bluuebunny/crossref_metadata_2025_split huggingface dataset:
Should I call psycho-oncology? Training nurses on psycho-oncological screening reduces uncertainties
Authors: Dreismann Lara , Schoknecht Karoline , Vogel Arndt , Zimmermann Tanja 
Published: June 2023

Abstract
Purpose
Psycho-oncological screening is required to identify distressed patients and direct them to psycho-oncological care. In practice, screening procedure and related communication are still insufficient due to various barriers on the side of the medical team. The aim of this study is to evaluate the specifically developed training (OptiScreen training) on screening from nurses’ perspective.

Methods
N = 72 nurses from visceral–oncological care at Hanover Medical School received the 6-h training, which consisted of three modules and targeted topics around screening, psycho-oncology and communication. The training was evaluated using a pre- and post-questionnaire assessing screening knowledge, uncertainties and further satisfaction outcomes.

Results
Personal uncertainties were significantly reduced by the training (t(63) = − 13.32, p < .001, d = 1.67). General satisfaction with the training was achieved (62.0–98.6% satisfied with the training elements). Feasibility (69%) and general acceptance (94.3%) for the training were rated positively.

Conclusion
The nurses rated the training as useful to reduce personal uncertainties regarding the screening process. Acceptability, feasibility and satisfaction with the training from the nursing perspective were achieved. The training contributes to minimizing barriers to inform about psycho-oncology and to recommend appropriate support services to patients.
Tetrahydrocannabinol (THC) bei Patienten mit Fibromyalgiesyndrom (FMS)
Authors: Bettstetter Horst , Schäfer Arne 
Published: June 2023

Zusammenfassung
Hintergrund
Seit dem 1. März 2017 ist medizinisches Cannabis (MC) bundesweit verschreibungsfähig. Zur Wirksamkeit von MC bei Fibromyalgiesyndrom (FMS) existieren bisher einige qualitativ unterschiedliche Studien.

Fragestellung
Ziel der Untersuchung war, die Wirksamkeit von Tetrahydrocannabinol (THC) im Verlauf einer IMST hinsichtlich des Schmerzes und mehrerer psychometrischer Variablen zu untersuchen.

Material und Methoden
Für die Studie wurden im Studienzeitraum (2017–2018) alle Patienten einer Schmerzstation, die an einem FMS erkrankt waren und in einem multimodalen, interdisziplinären Setting behandelt wurden, entsprechend den Einschlusskriterien selektioniert. Die Patienten wurden getrennt nach Gruppen mit und ohne THC-Medikation bzgl. der Schmerzintensität, verschiedener psychometrischer Parameter und des Analgetikaverbrauchs während des Aufenthalts untersucht.

Ergebnisse
Von den 120 in die Studie eingeschlossenen FMS-Patienten wurden 62 Patienten (51,7 %) mit THC behandelt. In den Parametern Schmerzintensität, Depressivität und Lebensqualität zeigte sich eine signifikante Besserung der Gesamtgruppe während des Aufenthalts (p < 0,001), die durch den Einsatz von THC signifikant stärker ausfiel. In fünf der sieben untersuchten Analgetikagruppen konnte bei den mit THC behandelten Patienten signifikant häufiger die Dosis reduziert bzw. das Medikament abgesetzt werden.

Schlussfolgerung
Die Ergebnisse liefern Hinweise dafür, dass THC als medikamentöse Alternative in Ergänzung zu den bisher in verschiedenen Leitlinien empfohlenen Substanzen für die Therapie des FMS in Betracht gezogen werden kann.
Simulation of bempedoic acid and ezetimibe in the lipid-lowering treatment pathway in Austria using the contemporary SANTORINI cohort of high and very high risk patients
Authors: Toplak Hermann , Bilitou Aikaterini , Alber Hannes , Auer Johann , Clodi Martin , Ebenbichler Christoph , Fließer-Görzer Evelyn , Gelsinger Carmen , Hanusch Ursula , Ludvik Bernhard , Maca Thomas , Schober Andreas , Sock Reinhard , Speidl Walter S. , Stulnig Thomas M. , Weitgasser Raimund , Zirlik Andreas , Koch Marina , Wienerroither Sebastian , Wolowacz Sorrel E. , Diamand Françoise , Catapano Alberico L. 
Published: June 2023

Summary
Objective
The low-density lipoprotein cholesterol goals in the 2019 European Society of Cardiology/European Atherosclerosis Society dyslipidaemia guidelines necessitate greater use of combination therapies. We describe a real-world cohort of patients in Austria and simulate the addition of oral bempedoic acid and ezetimibe to estimate the proportion of patients reaching goals.

Methods
Patients at high or very high cardiovascular risk on lipid-lowering treatments (excluding proprotein convertase subtilisin/kexin type 9 inhibitors) from the Austrian cohort of the observational SANTORINI study were included using specific criteria. For patients not at their risk-based goals at baseline, addition of ezetimibe (if not already received) and subsequently bempedoic acid was simulated using a Monte Carlo simulation.

Results
A cohort of patients (N = 144) with a mean low-density lipoprotein cholesterol of 76.4 mg/dL, with 94% (n = 135) on statins and 24% (n = 35) on ezetimibe monotherapy or in combination, were used in the simulation. Only 36% of patients were at goal (n = 52). Sequential simulation of ezetimibe (where applicable) and bempedoic acid increased the proportion of patients at goal to 69% (n = 100), with a decrease in the mean low-density lipoprotein cholesterol from 76.4 mg/dL at baseline to 57.7 mg/dL overall.

Conclusions
The SANTORINI real-world data in Austria suggest that a proportion of high and very high-risk patients remain below the guideline-recommended low-density lipoprotein cholesterol goals. Optimising use of oral ezetimibe and bempedoic acid after statins in the lipid-lowering pathway could result in substantially more patients attaining low-density lipoprotein cholesterol goals, likely with additional health benefits.
A novel mammarenavirus (family Arenaviridae) in hedgehogs (Erinaceus roumanicus) in Europe
Authors: Reuter Gábor , Boros Ákos , Takáts Károly , Mátics Róbert , Pankovics Péter 
Published: June 2023

AbstractIn this study, a novel mammarenavirus (family Arenaviridae) was identified in a hedgehog (family Erinaceidae) in Hungary and genetically characterized. Mecsek Mountains virus (MEMV, OP191655, OP191656) was detected in nine (45%) out of 20 faecal specimens collected from a Northern white-breasted hedgehog (Erinaceus roumanicus). The L-segment proteins (RdRp and Z) and S-segment proteins (NP and GPC) of MEMV had 67.5%/70% and 74.6%/65.6% amino acid sequence identity, respectively, to the corresponding proteins of Alxa virus (species Mammarenavirus alashanense) identified recently in an anal swab from a three-toed jerboa (Dipus sagitta) in China. MEMV is the second known arenavirus endemic in Europe.
Determination of trimetazidine in urine by capillary electrophoresis with amperometric detection
Authors: Baroch Martin , Dejmková Hana , Matysik Frank-Michael 
Published: June 2023

AbstractIn this contribution, nonaqueous capillary electrophoresis with end-column amperometric detection using a platinum ultramicroelectrode is presented along with several extraction procedures, both liquid–liquid extraction (LLE) and solid-phase extraction (SPE), for extracting trimetazidine from urine. Trimetazidine is an anti-ischemic drug, which changes hearth metabolism pathways and is being abused as a doping. Electrochemical detection in a nonaqueous environment provided a stable response with a relative standard deviation of only 3.6% (n = 10) in repeatability measurement at concentration of 50 µg cm−3. LOD and LOQ of the proposed method were determined as 0.054 µg cm−3 and 0.180 µg cm−3, respectively. From the point of view of LLE, the most efficient procedure was the double extraction with ethyl acetate as an extraction agent in combination with prior alkalinization of the sample by Na2CO3. Nevertheless, the extraction efficiency was only around 68%. The most efficient SPE procedure was based on the combination of HLB cartridge and elution with background electrolyte containing 20% of methanol. Its recovery reached up to 92% and 101% in case of 50 µg cm−3 and 5.0 µg cm−3 of trimetazidine in urine, respectively.
Graphical abstract
The benefits of mixed-mode chromatography columns for separation of peptides and protein digests
Authors: Kadlecová Zuzana , Boudová Hana , Kalíková Květa 
Published: June 2023

AbstractIn this work, the evaluation and comparison of mixed-mode chromatography and reversed-phase chromatography for separation of peptides and protein digests have been performed. The effects of pH of aqueous part of mobile phase as well as the effects of organic modifier on retention, resolution, and peak shape were investigated on several columns including three mixed-mode columns possessing reversed-phase/anion-exchange mechanism, two reversed-phase octadecyl columns, and one column with mixed-mode reversed-phase/anion-exchange character only in defined pH range. The set of peptides varying in their polarity, length, amino acid sequence, and charge state, namely dipeptides,N-blocked dipeptides, and oligopeptides, was selected to describe the chromatographic behavior under different conditions properly. These measurements showed the potential of mixed-mode chromatography columns for analysis of differently charged peptides in a single run. The applicability of the tested conditions has been verified by the analysis of cytochrome C digested fragments. Two types of samples were analyzed and compared, i.e., commercial cytochrome C digested standard and cytochrome C digested via trypsin spin columns. The obtained results point to the necessity of using mass spectrometry detection because of large number of unknown peaks in cytochrome C digested standard, probably originating from chymotryptic and miscleavage activities.Graphical abstract
Terrestrial Trentepohlia sp. (Ulvophyceae) from alpine and coastal collection sites show strong desiccation tolerance and broad light and temperature adaptation
Authors: Holzinger Andreas , Plag Niklas , Karsten Ulf , Glaser Karin 
Published: June 2023

AbstractFor the present study, we collected the Ulvophyceae species Trentepohlia aurea from limestone rock near Berchtesgaden, Germany, and the closely related taxa T. umbrina from Tilia cordata tree bark and T. jolithus from concrete wall both in Rostock, Germany. Freshly sampled material stained with Auramine O, DIOC6, and FM 1–43 showed an intact physiological status. Cell walls were depicted with calcofluor white and Carbotrace. When subjected to three repeated and controlled cycles of desiccation over silica gel (~ 10% relative humidity) followed by rehydration, T. aurea recovered about 50% of the initial photosynthetic yield of photosystem II (YII). In contrast, T. umbrina and T. jolithus recovered to 100% of the initial YII. HPLC and GC analysis of compatible solutes found highest proportions of erythritol in T. umbrina and mannitol/arabitol in T. jolithus. The lowest total compatible solute concentrations were detected in T. aurea, while the C/N ratio was highest in this species, indicative of nitrogen limitation. The prominent orange to red coloration of all Trentepohlia was due to extremely high carotenoid to Chl a ratio (15.9 in T. jolithus, 7.8 in T. aurea, and 6.6. in T. umbrina). Photosynthetic oxygen production was positive up to ~ 1500 µmol photons m−2 s−1 with the highest Pmax and alpha values in T. aurea. All strains showed a broad temperature tolerance with optima for gross photosynthesis between 20 and 35 °C. The presented data suggest that all investigated Trentepohlia species are well adapted to their terrestrial lifestyle on exposed to sunlight on a vertical substrate with little water holding capacity. Nevertheless, the three Trentepohlia species differed concerning their desiccation tolerance and compatible solute concentrations. The lower compatible solute contents in T. aurea explain the incomplete recovery of YII after rehydration.
RETRACTED ARTICLE: Clinical characterization of familial 1p36.3 microduplication
Authors: Jiao Junping , Wang Yuping , Hou Yue , Gao Chao , Shi Huimin , Tian Shujuan 
Published: June 2023

AbstractUnlike the 1p36 microdeletion syndrome, which has been extensively described, 1p36.3 microduplications have rarely been reported. We report the two siblings of familial 1p36.3 microduplication, presenting with a severe global developmental delay, epilepsy, and a few dysmorphic features. They were referred to moderate-to-severe developmental delay (DD) and intellectual disability (ID). Both were considered eyelid myoclonus with absence of epilepsy (Jeavons syndrome). The EEG is characterized by widespread 2.5–3.5 Hz spikes and spike slow complex wave, eye closure sensitivity, and photosensitivity. The children has same dysmorphic features, including mild bitemporal narrowing and sloping forehead, sparse eyebrows, hypertelorism, ptosis, strabismus, infraorbital creases, wide nasal bridge with bulbous nasal tip, dystaxia, hallux valgus, and flat feet. Family exome sequencing revealed a maternally inherited 3.2-Mb microduplication of chromosomal band 1p36.3p36.2. However, DNA purified from blood samples of either parent did not find evidence for a microduplication of 1p36 in somatic tissue, indicating that such a mutation might be carried in the germline of the parents as gonadal mosaicism. No other family members of the affected siblings’ parents were reported to be affected by the symptoms found.
A modified Rives–Stoppa technique with composite mesh (FLaPp) in large incisional hernia: a multicentric retrospective cohort study
Authors: Fei Landino , Munegato Gabriele , Allaria Alfredo , Catauro Antonio , Rosati Samanta , Giordano Flavio , Balestra Gabriella , Docimo Ludovico , Gambardella Claudio 
Published: June 2023

Summary
Background
Large incisional hernias (LIH) are challenging conditions, often necessitating complex surgical procedures such as transversus abdominis muscle release (TAR). We evaluated the feasibility and effectiveness of tension-free abdominal wall repair of LIH with an innovative modified Rives–Stoppa procedure employing a composite free lateral polypropylene (FLaPp) prosthesis.

Methods
Symptomatic patients affected by LIH and treated with FLaPp composite prosthesis between April 2010 and December 2016 were retrospectively analyzed. The FLaPp prosthesis is made up of two layers: an internal layer based on a polypropylene film that can be used in contact with the intestinal loops to address the posterior peritoneal defect, and an external layer based on a macroporous lightweight mesh, with which a classic repair according to Rives–Stoppa is carried out.

Results
Forty-three patients were enrolled in the study. All hernias were W3. Early complications were seroma (16.3%), hematoma (11.6%), wound infection (7.0%), and bowel injury (2.3%). Late complications were sinus tract (4.7%), occasional pain (2.3%), and stiff abdomen (9.3%). The median operative time was 126 min and median hospitalization was 8 days. At the median follow-up of 40 months (range 37.5–117), the recurrence rate was 9.3% (4/43).

Conclusion
Use of FLaPp mesh with a tension-free surgical approach is an effective strategy for managing LIH in selected cases with the presence of a posterior defect, with low rates of complications and recurrences.
Social networks and health behaviors during the COVID-19 pandemic: a qualitative study among older adults in the Netherlands
Authors: Steijvers Lisanne C. J. , Leeferink Floor , Brinkhues Stephanie , Hoebe Christian J. P. A. , Dukers-Muijrers Nicole H. T. M. 
Published: June 2023

Abstract
Aim
Social networks, all social relationships that people have, may influence people’s health behavior and well-being, which was evaluated in this qualitative study in older adults. Furthermore, we evaluated people’s needs for strengthening social networks.

Subject and methods
For this qualitative study, semi-structured interviews were conducted between May and July 2021 among 24 adults aged 60 years and older.

Results
Respondents provided information on social network structure (number and types of relations) and function (social support). They received informational support from friends, emotional support from their partner/spouse, and all types of support (including practical support) from family. Respondents stated that their health behavior was mainly influenced by a partner/spouse. Family and friends were mostly for socializing. To strengthen networks, in-person bilateral or small group interactions were preferred.

Conclusion
Family and friends were important social supporters and positively influenced health behaviors. This study emphasizes the importance of social networks in health promotion.
Nuts and berries from agroforestry systems in temperate regions can form the foundation for a healthier human diet and improved outcomes from diet-related diseases
Authors: Lovell Sarah Taylor , Krishnaswamy Kiruba , Lin Chung-Ho , Meier Nicholas , Revord Ronald S. , Thomas Andrew L. 
Published: June 2023

AbstractAgroforestry is a specific type of agroecosystem that includes trees and shrubs with the potential to yield nutrient-rich products that contribute to human health. This paper reviews the literature on the human health benefits of tree nut and berry species commonly associated with agroforestry systems of the United States, considering their potential for preventing certain diet-related diseases. Emphasis is placed on those diseases that are most closely associated with poor outcomes from COVID-19, as they are indicators of confounding health prognoses. Results indicate that tree nuts reduce the risk of coronary heart disease, and walnuts (Juglans species) are particularly effective because of their unique fatty acid profile. Berries that are grown on shrubs have the potential to contribute to mitigation of hypertension, prevention of Type II diabetes, and reduced risk of cardiovascular disease. To optimize human health benefits, plant breeding programs can focus on the traits that enhance the naturally-occurring phytochemicals, through biofortification. Value-added processing techniques should be selected and employed to preserve the phytonutrients, so they are maintained through the point of consumption. Agroforestry systems can offer valuable human health outcomes for common diet-related diseases, in addition to providing many environmental benefits, particularly if they are purposefully designed with that goal in mind. The food system policies in the U.S. might be reoriented to prioritize these food production systems based on the health benefits.
On their way to the north: larval performance of Hemigrapsus sanguineus invasive on the European coast—a comparison with the native European population of Carcinus maenas
Authors: Espinosa-Novo Noé , Giménez Luis , Boersma Maarten , Torres Gabriela 
Published: June 2023

AbstractThe Asian shore crab Hemigrapsus sanguineus has become invasive in North Europe and it co-occurs and competes with the native European shore crab Carcinus maenas. Both species develop through a feeding and dispersive larval phase characterised by several zoeal and a settling megalopa stage. Larvae of marine crabs are vulnerable to food limitation and warming has the potential to exacerbate the negative effects of food limitation on survival and growth. We quantified the combined effects of temperature and food limitation on larval performance (survival and growth) of H. sanguineus and we compared our results with those reported on performance of C. maenas larvae, under the same experimental design and methodology. Larvae from four females of H. sanguineus collected on Helgoland (North Sea) were experimentally reared from hatching to megalopa, at four temperatures (range 15–24 °C) and two food conditions (permanent vs. daily limited access to food). Larval survival of H. sanguineus was low at 15 °C and increased with temperature, in contrast to the high survival reported for C. maenas larvae in the range 15–24 °C. Food limitation reduced survival and body mass of H. sanguineus larvae at all temperatures, but without evidence of the exacerbating effect caused by high temperatures and reported for C. maenas. By contrast, high temperature (24 °C) mitigated the negative effect of food limitation on body mass on H. sanguineus larvae. Advantages of H. sanguineus over C. maenas appear especially under the increased temperatures expected from climate change.
Insulin Resistance Triggers Atherosclerosis: Caveolin 1 Cooperates with PKCzeta to Block Insulin Signaling in Vascular Endothelial Cells
Authors: Tan Jingjing , Li Xiaoguang , Dou Ning 
Published: June 2023

Abstract
Objective
To date, therapies for endothelial dysfunction have primarily focused on ameliorating identified atherosclerosis (AS) risk factors rather than explicitly addressing endothelium-based mechanism. An in-depth exploration of the pathological mechanisms of endothelial injury was performed herein.

Methods
Aortic caveolin 1 (Cav1) knockdown was achieved in mice using lentivirus, and AS was induced using a high-fat diet. Mouse body weight, blood glucose, insulin, lipid parameters, aortic plaque, endothelial injury, vascular nitric oxide synthase (eNOS), injury marker, and oxidative stress were examined. The effect of Cav1 knockdown on the content of PKCzeta and PI3K/Akt/eNOS pathway–related protein levels, as well as PKCzeta binding to Akt, was studied. ZIP, a PKCzeta inhibitor, was utilized to treat HUVECs in vitro, and the effect of ZIP on cell viability, inflammatory response, oxidative stress, and Akt activation was evaluated.

Results
Cav1 knockdown had no significant effect on body weight or blood glucose in mice over an 8-week period, whereas drastically reduced insulin, lipid parameters, endothelial damage, E-selectin, and oxidative stress and elevated eNOS levels. Moreover, Cav1 knockdown triggered decreased PKCzeta enrichment and the activation of the PI3K/Akt/eNOS pathway. PKCzeta has a positive effect on cells without being coupled by Cav1, and ZIP had no marked influence on PKCzeta-Akt binding following Cav1/PKCzeta coupling.

Conclusion
Cav1/PKCzeta coupling antagonizes the activation of PI3K on Akt, leading to eNOS dysfunction, insulin resistance, and endothelial cell damage.
Same but Different: Providing a Probabilistic Foundation for the Feature-Matching Approach to Similarity and Categorization
Authors: Poth Nina 
Published: June 2023

Abstract
The feature-matching approach pioneered by Amos Tversky remains a groundwork for psychological models of similarity and categorization but is rarely explicitly justified considering recent advances in thinking about cognition. While psychologists often view similarity as an unproblematic foundational concept that explains generalization and conceptual thought, long-standing philosophical problems challenging this assumption suggest that similarity derives from processes of higher-level cognition, including inference and conceptual thought. This paper addresses three specific challenges to Tversky’s approach: (i) the feature-selection problem, (ii) the problem of cognitive implausibility, and (iii) the problem of unprincipled tweaking. It subsequently supports key insights from Tversky’s account based on recent developments in Bayesian modeling of cognition. A novel computational view of similarity as inference is proposed that addresses each challenge by considering the contrast class as constitutive of similarity and selecting for highly informative features. In so doing, this view illustrates the ongoing promise of the feature-matching approach in explaining perception, generalization and conceptual thought by grounding them in principles of probabilistic inference.