bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 0.1% L-Menthol Mouth Swill in Elite Male Rugby Players Has Different Effects in Forwards and Backs
Authors: Jerram Marcia L. , Baker Dane , Smith Tiaki B. , Healey Phil , Taylor Lee , Black Katherine 
Published: January 2023

Purpose: Menthol mouth swills can improve endurance performance in the heat, which is attributed to attenuations in nonthermally derived thermal sensation (TS) and perception of effort. However, research in elite team-sport athletes is absent. Therefore, this study investigated the performance and TS responses to a 0.1% menthol mouth rinse (MR) or placebo (PLA) among elite male rugby union players. Method: Twenty-seven (15 Forwards and 12 Backs) elite male Super Rugby players completed two 3-minute 15-a-side rugby-specific conditioning blocks, with MR or PLA provided at the start of training (baseline), at the start of each 3-minute block (swill 1 [S1] and swill 2 [S2]), and at the end of training (swill 3 [S3]). TS was assessed using the American Society of Heating, Refrigerating and Air-Conditioning Engineers 9-point Analog Sensation Scale after each swill and at baseline (preconditioning block). Acceptability was measured after baseline swill and S3 using a 5-question Likert scale. Physical performance was measured throughout training using global positioning system metrics. Results: MR attenuated TS from baseline to S1 (P = .003, SD = 1.01) and S2 (P = .002, SD = 1.09) in Forwards only, compared with PLA. Acceptability was higher only for Forwards in MR versus PLA at baseline (P = .003, SD = 1.3) and S3 (P = .004, SD = 0.75). MR had no effect on physical performance metrics (P > .05). Conclusion: MR attenuated the rise in TS with higher acceptability at S1 and S3 (in Forwards only) with no effect on selected physical performance metrics. Longer-duration exercise (eg, a match) in hot–humid conditions eliciting markedly increased body temperatures could theoretically allow favorable changes in TS to enhance performance—these postulations warrant experimental investigation.
Typology of how ‘harmful commodity industries’ interact with local governments in England: a critical interpretive synthesis
Authors: McKevitt Sarah , White Martin , Petticrew Mark , Summerbell Carolyn , Vasiljevic Milica , Boyland Emma , Cummins Steven , Laverty Anthony A , Junghans Cornelia , Millett Christopher , De Vocht Frank , Hrobonova Eva , Vamos Eszter P 
Published: January 2023

IntroductionIndustries that produce and market potentially harmful commodities or services (eg, tobacco, alcohol, gambling, less healthy foods and beverages) are a major influence on the drivers of behavioural risk factors for non-communicable diseases. The nature and impact of interactions between public bodies and ‘harmful commodity industries’ (HCIs) has been widely recognised and discussed at national and international levels, but to date little is known about such interactions at local or regional government levels. This study aimed to identify and characterise actual and potential interactions and proposes a typology of interactions between HCIs and English local authorities (LAs).MethodsFive electronic databases covering international literature (PubMed, EBSCO, OVID, Scopus and Web of Science) were searched up to June 2021. We also performed online searches for publicly available, web-based grey literature and documented examples of interactions in an English LA context. We conducted a critical interpretive synthesis of the published and grey literature to integrate and conceptualise the data in the context of English LAs.ResultsWe included 47 published papers to provide the frame for the typology, which was refined and contextualised for English LAs through the available grey literature. Three categories were developed, describing the medium through which interactions occur: (1) direct involvement with LAs, (2) involvement through intermediaries and (3) involvement through the local knowledge space. Within these, we grouped interactions into 10 themes defining their nature and identified illustrative examples.ConclusionOur typology identifies complex inter-relationships and characterises interactions between HCIs and LAs, with illustrative examples from English LAs. Drawn from well-established theories and frameworks in combination with contextual information on English LAs, this typology explores the LA perspective and could help local decision-makers to maximise population health while minimising negative impacts of HCIs.PROSPERO registration numberCRD42021257311
Large-scale, national, family-based epidemiological study onHelicobacter pyloriinfection in China: the time to change practice for related disease prevention
Authors: Zhou Xian-Zhu , Lyu Nong-Hua , Zhu Hui-Yun , Cai Quan-Cai , Kong Xiang-Yu , Xie Pei , Zhou Li-Ya , Ding Song-Ze , Li Zhao-Shen , Du Yi-Qi 
Published: January 2023

Background and aimsCurrent practice onHelicobacter pyloriinfection mostly focuses on individual-based care in the community, but family-basedH. pylorimanagement has recently been suggested as a better strategy for infection control. However, the family-basedH. pyloriinfection status, risk factors and transmission pattern remain to be elucidated.MethodsFrom September 2021 to December 2021, 10 735 families (31 098 individuals) were enrolled from 29 of 31 provinces in mainland China to examine family-basedH. pyloriinfection, related factors and transmission pattern. All family members were required to answer questionnaires and test forH. pyloriinfection.ResultsAmong all participants, the average individual-basedH. pyloriinfection rate was 40.66%, with 43.45% for adults and 20.55% for children and adolescents. Family-based infection rates ranged from 50.27% to 85.06% among the 29 provinces, with an average rate of 71.21%. In 28.87% (3099/10 735) of enrolled families, there were no infections; the remaining 71.13% (7636/10 735) of families had 1–7 infected members, and in 19.70% (1504/7636), all members were infected. Among 7961 enrolled couples, 33.21% had no infection, but in 22.99%, both were infected. Childhood infection was significantly associated with parental infection. Independent risk factors for household infection were infected family members (eg, five infected members: OR 2.72, 95% CI 1.86 to 4.00), living in highly infected areas (eg, northwest China: OR 1.83, 95% CI 1.57 to 2.13), and large families in a household (eg, family of three: OR 1.97, 95% CI 1.76 to 2.21). However, family members with higher education and income levels (OR 0.85, 95% CI 0.79 to 0.91), using serving spoons or chopsticks, more generations in a household (eg, three generations: OR 0.79, 95% CI 0.68 to 0.92), and who were younger (OR 0.57, 95% CI 0.46 to 0.70) had lower infection rates (p<0.05).ConclusionFamilialH. pyloriinfection rate is high in general household in China. Exposure to infected family members is likely the major source of its spread. These results provide supporting evidence for the strategic changes fromH. pyloriindividual-based treatment to family-based management, and the notion has important clinical and public health implications for infection control and related disease prevention.
Toppling television injuries in children and adolescents: a systematic review and meta-analysis
Authors: Nunez Carlos , Eslick Guy D , Elliott Elizabeth J 
Published: January 2023

ContextToppling televisions (TVs) are a source of childhood injury but meta-analysis has not assessed the likelihood of TV injuries in children.ObjectiveTo present pooled results for injuries, following a systematic review.Data sourcesMEDLINE, Scopus, Google Scholar and EMBASE databases were searched to 5 December 2022.Study selectionIncluded studies met the following criteria: (1) assessed toppling TV injuries in paediatric populations; (2) reported point estimates as an OR or enabled its calculation and (3) used a comparison group.Data extractionA standardised form was used to include information on publication year, study design, population type, country, sample size, mean age, risk factors, point estimates or data used to calculate ORs.ResultsA total of 12 803 TV injuries were identified (five studies). Head and neck injuries (OR: 2.13, 95% CI: 1.21 to 3.75) and hospital admission (OR: 2.28, 95% CI: 1.80 to 2.90) were more likely in children aged under 6 years than over 6 years. Conversely, torso injuries were less likely in younger children (OR: 0.60, 95% CI: 0.51 to 0.70). Children under 6 were two and a half times more likely to die or be admitted to an intensive care unit (ICU) as a result of toppling TVs, although this was not statistically significant. Males did not sustain more TV injuries than females.ConclusionsChildren aged under 6 years are more likely to die, sustain head injuries and require hospital treatment from toppling TVs. Strategies for injury prevention must go beyond warning labels to include community education, promotion and use of tip restraint devices, mandatory safety standards and a commitment from manufacturers to improve TV sets stability.
Spinal cord reserve in multiple sclerosis
Authors: Sastre-Garriga Jaume , Rovira Alex , García-Vidal Aran , Carbonell-Mirabent Pere , Alberich Manel , Vidal-Jordana Angela , Auger Cristina , Tintore Mar , Montalban Xavier , Pareto Deborah 
Published: January 2023

BackgroundThe spinal cord (SC) is a preferential target of multiple sclerosis (MS) damage highly relevant towards disability. Differential impact of such damage could be due to the initial amount of SC tissue, as described for the brain parenchyma (brain reserve concept). We aimed to test the existence of SC reserve by using spinal canal area (SCaA) as a proxy.MethodsBrain sagittal three-dimensional T1-weighted scans covering down to C5 level were acquired in 2930 people with MS and 43 healthy controls (HCs) in a cross-sectional, multicentre study. SC area (SCA) and SCaA were obtained with the Spinal Cord Toolbox. Demographical data and patient-derived disability scores were obtained. SC parameters were compared between groups with age-adjusted and sex-adjusted linear regression models. The main outcome of the study, the existence of an association between SCaA and Patient Determined Disease Steps, was tested with scaled linear models.Results1747 persons with MS (mean age: 46.35 years; 73.2% female) and 42 HCs (mean age: 45.56 years; 78.6% female) were analysed after exclusion of post-processing errors and application of quality criteria. SCA (60.41 mm2vs 65.02 mm2, p<0.001) was lower in people with MS compared with HC; no differences in SCaA were observed (213.24 mm2vs 212.61 mm2, p=0.125). Adjusted scaled linear models showed that a larger SCaA was significantly associated with lower scores on Patient Determined Disease Steps (beta coefficient: −0.12, p=0.0124) independently of spinal cord atrophy, brain T2 lesion volume, age and sex.ConclusionsA larger SCaA may be protective against disability in MS, possibly supporting the existence of SC reserve.
Low vitamin K status in adults with cystic fibrosis is associated with reduced body mass index, insulin secretion, and increased pseudomonal colonization
Authors: Bergeron Cindy , Potter Kathryn J. , Boudreau Valérie , Ouliass Bouchra , Bonhoure Anne , Lacombe Julie , Mailhot Marjolaine , Lavoie Annick , Ferron Mathieu , Ferland Guylaine , Rabasa-Lhoret Rémi 
Published: January 2023

Patients with cystic fibrosis (CF) are at high risk of fat-soluble vitamin deficiencies, even with supplementation. The contribution of a suboptimal vitamin K status to respiratory and endocrine pathophysiology in CF has been inadequately characterized. This is a cross-sectional study in adult CF patients (≥18 years old) from the Montreal Cystic Fibrosis Cohort. Vitamin K1 (VK1) was measured with high-performance liquid chromatography, using fasted serum samples collected during an oral glucose tolerance test (OGTT: 2 h with plasma glucose and insulin every 30 min) ( n = 168). Patients were categorized according to VK1 status (suboptimal defined as <0.30 nmol/L). Suboptimal VK1 levels were observed in 66% of patients. Patients with a suboptimal VK1 status have a higher risk of colonization with Pseudomonas aeruginosa ( p = 0.001), have lower body mass index (BMI) ( p = 0.003), and were more likely to have exocrine pancreatic insufficiency ( p = 0.002). Using an established threshold for VK1, we did show significantly reduced OGTT-derived measures of insulin secretion in patients with a VK1 status below 0.30 nmol/L (first- and second-phase area under the curve (AUC)INS/GLU ( p = 0.002 and p = 0.006), AUCINS ( p = 0.012) and AUCINS/GLU ( p = 0.004)). Subclinical vitamin K deficiency is more common than other fat-soluble vitamin deficiencies in patients with CF. We demonstrate an association between a suboptimal VK1 status and measures of insulin secretion. We highlight the potential associations of mild vitamin K deficiency with pseudomonal colonization and lower BMI, although these need to be validated in prospective studies.
Thermal convection in a higher-gradient Navier–Stokes fluid
Authors: Straughan Brian 
Published: January 2023

AbstractWe discuss models for flow in a class of generalized Navier–Stokes equations. The work concentrates on producing models for thermal convection, analysing these in detail, and deriving critical Rayleigh and wave numbers for the onset of convective fluid motion. In addition to linear instability theory we present a careful analysis of fully nonlinear stability theory. The theories analysed all possess a bi-Laplacian term in addition to the normal spatial derivative term. The theories discussed are Stokes couple stress theory, dipolar fluid theory, Green–Naghdi theory, Fried–Gurtin–Musesti theory, and a second theory of Fried and Gurtin. We show that the Stokes couple stress theory and the Fried–Gurtin–Musesti theory involve the same partial differential equations while those of Green–Naghdi and dipolar theory are similar. However, we concentrate on boundary conditions which are crucial to understand all five theories and their differences.
Explaining Recommendations through Conversations: Dialog Model and the Effects of Interface Type and Degree of Interactivity
Authors: Hernandez-Bocanegra Diana C. , Ziegler Jürgen 
Published: January 2023

Explaining system-generated recommendations based on user reviews can foster users’ understanding and assessment of the recommended items and the recommender system (RS) as a whole. While up to now explanations have mostly been static, shown in a single presentation unit, some interactive explanatory approaches have emerged in explainable artificial intelligence (XAI), making it easier for users to examine system decisions and to explore arguments according to their information needs. However, little is known about how interactive interfaces should be conceptualized and designed to meet the explanatory aims of transparency, effectiveness, and trust in RS. Thus, we investigate the potential of interactive, conversational explanations in review-based RS and propose an explanation approach inspired by dialog models and formal argument structures. In particular, we investigate users’ perception of two different interface types for presenting explanations, a graphical user interface (GUI)-based dialog consisting of a sequence of explanatory steps, and a chatbot-like natural-language interface.
Since providing explanations by means of natural language conversation is a novel approach, there is a lack of understanding how users would formulate their questions with a corresponding lack of datasets. We thus propose an intent model for explanatory queries and describe the development of ConvEx-DS, a dataset containing intent annotations of 1,806 user questions in the domain of hotels, that can be used to to train intent detection methods as part of the development of conversational agents for explainable RS. We validate the model by measuring user-perceived helpfulness of answers given based on the implemented intent detection. Finally, we report on a user study investigating users’ evaluation of the two types of interactive explanations proposed (GUI and chatbot), and to test the effect of varying degrees of interactivity that result in greater or lesser access to explanatory information. By using Structural Equation Modeling, we reveal details on the relationships between the perceived quality of an explanation and the explanatory objectives of transparency, trust, and effectiveness. Our results show that providing interactive options for scrutinizing explanatory arguments has a significant positive influence on the evaluation by users (compared to low interactive alternatives). Results also suggest that user characteristics such as decision-making style may have a significant influence on the evaluation of different types of interactive explanation interfaces.
ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm
Authors: Cai Dunpeng , Sun Chenming , Murashita Takashi , Que Xingyi , Chen Shi-You 
Published: January 2023

Background:
Macrophage activation plays a critical role in abdominal aortic aneurysm (AAA) development. However, molecular mechanisms controlling macrophage activation and vascular inflammation in AAA remain largely unknown. The objective of the study was to identify novel mechanisms underlying adenosine deaminase acting on RNA (ADAR1) function in macrophage activation and AAA formation.

Methods:
Aortic transplantation was conducted to determine the importance of nonvascular ADAR1 in AAA development/dissection. Ang II (Angiotensin II) infusion of ApoE−/− mouse model combined with macrophage-specific knockout of ADAR1 was used to study ADAR1 macrophage-specific role in AAA formation/dissection. The relevance of macrophage ADAR1 to human AAA was examined using human aneurysm specimens. Moreover, a novel humanized AAA model was established to test the role of human macrophages in aneurysm formation in human arteries.

Results:
Allograft transplantation of wild-type abdominal aortas to ADAR1+/− recipient mice significantly attenuated AAA formation, suggesting that nonvascular ADAR1 is essential for AAA development. ADAR1 deficiency in hematopoietic cells decreased the prevalence and severity of AAA while inhibited macrophage infiltration and aorta wall inflammation. ADAR1 deletion blocked the classic macrophage activation, diminished NF-κB (nuclear factor kappa B) signaling, and enhanced the expression of a number of anti-inflammatory microRNAs. Mechanistically, ADAR1 interacted with Drosha to promote its degradation, which attenuated Drosha-DGCR8 (DiGeorge syndrome critical region 8) interaction, and consequently inhibited pri- to pre-microRNA processing of microRNAs targeting IKKβ, resulting in an increased IKKβ (inhibitor of nuclear factor kappa-B) expression and enhanced NF-κB signaling. Significantly, ADAR1 was induced in macrophages and interacted with Drosha in human AAA lesions. Reconstitution of ADAR1-deficient, but not the wild type, human monocytes to immunodeficient mice blocked the aneurysm formation in transplanted human arteries.

Conclusions:
Macrophage ADAR1 promotes aneurysm formation in both mouse and human arteries through a novel mechanism, that is, Drosha protein degradation, which inhibits the processing of microRNAs targeting NF-kB signaling and thus elicits macrophage-mediated vascular inflammation in AAA.
The Observation-Based Index to Investigate the Role of the Lee Vortex in Enhancing Air Pollution over Northwestern Taiwan
Authors: Hsu Tzu-Han , Chen Wei-Ting , Wu Chien-Ming , Hsieh Min-Ken 
Published: January 2023

Abstract
This study quantifies the potential effect of the lee vortex on the fine particulate matter (PM2.5) pollution deterioration under the complex topography in Taiwan using observational data. We select the lee-vortex days that favor the development of the lee vortices in northwestern Taiwan under the southeasterly synoptic winds. We then define the enhancement index that discerns the areas with the high occurrence frequencies of the PM2.5 enhancement under the flow regime relative to the seasonal background concentrations. Under the lee-vortex days, the center of western Taiwan exhibits enhancement indices higher than 0.65. In addition, during the consecutive lee-vortex days, the index characterizes a northward shift in the PM2.5-enhanced areas under the subtle transition of the background wind directions. The areas with indices higher than 0.65 expand on the second day in northwestern Taiwan; the number of stations exhibiting indices higher than 0.8 increases by threefold from the first to the second day. The idealized numerical simulations using the Taiwan vector vorticity equation cloud-resolving model (TaiwanVVM) explicitly resolve the structures of leeside circulations and the associated pollutant transport, and their evolutions are highly sensitive to the background winds.

Significance Statement
Our study investigates the challenging question of local circulation patterns affected by mountain orography and the associated pollutant transport. We analyzed long-term balloon sounding and ground station observations to select the weather regime favoring the formation of lee vortices on Taiwan island. We then quantified the areas with a frequent enhancement of particulate pollutants. The long-term trend of the lee-vortex days exhibited a significant increase in the past decades. The pollution enhancement areas are highly consistent with the regions dominated by leeside local circulation. Together with the idealized high-resolution simulations, we identified that the detailed evolution of the lee vortices is highly sensitive to the subtle changes in background wind direction and hence the redistribution of local pollution.
Trends, challenges, and priorities for shared decision making in mental health: The first umbrella review
Authors: Chmielowska Marta , Zisman-Ilani Yaara , Saunders Rob , Pilling Stephen 
Published: January 2023

Background: Shared decision making (SDM) is a health communication model promoting patient-centered care that has not been routinely utilized in mental health. Inconsistent definitions, models, measurement tools, and lack of sufficient evidence for the effectiveness of SDM interventions are potential contributors to the limited use of SDM in mental health. Aims: (1) Provide the first systematic analysis of global development trends and challenges of SDM research; (2) clarify the meaning, role, and measurement of SDM in mental health; (3) create a theoretical framework for key effective SDM components to guide future development and implementation of SDM interventions. Methods: A comprehensive search strategy was conducted in CINAHL, PubMed, Scopus, MEDLINE, EMBASE, Cochrane Library, Web of Science, Scopus, and PsycInfo. Included reviews focused on SDM interventions for prevention and/or treatment of mental illness in adults. A narrative synthesis was performed to capture the range of interventions, populations, measurement tools, comparisons, and outcomes. Results: 10 systematic reviews of SDM in mental health were included with 100 nested studies spanning from 2006 to 2020. All reviews focused on dyadic and psychopharmacological decision-making. Primary outcomes of SDM in mental health interventions include treatment satisfaction, medication adherence, symptom severity, quality of life, and hospital readmissions. Participant-related factors unique to SDM in mental health, such as stigma and mental capacity, were not reported. Conclusions: The current landscape of SDM in mental health is overwhelmingly disconnected from the needs and experiences of potential end-users; clients, clinicians, and family members. Most SDM interventions and tools were adapted from physical health and are mainly geared to psychopharmacological decision-making. The SDM in Mental Health Framework (SDM-MH), developed here, expands the scope of decisions to non-psychopharmacological discussions, diversifies the pool of SDM participants and settings, and offers potential primary target outcomes of SDM in mental health to reduce heterogeneity across studies.