bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dorsalgias
Authors: Stump Patrick , Forni José Eduardo Nogueira , Teixeira Manoel Jacobsen , Souza Fábio Pires de , Miura Tania Tiemi 
Published: March 2023

As mais freqüentes razões das dorsalgias são as afecções músculo-esqueléticas incluindo as síndromes dolorosas miofasciais da musculatura regional das lesões traumáticas, inflamatórias, degenerativas, tumorais ou constitucionais da coluna vertebral, seguindo-se a dor referida de afecções vertebrais e as neuropatias. Os dados de história clínica e de semiologia e a adequada interpretação dos exames complementares possibilitam diagnóstico na maioria dos casos. O tratamento consiste da remoção dos fatores causais, do uso de medicações analgésicas, antiinflamatórias e ou opióides, psicotrópicos, miorrelaxantes, medidas de medicina física e, em poucos casos, de procedimentos neurocirúrgicos, ortopédicos ou de cirurgia torácica.
Dor torácica
Authors: Gal Patrícia Liliane Marie , Teixeira Manoel Jacobsen Teixeira*, Clement Haman Jacobsen , Bergel Rubens Hirsel , Teixeira William Gemio Jacobsen 
Published: March 2023

Várias são as causas de dor torácica. Dentre elas destacam-se as visceropatias, as neuropatias e as músculo-esqueléticas. Apesar de muito freqüentemente visceropatias serem as razões da dor torácica aguda ou aguda intermitente, as afecções músculoesqueléticas e neuropáticas parecem também representar contigente significativo das razões de dor torácica. Portanto, além da investigação destinada à identificação de anormalidades viscerais, a avaliação das condições músculo-esqueléticas e neurológicas é necessária, especialmente em casos de dor torácica crônica. As intervenções terapêuticas destinadas ao tratamento da dor músculoesquelética incluem medicamentos analgésicos e adjuvantes, procedimentos de medicina física e de psicoterapia. Intervenções neuroanestésicas e neurocirúrgicas são raramente necessárias para o controle da dor torácica.
Dor nos membros inferiores
Authors: Teixeira Manoel Jacobsen , Yeng Lin Tchia , Fernandes Túlio Diniz , Hernandez Arnaldo José , Romano Miriam Aparecida , Forni José Eduardo Nogueira , Amatuzzi Marco 
Published: March 2023

Dor é fenômeno comum nos membros inferiores. Várias são as razões de sua ocorrência. Afecções músculo-esqueléticas,dermatológicas, vasculares, neuropáticas ou viscerais abdominais. Destacam-se as músculo-esqueléticas, especialmente as síndromes dolorosas miofasciais. Os dados de história e de exame clínico e, quando necessário, os exames subsidiários possibilitam diagnóstico preciso na maioria dos casos. O tratamento da condição primária e o uso de medidas analgésicas especialmente de medicamentos antiinflamatórios ou opióides, psicotrópicos, medicina física, psicoterapia e, quando necessário, intervenções neurocirúrgicas funcionais aliviam a dor na maioria dos casos.
Síndromes dolorosas músculo-esqueléticas em crianças
Authors: Okada Massako , Teixeira Manoel Jacobsen , Mori Eduardo 
Published: March 2023

Síndromes dolorosas acometendo o aparelho locomotor e representadas principalmente pela artrite reumatóide juvenil,dores de crescimento, fibromialgia primária, síndrome complexa de dor regional são comuns em pediatria. Os dados de anammese, os antecedentes e o exame físico proporcionam a identificação dessas condições na maioria dos casos. O tratamento específico de cada uma dessas condições associadamente às medidas analgésicas e de reabilitação proporciona melhora da maioria dessas condições
Realização de Papanicolaou em profissionais de saúde
Authors: Silva Ana Cláudia Camargo Gonçalves da , Bloch Leila David , Freitas Filho Marco Antonio Paes de , Eluf Neto José 
Published: March 2023

A abordagem mais efetiva para a redução da morbidade e mortalidade do câncer de colo uterino é o rastreamento por citologia cervical (Papanicolaou). Este estudo transversalteve como objetivo avaliar a realização e o conhecimento sobre o teste de Papanicolaou em auxiliares de enfermagem. Os indivíduos foram selecionados de modo aleatório entre profissionais que trabalham no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, com idade entre 40 e 69 anos. Foi aplicado um questionário semi-estruturado em 95 auxiliares de enfermagem (média de idade - 46,7 anos, desvio-padrão - 5,5). Noventa mulheres(94,7%) haviam realizado o teste como rastreamento. Quanto à finalidade do exame, somente 39 (41,0%) apontaram a detecção ou a prevenção do câncer de colo de útero. Por outro lado, 91 das (95,8%) auxiliares acreditam que o Papanicolaou deveria ser colhido com periodicidademenor ou igual a 1 ano, e 45 (47,4%) com seis meses ou menos. Conclusão: Apesar da maioria das auxiliares de enfermagem terem conhecimento parcial a respeito da finalidade do Papanicolaou, a prática deste teste é mais elevada do que na população geral. Além disso, essas profissionais de saúde consideram que a freqüência de realização do exame deveria ser bem maior do que a preconizada.
Judicialisation of the Sea: An Elaboration of Our Argument and Its Merits
Authors: McLaughlin Mitchell Sara , Owsiak Andrew P. 
Published: March 2023

Abstract
In a previous article, we theorised that courts cast a shadow that changes the bargaining behaviour of potential litigant States. When two States prefer the same judicial forum under Article 287 of the United Nations Convention on the Law of the Sea (LOSC), they have fewer maritime disputes, more peaceful negotiations, and less need for judicial dispute settlement. This article elaborates on several aspects of our argument including (i) differences in legal and social science perspectives, (ii) generalizability to other courts and regions, (iii) the clarity of judicial decisions, (iv) whether accepting the same judicial forum through Article 287 declarations matters, (v) conflict management as a process, (vi) how domestic legal traditions influence Article 287 declarations, and (vii) the possibility of selection or heterogeneous effects. Our discussion helps to address some of the criticisms raised in the AJIL Unbound (2021) forum on our article and presents avenues for future analyses.
Hydraulic architecture of crown in three Brazilian species
Authors: Pereira Lopes Olívia , Buttò Valentina , Rossi Sergio , Zanatto Bruna , Angeles Guillermo , Longui Eduardo Luiz 
Published: March 2023

Summary
The hydraulic limitation hypothesis postulates an increase in resistance to water conductivity as trees become taller. Accordingly, we expect that the hydraulic architecture of trees shares a close relationship with the crown architecture and that anatomical traits can directly or indirectly influence hydraulic conductivity. The aim of this work was to investigate the variations in vessels, hydraulic properties and wood density of three native Brazilian tree species. We selected 40-year-old Balfourodendron riedelianum, Cariniana legalis and Handroanthus vellosoi trees and measured maximum vessel length, specific hydraulic conductivity, the percentage loss of conductivity, leaf hydraulic conductivity, and density of branches at three different positions of the crown. Variability in anatomical and hydraulic properties was mostly explained by differences between species, while small differences were related to the position of the branch along the crown-position gradient. Within the measured variables, only the maximum vessel length differed between one crown position and the other. We posit that poor differences between anatomical and hydraulic positions in the crown-position gradient could be related to sample positions within the crown, which were relatively close to each other, with branches having similar ages and diameters. Our findings demonstrate that despite growing in the same environment and having the same age, our species deploy contrasting carbon allocation and hydraulic species-specific strategies. These strategies mirror different growth performances resulting from a different trade-off between hydraulic capacity and safety.
Political Thought and Race Ideas in Brazil: Oliveira Vianna and Gilberto Freyre
Authors: Passos Eduardo Schmidt 
Published: March 2023

Abstract
This article engages in a comparative study of political ideas to understand the influence of different race ideas in political thought and institutions. In the early 20th century, two Brazilian social scientists dealt with this problem in their interpretations of Brazilian socio-political reality. The jurist and sociologist Oliveira Vianna, equipped with the positive science of his time, analyzed Brazilian racial heterogeneity through the lenses of biology and social psychology and proposed an authoritarian technocracy to solve Brazil’s political problems. Contrary to this interpretation, the sociologist and anthropologist Gilberto Freyre proposed a cognitive revolution by discrediting racist theories and forging a new self-representation of Brazilian society as an “ethnic democracy.” This comparison shows how Freyre’s ideas are relevant in overcoming racial prejudice and understanding the formation of Brazilian democracy and collective identity.
Diurnal MCSs Precede the Genesis of Tropical Cyclone Mora (2017): The Role of Convectively Forced Gravity Waves
Authors: Chen Xingchao , Leung L. Ruby , Feng Zhe , Yang Qiu 
Published: March 2023

Abstract
A novel high-resolution regional reanalysis is used to investigate the mesoscale processes that preceded the formation of Tropical Cyclone (TC) Mora (2017). Both satellite observations and the regional reanalysis show early morning mesoscale convective systems (MCSs) persistently initiated and organized in the downshear quadrant of the preexisting tropical disturbance a few days prior to the genesis of TC Mora. The diurnal MCSs gradually enhanced the meso-α-scale vortex near the center of the preexisting tropical disturbance through vortex stretching, providing a vorticity-rich and moist environment for the following burst of deep convection and enhancement of the meso-β-scale vortex. The regional reanalysis shows that the gravity waves that radiated from afternoon convection over the northern coast of the Bay of Bengal might play an important role in modulating the diurnal cycle of pregenesis MCSs. The diurnal convectively forced gravity waves increased the tropospheric stability, reduced the column saturation fraction, and suppressed deep convection within the preexisting tropical disturbance from noon to evening. A similar quasi-diurnal cycle of organized deep convection prior to TC genesis has also been observed over other basins. However, modeling studies are needed to conclusively demonstrate the relationships between the gravity waves and pregenesis diurnal MCSs. Also, whether diurnal gravity waves play a similar role in modulating the pregenesis deep convection in other TCs is worth future investigations.

Significance Statement
Tropical cyclogenesis is a process by which a less organized weather system in the tropics develops into a tropical cyclone (TC). Observations indicate that thunderstorms occurring prior to the tropical cyclogenesis often show a distinct quasi-diurnal cycle, while the related physical mechanisms are still unclear. In this study, we used a novel high-resolution dataset to investigate the diurnal thunderstorms occurring prior to the genesis of TC Mora (2017). We find that the pregenesis diurnal thunderstorms played a crucial role in spinning up the circulation of the atmosphere and provided a favorable environment for the rapid formation of Mora. It is likely that gravity waves emitted by afternoon thunderstorms over the inland region were responsible for regulating the diurnal variation of pregenesis thunderstorms over the ocean.
AERONET-OC LWN Uncertainties: Revisited
Authors: Cazzaniga Ilaria , Zibordi Giuseppe 
Published: March 2023

Abstract
The Ocean Color Component of the Aerosol Robotic Network (AERONET-OC) aims at supporting the assessment of satellite ocean color radiometric products with in situ reference data derived from automated above-water measurements. This study, applying metrology principles and taking advantage of recent technology and science advances, revisits the uncertainty estimates formerly provided for AERONET-OC normalized water-leaving radiances LWN. The new uncertainty values are quantified for a number of AERONET-OC sites located in marine regions representative of chlorophyll-a-dominated waters (i.e., Case 1) and a variety of optically complex waters. Results show uncertainties typically increasing with the optical complexity of water and wind speed. Relative and absolute uncertainty values are provided for the various sites together with contributions from each source of uncertainty affecting measurements. In view of supporting AERONET-OC data users, the study also suggests practical solutions to quantify uncertainties for LWN from its spectral values. Additionally, results from an evaluation of the temporal variability characterizing LWN at various AERONET-OC sites are presented to address the impact of temporal mismatches between in situ and satellite data in matchup analysis.
A Multivariable Convolutional Neural Network for Forecasting Synoptic-Scale Sea Surface Temperature Anomalies in the South China Sea
Authors: Miao Yonglan , Zhang Cuicui , Zhang Xuefeng , Zhang Lianxin 
Published: March 2023

Abstract
The sea surface temperature anomaly (SSTA) plays a key role in climate change and extreme weather processes. Usually, SSTA forecast methods consist of numerical and conventional statistical models, and the former can be seriously influenced by the uncertainty of physical parameterization schemes, the nonlinearity of ocean dynamic processes, and the nonrobustness of numerical discretization algorithms. Recently, deep learning has been explored to address forecast issues in the field of oceanography. However, existing deep learning models for ocean forecasting are mainly site specific, which were designed for forecasting on a single point or for an independent variable. Moreover, few special deep learning networks have been developed to deal with SSTA field forecasts under typhoon conditions. In this study, a multivariable convolutional neural network (MCNN) is proposed, which can be applied for synoptic-scale SSTA forecasting in the South China Sea. In addition to the SSTA itself, the surface wind speed and the surface current velocity are regarded as input variables for the prediction networks, effectively reflecting the influences of both local atmospheric dynamic forcing and nonlocal oceanic thermal advection. Experimental results demonstrate that MCNN exhibits better performance than a single-variable convolutional neural network (SCNN), especially for the SSTA forecast during the typhoon passage. While forecast results deteriorate rapidly in the SCNN during the passage of a typhoon, forecast errors in the MCNN can be effectively restrained to slowly increase over the forecast time due to the introduction of the surface wind speed in this network.
Silk fibroin-hydroxyapatite scaffolds promote the proliferation of adipose-derived mesenchymal stem cells by activating the ERK signal
Authors: Xie Xingqiao , Miao Bianliang , Yao Jinrong , Chen Zhongchun 
Published: March 2023

Adipose-derived mesenchymal stem cell (Ad-MSC) with capacities of releasing trophic factors and chondrogenic differentiation was a promising candidate for tracheal reconstruction. Silk fibroin (SF)- hydroxyapatite (HA) scaffolds were fabricated by the freeze-drying method. And Ad-MSCs were co-cultured on the scaffolds for 14 days in vitro. The role of the SF-HA scaffold in regulating the adhesion, growth, and proliferation of Ad-MSCs, and its potential mechanisms were investigated. The identity of Ad-MSCs was confirmed by cell morphology, surface markers, and differentiation characteristics. Cell proliferation, viability, and morphology were observed via CCK-8, live/dead assay, and scanning electron microscopy (SEM). Gene mRNA and protein levels were examined using quantitative real-time polymerase chain reaction and western blotting, respectively. SF-HA scaffolds showed excellent properties of promoting Ad-MSCs adhesion, growth, and proliferation for at least 14 days. In the CCK-8 assay, the relative OD value of Ad-MSCs cultured on SF-HA scaffolds increased ( p < 0.001). Furthermore, live/dead staining showed that the fluorescent coverage increased with time ( p < 0.05). SEM also showed that 3 days after inoculation, the coverage of Ad-MSCs on the SF-HA scaffolds was 78.15%, increased to 92.91% on day 7, and reached a peak of 94.38% on day 14. Extracellular signal-regulated kinase (ERK) mRNA and phosphorylated ERK (pERK) protein expression increased at day 3 ( p < 0.05), followed by a significant decline at day 7 ( p < 0.05). And ERK mRNA expression was positively correlated with Ad-MSCs proliferation ( p < 0.05). In summary, the SF-HA scaffold co-cultured with Ad-MSCs is a promising biomaterial for tracheal repair by activating the ERK signal pathway.
Correlation of Calculated Vancomycin Trough Concentrations and Exposure: A Monte Carlo Simulation
Authors: Haag Hans , Lau Anthony 
Published: March 2023

Background: Current recommendations are to dose vancomycin to target 24-hour area under the curve (AUC) of 400-600 mg·h/L to optimize efficacy and safety. Limited data support AUC monitoring, and some centers continue to use trough concentrations. A target of 10-20 mg/L has been proposed to reduce nephrotoxicity risk. Objective: To use previously published pharmacokinetic equations in a Monte Carlo simulation relating AUC exposure to trough concentrations when targeting an AUC between 400 and 600 mg·h/L. Methods: Previously published pharmacokinetic data were used as input parameters for a Monte Carlo simulation using previously published formulae to correlate AUC to simulated trough concentrations. Pharmacokinetic parameters were assumed to occur in a normal distribution pattern. We excluded irrelevant simulated cases. Maintenance doses of 15 mg/kg were rounded to the nearest 250 mg. Calculated trough concentrations for AUCs of both 400 and 600 mg·h/L were evaluated in each simulation. Results: A total of 10 000 Monte Carlo simulations were performed. Targeting an AUC of 400 mg·h/L resulted in a mean trough concentration of 10.3 ± 0.8 mg/L. Targeting an AUC of 600 mg·h/L resulted in a mean trough concentration of 15.4 ± 1.2 mg/L. Conclusion and Relevance: We demonstrate that a lower trough concentration range may be supported by an AUC of 400-600 mg·h/L, which may reduce risk and rates of nephrotoxicity without compromising previously established efficacious target trough concentrations.
Changes in corneal endothelial cell density after trabeculectomy
Authors: Lee Natalie Si-Yi , Ong Ru Min , Ong Keith 
Published: March 2023

Background Glaucoma is a leading cause of blindness worldwide for which trabeculectomy is the most effective surgical intervention for advanced disease. However, trabeculectomy has been associated with alterations to corneal endothelium, including a decrease in corneal endothelial cell density (CECD). The purpose of this study was to investigate changes in CECD after trabeculectomy, and identify factors contributing to cell loss, such as pre-operative biometry and lens status. Methods This retrospective study included 72 eyes of 60 patients who underwent trabeculectomy between January 2018 and June 2021 at two private hospitals. Demographic and clinical data were obtained at baseline. Corneal specular microscopy was performed pre-operatively and at 6 months after surgery. CECD was evaluated and compared between groups to quantify changes to corneal endothelium and identify significant factors affecting decreases in cell density. Results Mean CECD was 2284.66 ± 375.59 pre-operatively and 2129.52 ± 401.96 after 6 months ( p < 0.001). A greater decrease in CECD ( p = 0.005) was observed in phakic eyes (235.45 ± 118.32) compared to pseudophakic eyes (137.82 ± 107.30). The amount of cell loss was negatively correlated with pre-operative central corneal thickness ( p = 0.009) and anterior chamber (AC) depth ( p = 0.033). There were no significant correlations between changes to CECD and patient age, gender, number of pre-operative glaucoma medications and number of post-operative antifibrotic agents. Conclusions Significant decreases in CECD occurred after trabeculectomy. Less corneal endothelial cell loss occurred in pseudophakic eyes. Hence, if patients need trabeculectomy and cataract surgery, it may be better to perform cataract surgery first. Longer term studies should derive more information.
Latrine Utilization and Associated Factors Among Rural Households in Southwest Ethiopia: Risk, Attitude, Norms, Ability, and Self-Regulation Behavioral Model
Authors: Bamlaku Golla Eyasu , Gelgelu Temesgen Bati , Deguale Adane Mikael , Tsegaye Giday Tesfaye , Asres Abiyot Wolie , Adafrie Takele Tadesse 
Published: March 2023

Background: Consistent latrine utilization remains a challenge in most rural areas of poor and middle-income countries including Ethiopia. Therefore; the objective of this study was to determine the magnitude of latrine utilization and its associated factors among rural households in open defecation-free declared (ODF) and non-ODF kebeles, Southwest Ethiopia, 2022. Methods: A community-based comparative cross sectional study design was employed from May 16 to June 14, 2022 among 682 (341 ODF and 341 non-ODF) rural households which were selected by multistage systematic random sampling technique. Data were collected by face to face using a pretested structured questionnaire and an observational checklist through Open data kit. SPSS version 26 was used to analysis the data and separate logistic regression models; ODF and non-ODF were run to identify the associated factors. P-values <.05 with 95% CI were set as statistical significant. Result: The overall magnitude of latrine utilization in the study area was 67.1% (95% CI: 63.71, 70.49). Latrine utilization was higher in ODF declared households (71.6%) than in non-ODF households (62.5%). In ODF; Graduated as model households [AOR = 5.1, 95% CI: 2.14, 12.84], visited by health extension works (HEWs) [AOR = 3.5, 95% CI: 1.67, 7.25], and latrine with privacy [AOR = 3.0, 95% CI: 1.37, 6.65] and also in non-ODF; households visited by HEWs [AOR = 2.9, 95% CI: 1.34, 6.06], latrine with privacy [AOR = 2.5, 95% CI: 1.24, 5.07], positive attitude [AOR = 3.2, 95% CI: 1.52, 6.59], and descriptive norm [AOR = 2.7, 95% CI: 1.27, 5.53] were significantly associated with latrine utilization. Conclusion: This study found that rural households declared as ODF utilize their latrine higher than non-ODF. Constructing latrine without privacy, lack of follow up, Attitude and societal norms were factors that limited the utilization of latrine and the sustainability of ODF. Therefore, health extension follow-up, latrine construction with privacy, normative and persuasive behavior change approach should be encouraged.