bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorinated Solvent‐Coupled Anion‐Derived Interphase to Stabilize Silicon Microparticle Anodes for High‐Energy‐Density Batteries
Authors: Liu Yan , Huang Yutong , Xu Xin , Liu Yang , Yang Jianghong , Lai Jiawei , Shi Junkai , Wang Shuxian , Fan Weizhen , Cai Yue‐Peng , Lan Ya‐Qian , Zheng Qifeng 
Published: May 2023

AbstractSi microparticle (SiMP) anodes feature much lower production cost and higher tap density compared to their nanosized counterparts, which hold great promise for high‐energy‐density lithium‐ion batteries, yet they suffer from unavoidable particle pulverization during repeated cycling, thus making their practical application extremely challenging. Herein, a non‐flammable localized high‐concentration electrolyte (LHCE) is rationally formulated using a fluorinated solvent, 2,2,2‐trifluoroethyl methyl carbonate (FEMC), to induce fluorinated solvent‐coupled anion‐derived interfacial chemistry. Unlike other LHCEs, the FEMC‐based LHCE is demonstrated to build a highly robust and stable F‐rich inorganic–organic bilayer solid–electrolyte interphase on SiMP anode, which endows stable cycling of SiMP anode (≈3.4 mAh cm−2) with an ultrahigh Coulombic efficiency of ≈99.7%. Coupled with its high anodic stability, the FEMC‐based LHCE endows unprecedented cycling stability for high‐energy‐density batteries containing high‐capacity SiMP anodes with Ni‐rich LiNi8Mn1Co1O2 or 5 V‐class LiNi0.5Mn1.5O4 cathodes. Remarkably, a 1.0 Ah‐level SiMP||LiNi8Mn1Co1O2 pouch‐cell stably operates for more than 200 cycles, representing the pioneering report in pouch cells containing SiMP anodes.
Enhancing the Cytocompatibility of Cobalt‐Iron Ferrite Nanoparticles Through Chemical Substitution and Surface Modification
Authors: Flores Urquizo Israel Alejandro , Máynez Tozcano Dayana Irais , Valencia Gómez Laura Elizabeth , Roacho Pérez Jorge Alberto , Chapa González Christian 
Published: May 2023

AbstractDue to their potential in numerous interdisciplinary fields, such as drug delivery, hyperthermia, and magnetic resonance imaging, magnetic nanoparticles have attracted widespread attention. In this study, cobalt ferrite nanoparticles are synthesized with varying amounts of iron and cobalt ions, and their cytocompatibility is evaluated before and after surface modification with amino‐silane (AEPTMS). Characterization of the synthesized nanoparticles is performed using scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, X‐ray diffraction, and Fourier transform infrared spectroscopy. In addition, it is observed that a slight reduction in the saturation magnetization of the coated materials. The cytotoxicity of these materials is evaluated using the MTT assay on fibroblast cells. This study focuses on the importance of the interface between the surface of magnetic nanoparticles, their coating, and their interaction with cells. This study presents an innovative approach to enhancing the cytocompatibility of cobalt ferrite nanoparticles through chemical substitution and surface modification with AEPTMS. The key findings demonstrate that the iron and cobalt ion ratio significantly impacts cytotoxicity, with the AEPTMS coating found to increase cell viability. These findings demonstrate the potential of these materials for biomedical applications, highlighting the importance of both the composition and surface coating of magnetic nanoparticles for biomedical applications.
Room Temperature Wearable Gas Sensors for Fabrication and Applications
Authors: Xiao Yanan , Li He , Wang Chen , Pan Si , He Junming , Liu Ao , Wang Jing , Sun Peng , Liu Fangmeng , Lu Geyu 
Published: May 2023

AbstractThe recent surge in demand for human–machine interaction (HMI), Internet of Things (IoTs), and artificial intelligence (AI) has created both opportunities and challenges for room‐temperature wearable gas sensors. These sensors serve as a source of perceptual information and can be easily integrated into wearable electronic devices due to their portability and miniaturization. In recent years, various types of wearable room temperature gas sensors have been developed for fields like environmental monitoring, healthcare, smart home, industrial security, food safety monitoring, and public security. These sensors not only adjust to the movements of human effortlessly but also have reduced power consumption. Therefore, room temperature wearable gas sensors hold great promise for the development of integrated intelligent gas sensing system worn on the human body. These sensors can be fabricated using various sensing materials to detect diverse target gases. This review provides a comprehensive summary of the preparation of sensing materials with extraordinary sensing capabilities at room temperature. Additionally, the article includes a brief discussion of the sensing mechanism, employing four models to explain it: oxygen adsorption, direct electron transfer, proton transfer, and ions conduction. Finally, this article discusses the various applications and future perspectives of room‐temperature wearable gas sensors.
Sustained inhibition of complement C1s with sutimlimab over 2 years in patients with cold agglutinin disease
Authors: Röth Alexander , Barcellini Wilma , D'Sa Shirley , Miyakawa Yoshitaka , Broome Catherine M. , Michel Marc , Kuter David J. , Jilma Bernd , Tvedt Tor Henrik Anderson , Weitz Ilene C. , Yoo Ronnie , Jayawardene Deepthi , Vagge Deepthi S. , Kralova Katarina , Shafer Frank , Wardȩcki Marek , Lee Michelle , Berentsen Sigbjørn 
Published: May 2023

AbstractCold agglutinin disease (CAD) is a rare, autoimmune, classical complement pathway (CP)‐mediated hemolytic anemia. Sutimlimab selectively inhibits C1s of the C1 complex, preventing CP activation while leaving the alternative and lectin pathways intact. In Part A (26 weeks) of the open‐label, single‐arm, Phase 3 CARDINAL study in patients with CAD and a recent history of transfusion, sutimlimab demonstrated rapid effects on hemolysis and anemia. Results of the CARDINAL study Part B (2‐year extension) study, described herein, demonstrated that sutimlimab sustains improvements in hemolysis, anemia, and quality of life over a median of 144 weeks of treatment. Mean last‐available on‐treatment values in Part B were improved from baseline for hemoglobin (12.2 g/dL on‐treatment versus 8.6 g/dL at baseline), bilirubin (16.5 μmol/L on‐treatment versus 52.1 μmol/L at baseline), and FACIT‐Fatigue scores (40.5 on‐treatment versus 32.4 at baseline). In the 9‐week follow‐up period after sutimlimab cessation, CP inhibition was reversed, and hemolytic markers and fatigue scores approached pre‐sutimlimab values. Overall, sutimlimab was generally well tolerated in Part B. All 22 patients experienced ≥1 treatment‐emergent adverse event (TEAE); 12 (54.5%) patients experienced ≥1 serious TEAE, including seven (31.8%) with ≥1 serious infection. Three patients discontinued due to a TEAE. No patients developed systemic lupus erythematosus or meningococcal infections. After cessation of sutimlimab, most patients reported adverse events consistent with recurrence of CAD. In conclusion, the CARDINAL 2‐year results provide evidence of sustained sutimlimab effects for CAD management, but that disease activity reoccurs after treatment cessation. NCT03347396. Registered November 20, 2017.
Recent Progress on Electrode Design for Efficient Electrochemical Valorisation of CO2, O2, and N2
Authors: Lin Zeheng , Han Chen , O'Connell George E. P. , Lu Xunyu 
Published: May 2023

AbstractCO2 reduction, two‐electron O2 reduction, and N2 reduction are sustainable technologies to valorise common molecules. Their further development requires working electrode design to promote the multistep electrochemical processes from gas reactants to value‐added products at the device level. This review proposes critical features of a desirable electrode based on the fundamental electrochemical processes and the development of scalable devices. A detailed discussion is made to approach such a desirable electrode, addressing the recent progress on critical electrode components, assembly strategies, and reaction interface engineering. Further, we highlight the electrode design tailored to reaction properties (e.g., its thermodynamics and kinetics) for performance optimisation. Finally, the opportunities and remaining challenges are presented, providing a framework for rational electrode design to push these gas reduction reactions towards an improved technology readiness level (TRL).
Old fossil findings in the Upper Triassic rocks of southern Brazil improve diversity of traversodontid cynodonts (Therapsida, Cynodontia)
Authors: Schmitt Maurício Rodrigo , Martinelli Agustín Guillermo , Kaiuca João Felipe Leal , Schultz Cesar Leandro , Soares Marina Bento 
Published: May 2023

AbstractIn this contribution we describe a new genus and species of gomphodontosuchine cynodont from the Late Triassic Hyperodapedon Assemblage Zone (AZ) of the Santa Maria Supersequence of southern Brazil, based on material collected 20 years ago. The new taxon, Santagnathus mariensis gen. et sp. nov., is based on numerous cranial and postcranial remains, which altogether provide data on several parts of the skeleton. Santagnathus mariensis is closely related to Siriusgnathus niemeyerorum and Exaeretodon spp. and expands the knowledge about gomphodontosuchine cynodonts. Morphologically, the new species has a skull bauplan particularly similar to S. niemeyerorum and E. riograndensis, differing from them by a unique combination of traits such as three upper incisors, the absence of a descending process in the jugal, a more posterior position of the postorbital bar and a preorbital region larger than the temporal one. The new traversodontid was found associated with the rhynchosaur Hyperodapedon sp., corroborating the assignment of the cynodont fossils to the Hyperodapedon AZ. We also provide comments on the status of the Argentine traversodontid cynodont Proexaeretodon vincei, typically considered a junior synonym of Exaeretodon argentinus, and here accepted as a valid taxon.
Balanced truncation reduced models of quadratic‐bilinear systems in time interval
Authors: Zhang Guoyun , Jiang Yao‐Lin , Xu Kangli 
Published: May 2023

AbstractAccumulative error along with time impedes the application of many computational methods on high‐precision simulation; therefore, time‐interval methods emerge. In this paper, a new model reduction method of quadratic‐bilinear (QB) systems based on time‐interval Gramians (TIGs) is presented. The conditions for generalized Lyapunov equations whose solutions are exactly TIGs to be solvable are derived. Lyapunov stability and error bound are discussed to demonstrate the succession and advance of time‐interval balanced truncation (TIBT). The accuracy and robustness are improved, as is illustrated in numerical results.
Einfluss des Wassergehalts auf die Druckfestigkeit von Beton unter hohen Dehnraten
Authors: Mosig Oliver , Beckmann Birgit , Curbach Manfred , Marx Steffen 
Published: May 2023

AbstractIn dieser Studie wurde der Einfluss verschiedener Lagerungsbedingungen auf die statische und dynamische Druckfestigkeit von drei Betonen (C20/25, C35/45 und C60/75) untersucht. Dabei wurden die Proben gezielt getrocknet und wassergesättigt und anschließend sowohl statisch als auch dynamisch geprüft. Die dynamischen Versuche wurden in einem Split‐Hopkinson‐Bar durchgeführt. Hierbei konnten je nach Betonfestigkeitsklasse Festigkeitssteigerungen von 200 bis 300 % bei Dehnraten im Bereich von 90 bis 160 1/s festgestellt werden. Im Vergleich zur Lagerung unter Umgebungsbedingungen sinkt die Druckfestigkeit durch die Trocknung aufgrund der Mikrorissbildung. Des Weiteren sinken die statischen und dynamischen Betondruckfestigkeiten von wassergesättigten Proben im Vergleich zu trockenen Proben. Dieser Abfall konnte sowohl unter statischer als auch unter dynamischer Beanspruchung beobachtet werden und ist unabhängig von der Dehnrate. Die trockenen Proben versagen explosionsartiger mit einer erhöhten Anzahl an Rissen und Bruchstücken im Vergleich zu wassergesättigten Proben. Weiterhin konnte am Beispiel zweier Fallturmversuche von einem trocken und einem wassergelagerten großformatigen Betonbauteil gezeigt werden, dass vorhandenes Porenwasser einen signifikanten Einfluss auf das Versagensbild und die Übertragung der Impaktbelastung in die Auflagerkonstruktion hat.Dieser Aufsatz wurde in ähnlicher Weise bereits in [1] veröffentlicht.
A case of hematohidrosis successfully treated with a beta‐blocker
Authors: Sha Yoshikazu , Yoshimura Hidekane , Saito Shoji , Kitoh Ryosuke , Takumi Yutaka 
Published: May 2023

Key Clinical MessageHematohidrosis is a rare disorder characterized by bloody sweating on the skin without trauma. The ear, nose, and other facial areas are the most commonly affected sites. This study shows usefulness of beta‐blockers in the treatment of hematohidrosis.
Case of giant appendicolith: A common ailment with a rare finding
Authors: Thapa Niranjan , Shrestha Oshan , Basukala Sunil , Shrestha Kala , Bhugai Nabaraj , Joshi Niraj , Regmi Shiva Kumar , Karki Sagun , Gurung Suman 
Published: May 2023

Key Clinical MessageGiant appendicoliths are rare appendicoliths with the largest diameter of more than 2 cm. It can increase the risk of complications such as perforation or abscess formation. This is a case of an uncommon definitive pathology diagnosed for a right iliac fossa calcification with a rare transoperative finding.
Kinetic Analysis of the Photochemical Paths in Asymmetric Diarylethene Dimer
Authors: Hiroyasu Yae , Higashiguchi Kenji , Shirakata Chihiro , Sugimoto Masataka , Matsuda Kenji 
Published: May 2023

AbstractAn asymmetric diarylethene dimer composed of 2‐ and 3‐thienylethene units linked by m‐phenylene developed various colors upon UV irradiation via an independent photochromic reaction on each unit. The change in contents and the other photoresponses of the photogenerated four isomers were analyzed using quantum yield for all the possible photochemical paths, i. e., photoisomerization, fluorescence, energy transfer, and the other non‐radiative paths. Almost all the rate constants of photochemical paths were calculated using measurable quantum yields and lifetimes. It was found that a significant contribution on photoresponse was the competition between photoisomerization and intramolecular energy transfer. The clear difference was observed in the photoresponses of the dimer and the 1 : 1 mixture solution of the model compounds. The m‐phenylene spacer appropriately regulated the rate of energy transfer in the asymmetric dimer, and the spacer enabled isolation of the excited state of the dimer, making the above quantitative analysis possible.
Determinants and consequences of corporate social responsibility decoupling—Status quo and limitations of recent empirical quantitative research
Authors: Velte Patrick 
Published: May 2023

AbstractThis study reviews recent empirical quantitative research on firm‐ and country‐related determinants of corporate social responsibility (CSR) decoupling and the consequences on firm value. Based on legitimacy theory and agency theory, top managers use CSR decoupling for self‐impression management and stakeholder attraction. Our review indicates that low (high) corporate governance quality increases (decreases) CSR decoupling and it has negative financial consequences for firms. We identify major research gaps and stress research recommendations for future CSR decoupling studies. Solid measures of CSR decoupling should compare quantitative performance measures and qualitative descriptions on CSR reports on strategies and processes. There is a great need to include automated text analyses of sustainability reports for future research designs. Due to extended regulations on CSR reporting from an international perspective, CSR decoupling remains a hot topic for researchers, business practice, and standard setters.
Impact of immunochemotherapy with R‐bendamustine or R‐CHOP for treatment naïve advanced‐stage follicular lymphoma: A subset analysis of the FOLL12 trial by Fondazione Italiana Linfomi
Authors: Nizzoli Maria E. , Manni Martina , Ghiggi Chiara , Pulsoni Alessandro , Musuraca Gerardo , Merli Michele , Califano Catello , Bari Alessia , Massaia Massimo , Conconi Annarita , Musto Pellegrino , Mannina Donato , Perrone Tommasina , Re Francesca , Galimberti Sara , Gini Guido , Capponi Monia , Vitolo Umberto , Usai Sara V. , Stefani Piero M. , Ballerini Filippo , Liberati Anna M. , Pennese Elsa , Pastore Domenico , Skrypets Tetiana , Catellani Hillary , Marcheselli Luigi , Federico Massimo , Luminari Stefano 
Published: May 2023

AbstractWe conducted a post hoc analysis of the FOLL12 trial to determine the impact of different initial immunochemotherapy (ICT) regimens on patient outcomes. Patients were selected from the FOLL12 trial, which included adults with stage II–IV follicular lymphoma (FL) grade 1–3a and high tumor burden. Patients were randomized 1:1 to receive either standard ICT followed by rituximab maintenance (RM) or the same ICT followed by a response‐adapted approach. ICT consisted of rituximab‐bendamustine (RB) or rituximab, cyclophosphamide, doxorubicin, and prednisone (R‐CHOP), per physician's decision. A total of 786 patients were included in this analysis, 341 of whom received RB and 445 R‐CHOP. RB was more frequently prescribed to older subjects, females, patients without bulky disease, and those with grade 1–2 FL. After a median of 56 months of follow‐up, R‐CHOP and RB had similar progression‐free survival (PFS) (Hazard Ratio for RB 1.11, 95% CI 0.87–1.42, p = 0.392). Standard RM was associated with improved PFS compared to response‐adapted management both after R‐CHOP and RB. Grade 3–4 hematologic adverse events were more frequent with R‐CHOP during induction treatment and more frequent with RB during RM. Grade 3–4 infections were more frequent with RB. RB was also associated with a higher incidence of transformed FL. R‐CHOP and RB showed similar activity and efficacy, but with different safety profiles and long‐term events, suggesting that the treating physician should carefully select the most appropriate chemotherapy regimen for each patient based on patient's individual characteristics, choices, and risk profile.
Harmonized Multisite MRI‐Based Quantification of Human Liver Fat and Stiffness: A Pilot Study
Authors: Carmichael Owen T. , Singh Maninder , Bashir Adil , Russell Anne M. , Bolding Mark , Redden David T. , Storrs Judd , Willoughby William R. , Howard‐Claudio Candace , Hsia Daniel S. , Kimberly Robert P. , Gray Meagan E. , Ravussin Eric , Denney Thomas S. 
Published: May 2023

BackgroundNonalcoholic fatty liver disease (NAFLD) is a leading cause of end‐stage liver disease. NAFLD diagnosis and follow‐up relies on a combination of clinical data, liver imaging, and/or liver biopsy. However, intersite imaging differences impede diagnostic consistency and reduce the repeatability of the multisite clinical trials necessary to develop effective treatments.Purpose/HypothesisThe goal of this pilot study was to harmonize commercially available 3 T magnetic resonance imaging (MRI) measurements of liver fat and stiffness in human participants across academic sites and MRI vendors.Study TypeCohort.SubjectsFour community‐dwelling adults with obesity.Field strength/Sequence1.5 and 3 T, multiecho 3D imaging, PRESS, and GRE.AssessmentHarmonized proton density fat fraction (PDFF) and magnetic resonance spectroscopy (MRS) protocols were used to quantify the FF of synthetic phantoms and human participants with obesity using standard acquisition parameters at four sites that had four different 3 T MRI instruments. In addition, a harmonized magnetic resonance elastography (MRE) protocol was used to quantify liver stiffness among participants at two different sites at 1.5 and 3 T field strengths. Data were sent to a single data coordinating site for postprocessing.Statistical TestsLinear regression in MATLAB, ICC analyses using SAS 9.4, one‐sided 95% confidence intervals for the ICC.ResultsPDFF and MRS FF measurements were highly repeatable among sites in both humans and phantoms. MRE measurements of liver stiffness in three individuals at two sites using one 1.5 T and one 3 T instrument showed repeatability that was high although lower than that of MRS and PDFF.ConclusionsWe demonstrated harmonization of PDFF, MRS, and MRE‐based quantification of liver fat and stiffness through synthetic phantoms, traveling participants, and standardization of postprocessing analysis. Multisite MRI harmonization could contribute to multisite clinical trials assessing the efficacy of interventions and therapy for NAFLD.Level of Evidence2Technical Efficacy Stage2
Localized model order reduction and domain decomposition methods for coupled heterogeneous systems
Authors: Discacciati Niccolò , Hesthaven Jan S. 
Published: May 2023

SummaryWe propose a model order reduction technique to accurately approximate the behavior of multi‐component systems without any a‐priori knowledge of the coupled model. In the offline phase, we construct independent surrogate models by solving the local problems with parametrized interface boundary conditions, while we combine them using domain decomposition techniques during the online phase. We show the potential of the proposed approach in terms of accuracy, computational performance and robustness in a series of test cases, including nonlinear and multi‐physics problems.
Energy harvesting by piezoelectric polyvinylidene fluoride/zinc oxide/carbon nanotubes composite under cyclic uniaxial tensile deformation
Authors: Kumar Ajeet , Jaiswal Satish , Joshi Rita , Yadav Siddharth , Dubey Anshu , Sharma Divyam , Lahiri Debrupa , Lahiri Indranil 
Published: May 2023

AbstractIn this study, polyvinylidene fluoride (PVDF)/zinc oxide (ZnO)/carbon nanotubes (CNT) nano‐reinforced composites were fabricated by solution casting method. Addition of ZnO and CNTs nanoparticles enhances the electroactive polar β‐phase of PVDF nanocomposites. Formation of β‐phase in the composites were examined by Fourier transform infrared spectroscopy and X‐ray diffraction analysis. Piezoelectric properties were investigated by applying uniaxial cyclic tensile deformation with the help of mechanical tensile tester device. The maximum generated voltage peak of 1.32 V was observed in the case of the nano‐reinforced composite having 15% ZnO, with maximum current of 0.61 μA and power of 0.66 μW. The fabricated PVDF/ZnO/CNTs nano‐reinforced composites can be a good candidate for human motion‐based energy harvesting applications during walking, running and so forth in which uniaxial deformation occurs.
A review on phytoestrogens: Current status and future direction
Authors: Patra Surendra , Gorai Sukhamoy , Pal Soumitra , Ghosh Kuntal , Pradhan Shrabani , Chakrabarti Sudipta 
Published: May 2023

AbstractPhytoestrogens are plant secondary metabolite that is structurally and functionally similar to mammalian estrogens, which have been shown to have various health benefits in humans. Isoflavones, coumestans, and lignans are the three major bioactive classes of phytoestrogens. It has a complicated mechanism of action involving an interaction with the nuclear estrogen receptor isoforms ERα and ERβ, with estrogen agonist and estrogen antagonist effects. Depending on their concentration and bioavailability in various plant sources, phytoestrogens can act as estrogen agonist or antagonists. Menopausal vasomotor symptoms, breast cancer, cardiovascular disease, prostate cancer, menopausal symptoms, and osteoporosis/bone health have all been studied using phytoestrogens as an additional standard hormone supplemental remedy. The botanical sources, techniques of identification, classification, side effects, clinical implications, pharmacological and therapeutic effects of their proposed mode of action, safety issues, and future directions for phytoestrogens have all been highlighted in this review.