bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR‐32533 Reduces Cognitive Impairment and Amyloid‐β Overload by Targeting CREB5‐Mediated Signaling Pathways in Alzheimer's Disease
Authors: Zeng Li , Cai Zhongdi , Liu Jianghong , Zhao Kaiyue , Liang Furu , Sun Ting , Li Zhuorong , Liu Rui 
Published: January 2025

AbstractMicroRNAs (miRNAs) are associated with amyloid‐β (Aβ) dysmetabolism, a pivotal factor in the pathogenesis of Alzheimer's disease (AD). This study unveiled a novel miRNA, microRNA‐32533 (miR‐32533), featuring a distinctive base sequence identified through RNA sequencing of the APPswe/PSEN1dE9 (APP/PS1) mouse brain. Its role and underlying mechanisms were subsequently explored. Bioinformatics and confirmatory experiments revealed that miR‐32533 had a novel 23‐base sequence with minimal coding potential, functioning within the Drosha ribonuclease III (Drosha)/Dicer 1, ribonuclease III (Dicer)‐dependent canonical pathway and identifiable via northern blot. miR‐32533 was abundantly brain‐distributed and downregulated in diverse AD‐related models, including APP/PS1 and five familial AD (5×FAD) mouse brains and AD patient plasma. Overexpression or inhibition of miR‐32533 led to improvements or exacerbations in cognitive dysfunction, respectively, by modulating Aβ production, apoptosis, oxidation, and neuroinflammation through targeting cAMP‐responsive element binding protein 5 (CREB5), which interacted with α disintegrin and metalloproteinase 10 (ADAM10), beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1), and presenilin 1 (PS1) promoters, thereby enhancing Aβ production through BACE1 and PS1 upregulation while suppressing non‐amyloidogenic amyloid precursor protein (APP) processing via ADAM10 downregulation. Furthermore, modulation of the miR‐32533/CREB5 axis ameliorated or worsened cognitive impairment by inhibiting or amplifying Aβ overproduction through the BACE1‐involved amyloidogenic and ADAM10‐involved non‐amyloidogenic pathways. Overall, the findings suggest miR‐32533 as a regulator of Aβ metabolism, oxidative stress, and neuroinflammation, establishing the miR‐32533/CREB5 signaling pathways as potential therapeutic targets for combating Aβ accumulation and cognitive deficits in AD.
All‐Optical Modulation Photodetectors Based on the CdS/Graphene/Ge Sandwich Structures for Integrated Sensing‐Computing
Authors: Yang Qi , Hu Jie , Li Haozhou , Du Qing , Feng Shuanglong , Yang Dong , Zhang Yupeng , Shen Jun 
Published: January 2025

AbstractIn this manuscript, an all‐optical modulation photodetector based on a CdS/graphene/Ge sandwich structure is designed. In the presence of the modulation (near‐infrared) light, the Fermi level of the graphene channel shifts, allowing for the tuning of the visible light response speed as well as achieving a broad responsivity range from negative (‐3376 A/W) to positive (3584 A/W) response. Based on this, logical operations are performed by adjusting the power of the modulation light superimposed with the signal light. This facilitates more covert, all‐optical, high‐speed encrypted communication. The ultrahigh tunability and nearly symmetric positive and negative photoconductivity of all‐optical modulation photodetectors significantly enhance the computational capacity of neuromorphic hardware. The proposed device exhibits substantial advantages in applications requiring high fault tolerance for integrated sensing‐computing （ISC） and high‐resolution motion object recognition, providing insights for the development of next‐generation high‐bandwidth, low‐power‐consumption ISC devices.
Thyroid‐Targeted Nano‐Bombs Empower HIFU for Graves' Disease
Authors: Wang Binhao , Yin Zhuobing , You Xiangyue , Peng Hanwei , Jiang Ying 
Published: January 2025

AbstractGraves' disease (GD) is an autoimmune disorder with a high incidence rate, particularly affecting women of reproductive age. Current treatment modalities for GD carry significant disadvantages, especially for pregnant or nursing women. As a novel extracorporeal therapeutic technique, high‐intensity focused ultrasound (HIFU) shows great promise for treating GD; however, its low treatment efficacy impedes clinical application. In this study, a thyroid‐targeted nano‐bomb system (PD‐PLGA@Si‐Ab/PDA‐I, PSAPI) is developed to enhance HIFU efficacy and improve therapeutic outcomes for GD. The core structure of PSAPI encapsulates a phase‐transition material, perfluorohexane, and the anti‐inflammatory drug diclofenac within a poly(lactide‐co‐glycolide) (PLGA) and silica shell. A polydopamine coating enhances biocompatibility, while iodine loading and thyroid‐stimulating hormone receptor (TSHR) antibodies grafting ensure targeted delivery to the thyroid. Robust in vitro and in vivo results demonstrated that PSAPI is highly biocompatible, accumulates in the thyroid within 24 h after administration, and significantly potentiates the therapeutic efficacy of HIFU, resulting in markedly reduced inflammatory responses. Transcriptomic analysis revealed a cellular defense mechanism activated in PSAPI‐treated cells following HIFU irradiation, highlighting potential molecular targets for the future development of HIFU‐sensitizing agents. The biocompatible PSAPI nano‐bomb developed in this study holds great transformative potential, addressing critical gaps in current therapeutic practices for GD.
Unraveling Redox Mediator‐Assisted Chemical Relithiation Mechanism for Direct Recycling of Spent Ni‐Rich Layered Cathode Materials
Authors: Kim Suji , Shin Ukseon , Yoon Hyun Ju , Yoon Soo‐Ah , Song Jinju , Ma Jiyoung , Woo Jung‐Je , Nam Kyung‐Wan , Seo Dong‐Hwa , Ryu Won‐Hee 
Published: January 2025

AbstractThe increasing demand for Li‐ion batteries across various energy storage applications underscores the urgent need for environmentally friendly and efficient direct recycling strategies to address the issue of substantial cathode waste. Diverse reducing agents for Li supplements, such as quinone molecules, have been considered to homogenize the Li distribution in the cathode materials obtained after cycling; however, the detailed reaction mechanism is still unknown. Herein, the ideal electrochemical potential factor and reaction mechanism of the redox mediator 3,5‐di‐tert‐butyl‐o‐benzoquinone (DTBQ) for the chemical relithiation of high‐Ni‐layered cathodes are elucidated. Here, 100% efficiency of DTBQ‐assisted chemical relithiation is achieved by adjusting the direct immersion time of Li‐deficient cathode electrodes. The reversible reaction features of the physical and chemical structures of both the regenerated cathodes and the DTBQ molecules are investigated using advanced characterization and density functional theory calculations. These findings emphasize the potential of redox‐mediator‐assisted chemical relithiation for realizing direct recycling processes and offer a facile and sustainable solution for battery recycling.
Functionalized Interlayers in Self‐Powered Organic Photodiodes for Enhanced Near‐Infrared Sensing
Authors: Lee Yongju , Biswas Swarup , Nam Dong Hyun , Park Jae Won , Jang Hyowon , Choi Hyojeong , Kim Juhwan , Park Dong‐Wook , Kim Hyeok 
Published: January 2025

AbstractThere is a growing interest in fabricated organic material‐based photodiodes (OPDs) since they are lightweight, flexible, and cost‐effective to manufacture. Notably, they exhibit near‐infrared photo‐sensing capabilities that are self‐powered, a feature attributed to the tunable optical properties of organic semiconductor (OSC) materials. Nonetheless, the application of OPDs in the semiconductor industry encounters challenges compared to their inorganic counterparts, such as low sensitivity and limited durability. In this study, a self‐powered OPD using a poly[4,8‐bis(5‐(2‐ethylhexyl)thiophen‐2‐yl)benzo [1,2‐b:4,5‐b′]dithiophene‐2,6‐diyl‐alt‐(4‐(2‐ethylhexyl)‐3‐fluorothieno[3,4‐b]thiophene‐)‐2‐carboxylate‐2‐6‐diyl)]:biaxial active layer of phenyl‐C70‐butyric acid methyl ester (PTB7‐Th:PC70BM) and an organic hole transport layer (HTL) composed of poly(3,4‐ethylenedioxythiophene) and poly(styrene sulfonate) (PPY:PSS) is developed. These results highlight the effectiveness of PPY:PSS as an HTL, demonstrating distinct improvements in efficiency, photosensitivity, photo‐detectivity, and operational stability of the OPD when the weight ratio between the PPY and PSS is 1:2.
Concurrent Operando Neutron Imaging and Diffraction Analysis Revealing Spatial Lithiation Phase Evolution in an Ultra‐Thick Graphite Electrode
Authors: Strobl Markus , Baur Monica E. , Samothrakitis Stavros , Malamud Florencia , Zhang Xiaolong , Tung Patrick K.M. , Schmidt Søren , Woracek Robin , Lee Jongmin , Kiyanagi Ryoji , Kuhn Luise Theil , Gavish Segev Inbal , Ein‐Eli Yair 
Published: January 2025

AbstractEnergy‐efficient, safe, and reliable Li‐ion batteries (LIBs) are required for a wide range of applications. The introduction of ultra‐thick graphite anodes, desired for high energy densities, meets limitations in internal electrode transport properties, leading to detrimental consequences. Yet, there is a lack of experimental tools capable of providing a complete view of local processes. Here, a multi‐modal operando measurement approach is introduced, enabling quantitative spatio‐temporal observations of Li concentrations and intercalation phases in ultra‐thick graphite electrodes. Neutron imaging and diffraction concurrently provide correlated multiscale information from the scale of the cell down to the crystallographic scale. In particular, the evolving formation of the solid electrolyte interphase (SEI), observation of gradients in total lithium content, as well as in the formation of ordered LixC6 phases and trapped lithium are mapped throughout the first charge–discharge cycle of the cell. Different lithiation stages co‐exist during charging and discharging; delayed lithiation and delithiation processes are observed in central regions of the electrode, while the SEI formation, potential plating, and dead lithium are predominantly found closer to the interface with the separator. The study emphasizes the potential to investigate Li‐ion diffusion and the kinetics of lithiation phase formation in thick electrodes.
Host–Guest Complexation of α‐Cyclodextrin and Triiodide Ions for Enhanced Performance of Ionic Thermoelectric Capacitors
Authors: Kao Shih‐Ting , Hsu Ching‐Chieh , Hong Shao‐Huan , Jeng U‐Ser , Wang Chia‐Hsin , Tung Shih‐Huang , Liu Cheng‐Liang 
Published: January 2025

AbstractIonic thermoelectric materials have emerged as a promising avenue for harvesting low‐grade waste heat, with significant potential for applications in wearable electronics. This study introduces a novel design for ionic thermoelectric capacitors (ITECs) by incorporating host–guest complexation between α–cyclodextrin (α‐CD) and triiodide ions (I3−). The strong host–guest complexation between α‐CD and I3− confines the diffusion of I3− within the cylindrical cavities of α‐CD, as evidenced by UV–vis spectroscopy and 13C‐NMR analysis. This confinement enhances the ion mobility difference between I3− and sodium ions, which in turn significantly boosts the ionic thermopower of the polyvinyl alcohol/α‐CD/NaI hydrogels. Accordingly, the optimized sample achieves an impressive positive ionic thermopower of 14.24 mV K−1 and a high ionic power factor of 477.2 µW K−2 m−1. Furthermore, the stretchable ITEC demonstrates a substantial power density of 5.9 mW m−2. When integrated into a 3‐leg device, a stable thermovoltage of 176 mV is generated under a temperature gradient of 4.4 K, thus highlighting the potential of this system for efficient thermal energy harvesting.
Functional Alloy Collector Capable of Sustainable Lithium Compensation for Anode‐Free Batteries by a Controlled Lithium‐Prestorage Technology
Authors: Liu Yao , Zeng Cheng , Hu Mingtao , Liang Haoyue , Wei Xinqi , Ji Xinyu , Wang Shuhao , Liu Xizheng , Cui Yanming , Lin Jiu , Zhai Tianyou , Li Huiqiao 
Published: January 2025

AbstractWith higher energy density and reduced cost, anode‐free battery has attracted great attention from both academic and industry. However, the development of anode‐free batteries is hindered by their poor cycle life due to the continuous irreversible lithium (Li) consumption at the anode side. Here, a surface‐functionalized alloy foil, which can gradually release active lithium to the cell upon cycling, used as the collector for anode‐free batteries is proposed. The alloy foil is prestored with a certain amount of active lithium via a simple wet contacting reaction between the metal foil and liquid lithium source reagent. The prestored lithium amount can be precisely controlled by reagent concentration and contact time. When the foil is used as the anode, its alloyed surface demonstrates a low nucleation barrier for lithium deposition and a more uniform deposition behavior. More importantly, the alloy collector can rationally release active lithium to sustainably compensate for the irreversible Li consumption upon the cycling of a full cell, thus greatly prolonging the cycle life of the anode‐free battery by 10 times. Besides, this technique can be extended to diverse metal collectors demonstrating its broad applicability.
Phase Transition Behavior During Sintering Process of Li‐Rich Materials
Authors: Zhang Mengke , Li Jiayang , Pang Qi , Hua Weibo , Deng Yuting , Tang Manqi , Pang Weikong , Wu Zhenguo , Zhong Benhe , Xiao Yao , Qiu Lang , Guo Xiaodong 
Published: January 2025

AbstractPhase transition serves as an ordinary behavior occurring during the high‐temperature calcination process, while it becomes quite complicated in Li‐rich materials composed of rhombohedral phase LiTMO2 (TM: Ni, Mn) with Rm space group and monoclinic phase Li2TMO3 with C2/m space group. Yet to be firmly elucidated is how the precursor transforms into LiTMO2 (Rm)‐Li2TMO3 (C2/m) compound and what is the precise conversion mechanism between these two phases. This work systematically elaborates the structural evolution with Li/O incorporation during calcination, and proposes a LiTMO2 to Li2TMO3 phase transition mechanism. A series of characterizations on structural rearrangement and detailed analysis provide insights into the comprehension of this transition, i.e., the transition metal (TM) vacancies induced by interlayer TM ions migration function as the primary reason driving the transformation from LiTMO2 to Li2TMO3. This work offers a novel concept for the structural regulation in Li‐rich cathodes.
New AIE Emitters from the Unexpected Boron Tribromide/Boron Trichloride‐mediated Cyclization Reaction and Application for Fluorescence Imaging of Lipid Droplets
Authors: Hu Yichen , Gao Xin , Ma Junlong , Shangguan Zhichun , Chen Liangliang , Zhang Guanxin , Zhang Xi‐Sha , Li Cheng , Li Yanbang , Zhang Deqing 
Published: January 2025

ABSTRACTThe aberrant behavior of lipid droplets (LDs) is often indicative of cellular dysfunction, which may contribute to the development of a range of diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and atherosclerosis (AS). Consequently, there is an urgent need to develop fluorescence probes targeting LDs to monitor the progression of disease. In this study, an unanticipated one‐pot boron tribromide (BBr₃)/boron trichloride (BCl₃)‐promoted cyclization reaction was discovered, yielding a bromo‐/chloro‐substituted triphenylamine (TPA) derivative (TPA‐Br/TPA‐Cl). TPA‐Br was successfully transformed into new TPA‐containing donor‐acceptor (D–A) molecules which show typical aggregation induced emission (AIE) property. Among these new AIE emitters, TPA‐N shows the most promising LDs targeting specificity, lowest toxicity and best photo‐stability. Ex vivo studies further demonstrate that TPA‐N can be used to fluorescence image fatty liver and AS plaque quickly and effectively.
Caring for the mental health of Afghan refugee youth through a decolonial paradigm: A qualitative analysis of distress, coping mechanisms, and priorities for treatment
Authors: Hosseini Zainab , Alucozai Doonyah , Ahmad Sadena , Omid Mahmood , Khatib Zainab , Mansouri Moones , Awaad Rania 
Published: January 2025

AbstractDespite the compounded adversities that displaced youth must navigate throughout their forced migration, they consistently exhibit steadfastness in caring for themselves and their families. Extant scholarship, however, often frames these individuals as needy and inept at informing the models of mental health care they are offered. In this study, we use semistructured interviews to learn from the experiences of Afghan refugee youth (N = 34; M age = 19; range 18–24) who were resettled in the United States after the United States withdrawal from Afghanistan in August of 2021 and explore their insights that can inform decolonial and equitable mental health services. Specifically, we elucidate their most salient sources of psychological distress, current coping mechanisms, and priorities for treatment, with a specific focus on the unique experiences of accompanied versus unaccompanied youth. Unaccompanied youth reported more frequent and intense sources of distress, including pre‐resettlement (e.g., exposure to life‐threatening sociopolitical conflicts) and post‐resettlement challenges (e.g., limited access to basic resources and legal status precarity). Youth used faith‐based, relationship‐based, and ethnocultural‐based mechanisms of coping. While 62% of participants reported doubts about the usefulness of mental health care, most of those who expressed an openness to treatment prioritized clinicians who have personal experience in navigating common challenges among refugees. We situate these findings within decolonial and intersectional theoretical frameworks that capture the nuances of Afghan refugee experiences and offer recommendations for ensuring refugee youth's rights to access equitable mental health services.
Combination of Biological Aging and Genetic Susceptibility Helps Identifying At‐Risk Population of Venous Thromboembolism: A Prospective Cohort Study of 394 041 Participants
Authors: Hu Zhensheng , Xu Jiatang , Shen Runnan , Lin Liling , Su Yangfan , Xie Chaoyu , You Guochang , Zhou Yi , Huang Kai 
Published: January 2025

ABSTRACTPhenotypic age acceleration (PhenoAgeAccel) is a novel clinical aging indicator. This study was carried out to investigate the relationship between PhenoAgeAccel and the incidence of VTE, as well as to integrate PhenoAgeAccel with genetic susceptibility to improve risk stratification of VTE. The study included 394 041 individuals from the UK Biobank. Phenotypic age was calculated based on actual age and clinical biomarkers. PhenoAgeAccel presents the residual obtained from a linear regression of phenotypic age against actual age, reflecting the rate of aging. Significant associations were observed between PhenoAgeAccel and higher risk of VTE (Hazard ratio [HR] 1.37, 95% CI: 1.32–1.42), deep vein thrombosis (DVT, HR 1.35, 95% CI: 1.29–1.42), and PE (pulmonary embolism, HR 1.41, 95% CI: 1.34–1.48) in the findings. PhenoAgeAccel exhibited a significant additive interaction with genetic susceptibility. Biologically older participants with high genetic risk have a 3.83 (95% CI: 3.51–4.18) folds risk of VTE, a 3.59 (95% CI: 3.21–4.03) folds risk of DVT, and 4.39 (95% CI: 3.88–4.98) folds risk of PE, in comparison to biologically younger participants with low genetic risk. Mediation analyses indicated that PhenoAgeAccel mediated approximately 6% of the association between cancer and VTE, and about 20% of the association between obesity and VTE. Our study indicated that PhenoAgeAccel is significantly associated with higher risk of VTE, and can be combined with genetic risk to improve VTE risk stratification. Additionally, PhenoAgeAccel holds promise as a clinical biomarker for guiding targeted prevention and treatment strategies for VTE.
Development and Evaluation of Thermosensitive Hydrogels for Hydrogen Sulfide Gas Release: A Novel Approach for Therapeutic Applications
Authors: Phan Hai Nam , Nguyen Huyen Thanh Anh , Nguyen Luan Minh , Nguyen Dai Hai , Tran Dieu Linh 
Published: January 2025

ABSTRACTHydrogen sulfide (H₂S) plays a critical role in regulating various pathological processes, such as protecting cells from injury and promoting tissue regeneration, making it a focus of therapeutic applications. However, the unpredictable release of H₂S donors limit its clinical use. In this study, a novel delivery system was developed by encapsulating 5‐aminopyridine‐2‐thiocarboxamide (APTC), a small‐molecule H₂S donor, into a gelatin‐Pluronic (GP) thermosensitive hydrogel. The GP hydrogel exhibited excellent thermosensitivity, transitioning from sol to gel at physiological temperature (~37°C) while maintaining its gelling temperature upon APTC addition, making it ideal for minimally invasive applications. The methylene blue assay demonstrated controlled H₂S release, with the highest cumulative release (1.2 mM) at 80 h in the GP‐APTC 15 hydrogel. Cytocompatibility and cell behavior studies using HUVECs showed that H₂S release significantly enhanced cell migration, fully covering scratched areas within 24 h. GP‐APTC hydrogels also promoted angiogenesis, evidenced by in vitro tube formation and in ovo CAM assays, with greater APTC concentrations leading to increased tube branching and denser vascular networks. This study highlights the novelty of using a thermosensitive GP‐APTC hydrogel as a controlled H₂S delivery platform, offering significant potential for various therapeutic applications, including tissue regeneration and wound healing.
Ground Tire Rubber/Polypropylene Compounds: Relationship Between Physicochemical and Mechanical Properties
Authors: Flores‐Silva Pamela Celeste , Quintanar‐Hernández Rocío , Sifuentes‐Nieves Israel , Sánchez‐Valdés Saúl , González‐Morones Pablo , Hernández‐García Zureima , Hernández‐Hernández Ernesto , Hernández‐Gámez José Francisco 
Published: January 2025

ABSTRACTA dual acetone‐ultrasound treatment was employed to devulcanize ground tire rubber, which was then used to prepare polypropylene/GTR composites by melt processing. The effect of the type of GTR (acetone treatment and acetone‐ultrasound treatment) and the content incorporated (10, 20, 30, 40, and 50 wt%) on the melt flow and mechanical properties of reprocessed PP was studied. The TGA results showed a decrease in the content of the additives in the treated GTR, improving the interactions with the polymer matrix as indicated by MFI, FTIR, and tensile modulus. The results showed that acetone‐ultrasound‐treated GTR could produce PP extruded pipes for outdoor wire protection, an application that may interest construction industries.
Green Recovery of Toxic Prussian White Cathode From Spent All‐Climate Sodium‐Ion Batteries Using Low‐Melting Mixture Solvents (LoMMSs)
Authors: Chen Yu , Zhao Mengxi , Chen Jiaxin , Dong Jiayi , Niu Zihang , Wang Taoran , Wang Chenyang , Zhang Yuqing 
Published: January 2025

ABSTRACTA large number of spent sodium‐ion batteries (SIBs) will be produced as SIBs become more widely used. However, components of spent SIBs, such as the cathode Prussian white Na2Mn[Fe(CN)6], are toxic and hazardous, leading to water and soil pollution and posing a threat to human health. Therefore, recycling spent SIBs cathode is important and meaningful. Here, we use phytic acid‐based low‐melting mixture solvents (LoMMSs) for the efficient recovery of toxic and hazardous SIBs cathode Prussian white at mild temperatures. Results show that the highest Na leaching efficiency from Prussian white could reach 94.7% by polyethylene glycol 200:phytic acid (14:1) at 80°C for 24 h with a liquid/solid ratio of 50:1. Furthermore, the metal extracted from the leachate is found to precipitate when water is used as the anti‐solvent, with ammonium hydroxide achieving the highest precipitation efficiency of 89.3% at room temperature.