bluuebunny/crossref_metadata_2025_split huggingface dataset:
Six months follow up of hemodialysis patients after SARS-CoV-2 vaccinations: Effects of the booster dose and vaccine t
Authors: MURT Ahmet , ALTİPARMAK Mehmet Riza , DİNC Harika Oyku , YALİN Serkan Feyyaz , MESE Meral , YADİGAR Serap , YİLDİZ Zeynep , KOCAZEYBEK Bekir , PEKPAK Meltem , ATAMAN Muveddet Rezzan 
Published: June 2023

Background: As hemodialysis patients are among the vulnerable groups for severe COVID-19, proper vaccination of these patients is quite important. However vaccine responsiveness is generally reduced in hemodialysis patients and strategies should be developed to maintain protection in the long term.
Objectives: This study aimed to analyse the changes in antibody levels of SARS-CoV-2 vaccinated hemodialysis patients after six months and to compare the effectiveness of inactivated and mRNA vaccines.
Methods: Eighty-five hemodialysis patients were followed up for six months after their initial vaccinations for SARS-CoV-2. Persistence of humoral responses were compared between patients who got inactivated or mRNA vaccines and also between patients who received a booster dose and those who didn’t. SARS-CoV-2 antibody titers were measured by a commercial test that measures IgG antibodies toward the receptor-binding domain of spike protein.
Results: Seropositivity that was achieved by initial vaccination dropped abruptly by 6 months. Patients who received a booster dose had significantly higher antibody levels than those who didn’t (1120,8 ± 983,3 AU/mL vs 313,3 ± 435,3 AU/mL respectively; p
Akromegali hastalarında Growth hormon ve insülin like growth faktör-1 düzeyi ile aterosklerotik risk belirteçleri arasındaki ilişki
Authors: BODAKÇİ Erdal , KILINÇ Faruk , TUNA Mazhar Müslüm , TUZCU Alpaslan Kemal , PEKKOLAY Zafer , KARABULUT Aziz 
Published: June 2023

Amaç: Akromegali hastalarında büyüme hormonu (BH) ve insülin benzeri büyüme faktörü- 1(IGF-1) düzeyi ile hastalık süresi ile aktif ve remisyonda bulunan hastaların epikardiyal yağ kalınlığı ve karotis intima-media kalınlığı arasındaki ilişkiyi araştırmayı amaçladık.
Yöntemler: Bu çalışmaya 40 akromegalik hasta (23 kadın, 17 erkek) ve 40 kontrol grubu (23 kadın, 17 erkek) dahil edildi. Hastaların kilo, boy, vücut kitle indeksi, bel çevresi, sistolik ve diastolik kan basınçları, lipid paneli, insülin, glukoz, üre, kreatinin, BH, IGF-1 düzeyi ölçüldü ve tam kan sayımı yapıldı. Ekokardiyografik olarak epikardiyal yağ kalınlığı ve doppler ultrasonografi ile karotis intima-media kalınlığına bakıldı.
Bulgular: Hastaların yaş ortalaması 39.5 ± 10.1, kontrol grubunun yaş ortalaması 39.3 ± 10.1 yıldı. Tüm hastaların BH ve IGF-1 düzeyi kontrol grubundan yüksekti(p
Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer
Authors: Wolff Antonio C. , Somerfield Mark R. , Dowsett Mitchell , Hammond M. Elizabeth H. , Hayes Daniel F. , McShane Lisa M. , Saphner Thomas J. , Spears Patricia A. , Allison Kimberly H. 
Published: June 2023

Purpose.—
To update the American Society of Clinical Oncology–College of American Pathologists (ASCO-CAP) recommendations for human epidermal growth factor receptor 2 (HER2) testing in breast cancer. An Update Panel is aware that a new generation of antibody-drug conjugates targeting the HER2 protein is active against breast cancers that lack protein overexpression or gene amplification.

Methods.—
The Update Panel conducted a systematic literature review to identify signals for updating recommendations.

Results.—
The search identified 173 abstracts. Of 5 potential publications reviewed, none constituted a signal for revising existing recommendations.

Recommendations.—
The 2018 ASCO-CAP recommendations for HER2 testing are affirmed.

Discussion.—
HER2 testing guidelines have focused on identifying HER2 protein overexpression or gene amplification in breast cancer to identify patients for therapies that disrupt HER2 signaling. This update acknowledges a new indication for trastuzumab deruxtecan when HER2 is not overexpressed or amplified but is immunohistochemistry (IHC) 1+ or 2+ without amplification by in situ hybridization. Clinical trial data on tumors that tested IHC 0 are limited (excluded from DESTINY-Breast04), and evidence is lacking that these cancers behave differently or do not respond similarly to newer HER2 antibody-drug conjugates. Although current data do not support a new IHC 0 versus 1+ prognostic or predictive threshold for response to trastuzumab deruxtecan, this threshold is now relevant because of the trial entry criteria that supported its new regulatory approval. Therefore, although it is premature to create new result categories of HER2 expression (eg, HER2-Low, HER2-Ultra-Low), best practices to distinguish IHC 0 from 1+ are now clinically relevant. This update affirms prior HER2 reporting recommendations and offers a new HER2 testing reporting comment to highlight the current relevance of IHC 0 versus 1+ results and best practice recommendations to distinguish these often subtle differences. Additional information is available at www.asco.org/breast-cancer-guidelines.
La contribución del bosque amazónico a las condiciones de vida de la población rural de la Reserva de Biosfera Sumaco, Ecuador
Authors: Torres Navarrete Segundo Bolier , Vallejo Luis , Cedeño Juan Pablo , Torres Navarrete Yenny , Gómez Aníbal 
Published: June 2023

Los recursos del bosque son importantes para el bienestar de millones de familias en países en desarrollo. Sin embargo, evaluar las condiciones de vida rurales y la dependencia del bosque es complejo, especialmente cuando se debe colectar datos de áreas cultivadas y no cultivadas tomando bienes de bosques naturales y ríos para consumo o venta. Para examinar la contribución del ecosistema bosque a las condiciones de vida de las poblaciones Kichwa y Mestizas del centro-norte de la Amazonía ecuatoriana, se usó una base de datos que fue colectada a través de 680 encuestas dirigidas a 170 hogares de manera trimestral durante un año en 32 comunidades en las zonas de amortiguamiento y transición de la Reserva de Biosfera Sumaco. Los resultados muestran que existe un disparidad entre Mestizos y Kichwa no sólo en los rubros de ingresos económicos, sino en las actividades que se comportan como principal fuente de ingreso. Para los hogares Kichwa existe mayor diversidad de fuentes de ingresos proveniente de la finca, mientras que para los hogares Mestizos existe una dependencia marcada de la ganadería como principal fuente de ingreso.
NCCN Virtual Policy Summit: Defining the “New Normal” — 2021 and the State of Cancer Care in America Following 2020
Authors: Schatz Alyssa A. , Bandini Lindsey , Carlson Robert W. 
Published: June 2023

Abstract
US healthcare systems have been deeply impacted by significant societal shifts over the past several years. The COVID-19 pandemic has changed the way we interact with healthcare, political narratives have impacted how healthcare is perceived and engaged with by the public, and the United States has become increasingly aware of historic and ongoing racial injustices across all health and social systems. The watershed events experienced during the last several years play a critical role in shaping the future of cancer care for payers, providers, manufacturers, and, most importantly, patients and survivors. To explore these issues, in June 2021 NCCN convened a virtual policy summit: Defining the “New Normal” — 2021 and the State of Cancer Care in America Following 2020. This summit offered the opportunity for a varied group of stakeholders to begin to explore the impact of recent events on the current and future state of oncology in the United States. Topics included the impact of COVID-19 on cancer detection and treatment, the role of innovation in ensuring continuity of care, and efforts to create more equitable systems of care.
Fertilizer and herbicide alter nectar and pollen quality with consequences for pollinator floral choices
Authors: Russo Laura , Ruedenauer Fabian , Gronert Angela , Van de Vreken Isabelle , Vanderplanck Maryse , Michez Denis , Klein Alexandra , Leonhardt Sara , Stout Jane C. 
Published: June 2023

Background
Pollinating insects provide economically and ecologically valuable services, but are threatened by a variety of anthropogenic changes. The availability and quality of floral resources may be affected by anthropogenic land use. For example, flower-visiting insects in agroecosystems rely on weeds on field edges for foraging resources, but these weeds are often exposed to agrochemicals that may compromise the quality of their floral resources.

Methods
We conducted complementary field and greenhouse experiments to evaluate the: (1) effect of low concentrations of agrochemical exposure on nectar and pollen quality and (2) relationship between floral resource quality and insect visitation. We applied the same agrochemcial treatments (low concentrations of fertilizer, low concentrations of herbicide, a combination of both, and a control of just water) to seven plant species in the field and greenhouse. We collected data on floral visitation by insects in the field experiment for two field seasons and collected pollen and nectar from focal plants in the greenhouse to avoid interfering with insect visitation in the field.

Results
We found pollen amino acid concentrations were lower in plants exposed to low concentrations of herbicide, and pollen fatty acid concentrations were lower in plants exposed to low concentrations of fertilizer, while nectar amino acids were higher in plants exposed to low concentrations of either fertilizer or herbicide. Exposure to low fertilizer concentrations also increased the quantity of pollen and nectar produced per flower. The responses of plants exposed to the experimental treatments in the greenhouse helped explain insect visitation in the field study. The insect visitation rate correlated with nectar amino acids, pollen amino acids, and pollen fatty acids. An interaction between pollen protein and floral display suggested pollen amino acid concentrations drove insect preference among plant species when floral display sizes were large. We show that floral resource quality is sensitive to agrochemical exposure and that flower-visiting insects are sensitive to variation in floral resource quality.
Diversity of wetland zooplankton in the Lachlan River catchment, New South Wales, Australia
Authors: Kobayashi Tsuyoshi , Miller Jan , Shiel Russell J. , Segers Hendrik , Hunter Simon J. 
Published: June 2023

ABSTRACT
Inland wetlands are areas of high biodiversity, providing various ecosystem services. In this study, we assessed the species diversity of wetland zooplankton in the Lachlan River catchment. Biodiversity sampling is labour-intensive and attained sample size is often not large enough to detect all species present. Therefore, we applied integrated rarefaction and extrapolation sampling curves and asymptotic analysis to estimate species richness. We observed 103 species of rotifers, 29 species of cladocerans and 13 species of copepods, with further 14 rotifers, three cladocerans and four copepods identified at higher than species level, totalling 117 taxa of rotifers, 32 taxa of cladocerans and 17 taxa of copepods from 36 wetland sites across the catchment. The observed zooplankton species included the first record of the rotifer Trochosphaera solstitialis in Australia, and the first record of the rotifers Brachionus lyratus tasmaniensis, Keratella shieli, Lepadella tyleri, Notholca salina and N. squamula and the cladoceran Alona setuloides in NSW. Based on the integrated sampling curves and asymptotic analysis of species richness in wetlands of the Lachlan River catchment, greater additions of rotifers (estimated asymptote: ≈ 145) are more likely to be realised with increasing sample size than those of cladocerans (estimated asymptote: ≈ 36) and copepods (estimated asymptote: ≈ 18).
Safety Profile of Methotrexate in Patients with Rheumatoid Arthritis
Authors: Kabara Abhishek L. , Patil Pournima S. , Mohan Prashanth B. 
Published: June 2023

Background: Methotrexate (MTX) is recommended as first-line therapy in patients with active Rheumatoid Arthritis (RA) as monotherapy or in combination with other disease-modifying anti-rheumatic drugs (DMARDs). Despite being considered a safe drug, some toxicities of MTX are inevitable and patients discontinue further treatment with MTX for the same.
Objective: To evaluate the safety profile of Methotrexate in patients with RA.
Methodology: An observational cross sectional study was conducted at a tertiary care hospital from 1st January 2020 to 31st December 2020 at rheumatology OPD in department of medicine, KLES, Dr. Prabhakar Kore Hospital, Belagavi. 117 patients diagnosed with RA who had been undergoing methotrexate treatment for at least six months as monotherapy or in combination with other DMARDs were included. Patient demographics, disease and treatment characteristics, side effects, and blood and laboratory markers specific to RA were studied with regards to methotrexate. Continuous variables were presented as mean and standard deviation, while categorical variables were presented as frequency and percentage. Association between categorical variables was done using Fisher exact test and chi square test.
Results: The study predominantly consisted of females (85.5%), and the mean age of patients was 47.92±13.398 years. Patient-reported side effects were seen/observed in 47% of patients. Commonly reported minor side effects were fatigue (17.1%), nausea (16.2%), anorexia (11.1%), stomatitis/oral ulcers (10.3%), epigastric burning (8.5%), hair fall (3.4%), and vomiting in 0.9% of patients. Demographic and clinical factors were not associated with side effects. There was no significant association between side effects and type of treatment.
Conclusion: Use of methotrexate in combination with other DMARDs is safe and should be encouraged as first line treatment of RA on routine basis. However, periodic blood and laboratory monitoring along with patient follow-ups are essential for early detection of toxicities.
Some Womanist Inscriptions in Ebony Reigns’ Song Maame Hwɛ: A Literary Approach
Authors: Yeboah Philomena Ama Okyeso , Sanka Confidence Gbolo , Bonku Lucy Korkoi 
Published: June 2023

Music is a part of life in Ghana. Studying a people’s music brings one closer to understanding them since music and reality are intertwined. Despite this reality, the contribution of popular music to national discourse has not received adequate research attention in Ghana. This paper sets out to study the lyrics of one of the songs of Ebony Reigns (Opoku-Kwarteng Priscilla), a Ghanaian musician who died few years ago. Using the womanist theory, the paper investigates how the tenets of this theory are inscribed in the song, the problems that womanism addresses in the song and their implications to the Ghanaian youth. The researchers conclude from the analysis in the paper that the youth have to use social media with caution; they need to listen to advice from the elderly in choosing life partners and the African woman needs to fight for self-expression and liberation through positive cultural means.
Suppressing the Photoinduced Halide Segregation in Wide‐Bandgap Perovskite Solar Cells by Strain Relaxation
Authors: Liu Hui , Dong Jing , Wang Pengyang , Shi Biao , Zhao Ying , Zhang Xiaodan 
Published: June 2023

AbstractEfficient and stable wide bandgap (WBG) perovskite solar cells (PSCs) are imperative for fabricating superior tandem devices. However, small crystal grains and light‐induced phase segregation of WBG perovskite result in large open‐circuit voltage (VOC) deficits, critically impeding the development of the related devices. Herein, the effective functional groups of Lewis‐base trans‐Ferulic acid (t‐FA) are employed to release the residual microstrain in the perovskite lattice. Larger perovskite crystals are formed by strengthening the interaction between the perovskite solute and solution. The lattice structure is stabilized to suppress light‐induced halide segregation. Finally, the power conversion efficiency (PCE) of the optimized device with a bandgap of ≈1.77 eV is increased from 17.33% to 19.31% with the enhancement of VOC. Moreover, replacing a mixture of MeO‐2PACZ and Me‐4PACZ as the hole transporting layer (HTL), the PCE further lifts to 19.9% and VOC is 1.32 V, one of the highest performances reported for WBG PSCs, especially for devices prepared entirely by solution spin‐coating. Therefore, this study provides a practicable alternative for realizing efficient WBG PSCs, which can contribute to the growth of perovskite‐based tandem devices.
Thermoelectric and Photoelectric Dual Modulated Sensors for Human Internet of Things Application in Accurate Fire Recognition and Warning
Authors: Li Gang , Hu Yue , Chen Jihao , Liang Lirong , Liu Zhuoxin , Fu Jia , Du Chunyu , Chen Guangming 
Published: June 2023

AbstractThe emergence of the Internet of Things (IoT) era has necessitated the development of intelligent wearable electronics for fire warning to mitigate fire hazards prior to ignition. Although significant advancements are achieved in thermoelectric materials and devices, the design of a specific thermoelectric wearable device for precision fire warning still remains challenging. In this study, an intelligent sensing system for human IoT fire warning that utilizes a novel light/heat dual‐parameter‐responsive single‐walled carbon nanotube/poly(3‐hexylthiophene‐2,5‐diyl) (SWCNT/P3HT) composite is developed. This system comprises the composite, a circuit microcontroller, and a message transmission system, which together create an intelligent fire source sensing device. The synergistic effect of light and heat is observed to enhance the output voltage and response time under concurrent stimuli, as compared to heating alone. The intelligent sensing system is found to effectively identify and alarm for fire sources, owing to the high thermoelectric and photoelectric performance of the SWCNT/P3HT composite, precise fire recognition, and the ability to adjust the alarming threshold for detecting fire hazards. This study presents a new approach for designing light/heat dual‐parameter‐responsive materials and wearable devices, which hold potential applications in smart home living environments, including child protection against fire hazards.
Ion Irradiation Activated Catalytic Activity of MoSe2 Nanosheet for High‐Efficiency Hydrogen Evolution Reaction
Authors: Huang Liqiu , Wei Guo , Wang Jiaqi , Li Derun , Jia Shuangfeng , Wu Shixin , Jiang Tao , Guo Yakun , Liu Yichao , Ren Feng 
Published: June 2023

AbstractDeveloping highly efficient, low cost, and stable electrocatalysts that work at a large current density is crucial for upgrading the current industrial electrochemical water splitting to produce H2. Molybdenum selenide (MoSe2) is a promising 2D transition metal dichalcogenide (TMD), however, its reported output is inadequate due to its inert basal plane. Herein, the catalytic activity of MoSe2 nanosheet arrays is activated by a novel and controllable method of He+ ion irradiation to introduce multiple vacancies simultaneously into their inert basal planes. The vacancies activated MoSe2 have improved electrocatalytic performance and stability with a minimum overpotential of 90 mV at 10 mA cm−2, a Tafel slope of 49 mV dec−1 and high stability of 650 h at the industry‐level large current density of 1000 mA cm−2 compared to several hours for the pristine sample. The DFT results reveal that single Se and single Mo vacancies on the MoSe2 basal plane can efficiently increase the electrical conductivity and reduce energy barriers for water dissociation and subsequent proton adsorption, thus improving the electrocatalytic capability. This finding proves the application of ion beam in defect engineering for effective hydrogen evolution in TMDs‐based catalysts.
Biofloc technology as part of a sustainable aquaculture system: A review on the status and innovations for its expansion
Authors: McCusker Stephen , Warberg Majbritt Bolton , Davies Simon J. , Valente Cecilia de Souza , Johnson Mark P. , Cooney Ronan , Wan Alex H. L. 
Published: June 2023

AbstractIncreased food demand, reflecting a rising global human population, attaining 8 billion in 2022, has furthered the intensification of farmed aquatic animal production. Intensification practices can be resource demanding for micro and macronutrients, dedicated feeds, fossil fuels, chemotherapeutics, and water. Water replaces evaporative losses and may be used to dilute nutrient‐rich wastewater. As an alternative to wastewater discharge, biofloc technology (BFT) uses microbes to manage nutrient levels in production systems. A microbial community grown at high densities can assimilate waste metabolites for growth. This is promoted by increasing the carbon–nitrogen (C:N) ratio using a combination of aquafeed fed to the fish and an additional carbohydrate source, for example, starch, molasses, or bran. The microbial biomass offers a continuous and additional food source to the farmed animal, thus reducing the need for finished aquafeeds and lowering the feed conversion ratio. Although the approach relies on multiple interacting species, BFT can be deployed in relatively low technology settings. This review considers the basis of BFT and identifies areas for innovation and expansion. For example, control of light quantity and quality can influence the biofloc and hence the growth of cultured species. Research on biofloc aquaculture is dominated by studies using tilapia and shrimp, but the technology could be applied to other species, particularly species that are tolerant of biofloc conditions and not highly carnivorous. Biofloc may be a useful biosecurity tool for all or part of the life cycle, and meals made from dried biofloc may enhance the production of cultured species. The key benefits of BFT can potentially be seen in reduced water consumption, lower feed requirements, and improved fish health. This review differs from current review papers in proposing the use of a life cycle assessment in conjunction with BFT, which may be a useful tool for describing and communicating the relative benefits of biofloc systems and their wider environmental impact. This study will serve as a useful knowledge base of BFT information for students, researchers, and stakeholders alike, offering a central source of the main aspects around the culturing of biofloc, key parameters, common species used, areas of potential improvement, and a discussion on where the future of BFT may lie.
Light‐absorbing copolymers of polyimides as efficient photothermal materials for solar water evaporation
Authors: Li Shi‐Qin , Deng Yuan , Huang Jiang , Wang Pu , Liu Guoliang , Xie He‐Lou 
Published: June 2023

AbstractPolyimide (PI), an important engineering polymer with a rigid chemical structure, readily has excellent chemical stability, heat resistance, and electrical insulation but lacks broadband photothermal properties. Herein, we design and synthesize PI copolymers that embrace intrinsic photothermal properties by using two diamine monomers of (Z)‐2,3‐bis(4‐aminophenyl) acrylonitrile (CNDA) and 4,4‐diphenyldiamine (NDA) with strong ultraviolet (UV), and near‐infrared (NIR) absorption capabilities, respectively. Tuning the molar ratio of the two diamines can modulate UV and NIR light absorption and regulate the intrinsic photothermal properties of PIs. After condensation with pyromellitic dianhydride, the resulting PI‐0.5 with a unit molar ratio of CNDA:NDA = 1 shows the best photothermal efficiency. PI‐0.5 is used to construct 3D steam generators with vertically dried channels by a freeze‐drying method. The 3D steam generators show a good water evaporation rate and continuously operate with excellent stability under varying salinity and pH conditions. The synthetic design herein suggests that PI can be molecularly engineered to be intrinsic photothermal materials, expanding the properties and applications of existing PIs.