P-583 Is donor age a major factor in egg donation for clinical outcome?
Authors: Mokra K , Dorofeyeva U , Aydin B , Kozyra O , Karimova H , Gudkova D , Kotlyarova O , Lytvyn B , Volodymyr V , Yetim I 
Published: June 2023

Abstract

Study question
How significant is the age factor for clinical success of the controlled ovarian stimulation cycles (COS) in various age subgroups of the egg donors?

Summary answer
There is no significant negative impact of the donor age for clinical outcome in egg donation cycle.

What is known already
It was shown that the donor age was an independent factor for ovarian stimulation cycles outcomes, which could predict over 80% of IVF success. It also reported that there were no associations between donor oocyte harvest and probability of live birth, adjusting for donor age. Different studies showed that the donor age less than 25 years old doesn’t predict better embryo development or clinical pregnancy outcome for egg donation cycles in the same age group of recipients.

Study design, size, duration
Three IVF centers having been involved in this study, data used from donors (n = 6319) examined between 2019-2022, they were divided into 3 age groups (A: 19-22, B: 23-29, C: ≥30 years). COS protocols were analyzed including different parameters: number of oocytes retrieved, antral follicle count (AFC), maturation rate (MR), utilization rate (UR) and follicle-to-oocyte index (FOI). The association between COS cycle parameters and the age characteristics was assessed by T-Student (parametric) or U-Mann-Whitney (non-parametric).

Participants/materials, setting, methods
In group A mean age 19-22 years , group B 23-29 years and group C - over 30 years donors 717, 1000, 1000 respectively COS protocols were analysed including different parameters such as: number of oocytes retrieved, maturation rate (MR), utilization rate (UR) and follicle-to-oocyte index (FOI).

Main results and the role of chance
Mean age in groups: A (n = 717) - 21,0±1,1; B (n = 1000) - 26,3±1,9 and in group C (n = 1000) - 31,6±1,5. The mean number (SD) of oocytes harvested: 26,94 (12,40), 25,98 (12,03) and 23,22 (11,49) oocytes in groups A, B and C respectively. The same tendency with no statistical difference was observed for values of AFC: 33,24 (14,55), 32,41 (13,86) and 29,77 (12,98).
Values of FOI in A and B groups were higher than in C: 81,85 (17,37), 81,06 (18,54) and 78,24 (17,97) in groups A, B and C, respectively with statistically proven difference (p = &lt;0.05) for both. MR was higher in C group (83±15%) vs A (80±16%) and B (81±16%) with proven statistical significance (p = &lt;0.05). Recipients of group A (average age 33,05) - received 94,55% FR, 66,15% used BR and % 57,84 CPR. Group B recipients (age average 35,08) - 92,88% FR, 61,69 used BR and 54,77% CPR. Recipients of Group C ( average age 33,07) - 94,55% FR, 60,01% used BR and 59,05% CPR.

Limitations, reasons for caution
This study is limited by its retrospective nature and more studies are necessary to investigate not only COS outcomes but also the impact of the age related factors on pregnancy rates.

Wider implications of the findings
Our findings may bring a controversial spotlight on the doubtful issue of the relationship between donor age and clinical and embryo outcomes of the COS programs.

Trial registration number
not applicable