bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort profile: The Vitality 90+ Study—a cohort study on health and living conditions of the oldest old in Tampere, Finland
Authors: Enroth Linda , Halonen Pauliina , Tiainen Kristina , Raitanen Jani , Jylhä Marja 
Published: February 2023

PurposeVitality 90+ is an ongoing population-based study with repeated cross-sectional data collections. The study was designed to examine trends in health, functioning, living conditions, quality of life and care needs among the oldest old in Finland.ParticipantsNine mailed surveys have been conducted in the city of Tampere between 1995 and 2018. The first three surveys in 1995, 1996 and 1998 included all community-dwelling individuals aged 90 years or older; and the following six surveys in 2001, 2003, 2007, 2010, 2014 and 2018 covered all individuals in Tampere regardless of their living arrangements. In total, the surveys have included 5935 participants (8840 observations). Around 80% of the participants have been women. The participants’ age range has been between 90 and 107 years.Findings to dateThe surveys have consistently asked the same questions over time, covering basic sociodemographic factors, morbidity, functioning, self-rated health (SRH), living arrangements, social relations, quality of life, care needs and providers of care. Survey data have been linked with national register data on health and social service use, mortality and medication. The main findings regarding the time trends show an increase in the proportion of people independent in activities of daily living and mobility. Along with improved functioning, the number of chronic conditions has increased, and SRH has shown a tendency to decline. In addition, we have found increasing occupational class inequalities in functioning and SRH over time.Future plansThe next round of data collection will be completed by the end of 2022. The Vitality 90+ Study welcomes research collaborations that fall within the general aims of the project. The research data 1995–2014 are archived at the Finnish Social Science Data Archive and the data for years 2018 and 2022 will be archived in 2023.
Connections Lab: a case study exploring a web-based innovation designed to advance shared risk and protective factor approaches to preventing injuries and violence
Authors: Porter Jamila M , Robinson Ina , Roberts Carly , Zavala Claudia 
Published: February 2023

BackgroundInjuries and violence share many of the same risk and protective factors, which are rooted in the social determinants of health (SDOH) and the social determinants of equity. Addressing shared risk and protective factors (SRPFs)—common factors that make it more or less likely that a population will experience injuries or violence—is critical prevention efforts. The Safe States Alliance created the Connections Lab—a suite of web-based resources to help injury and violence prevention public health practitioners and their partners understand, describe, implement and evaluate SRPF approaches.DesignA mixed-methods approach using the Diffusion of Innovation Theory assessed how the Connections Lab influenced users’ knowledge, abilities and work related to SRPF approaches. A web-based survey was administered to 234 participants in April–May 2021. Semistructured virtual group discussions were conducted with a subset of 15 survey respondents who volunteered to participate.ResultsThe case study revealed three key findings. The Connections Lab: was diffused among practitioners across sectors within and outside of public health; it increased practitioners’ perceived proficiency across 10 skill sets related to describing, planning, implementing and evaluating SRPF approaches; and it increased understanding of the importance of upstream and structural drivers of injuries and violence.ConclusionThe Connections Lab was a critical first step to expand the definition of SRPF approaches, connect SRPFs to concepts of equity and the SDOH, and provide strategies for engaging partners in public health and across other sectors in SRPF approaches.
Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer
Authors: Boucher Yves , Posada Jessica M. , Subudhi Sonu , Kumar Ashwin S. , Rosario Spencer R. , Gu Liqun , Kumra Heena , Mino-Kenudson Mari , Talele Nilesh P. , Duda Dan G. , Fukumura Dai , Wo Jennifer Y. , Clark Jeffrey W. , Ryan David P. , Fernandez-Del Castillo Carlos , Hong Theodore S. , Pittet Mikael J. , Jain Rakesh K. 
Published: February 2023

AbstractPurpose:Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechanisms of benefit by assessing the effects of neoadjuvant LOS on the tumor microenvironment.Experimental Design:We performed a gene expression and immunofluorescence (IF) analysis using archived surgical samples from patients treated with LOS+FFX+CRT (NCT01821729), FFX+CRT (NCT01591733), or surgery upfront, without any neoadjuvant therapy. We also conducted a longitudinal analysis of multiple biomarkers in the plasma of treated patients.Results:In comparison with FFX+CRT, LOS+FFX+CRT downregulated immunosuppression and pro-invasion genes. Overall survival (OS) was associated with dendritic cell (DC) and antigen presentation genes for patients treated with FFX+CRT, and with immunosuppression and invasion genes or DC- and blood vessel–related genes for those treated with LOS+FFX+CRT. Furthermore, LOS induced specific changes in circulating levels of IL-8, sTie2, and TGF-β. IF revealed significantly less residual disease in lesions treated with LOS+FFX+CRT. Finally, patients with a complete/near complete pathologic response in the LOS+FFX+CRT–treated group had reduced CD4+FOXP3+ regulatory T cells (Tregs), fewer immunosuppressive FOXP3+ cancer cells (C-FOXP3), and increased CD8+ T cells in pancreatic ductal adenocarcinoma lesions.Conclusions:Adding LOS to FFX+CRT reduced pro-invasion and immunosuppression–related genes, which were associated with improved OS in patients with LAPC. Lesions from responders in the LOS+FFX+CRT–treated group had reduced Tregs, decreased C-FOXP3 and increased CD8+ T cells. These findings suggest that LOS may potentiate the benefit of FFX+CRT by reducing immunosuppression.
Cardiovascular Risk Stratification by Automatic Coronary Artery Calcium Scoring on Pretreatment Chest Computed Tomography in Diffuse Large B-Cell Lymphoma Receiving Anthracycline-Based Chemotherapy: A Multicenter Study
Authors: Shen Hesong , Lian Yanbang , Yin Jinxue , Zhu Minghong , Yang Chun , Tu Chunrong , Peng Yangling , Li Xiaoqin , Zhang Jiuquan 
Published: February 2023

Background:
Balancing the cardiovascular risk and benefit of anthracycline-based chemotherapy in patients with diffuse large B-cell lymphoma is an important clinical issue. We aimed to evaluate whether the pretreatment coronary artery calcium score (CACS) can stratify the risk of cancer therapy-related cardiac dysfunction (CTRCD) and major adverse cardiovascular events (MACEs) in patients with diffuse large B-cell lymphoma receiving anthracycline-based chemotherapy.

Methods:
The patients with diffuse large B-cell lymphoma from 4 hospitals were retrospectively enrolled. The CACS was automatically calculated on nongated chest computed tomography before treatment using artificial intelligence-CACS software and divided into 3 categories (0, 1–100, and >100). The associations between the CACS and CTRCD and between the CACS and MACEs were assessed by logistic regression and Fine-Gray competing-risk regression model. Nelson–Aalen cumulative risk curve was performed to assess the cumulative incidence of MACEs.

Results:

A total of 1468 patients (785 men and 683 women; 100% Asian) were enrolled, and 362 and 185 patients developed CTRCD and MACEs, respectively. Compared with a CACS of 0 (n=826), there was stepwise higher odds of CTRCD with a CACS between 1 and 100 (n=356; odds ratio, 2.587) and a CACS >100 (n=286; odds ratio, 5.239). The CACS was associated with MACEs (1–100 versus 0: subdistribution hazard ratio 3.726; >100 versus 0: subdistribution hazard ratio 7.858; all
P
<0.001). Competing risk-adjusted MACEs rates for patients with a CACS of 0, 1 to 100, and >100 were 1.21%, 8.43%, and 11.19%, respectively, at 3 years, and 3.27%, 16.01%, 31.12%, respectively, at 5 years.

Conclusions:
The automatic CACS derived from chest computed tomography before treatment was helpful to identify high-risk patients of CTRCD and MACE and guide clinicians to implement cardiovascular protection strategies in patients with diffuse large B-cell lymphoma who received anthracycline-based chemotherapy.
Cyber versus Brick and Mortar: Achievement, Attainment, and Postsecondary Outcomes in Pennsylvania Charter High Schools
Authors: Cordes Sarah A. 
Published: February 2023

Abstract
The charter school sector has expanded beyond brick-and-mortar schools to cyber schools, where enrollment grew almost tenfold between 2015 and 2020. While a large literature documents the effects of charter schools on test scores, fewer studies explore impacts on attainment or postsecondary outcomes and there is almost no work exploring the consequences of cyber charter enrollment for these outcomes. In this paper, I examine the impacts of Pennsylvania's charter high schools on student attendance, achievement, graduation, and postsecondary enrollment, distinguishing the impacts of brick-and-mortar from cyber schools. I find that brick-and-mortar charters have no or positive effects across outcomes, and that effects are concentrated in urban districts and among Black and economically disadvantaged students. By contrast, attending a cyber charter is associated with almost universally worse outcomes, with little evidence of heterogeneity. Students who enroll in a cyber charter at the beginning of ninth grade are 9.5 percentage points (pp) less likely to graduate, 16.8 pp less likely to enroll in college, and 15.2 pp less likely to persist in a postsecondary institution beyond one semester. These results suggest that additional regulation and oversight of cyber charter schools is warranted and also bring into question the efficacy of online education.
Endogenous Firm Competition and the Cyclicality of Markups
Authors: Afrouzi Hassan , Caloi Luigi 
Published: February 2023

Abstract
We show that the cyclicality of output growth is a sufficient predictor for the cyclicality of markups in models that micro-found variable markups through dynamic trade-offs. We use data on markups from the U.S. as well as survey data on firms’ expectations from New Zealand to test the predictions of these models and find evidence in favor of their mechanisms. Finally, we study the implications of these mechanisms for cyclicality of markups in a calibrated general equilibrium model. In particular, we find that the degree of hump-shaped response in output is crucial for the direction of aggregate markup cyclicality.
Measuring Group Cohesion to Reveal the Power of Social Relationships in Team Production
Authors: Gächter Simon , Starmer Chris , Tufano Fabio 
Published: February 2023

Abstract
We introduce group cohesion to study the economic relevance of social relationships in team production. We operationalize measurement of group cohesion, adapting the “oneness scale” from psychology. A series of experiments, including a preregistered replication, reveals strong, positive associations between group cohesion and performance assessed in weak-link coordination games, with high-cohesion groups being likely to achieve superior equilibria. In exploratory analysis, we identify beliefs rather than social preferences as the primary mechanism through which factors proxied by group cohesion influence group performance. Our evidence provides proof of concept for group cohesion as a useful tool for economic research and practice.
Low-Quality Seeds, Labor Supply and Economic Returns: Experimental Evidence from Tanzania
Authors: Bulte Erwin , Di Falco Salvatore , Kassie Menale , Vollenweider Xavier 
Published: February 2023

Abstract
Low productivity in agriculture is a major cause of poverty and food insecurity in Africa. One explanation for low productivity is the widespread presence of low-quality inputs on local markets (“lemon technologies”), which causes uncertainty among farmers and erodes incentives for adoption. We report the results from a field experiment in Tanzania to study the impact of improved maize seeds in a context where we exogenously vary seed quality and uncertainty about seed type. The analysis is at the level of experimental plots owned and managed by farmers (not the entire farm). While improved seed positively affects harvests and reduces the probability of crop failure among fully-informed farmers, these benefits are attenuated significantly when farmers are uncertain about the seed type they receive. The main channel linking uncertainty to lower harvest levels is the re-allocation of labor—a complementary input. The presence of lemon inputs on the market for modern inputs impedes learning about the profitability of these inputs and increases the yield gap by slowing down adoption in subsequent periods.
Subsidy Phase-Out and Consumer Demand Dynamics: Evidence from the Battery Electric Vehicle Market in China
Authors: Hu Yunyi , Yin Haitao , Zhao Li 
Published: February 2023

Abstract
This article quantifies the impact of the battery electric vehicle subsidy program in China. We build a structural model of dynamic demand and Bertrand Nash supply to study price elasticity and changes in production costs. The model highlights four channels through which the subsidy program impacts the market: temporal elasticity, in response to a current price change; intertemporal elasticity, in response to a future price change; and multiplication effects through peer and learning by doing. Combining these estimates, we simulate outcomes under four subsidy schemes and find a phase-out policy could be the most cost-effective while achieving higher sales promotion compared with alternative policies that provide larger subsidies over more prolonged periods.
Cellular mechanisms of the lufenuron growth regulator in adults of Anthonomus grandis (Coleoptera: Curculionidae)
Authors: dos Santos Cruz Glaucilane , Teixeira Valeria Wanderley , da Nobrega Ferreira Maria Clara , da Costa Hilton Nobre , de Melo Ismaela Maria Ferreira , Guedes Carolina Arruda , Filho Leucio Duarte Vieira , Neto Clovis José Cavalcanti Lapa , Teixeira Álvaro Aguiar Coelho 
Published: February 2023

Abstract
Growth-regulating insecticides are used for several cotton pests when immature, and although not registered for Anthonomus grandis, their use causes a satisfactory population reduction in adults. However, it is not known which mechanisms are involved in this reduction. Thus, we studied which tissue and cellular changes may be involved in this process. Adults were fed with flower buds treated with lufenuron (4 ml commercial product /l) for 24 h. Then, the histology of the gonads, oxidative stress and apoptosis were evaluated after periods of 24 h and 48 h. Our study revealed that lufenuron activates the oxidative stress pathway in A. grandis, causing significant changes at the cellular level. These changes may have been caused by stimulation of the production of oxygen ions, free radicals and hydrogen peroxides, resulting in an increase in lipid peroxidation 48 h after treatment. These effects were confirmed by the presence of histopathologies in the gonads of this pest such as disorganization of the follicular cell epithelium, reduction of the yolk, disappearance of the germinal vesicle, reduction of sperm bundles and cysts. Such alterations injured the gonads and impaired tissue homeostasis. It is concluded that together these factors lead to a desirable population reduction when it comes to managing the pest in the field, because the aim is to keep it below the control level. In addition to this desired effect, it is worth noting that lufenuron is safer when compared to other commonly used products, another feature that makes its use quite interesting.
Assisting physicians who exhibit disruptive behavior: Understanding the costs, contributors, and corrections
Authors: Williams Betsy W , Welindt Dillon 
Published: February 2023

Objective The aim of this article is to discuss the etiology, prevalence, impact, and management of disruptive behavior in physicians. These various aspects will be examined at both the individual and system level, to provide appropriate perspective and detail effective approaches to address these behaviors. Method Clinical experience and review of the authors’ and other researchers’ findings provide consensus on numerous key aspects of physician disruptive behavior. Results Physicians demonstrating disruptive behavior are often distressed. The behavior should be understood as arising from biopsychosocial contributors, knowledge gaps, insight, and systems factors. These contributors are inclusive and may interact with each other. Conclusions A comprehensive approach is required which can include assessment/reassessment tools, individualized programming (therapy, coaching, instruction), deliberate practice, medical follow-up, and system intervention. Complications include the diversity of disruptive behaviors, the many contributory factors therein, disagreement about methodology/measurement, and the role of the system.
A 2D lightweight instrumented wheel for assessing wheelchair functionality/activity
Authors: Togni Reto , Müller Manuel , Plüss Stefan , Taylor William R , Zemp Roland 
Published: February 2023

Introduction Force measurement wheels are essential instruments for analysing manual wheelchair propulsion. Existing solutions are heavy and bulky, influence propulsion biomechanics, and are limited to confined laboratory environments. In this paper, a novel design for a compact and lightweight measurement wheel is presented and statically validated. Methods Four connectors between the push-rim and wheel-rim doubled as force sensors to allow the calculation of tangential and radial forces as well as the point of force application. For validation, increasing weights were hung on the push-rim at known positions. Resulting values were compared against pre-determined force components. Results The implemented prototype weighed 2.1 kg and was able to transmit signals to a mobile recording device at 140 Hz. Errors in forces at locations of propulsive pushes were in the range up to ±3.1 N but higher at the frontal extreme. Tangential force components were most accurate. Conclusion The principle of instrumenting the joints between push-rim and wheel-rim shows promise for assessing wheelchair propulsion in daily life.
Is ultra-thin Descemet stripping automated endothelial keratoplasty a viable alternative to Descemet membrane endothelial keratoplasty? A systematic review and meta-analysis
Authors: Singh Tanu , Ichhpujani Parul , Singh Rohan Bir , Arya Sudesh , Kumar Suresh 
Published: February 2023

Background: Ultra-thin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) is a recently developed surgical procedure that has shown promising results for the management of various corneal endothelial diseases. Objectives: To evaluate the outcomes of the UT-DSAEK to the Descemet membrane endothelial keratoplasty (DMEK). Design: A systematic analysis of the studies comparing UT-DSAEK with DMEK by evaluating one or more outcomes (vision, complications, and post-operative endothelial cell counts) was performed. The meta-analysis was done if two or more studies reported a common outcome. Methods: We used PubMed, EMBASE, and SCOPUS databases to identify articles comparing the outcomes of UT-DSAEK with DMEK and performed a meta-analysis using RevMan, version 5.4. Results: A total of six studies were included in this review (two randomized clinical trials and four non-randomized comparative studies). Our analysis showed the patients who underwent DMEK cases showed better visual outcomes with a mean difference of 0.06 LogMAR (95% CI: 0.04–0.09) in BCVA, albeit with i2 of 52% (heterogenous values). The evidence was weak, with the most weightage on retrospective studies. UT-DSAEK showed significantly fewer complications such as graft dislocations, with an odds ratio of 0.25 (95% CI: 0.13–0.48). There was no significant difference in the endothelial cell counts with a mean difference of 86.34 (95%CI: –133.09 to –305.77). Conclusion: Although the literature is limited on UT-DSAEK with post-operative visual acuity that could be practically at par with DMEK, lesser complication rates and comparable post-operative endothelial cells could be a suitable alternative to DMEK for corneal endothelial pathologies.
Transcriptome analysis of Citrus limon infected with Citrus yellow vein clearing virus
Authors: Bin Yu , Zhang Qi , Su Yue , Wang Chunqing , Jiang Qiqi , Song Zhen , Zhou Changyong 
Published: February 2023

Abstract
Background
Citrus yellow vein clearing virus (CYVCV) is the causative agent of citrus yellow vein clearing disease, and poses a serious threat to the lemon industry in Asia. The common symptoms of CYVCV-infected lemon plants are leaf crinkling, leaf chlorotic mottling, and yellow vein clearing. However, the molecular mechanisms underlying CYVCV-citrus interaction that responsible for symptom occurrence is still unclarified. In this study, RNA-seq was performed to analyze the gene expression patterns of ‘Eureka’ lemon (Citrus limon Burm. f.) plants in response to CYVCV infection.

Results
There were 3691 differentially expressed genes (DEGs) identified by comparison between mock and CYVCV-infected lemon plants through RNA-seq. Bioinformatics analyses revealed that these DEGs were components of different pathways involved in phenylpropanoid biosynthesis, brassinosteroid biosynthesis, flavonoid biosynthesis and photosynthesis. Among these, the DEGs related to phytohormone metabolism and photosynthesis pathways were further enriched and analyzed. This study showed that different phytohormone-related genes had different responses toward CYVCV infection, however almost all of the photosynthesis-related DEGs were down-regulated in the CYVCV-infected lemon plants. The obtained RNA-seq data were validated by RT-qPCR using 12 randomly chosen genes, and the results of mRNA expression analysis were consistent with those of RNA-seq.

Conclusions
The phytohormone biosynthesis, signaling and photosynthesis-related genes of lemon plants were probably involved in systemic infection and symptom occurrence of CYVCV. Notably, CYVCV infection had regulatory effects on the biosynthesis and signaling of phytohormone, which likely improve systemic infection of CYVCV. Additionally, CYVCV infection could cause structural changes in chloroplast and inhibition of photosynthesis pathway, which probably contribute to the appearance of leaf chlorotic mottling and yellow vein clearing in CYVCV-infected lemon plants. This study illustrates the dynamic nature of the citrus-CYVCV interaction at the transcriptome level and provides new insights into the molecular mechanism underlying the pathogenesis of CYVCV in lemon plants.