bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large amoutnts of mercury residue found in a child: a case report
Authors: Du Xifeng , Xia Anning , Sun Junying , Ye Yinting 
Published: June 2023

Abstract
Background: This case report describes a rare and unfortunate incident involving a 14-month-old child who was exposed to mercury. The purpose of this case report is to share the unique and typical image findings of residual mercury in a foreign body, which can aid clinicians in identifying similar cases and providing effective treatment.
Case presentation: A 14-month-old child presented with mercury residue in their body, following its discovery in the child's bed. Urine tests showed elevated levels of mercury, and X-rays revealed a large amount of mercury in the child's upper arms and lungs. The patient underwent timely surgical treatment, and while they are currently recovering, they still require ongoing medication and additional treatments.
Conclusions: Pediatric exposure to toxic substances such as mercury can have significant consequences for young patients. Early recognition and prompt intervention can prevent significant morbidity and mortality associated with toxicity. Clinicians should be aware of the risks and potential complications associated with heavy metal exposure and take appropriate measures to protect susceptible populations. In addition, sharing image data of unique and typical cases can aid clinicians in identifying similar cases and providing effective treatment.
Clinical reliability and validity of a video-based markerless gait evaluation method
Authors: Lin Jincong , Wang Yongtao , Sha Jia , Li Yi , Fan Zongzhi , Yan Yabo , Lei Wei 
Published: June 2023

Abstract
This study explored the reliability and validity of gait parameters obtained from gait assessment system software employing a human posture estimation algorithm based on markerless videos of children walking in clinical practice. Eighteen healthy children were recruited to walk along a designated sidewalk at a comfortable walking speed. A 3-dimensional gait analysis (3D GA) and a 2-dimensional markerless (2D ML) gait evaluation system were used to extract the gait kinematics parameters twice at an interval of 2 h. The two measurements of the children’s kinematic gait parameters revealed no significant differences (P > 0.05). Intra-class correlation coefficients(ICCs) were generally high(ICC>0.7), showing moderate to good relative reliability. The standard error of measurement (SEM) values of all gait parameters measured by the two walks were 1.26°– 2.91°. The system software had good to excellent validity compared to the 3D GA, with ICC values between 0.835 and 0.957 and SEM values of 0.87° to 1.71° for the gait parameters measured by both methods. The Bland-Altman plot analysis indicated no significant systematic errors. The results suggest that the markerless gait assessment method using the human posture estimation-based algorithm may provide reliable and valid gait analysis results for practical clinical applications.
Study on the influence law of spray layer cavity on the main reinforcement of grid steel frame
Authors: Qi Chuande , Liu Junfeng , Zong Chao , Jiang Weiliang , Li Weiteng , Li Yang , Yan Jianquan 
Published: June 2023

Abstract
The field monitoring data showed that a small amount of main reinforcement of lattice girder at the arch of a tunnel was under tension, and the calculation showed that the initial support structure should be under circumferential compression. In order to find out the reason for the tension of the steel frame main reinforcement, the geological radar was used and detected the cavity in the spray layer at the tension position. In order to further clarify the tension mechanism of the main reinforcement and the influence of factors such as the position and size of the cavity on the main reinforcement, numerical simulations were carried out, the results show that the cavity causes the eccentric compression of the shotcrete layer, resulting in the local bending moment of the lattice girder and the change of the stress distribution of the main reinforcement, when the size of the cavity exceeds 3m × 0.2m will cause local tension of nearby main reinforcement; The position of the cavity has a significant impact on the stress condition of the main reinforcement. Compared with the arch crown and arch waist, the cavity at the arch foot is more likely to produce large tensile stress on the main reinforcement, the size of the cavity is 6m × 0.2m causes 81MPa tensile stress in the main reinforcement. The research results provide a theoretical basis for the interpretation and analysis of tunnel lattice girder monitoring data.
Splitter of topological photonic waveguide in semiconductor platform
Authors: Amemiya Tomohiro , Okada Sho , Kagami Hibiki , Nishiyama Nobuhiko , Wang Xing-Xiang , Hu Xiao 
Published: June 2023

Abstract
We propose a splitter that can separate a topological photonic waveguide into two branches with the desired relative wave intensity while keeping the waveguide mode intact. The device consists of semiconductor photonic crystals, topological insulators, and trivial insulators surrounding a rhombic patch X, with X varying from trivial to topological via a graphene-like semimetal, all formed by arranging nano airholes in patterns of C6v symmetry. Patch X establishes an effective potential for the input topological wave function, guiding it to the two output ports in a tunnelling-like manner with the desired relative intensity. Our Si-photonics fabricated splitter achieves continuous power ratios between output ports from 10.22 dB to -9.17 dB. With a miniaturised size of ~ 10 µm, it surpasses conventional silicon-based Y-splitters. This breakthrough in controlling topological photonic waveguide splitting is vital for high-performance topological photonic integrated circuits (TPICs), opening up new possibilities for innovative functionality across diverse platforms.
The Influence of a Previous Implant-Based Breast Reconstruction on Postoperative Sensation of the Deep Inferior Epigastric Artery Perforator Flap
Authors: Rooij Joep A.F. van , Bijkerk Ennie , Hulst René R.W.J. van der , Tuinder Stefania M.H. 
Published: June 2023

Abstract
Background
Implants and DIEP flaps have different outcomes regarding postoperative breast sensation. When compared to the preoperative healthy breast, implant-based breast reconstruction (IBBR) negatively influences postoperative breast sensation. However, it is currently unknown whether a prior IBBR also influences postoperative sensation of a replacing DIEP flap. The goal of this cohort study is to evaluate the influence of an IBBR on the postoperative sensation of a replacing DIEP flap.
Methods
Women were included if they received a DIEP flap reconstruction after mastectomy, with or without prior tissue expander (TE) and/or definitive breast implant. Sensation was measured at four intervals in 9 areas of the breast with Semmes-Weinstein monofilaments: T0 (preoperative, implant/no reconstruction), T1 (2–7 months postoperative, DIEP), T2 (± 12 months postoperative, DIEP), Tmax (maximum follow-up, DIEP). Linear mixed models were used to investigate the relationship between an implant/TE prior to the DIEP flap and recovery of breast sensation.
Results
142 women comprising 206 breasts were included. 48 (23.3%) breasts did, and 158 (76.7%) breasts did not have a TE/IBBR prior to their DIEP. No statistically significant or clinically relevant relationships were found between a prior implant/TE and recovery of DIEP flap breast sensation for the flap skin, native skin, or total breast skin at T1, T2, or Tmax. There were also no relationships found after adjustment for the confounders radiation therapy, BMI, diabetes, age, flap weight, follow-up, and nerve coaptation.
Conclusions
An implant/TE prior to a DIEP flap does not influence the recovery of postoperative breast sensation of the DIEP flap.
Identification of non-native population and reconstruction of invasion routes in the Redbreast Sunfish Lepomis auritus
Authors: Kim Daemin , Simmons Jeffrey W. , Near Thomas J. 
Published: June 2023

Abstract
Non-native species pose major threats to native biodiversity and human-mediated introduction of species is expected to increase globally. Lepomis auritus (Redbreast Sunfish), a carnivorous freshwater fish native to rivers in eastern North America, has been introduced far outside of its native range due to its popularity in recreational fisheries. However, poor documentation of introductions and lack of thorough ichthyofaunal surveys before the mid-20th century prevent a confident reconstruction of non-native populations of L. auritus over the past 90 years, resulting in a failure to develop proper invasive species management. Phylogenomic analyses of ddRAD data identify non-native populations of L. auritus that are now abundant in rivers of high conservation priority, which highlights the need for invasive species management for these populations. Our protocols allow for the reconstruction of complicated introduction routes and reveal that L. auritus in Texas is the result of a single-source introduction from the Suwannee River, the population in the upper Tennessee River has two sources of introduction from the Savannah River and the northeastern rivers that drain into the Atlantic Ocean, and the upper Tennessee River and Apalachicola River were the introduction sources for the populations in the middle Tennessee River and the Mobile River Basin. Ecological and evolutionary investigations of the non-native populations of L. auritus will broaden the understanding of biological invasions.
Effect of Hydrochloric Acid Hydrolysis under Sonication-Hydrothermal Process to Produce Cellulose Nanocrystal from OPEFB
Authors: Zulnazri Zulnazri , Muarif Agam , Roesyadi Acmad , Dewi Rozanna , Sangian Hanny F. 
Published: June 2023

Abstract
An approach for hydrolyzing cellulose nanocrystals from oil palm empty fruit bunch (OPEFB) presented through hydrochloric acid hydrolysis under sonication-hydrothermal conditions. The influence of concentration, reaction time and acid to cellulose ratio will be studies toward the yield, crystallinity, microstructure and thermal stability. The highest yield of cellulose nanocrystals up to 74.82%, crystallinity until 78.59%, and a maximum degradation temperature (Tmax) of 339.82°C can be achieved through hydrolysis using 3M HCl at 110°C during 1 hours. X-ray diffraction analysis indicated higher diffraction peak pattern at 2θ = 22,6ᴼ and low diffraction peak pattern at 2θ = 18ᴼ. All of cellulose nanocrystals showed crystalline size under 1 nm, it is indicated that sonication-hydrothermal process can reduce crystalline size of cellulose. Infrared spectroscopy analysis showed there has been deletion of lignin and hemicellulose that are shown at spectrum. Cellulose nanocrystals morphology showed more compact structure and well-ordered surface arrangement than cellulose morphology. Cellulose nanocrystals also have good thermal stability as indicated by high maximum degradation temperature.
Exploring the relation between NPP-VIIRS Nighttime Lights and Carbon Footprint, Population Growth, and Energy Consumption in the UAE
Authors: Gafoor Fahim Abdul , Cho Chung Suk , Shehhi Maryam R. Al 
Published: June 2023

Abstract
Due to global warming and its detrimental effect, every country is responsible to join the global effort to reduce carbon emissions. In order to improve the mitigation plan of climate change, accurate estimates of carbon emissions, population, and electricity consumption are critical. Carbon footprint is significantly linked to the socioeconomic development of the country which can be reflected in the city's infrastructure and urbanization. We may be able to estimate the carbon footprint, population growth, and electricity consumption of a city by observing the nighttime light reflecting its urbanization. This is more challenging in oil-producing countries where urbanization can be more complicated. In this study, we are therefore investigating the possibility of correlating the remotely sensed NPP-VIIRS Nighttime light (NTL) estimation with the aforementioned socioeconomic indicators. Daily NPP-VIIRS NTL were obtained for the period between 2012 to 2021 for the United Arab Emirates (UAE) which is one of the top oil producing countries. The socioeconomic indicators of the UAE, including the population, electricity consumption, and carbon dioxide emissions, have been obtained for the same period. The analysis of the correlation between the NTLs and the population indicates that there is a high correlation of more than 0.9. There is also a very good correlation of 0.7 between NTLs and carbon emissions and electricity consumption. However, these correlations differ from one city to another. For example, Dubai has shown the highest correlation between population and NTLs (R2 > 0.8). However, the correlation was the lowest in Al-Ain, a rural city (R2 < 0.4) with maximum electricity consumption of 1.1 ×104 GWh. These results demonstrate that NTLs can be considered as a promising proxy for carbon footprint and urbanization in oil-producing regions.
Predictors of Menstrual Hygiene Management Among Adolescent Girls (aged 10-19) in a resource-deprived setting in Bukedea District, Uganda
Authors: Bagenda Dominic K. , Komuhangi Alimah , Galukande Moses 
Published: June 2023

Abstract
Background: Menstrual hygiene management (MHM) is a public health challenge in resource-deprived settings and if not properly managed, menstruation can interrupt daily life. We collected data on MHM and factors predicting its adequacy among adolescent girls (10-19 years) in a rural setting of Bukedea District, Uganda.
Methods: We conducted a cross-sectional study between December 2021 and March 2022 in 13 resource-deprived villages in Kangole and Kabarwa sub-counties of Bukedea district and randomly sampled 168 adolescent girls using an interviewer administered questionnaire and a checklist. MHM was deemed adequate if respondents reported that they had clean menstrual management material to absorb or collect blood, sufficient quantities of water and soap, were able to change menstrual materials at least thrice a day, in privacy, and dispose of used menstrual material at designated facilities. Fisher’s Exact Test was used to determine significant associations while the factors independently associated with adequacy of MHM were determined using modified Poisson regression analysis and reported as adjusted prevalence rate ratios (aPRR) with corresponding 95% confidence intervals (CI).
Results: Of 168 participants enrolled, MHM was adequate for 21 (12.5%) and the likelihood of adequacy was higher among girls who had menarche before 11 years of age (aPRR 4.02; 95% CI 1.45 – 11.12), were aged 19 (aPRR 3.31; 95% CI 1.58 – 6.93), or were attending the local high school (aPRR 2.99; 95% CI 1.34 – 6.68).
Conclusions: The adequacy of MHM among adolescent girls in Bukedea District is considerably lower than the national average. Increasing access to secondary education could promote adequate MHM.
Incidence, prognostic factors, and a nomogram of lung metastases at diagnosis: a pan-cancer population-based study
Authors: Xu Zihan , Wang Li , Zhao Yuxin , Liu Tao , Tu Li , He Yingying , Luo Feng 
Published: June 2023

Abstract
Lung metastasis is common and usually associated with poor outcomes in cancer patients. Currently, the epidemiologic and survival data of synchronous lung metastases (SLM) are lacking. We collected 61,493 patients who were diagnosed with lung metastases at the time of primary cancer diagnosis between 2010 and 2017. The age-adjusted incidence of SLM increased from 9.86/100,000 in 2010 to 12.03/100,000 by 2017 [APC: 3.08; 95% CI: 2.30–3.86]. For adults > 35, digestive system cancer is the most common primary site. For younger patients, the top cancers with SLM were more heterogenous. Survival analysis of SLM patients with different primary tumor types suggested that the median OS was the best for the male genital system malignances and the worst for the digestive system malignances. Furthermore, a nomogram comprising age, race, gender, grade, tumor size, N stage and sites was established to predict the 1-/3-/5-year survival probability of patients with SLM, with the C-indexes of 0.628 (95% CI: 0.622–0.634) for the internal validations and 0.620 (95% CI: 0.610–0.630) for the external validations. In conclusion, the incidence of SLM has continued to increase recent years, and a nomogram based on prognostic analysis could accurately quantify the survival rates of patients with SLM.
Comparison of birth outcomes of mothers covered by Medicaid versus those privately insured when accounting for social determinants of health
Authors: Damodaran Kriti , Brumberg Heather , Jawale Nilima , Giblin Clare , Shah Shetal 
Published: June 2023

Abstract
Objectives: To determine the association between maternal health insurance type & birth outcomes [prematurity, small for gestational age (SGA), Term/Appropriate for gestational age NICU admission (Term/AGA-NICU) & composite birth outcomes (CBO)] accounting for social determinants of health.
Design/Methods: Cross-sectional study of maternal surveys and birth certificate data of singleton live births in NY born to mothers with Medicaid (M) or Private Insurance (PI).
Results: 1015 mothers [M= 631, PI= 384) included. Individual birth outcomes did not differ between groups. Adjusting for social, demographic and clinical covariates, M mothers had similar odds of preterm birth, SGA, Term/AGA-NICU admission and CBO compared to PI.
Conclusions: M mothers were as likely as PI mothers to deliver a preterm, SGA or a Term/AGA-NICU infant after controlling for social determinants of health. Despite more social adversity among enrollees, our study suggests NY Medicaid recipients have similar birth outcomes to privately insured, socially advantaged women.
Rev1-Rev7 Complex Inhibitor JH-RE-06 Enhances Mitomycin C Chemosensitivity in HCT116 Colorectal Cancer Cells
Authors: Cheng Jianhua , Sun Haotong , Ma Wenye , Xu Jie , Hao Yanjie , Wang Feimiao , Li Xin , Wang Huan , Ling Jun , Xu Fang 
Published: June 2023

Abstract

Background: Cancer cells can develop resistance to DNA interstrand crosslinker agents through a DNA repair bypass pathway called TLS. JH-RE-06, a TLS-targeting inhibitor, has been shown to increase melanoma cell susceptibility to cisplatin. Nevertheless, whether JH-RE-06 can be used in combination with Mitomycin C (MMC) to benefit Colorectal Cancer (CRC) patients receiving hyperthermic intraperitoneal chemotherapy (HIPEC) treatment remains unknown.
Methods: Colon adenocarcinoma (COAD) and Rectum adenocarcinoma (READ) data were obtained from The Cancer Genome Atlas (TCGA) database, and the expression of Rev1-associated proteins in normal and malignant tissues were compared to generate receiver operating characteristic curves (ROC) . The association between Rev1 and Rev7 expression and the prognosis of CRC patients was derived from the PrognoScan database. Expression at the protein level was verified with a tissue microarray. Western blot was performed to identify alterations in the protein levels of Rev1 and Rev7 following MMC treatment of HCT116 cells, whereas CCK8 revealed alterations in the IC50 value of MMC following the knockdown of Rev7 and Rev1. Co-Immunoprecipitation for the targeting of JH-RE-06. EdU demonstrated the inhibitory effect of JH-RE-06 and MMC on cancer cell growth; Wound healing, and clone formation assays were carried out to evaluate the cell migration and clone formation abilities, respectively. Flow cytometry analysis was performed to detect cell apoptosis, and a commercial reagent kit was used to detect ROS and NAD+/NADH changes. Immunofluorescence was used to analyze cellular DNA damage. Finally, the potential mechanism of action and targets of JH-RE-06 in the treatment of CRC were investigated by network pharmacology.
Results: Analysis of bioinformatics data revealed high expression of Rev1 and Rev1-associated proteins Rad18, Rev3, and Rev7 in CRC tumor tissues compared to normal tissues, with Rad18 and Rev7 showing high diagnostic values for CRC. High Rev1 expression was associated with a poor prognosis, whereas high Rev7 expression was associated with a favorable prognosis. The protein-level expression of Rev1 and Rev7 was verified by immunohistochemistry, indicating that the downregulation of Rev1 and Rev7 may increase HCT116 susceptibility to MMC treatment. Co-treatment with JH-RE-06 may augment the therapeutic efficacy of MMC in CRC cells, increase cell apoptosis, mitochondrial and DNA damage, and limit cancer cell migration and clone formation. Results from network pharmacology revealed that JH-RE-06 treatment may also involve the MAPK, PI3K, and Akt signaling pathways.
Conclusions: Rad18 and Rev7 can be employed as predictive biomarkers for CRC. Targeting TLS renders HCT116 sensitive to MMC treatment, and JH-RE-06 has the potential to serve as a combination therapy medication for the MMC treatment of peritoneal metastatic CRC in HIPEC.
Validation of phytochemicals from Houttuynia cordata for their effect on dipeptidyl peptidase IV and sodium/glucose cotransporter 2: an in silico study
Authors: Pakyntein Careen Liza , Thabah Daiahun , Syiem Donkupar , Rai Anita Kumari 
Published: June 2023

Abstract

The study identified and screened phytochemicals present in Houttuynia cordata and characterized their ADME/Tox properties. The powdered plant extracted using water and methanol for about 24h was refluxed, filtered, and evaporated to dryness under reduced pressure and subjected to High-Performance Thin Layer Chromatography, and Gas Chromatography tandem mass spectrometry analysis using a standard protocol. The compounds identified from Houttuynia cordata were docked with antidiabetic targets- dipeptidyl peptidase-IV and sodium/glucose cotransporter 2. High-Performance Thin Layer Chromatography and Gas Chromatography tandem mass spectrometry analysis showed the presence of several compounds by matching their recorded spectra with the data bank mass spectra from the NIST library. ADME/Tox properties and docking of the identified compounds indicate the potentiality of the compounds as drug candidates. Selected compounds from Houttuynia cordata have good pharmacokinetic properties and binding affinity for DPP-IV and SGLT2. However, the isolation of these phytoconstituents and their in vivo activity will help give a better insight and will open a new area of investigation of individual components and their pharmacological potency.