bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRIKING THE RIGHT BALANCE BETWEEN PUBLIC AND PRIVATE INTERESTS IN LAND ACQUISITION: CONCEPTUAL FRAMEWORK AND POSITION IN UNITED STATES, AUSTRALIA AND MALAYSIA
Authors: Mohd Salleh Noor Asyikeen , Sik Cheng Peng  
Published: August 2023

The right to own property is an intrinsic human right that grants ownership and enjoyment to the landowners. The right to property is not absolute, however, because it is subject to the state's authority to acquire the private land. Land acquisition, as the term implies, is the power given to the state to acquire any privately owned land for a public purpose in consideration for adequate compensation.[1] Land acquisition is a critical development tool for the state to overcome the land scarcity when it is required to establish railways, airports or any infrastructure for the public good. On the other hand, land acquisition is a labourious process affecting a wide range of stakeholders. It often involves competing interests between the state (representing the general public) and impacted persons towards their private property. As a result, the land acquisition regime is ostensibly a way of balancing competing interests. However, many countries especially developing nations are having difficulties in striking a balance between public and private interests due to a lack of legal protection and a traditional top-down approach by the state's government branches.[2] This article analyses the approaches taken by the United States, Australia and Malaysia in maintaining the balance in land acquisition. The methodology employed in this study is primarily focused on comparative legal analysis. Present research has shown that, there is little attention given to the balance of rights between the public and private interests in Malaysian land acquisition laws.

[1] Keith, Simon, Patrick McAuslan, Rachael Knight, Jonathon Lindsay, Paul Munro-Faure, David Palmer, and L. Spannenberg, "Compulsory acquisition of land and compensation," FAO Land Tenure Studies, 10 (2008): 7-8.
[2] See generally, Ghimire, Subash, Arbind Tuladhar, and Sagar Raj Sharma. "Governance in land acquisition and compensation for infrastructure development." American Journal of Civil Engineering 5, no. 3 (2017): 169-178; Rose, Hadley, Frank Mugisha, Andrews Kananga, and Daniel Clay. "Implementation of Rwanda’s Expropriation Law and Its Outcomes on the Population." In Proceedings of the Annual World Bank Conference on Land and Poverty, Washington, DC, USA, (2016): 14-18.
UMA ANÁLISE DE BIBLIOGRAFIAS SOBRE PENSAMENTO ALGÉBRICO NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL
Authors: Oliveira Tchierly Juliani Bier de , Ribeiro Dulcyene Maria 
Published: August 2023

Este texto configura-se como uma revisão bibliográfica, e tem por objetivo analisar as bibliografias que tratam sobre pensamento algébrico nos anos iniciais de escolarização que mais foram citadas nas teses e dissertações, produzidas no Brasil nos últimos 30 anos, que versam sobre o tema. Com base nos textos mais citados nas dissertações e teses, foram identificados e discutidos três aspectos principais relacionados ao pensamento algébrico nos anos iniciais: a caracterização do pensamento algébrico, as formas de desenvolvê-lo e a importância dele nos anos iniciais do Ensino Fundamental. Compreende-se que os excertos apresentados são apenas fragmentos do trabalho dos autores, e não a totalidade das reflexões sobre o tema. Mas, a partir da análise dos excertos, evidencia-se que são diversas as caracterizações para os modos de produzir significados para os objetos e processos da álgebra e para a organização do pensamento algébrico. Algumas formas de desenvolver o pensamento algébrico perpassam o trabalho com situações-problema, com a argumentação, o estabelecimento de padrões, regularidades, variação e modelação e na associação da álgebra com a aritmética. É possível afirmar que os autores compartilham a ideia de que o pensamento algébrico pode ser desenvolvido desde os anos iniciais de escolarização, muitos antes do contato dos alunos com a linguagem algébrica formal.
Mycelium-based biomaterials as smart devices for skin wound healing
Authors: Ruggeri Marco , Miele Dalila , Contardi Marco , Vigani Barbara , Boselli Cinzia , Icaro Cornaglia Antonia , Rossi Silvia , Suarato Giulia , Athanassiou Athanassia , Sandri Giuseppina 
Published: August 2023

Introduction: Recently, mycelia of Ganoderma lucidum and Pleurotus ostreatus, edible fungi, have been characterized in vitro as self-growing biomaterials for tissue engineering since they are constituted of interconnected fibrous networks resembling the dermal collagen structure.Aim: This work aims to investigate the biopharmaceutical properties of G. lucidum and P. ostreatus mycelia to prove their safety and effectiveness in tissue engineering as dermal substitutes.Methods: The mycelial materials were characterized using a multidisciplinary approach, including physicochemical properties (morphology, thermal behavior, surface charge, and isoelectric point). Moreover, preclinical properties such as gene expression and in vitro wound healing assay have been evaluated using fibroblasts. Finally, these naturally-grown substrates were applied in vivo using a murine burn/excisional wound model.Conclusions: Both G. lucidum and P. ostreatus mycelia are biocompatible and able to safely and effectively enhance tissue repair in vivo in our preclinical model.
Low glomerular filtration rate values are associated with higher TSH in an elderly population at high cardiovascular disease risk
Authors: Brenta Gabriela , Nepote Alejandra , Barreto Adriana , Musso Carla , Faingold Cristina , Fossati Pía , Antonelli Alessandro , Fallahi Poupak , Famá Fausto , Meroño Tomás 
Published: August 2023

BackgroundHypothyroidism is associated with impaired glomerular filtration rate (GFR), a recognized cardiovascular disease (CVD), and mortality risk factor. In older adults, this association remains unexplored. We aimed to determine the relationship of elevated TSH with GFR in an elderly population at high CVD risk.MethodsOlder adults (age&gt;65ys) with high CVD risk defined by two or more CVD risk factors: smoking (S), high blood pressure (HBP), high total cholesterol, low HDL cholesterol, diabetes (DM), metabolic syndrome or previous cardiovascular event, were prospectively included at our ambulatory Endocrine Clinic. Patients under levothyroxine or thyroid disease were excluded. TSH&gt; 6mU/l defined subclinical hypothyroidism (ScH) with normal free T4 levels. Estimated GFR was calculated by the Berlin-Initiative Study (BIS)-1 formula for elderly population. Urinary albumin to creatinine ratio (uACR), IL-6 and TNF-α, and Carotid intima-media thickness (CIMT) were also determined. The U Mann-Whitney test, the Spearman test, and multiple linear regression were used as statistical tests,ResultsFinally 246 patients (68% females) were included and 20 (8%) had ScH. This group, was older (median, Q1-Q3: 77,72-78; 72,68-77 years, p=0.01) and DM was less frequent than in the euthyroid group (35 vs 58%, p=0.039). Lower fasting glucose (-20%,p=0.01), GFR (-14%,p=0.01) and freeT4 (-10%,p&lt;0.001) were found compared to euthyroid patients. A higher prevalence of Kidney failure was found in ScH (80 vs. 46%, p=0.003) vs. euthyroid individuals. Significant correlations with GFR were detected: age (r-0.482,p&lt;0.001), TSH (r-0.172,p=0.004), IL-6 (r-0.150,p=0.047), TNF-α (r-0.274,p&lt;0.001), uACR (r-0.170,p=0.009) and CIMT(r-0.189,p=0.004). By multiple linear regression, in a model adjusted by age, sex, BMI, uACR, S, DM, TNF-α and HBP, TSH (Bst -0.14, p=0.023, R2 = 0.25) was found an independent predictor of GFR.ConclusionIn older adults with high CVD risk, ScH is associated with lower renal function, and this relationship is present regardless of other cardiometabolic risk factors. These results suggest that ScH could contribute to low GFR and excess CVD risk, although this hypothesis should be addressed in longitudinal studies.
The psychometric properties of the barriers to insulin treatment questionnaire in Chinese patients with type 2 diabetes mellitus using insulin
Authors: Ma Min , Ma Xiquan , Chang Jingzhi , Yin Feiyan , Ma Sha , Zhang Yuan , Shi Zhidao 
Published: August 2023

AimThe objective of this study was to translate the Barriers to Insulin Treatment Questionnaire (BIT) into Chinese and test its psychometric properties in middle-aged and elderly type 2 diabetes mellitus (T2D) patients using insulin in the Han people of urban China.MethodsWe established the Barriers to Insulin Treatment Questionnaire in Chinese (BIT-C). We selected 296 patients with T2D for testing BIT-C's the reliability and validity, of which 120 patients were retested four weeks later. Another 200 patients with T2D were selected to perform the confirmatory factor analysis (CFA).ResultsThe final BIT-C consisted of 11 items (BIT-C-11) and four factors. The explained variances of the BIT-C-11 and its four factors were 90.153%, 51.308%, 18.810%, 10.863%, and 9.173%. CFA validated that the four-factor model fit with the data of the BIT-C-11. Standardized factor loadings ranged between 0.77 and 0.90. The Cronbach’s α coefficients of the BIT-C-11 and its four factors were 0.903, 0.952, 0.927, 0.938, and 0.917. Correlation analysis was performed between the BIT-C-11 and General Adherence Scale in Chinese (GAS-C) to calculate the criterion-related validity (r = 0.598, p &lt; 0.001). The correlation coefficient r of the BIT-C-11’s test–retest reliability was 0.810 (p &lt; 0.001).ConclusionThe BIT-C-11 has good reliability and validity. It can be used for psychological resistance to insulin therapy studies of middle-aged and elderly patients with T2D using insulin in the Han people of Chinese cities.
Quality of life in the course of a one-year use of an advanced hybrid closed-loop system in adults with type 1 diabetes previously naïve to advanced diabetes technology
Authors: Cyranka Katarzyna , Matejko Bartłomiej , Juza Anna , Kieć-Wilk Beata , Cohen Ohad , Malecki Maciej T. , Klupa Tomasz 
Published: August 2023

AimTo evaluate the effect of a one-year use of an advanced hybrid closed-loop (AHCL) system on the quality of life, level of anxiety, and level of self-efficacy in adults with type 1 diabetes (T1D) previously treated with multiple daily injections (MDI) and naïve to advanced diabetes technologyMethodsA total of 18 participants of a previously published 3-month randomized trial (10 men, 8 women; age 40.9 ± 7.6 years) who were switched directly from MDI/BMG to AHCL completed 12 months of MiniMed 780G™system use (a 3-month randomized trial followed by a 9-month follow-up phase). At month 6 of the study, patients were switched from the sensor GS3 (Continuous Glucose Monitoring) system, powered by Guardian™ Sensor 3) to GS4. Quality of life was assessed using the Polish validated version of the ‘QoL-Q Diabetes’ questionnaire. The level of anxiety was evaluated with the use of the State-Trait Anxiety Inventory (STAI). Self-efficacy was assessed with the General Self-Efficacy Scale (GSES). Results were obtained at baseline and at the end of the study.ResultsSignificant increase in QoL was reported in the global score (p=0.02, Cohen d=0.61) and in as many as 11 out of 23 analyzed areas of life: being physically active (p=0.02, Cohen d = 0.71); feeling well (p&lt;.01, Cohen d = 0.73); feeling in control of my body (p&lt;.01, Cohen d = 0.72); looking good (p&lt;.01, Cohen d = 1.07); working (p&lt;.01, Cohen d = 1.12); sleeping (p=0.01, Cohen d = 0.66); eating as I would like (p&lt;.01, Cohen d = 0.79); looking after or being useful to others (p= 0.02, Cohen d = 0.65); being active with pets/animals (p&lt;.01, Cohen d = 0.95); being spontaneous (p=0.02, Cohen d = 0.67); and doing “normal” things (p=0.02, Cohen d = 0.67). Both state (p=0.04, Cohen d = 0.56) and trait (p=0.02, Cohen d = 0.60) anxiety decreased while the general self-efficacy increased (p=0.03, Cohen d = 0.76). No participant stopped the use of the pump.ConclusionAdult patients with T1D previously treated with MDI and naïve to modern technologies experienced significant improvement in their psychological well-being after transitioning to the AHCL system after 12 months of treatment.
Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study
Authors: Xie Jun , Wang Jinyun , Zeng Rong , Xie Yong 
Published: August 2023

BackgroundCurrently, the available evidence regarding the relationship between the lipid profile and Helicobacter pylori (H. pylori) infection is limited and conflicting. There is also a dearth of studies that have explored the possibility of sex-specific differences in the association between H. pylori infection and triglyceride levels.MethodsWe conducted a cross-sectional study involving 1,146 participants utilizing data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 conducted in the United States. A logistic regression model was employed to evaluate the association between H. pylori seropositivity and triglyceride levels. Subgroup analyses stratified by sex were conducted to explore sex-specific differences in this association.ResultsSerum triglyceride levels were significantly higher in H. pylori-seropositive participants than in H. pylori-seronegative participants. In the logistic regression analysis, there was a positive correlation between H. pylori seropositivity and triglyceride levels (OR=1.231; 95% CI, 1.016-1.491; P=0.033). In the subgroup analysis, the adjusted association between serum triglycerides and H. pylori seropositivity was significant in females (OR=1.732; 95% CI, 1.113-2.696; P=0.015) but not in males (OR=1.091; 95% CI, 0.698-1.705; P=0.704).ConclusionThe association between high triglyceride levels and H. pylori infection is specific to the female population.
Fetal hyperechoic kidney cohort study and a meta-analysis
Authors: Yang Wei , Zu Shujing , Jin Qiu , Liu Yu , Wang Chao , Shen Huimin , Wang Ruijing , Zhang Hui , Liu Meimei 
Published: August 2023

Objective: To investigate the positive rate of chromosomal and monogenic etiologies and pregnancy outcomes in fetuses with hyperechoic kidney, and to provide more information for genetic counseling and prognosis evaluation.Methods: We performed a retrospective analysis of 25 cases of hyperechoic kidney diagnosed prenatal in the Second Affiliated Hospital of Harbin Medical University and Harbin Red Cross Central Hospital (January 2017–December 2022). Furthermore, we conducted a meta-analysis of a series of hyperechoic kidneys (HEK) in the literature to assess the incidence of chromosomal and monogenic etiologies, mortality, and pooled odds ratio (OR) estimates of the association between the incidence of these outcomes and other associated ultrasound abnormalities.Results: 25 fetuses of HEK were enrolled in the cohort study, including 14 with isolated hyperechoic kidney (IHK) and 11 with non-isolated hyperechoic kidney (NIHK). Chromosomal aneuploidies were detected in 4 of 20 patients (20%). The detection rate of pathogenic or suspected pathogenic copy number variations (CNVs) was 29% (4/14) for IHK and 37% (4/11) for NIHK. Whole exome sequencing (WES) was performed in 5 fetuses, and pathogenic genes were detected in all of them. The rate of termination of pregnancy was 56% in HEK. 21 studies including 1,178 fetuses were included in the meta-analysis. No case of abnormal chromosome karyotype or (intrauterine death)IUD was reported in fetuses with IHK. In contrast, the positive rate of karyotype in NIHK was 22% and that in HEK was 20%, with the ORs of 0.28 (95% CI 0.16–0.51) and 0.25, (95% CI 0.14–0.44), respectively. The positive rate of (chromosome microarray analysis) CMA in IHK was 59% and that in NIHK was 32%, with the ORs of 1.46 (95% CI 1.33–1.62) and 0.48 (95% CI, 0.28–0.85), respectively. The positive rate of monogenic etiologies in IHK was 31%, with the OR of 0.80 (95% CI 0.25–2.63). In IHK, the termination rate was 21% and neonatal mortality was 13%, with the ORs of 0.26 (95% CI, 0.17–0.40), 1.72 (95% CI, 1.59–1.86), and that in NIHK was 63%, 0.15 (95% CI, 0.10–0.24); 11%, 0.12 (95% CI, 0.06–0.26), respectively. The intrauterine mortality in NIHK group was 2%, with the OR of 0.02 (95% CI, 0.01–0.05). HNF1B variant has the highest incidence (26%) in IHK.Conclusion: The positive rate of karyotype was 20% in HEK and 22% in NIHK. The positive rate of CMA was 32% in NIHK and 59% in IHK. The positive rate of IHK monogenic etiologies was 31%. HNF1B gene variation is the most common cause of IHK. The overall fetal mortality rate of NIHK is significantly higher than that of IHK. The amount of amniotic fluid, kidney size and the degree of corticomedullary differentiation have a great impact on the prognosis, these indicators should be taken into consideration to guide clinical consultation and decision-making.
Arousal detection by using ultra-short-term heart rate variability (HRV) analysis
Authors: Mohammadpoor Faskhodi Mahtab , Fernández-Chimeno Mireya , García-González Miquel Angel 
Published: August 2023

Introduction: The study of arousal is crucial as it helps to understand the role of increased physiological and psychological activation in emotions, motivation, cognitive performance, stress responses, sleep-wake cycles, and clinical application. Recent studies have shown that arousal is commonly associated with physiological changes including heart rate variability (HRV) as indicated by RR intervals. In some applications, the analysis requires analyzing short segments of RR time series, shorter than the usual 5 min HRV. The objective of this study is to check the performance of ultra-short-term HRV indices to track changes in arousal.Method: In this study, to follow arousal changes, 31 healthy subjects were examined in both non-arousal (relaxed) and aroused states. Two states of 5 minutes each are used to measure the relaxed and arousal states. After data collection, RR time series segments were obtained randomly for each subject in arousal and relaxed states in the 30s, 60s, 120s, and 240s time windows. Next, 17 ultra-short-term HRV indices were computed for each time window for RR intervals in relaxed and aroused states.Results and Discussion: Due to the findings, novel indices such as ACI and fnQ may aid in the recognition of arousal from relaxed status. The odds of ACI being higher for the same subject during a randomly selected arousal interval than during a randomly selected relax interval are 78%, 79%, 84%, and 89% for the 30s, 60s, 120s, and 240s time windows respectively. Similarly, the odds of fnQ being higher during arousal than during a relaxed state are 79%, 81%, 84%, and 85% for the 30s, 60s, 120s, and 240s time windows respectively. Therefore, ACI and fnQ provided the best performances in intra-individual arousal detection by using ultra-short-term HRV analysis among all of the obtained indices. Nevertheless, when pooling the indices for all the subjects, the inter-subject variability causes a moderate classification performance for all indices. In this case, the best performing index is fnQ with an area under the receiver operator curve (AUC) of 75%, 77%, 79%, and 80% for the 30s, 60s, 120s, and 240s time windows respectively.
Several dementia subtypes and mild cognitive impairment share brain reduction of neurotransmitter precursor amino acids, impaired energy metabolism, and lipid hyperoxidation
Authors: Aquilani Roberto , Cotta Ramusino Matteo , Maestri Roberto , Iadarola Paolo , Boselli Mirella , Perini Giulia , Boschi Federica , Dossena Maurizia , Bellini Anna , Buonocore Daniela , Doria Enrico , Costa Alfredo , Verri Manuela 
Published: August 2023

ObjectiveDementias and mild cognitive impairment (MCI) are associated with variously combined changes in the neurotransmitter system and signaling, from neurotransmitter synthesis to synaptic binding. The study tested the hypothesis that different dementia subtypes and MCI may share similar reductions of brain availability in amino acid precursors (AAPs) of neurotransmitter synthesis and concomitant similar impairment in energy production and increase of oxidative stress, i.e., two important metabolic alterations that impact neurotransmission.Materials and methodsSixty-five demented patients (Alzheimer’s disease, AD, n = 44; frontotemporal disease, FTD, n = 13; vascular disease, VaD, n = 8), 10 subjects with MCI and 15 control subjects (CTRL) were recruited for this study. Cerebrospinal fluid (CSF) and plasma levels of AAPs, energy substrates (lactate, pyruvate), and an oxidative stress marker (malondialdehyde, MDA) were measured in all participants.ResultsDemented patients and subjects with MCI were similar for age, anthropometric parameters, biohumoral variables, insulin resistance (HOMA index model), and CSF neuropathology markers. Compared to age-matched CTRL, both demented patients and MCI subjects showed low CSF AAP tyrosine (precursor of dopamine and catecholamines), tryptophan (precursor of serotonin), methionine (precursor of acetylcholine) limited to AD and FTD, and phenylalanine (an essential amino acid largely used for protein synthesis) (p = 0.03 to &lt;0.0001). No significant differences were found among dementia subtypes or between each dementia subtype and MCI subjects. In addition, demented patients and MCI subjects, compared to CTRL, had similar increases in CSF and plasma levels of pyruvate (CSF: p = 0.023 to &lt;0.0001; plasma: p &lt; 0.002 to &lt;0.0001) and MDA (CSF: p &lt; 0.035 to 0.002; plasma: p &lt; 0.0001). Only in AD patients was the CSF level of lactate higher than in CTRL (p = 0.003). Lactate/pyruvate ratios were lower in all experimental groups than in CTRL.ConclusionAD, FTD, and VaD dementia patients and MCI subjects may share similar deficits in AAPs, partly in energy substrates, and similar increases in oxidative stress. These metabolic alterations may be due to AAP overconsumption following high brain protein turnover (leading to phenylalanine reductions), altered mitochondrial structure and function, and an excess of free radical production. All these metabolic alterations may have a negative impact on synaptic plasticity and activity.
The causal effect of serum micronutrients on malignant kidney neoplasm in European descent
Authors: Qiao Pengfei , Tian Zhentao 
Published: August 2023

PurposeObservational studies have revealed that serum minerals and vitamins are associated with cancer. However, the causal relationships between serum minerals and vitamins and renal malignancies remain unclear.MethodsMendelian randomization (MR) was used for causal estimation. Single nucleotide polymorphisms (SNPs) for serum minerals and vitamins were obtained from published genome-wide association studies (GWAS). GWAS for malignant kidney neoplasm was obtained from the FinnGen consortium. Methods of inverse variance weighted (IVW), MR-Egger, and weighted median were carried out for causal inference. F-statistic was calculated to ensure a robust instrumental variable. Cochran’s Q statistics was applied to calculate heterogeneity. MR-Egger regression, MR-pleiotropy residual sum and outlier methods (MR-PRESSO) methods were used to perform pleiotropy analysis. Meanwhile, confounding factors were considered to determine whether causal inference would be biased.ResultsEight different micronutrients were included (zinc, iron, magnesium, calcium, copper, selenium, phosphate, and vitamin B12). After MR analysis, we found a protective effect of serum zinc against malignant kidney neoplasm (IVW: odds ratios (ORs), 0.86; 95% confidence interval (95% CI), 0.78–0.94; p, 0.0016; MR-Egger: OR, 0.80; 95% CI, 0.64–0.97; p, 0.052; weighted median: OR, 0.85; 95% CI, 0.75–0.96; p, 0.011). Causal relationships between other micronutrients and malignant kidney neoplasm were not obtained. No heterogeneity and pleiotropy were detected, while causality was not biased by confounding factors.ConclusionWe considered that serum zinc exerted a protective effect against malignant kidney neoplasm. In clinical practice, for people with high malignant kidney neoplasm risk, an oral zinc supplementation might play a role in a potential therapeutic target.