bluuebunny/crossref_metadata_2025_split huggingface dataset:
MSC.sensor: capturing cancer cell interactions with stroma for functional profiling
Authors: Huang Yun , Drakul Aneta , Sidhu Jasmeet , Rauwolf Kerstin , Kim James , Bornhauser Beat , Bourquin Jean-Pierre 
Published: March 2023

Abstract
Mesenchymal stromal cells (MSCs) contribute to the microenvironment regulating normal and malignant hematopoiesis, and thus may support subpopulations of cancer cells to escape therapeutic pressure. Here, we engineered bone marrow MSCs to express a synthetic CD19-sensor receptor to detect and display interacting primary CD19+ leukemia cells in coculture. This implementation provides a versatile platform facilitating ex vivo drug response profiling of primary CD19+ leukemia cells in coculture with high-sensitivity and scalability.
Intra-arterial Versus Intravenous Chemoradiotherapy for Maxillary Sinus Squamous Cell Carcinoma
Authors: Iuchi Hiroyuki , Ohori Junichiro , Haraguchi Megumi , Toge Sakiko , Yamashita Masaru 
Published: March 2023

Abstract
Background
The surgical treatment of maxillary sinus cancer may be declined by patients from a functional and cosmetic point of view. Treatment methods other than surgery include intra-arterial and intravenous chemoradiotherapy. The purpose of this study was to evaluate the utility of intra-arterial chemoradiotherapy (RADPLAT) compared with that of intravenous chemoradiotherapy for patients with squamous cell carcinoma of the maxillary sinus (MS-SCC).
Methods
We retrospectively reviewed the records of 22 patients with MS-SCC histologically confirmed from January 2008 to January 2021. The patients underwent RADPLAT or intravenous chemoradiotherapy. Cumulative survival was analyzed using the Kaplan-Meier method; we specifically analyzed overall survival (OS), progression-free survival (PFS), and locoregional recurrence-free survival (LRFS).
Results
One patient (5%) was diagnosed with T2 disease, 5 (23%) with T3 disease, and 16 (72%) with T4 disease. The median follow-up time was 29.5 months. Seventeen patients underwent RADPLAT, and 5 patients underwent intravenous chemoradiotherapy with Cisplatin (CDDP). Nine patients each experienced grade 3 toxicity during the two treatments. The 3-year OS, PFS, and LRFS rates of patients who underwent RADPLAT were 82%, 65%, and 77%, respectively. The 3-year OS, PFS, and LRFS rates of patients who underwent intravenous chemoradiotherapy with CDDP were 60%, 20%, and 20%, respectively. Only the LRFS rate was statistically significant (p=0.029).
Conclusions
This study suggests that RADPLAT is more useful than intravenous chemoradiotherapy in terms of local control in treating MS-SCC patients who refuse surgery.
WITHDRAWN: Prussian blue analogue derived nitrogen‒carbon mixed metal sulfides heterostructure for asymmetric supercapacitors
Authors: Wu Yuan , Chen Xudong , Zhou Yang , Wu Cunqi , Li Lei , Xu Zhenming , Zhang Xiaogang , Tong Hao 
Published: March 2023

Abstract
Prussian blue analogues (PBAs) have the advantages of stable electrochemical performance and long service life when used as energy storage materials due to their face‒centered cubic structure. Here, Ni‒Co Prussian blue analogue (PBA) nano units have been utilized as precursor to prepare corresponding metal sulfide derivatives, which inherited the structural properties of the precursor. This unique structural exposes more reaction sites and the generation of a small amount of nitrogen-doped carbon that enhances charge transfer. This cube structure has a buffer effect on the stress of the active substance during charging and discharging. The CoS2/Ni3S4‒N‒C provides a capacitance of 817 C g‒1 at 3 A g‒1 and there is still 556 C g‒1 at 20 A g‒1. Furthermore, CoS2/Ni3S4‒N‒C electrode yields outstanding cycle stability (98.2% capacitance retention at 10,000 cycles). An asymmetric supercapacitor (ASC) device consisting of CoS2/ Ni3S4‒N‒C and activated carbon electrodes have an energy density of 40 Wh kg‒1, and a retention rate of 103.7% for 10,000 cycles at 10 A g‒1, presenting excellent cycle stability. The electron properties of Co2NiO4 and CoS2/Ni3S4 − N−C are compared by density functional theory (DFT). CoS2/Ni3S4 − N−C detects more DOS near the Fermi level, leading to larger charge accumulation, indicating that the electron conductivity of the heterojunction is much higher than that of the oxide, and eventually faster reaction kinetics can be obtained.
Fréchet-Urysohn property of quasicontinuous functions
Authors: Osipov Alexander 
Published: March 2023

Abstract
The aim of this paper is to study the Fréchet-Urysohn property of the space Qp(X,R) of real-valued quasicontinuous functions, defined on a Hausdorff space X, endowed with the pointwise convergence topology.
It is proved that under Suslin's Hypothesis, for an open Whyburn space X, the space Qp(X,R) is Fréchet-Urysohn if and only if X is countable. In particular, it is true in the class of first-countable regular spaces X.
In ZFC, it is proved that for a metrizable space X, the space Qp(X,R) is Fréchet-Urysohn if and only if X is countable.
2010 MSC: 54C35, 54C40
Clinical Efficacy of ECMO in the Treatment of AMI Complicated with Refractory CS
Authors: Qu Wenjing , Lu Andong , Pan Chenliang , Cai Weiting , Wa Yongling , Lei Peng , Hu Sixiong , Zhao Jing , Bai Ming 
Published: March 2023

AbstractObjective:The aim of this single-centre retrospective study was to investigate the efficacy of extracorporeal membrane oxygenation (ECMO) in the treatment of acute myocardial infarction (AMI) complicated by refractory cardiogenic shock (CS).Background:While mechanical circulatory support (MCS) devices are widely used in reperfusion therapy, no significant reduction in mortality has been observed. ECMO is a rescue tool for patients refractory CS, with a paucity of data evaluating its efficacy in the treatment of AMI complicated with refractory CS.Methods:All consecutively enrolled patients with AMI and refractory CS admitted to the First Hospital of Lanzhou University from July 1, 2015, to October 31, 2021, were enrolled. According to the MCS device, the patients were divided into the ECMO and IABP groups. The primary outcome of our study was 30-day mortality. Secondary outcomes included perioperative mortality, 90-day mortality, renal failure requiring CRRT, life-threatening bleeding, moderate bleeding, ischaemic complications, and bacteremia.Results:A total of 81 patients, with a mean age of 62 ± 10 years, were included, 79% of them were males. Forty-four patients (54.3%) were included in the IABP group, and 37 (45.7%) were included in the ECMO group. The average lactate level was 7.05 ± 3.56 mmol/L. A total of 72.0% of patients had multivessel coronary artery disease (CAD). Compared with IABP, ECMO led to lower 30-day mortality (68.2% vs. 43.2%, χ2=8.423, P=0.004) and perioperative mortality rates (20.0% vs. 0.00%, χ2=5.877, P=0.015) but prolonged the patient's CCU (10.0 vs. 3.5, p < 0.001) and total hospital stay (13 vs. 4, p < 0.001). In the subgroup analysis of multivessel CAD, the 30-day mortality rate in the ECMO group who underwent immediate multivessel PCI was significantly lower than that in those who initially underwent PCI of the culprit lesion only (21.4% vs. 61.5%, χ2=4.402, P=0.036).Conclusion:ECMO can significantly reduce the risk of 30-day mortality and does not increase the risk of serious complications. In addition, immediate multivessel PCI with ECMO can significantly reduce 30-day mortality in patients with multivessel CAD.
Authentication of a survival nomogram for non-invasive micropapillary breast cancer
Authors: Zhang Mingkun , Qin Yuan , Hou Niuniu , Ji Fuqing , Zhang Zhihao , Zhang Juliang 
Published: March 2023

Abstract
Purpose
We aimed at establishing a nomogram to accurately forecast the overall survival (OS) of non-metastatic invasive micropapillary breast carcinoma (IMPC).
Methods
In the training cohort, data from 429 patients with non-metastatic IMPC were obtained through the Surveillance, Epidemiology, and End Results (SEER) database. Other 102 patients were enrolled at the Xijing Hospital as validation cohort. Independent risk factors affecting OS were ascertained using univariate and multivariate Cox regression. A nomogram was established to forecast OS at 3, 5 and 8 years. The concordance index (C-index), the area under a receiver operating characteristic (ROC) curve and calibration curves were utilized to assess calibration, discrimination and predictive accuracy. Finally, the nomogram was utilized to stratify the risk. The OS between groups was compared through Kaplan-Meier survival curves.
Results
The multivariate analyses revealed that race (p = 0.047), surgery (p = 0.003), positive lymph nodes (p = 0.027), T stage (p = 0.045) and estrogen receptors (p = 0.019) were independent prognostic risk factors. The C-index was 0.766 (95% CI, 0.682–0.850) in the training cohort and 0.694 (95% CI, 0.527–0.861) in the validation cohort. Furthermore, the predicted OS was consistent with actual observation. The AUCs for OS at 3, 5 and and 8 years were 0.786 (95% CI: 0.656–0.916), 0.791 (95% CI: 0.669–0.912), and 0.774 (95% CI: 0.688–0.860) in the training cohort, respectively. The area under the curves (AUCs) for OS at 3, 5 and 8 years were 0.653 (95% CI: 0.498–0.808), 0.683 (95% CI: 0.546–0.820), and 0.716 (95% CI: 0.595–0.836) in the validation cohort, respectively. The Kaplan-Meier survival curves revealed a significant different OS between groups in both cohorts (p༜0.001).
Conclusion
Our novel prognostic nomogram for non-metastatic IMPC patients achieved a good level of accuracy in both cohorts and could be used to optimize the treatment based on the individual risk factors.
PHQ-9 scores for depression associated with high prevalence of thyroid disease in US adults: a cross-sectional study
Authors: Zou¹ Lai-bin , Chen¹ Hao , Cao¹ Tian-sheng , Wu¹ Hong-sheng , Ma¹ Ke-qiang 
Published: March 2023

Abstract
Objective

Thyroid disease is a very common disease in the world, but the risk factor is not fully clear about present. This study aims to assess the relationship between Patient Health Questionnaire-9 (PHQ-9) scores for depression and the prevalence of thyroid disease in United States (US) adults.

Methods

All samples of the study came from NHANES database from 2017–2020 pre-pandemic. Three different variable models were established; and the logistic regression analyses, generalized additive model, smoothed curve fitting, threshold effect analysis, subgroup analyses were used to assess the relationship between PHQ-9 scores for depression and the prevalence of thyroid disease.

Results

The results suggested that there is a positive relationship between PHQ-9 scores and the prevalence of thyroid disease, and the effect value was 1.0462(1.0311, 1.0615); each unit increase in PHQ-9 scores were associated with a 4.62% increase in the prevalence of thyroid disease. The threshold effect analysis found that log-likelihood ratio was P = 0.042, the inflection points K = 8. When the inflection points were less than 8, The incidence rate of thyroid disease increased by 7.15% for every one unit increase in PHQ-9 scores (P＜0.05); when K was greater than 8, the result was no significant difference. And the relationship between them was very stable according to subgroup analyses.

Conclusions

PHQ-9 scores for depression were positively associated with the prevalence of thyroid disease; the higher PHQ-9 scores of the minimal or mild depression in US adults, the prevalence of thyroid disease is higher; while there was no significant difference in moderately and severe depression adults. However, the causal relationship between the prevalence of thyroid disease and PHQ-9 scores for depression is not clear at present, further research is needed to explore.
Diagnosis and Treatment of Terrible Triad Injury of the Elbow with An Isolated Bone Fragment: A Case Report and Literature Review
Authors: Li Lei , Li Meng , Liu Lei , Xu Wei , Yao Gang , Fang Shiyuan 
Published: March 2023

Abstract
Background

An isolated radial head fracture fragment was rarely seen on the medial side from terrible triad injury. To date, this fracture pattern has not been previously reported and the mechanism of injury remains unknown.

Case Presentation

A 37-year-old male suffered the deformity and swelling of left elbow joint after falling from a high place. He was was rushed to the emergency room of the local hospital for reduction and cast immobilization of the dislocated elbow joint. This case described the rarely medial displacement of radial head fracture fragment from terrible triad injury of the elbow, including the radiologic characteristics and possible mechanisms of injury. The combination of medial and lateral incisions was performed and the patient obtained a good recovery.

Conclusions

The variants of the terrible triad injury of the elbow should be constantly recognized. A detailed surgical plan and favorable prognosis attributed to the the accurate judgment of the fracture and soft tissue injury. Additionally, an assistant incision is often necessary to remove the medial radial head fracture fragment.
Acute penile pain as a presentation of pulmonary embolism: a case report
Authors: Leng Tomas , Leff Rebecca , Milojkovic Klara , O'Sullivan Donnchadh , Schwartz Jonathan , Anderson Jana 
Published: March 2023

Abstract
Background

Pulmonary embolism (PE) in the pediatric population is uncommon, and due to a silent presentation often unrecognized entity that remains one of the most challenging medical conditions in the emergency department (ED). Risk factors for PE in children include nephrotic syndrome, immobility, obesity, congenital heart disease, and malignancy. In patients with PE, thromboembolism has been reported to occur at unusual venous sites including the veins within the central nervous system and abdomen. Although penile pain is a rare presenting symptom in the ED, in patients with hypercoagulability, it can herald a life threating event such as PE prompting further evaluation.

Case presentation

A 15-year-old male with a history of B-cell acute lymphoblastic leukemia who presented to the ED with an 18-hour history of penile pain. In the ED, the patient was in acute distress and rated his pain as 9/10. Initial vital signs were within normal limits, except mild tachypnea. On physical examination, his penile shaft was erythematous, indurated, and tender to palpation. He received fentanyl and morphine for pain. A complete blood cell count revealed pancytopenia with a platelet count of 73 x 109/L (139–320 x 109/L). A work-up for sexually transmitted diseases, urolithiasis, urinary tract infection, deep venous thrombosis (DVT), and priapism was negative. Approximately two hours after morphine administration, his saturations started dropping to mid-70’s. A computed tomography pulmonary angiogram (CTPA) revealed bilateral segmental acute pulmonary embolism involving multiple segmental right and left lower lobe pulmonary arteries. Penile pain and hypoxia have resolved with heparin.

Conclusions

PE is easily missed diagnosis among children who present to the ED and can be potentially fatal. A high index of suspicion is required in asymptomatic and oligo-symptomatic children with prothrombotic risk factors who develop thromboembolism-related symptoms at unusual sites as well as hypoxia in the ED setting.
Perfect planar polyynic cyclo[n]carbon complexes [Cs©C18]+ and [Na©C14]+ with alkaline-metal centers exhibiting record coordination numbers and transition metal behaviors
Authors: Zhang Min , Yuan Rui-Nan , Wu Yan-Bo , Chen Qiang , Wei Zhihong , Li Si-Dian 
Published: March 2023

AbstractSearching for the maximum coordination number (CN) in planar species with novel bonding patterns has fascinated chemists for many years. Using the experimentally observed cyclo[18]carbonD9hC18and theoretically predicted cyclo[14]carbonD7hC14as effective ligands and based on extensive first-principles theory calculations, we predict herein their perfect planar alkaline-metal-doped complexesD9hCs©C18+(1) andD7hNa©C14+(4) which, as the global minima of the systems with an alkaline metal atom located exactly at the center, possess the record coordination numbers of CN = 18 and 14 in planar species, respectively. More interestingly, detailed energy decomposition and adaptive natural density partitioning bonding analyses indicate that the hypercoordinate alkaline-metal centers in these σ + π dually aromatic complexes exhibit obvious transition metal behaviors, with effective in-plane (π-6s)σ, (π-7p)σ, and (π-5d)σ coordination bonds formed in Cs©C18+(1) and (π-3s)σ, (π-3p)σ, and (π-3d)σ coordination interactions fabricated in Na©C14+(4) to dominate the overall attractive interactions between the metal center and its cyclo[n]carbon ligand. Similar dually aromatic alkaline-metal-centered planarCsCs©C17B (2),C2vCs©C17-(3),C2vNa©C13B (5), andC2vNa©C13-(6) have also been obtained with CN = 18, 17, 14, and 13, respectively.
Latent Class Analysis for Health-Related Quality of Life in Nurses in China
Authors: Zhao Yan , Wu Xiaoyi , Liu Kao , Li Qing , Hu Lulu , Wei Ning , Chu Jianying 
Published: March 2023

Abstract
Background
This study aimed to identify the types of quality of life (QoL) based on the five dimensions of the EQ-5D and predict factors affecting QoL.
Methods
A multistage stratified cluster sampling survey was conducted among the staff of 12 general hospitals, 1965 nurses completed the survey, and the data were analysed using SPSS 26.0 and Mplus 8.3 for latent analysis.
Results
Three latent classes of QoL were identified: low-level (2.8%), pain and discomfort (7.6%), medium-level (47.1%), and high-level (42.5%). The types and characteristics of QoL differed among these latent classes. The low-level group had the lowest EQ visual analogue scale (EQ-VAS) score (F = 75.217, P < 0.001) and the highest K10 score (F = 61.90, P < 0.001). Moreover, increased age (OR = 0.819, 95% CI: 0.817–0.973), never having drunk alcohol (OR = 0.107, 95% CI: 0.023, 0.488), and increased EQ-VAS scores (OR = 0.935, 95% CI: 0.919, 0.952) were protective factors for quality of life, while working in obstetrics and gynaecology (OR = 6.457, 95% CI:1.852, 22.512) and higher K10 scores (OR = 1.153, 95% CI: 1.100, 1.209) were risk factors for quality of life.
Conclusion
The results indicated significant heterogeneity in the types of QoL and identified predictors of QoL. These findings provide basic information for the development of nursing interventions to improve quality of life and identified specific characteristics that should be considered during intervention development.
An analysis of ridesharing trip time pre- and amid-COVID-19 pandemic using advanced text mining technique – the USA vs Indian case study across different age and gender groups
Authors: Xu Wenxiang , Sobhani Anae , Fu Ting , Khabooshani Amir Mahdi , Vazirinasab Aminreza , Shokoohyar Sina , Sobhani Ahmad , Raouf Behnaz 
Published: March 2023

Abstract
With the spread of the Covid-19 virus, the public transportation industry faced new challenges. This disease may have affected the decision of users in choosing travel modes by diluting the strengths of ridesharing. In this study, our aim was to investigate the opinions of users on the Twitter application pre- and post-pandemic about travel time in ridesharing. For this purpose, we analyzed 63,800 tweets from January 1, 2019 to April 30, 2022, focusing on the countries of the United States and India, taking into account the characteristics of users such as age and gender. The method we used was LDA for topic modelling and BERT for sentiment analysis. Our results show that trip time happening, such as mornings and other times, became more important after COVID-19 and users' concern about waiting time has increased. After the pandemic, men are more worried about the waiting time, while women and younger groups are worried about the time cost. Before the pandemic, older people gave more importance to waiting time, but after the pandemic, they are more concerned about the time cost and the trip time happening. We also found that women and US users were more positive than others about ridesharing trip time in the pre-pandemic era. Our findings showed that two main factors, the pandemic and the country, greatly affect sentiment, and the positive sentiment of the users of both countries increased after the epidemic, which was higher among all groups for the elderly and American users. Our results can be used to analyze the sentiments of ridesharing industry users in order to compete with other public transportation companies by providing better services and designing a standard to improve travel time.
Oxytocin neurons in the paraventricular nucleus of the hypothalamus circuit-dependently regulates social behavior, which malfunctions in BTBR mouse model of autism
Authors: Arakawa Hiroyuki , Higuchi Yuki , Ozawa Akihiko 
Published: March 2023

Abstract
Oxytocin (OXT) a neuropeptide synthesized in the hypothalamic nuclei has a variety of function including socio-emotional processes in mammals. While the neural circuits and signaling pathways in central OXT converge in the paraventricular nucleus of the hypothalamus (PVN), we illuminate specific function of discrete PVN OXT circuits, which connect to the medial amygdala (MeA) and the bed nucleus of the stria terminalis (BnST) in mouse models. The OXTPVN→BnST projections are innervated from entire portions of the PVN, while those OXTPVN→MeA projections are asymmetrically innervated from the posterior portion of the PVN. Compared with OXT neurons in B6 wild type mice, BTBR mice that are recognized as a behavior-based autism model exhibited defect in the OXTPVN→BnST projection. We demonstrate that chemogenetic activation of OXTPVN→MeA circuit enhances anxiety-like behavior and facilitates social approach behavior, while activation of OXTPVN→BnST circuit suppresses anxiety-like behavior along with inhibiting social approach. This chemogenetic manipulation on the OXTPVN→BnST circuit proves ineffective in BTBR mice. Accordingly, chemogenetic activation of OXTPVN neurons that stimulate both OXT circuits induces OXT receptor expressions in both MeA and BnST as with those by social encounter in B6 mice. The induction of OXT receptor genes in the BnST was not observed in BTBR mice. These data support the hypothesis that OXT circuits serve as a regulator for OXT signaling in PVN to control socio-emotional approach/avoidance behavior, and a defect of OXTPVN→BnST circuit contributes to autism-like social phenotypes in BTBR mice.