bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram predictive model for long-term survival in spontaneous intracerebral hemorrhage patients without cerebral herniation at admission
Authors: Lin Fuxin , He Qiu , Zhuo Lingyun , Zhao Mingpei , Ye Gengzhao , Gao Zhuyu , Huang Wei , Cai Lveming , Wang Fangyu , Shangguan Huangcheng , Fang Wenhua , Lin Yuanxiang , Wang Dengliang , Kang Dezhi 
Published: February 2023

AbstractStratification of spontaneous intracerebral hemorrhage (sICH) patients without cerebral herniation at admission, to determine the subgroups may be suffered from poor outcomes or benefit from surgery, is important for following treatment decision. The aim of this study was to establish and verify a de novo nomogram predictive model for long-term survival in sICH patients without cerebral herniation at admission. This study recruited sICH patients from our prospectively maintained ICH patient database (RIS-MIS-ICH, ClinicalTrials.gov Identifier: NCT03862729) between January 2015 and October 2019. All eligible patients were randomly classified into a training cohort and a validation cohort according to the ratio of 7:3. The baseline variables and long-term survival outcomes were collected. And the long-term survival information of all the enrolled sICH patients, including the occurrence of death and overall survival. Follow-up time was defined as the time from the onset to death of the patient or the last clinical visit. The nomogram predictive model was established based on the independent risk factors at admission for long-term survival after hemorrhage. The concordance index (C-index) and ROC curve were used to evaluate the accuracy of the predictive model. Discrimination and calibration were used to validate the nomogram in both the training cohort and the validation cohort. A total of 692 eligible sICH patients were enrolled. During the average follow-up time of 41.77 ± 0.85 months, a total of 178 (25.7%) patients died. The Cox Proportional Hazard Models showed that age (HR 1.055, 95% CI 1.038–1.071, P < 0.001), Glasgow Coma Scale (GCS) at admission (HR 2.496, 95% CI 2.014–3.093, P < 0.001) and hydrocephalus caused by intraventricular hemorrhage (IVH) (HR 1.955, 95% CI 1.362–2.806, P < 0.001) were independent risk factors. The C index of the admission model was 0.76 and 0.78 in the training cohort and validation cohort, respectively. In the ROC analysis, the AUC was 0.80 (95% CI 0.75–0.85) in the training cohort and was 0.80 (95% CI 0.72–0.88) in the validation cohort. SICH patients with admission nomogram scores greater than 87.75 were at high risk of short survival time. For sICH patients without cerebral herniation at admission, our de novo nomogram model based on age, GCS and hydrocephalus on CT may be useful to stratify the long-term survival outcomes and provide suggestions for treatment decision-making.
Anomalous kinetic study of atenolol release from ATN@DNA a core-shell like structure
Authors: Hefny Mohamed Mokhtar , Elmezayyen Ayman S. , Tawfik Ashraf M. 
Published: February 2023

AbstractThe need for more efficient drug delivery strategies with ultraprecision and control over the release of drugs has led to the growth of more sophisticated drug-releasing systems as a promising alternative to conventional clinical therapies. This new seed of strategies has explored an encouraging property to overcome the inherent problems of traditional therapies. One of the major challenges for any drug delivery system is the introduction of a complete view of the delivery system. In this article, we intend to elucidate the theoretical proof of concept of the electrosynthesis ATN@DNA core-shell like structure as a model system. Therefore, we present a fractal kinetic model (non-exponential model) taking into consideration the concept of time-dependent diffusion coefficient, which was developed using a numerical method with the help of COMSOL Multiphysics. In addition to that, we present here a general fractional kinetic model in sense of the tempered fractional operator, which leads to better characterized memory properties of the release process. Also, the fractional model is compared with the fractal kinetic model and both offer a good description of drug release processes that present anomalous kinetics. The solutions of the fractal and fractional kinetic models are also fitted successfully with our real-release results.
Acquired radioresistance in EMT6 mouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 through JAK/STAT/PI3K pathway
Authors: Sham Nur Fatihah Ronny , Hasani Narimah Abdul Hamid , Hasan Nurhaslina , Karim Muhammad Khalis Abdul , Fuad Syed Baharom Syed Ahmad , Hasbullah Harissa Husainy , Ibahim Mohammad Johari 
Published: February 2023

AbstractCancer recurrence is often associated with the acquisition of radioresistance by cancer tissues due to failure in radiotherapy. The underlying mechanism leading to the development of acquired radioresistance in the EMT6 mouse mammary carcinoma cell line and the potential pathway involved was investigated by comparing differential gene expressions between parental and acquired radioresistance cells. EMT6 cell line was exposed to 2 Gy/per cycle of gamma-ray and the survival fraction between EMT6-treated and parental cells was compared. EMT6RR_MJI (acquired radioresistance) cells was developed after 8 cycles of fractionated irradiation. The development of EMT6RR_MJI cells was confirmed with further irradiation at different doses of gamma-ray, and both the survival fraction and migration rates were measured. Higher survival fraction and migration rates were obtained in EMT6RR_MJI cells after exposure to 4 Gy and 8 Gy gamma-ray irradiations compared to their parental cells. Gene expression between EMT6RR_MJI and parental cells was compared, and 16 genes identified to possess more than tenfold changes were selected and validated using RT-PCR. Out of these genes, 5 were significantly up-regulated i.e., IL-6, PDL-1, AXL, GAS6 and APCDD1. Based on pathway analysis software, the development of acquired radioresistance in EMT6RR_MJI was hypothesized through JAK/STAT/PI3K pathway. Presently, CTLA-4 and PD-1 were determined to be associated with JAK/STAT/PI3K pathway, where both their expressions were significantly increased in EMT6RR_MJI compared to parental cells in the 1st, 4th and 8th cycle of radiation. As a conclusion, the current findings provided a mechanistic platform for the development of acquired radioresistance in EMT6RR_MJI through overexpression of CTLA-4 and PD-1, and novel knowledge on therapeutic targets for recurrent radioresistant cancers.
Whistler waves generated inside magnetic dips in the young solar wind: Observations of the search-coil magnetometer on board Parker Solar Probe
Authors: Froment C. , Agapitov O. V. , Krasnoselskikh V. , Karbashewski S. , Dudok de Wit T. , Larosa A. , Colomban L. , Malaspina D. , Kretzschmar M. , Jagarlamudi V. K. , Bale S. D. , Bonnell J. W. , Mozer F. S. , Pulupa M. 
Published: February 2023

Context.Whistler waves are electromagnetic waves produced by electron-driven instabilities, which in turn can reshape the electron distributions via wave–particle interactions. In the solar wind they are one of the main candidates for explaining the scattering of the strahl electron population into the halo at increasing radial distances from the Sun and for subsequently regulating the solar wind heat flux. However, it is unclear what type of instability dominates to drive whistler waves in the solar wind.Aims.Our goal is to study whistler wave parameters in the young solar wind sampled by Parker Solar Probe (PSP). The wave normal angle (WNA) in particular is a key parameter to discriminate between the generation mechanisms of these waves.Methods.We analyzed the cross-spectral matrices of magnetic field fluctuations measured by the search-coil magnetometer (SCM) and processed by the Digital Fields Board (DFB) from the FIELDS suite during PSP’s first perihelion.Results.Among the 2701 wave packets detected in the cross-spectra, namely individual bins in time and frequency, most were quasi-parallel to the background magnetic field; however, a significant part (3%) of the observed waves had oblique (> 45°) WNA. The validation analysis conducted with the time series waveforms reveal that this percentage is a lower limit. Moreover, we find that about 64% of the whistler waves detected in the spectra are associated with at least one magnetic dip.Conclusions.We conclude that magnetic dips provide favorable conditions for the generation of whistler waves. We hypothesize that the whistlers detected in magnetic dips are locally generated by the thermal anisotropy as quasi-parallel and can gain obliqueness during their propagation. We finally discuss the implications of our results for the scattering of the strahl in the solar wind.
Apprendre en inter-professionnalité à partir de l’expérience de patients-mentors
Authors: Gross Olivia , Azogui-Levy Sylvie , Bourdon Olivier , Foucaut Aude-Marie , Margat Aurore , Lartigue Corinne , Lassale Saadia , Ruelle Yannick , Wagner Agathe , Gagnayre Rémi 
Published: February 2023

Contexte : Les curriculums informels et cachés ainsi que le paradigme positiviste expliquent en partie la baisse de l’empathie observée auprès des étudiants en santé. Ils génèrent aussi des injustices épistémiques qui s’exercent sur les patients mais aussi entre professionnels de santé. Un programme interprofessionnel mobilisant des patients-mentors a été mis en place dans le cadre de la formation initiale d’étudiants en santé pour améliorer cet état de fait. Objectif : Il s’agissait d’évaluer s’il permettait d’atteindre cet objectif et d’en caractériser les mécanismes explicatifs afin de repérer les ingrédients actifs du programme. Méthodes : Quarante-cinq étudiants en santé issus de six filières de formation différentes ont été réunis en petits groupes à quatre reprises avec un patient-mentor. L’étude qualitative a mêlé entretiens individuels et collectifs et réponses écrites à un questionnaire. Résultats et discussion : Ces rencontres ont opéré comme l’élément déclencheur à la base d’apprentissages transformationnels. Les étudiants ont pris conscience de certains de leurs préjugés et de leurs limites, ce qui devrait favoriser des relations plus horizontales avec les patients et avec les autres professionnels de santé. L’autogestion des groupes, le fait que le nombre de participants à ces groupes soit relativement réduit, les rencontres multiples avec un patient en dehors des soins, les thèmes de discussion suggérés, ont permis l’actualisation des mécanismes d’apprentissages. Ces derniers renvoient à la décentration, à l’humilité, au non-jugement et à la proximité qui se sont actualisés dans ces groupes. Le développement de pensées autonomes et la prise en compte de leurs propres ressentis peuvent être vus comme des effets intermédiaires. Les effets finaux portent sur l’élaboration de savoirs incarnés au niveau de l’approche centrée sur le patient et sur un sens de responsabilité accru. Ces deux dimensions se manifestent par de nouvelles résolutions et de nouvelles pratiques professionnelles. Conclusion : L’étude permet d’expliquer les processus d’apprentissages des étudiants dans le cadre des programmes de cet ordre. Mais aussi, elle témoigne du fait que des apprentissages transformationnels sont encore possibles à ce stade de leurs études.
Création d’un groupe de patients simulés bénévoles : un atout pour la formation et l’évaluation à l’heure de la réforme du deuxième cycle des études médicales en France
Authors: Bellot Anne , Albert Christine , Ristovski Maud , Dolley Patricia , Guillois Bernard 
Published: February 2023

Contexte : La simulation s’impose aujourd’hui comme l’un des outils pédagogiques essentiels dans les études de santé. La simulation avec patient simulé (PS) permet d’aborder des compétences différentes de la simulation procédurale ou de haute technicité, aussi bien en formation qu’en évaluation. Objectif : Présenter les modalités ayant conduit à la création d’un groupe de patients simulés bénévoles. Méthodes : Le recrutement des candidats est fait par des voies diverses. Une étape de sélection est réalisée pour tous les candidats par un binôme médecin-psychologue. La formation des futurs PS dure une journée et comprend une information sur les principes de la simulation, les mécanismes de défenses psychologiques et une formation aux jeux des émotions et de la douleur. Résultats : Cent-treize personnes ont répondu aux annonces de recrutement, 104 ont été retenues après sélection, 99 ont eu la formation de PS et, finalement, 87 ont participé aux sessions de formation ou d’évaluation des apprenants, dont 67 étudiants en médecine et neuf retraités. Conclusion : Pour le centre de simulation, le recrutement de PS bénévoles permet d’envisager le développement d’un nouveau champ d’activités de formation et d’évaluation. Pour les étudiants en médecine, la participation à ces activités constitue une initiation à la relation médecin-patient et une forme de préparation aux modalités des examens cliniques objectifs et structurés (ECOS).
Assessment of NLRP3 Gene Polymorphisms with Periodontitis as Compared with Healthy Periodontium in Iraqi Arabs Patients
Authors: Mahmood Athraa A. , Abbas Raghad Fadhil 
Published: February 2023

Abstract
Objectives The nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome regulates the maturation and release of the cytokines as well as the activation of caspase in response to danger signals derived from pathogenic infection, tissue damage, andmetabolic changes that have a role in the pathogenesis of different diseases as periodontitis. Yet, the susceptibility to this illness could be determined by population-based genetic differences. The aim of this study was to determine whether periodontitis in Arab populations from Iraq is correlated with NLRP3 gene polymorphisms and measure clinical periodontal parameters and investigate their association with genetic polymorphisms of the NLRP3.
Materials and Methods The study sample consisted of 94 participants ranging from 30 to 55 years old, both males and females who fulfilled the study's criteria. The selected participants were divided into two groups: the periodontitis group (62 subjects) and the healthy control group (32 subjects). The examination of clinical periodontal parameters of all participants was carried out, followed by a collection of venous blood for NLRP3 genetic analysis using the polymerase chain reaction–sequencing technique.
Results The genetic analysis of NLRP3 genotypes at four single nucleotide polymorphisms (SNPs) (rs10925024, rs4612666, rs34777555, and rs10754557), by Hardy–Weinberg equilibrium, identified nonsignificant differences in studied groups. The C-T genotype among periodontitis was significantly different from controls, while the C-C genotype among control was significantly different from periodontitis at NLRP3 rs10925024. Overall, there were 35 SNPs in the periodontitis group and 10 SNPs in the control group for rs10925024 with significant differences versus nonsignificant differences of the other SNPs between the studied groups. Clinical attachment loss and NLRP3 rs10925024 additionally demonstrated a significant positive correlation in the periodontitis subjects.
Conclusion The findings suggested that polymorphisms of the NLRP3 gene may have a role and increasing the genetic susceptibility to periodontal disease in Arabs Iraqi patients.
Management of Surgically Accessible Lymph Nodes Beyond Normal Resection Planes
Authors: deLahunta Daniel , Nalamati Surya 
Published: February 2023

AbstractThis article discusses the management of isolated metastatic lymph nodes for colon and rectal cancer. There are traditionally significant differences in how certain regions of lymph nodes for colon and rectal cancer are managed in the East and West. This has led to the development of the lateral lymph node dissection for rectal cancer and extended lymphadenectomy techniques for colon cancer. This article will evaluate the literature on these techniques and what the surgical and oncological outcomes are at this time. In addition, colon and rectal cancers can occasionally have isolated distant lymph node metastases. These would traditionally be treated as systemic disease with chemotherapy. There is consideration though that these could be treated as similar to isolated liver or lung metastases which have been shown to be able to be treated surgically with good oncological results. The literature for these isolated distant lymph node metastases will be reviewed and treatment options available will be discussed.
Bioengineering an Osteoinductive Treatment for Bone Healing Disorders: A Small Animal Case Series
Authors: Marshall William G. , Gonzalez-Garcia Cristina , Trujillo Sara , Alba-Perez Andres , Childs Peter , Shields David W. , Tomlinson Andrew , Pettitt Rob , Filliquist Barbro , Chou Po-Yen , Dalby Matthew J. , Corr Sandra A. , Salmeron-Sanchez Manuel 
Published: February 2023

AbstractThe aim of this article was to study clinical and radiographic outcomes following treatment of bone healing disorders with a novel osteoinductive system that utilizes poly (ethyl acrylate), fibronectin and an ultra-low concentration of recombinant human bone morphogenetic protein-2. A case series of nine dogs and two cats were treated, and clinical records and radiographs were reviewed. Radiographs were scored by two blinded observers using the modified Radiographic Union Score for Tibial Fractures. Long-term follow-up was obtained using the Canine Orthopaedic Index and Feline Musculoskeletal Pain Index. Follow-up data were available for 11 treatments (10 cases). Complications: three minor, three major, one catastrophic (non-union requiring amputation). Lameness median 320 (range: 42–1,082) days postoperatively: ‘sound’ (three cases), ‘subtle’ (two), ‘mild’ (three), ‘moderate’ (one), and ‘non-weightbearing’ (one). The attending clinician judged 9 of 11 treatments achieved radiographic union; modified Radiographic Union Score for Tibial Fractures observers 1 and 2 agreed with the clinician in 8/9 and 5/9 treatments respectively. Long-term Canine Orthopaedic Index scores for five dogs median 650 (range: 544–1,724) days postoperatively: 15/64 (median) for four dogs with acceptable outcomes, 30/64 in one dog with a poor outcome. Feline Musculoskeletal Pain Index scores for two cats 433 and 751 days postoperatively: 48/60 and 60/60. Eight of 10 cases were sound or showed subtle or mild lameness in the short- or long-term, and radiographic union occurred in the majority of treatments.
The evolutionary mechanism of haze collaborative governance: novel evidence from a tripartite evolutionary game model and a case study in China
Authors: Zhang Zhenhua , Zhang Guoxing , Hu Yi , Jiang Yating , Zhou Cheng , Ma Jiahui 
Published: February 2023

AbstractThe topic of haze collaborative governance has become a hot policy issue attracting worldwide attention. However, existing studies do not pay enough attention to haze collaborative governance in the process of central environmental protection inspection (CEPI). This paper employs a tripartite evolutionary game model to explore the evolutionary mechanism of haze collaborative governance among China’s central and local governments and verifies its findings further through a case study of CEPI for air pollution in Beijing-Tianjin-Hebei and surrounding regions. The results show that haze collaborative governance is mainly affected by the performance evaluation system, policy implementation cost, clean government construction, industrial transfer trend, fiscal subsidy, environmental inspection cost, environmental accountability, and public participation. The implementation of CEPI is conducive to haze collaborative governance among central government and local governments. To promote the full implementation of air pollution control policies, the local governments need to optimize the performance evaluation system by considering economic development and environmental protection, reduce policy implementation costs by cost-sharing, and strengthen clean government construction by preventing rent-seeking corruption. In addition, the local governments need to strengthen the coordination of cross-regional industrial development and optimize fiscal subsidies to promote ecological compensation and transfer payments. For supervising the policy implementation of local governments thoroughly, the central government needs to reduce the environmental inspection cost using the evaluation framework of cost-benefit analysis, strengthen the haze governance accountability through normalizing supervision, and broaden the public’s external supervision channels. It is vital to take effective measures to carry out haze collaborative governance, providing a useful experience for developing countries.
Transcriptome age of individual cell types in
Caenorhabditis elegans
Authors: Ma Fuqiang , Zheng Chaogu 
Published: February 2023

The phylotranscriptomic analysis of development in several species revealed the expression of older and more conserved genes in midembryonic stages and younger and more divergent genes in early and late embryonic stages, which supported the hourglass mode of development. However, previous work only studied the transcriptome age of whole embryos or embryonic sublineages, leaving the cellular basis of the hourglass pattern and the variation of transcriptome ages among cell types unexplored. By analyzing both bulk and single-cell transcriptomic data, we studied the transcriptome age of the nematode
Caenorhabditis elegans
throughout development. Using the bulk RNA-seq data, we identified the morphogenesis phase in midembryonic development as the phylotypic stage with the oldest transcriptome and confirmed the results using whole-embryo transcriptome assembled from single-cell RNA-seq data. The variation in transcriptome ages among individual cell types remained small in early and midembryonic development and grew bigger in late embryonic and larval stages as cells and tissues differentiate. Lineages that give rise to certain tissues (e.g., hypodermis and some neurons) but not all recapitulated the hourglass pattern across development at the single-cell transcriptome level. Further analysis of the variation in transcriptome ages among the 128 neuron types in
C. elegans
nervous system found that a group of chemosensory neurons and their downstream interneurons expressed very young transcriptomes and may contribute to adaptation in recent evolution. Finally, the variation in transcriptome age among the neuron types, as well as the age of their cell fate regulators, led us to hypothesize the evolutionary history of some neuron types.
Highly sensitive salinity and temperature measurement based on tapered-SHF MZI fiber laser structure
Authors: Zhao Fang , Lin Weihao , Hu Jie , Liu Shuaiqi , Yu Feihong , Chen Xingwei , Wang Guoqing , Shum Perry Ping , Shao Liyang 
Published: February 2023

Abstract
A novel Mach–Zehnder interferometer (MZI) based on tapered-side-hole-fiber (SHF) fiber laser structure, which has obvious advantages in salinity and temperature measurement sensitivity, is analyzed both theoretically and experimentally. The tapered-SHF structure is used as a sensing element and an optical filter, which is connected to the erbium-doped fiber to form a fiber ring laser (FRL). Based on the linear correspondence between the output spectra of the FRL and the salinities, the salinity around the sensing area is measured by the MZI. The FRL has the unique advantages of high resolution, narrow line width, high optical signal-to-noise ratio, and high stability. Compared with the transmission spectrum of conical SHF in the broadband light source, these advantages are more suitable for sensing applications. The experimental results show that the finer the taper diameter, the higher the sensitivity of salinity and temperature. When the taper diameter is 8.23 μm, the salinity sensitivity of the sensor can reach 0.3347 nm/‰, and the temperature sensitivity can reach −0.4270 nm °C−1.