bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organelle‐Targeting Nanoparticles
Authors: Soukar John , Peppas Nicholas A. , Gaharwar Akhilesh K. 
Published: January 2025

AbstractOrganelles are specialized subunits within cells which carry out vital functions crucial to cellular survival and form a tightly regulated network. Dysfunctions in any of these organelles are linked to numerous diseases impacting virtually every organ system in the human body. Targeted delivery of therapeutics to specific organelles within the cell holds great promise for overcoming challenging diseases and improving treatment outcomes through the minimization of therapeutic dosage and off‐target effects. Nanoparticles are versatile and effective tools for therapeutic delivery to specific organelles. Nanoparticles offer several advantageous characteristics, including a high surface area‐to‐volume ratio for efficient therapeutic loading and the ability to attach targeting moieties (tethers) that enhance delivery. The choice of nanoparticle shape, size, composition, surface properties, and targeting ligands depends on the desired target organelle and therapeutic effect. Various nanoparticle platforms have been explored for organelle targeting, such as liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles. In this review, current and emerging approaches to nanoparticle design are examined in the context of various diseases linked to organelle dysfunction. Specifically, advances in nanoparticle therapies targeting organelles such as the nucleus, mitochondria, lysosomes/endosomes, Golgi apparatus, and endoplasmic reticulum are comprehensively and critically discussed.
Organic Photo‐Responsive Piezoelectric Materials Based on Pyrene Molecules for Flexible Sensors
Authors: Song Xinyi , Wang Xiaohui , Liu Wei , Chen Xiaoxue , Li Shaoling , Islam Md Shariful , Li Ling , Zhao Xiaobo , Redshaw Carl , Zhao Yu , Cao Changyong (Chase) , Feng Xing 
Published: January 2025

AbstractDue to the advantages of multiplicity, functionality, and flexibility of organic building blocks, organic piezoelectric materials are regarded as next‐generation materials for potential applications in flexible sensors and energy harvesting devices. Here, a new pure organic pyrene‐based molecule, PyPT is presented, which crystallizes in a non‐centrosymmetric structure. PyPT is synthesized and demonstrated to be suitable for developing flexible sensors due to its remarkable piezoelectric properties. The pyrene‐based piezoelectric molecule exhibits excitation wavelength‐dependent emission behavior and aggregation‐caused quenching properties and demonstrated a piezoelectric coefficient (d33) of 8.02 ± 0.26 pm V−1. The output electronic signal of a PyPT‐based flexible sensor shows a significant increase from 30 to 721 pA as the strain increases from 0.12% to 0.59% with a low Young's modulus of 1.63 Gpa. This high‐performance piezoelectric sensor can serve as a sensitive sound sensor for sound detection and recognition based on the basic characteristics of sound, such as amplitude, frequencies, and timbres. This research offers new insights into advancing pure organic luminescent materials with piezoelectric properties, paving the way for applications in flexible electronics for wearables, human–machine interfaces, and the Internet of Things.
Cost‐effectiveness analysis of postoperative surveillance for stage IV colorectal cancer in Japan: An economic modeling study
Authors: Tsukamoto Fumio , Tsukamoto Shunsuke , Kato Takeharu , Nagata Hiroshi , Takamizawa Yasuyuki , Moritani Konosuke , Kinugasa Yusuke , Esaki Minoru , Kanemitsu Yukihide , Igarashi Ataru 
Published: January 2025

AbstractBackgroundThe optimal postoperative surveillance strategy after curative resection in patients with stage IV colorectal cancer remains unclear. The present study aimed to assess the cost‐effectiveness of postoperative surveillance strategies recommended by the various academic societies for stage IV colorectal cancer after curative resection.MethodsThis economic evaluation used a Markov state‐transition model to compare the cost‐effectiveness of postoperative surveillance programs proposed in guidelines published by the American Society of Clinical Oncology, American Society of Colon and Rectal Surgeons, European Society for Medical Oncology, National Comprehensive Cancer Network, and Japanese Society for Cancer of the Colon and Rectum. Model parameters were extracted from our retrospective data for patients with colorectal cancer who had synchronous liver and/or lung metastases and underwent curative resection. Cost‐effectiveness was assessed using an incremental cost‐effectiveness ratio for quality‐adjusted life years, with a maximum acceptable value of 5 000 000–6 000 000 JPY/33333–40 000 USD. Uncertainty in the model was assessed by probabilistic sensitivity analyses.ResultsFor patients with stage IV colorectal cancer after curative resection, the JSCCR‐strategy was the most cost‐effective, with an incremental cost‐effectiveness ratio of 2 888 628 JPY/19256 USD compared with the next most cost‐effective program. Probabilistic sensitivity analysis showed that the JSCCR‐strategy was most likely to be selected as the most cost‐effective (76.1%–77.9%).ConclusionsThis modeling analysis found that the JSCCR‐strategy was the most cost‐effective strategy for stage IV colorectal cancer. Our findings suggest that intensive postoperative surveillance is acceptable for stage IV colorectal cancer.
Clinical utility of plasma p‐tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease
Authors: Chong Joyce R. , Hilal Saima , Tan Boon Yeow , Venketasubramanian Narayanaswamy , Schöll Michael , Zetterberg Henrik , Blennow Kaj , Ashton Nicholas J. , Chen Christopher P. , Lai Mitchell K. P. 
Published: January 2025

AbstractINTRODUCTIONUsing an Asian cohort with high prevalence of concomitant cerebrovascular disease (CeVD), we evaluated the performance of a plasma immunoassay for tau phosphorylated at threonine 217 (p‐tau217) in detecting amyloid beta positivity (Aβ+) on positron emission tomography and cognitive decline, based on a three‐range reference, which stratified patients into low‐, intermediate‐, and high‐risk groups for Aβ+.METHODSBrain amyloid status (Aβ– [n = 142] vs Aβ+ [n = 73]) on amyloid PET scans was assessed along with the plasma ALZpath p‐tau217 assay to derive three‐range reference points for PET Aβ+ based on 90% sensitivity (lower threshold) and 90% specificity (upper threshold).RESULTSPlasma p‐tau217 (area under the curve [AUC] = 0.923) outperformed routine clinical assessments (AUC = 0.760–0.819; p ≤ 0.003) and other plasma biomarkers (AUC = 0.817–0.834; p < 0.001). The high‐risk group showed significantly higher rates of cognitive decline than the low‐risk group.DISCUSSIONRisk stratification for PET Aβ+ based on a plasma p‐tau217 assay demonstrated potential diagnostic and prognostic utility in an Asian cohort with concomitant CeVD.Highlights
The utility of plasma p‐tau217 to detect brain amyloid beta pathology (Aβ+) was studied in an Asian cohort with concomitant cerebrovascular disease
Plasma tau phosphorylated at threonine 217 (p‐tau217) showed superior utility in detecting Aβ+ compared to neuroimaging measures, clinical workup, or other blood biomarkers including p‐tau181, glial fibrillary protein (GFAP), and Aβ
Higher plasma p‐tau217 correlated with faster cognitive decline
Plasma p‐tau217 shows promise as an Alzheimer's disease (AD) diagnostic and prognostic biomarker in diverse populations
Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's‐related phenotypes
Authors: Feng Yijia , Wang Shengya , Yang Danlu , Zheng Wu , Xia Huwei , Zhu Qinxin , Wang Zhipeng , Hu Bolang , Jiang Xinyi , Qin Xuemei , Ni Chenkang , Pan Wenhao , Zhao Yifan , Pan Sipei , Zhang Yun , Song Weihong 
Published: January 2025

AbstractINTRODUCTIONInterferon‐induced transmembrane protein 3 (IFITM3) modulates γ‐secretase in Alzheimer's Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell‐specific effect on AD remains unclear.METHODSSingle nucleus RNA sequencing (snRNA‐seq) was used to assess IFITM3 expression. Adeno‐associated virus‐BI30 (AAV‐BI30) was injected to reduce IFITM3 expression in the cerebrovascular endothelial cells (CVECs). The effects on AD phenotypes in cells and AD mice were examined through behavioral tests, two‐photon imaging, flow cytometry, Western blot, immunohistochemistry, and quantitative polymerase chain reaction assay (qPCR).RESULTSIFITM3 expression was increased in the CVECs of patients with AD. Overexpression of IFITM3 in primary endothelial cells enhanced Aβ generation through regulating beta‐site APP cleaving enzyme 1 (BACE1) and γ‐secretase. Aβ further increased IFITM3 expression, creating a vicious cycle. Knockdown of IFITM3 in CVECs decreased Aβ accumulation within cerebrovascular walls, reduced Alzheimer's‐related pathology, and improved cognitive performance in AD transgenic mice.DISCUSSIONKnockdown of IFITM3 in CVECs alleviates AD pathology and cognitive impairment. Targeting cerebrovascular endothelial IFITM3 holds promise for AD treatment.Highlights
Interferon‐induced transmembrane protein 3 (IFITM3) expression was increased in the cerebrovascular endothelial cells (CVECs) of patients with Alzheimer's Disease (AD).
Cerebrovascular endothelial IFITM3 regulates amyloid β protein (Aβ) generation through regulating beta‐site APP cleaving enzyme 1 (BACE1) and γ‐secretase.
Knockdown of IFITM3 in CVECs reduces Aβ deposits and improves cognitive impairments in AD transgenic mice.
Cerebrovascular endothelial IFITM3 could be a potential target for the treatment of AD.
Building Three‐Dimensional Complexity by Intramolecular 2‐Aminoallyl Cation−Diene (4+3) Cycloaddition
Authors: Shen Lulu , Qin Tianzhu , Jiao Chongling , Zi Weiwei 
Published: January 2025

AbstractReliable methods for rapidly constructing C(sp3)‐rich three‐dimensional polycycles are in high demand for organic synthesis and medicinal chemistry. Although there are various mature systems for synthesizing five‐ or six‐membered polycycles, a catalytic platform for accessing diverse cycloheptanoid‐containing polycyclic scaffolds is lacking. Herein, we describe a method for copper‐catalyzed intramolecular 2‐aminoallyl cation−diene (4+3) cycloaddition reactions. By using 1,3‐diene‐tethered ethynyl methylene cyclic carbamates as substrates, we were able to construct various cycloheptanoid‐containing polycyclic scaffolds, which are present in many bioactive molecules. The cycloaddition products were rich in functionality that could undergo various chemical transformations. The synthetic utility of the method was illustrated by total synthesis of the natural products (±)‐mint ketone and (±)‐aphanamol I. Mechanistic studies indicated that the cycloadditions proceed by a concerted [4π+2π] mechanism and that an endo‐selective pathway is favored.
A Metastable State Facilitates Low Temperature CO Oxidation over Pt Nanoparticles
Authors: Le Samantha L. , O'Connor Christopher R. , Kim Taek‐Seung , Reece Christian 
Published: January 2025

AbstractThe dynamic response of heterogeneous catalytic materials to their environment opens a wide variety of possible surface states which may have increased catalytic activity. In this work, we find that it is possible to generate a surface state with increased catalytic activity over metallic 2 nm Pt nanoparticles by performing a thermal treatment of the CO*‐covered Pt catalyst. This state is characterised by its ability to oxidise CO to CO2 at room temperature. By combining pressure pulse experiments with in situ spectroscopy we correlate the formation of this high‐activity state with the desorption of weakly bound CO* molecules from well‐coordinated Pt sites. This high‐activity state is metastable, degrading after elevated thermal treatments or upon readsorption of CO at room temperature. We conclude that this metastable state is highly localised to the surface of the nanoparticle, however its exact atomic structure remains open to speculation.
Fluorescent Artificial Receptor for Dopamine based on Molecular Recognition‐driven Dynamic Covalent Chemistry in a Lipid Nanoreactor
Authors: Kozibroda Bohdan , Lehn Jean‐Marie , Klymchenko Andrey S. 
Published: January 2025

AbstractMolecular recognition and detection of small bioactive molecules, like neurotransmitters, remain a challenge for chemists, whereas nature found an elegant solution in the form of protein receptors. Here, we introduce a concept of a dynamic artificial receptor that synergically combines molecular recognition with dynamic imine bond formation inside a lipid nanoreactor, inducing a fluorescence response. The designed supramolecular system combines a lipophilic recognition ligand derived from a boronic acid, a fluorescent aldehyde based on push‐pull styryl pyridine and a phenol‐based catalyst. The recognition ligand specifically captures dopamine inside lipid nanodroplets and thus triggers imine bond formation with the aldehyde, producing the emission color change. The rational design of the fluorescent aldehyde, the catalyst, and the recognition ligand allows dramatic acceleration of the imine bond formation required for rapid sensing of dopamine. The nanoprobe enables dopamine detection with micromolar sensitivity and singe‐nanoprobe imaging of dopamine gradients through its robust two‐color ratiometric response. It displays remarkable selectivity without the interference of competing biogenic primary amines and biological media: blood serum, plasma, urine and cell lysate. The proposed concept of a dynamic artificial receptor offers a solution to the long‐standing problem of molecular recognition and sensing of small molecules in complex biological media.
Mn‐Doped Ni(OH)2 Nanosheets as High‐Performance Electrocatalyst for 5‐Hydroxymethylfurfural Electrooxidation
Authors: Xu Hui , Wang Wenke , Sang Ting , Hao Jingcheng , Zhang Xiaoyu , Li Zhonghao 
Published: January 2025

AbstractConverting 5‐hydroxymethylfurfural (HMF) to 2,5‐furandicarboxylic acid (FDCA) via electrooxidation is a sustainable approach for generating high‐value chemicals from biomass. This study presents Mn‐doped Ni(OH)2 nanosheets as an effective electrocatalyst for HMF electrooxidation. The Mn‐doped Ni(OH)2 nanosheets were synthesized through a microwave‐assisted deep eutectic solvent (DES) strategy, followed by an alkaline reflux process. The as synthesized Mn‐doped Ni(OH)2 nanosheets demonstrated remarkable catalytic performance, achieving 100 % HMF conversion, 99.0 % FDCA yield, and 98.8 % Faraday efficiency. Analysis using X‐ray photoelectron spectroscopy (XPS), open circuit potential (OCP), and density functional theory (DFT) revealed that Mn doping induced surface charge redistribution and electron hole formation, enhancing HMF adsorption and facilitating its oxidation. This study not only elucidates the role of Mn doping in Ni(OH)2 catalyst for HMF electrooxidation but also introduces an efficient electrocatalyst for biomass conversion.
Zum abschnittsweisen Rückbau von Betonbrücken mit spannungsrisskorrosionsempfindlichem Spannstahl
Authors: Wetzel Timm , Albrecht Felix 
Published: January 2025

AbstractDie rechnerische Nachweisführung der Rückbauzustände von Großbrücken, die mit Spannstahl errichtet wurden, der gegenüber Spannungsrisskorrosion empfindlich ist, stellt eine besondere Herausforderung dar. Insbesondere die Beantwortung der Frage nach den noch ansetzbaren Restspannstahlflächen sowie ein darauf abgestimmtes Rückbaukonzept sind entscheidend für einen störungsfreien Bauablauf. In der vorliegenden Arbeit wird ein wahrscheinlichkeitstheoretischer Ansatz vorgestellt, mit dessen Hilfe die mit ausreichender Sicherheit ansetzbaren Restspannstahlflächen bestimmt werden können. Einhergehend mit den weiterhin unterbreiteten Vorschlägen soll hiermit ein Beitrag zu einer rechtssicheren Planung und letztlich zur Ausschreibung von Brückenrückbauten geleistet werden.
Crystal structure and photoluminescence properties of CuBrxI1−x(melamine) (0 ≤ x ≤ 1) complexes
Authors: Kim Juhyun , Kim Donghyeon , Khefif Fouzia , Yoon Woojin , Yun Hoseop , Yoo Chung‐Yul , Kim Seung‐Joo 
Published: January 2025

AbstractOrganic–inorganic copper(I) halide complexes have attracted attention due to their optoelectronic properties and non‐toxic nature. In this study, we systematically synthesized copper(I) halide melamine complexes as single crystals, (CuBr(melamine) and CuI(melamine)) and polycrystalline powders, CuBrxI1‐x(melamine) (0 ≤ x ≤ 1). The crystal structures of CuBr(melamine) and CuI(melamine) are isotypic with a triclinic space group P , where copper(I) is connected with three adjacent halides along the a‐axis and a single melamine ligand along the c‐axis, forming an infinite stair‐chain structure. The photoluminescence emission peaks of CuBrxI1‐x(melamine) (0 ≤ x ≤ 1) show a red shift from 455 nm to 520 nm with the substitution of Br for I. This finding explains the structure–property relationship of organic–inorganic copper(I) halide complexes and provides guidelines for developing new organic–inorganic optoelectronic materials.
Further Disadvantages of Socioeconomic Status: The Role of Subjective Social Status in University Students' Sense of Belonging
Authors: Fernandez Daniela , Wong Chuk Yan , Bedford Summer , Oliveria‐Silva Ligia , Begeny Christopher , Ryan Michelle 
Published: January 2025

ABSTRACTAttention has been given to increasing the sense of belonging of students from disadvantaged socioeconomic groups in higher education (HE). Research in belonging has focused on objective indicators of socioeconomic status (SES; i.e., educational status, household income), yet focus on subjective socioeconomic status (SSS) is more limited. We address this gap in two studies, including a cross‐sectional survey (N = 503) and semi‐structured interviews (N = 16), to address two questions: (a) to what extent SSS and a sense of belonging are associated; and (b) what are the social identity processes that might help to explain the relationship between SSS and belonging. As expected, SSS was positively associated with a sense of belonging, such that higher SSS was associated with higher levels of a sense of belonging. Together, these studies illustrate that SSS (a) is yet another way that SES operates to benefit some and disadvantage others; (b) provides an opportunity to analyse the role of intergroup relations in individuals' experiences and (c) is interlocked with intersectional identities, such as ethnicity and race.
Flavonoids and Kavalactones Isolated From Seeds of Alpinia katsumadai Hayata and Their Cytotoxic Activities
Authors: Zhao Xin‐Man , You Hua‐Lin , Yang Lan , Zhou Bo , Su Kang‐Mei , Gajendran Babu , Shen Xiang‐Chun , Zhang Nen‐Ling 
Published: January 2025

ABSTRACTAn unrevealed dihydroflavone‐monoterpene conjugate (1), 2 unrevealed kavalactones (2 and 3, including 1 with an uncommon side chain), and 13 previously identified compounds (4–16) were extracted from Alpinia katsumadai Hayata seeds. The two‐dimensional structures of the new compounds were authenticated utilizing HRESIMS as well as NMR spectral analysis, whereas their absolute chiral configurations were ascertained either by correlating the experimental and simulated values of electronic circular dichroism (ECD) patterns or conducting x‐ray diffraction experiments. Compounds 2–5, 9, 11, and 14 were assessed for their capacity to impede the growth of cancer cells of A549, HepG2, SGC7901, and SW480 using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. Compounds 3 and 4 demonstrated antiproliferative activity with IC50 ranges of 3.94–21.78 µM, whereas the other compounds exhibited no significant cytotoxicity.
Systematic Review and Meta‐Analysis of the Super High‐Pressure Balloon (SIS‐OPN) for Percutaneous Coronary Intervention
Authors: Kumar Sant , Jalli Sandeep , Sandoval Yader , Alaswad Khaldoon , Patel Nachiket J. , Henry Tim , Doshi Darshan , Pershad Ashish , Seto Arnold , Kumar Gautam , Burke M. Nicholas , Brilakis Emmanouil S. 
Published: January 2025

ABSTRACTIntroductionThe super high‐pressure NC balloon (OPN NC; SIS Medical AG, Winterthur, Switzerland) is increasingly used in percutaneous coronary intervention (PCI). We performed a systematic review and meta‐analysis of its efficacy and safety.MethodsA systematic review was conducted using PubMed and the Cochrane Library to identify studies using the OPN NC balloon in PCI. Procedural success, major adverse cardiac events (MACE), coronary perforation, and other complications were pooled using weighted means, confidence intervals (CI), and I² statistics for heterogeneity assessment.ResultsTwenty‐nine studies (5 prospective including 2 randomized‐controlled trials, 12 retrospective, and 12 case reports) were included in the systematic review, of which 11 (3 prospective, 8 retrospective) were included in the meta‐analysis. Of the 1015 meta‐analysis patients, 50.7% presented with stable angina and 21.6% with an acute coronary syndrome. Mean lesion length was 22.8 ± 13.7 mm, the prevalence of moderate or severe calcification was 93.7%, and 40.4% of lesions were in‐stent. Procedural success was 95.1% (95% CI 89.3%−98.8% with significant heterogeneity: I² = 84.9%). The incidence of periprocedural MACE was 1.9% (95% CI 1.1%−2.8%, I² 86.9%), and the incidence of coronary perforation was 0.6% (95% CI 0.3%−1.5%, I² 87.2%).ConclusionsUse of the OPN NC balloon is associated with high success and acceptable complication rates. The heterogeneity of outcomes underscores the need for additional studies and standardized definitions.
Evaluating the breadmaking potential of wholemeal flours from einkorn, emmer, and spelt grown in the Canadian prairies
Authors: Valsalan Anashwar , Hucl Pierre , Malalgoda Maneka 
Published: January 2025

AbstractBackground and ObjectivesAncient grains like einkorn, emmer, and spelt remain underutilized and underexplored, limiting their market potential. This study evaluates the chemical composition, rheology, pasting, and baking properties of spring growth habit einkorn, emmer, and spelt cultivars grown in the Canadian prairies compared to wholemeal and refined hexaploid wheat.FindingsEinkorn cultivars (CDC Aixe and CDC Marval) had inferior dough mixing properties and the lowest bread loaf volume. CDC Tatra (emmer) bread had a significantly (p < .05) higher specific volume (3.32 mL/g) than Canada Western Red Spring (CWRS) wholemeal bread.ConclusionsResults from mixing and baking indicate that emmer and spelt cultivars have the potential to be used in breadmaking applications, while einkorn cultivars with suboptimal properties need ingredient technology and process modifications to improve their functionalities.Significance and NoveltyThe study was able to identify and characterize an emmer cultivar (CDC Tatra) with excellent mixing and baking properties having the potential as a standalone flour for baking applications. This represents a significant advancement, as prior research had not recognized any emmer cultivars for their suitability in baking. Our results highlight that cultivar‐based assessment is essential in evaluating the end‐use quality of ancient grain species, thereby developing products using such underutilized grains.