bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoding the multifaceted signatures and transcriptomic characteristics of stem cells derived from apical papilla and dental pulp of human supernumerary teeth
Authors: Ning Juan , Zhang Leisheng , Xie Hanjing , Chai Lian , Yao Jun 
Published: August 2023

AbstractSupernumerary teeth are advantaged sources for high‐quality stem cell preparation from both apical papilla (SCAP‐Ss) and dental pulp (DPSCs). However, the deficiency of the systematic and detailed comparison of the biological and transcriptomic characteristics of the aforementioned stem cells largely hinders their application in regenerative medicine. Herein, we collected supernumerary teeth for SCAP‐S and DPSC isolation and identification by utilizing multiple biological tests (e.g., growth curve, cell cycle and apoptosis, adipogenic and osteogenic differentiation, and quantitative real‐time polymerase chain reaction). Furthermore, we took advantage of transcriptome sequencing and multifaceted bioinformatic analyses to dissect the similarities and diversities between them. In this study, we found that SCAP‐Ss and DPSCs showed indistinctive signatures in morphology and immunophenotypes, whereas with diversity in cell vitality and multi‐lineage differentiation as well as gene expression profiling and differentially expressed genes‐associated gene ontology and signaling pathways. Collectively, our data indicated the diversity of the multifaceted signatures of human supernumerary teeth‐derived stem cells both at the cellular and molecular levels, which also supplied new references for SCAP‐Ss serving as splendid alternative stem cell sources for regenerative medicine purposes.
Tubercular meningitis and cortical venous thrombosis: A rare but potentially lethal combination—A case report and literature review
Authors: Mehta Kahan , Chandrani Naazmin , Shah Ishani , Mehta Samir , Omar Mohamed A. 
Published: August 2023

Key Clinical MessageCortical venous thrombosis is a rare but severe complication of TBM that requires a high index of suspicion for early diagnosis. The treatment of CVT in TBM is based on anticoagulant therapy, which is known to improve the outcomes of the patients.AbstractThe case report describes an 18‐year‐old male in India with symptoms of tubercular meningitis complicated by cortical venous thrombosis. Tubercular meningitis is a rare but severe form of meningitis caused by tuberculosis bacteria and is a significant public health concern in India. The patient presented to the emergency department with a history of fever, headache, and vomiting for the past month, with a positive Mycobacterium tuberculosis test. The patient was started on standard antitubercular therapy and was diagnosed with cortical venous thrombosis via an MRI scan. Treatment included antitubercular therapy, anticoagulation therapy, dexamethasone, and antiemetic drugs. The patient's symptoms improved over 2 weeks of therapy. The case highlights the importance of early detection, treatment, and prevention strategies, such as the National Tuberculosis elimination program, in controlling the spread of tuberculosis in India. It also emphasizes the importance of close monitoring for complications in patients with tubercular meningitis, such as cortical venous thrombosis, which can be life‐threatening.
Thermomechanical Modeling of the Stabilization Process for Carbon Fiber Production
Authors: Wolf Jan , Peters Romy , Mädler Jonathan , Wolz Daniel S. , Behnisch Thomas , Sadeghi Bogar Mohsen , Urbas Leon , Gude Maik 
Published: August 2023

AbstractWithin carbon fiber manufacturing, the stabilization process is the most time‐ and energy‐intensive process due to the complexity of chemical structure transformation. Therefore, optimization is strictly required to enable cost‐efficient stabilization processes. For the first time, a hybrid semi‐parametric model for continuous stabilization is developed to prognose stabilization progress and density of the stabilized fiber. The proposed model takes the process parameters like dwell time, stabilization temperature, and fiber stretching as well as precursor properties, such as fiber density, into account. Finally, the proposed hybrid semi‐parametric model offers a novel plant‐transferable optimization solution for model‐based energy optimization in the stabilization process.
Optimizing 3d spin polarization of CoOOH by in situ Mo doping for efficient oxygen evolution reaction
Authors: Jia Zhichao , Yuan Yang , Zhang Yanxing , Lyu Xiang , Liu Chenhong , Yang Xiaoli , Bai Zhengyu , Wang Haijiang , Yang Lin 
Published: August 2023

AbstractTransition‐metal oxyhydroxides are attractive catalysts for oxygen evolution reactions (OERs). Further studies for developing transition‐metal oxyhydroxide catalysts and understanding their catalytic mechanisms will benefit their quick transition to the next catalysts. Herein, Mo‐doped CoOOH was designed as a high‐performance model electrocatalyst with durability for 20 h at 10 mA cm−2. Additionally, it had an overpotential of 260 mV (glassy carbon) or 215 mV (nickel foam), which was 78 mV lower than that of IrO2 (338 mV). In situ, Raman spectroscopy revealed the transformation process of CoOOH. Calculations using the density functional theory showed that during OER, doped Mo increased the spin‐up density of states and shrank the spin‐down bandgap of the 3d orbits in the reconstructed CoOOH under the electrochemical activation process, which simultaneously optimized the adsorption and electron conduction of oxygen‐related intermediates on Co sites and lowered the OER overpotentials. Our research provides new insights into the methodical planning of the creation of transition‐metal oxyhydroxide OER catalysts.
Mg‐doped, carbon‐coated, and prelithiated SiOx as anode materials with improved initial Coulombic efficiency for lithium‐ion batteries
Authors: Liu Bin , Liu Jie , Zhong Cheng , Hu Wenbin 
Published: August 2023

AbstractSilicon suboxide (SiOx, x ≈ 1) is promising in serving as an anode material for lithium‐ion batteries with high capacity, but it has a low initial Coulombic efficiency (ICE) due to the irreversible formation of lithium silicates during the first cycle. In this work, we modify SiOx by solid‐phase Mg doping reaction using low‐cost Mg powder as a reducing agent. We show that Mg reduces SiO2 in SiOx to Si and forms MgSiO3 or Mg2SiO4. The MgSiO3 or Mg2SiO4 are mainly distributed on the surface of SiOx, which suppresses the irreversible lithium‐ion loss and enhances the ICE of SiOx. However, the formation of MgSiO3 or Mg2SiO4 also sacrifices the capacity of SiOx. Therefore, by controlling the reaction process between Mg and SiOx, we can tune the phase composition, proportion, and morphology of the Mg‐doped SiOx and manipulate the performance. We obtain samples with a capacity of 1226 mAh g–1 and an ICE of 84.12%, which show significant improvement over carbon‐coated SiOx without Mg doping. By the synergistical modification of both Mg doping and prelithiation, the capacity of SiOx is further increased to 1477 mAh g–1 with a minimal compromise in the ICE (83.77%).
Tailoring the CO2 Hydrogenation Performance of Fe‐Based Catalyst via Unique Confinement Effect of the Carbon Shell
Authors: He Ruosong , Wang Yang , Li Meng , Liu Jianxin , Gu Yongqiang , Wang Wenhang , Liu Qiang , Tsubaki Noritatsu , Wu Mingbo 
Published: August 2023

AbstractEven though Fe‐based catalysts have been widely employed for CO2 hydrogenation into hydrocarbons, oxygenates, liquid fuels, etc., the precise regulation of their physicochemical properties is needed to enhance the catalytic performance. Herein, under the guidance of the traditional concept in heterogeneous catalysis‐confinement effect, a core‐shell structured catalyst Na−Fe3O4@C is constructed to boost the CO2 hydrogenation performance. Benefiting from the carbon‐chain growth limitation, tailorable H2/CO2 ratio on the catalytic interface, and unique electronic property that all endowed by the confinement effect, the selectivity and space‐time yield of light olefins (C2=−C4=) are as high as 47.4 % and 15.9 g molFe−1 h−1, respectively, which are all notably higher than that from the shell‐less counterpart. The function mechanism of the confinement effect in Fe‐based catalysts are clarified in detail by multiple characterization and density functional theory (DFT). This work may offer a new prospect for the rational design of CO2 hydrogenation catalyst.
Oxidative Addition and β‐Hydride Elimination by a Macrocyclic Dinickel Complex: Observing Bimetallic Elementary Reactions
Authors: Delaney Andie R , Kroeger Asja A , Coote Michelle L , Colebatch Annie L 
Published: August 2023

AbstractThe dinickel(I) complex Ni2(tBuPONNOPONNO), featuring a planar macrocyclic diphosphoranide ligand tBuPONNOPONNO, offers a unique architectural platform for observing bimetallic elementary reactions. Oxidative addition reactions of alkyl halides produce dinickel(II) complexes of the type Ni2(μ‐R)(μ‐X)(tBuPONNOPONNO). However, when R=Et β‐hydride elimination is observed to form a dinickel monohydride, with the rate dependent on the nature of X. DFT studies suggest a new mechanism for bimetallic β‐hydride elimination, where the rate dependence arises from the steric pressure imposed by the X group on the opposing trans face of the dinickel macrocycle. This work enhances understanding of bimetallic elementary reactions, particularly β‐hydride elimination, which have not been well‐explored for dinuclear systems.
Bioinspired Non‐Heme Mn Catalysts for Regio‐ and Stereoselective Oxyfunctionalizations with H2O2
Authors: Ottenbacher Roman V. , Bryliakova Anna A. , Kurganskii Vladimir I. , Prikhodchenko Petr V. , Medvedev Alexander G. , Bryliakov Konstantin P. 
Published: August 2023

AbstractIn recent years, metalloenzymes‐mediated highly selective oxidations of organic substrates under mild conditions have been inspiration for developing synthetic bioinspired catalyst systems, capable of conducting such processes in the laboratory (and, in the future, in industry), relying on easy‐to‐handle and environmentally benign oxidants such as H2O2. To date, non‐heme manganese complexes with chiral bis‐amino‐bis‐pyridylmethyl and structurally related ligands are considered as possessing the highest synthetic potential, having demonstrated the ability to mediate a variety of chemo‐ and stereoselective oxidative transformations, such as epoxidations, C(sp3)‐H hydroxylations and ketonizations, oxidative desymmetrizations, kinetic resolutions, etc. Furthermore, in the past few years non‐heme Mn based catalysts have become the major platform for studies focused on getting insight into the molecular mechanisms of oxidant activation and (stereo)selective oxygen transfer, testing non‐traditional hydroperoxide oxidants, engineering catalytic sites with enzyme‐like substrate recognition‐based selectivity, exploration of catalytic regioselectivity trends in the oxidation of biologically active substrates of natural origin. This contribution summarizes the progress in manganese catalyzed C‐H oxygenative transformations of organic substrates, achieved essentially in the past 5 years (late 2018–2023).
A review of Znln2S4‐based photocatalysts for producing hydrogen by water splitting under visible light: Fundamentals and recent advancements
Authors: Mia Nasim , Singh Kuljeet , Polson James , Lisi Luciano , Willemsen Evan , Hu Yulin 
Published: August 2023

AbstractHydrogen (H2) is a clean energy carrier widely used in oil refineries, fertilizers, chemicals, and steel manufacturing. Presently, the majority of H2 is produced from either steam methane reforming of natural gas or coal gasification; however, these technologies result in a massive amount of CO2 emission. Alternatively, the use of photocatalysts for producing H2 via water splitting is an eco‐friendly and sustainable approach, among which the selection of highly efficient, stable, and cheap photocatalysts is the key. In this review, Znln2S4‐based photocatalysts are thoroughly described in terms of the fundamentals and thermodynamics of water splitting, fabrication methods, and different heterostructure photocatalytic systems. After this, recent developments in the large‐scale implementation of photocatalytic reactors are discussed. Finally, a summary of future research directions and major conclusions is provided. With proper modification, such as heterojunction systems and the selection of proper fabrication methods, Znln2S4‐based photocatalysts could be superior materials for water splitting. In short, this review article could offer meaningful and useful insights and guidance for the development of Znln2S4‐based photocatalysts in water splitting for producing H2 under visible light.
Interfacial dilatational rheology and displacement mechanism of nano‐flooding system
Authors: Guowei Qin , Yong Liu , Qingping Liu , Saisai Sun , Feng Liu , Wenlong Qin , Xiao Wang 
Published: August 2023

AbstractIn the field of crude oil extraction, nano‐flooding technology can significantly improve the oil displacement efficiency and provide important technical support for tertiary oil recovery. Although a host of studies have been carried out in this domain, its dilatational rheology and displacement mechanism are rarely reported. In order to address this gap in the extant literature, as a crucial component of this investigation, the interfacial rheology of the nano‐flooding system and the simulated crude oil was systematically studied with the aid of the JMP2000A interface expansion rheometer. Meanwhile, a micro‐displacement experiment was carried out to elucidate its displacement mechanism. The obtained results show that the nano‐flooding system initially increases as its concentration, solution pH, and aging time increase, after which a decline is observed. However, with the change of salinity, it shows a trend of increasing first and then decreasing. Moreover, according to the multi‐factor test results yielded by the relevant software, the relative error is less than 5%, which fully meets the needs of the field and provides an important basis for the field construction. The findings further suggest that the modulus between the nano‐flooding system and the simulated crude oil can be increased by 84‐fold (i.e., from 0.9271 to 78.0739 mN/m). In addition, during the displacement process, the fingering phenomenon of the displacement fluid can be reduced via piston‐like displacement. The swept volume also improves the oil washing efficiency of crude oil, demonstrating that the proposed strategy achieves the purpose of enhancing oil recovery.
Synthesis of Quinazolin‐2,4,6‐triamine Derivatives as Non‐purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**
Authors: Lopez‐Sanchez Marcela A. , del Carmen Garcia‐Rodriguez María , Aguayo‐Ortiz Rodrigo , Hernandez‐Cruz Estefani , Figueroa‐Figueroa Diego I. , Hernandez‐Luis Francisco 
Published: August 2023

AbstractIn this work, a new set of quinazolin‐2,4,6‐triamine derivatives were synthesized to explore their potential biological activity as xanthine oxidase (XO) inhibitors, superoxide scavengers and screening of their toxicological profile. Among all the synthesized compounds, B1 exhibited better inhibitory activity against bovine xanthine oxidase (bXO) than allopurinol (IC50=1.56 μM and IC50=6.99 μM, respectively). As superoxide scavengers, B1, B2 and B13 exhibited a better effect than allopurinol (97.3 %, 82.1 %, 87.4 % and 69.4 %, respectively). Regarding the toxicological profile, B1 was less cytotoxic than methotrexate on HCT‐15 cancer cells. Apoptosis results obtained in cells of female and male mice, showed that B1 and B2 presented a similar behaviour to CrO3 (positive control) with respect to the average frequency to induce apoptosis; while B13 apoptosis induced effect was similar to DMSO and control group. Finally, B1, B2, B13 did not induce genotoxicity in a micronuclei murine model compared to CrO3.
A cost‐effectiveness analysis of avelumab plus best supportive care versus best supportive care alone as first‐line maintenance treatment for patients with locally advanced or metastatic urothelial carcinoma in Taiwan
Authors: Su Po‐Jung , Xiao Ying , Lin Amy Y. , Goh Connie , Wu Ethan , Liu Kevin , Chou Patrick , Kuo Kaitlin , Palencia Roberto , Chang Jane , Kearney Mairead , Kapetanakis Venediktos , Benedict Agnes 
Published: August 2023

AbstractBackgroundPatients with locally advanced or metastatic urothelial carcinoma have limited treatment options and a poor prognosis. The JAVELIN Bladder 100 trial showed that avelumab as first‐line maintenance plus best supportive care significantly prolonged overall survival and progression‐free survival versus best supportive care alone in patients with locally advanced or metastatic urothelial carcinoma that had not progressed with first‐line platinum‐containing chemotherapy.AimsWe assessed whether avelumab plus best supportive care is a cost‐effective treatment option versus best supportive care alone in this patient group in Taiwan.Methods and ResultsA partitioned survival model was used to estimate the costs and effects of avelumab plus best supportive care versus best supportive care alone over a 20‐year time horizon from the perspective of Taiwan's National Health Insurance Administration. Patient‐level data from JAVELIN Bladder 100 on efficacy, safety, utility, and time on treatment were analyzed to provide parameters for the model. Log‐normal and Weibull distributions were used for overall survival and progression‐free survival, respectively. Costs of healthcare resources, drug acquisition, adverse events, and progression were identified through publicly available data sources and clinician interviews. The model estimated total costs, life years, and quality‐adjusted life years. In the modeled base case, avelumab plus best supportive care increased survival versus best supportive care alone by 0.79 life years (2.93 vs. 2.14) and 0.61 quality‐adjusted life years (2.15 vs. 1.54). The incremental cost‐effectiveness ratio for avelumab plus best supportive care versus best supportive care alone was NT$1 827 680. Most (78%) of the probabilistic sensitivity analyses fell below three times the gross domestic product per capita. Scenario analysis indicated that life year and quality‐adjusted life year gains were most sensitive to alternative survival extrapolations for both avelumab plus best supportive care and best supportive care alone.ConclusionAvelumab first‐line maintenance therapy combined with best supportive care was determined as a cost‐effective treatment strategy for patients in Taiwan diagnosed with locally advanced or metastatic urothelial carcinoma that had not progressed with platinum‐containing chemotherapy.
Platinum‐DNA Origami Hybrid Structures in Concentrated Hydrogen Peroxide
Authors: Alarcón‐Correa Mariana , Kilwing Luzia , Peter Florian , Liedl Tim , Fischer Peer 
Published: August 2023

AbstractThe DNA origami technique allows fast and large‐scale production of DNA nanostructures that stand out with an accurate addressability of their anchor points. This enables the precise organization of guest molecules on the surfaces and results in diverse functionalities. However, the compatibility of DNA origami structures with catalytically active matter, a promising pathway to realize autonomous DNA machines, has so far been tested only in the context of bio‐enzymatic activity, but not in chemically harsh reaction conditions. The latter are often required for catalytic processes involving high‐energy fuels. Here, we provide proof‐of‐concept data showing that DNA origami structures are stable in 5 % hydrogen peroxide solutions over the course of at least three days. We report a protocol to couple these to platinum nanoparticles and show catalytic activity of the hybrid structures. We suggest that the presented hybrid structures are suitable to realize catalytic nanomachines combined with precisely engineered DNA nanostructures.
Transmembrane Transporter Constructed from PlatinumMetal‐organic Cage
Authors: Hu Xinyu , Yue Bangkun , Chen Chen , Zong Wei , Li Sisi , Yang Haishen , Hou Yali , Zhang Jian 
Published: August 2023

AbstractA perylene diimide‐based metal‐organic cage (MOC4c) was found to be an efficient transmembrane transporter for ions and small molecules through the internal cavity of the cage. MOC4c could selectively transport different anions, as evidenced by vesicle‐based fluorescenceassays and planar lipid bilayer‐based current recordings.Furthermore, MOC4c appears tofacilitate calcein transport across the lipid bilayer membrane of a livingcell, suggesting that MOC4c could be used as a biologicaltool for small molecule drugstransmembrane transportation.
The effectiveness of individual schema therapy in older adults with borderline personality disorder: A multiple‐baseline case series design
Authors: Khasho David A. , van Alphen Sebastiaan P. J. , Ouwens Machteld A. , Arntz Arnoud , Heijnen‐Kohl Sylvia M. J. , Videler Arjan C. 
Published: August 2023

AbstractObjectiveThe aim of this study was to explore the effectiveness of schema therapy (ST) in older adults with borderline personality disorder (BPD).MethodsMultiple baseline case series design with five BPD patients, with a mean age of 66. After a baseline phase with random length, patients received weekly ST sessions for a year, followed by follow‐up sessions during 6 months. Participants rated the credibility of negative core beliefs weekly; various secondary outcome measures were assessed every 6 months (severity of BPD, early maladaptive schemas, schema modes, personality functioning, maladaptive personality traits, psychological distress and quality of life), and BPD diagnosis was assessed before baseline and after follow‐up. Data were analysed with mixed regression analyses and paired t‐tests.ResultsResults revealed that ST led to a significant decrease in credibility of negative core beliefs, with high effect sizes. All participants remitted from their BPD diagnosis.ConclusionThis is the first study exploring the effectiveness of ST for BPD in older adults, and it suggests that ST can be a powerful intervention for this group of patients.
The effect of extended cold storage on the functional quality attributes of different potato genotypes
Authors: Tlili Imen , Ilahy Riadh , Ghannem Samir , Romdhane Leila , Mohamed Hatem Ben , Pék Zoltán , Siddiqui Mohammed Wasim , Helyes Lajos , Takács Sándor , Lenucci Marcello Salvatore , Khamassy Nouri 
Published: August 2023

AbstractPotato (Solanum tuberosum L.) is a staple food widely consumed in Tunisia and represents a source of various secondary metabolites with human health benefits. However, cold storage of potato tuber affects their bioactive properties and functional quality. Despite the importance of this fact, few studies have examined the effects of extended cold storage on potato tubers quality. Therefore, the objective of the present work was to evaluate the effect of cold storage on the main quality traits of different potato genotypes grown in Tunisia. This investigation focused on four cultivated potato varieties including three commercial (Selena, Elbeidha, and Naima) and a selected clone CL27 grown under late cropping season conditions with planting at the beginning of autumn and a winter tuberization. The tubers from this trial were stored for 90 days at 8°C. The results obtained showed that quality traits of potato tubers were strongly influenced by storage at 8°C throughout 90 days. Additionally, disregarding the genotype, total carotenoids, phenolics, and flavonoids contents increased significantly following 90 days storage at 8°C. However, genotypic differences underlying the antioxidant activity in both hydrophilic and lipophilic fractions were detected suggesting their sensibility to cold storage. This study might be useful for breeders working on potato genotypes suitable for extended storage duration and for growers storing their material for extended period under low temperature.