bluuebunny/crossref_metadata_2025_split huggingface dataset:
Degenerate Cauchy–Goursat problem for 2‐D steady isentropic Euler system with van der Waals gas
Authors: Srivastava H. , Zafar M. 
Published: September 2023

AbstractThis study concerns with the existence–uniqueness of local classical sonic‐supersonic solution to a degenerate Cauchy–Goursat problem that arises in transonic phenomena. The flow is governed by 2‐D steady isentropic Euler system with a polytropic van der Waals gas. The idea of characteristic decomposition has been used to convert the Euler system into a new system involving the angle variables . To overcome the parabolic degeneracy caused at the sonic curve, the partial hodograph transformation and a variety of dependent–independent variables have been introduced to transform the nonlinear system into a linear one with explicit singularity–regularity structure. The uniform convergence of the sequences has been discussed by employing the mathematical induction. Eventually, the inversion of the solution from partial hodograph plane to the original plane has been established.
Preparing students to address the social determinants of health in integrated care settings
Authors: McGinley Jacqueline M. , Pauling Erin E. , Rouhana Nicole , Podolak Christine E. , Cowen Nannette , Hennig Kelsey , Shipe Stacey L. , Young Sarah R. , Rattinger Gail B. 
Published: September 2023

AbstractBackgroundHealth professionals are increasingly being called to address the social determinants of health (SDOH) and, to do so effectively, often requires an integrated approach to care. As a result, accreditation standards across multiple professions have emphasised the importance of interprofessional education (IPE).ApproachThis paper describes large‐scale, community‐engaged learning that is required annually of students from nursing, pharmacy, public health, and social work. Through a series of asynchronous and synchronous activities that are informed by the Interprofessional Education Collaborative core competencies, students are trained to be SDOH change makers who can readily adopt integrated care service delivery frameworks into their future practice.EvaluationApproximately 1000 students have participated in this event since the University launched its IPE curriculum in 2017. Student consistently report achievement of the course learning objectives, with 91% of students reporting that the learning activities enhanced their understanding of their professional roles/responsibilities in regards to addressing poverty and food insecurity.ImplicationsTwo key lessons learned from these efforts are described, including the benefits of a trauma‐informed pedagogical approach and special considerations for large‐scale learning.
The role of centromeric repeats and transcripts in kinetochore assembly and function
Authors: Ramakrishnan Chandra Jothipriya , Kalidass Manikandan , Demidov Dmitri , Dabravolski Siarhei A. , Lermontova Inna 
Published: September 2023

SUMMARYCentromeres are the chromosomal domains, where the kinetochore protein complex is formed, mediating proper segregation of chromosomes during cell division. Although the function of centromeres has remained conserved during evolution, centromeric DNA is highly variable, even in closely related species. In addition, the composition of the kinetochore complexes varies among organisms. Therefore, it is assumed that the centromeric position is determined epigenetically, and the centromeric histone H3 (CENH3) serves as an epigenetic marker. The loading of CENH3 onto centromeres depends on centromere‐licensing factors, chaperones, and transcription of centromeric repeats. Several proteins that regulate CENH3 loading and kinetochore assembly interact with the centromeric transcripts and DNA in a sequence‐independent manner. However, the functional aspects of these interactions are not fully understood. This review discusses the variability of centromeric sequences in different organisms and the regulation of their transcription through the RNA Pol II and RNAi machinery. The data suggest that the interaction of proteins involved in CENH3 loading and kinetochore assembly with centromeric DNA and transcripts plays a role in centromere, and possibly neocentromere, formation in a sequence‐independent manner.
Cytologic, histopathologic, and immunohistochemical features of keloidal fibroma in a dog
Authors: Palić Jelena , Saey Veronique , van der Lugt Jaco , Baumgärtner Wolfgang , Hülskötter Kirsten 
Published: September 2023

AbstractA five‐year‐old male English Bulldog was presented with a firm, well‐circumscribed, 1 cm in diameter cutaneous mass on the left flank. Fine‐needle aspiration (FNA) biopsy samples were collected for cytologic analysis. Cytology revealed a highly cellular sample consisting of spindle cells, numerous bundles of thick, glassy eosinophilic material (hyalinized collagen), and inflammatory cells. Spindle cells showed moderate anisocytosis and anisokaryosis, had oval nuclei with coarsely stippled chromatin, 1–3 prominent round nucleoli, and moderate amounts of wispy cytoplasm. Cells were occasionally associated with an eosinophilic extracellular matrix. Binucleated and trinucleated spindle cells were often noted. Low numbers of macrophages, small lymphocytes, and individual well‐granulated mast cells were also present. The lesion was excised and submitted for histopathologic examination, revealing a well‐delineated, nonencapsulated mass composed of hyalinized collagen fibers separated by spindle‐shaped mesenchymal cells in the deep dermis and subcutis. Mild anisocytosis and anisokaryosis and less than one mitosis per 10 × high power fields were present. Excision of the mass was complete. The findings were consistent with a keloidal fibroma, a rare benign variant of fibroma. Neoplastic cells showed positive immunoreactivity for vimentin, and a small‐to‐moderate number of tumor cells showed positive immunoreactivity for α‐smooth muscle actin. This is the first cytologic description of a keloidal fibroma correlated with histopathologic findings and immunolabeling. In cases where keloidal neoplasia is suspected, and since moderate cellular atypia can be present on cytologic examination even in cases of keloidal fibroma, histopathologic examination is necessary to differentiate between keloidal fibroma and keloidal fibrosarcoma.
ROWAN WILLIAMS ON ATTENTION AND MEMORY IN THE SPIRITUAL LIFE
Authors: Watts Fraser 
Published: September 2023

AbstractIn a series of recent articles, including his Boyle Lecture, Rowan Williams has developed a theology of the role of intelligence and attention in spiritual life. There is a sense in which all intelligence is spiritual activity. Current approaches to intelligence are often mechanistic, but intelligence in spiritual life needs to be understood in a more embodied and organic way. Attention is often thought of as a matter of choosing which already‐formed objects to focus on. That overlooks the fact that sensory information is often confusing and ambiguous, and neglects how habits of attention make the world appear more atomized than it really is. If we can learn restraint in how we impose order upon the world around us in attending to it, there is an opportunity to encounter the divine Spirit which is the source of all that we experience. That leads to a more participatory, less objectifying, way of engaging with the world.
Positivity and nonstandard graded Betti numbers
Authors: Brown Michael K. , Erman Daniel 
Published: September 2023

AbstractA foundational principle in the study of modules over standard graded polynomial rings is that geometric positivity conditions imply vanishing of Betti numbers. The main goal of this paper is to determine the extent to which this principle extends to the nonstandard ‐graded case. In this setting, the classical arguments break down, and the results become much more nuanced. We introduce a new notion of Castelnuovo–Mumford regularity and employ exterior algebra techniques to control the shapes of nonstandard ‐graded minimal free resolutions. Our main result reveals a unique feature in the nonstandard ‐graded case: the possible degrees of the syzygies of a graded module in this setting are controlled not only by its regularity, but also by its depth. As an application of our main result, we show that given a simplicial projective toric variety and a module over its coordinate ring, the multigraded Betti numbers of are contained in a particular polytope when satisfies an appropriate positivity condition.
Synthesis and Antiproliferative Activity of New Copper, Cobalt, and Zinc Complexes with Abiraterone Acetate
Authors: Antonenko T. A. , Gracheva Yu. A. , Zazdravnykh A. V. , Mazur D. M. , Shpakovsky D. B. , Lyssenko K. A. , Milaeva E. R. 
Published: September 2023

Abstract
New complexes CuCl2[AbAc]2 (I), CoCl2[AbAc]2 (II), and ZnCl2[AbAc]2 (III) with abiraterone acetate (AbAc) are synthesized. The molecular structure of complex II is determined by X-ray diffraction (XRD) (CIF file CCDC no. 2252346). The cobalt atom coordinates with abiraterone acetate due to the N‑donor pyridine atom. The model processes of hydrolysis of the compounds in acidic and neutral media and their ability to interact with the superoxide radical anion generated in the xanthine–xanthine oxidase enzymatic system are studied. A high activity of complexes I and II is found. The MTT test shows that the antiproliferative activity of compounds I–III against the HCT-116, MCF-7, A-549, and WI-38 cells is comparable with the activity of cisplatin and exceeds that of the initial AbAc for the PC-3 cell line. Complex II also induces cell cycle arrest in the G0/G1 phase of RNA protein synthesis.
Making health insurance responsive to citizens: the management of members’ complaints by mutual health organisations in Kinshasa, Democratic Republic of Congo
Authors: Ngo Bebe Dosithee , Kwilu Fulbert Nappa , Mavila Arlette , Mafuta Eric Musalu , Mangalu José Mobhe , Jessani Nasreen S , Criel Bart 
Published: September 2023

IntroductionIn moving towards universal health coverage, a number of low-income and middle-income countries have adopted community-based health insurance (CBHI) as a means to reduce both the inequity in healthcare access and the burden of catastrophic health expenditures linked to user fees. However, organisations managing CBHIs face many challenges, including a poor relationship with their members. In the Democratic Republic of the Congo, CBHI schemes are managed by mutual health organisations (MHOs) and are in the process of enhancing their accountability and responsiveness to members’ needs and expectations. This study assessed how MHOs have managed member complaints and their performance in grievance redressal.MethodsUsing a sequential mixed-methods approach, we drew insights from four types of sources: review of approximately 50 relevant documents, 25 in-depth interviews (IDIs) with CBHI managers, 9 IDIs with health facility managers, 1063 surveys of MHO members and 15 focus group discussions (FGDs) comprising an additional 153 MHO members. MHO members in this study belonged to three different MHOs (Lisanga, La Borne and Mutuelle de santé des Enseignants de l’Enseignement Primaire, Secondaire et Professionnel) in the capital, Kinshasa.ResultsThe document review showed that there were no clear administrative processes for the implementation of the grievance redressal arrangement measures resulting in low member awareness of these measures. These results were confirmed by the IDIs. Of 1044 members surveyed, only 240 (23%) were aware of the complaint measures, and 201 (84%) of these declared they had used the measures at some point in time, 181/201 (90%) users who had used the measures declared being satisfied with the response provided. The FGDs confirmed that most members lack knowledge on the grievance redressal procedures, but those who were aware had made use of them and were often satisfied with the response provided.ConclusionMHOs should urgently improve communication with their members on the range of redressal measures put in place to address grievances. Attention should be given to properly monitor existing arrangements, and possibly adapt them with well-documented and communicated standard operating procedures.
Trends of breastfeeding indicators in Brazil from 1996 to 2019 and the gaps to achieve the WHO/UNICEF 2030 targets
Authors: Boccolini Cristiano Siqueira , Lacerda Elisa Maria de Aquino , Bertoni Neilane , Oliveira Natália , Alves-Santos Nadya Helena , Farias Dayana Rodrigues , Crispim Sandra Patricia , Carneiro Leticia Barroso Vertulli , Schincaglia Raquel Machado , Giugliani Elsa Regina Justo , Castro Inês Rugani Ribeiro de , Kac Gilberto 
Published: September 2023

BackgroundThe comprehension of breastfeeding patterns and trends through comparable indicators is essential to plan and implement public health policies.ObjectiveTo evaluate the trends of breastfeeding indicators in Brazil from 1996 to 2019 and estimate the gap to achieve the WHO/UNICEF 2030 targets in children under 5 years.MethodsMicrodata from two National Surveys on Demography and Health of Women and Children (PNDS-1996 and PNDS-2006) and the Brazilian National Survey on Child Nutrition-2019 were used. The indicators of early initiation of breastfeeding (EIBF), exclusive breastfeeding of infants 0–5 months of age (EBF<6 mo), continued breastfeeding at 1 year of age (CBF1yr) and CBF at 2 years of age (CBF2yr) were analysed using prevalence and 95% CI. The average annual variation and years to achieve the WHO/UNICEF 2030 targets were calculated for Brazil and the macroregions. Statistical analyses considered the survey’s complex sample design for each database.ResultsEIBF increased from 36.3% (95% CI 33.6% to 39.0%) in 1996 to 60.9% (95% CI 56.5% to 65.3%) in 2006 (statistically significant) and 62.5% (95% CI 58.3% to 66.6%) in 2019. EBF<6 mo increased from 26.9% (95% CI 21.3% to 31.9%) in 1996 to 39.0% (95% CI 31.0% to 47.1%) in 2006 and 45.8% (95% CI 40.9% to 50.7%) in 2019 (significant increases for 1996–2019 for Brazil, Northeast and Midwest regions). CBF1yr rose from 36.6% (95% CI 30.8% to 42.4%) in 1996 to 48.7% (95% CI 38.3% to 59.0%) in 2006, and 52.1% (95% CI 45.4% to 58.9%) in 2019. CBF2yr increased from 24.7% (95% CI 19.5% to 29.9%) in 1996 to 24.6% (95% CI 15.7% to 33.5%) in 2006 and 35.5% (95% CI 30.4% to 40.6%) in 2019 (significant increase for 1996–2019). The South and Southeast regions need to double the 2019 prevalence to reach the target for the CBF1yr and CBF2yr; the Northeast and North need to increase 60% the current prevalence for the indicator of EBF<6 mo.ConclusionA substantial improvement in breastfeeding indicators occurred in Brazil from 1996 to 2019, although at an insufficient rate to achieve the WHO/UNICEF 2030 targets.
Governance for injury care systems in Ghana, South Africa and Rwanda: development and pilot testing of an assessment tool
Authors: Odland Maria Lisa , Abdul-Latif Abdul-Malik , Ignatowicz Agnieszka , Bekele Abebe , Chu Kathryn , Howard Anthony , Tabiri Stephen , Byiringiro Jean Claude , Davies Justine 
Published: September 2023

ObjectivesThis study aims to evaluate health systems governance for injury care in three sub-Saharan countries from policymakers’ and injury care providers’ perspectives.SettingGhana, Rwanda and South Africa.DesignBased on Siddiqiet al’s framework for governance, we developed an online assessment tool for health system governance for injury with 37 questions covering health policy and implementation under 10 overarching principles of strategic vision, participation and consensus orientation, rule of law, transparency, responsiveness of institutions, equity, effectiveness or efficiency, accountability, ethics and intelligence and information. A literature review was also done to support the scoring. We derived scores using two methods—investigator scores and respondent scores.ParticipantsThe tool was sent out to purposively selected stakeholders, including policymakers and injury care providers in Ghana, Rwanda and South Africa. Data were collected between October 2020 and February 2021.Primary and secondary outcomesInvestigator-weighted and respondent percentage scores for health system governance for injury care. This was calculated for each country in total and per principle.ResultsRwanda had the highest overall investigator-weighted percentage score (70%), followed by South Africa (59%). Ghana had the lowest overall investigator score (48%). The overall results were similar for the respondent scores. Some areas, such as participation and consensus, scored high in all three countries, while other areas, such as transparency, scored very low.ConclusionIn this multicountry governance survey, we provide insight into and evaluation of health system governance for trauma in three low- and middle-income countries (LMICs) in sub-Saharan Africa. It highlights areas of improvement that need to be prioritised, such as transparency, to meet the high burden of trauma and injuries in LMICs.
Predicting residual neoplasia after a non-curative gastric ESD: validation and modification of the eCura system in the Western setting: the W-eCura score
Authors: Morais Rui , Libanio Diogo , Dinis Ribeiro Mario , Ferreira Aníbal , Barreiro Pedro , Bourke Michael J , Gupta Sunil , Amaro Pedro , Küttner Magalhães Ricardo , Cecinato Paolo , Boal Carvalho Pedro , Pinho Rolando , Rodríguez de Santiago Enrique , Sferrazza Sandro , Lemmers Arnaud , Figueiredo Mariana , Pioche Marhieu , Gallego Francisco , Albéniz Eduardo , Ramos Zabala Felipe , Uchima Hugo , Berr Frieder , Wagner Andrej , Marques Margarida , Pimentel-Nunes Pedro , Gonçalves Margarida , Mascarenhas André , Soares Elisa Gravito , Xavier Sofia , Faria-Ramos Isabel , Sousa-Pinto Bernardo , Gullo Irene , Carneiro Fatima , Macedo Guilherme , Santos-Antunes João 
Published: September 2023

ObjectiveTo evaluate the risk factors for lymph node metastasis (LNM) after a non-curative (NC) gastric endoscopic submucosal dissection (ESD) and to validate and eventually refine the eCura scoring system in the Western setting. Also, to assess the rate and risk factors for parietal residual disease.DesignRetrospective multicentre multinational study of prospectively collected registries from 19 Western centres. Patients who had been submitted to surgery or had at least one follow-up endoscopy were included. The eCura system was applied to assess its accuracy in the Western setting, and a modified version was created according to the results (W-eCura score). The discriminative capacities of the eCura and W-eCura scores to predict LNM were assessed and compared.ResultsA total of 314 NC gastric ESDs were analysed (72% high-risk resection (HRR); 28% local-risk resection). Among HRR patients submitted to surgery, 25% had parietal disease and 15% had LNM in the surgical specimen. The risk of LNM was significantly different across the eCura groups (areas under the receiver operating characteristic curve (AUC-ROC) of 0.900 (95% CI 0.852 to 0.949)). The AUC-ROC of the W-eCura for LNM (0.916, 95% CI 0.870 to 0.961; p=0.012) was significantly higher compared with the original eCura. Positive vertical margin, lymphatic invasion and younger age were associated with a higher risk of parietal residual lesion in the surgical specimen.ConclusionThe eCura scoring system may be applied in Western countries to stratify the risk of LNM after a gastric HRR. A new score is proposed that may further decrease the number of unnecessary surgeries.
Beta-blockers and renin-angiotensin system inhibitors for Takotsubo syndrome recurrence: a network meta-analysis
Authors: Santoro Francesco , Sharkey Scott , Citro Rodolfo , Miura Tetsuji , Arcari Luca , Urbano-Moral Jose Angel , Stiermaier Thomas , Nuñez-Gil Ivan Javier , Silverio Angelo , Di Nunno Nicola , Ragnatela Ilaria , Cetera Rosa , Nishida Junichi , Eitel Ingo , Brunetti Natale Daniele 
Published: September 2023

IntroductionTakotsubo syndrome (TTS) is an acute heart failure syndrome, featured by transient left ventricular systolic dysfunction. Recurrences of TTS are not infrequent and there is no standard preventive therapy. The aim of this study was to evaluate in a network meta-analysis if beta-blockers (BB) and ACE inhibitors/angiotensin receptor blockers (ACEi/ARBs), in combination or not, can effectively prevent TTS recurrences.MethodsWe performed a systematic network meta-analysis, using MEDLINE/EMBASE and the Cochrane Central Register of Controlled Trials for clinical studies published between January 2010 and September 2022. We considered all those studies including patients receiving medical therapy with BB, ACEi/ARBs. The primary outcome was TTS recurrence.ResultsWe identified 6 clinical studies encompassing a total of 3407 patients with TTS. At 40±10 months follow-up, TTS recurrence was reported in 160 (4.7%) out of 3407 patients. Mean age was 69.8±2 years and 394 patients (11.5%) out of 3407 were male. There were no differences in terms of TTS recurrence when comparing ACEi/ARBs versus control (OR 0.83; 95% CI 0.47 to 1.47, p=0.52); BB versus control (OR 1.01; 95% CI 0.63 to 1.61, p=0.96) and ACEi/ARBs versus BB (OR 0.88; 95% CI 0.51 to 1.53, p=0.65).Combination of BB and ACEi/ARBs was also not effective in reducing the risk of recurrence versus control (OR 0.91; 95% CI 0.58 to 1.43, p=0.68) vs ACEi/ARBs (OR 0.79; 95% CI 0.46 to 1.34, p=0.38)) and vs BB (OR 0.77; 95% CI 0.49 to 1.21, p=0.26).ConclusionsOur study did not find sufficient statistical evidence regarding combination therapy with BB and ACEi/ARBs in reduction of TTS recurrence.
Using the NEISS database to understand pressure cooker related injuries in the USA
Authors: Shields Wendy , Dong Yanan , Jager Leah , Shiang Evelyn , Frattaroli Shannon , Omaki Elise 
Published: September 2023

ObjectiveTo determine the incidence of pressure cooker related injuries in US hospital emergency departments. To quantify injury patterns associated with pressure cookers and inform prevention recommendation messaging.MethodsThe National Electronic Injury Surveillance System (NEISS) was queried to identify injuries associated with pressure cookers between 1 January 2003 and 31 December 2019. Case narratives were reviewed to identify precipitating or contributing factors of pressure cooker related injuries. Negative binomial regression was employed to test for trends over time.ResultsThe NEISS query identified 759 actual pressure cooker injuries between 2003 and 2019, yielding a national estimate of 28 337 (95% CI 24 588 to 32,086) injuries treated in US emergency departments, 1667 cases annually. Analysis of case narratives resulted in the identification of four predominant precipitating or contributing factors to injury: burning agent, struck by product, injured while opening and other.ConclusionNEISS is a valuable tool for determining injury incidence and understanding common injury patterns associated with specific products. Consumers and manufacturers of pressure cookers can develop safety strategies targeted at preventing the product’s main injury risks.