bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Society for the Systems Sciences keynote address: Building a global superorganism, a new paradigm for a species in peril
Authors: Corning Peter A. 
Published: September 2023

AbstractThe growth‐oriented economic strategy that has largely prevailed in Western societies over the past two centuries is literally at a dead‐end, along with our global system of independent and sometimes deeply competitive nation states. As we have seen once again with the coronavirus pandemic, as well as the devastating global economic recession and, more important, our rapidly escalating climate crisis, the world is becoming ever more interdependent—and more precarious. We are facing a collective choice like none other in our long, multi‐million‐year history (and prehistory) as a ground‐dwelling bipedal ape. There are only two paths going forward. We must either create a more integrated and cooperative global society and political order or else our species will very likely be consumed by lethal competition and conflict, and perhaps even devolve and go extinct. Only an organized process of cooperative social, economic and political change on a global scale offers us genuine reason for hope. Biologists would call it a “superorganism”—a whole with many parts that are tied together and have a shared fate. The term is commonly used with reference to an integrated, socially organized group in the natural world. Here, I will provide a very brief outline and roadmap for how to achieve a new, more legitimate, and sustainable economic and political world order—a global superorganism. A new social contract will also be required.
Immediate health risk: Concentration of heavy metals in contaminated freshwater fishes from the river channel of Turag‐Tongi‐Balu
Authors: Hossain Md Muzammel , Jahan Iffat , Al Nahian Abdullah , Zhuang Zhipeng , Maxwell Stephen J. , Ali Mohamed Yassin , Sethupathy Sivasamy , Zhu Daochen 
Published: September 2023

AbstractThe consumption of contaminated finfish from the polluted river channel of Turag‐Tongi‐Balu, Kamarpara site, Dhaka poses significant health hazards to humans. We used mass spectrometry on chemically digested liquid samples from five fish species from Turag‐Tongi‐Balu to estimate the concentrations of 10 elements (Cr, Mn, Ni, Cu, Zn, As, Se, Cd, Fe, and Pb). Except M. vittatus, the mean concentrations of Cd, Mn, Pb, and Se exceeded the Food Safety Guideline (FSG) value in all fish species. Among the species studied, L. rohita, C. punctata, C. batrachus, H. fossilis, and M. vittatus exhibited higher Mn concentrations surpassing the FSG threshold, thus elevating the non‐carcinogenic risk across all species. There were statistically significant differences (p < .05) in the mean concentrations of heavy metals among fish species. The Target Hazard Quotient (THQ) value of Mn poses a significant non‐carcinogenic risk to human health, while the hazard of other metals is negligible. Except for M. vittus, the Hazard Index value (HI ≥ 1) revealed the risk that all metals exceed the limit and pose a threat to human health. Cd, As, and Ni metals pose a significant carcinogenic risk to human health from the consumption of fish samples, which is a particularly alarming target cancer risk (TCR). In conclusion, regular dietary consumption of fish from this polluted ecosystem of the Turag‐Tongi‐Balu River channel's Kamarpara site poses a significant health risk and is indicated as cancer. This study emphasizes the significance of monitoring heavy metal contamination in finfish and minimizing the risk to human health with effective measures.
To RNA‐binding and beyond: Emerging facets of the role of Rbfox proteins in development and disease
Authors: Mukherjee Amartya , Nongthomba Upendra 
Published: September 2023

AbstractThe RNA‐binding Fox‐1 homologue (Rbfox) proteins represent an ancient family of splicing factors, conserved through evolution. All members share an RNA recognition motif (RRM), and a particular affinity for the GCAUG signature in target RNA molecules. The role of Rbfox, as a splice factor, deciding the tissue‐specific inclusion/exclusion of an exon, depending on its binding position on the flanking introns, is well known. Rbfox often acts in concert with other splicing factors, and forms splicing regulatory networks. Apart from this canonical role, recent studies show that Rbfox can also function as a transcription co‐factor, and affects mRNA stability and translation. The repertoire of Rbfox targets is vast, including genes involved in the development of tissue lineages, such as neurogenesis, myogenesis, and erythropoeiesis, and molecular processes, including cytoskeletal dynamics, and calcium handling. A second layer of complexity is added by the fact that Rbfox expression itself is regulated by multiple mechanisms, and, in vertebrates, exhibits tissue‐specific expression. The optimum dosage of Rbfox is critical, and its misexpression is etiological to various disease conditions. In this review, we discuss the contextual roles played by Rbfox as a tissue‐specific regulator for the expression of many important genes with diverse functions, through the lens of the emerging data which highlights its involvement in many human diseases. Furthermore, we explore the mechanistic details provided by studies in model organisms, with emphasis on the work with Drosophila.This article is categorized under:
RNA Processing > Splicing Mechanisms
RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications
RNA Turnover and Surveillance > Regulation of RNA Stability
RNA Processing > Splicing Regulation/Alternative Splicing
Putting zoo animal cancer into perspective
Authors: Clauss Marcus , Müller Dennis W. H. 
Published: September 2023

AbstractAs part of a comparative research agenda that promises insights that help extend the human lifespan and combat cancer, cancer prevalence in zoo animals has received recent attention. Here, we want to draw attention to a principle of cancer research that was introduced into the zoo world as early on as 1933, but that seems to have gone somewhat forgotten: Cancer is mainly a disease of old age, and therefore studies aiming at identifying taxa that are particularly susceptible or resistant to cancer must control for whether the respective zoo populations are ‘old.’ In a comparative context, ‘old age’ cannot be measured in absolute terms (e.g., years), but only in relation to a species' maximum lifespan: Species that achieve, across zoos, a higher mean lifespan as a percent of their maximum lifespan are ‘older.’ When applying this metric to former as well as more recently published data on cancer prevalence, it appears that those species that become relatively old in zoos—in particular, the carnivores—have a relatively high cancer prevalence. Any improvement in animal husbandry—which reduces premature deaths—should, by default, lead to more cancer. Cancer in zoo animals, like any other old‐age condition, might therefore be embraced as a proxy for good husbandry. Rather than following a sensationalist approach that dramatizes disease and death per se, zoos should be clear about what their husbandry goals are, what relative longevities they want to achieve for which species, and what old‐age diseases they should therefore expect: in the end, one has to die of something.
Full treatment of the thrust distribution in single inclusive e+e− → h X processes
Authors: Boglione M. , Simonelli A. 
Published: September 2023

Abstract
Extending the transverse momentum dependent factorization to thrust dependent observables entails a series of difficulties, ultimately associated to the behavior of soft radiation. As a consequence, the definition of the transverse momentum dependent functions has to be revised, while preserving (and possibly extending) their universality properties. Moreover, the regularization of the rapidity divergences generates non trivial correlations between rapidity and thrust. In this paper, we show how to deal with these correlations in a consistent treatment of the thrust dependence of e+e− → h X cross section, where the hadron transverse momentum is measured with respect to the thrust axis. In this framework all results obtained in the past few years properly fit together, leading to a remarkable phenomenological description of the experimental measurements.
Superspace expansion of the 11D linearized superfields in the pure spinor formalism, and the covariant vertex operator
Authors: Ben-Shahar Maor , Guillen Max 
Published: September 2023

Abstract
11D pure spinors have been shown to successfully describe 11D supergravity in a manifestly super-Poincaré covariant manner. The feasibility of its actual usage for scattering amplitude computations requires an efficient manipulation of the superfields defining linearized 11D supergravity. In this paper, we directly address this problem by finding the superspace expansions of these superfields, at all orders in θ, from recursive relations their equations of motion obey in Harnad-Shnider-like gauges. After introducing the 11D analogue of the 10D $$ \mathcal{ABC} $$
ABC
superparticle, we construct, for the first time, a fully covariant vertex operator for 11D supergravity by making use of the linearized 11D superfields. Notably, we show that this vertex reproduces the Green-Gutperle-Kwon 11D operators in light-cone gauge.
Genomic prediction in hybrid breeding: II. Reciprocal recurrent genomic selection with full-sib and half-sib families
Authors: Melchinger Albrecht E. , Frisch Matthias 
Published: September 2023

AbstractKey messageGenomic prediction of GCA effects based on model training with full-sib rather than half-sib families yields higher short- and long-term selection gain in reciprocal recurrent genomic selection for hybrid breeding, if SCA effects are important.AbstractReciprocal recurrent genomic selection (RRGS) is a powerful tool for ensuring sustainable selection progress in hybrid breeding. For training the statistical model, one can use half-sib (HS) or full-sib (FS) families produced by inter-population crosses of candidates from the two parent populations. Our objective was to compare HS-RRGS and FS-RRGS for the cumulative selection gain ($$\Sigma \Delta G$$ΣΔG), the genetic, GCA and SCA variances ($$\sigma_{G}^{2}$$σG2,$$\sigma_{gca}^{2}$$σgca2,$$\sigma_{sca}^{2}$$σsca2) of the hybrid population, and prediction accuracy ($$r_{gca}$$rgca) for GCA effects across cycles. Using SNP data from maize and wheat, we simulated RRGS programs over 10 cycles, each consisting of four sub-cycles with genomic selection of$$N_{e} = 20$$Ne=20out of 950 candidates in each parent population. Scenarios differed for heritability$$\left( {h^{2} } \right)$$h2and the proportion$$\tau = 100 \times \sigma_{sca}^{2} :\sigma_{G}^{2}$$τ=100×σsca2:σG2of traits, training set (TS) size ($$N_{TS}$$NTS), and maize vs. wheat. Curves of$$\Sigma \Delta G$$ΣΔGover selection cycles showed no crossing of both methods. If$$\tau$$τwas high,$$\Sigma \Delta G$$ΣΔGwas generally higher for FS-RRGS than HS-RRGS due to higher$$r_{gca}$$rgca. In contrast, HS-RRGS was superior or on par with FS-RRGS, if$$\tau$$τor$$h^{2}$$h2and$$N_{TS}$$NTSwere low.$$\Sigma \Delta G$$ΣΔGshowed a steeper increase and higher selection limit for scenarios with low$$\tau$$τ, high$$h^{2}$$h2and large$$N_{TS}$$NTS.$$\sigma_{gca}^{2}$$σgca2and even more so$$\sigma_{sca}^{2}$$σsca2decreased rapidly over cycles for both methods due to the high selection intensity and the role of the Bulmer effect for reducing$$\sigma_{gca}^{2}$$σgca2. Since the TS for FS-RRGS can additionally be used for hybrid prediction, we recommend this method for achieving simultaneously the two major goals in hybrid breeding: population improvement and cultivar development.
Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin
Authors: Ramirez-Hincapie Sabina , Birk Barbara , Ternes Philipp , Giri Varun , Zickgraf Franziska Maria , Haake Volker , Herold Michael , Kamp Hennicke , Driemert Peter , Landsiedel Robert , Richling Elke , Funk-Weyer Dorothee , van Ravenzwaay Bennard 
Published: September 2023

AbstractOmics techniques have been increasingly recognized as promising tools for Next Generation Risk Assessment. Targeted metabolomics offer the advantage of providing readily interpretable mechanistic information about perturbed biological pathways. In this study, a high-throughput LC–MS/MS-based broad targeted metabolomics system was applied to study nitrofurantoin metabolic dynamics over time and concentration and to provide a mechanistic-anchored approach for point of departure (PoD) derivation. Upon nitrofurantoin exposure at five concentrations (7.5 µM, 15 µM, 20 µM, 30 µM and 120 µM) and four time points (3, 6, 24 and 48 h), the intracellular metabolome of HepG2 cells was evaluated. In total, 256 uniquely identified metabolites were measured, annotated, and allocated in 13 different metabolite classes. Principal component analysis (PCA) and univariate statistical analysis showed clear metabolome-based time and concentration effects. Mechanistic information evidenced the differential activation of cellular pathways indicative of early adaptive and hepatotoxic response. At low concentrations, effects were seen mainly in the energy and lipid metabolism, in the mid concentration range, the activation of the antioxidant cellular response was evidenced by increased levels of glutathione (GSH) and metabolites from the de novo GSH synthesis pathway. At the highest concentrations, the depletion of GSH, together with alternations reflective of mitochondrial impairments, were indicative of a hepatotoxic response. Finally, a metabolomics-based PoD was derived by multivariate PCA using the whole set of measured metabolites. This approach allows using the entire dataset and derive PoD that can be mechanistically anchored to established key events. Our results show the suitability of high throughput targeted metabolomics to investigate mechanisms of hepatoxicity and derive point of departures that can be linked to existing adverse outcome pathways and contribute to the development of new ones.
Mean Bone Material Strength Index Values for Women are Lower Than Those for Men: Data from a Single Geographical Location
Authors: Holloway-Kew Kara L. , Rufus-Membere Pamela G. , Anderson Kara B. , Harland Jacob W. , Diez-Perez Adolfo , Kotowicz Mark A. , Pasco Julie A. 
Published: September 2023

AbstractBone material strength index (BMSi) values are obtained using impact microindentation, which assesses the ability of bone to resist indentation. Differences in BMSi between men and women are unclear, and to date, BMSi sex differences have not been compared for individuals from the same population. Therefore, we compared BMSi values for men and women drawn from the same geographical location in Australia. Participants (n = 220) were from the Geelong Osteoporosis Study. BMSi was measured, following international published guidelines, using an OsteoProbe for participants at recent follow-up phases (women 2022–2023 and men 2016–2022). Women (n = 55) were age matched to men (n = 165) in a 1:3 ratio. A two-sample t test was used to determine the intergroup difference in mean BMSi. Linear regression was also performed, adjusting for weight and height. Median (IQR) ages for men and women were 67.0 (61.7–71.5) and 67.4 (62.0–71.2) years (p = 0.998). Men were heavier (81.0 ± 10.9 vs 71.0 ± 13.9 kg, p < 0.001) and taller (173.9 ± 6.4 vs 161.5 ± 7.5 cm, p < 0.001) than women. Mean (± SD) BMSi for women (75.7 ± 7.4) was lower than for men (82.8 ± 6.8) (p < 0.001). The difference persisted after adjustment for weight and height (mean ± SE: 76.5 ± 1.1 vs 82.5 ± 0.6, p < 0.001). Given the higher fracture risk observed for women, the higher mean BMSi values in men are consistent with cross sectional data suggesting this measure may be useful in fracture prediction.
Health-related quality of life in children with congenital vascular malformations
Authors: Bouwman Frédérique C. M. , Verhaak Chris , de Blaauw Ivo , Kool Leo J. Schultze , Loo D. Maroeska W. M. te , van Rooij Iris A. L. M. , van der Vleuten Carine J. M. , Botden Sanne M. B. I. , Verhoeven Bas H. 
Published: September 2023

AbstractA cross-sectional study was performed to evaluate health-related quality of life (HRQOL) in children with congenital vascular malformations (CVM) and to investigate factors associated with an impaired HRQOL. Children (2–17 years) with CVMs who visited the HECOVAN expertise center between 2016–2018 were included. The PedsQL 4.0 Generic Core Scales were used and a score ≥ 1.0 SD below the normative mean was defined as an impaired HRQOL. Factors associated with impairment were investigated using univariate and multivariate logistic regression analysis. The median overall HRQOL was 84.8/100 (n = 207; 41% boys, 59% girls; self-reported IQR 73.9–92.4 and parent-reported IQR 71.4–92.4). Patients aged 13–17 years reported significantly worse physical functioning than those aged 8–12 years (median 84.4, IQR 71.1–93.8 versus median 90.6, IQR 81.3–96.9; p = 0.02). Parents reported a significantly lower overall HRQOL than their children (median 80.4, IQR 70.7–90.8 versus median 85.9, IQR 76.1–92.4; p = 0.001). HRQOL was impaired in 25% of patients. Impairment occurred significantly more often in lower extremity CVMs (38%, p = 0.01) and multifocal CVMs (47%, p = 0.01) compared to CVMs in the head/neck region (13%). Other associated factors included invasive management (31% versus 14%; p = 0.01), age at first treatment ≤ 5 years (48% versus 25%; p = 0.02) and ongoing treatment (38% versus 18%; p = 0.004). After correction for other factors, significance remained for lower extremity CVMs and ongoing invasive treatment.Conclusions: Overall median HRQOL was reasonable and not significantly different from the norm sample. Parental ratings were significantly lower than their children’s ratings. A quarter of the patients had an impaired HRQOL, which seemed to worsen with age. Independently associated factors included a lower extremity CVM and invasive management.

What is Known:• Congenital vascular malformations could affect health-related quality of life (HRQOL).• Studies on pediatric patients are limited and either very small or in combination with adult patient series.

What is New:• This study raises awareness of an impaired HRQOL in 25% of pediatric patients with congenital vascular malformations.• Associated factors included a lower extremity CVM and invasive management.
Myco-remediation of plastic pollution: current knowledge and future prospects
Authors: Khatua Somanjana , Simal-Gandara Jesus , Acharya Krishnendu 
Published: September 2023

AbstractTo date, enumerable fungi have been reported to participate in the biodegradation of several notorious plastic materials following their isolation from soil of plastic-dumping sites, marine water, waste of mulch films, landfills, plant parts and gut of wax moth. The general mechanism begins with formation of hydrophobin and biofilm proceding to secretion of specific plastic degarding enzymes (peroxidase, hydrolase, protease and urease), penetration of three dimensional substrates and mineralization of plastic polymers into harmless products. As a result, several synthetic polymers including polyethylene, polystyrene, polypropylene, polyvinyl chloride, polyurethane and/or bio-degradable plastics have been validated to deteriorate within months through the action of a wide variety of fungal strains predominantly Ascomycota (Alternaria, Aspergillus, Cladosporium, Fusarium, Penicillium spp.). Understanding the potential and mode of operation of these organisms is thus of prime importance inspiring us to furnish an up to date view on all the presently known fungal strains claimed to mitigate the plastic waste problem. Future research henceforth needs to be directed towards metagenomic approach to distinguish polymer degrading microbial diversity followed by bio-augmentation to build fascinating future of waste disposal.
A Logical Study of Moral Responsibility
Authors: Duijf Hein 
Published: September 2023

AbstractThis paper proposes a logical framework for studying the structure of moral responsibility for outcomes. The analysis incorporates two vital features: an agency condition and a negative condition of an alternative possibility. The logical language allows us to identify and disambiguate seven plausible criteria for moral responsibility. To accommodate interdependent decision contexts, the semantics are given in terms of so-called responsibility games. The logical framework enables us to classify the logical relations between these seven criteria for moral responsibility. Although all seven criteria are logically distinct, I also identify circumstances where the seven criteria locally reduce to only three.
In Search for Optimal Methods: New Insights About Meta-Induction
Authors: Schurz Gerhard 
Published: September 2023

AbstractIn this paper, the contributions to the account of meta-induction (Schurz 2019) collected in this volume are critically discussed and thereby, new insights are developed. How broad and expandable the program of meta-induction is can be learned from Ortner’s contribution. New insights about the transition from the a priori justification of meta-induction to the a posteriori justification of object-induction emerge from the reflection of Shogenji’s paper. How meta-induction may be applied also to religious prophecies and that their meta-inductive justification does not fail for a priori reasons but because of missing evidence for predictive success is learned from the discussion of Pitts’ contribution. That meta-induction does not rely on a particular prior distribution, while the no free lunch theorem depends implicitly on a uniform prior, is the major conclusion drawn from the discussion of Wolpert’s article. How the problem of induction is treated in different versions of the Bayesian account is learned from the discussion of Willliamson’s paper. That meta-induction can also be employed for abduction, and that abductive theory-revision can offer meta-inductive aggregation methods is a new insight emerging from the reflection of Aliseda’s contribution.