bluuebunny/crossref_metadata_2025_split huggingface dataset:
(550) Sexual Arousal in Premenopausal Breast Cancer Patients on Antihormonal Treatment
Authors: Grosse-Rueschkamp M S , Kronthaler S M , Friedrich M , Oesterling C F , Beier K M , Hatzler L 
Published: May 2023

Abstract

Introduction
Breast Cancer is the most common cancer in women and is associated with a severe impairment of general life quality, body-related self-esteem and sexual function and satisfaction. Sexual satisfaction has been shown to have a significant impact on general health and well-being. Nevertheless, research aiming at understanding sexual function in breast cancer patients is very scarce, no vaginal plethysmography data measuring vaginal blood flow on breast cancer patients currently exists. A better understanding of the interplay of the physiological sexual response and subjective sexual arousal in breast cancer survivors could help develop new strategies for treating this specific target group and contributing to improve their health and life quality.

Objective
The aim of this study is to collect preliminary data on psychophysiological aspects of the sex.al function of premenopausal breast cancer patients on antihormonal therapy and compare them with healthy controls. Specifically, we hypothesized that (1) genital arousal following visual stimuli is less in breast cancer patients than in healthy controls, (2) genital arousal following tactile stimuli is the same in breast cancer patients and healthy controls, (3) genital arousal following tactile stimuli is greater than following visual stimuli in both breast cancer patients and healthy controls. Serum sex hormone levels and self-reported sexual function are analyzed as moderators.

Methods
Breast cancer survivors (n=60) treated with antihormonal therapy for breast cancer, who are in complete remission for at least one year and healthy controls (n=20), undergo vaginal plethysmography while sexual stimuli (visual, tactile, visual + tactile) are presented. Subjective arousal and genital arousal are recorded continuously. Hormone serum levels, self-reported sexual function, sexual self-esteem, and quality of life measures are analyzed as potential moderators.

Results
Intraindividual differences (subjective and genital arousal) and interindividual differences (breast cancer patients, healthy controls) are analyzed based on a 2-level mixed effect models for each outcome variable. Pearson correlations are calculated to assess the relationships between subjective arousal and genital arousal for each group.

Conclusions
This study is the first to provide data on genital and subjective arousal in premenopausal women with breast cancer on antihormonal treatment compared to healthy controls and explore the data in connection with serum hormone levels. Overall, it will give a further insight in sexual function of breast cancer survivors to reveal targets to improve sexual function in this target group.

Disclosure
Yes, this is sponsored by industry/sponsor: WOW Tech™ Group.

Clarification
Industry funding only - investigator initiated and executed study.
Measurement of parity-odd modes in the large-scale 4-point correlation function of Sloan Digital Sky Survey Baryon Oscillation Spectroscopic Survey twelfth data release CMASS and LOWZ galaxies
Authors: Hou Jiamin , Slepian Zachary , Cahn Robert N 
Published: May 2023

ABSTRACTA tetrahedron is the simplest shape that cannot be rotated into its mirror image in three-dimension (3D). The 4-point correlation function (4PCF), which quantifies excess clustering of quartets of galaxies over random, is the lowest order statistic sensitive to parity violation. Each galaxy defines one vertex of the tetrahedron. Parity-odd modes of the 4PCF probe an imbalance between tetrahedra and their mirror images. We measure these modes from the largest currently available spectroscopic samples, the 280 067 luminous red galaxies (LRGs) of the Baryon Oscillation Spectroscopic Survey (BOSS) twelfth data release (DR12) LOWZ ($\bar{z} = 0.32$ ) and the 803 112 LRGs of BOSS DR12 CMASS ($\bar{z} = 0.57$ ). In LOWZ, we find 3.1σ evidence for a non-zero parity-odd 4PCF, and in CMASS we detect a parity-odd 4PCF at 7.1σ. Gravitational evolution alone does not produce this effect; parity-breaking in LSS, if cosmological in origin, must stem from the epoch of inflation. We have explored many sources of systematic error and found none that can produce a spurious parity-odd signal sufficient to explain our result. Underestimation of the noise could also lead to a spurious detection. Our reported significances presume that the mock catalogues used to calculate the covariance sufficiently capture the covariance of the true data. We have performed numerous tests to explore this issue. The odd-parity 4PCF opens a new avenue for probing new forces during the epoch of inflation with 3D large-scale structure; such exploration is timely given large upcoming spectroscopic samples such as Dark Energy Spectroscopic Instrument and Euclid.
TRIPBASE: a database for identifying the human genomic DNA and lncRNA triplexes
Authors: Lin Tzu-Chieh , Liu Yen-Ling , Liu Yu-Ting , Liu Wan-Hsin , Liu Zong-Yan , Chang Kai-Li , Chang Chin-Yao , Ni Hung Chih , Huang Jia-Hsin , Tsai Huai-Kuang 
Published: May 2023

Abstract
Long-non-coding RNAs (lncRNAs) are defined as RNA sequences which are &gt;200 nt with no coding capacity. These lncRNAs participate in various biological mechanisms, and are widely abundant in a diversity of species. There is well-documented evidence that lncRNAs can interact with genomic DNAs by forming triple helices (triplexes). Previously, several computational methods have been designed based on the Hoogsteen base-pair rule to find theoretical RNA–DNA:DNA triplexes. While powerful, these methods suffer from a high false-positive rate between the predicted triplexes and the biological experiments. To address this issue, we first collected the experimental data of genomic RNA-DNA triplexes from antisense oligonucleotide (ASO)-mediated capture assays and used Triplexator, the most widely used tool for lncRNA–DNA interaction, to reveal the intrinsic information on true triplex binding potential. Based on the analysis, we proposed six computational attributes as filters to improve the in-silico triplex prediction by removing most false positives. Further, we have built a new database, TRIPBASE, as the first comprehensive collection of genome-wide triplex predictions of human lncRNAs. In TRIPBASE, the user interface allows scientists to apply customized filtering criteria to access the potential triplexes of human lncRNAs in the cis-regulatory regions of the human genome. TRIPBASE can be accessed at https://tripbase.iis.sinica.edu.tw/.
Consumer (Rights) Movements in Latin America
Authors: Rhodes Sybil 
Published: May 2023

Abstract
This chapter outlines the history of scholarship on consumption and consumer mobilization in Latin America. Three “generations” of writers (defined by the chronological and thematic focus of their studies but also somewhat by the timing and sequence of their work) have made original contributions drawn from the context of the region to broader, and interdisciplinary, academic debates. The first generation argued that “irrational” consumer behavior often has a negative impact on economic development. A second generation produced empirical studies of the evolution of consumers’ legal rights, especially in the larger and wealthier countries of the region. A major finding of the second generation is that social and political mobilization in favor of consumer rights is more common in political democracies with market economies. A third generation of scholarship has emphasized the importance of consumerism for expressing identity, especially but not limited to gender, and new values, particularly environmentalism, and working conditions and other ethical issues along the production chain. Recent developments such as social media, internet shopping, and big data-based consumer analytics present challenges that are only beginning to be analyzed from multiple disciplinary angles. Among Latin American scholars, consumption differences between haves and have-nots remain as a fundamental tension.
Experimental Archaeology Enables Inferences about Human Cognition
Authors: Wadley Lyn 
Published: May 2023

Abstract
Proxies derived from commonplace technology that was used in the Palaeolithic can be used to identify sophisticated human cognition because some procedures cannot be accomplished without specific cognitive attributes. Complex cognition like that of modern people can be inferred from components of technical processes that cannot be undertaken without cognitive attributes such as switching attention between actions, analogical reasoning, delayed gratification, and multi-tasking. Experiments to replicate everyday tasks performed in the past can thus provide insights into the minds of people who lived many thousands of years ago. Furthermore, experiments can provide a form of bridging theory between archaeological data and the interpretation of the cognitive abilities of people in the past. Control of fire, in particular, sets human tasks apart from technology used by other primates. Fire has been used, for example, in actualistic adhesive manufacture and for heat treatment of rocks and minerals to improve their flaking properties. While several cognitive attributes are required for both of these everyday tasks, adhesive production particularly requires planning and multitasking, while heat treatment involves analogical reasoning when rocks are buried under a fire.
Hominin Stone Tool Manufacture
Authors: Moore Mark W. 
Published: May 2023

Abstract
The process of controlled stone flaking is tightly constrained by the mechanics of fracture. The stone progressively shrinks during flaking and, as mass is removed, cannot return to its prior state. Modern flintknappers use their forward-planning abilities to work within these design space parameters to produce highly complex tools. Forward-planning abilities must have emerged at some point in hominin evolution, but it is unwarranted to project modern human stone-flaking strategies onto our earliest hominin ancestors. To avoid a reliance on the unconstrained actions of modern flintknappers, an experimental research program was designed that restricted a modern flintknapper in a way that mimicked cognitively simple stone-flaking behaviors of early hominins. The experiments were based on a design space model that parsed stone flaking into its constituent parts, called flake units, and hypothesized that it is possible to create ostensibly complex stone tools without invoking advanced forward-planning abilities; these stone tools are called “spandrels.” The experiments involved using a random number generator to disrupt a modern flintknapper’s propensity to plan, thus creating an assemblage that did not refer to an internal representation or mental template. Nevertheless, the spandrels included bifacial cores, handaxes, and Levallois-like cores and flakes. This challenges the dominant tool-based narratives of early hominin cognitive evolution, which infer that these techniques and tool types are proxies of advanced cognition. Experimental research into stone-flaking design space, combined with better theoretical understanding of the scope offered by that design space, offers an epistemologically robust avenue for evaluating the evolution of hominin cognitive abilities from stone tools.
Coalescence and Transcendence
Authors: Wragg Sykes Rebecca 
Published: May 2023

Abstract
The past two decades have witnessed a dramatic shift in evidence for composite objects and adhesive manufacture in the Palaeolithic. The oldest cases extend back beyond 200,000 years ago in both early H. sapiens and the Neandertals, and usewear studies point to far more ancient origins. This chapter reviews the metamorphosis in theoretical expectations around these technologies, and the cognitive models that have evolved in response to accumulating archaeological data. It also examines the increasing sophistication in the study of Palaeolithic adhesives and hafting, in particular in terms of material constituents and properties, and how that relates to choices made by their producers. Of course, adhesives and composite artifacts are closely bounded in practical and cognitive terms, and moreover are entangled with other aspects such as materiality, creativity, forethought, and memory. The wider implications for the minds of Neandertals and early H. sapiens are here examined within a landscape context of embodied engagement.
Datura, the Mimbres Flower World, and Ideational Cognition
Authors: VanPool Christine S. , Berlant Tony , Maurer Evan , VanPool Todd L. , Wynn Thomas 
Published: May 2023

Abstract
Prehistoric and historic Native Americans had a physical, practical, and spiritual engagement with the environment. These relationships caused their perception to become intertwined with specific creatures and plants, which became part of the basis of their ideational worldviews. In the case of the Mimbres people who lived between AD 1000–1140, their engagement with datura, a plant with powerful hallucinogenic properties, integrated into a cosmological framework called the Flower World. The visions provided by datura allowed people to travel into the otherwise hidden Flower World realm. To understand their ideational world, we employ an ethnosemantic approached based on ecological and neuropsychological models to analyze Classic Mimbres images depicted on Black-on-white pottery bowls. These images reflect ecological relationships (e.g., the association of the hawkmoth and datura, the opening of datura blossoms) and also the altered states of consciousness created by ingesting datura. These include depictions of geometric designs characteristic of datura intoxication, spinning (which coincides with the opening datura blossom) and the transformation of a person into a spirit being like a mothman. Applying cognitive models to Mimbres imagery consequently provides an understanding of Mimbres cosmology and the cultural importance of ecological relationships that structured the Mimbres ideational worldview.
Symbolism in the Middle Palaeolithic
Authors: van Mazijk Corijn 
Published: May 2023

Abstract
The existence and extent of symbolism among Middle Palaeolithic pre-modern humans present a significant point of controversy. As with any scientific dispute, there is a substantial conceptual component to these discussions, here in particular concerning the concept of symbolism, which is often poorly defined. The present chapter approaches the problem from a different, philosophical, angle. It opens with a brief reflection on the phenomenological method in philosophy and its largely unexplored potential for paleoanthropology and evolutionary psychology. The midpart develops a phenomenological framework involving separate levels of expressive and symbolic behavior. It is argued that Middle Palaeolithic pre-modern humans, given the current evidence, are best understood as capable of symbolic behavior, but that symbol use is still tied to expressive behavior and shared practices in the so-called living present. It is further argued that such “practice-embedded symbolism” represents a necessary stage in the evolution of symbolism in the hominin lineage, as its use and interpretation are significantly less cognitively demanding than the free symbolic activity of behaviorally modern humans. The final section reviews evidence for the decorative use of pigment and beadwork in Middle Palaeolithic communities. It is argued that while their production plausibly relied on practice-embedded symbols, free symbolism in the modern sense need not be presupposed, and it is unlikely that either pigment or beadwork had itself a symbolic function.
Deep Listening with Pauline Oliveros
Authors: Halstead Jill , Hilder Thomas R. 
Published: May 2023

Abstract
This chapter considers the work of Pauline Oliveros (1932–2016), in particular her philosophy and practice of ‘Deep Listening’. Oliveros’ life and work provide radical inspiration for those engaged in the field of music therapy, and anyone concerned with sound’s deep capacity to connect us to the present moment, each other, and the world. This chapter is based around our own responses to a selection of questions posed by Oliveros in her Listening Questions. Through writing, we attend to our own listening memories, habits, and disciplining; reflect on the socially power inflected nature of listening; and share our transformations and ethics in the sound-worlds of academia, musical culture, and everyday life. Drawing on our experiences as musicians, pedagogues, researchers, and activists, we propose a form of ‘queer listening’ nurtured through the ‘queer ear’, an artful disruption of the traditional hierarchies and power relations which continue to define western practices of listening. This queer ear invites us to attend to our broader collectives through the labour of radical care, and proposes an anti-oppressive philosophy and practice in different spheres of music making, research and education, thus providing fertile ground from which queer and trans music therapy can grow.
Defining Parasocial Relationship Experiences
Authors: Giles David 
Published: May 2023

Abstract
The chapter offers a conceptual definition of parasocial relationships as a distinct construct, and it explores its theoretical relationship to other related phenomena. It defines various types of parasocial relationships, and it outlines the scope of these experiences, including their prevalence across different media formats, channels, and platforms and different types of media content. The chapter explicates how parasocial relationships are different from, yet related to, other media experiences, such as parasocial interactions, parasocial attachment, fandom, celebrity worship, and character identification and to what extent they can be applied to describe other forms of engagement (e.g., with brands).
Experimental Studies of Cultural Evolution
Authors: Mesoudi Alex 
Published: May 2023

Abstract
This chapter reviews how experiments have played a growing role in the study of cultural evolution recently. Experiments occupy a middle ground between formal models and real-world observational and historical studies. Like models, they offer the advantages of control and manipulation in order to determine causal relations between variables. Like real-world studies, they involve actual human behaviour, albeit constrained within artificial boundaries. When interpreted within the context of this trade-off between external and internal validity, experiments can provide valuable insights into the processes and dynamics of cultural evolution. Given the centrality of social learning in theories of cultural evolution, experiments typically involve participants learning from at least one other participant. Various experimental designs have been employed including dyadic interactions, linear transmission chains, closed groups, replacement or migration methods, and economic games. Key findings relate to content and inductive biases that describe how the content of cultural traits affects their transmission and evolution; context biases concerning from whom traits are copied; studies probing the socio-cognitive and demographic factors that underpin cumulative cultural evolution; the burgeoning experimental study of non-human culture; and variation in learning strategies over the lifetime and across cultures. The chapter ends with some recommendations for future experimental research, including an awareness of the proper function and limitations of experimental methods; the need for closer links between experiments, theory, and real-world data; and the necessity for experiments to be both replicable and reproducible via open science practices, to ensure that new generations of scientists can build on reliable knowledge.
Impact of age and tumor size on the development of the Kasabach–Merritt phenomenon in patients with kaposiform hemangioendothelioma: a retrospective cohort study
Authors: Zhou Jiangyuan , Lan Yuru , Qiu Tong , Gong Xue , Zhang Zixin , He Chunshui , Peng Qiang , Hu Fan , Zhang Xuepeng , Lu Guoyan , Qiu Liqing , Kong Feiteng , Zhang Yongbo , Chen Siyuan , Ji Yi 
Published: May 2023

Abstract

Introduction
The Kasabach–Merritt phenomenon (KMP) is a severe complication of kaposiform hemangioendothelioma (KHE). The risk factors for KMP need further investigation.

Methods
The medical records of patients with KHE were reviewed. Univariate and multivariate logistic regression models were used for the risk factors for KMP, and the area under the receiver operator characteristic (ROC) curve was used to assess the predictive power of risk factors.

Results
A total of 338 patients with KHE were enrolled. The incidence of KMP was 45.9%. Age of onset (P &lt; 0.001, odds ratio [OR] 0.939; 95% confidence interval [CI] 0.914–0.966), lesion size (P &lt; 0.001, OR 1.944; 95% CI 1.646–2.296), mixed type (P = 0.030, OR 2.428; 95% CI 1.092–5.397), deep type (P = 0.010, OR 4.006; 95% CI 1.389–11.556), and mediastinal or retroperitoneal lesion location (P = 0.019, OR 11.864; 95% CI 1.497–94.003) were correlated with KMP occurrence through multivariate logistic regression. ROC curve analysis revealed that the optimal cutoffs were 4.75 months for the age of onset (P &lt; 0.001, OR 7.206, 95% CI 4.073–12.749) and a lesion diameter of 5.35 cm (P &lt; 0.001, OR 11.817, 95% CI 7.084–19.714). Bounded by a lesion size of 5.35 cm, we found significant differences in tumor morphology, age of onset, treatments, and hematological parameters. Using an onset age of 4.75 months as a cutoff, we found significant differences in tumor morphology, lesion size, hematological parameters, and prognosis.

Conclusion
For KHE patients with an onset age &lt;4.75 months and/or lesion diameter &gt;5.35 cm, clinicians should be wary of the occurrence of KMP. Active management is recommended to improve the prognosis.
Metformin Improves Functional Outcomes, Activates Neural Precursor Cells, and Modulates Microglia in a Sex-Dependent Manner After Spinal Cord Injury
Authors: Gilbert Emily A B , Livingston Jessica , Garcia-Flores Emilio , Kehtari Tarlan , Morshead Cindi M 
Published: May 2023

AbstractSpinal cord injury (SCI) results in devastating patient outcomes with few treatment options. A promising approach to improve outcomes following SCI involves the activation of endogenous precursor populations including neural stem and progenitor cells (NSPCs) which are located in the periventricular zone (PVZ), and oligodendrocyte precursor cells (OPCs) found throughout the parenchyma. In the adult spinal cord, resident NSPCs are primarily mitotically quiescent and aneurogenic, while OPCs contribute to ongoing oligodendrogenesis into adulthood. Each of these populations is responsive to SCI, increasing their proliferation and migration to the site of injury; however, their activation is not sufficient to support functional recovery. Previous work has shown that administration of the FDA-approved drug metformin is effective at promoting endogenous brain repair following injury, and this is correlated with enhanced NSPC activation. Here, we ask whether metformin can promote functional recovery and neural repair following SCI in both males and females. Our results reveal that acute, but not delayed metformin administration improves functional outcomes following SCI in both sexes. The functional improvement is concomitant with OPC activation and oligodendrogenesis. Our data also reveal sex-dependent effects of metformin following SCI with increased activation of NSPCs in females and reduced microglia activation in males. Taken together, these findings support metformin as a viable therapeutic strategy following SCI and highlight its pleiotropic effects in the spinal cord.