bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extramedullary Disease of the Breast in Multiple Myeloma—An Uncommon Initial Presentation: A Case Report and Review of Literature
Authors: Venkataraman Priyadarshini , Mehra Nikitha , Sundersingh Shirley , Iyer Priya 
Published: January 2025

AbstractMultiple myeloma (MM) is a malignancy characterized by the abnormal proliferation of plasma cells within the bone marrow. It is typically defined by the presence of ≥10% clonal bone marrow plasma cells and is associated with hypercalcemia, renal failure, anemia, or lytic bone lesions. Extramedullary disease (EMD) in MM, where plasma cells proliferate outside the bone marrow, is rare. While several case reports on the solitary plasmacytoma of the breast have been reported in the literature, EMD in the breast as an initial presentation of MM is exceedingly rare. We report the case of a 32-year-old female who initially presented to the outpatient department with a lump in her left breast, persisting for 2 months, with no other associated symptoms. Upon evaluation, she was diagnosed with MM International Staging System stage II EMD. The patient underwent standard treatment along with consolidative radiation therapy targeting the breast mass. She achieved a very good partial response (VGPR) and remains in VGPR. Given the rarity of EMD as an initial presentation in MM, the role of radiation therapy in its management remains unclear. In this case report, we utilized radiation therapy as a consolidative treatment with a suitable outcome.
Perioperative Outcomes of Postmenopausal Women with Colorectal Cancer Undergoing Prophylactic Salpingo-oophorectomy
Authors: Schoenmaker Eveline M. , van Zon Jasper F. J. A. , Heijmans Margot H. M. , Bloemen Johanne G. , Lettinga Tanja , de Waard Jan-Willem D. , Roumen Rudi M. H. 
Published: January 2025

Objectives Women with colorectal cancer have an increased risk of developing ovarian malignancies, which have a poor prognosis. Shared decision making on the possibility of prophylactic salpingo-oophorectomy (PSO) during colorectal cancer surgery in postmenopausal women has, therefore, been implemented. Effects of PSO on perioperative parameters are unknown. This study therefore compares perioperative parameters between women with and without PSO.
Materials and Methods Women undergoing colorectal cancer surgery between January 2020 and March 2023 in four centers in the Netherlands offering the possibility of PSO were included. Perioperative parameters were compared between the group with and without PSO.
Statistical Analysis Continuous data were analyzed with independent t-tests or nonparametric tests when applicable. Categorical variables were analyzed with chi-square tests. Propensity score matching was performed to control for potential confounders. The variables age, American Society of Anesthesiologists classification, TNM stages, and type of surgery were used as respective covariates. Perioperative data were again analyzed between the matched groups. A sensitivity analysis including all participants was performed to evaluate the effect of PSO on duration of admission and on complications.
Results The present study included 112 women who underwent PSO and 28 who did not. The PSO group was significantly younger (median: 74 vs. 79 years, p = 0.002), had a shorter hospital stay (median: 4 vs. 6 days, p = 0.006), and experienced less overall postsurgical complications (31 vs. 64%, p = 0.002). These differences were neither observed after propensity score matching nor after sensitivity analysis. Malignant adnexal tissue was identified in three patients.
Conclusion PSO in combination with elective colorectal cancer surgery in postmenopausal women does not lead to different or worse perioperative outcomes compared with the group without PSO. Nonetheless, the decision to undergo this combined surgery should be made on individual basis. Future research needs to focus on long-term follow-up and generalizability.
Aquafilling Filler for Buttock Augmentation Cause Severe Long-Term Complications: A Case Report
Authors: Kristiansen Camilla Soendergaard , Lang Christian Lyngsaa , Haerskjold Ann , Zachariae Claus , Klit Anders 
Published: January 2025

AbstractFiller injections for buttock augmentation are becoming more popular as a cosmetic procedure, which leads to an expected increase in the number of complications emphasizing the importance of reporting cases with both well-known, severe, and previously undiscovered complications, as well as their possible treatment strategies.We present an 18-year-old woman who suffered severe long-term complications following Aquafilling injections for buttock augmentation, including filler migration, infection leading to septic shock, and nonparathyroid hypercalcemia, which has the potential to cause renal insufficiency. To date, we have not found any reports describing the association between nonparathyroid hypercalcemia and Aquafilling. Additionally, we outline a treatment regimen involving a minimally invasive approach, which includes daily irrigation, manual compression, and passive evacuation. At follow-up, the patient returned to her everyday life with no lasting sequelae, except for a solid mass medially on the right thigh.
Genome-Wide Analysis of the CsAP2/ERF Gene Family of Sweet Orange (Citrus sinensis) and Joint Analysis of Transcriptional Metabolism under Salt Stress
Authors: Zhang Mengjie , Zi Yinqiang , Yang Xiujia , Yang Xiuyao , Zhu Ling , Cai Hanbing , Yin Tuo , Liu Xiaozhen , Zhang Hanyao 
Published: January 2025

Abstract

Background
Sweet orange is an important economic crop, and salt stress can inhibit its growth and development.

Methods
In this study, we identified AP2/ERF genes in sweet orange via bioinformatics and performed a combined transcription‒metabolism analysis, which revealed for the first time the integrated molecular mechanism of salt stress regulation in sweet orange.

Key results
A total of 131 sweet orange AP2/ERF genes were identified and categorized into five groups. By comparing the tertiary protein structures of these genes with those of Arabidopsis, we found that five sweet orange genes (CsERF38, CsERF41, CsERF42, CsERF84, and CsERF110) related to salt stress and ethylene transcription are highly similar in composition and structure to those of Arabidopsis, and we hypothesize that they have similar functions. ABREs and AREs were the predominant cis-acting elements in the sweet orange AP2/ERF gene family, and both were associated with salt stress. The AP2/ERF gene family was verified to be involved in the salt stress response via qRT-PCR. According to the differentially abundant metabolite KEGG network, we chose the differentially abundant metabolites ET, GA, and JA as the primary research objects; the CsAP2/ERF gene family is an ethylene-responsive element binding factor.

Conclusion
In this study, the complete framework of the AP2/ERF gene family was constructed for the first time. A model of salt stress regulation in sweet oranges was established.
Ericaceous dwarf shrubs in drained forested peatlands: distribution, dynamics, and key factors in a restoration experiment
Authors: Tekko Triin , Lõhmus Asko 
Published: January 2025

Abstract
Ericaceous dwarf shrubs comprise a key component of the vegetation in several types of northern peatlands. Widespread draining of the peatlands is known to favour forest species (such as Vaccinium myrtillus and Vaccinium vitis-idaea) over mire species (such as Andromeda polifolia and Vaccinium oxycoccos), but it is unclear to what extent such assemblage shifts should form a target for ecological restoration. In this paper, we analyse the performance of eight co-occurring dwarf shrub species in a large-scale ecological restoration experiment in Scots pine-dominated wetlands that had been drained over 40 years ago in Estonia. We address two related questions: (1) how major ecosystem-change-related factors and within-assemblage interactions affect the 1-m2 scale presence of each species in the drained landscape, and (2) to what extent their cover responses to ditch blocking and partial harvest over 6 years reveal a reversal of the drainage-caused succession. We explored those factors and the treatment effects using general linear mixed modelling of the species’ presence and cover. At least four species were responding negatively to drainage, predominantly along with the stand successional stage. However, the results infer that most species were probably enhanced in the early post-drainage phase. The presence of each species was independently enhanced by the presence of other species; the only antagonistic relationship found was between V. myrtillus and V. uliginosum. Ditch blocking had a clear effect only on V. oxycoccos, which increased along with Sphagnum moss cover. In several species, we found a temporary decline in some treatments. Overall, the ericaceous shrub cover appeared rather resistant to the fundamental environmental changes investigated and it may serve as a relatively stable functional component both in natural and anthropogenic peatland transitions. In addition to clone longevity, the facilitative mechanisms suggested by co-occurrence patterns may play a role in this and deserve further study.
Examining Electronic Nicotine Delivery System (ENDS) Cue Reactivity Using a Remote Platform: Cigarette and ENDS Desire in Dual Users
Authors: Miloslavich Krista , Brett Emma I , Fridberg Daniel J , King Andrea C 
Published: January 2025

Abstract

Introduction
Prior research shows that in-person exposure to electronic nicotine delivery systems (ENDS) use increases the desire for cigarettes and ENDS. However, less is known about the impact of cues delivered during remote interactions. This study extends previous in-person cue work by leveraging a remote confederate-delivered cue-delivery paradigm to evaluate the impact of dual nicotine vaping (vs. sole smoking) on reactivity to an ENDS cue in individuals who smoke cigarettes.

Methods
N = 52 dual users (DU; current users of both combustible cigarettes and ENDS) and N = 54 sole smokers (SS; users of combustible cigarettes only) observed a study confederate drinking bottled water (control cue) and then vaping an ENDS (active cue). Changes in desire for cigarettes and ENDS were compared between groups post-cue exposure.

Results
Multilevel models, controlling for sex and cigarettes per day, revealed that the remote ENDS cue, but not water, significantly increased the desire for both cigarettes and ENDS. Relative to SS, DU reported greater post-ENDS cue increases in ENDS desire but not cigarette desire.

Conclusions
A remote, confederate-delivered ENDS cue generalizes as a smoking and vaping cue, with DU showing greater reactivity than SS. This study provides the first evidence for the validity and feasibility of a remote, confederate-delivered ENDS cue reactivity paradigm.

Implications
This study provides support for the use of a remote platform, an increasingly popular method of conducting research since the onset of the COVID-19 pandemic, to employ confederate-delivered ENDS cues. Frequent observations of vaping via remote platforms and social media may contribute to the maintenance of single- and dual-product use.
ERP correlates of agency processing in joint action
Authors: Hughes Gethin , Gooding Peter Leslie Thomas 
Published: January 2025

Abstract
In the Ouija board phenomenon, the lack of agency experienced by the players leads them to attribute the movement of the planchette to spirits. The aim of this study was to investigate the neural and cognitive mechanisms involved in generating the sense of agency in such a joint action context. Two players (a participant and a confederate) jointly moved a Ouija board-style planchette containing a wireless mouse. This, in turn, moved a digital board on the screen. Participants reported a greater sense of agency in the condition where they had complete control of the planchette (the ‘self’ condition), and least agency when they passively held the planchette while it was moved by the confederate (‘other’ condition), with the two ‘joint’ action conditions in between. While the N1 peak did not differ between conditions, the early part of the N1 differentiated between the joint action conditions, and the solo action conditions. In contrast, the Tb and P2 components differed between the ‘other’ condition and the ‘self’ and ‘joint’ conditions. These findings are discussed with reference to motor-prediction and attentional mechanisms.
Lacrimal sac rhinosporidiosis presented as nasal obstruction symptoms without any ocular manifestations: a case report
Authors: Paneru Manisha , Yadav Deepak , Yadav Dhirendra 
Published: January 2025

Introduction and importance:
Rhinosporidiosis is a chronic granulomatous infection due to Rhinosporidium seeberi and it is endemic mainly in South Asian countries such as India and Sri Lanka. Though it commonly involves nasal and nasopharyngeal mucosa, the involvement of the lacrimal sac is rare. Diagnosis can be done by imaging techniques and confirmed on histopathology.

Case presentation:
A 22-year-old male presented with left nasal obstruction and an oropharyngeal mass, without any ocular symptoms. Imaging studies by CT scan revealed a mass involving the nasal and nasolacrimal regions. Biopsy confirmed rhinosporidiosis. The patient underwent a wide local excision of the mass with partial resection of the lacrimal sac. Postoperatively, the patient was given Dapsone for 6 months. Regular follow-up with nasal endoscopy and ophthalmology review showed no evidence of recurrence 1 year following surgery.

Clinical discussion:
Rhinosporidiosis typically presents as vascular polyps in the nasal or ocular areas. It is uncommon that there might be involvement of the lacrimal sac without any symptomatology relevant to the conjunctiva, which has been elaborated in the present case. Examination for the extent of disease is assisted by techniques such as CT and MRI. Histopathology is confirmatory, showing a typical appearance with sporangia filled with multiple endospores. Treatment can be carried out mainly by surgical excision supplemented by electro-coagulation to avoid recurrence. Dapsone post-operatively is recommended as recurrence is common in rhinosporidiosis.

Conclusion:
Although rhinosporidiosis predominantly affects the nasal mucosa, lacrimal sac involvement should be considered in the differential diagnosis. Surgical excision along with postoperative medication and regular follow-up forms the mainstay in the management of the disease to avoid recurrence.
Perioperative bowel regimens following posterior spinal fusions for adolescent idiopathic scoliosis: a systematic review
Authors: Benaroch Lee R. , Ahmadi Pirshahid Ali , Morash Kevin , Singh Supriya , Rasoulinejad Parham , Bartley Debra , Carey Timothy , Iansavichene Alla , Thornley Patrick 
Published: January 2025

Background:
Bowel morbidity after posterior spinal fusions (PSFs) for adolescent idiopathic scoliosis (AIS) delays the advancement of postoperative oral diet and discharge. This systematic review aims to investigate the effectiveness of perioperative bowel regimens in reducing length of stay and postoperative bowel morbidity in these patients.

Materials and methods:
We systematically searched MEDLINE, Embase, Cochrane, SPORTDiscus, and CINAHL for articles reporting on clinical results of PSFs for AIS patients. Demographic data, mean operative time and estimated blood loss, length of stay, time to first flatus and/or bowel movement, first oral intake, and postoperative pain scores were extracted from the selected studies.

Results:
Six articles (n = 468 patients) met the final inclusion criteria. Only one study, which assessed oral methylnaltrexone, reported a significant reduction in the mean hospital length of stay (0.60 days, P < 0.05) and postoperative abdominal distension (17% versus 40%, P < 0.05); however, it was also the only study to report a significantly increased mean operative time (38.9 min, P = 0.03) and estimated blood loss (111.1 mL, P = 0.05) compared to the treatment group. Time to flatus, regular diet, postoperative opioid consumption, and pain scores did not differ significantly in any of the reported studies.

Conclusion:
There is limited evidence to demonstrate any specific perioperative bowel regimen will decrease postpreparative bowel morbidity and/or length of stay. While not a treatment in isolation, oral methylnaltrexone may be a safe and effective adjunct to standard postoperative bowel regimens and may have a better patient tolerance profile.
Robot-assisted anterior resection of rectal cancer in a patient with abdominal aortic aneurysm using a monitoring laparoscope: a case report
Authors: Takashima Junpei , Kobayashi Hirotoshi , Koizumi Ayaka , Shigehara Fumi , Yamazaki Kenji , Fujimoto Daisuke , Miura Fumihiko , Taniguchi Keizo 
Published: January 2025

Introduction and importance:
We present the first case of robot-assisted anterior resection for rectal cancer in a patient with abdominal aortic and common iliac aneurysms using a monitoring laparoscope for enhanced safety.

Case presentation:
An 86-year-old man presented with bloody stool and was diagnosed with Stage IIIB rectal cancer (T3N1aM0). Preoperative computed tomography revealed a 39-mm abdominal aortic aneurysm and 25-mm left common iliac aneurysm. Robot-assisted anterior resection with D2 lymph node dissection was performed using a 5-mm laparoscope to avoid contact between robotic forceps and aneurysm. The procedure was successful, and he was discharged from the hospital on the ninth postoperative day.

Clinical discussion:
Robotic surgery, owing to the lack of tactile sensation, is generally contraindicated in cases of abdominal aortic aneurysms because of the risk of vascular injury. However, this case demonstrates that real-time monitoring with a 5-mm laparoscope can effectively prevent accidental vascular injury during robotic surgery for rectal cancer.

Conclusion:
This case illustrates the appropriate modifications by which robotic surgery for rectal cancer can be safely performed in patients with abdominal aortic or common iliac artery aneurysms.
Gastroduodenal intussusception: two cases of gastroduodenal intussusception following gastric plication, each managed with a different approach: a case report
Authors: Almowaqee Bassel , Madi Yamen , Taleb Bushra , Haj Oughli Mhd Adnan 
Published: January 2025

Introduction and importance:
Gastric plication is a bariatric procedure that involves suture imbrication of the greater curvature to restrict the volume of the stomach. Although gastroduodenal intussusception is a complication that surgeons may encounter in their practice, it is rarely reported or published, which limits the available knowledge in medical literature.

Case presentation:
The authors report two female patients who developed gastroduodenal intussusception following gastric plication procedure, requiring surgical treatment. Both patients presented with non-specific, atypical abdominal pain several months after gastric plication. Both patients required surgical intervention, which included manual reduction of the plication followed by subtotal gastrectomy en bloc with Roux-en-Y reconstruction. In the second case, an omega Braun anastomosis was performed, and a jejunostomy was created after the anastomosis in both patients.

Clinical discussion:
The optimal management of gastroduodenal intussusception remains challenging due to the lack of reported cases and the technical difficulties that surgeons may face.

Conclusion:
It appears that we will encounter some problems and complications in the present time and the near future, including some that are rare in bariatric surgery, particularly those procedures that have fallen out of favor, such as gastric plication surgery.
Atypical hyperendemicity of Rift Valley fever in Southwestern Uganda associated with the rapidly evolving lineage C viruses
Authors: Bakamutumaho Barnabas , Juma John , Clancey Erin , Nyakarahuka Luke , Situma Silvia , Odinoh Raymond , Dawa Jeanette , Nasimiyu Carolyne , Eskew Evan A. , Balinandi Stephen , Mulei Sophia , Kayiwa John , Klena John D. , Shoemaker Trevor R. , Whitmer Shannon L.M. , Montgomery Joel M. , Schieffelin John , Lutwama Julius , Muruta Allan , Bosa Henry Kyobe , Nuismer Scott L. , Oyola Samuel O. , Breiman Robert F. , Njenga M. Kariuki 
Published: January 2025

AbstractIntroductionRecent Rift Valley fever (RVF) epidemiology in eastern Africa region is characterized by widening geographic range and increasing frequency of small disease clusters. Here we conducted studies in southwestern (SW) Uganda region that has since 2016 reported increasing RVF activities.MethodsA 22-month long hospital-based study in three districts of SW Uganda targeting patients with acute febrile illness (AFI) or unexplained bleeding was followed by a cross-sectional population-based human-animal survey. We then estimated RVFV force of infection (FOI) and yearly cases using the age-structured seroprevalence data and conducted genomic phylodynamic modelling of RVFV isolates.ResultsOverall RVF prevalence was 10.5% (205 of 1,968) among febrile or hemorrhagic cases, including 5% with acute (PCR or IgM positive) infection, averaging 5 cases per month. Community-based serosurvey recorded prevalence of 11.8% (88 of 743) among humans and 14.6% (347 of 2,383) in livestock. Expected yearly human RVF cases were 314-2,111 per 1,369 km2in SW Uganda versus 0-711 in comparable regions of Kenya and Tanzania. Viral genomic studies identified RVFV lineage C, sub-clade C.2.2, as the circulating strain in SW Uganda since 2019. Lineage C strain has undergone recent rapid evolution and clonal expansion resulting in four sub-clades, C.1.1, C.1.2, C.2.1, and C.2.2, that are more adept at establishing endemicity in new territories.ConclusionsWe demonstrate an atypical RVF hyperendemic region in SW Uganda characterized by sustained human clinical RVF cases, unusually high population prevalence, and high number of expected yearly human cases, associated in part with emergence of new RVFV sub-lineages.Key pointsRift Valley fever (RVF) studies in SW Uganda found atypical sustained human cases averaging 5 cases/month, >10% population prevalence, and expected yearly cases >3-fold higher (314-2,111 vs 0-711) than comparable regions in East Africa, associated with emerging RVFV sub-lineages.
A Two-Heads-Bound State Drives KIF1A Superprocessivity
Authors: Rao Lu , Wirth Jan O. , Matthias Jessica , Gennerich Arne 
Published: January 2025

AbstractKIF1A, a neuron-specific Kinesin-3 motor, is indispensable for long-distance axonal transport and nuclear migration, processes vital for neuronal function. Using MINFLUX tracking, we reveal that KIF1A predominantly adopts a two-heads-bound state, even under ATP-limiting conditions, challenging prior models proposing a one-head-bound rate-limiting step. This two-heads-bound conformation, stabilized by interactions between the positively charged K-loop and negatively charged tubulin tails, enhances microtubule affinity and minimizes detachment. The shorter neck linker facilitates inter-head tension, keeping the heads out of phase and enabling highly coordinated stepping. In contrast, Kinesin-1 (KIF5B) transitions to a one-head-bound state under similar conditions, limiting its processivity. Perturbing KIF1A’s mechanochemical cycle by prolonging its one-head-bound state significantly reduces processivity, underscoring the critical role of the two-heads-bound state in motility. These findings establish a mechanistic framework for understanding KIF1A’s adaptations for neuronal transport and dysfunction in neurological diseases.