bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital Catchment Areas Characteristics and Geographic Regions Associated With Higher COVID-19 Veterans Health Administration Hospitalization During the Omicron Surge
Authors: Wong Michelle S. , Frochen Stephen , Steers W. Neil , Washington Donna L. 
Published: April 2023

Context:
Surges in the ongoing coronavirus-19 (COVID-19) pandemic and accompanying increases in hospitalizations continue to strain hospital systems. Identifying hospital-level characteristics associated with COVID-19 hospitalization rates and clusters of hospitalization “hot spots” can help with hospital system planning and resource allocation.

Objective:
To identify (1) hospital catchment area–level characteristics associated with higher COVID-19 hospitalization rates and (2) geographic regions with high and low COVID-19 hospitalization rates across catchment areas during COVID-19 Omicron surge (December 20, 2021-April 3, 2022).

Design:
This observational study used Veterans Health Administration (VHA), US Health Resource & Services Administration's Area Health Resources File, and US Census data. We used multivariate regression to identified hospital catchment area–level characteristics associated with COVID-19 hospitalization rates. We used ESRI ArcMap's Getis-Ord Gi* statistic to identify catchment area clusters of hospitalization hot and cold spots.

Setting and Participants:
VHA hospital catchment areas in the United States (n = 143).

Main Outcome Measures:
Hospitalization rate.

Results:
Greater COVID-19 hospitalization was associated with serving more high hospitalization risk patients (34.2 hospitalizations/10 000 patients per 10-percentage point increase in high hospitalization risk patients; 95% confidence intervals [CI]: 29.4, 39.0), fewer patients new to VHA during the pandemic (−3.9, 95% CI: −6.2, −1.6), and fewer COVID vaccine-boosted patients (−5.2; 95% CI: −7.9, −2.5).
We identified 2 hospitalization cold spots located in the Pacific Northwest and in the Great Lakes regions, and 2 hot spots in the Great Plains and Southeastern US regions.

Conclusions:
Within VHA's nationally integrated health care system, catchment areas serving a larger high hospitalization risk patient population were associated with more Omicron-related hospitalizations, while serving more patients fully vaccinated and boosted for COVID-19 and new VHA users were associated with lower hospitalization. Hospital and health care system efforts to vaccinate patients, particularly high-risk patients, can potentially safeguard against pandemic surges.
Hospitalization hot spots within VHA include states with a high burden of chronic disease in the Great Plains and Southeastern United States.
Core stabilization exercise in prenatal and postnatal women with urinary incontinence: A systematic review and meta-analysis of randomized controlled trials
Authors: Yu Chin-Yin , Yu Tzu-Yin , Chen Yi-Wen , Lin Li-Fong , Peng Chih-Wei , Chen Hung-Chou 
Published: April 2023

Abstract

Objective
To evaluate the effect size of core stabilization exercise for prenatal and postnatal women through measures of urinary symptoms, voiding function, pelvic floor muscle strength and endurance, quality of life, and pain scores.

Design
The PubMed, EMBASE, Cochrane Library, and Scopus databases were searched. Randomized controlled trials were selected and subjected to meta-analysis and risk of bias assessment.

Results
Ten Randomized controlled trials were selected, and 720 participants were included. Ten articles using seven outcomes were analyzed. Relative to the control groups, the core stabilization exercise groups exhibited superior results for urinary symptoms (standardized mean difference [SMD] = −0.65, 95% confidence interval [CI] = −0.97–0.33), pelvic floor muscle strength (SMD = 0.96, 95% CI = 0.53,1.39), pelvic floor muscle endurance (SMD = 0.71, 95% CI = 0.26,1.16), quality of life (SMD = −0.9, 95% CI = −1.23–0.58), transverse muscle strength (SMD = −0.45, 95% CI = −0.9,–0.01), and voiding function (SMD = −1.07, 95% CI = −1.87–0.28).

Conclusion
Core stabilization exercises are safe and beneficial for alleviating urinary symptoms, improving quality of life, strengthening pelvic floor muscles, and improving transverse muscle function in prenatal and postnatal women with urinary incontinence.
Analysis of side effects of cryoneurolysis for the treatment of spasticity
Authors: Winston Paul , MacRae Fraser , Rajapakshe Shanika , Morrissey Isabella , Boissonnault Ève , Vincent Daniel , Hashemi Mahdis 
Published: April 2023

AbstractObjectiveTo report side effects from clinical studies on ultrasound-guided percutaneous cryoneurolysis for spasticity.DesignPatients were prospectively enrolled in three studies at a single institution. Cryoneurolysis was performed to primarily motor nerve branches (medial and lateral pectoral, musculocutaneous, radial, median, ulnar, tibial, obturator) and mixed motor sensory nerve trunks (median, ulnar, suprascapular, radial, and tibial).ResultsCryoneurolysis was performed for 277 nerves (99 mixed motor sensory), on 113 patients (59F, 54 M, average age 54.4 years). One patient had a local skin infection, two patients had bruising or swelling; all resolved within one month. 9 reported nerve pain or dysesthesia (two motor, seven mixed motor sensory nerves). Four received no treatment, four oral or topical medications, two perineural injections, one botulinum toxin. Three patients' symptoms remained until three months, one had numbness at six. One patient had botulinum toxin injections for cramping. All had at minimum three months follow-up; seven withdrew (x̄ = 5.4 months), four passed away. None of these eleven reported side effects.Conclusions96.75% of nerve treatments had no pain or dysesthesias beyond treatment. Few had pain or numbness beyond three months. Cryoneurolysis has potential to be a safe spasticity treatment with manageable side effects.
Superimposition Study to Determine the Angular Arterial Distribution and its Clinical Application
Authors: Shin Hyun Jin , Kim Hee-Jin , Song Wu-Chul 
Published: April 2023

Purpose:
To determine the distribution of the angular artery (AA) in the medial canthal area with the aim of defining an arterial course to prevent AA injury during facial surgery in this region.

Methods:
We dissected 36 hemifaces of 18 cadavers. The horizontal distance from the vertical level through the medial canthus to the AAs was measured. The AA course of each specimen was then recorded, and all of them were then superimposed to determine the AA course. The diameter and depth of the AA around the medial canthal area were also investigated using ultrasonography on living subjects.

Results:
The horizontal distances from the medial canthus level and 2 cm below the medial canthus were 9.0±2.0 mm (mean±standard deviation) and 1.9±2.4 mm, respectively. The superimposed image demonstrated that most of the AAs were present inside the vertical line through the medial canthus. Ultrasonography indicated that the AA was 2.3±0.9 mm below the skin and 1.7±0.3 mm in diameter.

Conclusions:
The AA course was relatively constant along the nasojugal fold. The AAs were most often present between the middle of the medial canthus and the facial midline, but were very scarce in both the medial and lateral thirds. Knowledge of the detailed course of the AA may help surgeons to avoid arterial injury and decrease the risk of surgical morbidities around the nasal root and medial canthal area.

Levels of Evidence:
Basic science and clinical study
Transcriptomics in serum and culture medium reveal shared and differential gene regulation in pathogenic and commensal Streptococcus suis
Authors: Fredriksen Simen , Ruijten Suzanne D. E. , Murray Gemma G. R. , Juanpere-Borràs Maria , van Baarlen Peter , Boekhorst Jos , Wells Jerry M. 
Published: April 2023

Streptococcus suis

colonizes the upper respiratory tract of healthy pigs at high abundance but can also cause opportunistic respiratory and systemic disease. Disease-associated

S. suis

reference strains are well studied, but less is known about commensal lineages. It is not known what mechanisms enable some

S. suis

lineages to cause disease while others persist as commensal colonizers, or to what extent gene expression in disease-associated and commensal lineages diverge. In this study we compared the transcriptomes of 21

S

.

suis

strains grown in active porcine serum and Todd–Hewitt yeast broth. These strains included both commensal and pathogenic strains, including several strains of sequence type (ST) 1, which is responsible for most cases of human disease and is considered to be the most pathogenic

S. suis

lineage. We sampled the strains during their exponential growth phase and mapped RNA sequencing reads to the corresponding strain genomes. We found that the transcriptomes of pathogenic and commensal strains with large genomic divergence were unexpectedly conserved when grown in active porcine serum, but that regulation and expression of key pathways varied. Notably, we observed strong variation of expression across media of genes involved in capsule production in pathogens, and of the agmatine deiminase system in commensals. ST1 strains displayed large differences in gene expression between the two media compared to strains from other clades. Their capacity to regulate gene expression across different environmental conditions may be key to their success as zoonotic pathogens.
Structure-Property-Processing Correlations of Graphene Bioscaffolds for Proliferation and Differentiation of C2C12 Cells
Authors: Karriem Lynn , Eixenberger Joshua , Frahs Stephanie , Convertino Domenica , Webb Tyler , Pandhi Twinkle , McLaughlin Kari , Enrriques Ashton , Davis Paul , Subbaraman Harish , Colletti Camilla , Oxford Julia T. , Estrada David 
Published: April 2023

AbstractGraphene – an atomically thin layer of carbon atoms arranged in a hexagonal lattice – has gained interest as a bioscaffold for tissue engineering due to its exceptional mechanical, electrical, and thermal properties. Graphene’s structure and properties are tightly coupled to synthesis and processing conditions, yet their influence on biomolecular interactions at the graphene-cell interface remains unclear. In this study, C2C12 cells were grown on graphene bioscaffolds with specific structure–property– processing–performance (SP3) correlations. Bioscaffolds were prepared using three different methods - chemical vapor deposition (CVD), sublimation of silicon carbide (SiC), and printing of liquid phase exfoliated graphene. To investigate the biocompatibility of each scaffold, cellular morphology and gene expression patterns were investigated using the bipotential mouse C2C12 cell line. Using a combination of fluorescence microscopy and qRT-PCR, we demonstrate that graphene production methods determine the structural and mechanical properties of the resulting bioscaffold, which in turn determine cell morphology, gene expression patterns, and cell differentiation fate. Therefore, production methods and resultant structure and properties of graphene bioscaffolds must be chosen carefully when considering graphene as a bioscaffold for musculoskeletal tissue engineering.
Functional specialization of hippocampal somatostatin-expressing interneurons
Authors: Chamberland Simon , Grant Gariel , Machold Robert , Nebet Erica R. , Tian Guoling , Hanani Monica , Kullander Klas , Tsien Richard W. 
Published: April 2023

AbstractHippocampal somatostatin-expressing (Sst) GABAergic interneurons (INs) exhibit considerable anatomical and functional heterogeneity. Recent single cell transcriptome analyses have provided a comprehensiveSst-IN subtype census, a plausible molecular ground truth of neuronal identity whose links to specific functionality remain incomplete. Here, we designed an approach to identify and access subpopulations ofSst-INs based on transcriptomic features. Four mouse models based on single or combinatorial Cre- and Flp- expression differentiated functionally distinct subpopulations of CA1 hippocampalSst-INs that largely tiled the morpho-functional parameter space of theSst-INs superfamily. Notably, theSst;;Tac1intersection revealed a population of bistratified INs that preferentially synapsed onto fast-spiking interneurons (FS-INs) and were both necessary and sufficient to interrupt their firing. In contrast, theNdnf;;Nkx2-1intersection identified a population of oriens lacunosum-moleculare (OLM) INs that predominantly targeted CA1 pyramidal neurons, avoiding FS-INs. Overall, our results provide a framework to translate neuronal transcriptomic identity into discrete functional subtypes that capture the diverse specializations of hippocampalSst-INs.Significance statementGABAergic interneurons are important regulators of neuronal activity. Recent transcriptome analyses have provided a comprehensive classification of interneuron subtypes, but the connections between molecular identities and specific functions are not yet fully understood. Here, we developed an approach to identify and access subpopulations of interneurons based on features predicted by transcriptomic analysis. Functional investigation in transgenic animals revealed that hippocampal somatostatin-expressing interneurons (Sst-INs) can be divided into at least four subfamilies, each with distinct functions. Most importantly, theSst;;Tac1intersection targeted a population of bistratified cells that overwhelmingly targeted fast-spiking interneurons. In contrast, theNdnf;;Nkx2-1intersection revealed a population of oriens lacunosum-moleculare interneurons that selectively targeted CA1 pyramidal cells. Overall, this study reveals that genetically distinct subfamilies ofSst-INs form specialized circuits in the hippocampus with differing functional impact.
Research developments in sustainable supply chain management considering optimization and industry 4.0 techniques: a systematic review
Authors: Detwal Pankaj Kumar , Agrawal Rajat , Samadhiya Ashutosh , Kumar Anil , Garza-Reyes Jose Arturo 
Published: April 2023

PurposeThe literature that is presently available on sustainable supply chain management (SSCM) combining optimization and industry 4.0 techniques falls short in its depictions of the recent developments, budding pertinent areas and the importance of SSCM in the growth of industrial economies around the world. This article's main objective is to analyze current trends, highlight the latest initiatives and perform a meta-analysis of the literature that is currently accessible in the SSCM area with a special focus on optimization and industry 4.0 techniques. The paper also proposes a conceptual framework that will assist in illuminating how the ideas of optimization and industry 4.0 may contribute to realizing sustainability in supply chains.Design/methodology/approachThe proposed study systematically reviews 85 research publications published between 2010 and 2022 in referenced peer-reviewed journals in diverse fields, including engineering, business and management, services and healthcare. Numerous categories are considered throughout the examination of the literature, including year-wise publications, prominent journals, type of research design, concerned industry and research technique used.FindingsThe study demonstrates a deeper comprehension of the literature in the field and its evolution throughout numerous industry sectors, which is helpful for both practitioners and academics. The results from the content analysis highlight various future research opportunities in the domain.Originality/valueThis is one of the first research articles that have attempted to establish, analyze and highlight the current trends and initiatives in the SSCM domain from an optimization and industry 4.0 techniques viewpoint. The cluster-based future research propositions also enhance the novelty of the study.
Why are not men and women more alike? Gender and clawbacks in the trade-off between accrual and real activity earnings manipulation
Authors: Sari Ratna Candra , Sholihin Mahfud , Zuhrohtun Zuhrohtun , Purnama Ida Ayu , Dewanti Patriani Wahyu , Udhma Umi Syafaatul 
Published: April 2023

Purpose
The purpose of this study is to examine the trade-off between accrual and real activity earnings manipulation by considering gender and punishment as one aspect of clawbacks.

Design/methodology/approach
To achieve the research objectives, experimental design research was used, involving 183 professional accountants in Indonesia. This was followed by interviews with board members of public companies in Indonesia.

Findings
After the adoption of clawbacks, the intention to manipulate accruals decreased more among women than among men. However, the possible unintended consequences of clawbacks, particularly an increase in real activity manipulation, did not differ between women and men.

Originality/value
There are still few studies that use experimental designs to examine the consequences of clawback. Our study is expected to provide a novel contribution to the literature on the consequences of clawbacks as we use an experimental method. Besides, previous research that tested the consequences of clawback, using both archival and experimental data, had not considered the gender aspect, thus prompting this study to fill the research gap related to the consequences of clawback adoption by including the gender variable.
Employee culture of health perceptions and the development of a training intervention
Authors: Farris Kristen L. , Burns Michael E. , Burke Tricia J. , Bezner Janet R. 
Published: April 2023

PurposeThe authors used a case study approach to explore employees' perceptions of one institution's culture of health. The authors then applied a needs-centered training model to create and test the effectiveness of a workplace wellness training program to improve the culture of health.Design/methodology/approachFor study 1, the authors recruited 736 faculty and staff from an institution of higher education to complete an online culture of health survey measuring their perceived leadership support, peer support and institutional resources. In study 2, participants (n = 60) in follow-up focus groups described their experiences related to the culture of health at the institution. For study 3, university employees (n = 44) participated in the training intervention and reported on post-test outcomes measuring the training's effectiveness.FindingsHigh levels of employee stress and lack of supervisor and coworker support were identified as significant issues in the needs assessment process. Therefore, the authors developed a needs-centered training intervention that focused on supportive and confirming supervisor and peer communication. Results suggest employees perceive the training to be effective, are ready to change their behaviors and are knowledgeable about the training content.Originality/valueThis study provides evidence regarding needs-based trainings focused on co-worker communication and how these trainings may incrementally improve the culture of health within organizations. Accordingly, the authors offer best practices, including the value of focusing on employee needs, advocating for employees, building community through trainings and enacting change through the training process.
Factors influencing Muslim Generation Z consumers’ purchase intention of environmentally friendly halal cosmetic products
Authors: Irfany Mohammad Iqbal , Khairunnisa Yusniar , Tieman Marco 
Published: April 2023

Purpose
This study aims to identify the characteristics of Muslim Generation Z and analyze the factors that influence its purchase intention of environmentally friendly halal cosmetic products.

Design/methodology/approach
This research adopts the quantitative methods of a questionnaire and sampling technique using purposive sampling. The respondents in this study were 300 Indonesian Muslims from Generation Z. Descriptive analysis and structural equation modeling–partial least structural with SmartPLS 3.3.7 software were used to analyze the research data.

Findings
This study found that of the nine hypotheses tested, seven are confirmed, including the effect of halal labels on halal-green awareness, environmentally friendly labels on halal-green awareness, environmental knowledge on halal-green awareness and knowledge on attitudes. Meanwhile, religiosity and halal-green awareness influence attitudes and attitudes that affect the purchase intention of environmentally friendly halal cosmetics. Two hypotheses that are not accepted are the influence of religiosity on halal-green awareness and halal-green awareness on attitudes. The findings are expected to increase interest in buying environmentally friendly halal cosmetics by better understanding consumer behavior, especially Generation Z.

Practical implications
Cosmetics manufacturers benefit from halal-green branding on their products to enter new halal markets and increase market share.

Originality/value
This study is more comprehensive than previous studies, combining halal and environmentally friendly elements with a focus on Generation Z.
Online complaint handling: a text analytics-based classification framework
Authors: Dobrucalı Yelkenci Birce , Özdağoğlu Güzin , İlter Burcu 
Published: April 2023

PurposeThis study aims to both identify content-based and interaction-based online consumer complaint types and predict complaint types according to the complaint magnitude rooted in complainants' personality traits, emotion, Twitter usage activity, as well as complaint's sentiment polarity, and interaction rate.Design/methodology/approachIn total, 297,000 complaint tweets were collected from Twitter, featuring over 220,000 consumer profiles and over 24 million user tweets. The obtained data were analyzed via two-step machine learning approach.FindingsThis study proposes a set of content and profile features that can be employed for determining complaint types and reveals the relationship between content features, profile features and online complaint type.Originality/valueThis study proposes a novel model for identifying types of online complaints, offering a set of content and profile features that can be used for predicting complaint type, and therefore introduces a flexible approach for enhancing online complaint management.
Suppressive effects of linzagolix, a novel non‐peptide antagonist of gonadotropin‐releasing hormone receptors, in experimental endometriosis model rats
Authors: Tezuka Motohiro , Tsuchioka Kumi , Kobayashi Kaoru , Kuramochi Yu , Kiguchi Sumiyoshi 
Published: April 2023

AbstractEndometriosis is an oestrogen‐dependent disease in which endometrial‐like tissue grows outside the uterus in women of reproductive age. Accordingly, control of oestradiol (E2) levels is an effective treatment for endometriosis. Because gonadotropin‐releasing hormone (GnRH) is the main controller of E2 secretion, control of GnRH signalling by GnRH antagonism is an effective strategy for the treatment of sex hormone‐dependent diseases such as endometriosis. The purpose of the present study was to evaluate the effects of the potent, orally available and selective GnRH antagonist linzagolix on experimental endometriosis in rats and compare them with those of dienogest, which is used clinically to treat endometriosis. Experimental endometriosis was induced in female rats at the proestrus stage of the oestrous cycle via autotransplantation of endometrial tissue into the renal subcapsular space. Linzagolix significantly decreased cyst volumes compared with the control group at doses of 50 mg/kg or more. Indeed, a suppressive effect of dienogest on cyst volume was observed only at the highest dose evaluated (1 mg/kg). The effective concentration of linzagolix, calculated as the free form of the last‐observed drug concentration, was ~1 μmol/L in endometriosis model rats. The present study also reveals that linzagolix exerts a sustained inhibitory effect on E2 secretion, indicating that the suppressive effect on endometriosis cyst volumes could be attributed to its pharmacological suppression of GnRH signalling and serum E2 concentrations. Altogether, our findings indicate that linzagolix may be a useful therapeutic intervention for hormone‐dependent diseases including endometriosis.