bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primordial follicles remaining in young cancer survivors who received chemotherapy
Authors: Ogino Nana , Wakimoto Yu , Nakagawa Kohei , Kamei Hidetake , Fukui Atsushi , Yoshiyasu Kanako , Hasegawa Akiko , Hirota Seiichi , Shibahara Hiroaki 
Published: June 2023

AbstractAimOvarian tissue cryopreservation (OTC) is performed for fertility preservation in cancer patients undergoing chemotherapy. Although anti‐Müllerian hormone is used as a marker for ovarian reserve, serum levels do not always correlate with the number of follicles. Additionally, the follicle development stage most affected by chemotherapy is unclear. We examined the association between serum anti‐Müllerian hormone levels and the number of remaining primordial follicles after chemotherapy, as well as which follicle stage is most affected by chemotherapy before ovarian cryopreservation.MethodsThirty‐three patients who underwent OTC were divided into the chemotherapy (n = 22) and non‐chemotherapy (n = 11) groups; their ovarian tissues underwent histological examination. Pathological ovarian damage induced by chemotherapy was assessed. Ovarian volumes were estimated from weights. We compared the number of follicles at each developmental stage as a percentage of primordial follicles between the groups. The relationship between serum anti‐Müllerian hormone level and primordial follicle density was analyzed.ResultsThe chemotherapy group had a significantly lower serum anti‐Müllerian hormone level, ovarian volume, and density of developing follicles than the non‐chemotherapy group. Serum anti‐Müllerian hormone levels correlated with primordial follicle density only in the non‐chemotherapy group. The chemotherapy group had significantly lower numbers of primary and secondary follicles.ConclusionsChemotherapy induces ovarian damage and follicle loss. However, serum anti‐Müllerian hormone level does not always reflect the number of primordial follicles after chemotherapy, and chemotherapy more significantly affects primary and secondary follicles than primordial follicles. Many primordial follicles remain in the ovary after chemotherapy, supporting OTC for fertility preservation.
Corporate Social Performance, Legitimacy, and the Choice of Foreign Partners by State‐Controlled Entities in the Global Extractive Industries
Authors: Symeou Pavlos C. , Kassinis George I. 
Published: June 2023

AbstractWe study the outcome of the decision of a state‐controlled entity (SCE) to form an international joint venture (IJV) with a foreign partner in the SCE's country. Focusing on the perspective of the host SCE, we propose that in its search for a partner, the SCE will evaluate the sociopolitical legitimacy effect of a candidate partner's corporate social performance (CSP). Thereby, the SCE will consider CSP an important selection criterion because of its legitimacy effect on the selection decision, the SCE, the IJV, and the host state in the eyes of salient local and international stakeholders. Moreover, the legitimacy effect of a candidate partner's CSP will further influence the decision outcome through its interaction with the level of corruption in the candidate partner's home country, the extant sociopolitical legitimacy of the host state, and the number of neighbouring countries of the host country participating in international multi‐stakeholder initiatives. We find support for our hypotheses using a novel sample of extractive industries IJVs between SCEs from 48 countries and 203 foreign partners from 22 countries for the period 2000–15.
Growth performance, antioxidant indexes, and the expression of genes were considerably promoted by dietary supplementation of alanyl‐glutamine and vitamin E in juvenile marine medaka in seawater acidification by carbon dioxide
Authors: Li Weifeng , Xu Youqing , Liu Fujuan , Zhang Qian , Tang Ni , Zheng Yimin , Ding Zhaokun 
Published: June 2023

AbstractThe experiment was conducted to study the effect of different dietary supplementation of alanyl‐glutamine dipeptide (AGD) and/or vitamin E (VE) on the growth performance, antioxidant indexes, and the expression of glutathione peroxidase (GPx) and peroxisome proliferator‐activated receptor α (PPARⱭ) genes in juvenile marine medaka (Oryzias melastigma) in seawater acidification. Seven groups of juvenile marine medaka in triplicate were studied in an ecosystem. One of them was in normal seawater (pH 8.1, pH control), and the others were in seawater acidification (pH 7.7) regulated by carbon dioxide (CO2). The juveniles were separately fed for 10 weeks using one of six different diets. The six diets were one control diet (basic feed) without supplements and the other diets with different amounts of additional AGD and/or VE. The juveniles were sampled randomly for analysis of a whole fish in week 0 and week 10. The results showed that different dietary supplementation of AGD and/or VE could considerably promote the growth performance, antioxidant indexes, and the expression of GPx and PPARα genes of juvenile marine medaka in seawater acidification. The optimal diet was D4, with additional AGD 5 g and VE 50 IU per kg of dried feed.
Age‐related changes in male ant sperm quality
Authors: Degueldre F. , Aron S. 
Published: June 2023

AbstractSperm cells age during storage in the male reproductive organs, which can lead ejaculate quality to decline dramatically over time. Such may pose a particular concern in species with constrained sperm supplies, where adult males cannot replenish their sperm reserves. In eusocial hymenopterans (i.e. ants, bees and wasps with permanent castes), males typically reach adulthood with a limited quantity of sperm, and their testes deteriorate shortly thereafter. In adult life, both sexes mate during a single reproductive event. While males die quickly after copulation, they persist posthumously via sperm stored in their mates' spermatheca, sometimes for decades. As a result of this mating system, males should experience intense selection pressure to produce and transfer high‐quality sperm. Using the black garden ant (Lasius niger) as a model system, we investigated whether the duration of storage in the accessory testes before copulation affected sperm quality. We found that there was no impact of male age on sperm number or viability and that sperm DNA fragmentation decreased rather that increased with age. These results highlight the extent to which male ants, and possibly other taxa with constrained sperm supplies, have evolved extremely specialized strategies to ensure reproductive performance.
Ecological genetics of local adaptation in Arabidopsis: An 8‐year field experiment
Authors: Oakley Christopher G. , Schemske Douglas W. , McKay John K. , Ågren Jon 
Published: June 2023

AbstractThere is considerable evidence for local adaptation in nature, yet important questions remain regarding its genetic basis. How many loci are involved? What are their effect sizes? What is the relative importance of conditional neutrality versus genetic trade‐offs? Here we address these questions in the self‐pollinating, annual plant Arabidopsis thaliana. We used 400 recombinant inbred lines (RILs) derived from two locally adapted populations in Italy and Sweden, grew the RILs and parents at the parental locations, and mapped quantitative trait loci (QTL) for mean fitness (fruits/seedling planted). We previously published results from the first 3 years of the study, and here add five additional years, providing a unique opportunity to assess how temporal variation in selection might affect QTL detection and classification. We found 10 adaptive and one maladaptive QTL in Italy, and six adaptive and four maladaptive QTL in Sweden. The discovery of maladaptive QTL at both sites suggests that even locally adapted populations are not always at their genotypic optimum. Mean effect sizes for adaptive QTL, 0.97 and 0.55 fruits in Italy and Sweden, respectively, were large relative to the mean fitness of the RILs (approximately 8 fruits/seedling planted at both sites). Both genetic trade‐offs (four cases) and conditional neutrality (seven cases) contribute to local adaptation in this system. The 8‐year dataset provided greater power to detect QTL and to estimate their locations compared to our previous 3‐year study, identifying one new genetic trade‐off and resolving one genetic trade‐off into two conditionally adaptive QTL.
Severe reactive infectious mucocutaneous eruption mimicking drug‐induced epidermal necrolysis triggered by norovirus
Authors: Sanfilippo Eric , Habeshian Kaiane , Cotton Colleen H. , Kirkorian Anna Yasmine 
Published: June 2023

AbstractReactive infectious mucocutaneous eruption (RIME) is an eruptive mucositis with varying degrees of cutaneous involvement presumed to be due to an immunologic response to various infectious pathogens. Most reported cases occur after a prodromal upper respiratory illness. We present a patient with a particularly severe case mimicking drug‐induced epidermal necrolysis found to be triggered by asymptomatic norovirus infection, a virus not previously reported in association with RIME.
Are there essential forms in the social domain?
Authors: Jansen Ludger 
Published: June 2023

AbstractTraditionally, nature has often been thought to be structured by essential forms providing the generic features of natural things and thus the foundations for scientific explanations. In contrast, human history and the social domain have been thought to be the realm of ever‐changing appearances, where contingency prevails. The paper argues that the existence of essential forms is compatible with the contingent, mind‐dependent and historical character of the social world, and that essential forms can also be found in the social domain. Two categories of entities are discussed that suggest themselves to be identified as social forms, namely social kinds and social identities. To this end, it is shown that standard arguments for the existence of essential forms also apply to the social domain, and objections to the existence of social forms are rebutted. Particular attention is paid to the explanatory appeal of social forms. The paper concludes by suggesting that, far from being oppressive, essential social forms are presupposed by liberating social practices.
Dialyzer reprocessing: Considerations and pitfalls for effective and safe hemodialysis
Authors: Thongsricome Thana , Eiam‐Ong Somchai , Tiranathanagul Khajohn 
Published: June 2023

AbstractBackgroundDialyzer reprocessing for dialyzer reuse in the same patient has been developed since the early time in hemodialysis history to save cost and time related to reassembling the new dialyzer during that time. The procedure can reduce the first‐use and allergic reactions from using incompatible cellulosic dialyzer membrane by altering some manufacturing chemicals.MethodsAll of established literatures regarding recent dialyzer reprocessing methods and considerations were extensively reviewed and summarized.ResultsDialyzer reprocessing can be performed by multiple protocols but involves common steps including bedside rinsing after use, cleaning, dialyzer testing to prevent excessive drop in dialyzer clearance and membrane integrity, high‐level disinfection or sterilization either by chemicals or heat, storage, and preparation for subsequent dialysis session by adequate rinsing to reduce the residual reprocessing chemical to the safe level. Compared with the single‐use strategy, evidence is conflicting for the mortality advantages or disadvantages of dialyzer reuse, with some showing increased mortality in patients receiving peracetic acid sterilization. Keys for the effective and safe dialyzer reuse involve strict adherence to specific manufacturer's protocol, adequate dialysis water quality complied with the Association for the Advancement of Medical Instrumentation standard, measurement of the total cell volume to prevent inadequate hemodialysis, and infectious control consideration. In the present era, single‐use strategy is increasingly adopted due to the decreased cost for dialyzer manufacturing. Environmental concerns of higher solid waste from dialyzer disposal in single‐use dialysis should be compared with the liquid waste from reprocessing chemicals along with plastic waste and cardboard in reuse dialysis.ConclusionDialyzer reprocessing with adequate regulation is considered as an acceptable option for cost‐effective hemodialysis, compared with the single‐use strategy.
The circulation of knowledge beyond the academia: On scholarly couplers at porous borders
Authors: Medina Leandro Rodriguez 
Published: June 2023

AbstractWith strong pressure to make academic research socially and economically relevant, academics face the problem of reconciling inherently academic products through which they are assessed (e.g. scientific articles) with other products that are often demanded by non‐academic social actors. These products, which we call scholarly couplers, make up an important part of academic work, often ignored or underestimated in evaluation instances. In this article, we show how these types of products articulate with traditional ones and argue that academic production should be observed (and evaluated) through heterogeneous product chains, fostering more diverse academic profiles.
Eigenstrain‐based analysis of why uniformly shot peened aluminium plates bend more in the rolling direction
Authors: Yan Miao Hong , Lévesque Martin , Gosselin Frédérick P. 
Published: June 2023

AbstractShot peen forming is a process widely used to shape aircraft components such as wing skins, yet its fundamental working is still crudely understood. It is understood that a light conventional peen forming treatment applied uniformly over an initially flat plate will induce isotropic in‐plane stretching of the surface layer and will thus lead to a panel curving with identical curvatures in all directions. However, [1] made the startling observation that uniformly peen formed aluminium plates of different aspect ratios all bent along their laminating direction irrespective of the peening direction. This experimental result is counterintuitive because the residual stresses due to the lamination process are 1 order to 2 orders of magnitude smaller than those induced by the shot peen forming treatment. In the present study, we apply the eigenstrain theory to estimate the effect of the different sources of anisotropy on uniformly peen formed aluminium plates. Potential sources of anisotropy included the plastic anisotropy of rolled aluminium, nonequibiaxial initial stresses that redistribute when their equilibrium is disturbed by peening, the geometry of the specimens and externally applied prestress. For the alloy and peening conditions considered, we show that plastic anisotropy had no discernible influence on the resulting shape of the peen formed specimens. Initial residual stresses, on the other hand, caused slightly larger bending loads in the rolling direction of the alloy. Although the magnitude of these loads was approximately 30 times smaller than peening‐induced loads, it was sufficient to overcome the geometric preference for rectangular sheets to bend along their long side and cause all unconstrained specimens to bend along the rolling direction instead. Our analysis highlights the importance of the history of the material that is being peened. Residual stresses already present in the part before peening must be considered to ensure good simulation predictions.
Complications of red cell exchange for anemia management in patients with transfusion‐dependent thalassemia
Authors: Wall Erika , Bolster Lauren 
Published: June 2023

AbstractBackgroundIn the Rare Blood Disorders clinic at the University of Alberta in Edmonton, red cell exchange (RCE) was utilized in transfusion‐dependent thalassemia (TDT) patients with severe iron overload despite oral chelation and no access to iron infusion pumps for parenteral chelation. It was hypothesized that RCE would be less iron loading compared to simple transfusion. The purpose of this study is to document observations of the potential risks and benefits of RCE in TDT patients.Study design and methodsTDT patients treated with RCE were identified and consented for enrolment according to local research ethics standards. Seven patients were enrolled in the study. Charts were retrospectively reviewed from the time of initiation of RCE to the time of the most recent RCE or clinic follow‐up. Outcomes were documented and analyzed by descriptive analysis.ResultsThe average age was 30 years. 85.7% were male. 100% were on oral chelation therapy and had hyperferritinemia at baseline. Outcomes included hepatic iron overload (5 of 7), cardiac dysfunction (3 of 7), worsening splenomegaly or extramedullary hematopoiesis (5 of 7), syncopal events during RCE (2 of 7), and new antibodies (1 of 7). Iron overload improved after escalated oral chelation, not in relation to RCE initiation.DiscussionWe hypothesize complications were higher than expected due to inadequate hematocrit increment and lack of suppression of ineffective erythropoiesis. With no observed benefit in iron status, and high complication rates, we did not find evidence to recommend RCE in patients with TDT. This case series is a hypothesis‐generating study on transfusion techniques in TDT.
“O Mar Está para Peixes?” – an Interactive Platform for Open Source Fishery Data in Rio De Janeiro State
Authors: Albernaz Diana Rocco , De Carvalho Lino Augusto Sander , Lange Priscila Kienteca , Santos Sérgio Ricardo Brito 
Published: June 2023

Despite the wide dissemination of information access, open data scarcity in fisheries science is still seen as a challenge. Thus, initiatives such as Sea Around Us and Fish Stats stand out. Particularly in developing countries, fishery data collection systems are precarious and there is a lack of national platforms to make fisheries data available. In Brazil, some states such as São Paulo and Santa Catarina have their own data repositories in web platforms, but there are limitations for dynamic queries. In addition, fisheries management based on the “Ecosystem Approach to Fisheries” (EAF) have been discussed and adopted, and environmental variables have been used as indicators to increase the robustness of fishery models. In this sense, the present work proposes a fishery data compilation platform named O mar está para peixes? (Are there fish in the sea?), which contains fishery data and fishery-related satellite remote sensing data (i.e. sea surface temperature, chlorophyll concentration) for the State of Rio de Janeiro, Brazil. The platform is divided in five sections: Fishery, Habitat, Map, Satellite and Download. These sections make data available for dynamic and personalized consultations, with the option of downloading the data. A standard spreadsheet developed for users to submit their own data is presented, with the goal of promoting participation and the collective construction of the platform. This is a new step towards the development of an EAF in Rio de Janeiro, which will potentially open the pathway for the integration of public agencies, research institutions, fishing industry and artisanal fishermen.
Synthetic Data Generation Using Generative Adversarial Network for Burst Failure Risk Analysis of Oil and Gas Pipelines
Authors: Mazumder Ram Krishna , Modanwal Gourav , Li Yue 
Published: June 2023

Abstract
Despite the pipeline network being the safest mode of oil and gas transportation systems, the pipeline failure rate has increased significantly over the last decade, particularly for aging pipelines. Predicting failure risk and prioritizing the riskiest asset from a large set of pipelines is one of the demanding tasks for the utilities. Machine learning (ML) application in pipeline failure risk prediction has recently shown promising results. However, due to safety and security concerns, obtaining sufficient operation and failure data to train ML models accurately is a significant challenge. This study employed a Generative Adversarial Network (GAN) based framework to generate synthetic pipeline data (DSyn) using a subset (70%) of experimental burst test results data (DExp) compiled from the literature to overcome the limitation of accessing operational data. The proposed framework was tested on (1) real data, and (2) combined real and generated synthetic data. The burst failure risk of corroded oil and gas pipelines was determined using probabilistic approaches, and pipelines were classified into two classes depending on their probability of failure: (1) low failure risk (Pf: 0–0.5) and (2) high failure risk (Pf: &gt;0.5). Two random forest (RF) models (MExp and MComb) were trained using a subset of 70% of actual experimental pipeline data, (DExp) and a combination of 70% of actual experimental and 100% of synthetic data, respectively. These models were validated on the remaining subset (30%) of experimental test data. The validation results reveal that adding synthetic data can further improve the performance of the ML models. The area under the ROC Curve was found to be 0.96 and 0.99 for real model (MExp) and combined model (MComb) data, respectively. The combined model with improved performance can be used in strategic oil and gas pipeline resilience improvement planning, which sets long-term critical decisions regarding maintenance and potential replacement of pipes.
The Rip1 intramembrane protease contributes to iron and zinc homeostasis in
Mycobacterium tuberculosis
Authors: Nelson Samantha J. , Williams John T. , Buglino John A. , Nambi Subhalaxmi , Lojek Lisa J. , Glickman Michael S. , Ioerger Thomas R. , Sassetti Christopher M. 
Published: June 2023

ABSTRACT

Mycobacterium tuberculosis
is exposed to a variety of stresses during a chronic infection, as the immune system simultaneously produces bactericidal compounds and starves the pathogen of essential nutrients. The intramembrane protease, Rip1, plays an important role in the adaptation to these stresses, at least partially by the cleavage of membrane-bound transcriptional regulators. Although Rip1 is known to be critical for surviving copper intoxication and nitric oxide exposure, these stresses do not fully account for the regulatory protein’s essentiality during infection. In this work, we demonstrate that Rip1 is also necessary for growth in low-iron and low-zinc conditions, similar to those imposed by the immune system. Using a newly generated library of sigma factor mutants, we show that the known regulatory target of Rip1, SigL, shares this defect. Transcriptional profiling under iron-limiting conditions supported the coordinated activity of Rip1 and SigL and demonstrated that the loss of these proteins produces an exaggerated iron starvation response. These observations demonstrate that Rip1 coordinates several aspects of metal homeostasis and suggest that a Rip1- and SigL-dependent pathway is necessary to thrive in the iron-deficient environments encountered during infection.

IMPORTANCE

Metal homeostasis represents a critical point of interaction between the mammalian immune system and potential pathogens. While the host attempts to intoxicate microbes with high concentrations of copper or starve the invader of iron and zinc, successful pathogens have acquired mechanisms to overcome these defenses. Our work identifies a regulatory pathway consisting of the Rip1 intramembrane protease and the sigma factor, SigL, that is essential for the important human pathogen,
Mycobacterium tuberculosis,
to grow in low-iron or low-zinc conditions such as those encountered during infection. In conjunction with Rip1’s known role in resisting copper toxicity, our work implicates this protein as a critical integration point that coordinates the multiple metal homeostatic systems required for this pathogen to survive in host tissue.