bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Electrochemical Development of Highly Charged TiO 2 -NPs Nanoparticles Decorated With Reduced Graphene Oxide For The Detection of Trace Chloroquine In Contaminated Human Urine And Serum Samples
Authors: Zoubir Jallal , Bakas Idriss , assabbane Ali 
Published: March 2023

Abstract
An important step in the development of electrochemical sensors is the modification of the working electrode surface. In this study, a simple synthesis of TiO2 nanoparticles on reduced graphene oxide sheets was used as the basis for the development of an electrochemical sensor for the voltammetric measurement of chloroquine. This method allowed the fabrication of completely new, so-called modified electrodes with very high electrocatalytic activity and distinct chemical reactivity. Using a variety of techniques, the nanocomposites were characterized morphologically. XRD, IR, SEM, HRTEM, and BET revealed modifications of the functional groups and the attachment of titania to the reduced graphene oxide portion on the electrode surface, which can be used to explain the enhanced electrochemical performance of the TiO2-NPs @RGO /GCE. High electrocatalytic activity towards chloroquine molecules. The proposed TiO2 -NPs @RGO/GCE sensor demonstrated a wide linear dynamic range for chloroquine analysis from 10− 4 M to 10− 7 M with a detection limit LOD = 1x10− 8 M. The applicability of this device for the analysis of water, pharmaceutical, human urine and serum samples was demonstrated. For the samples examined, a recovery between 97% and 102% was achieved with acceptable recovery.
Green Synthesized Silver Nanoparticles Using Argyreia Nervosa Leaf Extract and Their Antimicrobial Activity
Authors: K Parvathalu , S Chinmayee , B Preethi , A Swetha , G Maruthi , M Pritam , B Sreenivas , S Ramu Naidu , Merlin Sheeba , B Murali , M Vijay , K Moses , D Chinni Krishna , P Bala Bhaskar 
Published: March 2023

Abstract
The biogenic synthesis of silver nanoparticles (AgNPs) has attracted many researchers due to their physical, chemical, optical, and biological properties, embracing range of activities such as antibacterial, antifungal, anti-inflammatory, and anti-cancer activities. The purpose of this work is to synthesize and characterize AgNPs using Argyreia Nervosa (AN) plant leaf extract as well as to test their antimicrobial applications. In this work, silver nitrate (AgNO3) at 0.1mM concentration, and stable AgNPs were synthesized and observed by monitoring the colour change of the solution from light yellow to brown. The UV-Vis spectrum shows a peak at 445nm, confirming the formation of AN-AgNPs and Fourier-transformed infrared (FTIR) results confirm the presence of chemical groups which act as reducing agents stabilizing the AN-AgNPs and antimicrobial capping agents enhancing antimicrobial properties of AN-AgNPs. The crystalline behaviour of these AN-AgNPs confirms through X-Ray Diffraction (XRD) peaks. The morphology of AN-AgNPs and their size shows different sizes, ranging from 10 to 40nm using Scanning Electron Microscopy (SEM). The disk diffusion assay shows the antimicrobial activity over E-Coli pathogenic microorganisms of clinical interest. The obtained results confirm a more significant antimicrobial effect of the biogenic AN-AgNPs maintaining low cytotoxicity. This work presents a potential way to produce non-toxic biogenic AgNPs with enhanced antibacterial activity, which can meet the increasing global demand for biogenic AgNPs as an alternative to antibiotics.
Evaluation of diode laser-assisted treatment for benign eyelid margin lesions
Authors: Jeon Gang Seok , Hong In Hwan , Lee Tae Yeem , Song Tae Geun , Han Jae Ryong 
Published: March 2023

Abstract
PURPOSE: To report the treatment response of benign eyelid margin tumors with a laser ablation as an alternative to shaving biopsy
METHODS: Fifty-eight patients with 61 benign tumors of the eyelid margin were included in this study retrospectively (2019_2022). In all patients, the tumor was eliminated by laser ablation or shaving biopsy. Twenty-nine cases were eliminated by laser ablation and 28 cases were removed by shaving excision biopsy. Comparative analysis was done between the laser-assisted ablation patients group: Group 1 and shaving excision surgery patients group: Group 2. Postoperatively, histologic confirmation was obtained in 11 patients of the 28 shaving excision removal cases.
RESULTS: There was no functional or cosmetic complication in group 1. The wound margin was clear after laser-assisted ablation in all cases. There was one notching of the eyelid, loss of cilia, and two pigmentations in group 2. No infections of the wounds occurred. The average wound epithelialization duration was 3.3 weeks in group 1, significantly faster than 4.2 weeks in group 2. No recurrences occurred during the follow-up period.
CONCLUSIONS: Laser ablation of benign eyelid margin tumors may good alternative option regarding shaving excision biopsy surgery. All patients were satisfied with the cosmetic result. There was no definitive postoperative or intraoperative complication during or after laser application.
Design, Molecular Modelling and Synthesis of Novel Benzothiazole Derivatives as BCL-2 inhibitors
Authors: Ismail Hoda S. , Khalil Amira , Taha Rabah A. , Lasheen Deena S. , Ella Dalal A. Abou El 
Published: March 2023

Abstract
Apoptosis plays a crucial role in cancer pathogenesis and drug resistance. BCL-2 family of enzymes is considered as one of the key enzymes which is involved in apoptosis. When there is disruption in the balance between anti-apoptotic and pro-apoptotic members of the BCL-2 family apoptosis is dysregulated in the affected cells. Herein, 33 novel benzothiazole-based molecules 7a-i, 8a-f, 9a-b, 12a-e, 13a-d, 14a,b, and 17a-j were designed, synthesized and tested for their BCL-2 inhibitory activity. Scaffold hopping strategy was applied in designing of the target compounds. Compounds 13c and 13d showed the highest activity with IC50 values equal to 0.471 and 0.363 µM, respectively. Molecular docking studies for the synthesized compounds showed comparable binding interactions with the lead compound. Structure activity relationship study was performed to show the effects of structural modifications on the inhibitory activities on BCL-2.
Genetic diversity of 1-deoxy-D-xylulose 5-phosphate synthase gene (SmDXS) among the cultivated Danshen (Salvia miltiorrhiza) populations
Authors: Li Guanrong , Ren Ruihua , Feng Jie , Liao Fang , Kong Deying , Yin Yanyan 
Published: March 2023

Abstract
Danshen, a major traditional medicine for cardio-cerebrovascular disorders with a wide range of pharmacological effects, is the radix of herbal Salvia miltiorrhiza Bunge of the genus Salvia and the family Labiatae. It has abundant and more often species unidentified germplasm resources and related alternatives. In recent years, with the advent of more elderly society and the more market demanding, more and more researches have been focused on the cultivation, germplasm resources protection and molecular identification. In this research, 38 cultivated Danshen populations were collected from 30 regions of China. Based on the cDNA gene of the key enzyme 1-deoxy-D-xylulose 5-phosphate synthase (DXS) in the salvianone biosynthetic pathways, degenerate homologous walking primers were designed and the corresponding genomic SmDXS genes were cloned by PCR, sequenced, spliced, and used for bioinformatic analysis, in hope to understand its genetic diversity, to identify novel Danshen materials, and to find specific and traceable SNP fingerprints. Results showed that SmDXS gene is highly conserved. The full-length SmDXS gene in the majority populations (36) was 3383bp, and two (B-JS-V-2 and W-SCHY-W-1), 3374 and 3322 bp respectively; the SmDXS consisted of 10 exons and 9 introns. The spliced exon sequences were all 2157bp in length, with a total of 48 SNP variation sites distributed in 13 populations and a variation rate of 2.23%. The spliced exon sequences encode 718 amino acid residues with 28 amino acid mutations sites in 8 populations. The introns of SmDXS have 224 SNP variation sites, most of which distributed in W-SCHY-W-1. Thirteen populations can be discriminated by SNP fingerprints based on SmDXS gene, with a discriminate rate of 34.2%. Phylogenetic trees based on various parts of the SmDXS gene or deduced proteins showed similar two-clade architectures. Population B-JS-V-2 in full-length SmDXS and combined intron sequences, W-SCHY-W-1 in the spliced exon sequences all stand alone. Populations B-SD-V-2 and V-HBAG-V-1cluster in the deduced amino acid sequences.
Clinical and radiographic evaluation of the implants applied to implant assisted removable partial dentures as surveyed crowns
Authors: Kim You-ra , Lee Jae-Hyun , Lee Su-Young 
Published: March 2023

Abstract
Implant assisted removable partial denture (IARPD) combined with implant surveyed prosthesis has been proposed as a treatment alternative to conventional removable partial denture when additional retention, support and stability are needed in partially edentulous patients. However, a few studies have investigated the implant surveyed crowns applied to IARPDs. This retrospective study was conducted to evaluate implants applied to IARPDs as surveyed crowns clinically and radiographically. This study was performed on patients who treated with IARPD combined with implant surveyed prosthesis from 2015 to 2021. A total of 74 implants applied to 27 IARPDs were evaluated. The factors such as implant location, Kennedy classification, and type of opposite dentition which possibly affected the prognosis of the implants were recorded. The survival rate of the implant and marginal bone resorption around the implant were investigated. The cumulative survival rate of implants applied to IARPD as abutments was 97.30%. The implant survival rates in the maxilla and mandible were 90.47% and 100% respectively and there was a significant difference (p = 0.044). In marginal bone resorption, there was no significant difference for each condition. Properly planned IARPD combined with implant surveyed prosthesis would be an alternative treatment option for partially edentulous patients.
A global just transition through carbon taxation and revenue recycling
Authors: Feng Kuishuang , Chen Xiangjie , Malerba Daniele , Oswald Yannick , Hubacek Klaus 
Published: March 2023

Abstract

Carbon taxation is regarded as an essential tool for curbing carbon emissions but can be regressive and increase poverty, and moreover lacks universal acceptance among the public and policymakers. Recycling the tax revenue raised to vulnerable households is one promising solution to this issue. However, little is known about the best strategy for designing such a policy at the global level. This paper investigates the effectiveness of various carbon taxation methods and revenue recycling mechanisms in reducing poverty and inequality between and within countries. We find that the policy mix with the highest poverty reduction potential is implementing a consumption tax with higher tax rates on luxury goods and recycling revenue through expanded social assistance systems, in line with the expansion during the COVID-19 pandemic. While differentiating tax rates across goods within countries is advantageous, the average tax level across countries is best kept uniform since it potentially offers governments in low- and middle-income countries more financial capacity to support the poor. Furthermore, collecting a global climate fund from developed countries and redistributing it to developing countries based on poverty headcounts can further significantly reduce poverty and inequality within and between countries. However, substantial improvements in social assistance systems are urgently needed to further unlock the poverty-reduction potential of revenue recycling, particularly in Sub-Saharan African countries. Also, recycling carbon tax revenues to combat poverty and inequality will inhibit the emission reduction effect of carbon taxation in the short term, necessitating additional mitigation efforts in other areas.
A Complex for Measuring the Scintillation Index Based on the Results of Gps Monitoring of Small-scale Fluctuations in the Total Electronic Content of the Ionosphere
Authors: Pashintsev V. P. , Peskov M. V. , Senokosov M. A. , Mikhailov D. A. , Skorik D. A. 
Published: March 2023

Abstract
There is the possibility of determining the ionospheric scintillation index by a modified GPStation-6 dual-frequency receiver of GPS/GLONASS global navigation satellite systems by measuring small-scale fluctuations in the total electron content of the ionosphere and calculating their standard deviation. Based on the analysis of the shortcomings of the GPStation-6 receiver, the principle of construction and the algorithm for the functioning of the GPS monitoring complex of small-scale fluctuations of the total electronic content of the ionosphere based on their code-phase measurements and digital filtering to predict the scintillation index is substantiated. Experimental results of measurement of small-scale fluctuations of the ionosphere's total electron content and results of estimation of their root-mean-square deviation and ionospheric scintillation index are presented.
Verification of Anatolian Earthquake on February 6, 2023 Prediction using seismic coefficient analysis
Authors: Shamgani Amir , Saffari Hamid 
Published: March 2023

Abstract
A number of large and deadly earthquake occurred on February 6, 2023, in the vicinity of the Eastern Anatolian Fault, which caused a lot of financial and human losses. This fault runs from the south to the northeast of Turkey, which forms a tectonic boundary between the Arabian plate and the Anatolian plate. Due to the fact that the Arabian plate is moving towards the north and the Anatolian plate is moving towards the west, the mechanism of this fault is strike-slip. In this article, the spatial and temporal changes of seismic parameters in an area with coordinates of 35 to 40 degrees longitude and 35.5 to 39 degrees latitude, which includes the Eastern Anatolian fault, have been investigated. To this purpose, seismic data from 01/01/1990 to 02/21/2023 with a moment magnitude greater than or equal to 3.5 (Mw≥3.5) was considered. This research showed that before large earthquakes occurred on February 6, 2023, the seismicity parameter b clearly decreased. This was happened in the about 6 months before the earthquakes so the b-value had significantly decreased from 3.98 to 0.69. Using spatial and temporal analysis of seismic coefficients besides other pre-detectors such as changes in the amount of stress, wave velocity, gravity characteristics, electric resistance and magnetic field can lead to better prediction of hazardous earthquakes.
Rates of robust superlinear convergence of preconditioned Krylov methods for elliptic FEM problems
Authors: Castillo Sebastian , Karátson János 
Published: March 2023

Abstract
This paper considers the iterative solution of finite element discretizations of second-order elliptic boundary value problems. Mesh independent estimations are given for the rate of superlinear convergence of preconditioned Krylov methods, involving the connection between the convergence rate and the Lebesgue exponent of the data. Numerical examples demonstrate the theoretical results.
Community violence in neighborhoods and common mental disorders among Brazilian adolescents
Authors: Miliauskas Claudia Reis , Hellwig Natalia Hellwig , Bloch Katia Vergetti , Junger Washington Junger , Lopes Claudia de Souza 
Published: March 2023

Abstract

Background: The objectives of this study are to investigate the association between exposure to neighborhood violence and the presence of common mental disorders (CMDs) among Brazilian adolescents aged 12 to 17 years and to analyze whether sex, age and race are modifiers of the effect of this association.
Methods: The study population consisted of 1,686 adolescents living in the municipality of Rio de Janeiro, which is located in the Southeast region of Brazil. To measure exposure to community violence, three crime indicators were created from records at the Civil Police of the State of Rio de Janeiro: crimes against property, nonlethal crimes, and lethal crimes. Geospatial analysis was performed based on the adolescents’ residence area, and logistic regression modeling was performed to measure the association between violence and CMDs.
Results: Adolescents living in regions with higher rates of the three types of violence studied herein were more likely to have CMDs, with odds ratios (ORs) ranging from 2.33 to 2.99. When stratified by sex, age and race, girls, younger adolescents and black individuals had a higher likelihood of having CMDs than their respective counterparts.
Conclusion: This study provides important contributions to the field of public health, as it reveals new information on the influence of community violence on adolescents’ mental health. Given the high rates of violence globally, knowing the effects of violence on adolescents is critical to prevent and treat CMDs in this population.
The use of an RP-HPLC-UV method for the analysis of oxcarbazepine in the presence of its preservatives; stability studies and application to human plasma samples
Authors: Fouad Ali , Abdelkhalek Ahmed S. , Soltan Moustafa K. , Batakoushy Hany A. 
Published: March 2023

Abstract
A simple, sensitive, selective, accurate and precise method was developed and fully validated for determination of oxcarbazepine (OXC) in presence of their preservatives and determination of oxcarbazepine (OXC) in human plasma. A reversed phase liquid chromatography (RP-HPLC) with UV detection techniques were applied for separation and quantification of studied drug OXC. Successful separation of the drug from methyl paraben (M.P.), propyl paraben (P.P.) and potassium sorbate (P.ST.) was achieved on a Kromasil C18 column (5 µm particle size, pore size 300 Å, L × I.D. 250 mm × 4.6 mm). The mobile system that contain aqueous 0.05M potassium dihydrogen phosphate buffer (pH 7): acetonitrile, (50: 50, %v/v). The method was linear over concentration ranges 5.0–50 µg/mL for OXC. Bioanalytical validation of the developed method was carried out according to US-FDA guidelines. The developed method can be applied for routine drug analysis, therapeutic drug monitoring and bioequivalence studies through the analysis of plasma samples taken from blood bank.
Health-related Quality of Life in Chinese Individuals with Type 2 Diabetes Mellitus: A Multicentre Cross-Sectional Study
Authors: Zeng Zihuan , Wang Xingli , Chen Yanhan , Zhou Hengyu , Zhu Wenfen , Xiong Xiu , Tang Jiao , Zhao Qinghua 
Published: March 2023

Abstract
Background: Type 2 diabetes mellitus (T2DM) is a chronic and life-threatening disease. Nevertheless, there are controversies on the factors influencing health-related quality of life (HRQoL) in Chinese individuals with T2DM.
Methods: This multicentre cross-sectional study was conducted in five tertiary grade-A hospitals in Chongqing, China, from January to December 2019. A total of 385 individuals with T2DM were included by the convenient sample method. Fear of Progression Questionnaire-short Form (FOP-Q-SF), Hypoglycemia Fear Survey II(HFSII), diabetes management self-efficacy scale (DESES), and EuroQol-5 Dimensions (EQ-5D) were used for data collection.
Results: The mean age of the 385 individuals was 57.65 (SD = 15.15) years old, and three-quarters of individuals had a high school or above education level. Participants in our study had moderate HRQoL and were more likely to have trouble with the pain/discomfort dimension. The fear of progression (FOP) level was moderate, and 23.1% of individuals suffered from psychological dysfunction. Participants had higher levels of fear of hypoglycemia (FOH) and self-efficacy. Multiple steppage-regression analysis predicted higher levels of FOP and FOH, reduced self-efficacy, older age, longer duration since diagnosis, lower educational attainment, higher level of HbA1c, and living with comorbid conditions were related to lower HRQoL of individuals.
Conclusion: Present research showed that the quality of life of Chinese T2DM patients may be impaired by increased FOP, FOH, and poor glycemic control, due to regional, cultural, and economic differences. In addition, with the increase in the patient's age and duration since diagnosis, the patient's quality of life could further decline. We recommend that improve the quality of life by encouraging patients to attain more health education and resilience skills to enhance self-efficacy and reduce negative emotions of patients.
The influence of photoperiod on development and population growth performance of the Phytoseiulus persimilis fed on Tetranychus urticae
Authors: Pakyari Hajar , Arbab Abbas , Sedaratian-Jahromi Amin 
Published: March 2023

Abstract
Environmental factors, such as photoperiod can play an important role in the development of mites. The influence of photoperiod (L:D= 4:20, 8:16, 12:12, 16:8 and 20:4) on the development and population parameters of the predatory mite, Phytoseiulus persimilis Athias-Henriot fed on two-spotted spider mite, Tetranychus urticae Koch was examined under laboratory conditions. Pre-adult development decreased with increasing photoperiod until 12h, after which development period progressively increased. Longevity of both sexes demonstrated significant differences throughout photoperiods, with the longest at 20:4 L:D and the shortest at 8:16 L:D. The highest value of mean total fecundity was 13.62 egg/female at 12:12 L:D photoperiod. The net reproductive rate (R0), the intrinsic rate of increase (r) and the finite rate of increase (λ), showed the highest value at 12:12 L:D. The R0, r and λ for P. persimilis increased with increasing photoperiod from 4:20 to 12:12 L:D, but decreased sharply at the 16:8 and 20:4 L:D treatments. Our findings indicate that photoperiod has a significant role in advancing the rate of development, survival rate and reproduction for commercial production of P. persimilis, with a 12:12 photoperiod length recognized as the ideal period for commercial production in culture.
Barycentric Lagrange Interpolation in Matrix-Vector Versions for solving Love’s Integral Equations
Authors: Shoukralla E. S. 
Published: March 2023

Abstract
In this paper, we solve two integral equations of Love’s type that have many applications, especially in electrostatic systems. The approach of the solution is based on an innovative technique using matrix algebra for the barycentric Lagrange interpolation. The unknown function is expressed through the product of four matrices, one of which is a square matrix in which each row expresses the coefficients of one barycentric function. The kernel is interpolated twice, so we get the product of five matrices. One of these matrices is the most important matrix in the solution’s procedure. As it expresses the functional values of the kernel at the interpolation nodes for the two variables. Additionally, we derive an equivalent linear algebraic system to the solution by substituting the matrix-vector barycentric interpolated unknown function together with the double interpolation kernel into both sides of the integral equation. The obtained results converge strongly with the approximate analytical solutions. In addition to being uniformly approximated, continuous, and even, which proves the validity of the solution by the presented method.
MSC code: 00A69