bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of fracture level on the residual fracture gap during tibial intramedullary nailing for tibial shaft fractures
Authors: Albayrak Kutalmis , Misir Abdulhamit , Alpay Yakup , Buyuk Abdul Fettah , Akpinar Evren , Gursu Sukru Sarper 
Published: April 2023

Abstract
Background
The development of fracture gap during intramedullary nailing in tibial fractures is associated with poor fracture fragment contact and increased time to union and complications. This study aimed to evaluate the effect of the fracture level in the development of fracture gap and the effect of the fracture gap on pain, radiologic and functional outcomes, and complication rate.
Methods
A total of 45 patients who underwent reamed intramedullary nailing due to closed transverse or short oblique tibial shaft fractures were divided into the proximal fracture group and distal fracture group. The correlations between visual analog scale (VAS) score, modified radiograph union score for tibias (RUST), and postoperative 1-year lower extremity functional scale scores, fracture level, gap amount, and time to union were evaluated.
Results
The mean fracture gap amounts in the immediate postoperative anteroposterior and lateral radiographs were 5.6 ± 1.7 and 6.0 ± 1.7 mm in proximal fractures and 0.3 ± 2.4 mm and 0.4 ± 2.3 mm in distal fractures, respectively (p < 0.001 and p < 0.001, respectively). The mean time to union was 21.9 ± 2.9 weeks in the proximal fracture group and 16.7 ± 2.4 weeks in the distal fracture group (p < 0.000). The fracture gap amount significantly correlated with the level of fracture (r = 0.811, p < 0.001).
Conclusion
Tibial shaft fractures proximal to the isthmus level tend to develop significantly larger fracture gap than distal fractures. It is associated with increased time to union and radiographic union scores as well as slightly higher complication and reoperation rates.
Level of Evidence Level III, prognostic
MapReduce-enhanced Fuzzy K-Least Medians for Qualitative Clustering of Document Big Data
Authors: Sardar Tanvir Habib , Ansari Zahid Ahmed , Theerthagiri Prasannavenkatesan , Karthikeyan P. 
Published: April 2023

Abstract
Researchers design MapReduce-enhanced versions of traditional clustering algorithms to obtain the time performance benefit in big data clustering. However, the current literature shows that only a handful of partitioning clustering algorithms are enhanced using the MapReduce model. This work proposes a MapReduce-enhanced design of the Fuzzy K-Least Medians algorithm (MRFK-LstMdns) and its two novel variations. The purpose is to determine the best-performing MapReduce-enhanced partitioning clustering algorithms, among the proposed and existing ones, in terms of time performance and cluster quality. The work first preprocesses different sized self crawled document datasets. Then an optimal noise removal process is employed to make the dataset optimally noise free. The proposed MRFK-LstMdns and its two novel variations are designed using three MapReduce job chaining. Each of the jobs performs the staged and suitable algorithmic parts. The time performance and cluster quality of the proposed algorithms are compared against the existing MapReduce-enhanced partitioning algorithms. Although the proposed algorithm's time complexity is higher than the existing algorithms, the suitable chained MapReduce job design of the proposed algorithms makes them consume existing algorithms like execution time. A majority voting technique using seven cluster quality measures shows that the MRFK-LstMdns generates better quality clusters than existing algorithms.
Pathophysiological changes in incentive processing in episodic migraine
Authors: Li Yansong , Chen Guoliang , Liu Cuihong , Ding Weiyan , Wang Zixiang , Derrington Edmund , Zhang Bing 
Published: April 2023

Abstract
Background Multiple lines of research suggests that dysregulation in the dopaminergic system may contribute to migraine pain. However, it is only in recent years that researchers have begun to investigate this by exploring how the system is dysregulated during incentive processing in migraineurs. Still little is known about the pathophysiological changes in incentive processing along the temporal scale in migraineurs. Therefore, the present study examined migraine-related changes in neural processing implicated in incentive anticipation and its delivery.Methods A total of 19 episodic migraine (EM) patients (mean age = 31.95 ± 1.42, 17 females) and 19 healthy controls (HCs) (mean age = 30.16 ± 0.98, 16 females) underwent a monetary incentive delay (MID) task, while event-related potentials (ERPs) were recorded in their brains.Results Electrophysiologically, during the incentive anticipation phase, both Cue-N2 and Cue-P3 amplitudes were of higher magnitude for the reward-anticipation and punishment-anticipation cues compared to the control cue across both groups. This indicates no significant differences in neural activity supporting incentive/no incentive cue evaluation between groups. During the outcome phase, the amplitude of the FRN, an ERP component related to performance evaluation, was significantly larger for punishing feedback than rewarding feedback across both groups. However, the Feedback-P3 amplitude, an ERP component related to attentional processing of motivational value of outcome feedback, was significantly larger for rewarding feedback than punishing feedback in HCs, but not in EM patients. Moreover, a negative correlation was observed between the Feedback-P3 amplitude difference for rewarding minus punishing feedback and subjective pain intensity measured by the VAS in EM patients. Finally, the amplitude of the Feedback-LPP, an ERP component related to attentional processing of the affective value of outcome feedback, was significantly larger for punishing feedback than rewarding feedback only in HCs, but not in EM patients.Conclusions Our findings suggest that pathophysiological changes in incentive processing may act as a core mechanism underlying migraine pathophysiology. This study may also provide sensitive and reliable biomarkers for evaluating the efficacy of migraine therapeutics.
A web-based prediction model for early death in patients with metastatic Triple-Negative Breast Cancer: a SEER database analysis
Authors: Pan Wen-kai , Ren Si-yan , Zhu Liao-xiang , Lin Bao-chai 
Published: April 2023

Abstract
Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the absence of expression of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER-2). This subtype of breast cancer is known for its high aggressiveness, high metastatic potential, a tendency for recurrence, and poor prognosis. Patients with metastatic TNBC (mTNBC) have a poorer prognosis and a higher likelihood of early death (survival time ≤3 months). Therefore, the development of effective individualized survival prediction tools, such as prediction nomograms and web-based survival calculators, is of great importance for predicting the probability of early death in patients with metastatic TNBC.
Methods: Patients diagnosed with mTNBC in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015 were included in the model construction. Univariate and multivariate logistic regression analysis was performed to identify risk factors associated with early death in patients with mTNBC, and predictive prognostic nomograms were constructed. The accuracy of the nomograms was verified using receiver operating characteristic (ROC) curves, and GiViTi Calibration belt plots were used to evaluate the model consistency. The clinical applicability of the nomograms was evaluated using decision curve analysis (DCA). Based on the predictive prognostic nomograms, a network survival rate calculator was developed for individualized survival prediction in patients with mTNBC.
Results: A total of 2,230 patients diagnosed with mTNBC were included in the SEER database for this study. After strict exclusion criteria, 1,428 patients were found to be eligible for the study. All the patients were randomly divided into a training cohort and a validation cohort in a ratio of7:3. Independent risk factors for mTNBC, including age, tumor size, brain metastasis, liver metastasis, surgery, and chemotherapy, were identified and integrated to construct the prediction nomogram and survival calculator. Results of ROC curves, calibration curves, and DCA curves from the training and validation cohort confirmed that the developed nomogram and web-based survival calculator in this study could accurately predict the probability of early death in patients with mTNBC.
Conclusion: In this study, we developed a reliable prediction nomogram and web-based survival calculator for predicting the probability of early death in patients with mTNBC. These tools can assist clinical physicians in identifying high-risk patients and developing personalized treatment plans as early as possible.
Oral findings as a clinical tool to differentiate between lupus erythematosus and dermatomyositis patients
Authors: Robles-Silva Christian , Barrio-Díaz Pablo Del , Reyes-Vivanco Carlos , Salgueiro Catalina , Poblete María José , Abarzúa Álvaro , Vera-Kellet Cristián 
Published: April 2023

Abstract
Background Dermatomyositis (DM) patients are frequently misdiagnosed as having lupus erythematosus. There are few tools to differentiate between these diseases.Objective To compare oral findings between patients with systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE), and DM patients to explore new clinical tools that allow differentiating between these conditions.Methods We conducted an observational, transversal, and analytical study between 2016 and 2021. One hundred sixty-seven patients were included (77 SLE, 56 CLE, and 34 DM). All patients who presented with more than one of these diseases simultaneously were excluded. All patients had a clinical evaluation of the oral cavity. We obtained photographs of the tongue, hard and soft palate, upper and lower gingiva, and jugal mucosa. Three dermatologists, blinded to the diagnosis of the diseases studied, registered the presence of the lesions of interest.Results The presence of brown pigmentation in the gingiva, whitish streaks in the jugal mucosa, palatal cobblestones, and gingival cobblestones were associated with SLE and CLE when compared with DM patients. Palatal cobblestones were present exclusively in patients with SLE and CLE. Gingival telangiectasias were associated with DM when compared with SLE, and palatal telangiectasias and well-defined palatal lesions were associated with DM when compared with SLE and CLE. Most DM patients presented palatal telangiectasias (94.12%), while this finding in SLE and CLE patients was infrequent (7.79% and 5.36%, respectively).Conclusion Oral findings can help differentiate between SLE, CLE, and DM patients when there is a diagnostic dilemma between these conditions.
Dihydroartemisinin Inhibits Restenosis After Balloon Angioplasty via the CircHSPA4/miR-19a-5p Axis
Authors: Huang Renping , xing Wenjing , Wang wenjing 
Published: April 2023

Abstract
Dihydroartemisinin (DHA) inhibits restenosis following balloon angioplasty. However, data on the mechanisms of DHA activity in restenosis remains scant. Here, we investigated the role of circRNAs in mediating the inhibitory activity of DHA in neointimal formation. We used total RNA sequencing data to profile the expression of mRNA, circRNA and small RNA in sham, vascular balloon injury (VBI) and DHA-treated groups. CCK8 and EdU assays were employed to analyze cell proliferation, while qRT-PCR and Western blot were used to analyze the RNA or protein expression. In addition, we used RNA immunoprecipitation and luciferase reporter assay to assess the binding of circHSPA4 with miR-19a-5p. RNA sequencing demonstrated that circHSPA4 was upregulated in VBI. Treatment with DHA effectively suppressed the upregulation of the circHSPA4. In addition, analysis of platelet-derived growth family factor bb (PDGFbb)-induced HA-VSMCs showed upregulation of circHSPA4, which was associated with cell proliferation and differentiation. CircHSPA4 was shown to induce dedifferentiation and proliferation of smooth muscle cells. PDGFBB-induced overexpression of CircHSPA4 in HA-VSMCs led to suppression of miR-19a-5p, a phenomenon that was reversed by DHA, in concentration-dependent fashion. In addition, miR-19a-5p reduced the dedifferentiation and proliferation of the smooth muscle cells. Our data demonstrated that CircHSPA4 regulates proliferation and differentiation of smooth muscle cells. DHA and miR-19a-5p modulates CircHSPA4 and can be used as coated drugs on balloon catheter to improve the success rate of vascular remodeling.
Preparation of a series of highly efficient porous adsorbent PGMA- N and its application in the co-removal of Cu(II) and sulfamethoxazole from water
Authors: Sun Shishu , Zhang Xiaopeng , Zhang Yan , Sun Tianyi , Zhu Linhua , Shi Zaifeng , Zhang Dashuai 
Published: April 2023

Abstract
This paper presents a highly efficient porous adsorbent PGMA-N prepared through a series of amination reactions between polyglycidyl methacrylate (PGMA) and different polyamines. The obtained polymeric porous materials were characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), specific surface area test (BET), and elemental analysis (EA). Thereinto, the PGMA-EDA porous adsorbent exhibited excellent ability to synergistically remove Cu(II) ions and sulfamethoxazole from aqueous solutions. Moreover, we studied the effects of pH, contact time, temperature, and pollutant initial concentration on the adsorption performance of the adsorbent. The experimental results showed that the adsorption process of Cu(II) followed the pseudo-second-order kinetic model and Langmuir isotherm. The maximum adsorption capacity of PGMA-EDA for Cu(II) ions was 0.794 mmol/g. These results indicate that PGMA-EDA porous adsorbent has great potential for application in treating wastewater coexisting with heavy metals and antibiotics.
Biophysical and Amyloid Behaviour of a Recombinant Rab1 Isoform of Leishmania Donovani
Authors: Roshanara Roshanara , MUTHU SHIVANI , Gulafsha Gulafsha , Tandon Rati , Selvapandiyan Angamuthu , Ahmad Basir 
Published: April 2023

Abstract
The most lethal form of leishmaniasis in mammals _ kala-azar or visceral leishmaniasis, is caused by the intracellular protozoan parasite Leishmania donovani. The several phases of infection and life cycle of the parasite are regulated by Rab proteins, a small GTPase subfamily. This study uses biophysical methods to describe the pH-moderated solution characteristics of a recombinant Rab1 isoform from L. donovani (rLdRab1). The isoform unfolds on lowering the solution pH in a non-two-state route, highlighting the potential for more than one folding intermediates. At pH 2.0, a partially folded intermediate (PFI) state accumulates and exhibits properties median to the molten and pre-molten globule states. At high protein concentrations the high amyloidogenic potential of this PFI induces slow transformation into distinct protofibrils. It was also noted that the native state of the isoform was aggregation-prone. Nevertheless, amorphous aggregation rather than fibrils was formed. This is the first work, to our knowledge, to describe the amyloid-like behaviour of Rab isoforms in L donovani in vitro. This research provides an unusual alternative to comprehend the full biophysical properties of the Rab1 isoforms in the lower eukaryote L. donovani.
Productive performance and economic viability of broiler chicks fed black soldier fly larvae meal-based diets
Authors: Adegbenro M. , Ayeni Akinlolu , Akintomide A. A , Atansuyi A. J. , Agbede J.O 
Published: April 2023

Abstract
Background
This study was conducted to investigate black soldier fly larvae meal (BSFLM) as replacement for fish meal on productive performance and economic viability of broiler chicks. During processing, the live larvae were poured into heated water and stirred for about 3 – 5 minutes. Filtered larvae were spread on nylon for solar drying to minimum moisture content. Dried larvae were then milled. Two hundred and fifty Cobb 500 breed day-old chicks were randomly allotted at 50 chicks per treatment of 5 replicates using performance and cost implication as response criteria in a Completely Randomized Design. The BSFLM was used to replace fish meal at 0, 25, 50, 75 and 100% and designated diets I, II, III, IV and V, respectively. The respective diets were fed to the chicks ad libitum from 1 – 21 days.
Results
Among all the growth parameters measured, only the total feed consumed was significantly (P≤0.05) influenced by the dietary treatments. Highest total feed consumed (620.79g) and lowest total feed consumed (562.34g) were recorded in chicks fed diets I and III, respectively. Highest final weight (643.67g) and highest weight gain (602.92g) were recorded in chicks fed diet I. The net profit/started chicks was highest in chicks fed diet V. Generally, the net profit/started chicks increased as the level of BSFLM increased in the diets.
Conclusions
From this study, the replacement of fish meal with BSFLM in the diets of broiler chicks could help to reduce the over dependence of broiler producers on importation of fish meal.
Chaîne opératoires and Communities of practice in local ceramic production at Iron Age Monte Iato (Sicily, 6 th -5 th century BCE)
Authors: Öhlinger Birgit , Tenconi Marta , Maritan Lara , Montana Giuseppe , Roppa Andrea 
Published: April 2023

Abstract
The study focuses on the reconstruction of the chaîne opératoires of Iron Age pottery production at Monte Iato (Sicily, southern Italy), in terms of clay deposits selection, raw material processing and firing technology. A set of 76 specimens from the central cult place of the site (600-450 BCE) and belonging to functional categories of serving and consumption of food and drinks, food preparation, cooking and storage were analyzed using macroscopic, mineralogic and petrographic methods. As proxy data, the results deepen our insights into local potters’ technologies and choices by revealing varied and multi-layered communities of practice determined by corresponding ceramic manufacture processes. These do differ in regards of raw material procurement, clay processing as well as firing techniques but at the same time are in some extent linked together through the constant use of grog as temper – a practice detectable over the entire use of the cult site of over 100 years.
Enhancing Libyan Students' Productive Skills through Computer-Assisted Language Learning (CALL): Impacts on Writing and Speaking
Authors: ABDELATY SULIMAN 
Published: April 2023

Abstract
The purpose of this research paper is to investigate the effects of Computer-Assisted Language Learning (CALL) on the writing and speaking skills of Libyan students. The study evaluates the efficacy of CALL in enhancing Libyan students' productive language abilities and explores how technology-based learning can contribute to overcoming the challenges faced by traditional methods in teaching English as a Foreign Language (EFL). The study employs a mixed-methods approach, involving quantitative and qualitative data collection and analysis. The findings reveal significant improvements in students' writing and speaking skills and highlight the potential of CALL as an effective teaching approach in the Libyan EFL context.
COVID-19 Knowledge, Message Perceptions and Behaviors among Pregnant and Postpartum Women During the Early Months of the COVID-19 Pandemic in the United States
Authors: Brown Kyrah K. , Igenoza Oluwatosin , Gupta Shuchika , Pierre Claudy Jean , Anaman Zoe 
Published: April 2023

Abstract
Objectives: This study examined the factors associated with COVID-19 knowledge, perceptions of COVID-19 messaging related to the perinatal population, and examined the association between COVID-19 knowledge and adherence to COVID-19 preventive behaviors among pregnant and postpartum women during the first wave of the COVID-19 stay-at-home orders in the United States.
Methods: This was a cross-sectional online survey. A convenience sample of pregnant and postpartum women (18-49) were recruited from across the United States between April and June 2020—during the first wave of the COVID-19 stay-at-home orders. Crude and adjusted logistic regression analyses were performed to estimate odds ratios (OR) with 95% confidence intervals.
Results: Of the 584 participants, 22.8% correctly answered all COVID-19 knowledge questions and 85.8% correctly identified the primary COVID-19 symptoms. Participants with at least one chronic health condition (aOR=0.60, 95% CI=0.39, 0.94) and who were unmarried (aOR=, 95% CI=0.43, 0.93) had a lower odds of correctly answering COVID-19 knowledge questions. Sixty-two percent of participants reported COVID-19 messaging was consistent and 43.3% of participants reported being able to find enough COVID-19 information or resources for pregnant or postpartum women. Participants had high levels of adherence to preventive behaviors. Participants who avoided hosting small gatherings during stay-at-home orders were two time as likely to correctly answer COVID-19 knowledge questions (aOR=, (95% CI=1.15,3.66).
Discussion: The findings underline the importance of prioritizing tailored educational and care needs among pregnant and postpartum people as early as possible during a global health emergency.
Study of hydrologically critical subbasins under climate change
Authors: Gaur Shishir , Kumar Ranveer , Ohri Anurag , Mishra Shreyansh , Gond Ajeet Kumar , Dwivedi Shyam Bihari , Jha Medha , Chaturvedi Abhyanand , Singh Bhola Nath 
Published: April 2023

Abstract

This study aims to evaluate the impact of climate change on the surface water hydrology of the Gopad river basin in India. The outputs of four CMIP6 Global Climate Models have been downscaled using the statistical downscaling method to the basin level. A comparative analysis for the accuracy achieved in the bias correction for the combination of GCM and downscaling method has been performed before utilising the downscaled weather parameters for hydrological study. The MIROC6 and ACCESS-CM2 were found best for the simulation of precipitation and temperature, respectively. The Distribution Mapping and Variance Scaling methods have shown better accuracy w.r.t other statistical methods. The impact of climate change has been found significant since the temperature has been observed to be increased by 3.16 °C by the end of 2060; meanwhile, there is an average decrease of 9.2% in the annual rainfall from the baseline. The peak runoff has increased while there is a significant decrease in the groundwater recharge. Further, hydrologically critical subbasins (HCS) have been delineated based on the runoff, groundwater recharge, and baseflow. Most HCS was observed to be situated in the upper Gopad river basin, representing the area's pristine conditions.
HIGHLIGHTS
The ACCESS-CM2 and MIROC6 are more accurate for the study area. The Variance Scaling and Distribution Mapping methods have shown better accuracy than others. A rise in average temperature has been observed, while there is a decrease in annual rainfall from the baseline. The area with less human intervention has proven to be hydrologically critical for the Gopad river basin.