bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Water‐ and Base‐Stable Iminopyridine‐Based Cage That Can Bind Larger Organic Anions
Authors: Zenka Mattias , Preinl Joachim , Pertermann Eric , Lützen Arne , Tiefenbacher Konrad 
Published: March 2023

AbstractCatalysis inside molecular cages and capsules has attracted an increasing amount of attention over the last decade. While many examples of the catalysis of reactions with cationic intermediates and transition states are known, those with anionic counterparts are scarce. One limiting factor is access to suitably sized cationic iminopyridine‐based cages that are stable towards water and anionic/nucleophilic guest molecules. This study aimed at identifying such suitable cages. In this full paper, we describe the journey that finally led to the synthesis of a novel iminopyridine‐based tetrahedron that can bind larger organic anions with binding constants of up to 850 M−1 in MeCN−d3/H2O=9 : 1. Importantly, it also displays stability in basic aqueous acetonitrile. Surprisingly, investigations towards catalysis of reactions with anionic transition states did not indicate rate accelerations in the presence of the cage.
Dietary Oil Type and Late Feed Restriction Elicit Synergistic Effects on Growth, Caeca Bacteria, Carcass, Fat Accretion, and Muscle Lipids in Female Broilers
Authors: Adeyemi Kazeem D. , Sola‐Ojo Foluke E. , Ahmed El‐Imam Aminat M. , Atolani Olubunmi , Alli Oluwasayope I. , Adegboyega Abdulhafeez O. , Abubakar Shukurat O. , Obamonire Oluwatosin S. , Ologunde Felicia O. 
Published: March 2023

AbstractThe influence of dietary oil type (OT) and late feed restriction (FR) on growth, caeca bacteria count, carcass, separable fat depots, serum and muscle lipids, and meat quality in broilers is examined. In total, 224, 21‐day‐old female Arbor acres broilers are randomly allotted to either PN, Unrestricted+50 g kg−1palm oil (PO); PR, 25%‐FR+PO; SN, Unrestricted+50 g kg−1soybean oil (SO); or SR, 25%‐FR+SO for 21 d. The SN and PR birds have the heaviest and lightest body weight gain (BWG), respectively. Feed conversion ratio (FCR) is poorer in the PN birds. Feed‐restricted birds have more caecaLactobacillusand lowerSalmonella, serum cholesterol, and triglycerides. Carcass yield is higher in SR birds and lower in PN birds. The FR‐OT interaction is significant for muscle lipids and weight of fat depots. The PN birds deposit more abdominal, intramuscular, sartorial, mesentery and neck fats, muscle saturated fatty acids, and C18:1n‐9 and lower C18:3n‐3 and C20:5n‐3 than other birds. Neither OT nor FR affects the pH, color, water holding capacity, and oxidative stability of breast meat. The changes elicited by 25%‐FR on BWG, FCR, carcass yield, depot fats, and muscle lipids in female broilers are dependent on dietary OT.Practical Application: Fast growth rate and unrestricted access to feed can predispose broiler chickens to excessive fat accretion, which is counterproductive. Producing high‐quality carcasses that meet consumers’ expectation is crucial for sustainable and efficient broiler production. The possible interaction between dietary OT and late quantitative FR in mitigating excessive fat accretion and altering production indices in female broilers is explored. Late quantitative FR reduces BWG, FCR, serum lipids, caeca pH andSalmonellaspp. and fat accretion in fat depots, and enhances carcass yield and caecaLactobacillusspp. However, the impacts are more pronounced in the PO birds than the SO birds. Late FR improves the C18:3n‐3 and C18:2n‐6 contents in PO meat while reducing the C14:0 and C16:0 contents in SO meat. These findings explicate that dietary OT and late quantitative FR can be synergistically used to mitigate excessive fat accretion and alter growth, caeca microflora, and muscle lipids in broilers.
Managing Pathways for Introduction of Alien Crayfish: Evaluation of a Midwestern State's Regulations on the Pet Industry
Authors: DiStefano Robert J , Glon Mael G , O'Brian Bailey M 
Published: March 2023

Abstract
The increasing worldwide popularity of the aquatic pet trade causes widespread transport and introduction of alien species, including crayfish (Astacidea), into fisheries. Thirty crayfish species have invaded North America, affecting native species and changing ecosystems. Growing numbers of crayfish introductions are linked to the pet trade, and this pathway increasingly requires attention from natural resource managers. The Missouri Department of Conservation implemented regulations in 2014 to restrict pet store crayfish sales. We surveyed all Missouri pet stores in 2019 to estimate regulation compliance. Undercover enforcement agents visited stores and assessed crayfish sales by inspecting livestock and interviewing owners/employees. Simultaneously, we conducted a comparative survey of Ohio stores, where minimal regulations exist. Crayfish, including three alien species, were illegally sold at 15.5% of Missouri stores. In Ohio, 63% of stores sold crayfish, including three alien species. The Missouri regulations appear effective for managing and reducing pet store sales of potentially invasive crayfish.
Analysis of vein grafting versus arteriovenous loop in microvascular head and neck reconstruction: Multicenter series of 36 patients
Authors: Pak Kaitlynne Y. , Anderson Spencer R. , Langenfeld Tyler L. , Tan Kenneth , Slijepcevic Allison , Wimalawansa Sunishka , Ducic Yadranko , Wax Mark K. , Kadakia Sameep P. 
Published: March 2023

AbstractBackgroundThe utilization of an arteriovenous loop is an underreported technique that affords the creation of reliable vascular options. Understanding the efficacy and impacting variables of microvascular reconstruction with an arteriovenous loop can be critical to its use.MethodsMulti‐institutional study of 36 patients who underwent vein grafting or AV loop with free tissue transfer.Results58.3% of patients received prior radiation and 38.9% prior flap reconstruction. Flap success for vein grafting was 76% and AV loop was 100% (p = 0.16). Success for the radiated cohort was 90.5% and non‐radiated 80% (p = 0.63). Flap success for the radiated, vein grafted patient was 83.3% and 100% flap success rate for radiated, AV loop patient (p = 0.49). Overall flap survival was 83.3% versus 97% overall success rate in the United States.ConclusionThe AV loop is a viable modality for vessel‐depleted free tissue reconstruction. Radiation and previous surgery do not significantly impact flap success rates.
Long‐term prevention of bladder cancer progression by alpha1‐oleate alone or in combination with chemotherapy
Authors: Hien Tran Thi , Ambite Ines , Wan Murphy Lam Yim , Cavalera Michele , Esmaeili Parisa , Chaudhuri Arunima , Sabari Samudra , Babjuk Marek , Svanborg Catharina 
Published: March 2023

AbstractBladder cancer is common and one of the most costly cancer forms, due to a lack of curative therapies. Recently, clinical safety and efficacy of the alpha1‐oleate complex was demonstrated in a placebo‐controlled study of nonmuscle invasive bladder cancer. Our study investigated if long‐term therapeutic efficacy is improved by repeated treatment cycles and by combining alpha1‐oleate with low‐dose chemotherapy. Rapidly growing bladder tumors were treated by intravesical instillation of alpha1‐oleate, Epirubicin or Mitomycin C alone or in combination. One treatment cycle arrested tumor growth, with a protective effect lasting at least 4 weeks in mice receiving 8.5 mM of alpha1‐oleate alone or 1.7 mM of alpha‐oleate combined with Epirubicin or Mitomycin C. Repeated treatment cycles extended protection, defined by a lack of bladder pathology and a virtual absence of bladder cancer‐specific gene expression. Synergy with Epirubicin was detected at the lower alpha1‐oleate concentration and in vitro, alpha1‐oleate was shown to enhance the uptake and nuclear translocation of Epirubicin, by tumor cells. Effects at the chromatin level affecting cell proliferation were further suggested by reduced BrdU incorporation. In addition, alpha1‐oleate triggered DNA fragmentation, defined by the TUNEL assay. The results suggest that bladder cancer development may be prevented long‐term in the murine model, by alpha1‐oleate alone or in combination with low‐dose Epirubicin. In addition, the combination of alpha1‐oleate and Epirubicin reduced the size of established tumors. Exploring these potent preventive and therapeutic effects will be of immediate interest in patients with bladder cancer.
Efficacy and Safety of Minimally Invasive Thyroid Surgery: A Network Meta‐Analysis
Authors: Kim Do Hyun , Kim Sung Won , Kim Geun‐Jeon , Basurrah Mohammed A. , Hwang Se Hwan 
Published: March 2023

ObjectivesMinimally invasive and remote surgical approaches for thyroid tumors have been developed primarily for cosmetic benefit. However, conventional meta‐analysis could not provide comparative data between new techniques. This network meta‐analysis would be able to provide data for clinicians and patients to compare cosmetic satisfaction and morbidity by comparing surgical methods.Data SourcesThe PubMed, EMBASE, MEDLINE, SCOPUS, Web of Science, Cochrane Trials, and Google Scholar.Review methodsThe nine interventions included minimally invasive video‐assisted thyroidectomy (MIVA), endoscopic and robotic bilateral axillo‐breast‐approach thyroidectomy (EBAB and RBAB, respectively), endoscopic and robotic retro‐auricular thyroidectomy (EPA and RPA, respectively), endoscopic or robotic transaxillary thyroidectomy (EAx and RAx, respectively), endoscopic and robotic transoral approaches (EO and RO, respectively), and a conventional thyroidectomy. We recorded the operative outcomes and perioperative complications; pairwise and network meta‐analyses were performed.ResultsEO, RBAB, and RO were associated with good patient cosmetic satisfaction. EAx, EBAB, EO, RAx, and RBAB were associated with significantly more postoperative drainage than the other methods. Postoperatively, more flap problems and wound infections were found in the RO than control group, and more transient vocal cord palsy was found in the EAx and EBAB groups. MIVA ranked first in terms of operative time, postoperative drainage amount, postoperative pain, and hospitalization, but cosmetic satisfaction was low. EAx, RAx, and MIVA ranked higher than the other approaches in terms of operative bleeding.ConclusionIt was confirmed that minimally invasive thyroidectomy achieves high cosmetic satisfaction and is not inferior to conventional thyroidectomy in terms of surgical results or perioperative complications. Laryngoscope, 133:2470–2479, 2023
Torsion divisors of plane curves with maximal flexes and Zariski pairs
Authors: Artal Bartolo Enrique , Bannai Shinzo , Shirane Taketo , Tokunaga Hiro‐o 
Published: March 2023

AbstractThere is a close relationship between the embedded topology of complex plane curves and the (group‐theoretic) arithmetic of elliptic curves. In a recent paper, we studied the topology of some arrangements of curves that include a special smooth component, via the torsion properties induced by the divisors in the special curve associated to the remaining components, which is an arithmetic property. When this special curve has maximal flexes, there is a natural isomorphism between its Jacobian variety and the degree zero part of its Picard group. In this paper, we consider curve arrangements that contain a special smooth component with a maximal flex and exploit these properties to obtain Zariski tuples, which show the interplay between topology, geometry, and arithmetic.
Volunteers and resource management competencies of nonprofit organizations during challenging times
Authors: Lee Jeongyoon , Park Young Joo , Kim Sung‐eun 
Published: March 2023

AbstractNonprofit organizations increasingly compete for limited resources and recognize volunteers as vital assets. That said, which nonprofits are more successful in harnessing volunteers than others and enlisting more volunteers while responding to environmental changes? Guided by the resource‐based theory, this study theorizes that a nonprofit's human, social, and financial resource management competencies relate to its volunteer use. Also, applying contingent resource‐based theory extends our theoretical arguments as to why a nonprofit needs to develop its resource management competencies for the use of volunteers facing a community's financial hardship. Our zero‐inflated negative binomial analysis using the IRS 990 and U.S. Census data (2010–2012) finds that (1) a nonprofit's higher human, social, and financial resource management competencies have an important influence on using volunteers, and (2) a nonprofit having higher financial resource management competencies can use more volunteers when its community experiences economic hardship. These findings pinpoint that volunteer use is not separable from organizational holistic resource management competencies and suggest that turbulent environments can cause a significant shift in the management competencies required for volunteer use.
“KARER” intervention on care ability and burden for caregiving relatives of disabled patients with cardiocerebrovascular diseases: EMICARE mixed randomized clinical protocol
Authors: Molina Cardona Edith Milena , Contreras Moreno Jeffersson Ricardo , Puerto Pedraza Henry Mauricio , Moscoso Loaiza Luisa Fernanda , Sánchez Rodríguez Javier Mauricio 
Published: March 2023

AbstractAimsDetermine efficacy of “KARER” educational intervention on caring ability and burden of caregiving relatives of disabled patients with stroke and cardiovascular diseases.DesignClinical, randomized, controlled and double blinded trial with a mixed approach.MethodsStudy population will be made up of 96 caregiving relatives of patients of home‐hospitalized care programs in the cities of Bogotá and Bucaramanga, (Colombia), between March 2021 and March 2022. Participants will be randomly assigned into two groups, either intervention (n = 48) or control (n = 48). The intervention is interdisciplinary and multi‐component: B‐Learning modality and clinical simulation. Follow‐up of participants will last 8 weeks from intervention period start‐out, and measurements will be taken and analysed in masked form. The main results will be the mean score changes of care ability and caregiver burden.DiscussionCaregiving relatives will show better adaptation to their role through effective use of caring abilities as they look after disabled persons with chronic diseases.
Weight loss maintenance after a digital commercial behavior change program (Noom Weight): Observational cross‐sectional survey study
Authors: May Christine N. , Cox‐Martin Matthew , Ho Annabell Suh , McCallum Meaghan , Chan Caroline , Blessing Kelly , Behr Heather , Blanco Paige , Mitchell Ellen Siobhan , Michaelides Andreas 
Published: March 2023

AbstractBackgroundBehavioral weight loss programs often lead to significant short‐term weight loss, but long‐term weight maintenance remains a challenge. Most weight maintenance data come from clinical trials, in‐person programs, or general population surveys, but there is a need for better understanding of long‐term weight maintenance in real‐world digital programs.MethodsThis observational survey study examined weight maintenance reported by individuals who had used Noom Weight, a digital commercial behavior change program, and identified factors associated with greater weight maintenance. The cross‐sectional survey was completed by 840 individuals who had lost at least 10% of their body weight using Noom Weight 6–24 months prior.ResultsThe study found that 75% of individuals maintained at least 5% weight loss after 1 year, and 49% maintained 10% weight loss. On average, 65% of initial weight loss was maintained after 1 year and 57% after 2 years. Habitual behaviors, such as healthy snacking and exercise, were associated with greater weight maintenance, while demographic factors were not.ConclusionThis study provides real‐world data on the long‐term weight maintenance achieved using a fully digital behavioral program. The results suggest that Noom Weight is associated with successful weight maintenance in a substantial proportion of users. Future research will use a randomized controlled trial to track weight maintenance after random assignment and at a 2 year follow‐up.
Electrospinning behavior and piezoelectric property of PVDF/PEDOT:PSS composite web by PEDOT:PSS addition
Authors: Lim Jihwan , Choi Sejin , Kim Han Seong 
Published: March 2023

AbstractPoly(vinylidene fluoride) (PVDF) is a representative piezoelectric polymer with a high piezoelectric constant, which has been applied and studied in various fields because of its flexibility. PVDF has various crystallization phases, and the crystallization phase of the fabricated fibers is significantly influenced by the solution characteristics and additives during the electrospinning process. Poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is a conductive polymer that can improve piezoelectric performance by acting as an electron path when combined with a piezoelectric polymer; however, the electrospinning behavior depends on the solution properties. The characteristics of composite solutions with PEDOT:PSS added to PVDF were investigated, and the changes in electrospinning behavior and morphology were analyzed accordingly. We also evaluated the crystallinity of the PVDF in the deposited fibers using Fourier‐transform infrared (FTIR) spectroscopy and X‐ray diffraction (XRD) analysis. As the PEDOT:PSS content increased, the radius of the jet decreased, the deposition area decreased, the fiber diameter tended to increase, and the crystallinity of the β phase decreased. Changes in the piezoelectric performance of the PVDF/PEDOT composite webs with various PEDOT:PSS contents were investigated and analyzed. Based on the results of this study, ceramic‐based materials can be replaced with improved polymer‐based piezoelectric elements, thus accelerating the adoption of wearable piezoelectric devices.
Associations of prognostic‐awareness‐transition patterns with emotional distress and quality of life during terminally ill cancer patients' last 6 months of life
Authors: Chen Chen Hsiu , Wen Fur‐Hsing , Chang Wen‐Cheng , Hsieh Chia‐Hsun , Chou Wen‐Chi , Chen Jen‐Shi , Tang Siew Tzuh 
Published: March 2023

AbstractObjectiveUnprecedently investigate associations of prognostic‐awareness‐transition patterns with (changes in) depressive symptoms, anxiety symptoms, and quality of life (QOL) during cancer patients' last 6 months.MethodsIn this secondary analysis study, 334 cancer patients in their last 6 months transitioned between four prognostic‐awareness states (unknown and not wanting to know, unknown but wanting to know, inaccurate awareness, and accurate awareness), thus constituting three transition patterns: maintaining‐accurate‐, gaining‐accurate‐, and maintaining‐inaccurate/unknown prognostic awareness. A multivariate hierarchical linear model evaluated associations of the transition patterns with depressive symptoms, anxiety symptoms, and QOL determined at final assessment and by mean difference between the first and last assessment.ResultsAt the last assessment before death, the gaining‐accurate‐prognostic‐awareness group reported higher levels of depressive symptoms (estimate [95% confidence interval] = 1.59 [0.35–2.84]) and the maintaining‐ and gaining‐accurate‐prognostic‐awareness groups suffered more anxiety symptoms (1.50 [0.44–2.56]; 1.42 [0.13–2.71], respectively) and poorer QOL (−7.07 [−12.61 to 1.54]; −11.06 [−17.76 to −4.35], respectively) than the maintaining‐inaccurate/unknown‐prognostic‐awareness group. Between the first and last assessment, the maintaining‐ and gaining‐accurate‐prognostic‐awareness groups' depressive symptoms (1.59 [0.33–2.85]; 3.30 [1.78–4.82], respectively) and QOL (−5.04 [−9.89 to –0.19]; −8.86 [−14.74 to −2.98], respectively) worsened more than the maintaining‐inaccurate/unknown‐prognostic‐awareness group, and the gaining‐accurate‐prognostic‐awareness group's depressive symptoms increased more than the maintaining‐accurate‐prognostic‐awareness group (1.71 [0.42–3.00]).ConclusionsUnexpectedly, patients who maintained/gained accurate prognostic awareness suffered more depression, anxiety, and poorer QOL at end of life. Promoting accurate prognostic awareness earlier in the terminal‐cancer trajectory should be supplemented with adequate psychological care to alleviate patients' emotional distress and enhance QOL.Trial registration: ClinicalTrials.gov:NCT01912846.
Optimised plasma sample preparation and LC‐MS analysis to support large‐scale proteomic analysis of clinical trial specimens: Application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial
Authors: O'Rourke Matthew B. , Januszewski Andrzej S. , Sullivan David R. , Lengyel Imre , Stewart Alan J. , Arya Swati , Ma Ronald C. , Galande Sanjeev , Hardikar Anandwardhan A. , Joglekar Mugdha V. , Keech Anthony C. , Jenkins Alicia J. , Molloy Mark P. 
Published: March 2023

AbstractPurposeRobust, affordable plasma proteomic biomarker workflows are needed for large‐scale clinical studies. We evaluated aspects of sample preparation to allow liquid chromatography‐mass spectrometry (LC‐MS) analysis of more than 1500 samples from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial of adults with type 2 diabetes.MethodsUsing LC‐MS with data‐independent acquisition we evaluated four variables: plasma protein depletion, EDTA or citrated anti‐coagulant blood collection tubes, plasma lipid depletion strategies and plasma freeze–thaw cycles. Optimised methods were applied in a pilot study of FIELD participants.ResultsLC‐MS of undepleted plasma conducted over a 45 min gradient yielded 172 proteins after excluding immunoglobulin isoforms. Cibachrome‐blue‐based depletion yielded additional proteins but with cost and time expenses, while immunodepleting albumin and IgG provided few additional identifications. Only minor variations were associated with blood collection tube type, delipidation methods and freeze–thaw cycles. From 65 batches involving over 1500 injections, the median intra‐batch quantitative differences in the top 100 proteins of the plasma external standard were less than 2%. Fenofibrate altered seven plasma proteins.Conclusions and clinical relevanceA robust plasma handling and LC‐MS proteomics workflow for abundant plasma proteins has been developed for large‐scale biomarker studies that balance proteomic depth with time and resource costs.