bluuebunny/crossref_metadata_2025_split huggingface dataset:
A diet rich in omega-3 fatty acid improves periodontitis and tissue destruction by MMP2- and MMP9-linked inflammation in a murine model
Authors: González-Alva Patricia , Solís-Suárez Diana Laura , Cifuentes-Mendiola Saúl Ernesto , García-Hernández Ana Lilia 
Published: June 2023

AbstractPeriodontitis is an oral-cavity inflammatory disease and is the principal cause associated with tooth loss. Matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) are important proteases involved in periodontal tissue destruction. The omega-3 polyunsaturated fatty acids (ω-3 PUFA) have been demonstrated to possess immunoregulatory properties in periodontitis. The aim of the study was to investigate the effects of ω-3 PUFA on inflammation and on the expression of MMP-2 and -9 in a murine periodontitis model. Twenty-four male C57BL/6 mice were divided into control mice (Control), control mice treated with ω-3 PUFA (O3), mice with periodontitis (P), and mice with periodontitis treated with ω-3 PUFA (P + O3). ω-3 PUFA were administered orally once a day for 70 days. Periodontitis in mice was induced by Porphyromonas gingivalis-infected ligature placement around the second maxillary molar. The mice were sacrificed, and blood and maxillary samples were collected. Flow cytometry was used to quantify tumor necrosis factor-alpha (TNFα), interleukin (IL)-2, IL-4, IL-5, and interferon-gamma. Histologic analysis and immunohistochemistry for MMP-2 and -9 were performed. The data were statistically evaluated using analysis of variance (ANOVA) and the Tukey post hoc test. Histological analysis showed that ω-3 PUFA supplementation prevented inflammation and tissue destruction and revealed that bone destruction was more extensive in the P group than in the P + O3 group (p < 0.05). Also, it decreased the serum expressions of TNFα and IL-2 and the tissue expression of MMP-2 and -9 in the periodontitis-induced model (p < 0.05). ω-3 PUFA supplementation prevented alveolar bone loss and periodontal destruction, probably by decreasing the expression of MMP-2 and MMP-9 and its immunoregulatory properties.
Health literacy across personality traits among older adults: cross-sectional evidence from Switzerland
Authors: Ryser Valérie-Anne , Meier Clément , Vilpert Sarah , Maurer Jürgen 
Published: June 2023

AbstractThis research aims to better understand the association of personality traits (PT)—Openness to Experience, Conscientiousness, Extraversion, Agreeableness, and Neuroticism—with health literacy (HL) skills of adults aged 58 years and older in a nationally representative sample from Switzerland. Analyses were conducted on a subsample (n = 1546) of respondents living in Switzerland from wave 8 (2019/2020) of the Survey of Health, Ageing, and Retirement in Europe (SHARE). PT were assessed with the Big-Five inventory ten (BFI-10). HL was measured using the short version of the European Health Literacy Survey questionnaire (HLS-EU-Q16). We used multivariable regressions to explore how respondents' PT are independently associated with (1) the HLS-EU-Q16 and (2) seven sub-indices derived from this HL scale. Results demonstrated that even when controlling for social, regional, and health characteristics, PT were significantly associated with HL among older adults in Switzerland. More open individuals showed better HL competencies. By contrast, individuals who scored higher on neuroticism expressed more difficulties regarding concrete health-relevant tasks or situations. These findings call for public health policies targeting older adults with lower levels of openness who are less likely to engage in self-examination, and individuals with higher levels of neuroticism who tend to experience more negative emotions. Moreover, health information and communication strategies content development that accounts for different personality types and addresses the needs of individuals with low levels of openness and high neuroticism may help improve HL among older adults whose personalities may otherwise put them at a disadvantage in handling health information.
Sustainability and intermodality in humanitarian logistics: a two-stage multi-objective programming formulation
Authors: Rodríguez-Espíndola Oscar , Dey Prasanta , Albores Pavel , Chowdhury Soumyadeb 
Published: June 2023

AbstractWhen managing crises and disasters, decision-makers face high uncertainty levels, disrupted supply chains, and damaged infrastructure. This complicates delivering resources that are essential for the survival of the victims. Flexible and adaptable supply networks are needed to ensure a consistent flow of relief to the areas affected by disasters. Intermodality is a valuable approach when infrastructure is damaged, as it allows the use of different delivery modes to reach demand areas. Nevertheless, involving different transportation modes has an impact on the environment. Looking at the importance of helping victims and considering the environmental impact of humanitarian operations for long-term sustainability, intermodality and carbon emission reduction measures can be an interesting combination. This area, however, is currently understudied. This article introduces a two-stage stochastic formulation to fill that gap. The model addresses facility location, resource allocation, and intermodal relief distribution considering carbon emission reduction in facilities, intermodal activities, and distribution. The formulation minimises costs and the level of shortage of relief. The model is tested using a case study in Sinaloa, Mexico, to investigate the impact of intermodality and carbon emission reduction measures on costs and shortage of relief for disaster victims. The findings confirm that the model proposed allows for the diversification of transportation modes and reduces carbon emissions whilst achieving a good level of performance in both metrics. The comparison with a benchmark model without intermodality and carbon reduction measures suggests that the formulation can increase flexibility and reduce the level of CO2 emissions whilst maintaining high satisfaction rates.
An empirical study of automated privacy requirements classification in issue reports
Authors: Sangaroonsilp Pattaraporn , Choetkiertikul Morakot , Dam Hoa Khanh , Ghose Aditya 
Published: June 2023

AbstractThe recent advent of data protection laws and regulations has emerged to protect privacy and personal information of individuals. As the cases of privacy breaches and vulnerabilities are rapidly increasing, people are aware and more concerned about their privacy. These bring a significant attention to software development teams to address privacy concerns in developing software applications. As today’s software development adopts an agile, issue-driven approach, issues in an issue tracking system become a centralised pool that gathers new requirements, requests for modification and all the tasks of the software project. Hence, establishing an alignment between those issues and privacy requirements is an important step in developing privacy-aware software systems. This alignment also facilitates privacy compliance checking which may be required as an underlying part of regulations for organisations. However, manually establishing those alignments is labour intensive and time consuming. In this paper, we explore a wide range of machine learning and natural language processing techniques which can automatically classify privacy requirements in issue reports. We employ six popular techniques namely Bag-of-Words (BoW), N-gram Inverse Document Frequency (N-gram IDF), Term Frequency-Inverse Document Frequency (TF-IDF), Word2Vec, Convolutional Neural Network (CNN) and Bidirectional Encoder Representations from Transformers (BERT) to perform the classification on privacy-related issue reports in Google Chrome and Moodle projects. The evaluation showed that BoW, N-gram IDF, TF-IDF and Word2Vec techniques are suitable for classifying privacy requirements in those issue reports. In addition, N-gram IDF is the best performer in both projects.
The Association Between Thymidylate Synthase Gene Polymorphisms and the Risk of Ischemic Stroke in Chinese Han Population
Authors: Yu Fuhua , Shi Lei , Wang Qianru , Xing Xiaohui , Li Zhongchen , Hou Lei , Zhou Zhengshan , Wang Zengguang , Xiao Yilei 
Published: June 2023

AbstractFamily history of hypertension, smoking, diabetes and alcohol consumption and atherosclerotic plaque were identified as common risk factors in IS. We aimed at investigating the relationship between Thymidylate Synthase (TS) gene polymorphisms and ischemic stroke (IS).This case–control research selected and genotyped three single nucleotide polymorphisms (SNPs)of TS( rs699517, rs2790, and rs151264360) with Sanger sequencing in Chinese Han population. We also adopted logistic regression analysis in genetic models for calculating odds ratios and 95% confidence intervals. Genotype-Tissue Expression(GTEx) database analyzed the tissue-specific expression and TS polymorphisms. The ischemic stroke patients showed higher low-density lipoprotein cholesterol and total homocysteine (tHcy). It was found that patients with the TT genotype of rs699517 and GG genotype of rs2790 had larger degrees of tHcy than those with CC + CT genotypes and AA + AG genotypes, respectively. The genotype distribution of the three SNPs did not deviate from Hardy–Weinberg equilibrium (HWE). Haplotype analysis showed that T-G-del was the major haplotype in IS, and C-A-ins was the major haplotype in controls. GTEx database indicated that the rs699517 and rs2790 increased the expression of TS in healthy human and associated with TS expression level in a single tissue. In conclusion: This study has shown that TS rs699517 and rs2790 were significantly related to ischemic stroke patients.
Expressing Dual Concern in Criticism for Wrongdoing: The Persuasive Power of Criticizing with Care
Authors: Howe Lauren C. , Shepherd Steven , Warren Nathan B. , Mercurio Kathryn R. , Campbell Troy H. 
Published: June 2023

AbstractTo call attention to and motivate action on ethical issues in business or society, messengers often criticize groups for wrongdoing and ask these groups to change their behavior. When criticizing target groups, messengers frequently identify and express concern about harm caused to a victim group, and in the process address a target group by criticizing them for causing this harm and imploring them to change. However, we find that when messengers criticize a target group for causing harm to a victim group in this way—expressing singular concern for the victim group—members of the target group infer, often incorrectly, that the messenger views the target group as less moral and unworthy of concern. This inferred lack of moral concern reduces criticism acceptance and prompts backlash from the target group. To address this problem, we introduce dual concern messaging—messages that simultaneously communicate that a target group causes harm to a victim group and express concern for the target group. A series of several experiments demonstrate that dual concern messages reduce inferences that a critical messenger lacks moral concern for the criticized target group, increase the persuasiveness of the criticism among members of the target group, and reduce backlash from consumers against a corporate messenger. When pursuing justice for victims of a target group, dual concern messages that communicate concern for the victim group as well as the target group are more effective in fostering openness toward criticism, rather than defensiveness, in a target group, thus setting the stage for change.
Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
Authors: Janin Maxime , Davalos Veronica , Esteller Manel 
Published: June 2023

AbstractMost of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in cancer origin and progression has been extensively demonstrated during the last years. Both regulations share similar mechanisms driven by DNA or RNA modifiers, namely writers, readers, and erasers; enzymes responsible of respectively introducing, recognizing, or removing the epigenetic or epitranscriptomic modifications. Epigenetic regulation is achieved by DNA methylation, histone modifications, non-coding RNAs, chromatin accessibility, and enhancer reprogramming. In parallel, regulation at RNA level, named epitranscriptomic, is driven by a wide diversity of chemical modifications in mostly all RNA molecules. These two-layer regulatory mechanisms are finely controlled in normal tissue, and dysregulations are associated with every hallmark of human cancer. In this review, we provide an overview of the current state of knowledge regarding epigenetic and epitranscriptomic alterations governing tumor metastasis, and compare pathways regulated at DNA or RNA levels to shed light on a possible epi-crosstalk in cancer metastasis. A deeper understanding on these mechanisms could have important clinical implications for the prevention of advanced malignancies and the management of the disseminated diseases. Additionally, as these epi-alterations can potentially be reversed by small molecules or inhibitors against epi-modifiers, novel therapeutic alternatives could be envisioned.
Neuronal Responses to Ischemia: Scoping Review of Insights from Human-Derived In Vitro Models
Authors: Voogd Eva J. H. F. , Frega Monica , Hofmeijer Jeannette 
Published: June 2023

AbstractTranslation of neuroprotective treatment effects from experimental animal models to patients with cerebral ischemia has been challenging. Since pathophysiological processes may vary across species, an experimental model to clarify human-specific neuronal pathomechanisms may help. We conducted a scoping review of the literature on human neuronal in vitro models that have been used to study neuronal responses to ischemia or hypoxia, the parts of the pathophysiological cascade that have been investigated in those models, and evidence on effects of interventions. We included 147 studies on four different human neuronal models. The majority of the studies (132/147) was conducted in SH-SY5Y cells, which is a cancerous cell line derived from a single neuroblastoma patient. Of these, 119/132 used undifferentiated SH-SY5Y cells, that lack many neuronal characteristics. Two studies used healthy human induced pluripotent stem cell derived neuronal networks. Most studies used microscopic measures and established hypoxia induced cell death, oxidative stress, or inflammation. Only one study investigated the effect of hypoxia on neuronal network functionality using micro-electrode arrays. Treatment targets included oxidative stress, inflammation, cell death, and neuronal network stimulation. We discuss (dis)advantages of the various model systems and propose future perspectives for research into human neuronal responses to ischemia or hypoxia.
Graphical Abstract
Cloud benchmarking and performance analysis of an HPC application in Amazon EC2
Authors: Dancheva Tamara , Alonso Unai , Barton Michael 
Published: June 2023

AbstractCloud computing platforms have been continuously evolving. Features such as the Elastic Fabric Adapter (EFA) in the Amazon Web Services (AWS) platform have brought yet another revolution in the High Performance Computing (HPC) world, further accelerating the convergence of HPC and cloud computing. Other public clouds also support similar features further fueling this change. In this paper, we show how and why the performance of a large-scale computational fluid dynamics (CFD) HPC application on AWS competes very closely with the one on Beskow—a Cray XC40 supercomputer at the PDC Center for High-Performance Computing - in terms of cost-efficiency with strong scaling up to 2304 processes. We perform an extensive set of micro and macro benchmarks in both environments and conduct a comparative analysis. Until as recently as 2020 these benchmarks have notoriously yielded unsatisfactory results for the cloud platforms compared with on-premise infrastructures. Our aim is to access the HPC capabilities of the cloud, and in general to demonstrate how researchers can scale and evaluate the performance of their application in the cloud.
Mapping Children’s Actions in the Scaffolding Process Using Interactive Whiteboard
Authors: Masoumi Davoud , Bourbour Maryam , Lindqvist Gunilla 
Published: June 2023

AbstractThis study aims to examine children’s actions in relation to the preschool teacher’s scaffolding action in a context where an interactive whiteboard (IWB) is used. Over five months, 22 children aged between 4 and 6 years old, along with their five preschool teachers, were video observed. The study of these teaching moments has provided a rich seam of evidence that details the ways children act in relation to their teacher’s scaffolding. The results show that children manifest 12 distinct actions including: Giving short responses, Approaching the IWB to engage in the teaching activities; Explaining, Experimenting; Smiling and laughing; Pointing and showing; Working together; Challenging each other; Solving a problem; Using language in meaningful contexts; Expressing emotions; and Comparing the similarities and differences. By mapping children’s actions in the scaffolding process, which are often undermined or ignored in the existing research, the findings of this study have expanded and deepened our understanding of the scaffolding process and the notion of scaffolding itself. The findings, further, exemplify how just providing support can contribute to early childhood education, since early interventions, such as the ways preschool teachers scaffold children’s actions, are particularly crucial for children’s learning and development.
Potential use of nanoparticles produced from byproducts of drinking water industry in stabilizing arsenic in alkaline-contaminated soils
Authors: Moharem Mohamed L. , Hamadeen Hala M. , Mesalem Mohamed O. , Elkhatib Elsayed A. 
Published: June 2023

AbstractThe stabilization of heavy metals in soils is considered a cost-effective and environmentally sustainable remediation approach. In the current study, the applicability of water treatment residual nanoparticles (nWTRs) with the particle size ranged from 45 to 96 nm was evaluated for its efficacy in reducing arsenic mobility in clayey and sandy contaminated alkaline soils. Sorption isotherms, kinetics, speciation and fractionation studies were performed. Sorption equilibrium and kinetics studies revealed that As sorption by nWTRs-amended soils followed Langmuir and second-order/power function models. The maximum As sorption capacity (qmax) of Langmuir increased up to 21- and 15-folds in clayey and sandy soils, respectively, as a result of nWTRs application at 0.3% rate. A drastic reduction in non-residual (NORS) As fraction from 80.2 and 51.49% to 11.25 and 14.42% for clayey and sandy soils, respectively, at 0.3% nWTRs application rate was observed, whereas residual (RS) As fraction in both studied soils strongly increased following nWTRs application. The decline in percentage of As mobile form (arsenious acid) in both soils after nWTRs application indicated the strong effect of nWTRs on As immobilization in contaminated soils. Furthermore, Fourier transmission infrared spectroscopy analysis suggested reaction mechanisms between As and the surfaces of amorphous Fe and Al oxides of nWTRs through OH groups. This study highlights the effective management approach of using nWTRs as soil amendment to stabilize As in contaminated alkaline soils.
An Analysis of Domestic Fire Smoke/Toxic Fumes Inhalation Injuries
Authors: Taylor Mark , Francis Hulya , Fielding John 
Published: June 2023

AbstractPrevious studies indicated that inhalation of smoke and toxic fumes is the most common form of domestic fire injury. In this article we examine the socio-demographic, contributory, and firefighting behaviour factors associated with accidental dwelling fire smoke / toxic fumes inhalation injuries. In particular, we examine age band, gender, occupancy level, deprivation, alcohol / drug consumption, and attempting to fight a domestic fire in the Merseyside area of North-West England covered by Merseyside Fire and Rescue Service over the period 2011 to 2022. Smoke / toxic fumes inhalation injuries occurred more in single occupancy as opposed to multiple occupancy dwellings by a ratio of 2 to 1 over the period studied. The majority of the accidental dwelling fire smoke / toxic fumes inhalation injuries occurred in areas with the highest level of deprivation within the area studied. Alcohol / drug consumption was a contributory factor in roughly 14% of the smoke / toxic fumes inhalation injuries. Smoke / toxic fumes inhalation injuries sustained attempting to fight the fire constituted roughly 12% of the total number of smoke / toxic fumes inhalation injuries over the period studied.
Canola productivity and carbon footprint under different cropping systems in eastern Canada
Authors: Ma Bao-Luo , Liang Chang , Herath Aruna , Caldwell C. D. , Smith Donald L. 
Published: June 2023

AbstractDiversified crop rotation with an appropriate sequence may be a promising strategy for increasing crop productivity while reducing greenhouse gas emissions (GHGs) and lowering carbon (C) footprint for more sustainable agricultural systems. The objectives of this study were to (i) assess the agronomic performance and C footprint of canola (Brassica napus L.) production in different cropping systems, and (ii) better understand how canola could be adapted to existing cropping systems in eastern Canada. A four-year canola-based phase rotation study, including maize (Zea mays L.), wheat (Triticum aestivum L.), and soybean (Glycine max L.), started in 2011 and continued for two cycles in Ottawa, ON; Montreal, QC; and Canning, NS. It was found that, compared to continuous monoculture (canola, maize or wheat), diversified cropping systems increased crop yields by an average of 32% and reduced the C footprint of all rotations by 33%, except under severe heat and drought conditions. The effect of rotation on yield and C footprint of canola production varied significantly among site-years. At Ottawa, the canola following soybean (SC) had 12% higher canola yield than monoculture canola (CC), 5 and 8% higher canola yield than canola following wheat (WC) or maize (MC). At Montreal, canola yield ranked as MC > SC > WC > CC. At Canning, the highest canola yield was in WC (21%) and SC (13%). Overall, most SC rotations had the lowest C footprint, and CC cropping had the highest C footprint, with only a few exceptions. Regardless of the cropping system, canola required more N input and was high in oil and protein in the harvested product, and produced the highest C footprint, while soybean had the lowest C footprint at all three sites. Our findings indicate that a diversified cropping system with canola production following soybean significantly improved canola yield while lowering the C footprint. However, profitable and sustainable canola production in eastern Canada is threatened by climate change-induced drought and heat stress.