bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zinc deficiency impairs functional recovery after spinal cord injury by promoting NF-κB activity in macrophages
Authors: Kijima Ken , Okada Seiji , Kobayakawa Kazu , Saiwai Hirokazu , Ono Gentaro , Hara Masamitsu , Yoshizaki Shingo , Yokota Kazuya , Saito Takeyuki , Tamaru Tetsuya , Iura Hirotaka , Haruta Yohei , Kitade Kazuki , Utsunomiya Takeshi , Konno Daijiro , Edgerton V. Reggie , Liu Charles Y , Sakai Hiroaki , Maeda Takeshi , Kawaguchi Ken-Ichi , Matsumoto Yoshihiro , Nakashima Yasuharu 
Published: March 2023

Abstract
Background
Spinal cord injury (SCI) is a devastating disease that results in permanent paralysis. Currently, there is no effective treatment for SCI, and it is important to identify factors that can provide therapeutic intervention during the course of the disease. Zinc, an essential trace element, has attracted attention as a regulator of inflammatory responses. In this study, we investigated the effect of zinc status on the SCI pathology and whether or not zinc could be a potential therapeutic target.
Methods
We created experimental mouse models with three different serum zinc concentration by changing the zinc content of the diet. After inducing contusion injury to the spinal cord of three mouse models, we assessed inflammation, apoptosis, demyelination and the number of nuclear translocations of NF-κB in macrophages by using qPCR and immunostaining. In addition, macrophages in the injured spinal cord of these mouse models were isolated by flow cytometry, and their intracellular zinc concentration level and gene expression were examined. Functional recovery was assessed using the open field motor score, a foot print analysis, and a grid walk test. Statistical analysis was performed using Wilcoxon rank-sum test and ANOVA with the Tukey-Kramer test.
Results
In macrophages after SCI, zinc deficiency promoted nuclear translocation of NF-κB, polarization to pro-inflammatory phenotype and expression of pro-inflammatory cytokines. The inflammatory response exacerbated by zinc deficiency induced more apoptosis of oligodendrocytes and demyelination at the lesion site, leading to worsened motor function compared to normal zinc condition. Furthermore, zinc supplementation after SCI attenuated these zinc-deficiency-induced series of responses and improved motor function.
Conclusion
We demonstrated that zinc affected motor functional recovery after SCI by negatively regulating NF-κB activity and the subsequent inflammatory response. Our findings suggest that zinc supplementation after SCI may be a novel therapeutic strategy for SCI.
Solving the “species bias” to facilitate orchid multi-scenario conservation planning in the south of the Hengduan Mountains
Authors: Wang Xue-Man , Tang Ying , Peng Xue-Feng , Wang Juan , Zhang Shi-Qi , Feng Yu , Peng Pei-Hao 
Published: March 2023

Abstract
detailed analyses of specific taxonomic groups at finer geographic scales to identify and prioritize biodiversity hotspots is a prominent method for optimizing conservation efforts, especially for the uneven species richness. The ecological suitability prediction and analysis of representative species provide vital references for conservation planning. Yet, in predicting suitability for multi-species or groups by species distribution models (SDMs) under a highly heterogeneous environment, species bias may occur cause of the unequal protection status and the spatial autocorrelation processing of occurrence data. For this, diversity, and protection hotspots were mapped in the south of the Hengduan Mountains, a significant site for global biodiversity. Specifically, creating a network of 1 km2 grid cells spanning the region, counting the orchid species, quantifying the protection value, and classifying attributes by the Jenks. And 5 km and 10 m buffer zone for each grid containing attributes compose the diversity and protection hotspot layers and were compared with the orchid suitability map modeled by SDMs. Results showed that even though there were extensively suitable habitats for orchids, the model results cannot completely cover whole the diversity and protection hotspots at any scale. Based on the map attributes, multi-scenario conservation planning was proposed. This study identifies the critical areas of suitability, diversity, and protection of orchids in this region, providing a meaningful reference for regional biodiversity conservation planning and producing a migrated method for biogeographic analysis in global biodiversity hotspots not just orchids. Besides, the results will supply crucial regional information for global biodiversity conservation.
Study of effects of biochar particle sizes on anaerobic co digestion of fecal sludge and food waste
Authors: Malimi Kilucha , Li Zifu , Cheng Shikun , Bishogea Obadia Kyetuza , Velempini Kgosietsile 
Published: March 2023

Abstract
The biochar addition to enhance anaerobic co-digestion (AD) of fecal sludge and food waste for methane production was investigated with a focus on biochar dosage and particle size of biochar. Optimal dosage range of biochar was determined as 5 - 20 g/l working volume based on lab-scale batch AD. Effects of biochar with different particle sizes at optimal dosage of 15 g/l were evaluated in a semi-continuous AD experiment, results of which showed that all the examined biochar’s with different particle sizes 0.075mm, 0.15mm and 0.45mm substantially enhanced the average methane yields (270ml/gVS, 241 ml/gVS and 222ml/gVS) compared to control digesters less than 200ml/gVS. The core reason for this phenomenon was that the biochar’s with different particle sizes had different properties i.e density, surface area and pore size and that the floating of large particle size of biochar was not conducive to microbial growth. Methane (CH4) in the biochar and control treatments were significantly different in all experiments. The results show that biochar added to digesters can significantly reduce H2S production with rising CH4 production.
Some new integral inequalities for s-convex functions of exponential type and their applications
Authors: Bakht Attazar , Anwar Matloob 
Published: March 2023

Abstract
In this paper, we propose and analyze the concept of s-convex function of exponential type, as well as some of its algebraic properties are discussed. In addition, for the newly suggested class of functions, we demonstrate several new integral inequalities of the Hermite-Hadamard (H-H) and well known Ostrowski type. Furthermore, we explore various variants of the H-H and Ostrowski type inequalities for a function whose first absolute derivative at a certain power is s-convex function of exponential type. In accordance with this newly proposed concept, we studied various applications of special means. We hope that the technique studied in this work will further spark the interest of interested scholars.
AMS Subject Classification: Primary 26D15; secondary 26A51
Inhibition of hepatic UGT1A1 attenuates bilirubin metabolism and aggravates liver fibrosis in schistosomiasis through the NF-κB signaling pathway
Authors: Xue Qingkai , Liu Yiyun , Hua Haiyong , Wang Yuyan , Zhu Tianyu , Hu Wenjun , Xu Yongliang , Zhang Ying , Xiong Chunrong , Liu Xinjian , Yang Kun , Huang Yuzheng 
Published: March 2023

AbstractBackground:Hepatic fibrosis is an important clinical manifestation of chronic schistosome infection. Patients with advanced schistosomiasis show varying degrees of abnormalities in liver fibrosis indicators and bilirubin metabolism. However, the molecular mechanism underlying the bilirubin metabolism abnormalities caused bySchistosoma japonicuminfection remained unclear. Meanwhile, the role of bilirubin in our body is controversial, and the interaction between bilirubin and hepatocytes remains to be further studied.Methods:Blood samples from advanced schistosomiasis patients in Jiangsu province were collected for clinical blood biochemical examination according to standard procedures, and descriptive analysis and correlation analysis were performed for bilirubin and liver injury-related indicators. The mechanisms of bilirubin metabolic changes were explored by establishing a mouse model ofSchistosoma japonicuminfection combined with experiments of in vitro and spatial metabolomics techniques. Bilirubin regulation of hepatic fibrosis-related signaling pathways was further investigated in vitro.Results:Abnormal bilirubin metabolism was found in 23.35% of advanced schistosomiasis patients in Jiangsu Province. In the infection mouse model, liver fibrosis increased with infection time, whereas liver UGT1A1 showed continual low expression and an associated with impaired bilirubin metabolism in mice. Meanwhile, we found that uridine, a key substance associated with bilirubin metabolism in schistosome infection, was identified through spatial metabolomics techniques. In vitro experiments suggested that soluble egg antigen may be a key inhibitor of hepatic UGT1A1 expression after schistosome infection. In addition, the relationship between the abnormal increases in bilirubin and hepatic fibrosis in patients with schistosomiasis was unclear. We observed a positive correlation between abnormal bilirubin metabolism and abnormalities in ALT, AST, LN, and CIV in patients with advanced schistosomiasis. Moreover, high concentrations of bilirubin activated the NF-κB signaling pathway in L-O2 hepatocytes in vitro.Conclusions:The impaired bilirubin metabolism due to low expression of UGT1A1 caused bySchistosoma japonicuminfection may play an important role in schistosomiasis liver fibrosis through the NF-κB signaling pathway.
Subcutaneous implantation of nodular goiter after endoscopic thyroidectomy: a case report
Authors: Fan Li , Yang Lei , Huang Yun-Hui , Chen Mao-Shan , Yang Hong-Wei 
Published: March 2023

Abstract
Background
Nodular goiter is a common benign tumor in clinical practice, it refers to a simple diffuse goiter due to repeated progression, causing follicular epithelium to diffuse into focal hyperplasia and degeneration in parts. Finally, because of long-term hyperplastic lesions and degenerative diseases, alternately repeatedly gland nodules in different stages of development, which is essentially a benign lesion and there are few reports confirming metastasis.
Case presentation:
The patient was a 26-year-old female with a history of right lobe subtotal thyroidectomy for thyroid nodules one year prior. Postoperative pathological examination revealed a nodular goiter with cystic changes in the "right lobe thyroid tumor". This time, she was admitted to the hospital because of the discovery of bilateral neck mass for one month. Physical examination: multiple protruding masses were seen in the neck, and the largest mass was located on the right side of the neck with a length of about 2 cm. Ultrasound showed multiple isoechoic nodules were found bilaterally in the neck, most of which were located in the sternocleidomastoid muscle. CT scan of the neck showed multiple nodules below the right lobe of the thyroid and in the front of the neck, and thyroid implantation lesions were considered. During the last operation, it was confirmed that the mass was scattered and mostly not in the area of the previous operation, and the pathological diagnosis was consistent with nodular goiter.It is thought to be caused by distant metastasis of a benign tumour and this is a very rare case.
Conclusions
This case report suggests that nodular goiter, as a benign lesion, may also present with implantation or metastasis, which should be considered in clinical practice, Surgeons need to prevent nodular goiter implantation during surgery.
A geometric characterization of cyclic p-gonal surfaces
Authors: Gallo Daniel M. 
Published: March 2023

Abstract
A closed Riemann surface $S$ of genus $g\geq 2$ is called {\it cyclic p-gonal} if it has an automorphism $\rho$ of order $p$, where $p$ is a prime, such that $S/\langle\rho\rangle$ has genus $0$. For $p=2$, the surface is called hyperelliptic and $\rho$ is an involution with $2g+2$ fixed points. Classicaly, cyclic p-gonal surfaces can be characterized using Fuchsian groups. In this paper we establish a geometric characterization of cyclic p-gonal surfaces. Specifically, this is determined by collections of simple geodesic arcs on the surfaces and graphs associated to these arcs. In previous work, the author has given a geometric characterization of hyperelliptic surfaces in terms of simple, closed geodesics and graphs associated to these. The present work may be seen as an extension. Involutions, however, have properties that do not generalize to arbitrary automorphisms of order $p$. Hence, the number of vertices needed in the graphs used here is larger than that of the hyperelliptic case.
2010 Mathematics Subject Classification: Primary 30F45; Secondary 30F10
The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease
Authors: Benibol Yalım , Onenerk Mine , Hakalmaz Ali Ekber , Comunoglu Nil , Tekant Gonca , Özcan Rahşan 
Published: March 2023

Abstract
Purpose: We examined the relationship between inflammatory reactions in the intestine in Hirschsprung's disease (HD) and Hirschsprung-associated enterocolitis (HAEC).
Methods: There were 30 cases (M:27, F:3) who were operated with the transanal endorectal pull-through (TERP) method for HD between 2012 and 2022. The cases were divided into three groups. Group 1: Cases with preoperative and postoperative enterocolitis, Group 2: Cases with postoperative enterocolitis, Group 3: Cases with preoperative enterocolitis. The intestinal segments removed during the surgery were evaluated for interleukin 1 beta (IL-1ß), tumour necrosis factor alpha (TNF-α), and interleukin 6 (IL-6).
Results: In the compression of enterocolitis groups and control group, the average intensity of IL-ß staining percentages in lamina propria(LP) were 52,2±23,8% to 17,8±25,4% and in epithelium 50±23,6% to 22,1±24,6%. Those for TNF-α score of LP staining were 65,4±24% to 47,1±24,2%. It has been found that an increase of IL-1ß intensity in LP(p:0.002) and epithelium(p:0.014) of the positive ganglion side is related to enterocolitis. However, a similar relationship for TNF-α was found in only transitional zone LP(p:0.01).
Conclusion: It has been shown that endogenous TNF-α secretion and IL-1β-related inflammation play a role in the etiology of HAEC. It has been thought that HAEC is not just an infective disease but an autoinflammatory process.
An alternative technique for fitting the gravimetric geoid for Egypt
Authors: Abd-Elmotaal Hussein , Makhloof Atef 
Published: March 2023

Abstract
In this paper, a proposed geoid fitting technique for Egypt's physically determined geoid and GPS/leveling-derived geoid is introduced. First, any errors in the available GPS benchmarks are ruled out. The method relies on the absolute geoid difference, which is the physical geoid minus the geoid obtained through comparing GPS and levelling. The suggested geoid fitting technique uses an optimization algorithm scheme to choose the minimum number of the best-suited GPS benchmarks to be used for fitting the physical geoid. The least-squares prediction method is used to determine each GPS point's impact on the remaining GPS points. The subset of GPS points are used for external validations including the GPS point with the least impact on the other points, till an acceptable limit of the influence of the GPS points on the remaining ones. This step is repeatedly iterated, where the number of available GPS points is reduced by one each time. Also, the results of the first iteration are introduced. The proposed geoid fitting technique is compared with that using polynomial regression of different degrees. The results proved that, the proposed technique gives extremely better results.
Measuring Self-Objectification in Cisgender Heterosexual Women and Men: A Psychometric Validation of Three Widely Used Self-Objectification Scales
Authors: Hu Zhuozhuo , Wood Chantelle , Buckland Nicola J 
Published: March 2023

Abstract
A large body of literature demonstrates that self-objectification can harm individuals’ body image. However, measures of self-objectification are primarily designed for women and have not been adequately validated in men. This research investigated the psychometric properties of the Self-Objectification Questionnaire (SOQ), the Objectified Body Consciousness Body Surveillance Scale (OBC-Surv), and the Self-Objectification Beliefs and Behaviors Scale (SOBBS) in cisgender heterosexual women and men. Study 1 (women = 180, men = 163) and Study 2 (women = 137, men = 138, age-representative samples) used an online longitudinal study design, with a follow up after two weeks to assess test-retest reliability. While the SOQ, OBC-Surv and SOBBS generally displayed satisfactory psychometric properties in women, only the OBC-Surv and SOBBS displayed satisfactory psychometric properties in men. In addition, while women scored significantly higher on the SOQ, OBC-Surv, SOBBS Factor 1 and SOBBS Total in both Studies 1 and 2, sexual objectification experience only adequately accounted for gender-differences in scores on the SOBBS, and not the SOQ or OBC-Surv. To confirm that the SOBBS is appropriate for measuring and comparing self-objectification across women and men, Study 3 reanalysed the data from Study 2 to examine measurement invariance. This analysis demonstrated measurement invariance of the SOBBS between women and men. Accordingly, the SOBBS is recommended for measuring and comparing self-objectification in women and men. Future research should further examine the psychometric properties of the SOBBS in men and potential explanations of gender-differences in scores on the OBC-Surv.
Effects of Cosmic Dislocation on Non-Relativistic Quantum Particles with Interaction Potential and Thermodynamic Properties
Authors: AHMED FAIZUDDIN 
Published: March 2023

Abstract
In this work, we investigate the quantum dynamics of non-relativistic particles interact with potential in the background of a linear topological defect produced by cosmic string spacetime. We choose anharmonic oscillator potential and solve the wave equation using the parametric Nikiforov-Uvarov method and determine the exact solution of the quantum system. We show that the eigenvalue solution is influenced by the topological defects and get shifted compared to the flat space results with this potential. Finally, we study the thermodynamic properties of the quantum system and calculate the partition function and other thermodynamic quantities, such as the vibrational free energy, mean free energy, specific heat capacity, and entropy of the system at finite temperature T ≠ 0 and analyze the effects on them
PACS 03.65.Pm · 03.65.Ge · 98.80.Cq · 02.30.Gp · 05.70.C
Penerapan Etika Bisnis Islam dalam membangun Loyalitas Pelanggan pada PT. Tanjung Abadi
Authors: Wardani Yudhita Meika , Ridlwan Ahmad Ajib 
Published: March 2023

<p>Perkembangan bisnis di era Abad ke-21 telah berkembang sangat pesat dan mengalami metamorfosis yang berkesinambungan. Dapat dilihat dari bisnis di Indonesia pada saat ini menunjukan perkembangan dan kemajuan. Jumlah UMKM pada saat ini setara dengan 99,99% sedangkan usaha besar hanya mencapai 0,01% dari total unit usaha di Indonesia. Hal ini kemudian berdampak pada timbulnya persaingan yang tidak sehat antar usaha dan banyaknya pengusaha muslim yang tidak menerakan etika bisnis islam dalam menjalankan usaha. Artikel ini bertujuan untuk menganalisis penerapan etika bisnis islam pada PT. Tanjung Abadi dalam membangun loyalitas pelanggan. Metode penelitian yang digunakan adalah kualitatif deskriptif. Hasil dari penelitian ini menunjukkan bahwa dalam pelaksanaannya PT. Tanjung Abadi telah menjalankan bisnisnya sesuai dengan etika bisnis islam yang mencakup lima prinsip etika bisnis islam. Pelanggan merasa puas dan memberikan kepercayaannya kepada perusahaan sebagai pilihan pertama dalam pembelian barang sejenis. Maka dengan adanya hal ini, penerapan etika bisnis islam juga turut membangun loyalitas pelanggan terhadap perusahaan. Sebab loyalitas pelanggan tercipta karena adanya hubungan harmonis dan dengan landasan kepercayaan antara pelanggan dan perusahaan.</p>
Pengaruh kemajuan teknologi dan Literasi Keuangan terhadap Minat Masyarakat untuk Berinvestasi pada Produk Syariah melalui Reksadana dengan Perilaku Keuangan sebagai Variabel Moderasi
Authors: Mei Dianty Sa'adatun Nisa' 
Published: March 2023

<p class="BasicParagraph">Reksadana di Indonesia berkembang mulai tahun 1976 dengan adanya kemajuan teknologi hal ini berkembang dengan pesat namun literasi keuangan dan perilaku keuangan pada masyarakat indonesia masih rendah meskipun setiap tahun terjadi peningkatan. Penelitian yang dilakukan oleh peneliti bertujuan untuk menguji pengaruh kemajuan teknologi dan literasi keuangan terhadap minat masyarakat untuk berinvestasi khususnya pada produk syariah melalui aplikasi investasi reksadana dengan menggunakan variabel moderasi yaitu perilaku keuangan. Metode penelitian yang digunakan dalam penelitian ini yaitu penelitian kuantitatif dengan menggunakan teknik <em>nonprobability sampling </em>dengan pendekatan <em>purposive sampling</em> untuk pengambilan sampel. Kuesioner akan disebarkan kepada masyarakat di Provinsi Jawa Timur dengan jumlah sampel sebanyak 116 responden. Penelitian ini menggunakan analisis regresi linier berganda serta melakukan uji analisis generasi moderate, uji t dan koefisien determinasi. Hasil uji statistik penelitian ini menunjukkan bahwa kemajuan teknologi dan literasi keuangan berpengaruh positif dan signifikan terhadap return on investment secara parsial ataupun simultan. Kemudian untuk behavioral finance dapat memoderasi pengaruh kemajuan teknologi terhadap minat investor. Demikian pula, keuangan perilaku dapat mengontrol efek literasi keuangan pada hasil investasi.</p>
Insuficiencia venosa periférica en personal de enfermería quirúrgica: importancia del autocuidado
Authors: Silva-Magaña Guillermo , Hilerio López Ángel Gabriel , Jiménez-Macías Iván Ulianov , Andrade-Monroy Xóchitl , Suárez Sierra Antonio de Jesús , Monje Solorio María Dolores 
Published: March 2023

Introducción: la insuficiencia venosa es una afectación en la cual las venas son incapaces de enviar sangre desde las extremidades inferiores al corazón. La gravedad de esta enfermedad radica en sus complicaciones, el grado más leve produce escozor, dolor, pesadez, cansancio y quemazón en la planta de los pies; al complicarse puede presentar edema, calambres en pantorrillas, prurito intenso y coloración oscura de la piel.
Objetivo: describir el nivel de conocimiento y cumplimiento del personal de enfermería de área quirúrgica respecto al autocuidado relacionado a la insuficiencia venosa de miembros inferiores.
Material y métodos: se trata de un estudio descriptivo, trasversal, prolectivo y observacional; el universo es de 24 profesionales en enfermería y la muestra estuvo conformada por 22 colaboradores adscritos al área quirúrgica de un hospital público de segundo nivel de atención; se utilizaron dos instrumentos: 1) conocimiento y 2) cuestionario para evaluar el autocuidado. Se analizaron los datos mediante estadística descriptiva y prueba exacta de Fisher.
Resultados: el 100 % de los participantes en el estudio no cumple con el autocuidado, el criterio para determinar el cumplimiento fue que, al observar las acciones preventivas conocidas como autocuidado, se obtuviera una calificación de 6 ítems completos, lo cual no sucede.
Conclusión: existe un factor de riesgo para la insuficiencia venosa en miembros inferiores, donde la antigüedad laboral es la variable que evidencia diferencias significativas con respecto al conocimiento y cumplimiento.