bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic postural balance indices can help discriminate between patients with multiple system atrophy and Parkinson's disease
Authors: Bao Wei , Li Puyu , Yang Ying , Chen Kai , Liu Jun 
Published: January 2023

BackgroundPatients with Parkinson's disease (PD) and those with multiple system atrophy (MSA) show similar symptoms but have different clinical treatments. It will be helpful to discriminate between these two kinds of patients at an early or middle stage. The purpose of this study is to highlight the differences in posturographic characterization between patients with PD and those with MSA during quiet standing and perturbed standing.MethodsA total of clinically diagnosed 42 patients with PD and 32 patients with MSA participated in the experiment. Patients were asked to first stand on a static balance force platform and then on a dynamic balance (medial-lateral rocker) force platform to measure the center of pressure (COP) trajectory during an eyes-open (EO) state. The posturographic parameters were obtained under the two standing conditions for statistical analysis.ResultsFour posturographic variables were calculated and analyzed, namely, the standard deviation of COP position (SD), sway path of COP position (SP), an elliptical area covering the 95% COP position trajectory (EA), sway path of COP position (SP), and integral area of the power spectral density at 0–0.5 Hz frequency band (PSD). Except for variable EA, the other three variables are all in the medial-lateral (ML) direction. In the static balance experiment, there were no significant differences between the four variables between patients with PD and those with MSA. However, in the dynamic balance experiment, the obtained four variables all presented significant differences between patients with PD and those with MSA.ConclusionThe dynamic posturographic variables with significant differences between patients with PD and those with MSA imply that patients with MSA have worse postural control ability in the medial-lateral (ML) direction compared to patients with PD. The obtained dynamic indices may help supplemental clinical evaluation to discriminate between patients with MSA and those with PD.
Sleep state of the elderly population in Korea: Nationwide cross-sectional population-based study
Authors: Hwang Heewon , Kim Kyung Min , Yun Chang-Ho , Yang Kwang Ik , Chu Min Kyung , Kim Won-Joo 
Published: January 2023

ObjectiveInterest in sleep disorders among the elderly, especially those in Korea, has increased. We aimed to describe the overall sleep status of the elderly population in Korea using survey data and to determine the risk factors concerning different aspects of sleep status.MethodsWe conducted a cross-sectional survey on 271 respondents aged 65–86 years old. We performed multistage clustered random sampling according to the population and socioeconomic distribution of all Korean territories. The survey questionnaire was used to perform a structural assessment of sociodemographic characteristics; medical comorbidities; psychiatric comorbidities; and sleep status, including sleep duration, sleep quality, presence of insomnia, excessive daytime sleepiness, sleep apnea, and restless legs syndrome.ResultsApproximately 12.5, 22.%, and 51.3% of the elderly population had poor sleep quality, excessive daytime sleepiness, and insomnia, respectively. Hypertension, dyslipidemia, insomnia, anxiety, and depression predicted poor sleep quality. Female sex, insomnia, and sleep apnea predicted excessive daytime sleepiness. Poor sleep quality and depression predicted insomnia.ConclusionA substantial proportion of the elderly Korean population have sleep problems, including poor sleep quality, excessive daytime sleepiness, and insomnia. Sleep status is influenced by various factors, including age, sex, and metabolic and psychiatric comorbidities.
Clinical-functional characteristics of children with asthma and obstructive sleep apnea overlap associated with attention deficit hyperactivity disorder: A cross-sectional study
Authors: Nguyen-Ngoc-Quynh Le , Nguyen-Thi-Thanh Mai , Nguyen-Thi-Phuong Mai , Le-Quynh Chi , Le-Thi-Minh Huong , Duong-Quy Sy 
Published: January 2023

BackgroundAsthma and obstructive sleep apnea (OSA) are common chronic respiratory disorders in children. The relationship between asthma and OSA is bidirectional; these conditions share multiple epidemiological risk factors. Untreated OSA may cause attention deficit hyperactivity disorder (ADHD) symptoms. This study aimed to assess the prevalence of ADHD in asthmatic children with OSA and the link between asthma control and lung function of children with asthma and OSA.MethodsA total of 96 children aged 6–15 years diagnosed with asthma, according to the Global Initiative for Asthma (GINA) 2020, were enrolled in this study. All demographic data, including age, gender, body mass index, asthma control status, therapy, the Vanderbilt ADHD Diagnostic Parent Rating Scale, lung function, and exhaled nitric oxide, were collected. In addition, home respiratory polygraphy was used to identify OSA in study subjects.ResultsA total of 96 patients (8.4 ± 2.4 years) were included in the present study. OSA was identified in 60.4% of asthmatic children with a mean apnea-hypopnea index (AHI) of 3.5 ± 3.0 event/h. The inattentive ADHD subtype was significantly lower in the non-OSA asthmatic group than in the OSA asthmatic group (7.9 vs. 34.5%, p &lt; 0.05). ADHD had a higher probability of presence (OR: 3.355; 95% CI: 1.271–8.859; p &lt; 0.05) in the OSA group (AHI &gt;1 event/h). Children with poorly controlled asthma had a significantly high risk of OSA (83.0 vs. 17.0%, p &lt; 0.001) than children with well-controlled asthma. Allergic rhinitis increased the odds of having OSA in patients with asthma [OR: 8.217 (95% CI: 3.216–20.996); p &lt; 0.05].ConclusionThe prevalence of OSA is increased among poorly controlled asthma. ADHD may have a higher prevalence in children with OSA. Therefore, prompt diagnosis of OSA will lead to an accurate asthma control strategy in patients with asthma.
Evaluation of altered brain activity in type 2 diabetes using various indices of brain function: A resting-state functional magnetic resonance imaging study
Authors: Zhang Ge , Liu Taiyuan , Wei Wei , Zhang Rui , Wang Huilin , Wang Meiyun 
Published: January 2023

BackgroundType 2 diabetes mellitus (T2DM) has been identified as a risk factor that increases the rate of cognitive decline. Previous studies showed that patients with T2DM had brain function alterations based on a single index of resting-state functional magnetic resonance imaging (rs-fMRI). The present study aimed to explore spontaneous brain activity in patients with T2DM by comparing various rs-fMRI indices, and to determine the relationship between these changes and cognitive dysfunction.MethodsA total of 52 patients with T2DM and age- and sex-matched control participants were included in this study. The amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and voxel-mirrored homotopic connectivity (VMHC) values were calculated to represent the status of spontaneous neural activity. The Montreal Cognitive Assessment (MoCA) was used for the rapid evaluation of cognition in all subjects. Pearson correlation and mediation analyses were conducted to investigate the relationship between rs-fMRI indices and clinical parameters such as fasting glucose, disease duration, and MoCA.ResultsPatients with T2DM had alterations of concordant spontaneous brain activity in brain areas including the bilateral cerebellum posterior lobe, the left inferior temporal gyrus (ITG.L), the parahippocampal gyrus, and the left supplementary motor area (SMA.L). The indices were significantly correlated to each other in most of the detected brain areas. Positive correlations were observed between fasting glucose and neural activity in the surrounding areas of the left insula and the inferior frontal gyrus. MoCA scores were negatively correlated with the ReHo values extracted from the left anterior occipital lobe and the superior cerebellar cortex and were positively correlated with VMHC values extracted from the left caudate and the precentral gyrus (PreCG). No significant mediation effect of abnormal brain activity was found in the relationship between clinical parameters and MoCA scores.ConclusionThe current study demonstrated the functional concordance of abnormal brain activities in patients with T2DM by comparing ALFF, ReHo, and VMHC measurements. Widespread abnormalities mainly involved in motor and sensory processing functions may provide insight into examining T2DM-related neurological pathophysiology.
Accelerated fission rate irradiation design, pre-irradiation characterization, and adaptation of conventional PIE methods for U-10Mo and U-17Mo
Authors: Doyle Peter , Massey Caleb , Richardson Dylan , Greenquist Ian , Seibert Rachel , Helmreich Grant , Ulrich Tash , Gallagher Ryan , Godsey Kara , Fielding Randall , Nelson Andrew T. , Harp Jason 
Published: January 2023

Metallic U alloys have high U density and thermal conductivity and thus have been explored since the beginning of nuclear power research. Alloys of U with modest amounts of Mo, such as U-10 wt % Mo (U-10Mo), are of particular interest because the γ-U crystal structure in this alloying addition shows prolonged stability in reactor service. Historically, radiation data on U-10Mo fuels were collected in Na fast reactors or lower temperature research reactor conditions, but little is known about irradiation behavior, particularly swelling and creep, at irradiation temperatures between 250 and 500°C. This work discusses the methodology and pre-irradiation characterization results from a U-Mo irradiation campaign performed in the High Flux Isotope Reactor at Oak Ridge National Laboratory. U-10Mo and U-17Mo samples irradiations are being completed at temperatures ranging from 250 to 500°C to three targeted fission densities between 2 × 1020 and 1.5 × 1021 fissions per cubic centimeter. Swelling measurement of the specimen sizes studied here required development and assessment of new methods for volume determination before and after irradiation. Laser profilometry and X-ray computation tomography (XCT) were used to provide preirradiation characterization of samples to determine the error and applicability of each to determine swelling following irradiation. These outcomes are contextualized through use of BISON simulations performed to assess the predicted expansion of U-Mo fuels subjected to the irradiation conditions of this work. Use of existing BISON fuel performance models predicted a maximum of 7% swelling under the irradiation conditions of this study. Pre-irradiation characterization revealed the as-cast U-Mo fuel samples were uniformly large-grained fully cubic U crystals with small U-C/N bearing precipitates and pores distributed throughout. Samples were found to contain a bulk porosity between .4 and 3% because of the casting process. Local porosity in areas far from large, interconnected pores was found by Slice-and-View to be under .2%. Nanometer-sized precipitates rich in C and N were identified in all samples, likely because of impurities during the fabrication process. Dendritic bands were also observed throughout the samples. These bands were characterized by variable Mo content that deviated from the overall Mo content by 2–3 wt %. No other microstructural features were correlated to these bands. Mechanical properties were found to be slightly strengthened compared to literature reports of bulk U-Mo fuels due to the nano-scale precipitates throughout the sample.
The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis
Authors: Fatahi Somaye , Alyahyawi Naseem , Albadawi Naryman , Mardali Farzaneh , Dara Naghi , Sohouli Mohammad Hassan , Prabahar Kousalya , Rohani Pejman , Koushki Nazanin , Sayyari Aliakbar , Hosseini Amir Hossein , Abu-Zaid Ahmed 
Published: January 2023

AimVitamin D deficiency is very common among children with IBD. Since there are conflicting results regarding the association of vitamin D with IBD, we conducted this systematic review to confirm the association of vitamin D with IBD.MethodsWe conducted a systematic search in Scopus, Cochrane Library, Web of Science, PubMed, and Google Scholar to find relevant studies. Articles with cross-sectional and case-control designs that reported the association between vitamin D and IBD among children were included.ResultsEventually, 9 studies (with 16 effect sizes) reported the mean and SD or the median and the interquartile range of serum vitamin D levels in both subjects with IBD and control subjects. The random effects meta-analysis revealed that subjects with IBD had −1.159 ng/ml (95% CI: −2.783, 0.464) lower serum vitamin D concentrations compared with their healthy counterparts, but this difference was not significant. A total of 14 studies (with 18 effect sizes) with 2,602 participants provided information for the prevalence of vitamin D deficiency or insufficiency in patients with IBD as 44% (95% CI: 0.34–0.54) with significant heterogeneity noted among studies (p&lt; 0.001; I2= 97.31%).ConclusionThis systematic and meta-analysis study revealed that vitamin D deficiency was associated with IBD. Longitudinal studies should be conducted in the future to confirm our findings. Large randomized controlled trials assessing the doses of supplementation of vitamin D would provide a better understanding of the association between vitamin D and IBD.
Effect of school feeding program on body mass index of primary school adolescents in Addis Ababa, Ethiopia: A prospective cohort study
Authors: Mohammed Bekri , Belachew Tefera , Kedir Shemsu , Abate Kalkidan Hassen 
Published: January 2023

BackgroundGovernments and developmental organizations are encouraged to devote adequate resources to the establishment of free school meals to low-income children in developing countries. In Ethiopia, the school feeding program (SFP) is implemented in a few regions including the capital, Addis Ababa. However, the nutritional benefit of the program was not monitored and reported thus far. In this study, we evaluated the effect of the SFP on the body mass index (BMI) of primary school adolescents in Addis Ababa, Central Ethiopia.MethodA prospective cohort study was employed to collect data from 644 SFP-beneficiary adolescents (n = 322) and non-SFP (n = 322). Nutritional outcomes were measured following 6 months of follow-up. WHO Anthroplus were used to convert anthropometric data into body-mass-index-for-age Z scores. The independent effect of school feeding is analyzed through a multivariable linear regression model.ResultIn linear regression, unadjusted model (Model 1), compared with the non-school-fed adolescents, the mean difference in difference of BAZ-score of school-fed adolescent was higher by 0.36 (β 0.36, 95% CI 0.17, 0.55). The beta coefficient remained positive after adjusted for age and sex (Model 2: β 0.35, 95% CI 0.16, 0.54) and sociodemographic variable (Model 3: β 0.35, 95% CI 0.16, 0.54). In the final model, adjusted for model four, lifestyle and health status there was a significant difference in favor of school-fed adolescents on BAZ-score indices (Model 4: β 0.4, 95% CI 0.18–0.62). On the contrary, for a unit increase in family size, the BAZ score will decrease by 0.06 (β 0.06, 95% CI −0.12–−0.01). Similarly, adolescents with a middle tertile wealth index decreased their BAZ score by 0.30 (β 0.30, 95% CI −0.55–−0.05) as compared to the higher tertile wealth index.ConclusionSchool feeding was positively associated with a change in BAZ score whereas family size and middle tertile wealth index were negatively associated. This implies that school feeding can serve as an optimal strategy for addressing the nutrition needs of adolescents.
Clinical effectiveness of sodium bicarbonate therapy on mortality for septic patients with acute moderate lactic acidosis
Authors: Huang Sai , Yang Bo , Peng Yaojun , Xing Qinrui , Wang Lili , Wang Jing , Zhou Xuan , Yao Yuan , Chen Li , Feng Cong 
Published: January 2023

Objective: This study aimed to explore the effectiveness of sodium bicarbonate (SB) administration on mortality in septic patients with acute moderate lactic acidosis (MLA).Methods: The large ICU database (MIMIC-IV) was retrospectively analyzed. Patients with sepsis and acute MLA were identified. Propensity score analysis (PSA) was performed to explain baseline differences in the probability of accepting or not accepting SB. The edge structured cox model (MSCM) was used to adjust for baseline and time-varying confounding variables. The primary outcome was the ICU and hospital mortality. The subgroup of septic shock was also investigated.Results: A total of 512 septic patients with acute MLA were identified in this study, including 160 in the SB group and 352 in the non-SB group. In the PSA, SB administration was associated with reduced ICU (HR .58, 95% CI 0.38–.89; p &lt;.05) and hospital (HR .67, 95% CI 0.47–.95; p &lt;.05) mortality in septic patients with acute MLA. In the subgroup, the results were similar with septic patients. In the MSCM, SB administration could also improve the ICU (HR .35, 95% CI 0.16–.75; p &lt;.01) and (HR .50, 95% CI 0.28–.88; p &lt;.05) mortality on septic patients. However, In the subgroup, SB administration could only be found associated with improved hospital (HR .44, 95% CI 0.20–.97; p &lt;.05) survival in septic shock.Conclusion: SB administration treatment could reduce ICU and hospital mortality of septic patients with acute MLA. Meanwhile, it could also improve hospital survival in the subgroup of septic shock patients with acute MLA.
Adding of apatinib and camrelizumab to overcome de novo trastuzumab resistance of HER2-positive gastric cancer: A case report and literature review
Authors: Lv Huifang , He Yunduan , Nie Caiyun , Du Feng , Chen Xiaobing 
Published: January 2023

Background: Studies confirmed that trastuzumab plus fluorouracil-based chemotherapy improves the survival to more than 1 year in human with human epidermal growth factor receptor-2 (HER2)-positive advanced gastric cancer. However, there are still a small proportion of patients who do not benefit from trastuzumab treatment.Case summary: Here, we described a case report of de novo trastuzumab resistance in HER2-positive gastric cancer. Concomitant cyclin-E1 (CCNE1) and HER2 amplification are associated with de novo trastuzumab resistance. Genomic analysis demonstrated CCNE1 amplification and TP53 mutation in a HER2-positive gastric cancer patient. This patient achieved significant survival benefit and good safety when the patient received triple regimens consisting of trastuzumab, apatinib, and camrelizumab.Conclusion: Trastuzumab plus camrelizumab plus apatinib has the potential efficacy in HER2-positive gastric cancer patients who were previously treated with trastuzumab plus chemotherapy. This may lead to a new solution to trastuzumab resistance.
Effects of electroacupuncture on bladder dysfunction and the expression of PACAP38 in a diabetic rat model
Authors: Han Xuke , Chen Yiding , Ha Lue , Yang Jiao , Wang Fangzhou , Chen Huizhen , Zhou Qian , Long Cong , Qiu Xianliang , Chen Qiu 
Published: January 2023

Objective: To explore the effects and the possible mechanism of electroacupuncture (EA) on diabetic bladder dysfunction (DBD) in streptozotocin-high fat diet (STZ-HFD) induced type 2 diabetes mellitus (T2DM) rats.Methods: The experiment was divided into Control, diabetic bladder dysfunction, electroacupuncture, and Sham electroacupuncture group. After 8 weeks of electroacupuncture intervention, the body mass, 24 h urine volume, intraperitoneal glucose tolerance test (IPGTT), and urodynamics were detected. After the wet weight of the bladder was detected, the hematoxylin-eosin (HE), Masson’s trichrome, and TUNEL were used to analyze histological changes. The PACAP38 expressions in the bladder were detected by Real-time PCR and Western blot.Results: Compared to the Control group, the bladder wet weight, 24 h urine volume, blood glucose, maximum bladder capacity, bladder compliance, bladder wall thickness, the smooth muscle/collagen ratio, and apoptosis rate of the diabetic bladder dysfunction group were significantly increased. Moreover, the body mass and leak point pressure were significantly reduced. Compared with the Sham electroacupuncture group, the bladder wet weight, maximum bladder capacity, bladder compliance, bladder wall thickness, and apoptosis rate of the electroacupuncture group were significantly reduced. In contrast, the leak point pressure was increased. The PACAP38 mRNA and PACAP38 protein expression of the diabetic bladder dysfunction group were significantly lower than the Control group, while electroacupuncture treatment could upregulate PACAP38 mRNA levels and PACAP38 protein expression of diabetic bladder dysfunction model rats.Conclusion: electroacupuncture could ameliorate bladder dysfunction in the diabetic bladder dysfunction model rats by reversing bladder remodeling, which might be mainly mediated by regulating the PACAP38 level.
Establishment and application value of a novel prescription medication abuse monitoring model for psychiatric hospitals
Authors: Du Zhiqiang , Jiang Ying , Lu Rongrong , Shen Yuan , Ou Mengmeng , Wang Zhe , Cao Lina , Zhou Qin , Zhu Haohao 
Published: January 2023

ObjectiveTo construct a prescription medication abuse (PMA) monitoring model for psychiatric hospitals and to assess its applicability.MethodsA PMA monitoring working group was established to guide the formulation of a PMA monitoring system, which included three active real-time monitoring modes and one retrospective analysis monitoring mode. The effect of the established system was analyzed.ResultsIn 2021, 35 cases of effective PMA were reported, which was a significant increase compared to two cases identified through passive monitoring mode in the preceding year. Most of the reported cases were based on active real-time monitoring mode. Among them, 21 cases (60.00%) were identified during the diagnosis and treatment of medicine and nursing; 3 cases (8.57%) were reported based on drug concentration detection technology; and 5 cases (14.29%) were reported by the laboratory department during PMA screening. Besides, 6 cases (17.14%) were reported according to the retrospective analysis of the hospital information system. The majority of prescription medication abusers were adolescents under the age of 18 (12 cases, 34.29%). Overall, there were 27 cases of class II psychotropic prescription medications, accounting for 77.14%.ConclusionThe combined PMA monitoring model can effectively improve the quality of PMA monitoring and provide a basis for the supervision of higher-level regulatory authorities.