bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concordance of Frozen Section Diagnosis of Epithelial Ovarian Neoplasm and Discussing the Diagnostic Pitfalls: An Institutional Experience
Authors: Sharma Jagannath D. , Kakoti Lopa M. , Ahmed Shiraj , Sarma Anupam , Barman Debabrat 
Published: March 2023

Abstract
Background Ovarian neoplasm is the third most common malignancy in Indian women. Intraoperative diagnosis becomes the critical guiding tool for the surgeons to take the decisions on the extent of surgery specially when preserving fertility has to be considered.
Aims and Objective The aim of this study is to evaluate the concordance of intraoperative diagnosis of frozen section (IFS) of ovarian epithelial neoplasm at our institute and to review and discuss the diagnostic pitfalls along with the review of literature.
Materials and Methods Data were archived from departmental record and the detailed clinical data of the patients were retrieved from hospital record system. The discordant cases were reviewed again in an attempt to address the pitfalls.
Statistical Analysis Diagnostic accuracy, sensitivity, specificity, and positive and negative predictive value of IFS of ovarian neoplasm were analyzed.
Results The overall frozen section diagnosis was concordant with final histopathology in 36 out of 44 cases (81%). The sensitivity of IFS diagnosis was found to be 100% for benign and borderline tumors, whereas 88.9% for malignant epithelial tumors, but the correctness of diagnosis is high only for benign and malignant tumors (high positive predictive value) in compared with borderline ones. The diagnostic pitfalls were identified individually in discordant cases.
Conclusion An accurate interpretation of IFS in ovarian epithelial malignancy can be achieved in benign and malignant cases, but limited in borderline tumors. Awareness of the artifacts and the limitations in mind and the IFS diagnosis can be of great help for proper management of the ovarian neoplasm.
Marching Ahead through the Pandemic: Continuing Anesthesia Services in COVID Era—Our Experience from a Tertiary Care Cancer Centre
Authors: Bhan Swati , Gupta Raghav , Vig Saurabh , Garg Rakesh , Gupta Nishkarsh , Kumar Vinod , Bharati Sachidanand Jee , Mishra Seema , Ratre Brajesh , Pandit Anuja , Sirohiya Prashant , Singh Ram , Kumar Balbir , Bhopale Shweta , Bhatnagar Sushma 
Published: March 2023

Introduction This paper aims to provide an overview of the administrative and clinical preparations done in a tertiary care cancer hospital in continuing operation theatre (OT) services through the COVID pandemic.
Methods Retrospective data collection, data for the past 1.5 years (COVID period) March 2020 to August 2021 were compared to surgical output for a similar duration of time before the COVID era (September 2018–February 2020).
Results A total of 1,022 surgeries were done under anesthesia in the COVID period as against 1,710 surgeries done in a similar time frame in the pre-COVID era. Overall, we saw a 40%drop in the total number of cases. Thorax, abdominal, and miscellaneous surgeries (soft tissue sarcomas, urology, and gyneconcology) saw a maximum fall in numbers; however, head and neck cases saw an increase in numbers during the pandemic. Surgical morbidity and mortality were similar in the COVID and pre-COVID era. No cases of severe COVID infection were reported among the healthcare staff working in OT.
Discussion We could successfully continue our anesthesia services with minimal risk to healthcare staff throughout the pandemic by adopting major guidelines in a pragmatic and practical approach with minor changes to suit our setup.
Everolimus as a therapeutic option in refractory epilepsy in children with tuberous sclerosis: a systematic review
Authors: Menezes Catarina Ester Gomes , Santos Débora Lopes dos , Nery Erick Santos , Serpa Evelin Duarte , Morais Lécio Aragão Souza , Dutra Lucas Santana , Portela Filho Marcos Baruch , Goes Julieta Sobreira 
Published: March 2023

Abstract
Background Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some evidence suggests that its use benefits the treatment of refractory epilepsy in these patients.
Objective To evaluate the efficacy of everolimus in controlling refractory epilepsy in children with TS.
Methods A literature review was conducted in the Pubmed, BVS, and Medline databases, using the descriptors Tuberous sclerosis, Children, Epilepsy, and Everolimus. Original clinical trials and prospective studies published in Portuguese or English in the last decade that evaluated the use of everolimus as an adjuvant therapy in the control of refractory epilepsy in pediatric patients with TS were included.
Results Our search screened 246 articles from electronic databases, 6 of which were chosen for review. Despite the methodological variations between the studies, most patients benefited from the use of everolimus to control refractory epilepsy, with response rates ranging from 28.6 to 100%. Adverse effects were present in all studies leading to dropouts of some patients; however, the majority were of low severity.
Conclusion The selected studies suggest a beneficial effect of everolimus in the treatment of refractory epilepsy in children with TS, despite the adverse effects observed. Further studies involving a larger sample in double-blind controlled clinical trials should be performed to provide more information and statistical credibility.
BRAF V600E Mutations and Beyond: A Molecular Perspective of Melanoma from a Tertiary Cancer Referral Center of India
Authors: Vengurlekar Vaibhavi , Shetty Omshree , Gurav Mamta , Bapat Prachi , Karnik Nupur , Wagh Gauri , Epari Sridhar , Rekhi Bharat , Ramadwar Mukta , Desai Sangeeta 
Published: March 2023

Objectives Malignant melanoma demonstrates frequently occurring mutations of genes in the serine/threonine kinase pathway, namely BRAF, NRAS, and neurofibromin 1. There is rare documentation of a detailed analysis of these mutations in cases of melanoma among Indian patients. We present molecular features in cases of malignant melanoma, diagnosed at a tertiary cancer referral center in India, over a period of 8 years (2011–2018).Materials and Methods This study was performed on formalin fixed paraffin embedded tissues of 88 histologically confirmed cases of malignant melanoma. BRAF gene alterations were studied by both Sanger sequencing and real-time polymerase chain reaction techniques (n = 74). Molecular testing for BRAF and NRAS gene alterations was accomplished in 74/88 cases (80%). Molecular test results were correlated with clinicopathological features using IBM SPSS Statistical software 25.0.Results The age ranged from 13 to 79 years (median = 57), with a M:F ratio of 1.4:1. BRAF mutations were observed in 12/74 (16.21%) patients, including V600E (n = 7), A594T (n = 1), T599 = (n = 2), V600K (n = 1), and Q612P (n = 1), while NRAS mutations were observed in 6/38 (15.7%) patients. Among various subtypes, nodular melanoma was the most frequent subtype (33%) among cutaneous malignant melanomas. Among non-cutaneous melanomas, mucosal melanomas were observed in 37.5% of cases.Conclusion This constitutes one of the few reports on comprehensive analysis of molecular alterations underlying melanomas in Indian patients. A larger sample size, with more extensive molecular markers, would yield additional information on the disease manifestation.
Axial Skeleton Bone Marrow Changes in Inflammatory Rheumatologic Disorders
Authors: Reijnierse Monique 
Published: March 2023

AbstractMagnetic resonance imaging (MRI) of the axial skeleton, spine, and sacroiliac (SI) joints is critical for the early detection and follow-up of inflammatory rheumatologic disorders such as axial spondyloarthritis, rheumatoid arthritis, and SAPHO/CRMO (synovitis, acne, pustulosis, hyperostosis, and osteitis/chronic recurrent multifocal osteomyelitis). To offer a valuable report to the referring physician, disease-specific knowledge is essential. Certain MRI parameters can help the radiologist provide an early diagnosis and lead to effective treatment. Awareness of these hallmarks may help avoid misdiagnosis and unnecessary biopsies. A bone marrow edema-like signal plays an important role in reports but is not disease specific. Age, sex, and history should be considered in interpreting MRI to prevent overdiagnosis of rheumatologic disease. Differential diagnoses—degenerative disk disease, infection, and crystal arthropathy—are addressed here. Whole-body MRI may be helpful in diagnosing SAPHO/CRMO.
The Many Faces of Marrow Necrosis
Authors: Mourad Charbel , Omoumi Patrick , Vande Berg Bruno 
Published: March 2023

AbstractDepending on the age and location within the skeleton, bone marrow can be mostly fatty or hematopoietic, and both types can be affected by marrow necrosis. This review article highlights the magnetic resonance imaging findings of disorders in which marrow necrosis is the dominant feature.Fatty marrow necrosis is detected on T1-weighted images that show an early and specific finding: the reactive interface. Collapse is a frequent complication of epiphyseal necrosis and detected on fat-suppressed fluid-sensitive sequences or using conventional radiographs. Nonfatty marrow necrosis is less frequently diagnosed. It is poorly visible on T1-weighted images, and it is detected on fat-suppressed fluid-sensitive images or by the lack of enhancement after contrast injection.Pathologies historically “misnamed” as osteonecrosis but do not share the same histologic or imaging features of marrow necrosis are also highlighted.
Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study
Authors: Bikdeli Behnood , Muriel Alfonso , Wang Yun , Piazza Gregory , Khairani Candrika D. , Rosovsky Rachel P. , Mehdipoor Ghazaleh , O'Donoghue Michelle L. , Madridano Olga , Lopez-Saez Juan Bosco , Mellado Meritxell , Brasero Ana Maria Diaz , Grandone Elvira , Spagnolo Primavera A. , Lu Yuan , Bertoletti Laurent , López-Jiménez Luciano , Núñez Manuel Jesús , Blanco-Molina Ángeles , Gerhard-Herman Marie , Goldhaber Samuel Z. , Bates Shannon M. , Jimenez David , Krumholz Harlan M. , Monreal Manuel ,   The RIETE Investigators
Published: March 2023

AbstractSex-specific factors are implicated in pulmonary embolism (PE) presentation in young patients, as indicated by increased risk in pregnancy. Whether sex differences exist in PE presentation, comorbidities, and symptomatology in older adults, the age group in which most PEs occur, remains unknown. We identified older adults (aged ≥65 years) with PE in a large international PE registry replete with information about relevant clinical characteristics (RIETE registry, 2001–2021). To provide national data from the United States, we assessed sex differences in clinical characteristics and risk factors of Medicare beneficiaries with PE (2001–2019). The majority of older adults with PE in RIETE (19,294/33,462, 57.7%) and in the Medicare database (551,492/948,823, 58.7%) were women. Compared with men, women with PE less frequently had atherosclerotic diseases, lung disease, cancer, or unprovoked PE, but more frequently had varicose veins, depression, prolonged immobility, or history of hormonal therapy (p < 0.001 for all). Women less often presented with chest pain (37.3 vs. 40.6%) or hemoptysis (2.4 vs. 5.6%) but more often with dyspnea (84.6 vs. 80.9%) (p < 0.001 for all). Measures of clot burden, PE risk stratification, and use of imaging modalities were comparable between women and men. PE is more common in elderly women than in men. Cancer and cardiovascular disease are more common in men, whereas transient provoking factors including trauma, immobility, or hormone therapy are more common in elderly women with PE. Whether such differences correlate with disparities in treatment or differences in short- or long-term clinical outcomes warrants further investigation.
Landau theory for finite-time dynamical phase transitions
Authors: Meibohm Jan , Esposito Massimiliano 
Published: March 2023

Abstract
We study the time evolution of thermodynamic observables that characterise the dissipative nature of thermal relaxation after an instantaneous temperature quench. Combining tools from stochastic thermodynamics and large-deviation theory, we develop a powerful theory for computing the large-deviation statistics of such observables. Our method naturally leads to a description in terms of a dynamical Landau theory, a versatile tool for the analysis of finite-time dynamical phase transitions. The topology of the associated Landau potential allows for an unambiguous identification of the dynamical order parameter and of the phase diagram. As an immediate application of our method, we show that the probability distribution of the heat exchanged between a mean-field spin model and the environment exhibits a singular point, a kink, caused by a finite-time dynamical phase transition. Using our Landau theory, we conduct a detailed study of the phase transition. Although the manifestation of the new transition is similar to that of a previously found finite-time transition in the magnetisation, the properties and the dynamical origins of the two turn out to be very different.
Gate reflectometry in dense quantum dot arrays
Authors: Ansaloni Fabio , Bohuslavskyi Heorhii , Fedele Federico , Rasmussen Torbjørn , Brovang Bertram , Berritta Fabrizio , Heskes Amber , Li Jing , Hutin Louis , Venitucci Benjamin , Bertrand Benoit , Vinet Maud , Niquet Yann-Michel , Chatterjee Anasua , Kuemmeth Ferdinand 
Published: March 2023

Abstract
Silicon quantum devices are maturing from academic single- and two-qubit devices to industrially-fabricated dense quantum-dot (QD) arrays, increasing operational complexity and the need for better pulsed-gate and readout techniques. We perform gate-voltage pulsing and gate-based reflectometry measurements on a dense 2 × 2 array of silicon QDs fabricated in a 300 mm-wafer foundry. Utilizing the strong capacitive couplings within the array, it is sufficient to monitor only one gate electrode via high-frequency reflectometry to establish single-electron occupation in each of the four dots and to detect single-electron movements with high bandwidth. A global top-gate electrode adjusts the overall tunneling times, while linear combinations of side-gate voltages yield detailed charge stability diagrams. To test for spin physics and Pauli spin blockade at finite magnetic fields, we implement symmetric gate-voltage pulses that directly reveal bidirectional interdot charge relaxation as a function of the detuning between two dots. Charge sensing within the array can be established without the involvement of adjacent electron reservoirs, important for scaling such split-gate devices towards longer 2 × N arrays. Our techniques may find use in the scaling of few-dot spin-qubit devices to large-scale quantum processors.
Modelling chromosome-wide target search
Authors: Hedström Lucas , Lizana Ludvig 
Published: March 2023

Abstract
The most common gene regulation mechanism is when a transcription factor (TF) protein binds to a regulatory sequence to increase or decrease RNA transcription. However, TFs face two main challenges when searching for these sequences. First, the sequences are vanishingly short relative to the genome length. Second, there are many nearly identical sequences scattered across the genome, causing proteins to suspend the search. But as pointed out in a computational study of LacI regulation in Escherichia coli, such almost-targets may lower search times if considering DNA looping. In this paper, we explore if this also occurs over chromosome-wide distances. To this end, we developed a cross-scale computational framework that combines established facilitated-diffusion models for basepair-level search and a network model capturing chromosome-wide leaps. To make our model realistic, we used Hi-C data sets as a proxy for 3D proximity between long-ranged DNA segments and binding profiles for more than 100 TFs. Using our cross-scale model, we found that median search times to individual targets critically depend on a network metric combining node strength (sum of link weights) and local dissociation rates. Also, by randomizing these rates, we found that some actual 3D target configurations stand out as considerably faster or slower than their random counterparts. This finding hints that chromosomes’ 3D structure funnels essential TFs to relevant DNA regions.
A plasma chemistry model for H2/SiH4 mixtures used in PECVD processes
Authors: Sushkov Vladimir , Rachdi Lazhar , Hofmann Marc 
Published: March 2023

Abstract
Plasma chemical processes in H2/SiH4 discharges are critically reviewed. A model set of reactions is proposed which includes temperature and pressure-dependent reaction rates and describes SiyHx (y ≤ 3) chemistry. Using a 2D fluid plasma simulator, the model has been tested under three different set of operating conditions. First, it has been validated against the experimental benchmark data (Horvath and Gallagher (2009) J. Appl. Phys.
105, 13304). Based on considerations of atomic hydrogen content, the branching of SiH4 dissociation channels and the H surface loss probability have been defined more accurately. Then, simulations have been also performed for the plasma source of a PECVD tool from Meyer Burger Germany. A very good agreement between the computed and experimentally determined deposition rates can be stated.
The instability analysis of self-gravitation systems under the perturbation with orbital angular momentum
Authors: Yang Qiaoyun , Tan Ling , Chen Hui , Liu Sanqiu 
Published: March 2023

Abstract
Based on plasma kinetic theory, the instabilities of self-gravitation systems under perturbation with orbital angular momentum (OAM) are investigated, and the concept of twisted Jeans mode is introduced to describe the new phenomenon. The result shows that the growth rate of the Jeans instability is enhanced with the OAM parameter increased, while the critical wave number is consistent with the classical Jeans critical value. It is expected that the present results would give more insight into the evolution and dynamics of a self-gravitational system.
Gauging universe expansion via scalar fields
Authors: Kumar Devanarayanan Rajeeb , Pathak S.D. , Ojha Vikash Kumar 
Published: March 2023

Abstract
In this study, we investigate the expansion of the FRLW universe in the open, closed, and flat geometries. The universe is dominated by a scalar field (spatially homogeneous) as a source of dark energy. We consider the three different classes of scalar fields – quintessence, tachyonic, and phantom field – for our analysis. A mathematical analysis is carried out by considering these three scalar fields with exponential and power-law potentials. Both potentials give exponential expansion in the open, closed, and flat FRLW universes. It is found that quintessence, tachyonic, and phantom scalar fields are indistinguishable under the slow roll approximation.
Investigation on the Formation of Herringbone Structure in Type II Solar Radio Bursts
Authors: Abidin Z. Z. , Zulkiplee A. N. , Epin V. , Pauzi F. A. M. 
Published: March 2023

Abstract
We report detailed observation of the “herringbone” of a Type II solar radio burst that occurred on 2010 November 3rd. Data from the Space Weather Prediction Center, National Oceanic and Atmospheric Administration, e-CALLISTO, and Nançay RadioHeliograph are analyzed. We determine the brightness temperature and degree of circular polarization of the “herringbone” burst. Correlations between the physical parameters and the “herringbone” are examined. Based on the relationship, this is the first study that suggested this “herringbone” was generated through fundamental plasma.
New Photometric Investigations of G-type Contact Binary TU Boo
Authors: Wang Jing-jing , Guo Meng , Jiang Lin-qiao , Zhang Bin 
Published: March 2023

Abstract
Two sets of CCD photometric observations for contact binary TU Boo were obtained in 2020 and 2021. Different from its asymmetric light curves published from the literature, our BVR

c

I

c
-band curves show that the heights of maximum are almost equal. These distortions of light curves possibly indicate that the components were active in past 25 yr, but they were stable in the last two years. For total-eclipse binary TU Boo, due to some star-spots on the surface of the components, the physical structure obtained by many investigators are different. Therefore, the symmetric multi-color light curves in 2020, 2021 are important for understanding configuration and evolution of this system. By using the Wilson–Devinney program, it is confirmed that TU Boo is an A-type shallow-contact binary with the temperature difference of ΔT = 152 K and fill-out of f = 14.67%. In the O−C diagram of orbital period analysis, a cyclic oscillation superimposed on a continuous decrease was determined. The long-term decreasing is often explained by the mass transfer from the more massive star to less massive one, this system will evolve into a deeper contact binary with time. The cyclic oscillations computed from much more CCD times of light minimum maybe result from the light-travel time effect via the presence of a third body. These characters of structure, evolution and ternary belong to typical A-type W UMa binaries with spectral G.
Constraints on Dark Energy from the CSST Galaxy Clusters
Authors: Zhang Yufei , Chen Mingjing , Wen Zhonglue , Fang Wenjuan 
Published: March 2023

Abstract
We study the potential of the galaxy cluster sample expected from the Chinese Space Station Telescope (CSST) survey to constrain dark energy properties. By modeling the distribution of observed cluster mass for a given true mass to be log-normal and adopting a selection threshold in the observed mass M
200m
≥ 0.836 × 1014
h
−1
M
⊙, we find about 4.1 × 105 clusters in the redshift range 0 ≤ z ≤ 1.5 can be detected by the CSST. We construct the Fisher matrix for the cluster number counts from CSST, and forecast constraints on dark energy parameters for models with constant (w
0CDM) and time dependent (w
0
w

a
CDM) equation of state. In the self-calibration scheme, the dark energy equation of state parameter w
0 of the w
0CDM model can be constrained to Δw
0 = 0.036. If w

a
is added as a free parameter, we obtain Δw
0 = 0.077 and Δw

a
= 0.39 for the w
0
w

a
CDM model, with a Figure of Merit for (w
0, w

a
) of 68.99. Should we have perfect knowledge of the observable-mass scaling relation (“known SR” scheme), we would obtain Δw
0 = 0.012 for the w
0CDM model, and Δw
0 = 0.062 and Δw

a
= 0.24 for the w
0
w

a
CDM model. The dark energy Figure of Merit of (w
0, w

a
) increases to 343.25. This indicates again the importance of calibrating the observable-mass scaling relation for optically selected galaxy clusters. By extending the maximum redshift of the clusters from

z

max

∼
1.5

to

z

max

∼
2

, the dark energy Figure of Merit for (w
0, w

a
) increases to 89.72 (self-calibration scheme) and 610.97 (“known SR” scheme), improved by a factor of ∼1.30 and ∼1.78, respectively. We find that the impact of clusters’ redshift uncertainty on the dark energy constraints is negligible as long as the redshift error of clusters is smaller than 0.01, achievable by CSST. We also find that the bias in logarithm mass must be calibrated to be 0.30 or better to avoid significant dark energy parameter bias.