of Business Economy of Universitas Tunas Pembangunan (UTP) Surakarta. Twenty (20) participants participated in this activity. Evaluation was conducted using questionnaire distributed to the participants aiming to find out the students’ understanding on the implementation of training and interview. The result achieved in the end of community service activity is the improved understanding and skill of participants concerning digital-based entrepreneurship that can be indicated with the number of startups established by the participants.
The impact of Covid-19 On Micro Small Medium Enterprises (UMKM) in Tanjung Morawa Deli Serdang North Sumatera
Authors: Nainggolan* Lya Novaria , Lubis Irsad , Tanjung Ahmad Albar , Sukardi Sukardi , Ruslan Dede 
Published: May 2023

The Covid-19 virus is a deadly virus that is faced by almost all countries, without exception, in various parts of Indonesia. Our country Indonesia has been greatly affected by the spread of Covid-19. Various kinds of new variants are coming back, namely the Covid-19 variant of Delta, which forces the government to act quickly even though sometimes it's not right. All forms of policies are taken to suppress the spread of the virus. We call it Lock Down, Large-Scale Social Restrictions (PSBB), Micro-Scale Social Restrictions, there is also the Enforcement of Restrictions on Community Activities (PPKM in all provinces and DKI). Apart from health and mortality rates, Covid-19 does not also affect the economy. The middle to lower class society is greatly affected by this condition. Therefore, this research will review the impact of COVID-19 on the economic conditions of UMKM in the Tanjung Morawa area, Deli Serdang. The data collection process was carried out by means of interviews with several traders selling around the Tanjung Morawa Market area and documentation then carried out a qualitative descriptive research method approach. The results of this study show that there is a significant impact of the covid19 pandemic on UMKM.
Port Closure Due to the Covid-19 Pandemic in the Law of Carriage of Goods By Sea and Unidroit Principles of International Commercial Contracts
Authors: Misridaputri* Syifa Salsabila , Ikhwansyah Isis , Trisnamansyah Purnama 
Published: May 2023

Port closure as an effort to slow the spread of the Covid-19 virus has had various impacts, such as port congestion which has led to delays and drastically increased transportation costs. This study examines the impacts caused by port closures and legal remedies that can be taken based on international sea transport law. Losses due to port closures cannot be borne by the carrier based on the conventions of sea shipping law as long as the carrier can prove that the fault was not his own. The closure of the port can be categorized as a hardship, in which there are fundamental changes that affect the agreement, namely the increase in shipping costs and delays. efforts that can be made based on the UPICC are renegotiation, and if it fails, the parties can seek a dispute settlement through the courts. In implementing the agreement, the parties must prioritize the principle of good faith and prove that the losses incurred and losses did not originate from themselves.
Evaluation of Online Learning for PGSD Study Program Students Using the CIPP Model
Authors: Akbar* Azaz , Syamsurijal Syamsurijal 
Published: May 2023

Penelitian ini bertujuan untuk mengukur evektifitas pembelajaran daring pada mata kuliah pengelolaan perpustakaan prodi pendidikan guru sekolah dasar. Metode yang digunakan adalah deskriptif kualitatif dengan pendekatan evaluasi CIPP yang dikembangkan oleh Stuflebeam. Hasil evaluasi kontek program perkuliahan sistem daring termasuk dalam kategori sangat baik dengan prosentase tiga item pertanyaan yakni media dan sarpras, kebutuhan, dan lingkungan belajar mendapatkan skor tertinggi yakni 90% dengan rata-rata 30%. Hasil evaluasi input dari empat item pertanyaan yang mendapat jawaban dominan yakni baik dengan total 190.66 % atau dengan rerat 47,666%. Hasil evaluasi Proses program perkuliahan sistem daring termasuk dalam kategori baik dengan prosentase setuju sebesar 168,76% dengan rata-rata 42,19 %. Hasil evaluasi Produk program perkuliahan sistem daring termasuk dalam kategori baik dengan prosentase setuju lebih dominan yakni dari dua item pertanyaan mendapatkan kumulusi penilaian sebesar 95% atau dengan rata-rata 47.5 %.
The Provision of Lend Based on Collateral in the Form of Inherited Objects on Behalf of the Heirs in Relation to the Principle of Legal Certainty
Authors: Alensia* Melysa Putri , Lunandi Yenny Yuniawaty 
Published: May 2023

Financial limitations to make ends meet, allow everyone to borrow some money from individuals and banking institutions. In granting credit to debtors, the bank requires the debtor to provide collateral. In practice, there is land and/or buildings which are objects of inheritance on behalf of the testator which are used as collateral when applying for credit to the bank. This study aims to understand and examine legal certainty for banks as creditors if the debtor uses the object of inheritance as collateral in applying for credit. In this study the authors used a legal research method that used a normative juridical research type, namely research that was intended to conduct a study of the application of rules or norms in positive law. The data source used by the author in this study is secondary data obtained from library research. The results of the research show that collateral is an important requirement in granting credit. Collateral is the bank's belief in the ability and ability of the debtor to pay off his debt obligations according to the agreement, so that the bank should have strict criteria for receiving guarantees from the debtor. behind the first name on behalf of the heirs in order to provide legal certainty for the bank as a creditor.
The Effect of Non-Performing Loans (NPL) to the Bank Profitability During the Covid-19 Pandemic (Case Study of Buku III Bank in Indonesia)
Authors: Rusli* Moch. , Fitriana Aning 
Published: May 2023

Bank is a financial institution that functions as a liaison between parties who have excess funds and those who need funds. In creating bank health, it is measured by profitability indicators to see the ability to increase profits, measure effectiveness and efficiency in management. Its profitability can be seen from the value of ROA (Return On Assets) and ROE (Return On Equity). The banking industry has problems in bad debtors which can be seen from the value of NPL (Non-Performing Loan) and this is exacerbated by special conditions that have occurred in recent years, namely the Covid-19 pandemic. So it is necessary to see how the effect of non-performing loans on bank profitability during the Covid-19 pandemic and this study conducted a case study on Buku III banks in Indonesia represented by 7 banks that reported financial data from 2019-2021, namely Bank HSBC Indonesia, Bank Tabungan Negara, Bank DBS Indonesia, Bank Permata, Bank Mega, Bank DKI, and Maybank Indonesia. The results show that the results of the analysis using SPSS version 25, partially non-performing loans represented with NPLs have no effect on the profitability of banks represented with ROA and ROE. Meanwhile, the same condition occurs in the results of the analysis test simultaneously or together with non-performing credit variables, namely NPLs, do not affect bank profitability, namely ROA and ROE.
Makna Warna Tata Rias Wajah Pemain Kabuki pada Video Shibaraku
Authors: Ni Nyoman Sariyanti  , Meidariani Ni Wayan , Nurita I Wayan 
Published: May 2023

Tulisan ini bertujuan untuk mengetahui makna warna tata rias wajah seni pertunjukan kabuki pada karakter antagonis, protagonis dan karakter Putri pada video Shibaraku. Analisis makna menggunakan teori semiotika Peirce melalui klasifikasi jenis tanda yang dilihat dari objeknya yaitu ikon berupa gambar tokoh kabuki, indeks berupa warna dan jenis riasan yang digunakan tokoh kabuki dan simbol berupa hubungan warna dengan karakter tokoh kabuki. Klasifikasi tanda tersebut telah digunakan untuk memaknai warna dalam tata rias wajah kabuki. Sumber data yang digunakan pada tulisan ini merupakan sumber data primer berbentuk video pertunjukan kabuki berjudul Shibaraku yang diunduh dari YouTube. Metode yang digunakan pada tulisan ini ialah metode kualitatif. Berdasarkan hasil analisis data, makna dan nama riasan tokoh dapat diketahui, tata rias wajah karakter protagonis yaitu riasan kumadori sujiguma dengan warna merah yang memiliki makna kebaikan dan keadilan. Sebaliknya, tata rias wajah karakter antagonis yaitu riasan kumadori kugeare dengan warna biru yang memiliki makna dingin atau kejam. Lalu, tata rias karakter Putri yaitu riasan standar dengan warna dasar putih yang memiliki makna kemurnian karakter, dan merah tipis pada bagian mata yang memiliki makna feminim dan keceriaan.
Kata kunci: kabuki; makna; tata rias; warna.
The Importance of Medication Adherence in the Treatment of Actinic Keratosis: An Expert Consensus Panel
Authors: Zakria Danny , Armstrong April , Berman Brian , Del Rosso James , Lebwohl Mark , Schlesinger Todd , Rigel Darrell 
Published: May 2023

Background: Actinic keratosis (AK) is one of the most common dermatologic diagnoses. While there are several treatment options, many topical therapies have poor adherence due to duration of treatment and local skin reactions (LSRs).
Objective: To review the available literature on the most commonly used patient-administered field-directed therapies for AK and create consensus statements on the role of medication adherence in improving AK outcomes.
Methods: A literature search of PubMed was completed for English-language original research articles reporting efficacy, safety, and tolerability data for 5-FU, diclofenac gel, imiquimod cream, and tirbanibulin. Once the articles were selected, they were distributed to a panel consisting of seven dermatologists with extensive expertise in managing AKs. Each panelist reviewed the articles and assigned them a level of evidence based on Strength of Recommendation Taxonomy (SORT) criteria. The panelists then met to review and discuss the studies and created consensus statements on the management of AKs and the importance of medication compliance. A modified Delphi process was used to approve the adoption of each statement.
Results: The literature search produced 1,326 articles that met search criteria. After screening these articles for relevance and applying the inclusion criteria, 17 articles were chosen to be reviewed by the panel and assigned a level of evidence based on SORT criteria. The panel then created six consensus statements that received a unanimous vote for adoption.
Conclusion: While there are several options for the treatment of AK, there is little consensus on a standard of care. Clearance rates for the most common topical field therapies vary significantly but are also difficult to directly compare due to differences in methodology for measuring and assessing outcomes. Overall, it is clear that an efficacious, tolerable, and convenient treatment for AKs is critical to optimal adherence and management and, given the results of recent studies, tirbanibulin may be the best topical option for meeting these criteria.
Clinician- and Patient-Reported Outcomes with Tirbanibulin 1% Treatment for Actinic Keratosis in Routine Clinical Practice Across the U.S. (PROAK Study)
Authors: Schlesinger Todd , Kircik Leon , Del Rosso James , Rigel Darrell , Lebwohl Mark , Berman Brian , Armstrong April , Bhatia Neal , Patel Vishal A. , Narayanan Siva , Koscielny Volker , Kasujee Ismail 
Published: May 2023

Background: Patients' experiences regarding topical actinic keratosis (AK) treatments may optimize clinical outcomes. PROAK study aimed to evaluate patient- and clinician-reported outcomes among adult patients with AK on face or scalp who were prescribed tirbanibulin in real-world clinical practice in the United States.
Methods: Key primary endpoint was quality of life (QoL) assessed by Skindex-16. Additional endpoints were tirbanibulin treatment effectiveness and satisfaction (Treatment Satisfaction Questionnaire for Medication and Expert Panel Questionnaire).
Results: 290 patients were included in this analysis. At week 8, Skindex-16 scores improved in all domains (mean change from baseline [standard deviation, SD]: -14.3 [27.8] in symptoms, -24.9 [33.0] in emotions, and -9.8 [23.7] in functioning domain). Clinicians and patients reported high global satisfaction with tirbanibulin (mean [SD] scores of 78.8 [20.1] and of 74.5 [23.5]). Overall skin appearance improved from baseline to week 8 (91.0% clinicians; 84.1% patients). In comparison with previous treatments, tirbanibulin had shorter skin reactions duration (89.2% clinicians; 73.9% patients); milder skin reaction severity (91.0% clinicians; 76.6% patients); better daily activities impact (87.4% clinicians; 64.0% patients); and was easier to use (88.3% clinicians; 71.2% patients). Investigator’s Global Assessment (IGA) success (0-1) was achieved by 73.8% of the patients. Skin photodamage severity reduction from baseline to week 8 was significant (77.4% vs. 39.6%; p<0.0001).
Conclusions: Tirbanibulin treatment demonstrated effectiveness in AK management. Moreover, tirbanibulin improved QoL, as early as week 8, and both clinicians and patients reported tirbanibulin treatment convenience, and high levels of treatment satisfaction, compared to patient’s previous treatments.
Epidemiology and Mortality Risk Factors of Sebaceous Carcinoma: A SEER – Based Population Study
Authors: Haquang Joseph , Li Rocky , Mai Kevin , Chen Kuang Cheng , Sisan Fardad , YuLing Kuo 
Published: May 2023

Background:
Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. It is derived from the adnexal epithelium of sebaceous glands and tends to hold a diverse clinical presentation. Although it is often reported in the periocular region, it can manifest from any sebaceous unit in the skin. Due to the rarity of this condition, prognostic and demographic factors are largely indeterminate. Hence, we sought to assess the prognostic impact of demographic and socioeconomic factors on the outcome of patients with sebaceous carcinoma.

Methods:
A retrospective analysis was performed utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database. From the registries, cases of sebaceous carcinoma from the years 2000 to 2018 were analyzed. Univariate and multivariate cox regression analyses were used to analyze the significance of socioeconomic and demographic factors on the survival of sebaceous carcinoma. Tumor grade and extent were included in the multivariate cox regression to minimize confounding.

Results:
A total of 4154 cases of sebaceous carcinoma were analyzed within this study. Socioeconomic and demographic factors analyzed includes age, sex, race, and income. On multivariate analysis including tumor grade, tumor extent, age, sex, race and income, African American race was a significant risk indicator for survival (hazard ratio [HR], 1.9; P=.007). Increased age of 70+ were also identified as a significant risk indicator for survival (HR, 5.86; P<0.001). Female sex was identified as a protective indicator for survival (HR, 0.82; P=0.03). Income status did not significantly influence the survival outcome of sebaceous carcinoma.

Conclusion:
Although income status did not show any significant influence on the survival outcome of sebaceous carcinoma, sex, race, and age characteristics did. The etiology behind these prognostic factors is unclear but may be related to access to medical care or lack of social support.
The Prevalence of Secondhand Smoke Exposure in Hidradenitis Suppurativa: A Cross-Sectional Survey Study
Authors: Weir Sydney , Ahmed Hana , Broughton Mia , Kole Lauren 
Published: May 2023

Introduction
Hidradenitis Suppurativa (HS) is a chronic inflammatory disease of the skin highly associated with firsthand smoking. Secondhand smoke, defined as the inhalation of smoke from burning a tobacco product or smoke that is exhaled by smokers, and its relationship to HS has not been assessed. This study aims to determine the prevalence of secondhand smoke exposure in the HS population.
Methods
In this cross-sectional study (N=136), surveys were both administered in a dermatology clinic and emailed to patients with HS, verruca vulgaris (VV), and atopic dermatitis (AD). Control groups were selected based on secondhand smoke associations: AD has a known association, whereas VV does not.
Results
The survey response rate was 67.3% (N=136). We found that more than half of HS patients (58.73%) were exposed to secondhand smoke within the last 12 months, whereas 38.30% and 30.77% in the AD and VV groups were exposed, respectively (p=0.0209). Additionally, our data did not identify a significant correlation between secondhand smoke and HS disease severity.
Conclusion
Our study is the first to assess the prevalence of secondhand smoke exposure in the HS population. However, due to the limitations of the study design and significant differences between study groups, we were unable to assess the true association between HS and secondhand smoke exposure. While our study did not identify an increased prevalence of secondhand smoke exposure in the HS population, it highlights an area for further investigation evaluating the relationship between passive tobacco exposure and inflammatory skin disease.
Subtype performance of the ancillary diagnostic 23- and 35-gene expression profile (GEP) tests for difficult-to-diagnose melanocytic lesions
Authors: Plaza Jose A , Estrada Sarah I , Russell Brooke H , Siegel Jennifer J , Rogers Jason , Wilkinson Jeffrey K , Kurley Sarah J , Goldberg Matthew S , Motaparthi Kiran 
Published: May 2023

Background: Histopathological examination is adequate for most melanocytic neoplasms; however, there is a subset of lesions that are difficult to diagnose. The 23- and 35-gene expression profile (GEP) tests deliver results of suggestive of benign neoplasm, suggestive of malignant neoplasm, or intermediate (cannot exclude malignancy). They are intended to provide clinicians with objective results to be interpreted in the context of clinical, laboratory, and histopathological features to achieve a definitive diagnosis. Both GEPs are stand-alone tests that are independently validated and clinically available. Greater than 99% benign or malignant reporting is achieved clinically when the 23-GEP test is processed first, and if an intermediate result or test failure occurs, the 35-GEP is utilized.
Methods: The performance of the 23- and 35-GEP tests using this methodology was tested on unequivocal cases from a variety of subtypes (101 benign, 249 malignant). Lesions were included if 2/3 dermatopathologist diagnoses were concordant. Subtype designation was determined by the dermatopathologist that submitted the lesion for the study.
Results: The overall accuracy metrics in this cohort were 96.0% sensitivity and 87.8% specificity. The results demonstrated 100% sensitivity in several melanoma subtypes including acral lentiginous (n=15), desmoplastic (n=20), melanoma in situ (n=16), and nevoid (n=16). Other melanoma subtypes showed sensitivity metrics of: lentigo maligna, 96.7% (n=31); nodular, 95.1% (n=81); superficial spreading, 97.7% (n=42); and spitzoid, 85.0% (n=20). Subtypes of benign nevi showed a specificity of: blue, 96.7% (n=30); compound, 85.7% (n=42); junctional, 77.8% (n=18); and Spitz, 100% (n=7).
Conclusions: Overall, we demonstrate that use of the 23- and 35-GEP diagnostic test workflow results in high accuracy across many subtypes of benign and malignant melanocytic neoplasms.
Financial Disclosures: JAP has served as a consultant for Castle Biosciences, Inc. SIE is a consultant and shareholder of Castle Biosciences, Inc. BHR, JJS, JHR, JKW, SJK, and MSG are employee shareholders of Castle Biosciences, Inc. KM has served as a consultant and investigator for studies supported by Castle Biosciences, Inc. This study was supported by Castle Biosciences, Inc.
Association of TGFB3 and FGFs gene polymorphisms with cleft lip with or without cleft palate a systematic review
Authors: Quizhpi-Quito Andrea Soledad , Caparó Ebingen Villavicencio , Bravo-Calderón Diego Mauricio 
Published: May 2023

Objectives:
The objective of this study was to conduct a systematic review of the possible association between transforming growth factor B3 (TGFB3) and fibroblast growth factors (FGFs) gene polymorphisms and nonsyndromic cleft lip with or without cleft palate (NSCL/P).

Material and Methods:
Two reviewers independently screened studies by examining all titles and abstracts. Studies were included if they met the following criteria: The outcome of interest was NSCL/P; the polymorphisms studied were TGFB3 and FGF; they presented sufficient data, that is, allele/genotype frequency between cases and controls; or their odds ratio with 95% confidence interval. Study quality was independently assessed by a risk of bias assessment for genetic association studies.

Results:
Based on the inclusion criteria, we have selected a total of six articles (four for TGFB and two for FGF). Particularly for the TGFB gene, we have found significant results in exon 4 in the variant g.15812T>G, and in the single-nucleotide polymorphisms rs2300607 A/T, in the distribution between cases and controls. On the other hand, for the FGF gene, we observed a statistically significant in the genotype rs34010 CA.

Conclusion:
None of the genetic variations that show the association is verified in different populations; therefore, there is not enough scientific validation regarding the association between TGFB and FGF polymorphism and NSCL/P. The findings of the different studies suggest the need for further investigations with samples composed of a larger number of individuals in different populations, which should be performed with all the standards for genetic studies, thus allowing an understanding of the molecular basis of the disease.