bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resenha do livro “A BNCC na contramão do PNE 2014-2024: avaliação e perspectivas.”
Authors: Lima Tácyla Agum Theotonio de , Torres Juliana Rezende 
Published: April 2023

O texto trata de uma resenha sorbe o livro " A BNCC na contramão do PNE 2014-2024". organizado por Márcia Angela da S. Aguiar e Luiz Fernandes Dourado, a obra apresenta diversas contribuições para a discussão sobre as políticas curriculares no contexto da construção e anuência da BNCC. Este texto resulta do trabalho de dez autores que elaboraram um conjunto de relatos, reflexões e críticas sobre a BNCC e suas implicações em relação às demais políticas setoriais e ao Plano Nacional de Educação (PNE) – o que se deu no contexto da Conferência Nacional Popular de Educação 2018 (CONAPE 2018).
Is miR-21 A Therapeutic Target in Cardiovascular Disease?
Authors: Holland Antoinette , Enrick Molly , Diaz Arianna , Yin Liya 
Published: April 2023

Review
Is miR-21 A Therapeutic Target in Cardiovascular Disease?

Antoinette Holland, Molly Enrick, Arianna Diaz, and Liya Yin *

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Ohio 44272, USA.
* Correspondence: lyin@neomed.edu; Tel.: 330-325-6521; Fax: 330-325-5912

Received: 16 November 2022
Accepted: 29 November 2022
Published: 11 January 2023

Abstract: microRNA-21 (miR-21) serves a multitude of functions at the molecular level through its regulation of messenger RNA. Previous research has sparked interest in the role of miR-21 as a potential therapeutic target in cardiovascular diseases. miR-21 expression contributes to the differentiation, proliferation, and maturation of many cell types, such as fibroblasts, endothelial cells, cardiomyocytes, and endothelial progenitor cells. The function of miR-21 depends upon its expression level in the specific cell types and downstream targets, which determine cell fate. Under pathological conditions, the expression level of miR-21 is altered, leading to abnormal gene regulation of downstream signaling and cardiovascular diseases such as hypertension, cardiac hypertrophy and fibrosis, atherosclerosis, and heart failure. Agomirs or antagomirs can be introduced into the respective tissue type to reverse or stop the progression of the disease. Exosomes in the extracellular vesicles, which mediate many cellular events with high biocompatibility, have a high potential of efficiently delivering miR-21 to their targeted cells. The critical role of miR-21 in cardiovascular disease (CVD) is indisputable, but there are controversial reports on the function of miR-21 in the same disease. This discrepancy sparks interest in better understanding the role of miR-21 in different tissues under different stages of various diseases and the mechanism of how miR-21 inhibitors work.
A Minimally Invasive Approach for Cardiac Electrophysiology Studies in Mice
Authors: Zi Min , Abraham Sabu , D'souza Alicia , Hutchings David , Prehar Sukhpal , Wang Xin , Cartwright Elizabeth J 
Published: April 2023

Article
A Minimally Invasive Approach for Cardiac Electrophysiology Studies in Mice

Min Zi , * , Sabu Abraham , Alicia D'souza , David Hutchings , Sukhpal Prehar , Xin Wang , and Elizabeth J Cartwright

Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, United Kingdom
* Correspondence: min.zi@manchester.ac.uk

Received: 6 January 2023
Accepted: 9 February 2023
Published: 25 March 2023

Abstract: Atrial fibrillation and ventricular tachycardia are commonly seen in clinic. Different approaches have been developed to investigate underlying mechanisms. Transvenous approach (TA) is widely used for studies but has several drawbacks. We therefore developed a novel minimally invasive approach (MIA) for mechanistic studies. Study included 27 male C57BL/6J mice, 19 for MIA and 8 for TA. Under general anaesthesia, ECG was recorded. A key hole was made on the right first intercostal space by separating the intercostal muscles, followed by the exposure of the superior vena cava and the top of the atrium. An EPR-800 catheter was inserted vertically, perpendicular to the chest, for atrial pacing and flatly over the ventricles for ventricular pacing. Burst S1–S1 and decremental S1–S2 pacing protocols were performed to evaluate SA recovery time (SNRT), the atrioventricular node effective refractory period (AVN-ERP), Wenckebach period, ventricular ERP, and arrhythmia susceptibility. MIA was successfully performed in all 19 mice without any complications. One mouse died during TA due to venous rupture. Compared MIA with TA, surgical time were significantly shorter (P<0.0001). Wenckebach period was shorter as well (P<0.05). No difference was found in baseline sinus cycle length, SNRT, correct SNRT, AVN-ERP, ventricular ERP, and arrhythmia susceptibility (all P>0.05). The novel MIA outplays TA by providing similar outcomes of PES but consuming less time, demanding less surgical expertise, and reducing the potential of surgical complications. Given the minimal tissue injury, it also provides great potential as a recovery procedure for longitudinal study.
Recent Clinical Successes in Liposomal Nanomedicines
Authors: Gu Wenjie , Andrews Gavin P. , Tian Yiwei 
Published: April 2023

Review
Recent Clinical Successes in Liposomal Nanomedicines

Wenjie Gu , Gavin P. Andrews , and Yiwei Tian , *

School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
* Correspondence: y.tian@qub.ac.uk

Received: 19 December 2022
Accepted: 26 January 2023
Published: 3 February 2023

Abstract: The intrinsic limitations of cancer therapies promoted the development of safer liposomal nanocarriers capable of better distributing the payload away from normal tissues. Since then, liposomal nanocarriers have been considered the primary drug delivery system for many active pharmaceutical ingredients. These systems are now frequently investigated for the treatment of many infectious diseases. Along with the tremendous progress in the anticancer and antifungal liposomal nanomedicines, we have also gradually realised the difficulties associated with the existing liposomal nanocarrier designs. A better understanding of the nanocarrier-bio interactions may provide a new paradigm in liposomal nanocarrier design and better clinical endpoint efficacy. This short review focuses on the progress and benefits of two market-approved liposomal nanomedicines for cancer and fungal treatments.
Ook letselschadeslachtoffers gebaat bij IPS-methode voor re-integratie
Authors: Audenaerde E.P. 
Published: April 2023

Ook letselschadeslachtoffers gebaat bij IPS-methode voor re-integratie
Het interventieprogramma IPS is een nog weinig bekend en daardoor weinig toegepaste interventie in de letselschadepraktijk. Het is een bewezen effectieve interventie voor mensen die kampen met een (ernstige) psychische aandoening. De aanpak is praktisch en gericht op arbeidsre-integratie. Hierbij geldt het credo dat werk het beste medicijn is. De begeleiding die vanuit het programma wordt ingezet, is intensief en doelgericht. Niet alleen de cliënt maar ook diens omgeving en de werkgever worden bij de begeleiding betrokken. Helaas staat het programma nu nog niet open voor cliënten die (nog) een werkgever hebben. Wellicht verandert dit in de toekomst. De doelgroep wordt verruimd. Er loopt een pilot waarin mensen met niet aangeboren hersenletsel volgens deze methode duurzaam worden gere-integreerd.
De franchiseovereenkomst zonder (zware eisen aan) knowhow
Authors: Dolphijn A.W. 
Published: April 2023

De franchiseovereenkomst zonder (zware eisen aan) knowhow
Voor de kwalificatie als franchiseovereenkomst vereist de Wet franchise dat sprake is van een franchiseformule waarvan knowhow een onderdeel is. Aan die knowhow worden in deze wet hoge eisen gesteld. Als aan deze vereisten niet voldaan wordt, is er geen sprake van een franchiseovereenkomst en missen de beschermende bepalingen van de Wet franchise toepassing. De vraag is waarom er dergelijke hoge eisen aan knowhow gesteld worden. Geconcludeerd wordt dat het bestanddeel van de noodzakelijk aanwezige ‘knowhow’ in de franchiseformule afgezwakt zou moeten worden, zodat de wettelijke definitie van de franchiseovereenkomst ruimer wordt.
Implementasi Algoritma Naive bayes dalam Klasifikasi Status Kesejahteraan Masyarakat Desa Gunungsari
Authors: Fauziah Nur Syifa , Dana Raditya Danar 
Published: April 2023

Kesejahteraan merupakan suatu pencapaian tatanan dalam kehidupan sosial, material, maupun spiritual yang diliputi oleh rasa keselamatan serta ketentraman lahir batin yang memungkinkan setiap individu masyarakat untuk melakukan usaha-usaha dalam memenuhi kebutuhan hidupnya guna mendapatkan kehidupan yang layak serta mampu mengembangkan dirinya dalam melaksanakan fungsi sosialnya. Pemerintah mempunyai peranan penting dalam mensejahterakan warganya, berbagai upaya pembangunan telah dilakukan oleh pemerintah dengan tujuan utama untuk mencapai kesejahteraan masyarakat melalui berbagai program pembangunan. Namun dalam pelaksanaannya dirasa kurang berjalan efektif, sering kali ditemukan kesalahan salah satunya dalam menentukan kelayakan penerima bantuan Dalam Implementasi pada Desa Gunungsari belum terdapatnya metode penilaian yang tepat dalam memastikan status kesejahteraan masyarakat. Konsep Data mining akan memudahkan dalam menangani permasalahan yang belum optimal salah satunya metode klasifikasi naive bayes yang mampu menciptakan model yang membedakan dalam memastikan status kesejahteraan masyarakat dengan memprediksi peluang di masa depan bergantung kepada kumpulan jenis data yang ada. Naive Bayes menghitung probabilitas bersumber pada kriteria- kriteria yang sudah ditetapkan. Metode ini menerapkan teknik supervised objek dengan menetapkan target kelas berdasarkan kategori sudah sejahtera dan belum sejahtera. Dari keseluruhan data yang berjumlah 1109 akan digunakan sebanyak 70% Sebagai data training, dan akan diuji sebanyak 30% menggunakan data testing. Variabel yang digunakan sebanyak 21 variabel. Hasil pengujian yang didapatkan menghasilkan akurasi sebesar 93,69 serta akurasi error sebesar 6,31%. Dengan adanya hasil prediksi kondisi penduduk setiap keluarga tersebut, diharapkan penelitian ini dapat memberikan informasi mengenai status kesejahteraan masyarakat dan dapat digunakan dalam membuat keputusan tepat dan akurat dan menjadi bahan pertimbangan yang bertujuan untuk kesejahteraan masyarakat.
Perancangan Standar Operasional Prosedur (SOP) Rekrutmen karyawan berbasis ISO 21001:2018 pada Universitas X di Tangerang Selatan.
Authors: Tirwan  
Published: April 2023

Dalam penelitian ini bertujuan untuk mengetahui efektifitas dari penyusunan Standar Operasional Prosedur (SOP) rekrutman tenaga pendidik dan kependidikan dengan menggunakan riskbased thinking berdasarkan ISO 21001:2018. Peneliitan ini dilakukan di satu universitas swasta di daerah Tangerang Selatan, Banten, dengan menggunakan acuan waktu antara tahun 2021 sampai tahun 2022. Pendekatan dalam penelitian ini, peneliti menggunakan metode kualitatif deskriptif. Adapun respondennya adalah pihak terkait yang ada di lingkungan kampus serta. Teknik pengumpulan data yang digunakan yaitu teknik wawancara, observasi, dan studi dokumentasi. Setelah data terkumpul dilakukan pengolahan data dengan cara menganalisa data yang ada, kemudian di interpretasikan dengan mengacu pada kerangka pikir penelitian.
Hasil penelitian ini menunjukkan bahwa SOP rekrutmen yang diintegrasikan dengan pemikiran berbasis risiko memberikan pengaruh yang cukup baik terhadap tingkat turnover karyawan. Keefektifitasan SOP rekrutmen yang mengintegrasikan riskbased thinking ini, dapat terlihat dari penurunan tingkat turnover karyawan selama kurun waktu 2022 akhir sampai dengan 2023 awal.
Demi perbaikan di masa mendatang, penulis menyarankan agar kegiatan perekrutan tenaga pendidik dan kependidikan di perguruan tinggi ini dilakukan dengan lebih mempertimbangkan aspek yang dapat meminimalisir turnover karyawan, baik karyawan lama ataupun karyawan baru, dan supaya lebih mempersiapkan rancanagan untuk proses perekrutan secara matang agar dapat memenuhi kebutuhan lembaga dengan maksimal dan sesuai dengan tujuan Pendidikan
Higher CSF/serum free‐T4 ratio is associated with improvement of quality of life during treatment with L‐thyroxine
Authors: Funkquist Anders , Wandt Birger , Blennow Kaj , Zetterberg Henrik , Svensson Johan , Bjellerup Per , Freund‐Levi Yvonne , Sjöberg Stefan 
Published: April 2023

AbstractUp to 20% of individuals with primary hypothyroidism treated with L‐thyroxine still suffer from severe symptoms. These are supposedly brain derived and involve both cognitive and emotional domains. Previously, no consistent relationship has been found between thyroid hormones (TH) or TSH levels in blood and quality of life (QoL). Recently, we reported an association between cerebrospinal fluid (CSF)/serum free‐thyroxine (f‐T4) ratio and QoL, in juvenile hypothyroid patients. Here, we investigated if CSF/serum f‐T4 ratio and QoL estimates correlate also during L‐thyroxine treatment. Moreover, the CSF biomarker neurogranin (Ng) was used as a biomarker for synaptic function and integrity in clinical research. Ng is partially controlled by TH and therefore we investigated the relationship between QoL parameters and Ng levels. Patients diagnosed with primary hypothyroidism were investigated using vital parameters, serum and CSF analyses of TH, TSH, Ng and QoL questionnaires. Similar procedures were performed after 6 months of treatment. The most marked associations with QoL were found for CSF/serum f‐T4 ratio, which was strongly related to several QoL parameters such as the mental subscore of SF‐36 (r = 0.83, p < .0005). Ng, which did not differ from that in our healthy controls, was lower in some patients during treatment and higher in others. However, the change in Ng during treatment was significantly correlated with QoL parameters including the mental subscore of SF‐36 (r = −0.86, p < .0001). In addition, the CSF/serum f‐T4 ratio correlated with the change in Ng (r = −0.75, p = .001). Our results suggest that the ratio between CSF and serum f‐T4 is an important biomarker for QoL during treatment of patients with primary hypothyroidism, so far in research, but in the future maybe also in clinical settings. Moreover, this ratio also correlates with the changes in Ng levels during L‐thyroxine treatment, further supporting the impact of the TH balance between serum and CSF on QoL.
Supplementary Tables from Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma
Authors: Zhang Gao , Wu Lawrence W. , Mender Ilgen , Barzily-Rokni Michal , Hammond Marc R. , Ope Omotayo , Cheng Chaoran , Vasilopoulos Themistoklis , Randell Sergio , Sadek Norah , Beroard Aurelie , Xiao Min , Tian Tian , Tan Jiufeng , Saeed Umar , Sugarman Eric , Krepler Clemens , Brafford Patricia , Sproesser Katrin , Murugan Sengottuvelan , Somasundaram Rajasekharan , Garman Bradley , Wubbenhorst Bradley , Woo Jonathan , Yin Xiangfan , Liu Qin , Frederick Dennie T. , Miao Benchun , Xu Wei , Karakousis Giorgos C. , Xu Xiaowei , Schuchter Lynn M. , Mitchell Tara C. , Kwong Lawrence N. , Amaravadi Ravi K. , Lu Yiling , Boland Genevieve M. , Wei Zhi , Nathanson Katherine , Herbig Utz , Mills Gordon B. , Flaherty Keith T. , Herlyn Meenhard , Shay Jerry W. 
Published: April 2023

<p>Table S1	Mean density values of crystal violet staining of 16 melanoma cell lines treated with 6-thio-dG and PLX4720. Table S2	RNA-seq data related to A375 cells treated with 6-thio-dG. Table S3	RNA-seq data related to A375 cells treated with BIBR 1532. Table S4	Apoptotic index and ssGSEA scores of 11 gene sets in 18 CCLE melanoma cell lines. Table S5	RPPA data related to A375 cells treated with 6-thio-dG. Table S6	Mean density values of crystal violet staining of 6 therapy-resistant melanoma cell lines treated with 6-thio-dG. Table S7	RPPA data related to the comparison between LOX-IMVI parental and BR cells. Table S8	RPPA data related to LOX-IMVI parental cells treated with 6-thio-dG. Table S9	RPPA data related to LOX-IMVI BR cells treated with 6-thio-dG. Table S10	RPPA data related to LOX-IMVI BR xenografts treated with 6-thio-dG. Table S11	The clinical information from patients with metastatic melanoma treated with immunotherapies.</p>
Table S 1, Figure S1, Figure S 2 from Molecular Lymph Node Status for Prognostic Stratification of Prostate Cancer Patients Undergoing Radical Prostatectomy with Extended Pelvic Lymph Node Dissection
Authors: Heck Matthias M. , Retz Margitta , Bandur Miriam , Souchay Marc , Vitzthum Elisabeth , Weirich Gregor , Schuster Tibor , Autenrieth Michael , Kübler Hubert , Maurer Tobias , Thalgott Mark , Herkommer Kathleen , Gschwend Jürgen E. , Nawroth Roman 
Published: April 2023

<p>Supplemental Table 1: A)	Multivariable analysis for the association with biochemical recurrence comparing histopathologic and molecular lymph node status as categorical variables excluding 7 patients receiving adjuvant treatment for pN1-disease B)	Multivariable analysis for the association with biochemical recurrence comparing histopathologic lymph node status and molecular maximum KLK3 expression in lymph nodes per patient as continuous variable excluding 7 patients receiving adjuvant treatment for pN1-disease Supplemental Figure 1: Distribution of the maximum KLK3 expression in lymph nodes per patient stratifying the study cohort in patients without lymph node metastases (pN0/molN0), patients with lymph node metastases detected exclusively by molecular analysis (pN0/molN1) or detected by both histopathologic and molecular analysis (pN1/molN1). Supplemental Figure 2: Biochemical recurrence-free survival according to lymph node status by (A) histopathology and (B) molecular analysis in a subgroup of 104 patients, who did not receive adjuvant treatment for pN1-status. Median biochemical recurrence-free survival was 3 months (95%CI 1.0-5.0) in 21 pN1-patients vs. not reached in 83 pN0-patients (p<0.001) and 18 months in 53 molN1-patients (95%CI 9.3-26.7) vs. not reached in 51 molN0-patients (p<0.001).</p>
Data from Dasatinib Plus Nutlin-3 Shows Synergistic Antileukemic Activity in Both p53<sup>wild-type</sup> and p53<sup>mutated</sup> B Chronic Lymphocytic Leukemias by Inhibiting the Akt Pathway
Authors: Zauli Giorgio , Voltan Rebecca , Bosco Raffaella , Melloni Elisabetta , Marmiroli Sandra , Rigolin Gian Matteo , Cuneo Antonio , Secchiero Paola 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> To analyze the effect of the combination of Dasatinib, a multikinase inhibitor, plus Nutlin-3, a nongenotoxic activator of the p53 pathway, in primary B chronic lymphocytic leukemia (B-CLL) patient samples and B leukemic cell line models.</p><p><b>Experimental Design:</b> The induction of cytotoxicity was evaluated in both primary B-CLL cell samples (<i>n</i> = 20) and in p53<sup>wild-type</sup> (EHEB, JVM-2) and p53<sup>deleted/mutated</sup> (MEC-2, BJAB) B leukemic cell lines. The role of Akt in modulating leukemic cell survival/apoptosis in response to Dasatinib or Dasatinib + Nutlin-3 was documented by functional experiments carried out using specific pharmacological inhibitors and by overexpression of membrane-targeted constitutively active form of Akt.</p><p><b>Results:</b> The combination of Dasatinib + Nutlin-3 exhibited a synergistic cytotoxicity in the majority (19 out of 20) of B-CLL samples, including patients carrying 17p- (<i>n</i> = 4), and in both p53<sup>wild-type</sup> and p53<sup>deleted/mutated</sup> B leukemic cell lines. At the molecular level, Dasatinib significantly counteracted the Nutlin-3-mediated induction of the p53 transcriptional targets <i>MDM2</i> and <i>p21</i> observed in p53<sup>wild-type</sup> leukemic cells. Conversely, Nutlin-3 did not interfere with the ability of Dasatinib to decrease the phosphorylation levels of ERK1/2, p38/MAPK, and Akt in both p53<sup>wild-type</sup> and p53<sup>deleted/mutated</sup> B leukemic cell lines. A critical role of Akt downregulation in mediating the antileukemic activity of Dasatinib and Dasatinib + Nutlin-3 was demonstrated in experiments carried out by specifically modulating the Akt pathway.</p><p><b>Conclusions:</b> These findings suggest that Dasatinib + Nutlin-3 might represent an innovative therapeutic combination for both p53<sup>wild-type</sup> and p53<sup>deleted/mutated</sup> B-CLL. <i>Clin Cancer Res; 17(4); 1–9. ©2010 AACR</i>.</p></div>
Direct Integration of Perovskite Solar Cells with Carbon Fiber Substrates
Authors: Game Onkar S. , Thornber Timothy , Cepero‐Mejías Fernando , Infante‐Ortega Luis C. , Togay Mustafa , Cassella Elena J. , Kilbride Rachel C. , Gordon Robert H. , Mullin Nic , Greenhalgh Rachael C. , Isherwood Patrick J. M. , Walls J. Michael , Fairclough J. Patrick A. , Lidzey David G. 
Published: April 2023

AbstractIntegrating photovoltaic devices onto the surface of carbon‐fiber‐reinforced polymer substrates should create materials with high mechanical strength that are also able to generate electrical power. Such devices are anticipated to find ready applications as structural, energy‐harvesting systems in both the automotive and aeronautical sectors. Here, the fabrication of triple‐cation perovskite n–i–p solar cells onto the surface of planarized carbon‐fiber‐reinforced polymer substrates is demonstrated, with devices utilizing a transparent top ITO contact. These devices also contain a “wrinkled” SiO2 interlayer placed between the device and substrate that alleviates thermally induced cracking of the bottom ITO layer. Devices are found to have a maximum stabilized power conversion efficiency of 14.5% and a specific power (power per weight) of 21.4 W g−1 (without encapsulation), making them highly suitable for mobile power applications.
Synthesis of 4‐Phosphinylpyrrolidin‐3‐ones via [3+2] Cycloaddition of Nitrones with Phosphinylallenes
Authors: Hammami Rayhane , Maldivi Pascale , Philouze Christian , Carret Sébastien , Darses Benjamin , Touil Soufiane , Poisson Jean‐François 
Published: April 2023

AbstractA variety of 4‐phosphinylpyrrolidin‐3‐ones was prepared via a [3+2] cycloaddition between aryl aldonitrones and phosphinylallenes. The products were isolated as unique 4,5‐trans diastereomers, in yields between 47% and 80%, over 23 examples. In the case of chiral racemic allenes, a 2:1 to 4:1 moderate 2,5‐diastereoselectivity was observed. Under the reaction conditions, the cycloadducts directly undergo a rearrangement to afford selectively the corresponding pyrrolidin‐3‐ones. DFT calculations provide some insights into the mechanism, involving the homolytic cleavage of the N−O bond of the cycloadduct.magnified image
Influence of Fe2O3‐FeS on the structure of iron‐containing clusters in aluminosilicate melts
Authors: Baoliang Xia , Facun Jiao , Lirui Mao , Yuanchun Zhang , Ying Xie , Hanxu Li 
Published: April 2023

AbstractIron compounds addition on the melt is a more complex issue. Uncertainties in industrial applications are caused by crystallization and depolymerization phenomena. Most of the current studies have discussed FeO and Fe2O3, ignoring the influence of FeS in the glass structure. This study designed and simulated artificial ash close to coal ash to interact with the glass melt at high temperatures. Coulomb titration, X‐ray diffraction (XRD), and Raman analyses were carried out to determine the percentage and composition of crystalline and noncrystalline materials in the glass. Samples of FeS‐Fe2O3 were subjected to the enumeration of the glass structure and quantitative calculations of the degree of polymerization. The results showed that 15‐wt% Fe2O3 promoted crystallization in the system and accelerates the depolymerization of FeS. The introduction of FeS increases the amorphous materials, and the obtained amorphous materials are Si dominated network structures and [SiO4]‐[FeO4]‐[SiO4] clusters. The network tends to change from [FeOn] and [AlO4] to [SiO4]. In addition, aluminosilicate may enter FeS particles and unreacted FeS may deposit on the aluminosilicate surface.