bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute pancreatitis in pregnancy: A propensity score matching analysis and dynamic nomogram for risk assessment
Authors: Tang Xiaowei , Chen Yuan , Huang Shu , Jiang Jiao , Luo Bei , Ren Wensen , Zhou Xueqin , Shi Xiaomin , Zhang Wei , Shi Lei , Zhong Xiaolin , Lü Muhan 
Published: August 2023

Abstract

BACKGROUND: Acute pancreatitis is easily confused with abdominal pain symptoms, and it could lead to serious complications for pregnant women and fetus, the mortality was as high as 3.3% and 11.6%-18.7%, respectively. However, there is still lack of sensitive laboratory markers for early diagnosis of APIP and authoritative guidelines to guide treatment.
ONJECTIVE: The purpose of this study was to explore the risk factors of acute pancreatitis in pregnancy, establish and evaluate the dynamic prediction model of risk factors in acute pancreatitis in pregnancy patients.
STUDY DESIGN: Clinical data of APIP patients and non-pregnant acute pancreases patients who underwent regular antenatal check-ups during the same period were collected. The data set after propensity matching was randomly divided into training set and verification set at a ratio of 7:3. The model was constructed by using Logistic regression, least absolute shrinkage and selection operator regression, R language and other methods. The training set model was used to construct the diagnostic nomogram model and the validation set was used to validate the model. Finally, the accuracy and clinical practicability of the model were evaluated.
RESULTS: A total of 111 APIP were included. In all APIP patients, biliary pancreatitis was the most important reason (62.1%). The levels of serum amylase, creatinine, albumin, triglyceride, high density lipoprotein cholesteroland apolipoprotein A1 were significantly different between the two groups. The propensity matching method was used to match pregnant pancreatitis patients and pregnant non-pancreatic patients 1:1 according to age and gestational age, and the matching tolerance was 0.02. The multivariate logistic regression analysis of training set showed that diabetes, triglyceride, Body Mass Index, white blood cell, C-reactive protein were identified and entered the dynamic nomogram. The area under the ROC curve of the training set was 0.942 and in validation set was 0.842. The calibration curve showed good predictive in training set, the calibration performance in the validation set was acceptable. The calibration curve showed the consistency between the nomogram model and the actual probability.
CONCLUSION: The dynamic nomogram model we constructed to predict the risk factors of acute pancreatitis in pregnancy has high accuracy, discrimination and clinical practicability.
The Impact of Time to Surgery on Prognosis of Stage I-III Colon Cancer Patients: A Retrospective Cohort Study
Authors: Liu Mengmei , Liu Lizhu , Li Yanli , You Ruimin , Yan Guanghong , Li Min , Chen Ping , Ma Qingyan , You Dingyun , Li Zhenhui , Pu Hongjiang 
Published: August 2023

Abstract
Background: The timing of surgery has been shown to affect the outcome of many forms of cancer, but the optimal timing of surgery for patients with colon cancer remains unclear. The primary aim of this study was to examine the correlation between the time to surgery (TTS) and overall survival rates in stage I-III colon cancer patients, thereby determining the optimal surgical intervention timing.
Methods: A retrospective cohort study was executed at a comprehensive oncology center, scrutinizing a consecutive series of patients who underwent curative resection for stage I-III CC between September 2008 and September 2017. The time to surgery(TTS) was defined as the interval between diagnosis and surgical intervention. The study primarily concentrated on overall survival rates contingent on distinct TTS thresholds (1 to 2 weeks, 3 to 4 weeks, and beyond 4 weeks). Both univariate and multivariate analyses were utilized to evaluate the prognostic implications of TTS. Furthermore, a subgroup analysis was undertaken employing the TTS thresholds of 1 to 2 weeks.
Results: The study incorporated 1188 patients (700 (58.90%) females and 488 (41.10%) males) with a mean age of 58.5 ± 11.88 years. The median (IQR) time to surgery was 10 (7 - 15) days. Patients with a TTS of 1 to 2 weeks had a 5-year overall survival rate of 82% (n = 866), compared to 90% (n = 282) for those with a TTS of 3 to 4 weeks (p = 0.003). Multivariable Cox-regression analyses indicated that a TTS exceeding 4 weeks bore no association with overall survival, whereas a TTS of 1 to 2 weeks emerged as a significant independent risk factor for decreased overall survival in the entire cohort (hazard ratio (HR), 1.93; 95% confidence interval: 1.28 - 2.62).
Conclusions: The optimal timing for definitive resection in colon cancer is situated between 3 and 4 weeks subsequent to the initial diagnosis. It is of paramount importance that efforts are made to ensure patients undergo definitive surgery within this 3 to 4 week window after the initial diagnosis to optimize overall survival rates.
The effect of laboratory synthesized and modified layered double hydroxides on recycled and neat high density polyethylene matrix properties using stearic acid as an interface modifier
Authors: DERRADJ Mourad , Zoukrami Fouzia , GUERBAA Hadjira , BENCHAOUI Abdelmounaim 
Published: August 2023

Abstract
In this research, the effect of layered double hydroxides (LDHs) as nanofillers on recycled and neat high density polyethylene (HDPE) properties was investigated. The synthesis of unmodified and modified LDHs was achieved via one-pot hydrothermal co-precipitation method at a constant pH. The nanofillers were organically modified by using sodium dodecyl sulphate (SDS) as surfactant and stearic acid (SA) as an interface modifier in order to overcome the incompatibility problems with HDPE Matrix. The nanocomposites were prepared by melt blending and compression molding with 3 and 5 wt% filler loading rate. Thermal, structural, and morphological tests were conducted to analyze the performance of the LDHs and the compatibilizing agent on the dispersion, and on the properties of the studied composites. Results revealed that 3 wt% of unmodified LDHs filler reinforced all physical and mechanical properties of the obtained nanocomposites based on recycled and neat HDPE matrix. When the weight of LDHs was increased to 5 wt%, morphological observations showed that SA has prevented the aggregation of LDHs particles and improved their dispersion into the recycled HDPE matrix. The physical and mechanical properties of the composite materials were enhanced dramatically with the addition of stearic acid as interface modifier into the recycled polymeric matrix compared to SDS intercalating which improved only the izod impact strength. The formulations of r-HDPE/3%LDH and r-HDPE/5%LDH-1%SA were found to be the ideal combinations which could provide novel mechanical applications to meet industrial requirements at higher scale.
RAMP1 as a Novel Prognostic Biomarker in Pan-cancer and Osteosarcoma
Authors: Xie Long , Xiao Weiwei , Fang Hangqi , Liu Guoqiang 
Published: August 2023

Abstract
Receptor activity modifying protein 1 (RAMP1) facilitates the localization of the calcitonin-like receptor (CLR) to the plasma membrane, but its role in osteosarcoma (OS) remains unclear. We evaluated the RAMP1 expression and prognostic value across different cancers, studying tumor immune infiltration. The prognostic value was analyzed using the GSE39058 and TARGET datasets. Differential gene expression was evaluated. a protein-protein interaction network was constructed, and gene set enrichment analysis was performed. The function of RAMP1 in the tumor microenvironment was analyzed, and its expression in OS cell lines was validated using quantitative real-time PCR. High RAMP1 expression correlated with poor prognosis relative to low RAMP1 expression (p < 0.05). Low RAMP1 expression correlated with an abundance of CD4 + memory-activated T cells. whereas a high expression level correlated with a high proportion of gamma-delta T cells (γδ T cells). Differentially expressed genes from TARGET was enriched in olfactory transduction pathways (normalized enrichment scores [NES] = 1.6998, p < 0.0001). RAMP1 expression negatively correlated with CD44 expression but positively correlated with TNFSF9 expression. The RAMP1 gene is substantially expressed in OS cells compared to the normal osteoblast cell line hFOB1.19. Thus, RAMP1 may be a prognostic biomarker and potential therapeutic target in OS.
Clinical assessment of liraglutide use in prediabetic and obese schizophrenic patients: A systematic literature review and meta-analysis
Authors: Abbas Abdallah , Mektebi Ammar , El-Gayar Rawan Medhat , Hamad Abdullah Ashraf , Hefnawy Mahmoud Tarek , Rady Ahmed Hassan A. , Ballut Osama Omar , Moawad Mostafa Hossam El Din , Elsayed Mohamed E. G. , Schönfeldt-Lecuona Carlos 
Published: August 2023

Abstract
Background and Hypothesis Schizophrenic patients are at a higher risk of developing prediabetes and obesity, which may increase their risk of cardiovascular and other diseases. Liraglutide, a glucagon-like peptide-1 receptor agonist, is effective in treating prediabetes and obesity in the general population. However, its efficacy and safety in schizophrenic patients remain unclear. This study aims to evaluate the effectiveness of liraglutide in managing prediabetes and obesity among schizophrenic patients.Study Design A systematic PRISMA-based literature search was conducted in three electronic databases to identify eligible studies. Different treatment outcomes were extracted from the study and analyzed using a random-effects model to calculate the pooled effect size at 95% confidence interval. Heterogeneity was assessed using the I² statistic. Publication bias was evaluated using funnel plots and Egger's test. Subgroup and sensitivity analyses have been performed to explore the potential sources of heterogeneity.Study Results Five studies were included in the meta-analysis after the screening process. The pooled mean difference in body weight between the liraglutide group and the placebo group was − 4.09 kg (p = 0.0008), indicating a significant reduction in body weight with liraglutide. Similarly, the overall mean difference in BMI was − 0.92 (p < 0.00001), and the overall mean difference in waist circumference was − 3.65 cm (p = 0.02), both indicating significant reductions of weight under liraglutide treatment. Liraglutide also significantly reduced fasting glucose (overall mean difference of -9.23; p < 0.00001) and total cholesterol (overall mean difference of -19.00; p = 0.0003).Conclusions Liraglutide is effective in reducing body weight, BMI, waist circumference, fasting glucose, HbA1c, total cholesterol, systolic blood pressure, and diastolic blood pressure. Since liraglutide might have a protective effect on the metabolic syndrome in schizophrenic patients, the add-on administration of liraglutide could improve the quality of life of these patients in the long term.
The standard deviation of CT value may become a new way to predict pancreatic fistula: a single-center large sample data study
Authors: Zhang Jing , cai he , zhang man , wang xin , cai yunqiang , peng bing 
Published: August 2023

Abstract
Background
Postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy is one of the most difficult problems for surgeons. The main purpose of this study was to use preoperative imaging and other clinical data to better predict the occurrence of POPF.
Methods
From January 2017 to January 2022, the baseline data, intraoperative and postoperative outcomes of patients who underwent laparoscopic pancreaticoduodenectomy (LPD) in the Division of Pancreatic Surgery, Department of General Surgery, West China Hospital were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to analyze the predictive factors of pancreatic fistula after LPD. The receiver operating characteristic curve (ROC) was drawn and the area under the curve (AUC) was calculated to evaluate the predictive value of the predictors.
Results
A total of 381 patients' data were included in the final study, of which 35 patients (9.2%) had a clinically relevant POPF(CR-POPF). Univariate analysis showed the CR-POPF (+) group had higher BMI (23.69 ± 3.33 vs. 21.96 ± 3.01), larger pancreatic duct diameter (5.62 ± 4.58 mm vs. 4.17 ± 2.39 mm), and larger standard deviation of pancreatic CT value (16.26 ± 34.44 vs. 9.82 ± 2.14), compared with the CR-POPF (-) group ( all P < 0.05). Multivariate analysis showed that only BMI was an independent risk factor for CR-POPF (OR (1.345), P = 0.002)). The AUC for the standard deviation of pancreatic CT value to CR-POPF was 0.706.
Conclusions
BMI is an independent predictor of CR-POPF after LPD. The standard deviation of pancreatic plain CT may be a new and simple way to predict the risk of CR-POPF after LPD.
Handgrip strength on the unaffected side associated with cardiorespiratory fitness in male patients with stroke
Authors: Chen Yuan , Zhou Mingchao , Zha Fubin , Zhang Shaohua , Luo Jiao , Huang Meiling , Yang Qiangqing , Shan Linlin , Wang Yulong 
Published: August 2023

Abstract
Objectives
To investigate factors related to cardiorespiratory fitness in patients with stroke and explore the association between handgrip strength (HS) and peak oxygen utilization (VO2peak).
METHODS
The present study adopted a cross-sectional method. Seventy male patients who had been clinically diagnosed with ischemic or hemorrhagic stroke were recruited for this study. HS on the unaffected side (uHS) was measured using a hydraulic hand dynamometer and adjusted for body mass index (uHSBMI) and body surface area (uHSBSA). Concurrently, the VO2peak was measured using a cardiopulmonary exercise test system. Univariate, multiple linear regression analyses were used to evaluate the association between various participant characteristics and the VO2peak.
RESULTS
The average age of the 70 selected male patients was 51.6 ± 10.3 years. The Barthel Index (BI), uHS, uHSBMI, and uHSBSA were the independent predictors of VO2peak. The National Institutes of Health Stroke Scale (NIHSS), body mass index (BMI), and body surface area (BSA) were negatively correlated with the VO2peak. The estimation of VO2peak using linear regression, including age, BI, uHSBSA, and anaerobic threshold (AT) as independent variables, explained 65.5% of the variance in the VO2peak.
CONCLUSION
BMI- and BSA-adjusted uHS appear to be independent factors associated with cardiorespiratory fitness in male patients with stroke. The anaerobic threshold (AT) combined with uHSBMI/uHSBSA may provide a more reliable assessment of the aerobic capacity post-stroke. The measurement of handgrip strength is a simple, risk-stratifying method that may help determine the cardiorespiratory fitness of patients with stroke, but a larger study with diverse subjects is needed. This study was registered at the China Clinical Trials Center (registration number: ChiCTR2000035308) in Aug. 8th, 2020.
Effectiveness of Magnetic Resonance Imaging/Ultrasound-Guided Target Biopsy in Detecting Clinically Significant Prostate Cancer
Authors: Kurokawa Gaku , Mori Keiichiro , Sasaki Hiroshi , Nakano Juria , Takahashi Yusuke , Iwatani Kosuke , Urabe Fumihiko , Tsuzuki Shunsuke , Koike Yusuke , Sato Shun , Takahashi Hiroyuki , Miki Kenta , Kimura Takahiro 
Published: August 2023

Abstract
Background
We aimed to evaluate the effectiveness of magnetic resonance imaging/ultrasound (MRI-US)-guided fusion biopsy for the detection of clinically significant prostate cancer (CSPC) and analyze the features of those highly suspected of having PCa but shown to be negative in target biopsies (TB) in patients with prostate imaging reporting and data system (PI-RADS) 4 or 5 lesions on multiparametric MRI evaluations.
Methods
We retrospectively evaluated all patients who underwent MRI/transrectal ultrasound (TRUS)-guided fusion biopsies at our institution between April 2018 and April 2022. All patients with at least one PI-RADS 3 or higher lesions and prostate-specific antigen (PSA) ≤ 20 ng/mL were enrolled in our study and subjected to TB in the region of interest. CSPC was defined as grade group ≥ 2 (equivalent to a Gleason score of 3 + 4).
Results
The detection rates of CSPC were higher in patients who underwent systematic biopsy (SB) and TB (54%; 177/328) than in those who underwent SB alone (39%; 128/328). Statistically significant differences were noted in the detection of CSPC depending on age, prostate volume, PI-RADS score, PSA density (PSAD), number of biopsies obtained, lesion location, and ROI.
Conclusion
MRI/TRUS-guided fusion prostate biopsy increased the detection rate of CSPC. PCa was less likely to be detected in patients with a low PSAD, large prostate volume, past history of biopsies, and no family history among those with PI-RADS 4 or 5 lesions and should be considered in such patients and addressed by performing additional SB for improving the detection rate of CSPC.
Integrated Intelligent Supervisory Controller with Fractional Controller Design for Plant-wide Wastewater Treatment Plants
Authors: Sheik Abdul Gaffar , Dey Indranil , Ambati Seshagiri Rao , Kumar Arvind , Kumari Sheena , Bux Faizal 
Published: August 2023

Abstract
In this research, binary-level control topology is designed in which lower-level control frameworks with fractional order proportional integral (FPI) controllers are implemented to control dissolved oxygen (SO) in the last three aerobic bioreactors by regulating the air diffusers (KLa) and FLC is implemented for the plant-wide wastewater treatment process. In order to reduce the operational cost index (OCI) and effluent quality index (EQI), novel control combination frameworks are created utilizing a benchmark simulation model (BSM2PSFe) with a struvite unit as the base. This supervisory topology considers the ammonia in the sixth and seventh aerobic bioreactors as a feedback signal to alter the SO set-points (ABAC) in the lower level. On comparing open-loop with six control approaches (CS1, CS2, CS3, CS4, CS5, and CS6) by using different combinations of fractional FPI and FLC. The OCI and EQI are improved in the case of CS4 by 4.9% and 6.8%. Comparing the open loop with CS6, OCI is decreased by 10% with an improved EQI of 1.3%. For all the control scenarios, greenhouse gas flow rates are decreased. Ammonia, total nitrogen, and total phosphorus are improved by 79.2%, 5.8%, and 0.5% respectively.
Linking African ancestral substructure to prostate cancer health disparities
Authors: Gheybi Kazzem , Mmekwa Naledi , Lebelo Maphuti Tebogo , Patrick Sean M. , Campbell Raymond , Nenzhelele Mukudeni , Soh Pamela X. Y. , Obida Muvhulawa , Loda Massimo , Shirindi Joyce , Butler Eboneé N. , Mutambirwa Shingai B.A. , Bornman M. S. Riana , Hayes Vanessa M. 
Published: August 2023

Abstract
Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such exclude for significant ancestral diversity. Here, we investigate a series of epidemiological demographic and lifestyle risk factors for 1,387 men recruited as part of the multi-ethnic Southern African Prostate Cancer Study (SAPCS). We found poverty to be a decisive factor for disease grade and age at diagnosis, with other notably significant PCa associated risk factors including sexually transmitted diseases, erectile dysfunction, gynaecomastia, and vertex or complete pattern balding. Aligned with African American data, Black ethnicity showed significant risk for PCa diagnosis (OR = 1.44, 95%CI = 1.05-2.00), and aggressive disease presentation (ISUP ≥ 4: OR = 2.25, 95%CI = 1.49–3.40). New to this study, we demonstrate African ancestral population substructure associated PCa disparity, observing increased risk for advanced disease for the southern African Tsonga people (ISUP ≥ 4: OR = 3.43, 95%CI = 1.62–7.27). Conversely, South African Coloured were less likely to be diagnosed with aggressive disease overall (ISUP ≥ 3: OR = 0.38, 95%=0.17–0.85). Understanding the basis for PCa health disparities calls for African inclusion, however, lack of available data has limited the power to begin discussions. Here, focusing on arguably the largest study of its kind for the African continent, we draw attention to the contribution of within African ancestral diversity as a contributing factor to PCa health disparities within the genetically diverse region of southern Africa.
Clinical Significance of Mean Platelet Volume, Platelet Distribution Width, and Neutrophil-Lymphocyte Ratio in Children with Familial Mediterranean Fever
Authors: trabzon gul , Ergüven Müferet , İsançlı Didem Kizmaz , Yasa Emine Olcay 
Published: August 2023

Abstract
Background
Familial Mediterranean Fever (FMF) is an ethnic and autosomal recessive disorder characterized by recurrent attacks of fever and polyserositis. Recently, several studies have demonstrated the importance of platelet count and volume changes associated with chronic diseases. Mean platelet volume(MPV), platelet distribution width (PDW), and neutrophil/lymphocyte ratio are shown to be essential indicators in many diseases' activation periods. In this study, we aimed to investigate the changes in children with FMF in attacks and attack-free.
Materials and Methods
In this study, 150 patients had been diagnosed with FMF (90 girls, 60 boys), and 50 healthy subjects (29 male, 21 female) were included. Patients’ data were recorded separately according to under treatment with colchicine, in the attacks and attack-free periods retrospectively. Patients were scored as mild, moderate, and severe.
Results
MPV levels in patients with FMF were higher than in the healthy group, and MPV levels were significantly lower in attacks than in attack-free periods. This decline was more pronounced with increasing disease severity scores.
Conclusion
In conclusion, as an easy, inexpensive, and rapid method, MPV measurement is a supportive parameter in determining the severity of the disease and attacks in patients with FMF.
Experimental Study on Pore Water Pressure Characteristics of Saturated Silty Sand
Authors: Huang Chunhui , Lu Jilei , Lin Yunhong 
Published: August 2023

Abstract
In order to obtain the development of pore water pressure of silty sandy in the subway tunnel road bed, a series of dynamic triaxial tests were conducted using the GDS hollow cylindrical torsion shear instrument. The influences of different dynamic loads with different vibration frequencies, effective confining pressure and consolidation ratio were considered during the development of pore pressure. It is shown that the pore pressure development of saturated silty sand is mainly in the form of hyperbolic and S-shaped curves. The developed pore pressure models were established based on the test results, from which the corresponding parameters were also calibrated to provide a reference for the prediction of pore pressure development under cyclic loading.