bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese herbal medicine combined with western medicine for the treatment of type 2 diabetes mellitus with hyperuricemia: A systematic review and meta-analysis
Authors: Liu Hongyan , Peng Sihan , Yuan Haipo , He Yuchi , Tang Jiao , Zhang Xiyu 
Published: January 2023

Background: Chinese herbal medicine (CHM) has the advantage of being safe and effective and has been widely used in clinical practice for the treatment of type 2 diabetes mellitus (T2DM) with hyperuricemia (HUA), but its overall efficacy and safety remain unclear. This study aimed to evaluate the efficacy and safety of CHM for the treatment of T2DM with HUA based on randomized controlled trials (RCTs) to provide clinical evidence.Methods: The protocol evaluated in this study is registered with PROSPERO (CRD42022351519). As of November 2022, eight databases were searched, and RCTs of CHM for the treatment of T2DM with HUA were included. Outcome indicators observed included fasting blood glucose (FBG), 2-h postprandial glucose (2hPG), glycated hemoglobin (HbA1c), uric acid (UA), triglycerides (TG), total cholesterol (TC), overall effectiveness, and adverse events. Utilizing Review Manager 5.4, Stata V14.0, and GRADEpro, the included studies were evaluated, and the quality of the evidence was determined.Results: 18 RCTs covering 1,311 patients were included in this study. The results of the study demonstrated that the combination of CHM and western medicine (WM) was more effective in treating patients with T2DM with HUA than WM alone, with significant improvements in FBG (weighted mean differences (WMD) = −0.60.95% confidence interval (CI) [−0.81, −0.40], p &lt; 0.00001), 2hPG (WMD = −1.12.95% CI [−1.64, −0.60], p &lt; 0.0001), HbA1c (WMD = −0.80.95% CI [−1.04, −0.56], p &lt; 0.00001), UA (WMD = −53.47.95% CI [−67.45, −39.48], p &lt; 0.00001), TG (WMD = −0.56.95% CI [−0.74, −0.38], p &lt; 0.00001), TC (WMD = −0.49.95% CI [−0.65, −0.33], p &lt; 0.00001), and overall effective rate (risk ratio (RR) = 1.29.95%CI [1.13, 1.48], p = 0.0002). The quality of evidence for all outcomes was low.Conclusion: Compared with WM alone, the combination of CHM and WM was more effective in treating patients with T2DM with HUA, with significant improvements in glucose metabolism, uric acid, and lipids. However, further evaluation by high−quality RCT results is needed due to the low quality and high heterogeneity of the evidence.Systematic Review Registration: [https://systematicreview.gov/], identifier [CRD42022351519].
RADFNet: An infrared and visible image fusion framework based on distributed network
Authors: Feng Siling , Wu Can , Lin Cong , Huang Mengxing 
Published: January 2023

IntroductionThe fusion of infrared and visible images can improve image quality and eliminate the impact of changes in the agricultural working environment on the information perception of intelligent agricultural systems.MethodsIn this paper, a distributed fusion architecture for infrared and visible image fusion is proposed, termed RADFNet, based on residual CNN (RDCNN), edge attention, and multiscale channel attention. The RDCNN-based network realizes image fusion through three channels. It employs a distributed fusion framework to make the most of the fusion output of the previous step. Two channels utilize residual modules with multiscale channel attention to extract the features from infrared and visible images, which are used for fusion in the other channel. Afterward, the extracted features and the fusion results from the previous step are fed to the fusion channel, which can reduce the loss in the target information from the infrared image and the texture information from the visible image. To improve the feature learning effect of the module and information quality in the fused image, we design two loss functions, namely, pixel strength with texture loss and structure similarity with texture loss.Results and discussionExtensive experimental results on public datasets demonstrate that our model has superior performance in improving the fusion quality and has achieved comparable results over the state-of-the-art image fusion algorithms in terms of visual effect and quantitative metrics.
The influence of physical exercise on college students’ life satisfaction: The chain mediating role of self-control and psychological distress
Authors: Zhou Guang-Yu , Yang Bin , Li Hao , Feng Quan-Sheng , Chen Wan-Yi 
Published: January 2023

ObjectiveTo explore the relationship between physical exercise and life satisfaction among college students and test the dual mediating role of self-control and psychological distress between them.MethodsA sample of 526 Chinese college students completed questionnaires regarding physical exercise, life satisfaction, self-control and psychological distress, of which 38.4% were boys.ResultsPath analyzes indicated that physical exercise was positively correlated with life satisfaction, and this link could be mediated by self-control and psychological distress.ConclusionThe present study identifies the potential underlying mechanism by which physical exercise is associated with the life satisfaction of college students, which has important implications for theory and prevention.
Joint effects of individual socioeconomic status and residential neighborhood context on vaginal microbiome composition
Authors: Dixon Meredith , Dunlop Anne L. , Corwin Elizabeth J. , Kramer Michael R. 
Published: January 2023

IntroductionThe vaginal microbiome is a dynamic ecosystem that is important for women's health. Its composition has been associated with risk for menopausal symptoms, sexually transmitted infections, gynecologic cancer, and preterm birth. Conventional risk factors for a vaginal microbiome linked with these adverse health outcomes include sexual behaviors, hygiene practices, individual social factors, and stress levels. However, there has been limited research on socio-contextual determinants, and whether neighborhood context modifies the association with individual socioeconomic factors.MethodsSocioeconomically diverse pregnant African American women in Atlanta, Georgia (n = 439) provided residential addresses and first trimester vaginal swab samples, which underwent sequencing, taxonomic classification, and assignment into mutually exclusive CST (community state types) via hierarchical clustering. Linear probability models were used to estimate prevalence differences (PD) for the associations of neighborhood factors with vaginal microbiome CST and to evaluate for additive interaction with maternal level of education, health insurance type, and recruitment hospital.ResultsFactors such as higher (vs. lower) maternal education, private (vs. public) insurance, and private (vs. public) hospital were associated with higher prevalence of Lactobacillus-dominant vaginal microbiome CSTs typically associated with better health outcomes. When considering the joint effects of these individual socioeconomic status and residential neighborhood factors on vaginal microbiome CST, most combinations showed a greater than additive effect among the doubly exposed; however, in the case of local income homogeneity and local racial homogeneity, there was evidence of a crossover effect between those with less-advantaged individual socioeconomic status and those with more-advantaged individual socioeconomic status. Compared to women at the public hospital who lived in economically diverse neighborhoods, women at the private hospital who lived in economically diverse neighborhoods had a 21.9% higher prevalence of Lactobacillus-dominant CSTs, while women at the private hospital who lived in less economically diverse neighborhoods (the doubly exposed) had only an 11.7% higher prevalence of Lactobacillus-dominant CSTs, showing a crossover effect (interaction term p-value = 0.004).DiscussionIn this study, aspects of residential neighborhood context were experienced differently by women on the basis of their individual resources, and the joint effects of these exposures on vaginal microbiome CST showed a departure from simple additivity for some factors.
Risk of peripheral facial palsy following parenteral inactivated influenza vaccination in the elderly Chinese population
Authors: Yang Tianchi , Ma Rui , Ye Lixia , Mei Qiuhong , Wang Jianmei , Feng Yueyi , Zhou Shaoying , Pan Xingqiang , Hu Danbiao , Zhang Dandan 
Published: January 2023

BackgroundConcern about the risk of peripheral facial palsy (PFP) following vaccination is one reason for hesitancy in influenza vaccination. However, the association between the flu vaccine and PFP is still controversial, and further evidence is urgently needed.MethodsThis self-controlled case series study evaluated PFP risk following inactivated influenza vaccine in the elderly using a large linked database in Ningbo, China. Relative incidence ratios (RIRs) and 95% confidence intervals (CIs) estimated using conditional Poisson regression were utilized to determine whether the risk of PFP was increased after vaccination.ResultsThis study included 467 episodes, which occurred in 244 females and 220 males. One hundred twenty-four episodes happened within 1–91 days after vaccination, accounting for 26.7%. The adjusted RIRs within 1–30 days, 31–60 days, 61–91 days, and 1–91 days after influenza vaccination were 0.95 (95% CI 0.69–1.30), 1.08 (95% CI 0.78–1.49), 1.01 (95% CI 0.70–1.45), and 1.00 (95% CI 0.81–1.24), respectively. Similar results were found in subgroup analyses and sensitivity analyses.ConclusionsInfluenza vaccination does not increase PFP risk in the elderly population. This finding provides evidence to overcome concerns about facial paralysis after influenza vaccination.
Development and evaluation of an intervention to promote the use of eyeglasses among Romani families in Bulgaria
Authors: Kodjebacheva Gergana Damianova , Hristova Slavka Grigorova , Savov Ventsislav 
Published: January 2023

ObjectiveUncorrected refractive error (i.e., lack of eyeglasses for the treatment of refractive error) is one of the leading causes of visual impairment in Eastern Europe. Limited information is available on how to promote the use of eyeglasses among Romani families in Bulgaria. In step 1, the objective was to obtain suggestions by Romani mothers on how to promote the use of eyeglasses among children. In step 2, the objective was to evaluate an intervention to promote the use of eyeglasses based on suggestions received during step 1.MethodsDuring step 1, 5 focus groups with Romani mothers took place in one neighborhood in Bulgaria. During step 2, the intervention used a one-group pre-test, post-test design. Families received eye examinations. Those who needed eyeglasses chose attractive eyeglasses. Parents received education on how to encourage their children to wear eyeglasses.ResultsDuring step 1, 54 mothers participated. Mothers suggested that the whole family should receive eye examinations and eyeglasses. During step 2, of 33 family members, 14 did not have refractive errors and 19 did. Of the 19 family members with refractive error, none had eyeglasses at pre-test. Approximately 6 months following the end of the intervention, 11 of the 19 family members (57.9%) wore eyeglasses and the remaining 8 (42.1%) did not.ConclusionRomani family members needed eyeglasses but did not have any at pre-test of the intervention. Future interventions that offer education on the importance of eye examinations may increase receipt of eye examinations and adherence to wearing eyeglasses.
Clinical outcomes of percutaneous transhepatic biliary drainage at different Couinaud's hepatic entry segments for treating obstructive jaundice
Authors: Hsu Ya-Chun , Lee Hsing-Yu , Chang Chia-Ming , Lin Chia-Ying , Liu Yi-Sheng , Huang Han-Sheng 
Published: January 2023

IntroductionPercutaneous transhepatic biliary drainage (PTBD) is a common procedure for biliary obstructive jaundice caused by biliary tract obstruction. In clinical practice, PTBD can be carried out at right- or left-sided approach. However, different hepatic entry site may affect success rates and complications. Couinaud classification of liver anatomy further divides the liver into functionally independent segments (segment 2/3, segment 5/6, and segment 7/8). Therefore, this study aimed to elucidate whether different Couinaud hepatic segments as PTBD entry site are associated with high PTBD success and low complications.MethodsA total of 617 patients who underwent PTBD were retrospectively reviewed. Univariate and multivariate logistic regression analyses were performed to identify entry segments associated with PTBD success, bilirubin reduction, and complications.ResultsWith higher hepatic segment of PTBD entry site (segment 2/3, 5/6, and 7/8), the trend of PTBD success rate (82.0%, 71.7% and 60.7%; P&lt;0.001) and bilirubin reduction (93.2%, 89.5%, and 82.0%; P=0.012) decreased. Furthermore, PTBD entry at segment 7/8 (42.6%) had highest complication rate than segment 5/6 (6.4%) and 2/3 (9.4%). Univariate and multivariate logistic regression analyses showed that PTBD entry segment was an independent factor associated with PTBD success, bilirubin reduction, and complications. Compared to segment 7/8, segment 2/3 and 5/6 had higher odds of PTBD success (aOR=2.699 and aOR=1.454, respectively) and bilirubin reduction (aOR=3.472 and aOR=2.361, respectively) and associated with lower risk of complications (aOR=0.143 and aOR=0.098, respectively). No independent risk factor for PTBD success and bilirubin reduction were identified in intrahepatic tumors. Moreover, for extrahepatic tumors, PTBD entry at segment 2/3 and segment 5/6 was more likely achieve PTBD success (aOR=3.037 and aOR=1.929, respectively), bilirubin reduction (aOR=3.069 and aOR=3.515) and low complications (aOR=0.102 and aOR=0.126, respectively).DiscussionGood clinical outcomes were observed for PTBD entry at segments 5/6 and 2/3. In contrast, segment 7/8 had the lowest success rate, smallest bilirubin reduction, and the highest complication rate. For patients with obstructive jaundice, PTBD entry in hepatic segments 2/3 and 5/6 is recommended to achieve high success rates and low complications.
C-di-AMP Is a Second Messenger in Corynebacterium glutamicum That Regulates Expression of a Cell Wall-Related Peptidase via a Riboswitch
Authors: Reich Sebastian J. , Goldbeck Oliver , Lkhaasuren Tsenguunmaa , Weixler Dominik , Weiß Tamara , Eikmanns Bernhard J. 
Published: January 2023

Cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger discovered in Bacillus subtilis and involved in potassium homeostasis, cell wall maintenance and/or DNA stress response. As the role of c-di-AMP has been mostly studied in Firmicutes, we sought to increase the understanding of its role in Actinobacteria, namely in Corynebacterium glutamicum. This organism is a well-known industrial production host and a model organism for pathogens, such as C. diphtheriae or Mycobacterium tuberculosis. Here, we identify and analyze the minimal set of two C. glutamicum enzymes, the diadenylate cyclase DisA and the phosphodiesterase PdeA, responsible for c-di-AMP metabolism. DisA synthesizes c-di-AMP from two molecules of ATP, whereas PdeA degrades c-di-AMP, as well as the linear degradation intermediate phosphoadenylyl-(3′→5′)-adenosine (pApA) to two molecules of AMP. Here, we show that a ydaO/kimA-type c-di-AMP-dependent riboswitch controls the expression of the strictly regulated cell wall peptidase gene nlpC in C. glutamicum. In contrast to previously described members of the ydaO/kimA-type riboswitches, our results suggest that the C. glutamicum nlpC riboswitch likely affects the translation instead of the transcription of its downstream gene. Although strongly regulated by different mechanisms, we show that the absence of nlpC, the first known regulatory target of c-di-AMP in C. glutamicum, is not detrimental for this organism under the tested conditions.
PENDUGAAN KEDALAMAN AIR TANAH DENGAN GEOLISTRIK RESISTIVITAS DI DESA TEGALWERU, KECAMATAN DAU, KABUPATEN MALANG
Authors: Chandrasasi Dian , Fidari Jadfan Sidqi , Montarcih Lily 
Published: January 2023

Permasalahan dasar dari ketersediaan air tanah pada umumnya disebabkan oleh sumur warga yang masih cukup dalam (informasi dari warga lebih dari 50 m), sehingga memerlukan biaya penggalian sumur produksi yang sangat mahal terutama bagi warga desa. Masyarakat di Desa Tegalweru Kecamatan Dau Kabupaten Malang banyak yang masih tidak bisa memanfaatkan potensi air tanah di daerah tersebut. Warga menggunakan air bersih hanya bersumber selain dari air tanah. Hal ini disebabkan karena belum adanya informasi terkait dengan keberadaan air tanah. Tujuan penelitian untuk mengetahui lapisan tanah yang memiliki potensi air tanah (akuifer) berdasarkan sebaran nilai resistivitas dan dapat digunakan sebagai dasar pertimbangan dalam pembuatan sumur bor. Berdasarkan pengolahan data geolistrik dan analisanya, potensi air tanah dapat disimpulkan bahwa lokasi pengukuran di lahan kebun memiliki potensi air tanah yang baik dengan diidentifikasinya beberapa susunan akuifer sampai kedalaman 145 meter. Litologi batuan titik geolistrik no 01, 02 dan 03 terdiri dari lapisan top soil, tufa, dan breksi.
PERANCANGAN MEDIA BELAJAR ANTROPOMETRI BERBASIS AUGMENTED REALITY
Authors: Yuamita Ferida , Amalia Ulfa 
Published: January 2023

Media pembelajaran yang digunakan oleh pengajar menjadi faktor penting yang berpengaruh pada tingkat pemahaman peserta didik. Inovasi dalam media pembelajaran di era berkembangnya teknologi saat ini, dapat memberikan kesempatan bagi pendidik untuk selalu berupaya memberikan media pembelajaran yang mudah diakses, dipahami secara mendalam, dan dapat berfungsi secara efektif. Penggunaan strategi pembelajaran yang tepat menjadi suatu metode yang dapat dilakukan pendidik dalam proses penguatan aspek kognitif, afektif, dan juga motorik. Studi awal yang dilakukan Peneliti pada 50 orang mahasiswa Teknik Industri Universitas Teknologi Yogyakarta, menunjukkan bahwa terdapat 32% mengalami kesulitan dalam memahami materi mata kuliah Ergonomi yang berkaitan dengan materi Antropometri (pengukuran dimensi manusia) dikarenakan adanya keterbatasan media dalam proses pembelajaran materi tersebut. Penelitian ini bertujuan menghasilkan rancangan media pembelajaran yang dapat memberikan kemudahan mahasiswa dalam memahami materi Antropometri. Metode penelitian dan pengembangan ini menggunakan model Lee & Owens dengan melakukan 4 tahapan yaitu Assessment/analysis, Design, Development dan implementation, dan tahap Evaluation. Hasil penelitan ini adalah sebuah aplikasi berbasis Augmented Reality yang bernama AR Antropometri. Aplikasi ini memberikan visualisasi 3 dimensi menggunakan teknologi augmented reality dilengkapi dengan materi dan kuis sebagai tolok ukur pencapaian kemudahan mahasiswa dalam memahami materi antropometria.
Análisis de circuitos de flotación utilizando el software de simulación HSC Sim Chemistry
Authors: Fica Jorge Alejandro Manriquez , Donoso Patricio Eugenio Navarro , Riquelme Cristian Alejandro Vargas , Villarroel Hector Javier Alonso Olivera 
Published: January 2023

Se diseñó y evaluó un circuito de flotación mediante simulación en el software HSC versión 6.12, modelado en el módulo “Sim Flowsheet Simulation”, empleando etapas rougher, scavenger y cleaner, sin remolienda y una mineralogía de alimentación compuesta por 0,0012% de oro, 11,2% de FeS2, 3,2% de CuFeS2 y 85,6% de ganga no sulfurosa compuesta por un 90% de SiO2 y un 10% de Al2O3.
El modelo de simulación se basa en el balance másico de los distintos minerales participantes del proceso, con principal atención en los parámetros de operación como lo son mineralogía y leyes de alimentación, tiempos de residencia, fracciones de mineral flotable, medianamente flotable y no flotable con sus respectivas constantes de cinéticas.
Como resultado de las simulaciones que evalúan distintos circuitos, se obtuvieron resultados de ley de cobre en el concentrado de 28,6% y en las colas de un 0,15%, con porcentaje de recuperación de cobre de un 86,5% para un circuito que consta de dos etapas rougher, dos etapas cleaner y dos etapas scavenger.
El modelo permitió determinar el efecto del cambio en el contenido de FeS2 y de los tiempos de residencia en las leyes de concentrado y recuperación de Cu.
Literatura infantojuvenil e educação ambiental: quando os próprios educadores escrevem seus livros
Authors: Tiago Fabiana da Conceição Pereira , De Oliveira Rosália Caldas Sanábio 
Published: January 2023

A Educação Ambiental na Educação Básica almeja dar início a um esboço de alfabetização científica na infância/adolescência, de maneira lúdica e de forma atrativa, contextualizando o que inferimos como meio ambiente e termos correlatos. Como professoras, sempre nos preocupamos em utilizar distintos recursos didático-pedagógicos em sala de aula, dentre estes, os livros infantojuvenis, com o cuidado de averiguarmos suas proposições e discursos, bem como a correção de seus enunciados. Nossos alunos, num quadro geral, frequentaram escolas públicas com pouca infraestrutura e apresentam problemas conceituais de ecologia e meio ambiente. Diante das dificuldades de compreensão de conceitos como Meio Ambiente, Educação Ambiental e percepção ambiental, e a vivência pessoal das docentes, as professoras pensaram em elaborar livros infantojuvenis que possibilitassem a percepção do meio ambiente, a funcionabilidade e a integralidade dos seres vivos com o meio ambiente. Mostrando que todos possuem papéis importantes para a manutenção da vida no planeta Terra. Procurando trabalhar os aspectos cognitivos, em uma linguagem lúdica e reflexiva sobre a alfabetização Ecológica, de acordo com Capra Fritjof, foram elaborados os seguintes livros: “Vovó mora num Vulcão”, “O Boto Cor-de-Rosa que não é mais Rosa”, “Minhoca Milu”, “Abelhas em Fuga”, “Abelha Zung-Zung em: uma Colmeia no Apartamento?!”. A ecoalfabetização pode acontecer em todas as idades, afinal o aprendizado faz parte da vida do ser humano, mas é na infância que o desenvolvimento da percepção ambiental da funcionabilidade da natureza deve ser introduzido, ensinando os conceitos dos ecossistemas e permitindo ao longo da vida ampliar sua visão ecológica de cuidado e preservação.