bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of combined high-frequency repetitive transcranial magnetic stimulation and cervical nerve root magnetic stimulation on upper extremity motor recovery following stroke
Authors: Wu Xiaofang , Wang Rui , Wu Qunqiang , Liao Chunhua , Zhang Jianshe , Jiao Huiduo , Chen Baolin , Wang Shuyan , Liu Rui 
Published: February 2023

IntroductionUpper limb motor impairments after stroke cause patients partial or total loss of the capability of performing daily living, working, and social activities, which significantly affects the quality of life (QoL) of patients and brings a heavy burden to their families and society. As a non-invasive neuromodulation technique, transcranial magnetic stimulation (TMS) can act not only on the cerebral cortex, but also on peripheral nerves, nerve roots, and muscle tissues. Previous studies have shown that magnetic stimulation on the cerebral cortex and peripheral tissues has a positive effect on the recovery of upper limb motor function after stroke, however, few studies have reported the combination of the two.ObjectiveThis study was to investigate whether high frequency repetitive transcranial magnetic stimulation (HF-rTMS) combined with cervical nerve root magnetic stimulation more effectively ameliorates upper limb motor function in stroke patients. We hypothesized that the combination of the two can achieve a synergistic effect and further promotes functional recovery.MethodsSixty patients with stroke were randomly divided into four groups and received real or sham rTMS stimulation and cervical nerve root magnetic stimulation consecutively before other therapies, once daily over five fractions per week for a total of 15 times. We evaluated the upper limb motor function and activities of daily living of the patients at the time of pre-treatment, post-treatment, and 3-month follow up.ResultsAll patients completed study procedures without any adverse effects. The upper limb motor function and activities of daily living improved in patients of each group were improved after treatment (post 1) and 3 months after treatment (post 2). Combination treatment was significantly better than single treatments alone or sham.ConclusionBoth rTMS and cervical nerve root magnetic stimulation effectively promoted upper limb motor recovery in patients with stroke. The protocol combining the two is more beneficial for motor improvement and patients can easily tolerate it.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR2100048558.
Modeling lacto-vegetarian, pescatarian, and “pescavegan” USDA food patterns and assessing nutrient adequacy for healthy non-pregnant, non-lactating adults
Authors: Hess Julie M. , Comeau Madeline E. 
Published: February 2023

IntroductionThe 2020–2025 Dietary Guidelines for Americans (DGA) includes a Healthy Vegetarian Dietary Pattern (HVDP) with dairy foods and eggs as one of its three recommended dietary patterns for non-pregnant, non-lactating healthy adults. This study evaluates whether pescatarian, lacto-vegetarian, and “pescavegan” adaptations of the HVDP can be nutritionally adequate if modeled with foods recommended by the DGA.MethodsThe nutrient composition of these three alternative models of the HVDP were assessed at 1, 800-, 2, 000-, 2, 200-, and 2,400- kcal/day using similar food pattern modeling procedures as the 2020 DGA. For the pescatarian and pescavegan models, 0.5 ounce-equivalent of refined grains per day was replaced with seafood. For the lacto-vegetarian and pescavegan models, eggs were replaced with equal proportions of the other vegetarian protein foods. In the pescavegan model, dairy foods were replaced by a dairy alternative group comprised of fortified soy milk and soy yogurt.ResultsAll models at all energy levels were within Acceptable Macronutrient Distribution Ranges (AMDRs) for all macronutrients, contained ≤5% of total kcal from saturated fat, and met recommendations for most micronutrients. Nutrients provided below the Dietary Reference Intakes (DRIs) in these models included iron, sodium, vitamin D, vitamin E, and choline. Micronutrients provided at less than 50% of their respective DRIs included vitamin D and choline.DiscussionAdapting the HVDP for lactovegetarian, pescatarian, and pescavegan dietary patterns provided adequate amounts of macronutrients and most micronutrients.
Earlier anti-TNF therapy reduces the risk of malnutrition associated with alterations in body composition in patients with Crohn’s disease
Authors: Wang Yuexin , Yao Danhua , He Yining , He Qi , Li Yousheng 
Published: February 2023

BackgroundAnti-TNF therapy has been found to exert an influence on long-term nutritional status and even reverse malnutrition in patients with Crohn’s disease.Aimsto observe the effect of anti-TNF therapy on nutritional status in patients with Crohn’s disease, investigate the correlation between the timing of anti-TNF therapy and the human body composition and examine independent body composition factors for predicting malnutrition in these patients.MethodsThis was a retrospective study of 115 patients with Crohn’s disease. Body composition parameters were assessed by bioelectrical impedance analysis. The nutritional status of the patients was determined by NRS2002 and MNA.ResultsThe BMI, BFMI, FFMI, BCMI, SMI, BMC, intracellular water, protein and BMR were significantly lower in patients without any biologic agents (p &lt; 0.05). Negative correlations were found between BMC, intracellular water, extracellular water, protein and BMR and the interval between the first symptom and first dose by Spearman’s correlation analysis (r &lt; 0, p &lt; 0.05). Low BMI (OR 0.602, 95% CI 0.434–0.836, p = 0.002), low FFMI (OR 0.678, 95% CI 0.507–0.906, p = 0.009), and low BCMI (OR 0.564, 95% CI 0.367–0.868, p = 0.009) were independent risk factors for malnutrition in Crohn’s disease patients. Anti-TNF therapy tended to reduce the malnutrition probability as assessed by Cox regression analysis (OR: 0.217, 95% CI 0.057–0.821, p = 0.024).ConclusionBody composition analysis is predictive of malnutrition in patients with Crohn’s disease. Early application of anti-TNF therapy significantly affected skeletal muscle mass, fat mass and bone mineral content, supporting their long-term nutritional status and reducing their probability of malnutrition.
Comparison of diagnostic and treatment processes among pediatric and adolescents and young adults’ populations suffering from acute lymphoblastic leukemia and lymphomas
Authors: Abdulaziz-Opiela Gazala , Sobieraj Anna , Płotka Anna , Więckowska Barbara , Gil Lidia , Derwich Katarzyna 
Published: February 2023

IntroductionAcute lymphoblastic leukemia (ALL) and lymphomas affect both pediatric and adult populations, therefore, they might be treated by pediatric or adult centers.It has been proven that the prognosis among adolescents and young adults (AYA) is poorer than among children, which remains a subject of research. Many factors are suspected to affect the diagnostic and treatment processes in adolescents and young adults, one of them being the organization of the healthcare system.The aimof the studywas to compare the time intervals between different events on disease trajectory in pediatric and AYA groups suffering from ALL and lymphomas.MethodsWe collected data on 81 patients diagnosed with ALL (50 children and 31 AYAs) and 100 patients diagnosed with lymphomas (50 children and 50 AYAs). Statistical analysis was performed in order to compare the groups.ResultsThe results confirmed the hypothesis that the duration of the diagnostic process differs significantly between groups. For patients with ALL, the analyzed time intervals were significantly shorter in the pediatric group than in the AYA group: first contact with a GP - admission to Hematology Department (2 vs. 5 days; pvalue= 0.004), first contact with a GP - treatment (6 vs. 12 days, p-value=0.001), diagnosis - treatment (1 vs. 3 days, p-value=0.003). In the case of patients suffering from lymphomas, the results were similar. The analyzed time intervals were significantly shorter in the pediatric group than in the AYA group: first contact with a GP- diagnosis (21 vs. 40.5 days, p-value&lt;0.0001), first contact with a GP - treatment (27 vs. 65 days, p-value&lt;0.0001). Trend analysis showed that the longer patients had presented symptoms before contacting the primary care physician, the longer they waited for the beginning of treatment both in ALL and lymphomas groups (p-values=0.0129 and 0.0038 respectively).DiscussionAs the diagnostic and treatment processes are longer for AYA patients, actions must be undertaken in order to ensure equality and improve the healthcare system in Poland and possibly other countries.
The price of neonatal intensive care outcomes – in-hospital costs of morbidities related to preterm birth
Authors: Rolnitsky Asaph , Unger Sharon , Urbach David , Bell Chaim M. 
Published: February 2023

BackgroundNeonatal care for preterm babies is prolonged and expensive. Our aim was to analyze and report costs associated with common preterm diagnoses during NICU stay.MethodsWe analyzed data from the Ontario healthcare data service. Diagnoses were collated by discharge ICD codes, and categorized by gestational age. We calculated typical non parametric statistics, and for each diagnosis we calculated median shifts and generalized linear mode.ResultsWe included data on 12,660 infants between 23 and 30 weeks gestation in 2005-2017. Calculated cost increment with diagnosis were: Intestinal obstruction: $94,738.08 (95%CI: $70,093.3, $117,294.2), Ventriculoperitoneal shunt: $86,456.60 (95%CI: $60,773.7, $111,552.2), Chronic Lung Disease $77,497.70 (95%CI: $74,937.2, $80,012.8), Intestinal perforation $57,997.15 (95%CI:$45,324.7, $70,652.6), Retinopathy of Prematurity: $55,761.80 (95%CI: $53,916.2, $57,620.1), Patent Ductus Arteriosus $53,453.70 (95%CI: $51,206.9, $55692.7, Post-haemorrhagic ventriculomegaly $41,822.50 (95%CI: $34,590.4, $48,872.4), Necrotizing Enterocolitis $39,785 (95%CI: $35,728.9, $43,879), Meningitis $38,871.85 (95%CI: $25,272.7, $52,224.4), Late onset sepsis $32,954.20 (95%CI: $30,403.7, 35.515), Feeding difficulties $24,820.90 (95%CI: $22,553.3, $27,064.7), Pneumonia $23,781.70 (95%CI: $18,623.8, $28,881.6), Grade &gt;2 Intraventricular Haemorrhage $14,777.38 (95%CI: $9,821.7, $20,085.2). Adjusted generalized linear model of diagnoses as coefficients for cost confirmed significance and robustness of the model.ConclusionCost of care for preterm infant is expensive, and significantly increases with prematurity complication. Interventions to reduce those complications may enable resource allocation and better understanding of the needs of the neonatal health services.
Computational analysis to investigate the anti-rheumatic potential of plant-based small molecule inhibitor targeting tumor necrosis factor α
Authors: Rehman Sanaya , Bhatti Attya , John Peter 
Published: February 2023

Objective: This study aimed to assess the anti-rheumatic potential of Dodonaea viscosa and to evaluate its bioactive small molecules for their beneficial effects in the management of rheumatoid arthritis.Methods:In vitro bioactivity assays were performed to assess the healing potential of D. viscosa and statistical analysis was performed by using the linear regression technique. In silico analysis was performed to identify the key inhibitors of the disease to target TNF-α. The plant extract was prepared using ethanol solvent via the Soxhlet method. Phytochemical and bioactivity testing was performed. Gas chromatography–mass spectrometry (GC-MS) analysis was conducted for bioactive plant compounds. Disease-specific target was shortlisted by HUB gene analysis. Molecular docking and molecular dynamic simulations were run for validation of the results.Results: Phytochemical studies verified the presence of phenols, flavonoids, steroids, sterols, saponins, coumarins, tannins, and terpenoids. The significant antioxidant potential of plant extract was evaluated by the DPPH and Ferric Reducing Antioxidant Power (FRAP) assays, while the anti-inflammatory potential was evaluated by the protein denaturation and Human Red Blood Cell (HRBC) membrane stabilization assays. In silico studies revealed that nine of the 480 compounds found in D. viscosa (ethanol extract) had drug-like properties. Tumor necrosis factor alpha (TNF-α) was selected as a key disease gene through HUB gene analysis. Results of molecular docking and MD simulation analysis demonstrated that 4-(1-hydroxy-3-oxo-1H-isoindol-2-yl) benzoic acid (PubChemID 18873897), had the best binding affinity with TNF-α amongst all nine compounds.Conclusion: 4-(1-hydroxy-3-oxo-1H-isoindol-2-yl) benzoic acid (PubChemID 18873897), have the potential to be a good small molecule inhibitor of TNF-α against rheumatoid arthritis.
Persistence and fading of the cognitive and socio-emotional benefits of preschool education in a low-resource setting: Group differences and dose-dependent associations in longitudinal data from Vietnam
Authors: Dinh Phuong Thi Thu , Robinson Julie Ann 
Published: February 2023

IntroductionFour analytic approaches examined the effectiveness of preschool education in Vietnam, which provides a context in which national curricula and teaching standards for preschools and schools, high levels of preschool attendance, and fee subsidies for disadvantaged children, limit the heterogeneity in children’s experiences that often obscure the outcomes associated with preschool attendance.MethodsThe Young Lives Study provided longitudinal data on children’s receptive vocabulary, mathematics, and life satisfaction at 5, 8, 12, and 15 years of age, and on their self-concept and relationships at 12 and 15 years.ResultsThe first analysis found that children who attended preschool (n = 1,562 at 5 years of age) had larger vocabularies at 5, 8, 12, and 15 years, greater mathematics knowledge at 5, 8, and 12 years, and higher life satisfaction at 5 and 12 years of age than the small number of children who did not attend preschool (n = 164 at 5 years of age). The second, found that the dose of preschool education (hours per week × 4 × months) received by children who attended preschool was positively associated with their receptive vocabulary and mathematics scores at 5, 8, 12, and 15 years of age, and with their life satisfaction at 5 and 15 years of age. Although the magnitude of the effect for vocabulary declined over time, it remained stable for mathematics. The third analysis found that a high dose of preschool education allowed disadvantaged rural children to achieve comparable or better scores than their urban peers for receptive vocabulary at 8, 12, and 15 years, mathematics at 12 years, and life satisfaction at all ages. The final analysis found that even a low dose of preschool education improved rural children’s receptive vocabulary at 5, 8, and 15 years, and their numeracy/mathematics scores at 5, 8, and 12 years.DiscussionTogether, the results suggest that preschool attendance had a small but meaningful positive association with Vietnamese children’s cognitive skills and life satisfaction that persisted for at least 10 years. These findings provide insights into the scale, scope, and longevity of effects that can be achieved from scaled-up preschool programs under resource-constrained conditions.
Feasibility analysis of CT-guided thermal ablation of multiple pulmonary nodules combined with intraoperative biopsy
Authors: Shan Yu-Qing , Wang Hai-Yu , He Xiao-Ning , Jiang Shuang-Sheng , Wang Hui-Hui , Lin Fan-Xia 
Published: February 2023

PurposeTo analyze the safety and feasibility of computed tomography (CT)-guided thermal ablation of multiple pulmonary nodules combined with intraoperative biopsy.MethodsThe data of 431 patients with 540 lung nodules undergoing CT-guided biopsy or ablation were retrospectively analyzed. Biopsy-only group (A): 107 patients (107 lesions) received CT-guided percutaneous lung biopsy only; Ablation-only group (B): 117 cases (117 lesions) only received CT-guided thermal ablation; Single focal ablation combined with biopsy group (C): 103 patients (103 lesions) received CT-guided thermal ablation combined with intraoperative immediate biopsy; Multifocal ablation combined with biopsy group (D): 104 patients (213 lesions) received CT-guided thermal ablation combined with intraoperative biopsy. The success rate of this technique was calculated, the complications were recorded, and the positive rate of pathological diagnosis of the specimens was evaluated (the tissue specimens could be confirmed as positive by pathological diagnosis).ResultsAll 431 patients with pulmonary nodules successfully completed the operation, and the technical success rate was 100% (431/431). In group A, hemoptysis occurred in seven cases after operation, while no hemoptysis was observed in the other groups. Pneumothorax occurred in 8 cases in group A, 14 cases in group B, 11 cases in group C, and 13 cases in group D. Hydrothorax occurred in 4 cases in group A, 7 cases in group B, 5 cases in group C and 9 cases in group D, and there were no significant differences between the groups. The positive rate of pathological diagnosis was 84.1% (90/107) in group A, 81.5% (84/103) in group C, and 82.6% (176/213) in group D, and there was no significant difference among the groups (P &gt; 0.05). A total of 15 cases in group C and 23 cases in group D underwent gene testing and analysis, and the biopsy tissue samples all met quality control standards.ConclusionCT-guided thermal ablation of multiple pulmonary nodules combined with intraoperative biopsy does not prolong the length of hospital stay or increase the risk of postoperative complications. It can meet the requirements of clinical, pathological and genetic testing, and is safe and reliable.
Kemampuan Tendangan Lurus Maygery dalam Cabang Olahraga Karate pada Siswi Putri Kelas IX SMP Sila Chandra Batubulan Tahun Ajaran 2019/2020
Authors: Dewi Ni Gusti Ayu Gede Rosma Dewi , Laksana Anak Agung Ngurah Putra , Pranata I Gst.Ngh.Agung Cahya 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui kemampuan tendangan lurus maygery pada siswi putri kelas IX SMP Sila Chandra Batubulan. Jenis penelitian ini adalah kualitatif deskriptif. Adapun informan dalam penelitian ini adalah 6 informan yang terdiri dari 5 siswi putri kelas IX dan 1 informan guru penjaskes kelas IX SMP Sila Chandra Batubulan. Jenis data kualitatif dengan kata- kata tertulis dan sumber data yang digunakan dalam penelitian ini adalah sumber data primer dan sekunder. Sumber data primer yang digunakan dalam penelitian ini pengamatan dan perhitungan langsung, data skunder yang digunakan yaitu data wawancara dan kuesioner. Teknik pengumpulan data menggunakan triangulasi yaitu observasi, wawancara, dan kuesioner. Adapun analisis data yang digunakan yaitu analisis Miles dan Huberman yaitu analisis data model interaktif yang melalui langkah-langkah pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa belum maksimalnya kemampuan siswi putri dalam lurus maygery pada siswi putri yaitu kategori cukup. Dengan persentase hasil nilai observasi sebanyak 16 siswa (50%) berada di kategori baik dan sebanyak 16 siswa (50%) berada dalam kategori cukup. Hasil data wawancara menunjukkan belum maksimalnya proses pembelajaran karena factor penghambat. Hasil data kuesioner menunjukkan sebanyak 12 siswa (37,5%) dalam kategori baik dan sebanyak 20 siswa (62,5%) berada dalam kategori cukup.dari ketiga data tersebut mendapatkan hasil data yang belum maksimal dengan kategori cukup dalam kemampuan lurus maygery pada siswi putri kelas IX SMP Sila Chandra Batubulan.
Peningkatan Pembelajaran Lari Jarak Pendek melalui Pendekatan Bermain Lari Bola Keranjang pada Siswa Kelas III di SD Negeri 05 Karangtengah Tahun 2020
Authors: Daryani Dwi Desti , Bachtiar Bachtiar 
Published: February 2023

Improved short distance running learning through the playing basket ball approach to third grade students at state elementary school 05 Karangtengah. The background of this thesis writing is that teachers often place importance on results compared to the process so that students feel bored, bored and not excited when learning to run short distances. The problems that are the center of attention in this study are: Can learning through the playing basket ball approach improve learning outcomes for short distance running in grade III students at state elementary school 05 Karangtengah, Sukabumi Regency? The purpose of this study were: to determine the improvement of learning outcomes for short distance running through the playing basket ball approach to third grade students at state elementary school 05 Karangtengah. This assessment involved all third grade students at state elementary school 05 Karangtengah, who attended the study, amounting to 25 people with a composition of 15 female students and 10 male students. The data analysis technique used the assessment of the teacher activity observation sheet, the assessment of the student activity observation sheet, basic motion analysis instruments and practical tests. This research was conducted for seven weeks with one meeting to carry out the initial condition test (pre-cycle), six meetings with two meetings for the implementation of cycle I, two meetings for the implementation of cycle II, and two meetings for the implementation of cycle III. From the research results, it was concluded that through the play approach, learning to run short distances in students experienced a significant increase in each cycle as evidenced by the results of the evaluation test in the pre-cycle the highest score was 75, the lowest score was 50, the average was 62.6, the percentage of student completeness was 24. %. In cycle I the highest score was 75, the lowest score was 50, the average was 67.2, the percentage of student completeness was 52%. In the second cycle the highest score was 80, the lowest score was 55, the average was 71.6, the percentage of student completeness was 68%. In the third cycle the highest score was 90, the lowest score was 65, the average was 80.2, the percentage of student completeness was 88%. The results of the questionnaire analysis can be concluded that through the playing basket ball approach the students are more enthusiastic and do not feel bored and are active in the learning process of short distance running.
Pengaruh Tingkat Kecerdasan Emosional (EQ) terhadap Prestasi Pendidikan Jasmani Siswa Sekolah Menengah Atas D.I.Yogyakarta
Authors: Falaahudin Ardhika , Saputro Yulius Agung 
Published: February 2023

Di Sekolah Menengah Atas di Kota Yogykarta terdapat beberapa siswa yang masih memiliki pemusatan perhatian kurang baik dan masih membutuhkan waktu relatif lama dalam proses pemecahan masalah yang dihadapi pada saat proses belajar mengajar.. Kecerdasan emosional siswa diduga belum optimal, berdasarkan pengamatan peneliti keadaan emosional siswa masih labil karena dalam masa remaja, seperti kurang empati kepada orang lain, cenderung egois, dan sulit mengatur perasaan pada saat proses belajar mengajar berlangsung. Permasalahan faktor yang mempengaruhi prestasi belajar pendidikan jasmani, olahraga dan kesehatan yang dirasa penting untuk diteliti adalah kecerdasan emosional (EQ).Tujuan penelitian ini untuk mengetahui ada tidaknya pengaruh kecerdasan emosional terhadap prestasi belajar pendidikan jasmani. Penelitian menggunakan metode korelasional dengan pendekatan regresi sederhana.Penelitian ini menggunakan populasi siswa di SMA Negeri di Kota Yogyakarta dengan sampel kelas X ,XI, dan XII sebanyak 200 siswa.