bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global knowledge, attitude, and practice towards COVID-19 among pregnant women: a systematic review and meta-analysis
Authors: Jahromi Abdolreza Sotoodeh , Jokar Mohammad , Sharifi Nader , Omidmokhtarloo Benyamin , Rahmanian Vahid 
Published: April 2023

AbstractBackgroundPregnant women form a specially vulnerable group due to unique changes in pregnancy, leading to a higher risk of getting a severe infection. As severe COVID-19 increases the risk of preeclampsia, preterm delivery, gestational diabetes, and low birth weight in pregnancy, there is a need to enhance pregnant women’s knowledge, attitudes, and practices to prevent these complications. This systematic review and meta-analysis aimed to determine their levels of knowledge, attitudes, and practice (KAP) regarding COVID-19 at the global level.MethodsThe systematic literature search was conducted in the English language, including Google Scholar, Scopus, PubMed/MEDLINE, Science Direct, Web of Science, EMBASE, Springer, and ProQuest, from the occurrence of the pandemic until September 2022. We used The Newcastle Ottawa scale for cross-sectional studies checklist to evaluate the risk of bias in the studies. Data were extracted by a Microsoft Excel spreadsheet and analyzed by STATA software version 14. We also employed Cochran Q statistics to assess the heterogeneity of studies and utilized Inverse variance random-effects models to estimate the pooled level of pregnant women’s KAP towards COVID-19 infection prevention.ResultsBased on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and inclusion criteria, 53 qualified studies were acquired from several countries. In total, 51 articles (17,319 participants) for knowledge, 15 articles (6,509 participants) for attitudes, and 24 articles (11,032 participants) for practice were included in this meta-analysis. The pooled good knowledge, positive attitude, and appropriate practice in pregnant women were estimated at 59%(95%CI: 52–66%), 57%(95%CI: 42–72%), and 53%(95%CI: 41–65%), respectively. According to subgroup analysis, the level of knowledge, attitude, and practice were 61%(95%CI: 49–72), 52%(95%CI: 30–74), and 50%(95%CI: 39–60), respectively, in Africa, and 58.8%(95%CI: 49.2–68.4), 60%(95%CI: 41–80) and 60% (95%CI: 41–78), respectively, in Asia.ConclusionThe Knowledge, attitude, and practice towards COVID-19 infection prevention in pregnant women were low. It is suggested that health education programs and empowerment of communities, especially pregnant women, about COVID-19 continue with better planning. For future studies, we propose to investigate the KAP of COVID-19 in pregnant women in countries of other continents and geographical regions.
Combined maternal risk factors and the Quadruple test to predict late-onset preeclampsia in pregnant Thai women
Authors: Bunyapipat Phattarika , Pruksanusak Ninlapa , Suwanrath Chitkasaem , Geater Alan 
Published: April 2023

AbstractBackgroundThis study aimed to evaluate the predictive power of a model combining maternal risk factors and the Quadruple screen test for late-onset preeclampsia (PE).MethodsAll pregnant women that received the Quadruple test for Down syndrome at 15+ 0-20+ 6weeks’ gestation were recruited. Maternal serum α-fetoprotein, β-human chorionic gonadotropin, unconjugated estriol, and inhibin A were measured as multiples of the median. A logistic regression model was used to identify predictors associated with late-onset PE with severe features. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to assess the model’s predictive ability.ResultsFifty-five of the 2,000 pregnant women had PE, and 31 of 55 women had late-onset PE. Multivariate analysis identified maternal age ≥ 35 years, inhibin A, history of previous PE, history of infertile, cardiac disease, chronic hypertension, and thyroid disease as significant risk factors. The area under the curve of the receiver operating characteristic curve was 0.78. The likelihood ratio to predict late-onset PE was 49.4 (total score > 60).ConclusionsOur model combining serum inhibin A with maternal risk factors was useful in predicting late-onset PE. Close monitoring of these patients is recommended.
Prognostic significance of lymphovascular invasion in patients with pT1b esophageal squamous cell carcinoma
Authors: Liu Linxiu , Lin Hua , Shen Guihua , Liu Yong , Qin Xiumin , Yuan Yanling , Wang Bingzhi , Xue Liyan 
Published: April 2023

Abstract
Background
Lymphovascular invasion (LVI) is a crucial predictor of lymph node metastasis (LNM). However, few studies have investigated the LVI positivity rate and its clinical significance in pT1b esophageal squamous cell carcinoma (ESCC) using immunohistochemistry and elastin staining.

Methods
We collected data from158 patients with pT1b ESCC who had undergone radical esophagectomy. All paraffin blocks of invasive carcinoma from each patient were subjected to HE staining, elastin staining + CK (AE1/AE3) immunohistochemistry (E&IHC), and CD31/D2-40 + CK (AE1/AE3) double immunohistochemistry (D-IHC). The LVI was classified into types, i.e., vascular invasion (VI) and lymphatic vessel invasion (LI), and its location, quantity, and clinical significance were explored.

Results
The positivity rates of VI by E&IHC (E-VI), VI by CD31D-IHC (CD31-VI), and LI by D2-40 D-IHC (D2-40-LI) were significantly higher than those obtained by HE staining (P < 0.001, respectively). CD31-VI and E-VI were independent adverse prognostic factors for recurrence-free survival (RFS), and they were significantly associated with poor distant metastasis-free survival and overall survival in pT1b ESCC. Intratumoral LVI was also crucial in pT1b ESCC, and L2 (the count of D2-40-LI was 5 or more) was the strongest predictor for LNM and RFS in pT1b ESCC.

Conclusion
E&IHC and D-IHC can dramatically improve the detection rate of LVI in pT1b ESCC, and the classification and grading of LVI can help to improve the prediction of LNM and prognosis.
The compared study about femoral stem malalignment with or without the special curved rasp during DAA total hip arthroplasty
Authors: Lin Bei , Lan Yiping , Lu Zhiming , Xie Shiwei , Lin Feitai , Weng Yan , Feng Eryou , Chen Jinhua 
Published: April 2023

Abstract
Objective
To investigate whether the application of a curved rasp on the femoral side is effective in reducing the incidence of stem malalignment in total hip replacement with direct anterior approach (DAA-THA), followed by the analysis of the independent risk factors affecting stem malalignment.

Methods
Retrospective analysis was carried out covering 160 patients undergoing DAA-THA from January 2019 to December 2021, with Tri-Lock (BPS, Depuy) stem applied in all 113 patients were screened according to inclusion and exclusion criteria. The data of gender, age, body mass index, preoperative diagnoses, Dorr classification, FAR ratio, pelvic morphology ratio, WOMAC scores, were analyzed to explore the independent factors influencing the malalignment of the femoral prosthesis implantation. Then data of patients were divided into group A and group B according to whether the curved rasp was taken during the operation. The chi-square test was performed to compare the incidence of femoral stem malalignment between the two groups.

Results
There revealed two independent risk factors: BMI and FAR ratio that affected femoral stem malalignment. The increased BMI was associated with a higher probability of femoral stem malalignment (P<0.05), the probability of malalignment of femoral stem in FAR ratio<1 was 1.15 times higher than that in FAR>1(OR = 1.15, 95% CI: 1.03–1.28, P<0.05). Further grouping analysis showed that the incidence of femoral stem malalignment in patients with intraoperative application of curved rasp was 27%, while in patients without curved rasp, the incidence of femoral stem malalignment increased significantly to 48.7%(P<0.05). The placement angle of prosthesis in group A was significantly better than that in group B, especially mild femoral stem malalignment (0%) and severe femoral stem malalignment (2.70%), and the difference was statistically significant (P < 0.05). There found no significant difference in age, gander, intraoperative complications and last follow-up assessment of WOMAC scores between the two groups of patients.

Conclusions
In DAA-THA, BMI and FAR ratio act as the independent risk factors for femoral stem malalignment. Intraoperative use of a curved rasp significantly reduces the incidence of malalignment of the femoral stem.
A comparative study between two methods of delivery of chemotherapeutic agent in patients with bone and soft tissue sarcoma of lower extremity
Authors: Shan Jing , Lv Sumei , Li Haihong , Wang Donglai , Zhang Xiaoyu , Liu Wei 
Published: April 2023

Abstract
Background
We aimed to compare the effects of peripherally inserted central catheters (PICC) and implantable venous access devices (TIVADs) in terms of complications and shoulder function in patients with malignant bone and soft tissue tumors of the lower extremities.

Methods
We analyzed 65 cases of TIVADs (chest wall) and 65 cases of PICC at the orthopedic department of the Fourth Hospital of Hebei Medical University between June 2019 and December 2021, which were diagnosed with malignant bone tumors or soft tissue tumors of the lower extremities (tumors had to be relatively sensitive to chemotherapy), received regular chemotherapy, with ≥ 14 cycles (42 weeks). The two groups were compared in terms of catheter indwelling time, catheter-related complications, Constant-Murley shoulder function score, and displacement of the position of the catheter end on the catheterization side.

Results
Compared to the PICC group, at six months after catheterization, the TIVADs group reported better outcomes for catheter indwelling time, catheter-related complications, and Constant-Murley score for the catheterization-side shoulder joint (p < 0.05). The TIVADs group also reported less displacement of the catheter end position after 180° abduction of the catheterization-side shoulder joint (p < 0.05).

Conclusions
Compared with PICC, TIVADs can prolong catheter indwelling time, reduce catheter-related complications, and maintain shoulder joint function, which makes it an ideal venous-access approach when providing chemotherapy to patients with malignant bone and soft tissue tumors of the lower extremities.
Ultrasonography is an effective tool for the evaluation of traumatic vertebral artery injuries distal to fourth cervical vertebra in the emergency room
Authors: Ishimoto Yuyu , Iwasaki Hiroshi , Sonekatsu Mayumi , Murata Shizumasa , Kozaki Takuhei , Hashizume Hiroshi , Tsutsui Shunji , Takami Masanari , Nagata Keiji , Hira Kazuhiro , Kato Seiya , Yamada Hiroshi 
Published: April 2023

Abstract
Background
This study aimed to determine the feasibility of ultrasonography in the assessment of cervical vertebral artery (VA) injury as an alternative to computed tomography angiography (CTA) in the emergency room.

Methods
We analyzed 50 VAs from 25 consecutive patients with cervical spine injury that had been admitted to our emergency room. Ultrasonography and CTA were performed to assess the VA in patients with cervical spine injury. We examined the sensitivity and specificity of ultrasonography compared with CTA.

Results
Among these VAs, six were occluded on CTA. The agreement between ultrasonography and CTA was 98% (49/50) with 0.92 Cohen's Kappa index. The sensitivity, specificity, and positive and negative predictive values of ultrasonography were 100%, 97.7%, 85.7%, and 100%, respectively. In one case with hypoplastic VA, the detection of flow in the VA by ultrasonography differed from detection by CTA. Meanwhile, there were two cases in which VAs entered at C5 transverse foramen rather than at C6 level. However, ultrasonography could detect the blood flow in these VAs.

Conclusions
Ultrasonography had a sensitivity of 100% compared with CTA in assessment of the VA. Ultrasonography can be used as an initial screening test for VA injury in the emergency room.
The use of intraoperative cell salvage in total hip arthroplasty with subtrochanteric shortening osteotomy for the treatment of high hip dislocation: a retrospective cohort study
Authors: Zhao Enze , Zhu Xiaoyan , Zhou Kai , Liu Zunhan , Lu Hanpeng , Chen Jiali , Zhou Zongke 
Published: April 2023

Abstract
Background
Intraoperative cell salvage (ICS) is an important component of blood management in patients undergoing orthopedic surgery. However, the role of ICS is less well defined in total hip arthroplasty (THA) with subtrochanteric shortening osteotomy (SSO) which is a common surgical technique to manage high hip dislocation. This study aimed to determine the effect of ICS during THA with SSO and to identify factors associated with the ability to salvage sufficient collection for reinfusion in patients with high hip dislocation.

Methods
We identified 178 patients who underwent THA with SSO for high hip dislocation between November 2010 and April 2021. The consecutive cohort was analyzed by logistic regression to determine the effect of ICS on postoperative allogeneic blood transfusion (ABT) and to explore the associations between patient demographics, clinical and radiographic characteristics, preoperative laboratory examination, and surgical variables with the ability to generate adequate blood salvage to reinfuse.

Results
In the consecutive cohort of 178 patients, cell salvage was reinfused in 107 patients (60.1%) and postoperative allogeneic red blood cell (RBC) transfusion within 3 days of implantation was administrated in 40 patients (22.5%). In multivariate analysis, the reinfusion of ICS (OR (95%CI) 0.17 (0.07–0.47)), center of rotation (COR) height ≥ 60 mm (OR (95%CI) 3.30 (1.21–9.01)), the length of SSO ≥ 30 mm (OR (95%CI) 2.75 (1.05–7.22)) and the use of drainage (OR (95%CI) 2.28 (1.04–5.03)) were identified as independent factors of postoperative allogeneic RBC transfusion. In addition, the following variables were identified as independent factors associated with the ability to generate sufficient blood salvage volume for reinfusion: COR height ≥ 60 mm (OR (95%CI) 3.47 (1.58–7.61)), limb-length discrepancy (LLD) ≥ 25 mm (OR (95%CI) 2.55 (1.15–5.65)) and length of SSO ≥ 30 mm (OR (95%CI) 2.75 (1.33–5.69)).

Conclusions
ICS was efficacious in reducing the exposure rate of postoperative RBC transfusion for high hip dislocation during THA with SSO. In addition, patients with greater COR height, larger LLD, and longer length of SSO were predisposed to generate sufficient collection for reinfusion in THA with SSO.
Epidemiology of musculoskeletal disorders among iranian adults: results from a non-communicable disease cohort study
Authors: Najafi Farid , Darbandi Mitra , Neya Sepideh Kazemi , Belasi Masoud Tokazebani , Izadi Neda , Pasdar Yahya , Barzegar Akbar 
Published: April 2023

Abstract
Background
Persistent pain and reduced mobility and dexterity are the typical characteristics of Musculoskeletal disorders (MSDs). We aimed to determine the prevalence of back and joint pain, back, and joint stiffness, arthritis, and osteoporosis among adults and their distribution according to sociodemographic characteristics and comorbidities.

Methods
This cross-sectional study was conducted on 9,520 participants aged 35–65 years from baseline data of the Ravansar Non-Communicable Disease (RaNCD) cohort study, in the west of Iran. MSDs were evaluated by the RaNCD cohort study physician using a standard questionnaire. Binary logistic regression was used to determine associations and reported by odds ratios (OR) and 95% confidence intervals (CI).

Results
The MSDs in women were significantly more than in men (59.06% vs. 40.94%, P < 0.001). Skeletal muscle mass (SMM) was significantly lower in subjects with MSDs, and waist circumference (WC) and visceral fat area (VFA) were higher than in the non-MSDs (P < 0.001). MSDs were significantly more common in urban men and women (OR = 1.33; 95% CI: 1.14–1.50 and OR = 1.59; 95% CI: 1.39–1.82, respectively). Obesity increased the odds of MSDs in women (OR = 1.57; 95% CI: 1.33–1.84), whereas there was no association between BMI and MSDs in men. Men with high socioeconomic status (SES) had lower odds of MSDs than men with weak SES (OR = 0.77; 95% CI: 0.64–0.92).

Conclusion
The MSDs were more prevalent among older people, women, obese people and urban dwellers. Lifestyle modification, especially weight loss may be helpful in reducing and controlling MSDs.
Posterior pelvic ring involvement detected with CT taken within a week of admission in acute fragility fractures of the pelvis (FFP) does not predict failure of conservative treatment: a retrospective cohort study
Authors: Putzeys Guy , Dekeyser Thomas , Garré Patrick , Chesser Tim , Pottel Hans 
Published: April 2023

Abstract
Background
Acute low energy pubic rami fractures in the elderly receive primarily conservative treatment. There is debate to what extent posterior ring involvement, which is detected superiorly by CT compared to X-ray, has an impact on outcome and may require modified treatment. We want to demonstrate if posterior ring involvement has an influence on different types of outcome in primarily conservatively treated acute FFP, questioning the usefulness of early CT. Additionally we analysed the early fracture pattern in cases where conservative treatment failed with need for secondary surgery.

Methods
A retrospective cohort study of 155 consecutive patients, recruited between 2009 and 2016, aged over 65 years diagnosed with an acute LE-PFr on X-ray at the emergency department of a single, level-one trauma centre and receiving an early CT. A set of outcome parameters was compared between patients with an isolated pubic rami fracture (CTia) and patients who had a combined posterior pelvic ring fracture (CTcp).

Results
There were 155 patients of whom 85.2% were female with a mean age of 83 years. 76.8% of patients living at home returned home and 15.5% moved to a nursing home. Mortality rate during hospitalisation was 6.4% and 14.8% at one year post-trauma. Secondary fracture displacement occurred in 22.6%. Secondary surgery was performed in 6 cases (3.9%). Median hospitalisation length of stay was 21 days (range 0 to 112 days). There was no significant association between the subgroups and change in residential status (p = 0.65), complications during hospitalisation (p = 0.75), mortality rate during admission (p = 0.75) and at 1 year (p = 0.88), readmission within 30 days (p = 0.46) and need for secondary surgery (p = 0.2). There was a significant increased median length of stay (p = 0.011) and rate of secondary displacement (p = 0.015) in subgroup CTcp. Secondary displacement had no impact on in-hospital complications (p = 0.7) nor mortality rate during admission (p = 0.79) or at 1 year (0.77). Early CT in patients who underwent secondary surgery showed stable B2.1 lesions in 4 of 6 cases.

Conclusions
Our data suggest that early CT in patients with conservatively treated acute LE-PFr in order to detect posterior lesions, has limited value in predicting failure of conservative treatment.
Effect of coffee on color stability and surface roughness of newly introduced single shade resin composite materials
Authors: Rohym Shaimaa , Tawfeek Hossam El Mandouh , Kamh Raghda 
Published: April 2023

AbstractBackgroundDentists started to follow the era of using single-shade resin composite restorations to avoid color shade selection. Our study was done to evaluate and compare the color stability of two single-shade resin composite materials.MethodsSixty samples were randomly allocated into two main groups (n = 30) according to the composite resin used: Group O: (Omnichroma) samples and Group V: (Venus Peral) samples. Each group was then divided into two subgroups (n = 15): group O1 and V1: samples immersed in coffee. Group O2 and V2: samples immersed in distilled water. Color changes (ΔE) and roughness values (Ra) were evaluated at baseline, first, and 14thdays of immersion. The color change was assessed using Vita Easyshade V, while surface roughness was assessed using a profilometer and Atomic Force Microscope (AFM). Data were collected and statistically analyzed using two-way variance analysis (ANOVA) and Tukey's post-hoc test (p < 0.05).ResultsGroup O1 and V1 recorded the highest ΔE00(P = 0.002, 0.0001, respectively) and Ra values (P < 0.001) with no significant difference between both materials at 14 days.ConclusionSingle shade resin composite with innovative chromatic material technology has dramatic color change and surface roughness that sacrifice esthetic success.
Prevalence and factors associated with underweight among 15–49-year-old women in Sierra Leone: a secondary data analysis of Sierra Leone demographic health survey of 2019
Authors: Ikoona Eric Nzirakaindi , Toure Mame Awa , Njenga Amon , Namulemo Lucy , Kaluya Ronald , Kamara Kassim , Oyat Freddy Wathum Drinkwater , Aloyo Judith , Kitara David Lagoro 
Published: April 2023

Abstract
Background
Women are at higher risks of being underweight than men due to biological, socio-economic, and cultural factors. Underweight women have high risks of poor obstetric outcomes. We aimed to determine the prevalence and factors associated with being underweight among women of reproductive age (15–49 years) in Sierra Leone.

Methods
We used Sierra Leone Demographic and Health Survey (2019-SLDHS) data of 7,514 women aged 15 to 49 years, excluding pregnant, post-natal, lactating, and post-menopausal women. A multistage stratified sampling approach was used to select study participants, and data was collected using validated questionnaires. A multivariable logistic regression analysis was used to determine factors associated with underweight among 15–49-year-old women in Sierra Leone. Ethical approval for the study was obtained.

Results
The prevalence of underweight was 6.7% (502/7,514). Underweight was likely among age-group of 15–24 years, AOR = 2.50,95%CI:2.39–2.60;p < 0.001 compared to 25–34 year age-group and likely among women with parity of one to four, AOR = 1.48,95%CI:1.08–2.03;p = 0.015 compared to women who never gave birth. Underweight was unlikely among women who did not listen to radios AOR = 0.67,95%CI:0.55–0.83;p < 0.001 compared to those who did; women from the north AOR = 0.73,95%CI:0.56–0.96;p = 0.026 compared to the east, and not married women AOR = 0.59,95%CI:0.47–0.76;p < 0.001 compared to married. All household wealth indices were not significantly associated with underweight.

Conclusion
The prevalence of underweight among women in the reproductive age (15–49 years) in Sierra Leone was 6.7% and it is lower compared to global and most sub-Saharan African data. Factors associated with underweight were 15–24-year age-group, and parity of one to four. Being underweight was unlikely among women who did not listen to radios, women from the north and not married. All household wealth indices were not significantly associated with underweight. Even though household wealth indices were not significantly associated with being underweight, most underweight women 68.7% (345/502) were in the poorest, poorer, and middle household wealth indices. The need to address socio-economic determinants of underweight among women (aged 15–49 years) due to household poverty is a priority in Sierra Leone.