bluuebunny/crossref_metadata_2025_split huggingface dataset:
BiliBin: An Intelligent Mobile Phone-based Platform to Monitor Newborn Jaundice
Authors: Zarehpour Eisa , Mohammadi Mohammad Reza , Zakeri-Nasrabadi Morteza , Aein Sara , Sangsari Razieh , Taheri Lila , Zabihallahpour Ali , Rohi Iraj 
Published: January 2023

Abstract

Using mobile phones for medical applications are proliferating due to high-quality embedded sensors. Jaundice, a yellow discoloration of the skin caused by excess bilirubin, is a prevalent physiological problem in newborns. While moderate amounts of bilirubin are safe in healthy newborns, extreme levels are fatal and cause devastating and irreversible brain damage. Accurate tests to measure jaundice require a blood draw or dedicated clinical devices facing difficulty where clinical technology is unavailable. This paper presents a smartphone-based screening tool to detect neonatal hyperbilirubinemia caused by the high bilirubin production rate. A machine learning regression model is trained on a pretty large dataset of images, including 446 samples, taken from newborns' sternum skin in four medical centers in Iran. The learned model is then used to estimate the level of bilirubin. Experimental results show a mean absolute error of 1.807 and a correlation of 0.701 between predicted bilirubin by the proposed method and the TSB values as ground truth.
Ventral anchoring of the conus medullaris: a new surgical technique preventing the recurrence of retethering after surgery for tethered spinal cord
Authors: Morota Nobuhito , Ihara Satoshi , Inukai Madoka , Kuroha Masae 
Published: January 2023

Abstract
Objective: Retethering is not an unusual operation for a congenital lumbosacral dysraphic spinal lesion. The present study aimed to assess a new surgical technique for preventing retethering.
Surgical technique: After untethering the spinal cord, the pia mater or scar tissue at the caudal end of the conus medullaris is anchored to the ventral dura mater loosely using 8-0 thread, and the dura mater is closed directly. This technique is called ventral anchoring.
Results: Ventral anchoring was performed in 15 patients (aged 5 to 37 years old, average age: 12.1 years old) between 2014 and 2021. All but one patient showed improvement or stabilization of the preoperative symptoms. No complication directly related to the procedure was observed. Postoperative MRI demonstrated that the dorsal subarachnoid space was restored in 14 patients but was undetectable or absent in three patients on follow-up MRI. No patients have experienced a recurrence of the tethered cord syndrome during the follow-up period.
Conclusion: Ventral anchoring is effective for restoring the dorsal subarachnoid space after untethering the spinal cord. This preliminary study suggested that ventral anchoring has the potential to prevent the postoperative recurrence of tethered cord syndrome in patients with a congenital lumbosacral dysraphic spinal lesion.
Powered Air-Purifying Respirator (PAPR) and High-Efficiency Particulate Air (HEPA) Buggies to Improve COVID-19 Safety for the Youngest Children: Evaluation of Prototypes
Authors: Hoerger Michael 
Published: January 2023

Abstract

Introduction: Young children are susceptible to COVID-19 infection in high-risk settings because they cannot begin vaccination until at least 6 months old and cannot mask safely until at least 2 years old. During essential activities, parents have attempted to protect children in strollers using rain covers, but these provide limited protection against airborne transmission. The investigator examined various models of rain-covered strollers that used either PAPR or HEPA air cleaning devices to provide safer air, so-called “PAPR buggies” and “HEPA buggies.” Materials and Method The investigation examined six models that varied based on the type of air filter, (PAPR, small/large HEPA), stroller, and rain cover, and the number of children (single or twin). Key outcomes were a qualitative assessment of strengths and limitations, air flow metrics, and sound intensity. Although all models used safe commercially-sold rain covers, the smallest model was also tested for air quality. Results The investigator evaluated each model as acceptable. The PAPR buggies are discrete, whereas the HEPA buggies offer greater flexibility in price and air flow rates. Models had a median of 185.26 air changes per hour, ACH (range of 57.22-951.33), equivalent to 12.35 times the standard for U.S. operating rooms (range of 3.81–63.42). Sound intensity was equivalent to a conversation or office setting (55.5–64.6 dB). Air quality testing revealed no safety concerns. Costs are reasonable for many families. Discussion PAPR and HEPA buggies are additional tools families can use as a part of a multifaceted strategy to improve safety in high-risk settings during the COVID-19 pandemic. The models evaluated were reasonable, provided excellent air flow, and had tolerable sound levels. There were no safety concerns, though parents are cautioned to only use commercially-sold, safe rain covers. The investigator offers suggestions for disseminating the widespread use of PAPR and HEPA buggies.
On softmultiset filter of a residuated lattices and its application in decision making problem
Authors: VS Anusuya Ilamathi 
Published: January 2023

Abstract
In this work, the study on new theoretical developments and links between the residuation and the hyperstructure called softmultisets is focused. The relation between softset filter and softmultiset had been exposed. The concepts of softmultiset filter of a residuated lattice is introduced and many of its results are established. Following this an application of softmultiset filter in a decision making problem is presented.
MSC 2010: 06B10 ; 06D72; 08A72.
Sea-ice decline makes zooplankton stay deeper for longer
Authors: Flores Hauke , Veyssiere Gaelle , Castellani Giulia , Wilkinson Jeremy , Hoppmann Mario , Karcher Michael , Valcic Lovro , Cornils Astrid , Geoffroy Maxime , Nicolaus Marcel , Niehoff Barbara , Priou Pierre , Schmidt Katrin , Stroeve Julienne 
Published: January 2023

Abstract
As Arctic sea ice deteriorates, more light enters the Arctic Ocean, causing largely unknown effects on the ecosystem. A novel autonomous bio-physical observatory provided the first record of zooplankton vertical distribution under sea ice drifting across the Arctic Ocean from dusk to dawn of the polar night. Its measurements revealed that zooplankton ascend into the under-ice layer during autumn twilight, following an isolume of 5.5 10-4 W m-2. We applied this trigger isolume to IPCC models enabled to incorporate incoming radiation after sunset and before sunrise of the polar night. The models project that, in about three decades, the total time spent by zooplankton in the under-ice layer will be reduced by up to one month, depending on geographic region. This will impact zooplankton winter survival, the Arctic foodweb, carbon- and nutrient fluxes. These findings highlight the importance of processes in the twilight periods for predicting change in high-latitude ecosystems.
Edible exosome-like nanoparticles from Portulaca oleracea L prevent DSS-induced colitis via the promotion of double-positive CD4 + CD8 + T cells
Authors: Zhu Min-zheng , Xu Hao-ming , Liang Yu-jie , Xu Jing , Yue Ning-ning , Zhang Yuan , Tian Cheng-mei , Yao Jun , Wang Li-sheng , Nie Yu-qiang , Li De-feng 
Published: January 2023

Abstract

Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the treatment of ulcerative colitis (UC). As a proof of concept, we show that Portulaca oleracea L-derived exosome-like nanoparticles (PELNs) are isolated and identified from edible Portulaca oleracea L with desirable nano-size (~ 160 nm) and a negative zeta potential value (-31.4mV). Moreover, we find that oral administration of PELNs can suppress the expressions of pro-inflammation cytokines (TNF-α, IL-6, IL-12, and IL-1β), and increase the levels of anti-inflammatory cytokine (IL-10) in dextran sulphate sodium (DSS)-induced mice and PHLPP2−/−mice spontaneous colitis contributing to alleviate colitis. Furthermore, orally administered PELNs can display great stability in gastrointestinal tract environment, and specifically targeted to desired inflammatory site in mice colitis. In addition, oral administration of PELNs can effectively maintain the diversity and balance of gut microbiota, and specifically induce the differentiation of double-positive CD4+CD8+T cells (DP CD4+CD8+T cells). In summary, our findings suggest that orally administered PELNs brings a novel and natural colon-targeted agent, and open a new therapeutic avenue in the management of UC.
Facile Green Synthesis of Carbon Dots and Their Utility for Electrochemical Sensing and Binding of a Flavanone, Hesperetin
Authors: Tandel Ranjita D. , Seetharamappa J. 
Published: January 2023

Abstract

In the present work, we have developed environmental friendly and sensitive electrode material, carbon dots modified glassy carbon electrode (C-dots/GCE) for analytical and binding applications of a flavanone, hesperetin (HES). C-dots were prepared and characterized by different techniques. Factors affecting the activity of sensing interface were examined and optimized for sensitive performance. The fabricated C-dots/GCE displayed high effective surface area, more reactive sites and excellent conductivity towards the oxidation/reduction of HES. HES exhibited about 20-fold enhancement in the oxidation peak current at C-dots/GCE compared to that at bare GCE. Under the optimized conditions, a linear relationship between the oxidation peak current and concentration of HES was observed in the range of 0.05–62.5 µM for differential pulse voltammetric, 0.01–125 µM for square wave voltammetric and 10–62 µM for adsorptive stripping differential pulse voltammetric methods, respectively. Further, the proposed sensor was applied successfully for the determination of HES in biological samples.
Beamforming antenna array with circular polarization for an RF energy recovery system on a UAV
Authors: Ihlou Salah , Tizyi Hafid , Bakkali Abdelmajid El , Abbassi Ahmed El , Dahbi Aziz 
Published: January 2023

Abstract
In this research, we suggested a novel beamforming antenna array for RF energy recovery applications that incorporates pattern and polarization diversity. Experiments are used to validate the proposed structure’s performance once it has been modelled and optimized. This suggested structure provides an impedance bandwidth of 5.5 to 6 GHz, according to calculated measurements. The antenna system can create four circular polarization diversity beams at ± 15 and ± 45 by switching the input port; two of them have left-hand circular polarization and the other two have right-hand circular polarization. Furthermore, radiation patterns with low cross-polarization, excellent axial ratio around the center frequency, and low envelope correlation coefficient are achieved across the working spec-trum. Energy recovery applications have recorded gains of 5.3 and 6.6 dBi. The design and all circuits ‘simulation as well as the 5.8 GHz antenna array are carried out using ADS and CST software. All transmission line; widths and lengths; (50Ω characteristic impedance) are calculat-ed and optimized respectively using the LineCalc tool and the Tuning function.
3-dimensional analysis of hard- and soft-tissue symmetry in a Chinese population
Authors: Zhao Jiamin , Xu Yifei , Wang Jinxiu , Lu Zhen , Qi Kun 
Published: January 2023

Abstract
Background
Facial symmetry severely affects appearance and function. Large numbers of patients seek orthodontic treatment to improve facial symmetry. However, the correlation between hard- and soft-tissue symmetry is still unclear. Our aim was to investigate the hard- and soft-tissue symmetry in subjects with different levels of menton deviation and sagittal skeletal classes with 3D digital analysis and to investigate the relationship between the entire and individual hard- and soft-tissues.
Methods
A total of 270 adults (135 males and 135 females) consisting of 45 subjects of each sex in each sagittal skeletal classification group. All subjects were further classified into relative symmetry (RS), moderate asymmetry (MA) and severe asymmetry (SA) groups based on the degree of menton deviation from the mid-sagittal plane (MSP). The 3D images were segmented into anatomical structures and mirrored across the MSP. Original and mirrored images were registered by a best-fit algorithm, and the corresponding root mean square (RMS) values and colormap were obtained. The Mann‒Whitney U test and Spearman correlation were conducted for statistical analysis.
Results
The RMS increased with greater deviations with regard to the deviation of the menton in most of anatomical structures. Asymmetry was represented in the same way regardless of sagittal skeletal pattern. The soft-tissue asymmetry had a significant correlation with dentition in the RS group (0.409), while in the SA group, it was related to the ramus (0.526) and corpus (0.417) in males and was related to the ramus in the MA (0.332) and SA (0.359) groups in females.
Conclusions
The mirroring method combining CBCT and 3dMD provides a new approach for symmetry analysis. Asymmetry might not be influenced by sagittal skeletal patterns. Soft-tissue asymmetry might be reduced by improving the dentition in individuals with RS group, while among those with MA or SA, whose menton deviation was larger than 2 mm, orthognathic treatment should be considered.
Liver-derived extracellular vesicles from patients with hepatitis B virus-related acute-on-chronic liver failure impair hepatic regeneration by inhibiting on FGFR2 signaling via miR-218-5p
Authors: Zhang Senquan , Yu Jie , Rao Keqiang , Cao Jie , Ma Lijie , Yu Yeping , Li Zhe , Zeng Zhaokai , Qian Yongbing , Chen Mo , Hang Hualian 
Published: January 2023

Abstract
Background: Impaired liver regeneration in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients is closely related to prognosis, whereas the mechanisms are not yet defined. Liver-derived extracellular vesicles (EVs) may be involved in dysregulation of liver regeneration. Clarifying the underlying mechanisms will contribute to the development of improved treatments for HBV-ACLF.
Methods: EVs were isolated by ultracentrifuge from liver tissues of HBV-ACLF patients (ACLF_EVs) after liver transplantation and their Function was investigated utilizing acute liver injury (ALI) mice and AML12 cells. Differentially expressed miRNAs (DE-miRNAs) were screened by deep miRNA sequencing. LNP system was applied as a carrier for targeted delivery of miRNA inhibitors to improve their effect on liver regeneration.
Results: ACLF_EVs had the capacity to inhibit hepatocyte proliferation and liver regeneration, in which miRNA, especially miR-218-5p, played an important role. Mechanistically, ACLF_EVs fused directly with target hepatocytes and transferred miR-218-5p into hepatocytes, acting by suppressing FGFR2 mRNA and inhibiting the activation of ERK1/2 signaling pathways. Reducing the level of miR-218-5p expression in the liver of ACLF mice could partially restored liver regeneration ability.
Conclusion: Our data reveals the mechanism underlying impaired liver regeneration in HBV-ACLF and has significance for the discovery of new therapeutic approaches.
WITHDRAWN: Structural, spectroscopic, cell viability, Anti-bacterial studies on PVC/PVDF doped by AgNPs via laser ablation for wound healing application
Authors: Menazea A. A. , El-Bahnasy S. S. , Ayad D. M. 
Published: January 2023

Abstract
Altering films structures to be utilized in wound healing applications is crucially needed to enhance quality of life. Different contributions of silver nanoparticles fabricated via laser ablation have been incorporated in (30% PVC/70% PVDF) blend. Changes in the structural, optical, and antibacterial property of the PVC/PVDF mixture prior to and after the incorporation of Ag were investigated using various techniques. FTIR shows vibrational spectral bands established a link between polymers and nanoparticles. XRD results approved the clear observation of the high concentration of silver nanoparticles in the last sample according to the peak at 38.42̊. UV-Visible analysis confirms the construction of AgNPs at 234 nm and the optical absorption edges were noticed for all of the obtained samples. SEM is employed to prove the generation of silver nanoparticles inside the solution utilizing laser ablation besides its dispersion in PVC/PVDF blend. The bacterial activity of AgNPs shows high activity index values at higher concentration of AgNPs. Blended PVC/PVDF/AgNPs could be suggested for wound healing applications. The values of the cell viability and antibacterial activity of the fabricated PVC/PVDF/AgNPs NPs films suggest these samples for utilization for biomedical applications as wound healing application.
Childhood trauma, peer victimization, and non-suicidal self-injury among Chinese adolescents: A latent variable mediation analysis
Authors: Zhao Ke , Tong Siyu , Yang Shuang , Yang Wenyun , Xu Yao , Fan Zilin , Hong Lan , Zheng Jiaqi , Yao Keqing , Zheng Tiansheng 
Published: January 2023

Abstract
Backgrounds: Childhood and peer experiences can influence adolescents' perceptions of interpersonal relationships, which can, in turn, influence their emotional states and behavior patterns. Non-suicidal self-injury (NSSI) is now a common problem behavior among adolescents. The present study examined the role of childhood trauma and peer victimization in adolescents’ NSSI.
Methods: A cross-sectional survey was conducted among 1783 adolescents (1464 girls and 318 boys) in the psychiatric outpatient clinics or wards of 14 psychiatric hospitals or general hospitals in nine provinces in China. Data were collected using the Multidimensional Peer Victimization Scale (MPVS), Short-form Childhood Trauma Questionnaire(CTQ-SF), and Functional Assessment of Self-Mutilation (FASM). Structural equation modeling (SEM) with latent variables was used to demonstrate the mediating role of peer victimization in the association between childhoodtrauma and NSSI.
Results: The SEM analysis demonstrated that peer victimization plays a partial mediating role in the relationship between childhood trauma and NSSI. . In addition, several covariates (such as age, gender, education level, and place of residence) effectively regulated the relationship between peer victimization and NSSI.
Conclusions: In future studies of NSSI among Chinese adolescents, attention should be paid to the roles of childhood trauma and peer bullying; there is a temporal sequence between these two variables and, to some extent, childhood trauma can have an impact on bullying during adolescence which, in turn, influences NSSI behavior.
Identification and characterization of peptides from marine crustacean crabs and their bioactive properties; An approach to develop novel drugs for Alzheimer’s disease
Authors: Bakthavachalam Dhivya , Arumugam Sivakumar 
Published: January 2023

Abstract
Peptide-based drugs have become the most promising drug therapy in the pharmaceutical industry. It accommodates a major part in treating diseases like neurodegenerative disorders, type 2 diabetes, blood pressure, etc. This study aims to isolate and characterize the marine peptides from the crustacean crab species named Scylla Serrata. The hemolymph was collected and subjected to thin-layer chromatography (TLC) and Fourier Transform Infrared spectroscopy for identifying amine groups. Further the peptide groups in the sample was confirmed by nuclear magnetic resonance analysis. Ultra-performance liquid chromatography (UPLC) for the crude was performed to identify the intensity of the peaks. The sample was further purified with Sephadex G-25 to elute the small molecular peptides. Antioxidant activity (DPPH) for the crude sample showed 55% of activity at 100µg/ml concentration and the fractions showed significant activity. The eluted fractions from the column chromatography were then subjected to SDS PAGE to identify the molecular weight of the peptides in which the peptide bands ranged between 75–100 kDa. Further, the best compounds must be developed as potential drugs for Alzheimer’s disease with an In-silico approach.
Documentation research and digital semantic reproduction of archaeological achievements-A Study of Six Steeds in the Zhaoling of the Tang Dynasty
Authors: Cang Minnan , ZHOU WEI , ZHANG HUI 
Published: January 2023

Abstract

There are many cultural relics in China, but many immovable cultural relics have been damaged due to social changes, time erosion, rogue destruction and archaeological development. Although the cultural relics can be repaired, the cultural, social, political and other semantic factors left behind the cultural relics cannot be deeply interpreted. Therefore, this study aims to take the stone carvings of Zhaoling in the tenth year of Tang Zhenguan as an example, carry out digital scanning measurement and digital reproduction based on semantics, and integrate cultural factors such as literature into digital means, so that users can deeply interpret the context behind cultural relics. Digital measurement applies the combination of technology of laser scanning and digital photogrammetry. After obtaining the 3D data, by searching the literature and extracting the contextual elements related to matching, their structures were systematically analyzed. Through splitting and extraction, many elements are analyzed and digitally reproduced, and finally integrated through digital modelling. Through these methods, all the data and information are recorded, stored, and managed. Research shows that damaged immovable cultural relics can be reconstructed through digital technological means and cultural context, and then recorded, preserved and studied through digital, information and systematic ways.
Study on the characteristics of damaged sandstone in the Longshan Grottoes using water chemistry and freeze-thaw cycling
Authors: Sun Bo , LI Xingyue , CUI Kai , PENG Ningbo , HONG Jie , CHEN Rui 
Published: January 2023

Abstract
Sandstone in the Longshan Grottoes was the research object of this paper. The sandstone samples were soaked in distilled water, Na2SO4 solution and NaCl solution and subjected to 30 cycles of freeze-thaw testing. The quality, wave velocity, surface hardness, uniaxial compressive strength and other physical indices of rock samples were measured after different numbers of cycles. Combined with the results of mercury injection, scanning electron microscopy and X-ray diffraction, the damage characteristics and damage mechanism of rock samples under the combined action of chemical solution and freeze-thaw cycle were explored and studied. The results showed that the degree of damage of the sandstone samples increased logarithmically with an increase in the number of cycles. The damage degree of the sandstone samples soaked in the Na2SO4 solution was the highest, while the damage degree of the samples soaked in the NaCl solution and distilled water was similar. The difference in damage between the solutions is caused by the combination of frost heave, dissolution and salt crystallization, and the damage process generally occurs from the inside and the outside and is manifested as an increase in the number of macropores and the appearance of new pores. Freezing-thawing and salt erosion are the main reasons for the siltation of sandstone in the Longshan Grottoes.