bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new bio-inspired metaheuristic algorithm for solving optimization problems based on walruses behavior
Authors: Trojovský Pavel , Dehghani Mohammad 
Published: May 2023

AbstractThis paper introduces a new bio-inspired metaheuristic algorithm called Walrus Optimization Algorithm (WaOA), which mimics walrus behaviors in nature. The fundamental inspirations employed in WaOA design are the process of feeding, migrating, escaping, and fighting predators. The WaOA implementation steps are mathematically modeled in three phases exploration, migration, and exploitation. Sixty-eight standard benchmark functions consisting of unimodal, high-dimensional multimodal, fixed-dimensional multimodal, CEC 2015 test suite, and CEC 2017 test suite are employed to evaluate WaOA performance in optimization applications. The optimization results of unimodal functions indicate the exploitation ability of WaOA, the optimization results of multimodal functions indicate the exploration ability of WaOA, and the optimization results of CEC 2015 and CEC 2017 test suites indicate the high ability of WaOA in balancing exploration and exploitation during the search process. The performance of WaOA is compared with the results of ten well-known metaheuristic algorithms. The results of the simulations demonstrate that WaOA, due to its excellent ability to balance exploration and exploitation, and its capacity to deliver superior results for most of the benchmark functions, has exhibited a remarkably competitive and superior performance in contrast to other comparable algorithms. In addition, the use of WaOA in addressing four design engineering issues and twenty-two real-world optimization problems from the CEC 2011 test suite demonstrates the apparent effectiveness of WaOA in real-world applications. The MATLAB codes of WaOA are available in https://uk.mathworks.com/matlabcentral/profile/authors/13903104.
Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host
Authors: Loghry Hannah J. , Kwon Hyeogsun , Smith Ryan C. , Sondjaja Noelle A. , Minkler Sarah J. , Young Sophie , Wheeler Nicolas J. , Zamanian Mostafa , Bartholomay Lyric C. , Kimber Michael J. 
Published: May 2023

AbstractVector-borne, filarial nematode diseases cause significant disease burdens in humans and domestic animals worldwide. Although there is strong direct evidence of parasite-driven immunomodulation of mammalian host responses, there is less evidence of parasite immunomodulation of the vector host. We have previously reported that all life stages of Brugia malayi, a filarial nematode and causative agent of Lymphatic filariasis, secrete extracellular vesicles (EVs). Here we investigate the immunomodulatory effects of microfilariae-derived EVs on the vector host Aedes aegypti. RNA-seq analysis of an Ae. aegypti cell line treated with B. malayi microfilariae EVs showed differential expression of both mRNAs and miRNAs. AAEL002590, an Ae. aegypti gene encoding a serine protease, was shown to be downregulated when cells were treated with biologically relevant EV concentrations in vitro. Injection of adult female mosquitoes with biologically relevant concentrations of EVs validated these results in vivo, recapitulating the downregulation of AAEL002590 transcript. This gene was predicted to be involved in the mosquito phenoloxidase (PO) cascade leading to the canonical melanization response and correspondingly, both suppression of this gene using RNAi and parasite EV treatment reduced PO activity in vivo. Our data indicate that parasite-derived EVs interfere with critical immune responses in the vector host, including melanization.
Mining belt foreign body detection method based on YOLOv4_GECA model
Authors: Xiao Dong , Liu Panpan , Wang Jichun , Gu Zhengmin , Yu Hang 
Published: June 2023

AbstractIn the process of mining belt transportation, various foreign objects may appear, which will have a great impact on the crusher and belt, thus affecting production progress and causing serious safety accidents. Therefore, it is important to detect foreign objects in the early stages of intrusion in mining belt conveyor systems. To solve this problem, the YOLOv4_GECA method is proposed in this paper. Firstly, the GECA attention module is added to establish the YOLOv4_GECA foreign object detection model in the mineral belt to enhance the foreign object feature extraction capability. Secondly, based on this model, the learning rate decay of restart cosine annealing is used to improve the foreign object image detection performance of the model. Finally, we collected belt transport image information from the Pai Shan Lou gold mine site in Shenyang and established a belt foreign body detection dataset. The experimental results show that the average detection accuracy of the YOLOv4_GECA method proposed in this paper is 90.1%, the recall rate is 90.7%, and the average detection time is 30 ms, which meets the requirements for detection accuracy and real-time performance at the mine belt transportation site.
Investigating associations between physical activity, stress experience, and affective wellbeing during an examination period using experience sampling and accelerometry
Authors: Hachenberger Justin , Teuber Ziwen , Li Yu-Mei , Abkai Laura , Wild Elke , Lemola Sakari 
Published: May 2023

AbstractPrevious studies reported that physical activity could buffer the negative association of psychological stress with affective wellbeing. However, the studies that examined this relation in everyday life have assessed physical activity only by self-report but not with objective measures such as accelerometry. We therefore investigated the associations of both subjectively and objectively measured physical activity with stress experiences and affective wellbeing. A total of 90 university students participated in a 10-day experience sampling and diary study during their examination period and reported about stress experiences, physical activity, and affective states. Physical activity was additionally assessed using accelerometry in 50 of the participants. Subjectively assessed physical activity and objectively assessed light physical activity were associated with feeling less stressed in the evening. Also, light physical activity during the day was associated with a smaller increase/higher decrease in feeling stressed from morning to evening. The association of stress experience with negative affect was moderated by objective light physical activity. No interactive effects of stress intensity and physical activity on affective wellbeing were found. On stressful days, physical activity may buffer the negative association between stress and affective wellbeing. Particularly light physical activity as assessed with accelerometry seems to play an important role. It may be beneficial for students' affective wellbeing to increase or at least maintain physical activity during examination periods.
The role of tungsten oxide in Er3+-doped bismuth-germanate glasses for optical amplification in L-band
Authors: Çamiçi Hüseyin Can , Guérineau Théo , Rivera V. A. G. , Falci Rodrigo Ferreira , LaRochelle Sophie , Messaddeq Younès 
Published: May 2023

AbstractA series of novel Er3+-doped bismuth-germanate glasses containing different tungsten concentrations with a molar composition of 97.5[(75 − x)GeO2–25Bi2O3–(x)WO3]–2Sb2O3–0.5Er2O3 (x = 5, 10, 15, 20, and 25 mol%) were fabricated. Their thermal properties are measured by differential scanning calorimetry. A structural investigation by Raman spectroscopy suggested that changes occurred in the glass network by WO3 incorporation. By laser excitation at 980 nm, a strong emission from Er3+ ions at 1532 nm is observed, while the WO3 addition caused changes in the emission spectra. The emission cross-section spectra of Er3+ are calculated by both McCumber and Füchtbauer–Ladenburg theories and their comparison showed these theories yielded slightly different results, but in both cases, the calculations showed that a gain signal in L-band can be achieved when 30% of the Er3+ ions are at the excited state. This study proves that the Er3+-doped bismuth-germanate glasses are suitable for optical fiber amplifier applications operating at C- and L-band.
Features of chromosomal abnormalities in relation to consanguinity: analysis of 10,556 blastocysts from IVF/ICSI cycles with PGT-A from consanguineous and non-consanguineous couples
Authors: Melado Laura , Lawrenz Barbara , Nogueira Daniela , Raberi Araz , Patel Rachana , Bayram Asina , Elkhatib Ibrahim , Fatemi Human 
Published: May 2023

AbstractConsanguineous marriage is defined as marriage between first or second-degree cousins, with high prevalence in many cultures and societies. Descendants from consanguineous unions have an increased risk for genetic diseases. Additionally, in consanguineous couples, chromosomal disjunction during embryogenesis could also be affected, increasing the risk of chromosomal errors. Nowadays, genomic testing allows to identify new genetic syndromes and variants related to copy-number variations (CNV), including whole chromosome, segmental and micro-segmental errors. This is the first study evaluating chromosomal ploidy status on blastocysts formed from consanguineous couples during IVF/ICSI treatments with Preimplantation Genetic Testing for Aneuploidies (PGT-A), compared to non-consanguineous couples. Although consanguine couples were significantly younger, no differences were observed between groups for fertilisation rate, blastulation rate and euploidy rate, once adjusted by age. Nevertheless, the number of blastocysts biopsied on day 5 was lower for consanguine couples. Segmental errors, and aneuploidies of chromosomes 13 and 14 were the most prominent abnormalities in relation to consanguinity, together with errors in chromosome 16 and sex chromosomes when the female partner was younger than 35. Once euploid blastocysts were considered for subsequent frozen embryo transfer, pregnancy outcomes were similar in both groups. The current findings point toward the fact that in consanguine unions, not only the risk of having a child with genetic disorders is increased, but also the risk of specific chromosomal abnormalities seems to be increased. Premarital counselling and tailored reproductive treatments should be offered to these couples.
Non-target GC–MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice
Authors: Kato Mai , Yamaguchi Momoka , Ooka Akira , Takahashi Ryota , Suzuki Takuji , Onoda Keita , Yoshikawa Yuko , Tsunematsu Yuta , Sato Michio , Yoshioka Yasukiyo , Igarashi Miki , Hayakawa Sumio , Shoji Kumiko , Shoji Yutaka , Ishikawa Tomohisa , Watanabe Kenji , Miyoshi Noriyuki 
Published: June 2023

AbstractThe increased incidence of obesity in the global population has increased the risk of several chronic inflammation-related diseases, including non-alcoholic steatohepatitis (NASH)-hepatocellular carcinoma (HCC). The progression from NASH to HCC involves a virus-independent liver carcinogenic mechanism; however, we currently lack effective treatment and prevention strategies. Several reports have suggested that fecal volatile organic compounds (VOCs) are strongly associated with NASH-HCC; therefore, we explored the biomarkers involved in its pathogenesis and progression. Fecal samples collected from control and NASH-HCC model STAM mice were subjected to headspace autosampler gas chromatography-electron ionization-mass spectrometry. Non-target profiling analysis identified diacetyl (2,3-butandione) as a fecal VOC that characterizes STAM mice. Although fecal diacetyl levels were correlated with the HCC in STAM mice, diacetyl is known as a cytotoxic/tissue-damaging compound rather than genotoxic or mutagenic; therefore, we examined the effect of bioactivity associated with NASH progression. We observed that diacetyl induced several pro-inflammatory molecules, including tumor necrosis factor-α, cyclooxygenase-2, monocyte chemoattractant protein-1, and transforming growth factor-β, in mouse macrophage RAW264.7 and Kupffer KPU5 cells. Additionally, we observed that diacetyl induced α-smooth muscle actin, one of the hallmarks of fibrosis, in an ex vivo cultured hepatic section, but not in in vitro hepatic stellate TWNT-1 cells. These results suggest that diacetyl would be a potential biomarker of fecal VOC in STAM mice, and its ability to trigger the macrophage-derived inflammation and fibrosis may partly contribute to NASH-HCC carcinogenesis.
Acid-catalysed intramolecular Friedel–Crafts annulation of hetero-atom-functionalized para-quinone methides: access to O-, S- and N-based heterocycles
Authors: Sharma Sonam , Singh Gurdeep , Rekha  , Kumar Munnu , Vijaya Anand Ramasamy 
Published: June 2023

An acid catalyzed general protocol has been developed for the synthesis of xanthene, thioxanthene and indolo[1,2-a]indole derivatives from para-quinone methides via an intramolecular Friedel–Crafts reaction.
The Relationship Between Speech Accuracy and Linguistic Measures in Narrative Retells of Children With Speech Sound Disorders
Authors: Case Julie , Hallin Anna Eva 
Published: June 2023

Background:
Speech and language are interconnected systems, and language disorder often co-occurs with childhood apraxia of speech (CAS) and non-CAS speech sound disorders (SSDs). Potential trade-off effects between speech and language in connected speech in children without overt language disorder have been less explored.

Method:
Story retell narratives from 24 children (aged 5;0–6;11 [years;months]) with CAS, non-CAS SSD, and typical development were analyzed in Systematic Analysis of Language Transcripts (SALT) regarding morphosyntactic complexity (mean length of C-unit in words [MLCU]), lexical diversity (moving-average type–token ratio [MATTR]), and linguistic accuracy (any linguistic error/bound morpheme omissions) and compared to 128 age-matched children from the SALT database. Linear and mixed-effects logistic regressions were performed with speech accuracy (percent phonemes correct [PPC]) and diagnostic group as predictors of the narrative variables.

Results:
PPC predicted all narrative variables. Poorer PPC was associated with lower MLCU and MATTR as well as a higher likelihood of linguistic errors. Group differences were only observed for the error variables. Comparison to the SALT database indicated that 13 of 16 children with CAS and SSD showed a higher-than-expected proportion of linguistic errors, with a small proportion explained by individual speech errors only.

Conclusions:
The high occurrence of linguistic errors, combined with the relationship between PPC and linguistic errors in children with CAS/SSD, suggests a trade-off between speech accuracy and language output. Longitudinal studies are needed to investigate whether children with SSDs without language disorder show more language difficulties over time as linguistic demands increase.
Magnetic reconnection as an erosion mechanism for magnetic switchbacks
Authors: Suen G. H. H. , Owen C. J. , Verscharen D. , Horbury T. S. , Louarn P. , De Marco R. 
Published: June 2023

Context. Magnetic switchbacks are localised polarity reversals in the radial component of the heliospheric magnetic field. Observations from Parker Solar Probe (PSP) have shown that they are a prevalent feature of the near-Sun solar wind. However, observations of switchbacks at 1 au and beyond are less frequent, suggesting that these structures evolve and potentially erode as they propagate away from the Sun. The specific mechanisms at play have not been identified thus far.
Aims. We search for magnetic switchbacks undergoing magnetic reconnection, characterise them, and evaluate the viability of reconnection as a possible channel for their erosion.
Methods. We analysed magnetic field and plasma data from the Magnetometer and Solar Wind Analyser instruments aboard Solar Orbiter collected between 10 August and 30 August 2021. During this period, the spacecraft was 0.6–0.7 au from the Sun. Using hodographs and Walén analysis methods, we tested for rotational discontinuities (RDs) in the magnetic field and reconnection-associated outflows at the boundaries of the identified switchback structures.
Results. We identified three instances of reconnection occurring at the trailing edge of magnetic switchbacks, with properties that are consistent with existing models of reconnection in the solar wind. Based on these observations, we propose a scenario through which reconnection can erode a switchback and we estimated the timescales for these occurrences. For our events, the erosion timescales are much shorter than the expansion timescale. Thus, the complete erosion of all three observed switchbacks would occur well before they reach 1 au. Furthermore, we find that the spatial scale of these switchbacks would be considerably larger than is typically observed in the inner heliosphere if the onset of reconnection occurs close to the Sun. Our results suggest that the onset of reconnection must occur during transport in the solar wind in the cases we consider here. These results suggest that reconnection can contribute to the erosion of switchbacks and may explain the relative rarity of switchback observations at 1 au.
τ Herculid meteor shower in the night of 30/31 May 2022 and the meteoroid properties
Authors: Koten P. , Shrbený L. , Spurný P. , Borovička J. , Štork R. , Henych T. , Vojáček V. , Mánek Jan 
Published: May 2023

Context. A τ Herculid meteor outburst or even storm was predicted to occur by several models around 5 UT on 31 May 2022 as a consequence of the break-up of comet 73P/Schwassmann-Wachmann 3 in 1995. The multi-instrument and multi-station experiment was carried out within the Czech Republic to cover possible earlier activity of the shower between 21 and 1 UT on 30/31 May.
Aims. We report meteor shower activity that occurred before the main peak and provide a comparison with the dynamical simulations of the stream evolution. The physical properties of the meteoroids are also studied.
Methods. Multi-station observations using video and photographic cameras were used to calculate the atmospheric trajectories and heliocentric orbits of the meteors. Their arrival times were used to determine the shower activity profile. The physical properties of the meteoroids were evaluated using various criteria based on meteor heights. The evolution of the spectra of three meteors were studied as well.
Results. This annual but poor meteor shower was active for the whole night many hours before the predicted peak. A comparison with dynamical models shows that a mix of older material ejected after 1900 and fresh particles originating from the 1995 comet fragmentation event was observed. The radiant positions of both groups of meteors were identified and were found to agree well with the simulated radiants. Meteoroids with masses between 10 mg and 10 kg were recorded. The mass distribution index was slightly higher than 2. The study of the physical properties shows that the τ Herculid meteoroids belong to the most fragile particles observed ever, especially among higher masses of meteoroids. The exceptionally bright bolide observed during the dawn represents a challenge for the dynamical simulations as it is necessary to explain how a half-metre body was transferred to the vicinity of the Earth at the same time as millimetre-sized particles.
L’angoisse, l’objet et l’actualité des névroses actuelles
Authors: Dimitriadis Yorgos 
Published: May 2023

Dans ce texte j’avance certaines hypothèses sur la raison pour laquelle Freud revient sur la question de l’angoisse en 1926 avec son texte Inhibition symptôme, angoisse et sur le pourquoi il n’utilise plus le terme de « névroses actuelles » à partir de cette date. Les réponses à ces questions peuvent, je pense, trouver leur réponse dans la postérité, à savoir la reprise de ce texte de Freud par Lacan dans son séminaire sur l’angoisse. Par ailleurs, Lacan dans ce même séminaire va découvrir l’objet petit a qu’il a considéré comme sa seule découverte en psychanalyse. Cet objet petit a a une place logique celle qui se désigne par ce qui reste et qui, donc, échappe à des opérations de maîtrise par le « Un » de l’image qui fait unité et par les « Uns » des signifiants qui se répètent sans arriver à donner un sens final. Or, la question de ce qui fait « Un » par rapport à l’angoisse traverse les textes de Freud sur l’angoisse de 1916 à 1933. La place de cet objet, comme produit d’une séparation de l’Autre, voire de l’organe, en deçà de l’Œdipe, sert à Lacan de référence pour le passage du « Un » au « multiple », des Uns à ce qui reste. En prolongeant cette réflexion, il dégagera dans son séminaire Encore, au travers ses formules de sexuation, la logique du « pas tout » pour laquelle il n’y a plus le « Un » de l’exception. Une jouissance Autre, non phallique, y trouve sa justification.
Exokrines Pankreaskarzinom – Welche Neuerungen bringt die neue S3-Leitlinie?
Authors: Seufferlein Thomas , Kestler Angelika 
Published: May 2023

Was ist neu?
Familiäre Belastung Definition der Zielgruppe, der genetische Untersuchungen zur Abklärung eines erhöhten Pankreaskarzinomrisikos angeboten werden soll.
Präoperative Ausbreitungsdiagnostik Bei einem potenziell resektablen Pankreaskarzinom soll zusätzlich zu einer Dünnschicht-CT sowie zum Ausschluss von Lebermetastasen eine Leber-MRT oder alternativ eine FDG-PET-CT durchgeführt werden.
Chirurgische Therapie Die rein anatomischen Kriterien hinsichtlich der Resektabilität eines Pankreaskarzinoms werden um biologische Faktoren (z.B. CA19–9-Wert) und den körperlichen Allgemeinzustand (ECOG) erweitert. Es besteht ein Zusammenhang zwischen der Zahl an Pankreasresektionen an einer Institution und der Letalität, sodass erstmals eine Mindestfallzahl von ≥ 20 Pankreasresektionen für ein Zentrum empfohlen wird.
Adjuvante und neoadjuvante nicht chirurgische Therapie Aktuell wird bei gutem ECOG-Performance-Status eine adjuvante Therapie mit mFOLFIRINOX empfohlen. Eine neoadjuvante Therapie wird bei einem grenzwertig (borderline) resektablen Pankreaskarzinom empfohlen. Falls das Pankreaskarzinom als lokal fortgeschritten eingeschätzt wird, soll eine initiale Chemotherapie erfolgen. In beiden Fällen (borderline und lokal fortgeschrittenen Tumoren) wird bei stabiler Erkrankung eine chirurgische Exploration empfohlen.
Palliative Therapie des Pankreaskarzinoms Vor allem Patient*innen mit einer guten körperlichen Leistungsfähigkeit profitieren von einer Kombinationschemotherapie.
Therapiestrategien in molekularen Subgruppen Bei Nachweis einer BRCA1/2-Keimbahnmutation sollten Patient*innen eine platinhaltige Kombinationschemotherapie erhalten und können von einer Erhaltungstherapie mit einem PARP-Inhibitor profitieren. Fitten Patient*innen sollte bei Progress des Tumors eine Zweitlinientherapie angeboten werden. Eine Strahlentherapie, alleinige Radiotherapie oder Radiochemotherapie kann bei lokal fortgeschrittenem Pankreaskarzinom ohne Hinweis auf Fernmetastasen angeboten werden.