bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrhythmogenic substrate elimination for safe testosterone therapy in symptomatic Brugada syndrome patients
Authors: Negro Gabriele , Boccellino Antonio , Napolano Antonio , Micaglio Emanuele , Calovic Zarko , Anastasia Luigi , Ciconte Giuseppe 
Published: August 2023

Abstract

Background
Brugada Syndrome (BrS) is a cardiogenetic disease known for its association with sudden cardiac death (SCD) in individuals with structurally normal hearts. The prevalence of BrS is higher in males, who also face a greater risk of SCD. Its higher prevalence and worse outcome in male subjects may be due to testosterone effects on ion channels expression and function. The influence of testosterone on cardiac action potentials, both genomically and non-genomically, underscores its potential role in unmasking the syndrome and triggering life-threatening arrhythmias. Notably, testosterone replacement therapy (TRT), used for hypogonadism and gender reassignment, has been linked to BrS unmasking. The role of epicardial ablation in symptomatic BrS patients where hormonal therapy cannot be discontinued is unknown.

Methods and results
In this study we describe the first two cases of substrate mapping and ablation in BrS patients experiencing arrhythmic events while on TRT. In both cases, high-density epicardial mapping revealed abnormal areas of prolonged and fragmented electrograms in the right ventricular (RV) outflow tract and anterior wall. These abnormalities were completely abolished by radiofrequency ablation (RFA). After ablation, both patients showed a persistent normalization of the ECG and were free from ventricular arrhythmias at follow-up, despite ongoing TRT.

Conclusion
RFA can be considered as a therapeutic option in symptomatic BrS patients with a high-risk profile who cannot discontinue TRT, being essential for restoring their normal physiology or preserving their sexual identity. As testosterone use is increasing, further studies are warranted to define a standardized diagnostic and therapeutic strategy in this specific subset of BrS patients.
COPI coatomer subunit α-COP interacts with the RNA binding protein Nucleolin via a C-terminal dilysine motif
Authors: Custer Sara K , Gilson Timra , Astroski Jacob W , Nanguneri Siddarth R , Iurillo Alyssa M , Androphy Elliot J 
Published: August 2023

Abstract
The COPI coatomer subunit α-COP has been shown to co-precipitate mRNA in multiple settings, but it was unclear whether the interaction with mRNA was direct or mediated by interaction with an adapter protein. The COPI complex often interacts with proteins via C-terminal dilysine domains. A search for candidate RNA binding proteins with C-terminal dilysine motifs yielded Nucleolin, which terminates in a KKxKxx sequence. This protein was an especially intriguing candidate as it has been identified as an interacting partner for Survival Motor Neuron protein (SMN). Loss of SMN causes the neurodegenerative disease Spinal Muscular Atrophy. We have previously shown that SMN and α-COP interact and co-migrate in axons, and that overexpression of α-COP reduced phenotypic severity in cell culture and animal models of SMA. We show here that in an mRNA independent manner, endogenous Nucleolin co-precipitates endogenous α-COP and ε-COP but not β-COP which may reflect an interaction with the so-called B-subcomplex rather a complete COPI heptamer. The ability of Nucleolin to bind to α-COP requires the presence of the C-terminal KKxKxx domain of Nucleolin. Furthermore, we have generated a point mutant in the WD40 domain of α-COP which eliminates its ability to co-precipitate Nucleolin but does not interfere with precipitation of partners mediated by non-KKxKxx motifs such as the kainate receptor subunit 2. We propose that via interaction between the C-terminal dilysine motif of Nucleolin and the WD40 domain of α-COP, Nucleolin acts an adaptor to allow α-COP to interact with a population of mRNA.
Discrete Gagliardo–Nirenberg inequality and application to the finite volume approximation of a convection–diffusion equation with a Joule effect term
Authors: Calgaro Caterina , Cancès Clément , Creusé Emmanuel 
Published: August 2023

Abstract
A discrete order-two Gagliardo–Nirenberg inequality is established for piecewise constant functions defined on a two-dimensional structured mesh composed of rectangular cells. As in the continuous framework, this discrete Gagliardo–Nirenberg inequality allows to control in particular the $L^4$ norm of the discrete gradient of the numerical solution by the $L^2$ norm of its discrete Hessian times its $L^\infty $ norm. This result is crucial for the convergence analysis of a finite volume method for the approximation of a convection–diffusion equation involving a Joule effect term on a uniform mesh in each direction. The convergence proof relies on compactness arguments and on a priori estimates under a smallness assumption on the data, which is essential also in the continuous framework.
Outcome of a conservatively treated large Pipkin I fracture dislocation: a case report
Authors: Alfreihi Omar , Alrashedan Bander S , Aljohani Hamid T , Alturaisi Sarah O , Mahmoud Jameel , Serhan Hani S 
Published: August 2023

Abstract
Pipkin I fracture dislocation is a rare injury. They commonly present following high mechanism trauma with possible devastating complications regardless of the treatment option. Treatment consensus depends on fracture reduction, size, site, and displacement. Surgical management is reserved for large fragments. We present a 42-year-old female presented with multiple chest injuries and left sided Pipkin I fracture dislocation Two days following the trauma. The fracture was found to be vertical in nature and was managed by closed reduction and a period of bed rest and skeletal traction. She was followed over a 3-year period and showed satisfactory results. We believe that the vertical nature of the fracture and maintenance of the anatomic reduction led to her successful outcome.
Proxy Survey Cost Indicators in Interviewer-Administered Surveys: Are they Actually Correlated with Costs?
Authors: Wagner James , Centeno Lena , Dulaney Richard , Edwards Brad , Suzer-Gurtekin Z Tuba , Coffey Stephanie 
Published: August 2023

Abstract
Survey design decisions are—by their very nature—tradeoffs between costs and errors. However, measuring costs is often difficult. Furthermore, surveys are growing more complex. Many surveys require that cost information be available to make decisions during data collection. These complexities create new challenges for monitoring and understanding survey costs. Often, survey cost information lags behind reporting of paradata. Furthermore, in some situations, the measurement of costs at the case level is difficult. Given the time lag in reporting cost information and the difficulty of assigning costs directly to cases, survey designers and managers have frequently turned to proxy indicators for cost. These proxy measures are often based upon level-of-effort paradata. An example of such a proxy cost indicator is the number of attempts per interview. Unfortunately, little is known about how accurately these proxy indicators actually mirror the true costs of the survey. In this article, we examine a set of these proxy indicators across several surveys with different designs, including different modes of interview. We examine the strength of correlation between these indicators and two different measures of costs—the total project cost and total interviewer hours. This article provides some initial evidence about the quality of these proxies as surrogates for the true costs using data from several different surveys with interviewer-administered modes (telephone, face to face) across three organizations (University of Michigan’s Survey Research Center, Westat, US Census Bureau). We find that some indicators (total attempts, total contacts, total completes, sample size) are correlated (average correlation ∼0.60) with total costs across several surveys. These same indicators are strongly correlated (average correlation ∼0.82) with total interviewer hours. For survey components, three indicators (total attempts, sample size, and total miles) are strongly correlated with both total costs (average correlation ∼0.77) and with total interviewer hours (average correlation ∼0.86).
Comparative morphoanatomy and transcriptomic analyses reveal key factors controlling floral trichome development in Aristolochia (Aristolochiaceae)
Authors: Suárez-Baron Harold , Alzate Juan F , Ambrose Barbara A , Pelaz Soraya , González Favio , Pabón-Mora Natalia 
Published: August 2023

Abstract
Trichomes are specialized epidermal cells in aerial plant parts. Trichome development proceeds in three stages, determination of cell fate, specification, and morphogenesis. Most genes responsible for these processes have been identified in the unicellular branched leaf trichomes from the model Arabidopsis thaliana. Less is known about the molecular basis of multicellular trichome formation across flowering plants, especially those formed in floral organs of early diverging angiosperms. Here, we aim to identify the genetic regulatory network (GRN) underlying multicellular trichome development in the kettle-shaped trap flowers of Aristolochia (Aristolochiaceae). We selected two taxa for comparison, A. fimbriata, with trichomes inside the perianth, which play critical roles in pollination, and A. macrophylla, lacking specialized trichomes in the perianth. A detailed morphoanatomical characterization of floral epidermis is presented for the two species. We compared transcriptomic profiling at two different developmental stages in the different perianth portions (limb, tube, and utricle) of the two species. Moreover, we present a comprehensive expression map for positive regulators and repressors of trichome development, as well as cell cycle regulators. Our data point to extensive modifications in gene composition, expression, and putative roles in all functional categories when compared with model species. We also record novel differentially expressed genes (DEGs) linked to epidermis patterning and trichome development. We thus propose the first hypothetical genetic regulatory network (GRN) underlying floral multicellular trichome development in Aristolochia, and pinpoint key factors responsible for the presence and specialization of floral trichomes in phylogenetically distant species of the genus.
Prehospital Lessons From the War in Ukraine: Damage Control Resuscitation and Surgery Experiences From Point of Injury to Role 2
Authors: Quinn John , Panasenko Serhii I , Leshchenko Yaroslav , Gumeniuk Konstantyn , Onderková Anna , Stewart David , Gimpelson A J , Buriachyk Mykola , Martinez Manuel , Parnell Tracey A , Brain Leonid , Sciulli Luke , Holcomb John B 
Published: August 2023

ABSTRACT
The ongoing war in Ukraine presents unique challenges to prehospital medical care for wounded combatants and civilians. The purpose of this article is to identify, describe, and address gaps in prehospital care, casualty evacuation, and medical evacuation throughout Ukraine to share lessons for other providers. Observations and experiences of medical personnel were collected and analyzed, focusing on pain management, antibiotic use, patient assessment, mass casualty triage, blood loss, hypothermia, transport immobilization, and clinical governance. Gaps identified include limited access to pain management, lack of antibiotic guidance, inadequate patient assessment and triage, access to damage control resuscitation and blood, challenged transport immobilization practices, and challenges with clinical governance for both local and foreign providers. Improved prehospital care and casualty and medical evacuation in Ukraine are required, through increased use of empiric pain management, focused antibiotic guidance, enhanced patient assessment and triage in the form of training, access to prehospital blood, and better transport immobilization practices. A robust and active lessons learned program, trauma data capture, and quality improvement process is needed to reduce preventable morbidity and mortality in the war zone. The recommendations presented in this article serve as a starting point for improvements in prehospital care in Ukraine with potential to change prehospital training for the NATO alliance and other organizations operating in similar areas of conflict.
Graphical Abstract
Perineural Injection Therapy for Chronic Exertional Compartment Syndrome Refractory to Initial Compartment Release: A Case Report
Authors: Bui Tam , Anies Lt Ervin , Super Eric , Jahja Erol , Janze Aeneas 
Published: August 2023

ABSTRACT
This is a case of a 26-year-old active duty male with a 1-year history of distal anterolateral leg pain and numbness which would persist following activity cessation. He was referred to physical therapy and eventually orthopedic surgery for bilateral anterior exertional compartment syndrome and underwent bilateral anterolateral fasciotomies. One year after surgery, he continued to have pain along the posterior aspect of his lower legs with residual numbness over his left dorsomedial foot. He was referred to sports medicine for further evaluation and Botox injections without significant symptomatic changes. He subsequently underwent diagnostic ultrasound of his lower legs which showed multiple entrapment points of the left superficial peroneal nerve along the fasciotomy scar. An additional electrodiagnostic study showed left superficial peroneal sensory mononeuropathy. Eighteen months following surgery, he received his first perineural injection therapy (PIT) treatment. A mixture of lidocaine and D5W was prepared to achieve 1 mg/cc which was then injected along his tibial, saphenous, and sural nerves. Following four PIT sessions, the patient’s overall lower extremity pain, weakness, and functionality had improved. This case demonstrates potential benefit with PIT in patients with refractory symptoms following surgery for chronic exertional compartment syndrome. These symptoms may be due to chronic irritation of cutaneous nerves and they may benefit from treatment with PIT. Our case may represent a possible paradigm shift in the conservative treatment of chronic exertional compartment syndrome, especially when refractory to surgical compartment release.
The X-ray polarization of the Seyfert 1 galaxy IC 4329A
Authors: Ingram A , Ewing M , Marinucci A , Tagliacozzo D , Rosario D J , Veledina A , Kim D E , Marin F , Bianchi S , Poutanen J , Matt G , Marshall H L , Ursini F , De Rosa A , Petrucci P-O , Madejski G , Barnouin T , Gesu L Di , Dovčiak M , Gianolli V E , Krawczynski H , Loktev V , Middei R , Podgorny J , Puccetti S , Ratheesh A , Soffitta P , Tombesi F , Ehlert S R , Massaro F , Agudo I , Antonelli L A , Bachetti M , Baldini L , Baumgartner W H , Bellazzini R , Bongiorno S D , Bonino R , Brez A , Bucciantini N , Capitanio F , Castellano S , Cavazzuti E , Chen C-T , Ciprini S , Costa E , Del Monte E , Lalla N Di , Marco A Di , Donnarumma I , Doroshenko V , Enoto T , Evangelista Y , Fabiani S , Ferrazzoli R , García J A , Gunji S , Heyl J , Iwakiri W , Jorstad S G , Kaaret P , Karas V , Kislat F , Kitaguchi T , Kolodziejczak J J , Monaca F La , Latronico L , Liodakis I , Maldera S , Manfreda A , Marscher A P , Mitsuishi I , Mizuno T , Muleri F , Negro M , Ng C-Y , O’Dell S L , Omodei N , Oppedisano C , Papitto A , Pavlov G G , Peirson A L , Perri M , Pesce-Rollins M , Pilia M , Possenti A , Ramsey B D , Rankin J , Roberts O J , Romani R W , Sgrò C , Slane P , Spandre G , Swartz D A , Tamagawa T , Tavecchio F , Taverna R , Tawara Y , Tennant A F , Thomas N E , Trois A , Tsygankov S S , Turolla R , Vink J , Weisskopf M C , Wu K , Xie F , Zane S 
Published: August 2023

ABSTRACT
We present an X-ray spectro-polarimetric analysis of the bright Seyfert galaxy IC 4329A. The Imaging X-ray Polarimetry Explorer (IXPE) observed the source for ∼500 ks, supported by XMM–Newton (∼60 ks) and NuSTAR (∼80 ks) exposures. We detect polarization in the 2–8 keV band with 2.97σ confidence. We report a polarization degree of 3.3 ± 1.1 per cent and a polarization angle of 78° ± 10° (errors are 1σ confidence). The X-ray polarization is consistent with being aligned with the radio jet, albeit partially due to large uncertainties on the radio position angle. We jointly fit the spectra from the three observatories to constrain the presence of a relativistic reflection component. From this, we obtain constraints on the inclination angle to the inner disc (&lt;39° at 99 per cent confidence) and the disc inner radius (&lt;11 gravitational radii at 99 per cent confidence), although we note that modelling systematics in practice add to the quoted statistical error. Our spectropolarimetric modelling indicates that the 2–8 keV polarization is consistent with being dominated by emission directly observed from the X-ray corona, but the polarization of the reflection component is completely unconstrained. Our constraints on viewer inclination and polarization degree tentatively favour more asymmetric, possibly out-flowing, coronal geometries that produce more highly polarized emission, but the coronal geometry is unconstrained at the 3σ level.
Probing the impact of WIMP dark matter on universal relations, GW170817 posterior, and radial oscillations
Authors: Routaray Pinku , Quddus Abdul , Chakravarti Kabir , Kumar Bharat 
Published: August 2023

ABSTRACT
In this study, we investigate the impact of weakly interacting massive particles (WIMPs) dark matter (DM) on C–Λ universal relations, GW170817 posterior, and radial oscillations of neutron stars (NSs) by considering the interactions of uniformly trapped neutralinos as a DM candidate with the hadronic matter through the exchange of the Higgs boson within the framework of the Next-to-Minimal Supersymmetric Standard Model (NMSSM). The hadronic equation of state (EOS) is modelled using the relativistic mean-field (RMF) formalism with IOPB-I, G3, and quark–meson coupling (QMC)-RMF series parameter sets. The presence of DM softens the EOS at both the background and the perturbation levels that implies a small shift to the left in the posterior accompanied by a much larger jump in the left of the mass–radius curves with increasing DM mass. It is observed that EOSs with DM also satisfy the C–Λ universality relations among themselves but get slightly shifted to the right in comparison to that without considering DM. Additionally, we find that the inclusion of DM allows the mass–radius (M–R) curves to remain consistent with observational constraints for HESS J1731−347, indicating the possibility of classifying it as a dark matter-admixed neutron star (DMANS). Moreover, we explore the impact of DM on the radial oscillations of pulsating stars and investigate the stability of NSs. The results demonstrate a positive correlation between the mass of DM and the frequencies of radial oscillation modes.
Lymphopenia is a risk factor for severe infections in older patients with microscopic polyangiitis: a retrospective cohort study in Japan
Authors: Yamaguchi Makoto , Sugiyama Hirokazu , Nobata Hironobu , Kinashi Hiroshi , Asai Akimasa , Kitamura Fumiya , Katsuno Takayuki , Ando Masahiko , Kubo Yoko , Banno Shogo , Ito Yasuhiko , Ishimoto Takuji 
Published: August 2023

Abstract

Objective
Previous studies have identified the predictors of severe infections in ANCA-associated vasculitis. However, lymphopenia has not been fully evaluated as a predictor of subsequent severe infections in patients with microscopic polyangiitis (MPA). The aim of this study was to assess the association between lymphopenia and severe infections requiring hospitalization after receiving immunosuppressive therapy for MPA.

Methods
This single-centre retrospective cohort study included 130 consecutive patients with newly diagnosed MPA from Aichi Medical University Hospital, Japan, who received immunosuppressive therapy between March 2004 and December 2020. The relationship between lymphopenia and subsequent severe infections was assessed using time-dependent multivariate Cox proportional hazard models adjusted for clinically relevant factors.

Results
During the follow-up period (median: 38 months; interquartile range: 15–63 months), 56 severe infectious episodes occurred in 51 patients (39.2%). Time-dependent multivariate Cox proportional hazard analyses identified older age [adjusted hazard ratio (HR) = 1.74 per 10 years, 95% CI: 1.13, 2.67], methylprednisolone pulse therapy (adjusted HR = 2.04, 95% CI: 1.03, 4.02), moderate lymphopenia (vs normal, adjusted HR = 7.17, 95% CI: 3.10, 16.6) and severe lymphopenia (vs normal, adjusted HR = 36.1, 95% CI: 11.8, 110.9) as significant predictors of severe infection.

Conclusion
Lymphopenia is a predictor of subsequent severe infections in patients with MPA who receive immunosuppressive therapy. These results suggest the importance of sustained infection surveillance, particularly in older patients who develop lymphopenia during strong immunosuppressive therapy.
Scale or Yield? A Present-Value Identity
Authors: Cho Thummim , Kremens Lukas , Lee Dongryeol , Polk Christopher 
Published: August 2023

Abstract
We propose a loglinear present-value identity in which investment (“scale”), profitability (“yield”), and discount rates determine a firm’s market-to-book ratio. Our identity reconciles existing influential market-to-book decompositions and facilitates novel insights from three empirical applications: (1) Both investment and profitability are important contributors to the value spread and stock return news variance. (2) Any cross-sectional return predictability has a mirror image in cash-flow fundamentals, providing asset pricing theories with additional moments to match. (3) The investment spread significantly improves the predictability of time-series variation in the value premium and justifies the poor performance of value in recent years.
Body composition parameters in systemic sclerosis—a systematic review and meta-analysis
Authors: Radić Mislav , Kolak Ela , Đogaš Hana , Gelemanović Andrea , Bučan Nenadić Dora , Vučković Marijana , Radić Josipa 
Published: August 2023

Abstract

Background
The aim of this systematic review and meta-analysis was to summarize current evidence regarding body composition (BC) in SSc in order to gain new insights and improve clinical care in the context of the nutritional status of SSc patients.

Methods
The databases Web of Science, PubMed, Scopus and Cochrane Library were searched on 4 January 2023. Studies were included if they provided data regarding BC obtained by dual-energy X-ray absorptiometry (DXA) or bioelectrical impedance analysis (BIA) in patients with SSc and healthy controls (HC). The study design criteria for inclusion were cohort and observational studies. The risk of bias assessment was performed using the Newcastle–Ottawa scale. For meta-analysis, mean difference with a 95% confidence interval was obtained and all results were depicted as forest plots.

Results
The number of retrieved publications was 593, of which nine were included in a random-effects meta-analysis totalling 489 SSc patients and 404 HC. Overall, significantly lower body mass index, lean mass (LM), fat mass (FM) and phase angle values were found in SSc patients when compared with HC. Furthermore, FM and LM were significantly lower in SSc patients when the DXA method was applied, whereas the same parameters were comparable between two groups of participants when BIA was applied.

Conclusion
Altered BC is characteristic of SSc patients indicating the need for regular nutritional status assessment in order to improve the quality of life and clinical care of patients with SSc.