bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
Authors: Harvey Lisa A. , Glinsky Joanne V. , Chu Jackie , Herbert Robert D. , Liu Hueiming , Jan Stephen , Billot Laurent , Scivoletto Giorgio , Spooren Annemie I. , Seelen Henk A. , Ben Marsha , Tranter Keira , Chen Lydia W. , Rainey Donna , Rimmer Christine , Jorgensen Vivien , Di Natal Fernanda , Denis Sophie , Gollan Emilie J. , Tamburella Federica , Agostinello Jacqui , van Laake-Geelen Charlotte M. , Bell Chris , Lincoln Claire , Stolwijk Janneke M. , van der Lede Jessica , Paddison Sue , Oostra Kristine , Cameron Ian D. , Weber Gerard , Sherrington Catherine , Nunn Andrew K. , Synnott Emma-Leigh , McCaughey Euan , Kaur Jasbeer , Shetty Sachin 
Published: July 2023

Abstract
Study design
Protocol for a multi-centre randomised controlled trial (the SCI-MT trial).

Objectives
To determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI).

Setting
Fifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium.

Methods
A pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants’ perceptions about ability to perform self-selected goals, length of hospital stay and participants’ impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025.

Conclusions
The findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI.

Trial registration
ACTRN12621000091808 (1.2.2021).
Robust perovskite formation via vacuum thermal annealing for indoor perovskite solar cells
Authors: Penpong Kwanchai , Seriwatanachai Chaowaphat , Naikaew Atittaya , Phuphathanaphong Napan , Thant Ko Ko Shin , Srathongsian Ladda , Sukwiboon Thunrada , Inna Anuchytt , Sahasithiwat Somboon , Pakawatpanurut Pasit , Wongratanaphisan Duangmanee , Ruankham Pipat , Kanjanaboos Pongsakorn 
Published: July 2023

AbstractPerovskite materials are fascinating candidates for the next-generation solar devices. With long charge carrier lifetime, metal-halide perovskites are known to be good candidates for low-light harvesting. To match the irradiance spectra of indoor light, we configured a triple-cation perovskite material with appropriate content of bromide and chloride (FA0.45MA0.49Cs0.06Pb(I0.62Br0.32Cl0.06)3) to achieve an optimum band gap (Eg) of $$\sim$$
∼
1.80 eV. With low photon flux at indoor condition, minimal recombination is highly desirable. To achieve such goal, we, for the first time, combined dual usage of antisolvent deposition and vacuum thermal annealing, namely VTA, to fabricate a high-quality perovskite film. VTA leads to compact, dense, and hard morphology while suppressing trap states at surfaces and grain boundaries, which are key culprits for exciton losses. With low-cost carbon electrode architecture, VTA devices exhibited average power conversion efficiency (PCE) of 27.7 ± 2.7% with peak PCE of 32.0% (Shockley–Queisser limit of 50–60%) and average open-circuit voltage (Voc) of 0.93 ± 0.02 V with peak Voc of 0.96 V, significantly more than those of control and the vacuum treatment prior to heat.
Life table study of Sitotroga cerealella on different cereals and its implications on the performance of the egg parasitoid (Trichogramma chilonis) under laboratory conditions
Authors: Salim Muhammad , Ullah Imdad , Saljoqi Ahmad Ur Rahman , Gökçe Ayhan , Ahmad Sarir , Almutairi Mikhlid H. , Sayed Amany A. , Aleya Lotfi , Abdel-Daim Mohamed M. , Shah Muddaser 
Published: July 2023

AbstractSitotroga cerealellais one of the major pests of cereals in the field and storage conditions throughout the world. The main objective was to study the life tables ofS. cerealellaon wheat, maize and barley and its implications on percent parasitism ofTrichogramma chilonis.S. cerealellais reared under lab conditions as its eggs are utilized for rearingT. chilonis. Fresh eggs ofS. cerealellawere collected and after hatching the neonate larvae ofS. cerealellawere transferred onto each host plant species for obtaining first (F1) generation (G). Seventy eggs were used for each host and each egg was used as a replicate. Daily observations were made for recording the life-table parameters of theS. cerealella. The data showed that the developmental time ofS. cerealellaeggs and pupae was maximum (5.68 and 7.75 days) when reared on wheat, while the maximum larval duration (19.77 days) ofS. cerealellawas recorded on barley. The maximum fecundity (290.30 ± 22.47 eggs/female) was recorded on maize, while minimum fecundity per female was recorded on barley (159.30 eggs/ female). TheS. cerealellareared on maize had significantly higher values of finite rate of increase(λ),intrinsic rate of increase (r),and net reproductive rate (Ro)(0.14 ± 0.04 day− 1, 1.16 ± 0.05 day− 1, and 136.85 ± 20.25 eggs/ female) respectively. The mean generation time (T) (35.18 ± 0.61 days) was higher on wheat. Likewise, the gross reproductive rate (GRR) and the age-stage specific reproductive values (vxj) of newly oviposited eggs ofS. cerealellawere recorded higher (136.85 ± 20.25; 1.160 offspring) on maize. The data regarding the efficacy ofT. chilonisfor different parameters were recorded higher on maize i.e., percent parasitism (89.00 ± 2.30%), percent adult emergence (81.60 ± 1.20%), adult longevity (3.80 ± 0.10 days) and total adult longevity (9.90 ± 0.20 days) as compared to wheat and barley. Our findings revealed thatS. cerealellacan be best reared on maize under laboratory conditions as it prefers this host as compared to wheat and barley. Therefore, assigning the most susceptible and favorite host (maize) would help us to improveT. chilonismass production under laboratory conditions.
Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma
Authors: Yang Katherine S. , O’Shea Aileen , Zelga Piotr , Liss Andrew S. , Del Castillo Carlos Fernandez , Weissleder Ralph 
Published: July 2023

AbstractIncreased use of cross-sectional imaging has resulted in frequent detection of incidental cystic pancreatic lesions. Serous cystadenomas (SCAs) are benign cysts that do not require surgical intervention unless symptomatic. Unfortunately, up to half of SCAs do not have typical imaging findings (“atypical SCAs”), overlap with potentially malignant precursor lesions, and thus pose a diagnostic challenge. We tested whether the analysis of circulating extracellular vesicle (EV) biomarkers using a digital EV screening technology (DEST) could enhance the discrimination of cystic pancreatic lesions and avoid unnecessary surgical intervention in these atypical SCAs. Analysis of 25 different protein biomarkers in plasma EV from 68 patients identified a putative biomarker signature of Das-1, Vimentin, Chromogranin A, and CAIX with high discriminatory power (AUC of 0.99). Analysis of plasma EV for multiplexed markers may thus be helpful in clinical decision-making.
Role of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression
Authors: Ye Bingyu , Yu Mengli , Yue Meijuan , Yin Man , Zhang Chunyan , Wang Qiwen , Ding Xinru , Shen Wenlong , Zhao Zhihu 
Published: July 2023

AbstractLiver fibrosis is caused by chronic hepatic injury and may lead to cirrhosis, and even hepatocellular carcinoma. When hepatic stellate cells (HSCs) are activated by liver injury, they transdifferentiate into myofibroblasts, which secrete extracellular matrix proteins that generate the fibrous scar. Therefore, it is extremely urgent to find safe and effective drugs for HSCs activation treatment to prevent liver against fibrosis. Here, we reported that PDZ and LIM domain protein 1 (PDLIM1), a highly conserved cytoskeleton organization regulator, was significantly up-regulated in fibrotic liver tissues and TGF-β-treated HSC-T6 cells. Through transcriptome analysis, we found that knockdown of PDLIM1 resulted in a significant downregulation of genes related to inflammation and immune-related pathways in HSC-T6 cells. Moreover, PDLIM1 knockdown significantly inhibited the activation of HSC-T6 cells and the trans-differentiation of HSC-T6 cells into myofibroblasts. Mechanistically, PDLIM1 is involved in the regulation of TGF-β-mediated signaling pathways in HSCs activation. Thus, targeting PDLIM1 may provide an alternative method to suppress HSCs activation during liver injury. CCCTC-binding factor (CTCF), a master regulator of genome architecture, is upregulated during HSCs activation. PDLIM1 knockdown also indirectly reduced CTCF protein expression, however, CTCF binding to chromatin was not significantly altered by CUT&Tag analysis. We speculate that CTCF may cooperate with PDLIM1 to activate HSCs in other ways. Our results suggest that PDLIM1 can accelerate the activation of HSCs and liver fibrosis progression and could be a potential biomarker for monitoring response to anti-fibrotic therapy.
Relationship between asymmetric nostril use and human emotional odours in cats
Authors: d’Ingeo Serenella , Siniscalchi Marcello , Straziota Valeria , Ventriglia Gianluca , Sasso Raffaella , Quaranta Angelo 
Published: July 2023

AbstractCat social behaviour and cognition has received a growing interest during the last decades. Recent studies reported that cats efficiently engage in interspecific communication with humans and suggest that cats are sensitive to human emotional visual and auditory cues. To date, there is no evidence on the social and informative role of human emotional odours, which may affect human-cat communication. In this study, we presented cats with human odours collected in different emotional contexts (fear, happiness, physical stress and neutral) and evaluated the animals’ behavioural responses. We found that “fear” odours elicited higher stress levels than “physical stress” and “neutral”, suggesting that cats perceived the valence of the information conveyed by “fear” olfactory signals and regulate their behaviour accordingly. Moreover, the prevalent use of the right nostril (right hemisphere activation) with the increase of stress levels, particularly in response to “fear” odours, provides first evidence of lateralized emotional functions of olfactory pathways in cats.
Verletzungen der proximalen und distalen Bizepssehne
Authors: Otto Alexander , Fritsch Lorenz , Kadantsev Pavel , Siebenlist Sebastian 
Published: July 2023

ZusammenfassungDer M. biceps brachii besitzt 2 proximale Ursprünge und einen distalen Ansatz. Dabei kann die lange Bizepssehne (LBS) häufig als Ursache für den vorderen Schulterschmerz identifiziert
werden. Zahlreiche Pathologien wie eine Tendinitis, (Partial-)Risse oder Subluxation der LBS sind dafür grundlegend. Rupturen der Rotatorenmanschette stellen dabei auch ursächliche
Veränderungen für Beschwerden der LBS dar. Scheitert die konservative Therapie, kann entsprechend dem körperlichen Anspruch eine Tenotomie resp. Tenodese der LBS erfolgen. Sowohl supra-
als auch subpektorale LBS-Tenodesen führen dabei zu guten funktionellen Ergebnissen. Die LBS-Tenotomie kann bei Patienten mit geringeren funktionellen Anforderungen angewandt werden,
jedoch mit einem höheren Risiko für eine postoperative Distalisierung des Muskelbauchs des Biceps brachii.Die distale Bizepssehne (DBS) ist der wichtigste Supinator des Unterarms und fungiert als sekundärer Flexor des Ellenbogens. Rupturen der DBS treten am häufigsten bei Männern mittleren
Alters im Rahmen eines traumatischen Ereignisses auf. Bei körperlichem Anspruch mit relevantem Defizit von Supinationskraft und -ausdauer ist die chirurgische Versorgung indiziert.
Verschiedene Operationstechniken sind zur Refixation der DBS beschrieben. In unserer Praxis hat sich die unikortikale Onlay-Refixation sowohl mit dem Kortikalis-Button als auch mit
All-Suture-Ankern bewährt. Bei chronischen Rupturen der DBS kann eine Augmentation durch ein Transplantat durchgeführt werden.Dieser Artikel bietet einen umfassenden Überblick über Therapie von proximalen und distalen Sehnenrupturen des Biceps brachii.
Aktueller Stand zu Verletzungen der proximalen und distalen Hamstring-Sehnen
Authors: Otto Alexander , Fenwick Annabel , Wiedl Andreas , Mayr Edgar 
Published: July 2023

ZusammenfassungDie ischiokrurale Muskulatur, auch Hamstring-Muskulatur genannt, überspannt sowohl das Hüft- als auch das Kniegelenk und erleidet während sportlicher Aktivitäten häufig Verletzungen.
Sehnenverletzungen der Hamstring-Muskulatur sind eine seltenere Entität als die Verletzung der Muskulatur selbst.Allerdings kann insbesondere die Avulsion der proximalen Hamstring-Sehnen zu immobilisierenden Beschwerden mit fortwährender Einschränkung der Sportfähigkeit führen. Entsprechend dem
individuellen körperlichen und sportlichen Anspruch erfolgt die weiterführende Therapie dieser klinisch relevanten Verletzung. Im Rahmen der operativen Versorgung erfolgt eine Refixation
der proximalen Hamstring-Sehnen am Tuber ischiadicum. Die operative Therapie zeigte eine signifikant höhere Patientenzufriedenheit sowie eine signifikant bessere Wiederherstellung der
Sportfähigkeit als ein konservatives Vorgehen. Zudem konnten Vorteile für die akute gegenüber einer verzögerten operativen Versorgung beobachtet werden.Rupturen der distalen Hamstring-Sehnen stellen eine noch seltenere Verletzung als die der proximalen Hamstring-Sehnen dar. Dabei sind vor allem Verletzungen der distalen
M.-biceps-femoris- und M.-semimembranosus-Sehne von klinischer Relevanz. Die Ruptur der distalen M.-biceps-femoris-Sehne tritt vorwiegend im Rahmen von Multiligamentverletzungen des
Kniegelenks auf. Jedoch ist die Literatur betreffend Verletzungen der distalen Hamstring-Sehnen, insbesondere isolierter Sehnenrupturen, nur auf Fallserien und Fallbeschreibungen
limitiert.Dieser Artikel bietet einen umfassenden Überblick über die Therapie von proximalen und distalen Rupturen der Hamstring-Sehnen.
Verletzungen der proximalen Rectus-femoris- und Adductor-longus-Sehne
Authors: Kim Suchung , Lacheta Lucca , Stöckle Ulrich 
Published: July 2023

ZusammenfassungSehnenrupturen der proximalen Rectus-femoris- und Adduktorensehne sind in der breiten Bevölkerung zwar sehr selten, jedoch in Sportarten wie Fußball oder Sprinten aufgrund sportspezifischer und immer wiederkehrender Bewegungsabläufe häufiger und von großer Relevanz, da sie zu langen Ausfallzeiten bis hin zum Karriereende führen können.Anatomisch sind der 2-gelenkige (diarthrodiale) Verlauf des M. rectus femoris (RF) und der lange Verlauf des M. adductor longus (AL), vom oberen Schambeinast zum dorsalen Femur, charakteristisch. Durch schnelle, kraftvolle Hüftflexionsbewegungen und abrupte Adduktionsbewegungen bei schnellen Richtungswechseln in diversen Sportarten sind beide Muskeln häufig von Verletzungen betroffen.Die Anamnese und klinische Untersuchung sind meist wegweisend, eine anschließende bildgebende Diagnostik jedoch für beide Muskeln essenziell. Die Sonografie und die Magnetresonanztomografie (MRT) sind dabei der Goldstandard. Die Therapie kann sowohl konservativ als auch operativ durchgeführt werden und ist abhängig vom Schweregrad der Verletzung.Eine konservativ behandelte RF-Ruptur birgt die Gefahr von persistierenden Beschwerden und einem relevanten Kraftdefizit bei Wiederaufnahme der sportlichen Belastung, weshalb bei sportlich hohem Anspruch die Indikation zur operativen Refixation großzügiger gestellt werden sollte.Im Bereich der proximalen AL zeigt die operative Therapie nach derzeitigem Stand keinen Vorteil. Eine Besonderheit stellt der Apophysenabriss bei Kindern und Jugendlichen dar und bedarf nicht selten einer osteosynthetischen Versorgung.
Clinical Informatics Approaches to Facilitate Cancer Data Sharing
Authors: Aneja Sanjay , Avesta Arman , Xu Hua , Machado Lucila Ohno 
Published: July 2023

Objectives: Despite growing enthusiasm surrounding the utility of clinical informatics to improve cancer outcomes, data availability remains a persistent bottleneck to progress. Difficulty combining data with protected health information often limits our ability to aggregate larger more representative datasets for analysis. With the rise of machine learning techniques that require increasing amounts of clinical data, these barriers have magnified. Here, we review recent efforts within clinical informatics to address issues related to safely sharing cancer data.
Methods: We carried out a narrative review of clinical informatics studies related to sharing protected health data within cancer studies published from 2018-2022, with a focus on domains such as decentralized analytics, homomorphic encryption, and common data models.
Results: Clinical informatics studies that investigated cancer data sharing were identified. A particular focus of the search yielded studies on decentralized analytics, homomorphic encryption, and common data models. Decentralized analytics has been prototyped across genomic, imaging, and clinical data with the most advances in diagnostic image analysis. Homomorphic encryption was most often employed on genomic data and less on imaging and clinical data. Common data models primarily involve clinical data from the electronic health record. Although all methods have robust research, there are limited studies showing wide scale implementation.
Conclusions: Decentralized analytics, homomorphic encryption, and common data models represent promising solutions to improve cancer data sharing. Promising results thus far have been limited to smaller settings. Future studies should be focused on evaluating the scalability and efficacy of these methods across clinical settings of varying resources and expertise.
Obstructive Sleep Apnea in Adults with Treacher Collins Syndrome is Related with Altered Anthropometric Measurements, Increased Blood Pressure and Impaired Quality of Life
Authors: Vilma Fidélis-da Silva Leide , Henrique Kiemle-Trindade Sergio , Noel Marzano-Rodrigues Maria , Hollara Medeiros Laís , Tonello Cristiano , Kiemle Trindade-Suedam Ivy 
Published: July 2023

Abstract
Objectives This study aimed at evaluating the risk for obstructive sleep apnea (OSA) and its frequency in adults with Treacher Collins syndrome (TCS). The association of OSA with excessive daytime sleepiness (EDS), respiratory symptoms, and clinical variables was also assessed.
Material and Methods The subjects were prospectively screened for OSA through the Berlin Questionnaire and type I polysomnography. The Epworth Sleepiness Scale and the Respiratory Symptoms Questionnaire were used for assessing OSA-related symptoms. Quality of life was assessed by means of the Short Form 36 Health Survey.
Results The sample comprised 20 adults with TCS (55.0% female), aged 22.6 ± 5.8 years. Mean values of systemic blood pressure (113.0 ± 12.6/68.0 ± 9.5mmHg), body mass index (22.9 ± 5.9kg/m2), neck (34.1 ± 4.3cm), and waist circumference (80.4 ± 13.6cm) characterized the sample. A high risk for OSA was detected in 35% of the sample. Polysomnography results indicated an OSA frequency of 44.4%, with a median apnea-hypopnea index (AHI) value of 3.8 events/hour (minimum = 0.2; maximum = 77.5). Snoring (75.0%), nasal obstruction (70.0%) and EDS (20.0%) were the reported OSA-related symptoms. Quality of life median scores were 72.3 points (minimum = 45.0; maximum = 91.1). Strong positive correlations between AHI versus waist circumference and AHI versus systolic blood pressure were found. Moderate positive correlations between AHI versus body mass index and AHI versus neck circumference were detected. Negative correlation between AHI versus vitality were also observed.
Conclusion Adults with TCS are at high risk for OSA, which is associated with respiratory symptoms, altered anthropometric measurements, increased systolic pressure and impairment of quality of life.
Hybridisation rates, population structure, and dispersal of sambar deer (Cervus unicolor) and rusa deer (Cervus timorensis) in south-eastern Australia
Authors: Hill Erin , Murphy Nicholas , Li-Williams Scarlett , Davies Christopher , Forsyth David , Comte Sebastien , Rollins Lee Ann , Hogan Fiona , Wedrowicz Faye , Crittle Troy , Thomas Elaine , Woodford Luke , Pacioni Carlo 
Published: July 2023

Context Introduced populations of sambar deer (Cervus unicolor) and rusa deer (Cervus timorensis) are present across south-eastern Australia and are subject to local population control to alleviate their negative impacts. For management to be effective, identification of dispersal capability and management units is necessary. These species also readily hybridise, so additional investigation of hybridisation rates across their distributions is necessary to understand the interactions between the two species. Aims Measure the hybridisation rate of sambar and rusa deer, assess broad-scale population structure present within both species and identify distinct management units for future population control, and measure the likely dispersal capability of both species. Methods In total, 198 sambar deer, 189 rusa deer, and three suspected hybrid samples were collected across Victoria and New South Wales (NSW). After sequencing and filtering, 14 099 polymorphic single-nucleotide polymorphism (SNP) markers were retained for analysis. Hybridisation rates were assessed before the data were split by species to identify population structure, diversity indices, and dispersal distances. Key results Across the entire dataset, 17 hybrids were detected. Broad-scale population structure was evident in sambar deer, but not among the sites where rusa deer were sampled. Analysis of dispersal ability showed that a majority of deer movement occurred within 20 km in both species, suggesting limited dispersal. Conclusions Distinct management units of sambar deer can be identified from the dataset, allowing independent population control. Although broad-scale population structure was not evident in the rusa deer populations, dispersal limits identified suggest that rusa deer sites sampled in this study could be managed separately. Sambar × rusa deer hybrids are present in both Victoria and NSW and can be difficult to detect on the basis of morphology alone. Implications Genetic analysis can identify broad-scale management units necessary for population control, and estimates of dispersal capability can assist in delineating management units where broad-scale population structure may not be apparent. The negative impacts associated with hybridisation require further investigation to determine whether removal of hybrids should be considered a priority management aim.