bluuebunny/crossref_metadata_2025_split huggingface dataset:
Content and sentiment analysis of gabapentinoid‐related tweets: An infodemiology study
Authors: Mathieson Stephanie , O'Keeffe Mary , Traeger Adrian C. , Ferreira Giovanni E , Abdel Shaheed Christina 
Published: December 2022

AbstractIntroductionThe increasing number of gabapentinoid (pregabalin and gabapentin) harms, including deaths observed across countries is concerning to health‐care professionals and policy makers. However, it is unclear if the public shares these concerns. This study aimed to describe posts related to gabapentinoids, conduct a content analysis to identify common themes and describe adverse events or symptoms.MethodsKeywords of ‘pregabalin’ or ‘Lyrica’ or ‘gabapentin’ or ‘Neurontin’ were used to search for related tweets posted by people in the community between 8 March and 7 May 2021. Eligible tweets included a keyword in the post. We extracted de‐identified data which included descriptive data of the total number of posts over time; and data on individual tweets including date, number of re‐tweets and post content. Data were exported separately for pregabalin‐ and gabapentin‐related tweets. A 20% random sample was used for the thematic analysis.ResultsThere were 2931 pregabalin‐related tweets and 2736 gabapentin‐related tweets. Thematic analysis revealed three themes (sharing positive experiences and benefits of taking gabapentinoids, people voicing their negative experiences, and people seeking opinions and sharing information). Positive experiences of gabapentinoids were related to sharing stories and giving advice. This was contrasted to negative experiences including ineffectiveness, withdrawals, side effects and frustration related to cost and insurance coverage. Brain fog was the most common adverse symptom reported. Gabapentinoid‐related deaths were only mentioned in three tweets.DiscussionThe increasing public health concern of gabapentinoid‐related deaths was not translated to Twitter discussions.
Sustainable development in equine anaesthesia
Authors: Haseler Callum J. , West Eleanor , Louro Luís Filipe , Petruccione Ilaria , White Kate L. , Pierce J. M. Tom 
Published: December 2022

AbstractClimate change is ‘the biggest global health threat of the 21st century’, and healthcare provision itself comes at an environmental cost. Volatile anaesthetic agents are potent greenhouse gases, but emissions arising from these waste anaesthetic gases can be dramatically reduced through a number of simple actions. This editorial lays out the options for more sustainable equine anaesthesia.
Social influences predicting involvement in couple relationship education
Authors: Totura Garrison Christine M. W. , Neely Daniel , McGill Julianne , Adler‐Baeder Francesca 
Published: December 2022

AbstractObjectiveThis study explored the implementation climate of couple relationship education (CRE), specifically the positive role intimate partners, group members, and program facilitators have on one's beneficial involvement in programming.BackgroundFor CRE programs to be effective, participants need to be actively involved, yet little is known about social influences in the program encouraging participation in CRE. The perceived involvement of influential others was expected to moderate the relationship between intentions to participate and actual CRE involvement, with this involvement related to improvements in marital quality.MethodParticipants (584 men; Mage = 38.9 years and 627 women; Mage = 36.4 years) completed online surveys assessing study variables pre‐ and post‐CRE programming.ResultsPerceived intimate partner involvement contributed to better individual involvement and relationship quality for women with low intentions to participate in CRE, whereas both perceived partner and group involvement tended to have a protective effect for men's involvement.ConclusionThis study primarily demonstrates the importance of the perception of one's intimate partner's involvement in predicting individual involvement in CRE programs.ImplicationsDetermining predictors of program involvement assists with understanding the context of CRE effectiveness and skill acquisition for those intended to benefit.
Ferulic acid improves glucose homeostasis by modulation of key diabetogenic activities and restoration of pancreatic architecture in diabetic rats
Authors: Salau Veronica F. , Erukainure Ochuko L. , Olofinsan Kolawole O. , Bharuth Vishal , Ijomone Omamuyovwi M. , Islam Md. Shahidul 
Published: December 2022

AbstractThere are increasing concerns on the rising cases of diabetes mellitus with type 2 diabetes (T2D) being of major interest as well as the cost of its treatment. Plant phenolic compounds are natural and potent antioxidants that have been widely reported for their antidiabetic activities properties, one of which is ferulic acid. The effect of ferulic acid (FA) on major diabetogenic activities and pancreatic architecture linked to T2D was investigated in T2D rats. T2D was induced in male Sprague–Dawley rats using the fructose‐streptozotocin model. Diabetic rats were treated with FA at 150 or 300 mg/kg bodyweight (bw). Normal control consisted of rats administered with food and water, while diabetic control consisted of untreated diabetic rats. Metformin was used as the standard drug. The rats were humanely sacrificed after 5 weeks of treatment. Their blood, liver, and pancreas were collected for analysis. Total glycogen content and carbohydrate metabolic enzymes activities were analyzed in the liver, while the pancreas and serum from blood were analyzed for oxidative stress biomarkers, purinergic and cholinergic enzyme activities, and amylase and lipase activities. The pancreatic tissue was further subjected to microscopic and histological examinations. FA caused a significant (p < 0.05) decrease in blood glucose level, with concomitant increase in serum insulin level. Treatment with FA also led to elevated levels of GSH, HDL‐c, SOD, and catalase activities, while concomitantly suppressing malondialdehyde, cholesterol, triglyceride, LDL‐c, NO, ALT, AST, creatinine, urea, and uric acid levels, acetylcholinesterase, ATPase, ENTPDase, 5′‐nucleotidase, lipase, glycogen phosphorylase, glucose‐6‐phosphatase, and fructose‐1,6‐biphosphatase activities. Histology analysis revealed an intact pancreatic morphology in FA‐treated diabetic rats. While transmission electron microscopy (TEM) analysis revealed an intact pancreatic ultrastructure and increased number of insulin granules in β‐cells. Taken together, these results portray that the antidiabetic potentials of ferulic acid involves modulation of major diabetogenic activities and maintenance of the pancreatic ultrastructure architecture.
Cost‐utility analysis of emicizumab for the treatment of severe hemophilia A patients in Canada
Authors: Yu Jacky K. , Wong William W. L. , Keepanasseril Arun , Iorio Alfonso , Edginton Andrea N. 
Published: December 2022

AbstractIntroductionEHL FVIII products and emicizumab provide clinicians with other prophylactic options for treating hemophilia A, however, it is unclear if emicizumab is a cost‐saving option. The objective of this study is to estimate the health and economic effects of using prophylactic EHL FVIII, SHL FVIII, and emicizumab in severe haemophilia A patients.Materials and MethodsA state‐transition Markov model evaluated the cost‐effectiveness of prophylactic SHL FVIII, EHL FVIII, and emicizumab in a cohort of 2‐year‐old male patients over a lifetime horizon in the form of a cost‐utility analysis using a Canadian provincial ministry of health payer perspective. The transition probabilities, costs, and utilities were obtained from literature and the Canadian Bleeding Disorders Registry. Probabilistic sensitivity and scenario analyses were performed to test the robustness of the model.ResultsThe base‐case analysis, over a lifetime horizon, resulted in a total cost and utilities per person for SHL FVIII, EHL FVIII, and emicizumab of $27.2 million (M), $36.7 M, and $26.2 M, respectively, and 31.30, 31.16, and 31.61 quality‐adjusted life years, respectively. Emicizumab treatment resulted in 29 and 16 less bleeds in a lifetime compared to SHL FVIII and EHL FVIII, respectively. Probabilistic sensitivity analysis showed that emicizumab was cost‐saving 100% of the time compared to SHL FVIII and EHL FVIII.ConclusionThe cost‐utility analysis showed that emicizumab is more effective and may be less costly than FVIII for Canadian haemophilia A patients, conditional on drug cost assumptions. Our model indicates that emicizumab may be a potentially favourable treatment option for minimising healthcare costs and providing higher effectiveness.
Thirty‐two years' experience of treating fulminant hepatitis in a Japanese single center
Authors: Fujiwara Keiichi , Yasui Shin , Kondo Takayuki , Nakamura Masato , Arai Makoto , Kanda Tatsuo , Yokosuka Osamu , Ohtsuka Masayuki , Abe Ryuzo , Kato Naoya 
Published: December 2022

AbstractAimThe prognosis of patients with acute liver failure has improved dramatically in the past three decades due to advances in medical critical care and use of liver transplantation (LT) in Western countries, where the etiology of acute liver failure is different from that in Japan. We analyzed patients with fulminant hepatitis (FH) and late‐onset hepatic failure (LOHF) admitted to our unit over a 32‐year period to clarify the nature of Japanese patients with FH and LOHF.MethodsA total of 137 Japanese patients with FH and LOHF between 1986 and 2017 were analyzed for etiologies, disease types, treatment protocols, and outcome.ResultsOf 137 patients, 124 were FH (53 acute type and 71 subacute type) and 13 LOHF. The major etiology was due to viral infections in 48% of patients. A total of 23.4% of patients recovered without LT, 7.3% received LT, and 69.3% died without LT. The number of patients showed rise and fall without an evident decrease during the period. Patients with autoimmune hepatitis increased after the establishment of autoimmune hepatitis criteria in 1999 (p < 0.001), and that with indeterminate cause decreased (p < 0.01). The mean age was older in the last decade than in the first decade (p = 0.036). Spontaneous and overall survival rates were not different during the period.ConclusionsThe prognosis of our patients with FH and LOHF has not improved, probably because of aging and the increasing proportion of etiologies with poor prognosis and difficult‐to‐treat patients without response to medications regardless of advancement of clinical management, including artificial liver support devices and LT.
The relation of standards and power in management and organization research: Core notions and alternative avenues
Authors: Langer Sarah 
Published: December 2022

AbstractThis paper explores how management and organization research has shed light on the relation between standards and power. The narrative literature review intersects so far unconnected categorizations from standardization and power literatures to systematically map out the broad knowledge structure of the power‐related literature on standardization. As a result, the paper details six power‐related notions of standardization. Building on the review, the paper summarizes neglected issues and suggests new avenues for future research. The analysis reveals that research widely tends toward either/or conceptions in terms of the empowering or disempowering dynamics of standardization. To descend from this dichotomous perspective in future research, the paper finally recommends exploring the dialectics of standardization in more detail: first, by analyzing standards as a reflection of existing power structures and contestations; second, by investigating standards as subject to power logics and interests; and third, by scrutinizing standardization as the dynamic interplay of powerlessness and powerfulness.
Evaluation of an international health partnership to capacity build emergency, trauma and critical care nurse education and practice in Zambia: An experience from the field
Authors: Carter Chris , Notter Joy 
Published: December 2022

AbstractAimTo evaluate an international health partnership project to capacity build emergency, trauma and critical care nurse education and practice in Zambia.BackgroundZambia continues to face a significant workforce challenge and rising burden of communicable and non‐communicable diseases, compounded by the COVID‐19 pandemic. In response to these, the Zambian Ministry of Health is investing in specialised nurses. Emergency, trauma and critical care nursing education and training were seen as one of the solutions. North–south partnerships have been identified as a force for good to capacity build and develop emerging specialities.Sources of evidenceWe use an evaluative approach, which includes desk research, a rapid literature review and documentary data analysis from published papers, government reports and project documentation. Ethics committee approval was sought and gained in both Zambia and the UK.DiscussionA critical review of the evidence identified three key themes: challenges with changing education and practice, developing Zambian faculty for sustainability and the effect of an international health partnership project on both Zambia and UK. The outcomes from this project are multifaceted; however, the main achievement has been the implementation of emergency, trauma and critical care graduate programmes by the Zambian faculty.ConclusionThis experience from the field outlines the benefits and limitations of a north–south partnership and the importance of transparency, shared ownership and collegiate decisions. It has facilitated knowledge exchange and sharing to capacity build emergency, trauma and critical care nursing.Implications for nursing practiceLessons learned may be applicable to other international nursing partnerships, these include the need for deep understanding of the context and constraints. Also, the importance of focusing on developing long‐term sustainable strategies, based on research, education and practice was noted.Implications for nursing policyThis paper outlines the importance of developing nursing education and practice to address the changing burden of disease in line with Zambian national policy, regional and international standards. Also, the value of international nursing partnerships for national and international nursing agendas was described.
The burden of non‐SARS‐CoV2 viral lower respiratory tract infections in hospitalized children in Barcelona (Spain): A long‐term, clinical, epidemiologic and economic study
Authors: Vila Jorgina , Lera Esther , Andrés Cristina , Piñana Maria , Rello‐Saltor Victoria , Tobeña‐Rué Marc , Balcells Joan , Benítez‐Díaz Zaira , Aller Marta Beatriz , Muñoz Rosario , Vázquez Ana , Rodrigo Carlos , Soler‐Palacín Pere , Antón Andrés 
Published: December 2022

AbstractBackgroundViral lower respiratory tract infections (LRTI) are the leading cause of hospitalization in children. In Catalonia (Spain), information is scarce about the burden of viral LRTIs in paediatric hospitalizations. The aim of this study is to describe epidemiological, clinical, virological and economic features of paediatric hospitalizations due to viral LRTI.MethodsFrom October 2012 to December 2020, children aged <16 years admitted to a tertiary paediatric hospital in Catalonia (Spain) with confirmed viral LRTI were included in the study. Virus seasonality, prevalence, age and sex distribution, clinical characteristics, hospital costs and bed occupancy rates were determined.ResultsA total of 3,325 children were included (57.17% male, 9.44% with comorbidities) accounting for 4056 hospitalizations (32.47% ≤ 12 months): 53.87% with wheezing/asthma, 37.85% with bronchiolitis and 8.28% with pneumonia. The most common virus was respiratory syncytial virus (RSV) (52.59%). Influenza A was associated with pneumonia (odds ratio [OR] 7.75) and caused longer hospitalizations (7 ± 31.58 days), while RSV was associated with bronchiolitis (OR 6.62) and was the most frequent reason for admission to the paediatric intensive care unit (PICU) (11.23%) and for respiratory support (78.76%). Male sex, age ≤12 months, chronic conditions and bronchiolitis significantly increased the odds of PICU admission. From October to May, viral LRTIs accounted for 12.36% of overall hospital bed days. The total hospitalization cost during the study period was €16,603,415.ConclusionsViral LRTIs are an important cause of morbidity, hospitalization and PICU admission in children. The clinical burden is associated with significant bed occupancy and health‐care costs, especially during seasonal periods.
CCN1 secreted by human adipose‐derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway
Authors: Yang Yi , Li Shiyi , Sun Xuer , Zhang Lixia , Chen Minliang , Fu Huijuan 
Published: December 2022

AbstractThe study aimed to explore the role of cellular communication network factor 1 (CCN1) an extracellular matrix protein in hADSC‐treated wound healing. Immunofluorescence and enzyme‐linked immunosorbent assays (ELISA) were used to demonstrate the secretion of CCN1 by hADSCs, isolated from human fat tissue. We investigated the role of CCN1 in wound healing by knockdown of CCN1 expression in hADSCs using CCN1 siRNA. Conditioned medium of hADSCs or hADSCs with CCN1 knocked down (hADSC‐CMCCN1↓) was collected. After treatment with plain DMEM/F12, hADSC‐CM, hADSC‐CMCCN1↓, or recombinant human CCN1 (rhCCN1), the wound healing abilities of human umbilical vascular endothelial cells (HUVECs) were assayed, and the AKT, also known as protein kinase B (PKB), signalling pathway was detected using western blotting. Next, we created full‐thickness skin wounds on the backs of the mice and different treatments were applied to the wound surface. Wound size was measured using a digital camera on days 0–10, and evaluated. H&E and immunohistochemical staining were performed, and laser Doppler perfusion imaging was used to evaluate blood perfusion. The wound model and wound‐healing assay showed that the hADSCs‐CM and rhCCN1 groups had enhanced wound healing compared to the hADSCs‐CMCCN1↓ group. Further, CCN1 and hADSCs‐CM promoted the proliferation and migration of HUVECs through the AKT signalling pathway. We concluded that CCN1 secreted by hADSCs enhances wound healing and promotes angiogenesis by activating the AKT signalling pathway. CCN1 plays a vital role in the regulation of hADSCs‐CM during wound healing.
Etude Structurale et Ultrastructurale du Rein de la Tanche, Tinca tinca L., Apres Intoxication Experimentale Par Absortion de Nitrate de Plomb
Authors: Ronckro V. , Gázquez A. , Redondo E. , Moyano M.C. , Duran E. 
Published: December 2022

SummaryStructural and ultrastructural study of tench (Tinca tinca, L.) kidney after experimental intoxication with lead nitrateA structural and ultrastructural study of tench kidney was carried out after acute intoxication with lead nitrate. 21 dosed and 8 control adult tcnchs were used.Alterations were characterized by proliferative glomerulonephritis which was more evident the longer the experiment was prolonged. Hyaline nephrosis developed, which was located especially in the first part of the proximal convoluted tubule. This alteration reached the second part of this tubule in group IV (7 days post‐intoxication), were epithelial necrosis was developed simultaneously. The intoxication triggered a degeneration of all cellular forms in the haematopoietic tissue, mainly heterophils, macrophages and eosinophils. In group IV and group V (9 days post‐intoxication) an overall necrosis of this cellular forms was observed.
Acetate Blood Serum Levels in Cows Starved for 24 Hours and in Cows Fed Different Levels of Energy and Protein before Calving
Authors: Björkman C. , Forslund K. , Jönsson G. , Olsson T. 
Published: December 2022

SummaryWhen 10 lactating cows were starved for 24 hours, the mean concentration of acetate in their blood serum decreased steadily to approximately 30 per cent of the normal level.Feeding an 80 per cent excess of energy and 100 per cent excess of protein to 13 cows for the eight weeks preceding parturition did not affect their blood acetate concentrations either two weeks before or at parturition, suggesting that, in this period, the influence of parturition is more Important than the diet for the blood acetate level. Three weeks after parturition the acetate concentrations had increased irrespective of the cows’ diets before parturition.
Histopathological Observations on Regression of Skin Lymphosarcoma in Five Cows
Authors: Ishino S. , Kadota K. , Nakagawa M. , Yoshino T. 
Published: December 2022

SummaryFive cases of bovine skin lymphosarcoma (BSL) were studied histopathologically on regression of the tumours. Neoplastic cells might be excluded by desquamation, with a hyperkeratotic epidermis in the upper dermis. In the lower dermis, lymph nodes and kidneys, neoplastic cells might become degenerated at the sites of small lymphoid cell infiltration and be dared away by macrophages. The regression of tumours in BSL might be concerned with immunological mechanisms.
Feed Refusal of Pigs Caused by Fusarium Mycotoxins in Argentina
Authors: Marpegan M. R. , Perfumo C.J. , Godoy H. M. , de Miguel M. Sala , Diaz E. , Risso M. A. 
Published: December 2022

SummaryStudies were carried out in order to determine the cause of a feed refusal condition in pigs observed in Argentina in early 1986.Mycological and chemical analysis of wheat grain and processed food, in which wheat was about 40%, showed a heavy growth of Fusarium graminearum in most of the samples. Deoxynivalenol (DON) levels varied from 1 to 20 ppm in wheat grain and from 1.7 to 8 ppm in formulated diets.Two feeding trials were performed with fattening ration containing 8 ppm of DON. Feed refusal associated with reduced food intake and weight loss was observed mainly during the first 6 to 7 days. The differences in food consumption were statistically significant when compared with findings in animals on a diet free of DON.Pathological studies of two pigs showed no gross lesions. Flydropic degeneration of hep.itocytes, degenerative changes in the renal tubular epithelium, and eosinophilic infiltrates in some lymphatic organs were the most remarkable microscopic findings. Levels of DON found in wheat and in refused commercially prepared feed correlated with feed refusal conditions previously reported in the literature and two experimental feeding trials.
Optical coherence tomography – basic optical principles
Authors: Irsch Kristina 
Published: December 2022

AbstractOptical Coherence Tomography (OCT) is an optical analogue to ultrasound imaging. The much higher speed of light compared with sound allows for finer cross‐sectional views of the retina and anterior segment. Since it is extremely difficult to directly detect the shorter “echo” times it takes light to travel from different structures at axial distances within the eye, interferometry is used. Incident light is thus split into two beams, and the beam backscattered from the ocular tissue is then compared (“interfered”) with the beam that has travelled a known time from the reference mirror. Broadband (i.e., low “coherence”) light sources are used, because they produce a wider band of wavelengths, and thereby enable greater sensitivity in comparing the travel time differences of the two beams. In time‐domain OCT, the reference mirror position is altered, so that interference patterns are generated whenever the two beams have travelled almost the same amount of time. In spectral‐domain OCT, the reference mirror position is fixed and the mixed interference patterns are separated via spectral wavelength analysis. This lecture will explain underlying concepts of OCT with a discussion of cutting‐edge technological developments.