bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on incidence of lamb morbidity and mortality and associated risk factors in the mixed crop-livestock production system of Gewata District, Kaffa zone, southwestern Ethiopia
Authors: Fesseha Haben , Gebremichael Gizaw , Asefa Isayas , Edaso Teshita 
Published: April 2023

AbstractLamb morbidity and mortality cause significant loss in a smallholder production system. A longitudinal prospective survey was conducted on 408 randomly selected farmers located in six purposefully selected kebeles in Gewata woreda from June 2020 to July 2021 to determine the incidence of morbidity and mortality in lambs and to identify risk factors. For this purpose, 408 lambs from the Gewata district’s mixed crop-livestock production system were examined every day from birth to three months of age. The data was analyzed using the Kaplan-Meier (K-M) method, the log-rank test, and Cox proportional hazards regression. Results showed that the cumulative incidence of all-cause of morbidity and mortality at the end of three month was 12.86% (95% CI: 10.26–16.13%), and 6.86% (95% CI: 5.03–9.35%), respectively. Diarrhea was the leading cause of morbidity and mortality, accounting for 49.33 and 50% morbidity and mortality, respectively. Pneumonia was the second most frequent cause of morbidity and death. In the K-M hazard analysis, the greatest risk of lamb morbidity and mortality was observed during the first month of life, and then the risk decreased significantly as the lamb grew. Of the 17 potential risk factors studied, the multivariable Cox proportional hazards regression model showed that lamb sex, birth weight, umbilical care, time and method of colostrum feeding were the five predictors that were significantly associated with a higher risk of morbidity, whereas birth weight, lambing difficulty, dams’ parity, method and time of colostrum feeding were the five predictors that were significantly associated with a higher risk of mortality. Moreover, a higher risk of morbidity was observed in lambs with methods of colostrum feeding after birth (HR = 3.158; p = 0.000) and with variations in birth weight (HR = 1.418; p = 0.003). Similarly, the mortality risk was 4.926 (p = 0.047), 4.023 (p = 0.012), and 3.206 (p = 0.000) times higher in lambs with lambing difficulties, at the time of colostrum feeding, and by the method of colostrum feeding, respectively. According to this research, lamb morbidity and mortality rates in the study area are significantly high which has a great impact on the replacement stock and production. Hence, awareness should be created among farmers concerning improved lamb management practices.
Fertility Preservation Decisional Turning Points for Adolescents and Young Adults With Cancer: Exploring Alignment and Divergence by Race and Ethnicity
Authors: Canzona Mollie R. , Murphy Karly , Victorson David , Harry Onengiya , Clayman Marla L. , McLean Thomas W. , Golden Shannon L. , Patel Bonnie , Strom Carla , Little-Greene Denisha , Saker Siba , Salsman John M. 
Published: April 2023

PURPOSEFor adolescents and young adults (AYAs) with cancer, fertility preservation (FP) decision making is complex and distressing. Racial/ethnic minority (REM) AYAs experience disparities in FP awareness, uptake, and outcomes. A turning point (TP) is a point of reflection, change, or decisive moment(s) resulting in changes in perspectives or trajectories. To enhance understanding of AYAs' diverse experiences, this study examined alignment and/or divergence of FP decisional TPs among non-Hispanic White (NHW) AYAs and REM AYAs.METHODSQualitative semistructured interviews were conducted in person, by video, or phone with 36 AYAs (20 NHW and 16 REM [nine Hispanic and seven Black/multiracial Black). The constant comparative method was used to identify and analyze themes illustrating participants' conceptualization and/or experience of FP decisional TPs.RESULTSSeven thematic TPs emerged: (1) emotional reaction to discovering FP procedures exist; (2) encountering unclear or dismissive communication during initial fertility conversations with health care providers; (3) encountering direct and supportive communication during initial fertility conversations with health care providers; (4) participating in critical family conversations about pursuing FP; (5) weighing personal desire for a child against other priorities/circumstances; (6) realizing FP is not feasible, and (7) experiencing unanticipated changes in cancer diagnosis or treatment plans/procedures. TP variations include REM participants reported dismissive communication and suggested cost was prohibitive. NHW participants emphasized more forcefully that biological children may become a future priority.CONCLUSIONUnderstanding how clinical communication and priorities/resources may vary for NHW and REM AYAs can inform future interventions aimed at reducing health disparities and enhancing patient-centered care.
Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial
Authors: Bandyopadhyay Anjishnujit , Kumar Pankaj , Jafra Anudeep , Thakur Haneesh , Yaddanapudi Laxmi Narayana , Jain Kajal 
Published: April 2023

BACKGROUND:
Critically injured patients who are agitated and delirious on arrival do not allow optimal preoxygenation in the emergency area. We investigated whether the administration of intravenous (IV) ketamine 3 minutes before administration of a muscle relaxant is associated with better oxygen saturation levels while intubating these patients.

METHODS:
Two hundred critically injured patients who required definitive airway management on arrival were recruited. The subjects were randomized as delayed sequence intubation (group DSI) or rapid sequence intubation (group RSI). In group DSI, patients received a dissociative dose of ketamine followed by 3 minutes of preoxygenation and paralysis using IV succinylcholine for intubation. In group RSI, a 3-minute preoxygenation was performed before induction and paralysis using the same drugs, as described conventionally. The primary outcome was incidence of peri-intubation hypoxia. Secondary outcomes were first-attempt success rate, use of adjuncts, airway injuries, and hemodynamic parameters.

RESULTS:
Peri-intubation hypoxia was significantly lower in group DSI (8 [8%]) compared to group RSI (35 [35%]; P = .001). First-attempt success rate was higher in group DSI (83% vs 69%; P = .02). A significant improvement in mean oxygen saturation levels from baseline values was seen in group DSI only. There was no incidence of hemodynamic instability. There was no statistically significant difference in airway-related adverse events.

CONCLUSIONS:
DSI appears promising in critically injured trauma patients who do not allow adequate preoxygenation due to agitation and delirium and require definitive airway on arrival.
In Vitro Analysis of Platelet Adhesion, Aggregation, and Surface GP1bα Expression in Stored Refrigerated Whole Blood: A Pilot Study
Authors: Keneally Ryan J. , Gonzalez-Almada Alberto , Wargowsky Richard , Fernandez Xiomara , Kochar Olga , Cresswell Gregory , Sarani Babak , Tanaka Kenichi , Mazzeffi Michael A. 
Published: April 2023

BACKGROUND:
Warm, fresh whole blood (WB) has been used by the US military to treat casualties in Iraq and Afghanistan. Based on data in that setting, cold-stored WB has been used to treat hemorrhagic shock and severe bleeding in civilian trauma patients in the United States. In an exploratory study, we performed serial measurements of WB’s composition and platelet function during cold storage. Our hypothesis was that in vitro platelet adhesion and aggregation would decrease over time.

METHODS:
WB samples were analyzed on storage days 5, 12, and 19. Hemoglobin, platelet count, blood gas parameters (pH, Po
2, Pco
2, and Spo
2), and lactate were measured at each timepoint. Platelet adhesion and aggregation under high shear were assessed with a platelet function analyzer. Platelet aggregation under low shear was assessed using a lumi-aggregometer. Platelet activation was assessed by measuring dense granule release in response to high-dose thrombin. Platelet GP1bα levels were measured with flow cytometry, as a surrogate for adhesive capacity. Results at the 3 study timepoints were compared using repeat measures analysis of variance and post hoc Tukey tests.

RESULTS:
Measurable platelet count decreased from a mean of (163 + 53) × 109 platelets per liter at timepoint 1 to (107 + 32) × 109 at timepoint 3 (P = .02). Mean closure time on the platelet function analyzer (PFA)-100 adenosine diphosphate (ADP)/collagen test increased from 208.7 + 91.5 seconds at timepoint 1 to 390.0 + 148.3 at timepoint 3 (P = .04). Mean peak granule release in response to thrombin decreased significantly from 0.7 + 0.3 nmol at timepoint 1 to 0.4 + 0.3 at timepoint 3 (P = .05). Mean GP1bα surface expression decreased from 232,552.8 + 32,887.0 relative fluorescence units at timepoint 1 to 95,133.3 + 20,759.2 at timepoint 3 (P < .001).

CONCLUSIONS:
Our study demonstrated significant decreases in measurable platelet count, platelet adhesion, and aggregation under high shear, platelet activation, and surface GP1bα expression between cold-storage days 5 and 19. Further studies are needed to understand the significance of our findings and to what degree in vivo platelet function recovers after WB transfusion.
Association Between Profound Shock Signs and Peripheral Intravenous Access Success Rates in Trauma Patients in the Prehospital Scenario: A Retrospective Study
Authors: Barsky Daniel , Radomislensky Irina , Talmy Tomer , Gendler Sami , Almog Ofer , Avital Guy 
Published: April 2023

BACKGROUND:
Hemorrhage is the leading cause of preventable death in trauma patients, and establishment of intravenous (IV) access is essential for volume resuscitation, a key component in the treatment of hemorrhagic shock. IV access among patients in shock is generally considered more challenging, although data to support this notion are lacking.

METHODS:
In this retrospective registry-based study, data were collected from the Israeli Defense Forces Trauma Registry (IDF-TR) regarding all prehospital trauma patients treated by IDF medical forces between January 2020 and April 2022, for whom IV access was attempted. Patients younger than 16 years, nonurgent patients, and patients with no detectable heart rate or blood pressure were excluded. Profound shock was defined as a heart rate >130 or a systolic blood pressure <90 mm Hg, and comparisons were made between patients with profound shock and those not exhibiting such signs. The primary outcome was the number of attempts required for first IV access success, which was regarded as an ordinal categorical variable: 1, 2, 3 and higher and ultimate failure. A multivariable ordinal logistic regression was performed to adjust for potential confounders. Patients’ sex, age, mechanism of injury and best consciousness level, as well as type of event (military/nonmilitary), and the presence of multiple patients were included in the ordinal logistic regression multivariable analysis model based on previous publications.

RESULTS:
Five hundred thirty-seven patients were included, 15.7% of whom were recorded as having signs of profound shock. Peripheral IV access establishment first attempt success rates were higher in the nonshock group, and there was a lower rate of unsuccessful attempts in this group (80.8% vs 67.8% for the first attempt, 9.4% vs 16.7% for the second attempt, 3.8% vs 5.6% for the third and further attempts, and 6% vs 10% unsuccessful attempts, P = .04). In the univariable analysis, profound shock was associated with requirement for an increased number of IV attempts (odds ratio [OR], 1.94; confidence interval [CI], 1.17–3.15). The ordinal logistic regression multivariable analysis demonstrated that profound shock was associated with worse results regarding primary outcome (adjusted odds ratio [AOR], 1.84; CI, 1.07–3.10).

CONCLUSIONS:
The presence of profound shock in trauma patients in the prehospital scenario is associated with an increased number of attempts required for IV access establishment.
Factor VIII: A Dynamic Modulator of Hemostasis and Thrombosis in Trauma
Authors: Tanaka Kenichi A. , Terada Rui , Butt Amir L. , Mazzeffi Michael A. , McNeil John S. 
Published: April 2023

A trace amount of thrombin cleaves factor VIII (FVIII) into an active form (FVIIIa), which catalyzes FIXa-mediated activation of FX on the activated platelet surface. FVIII rapidly binds to von Willebrand factor (VWF) after secretion and becomes highly concentrated via VWF-platelet interaction at a site of endothelial inflammation or injury. Circulating levels of FVIII and VWF are influenced by age, blood type (nontype O > type O), and metabolic syndromes. In the latter, hypercoagulability is associated with chronic inflammation (known as thrombo-inflammation).
In acute stress including trauma, releasable pools of FVIII/VWF are secreted from the Weibel-Palade bodies in the endothelium and then augment local platelet accumulation, thrombin generation, and leukocyte recruitment. Early systemic increases of FVIII/VWF (>200% of normal) levels in trauma result in a lower sensitivity of contact-activated clotting time (activated partial thromboplastin time [aPTT] or viscoelastic coagulation test [VCT]). However, in severely injured patients, multiple serine proteases (FXa plasmin and activated protein C [APC]) are locally activated and may be systemically released. Severity of traumatic injury correlates with prolonged aPTT and elevated activation markers of FXa, plasmin, and APC, culminating in a poor prognosis. In a subset of acute trauma patients, cryoprecipitate that contains fibrinogen, FVIII/VWF, and FXIII is theoretically advantageous over purified fibrinogen concentrate to promote stable clot formation, but comparative efficacy data are lacking. In chronic inflammation or subacute phase of trauma, elevated FVIII/VWF contributes to the pathogenesis of venous thrombosis by enhancing not only thrombin generation but also augmenting inflammatory functions.
Future developments in coagulation monitoring specific to trauma patients, and targeted to enhancement or inhibition of FVIII/VWF, are likely to help clinicians gain better control of hemostasis and thromboprophylaxis. The main goal of this narrative is to review the physiological functions and regulations of FVIII and implications of FVIII in coagulation monitoring and thromboembolic complications in major trauma patients.
Is Fetal-Type Posterior Cerebral Artery a Risk Factor for Recurrence in Coiled Internal Carotid Artery–Incorporating Posterior Communicating Artery Aneurysms? Analysis of Conventional Statistics, Computational Fluid Dynamics, and Random Forest With Hyper-Ensemble Approach
Authors: Chung Jaewoo , Cheong Jin Hwan , Kim Jae Min , Lee Deok Hee , Yi Hyeong-Joong , Choi Kyu-Sun , Ahn Jae Sung , Park Jung Cheol , Park Wonhyoung 
Published: April 2023

BACKGROUND:
The fetal-type posterior cerebral artery (FPCA) has been regarded as the risk factor for recurrence in coiled internal carotid artery–incorporating posterior communicating artery (ICA-PCoA) aneurysm. However, it has not been proven in previous literature studies.

OBJECTIVE:
To reveal the impact of FPCA on the recurrence of ICA-PCoA aneurysms using conventional statistical analysis, computational fluid dynamics (CFD) simulation, and random forest with hyper-ensemble approach (RF with HEA).

METHODS:
Vascular parameters and clinical information from patients who underwent coil embolization ICA-PCoA aneurysms from January 2011 to December 2016 were obtained. Conventional statistical analysis was applied to a total of 95 cases obtained from patients with a follow-up of more than 6 months. For CFD simulation, 3 sets of three-dimensional models were used to understand the hemodynamical characteristics of various FPCAs. The RF with HEA was applied to reinforce the clinical data analysis.

RESULTS:
The conventional statistical analysis fails to reveal that FPCA is a risk factor. CFD analysis shows that the diameter of FPCA alone is less likely to be a risk factor. The RF with HEA shows that the impact of FPCA is also minor compared with that of the packing density in the recurrence of coiled ICA-PCoA aneurysms.

CONCLUSION:
The gathered results of all 3 analyses show more clear evidence that FPCA is not a risk factor for coiled ICA-PCoA aneurysms. Hence, we may conclude that FPCA itself is doubtful to be the major risk factor in the recurrence of coiled ICA-PCoA aneurysms.
Recent Advances in Nanocarbon-Based Nonprecious Metal Catalysts for Oxygen/Hydrogen Reduction/Evolution Reactions and Zn-Air Battery
Authors: Ganesan Pandian , Ishihara Akimitsu , Staykov Aleksandar , Nakashima Naotoshi 
Published: April 2023

Abstract
In this review article, we focus on the design and creation of earth-abundant non-precious metal-coordinated eco-friendly catalysts with high oxygen reduction reaction (ORR), oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) performances. The development of a cost-effective, efficient and durable bifunctional ORR and OER electrochemical catalyst is a key for future batteries. So far, precious metals, such as Pt and Ir, have been used as efficient catalysts for the ORR and OER, respectively. However, they are expensive and their deposits on earth are limited, which are the major drawbacks of these metals. One more drawback for the practical application is the sluggish reactions of ORR and OER. Since electroconductivity of promising metal-free catalyst candidates are poor, good electronic supporting materials are needed. Owing to the high conductivity, stability and easy handling, carbon nanotubes are a most promising material. After Introduction, we summarize recent advances in i) carbon nanotube/nanocarbon-based ORR and OER catalysts, ii) metal oxide and others/nanocarbon catalysts for ORR, OER, HER and Zn-air electrodes, as well as iii) computational study for such catalyst reactions. Such studies are highly beneficial for future energy materials design and synthesis in batteries and molecular catalysts with high performances.
Epidemiology of Dog Walking–Related Injuries among Adults Presenting to US Emergency Departments, 2001–2020
Authors: MAXSON RIDGE , LELAND CHRISTOPHER R. , MCFARLAND EDWARD G. , LU JIM , MESHRAM PRASHANT , JONES VANYA C. 
Published: April 2023

ABSTRACT

Purpose
Dog walking is a popular daily activity, yet information regarding its injury burden is limited. This study describes the epidemiology of injuries related to leash-dependent dog walking among adults presenting to US emergency departments from 2001 to 2020.

Methods
A retrospective analysis was performed using the National Electronic Injury Surveillance System database to identify adults (≥18 yr) presenting to US emergency departments with leash-dependent dog walking–related injuries between 2001 and 2020. Outcomes included annual estimates of injury incidence, injury characteristics, and risk factors for sustaining a fracture or traumatic brain injury (TBI). Weighted estimates and 95% confidence intervals (CI) were generated using National Electronic Injury Surveillance System sample weights.

Results
Between 2001 and 2020, an estimated 422,659 adults presented to US emergency departments with injuries related to leash-dependent dog walking. The annual incidence increased more than fourfold during this period (n = 7282 vs n = 32,306, P < 0.001). Most patients were women (75%) and adults age 40 to 64 yr (47%), with a mean age of 53 ± 0.5 yr. Patients commonly injured their upper extremity (51%) and were injured while falling when pulled or tripped by the leash (55%). The three most common injuries were finger fracture (6.9%), TBI (5.6%), and shoulder sprain/strain (5.1%). On multivariate analysis, fracture risk among dog walkers was higher in adults age ≥65 yr (odds ratio [OR], 2.1; 95% CI, 1.8–2.5) and women (OR, 1.5; 95% CI, 1.3–1.7). Risk of TBI was also elevated among older dog walkers (OR, 1.6; 95% CI, 1.3–2.0).

Conclusions
Dog walking is associated with a considerable and rising injury burden. Dog owners should be informed of this injury potential and advised on risk-reduction strategies.
Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children
Authors: Wilson Kyle J , Tu Zhanhan , Mbale Emmie , Mhango Priscilla P , Kayange Petros , Gladstone Melissa J. , Harding Simon , Gottlob Irene , Garcia-Finana Marta , Shen Yaochun , Taylor Terrie E , Seydel Karl B , Zheng Yalin , Beare Nicholas AV 
Published: April 2023

Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of death in paediatric CM is brain swelling. Long term morbidity is typically characterised by neurological and neurodevelopmental sequelae. Optical coherence tomography can be used to quantify papilloedema and macular ischaemia, identified as hyperreflectivity. Here we describe a protocol to test the hypotheses that quantification of optic nerve head swelling using optical coherence tomography can identify severe brain swelling in CM, and that quantification of hyperreflectivity in the macula predicts neurodevelopmental outcomes post-recovery. Additionally, our protocol includes the development of a novel, low-cost, handheld optical coherence tomography machine and artificial intelligence tools to assist in image analysis.
Mental health awareness in early years
Authors: Webster Chloe 
Published: April 2023

Do you have something to share, reflect on or provoke thinking around? Write to the editor: elly.roberts@markallengroup.com Early years practitioner, Chloe Webster, shares her thoughts on the importance of staff understanding the relationship between the mental health needs of their colleagues and those of the children in their care, for Mental Health Awareness Month in May.
Transforming play
Authors: Grimmer Tamsin 
Published: April 2023

Early years consultant and trainer, Tamsin Grimmer, discusses ways to encourage different types of transforming play, allowing children to explore and build an understanding of scientific concepts and processes at an early age. Transforming – children like to explore and see changes, e.g. adding colour to cornflour, mixing paints together, making or manipulating play dough, adding juice to food to see what happens, adding water to sand and/or making sand moulds.