bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of consumer acceptance of gene‐edited foods and its implications for innovators and policymakers
Authors: Paudel Bindu , Kolady Deepthi E. , Just David , Van der Sluis Evert 
Published: February 2023

AbstractGene‐editing is a breakthrough technology for crop improvement that addresses many concerns associated with its predecessor and distinctly different technology, genetically modified crops. The commercial success of gene‐editing technology depends on the public's acceptance of its foods. This study used data from a national survey of United States consumers to identify the determinants of consumer acceptance of gene‐edited foods and compared them with those of genetically modified foods. Our study shows that consumer awareness and knowledge of gene‐edited foods are almost half those of genetically modified foods. In the study, we classified survey respondents in three clusters based on their attitudes toward food technologies and corporate distrust: technology‐loving, neutral, and technology‐averse. The technology‐averse cluster has the greatest share of individuals who indicated being aware of and knowledgeable about gene‐edited foods, and the largest share of respondents who stated having negative views toward agricultural biotechnology. Technology‐loving individuals have more positive perceptions about agricultural biotechnology and are more likely to consume genetically modified and gene‐edited foods in the future than neutral and technology‐averse individuals. Findings indicate that providing information on the technology and its health and environmental benefits did not affect consumers' willingness to consume genetically modified and gene‐edited foods. Prior perceptions of agricultural biotechnology, beliefs about safety, benefits, labeling, and the type of technology developer are important determinants of anticipated future consumption of genetically modified and gene‐edited foods. [EconLit Citations: Q13, Q16].
Younger haploidentical donor versus older matched unrelated donor for patients with AML/MDS
Authors: Marcoux Curtis , Marin David , Ramdial Jeremy , AlAtrash Gheath , Alousi Amin M. , Oran Betul , Kebriaei Partow , Popat Uday R. , Rezvani Katayoun , Champlin Richard E. , Shpall Elizabeth J. , Mehta Rohtesh S. 
Published: February 2023

AbstractOptimal donor selection is fundamental to successful allogeneic hematopoietic cell transplantation (HCT), and donor age influences survival after both matched unrelated donor (MUD) and haploidentical donor HCT. Though recent studies have shown similar outcomes between MUD and haploidentical HCT, it is unknown if outcomes differ following HCT with younger haploidentical donors compared to HCT with older MUDs. Therefore, we performed a retrospective analysis comparing outcomes of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) patients who underwent HCT with younger (≤35 years) haploidentical donors (n = 494) or older (>35 years) MUDs (n = 1005). Patients in the haploidentical and MUD groups received post‐transplant cyclophosphamide (PTCy) and conventional graft‐versus‐host‐disease (GVHD) prophylaxis, respectively. In multivariate analysis, use of younger haploidentical donors was associated with improved overall survival (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.69–0.95, p = .01) and lower rates of grade II‐IV acute GVHD (HR 0.64, 95% CI 0.53–0.77, p < .001), grade III‐IV acute GVHD (HR 0.37, 95% CI 0.25–0.53, p < .001), and chronic GVHD (HR 0.49, 95% CI 0.40–0.60, p < .001). Relapse rates were similar among those who received myeloablative conditioning but were higher in patients of the younger haploidentical group who received reduced intensity conditioning (HR 1.49, 95%CI 1.18–1.88, p = .001). The younger haploidentical group had significantly lower non‐relapse mortality ≥3 months post‐HCT (HR 0.59, 95% CI 0.38–0.90, p = .02). Our data support the use of younger haploidentical donors with PTCy over older MUDs with conventional prophylaxis in patients with MDS or AML. Further studies on the importance of donor age in haploidentical and MUD HCT with PTCy prophylaxis are warranted.
First implication of MIP in bilateral microphthalmia with persistent fetal vasculature
Authors: Santorini Mélissa , Chesneau Bertrand , Koskas‐Boublil Patricia , Metge Florence , Caputo Georges , Chassaing Nicolas , Martin Gilles , Plaisancié Julie 
Published: February 2023

AbstractPersistent fetal vasculature (PFV) is a rare malformative ocular disorder resulting from the failure of the hyaloid vasculature to regress. The severity of the visual impairment is depending on the underlying eye defects, ranging from discreet hyaloid remnants to severe ocular anomalies. Although PFV is generally unilateral, sporadic and idiopathic, a genetic cause has been described in some individuals, especially those presenting with a bilateral and/or syndromic form of PFV. The genes occasionally described in PFV are most often responsible for a wide spectrum of ocular phenotypes such as ATOH7 or NDP, a gene also known to be involved in Norrie disease, a X‐linked vitreoretinopathy with extra‐ocular features. We describe here a patient with an ocular phenotype consisting in non‐syndromic bilateral PFV with cataract and microphthalmia, in whom a recurrent heterozygous de novo MIP disease‐causing variant was detected after using a dedicated 119‐ocular genes panel approach. Defects in the MIP gene are classically associated with dominant non‐syndromic congenital cataract without other ocular malformative features. Thus, this case highlights the value of exploring individuals with PFV, even those with non‐syndromic forms. It also broadens the phenotypic spectrum of the MIP gene, adding new insights into the gene networks underlying PFV pathophysiology, that remains unclear.
Circulating cardiac biomarkers, structural brain changes, and dementia: Emerging insights and perspectives
Authors: Jensen Märit , Zeller Tanja , Twerenbold Raphael , Thomalla Götz 
Published: February 2023

AbstractDiseases of the heart and brain are strongly linked to each other, and cardiac dysfunction is associated with cognitive decline and dementia. This link between cardiovascular disease and dementia offers opportunities for dementia prevention through prevention and treatment of cardiovascular risk factors and heart disease. Increasing evidence suggests the clinical utility of cardiac biomarkers as risk markers for structural brain changes and cognitive impairment. We propose the hypothesis that structural brain changes are the link between impaired cardiac function, as captured by blood‐based cardiac biomarkers, and cognitive impairment. This review provides an overview of the literature and illustrates emerging insights into the association of markers of hemodynamic stress (natriuretic peptides) and markers of myocardial injury (cardiac troponins) with imaging findings of brain damage and cognitive impairment or dementia. Based on these findings, we discuss potential pathophysiological mechanisms underlying the association of cardiac biomarkers with structural brain changes and dementia. We suggest testable hypotheses and a research plan to close the gaps in understanding the mechanisms linking vascular damage and neurodegeneration, and to pave the way for targeted effective interventions for dementia prevention. From a clinical perspective, cardiac biomarkers open the window for early identification of patients at risk of dementia, who represent a target population for preventive interventions targeting modifiable cardiovascular risk factors to avert cognitive decline and dementia.
Mitochondrial transplantation ameliorates hippocampal damage following status epilepticus
Authors: Jia Xiaoxia , Wang Qinghua , Ji Jianlun , Lu Wenchun , Liu Zhidong , Tian Hao , Guo Lin , Wang Yun 
Published: February 2023

AbstractBackgroundHippocampal damage caused by status epilepticus (SE) can bring about cognitive decline and emotional disorders, which are common clinical comorbidities in patients with epilepsy. It is therefore imperative to develop a novel therapeutic strategy for protecting hippocampal damage after SE. Mitochondrial dysfunction is one of contributing factors in epilepsy. Given the therapeutic benefits of mitochondrial replenishment by exogenous mitochondria, we hypothesized that transplantation of mitochondria would be capable of ameliorating hippocampal damage following SE.MethodsPilocarpine was used to induced SE in mice. SE‐generated cognitive decline and emotional disorders were determined using novel object recognition, the tail suspension test, and the open field test. SE‐induced hippocampal pathology was assessed by quantifying loss of neurons and activation of microglia and astrocytes. The metabolites underlying mitochondrial transplantation were determined using metabonomics.ResultsThe results showed that peripheral administration of isolated mitochondria could improve cognitive deficits and depressive and anxiety‐like behaviors. Exogenous mitochondria blunted the production of reactive oxygen species, proliferation of microglia and astrocytes, and loss of neurons in the hippocampus. The metabonomic profiles showed that mitochondrial transplantation altered multiple metabolic pathways such as sphingolipid signaling pathway and carbon metabolism. Among potential affected metabolites, mitochondrial transplantation decreased levels of sphingolipid (d18:1/18:0) and methylmalonic acid, and elevated levels of D‐fructose‐1,6‐bisphosphate.ConclusionTo the best of our knowledge, these findings provide the first direct experimental evidence that artificial mitochondrial transplantation is capable of ameliorating hippocampal damage following SE. These new findings support mitochondrial transplantation as a promising therapeutic strategy for epilepsy‐associated psychiatric and cognitive disorders.
An Isotope‐Labeled Single‐Cell Raman Spectroscopy Approach for Tracking the Physiological Evolution Trajectory of Bacteria toward Antibiotic Resistance
Authors: Yang Kai , Xu Fei , Zhu Longji , Li Hongzhe , Sun Qian , Yan Aixin , Ren Bin , Zhu Yong‐Guan , Cui Li 
Published: February 2023

AbstractUnderstanding evolution of antibiotic resistance is vital for containing its global spread. Yet our ability to in situ track highly heterogeneous and dynamic evolution is very limited. Here, we present a new single‐cell approach integrating D2O‐labeled Raman spectroscopy, advanced multivariate analysis, and genotypic profiling to in situ track physiological evolution trajectory toward resistance. Physiological diversification of individual cells from isogenic population with cyclic ampicillin treatment is captured. Advanced multivariate analysis of spectral changes classifies all individual cells into four subsets of sensitive, intrinsic tolerant, evolved tolerant and resistant. Remarkably, their dynamic shifts with evolution are depicted and spectral markers of each state are identified. Genotypic analysis validates the phenotypic shift and provides insights into the underlying genetic basis. The new platform advances rapid phenotyping resistance evolution and guides evolution control.
Tandem Electrocatalytic Nitrate Reduction to Ammonia on MBenes
Authors: Zhang Guike , Li Xiaotian , Chen Kai , Guo Yali , Ma Dongwei , Chu Ke 
Published: February 2023

AbstractWe demonstrate the great feasibility of MBenes as a new class of tandem catalysts for electrocatalytic nitrate reduction to ammonia (NO3RR). As a proof of concept, FeB2is first employed as a model MBene catalyst for the NO3RR, showing a maximum NH3‐Faradaic efficiency of 96.8 % with a corresponding NH3yield of 25.5 mg h−1 cm−2at −0.6 V vs. RHE. Mechanistic studies reveal that the exceptional NO3RR activity of FeB2arises from the tandem catalysis mechanism, that is, B sites activate NO3−to form intermediates, while Fe sites dissociate H2O and increase *H supply on B sites to promote the intermediate hydrogenation and enhance the NO3−‐to‐NH3conversion.
Enforced Electronic‐Donor‐Acceptor Complex Formation in Water for Photochemical Cross‐Coupling
Authors: Tian Ya‐Ming , Hofmann Evamaria , Silva Wagner , Pu Xiang , Touraud Didier , Gschwind Ruth M. , Kunz Werner , König Burkhard 
Published: February 2023

AbstractThe amino alcohol meglumine solubilizes organic compounds in water and enforces the formation of electron donor acceptor (EDA) complexes of haloarenes with indoles, anilines, anisoles or thiols, which are not observed in organic solvents. UV‐A photoinduced electron transfer within the EDA complexes induces the mesolytic cleavage of the halide ion and radical recombination of the arenes leading, after rearomatization and proton loss to C−C or C−S coupling products. Depending on the substitution pattern selective and unique cross‐couplings are observed. UV and NMR measurements reveal the importance of the assembly for the photoinduced reaction. Enforced EDA aggregate formation in water allows new activation modes for organic photochemical synthesis.
Copper(I) Photocatalyzed Bromonitroalkylation of Olefins: Evidence for Highly Efficient Inner‐Sphere Pathways
Authors: Reichle Alexander , Koch Magdalena , Sterzel Hannes , Großkopf Lea‐Joy , Floss Johannes , Rehbein Julia , Reiser Oliver 
Published: February 2023

AbstractWe report the visible light‐mediated copper‐catalyzed vicinal difunctionalization of olefins utilizing bromonitroalkanes as ATRA reagents. This protocol is characterized by high yields and fast reaction times under environmentally benign reaction conditions with exceptional scope, allowing the rapid functionalization of both activated and unactivated olefins. Moreover, late‐stage functionnalization of biologically active molecules and upscaling to gram quantities is demonstrated, which offers manifold possibilities for further transformations, e.g. access to nitro‐ and aminocyclopropanes. Besides the synthetic utility of the title transformation, this study undergirds the exclusive role of copper in photoredox catalysis showing its ability to stabilize and interact with radical intermediates in its coordination sphere. EPR studies suggest that such interactions can even outperform a highly favorable cyclization of transient to persistent radicals contrasting iridium‐based photocatalysts.
Synthesis of Cyclopentadiene and Methylcyclopentadiene with Xylose or Extracted Hemicellulose
Authors: Yu Zhenjie , Zou Zhufan , Wang Ran , Li Guangyi , Wang Aiqin , Cong Yu , Zhang Tao , Li Ning 
Published: February 2023

AbstractCyclopentadiene (CPD) and methylcyclopentadiene (MCPD) are important intermediates that have been widely used in the production of high‐energy‐density rocket fuels, polymers and valuable chemicals. Currently, CPD and MCPD are produced from fossil energies at very low yields, which greatly limits their application. As a solution to this problem, we disclose an alternative two‐step bio‐route to access CPD and MCPD using xylose or extracted hemicellulose as the feedstock. In the first step, cyclopentanone (CPO) was directly produced by the selective hydrogenolysis of xylose or extracted hemicellulose over a commercial Ru/C catalyst in an acid‐free toluene/NaCl aqueous solution biphasic system. In the second step, CPO was selectively converted to CPD by a cascade hydrodeoxygenation/dehydrogenation reaction over zinc molybdate catalysts. When methanol was introduced with CPO and hydrogen, MCPD was selectively obtained by a cascade dehydrogenation/aldol condensation/selective hydrodeoxygenation reaction over zinc molybdate catalysts.
Enhanced tensile properties of ultra‐high molecular weight polyethylene fibers by solubility improvement with mixed solvents
Authors: Wang Yi , Wang Xinwei , Fu Jiabin , Yu Junrong , Wang Yan , Hu Zuming 
Published: February 2023

AbstractThe tensile properties of ultra‐high molecular weight polyethylene (UHMWPE) fibers obtained from mixed solvents are addressed by virtue of improved solubility. In this work, olive oil (OO) was introduced as a poor solvent for the pre‐swelling of UHMWPE in decalin, and its mass percentage was intended to be 10, 20, 30, and 40 wt% of UHMWPE. Then UHMWPE fibers with high molecular weight retention and low entanglement were prepared with paraffin oil as spinning solvent by gel‐spinning and hot‐drawing. Unlike other samples, there is a more significant molecular chain disentanglement and higher molecular weight retention for UHMWPE fibers as OO addition is 20 wt%. Surprisingly, obtained UHMWPE fibers exhibit tensile strength up to 33.85 cN/dtex and tensile modulus of 1673.27 cN/dtex, with an increase of 24.0% and 32.3%, respectively, compared with that of UHMWPE fibers without decalin/OO pre‐swelling. Furthermore, the obtained UHMWPE fibers are accompanied by a marked improvement in melting temperature, crystallization and orientation.
Interpenetrating network structure design and corrosion resistance of high‐performance waterborne polyurethane coating modified by epoxy resin and functionalized graphene oxide
Authors: Pu Zejun , Pang Jiahong , He Xiaohang , Zhu Rongli , Zhong Jiachun , Liu Xiaobo , Jiang Diyong , Ning ZhongPei 
Published: February 2023

AbstractTo obtain graphene oxide (GO) derivatives‐based waterborne polyurethane (WPU) composite coatings with high anti‐corrosion performance, microstructure, dispersion and interfacial adhesion of the coatings are key factors to consider. In this study, the waterborne polyurethane modified by epoxy resin (WEPU) and graphene oxide (GO) derivatives was synthesized by copolymerization, and its synergistic effect on the anti‐corrosion properties of waterborne polyurethane (WPU) coating was investigated. For this purpose, the isophorone diisocyanate (IPDI) was grafted to the surface of GO. Then, the functionalized GO (iGO) was uniformly dispersed in the WEPU emulsions by a prepolymer method, which was attributed to strong interaction between iGO and WEPU, as proved by FTIR spectra and SEM images. The deterioration process of WEPU and iGO‐WEPU coatings during the long‐term immersion in 3.5 wt% NaCl solution was investigated by electrochemical impedance spectroscopy (EIS). The results indicated that the introduction of well dispersed iGO nanosheets into WEPU system enhanced the corrosion protection performance to substrate. Significantly, for the 0.9 wt% iGO nanosheets reinforced WEPU composite films, the contact angle value of iGO‐WEPU composite films (94.7°) reaches the highest in comparison with that of pure WEPU film (88°), thus remarkably improving the water barrier property of iGO‐WEPU coating.
Breaching the frame: Psychoanalysis and sunset boulevard
Authors: Kaul Nilofer 
Published: February 2023

AbstractSunset Boulevard is a film that breaches the frames that cinema has conventionally used. It playfully satirises Hollywood with its silent era, its glossy nostalgia, its mystique that conceals its brittle cynicism. Norma Desmond is satirised but she is also the means by which Hollywood stands exposed. In many ways, the audience like Joe Gillis thinks they are in on the joke, till it turns against them. This paper argues that we can read this as a cautionary tale for psychoanalysts as we enter into an analysis of the patient, only to discover that we have been recruited into a world that never was in our control.
Winds in ultraluminous X‐ray sources: New challenges
Authors: Pinto C. , Kosec P. 
Published: February 2023

AbstractUltraluminous X‐ray sources (ULXs) are extreme X‐ray binaries shining above 1039erg/s, in most cases as a consequence of super‐Eddington accretion onto neutron stars and stellar‐mass black holes accreting above their Eddington limit. This was understood after the discovery of coherent pulsations, cyclotron lines, and powerful winds. The latter was possible thanks to the high‐resolution X‐ray spectrometers aboardXMM‐Newton. ULX winds carry a huge amount of power owing to their relativistic speeds (0.1–0.3c) and are able to significantly affect the surrounding medium, likely producing the observed 100 pc ULX superbubbles, and limit the amount of matter that can reach the central accretor. The study of ULX winds is therefore quintessential to understand (1) how much and how fast can matter be accreted by compact objects and (2) how strong is their feedback on the surrounding medium. This is also relevant to understand supermassive black holes growth. Here we provide an overview on this phenomenology, highlight some recent, exciting results and show how future missions such asXRISM,eXTP, andATHENAwill improve our understanding.
Consistency tests of structure formation simulations of scalar field dark matter
Authors: Medellín‐González Stefany G. , González‐Morales Alma X. , Ureña‐López L. Arturo 
Published: February 2023

AbstractThe so‐called scalar field dark matter model assumes that dark matter is an ultralight axon, with its De Broglie wavelength around λ ∼ 1kpc. This can lead to a scale suppression of the mass power spectrum at sub‐galactic scales, as compared with the standard cosmological model Λcold dark matter. In this work, we show numerical tests of cosmological simulations of scalar field dark matter using an amended version of the code MG‐PICOLA with a double purpose: to validate the results in (Medellín‐González et al. 2021), and extend them to higher numerical resolutions. Our cosmological observable of interest is the mass power spectrum, and we make dedicated comparisons with that of cold dark matter to quantify the differences in the nonlinear growth of density perturbations in both models.
In vitro and ex vivo experimental models for evaluation of intranasal systemic drug delivery as well as direct nose‐to‐brain drug delivery
Authors: Haasbroek‐Pheiffer Anja , Van Niekerk Suzanne , Van der Kooy Frank , Cloete Theunis , Steenekamp Jan , Hamman Josias 
Published: February 2023

AbstractThe intranasal route of administration provides a noninvasive method to deliver drugs into the systemic circulation and/or directly into the brain. Direct nose‐to‐brain drug delivery offers the possibility to treat central nervous system diseases more effectively, as it can evade the blood–brain barrier. In vitro and ex vivo intranasal models provide a means to investigate physiological and pharmaceutical factors that could play a role in drug delivery across the nasal epithelium as well as to determine the mechanisms involved in drug absorption from the nose. The development and implementation of cost‐effective pharmacokinetic models for intranasal drug delivery with good in vitro‐in vivo correlation can accelerate pharmaceutical drug product development and improve economic and ecological aspects by reducing the time and costs spent on animal studies. Special considerations should be made with regard to the purpose of the in vitro/ex vivo study, namely, whether it is intended to predict systemic or brain delivery, source and site of tissue or cell sampling, viability window of selected model, and the experimental setup of diffusion chambers. The type of model implemented should suit the relevant needs and requirements of the project, researcher, and interlaboratory. This review aims to provide an overview of in vitro and ex vivo models that have been developed to study intranasal and direct nose‐to‐brain drug delivery.