bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidental intraoperative finding of jejunal neuroendocrine tumors during elective ventral hernia repair
Authors: Reed Gasinee , Kim David , Hayes Kelsey , Wirz Richard 
Published: September 2023

Abstract
Neuroendocrine tumors (NETs) constitute ~0.5% of all diagnosed malignancies. In our case, a 72-year-old male, who was asymptomatic aside from mild left lower abdominal pain, was scheduled for elective ventral hernia repair, evident on computed tomography. The laparoscopic ventral hernia repair necessitated the conversion to laparotomy due to extensive adhesions and the incorporation of surgical mesh into the small bowel wall. The patient suffered from delayed small bowel injury resulting in the second emergent laparotomy when numerous calcified lesions were incidentally noted in the small bowel wall. Pathology confirmed Grade 1 well-differentiated NETs of the jejunum. This case highlights the importance of considering NETs as part of a differential diagnosis in patients with nonspecific symptoms and negative imaging studies. This case also emphasizes the importance of early detection of this rare pathology to improve prognosis and outcome.
Epenthesis and vowel intrusion in Central Dhofari Mehri
Authors: Watson Janet C E , Lourido Gisela Tomé , al-Mahri Abdullah 
Published: September 2023

Abstract
The paper discusses epenthesis and vowel intrusion in the Central Dhofari variety of Mehri, one of six endangered Modern South Arabian languages indigenous to southern Arabia. Mehri is spoken by members of the Mahrah tribe in southern Oman, eastern Yemen, parts of southern and eastern Saudi Arabia and in communities in parts of the Gulf and East Africa. The estimated number of Mehri speakers is between 100,000–180,000. Following Hall (2006), this study distinguishes between two types of inserted vowels: epenthetic vowels, which repair illicit syllable structures, and intrusive vowels, which transition between consonants. The paper examines how the properties of epenthetic and intrusive vowels as proposed by Hall relate to Mehri.
Verbal system and poetics in the works of Yehuda Ha-Lewi
Authors: Gryczan Barbara 
Published: September 2023

Abstract
The article analyzes the verbal system in the Hebrew language of Yehuda Ha-Lewi, which is (and was) represented solely by poetry. It points at Ha-Lewi’s poetics, as the central factor shaping his language, whose verbal forms were ascribed additional poetic functions. It aims to define grammatical units and rhetorical techniques which, combined, were used by Ha-Lewi to create his unique poetic style and linguistic system coherent, though seemingly mimicking Biblical Hebrew. Due to the uniqueness of the corpus of the language and the fact that the rhetorical functions were to a large extent ascribed to grammatical forms, in order to define them most accurately, I apply the discursive-pragmatic approach. This method has allowed to outline the matrix of Ha-Lewi’s verbal system and define its innovative features.
Tellurium emission line in kilonova AT 2017gfo
Authors: Hotokezaka Kenta , Tanaka Masaomi , Kato Daiji , Gaigalas Gediminas 
Published: September 2023

ABSTRACT
The late-time spectra of the kilonova AT 2017gfo associated with GW170817 exhibit a strong emission line feature at $2.1\, {\rm \mu m}$. The line structure develops with time and there is no blueshifted absorption feature in the spectra, suggesting that this emission line feature is produced by electron collision excitation. We attribute the emission line to a fine structure line of Tellurium (Te) III, which is one of the most abundant elements in the second r-process peak. By using a synthetic spectral modelling including fine structure emission lines with the solar r-process abundance pattern beyond the first r-process peak, i.e. atomic mass numbers A ≳ 88, we demonstrate that [Te iii] $2.10\, \rm \mu m$ is indeed expected to be the strongest emission line in the near infrared region. We estimate that the required mass of Te iii is ∼10−3 M⊙, corresponding to the merger ejecta of 0.05 M⊙, which is in agreement with the mass estimated from the kilonova light curve.
A cautionary lesson from Gaia systematics: the mono-metallic globular cluster NGC 5904
Authors: Bianchini Paolo , Mastrobuono-Battisti Alessandra 
Published: September 2023

ABSTRACT
The study of the chemistry of the stellar populations in globular clusters (GCs) is a fundamental task to unveil their formation in the high-redshift universe and to reconstruct the build-up of our Galaxy. Using metallicity estimates from BP/RP low-resolution Gaia DR3 spectra, a recent work presented the surprizing detection of two stellar populations with distinct metallicities in the stellar stream of the GC NGC 5904, otherwise considered a mono-metallic system. The presence of these two populations, with [Fe/H] ∼ −1.4 and [Fe/H] ∼ −2.0 dex, was taken as the evidence of a merger origin of the cluster. In this Letter, using the same data set complemented by new robust metallicity estimates, we carry out a detailed analysis of the metallicity distribution of stars belonging both to the cluster and to its stellar stream, explicitly focusing on the subtle effects of data systematics. We demonstrate that the population at [Fe/H] ∼ −2.0 dex is a data artefact due to error systematics, affecting especially faint stars. The new higher quality metallicity sample corroborates this finding, and it indicates the presence of only one population of stars with metallicity of [Fe/H] ∼ −1.3 dex, in agreement with previous literature studies. We, therefore, conclude that both NGC 5904 and its stellar stream are mono-metallic systems, and emphasize the need of carefully examining systematic effects in large and complex data.
Unmodificated stepless regulation of CRISPR/Cas12a multi-performance
Authors: Zhao Rong , Luo Wang , Wu You , Zhang Li , Liu Xin , Li Junjie , Yang Yujun , Wang Li , Wang Luojia , Han Xiaole , Wang Zhongzhong , Zhang Jianhong , Lv Ke , Chen Tingmei , Xie Guoming 
Published: September 2023

Abstract
As CRISPR technology is promoted to more fine-divided molecular biology applications, its inherent performance finds it increasingly difficult to cope with diverse needs in these different fields, and how to more accurately control the performance has become a key issue to develop CRISPR technology to a new stage. Herein, we propose a CRISPR/Cas12a regulation strategy based on the powerful programmability of nucleic acid nanotechnology. Unlike previous difficult and rigid regulation of core components Cas nuclease and crRNA, only a simple switch of different external RNA accessories is required to change the reaction kinetics or thermodynamics, thereby finely and almost steplessly regulating multi-performance of CRISPR/Cas12a including activity, speed, specificity, compatibility, programmability and sensitivity. In particular, the significantly improved specificity is expected to mark advance the accuracy of molecular detection and the safety of gene editing. In addition, this strategy was applied to regulate the delayed activation of Cas12a, overcoming the compatibility problem of the one-pot assay without any physical separation or external stimulation, and demonstrating great potential for fine-grained control of CRISPR. This simple but powerful CRISPR regulation strategy without any component modification has pioneering flexibility and versatility, and will unlock the potential for deeper applications of CRISPR technology in many finely divided fields.
A suspected case of Lyme disease causing complete heart block
Authors: Isha Shahin , Sharma Rohan , Hannon Rachel M , Sanghavi Devang K 
Published: September 2023

Abstract
Carditis is a rare complication of Lyme disease and usually presents in the early dissemination phase, several weeks after exposure to a tick bite. Conduction abnormalities are the most common manifestation of Lyme carditis. The presentation can vary from atrioventricular conduction delay (first-degree atrioventricular conduction block) to life-threatening situations, such as a complete heart block. Although such manifestations occur late, our case report describes an interesting case where the patient developed a complete heart block in the setting of acute Lyme disease. An elevated IgM with negative IgG Lyme serology titer, an unusual finding, initially led us to face a diagnostic dilemma. Our suspicion of a tick bite was affirmed when we detected a positive titer for Babesia microti, an organism carried by the same tick and a common co-infection with Lyme disease. The patient improved with antibiotic therapy and temporary pacemaker support during the initial few days of admission.
Carotidynia presenting as an atypical cause of unilateral neck pain in the emergency department
Authors: Baig Muhammad Akbar , Asad Sadia 
Published: September 2023

Abstract
Carotidynia is a rare presentation of atypical neck and face pain, which is due to inflammation around the carotid artery. Symptoms can get aggravated by head and neck movements, jaw movements and deglutition. It is usually a self- limiting illness, and it is treated conservatively with analgesics. Because of it is rarity, and partly due to physician’s lack of understanding, it remains underdiagnosed. Our case report aims to shed light on the importance of how its diagnosis cannot be missed.
Treatment of pediatric antimuscarinic delirium with oral rivastigmine
Authors: Yakey Brandtly , Vohra Varun , Martin Amarilis , King Andrew M 
Published: September 2023

Abstract
Antimuscarinic drug toxicity is a common pediatric emergency, which produces central and peripheral symptoms. Treatment of agitation and hyperactive antimuscarinic delirium, with first-line agents like cholinesterase inhibitors or benzodiazepines, is imperative to prevent severe toxicity. Intravenous physostigmine salicylate is a cholinesterase inhibitor that is commonly used to treat central antimuscarinic delirium. Its chemical structure facilitates crossing of the blood–brain barrier. Overlapping nationwide physostigmine and benzodiazepine shortages have prompted consideration of therapeutic alternatives. Rivastigmine is a long-acting cholinesterase inhibitor with a similar chemical structure to physostigmine. It represents a potential therapeutic option for antimuscarinic delirium. Rivastigmine offers potential benefits over physostigmine including a longer duration of action, slower rate of central nervous system penetration, more favorable side effect profile, and availability in multiple formulations. A paucity of literature exists describing the use of rivastigmine for central antimuscarinic delirium. We describe the effective use of oral rivastigmine in a child with central antimuscarinic delirium.
Development and External Validation of Individualized Prediction Models for Pain Intensity Outcomes in Patients With Neck Pain, Low Back Pain, or Both in Primary Care Settings
Authors: Archer Lucinda , Snell Kym I E , Stynes Siobhán , Axén Iben , Dunn Kate M , Foster Nadine E , Wynne-Jones Gwenllian , van der Windt Daniëlle A , Hill Jonathan C 
Published: September 2023

Abstract

Objective
The purpose of this study was to develop and externally validate multivariable prediction models for future pain intensity outcomes to inform targeted interventions for patients with neck or low back pain in primary care settings.

Methods
Model development data were obtained from a group of 679 adults with neck or low back pain who consulted a participating United Kingdom general practice. Predictors included self-report items regarding pain severity and impact from the STarT MSK Tool. Pain intensity at 2 and 6 months was modeled separately for continuous and dichotomized outcomes using linear and logistic regression, respectively. External validation of all models was conducted in a separate group of 586 patients recruited from a similar population with patients’ predictor information collected both at point of consultation and 2 to 4 weeks later using self-report questionnaires. Calibration and discrimination of the models were assessed separately using STarT MSK Tool data from both time points to assess differences in predictive performance.

Results
Pain intensity and patients reporting their condition would last a long time contributed most to predictions of future pain intensity conditional on other variables. On external validation, models were reasonably well calibrated on average when using tool measurements taken 2 to 4 weeks after consultation (calibration slope = 0.848 [95% CI = 0.767 to 0.928] for 2-month pain intensity score), but performance was poor using point-of-consultation tool data (calibration slope for 2-month pain intensity score of 0.650 [95% CI = 0.549 to 0.750]).

Conclusion
Model predictive accuracy was good when predictors were measured 2 to 4 weeks after primary care consultation, but poor when measured at the point of consultation. Future research will explore whether additional, nonmodifiable predictors improve point-of-consultation predictive performance.

Impact
External validation demonstrated that these individualized prediction models were not sufficiently accurate to recommend their use in clinical practice. Further research is required to improve performance through inclusion of additional nonmodifiable risk factors.
Utility of the capabilities, opportunities, motivations model for understanding changes in behavior
Authors: Armitage Christopher J , Keyworth Chris , Gartland Nicola , Coleman Anna , Fishwick David , Johnson Sheena , van Tongeren Martie 
Published: September 2023

Abstract

Background
Wearing face coverings to prevent airborne viral transmission has at times been legally mandated, followed by periods when rules were relaxed. The present study tracks changes in face covering and the impacts on people’s perceptions of their capabilities, opportunities and motivations.

Methods
Three-wave survey. At wave 1 (25 January–6 February 2022), 10 622 UK adults reported: (a) sociodemographic characteristics; (b) face covering in work, public transport and indoor leisure settings and (c) capabilities, opportunities and motivations. Measures were repeated 1–18 March 2022 and 20 May–6 June 2022. Data were analyzed descriptively, within-participants analysis of covariance (ANCOVA) and multiple linear regression.

Results
Face covering decreased over time as rules around the wearing of face coverings relaxed. Perceptions of capabilities, opportunities and motivations to wear face coverings were consistently associated with the actual wearing of face coverings, with marked decreases in motivations over time.

Conclusions
Decreases in motivations seem to explain best the reasons for declining levels of face covering. Further work is required to develop interventions to change people’s motivations and promote the wearing of face coverings, should they be required in the future.
Measuring Total Carbon Pricing
Authors: Agnolucci Paolo , Fischer Carolyn , Heine Dirk , Montes de Oca Leon Mariza , Pryor Joseph , Patroni Kathleen , Hallegatte Stéphane 
Published: September 2023

Abstract
While countries increasingly commit to pricing greenhouse gases directly through carbon taxes or emissions trading systems, indirect forms of carbon pricing—such as fuel excise taxes and fuel subsidy reforms—remain important factors affecting the mitigation incentives in an economy. Taken together, how can policy makers think about the overall price signal for carbon emissions and the incentive it creates? We develop a methodology for calculating a total carbon price applied to carbon emissions in a sector, a fuel, or the whole economy. We recognize that rarely is a single carbon price applied across an economy; many direct carbon pricing instruments target specific sectors or even fuels, much like indirect taxes on fossil fuels; and carbon and fuel taxes can be substituted for one another. Tracking progress on carbon pricing thus requires following both kinds of price interventions, their coverage, and specific exemptions. This inclusive total carbon pricing measure can facilitate progress in discussions on minimum carbon price commitments and inform assessments of the pricing of carbon embodied in traded goods. Calculations across 142 countries from 1991 to 2021 indicate that although direct carbon pricing now covers roughly one-quarter of global emissions, the global total carbon price is not that much higher than it was in 1994 when the United Nations Framework Convention on Climate Change entered into force. Indirect carbon pricing still comprises the lion's share of the global total carbon price, and it has stagnated. Taking these policy measures into account reveals that many developing countries—particularly net fuel importers—contribute substantially to global carbon pricing. Tackling fuel subsidy reform and pricing coal and natural gas emissions more fully would have a profound effect on aligning carbon prices across countries and sectors and with their climate costs.
Pathway to Independence Awards (K99/R00): Funding Dynamics and Prediction of Future National Institutes of Health Research Project Funding
Authors: Gillen Kelly M. , Markowitz Daniel M. , Long Patricia , Villegas-Estrada Adriel , Anglon Gabriela , Chang Eileen , Gupta Ajay 
Published: September 2023

Abstract

Purpose
The authors used the National Institutes of Health (NIH) RePORTER (Research Portfolio Online Reporting Tools) to evaluate funding trends and historic NIH investment increase in the K99 award pathway and examine whether R00 to R01 or R21 achievement time correlated with the future success of an early-stage NIH-funded investigator.

Method
All K99 awards and funding data in this study were limited to all clinical departments. The authors identified all researchers and awards through a K99 search from fiscal years (FYs) 2007 to 2022 across all clinical departments and investigated trends in K99 awards and funding from NIH FYs 2007 to 2022. They generated an R00 data set and analyzed the K99 to R00 achievement statistics from FYs 2007 to 2022. The authors aggregated NIH annual data files for FYs 2007 to 2021 to generate a master data file of all R01 and R21 awards. They linked R01 and R21 award data to the researcher previously identified through the K99 search and focused on the connection between K99/R00 awardees and subsequent R01 or R21 awards.

Results
From FY 2008 to FY 2022, the NIH K99 budget increased 127.0%, whereas the NIH program-level budget increased 17.3%. A principal investigator’s mean funding per year significantly decreased as time from R00 to R01 or R21 increased (P < .001); 7 of 15 comparisons differed significantly (2 at P < .01 and 5 at P < .001).

Conclusions
NIH investment in the K99 award pathway has substantially outpaced the NIH program-level budget increase, and there is a strong association between mean funding per year since the start of the R00 phase and time from R00 to R01 or R21. This analysis may be useful to clinical departments as they evaluate selecting new and retaining current biomedical scientists for independent research positions.
Evaluating the Health of the Work Environment and the Perception of New Nurses During the Transition to Practice in Critical Care
Authors: Gellner Paula , DiLibero Justin , Griffin Annette 
Published: September 2023

Background
New nurses are the major source of hiring for most hospitals. They fill vacancies left by seasoned nurses creating an experience-complexity gap. Turnover among new-graduate nurses is as high as 85% in the first 2 years.

Objectives
The purpose of this study was to provide a deeper understanding of the factors contributing to turnover. The specific aims were (1) to better understand novice nurses' perceptions of their transition to critical-care practice and (2) to describe all eligible critical-care nurses' perceptions of a healthy work environment.

Methods
A quantitative descriptive design was used. Data were collected over 3 weeks in February 2022 from novice nurses (n = 12) who completed the Casey-Fink Nurse Experience Survey and from novice and experienced nurses (n = 47) who completed the American Association of Critical-Care Nurses' Healthy Work Environment Assessment Tool. Data were analyzed using descriptive statistics.

Results
Respondents to the Casey-Fink Nurse Experience Survey (n = 12) indicated feeling well supported by family, friends, and preceptors, although they felt less positive about prioritizing care, organizing patient needs, and recommending changes to the plan of care. The overall mean score on the Health Work Environment Assessment Tool was 2.99 (n = 47), indicating the need for improvement. Responses varied by unit, years of experience, and certification status.

Conclusion
This study contributes to the evolving body of nursing knowledge and has provided a more detailed understanding of the health of the work environment and perceptions of new nurses during the transition to practice.
Grief Support and Coping Mechanism Mediate the Effect of Grief on Burnout Among Intensive Care Unit Nurses
Authors: Jit Singh Gurbinder Kaur , Low Wah Yun , Abdullah Khatijah Lim 
Published: September 2023

Background
Patients' death caused the intensive care unit (ICU) nurses to grieve, which led to their burnout. Intensive care unit nurses use various coping mechanisms and need support to overcome grief.

Objective
The aim of this study was to identify the mediation effects of coping mechanisms and grief support on the impact of grief on burnout.

Method
This cross-sectional study among 660 ICU nurses from 9 hospitals used 4 self-reported instruments to collect data, apart from the sociodemographic and employment-related variables. A final model was developed through structural equation modeling after establishing the construct validities of the measures through confirmatory factor analysis.

Results
The representation of ICU nurses from each hospital was greater than 50%, with the majority being female (90.8%) with a mean age of 27.27 years. Most nurses perceived the absence of grief, low burnout, and moderate to low grief support. The nurses use various coping mechanisms. Grief support significantly mediated the relationship between grief and burnout using a bootstrapping method with a mediation strength using the variance counted for (VAF) of 34.95%. The final model fit indices with acceptable values validated the direct and indirect relationships of grief, grief support, and coping mechanisms on burnout.

Discussion
The significant influence of grief support in mediating the effect of grief on burnout is an important finding. The nursing and hospital management can use this finding to provide grief support to ICU nurses, enhance the grief support resources, and promote future studies to test the model's validity and applicability to health care professionals who frequently face patients' death.