bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peptide Stapling with Boronate Esters‐ A Reversible Folding of (Artificial) Peptide Chain to α‐Helix
Authors: Kijewska Monika , Wołczański Grzegorz , Światowska Marta , Kędziora Katarzyna , Pawlicki Miłosz , Stefanowicz Piotr 
Published: May 2023

AbstractStabilization of a peptide conformation via stapling strategy may be realized by the reversible or more often irreversible connection of side chains being in mutually appropriate geometry. An incorporation of phenylboronic acid and sugar residues (fructonic or galacturonic acid), attached to two lysine side chains via amide bonds and separated by 2, 3, or 6 other residues in the C‐terminal fragment of RNase A introduces the intramolecular interaction stabilizing the α‐helical organization. The boronate ester stapling is stabilized in mild basic conditions and may be switched off by acidification leading to unfolded organization of the peptide chain. We investigated the possibility of using switchable stapling by mass spectrometry, NMR and UV‐CD spectroscopies, and DFT calculations.
Tracking the Process of Domino Ring‐Opening and Coupling of Fused Imidazole and Direct Observation of Peroxide Intermediates
Authors: Wang Yu , Luo Mei‐Lian , Cai Jin , Zhang Tao , Wu Yu‐Jie , Song Ming‐Da , Liu Bin , Zeng Ming‐Hua 
Published: May 2023

Comprehensive SummaryA domino ring‐opening and coupling of imidazolyl annulated heterocycles 1 (1a: 4‐methyl‐1‐(1‐methyl‐1H‐benzo[d]imidazol‐2‐yl)‐4H‐ benzo[d]imidazo[1,5‐a]imidazole, 1b: 1‐(1,5‐dimethyl‐1H‐benzo[d]imidazol‐2‐yl)‐4,7‐dimethyl‐4H‐benzo[d]imidazo[1,5‐a]imidazole) with dioxygen was developed at solvothermal condition, leading to conjugated 1,2‐diamidoalkenes derivatives 2 ((E)‐ArCONHArC=CArNHCOAr (Ar: 1‐methyl‐1H‐benzo[d]imidazolyl (2a), 1,5‐dimethyl‐1H‐benzo[d]imidazolyl (2b))) as single crystals directly. The reaction process was tracked by electrospray ionization mass spectrometry (ESI‐HRMS) and a series of reaction intermediates are detected. 18O2 labeling experiment verified the source of oxygen in 2. Combining evidence from control experiments, nuclear magnetic resonance (NMR) tracking, and crystallography, a seven‐step reaction pathway involving oxygen addition, ring opening, Friedel‐Crafts alkylation, oxidation, and dehydration was proposed and further supported by DFT calculation.
Computationally modelling cell proliferation: A review
Authors: Barbosa M. I. A. , Belinha J. , Jorge R. M. Natal , Carvalho A. X. 
Published: May 2023

AbstractCell proliferation is vital for the development and homeostasis of the human body. For such to occur, cells go through the cell cycle during which they replicate their genetic material and ultimately complete cellular division, when one cell divides into two new cells with equal genetic material. However, if there are some errors or abnormalities during the cell cycle that disrupt the balance between cell death and proliferation, severe problems can occur, such as tumour development, which is currently one of the leading causes of death in the world. Nowadays, mathematical and computational models are used to understand and study several biological mechanisms and processes, namely cellular proliferation. Over the last forty‐five years, several models have attempted to describe cell proliferation and its regulation. Due to the complexity of the process, numerous assumptions and simplifications have been considered. This work presents a review of some of these models, focusing mainly on mammalian or generic eukaryotic models. Previously published continuum, discrete and hybrid approaches are presented and compared, in order to understand and highlight the relevance and capabilities of these models, their shortcomings and future challenges.
Redefining the learning mechanism in teaching‐learning‐based optimization and its applications for flowtime‐aware‐cost minimizing of the workflow in cloud
Authors: Ram Satya Deo Kumar , Srivastava Shashank , Mishra Krishn Kumar 
Published: May 2023

SummaryTeaching‐learning‐based optimization (TLBO) algorithm is a population‐based meta‐heuristic algorithm that was created to solve single‐objective optimization problems. The teaching‐learning mechanism of a classroom inspires it. TLBO suffers from weak exploration. As a result, its performance is not good for solving multimodal problems. To turn TLBO into a tool for solving multimodal problems and maintaining good diversity, we made significant modifications into the learning process of the fundamental TLBO. The proposed algorithm produces more diverse solutions and works better for solving multimodal problems. This newly created variant of TLBO is called “Intelligent‐Teaching‐Learning‐Based Optimization (I‐TLBO) algorithm.” I‐TLBO's performance is evaluated against the most recent standard benchmark function, CEC‐06, 2019, and it is discovered that I‐TLBO outperforms the other algorithms. After that, I‐TLBO was applied for flowtime‐aware‐cost minimization of the workflow executions in cloud datacenter. To solve these scheduling problems, I‐TLBO and other metaheuristic algorithms are simulated in CloudSim and tested over scientific workflows such as Inspiral, Montage, SIPHT, sample, Cybershake, and Epigenomics workflows. Finally, it is found that I‐TLBO reduces flowtime and cost both by 28.48%, 11.30%, 17.64%, 13.22%, 11.45%, and 14.71% in comparison to the second best performing algorithm while executing the standard workflow in cloud.
Analysis of P2P network system based on two‐stage service and failure repairability
Authors: Zhang Yukang , Ma Zhanyou , Liu Yilin , Wang Shunzhi 
Published: May 2023

SummaryAlong with the rapid development of the information technology revolution, P2P technology has been more and more widely and deeply researched in the field of mobile wireless, and mobile P2P has become an emerging and popular research field. The particularity of the mobile environment has extremely high requirements on the P2P network topology, resource transition paths and network security. In this paper, a two‐stage queueing model with negative customers and asynchronous failure is established based on a hybrid mobile network model combining the semi‐distributed topology and the fully‐distributed topology. Using the matrix‐geometric solution and Gauss‐Seidel iterative method, the probability distribution of the network model in steady‐state is obtained, and expressions for performance indicators such as the average number of peers in the two stages are given. Numerical experiments were conducted using programming software to analyze the effect of parameters on each indicator. The optimal parameters were solved by constructing the average cost unit time function and social benefit function to provide decision foundation for the mobile P2P network model.
Interface Adsorption and Aggregation Behavior of Sulfonate‐Based Anionic Silicone Surfactants in Aqueous Solution
Authors: Meng Lina , Wang Wenyu , Li Lei , Feng Shengyu 
Published: May 2023

AbstractA series of sulfonate silicone surfactants possessing different hydrophobic groups were synthesized. Their adsorption and thermodynamic parameters in aqueous solutions were investigated by surface tension measurements, conductivity, transmission electron microscopy (TEM) and dynamic light scattering (DLS). These sulfonate‐based anionic silicone surfactants exhibit significant surface activity and can reduce the surface tension of water to 19.6 mN m−1 at critical micelle concentration. The TEM and DLS results demonstrate that the three sulfonated silicone surfactants self‐assemble into homogeneous sized vesicle‐like aggregates in aqueous solution. Moreover, the size of the aggregates was determined to be in the range from 80 to 400 nm at 0.05 mol L−1.
Yield component QTLs identified by genome‐wide association mapping validated in a diverse tropical japonica × tropical japonica rice biparental mapping population
Authors: Eizenga Georgia C. , Rice Adam D. , Huggins Trevis D. , Shakiba Ehsan , Edwards Jeremy D. , Jackson Aaron K. , Jia Melissa H. , Ali M. Liakat 
Published: May 2023

AbstractThe Rice Diversity Panel 1 (RDP1) is a resource for genome‐wide association (GWA) studies to explore the five major rice (Oryza sativa L.) subpopulations indica, aus, aromatic, temperate japonica, and tropical japonica (TRJ). Previously collected phenotype data for yield‐related traits in RDP1 were reanalyzed using a recently released 4.8 million single nucleotide polymorphism (SNP) dataset to enhance GWA mapping precision. GWA mapping revealed numerous GWA quantitative trait loci (QTLs) that were specific to one or more subpopulations. Most southern US cultivars are classified tropical japonica (TRJ) or TRJ admixtures, thus TRJ was the focus for validating Rice Diversity Panel 1 GWA QTLs. Two diverse TRJ accessions, L‐202 originating from California, USA, and Trembese from Indonesia, were selected for developing a recombinant inbred line (RIL) population. This RIL population was phenotyped for 20 yield component traits, 16 of which were measured in RDP1, including six agronomic, six panicle architecture, and four seed traits. Genotyping with 1439 polymorphic markers and QTL mapping revealed 43 RIL QTLs. Examination of the GWA QTLs identified 163 GWA QTLs for the same or related traits co‐located with 37 RIL QTLs. A significant overlap was on chromosome 7 (21.8–25.4; 26.8–29.6 Mb) where the well‐known yield related genes, GRAIN WEIGHT7 (GW7) and FRIZZY PANICLE (FZP), respectively, are located and specific to TRJ. In this region, 10 RIL QTLs were co‐located with 36 GWA QTLs for panicle architecture or seed traits, especially secondary branching to increase the number of seeds. RIL QTLs co‐located with GWA QTLs are targets for developing SNP markers that can be utilized in cultivar development.
Antitumor activity of galaxamide involved in cell apoptosis and stemness by inhibiting Wnt/β‐catenin pathway in cervical cancer
Authors: Yang Guang , He Yunbiao , Chen Yingxing , Huang Zhihan , Huang Jieqiong , Ren Xinyi , Xu Shihai , Li Ping 
Published: May 2023

AbstractOur previous work reported that galaxamide, a cyclopeptide extracted from the seaweed Galaxaura filamentosa, showed antiproliferative activity against HeLa cells by MTT assay. In this study, the growth‐inhibitory effects of galaxamide in HeLa cells and xenograft mouse models were investigated. It was found galaxamide significantly inhibited cell growth, colony formation, migration, and invasion and induced cell apoptosis by inhibiting the Wnt signaling pathway in HeLa cells. RNA sequencing revealed that galaxamide regulated stemness by Wnt6 signaling pathway in HeLa cells. By analyzing The Cancer Genome Atlas database, Wnt6 was found to be negatively/positively correlated with stemness‐ and apoptosis‐related genes in human cervical cancer. Cancer stem‐like cells (CSCs) isolated and enriched from HeLa cells demonstrated elevated Wnt6 and β‐catenin genes compared with nonstem HeLa cells. After galaxamide treatment, CSCs showed abrogation of sphere‐forming ability, along with inhibition of stemness‐related and Wnt pathway genes. Galaxamide treatment was also accompanied by the induction of apoptosis in HeLa cells, which was consistent with the results in BALB/c nude mice. Our results provide evidence that suppression of stemness by downregulating the Wnt signaling pathway is the molecular mechanism by which galaxamide effectively inhibits cell growth and induces apoptosis in cervical cancer cells.
Diagnostic performance of endocytoscopy with normal pit‐like structure sign for colorectal low‐grade adenoma compared with conventional modalities
Authors: Suzuki Kenichi , Kudo Shin‐ei , Kudo Toyoki , Misawa Masashi , Mori Yuichi , Ichimasa Katsuro , Maeda Yasuharu , Hayashi Takemasa , Wakamura Kunihiko , Baba Toshiyuki , Ishda Fumio , Hamatani Shigeharu , Inoue Haruhiro , Yokoyama Kazunori , Miyachi Hideyuki 
Published: May 2023

AbstractObjectivesA “resect‐and‐discard” strategy has been proposed for diminutive adenomas in the colorectum. However, this strategy is sometimes difficult to implement because of the lack of confidence in differentiating low‐grade adenoma (LGA) from advanced lesions such as high‐grade adenoma or carcinoma. To perform real‐time precise diagnosis of LGA with high confidence, we assessed whether endocytoscopy (EC) diagnosis, considering normal pit‐like structure (NP‐sign), an excellent indicator of LGA, could have additional diagnostic potential compared with conventional modalities.MethodsAll the neoplastic lesions that were observed by non‐magnifying narrow‐band imaging (NBI), magnifying NBI (M‐NBI), magnifying pit pattern, and EC prior to pathological examination between 2005 and 2018 were retrospectively investigated. The neoplastic lesions were classified into two categories: LGA and other neoplastic lesions. We assessed the differential diagnostic ability of EC with NP‐sign between LGA and other neoplastic lesions compared with that of NBI, M‐NBI, pit pattern, and conventional EC in terms of sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (AUC).ResultsA total of 1376 lesions from 1097 patients were eligible. The specificity (94.9%), accuracy (91.5%), and area under the receiver operating characteristic curve (0.95) of EC with NP‐sign were significantly higher than those of NBI, M‐NBI, pit pattern, and conventional EC.ConclusionsEC diagnosis with NP‐sign has significantly higher diagnostic performance for predicting colorectal LGA compared with the conventional modalities and enables stratification of neoplastic lesions for “resect‐and‐discard” with higher confidence.
An additive‐free electrosynthesis of gold micro‐stars for sensitive electroanalysis of N‐Acetyl‐L‐cysteine compared to conventional gold nanoparticles
Authors: Guin Saurav K. , Lapiy Alexandra , Dempsey Eithne 
Published: May 2023

AbstractGold star (AuST), which is one of the important anisotropic gold structures, finds applications in catalysis, sensing, and photothermal therapy by virtue of its branches of high aspect ratio. The preparation of AuSTs can prove challenging as it requires stringent reaction condition(s) and solution composition including various chemical additives, which are not suitable for either disposal in the environment or use in health‐related studies. Furthermore, these chemical additives often cover the gold surface and hence cause interferences in the applications of AuSTs. In this work, we have reported a proof of concept for preparing AuSTs of monodispersed size on glassy carbon electrodes by developing a simple electrosynthesis method using an aqueous acid solution of chloroauric acid in the absence of any chemical additive, structure‐directing or surface‐protecting agent. This electrosynthesis strategy was developed by understanding the corresponding electrocrystallization mechanism and designing a suitable potentiostatic pulse strategy. The current response per unit area of the gold content for the oxidation of N‐Acetyl‐L‐cysteine was found to be superior on AuSTs compared to widely used citrate‐capped gold nanoparticles (cit‐AuNPs) and bare gold.
Evaluating microbial contaminations of alternative heating oils
Authors: Surger Maximilian J. , Mayer Katharina , Shivaram Karthik , Stibany Felix , Plum Wilfried , Schäffer Andreas , Eiden Simon , Blank Lars M. 
Published: May 2023

AbstractSince 2008, European and German legislative initiatives for climate protection and reduced dependency on fossil resources led to the introduction of biofuels as CO2‐reduced alternatives in the heating oil sector. In the case of biodiesel, customers were confronted with accelerated microbial contaminations during storage. Since then, other fuel alternatives, like hydrogenated vegetable oils (HVOs), gas‐to‐liquid (GtL) products, or oxymethylene ether (OME) have been developed. In this study, we use online monitoring of microbial CO2 production and the simulation of onset of microbial contamination to investigate the contamination potential of fuel alternatives during storage. As references, fossil heating oil of German refineries are used. Biodiesel blends with fossil heating oils confirmed the promotion of microbial activity. In stark contrast, OMEs have an antimicrobial effect. The paraffinic Fischer–Tropsch products and biogenic hydrogenation products demonstrate to be at least as resistant to microbial contamination as fossil heating oils despite allowing a diversity of representative microbes. Through mass spectrometry, elemental analysis, and microbial sequencing, we can discuss fuel properties that affect microbial contaminations. In summary, novel, non‐fossil heating oils show clear differences in microbial resistance during long‐term storage. Designing blends with an intrinsic resistance against microbial contamination and hence reduced activity might be an option.
Shaking‐table test results of a full‐scale free‐standing building with base sliding and rocking
Authors: Kang Jae‐Do , Kajiwara Koichi , Tosauchi Yusuke , Sato Eiji , Inoue Takahito , Kabeyasawa Toshimi , Shiohara Hitoshi , Nagae Takuya , Kabeyasawa Toshikazu , Fukuyama Hiroshi , Mukai Tomohisa 
Published: May 2023

AbstractThis paper present results of shaking‐table tests conducted in 2015 and 2018 on a free‐standing base sliding and rocking system, which allows sliding and uplifting. A full‐scale 10‐story reinforced concrete (RC) building equipped with cast iron plates on the bottom surface of the grade beams was used as a specimen for 2015 and 2018 experiments. In 2018, the static friction coefficients of the specimen were 0.48 and 0.49, which was higher than that of the rustproofed specimens in 2015. In the experiments of 2015 and 2018, the normalized base shear (NBS) values when the sliding length of the building reached ≥1 mm were 0.0035–0.1795 and 0.1744–0.2748, respectively. In the shaking‐table test corresponding to moderate earthquake motions, the 2018 specimen showed almost no lateral movement, whereas the 2015 specimen moved laterally. Therefore, more seismic energy was input into the specimen, and the maximum interstory drift ratio of the 2018 specimen was larger than that of the 2015 specimen. However, when the 50% amplitude excitation results of the 2015 seismic structural system are compared with those of the 2018 free‐standing structural system, the 2018 results are approximately 0.57 times smaller. Thus, a free‐standing structural system with cast iron plates to reduce earthquake energy could reduce damage to buildings. The 2018 specimen satisfies the concept of a free‐standing base sliding and rocking system that does not move laterally during small to moderate earthquake motions but moves laterally during strong earthquake motions to suppress structural damage.
Application of guar (Cyamopsis tetragonoloba L.) gum in food technologies: A review of properties and mechanisms of action
Authors: Tahmouzi Sima , Meftahizadeh Heidar , Eyshi Saba , Mahmoudzadeh Amin , Alizadeh Behnam , Mollakhalili‐Meybodi Neda , Hatami Mehrnaz 
Published: May 2023

AbstractWith the world continuing to push toward modernization and the consumption of processed foods growing at an exponential rate, the demand for texturizing agents and natural additives has also risen as a result. It has become increasingly common to use thickening agents in food products to modify their rheological and textural properties and enhance their quality characteristics. They can be divided into (1) animal derived (chitosan and isinglass), (2) fermentation produced (xanthan and curdlan), (3) plant fragments (pectin and cellulose), (4) seaweed extracts (agar and alginate), and (5) seed flours (guar gum and locust bean gum). The primary functions of these materials are to improve moisture binding capacity, modify structural properties, and alter flow behavior. In addition, some have another responsibility in the food sector, such as the main ingredient in the delivery systems (encapsulation) and nanocomposites. A galactomannan polysaccharide extracted from guar beans (Cyamopsis tetragonolobus), known as guar gum (GG), is one of them, which has a wide range of utilities and possesses popularity among scientists and consumers. In the world of modernization, GG has found its way into numerous industries for use in food, cosmetics, pharmaceuticals, textiles, and explosives. Due to its ability to form hydrogen bonds with water molecules, it imparts significant thickening, gelling, and binding properties to the solution as well as increases its viscosity. Therefore, this study is aimed to investigate the characteristics, mechanisms, and applications of GG in different food technologies.
Inadequate dietary diversity during pregnancy increases the risk of maternal anemia and low birth weight in Africa: A systematic review and meta‐analysis
Authors: Seid Awole , Dugassa Fufa Desta , Weldeyohannes Misrak , Tadesse Zuriyash , Fenta Selamawit Lake , Bitew Zebenay Workneh , Dessie Getenet 
Published: May 2023

AbstractInadequately diversified food consumption during pregnancy can lead to micronutrient deficiencies, which can affect maternal and newborn health outcomes. Previous studies on maternal dietary diversity have either been limited to a specific geographical region or consist entirely of systematic reviews, without meta‐analyses. Thus, this study aimed to determine the pooled estimate of the association between inadequate dietary diversity during pregnancy, maternal anemia, and low birth weight in Africa. A systematic review of observational studies published between January 2000 and April 2022 was undertaken using the Google Scholar, PubMed, and CINAHL databases. The PRISMA checklist was followed to present the results. Microsoft Excel was used to abstract the data. STATA version 17 was used to analyze the data, and a random‐effects meta‐analysis model was applied to compute the pooled estimates. The study was registered in PROSPERO with protocol number CRD42022320873. A total of 22 publications with 9,696 participants were included in the final meta‐analysis. The pooled adjusted odds ratio (AOR) for inadequate dietary diversity and maternal anemia was 2.15 (95% CI, 1.66–2.65), while that for low birth weight was 2.04 (95% CI, 1.46–2.63). The highest pooled estimate of maternal anemia was reported in Cameroon (AOR = 9.8, 95% CI: 1.68–17.92), followed by Ethiopia (AOR = 2.6, 95% CI: 1.95–3.25). Similarly, the pooled estimates of low birth weight were highest in Cameroon (AOR = 3.04, 95% CI: 1.19–4.88) and Ethiopia (AOR = 1.8, 95% CI: 1.29–2.39). In Africa, pregnant mothers with inadequate dietary diversity are two times more likely to develop anemia and low birth weight. Social protection policies that prioritize pregnant women, maternal nutrition promotion in the community, and dietary counseling during antenatal care visits, using national food‐based dietary guidelines, should be strengthened.