bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sentence-level heuristic tree search for long text generation
Authors: Chen Zheng , Liu Zhejun 
Published: September 2023

AbstractIn this study, we primarily aim to address the exposure bias issue in long text generation intrinsic to statistical language models. We propose a sentence-level heuristic tree search algorithm, specially tailored for long text generation, to mitigate the problem by managing generated texts in a tree structure and curbing the compounding of biases. Our algorithm utilizes two pre-trained language models, an auto-regressive model for generating new sentences and an auto-encoder model for evaluating sentence quality. These models work in tandem to perform four critical operations: expanding the text tree with new sentences, evaluating the quality of the additions, sampling potential unfinished text fragments for further generation, and pruning leaf nodes deemed unpromising. This iterative process continues until a pre-defined number of [EOS] tokens are produced, at which point we select the highest-scoring completed text as our final output. Moreover, we pioneer two novel token-level decoding techniques—nucleus sampling with temperature and diverse beam search with sampling. These methods, integrated with our sentence-level search algorithm, aim to improve the consistency and diversity of text generation. Experimental results, both automated measures (including Jaccard similarity, Word2vec similarity, and unique word ratio) and human evaluations (assessing consistency, fluency, and rhetorical skills), conclusively demonstrate that our approach considerably enhances the quality of machine-generated long-form text. Through this research, we aim to inspire further innovations in sentence-level search-based text generation algorithms.
Catheter-related bloodstream infections in patients receiving hemodialysis in a single Philippine tertiary-care center
Authors: Mantaring Dan Meynard , Rollan Rohana Elise , Abad Cybele 
Published: September 2023

Background: Information regarding catheter-related bloodstream infections (CRBSIs) among patients on hemodialysis in the Philippines is lacking. Objective: In this study, we described the clinical profile, CRBSI incidence density, and outcomes of patients in a single-center hemodialysis unit. Methods: A retrospective review of patients receiving hemodialysis (HD) through a central venous catheter (CVC) from January 2016 to December 2020 in a tertiary-care, private hospital was performed. Baseline demographic data were recorded, and CRBSI incidence density rates (no. of CRBSIs per 1,000 catheter days) were calculated. Results: Of 868 hemodialysis patients (57%), 499 used a CVC and were followed for 182,135 catheter days. Half were male (248 of 499, 49.7%) with a median age of 62 years (range, 24–90). Only 48 (9.6%) of 499 developed CRBSI, with an overall CRBSI incidence of 2.63 per 1,000 catheter days. Of those with CRBSI, 31 (64.6%) of 48 were female. The median age was 74.5 years (range, 30–90). Hypertension (40 of 48, 83.3%) and diabetes mellitus (26 of 48, 54.2%) were frequent comorbidities. Fever with chills was the most common symptom, occurring in 30 (62.5%) of 48 patients. Both gram-positive (n = 24) and gram-negative (n = 25) organisms were isolated. Staphylococcus aureus was the most common gram-positive isolate (14 of 25, 56%); isolates from the order Enterobacterales (12 of 24, 50%) were the most common gram-negative organisms. More CRBSIs occurred among those with a nontunneled versus tunneled CVCs (28 vs 20). The median time to CRBSI occurrence was 7 weeks (range, 0.43–280) from CVC insertion. The most common empiric treatment was either vancomycin (n = 28) or piperacillin-tazobactam (n = 26), which were also used in combination (11 of 28, 39.3%). Treatment involved CVC removal in most patients (34 of 48, 70.8%), either alone (n = 1), or with systemic antibiotic therapy (SAT; n = 16), or SAT plus antibiotic lock therapy (ALT; n = 17). The remainder (14 of 48, 29.2%) retained their CVCs because of difficult access, and received both SAT and ALT. Attributable mortality (6 of 9, 33%) and overall mortality (9 of 48, 18.5%) were high. Mortality of those whose CVC was retained was lower compared to those whose line was removed: (3 of 9, 33%) versus (6 of 9, 66%). Conclusions: The overall CRBSI rate in our hemodialysis unit was low and occurred more commonly in the older age group with a nontunneled CVC. Both gram-positive and gram-negative pathogens were common. CRBSI was associated with high attributable mortality. Successful treatment often required CVC, SAT, and ALT. However, CVC retention was a viable option in some patients with specific limiting factors such as difficult access.Disclosures: None
3D printers in hospitals: Reducing bacterial contamination on 3D-printed material
Authors: Jackson Katelin , Call Douglas , Lofgren Eric 
Published: September 2023

Background: COVID-19 has presented hospitals with unique challenges. An SHEA Research Network survey showed that 40% reported “limited” or worse levels of personal protective equipment (PPE) and that 13% were self-producing PPE to address those deficits, including 3D-printed items. However, we do not know how efficiently, if at all, 3D-printed materials can be disinfected. Additionally, 2 filaments, PLACTIVE and PUREMENT, claim to be antimicrobial; they use copper nanocomposites and silver ions to reduce bacterial populations. We assessed how PLACTIVE and PUREMENT may be contaminated and how well they reduce contamination, and how readily polylactic acid (PLA), a standard 3D-printed material, may be disinfected. Methods: We grew methicillin-resistant and -susceptible Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae on 3D-printed disks and conducted bacterial survival assays to determine whether bacteria grow on PLA, PLACTIVE, and PUREMENT. We performed a time series (with 3- and 24-hour dry times) followed by serial dilutions to attain colony-forming unit (CFU) averages for each strain per disk. To determine whether 3D-printed material can be cleaned, we used 70% EtOH on PLA only. We conducted the same time series followed by a disinfectant time series (with dry times 30 seconds, 2.5, minutes, 5 minutes, and 10 minutes). Again, serial dilutions were performed to attain the PLA CFU averages with disinfectant. The CFU averages from the control group (PLA) and testing group (PLACTIVE and PUREMENT) were compared to see how well the antimicrobial material decreased bacterial load. We also compared the CFU averages of PLA with and without disinfectant to see how well 70% EtOH decreased bacterial load. Results: 3D-printed material is readily contaminated with bacteria common in hospitals and can sustain that contamination. Antimicrobial materials, PLACTIVE and PUREMENT, had lower levels of bacterial contamination when compared to PLA. However, disinfected disks had lower overall CFU averages than those that were not, but the level of disinfection was variable and bacterial populations recovered hours after disinfection application. Conclusions: Proper disinfection and using appropriate 3D-printed materials are essential to limiting bacterial contamination. 3D printers and their products can be invaluable for hospitals, especially when supplies are low and healthcare worker safety is paramount. Environmental services should be made aware of the presence of antimicrobial 3D-printed materials, and patients should be discouraged from printing their own items for use in hospital environments.Disclosures: None
The Evolve to Next-Gen ACT Network: An evolving open-access, real-world data resource primed for real-world evidence research across the Clinical and Translational Science Award Consortium
Authors: Morrato Elaine H. , Lennox Lindsay A. , Dearing James W. , Coughlan Anne T. , Gano Elaina S. , McFadden Doug , Mora Nallely , Pincus Harold Alan , Firestein Gary S. , Toto Robert , Reis Steven E. 
Published: September 2023

Abstract
The ACT Network was funded by NIH to provide investigators from across the Clinical and Translational Science Award (CTSA) Consortium the ability to directly query national federated electronic health record (EHR) data for cohort discovery and feasibility assessment of multi-site studies. NIH refunded the program for expanded research application to become “Evolve to Next-Gen ACT” (ENACT). In parallel, the US Food and Drug Administration has been evaluating the use of real-world data (RWD), including EHR data, as sources of real-world evidence (RWE) for its regulatory decisions involving drug and biological products. Using insights from implementation science, six lessons learned from ACT for developing and sustaining RWD/RWE infrastructures and networks across the CTSA Consortium are presented in order to inform ENACT’s development from the outset. Lessons include intentional institutional relationship management, end-user engagement, beta-testing, and customer-driven adaptation. The ENACT team is also conducting customer discovery interviews with CTSA hub and investigators using Innovation-Corps@NCATS (I-Corps™) methodology for biomedical entrepreneurs to uncover unmet RWD needs. Possible ENACT value proposition hypotheses are presented by stage of research. Developing evidence about methods for sustaining academically derived data infrastructures and support can advance the science of translation and support our nation’s RWD/RWE research capacity.
Medical Assistance in the De-Occupied Ukrainian Territory
Authors: Mazurenko Oleg V. , Roshchin Georgiy G. , Slychko Ivan Yo 
Published: September 2023

AbstractIntroduction:The Russian invasion of Ukraine in 2022 has affected more people and destroyed a local public health facility. When some territories in Ukraine were de-occupied, national and international mobile clinics (MCs) were involved for medical assistance to local inhabitants. Knowledge about population health, medical, and humanitarian needs after they have been de-occupied has to improve planning for health system response.Objective:The aim of this study was to summarized the MC experience at the first month after the area was de-occupied, as well as to show out-patient visits and to identify a need for medicines and medical equipment in the MC.Methods:The information related to the missions was obtained by direct observation and estimation on empirical data gathering in the field during a twelve-day mission in April-May 2022. All patients were divided by age, sex, and diseases according to the International Classification of Diseases-10 (ICD-10). During the twelve-day MC mission, medical assistance was provided for 478 out-patients. Descriptive statistical methods were undertaken using Microsoft Office 2019, Excel with data analysis.Interventions:All out-patients were evaluated clinically. Personal medical cards were completed for each patient. Glucose testing as well as tests for coronavirus disease 2019/COVID-19 had been done, if it was necessary. All sick persons were treated for their disease.Results:The priority needs for emergency and primary medical care, medicines, and hygienic and sanitation supplies after the area was de-occupied were fixed. The most frequent reasons for visiting the МС were: hypertension (27.6%), musculoskeletal-related (arthritis) diseases (26.9%), heart and peripheral vascular diseases (12.1%), upper gastrointestinal disorder (5.4%), upper respiratory infection (5.0%), and diabetes Type-2 (3.7%). Other diagnoses such as lower respiratory tract infection, diagnoses of the digestive system (hemorrhoids and perianal venous thrombosis), chronic obstructive pulmonary disease/COPD or asthma, eye diseases, gynecology-related condition, menstrual condition, and urinary tract disorder were distributed almost equally (0.21%-2.51%) among the patient population.Conclusions:In the de-occupied territories, a health responder could be ready for medical assistance to patients with noncommunicable diseases (NCDs) as well as to support a person with psychological reactions who asked for sedatives and sleep-inducing medicines. These data clearly demonstrate that MCs must be equipped by blood pressure (BP) monitor, stethoscope, pulse oximeter, and diabetes testing kit glucose with essential medicines. This study improves health response planning for local civilian populations in de-occupied territory.
Household food insecurity in South Africa from 1999 to 2021: a metrics perspective
Authors: van den Berg Louise , Walsh Corinna May 
Published: September 2023

AbstractObjective:To review and synthesize studies on household food security in South Africa.Design:Systematic mapping review of metrics (methodological review).Setting:Electronic databases, including EBSCOHost, Scopus and Web of Science, were searched for studies and reports on household food security in South Africa, reporting household food security published between 1999 and 2021. Searching, selecting and reporting were performed according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement.Participants:South African householdsResults:Forty-eight articles reporting on six national surveys (one repeated annually since 2002) and forty sub-national studies meeting the inclusion criteria were selected. Various metrics, with different recall periods and ways of categorizing food security levels, were identified. Surveys that used similar metrics showed that the percentage of South African households that have experienced food insecurity and hunger has decreased over the review period yet remains concerning. However, the multitude of metrics used to assess the different components and levels of food security limits the comparability of the results to evaluate the scope and scale of the problem.Conclusions:There is growing support for developing multi-variable approaches for food security research in sub-Saharan Africa. Future research should focus on finding the most appropriate combination of complementary metrics that would allow comparable data while holistically capturing food security and providing insight into the causes and consequences.
Plio‐Pleistocene Southwest African Hydroclimate Modulated by Benguela and Indian Ocean Temperatures
Authors: Rubbelke Claire B. , Bhattacharya Tripti , Feng Ran , Burls Natalie J. , Knapp Scott , McClymont Erin L. 
Published: September 2023

AbstractFuture projections of southwestern African hydroclimate are highly uncertain. However, insights from past warm climates, like the Pliocene, can reveal mechanisms of future change and help benchmark models. Using leaf wax hydrogen isotopes to reconstruct precipitation (δDp) from Namibia over the past 5 million years, we find a long‐term depletion trend (−50‰). Empirical mode decomposition indicates this trend is linked to sea surface temperatures (SSTs) within the Benguela Upwelling System, but modulated by Indian Ocean SSTs on shorter timescales. The influence of SSTs on reconstructed regional hydroclimate is similar to that observed during modern Benguela Nio events, which bring extreme flooding to the region. Isotope‐enabled simulations and PlioMIP2 results suggest that capturing a Benguela Nio‐like state is key to accurately simulating Pliocene, and future, regional hydroclimate. This has implications for future regional climate, since an increased frequency of Benguela Nios poses risk to the ecosystems and industries in the region.
Receiver Function Adjoint Tomography for Three‐Dimensional High‐Resolution Seismic Array Imaging: Methodology and Applications in Southeastern Tibet
Authors: Xu Mijian , Wang Kai , Chen Jing , Yu Dayong , Tong Ping 
Published: September 2023

AbstractA new technique for P‐wave receiver function (PRF) inversion, within the framework of wave equation‐based adjoint tomography and referred to as receiver function adjoint tomography (RFAT), has been developed to obtain models of Vp, Vs, and density. This innovative technique fits the synthetic PRFs with observed PRFs and can better image the lateral variations of Vs from the crust to the uppermost mantle than traditional 1‐D PRF inversion. We utilized RFAT to perform high‐resolution imaging beneath a dense seismic array in Southeastern Tibet, revealing low‐velocity zones extending from the uppermost mantle to the crust, as well as an eastward dipping Moho under the Red River Fault (RRF). Our inversion results provide direct evidence for the existence of a distinct asthenospheric upwelling channel beneath the RRF, and further highlight the effectiveness of RFAT for accurately imaging subsurface structures.
Deep Learning Improves Reconstruction of Ocean Vertical Velocity
Authors: Zhu Ruichen , Li Yanqin , Chen Zhaohui , Du Tianshi , Zhang Yueqi , Li Zhuoran , Jing Zhiyou , Yang Haiyuan , Jing Zhao , Wu Lixin 
Published: September 2023

AbstractOcean vertical velocity (w) plays a key role in regulating the exchanges of mass, heat and nutrients between the surface and deep ocean. However, direct observation remains difficult due to its small magnitude and large spatiotemporal variability. Therefore, w fields are generally diagnosed using dynamic‐based methods. In this study, we developed a deep neural network (DNN) to reconstruct three‐dimensional fields of ocean vertical velocity based on sea surface height (SSH) fields. Compared to dynamic‐based methods, the DNN shows improved performance in the w reconstruction within upper 500 m in terms of higher correlation and less error. Remarkably, the DNN requires only a ∼45 × 45 km size SSH image as input to estimate w at the center. This suggests that the DNN has great potential for w reconstruction in the future combined with high‐resolution observations such as the Surface Water and Ocean Topography mission.
Majorana zero modes in Y-shape interacting Kitaev wires
Authors: Pandey Bradraj , Kaushal Nitin , Alvarez Gonzalo , Dagotto Elbio 
Published: September 2023

AbstractMotivated by the recent experimental realization of minimal Kitaev chains using quantum dots, we investigate the Majorana zero modes (MZM) in Y-shape Kitaev wires. We solve the associated Kitaev models analytically at the sweet spot (th = Δ) and derive the exact form of MZM wave-functions in this geometry. We observed exotic multi-site MZMs located near the junction center, on the nearby edge sites of each leg. This result is important for potential braiding of Majoranas and the performance of Y-junctions made from arrays of quantum dots. Furthermore, we study the stability of local (single-site) and multi-site MZMs modes in the presence of Coulomb repulsion, using density matrix renormalization group theory. Our local density-of-states calculation shows that these multi-site MZMs are as equally topologically protected as the single-site MZMs when in the presence of Coulomb repulsion or when away from the sweet-spot.
An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration
Authors: Romero-Torrecilla Juan Antonio , Lamo-Espinosa José María , Ripalda-Cemboráin Purificación , López-Martínez Tania , Abizanda Gloria , Riera-Álvarez Luis , de Galarreta-Moriones Sergio Ruiz , López-Barberena Asier , Rodríguez-Flórez Naiara , Elizalde Reyes , Jayawarna Vineetha , Valdés-Fernández José , de Anleo Miguel Echanove-González , Childs Peter , de Juan-Pardo Elena , Salmeron-Sanchez Manuel , Prósper Felipe , Muiños-López Emma , Granero-Moltó Froilán 
Published: September 2023

AbstractDuring bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth factors to the injured bone. We developed a biocompatible, 3D polycaprolactone (PCL) melt electro-written membrane to act as a mimetic periosteum. Poly (ethyl acrylate) coating of the PCL membrane allowed functionalization, mediated by fibronectin and low dose recombinant human BMP-2 (rhBMP-2) (10-25 μg/ml), resulting in efficient, sustained osteoinduction in vitro. In vivo, rhBMP-2 functionalized mimetic periosteum demonstrated regenerative potential in the treatment of rat critical-size femoral defects with highly efficient healing and functional recovery (80%-93%). Mimetic periosteum has also proven to be efficient for cell delivery, as observed through the migration of transplanted periosteum-derived mesenchymal cells to the bone defect and their survival. Ultimately, mimetic periosteum demonstrated its ability to deliver key stem cells and morphogens to an injured site, exposing a therapeutic and translational potential in vivo when combined with unprecedentedly low rhBMP-2 doses.
Finding normal-to-better neurocognitive indexes in individuals with schizotypal traits using a social role task
Authors: Diao Mingyi , Demchenko Ilya , Asare Gifty , Quan Jingyan , Debruille J. Bruno 
Published: September 2023

AbstractSchizophrenia patients make more errors and have longer reaction times (RTs) than healthy controls in most cognitive tasks. Deficits are also observed in subclinical participants having high scores on the schizotypal personality questionnaire (SPQ). They are accompanied by smaller amplitudes of the event-related brain potentials (ERPs) that index attention and semantic- and working-memory. These functions are thus thought to be impaired in individuals having various schizophrenia attributes (SzAs). Nevertheless, normal RTs were recently found in SzAs during a particular self-referential task where half of the stimuli were names of extraordinary social roles (e.g., genius). Each name (ordinary or extraordinary) was presented individually, and participants were asked to decide whether or not they would consider themselves performing the role at any moment of their lives. To further test an absence of cognitive deficits in this task, the ERPs elicited by names of social roles were also examined in 175 healthy participants. The absence of longer RTs in high- than in low-SPQs was replicated. Moreover, the ERPs of high SPQs had larger occipital N1s, larger P2s and larger occipital N400s than those of low SPQs while late positive potentials (LPPs) were of similar amplitudes. Such results are consistent with clinical observations of greater attention and faster processing of stimuli related to extraordinary/delusional beliefs. Further studies should test whether the cognitive deficits found in SzAs are due to the use of tasks and stimuli that are less within their focus of interest than within that of healthy controls.
Shared metabolic shifts in endothelial cells in stroke and Alzheimer’s disease revealed by integrated analysis
Authors: Guo Guangyu , Fan Liyuan , Yan Yingxue , Xu Yunhao , Deng Zhifen , Tian Miaomiao , Geng Yaoqi , Xia Zongping , Xu Yuming 
Published: September 2023

AbstractSince metabolic dysregulation is a hallmark of both stroke and Alzheimer’s disease (AD), mining shared metabolic patterns in these diseases will help to identify their possible pathogenic mechanisms and potential intervention targets. However, a systematic integration analysis of the metabolic networks of the these diseases is still lacking. In this study, we integrated single-cell RNA sequencing datasets of ischemic stroke (IS), hemorrhagic stroke (HS) and AD models to construct metabolic flux profiles at the single-cell level. We discovered that the three disorders cause shared metabolic shifts in endothelial cells. These altered metabolic modules were mainly enriched in the transporter-related pathways and were predicted to potentially lead to a decrease in metabolites such as pyruvate and fumarate. We further found that Lef1, Elk3 and Fosl1 may be upstream transcriptional regulators causing metabolic shifts and may be possible targets for interventions that halt the course of neurodegeneration.