bluuebunny/crossref_metadata_2025_split huggingface dataset:
The possibilities of intra-arterial chemioembolization in the treatment of patients with unresectable liver metastases of neuroendocrine tumors
Authors: Соловьева Людмила , Поликарпов Алексей , Попов Сергей , Павловский Александр , Козлов Алексей , Гранов Дмитрий , Майстренко Дмитрий 
Published: April 2023

Введение. Печень является основным органом метастазирования нейроэндокринных опухолей. Количество, размеры и распространение метастазов в печени считаются важными факторами, определяющими прогноз заболевания и качество жизни пациента. Относительно недавно резекция была единственным предпочтительным методом лечения. Однако, учитывая мультифокальный, преимущественно билобарный, характер поражения печени, пациенты с метастазами нейроэндокринных опухолей не подходят для оперативного вмешательства.
Цель. Анализ результатов применения внутриартериальной химиоэмболизации в лечении пациентов с нерезектабельными метастазами нейроэндокринных опухолей в печень.
Материалы и методы. Проведена ретроспективная оценка результатов лечения методами интервенционной радиологии 142 пациентов с метастатическим поражением печени при нейроэндокринных опухолях за период с 2006 по 2021 гг.
Результаты. После 2-х циклов регионарной химиотерапии полный ответ достигнут у 13 % пациентов, частичный — у 20 %, стабилизация — у 53 %, прогрессирование — у 14 %. Снижение проявлений карциноидного синдрома отмечено у 65 % пациентов. У пациентов с первично нерезектабельными метастазами нейроэндокринных опухолей в печень после регионарной химиотерапии удалось провести в 5 % случаев радикальные и в 8 % случаев циторедуктивные операции.
Заключение. Количество, размеры и расположение метастазов в печени считаются важными факторами, определяющими прогноз заболевания и качество жизни пациента. Учитывая мультифокальный, преимущественно билобарный, характер поражения печени, большинство пациентов с метастазами нейроэндокринных опухолей не подходят для оперативного вмешательства. Методы интервенционной радиологии являются эффективным альтернативным лечением, которое может уменьшить опухолевую нагрузку, облегчить симптоматическое проявление карциноидного синдрома, подготовить пациента к дальнейшему циторедуктивному вмешательству.
Modern possibilities of first-line therapy for advanced renal cell carcinoma: resolution based on the expert council's findings
Authors: Анжиганова Юлия , Бакланова Ольга , Варламов Сергей , Водолазский Владислав , Жаркова Ольга , Зуков Руслан , Иванова Феодосия , Копыльцов Евгений , Новикова Ольга , Скорая Марина , Усынин Евгений 
Published: April 2023

Представлены результаты заседания Регионального Совета экспертов Сибири и Дальнего Востока в нозологии почечно-клеточный рак, состоявшегося 20 мая 2022 г. в Новосибирске с целью согласования тактики ведения пациентов при системной терапии распространенного ПКР (рПКР), обсуждения клинического опыта применения комбинаций иммунотаргетных режимов, получения экспертного мнения относительно результатов исследования применения ленватиниба в комбинации с пембролизумабом у пациентов с рПКР. В задачах Совета было обсуждение различий подходов к лечению на основе клинических рекомендаций и реальной практики, возможностей обеспечения региональных пациентов современными опциями комбинированной терапии 1-й линии, специфики маршрутизации данной когорты больных. Повестка включала поиск портрета пациента, назначение которому комбинированной иммунотаргетной терапии ленватиниба с пембролизумабом окажет максимальный эффект с возможностью контроля токсичности. Одними из существенных оказались вопросы фармакоэкономики и пути их решения.
Differential Diagnosis of Metastatic Lesions in the Pancreas in Patients with Renal Cell Carcinoma and Focal Chronic Pancreatitis: A Clinical Observation
Authors: Перминова Алина , Коханенко Николай , Ханевич Михаил , Зиньковская Анна 
Published: April 2023

Представлено наблюдение 62-летней больной с метастатическим поражением поджелудочной железы почечно-клеточным раком спустя 15 лет после радикальной нефрэктомии справа. Заболевание успешно диагностировано безоперационным путем: выполнена тонкоигольная пункционная биопсия с последующим иммуногистохимическим исследованием препарата, таким образом диагноз был верифицирован и исключен очаговый хронический панкреатит. Пациентке проведена лекарственная противоопухолевая терапия, которую она перенесла хорошо, достигнут частичный ответ.

Ключевые слова: почечноклеточный рак, почечноклеточная карцинома, очаговый панкреатит, карцинома поджелудочной железы, псевдокиста головки поджелудочной железы, иммуногистохимическое исследование.
Авторы подтверждают отсутствие конфликтов интересов.
El Programa Nacional de Trasplante de componentes anatómicos de Panamá, un ejemplo del sistema integrado de salud: MINSA-Caja de Seguro Social
Authors: Vernaza Alejandro 
Published: April 2023

El primer trasplante de riñón fue efectuado en 1990 a un paciente asegurado con donante vivo. En el año 2006, el Ministerio de Salud y la Caja de Seguro Social firman el Convenio DAL 002-2006 para extender la prestación de servicios de salud destinados a los programas de trasplante renal, células hematopoyéticas, hígado y corazón para donantes y receptores asegurados y no asegurados.
Este Convenio estableció el Programa de trasplante como un proceso ordenado de actividades que benefició a todos los panameños que esperaban un trasplante de donante vivo o fallecido y dio inicio al innovador y exitoso Sistema Integrado de Salud en Trasplante.
Previo a este convenio se había creado el Comité Nacional de Trasplante como colegio multidisciplinario que incluyó a representantes de todos los profesionales médicos, técnicos y enfermeras , necesarios para evaluar los protocolos clínicos e inmunológicos pre trasplante de receptor y donante según el tipo de trasplante y autorizar el trasplante, y la Organización Panameña de Trasplante (OPT) como organismo técnico operativo que siguiendo los principios de cooperación, eficiencia, equidad , calidad y solidaridad, con la finalidad de trabajar con el Sistema de Salud panameño a fin de coordinar las actividades de promoción, donación, extracción, preservación, distribución e intercambio y trasplante de componentes anatómicos.
ETNOMATEMATIKA YANG TERDAPAT PADA TARIAN GAWE AU MASYARAKAT ADONARA
Authors: Helan Gratia Celsiana Gita , Resi Bernadus Bin Frans , Wolo Hironimus Bao 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui konsep-konsep matematika yang terdapat pada tarian gawe au. Penelitian ini dilaksanakan pada bulan Oktober-Desember 2022. Jenis penelitian yang digunakan yakni penelitian deskriptif kualitatif. Subjek dalam penelitian ini adalah 1 orang tua adat dan 10 orang penari gawe au. Objek penelitian ini adalah semua aspek dan aktivitas matematika yang terdapat dalam tarian gawe au. Untuk memperoleh data, peneliti menggunakan teknik observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan reduksi data, penyajian data dan penarikan kesimpulan. Berdasarkan data hasil penelitian dan pembahasan dapat disimpulkan bahwa tarian gawe au memiliki konsep-konsep matematika yakni: geometri sudut, geometri dimensi dua dan geometri garis.
Study of attitude and behaviour of healthcare professionals towards the patients in an Emergency Department during the COVID-19 pandemic
Authors: VAISHNAV NITESH , KUMAR BHARAT , MISRA ARUP KUMAR , GARG M. K. 
Published: April 2023

Background:
COVID-19 outbreak is known to have a psychological impact on patients.

Background and Objective:
The main aim of the study was a to study the attitude and behavior of health care professionals (HCPs) in the emergency department towards chronic patients during COVID-19 pandemic and also the accessibility of healthcare system during COVID-19 period and to compare it with the pre-COVID period.

Materials and Methods:
A random sampling technique was used, and a pre-designed questionnaire named the Brief Emergency Department Patients' Satisfaction Scale was adopted to record the patient's satisfaction with the healthcare services.

Results:
The patients admitted to the emergency ward felt that the nursing and physicians' care in the emergency department was highly satisfactory in the pre-COVID period. In the COVID period, the same set of patients who got admitted felt that there was a deterioration in the behaviour and attitude of the HCPs towards them. In the COVID period, 30% of the patients felt that there was a marked deterioration in the general services in the emergency department. It was also observed in the study, that there was a marked change in the attitude and behaviour of the HCPs in the emergency department at the time of the COVID pandemic.

Conclusion:
COVID-19 has significantly changed the attitude and behaviour of HCPs. The disease has critically transformed the working environment and the approach of HCPs to treat the patients. It is imperative to employ productive strategies to care for the health of our HCP.
Evolving epidemiology and chemical analysis of urinary stones
Authors: SINGLA PARUL , MANOCHA ANJALI , BHARGAVA SEEMA , KANKRA MAMTA , SHARMA ANISHA 
Published: April 2023

Background:
Renal stones are a painful urological disorder resulting from the combined influence of epidemiological, biochemical and genetic risk factors. A high recurrence risk has been reported for renal stones, and 0.6%–3.2% cases may progress to end stage renal disease. Modern lifestyle, sedentary habits and unhealthy dietary practices are primary promoters of the stone boom in this millennium.

Aims and Objectives:
The aim of the present study is to evaluate the percentage of the stone type according to chemical composition and their association with epidemiological factors like sex and age. A retrospective analysis of the chemical composition of the stone samples received was done.

Material and Methods:
Stones samples were processed by Stone Analysis Set (BIOLABO S A, France). Qualitative chemical analysis was done for calcium, phosphorus, ammonium ion, oxalate, cystine, magnesium, carbonate and uric acid.

Results:
Type of renal stone and its incidence with age and sex have been evaluated. The total number of patients reporting to the hospital with renal stones was 123. Of these, 69.11% were male and 30.89% were female, with a male to female ratio of 2.23:1. The maximum occurrence was in the third and fourth decade of life. On analysis, 72.35% of total stones comprised calcium oxalate and 23.57% of nonoxalate (phosphate, magnesium, carbonate, ammonium ion) stones, whereas uric acid was positive in 4.06%.

Conclusion:
The occurrence of renal stones according to epidemiological factors such as age and sex in our study are similar to those reported in studies from developed countries. The data on urinary stones indicate that 98% were located in the upper urinary tract. Oxalate stones represent the main form of urolithiasis, affecting males more than females. The most important cause studied for renal stone formation is metabolic disturbances, but the genetic factors associated with the occurrence and recurrence of stone and mineral homeostasis of ions in kidney of stone formers should be further evaluated.
Risk factors and outcomes for carbapenem-resistant klebsiella pneumoniae in hematological patients
Authors: KAHRAMAN Selda , TEREK ECE Gülfem , CAGİRGAN Seçkin 
Published: April 2023

Background Prolonged hospitalization, prolonged neutropenia, and immunosuppressive treatments increase bloodstream infections in hematological patients. Identifying risk factors for carbapenem-resistant Klebsiella pneumonia (CRKP) infection will shed light on controlling the spread of CRKP. Our retrospective study aimed to determine the clinical features, antimicrobial susceptibility, and mortality risk factors of patients who developed CRKP in patients followed up for hematological cancer in the Izmir University of Economics Haematology Department.
Material and Methods 19,170 blood-urine-sputum cultures were delivered from the patients, 1,595 (8.31%) of which presented growth. CRKP comprised 302 (1.57%) of such growth cases. The study included 72 patients with hematological malignancy who presented CRKP growth in 302 cultures obtained during the neutropenic fever period.
Results The mean age of patients was 51 (18-75 years). Acute myeloid leukemia was the most common disease (n: 26, 36.11%). As to the antibiotic sensitivity of CRKP, 44 patients (61.1%) were colistin sensitive, 28 patients (38.9%) were colistin-resistant, 47 patients (65.3%) were tigecycline sensitive/medium sensitivity, 25 patients (34.7%) were tigecycline resistant, there was no statistically significant difference between antibiotic sensitivities and survival.
Conclusions Today, early detection of CRKP colonization in high-risk hematological patients, taking rectal culture, and if the patient presents rectal colonization of CRKP or had CRKP bacteremia during prior hospitalizations, early initiation of treatment with antibiotics acting against CRKP during NPF would significantly reduce mortality.
Renal Involvement and Outcomes in Patients Hospitalized with COVID-19 Infection in A Tertiary Hospital
Authors: K.S. Sahana , BH PAİ Santhosh , GEORGE Rony 
Published: April 2023

Background Kidney involvement is seen frequently in COVID-19 patients and is essential to the prognosis. This study is undertaken to describe the clinical presentation of renal involvement in COVID-19 patients concerning acute kidney injury (AKI), chronic kidney disease (CKD), and urinary abnormalities and to correlate with the severity of COVID-19 illness and its outcome.
Material and Methods A retrospective cross-sectional study reviewed the medical records of patients admitted with COVID-19 infection who had pre-existing renal conditions or renal manifestations in the form of deranged renal function tests or abnormal urinary findings. All the relevant clinical and laboratory parameters, including the treatment details and outcome, were noted, and statistical analysis was done.
Results A total of 72 out of 1,544 patients satisfied the inclusion criteria. Hypertension (72%) and Diabetes (62%) were the commonest co-morbidities noted. CKD was seen in 51 (70%) patients, and 21 patients (29%) were on maintenance dialysis. 39 (76%) patients with CKD were diagnosed with severe COVID-19, 25 (49%) of the patients developed acute worsening of CKD, and 45% had mortality. AKI was seen in 19 patients (26%). Urinary abnormality was seen in 34 (47%) patients, out of which 27 (37%) had proteinuria of more than 1+. Haematuria was seen in 27 (37.5%) patients, of which 12(17%) had gross haematuria. Dialysis was required in 24 patients (33%) additionally. Mechanical ventilation was required in 32(44%) patients, and inotropes in 41(56%). 21 (29%) patients developed acute respiratory distress syndrome, 39 (54%) had sepsis, with six patients developing multiorgan dysfunction syndrome. 62.5% of patients had mortality. The presence of other comorbid conditions, thrombocytopenia, coagulopathy, abnormality in arterial blood gases, and usage of inotropes were found to be significantly associated with adverse outcomes.
Conclusions Most cases had severe renal system involvement, with an AKI prevalence rate of 1.2% and a case-specific mortality rate of 62.5%.
What is the main reason of erectile dysfunction in lymphoma patients: Chemotherapy or Depression?
Authors: YALÇIN Cumali , ERDOĞAN Aslan , YILMAZ Güven 
Published: April 2023

Background Erectile dysfunction (ED) may be associated with chemotherapy and depression in lymphoma patients. The role of depression in developing ED in lymphoma patients may be more critical than chemotherapy. This study aimed to determine which plays a more important role in ED.
Material and Methods This study included 20 patients aged under 60 years who were admitted to the Hematology Outpatient Clinic between March 2015 and March 2016 and diagnosed with lymphoma. While the Beck Depression Inventory (BDI) was used to assess depression severity before (T1), during (T2) and after (T3) chemotherapy, the International Index of Erectile Function (IIEF) was used to assess sexual function. The Mann-Whitney U and Wilcoxon signed-rank tests were used for statistical analysis. A p-value of
Use of dapsone in chronic/refractory immune thrombocytopenic patients: A single center experience
Authors: CANDAR Ömer , OZKOCAMAN Vildan , ERSAL Tuba , ZOR TURNA Tuğçe , PINAR İbrahim Ethem , YALÇIN Cumali , ORHAN Bedrettin , ÇUBUKÇU Sinem , GÜLLÜ KOCA Tuba , ALİ Rıdvan , ÖZKALEMKAŞ Fahir 
Published: April 2023

Background: Dapsone is a second-line therapy for immune thrombocytopenia (ITP). It is cost-effective, with a response rate comparable to other drugs used as second-line therapy, such as azathioprine, danazol, cyclophosphamide, cyclosporine, vincristine, rituximab, and eltrombopag.
Material and Methods: This retrospective study analyzed ten adult patients who presented to our hematology division outpatient clinic between March 2013 and July 2021, was diagnosed with chronic/refractory ITP, did not respond to first-line therapy, and used dapsone.
Results: Eight (80%) patients were female, and 2 (20%) were male. The median age was 50 (range, 24-64) years. The mean pre-treatment platelet value was 12.8x109/L (range: 4-22.1x109/L). The median duration of symptoms before dapsone treatment was 60 (6-360) months. The median number of treatments received before dapsone was 4 (range: 3-6). All patients were routinely treated with oral dapsone 50 mg for two weeks, followed by 100 mg. The median time to treatment response was 39 (range: 14-90) days. The response rate was 60% (complete response 40%, partial response 20%). Asymptomatic anemia was observed as a side effect in only one patient.
Conclusions: Based on these results, it can be speculated that dapsone is an effective, inexpensive, and well tolerated
treatment option. Considering the economic status of developing countries, it seems very attractive
to use dapsone as the second-line therapy for chronic/refractory ITP. To the best of our knowledge, this is the
first study in Turkey on the use of dapsone for chronic/refractory ITP.
Correlation between Chest Radiograph and Lung Ultrasound with Clinical Appearance in Hyaline Membrane Disease Patients
Authors: Zerbarani Wa Ode , Asriani Sri , Muis Mirna , Alasir Ema 
Published: April 2023

ABSTRACT Background: Hyaline membrane disease (HMD) is a respiratory distress disease in premature infants due to surfactant deficiency. The combination of clinical, laboratory and radiological features makes it easy to quickly, precisely & accurately establish HMD which is important for early therapy in preventing death. Purpose: Knowing the suitability between chest X-ray & Thorax ultrasound with the clinical picture in HMD patients. Methods: This study is an observational study with a cross sectional method conducted in the radiology & NICU section of Dr. Wahidin Sudirohusodo Makassar from August 2021 to January 2022. Sampling was done by consecutive sampling. The researcher performed a thorax ultrasound & assessed the chest x-ray. The results were verified by two pediatric radiology consultants. Results: The largest sample was in neonates at 34 weeks of gestation, 8 samples (21.1%), sex with 25 samples (65.8%), the highest birth weight between 1000-2000 grams 32 samples (84.2%) , the most preterm etiology was due to severe preeclampsia in 13 samples (34.2%), the most deliveries were by cesarean section 34 samples (89.4%), the highest APGAR Score was in moderate degree 25 samples (65.8%), the highest O2 saturation was between 90 -94%, namely 24 samples (63.2%), the most down scores were moderate degrees 15 samples (39.5%), HMD degrees based on chest radiographs were mostly grade II 25 samples (65.8%), HMD degrees based on thorax ultrasound the most in the moderate degree 19 samples (50%).Conclusion: Ultrasound is considered as the radiological modality of choice because it is safe, inexpensive, easy & sensitive to assess respiratory distress in neonates but is influenced by the operator's ability to apply it.Keywords: hyaline membrane disease, down score, chest radiograph, lung ultrasound
Evaluasi Pengelolaan Obat di Instalasi Farmasi Rumah Sakit Angkatan Darat dr. R. Ismoyo Kendari Tahun 2018
Authors: Sabarudin Sabarudin , Ihsan Sunandar , Nirmala Fifi , Tendri Adjeng Andi Nafisah , Dzulhijjah Dzulhijjah 
Published: April 2023

ABSTRAKLatar Belakang: Pengelolaan obat merupakan salah satu segi manajemen rumah sakit yang sangat penting dalam penyediaan pelayanan kesehatan secara paripurna. Ketidakefisienan dalam pengelolaan obat akan memberi dampak negatif bagi rumah sakit, baik secara medik, sosial maupun secara ekonomi. Tujuan: Penelitian ini bertujuan untuk melakukan evaluasi pengelolaan obat di Instalasi Farmasi Rumah Sakit Angkatan Darat dr. R. Ismoyo Kendari Tahun 2018 yang meliputi tahap seleksi, perencanaan, pengadaan, penyimpanan, distribusi dan penggunaan. Metode: Penelitian ini merupakan penelitian deskriptif non eksperimental dengan pengambilan data secara retrospektif dan concurent menggunakan metode randomized sampling. Instrumen yang digunakan adalah lembar observasi dan panduan wawancara. Lembar observasi digunakan untuk mendokumentasikan data yang diperoleh terkait data pengelolaan obat sedangkan panduan wawancara digunakan untuk mendukung data observasi yang diperoleh melalui lembar observasi. Hasil: Hasil penelitian menunjukan bahwa kesesuaian item obat yang tersedia dengan DOEN sebesar 59,06%, presentase jumlah item obat yang direncanakan dan yang diadakan sebesar 100%, presentase kesalahan faktur sebesar 3,22%, frekuensi tertundanya pembayaran faktur 0%, ketepatan data jumlah obat pada kartu stok 100%, presentase stok mati sebesar 1,64%, nilai Turn Over Ratio (TOR) adalah 4,85 kali, presentase peresepan dengan nama generik sebesar 90,5% dan presentase peresepan antibiotik sebesar 20,83%. Simpulan: Pengelolaan obat di Instalasi Farmasi Rumah Sakit Angkatan Darat dr. R. Ismoyo Kendari Tahun 2018 pada tahap perencanaan dan tahap penggunaan sudah efisien, sedangkan tahap seleksi, pengadaan, penyimpanan dan tahap distribusi belum efisien.Kata Kunci: Pengelolaan Obat, Instalasi Farmasi, RSAD dr. R. Ismoyo
Perbandingan Skor Insersi LMA antara Pemberian Petidin-propofol dan Fentanil-propofol Intravena
Authors: Ali Agussalim , Gaus Syafruddin , Ahmad Muhammad Ramli 
Published: April 2023

ABSTRAKLatar Belakang Pemberian adjuvan seperti opioid, lidokain, midazolam dan pelumpuh otot dosis kecil bersama propofol mampu meningkatkan keberhasilan insersi LMA. Petidin adalah opioid yang memiliki aktivitas seperti anestetik lokal dengan harga relatif murah dibanding opioid lain. Tujuan penelitian Membandingkan skor insersi LMA antara antara pemberian petidin-propofol intravena dengan fentanil-propofol intravena.Metode Lima puluh empat pasien ASA PS 1 dan 2 dengan rentang umur 17-60 tahun, BMI 18,5-30 kg/m2 dan mallampati I-II yang direncanakan operasi elektif dengan prosedur GA-LMA diacak kedalam 2 grup dengan menggunakan desain acak tersamar ganda. Grup P mendapatkan petidin 1 mg/kgBB 10 menit sebelum induksi dan grup F mendapatkan fentanil 1 µg/kgBB 3 menit sebelum induksi. Induksi menggunakan propofol 2 mg/kgBB selama 60 detik. Ventilasi dengan oksigen 100% melalui sungkup muka selama 60 detik dilakukan setelah refleks bulu mata hilang, selanjutnya dilakukan insersi LMA dan penilaian skor insersi LMA berdasarkan Lund & Stovener (gerakan anggota tubuh, laringospasme, menelan, batuk dan tersedak).Hasil Skor insersi LMA sangat memuaskan pada kelompok P lebih kecil dibandingkan kelompok F (29,6% vs 48,1%), namun tidak bermakna setelah uji statistik Chi-Square (p=0,264).Simpulan Skor insersi LMA dengan pemberian petidin-propofol intravena samabaiknya dengan pemberian fentanil-propofol intravena.Kata kunci :laryngeal mask airway, fentanyl, petidin, , propofol,