bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of supraclavicular lymph node clinical target volume delineation in breast cancer: a single center experience and recommendation
Authors: Li Li , Zhang Hongyan , Wang Linwei , Xie Conghua , Yu Haijun , Zhong Yahua 
Published: April 2023

Abstract
Background: Prophylactic irradiation of supraclavicular lymph node drainage areas can improve the regional control rate of lymph node-positive breast cancer and reduce breast cancer-related mortality. However, many inconsistencies exist in the clinical target volume delineation of supraclavicular lymph node drainage in patients with breast cancer.
Methods: We retrospectively analyzed 42 breast cancer patients with supraclavicular lymph node metastasis at our hospital between January 2017 and December 2021. Among these cases, 32 were locally advanced and 10 were stage IV at initial treatment. A patient with breast cancer who did not undergo dissection of the upper and lower clavicle lymph nodes at our hospital was selected as a standard patient. A contrast-enhanced computed tomography (CT) scan for positioning was used as a template image, and blood vessels, muscles, and bony landmarks were used as references for positioning. The metastatic supraclavicular lymph nodes were identified in all enrolled patients and projected into the template CT images.
Results: The metastatic pattern of supraclavicular lymph node in breast cancer was proposed: distribution along the posterolateral border of the internal jugular vein (medial supraclavicular group) and the transverse jugular vein (lateral supraclavicular group). We theorized that the lateral and posterior borders of the clinical target volume in the supraclavicular region should include the lymph nodes in the posterior triangle of the neck (level V). If the metastasis axillary lymph node is extensive, then the superior border of the supraclavicular region should be moved upward appropriately.
Conclusions: This study analyzed patients with breast cancer and supraclavicular lymph node metastasis at initial treatment, explored the metastatic pattern of supraclavicular lymph node, and applied anatomical knowledge to further optimize the target volume delineation of supraclavicular lymph node drainage area in breast cancer.
A conservative system based on a triangular wave memristor and its application in image encryption
Authors: Du Chuanhong , Liu Licai , Zhang Zhengping , Yu Shixing 
Published: April 2023

Abstract
Reconstruction techniques can capture the attractor data of dissipative chaotic systems, which will lead to a threat to the security of the cryptosystem. Since conservative chaotic systems do not form chaotic attractors, they can avoid the defects of the dissipative system and resist attacks. This paper aims to construct a new type of active charge-controlled memristor based on a triangular wave and apply it to build a non-Hamiltonian globally conservative circuit, the characteristic roots of which are all on the imaginary axis. The system is critically stable and presents extremely high sensitivity to the initial values, exhibiting heterogeneous multistability and homogeneous multistability with local amplitude modulation. This special multistability is of great significance to engineering applications. In addition, as the hardware accuracy is limited and only a few conservative systems have been implemented digitally, the DSP platform is employed herein for the physical implementation of the proposed system. In the end, we applied the novel system to a plaintext-related image encryption algorithm. The results show that the system not merely can resist the risk of data reconstruction, but also has excellent random characteristics, and is suitable for encryption.
Combined percutaneous retrograde intramedullary pinning and open reduction and screw fixation in the treatment of displaced Neer three-part fractures of the humerus.
Authors: Bouaicha Walid , Jlidi Mohamed , Kharrat Melek , Lammouchi Mouldi , Daas Selim 
Published: April 2023

Abstract
Objective:
Fractures of the proximal humerus are common injuries. Treatment options vary according to fracture patterns, surgeon preferences and implant availability. Increasing interest is being given to minimally invasive surgical procedures. In this article an original surgical procedure is described combining percutaneous retrograde intramedullary pinning (PRIP) and open reduction with lag screw fixation in the treatment of displaced Neer three-part fractures of the proximal humerus.
Methods:
We report on the preliminary results of a retrospective series of six patients treated with PRIP and open lag screw fixation reviewed with a mean follow-up of 25 months.
Radiologic assessment was made on plain x-rays. Functional results were assessed according to the Constant and Murely score, the disabilities of the arm, shoulder and hand (DASH) score, and the analogue visual score (AVS).
Results:
Radiologic reduction was “anatomical” in all the patients. The average Absolute Constant Score (ACS) was 55.16 (range from 30 to 80). The average DASH score was 27.3 (range from 19 to 36). Only one case of proximal pin migration was reported.
Conclusion:
The association of PRIP with open reduction and lag screw fixation can be an interesting alternative yielding good results in our developing countries where more advanced fixation devices are not readily available.
Thermoelectric optimization using first principles calculation and single parabolic band model: a case of the heavily doped oxide semiconductor
Authors: Raharjo Bambang Mulyo , Kurniawan Budhy , Soegijono Bambang , Munazat Dicky Rezky , Razaq Dhawud Sabilur , Suprayoga Edi 
Published: April 2023

Abstract
Conducting optimization calculations for thermoelectric performance can be beneficial in guiding the direction of further experimental work. In our study, we utilize a combination of the first principle and restructured single parabolic band model to investigate heavily doped semiconductors based on manganite. Ca0.5L0.5MnO3 (CLMO) and Ca0.5L0.25Bi0.25MnO3 (CLBMO) as samples shows optimization of 30% and 69% respectively at a temperature of 800 K from their respective optimal values. In addition, both samples show two to three orders of magnitude smaller lattice thermal conductivity than their electronic thermal conductivity. This excludes complex phononic transport mechanisms from the calculation of the figure of merit (ZT). The ZT calculations of CLMO and CLBMO are corrected by the ratio of the transport relaxation time of electrical conductivity to the transport relaxation time of electronic thermal conductivity, resulting in ZT values of 0.063 and 0.327 at a temperature of 800 K, respectively.
Morphological Characterisation of Printed Nanostructured Networks using High-resolution 3D FIB-SEM Nanotomography
Authors: Gabbett Cian , Doolan Luke , Synnatschke Kevin , Gambini Laura , Coleman Emmett , Kelly Adam , Liu Shixin , Caffrey Eoin , Munuera Jose , Murphy Catriona , Sanvito Stefano , Jones Lewys , Coleman Jonathan 
Published: April 2023

Abstract
Networks of solution-processed nanomaterials are becoming increasingly important across applications in electronics, sensing and energy storage/generation. Although the physical properties of these devices are often completely dominated by network morphology, the network structure itself remains difficult to interrogate. Here, we utilise FIB-SEM nanotomography to quantitatively characterise the morphology of nanostructured networks and their devices using nanometre-resolution 3D images. The influence of nanosheet/nanowire size on network structure in printed films of graphene, WS2 and silver nanosheets, as well as networks of silver nanowires, is investigated. We present a comprehensive toolkit to extract morphological characteristics including network porosity, tortuosity, specific surface area, pore dimensions and nanosheet orientation, which we link to network resistivity. By extending this technique to interrogate the structure and interfaces within vertical printed heterostacks, we demonstrate the potential of this technique for device characterisation and optimisation.
Six-month follow-up of periodontal condition and oral mucosa lesions in arthritis patients undergoing anti-tumour necrosis factor-α therapy
Authors: Tar Ildikó , Végh Edit , Martos Renáta , Soós Boglárka , Kacsándi Dorottya , Márton Ildikó , Szekanecz Zoltán 
Published: April 2023

Abstract
Introduction: Peridontitis has been associated with inflammatory rheumatic diseases.
Objectives: We evaluated oral mucosal, periodontal, and periapical dental condition of 24 arthritis patients at baseline and after six months of biological therapy and we also determined if their baseline dental condition would affect the outcome of biological therapy.
Methods: The mean age of these patients was 48.8±13.8 years and their mean disease duration was 7.81±7.29 years. Clinical responder (R) and non-responder (NR) status was determined after 6 months of anti-TNF treatment. Altogether 20 patients (9 RA and 11 AS) started on 50 mg etanercept (ETN) SC weekly, while 4 patients (all RA) received certolizumab pegol (CZP; 400 mg at 0, 2 and 4 weeks and thereafter 200 mg every two weeks SC).
Results: During the six months of treatment period, 6 patients (3 female RA and 3 male AS) terminated the study prematurely as they did not respond to treatment (NR). By the end of study period, oral lichen planus (OLP) lesions developed on the oral mucosa of two patients (1 male and 1 female). When comparing periodontal indices at baseline and after 6 months of anti-TNF treatment in R group, GI increased (0.65±0.34 vs 0.88±0.30; p<0.05), while CPDmax (4±1.94 vs 2.72±1.36; p<0.05) and CALmax decreased (5.22±2.56 vs 2.72±1.36; p<0.05) over time. Therapeutic success was associated with older age (R: 52.7±11.8 years; NR: 37.2±13.4 years; p<0.05). In addition, there was a significant difference in mean baseline GI in R (0.65±0.39) and NR patients (0.52±0.07; p<0.05).
Conclusions: We postulate that younger age and mild gingival inflammation in such patients may result in anti-TNF therapy failure. Certainly, further studies are needed to elucidate this issue.
Distance to Frontier, Manager Turnover, and Economic Growth
Authors: Muranaka Alex , Correia Eduardo , Ribeiro Priscila 
Published: April 2023

Abstract

We apply a dictionary method to Standard & Poor’s Capital IQ microdata on CEO changes, in order to construct a country-level manager turnover index. Next, we study the relation between manager turnover, distance to the technology frontier and economic growth in a panel of countries. Our findings give empirical support to Acemoglu, Aghion and Zilibotti’s (2006) theoretical model: low manager turnover rates become negatively correlated with growth as countries get closer to the technology frontier. Our results are robust to different (mild or strict) definitions of manager change motive, as well as to a weighted (by firm size) version of the turnover index. We also address endogeneity issues by instrumenting our manager turnover index with the Doing Business “number of procedures to open a new business” variable.
JEL codes: O4 , O43 , O47 , O33 , G32, G34
Papillomacular Bundle Defect (PMBD) in Glaucoma Patients with High Myopia: Frequency and Risk Factors
Authors: Huh Min Gu , Shin Young In , Jeong Yoon , Kim Young Kook , Jeoung Jin Wook , Park Ki Ho 
Published: April 2023

Abstract
Little is known about the papillomacular bundle defect (PMBD) in glaucoma. As such, we investigated the frequency of PMBD in glaucoma patients with high myopia, and its risk factors. In this retrospective, cross-sectional study, Retinal nerve fiber layer (RNFL) defect was analyzed in 92 glaucomatous eyes with high myopia (axial length of 26.0 mm or more or an average spherical value of –6.0 diopters or less). After dividing them into two groups with and without PMBD, respectively, the clinical characteristics of the groups were compared and analyzed. The mean age of the patients was 52.1 ± 10.5 years, and there were 53 males and 39 females. PMBD were observed in 55 eyes (59.8%). There was no significant intergroup difference in baseline or follow-up intraocular pressure (IOP). Parapapillary atrophy (PPA)-to-Disc-area ratio (OR 3.83, CI:1.58 – 10.27), lamina cribrosa defect (LCD; OR 2.92, CI :1.14 – 8.13, p = 0.031) and central visual field defect (CVFD; OR 3.56, CI : 1.38 – 9.58, p = 0.010) were significantly associated with the PMBD group.
Safety and effectiveness of opioid-free anesthesia in thoracoscopic surgery: a propensity-score matching analysis
Authors: Zhang Shanshan , Zhang Jianmin , Zhang Ran 
Published: April 2023

Abstract
Background: The aim of this study was to observe the effect of opioid-free anesthesia (OFA) on intraoperative hemodynamics and postoperative analgesia in thoracoscopic surgery.
Methods: A total of 101 thoracoscopic surgery patients who received the OFA technique were compared with 101 thoracoscopic surgery patients who received standard opioid-containing anesthesia(SOA),. Heart rate (HR) and mean arterial blood pressure (MAP) were measured before anesthesia induction, immediately after endotracheal intubation, at the beginning of surgery, and 10, 20, and 30 min after the beginning of surgery. Total amount of intraoperative infusion, frequency of vasoactive drug use, morphine ingested via the patient-controlled intravenous analgesia(PCIA) 24 h post-surgery, and visual analogue scale (VAS) scores at rest and activity on the first day after surgery were analyzed.
Results: There was no significant difference in intraoperative HR between the two groups (F=0.889, P=0.347); however, there was significant difference in intraoperative MAP (F=16.709, P<0.001), which was lower in SOA patients than in OFA patients. The frequency of vasoactive drug use and the amount of infusion was less in OFA patients (P=0.001). The amount of morphine used by the PCIA 24 h after surgery was significantly lower in OFA patients (OFA, 1.8 [0, 4.8] mg vs. STD, 3.6 [0.6, 23] mg, P<0.001). There was no significant difference in VAS scores at rest (P=0.745) or during activity (P=0.792) on the first day after surgery.
Conclusions: Compared with SOA, OFA can effectively maintain the stability of intraoperative MAP, reduce the incidence of hypotension, and effectively reduce the consumption of opioids after surgery.
A novel defect detection system for complex freeform surface structures
Authors: Xie Fengfan , Lu Xinyu , Xu Xincai , Gao Shaohua , Chen Jiaan , Wang Kaiwei , Bai Jian 
Published: April 2023

Abstract

In recent years, freeform surfaces have been widely used in various industries with the rapid development of manufacturing technology. However, the complex 3D structures and other surface properties of the freeform surface products challenge current visual inspection systems. To deal with the problem and meet the demand, we propose a novel, deep learning-based defect detection method for complex freeform surface structures in the injection industry. We first design a system of Multi-Lights Multi-Cameras with Polarizer, in which polarization is used to eliminate glare caused by freefrom surfaces and multi-illumination is used to enhance the visibility of certain defects. Then a convolutional neural network model based on YOLOv5 is utilized to detect small defects in images. Particularly, we raise several effective and easily-implemented strategies and improve the performance of the model significantly. Experimental results on our self-made dataset show that the improved model achieves a mean average precision (mAP) of 86.2% with 5.1% higher than the Baseline. Moreover, testing on the production line shows our detection system can benefit the related factory. Our work provides a promising approach to facilitate the development of visual inspection for products with complex freeform surfaces.
Impaired biosynthesis of ergosterol confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in a PDR16-dependent manner
Authors: Fukuda Shizuka , Kono Yushi , Ishibashi Yohei , Tabuchi Mitsuaki , Tani Motohiro 
Published: April 2023

Abstract
Complex sphingolipids and sterols are coordinately involved in various cellular functions, e.g. the formation of lipid microdomains. Here we found that budding yeast exhibits resistance to an antifungal drug, aureobasidin A (AbA), an inhibitor of Aur1 catalyzing the synthesis of inositolphosphorylceramide, under impaired biosynthesis of ergosterol, which includes deletion of ERG6, ERG2, or ERG5 involved in the final stages of the ergosterol biosynthesis pathway or miconazole; however, these defects of ergosterol biosynthesis did not confer resistance against repression of expression of AUR1 by a tetracycline-regulatable promoter. The deletion of ERG6, which confers strong resistance to AbA, results in suppression of a reduction in complex sphingolipids and accumulation of ceramides on AbA treatment, indicating that the deletion reduces the effectiveness of AbA against intracellular AbA activity. Previously, we reported that a similar effect to AbA sensitivity was observed when PDR16 or PDR17 was overexpressed. It was found that the effect of the impaired biosynthesis of ergosterol on the AbA sensitivity is completely abolished on deletion of PDR16. In addition, an increase in the expression level of Pdr16 was observed on the deletion of ERG6. These results suggested that abnormal ergosterol biosynthesis confers resistance to AbA in a PDR16-dependent manner, implying a novel functional relationship between complex sphingolipids and ergosterol.
The Mediating Role of Systemic Inflammation and Moderating Role of Race/Ethnicity in Racialized Disparities in Incident Dementia: A Decomposition Analysis
Authors: Tejera César Higgins , Ware Erin , Hicken Margaret , Kobayashi Lindsay , Wang Herong , Adkins-Jackson Paris , Blostein Freida , Zawistowski Matthew , Mukherjee Bhramar , Bakulski Kelly 
Published: April 2023

Abstract

Background: Exposure to systemic racism is linked to increased dementia burden. To assess systemic inflammation as a potential pathway linking exposure to racism and dementia disparities, we investigated the mediating role of C-reactive protein (CRP), a systemic inflammation marker, and the moderating role of race/ethnicity on racialized disparities in incident dementia.

Methods: In the US Health and Retirement Study (n=5,143), serum CRP was measured at baseline (2006, 2008 waves). Incident dementia was classified by cognitive tests over a six-year follow-up. Self-reported racialized categories were a proxy for exposure to the racialization process. We decomposed racialized disparities in dementia incidence (non-Hispanic Black and/or Hispanic vs. non-Hispanic White) into 1) the mediated effect of CRP, 2) the moderated portion attributable to the interaction between racialized group membership and CRP, and 3) the controlled direct effect (other pathways through which racism operates).

Results: The 6-year cumulative incidence of dementia was 15.5%. Among minoritized participants (i.e., non-Hispanic Black and/or Hispanic), high CRP levels (> 75th percentile or 4.57mcg/mL) was associated with 1.27 (95%CI: 1.01,1.59) times greater risk of incident dementia than low CRP (<4.57mcg/mL). Decomposition analysis comparing minoritized versus non-Hispanic White participants showed that the mediating effect of CRP accounted for 2% (95% CI: 0%, 6%) of the racial disparity, while the interaction effect between minoritized group status and high CRP accounted for 12% (95% CI: 2%, 22%) of the disparity. Findings were robust to potential violations of causal mediation assumptions.

Conclusions: Systemic inflammation mediates racialized disparities in incident dementia.
Damage identification of wire rope under noise background via Light- EfficientNetV2 and Magnetic flux leakage image
Authors: Huang Shengping , Wang Zhongqiu , Yang Jianhua , Zhao Anji , Wang Liang , Qu Haoyang 
Published: April 2023

Abstract
Magnetic flux leakage (MFL) testing, non-destructive testing, can prevent some major accidents of hoist equipment by identifying the damage of wire ropes. However, in harsh working conditions such as mines and oil wells, the inevitable vibration and swing of wire rope will generate noise and interfere with the MFL signal, which makes us difficult to identify the damage. As a classification network, Convolutional neural network (CNN) is positive in recognition accuracy and noise resistance, but it hardly uses in wire rope damage classification. To improve the accuracy of wire rope damage identification under noise background, we propose a method of wire rope damage identification via Light-EfficientNetV2 and MFL image. First, the MFL signal is segmented and rearranged to form the MFL image, and then the image is classified by Light-EfficientNetV2. To improve the classification efficiency, we reduce the layers of EfficientNetV2 to make it lighter. Finally, the availability of this method is proved by the validation set. Compared with four neural networks, the accuracy is the highest. Moreover, as the noise increased, the accuracy of Light-EfficientNetV2 is higher than EfficientNetV2, which has application value in the wire rope damage identification under noise background.
Reassortment and Genomic Analysis of a G9P[8]-E2 Rotavirus Isolated in China
Authors: PENG RUI , Li Dandi , Wang Jindong , Xiong Guangping , Wang Mengxuan , Liu Dan , Wei Yuhang , Pang Lili , Sun Xiaoman , Li Huiying , Kong Xiangyu , Shahar Saleha , Duan Zhaojun 
Published: April 2023

Abstract

Objective
To isolate a prevalent G9P[8] group A rotavirus (RVA) (N4006) in China and investigate its genomic and evolutionary characteristics, with the goal of facilitating the development of a new rotavirus vaccine.
Methods
The RVA G9P[8] genotype from a diarrhea sample was passaged in MA104 cells. The virus was evaluated by TEM, polyacrylamide gel electrophoresis, and indirect immunofluorescence assay. The complete genome of virus was obtained by RT-PCR and sequencing. The genomic and evolutionary characteristics of the virus were evaluated by nucleic acid sequence analysis with MEGA ver. 5.0.5 and DNASTAR software. The neutralizing epitopes of VP7 and VP4 (VP5* and VP8*) were analyzed using BioEdit ver. 7.0.9.0 and PyMOL ver. 2.5.2.
Results
The RVA N4006 (G9P[8] genotype) was adapted in MA104 cells with a high titer (105.5 PFU/mL). Whole-genome sequence analysis showed N4006 to be a reassortant rotavirus of Wa-like G9P[8] RVA and the NSP4 gene of DS-1-like G2P[4] RVA, with the genotype constellation G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1 (G9P[8]-E2). Phylogenetic analysis indicated that N4006 had a common ancestor with Japanese G9P[8]-E2 rotavirus. Neutralizing epitope analysis showed that VP7, VP5*, and VP8* of N4006 had low homology with vaccine viruses of the same genotype and marked differences with vaccine viruses of other genotypes.
Conclusion
The RVA G9P[8] genotype with the G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1 (G9P[8]-E2) constellation predominates in China and may originate from reassortment between Japanese G9P[8] with Japanese DS-1-like G2P[4] rotaviruses. The antigenic variation of N4006 with the vaccine virus necessitates an evaluation of the effect of the rotavirus vaccine on G9P[8]-E2 genotype rotavirus.