bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Physicochemical Properties of Sago Starch (Metroxylon spp.) Varieties Rondo from Papua and Meranti from Riau
Authors: Kiptiyah Sakina Yeti , Virdamayana Khaerunnisa , Khairiah Khairiah 
Published: January 2025

Indonesia has more than 90% of the world's sago area, 85% of which is in Papua Province and Western Indonesia, including Meranti Islands Regency and Riau Province. According to the Ministry of Agriculture of the Republic of Indonesia, the western region of Indonesia is the largest producer of sago production in Indonesia. The purpose of this study was to determine the physicochemical properties of sago starch of the rondo variety and the physicochemical properties of sago starch of the meranti variety. This research design used statistical analysis using a normality test then a uniformity test and continued with a repeated t test 6 times on sago flour from the Papua Rondo cultivar and the meranti cultivar from Riau. The parameters measured in this study were swelling and solubility, moisture content and carbohydrate content. The results of the study concluded that there were differences between the two types of arrowroot starch. The water content of sago starch (8.25%) of the rondo variety from Papua had a real influence on the water content of sago starch (13.5%) of the meranti variety of Riau, but did not have a real influence on its swelling capacity, solubility and carbohydrate content. An innovative product that is in accordance with the characteristics of sago flour from the rondo variety from Papua and the meranti variety from Riau is a biscuit.
The Appearance of Whale Sharks (Rhincodon typus) Based on Environmental Factors in Kwatisore Waters, Nabire Regency, Central Papua Province
Authors: Maruanaya Yan 
Published: January 2025

The appearance of whale sharks (Rhincodon typus) is related to the availability of food in a water area, and it has become a tourist attraction which requires integrated management to prevent it from becoming threats to whale sharks. The appearance of whale sharks is regular throughout the year with the highest number of individuals occurring only in Kwatisore waters. This study aims to examine the bio-ecology of whale sharks related to their appearance based on individuals, quantity, time of appearance, and sex. Primary data collection carried out from January 16 to March 26, 2023, using a census method on 4 units of fishing lift-net deployed in Kwatisore waters. The results showed that 21 individual whale sharks appeared with a total of 225 occurrences in January, 245 occurrences in February, and 248 occurrences in March. There was also one new individual that migrated into Kwatisore waters with the ID number 184. Whale shark appearances mostly happened in the morning and the appearance percentage was 100% male with a total length ranging from 3 to 7.5 m. Environmental factors in Kwatisore waters were in normal conditions supporting the appearance of whale sharks. Keywords: Whale sharks, appearance, new individual, environmental factors
Political Citizenship : Protection of Prisoners Political Rights by KPU Ciamis in General Elections 2024
Authors: Pratama Aldi Septian , Gunawan Hendra , Gustaman Randy Fadillah 
Published: January 2025

This research discusses the protection of political rights of prisoners of Lapas Kelas IIB Ciamis by KPU Ciamis in General Election 2024. This study uses political citizenship to describe how the prisoners' struggle and the KPU's efforts to protect the political rights of prisoners through the four dimensions of citizenship politics. This research is a qualitative research with a case study method. The results show that there are still 17 out of 322 prisoners who are not protected by their political rights and cannot vote in elections. The struggle of prisoners includes four dimensions of citizenship politics, namely the dimensions of membership, legal status, political rights, and participation. KPU also applies new methods and improves the process of protecting the political rights of prisoners. Interaction occurred between the prisoners and the KPU and conflicts were inevitable which caused 17 prisoners to lose their political rights.
Etiopathogenic and Therapeutic Considerations in a Multiple Sclerosis Case with Acute Toxic Hepatitis
Authors: Dumitru-Martoiu Maria Melania , Petrescu Simona , Panea Cristina Aura 
Published: January 2025

Background/Objectives: In multiple sclerosis (MS) there are many therapeutic options, most of the available drugs causing drug-induced liver injury, after the first infusions. A wide variety of other drugs may cause a spectrum of liver disease, from simple anti-pyretic drugs like paracetamol to multiple dietary herb supplements like Ashwagandha. Methods: 39 years female patient, diagnosed with MS, previously treated with Glatiramer Acetate, Interferon-beta, and current immunomodulatory treatment with Natalizumab (infusion no. 81), with recent history of an airway infection for which she took 4-5 capsules of Paracetamol per day for 7 days, and consumption of dietary supplement with Ashwagandha herbs, who presented with jaundice, pruritus, and lower limbs ecchymoses. Results: Laboratory results revealed higher aminotransferases levels, total bilirubin, and alkaline phosphatase. Screening for autoimmune and infectious hepatitis was negative. The scenario of a toxic hepatitis induced by recently used drugs (Ashwagandha dietary herb supplement and Paracetamol) made the medical team to start therapy with oral prednisone. The clinical and laboratory results progressively improved, with normal levels in liver enzymes and bilirubin, with no further increase after discontinuation of corticosteroid therapy and dietary herb supplement. Conclusions: This case highlights the difficulty to establish the multiple etiologies and the management of an acute hepatitis in a MS patient with Natalizumab as immunomodulatory treatment, a drug that can induce liver injury after the first infusions, and with recent history of ingestion of toxic hepatic drugs.
Humeral Shaft Stress Fracture Completion in a Weight Lifter
Authors: Zhu Allen C. , Lee Cody , Strelzow Jason , Erdman Mary Kate 
Published: January 2025

Case:
A 34-year-old man, amateur weight lifter presented with acute worsening of right shoulder pain after 5 months of prodromal, progressive, atraumatic pain. Imaging showed a short oblique proximal third humeral shaft fracture without evidence of other osseous abnormalities. He was treated operatively with open reduction and internal fixation, healed uneventfully, and returned to weight lifting within 3 months.

Conclusion:
Humeral shaft stress fractures most commonly occur in athletes or military personnel who engage in repetitive overhead activity. It is important to include stress fracture on the differential diagnosis for chronic pain in the upper extremity, especially in a physically active patient.
Extensor Pollicis Longus Tendon Rupture With Concomitant Electrodiagnostic and MRI Findings of Posterior Interosseous Nerve Palsy
Authors: Lin James S. , Kakar Sanjeev , Shin Alexander Y. , Bishop Allen T. 
Published: January 2025

Cases:
Two patients with spontaneous loss of thumb interphalangeal joint extension were referred after history, electrodiagnostic, and/or magnetic resonance imaging (MRI) findings were felt to demonstrate a posterior interosseous nerve (PIN) palsy. Subsequent physical examination and additional directed studies suggested an alternative explanation: rupture of the extensor pollicis longus (EPL) tendon, subsequently confirmed at surgery. An extensor indicis proprius to EPL transfer restored thumb function.

Conclusion:
Electrodiagnostic and MRI changes consistent with diffuse PIN palsy may occur in the setting of EPL rupture. An accurate diagnosis of EPL dysfunction requires careful physical examination and confirmatory imaging. Further study of this previously unreported phenomenon is required.
Pillar arrays as tunable interfacial barriers for microphysiological systems
Authors: Healy Kevin , Goswami Ishan , Kim Yongdeok , Neiman Gabriel , Siemons Brian , Velazquez Jazmin , Yazgan Kerem , Ng Tammy 
Published: January 2025

Abstract

We report on the design and fabrication of a novel circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to inconsistent pore size, complex fabrication and device assembly, and lack of tunability using a scalable design. Our pillar array overcomes these limitations by providing precise control over pore size, porosity, and hydraulic resistance through simple modifications of pillar dimensions. Serving as an interface between microfluidic compartments, it facilitates cell aggregation for tissue formation and acts as a tunable diffusion barrier that mimics diffusion in vivo. We demonstrate the utility of barrier design to engineer physiologically relevant cardiac microtissues and a heterotypic model with vasculature within the device. Its tunable properties offer significant potential for drug screening/testing and disease modeling, enabling comparisons of drug permeability and cell migration in MPS tissue with or without vasculature.
Cultural Norms and Practices of Birth Preparedness among Indigenous Maasai Women in Northern Tanzania: A Descriptive Qualitative Study
Authors: Chanimbaga Bithia A. , Oguma Erick Donard , Moshi Fabiola Vincent , Kibusi Stephen Methew 
Published: January 2025

Abstract

Background: Preventable maternal morbidities and mortalities due to pregnancy-related complications can arise at any stage in pregnancy, delivery, and after. Despite efforts to encourage women to give birth in healthcare facilities, improvement has remained stagnant, particularly in remote Indigenous Maasai populationsin northern Tanzania. The study aims to explore the cultural norms and birth preparedness practices among Indigenous Maasai women in Northern Tanzania.
Methods: The study employed a descriptive qualitative study design, which was conducted from 11 April 2024 to 31 May 2024, among Indigenous Maasai women. In-depth interviews were conducted with 7 newly delivered Indigenous Maasai women, and three focus group discussions with 30 Indigenous Maasai elderly women. The thematic analysis with inductive approach was used to analyze the qualitative data.
Results: The study findings identified five overarching themes and 16 sub-themes, shedding light on the prevalent adherence to cultural norms and traditional practices surrounding childbirth. The themes encompassed traditional preparation for childbirth, culturally rooted approaches to maternal well-being, ritualistic practices during pregnancy and delivery, the collaborative roles of husbands within the family, and cultural norms associated with newborn care. These themes highlight the intricate interplay between cultural traditions and maternal health practices in the study context.
Conclusion: The study's findings reveal that Indigenous Maasai women in Tanzania adhere to traditional birth practices, which include the utilization of herbal medications and dietary modifications during pregnancy, labor, and postpartum. Their husbands play a crucial role in determining the birth location and providing assistance during labor and delivery, with a preference for traditional birth assistants (TBAs). This preference for TBAs during care and delivery increases the risk of complications for both mothers and newborns. Therefore, the study's findings emphasize an urgent need for community health educational programs focused on creating awareness of the effects of traditional practices such as restriction of food intake during pregnancy and inadequate use of skilled birth attendants among the study population to enhance maternal well-being.
Exploring a multi-omics study of micronutrients and colon cancer risk
Authors: Wu Weiqiang , Gao Feng , Gao ZhouYu , Gao Hua , Min Haoyun , Wang Ximing , Chen Jianliang , Xu Ming , Zou Min , Gui Mingbin , Wang Yanan , Lv Yang , Chang Dongmin 
Published: January 2025

Abstract

Background
Colorectal cancer (CRC) ranks as the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Approximately 95% of its histologic subtypes are colon adenocarcinoma (COAD). To date, numerous studies have investigated the potential impact of circulating microelements on COAD. However, the causal association between mirculating microelements and COAD remains unclear. Therefore, our study implemented two-sample Mendelian randomization (MR) analyses to explore the causal effect.
Methods
The two-sample MR analysis, involving five methods, was designed to assess the relevance of the above genetic variants. Serval sensitivity analysis were performed for strength credibility for MR results.
Results
The current research revealed a negative association between increased selenium levels and COAD risk, while circulating zinc levels exhibited a positive association with COAD risk. Sensitivity analyses indicated no heterogeneity or polymorphism among instrumental variables.
Conclusion
Current research suggests genetic evidence of causal effects of circulating microelement on COAD, and provide valuable insights into strategies for COAD prevention and treatment.
Ischemic Heart Disease Mortality and Metabolic Risk Factors: A Global Analysis of Gender Disparities and Regional Variations (1980–2021)
Authors: Li Huili , Xiao Fei , Chen Jiaying , Wang Jiarui , Chen Yuanlu , Li Zhenyu , Lin Peirong , Wang Sheng 
Published: January 2025

Abstract

The mortality rate and the number of deaths from ischemic heart disease (IHD) in developing regions have surpassed those in developed regions. Since 1980, the global number of IHD deaths, disability-adjusted life years (DALY), years of life lost (YLL), and years lived with disability (YLD) have significantly increased, particularly in regions with medium and high Social Development Index (SDI). Although the overall mortality rate has declined, developing countries, especially those in the medium SDI and low-medium SDI regions, are facing a greater burden of death. In the 1990s, while the number of IHD deaths increased, the socio-economic development level (SDI) also improved. However, over the past 30 years, the number of deaths in medium SDI regions, especially in China and Central Asia, has risen sharply, with these regions experiencing a faster increase in mortality rates. In contrast, the number of deaths in high SDI regions has steadily declined. The IHD mortality rate among men is generally higher than that of women, and the gender gap may continue to widen. Globally, the main risk factors for IHD deaths include high systolic blood pressure, high low-density lipoprotein (LDL), smoking, and high blood sugar. With improvements in health management in developed regions, deaths caused by metabolic risk factors have significantly declined. However, risk factors in developing countries, particularly in low-income and middle-income regions, remain significant. Air pollution, smoking, and other factors continue to be major health threats.
Heavy metals and prostate cancer: a new study with new findings
Authors: Coradduzza Donatella , Congiargiu Antonella , Sanna Andrea , Lorenzo Biagio , Marra Sonia , Cossu Maurizio , Tedde Alessandro , Miglio Maria Rosaria , Zinellu Angelo , Mangoni Arduino A. , Cogoni Alessio Aligio , Madonia Massimo , Carru Ciriaco , Medici Serenella 
Published: January 2025

Abstract

Heavy metals influence the development of several health conditions, including inflammation and cancer. This study investigates the relationship between heavy metal concentrations in plasma and urine, and the presence of benign prostatic hyperplasia (BPH), precancerous lesions (PL), and prostate cancer (PC). The influence of age, total PSA levels, hemoglobin concentrations, and the monocyte-to-lymphocyte ratio (MLR) is also analyzed across the three groups: BPH, PL, and PC. Our findings reveal significant differences in vanadium and antimony concentrations in plasma, suggesting a potential role in prostate disease pathophysiology. Notably, lower plasma antimony concentrations are associated with an increased risk of PC, while plasma vanadium concentrations are significantly higher in the PL group. Regression analysis further supports the association between heavy metal concentrations and the risk of PL and PC, highlighting the potential of vanadium and copper as biomarkers or therapeutic targets for prostate health. The study also explores the impact of lead exposure on prostate cancer risk, revealing a significant association between urine lead concentration and PC. These findings underscore the complex interaction between heavy metal concentrations and prostate disease risk, emphasizing the need for further research to elucidate underlying mechanisms and explore therapeutic interventions.
Effort-reward-imbalance, burnout, and physical pain mediate the relationship between overcommitment and depression in German Emergency Medical Technicians
Authors: Manns Laura , Vögele Claus , Stammet Pascal , Schulz André 
Published: January 2025

Abstract

Background: Overcommitment (OC) is highly prevalent in health care employees, and may predict depression symptoms. The literature suggests that the relationship between OC and depression is mediated by Effort-Reward-Imbalance (ERI), burnout and physical pain. This study tested a two-step mediation effect between OC and depression by ERI in a first, and burnout and physical pain in a second step using a cohort of German Emergency Medical Technicians (EMTs).
Methods: A cross-sectional study was carried out on a volunteer sample of 303 EMTs in Germany. OC and ERI were assessed using the ERI questionnaire, burnout with the Maslach Burnout Inventory, physical pain with the Short Form 36, and depression with the BDI-II. The relationship between these variables was tested using a mediation analysis.
Results: We found a partial mediation effect between OC and depression via ERI, burnout (emotional exhaustion, personal accomplishment) and physical pain. The mediation effect of emotional exhaustion is significantly higher than those of depersonalization and physical pain.
Conclusions: The partial mediation effect suggests the validity of our model assumptions, but also indicates direct relationships between variables (i.e. OC, ERI and depression). The identification of emotional exhaustion as key mediator implies that prevention and intervention approaches in EMTs should be based on this indicator.
Abordagem não-farmacológica para a dor pélvica de mulheres com endometriose
Authors: Damaceno Malu da Silva , Rodrigues Vanda Palmarella , Oliveira Zulmerinda Meira , Santos Flavia Pedro dos Anjos 
Published: January 2025

Objetivo: Conhecer por meio da literatura os tratamentos não farmacológicos para o alívio da dor pélvica em mulheres com diagnóstico de endometriose. Materiais e métodos: Revisão integrativa conduzida nas bases de dados da Biblioteca Virtual em Saúde, Medical Literature Analysis and Retrieval System Online, Literatura Latino-Americana e do Caribe em Ciências da Saúde, e Base de Dados de Enfermagem nos meses de março e abril de 2023, seguindo os critérios de inclusão: textos completos publicados nos idiomas português, inglês e espanhol, indexados nas referidas bases de dados nos últimos cinco anos. Foram selecionados dez estudos para serem analisados. Resultados e discussão: O estudo evidenciou que os hábitos de vida com adesão à alimentação mais saudável e à prática de atividades físicas, contribuem para o alívio da dor pélvica em mulheres com endometriose. As Práticas Integrativas e Complementares também se apresentam como novas estratégias de tratamento não-farmacológicos, pois desempenham papel importante para o tratamento da dor na perspectiva do cuidado integral. Considerações finais: A mulher pode encontrar diversos obstáculos para aderir às Práticas Integrativas e Complementares e ao estilo de vida saudável, entre as quais destacam-se os aspectos socioeconômicos, dificuldade de acesso aos serviços que ofertem essas práticas bem como escassez de profissionais capacitados para atuarem nessa abordagem.
Palavras-chave: Mulher; Endometriose; Dor pélvica; Tratamento; Terapias alternativas.
Reversal of Mucin 1 Reduction-Induced Enterocyte Apoptosis by Retinoic Acid through the PI3K/AKT Signaling Pathway in an In vitro Model of Necrotizing Enterocolitis
Authors: Su Qian , Chen Li , Xu Yanzhen , Feng Jinxing , Yu Jialin , Zhang Zhaoxia , Yu Zhangbin , Liu Dong 
Published: January 2025

Objective:
This study aimed to investigate the roles of Mucin 1 (MUC1), the
PI3K/AKT pathway, and enterocyte apoptosis in Necrotizing Enterocolitis (NEC).

Methods:
Using an NEC Caco-2 cell model, retinoic acid treatment and MUC1 gene
silencing were employed. Flow cytometry was used to assess apoptosis, while
quantitative PCR and western blot analyses were conducted to evaluate the gene and
protein expressions of MUC1, PI3K, Akt, and factors related to apoptotic modulation.

Results:
In comparison to the control group, NEC induction resulted in a significant
reduction in MUC1 expression, accompanied by an elevation in enterocyte apoptosis.
In NEC and Si-MUC1 Caco-2 cells, downregulation of PI3K/AKT signals and Bcl-2 was
observed, while upregulation of Bax, CytoC, and Caspase 3 at both mRNA and protein
levels was prominent. Retinoic acid supplementation exhibited a noteworthy increase
in MUC1, AKT, and Bcl-2 mRNA and protein expressions, coupled with a decrease in
Bax, CytoC, and Caspase 3, thereby mitigating apoptosis in NEC.

Conclusion:
Our findings suggested that reduced MUC1 expression in NEC
contributes to the upregulation of enterocyte mitochondrial apoptosis through the
PI3K/AKT signaling pathway. Retinoic acid supplementation emerges as a potential
therapeutic strategy for NEC, demonstrating its ability to upregulate MUC1 expression
and attenuate apoptosis via the PI3K/AKT signaling pathway.
Modulating Ferroptosis: A Novel Approach to Promote Neural Repair in Brain Injury
Authors: Liu Yanlin , Guo Ying , Zhou Huixin , Liu Yuxin , Jin Yuting , Luo Kaitao , Dou Xiaobing 
Published: January 2025

Abstract:
The increasing prevalence of brain injuries resulting in cognitive and motor function impairments
poses a substantial global medical challenge. Nerve repair therapies offer promise for addressing
brain injury-related disorders. Ferroptosis, as a cell death mechanism associated with oxidative
stress and inflammation. Certain ferroptosis inhibitors, such as iron chelators and antioxidants,
exhibit therapeutic potential for brain injury-related conditions. This review explores the fundamental
processes and associated mechanisms that regulate neural repair by inhibiting ferroptosis, thereby
alleviating brain injury and promoting neuroregeneration. Furthermore, it examines the action mechanisms
and potential therapeutic applications of ferroptosis inhibitors in neural repair, aiming to provide
novel insights for treating brain injuries.