bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter self‐learning feedforward compensation‐based active disturbance rejection for path‐following control of self‐driving forklift trucks
Authors: Xie Hui , Li Longqing , Song Xiaojing , Xue Wenchao , Song Kang 
Published: May 2023

AbstractIn this paper, for self‐driving forklift, a path‐following framework based on composite disturbance rejection that combines a cascaded active disturbance rejection controller and an online estimator of model parameters is proposed on the basis of a geometry feedforward controller. The model‐based cascaded active disturbance rejection control (ADRC), in particular, is composed of an outer‐loop controller and an inner‐loop controller, with the outer‐loop controller reducing lateral error by manipulating the desired heading direction and the inner‐loop controller achieving heading control by adjusting the steering angle. The unmodeled dynamics of the actual forklift motion are denoted as total disturbances, which can be timely estimated by the extended state observer (ESO). Moreover, to increase the transient response, a parameter self‐learning based geometry feedforward controller is designed in conjunction with the forklift characteristics. The stability analysis is presented and the effectiveness of the composite algorithm is quantitatively evaluated in experiments, demonstrating the superiority over the conventional pure pursuit algorithm and the only use of ADRC.
Promotion of degradative autophagy by 6‐bromoindirubin‐3′‐oxime attenuates neuropathy
Authors: Jaiswar Praveen , Bhate Mitali , Surolia Avadhesha 
Published: May 2023

AbstractDamage to the central or peripheral nervous system causes neuropathic pain. Endoplasmic reticulum (ER) stress plays a role in peripheral neuropathy. Increase in ER stress is seen in diabetic neuropathy. Inducers of ER stress also give rise to peripheral neuropathy. ER stress leads to the formation of autophagosome but as their degradation is also stalled during ER stress accumulation of autophagosomes is seen. Accumulation of autophagosomes has deleterious effects on cells. In the present study, we show that treatment with tunicamycin (TM) (ER stress inducer) in mice leads to peripheral neuropathy as assessed by Von Frey and Hot plate method. Administration of a promoter of autophagy viz. 6‐bromoindirubin‐3′‐oxime (6‐BIO) subsequent to ER stress induced by TM exhibits a decrease in peripheral neuropathy. 6‐BIO was also effective in reducing diabetic peripheral neuropathy. To understand the type of autophagy activated, SH‐SY5Y cells were treated with 6‐BIO after TM treatment. Levels of cathepsin D (CTSD), a marker for degradative autophagy was higher in cells treated with 6‐BIO after TM treatment compared to only TM‐treated SH‐SY5Y cells while levels of Rab8A,—a marker for secretory autophagy was reduced. Furthermore, in parallel during ER stress secretory, we noted increased levels of lysozyme in autophagosomes destined for secretion. Cells treated with 6‐BIO showed reduction of lysozyme in secretory autophagosomes. This shows that 6‐BIO increased degradative autophagy and reduced the secretory autophagy. 6‐BIO also reduced the caspase‐3 activity in 6‐BIO‐treated cells. Thus, 6‐BIO reduced neuropathy in animals by activating degradative autophagy and reducing the secretory autophagy.
How does board interlock network matter for sustainability? A social learning approach to corporate environmental performance
Authors: Zhao Yi , Lee Jegoo 
Published: May 2023

AbstractThe study proposes a social learning perspective for corporate environmental performance (CEP), drawing on the social network approach. We examine how a firm's board interlock connections affect its CEP through direct and indirect social learning processes. Moreover, we argue that a firm's board interlock ties to other well‐connected firms amplify the effects of social learning on CEP. Empirical analyses with a unique dataset of the S&P 1500 firms support our hypotheses. This research clarifies the network mechanisms underlying the firms' social learning on environmental performance. We also provide practical implications about boards as a reservoir for firms' learning of environmentally beneficial activities in inter‐corporate networks.
Highly textured and crystalline materials for rechargeable Li‐ion batteries
Authors: Choi Min‐Ju , Baek Ji Hyun , Kim Jae Young , Jang Ho Won 
Published: May 2023

AbstractTo build an environment‐friendly energy‐based society, it is important to develop stable and high‐performance batteries as an energy storage system. However, there are still unresolved challenges associated with safety issues, slow kinetics, and lifetime. To overcome these problems, it is essential to understand the battery systems including cathode, electrolyte, and anode. Using a well‐controlled material system such as epitaxial films, textured films, and single crystals can be a powerful strategy to investigate the relationship between microstructural and electrochemical properties. In this review, we discuss the need for research with well‐controlled materials system and recent progress in the well‐controlled cathode, solid‐state‐electrolyte, and anode materials for Li‐ion batteries. Enhanced stability and electrochemical performance due to the facilitation of prolonged and endured Li‐ion transport in facet‐controlled battery materials are highlighted. Finally, the challenges and future directions utilizing the well‐controlled battery system for high‐performance battery are proposed.
Utilizing induced neural stem cell‐based delivery of a cytokine cocktail to enhance chimeric antigen receptor‐modified T‐cell therapy for brain cancer
Authors: Woodell Alex S. , Landoni Elisa , Valdivia Alain , Buckley Andrew , Ogunnaike Edikan A. , Dotti Gianpietro , Hingtgen Shawn D. 
Published: May 2023

AbstractChimeric antigen receptor (CAR)‐modified T‐cell therapy has shown enormous clinical promise against blood cancers, yet efficacy against solid tumors remains a challenge. Here, we investigated the potential of a new combination cell therapy, where tumor‐homing induced neural stem cells (iNSCs) are used to enhance CAR‐T‐cell therapy and achieve efficacious suppression of brain tumors. Using in vitro and in vivo migration assays, we found iNSC‐secreted RANTES/IL‐15 increased CAR‐T‐cell migration sixfold and expansion threefold, resulting in greater antitumor activity in a glioblastoma (GBM) tumor model. Furthermore, multimodal imaging showed iNSC delivery of RANTES/IL‐15 in combination with intravenous administration of CAR‐T cells reduced established orthotopic GBM xenografts 2538‐fold within the first week, followed by durable tumor remission through 60 days post‐treatment. By contrast, CAR‐T‐cell therapy alone only partially controlled tumor growth, with a median survival of only 19 days. Together, these studies demonstrate the potential of combined cell therapy platforms to improve the efficacy of CAR‐T‐cell therapy for brain tumors.
3D scanning digital models for virtual museums
Authors: Barszcz Marcin , Dziedzic Krzysztof , Skublewska‐Paszkowska Maria , Powroznik Pawel 
Published: May 2023

AbstractA great number of virtual museums exhibit archaeological artifacts in an interactive form using 3D digital models to disseminate them to as many users as possible. Currently, 3D models obtained as a result of scanning museum objects have gained a great popularity. This technique allows to faithfully reproduce objects and to expose artifacts too delicate and precious to be presented in the real world. The aim of this article is to create a virtual museum in the VR world using 3D models obtained by 3D scanning with structured light. The advantages of optimizing mesh models for their use in virtual exhibitions are discussed. Unity and Unreal Engine, were used to create virtual museums in the VR world. Two twin test applications were prepared. This allowed to compare the performance of the developed applications (processor, graphics card, and RAM load). A survey was also conducted among the users of the implemented virtual museum application. For immersion in the world of VR, a low‐cost solution was used, involving the use of cheap VR frames, a smartphone, and a computer. The frames together with the smartphone were used to display the image, while the entire rendering process was performed on the computer.
A case of MDS/MPN overlap syndrome with ring sideroblasts and thrombocytosis: Tackling the quandary of thrombosis versus hemorrhage
Authors: Cherniawsky Hannah , Razavi Habib Moshref 
Published: May 2023

Key Clinical MessageNo formal treatment guidelines for MDS/MPN‐RS‐T exist. With salient features such as anemia and thrombocytosis, management is individualized and aims to address anemia, thrombosis, and in some cases acquired von Willebrand's disease.AbstractMyelodysplastic/myeloproliferative overlap syndrome with ring sideroblasts and thrombocytosis (MDS/MPN‐RS‐T) is a rare myeloid neoplasm showing myelodysplastic and myeloproliferative features. With extremely raised platelets, possibility of acquired von Willebrand and risk of hemorrhage is increased. With this quandary in mind, a descriptive case and a brief discussion of available treatments ensues.
Synchronous mixed medullary‐papillary carcinoma and papillary multifocal carcinoma of the thyroid with cervical lymph node metastases
Authors: Lalanda Raquel , Aparício David , Boavida João , Presa Dolores Lopes , Batista Lucas , Miranda Luís 
Published: May 2023

Key Clinical MessageThe occurrence of simultaneous multifocal papillary thyroid carcinoma and mixed medullary‐papillary carcinoma, as far as we know, has not been previously described. We suggest the surgical approach to be driven by the medullary component.AbstractPatient underwent total thyroidectomy with central compartment lymph node dissection. Histological examination revealed a simultaneous multifocal papillary thyroid carcinoma and mixed medullary‐papillary carcinoma. He was disease‐free at 1‐year‐follow‐up.
Application of Prussian Blue Analogue‐Derived Mn−Co Catalysts in the Hydrogenation of CO to Higher Alcohols
Authors: Telaar Pascal , Schmidt Stefan , Diehl Patrick , Schwiderowski Philipp , Muhler Martin 
Published: May 2023

AbstractMnxCo3‐x[Co(CN)6]2 Prussian blue analogues were synthesized with Mn : Co ratios in the range from 7 : 10 to 1 : 11 and pyrolyzed at 600 °C to obtain a highly nitrogen‐ and oxygen‐functionalized carbon matrix with embedded reduced Mn and Co species. These catalyst precursors were applied in the CO hydrogenation to higher alcohols at 260 °C and a pressure of 60 bar using a H2/CO ratio of 1. Metallic Co0 formed during pyrolysis was partially transformed into Co2C under reaction conditions. With increasing Co content CO conversion increased up to 10.6 % reaching a total alcohol selectivity of 19 %. Gas chromatograms revealed the expected formation of primary short‐chain alcohols, but also of secondary alcohols, acetic acid and propionaldehyde indicating olefin hydration, carbonylation and hydroformylation as reaction pathways, respectively. The obtained hydrocarbon fractions had a very high olefinicity, which is beneficial for both olefin hydration to secondary alcohols catalyzed by adsorbed carboxylic acids and for hydroformylation. Whereas the carbide‐based reaction pathway and the reductive hydroformylation are assumed to occur at the Co2C/Co0 interface, carbonylation is presumably catalyzed by an additional Co‐based active site. Thus, a unique class of multifunctional catalysts was obtained with highly promising properties bridging the gap between heterogeneous and homogeneous catalysis.
Supported Catalyst (nBuCp)2ZrCl2 on Nano/Micro Domains for High Performance Ethylene Polymerization
Authors: Moreno Ruiz Yolice Patricia , Moncada Edwin , Zimnoch dos Santos João H. 
Published: May 2023

AbstractSilica‐based supports known as structured‐mixed supports were evaluated in ethylene polymerization. These supports exhibit local surface heterogeneity due to the in situ growth of nanoparticles under the surface. Standard (N) and hybrid (NTw and NPu) nanosilicas were synthesized by a sol gel method. The metallocene (nBuCp)2ZrCl2 catalyst was immobilized onto nanosilicas and onto the structured‐mixed support (MN, MNTw, and MNPu). The zirconocene active sites on the nanoparticles exhibited high activity (5,071 kg.mol Zr−1.h−1.bar−1 with NPu) using Pluronic® L‐31 (Pu). An excellent catalytic performance (10,777 kg.mol Zr−1.h−1.bar−1) was achieved when Zr was incorporated on a structured‐mixed support, and a polymer with high molecular weight (Mw up to 224 kg.mol−1), broad polydispersion (Mw. Mn−1=3.1), high melting temperature (Tm=142 °C), and crystallinity (Xc=76 %) was generated using Tween®80 (Tw). The results showed that support characteristics, such as a large surface area, surface fractal structure, functionalization of nanoparticles with Tw or Pu, and nano/microdomains, influenced the nature and distribution of active sites, leading to a robust catalytic system that is easily synthesized. Silica‐based nano/microparticles pretreated with Tween®80 are an adequate candidate for new catalytic supports for ethylene polymerization.
Insights on advanced substrates for controllable fabrication of photoanodes toward efficient and stable photoelectrochemical water splitting
Authors: Hou Huilin , Shao Gang , Wang Yang , Wong Wai‐Yeung , Yang Weiyou 
Published: May 2023

AbstractConversion of solar energy into H2 by photoelectrochemical (PEC) water splitting is recognized as an ideal way to address the growing energy crisis and environmental issues. In a typical PEC cell, the construction of photoanodes is crucial to guarantee the high efficiency and stability of PEC reactions, which fundamentally rely on rationally designed semiconductors (as the active materials) and substrates (as the current collectors). In this review work, we start with a brief introduction of the roles of substrates in the PEC process. Then, we provide a systematic overview of representative strategies for the controlled fabrication of photoanodes on rationally designed substrates, including conductive glass, metal, sapphire, silicon, silicon carbide, and flexible substrates. Finally, some prospects concerning the challenges and research directions in this area are proposed.
Anion Effects on Spin Crossover Systems: From Supramolecular Chemistry to Magnetism
Authors: Zhao Sheng‐Ze , Zhou Hua‐Wei , Qin Chun‐Yan , Zhang Hao‐Zhe , Li Yong‐Hua , Yamashita Masahiro , Wang Shi 
Published: May 2023

AbstractThe field of anion supramolecular chemistry has received more and more attention in recent years. Anions with diverse types and geometries have been widely used for the synthesis of ionic spin crossover (SCO) complexes. This review is devoted to anion effects on the molecular, supramolecular structures and magnetic properties of discrete SCO compounds. Firstly, typical anions used in the synthesis of these compounds are briefly summarized according to their various geometries. This is followed by a collection of representative examples of anion‐based SCO compounds, whose SCO properties are analyzed in terms of supramolecular interactions, geometry and charge of anions. In the third part, anion effects on SCO complexes of different kinds of metal centers and ligands are outlined and finally remarks on the synthesis new type of ionic SCO complexes in the future are described.
Identification of erythropoietin mimetic peptide 1 linear form in a sealed vial and its administration study in horses for doping control purpose
Authors: So Yat‐Ming , Wong Jenny K. Y. , Wong April S. Y. , Tse Alice T. L. , Wan Terence S. M. , Ho Emmie N. M. 
Published: May 2023

AbstractThe erythropoietin mimetic peptide 1 linear form (EMP1‐linear), GGTYSCHFGPLTWVCKPQGG‐NH2, was identified in an unknown preparation consisting of white crystalline powder contained in sealed glass vials using ultrahigh performance liquid chromatography‐high‐resolution mass spectrometry (UPLC‐HRMS). The white crystalline powder, allegedly used for doping racehorses, was found to contain around 2% (w/w) of EMP1‐linear. EMP1‐linear can be cyclised in equine plasma at physiological temperature of 37°C by forming an intramolecular disulfide bond to give EMP1, which is a well‐known erythropoiesis stimulating agent that can bind to and activate the receptor for cytokine erythropoietin (EPO). Thus, EMP1‐linear is a prodrug of EMP1, which is a performance‐enhancing doping agent that can be misused in equine sports. In order to identify potential target(s) for detecting the misuse of EMP1‐linear in horses, an in vitro metabolic study using horse liver S9 fraction was performed. After incubation, EMP1‐linear mainly existed in its cyclic form as EMP1, and four N‐terminus truncated in vitro metabolites TYSCHFGPLTWVCKPQGG‐NH2 (M1), SCHFGPLTWVCKPQGG‐NH2 (M2), WVCKPQGG‐NH2 (M3) and VCKPQGG‐NH2 (M4) were identified. An intravenous administration study with the preparation of white crystalline powder containing EMP1‐linear was also conducted using three retired thoroughbred geldings. EMP1 was detectable only in the postadministration plasma samples, whereas the four identified in vitro metabolites were detected in both postadministration plasma and urine samples. For controlling the misuse of EMP1‐linear in horse, its metabolite M3 gave the longest detection time in both plasma and urine and could be detected for up to 4 and 27 h postadministration, respectively.
Diversity, seasonal abundance, and environmental drivers of chaetognath populations in North Inlet Estuary, South Carolina, USA
Authors: Stone Sarah E. , Stone Joshua P. 
Published: May 2023

AbstractChaetognaths (Phylum: Chaetognatha) are one of the most abundant phyla of zooplankton worldwide and play an important role in marine trophic interactions. Although the role of chaetognaths in global ecosystems is well understood, the spatial variation and environmental drivers of estuarine chaetognath populations is poorly understood. To provide the first known record of chaetognath species composition in a coastal estuary in the south‐eastern USA, chaetognaths were identified and quantified from zooplankton samples collected on a monthly basis in 2019 and 2020 from North Inlet Estuary in South Carolina. Parasagitta tenuis was the most abundant species of the five found, making up 33% of total abundance. The egg presence of these chaetognaths was further analyzed to gauge reproductive cycles. Abundance and egg presence were compared with surface and bottom measurements of temperature, salinity, and dissolved oxygen levels to determine the driving abiotic factors behind chaetognath's seasonal variability and reproductive cycles. Temperature, salinity, and dissolved oxygen all had low (r < ±.29), non‐significant correlations with abundance. Chaetognath egg production was most significantly associated with dissolved oxygen (p < .001) and seasonal changes in temperature (p < .001). Our initial findings indicate the continued abundance of chaetognath in a local estuary are dependent on abiotic factors that are strongly influenced by a changing climate.
Development of a tool to predict the risk of incident heart failure in a general population: the HUNT for HF risk score
Authors: Ofstad Anne Pernille , Brunborg Cathrine , Johansen Odd Erik , Mørkedal Bjørn , Fagerland Morten W. , Laugsand Lars Erik , Gullestad Lars L. , Dalen Håvard 
Published: May 2023

AbstractAimsCurrently, no incident heart failure (HF) risk score that is in regular use in a general population is available. We aimed to develop this and compare with existing HF risk scores.Methods and resultsParticipants in the third wave (2006–08) of the population‐based Trøndelag Health Study 3 (HUNT3) were included if they reported no previous HF. Any hospital diagnoses captured during follow‐up (until the end of 2018) of HF, cardiomyopathy, or hypertensive heart disease were assessed by an experienced cardiologist. Valid HF events were defined as symptoms/signs of HF and objective evidence of structural/functional abnormality of the heart at rest. The model was compared with slightly modified HF risk scores (the Health Aging and Body Composition HF risk score, the Framingham HF risk score, the Pooled Cohort equations to Prevent HF risk score, and NORRISK 2). Among 36 511 participants (mean ± SD age of 57.9 ± 13.3 years, 55.4% female), with a mean follow‐up of 10.2 ± 1.3 years, 1366 developed HF (incidence rate of 3.66 per 1000 participant years). Out of the 38 relevant clinical variables assessed, we identified 12 (atrial fibrillation being the strongest) that independently predicted an HF event. The final model demonstrated good discrimination (C statistics = 0.904) and calibration, was stable in internal validation, and performed well compared with existing risk scores. The model identified that, at enrolment, 31 391 (86%), 2386 (7%), 1246 (3%), and 1488 (4%) had low, low‐intermediate, high‐intermediate, and high 10‐year HF risk, respectively.ConclusionsTwelve clinical variables independently predicted 10‐year HF risk. The model may serve well as the foundation of a practical, online risk score for HF in general practice.Trial Registration: ClinicalTrials.gov Identifier: NCT04648852.
Measuring industrial green total factor productivity in the context of the “two‐carbon” target: A case study of energy revolution reform pilot area, China
Authors: Xue Yaozu , Fan Jun , Wu Zhifang , Xu Jiaxin 
Published: May 2023

AbstractSince the “double carbon” target was proposed in 2020, emissions reduction has become the focus of the Chinese government's work. Industrial development is a crucial factor contributing to the increase in carbon emissions. Therefore, implementing carbon reduction in the industrial sector is an important part of China's goal of “double carbon.” In this context, this paper uses a three‐stage data envelopment analysis model to calculate the green total factor productivity (GTFP) of 18 industry sectors in Shanxi Province. The results show that: (1) the external environment has influence on the GTFP of energy revolution reform pilot area industrial sectors, and the efficiency value of two industries is overestimated before excluding environmental factors; (2) the industry difference of GTFP is significant, among which pharmaceutical manufacturing industry has the greatest promoting effect on GTFP, and ferrous metal mining and dressing industry has the greatest inhibiting effect on GTFP; (3) there is a serious redundancy in R&D investment of energy revolution reform pilot area in China, and only six industries belong to zero redundancy. (4) To reflect the GTFP of various industrial sectors more clearly, this paper divides four industries: “Double‐high” industry, “High‐low” industry, “Low‐high” industry, and “Double‐low” industry.