bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATG versus PTCy in matched unrelated donor haematopoietic stem cell transplantations with non‐myeloablative conditioning
Authors: Aydin Mesire , de Leeuw David C. , Rutten Caroline E. , Visser Otto J. , Tang Man Wai , van Roessel Cinthy , Janssen Jeroen J. W. , Biemond Bart J. , van de Loosdrecht Arjan A. , Hazenberg Mette D. , Meijer Ellen , Nur Erfan 
Published: August 2023

SummaryGraft‐versus‐host disease (GvHD) is a serious complication of allogeneic haematopoietic stem cell transplantation (HSCT). Both anti‐thymocyte globulin (ATG) and post‐transplant cyclophosphamide (PTCy) are used as lymphocyte‐depleting strategies, yet a systematic comparison of transplantation outcomes between these two methods in matched unrelated donors (MUD) transplantations with non‐myeloablative conditioning (NMC) is lacking. Adult patients with haematological malignancies who had undergone MUD HSCT with NMC regimens between 2014 and 2021 at 2 centres in Amsterdam (ATG: n = 95, PTCy: n = 90), were included in this retrospective study. Patient characteristics were comparable between the groups. The cumulative incidence of acute GvHD grade II–IV was 48% in the ATG group compared to 21% in the PTCy group (p < 0.001). The 3‐year moderate/severe chronic GvHD was similar in both groups (p = 0.69). While the relapse rate was comparable between the groups (ATG 31% vs. PTCy 34%, p = 0.94), non‐relapse mortality tended to be higher in the ATG group (17% vs. 9%, p = 0.069). Overall survival was similar in both groups (p = 0.12). In conclusion, PTCy‐based regimens resulted in a significantly lower rate of acute GvHD than ATG‐containing regimens in MUD transplantations with NMC. Whether PTCy results in improved overall survival as compared to ATG needs to be elucidated in larger prospective studies.
A novel tension relief technique to aid the primary closure of traumatic equine wounds under excessive tension
Authors: Comino Francesco , Pollock Patrick J. , Fulton Ian , Hewitt‐Dedman Charlotte , Handel Ian , Gorvy Dylan A. 
Published: August 2023

AbstractBackgroundTo achieve an excellent functional and cosmetic result, primary closure is preferred over leaving wounds to heal by secondary intention. However, traumatic wounds are often under excessive tension during wound closure and incorrect suture technique can compromise microcirculation, leading to skin necrosis and impaired wound healing.ObjectiveTo describe an inexpensive and effective tension relief technique that helps the successful primary closure of a variety of equine wounds at high risk of dehiscence.Study designRetrospective case series.MethodsAll wounds that were managed with the Tension Tile System (TTS) at four Equine Hospitals between March 2017 and May 2021 were evaluated. The wounds were classified according to various criteria including anatomical location, time elapsed prior to surgery, depth of wound and post‐surgical use of immobilisation. Outcome criteria were based on the success of primary intention healing. The duration of convalescence (weeks) after surgery was also recorded.ResultsDuring the study period, the TTS was used in 191/860 (22%) wounds repaired under general anaesthesia or standing sedation. Overall, primary intention healing (Group A) was achieved in 132 of 191 cases (69%, CI 62%–75%), with partial dehiscence (Group B) in a further 30/191 cases (16%, CI 11%–22%). Severe dehiscence (Group C) was recorded in 29/191 cases (15%, CI 11%–21%). The median convalescence time was 4 weeks (Range 3–15, interquartile range 4–6) in Group A.Main limitationsRetrospective nature of the study and subjective outcome assessment. The technique was applied to wounds under significant tension; however, this was based on a subjective assessment by the surgeons involved.ConclusionsThe Tension Tile System is an economical and effective technique for challenging equine wounds under tension, in a variety of anatomical locations.
Empirical modeling of stress concentration factors using finite element analysis and artificial neural networks for the fatigue design of tubular KT‐joints under combined loading
Authors: Iqbal Mohsin , Karuppanan Saravanan , Perumal Veeradasan , Ovinis Mark , Nouman Hina 
Published: August 2023

AbstractThe hotspot stress (HSS) approach for the fatigue design of tubular joints requires that peak HSS be known. Peak HSS in tubular joints is usually determined based on the stress concentration factor (SCF) estimated from empirical models developed through extensive experimental investigations and finite element analysis. While peak HSS usually occurs at a KT‐joint's crown and saddle points, its location may change if the tubular joint is subjected to a combination of axial, in‐plane bending, or out‐of‐plane bending loads. This study investigated the peak HSS and its location in a typical KT‐joint subjected to the combined loading. Specifically, empirical models to determine the SCF around the brace axis have been developed using extensive finite element analysis and artificial neural networks (ANN) simulations. Less than 3% error was noticed between peak HSS determined through developed models and FEA. Hence, the ANN‐based SCF equations and principle of superposition can be used to calculate peak HSS rapidly for fatigue design of tubular joints. This methodology is applicable for developing empirical models for SCF in other tubular joints and boundary conditions.
Machine learning methods to predict the fatigue life of selectively laser melted Ti6Al4V components
Authors: Centola Alessio , Ciampaglia Alberto , Tridello Andrea , Paolino Davide Salvatore 
Published: August 2023

AbstractThe aim of the present paper is to predict the fatigue life of Selectively Laser Melted (SLMed) Ti6Al4V components via the process parameters, the thermal treatments, the surface treatments and the stress amplitude, adopting machine learning techniques to reduce the cost of further fatigue testing, and to deliver better predictive fatigue designs. The studies resulted in reliable algorithms capable of predicting trustful fatigue curves. The methods have been trained with experimental data available in the literature and validated on testing sets to assess the extrapolation limits and to compare the different methods. The behavior of the networks has also been mapped by varying one SLM process parameter at the time, highlighting how each one affects the life.
Composition‐dependent thermal and thermomechanical properties of spinel‐type MgAlON from density functional calculation
Authors: Ren Lu , Wang Hao , Tu Bingtian , Xu Pengyu , Wang Weimin , Fu Zhengyi 
Published: August 2023

AbstractAs ceramics based on magnesium aluminum oxynitrides solid solutions are promising materials as refractories, windows/armors, phosphors, and so forth, it is essential to explore their thermal and thermomechanical properties, owing to the physical requirements on application. In this study, Mg5xAl23−5xO27+5xN5−5x were chosen for the investigation on composition‐dependent thermal and thermomechanical properties by the theoretical calculations. Though the binary system with octahedral bonds contributes more to the thermal expansion coefficient of Mg5xAl23−5xO27+5xN5−5x, the binary system with tetrahedral bonds plays an important role in the variation of the thermal expansion coefficient. The change of heat capacity with the rise of x is mainly attributed to the variation of covalent character of Mg5xAl23−5xO27+5xN5−5x. Moreover, the thermal conductivity is mainly affected by the scattering from atoms in 8a sites. Both thermal and mechanical properties contribute to the variation of thermomechanical properties of Mg5xAl23−5xO27+5xN5−5x. This study can provide guidance to designing spinel materials with desirable thermal and thermomechanical properties for application.
Local and high‐strength joining of transparent glass and glass‐ceramics by femtosecond Bessel beam
Authors: Fedotov Sergey , Lipateva Tatiana , Lipatiev Alexey , Dymshits Olga , Lotarev Sergey , Sigaev Vladimir 
Published: August 2023

AbstractThe creation of robust joint among different materials with notably different coefficients of thermal expansion (CTE) is an urgent task for the development of the engineering, laser technology, and aerospace industry. In this regard, femtosecond laser welding is a promising technique for efficient adhesion‐free bonding of transparent materials. This paper reports on the laser welding of laser phosphate glass (CTE = 110 × 10−7 K−1) and spinel‐based glass–ceramic (CTE = 50 × 10−7 K−1) by the Bessel beam. Dependencies of weld geometric parameters on the pulse energy and scanning speed were investigated, and the laser exposure conditions were optimized for durable welding. The weld joints were tested on shear strength, which was shown to be as record high as up to 147 MPa. Atomic force microscopy, Raman spectroscopy, and elemental analysis were used to investigate the structure and morphology of the weld after its fracture, which revealed the laser‐induced amorphization of glass–ceramics and the formation of strong interconnection by laser‐driven mutual diffusion of two glassy phases. The results demonstrate the prospects for using femtosecond lasers for efficient industrial welding of a wide range of materials.
In too deep? A systematic literature review of fully‐immersive virtual reality and cybersickness among older adults
Authors: Drazich Brittany F. , McPherson Rachel , Gorman Emily F. , Chan Thomas , Teleb Jejomar , Galik Elizabeth , Resnick Barbara 
Published: August 2023

AbstractBackgroundVirtual reality technology holds great promise in improving the health and well‐being of older adults; however, this technology is associated with potential risks that may outweigh the benefits. The purpose of this systematic review is to synthesize and critique the existing literature on fully‐immersive virtual reality interventions for older adults and the associated risk of cybersickness.MethodsWe searched eight databases for studies that utilized fully‐immersive virtual reality, stated the population as older adults, provided outcomes related to cybersickness, and were written or translated into the English language. Our search generated 332 articles, 39 of which were selected for inclusion in this systematic synthesis and appraisal.ResultsWe found that the majority of studies utilized a one‐time session. The studies generally had weak sample generalizability and methodological design, but strong data collection and participant retention. The studies nearly all used the Simulator Sickness Questionnaire to measure cybersickness, but the scoring for the Simulator Sickness Questionnaire varied or was not mentioned. Most included studies reported only minor cybersickness among older adult participants.ConclusionResearchers might conclude that the benefits of virtual reality interventions outweigh the risk of cybersickness in this population. Going forward, researchers should concentrate on the efficacy of virtual reality interventions among older adults, using larger samples and randomized controlled study design, along with measuring dosage effects.
One‐year outcomes of deep brain stimulation in refractory Tourette syndrome
Authors: Lee Junghan , Chang Kyung Won , Jung Hyun Ho , Kim Dre , Chang Jin Woo , Song Dong‐Ho 
Published: August 2023

AimDeep brain stimulation (DBS) is one option for treating refractory Tourette syndrome (TS); however, it remains unclear which preoperative factors are predictive of DBS outcomes. This study investigated the efficacy of DBS targeting the anteromedial globus pallidus internus and evaluated predisposing factors affecting the outcomes of DBS in a single center in Korea.MethodTwenty patients who had undergone DBS for refractory TS were reviewed retrospectively. Tic symptoms were followed up at 3‐month intervals for up to 1 year after surgery. The Yale Global Tic Severity Scale was used to evaluate preoperative/postoperative tic symptoms. Scores from the Yale‐Brown Obsessive Compulsive Scale, Beck Depression Inventory‐II, and Beck Anxiety Inventory were also evaluated.ResultsPatients with refractory TS achieved improvement in tic symptoms within 1 year after DBS. Initial responders who achieved a 35% reduction in Yale Global Tic Severity Scale total score within the first 3 months after DBS showed larger treatment effects during 1‐year follow‐up. Although no clinical or demographic factors were predictive of initial responses, patients with serious self‐injurious behaviors tended to show delayed responses.ConclusionThis is the first study to our knowledge to report the DBS outcomes of 20 patients with TS in a single center in Asia. Our study supports the efficacy of DBS targeting anteromedial globus pallidus internus in refractory TS with no evident serious adverse events. Initial responses after DBS seem to be a predictor of long‐term outcomes after surgery.
Gender differences in the association between physical frailty and life satisfaction among older adults in India
Authors: Pai Manacy , Muhammad T. , Das Sayani , Chaudhary Mamta , Srivastava Shobhit 
Published: August 2023

BackgroundOne of the sustainable development goals' (SDGs) primary goals (Goal 3) is to ensure healthy lives and promote well‐being for persons of all ages. While extensive literature documents the link between physical frailty and low life satisfaction (LLS) among older adults, research of this nature is limited within low and middle‐income countries including India. The purpose of this study was to examine the association between physical frailty and life satisfaction among community‐dwelling older men and women in India.MethodsData come from the 2017–18 wave 1 of the Longitudinal Ageing Study in India (LASI), with a sample of 30 390 individuals aged 60 and above (14 559 men and 15 831 women). Physical frailty was assessed using an adapted version of the frailty phenotype developed by Fried and colleagues. Ordered logistic regression models are employed to examine the association between physical frailty and life satisfaction.ResultsThe prevalence of frailty was higher in older women than men (32.2% vs. 27.5%). Nearly 30.4% of men and 33.8% of women reported having LLS. However, after adjusting for the selected confounders, women were less likely (adjusted odds ratio [aOR]: 0.92; CI: 0.87–0.97) to report LLS compared to men. The physically frail older adults were more likely (aOR: 1.40; CI: 1.27–1.55) to report LLS relative to their physically stronger counterparts. Moreover, we found that frail older men had higher odds of reporting LLS than non‐frail older men (aOR: 1.25; CI: 1.09–1.43). Also, non‐frail older women had lower odds of reporting LLS than non‐frail older men (aOR: 0.80; CI: 0.67–0.95).ConclusionsFindings of our study suggest that policies and programs to address later life well‐being need to consider gender differences. Doing so would not only help identify older adults most at risk of LLS, but gender differentiated policies would help streamline health expenditures and costs typically relegated to assist all older adults without proper focus on the uniqueness of their social location.
Enamel renal syndrome: A case report with calcifications in pulp, gingivae, dental follicle and kidneys
Authors: Khalifa Rabeb , Kammoun Rym , Mansour Lamia , Ben Alaya Touhami , Ghoul Sonia 
Published: August 2023

AbstractBackgroundEnamel renal syndrome is a rare genetic disorder transmitted through an autosomal recessive mode. It is featured by a hypoplastic amelogenesis imperfecta, delayed tooth eruption, gingival fibromatosis, and nephrocalcinosis. The aim of this study was to describe clinically, radiologically, and histologically the main features of enamel renal syndrome and to point out the role of dentists in early diagnosing this genetic disease.Materials and methodsOur case of enamel renal syndrome was initially described by clinical, radiographic, and genealogic data, then complemented by ultrasound examination of the kidneys and microscopic observation of gingivae.ResultsThe study showed the presence of amelogenesis imperfecta (AI), several teeth impaction, gingival hyperplasia, bilateral nephrocalcinosis, and multiple calcifications in pulp, gingiva, dental follicle, and kidneys.ConclusionThe patient was followed for a full mouth rehabilitation and also referred to a nephrology for global medical checkup. The dentist plays a key role in diagnosing genetic diseases and in referring patients for medical comprehensive care.
Spatial heterogeneity of soil organic carbon and soil nutrients and their controlling factors in a small watershed in Northeast China
Authors: Lixin Wang , Zhuoxin Chen , Mingming Guo , Shaoliang Zhang , Xingyi Zhang , Pengchong Zhou , Jinzhong Xu , Xin Liu , Jiarui Qi , Zhaokai Wan 
Published: August 2023

AbstractUnderstanding the spatial distribution of soil organic carbon (SOC) and soil nutrients is crucial for optimizing land management in watersheds. This study explored the spatial distribution of SOC, total nitrogen (TN) and total phosphorus (TP) in topsoil (0–20 cm) at a hilly small watershed site in Northeast China, and identified the controlling factors. The Gaussian mixture model optimally described SOC and TN with the ratio of nugget to sill variance (C0/[C + C0]) indicating moderate spatial dependence for SOC (63.7%) and TN (59.3%). TP was best modelled by the spherical model and demonstrated weak spatial autocorrelation and strong human influence, with a nugget to sill variance of 0.841. Land use significantly affected SOC, TN and TP contents, with the highest values recorded in woodland, followed by farmland and shrubland. Soil properties including bulk density (BD), gravel content (GC), moisture content (MC), soil porosity (SP) and the mean weight diameter (MWD) of water‐stable aggregates significantly correlated with SOC and TN content, but not with TP. Redundancy analysis revealed that soil properties (BD, GC and SP), topography (slope and aspect) and gully erosion contributed 55.7%, 24.7% and 4.3% of the spatial variation in SOC, TN and TP, respectively. Hence, these are the dominant factors shaping the spatial variation of SOC and soil nutrients at the site. These results can aid the further development of optimized land management strategies.
Comparison of 4 point‐of‐care techniques to detect correct positioning of nasogastric tubes in dogs (2020–2021)
Authors: Ramesh Meera , Brooks Aimee C , Thomovsky Elizabeth , Johnson Paula , Fulkerson Carrie , Parnell Nollie , Weng Hsin‐Yi 
Published: August 2023

AbstractObjectiveTo compare 4 point‐of‐care (POC) techniques to assess nasogastric (NG) tube placement versus radiographs as a reference standard. POC methods included air inflation with auscultation, fluid aspiration with pH measurement, ultrasonography, and capnography.DesignProspective observational study in hospitalized dogs between 2020 and 2021.SettingUniversity teaching hospital.AnimalsFifty‐one dogs requiring NG tube placement as part of their normal care.InterventionsAfter standard blind NG tube placement, each POC method was performed following standardized instructions. All POC methods were scored as to whether the investigator believed the tube to be in the gastrointestinal tract (as indicated by positive auscultation of borborygmus during insufflation, positive fluid aspiration with pH ≤5, presence of hyperechoic shadow in the esophagus, or absence of capnographic waveform). Subsequently, radiographs were taken to determine NG tube position as a gold standard. The sensitivity, specificity, and accuracy of each test as compared to 2‐view thoracic radiographs were determined.Measurements and Main ResultsSensitivity, specificity, and accuracy for each POC technique were as follows: air auscultation (84.4%, 50.5%, and 80.4%, respectively), neck ultrasound (95.6%, 83.3%, and 94.1%, respectively), capnography (91.1%, 33.3%, and 84.3%, respectively), and fluid aspiration with pH measurement (22.2%, 100%, and 31.4%, respectively).ConclusionsAmong the 4 techniques evaluated, neck ultrasound had the best overall performance for assessing NG tube placement. Fluid aspiration with pH measurement might also have potential due to perfect specificity, but its clinical utility may be limited by low sensitivity and accuracy. Nonetheless, 2‐view thoracic radiography should still be considered the standard method for confirmation of NG tube placement as none of the 4 POC techniques investigated showed both high sensitivity and perfect specificity.
Retrospective evaluation of the incidence of presumed feline urethral obstruction during a prepandemic year compared to a pandemic year
Authors: Kerley Jessica B. , Tart Kelly M. , Rendahl Aaron , Powell Lisa L. 
Published: August 2023

AbstractObjectiveTo investigate the influence of the coronavirus disease 2019 (COVID‐19) pandemic on the incidence of urethral obstruction (UO) in male cats.DesignRetrospective study.SettingOne veterinary university teaching hospital and 6 private practice veterinary specialty and emergency centers.AnimalsA total of 24,937 total feline cases presenting to the emergency room (ER) between March 2019 and March 2021.Measurements and Main ResultsOut of 24,937 total cases, 1793 male cats met the inclusion criteria for diagnosis of UO. Of those, 327 cases were identified in which an additional diagnosis of either urolithiasis or neoplasia was made and were therefore excluded. The remaining 1466 UO cases were presumed to be idiopathic urethral obstruction (iUO) caused by feline interstitial cystitis (FIC) alone. Of those, 637 cats presented during the prepandemic year and 829 cats presented during the pandemic year.Key FindingsIncidence of presumptive iUO increased by 30% during the COVID‐19 pandemic. Total feline emergency caseload increased by 38%. iUO accounted for 6.08% and 5.73% of total feline emergency cases during the prepandemic and pandemic years, respectively.Clinical SignificanceThe reported increase in incidence of feline UO is likely due to the increase in overall emergency feline caseload.
Las medidas cautelares en el derecho de la competencia: desarrollo en Colombia 1992-2022
Authors: Londoño de Vivero Daniel Eduardo 
Published: August 2023

El derecho de la competencia busca la protección del libre mercado a través del establecimiento de normas que garanticen la libre competencia económica. Dentro de las herramientas con las que cuentan las autoridades de competencia en el mundo se encuentran los procesos administrativos sancionatorios en los que estas pueden decretar medidas cautelares con el propósito de realizar una intervención a priori para interrumpir la ejecución de conductas anticompetitivas.
El objetivo del presente artículo es definir y caracterizar las medidas cautelares en materia de competencia, partiendo de la revisión de su regulación legal en la Unión Europea, España, Francia y México, para luego focalizar el análisis en el desarrollo de estas en Colombia, desde su introducción en 1992 hasta 2022. Lo anterior, por medio del examen del régimen legal vigente y el estudio de los cinco casos en que la Superintendencia de Industria y Comercio ha decretado medidas cautelares en procesos de prácticas restrictivas de la competencia. Finalmente, se presentarán algunos retos que, a nivel normativo, deben ser revisados por el Congreso de la República.