bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of Violence and Mental Health Outcomes Before and During the COVID-19 Pandemic: Characterizing Vulnerability in Sexual and Gender Minority College Students
Authors: Deng Wisteria , Xie Hui , Creighton Mackenzie , Lin Yezhe 
Published: February 2023

Abstract
Background. Lockdown measures and remote learning during the COVID-19 pandemic have had a large impact on the physical and mental health of college students, especially those with minority identities. Sexual and gender minority (SGM) students are especially at risk for sexual violence and subsequent adverse mental health outcomes on campus. It is worth examining how pandemic-related changes on campus may pose differential types of threat to SGM college students. The present study aimed to juxtapose patterns of violence among college students before and during the pandemic, and explore the risks and consequences of violence/assaults among minority groups.
Methods. The study utilizes the 2018-2019 and 2020-2021 Healthy Minds Study (HMS) datasets. The HMS is a web-based survey data focuses on mental health, health behavior, campus climates and related issues among a nationally representative sample of undergraduate and graduate students from 60 U.S. campuses.
Results. Results demonstrated that violence committed by strangers/acquaintances decreased during the pandemic for all college students, while sexual assaults by ex or current partners remained unchanged.Further, SGM students experienced increased sexual violence and adverse mental health outcomes during the pandemic.
Limitations. While the two cohorts in comparison were collected before and during the pandemic, they were not based on the same sample. Future research should collect longitudinal data to understand the impacts of sexual violence over time.
Conclusions. The present study serves as a starting point to understand the sexual violence and heightened mental health risk experienced by sexual and gender minority college students.
Reinforcement Learning Adaptive Risk-Sensitive Fault-Tolerant IGC Method for a Class of STT Missile with Non-Affine Characteristics, Stochastic Disturbance and Unknown Uncertainties
Authors: Wang Zheng , Hao Yuting 
Published: February 2023

Abstract

In this paper, a novel reinforcement learning adaptive risk-sensitive fault-tolerant stochastic non-affine integrated guidance and control (NAIGC) method is proposed for a class of skid-to-turn (STT) missiles. The cost standard of the risk-sensitive index we coveted can be arbitrarily small, ensured by solving a specific inequality. Firstly, an extended integration system is introduced to solve the challenging control problem posed by the non-affine form of the control signal, taking into account the non-affine nature in the missile. Secondly, for random noise and unknown non-linearities in NAIGC systems, a reinforcement learning actor-critic adaptive risk-sensitive control method is proposed to ensure the input-state stability of the system. Subsequently, hyperbolic tangent functions and adaptive boundary estimation are used to reduce disturbance-induced jitter and actuator fault-induced bias in the control system. In addition, the proposed control strategy improves the missile's interception performance against maneuvering targets and reduces the conservatism of existing adaptive robust control methods. Ultimately, not only is the stability of the NAIGC closed-loop system demonstrated using Lyapunov theory, but the effectiveness and superiority of the method is also verified through numerical simulations.
Tocilizumab for the Management of Glucocorticoid-Refractory Idiopathic Orbital Inflammation
Authors: Wang Ping , Guo Chen-jun , Zhang Shao-bo , Ning Xiao-Na , Ma Dan , Li Yang-jun 
Published: February 2023

Abstract
Background: To demonstrate the efficacy of the anti-interleukin-6 receptor monoclonal antibody tocilizumab in patients with glucocorticoid-refractory idiopathic orbital inflammation (IOI).
Patients and Methods: A retrospective, observational case series study on 16 (10 females, 6 male) consecutive patients treated with TCZ for glucocorticoid-refractory IOI between September 2020 and January 2022. Median follow-up was 14.0±4.68 months (range, 9-24 months). The mean age of the patients was 34.5±9.93 years (range, 19-60 years), All patients had been treated with glucocorticoid but condition is repeatedly reactivated when steroid tapering for 0.5-3 years. Each patient underwent ophthalmological examinations, laboratory tests, CT/MRI of orbit, and received the initiated treatment with a monthly dose of 8 mg/kg TCZ for 2 to 6 cycles. TCZ was withdrawn due to low disease activity. Patient-reported outcomes, clinician-reported outcomes, and CT/MRI findings of the orbit after treatment were collected at the follow-up to assess the response.
Results: Among the patients, 7 (44%) had myositis, 5 (31%) had diffuse IOI, 2 (13%) had dacryoadenitis, and 2 (13%) had anterior IOI. All patients (100%) had eyelid swelling and oppressive orbital pain, 12 (75%) had diplopia and ocular motility restriction, 9 (56%) had ptosis, and 1 (6%) had vision decline. After one treatment with TCZ, the eyelid swelling, ptosis, and orbital pain improved in all patients and completely relieved after all treatments. The average numeric pain rating scale score of all patients was 4.88±2.18 (range, 2-9) and dropped to 0 before and after TCZ treatment respectively (P<0.01). At the last TCZ treatment, the diplopia had resolved in 67% (8/12) patients and significantly reduced in 33% (4/12) patients who had orbital biopsy operations or external beam radiotherapy history; the vision of the patient with the most serious diffuse IOI was improved from 0.1 to 1.0; 11 patients with single or multiple enlarged extraocular muscles showed a significant CT/MRI reduction of the orbital lesion and a stable clinical improvement for the follow-up time of observation. To date, no recurrence was occurred and no side effects of TCZ have been reported.
Conclusion: TCZ can reduce orbital pain, eyelid swelling, muscle enlarge, ocular motility limitation of glucocorticoid-refractory IOI. Treatment with TCZ appears to offer another therapeutic option in cases of recalcitrant or recurrent IOI in which conventional treatment fails or contraindications to intravenous glucocorticoid pulse therapy.
Detection of Abdominal Aortic Aneurysms via Bioelectrical Impedance Analysis – a pilot study
Authors: Hofmann Amun Georg , Shoumariyeh Tarik , Domenig Christoph , Skrabal Falko , Kovarik Johannes J. 
Published: February 2023

Abstract
Objective: To assess the feasibility of abdominal aortic aneurysm (AAA) detection based on parameters obtained from segmental bioimpedance measurements.
Design: Pilot study
Methods: In this single center exploratory pilot study, measurements were conducted in three different cohorts: patients with AAA, end stage renal disease patients without AAA, and healthy controls. The device used in the study, CombynECG, is an open market accessible device for segmental bioelectrical impedance analysis. The data was preprocessed and used to establish 4 different machine learning models on a randomized training sample. Each model was then evaluated on a test sample.
Results: The total sample included 22 patients with AAA, 16 chronic kidney disease patients, and 23 healthy controls. All four models showed strong predictive performance in the test partitions. Specificity ranged from 71.4 to 100 %, while sensitivity ranged from 66.7 to 100 %. The best performing model had 100% accuracy during classification on a test sample. Additionally, an exploratory analysis to approximate the maximum AAA diameter was conducted. An association analysis revealed potential variables that might hold predictive ability for aneurysm extent.
Conclusion: AAA detection via bioelectrical impedance analysis is technically feasible and appears to be a promising technology for large scale clinical studies as well as routine clinical screening assessment.
Oral-Health-Related Quality of Life in Adolescents: Umbrella Review
Authors: Chimbinha Italo Gustavo Martins , Ferreira Brenda Nayara Carlos , Miranda Giovana Pessoa , Guedes Renata Saraiva 
Published: February 2023

Abstract
Background: To evaluate oral conditions, demographic and socioeconomic characteristics of oral health-related quality of life in adolescents.
Methods: umbrella review, conducted according to the PRISMA checklist. The search strategy used a combination of words, applied in the electronic databases PubMed, WebScience, Embase, Lilacs, Scopus and Cochrane. Included publications until January 2022, without restrictions. Data collection took place with systematized practices and the eligibility criteria were studies focusing on quality of life related to oral health; teenagers; present the term “systematic review” and/or “meta-analysis” in the title or abstract. The quality assessment used the Assessment of Multiple Systematic Reviews (AMSTAR2) and the adherence of the article to the Preferred Reporting Items for Systematic Reviews and Meta Analyzes (PRISMA) was verified.
Results: 361 articles identified. 21 included. Systematic reviews focus on the English language, between 2009 and 2022 they showed heterogeneity in the methodological structuring process and were considered of low or critically low quality. Clinical conditions associated with worsening in quality of life were dental caries, malocclusion, dental trauma, toothache, edentulism, need for orthodontic treatment, irregular brushing and periodontal disease. Socioeconomic factors related to housing, parental education, access to health care, absence of siblings and nuclear family influence HRQoL. Completion of orthodontic treatment, health promotion programs, dental care and safe housing all have a positive impact.
Conclusion: Worse oral health status, older age, female sex and worse socioeconomic status were significantly associated with worse HRQoL.Registration :PROSPERO CRD4202129352
Oxalate nephropathy in an elderly patient with newly diagnosed celiac disease – a case report
Authors: Zijlstra Hendrik Wietse , Stegeman Coen A. 
Published: February 2023

Abstract
Oxalate nephropathy has widely been described in gastrointestinal disease,. This is only the second publication of oxalate nephropathy in newly diagnosed celiac disease. A 72-year-old Caucasian male presented to the hospital with abdominal discomfort and acute renal insufficiency with a creatinine of 290 µmol/L. The clinical course, laboratory results and urinalysis was suspect for tubular injury. Renal biopsy showed calcium oxalate depositions. Elevated serum and urine oxalate levels established the diagnosis oxalate nephropathy. The abdominal complaints, with steatorrhea and positive anti-tissue transglutaminase antibodies were diagnosed as celiac disease, which was confirmed after duodenal biopsies. Treatment with prednisone, gluten-free, low oxalate and normal calcium diet, lowered the serum oxalate levels and improved his renal function. Decreased absorption of free fatty acids can lead to increased free oxalate in the colon, due to the binding of free fatty acids to calcium, preventing the formation of the less absorbable calcium oxalate in the colon. Oxalate dispositions in the kidney can lead to acute tubular injury and chronic renal insufficiency. Celiac disease is therefore one of the intestinal diseases that can lead to hyperoxaluria and oxalate nephropathy.
Therapeutic effect of Ginsenoside Rb1 against mechanical trauma in a rat model of postpartum stress urinary incontinence
Authors: Chen Shaohui , Zhang Sanyuan , Wei Bingyan 
Published: February 2023

Abstract
Objective
The aim of the present study was to investigate the therapeutic effect of ginsenoside Rb1(GS-Rb1) on urethral mechanical trauma in a rat model of stress urinary incontinence (SUI) and the underlying mechanisms.
Design
24 female rats were divided into four groups: (1) control; (2) SUI; (3) SUI+ L-Rb1; (4) SUI+ H-Rb1 group. SUI models were induced via vaginal dilation (VD). Control rats received sham surgery.
Methods
The treatment rats received oral doses of ginsenoside Rb1 (4.5 mg/kg and 18 mg/kg, for the L and H groups, respectively) once per day for one week. Rats in the SUI group received the same volume of saline. On day 7, the leak point pressure (LPP) and maximum bladder capacity were evaluated and the rats were sacrificed. Urethral and vaginal wall tissue was examined using histology, immunohistochemistry, western blotting, and qPCR.
Results:
GS-Rb1 treatment was found to reduce urethral mechanical trauma, allowing periurethral tissue recovery. GS-Rb1 also reduced the numbers of fragmented and disorganized elastic and muscle fibers through activation of Nrf2/AREand TGF-β1/Smad3, leading to increased collagen synthesis and ameliorating damage to the urethral fibromuscular system.
Conclusion:
GS-Rb1 effectively reduced mechanical trauma to the urethral fibromuscular system in an SUI rat model. This was mediated by activation of Nrf2 antioxidant activity and TGF-β1/Smad3 signaling.
DNA methylation aberrancy is a reliable prognostic tool in uveal melanoma
Authors: Soltysova Andrea , Dvorska Dana , Kajabova Viera Horvathova , Pecimonova Martina , Cepcekova Klaudia , Ficek Andrej , Demkova Lucia , Buocikova Verona , Babal Pavel , Juras Ivan , Janikova Katarina , Kasubova Ivana , Samec Marek , Brany Dusan , Lyskova Darina , Dankova Zuzana , Smolkova Bozena , Furdova Alena 
Published: February 2023

Abstract
Background: Despite outstanding advances in understanding the genetic background of uveal melanoma (UM) development and prognosis, the role of DNA methylation reprogramming remains elusive. This study aims to clarify the extent of DNA methylation deregulation in the context of gene expression changes and its utility as a reliable prognostic biomarker.
Methods: Transcriptomic and DNA methylation landscapes in 25 high- and low-risk UMs were interrogated by Agilent SurePrint G3 Human Gene Expression 8×60K v2 Microarray and Human Infinium Methylation EPIC Bead Chip array, respectively. DNA methylation and gene expression of the nine top discriminatory genes, selected by the integrative analysis, were validated by pyrosequencing and qPCR in 58 tissues.
Results: Among 2,262 differentially expressed genes discovered in UM samples differing in metastatic risk, 60 were epigenetic regulators, mostly histone modifiers and chromatin remodelers. A total of 44,398 CpGs were differentially methylated, 27,810 hypomethylated, and 16,588 hypermethylated in high-risk tumors, with Δβ values ranging between -0.78 and 0.79. By integrative analysis, 944 differentially expressed DNA methylation-regulated genes were revealed, 635 hypomethylated/upregulated, and 309 hypermethylated/downregulated. Aberrant DNA methylation in high-risk tumors was associated with the deregulation of key oncogenic pathways such as EGFR tyrosine kinase inhibitor resistance, focal adhesion, proteoglycans in cancer, PI3K-Akt signaling, or ECM-receptor interaction. Notably, the DNA methylation values of nine genes, HTR2B, AHNAK2, CALHM2, SLC25A38, EDNRB, TLR1, RNF43, IL12RB2, and MEGF10, validated by pyrosequencing, demonstrated excellent risk group prediction accuracies (AUCs ranging between 0.870 and 0.956). Moreover, CALHM2 hypomethylation and MEGF10, TLR1 hypermethylation, as well as two three-gene methylation signatures, Signature 1 combining AHNAK2, CALHM2, and IL12RB and Signature 2 AHNAK2, CALHM2, and SLC25A38 genes, correlated with shorter overall survival (HR = 4.38, 95% CI 1.30-16.41, HR = 5.59, 95% CI 1.30-16.41; HR = 3.43, 95% CI 1.30-16.41, HR = 4.61, 95% CI 1.30-16.41 and HR = 4.95, 95% CI 1.39-17.58, respectively).
Conclusions: Our results demonstrate a significant role of DNA methylation aberrancy in UM progression. The advantages of DNA as a biological material and the excellent prediction accuracies of methylation markers open the perspective for their more extensive clinical use.
Smartphone-based surface plasmon resonance sensor for glyphosate detection: different pH and concentrations
Authors: Valle Anderson , Ferreira Kaline , Goulart Luiz , Freire Carmonizia , Medeiros Eliton , Filho Carlos Souza , Cruz Rossana , Rodrigues Luciano , Moreira Cleumar 
Published: February 2023

Abstract
Glyphosate [(N-phosphonomethyl) Glycine], one of the most worldwide commercialized herbicides, has provoked many debates about its carcinogenic effects. Here, a smartphone-based surface plasmon resonance (SPR) sensor is proposed for glyphosate detection using different pH and concentrations. CuO nanoparticles have been added to glyphosate samples, diluted in ultra-pure water solutions, to enhance its detection. An increase of sensitivity was observed in acidic solutions reaching a dilution of 10−8 (v/v), which is equivalent to 5·10−7 ppm. This novel smartphonebased SPR device for glyphosate detection besides presenting very high sensitivity, it has also favorable features such as easy handling, portability, and real-time analysis.
Correlation between long-term glycemic variability and cognitive function in middle-aged and elderly patients with type 2 diabetes mellitus
Authors: Ding Jingcheng , Shi Qian , Tao Qian , Su Hong , Du Yijun , Pan Tianrong , Zhong Xing 
Published: February 2023

Abstract
Objective
To investigate the correlation associated with long-term glycemic variability on cognitive function in middle-aged and elderly patients with T2DM.
Methods
This study was a single-institution, retrospective analysis of data. A total of 138 patients who were hospitalized in the Department of Endocrinology, the Second Affiliated Hospital of Anhui Medical University from June 2021 to November 2022 were recruited. The Montreal Cognitive Assessment (MoCA) was applied to assess the cognitive function of the patients, which were divided into MCI and non-MCI. Glycated hemoglobin A1c standard deviation (HbAlc-SD) and fasting plasma glucose standard deviation (FPG-SD) were used to measure long-term blood glucose fluctuations. General clinical data, blood biochemical indicators, and glycemic variability indicators were compared between the two groups of patients. The differences between the groups were compared using t-test, x2 test, ornonparametric test. Correlation and diagnostic power were further analyzed using multiple logistic regression analysis and ROC curve analysis.
Results
The differences in age, BMI, HbA1c-M, HbA1c-SD, FPG-M, FPG-SD, GFR, 24h urinary protein, and UACR were statistically significant between the two groups (P<0.05). In a multiple logistic regression analysis, HbA1c-SD and FPG-SD were found to be risk factors for cognitive dysfunction and eGFR to be a protective factor. The area under the curve (AUC) of HbA1c-SD for predicting MCI prevalence was 0.828 (95% CI 0.754～0.887, P<0.001), with a sensitivity of 62.69%, a specificity of 94.29%, and an optimal diagnostic value 1.01. The area under the curve (AUC) of FPG-SD for predicting MCI prevalence was 0.737 (95% CI 0.655～0.808, P<0.001), with a sensitivity of 76.12%, a specificity of 61.43%, and an best diagnostic value 0.94. The area under the curve (AUC) of eGFR for prediction of MCI prevalence was 0.712 (95% CI 0.628～0.786, P<0.01), with a sensitivity of 70.15 %, a specificity of 64.29 %, and an optimal diagnostic value 79.82 ml/min/1.73m2.
Conclusions
Long-term blood glucose variability affects cognitive function in middle-aged and elderly T2DM patients, and cognitive function is poorer in those with high blood glucose variability, for whom renal function is a protective factor.
Effect of Multiple Gestation delays in a Prey-Predator Food Chain System with Infected Class of Prey
Authors: Gupta Jyoti , dhar Joydip Dhar , Sinha Poonam 
Published: February 2023

Abstract
This article investigates a tri-trophic food chain model with the epidemic at the bottom level (prey) and gestation delays for the next two levels( the intermediate predator and top predator). The steady states' positivity, boundedness, existence, and stability have been analyzed. The study of Hopf bifurcation has been carried out for different steady states. It is shown that when the gestation delay for intermediate predator τ1 is absent, the interior equilibrium is locally stable for gestation delays of top predators τ2 ∈ (0,τ20+) and performs Hopf bifurcation for all τ2 >τ20+. Further, in the presence both the delay τ1 and τ2, the system becomes unstable when τ1, τ2 crosses their critical values τ10++}, τ20++ respectively and executes Hopf bifurcation τ1>τ10++, τ2>τ20++. Moreover, the proposed system is stable for τ1>τ10++, τ2<τ20++ and unstable for τ1<τ10++, τ2>τ20++. The sensitivity analysis of the system at coexistence steady state are presented to identify the effect of system parameters on the variables. Finally, we have presented a numerical simulation to verify our analytical findings.
Mathematics Subject Classification (2000) 34C23 · 34D20 · 92B05 · 92D30
Efficacy of photodynamic therapy in the treatment of actinic keratosis: a network meta-analysis
Authors: Wan Yuanyuan , Zeng Qinghai , Jiang Ling , Fu Chuhan , Mao Shunmin , Zhang Lan , Zhang Yushan , Zhang Xiaolin , Zhu Lu , Zhang Fan , Chen Jing , Lei Li 
Published: February 2023

Abstract
Background: Photodynamic therapy (PDT) is a highly effective treatment for actinic keratosis (AK), and uses different light sources as well as photosensitizers. In addition, PDT is often combined with other physical therapies or drugs. A network meta-analysis (NMA) allows for comparison between treatments not directly compared in randomized controlled trials (RCTs). This study’s objective was to compare the efficacy of different PDTs against AK lesions based on complete response rate (CR) by conducting a NMA.
Methods: The RCTs on the treatment of AK using PDT were screened, and a Bayesian model was developed using GeMTC 0.14.3 software to perform a NMA. The subgroups demarcated on the basis of the light sources and photosensitizers were also compared. RevMan 5.4.0 software was used to compare the outcome measure of different light sources in terms of relative risk ratio (RR) and a 95% confidence interval (CI). The therapeutic effects of different photosensitizers were compared using R 4.2.1 software and gemtc package version 1.0-1. The quality of the included literature was evaluated using the risk of bias assessment tool in RevMan 5.4.0, and the network plots between studies were drawn using STATA 16.0 software.
Results: Twenty-six trials involving 2285 patients and 14 treatments were included in the NMA. The results of the NMA showed that ablative fractional laser (AFL)-assisted methyl 5-aminolevulinic acid (MAL)-light-emitting diode (LED)-PDT had the best possible efficacy (Rank 1=0.56), followed by calcipotriol (CAL)-assisted MAL-LED-PDT (Rank 1=0.34) and 5-aminolaevulinic acid (ALA)-LED-PDT (Rank 1=0.05). The subgroup analysis showed that MAL-based PDT had better efficacy when using LED versus other light sources (RR：1.05，95% CI：1.03-1.07), and LED-based PDT resulted in the best possible efficacy when using ALA (Rank 1=0.47) versus other photosensitizers.
Conclusions: AFL combined with MAL-LED-PDT is most likely the best treatment option for AK. In case of monotherapies, PDT based on LED light source and ALA photosensitizer is a suitable choice.