bluuebunny/crossref_metadata_2025_split huggingface dataset:
Censored density forecasts: Production and evaluation
Authors: Mitchell James , Weale Martin 
Published: February 2023

SummaryThis paper develops methods for the production and evaluation of censored density forecasts. The focus is on censored density forecasts that quantify forecast risks in a middle region of the density covering a specified probability and ignore the magnitude but not the frequency of outlying observations. We propose a fixed‐point algorithm that fits a potentially skewed and fat‐tailed density to the inner observations, acknowledging that the outlying observations may be drawn from a different but unknown distribution. We also introduce a new test for calibration of censored density forecasts. An application using historical forecast errors from the Federal Reserve Board and the Monetary Policy Committee (MPC) at the Bank of England suggests that the use of censored density functions to represent the pattern of forecast errors results in much greater parameter stability than do uncensored densities. We illustrate the utility of censored density forecasts when quantifying forecast risks after shocks such as the global financial crisis and the COVID‐19 pandemic and find that these outperform the official forecasts produced by the MPC.
Comparison of wet and dried chickpea yeast in breadmaking
Authors: Durmaz Raziye , Şahin Nazlı , Koyuncu Mehmet , Sayaslan Abdulvahit 
Published: February 2023

AbstractBACKGROUNDChickpea yeast (CY), initiated by spontaneous fermentation of coarsely‐ground chickpea in water, is considered a variant of conventional sourdough and contributes somewhat similarly to bakery products. As the preparation of wet CY prior to each baking process poses certain difficulties, its usage in dry form has been gaining interest. In this study, CY was used either directly in freshly prepared wet form or in freeze‐dried and spray‐dried forms at 50, 100 and 150 g kg−1 levels (all on 14% moisture basis) in substitution with wheat flour to compare their effects on bread properties.RESULTSUtilization of all forms of CY did not noticeably change the contents of protein, fat, ash, total carbohydrate and damaged starch in the wheat flour–CY mixtures. However, falling numbers and sedimentation volumes of CY‐containing mixtures decreased significantly, due probably to the increase in the amylolytic and proteolytic activities during chickpea fermentation. These changes somewhat corresponded to improved dough processability. Both wet and dried CY samples reduced pH levels of doughs and breads, and increased probiotic lactic acid bacteria (LAB) count. Total phenolic contents, antioxidant capacities and flavor scores of CY‐containing breads were significantly enhanced. However, CY usage slightly influenced yield, moisture content, volume, color and hardness values of breads.CONCLUSIONEffects of wet and dried forms of CY on bread properties were quite comparable, indicating that CY can be used upon properly drying similarly to the conventional wet form.© 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Novel IRF6 variant in orofacial cleft patients from Durban, South Africa
Authors: Naicker Thirona , Alade Azeez , Adeleke Chinyere , Mossey Peter A. , Awotoye Waheed A. , Busch Tamara , Li Mary , Olotu Joy , Aldous Colleen , Butali Azeez 
Published: February 2023

AbstractBackgroundTo date, there are over 320 variants identified in the IRF6 gene that cause Van der Woude syndrome or popliteal pterygium syndrome. We sequenced this gene in a South African orofacial cleft cohort to identify the causal IRF6 variants in our population.MethodSaliva samples from 100 patients with syndromic and non‐syndromic CL ± P were collected. Patients were recruited from the cleft clinics at two public, tertiary hospitals in Durban, South Africa (SA), namely Inkosi Albert Luthuli Central Hospital (IALCH) and KwaZulu‐Natal Children's Hospital (KZNCH). We prospectively sequenced the exons of IRF6 in 100 orofacial cleft cases, and where possible, we also sequenced the parents of the individuals to determine the segregation pattern.ResultsTwo variants were identified; one novel (p.Cys114Tyr) and one known (p.Arg84His) missense variant in IRF6 gene were identified. The patient with the p.Cys114Tyr variant was non‐syndromic with no clinical VWS phenotype expected of individuals with IRF6 coding variants, and the patient with the p.Arg84His had phenotypic features of popliteal pterygium syndrome. The p.Arg84His variant segregated in the family, with the father also being affected.ConclusionsThis study provides evidence that IRF6 variants are found in the South African population. Genetic counselling is essential for affected families, particularly in the absence of a known clinical phenotype since it helps with the plans for future pregnancies.
Comparing male and female pelvic floor muscle function by the number and type of pelvic floor symptoms
Authors: Notenboom‐Nas Françoise J. M. , Knol‐de Vries Grietje E. , Slieker‐ten Hove Marijke C. P. , Dekker Janny H. , Keuken Debby G. , van Koeveringe Gommert A. , Blanker Marco H. 
Published: February 2023

AbstractAimsPelvic floor symptoms (PFS), including lower urinary tract symptoms, defecation problems, sexual dysfunction, and pelvic pain, are common in males and females. Comparing pelvic floor musculature (PFM) function between sexes may reveal important differences relevant to clinical care. This study aimed to compare male and female PFM function and to assess the function of both sexes with the number and type of PFS.MethodsWe purposively enrolled males and females aged ≥ 21 years with 0–4 PFS based on questionnaire responses in an observational cohort study. Participants then underwent PFM assessment, and muscle function in the external anal sphincter (EAS) and puborectal muscle (PRM) were compared between sexes. The relationships between muscle function and the number and type of PFS were explored.ResultsOf the invited 400 males and 608 females, 199 and 187 underwent PFM assessment, respectively. Compared with females, males more often showed increased EAS and PRM tone during assessments. Compared with males, females more often showed weaker maximum voluntary contraction (MVC) of the EAS and dysfunctional endurance of both muscles; additionally, those with zero or one PFS, sexual dysfunction, and pelvic pain more often showed a weak MVC of the PRM.ConclusionsDespite a few similarities between males and, females we found differences in muscle tone, MVC, and endurance between male and female PFM function. These findings provide useful insights into the differences in PFM function between males and females.
Improved a priori error estimates for a discontinuous Galerkin pressure correction scheme for the Navier–Stokes equations
Authors: Masri Rami , Liu Chen , Riviere Beatrice 
Published: February 2023

AbstractThe pressure correction scheme is combined with interior penalty discontinuous Galerkin method to solve the time‐dependent Navier–Stokes equations. Optimal error estimates are derived for the velocity in the L2 norm in time and in space. Error bounds for the discrete time derivative of the velocity and for the pressure are also established. The analysis is challenging and technical and is based on appropriate use of lift operators and duality arguments.
Tin Bromido Aluminate Networks with Bright Luminescence
Authors: Wolf Silke , Köppe Ralf , Roesky Peter W. , Feldmann Claus 
Published: February 2023

AbstractThe novel tin bromido aluminates [Sn3(AlBr4)6](Al2Br6) (1), Sn(AlBr4)2 (2), [EMIm][Sn(AlBr4)3] (3) and [BMPyr][Sn(AlBr4)3] (4) ([EMIm]: 1‐ethyl‐3‐methylimidazolium, [BMPyr]: 1‐butyl‐1‐methyl‐pyrrolidinium), are obtained from a ionic‐liquid‐based reaction of AlBr3 and SnCl2 or SnBr2, resulting in colorless and transparent crystals. 1 contains a neutral, inorganic ∞3[Sn3(AlBr4)6] network filled with intercalated Al2Br6 molecules. 2 represents a 3D structure isotypic to Pb(AlCl4)2 or α‐Sr[GaCl4]2. 3 and 4 exhibit infinite ∞1[Sn(AlBr4)3]n− chains that are separated by the voluminous [EMIm]+/[BMPyr]+ cations. All title compounds contain Sn2+ coordinated by AlBr4 tetrahedra, resulting in chains or 3D networks. Moreover, all title compounds show photoluminescence due to Br−→Al3+ ligand‐to‐metal charge‐transfer excitation, followed by 5s2p0←5s1p1 emission on Sn2+. Most surprisingly, the luminescence is highly efficient (quantum yield >50 %). Specifically, 3 and 4 exhibit outstanding quantum yields of 98 and 99 %, which are the highest values observed for Sn2+‐based luminescence so far. The title compounds have been characterized by single‐crystal structure analysis, elemental analysis, energy‐dispersive X‐ray analysis, thermogravimetry, infrared and Raman spectroscopy, UV‐Vis and photoluminescence spectroscopy.
Thermoelectric properties of polyvinylpyrrolidone/polyaniline‐mixed Bi2Te3 composites prepared by electrospinning
Authors: Khan Jan Sher , Akram Rizwan , Hussain Mozaffar , Rafique Saima , Kayani Farrukh Bashir , Rehman Anis ur 
Published: February 2023

AbstractComposite fibers of bismuth telluride (Bi2Te3) with polyaniline (PANI) and polyvinylpyrrolidone (PVP), synthesized via electrospinning in different ratios, were studied. Initially, three solutions were synthesized in different ratios of PVP and composite (Bi2Te3 and PANI). However, due to the loading capacity of polymer only two samples were successfully synthesized. The formation and surface morphology of as‐prepared and compacted fibers were studied by scanning electron microscopy. The X‐ray diffraction confirmed the increase in crystalline phase of the composites after compaction. The influence of functional groups on the thermal and electrical conductivity as well as the existence of various polymer functional groups in pure and composite samples were revealed by Fourier transform infrared spectroscopy. Thermogravimetric analysis and differential scanning calorimetric were carried out simultaneously up to 800 K, which revealed the thermal stability of composite up‐to 473 K and a glass transition temperature (Tg) of ~412 K for the composites. Diffuse reflectance spectroscopy confirmed the decrease in the bandgap from ~3 to ~1.2 eV of the compacted fibers. The thermopower of the as‐prepared and compacted fibers increased significantly compared with pure Bi2Te3 and PANI, while the thermal conductivity decreased to 0.45 Wm−1 K−1. As a result, zT was enhanced from 1.7 × 10−10 to 1.7 × 10−1 in the composite samples near room temperature.
hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen‐induced transcriptional response in prostate cancer
Authors: Adams Mark N. , Croft Laura V. , Urquhart Aaron , Saleem Mohamed Ashick Mohamed , Rockstroh Anja , Duijf Pascal H. G. , Thomas Patrick B. , Ferguson Genevieve P. , Najib Idris Mohd , Shah Esha T. , Bolderson Emma , Nagaraj Shivashankar , Williams Elizabeth D. , Nelson Colleen C. , O'Byrne Kenneth J. , Richard Derek J. 
Published: February 2023

AbstractBackgroundActivation and regulation of androgen receptor (AR) signaling and the DNA damage response impact the prostate cancer (PCa) treatment modalities of androgen deprivation therapy (ADT) and radiotherapy. Here, we have evaluated a role for human single‐strand binding protein 1 (hSSB1/NABP2) in modulation of the cellular response to androgens and ionizing radiation (IR). hSSB1 has defined roles in transcription and maintenance of genome stability, yet little is known about this protein in PCa.MethodsWe correlated hSSB1 with measures of genomic instability across available PCa cases from The Cancer Genome Atlas (TCGA). Microarray and subsequent pathway and transcription factor enrichment analysis were performed on LNCaP and DU145 prostate cancer cells.ResultsOur data demonstrate that hSSB1 expression in PCa correlates with measures of genomic instability including multigene signatures and genomic scars that are reflective of defects in the repair of DNA double‐strand breaks via homologous recombination. In response to IR‐induced DNA damage, we demonstrate that hSSB1 regulates cellular pathways that control cell cycle progression and the associated checkpoints. In keeping with a role for hSSB1 in transcription, our analysis revealed that hSSB1 negatively modulates p53 and RNA polymerase II transcription in PCa. Of relevance to PCa pathology, our findings highlight a transcriptional role for hSSB1 in regulating the androgen response. We identified that AR function is predicted to be impacted by hSSB1 depletion, whereby this protein is required to modulate AR gene activity in PCa.ConclusionsOur findings point to a key role for hSSB1 in mediating the cellular response to androgen and DNA damage via modulation of transcription. Exploiting hSSB1 in PCa might yield benefits as a strategy to ensure a durable response to ADT and/or radiotherapy and improved patient outcomes.
Pros and cons for statins use and risk of Parkinson's disease: An updated perspective
Authors: Al‐kuraishy Hayder M. , Al‐Gareeb Ali I. , Alexiou Athanasios , Papadakis Marios , Alsayegh Abdulrahman A. , Almohmadi Najlaa Hamed , Saad Hebatallah M. , Batiha Gaber El‐Saber 
Published: February 2023

AbstractParkinson's disease (PD) is the second most frequent neurodegenerative brain disease (NBD) after Alzheimer's disease (AD). Statins are the most common lipid‐lowering agents used in the management of dyslipidemia and the prevention of primary and secondary cardiovascular diseases (CVD) events. In addition, there is a controversial point regarding the role of serum lipids in the pathogenesis of PD. In this bargain, as statins reduce serum cholesterol so they affect the PD neuropathology in bidirectional ways either protective or harmful. Statins are not used in the management of PD, but they are frequently used in the cardiovascular disorders commonly associated with PD in the elderly population. Therefore, the use of statins in that population may affect PD outcomes. Concerning the potential role of statins on PD neuropathology, there are conflicts and controversies either protective against the development of PD or harmful by increasing the risk for the development of PD. Therefore, this review aimed to clarify the precise role of statins in PD regarding the pros and cons from published studies. Many studies suggest a protective role of statins against PD risk through the modulation of inflammatory and lysosomal signaling pathways. Nevertheless, other observations suggest that statin therapy may increase PD risk by diverse mechanisms including reduction of CoQ10. In conclusion, there are strong controversies regarding the protective role of statins in PD neuropathology. Therefore, retrospective and prospective studies are necessary in this regard.
Factors influencing short‐term parasitoid establishment and efficacy for the biological control ofHalyomorpha halyswith the samurai waspTrissolcus japonicus
Authors: Falagiarda Martina , Carnio Veronica , Chiesa Serena Giorgia , Pignalosa Antonio , Anfora Gianfranco , Angeli Gino , Ioriatti Claudio , Mazzoni Valerio , Schmidt Silvia , Zapponi Livia 
Published: February 2023

AbstractBACKGROUNDClassical biological control has been identified as the most promising approach to limit the impact of the invasive pest speciesHalyomorpha halys(Heteroptera: Pentatomidae). This study investigated the parasitism rate at sites where the biocontrol agentTrissolcus japonicus(Hymenoptera: Scelionidae) was released and where its unintentional introduction took place, in the Trentino–South Tyrol region. The effect of land‐use composition was studied to understand which factors favor the establishment of hosts and parasitoids, including native and exotic species.RESULTSThe releasedT. japonicuswere detected a year after the start of the program, with a significant parasitoid impact and discovery, compared to control sites.Trissolcus japonicuswas the most abundantH. halysparasitoid, andTrissolcus mitsukuriiandAnastatus bifasciatuswere recorded also. The efficacy ofT. mitsukuriiwas lower in sites whereT. japonicuswas successfully established, suggesting a possible competitive interaction. Parasitism level byT. japonicusat the release sites was 12.5% in 2020 and 16.4% in 2021. The combined effect of predation and parasitization increasedH. halysmortality up to 50% at the release sites. Landscape composition analysis showed that bothH. halysandT. japonicuswere more likely to be found at sites with lower altitude and with permanent crops, whereas other hosts and parasitoids preferred different conditions.CONCLUSIONTrissolcus japonicusshowed a promising impact onH. halys, at release and adventive sites, with minor nontarget effects, mediated by landscape heterogeneity. The prevalence ofT. japonicusin landscapes with permanent crops could support IPM in the future. © 2023 The Authors.Pest Management Sciencepublished by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Resection of a colloid adenocarcinoma of the lung: A case report
Authors: Kogita Yuya , Ose Naoko , Kawagishi Kotaro , Morii Eiichi , Shintani Yasushi 
Published: February 2023

AbstractColloid adenocarcinoma of the lung is a rare subtype of lung adenocarcinoma, accounting for only about 0.24% of lung cancers. Because of its rarity, long‐term postoperative prognostic reports are limited. In this report, we describe a case of colloid adenocarcinoma of the lung with a 5‐year recurrence‐free follow‐up. The patient is a 66‐year‐old woman. During postoperative follow‐up for ovarian cancer, chest CT showed a 45 × 30 mm sized mass in the left lung with mixed low‐absorption areas inside that were suspicious of cystic lesion. We suspected metastatic lung tumour, and performed lower lobectomy. Pathological examination revealed pale tumour cells forming a glandular lumen with internal mucus production. Based on the results of immunostaining we diagnosed colloid adenocarcinoma of the lung. She received postoperative adjuvant chemotherapy and is alive 4 years postoperatively without recurrence. Colloid adenocarcinoma of the lung, even if large, may have a good prognosis if completely resected.
Diagnostic performance of hepatitis C core antigen assay to identify active infections: A systematic review and meta‐analysis
Authors: Sepúlveda‐Crespo Daniel , Treviño‐Nakoura Ana , Bellón José M. , Fernández‐Rodríguez Amanda , Ryan Pablo , Martínez Isidoro , Jiménez‐Sousa María A. , Resino Salvador 
Published: February 2023

AbstractHepatitis C virus (HCV) core antigen (HCVcAg) assay is an alternative for diagnosing HCV infection in a single step. This meta‐analysis aimed to evaluate the Abbott ARCHITECT HCV Ag assay's diagnostic performance (validity and utility) for diagnosing active hepatitis C. PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library were searched until 10 January 2023. The protocol was registered at the prospective international register of systematic reviews (PROSPERO: CRD42022337191). Abbott ARCHITECT HCV Ag assay was the test for evaluation, and nucleic acid amplification tests with a cut‐off ≤50 IU/mL were the gold standard. Statistical analysis was performed using STATA with the MIDAS module and random‐effects models. The bivariate analysis was conducted on 46 studies (18,116 samples). The pooled sensitivity was 0.96 (95% CI = 0.94–0.97), specificity 0.99 (95% CI = 0.99–1.00), positive likelihood ratio 141.81 (95% CI = 72.39–277.79), and negative likelihood ratio 0.04 (95% CI = 0.03–0.06). The area under the summary receiver operating characteristic curve was 1.00 (95% CI = 0.34–1.00). For active hepatitis C prevalence values of 0.1%–15%, the probability that a positive test was a true positive was 12%–96%, respectively, indicating that a confirmatory test should be necessary, particularly with a prevalence ≤5%. However, the probability that a negative test was a false negative was close to zero, indicating the absence of HCV infection. The validity (accuracy) of the Abbott ARCHITECT HCV Ag assay for screening active HCV infection in serum/plasma samples was excellent. Although the HCVcAg assay showed limited diagnostic utility in low prevalence settings (≤1%), it might help diagnose hepatitis C in high prevalence scenarios (≥5%).
Hydrogels: From Design to Applications in Forensic Investigations
Authors: Sandhu Anuradha , Bhatia Tejasvi 
Published: February 2023

AbstractThe concept of green hydrogels in forensics is a budding area where it encompasses the concept of sustainable investigation. Motivated by the need to prepare for the next generation advanced materials for implementing proactive forensic science strategy. The work conception, already successful in a few fields, aimed at implementing the sophisticated criminal's way of thinking, predicting their next move so that the crime‐fighting authorities can be one step ahead of them and take precautionary actions. The existing problems of current society need to be solved by deliberate efforts of researchers and forensic experts, as we can formulate strategy of design, production, and characterization of innovative polymeric materials for on spot detection of traces. Various innovative materials have been explored with the help of green chemistry. Fingerprinted products that are unique in their compilation are made in forensics by utilizing the concept of green chemistry. The creation of nontoxic hydrogels by utilizing green polymers that are biodegradable, biocompatible, and bio renewable is one such field that helps in forensic applications. The distinctive properties of hydrogels make them suitable for various forensic investigations. In this review article, we have focused on the unique sparked properties of these smart gels and opened a gateway in solving various unsolved mysteries.
Synthesis and Characterization of Polydopamine‐Modified Montmorillonite Loaded with Silver Nanoparticles for Antibacterial Functionalization
Authors: Wang Huiyan , Huang Xinrong , Liang Han , Sun Xuemei , Meng Na , Zhou Ninglin 
Published: February 2023

AbstractSince the development of bacterial resistance towards antibiotics has the potential to limit the effectiveness of antibiotics in the treatment of infectious diseases, it is necessary to try different strategies to provide alternatives. In order to solve the problems, this work used silver nanoparticles‐loaded polydopamine‐modified montmorillonite (AgNP/PDA−Mt) to cope with the infection of the gram‐negative bacteria Escherichia. Coli and the gram‐positive bacteria Staphylococcus. aureus. Polydopamine‐modified montmorillonite (PDA−Mt) was used to reduce silver ions into silver nanoparticles through the hydroxyl groups of polydopamine. The chemical properties and morphology of AgNP/PDA−Mt were analyzed by X‐ray diffraction spectroscopy (XRD), fourier transform infrared spectroscopy (FT‐IR), transmission electron microscope (TEM), scanning electron microscope (SEM), etc. Also, its antimicrobial property has been investigated. The results showed that AgNP/PDA−Mt possessed significant sterilization at low doses. And the results had been shown its acceptable biocompatibility.