bluuebunny/crossref_metadata_2025_split huggingface dataset:
Роль і проблематика посмертного донорства
Authors: Загрійчук М. С. , Марчук І. П. , Підопригора О. О. , Мигалега Т. С. 
Published: April 2023

Мета роботи: визначити залежність кількості експлантацій органів у ефективних посмертних донорів від віку та результатів лабораторних досліджень та дослідити частку придатних до трансплантації органів у останніх.
Матеріали і методи. В дослідження включили 14 посмертних донорів, у яких було виконано експлантацію органів у період від травня 2021 р. до грудня 2021 р. у КНП КОКЛ, з них 56,3 % становили чоловіки та 43,7 % жінки. За віком пацієнти були розділені на 2 групи: 1-ша група – молодші 50 років, 2-га група – 50 років та старші.
Результати досліджень та їх обговорення. За результатами статистичної обробки даних можна стверджувати, що групи достовірно не відрізнялись за статтю, індексом маси тіла, тривалістю перебування у ВРІТ й такими лабораторними показниками, як середній рівень креатиніну, натрію, АЛТ та АСТ, водночас спостерігалася достовірна різниця за вмістом сечовини та безпосередньо за віком, р=0,03 та р=0,000034 відповідно. Достовірної статистичної різниці за кількістю експлантацій не було.
Сучасний розвиток трансплантології в нашій країні дозволив у боротьбі за життя пацієнтів значно покращити результати. Посмертне донорство рятує життя одночасно щонайменше 4 осіб. В Україні не прописані критерії маргінального донорства, розширені критерії для донації та відсутній уніфікований протокол кондиціонування потенційного донора. Вік посмертного донора не є критичним критерієм для донації органів. Незважаючи на лабораторні показники безпеки донора, частина органів не придатна для подальшої трансплантації, в даному дослідженні це 36 % сердець, 43 % печінок та 7 % нирок. Подальші дослідження на більшій групі пацієнтів необхідні для подальшого вивчення ефективності використання донорів та післятрансплантаційних віддалених результатів.
Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice
Authors: Yang Liu , Wu Hao , Luo Congcong , Zhao Yang , Dai Rongbo , Li Zhiqing , Zhang Xu , Gong Ze , Cai Zeyu , Shen Yicong , Yu Fang , Li Wei , Zhao Hongmei , Zhang Tao , Zhu Junming , Fu Yi , Wang Jing , Kong Wei 
Published: April 2023

Background:
Thoracic aortic aneurysm and dissection (TAAD) is a highly lethal vascular disease without effective drug therapy. Whether elevated serum concentrations of uric acid are involved in TAAD development remains unclear.

Methods:
Serum uric acid levels were detected in different TAAD mouse models and patients. The urate-lowering drug allopurinol was administered in the drinking water of TAAD mice. Adenine diet–induced mice were established to investigate the role of hyperuricemia in TAAD formation and RNA-sequencing of thoracic aortas from these mice was performed.

Results:

We found serum uric acid levels were elevated in various mouse TAAD models, including mice fed a β-aminopropionitrile diet, Marfan mice with
fibrillin-1
haploinsufficiency (
Fbn1

C1041G/+

), and
ApoE

−/−

mice infused with Ang II (angiotensin II), as well as in patients with TAAD. Administration of urate-lowering drug allopurinol in the drinking water significantly alleviated TAAD formation in β-aminopropionitrile–treated mice,
Fbn1

C1041G/+

mice, and Ang II–infused
ApoE

−/−

mice. Moreover, an adenine diet was used to induce hyperuricemia in mice. Intriguingly, a 4-week adenine diet feeding directly induced TAAD formation characterized by increased maximal thoracic aortic diameters and severe elastin degradation, which were ameliorated by allopurinol. Unbiased RNA-sequencing in mouse thoracic aortas suggested that FcγR (Fc gamma receptor) was upregulated upon adenine diet, but reciprocally repressed by allopurinol. Mechanistically, hyperuricemia activated FcγR-mediated ERK1/2 (extracellular signal-regulated kinase 1/2) phosphorylation to induce macrophage inflammation and TAAD development, which was abrogated by allopurinol or FcγR deficiency.

Conclusions:
This study uncovered an important and previously unrecognized role of hyperuricemia in mediating the pathogenesis of TAAD, and uric acid–lowering drug may represent a promising therapeutic approach for TAAD.
Bone Morphogenetic Protein 10—A Novel Biomarker to Predict Adverse Outcomes in Patients With Atrial Fibrillation
Authors: Hennings Elisa , Blum Steffen , Aeschbacher Stefanie , Coslovsky Michael , Knecht Sven , Eken Ceylan , Lischer Mirko , Paladini Rebecca E. , Krisai Philipp , Reichlin Tobias , Rodondi Nicolas , Beer Jürg H. , Ammann Peter , Conte Giulio , De Perna Maria Luisa , Kobza Richard , Blum Manuel R. , Bossard Matthias , Kastner Peter , Ziegler André , Müller Christian , Bonati Leo H. , Pfister Otmar , Zuern Christine S. , Conen David , Kühne Michael , Osswald Stefan ,   the Swiss‐AF Investigators
Published: April 2023

Background
Patients with atrial fibrillation (AF) face an increased risk of death and major adverse cardiovascular events (MACE). We aimed to assess the predictive value of the novel atrial‐specific biomarker BMP10 (bone morphogenetic protein 10) for death and MACE in patients with AF in comparison with NT‐proBNP (N‐terminal prohormone of B‐type natriuretic peptide).

Methods and Results
BMP10 and NT‐proBNP were measured in patients with AF enrolled in Swiss‐AF (Swiss Atrial Fibrillation Study), a prospective multicenter cohort study. A total of 2219 patients were included (median follow‐up 4.3 years [interquartile range 3.9, 5.1], mean age 73±9 years, 73% male). In multivariable Cox proportional hazard models, the adjusted hazard ratio (aHR) associated with 1 ng/mL increase of BMP10 was 1.60 (95% CI, 1.37–1.87) for all‐cause death, and 1.54 (95% CI, 1.35–1.76) for MACE. For all‐cause death, the concordance index was 0.783 (95% CI, 0.763–0.809) for BMP10, 0.784 (95% CI, 0.765–0.810) for NT‐proBNP, and 0.789 (95% CI, 0.771–0.815) for both biomarkers combined. For MACE, the concordance index was 0.732 (95% CI, 0.715–0.754) for BMP10, 0.747 (95% CI, 0.731–0.768) for NT‐proBNP, and 0.750 (95% CI, 0.734–0.771) for both biomarkers combined. When grouping patients according to NT‐proBNP categories (<300, 300–900, >900 ng/L), higher aHRs were observed in patients with high BMP10 in the categories of low NT‐proBNP (all‐cause death aHR, 2.28 [95% CI, 1.15–4.52], MACE aHR, 1.88 [95% CI, 1.07–3.28]) and high NT‐proBNP (all‐cause death aHR, 1.61 [95% CI, 1.14–2.26], MACE aHR, 1.38 [95% CI, 1.07–1.80]).

Conclusions
BMP10 strongly predicted all‐cause death and MACE in patients with AF. BMP10 provided additional prognostic information in low‐ and high‐risk patients according to NT‐proBNP stratification.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02105844.
Knowledge gaps and conservation priorities for west African chelonians
Authors: McGovern Pearson , Luiselli Luca 
Published: April 2023

Abstract
Defining priorities is important both in research and in conservation, especially when knowledge gaps are hindering successful management. In this review, we quantify the knowledge gaps for all non-marine West African chelonians based on 21 criteria. Additionally, we combine these knowledge gaps with each species’ maximum size, range size, presence in nationally protected areas, and IUCN Red List or TFTSG provisional status to introduce a ranking of species conservation priority in the region. Our analyses revealed a divergence between which species are lacking research studies and which would benefit most from conservation actions, though Cyclanorbis elegans is the species that is both the least-known and most-in-need of conservation. Broadly, Pelomedusidae are in the greatest need of research, yet they are also collectively the least threatened. Conversely, Trionychidae and Testudinidae have received greater research attention in most cases, however, these two families represent the greatest conservation priorities amongst West African chelonians. Our analyses also enabled us to evaluate which criteria representing aspects of chelonian biology have been most overlooked by the scientific community. Priorities for future research include reproductive and long-term population studies, each of which are critical for informing conservation actions and evaluating the results of those actions.
The Building Accounts of the Fourth Century BC Temple of Apollo at Delphi
Authors: Hansen Erik 
Published: April 2023

Abstract
In this article, Hansen analyzes and discusses the construction of the fourth-century BC. Temple of Apollo at Delphi, taking into consideration the practical aspects of this difficult construction process. He includes the unique epigraphic building accounts that have been made accessible to non-philologists with Jean Bousque’s edition and French translation of the fragments published in 1989. Thereby Hansen offers a masterful revised calendar of the whole building process of the third largest temple on the Greek mainland.
The Front of a Temple and Swimming Girls by the Andokides Painter (around 520 BC)
Authors: Corso Antonio 
Published: April 2023

Abstract
This article focuses on an amphora by the Andokides Painter which dates in the late sixth-century BC, representing naked girls who swim in a basin of water with fish in front of a building endowed with a column and an architrave. Several considerations lead to the conclusion that these girls are young Athenian females in the sanctuary of Artemis Brauronia, in front of the temple built by Peisistratos. Thus, we may have the first representation of this sanctuary in our visual evidence.
Rings, Pits, Bone and Ash: Greek Altars in Context
Authors: Ekroth Gunnel 
Published: April 2023

Abstract
Greek altars have received ample attention in scholarship as to their appearance, construction, and location within a sanctuary, as well as their importance as the central feature for the rituals allowing communication with the gods. The immediate surroundings of altars have not been considered to the same degree. This paper explores the context of Greek altars and some of the features located here, for example, rings for fastening animals, stone-lined pits, and remains of previous sacrifices. Of particular interest is the use of the top of the altar for ritual purposes in relation to the space surrounding the altar. A study of the wider contexts of altars, as to their use and the material remains found here, may provide a better understanding of the complex ritual reality of the ancient Greeks.
Comparing the Two “Cold Wars” Through Gramsci, Althusser and Mao
Authors: Kadri Jude 
Published: April 2023

Abstract
There are three overlapping objectives in the article. The first objective is to present three different Marxist perspectives, while focusing on the interpretation of the base/superstructure dialectic which is the key to the understanding of Marxian political economy. The second objective is to make sense of the first and second “Cold Wars” based on the different interpretations of the base/superstructure dialectic. The last objective is to reassert the materialist essence of the base/superstructure dialectic by evoking Marx and his concepts of “Labor” and “Capital”. The three different perspectives are analyzed based on this reassertion. Through these three objectives, two deductions were made: the first deduction is that scientific Marxism requires the acknowledgement of the overdetermination of the economic base (its dominance in the last instance) in the analysis of abstractions, empirical and historical data. The “totality of the relations of production” within the economic base appears abstract in nature, but it represents the ontological category of “Labor” that defines human history since its beginning. It has a transhistorical essence. Human beings work together to produce their basic needs, according to historically specific (abstract) relations of production. The superstructure determines the specificity of the relations of production; it defines the “historical” side of the relations of production in the economic base. In the era of capitalism, “Capital” (the private appropriation of social wealth) is the dominant relation that comes to dictate the “totality of the relations of the production” within the economic base, through the superstructure. Total capital is then the real “subject” of history, and all abstractions gain purpose and practicality based on the class struggle between Labor and Capital. The second deduction relates to real history explained on the basis of the first deduction. Looking at the historical development of the class struggle against monopoly-finance capital (the centralized and concentrated capital) in the 20th century, the First Cold War never truly ended even though the global socialist ideology became weak and the ideological struggle against the imperialist superstructure watered down.
Cross-Movement Strike Actions: Works Council and Communist Groups at the Bremer Vulkan Shipyard in the 1970s
Authors: Wolf Johanna 
Published: April 2023

Abstract
Beginning in the early 1970s, various communist groups decided to become active at the Bremer Vulkan shipyard. The article shows that they did not immediately go for confrontation to older trade union structures but were willing to change the movement from within. With the support of a wildcat strike at the shipyard in 1973, the New Left raised the question of alternatives. As a result, the Social Democratic works council chairman resigned because of a lack of support from his colleagues, and in 1974 some communists were elected to the works council. I argue that there was no division into old and new but rather a diverse field of actors: a disparate group of workers with different occupational status, and political approaches; works councils and shop stewards with close ties to Bremen’s Social Democracy; and various communist groups that pursued very different policies and goals, sometimes joined forces, but basically fought each other—especially in conflicts—rather than taking joint action.
Overactive bladder and multiple sclerosis in the University Hospital of Oujda
Authors: El Moudane Anouar , Chhita Kaoutar , Jdaini Ahmed , Motaouakil Abdessamad , Mebrouk Yassine , Barki Ali 
Published: April 2023

Abstract
Background
Multiple sclerosis (MS) is the most frequent autoimmune neurological disease in the young population. Vesico-sphincter disorders are frequent in the course of the disease; it has been reported that 90% of MS patients will develop a lower urinary tract disorder within 18 years of the diagnosis.

Methods
The aim of this study is to identify the frequency, severity, diagnosis, and treatment of overactive bladder (OAB) in MS patients at the Mohammed VI hospital university in Oujda-Morocco. It is a cross-sectional study. The population was collected in neurology department of Mohammed VI hospital university in Oujda-Morocco. The population cohort consisted of patients diagnosed with multiple sclerosis, which were invited to the urology department where they underwent urinary screening and completed a form of questions regarding the frequency and severity of OAB and its influence on quality of life.

Result
In our study, the mean age of the patients was 43 years, and our sample was composed of 48% males and 52% females, and the most frequent lower urinary tract symptom was urgency (57%), followed by urinary frequency (29%) and urge incontinence (14%). The recurrent-remittent form was the most frequent (62%), followed by the primary progressive form (24%) and the secondary progressive recurrent form (14%). Among the patients, 33% presented a mild symptomatology, 48% moderate, and 19% severe. In this study, it was found that the intensity of urinary symptoms and the MS disability score were positively correlated with quality of life and disease duration.

Conclusion
The urgency was the major symptom of the lower urinary tract, and the MS disability score and the severity of OAB were associated with the quality of life of the patients. The urological evaluation of patients with multiple sclerosis should be performed routinely to identify OAB and to treat this condition appropriately.
POInTbrowse: orthology prediction and synteny exploration for paleopolyploid genomes
Authors: Siddiqui Mustafa , Conant Gavin C. 
Published: April 2023

AbstractWe describe POInTbrowse, a web portal that gives access to the orthology inferences made for polyploid genomes with POInT, the Polyploidy Orthology Inference Tool. Ancient, or paleo-, polyploidy events are widely distributed across the eukaryotic phylogeny, and the combination of duplicated and lost duplicated genes that these polyploidies produce can confound the identification of orthologous genes between genomes. POInT uses conserved synteny and phylogenetic models to infer orthologous genes between genomes with a shared polyploidy. It also gives confidence estimates for those orthology inferences. POInTbrowsegives both graphical and query-based access to these inferences from 12 different polyploidy events, allowing users to visualize genomic regions produced by polyploidies and perform batch queries for each polyploidy event, downloading genes trees and coding sequences for orthologous genes meeting user-specified criteria. POInTbrowseand the associated data are online athttps://wgd.statgen.ncsu.edu.
Timing of intubation and ICU mortality in COVID-19 patients: a retrospective analysis of 4198 critically ill patients during the first and second waves
Authors: Manrique Sara , Claverias Laura , Magret Mónica , Masclans Joan Ramón , Bodi María , Trefler Sandra , Canadell Laura , Díaz Emili , Sole-Violan Jordi , Bisbal-Andrés Elena , Natera Ruth González , Moreno Antonio Albaya , Vallverdu Montserrat , Ballesteros Juan Carlos , Socias Lorenzo , Vidal Federico Gordo , Sancho Susana , Martin-Loeches Ignacio , Rodriguez Alejandro 
Published: April 2023

Abstract
Background
The optimal time to intubate patients with SARS-CoV-2 pneumonia has not been adequately determined. While the use of non-invasive respiratory support before invasive mechanical ventilation might cause patient-self-induced lung injury and worsen the prognosis, non-invasive ventilation (NIV) is frequently used to avoid intubation of patients with acute respiratory failure (ARF). We hypothesized that delayed intubation is associated with a high risk of mortality in COVID-19 patients.

Methods
This is a secondary analysis of prospectively collected data from adult patients with ARF due to COVID-19 admitted to 73 intensive care units (ICUs) between February 2020 and March 2021.
Intubation was classified according to the timing of intubation. To assess the relationship between early versus late intubation and mortality, we excluded patients with ICU length of stay (LOS) < 7 days to avoid the immortal time bias and we did a propensity score and a cox regression analysis.

Results
We included 4,198 patients [median age, 63 (54‒71) years; 71% male; median SOFA (Sequential Organ Failure Assessment) score, 4 (3‒7); median APACHE (Acute Physiology and Chronic Health Evaluation) score, 13 (10‒18)], and median PaO2/FiO2 (arterial oxygen pressure/ inspired oxygen fraction), 131 (100‒190)]; intubation was considered very early in 2024 (48%) patients, early in 928 (22%), and late in 441 (10%). ICU mortality was 30% and median ICU stay was 14 (7‒28) days. Mortality was higher in the “late group” than in the “early group” (37 vs. 32%, p < 0.05). The implementation of an early intubation approach was found to be an independent protective risk factor for mortality (HR 0.6; 95%CI 0.5‒0.7).

Conclusions
Early intubation within the first 24 h of ICU admission in patients with COVID-19 pneumonia was found to be an independent protective risk factor of mortality.

Trial registration
The study was registered at Clinical-Trials.gov (NCT04948242) (01/07/2021).
Evaluating an app for digital medical history taking in urgent care practices: study protocol of the cluster-randomized interventional trial ‘DASI’
Authors: Noack Eva Maria , Zajontz Dagmar , Friede Tim , Antweiler Kai , Hummers Eva , Schmidt Tobias , Roddewig Lea , Schröder Dominik , Müller Frank 
Published: April 2023

Abstract
Background
In out-of-hours urgent care practices in Germany, physicians of different specialties care for a large number of patients, most of all unknown to them, resulting in a high workload and challenging diagnostic decision-making. As there is no common patient file, physicians have no information about patients’ previous conditions or received treatments. In this setting, a digital tool for medical history taking could improve the quality of medical care. This study aims to implement and evaluate a software application (app) that takes a structured symptom-oriented medical history from patients in urgent care settings.

Methods
We conduct a time-cluster-randomized trial in two out-of-hours urgent care practices in Germany for 12 consecutive months. Each week during the study defines a cluster. We will compare participants with (intervention group) and without app use (control group) prior to consultation and provision of the self-reported information for the physician. We expect the app to improve diagnostic accuracy (primary outcome), reduce physicians’ perceived diagnostic uncertainty, and increase patients’ satisfaction and the satisfaction with communication of both physician and patient (secondary outcomes).

Discussion
While similar tools have only been subject to small-scale pilot studies surveying feasibility and usability, the present study uses a rigorous study design to measure outcomes that are directly associated with the quality of delivered care.

Trial registration
The study was registered at the German Clinical Trials Register (No. DRKS00026659 registered Nov 03 2021. World Health Organization Trial Registration Data Set, https://trialsearch.who.int/Trial2.aspx? TrialID = DRKS00026659.