bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentially fatal atrium perforation due to right jugular vein catheterization recognized by venography: A case report
Authors: Jahanshahi Fatemeh , Parsaei Amirhossein , Naderi Delaram , Zeraatian Nejad Davani Sam , Khaleghian Mohsen 
Published: February 2023

AbstractCentral venous catheters are the prevalent path for dialysis. Our case was a 54‐years‐old male with a new case of end‐stage renal disease with a complaint of right jugular hemodialysis catheter dysfunction. In our case, the early dysfunctional catheter should be evaluated with contrast studies to achieve accurate information.
Post‐COVID‐19 vaccine acute encephalitis in an adult patient: A case report and literature review
Authors: Pakfetrat Maryam , Malekmakan Leila , Najafi Bijan , Zamani Taraneh , Mashayekh Mina 
Published: February 2023

AbstractSeveral vaccines were approved after COVID‐19 pandemic, which have been fast‐tracked for emergency use. The short‐ and long‐term safety profile has been an area of concern. We presented a patient with encephalitis followed by hyponatremia who developed hallucination and seizure 1 day after receiving the second dose of Sinopharm vaccine.
A case of chronic ossified hematoma presented as a skull lesion: A literature review on two rare conditions, cephalhematoma, and intradiploic hematoma
Authors: Iranmehr Arad , Sarpoolaki Mohammad Kazem , Zeinalizadeh Mehdi 
Published: February 2023

AbstractCephalhematoma is a frequent condition in newborn infants due to birth‐related trauma, but ossified cephalhematoma (OCH) is a rare condition, especially when it presents as a skull lesion in the older pediatric population. Chronic intradiploic hematoma (CIH) is another rare condition caused by an organized hematoma between the inner and outer tables of the skull. Differentiating CIH from OCH could be difficult for young neurosurgeons. We present an 18‐month‐old girl with an OCH presented as a skull lesion, which was managed with craniectomy and en‐bloc excision of the organized hematoma. This manuscript discusses the differences between OCH and CIH in diagnosis and management.
Clinical manifestations of Apert syndrome
Authors: Khan Qaisar Ali , Farkouh Christopher , Uzair Muhammad , Ghosh Bikona 
Published: February 2023

AbstractApert syndrome presents similarly to the one we presented in this image, and a genetic study is used for confirmation. This image shows the typical findings of physical examination, so that if this appears in the outpatient department, the diagnosis of Apert syndrome should be assumed.
Metastatic sigmoid adenocarcinoma to the larynx: A case report and updated literature review
Authors: Aljariri Adham A. , Nashwan Abdulqadir J. , Hammoud Rani , Wazwaz Bara , Al Hyassat Samir , Haidar Hassan 
Published: February 2023

AbstractMetastatic laryngeal cancer is a rare entity, usually indicating an advanced disease once discovered. In this report, we are describing a case of a 60‐year‐old male patient with stage IV colorectal cancer (CRC), who presented to our clinic with dysphonia; further workups showed metastatic CRC.
Polypyridine Iridium(III) and Ruthenium(II) Complexes for Homogeneous and Graphene‐Supported Photoredox Catalysis
Authors: Jacques Alexandre , Devaux Alexandre , Rubay Christophe , Pennetreau Florence , Desmecht Antonin , Robeyns Koen , Hermans Sophie , Elias Benjamin 
Published: February 2023

AbstractIridium(III) and ruthenium(II) polypyridyl based photocatalysts have been prepared and their structure determined using 1H NMR, HR‐MS and single crystal XRD. Their spectroscopic and electrochemical properties have been studied by UV‐vis absorption, emission spectroscopy and cyclic voltammetry. These complexes have been used as photoredox homogeneous catalysts in an intramolecular cyclization model reaction in which they show high activity. They have been covalently anchored on graphene oxide (GO) via an esterification reaction and non‐covalently fixed on reduced graphene oxide (rGO) via pyrene moieties. Heterogenized complexes exhibit good photocatalytic activities and, interestingly, the use of a pyrene‐derivatized Ir(III) terpyridine‐based complex highlights an unexpected “on/off” effect of the photocatalytic activity triggered by the presence or absence of rGO.
Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol‐Sensitive Release Platform
Authors: Studer Tetiana , Morina Daria , Shchelik Inga S. , Gademann Karl 
Published: February 2023

AbstractThis study reports on the design and engineering of biohybrid microswimmers exploiting a thiol‐mediated self‐immolative antibiotic release strategy. The design features a covalent attachment of a vancomycin conjugate via a disulfide‐based linker to the surface of the microalgae Chlamydomonas reinhardtii. The antibiotic release from the surface of these biohybrids was triggered by the addition of a thiol‐based reducing agent, and, subsequently, the inhibition of bacterial growth was observed for Bacillus subtilis and Staphylococcus aureus. These engineered microbots represent the first example of a microalgae‐based drug delivery system with a thiol‐mediated, reductive release of an antibiotic drug.
Computational Evidence of the Incipient Oxocarbenium Ion as a “Hidden Intermediate” During the Cyclization of Hydroxyenol Ether into Spiroketal Under Mild Acidic Condition
Authors: Jindani Sana , Ganguly Bishwajit 
Published: February 2023

AbstractThe synthesis of spiroketals has gained attention because of their importance in chemical and biological reactions. Yet, the mechanistic investigation of mild acid‐catalyzed spiroketalization remains elusive and less explored in the literature and speculated that such transformations may proceed through the oxocarbenium ion intermediate; however, the existence of such species in mild acid‐catalyzed spiroketalization is not documented. The computational study has been performed at M06‐2X/6‐31+G(d) level to examine the kinetically controlled product formation for such reactions and the intrinsic reaction coordinates of 1 d suggest that the reaction proceeds via a “one‐step, two‐stage” mechanism with the formation of transient oxocarbenium as a “hidden intermediate” in the reaction. This study reveals that stereoelectronic interactions devoid the formation of stable oxocarbenium ion intermediate after the proton transfer transition state in the mild acid catalyzed spiroketalization process.
Anticancer Activities of Tetrasubstituted Imidazole‐Pyrimidine‐Sulfonamide Hybrids as Inhibitors of EGFR Mutants
Authors: Alghamdi Eman M. , Alamshany Zahra M. , El Hamd Mohamed A. , Taher Ehab S. , Farrag El‐Behairy Mohammed , Norcott Philip L. , Marzouk Adel A. 
Published: February 2023

AbstractA new series of tetrasubstituted imidazole derivatives carrying pyrimidine sulfonamide pharmacophores has been synthesized and evaluated for their anticancer activities. In‐vitro screening of these hybrids against a full 60‐cell‐line panel at a single dose of 10 μM showed significant growth inhibition of up to 95 %. The most active compound showed in‐vitro anticancer activities against (i) abnormal HER2 and (ii) two mutants for EGFR. Apoptotic gene expression revealed that lead compounds induced MCF‐7 cell line apoptosis together with considerable change in the Bax/Bcl‐2 expression ratio. One lead compound led to a significant cell‐cycle S‐phase arrest, while another blocked the cell cycle at G1/S‐phase causing the accumulation of cells. Docking analysis of these two hybrids adopted the orientation and binding interactions with a higher liability to enter the active side pocket of HER2, L858R, and T790 M, preferable to that of co‐crystallized ligands. Modelling simulation was consistent with the acquired biological evaluation.
Estrous cycle impacts on dendritic spine plasticity in rat nucleus accumbens core and shell and caudate–putamen
Authors: Beeson Anna L. S. , Meitzen John 
Published: February 2023

AbstractAn important factor that can modulate neuron properties is sex‐specific hormone fluctuations, including the human menstrual cycle and rat estrous cycle in adult females. Considering the striatal brain regions, the nucleus accumbens (NAc) core, NAc shell, and caudate–putamen (CPu), the estrous cycle has previously been shown to impact relevant behaviors and disorders, neuromodulator action, and medium spiny neuron (MSN) electrophysiology. Whether the estrous cycle impacts MSN dendritic spine attributes has not yet been examined, even though MSN spines and glutamatergic synapse properties are sensitive to exogenously applied estradiol. Thus, we hypothesized that MSN dendritic spine attributes would differ by estrous cycle phase. To test this hypothesis, brains from adult male rats and female rats in diestrus, proestrus AM, proestrus PM, and estrus were processed for Rapid Golgi–Cox staining. MSN dendritic spine density, size, and type were analyzed in the NAc core, NAc shell, and CPu. Overall spine size differed across estrous cycle phases in female NAc core and NAc shell, and spine length differed across estrous cycle phase in NAc shell and CPu. Consistent with previous work, dendritic spine density was increased in the NAc core compared to the NAc shell and CPu, independent of sex and estrous cycle. Spine attributes in all striatal regions did not differ by sex when estrous cycle was disregarded. These results indicate, for the first time, that estrous cycle phase impacts dendritic spine plasticity in striatal regions, providing a neuroanatomical avenue by which sex‐specific hormone fluctuations can impact striatal function and disorders.
Inflammatory myofibroblastic tumor of the mesentery with a SQSTM1::ALK fusion responding to alectinib
Authors: Sunga Cass G. G. , Higgins Michael S. , Ricciotti Robert W. , Liu Yajuan J. , Cranmer Lee D. 
Published: February 2023

AbstractBackgroundInflammatory myofibroblastic tumor (IMT) is an ultra‐rare soft tissue neoplasm associated with fusion proteins encompassing the anaplastic lymphoma kinase (ALK) protein fused to a variety of partner proteins. Data regarding response to ALK‐targeting agents based on fusion partner is limited.CaseA 30‐year‐old female sought emergency care after onset of abdominal and lower back pain in 2019. Computed tomography (CT) demonstrated a cystic, mesenteric mass within the pelvis measuring up to 8.9 cm. Complete laparoscopic excision of the mass from the mesentery of the right colon and terminal ileum was performed. Pathologic assessment revealed IMT with a fusion between sequestosome 1 and ALK (SQSTM1::ALK), described in only two other cases of IMT. Four months after surgery, CT revealed multi‐focal, unresectable disease recurrence. She was referred to the University of Washington/Fred Hutchinson Cancer Center and placed on therapy with alectinib, after which she experienced a partial response. Three years after IMT recurrence, disease remains under control.ConclusionThis is the third reported case of IMT associated with the novel SQSTM1::ALK fusion protein, and the second treated with alectinib. Treatment with the ALK inhibitor alectinib appears to be active in this setting.
Luminescent Lanthanide Complexes for Effective Oxygen‐Sensing and Singlet Oxygen Generation
Authors: Kitagawa Yuichi , Nakai Takuma , Hosoya Shota , Shoji Sunao , Hasegawa Yasuchika 
Published: February 2023

AbstractOxygen quantification using luminescence has attracted considerable attention in various fields, including environmental monitoring and clinical analysis. Among the reported luminophores, trivalent lanthanide complexes have displayed characteristic narrow emission bands with high brightness. This bright emission is based on photo‐sensitized energy transfer via organic triplet states. The organic triplet states in lanthanide complexes effectively react with the triplet oxygen, enabling oxygen quantification by lanthanide luminescence. Some TbIII and EuIII complexes with slow deactivation processes have also formed the excited state equilibrium, thus resulting in the emission‐lifetime based oxygen sensing property. The combination of TbIII/EuIII emission, EuIII/SmIII emission, EuIII/ligand phosphorescence, and ligand fluorescence/ligand phosphorescence provide the ratiometric oxygen‐sensing properties. Moreover, the reaction generates singlet oxygen species which exhibit numerous applications in the photo‐medical field. The ligands with large π‐conjugated aromatic systems, such as porphyrin, phthalocyanine, and polyaromatic compounds, induces highly efficient oxygen generation. The combination of effective luminescence with singlet‐oxygen generation by the lanthanide complexes render them suitable for photo‐driven theranostics. This review summarizes the research progress of lanthanide complexes with efficient oxygen‐sensing and singlet‐oxygen generation properties.
Simulation of the statistical and formative time delay of Townsend‐mechanism‐governed breakdown in argon at low pressure
Authors: Jovanović Aleksandar P. , Stankov Marjan N. , Marković Vidosav Lj. , Stamenković Suzana N. 
Published: February 2023

AbstractUnderstanding the breakdown process is important both from fundamental and practical perspectives. One of the most important quantities that characterize the breakdown is the breakdown time delay. In this article, numerical models for self‐consistent simulation of the statistical and formative time delay of the electric breakdown in argon at low pressure have been proposed. The first model, based on the Monte Carlo simulation of the electron avalanche development, is used to simulate the statistical time delay. The model is designed for low‐pressure breakdowns when the Townsend mechanism is dominant. The electric breakdown is then governed by ion‐induced secondary electron emission from the cathode. In that case, the statistical time delay to breakdown is determined by tracking the waiting time of emission of the primary electron that initiates the electron avalanche and the number of ions produced in it. On the other hand, the formative time delay is determined by simulating the electric current waveform using the fluid model. To test whether the proposed models can be used for discharges operating under various conditions, the voltage dependence is simulated for both the statistical and the formative time delay. The results of the simulations show good agreement with the experimental results and theoretical models.
Bionic surface diode for droplet steering
Authors: Yang Xiaolong , Qi Biao , Lu Yao , Zhang Wang , Wang Xiaolei 
Published: February 2023

AbstractControl of droplet sliding and its interfacial behavior such as sliding resistance and friction have important applications in microfluidic and energy‐related fields. Nature provides many examples of interface‐driven droplet sliding control; yet, to date, the continuous governing of the multiphase process and precise steering of droplet sliding remain challenging. Here, directional‐dependent ultraslippery patterned surfaces with significant droplet sliding anisotropy were created by coordinating the heterogeneous wettability of the back of the dessert beetle, directional‐dependent architecture of the butterfly wing, and ultraslippery configuration of the Nepenthes alata. Analysis of the sliding resistance on typical ultraslippery patterned surfaces reveals that the directional‐dependent triple phase line (TPL) immigration on the ultraslippery patterns dominates the strong sliding anisotropy, which can be modeled using the classic Furmidge equation. In particular, the sliding anisotropy for the semicircular ultraslippery patterned surface shows threefold higher than that of natural butterfly wings due to the most significant difference in TPL immigration in two opposite directions, which enables the simultaneous handling of multiple droplets without mass loss and steering of droplet sliding/friction. This work may transform the design space for the control of multiphase interface motion and the development of new lab‐on‐a‐chip and droplet‐based microsystems.
DRD4 allele frequencies in greylag geese vary between urban and rural sites
Authors: Mai Sabrina , Wittor Caroline , Merker Stefan , Woog Friederike 
Published: February 2023

AbstractWith the increasing urbanization of the last decades, more and more bird species occur in urban habitats. Birds which thrive in urban habitats often have a higher tolerance toward human disturbance and show behaviors which differ from their rural counterparts. There is increasing evidence that many behaviors have a genetic basis. One candidate gene is the dopamine receptor D4 (DRD4), which has been associated with fear and thus, flight initiation distance (FID). In this study, we analyzed a segment of DRD4 in greylag geese Anser anser, describing the variability of this gene across several geographically distant populations, and comparing its variability between an urban and a rural site in south–west Germany. We additionally measured FIDs of urban and rural geese to test for a possible correlation with DRD4 genotypes. We found a high variation within DRD4, with 10 variable sites leading to 11 alleles and 35 genotypes. Two genotypes occurred in 60% of all geese and were thus defined as common genotypes versus 33 rare genotypes. Population differentiation was very low between the urban and rural sites in Germany but common genotypes occurred more often in the urban area and rare genotypes more often in the rural area. FID was significantly higher at the rural site, but no significant correlation between FID and DRD4 genotypes could be detected. Nevertheless, our results suggest that local site selection may be related to DRD4 genotypes.
Does weather drive habitat use and movement of a nonmigratory bird?
Authors: Neumann L. K. , Davis C. A. , Fuhlendorf S. D. , Elmore R. D. 
Published: February 2023

AbstractClimate change is predicted to increase the intensity and frequency of weather extremes (e.g., extreme heat and drought), which will likely affect wildlife species in significant ways. Maintaining landscape heterogeneity has been suggested as a potential conservation strategy to buffer animals from weather extremes. Because animal movement influences survival and population connectivity, understanding animal space use and movement in response to shifts in weather is useful for the conservation of wildlife. Nonmigratory species are predicted to be more negatively affected by climate change because they have a limited ability to disperse to find resources. We studied the Northern Bobwhite (Colinus virginianus; hereafter, bobwhite) to understand how weather alters habitat use and movement of a nonmigratory animal across a landscape. We collected telemetry locations on bobwhite across western Oklahoma during 2019–2020 and paired these data with meteorological and vegetation data. We analyzed the data at two temporal scales—hourly locations and 12‐h paths. At the hourly scale, we analyzed tree cover use, shrub cover use, and normalized difference vegetation index (NDVI) use using generalized or linear‐mixed models. At the 12‐h scale, we calculated three different movement metrics: cumulative distance, net displacement, sinuosity and analyzed each movement metric separately using generalized linear‐mixed models. We found that bobwhite used denser tree cover and higher NDVI values as air temperature increased in conjunction with solar radiation. Bobwhite used denser shrub cover as air temperature increased and average wind speed was high as well as when air temperature and average wind speed were low. The interaction between variability in vegetation and climate influenced bobwhite movement. Bobwhite in areas with higher NDVI variance moved farther when mean air temperatures were >0°C than bobwhite in areas with low NDVI variance. When mean air temperatures were ≤0°C, NDVI variance had little effect on the cumulative distance moved of bobwhite. Our findings show that some animals use different vegetation types during different weather conditions and that variability in vegetation on the landscape and weather together alters animal movement. Managing for landscape heterogeneity is a solution that may buffer animals from increased climate variability in the future.
Greening recovery – Overcoming policy incoherence for sustainability transformations
Authors: Gottenhuber Sara , Linnér Björn‐Ola , Wibeck Victoria , Persson Åsa 
Published: February 2023

AbstractPolicy coherence is crucial in the 2030 Agenda's transformative ambitions and heralded as of paramount importance to ensure the successful implementation of the 17 Sustainable Development Goals and climate policy targets. Despite political efforts to achieve policy coherence, apparent trade‐offs and goal conflicts have emerged – even in a proclaimed ‘front‐runner’ country like Sweden. This paper examines the role of ideas in proposing and legitimising policy options and achieving policy coherence in the light of the Swedish recovery debate in 2020 following the COVID‐19 pandemic. Ideas of a green economic recovery put forward in the public debate are examined through thematic text and frame analysis. We show that ideas of a green transition, boosted by economic recovery spending, draw on a synergistic frame in combining social, environmental, and economic policy options, carrying a potential for coherency. However, the absence of a discussion on power, as in who stands to gain what under which circumstances, coupled with an inherent understanding of a temporal hierarchy of policy priorities does not only impact the ability to design coherent policies but may have considerable impacts on the prospects of achieving sustainability transformations.
Dual‐signal immuno‐competitive determination of brain natriuretic peptide based on magnetic nanozyme
Authors: Xu Xiao‐Hui , Xia Junjie , Song Sunfengda , Liu Yawen , Chen Jie , Zhong Suyun , Chen Hongxia , Zhang Zhao‐Huan 
Published: February 2023

AbstractBrain natriuretic peptide (BNP) has been a disease marker in the diagnosis of heart failure. In this study, gold nanoparticles modified with Hemin (H‐AuNPs) as nanozymes were used to oxidize ABST and MB to amplified colorimetric and electrochemical redox signals respectively. BNP was combined with H‐AuNPs (BNP‐H‐AuNPs) through electrostatic adsorption to construct competitive nanozyme probes. Target BNP in the sample compete with BNP‐H‐AuNPs to bind the antibody‐modified magnetic nanoparticles (AntiBNP‐MNPs). Due to the excellent catalytic performance of the nanozyme, BNP can be observed well by colorimetric and electrochemical assays. Electrochemical method ensured more accurate detection of BNP with a wide detection range (1–200 pg/mL) and a low detection of limit (0.03 pg/mL). Meanwhile, the results of the experiment can be easily observed with the naked eye by simple colorimetric method with a range from 5 ng/mL to 25 ng/mL and a limit of detection down to 80.3 pg/mL. Thus, based on the important role of H‐AuNPs, this assay has exhibited potential value of detection the other small proteins through this competitive nanozyme method.
Predicting customer churn using grey wolf optimization‐based support vector machine with principal component analysis
Authors: Durkaya Kurtcan Betul , Ozcan Tuncay 
Published: February 2023

AbstractCustomer churn is a challenging problem that can lead to a loss of organizational assets. Organizations need to predict customer churn successfully in order to get rid of potential damages and gain a competitive advantage. The aim of this study is to provide a churn prediction model by including feature selection and optimization in classification. The study performs principal component analysis (PCA) to select the best features, support vector machine (SVM) to predict customer churn, and grey wolf optimization (GWO) to optimize the parameters of SVM. In other words, this study proposes a novel hybrid model called PCA‐GWO‐SVM to enhance the prediction ability in customer churn. A comparison experiment is carried out, evaluating the proposed model with the other classification algorithms. Experimental results show that the proposed PCA‐GWO‐SVM hybrid model produces higher accuracy, recall, and F1‐score than other machine learning algorithms such as logit, k‐nearest neighbors, naive Bayes, decision tree, and SVM.