bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcification is a risk factor for intracranial in-stent restenosis: an optical coherence tomography study
Authors: Li Tianhua , Xu Ran , Ma Yan , Wang Tao , Yang Bin , Jiao Liqun 
Published: August 2023

BackgroundThe frequent occurrence of calcification in intracranial artery stenosis increases the risk of ischemic stroke. In previous cases, we have observed a possible relationship between calcification and intracranial in-stent restenosis (ISR) using optical coherence tomography (OCT). Therefore, our study aimed to demonstrate the relationship between intracranial calcification and ISR with a larger sample size.MethodsFor our study patients who underwent OCT for intracranial artery stenosis before stenting were included from May 2020 to October 2022. Follow-up assessments were performed using transcranial color-coded duplex (TCCD) sonography ultrasonography to detect cases of ISR.ResultsWe recruited 54 patients, 15 of them were excluded as they did not meet the study criteria. Our study included 39 patients, of whom 21 had calcification, and 18 did not. The results of our study revealed a significant association between calcification and intracranial ISR (9 (42.86) vs 2 (11.11), p=0.0375). Notably, patients with macrocalcification were more likely to undergo ISR than patients with spotty calcification (77.78% vs 22.22%, p=0.03).ConclusionOCT imaging demonstrates that calcification is an essential risk factor for intracranial ISR. These findings have important implications for individualized treatment. They provide valuable insights for optimizing stent design and exploring potential mechanisms of intracranial ISR.Trial registration numberClinicalTrials.gov Identifier:NCT05550077.
Early postpartum treatment strategies and early postpartum relapses in women with active multiple sclerosis
Authors: Haben Sabrina , Ciplea Andrea I , Tokic Marianne , Timmesfeld Nina , Thiel Sandra , Gold Ralf , Langer-Gould Annette Magdalene , Hellwig Kerstin 
Published: August 2023

BackgroundRelapse risk after delivery is increased in women with active multiple sclerosis (MS), the best strategy to reduce it is unknown. We aimed to assess the association of four different postpartum strategies with relapses during the first 6 months post partum.MethodsThis cohort study includes data prospectively collected through structured telephone interviews from the German Multiple Sclerosis and Pregnancy Registry. Pregnancies with active MS (fingolimod or natalizumab treatment OR relapse within 1 year before pregnancy) and postpartum follow-up of ≥6 months were included. We compared four strategies: (1) intention to breastfeed exclusively without disease-modifying therapy (DMT) (exclusive breast feeding ≥2 months or switching to non-exclusive/weaning within 2 weeks after a relapse during the first 2 months), (2) early treatment with natalizumab/fingolimod and (3) other DMT initiated within 6 weeks post partum before a relapse. If women did not or only partially breastfed, or started DMT≤6 weeks after delivery after a relapse or later, we assumed (4) no-DMT-no-exclusive- breastfeeding-strategy. Main outcome was time to postpartum MS relapses.ResultsIn 867 women with 911 pregnancies, most (n=416) intended to breastfeed exclusively or had no-DMT-no-exclusive-breastfeeding-strategy (n=290); fewer started fingolimod (n=38), natalizumab (n=74) or another DMT (n=93) early. Recurrent time-to-event analysis showed a statistically significant reduction in relapse hazard only with the natalizumab/fingolimod-strategy as of months 3–4 post partum compared with intention-to-breastfeed-exclusively-strategy. The very early relapse risk was highest in no-DMT-no-exclusive-breastfeeding-strategy.ConclusionIn active MS, an early postpartum treatment strategy should be determined well before delivery. Natalizumab/fingolimod-strategy reduced postpartum relapse hazard from month 3, but none diminished the early postpartum relapse hazard.
Vital role of clinicians in reducing the NHS carbon footprint through smarter procurement decisions
Authors: Al-Hadithy Nada , Knight Katie , Gopfert Anya , Van Hove Maria , Villa Garcia Xana 
Published: August 2023

BackgroundThe NHS’ impact on the environment is significant, accounting for 5.9% of the national carbon footprint of the UK and 20 million tonnes of carbon dioxide equivalent (Mt CO2e) emissions a year.The procurement of goods and services is responsible for 72% of the NHS carbon footprint—equivalent to 15.2Mt CO2e. Procurement is, therefore, a priority focus area to consider, if carbon reductions are to be made. The impact of procurement decisions extends over the ‘whole life’—from identification of the need for a product or service through to the provision of the product or service and including the product’s ‘end of life’ process (disposal).From April this year, any new procurement needs to have a 10% net zero and social value weighting. From April 2023 onward, any new procurement two times per day should incorporate carbon footprint and environmental impact.This paper aims to introduce clinicians to the concept of green procurement and illustrate the potential greenhouse gases savings possible if procurement decisions were informed by the sustainability credentials such as the carbon footprint of a product or the corporate social responsibility programme of the supplier.MethodsWhile seconded at the Department of Health and Social Care, the senior author on this paper collaborated with the NHS Supply Chain to pilot carbon footprinting of one clinical item. We chose to focus on the 20-gauge ‘pink’ cannula as a high-volume familiar article; 25 million cannulas are purchased via the NHS Supply Chain each year, of which the most commonly used size is the 20 gauge.ResultsOf the seven companies approached, five sent us their CSR strategies. Four companies provided product primary data, and of these four, one provided sufficient data to carry out a carbon footprint analysis. The one set of detailed data provided was for two 20-gauge cannulas, 1 with wings and 1 without. The total carbon footprint for Cannula 1 is 33.92 g CO2e. The total carbon footprint for Cannula 2 is 35.45 g CO2e. This amounts to a 1.54 g CO2e difference between the 2 cannulas.ConclusionIt is both necessary and possible for the NHS to demonstrate leadership in reducing the carbon footprint of healthcare.We have provided an overview of NHS procurement to empower clinicians to get involved with local and national decision-making. We have demonstrated the potential carbon savings that could be made through careful choice of products. We have also highlighted the risks if clinicians do not engage with green procurement.
Fatigue in patients with rheumatic and musculoskeletal diseases: a scoping review on definitions, measurement instruments, determinants, consequences and interventions
Authors: Beckers Esther , Hermans Kasper , Van Tubergen Astrid , Boonen Annelies 
Published: August 2023

ObjectivesTo scope published reviews addressing fatigue in rheumatoid arthritis (RA), spondyloarthritis, osteoarthritis and fibromyalgia in areas relevant for clinical practice: (1) definition, (2) measurement instruments and diagnosis, (3) determinants, (4) consequences and (5) effectiveness of interventions.MethodsA systematic literature search of reviews was performed in five bibliographical databases. A hierarchical data extraction was applied based on review type (Cochrane reviews (CRs), followed by non-Cochrane systematic reviews (SRs) and narrative reviews (NRs)) and year of publication. Extracted data were summarised in elaborated narrative syntheses. Results were discussed with a patient panel.ResultsOne hundred and thirty-four reviews were included (19 CRs, 44 SRs, 71 NRs). No agreed on definition was reported for general fatigue, nor for types of fatigue. Twenty-five measurement instruments were found, all self-reported. Five instruments proposed a threshold for excessive fatigue. Pain, physical function and depressive symptoms were the most frequently studied disease-related determinants of fatigue; female sex and stress the most frequent contextual determinants. Work performance, followed by impact on pain, physical activity and social roles were the most frequently studied consequences. Whenever quantified, associations between fatigue with determinants and consequences were on average small. For non-pharmacological interventions, if effect sizes were reported, these were negligible to small and for pharmacological interventions negligible to moderate. Patients recommended actions for research and practice.ConclusionSyntheses of reviews point to the complexity of fatigue. The extensive amount of evidence could be used to offer tailored management plans to patients in clinical practice and inform future research agendas.
The human brain connectome weighted by the myelin content and total intra-axonal cross-sectional area of white matter tracts
Authors: Nelson Mark C. , Royer Jessica , Lu Wen Da , Leppert Ilana R. , Campbell Jennifer S. W. , Schiavi Simona , Jin Hyerang , Tavakol Shahin , Vos de Wael Reinder , Rodriguez-Cruces Raul , Pike G. Bruce , Bernhardt Boris C. , Daducci Alessandro , Misic Bratislav , Tardif Christine L. 
Published: August 2023

Abstract
A central goal in neuroscience is the development of a comprehensive mapping between structural and functional brain features, which facilitates mechanistic interpretation of brain function. However, the interpretability of structure-function brain models remains limited by a lack of biological detail. Here, we characterize human structural brain networks weighted by multiple white matter microstructural features including total intra-axonal cross-sectional area and myelin content. We report edge-weight-dependent spatial distributions, variance, small-worldness, rich club, hubs, as well as relationships with function, edge length, and myelin. Contrasting networks weighted by the total intra-axonal cross-sectional area and myelin content of white matter tracts, we find opposite relationships with functional connectivity, an edge-length-independent inverse relationship with each other, and the lack of a canonical rich club in myelin-weighted networks. When controlling for edge length, networks weighted by either fractional anisotropy, radial diffusivity, or neurite density show no relationship with whole-brain functional connectivity. We conclude that the co-utilization of structural networks weighted by total intra-axonal cross-sectional area and myelin content could improve our understanding of the mechanisms mediating the structure-function brain relationship.
Localizing Syntactic Composition with Left-Corner Recurrent Neural Network Grammars
Authors: Sugimoto Yushi , Yoshida Ryo , Jeong Hyeonjeong , Koizumi Masatoshi , Brennan Jonathan R. , Oseki Yohei 
Published: August 2023

Abstract
In computational neurolinguistics, it has been demonstrated that hierarchical models such as recurrent neural network grammars (RNNGs), which jointly generate word sequences and their syntactic structures via the syntactic composition, better explained human brain activity than sequential models such as long short-term memory networks (LSTMs). However, the vanilla RNNG has employed the top-down parsing strategy, which has been pointed out in the psycholinguistics literature as suboptimal especially for head-final/left-branching languages, and alternatively the left-corner parsing strategy has been proposed as the psychologically plausible parsing strategy. In this article, building on this line of inquiry, we investigate not only whether hierarchical models like RNNGs better explain human brain activity than sequential models like LSTMs, but also which parsing strategy is more neurobiologically plausible, by developing a novel fMRI corpus where participants read newspaper articles in a head-final/left-branching language, namely Japanese, through the naturalistic fMRI experiment. The results revealed that left-corner RNNGs outperformed both LSTMs and top-down RNNGs in the left inferior frontal and temporal-parietal regions, suggesting that there are certain brain regions that localize the syntactic composition with the left-corner parsing strategy.
A Corpus of Illuminated Qurʾāns from Coastal East Africa
Authors: Hirji Zulfikar 
Published: August 2023

Abstract
This article examines a little-known corpus of illuminated Qurʾān manuscripts that were produced between ca. 1750–ca. 1850 in the Swahili city-states of Pate, Siyu, and Faza on Pate Island in the Lamu archipelago (Kenya). Now dispersed in collections in Kenya, Tanzania, Oman, the UK, and the USA, the manuscripts have many distinctive features: decorative frontispieces, sūra titles, basmalas, and division and prostration markers; locally developed Arabic script styles; colophons containing names of copyists and completion dates; endowment dedications; northern Italian-made paper; and, blind-stamped, leather covers. The list of known manuscripts presented in the appendix is aimed at encouraging the identification, digitization, and study of other manuscripts in the corpus. The study of their content, materiality, and contexts of production can advance scholarship on the histories of Islamic manuscript production in coastal East Africa and provide comparative material for manuscript studies in other regions of Eastern Africa and the Indian Ocean.
Clinical Profiles of Children and Adolescents With Induced Laryngeal Obstruction (ILO) and Exercise Induced Laryngeal Obstruction (EILO)
Authors: Fujiki Robert Brinton , Olson-Greb Bryn , Thibeault Susan L. 
Published: August 2023

Purpose: To compare clinical profiles of pediatric patients with Induced Laryngeal Obstruction (ILO), Exercise Induced Laryngeal Obstruction (EILO), and EILO with non-exertion related secondary triggers (EILO+). Methods: A retrospective observational cohort design was employed. Four-hundred and twenty-three patients <18 years of age were identified from the electronic medical record of a large children’s hospital. All patients underwent evaluations with a laryngologist and speech-language pathologist and were diagnosed with EILO/ILO. Patients were divided into 3 groups based on dyspnea triggers reported in initial evaluations. Groups consisted of patients with EILO (N = 281), ILO (N = 30), and EILO+ (N = 112). Patient demographics, EILO/ILO symptoms, endoscopy findings, medical comorbidities, medical history, and EILO/ILO treatment information were extracted and compared across EILO/ILO subtypes. Results: Patients with EILO experienced higher rates of hyperventilation ( P < .001), sore throat ( P = .023), and chest pain ( P = .003). Patients with ILO were significantly younger in age ( P = .017) and presented with increased rates of nighttime symptoms ( P < .001), globus sensation ( P = .008), self-reported reflux symptoms ( P = .023), and history of gastrointestinal conditions ( P = .034). Patients with EILO+ were more likely to be female ( P = .037) and presented with higher prevalence of anxiety ( P = .003), ADHD ( P = .004), chest tightness ( P = .030), and cough ( P < .001). Conclusions: Patients with EILO, ILO, and EILO+ present with overlapping but unique clinical profiles. A prospective study is warranted to determine the etiology of these differences and clarify how the efficacy of EILO, ILO, and EILO+ treatment can be maximized. Level of Evidence: 4
International consensus on occupational therapy interventions for people with palliative care needs: A European Association for Palliative Care Group Concept Mapping study
Authors: Wæhrens Eva Ejlersen , Morgan Deidre D , la Cour Karen , Lyons Kathleen Doyle , Lozano Mario Lozano , De Carlo Marysia MR Prado , Rezende Gabriela , Pilegaard Marc Sampedro 
Published: August 2023

Background: While evidence shows that occupational therapists can play a key role in the care of people with palliative care needs, more knowledge about effective occupational therapy interventions for this group is needed. Aim: To identify, organise and prioritise intervention components considered to be effective within occupational therapy for people with palliative care needs from the perspective of occupational therapy clinicians, managers and researchers. Design: Group Concept Mapping utilising a mixed methods participatory approach. Using a focus prompt, participants brainstormed, sorted, labelled and rated generated statements about effective occupational therapy intervention components. Multidimensional scaling analysis and cluster analysis were conducted. Setting/Participants: Snowball recruitment was used to recruit participants. Participants included occupational therapists worldwide who were able to read and write in English and were working as clinicians, managers and/or researchers with occupational therapy interventions for people with palliative care needs. Results: Seventy-two occupational therapists from 15 countries participated in the study representing Asia ( n = 3, 20%), Europe ( n = 8, 53%), Oceania ( n = 2, 13%) and North America ( n = 2, 13%). A total of 117 statements were identified and organised into five clusters: (1) being client-centred, (2) promoting occupational engagement to optimise quality of life, (3) involving the social and relational environment, (4) enabling occupations and (5) facilitating occupational adaptation. Conclusions: Five clusters of core occupational therapy intervention components were considered to be effective when supporting people with palliative care needs. Research should use this knowledge to inform future occupational therapy interventions for this group of people.
The Ottoman International System: Power Projection, Interconnectedness, and the Autonomy of Frontier Polities
Authors: Balci Ali , Kardaş Tuncay 
Published: August 2023

This article posits that the Ottoman international system was built on three pillars: power projection, interconnectedness, and autonomy of frontier polities. While its military power projection dwarfed its great power rivals, cultural and organizational capacities of the Ottoman Empire extended its influence to areas out of its military reach. Occupying a central position in trade, pilgrimage, and diplomacy during the early modern period, the Ottoman Empire fostered connections throughout the wider Afro-Eurasian world. The flexible and almost independent status of the peripheral polities not only increased the survival capacity of the empire but also played a central role in the functioning of the Ottoman international system. Rather than presenting either a material or ideational perspective, the present study adopts a via-media approach, integrating both perspectives to elucidate the Ottoman international system, which persisted for nearly three centuries from the early 16th century to the late 18th century. Analyzing such a broad historical phenomenon, this article aims to enrich and contribute to the increasingly popularized historical and non-Western IR subfields. Additionally, it holds potential to deepen our comprehension of heterogeneous international systems and their modus operandi. Le système international ottoman : Projection de puissance, interconnexion et autonomie des territoires frontaliers
Strategies used by people with systemic sclerosis to perform valued occupations
Authors: Poole Janet L , Baldonado Monica , Powell Aubrie , Hukill Virginia Stofer 
Published: August 2023

Introduction: This study explored the strategies used by people with systemic sclerosis to perform valued obligatory (self-care), committed (home management, care of others, productivity), and discretionary (leisure and socialization) activities. Method: This cross-sectional study included a convenience sample of 92 people with systemic sclerosis who completed the Valued Life Activities Scale (VLA). The VLA categorizes activities into three main domains: obligatory, committed, and discretionary. Participants indicated the type of adaptive strategy used for each activity (assistive devices, personal assistance, limited frequency, and taking more time). Participants also completed a demographic questionnaire and measures of pain, fatigue, depression, and daily activity performance. Frequency counts were calculated for strategies used for each activity. One-way analyses of variance compared the mean use of strategies across the three domains (obligatory, committed, and discretionary). Pearson correlation coefficients calculated relationships between strategy use and pain, fatigue, depression, and daily activity performance. Results: Significantly, more strategies were used for committed activities compared to obligatory activities. Limiting the frequency of performing an activity was used significantly more for committed and discretionary activities than for obligatory activities. The least used strategies were assistive devices and assistance from another person. Fatigue and depression were related to strategy use, whereas pain and daily activity performance were not. Conclusion: People with systemic sclerosis use adaptive strategies to perform VLA. However, the strategies, most frequently used, such as taking more time or limiting the frequency of performing some activities, may result in relinquishing other valued activities.
Circular RNA 0000157 depletion protects human bronchial epithelioid cells from cigarette smoke extract-induced human bronchial epithelioid cell injury through the microRNA-149-5p/bromodomain containing 4 pathway
Authors: Song B , Wu S , Ye L , Jing Z , Cao J 
Published: August 2023

Background Circular RNA (circRNA) has been reported to regulate respiratory diseases. In the study, we aimed to elucidate the role of circ_0000157 in smoke-related chronic obstructive pulmonary disease (COPD) and the inner mechanism. Methods COPD-like cell injury was induced by treating human bronchial epithelioid cells (16HBE) with cigarette smoke extract (CSE). The expression of circ_0000157, miR-149-5p, bromodomain containing 4 (BRD4), BCL2-associated x protein (Bax) and B-cell lymphoma-2 (Bcl-2) was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) or Western blotting. Enzyme-linked immunosorbent assay was performed to detect interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. Malondialdehyde (MDA) production was detected by a lipid peroxidation MDA assay kit. Superoxide dismutase (SOD) activity was analyzed by a SOD activity assay kit. Results Circ_0000157 and BRD4 expression were upregulated, while miR-149-5p expression was downregulated in the blood of smokers with COPD and CSE-induced 16HBE cells compared with control groups. CSE treatment inhibited 16HBE cell proliferation and induced cell apoptosis, inflammation, and oxidative stress; however, these effects were remitted when circ_0000157 expression was decreased. In addition, circ_0000157 acted as a miR-149-5p sponge and regulated CSE-caused 16HBE cell damage by targeting miR-149-5p. The overexpression of BRD4, a target gene of miR-149-5p, attenuated the inhibitory effects of miR-149-5p introduction on CSE-induced cell damage. Further, circ_0000157 modulated BRD4 expression by associating with miR-149-5p in CSE-treated 16HBE cells. Conclusion Circ_0000157 knockdown ameliorated CSE-caused 16HBE cell damage by targeting the miR-149-5p/BRD4 pathway, providing a potential therapeutic strategy for clinic intervention in COPD.