bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Literature Review: Adversity Quotient pada Kemampuan Pemecahan Masalah Matematis Siswa Berdasarkan Tahapan Polya
Authors: Sutisna Eki , Pujiastuti Heni 
Published: August 2023

Abstrak. Penelitian ini bertujuan untuk memperoleh deskripsi tentang cara siswa menyelesaikan masalah ditinjau dari kemampuan tinggi, sedang, rendah pada Adversity Quotient (AQ) berdasarkan tahapan penyelesaian masalah menurut Polya, yaitu: memahami masalah (understanding the problem); menyusun rencana penyelesaian (devising a plan); menyelesaikan masalah sesuai rencana (carrying out the plan); memeriksa kembali hasil yang telah diperoleh (looking back). Penelitian ini menggunakan metode Systematic Literature Review (SLR). Langkah-langkah dalam penelitian ini meliputi: develop research questions; selection criteria; developing the search strategy; the study selection process; coding studies; appraising the quality studies; dan synthesis result. Dari hasil pencarian, diperoleh 15 artikel yang memenuhi kriteria. Hasil dari penelitian ini menunjukkan bahwa siswa berkemampuan rendah atau quitter jika ditinjau dari AQ memiliki kesamaan dalam menyelesaikan masalah, mereka belum mampu mengikuti langkah-langkah penyelesaian masalah menurut Polya. Mereka masih kesulitan dalam memahami masalah yang dihadapi. Untuk siswa berkemampuan sedang, atau jika ditinjau berdasarkan AQ yaitu camper, sudah mampu mengikuti sebagian langkah-langkah penyelesaian masalah menurut Polya walaupun belum sempurna. Hal tersebut berkaitan dengan karakteristik camper yang cepat merasa puas dengan hasil yang diperoleh. Berbeda dengan siswa berkemampuan tinggi, atau bisa disebut juga dengan climber, mereka sudah mampu mengikuti langkah-langkah penyelesaian masalah menurut Polya. Hal yang menjadi perhatian adalah ketelitian.Kata Kunci: Pemecahan Masalah, Matematika, Polya, Adversity Quotient (AQ).
Hybrid Learning dalam Perkuliahan Matematika Kimia 1
Authors: Kusuma Dianne Amor , Noto Muchamad Subali , Dwipriyoko Estiyan 
Published: August 2023

Abstrak. Latar belakang dari penelitian ini adalah hasil belajar mahasiswa program studi kimia FMIPA, Universitas Padjadjaran, dalam mata kuliah Matematika Kimia 1 masih rendah, dan pandemi Covid-19 yang mengakibatkan proses pembelajaran belum memungkinkan untuk dilaksanakan secara tatap muka langsung sehingga berdampak terhadap pemahaman dan motivasi mahasiswa. Penelitian ini perlu dilakukan karena hybrid learning adalah metode pembelajaran yang saat ini dijadikan sebagai alternatif metode pembelajaran yang diterapkan selama masa pandemi. Penelitian ini membahas tentang sejauhmana hybrid learning telah diterapkan dalam perkuliahan Matematika Kimia 1. Metode penelitian yang digunakan adalah penelitian deskriptif. Hasil dari penelitian ini memperlihatkan bahwa hybrid learning memiliki kekuatan dan kelemahan, serta dapat membantu mahasiswa lebih memahami dan termotivasi dalam mata kuliah mata kuliah Matematika Kimia 1 dengan bantuan beberapa aplikasi yang bersifat interaktif. Kesimpulan dari penelitian ini adalah bahwa hybrid learning yang didukung oleh beberapa aplikasi yang bersifat interaktif, berpeluang meningkatkan pemahaman dan motivasi mahasiswa dalam perkuliahan Matematika Kimia 1. Kata Kunci: Hybrid learning, Matematika Kimia, Hasil Belajar, Motivasi.
Kategori Mahasiswa Calon Guru Matematika Dalam Memecahkan Masalah Duplikasi Kubus Zaman Thales-Euclid
Authors: Harisman Yulyanti , Arfah Aisya , Harun Lukman , Habibah Marsha 
Published: August 2023

Abstrak. Duplikasi kubus adalah menggambarkan/membangun rusuk sebuah kubus sehingga volumenya menjadi dua kali volume kubus yang diketahui. Yang mana duplikasi kubus ini merupakan salah satu dari tiga masalah matematika yang sangat menarik yang tidak bisa terpecahkan tiga abad terakhir sebelum masehi. Maka dari itu, penulis tertarik untuk menulis artikel ini dengan tujuan mengingatkan kembali kepada mahasiswa calon guru mengenai pemecahan masalah tentang duplikasi kubus zaman Thales-Euclid. Penelitianyang dipakaimerupakan kualitatif menggunakan metode studi kasus. Dari 5 kelas diambil masing- masing 2 orang pada program studi pendidikan matematika menjadi subjek penelitian. Instrumen yang dipakai dalam penelitian ini adalah wawancara terbuka. Setiap mahasiswa diberikan pertanyaan tentang pemecahan masalah duplikasi kubus. Analisis data bersifat tematik. Hasil penelitian menunjukkan sejauh mana pengetahuan mahasiswa calon guru merespons apa yang diketahui tentang duplikasi kubus dan pemecahan masalahnya. Kategori jawaban mahasiswa akan dipaparkan secara rinci pada tulisan ini.Kata Kunci: Duplikasi, Kubus, Mahasiswa Calon Guru Matematika.
İlk trimester tarama testindeki biyokimyasal parametrelerin maternal ve fetal morbiditeyi öngörmedeki değerinin araştırılması–Retrospektif Vaka-Kontrol Çalışması
Authors: KAPLAN İsa 
Published: August 2023

AMAÇ: Bu araştırma maternal serum gebelikle ilişkili plazma protein A, serbest beta human koryonik gonadotropin düzeylerinin obstetrik komplikasyonlar ile ilişkisini incelemek amacıyla yapılmıştır.
MATERYAL-METOD: Bu araştırma retrospektif vaka-kontrol çalışmasıdır. Araştırma Aydın Adnan Menderes Üniversitesi Hastanesi’nde Ocak 2015 ve Kasım 2016 tarihleri arasında yapılmıştır. Down sendromu taraması için 1. Trimester tarama belirteçleri ve ense kalınlığına bakılmıştır. Çalışma doğum sonrası down sendromu olmayan tekil 250 gebe ile yapılmıştır. Çoğul gebeliği olan ve fetal kromozomal anomalileri olan kadınlar çalışma dışı bırakılmıştır. Verilerin değerlendirilmesinde Ki-Kare testi, Fisher’s Exact test ve Continuity Correction (Yates) test kullanılmıştır.
BULGULAR: Gebelerin yaş ortalaması 29,52±6,17, gebelik haftası ortalaması 12,2±0,8’dir. Olguların pregnancy associated plasma protein A (PAPP-A) düzeyleri ortalaması 0,92±0,40 multiples of the median (MoM), Beta human chorionic gonadotrophin (ß-hCG) düzeyleri ortalaması 1,36±0,98 MoM nukal translüsensi (NT) MoM değerleri ortalaması 0,92±0,31 MoM’dir. Olguların %28,8’inde erken doğum tehdidi (EDT), %20’sinde gebelik yaşına göre küçük bebek (SGA), %18,8’inde gestasyonel diabetes mellitus (GDM), %15,6’sında fetal distress, %15,6’sında erken doğum eylemi, %14,4’sında intrauterin gelişme geriliği (IUGR), %12,8’inde oligohidramnios ve %12’sinde erken membran rüptürü (EMR) komplikasyonu geliştiği saptanmıştır. Maternal serum PAPP-A≤0,5 MoM değeri ile GDM, EDT, erken doğum, EMR, oligohidramnios, polihidramnios, IUGR, SGA ve preterm doğum gelişimi arasında istatiksel olarak anlamlı bir ilişki tespit edilmiştir. Çalışmamızda serbest ß-hCG için düzeltilmiş sınır değer ≥2,5 MoM olarak alınmış olup irdelediğimiz gebelik sonuçları ile anlamlı birliktelik saptanmamıştır.
SONUÇ: Birinci trimester tarama testi sonuçları kromozomal anomaliler ile birlikte birçok istenmeyen gebelik sonucu için erken dönemde uyarıcı ölçüt olarak kullanılarak hastaların erken tanı ve uygun yönetimi planlamak için yararlanılabilir.
Emotional Education in Elementary Schools: A systematic review from 2015 to 2017
Authors: Ramírez Delgado Nieves , Bermúdez-Torres Carlos , Conde Cristina , Jiménez-Vicioso Juan Ramón 
Published: August 2023

This article presents a literature review of emotional education in elementary schools. The topic in question is considered of utmost importance. To this end, articles published on the Web of Science (WOS) during the years 2015, 2016 and 2017. The 37 selected articles, after cleaning up the data, were classified by subject for analysis according to whether they addressed the students or the teachers. 31 of the earmarked documents investigated students and 8 teachers. For the student documents, the articles were classified according to the role that emotional education played: as an end in itself, 18 articles, as a means, 12, and together with other variables, 4 documents. The articles intended for teachers focus on the initial training, as well as on the ongoing training, getting the results of the experience of these and of the development of emotional education in the classroom.
Molecular identification of phlebotomine sand flies and the harbored Leishmania spp. in Sokoto State, Nigeria
Authors: Usman Mahmud , Natala Audu Joseph , Jatau Isa Danladi , Ogo Ndudim Isaac , Jeelani Ghulam , Goto Yasuyuki , Nozaki Tomoyoshi , McKerrow James H. , Balogun Emmanuel Oluwadare 
Published: August 2023

IntroductionFemale sand flies are hematophagous, feeding on animals and in the process serve as vectors for Leishmania, the parasites that cause leishmaniasis in humans. Leishmaniasis are a group of parasitic neglected tropical diseases in 98 countries including Nigeria and kills ~60,000 people/year. In Nigeria, Sokoto State is endemic to leishmaniasis but there is a knowledge gap on the identity of the prevalent sand flies and the Leishmania species they transmit. Hence, this cross-sectional study was designed to take inventory of the species of sand flies in Sokoto using genetic methods.Methods1,260 (310 females) sand flies were collected from three Local Government Areas (L.G.A) of Sokoto State- Wamakko, Sokoto South and Kware. Genomic DNA was extracted from each fly and DNA amplification by polymerase chain reaction (PCR) was carried out on the DNA samples using primers targeting the arthropods mitochondrial cytochrome oxidase subunit 1 (mt-coI) gene, and nested PCR with primers targeting the gene for Leishmania internal transcribed spacer-1 (its-1) of ribosomal RNA its-1rRNA. The PCR products were sequenced.ResultsGene sequence analysis revealed five species of sand flies belonging to the old-world genera namely Phlebotomus and Sergentomyia. The identified species were P. papatasi (6.45%), S. adleri (6.45%), S. affinis (9.7%), S. distincta (9.7%), S. schwetzi (67.7%). Within the sampling period, sand flies were most abundant in the rainy months of August (104/33.5%) and September (116/37.4%) with all the five identified species occurring. Sequence analysis of its-1 gene identified Leishmania infantum in two sand flies (2/310)- P. papatasi (from Sokoto South) and S. affinis (from Wamakko). BLAST search in NCBI and phylogenetic analysis revealed that the sand fly species are related to the species reported in different parts of Africa, while the L. infantum is identical to strain reported in Brazil (KY379083.1).DiscussionPhlebotomus papatasi and four species belonging to the genus Sergentomyia are the most prevalent sand flies in Sokoto State, Nigeria and they harbor L. infantum solely. The results shed light on why visceral leishmaniasis is the most predominant form of the disease. Therefore, we recommend that adequate care for dogs must be instituted as dogs are the major animal reservoir for L. infantum.
Controlled attenuation parameters to assess liver steatosis in obese patients with polycystic ovary syndrome
Authors: Wang Dongxu , Nan Nan , Bing Hao , He Bing 
Published: August 2023

ObjectivesThis study was performed to investigate the changes and influencing factors of liver controlled attenuation parameter (CAP) in obese patients with polycystic ovary syndrome (PCOS), and to determine the prevalence and risk factors of nonalcoholic fatty liver disease (NAFLD) in PCOS patients with obesity.MethodsForty-one PCOS patients with obesity and twenty age- and body mass index (BMI)-matched control women without PCOS were enrolled in this study. General data, body composition, biochemical parameters, sex hormones, and liver CAP in the two groups were collected and compared. Liver CAP was measured using transient elastography.ResultsNAFLD was more common in the Obese PCOS group than in the control group (75.61% vs. 45.00%, P=0.018). Compared to the control group, the obese PCOS group showed apparent increases in alanine transaminase (ALT), aspartate transaminase (AST), CAP, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), totle testosterone (TT), free androgen index (FAI), fasting insulin (FIns), and homeostasis model assessment-insulin resistance (HOMA-IR), along with lower high-density lipoprotein cholesterol (HDL-C) and sex hormone binding globulin (SHBG) levels. In addition, as shown by Spearman analysis, liver CAP in PCOS patients with obesity had a positive correlation with ALT, AST, TG, TT, FAI, FIns, and HOMA-IR, and a negative correlation with SHBG. Logistic regression analysis showed that TG, TT, FIns, and HOMA-IR were risk factors for NAFLD, while TT was an independent risk factor for NAFLD in PCOS patients with obesity.ConclusionPCOS patients with obesity had a significantly higher prevalence of NAFLD. Furthermore, in PCOS patients with obesity, liver CAP was associated with disorders of lipid metabolism, insulin resistance, and hyperandrogenemia, with elevated testosterone levels being an independent risk factor for NAFLD in PCOS patients with obesity.
Gold nanoparticles attenuate the interferon-γ induced SOCS1 expression and activation of NF-κB p65/50 activity via modulation of microRNA-155-5p in triple-negative breast cancer cells
Authors: Farhana Aisha , Alsrhani Abdullah , Rasheed Naila , Rasheed Zafar 
Published: August 2023

ObjectiveTriple-negative breast cancer (TNBC) is a very aggressive form of cancer that grows and spreads very fast and generally relapses. Therapeutic options of TNBC are limited and still need to be explored completely. Gold nanoparticles conjugated with citrate (citrate-AuNPs) are reported to have anticancer potential; however, their role in regulating microRNAs (miRNAs) in TNBC has never been investigated. This study investigated the potential of citrate-AuNPs against tumorigenic inflammation via modulation of miRNAs in TNBC cells.MethodsGold nanoparticles were chemically synthesized using the trisodium-citrate method and were characterized by UV-Vis spectrophotometry and dynamic light scattering studies. Targetscan bioinformatics was used to analyze miRNA target genes. Levels of miRNA and mRNA were quantified using TaqMan assays. The pairing of miRNA in 3'untranslated region (3'UTR) of mRNA was validated by luciferase reporter clone, containing the entire 3'UTR of mRNA, and findings were further re-validated via transfection with miRNA inhibitors.ResultsNewly synthesized citrate-AuNPs were highly stable, with a mean size was 28.3 nm. The data determined that hsa-miR155-5p is a direct regulator of SOCS1 (suppressor-of-cytokine-signaling) expression and citrate-AuNPs inhibits SOCS1 mRNA/protein expression via modulating hsa-miR155-5p expression. Transfection of TNBC MDA-MB-231 cells with anti-miR155-5p markedly increased SOCS1 expression (p&lt;0.001), while citrate-AuNPs treatment significantly inhibited anti-miR155-5p transfection-induced SOCS1 expression (p&lt;0.05). These findings were validated by IFN-γ-stimulated MDA-MB-231 cells. Moreover, the data also determined that citrate-AuNPs also inhibit IFN-γ-induced NF-κB p65/p50 activation in MDA-MB-231 cells transfected with anti-hsa-miR155-5p.ConclusionNewly generated citrate-AuNPs were stable and non-toxic to TNBC cells. Citrate-AuNPs inhibit IFN-γ-induced SOCS1 mRNA/protein expression and deactivate NF-κB p65/50 activity via negative regulation of hsa-miR155-5p. These novel pharmacological actions of citrate-AuNPs on IFN-γ-stimulated TNBC cells provide insights that AuNPs inhibit IFN-γ induced inflammation in TNBC cells by modulating the expression of microRNAs.
The efficacy and practicality of the Neurotrack Cognitive Battery assessment for utilization in clinical settings for the identification of cognitive decline in an older Japanese population
Authors: Glenn Jordan M. , Bryk Kelsey , Myers Jennifer R. , Anderson John , Onguchi Kaori , McFarlane Jacob , Ozaki Satoshi 
Published: August 2023

IntroductionJapan has the largest aging population with 33% of the population over the age of 60 years. The number of Japanese adults with dementia is estimated to be approximately 4.6 million, comprising nearly 15% of the older adult population. It is critical to administer cognitive assessments early in the disease state that have high reliability and low user burden to detect negative cognitive changes as early as possible; however, current preclinical AD detection methods are invasive, time-consuming, and expensive. A number of traditional and digital cognitive assessments are also available, but many of these tests are time-consuming, taxing to the user, and not widely scalable. The purpose of this study was to incorporate a digital cognitive assessment battery into a standard clinical assessment performed within a Japanese-based neuropsychology clinic to assess the diagnostic accuracy and the relationship between the digital Neurotrack Cognitive Assessment Battery (N-CAB) to traditional cognitive assessments.MethodsHealthy individuals and probable Alzheimer's patients completed the N-CAB, as well as two traditional cognitive assessments, the Mini Mental Status Exam (MMSE) and the Revised Hasegawa's Dementia Scale (HDS-R).ResultsOur results demonstrate the Image Pairs hand-response phase of the N-CAB had the highest diagnostic accuracy with 95% sensitivity and 89% specificity to probable Alzheimer's disease. This was closely followed by the Symbol Match assessment, with a 96% sensitivity and 74% specificity to probable Alzheimer's disease. Additionally, Symbol Match and Path Points used in combination resulted in a sensitivity of 94%, specificity of 90%; a model with all N-CAB assessments resulted in a sensitivity and specificity of 100%. All N-CAB assessments had moderate to strong and significant correlations with the MMSE and HDS-R.DiscussionTogether, this suggests that the N-CAB assessment battery may be an appropriate alternative for the clinical screening of cognition for earlier detection of Alzheimer's disease.
Molecular profiling and specific targeting of gemcitabine-resistant subclones in heterogeneous pancreatic cancer cell populations
Authors: Färber Benedikt , Lapshyna Olga , Künstner Axel , Kohl Michael , Sauer Thorben , Bichmann Kira , Heckelmann Benjamin , Watzelt Jessica , Honselmann Kim , Bolm Louisa , ten Winkel Meike , Busch Hauke , Ungefroren Hendrik , Keck Tobias , Gemoll Timo , Wellner Ulrich F. , Braun Rüdiger 
Published: August 2023

PurposeChemotherapy is pivotal in the multimodal treatment of pancreatic ductal adenocarcinoma (PDAC). Technical advances unveiled a high degree of inter- and intratumoral heterogeneity. We hypothesized that intratumoral heterogeneity (ITH) impacts response to gemcitabine treatment and demands specific targeting of resistant subclones.MethodsUsing single cell-derived cell lines (SCDCLs) from the classical cell line BxPC3 and the basal-like cell line Panc-1, we addressed the effect of ITH on response to gemcitabine treatment.ResultsIndividual SCDCLs of both parental tumor cell populations showed considerable heterogeneity in response to gemcitabine. Unsupervised PCA including the 1,000 most variably expressed genes showed a clustering of the SCDCLs according to their respective sensitivity to gemcitabine treatment for BxPC3, while this was less clear for Panc-1. In BxPC3 SCDCLs, enriched signaling pathways EMT, TNF signaling via NfKB, and IL2STAT5 signaling correlated with more resistant behavior to gemcitabine. In Panc-1 SCDCLs MYC targets V1 and V2 as well as E2F targets were associated with stronger resistance. We used recursive feature elimination for Feature Selection in order to compute sets of proteins that showed strong association with the response to gemcitabine. The optimal protein set calculated for Panc-1 comprised fewer proteins in comparison to the protein set determined for BxPC3. Based on molecular profiles, we could show that the gemcitabine-resistant SCDCLs of both BxPC3 and Panc-1 are more sensitive to the BET inhibitor JQ1 compared to the respective gemcitabine-sensitive SCDCLs.ConclusionOur model system of SCDCLs identified gemcitabine-resistant subclones and provides evidence for the critical role of ITH for treatment response in PDAC. We exploited molecular differences as the basis for differential response and used these for more targeted therapy of resistant subclones.
Reductions in anxiety and depression symptoms in a subset of outpatients with problematic substance use who received ketamine-assisted psychotherapy: a two-year retrospective chart review
Authors: Whinkin Emily , Eparwa Therry Rose J. , Julseth Michelle C. , Schneider Andrea , Aggarwal Sunil K. 
Published: August 2023

ObjectiveAssess changes in symptoms of anxiety, depression, and psychosocial or spiritual distress before and after ketamine-assisted psychotherapy (KAP) in individuals with problematic substance use (PSU).MethodsA retrospective chart review was performed on participant data from two five-year prospective outcomes studies: the AIMS Medical Outcomes Study (AMOS) and the AIMS Cancer Outcomes Study (ACOS). The efficacy of KAP for anxiety, depression, and psychosocial or spiritual well being was assessed in patients with current, past, or high risk of substance use disorder. Validated psychometrics utilized were Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and the National Institute of Health - Healing Experiences of All Life Stressors (NIH-HEALS) questionnaires.ResultsBetween November 1, 2020 and October 31, 2022, a total of 18 patients identified with problematic substance use completed at least one KAP session and at least one baseline and post-KAP metric questionnaire. The PSU subpopulation average score changes were as follows: GAD-7 (-6.71 ± 9.15, n = 14); PHQ-9 (-7.44 ± 5.42, n = 16); and NIH-HEALS (5.13 ± 13.64, n = 15). The average score changes for the KAP population of enrolled subjects were as follows: GAD-7 (-2.45 ± 6.01, n = 104); PHQ-9 (-3.02 ± 6.01, n = 111); and NIH-HEALS (2.93 ± 11.91, n = 86). A comparison of average score changes (p &lt; 0.05) between the PSU subpopulation and KAP population were as follows: GAD-7 (0.0219, 95% C.I. 1.37-8.11); PHQ-9 (0.0062, 95% C.I. 1.28-7.56); and NIH-HEALS (0.5197, 95% C.I. 8.96-4.56). For patients with PSU, results demonstrate statistically significant improvements in anxiety and depression symptoms after at least one KAP session. Average NIH-HEALS scores increased, though not by a statistically significant amount. Compared to the general population of enrolled KAP patients during this period, patients with PSU reported significantly greater average reductions in GAD-7 and PHQ-9 scores.ConclusionUndergoing one to six ketamine-assisted psychotherapy (KAP) sessions was associated with improved anxiety and depression ratings in patients with problematic substance use. Two-thirds of participants also experienced improved psychosocial and spiritual well-being. The use of KAP may be important to consider as a therapy for reducing anxiety and depression symptoms in patients with problematic substance use.
Trois biographies du cura Brochero. Entre hagiographie et histoire, entre oligarchie et gauchos, un personnage significatif dans une Argentine qui se cherche
Authors: Pelbois Vincent 
Published: August 2023

« Tres biografias del cura Brochera. Entre hagiografia e historia, entre oligarquia y gauchos : un personaje tipico de una Argentina en busca de si misma ».
Segûn la formación que haya recibido quien emplea la palabra, «hagiografia» reviste principalmente dos significados distintos. La palabra nació en contexto claramente católico, puesto que el concepto de santidad, empleado por el pueblo judio antiguo como atributo de Dios, se ha difundido en el mundo católico, a raiz de los misterios de la encamación y de la redención, para aplicarse a todos aquellos que ontológica, psicológica y moralmente, se han dejado transformar por la gracia de Cristo hasta llegar a poder ser propuestos como modelos e intercesores para los fieles. Mientras que para quienes no usen la óptica católica, sino más bien una óptica «universitaria», la palabra se opone a la biografia en que significa más bien la propuesta de un modelo edificante, sin especial preocupación por la verdad histórica de lo que se dice del personaje estudiado. El présente articulo examina très biografias recientes, escritas en el momento en que su proceso de canonización entraba en competencia con el de Ceferino Namuncurá, de José Gabriel del Rosario Brochera, el «cura gaucho» de tras la sierra (de Córdoba, Argentina).