bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of graphene oxide on the mechanical and thermal strength properties of polycarbonate
Authors: Sabet Maziyar 
Published: February 2023

The mechanical and thermal properties of polycarbonate (PC) mixed with graphene oxide (GO) were investigated on an experimental basis in this study. PC composites with GO concentrations of 0.1, 0.2, 0.5, and 0.75 wt% were produced using a compression molding technique. The results showed that 10%, 26%, 55%, and 98% increased tensile strength, respectively, in comparison to PC. The thermo-mechanical test showed the tan δ value of the sample with 0.2 wt% GO reached 149.9°C, indicating a shift of 4.8° in the high-temperature region when compared to pure PC. Other mechanical tests, such as impact strength, elongation at break, and young modulus displayed the ultimate improvement for PC composites with 0.2 wt% GO content, showing that interactions with the PC and enhancements in mechanical and thermal characteristics are owing to oxygen functional groups in pure GO, mainly carboxyl portions. Therefore, the current study offers an exceptional structural characteristic, which makes the PC composite polymer qualified for high-performance composite.
Impact of COVID-19 vaccination on COVID-19 hospital admissions in England during 2021: an observational study
Authors: Cornforth Felicity , Webber Lucie , Kerr Gabriele , Dinsdale Hywell , Majeed Azeem , Greengross Peter 
Published: February 2023

Objectives To examine the impact of COVID-19 vaccination on hospital admissions in England in 2021. Design Observational study of emergency admissions for COVID-19 by vaccination status in people 16 years and over in England. Setting Hospitals in England. Participants A total of 48.1 million people registered with an English GP, aged ≥16 years with a recent NHS contact. Main outcome measures Emergency hospital admissions with a primary diagnosis of COVID-19 between 1 January and 31 December 2021. Monthly admission rates were directly standardised for age, sex, risk category and vaccination dose to estimate vaccine effectiveness (VE) over time, between vaccine doses, age groups and risk groups. Results A total of 192,047 hospital admissions were included. The unvaccinated admission rate was higher in December 2021 (6.1 admissions per 100,000 person-days; 95% CI: 5.9 to 6.3) than January 2021 (4.9; 95% CI: 4.9 to 5.0). Vaccinated admission rates were ≤1 per 100,000 from February to December. Doses 1 and 2 VE waned over time, particularly in older and clinically vulnerable groups (although this may reflect that they were vaccinated earlier). Dose 3 VE remained above 93%. Conclusions COVID-19 hospitalisations were consistently highest in the unvaccinated. Despite high case rates at the end of 2021, overall admission rates remained stable, driven by low admission rates among vaccinated people. There is population-level waning in VE, recovering after subsequent doses, potentially more marked in older and at-risk groups. The findings support JCVI (Joint Committee on Vaccination and Immunisation) guidance for an ongoing booster programme, especially in older people and higher clinical risk groups.
Polypropylene-based antibacterial and conductive composite planks: manufacturing process and property evaluations
Authors: Shih Shan-Ying , Lin Jia-Horng , Lou Ching-Wen , Jhang Jia-Ci 
Published: February 2023

Antibacterial materials are one of the important materials in our daily lives, especially in the medicine where antibacterial efficacy is indispensable. Moreover, the precise electronic instrument also requires highly electromagnetic interference shielding effectiveness (EMI SE) and as such to prevent mutual interference. Therefore, the acquisition of antibacterial property and EMI SE is essential. In this study, carbon nanotube (CNT) and triclosan (TCS) are used as conductive and antibacterial substances separately during the production of polypropylene (PP)-based antibacterial and conductive composite planks. The planks are tested for a series of physical property tests, EMI SE measurement, and antibacterial efficacy as related to the CNT content and the TCS content. The test results indicate regardless of whether it is CNT or TCS that is added, the planks exhibit good crystallinity. Furthermore, the presence of TCS contributes good antibacterial efficacy against staphylococcus aureus (S. Aureus), and the antibacterial efficacy effectuated by 0.1 wt% TCS also meets the related EU standard. In addition, the incorporation of both CNT and TCS adversely affects the EMI SE of the planks, but the resulting EMI SE remains to be between −15 dB and −20 dB.
Signature of miR-21 and MEG-2 and their correlation with TGF-β signaling in breast cancer
Authors: Desouky EM , Khaliefa AK , Hozayen WG , Shaaban SM , Hasona NA 
Published: February 2023

Breast cancer is highly prevalent and considered the main challenge to public health among females in Egypt as in other countries. MicroRNA-21 (miR-21) and MEG-2 are noncoding RNA attributed to their aberrant expression in several diseases, including breast cancer. This study aimed to assess the reliability of serum expression levels of miR-21 and MEG-2 in discriminating stages of breast cancer and scrutinize their correlations with the targeted transforming growth factor-beta (TGF-β) expression. One hundred and 30 participants whose ages ranged from 28 to 62 years were included in this study, divided into one hundred breast cancer patients and 30 healthy participants. miR-21 and TGF-β expression levels showed upregulation in patients with BC and elevated miR-21/TGF-β levels consistent with the BC stage. In addition, LncRNA (MEG-2) showed down-regulation in patients with BC. MEG-2 expression levels revealed a gradual decrease consistent with the BC stage. In addition, a negative relationship between the MEG-2 and the miR-21 and TGF-β differential expression was also noticed. This study suggested that miR-21 and MEG-2 can be used as prospective diagnostic biomarkers and emphasized the crucible role of TGF-β as therapeutic targets for BC.
Clinician by day, filmmaker by night: The development of a consumer inspired educational electroconvulsive therapy video
Authors: Ho Joanna , Wells Karen , Jacek Sarah , Francis-Taylor Rohan , Halliday Graeme 
Published: February 2023

Objective Electroconvulsive therapy (ECT) is a highly effective form of treatment used for major psychiatric disorders. However, significant stigma surrounds ECT and mental health consumers and they often report lack of knowledge prior to receiving ECT. They complain of inadequacies in information being provided by health professionals and difficulty finding reliable, balanced information that incorporates the experience of consumers who have received ECT. To address these limitations, a collaborative team of ECT consumers and health professionals created a new ECT video to provide consumers and their relatives with up-to-date, easy to understand information about ECT. The educational video includes evidence-based information from health professionals and genuine consumer perspectives. Conclusion A gap in clinical care and service provision was identified and a collaborative project was undertaken to address these limitations. In the process of creating an ECT video, many lessons were learned and a range of recommendations were implemented, including a memory rehabilitation program and new and improved access to ECT information resources.
Taking a leadership role: Gender issues and gender equity in the Royal Australian and New Zealand College of Psychiatry (RANZCP)
Authors: Golding Penny M 
Published: February 2023

Objectives This article explores the increasing number of medical women speaking out about gender inequity and sexual harassment, using the Royal Australian and New Zealand College of Psychiatry Congress 2022 as a reference. It explores the barriers for women in medical leadership known under the themes of capacity, perceived capability, and credibility and how this relates to experiences for women at work. Conclusions Sexual harms occur in the context of ongoing gender bias in our profession, even at college events. The author calls on the college to investigate and take action on sexual harms in the workplace and gender equity.
Determining the Factors Predicting the Response to Anti-HER2 Therapy in HER2-Positive Breast Cancer Patients
Authors: You Ji Young , Park Kyoung Hwa , Lee Eun Sook , Kwon Youngmee , Kim Kyoung Tae , Nam Seungyoon , Kim Dong Hee , Bae Jeoung Won 
Published: February 2023

Purpose We aimed to identify the differently expressed genes or related pathways associated with good responses to anti-HER2 therapy and to suggest a model for predicting drug response in neoadjuvant systemic therapy with trastuzumab in HER2-positive breast cancer patients. Methods This study was retrospectively analyzed from consecutively collected patient data. We recruited 64 women with breast cancer and categorized them into 3 groups: complete response (CR), partial response (PR), and drug resistance (DR). The final number of patients in the study was 20. RNA from 20 core needle biopsy paraffin-embedded tissues and 4 cultured cell lines (SKBR3 and BT474 breast cancer parent cells and cultured resistant cells) was extracted, reverse transcribed, and subjected to GeneChip array analysis. The obtained data were analyzed using Gene Ontology, Kyoto Gene and Genome Encyclopedia, Database for Annotation, Visualization and Integrated Discovery. Results In total, 6,656 genes differentially expressed between trastuzumab-susceptible and trastuzumab-resistant cell lines were identified. Among these, 3,224 were upregulated and 3,432 were downregulated. Expression changes in 34 genes in several pathways were found to be related to the response to trastuzumab-containing treatment in HER2-type breast cancer, interfering with adhesion to other cells or tissues (focal adhesion) and regulating extracellular matrix interactions and phagosome action. Thus, decreased tumor invasiveness and enhanced drug effects might be the mechanisms explaining the better drug response in the CR group. Conclusions This multigene assay-based study provides insights into breast cancer signaling and possible predictions of therapeutic response to targeted therapies such as trastuzumab.
Study on nonlinear dynamic characteristics of power six-branch herringbone gear transmission system with 3D modification
Authors: Li Zhibin , Wang Sanmin 
Published: February 2023

The power six-branch herringbone gear transmission system has the advantages of large power transmission and transmission ratio. Because of its multi-way transmission and over-constraint structure, to prevent loaded tooth interference, there are large backlashes between teeth. The system shows complex nonlinear dynamic characteristics under the influence of backlashes, which seriously affects meshing performance. The modification technology can effectively improve gear meshing performance. Hence, on the basis of optimizing meshing performance of the active pair of the six-branch herringbone gear transmission system, this article will combine 3D modification with system nonlinear vibration characteristics and propose an analysis method of the system nonlinear vibration characteristics under 3D modification to reduce vibration and noise. First, the 3D modified tooth surface equation is determined by forming grinding, the loaded transmission error (LTE) of the system's active pair is obtained by tooth contact analysis (TCA) and loaded tooth contact analysis (LTCA) technology, and the optimal modification parameters are obtained by Ant Lion Optimizer (ALO) with the minimum error amplitude as optimization objective. Then, the time-varying meshing stiffness of system under the optimal modification is calculated, and the pure torsional nonlinear dynamic model with backlashes, meshing stiffness, and static transmission error (STE) is established. Finally, the global vibration characteristics in parameter field are studied through time domain and bifurcation diagram of system. Results show that the 3D modification can eliminate edge contact of tooth and improve tooth contact performance. With the increase of input power, the root mean square (RMS) values of acceleration increase and the RMS values and jump decrease after 3D modification. With the increase of input speed, the RMS curves appear multiple resonance peaks and jumps at low input speed. After 3D modification, the RMS, jump, and resonance peak values decrease. Compared with level І, the backlashes and STEs of level II and phase difference ϛsII have great influence on system dynamic characteristics and easily make system in chaotic motion, while the 3D modification reduces their influence and makes system motion periodic.
Developing a clinical academic career pathway in a Community and Mental Health NHS Trust
Authors: Bernhardt Lizelle , Baillon Sarah , Corr Susan M , de Vries Kay 
Published: February 2023

Background: Despite growing evidence of the impact that clinical academic (CA) staff have on patient care and clinical practice, there are disproportionately low numbers of nurses, allied health professionals (AHPs) and other healthcare professionals in CA joint roles, compared to their medical colleagues. Aim: To describe the initial development of a CA career pathway for nurses, AHPs and other healthcare professionals in a Community and Mental Health NHS Trust. Methods: Kotter’s 8-Step Change Model was used to expand opportunities and research culture across an NHS Trust. Results: A variety of capacity and capability initiatives at different academic levels were created to support CA development and to complement those available externally. These opportunities were underpinned by a research and development strategy, senior leadership buy-in, manager and clinical staff support, and targeted organisation-wide communication. Conclusion: The ongoing development of innovative CA opportunities in the Trust, alongside greater support for staff interested in pursuing CA careers, has resulted in a growing number of individuals successful in developing as CAs. This has led to a growth in research culture in the organisation and a greater understanding of what CA staff can bring to patient care, the clinical service and the wider organisation.
Subpectoral proximal humeral anatomy: Guidance to decrease risk of fracture following subpectoral biceps tenodesis
Authors: Wang Hanbin , Huddleston Hailey P , Kurtzman Joey S , Gedailovich Samuel , Deegan Liam , Aibinder William R 
Published: February 2023

Background Biceps tenodesis is used for a variety of shoulder and biceps pathologies. Humeral fracture is a significant complication of this procedure. This cadaveric anatomy study sought to determine the cortical thickness of the humeral proximal shaft to identify the optimal technique to decrease unicortical drilling and reduce the risk of fracture. Methods A computed tomography (CT) of eight cadaveric humeral specimens was obtained with a metallic marker placed at the site of subpectoral tenodesis. These scans were examined to define the cortical thickness of the subpectoral region of the humerus and determine angular safe zones for reaming. Results At the standard point of a subpectoral tenodesis, a mean angle relative to the coronal plane of 29.2° medially and 21.6° laterally from the deepest portion of the bicipital groove avoided unicortical drilling with a 7 mm reamer. These values varied slightly 1 cm proximal and distal to this level. The thickest regions of cortex in the subpectoral humerus correspond to the ridges of the bicipital groove. Discussion To avoid unicortical tunnels, surgeons should limit deviation from the perpendicular approach to no more than 23° relative to the coronal plane medially and 11° relative to the coronal plane laterally.
The development of a smartphone app to enhance post-traumatic stress disorder treatment in high-risk workers
Authors: Deady Mark , Collins Daniel , Gayed Aimee , Harvey Samuel B , Bryant Richard 
Published: February 2023

Objective Post-traumatic stress disorder (PTSD) is highly prevalent in certain populations. However, evidence indicates that many individuals do not respond to treatment. Digital supports hold promise for increasing service provision and engagement but there is a lack of evidence on blended care options and still less research guiding the development of such tools. This study details the development and overarching framework used to build a smartphone app to support PTSD treatment. Methods The app was developed in line with the Integrate, Design, Assess, and Share (IDEAS) framework for the development of digital health interventions and involved clinicians (n=3), frontline worker clients (n=5) and trauma-exposed frontline workers (n=19). Integrated iterative rounds of testing were conducted via in-depth interviews, surveys, prototype testing and workshops, alongside app and content development. Results Clinicians and frontline workers both expressed a clear preference for the app to augment but not replace face-to-face therapy, with the aim of increasing between-session support, and facilitating homework completion. Content was adapted for app delivery from manualised therapy (trauma-focused cognitive behavioural therapy (CBT). Prototype versions of the app were well received, with both clinicians and clients reporting the app was easy to use, understandable, appropriate and highly recommendable. System Usability Scale (SUS) scores were on average in the excellent range (82/100). Conclusions This is one of the first studies to document the development of a blended care app designed specifically to augment clinical care for PTSD, and the first within a frontline worker population. Through a systematic framework with active end user consultation, a highly usable app was built to undergo subsequent evaluation.
Structural Changes in Human Mobility Under the Zero-COVID Strategy in China
Authors: Mu Xiaoyan , Zhang Xiaohu , Yeh Anthony Gar-On , Yu Yang , Wang Jiejing 
Published: February 2023

Over the past two years, China has wrested domestic control of the COVID-19 pandemic through non-pharmaceutical interventions. However, the extent to which the pandemic has changed people’s travel behavior in the new normal under the zero-COVID policy is not yet clear. This study investigates the profound effects of the zero-COVID strategy on human mobility in 365 Chinese cities over time. Our results suggest the following: (1) Even between city pairs with no local cases, intercity mobility decreased by an average of 16%, whereas intra-city mobility increased by 9% compared with the pre-pandemic baseline. Long-distance travel decreased substantially, while trips below 100 km increased slightly. These new trends indicate a localized pattern which is presumably caused by the wide adoption of teleworking and virtual classes, as well as concerns about the safety and availability of public transportation. (2) Containment measures caused a considerably acute decline in intercity short-distance trips but exerted a markedly lasting effect on long-distance trips. (3) Cities with lower levels of urbanization, smaller population sizes, less labor force, and lower GDP and GDP per capita experienced greater reductions in mobility, which may be due to their insufficient management capabilities. (4) The Chinese government has adopted adaptive measures to contain outbreaks. Stricter and more timely responses led to faster recoveries in the second half of 2021 compared with the first half. Inter- and intra-city mobility decreased by 41% and 26%, respectively, within the first 2 weeks of an outbreak, and it took 6-7 weeks to return to pre-outbreak levels.
Do Patients With Functional Hallux Limitus Have a Low-Lying or Bulky FHL Muscle Belly?
Authors: Sockalingam Navindravadhanam , Reymond Nils , Rybnikov Alexey , Dubois-Ferriere Victor , Assal Mathieu 
Published: February 2023

Background: Functional hallux limitus (FHLim) refers to a limitation of hallux dorsiflexion when the first metatarsal head is under load, whereas physiologic dorsiflexion is measured in the unloaded condition. Limited excursion of the flexor hallucis longus (FHL) in the retrotalar pulley has been identified as a possible cause of FHLim. A low-lying or bulky FHL muscle belly could be the cause of this limitation. However, to date, there are no published data regarding the association between clinical and anatomical findings. The purpose of this anatomical study is to correlate the presence of FHLim and objective morphologic findings through magnetic resonance imaging (MRI). Methods: Twenty-six patients (27 feet) were included in this observational study. They were divided into 2 groups, based on positive and negative Stretch Tests. In both groups, we measured on MRI the distance from the most inferior part of the FHL muscle belly and the retrotalar pulley as well as the cross-sectional area of the muscle belly 20, 30, and 40 mm proximal to the retrotalar pulley. Results: Eighteen patients had a positive Stretch Test and 9 patients had a negative Stretch Test. The mean distance between the most inferior part of the FHL muscle belly and the retrotalar pulley was 6.0 ± 6.4 mm for the positive group and 11.8 ± 9.4 mm for the negative group ( P = .039). The mean cross section of the muscle measured at 20, 30, and 40 mm from the pulley were 190 ± 90, 300 ± 112, and 395 ± 123 mm2 for the positive group and 98 ± 44, 206 ± 72, and 294 ± 61mm2 for the negative group ( P values .005, .019, and .017). Conclusion: Based on these findings, we can conclude that patients with FHLim do have a low-lying FHL muscle belly causing limited excursion in the retrotalar pulley. However, the mean volume of the muscle belly was comparable in both groups, and therefore bulkiness was not found to be a contributing factor. Level of Evidence: Level III, observational study.
Research on the technology of flame spraying aluminum coating for composite material
Authors: Guo Qiang , Zhu Junjun , Li Chao , Tang Peng , Wen Chen , Liu Lan , Wang Tianze , Hu Yeqin , Zhao Yingnan , Zhao Ming , Feng Yulong , Xu Hengyuan , Liu Hai 
Published: February 2023

Aluminum coating was prepared on composite material surface by using oxygen-acetylene flame spraying technology. The H01-103H sealants were used to seal the thermal sprayed aluminum coatings. The characteristics of the aluminum coatings with and without H01-103H sealant, including surface morphologies, phase composition, and bonding strength, were investigated by means of SEM, EDS, and mechanical testing machine. Thermal shock experiment and low temperature cooling test were also used to examine the thermal shock resistance and frost resistance of the Al coatings. Electrical conductivity and electromagnetic shielding properties were then tested according to four-probe measurement principle and GJB 5239-2004, respectively. The results showed that the bond strength was 7.36 MPa and the surface porosity was about 5.21% for Al coating without H01-103H sealant, in addition, the H01-103H sealants could fill into the pores, reducing the porosity and increasing the bond strength of the coating. Furthermore, the main component of the coating was Al, the oxygen content was only 1.43%. Flame sprayed aluminum coating, with surface electrical resistance 0.89 mΩ and 5–18 GHz electromagnetic shielding effectiveness above 35 dB, was an ideal candidate for electromagnetic shielding utilization. The Al coating remained intact, compact, no cracks, peeling, layering under 50–200°C and −30°C, which showed good thermal shock resistance and frost resistance.