bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-factor H antibody-positive C3 glomerulonephritis secondary to poststreptococcal acute glomerulonephritis with diabetic nephropathy
Authors: Oba Yuki , Mizuno Hiroki , Taneda Sekiko , Sawai Toshihiro , Oda Takashi , Ikuma Daisuke , Yamanouchi Masayuki , Suwabe Tatsuya , Kono Kei , Kinowaki Keiichi , Ohashi Kenichi , Sawa Naoki , Ubara Yoshifumi 
Published: July 2023

AbstractPoststreptococcal acute kidney glomerulonephritis (PSAGN) has been seen in adults in recent years, especially in patients with type 2 diabetes mellitus, and the renal prognosis has not always been good. There have been cases of PSAGN in which complete remission was not achieved and hematuria and proteinuria persisted, leading to end-stage renal disease. Previous reports showed that the patients subjected to PSAGN have an underlying defect in regulating the alternative pathway of complement, and they identified that antibodies to the C3 convertase, C3 nephritic factors (C3NeF), are involved. C3NeF stabilizes C3 convertase, sustains C3 activation, and causes C3 glomerulonephritis (C3GN). On the other hand, factor H is a glycoprotein that suppresses the overactivation of the alternative pathway by decaying the C3 convertase. Anti-factor H (aFH) antibodies interfere with factor H and cause the same activation of the alternative pathway as C3NeF. However, a limited number of reports describe the clinical course of C3GN with aFH antibodies. We encountered a 49-year-old Japanese man with type 2 diabetes mellitus. He was referred to our hospital because of his elevated serum creatinine, proteinuria, hematuria, and developed edema on both legs. He was diagnosed as PSAGN at the first kidney biopsy, and his renal function improved and edema and hematuria disappeared, but proteinuria persisted after 5 months. He was diagnosed as C3GN at the second kidney biopsy. In our case, no C3NeF was detected. However, a high titer of aFH antibodies was detected in stored serum from the initial presentation, providing a unified diagnosis of aFH antibody-positive C3GN secondary to PSAGN. He progressed to end-stage renal disease (ESRD) and hemodialysis was started. The persistence of high levels of aFH autoantibodies may have caused C3GN secondary to PSAGN due to activating the alternative complement pathway, which eventually worsened the nephropathy and led to ESRD.
Human Endometrium Derived Induced Pluripotent Stem Cells Are Amenable to Directed Erythroid Differentiation
Authors: Kim Hyun Kyung , Cho SiHyun , Choi Young Sik , Lee Byung Seok , Kim Sinyoung , Kim Hyun Ok , Park Joo Hyun 
Published: July 2023

Abstract
BACKGROUND:
A protocol for using human endometrium derived induced pluripotent stem cells (iPSCs) to derive hematopoietic and erythroid lineages will be elaborated, through a two-phase culture system.

METHODS:
Discarded endometrial tissues were obtained from women receiving hysterectomy in their 4th to 5th decade due to benign uterine conditions. pCE-Sox2, Oct4, Klf4, L-Myc and Lin28 episomal vectors were used to electrotransfect the endometrial stromal cells. The first 8 days involves commitment to hematopoietic stem cells through embryoid body with robust expansion on murine bone marrow stromal cells. The second phase involves feeder free conditions with hydrocortisone, stem cell factor, interleukin-3, and recombinant EPO. After 22 days of feeder free culture, the expression profiles of CD235a+, CD34+, CD43+ and CD 71+ were analyzed by flow cytometry and Wright-Giemsa staining for differential counting. The oxygen carrying capacity of cultured RBCs was measured using a hemoxanalyser.

RESULTS:
As a result of inducing these cells via co-culture with murine stromal fibroblasts, all endometrium derived iPSCs were differentiated into erythroblasts with a stable yield of approximately 80% for polychromatic and orthochromatic normoblasts. The protocol for complete induction of erythroid lineage cells starting from human endometrial tissue via iPS cells has been optimized.

CONCLUSION:
Successful directed erythroid differentiation has occurred from human endometrium-derived iPS cells. A comprehensive process of actually deriving iPS cells using discarded surgical hysterectomy specimens to the erythroid fate has significance in that the scope of using human iPSC cell lines for tissue regeneration could be expanded in the future.
Application of Liquefied Wood Products for Particleboard Manufacturing: a Meta-analysis Review
Authors: Janiszewska-Latterini Dominika , Pizzi Antonio 
Published: July 2023

AbstractPurpose of ReviewThe development of eco-friendly panels is one of the major issues for the wood industry, particularly in terms of developing new adhesive systems for reducing harmful emissions and dependence from fossil fuel resources. Among the plethora of various possible solutions, liquefied wood products have demonstrated promising features to decrease the use of petroleum-based amino resins. A meta-analysis was carried out to develop a quantitative synthesis of the state of the art of the application of liquefied wood products for particleboard manufacturing, investigating their effects on the board’s properties.Recent FindingsThe results from meta-analysis revealed that the application of liquefied wood products does not significantly deteriorate the mechanical properties of particleboards. It has also been observed that there is no negative influence on the formaldehyde content of the panel, mostly when liquefied wood products are applied in mixture with commercial resin. The most interesting observation is that the performance of the boards was not affected by the type of feedstock used for liquefaction.SummaryThe option to apply liquefied wood products has the potential to significantly decrease the application of commercial formaldehyde-based resins without leading to a deterioration of the properties of the panels. It is however important to note that there is currently a limited number of studies on this topic. The meta-analysis showed a notable variability of the effect sizes in the trials. Further study is needed to determine the outcomes and the benefits for the use of liquefied wood products on an industrial level.
European position paper on polypharmacy and fall-risk-increasing drugs recommendations in the World Guidelines for Falls Prevention and Management: implications and implementation
Authors: van der Velde Nathalie , Seppala Lotta J. , Hartikainen Sirpa , Kamkar Nellie , Mallet Louise , Masud Tahir , Montero-Odasso Manuel , van Poelgeest Eveline P. , Thomsen Katja , Ryg Jesper , Petrovic Mirko ,   The EuGMS Task, Finish Group on Fall-risk-increasing drugs
Published: July 2023

AbstractFalls prevention and management in older adults is a critical global challenge. One of the key risk factors for falls is the use of certain medications. Therefore, to prevent medication-related falls, the following is recommended in the recent World Guidelines for Falls Prevention and Management: (1) assess for fall history and the risk of falls before prescribing potential fall-risk-increasing drugs (FRIDs), (2) use a validated, structured screening and assessment tool to identify FRIDs when performing a medication review, (3) include medication review and appropriate deprescribing of FRIDs as a part of the multifactorial falls prevention intervention, and (4) in long-term care residents, if multifactorial intervention cannot be conducted due to limited resources, the falls prevention strategy should still always include deprescribing of FRIDs.In the present statement paper, the working group on medication-related falls of the World Guidelines for Falls Prevention and Management, in collaboration with the European Geriatric Medicine Society (EuGMS) Task and Finish group on FRIDs, outlines its position on how to implement and execute these recommendations in clinical practice.Preferably, the medication review should be conducted as part of a comprehensive geriatric assessment to produce a personalized and patient-centered assessment. Furthermore, the major pitfall of the published intervention studies so far is the suboptimal implementation of medication review and deprescribing. For the future, it is important to focus on gaining which elements determine successful implementation and apply the concepts of implementation science to decrease the gap between research and practice.
No cause for collapse
Authors: Gooßens Dustin , Tedder Andrew 
Published: July 2023

AbstractWe investigate a hitherto under-considered avenue of response for the logical pluralist to collapse worries. In particular, we note that standard forms of the collapse arguments seem to require significant order-theoretic assumptions, namely that the collection of admissible logics for the pluralist should be closed under meets and joins. We consider some reasons for rejecting this assumption, noting some prima facie plausible constraints on the class of admissible logics which would lead a pluralist admitting those logics to resist such closure conditions.
Investigation of Facilitating English Speaking of Elementary School Students in Authentic Contexts with UEnglish
Authors: Zhao Xiang-Jun , Hwang Wu-Yuin , Hoang Anh , Su Yun-Chi 
Published: July 2023

AbstractDespite the importance of English in various aspects of life, students learning English as a foreign language often lack sufficient opportunities to practice speaking in their daily lives. To address these issues, this study proposes an innovative mobile app called Ubiquitous English (UEnglish) that facilitates English speaking learning in authentic contexts anytime and anywhere. Leveraging advanced technologies, UEnglish incorporates automatic speech recognition (ASR), cloud machine translation (MT), and text-to-speech (TTS) functionalities. The primary aim of this study is to assess the impact of UEnglish on students’ English speaking ability, specifically focusing on the quality and quantity of their spoken English when describing comic pictures and authentic pictures. To investigate the learning behaviors and the influence on English speaking learning achievement in this study, 56 fifth-grade students were employed, including 28 students in an experimental group (EG) using UEnglish and 28 students in a control group (CG) with a paper-based teaching method. The results indicated that, after the experiment, EG outperformed CG and EG had significant differences in the quality and quantity of English speaking in the context of describing comic pictures and authentic pictures. Students’ learning portfolios revealed that EG students not only could use more English words and more complex sentences to express their thoughts but also easily applied what they learned when encountering similar contexts. Our findings suggested that authentic contextual English learning with UEnglish was helpful for students to practice speaking English related to their surroundings.
Kinematics and Convergent Tectonics of the Northwestern South American Plate During the Cenozoic
Authors: González R. , Oncken O. , Faccenna C. , Le Breton E. , Bezada M. , Mora A. 
Published: July 2023

AbstractThe interaction of the northern Nazca and southwestern Caribbean oceanic plates with northwestern South America (NWSA) and the collision of the Panama‐Choco arc (PCA) have significant implications on the evolution of the northern Andes. Based on a quantitative kinematic reconstruction of the Caribbean and Farallon/Farallon‐derived plates, we reconstructed the subducting geometries beneath NWSA and the PCA accretion to the continent. The persistent northeastward migration of the Caribbean plate relative to NWSA in Cenozoic time caused the continuous northward advance of the Farallon‐Caribbean plate boundary, which in turn resulted in its progressive concave trench bending against NWSA. The increasing complexity during the Paleogene included the onset of Caribbean shallow subduction, the PCA approaching the continent, and the forced shallow Farallon subduction that ended in the fragmentation of the Farallon Plate into the Nazca and Cocos plates and the Coiba and Malpelo microplates by the late Oligocene. The convergence tectonics after late Oligocene comprised the accretional process of the PCA to NWSA, which evolved from subduction erosion of the forearc to collisional tectonics by the middle Miocene, as well as changes of convergence angle and slab dip of the Farallon‐derived plates, and the attachment of the Coiba and Malpelo microplates to the Nazca plate around 9 Ma, resulting in a change of convergence directions. During the Pliocene, the Nazca slab broke at 5.5°N, shaping the modern configuration. Overall, the proposed reconstruction is supported by geophysical data and is well correlated with the magmatic and deformation history of the northern Andes.
Referencing of Continental‐Scale InSAR‐Derived Velocity Fields: Case Study of the Eastern Tibetan Plateau
Authors: Lemrabet Laëtitia , Doin Marie‐Pierre , Lasserre Cécile , Durand Philippe 
Published: July 2023

AbstractThe wealth of Sentinel‐1 data in eastern Tibet allows to discuss whether InSAR‐derived velocity maps measure ground motion in the ITRF reference frame with sufficient accuracy for large‐scale tectonic applications. High elevation, moderate relief and low vegetation cover in eastern Tibet ensure reliable multi‐temporal InSAR results. We automatically process seven 1,200 km long ascending and descending orbits, divided into 2 or 3 overlapping segments along‐track. Linear phase ramps in range and azimuth are removed from interferograms. The ramps and the flattened interferograms are separately inverted into time series and analyzed. The ramps are modeled by their Solid Earth Tides (SET) contribution, seasonal variations, and a trend in time. SET oscillations are clearly visible in the ramp time series. Seasonal tidal amplifications of probable atmospheric origin are also evidenced. Ramp rates are shown to precisely quantify the plate motion of each segment in the ITRF reference frame. They are thus added back to the velocity maps before along‐track merging. Then, a simple referencing procedure implying only a constant and a tilt in azimuth adjusted for each track is constrained by horizontal GNSS data. It allows straightforward vertical and horizontal decomposition. The quality of the merged and referenced data sets can then be quantitatively assessed at 1 mm/yr by the differences between InSAR and GNSS velocities and by the InSAR residuals on track overlaps. The vertical velocity field is dominated at first order by the effect of permafrost degradation, while the horizontal velocity highlights strain accumulation across major strike‐slip faults in eastern Tibet.
Debris‐Flow Process Controls on Steepland Morphology in the San Gabriel Mountains, California
Authors: Struble William T. , McGuire Luke A. , McCoy Scott W. , Barnhart Katherine R. , Marc Odin 
Published: July 2023

AbstractSteep landscapes evolve largely by debris flows, in addition to fluvial and hillslope processes. Abundant field observations document that debris flows incise valley bottoms and transport substantial sediment volumes, yet their contributions to steepland morphology remain uncertain. This has, in turn, limited the development of debris‐flow incision rate formulations that produce morphology consistent with natural landscapes. In many landscapes, including the San Gabriel Mountains (SGM), California, steady‐state fluvial channel longitudinal profiles are concave‐up and exhibit a power‐law relationship between channel slope and drainage area. At low drainage areas, however, valley slopes become nearly constant. These topographic forms result in a characteristically curved slope‐area signature in log‐log space. Here, we use a one‐dimensional landform evolution model that incorporates debris‐flow erosion to reproduce the relationship between this curved slope‐area signature and erosion rate in the SGM. Topographic analysis indicates that the drainage area at which steepland valleys transition to fluvial channels correlates with measured erosion rates in the SGM, and our model results reproduce these relationships. Further, the model only produces realistic valley profiles when parameters that dictate the relationship between debris‐flow erosion, valley‐bottom slope, and debris‐flow depth are within a narrow range. This result helps place constraints on the mathematical form of a debris‐flow incision law. Finally, modeled fluvial incision outpaces debris‐flow erosion at drainage areas less than those at which valleys morphologically transition from near‐invariant slopes to concave profiles. This result emphasizes the critical role of debris‐flow incision for setting steepland form, even as fluvial incision becomes the dominant incisional process.
Hyperspectral Mixture Models in the CHIME Mission Implementation for Topsoil Texture Retrieval
Authors: Valentini Emiliana , Taramelli Andrea , Marinelli Chiara , Martin Laura Piedelobo , Fassari Marco , Troffa Stefano , Mzid Nada , Casa Raffaele , Pignatti Stefano 
Published: July 2023

AbstractThis study is part of the requirements consolidation study for the European Copernicus Hyperspectral Imaging Mission for Environment (CHIME). It explores the value added by existing hyperspectral data of similar characteristics to CHIME, namely AVIRIS‐NG and PRecursore IperSpettrale della Missione Applicativa (PRISMA), for detecting topsoil texture properties. The spatial variability is retrieved using the linear spectral mixture analysis, an image‐based algorithm that breaks down the hyperspectral data set into fractional abundance of spectral classes within each pixel. The fractional abundance of image‐based endmembers is broken into categories to find intervals having a spatial relation with texture components in terms of fine (clay and silt) or coarse (sand) abundance. The fraction maps obtained show similar spatial patterns to the USDA soil texture classification, obtained with a geostatistical approach. Specifically, AVIRIS CHIME‐like FAM1 > 0.45 presented an agreement of 86% with clay and/or silt higher than 45% which, according to the United Stated Agriculture Department (USDA) intervals, correspond to loam‐clay loam classes. Similar results are obtained with PRISMA with FAM2 0.20–0.35, overlapping 63% of the kriging‐based USDA clay‐loam class. The fractional abundance categories showing the highest overlap percentages are correlated with the short‐wave infrared spectral range, showing average coefficients of 0.7 where wavelengths are over 1,500 nm. From 1700 nm, CHIME‐like shows values of 0.8. In conclusion, this exploratory research and results leverage the opportunity of extending the processing chain to a larger number of case studies to better understand the physical relation between the spectral reflectance captured by new spaceborne hyperspectral sensors and the spatial patterns of soil texture classes.
Coral Sr‐U Thermometry Tracks Ocean Temperature and Reconciles Sr/Ca Discrepancies Caused by Rayleigh Fractionation
Authors: Galochkina M. , Cohen A. L. , Oppo D. W. , Mollica N. , Horton F. 
Published: July 2023

AbstractUnderstanding climate change at the spatiotemporal scales necessary to improve climate projections requires proxy records that complement sparse and often contradictory observational temperature data sets. Massive long‐lived corals have tremendous potential in this regard, continuously recording information about ocean conditions as they grow. Nevertheless, extracting accurate ocean temperatures from corals is challenging because factors other than temperature influence skeletal chemistry. Here, we tested the ability of the coral Sr‐U thermometer to accurately capture annual sea surface temperatures (SSTs) in the subtropical Atlantic, where year‐to‐year temperatures vary by ∼1°C. Using laser ablation inductively coupled plasma mass spectrometry (LA‐ICP‐MS), we generated sufficient U/Ca – Sr/Ca pairs from a slow‐growing (1−2 mm/yr) Siderastrea siderea coral to calculate annual Sr‐U values. With the fine‐scale spatial resolution attained using the laser, skeleton accreted during both fast and slow growing times of the year was represented in our sampling. The resulting 30‐year‐long Sr‐U record tracked the amplitude and timing of annual SST to within ±0.2°C of observations (r = −0.71), whereas the Sr/Ca record did not (r = 0.23). Furthermore, Sr‐U corrected for Sr/Ca offsets among adjacent skeletal elements approximately 1 mm apart. These offsets are equivalent to differences of 2–3°C if typical Sr/Ca–SST calibrations are applied. Our observations indicate that Sr‐U can accurately constrain decadal‐to‐multidecadal variability and secular SST trends in regions where this information is urgently needed.
Atmospheric Methane: Comparison Between Methane's Record in 2006–2022 and During Glacial Terminations
Authors: Nisbet Euan G. , Manning Martin R. , Dlugokencky Ed J. , Michel Sylvia Englund , Lan Xin , Röckmann Thomas , Denier van der Gon Hugo A. C. , Schmitt Jochen , Palmer Paul I. , Dyonisius Michael N. , Oh Youmi , Fisher Rebecca E. , Lowry David , France James L. , White James W. C. , Brailsford Gordon , Bromley Tony 
Published: July 2023

AbstractAtmospheric methane's rapid growth from late 2006 is unprecedented in the observational record. Assessment of atmospheric methane data attributes a large fraction of this atmospheric growth to increased natural emissions over the tropics, which appear to be responding to changes in anthropogenic climate forcing. Isotopically lighter measurements of are consistent with the recent atmospheric methane growth being mainly driven by an increase in emissions from microbial sources, particularly wetlands. The global methane budget is currently in disequilibrium and new inputs are as yet poorly quantified. Although microbial emissions from agriculture and waste sources have increased between 2006 and 2022 by perhaps 35 Tg/yr, with wide uncertainty, approximately another 35–45 Tg/yr of the recent net growth in methane emissions may have been driven by natural biogenic processes, especially wetland feedbacks to climate change. A model comparison shows that recent changes may be comparable or greater in scale and speed than methane's growth and isotopic shift during past glacial/interglacial termination events. It remains possible that methane's current growth is within the range of Holocene variability, but it is also possible that methane's recent growth and isotopic shift may indicate a large‐scale reorganization of the natural climate and biosphere is under way.
Tug‐Of‐War on Idealized Midlatitude Cyclones Between Radiative Heating From Low‐Level and High‐Level Clouds
Authors: Voigt Aiko , Keshtgar Behrooz , Butz Klara 
Published: July 2023

AbstractWe present baroclinic life‐cycle simulations with two versions of the atmosphere model ICON to understand how cloud‐radiative heating and cooling affect an idealized midlatitude cyclone. Both versions simulate the same cyclone when run without radiation, but disagree when cloud‐radiation‐interaction is taken into account. The radiative effects of clouds weaken the cyclone in ICON2.1 but strengthen it in ICON2.6. We attribute the disagreement to low‐level clouds, which in ICON2.1 are more abundant and show stronger radiative cooling of the boundary layer. We argue that radiative cooling from low‐level cloud tops weakens the cyclone by increasing boundary‐layer static stability, and that radiative cooling from high‐level cloud tops strengthens the cyclone by decreasing static stability in the upper troposphere and sharpening the tropopause. Our results indicate that clouds and the vertical distribution of their radiative heating and cooling can influence the dynamics of midlatitude cyclones.