bluuebunny/crossref_metadata_2025_split huggingface dataset:
Withdrawal of life‐sustaining treatment in Japanese home care: A cross‐sectional survey
Authors: Takeshita Kei , Nagao Noriko , Dozono Toshihiko , Kamiya Keiko , Miura Yasuhiko 
Published: January 2025

AbstractBackgroundIn Japan, legal and social concerns exist about withdrawing life‐sustaining treatment (LST) even at the end of life. This study aimed to investigate the experience of physicians and nurses involved in home care with LST withdrawal.MethodsA web‐based questionnaire survey was conducted among physicians and nurses who were members of the Japanese Association for Home Care Medicine in 2020. The survey collected data on the experience of respondents with withdrawing LST, the decision‐making processes involved in withdrawing treatment, and their experience with patients attempting voluntarily stopping eating and drinking (VSED).ResultsResults from 203 respondents, including 150 physicians and 53 nurses, showed that the most commonly withdrawn LSTs were intravenous infusions (115 respondents), tube feeding (69 respondents), and oral administration of medicine (74 respondents). A few respondents withdrew respiratory management, such as mechanical ventilation (11 respondents) or home oxygen therapy (12 respondents). The main diagnoses of patients who had LSTs withdrawn were malignancy, senility, and dementia. Many respondents made decisions through discussions with the families of patients (117 respondents) or multidisciplinary discussions at their facilities (80 respondents). There were 23 respondents who made the decision alone, and they were all physicians. Thirty‐two respondents had experience with patients who had completed VSED.ConclusionIt was found that many Japanese home care physicians and nurses had experienced withdrawal of LSTs, and a significant number among them had experienced patients attempting VSED. Given this situation, there is an urgent need to provide ethics support in Japanese home care.
A fundamental rheological approach to determine the optimum water absorption capacity of a model gluten‐free dough system: soy flour dough
Authors: Yazar Gamze 
Published: January 2025

AbstractBACKGROUNDDetermining the optimum water absorption capacity of gluten‐free flours for an improved breadmaking process has been a challenge because there is no standard method. In the present study, large amplitude oscillatory shear (LAOS) tests were performed to explore the impact of different levels of added water on non‐linear viscoelastic response of soy flour dough in comparison to wheat flour dough at a consistency of 500 BU.RESULTSAmong the LAOS parameters, large strain modulus (G′L) and large strain rate viscosity (η′L) were found to better probe the impact of added water amount on non‐linear viscoelastic properties of soy flour dough. Although soy flour dough with 160:100 (water: soy flour, v/w) and wheat flour dough had overlapping η*(ω) in the linear viscoelastic region, LAOS sweeps revealed similar tan δ, G′L and η′L values along with similar elastic and viscous Lissajous–Bowditch curves at γ0 = 200% for soy flour dough with 175:100 (water: soy flour, v/w) to those of wheat flour dough.CONCLUSIONConsidering the large deformations involved in breadmaking process and the poor capability of the linear viscoelastic measures to predict loaf volume, the present study suggests using the LAOS parameters to determine the optimum water absorption capacity and to optimize the strain‐stiffening and shear‐thinning behaviors of gluten‐free flours to improve end‐product quality. © 2025 Society of Chemical Industry.
Eco‐Friendly and Green Biochar Sorbent–Extraction Techniques for Pharmaceuticals, Environmental, and Food Analysis—A Review
Authors: Khan Wajid Ali , Arain Muhammad Balal , Balal Sana , Niaz Abdul , Mollahosseini Afsaneh , Soylak Mustafa 
Published: January 2025

ABSTRACTThe most important aspect of sorbent‐based approaches is the use of a sustainable, readily available, and cost‐effective sorbent material for sample analysis. Biochar is an emerging and prominent sorbent material for various applications in sorbent‐based techniques due to its availability, affordability, eco‐friendly nature, porosity, pore structure, abundance of aliphatic and aromatic carbon structures, and abundant oxygen‐containing functional groups. On the basis of the numerous benefits of biochar, this review discusses why biochar is the preferred sorbent in sorptive‐based techniques. In addition, this review provides a brief evaluation of various biochar‐based sorptive approaches, including biochar‐based solid‐phase extraction (SPE)/microextraction (SPME), magnetic SPE/SPME, in‐tube SPME, pipette‐tip micro SPE, and thin‐film microextraction. Furthermore, each section briefly overviews various studies for various sample analyses and applications, including pharmaceuticals, environmental, and food. Most importantly, on the basis of the literature review, biochar is an emerging sorbent material for various sorbent‐based techniques that require further investigation for various applications.
Experimental Emulator of Pulse Dynamics in Fractional Nonlinear Schrödinger Equation
Authors: Liu Shilong , Zhang Yingwen , Virally Stéphane , Karimi Ebrahim , Malomed Boris A. , Seletskiy Denis V. 
Published: January 2025

AbstractA nonlinear optical platform is presented to emulate a nonlinear Lévy waveguide that supports the pulse propagation governed by a generalized fractional nonlinear Schrödinger equation (FNLSE). This approach distinguishes between intra‐cavity and extra‐cavity regimes, exploring the interplay between the effective fractional group‐velocity dispersion (FGVD) and Kerr nonlinearity. In the intra‐cavity configuration, stable fractional solitons enabled by an engineered combination of the fractional and regular dispersions in the fiber cavity are observed. The soliton pulses exhibit their specific characteristics, viz., “heavy tails” and a “spectral valley” in the temporal and frequency domain, respectively, highlighting the effective nonlocality introduced by FGVD. Further investigation in the extra‐cavity regime reveals the generation of spectral valleys with multiple lobes, offering potential applications to the design of high‐dimensional data encoding. To elucidate the spectral valleys arising from the interplay of FGVD and nonlinearity, an innovative “force” model supported by comprehensive numerical analysis is developed. These findings open new avenues for experimental studies of spectral‐temporal dynamics in fractional nonlinear systems.
Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3
Authors: Kuang Wenhua , Zhuge Ruishen , Song Ping , Yi Letai , Zhang Shujie , Zhang Ying , Wong Yin Kwan , Chen Ruixing , Zhang Junzhe , Wang Yuanbo , Liu Dandan , Gong Zipeng , Wang Peili , Ouyang Xiangying , Wang Jigang 
Published: January 2025

AbstractPeriodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug for cancers and immune disorders. Here, we explored the ameliorative effects and underlying molecular mechanism of EB on periodontitis for the first time. We demonstrated that EB ameliorates periodontal inflammation and alveolar bone resorption with a ligated periodontitis mouse model. In addition, the impact of EB on macrophages inflammation was examined in the Raw264.7 cell line. We identified ubiquitin‐conjugating enzyme, UBE2D3, as the direct covalent binding protein targets of EB by using a chemoproteomic method based on activity‐based protein profiling, biolayer interferometry method, and cellular thermal shift assay. Furthermore, the direct binding site of EB to UBE2D3 was identified using high‐resolution mass spectrometry and confirmed by experiments. Taken together, EB ameliorates periodontitis by targeting UBE2D3 to suppress the ubiquitination degradation of IκBα, leading to inactivation of nuclear transcription factor‐κB signaling pathway. And this was confirmed by siRNA‐mediated gene knockdown in inflammatory macrophages. Our results suggested that EB may be a new kind of UBE2D3 inhibitor and may become a promising therapeutic agent for anti‐periodontitis.
‘A deep, empathetic, wondrous connection’: Autistic adults' definitions and experiences of nature connection
Authors: Friedman Samantha , McHaffie Sara , Noble Roan , Stenning Anna 
Published: January 2025

Abstract

Connection to nature is an important concept for understanding human‐nature relationships, interests in nature and pro‐environmental behaviours. However, conceptualisations of this relationship thus far have excluded autistic perspectives.

Through this reflexive thematic analysis of survey responses from 108 autistic participants in the UK, we sought to understand how autistic people define and experience connection to nature.

Towards this aim, we developed three themes: ‘feeling that you benefit nature and nature benefits you’; ‘connecting with something ancient to which I nevertheless belong’; and ‘it makes me a little sad tbh.’ Across many participants in this sample, nature was not something they saw as separate from themselves (or from humans more generally), and so connection to nature was not a simple, unidirectional relationship nor a clear‐cut binary.

Through this work, we hope to contribute towards the effort to imbue ecopsychology and related fields with the influences of critical disability studies.

Read the free Plain Language Summary for this article on the Journal blog.
Registration of ‘Avant’ rice
Authors: Angira Brijesh , Linscombe Steve , Webster Connor , Kongchum Manoch , Dalla‐Lana Felipe , Wilson Blake , Zaunbrecher Richard E. , Dartez Valerie , Williams Brady , Theunissen Brent , Famoso Adam N. 
Published: January 2025

Abstract‘Avant’ (Reg. no. CV‐161; PI 699954), an early‐maturing and high‐yielding long‐grain rice (Oryza sativa L.) cultivar, was developed by the Louisiana State University Agricultural Center at the H. Rouse Caffey Rice Research Station near Crowley, LA, and was approved for release in 2021. Avant was selected from the cross ‘Trenasse’//‘Cocodrie’/‘Jefferson’/3/‘Ahrent’/‘Cocodrie’// Cocodrie/‘LaGrue’. It demonstrated good yield potential and favorable agronomic characteristics in the 2017 preliminary yield trial. From 2018 to 2023, Avant underwent evaluation in 54 replicated trials across nine locations in Louisiana. Four high‐yielding commercial cultivars were included as checks: ‘Mermentau’, ‘Cheniere’, ‘CL153’, and ‘CLL17’. The grain yield of Avant was 9.5 t ha−1 compared to 9.3 t ha−1 for Mermentau, 8.8 t ha−1 for Cheniere, 9.5 t ha−1 for CL153, and 9.3 t ha−1 for CLL17 across 46 trials from 2018 to 2023. Avant was significantly shorter than Mermentau, Cheniere, CL153, and CLL17. It exhibits cooking quality similar to typical US long‐grain rice. Avant is susceptible to sheath blight, moderately susceptible to leaf blast and bacterial panicle blight, and moderately resistant to narrow brown leaf spot.
Highly Simplified FeCl3‐Assisted Copolymerization and Doping for Organic Thermoelectrics
Authors: Kim Hyeokjun , Lee Taek Seong , Kim Haeseong , Shin Jiyoung , Baek Jisu , Jang Jaeyoung , Jung In Hwan 
Published: January 2025

ABSTRACTThe FeCl3 is a well‐known oxidizing agent for oxidative polymerization as well as a p‐type dopant for making conducting polymers, but no studies have yet explored the simultaneous use of FeCl3 for both polymerization and doping of organic soluble conjugated polymers (CPs) in organic thermoelectric (OTE) applications. In this study, soluble 4H‐cyclopenta[2,1‐b:3,4‐b′]dithiophene (CPDT)‐co‐3,4‐ethylenedioxythio‐phene (EDOT) polymers were successfully synthesized via a simple FeCl3‐assisted oxidative coupling reaction at room temperature. In addition, FeCl3 doping of the synthesized polymers enabled them to exhibit thermoelectric properties. The addition of 10% ~ 20% EDOT in a polymer chain gave a synergetic effect on the electrical conductivity and power factor (PF) in the OTE devices. In that ratio, the strong electron‐donating EDOT facilitates doping in the CPs, and the planar CPDT backbones stabilize the generated polaron/bipolaron species through efficient π‐electron delocalization, resulting in the highest electrical conductivity. At the optimal EDOT ratio of 20%, a more than 10‐fold enhancement in PFs was achieved reaching up to 0.182 ± 0.021 μW m−1 K−2. The EDOT moiety, except in PEDOT:PSS, is rarely found in conjugated copolymers, but its proper incorporation is expected to enhance thermoelectric properties of the organic soluble CPs.
Development and Validation of a Predictive Model of Prostate Screening Compliance: A Nationwide Population‐Based Study
Authors: Arriaga‐Izabal Diego , Morales‐Lazcano Francisco , Canizalez‐Román Adrian 
Published: January 2025

ABSTRACTIntroductionProstate cancer (PCa) is the second most common cancer in men worldwide, with significant incidence and mortality, particularly in Mexico, where diagnosis at advanced stages is common. Early detection through screening methods such as digital rectal examination and prostate‐specific antigen testing is essential to improve outcomes. Despite current efforts, compliance with prostate screening (PS) remains low due to several barriers. This study aims to develop and validate a predictive model for PCa screening compliance in Mexican men.Materials and MethodsRetrospective observational design with data from the Mexican Health and Aging Study (MHAS). Participants were men aged 50–69 from three cohorts: development/internal validation, temporal validation, and external validation. Key predictors were identified using relaxed Least Absolute Shrinkage and Selection Operator (LASSO) regression, and model performance was assessed using the area under the curve (AUC) from receiver operating characteristic (ROC) analyses, along with calibration and decision curve analysis (DCA). A web nomogram was also developed.ResultsThe final model included seven key predictors. AUC values indicated good predictive performance: 0.783 for the training subgroup, 0.722 for the test subgroup, 0.748 for the time cohort, and 0.756 for the external cohort, with sensitivities of 73.5%. The DCA demonstrated the superior clinical utility of the model compared to the reference strategies.ConclusionsThe predictive model developed for performance to PCa screening is robust across different cohorts and highlights critical factors influencing performance. The accompanying web‐based nomogram enhances clinical applicability and supports interventions aimed at improving PCa screening rates among Mexican men.
Cardiac Cachexia and the Associations to the Microbiome: State‐of‐the‐Science Review
Authors: Anderson Kelley M. , Schmitt Amanda , Weintraub William S. , Scally Rebecca , Steen Tomoko Y. 
Published: January 2025

ABSTRACTBackgroundCardiac cachexia is a late manifestation of advanced heart failure, with a 5%–15% prevalence. A diagnosis of cardiac cachexia is not simply another complication of heart failure; clinical consequences of cachexia are impaired physical function, fatigue, poor quality of life and independently associated with heart failure severity, adverse cardiovascular and non‐cardiovascular outcomes, longer length of hospital stays and increased mortality. Although it is well established that cardiac cachexia is associated with poor outcomes, there remains a lack of evidence describing the underlying mechanisms that has resulted in limited impactful treatment modalities. Contemporary explorations describe the association of the gut microbiome related to many health conditions, including heart failure. Preclinical and clinical studies are defining the role of the microbiome and the associations to heart failure and comorbidities including cardiac cachexia.MethodsIn this review, we summarize the relevant literature to (1) describe the diagnosis and evaluation of cachexia in individuals with heart failure; (2) provide an overview of the heart–gut axis; (3) report on the gut microbiome as a mediator of cardiac cachexia with a focus on inflammation and protein loss; (4) detail the clinical characterizations and manifestations of cardiac cachexia; (5) review current treatment modalities for cardiac cachexia and their limitations; and (6) provide recommendations for future lines of inquiry for heart failure–related cachexia and the microbiome.ResultsCurrent clinical and animal studies are developing the science to expand our understanding of the association of the microbiome to the clinical expression of cardiovascular conditions, including heart failure and related conditions, including cachexia. Elucidating mechanisms of cachexia will provide the foundational evidence to improve treatment approaches. Available treatments are limited and do not meaningfully impact the illness experience of patients with heart failure and cachexia. Improving our understanding of the innovative concept of the heart–gut axis has the potential for significant clinical advances in developing novel diagnostic and therapeutic approaches for heart failure and for evaluating a common pathway for cachexia.ConclusionsIn this review, we discuss the characteristics, evaluation, impact on prognosis and therapeutic interventions of cachexia and the current state of the science related to the role of the microbiome in cardiac cachexia. Although the current evidence is limited, there are numerous opportunities for collaborative efforts among translational researchers to understand the underlying mechanisms of cardiac cachexia and the relationship to the gut microbiome and to develop innovative therapeutic treatment interventions for patients with advanced heart failure.
Robust Fault Detection for Fuzzy‐Model‐Based Networked Control Systems Under Denial‐of‐Service Attacks and Sensor Faults Within a Stochastic Communication Protocol
Authors: Ding Tongtong , Tan Cheng , Chen Ziran , Sun Hongtao 
Published: January 2025

ABSTRACTThis paper investigates the robust fault detection problem in non‐linear networked systems, characterized by the Takagi‐Sugeno (T‐S) fuzzy model. The analysis is complicated by Denial‐of‐Service (DoS) attacks and sensor faults. In such systems, DoS attacks disrupt network communications, threatening both system stability and fault detection accuracy. Simultaneously, sensor faults compromise the reliability of the system's measurement outputs. To address these challenges, the stochastic communication protocol (SCP) is employed to optimize the transmission order between multiple sensors and the fault detector, effectively managing the limitations of communication capacity. Consequently, a fault detection scheme based on SCP is developed to generate residual signals, supported by an auxiliary residual system for stability analysis. Using the Lyapunov‐Krasovskii (L‐K) functional approach, sufficient conditions are derived to ensure the asymptotic stability of the residual system with a prescribed performance. Finally, the effectiveness of the proposed fault detection scheme is validated through simulation examples.
Unveiling the Role Reversal of Guest and Host in OverTolerant Hybrid Perovskites
Authors: Srivastava Pradhi , Maity Sayan , Srinivasan Varadharajan 
Published: January 2025

AbstractThe structural and electronic changes are investigated in a 3D hybrid perovskite, methylhydrazinium lead chloride (MHyPbCl3) from a host/guest perspective as it transitions from a highly polar to less polar phase upon cooling, using first‐principles calculations. The two phases vary structurally in the guest (MHy) orientation and the two differently distorted host (lead halide) layers. These findings highlight the critical role of guest reorientation in reducing host distortion at high temperatures, making the former the primary order parameter for the transition, a notable contrast to the case of other hybrid perovskites. This is also confirmed by the dominating contribution of guest reorientation along the transition pathway. Analysis using maximally localized Wannier functions reveals that polarization enhancement upon heating is primarily due to host atoms, particularly of the more distorted octahedral layer. Despite its pivotal role in the transition, the contribution of the guest to polarization is relatively weaker, in contrast to previous suggestions. Furthermore, host distortion induces a significant (∼9%) feedback polarization on the guest. This distortion is also responsible for significantly altering the density of states occupied by the guest closer to band‐edges, suggesting a non‐trivial contribution of the guest in impacting the optoelectronic properties and exciton binding energies.
Mesoscale Filamentous Polyelectrolytes: Chemical Functionalization and Fluidic Structure
Authors: Meissner Cornelia , Crosby Alfred J. , Emrick Todd 
Published: January 2025

AbstractThe preparation and study of synthetic mesoscale structures opens opportunities to understand soft materials properties at length scales that are intermediate between that of the molecular and bulk, often referred to as the mesoscale. This paper details the preparation of mesoscale polymer filaments, prepared by flow coating and evaporative deposition from solution to yield filamentous versions of charged polymers. Using thiol‐ene reactions on olefin‐containing mesoscale polymer ribbons, anionic character in the form of carboxylates is introduced to the filamentous structures. The resultant mesoscale ribbons exhibit morphological changes as a function of their aqueous solution environment, based on their neutral versus anionic character, offering insights into the structure and morphology of small, multi‐length scale, soft structures comprised of macromolecular materials.
A Streamlined Approach to Anticounterfeiting Technologies: Patterned AAO Membranes Based on Photonic Crystal Effects with Tunable Color Shifts and pH Responsiveness
Authors: Lin Yu‐Chun , Lee Lin‐Ruei , Tsai Tsung‐Hung , Lin Ji , Hsu Yen‐Shen , Kesavan Manibalan , Lin Yu‐Liang , Chen Yi‐Fan , Chen Jiun‐Tai 
Published: January 2025

AbstractAnticounterfeiting technologies have become increasingly crucial due to the growing issue of counterfeit goods, particularly in high‐value industries. Traditional methods such as barcodes and holograms are prone to replication, prompting the need for advanced, cost‐effective, and efficient solutions. In this work, a practical application of anodic aluminum oxide (AAO) membranes are presented for anticounterfeiting, which addresses the challenges of high production costs and complex fabrication processes. Unlike previous approaches requiring metal coatings for color generation, this method uses commercial aluminum foils to produce colorful AAO membranes without metal layers. Elemental mapping suggests that impurities on the aluminum surface contribute to enhanced reflectivity, aiding photonic crystal formation. A two‐step anodization process that creates patterned AAO membranes is further introduced, with the pattern clarity controlled by anodization time. Additionally, a pH‐responsive film composed of 2‐anilino‐6‐dibutylaminofluoran (ODB‐2) and thermoplastic polyurethane (TPU) is integrated, enabling dynamic color changes under varying pH conditions, further enhancing the anticounterfeiting functionality. This streamlined approach provides a scalable and cost‐effective solution for developing versatile AAO membranes for industrial anticounterfeiting applications.