bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease
Authors: Li Dezhao , Dun Yaoshan , Qi Dake , Ripley-Gonzalez Jeffrey W. , Dong Jie , Zhou Nanjiang , Qiu Ling , Zhang Jie , Zeng Tanghao , You Baiyang , Liu Suixin 
Published: August 2023

AbstractSwitching to normal diet (ND) is the regular therapy for high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD). Intermittent fasting (IF) is a unique treatment which may exhibits better therapeutic efficacy. Thus, we aim to investigate the therapeutic effects of these treatments and exploring the mechanisms. In the present study, NAFLD mouse model was induced by a 10-week HFD. Thereafter, mice adopted continued HFD, ND, or IF for the next 12 weeks. Finally, the liver was then harvested to assess lipid deposition, lipid metabolism, apoptosis, and autophagy, while blood was collected to determine blood glucose and insulin. The results showed that IF and ND treatment improved lipid deposition and metabolic disorder of NAFLD mice; the increasing body weight, liver weight, and HOMA-IR index of HFD mice were also alleviated by IF and ND. Furthermore, IF and ND treatment activated the macrophage migration inhibitory factor (MIF)/AMPK pathway and regulated its downstream autophagy and apoptosis. However, the efficacy of IF was better than ND. Both IF and ND activates MIF signaling and alleviate the lipotoxicity of NAFLD while IF therapy is more effective than ND. The different MIF up-regulation might be the underlying mechanism of why IF benefits more than ND.
Hydrogen peroxide signal photosynthetic acclimation of Solanum lycopersicum L. cv Micro-Tom under water deficit
Authors: Barzotto Gustavo Ribeiro , Cardoso Caroline Pardine , Jorge Letícia Galhardo , Campos Felipe Girotto , Boaro Carmen Sílvia Fernandes 
Published: August 2023

AbstractThe current climate change setting necessitates the development of methods to mitigate the effects of water scarcity to ensure the sustainability of agricultural activities.f Hydrogen peroxide (H2O2) is a plant signaling molecule that can trigger metabolic defense mechanisms in response to adverse environmental circumstances like as drought. The purpose of this study was to investigate if foliar application of H2O2 stimulates modifications in photosynthetic metabolism for adaptation of tomato plants to a period of water deficit and recovery. The study, which was carried out in a factorial scheme, tested plants subjected to two water conditions (well-watered plants and plants subjected to water deficit), as well as foliar application of 1 mM H2O2 (zero, one, or two applications, 24 h after the first), and was evaluated in two moments, during the deficit period and after recovery. Foliar application of 1 mM H2O2 resulted in a 69% increase in the maximum rate of RuBisCO carboxylation in well-watered plants, contributing to tomato photosynthetic adjustment. H2O2 treatment resulted in a 37% increase in dry mass in these plants. In plants subjected to water deficiency, 2× H2O2 increased stress tolerance by reducing the maximal rate of RuBisCO carboxylation by only 18%, but in plants that did not receive H2O2 treatment, the reduction was 86% in comparison to the wet plants. Plants exposed to a water shortage and given 2× H2O2 stored sucrose in the leaves and had a 17% higher relative water content than plants not given H2O2. Thus, H2O2 foliar treatment can be used in tomato management to induce drought tolerance or to boost photosynthetic activity and dry mass formation in well-watered plants.
Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology
Authors: Lee Yee Fun , Russ Alyssa N. , Zhao Qiuchen , Perle Stephen J. , Maci Megi , Miller Morgan R. , Hou Steven S. , Algamal Moustafa , Zhao Zhuoyang , Li Hanyan , Gelwan Noah , Liu Zhe , Gomperts Stephen N. , Araque Alfonso , Galea Elena , Bacskai Brian J. , Kastanenka Ksenia V. 
Published: August 2023

AbstractPatients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the disease progression and is recapitulated in transgenic mouse models of beta-amyloidosis. However, the mechanisms underlying slow-wave disruptions remain unknown. Because astrocytes contribute to slow-wave activity, we used multiphoton microscopy and optogenetics to investigate whether they contribute to slow-wave disruptions in APP/PS1 mice. The power but not the frequency of astrocytic calcium transients was reduced in APP/PS1 mice compared to nontransgenic controls. Optogenetic activation of astrocytes at the endogenous frequency of slow waves restored slow-wave power, reduced amyloid deposition, prevented neuronal calcium elevations, and improved memory performance. Our findings revealed malfunction of the astrocytic network driving slow-wave disruptions. Thus, targeting astrocytes to restore circuit activity underlying sleep and memory disruptions in AD could ameliorate disease progression.
Air traffic control forgetting prediction based on eye movement information and hybrid neural network
Authors: Jin Huibin , Gao Weipeng , Li Kun , Chu Mingjian 
Published: August 2023

AbstractControl forgetting accounts for most of the current unsafe incidents. In the research field of radar surveillance control, how to avoid control forgetting to ensure the safety of flights is becoming a hot issue which attracts more and more attention. Meanwhile, aviation safety is substantially influenced by the way of eye movement. The exact relation of control forgetting with eye movement, however, still remains puzzling. Motivated by this, a control forgetting prediction method is proposed based on the combination of Convolutional Neural Networks and Long-Short Term Memory (CNN-LSTM). In this model, the eye movement characteristics are classified in terms of whether they are time-related, and then regulatory forgetting can be predicted by virtue of CNN-LSTM. The effectiveness of the method is verified by carrying out simulation experiments of eye movement during flight control. Results show that the prediction accuracy of this method is up to 79.2%, which is substantially higher than that of Binary Logistic Regression, CNN and LSTM (71.3%, 74.6%, and 75.1% respectively). This work tries to explore an innovative way to associate control forgetting with eye movement, so as to guarantee the safety of civil aviation.
Comparison of genome replication fidelity between SARS-CoV-2 and influenza A virus in cell culture
Authors: Kawasaki Yoshiko , Abe Haruka , Yasuda Jiro 
Published: August 2023

AbstractSince the emergence of COVID-19, several SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) variants have emerged and spread widely. These variants are produced through replication errors of the viral genome by viral RNA-dependent RNA polymerase (RdRp). Seasonal epidemics of influenza are also known to occur because of new variants of influenza A virus (IAV), which are generated by the introduction of mutations by viral RdRp with low fidelity. Variants with different antigenicities appear because of mutations in envelope glycoproteins. In this study, we calculated and compared the mutation rates in genome replication of IAV and SARS-CoV-2. Average mutation rates per passage were 9.01 × 10–5 and 3.76 × 10–6 substitutions/site for IAV and SARS-CoV-2, respectively. The mutation rate of SARS-CoV-2 was 23.9-fold lower than that of IAV because of the proofreading activity of the SARS-CoV-2 RdRp complex. Our data could be useful in establishing effective countermeasures against COVID-19.
Past and future adverse response of terrestrial water storages to increased vegetation growth in drylands
Authors: Liu Kai , Li Xueke , Wang Shudong , Zhou Guangsheng 
Published: August 2023

AbstractThe response of terrestrial water storages to dryland vegetation growth remains poorly understood. Using multiple proxies from satellite observations and model outputs, we show an overall increase (decrease) in vegetation growth (terrestrial water storages) across drylands globally during 1982–2016. Terrestrial water storages in greening drylands correlate negatively with vegetation growth, particularly for cropland-dominated regions, and such response is pronounced when the growth rate of vegetation productivity is high. Reduction in terrestrial water storage is dominated by precipitation and evapotranspiration variability rather by than runoff. We predict reduction in terrestrial water storage of 41–84% by 2100, accompanying expansion of drylands by 4.1–10.6%. Our findings, which indicate sustained adverse response of terrestrial water storage to vegetation growth in drylands, highlight the need for concerted planning for balanced ecological restoration, agricultural management, and water resource utilization that will affect 5.17 billion people, 64% of whom live in developing countries.
Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies
Authors: Shah Ashu , Chaudhary Sanjib , Lakshmanan Imayavaramban , Aithal Abhijit , Kisling Sophia G. , Sorrell Claire , Marimuthu Saravanakumar , Gautam Shailendra K. , Rauth Sanchita , Kshirsagar Prakash , Cox Jesse L. , Natarajan Gopalakrishnan , Bhatia Rakesh , Mallya Kavita , Rachagani Satyanarayana , Nasser Mohd Wasim , Ganti Apar Kishor , Salgia Ravi , Kumar Sushil , Jain Maneesh , Ponnusamy Moorthy P. , Batra Surinder K. 
Published: August 2023

AbstractAberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor prognosis and lethality of pancreatic (PC) and non-small cell lung cancer (NSCLC). To date, most anti-MUC16 antibodies are directed towards the extracellular domain of MUC16 (CA125), which is usually cleaved and shed in the circulation hence obscuring antibody accessibility to the cancer cells. Herein, we establish the utility of targeting a post-cleavage generated, surface-tethered oncogenic MUC16 carboxy-terminal (MUC16-Cter) domain by using a novel chimeric antibody in human IgG1 format, ch5E6, whose epitope expression directly correlates with disease severity in both cancers. ch5E6 binds and interferes with MUC16-associated oncogenesis, suppresses the downstream signaling pFAK(Y397)/p-p70S6K(T389)/N-cadherin axis and exert antiproliferative effects in cancer cells, 3D organoids, and tumor xenografts of both PC and NSCLC. The robust clinical correlations observed between MUC16 and N-cadherin in patient tumors and metastatic samples imply ch5E6 potential in targeting a complex and significantly occurring phenomenon of epithelial to mesenchymal transition (EMT) associated with disease aggressiveness. Our study supports evaluating ch5E6 with standard-of-care drugs, to potentially augment treatment outcomes in malignancies inflicted with MUC16-associated poor prognosis.
Cognitive gripping with flexible graphene printed multi-sensor array
Authors: Mukherjee Tania , Gupta Dipti 
Published: August 2023

AbstractRobotics for task simplification of domestic, household, workplace and other assistive activities require efficient robots with decision-making capabilities. Here we report a fully printed graphene-based capacitive multi-sensor array (CAPSENSAR) employed in a cognitive robotic gripper (COGBOT) for decision-making operations. The CAPSENSAR created a contactless capacitive impression of the gripped object surface to determine the optimum gripping pressure. The controlling unit of the COGBOT was associated with an algorithm to address potential breakage. If slippage was detected via the array, the grip pressure was revised to reduce the possibility for damage. This facilitated slippage-free and damage-resistant gripping of the target objects without user interference. Array fabrication was straightforward using a customizable electrode design with cost-effective and biocompatible materials.
Designing ternary hydrated eutectic electrolyte capable of four-electron conversion for advanced Zn–I2 full batteries
Authors: Li Wenda , Xu Hengyue , Zhang Hongyi , Wei Facai , Zhang Tingting , Wu Yong , Huang Lingyan , Fu Jianwei , Jing Chengbin , Cheng Jiangong , Liu Shaohua 
Published: August 2023

A new class of ternary hydrated eutectic electrolytes is designed that can enable 2I+/I2/2I− redox couple four-electron conversion and oriented dendrite-free Zn plating/stripping for Zn–I2 batteries.
Exploring Alternative Methods to Reduce Milk Flow Rate From Infant Bottle Systems: Bottle Angle, Milk Volume, and Bottle Ventilation
Authors: McGrattan Katlyn Elizabeth , Jansen Gregory Paul , Barrera Jennifer Meraz , Beckstrand Michael 
Published: August 2023

Purpose:
Modifying milk flow rate is a common pediatric dysphagia treatment. Though past investigations have demonstrated how this can be achieved using bottle nipples, little is known about the impact of other bottle modifications. The objective of this investigation is to demonstrate how bottle vent, bottle position, and volume of milk alter bottle pressures and milk flow.

Method:
A Dr. Brown's bottle filled with formula was secured to a retort stand and inverted to allow milk to free flow from a Level 1 nipple. Milk flow rate and bottle pressures were calculated under three conditions: (a) with and without a vent in place; (b) with varying volumes of milk (1–4 oz); and (c) in horizontal, semi-inverted, and completely inverted positions. Differences between flow rates under the conditions were tested using repeated-measures analysis of variance.

Results:

Upon inversion, milk dripped from both vented and unvented bottles. Dripping continued throughout the 20-min testing period in the vented bottle; however, as air pressure and hydrostatic pressure declined (
p
< .01) in the unvented bottle, milk flow slowed and eventually ceased (
p
< .001). As angle of bottle inversion increased, hydrostatic pressure and milk flow rate had corresponding increases as well (
p
< .001). Hydrostatic pressure increased an average of 1.4 ± 0.12 mm Hg per additional ounce of formula that was added to the bottle, with corresponding increases in milk flow rate observed (
p
< .001).

Conclusions:
Milk flow rate can be altered by feeding conditions outside of bottle nipples alone. Future work examining the clinical significance of these modifications is warranted to determine optimal interventions.
SDAUNet: A simple dual attention mechanism UNet for mixed noise removal
Authors: Jiang Jielin , Hong Xiangming , Zhao Yingnan , Xu Xiaonglong , Cui Yan 
Published: August 2023

AbstractConvolutional neural networks (CNNs) have demonstrated impressive results in additive white Gaussian noise removal due to their strong fitting ability. However, their performance in mixed noise removal remains unsatisfactory, primarily due to their limited receptive field that focuses only on the local features of images and disregards global information. To ameliorate this issue, recent state‐of‐the‐art approaches employ attention mechanism (AM) to capture the global information. However, most AM based methods still suffer from low computational efficiency. In this paper, a novel model named simple dual attention mechanism UNet (SDAUNet) for mixed noise removal is proposed. In SDAUNet, the UNet architecture is used to gradually acquire multi‐scale image features and provide a more comprehensive and accurate representation of the image features than other CNNs. A simple dual attention convolutional block is presented to acquire the global image features that can successfully capture image details with a low burden. The experimental results demonstrate that the SDAUNet model can achieve better measurement metrics and visual performance than other state‐of‐the‐art methods.
Developing an integrated medication adherence system: Exploring the potential of i‐Ware's augmented reality goggles and mobile application
Authors: Taghian Aya , Abd El‐Malek Ahmed H. , Sayed Mohammed S. , Abo‐Zahhad Mohammed 
Published: August 2023

AbstractMedical therapists often manage medications to improve therapeutic outcomes for their patients. For senior patients who take multiple drugs to manage various conditions, medication adherence is critical. To provide an immersive and engaging medication reminder experience, the authors propose i‐Ware, a smart wearable m‐Health (mobile health) device. The system's hardware and software were co‐designed to meet non‐functional requirements. The model reminds patients to take their medication, and the augmented reality goggles aid those who struggle to manage their medicine. The navigation features help users find their way home, and the audio feature reads out the date and time, useful for patients with low vision. The i‐Ware system has the potential for real‐world application and can significantly improve medication adherence. As an AR‐enabled medicine reminder, i‐Ware is an innovative solution for medication management in senior patients.
Revival and development of classical photography in contemporary perspective
Authors: Ma Yanhong 
Published: August 2023

Photography technology after 180 years of baptism, today’s photography technology has been monopolized by digital images, this monopoly can be described as a subversion of the traditional silver salt image, just like the painting art a hundred years ago and nowadays the photography art is in the process of change. In this ever-changing era, people are increasingly pursuing personalization and art, and photography is no exception. However, the detail of the most representative contemporary works of photographic art will unexpectedly promote the development of the classical craft of photography and be presented in a quiet way in today’s art market, which has aroused a warm response. The modern application of classical photography techniques not only opens us up to a new field, but also shows us the great potential of photography technology in the new era.
Fünf nach zwölf – zur Resistenzlage
gastrointestinaler Nematoden bei kleinen Wiederkäuern in
Deutschland
Authors: Voigt Katja , Geiger Maximilian , Jäger Miriam 
Published: August 2023

ZusammenfassungAnthelminthikaresistenzen haben weltweit ein besorgniserregendes Ausmaß
erreicht, das die Weidehaltung kleiner Wiederkäuer in einigen Regionen
der Welt bereits ernsthaft gefährdet. Auch in Europa hat sich die
Resistenzlage im letzten Jahrzehnt dramatisch verschlechtert. Der Artikel fasst
den Stand der Wissenschaft zum Vorkommen von Anthelminthikaresistenzen bei
kleinen Wiederkäuern mit Schwerpunkt auf Deutschland und seinen
Nachbarländern zusammen, erläutert Mechanismen der
Resistenzentstehung und -verbreitung und gibt Hinweise für einen
verantwortungsvollen Umgang mit Anthelminthika in der tierärztlichen
Praxis.
Pattern of Care and Outcomes of Gallbladder Cancer Patients: Retrospective Study from a High Incidence Region in India
Authors: Kashyap Lakhan , Singh Arpita , Tomar Subham , Gupta Anuj , Sansar Bipinesh , Chaudhary Amit Kumar , Mishra Bal Krishna , Sambasivaiah Kuraparthy , Kapoor Akhil 
Published: August 2023

Introduction Gallbladder cancer (GBC) is the 20th most common cancer in India with a crude incidence rate of 2.3 per 100,000 persons. Of note, it is relatively common in states which fall in the Gangetic plains. Patients often present in the advanced stage and have an unfavorable prognosis.
Materials and Methods From January to June 2021, 170 treatment-naive GBC (adenocarcinoma) patients who were registered at a tertiary care cancer center in North India, were included. Data were extracted from electronic medical records and was analyzed with SPSS.
Results Median age was 56 years (range 32–77 years) and 65.5% (n = 112) were female. Incidental GBC was found in 20% patient (n = 34). Majority of patients (79.4%, n = 135) had preserved performance status. Advanced GBC was present in 85.8% (n = 146) patients (locally advanced = 37.0% and metastatic = 48.8%). Biliary drainage procedure was performed in 24% of patients (68% of patients with obstructive jaundice). More than half of patients (53.5%) were lost to follow-up without any treatment. There were 33 patients (19.4%) who underwent surgery and 20 of them received neoadjuvant chemotherapy. Adjuvant chemotherapy and adjuvant radiotherapy were received by 13 and 2 patients, respectively. Palliative chemotherapy was administered to 46 patients. The most common chemotherapy regimen was gemcitabine-cisplatin. At a median follow-up of 1.7 months (95% confidence interval, 1–2.4 months), 42 patients (24%) progressed and 24 patients (14%) died, with 6 months estimated progression-free survival and overall survival being 60.2 and 79%, respectively.
Conclusion GBC is an aggressive and lethal malignancy predominantly affecting females in the fifth decade with dismal outcomes. Improved access to health care, an aggressive approach in operable cases, and optimization of systemic and adjuvant therapy are the need of the hour.
Chemoradiation, Consolidation Chemotherapy, and Watch and Wait for Early Rectal Cancer
Authors: Cerdan-Santacruz Carlos , São Julião Guilherme Pagin , Vailati Bruna Borba , Perez Rodrigo Oliva 
Published: August 2023

AbstractAs watch and wait has become an attractive management alternative among patients with rectal cancer who achieve a clinical complete response to neoadjuvant chemoradiation, the focus of organ preservation has now shifted toward the use of this approach in patients with early rectal cancer. These patients would otherwise be treated without the use of neoadjuvant therapy for oncological reasons. The sole purpose of any neoadjuvant treatment here would be the achievement of a complete clinical response in an attempt to avoid total mesorectal excision. This has become particularly interesting after the incorporation of total neoadjuvant therapy regimens. These regimens have resulted in significantly higher rates of complete tumor regression and therefore become an interesting alternative among early rectal cancer patients where organ preservation is desired. The present review provides an overview of the currently available evidence and the preliminary experience with this rather controversial approach.
Treatment of Microsatellite-Unstable Rectal Cancer in Sporadic and Hereditary Settings
Authors: Anderson Cristan E. , Liska David 
Published: August 2023

AbstractMicrosatellite instability is rare in rectal cancer and associated with younger age of onset and Lynch syndrome. All rectal cancers should be tested for microsatellite instability prior to treatment decisions. Patients with microsatellite instability are relatively resistant to chemotherapy. However, recent small studies have shown dramatic response with neoadjuvant immunotherapy. Patients with Lynch syndrome have a hereditary predisposition to cancer and thus an elevated risk of metachronous cancer. Therefore, while “watch and wait” is a well-established practice for sporadic rectal cancers that obtain a complete clinical response after chemoradiation, its safety in patients with Lynch syndrome has not yet been defined. The extent of surgery for patients with Lynch syndrome and rectal cancer is controversial and there is significant debate as to the relative advantages of a segmental proctectomy with postoperative endoscopic surveillance versus a therapeutic and prophylactic total proctocolectomy. Surgical decision making for the patient with Lynch syndrome and rectal cancer is complex and demands a multidisciplinary approach, taking into account both patient- and tumor-specific factors. Neoadjuvant immunotherapy show great promise in the treatment of these patients, and further maturation of data from prospective trials will likely change the current treatment paradigm. Patients with Lynch syndrome and rectal cancer who do not undergo total proctocolectomy require yearly surveillance colonoscopies and should consider chemoprophylaxis with aspirin.