bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma-induced interconnected networks in microporous activated carbons from palm petiole under NaNO3 oxidizing environment towards high-performance electric double layer capacitors (EDLCs)
Authors: Benwannamas Nurulsafeelanaria , Sangtawesin Tanagorn , Yilmaz Murat , Kanjana Kotchaphan 
Published: August 2023

AbstractActivated carbons (ACs) were developed from palm petiole via a new eco-friendly method composed of highly diluted H2SO4 hydrothermal carbonization and low-concentration KOH-activating pyrolysis followed by gamma-induced surface modification under NaNO3 oxidizing environment. The prepared graphitic carbons were subsequently used as an active material for supercapacitor electrodes. The physiochemical properties of the ACs were characterized using field emission scanning electron microscope–energy dispersive X-ray spectroscopy, N2 adsorption/desorption isotherms with Brunauer–Emmett–Teller surface area analysis, Fourier transform infrared spectroscopy, X-ray diffraction and Raman spectroscopy. The electrochemical performance of the fabricated electrodes was investigated by cyclic voltammetry, galvanostatic charge–discharge and electrochemical impedance spectroscopy. Even treated with extremely low H2SO4 concentration and small KOH:hydrochar ratio, the maximum SBET of 1365 m2 g−1 for an AC was obtained after gamma irradiation. This was attributed to radiation-induced interconnected network formation generating micropores within the material structure. The supercapacitor electrodes exhibited electric double-layer capacitance giving the highest specific capacitance of 309 F g−1 as well as excellent cycle stability within 10,000 cycles. The promising results strongly ensure high possibility of the eco-friendly method application in supercapacitor material production.
Coherently driven quantum features using a linear optics-based polarization-basis control
Authors: Ham Byoung S. 
Published: August 2023

AbstractQuantum entanglement generation is generally known to be impossible by any classical means. According to Poisson statistics, coherent photons are not considered quantum particles due to the bunching phenomenon. Recently, a coherence approach has been applied for quantum correlations such as the Hong–Ou–Mandel (HOM) effect, Franson-type nonlocal correlation, and delayed-choice quantum eraser to understand the mysterious quantum features. In the coherence approach, the quantum correlation has been now understood as a direct result of selective measurements between product bases of phase-coherent photons. Especially in the HOM interpretation, it has been understood that a fixed sum-phase relation between paired photons is the bedrock of quantum entanglement. Here, a coherently excited HOM model is proposed, analyzed, and discussed for the fundamental physics of two-photon correlation using linear optics-based polarization-basis control. For this, polarization-frequency correlation in a Mach–Zehnder interferometer is coherently excited using synchronized acousto-optic modulators, where polarization-basis control is conducted via a selective measurement process of the heterodyne signals. Like quantum operator-based destructive interference in the HOM theory, a perfectly coherent analysis shows the same HOM effects of the paired coherent photons on a beam splitter, whereas individual output intensities are uniform.
Deciphering the molecular basis of abiotic stress response in cucumber (Cucumis sativus L.) using RNA-Seq meta-analysis, systems biology, and machine learning approaches
Authors: Zinati Zahra , Nazari Leyla 
Published: August 2023

AbstractAbiotic stress in cucumber (Cucumis sativus L.) may trigger distinct transcriptome responses, resulting in significant yield loss. More insight into the molecular underpinnings of the stress response can be gained by combining RNA-Seq meta-analysis with systems biology and machine learning. This can help pinpoint possible targets for engineering abiotic tolerance by revealing functional modules and key genes essential for the stress response. Therefore, to investigate the regulatory mechanism and key genes, a combination of these approaches was utilized in cucumber subjected to various abiotic stresses. Three significant abiotic stress-related modules were identified by gene co-expression network analysis (WGCNA). Three hub genes (RPL18, δ-COP, and EXLA2), ten transcription factors (TFs), one transcription regulator, and 12 protein kinases (PKs) were introduced as key genes. The results suggest that the identified PKs probably govern the coordination of cellular responses to abiotic stress in cucumber. Moreover, the C2H2 TF family may play a significant role in cucumber response to abiotic stress. Several C2H2 TF target stress-related genes were identified through co-expression and promoter analyses. Evaluation of the key identified genes using Random Forest, with an area under the curve of ROC (AUC) of 0.974 and an accuracy rate of 88.5%, demonstrates their prominent contributions in the cucumber response to abiotic stresses. These findings provide novel insights into the regulatory mechanism underlying abiotic stress response in cucumber and pave the way for cucumber genetic engineering toward improving tolerance ability under abiotic stress.
A machine learning approach for thermodynamic modeling of the statically measured solubility of nilotinib hydrochloride monohydrate (anti-cancer drug) in supercritical CO2
Authors: Nateghi Hassan , Sodeifian Gholamhossein , Razmimanesh Fariba , Mohebbi Najm Abad Javad 
Published: August 2023

AbstractNilotinib hydrochloride monohydrate (NHM) is an anti-cancer drug whose solubility was statically determined in supercritical carbon dioxide (SC-CO2) for the first time at various temperatures (308–338 K) and pressures (120–270 bar). The mole fraction of the drug dissolved in SC-CO2ranged from 0.1 × 10–5to 0.59 × 10–5, corresponding to the solubility range of 0.016–0.094 g/L. Four sets of models were employed to evaluate the correlation of experimental data; (1) ten empirical and semi-empirical models with three to six adjustable parameters, such as Chrastil, Bartle, Sparks, Sodeifian, Mendez-Santiago and Teja (MST), Bian, Jouyban, Garlapati-Madras, Gordillo, and Jafari-Nejad; (2) Peng-Robinson equation of state (Van der Waals mixing rule, had anAARD%of 10.73); (3) expanded liquid theory (modified Wilson model, on average, theAARDof this model was 11.28%); and (4) machine learning (ML) algorithms (random forest, decision trees, multilayer perceptron, and deep neural network with respective R2values of 0.9933, 0.9799, 0.9724 and 0.9701). All the models showed an acceptable agreement with the experimental data, among them, the Bian model exhibited excellent performance with anAARD%of 8.11. Finally, the vaporization (73.49 kJ/mol) and solvation (− 21.14 kJ/mol) enthalpies were also calculated for the first time.
Cross-species transcriptomics reveals bifurcation point during the arterial-to-hemogenic transition
Authors: Mo Shaokang , Qu Kengyuan , Huang Junfeng , Li Qiwei , Zhang Wenqing , Yen Kuangyu 
Published: August 2023

AbstractHemogenic endothelium (HE) with hematopoietic stem cell (HSC)-forming potential emerge from specialized arterial endothelial cells (AECs) undergoing the endothelial-to-hematopoietic transition (EHT) in the aorta-gonad-mesonephros (AGM) region. Characterization of this AECs subpopulation and whether this phenomenon is conserved across species remains unclear. Here we introduce HomologySeeker, a cross-species method that leverages refined mouse information to explore under-studied human EHT. Utilizing single-cell transcriptomic ensembles of EHT, HomologySeeker reveals a parallel developmental relationship between these two species, with minimal pre-HSC signals observed in human cells. The pre-HE stage contains a conserved bifurcation point between the two species, where cells progress towards HE or late AECs. By harnessing human spatial transcriptomics, we identify ligand modules that contribute to the bifurcation choice and validate CXCL12 in promoting hemogenic choice using a human in vitro differentiation system. Our findings advance human arterial-to-hemogenic transition understanding and offer valuable insights for manipulating HSC generation using in vitro models.
Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer
Authors: Schmidt Daniel R. , Gramatikov Iva Monique T. , Sheen Allison , Williams Christopher L. , Hurwitz Martina , Dodge Laura E. , Holupka Edward , Kiger W. S. , Cornwall-Brady Milton R. , Huang Wei , Mak Howard H. , Cormier Kathleen S , Condon Charlene , Dane Wittrup K. , Yilmaz Ömer H. , Stevenson Mary Ann , Down Julian D. , Floyd Scott R. , Roper Jatin , Vander Heiden Matthew G. 
Published: August 2023

Abstract
Background
Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to multimodality therapy used in patients. Radiation therapy (RT) is frequently used to treat localized cancers with curative intent, delay progression of oligometastases, and palliate symptoms of metastatic disease.

Methods
Here we report the development, testing, and validation of a platform to immobilize and target tumors in mice with stereotactic ablative RT (SART). Xenograft and autochthonous tumor models were treated with hypofractionated ablative doses of radiotherapy.

Results
We demonstrate that hypofractionated regimens used in clinical practice can be effectively delivered in mouse models. SART alters tumor stroma and the immune environment, improves survival in GEMMs of primary prostate and colorectal cancer, and synergizes with androgen deprivation in prostate cancer. Complete pathologic responses were achieved in xenograft models, but not in GEMMs.

Conclusions
While SART is capable of fully ablating xenografts, it is unable to completely eradicate disease in GEMMs, arguing that resistance to potentially curative therapy can be modeled in GEMMs.
Efficient tensor model‐Toeplitz matrix iterative reconstruction for angle estimation with nested array
Authors: Zhan Chenghong , Hu Guoping , Zhao Fangzheng , Zhou Hao 
Published: August 2023

AbstractThis letter proposes an efficient tensor model for Direction of Departure (DOD) and Direction of Arrival (DOA) estimation based on bistatic nested Multiple‐Input Multiple‐Output (MIMO) radar. Tensor offers a robust solution in characterizing multi‐dimensional data structures, ensuring data integrity, and has demonstrated remarkable effectiveness in the realm of multi‐dimensional parameter estimation. However, the complexity of traditional methods for constructing tensors is a major obstacle to practical applications. In response, this research introduces a novel approach that utilizes an iterative two‐dimensional Toeplitz matrix reconstruction method to rapidly derive expanded virtual covariance matrices prior to tensor construction. This streamlines the algorithm and improves efficiency. Numerical simulations have verified the superiority of this algorithm.
Improved direct current electrical properties of XLPE modified by graftable antioxidant and crosslinking coagent at a wide temperature range
Authors: Yang Xu , Zhao Hong , Zhang Chengcheng , Li Chunyang , Zhao Xindong , Yang Jiaming , Wang Xuan 
Published: August 2023

AbstractTo enhance the DC electrical performance of cross‐linked polyethylene (XLPE), the graftable antioxidant methacrylic acid 2‐hydroxy‐3‐(4‐anilinoanilino) propyl ester (GA), which contains carbonyl and amino groups, and the crosslinking coagent trimethylolpropane trimethacrylate (TMPTMA), which contains carbonyl groups, are individually or co‐grafted onto XLPE. The slightly higher deep trap density introduced by higher grafting concentration of TMPTMA results in more significant suppression effect of conductance current and enhanced breakdown strength at a lower temperature, while the suppression effect for the conductance current at 90°C becomes weakened due to limited trap energy. Meanwhile, the deeper energy level introduced by GA suppresses the conductance current and improves the electrical strength of XLPE at 90°C more significantly. By co‐grafting, the conductance current of XLPE in a wide range temperature can be significantly reduced, especially for the temperature dependence of conductance current, which is beneficial to suppress the field strength reversal. The results of thermally stimulated current and molecular simulation show that the polar groups of two monomers introduce deep charge traps in XLPE. The co‐grafting system ensures the rationality of the crosslinking reaction kinetics and does not affect the cable manufacturing.
Non‐contact and anti‐interference diagnosis of SiC MOSFET module bond wire faults for EV wireless charging device
Authors: Ma Mingyao , Wang Ning , Wang Hanyu , Guo Weisheng , Wang Hai 
Published: August 2023

AbstractSiC MOSFET modules are widely used for bidirectional wireless charging of electric vehicles. However, prolonged use can result in bond wire faults, leading to reliability issues. To address this problem, a non‐contact bond wire monitoring method that can be carried out using the charging coil of the wireless charging device is proposed. Here, two monitoring loops are constructed based on the circuit topology, and their impedance magnitudes are measured on the charging coil to avoid the influence of battery voltage on monitoring results. To detect the bond wire condition, the impedance magnitude difference of the two monitoring loops is chosen as an indicator, which is very sensitive to the bond wire lift‐off. However, the monitoring results may be influenced by the aging of resonant capacitors and the offset of the charging coil. In particular, the influence of the coil offset is significant. To mitigate this effect, a prognostic parameter calibration method is proposed. Experimental results confirm the effectiveness of the proposed method, which provides a promising solution for the reliable and safe operation of SiC MOSFET modules in wireless charging devices.
Peculiarities of the underflooding process in cohesive soils
Authors: Gryaznova Elena 
Published: August 2023

The article deals with the peculiarities of underflooding of basements of buildings erected in cohesive soils. Conducted research has shown that a feature of these soils is the possibility of formation in them sporadically developed aquifer with a very low filtration coefficient. For this reason, this horizon is not always recorded during the survey and, accordingly, is rarely taken into account in the design. In order to save money, the construction is usually limited to waterproofing the basement walls and using loose material as backfill soils inthecavityslots.
Thus, in the backfilled excavation slots, a medium capable of accumulating water is formed. With thegradualfilling of this container, under the conditions of the impossibility of water drainage into the foundation mass, due to the small filtration coefficient and the creation of appropriate pressure gradients, as well as possible defects in waterproofing, there are stable leaks in the basements of buildings ready for operation.
The article analyzes the occurrence of such situations in a number of examples of erected buildings. The main sources of water ingress into the backfilled cavities of the excavation are indicated and a number of practical recommendations are given to avoid the occurrence of such situations in the future.
Strahlentherapie und Herz
Authors: Seuthe Katharina , Pfister Roman 
Published: August 2023

ZusammenfassungDie Strahlentherapie ist weiterhin ein wichtiger Bestandteil der modernen Tumortherapie. Als strahlentherapieassoziierte, kardiovaskuläre Komplikationen können sowohl kurzfristig, vor allem
aber viele Jahre nach Ende der Therapie eine koronare Herzerkrankung, eine Herzinsuffizienz, eine Pericarditis constrictiva oder eine Herzklappenerkrankung auftreten. Beschrieben ist dies
besonders für Patienten mit Hodgkin-Lymphom, Bronchialkarzinom und linksseitigem Mammakarzinom wegen der meist thorakalen und damit herznahen Bestrahlung.Ein besonders hohes Risiko für Toxizität besteht bei Patienten mit zusätzlicher Gabe von Anthrazyklinen, hohen Strahlendosen (> 25 Gy Mean Heart Dose, MHD), Krebserkrankung in
Kindesalter sowie mehreren zusätzlichen kardiovaskulären Risikofaktoren. Insbesondere diese Patienten sollten langfristig kardiologisch nachuntersucht werden. Hierzu gehört die
transthorakale Echokardiografie (mindestens alle 5 Jahre) und die nicht invasive Koronardiagnostik (alle 5–10 Jahre).
Immuntherapien: Was muss der Kardiologe wissen?
Authors: Totzeck Matthias 
Published: August 2023

ZusammenfassungZu den wichtigsten Immuntherapeutika in der Onkologie zählen die Immun-Checkpoint-Inhibitoren (ICI). ICI konnten die Prognose verschiedener Krebsarten signifikant verbessern. Im Gegensatz
zu konventionellen Therapien üben ICI Antitumorwirkungen aus, indem sie das körpereigene Immunsystem aktivieren, welches dann wiederum Krebszellen aktiv eliminieren kann. Es gibt 3
zugelassene ICI-Klassen: Inhibitoren, die auf das zytotoxische T-Lymphozyten-assoziierte Antigen 4 (CTLA4), den programmierten Tod 1/den programmierten Todesliganden 1 (PD1/PDL1) und das
Lymphozytenaktivierungsgen 3 (LAG3) abzielen. ICI sind häufig mit unterschiedlichen Toxizitäten verbunden, die als immunvermittelte unerwünschte Ereignisse bekannt sind (engl. Immune-related
Adverse Events, irAE). Akute kardiovaskuläre immunvermittelte Nebenwirkungen wie z. B. die Myokarditis sind selten, können aber fatale Folgen für Lebensqualität und das Überleben haben,
sodass eine frühzeitige Diagnose und Therapie entscheidend sind.
Kardiovaskuläre Überwachung und Primärprävention bei Krebstherapien
Authors: Seoudy Hatim , Frank Derk , Müller Oliver 
Published: August 2023

ZusammenfassungFortschritte bei der Behandlung von Krebserkrankungen haben zu einer erheblichen Verbesserung der Prognose und einer zunehmenden Bedeutung kardiotoxischer Nebenwirkungen infolge einer
onkologischen Therapie geführt. In diesem Zusammenhang hat sich die Kardioonkologie als neue Subspezialisierung etabliert. Die Kardioonkologie verfolgt das Ziel, die Prävention und
Behandlung kardiovaskulärer Erkrankungen bei Krebspatienten zu verbessern. Die erstmals im Jahre 2022 publizierten ESC-Leitlinien zum Thema Kardioonkologie beinhalten umfassende Empfehlungen
zur kardiovaskulären Risikostratifizierung, Überwachung, Diagnose und Primärprävention im Kontext onkologischer Erkrankungen und Therapien.
Asymmetric Allenylation of N-Acylhydrazones with Propargyltrichlorosilane Catalyzed by Helical Chiral 2,2′-Bipyridine N-Monoxide
Authors: Takenaka Norito , Xu Changgong , Nader Phillip , Xavier Jonathan 
Published: August 2023

Abstract(M)-Helicene-derived 2,2′-bipyridine N-monoxide catalyzed the allenylation of N-acylhydrazones with propargyltrichlorosilane with excellent regioselectivity and moderate-to-good enantioselectivity. This study represents the first catalytic asymmetric allenylation of acylhydrazones.
Synthesis of Novel C
2 Bishydroxamic Acid Ligands and their Application in Asymmetric Epoxidation Reactions
Authors: Olivares-Romero José L. , Pawar Tushar Janardan , Valtierra-Galvan Marco F. , Rodríguez-Hernández Alfredo , Reyes-Luna Alfonso , Bonilla-Landa Israel , García-Barradas Oscar , Barrera-Méndez Felipe 
Published: August 2023

AbstractAsymmetric oxidation reactions have significantly benefited from bishydroxamic Brønsted acid ligands, and they can proceed with remarkable stereoselectivity. Designing and synthesizing these ligands are essential for achieving high enantioselectivity in metal-catalyzed oxidation reactions. This paper presents a straightforward method for synthesizing novel phenyl-ring-centric bishydroxamic acids (BHA). A preliminary analysis of Ti-BHA-catalyzed reactions resulted in asymmetric epoxides with an exceptional enantiomeric excess (>99% ee). At the same time, ongoing experiments aim to improve the reaction conversion for enhanced overall efficiency.
Cervicovaginal Microbial–Immune State and Group B Streptococcus Colonization in Pregnancy
Authors: McCoy Jennifer A. , Burris Heather H. , Gerson Kristin D. , McCarthy Clare , Ravel Jacques , Elovitz Michal A. 
Published: August 2023

Objective Maternal colonization with Group B Streptococcus (GBS) is a significant risk factor for serious neonatal morbidity. There are limited data on how the cervicovaginal (CV) microbiota and host immune factor β-defensin-2 might influence GBS colonization in pregnant individuals. This study sought to determine if the CV microbiota is associated with GBS colonization in pregnant individuals, and if β-defensin-2 modifies this relationship.
Study Design This was a secondary analysis of a prospective cohort study of pregnant individuals with singleton pregnancies who had CV microbiota specimens analyzed at 16 to 20, 20 to 24, and 24 to 28 weeks' gestation, along with a third trimester GBS rectovaginal (RV) culture (n = 492). Microbiota data were analyzed with 16S rRNA gene sequencing and classified into community state types (CSTs). Log-binomial multivariable regression was used to model associations between CST and GBS RV status and to calculate risk ratios. β-defensin-2, an immune factor known to modulate the relationship between CST and pregnancy outcomes, was examined as an effect modifier.
Results Of 492 individuals, 34.3% were GBS RV + . Compared with individuals with CST I at 16 to 20 weeks, individuals with CST IV-A and CST II had a significantly elevated relative risk of subsequent GBS RV+ status. When stratified by high and low β-defensin-2 levels, β-defensin-2 was found to be an effect modifier of the association between CST IV-A and GBS RV+ status. In individuals with low β-defensin-2 levels, CST VI-A was associated with GBS RV+ status, but among individuals with high β-defensin-2 levels, there was no such association (interaction p-value = 0.03).
Conclusion Pregnant individuals with CV microbiota characterized by CST IV-A and CST II had significantly elevated risk of GBS RV colonization in the third trimester compared with those with CST I, and β-defensin-2 was an effect modifier of the association between CST IV-A and GBS RV+ status. Future research should investigate if manipulation of the CV microbiota can prevent GBS colonization, thereby reducing intrapartum antibiotic prophylaxis and the risks of neonatal GBS infection.
Key Points
The coexistence of nationalism, Westernization, Russification, and Russophobia: facets of parallelization in the Russian invasion of Ukraine
Authors: Boman Björn 
Published: August 2023

AbstractParallelization theory complements earlier concepts in cultural and political history by focusing on the coexistence of seemingly contradictory patterns in various localities, such as segregation/integration of migrants in Europe and the USA, polarization/hybridization in Korea and Ukraine, and secularization/the resurgence of religions in countries like Malaysia and Sweden. The current article examines the parallel presence of Ukrainian nationalism/Westernization and Russification/Russophobia before and in the aftermath of the 2022 Russian invasion of Ukraine. The argument is bolstered by both Russian, Ukrainian, and Western media sources, showing how and why these seemingly conflicting tendencies coexist.