bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bidentate Antimony Pnictogen Bonding Host System
Authors: Beckmann J. Louis , Krieft Jonas , Vishnevskiy Yury V. , Neumann Beate , Stammler Hans‐Georg , Mitzel Norbert W. 
Published: September 2023

AbstractA bidentate pnictogen bonding host‐system based on 1,8‐diethynylanthracene was synthesized by a selective tin‐antimony exchange reaction and investigated regarding its ability to act as a Lewis acidic host component for the complexation of Lewis basic or anionic guests. In this work, the novel C≡C−Sb(C2F5)2 unit was established to study the potential of antimony(III) sites as representatives for the scarcely explored pnictogen bonding donors. The capability of this partly fluorinated host system was investigated towards halide anions (Cl−, Br−, I−), dimethyl chalcogenides Me2Y (Y=O, S, Se, Te), and nitrogen heterocycles (pyridine, pyrimidine). Insights into the adduct formation behavior as well as the bonding situation of such E⋅⋅⋅Sb−CF moieties were obtained in solution by means of NMR spectroscopy, in the solid state by X‐ray diffraction, by elemental analyses, and by computational methods (DFT, QTAIM, IQA), respectively.
A sustainable alternative? A comparative life cycle assessment of epoxy adhesives
Authors: Anastasiou Dimitrios E. 
Published: September 2023

AbstractIn response to the imperative of eco‐friendly material substitution, a comparative cradle‐to‐gate life cycle assessment (LCA) of two epoxy adhesives is presented: a traditional epoxy resin and an innovative self‐curing epoxy derived by epoxidizing poly‐beta‐myrcene (a constituent of Chios Mastic natural resin). Employing ReCiPe 2016 indicators and standard normalization, our study reveals that epoxidized poly‐beta‐myrcene outperforms conventional epoxy in 9 of 18 assessed midpoint indicators, with minimal impact in 7, and marginally higher impact in 2. The superiority of epoxidized poly‐beta‐myrcene extends to all three ReCiPe Endpoint protection areas. Atom economy and the E‐factor are also considered and related to the LCA results. Furthermore, the evaluation demonstrates epoxidized poly‐beta‐myrcene's remarkable environmental favorability compared to a literature bio‐based epoxy across multiple CML‐IA‐baseline indicators. In summary, epoxidized poly‐beta‐myrcene emerges as a promising, ecologically sensitive alternative to current conventional and bio‐based epoxy options.
Integrating basic, clinical, and health system science in a medical neuroscience course of an integrated pre‐clerkship curriculum
Authors: Goodwin Richard L. , Black Asa C. , Nathaniel Thomas I. 
Published: September 2023

AbstractBasic science, clinical science, and health system science (HSS) have become three pillars of integration upon which modern, post‐Flexner, medical education is now based. Because of this new approach to curricular integration in a clinical presentation curruculum, medical training is now placed in the context of healthcare delivery. This study described the design, implementation, and assessment of an integrated teaching strategy, including the effect on students' performance in a medical neuroscience course's summative and formative examinations of an integrated clinical presentation curriculum. The integrated teaching of basic science content, clinical case discussion, and HSS was performed in the first year of an allopathic integrated pre‐clerkship curriculum. The two cohorts were from two different years, spring 2018 and 2019. The acceptance of the integrated teaching strategy by medical students was above 80% in all categories that were assessed, including enhancing the integrated experience in learning basic and clinical science materials in the context of HSS; understanding of the learning lessons; facilitation of self‐directed learning; provision of a better learning environment; and a holistic understanding of materials including the relevance of HSS issues in the discussion of neurological cases in the medical career of the students. More than 90% of the students scored ≥70% in summative questions mapped to the four learning objectives of the integrated teaching session. The objectives are the correlation of structure to specific functions (94.0 ± 0.21), clinical anatomical features of the nervous system (95.0 ± 0.27), cross‐sectional features of the nervous system (96.0 ± 0.31), and the effect of lesions on the structure and functional pathways of the nervous system (97.0 ± 0.34). This result was significantly higher when compared to students' performance in the non‐integrated teaching cohort (p < 0.05). Formative assessments (F(7,159) = 92.52, p < 0.001) were significantly different between the two groups. When medical students were evaluated using the same questions for formative assessment, they performed better in the integrated teaching cohort (*p < 0.05) compared to the non‐integrated teaching cohort (**p < 0.05).
Is gastroschisis associated with county‐level socio‐environmental quality during pregnancy?
Authors: Krajewski Alison K. , Patel Achal , Gray Christine L. , Messer Lynne C. , Keeler Corinna Y. , Langlois Peter H. , Reefhuis Jennita , Gilboa Suzanne M. , Werler Martha M. , Shaw Gary M. , Carmichael Suzan L. , Nembhard Wendy N. , Insaf Tabassum Z. , Feldkamp Marcia L. , Conway Kristin M. , Lobdell Danelle T. , Desrosiers Tania A. ,   The National Birth Defects Prevention Study
Published: September 2023

AbstractBackgroundGastroschisis prevalence more than doubled between 1995 and 2012. While there are individual‐level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood.MethodsWe used the U.S. Environmental Protection Agency's Environmental Quality Index (EQI) as a county‐level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls).ResultsOverall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain‐specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality.ConclusionsFuture work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.
Evaluation of a rapport‐building intervention for early interventionists working with children on the autism spectrum
Authors: Ensor Rebecca , Burnham Riosa Priscilla , Yu Kevin Han Xiang 
Published: September 2023

AbstractRapport, or the therapeutic relationship between a therapist and client, is essential for successful intervention. In behavior analytic interventions for autistic children, practitioners commonly use pairing to establish rapport. A limited body of research has evaluated how to train interventionists to pair with their child clients. Furthermore, fewer studies have examined the effects of pairing on client behavior. Therefore, we implemented behavioral skills training to teach interventionists pairing skills and assessed the effects of presession pairing on child interfering behavior using a concurrent multiple probe design (with replication). We implemented a pairing protocol before early intensive behavioral intervention sessions with four children (3–5 years old) on the autism spectrum. Interventionists mastered pairing skills during training sessions, which were generally maintained when working with child clients. When interventionists implemented presession pairing, child participants demonstrated fewer interfering behaviors. We discuss implications of our preliminary findings and future directions.
Accepting the ASIS&T 2015 Award of Merit
Authors: Koenig Michael E. D. 
Published: September 2023

EDITOR'S SUMMARYIn receiving the ASIS&T Award of Merit for 2015, Michael E. D. Koenig recognized his many collaborators, mentors and those who have stimulated his thinking on numerous topics in information science. Koenig reflected on his wide‐ranging past studies, weaving through bibliometrics, information systems, library automation and education for library and information science. Koenig adapted citation analysis to develop a metric for pharmaceutical R&D demonstrating that citation data is a valid measure of research impact, and he has written extensively on the connection between an organization's information services and its productivity. In Koenig's view, knowledge management is the effort to build an information environment within an organization that supports its research effectiveness; it is a key contributor to organizational impact. Koenig hopes to see knowledge management, rooted in a strong information environment, serve as a catalyst for impact.
President's Page
Authors: Caidi Nadia 
Published: September 2023

EDITOR'S SUMMARYNadia Caidi, 2016 ASIS&T president, reported on attending conferences of the Council of Scientific Society Presidents (CSSP), the American Library Association (ALA) and ALISE (Association for Library and Information Science Education), highlighting the groups' intersecting interests and overlapping challenges. Information issues were present across much of the CSSP conference, including a focus on human behavior and interaction, adapting to changes in scholarly publishing and maintaining data integrity and security. The Midwinter Meeting of ALA, of which ASIS&T is an affiliate, included developments in library and information services and demonstrated the strong ties between the organizations and our goals. At the ALISE meeting training and accreditation were focal points; ASIS&T will participate in ongoing discussions on the topic. Planning for the ASIS&T 2016 Annual Meeting in Copenhagen continues, certain to deliver a stimulating mix of views on the fields of library and information science and technology.
Using Technology to Transform Education: Aaron Doering Addresses Annual Meeting
Authors: Hardin Steve 
Published: September 2023

EDITOR'S SUMMARYAt the 2015 ASIS&T Annual Meeting Aaron Doering, professor of learning technologies at the University of Minnesota, shared his passion for using technology to transform education. Doering offered transformational advice for the teaching and learning process, starting with the importance of creating experiences that engage learners and inspire change. Doering's approach is based on adventure learning, enabling students to design their learning experiences, studying real world issues through his team's on‐site activities and coordinating with related classroom learning opportunities. Linked by global information services, collaborative learning occurs without boundaries. Students can share stories with community members around the world, continually broadening their awareness, perspective and connections and even be recognized as topic experts in their own geographic areas. Doering urged meeting attendees to actively pursue innovation in education and to maximize the potential of technology to transform and expand learning possibilities.
SIG/MET: METRICS 2015: Workshop on Informetric and Scientometric Research
Authors: Haustein Stefanie 
Published: September 2023

EDITOR'S SUMMARYAt the fifth SIG/MET workshop, held during the 2015 ASIS&T Annual Meeting, the group shared papers, posters and discussions exploring developments in information measurement. The opening session on bibliometric case studies examined interdisciplinarity among consumers of academic research, increased funding for coauthors of previously funded authors and a classification of acknowledgement types. A session on information retrieval in relation to bibliometrics included studies on overcoming the limits of computational linguistics in very large corpora, an interactive context explorer of bibliographic data called Ariadne and comparative approaches to visualizing the structure of a very large dataset. The alternative metrics session covered application of altmetrics for analyzing public policy documents, a novel usage indicator promoting article discovery, the basis for connections among faculty members using Twitter and the heavy use of Twitter among academics. The daylong workshop included awards for best papers, best student papers and two featured presentations on the application and use of metrics.
SIG/SI Workshop: 11th Annual SIG‐SI Research Symposium a Success!
Authors: Fichman Pnina , Rosenbaum Howard 
Published: September 2023

EDITOR'S SUMMARYAt the 2015 ASIS&T Annual Meeting, Special Interest Group/Social Informatics (SIG/SI) celebrated its 11th research symposium and the more than 100 panels, papers and posters presented over the years. The theme, “The Impacts of Social Informatics Research,” was evident in studies illustrating social informatics in a variety of contexts. Speakers explored the use of communications technology in marginalized communities and language use in informal chat about illegal behavior in online communities. Presenters also examined human rights in Indonesia, taking a value‐oriented approach in social informatics research, efforts to create a safer internet and ways big data marginalize individuals through algorithms used in quantitative analyses. A panel considered where social informatics fits in the IT curriculum of iSchools. An examination of social connectedness through digital channels and devices won the Best Paper Award.
SIG CON Research Symposium: [Insert Title Here: Make Sure to Satisfy Titular Colonicity]
Authors: Fleischmann Kenneth R. , Worrall Adam , Anderson Theresa Dirndorfer , Goggins Sean , Burnett Gary 
Published: September 2023

EDITOR'S SUMMARYBringing comic relief to the 2015 ASIS&T Annual Meeting, SIG CON opened with discovery that the alleged nephew of the group's figurehead, Dr. Llewellyn C. Puppybreath III, and speaker at the 2014 meeting was an imposter of dubious character. With the purloined ceremonial wand accounted for, the 2015 symposium opened with a presentation on the I‐Index, an anti‐establishment altmetric, eschewing group recognition in favor of individualism and self‐citation. A paper on the correlation among computer science doctorates, rising arcade revenues and climate warming in Australia highlighted the income and career opportunities available to techies relocating to Oz. Analysis of ASIS&T members' social media posts revealed a skewed distribution of posters, topics and irrelevant content, especially by Association leadership. The session also featured a Monty Python character reporting on fatal answers at the Bridge of Death, multiple personalities of Dr. N. E. Doofus and a séance with illustrious ASIS&T members spanning the spectrum from living to dead.
Vivianite for Phosphorus Recovery from Digester Supernatant in Wastewater Treatment Plants
Authors: Amjad Salman , Christensen Morten Lykkegaard , Reitzel Kasper , Qu Haiyan 
Published: September 2023

AbstractPhosphorus (P) recovery by crystallization of vivianite in digester supernatant (DS) was investigated. A high recovery yield (> 90 %) was obtained with vivianite even for DS with low P concentration (74 mg L−1), as opposed to the formation of struvite and hydroxyapatite where the yield was lower than 50–60 %. Various strategies were tested to produce vivianite with large sizes and narrow size distribution, such as a controlled reagent dosing profile, self‐seeded crystallization, and multistage cascade‐seeded crystallization. The obtained results demonstrated that the main challenge in the development of vivianite P recovery is to promote crystal growth and to suppress secondary nucleation of vivianite during the crystallization process.
Catalytic desorption of CO2‐loaded solutions of diethylethanolamine using bentonite catalyst
Authors: Sarode Urvashi K. , Vaidya Prakash D. 
Published: September 2023

AbstractThe absorption of CO2 gas into aqueous alkanolamine solutions is the most advanced CO2 separation technology and a key challenge in this technique is the energy‐intensive process of solvent regeneration. The tertiary amine N,N′‐diethylethanolamine (or DEEA) is a candidate CO2‐capturing solvent with potential. To improve the energy efficiency of regeneration of DEEA, several catalysts were used for desorbing CO2 from loaded solutions of DEEA (2.5 M) at T = 363 K. Desorption trials were conducted in batch mode. The initial CO2 loading varied in the 0.3–0.35 mol CO2/mol DEEA range. The performance was analyzed by calculating the rate of CO2 desorption, cyclic capacity, and reduction in sensible energy. The amount of thermal energy needed for amine regeneration was significantly lowered by using nine transition metal oxide catalysts and the hierarchy was as follows: Al2O3 < MoO3 < V2O5 < TiO2 < MnO2 < ZnO < Cr2O3 < SiO2 < ZrO2. Among the metal oxides, Al2O3 increased desorption efficiency compared to blank runs by 89%. A clay‐based powder bentonite was also used as catalyst and its efficacy was compared with the metal oxides. This cheap and easily available bentonite catalyst was tuned through simple ion‐exchange with four acids (HCl, H3PO4, HNO3, and H2SO4). Upon treatment with H2SO4, bentonite remarkably increased desorption efficiency by 100%. Furthermore, bentonite catalyst treated with sulphuric acid (denoted here as Bt/H2SO4) was characterized by Brunauer–Emmett–Teller (BET), scanning electron microscopy (SEM), Fourier transform infrared spectrometery (FTIR), X‐ray diffraction (XRD), and ammonia temperature‐programmed desorption (NH3‐TPD). In this way, a comprehensive study on catalytic desorption of DEEA was performed.
Cardiovascular risk and biopsychosocial interplay: Association among hypertension, anxiety, and emotional dysregulation—observational study in primary care setting for efficient self‐care
Authors: Di Giacomo Dina , Ranieri Jessica , Guerra Federica , Cilli Eleonora , Sciarra Luigi , Romano Silvio 
Published: September 2023

AbstractBackgroundAim of the study was to explore the relationship between emotional dimensions of hypertensive patients and the self‐care skills; we tried to draw the psychological aspects could impact the health management in hypertension analyzing the effect of emotional regulation on self‐care skills: our scope was to highlight the psychological dynamics into behavioral medicine approach.MethodsIn an observational study design, patients were collected. Patients with diagnosis of hypertension were recruited in primary care setting. Inclusion criteria included patients older than 18 years, with known and medically treated primary hypertension undergoing antihypertensive medication.ResultsStatistical analysis was carried out based on the data of 28 primary hypertensive patients (seven females, 21 males, mean age ± SD: 49.8 ± 7.8 years mean; clinic blood pressure: mean systolic blood pressure: 137.2 ± 13.1 mmHg, mean diastolic blood pressure: 82.1 ± 9.9 mmHg). Mean duration of hypertension in the sample was 13.1 years (±8.2 years). Correlations among the main variables of interest showed a positive and significant relationship between emotional dysregulation indexes, psychological distress, and self‐care domains: awareness resulted negatively and significantly correlated to self‐efficacy; nonacceptance, goals and impulse indexes seemed positively and significantly correlated to anxiety and depression; finally, stress was correlated positively and significantly to awareness and impulse.ConclusionsEvidencing the role of emotion dysregulation on self‐care skills and psychological outcomes, and specifically highlighting the impact of emotion dysregulation on self‐care, our findings could inform the development and implementation of psychological interventions aimed at promoting psychological well‐being and healthy behavior by focusing on the promotion of emotion regulation strategies, to reduce the risk for co‐morbidity and/or severe cardiovascular diseases.
Recent Advances in Mitochondria‐Localized Luminescent Ruthenium(II) Metallodrugs as Anticancer Agents
Authors: Patra Sushree Aradhana , Sahu Gurunath , Das Sanchita , Dinda Rupam 
Published: September 2023

AbstractPresently, the most effective way to transport drugs specifically to mitochondria inside the cells is of pharmacophoric interest, as mitochondria are recognized as one of the most important targets for new drug design in cancer diagnosis. To date, there are many reviews covering the photophysical, photochemical, and anticancer properties of ruthenium(II) based metallodrugs owing to their high interest in biological applications. There are, however, no reviews specifically covering the mitochondria‐localized luminescent Ru(II) complexes and their subsequent mitochondria‐mediated anticancer activities. Therefore, this review describes the physicochemical basis for the mitochondrial accumulation of ruthenium complexes, their synthetic strategies to localize and monitor the mitochondria in living cells, and their related underlying anticancer results. Finally, we review the related areas from previous works describing the mitochondria‐localized ruthenium complexes for the treatment of cancer‐related diseases. Along with this, we also deliberate the perspectives and future directions for emerging more bifunctional Ru(II) complexes that can target, image, and kill tumors more efficiently in comparison with the existing mitochondria‐targeted cancer therapeutics.
Effects of Omeprazole and Verapamil on the Pharmacokinetics, Safety, and Tolerability of Mavacamten: Two Drug–Drug Interaction Studies in Healthy Participants
Authors: Perera Vidya , Gretler Daniel D. , Seroogy Julie D. , Chiang Manting , Palmisano Maria , Florea Victoria 
Published: September 2023

AbstractTwo open‐label, Phase 1 studies assessed the effects of omeprazole (a weak to moderate cytochrome P450 [CYP] 2C19 inhibitor) and verapamil (a moderate CYP3A4 inhibitor) on the pharmacokinetics, safety, and tolerability of mavacamten. In the omeprazole study, healthy participants received mavacamten 15 mg alone or with a 31‐day course of omeprazole 20 mg once daily. In the verapamil study, healthy participants received mavacamten 25 mg alone or with a 28‐day course of verapamil 240 mg once daily. In the omeprazole study, 27 of 29 randomized participants completed the study. Nine participants receiving mavacamten alone were normal metabolizers (NMs) of CYP2C19 substrates, and 6 were rapid metabolizers; 8 NMs and 6 rapid metabolizers received mavacamten + omeprazole. In both studies, mavacamten showed no safety signals and was generally well tolerated. Overall mavacamten exposure (area under the plasma concentration–time curve) increased by approximately 50% with omeprazole coadministration; maximum observed concentration (Cmax), time to Cmax, and elimination half‐life were not affected appreciably. In the verapamil study, 25 of 26 randomized participants received the study drug(s) and were included in the pharmacokinetic analyses; 24 completed the study. In the pharmacokinetic population, 12 participants received mavacamten alone (11 NMs, 1 poor metabolizer) and 13 received mavacamten + verapamil (7 NMs, 4 intermediate metabolizers, 2 poor metabolizers). Following verapamil coadministration in NMs and intermediate metabolizers, mavacamten area under the plasma concentration–time curve was minimally increased (by less than 20%), and Cmax was modestly increased (by 52%). These results suggest that mavacamten can be coadministered with weak CYP2C19 and moderate CYP3A4 inhibitors.