bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the current state of rangelands in Karakalpak Ustyurt, Uzbekistan
Authors: RAKHIMOVA NODIRA K. , RAKHIMOVA TASHKHANIM , SHOMURODOV KHABIBULLO F. , ADILOV BEKHZOD А. , SHARIPOVA VASILA K. , SAITJANOVA UMIDA SH. , KHABIBULLAEV BEKHRUZ SH. , SADINOV JASUR S. , POLVONOV FARRUKH I. , SULTAMURATOV AZAMAT T. 
Published: September 2023

Abstract. Rakhimova NK, Rakhimova T, Shomurodov KhF, Adilov BA, Sharipova VK, Saitjanova USh, Khabibullaev BSh, Sadinov JS, Polvonov FI, Sultamuratov AT. 2023. Assessment of the current state of rangelands in Karakalpak Ustyurt, Uzbekistan. Biodiversitas 24: 3835-3843. Assessing the current state of rangelands common in the territory of Karakalpak Ustyurt, Uzbekistan is of great importance in connection with intense land degradation and climate change. The article is devoted to study the main attributes and indicators for qualitative and quantitative assessment of rangelands including the current state of vegetation, soil cover and use of fodder resources. The studied types of rangelands are common on gray-brown desert soils, takyrs, and salt marshes, characterized by high gypsum content. Rangeland vegetation of Ustyurt, composed mainly of Artemisia terrae-albae Krasch., Anabasis salsa (Ledeb.) Benth. ex Volkens, Xylosalsola arbuscula (Pall.) Tzvelev, Salsola arbusculiformis Drobow, Caroxylon orientale (S.G. Gmel.) Tzvelev, ephemera, and other plant species, is the main fodder source for Karakul sheep and camels. The nutritional value of rangeland varieties is quite high in spring, it is characterized by an increased content of digestible protein in this period and decreases towards autumn, while the above-ground yield of species reaches its maximum growth. Autumn and winter-spring precipitation play the main role in the fodder productivity of rangelands. The productivity of rangelands depends on the favorable climatic conditions of the year, if more precipitation falls, the year will be more favorable for the growth and development of plants.
Molecular characterization of a novel serine proteinase from Trichinella spiralis and its participation in larval invasion of gut epithelium
Authors: Song Yan Yan , Zhang Xin Zhuo , Wang Bo Ning , Weng Min Min , Zhang Zhao Yu , Guo Xin , Zhang Xi , Wang Zhong Quan , Cui Jing 
Published: September 2023

Background
A novel serine proteinase of Trichinells spiralis (TsSPc) has been identified in the excretion/secretion (ES) antigens, but its role in larval invasion is unclear. The aim of this study was to clone and express TsSPc, identify its biological and biochemical characteristics, and investigate its role on larval invasion of gut epithelium during T. spiralis infection.

Methodology/Principal findings
TsSPc has a functional domain of serine proteinase, and its tertiary structure consists of three amino acid residues (His88, Asp139 and Ser229) forming a pocket like functional domain. Recombinant TsSPc (rTsSPc) was expressed and purified. The rTsSPc has good immunogenicity. On Western blot analysis, rTsSPc was recognized by infection serum and anti-rTsSPc serum, natural TsSPc in crude and ES antigens was identified by anti-rTsSPc serum. The results of qPCR, Western blot and indirect immunofluorescence test (IIFT) showed that TsSPc was expressed at diverse stage worms, and mainly localized at cuticle, stichosome and intrauterine embryos of this nematode. The rTsSPc had enzymatic activity of native serine protease, which hydrolyzed the substrate BAEE, casein and collagen I. After site directed mutation of enzymatic active sites of TsSPc, its antigenicity did not change but the enzyme activity was fully lost. rTsSPc specifically bound to intestinal epithelium cells (IECs) and the binding sites were mainly localized in cell membrane and cytoplasm. rTsSPc accelerated larval invasion of IECs, whereas anti-rTsSPc antibodies and TsSPc-specific dsRNA obviously hindered larval invasion.

Conclusions
TsSPc was a surface and secretory proteinase of the parasite, participated in larval invasion of gut epithelium, and may be considered as a candidate vaccine target molecule against Trichinella intrusion and infection.
N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4
Authors: Zhang Chunyan , Cui Yuanbo 
Published: September 2023

Abstract
N6-methyladenosine (m6A) and N7-methylguanosine (m7G) modification of RNA represent two major intracellular post-transcriptional regulation modes of gene expression. However, the crosstalk of these two epigenetic modifications in tumorigenesis remain poorly understood. Here, we show that m6A methyltransferase METTL3-mediated METTL1 promotes cell proliferation of head and neck squamous cell carcinoma (HNSC) through m7G modification of the cell-cycle regulator CDK4. By mining the database GEPIA, METTL1 was shown to be up-regulated in a broad spectrum of human cancers and correlated with patient clinical outcomes, particularly in HNSC. Mechanistically, METTL3 methylates METTL1 mRNA and mediates its elevation in HNSC via m6A. Functionally, over-expression of METTL1 enhances HNSC cell growth and facilitates cell-cycle progress, while METTL1 knockdown represses these biological behaviors. Moreover, METTL1 physically binds to CDK4 transcript and regulates its m7G modification level to stabilize CDK4. Importantly, the inhibitory effects of METTL1 knockdown on the proliferation of HNSC, esophageal cancer (ESCA), stomach adenocarcinoma (STAD), and colon adenocarcinoma (COAD) were significantly mitigated by over-expression of CDK4. Taken together, this study expands the understanding of epigenetic mechanisms involved in tumorigenesis and identifies the METTL1/CDK4 axis as a potential therapeutic target for digestive system tumors.
Local parameter selection in the C0 interior penalty method for the biharmonic equation
Authors: Bringmann Philipp , Carstensen Carsten , Streitberger Julian 
Published: September 2023

Abstract
The symmetric C0 interior penalty method is one of the most popular discontinuous Galerkin methods for the biharmonic equation. This paper introduces an automatic local selection of the involved stability parameter in terms of the geometry of the underlying triangulation for arbitrary polynomial degrees. The proposed choice ensures a stable discretization with guaranteed discrete ellipticity constant. Numerical evidence for uniform and adaptive mesh refinement and various polynomial degrees supports the reliability and efficiency of the local parameter selection and recommends this in practice. The approach is documented in 2D for triangles, but the methodology behind can be generalized to higher dimensions, to non-uniform polynomial degrees, and to rectangular discretizations. An appendix presents the realization of our proposed parameter selection in various established finite element software packages.
Simulation of adsorption at rotating disk
Authors: Lovrić Milivoj 
Published: September 2023

Abstract
Diffusion-controlled adsorption at the rotating disk is calculated for Frumkin isotherm. The near equilibrium isotherms are simulated and their time components are analysed. The purpose of the work is to investigate the physical meanings of S-shaped isotherms that appear for strong attractions in the adsorbed layer. It is demonstrated that the surface coverage that is created gradually, by the diffusion process, consumes the concentration gradient of the dissolved surfactant in the diffusion layer. Once the equilibrium with the bulk of the solution is established, the driving force of diffusion-controlled adsorption vanishes and no additional adsorption is possible. The diffusion layer thickness on the rotating disk tends to the constant value and the flux depends only on the concentration of dissolved adsorbent at the disk surface. Hence, the equilibrium with the bulk of solution is established faster than at the stationary disk. This equilibrium takes an infinite amount of time to reach, but the system can approach close to the equilibrium within a definite period of time. The near equilibration time depends on the bulk concentration of surfactant. These relationships exhibit sharp maxima under the influence of attractions in the adsorbed layer.
A new layered potassium-based molybdenum–tungsten monophosphate: synthesis, crystal structure, XPS and magnetic studies
Authors: Goudjil Meriem , Lepore Giovanni Orazio , Bonazzi Paola , Mezaoui Djillali , Mezzi Alessio , Bolli Eleonora , Di Benedetto Francesco , Bindi Luca 
Published: September 2023

Abstract
A new compound, K5[(Mo3.2W1.8)O11](PO4)3[(P0.5Mo0.5)O4], was synthesized via solid-state reaction and its crystal structure was determined by single-crystal X-ray diffraction. This compound crystallizes in the space group Pnma, with a = 9.0360(4) Å, b = 10.1603(4) Å, c = 26.1538(12) Å and V = 2401.14(18) Å3. The structure consists of a corner-sharing MO6–TO4 (M = Mo, W; T = P, Mo) polyhedral connection arranged to form an ordered packing of ∼14.9 Å-thick layers parallel to (001). The stacking of the layers forms trigonal, tetragonal and hexagonal channels. XPS study reveals the presence of W at the hexavalent state only, whereas Mo appears as a mixed-valent species (Mo6+, Mo5+ and Mo4+). Magnetic susceptibility reveals the occurrence of a relevant antiferromagnetic coupling and is consistent with the presence of reduced metal species as indicated by the XPS results.
Gestión cultural en Guanacaste: Una travesía desde la danza
Authors: Alvarado Soto Rebeca 
Published: September 2023

This article presents the development of a work initiative with respect to two experiences in the specific area of teaching dance. The main purpose is to share and systematize experiences, from an interdisciplinary perspective, or more specifically: psychology, education and dance. This professional endeavor within the dance framework, was developed in the province of Guanacaste, in the city of Liberia in Costa Rica; where it was initiated in 2007 until the present. The methodology employed has, as its foundation, an integral perspective with an artistic and inclusive spirit. The latter conceived essentially as an expressive resource which consolidates an exploratory work based on the consciousness and daily experiences of the participants. The main result of such work being that of an increased closeness to different communities in diverse ways generating a greater demand from such populations to get to know the movement, and thus experiencing the physical sensations of the direct artistic creation. This search for artistic expression, recognizes the biopsychosocial benefits resulting from this daily practice. The above-mentioned program has sought to consolidate artistic spaces within particular social contexts in diverse communities in the country’s provinces. This in order to manage not only technical skills in ethe arts sphere, but as a way of promoting critical analysis with respect of the socio-cultural inequalities that take place between different geographical regions of Costa Rica.
Zooarchaeological Study of Quinta do Almaraz (Almada, Portugal)
Authors: Dias Íris , Olaio Ana , Rodrigues Miguel , Costa Pedro , Santos Ana Beatriz , Detry Cleia 
Published: September 2023

Archaeological excavations conducted in Quinta do Almaraz (Almada, Portugal) between 1986 and 2001 have allowed to identify a settlement with an important Iron Age occupation. These interventions provided a large assemblage of faunal remains and its study has enabled a detailed analysis of the diet, lifestyle, and habits of the people who lived in Almaraz during the 1st millennium B.C. The most abundant mammal species are sheep and goat, followed by pig. Cattle and wild species, such as red deer, are also present. We likewise highlight a great variety of bird species, including the first remains of domestic galliformes, up to then an exotic animal in Europe. Regarding malacofauna, we highlight the prevalence of clam, cockle, mussel, winkle, and limpet.
Desarrollo de Competencias Matemáticas en Secundaria Usando la Técnica de Aprendizaje Orientado en Proyectos
Authors: Arreguín Luz Elena , Alfaro Jorge A. , Ramírez Mª Soledad 
Published: September 2023

Este artículo presenta un estudio que tuvo por objetivo analizar el desarrollo de tres competencias matemáticas: planteamiento y resolución de problemas, comunicación y argumentación; con alumnos de segundo grado de secundaria, en una escuela pública mexicana, para identificar cómo impacta la técnica de aprendizaje orientada en proyectos (POL por sus siglas en inglés), como diseño instruccional innovador para mejorar los aprendizajes matemáticos de los estudiantes. La metodología utilizada fue el estudio de casos múltiples, aplicando instrumentos diversos tales como: el registro de bitácora, cuestionario, entrevista y análisis de proyectos aplicados a los estudiantes. Los hallazgos muestran el desarrollo de las tres competencias matemáticas al usar POL y resolver problemas de su interés y contexto, poniendo en juego un conjunto de capacidades como identificar, plantear y resolver problemas; explicando, justificando y demostrando.
Characteristics of Patients Associated With Restraint Use at a Midwest Children’s Hospital
Authors: DePorre Adrienne G. , Larson Ingrid , Staggs Vincent S. , Nadler Cy 
Published: September 2023

BACKGROUND AND OBJECTIVES
Restraint use is associated with negative mental health outcomes, injury risk, and known disparities in use. Improved understanding of restraint use among hospitalized children is critical given the increased frequency of hospitalized children with complex and/or acute mental health needs. Our objective is to describe the demographic and clinical features of children associated with mechanical restraint.

METHODS
In a single-center retrospective cohort study of patients hospitalized from 2017 to 2021, restraint encounters were identified from electronic health records. Odds of restraint was modeled as a function of patient demographic and clinical characteristics, as well as hospitalization characteristics using logistic regression modeling adjusted for clustering of hospitalizations within patients and for varying lengths of stay.

RESULTS
Among 29 808 children (46 302 encounters), 225 patients (275 encounters) had associated restraint use. In regression modeling, odds of restraint were higher with restraint at the preceding hospitalization (adjusted odds ratio [aOR] 8.6, 95% confidence interval [CI] 4.8–15.5), diagnosis of MH conditions such as psychotic disorders (aOR 5.4, 95% CI 2.7–10.4) and disruptive disorders (aOR 4.7, 95% CI 2.8–7.8), male sex (aOR 1.9, 95% CI 1.5–2.5), and Black race (aOR relative to White patients 1.9, 95% CI 1.4–2.6).

CONCLUSIONS
Our results suggest racial inequities in restraint use for hospitalized children. This finding mirrors inequities in restraint use in the emergency department and adult settings. Understanding the behavioral needs of such patients may help in reducing restraint use and improving health equity.
Factores que inciden en la productividad y competitividad de la Facultad de Ciencias Económicas, Administrativas y Contables de la UDES Cúcuta en el marco de la Economía del Conocimiento
Authors: González-Verjel May Stefanny , Bohórquez-Chacón Lesley Fabiola , Núñez-Rodriguez José de Jesús 
Published: September 2023

En el proceso enseñanza aprendizaje el currículo es un sistema regulador que orienta y regula el equilibrio teórico-práctico del proceso educativo, el cual es desarrollado por las instituciones de educación superior para generar conocimiento y ofrecer valor agregado al sector productivo; precisión que originó la idea del presente artículo cuyo objetivo es analizar los Factores que inciden en la productividad y competitividad de la [1]Facultad de Ciencias Económicas, Administrativas y Contables de la UDES Cúcuta en el marco de la Economía del Conocimiento; su elaboración está basada en una metodología de criterio cualitativo dentro de una investigación documental que analizó las consultorías sobre los temas objeto del conocimiento y de interés para el presente trabajo haciendo posible el análisis de los fundamentos conceptuales y el análisis de los resultados referentes a las brechas entre expectativas de empresarios y valor agregado de los egresados de los programas Administración Financiera, Contabilidad Pública, Mercadeo y Publicidad y Comercio Exterior, con base a los factores pertinentes que inciden en la productividad y competitividad de los programas, lo cual conllevó a la conclusión de que la UDES, Cúcuta debe reestructurar el currículo y el proyecto educativo institucional según áreas del conocimiento propuestas a través de un plan de acción
Workflow for Optimizing Horizontal Well Completions in Thinly Bedded Sandstone Reservoirs
Authors: Zhang Junjing , Zwarich Nola , Nozaki Manabu , Davis Eric , Metzgar Kyle 
Published: September 2023

Abstract
Recently appraised reservoirs in Alaska have hydrocarbons stored in highly laminated reservoirs with sandstone pays interbedded with tight mudstone and siltstone non-pays. Vertical flow barriers exist such that long horizontal wells with multi-stage longitudinal hydraulic fractures prove to be an effective way to connect the separated pay intervals and to increase the waterflooding sweep efficiency. This study presents a workflow to optimize the lower completion and hydraulic fracturing design for developing reservoirs with very limited vertical permeability.
Laboratory tests were performed to characterize the rock mechanical properties. The test results are used to predict formation failure and determine whether the lateral needs to be cemented to isolate weak rock. Fracture conductivity laboratory tests were also performed to determine the resultant conductivity for different proppant types and concentrations. A series of well inflow models were then constructed to investigate the completion design parameters such as the optimum frac sleeve spacing and required proppant concentration. Fracture models were built to determine the fracturing design that can deliver these parameters for the optimal reservoir development.
Laboratory geomechanics testing of thinly bedded laminated rock proved challenging and best practices to determine Poisson's ratio and UCS are presented. Formation failure modeling shows that a cemented completion is preferred when the wellbore is widely exposed to the weak, water-sensitive layers which are predicted to fail during early flowback period. In un-cemented liner completions, the weak intervals need to be mechanically isolated so that the failed rocks do not impede flow through the annulus between the openhole and production liner, sleeve ports or tubing. Fracture conductivity testing showed high proppant concentrations are required to achieve the conductivity targets due to a significant loss of fracture conductivity. Under idealistic conditions, un-cemented completions result in higher well productivity than cemented completions if the longitudinal fractures are fully aligned with the wellbore and the openhole annulus stays unplugged during the well life. However, well productivity for un-cemented liner completion decreases drastically when the wellbore misaligns with the fracture or formation failure occurs near the sleeve ports. Well productivity with cemented completions can be significantly improved by minimizing the near-field pressure drop through higher fracture conductivity and tighter frac sleeve spacing.
This study presents an integrated workflow to design effective completions for reservoirs with very limited vertical permeability. This couples the inflow performance model with the fracture model results for horizontal wells with multi-stage longitudinal fractures to optimize critical completion and fracture design parameters.
Case Study of Water Injection Frac Strategy at Bahja Rima Field at South Salt Oman Basin to Maximize Efficiency of Fields Recovery
Authors: Hadhrami Issa Al , Kalbani Mahmood Al , Musalami Sabriya Al , Saadi Faisal Al , Christiawan Arya , Yuyan Rioka 
Published: September 2023

Abstract
The Bahja Rima cluster consists of multiple fields which primarily target tight Cambro-Ordovician and Carboniforous-Permian oil sandstone reservoirs at the South Oman Salt basin petroleum system. The hydraulic propped fracturing has been the preferred practice of enhancing the well production performance at oil producers, with over 50 hydraulic fracturing works completed at this cluster in the last couple years from none. The well candidates are both from newly drilled wells and existing wells (NFA, No Further Activity) in which some of them are located within the perimeter of highly depleted pressure areas that need further strategy to maintain reservoir drive to flow the hydrocarbon.
At the reservoir scale study, it is determined to infill drilled numbers of water injector wells also some conversion injector wells. The same formation waters from the produced layer, presumably as the most compatible water source, were utilized as injection water. Throughout time however, the injectivity index was substantially dropped along with incremental injection pressure due to various issues including self-scaling from single source water at different pressure and temperature exposure. Throughout collaboration of multi-companies and multi-disciplines function, from Reservoir Engineering, Geologist, Petrophysicist, Production Technology and Frac Completion Specialist, it is determined hydraulic propped fracturing as the most economic method of improving the injectivity index hence impacting nearby producer wells production. Several specific boundary and criteria need to be investigated however, in order to properly deploy hydraulic fracturing on injector well candidate, this to include well integrity aspect, frac fluids and source water compatibility, optimum frac penetration, understanding of frac orientation towards water flood aerial sweeping, understanding of frac height towards water injection vertical sweeping effectiveness.
This paper describes the lesson learnt from fracturing design execution perspective and review of post fracture well injectivity performance in this cluster from 5 injector wells fracturing works performed in 2022 & 2023, and other offset producers well fracturing. The study results were summarized as best practice and recommendation moving forward for future injector wells fracturing on existing wells and also as drilling and completion strategy for new wells
Project Value Continuous Improvement: Invested Dollar with High Return in Oman
Authors: Al Shueili A. , Al Salmi H. , Jaboob M. , Al Qassabi M. , Kayumov R. 
Published: September 2023

Abstract
A holistic vision of potential stimulation-related continuous improvement projects in the early stages of the Khazzan project has led to massive cost reductions and high project value. bp took over operatorship of a tight gas block (Block 61) in the Sultanate of Oman in 2007, recognizing the huge potential upside in value through the placement of massive hydraulic fractures and associated cost and efficiency improvements by implementing a stimulation-related continuous improvement plan.
From the previous experiences across the globe, bp placed extensive focus on ways to continuously improve multiple components of fracture stimulations such as fracture design, fracturing fluids, proppants, flowback, fracturing equipment, fracturing logistics and many others. Since the first well was stimulated with hydraulic fracturing 13 years ago, cost savings and production enhancements have been realized through an aggressive approach to continuously push back the economic envelope. Every year the previous year's improvements have been evaluated and updated for potential further enhancements and incremental opportunities.
The continuous improvement program to date has resulted in an estimated cost savings of 30% per well with outstanding production performance. The continuous improvement plan for the next 5 years targets even more cost reduction and better production performance after hydraulic fracturing treatments.
This paper provides the reader with an example of an exhaustive program of cost and performance improvement that should apply to most fracturing operations around the globe.