bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric properties of the Greek versions of the Pandemic-Related Pregnancy Stress Scale and the Pandemic-Related Postpartum Stress Scale and associated risk factors during the second year of the COVID-19 pandemic
Authors: Siafaka Vassiliki , Tsonis Orestis , Christogiannis Christos , Kontouli Katerina-Maria , Margariti Kalypso , Barbalia Zoe , Flindris Stefanos , Manifava Eleni , Paschopoulou Kasmiria Ioanna , Tzioras Spyros , Baltogianni Maria , Mavridis Dimitris , Paschopoulos Minas 
Published: February 2023

Background
The COVID-19 pandemic has affected perinatal mental health. Reliable tools are needed to assess perinatal stress during pandemic situations.

Aims
To assess the psychometric properties of the Greek versions of the Pandemic-Related Pregnancy Stress Scale (PREPS) and the Pandemic-Related Postpartum Stress Scale (PREPS-PP) and to explore the associations between women's characteristics and perinatal stress during the second pandemic wave.

Methods
The PREPS and PREPS-PP were completed by 264 pregnant and 188 postpartum women, respectively, who also completed the State-Trait Anxiety Inventory (STAI) and the Edinburgh Perinatal Depression Scale (EPDS).

Results
The internal consistency was similar for PREPS and PREPS-PP. It was good for preparedness stress (a = 0.77 and α = 0.71, respectively) and infection stress (α = 0.83 for both scales) but low for positive appraisal (α = 0.46 and α = 0.41, respectively). Of the pregnant women, 55.33% and 55.27%, respectively, reported scores of ≥40 on STAI-S and STAI-T, and the respective percentages for the postpartum women were 47.34% and 46.80%. In addition, 14.39% of the pregnant women and 20.74% of the postpartum women scored ≥13 on the EPDS. Higher preparedness stress on PREPS and PREPS-PP was associated with primiparity (P = 0.022 and P = 0.021, respectively) and disrupted perinatal care (P = 0.069 and P = 0.007, respectively). In postpartum women, higher infection stress was associated with chronic disease (P = 0.037), primiparity (P = 0.02) and perceived risk of infection (P = 0.065). Higher score on infection stress was associated with disrupted perinatal care in both groups (P = 0.107 and P = 0.010, respectively).

Conclusions
The Greek versions of PREPS and PREPS-PP are valid tools for the assessment of women at risk of perinatal stress during a health crisis.
Consistency Between State's Cancer Registry and All-Payer Claims Database in Documented Radiation Therapy Among Patients Who Received Breast Conservative Surgery
Authors: Li Chenghui , Malapati Sindhu J. , Guire John T. , Hutchins Laura F. 
Published: February 2023

PURPOSE Arkansas is one of only four known states that have linked All-Payer Claims Database (APCD) to state's cancer registry (Arkansas Cancer Registry [ACR]). We evaluated the reporting consistency of radiation therapy (RT) between the two sources. METHODS Women age ≥ 18 years diagnosed in 2013-2017 with early-stage hormone receptor–positive breast cancer who received breast-conserving surgery were identified. Patients must have continuous insurance coverage (any private plans, Medicaid, and Medicare) in the 13 months (month of diagnosis and 12 months after). Receipt of RT was identified independently from ACR and APCD. We calculated sensitivity, specificity, positive predictive value, and negative predictive value for receipt of RT coded by the registry compared with APCD billing claims as the gold standard. We assessed the degree of concordance between the data sources by Cohen's kappa statistics. RESULTS The final sample included 2,695 patients who were in both databases and satisfied our inclusion/exclusion criteria. Using APCD as the gold standard, there were high sensitivity (88.1%) and positive predictive value (87.7%) and moderate specificity (71.1%) and negative predictive value (71.8%). The overall agreement between the two sources was 83.0%, with a kappa statistic of 0.59 (95% CI, 0.56 to 0.63). Consistency measures varied by age, stage, and insurance type with Medicare fee-for-service coverage only having the best and private insurance only the worse consistency. CONCLUSION In patients with early-stage hormone receptor–positive breast cancer who received breast-conserving surgery, recording of RT receipt was moderately consistent between Arkansas APCD and ACR. Future studies are needed to identify factors affecting reporting consistency to better use this unique resource in addressing population health problems.
Genomic Complexity as a Biomarker to De-Escalate Adjuvant Imatinib Treatment in High-Risk Gastrointestinal Stromal Tumor
Authors: Boye Kjetil , Gorunova Ludmila , Gunawan Bastian , Hompland Ivar , Sander Bjoern , Panagopoulos Ioannis , Langer Claus , Golas Monika , Heim Sverre , Füzesi László , Hølmebakk Toto , Micci Francesca 
Published: February 2023

PURPOSE Adjuvant imatinib treatment is recommended for patients with localized gastrointestinal stromal tumor (GIST) at high risk of recurrence. Almost half of high-risk patients are cured by surgery alone, indicating a need for improved selection of patients for adjuvant therapy. The aim of this study was to investigate if genomic tumor complexity could be used as a prognostic biomarker. METHODS The discovery cohort consisted of patients who underwent resection of primary GIST at Oslo University Hospital between 1998 and 2020. Karyotypes were categorized as simple if they had ≤ 5 chromosomal changes and complex if there were > 5 chromosomal aberrations. Validation was performed in an independent patient cohort where chromosomal imbalances were mapped using comparative genomic hybridization. RESULTS Chromosomal aberrations were detected in 206 tumors, of which 76 had a complex karyotype. The most frequently observed changes were losses at 14q, 22q, 1p, and 15q. The 5-year recurrence-free survival (RFS) in patients classified as very low, low, or intermediate risk was 99%. High-risk patients with a simple tumor karyotype had an estimated 5-year RFS of 94%, and patients with a complex karyotype had an estimated 5-year RFS of 51%. A complex karyotype was associated with poor RFS in patients with and without adjuvant imatinib treatment and in multivariable analysis adjusted for tumor site, size, mitotic count, and rupture. The prognostic impact of genomic complexity was confirmed in the validation cohort. In both cohorts, the 5-year disease-specific survival was > 90% for high-risk patients with genomically simple tumors. CONCLUSION Genomic tumor complexity is an independent prognostic biomarker in localized, high-risk GIST. Recurrences were infrequent for tumors with simple karyotypes. De-escalation of adjuvant imatinib treatment should be explored in patients with cytogenetically simple GISTs.
Dearth of ICD Codes for Complications of Immune Checkpoint Inhibitors Impedes Clinical Care and Research
Authors: Cheung Yee-Ming M , Hamnvik Ole-Petter R , Shariff Afreen , Gallagher Emily J 
Published: February 2023

AbstractImmune checkpoint inhibitors (ICIs) are a rapidly expanding class of targeted therapies effective in the treatment of various cancers. However, while efficacious, ICIs have been associated with treatment complications, namely immune-related adverse events (irAEs). IrAEs of the endocrine system are among the most commonly reported irAEs, but despite their high incidence, standardized disease definitions and endocrine IrAE-specific International Classification of Diseases (ICD) codes remain lacking. This dearth of standardized nomenclature and ICD codes has in many ways impeded both the clinical care of patients and the progress of endocrine irAE-related research. ICD codes are used internationally and are essential for medical claims reporting in the health care setting, and they provide a universal language system for recording, reporting, and monitoring diseases. These codes are also a well-accepted form of electronic health record data capture that facilitates the collection, storage, and sharing of data. Therefore, the lack of standardized disease definitions and ICD codes has been associated with misclassification and suboptimal management of individuals with endocrine irAEs and has also been associated with reduced data availability, comparability, and quality. Harmonized and clinically relevant disease definitions along with the subsequent development of endocrine-irAE-specific ICD codes will provide a systematic approach to understanding the spectrum and burden of endocrine irAE diseases, and will have a positive effect across clinical, public health, and research settings.
Maré cohort-profile: a prospective cohort study based in a socially vulnerable community during the COVID-19 pandemic in Rio de Janeiro, Brazil
Authors: A Batista-da-Silva Amanda , T Ranzani Olivia , M de Paulo Daniela , L Braunstein Mariana , R Bozza Helena , Fischer Ronald , V Ramos Grazielle , M C Dias Carolina , P da Silva Everton , E Arouca Luna , L S Bastos Leonardo , T Ranzani Otavio , Hamacher Silvio , A Bozza Fernando 
Published: February 2023

Background: Socially vulnerable populations were vastly affected by the COVID-19 pandemic. The pandemic significantly impacted Brazil, pressuring its healthcare system for several months, with high mortality rates, even among the youngest population. Cohort studies combining disease surveillance are essential for understanding virus circulation in the community, surrogates of protection, vaccine effectiveness, and demand for health resources. Methods: Here, we present the protocol for a community-based prospective cohort study in the largest complex of favelas (slums) in Rio de Janeiro, Brazil (Complexo da Maré). The study participants are residents initially recruited during a massive vaccination campaign in the community. Five waves of data collection at approximately six-month intervals were planned. The first two waves have been completed at the time of writing this study protocol, and the third is underway. The protocol comprises interviews, blood sampling, and records linkage with secondary data to enrich the profiles of cohort participants and community information. We will describe COVID-19 seroprevalence, socio-demographic characteristics, and the burden of COVID-19, followed by estimating the association of socioeconomic factors and the burden of disease with seroprevalence. Discussion: The primary aims of the study are to assess COVID-19 clinical, epidemiological and genomic profiles and outcomes in residents from Maré, including vaccine effectiveness, surrogates of immune protection, virus transmission in households, and the overall burden of the pandemic.
Mozolne początki zmagań o ochronę zabytków w Galicji. Rozważania na marginesie najnowszej książki Tadeusza Łopatkiewicza
Authors: Laskowski Andrzej 
Published: February 2023

Artykuł zawiera rozważania na temat procesu rodzenia się i powolnego dojrzewania systemu ochrony zabytków w Galicji, jednym z krajów koronnych monarchii habsburskiej, zachodzącego w latach 60. i 70. XIX wieku. Jedną z kluczowym postaci tego czasu był Ludwik Mieczysław Lubicz Potocki, konserwator zabytków działający na terenie Galicji Wschodniej, obejmujący swoim działaniem 49 ówczesnych powiatów politycznych, w tym m.in. miasto Krosno i jego okolice. Punktem wyjścia do rozważań jest najnowsza (wydana w 2022 roku) książka autorstwa Tadeusza Łopatkiewicza poświęcona postaci tego konserwatora i jego działalności na terenie Krosna i okolic.
Wspomniana książka przybliża postać samego konserwatora i koleje jego życia (ostatni rozdział), pokazuje tło, na jakim przyszło mu wzrastać, zdobywać wykształcenie i podejmować współpracę w zakresie odkrywania i interpretacji śladów przeszłości (rozdział pierwszy), prezentuje zręby rodzącego się systemu ochrony zabytków w monarchii habsburskiej, w tym w Galicji (rozdział drugi) oraz – co najważniejsze – w oparciu o odnalezione źródła przedstawia i precyzyjnie objaśnia dorobek Potockiego w zakresie urzędowej opieki nad zabytkami Galicji Wschodniej, ze szczególnym uwzględnieniem zabytków Krosna i okolic. Pracę uzupełniają: aneks źródłowy, bibliografia, indeksy i streszczenie w języku angielskim.
Publikacja autorstwa Tadeusza Łopatkiewicza, owoc jego wieloletnich badań oraz poszukiwań archiwalnych i bibliotecznych, stanowi istotny przyczynek do nowej syntezy dziejów konserwatorstwa polskiego i ochrony zabytków na ziemiach Polski w XIX wieku. Elementem szczególnie cennym, odnalezionym przez autora książki i wykorzystanym pod kątem badanego miasta i jego okolic, jest Dziennik konserwatorski Potockiego, spisywany w latach 1866–1878, na kartach którego uwidaczniają się wszystkie blaski i cienie pracy ówczesnego konserwatora, znakomicie wydobyte i skomentowane przez Tadeusza Łopatkiewicza. Jest rzeczą konieczną, aby w najbliższym czasie źródło to zostało opublikowane i zinterpretowane w całości, najlepiej dzięki współpracy grona badaczy bliżej zajmujących się w ostatnim czasie osobą Ludwika Mieczysława Lubicz Potockiego, w tym Tadeusza Łopatkiewicza.
Association of сarriage of the rs4646994 polymorphism of the ACE gene with obesity and androgen deficiency in men
Authors: Mosalev K. I. , Yankovskaya S. V. , Ivanov I. D. , Pinkhasov B. B. , Selyatitskaya V. G. 
Published: February 2023

BACKGROUND: Obesity and androgen deficiency (AnD) are characterized by similar disturbances in metabolic parameters, the presence of signs of insulin resistance, metabolic syndrome, the risk of developing cardiovascular diseases (CVD) and vascular complications. These facts indicate the possibility of the presence of common mechanisms that determine the predisposition to the development of obesity and AnD, which may include genetic factors, in particular, the rs4646994 polymorphism of the ACE gene, which, according to recent data, is associated with the risk of developing CVD, hypertension, and obesity.AIM: To study the association of the carriage of polymorphic variants of the rs4646994 locus of the ACE gene with the features of anthropometric and androgenic status in men.MATERIALS AND METHODS: In the period from April 2020 to October 2021 there were observed male patients aged 18–75 years old, who were hospitalized in a therapeutic hospital because of comorbid somatic pathology (hypertension, coronary heart disease, dorsopathy, vegetative-vascular dystonia, gastroesophageal reflux disease, and others). Anthropometry, a study of the content of hormones of the reproductive system in the blood serum using enzyme-linked immunosorbent assay (ELISA), as well as a genetic study for the carriage of polymorphic variants of the rs4646994 locus of the ACE gene by the polymerase chain reaction (PCR) method, followed by electrophoresis of PCR products, were carried out. RESULTS: 82 patients took part in research. According to the results of genetic analysis, 17 people were assigned to the group of homozygotes for the wild type (I/I, G1), 41 people were assigned to the group of heterozygotes (I/D, G2), and 41 people were assigned to the group of homozygotes for the mutant allele (D/D, G3) 24 people. Body weight, chest circumference, waist and hips, body mass index in patients carrying the D allele of the rs4646994 polymorphism were statistically significantly higher than in I/I homozygotes. Differences in hormonal status also turned out to be statistically significant: patients from G1 compared with G2 and G3 had higher levels of total testosterone; from G1 compared to G3 — a higher level of free testosterone.CONCLUSION: An association of the carriage of the D allele of the rs4646994 polymorphic locus of the ACE gene with overweight and ADI was revealed.
Hypertensive disorders of pregnancy and severe acute respiratory syndrome coronavirus-2 infection
Authors: Wetcher Cara S. , Gulersen Moti , Rochelson Burton , Shan Weiwei , Bornstein Eran , Blitz Matthew J. 
Published: February 2023

Abstract

Objectives
We aimed to determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with an increased risk of hypertensive disorders of pregnancy (HDP).

Methods
A multicenter retrospective cohort study of all pregnant patients who had SARS-CoV-2 testing and delivered in a large health system between March 2020 and March 2021. Cases were stratified into two groups: patients who tested positive for SARS-CoV-2 during pregnancy vs. patients who tested negative. The primary outcome of HDP, defined as a composite of gestational hypertension, preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP Syndrome), and eclampsia by standard criteria, was compared between the two groups. Statistical analysis included multivariable logistic regression to adjust for potential confounders such as maternal demographics and comorbidities. Patient ZIP codes were linked to neighborhood-level data from the US Census Bureau’s American Community Survey.

Results
Of the 22,438 patients included, 1,653 (7.4%) tested positive for SARS-CoV-2 infection. Baseline demographics such as age, body mass index, race, ethnicity, insurance type, neighborhood-built environmental and socioeconomic status, nulliparity, and pregestational diabetes differed significantly between the two groups. SARS-CoV- 2 infection in pregnancy was not associated with an increased risk of HDP compared to those without infection (14.9 vs. 14.8%; aOR 1.06 95% CI 0.90–1.24).

Conclusions
In this large cohort that included a universally-tested population with several socioeconomic indicators, SARS-CoV-2 infection in pregnancy was not associated with an increased risk of HDP.
Contesting Digital Technology through New Forms of Transnational Activism
Authors: Webster Edward , Ludwig Carmen 
Published: February 2023

While the tech giants are using privatisation to present themselves as providers of solutions to global problems, digitalisation is creating new forms of transnational activism. Global unions are emerging as players in this contest, helping to build counter power at both the local and global level. Through a comparison of the use of digital technology in two case studies in Africa involving two different global unions the article demonstrates how global unions can, through their intermediary coordinating role at the supranational level, deepen worker power.
KEYWORDS: Global unions; digital technology; informal work; power resources; union revitalisation
Linear Viscoelastic Limit Determination and Modeling for Binders with Physical Hardening Effects
Authors: Isa Nuh , Mangiafico Salvatore , Sauzéat Cédric , Phan Alexiane 
Published: February 2023

Abstract
The objective of this research is to study the limit of linear viscoelastic behavior on a common straight-run bituminous binder at different temperatures and frequencies by performing strain amplitude sweep tests. A dynamic shear rheometer was used for the experimental campaign. An increase of complex modulus due to physical hardening was observed during strain amplitude sweep tests at low temperatures and frequencies. A correction method is proposed to consider the effect of physical hardening on complex modulus when evaluating the linear viscoelastic limit.
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary
Authors: Brundu Serena , Napolitano Virginia , Franzolin Giulia , Lo Cascio Ettore , Mastrantonio Roberta , Sardo Gabriele , Cascardi Eliano , Verginelli Federica , Sarnataro Sergio , Gambardella Gennaro , Pisacane Alberto , Arcovito Alessandro , Boccaccio Carla , Comoglio Paolo M , Giraudo Enrico , Tamagnone Luca 
Published: February 2023

AbstractThe genetic changes sustaining the development of cancers of unknown primary (CUP) remain elusive. The whole‐exome genomic profiling of 14 rigorously selected CUP samples did not reveal specific recurring mutation in known driver genes. However, by comparing the mutational landscape of CUPs with that of most other human tumor types, it emerged a consistent enrichment of changes in genes belonging to the axon guidance KEGG pathway. In particular, G842C mutation of PlexinB2 (PlxnB2) was predicted to be activating. Indeed, knocking down the mutated, but not the wild‐type, PlxnB2 in CUP stem cells resulted in the impairment of self‐renewal and proliferation in culture, as well as tumorigenic capacity in mice. Conversely, the genetic transfer of G842C‐PlxnB2 was sufficient to promote CUP stem cell proliferation and tumorigenesis in mice. Notably, G842C‐PlxnB2 expression in CUP cells was associated with basal EGFR phosphorylation, and EGFR blockade impaired the viability of CUP cells reliant on the mutated receptor. Moreover, the mutated PlxnB2 elicited CUP cell invasiveness, blocked by EGFR inhibitor treatment. In sum, we found that a novel activating mutation of the axon guidance gene PLXNB2 sustains proliferative autonomy and confers invasive properties to stem cells isolated from cancers of unknown primary, in EGFR‐dependent manner.
Salud mental y actividades vitales en desplazados por la violencia en Villas de Aranjuez con el modelo de vida Roper-Logan-Tierney
Authors: Barrios Puerta Zorayda , Orgulloso Bautista Claudia Alejandra , Del Toro Rubio Moraima 
Published: February 2023

Objetivo: Describir el estado de salud mental y las actividades vitales en desplazados del barrio Villas de Aranjuez de la ciudad de Cartagena basado en la teoría de Nancy Roper en el año 2017.Materiales y Métodos: Se realizó un estudio de tipo observacional, descriptivo de corte transversal con una población de 1.700 desplazados albergados en 2.500 viviendas de interés social en el barrio villas de Aranjuez (Cartagena), la muestra fue de 350 individuos, se les aplicó una encuesta estructurada y se realizó un análisis descriptivo a través del reporte de frecuencias absolutas y porcentajes. Resultados: Los desplazados fueron principalmente femeninos un 74% (259), con 30 a 39 años un 30,6% (107), conviven en unión libre 55,1% (193), católicos un 48,3% (169), bachilleres un 47,4% (166), trabajadores un 47,1% (165). El desplazamiento ocurrió entre 2000-2002 en un 43,1% (151), ocurriendo esto por amenaza personal o familiar en un 33,7% (118), por grupos paramilitares en un 56,3% (197) y por la guerrilla un 36,6% (128). Por lo tanto, los posibles cambios en la salud mental que la población presentó por la condición de desplazamiento fueron en su modo de vida en un 93,4% (241), la tristeza y el desasosiego en un 91,9% (237) y estrés en un 81,4% (210). Las actividades vitales no se han visto alterado entre la gran mayoría de esta población (normales en >90% de desplazados). Conclusiones: Los cambios negativos sobre la salud mental de los desplazados se dan entre aquellos que han padecido abusos sexuales y agresiones de tipo físico. En especial la presencia de tristeza y desasosiego, sensación de estrés y de abandono de parte del estado, sin embargo, las actividades vitales en general resultaron ser normales.