bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-transplantation cyclophosphamide combined with tacrolimus and low-dose post-engraftment anti-thymoglobulin as GVHD prophylaxis for patients undergoing peripheral blood stem cell transplantation from haploidentical family donor: A single center analysis
Authors: Gao Wen-hui , Zhu Jia-yan , Wang Li-ning , Wan Ming , Wang Ling , Devillier Raynier , Jiang Jie-ling , Blaise Didier , Hu Jiong 
Published: March 2023

IntroductionPost-transplantation cyclophosphamide (PT-Cy) use is a recent graft-versus-host disease (GVHD) prophylaxis strategy for patients undergoing allogeneic stem cell transplantation (allo-HSCT). PT-Cy combined with two immunosuppressants is now widely used after haplo-identical (haplo) and HLA-matched peripheral blood stem cell (PBSC) transplantations with promising GVHD and relapsefree survival (GRFS) probabilities. Although appealing, these results may benefit from improvement notably outside matched sibling donor transplantation, and should be investigated in various ethnic populations.MethodsTherefore, we report our experience of GVHD prophylaxis regimen combining PT-Cy and tacrolimus with addition of post-engraftment low-dose anti-thymocyte globulin (ATG) in allogeneic stem cell transplantation from haplo-identical donors (Haplo). Sixtyseven patients were included in the analysis. All patients received myeloablative or intensified sequential conditioning regimen.ResultsThe median follow-up was 521 (range, 10~991) days. The cumulative incidences of 100-day grade II-IV acute GVHD was 14.9±4.4%, and no case of grade III-IV acute GVHD was documented. The cumulative incidences of 2-yearchronic GVHD and moderate-to-severe chronic GVHD were 25.4±5.4% and 11.9±4%, respectively. The non-relapse mortality at day+100 and 2year were 7.5±3.2% and 9.0±3.5%, respectively. The cumulative incidence of relapse at 2year was 16±6.4%. The 2-year probability of DFS and OS were 73.8% (95%CI, 61.5~88.4%) and 72.5% (95% CI, 57.1~92.1%), respectively. The 2-year GRFS was estimated as 63.6% (95%CI, 50.6~80%).DiscussionOur results suggested that a combination of PT-Cy, tacrolimus, and low-dose post-engraftment ATG was a promising GVHD prophylaxis with low incidence of acute GVHD in the haplo-transplantation setting.
No association of the dopamine D2 receptor genetic bilocus score (rs1800497/rs1799732) on food addiction and food reinforcement in Chilean adults
Authors: Hidalgo Vira Nicole , Oyarce Karina , Valladares Vega Macarena , Goldfield Gary S. , Guzmán-Gutiérrez Enrique , Obregón Ana M. 
Published: March 2023

Purpose: Different systems regulate food intake. In the reward system, dopamine (DA) is the main neurotransmitter, and a variety of genetic variants (rs1799732 and rs1800497) are associated with addiction. Addiction is a highly polygenic disease, where each allelic variant adds a small amount of vulnerability. Polymorphisms rs1799732 and rs1800497 are associated with eating behavior and hedonic hunger, but links to food addiction remain unclear.Aim: To evaluate the association between the bilocus profile (rs1799732-rs1800497) of the dopaminergic pathway with food reinforcement and food addiction in Chilean adults.Methods: A cross-sectional study recruited a convenience sample of 97 obese, 25 overweight, and 99 normal-weight adults (18–35 years). Anthropometric measurements were performed by standard procedures and eating behavior was assessed using the: Food Reinforcement Value Questionnaire (FRVQ) and Yale Food Addiction scale (YFAS). The DRD2 genotypes were determined by TaqMan assays (rs1800497 and rs1799732). A bilocus composite score was calculated.Results: In the normal weight group, individuals who were heterozygous for the rs1977932 variant (G/del) showed higher body weight (p-value 0.01) and abdominal circumference (p-value 0.01) compared to those who were homozygous (G/G). When analyzing rs1800497, a significant difference in BMI was observed for the normal weight group (p-value 0.02) where heterozygous showed higher BMI. In the obese group, homozygous A1/A1 showed higher BMI in comparison to A1/A2 and A2/A2 (p-value 0.03). Also, a significant difference in food reinforcement was observed in the rs1800497, where homozygous for the variant (A1A1) show less reinforcement (p-value 0.01).In relation to the bilocus score in the total sample, 11% showed “very low dopaminergic signaling”, 24.4% were “under”, 49.7% showed “intermediate signaling”, 12.7% showed “high” and 1.4% showed “very high”. No significant genotypic differences were observed in food reinforcement and food addiction by bilocus score.Conclusions: The results indicate that the genetic variants rs1799732 and rs1800497 (Taq1A) were associated with anthropometric measurements but not with food addiction or food reinforcement in Chilean university students. These results suggest that other genotypes, such as rs4680 and rs6277, which affect DA signaling capacity through a multilocus composite score, should be studied. Level V: Evidence obtained from a cross-sectional descriptive study.
Association between CORIN promoter methylation and stroke: Results from two independent samples of Chinese adults
Authors: Chen Linan , Jiang Jun , Yao Jialing , Lu Ying , Zhang Xiaolong , Zhang Mingzhi , Zhang Qiu , Peng Hao 
Published: March 2023

ObjectiveAs the physical activator of natriuretic peptides, corin has been associated with stroke, but the underlying mechanism is not very clear. Here, we examined whether the CORIN promoter’s methylation, an epigenetic DNA modification, was associated with the risk of stroke in two independent samples.MethodsA total of 1771 participants including 853 stroke cases and 918 healthy controls were included as a discovery sample and 2,498 community members with 10 years of follow-up were included as a replication sample. DNA methylation of the CORIN promoter was quantified by target bisulfite sequencing in both samples. We first examined the single CpG association, followed by a gene-based analysis of the joint association between multiple CpG methylation and stroke, adjusting for conventional risk factors.ResultsThe single CpG association analysis found that hypermethylation at all of the 9 CpG sites assayed was significantly associated with lower odds of prevalent stroke in the discovery sample (all p &lt; 0.05), and three of them located at Chr4:47840038 (HR = 0.74, p = 0.015), Chr4:47839941 (HR = 0.80, p = 0.047), and Chr4:47839933 (HR = 0.82, p = 0.050) were also significantly associated with incident stroke in the replication sample. The gene-based association analysis found that DNA methylation of the 9 CpG sites at the CORIN promoter was jointly associated with stroke in both samples (all p &lt; 0.05).ConclusionDNA methylation levels of the CORIN gene promoter were lower in stroke patients and predicted a higher risk of incident stroke in Chinese adults. The underlying causality warranted further investigation.
Clinical features and familial mutations in the coexistence of Wilson's disease and Alport syndrome: A case report
Authors: Wang Ying , He Qingnan , Dang Xiqiang , Wu Xiaochuan , Li Xiaoyan 
Published: March 2023

BackgroundAlport syndrome (AS) and Wilson's disease (WD) are genetic diseases that could lead to kidney damage. Herein, we report the clinical features and gene variants in a patient with WD and X-linked AS.Case presentationThe proband was a 12-year-old boy diagnosed with AS coexisting with WD at the age of 11 years. The patient underwent a medical check-up when he was 4 years and 8 months. Laboratory tests revealed elevated liver enzymes, decreased serum ceruloplasmin, increased 24-h urinary copper excretion, and one variant in the ATP7B gene. Then, the patient was diagnosed with WD. After 2 months of treatment with D-penicillamine and zinc salt, his liver function had recovered to normal levels, but he presented with microscopic hematuria. The hematuria did not resolve after switching to dimercaptosuccinic acid from D-penicillamine. In addition, he presented with proteinuria 3 years later. A renal biopsy was performed more than 6 years after the patient was diagnosed with WD, and electron microscopy showed that the basement membrane thickness was uneven, layered, and focal torn. Copper staining was negative. A genetic analysis identified a hemizygous variant (c.1718G &gt; A, p. Gly573Asp) in COL4A5 and a homozygous variant (c.2975C &gt; T, p. Pro992leu) in ATP7B. The patient’s urine protein–creatinine ratio was less than 1.0 mg/mg after a 1 year of follow-up, after enalapril was administered for treating AS.ConclusionThis case highlights a lack of improvement in renal function after conventional treatment provides a possible indication for performing renal biopsy or genetic testing to determine the etiology in order to facilitate subsequent clinical management. Clinicians should prevent the occurrence of diagnostic inaccuracies caused by diagnostic anchoring because an accurate diagnosis is essential for achieving precise treatment and improved prognosis.
Psychometric properties of the post-stroke depression scale in the sequelae stage
Authors: Zeng Yawei , Li Fengzhen , Ning Liuqiao , Fu Yingjie , Ge Yajing , Gan Beibei , Lin Suichai , Lin Haiyun , Li Jufang 
Published: March 2023

AimTo evaluate the psychometric properties of the Post-Stroke Depression Scale in the Sequelae Stage (PSDS-SS).BackgroundThe incidence of the sequelae stage Post-Stroke Depression (PSD) is high, and the best screening tools are still lacking. Under this circumstances, our research team developed the PSDS-SS by Delphi method, but its psychometric properties need to be further verified.MethodThis was a cross-sectional study. Seven hundred and sixteen stroke patients in the sequelae stage were enrolled by purpose sampling from May 2022 to September 2022. The exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to verify the factor structure of the scale. The reliability of the scale was tested by Cronbach’s α coefficient, test–retest reliability and composite reliability. The validity of the scale was tested by criterion-related validity, convergent and discriminant validity.ResultEight items were deleted through item analysis. The EFA ended up with a 5-factor scale including 24 items after removing one item with low factor loading. Finally, a 21-item model was established by confirmatory factor analysis, and all the fit indexes were acceptable. The reliability and validity of the total scale and each factor are acceptable.ConclusionThe PSDS-SS has a stable factor structure, and demonstrated good reliability and validity. And it would be an effective tool to assess PSD in the sequelae stage.
Resolution of paraneoplastic hypoglycemia following nephroureterectomy for treatment of canine renal cell carcinoma: Case report
Authors: Huerta Yael , Lenz Jennifer , Flesner Brian , Abrams Brittany , Amerman Hayley , Griffin Maureen 
Published: March 2023

ObjectivesTo describe the clinicopathologic findings, imaging results, surgical treatment, and outcome of a dog with renal cell carcinoma (RCC) and paraneoplastic hypoglycemia.AnimalsA 13-year-old female spayed mixed breed dog that was presented for facial twitching and neurologic decline and diagnosed with a renal mass and paraneoplastic hypoglycemia.Study designCase report.MethodsSerum chemistry revealed severe hypoglycemia and normal renal values. Abdominal ultrasonography showed a large, heterogeneous, cavitated mass associated with the left kidney and no evidence of abdominal metastatic disease. Thoracic radiographs revealed no evidence of pulmonary metastatic disease. Fasted serum insulin was low concurrently with severe hypoglycemia. No other causes of hypoglycemia were detected, and paraneoplastic hypoglycemia was suspected.ResultsAfter initial medical management of the dog's hypoglycemia, left nephroureterectomy was performed. Histopathology was consistent with RCC. Postoperatively, the dog's hypoglycemia resolved, and supplementation was discontinued. The dog remained stable and was discharged from the hospital 3 days after surgery. At 2-week, 3-month, and 5-month follow up evaluations, the dog remained euglycemic, and no definitive evidence of disease progression was detected. Eight months postoperatively, the dog was euthanized due to decline in mobility. Necropsy and histopathology revealed cerebral and spinal cord multifocal myelin sheath dilation and two primary pulmonary carcinomas with no evidence of recurrence or metastasis of the RCC.ConclusionSurgical treatment of RCC with subsequent resolution of paraneoplastic hypoglycemia has not previously been reported in veterinary medicine. In this dog, nephroureterectomy for RCC resulted in immediate and sustained resolution of paraneoplastic hypoglycemia.
Hydraulic Characterization of Ceramic Foam Filters Used in Aluminum Filtration
Authors: Hassanabadi Massoud , Berto Thomas , Akhtar Shahid , Aune Ragnhild E. 
Published: March 2023

Ceramic Foam Filters (CFF) are frequently used during the filtration of aluminum (Al) melts to produce high-quality products. In the present study, the physical and hydraulic characteristics of alumina (Al2O3)-based CFF from three different suppliers (A, B and C) have been thoroughly investigated. The filters’ porosity and pore diameter, i.e., Window and Cell Feret diameters, were measured and the permeability of the different filters calculated based on pressure drop experiments. The comparison of the classification systems of CFF, i.e., Grade and PPI (Pore Per Inch) numbers, using statistical analysis of permeability and Window Feret diameter showed significant variations between the morphological and hydraulic properties of some CFFs of identical Grade and PPI numbers. Moreover, the Fanning friction factor was plotted as a function of interstitial Reynolds numbers (Rei), and laminar, transient, and turbulent flow regimes were identified. The relationship between the Fanning friction factor and the interstitial Reynolds numbers of all the filter samples investigated was processed using regression analysis, and a model equation developed to calculate the pressure drop over the CFF using the Window Feret diameter. The correlation between the experimental pressure drop values and the derived model equation indicates that empirical expressions for calculating the pressure drop over CFFs should be derived based on experimental measurements carried out at the velocity range of the application of the CFF, which is about 10 mm·s−1 for aluminum filtration.
In-process Profiling of Herbomineral Formulation from Marine Origin
Authors: Rasheed Shebina P. , Shivashankar Murugesh 
Published: March 2023

Objectives: To prepare Shankha Bhasma, an antiulcer formulation from marine origin and to standardize the formulation by two different methods of preparation and to compare with marketed formulation by modern scientific tools
Methods: Shankha Bhasma was prepared from conch shell by open and closed methods using adjuvants Kumari Swarasa and water and subjected to characterization by conventional method and AAS, XRD, EDAX, SEM, TEM, BET, TGA, IR spectroscopy. The effectiveness was checked by animal studies, toxicity by histopathology and cytotoxicity studies.
Results: Open method takes few steps and less time and shows crystalline nature (XRD).TGA shows the decomposition temp of calcium oxide. The closed method produces smoother particle (SEM,TEM and BET) with no peaks for specific organic components (IR), elements within the prescribed limits (AAS) of Ayurveda. The adjuvant’s effectiveness was shown by in-process standardization and showed promising pharmacological effects without any toxic effects the dose selected was 25mg to 50mg
Conclusions: The size, smoother surface and therapeutic effectiveness of the herbominerals prepared by the two methods can be attributed to the calcination steps and adjuvants. Thus, maybe dose reduction and rapid effect can be achieved.
Comparison between the Efficacy of Nigella Sativa Aqueous Extract and Its Oil on Methimazole-induced Hypothyroidism in Albino Mice
Authors: Hassan Hla Yaseen , Fadel Hiam Kamel 
Published: March 2023

Objective: This study was conducted to evaluate the impact of both aqueous extract of Nigella sativa and its oil in treating the hypothyroid induced by methimazole in female of white mice in order to determine which one of them is more effective in treating of hypothyroidism, aiming to use it as a natural treatment instead of the chemical treatments which have dangerous side effects.
Materials and Methods: The study included 40 female white mice dived into 4 groups 10 mice each one. Group 1 (control): orally administered and treated with distilled water. Group 2 (HYP): orally treated with methimazole at a dose 0.05-mg/kg/ body weight/day for 3 weeks. Group 3 (NSE): the hypothyroidism was induced as in group 2, then treated orally with aqueous Nigella sativa extract at a dose of 400mg/kg/body weight/ day for 4 weeks. Group 4 (NSO): the hypothyroidism was induced as group 2, then treated orally with Nigella sativa oil at a dose of 1 ml/kg/body weight/ day for 4 weeks.
Results: This study showed that both NSE and NSO caused a significant decreasing p<0.05 of TSH level and a significant increase of FT3 level. Also, NSO caused increasing of FT4 level, while the increase of FT4 was un-significant under NSE treatment.
Conclusions: The efficacy of NSO is higher than the NSE in treating hypothyroidism.
PENGEMBANGAN PEMBELAJARAN GERAK DASAR LOMPAT JAUH GAYA JONGKOK DENGAN PERMAINAN MERAIH SASARAN
Authors: Rosita Yuyu 
Published: March 2023

Penelitian ini bertujuan untuk menghasilkan produk berupa pengembangan model pembelajaran gerak dasar lompat jauh gaya jongkok dengan permainan meraih sasaran bola di udara pada siswa kelas V SDN Darmaga IV. Penelitian ini dilaksanakan di SDN Darmaga IV. Instrumen yang digunakan berbentuk kuesioner dan pengamatan gerak siswa untuk pengumpulan data dari evaluasi ahli dan uji coba dengan pertimbangan jumlah subjek yang relatif banyak dan diambil secara serentak dalam waktu yang singkat. Teknik analisis data yang digunakan menggunakan teknik analisis deskriptif berbentuk persentase, dengan saran dan alasan memilih jawaban responden dianalisis secara teknik analisis kualitatif. Metode penelitian yang digunakan adalah data kuantitatif dan kualitatif. Hasil uji ahli penjas dan ahli pembelajaran dalam uji coba skala kecil (N15), diperoleh hasil dengan rata-rata persentase 85% (baik) dan uji lapangan skala besar (N=43) diperoleh hasil dengan persentase 89% (sangat baik). Hasil dari pengamatan gerak pada uji coba skla kecil (N15) hasil yang diperoleh dengan rata-rata persentase 81% (Baik), pada uji coba skala besar (N43) hasil yang diperoleh dengan rata-rata persentase 84,33% (Baik). Berdasarkan hasil data yang diperoleh tersebut, dapat disimpulkan bahwa permainan hasil pengembangan pembelajaran gerak dasar lompat jauh gaya jongkok dengan permainan meraih sasaran bola di udara dapat layak digunakan pada siswa kelas V SDN Darmaga IV.
MENINGKATKAN KEAKTIFAN DAN HASIL BELAJAR SISWA PKN MENGGUNAKAN METODE PEMBERIAN TUGAS DENGAN MEDIA VIDEO PADA PEMBELAJARAN DARING DI MASA PANDEMI
Authors: Wijayanti Dyah 
Published: March 2023

Penelitian ini merupakan penelitian tindakan kelas, dan hipotesis dalam penelitian ini adalah keaktifan dan hasil belajar dapat meningkatkan dengan menggunakan metode Pemberian Tugas Dengan Media Video. Subjek yang melakukan tindakan adalah guru (peneliti) dengan guru mata pelajaran PKn sebagai (Pengamat) Hasil Penelitian menunjukkan bahwa dengan menggunakan metode Pemberian Tugas Dengan Media Video ini ternyata lebih efektif dalam proses pembelajaran, yang ditunjukkan dengan meningkatnya keaktifan dan hasil belajar siswa: 1). Penerapan pembelajaran Pemberian Tugas Dengan Media Video dapat meningkatkan keaktifan siswa dalam pelajaran PKn yaitu pada Pra Siklus 57,84%, Siklus I 67,88%, pada Siklus II 75,68% dari jumlah siswa 36 siswa. 2). Hasil belajar siswa meningkat ditunjukkan dengan peningkatan rata-rata siswa pada Pra siklus (56,6) atau 38% siswa tuntas, Siklus I rata-rata (70,85) atau 73% dan pada Siklus II rata-rata meningkat menjadi (75,29) atau 94%. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa pembelajaran Pendidikan Kewarganegaraan yang menggunakan metode pembelajaran Pemberian Tugas Dengan Media Video lebih memungkinkan untuk meningkatkan keaktifan dan hasil belajar siswa bila dibandingkan dengan pembelajaran dengan menggunakan metode ceramah.
Estrategias de eficiencia energética en un edificio privado en clima cálido subhúmedo
Authors: Palacios de Paz Andrea , Ruiz Torres Raul Pavel , Gómez Barranco Heydi , González García Eddy 
Published: March 2023

Se presenta la evaluación energética de un edificio privado denominado Clínica CREARH-ART centro regional especializado en apoyo a la reproducción humana, ubicada en la ciudad de Tuxtla Gutiérrez en el estado de Chiapas, donde se cuenta con un clima cálido subhúmedo, dicha edificio es producto de diseño del despacho de arquitectos AYB Arquitectos que no cuenta con estrategias bioclimáticas desde su concepción.
El objetivo principal fue determinar cuali-cuantitativamente el impacto de la aplicación de estrategias bioclimáticas en la clínica CREARH-ART, evaluando el factor energético para poder reducir los gastos energéticos que esta presenta. La clínica cuenta con una orientación sur poniente y de configuración compacta, las estrategias aplicadas a la clínica constan de protección solar tipo louvers en la fachada principal (la más crítica) que consta de un ventanal y se encuentra ubicada al sur y aislamiento térmico en losa de azotea específicamente un techo verde semi-intensivo. La evaluación se realizó por medio experimental y por simulación térmica en el periodo cálido.
La metodología propuesta para encontrar las estrategias se basa en el Sistema de Gestión de la Energía que consta de cinco etapas y se diseña teniendo en cuenta los requerimientos de la NC-ISO 50001: 2011. (CONUEE, n.d.) en consecuencia el diseño del experimento fue basado en la metodología PHVA de mejora continua (planificar-hacer-verificar-actuar) esta es una metodología cuali-cuantitativa ya que se realizaron visitas a la clínica para obtener datos duros sobre el funcionamiento energético del edificio esto mediante encuestas y entrevistas con los encargados de la clínica y de manera experimental por medio de monitoreo longitudinal en el periodo cálido. El monitoreo se realizó con sensores de temperatura del aire y humedad relativa, al interior de la clínica. Para los louvers en el ventanal de la fachada principal se instaló sensores en la entrada de radiación solar al interior de la clínica y para el aislamiento térmico por losa de azotea se instaló en el tercer nivel de dicha clínica. Para la simulación térmica se comparó la clínica sin las estrategias y con estrategias, el software utilizado para la simulación fue Design Builder. Los resultados demostraron que un día típico del mes de diciembre con cielo despejado la temperatura interior en primer nivel, segundo resultó 7°C por debajo de la temperatura exterior, siendo de 35°C en el exterior, y en tercer nivel resultó 6°C menor que el exterior, también se observó una disminución de la oscilación térmica en el interior. En la simulación energética resalta un ahorro del 49% de consumo energético al utilizar aire acondicionado en todas las zonas del edificio sin contar a los baños y áreas de espera entre el modelo con estrategias y el modelo sin estrategias.
جمالياتُ الانزياحِ في الضَّرُوْرَةِ الشِّعْرِيَّةِ(الحذف التركيبي) أنْمُوْذَجاً
Authors: المنصوري سامي علي , علي أحمد عبد الكاظم 
Published: March 2023

يرمي البحث إلى تطبيق مفهوم الانزياح الأسلوبي على ظواهر من الضرورة الشعرية ، على أساس الانزياح عن القاعدة التي تمس الحذف على مستوى التركيب ، وتحاول الدراسة تسويغ ورود الحذف التركيبي فنياً وجمالياً ؛ ليثبت الباحث ومن التطبيق على عينات من الظواهر أن استقلالها ضمن الضرورة الشعرية ـ عند النحويين واللغويين ـ قد أوهى من قيمتها لأدبية الأدب ؛ فالشاعر المبدع يستثمر تجليات الظاهرة الفنية ، وفاعلياتها الدلالية ، وأبعادها الجمالية ، والإيقاعية بالانزياح عن القواعد المعيارية ؛ لتشكيل لغته الشعرية ، والتأثير في المتلقي.