bluuebunny/crossref_metadata_2025_split huggingface dataset:
Darolutamide (Nubeqa)
Authors: CADTH  
Published: January 2023

CADTH recommends that Nubeqa should be reimbursed by public drug plans for the treatment of metastatic castration-sensitive prostate cancer (mCSPC) if certain conditions are met.
Nubeqa should only be covered to treat patients with mCSPC who are eligible for chemotherapy and are in relatively good health (i.e., have good performance status). Patients should not have received androgen deprivation therapy (ADT) for metastatic disease for more than 6 months, completed ADT for nonmetastatic disease within the past year, or received other prior systemic therapies for mCSPC.
Nubeqa should only be reimbursed if used in combination with docetaxel and ADT and should not be given with other anticancer drugs. It should be prescribed by an oncologist with expertise in the management of prostate cancer, and the price of Nubeqa should be reduced.
The land–atmosphere feedback observatory: a new observational approach for characterizing land–atmosphere feedback
Authors: Späth Florian , Rajtschan Verena , Weber Tobias K. D. , Morandage Shehan , Lange Diego , Abbas Syed Saqlain , Behrendt Andreas , Ingwersen Joachim , Streck Thilo , Wulfmeyer Volker 
Published: January 2023

Abstract. Important topics in land–atmosphere (L–A) feedback research are water and energy balances and heterogeneities of fluxes at the land surface and in the atmospheric boundary layer (ABL). To target these questions, the Land–Atmosphere Feedback Observatory (LAFO) has been installed in southwestern Germany. The instrumentation allows comprehensive and high-resolution measurements from the bedrock to the lower free troposphere. Grouped into three components, atmosphere, soil and land surface, and vegetation, the LAFO observation strategy aims for simultaneous measurements in all three compartments. For this purpose the LAFO sensor synergy contains lidar systems to measure the atmospheric key variables of humidity, temperature and wind. At the land surface, eddy covariance stations are operated to record the energy distribution of radiation, sensible, latent and ground heat fluxes. Together with a water and temperature sensor network, the soil water content and temperature are monitored in the agricultural investigation area. As for vegetation, crop height, leaf area index and phenological growth stage values are registered. The observations in LAFO are organized into operational measurements and
intensive observation periods (IOPs). Operational measurements aim for long
time series datasets to investigate statistics, and we present as an example the correlation between mixing layer height and surface fluxes. The potential of IOPs is demonstrated with a 24 h case study using dynamic and thermodynamic profiles with lidar and a surface layer observation that uses the scanning differential absorption lidar to relate atmospheric humidity patterns to soil water structures. Both IOPs and long-term observations will provide new insight into exchange
processes and their statistics for improving the representation of L–A feedbacks in climate and numerical weather prediction models. The lidar component in particular will support the investigation of coupling to the
atmosphere.
Feedback optimizing model predictive control
Authors: Trodden Paul 
Published: January 2023

It is usually desirable to operate systems at economically optimal steady states. Traditionally this is achieved by taking a hierarchical approach to system-wide optimization and control: a steady-state optimization problem is solved to provide optimal setpoints for a lower-level controller to track; the lower-level controller typically employs feedback to reduce the effects of uncertainty. *Feedback optimization* refers to the idea where both functions are performed by one controller: the feedback controller is capable of implicitly tracking the optimal steady-state, without the need for separate optimization or external setpoints. Several proposals have been made, but a common drawback is the lack of constraint handling and performance during the transient.This talk will introduce feedback optimizing model predictive control (FOMPC) as a means to overcome this drawback. The FOMPC formulation is enabled by expressing the KKT conditions for steady-state optimality in subspace form, leading to a tracking (optimality) error that is a function of the measured system output and input rather than a pre-computed setpoint. This tracking error is augmented with a velocity form of the (linear) system dynamics, leading to a formulation and control law that achieves offset-free tracking of the a-priori unknown steady-state optimum and, simultaneously, a transient response that respects constraints and minimizes a quadratic performance criterion. Extensions to the robust case follow. We show how the application to a power system frequency control problem results in an optimal economic steady-state with transient performance that surpasses that of existing feedback optimization methods.
Last Chance Saloons for Natural Kind Realism
Authors: Chakravartty Anjan 
Published: January 2023

AbstractTraditionally, accounts of natural kinds have run the gamut from strongly conventionalist to strongly realist views. Recently, however, there has been a significant shift toward more conventionalist-sounding positions, even (perhaps especially) among philosophers interested in scientific classification. The impetus for this is a trend toward making anthropocentric features of categories, namely, capacities to facilitate human epistemic (and other) interests via inductive inference, central to an account of kinds. I argue that taking these features seriously is both defensible and compatible with conventionalism, but not compatible with a traditional realism about kinds specifically. Moreover, hopes of achieving compatibility by revising and extending kind realism—into what I call “hyperrealism”—face an insuperable dilemma. The news for realists is not all bad, however: though kind realism proves untenable, closely associated realisms underlying the objectivity of kind discourse may be viable nonetheless.
Sistem Pencantrikan untuk Meningkatkan Minat Belajar Seni Tari
Authors: Wardatuz Sobri  
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan minat siswa dalam pembelajaran seni tari dengan menggunakan system pencantrikan dan apa faktor-faktor yang mempengaruhi minat siswa IX-A dalam pembelajaran seni tari di SMP Negeri 5 Lumajang. Jenis penelitian ini adalah penelitian tindakan kelas dengan pendekatan kualitatif. Instrumen utama dalam penelitian ini adalah peneliti dibantu oleh alat pendukung seperti alat tulis dan kamera. Teknik pengumpulan data dilakukan dengan mengambil studi literatur, observasi dan wawancara. Proses analisis dimulai dengan menganalisis data dan memilih secara selektif, kemudian data ditampilkan dalam bentuk deskriptif. Hasil dari penelitian ini menunjukkan adanya peningkatan minat belajar seni tari pada siswa kelas IX-A SMP Negeri 5 Lumajang. Peningkatan tersebut tampak pada kualitas pada proses pembelajaran yang ditunjukkan oleh antusias, keaktifan dan keikut sertaan siswa ketika mengikuti pembelajaran materi pagelaran tari dengan system pencantrikan. Peningkatan pada kualitas hasil dapat dilihat dari peningkatan jumlah siswa pada saat sebelum pelaksanaan dan sesudah pelaksanaan Tindakan.
Особливості адміністративно-правового забезпечення реалізації прав осіб з інвалідністю
Authors: Легеза Є. О. , Лютіков П. С. 
Published: January 2023

Розглянуто структуру та зміст правової основи забезпечення реалізації прав осіб з інвалідністю. У статті висвітлено питання розкриття нормативно-правових актів щодо охорони прав осіб на прикладі дітей з інвалідністю. Детально розкрито розмежування дефініції термінів «адміністративно-правове забезпечення»; «охорона»; «захист», надається правова характеристика цих категорій з метою визначення сутності адміністративно-правового забезпечення реалізації прав осіб з інвалідністю. Констатовано, що держава має сприяти реалізації розумових, освітніх, професійних, фізичних здібностей дітей з інвалідністю, забезпечивши їх індивідуальну мобільність, доступність до всіх закладів і установ. Проте, як показує аналіз фактичного стану справ, в Україні порушення прав дітей з інвалідністю тривають. Діючі норми законодавчих актів щодо охорони їх на практиці не працюють. Це призводить до того, що цим суб’єктам адміністративних правовідносин доводиться самостійно захищати свої права та інтереси в адміністративному або судовому порядку. Інститут адміністративно-правової охорони прав дітей з інвалідністю залишається суто декларативною складовою адміністративного права через відсутність єдності в розумінні дефініцій «охорона» та «захист».
The Role of Christian Religious Education in the Recovery of Mental Disorders
Authors: Tan Yunus 
Published: January 2023

Background: Christian religious education is not only limited to scientific learning but also practiced in everyday life, one of which is in the recovery of mental disorders.

Objective: This study aims to determine the role of Christian religious education in the recovery of mental disorders.

Method: This research uses qualitative research methods with a descriptive approach, while data collection techniques are carried out with literature studies through the exploration of journals, books, and other information relevant to the study.

Results: The results showed that the role of Christian religious education in the recovery of mental disorders is as a guide to teach the meaning of life, to keep away those who trigger problems, to bring good hope, and to bring tranquility.

Conclusion: The results showed that the role of Christian religious education in the recovery of mental disorders is as a guide to teach the meaning of life, to keep away those who trigger problems, to bring good hope, and to bring tranquility.
Legal Protection of Online Investors on the Binomo App by Alert Task Force Investment Financial Services Authority
Authors: Suwandi Suwandi , Kusno Kusno , Toni Toni 
Published: January 2023

Background: Broadly speaking, an investment is a commitment to a certain amount of funds or other resources such as equipment, immovable assets, intellectual property rights, or expertise. Investments are made personally as well as by legal entities. Investment in general, has several objectives, the first, is to get a more decent life in the future, the second is to reduce inflationary pressures, and the third is to save taxes.

Objective: This study aims to find out as well as analyze the legal protection of online Investors on the Bonomo application by the investment alert task force of the financial services authority. As well as knowing and analyzing about.

Methods: This research belongs to the normative type of research. So it can be known that the legal protection of investors by brokerage companies has not been sufficiently able to accommodate the interests of investors.

Result: In Law Number 21 of 2011 concerning the Financial Services Authority (OJK Law), the authority and duty of the OJK are to supervise Financial Services Institutions (LJK) in the capital market sector, the non-bank financial industry sector (such as insurance, pension funds, financing companies, etc.) and starting in 2014 will also supervise the banking sector (Commercial Banks and People's Credit Banks).

Conclusion: Based on the above explanation, it can be concluded that the legal protection of investors by brokerage companies has not sufficiently accommodated the interests of investors.
Implementation of Law of the Republic of Indonesia Number 20 of 2001 Concerning Amendments to Law Number 31 of 1999 Concerning the Eradication of Corruption Crimes Against Selection Bribery Cases Independent Pathway Students
Authors: Supiyan Supiyan , Panjaitan Bernat , Siahaan Nimrot 
Published: January 2023

This study aims to find out and analyze the phenomenon of bribery cases for independent path student selection and find out and analyze about the factors causing and impacting corruption. This research belongs to the normative type of research. So it can be known that the act of bribery in the phenomenon of bribery cases of independent track students has a damaging impact that is as bad as the criminal act of bribery bribery that occurs in the public domain, so it is necessary to take concrete steps to criminalize the act of bribery. Bribery as stipulated in the UUTPK is very diverse, the threat of criminal penalties and fines regulated in it also varies, causing legal uncertainty in law enforcement and contrary to the principle of legality. In addition, corruption is caused by many factors, both political, legal, economic, organizational, and cultural. Economic factors, such as low salaries, losses suffered, poverty, and others are often considered the dominant factors.
Analisis Efektivitas JPO (Jembatan Penyeberangan Orang) di Jalan Pandanaran Kota Semarang
Authors: Suseno Dhony Priyo , Widiyastika Ardinia 
Published: January 2023

Abstract. Jembatan Penyeberangan Orang (JPO) merupakan salah satu fasilitas pejalan kaki yang ditempatkan sesuai dengan tingkat kebutuhan bagi pejalan kaki dan lalu lintas kendaraan yang melintas pada ruas jalan yang bersangkutan. Penilaian efektivitas JPO akan menggunakan tiga standar parameter peraturan yaitu; Surat Edaran Menteri PUPR No.02/SE/M/2018 tentang Pedoman Perencanaan Teknis Fasilitas Pejalan Kaki, Keputusan Direktur Jendral Perhubungan Darat dengan Nomor SK.43/AJ/007/DRJD/97 tentang Keselamatan dan Kenyamanan Bagi Pejalan Kaki, serta DPU Direktorat Jendaral Bina Marga. Tiga JPO di jalan Pandanaran kota Semarang terletak di depan toko Merbabu (JPO-I), sky bridge (JPO-II), dan RS. Hermina (JPO-III).
Penelitian ini menggunakan metode deskriptif kualitatif dengan data primer berupa observasi lapangan selama satu minggu. Hasil analisis menurut Surat Edaran Menteri PUPR bahwa JPO seharusnya berupa penyeberangan pelican dengan lapak tunggu. Hasil analisis menurut Keputusan Dirjen Perhubungan Darat yaitu; JPO-I tidak memenuhi syarat dengan persentase 40%, JPO-II memenuhi syarat dengan persentase 60%, dan JPO-III tidak memenuhi syarat dengan presentase 40%. Hasil analisis menurut DPU Direktorat Jendral Bina Marga yaitu; JPO-I memenuhi syarat dengan persentase 57,14%, JPO-II memenuhi syarat dengan persentase 57,14%, dan JPO- III tidak memenuhi syarat dengan persentase 42,85%. Berdasarkan syarat standar dan hasil kuisioner maka pembangunan JPO di jalan Pandanaran dikategorikan sebagai fasilitas penyeberangan yang tidak efektif.
Keywords: Efektivitas, JPO, Pejalan Kaki, Parameter, Pelican
Fracture Intensity Modelling in Rock Slopes and Field Representativeness Evaluation Using Discrete Fracture Networks
Authors: Rosada O. A. , Hernández-Carrillo R. , Beltrán G. I. 
Published: January 2023

Abstract
Defining the fracture intensity in DFN models is crucial since a good refinement level is required to represent the insitu rock slopes conditions adequately. Most estimates are expressed in terms of the number of discontinuities per unit length (P10). However, the area of discontinuities per unit volume (P32) seems more suitable for rock slopes modeling with DFN, given its volumetric conception. Some methodologies allow estimating P32 indirectly from P10, using simulated DFN models. In this work, P10 is obtained directly from surface measurements using a close-range photogrammetry device. Then, the effect of discordant geometric data of discontinuities in P10 estimation is addressed. Finally, DFN modeling with values of P10 was performed to evaluate the incidence in the assessment of P32 and the realistic representation of the discontinuities observed in situ. The results allowed establishing some relevant conclusions regarding the representativeness of discontinuities in rocky slopes, using simulated volumetric intensities in DFN modeling.
Nonlinear Flow Model for Rock Fracture Intersections and the Roles of the Intersecting Angle, Aperture and Fracture Roughness
Authors: Liu J. , Wang Z. C. , Qiao L. P. 
Published: January 2023

Abstract
There are multiple flow paths with different flow directions in fracture intersections. A general flow model synthetically describing the nonlinear flow behavior of multiple flow paths in different directions in two-dimensional fracture intersections was proposed for the analysis of fluid flow in rock fracture networks. Based on the flow simulations and experiments, regression functions in terms of each kind of geometric parameter were obtained to determine nonlinear coefficients. Through independent and comprehensive analysis, the quantitative relationships between the nonlinear coefficients of the fracture intersection flow model and multiple geometric parameters, such as the intersecting angle (θ), aperture (e), and roughness, were obtained. The parametric expressions of nonlinear flow models were verified by flow experiments of typical fracture intersections and simulated cases with complicated combinations of geometric parameters. It was proven that the parametric expressions of nonlinear flow models were capable of describing the nonlinear flow through fracture intersections. The results of this study show that fracture intersections have an obvious influence on the flow characteristics of different flow paths, which indicates that the influence of fracture intersections can enhance the hydraulic heterogeneity of fractured rock and need to be considered in the flow analysis of fracture networks.
Slope Stability Analyses of a Former Chalk Quarry Wall, Kent, UK
Authors: Ingram D. , Bottomley J. , Vazaios I. 
Published: January 2023

Abstract
A slope stability analyses utilizing LiDAR, photogrammetry, and Discrete Fracture Network (DFN) modelling has been conducted in a former chalk quarry in Kent, United Kingdom. Chalk cliffs excavated decades ago are a remnant of the quarrying process, and gradual rehabilitation and development of the quarry has seen the residential and mixed-use construction expand toward the cliff-lined boundary, necessitating an assessment of their stability. 3D photogrammetry and laser scanning using a drone allowed for the generation of a point cloud and accompanying colorized 3D mesh, which was used assess the rockmass and derive discontinuity orientations. Subsequent stereonet and kinematic analyses were conducted using Rocscience DIPS. The 3D mesh was used to derive fracture data to develop the DFN using Golder’s FracMan. This project has provided the opportunity to develop and directly apply a workflow utilizing state-of-the-art remote sensing techniques to DFN modelling for assessing rockmass and rockfall conditions in an active site for the rehabilitation of former quarry works.
Fracture Detection and Prediction Using Subsurface Data and Reservoir Analog
Authors: Djezzar Sofiane , Boualam Aldjia , Ouadi Habib , Laalam Aimen , Mouedden Nadia , Merzoug Ahmed , Chemmakh Abderraouf 
Published: January 2023

Abstract
The Mouydir basin is considered the less explored basin where only low-quality seismic 2D data is available. The negative wells were drilled on structures recognized through geological maps, gravity, and seismic refraction data. The Cambro-Ordovician is the main reservoir in the Mouydir basin. It is characterized by tight sandstone where the permeability ranges from 0.01 to 1 mD and porosity from 3% to 6% in the Cambrian and the Ordovician, respectively. A specific workflow is proposed to bring new insight and guide the future exploration in this basin using surface and subsurface data. The workflow includes surface data such as geological maps and digital elevation models and subsurface data such as gravity, seismic 2D, and core. The 3D fracture model is used to understand the fractures’ distribution, fractures’ connectivity, and fractures’ kinematics. The outcomes could be used to predict fractures’ extension and occurrence in the subsurface. The drilling of a horizontal pilot well perpendicular to the maximum horizontal stress could be a beginning of a new exploration era in Mouydir basin.
Discrete Fracture Network Modeling of a Giant, Naturally Fractured Carbonate Reservoir, Korolev Field, Kazakhstan
Authors: Earnest E. , Playton T. , Vitel S. , Hui R. 
Published: January 2023

Abstract
This study details characterization and Discrete Fracture Network (DFN) modeling of a naturally fractured carbonate reservoir with natural fractures and karst, or “non-matrix,” that are essential to production. Characterization of non-matrix follows a workflow where non-matrix is interpreted from image logs and core. Prediction of non-matrix intensity trends away from well control is performed using regression to identify covariance with static grid properties and modeled using Sequential Gaussian Simulation (SGS). DFNs are built to model fractures and karst with defined statistical distributions of orientation, size, aperture, and permeability. Several DFN realizations are created to capture uncertainty. A hybrid Embedded Discrete Fracture Model plus Dual Porosity Dual Permeability (DPDK) approach is employed for simulation. Each DFN is split into 3 different size bins, including “small” fractures upscaled and added to matrix; “medium” fractures upscaled and assigned to the DPDK grid; and “large” fractures and karst that are modeled as EDFM. The resulting EDFM+DPDK models are used in practice for forecasting and signposting primary production and IOR outcomes. This work highlights a workflow to incorporate fracture characterization with fracture prediction to build DFNs that are geologically robust, consistent with dynamic well test data, and application to EDFM+DPDK models for forecasting.
Use of Stochastic DFN-DEM Modelling for Overall and Inter-Ramp Slope Stability Analysis
Authors: Mathe N. L. , Ferentinou M. , Esmaeili K. 
Published: January 2023

Abstract
Geometric Discrete Fracture Network (DFN) models are constructed in this research project, where limited and insufficient field structural data were exploited statistically in terms of observed parameter distribution at the mine-scale perspective. The construction of a DFN model employing a disaggregate technique was suggested by descriptive statistics of intensities (P10), orientation and length. The DFN model was validated by field data. The calibrated DFN model was then exported in a two-dimensional Distinct Element Model (DEM) to assess the stability of a critical pit wall where the multiple block failures were recorded at the bench and inter-ramp slope scale. The DFN-DEM approach adopted in this study could model the slope stability state using the shear strength reduction (SSR) method. According to the results of the simulations, the critical strength reduction factor (SRF) values derived from each numerical simulation were highly dependent on the DFN geometry configuration, and the trace length. To quantify the uncertainty associated with the assumptions established during the DFN-DEM modelling process, a series of models were simulated with different DFN configuration. At the inter-ramp slope scale, the simulations were predominantly unstable (SRF≤1.0) over 30 DFN realisations. The probability of failure (PoF) averaged 70% with a mean safety factor of 0.93 for the simulated DEM slope models while using the LE method, an average PoF of 40% and mean safety factor of 1.08 were estimated.