bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the social dimensions of resilience: The role of the Social Sciences in Disaster Risk Reduction, Climate Action, and Sustainable Development
Authors: Imperiale Angelo Jonas , Vanclay Frank 
Published: August 2023

AbstractThis special issue contributes to building an integrated social science perspective on resilience and resilience‐building. The articles in this issue provide theoretical reflections and empirical insights on two dimensions that characterize resilience in society. The first (local community dimension) comprises the set of community resources, services, adaptive, transformative and coping capacities, processes, actions and behaviors that enable communities to learn from crises, disasters and past failures and transform toward sustainability in localities (community resilience). The second (governance dimension) comprises the set of adaptive and transformative governance strategies and assessment frameworks that enable social learning and sustainability transformation to be strengthened in localities and scaled up across multiple governance levels (social resilience). This special issue provides a theoretical common‐ground and practical pathways to define resilience and to support recovery and development planning to enhance resilience in society in order to achieve effective disaster risk reduction and climate action for sustainable development.
Eco‐friendly and Efficient Synthesis of Water‐soluble MoS2 Quantum Dot Probe for Smart Explosive Sensors
Authors: Parab Aniket A. , Karpe Aniket S. , Tiwari Anjali , Pattanaik Amitansu , Jadhav Yogesh , Walke Pravin , Chaskar Atul 
Published: August 2023

AbstractThe rapid detection of buried landmines has become a crucial concern of global security owing to the advancement in terrorist attacks. Indeed, the development of smart materials for the rapid detection of explosives especially nitro‐explosives is the need of time. However, the sensitivity and selectivity of materials for the detection of nitro‐explosives are major hurdles due to their low vapour pressure at room temperature. Albeit, it could be resolved by the use of advanced functional nanomaterials bearing high surface area and excellent optoelectronic properties. In this context, the water‐soluble MoS2 quantum dots (QDs) are synthesized by an ultrafast eco‐friendly hot injection method and potentially used for the detection of nitro‐explosives. The detection of picric acid (PA), 2,4,6‐Trinitrotoluene (TNT) and various other nitroaromatic compounds is performed by fluorescent probe technique. Notably, MoS2 QDs have effectively detected picric acid and TNT exhibiting detection limits of 5.13 ppm and 43.93 ppm respectively in water via a photoinduced electron transfer mechanism. Real‐time analysis of picric acid employing a paper strip of MoS2 QD as a fluorescent probe clearly demonstrates MoS2 QDs′ potential for practical usage in explosive detection. This work is patented: Application No. 202121000715 (applied).
Experimental and Computational Characterization of the Molecular Interaction between Bovine Serum Albumin and an Ester‐functionalized Cationic Gemini Surfactant
Authors: Lal Hira , Akram Mohd. , Kabir‐ud‐Din  
Published: August 2023

AbstractIn view of the recent emergence of surfactants as therapeutic agents for industrial‐based pharmacology, the current study highlights the critical aspects of a cationic C12−E2O2−C12 gemini surfactant, such as pharmacodynamics and pharmacokinetics. Surface tension, fluorescence and absorption studies reveal that the gemini surfactant interacts efficiently with the BSA. The Stern‐Volmer and Benesi‐Hildebrand equations, utilized to compute the binding constants (KSV and Kb), evaluated at three temperatures by utilizing fluorescence quenching data, provide evidence of static quenching and the evaluated thermodynamic parameters (which are all negative) suggest a spontaneous complexation with the pivotal role being played by both van der Waals forces and hydrogen bonds. Other complementary methods (3‐D, synchronous, RRS, CD, FT‐IR) confirmed conformational alterations in BSA due to the interaction. Binding of the C12−E2O2−C12 gemini surfactant within the protein's site I (sub‐domain IIA) had been derived from site probe and molecular docking analyses. Also, the HOMO‐LUMO energies, band gap energy and global reactivity descriptors of C12−E2O2−C12 gemini surfactant and the aromatic residues of BSA were evaluated. The study might help use C12−E2O2−C12, gemini surfactant as a therapeutic agent in the pharmaceutical industry.
Enhanced Electroreduction of Acetophenone Using Lipase Stabilization: Improved Conversion to 1‐Phenylethanol
Authors: Voigt Morgana Aline , Pinheiro Eduarda Boing , Zapp Eduardo , de Jesus Paulo César , Meier Lidiane , Curbani Luana , Bulegon Brondani Patrícia 
Published: August 2023

AbstractFew works present effective or viable alternatives to the problem of the electroreduction of acetophenone which usually leads to the pinacol dimer as a primary product in addition to 1‐phenylethanol. Here, various lipases were applied in acetophenone electroreduction. The optimized reaction conditions are tin/lead (63 : 37) combined working electrode coated with Nafion film modified with lipase from Thermomyces lanuginosus, a platinum counter electrode, applied potential of −2.0 V vs. Ag/AgCl (KCl 3.0 mol L−1), acetate buffer (0.1 mol L−1) pH 5.0 in 4 hours, and led to the formation of 87.8 % of 1‐phenylethanol. The same working electrode was used five times over five days, and the conversion remained constant. A voltammetric study indicates an alteration of the electroreduction mechanism in the presence of the cited lipase. Adding lipase from Thermomyces lanuginosus directly in the medium immobilized in a clay mineral or in silica gel (Lipolase 100T) resulted in even higher conversions (93.2–93.9 %). The modified electrode improved the methodology regarding enzyme stability, process reproducibility, and material reusability.
Comparison of serum 25(OH) vitamin D, parathormone and immunity marker concentrations between dogs with transmissible venereal tumour and healthy dogs
Authors: Sadeghian Helia Kamali , Mohri Mehrdad 
Published: August 2023

AbstractBackground1,25‐Dihydroxyvitamin D (1,25(OH)2 D) is vital in the homeostasis of calcium and bone health as well as in the prevention of many disorders such as neoplasms. Epidemiological data show that low concentrations of both 1,25(OH)2D and its precursor 25(OH) vitamin D (25(OH)D) are associated with an increased risk of a variety of human tumours.ObjectivesTo investigate 25(OH)D, parathormone (PTH) and immunity marker concentrations in dogs with transmissible venereal tumour (TVT).Methods25(OH)D, PTH and various biochemical and immunity markers were evaluated in dogs with TVT (n = 26) and in healthy (n = 30) dogs.Results25(OH)D concentrations were significantly lower in dogs with TVT in comparison with healthy dogs. In contrast, PTH, immunoglobulin G and interleukin (IL)‐9 concentrations were higher in the dogs with TVT. Other variables, including IL‐10, interferon γ, calcium and inorganic phosphate, were not statistically different between the two groups.ConclusionsDecreased serum 25(OH)D concentration may be a risk factor for the development of canine TVT; however, cause‐and‐effect remains incompletely understood. Further studies are required to elucidate the exact role of 25(OH)D in canine TVT and whether vitamin D supplementation may be useful prophylactically or as an adjunct to chemotherapy.
The initial steps toward the formation of somatic tissue banks and cell cultures derived from captive Antillean manatee (Trichechus manatus manatus) skin biopsies
Authors: Nascimento Matheus B. , Moura Yasmin B. F. , Oliveira Radan E. M. , Lira Gabriela P. O. , Borges Alana A. , Luna Fábia O. , Attademo Fernanda L. N. , Pereira Alexsandra F. 
Published: August 2023

AbstractThe declining population of the Antillean manatee caused by ecosystem degradation and rising pollution has prompted interest in developing conservation strategies for this species. Given this scenario, somatic tissue banks are important tools for acquiring knowledge about the species, as well as for obtaining somatic cells for biotechnological and ecotoxicological applications. Therefore, we aimed to assess the effects of slow freezing (SF) and solid‐surface vitrification (SSV) of the dermis of captive Antillean manatees on the histology and ultrastructure of the tissue and cell viability in culture. While the SSV did not change the dermis thickness, the SF maintained the tissue proliferative potential, assessed by the nucleolar organizer region area, similar to noncryopreserved tissues. Moreover, both techniques reduced the number of fibroblasts and increased the percentage of collagen fibers. Nevertheless, only tissues cryopreserved with SF and noncryopreserved tissues were able to produce cells after in vitro culture. Although SF did not alter cell viability and proliferative activity, cells derived from cryopreserved tissues showed decreased metabolism, altered apoptosis, increased levels of reactive oxygen species, and mitochondrial membrane potential compared to cells from noncryopreserved tissues. In summary, we demonstrated for the first time that Antillean manatee somatic tissues can be cryopreserved by SF, and cells can be obtained after in vitro culture. Improvements in cryopreservation conditions, especially vitrification, of somatic samples are needed to increase the quality of somatic tissue banks in this species.
The 3-dimensional Lyness map and a self-mirror log Calabi–Yau 3-fold
Authors: Ducat Tom 
Published: August 2023

AbstractThe 2-dimensional Lyness map is a 5-periodic birational map of the plane which may famously be resolved to give an automorphism of a log Calabi–Yau surface, given by the complement of an anticanonical pentagon of$$(-1)$$(-1)-curves in a del Pezzo surface of degree 5. This surface has many remarkable properties and, in particular, it is mirror to itself. We construct the 3-dimensional big brother of this surface by considering the 3-dimensional Lyness map, which is an 8-periodic birational map. The variety we obtain is a special (non-$${\mathbb {Q}}$$Q-factorial) affine Fano 3-fold of type$$V_{12}$$V12, and we show that it is a self-mirror log Calabi–Yau 3-fold.
Reliability of flow-cytometry in diagnosis and prognostic stratification of myelodysplastic syndromes: correlations with morphology and mutational profile
Authors: Guarnera Luca , Fabiani Emiliano , Attrotto Cristina , Hajrullaj Hajro , Cristiano Antonio , Latagliata Roberto , Fenu Susanna , Buccisano Francesco , Irno-Consalvo Maria , Conti Consuelo , Voso Maria Teresa , Maurillo Luca 
Published: August 2023

AbstractDiagnosis and prognostic stratification of myelodysplastic syndromes (MDS) have been complemented by new techniques, including flow cytometry and NGS. To analyze the relationship between molecular and cytofluorimetric data, we enrolled in this retrospective study, 145 patients, including 106 diagnosed with MDS and 39 controls. At disease onset, immunophenotypic (IF), cytogenetic tests, and cytomorphological (CM) examination on bone marrow were carried out in all patients, while NGS was performed in 58 cases. Ogata score presented a specificity of 100% and a sensitivity of 59%. The detection of at least two phenotypic aberrancies in Ogata negative patients increased the sensitivity to 83% and specificity to 87%. Correlations were identified between IF aberrancies and mutations, including positive Ogata>2 and mutations in SRSF2 (p=0.035), CD15 and U2AF1 (0.032), CD56 and DNMT3A (p=0.042), and CD38 and TP53 (p=0.026). In multivariate analysis, U2AF1 mutations, associated with del(20q) and/or abnormalities of chromosome 7 (group 4 as defined by the EuroMDS score), significantly correlated with an inferior overall survival (p=0.019). These parameters and Ogata score>2 also showed a significant correlation with inferior event-free survival (p=0.023 and p=0.041, respectively). Both CM and FC features correlated with prognosis and mutational patterns. In an integrated MDS work-up, these tools may guide indications for mutational screening for optimal risk stratification.
AML consolidation therapy: timing matters
Authors: Reimann Adrian-Manuel , Schalk Enrico , Jost Felix , Mougiakakos Dimitrios , Weber Daniela , Döhner Hartmut , Récher Christian , Dumas Pierre-Yves , Ditzhaus Marc , Fischer Thomas , Sager Sebastian 
Published: August 2023

Abstract
Purpose
Infections due to severe neutropenia are the most common therapy-associated causes of mortality in patients with acute myeloid leukemia (AML). New strategies to lessen the severity and duration of neutropenia are needed.

Methods
Cytarabine is commonly used for AML consolidation therapy; we compared high- and intermediate-dose cytarabine administration on days 1, 2, and 3 (AC-123) versus days 1, 3, and 5 (AC-135) in consolidation therapy of AML. Recently, clinical trials demonstrated that high-dose AC-123 resulted in a shortened white blood cell (WBC) recovery time compared with high-dose AC-135. Our main hypothesis is that this is also the case for different cytarabine dosage, granulocyte colony-stimulating factor (G-CSF) administration, and cycle lengths. We analyzed 334 treatment schedules on virtual cohorts of digital twins.

Results
Comparison of 32,565 simulated consolidation cycles resulted in a reduction in the WBC recovery time for AC-123 in 99.6% of the considered cycles (median reduction 3.5 days) without an increase in the number of leukemic blasts (lower value in 94.2% of all cycles), compared to AC-135.

Conclusion
Our numerical study supports the use of AC-123 plus G-CSF as standard conventional AML consolidation therapy to reduce the risk for life-threatening infectious complications.
Transferring the approach avoidance task into virtual reality: a study in patients with alcohol use disorder versus healthy controls
Authors: Ascone Leonie , Wirtz Janina , Mellentin Angelina Isabella , Kugler Dimitrij , Bremer Thomas , Schadow Friedrich , Hoppe Stine , Jebens Charlotte , Kühn Simone 
Published: August 2023

Abstract Study aims were to (I) transfer the measurement of the approach bias (Apb) related to alcoholic stimuli via the Approach Avoidance Task (AAT) into Virtual Reality (VR), (II) check whether measuring Apb in VR leads to similar or different results compared to the classical PC-based version, (III) check the validity of VR versus PC-based bias scores in terms of relatedness to clinical variables. Different ‘grasping-conditions’ were tested and contrasted in VR concerning (Ia) feasibility (performance): (1) never grasp, (2) always grasp, (3) grasp when PULLing stimuli towards oneself. (Ib) Differences in the bias scores between patients with alcohol use disorder (AUD) and healthy controls (HC) were examined for each grasping-condition. (II) PC-based bias scores were computed and contrasted for AUD versus HC. (III) Correlations of the different VR- versus PC-based bias scores with AUD symptom severity and impulsivity were checked to evaluate validity. (Ia) Grasping-condition 1, followed by 3, showed acceptable (> 50%) and good (> 80%) rates of correct performances allowing for robust median estimation. (Ib) Significant differences in the resulting bias scores emerged between AUD and HC only for grasping-condition 1 (p = 0.034) and 3 at trend-level (p = 0.093). For grasping-condition 1 the Apb Median for AUD was different from zero at a non-significant trend-level (p = 0.064). (II) The PC-based bias scores did not discriminate between AUD versus HC groups. (III) Grasping-condition 1 and 3 VR-based bias scores correlated significantly with impulsivity. In sum, transferring the AAT into VR is feasible, valid, and best implemented without an additional grasping-component when using the VR-controller. This way of Apb assessment represents a viable, perhaps even superior, alternative to PC-based assessments.Trial registration The trial was pre-registered at AsPredicted #76854: ‘Transferring the approach avoidance task into virtual reality’, 10/13/2021; prior to any analyses being undertaken.
Evaluation of PD-1 T lymphocytes in bronchoalveolar lavage in lung cancer compared to benign lung diseases
Authors: Hammer B. , Bal C. , Gysan M. , Zehetmayer S. , Geleff S. , Zech A. , Kramer M. , Ayazseven S. , Idzko M. , Mosleh B. , Hoda M. A. , Gompelmann D. 
Published: August 2023

AbstractThe expression of the programmed cell death protein 1 (PD-1) has been shown to be markedly increased in tumor-infiltrating lymphocytes. However, the proportion of PD-1 + T cells in the bronchoalveolar lavage (BAL) of lung cancer patients has not been sufficiently evaluated so far. In this prospective study, the proportion of PD-1 + CD4 + as well as PD-1 + CD8 + T cells in BAL samples, isolated from patients with lung cancer, asthma or interstitial lung disease (ILD), were determined via flow cytometry and compared for differences. Bronchoalveolar lavage was performed in 34 patients (14 patients with lung cancer, 10 patients with asthma, 10 patients with ILD). The highest median proportion of PD-1 + CD4 + or PD-1 + CD8 + T cells were found in patients with ILD (83.1% [IQR 72.1; 87.5] and 73.8% [IQR 60.3; 86.3]) followed by patients with lung cancer (66.4% [IQR 59; 69] and 77.1% [IQR 35.8; 82.3]) and patients with asthma (61.3% [IQR 57.4; 70.5] and 57.3% [IQR 46; 65]). Thereby, the difference in the proportion of PD-1 + CD3 + CD4 + BAL cells between ILD patients and asthmatics was significantly different (p = 0.04). The proportion of PD-1 + CD4 + and PD-1 + CD8 + T cells in the BAL of patients with lung cancer did not differ significantly to patients with benign lung diseases. The highest proportion was observed in ILD patients suggesting further research to evaluate the role of the PD-1/PD-L1 pathway in ILD patients.
The association of previous night's sleep duration with cognitive function among older adults: a pooled analysis of three Finnish cohorts
Authors: Teräs Tea , Myllyntausta Saana , Salminen Marika , Viikari Laura , Pahkala Katja , Muranen Olli , Hutri-Kähönen Nina , Raitakari Olli , Rovio Suvi , Stenholm Sari 
Published: August 2023

Abstract
Study objectives
Sleep duration has been shown to associate with cognitive function, but little is known about the short-term effect of sleep duration on the previous night. This study examines how usual sleep duration and previous night’s sleep duration are associated with cognitive function in older adults.

Methods
The study population consisted of 2949 adults aged 59–92 years (mean 72.6, SD 5.7) derived from three Finnish cohorts. Participants’ self-reported usual sleep duration was categorized into short (< 7 h, 19%), mid-range (7– < 9 h, 64%), and long (≥ 9 h, 17%). Self-reported sleep duration on the night prior to cognitive testing was categorized into shorter (59%), same (35%), and longer (5.9%) than usual sleep duration. Computerized Cambridge Neuropsychological Test Automated Battery (CANTAB®) was used to assess: (1) learning and memory, (2) working memory, (3) information processing, and (4) reaction time.

Results
Participants with self-reported long, but not short, usual sleep duration had poorer learning and memory (p = .004), information processing (p = .003), and reaction time (p = .006) when compared to those with mid-range sleep duration. Those who slept more than usually the night prior to cognitive testing had poorer information processing (p = .019) than those sleeping the same as usually, while sleeping less than usually was not associated with cognitive function.

Conclusions
This study suggests that while long sleep duration was associated with worse cognitive function, sleeping more than usually the night prior to cognitive testing was only associated with information processing, and sleeping less than usually is not associated with cognitive function.
Findings from an Organizational Context Survey to Inform the Implementation of a Collaborative Care Study for Co-occurring Disorders
Authors: Evans Sandra K. , Dopp Alex , Meredith Lisa S. , Ober Allison J. , Osilla Karen C. , Komaromy Miriam , Watkins Katherine E. 
Published: August 2023

AbstractPrimary care is an opportune setting to deliver treatments for co-occurring substance use and mental health disorders; however, treatment delivery can be challenging due multi-level implementation barriers. Documenting organizational context can provide insight into implementation barriers and the adaptation of new processes into usual care workflows. This study surveyed primary care and behavioral health staff from 13 clinics implementing a collaborative care intervention for opioid use disorders co-occurring with PTSD and/or depression as part of a multisite randomized controlled trial. A total of 323 completed an online survey for a 60% response rate. The Consolidated Framework for Implementation Research guided this assessment of multi-level factors that influence implementation. Most areas for improvement focused on inner setting (organizational level) constructs whereas individual-level constructs tended to be strengths. This work addresses a research gap regarding how organizational analyses can be used prior to implementation and provides practical implications for researchers and clinic leaders.
Temporal bone CT-based anatomical parameters associated with the development of cholesteatoma
Authors: Cavaliere Michele , Ugga Lorenzo , Monfregola Armando , Cavaliere Fabrizia , Caranci Ferdinando , Russo Carmela , Briganti Francesco , Elefante Andrea 
Published: August 2023

Abstract
Background
Cholesteatoma is caused by disorders of the middle ear ventilation that trigger a progressive series of events responsible for its formation. The aim of this study was to identify possible radiological CT-derived parameters predisposing to ventilation disorders and cholesteatoma.

Methods
In this retrospective study, patients diagnosed with cholesteatomatous chronic otitis media who underwent temporal bone CT and open tympanoplasty surgery have been included, as well as control patients with clinical examination negative for organic otological pathology who underwent temporal bone CT for other reasons. For each patient, the following parameters have been extracted from CT volumes: degree of mastoid pneumatization, prominence of the cog, patency of the Eustachian tube, antrum width, aditus width, anterior and posterior epitympanic widths, and epitympanic height.

Results
Sixty patients have been included, thirty of whom belonged to the group of patients with cholesteatoma and the remaining part to the group of patients without organic otological pathology. The prevalence of a low degree of mastoid pneumatization was significantly higher among patients with cholesteatoma, as well as for the prevalence of cog prominence (p < 0.001). All the continuous variables were found to have statistical significance (p < 0.05) in the comparison between groups except for the width of the antrum.

Conclusion
Mastoid pneumatization degree, prominence of the cog and epitympanic measures based on temporal bone CT could be good radiological correlates of the ventilatory capabilities of the epitympanum which, if compromised, can facilitate the development of cholesteatoma.