bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning
Authors: Fleischer Pierson , Abbasi Aamir , Fealy Andrew W. , Danielsen Nathan P. , Sandhu Ramneet , Raj Philip R. , Gulati Tanuj 
Published: February 2023

AbstractThe motor cortex controls skilled arm movement by recruiting a variety of targets in the nervous system, and it is important to understand the emergent activity in these regions as refinement of a motor skill occurs. One fundamental projection of the motor cortex (M1) is to the cerebellum. However, the emergent activity in the motor cortex and the cerebellum that appears as a dexterous motor skill is consolidated is incompletely understood. Here, we report on low-frequency oscillatory (LFO) activity that emerges in cortico-cerebellar networks with learning the reach-to-grasp motor skill. We chronically recorded the motor and the cerebellar cortices in rats, which revealed the emergence of coordinated movement-related activity in the local-field potentials as the reaching skill consolidated. Interestingly, we found this emergent activity only in the rats that gained expertise in the task. We found that the local and cross-area spiking activity was coordinated with LFOs in proficient rats. Finally, we also found that these neural dynamics were more prominently expressed during accurate behavior in the M1. This work furthers our understanding on emergent dynamics in the cortico-cerebellar loop that underlie learning and execution of precise skilled movement.
Validation of a New Coil Array Tailored for Dog Functional Magnetic Resonance Imaging Studies
Authors: Guran Catherine-Noémie Alexandrina , Sladky Ronald , Karl Sabrina , Boch Magdalena , Laistler Elmar , Windischberger Christian , Huber Ludwig , Lamm Claus 
Published: February 2023

AbstractComparative neuroimaging allows for the identification of similarities and differences between species. It provides an important and promising avenue, to answer questions about the evolutionary origins of the brain´s organization, in terms of both structure and function. Dog functional magnetic resonance imaging (fMRI) has recently become one particularly promising and increasingly used approach to study brain function and coevolution. In dog neuroimaging, image acquisition has so far been mostly performed with coils originally developed for use in human MRI. Since such coils have been tailored to human anatomy, their sensitivity and data quality is likely not optimal for dog MRI. Therefore, we developed a multichannel receive coil (K9 coil, read “canine”) tailored for high-resolution functional imaging in canines, optimized for dog cranial anatomy. In this paper we report structural (n = 9) as well as functional imaging data (resting-state,n = 6; simple visual paradigm,n = 9) collected with the K9 coil in comparison to reference data collected with a human knee coil. Our results show that the K9 coil significantly outperforms the human knee coil, improving the signal-to-noise ratio (SNR) across the imaging modalities. We noted increases of roughly 45% signal-to-noise in the structural and functional domain. In terms of translation to fMRI data collected in a visual flickering checkerboard paradigm, group-level analyses show that the K9 coil performs better than the knee coil as well. These findings demonstrate how hardware improvements may be instrumental in driving data quality, and thus, quality of imaging results, for dog-human comparative neuroimaging.
Individual Variability in Performance Reflects Selectivity of the Multiple Demand Network among Children and Adults
Authors: Schettini Elana , Hiersche Kelly J. , Saygin Zeynep M. 
Published: February 2023

Executive function (EF) is essential for humans to effectively engage in cognitively demanding tasks. In adults, EF is subserved by frontoparietal regions in the multiple demand (MD) network, which respond to various cognitively demanding tasks. However, children initially show poor EF and prolonged development. Do children recruit the same network as adults? Is it functionally and connectionally distinct from adjacent language cortex, as in adults? And is this activation or connectivity dependent on age or ability? We examine task-dependent (spatial working memory and passive language tasks) and resting state functional data in 44 adults (18-38 years, 68% female) and 37 children (4-12 years, 35% female). Subject-specific functional ROIs (ss-fROIs) show bilateral MD network activation in children. In both children and adults, these MD ss-fROIs are not recruited for linguistic processing and are connectionally distinct from language ss-fROIs. While MD activation was lower in children than in adults (even in motion- and performance-matched groups), both showed increasing MD activation with better performance, especially in right hemisphere ss-fROIs. We observe this relationship even when controlling for age, cross-sectionally and in a small longitudinal sample of children. These data suggest that the MD network is selective to cognitive demand in children, is distinct from adjacent language cortex, and increases in selectivity as performance improves. These findings show that neural structures subserving domain-general EF emerge early and are sensitive to ability even in children. This research advances understanding of how high-level human cognition emerges and could inform interventions targeting cognitive control.SIGNIFICANCE STATEMENTThis study provides evidence that young children already show differentiated brain network organization between regions that process cognitive demand and language. These data support the hypothesis that children recruit a similar network as adults to process cognitive demand; and despite immature characteristics, children's selectivity looks more adult-like as their executive function ability increases. Mapping early stages of network organization furthers our understanding of the functional architecture underlying domain-general executive function. Determining typical variability underlying cognitive processing across developmental periods helps establish a threshold for executive dysfunction. Early markers of dysfunction are necessary for effective early identification, prevention, and intervention efforts for individuals struggling with deficits in processing cognitive demand.
Saving the People Congress Forgot
Authors: Linda Evans Charles D. Weisselberg 
Published: February 2023

Lost among more than 150,000 federal prisoners is a small cohort of “old law” people who have served many decades in custody. They were sentenced for offenses committed prior to November 1987, when the Federal Sentencing Guidelines went into effect. These are some of the oldest and most vulnerable people in the federal system, and least likely to re-offend. The possibility of release for most of them lies with the U.S. Parole Commission, a dysfunctional government agency. Unlike other federal prisoners, old law people cannot ask a court for compassionate release.
The Commission was scheduled to go out of business in 1992, but instead its role has changed and it has been continually re-authorized, currently through October 2023. But as the article explains, the Commission is a failed agency: it has lost track of old law people and has not reported accurately to Congress. Further, the Agency was created to oversee a vastly different population than the aging and medically vulnerable people under its jurisdiction now.
The article recommends amending the First Step Act to allow all old law people to apply for compassionate release under the same procedures available to new law prisoners. Congress should not continue to re-authorize the Parole Commission. Parole authority should be transferred to U.S. magistrate judges, to apply release criteria more suited to an elderly population. Finally, clemency petitions for everyone sentenced under the old law should be prioritized by President Biden.
The Impact of Non-English Language Preference on Pediatric Hospital Outcomes
Authors: Pilarz Mary , Rodriguez Giselle , Jackson Kathryn , Rodriguez Victoria A. 
Published: February 2023

OBJECTIVES
To characterize the relationship between non-English language preference (NELP) and hospital outcomes including length of stay (LOS), time of discharge, emergency department return visits, readmissions, and cost for pediatric general medicine inpatients.

METHODS
We conducted a retrospective analysis at an urban, quaternary care, free-standing children’s hospital. Patients ages 0 to 18 admitted to any general medicine service between January 1, 2017, and December 31, 2019 were included. Patients were divided into 3 language preference categories: English, Spanish, and non-Spanish NELP. Single and multifactor regression analysis was used to model differences in outcome measures by language preference adjusted for technology dependence.

RESULTS
A total of 4820 patients met criteria. In adjusted models, the average LOS for English-speaking patients was 126 hours; LOS for patients who preferred Spanish was not significantly different, whereas LOS for patients with non-Spanish NELP was 50% longer (P &lt; .001). English-speaking patients were discharged earliest in the day (mean 3:08 pm), with patients who preferred Spanish discharged 0.5 hours later and patients with non-Spanish NELP discharged 1.1 hours later than English-speaking patients (P &lt; .001). Patients with NELP were found to be technology-dependent more frequently (P &lt; .001) than the English preference group. Emergency department return visits, readmissions, and cost were not significantly different between groups.

CONCLUSIONS
NELP was associated with longer length of stay and discharges later in the day. The most pronounced differences occurred in patients with non-Spanish NELP who also had more frequent technology dependence and more limited access to interpreters.
Psychedelic therapy as reality transformation: A phenomenological approach
Authors: Sanchez Petrement Mateo 
Published: February 2023

AbstractCoinciding with and responding to a growing crisis in the diagnostic, explanatory and treatment systems of psychiatry, the last couple of decades have seen a growing amount of evidence regarding the therapeutic potential of psychedelic drugs to treat a variety of mental health conditions. Broadly, this crisis can be construed as that of “indivi/dualist” approaches which aim to treat patients who are construed as separated from their social and material contexts, which are taken as given. The implicit premise: the self, but not the world, is the site of therapeutic intervention. By contrast, researchers insist that psychedelic therapy functions by on producing an experience of “connectedness” to self, world, and others, which is heavily influenced by context. However, by remaining in an indivi/dualist thoughtspace, neurological and psychological perspectives betray these recurring themes. In this essay, I approach psychedelic therapy for depression through the lens of phenomenological psychiatry to take these themes seriously–a task which passes by considering experience as embodied, and therefore embedded. Starting off from an analysis of depression as a bodily detunement (disconnection), I argue that, through a process of “immersive reflection”, psychedelic therapy transforms not only the self, but patients’ sense of reality. This will allow me to answer several questions pertaining to psychedelic therapy regarding its therapeutic mechanism, why it transforms reality and not only the self, why it transforms and not merely amplifies experience, why its effects last beyond the drugs’ psychoactive duration, and in what their paradigm-shifting potential for mental health consists of.
Comparative Structure of Male Mortality From Cardiac Causes in Five-Year Age Groups
Authors: Drapkina O. M. , Samorodskaya I. V. 
Published: February 2023

Aim To study the nosological structure of male mortality in 5-year age groups (15–85+) and the contribution of cardiac causes to all-cause mortality in 2020; to discuss the correctness of statistical recording of causes of cardiac death.Material and methods Data source: Center for Demographic Research of the Russian School of Economy http://demogr.nes.ru / index.php / ru / demogr_indicat / agreement. The selected indexes were all-cause death, causes of the class of circulatory diseases (CD) according to the International Classification of Diseases, Tenth Revision (ICD-10) (class IX, codes I00–I99), and cardiac causes of death (codes I00–I40, I70, I67.4, Q20–28) in 5-year age groups.Results Proportions of CD and cardiac causes in the male all-cause mortality were almost identical in the age groups younger than 30 years. Then the proportion of cardiac deaths remained almost unchanged (30–34 %) in contrast to the rapid growth of the CD proportion (to 51 % with a maximum at 75–79 years). Until the age of 45 years, more than 50% of cardiac deaths were caused by heart defects and cardiomyopathies and more than 25% by acute forms of ischemic heart disease (IHD); in older groups, their proportions decreased but the mortality increased. In the age groups younger than 50 years, the mortality from “Other forms of acute IHD” (ICD codes I20, I24.1–9 counted as one line) was higher than the mortality from myocardial infarction (MI); after 50 years, the MI mortality became higher. The combined proportion of two groups in the mortality from cardiac causes was maximal at the age of 20–24 years (31 %), then it decreased to a minimum of 9 % at the age of 85+. The mortality from and the proportions of chronic forms of IHD (more than 50% of which have no clear criteria for diagnosis and death), arterial hypertension, “Myocardial degeneration” (ICD code I51.5), and “Pulmonary heart and pulmonary circulation disorders” (ICD codes I26–I28) rapidly grow with increasing age. Existing approaches to recording the causes of death do not allow assessment of the contribution and mortality rates from a number of cardiac diseases.Conclusion Mortality reduction programs should provide more accurate recording of the causes of death and take into account age-related features of the nosological structure of cardiac mortality.
Prediction of massive coronary thrombosis of the infarct-related artery in ST-elevation myocardial infarction
Authors: Azarov A. V. , Zhuravlev A. S. , Glezer M. G. , Semitko S. P. , Kovalchuk I. A. , Ioseliani D. G. 
Published: February 2023

Aim To identify clinical, laboratory and angiographic predictors for development of massive coronary thrombosis in patients with ST-segment elevation myocardial infarction (STEMI).Material and methods This prospective, single-site study included 137 patients with STEMI (mean age, 66.5±13.2 years). Among these patients, 59 were in the group of massive coronary thrombosis and 78 patients were in the group of minor thrombosis. To identify predictors for the development of massive coronary thrombosis, medical history data, blood count and biochemistry, coagulogram, and angiography data were analyzed. A predictive model was constructed using the method of binary logistic regression followed by a search for the optimum value of the prognostic function with a ROC analysis. Results The study showed statistically significant roles of total bilirubin, platelets, prothrombin ratio (PTR), activated partial thromboplastin time (APTT), and presence of inferior myocardial infarction in prediction of massive coronary thrombosis in STEMI. The model sensitivity was 71.2 %, specificity 75.6 %, and overall diagnostic efficacy 73.7 %.Conclusion The predictive model for the development of massive coronary thrombosis in STEMI based on laboratory and instrumental data potentially allows assessing the thrombus load in the infarction-involved coronary artery and determining the optimum tactics of percutaneous coronary intervention in patients with STEMI. This reduces the probability of distal embolization with fragments of the disintegrated thrombus and improves the prognosis of STEMI patients both during the stay in the hospital and in the long-term. According to results of this study, the prognostic model for massive coronary thrombosis in STEMI based on such indexes as the platelet count, PTR, APTT, total bilirubin, and presence of inferior myocardial infarction provides accurate predictions in 73.7 % of cases. Independent predictors of massive coronary thrombosis were inferior myocardial infarction and total bilirubin.
The effectiveness of slow paced breathing on pain perception during first stage of labour among primigravida mothers
Authors: Tiwari Vandana , Kumar Anu V. 
Published: February 2023

Natural childbirth is a profound and powerful human experience which is a mixture of feeling of empowerment and accomplishment. Both pharmacological and non-pharmacological methods are available today and it is known that the non- pharmacological options involve less risk when used in this process. Breathing exercises helps labour women to relax and distract from the painful response. The research design adopted for this study was quasi experimental design. The sample size was 60 (30 experimental and 30 control group) and was drawn through purposive sampling technique. The level of labour pain perception was assessed by using Numeric pain rating scale. Slow paced breathing was instructed to practice during contractions for 2 hours during active phase for experimental group. Pre-test was assessed before intervention and Post test done after intervention for both group. The data gathered were analyzed by descriptive and inferential statistical method. The mean post-test score on level of pain perception during first stage of labour in experimental group was 1.6, but in control group it was 2.5. The calculated unpaired„ t‟ value was 5.92, which is more than the table value at 5% significance (table value=2.02). Hence, it was statistically significant at 5% (p&#60;0.05). It shows that slow paced breathing is effective in reduction of pain perception during first stage of labour. Hence, the research hypothesis (H1) is accepted. There is no significant association between demographic variables. Hence, the research hypothesis (H2) is rejected. This study finding revealed that slow paced breathing exercise helps in reducing the level of pain perception among primigravida mothers in the experimental group. So this can be practiced as a Non-pharmacological method to relieve pain perception during labour in various settings.
Patients with Patellofemoral Pain Exhibiting Decrease Vertical Ground Reaction Force Compared to Healthy Individuals during Weight Bearing Tasks: A Systematic Reviews and Meta-Analysis
Authors: Yalfani Ali , Ahmadi Mohamadreza 
Published: February 2023

Background: Vertical ground reaction force (VGRF) can lead to the development knee osteoarthritis. This review systematic and meta-analysis aimed to investigate the VGRF in patellofemoral pain patients (PFP) during weight bearing tasks.
Methods: Search strategy was conducted in databases: Science Direct, Scopus, PubMed and Google Scholar from Sep 2020 to Jun 2021. The VGRF components we measured were passive impact (Fz1)/peak and propulsion/active peak (Fz2). The quality of the studies was evaluated with Down and Black index and it was divided into three groups: low quality (LQ), medium quality (MQ) and high quality (HQ). The standardized mean difference between PFP and healthy individuals was used to calculate the effect size.
Results: Nine articles were selected for systematic review and meta-analysis of which 5 studies was HQ, 3 studies were MQ and 1 study was LQ were classified. PFP compared to healthy individuals with moderate and small effect size have reduced impact and propulsion respectively.
Conclusion: The in PFP, VGRF is influenced psychological, behavioral and biomechanical factors. Therefore, psychosomatic therapeutic approaches may have a long time effectiveness on the rehabilitation of PFP.
Health System Governance Evaluation: A Scoping Review
Authors: Farough Khosravi Mohammad , Mosadeghrad Ali Mohammad , Arab Mohammad 
Published: February 2023

Background: Governance is one of the critical functions of the health system. Good governance of the health system leads to better performance and outcomes. Evaluation is the first step to improving health system governance. Therefore, this research aimed to identify evaluation tools for health system governance.
Methods: In the current scoping review, we searched all documents related to health system governance evaluation indexed in Medline, EMBASE, ProQuest, Scopus, Cochrane Library, Science Direct databases, and Google Scholar search engines to 2022, extracted, and assessed. Finally, documents were selected and analyzed by thematic analysis.
Results: Thirty tools were found to evaluate health system governance. Among the proposed tools, 11 specific tools have been designed just for health system governance evaluation, while others have governance as a component of health system evaluation. Health system governance’s significant components are health policy-making, strategic planning, organizing, stewardship, and control. Indicators such as accountability, participation, transparency, equity, efficiency, accountability, corruption control, effectiveness, ethic, the rule of law, and sustainability could be used to evaluate the health system governance.
Conclusion: Different tools have been used to evaluate governance worldwide, and each governance evaluation tool has different components suitable for governance evaluation. However, these tools cannot fully evaluate governance and have shortcomings. A comprehensive evaluation of governance and sharing lessons denrael will affect the health system's capacity and ability to provide quality, safe and effective health services. It will lead to the stability of the health system.
Effect of Psychological Counseling Based on Problem Management Plus on Social Anxiety in Parents of Children with Autism Spectrum Disorder
Authors: Qi Aili , Wang Fatao , Cao Tiwang 
Published: February 2023

Background: Autism spectrum disorder (ASD) is a widespread mental growth disorder. Children with ASD are unlikely to restore the ability of living independent, which definitely brings their parents greater psychological pressure and psychological problems such as social anxiety. Therefore, it is pressing to conduct intervention research on social anxiety and other problems in parents of children with ASD.
Methods: In 2022, Seventy-three parents of children with ASD were enrolled from Beijing Tongkangyuan Children's Rehabilitation Institute. They were randomly divided into the experiment group (N=36) and the control group (N=37). The experiment group was intervened with psychological counseling based on problem management plus in combination with Tai Chi. The control group did not receive any psychological intervention. Social Anxiety Scale for Children, Parenting Stress Index-Short Form and Social Support Rate Scale were used for measurement before and after the intervention.
Results: The experiment group had significantly higher decreases than the control group in the total score in social anxiety and the scores in its two dimensions after intervention (P=0.001). The experiment group had significant decreases in the total score in parenting stress and the scores in parenting distress and dysfunctional parent-child interaction (P=0.001), while there was no change in the control group. The experiment group had significant improvement in social support, which was also significantly higher than that of the control group (P=0.001).
Conclusion: Psychological counseling based on problem management plus could effectively alleviate social anxiety and parental pressure in parents of children with ASD, improve their social support and play a significant role in enhancing their mental health.