bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics combined with transcriptomics to predict response to immunotherapy from patients treated with PD-1/PD-L1 inhibitors for advanced NSCLC
Authors: Bouhamama Amine , Leporq Benjamin , Faraz Khuram , Foy Jean-Philippe , Boussageon Maxime , Pérol Maurice , Ortiz-Cuaran Sandra , Ghiringhelli François , Saintigny Pierre , Beuf Olivier , Pilleul Frank 
Published: May 2023

IntroductionIn this study, we aim to build radiomics and multiomics models based on transcriptomics and radiomics to predict the response from patients treated with the PD-L1 inhibitor.Materials and methodsOne hundred and ninety-five patients treated with PD-1/PD-L1 inhibitors were included. For all patients, 342 radiomic features were extracted from pretreatment computed tomography scans. The training set was built with 110 patients treated at the Léon Bérard Cancer Center. An independent validation cohort was built with the 85 patients treated in Dijon. The two sets were dichotomized into two classes, patients with disease control and those considered non-responders, in order to predict the disease control at 3 months. Various models were trained with different feature selection methods, and different classifiers were evaluated to build the models. In a second exploratory step, we used transcriptomics to enrich the database and develop a multiomic signature of response to immunotherapy in a 54-patient subgroup. Finally, we considered the HOT/COLD status. We first trained a radiomic model to predict the HOT/COLD status and then prototyped a hybrid model integrating radiomics and the HOT/COLD status to predict the response to immunotherapy.ResultsRadiomic signature for 3 months’ progression-free survival (PFS) classification: The most predictive model had an area under the receiver operating characteristic curve (AUROC) of 0.94 on the training set and 0.65 on the external validation set. This model was obtained with the t-test selection method and with a support vector machine (SVM) classifier. Multiomic signature for PFS classification: The most predictive model had an AUROC of 0.95 on the training set and 0.99 on the validation set. Radiomic model to predict the HOT/COLD status: the most predictive model had an AUROC of 0.93 on the training set and 0.86 on the validation set. HOT/COLD radiomic hybrid model for PFS classification: the most predictive model had an AUROC of 0.93 on the training set and 0.90 on the validation set.ConclusionIn conclusion, radiomics could be used to predict the response to immunotherapy in non-small-cell lung cancer patients. The use of transcriptomics or the HOT/COLD status, together with radiomics, may improve the working of the prediction models.
The effectiveness of pre-contoured titanium alloy rods in inducing thoracic kyphosis after sequential spinal releases in an in vitro biomechanical model
Authors: Shi Jinhui , Ordway Nathaniel R. , Sun Mike H. , Albanese Stephen A. , Lavelle William F. 
Published: May 2023

PurposeEvaluate the ability of pre-contoured rods to induce thoracic kyphosis (TK) in human cadaveric spines and determine the effectiveness of sequential surgical adolescent idiopathic scoliosis (AIS) release procedures.MethodsSix thoracolumbar (T3-L2) spine specimens were instrumented with pedicle screws bilaterally (T4–T12). Over correction using pre-contoured rods was performed for intact condition and Cobb angle was measured. Rod radius of curvature (RoC) was measured pre- and post-reduction. The process was repeated following sequential release procedures of (1) interspinous and supraspinous ligaments (ISL); (2) ligamentum flavum; (3) Ponte osteotomy; (4) posterior longitudinal ligament (PLL); and (5) transforaminal discectomy. Cobb measurements determined the effective contribution of release on TK and RoC data displayed effects of reduction to the rods.ResultsThe intact TK (T4–12) was 38.0° and increased to 51.7° with rod reduction and over correction. Each release resulted in 5°–7°of additional kyphosis; the largest releases were ISL and PLL. All releases resulted in significant increases in kyphosis compared to intact with rod reduction and over correction. Regionally, kyphosis increased ∼2° for each region following successive releases. Comparing RoC before and after reduction showed significant 6° loss in rod curvature independent of release type.ConclusionKyphosis increased in the thoracic spine using pre-contoured and over corrected rods. Subsequent posterior releases provided a substantial, meaningful clinical change in the ability to induce additional kyphosis. Regardless of the number of releases, the ability of the rods to induce and over correct kyphosis was reduced following reduction.
Feasibility and safety of a self-developed sleeve for the endoscopic removal of refractory foreign body incarceration
Authors: Yu Guangqiu , Li Li , Zhang Yirui , Zhong Xiaohuan , Wang Jing , Jiang Ling , Hu Duanmin , Zhou Weixia 
Published: May 2023

ObjectiveThis study aimed to assess the feasibility and safety of a novel self-designed sleeve for the endoscopic removal of a refractory incarcerated foreign body in the upper gastrointestinal tract (UGIT).MethodsAn interventional study was conducted between June and December 2022. A total of 60 patients who underwent an endoscopic removal of a refractory incarcerated foreign body from the UGIT were randomly allocated to the self-developed sleeve and the conventional transparent cap. The study evaluated and compared the operation time, successful removal rate, new injury length at the entrance of the esophagus, new injury length at the impaction site, visual field clarity, and postoperative complications between the two groups.ResultsThe success rates of the two cohorts in the foreign body removal display no significant discrepancy (100% vs. 93%, P = 0.529). Nevertheless, the methodology of the novel overtube-assisted endoscopic foreign body removal has culminated in a significant reduction in the removal duration [40 (10, 50) min vs. 80 (10, 90) min, P = 0.01], reduction in esophageal entrance traumas [0 (0, 0) mm vs. 4.0 (0, 6) mm, P &lt; 0.001], mitigation of injuries at the location of the foreign body incarceration [0 (0, 2) mm vs. 6.0 (3, 8) mm, P &lt; 0.001], an enhanced visual field (P &lt; 0.001), and a decrement in postoperative mucosal bleeding (23% vs. 67%, P &lt; 0.001). The self-developed sleeve effectively negated the advantages of incarceration exclusion during removal.ConclusionThe study findings support the feasibility and safety of the self-developed sleeve for the endoscopic removal of a refractory incarcerated foreign body in the UGIT, with advantages over the conventional transparent cap.
Multiple potential recombination events among Newcastle disease virus genomes in China between 1946 and 2020
Authors: Bahoussi Amina Nawal , Shah Pir Tariq , Zhao Jia-Qi , Wang Pei-Hua , Guo Yan-Yan , Wu Changxin , Xing Li 
Published: May 2023

IntroductionNewcastle Disease Virus (NDV) is a highly adaptable virus with large genetic diversity that has been widely studied for its oncolytic activities and potential as a vector vaccine. This study investigated the molecular characteristics of 517 complete NDV strains collected from 26 provinces across China between 1946-2020.MethodsHerein, phylogenetic, phylogeographic network, recombination, and amino acid variability analyses were performed to reveal the evolutionary characteristics of NDV in China.Results and discussionsPhylogenetic analysis revealed the existence of two major groups: GI, which comprises a single genotype Ib, and GII group encompassing eight genotypes (I, II, III, VI. VII. VIII, IX and XII). The Ib genotype is found to dominate China (34%), particularly South and East China, followed by VII (24%) and VI (22%). NDV strains from the two identified groups exhibited great dissimilarities at the nucleotide level of phosphoprotein (P), matrix protein (M), fusion protein (F), and haemagglutinin-neuraminidase (HN) genes. Consistently, the phylogeographic network analysis revealed two main Network Clusters linked to a possible ancestral node from Hunan (strain MH289846.1). Importantly, we identified 34 potential recombination events that involved mostly strains from VII and Ib genotypes. A recombinant of genotype XII isolated in 2019 seems to emerge newly in Southern China. Further, the vaccine strains are found to be highly involved in potential recombination. Therefore, since the influence of recombination on NDV virulence cannot be predicted, this report’s findings need to be considered for the security of NDV oncolytic application and the safety of NDV live attenuated vaccines.
Primary care micro-teams: an international systematic review of patient and healthcare professional perspectives
Authors: Coombs Charles , Cohen Tanya , Duddy Claire , Mahtani Kamal R , Owen Emily , Roberts Nia , Saini Aman , Foster Alexander Staddon , Park Sophie 
Published: May 2023

BackgroundInternational trends have shifted to creating large general practices. There is an assumption that interdisciplinary teams will increase patient accessibility and provide more cost-effective, efficient services. Micro-teams have been proposed to mitigate for some potential challenges of practice expansion, including continuity of care.AimTo review available literature and examine how micro-teams are described, and identify opportunities and limitations for patients and practice staff.Design and settingThis was an international systematic review of studies published in English.MethodDatabases (MEDLINE, EMBASE, CINAHL, Cochrane Library, and Scopus) and grey literature were searched. Studies were included if they provided evidence about implementation of primary care micro-teams. Framework analysis was used to synthesise identified literature. The research team included a public contributor co-applicant. The authors conducted stakeholder discussions with those with and without experience of micro-team implementation.ResultsOf the 462 studies identified, 24 documents met the inclusion criteria. Most included empirical data from healthcare professionals, describing micro-team implementation. Results included characteristics of the literature; micro-team description; range of ways micro-teams have been implemented; reported outcomes; and experiences of patients and staff.ConclusionThe organisation of primary care has potential impact on the nature and quality of patient care, safety, and outcomes. This review contributes to current debate about care delivery and how this can impact on the experiences and outcomes of patients and staff. This analysis identifies several key opportunities and challenges for future research, policy, and practice.
Plan de Responsabilidad Social Empresarial de una corporación minera
Authors: Córdova Acosta Edcel Antonio , Borrero Carrasco Gabriel Ernesto , Sánchez García Ingrid Estefani , Agurto Cano Vanessa del Carmen , Rivera Calle Omar 
Published: May 2023

La práctica de la minería trae consigo conflictos de intereses con las comunidades en las cuales desarrollan sus procesos. La Responsabilidad Social Empresarial (RSE) de la corporación minera, en Perú, se convierte en la fórmula mediante la cual la comunidad, el Estado y la empresa minera puedan interactuar y lograr relaciones sostenibles, responsables y positivas con el fin de reducir el clima de conflicto; así como también contribuir a mejorar la calidad de vida de las personas. Este artículo presenta las características de un Plan de Responsabilidad Social Empresarial (PRSE) para atender las necesidades detectadas en 25 trabajadores de una corporación minera y 75 miembros de la comunidad aledaña en la cual ejecuta sus actividades la corporación. Los resultados muestran que los trabajadores consideran la necesidad de mayor capacitación y la comunidad manifiesta su interés por mejorar la calidad de vida a través del apoyo a los aspectos educativos. El PRSE se caracteriza por el desarrollo de las fases de planificación, ejecución, monitoreo y evaluación, cada una de ellas con sus objetivos, responsables y lapsos de duración. Este plan permite realizar actividades más efectivas para generar vínculos entre las compañías mineras, los grupos de interés o stakeholders y las comunidades.
Análise dos metabólitos secundários da aroeira: prospecção qualitativa da casca e semente
Authors: Leite Renan Rodrigues , Aragão Emily Francisca de Souza , De Barros Neuza Biguinati , Barros Rogelio Rocha 
Published: May 2023

Este projeto visa identificar os metabólitos secundários da planta Schinus terebinthifolius Raddi. Buscar informações a respeito de suas finalidades, bem como despertar novos interesses sobre plantas utilizadas pela população como medicina alternativa. Trabalho realizado no laboratório de pesquisa do CENTRO UNIVERSITÁRIO – FIMCA, Porto Velho - RO. As prospecções foram realizadas no mês de setembro de 2022. No desenvolvimento da pesquisa foram utilizados: laboratório, artigos científicos, teses, sites, livros e revistas especializadas no tema. Nota-se que tanto as sementes quanto o pó da casca apresentaram uma quantidade expressiva de metabólitos secundários. Através da prospecção fitoquímica da semente e pó da casca, os testes foram positivos para alcaloides, glicosídeos cardiotônicos, cumarinas, flavonoides, taninos e triterpenos. Sendo assim, sugere-se que as possíveis ações terapêuticas desta espécie, sejam direcionadas por estes metabólitos secundários. Nesta pesquisa foi possível conferir que, tanto a semente macerada quanto o pó da casca da planta S. terebinthifolius Raddi, no seu extrato etanólico, possuem resultados positivos para alcaloides, glicosídeos cardiotônicos, cumarinas, flavonoides, taninos e triterpenos. Por fim destaca-se que este modelo de estudo e pesquisa possui importância para contribuir com o conhecimento da população a respeito de plantas medicinais. Contudo, procedimentos fitoquímicos mais específicos são necessários para que os compostos de interesse sejam elucidados em análises de cunho farmacológico, que muito podem contribuir para a descoberta, validação e utilização destes na terapêutica.
The Methodology of Delayed Interaction Techniques Application in L2 Asynchronous Learning and Teaching
Authors: Kolisnichenko Anhelina 
Published: May 2023

In the new global education, online learning and teaching have become central issues for different methodology development. This paper examines the ways for asynchronous foreign language teaching mode.
The purpose of this study is to define specific techniques that are applicable to asynchronous interaction in the process of foreign language learning and teaching. The aim of this paper is also to work out the methodology for their use.
Methodology. For this study, a number of research methods were used. The previous studies' analysis was used for the examination of the recent findings. A qualitative case-study experiment was used to investigate personal teachers and students’ experience with delayed interaction techniques (DIT) use in the process of Foreign Language (FL) Methodology teaching and learning that is a component of FL teachers training course in the department of foreign languages of Pavlo Tychyna Uman State Pedagogical University in Ukraine. The methodological approach offered an effective way of compiling delayed interaction technique stages. Data were gathered from the students’ feedback survey that was used as a qualitative method. The online software of the Voyant tool, one of the more practical ways for survey results visualization was applied.
Results. One of the main findings of the current study is a clarification of the delayed interaction technique notion, which is suggested as a definition in the context of the current study issue. The second finding is developing the methodology of using DIT in a second language (L2) asynchronous learning and teaching mode of studying. The methodology includes seven steps for DIT application.
Conclusions. This study has found that generally, interaction is possible to use even asynchronically in conditions that prevent immediate interaction. The results of this study have no limitations for application according to educational institutions, and learners’ age of L2 level. However, for effective DIT applications, it is necessary for teachers and students to have enough digital skills, internet and gadgets access. Further work needs to be done to examine more online resources such as software, apps, and tools for using them in asynchronous L2 learning and teaching.
Entering the Teaching Profession in Slovakia
Authors: Luchenko Olha , Yurchenko Valeriia 
Published: May 2023

The article studies the current state of the teacher induction process in Slovakia, namely the prerequisites for entering the teaching profession. The focus of the current research is the following: the attractiveness of the teaching profession and its influence on the decision-making of future students of pedagogical major, teacher job satisfaction level, the proportion of education requirements for subject knowledge and teaching practice, availability of the profession, the assistance in the search for open positions and vacancies, probation period as a filter to the teaching occupation.
The research aims to determine the problematic aspects of the transition period from student to teacher that need to be addressed to prevent early maladjustment and drop-out in the teaching profession.
Methodology. The research was carried out by applying theoretical and empirical methods. The data were obtained from novice school teachers having conducted an online survey using Google Forms with open and closed questions.
The study’s preliminary results revealed the social image of the teaching profession and components of its attractiveness for future students, problems with the ratio of academic and practical parts in teacher education, possible ways to enter the profession, and the obstacles of the process.
The conducted research allowed us to come to the following conclusions. As a result of the low social image of a teacher, Slovakia is facing a shortage in the profession. The substantial misbalance in initial teacher education in favor of academic knowledge and the absence of specific official requirements for practical experience has subsequences in the quality of school education and early teacher maladjustment. Implementing an open system in the teaching profession is a temporary solution that causes many concerns, especially with the introduction of short-term teachers with low standard requirements in teaching abilities.
Lack of career help for new graduates-teachers throughout their job hunt may cause them to leave the education field. In this situation, adequate support of novice teachers becomes necessary, and the teacher induction program is a subject for future research.
Diagnostic Value of Clinical Activity and Exophthalmus in the Early Diagnosis of Glaucoma in Graves Orbitopathy Patients
Authors: Садовская О.П. , Дравица Л.В. 
Published: May 2023

Цель. Оценить диагностическую значимость активности процесса и протрузии глазных яблок в диагностике симптоматической офтальмогипертензии и вторичной глаукомы. Материалы и методы. Обследовано 175 пациентов (350 глаз и орбит) с различными формами и активностью ЭОП. Из них диагноз впервые выявленной вторичной глаукомы, развившейся на фоне ЭОП, выставлен 30 пациентам (58 глаз и орбит). Результаты и обсуждение. У пациентов с активным течением процесса установлено, что наличие симптоматической офтальмогипертензии прогнозируется при активности процесса, выше или равной 5 баллам (чувствительность (Se) и специфичность (Sp) модели составили 86,7% и 55,9% соответственно), и при экзофтальме, выше или равном 24 мм (чувствительность (Se) и специфичность (Sp) модели составили 78,3% и 85,3% соответственно) (p<0,001). У пациентов с неактивным течением процесса установлено, что наличие вторичной глаукомы прогнозируется при сохранении активности процесса, выше или равной 2 баллам (чувствительность (Se) и специфичность (Sp) модели составили 55,2% и 73,3% соответственно), и при экзофтальме, выше или равном 21 мм (чувствительность (Se) и специфичность (Sp) модели составили 86,2% и 85,0% соответственно) (p<0,001). Заключение. Длительное сохранение активности процесса и протрузии глазных яблок является прогностическим маркером развития глаукомы у пациентов с ЭОП.
Purpose. To assess the diagnostic value of clinical activity and exophthalmus in in the early diagnosis of glaucoma in Graves orbitopathy (GO) patients. Materials and methods. We examined 175 patients (350 eyes and orbits) with different forms and activity of Graves orbitopathy. In 30 patients (58 eyes and orbits) was diagnosed secondary glaucoma. Results and discussions. Determined that the prognostic markers of symptomatic ophthalmohypertension in patients with active stage of GO are the clinical activity score ≥5 points (sensitivity (Se) and specificity (Sp) 86.7% and 55.9%, respectively) and exophthalmus ≥24 mm (sensitivity (Se) and specificity (Sp) 78.3% and 85.3%, respectively) (p<0.001). The prognostic markers of secondary glaucoma in patients with inactive stage of GO are the clinical activity score ≥2 points (sensitivity (Se) and specificity (Sp) 55.2% and 73.3%, respectively) and exophthalmus ≥21 mm (sensitivity (Se) and specificity (Sp) 86.2% and 85.0%, respectively) (p<0.001). Conclusion. Long-term preservation of the clinical activity and exophthalmus are prognostic markers for the development of glaucoma in patients with inactive stage of GO.
On the Issue of Diagnosis of Ocular Manifestations of Hemoblastosis
Authors: Воробьева М.В. 
Published: May 2023

Глазные проявления гемобластозов разнообразны и преимущественно представлены лейкемической инфильтрацией оболочек глаза и гемодинамическими нарушениями в сосудах сетчатки. Лейкемическую инфильтрацию сетчатки необходимо отличать от воспалительного процесса – ретинита, хориоретинита вирусной или грибковой этиологии, нередко развивающегося у гематологических пациентов. Вовлечение в процесс сетчатки в основном наблюдается у взрослых пациентов с острым миелолейкозом, реже у пациентов с острым лимфолейкозом. Ретинопатия чаще возникает при рецидиве заболевания. Описаны случаи, когда глазные симптомы были первым проявлением рецидива заболевания. Ретинопатия может быть и первой манифестацией заболевания. Гемобластоз должен быть включен в дифференциально-диагностический ряд заболеваний, сопровождающихся отеком диска зрительного нерва и ретинальными кровоизлияниями. Характер изменений на глазном дне коррелирует с показателями периферической крови. Ретинопатия и лейкозная оптическая нейропатия являются неблагоприятными прогностическими признаками. Ранняя диагностика и своевременное назначение адекватного лечения полностью нивелируют глазные симптомы и улучшают качество жизни пациентов с гемобластозами.
Ocular manifestations of hemoblastosis are diverse and are mainly represented by leukemic infiltration of the membranes of the eye and hemodynamic disorders in the retinal vessels. Leukemic infiltration of the retina must be distinguished from the inflammatory process – retinitis, chorioretinitis of viral or fungal etiology, often developing in hematological patients. Involvement in the process of the retina is mainly observed in adult patients with acute myeloid leukemia, less often in patients with acute lymphocytic leukemia. Retinopathy occurs more often with a relapse of the disease. Cases are described when ocular symptoms were the first manifestation of a relapse of the disease. Retinopathy may also be the first manifestation of the disease. Hemoblastosis should be included in the differential diagnostic series of diseases accompanied by edema of the optic disc and retinal hemorrhages. The nature of changes in the fundus correlates with peripheral blood parameters. Retinopathy and leukemic optic neuropathy are unfavorable prognostic signs. Early diagnosis and timely appointment of adequate treatment completely neutralize eye symptoms and improve the quality of life of patients with hemoblastosis.