bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silk-Derived Protein-4 (SDP-4) versus a novel sodium acetate vehicle in the treatment of patients with moderate to severe dry eye disease: a randomized, dual cohort, controlled trial
Authors: Lawrence Brian D. , Karpecki Paul M. , Levy Brian , Infanger David W. 
Published: September 2023

Abstract
Background: Dry eye disease (DED) affects over 400 million people globally, with 120 million Americans spending $3 billion per year on eye drops to treat their symptoms that significantly reduce their quality of life from reduced vision and chronic suffering. There is a significant unmet need for products that provide both immediate relief and long-term symptom reduction. The amphiphilic, mucin-like, chemistry of silk-derived protein-4 (SDP-4) enhances coating on the ocular surface to improve tear film stability and comfort. Additionally, previous studies support that both SDP-4 and sodium acetate inhibit inflammation, which is a known and significant driver of DED symptomatology.
Methods: Preservative free eye drops were formulated with sodium acetate buffer as a vehicle, in which SDP-4 was added at 0.1%, 1%, and 3% wt./wt. concentrations. The product was evaluated in an exploratory Phase 2 clinical study that compared the treatment effect of SDP-4 vs vehicle in patients with moderate-to-severe or only moderate baseline symptomatology (N = 456, n1=305, n2=151). Patients were dosed twice daily (BID) for a period of up to 84 days.
Results: The best performing dosing arm, 1% SDP-4, increased tear film stability and reduced DED symptoms by the first week of treatment with continued reduction in symptoms through the 84-day study period. The treatment significantly increased the DED sign of Tear Breakup Time (TBUT) vs the vehicle control (P<0.05) at days 28 and 56. TBUT is an accepted measure of tear film stability. Furthermore, patient symptomatology from baseline was reduced by 46% based on subjectively reported Symptom Assessment iN Dry Eye (SANDE) visual analog scale (VAS) scores at day 84. Most importantly, patients with severer baseline DED experienced a significantly greater reduction in symptomatology than patients with moderate baseline DED (P<0.01). For all patients, SDP-4 and the vehicle was well tolerated throughout the study with a low 2.6% discontinuation rate.
Conclusions: The favorable combination of safety, comfort, and symptom reduction positions SDP-4 sodium acetate formulations as an innovative approach for treating DED by simultaneously providing immediate comfort at use, and addressing the symptomatology in the difficult to treat severe DED patient population.
Trial registration
Name of registry: www.ClinicalTrials.gov
Trial registration numbers: NCT03889886 (first cohort) and NCT04535947 (second cohort)
Date of registration: March 26, 2019
URL of trial registry record: clinicaltrials.gov/ct2/show/NCT03889886 (first cohort) and clinicaltrials.gov/ct2/show/NCT04535947 (second cohort)
Behavioral Analysis-based Labeling for Physical Exercise Posture Image Dataset using National Artificial Intelligence Computing Platform
Authors: Lee Byung-Gook , Ulziisaikhan Ulziichimeg , Heo Seoyoon , Choi Wansuk 
Published: September 2023

Abstract
Recently, research on physical fitness posture estimation in the virtual space using artificial intelligence (AI) has been actively conducted. However, AI has been difficult due to a lack of fitness datasets and guidelines. To advance fitness posture estimation algorithm through analyzing fitness image provided by national artificial intelligence Platform known as AI-Hub (powered by National Information society Agency, NIA) in Korea and approaching it wider and deeper from the perspective of exercise prescription vacation and behavioral analysis. Through this advancement, this study intended to closely analyze fitness movements and guide correct exercise posture with screen and sound. Referring to image and labeling JSON (JavaScript Object Notation) file provided by AI-Hub, contents necessary and useful for the posture estimation algorithm from the perspective of exercise prescription were explained in writing, diagrams, and photos. The structure of data for 6 million consecutive and diverse fitness images and labeling data of scenes was analyzed. In addition to existing explanation, exercise state and posture of exercise in the data structure of 41 fitness images were analyzed and presented in detail. In addition, annotation and labeling characteristics were explained in detail with photo images.
Conclusion: Detailed description and introduction of fitness image analyzed in this study would help developers of exercise coach web/ app services use fitness images by upgrading posture estimation algorithms using AI.
BwMMV-pred: A Novel Ensemble learning approach using blood smear images for Malaria Prediction
Authors: Tayyeb Arabi , Alim Muhammad Affan , Alam Mansoor , Su’ud Mazliham Mohd 
Published: September 2023

Abstract
The utilization of machine learning in healthcare is widespread, aiding doctors and clinicians in various capacities. One of the critical implementations of machine learning in healthcare is the creation of an automated diagnosis system capable of predicting outcomes equivalent to or surpassing those of human experts. This study illustrated the optimistic outcomes using the proposed Blending with Meta Majority Voting (BwMMV) method as a cutting-edge and highly effective ensemble learning technique. Essentially, the Local Binary Pattern Histogram (LBPH), a straightforward and effective texture operator, was utilized to convert the blood smear images into their underlying texture characteristics. The proposed approach BwMMV involves creating a new dataset by using the predictions generated by the 8 base classifiers, also known as an intermediate dataset. This intermediate dataset is then used to develop five additional models using 5 distinct machine-learning algorithms, called meta-models. The final decision is made using a majority voting technique, where the outcome with the highest number of votes is selected as the final choice. The proposed technique has been found to be highly effective and resilient in terms of both performance and robustness. It has been demonstrated to be a superior approach for an automatic diagnosis system when compared to conventional hard voting and blending techniques.
Water quality monitoring in southern Brazil and the assessment of risk factors related to contamination by coliforms and Escherichia coli
Authors: Nascimento Santos Nathalia Geovana , Silva Luana Carvalho , Guidone Gustavo Henrique Migliorini , Montini Victor Hugo , Dias Oliva Bruno Henrique , Nascimento Arthur Bossi , de Sousa Diana Nara Ribeiro , Kuroda Emília Kiyomi , Rocha Sergio Paulo Dejato 
Published: September 2023

Abstract

The potability of water, including underground sources, is constantly affected by human activities. To assess water quality and water security in rural and urban areas of southern Brazil, a quantitative, retrospective analysis of water samples collected monthly by the Brazilian health authorities (19,687 samples from 2013 to 2021) was performed. In rural areas, 5,979 water samples (77.54%) were found to be contaminated by coliform bacteria and 3,431 (44.50%) by Escherichia coli. In addition, 1,616 (20.95%) of the contaminated samples were significantly correlated with rainfall amount. In urban areas, 1,268 (10.95%) of the samples contained coliform bacteria and 293 (2.53%) of these samples contained E. coli, with the factor of rainfall associated with 1,081 samples (9.33%) with bacterial contamination. In terms of physicochemical parameters, turbidity exceeded the national standard (5 uT) in 448 (2.32%) samples and fluoride fell below the required level (0.8 mg/L) in 106 samples (0.54%). The presence of free residual chlorine (0.2–2.0 mg/L) was verified in 846 samples (14.38%) in rural areas and in 10,825 samples (56.13%) in urban areas. These results suggest a strong association between rainfall factors and physicochemical alterations, as well as the risk of greater microbial contamination of water for human consumption.
Influence of COVID 19 on Nursing Students’ Career Identity: A Cross-sectional Study
Authors: Kim Na-geong , Park Hye-Ryeon 
Published: September 2023

Background:
The Coronavirus disease 2019 has affected students’ education because they are more likely to be exposed to such infectious diseases during clinical practice in hospitals. This may result in inaccurate knowledge of coronavirus disease 2019 among nursing students and foster negative attitudes and fears about the virus, potentially resulting in negligent patient care.

Objective:
This study elucidates the relationship between nursing students’ knowledge, attitude, and fear of coronavirus disease 2019 and their career identity.

Methods:
We used structured self-reported questionnaires to assess knowledge, attitude, and fear about Coronavirus disease 2019 and career identity among 223 nursing students. We analyzed data using a t-test, Pearson’s correlation coefficient, and stepwise multiple regression.

Results:
Satisfaction with the actual clinical practice (β=0.35, p<0.001), knowledge of coronavirus disease 2019 (β=.25, p<.001), attitude toward coronavirus disease 2019 (β=.17, p=.002), and fear of coronavirus disease 2019 (β=.39, p<.001) influenced students nurses’ career identity.
Career guidance programs are needed to positively transform nursing students’ fear of Coronavirus disease 2019, to enhance their career identity. Educational content that can be used during clinical practice should be developed, to improve professional knowledge. Thus, the nursing students’ satisfaction with practice can be nurtured with a change of attitude toward infectious diseases. Besides active efforts and institutional arrangements at the national level, cooperation and feedback between schools and hospitals are important for nursing students to form a desirable career identity.

Conclusion:
Nursing students’ fear, knowledge, and attitude toward Coronavirus disease 2019 and satisfaction with the practice influence career identity. Moreover, it is necessary to develop educational content that can be used during clinical practice and improve professional knowledge. This will nurture the student nurses’ practice satisfaction and induce a change in attitude toward infectious diseases. Cooperation and feedback between schools and hospitals are of paramount importance for student nurses to form a desirable career identity, in addition to active efforts and institutional arrangements at the national level.
Experiencias cotidianas de mujeres diagnosticadas con hipertensión arterial sistémica residentes de la Ciudad de México
Authors: Fernández García María Victoria 
Published: September 2023

Introducción: La elevada prevalencia de hipertensión arterial sistémica es un problema de salud pública a nivel mundial. Se requiere profundizar, desde una perspectiva crítica, acerca de los aspectos que subyacen a la falta de control y en la complejidad de los contextos de pobreza.Objetivo: Analizar desde una perspectiva crítica la configuración de la experiencia y el significado de padecer hipertensión, en tres casos de mujeres que habitan en un contexto multicultural, de pobreza y trabajo agrícola de Ciudad de México.Metodología: Estudio de corte etnográfico, con seguimiento de más de dos años a tres mujeres en sus contextos. Se realizó observación participante, entrevistas en profundidad e informales. El análisis de las entrevistas fue desde la fenomenología crítica. Resultados: Se identificaron las categorías: inicio y malestares; experiencia de la enfermedad (vida cotidiana). Los resultados mostraron complejos entramados que reflejan las tensiones y dinámicas derivadas de contextos de pobreza estructural y de género. La enfermedad fue atendida en crisis como resultado de la cultura somática, configurada por las condiciones materiales de vida que definen la búsqueda de atención. Discusión y Conclusiones: La investigación muestra la sinergia de diferentes factores de los contextos que derivan en la falta de atención y en una cultura somática en la que se normalizan los malestares, la enfermedad, así como la desigualdad de género. La experiencia de la enfermedad fue modulada predominantemente por la situación económica y el género.
Trata con fines de explotación sexual en México: La mercantilización del cuerpo de las mujeres
Authors: Hernández-Gutiérrez Regina Isabel 
Published: September 2023

La trata de personas es un fenómeno presente de forma global. En México, la que se lleva a cabo con fines de explotación sexual, cuenta con un mayor porcentaje de víctimas identificadas, quienes; además, son mujeres y niñas principalmente. Esto conlleva a colocar sobre la mesa de discusión que la identidad y corporeidad de las mujeres sigue atravesada por constructos sociales que devienen de un sistema y cultura patriarcal, que las hace objetos y deshumaniza para uso y placer de otros. Aunado a ello, se encuentra el sistema capitalista que ha encontrado en esta práctica una veta de ganancias para la acumulación al convertir a estas mujeres en mercancías. De esta manera, en la trata con fines de explotación sexual, se concreta la relación existente entre capitalismo y patriarcado al ser el cuerpo de las mujeres ya no sólo objeto de placer, sino mercancía que puede ser vendida al mejor postor. Para el presente artículo, en cuanto a la metodología, se recurrió a la revisión bibliográfica de informes y diagnósticos sobre el tema, ya que es un estudio documental. Asimismo, el análisis de los más recientes informes publicados sobre el tema en México, permite hacer énfasis en la situación de las mujeres como víctimas de trata con fines de explotación sexual, dado que el informe global del 2020, señalaba una presencia mayor de este grupo en esta modalidad de trata. De esta manera, es posible sustentar que la explotación sexual se basa en el uso de los cuerpos femeninos y es una forma de violencia.
Pemanfaatan Bonggol Jagung Sebagai Bahan Campuran Pembuatan Paving block Porous
Authors: Pratama Firmansyah Ully , Rahmawati Winda , Wisnu Febryan Kusuma , Suharyatun Siti 
Published: September 2023

The development needs of the population that continues to increase cause a mismatch in land use. This can make it possible to reduce water catchment areas in any areas with dense building growth. The use of cement in both housing and road construction results in reduced water absorption areas because cement has properties that make it difficult to absorb water, so water will become stagnant. Therefore, a cement substitute is needed to cover the shortage of cement. The addition of corn cobs in the paving block mortar is expected to increase its water absorption without reducing the compressive strength of the paving blocks. This is done to reduce corn cob waste and save on staple food costs. as well as being used as a useful product innovation in reducing corn cob waste. After printing is complete, the porous paving blocks are dried in the sun and conditioned for approximately 21 days, then the porous paving blocks are ready to be tested. The experimental design consisted of 4 treatments, namely C1, C2, C3, and C4. For the density test, values were obtained with an average of 1.327 g/cm3 – 1.628 g/cm3. For the infiltration test, a value of 0.274 mm/s was obtained. Whereas the visible test is obtained with the appropriate form of paving texture obtained on factor C4 because the resulting texture is good and there are no gaps or defects when the paving has been printed. The highest value from the water absorption test occurred in the C4 treatment with a value of 23.91%. The effect of corncob waste on Porous Paving Blocks in this study is that the more corncob waste fiber is used, the more porous paving block cavities will be, and vice versa if using less corncob waste fiber, the pore cavities will be larger. produced on porous paving blocks will be less. Keywords: Corn Cogs, Paving block Porous.
Yağış-Akış İlişkisinin GEP ve ANFIS İle Modellenmesi
Authors: YAMAN Yunus , ÖNEN Fevzi 
Published: September 2023

Yağış-akış ilişkisinin doğru bir şekilde modellenmesi, su kaynaklarının yönetimi ve su taşkınlarının kontrolü gibi hidrolojik uygulamalar için hayati önem taşımaktadır. Ancak hidrolojik sistemlerin karmaşıklığı ve nonlineer özellikleri nedeniyle, yağış-akış ilişkisi gibi olayları tanımlamak için hala birçok model geliştirilmektedir. Özellikle son yıllarda küresel ısınma ve küresel iklim değişimi gibi etmenler, yağış-akış ilişkisini belirlemeyi daha da önemli hale getirmiştir. Bu nedenle, yapay zeka teknikleri gibi modern yaklaşımların kullanımı giderek artmaktadır.
Bu çalışmada, havza yağış-akış modellemesi için iki farklı yapay zeka tabanlı yöntem olan Genetik İfadeli Programlama (GEP) ve Uyarlanabilir Sinirsel-Bulanık Çıkarım Sistemi (ANFIS) kullanılarak, tahmin edilen akış değerleri gözlenen akış değerleri ile karşılaştırılmıştır. Girdi parametreleri olarak, uydu verilerinden elde edilen 4km x 4km çözünürlüklü yağış verisi kullanılmıştır. Bu yağış verisi, havza için günlük ortalama yağış yüksekliği olarak elde edilmiştir. Akım verisi olarak, Berta Suyu Havzası çıkışındaki EİE-2334 nolu akım gözlem istasyonunun (AGİ) günlük akış verileri kullanılmıştır. Akım verileri, Q(t-1), Q(t-2), Q(t-3), Q(t-4) ve yağış verileri olan P(t), P(t-1), P(t-2), P(t-3) gibi çeşitli girdi senaryoları oluşturulmuş ve çıkış olarak Q(t) ile eşleştirilmiştir. Modellerin performansı, determinasyon katsayısı (R2) ve ortalama karesel hatanın kökü (KOKH) gibi istatistiksel ölçütler kullanılarak değerlendirilmiştir. Yapılan çalışmada, ANFIS ve GEP yöntemlerinden elde edilen sonuçların birbirine yakın olduğu tespit edilmiştir. Berta Suyu Alt Havzası için en yüksek R2=0,988 ve en düşük KOKH=4,770 değerini veren modelin ANFIS-K1 olduğu görülmüştür. Bu sonuçlar, yapay zeka tekniklerinin yağış-akış ilişkisini belirlemede etkili bir araç olduğunu göstermektedir.
The use of nanorobots in the oil and gas industry
Authors: Kartoev Magomed-Amin Mikailovich , Shevyakhova Elena Andreyevna , Lyamina Natalya Fyodorovna 
Published: September 2023

In order to increase oil recovery in oil fields the possibilities of using reservoir nanorobots in the oil and gas industry have been investigated. Nanorobots are micro- and nanomechanical systems capable of being injected into an oil reservoir to study and modify its properties. The main attention is paid to solving the problem of oil availability in the reservoir which is achieved by creating mechanical channels and changing the physico-chemical characteristics
of oil words, taking into account key factors - the reliability and durability of nanorobots, their ability to work in extreme field conditions. The importance of developing a specialized infrastructure for effective management and control of nanorobots, including software, as well as a communication system for data exchange between nanorobots, is emphasized. The ability of nanorobots to interact with each other and solve problems related to the optimization of oil production processes is considered. It is noted that nano-robots can be used to study and monitor the condition of wells, enhance production processes, improve the properties of materials, as well as in repair work. Before using this technology widely in the oil and gas industry, it is necessary to carry out a detailed study in order to determine the optimal methods of implementation and to solve issues of safety and reliability of such a system.
Compilation of data on optimizing tubular furnaces operation
Authors: Lysova Vera Nickolaevna , Khaibulov Rishad Abdulhakimovich 
Published: September 2023

A great number of processing hydrocarbon raw material units operated at enterprises have heat exchangers of different designs. A significant share among them comes to the special heat exchangers that use the heat of exhaust gases when burning liquid and gaseous fuels – tubular furnaces. Depending on the specifics and type of fuel used, the furnaces differ both in design and in operational parameters. At AT units, AVT units, and gasoline secondary distillation units, HFC furnaces are used to heat hydrocarbon media and are characterized by heating temperatures from 300C° to 500°C. In the units of technological processes of pyrolysis, conversion of hydrocarbon gases, etc., simultaneously with heating and/or overheating of the raw materials, furnaces are used as reactors. The effective use of such furnaces is possible only if there are used engineering methods predicting changes in the technological flow, created on the basis of reliable analytical and experimental materials. The available data is insufficient to develop measures
to improve the efficiency and reliability of these units. There are discussed the results of analytical studying the optimizing the operation of tubular furnaces, identified the main disadvantages during their operation, determined methods for assessing the wear of the elements of the apparatus depending on the technological modes (temperature, pressure, medium) and the material of execution in the process of technical diagnostics of equipment to ensure industrial safety. The issues of the influence of design features and of organizing the combustion process of nozzles on the quality indicators of tubular furnaces are considered. The main directions of increasing the energy efficiency of radiant and convection chambers of tubular furnaces are defined.
Makedonya Örme Kültüründe Hayvan Figürlü Çoraplar
Authors: EROĞLU Mehmet Ali , AKPINARLI Feriha 
Published: September 2023

Türk sanatının kökenleri Orta Asya Bozkırlarından başlayarak, günümüz Anadolu topraklarına ve Balkanlara kadar uzanmaktadır. Uzun yıllar Osmanlı hakimiyetinde kalan Balkan coğrafyasının bir çok ülkesinde Türk sanatının izlerini görmek mümkündür. Türk sanatının Balkanlarda uzun bir süre görüldüğü ülkelerden birisi de Makedonya’dır. Özellikle Üsküp, Osmanlı Mimari eserlerinin günümüze kadar ulaştığı ve Osmanlı el sanatlarının görüldüğü bir yerleşim yeridir. Osmanlı’nın Balkanları fethi ile birlikte Anadolu’dan Balkanlara kültür-sanat göçü de yaşanmıştır. Bu kültür-sanat göçüyle Kuzey Makedonya’da Osmanlı sanatının izleri görülmüştür. Bu izler günümüzde Kuzey Makedonya’nın önemli simgelerinden biri olan Üsküp Türk Çarşısında günümüze kadar devam etmektedir. Üsküp Türk çarşısında, Türk el sanatlarının izlerinin görüldüğü birçok işyeri bulunmaktadır. Bu iş yerlerinde gerek Türk kültürü gerekse Balkan kültürünün özelliklerini yansıtan ürünlerin teşhir ve satışı yapılmaktadır. Mayıs 2022’de Türk sanatının Balkanlardaki izlerini tespit etmek amacıyla Kuzey Makedonya’da Üsküp ve Kalkandelen, Kosova’da Prizren ve Priştine, Karadağ’da ise Rojea, Akova ve Berane bölgelerinde alan araştırması yapılmıştır. Alan araştırmasının bir bölümünü oluşturan Kuzey Makedonya Üsküp çarşısında Türk kültürü ile benzerlik gösterebilecek örme çoraplar ve el dokumaları ile ilgili araştırmalar yapılmıştır. Alan araştırması esnasında Hamza Murat isimli koleksiyonerin örme çorap arşivi fotoğraflanarak incelenmiştir.
Bu çalışmada Kuzey Makedonya folklorunun bir parçası olan el örmesi hayvan figürlü çoraplar; desen, renk, kompozisyon, hammadde ve teknik özellikleri açısından incelenmiş, literatür bilgileri ile desteklenerek kataloglanmıştır.