bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Acute Lymphoblastic Leukemia Intercontinental-Berlin-Frankfurt-Münster 2009 Trial
Authors: Campbell Myriam , Kiss Csongor , Zimmermann Martin , Riccheri Cecilia , Kowalczyk Jerzy , Felice Maria S. , Kuzmanovic Milos , Kovacs Gabor , Kosmidis Helen , Gonzalez Alejandro , Bilic Ernest , Castillo Luis , Kolenova Alexandra , Jazbec Janez , Popa Alexander , Konstantinov Dobrin , Kappelmayer Janos , Szczepanski Tomasz , Dworzak Michael , Buldini Barbara , Gaipa Giuseppe , Marinov Neda , Rossi Jorge , Nagy Attila , Gaspar Imre , Stary Jan , Schrappe Martin 
Published: May 2023

PURPOSE The International Berlin-Frankfurt-Münster (BFM) study group conducted a study on pediatric acute lymphoblastic leukemia (ALL). Minimal residual disease (MRD) was assessed using flow cytometry (FCM), and the impact of early intensification and methotrexate (MTX) dose on survival was evaluated. PATIENTS AND METHODS We included 6,187 patients younger than 19 years. MRD by FCM refined the risk group definition previously used in the ALL intercontinental-BFM 2002 study on the basis of age, WBC count, unfavorable genetic aberrations, and treatment response measured morphologically. Patients at intermediate risk (IR) and high risk (HR) were randomly assigned to protocol augmented protocol I phase B (IB) versus IB regimen. MTX doses of 2 versus 5 g/m2 every 2 weeks, four times, were evaluated in precursor B-cell-ALL (pcB-ALL) IR. RESULTS The 5-year event-free survival (EFS ± SE) and overall survival (OS ± SE) rates were 75.2% ± 0.6% and 82.6% ± 0.5%, respectively. Their values in risk groups were standard risk (n = 624), 90.7% ± 1.4% and 94.7% ± 1.1%; IR (n = 4,111), 77.9% ± 0.7% and 85.7% ± 0.6%; and HR (n = 1,452), 60.8% ± 1.5% and 68.4% ± 1.4%, respectively. MRD by FCM was available in 82.6% of cases. The 5-year EFS rates in patients randomly assigned to protocol IB (n = 1,669) and augmented IB (n = 1,620) were 73.6% ± 1.2% and 72.8% ± 1.2%, respectively ( P = .55), while those in patients receiving MTX doses of 2 g/m2 (n = 1,056) and MTX 5 g/m2 (n = 1,027) were 78.8% ± 1.4% and 78.9% ± 1.4%, respectively ( P = .84). CONCLUSION The MRDs were successfully assessed using FCM. An MTX dose of 2 g/m2 was effective in preventing relapse in non-HR pcB-ALL. Augmented IB showed no advantages over the standard IB. [Media: see text]
Quantitative analysis method for extraordinary optical transmission of thin microcavity by the catastrophic theory
Authors: Zhang Lin , Wu Jiu Hui 
Published: May 2023

Abstract
Extraordinary optical transmission (EOT) can be regarded as a phase transition process based on the variation of the aperture of the thin microcavity by the published results. Considering that the catastrophe theory could describe quantitatively any phase transition process, a novel method is proposed to analyze the EOT transition quantitatively based on a cusp catastrophic model with dimensionless analysis. The quantitative relationship of transmitted energy spectral density is fully obtained, which is also related to the aperture radius and incident electromagnetic frequency. Furthermore, from this method, a quantum transition factor is derived strictly to describe the EOT transition process, which can be divided into wave region, wave-particle duality region and quantum region with the factor increasing from 0 to 1, and Bethe's aperture theory stating that transmission is proportional to

is only one of our special cases in the wave region. Finally, the influence of the aperture and the frequency of incident wave on the EOT transmittance is analysed, and the catastrophic model is verified by previous experiments. The novel method of transition analysis provides a new insight into the EOT.
Provably Good Solutions to the Knapsack Problem via Neural Networks of Bounded Size
Authors: Hertrich Christoph , Skutella Martin 
Published: May 2023

The development of a satisfying and rigorous mathematical understanding of the performance of neural networks is a major challenge in artificial intelligence. Against this background, we study the expressive power of neural networks through the example of the classical NP-hard knapsack problem. Our main contribution is a class of recurrent neural networks (RNNs) with rectified linear units that are iteratively applied to each item of a knapsack instance and thereby compute optimal or provably good solution values. We show that an RNN of depth four and width depending quadratically on the profit of an optimum knapsack solution is sufficient to find optimum knapsack solutions. We also prove the following tradeoff between the size of an RNN and the quality of the computed knapsack solution: for knapsack instances consisting of n items, an RNN of depth five and width w computes a solution of value at least [Formula: see text] times the optimum solution value. Our results build on a classical dynamic programming formulation of the knapsack problem and a careful rounding of profit values that are also at the core of the well-known fully polynomial-time approximation scheme for the knapsack problem. A carefully conducted computational study qualitatively supports our theoretical size bounds. Finally, we point out that our results can be generalized to many other combinatorial optimization problems that admit dynamic programming solution methods, such as various shortest path problems, the longest common subsequence problem, and the traveling salesperson problem. History: Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. An extended abstract of this article, including Figures 1 – 7 , appeared in the Proceedings of the AAAI Conference on Artificial Intelligence, vol. 35, 7685–7693 ( Hertrich and Skutella 2021 ); see https://ojs.aaai.org/index.php/AAAI/article/view/16939 ; copyright © 2021, Association for the Advancement of Artificial Intelligence. Funding: This work was supported by the Deutsche Forschungsgemeinschaft [Grants DFG-GRK 2434 and EXC-2046/1, Project 390685689] and the H2020 European Research Council [ScaleOpt-757481].
Pulse-shaped high-energy and high-average-power fiber laser in the nanosecond regime
Authors: Wang Jianlei , Wang Chao , Zhang Ning , Lu Jingqi , Li Hongde , Li Xinghua , Liu Yuandong , Ueda Kenichi , Wang Chun , Zhuo Zhuang 
Published: May 2023

A high-energy and high-average-power pulsed fiber laser has been
investigated in a master oscillator power amplifier (MOPA)
configuration seeding with a diode laser at a programmed pulse
duration of ∼250ns . The fiber amplifier successfully
demonstrates the pulse with 21.4 mJ at the repetition rate of 50 kHz
and a maximum average output power of 1535 W with a
slope efficiency of 81.6% at 250 kHz. To overcome fiber nonlinearities
such as stimulated Raman scattering (SRS) and self-phase modulation
(SPM), extra-large mode area ytterbium (Yb)-doped step-index dual
cladding fiber has been utilized as gain fiber in the MOPA laser
system. The gain saturation effect in the power amplifier was greatly
mitigated by the programmed seed signal. This pulse-shaped MOPA system
can provide practical applications in many fields such as laser
cleaning, paint stripping, and other applications requiring special
pulse shapes.
High-efficiency broadband fiber-to-chip coupler using a 3D nanoprinting microfiber
Authors: Fan Dong-Hui , Zhang Xing-Yu , Zhang Wei-Jun , Ma Ruo-Yan , Xiong Jia-Min , Wang Yu-Ze , Chen Zhi-Gang , Wang Zhen , You Li-Xing 
Published: May 2023

We propose a method for coupling a tapered optical fiber to an inverted tapered SiN waveguide by fabricating a microfiber using 3D nanoprinting lithography. The microfiber consists of three parts: a tapered cladding cap, an S-bend, and a straight part, all composed of high-refractive-index material. Light is adiabatically coupled from the tapered fiber to the printed microfiber through the cladding cap. The light is then transmitted through the S-bend and the straight part with low loss and is finally coupled to the waveguide through the evanescent field. In the simulation, our design can achieve a high coupling efficiency (TE mode) of ∼97% at a wavelength of 1542 nm with a wide bandwidth of ∼768nm at the 1-dB cutoff criterion.
On the causes of gene-body methylation variation in Arabidopsis thaliana
Authors: Pisupati Rahul , Nizhynska Viktoria , Mollá Morales Almudena , Nordborg Magnus 
Published: May 2023

Gene-body methylation (gbM) refers to sparse CG methylation of coding regions, which is especially prominent in evolutionarily conserved house-keeping genes. It is found in both plants and animals, but is directly and stably (epigenetically) inherited over multiple generations in the former. Studies in Arabidopsis thaliana have demonstrated that plants originating from different parts of the world exhibit genome-wide differences in gbM, which could reflect direct selection on gbM, but which could also reflect an epigenetic memory of ancestral genetic and/or environmental factors.
Here we look for evidence of such factors in F2 plants resulting from a cross between a southern Swedish line with low gbM and a northern Swedish line with high gbM, grown at two different temperatures. Using bisulfite-sequencing data with nucleotide-level resolution on hundreds of individuals, we confirm that CG sites are either methylated (nearly 100% methylation across sampled cells) or unmethylated (approximately 0% methylation across sampled cells), and show that the higher level of gbM in the northern line is due to more sites being methylated. Furthermore, methylation variants almost always show Mendelian segregation, consistent with their being directly and stably inherited through meiosis.
To explore how the differences between the parental lines could have arisen, we focused on somatic deviations from the inherited state, distinguishing between gains (relative to the inherited 0% methylation) and losses (relative to the inherited 100% methylation) at each site in the F2 generation. We demonstrate that deviations predominantly affect sites that differ between the parental lines, consistent with these sites being more mutable. Gains and losses behave very differently in terms of the genomic distribution, and are influenced by the local chromatin state. We find clear evidence for different trans-acting genetic polymorphism affecting gains and losses, with those affecting gains showing strong environmental interactions (G×E). Direct effects of the environment were minimal.
In conclusion, we show that genetic and environmental factors can change gbM at a cellular level, and hypothesize that these factors can also lead to transgenerational differences between individuals via the inclusion of such changes in the zygote. If true, this could explain genographic pattern of gbM with selection, and would cast doubt on estimates of epimutation rates from inbred lines in constant environments.
Implementation strategies and outcomes of school-based programs for adolescent suicide prevention: A scoping review protocol
Authors: Vargas Belén , Martínez Pablo , Mac-Ginty Scarlett , Hoffmann Tamara , Martínez Vania 
Published: May 2023

Objective
This scoping review aims to identify and map the empirical literature on the implementation strategies and outcomes of school-based programs for adolescent suicide prevention (SBASP).

Introduction
School-based programs are preferred interventions for preventing suicide in adolescents, and their effectiveness has been well-systematized in several reviews. Implementation research is a growing field for prevention programs, making it possible to understand the nature of success or failure outcomes and maximize intervention benefits. However, there is a knowledge gap in the implementation research applied to adolescent suicide prevention in the educational context. We conduct a scoping review to provide the first overview of the scope of implementation research applied to adolescent suicide prevention programs in the school setting to know what implementation strategies and outcomes are reported by these programs and how they are evaluated.

Methods
The proposed scoping review will be conducted following six stages, including the definition of objectives. Studies must be empirical and address implementation strategies or implementation outcomes of school-based programs for adolescent suicide prevention. Studies that focused exclusively on clinical efficacy or effectiveness evaluation will be excluded. A preliminary search of PubMed was conducted to refine the initial search strings, followed by a final search of several other electronic databases. Finally, a gray literature search will identify unpublished literature and reduce location bias. There will be no limits to a specific date. Two independent reviewers will screen, select, and extract the retrieved records. The results will be presented using tabular forms and a narrative summary with attention to the review objectives and research questions and their implications for research and practice of school-based programs for adolescent suicide prevention.
Effect of ERCC1 polymorphisms on the response to platinum-based chemotherapy: A systematic review and meta-analysis based on Asian population
Authors: Wu Xiaoqing , Lu Wenping , Jiang Cuihong , Zhang Dongni , Zhang Weixuan , Cui Yongjia , Zhuo Zhili , Mei Heting , Wang Ya’nan , Zhang Mengfan , Chen Shuntai 
Published: May 2023

BackgroundPlatinum-based chemotherapy is one of the most common treatments for many cancers; however, the effect of chemotherapy varies from individual to individual. Excision repair cross complementation group 1 (ERCC1) is widely recognized as a key gene regulating nucleotide excision repair (NER) and is closely associated with platinum response. Many studies have yielded conflicting results regarding whether ERCC1 polymorphisms can affect the response to platinum and overall survival (OS). Therefore, it is necessary to perform a meta-analysis of patients with specific races and cancer types.MethodsEight databases (EMBASE, PubMed, Cochrane Library, Chinese National Knowledge Infrastructure, Scopus, VIP, China Biology Medicine disc and Wanfang databases) were searched. Results were expressed in terms of odds ratios (ORs), hazard ratios (HRs) and 95% CIs.ResultsIn this study, rs11615, rs2298881 and rs3212986 SNPs were studied. In the comparison between CT and TT on the response to platinum, esophageal cancer [I2= 0%, OR = 6.18, 95% CI(1.89,20.23), P = 0.003] and ovarian cancer [I2= 0%, OR = 4.94, 95% CI(2.21,11.04), P<0.001] showed that the rs11615 CT genotype predicted a better response. In the comparison between CC and TT, ovarian cancer [I2= 48.0%, OR = 6.15, 95% CI (2.56,14.29), P<0.001] indicated that the CC genotype predicted a better response. In the meta-analysis of OS, the CC genotype was related to longer OS than TT in ovarian cancer [TT vs CC: I2= 57.7%, HR = 1.71, 95% CI (1.18, 2.49), P<0.001].ConclusionThe ERCC1 rs11615 polymorphism was related to the response to platinum and OS, but the correlation is based on specific cancer types in the Asian population.
Exploring access to HIV-related services and programmatic gaps for Men having Sex with Men (MSM) in rural India- a qualitative study
Authors: Bangar Sampada , Mohan Uday , Kumar Sanjeev , Mahapatra Amarendra , Singh Shivendra Kumar , Kohli Rewa , Verma Archana , Katendra Tuman Lal , Rahane Girish , Shewale Suhas P. , Yenbhar Nayana , Verma Vinita , Saravanamurthy P. , George Bitra , Kushwaha Bhawani Singh , Das Chinmoyee , Rajan Shobini , Sahay Seema 
Published: May 2023

Background
Despite the Link Worker Scheme to address the HIV risk and vulnerabilities in rural areas, reaching out to unreached men having sex with men (MSM) remains a challenge in rural India. This study explored issues around health care access and programmatic gaps among MSM in rural settings of India.

Methods
We conducted eight Focused Group Discussions (FGDs), 20 Key Informant Interviews (KIIs), and 20 In-Depth Interviews (IDIs) in four rural sites in Maharashtra, Odisha, Madhya Pradesh, and Uttar Pradesh between November 2018 and September 2019. The data in the local language were audio-recorded, transcribed, and translated. Data were analyzed in NVivo version 11.0 software using the grounded theory approach.

Results
Primary barriers to health care access were lack of knowledge, myths and misconceptions, not having faith in the quality of services, program invisibility in a rural setting, and anticipated stigma at government health facilities. Government-targeted intervention services did not seem to be optimally advertised in rural areas as MSM showed a lack of information about it. Those who knew reported not accessing the available government facilities due to lack of ambient services, fear of the stigma transforming into fear of breach of confidentiality. One MSM from Odisha expressed, “…they get fear to go to the hospital because they know that hospital will not maintain confidentiality because they are local people. If society will know about them, then family life will be disturbed” [OR-R-KI-04]. Participants expressed the desire for services similar to those provided by the Accredited Social Health Activists (ASHA), frontline health workers for MSM.

Conclusion
Programme invisibility emerges as the most critical issue for rural and young MSM. Adolescent and panthis emerged as Hidden MSM and they need focused attention from the programme. The need for village-level workers such as ASHA specifically for the MSM population emerged. MSM-friendly health clinics would help to improve healthcare access in rural MSMs under Sexual and Reproductive Health Care.
Feasibility of tobacco cessation intervention at non-communicable diseases clinics: A qualitative study from a North Indian State
Authors: Bhatt Garima , Goel Sonu , Grover Sandeep , Medhi Bikash , Jaswal Nidhi , Gill Sandeep Singh , Singh Gurmandeep 
Published: May 2023

Background
One of the ’best buys’ for preventing Non-Communicable Diseases (NCDs) is to reduce tobacco use. The synergy scenario of NCDs with tobacco use necessitates converging interventions under two vertical programs to address co-morbidities and other collateral benefits. The current study was undertaken with an objective to ascertain the feasibility of integrating a tobacco cessation package into NCD clinics, especially from the perspective of healthcare providers, along with potential drivers and barriers impacting its implementation.

Methods
A disease-specific, patient-centric, and culturally-sensitive tobacco cessation intervention package was developed (published elsewhere) for the Health Care Providers (HCPs) and patients attending the NCD clinics of Punjab, India. The HCPs received training on how to deliver the package. Between January to April 2020, we conducted a total of 45 in-depth interviews [medical officers (n = 12), counselors (n = 13), program officers (n = 10), and nurses (n = 10)] within the trained cohort across various districts of Punjab until no new information emerged. The interview data wereanalyzed deductively based on six focus areas concerning feasibility studies (acceptability, demand, adaptation, practicality, implementation, and integration) using the 7- step Framework method of qualitative analysis and put under preset themes.

Results
The respondent’s Mean ± SD age was 39.2± 9.2 years, and years of service in the current position were 5.5 ± 3.7 years. The study participants emphasized the role of HCPs in cessation support (theme: appropriateness and suitability), use of motivational interviewing, 5A’s & 5R’s protocol learned during the training & tailoring the cessation advice (theme: actual use of intervention activities); preferred face-to-face counseling using regional images, metaphors, language, case vignettes in package (theme: the extent of delivery to intended participants). Besides, they also highlighted various roadblocks and facilitators during implementation at four levels, viz. HCP, facility, patient, and community (theme: barriers and favorable factors); suggested various adaptations to keep the HCPs motivated along with the development of integrated standard operating procedures (SOPs), digitalization of the intervention package, involvement of grassroots level workers (theme: modifications required); the establishment of an inter-programmatic referral system, and a strong politico-administrative commitment (theme: integrational perspectives).

Conclusion
The findings suggest that implementing a tobacco cessation intervention package through the existing NCD clinics is feasible, and it forges synergies to obtain mutual benefits. Therefore, an integrated approach at the primary & secondary levels needs to be adopted to strengthen the existing healthcare systems.
Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus
Authors: Koenig Michelle R. , Mitzey Ann M. , Morgan Terry K. , Zeng Xiankun , Simmons Heather A. , Mejia Andres , Leyva Jaimes Fernanda , Keding Logan T. , Crooks Chelsea M. , Weiler Andrea M. , Bohm Ellie K. , Aliota Matthew T. , Friedrich Thomas C. , Mohr Emma L. , Golos Thaddeus G. 
Published: May 2023

Background
Congenital Zika virus (ZIKV) infection can result in birth defects, including malformations in the fetal brain and visual system. There are two distinct genetic lineages of ZIKV: African and Asian. Asian-lineage ZIKVs have been associated with adverse pregnancy outcomes in humans; however, recent evidence from experimental models suggests that African-lineage viruses can also be vertically transmitted and cause fetal harm.

Methodology/Principal findings
To evaluate the pathway of vertical transmission of African-lineage ZIKV, we inoculated nine pregnant rhesus macaques (Macaca mulatta) subcutaneously with 44 plaque-forming units of a ZIKV strain from Senegal, (ZIKV-DAK). Dams were inoculated either at gestational day 30 or 45. Following maternal inoculation, pregnancies were surgically terminated seven or 14 days later and fetal and maternal-fetal interface tissues were collected and evaluated. Infection in the dams was evaluated via plasma viremia and neutralizing antibody titers pre- and post- ZIKV inoculation. All dams became productively infected and developed strong neutralizing antibody responses. ZIKV RNA was detected in maternal-fetal interface tissues (placenta, decidua, and fetal membranes) by RT-qPCR and in situ hybridization. In situ hybridization detected ZIKV predominantly in the decidua and revealed that the fetal membranes may play a role in ZIKV vertical transmission. Infectious ZIKV was detected in the amniotic fluid of three pregnancies and one fetus had ZIKV RNA detected in multiple tissues. No significant pathology was observed in any fetus; and ZIKV did not have a substantial effect on the placenta.

Conclusions/Significance
This study demonstrates that a very low dose of African-lineage ZIKV can be vertically transmitted to the macaque fetus during pregnancy. The low inoculating dose used in this study suggests a low minimal infectious dose for rhesus macaques. Vertical transmission with a low dose in macaques further supports the high epidemic potential of African ZIKV strains.