bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of maternal motor vehicle crashes during pregnancy with offspring’s neonatal birth outcomes
Authors: Chang Ya-Hui , Chien Yu-Wen , Chang Chiung-Hsin , Chen Ping-Ling , Lu Tsung-Hsueh , Hsu I-Lin , Li Chung-Yi 
Published: September 2023

AbstractBackgroundAdverse events in fetuses are well researched but studies on the follow-up health outcomes of infants exposed to maternal motor vehicle crashes (MVCs) during pregnancy have yielded inconsistent results. This study aimed to investigate the association of maternal exposure to MVCs during pregnancy with the risk of adverse neonatal outcomes.MethodsThis population-based cohort study used data from birth notifications in Taiwan. A total of 19 277 offspring with maternal exposure to MVCs during pregnancy and 76 015 randomly selected comparison offspring without such exposure were selected. Neonatal adverse outcomes were identified from National Health Insurance medical claims data. Conditional logistic regression was used to estimate the unadjusted and adjusted odds ratios (aORs) of neonatal adverse outcomes.ResultsOffspring exposed to maternal MVCs during pregnancy had a higher risk of birth defects (aOR, 1.21; 95% CI, 1.04–1.41) than offspring without such exposure. This positive association was sustained with exposure to an MVC during the first or second trimester. A dose–response relationship (P = 0.0023) was observed between the level of injury severity and the risk of birth defects.ConclusionsIn the early stages of pregnancy, maternal exposure to MVCs may entail a risk of birth defects in the offspring. The potential mechanisms for the associations of maternal exposure to MVCs with birth defects need further investigation.
Communicating and understanding statistical measures when quantifying the between-group difference in competing risks
Authors: Wu Hongji , Zhang Chengfeng , Hou Yawen , Chen Zheng 
Published: September 2023

Abstract
Competing risks issues are common in clinical trials and epidemiological studies for patients in follow-up who may experience a variety of possible outcomes. Under such competing risks, two hazard-based statistical methods, cause-specific hazard (CSH) and subdistribution hazard (SDH), are frequently used to assess treatment effects among groups. However, the outcomes of the CSH-based and SDH-based methods have a close connection with the proportional hazards (CSH or SDH) assumption and may have an non-intuitive interpretation. Recently, restricted mean time lost (RMTL) has been used as an alternative summary measure for analysing competing risks, due to its clinical interpretability and robustness to the proportional hazards assumption. Considering the above approaches, we summarize the differences between hazard-based and RMTL-based methods from the aspects of practical interpretation, proportional hazards model assumption and the selection of restricted time points, and propose corresponding suggestions for the analysis of between-group differences under competing risks. Moreover, an R package ‘cRMTL’ and corresponding step-by-step guidance are available to help users for applying these approaches.
Rotavirus Genotypes in the Postvaccine Era: A Systematic Review and Meta-analysis of Global, Regional, and Temporal Trends by Rotavirus Vaccine Introduction
Authors: Amin Avnika B , Cates Jordan E , Liu Zihao , Wu Joanne , Ali Iman , Rodriguez Alexia , Panjwani Junaid , Tate Jacqueline E , Lopman Benjamin A , Parashar Umesh D 
Published: September 2023

Abstract

Background
Even moderate differences in rotavirus vaccine effectiveness against nonvaccine genotypes may exert selective pressures on circulating rotaviruses. Whether this vaccine effect or natural temporal fluctuations underlie observed changes in genotype distributions is unclear.

Methods
We systematically reviewed studies reporting rotavirus genotypes from children &lt;5 years of age globally between 2005 and 2023. We compared rotavirus genotypes between vaccine-introducing and nonintroducing settings globally and by World Health Organization (WHO) region, calendar time, and time since vaccine introduction.

Results
Crude pooling of genotype data from 361 studies indicated higher G2P[4], a nonvaccine genotype, prevalence in vaccine-introducing settings, both globally and by WHO region. This difference did not emerge when examining genotypes over time in the Americas, the only region with robust longitudinal data. Relative to nonintroducing settings, G2P[4] detections were more likely in settings with recent introduction (eg, 1–2 years postintroduction adjusted odds ratio [aOR], 4.39; 95% confidence interval [CI], 2.87–6.72) but were similarly likely in settings with more time elapsed since introduction, (eg, 7 or more years aOR, 1.62; 95% CI, .49–5.37).

Conclusions
When accounting for both regional and temporal trends, there was no substantial evidence of long-term vaccine-related selective pressures on circulating genotypes. Increased prevalence of G2P[4] may be transient after rotavirus vaccine introduction.
Exit from Nuremberg to the Hague: The Malabo Protocol and the Pan-African Road to Arusha
Authors: Ba Oumar 
Published: September 2023

Abstract
In adopting the Malabo Protocol and creating the African Court of Justice and Human Rights, the African Union has established the first ever regional court with international criminal jurisdiction. This milestone signals once again, the role of African institutions in creating and developing norms in international politics. Yet, both International Relations (IR) theories and debates and official narratives of the historiography of the international legal order tend to omit the sustained contributions of African states and institutions. Echoes of the African Union (AU)’s efforts to define and codify crimes that are of concern to its constituents can be found in the African states’ interventions at the International Law Commission during the 1980s and the negotiations that lead to the creation of the International Criminal Court (ICC) in the 1990s. This article argues that beyond the critique and skepticism about the Malabo Protocol and the AU’s agenda, there is a sustained vision and trajectory that underlies African agency in norms creation and attempts to usher in an international legal order that speaks more directly and equitably to the concerns of the continent. Ultimately, I propose a genealogy of those Pan-African visions for an embedded international justice system that provides a fundamental corrective to the Nuremberg to The Hague narrative.
Nitrofurantoin: what is the evidence for current UK guidance?
Authors: Kashouris Eleanor , Joseph Amelia , Lewis Tom 
Published: September 2023

Abstract
Three days of nitrofurantoin at 100 mg twice daily is recommended as first-line treatment for uncomplicated urinary tract infection (UTI) in evidence-based guidelines across the UK. A review of international guidelines shows that the evidence base has been interpreted in very different ways. UK guidelines are unusual in promoting short (3 day) courses, and we find little direct evidence to support this. Although ‘short’ courses of antibiotics for other agents may provide optimum balance between providing effective treatment whilst reducing selective pressure driving resistance amongst colonizing microbial flora, it remains unclear that course lengths can be extrapolated to nitrofurantoin. Three days of nitrofurantoin may indeed be a useful intervention in a large group of patients. However, without supporting evidence and because clinical response should be expected to vary widely, it is unclear that establishing and promoting an antibiotic duration for UTI is the best approach to optimizing prescribing in this important area.
NKG2A discriminates natural killer cells with a suppressed phenotype in pediatric acute leukemia
Authors: Ulvmoen Aina , Greiff Victor , Bechensteen Anne G , Inngjerdingen Marit 
Published: September 2023

Abstract
Natural killer (NK) cells are important for early tumor immune surveillance. In patients with hematological cancers, NK cells are generally functional deficient and display dysregulations in their receptor repertoires. Acute leukemia is the most common cancer in children, and we here performed a comparative phenotypic profiling of NK cells from B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients to identify aberrant NK cell phenotypes. NK cell phenotypes, maturation, and function were analyzed in matched bone marrow and blood NK cells from BCP-ALL patients at diagnosis, during treatment, and at end of treatment and compared with age-matched pediatric control subjects. Expression of several markers were skewed in patients, but with large interindividual variations. Undertaking a multiparameter approach, we found that high expression levels of NKG2A was the single predominant marker distinguishing NK cells in BCP-ALL patients compared with healthy control subjects. Moreover, naïve CD57−NKG2A NK cells dominated in BCP-ALL patients at diagnosis. Further, we found dysregulated expression of the activating receptor DNAM-1 in resident bone marrow CXCR6+ NK cells. CXCR6+ NK cells lacking DNAM-1 expressed NKG2A and had a tendency for lower degranulation activity. In conclusion, high expression of NKG2A dominates NK cell phenotypes from pediatric BCP-ALL patients, indicating that NKG2A could be targeted in therapies for this patient group.
Overview of approaches to estimate real-world disease progression in lung cancer
Authors: Amorrortu Rossybelle , Garcia Melany , Zhao Yayi , El Naqa Issam , Balagurunathan Yoganand , Chen Dung-Tsa , Thieu Thanh , Schabath Matthew B , Rollison Dana E 
Published: September 2023

AbstractBackgroundRandomized clinical trials of novel treatments for solid tumors normally measure disease progression using the Response Evaluation Criteria in Solid Tumors. However, novel, scalable approaches to estimate disease progression using real-world data are needed to advance cancer outcomes research. The purpose of this narrative review is to summarize examples from the existing literature on approaches to estimate real-world disease progression and their relative strengths and limitations, using lung cancer as a case study.MethodsA narrative literature review was conducted in PubMed to identify articles that used approaches to estimate real-world disease progression in lung cancer patients. Data abstracted included data source, approach used to estimate real-world progression, and comparison to a selected gold standard (if applicable).ResultsA total of 40 articles were identified from 2008 to 2022. Five approaches to estimate real-world disease progression were identified including manual abstraction of medical records, natural language processing of clinical notes and/or radiology reports, treatment-based algorithms, changes in tumor volume, and delta radiomics–based approaches. The accuracy of these progression approaches were assessed using different methods, including correlations between real-world endpoints and overall survival for manual abstraction (Spearman rank ρ = 0.61-0.84) and area under the curve for natural language processing approaches (area under the curve = 0.86-0.96).ConclusionsReal-world disease progression has been measured in several observational studies of lung cancer. However, comparing the accuracy of methods across studies is challenging, in part, because of the lack of a gold standard and the different methods used to evaluate accuracy. Concerted efforts are needed to define a gold standard and quality metrics for real-world data.
Large-scale identification of novel transcriptional regulators of the aliphatic glucosinolate pathway in Arabidopsis
Authors: Chen Lin , Zeng Qi , Zhang Jiahao , Li Chao , Bai Xue , Sun Fengli , Kliebenstein Daniel J , Li Baohua 
Published: September 2023

Abstract
Aliphatic glucosinolates are a large group of plant secondary metabolites characteristic of Brassicaceae, including the model plant Arabidopsis. The diverse and complex degradation products of aliphatic glucosinolates contribute to plant responses to herbivory, pathogen attack, and environmental stresses. Most of the biosynthesis genes in the aliphatic glucosinolate pathway have been cloned in Arabidopsis, and the research focus has recently shifted to the regulatory mechanisms controlling aliphatic glucosinolate accumulation. Up till now, more than 40 transcriptional regulators have been identified as regulating the aliphatic glucosinolate pathway, but many more novel regulators likely remain to be discovered based on research evidence over the past decade. In the current study, we took a systemic approach to functionally test 155 candidate transcription factors in Arabidopsis identified by yeast one-hybrid assay, and successfully validated at least 30 novel regulators that could significantly influence the accumulation of aliphatic glucosinolates in our experimental set-up. We also showed that the regulators of the aliphatic glucosinolate pathway have balanced positive and negative effects, and glucosinolate metabolism and plant development can be coordinated. Our work is the largest scale effort so far to validate transcriptional regulators of a plant secondary metabolism pathway, and provides new insights into how the highly diverse plant secondary metabolism is regulated at the transcriptional level.
Narcissism Is Not Associated With Success in U.S. Army Soldier Training
Authors: Newman Jill C , Malek Angela M , Hibbeln Joseph R , Pregulman Marcie , Burbelo Gregory A , Turner Travis H , Marriott Bernadette P 
Published: September 2023

ABSTRACT

Introduction
Narcissism has been studied for its role in leadership using various versions of the Narcissistic Personality Inventory (NPI). Narcissism is described as having a “dark and negative” side as well as a “positive or bright” side. The bright side of narcissism, in particular, has been studied for its role in leadership. In studies among military personnel in Finland and Hungary, the NPI has been associated with positive leadership traits. We assessed if measures of narcissistic personality were predictive of entrance to and graduation from the Army Ranger Course among United States (U.S.) Army personnel.

Materials and Methods
We included the NPI as one of the measures in the Ranger Resilience and Improved Performance on Phospholipid-bound Omega-3’s (RRIPP-3) study. RRIPP-3 was a double-blind, placebo-controlled dietary supplement intervention trial at Fort Benning, GA, that enrolled 555 officers when they entered the U.S. Army Infantry Basic Officer Leadership Course (IBOLC) with the intention to complete the U.S. Ranger School. RRIPP-3 volunteer participants consumed eight dietary supplements daily containing 2.3 g of omega-3 (krill oil) or macadamia nut oil (control) over a 20-week period. Blood spot samples were collected to monitor intake compliance. Cognitive functioning, resilience, and mood were assessed at approximately 14 and 16 weeks. Dietary intake was also assessed. The 40-item, forced-choice NPI was included to assess if three factors of narcissism: Leadership/Authority, Grandiose/Exhibitionism, and Entitlement/Exploitativeness measures of narcissistic personality were associated with entrance to and graduation from the Army Ranger Course.

Results
Of the 555 soldiers enrolled in RRIPP-3, there were no statistically significant differences in the total NPI scores comparing U.S. Army IBOLC officers who enrolled (n = 225) versus did not enroll (n = 330, p = .649) or graduated (n = 95; versus did not graduate [n = 460, p = .451]) from the Ranger Course. None of the three-factor NPI subscales differed statistically comparing either enrollment in (p = .442, .510, and .589, respectively) or graduation from the Ranger Course (p = .814, .508, and .813, respectively).

Conclusions
Although narcissism has been positively associated with military trainee success in other countries, we did not find an association between narcissism and trainee success among U.S. Army trainees, and accordingly the level of narcissism did not predict trainee success or failure.
Embracing Leadership: How Junior Medical Officers Shape the Future
Authors: Redondo Jose , Robbins Rachel 
Published: September 2023

ABSTRACT
Transitioning from medical residency to an operational role challenges junior medical officers as their leadership skills are put to the test. In the multifaceted role of Military Medical Corps Officers, patient care remains paramount, and effective leadership hinges on core values. From clinical competence and mentorship to modeling behavior and fostering adaptability, this article underscores the importance of leadership development for junior officers as they transition from the training centers into the operational environment. Effective junior officer leaders become force multipliers, empowering their teams and cultivating future leaders to uphold the values essential to mission success.
Analysing mixed modes of the four solar-like oscillating subgiant stars
Authors: Çelik Orhan Z , Yıldız M , Örtel S 
Published: September 2023

ABSTRACT
The observation of an unprecedented number of solar-like oscillating subgiant (SG) stars by the Kepler and TESS missions is crucial for the asteroseismic characterization of these stars, stellar population studies, and the study of stellar evolution theories. Owing to these missions, the fundamental parameters of the solar-like oscillating stars are precisely calculated from the evolution codes using the observed oscillation frequencies. Herein, we considered four solar-like oscillating SG stars. We obtained the fundamental parameters of the SG stars by constructing interior models using asteroseismic and non-asteroseismic observed parameters. The interior models of the four SG stars are constructed using the Modules for Experiments in Stellar Astrophysics code to effectively determine the fundamental properties. Using this method, the four solar-like oscillating SG stars are found to have masses and radii within the ranges of 1.16–1.75 M⊙ and 2.26–3.17 R⊙, respectively. The estimation accuracy of the typical asteroseismic radius, mass, and age is increased by fitting the observed and model reference frequencies. The typical uncertainties of the mass and radius are 3–4 ${{\ \rm per\ cent}}$ and 1–2 ${{\ \rm per\ cent}}$, respectively. Furthermore, the observed l = 1 frequencies, which showed a mixed mode for the first time, were also fitted to the models. Information regarding the gravity and density of the helium core was obtained by examining the mixed modes. Moreover, new asteroseismic methods for determining the age of SG stars are developed for the first time in this study.
Modelling variable linear polarization produced by Co-rotating Interaction Regions (CIRs) across optical recombination lines of Wolf–Rayet stars
Authors: Ignace R , Bjorkman J E , Chené A-N , Erba C , Fabiani L , Moffat A F J , Sincennes R , St-Louis N 
Published: September 2023

ABSTRACT
Massive star winds are structured both stochastically (‘clumps’) and often coherently (Co-rotation Interaction Regions, or CIRs). Evidence for CIRs threading the winds of Wolf–Rayet (WR) stars arises from multiple diagnostics including linear polarimetry. Some observations indicate changes in polarization position angle across optical recombination emission lines from a WR star wind but limited to blueshifted Doppler velocities. We explore a model involving a spherical wind with a single conical CIR stemming from a rotating star as qualitative proof-of-concept. To obtain a realistic distribution of limb polarization and limb darkening across the pseudo-photosphere formed in the optically thick wind of a WR star, we used Monte Carlo radiative transfer (MCRT). Results are shown for a parameter study. For line properties similar to WR 6 (EZ CMa; HD 50896), combining the MCRT results, a simple model for the CIR, and the Sobolev approximation for the line formation, we were able to reproduce variations in both polarization amplitude and position angle commensurate with observations. Characterizing CIRs in WR winds has added importance for providing stellar rotation periods since the vsin i values are unobtainable because the pseudo-photosphere forms in the wind itself.
Epigenetic reprogramming of a distal developmental enhancer cluster drivesSOX2overexpression in breast and lung adenocarcinoma
Authors: Abatti Luis E , Lado-Fernández Patricia , Huynh Linh , Collado Manuel , Hoffman Michael M , Mitchell Jennifer A 
Published: September 2023

AbstractEnhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal development that is aberrantly activated in breast and lung adenocarcinoma. Deletion of the SRR124–134 cluster disrupts expression of the SOX2 oncogene, dysregulates genome-wide transcription and chromatin accessibility and reduces the ability of cancer cells to form colonies in vitro. Analysis of primary tumors reveals a correlation between chromatin accessibility at this cluster and SOX2 overexpression in breast and lung cancer patients. We demonstrate that FOXA1 is an activator and NFIB is a repressor of SRR124–134 activity and SOX2 transcription in cancer cells, revealing a co-opting of the regulatory mechanisms involved in early development. Notably, we show that the conserved SRR124 and SRR134 regions are essential during mouse development, where homozygous deletion results in the lethal failure of esophageal–tracheal separation. These findings provide insights into how developmental enhancers can be reprogrammed during tumorigenesis and underscore the importance of understanding enhancer dynamics during development and disease.
Quantum biological insights into CRISPR-Cas9 sgRNA efficiency from explainable-AI driven feature engineering
Authors: Noshay Jaclyn M , Walker Tyler , Alexander William G , Klingeman Dawn M , Romero Jonathon , Walker Angelica M , Prates Erica , Eckert Carrie , Irle Stephan , Kainer David , Jacobson Daniel A 
Published: September 2023

Abstract
CRISPR-Cas9 tools have transformed genetic manipulation capabilities in the laboratory. Empirical rules-of-thumb have been developed for only a narrow range of model organisms, and mechanistic underpinnings for sgRNA efficiency remain poorly understood. This work establishes a novel feature set and new public resource, produced with quantum chemical tensors, for interpreting and predicting sgRNA efficiency. Feature engineering for sgRNA efficiency is performed using an explainable-artificial intelligence model: iterative Random Forest (iRF). By encoding quantitative attributes of position-specific sequences for Escherichia coli sgRNAs, we identify important traits for sgRNA design in bacterial species. Additionally, we show that expanding positional encoding to quantum descriptors of base-pair, dimer, trimer, and tetramer sequences captures intricate interactions in local and neighboring nucleotides of the target DNA. These features highlight variation in CRISPR-Cas9 sgRNA dynamics between E. coli and H. sapiens genomes. These novel encodings of sgRNAs enhance our understanding of the elaborate quantum biological processes involved in CRISPR-Cas9 machinery.