bluuebunny/crossref_metadata_2025_split huggingface dataset:
The heart‐lung machine in major limb replantation: Report of two cases
Authors: Wan Ismail Wan Faisham Numan B. , Bin Wan Sulaiman Wan Azman , Saad Arman Zaharil Bin Mat , Mokthar Ariffin Marzuki Bin , Paiman Mohammad Bin , Jusoh Mohd Hanifah Bin , Mamat Ahmad Zuhdi Bin , Eu Chong Soon 
Published: July 2023

AbstractReplantation of amputated limbs after long ischemic hours almost always comes with reperfusion syndrome and poor outcomes. An ischemic time of greater than 6 h is often considered unsuitable for major limb replantation. However, usage of extracorporeal perfusion has been shown to prolong the viability of major limbs in animal studies. The aim of this report is to show that extracorporeal perfusion with cardiopulmonary bypass machine (CPBM) is a safe and reliable technique in improving limb survival as illustrated by our cases. We report two cases of successful major limb replantation with late presentation. One case involved a 31‐year‐old man with shoulder disarticulation and the other involved a 30‐year‐old man sustained proximal transtibial amputation. Both patients, who were generally fit, were involved in major road traffic accidents. The amputated segments were connected to a CPBM to expedite reperfusion and to flush away anaerobic metabolic products. The major vessels were cannulated and connected to a bypass machine that was initially primed with heparinized saline and perfused with packed cells at 100% oxygen concentration. The perfusion was carried out at 35°C with low pressure to prevent edema and low flow to reduce reperfusion injury. Venous blood was drained completely before replantation. Total ischemia times were 7 h 40 min and 9 h, respectively. No evidences of perioperative reperfusion syndrome were seen. Both of the replanted limbs survived and patients had regained better‐than‐expected limb functional outcomes at 5‐year and 2‐year follow‐up, respectively. CPBM may be safely used in major replantation surgery to enhance limb survival and therefore warrants further research.
Extension Region Domain of Soybean 7S Globulin Contributes to Serum Triglyceride‐Lowering Effect via Modulation of Bile Acids Homeostasis
Authors: Han Kaining , Feng Guangxin , Li Tanghao , Wan Zhili , Zhao Wenjing , Yang Xiaoquan 
Published: July 2023

ScopeSoybean 7S globulin (β‐conglycinin), a major soybean storage protein, has been demonstrated to exert remarkable triglyceride (TG) and cholesterol‐lowering effects, yet the underlying mechanism remains controversial.Methods and resultsA comparative investigation is performed to assess the contribution of different structural domains of soybean 7S globulin, including core region (CR) and extension region (ER) domains, to biological effects of soybean 7S globulin using a high‐fat diet rat model. The results show that ER domain mainly contributes to the serum TG‐lowering effect of soybean 7S globulin, but not for CR domain. Metabolomics analysis reveals that oral administration of ER peptides obviously influences the metabolic profiling of serum bile acids (BAs), as well as significantly increased the fecal excretion of total BAs. Meanwhile, ER peptides supplementation reshapes the composition of gut microbiota and impacts the gut microbiota‐dependent biotransformation of BAs which indicate by a significantly increased secondary BAs concentration in fecal samples. These results highlight that TG‐lowering effects of ER peptides mainly stem from their modulation of BAs homeostasis.ConclusionOral administration of ER peptides can effectively lower serum TG level by regulating BAs metabolism. ER peptides have potential to be used as a candidate pharmaceutical for the intervention of dyslipidemia.
Photoperiod‐Dependent Effects of Grape‐Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats
Authors: Navarro‐Masip Èlia , Manocchio Francesca , Rodríguez Romina M. , Bravo Francisca Isabel , Torres‐Fuentes Cristina , Muguerza Begoña , Aragonès Gerard 
Published: July 2023

ScopeVariations in photoperiod patterns drive metabolic adaptations in mammals, involving important changes in body weight and adiposity. Moreover, (poly)phenols can help heterotrophs adopt metabolic adaptations to face the upcoming environmental conditions. Particularly, proanthocyanidins from grape‐seeds show photoperiod‐dependent effects on different metabolic parameters. The present study aims to explore whether grape‐seed proanthocyanidin extract (GSPE) consumption differently affects the expression of metabolic markers in WAT (subcutaneous and visceral depots) and BAT in a photoperiod‐dependent manner.Methods and resultsGSPE (25 mg kg−1 day−1) is orally administrated for 4 weeks to healthy rats exposed to three photoperiods (L6, L12, and L18). In WAT, GSPE consumption significantly upregulates the expression of lipolytic genes in all photoperiods, being accompanied by increased serum concentrations of glycerol and corticosterone only under the L6 photoperiod. Moreover, adiponectin mRNA levels are significantly upregulated in response to GSPE regardless of the photoperiod, whereas Tnfα and Il6 expression are only downregulated in L6 and L18 photoperiods but not in L12. In BAT, GSPE upregulates Pgc1α expression in all groups, whereas the expression of Pparα is only increased in L18.ConclusionsThe results indicate that GSPE modulates the expression of important metabolic markers of WAT and BAT in a photoperiod‐dependent manner.
Scientific Evidence for the Beneficial Effects of Dietary Blueberries on Gut Health: A Systematic Review
Authors: Della Lucia Ceres Mattos , Oliveira Livya Alves , Dias Kelly Aparecida , Pereira Stephanie Michelin Santana , da Conceição Aline Rosignoli , Anandh Babu Pon Velayutham 
Published: July 2023

AbstractEmerging evidence indicates the association between an unhealthy gut and chronic diseases. A healthy gut comprises an intact gut epithelium and balanced gut microbes. Diet is one of the critical factors that modulate gut health by positively or negatively affecting the intestinal barrier and gut microbes. Blueberries are an excellent source of health‐promoting bioactive components, and this systematic review is conducted to evaluate the effect of dietary blueberries on gut health. A literature search is conducted on PubMed/MEDLINE, Scopus, Web of Science, and Embase databases to review relevant studies published between 2011 and 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The Systematic Review Center for Laboratory Animal Experimentation Risk of Bias (SYRCLE‐RoB) tool is used for methodological quality assessments. Sixteen studies included from four countries are reviewed and the results are synthesized narratively. This data analysis indicates that blueberry supplementation improves gut health by improving intestinal morphology, reducing gut permeability, suppressing oxidative stress, ameliorating gut inflammation, and modulating the composition and function of gut microbes. However, there are significant knowledge gaps in this field. These findings indicate that further studies are needed to establish the beneficial effects of blueberries on gut health.
A comparative study of cognitive and behavioral profiles between sporadic and type 8 amyotrophic lateral sclerosis
Authors: de Alcântara Cássia , Cruzeiro Marcelo Maroco , França Marcondes Cavalcante , Alencar Mariana Asmar , Jaeger Antônio , de Araújo Caroline Martins , da Gama Natália Araújo Sundfeld , Camargos Sarah Teixeira , de Souza Leonardo Cruz 
Published: July 2023

AbstractIntroduction/AimsAmyotrophic lateral sclerosis (ALS) type 8 (ALS8) is caused by VAPB gene mutations. The differences between neuropsychological and behavioral profiles of patients with sporadic ALS (sALS) and those with ALS8 are unclear. We aimed to compare cognitive performance and behavioral aspects between sALS and ALS8 patients.MethodsOur study included 29 symptomatic ALS8 patients (17 men; median age 49 years), 20 sALS patients (12 men; median age 55 years), and 30 healthy controls (16 men; median age 50 years), matched for sex, age, and education. Participants underwent neuropsychological assessments focused on executive functions, visual memory, and facial emotion recognition. Behavioral and psychiatric symptoms were evaluated using the Hospital Anxiety and Depression Scale and the Cambridge Behavioral Inventory.ResultsClinical groups (sALS and ALS8) exhibited lower global cognitive efficiency and impaired cognitive flexibility, processing speed, and inhibitory control compared with controls. ALS8 and sALS showed similar performance in most executive tests, except for poorer verbal (lexical) fluency in those with sALS. Apathy, anxiety, and stereotypical behaviors were frequent in both clinical groups.DiscussionsALS and ALS8 patients demonstrated similar deficits in most cognitive domains and had comparable behavioral profiles. These findings should be considered in the care of patients.
DEM multi‐scale insights on the pre‐failure behavior of mature structured sands: Influence of bond type, amount, breakage pattern and heterogeneity
Authors: Reddy Nallala S. C. , He Huan , Senetakis Kostas 
Published: July 2023

AbstractA new approach in the calibration process of DEM samples of structured sand is presented. Micromechanical‐based experimental data are interpreted to develop a failure model and a range of input parameters in the DEM analyses are incorporated considering strong and a weak bonds in the simulated samples. Subsequently, the numerical samples correspond to analog mature structured soil/sandstone in terms of both compositional and textural maturity, and the study focused on the small‐to‐medium strain shear modulus and on providing multi‐scale insights of the simulated materials. The heterogeneity of the structured sand is incorporated based on Gaussian and Weibull distributions of the contact properties and four major parameters are examined including bonding amount/content, bonding strength, heterogeneity, and confining pressure. The numerical results showed, at the macroscopic level, agreement with respect to a number of element‐size experiments on sandstones which were re‐analyzed in the present work, in terms of stiffness—pressure relationship, stiffness reduction, and occurrence of the yield point associated with the initiation of bond breakage. It was shown that even though the bond strength and amount of bonds are important influencing factors on the macroscopic behavior of the structured sand, the incorporation of heterogeneity can significantly alter the interpretations of the microscopic involved mechanisms. This unveils that the implementation of “average” input parameters cannot capture well the contributing mechanisms which influence the deformation characteristics of structured soils and sandstones.
Electrohydrodynamic devices for ionic wind generation and airborne positive‐strand RNA viruses inactivation by nonthermal atmospheric plasma
Authors: Ruiz‐Trujillo Sonia , Vega‐Martínez Patricia , Esparza Iris , Usera Fernando , Sánchez‐Soriano Pilar , van Raaij Mark J. , Lantada Andrés Díaz 
Published: July 2023

AbstractAdaptable technologies capable of reducing contaminants in enclosed spaces are needed. The SARS‐CoV‐2 pandemic has highlighted the vulnerability of current systems forcing the adoption of extreme measures, causing a significant socioeconomic impact. Electrohydrodynamic devices are proposed as a competitive solution that allows obtaining a high degree of viral inactivation with a very low generation of chemical compounds and low power consumption, together with the production of an airflow, which makes its implementation in real environments easy. In this study, airborne positive‐strand RNA viruses are treated with nonthermal atmospheric plasma, achieving >3.4‐logR for HCoV‐229E and Bacteriophage‐MS2 and >2.4‐log SARS‐CoV‐2 at 4W, in a single pass, at O3 and NO2 concentrations ≤0.70 ppm. Electrical, fluid‐dynamic, and chemical characterization provides the design rules.
Finite‐time consensus for multi‐agent systems with directed dynamically changing topologies
Authors: Yang Haopeng , Li Zhi 
Published: July 2023

AbstractDue to the complexity of communication topologies, only a few works addressed the issues of finite‐time convergence for multi‐agent systems with directed switching topologies, whose analyses might be unclear and some assumptions seem to be a bit strong. In this study, finite‐time consensus of continuous‐time nonconvex‐constrained multi‐agent systems with directed dynamically changing topologies is addressed. Firstly, a distributed finite‐time consensus algorithm is introduced for continuous‐time multi‐agent systems. It is proved that agents will achieve consensus in finite time as long as the graphs have a joint spanning tree. Subsequently, we consider a constrained system whose control inputs are subjected to nonconvex sets and give a distributed nonsmooth finite‐time consensus algorithm. It is proved that consensus can be achieved in finite time while keeping agents' control inputs staying in the constraint sets. Furthermore, the distributed consensus algorithm is extended to the case with disturbances and the sufficient conditions are given to guarantee the achievement of consensus in finite time. Finally, numerical examples are included to demonstrate the effectiveness of theoretical conclusions.
Food waste interventions: Barriers on the way to sustainable food systems
Authors: Marouli Christina 
Published: July 2023

AbstractFood waste is an important concern of modern societies, and the European Union has committed to significantly reducing it, especially at the consumption level. This comparative case study analysis examines the barriers that actual interventions in the EU have experienced and explores the mechanisms and dynamics behind them using meta‐ethnographic approaches. Barriers relating to culture, politics and policies, administration, the economy, and the spatial and temporal organization of life were identified. It is concluded that food waste reduction is a bundle of interrelated practices, and it is best understood with a sociological approach that focuses on social practices rather than individuals. Concepts that emerged as important include risk and the spatial and temporal organization of everyday life. This study proposes that a focus on the nexus of food waste generation–risk–household dynamics–spatial/temporal organization of urban life, as well as the use of interventions (rather than individuals) as units of analysis are fruitful directions for future research and action.
Fear of COVID‐19, workplace phobia, workplace deviance and perceived organizational support: A moderated mediation model
Authors: Alagarsamy Subburaj , Mehrolia Sangeeta , Mathew Jain 
Published: July 2023

AbstractThis paper aims to test a moderated‐mediation model examining therelationships between Fear of COVID‐19, workplace phobia, work deviance behaviourand perceived organizational support among hotel employees. An online questionnaire was administered to collect data, to which 481 responded. Data was collected from full‐time frontline employees working in the Maldivian hospitality industry. The moderated‐mediation model explained 44% of the variance in workplace deviance behaviourscan be predicted bythe fear of COVID‐19, perceived organisational support and workplace phobia. The findingsshowthat perceived organizational support reduces the negative impact of COVID‐19 fear on workplace phobia and deviance. Results suggest that to reduce the negative effect of the pandemic, organisations should adopt support measures across different managerial levels at different scales rather than providing one‐size‐fits‐all solutions.
Synthesis of CsPbBr3 in Micro Total Reaction System: Fast Operation Space Mapping and Subsecond Growth Process Monitoring
Authors: Geng Yuhao , Hu Haoyang , Jia Yongqi , Huang Xintong , Yang Tian , Liang Runzhe , Chen Zhuo , Yuan Zhihong , Xu Jianhong 
Published: July 2023

AbstractLead halide perovskite nanocrystals (LHP NCs) have the characteristics of fast reaction kinetics and crystal instability due to the intrinsically highly ionic bonding between the respective ions, which bring challenges for revealing the growth kinetics and practical applications. Compared with conventional batch synthesis methods, the single‐function microreactor can achieve precise and stable control of the NCs synthesis process, but it still has the shortcoming of not being able to obtain information about the growth process. In this study, a micro Total Reaction System (μTRS) with remote control, online detection, and rapid data analysis functions is designed. μTRS can sample the photoluminescence information of CsPbBr3 NCs growth in ligand‐assisted reprecipitation method. CsPbBr3 NCs with an emission range of 435–492 nm are successfully detected, which breaks the record of the smallest size of CsPbBr3 NCs synthesized directly from precursors. The real‐time feature of μTRS enables the construction of an automated close‐loop synthesis system. Besides, the rapid acquisition and timely processing of product information enable the rapid mapping of the operation space for CsPbBr3 NCs preparation, which provides a reliable and learnable data set for designing a fully autonomous microreaction system capable of synthesizing NCs.
Flexo‐Pyrophotronic Effect Modulated Giant Near Infrared Photoresponse from VO2‐Based Heterojunction for Optical Communication
Authors: Kumar Mohit , Kim Dukhwan , Seo Hyungtak 
Published: July 2023

AbstractThe flexoelectric phenomenon, which occurs when materials undergo mechanical deformation and cause strain gradients and a related spontaneous electric polarization field, can result in wide variety of energy‐ and cost‐saving mechano‐opto‐electronics, such as night vision, communication, and security. However, accurate sensing of weak intensities under self‐powered conditions with stable photocurrent and rapid temporal response remains essential despite the challenges related to having suitable band alignment and high junction quality. Taking use of the flexoelectric phenomena, it is shown that a centrosymmetric VO2‐based heterojunction exhibits a self‐powered (i.e., 0 V), infrared (λ = 940 nm) photoresponse. Specifically, the device shows giant current modulation (103%), good responsivity of >2.4 mA W−1, reasonable specific detectivity of ≈1010 Jones, and a fast response speed of 0.5 ms, even at the nanoscale modulation. Through manipulation of the applied inhomogeneous force, the sensitivity of the infrared response is enhanced (> 640%). Ultrafast night optical communication like Morse code distress (SOS) signal sensing and high‐performing obstacle sensors with potential impact alarms are created as proof‐of‐concept applications. These findings validate the potential of emerging mechanoelectrical coupling for a wide variety of novel applications, including mechanoptical switches, photovoltaics, sensors, and autonomous vehicles, which require tunable optoelectronic performance.
ACE2 PET in healthy and diseased conditions
Authors: Li Rou , Xu Aijing , Cheng Chao , Chen Jian , Wang Mingxin , Luo Xiu , Liang Siyu , Hou Wenli , Cui Bin , Feng Yu , Zuo Changjing , Li Xiao 
Published: July 2023

AbstractAngiotensin converting enzyme 2 (ACE2) played a critical role in regulating renin‐angiotensin‐aldosterone system (RAAS). In this research, 68Ga‐cyc‐DX600 was synthesized as PET tracer of ACE2 imaging. ACE2 positron emission tomography/magnetic resonance (PET/MR) was preliminary administered on twelve healthy volunteers, and the images were normalized and registered to establish the standard model of ACE2 PET. In diseased conditions, 68Ga‐cyc‐DX600 PET and 18F‐FDG PET were compared for COVID‐19 (one in acute phase and three in post‐COVID), anemia (n = 1) and malignancies (n = 2) to evaluate the diagnostic efficiency. 68Ga‐cyc‐DX600 PET was of a definite ACE2 dependence. For the tracer uptake of ACE2 PET/MR of female and male, differences existed in salivary glands, upper respiratory tract and kidneys, meanwhile, age, and body mass index (BMI) were also the confounding factors. RAAS‐related tissue and organs were of the relatively higher tracer uptake, such as SUVmean of cardiac chamber (3.786 ± 1.495), liver (5.342 ± 2.267), spleen (4.465 ± 2.508), and kidney (4.906 ± 1.619 for female and 8.431 ± 5.179 for male). For COVID‐19, ACE2 PET revealed ACE2 fluctuations, particularly in the susceptible organs, including liver, spleen and testis. In the case of anemia, the activated local RAS in the bone marrow was of diffuse high tracer uptake. ACE2 PET of malignancies added supplementary information to FDG PET. 68Ga‐cyc‐DX600‐based ACE2 PET models were established for visually monitoring of whole‐body ACE2 expression. The feasibility of ACE2 PET in supervising disease was primarily proved in COVID‐19, anemia and malignancies as providing a comprehensive view on the disease process and functional recovery.
An Integrated Approach for Hand Motion Segmentation and Robot Skills Representation
Authors: Lu Shuang , Berger Julia , Schilp Johannes 
Published: July 2023

AbstractIn this work, an approach for robot skill learning from voice command and hand movement sequences is proposed. The motion is recorded by a 3D camera. The proposed framework consists of three elements. Firstly, a hand detector is applied on each frame to extract key points, which are represented by 21 landmarks. The trajectories of index finger tip are then taken as hand motion for further processing. Secondly, the trajectories are divided into five segments by voice command and finger moving velocities. These five segments are: reach, grasp, move, position and release, which are considered as skills in this work. The required voice commands are grasp and release, as they have short duration and can be viewed as discrete events. In the end, dynamic movement primitives are learned to represent reach, move and position. In order to show the result of the approach, a human demonstration of a pick-and-place task is recorded and evaluated.
Empirically Adapted Model for the Handling of Variable Geometries with Vacuum-Based Granulate Grippers
Authors: Wacker Christian , Dierks Niklas , Joana Illgen , Kwade Arno , Dröder Klaus 
Published: July 2023

AbstractCurrent industrial trends show an increasing demand for individualized products, which require highly flexible yet automated production systems. Universal handling systems offer an efficient solution for the flexible and safe handling of differing component geometries and shapes. An innovative gripper for form-flexible handling combining vacuum systems with the flexibility of granulate grippers was established in previous research and has continued to prove its flexibility by gripping wide varieties of object geometries. The current challenge of modelling and predicting gripping forces for this new gripper is addressed in this research. Multiple object geometries are selected and examined, with the parameters affecting the air permeability being the most important influence for the gripping forces. Along with an overview of influencing factors and parameters, a framework for a linear model enabling the prediction of gripping forces for different object shapes is developed. The basis for automated prediction of gripping strengths for different types of objects is established with this research and could be adapted with other, non-analytical models such as machine learning in the future.