bluuebunny/crossref_metadata_2025_split huggingface dataset:
n-ras and k-ras Mutations Among Some Iraqi Patients with Acute Lymphoblastic Leukemia
Authors: Al-Amili Wiaam Ahmed , Al-Faisa Abdul Hussein Moyet l , Hussein Norrya Abdul , Tobal Khalid 
Published: August 2023

Somatic mutations which influence the activity of RAS genes, n-, h-, and k-ras, are recognized mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers. This persuades to search in coding genes suspected to be contributing to leukemogenesis such as n-ras and k-ras mutations that may associate with acute lymphoblastic leukemia for some Iraqi patients using a combination of high resolution melting-polymerase chain reaction (HRM-PCR) scanning with sequence analysis . This study was carried out on fifty Iraqi patients (34 male, 16 female), (2-70 years of age) with acute lymphoblastic leukemia (ALL) , including 20 pre-treated , 15 under-treated and 15 relapsed patients compared with a sample consisted of 50 apparently healthy individuals as control group collected randomly from population living in Baghdad (4 - 66 years of age). Of 50 ALL Iraqi patients , 6 patients were identified with an abnormal melting curve showing low frequency of ras genes mutations , this result is translated a poor prognostic for ras mutations in ALL . According to the results of this study the c.34 in exon 2 (codon 12) was a hot spot for n-ras mutations and c.35 in exon 2 (codon 12) was a hot spot for k-ras mutations in ALL Iraqi patients , while no codon 61 mutations were detected for either n-ras or k-ras gene .
ANALISIS IMPLEMENTASI UNDANG-UNDANG HARMONISASI PERATURAN PERPAJAKAN PADA UMKM DI KOTA BATAM
Authors: Khalid Ferdila , Mustika Ita , Khadijah Khadijah 
Published: August 2023

Undang-Undang Harmonisasi Peraturan Perpajakan merubah beberapa aturan perpajakan yang telah ada sebelumnya untuk mengurangi defisit Anggaran Pendapatan dan Belanja Negara tahun 2022 dan 2023. Pada Penelitian ini, peneliti menganalisis dari segi Pajak dan Pajak Pertambahan Nilai yang berubah dibeberapa aspek yang akan berdampak pada masyarakat dan pelaku usaha, yaitu perubahaan tarif PPN, bracket PPh orang pribadi serta dilakukannya tax amnesty. Tujuan penelitian ini adalah untuk mengkaji apakah Implementasi Undang-undang Harmonisasi Peraturan Perpajakan akan menjadi tantangan atau peluang bagi pelaku usaha dan masyarakat serta untuk mengetahui dampak implementasi Undang-Undang Harmonisasi Peraturan Perpajakan pada Pajak Penghasilan dan Pajak Pertambahan Nilai yang berpengaruh pada masyarakat dan pelaku usaha. Metode pengumpulan data yang digunakan data primer yaitu data yang diperoleh langsung dari responden yaitu dengan wawancara dan observasi tentang implementasi Undang-Undang Harmonisasi Peraturan Perpajakan serta data sekunder yaitu data dari internal perusahaan serta website dan buku perpustakaan tentang peraturan perpajakan. Pembaharuan regulasi sistem perpajakan melalui UU HPP dapat meningkatkan kemudahan berusaha, menambah lapangan pekerjaan, mempercepat pertumbuhan ekonomi, dan juga memberikan jaminan kepastian hukum serta mengefisiensikan kewajiban wajib pajak.
.Kata kunci: Harmonisasi Peraturan Perpajakan
Kapitalisme Digital dalam Media Sosial Youtube: Kritik Terhadap Perkembangan Teknologi Digital Berdasarkan Pemikiran Herbert Marcuse
Authors: Ishaq Anton , Saksono Eko Hari 
Published: August 2023

The development of digital technology which is so rapid at this time has an impact on changes in various lines of society. One of the changes in behavior and new habits can be seen in how people interact with various digital technology platforms that are used as channels of communication and socialization. Through these various digital platforms, the public can not only easily obtain information, but can also process and produce information. The change in role from consumer to producer is one of the influences of technology that drives society today to be in the information society era. However, user-generated content basically generates huge profits for social media operators through user-produced content and of course, also comes from advertisements. This monetization is perceived by users as an opportunity to earn income through social media. Thus, users are competing in various ways to produce content in order to achieve monetization in accordance with the terms and conditions of social media operators. On the one hand, it seems that these social media users are not aware that their existence in social media is basically an instrument of the system contained in social media itself. The data in this article was carried out by analyzing a number of YouTube application YouTuber accounts and conducting an analysis. A case study approach to see how the phenomenon of digital capitalization through YouTube is carried out by social media operators. Furthermore, the results of the analysis are examined with the one-dimensional human perspective of Herbert Marcuse
Pengakuan Sosial dan Nilai Pluralitas dalam Komunikasi Seni Lintas Busana Kontemporer
Authors: Razali Geofakta 
Published: August 2023

This research is a conceptual study that produces an understanding of pluralism that can be obtained through the communication actors of cross-dressing artists. This representation has an effect on the acceptance and acknowledgment of the plurality point of view in creating an attitude of respect for differences. Using the concept of recognition from Axel Honneth which provides an overview of social relations built on intersubjective grammar that influences human insight about differences. The researcher uses a qualitative method with a critical methodology to the form of practical dialectics and the theory of cross-dressing art performers, starting from their appreciation of themselves, and their communication behavior and social actions for a moral acceptance that is not in the realm of relativism or absolutism, but on recognition. So that intolerance can be reduced through an attitude of respect for the existence of others.
“In These Times of Compassion when Conformity’s in Fashion”: How Therapeutic Jurisprudence Can Root Out Bias, Limit Polarization, and Support Vulnerable Persons in the Legal Process
Authors: Perlin Michael L. 
Published: August 2023

This Article considers the extent to which caselaw has—either explicitly or implicitly—incorporated the precepts of therapeutic jurisprudence (“TJ”), a school of legal thought that focuses on the law’s influence on emotional life and psychological well-being, and that asks us to assess the actual impact of the law on people’s lives. Two of the core tenets of TJ in practice are commitments to dignity and to compassion. I conclude ultimately that with these principles as touchstones, TJ can be an effective tool—perhaps the most effective tool—in rooting out bias, limiting polarization, and supporting vulnerable persons in the legal process. But this cannot and will not happen until more judges and practicing attorneys understand the potentially reformative (and transformative) role of TJ. My review of some relevant caselaw (both domestic and international)—a review that, to the best of my knowledge, has never previously been undertaken—suggests that an incorporation of TJ principles is by no means a sure thing.
First, I briefly consider the creation and dynamic growth of therapeutic jurisprudence over the past 30 years, looking specifically at the interplay between TJ and values of dignity and compassion. Then, I assess the role of TJ in dealing with issues most central to this Article: bias, polarization, and vulnerability. I next review court decisions—both domestic and from other nations—in which TJ is explicitly mentioned (and in some cases, relied upon). Following this, I look at some other relevant caselaw in which (1) TJ implicitly helped bring about a solution that minimized bias or polarization, or offered support to vulnerable persons or classes; (2) the failure to employ TJ led to decisions that reinforced bias and ignored the needs of those who are vulnerable; or (3) a determination of one’s perspective is needed to determine if one sees the case as “pro-TJ” or “anti-TJ.” I then, in conclusion, offer some modest suggestions as to how TJ can best be employed to ensure decisions that are, optimally, bias free via approaches that improve therapeutic functioning and do not sacrifice civil liberties.
Direct and indirect linguistic measures of common ground in dialogue studies involving a matching task: A systematic review
Authors: Bovet Vincent , Knutsen Dominique , Fossard Marion 
Published: August 2023

AbstractDuring dialogue, speakers attempt to adapt messages to their addressee appropriately by taking into consideration their common ground (i.e., all the information mutually known by the conversational partners) to ensure successful communication. Knowing and remembering what information is part of the common ground shared with a given partner and using it during dialogue are crucial skills for social interaction. It is therefore important to better understand how we can measure the use of common ground and to identify the potential associated psychological processes. In this context, a systematic review of the literature was performed to list the linguistic measures of common ground found in dialogue studies involving a matching task and to explore any evidence of cognitive and social mechanisms underlying common ground use in this specific experimental setting, particularly in normal aging and in neuropsychological studies. Out of the 23 articles included in this review, we found seven different linguistic measures of common ground that were classified as either a direct measure of common ground (i.e., measures directly performed on the referential content) or an indirect measure of common ground (i.e., measures assessing the general form of the discourse). This review supports the idea that both types of measures should systematically be used while assessing common ground because they may reflect different concepts underpinned by distinct psychological processes. Given the lack of evidence for the implication of other cognitive and social functions in common ground use in studies involving matching tasks, future research is warranted, particularly in the clinical field.
Modelación Matemática Situada para Estudiantes de Administración Pública
Authors: Márquez Mónica Soto , Díaz Leonora 
Published: August 2023

Este estudio se inscribe en el ámbito de la relación educación y trabajo, con particular interés en explorar soluciones de continuidad entre las matemáticas de la formación con las matemáticas de la profesión. Con diseños de modelación matemática situada, de carácter socioepistemológico, se promueven en el aula la emergencia de las matemáticas de prácticas recurrentes de profesionales de la Administración Pública. En una perspectiva de investigación cualitativa y en su primera etapa, se indaga en el saber/hacer matemático expresado en prácticas de estos profesionales. En la segunda etapa se aplican diseños de modelación con base en las prácticas deconstruidas. Entre los resultados se reportan prácticas estudiantiles asociadas a la priorización para la toma de decisiones, a la vez que se observa la emergencia de configuraciones tempranas de identidad profesional. Estos resultados ilustran continuidades entre las matemáticas de la formación y las matemáticas de la profesión.
An Improved Second-Order Multi-Synchrosqueezing Transform for the Analysis of Non-Stationary Signals
Authors: Wang Kewen , Shang Yajun , Lu Yongzheng , Lin Tianran 
Published: August 2023

Second-order multi-synchrosqueezing transform (SMSST), an effective tool for the analysis of non-stationary signals, can significantly improve the time-frequency resolution of a non-stationary signal. Though, the noise energy in the signal can also be enhanced in the transform which can largely affect the characteristic frequency component identification for an accurate fault diagnostic. An improved algorithm termed as an improved second-order multi-synchrosqueezing transform (ISMSST) is then proposed in this study to alleviate the problem of noise interference in the analysis of non-stationary signals. In the study, the time-frequency (TF) distribution of a non-stationary signal is calculated first using SMSST, and then a δ function is constructed based on a newly proposed time-frequency operator (TFO) which is then substituted back into SMSST to produce a noise-free time frequency result. The effectiveness of the technique is validated by comparing the TF results obtained using the proposed algorithm and those using other TFA techniques in the analysis of a simulated signal and an experimental data. The result shows that the current technique can render the most accurate TFA result within the TFA techniques employed in this study.
Social Determinants of Hip Fractures in Elderly Patients–A Case-Control Study
Authors: KARAHAN Mümin , SAKÇI Mehmet Şah 
Published: August 2023

Aim: Hip fractures are common orthopedic traumas and are known as a problem in terms of public health, particularly among the elderly. Preventing fractures and determining risk factors are critical in reducing morbidity, mortality, and social and economic burden. The purpose of this study was to examine the social determinants affecting hip fractures.
Material and Methods: This case-control study was conducted with a case group of 108 (36.1%) patients and a control group of 191 (63.9%). Hip fracture status was selected as the dependent variable in the study. The independent variables were marital status, place of residence, single-story or multi-story residence, use of stairs, use of assistive devices, cohabitants, working status, chronic disease status, education status, fixed income status, health insurance, family history of hip fractures, fractures in the last five years, getting help in daily work, smoking, fear of falling, and perception of general health status.
Results: Marital status, cohabitants, chronic disease status, having a fixed income, having health insurance, fear of falling, and perception of general health differed to a significant extent between the case and control groups. Nonetheless, no statistically significant difference was found between the groups regarding their places of residence, living in whether single-story or multi-story residences, the use of stairs, assistive device usage, active employment status, education status, family history of hip fractures, fractures in the last five years, getting help in daily work, and smoking.
Conclusion: Social factors affect the risk of hip fracture. Clinicians should be alert to the importance of this issue and raise the awareness of elderly patients.
Exploring Options for Naming Taxa Based on DNA Sequences under the International Code of Nomenclature for Algae, Fungi, and Plants
Authors: Groom Quentin , Applequist Wendy , Lehtonen Samuli , Renner Susanne , Thiele Kevin 
Published: August 2023

DNA sequence data has gained increasing importance in modern taxonomic research, and related subjects such as species identification, biogeography, evolution, and classification. Environmental DNA reveals numerous taxa that cannot be isolated or cultured using current techniques. Yet, the latest International Code of Nomenclature for algae, fungi, and plants requires physical specimens or illustrations as nomenclatural types for the formal naming of species and subspecific taxa (Turland et al. 2018). This limitation is impeding our ability to describe, study and communicate about a significant proportion of biodiversity.
Here we present the deliberations of a Special-purpose Committee established at the XIX International Botanical Congress in Shenzhen, China, to address the issue of DNA sequences as types. Two main options for resolving this problem were identified:

Amend the definition of a 'type' in the Code to include DNA sequences.

Allow the description of taxa without types under specific circumstances.

Amend the definition of a 'type' in the Code to include DNA sequences.
Allow the description of taxa without types under specific circumstances.
Under either option, the Committee agreed to restrict the scope of the proposals to cases where the use of specimens or illustrations as types is not technically feasible (Thiele et al. 2023).
The inability to name taxa discovered through DNA sequencing has practical consequences that hinder research, conservation, and policy efforts. Whether this issue will be resolved depends on the voting at the Nomenclature Section of the XX International Botanical Congress to be held in Madrid in 2024. It is essential to engage with this process so that, whatever your opinion, your voice is heard at the Congress.
Symptom Appraisal and Help-Seeking Among Patients With Autoimmune Rheumatic Diseases: A Qualitative Study
Authors: Xiang Ling , Yoon Sungwon , Low Andrea H.L. , Leung Ying Ying , Fong Warren , Lau Tang Ching , Koh Dow Rhoon , Thumboo Julian 
Published: August 2023

ObjectiveLong diagnostic delay remains an unsolved problem in many autoimmune rheumatic diseases (ARDs). One of the major contributing factors is poor symptom appraisal and the resulting delays in help-seeking by patients themselves. We therefore aimed to understand the symptom appraisal and help-seeking experience among patients with ARDs in a multiethnic urban Asian population and to explore its influencing factors.MethodsSemistructured interviews with 33 patients with ARDs were audio recorded and transcribed verbatim. We coded the transcripts deductively using the reported 3 stages of symptom appraisal (detection, interpretation, and response) as the framework, and inductively for newly emerging themes and subthemes.ResultsAll 3 stages of the symptom appraisal and help-seeking journey (ie, symptom detection [by self and by others], symptom interpretation [causes, consequences, and required actions] and symptom response [no action, self-management, seeking help from nonhealthcare professionals, and seeking help from healthcare professionals]) were observed among patients. Interactions among these 3 stages were also observed: symptom interpretation was found to influence subsequent symptom detection, and the outcome of symptom response was found to influence both subsequent symptom detection and symptom interpretation. Various personal and socioenvironmental factors (eg, knowledge and cultural beliefs about the symptom) that influenced symptom appraisal and help-seeking were identified from the interviews.ConclusionThe symptom appraisal and help-seeking journey of patients with ARDs is an iterative process of detection, interpretation, and response, and is influenced by various personal and socioenvironmental factors. Addressing modifiable factors could shorten the symptom appraisal and help-seeking interval and improve patient outcomes.
Gênero orais da esfera científica na Base Nacional Comum Curricular
Authors: Storto Letícia Jovelina , Costa-Maciel Débora Amorim Gomes da , Magalhães Tania Guedes 
Published: August 2023

Neste artigo, analisamos a presença dos gêneros orais da esfera científica na Base Nacional Comum Curricular (BNCC) destinada ao Ensino Fundamental (1º ao 9º ano). Frente ao objeto em tela, refletimos sobre a concepção de oralidade que subjaz o documento; e buscamos identificar os gêneros orais de tal esfera indicados na BNCC para o campo científico. As inquietações direcionam nosso olhar para a análise documental e qualitativa no tratamento dos dados. Com vistas ao diálogo teórico, assumimos a oralidade como prática social manifestada numa diversidade de gêneros fundados na realidade sonora, bem como no tratamento didático do oral a partir de uma pedagogia específica. Os resultados sinalizam para dois cenários: i) apesar de a concepção de oralidade do documento reconhecer a supremacia da escrita, alguns desdobramentos não condizem com tal compreensão; ii) há presença de gêneros orais na esfera selecionada ao longo da Educação Básica, mas com distribuição desigual entre os anos iniciais (1º ao 5º) e anos finais (6º ao 9º). O cenário exige um maior investimento por parte dos sujeitos que usam a BNCC como documento normativo, no sentido de incorporar novos gêneros, sobretudo nos anos iniciais, e favorecer a ampliação das capacidades de linguagem nos aprendizes.
Palavras-chave: Gêneros orais; Esfera Científica; Base Nacional Comum Curricular.
Adjuvant antihypertensive effect of a novel Ayurvedic herbal formulation in fructose-induced albino rat model
Authors: Pratibha  , Rath Sudipta Kumar , Sharma Gaurav 
Published: August 2023

Abstract

BACKGROUND:
Hypertension is the most common treatable risk factor for cardiovascular disease. Hypertension is a multifactorial clinical condition and thus can be managed in multiple pathways. Management of hypertension with modern antihypertensive medication is not ideally effective due to side effects and adverse effects associated with their long-term use. Thus, a novel Ayurvedic formulation NIA/DG/2015/01 test drug (TD) was designed to address multiple pathway management of hypertension. Further, albeit the simultaneous use of modern and Ayurveda antihypertensive is common, there is no systematic study to evaluate the combined effect and adverse effect of this simultaneous use. This study is aimed to evaluate the antihypertensive activity of a novel Ayurvedic formulation (TD) both as an adjuvant with modern antihypertensive drugs and as a stand-alone drug in fructose-induced hypertensive albino rats.

METHODS:
TD comprises of the combination of aqueous extract of root of Boerhavia diffusa L., whole plant of Convolvulus prostratus Forssk., rhizome of Nardostachys jatamansi (D. Don) DC., bark of Terminalia arjuna (Roxb. ex DC.) Wight & Arn., and root of Withania somnifera (L.) Dunal. TD was administered 90 mg/kg body weight, P.O. twice a day for 28 days to evaluate its effect in fructose-induced hypertensive rats using the Quinapril as a standard drug. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured on day 7th, 14th, 21st, and 28th day of drug administration by noninvasive BP system for rodents.

RESULTS:
TD significantly reduced SBP and DBP in comparison to the standard drug Quinapril. (P < 0.001, one-way analysis of variance followed by Turkey’s multiple comparison test and Dunnett’s multiple comparison test).

CONCLUSION:
Ayurvedic formulation possesses significant antihypertensive activity in fructose-induced hypertensive albino rat model.
Safety assessment of Libirite capsule (a polyherbal formulation) in experimental animals (Sprague Dawley rats and Swiss albino mice)
Authors: Narke Vasant E. , Nipanikar Sanjay U. , Khisti Ujwala V. , Upasani Sachin A. 
Published: August 2023

Abstract

BACKGROUND:
Libirite capsule (LC) is a polyherbal formulation, developed to treat erectile dysfunction and loss of libido. Present study aimed to perform the acute oral toxicity studies of LC in Swiss Albino mice and Sprague Dawley rats, and repeated dose subchronic 90-day toxicity study were performed to assess the safety of LC.

METHODS:
LC was orally administered at 2000 mg/kg to the animals as per Organization for Economic Cooperation and Development (OECD)-423 guidelines. In a repeated dose oral toxicity study, LC was administered through oral gavage in a dose of 250, 500, and 1000 mg/kg for 90 days and compared with control groups as per OECD-408 guidelines. Posttreatment changes in food consumption, body weight, and biochemical, hematological, and laboratory parameters were observed.

RESULTS:
LC did not produce any adverse or mortality events in animals during acute studies. In a 90-day toxicity study, rats exhibited no toxicity symptoms or death. No significant changes were found in hematological and biochemical parameters. No significant alteration was seen in organ and body weight. Microscopic findings were incidental and identical for control and treated animals at 1000 mg/kg. LC did not produce any histopathological changes in target organs. No change in the recovery group was observed when compared with the control group animals, which indicated a complete reversal.

CONCLUSIONS:
Median lethal dose50 of LC was observed to be more than 2000 mg/kg. No observed adverse effect level of LC was considered 1000 mg/kg.