bluuebunny/crossref_metadata_2025_split huggingface dataset:
lncRNA TINCR knockdown inhibits colon cancer cells via regulation of autophagy
Authors: Xu Jianhua , Zeng Wenge , Liu Tiantian , Wan Zhenda , Yang Xin , Chen Jun , Liu Fei 
Published: January 2023

AbstractThe present study aimed to evaluate the effects of long noncoding (lnc)RNA TINCR ubiquitin domain containing (TINCR) on the development of colon cancer, and the specific underlying mechanisms. The present study used adjacent healthy and cancer tissues obtained from patients with colon cancer and measured lncRNA TINCR expression using reverse transcription‐quantitative (RT‐q) PCR and in situ hybridization assays. Moreover, associations between lncRNA TINCR and clinicopathology and prognosis were also investigated. In addition, the gene and protein expression levels of lncRNA TINCR, mTOR, LC 3B, P62, and Beclin1 were measured using RT‐qPCR and western blotting assays. Cell proliferation, apoptosis, invasion, and migration were measured using MTT, Edu staining, flow cytometry, TUNEL, Transwell, and wound‐healing assays, and cell ultrastructure and LC 3B activation were measured using transmission electron microscopy and cellular immunofluorescence. Results of the present study demonstrated that lncRNA TINCR expression was significantly upregulated in colon cancer tissues, and the overall survival of the low‐expression group was significantly increased, compared with that of the high‐expression groups. In addition, the results of the present study demonstrated that lncRNA TINCR was associated with clinicopathology in patients with colon cancer. Moreover, following lncRNA TINCR knockdown using transfection with small interfering RNA‐TINCR, results of the present study demonstrated that cell proliferation was significantly reduced, while cell apoptosis was significantly increased. In addition, cell invasion and migration were significantly reduced, and autophagy was increased in HT‐29 and SW620 cell lines. However, following treatment with an mTOR agonist (an autophagy inhibitor), biological activities were significantly increased in HT‐29 and SW‐620 cell lines. Collectively, these results demonstrated that lncRNA TINCR may induce colon cancer development through the regulation of autophagy.
Vegetable proteins as encapsulating agents: Recent updates and future perspectives
Authors: Islam Fakhar , Amer Ali Yuosra , Imran Ali , Afzaal Muhammad , Zahra Syeda Mahvish , Fatima Maleeha , Saeed Farhan , Usman Ifrah , Shehzadi Umber , Mehta Shilpa , Shah Mohd Asif 
Published: January 2023

AbstractThe use of proteinaceous material is desired as it forms a protective gelation around the active core, making it safe through temperature, pH, and O2 in the stomach and intestinal environment. During the boom of functional food utilization in this era of advancement in drug delivery systems, there is a dire need to find more protein sources that could be explored for the potential of being used as encapsulation materials, especially vegetable proteins. This review covers certain examples which need to be explored to form an encapsulation coating material, including soybeans (conglycinin and glycinin), peas (vicilin and convicilin), sunflower (helianthins and albumins), legumes (glutenins and albumins), and proteins from oats, rice, and wheat. This review covers recent interventions exploring the mentioned vegetable protein encapsulation and imminent projections in the shifting paradigm from conventional process to environmentally friendly green process technologies and the sensitivity of methods used for encapsulation. Vegetable proteins are easily biodegradable and so are the procedures of spray drying and coacervation, which have been discussed to prepare the desired encapsulated functional food. Coacervation processes are yet more promising in the case of particle size formation ranging from nano to several hundred microns. The present review emphasizes the significance of using vegetable proteins as capsule material, as well as the specificity of encapsulation methods in relation to vegetable protein sensitivity and the purpose of encapsulation accompanying recent interventions.
Visually impaired people and grocery shopping in store: First evidence from brain oscillations electroencephalogram
Authors: Acconito Carlotta , Angioletti Laura , Balconi Michela 
Published: January 2023

AbstractGrocery shopping represents a challenging task for visually impaired (VI), but the neuroscientific literature on the consumption patterns of this group is still scarce. The aim of the study was to analyse the relationship between explicit consumer experience and neuropsychological measures. A group of VI and sighted explored and manipulated three different product categories inside the supermarket, while EEG, behavioral and self‐report data were collected. Electroencephalogram (EEG) findings showed a generalized delta band activity in pasta compared to frozen food and it was interpreted as higher emotional activation probably required by selecting the correct stimuli in a multisensory environment. A delta band activation was also found in frontal area in VI compared to control and it was supposed to be an index of greater cognitive control. Finally, higher delta band activity in parieto‐occipital and temporal areas were related to greater sense of disorientation. In conclusion, it was found that VI experience grocery shopping more stressfully and with greater cognitive effort (parieto‐occipital area) than people without visual disability. In general, VI use the sense of touch (temporal area) more and have more difficulties in orienting themselves internally in the store. The results could encourage the use of tactile touchpoints, braille maps, or an initial guided exploration of the supermarket, to allow the VI to memorize the internal layout of the different product categories and allow them to shop independently. Another suggestion would be to make products within the same product category more distinctive, perhaps by adding additional tactile information.
Surface and mechanical properties of polyurethane central venous catheters after repeated contact with chemotherapy excipient solutions
Authors: Khzam Afif , Saunier Johanna , Carpentier Léa , Mignot Agnès , Tortolano Lionel , Yagoubi Najet 
Published: January 2023

AbstractThis article investigates the impact of the interactions between polyurethane central venous catheters and solutions containing excipients used in cisplatin and paclitaxel formulations. Changes to the properties of catheters and the leaching of catheter additives into the infused solutions were studied while these solutions were infused cyclically for several months. Chemotherapy treatment was mimicked in vitro in compliance with hospital practices. The treatment cycle was repeated 10 times, using solutions containing only the excipients. After 10 treatment cycles, no physical or chemical degradation of the catheter was observed. Mechanical performances were stable, but surface modifications occurred, causing the surface to become more hydrophobic. A loss in polyurethane antioxidant amount was observed in part due to a leaching phenomenon.
Effect of signaled reinforcement on response variability
Authors: Reed Phil 
Published: January 2023

AbstractThree experiments examined the effect of signaling reinforcement on rats' lever pressing on contingencies that reinforced variable responding to extend the exploration of signaled reinforcement to a schedule that has previously not been examined in this respect. In Experiment 1, rats responding on a lag‐8 variability schedule with signaled reinforcement displayed greater levels of variability (U values) than rats on the same schedule lacking a reinforcement signal. In Experiment 2, rats responding on a differential reinforcement of least frequent responses schedule also displayed greater operant variability with a signal for reinforcement compared with rats without a reinforcement signal. In Experiment 3, a reinforcement signal decreased the variability of a response sequence when there was no variability requirement. These results offer empirical corroboration that operant variability responds to manipulations in the same manner as do other forms of operant response and that a reinforcement signal facilitates the emission of the required operant.
An evaluation of radiation therapy patient body mass index trends and potential impact on departmental resource planning
Authors: Laing Branagh , Caldwell Peter , Vincent Debra , Rattray Gregory 
Published: January 2023

AbstractIntroductionRadiation therapy (RT) offers a less invasive management option for bariatric cancer patients. As the proportion of Australians categorised overweight or obese approaches 70%, it is not well understood how this growth will impact RT departments. The aim of this study was to evaluate the current and potential future body mass index (BMI) of RT patients at one centre, with the purpose of identifying variables that may impact resource planning decisions.MethodsDe‐identified demographic data including gender, age, diagnosis code, activity code and BMI were obtained from MOSAIQ® oncology information system for 5548 courses of RT commenced between 2017 and 2020, and retrospectively analysed. Descriptive statistics were used to summarise the data. Simple and multiple linear regression was used to analyse for statistically significant relationships between variables.ResultsOf all patient courses, 64% were overweight or obese. Average BMI increased over time by 0.3 kg/m2 per year. Courses related to the young and elderly had a lower average BMI. Breast, brain/skull, and pelvis/prostate treatment sites had a significant association with a higher average BMI. Thorax treatment sites had a lower average BMI, but this average is increasing at the fastest rate of all treatment sites. Prone breast courses had an average BMI 5.58 kg/m2 higher than IMRT/VMAT courses.ConclusionResults demonstrate that patient BMI is increasing. Resources related to breast courses (breast board, prone board) and thorax courses (lung board) may experience increased strain in the future. Modifications to department workflow and scheduling are likely required. Further research into staffing implications is recommended.
Projection of gust wind over China under RCP8.5 scenario within CORDEX‐EA‐II project
Authors: Liu Gang , Li Tongxin , Zhu Xiaoyu , Wang Shuyu , Tang Jianping 
Published: January 2023

AbstractA wind gust parameterization scheme combined with the Weather Research and Forecasting (WRF) model used as the regional climate model (RCM) is employed to simulate and project the gust wind speed at 10‐m height above ground level for the whole China in the historical and future period 1981–2005 and 2036–2060. The gust wind speed is compared between the historical and future period to investigate its long‐term change under the background of warming climate within the CORDEX‐EA‐II project under the RCP8.5 scenario. First, the gust wind speed simulated by the gust parameterization inputted with the RCM simulations driven by the ERA‐Interim reanalysis data is compared with the ERA5 reanalysis data and their discrepancy is discussed. Then the historical/future gust wind speed is simulated/projected with the RCM simulations driven by four global climate models' results. The comparisons between the historical simulations and future projections show the gust wind speeds overall change slightly with little response to the future warming climate as the whole China is concerned, and the maximal increment and decrement of averaged annual maximal gust wind speed are, respectively, 2.25 and −2.57 m·s−1. The increases greater than 1 m·s−1 are mostly located in the eastern and southeastern coast and northwestern inland while the decreases less than −1 m·s−1 are mostly located in part of the Tibet Plateau and northwestern inland.
Genome‐wide association study of variation in cooking time among common bean (Phaseolus vulgaris L.) accessions using Diversity Arrays Technology markers
Authors: Wahome Samuel Wanjohi , Githiri Mwangi Stephen , Kinyanjui Peter Kahenya , Toili Mary Esther Muyoka , Angenon Geert 
Published: January 2023

AbstractStored grains of common bean (Phaseolus vulgaris L.) develop the hard‐to‐cook trait (HTC), which is manifested in a prolonged cooking time, thereby imposing time and energy constraints. The objective of this study was to determine variation in cooking time among common bean genotypes and to identify single nucleotide polymorphism (SNP) markers associated with cooking time.Seeds of 222 common bean accessions sourced from Kenyan institutions were multiplied in the Jomo Kenyatta University of Agriculture and Technology (JKUAT) field in 2019. The freshly harvested seeds and those stored at 35°C and 50% red haricot (RH) for 4 months for accelerated aging were soaked in distilled water for 16 h and evaluated for cooking time using the finger‐pressing method. The accessions were also genotyped to determine variation in SNP markers using Diversity Arrays Technology Sequencing (DArTseq). Genome‐wide association study (GWAS) analysis was conducted to identify SNPs significantly associated with cooking time.The study revealed significant differences (p ≤ 0.05) within and between fresh and aged bean accessions. Fresh seeds had a lower cooking time with a mean of 40.8 min and ranged from 28.1 to 72.2 min, whereas aged seeds had a higher average cooking time of 54.1 min and ranged from 32.1 to 96.3 min. GWAS identified a region in Chromosome 10 to be significantly (p ≤ 0.05) associated with the cooking time of aged seeds. Consequently, two potential candidate genes Phvul.010G038000 and Phvul.010G038100 were revealed. The characterized common bean accessions and the identified SNP markers can be utilized in breeding programs to improve the cooking quality of the common bean.
Monodromy conjecture for semi‐quasihomogeneous hypersurfaces
Authors: Blanco Guillem , Budur Nero , van der Veer Robin 
Published: January 2023

AbstractWe give a proof of the monodromy conjecture relating the poles of motivic zeta functions with roots of b‐functions for isolated quasihomogeneous hypersurfaces, and more generally for semi‐quasihomogeneous hypersurfaces. We also give a strange generalization allowing a twist by certain differential forms.
Embeddings of anisotropic Besov spaces into Sobolev spaces
Authors: Bartusel David , Führ Hartmut 
Published: January 2023

AbstractWe study the embeddings of (homogeneous and inhomogeneous) anisotropic Besov spaces associated to an expansive matrix A into Sobolev spaces, with a focus on the influence of A on the embedding behavior. For a large range of parameters, we derive sharp characterizations of embeddings.
Competitive analysis of R&D investment with R&D budget constraint and R&D uncertainty
Authors: Gao Xing , Wang Ying 
Published: January 2023

AbstractThis paper examines the cost‐reducing research and development (R&D) competition of duopolistic firms with consideration of R&D budget constraint and R&D uncertainty through constructing a game‐theoretic game. We find the R&D success probability decreases each firm's expected profit when this probability remains high because it intensifies R&D competition too much in this scenario. We show each firm suffers from an increase in R&D budget when such budget is moderate due to the intensified R&D competition as well. Furthermore, we reveal output subsidy leads to a higher expected total subsidy cost and a higher expected social welfare than R&D subsidy.
Broadband flip‐suspended‐microstrip transition for millimeter‐wave MMIC package
Authors: Zhang Bo , Jiang Wei , Zhang Yong , Wu Chengkai 
Published: January 2023

AbstractIn this letter, a novel millimeter‐wave chip packaging method based on flip‐suspended‐microstrip technology is proposed. The flip‐suspended‐microstrip contains a waveguide probe, a suspended microstrip line, input and output matching lines, and a terminal pad. The waveguide probe realizes energy coupling from the rectangular waveguide, and the terminal pad above the signal pad of chip achieves power transmission via electronic contact. Thus, the bonding wires which will bring parasitic inductance at high frequencies are avoided. To validate the proposed packaging method, back‐to‐back modules with coplanar waveguide/low noise amplifier were fabricated. The measured insertion loss of the back‐to‐back transition with a 1.75‐mm‐long coplanar waveguide is 2.6–4.2 dB over the entire D‐band, while the packaging loss of the low noise amplifier module with the back‐to‐back transition is less than 2.2 dB at 120–170 GHz, which indicate that the proposed broadband transition is feasible for millimeter‐wave chip packaging.
Approximate B1+ scaling of the SSFP steady state
Authors: Ganter Carl 
Published: January 2023

PurposeIt is shown that the steady state of rapid, TR‐periodic steady‐state free precession (SSFP) sequences at small to moderate flip angles exhibits a universal, approximate scaling law with respect to variations of . Implications for the accuracy and precision of relaxometry experiments are discussed.MethodsThe approximate scaling law is derived from and numerically tested against known analytical solutions. To assess the attainable estimator precision in a typical relaxometry experiment, we calculate the Cramér–Rao bound (CRB) and perform Monte Carlo (MC) simulations.ResultsThe approximate universal scaling holds well up to moderate flip angles. For pure steady state relaxometry, we observe a significant precision penalty for simultaneous estimation of and , whereas good estimates can be obtained without even knowing the correct actual flip angle.ConclusionSimultaneous estimation of and from a set of SSFP steady states alone is not advisable. Apart from separate measurements, the problem can be addressed by adding transient state information, but, depending on the situation, residual effects due to the scaling may still require some attention.
The Predictors of Persistent Posttracheostomy Tracheocutaneous Fistula and Successful Surgical Closure
Authors: Yosefof Eyal , Tsur Nir , Boldes Tomer , Najjar Esmat , Mizrachi Aviram , Shpitzer Thomas , Hamzany Yaniv , Bachar Gideon 
Published: January 2023

AbstractObjectivePersistent tracheocutaneous fistula is a well‐described complication of prolonged tracheostomy, with a prevalence of about 70% when decannulation is performed after more than 16 weeks. Predictors of its occurrence and outcome of treatment in adults remain unclear. The aim of the study was to describe our experience with the treatment of persistent posttracheostomy tracheocutaneous fistula in adults and to investigate factors associated with its formation and with the success of surgical closure.Study DesignRetrospective cohort.SettingTertiary medical center.MethodsPatients who underwent open‐approach tracheostomy between 2000 and 2020 were identified by database review. Data on background, need for surgical closure, and the surgical outcome was collected from the medical files and analyzed statistically between groups.ResultsOf 516 patients identified, 127 with sufficient long‐term follow‐up data were included in the study. Compared to patients whose fistula closed spontaneously (n = 85), patients who required surgical closure (n = 42) had significantly higher rates of smoking, laryngeal or thyroid malignancy, and airway obstruction as the indication for tracheostomy, on both univariate and multivariate analysis. In a comparison of patients with successful (n = 29) or failed (n = 11) surgical closure, factors significantly associated with failure were prior radiotherapy and lower preoperative albumin level, on univariate analysis.ConclusionSmoking, thyroid or laryngeal malignancy, and airway obstruction indication are risk factors for persistent posttracheostomy tracheocutaneous fistula. Patients should be closely followed after tracheostomy and referred for surgery if the fistula fails to close. Before surgery, careful evaluation of the patient's nutritional status and consideration of prior radiation treatment is mandatory.
Bridging scenario planning and backcasting: A Q‐analysis of divergent stakeholder priorities for future landscapes
Authors: Jiren Tolera Senbeto , Abson David James , Schultner Jannik , Riechers Maraja , Fischer Joern 
Published: January 2023

Abstract

Many landscapes in sub‐Saharan Africa have undergone rapid changes, often with negative social and ecological impacts. Avoiding (or reversing) such negative impacts requires proactive landscape planning. Scenario planning, a participatory approach that generates narratives of plausible landscape change trajectories in the future, has been widely used to support landscape planning and decisions. However, not least because of challenges arising from group dynamics, few examples exist where backcasting—the collective envisioning of a desirable future landscape and the identification of pathways to reach that future—has been applied in landscape planning.

In this study, building on past scenario planning work in southwestern Ethiopia, we begin to fill this empirical and methodological gap. Specifically, we used the Q‐methodology to elucidate stakeholders' divergent landscape aspirations in a case study in southwestern Ethiopia.

Our results show that many stakeholders share a similar vision of building a future landscape that supports smallholder‐based development. However, details in the envisaged pathways differ between stakeholders. Three distinct pathways were prioritized by different stakeholders: (1) Agroecological production, (2) Coffee investment and (3) Intensive food crop production. Accounting for these divergent aspirations is important when taking further steps in landscape planning.

We show how using the Q‐methodology as a subjective assessment of stakeholders' landscape priorities can facilitate the integration of backcasting within the normative process of landscape planning. Our approach thus helps navigate conflicting stakeholders' preferences and based on that, carefully plan collective action towards a shared landscape vision.

Read the free Plain Language Summary for this article on the Journal blog.
Friction and wear properties of polyacrylonitrile‐ and pitch‐based carbon fiber‐reinforced polymer matrix composites containing silicon carbide nanoparticles
Authors: Naito Kimiyoshi , Nakamura Morimasa , Matsuoka Takashi 
Published: January 2023

AbstractThis study investigated the friction and wear properties of high‐strength polyacrylonitrile (HS‐PAN)‐, high‐modulus polyacrylonitrile (HM‐PAN)‐, and high‐modulus pitch (HM‐pitch)‐based carbon fiber‐reinforced polymer matrix composites (CFRPs) with silicon carbide (SiC) nanoparticles. The fiber orientation of the CFRP specimens was set as 8‐ply unidirectional laminates, denoted as [0]8. Ball‐on‐disk (cyclic) wear testing was accompanied by laser, digital, and scanning electron microscope observations. For the HS‐PAN CFRP, the coefficient of friction and wear resistance were the highest among the HM‐PAN and HM‐pitch CFRPs and wear resistance was improved by the addition of SiC‐nanoparticles. Furthermore, there was no significant enhancement of wear resistance for the SiC‐nanoparticle‐filled and nanoparticle‐unfilled HM‐PAN CFRP. The wear resistance was improved by adding SiC‐nanoparticles for the HM‐pitch CFRP.