bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emersion and recovery alter oxygen consumption, ammonia and urea excretion, and oxidative stress parameters, but not diffusive water exchange or transepithelial potential in the green crab (Carcinus maenas)
Authors: Sadauskas-Henrique Helen , Johannsson Ora E. , Po Beverly H. K. , Val Adalberto L. , Wood Chris M. 
Published: May 2023

ABSTRACT
The green crab (Carcinus maenas) is an inshore species affected by intertidal zonation patterns, facing periods of emersion during low tide and submersion during high tide. During these periods of air and subsequent water exposure, these species can face physiological challenges. We examined changes in O2 consumption rate (ṀO2), and ammonia and urea excretion rates over sequential 14 h periods in seawater (32 ppt, control), in air and during recovery in seawater after air exposure (13°C throughout). At the end of each exposure, the anterior (5th) and posterior (8th) gills and the hepatopancreas were removed for measurements of oxidative stress parameters (TBARs and catalase in the gills and hepatopancreas, and protein carbonyls in the gills). ṀO2 remained unchanged during air exposure, but increased greatly (3.4-fold above control levels) during the recovery period. Ammonia and urea net fluxes were reduced by 98% during air exposure, but rebounded during recovery to &gt;2-fold the control rates. Exchangeable water pools, rate constants of diffusive water exchange, unidirectional diffusive water flux rates (using tritiated water) and transepithelial potential were also measured during control and recovery treatments, but exhibited no significant changes. Damage to proteins was not observed in either gill. However, lipid damage occurred in the anterior (respiratory) gill after the air exposure but not in the posterior (ionoregulatory) gill or hepatopancreas. Catalase activity also decreased significantly in recovery relative to levels during air exposure in both the anterior gill and hepatopancreas, but not in the posterior gill. The crabs did not modify water metabolism or permeability. We conclude that ṀO2 was maintained but not enhanced during air exposure, while ammonia and urea-N excretion were impaired. As a result, all of these parameters increase greatly during re-immersion recovery, and oxidative stress also occurs. Clearly, emersion is not without physiological costs.
Effect of clinical pharmacists participating in nutritional therapy for patients with acute cerebral infarction complicated with dysphagia
Authors: Wu Lixin , Hou Haiyan 
Published: May 2023

Objective: To explore the effect of clinical pharmacists participating in nutritional therapy for patients with acute cerebral infarction (ACI) complicated with dysphagia.
Methods: This is a Clinical comparative study. A total of 82 patients with ACI complicated with dysphagia treated in Baoding No.1 Central Hospital from May 2021 to February 2022 were included as subjects. They were divided into control group (n= 40, without clinical pharmacists) and experimental group (n= 42, with clinical pharmacists) using a random number table. The effect of nutritional therapy and the incidence of adverse reactions were compared between the two groups.
Results: In the experimental group, PALB and ALB were both higher than those in the control group on the seven and 14-day after treatment (p< 0.05), while HB was higher than that in the control group only on the 14-day after treatment (p< 0.05). After treatment for 14-day, MAMC and TSF in the experimental group were higher than those in the control group (p< 0.05), while NIHSS score was lower than that in the control group (p< 0.05). The incidence of adverse events in the experimental group was lower than that in the control group (p< 0.05).
Conclusion: Pharmaceutical intervention in nutritional therapy for patients with ACI complicated with dysphagia has positive significance in further improving the nutritional status and nutritional indexes, enhancing the efficacy of drug treatment and reducing the risk of adverse events, and is worthy of promotion.
doi: https://doi.org/10.12669/pjms.39.4.7121
How to cite this: Wu L, Hou H. Effect of clinical pharmacists participating in nutritional therapy for patients with acute cerebral infarction complicated with dysphagia. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.7121
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Probiotics and gut-skin axis - new look on factors affecting skin condition
Authors: Małolepsza Aleksandra , Dembowski Tomasz 
Published: May 2023

Introduction and purpose
The human gut microbiota consists of trillions of microscopic organisms, mostly bacterias. They play a significant role in nutrient metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation and protection against pathogens. Many factors can influence the composition of the intestinal microbiota, for example antibiotics, diet or stress. These factors may lead to dysbiosis which causes activation of neurotransmitters. It can results in the entry of metabolites to the blood stream, systemic immune dysregulation and alteration of skin microbiota. The aim of the study was to review the literature and determine the effects of intestinal microbiota and probiotics in selected skin diseases and what is new - skin aging process.
State of knowledge
We analyzed numerous studies which indicate that disturbed gut microbiota can be related to some chronic diseases, including skin disorders such as atopic dermatitis, acne vulgaris, psoriasis and rosacea. Additionally, it has been proven that bacterial dysbiosis can intensify the skin aging proces. In order to reproduce normal gut microbiota probiotics are used. Despite the fact that there are only a few studies showing the unequivocal effect of probiotics on skin diseases, their results seem to be encouraging.
Conclusions
Proper composition of the intestinal microbiome determines the homeostasis of the human body. Disturbance of the gut microbiome play a significant role not only in development and aggravation of many skin diseases, but also have an impact on the skin aging. Despite quite a lot number of studies assessing the impact of microbiota on certain skin disorders, there is still a need to evaluate impact of probiotics. Researches indicate that they can be used as a helpful therapeutic tool. Taking this into account, it is worth considering it in the treatment process.
Geographic Virtual Pooling of Hospital Resources: Data-Driven Trade-off Between Waiting and Traveling
Authors: Jiang Yangzi , Abouee Mehrizi Hossein , Van Mieghem Jan A. 
Published: May 2023

Problem definition: Patient-level data from 72 magnetic resonance imaging (MRI) hospitals in Ontario, Canada from 2013 to 2017 show that over 60% of patients exceeded their wait time targets. We conduct a data-driven analysis to quantify the reduction in the patient fraction exceeding (FET) target for MRI services through geographic virtual resource-sharing while limiting incremental driving time. We present a data-driven method to solve the geographic pooling problem of partitioning 72 hospitals with heterogeneous patients with different wait time targets located in a two-dimensional region into a set of clusters. Methodology/results: We propose an “augmented-priority rule,” which is a sequencing rule that balances the patient’s initial priority class and the number of days until her wait time target. We then use neural networks to predict patient arrival and service times. We combine this predicted information and the sequencing rule to implement “advance scheduling,” which informs the patient of her treatment day and location when requesting an MRI scan. We then optimize the number of geographic resource pools among the 72 hospitals using genetic algorithms. Our resource-pooling model lowers the FET from 66% to 36% while constraining the average incremental travel time below three hours. In addition, our model shows that only 10 additional scanners are needed to achieve 10% FET, whereas 50 additional scanners would be needed without resource sharing. Over 70% of the hospitals are not worse off financially. Each individual hospital, measured over at least two weeks, achieves a higher machine utilization and a lower FET. Managerial implications: Our paper provides a practical, data-driven geographical resource-sharing model that hospitals can readily implement. Our method achieves a near-optimal solution with low computational complexity. Using smart data-driven scheduling, a little extra capacity placed at the right location is all we need to achieve the desired FET under geographic resource-sharing. Funding: This paper is supported by the following grant: Canadian Institutes of Health Research (CIHR) [Grant CIHR-950-231935]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1225 .
How Should We Score Athletes and Candidates: Geometric Scoring Rules
Authors: Kondratev Aleksei Y. , Ianovski Egor , Nesterov Alexander S. 
Published: May 2023

Scoring in Multi-Event Tournaments How much is a first place worth? Is the athlete who came first once and third twice better than the athlete who came second three times? Different sports value these positions differently: (60, 54, 48) in IBU biathlon, (25, 18, 15) in F1 racing, (8, 7, 6) in Diamond League athletics. Are these choices based on anything? Is there even a rational way to choose a scoring vector of arbitrary length to rank any number of athletes? In “How should we score athletes and candidates: Geometric scoring rules,” authors A.Y. Kondratev, E. Ianovski, and A.S. Nesterov investigate two approaches to how the problem of choosing a scoring vector for a tournament can be reduced to the choice of a single parameter: an axiomatic approach based on eliminating spoilers and an optimization approach based on maximizing the expected quality of the winner. Intriguingly, the vectors generated by the second approach are uncannily similar to those used in real sporting events.
Distributed optical strain sensing measurements down to cryogenic temperatures
Authors: Kandemir K. , Guinchard M. , Crouvizier M. , Sacristan O. , Mugnier S. 
Published: May 2023

Rayleigh backscattering (RBS)-based distributed fiber sensors technology is becoming more and more crucial in various fields such as aerospace and defense, automotive, civil, and geotechnical. This technology is measuring the naturally occurring Rayleigh backscatter level in the optical fiber core; thus, any standard single-mode telecom optical fiber can be used. The application of distributed optical fiber strain sensing in the harsh environments of the European Organization for Nuclear Research required several mechanical tests to study the accuracy of strain sensing in cryogenic conditions. This study compares the performance of a RBS-based distributed optical fiber strain sensing down to cryogenic temperatures (4.2 K) with previously validated instrumentations such as electrical strain gauges and fiber Bragg grating technologies.
Resource-efficient quantum key distribution with integrated silicon photonics
Authors: Wei Kejin , Hu Xiao , Du Yongqiang , Hua Xin , Zhao Zhengeng , Chen Ye , Huang Chunfeng , Xiao Xi 
Published: May 2023

Integrated photonics provides a promising platform for quantum key distribution (QKD) system in terms of miniaturization, robustness, and scalability. Tremendous QKD works based on integrated photonics have been reported. Nonetheless, most current chip-based QKD implementations require additional off-chip hardware to demodulate quantum states or perform auxiliary tasks such as time synchronization and polarization basis tracking. Here, we report a demonstration of resource-efficient chip-based BB84 QKD with a silicon-based encoder and a decoder. In our scheme, the time synchronization and polarization compensation are implemented relying on the preparation and measurement of the quantum states generated by on-chip devices; thus, we need no additional hardware. The experimental tests show that our scheme is highly stable with a low intrinsic quantum bit error rate of 0.50%±0.02% in a 6 h continuous run. Furthermore, over a commercial fiber channel up to 150 km, the system enables the realization of secure key distribution at a rate of 866 bit/s. Our demonstration paves the way for a low-cost, wafer-scale manufactured QKD system.
Patient engagement in decision making and associated factors among outpatients with selected non-communicable chronic diseases in public hospitals of West Shoa, Ethiopia
Authors: Emana Desalegn , Kitaba Mulu , Girma Taka , lekassa Shalama , Regea Firaol , Dina Hunduma , Mulgeta Segni 
Published: May 2023

Background
Despite the importance of patient engagement in health care decision-making in the care of patients with chronic diseases, there is limited information about it and the factors affecting it in Ethiopia and in the Public Hospitals of West Shoa in particular. Thus, this study was designed to assess the engagement of patients with selected chronic non-communicable diseases in health care decision-making and associated factors in public hospitals of West Shoa Zone, Oromia, Ethiopia.

Methods
We used an institution -based cross-sectional study design. We used systematic sampling for the selection of study participants from June 7–July 26, 2020. Standardized, pretested, and structured Patient Activation Measure was used to measure patient engagement in healthcare decision-making. We did descriptive analysis to determine the magnitude of patient engagement in health care decision-making. Multivariate logistic regression analysis was used to determine factors associated with patients’ engagement in the health care decision-making process. Adjusted odds ratio with a 95% confidence interval was calculated to measure the strength of association. We declared statistical significance at p<0.05. we presented the results in tables and graphs.

Results
406 patients with chronic diseases took part in the study, yielding a response rate of 96.2%. Less than a fifth [19.5% (95% CI: 15.5, 23.6)] of participants in the study area had a high engagement in their health care decision-making. Educational level (college or above) [AOR = 5.2, 95% CI (1.76–15.46)], duration of diagnosis >5 years [AOR = 1.8, 95% CI (1.03–3.2)], health literacy [AOR = 1.15, 95% CI (1.06–1.24)], autonomy preference in decision making [AOR = 1.35, 95% CI (1.03–1.96)] were factors significantly associated with participants’ engagement in health care decision making among patients with chronic diseases.

Conclusion
A high number of respondents had a low engagement in their health care decision-making. Preference for autonomy in decision making, educational level, health literacy, duration of diagnosis with the disease were factors associated with patient engagement in health care decision making among patients with chronic diseases in the study area. Thus, patients should be empowered to be involved in decision making to increase their engagement in the care.
Prevalence of mental health problems among children with long COVID: A systematic review and meta-analysis
Authors: Mat Hassan Nurulhuda , Salim Hani Syahida , Amaran Safiya , Yunus Nurul Izza , Yusof Nurul Azreen , Daud Norwati , Fry Deborah 
Published: May 2023

Introduction
The number of children with mental health problems has more than doubled since the COVID-19 pandemic. However, the effect of long Covid on children’s mental health is still debatable. Recognising long Covid as a risk factor for mental health problems in children will increase awareness and screening for mental health problems following COVID-19 infection, resulting in earlier intervention and lower morbidity. Therefore, this study aimed to determine the proportion of mental health problems post-COVID-19 infection in children and adolescents, and to compare them with the population with no previous COVID-19 infection.

Methodology
A systematic search was done in seven databases using pre-defined search terms. Cross-sectional, cohort and interventional studies reporting the proportion of mental health problems among children with long COVID in the English language from 2019 to May 2022 were included. Selection of papers, extraction of data and quality assessment were done independently by two reviewers. Studies with satisfactory quality were included in meta-analysis using R and Revman software programmes.

Results
The initial search retrieved 1848 studies. After screening, 13 studies were included in the quality assessments. Meta-analysis showed children who had previous COVID-19 infection had more than two times higher odds of having anxiety or depression, and 14% higher odds of having appetite problems, compared to children with no previous infection. The pooled prevalence of mental health problems among the population were as follows; anxiety: 9%(95% CI:1, 23), depression: 15%(95% CI:0.4, 47), concentration problems: 6%(95% CI: 3, 11), sleep problems: 9%(95% CI:5, 13), mood swings: 13% (95%CI:5, 23) and appetite loss: 5%(95% CI:1, 13). However, studies were heterogenous and lack data from low- and middle-income countries.

Conclusion
Anxiety, depression and appetite problems were significantly increased among post-COVID-19 infected children, compared to those without a previous infection, which may be attributed to long COVID. The findings underscore the importance of screening and early intervention of children post-COVID-19 infection at one month and between three to four months.
Acid-base and metabolic parameters and cerebral oxygenation during the immediate transition after birth—A two-center observational study
Authors: Mattersberger Christian , Baik-Schneditz Nariae , Schwaberger Bernhard , Schmölzer Georg M. , Mileder Lukas , Urlesberger Berndt , Pichler Gerhard 
Published: May 2023

Objective
The association between blood glucose level and cerebral oxygenation (cerebral regional oxygen saturation [crSO2] and cerebral fractional tissue oxygen extraction [FTOE]) in neonates has already been described. Aim of the present study was to investigate if acid-base and other metabolic parameters have an impact on cerebral oxygenation immediately after birth in preterm and term neonates.

Study design
Post-hoc analyses of secondary outcome parameters of two prospective observational studies were performed. Preterm and term neonates born by caesarean section were included, in whom i) cerebral near-infrared spectroscopy (NIRS) measurements were performed during the first 15 minutes after birth and ii) a capillary blood gas analysis was performed between 10 and 20 minutes after birth. Vital signs were routinely monitored with pulse oximetry (arterial oxygen saturation [SpO2] and heart rate [HR]). Correlation analyses were performed to investigate potential associations between acid-base and metabolic parameters (lactate [LAC], pH-value [pH], base-excess [BE] and bicarbonate [HCO3]) from capillary blood and NIRS-derived crSO2 and FTOE at 15 minutes after birth.

Results
One-hundred-fifty-seven neonates, 42 preterm neonates (median gestational age [IQR] 34.0 weeks [3.3], median birth weight 1845g [592]) and 115 term neonates (median gestational age [IQR] 38.9 weeks [1.0], median birth weight 3230g [570]) were included in the study. Median crSO2 [IQR] values at 15 minutes after birth were 82% [16] in preterm neonates and 83% [12] in term neonates. Median FTOE [IQR] values at 15 minutes after birth were 0.13 [0.15] in preterm neonates and 0.14 [0.14] in term neonates. In preterm neonates, higher LAC and lower pH and BE were associated with lower crSO2 and higher FTOE. In term neonates, higher HCO3 was associated with higher FTOE.

Conclusion
There were significant associations between several acid-base and metabolic parameters and cerebral oxygenation in preterm neonates, while in term neonates only HCO3 correlated positively with FTOE.
Views from women and maternity care professionals on routine discussion of previous trauma in the perinatal period: A qualitative evidence synthesis
Authors: Cull Joanne , Thomson Gill , Downe Soo , Fine Michelle , Topalidou Anastasia 
Published: May 2023

Background
Over a third of pregnant women (around 250,000) each year in the United Kingdom have experienced trauma such as domestic abuse, childhood trauma or sexual assault. These experiences can have a long-term impact on women’s mental and physical health. This global qualitative evidence synthesis explores the views of women and maternity care professionals on routine discussion of previous trauma in the perinatal period.

Methods
Systematic database searches (MEDLINE, EMBASE, CINAHL Plus, APA PsycINFO and Global Index Medicus) were conducted in July 2021 and updated in April 2022. The quality of each study was assessed using the Critical Appraisal Skills Programme. We thematically synthesised the data and assessed confidence in findings using GRADE-CERQual.

Results
We included 25 papers, from five countries, published between 2001 and 2022. All the studies were conducted in high-income countries; therefore findings cannot be applied to low- or middle-income countries. Confidence in most of the review findings was moderate or high. The findings are presented in six themes. These themes described how women and clinicians felt trauma discussions were valuable and worthwhile, provided there was adequate time and appropriate referral pathways. However, women often found being asked about previous trauma to be unexpected and intrusive, and women with limited English faced additional challenges. Many pregnant women were unaware of the extent of the trauma they have suffered, or its impact on their lives. Before disclosing trauma, women needed to have a trusting relationship with a clinician; even so, some women chose not to share their histories. Hearing trauma disclosures could be distressing for clinicians.

Conclusion
Discussions of previous trauma should be undertaken when women want to have the discussion, when there is time to understand and respond to the needs and concerns of each individual, and when there are effective resources available for follow up if needed. Continuity of carer should be considered a key feature of routine trauma discussion, as many women will not disclose their histories to a stranger. All women should be provided with information about the impact of trauma and how to independently access support in the event of non-disclosures. Care providers need support to carry out these discussions.