bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chatbot-Delivered Online Intervention to Promote Seasonal Influenza Vaccination During the COVID-19 Pandemic
Authors: Wang Zixin , Chan Paul Shing-fong , Fang Yuan , Yu Fuk-yuen , Ye Danhua , Zhang Qingpeng , Wong Martin C. S. , Mo Phoenix K. H. 
Published: September 2023

ImportanceReceiving seasonal influenza vaccination (SIV) is important for adults during the COVID-19 pandemic. There are few robust evaluations of tailored interventions for improving SIV uptake among adults 65 years or older.ObjectiveTo evaluate the relative efficacy of a stages of change (SOC)-tailored online intervention compared with a standard, non–SOC-tailored online intervention in increasing SIV uptake among Hong Kong residents 65 years or older.Design, Setting, and ParticipantsThis nonblinded parallel-group randomized clinical trial was conducted between December 1, 2021, and July 31, 2022, in Hong Kong, China. Eligible participants were 65 years or older, had Cantonese- and/or Mandarin-speaking skills, were community-dwelling, had Hong Kong residency, were smartphone users, and had not received SIV for the 2021 to 2022 influenza season. Participants were recruited through random telephone calls, and those who completed the baseline telephone survey were randomized to either the intervention or control group. Both complete case and intention-to-treat (ITT) analyses were performed.InterventionIn the intervention group, a simplified rule-based chatbot first assessed participants’ SOC related to SIV uptake and then automatically selected and sent participants SOC-tailored online health promotion messages (videos) through a messaging application (WhatsApp; Meta) once every 2 weeks for 4 sessions. In the control group, the chatbot sent a link to access through the messaging application a standard online health promotion message (video) covering general SIV information every 2 weeks for 4 sessions.Main Outcomes and MeasuresThe primary outcome was self-reported SIV uptake at month 6, which was validated by the research team. The secondary outcome was SOC measured at both baseline and month 6 by validated questions.ResultsA total of 396 participants (mean [SD] age of 70.2 [4.3] years; 249 females [62.9%]) were randomized to the intervention (n = 198) or control (n = 198) group. The ITT analysis showed that the validated SIV uptake rate was higher in the intervention group than the control group at month 6 (50.5% vs 35.3%; P = .002). The mean (SD) SOC score was higher in the intervention group than the control group (2.8 [1.4] vs 2.4 [1.4]; P = .02). More participants in the intervention group completed at least 1 episode of intervention than in the control group (77.3% vs 62.6%; P &amp;lt; .001).ConclusionsResults of this trial indicate that the SOC-tailored online intervention was more effective than the non–SOC-tailored intervention and may be a sustainable new method in increasing SIV uptake among adults 65 years or older.Trial RegistrationClinicalTrials.gov Identifier: NCT05155241
A study on how regional management organizations operate and utilize social educational facilities as their base facilities, community development by residents through small‐scale multifunctional self‐government
Authors: Deguchi Toshihisa , Kohriya Hisahide , Fukuda Nana , Taniguchi Naohiro 
Published: September 2023

AbstractThe establishment of kominkan, a public institution for social education in Japan, was proposed by the Ministry of Education, Science, Sports and Culture (currently called the Ministry of Education, Culture, Sports, Science and Technology) in 1946. Since then, the establishment of kominkan has progressed rapidly throughout Japan. In the meantime, regional autonomy should be broadened to regional management autonomy. Since 2014, the government has promoted the establishment of regional management organizations (RMOs) that implement projects with business perspectives and approaches. According to a survey conducted by the Ministry of Internal Affairs and Communications (MIC), kominkan play a significant role in the establishment of RMOs. In this research, we investigated and quantitatively analyzed (1) the status of RMOs across Japan for which kominkan, etc., are involved in their establishment and operation and (2) some pioneering examples. In our quantitative analysis, a questionnaire survey was conducted among the RMOs in 255 municipalities to understand the status of the base facilities in the establishment of RMOs and to clarify the relationship of the RMOs with kominkan. In our qualitative analysis, on‐site or online hearing surveys were conducted among the RMOs in eight municipalities where many activities were carried out, according to the results of our quantitative analysis. The results of those surveys showed that local governments took the lead in establishing RMOs in many cases and that the largest number of activities was carried out at the initiative of local governments at the community centers that are former kominkan. The survey results also revealed that kominkan and the community centers that are former kominkan contribute significantly to the establishment of RMOs. Considering that the main players in community development are residents, the support from local governments to RMOs should be examined and designed to encourage the independence of residents. Social education administration may play a proactive role in achieving this goal. It is said that community development is human development. RMOs should therefore focus on human resources development as their key mission. This is why we believe that the establishment of RMOs based on kominkan activities will lead to resident‐led community development.
Propensity matched comparison of omaveloxolone treatment to Friedreich ataxia natural history data
Authors: Lynch David R. , Goldsberry Angie , Rummey Christian , Farmer Jennifer , Boesch Sylvia , Delatycki Martin B. , Giunti Paola , Hoyle J. Chad , Mariotti Caterina , Mathews Katherine D. , Nachbauer Wolfgang , Perlman Susan , Subramony S.H. , Wilmot George , Zesiewicz Theresa , Weissfeld Lisa , Meyer Colin 
Published: September 2023

AbstractObjectiveThe natural history of Friedreich ataxia is being investigated in a multi‐center longitudinal study designated the Friedreich ataxia Clinical Outcome Measures Study (FACOMS). To understand the utility of this study in analysis of clinical trials, we performed a propensity‐matched comparison of data from the open‐label MOXIe extension (omaveloxolone) to that from FACOMS.MethodsMOXIe extension patients were matched to FACOMS patients using logistic regression to estimate propensity scores based on multiple covariates: sex, baseline age, age of onset, baseline modified Friedreich Ataxia Rating scale (mFARS) score, and baseline gait score. The change from baseline in mFARS at Year 3 for the MOXIe extension patients compared to the matched FACOMS patients was analyzed as the primary efficacy endpoint using mixed model repeated measures analysis.ResultsData from the MOXIe extension show that omaveloxolone provided persistent benefit over 3 years when compared to an untreated, matched cohort from FACOMS. At each year, in all analysis populations, patients in the MOXIe extension experienced a smaller change from baseline in mFARS score than matched FACOMS patients. In the primary pooled population (136 patients in each group) by Year 3, patients in the FACOMS matched set progressed 6.6 points whereas patients treated with omaveloxolone in MOXIe extension progressed 3 points (difference = −3.6; nominal p value = 0.0001).InterpretationThese results suggest a meaningful slowing of Friedreich ataxia progression with omaveloxolone, and consequently detail how propensity‐matched analysis may contribute to understanding of effects of therapeutic agents. This demonstrates the direct value of natural history studies in clinical trial evaluations.
Antimalarial Adherence and Risk of Cardiovascular Events in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus: A Population‐Based Study
Authors: Hoque Md Rashedul , Aviña‐Zubieta J Antonio , Lacaille Diane , De Vera Mary A. , Qian Yi , McCandless Lawrence , Esdaile John M. , Xie Hui 
Published: September 2023

ObjectiveWe aimed to assess the association between antimalarial adherence and cardiovascular events between incident rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) population‐based cohorts.MethodsAll patients with incident RA/SLE and incident antimalarial use in British Columbia, Canada, between January 1997 and March 2015 were identified using provincial administrative databases. The outcomes were incident cardiovascular events, including myocardial infarction (MI), stroke, or venous thromboembolism (VTE). The exposure was antimalarial adherence with levels: discontinuation (proportion of days covered [PDC = 0]), nonadherence (0 < PDC < 0.90), and adherence (PDC ≥ 0.90). We used marginal structural models to estimate the effect of antimalarial adherence on the rate of cardiovascular events, accounting for potential confounders.ResultsWe identified 16,538 individuals with incident RA/SLE and incident antimalarial use without any cardiovascular event before the index date. Over nine years mean follow‐up, 2,174 incident cardiovascular events (13.2%) were observed. The adjusted hazard ratio (aHR) for incident cardiovascular events for antimalarial adherence relative to discontinuation was 0.72 (95% confidence interval [CI] 0.64–0.81) and 1.01 (95% CI 0.90–1.14) for nonadherence. Additionally, the aHRs for all cardiovascular events, MI, stroke, and VTE for adherence relative to nonadherence was 0.71 (95% CI 0.61–0.82), 0.62 (95% CI 0.51–0.75), 0.45 (95% CI 0.36–0.58), and 0.65 (95% CI 0.46–0.93), respectively. We found older age modified the association between antimalarial adherence and cardiovascular events (P = 0.02).ConclusionWhen people newly diagnosed with RA or SLE take their antimalarial regularly as prescribed (PDC ≥ 0.90), they have a 29% lower risk of sustaining a cardiovascular event than patients with a lower degree of adherence (PDC < 0.90) and a 28% lower risk than if they discontinue antimalarials.
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Aromatic Donor–Acceptor Charge‐Transfer Interactions Reinforced Supramolecular Polymer Electrolyte for Solid‐State Lithium Batteries
Authors: Yan Shuaishuai , Wang Zhan , Liu Fengxiang , Zhou Hangyu , Liu Kai 
Published: September 2023

AbstractPolymer electrolytes have great potential to realize solid‐state lithium metal batteries with high energy density and intrinsic safety. However, the poor mechanical strength and uncontrolled electrolyte/electrode interface cannot guarantee the stable operation during long‐term cycling. Herein, a supramolecular polyurethane material reinforced by aromatic charge‐transfer interactions is synthesized as electrolyte matrix with high stiffness, excellent toughness, and unique mechanical energy dissipation capacity. The optimized electrolyte network can dynamically adapt to the volume fluctuating Li metal and, importantly, eliminate stress‐concentrating behavior under deformed state. As a result, the Li/Li symmetric cells can stably work for more than 3500 h without short circuit. And the LiFePO4/Li batteries show superior electrochemical performance over 1200 cycles with a capacity retention of 95.4% at 0.33 C. The supramolecular approach to tune the mechanical properties of the polymers is believed to provide a new strategy for designing solid electrolytes with desirable comprehensive mechanical properties for solid‐state batteries.
Weak Interaction Between Cations and Anions in Electrolyte Enabling Fast Dual‐Ion Storage for Potassium‐Ion Hybrid Capacitors
Authors: Zhang Chenglin , Yan Chengzhan , Jin Rui , Hao Jinhui , Xing Zihao , Zhang Peng , Wu Yuhan , Li Longhua , Zhao Huaping , Wang Shun , Shi Weidong , Lei Yong 
Published: September 2023

AbstractIdentifying an effective electrolyte is a primary challenge for hybrid ion capacitors, due to the intricacy of dual‐ion storage. Here, this study demonstrates that the electrochemical behavior of graphite oxide in ether‐solvent electrolyte outperforms those in ester‐solvent electrolytes for the cathode of potassium‐ion hybrid capacitor. The experimental and theoretical assessments verify that the anion and cation are isolated effectively in dimethyl ether, endowing a weaker interaction between cations and anions compared to that of ester‐solvent electrolytes, which facilitates the dual‐ion diffusion and thus enhances the electrochemical performance. This result provides a rational strategy to realize high‐rate cations and anions storage on the carbon cathode. Furthermore, a new low‐cost and high‐performance capacitor prototype, modified graphite oxide (MGO) cathode versus pristine graphite (PG) in ether‐solvent electrolyte (MGOǁDMEǁPG), is proposed. It exhibits a high energy density of 150 Wh kg−1cathode at a high power density of 21443 W kg−1cathode (calculation based on total mass: 60 Wh kg−1 at 8577 W kg−1).
Multilevel Encoding Physically Unclonable Functions Based on The Multispecies Structure in Diamonds
Authors: Guo Hao , Qin Yue , Wang Zhibin , Ma Yuxing , Wen Huanfei , Li Zhonghao , Ma Zongmin , Li Xin , Tang Jun , Liu Jun 
Published: September 2023

AbstractThe multilevel encoding (MLE) scheme is an effective method for improving the anticounterfeiting encryption capabilities of physically unclonable functions (PUFs). However, owing to the correlation between encoding layers, the encoding capacity (EC) is difficult to improve by orders of magnitude. Herein, four noncorrelated structures in the diamond crystal structure (carbon–carbon single bond, defect luminescence structures, spin structures, and electron energy distribution structures) are considered for MLE. First, the microdiamonds containing nitrogen‐vacancy (NV) color centers are embedded into polydimethylsiloxane (PDMS) to fabricate PUFs. Using an optical imaging system, four codable images of four noncorrelated structures are read. The noncorrelation of the four‐level encoding structure is verified by calculating the Hamming distance (0.496 ± 0.02). The results show that EC exponentially improves to 24×10 000/(100 pixels)2. Furthermore, the encoding method based on the energy level does not depend on physical structure parameters, such as the size and position of the spin structure. Thus, it is protected from structural modeling attacks, resulting in high security. Moreover, PUF labels based on PDMS flexible substrates can be employed for various flexible applications. In the proposed scheme, the information is encrypted by a four‐level two‐dimensional (2D) barcode and decoded by self‐developed PUF authentication software. The proposed scheme presents a way for developing next‐generation PUFs with super‐high EC.
3D Adsorption‐Mediator Network Polymer Binders Improve Redox Kinetics and Flame Retardant Performance for High Loading Lithium–Sulfur Batteries
Authors: Li Borui , Zhang Tianpeng , Song Zihui , Jiang Wanyuan , Yang Jiangpu , Pei Mengfan , Mao Runyue , Jian Xigao , Hu Fangyuan 
Published: September 2023

AbstractThe commercial application of lithium–sulfur (Li–S) batteries is severely impeded by abominable shuttle effects, sluggish redox kinetics, and poor safety performance under high loading conditions. Herein, a novel adsorption‐mediator synergistic polymer binder (PAT) is reported to regulate the conversion of lithium polysulfides (LiPSs) through close intermolecular synergy. The abundant polar groups provide strong anchor ability for LiPSs to effectively inhibit the shuttle effect, and the anchored LiPSs are accelerated by adjacent mediator catalytic sites to facilitate their redox kinetics. Moreover, PAT itself features excellent flame retardant properties, which effectively enhance the safety performance of Li–S cells. Benefiting from these attributes, PAT‐based Li–S cells exhibit outstanding rate performance with an average capacity of 617.34 mAh g−1 at 5 C and excellent cycling stability maintaining a capacity of 629.1 mAh g−1 after 800 cycles at 2 C. Even under the harsh conditions of high loading (9.84 mg cm−2) and lean electrolyte (E/S = 3.56 µL mg−1), PAT‐based cell delivers a high average areal capacity of 9.58 mAh cm−2 and an ultralow overpotential of 3 mV, confirming the application potential of adsorption‐mediator synergistic polymer binder in high performance Li–S batteries.
3D Plasmonic Gold Nanopocket Structure for SERS Machine Learning‐Based Microplastic Detection
Authors: Kim Jun Young , Koh Eun Hye , Yang Jun‐Yeong , Mun Chaewon , Lee Seunghun , Lee Hyoyoung , Kim Jaewoo , Park Sung‐Gyu , Kang Mijeong , Kim Dong‐Ho , Jung Ho Sang 
Published: September 2023

AbstractMicroplastics (MPs) are present not only in the environment but also in drinking water, food, and consumer products. These MPs being toxic, carcinogenic, endocrine disrupting, and genetic risk creators cause several diseases. Despite various approaches, the development of onsite applicable, facile, and quick MP detection methods is still challenging. Here, 3D‐plasmonic gold nanopocket (3D‐PGNP) nanoarchitecture is formed on a paper substrate for simultaneous MP filtration and detection. The paper‐based 3D‐PGNP is integrated with a syringe filter device, and then, MP‐containing solutions are injected through the syringe. Subsequent detection of the MPs using the surface‐enhanced Raman scattering (SERS) successfully identifies the MPs without pretreatment. The interface and volumetric hotspot generation of 3D‐PGNP around the captured MPs significantly improves the sensitivity, which is confirmed by finite‐difference time‐domain simulation. Then, the SERS mapping images obtained from a portable Raman spectrometer are transformed into digital signals via machine learning (ML) technique to identify and quantify the MP distribution. The developed SERS‐ML‐based MP detection method is applied for mixture MPs and for real matrix samples, demonstrating that the method provides improved accuracy. This system is expected to be used for various MPs detection and for environmentally hazardous substances, such as bacteria, viruses, and fungi.
Self‐Emulsifying Drug Delivery Systems (SEDDS) Containing Reverse Micelles: Advanced Oral Formulations for Therapeutic Peptides
Authors: Jörgensen Arne Matteo , Steinbring Christian , Stengel Daniel , To Dennis , Schmid Pascal , Bernkop‐Schnürch Andreas 
Published: September 2023

AbstractAlternative methods to hydrophobic ion pairing for the formation of lipophilic complexes of peptide drugs to incorporate them in lipid‐based nanocarriers such as self‐emulsifying drug delivery systems (SEDDS) for oral administration are highly on demand. Such an alternative might be reverse micelles. Within this study, SEDDS containing dry reverse micelles (dRMsPMB) formed with an anionic (sodium docusate; AOT), cationic (dimethyl‐dioctadecyl‐ammonium bromide; DODAB), amphoteric (soy lecithin; SL), or non‐ionic (polysorbate 85; P85) surfactant loaded with the model peptide drug polymyxin B (PMB) are developed. They are characterized regarding size, payload, release kinetics, cellular uptake, and peptide activity.SEDDS exhibit sizes from 22.2 ± 1.7 (AOT‐SEDDS‐dRMsPMB) to 61.7 ± 3.2 nm (P85‐SEDDS‐dRMsPMB) with payloads up to 2% that are approximately sevenfold higher than those obtained via hydrophobic ion pairing. Within 6 h P85‐SEDDS‐dRMsPMB and AOT‐SEDDS‐dRMsPMB show no release of PMB in aqueous medium, whereas DODAB‐SEDDS‐dRMsPMB and SL‐SEDDS‐dRMsPMB show a sustained release. DODAB‐SEDDS‐dRMsPMB improves uptake by Caco‐2 cells most efficiently reaching even ≈100% within 4 h followed by AOT‐SEDDS‐dRMsPMB with ≈20% and P85‐/SL‐SEDDS‐dRMsPMB with ≈5%. The peptide drug maintains its antimicrobial activity in all SEDDS‐dRMsPMB.According to these results, SEDDS containing dRMs might be a game changing strategy for oral peptide drug delivery.
Bioactivable STING Nanoagonists to Synergize NIR‐II Mild Photothermal Therapy Primed Robust and Long‐Term Anticancer Immunity
Authors: Ma Wen , Sun Rui , Tang Longguang , Li Zibo , Lin Ling , Mai Ziyi , Chen Gui , Yu Zhiqiang 
Published: September 2023

AbstractPharmacological activation of the stimulator of interferon genes (STING) pathway has become a promising strategy for cancer immunotherapy. However, the insufficient tumorous accumulation, rapid clearance, and short duration of drug efficacy in the tumor microenvironment of small structural STING agonists greatly compromise the therapeutic efficacy. Herein, a tumorous extracellular matrix (ECM) is presented anchoring STING agonist‐based photoimmunothernostic nanomedicine (SAPTN) that can be activated by mild‐temperature photothermal therapy (mild PTT) induced neutrophilic inflammation. The SAPTN owns second window near‐infrared (NIR‐II) photonics properties fitting for NIR‐II fluorescence and photoacoustic imaging‐guided cancer therapy. The aggregates SAPTN targeting to the ECM provide slow and continuous release of potent STING agonists diABZIs. The mild PTT and long‐lasting STING agonists released in the ECM synergistically prime systematic, robust, and long‐term anticancer immunity. In a tumor model, this approach leads to complete tumor eradication in about 100% of mice with orthotopic breast tumors, and the mice regained tumor‐free survival of at least 2 months. In addition, the immune‐mediated abscopal effect shows inhibition of the distant solid tumor growth by intratumoral administration of SAPTN with laser irradiation. Overall, this approach represents a generalized photoactivable nanomedicine to prime anticancer immunity for improved cancer theranostics.
A Programmable Oxygenation Device Facilitates Oxygen Generation and Replenishment to Promote Wound Healing
Authors: Yang Jumin , Jin Xin , Liu Wenguang , Wang Wei 
Published: September 2023

AbstractInadequate oxygenation is one of the chief culprits for delayed wound healing. However, current oxygen therapies, such as hyperbaric oxygen therapy and topical oxygen therapy, face hurdles in providing sustained and long‐term oxygenation to reverse wound hypoxia. Furthermore, their efficacy in rejuvenating wound injury is restricted by limited penetration of oxygen in the wound bed. Herein, this study proposes a programmable and portable oxygenation device (named GUFO oxydevice) by ingeniously integrating i) a controllable oxygen generation and unidirectional transmission system (COGT‐UTS), and ii) a supramolecular assembled perfluorinated hyperbranched polymer/gelatin (GUF) hydrogel in which the perfluorinated hyperbranched polymer (FHBP) acts as an oxygen reservoir to ensure sustained and convenient oxygen replenishment and thus directly regulate the hypoxic wound microenvironment. Accelerating the wound healing process by GUFO oxydevice is achieved in both a diabetic rat and an acute porcine wound model without any secondary tissue damages. The present study demonstrates that the GUFO oxydevice holds promise as a practically feasible candidate for wound treatment.
Synthesis of Clean Hydrogen Gas from Waste Plastic at Zero Net Cost
Authors: Wyss Kevin M. , Silva Karla J. , Bets Ksenia V. , Algozeeb Wala A. , Kittrell Carter , Teng Carolyn H. , Choi Chi Hun , Chen Weiyin , Beckham Jacob L. , Yakobson Boris I. , Tour James M. 
Published: September 2023

AbstractHydrogen gas (H2) is the primary storable fuel for pollution‐free energy production, with over 90 million tonnes used globally per year. More than 95% of H2 is synthesized through metal‐catalyzed steam methane reforming that produces 11 tonnes of carbon dioxide (CO2) per tonne H2. “Green H2” from water electrolysis using renewable energy evolves no CO2, but costs 2–3× more, making it presently economically unviable. Here catalyst‐free conversion of waste plastic into clean H2 along with high purity graphene is reported. The scalable procedure evolves no CO2 when deconstructing polyolefins and produces H2 in purities up to 94% at high mass yields. The sale of graphene byproduct at just 5% of its current value yields H2 production at a negative cost. Life‐cycle assessment demonstrates a 39–84% reduction in emissions compared to other H2 production methods, suggesting the flash H2 process to be an economically viable, clean H2 production route.