bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment: Protocol for a Pilot Intervention Study
Authors: Ramdeo Karishma R , Fahnestock Margaret , Gibala Martin , Selvaganapathy Ponnambalam Ravi , Lee Justin , Nelson Aimee Jennifer 
Published: September 2023

Background
Mild cognitive impairment (MCI) is a syndrome preceding more severe impairment characterized by dementia. MCI affects an estimated 15% to 20% of people older than 65 years. Nonpharmacological interventions including exercise are recommended as part of overall MCI management based on the positive effects of exercise on cognitive performance. Interval training involves brief intermittent bouts of exercise interspersed with short recovery periods. This type of exercise promotes cognitive improvement and can be performed in individuals with MCI. Synaptic plasticity can be assessed in vivo by the neurophysiological response to repetitive transcranial magnetic stimulation (rTMS). A method to assess synaptic plasticity uses an intermittent theta burst stimulation (iTBS), which is a patterned form of rTMS. Individuals with MCI have decreased responses to iTBS, reflecting reduced synaptic plasticity. It is unknown whether interval training causes changes in synaptic plasticity in individuals living with MCI.

Objective
This research will determine whether interval training performed using a cycle ergometer enhances synaptic plasticity in individuals with MCI. The three aims are to (1) quantify synaptic plasticity after interval training performed at a self-determined intensity in individuals with MCI; (2) determine whether changes in synaptic plasticity correlate with changes in serum brain-derived neurotrophic factor, osteocalcin, and cognition; and (3) assess participant compliance to the exercise schedule.

Methods
24 individuals diagnosed with MCI will be recruited for assignment to 1 of the 2 equally sized groups: exercise and no exercise. The exercise group will perform exercise 3 times per week for 4 weeks. Synaptic plasticity will be measured before and following the 4-week intervention. At these time points, synaptic plasticity will be measured as the response to single-pulse TMS, reflected as the percent change in the average amplitude of 20 motor-evoked potentials before and after an iTBS rTMS protocol, which is used to induce synaptic plasticity. In addition, individuals will complete a battery of cognitive assessments and provide a blood sample from the antecubital vein to determine serum brain-derived neurotrophic factor and osteocalcin.

Results
The study began in September 2023.

Conclusions
The proposed research is the first to assess whether synaptic plasticity is enhanced after exercise training in individuals with MCI. If exercise does indeed modify synaptic plasticity, this will create a new avenue by which we can study and manipulate neural plasticity in these individuals.

Trial Registration
ClinicalTrials.gov NCT05663918; https://clinicaltrials.gov/study/NCT05663918

International Registered Report Identifier (IRRID)
PRR1-10.2196/50030
The Effectiveness of Video-Based Game Exercise Therapy Applications in Pes Planus Rehabilitation: Protocol for a Randomized Controlled Trial
Authors: Erten Ayşe Büşra , Tarakçı Devrim , Çaçan Mehmet Akif 
Published: September 2023

Background
Pes planus is one of the most common foot deformities. Although there are many studies on the effectiveness of various exercise methods in pes planus rehabilitation, the number of studies on video-based game exercise therapy applications is very limited.

Objective
This study aims to evaluate the effectiveness of 2 video-based game exercise therapies and structured exercise practices in pes planus rehabilitation.

Methods
This study is a 3-arm, parallel-group, single-blinded randomized controlled trial. The study will include 69 patients with flexible pes planus aged between 18 and 25 years who attend the orthopedics and traumatology clinic and meet the inclusion criteria. The primary outcomes are measures of navicular drop and pedobarographic analysis before and after the intervention, and the secondary outcomes include balance, femoral anteversion, and lower extremity muscle strength. Participants will be evaluated with a navicular drop test for medial longitudinal arch height, a pedobarographic analysis system for plantar pressure analysis, a Craig test for femoral anteversion, the Becure Balance System for balance measurement, and a myometer device for lower extremity muscle strength measurement. Participants will be randomly assigned to a structured exercise group, an exergame group, or a serious game group according to their order of arrival. The structured exercise group will use a short foot exercise, a towel-picking exercise, and various walking and balance exercises. Patients in the serious play group will play the lower extremity games in the Becure Balance System. Patients in the exergame group will play balance games on the Nintendo Wii game console. All participants will participate in 18 exercise sessions (3 days a week for 6 weeks). After the treatment, the initial measurements will be repeated.

Results
The study started in January 2023. It is expected to be completed in June 2024.

Conclusions
This study will be the first randomized controlled study to evaluate the effectiveness of 2 different video-based game exercise therapy applications in pes planus rehabilitation. Through this study, the use of video-based game exercise therapy in pes planus rehabilitation, together with the developing technology, will be a guide. In addition, a new exercise protocol, including serious game exercises, will be added to the literature. In the future, it is expected that our study on the development of different game systems, especially for the ankle, will provide pioneering feedback.

Trial Registration
ClinicalTrials.gov NCT05679219; https://clinicaltrials.gov/study/NCT05679219

International Registered Report Identifier (IRRID)
DERR1-10.2196/51772
Optimization of Counseling Services at the Desks to the Four Posyandu
Authors: Indrayani Novi 
Published: September 2023

During providing services Posyandu Lestari I and Ringinsari I only include anthropometric measurements in infants and toddlers, complementary breastfeeding, immunization, administration of Vitamin A and Deworming (February and August), while counseling services for mothers and toddlers of babies at the tables of four posyandu have not been implemented. Counseling at Posyandu will only be carried out when there are health workers who visit, which is usually only in February and August every year. The purpose of this community service is to improve the services provided by the posyandu, one of which is to reactivate the fourth table. The service at the fourth table is the service provided by the cadre in the form of counseling for infant and toddler mothers The method used in education on improving posyandu services is training on the use of posyandu backsheets to assist cadres in providing counseling at the fourth table of the posyandu. The result obtained from this Community Service is that there are differences in providing counseling before and after getting education on the use of backsheets for counseling at the desks of the four posyandu. Counseling services at the fourth table can increase the satisfaction of mothers of babies and toddlers in receiving services at posyandu.
Production of Graphene By Coconut Shell As an Electrode Primary Battery Cell
Authors: Pasaribu Elsa , Siburian Rikson , Supeno Minto 
Published: September 2023

Abstract: Coconut shells are a natural resource that contains a lot of carbon (C). The pyrolysis process can be used to create coconut shells. A single layer of carbon atoms that have undergone sp2 hybridization to form a hexagonal, two-dimensional structure is known as Graphene. Graphene has excellent potential for battery manufacturing applications, supercapacitors, etc. Activated carbon and the pyrolisis method of producing Graphene were combined and heated to 600 oC for one hour. The graphene generated is assessed using an XRD, SEM-EDX, TEM, Raman, and conductometer. The results of the X-ray diffractogram analysis revealed that the peaks at 2θ = 23,87o and 44,5o are not particularly sharp and slightly broadened. It means Graphene are well formed. SEM-EDX investigation reveals that the surface size and shape structure is smaller and thinner, a flat pile dominated by carbon atoms. The result of conductometer analysis shows the electrical conductivity of Graphene is quite good, but Graphene can still not control the movement of electrons. Graphene has layer distances between Graphene and Graphene layers are 3.3 Å (TEM data), with many Graphene layers being 0.85 (multi-layer) (Raman data).Abstrak: Batok kelapa merupakan salah satu sumber daya alam yang mengandung banyak karbon (C). Proses pirolisis dapat digunakan untuk membuat batok kelapa. Satu lapisan atom karbon yang telah mengalami hibridisasi sp2 untuk membentuk struktur dua dimensi heksagonal dikenal sebagai Grafena. Grafena memiliki potensi besar untuk aplikasi pembuatan baterai, superkapitasitor, dan sebagainya. Karbon aktif dengan metode pirolisis untuk memproduksi Grafena dipanaskan hingga 600 oC selama satu jam. Grafena yang dihasilkan dikarakterisasi menggunakan XRD, SEM-EDX, TEM, Raman, and Konductometer. Hasil analisis difraktogram sinar-X mengungkapkan bahwa puncak pada 2θ = 24,22o dan 44o tidak terlalu tajam dan sedikit melebar. Ini berarti Grafena terbentuk dengan baik. Analisis SEM-EDX mengungkapkan bahwa ukuran permukaan dan struktur bentuk lebih kecil dan lebih tipis dan itu adalah tumpukan datar yang didominasi oleh atom karbon. Hasil analisis konduktometer menunjukkan konduktivitas listrik Grafena cukup baik, namun Grafena masih belum mampu mengontrol pergerakan elektron. Grafena memiliki jarak lapisan antara lapisan Grafena dan Grafena adalah 3,3 Å (data TEM) dengan jumlah lapisan Grafena adalah 0,85 (multilapisan) (data Raman).
Insights from very Large Ensemble Data Assimilation Experiments with a High Resolution General circulation model of the Red Sea
Authors: sanikommu sivareddy , Raboudi Naila , Gharamti Mohamad , Zhan Peng , Hadri Bilel , Hoteit Ibrahim 
Published: September 2023

Ensemble Kalman Filters (EnKFs), which assimilate observations based on
statistics derived from samples of ocean states called ensemble, have
become the norm for ocean data assimilation (DA) and forecasting. These
schemes are commonly implemented with inflation and localization
techniques to increase their ensemble spread and to filter out spurious
long-range correlations resulting from the limited-size ensembles
imposed by computational burden constraints. Such ad hoc methods were
found not necessary in ensemble DA experiments with simplified
ocean/atmospheric models and large ensembles. Here, we conduct a series
of 1-year-long ensemble experiments with a fully realistic EnKF-DA
system in the Red Sea using tens-to-thousands of ensemble members. The
system assimilates satellite and in-situ observations and accounts for
model uncertainties by integrating a 4km-resolution ocean model with
ECMWF atmospheric ensemble fields, perturbed internal physics and
initial conditions for forecasting.
Our results indicate that accounting for model uncertainties is more
beneficial than simply increasing the ensemble size, with the
improvements due to large ensemble leveling off at about 250 members.
Besides, and in contrast to what is commonly observed with simplified
models, the investigated ensemble DA system still required localization
even when implemented with thousands of members. These findings are
explained by (i) amplified spurious long-range correlations produced by
the low-rank nature of the ECMWF atmospheric forcing ensemble, and (ii)
non-Gaussianity generated by the perturbed internal physical
parameterization schemes. Large ensemble forcing fields and non-Gaussian
DA methods might be needed to take full benefits from large ensembles in
ocean DA.
Does Investment Bankers’ Prior Experience in Public Accounting Reduce Earnings Management in IPO Firms?
Authors: He Xianjie , Pittman Jeffrey , Stein Sarah E. , Yin Huifang 
Published: September 2023

SUMMARY
We examine whether firms undertaking an initial public offering (IPO) exhibit less earnings management when individual investment bankers have prior experience in public accounting. Although auditors are primarily responsible for providing external monitoring of the financial reporting process, individual bankers also have strong incentives to improve accounting quality in firms going public. We predict a negative relation between public accounting experience and IPO firms’ earnings management because working in public practice fosters individual bankers’ accounting expertise and conservative personalities. In exploiting unique disclosures of investment bankers’ identities and characteristics in China, our analysis indicates that bankers with early-career public accounting experience constrain IPO firms’ accrual-based earnings management. Consistent with expectations, we find that this evidence is more pronounced if the accounting firm that employed the future investment banker is larger, is permitted to audit listed companies, and was previously subject to a regulatory sanction.
Data Availability: Most data are publicly available from the sources identified in the paper. Hand-collected data from the Securities Association of China (SAC) can be made available upon request.
JEL Classifications: G24; M41; M42.
Opportunities or Challenges? Audit Risk and Blockchain Disclosures in 10-K Filings
Authors: Huang Feiqi , Wang Tawei , Yen Ju-Chun 
Published: September 2023

SUMMARY
This study investigates whether audit clients’ blockchain activities (including crypto-related activities) affect audit risk by examining the association between blockchain disclosures in 10-K filings and audit fees. Focusing on U.S. firms between 2013 and 2020, we empirically show that audit fees are higher for companies disclosing blockchain activities in 10-K filings. We further find that this positive association is more pronounced for companies disclosing current blockchain implementation than for companies with plans for blockchain activities. The results indicate that clients’ blockchain activities influence audit risk as assessed by external auditors. As blockchain technology and its applications are emerging, our findings have implications that should be considered by auditors, regulators, and top management.
Interacciones medicamentosas
Authors: Velasco Martín Alfonso , Velasco Sendra María 
Published: September 2023

La terapéutica antigua empleaba con mucha frecuencia en una receta asociaciones tan complejas que difícilmente se podía adivinar el efecto que de ellas podía obtenerse, presentándose además interacciones medicamentosas muy peligrosas. En los comienzos de nuestro siglo vino una reacción en contra de esta absurda polifarmacia. Huchard, en 1909, decía: “Aconsejo no emplear a la vez más que un solo medicamento, sea alcaloide o glicósido, cuya acción fisiológica y terapéutica os sea bien conocida… Desconfiad de las asociaciones medicamentosas, que pueden contrariar la acción fisiológica y terapéutica, que son aún capaces de producir mezclas muy similares e inútiles, cuando no peligrosas”. Las interacciones medicamentosas pueden clasificarse en: interacciones fuera del organismo (incompatibilidades físicas y químicas), interacciones farmacocinéticas, interacciones farmacodinámicas y terapéuticas, interacciones nutrientes-medicamentos.
Esplenomegalia como signo de enfermedad lisosomal
Authors: García Frade Luis Javier , Campano García Ana , Villarubia J 
Published: September 2023

La estructura sana del bazo funciona como función hematopoyética para el período fetal; después, se convierte en un gran órgano linfoide, y también, es del sistema de filtro de células sanguíneas.
La enfermedad de Gaucher es un extraño trastorno de almacenamiento lisosomal, muchos de ellos son hereditarios y multisistémicos. Hoy en día, setenta LSD han sido adoptados.
Risk of incident pericarditis after coronavirus disease 2019 recovery: a systematic review and meta-analysis
Authors: Zuin Marco , Imazio Massimo , Rigatelli Gianluca , Pasquetto Giampaolo , Bilato Claudio 
Published: September 2023

AimsData regarding the risk of incident pericarditis in coronavirus disease 2019 (COVID-19) recovered patients are lacking. We determined the risk of incident pericarditis after COVID-19 infection by performing a systematic review and meta-analysis of available data.MethodsFollowing the PRISMA guidelines, we searched MEDLINE and Scopus to locate all articles published up to 11 February 2023 reporting the risk of incident pericarditis in patients who had recovered from COVID-19 infection compared to noninfected patients (controls) defined as those who did not experience the disease over the same follow-up period. Pericarditis risk was evaluated using the Mantel–Haenszel random effects models with hazard ratio (HR) as the effect measure with 95% confidence interval (CI) while heterogeneity was assessed using HigginsI2statistic.ResultsOverall, 16 412 495 patients (mean age 55.1 years, 76.8% males), of whom 1 225 715 had COVID-19 infection, were included. Over a mean follow-up of 9.6 months, pericarditis occurred in 3.40 (95% CI: 3.39–3.41) out of 1000 patients who survived COVID-19 infection compared with 0.82 (95% CI: 0.80–0.83) out of 1000 control patients. Recovered COVID-19 patients presented a higher risk of incident pericarditis (HR: 1.95, 95% CI: 1.56–2.43,I2: 71.1%) compared with controls. Meta-regression analysis showed a significant direct relationship for the risk of incident pericarditis using HT (P = 0.02) and male sex (P = 0.02) as moderators, while an indirect association was observed when age (P = 0.01) and the follow-up length (P = 0.02) were adopted as moderating variables.ConclusionsRecovered COVID-19 patients have a higher risk of pericarditis compared with patients from the general population.
Comparative assessment of deterministic methodologies for estimating excavation productivity
Authors: Panas Antonios , Pantouvakis John-Paris , Kalogiannaki Maria 
Published: September 2023

Abstract
This paper investigates the prediction capability of deterministic methodologies in estimating construction productivity for earthmoving operations. Published literature includes several estimation methodologies stemming from (a) equipment manufacturers’ manuals, (b) editions from German contractors’ associations or individual researchers and (c) textbook editions. The purpose of this research is to assess the yielded productivity estimation results under the prism of 14 estimation methodologies. It is – to the authors’ best knowledge – the first research attempt for the comparative evaluation of such a diverse set of estimation methodologies, with the aim of quantifying their effects on the operations analysis in earthmoving works. A uniform mathematical modelling approach is used to formulate the relevant estimation equations and, subsequently, a real-case scenario of an earthmoving project in Greece is used as a benchmark against which the robustness of each methodology is assessed. A sensitivity analysis on main productivity factors concludes the research. The preliminary results indicate that equipment manufacturers’ methods are more optimistic and present higher sensitivity to specific productivity factors (e.g. swing angle, excavation depth), whereas the German-oriented approaches are more conservative with less variability due to differing productivity factors.
A competency framework for strategic planning managers in multi-business holding organisations
Authors: Ershadi Mahmoud , Moghaddam Mohammad Rahimi , Ezabadi Mohammad Ebrahim Raei 
Published: September 2023

Abstract
Nowadays, the business environment is dynamic and constantly changing, which intensifies competition among companies. The complexity of competition in multi-business holding companies is higher than in other organisations due to the complexities of different industries and their uncertainties in terms of investment policies and corporate strategies. Such companies need a strategic plan to align business requirements with their various functions. In this regard, strategic planning managers (SPMs) have a significant role in analysing possible business scenarios and putting optimal plans in place to guarantee their implementation in a specific timeline. This study aims to identify and discuss the necessary competencies and capabilities of this cohort of managers. In the present article, a qualitative approach was adopted, and the findings are based on observations in a case study multi-discipline holding organisation. The viewpoints of the key managers were obtained, and a competency framework was developed. The results indicate that the professional competencies of SPMs can be explained in terms of the two aspects of (1) strategy formulation and (2) strategy implementation. A framework is presented in this paper that summarises the viewpoints of managers in the case study organisation on the requisite competencies of SPMs. Although prior studies explain the general competencies of managers from a universal perspective, this study steps beyond the borders of such models and extends the literature on the professional competencies of a specific and most influential cohort of business managers in holding organisations through an in-depth case study.
Estrategias pedagógicas para fortalecer los indicadores de inclusión en la Institución Educativa El Carmelo
Authors: Arroyo Cervera Luis Fernando , Liscano Caldón Patricia Fernanda , Granada Robles Jefferson 
Published: September 2023

En la actualidad se hace necesaria la implementación de políticas inclusivas que permitan el libre acceso a educación de calidad a niños, niñas y jóvenes con necesidades educativas, con personal docente alta y medianamente capacitado para solventar dichas necesidades y así proponer, mediante prácticas educativas dinamizadoras, la generación de espacios de aprendizaje donde primen la diversidad, la creatividad y el respeto por la otredad; espacios donde se dignifique el ser para que el quehacer de estas comunidades, particularmente de aquellas en zonas rurales, se potencie y logre así conseguir la tan anhelada trasformación social que se necesita en la región.
En este artículo presentamos una aproximación a un sistema de indicadores para la medición, evaluación, y resignificación de la inclusión en el Plan Educativo Institucional de la Institución Educativa El Carmelo en el municipio de La Plata en el departamento del Huila, orientado a maximizar las ya consolidadas prácticas pedagógicas incluyentes que se vienen llevando a cabo a lo largo de estos años. Se desglosarán los indicadores que permiten entender cada componente del índice y se dará una explicación certera sobre la situación de la institución en materia de estrategias, planes, herramientas, metodologías y demás, que estén subsanando la brecha educativa en la población con NEE a través de la implementación de Planes Individuales de Ajustes Razonables (PIAR) y el Diseño Universal de Aprendizaje (DUA). Finalmente, se corresponderán los objetivos específicos y el general con la discusión y las conclusiones, enunciando las posibles líneas investigativas que pueden surgir a partir de este trabajo de investigación.
Dia mundial da pessoa com esquizofrenia: saiba mais sobre a doença
Authors: Loch Alexandre Andrade , Minervino Alfredo José , Valiengo Leandro da Costa Lane 
Published: September 2023

A esquizofrenia é uma doença mental crônica que geralmente se manifesta na adolescência ou início da vida adulta. Segundo dados da Organização Mundial de Saúde - OMS, a esquizofrenia é a terceira causa de perda da qualidade de vida entre os 15 e 44 anos. São cerca de 1,6 milhão de brasileiros que, além da doença, precisam lidar com o preconceito. Quais são os principais sintomas da esquizofrenia? O que causa a doença? A prevalência é maior em homens ou mulheres?