bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of treatment regimens for patients with metastatic, locally advanced, or recurrent breast cancer carrying BRCA1/BRCA2 pathogenic variants: A network meta-analysis
Authors: Zhu Yingxuan , Li Yang , Liu Weida , Zhou Ruozhu , Tse Lap Ah , Wang Yang , Li Wei 
Published: February 2023

ObjectivePatients with breast cancer carrying BRCA1 and BRCA2 genetic alterations show poor prognoses. However, the efficacy of pharmacotherapies for patients with advanced breast cancer carrying BRCA1/2 pathogenic variants remains unclear. This study aimed to conduct a network meta-analysis to assess the efficacy and safety of various pharmacotherapies for patients with metastatic, locally advanced, or recurrent breast cancer carrying BRCA1/BRCA2 pathogenic variants.MethodsA literature search was conducted using Embase, PubMed, and Cochrane Library (CENTRAL), from inception to 11th May 2022. The references of included articles were screened to identify relevant literature. This network meta-analysis included patients with metastatic locally advanced or recurrent breast cancer who received pharmacotherapy and carried deleterious variants of BRCA1/2. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed for conducting and reporting this systematic meta-analysis. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method was employed to evaluate evidential certainty. Frequentist random-effect model was applied. Results of objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and rates of any-grade adverse events were presented.ResultsNine randomized controlled trials were obtained comprising six treatment regimens, including 1912 patients with pathogenic variants of BRCA1 and BRCA2. The orchestration of PARP inhibitors with platinum-based chemotherapy was found to be the most effective with a pooled odds ratio (OR) of 3.52 (95% CI 2.14, 5.78) for ORR; 1.53 (1.34,1.76), 3.05 (1.79, 5.19), and 5.80 (1.42, 23.77) for 3-, 12-, and 24-month PFS, respectively, and 1.04 (1.00, 1.07), 1.76 (1.25, 2.49) and 2.31 (1.41, 3.77) for 3-, 12-, and 36-month OS, respectively compared to those receiving non-platinum-based chemotherapy. However, it posed an elevated risk of some adverse events. Platinum-based chemotherapy alone or PARP inhibitors markedly improved ORR, PFS, and OS compared to non-platinum-based chemotherapy. Interestingly, platinum-based chemotherapy surpassed PARP inhibitors in terms of efficacy. Evidence on programmed death-ligand 1(PD-L1) inhibitors and sacituzumab govitecan (SG) suggested low quality and insignificant results.ConclusionsAmong all treatment regimens, PARP inhibitors with platinum exhibited the best efficacy, although with a trade-off of elevated risk of some types of adverse events. Future research on direct comparisons between different treatment regimens specifically targeting patients with breast cancer carrying BRCA1/2 pathogenic variants with a pre-specified adequate sample size is warranted.
Segmental chromosomal aberrations as the poor prognostic factor in children over 18 months with stage 3 neuroblastoma without MYCN amplification
Authors: Wieczorek Aleksandra , Szewczyk Katarzyna , Klekawka Tomasz , Stefanowicz Joanna , Ussowicz Marek , Drabik Grazyna , Pawinska-Wasikowska Katarzyna , Balwierz Walentyna 
Published: February 2023

IntroductionPatients with stage 3 neuroblastoma (NBL) according to International Neuroblastoma Staging System (INSS) without MYCN amplification represent a heterogenous group with respect to disease presentation and prognosis.MethodsRetrospective analysis of 40 stage 3 patients with NBL without MYCN amplification was performed. The prognostic value of age at diagnosis (under 18 vs over 18 months), International Neuroblastoma Pathology Classification (INPC) diagnostic category and presence of segmental or numerical chromosomes aberrations were evaluated, as well as biochemical markers. Array comparative genomic hybridization (aCGH) for analyzing copy number variations and Sanger sequencing for ALK point mutations were done.ResultsIn 12 patients (two patients under 18 months), segmental chromosomal aberrations (SCA) were found and numerical chromosomal aberrations (NCA) were found in 16 patients (14 patients under 18 months). In children over 18 months SCA were more common (p=0.0001). Unfavorable pathology was significantly correlated with SCA genomic profile (p=0.04) and age over 18 months (p=0.008). No therapy failures occurred in children with NCA profile over or under 18 months or in children under 18 months, irrespective of pathology and CGH results. Three treatment failures occurred in the SCA group, in one patient CGH profile was not available. For the whole group at 3, 5 and 10-year OS and DFS were 0.95 (95% CI 0.81-0.99), 0.91 (95% CI 0.77-0.97) and 0.91 (95% CI 0.77-0.97), and 0.95 (95% CI 0.90-0.99), 0.92 (95% CI 0.85-0.98) and 0.86 (95% CI 0.78-0.97), respectively. DFS was significantly lower in the SCA group than in the NCA group (3-years, 5-years, and 10-years DFS 0.92 (95% CI 0.53-0.95), 0.80 (95% CI 0.40-0.95) and 0.60 (95% CI 0.16-0.87) vs 1.0, 1.0 and 1.0, respectively, p=0.005).ConclusionsThe risk of treatment failure was higher in patients with SCA profile, but only in patients over 18 months. All relapses occurred in children having obtained the complete remission, with no previous radiotherapy. In patients over 18 months, SCA profile should be taken into consideration for therapy stratification as it increases the risk of relapse and this group may require more intensive treatment.
Physicians’ attitudes toward hypnotics for insomnia: A questionnaire-based study
Authors: Takeshima Masahiro , Aoki Yumi , Ie Kenya , Katsumoto Eiichi , Tsuru Eichi , Tsuboi Takashi , Inada Ken , Kise Morito , Watanabe Koichiro , Mishima Kazuo , Takaesu Yoshikazu 
Published: February 2023

IntroductionBenzodiazepines and non-benzodiazepines are still widely prescribed despite safety concerns and the introduction of novel hypnotics (orexin receptor antagonists [ORA] and melatonin receptor agonists [MRA]), which may be influenced by physicians’ attitudes toward hypnotics.MethodsA questionnaire survey was administered to 962 physicians between October 2021 and February 2022, investigating frequently prescribed hypnotics and the reasons for their selection.ResultsORA were the most frequently prescribed at 84.3%, followed by non-benzodiazepines (75.4%), MRA (57.1%), and benzodiazepines (54.3%). Compared to non-frequent prescribers of hypnotics, a logistic regression analysis showed that frequent ORA prescribers were more concerned with efficacy (odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.01–2.54, p = 0.044) and safety (OR: 4.52, 95% CI: 2.99–6.84, p &lt; 0.001), frequent MRA prescribers were more concerned with safety (OR: 2.48, 95% CI: 1.77–3.46, p &lt; 0.001), frequent non-benzodiazepine prescribers were more concerned with efficacy (OR: 4.19, 95% CI: 2.91–6.04, p &lt; 0.001), and frequent benzodiazepine prescribers were more concerned with efficacy (OR: 4.19, 95% CI: 2.91–6.04, p &lt; 0.001) but less concerned with safety (OR: 0.25, 95% CI: 0.16–0.39, p &lt; 0.001).DiscussionThis study suggested that physicians believed ORA to be an effective and safe hypnotic and were compelled to prescribe benzodiazepine and non-benzodiazepine frequently, choosing efficacy over safety.
Impact of COVID-19 pandemic on outpatient visit volume in cancer patients: Results of COMETA multicenter retrospective observational study
Authors: Frisardi Vincenza , Brunetti Oronzo , Abbinante Vincenza , Ardigò Marco , Caolo Giuseppina , Di Turi Annunziata , Torsello Alessandra , Napoli Christian , Mancini Rita , Belleudi Valeria , Addis Antonio , Di Bella Ornella , Ciliberto Gennaro , Neri Antonino , Corsini Romina , Ruggieri Patrizia , Pollorsi Chiara , Silvestris Nicola 
Published: February 2023

ObjectiveTo evaluate the impact of the COVID-19 pandemic on first and follow-up visits for cancer outpatients.MethodsThis is a multicenter retrospective observational study involving three Comprehensive Cancer Care Centers (CCCCs): IFO, including IRE and ISG in Rome, AUSL-IRCCS of Reggio Emilia, and IRCCS Giovanni Paolo II in Bari) and one oncology department in a Community Hospital (Saint'Andrea Hospital, Rome). From 1 January 2020 and 31 December 2021, we evaluated the volume of outpatient consultations (first visits and follow-up), comparing them with the pre-pandemic year (2019). Results were analyzed by quarter according to the Rt (real-time indicator used to assess the evolution of the pandemic). IFO and IRCCS Giovanni Paolo II were “COVID-free” while AUSL-IRCCS RE was a “COVID-mixed” Institute. Depending on the Rt, Sain't Andrea Hospital experienced a “swinging” organizational pathway (COVID-free/ COVID-mixed).ResultsRegarding the “first appointments”, in 2020 the healthcare facilities operating in the North and Center of Italy showed a downward trend. In 2021, only AUSL-IRCCS RE showed an upward trend. Regarding the “follow-up”, only AUSL IRCCS RE showed a slight up-trend in 2020. In 2021, IFO showed an increasing trend, while S. Andrea Hospital showed a negative plateau. Surprisingly, IRCCS Giovanni Paolo II in Bari showed an uptrend for both first appointment and follow-ups during pandemic and late pandemic except for the fourth quarter of 2021.ConclusionsDuring the first pandemic wave, no significant difference was observed amongst COVID-free and COVID-mixed Institutes and between CCCCs and a Community Hospital. In 2021 (“late pandemic year”), it has been more convenient to organize COVID-mixed pathway in the CCCCs rather than to keep the Institutions COVID-free. A swinging modality in the Community Hospital did not offer positive results in term of visit volumes. Our study about the impact of COVID-19 pandemic on visit volume in cancer outpatients may help health systems to optimize the post-pandemic use of resources and improve healthcare policies.
Expanding outpatient benefits package can reduce diabetes-related avoidable hospitalizations
Authors: Liu Hao-Ran , Chen Si-Yuan , Zhang Lan-Yue , Fu Hong-Qiao , Jian Wei-Yan 
Published: February 2023

ObjectiveTo evaluate the policy effect of replacing hospitalization service with outpatient service and reducing diabetes-related avoidable hospitalizations by improving outpatient benefits package.MethodsA database of hospital discharge from 2015 to 2017 in City Z was used. All diabetic inpatient cases enrolled in Urban Employee Basic Medical Insurance were selected as the intervention group, and diabetic inpatient cases enrolled in Urban and Rural Resident Basic Medical Insurance were selected as the control group. The Difference-in-Difference model was used to analyze the effect of improving outpatient benefits package level of diabetes from 1800 yuan (about $252.82) to 2400 yuan (about $337.09) per capita per year on avoidable hospitalization rate, average hospitalization cost and average length of stay.ResultsThe avoidable hospitalization rate of diabetes mellitus decreased by 0.21 percentage points (P &lt; 0.01), the average total cost of hospitalization increased by 7.89% (P &lt; 0.01), and the average length of stay per hospitalization increased by 5.63% (P &lt; 0.01).ConclusionsImproving the outpatient benefits package of diabetes can play a role in replacing hospitalization service with outpatient service, reducing diabetes-related avoidable hospitalizations, and reducing the disease burden and financial burden.
Feasibility of preservation of superior rectal artery plus dissection of lymph nodes around inferior mesenteric artery in laparoscopic resection for sigmoid colon cancer
Authors: Ren Haoyuan , Liu Yong , Zhang Mingran , An Liang 
Published: February 2023

BackgroundLimited data are available about superior rectal artery (SRA) preservation in laparoscopic resection for sigmoid colon cancer (SCC). This study aimed to evaluate the short-term and long-term efficacies of SRA preservation in laparoscopic radical resection for SCC.MethodsWe retrospectively analyzed 207 patients with SCC who underwent laparoscopic radical resection for SCC from January 2017 to June 2021. A total of 84 patients received lymph node clearance around the inferior mesenteric artery (IMA) root (D3 lymph node dissection) with preservation of SRA (SRA preservation group), and 123 patients received high ligation of the IMA (control group). The clinicopathological data of the two groups were compared, and Kaplan–Meier method was performed to estimate patient survival.ResultsCompared with the control group, the operation time of the SRA preservation group was longer (p &lt; 0.001), but the postoperative exhaust and defecation times were significantly shorter (p = 0.003, p &lt; 0.001). Two cases of postoperative ileus and four cases of anastomotic leakage were observed in the control group, whereas the SRA preservation group had none. However, no statistical difference was observed between the groups (p = 0.652, p = 0.248). The overall survival also showed no significant difference in (p = 0.436).ConclusionPreservation of SRA plus dissection of lymph nodes around IMA did not increase postoperative morbidity and mortality nor affect the prognosis of patients but increased the bowel blood supply, which may have a significant positive effect on the recovery of postoperative intestinal function and reduction of anastomotic leakage.
Clinical characteristics of primary atrial tumor and their diagnostic value: A retrospective study of 10 years
Authors: Wang Qian , Jiang Yue , Lin Li , Li Sheng , Lv Jiagao , Chen Jun 
Published: February 2023

BackgroundPrimary atrial tumors are relatively rare and predominantly benign. However, some atrial tumors may be malignant and are associated with poor outcome. Currently, it is hard to determine the malignance of atrial tumors by preoperative clinical presentation or by echocardiography. We aimed to report the difference in the clinical characteristics of patients with benign and malignant atrial tumor.MethodsThis was a single-center retrospective study. A total of 194 patients with primary atrial tumor admitted to our center between 2012 and 2021 were included. The clinical characteristics of patients with benign and malignant tumor were compared.ResultsBenign and malignant tumor accounted for 93% (n = 180) and 7% (n = 14) of the total patients, respectively. Malignant atrial tumor tended to occur in younger patients (P &lt; 0.05), was more likely to be located at the right atrium (P &lt; 0.05), and tended to attach to the atrial wall or valve instead of the atrial septum. Fever symptoms were more common in patients with malignant tumors than in patients with benign tumors (P &lt; 0.05). Compared to benign tumor, patients with malignant atrial tumor also demonstrated higher rates of fever, lower rates of increasing fibrinogen, increased blood glucose (P &lt; 0.05), significantly longer prothrombin time, and lower prothrombin activity (P &lt; 0.05). Patients with malignant primary atrial tumor had higher mortality rate, tumor metastasis rate, and tumor recurrence rate than patients with benign primary atrial tumor (P &lt; 0.05).ConclusionWe compared the clinical characteristics of patients with benign and malignant atrial tumor. These findings provide valuable information to preoperatively determine the malignance of atrial tumor and thus guide surgical treatment.
PENGARUH JENIS PEREKAT DAN UKURAN PARTIKEL SERAT POHON PISANG (Musa acuminate) PADA PEMBUATAN FIBER BOARD UNTUK APLIKASI PLAFON (Variabel jenis perekat)
Authors: Maxi Millian  , Bambang Kusmartono  
Published: February 2023

Fiber board merupakan sebuah panel homogen yang dibuat dari serat lingo sellulosa, yang dikombinasi dengan resin sintetik atau bahan perekat lainnya, yang direkatkan secara bersamaan dalam keadaan panas dan bertekanan. Bahan additive dapat ditambahkan selama proses pembuatan untuk merubah atau memperbaiki sifat yang dihasilkan. Fiber board ini biasanya dimanfaatkan sebagai panel, isolasi, dan cover pada kontruksi bangunan dimana dibutuhkan kekuatan pada setiap lembarannya. Selain itu juga dapat digunakan sebagai komponen pada pintu, cabinet, almari, dan peredam suara.
Penelitian ini dilakukan untuk memperoleh Fiber board dari pelepah pisang dengan variabel jenis perekat. Pelepah pisang di jemur sampai kering kemudian di giling. Untuk proses pembuatan fiber board yaitu siapkan serat, urea formaldehyde, dan jenis perekat (PVAC, styrofoam, gondorukem, Polistirena resin, dan Poly Ethylene Theraphalate) dengan masing-masing berat 250 gr kemudian di aduk menjadi satu setelah itu di masukan kedalam cetakan yang berukuran 10x20x15cm yang diberi alas besi yang telah dilapisi alumunium foil, lalu ditekan dan cetakan diangkat ke atas degan cara pelan-pelan setelah itu di atasnya di kasih besi juga,kemudian di masukkan kedalan alat kempa panas, di tinggu sampai 10 menit.
PENGAMBILAN MINYAK ATSIRI DARI RIMPANG TEMULAWAK DENGAN PROSES EKSTRAKSI MENGGUNAKAN PELARUT N-HEKSAN (Variabel Volume Pelarut dan Waktu Ekstraksi)
Authors: Dwiki Novendratama  , Ganjar Andaka  
Published: February 2023

Temulawak (Curcuma xantorrhiza Roxb.) merupakan salah satu jenis tanaman obat penting yang banyak digunakan sebagai bahan baku industri obat di Indonesia. Rimpang temulawak mengandung zat kurkumin, minyak atsiri, pati, protein, lemak, selulosa dan minyak. Di antara komponen tersebut yang paling banyak kegunaannya adalah pati, minyak atsiri dan kurkuminoid.
Penelitian ini bertujuan mengetahui pengaruh jumlah volume pelarut dan waktu ekstraksi dalam pengambilan minyak temulawak dengan metode ekstraksi menggunakan pelarut n-heksan. Temulawak dengan ukuran yang sudah terbentuk serbuk disiapkan. Kemudian serbuk temulawak ditimbang sebanyak 100 g untuk dilakukan proses ekstraksi menggunakan pelarut n-heksan dengan jumlah volume pelarut yang digunakan sebagai variabel sebanyak 300 - 500 mL dengan suhu yang digunakan 60-62oC dan kecepatan pengadukan yang digunakan 300 rpm selama 120 menit. Sedangkan untuk variabel waktu ekstraksi digunakan waktu selama 60-180 menit, dengan jumlah volume pelarut n-heksan sebanyak 500 mL. Setelah sampel selesai di ekstraksi, selanjutnya hasil ekstraksi difiltrasi. Hasil dari filtrasi kemudian dilakukan proses distilasi hingga didapatkan minyak yang tertinggal di labu distilasi (residu) dan sudah tidak ada yang menetes lagi di penampung hasil distilasi (distilat). Sampel dituang ke dalam botol penampung yang sudah diketahui beratnya. Sehingga dapat diketahui berat sampel yang terambil untuk mencari persentase minyak terambil.
Dari hasil penelitian dengan jumlah bahan 100 g didapatkan bahwa semakin banyak jumlah volume pelarut yang digunakan maka persentase randemen semakin banyak dan semakin lama waktu ekstraksi maka persentase randemen semakin banyak juga. Pada variabel jumlah volume pelarut didapatkan jumlah volume pelarut yang optimal pada 500 mL n-heksan dengan persentase randemen sebesar 13,3%. Sedangkan untuk variabel waktu ekstraksi didapatkan kondisi optimal pada lama waktu ekstraksi 150 menit dengan persen minyak terambil sebesar 14%.
Clarification of recycled water of gas cleaning of a blast furnace using a water-dispersible flocculant
Authors: Еремеев Д.Н. , Груздев С.В. 
Published: February 2023

Приведены результаты лабораторного тестирования по подбору оптимального флокулянта для осветления оборотной воды газоочистки доменной печи. Лабораторное тестирование проводили по стандартной методике отстаивания (осветления) в стаканах. Показано, что применение жидкого вододисперсионного флокулянта АТЕ12520 позволяет успешно удалять взвешенные вещества и мутность из оборотной воды газоочистки. Предложенная программа реагентной обработки была рекомендована к промышленным испытаниям для осветления оборотной воды системы газоочистки доменной печи одного из металлургических заводов в России. Рекомендуемый для испытаний диапазон дозировки флокулянта АТЕ12520 (по товарному реагенту) в расчете на сточную воду, поступающую в радиальный отстойник, составляет 0,3–0,5 г/м3.
The results of laboratory testing of choosing the optimal flocculant for clarification of recycled water of blast furnace gas cleaning are presented. Laboratory testing was carried out according to the standard method of sedimentation (clarification) in glasses. It has been shown that the use of ATE 12520 liquid water-dispersible flocculant provides for the successful removal of suspended solids and turbidity from gas cleaning recycled water. The proposed chemical treatment program was recommended for commercial testing of the clarification system of gas cleaning recycled water of a blast furnace at one of the ironworks in Russia. The ATE 12520 flocculant dosage range recommended for testing (as commercial chemical) in terms of wastewater supplied to the circular sedimentation tank is 0.3–0.5 g/m3.
Combining ultrasonic treatment and ozonation for wastewater treatment of dyeing plants
Authors: Пилипенко М.В. , Дубина А.В. , Лихавицкий В.В. 
Published: February 2023

Представлены результаты исследования эффективности очистки модельных и реальных сточных вод красильно-отделочных производств комбинированием ультразвуковой обработки и озонирования. Изучено влияние времени обработки, концентрации озона в газовой смеси на эффективность очистки. Эффективность очистки оценивали по оптической плотности и ХПК. В результате исследований было показано повышение эффективности очистки сточной воды до 12% при комбинировании флотации озоновоздушной смесью вместо воздуха с ультразвуковой обработкой. Данный эффект может быть связан, в первую очередь, с диспергированием пузырьков озоновоздушной смеси, что приводит к увеличению их суммарной поверхности и, соответственно, к увеличению кинетики массообмена – растворения озона.
The results of studying the efficiency of purification of model and real wastewater from dyeing and finishing works by combining ultrasonic treatment and ozonation are presented. The effect of the treatment time, ozone concentration in the gas mixture on the purification efficiency has been studied. The purification efficiency was evaluated by optical density and COD. As a result of the study up to 12% increase in the efficiency of wastewater treatment was shown while combining flotation with ozone-air mixture instead of air with ultrasonic treatment. This effect can be associated, first of all, with the dispersion of ozone-air mixture bubbles that results in an increase in the surface area, and, accordingly, in an increase in the kinetics of mass transfer – ozone dissolution.
LOGÍSTICA REVERSA EM GERAL E LOGÍSTICA REVERSA DE EMBALAGENS:
Authors: Rohrich Sandra 
Published: February 2023

O presente artigo tem por objetivo levantar os marcos legais para a logística reversa em geral e especialmente para a logística reversa de embalagens, tendo por referência o Acordo Setorial de Embalagens e os seus desdobramentos. Como fundamentação teórica a logística reversa das embalagens representa uma alternativa promissora na gestão de resíduos, tanto do ponto de vista econômico como ambiental, contribuindo, sobretudo, para fortalecimento dos princípios da economia circular. Trata-se de uma pesquisa com natureza descritiva e qualitativa, possui recorte longitudinal, abrangendo o período de 2002 a 2022. Como principais conclusões verificou-se que não existe atribuição de responsabilidade financeira sobre as embalagens colocadas no mercado, ficando assim, tanto os fabricantes, quanto os comerciantes e os consumidores, apenas com a responsabilidade de encaminhar os resíduos para as cooperativas de reciclagem, que recebem contrapartida financeira somente das prefeituras. O estudo evidenciou ainda que, apesar de um histórico de 20 anos de regulação desde a primeira iniciativa em 2002, em muitos aspectos os avanços para a logística reversa de embalagens ainda são lentos.