bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Cystinosis Patients and Factors Associated with Chronic Kidney Disease
Authors: AVCI Begüm , PARMAKSIZ Gönül 
Published: September 2023

Introduction: Cystinosis is a rare genetic, lysosomal storage disorder, leading to kidney involvement and other organs. The most critical factor determining the prognosis is its impact on the kidneys especially nephropatic cystinosis. This study aimed to evaluate cystinosis patients and identify factors associated with chronic kidney disease (CKD).
Methods: The medical records of 18 nephropatic cystinosis patients were retrospectively reviewed. Demographic and clinical features, prognosis were evaluated. Patients were classified according to their estimated glomerular filtration rate (eGFR) at last visit as eGFR60 ml/min/1.73 m2, and were compared for CKD related factors.
Results: The mean age at diagnosis was 46.61±50.42 months. The most common allel was c. 451A>G. Polyuria, polydipsia, vomiting, growth retardation, and renal osteodystrophy were typical presenting symptoms. At diagnosis, the mean eGFR was 72.94±21.69 ml/min/1.73 m². After an average follow-up of 68.28±60.18 months, the mean eGFR was 63.97±23.59 ml/min/1.73 m², and CKD was observed in 44.4% of patients, and 5 (27.8%) underwent kidney replacement theraphy (KRT). In patients with GFR
The Role of Prognostic Factors in Perioperative Adverse Events and Complications in Children with Cleft Palate Repair
Authors: İCİ Elif Eda , LAFLI TUNAY Demet 
Published: September 2023

Aim: Cleft lip and palate (CLP) deformity is the most common type of craniofacial malformation and is usually corrected surgically in infancy. Anesthetic management of children undergoing CLP repair has many challenges. In this study, it was aimed to evaluate the effect of prognostic factors on perioperative complications in children with cleft palate (CP) repair.
Methods: In this study, pediatric cases who underwent cleft palate surgery in a tertiary care hospital between 2015 and 2020 were analyzed retrospectively. The primary outcome measure was perioperative adverse outcomes rate.
Results: The incidence of all perioperative adverse events including airway, and respiratory complications, ICU admission, blood transfusion and re-operation requirement was determined as 40.7% (n=88) and the incidence of respiratory adverse events was found as 28.7% (n=62). Moreover, low body weight (OR 0.69, 95% CI 1.18-1.78, p
Compressive Peripheral Nerve Injuries in Earthquake Victims in Kahramanmaraş Earthquake on February 6, Our Clinical Observations
Authors: AYGÜN BİLECİK Nilüfer , KÖSEHASANOĞULLARI Meryem 
Published: September 2023

Background
Earthquakes are one of the most common causes of mortality and morbidity due to natural disasters. In particular, soft tissue and musculoskeletal injuries are the most common types of injuries following earthquakes and the most common reason for hospital admission. Turkey is a region with a very high risk of earthquakes.
Compression is one of the most common causes of mechanically induced peripheral nerve injuries. Peripheral nerve injuries cause long-term disruptions in daily life, professional development, and education. These injuries are the important causes of labor loss, especially in young adult patients. The purpose of our study is to emphasize the importance of early diagnosis and treatment for these injuries by sharing our observations on compressive peripheral nerve injuries seen in earthquake victims after the Kahramanmaraş earthquakes on February 6.
Materials and Methods
We included patients with peripheral nerve injury who were admitted to the physical therapy clinic of Adana City Hospital for three months starting from February 6, 2023.
Results
The mean age of the injured was 32.64±17.63 years. The median time of being pulled from the rubble was 24 hours. 95.5% were living in Hatay province. The most common sites of peripheral nerve injury were legs (43.3%), arms (17.9%) and forearms (16.4%). 31.3% of the injured had bone fractures. The most common complaints were weakness in the legs (31.3%), foot drops (29.9%), and wrist drops (20.9%).
Conclusion
Earthquake is a natural disaster that can cause blunt and penetrating injuries and serious peripheral nerve injuries. Thus, it should be kept in mind that these injuries, which significantly affect the quality of life, are quite common and may be overlooked during the acute phase after earthquakes.
ANALISIS PENGAMBILAN KEPUTUSAN STRATEGI BISNIS YANG DITERAPKAN NGADEM COFFE
Authors: Fadli Rizal 
Published: September 2023

Research The business feasibility study at this time aims to analyze entrepreneurial
activities in the small and medium business sector in the community, where the source of
this research is a new category where no journals or articles have discussed it. In this study
it also aims to find out what decision-making methods are. what has been implemented
and what strategies were used by the interviewees while running the business so that the
business can survive amidst business competition. This time the author uses a qualitative
method where the author meets directly with the interviewees to interview the business
that has been run by the interviewees so far. It is hoped that data from the interviewees
that has been collected by the author can be analyzed in detail, more detailed, and
structured, and the author is expected to be able to provide input to the results of the
analysis in the field so that in the future the business can develop better and be
competitive in the world. with old and new players who have businesses engaged in the
same field

Penelitian Studi kelayakan bisnis pada kali ini bertujuan untuk menganalisis kegiatan
wirausaha di sektor usaha menengah kecil masyarakat ,dimana sumber penelitian ini
termasuk kategori baru dimana belum ada jurnal atau artikel yang sudah pernah
membahasnya. Didalam penelitian ini juga bertujuan untuk mengetahui metode
pengambilan keputusan seperti apa yang sudah diterapkan dan strategi apa yang
digunakan oleh narasumber selama menjalankan bisnis tersebut sehingga bisnis bisa
bertahan ditengah persaingan bisnis. Kali ini penulis menggunakan metode kualitatif
dimana penulis bertemu secara langsung dengan narasumber untuk mewancarai terkait
bisnis yang sudah dijalankan narasumber selama ini. Diharapkan data dari narasumber
yang sudah dikumpulkan oleh penulis dapat di analisa secara detail, lebih rinci, dan
terstruktur, serta penulis diharapkan dapat memberikan masukkan terhadap hasil
analisa dilapangan agar kedepannya bisnis tersebut semakin bisa berkembang lebih
baik dan bisa bersaing dengan pemain lama maupun baru yang memiliki bisnis yang
bergerak dibidang yang sama.
PENGARUH TINGKAT PENDIDIKAN DAN PELATIHAN KERJA TERHADAP PRESTASI KERJA KARYAWAN UPTD PUSKESMAS GAMPENG KABUPATEN KEDIRI
Authors: Kiki Wulandari  
Published: September 2023

The purpose of this study was to explain the level of influence of education (X1) and professional training (X2) on employee performance (Y). UPTD Gampen Health Center, Kediri Regency. By explaining how much influence it has on employee performance. The survey carried out was a survey with a quantitative approach, the sampling technique used the saturated sample method, from 35 employees used as respondents. The results of the data for this study were obtained through interviews and questionnaires. The technique or method of data analysis used is plausibility test, classic hypothesis test, reliability test, multiple linear analysis, hypothesis testing, and the coefficient of determination. From the results of the field research conducted, it was found that the variable level of education (X1) and job training (X2) greatly influenced the work skills of employees (Y). This work produces a number of linear regression equations in the form of Y = 9.677 + 0.633 X 1 + 0.315 X 2 . The results of the t test for the education level variable were obtained as Sig = 0.002 <0.05. For vocational training, the variable value is Sig = 0.003 <0.05. The results of the F test showed that Sig. = 0.000 <0.05 and the R2 (R-squared) result was 0.305 or (30.5%). From the results of the calculations and analysis carried out, it can be concluded that the level of education (X1) and professional training (X2) has a significant effect on employee performance (Y) UPTD Gampeng Health Center, Kediri Regency.
Tujuan penelitian ini adalah untuk menjelaskan tingkat pengaruh pendidikan (X1) dan training profesional (X2) terhadap kinerja karyawan (Y). UPTD Puskesmas Gampen Kabupaten Kediri. Dengan menjelaskan seberapa besar pengaruhnya terhadap kinerja karyawan. Survei yang dilaksanakan adalah survei dengan pendekatan kuantitatif, teknik pengambilan sampel menggunakan cara metode sampel jenuh, dari sebanyak 35 karyawan digunakan sebagai responden. Hasil data untuk penelitian ini didapatkan melalui wawancara dan kuesioner. Teknik atau cara analisis data yang digunakan adalah uji plausibilitas, uji hipotesis klasik, uji reliabilitas, analisis linier berganda, uji hipotesis, dan koefisien determinasi. Dari hasil penelitian lapangan yang dilakukan diperoleh bahwa variabel tingkat pendidikan (X1) dan training kerja (X2) sangat berpengaruh terhadap keahlian kerja pegawai (Y). Karya ini menghasilkan sejumlah persamaan regresi linier berupa Y = 9,677 + 0,633 X 1 + 0,315 X 2 . Hasil uji t untuk variabel tingkat pendidikan didapatkan seperti nilai Sig = 0,002 < 0,05. Untuk pelatihan kejuruan variabelnya nilai Sig = 0,003 < 0,05. Hasil uji F menunjukkan bahwa Sig.= 0,000 < 0,05 dan hasil R2 (R-squared) sebesar 0,305 atau (30,5%). Dari hasil perhiutngan dan analisis yang dilakukan bisa disimpulkan bahwa tingkat pendidikan (X1) dan training profesi (X2) berpengaruh signifikan terhadap kinerja pegawai (Y) UPTD Puskesmas Gampeng Kabupaten Kediri.
EXPERIMENTAL CHARACTERISATION OF THE WAKE OF A BOTTOM-MOUNTED TWO TANDEM OF CYLINDERS PLACED IN A HIGH VELOCITY AREA
Authors: SANTA CRUZ Alina , Combret Thomas , Hadri Ferhat , Guillou Sylvain 
Published: September 2023

Following the development of renewable marine energies, the characterization of areas with strong marine currents has become necessary. The Normandy coasts (France) are among the sites suitable for the installation of tidal turbine parks because they have significant energy potential. Projects to install machines in these sites raise questions about various factors affecting the performance of the turbines that would be placed there.
We are currently working on the understanding of the mechanisms leading to the generation of ambient flow turbulence on the seabed. More particularly, we are interested in the impact of the complexity of the bathymetry on the organization of the wake generated. To simplify the modeling of the bathymetry of the seabed, we use generic cylindrical obstacles of rectangular section. The obstacles are placed on the bottom of the study area of ​​the Hydrodynamic Tunnel of the LUSAC laboratory and occupy its entire width. Measurements are made using Particle Image Velocimetry (PIV-2D) for a velocity flow of 3 m/s.
In a first time, in a previous contribution, was evaluated the impact of the ratio between the Height and the Width (H/W) of the cross section of the cylinder on the organization of the near wake. Indeed, the average velocity fields obtained for six different obstacles, highlighted the modification of the organization of the flow topology. The variation of this ratio H/W leads to the modification of the length of the average vortex formation zone, implies the presence of two or even three average recirculation zones in the near wake of the cylinder and leads to the possible presence of a recirculation zone average placed upstream of the cylinder.
Nevertheless, in the seabed the structures are not isolated. In the contrary, on the seabed we can observe successions of structures anchored on the funds, leading to the interaction of a structure with the wake generated upstream by another one structure. The experimental study with the characterization of the flow around a tandem of “long” cylindrical obstacles of square section (side H). The distance between these two cylinders is equal to 2H.
As expected, in the present study, it can be observed the modifications of the topology of the mean flow and the distribution of the turbulent kinetic energy. Indeed, the interaction between the mean recirculation, generated downstream each cylinder, is shown.
Studi Bioinformatika Kandungan Curzerene Pada Daun Dewandaru (Eugenia uniflora Linn.) Sebagai Antikanker Prostate Melalui Pensinyalan PI3K
Authors: Andriese Ni Putu Sri Ayu Sevilla Andriese , Santoso Puguh , Ari Candra Agung , Surya Rahadi I Wayan 
Published: September 2023

Salah satu tanaman asli Indonesia yang berkhasiat sebagai obat adalah dewandaru (Eugenia uniflora Linn.). Dewandaru menunjukkan aktifitas sitotoksik terhadap sel kanker sehingga berpotensi untuk dijadikan sediaan obat. Senyawa potensial dari daun dewandaru yaitu Curzerene . Penelitian ini dilakukan untuk mengidentifikasi interaksi antara senyawa daun dewandaru dengan reseptor PI3K pada kanker prostat. Studi ini menggunakan metode komputasi yang dikenal sebagai molecular docking. Energi ikatan, visualisasi ikatan, serta jenis ikatan antara senyawa dan reseptor diamati. Reseptor PI3K telah memenuhi syarat uji validasi metode. Hasil penelitian menunjukan senyawa pada tanaman dewandaru dapat menghambat satu protein target dari kanker prostat yang dinyatakan dengan nilai ∆Gbinding terendah yaitu senyawa Curzerene (-7,65 kkal/mol) pada protein PI3K. Interaksi antara senyawa Curzerene memiliki nilai binding energy lebih rendah jika dibandingkan ligan asli pada reseptor PI3K. Sehingga, dapat disimpulkan bahwa senyawa Curzerene pada tanaman dewandaru yang digunakan dalam penelitian memiliki interaksi yang baik dengan reseptor PI3K pada kanker prostat. Senyawa ini berpotensi untuk dikembangkan sebagai obat antikanker. Perlu dilakukan pengujian in vivo serta modifikasi pada struktur senyawa sehingga dapat digunakan sebagai terapi antikanker pada kanker prostat secara efektif.
Kata Kunci: Kanker prostat, Curzerene, Daun dewandaru, In silico
Efek Ekstrak Etanol Buah Dewandaru (Eugenia uniflora L) terhadap Penurunan Kadar Glukosa Darah dan Perbaikan Sel Beta Pankreas pada Mencit yang Diinduksi Aloksan
Authors: Maharani Ade Dwi Karisma , Santoso Puguh , Udayani Ni Nyoman Wahyu 
Published: September 2023

Diabetes mellitus adalah suatu penyakit metabolik dengan karakteristik hiperglikemia akibat gangguan sekresi insulin. Buah Dewandaru (Eugenia uniflora L.) memiliki kandungan flavonoid yang berperan sebagai penangkal radikal bebas dan mengurangi stress oksidatif. Penelitian ini bertujuan untuk membuktikan pemberian ekstrak etanol buah dewandaru dosis 200mg/KgBB dan 400mg/KgB dapat menurunkan kadar glukosa darah dan memperbaiki kerusakan sel β pankreas pada mencit putih (Rattus norvegicus) jantan galur wistar diabetes mellitus yang diinduksi aloksan. Penelitian ini menggunakan 32 ekor mencit yang berumur 2-3 bulan dengan berat 25 gram yang diinduksi aloksan (0,5 ml/kgBB) secara intraperitoneal. Mencit dibagi menjadi empat kelompok perlakuan, yaitu K- (aloksan), K+ (glibenklamid), P1 (dosis ekstrak buah dewandaru 200 mg/kgBB), P2 (dosis ekstrak buah dewandaru 400 mg/kgBB). Data kuantitatif dengan menghitung kadar glukosa darah dan jumlah sel β pankreas dianalisis dengan uji paired t-test. Setelah diuji dengan melihat penurunan kadar glukosa darah dan histopatologi sel β pankreas, pada kelompok eksperimental yaitu P1 dan P2 penurunan kadar glukosa yang baik terdapat pada kelompok P2 yaitu dosis ekstrak buah dewandaru 400 mg/kgBB. Pada perbaikan sel β pankreas dinyatakan bahwa rata-rata kerusakan sel β pankreas pada dosis 200mg/KgBB yaitu 67,5 dan dosis 400mg/KgBB yaitu 89,1. Penelitian ini membuktikan bahwa ekstrak etanol buah dewandaru mampu menurunkan glukosa darah serta menghambat laju kerusakan sel β jaringan pankreas pada mencit yang menderita diabetes mellitus.
Kata kunci : dewandaru, diabetes mellitus, glukosa darah, sel β pankreas
PENGARUH UKURAN PERUSAHAAN DAN PROFITABILITAS TERHADAP NILAI PERUSAHAAN MELALUI KINERJA KEUANGAN PADA PERUSAHAAN PROPERTY DAN REAL ESTATE YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2019-2021
Authors: Kamiliya Kamiliya , Wiryaningtyas Dwi Perwitasari , Pramitasari Triska Dewi 
Published: September 2023

A company is an organization with a legal entity that has an important role in the economic development of a country. The aim of this study is to determine the effect of company size and profitability on company value through the financial performance of property and real estate companies that are listed on the Indonesia Stock Exchange in 2019-2021. This current study employed a purposive technique sampling. The data analysis and hypothesis testing in this study used Structural-Partial Least Square Equation Model (PLS-SEM).
The results of the direct influence hypothesis test using the Smart application PLS 3.0 shows that company size has no significant effect on financial performance, profitability has a significant effect on financial performance, company size has no effect significant to firm value, profitability has no effect significant to firm values, financial performance has no effect significant to firm value. The results of the indirect hypothesis test show that firm size through financial performance has a negative but not significant effect on the firm values and profitability through performance financial effect positive but not significant to firm value.
PENGARUH PROFESIONALISME, PENGALAMAN KERJA, DAN PENDIDIKAN AUDITOR EKSTERNAL TERHADAP KUALITAS AUDIT
Authors: Ferdyansah Nico , Yulinartati Yulinartati , Nuha Gardina Aulin 
Published: September 2023

Penelitian ini bertujuan untuk menguji pengaruh Profesionalisme, Pengalaman Kerja, dan Pendidikan Auditor Eksternal terhadap Kualitas Audit pada Kantor Akuntan Publik di Kota Malang. Penelitian ini menggunakan jenis penelitian deskriptif pendekatan kuantitatif yang diukur dengan menggunakan SPSS versi 25. Populasi penelitian ini adalah Kantor Akuntan Publik di wilayah Kota Malang. Sampel ditentukan menggunakan purposive sampling, dengan jumlah sampel sebanyak 10 Kantor Akuntan Publik (KAP) yang berada di Kota Malang, sehingga total responden dalam penelitian ini sebanyak 73 responden. Pengujian hipotesis dengan menggunakan uji parsial (uji t), regresi linier bergana, uji koefiensi determinasi dan uji simultan (uji f). Hasil pengujian membuktikan bahwa hasil analisis data dengan menggunakan uji parsial (uji t) yaitu (1) Profesionalisme berpengaruh secara signifikan terhadap Kualitas Audit. (2) Pengalaman Kerja berpengaruh secara signifikan terhadap Kualitas Audit. (3) Pendidikan Auditor Eksternal tidak berpengaruh secara signifikan terhadap Kualitas Audit. (4) Hasil analisis data dengan menggunakan uji simultan (uji f) yaitu Profesionalisme, Pengalaman Kerja, dan Pendidikan Auditor Eksternal berpengaruh signifikan secara bersama-sama terhadap Kualitas Audit.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI HARGA SAHAM PADA PERUSAHAAN MANUFAKTUR SUBSEKTOR MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2018-2021 DENGAN KEBIJAKAN DIVIDEN SEBAGAI VARIABEL INTERVENING
Authors: Fitrianingsih Desiana , Hamdun Edy Kusnadi , Wiryaningtyas Dwi Perwitasari 
Published: September 2023

Investors assess the performance of a company through its Stock price. The number of requests and offers for shares that occur in the capital market affects the high and low prices of company shares. If the company's performance is in good condition, then the company's shares will be in demand by investors so that the share price will be high. The purpose of this study was to analyze and examine the factors that influenced stock prices in food and beverage sub-sector manufacturing companies listed on the Indonesia Stock Exchange with Dividend policy as an intervening variable. The sampling technique in this study was determined by purposive sampling. Data analysis and hypothesis testing in this study used the Structural-Partial Least Square Equation Model (PLS-SEM).
The results of the direct influence hypothesis test show the following results. Debt to Equity Ratio has a positive but not significant effect on Dividend policy. Net Profit Margin has a negative but not significant effect on Dividend policy. Debt to Equity Ratio has a negative but not significant effect on Stock prices. Net Profit Margin has a significant negative effect on Stock prices. Dividend policy has a significant positive effect on Stock prices. The results of the indirect effect hypothesis test show that the Debt to Equity Ratio variable has a positive but not significant effect on Stock prices through Dividend policy. Net Profit Margin has a negative but not significant effect on Stock prices through Dividend policy.
DAMPAK LINGKUNGAN KERJA DAN DISIPLIN KERJA TERHADAP KINERJA PNS DENGAN KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING PADA KANTOR BAPENDA KABUPATEN BANYUWANGI
Authors: Yulianingtiyas Liana , Ediyanto Ediyanto , Minullah Minullah 
Published: September 2023

Humans Regional Revenue Office of Banyuwangi is an organization of government apparatus with a good reputation as implementing element in government, community and development sectors led by the head of department who is responsible to Regent through Regional Secretary. The purpose of this study is to analyze the effect of work environment and work discipline on performance with Job Satisfaction as an intervening variable at Regional Revenue Office of Banyuwangi by using Partial Least Square – Structural Equation Modeling (PLS-SEM).
The results of direct effect hypothesis testing using Smart PLS 3.0 application show that work environment has a significant positive effect on job satisfaction (H1 is accepted), work discipline has a significant positive effect on job satisfaction (H2 is accepted), work environment has a significant positive effect on performance (H3 is accepted), work discipline has a negative and not significant effect on performance (H4 is rejected), job satisfaction has a significant positive effect on performance (H5 is accepted), work environment has a significant positive effect on performance through job satisfaction (H6 is accepted), work discipline has a positive but not significant effect on performance through satisfaction Work (H7 is rejected).
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEPUTUSAN PEMBELIAN PADA PERMATA BAKERY DI SITUBINDO DENGAN MINAT BELI SEBAGAI VARIABEL INTERVENING
Authors: Yolanda Mariska Anis , Arief Mohammad Yahya , Fandiyanto Randika 
Published: September 2023

In business world, there are various ways to achieve success. Every businessman always learns how to make the business reach its target. The desired profit will encourage business people to achieve the determined targets. A businessman will keep on looking for opportunities for their company's marketing. Competition will keep happening, so opportunities must be seen and targets must be achieved. Therefore, Permata Bakery shop must be able to choose the right marketing strategy to develop and maintain the business stability because that becomes an indicator to get success. The purpose of this study is to analyze the factors that influence purchasing decisions at Permata Bakery in Situbondo with purchase intention as an intervening variable. The population in this research is the consumers of Permata Bakery shop. The sampling technique is determined by probability sampling. Data analysis and hypothesis testing use Partial Least Square - Structural Equation Modeling (PLS-SEM).
The results of the direct effect hypothesis testing using Smart PLS 3.0 application show that product quality has a significant effect on purchase intention, product quality has a significant effect on purchase decisions, word of mouth has a significant effect on purchase intention, word of mouth has a significant effect on purchase decisions, and purchase intention has an effect significant to the purchase decision. The results of the indirect effect hypothesis testing reveal that product quality variable has a significant positive effect on purchasing decisions through purchase intention. Word of mouth has a significant positive effect on purchasing decisions through purchase intention