bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Inner Structure of STEVE‐Linked SAID
Authors: Mishin Evgeny V. , Streltsov Anatoly V. 
Published: April 2023

AbstractWe found the inner electromagnetic structure of subauroral ion drifts (SAID) in the SAID‐STEVE events documented by the Swarm spacecraft and numerically simulated the ionospheric feedback instability (IFI) development for one of the four similar events. Good quantitative agreement of the modeling results with the observed features shows that the ionospheric feedback mechanism captures their basic underlying physics. Simulations require nonlinear saturation of the IFI‐generated dispersive Alfvén waves. That is, a strong driving field of STEVE‐linked SAID with a deep density trough leads to a nonlinear system of dispersive Alfvén waves coupled with the density perturbation and parallel electric fields. As shown earlier, these fields produce the suprathermal electron population and energy balance necessary for the STEVE and Picket Fence radiation. Therefore, our results predict their inner structure.
Modeling the Climatology of Low‐ and Mid‐Latitude F‐Region Ionospheric Currents Using the Swarm Constellation
Authors: Fillion M. , Hulot G. , Alken P. , Chulliat A. 
Published: April 2023

AbstractWe present a new empirical model of quiet‐time F‐region ionospheric currents and associated magnetic fields. This model is designed to accurately represent these currents and fields at low and mid latitudes. For each individual Swarm satellite, the preprocessed data is represented as a non‐potential toroidal magnetic field using the Mie representation in a thin‐shell and spherical harmonic expansions. This approach allows to fully separate spatial and climatological variations as well as to assess the robustness of the model with respect to both measurement errors and data sampling with local time. The obtained model describes the toroidal magnetic fields and the associated radial poloidal electric currents at two distinct altitudes in the ionosphere F region. Clear signatures of low‐ and mid‐latitude interhemispheric field‐aligned currents (IHFACs) are identified. The model reproduces well‐known characteristics of the climatology of IHFACs and provides new insights, for example, on the average daily variations of IHFACs during winter in the Northern Hemisphere. It also well recovers the variations of IHFACs with longitude. The potential driving mechanisms of these variations, such as longitudinal variations of the main field and modulation by upward propagating atmospheric tides, are discussed. The new model can be used to analyze the relationship between atmospheric tides and IHFACs. It can also be used to investigate the connection between the magnetic fields and electric currents from the ionospheric E and F regions in order to improve the separation of these fields as well as our understanding of the overall ionospheric electric current system.
Ultra-low threshold continuous-wave quantum dot mini-BIC lasers
Authors: Zhong Hancheng , Yu Ying , Zheng Ziyang , Ding Zhengqing , Zhao Xuebo , Yang Jiawei , Wei Yuming , Chen Yingxin , Yu Siyuan 
Published: April 2023

AbstractHighly compact lasers with ultra-low threshold and single-mode continuous wave (CW) operation have been a long sought-after component for photonic integrated circuits (PICs). Photonic bound states in the continuum (BICs), due to their excellent ability of trapping light and enhancing light-matter interaction, have been investigated in lasing configurations combining various BIC cavities and optical gain materials. However, the realization of BIC laser with a highly compact size and an ultra-low CW threshold has remained elusive. We demonstrate room temperature CW BIC lasers in the 1310 nm O-band wavelength range, by fabricating a miniaturized BIC cavity in an InAs/GaAs epitaxial quantum dot (QD) gain membrane. By enabling effective trapping of both light and carriers in all three dimensions, ultra-low threshold of 12 μW (0.052 kW cm−2) is achieved at room temperature. Single-mode lasing is also realized in cavities as small as only 5 × 5 unit cells (~2.5 × 2.5 μm2 cavity size) with a mode volume of 1.16(λ/n)3. The maximum operation temperature reaches 70 °C with a characteristic temperature of T0 ~93.9 K. With its advantages in terms of a small footprint, ultra-low power consumption, and adaptability for integration, the mini-BIC lasers offer a perspective light source for future PICs aimed at high-capacity optical communications, sensing and quantum information.
A systematic review of neuroimaging epigenetic research: calling for an increased focus on development
Authors: Walton Esther , Baltramonaityte Vilte , Calhoun Vince , Heijmans Bastiaan T. , Thompson Paul M. , Cecil Charlotte A. M. 
Published: April 2023

AbstractEpigenetic mechanisms, such as DNA methylation (DNAm), have gained increasing attention as potential biomarkers and mechanisms underlying risk for neurodevelopmental, psychiatric and other brain-based disorders. Yet, surprisingly little is known about the extent to which DNAm is linked to individual differences in the brain itself, and how these associations may unfold across development – a time of life when many of these disorders emerge. Here, we systematically review evidence from the nascent field of Neuroimaging Epigenetics, combining structural or functional neuroimaging measures with DNAm, and the extent to which the developmental period (birth to adolescence) is represented in these studies. We identified 111 articles published between 2011–2021, out of which only a minority (21%) included samples under 18 years of age. Most studies were cross-sectional (85%), employed a candidate-gene approach (67%), and examined DNAm-brain associations in the context of health and behavioral outcomes (75%). Nearly half incorporated genetic data, and a fourth investigated environmental influences. Overall, studies support a link between peripheral DNAm and brain imaging measures, but there is little consistency in specific findings and it remains unclear whether DNAm markers present a cause, correlate or consequence of brain alterations. Overall, there is large heterogeneity in sample characteristics, peripheral tissue and brain outcome examined as well as the methods used. Sample sizes were generally low to moderate (median nall = 98, ndevelopmental = 80), and attempts at replication or meta-analysis were rare. Based on the strengths and weaknesses of existing studies, we propose three recommendations on how advance the field of Neuroimaging Epigenetics. We advocate for: (1) a greater focus on developmentally oriented research (i.e. pre-birth to adolescence); (2) the analysis of large, prospective, pediatric cohorts with repeated measures of DNAm and imaging to assess directionality; and (3) collaborative, interdisciplinary science to identify robust signals, triangulate findings and enhance translational potential.
The quality and content of websites in the UK advertising aligner therapy: are standards being met?
Authors: Alsaqabi Farah , Madadian Matin Ali , Pandis Nikolaos , Cobourne Martyn T. , Seehra Jadbinder 
Published: April 2023

AbstractAims To evaluate the quality of information and compliance with General Dental Council (GDC) ethical advertising guidelines for English-language orthodontic websites providing orthodontic treatment with aligners in the United Kingdom (UK).Materials and methods The term 'orthodontic aligners or braces' was entered into the Google online search engine. The first 100 English language orthodontic websites (practice or company) were pooled. Both the quality (DISCERN instrument) and compliance with GDC ethical advertising guidelines were assessed. Frequency distributions and the overall summative DISCERN score for each website were calculated.Results The overall mean DISCERN score was 42.9 (SD = 9.4). The quality of information was only rated as good-excellent for 16% of websites and only 11% of websites showed full compliance with GDC guidelines on ethical advertising. A link to the GDC/authority website (75%), the date when the website was last updated (72%), and the practice complaints policy (66%) were not commonly provided. The country of qualification, a statement of whether practices provide NHS or private treatment or a combination of both, and the date when the website was last updated, were significant predictors for the overall quality based on DISCERN score.Conclusions The quality of information provided on websites providing aligner therapy and their compliance with GDC guidelines on ethical advertising was suboptimal. An improvement in both areas is required.
Sirtuin 6 is a key contributor to gender differences in acute kidney injury
Authors: Miao Jinhua , Huang Jiewu , Liang Ye , Zhang Yunfang , Li Jiemei , Meng Ping , Shen Weiwei , Li Xiaolong , Wu Qinyu , Wang Xiaoxu , Niu Hongxin , Tang Ying , Zhou Shan , Zhou Lili 
Published: April 2023

AbstractAcute kidney injury (AKI) is rapidly increasing nowadays and at a high risk to progress into chronic kidney disease (CKD). Of note, men are more susceptive to AKI, suggesting gender differences in AKI patients. However, the underlying mechanisms remain largely unclear. To test it, we adopted two experimental models of AKI, including ischemia/reperfusion injury and rhabdomyolysis, which were constructed in age-matched male and female mice. We found severe damages of tubular apoptosis, mitochondrial dysfunction, and loss of renal function showing in male mice, while female mice only had very mild injury. We further tested the expression of Sirtuins, and found that female mice could preserve more Sirtuin members’ expression in case of kidney damage. Among Sirtuin family, Sirtuin 6 was maximally preserved in injured kidney in female mice, suggesting its important role involved in the gender differences of AKI pathogenesis. We then found that knockdown of androgen receptor (AR) attenuated tubular damage, mitochondrial dysfunction and retarded the loss of renal function. Overexpression of Sirtuin 6 also showed similar results. Furthermore, in cultured tubular cells, dihydrotestosterone (DHT) decreased Sirtuin 6 expression and exacerbated cell apoptosis. Ectopic expression of Sirtuin 6 sufficiently inhibited DHT-induced cell apoptosis. Mechanically, we found AR inhibited Sirtuin 6, leading to the repression of binding of Sirtuin 6 with PGC-1α. This resulted in acetylation of PGC-1α and inhibition of its activity, further triggered the loss of mitochondrial homeostasis. Our results provided new insights to the underlying mechanisms of gender differences in AKI, suggesting Sirtuin 6 maybe a new therapeutic target for preventing AKI in male patients.
The asymmetrical ESR1 signaling in muscle progenitor cells determines the progression of adolescent idiopathic scoliosis
Authors: Shao Xiexiang , Fu Xin , Yang Jingfan , Sui Wenyuan , Li Sheng , Yang Wenjun , Lin Xingzuan , Zhang Yuanyuan , Jia Minzhi , Liu Huan , Liu Wei , Han Lili , Yu Yang , Deng Yaolong , Zhang Tianyuan , Yang Junlin , Hu Ping 
Published: April 2023

AbstractAdolescent Idiopathic Scoliosis (AIS) is a common pediatric skeletal disease highly occurred in females. The pathogenesis of AIS has not been fully elucidated. Here, we reveal that ESR1 (Estrogen Receptor 1) expression declines in muscle stem/progenitor cells at the concave side of AIS patients. Furthermore, ESR1 is required for muscle stem/progenitor cell differentiation and disrupted ESR1 signaling leads to differentiation defects. The imbalance of ESR1 signaling in the para-spinal muscles induces scoliosis in mice, while reactivation of ESR1 signaling at the concave side by an FDA approved drug Raloxifene alleviates the curve progression. This work reveals that the asymmetric inactivation of ESR1 signaling is one of the causes of AIS. Reactivation of ESR1 signaling in para-spinal muscle by Raloxifene at the concave side could be a new strategy to treat AIS.
Two quasi-interfacial p-n junctions observed by a dual-irradiation system in perovskite solar cells
Authors: Omer Mohamed I. , Ye Tao , Li Xianqiang , Ma Shaoyang , Wu Dan , Wei Lei , Tang Xiaohong , Ramakrishna Seeram , Zhu Qiang , Xiong Shanxing , Xu Jianwei , Vijila Chellappan , Wang Xizu 
Published: April 2023

AbstractIn general, perovskite solar cells (PSC) with a sensitized or thin-film architecture absorb light from a single-side illumination, and carrier separation and transport only take place inside the active layer of the perovskite film. Herein, we demonstrated a dual-irradiation PSC system in which light passes through both the fluorinated tin oxide (FTO) side and the Au electrode side, resulting in much faster interfacial charge carrier extraction and transportation than that in a single-irradiation system, in which light passes through from either the FTO or semitransparent Au electrode side. This dual-irradiation PSC system with a configuration of FTO/Cl-TiO2/Mp-TiO2/mixed perovskite/spiro-OMeTAD/Au/ITO can form two quasi-interfacial p-n junctions, which occur separately at the interfaces of TiO2/perovskite and perovskite/spiro-OMeTAD. When the PSC device was illuminated simultaneously from both the FTO and Au/ITO sides, the PSC achieved a total power conversion efficiency (PCE) as high as 20.1% under high light intensity (1.4 sun), which is higher than PCE (18.4%) of a single-irradiation system. The time of flight (TOF) photoconductivity, small perturbation transient photovoltaic (TPV), finite-difference time-domain (FDTD) optical simulations, and dual illumination-side-dependent impedance spectroscopy (ISD-IS) were used to authenticate the presence of two quasi-interfacial p-n junctions in the PSC, creating more charge carriers than only one quasi p-n junction, and thus leading to a fast recombination process.
Mechanistic origins of corrosion protection of aluminum alloys by graphene/polyetherimide nanocomposite coatings
Authors: Sill Tiffany E. , Zaheer Wasif , Valdes Caroline G. , Balcorta Victor H. , Douglas Lacey , Fletcher Torrick , Steiger Sarah , Spinner Neil S. , Verkhoturov Stanislav V. , Kalyanaraman Viswanathan , Verghese Nikhil , Pharr Matt , Sheth Kapil , Davidson Rachel D. , Banerjee Sarbajit 
Published: April 2023

AbstractLight-weighting vehicular components through adoption of light-metal structural alloys holds promise for reducing the fuel consumption of internal combustion engine vehicles and increasing the range of battery electric vehicles. However, the alloyed microstructure and surface precipitates of aluminum alloys render these materials susceptible to corrosion under modest excursions from neutral pH. Traditional chromium-based anodic passivation layers are subject to increasingly stringent environmental regulations, whereas options for sacrificial cathodic films are sparse for electropositive metals. While hybrid nanocomposite coatings have shown initial promise, mechanistic underpinnings remain poorly understood. Here, a fully imidized polyetherimide (PEI) resin is utilized as the continuous phase with inclusion of unfunctionalized exfoliated graphite (UFG). A comprehensive investigation of the mechanisms of corrosion protection reveals key fundamental design principles underpinning corrosion inhibition. First, strong interfacial adhesion, which for PEI is facilitated by binding of imide carbonyl moieties to Lewis acidic sites on Al surfaces. Second, the miscibility of ion-impervious nanoscopic UFG fillers and stabilization of a substantial interphase region at UFG/PEI boundaries that result in minimizing the free volume at the filler/polymer interface. Finally, extended tortuosity of ion diffusion pathways imbued by the below-percolation-threshold 2D fillers. These three design principles help govern and modulate ion transport from electrolyte/coating interfaces to the coating/metal interface and are crucial for the extended preservation of barrier properties. The results suggest an approach to systematically activate multiple modes of corrosion inhibition through rational design of hybrid nanocomposite coatings across hard-to-abate sectors where light metal alloys are likely to play an increasingly prominent role.
Quantum error correction with gauge symmetries
Authors: Rajput Abhishek , Roggero Alessandro , Wiebe Nathan 
Published: April 2023

AbstractQuantum simulations of lattice gauge theories (LGTs) are often formulated on an enlarged Hilbert space containing both physical and unphysical sectors in order to retain a local Hamiltonian. We provide simple fault-tolerant procedures that exploit such redundancy by combining a phase flip error correction code with the Gauss’ law constraint to correct one-qubit errors for a $${{\mathbb{Z}}}_{2}$$

Z

2

or truncated U(1) LGT in 1+1 and 2+1 dimensions with a link flux cutoff of 1. Unlike existing work on detecting violations of Gauss’ law, our circuits are fault tolerant and the overall error correction scheme outperforms a naïve application of the [5, 1, 3] code. The constructions outlined can be extended to LGT systems with larger cutoffs and may be of use in understanding how to hybridize error correction and quantum simulation for LGTs in higher space-time dimensions and with different symmetry groups.
Optimal global spending for group A Streptococcus vaccine research and development
Authors: Tortorice Daniel , Ferranna Maddalena , Bloom David E. 
Published: April 2023

AbstractGroup A Streptococcus (Strep A) leads to 600,000 deaths and 600 million cases of pharyngitis annually. Although long a promising target for vaccine development, how much funding should be allocated to develop a Strep A vaccine is unclear. We aim to calculate the optimal amount of global spending for Strep A vaccine development, the resulting benefits, and the social rate of return on this spending. We develop a model of optimal spending, from a global societal perspective, on research and development (R&D) for vaccines and treatments. The model takes as inputs total harm from the disease, the probability an R&D project succeeds, the cost of a project, and the fraction of total harm a success alleviates. Based on these inputs the model outputs an optimal amount of spending and a rate of return. We calibrate the model for Strep A. Optimal spending is estimated to be 2020 USD33 billion. This spending leads to 2020 USD1.63 trillion in benefits and a real return of 22.3% per year for thirty years. Sensitivity shows an optimal spending range of 15.9 billion to 58.5 billion, a benefits range of 1.6 trillion to 37.9 trillion, and a return range of 18.0–48.2%. Investment in a Strep A vaccine could create enormous benefits for comparatively little cost. It represents one of the highest return uses of public spending. Policy can promote Strep A vaccine development through direct funding of projects and by promoting financial mechanisms that allow the private sector to diversify its R&D investment.
Prevalence of comorbidities and their impact on survival among older adults with the five most common cancers in Taiwan: a population study
Authors: Chien Li-Hsin , Tseng Tzu-Jui , Chen Tzu-Yu , Chen Chung-Hsing , Chen Chia-Yu , Jiang Hsin-Fang , Tsai Fang-Yu , Ku Hsiu-Ying , Jiang Shih Sheng , Hsiung Chao A. , Liu Tsang-Wu , Chang I-Shou 
Published: April 2023

AbstractBecause of the cancer incidence increase and population aging in Taiwan, we aimed to assess the cancer prevalence, to summarize the comorbidities of older patients with the five most common cancers (i.e., breast, colorectal, liver, lung, and oral), and to develop a Taiwan cancer comorbidity index (TCCI) for studying their actual prognosis. The linkage of the Taiwan Cancer Registry, Cause of Death Database, and National Health Insurance Research Database was used. We followed the standard statistical learning steps to obtain a survival model with good discriminatory accuracy in predicting death due to noncancer causes, from which we obtained the TCCI and defined comorbidity levels. We reported the actual prognosis by age, stage, and comorbidity level. In Taiwan, cancer prevalence nearly doubled in 2004–2014, and comorbidities were common among older patients. Stage was the major predictor of patients' actual prognoses. For localized and regional breast, colorectal, and oral cancers, comorbidities correlated with noncancer-related deaths. Compared with the US, the chances of dying from comorbidities in Taiwan were lower and the chances of dying from cancer were higher for breast, colorectal, and male lung cancers. These actual prognoses could help clinicians and patients in treatment decision-making and help policymakers in resource planning.
Post-hoc analysis of the safety and efficacy of isavuconazole in older patients with invasive fungal disease from the VITAL and SECURE studies
Authors: Hamed Kamal , Engelhardt Marc , Kovanda Laura L. , Huang Jin Ju , Yan Jean , Aram Jalal A. 
Published: April 2023

AbstractIsavuconazole is a triazole with broad-spectrum antifungal activity. In this post-hoc analysis of two prospective clinical trials (VITAL and SECURE), the safety and efficacy of isavuconazole in patients aged ≥ 65 years with invasive fungal diseases were evaluated. Patients were divided into two subgroups (≥ 65 and < 65 years). Adverse events (AEs); all-cause mortality; and overall, clinical, mycological, and radiological response were assessed. A total of 155 patients ≥ 65 years were enrolled in both trials. Most patients reported AEs. In the isavuconazole arm of both studies, serious AEs (SAEs) were greater in patients ≥ 65 versus < 65 years: 76.7% versus 56.9% (VITAL); 61.9% versus 49.0% (SECURE). In SECURE, SAE rates were similar in the ≥ 65 years subgroup of both treatment arms (61.9% vs 58.1%), while in the < 65 years subgroup the SAE rate was lower in the isavuconazole arm (49.0% vs 57.4%). In VITAL, all-cause mortality through day 42 (30.0% vs 13.8%) was higher, and overall response at end of treatment (27.6% vs 46.8%) was lower in patients ≥ 65 years versus < 65 years. In SECURE, all-cause mortality was similar between both subgroups, and isavuconazole (20.6% vs 17.9%) and voriconazole (22.6% vs 19.4%) treatment arms. The overall response was lower in the ≥ 65 years than the < 65 years subgroup in the isavuconazole (23.7% vs 39.0%) and voriconazole (32.0% vs 37.5%) arms. The safety and efficacy of isavuconazole were better in patients < 65 versus ≥ 65 years, and the safety profile was more favorable than that of voriconazole in both subgroups.Clinicaltrials.gov identifier NCT00634049 and NCT00412893.