bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opportunities and barriers for reimbursement of digital therapeutics in Austria: Findings From expert interviews
Authors: Sareban Mahdi , Treff Gunnar , Smeddinck Jan David , Hussein Rada , Niebauer Josef 
Published: January 2025

Background Digital therapeutics (DTx) are software-based interventions that aim to prevent or treat especially non-communicable diseases. Currently, no framework for reimbursement of DTx exists in Austria. The aim of this study was to gather a comprehensive perspective on regulatory considerations of Austrian stakeholders with regard to reimbursement of DTx and to outline strategies for establishing a national reimbursement framework. Methods Based on a stakeholder analysis, seven semi-structured interviews with Austrian experts from the digital health-related fields medicine, public health, health technology assessment, health industry and social security providers were conducted. Interviews were analyzed according to seven predefined themes. Results Overall, participants agreed that reimbursement of DTx by the public insurance in Austria is desirable. Prerequisites are (i) a high user and prescriber acceptance of DTx, which must be integrated into a transparent and interoperable Austrian e-Health infrastructure, (ii) a sufficient, risk-based level of evidence for clinical effectiveness, (iii) national authorities that transparently provide evidence-base, indications, contra-indications and potential risks, (iv) adopting European regulations about data security, secondary use of data and use of artificial intelligence and (v) a health-economical evaluation of DTx. Conclusion A comprehensive national strategy for reimbursing DTx will need to consider technical, scientific and socio-economical requirements, patient safety and liability, secure health data handling and use of artificial intelligence in order to establish a sound framework with equitable access also for socioeconomically disadvantaged persons in order to address the growing burden of non-communicable diseases.
Applicability of the decomposed theory of planned behavior for the evaluation of community-dwelling older adults’ acceptance in continuous usage of robot-assisted board games for cognitive training
Authors: Huang Chiu-Mieh , Huang Su-Fei , Chen Yu-Ting , Chang Ching-Hao , Chien Hsiu-Chun , Chang Ying-Jie , Huang Kuei-Yu , Guo Jong-Long 
Published: January 2025

Background Improving cognitive function in healthy older adults is a global concern. Cognitive training delays mental deterioration. The utilization of robots and board games for aiding older adults in cognitive training represents a prominent technological trend and is a subject of meriting investigation. Objective This study evaluates the acceptability and factors influencing the continuous usage intention of a robot-assisted board game (RABG) for cognitive training in community-dwelling older adults based on the decomposed theory of planned behavior (DTPB). Methods In this explanatory study, we developed an RABG with six educational modules. The experiences of 126 older adults recruited from northern Taiwan who completed the program were assessed using a DTPB-based questionnaire. Partial least-squares structural equation modeling was used to examine the correlations. Results The results demonstrate the DTPB's sufficient fitness and 79.9% explanatory power for the continuous usage intention of the RABG, confirming the effectiveness of the proposed structural model. Perceived usefulness positively affected attitude and continuous usage intention, indicating that perceived usefulness is critical in promoting older adults’ continuous usage intention. The interpersonal influence was a major antecedent of subjective norms. Self-efficacy affects perceived behavioral control. Attitudes and perceived behavioral control affected users’ intentions to use the RABG. Conclusions Our findings support the applicability of the DTPB in evaluating RABGs for cognitive training in older adults, suggesting its potential integration in future interventions.
Factors associated with self-reported work ability among people with multiple sclerosis in Sweden
Authors: Teni Fitsum Sebsibe , Machado Alejandra , Dervish Jessica , Fink Katharina , Gyllensten Hanna , Friberg Emilie 
Published: January 2025

Background Work ability index (WAI) is an instrument that measures work ability in workplace surveys and health examinations in occupational health and research. It has been used in different population groups. But research is limited among people with multiple sclerosis (PwMS). Objective To determine the factors associated with work ability among PwMS in Sweden. Methods A total of 4103 PwMS who answered a web-based survey were included in the analysis. Work ability was assessed using the work ability score (WAS) component of WAI. Univariable and multivariable linear regression analyses were performed to assess the association of sociodemographic, clinical, and self-reported health variables with WAS. Results Just over half of the PwMS reported good (37.0%) or excellent (16.3%) WAS. The overall mean WAS was 6.9 (standard deviation = 2.8). Health-related quality of life (R-squared = 31.6%), fatigue (28.3%), occupation (22.6%), and expanded disability status scale (EDSS) score (18.1%), explained the highest proportions of variation in WAS, individually. In the adjusted model, occupation, EDSS score, and fatigue had the strongest associations with WAS with significantly lower scores in those with no occupation, higher EDSS score, and severe fatigue levels. Conclusion Work ability among PwMS was lower than in the general population in Sweden. Occupation, EDSS score and fatigue were among the most important factors associated with work ability.
Examining the Prevalence of Sports-Related Injuries in Collegiate Baseball Players
Authors: Ishikawa Hiroaki , Cushman Daniel M. , Tashjian Robert Z. , Chalmers Peter N. 
Published: January 2025

Background: Sports-related injuries remain a significant problem for collegiate baseball players. Although some studies reported the epidemiology of sports-related injuries among collegiate baseball players, the latest information on sport-related injuries should be provided. Purpose: To examine the current trends of sports-related injuries among collegiate baseball players in the Pacific 12 (PAC-12) Conference. Study Design: Descriptive epidemiology study. Methods: Demographic and injury data were obtained from a database of the PAC-12 Health Analytics Program between 2016 and 2021. Injury incidence, type, mechanism, and outcome were analyzed. The annual incidence of injuries was defined as the number of injuries per total players for 1 year. Detailed reports of the 20 most common specific diagnoses were generated. Results: A total of 1434 sports-related injuries occurred in 6 years, with the number increasing from 2016 (n = 75; incidence, 8.5 per 100 player-years) to 2021 (n = 378; incidence, 43 per 100 player-years). Most of the injuries occurred in pitchers (33.6%), were acute (76.6%), resulted in missed time (68.8%), and were new injuries (86.9%). In addition, most injuries were caused by noncontact events (53.2%) and occurred during in-season games (39.9%) and practice (47.4%). Only 1.3% of sports-related injuries did not result in a return to the previous activity level. Rotator cuff tendon injuries were the most common specific diagnoses (n = 98), followed by ulnar collateral ligament (UCL) injuries (n = 63), hamstring muscle strains (n = 60), ankle ligament sprains (n = 46), and hand/wrist fractures (n = 40). UCL injuries had the highest proportion of surgical interventions (41.3% of all UCL injuries) and the longest days to clearance (167 ± 197 days) among the 20 most common diagnoses. Conclusion: The number of sports-related injuries among PAC-12 collegiate baseball players has increased by approximately 5 times over the past 6 years. Rotator cuff tendon injuries followed by UCL injuries, hamstring muscle strains, ankle ligament sprains, and hand/wrist fractures are the most common specific diagnoses among this cohort of collegiate baseball players. Of the 20 most common specific diagnoses, UCL injuries most often require surgical interventions and had the longest return to playtime.
Changing or validating physician opioid prescribing behaviors through audit and feedback and academic detailing interventions in primary care
Authors: Laur Celia , Kithulegoda Natasha , McCleary Nicola , Nicholas Angl Emily , Strange Michael , Sklar Barbara , Sribaskaran Thivja , Dobell Gail , Gushue Sharon , Lam Jonathan M. C. , Bevan Lindsay , Burton Victoria , Salach Lena , Presseau Justin , Desveaux Laura , Ivers Noah 
Published: January 2025

Background In Ontario, Canada, province-wide initiatives supporting safer opioid prescribing in primary care include voluntary audit and feedback reports and academic detailing. In this process evaluation, we aimed to determine the fidelity of delivery and receipt of the interventions, the observed change strategies used by physicians, potential mechanisms of action, and how complementary the initiatives can be to each other. Method Semi-structured interviews were conducted with academic detailers and with physicians who received both interventions. Academic detailer interviews were coded using the Behavior Change Technique Taxonomy; physician interviews were coded to the Theoretical Domain Framework. Change strategies were summarized based on academic detailer intentions and physician-reported practice changes. Potential mechanisms of action were identified using the Theories and Techniques Tool and the literature. Patient partners informed the interpretation of results through ongoing group discussions of preliminary findings. Results Interviews were conducted with eight academic detailers and 12 physicians. Change strategies described by academic detailers to support physicians’ opioid prescribing included problem solving, instructions on how to perform the behavior, adding objects to the environment, credible source, shaping knowledge, and social support. Physicians mentioned that academic detailing validated current opioid practices or increased their belief about capabilities and their intentions, mediated by increased skills and the impact of environmental context and resources. Potential mechanisms of action included behavioral regulation, behavioral cueing, and general attitudes/beliefs. On its own, receiving the audit and feedback report did not lead to changes in beliefs about prescribing practices; however, for some physicians, it provided validation and reassurance. Physicians saw unrealized potential for complementarity. Conclusions New interventions are often implemented in a complex ecosystem with other competing interventions. In this study, we show how examining the fidelity of the intervention from initial design through to delivery can identify opportunities for potential optimization.
Development and Outcomes of a Provider-Driven, Online Continuing Education Program on Integrative Palliative Care: Randomized Controlled Trial
Authors: Collinge William , Kozak Leila , Mist Scott , Soltysik Robert 
Published: January 2025

Background Integrative therapies are increasingly in demand for both symptom management and quality of life in palliative care (PC) populations. Multidisciplinary PC professionals need continuing education/continuing medical education (CE/CME) to keep current on the evidence-informed use of integrative therapies in PC planning. Objectives (1) Elicit input from multidisciplinary PC providers on needs for CE/CME content on integrative care, and indicators of implementation for use in impact assessment. (2) Produce an online CE/CME program responsive to provider input. (3) Assess program impact on PC providers in a randomized controlled trial. Methods Focus groups with 47 multidisciplinary PC personnel assessed needs for CE/CME content and identified practice-related behaviors indicating implementation of integrative care. Qualitative analysis then informed development a 9-hour CE/CME program, and identified candidate items for an outcome measure (Integrative Practice Assessment) to assess impact. Validation testing followed with 63 new subjects. A randomized, waitlist-controlled trial then assessed program impact on (1) confidence understanding evidence-informed use of integrative therapies in PC, and (2) implementation of practice behaviors that promote integrative care. Results 213 subjects were randomized and 170 provided follow-up data on program impact. Subjects’ confidence (10-point scale) understanding safety considerations increased from 5.4 to 8.7; recommending modalities, from 4.2 to 8.3; and explaining modalities, from 4.8 to 8.5. Direct actions promoting integrative care in the last 10 patient encounters increased (12.2 to 17.9). Indirect actions taken in the work setting increased in the past month to advocate integrative therapies (from 5.7 to 9.1), and to promote organizational change (from 10.9 to 18.2). (All outcomes P < .001). Conclusion This provider-driven CE/CME program led to significant positive changes in practitioners’ self-efficacy and implementation of integrative care practices in PC settings. The results indicate that CE/CME can have measurable impacts that benefit providers and may potentially impact patients, families and the culture of care.
Potential and challenges of underground CO2 storage via in-situ mineralization in Switzerland
Authors: Martin Adrian , Becattini Viola , Marieni Chiara , Kolbeinsdóttir Salka , Mazzotti Marco , Gunatilake Thanushika 
Published: January 2025

Abstract
Carbon Capture and Storage (CCS) technologies play a critical role in achieving global and Swiss climate goals, particularly with Switzerland aiming to domestically store some of its residual CO2 emissions. In situ mineralization presents a promising avenue for stable and permanent CO2 sequestration. This study aims to evaluate the potential of CO2 storage via in situ mineralization in the Swiss underground. A set of technical/geological criteria was defined and used to identify, evaluate, and classify the various geological formations. The selected areas identified and evaluated include alpine tectonic units with large volumes of mafic and ultramafic rocks. Despite the presence of suitable rock types, these units are marked by alpine deformation with highly complex structures, rock mixtures, and complex bedrock hydrogeology. The old, altered, and metamorphic nature of the alpine mafic and ultramafic rock formations results in minimal permeability and porosity, consequently impeding CO2 injectivity and mineralization kinetics, particularly given the low average geothermal gradient. Additionally, challenges related to water resource requirements, storage site location and accessibility, financial costs, regulation, social acceptance, and environmental impacts further impact feasibility negatively. This study concludes that CO2 sequestration via in situ mineralization in the Swiss context is unfeasible in the near term and possibly unsuitable in the long one.
Comparative analysis of HKTs in six poplar species and functional characterization of PyHKTs in stress-affected tissues
Authors: Liu Xiaojiao , Shi Lincui , Bai Hezi , Wang Jing , Yu Anmin , Liu Aizhong , Li Ping 
Published: January 2025

AbstractPlant HKTs (High-affinity K+ transporters) are essential transporters for ion transport and homeostasis and play crucial roles in plant growth and stress responses. However, the evolution of HKTs in Populus species and their functions require further investigation. In this study, we identified 16 HKTs from six Populus species. All poplar HKTs were classified as Class I HKTs because of their physiological relationships and the conservation of amino acids in key structures, which aligns with their conserved evolutionary coding sequences. The analysis of the protein domains, motifs and gene structures of 16 poplar HKTs revealed consistent conservation, with the exception of two members. The number of homologs and their chromosome locations indicated the differentiation of HKTs during poplar evolution and adaptation. Poplar HKTs can be classified into two subgroups on the basis of their physiological relationships and distinct protein structures. Gene expression pattern analysis revealed that poplar HKTs presented relatively high expression levels in roots and stems under salt stress. Furthermore, cis-element analysis and protein interaction predictions provide insights into the functions of HKTs under salt stress through the activation of ion transporters, proline content, and ATPases regulated by hormonal signals and MYB transcription factors. In conclusion, our research established a theoretical framework for investigating the evolutionary relationships and functional roles of HKTs in Populus species and offered valuable insights into the functions and underlying mechanisms of poplar HKTs in specific tissues under various stress conditions.
Thoracic vertebral body erosion due to a perianeurysmal outpouching lesion after thoracic endovascular aortic repair: a case report and literature review
Authors: Kim Hong Jin , Ahn Joonghyun , Ha Kee-Yong , Chang Dong-Gune 
Published: January 2025

Abstract
Background
The safety of endovascular treatment, such as thoracic endovascular aortic repair (TEVAR), for a descending thoracic aortic aneurysm has been well-established, with a reported low postoperative mortality rate but higher incidences of long-term complications such as endo-leakage, device failure, and aneurysm-related death. Based on this, we report the first case of massive thoracic vertebral body erosion due to a perianeurysmal outpouching lesion after TEVAR.

Case presentation
A 77-year-old female with a history of TEVAR due to descending thoracic aortic arch aneurysm 4 years ago was referred from the cardiovascular clinic to the spine center. The patient presented with persisting back pain, which began 3 years after TEVAR and progressively worsened. Physical examination was notable for tenderness in the upper thoracic region without any neurological deficits. Computed tomography of the aorta and thoracic spine showed bony erosion into the T5–T7 vertebral bodies. Magnetic resonance imaging of the thoracic spine confirmed a perianeurysmal outpouching lesion eroding into the T5–T7 vertebral bodies due to pulsating pressure. We performed the posterior instrumented fusion from T3 to T9 at the thoracic spine and TEVAR at remnant endo-leakage lesions.

Conclusions
Since the progression of such a condition can have a catastrophic outcome, and because the treatment options vary, serial follow-up through an interdisciplinary approach is important in cases with a high index of suspicion of a perianeurysmal outpouching lesion.
Global, regional, and national burden of anxiety disorders during the perimenopause (1990–2021) and projections to 2035
Authors: Zhang Ying , Hu Ting-Ting , Cheng Yong-Ran , Zhang Zhi-Fen , Su Jun 
Published: January 2025

Abstract
Purpose
Perimenopause is associated with an increased risk of anxiety disorders, largely due to hormonal changes affecting the body’s regulatory feedback mechanisms. This study aims to provide a comprehensive analysis of the global burden of anxiety disorders among perimenopausal women.

Methods
Data from the 2021 Global Burden of Disease (GBD) database were utilized to assess disability-adjusted life years associated with anxiety disorders linked to perimenopause. We calculated trends using the estimated average percent change, and future projections were made using the Bayesian age–period–cohort model to estimate disability-adjusted life year trends for anxiety disorders from 2022 to 2035.

Results
Between 1990 and 2021, the global age-standardized disability-adjusted life year rate for anxiety disorders among perimenopausal women increased from 625.51 (95% uncertainty interval: 429.1–891.09) to 677.15 (95% uncertainty interval: 469.45–952.72), indicating a rising trend with an estimated average percent change of 0.081 (95% confidence interval: 0.0043–0.143). Regional differences were noted, with anxiety disorder burdens varying across areas with different sociodemographic index levels. Projections suggest that by 2035, the global burden of anxiety disorders in perimenopausal women will rise to 1,180.43 per 100,000, a 40.67% increase compared with 2021 levels.

Conclusion
The burden of anxiety disorders during perimenopause is a growing global concern, with a significant increase anticipated in the coming years. Targeted prevention and intervention strategies are urgently needed to mitigate this rising burden and improve mental health outcomes during perimenopause.
Can home care work be organized to promote musculoskeletal health for workers? Results from the GoldiCare cluster randomized controlled trial
Authors: Lohne Fredrik Klæboe , Fimland Marius Steiro , Palarea-Albaladejo Javier , Mathiassen Svend Erik , Holtermann Andreas , Redzovic Skender 
Published: January 2025

Abstract

Background
Workers in home care have high sick leave rates, predominantly because of musculoskeletal pain. The Goldilocks Work Principle proposes that health should be promoted by a “just right” composition of work tasks. Weekly workloads differ substantially between home care workers, suggesting that certain workers may have workloads that are too high, impacting their musculoskeletal health. The aim of this study was to evaluate the effectiveness of a “GoldiCare” intervention redistributing weekly workloads to become more equal among the homecare workers. Outcomes were pain in the neck/shoulder and lower back, and the implementation of the intervention was also evaluated.

Methods
A 16-week cluster randomized controlled trial was conducted with 125 workers from 11 home care units, divided into six intervention units and five control units. The operation coordinators of each intervention unit were educated in the Goldilocks Work Principle and provided with a planning tool to facilitate an even distribution of high care need clients. The control group continued their usual work. Primary outcomes were pain intensity in the neck/shoulder and lower back (0 to 10). Secondary outcomes included fatigue (0 to 10), composition of physical behaviors and postures (accelerometers), adherence to the intervention (weekly usage rates of the planning tool), and performance of the intervention (percentage of workers with an even distribution of workload).

Results
The analysis showed no difference between the intervention and control groups in change in lower back pain (0.07, 95%CI[-0.29;0.43]), neck/shoulder pain (-0.06, 95%CI[-0.49;0.36]) or fatigue (0.04, 95%CI[-0.52;0.61]. No significant changes were observed in the composition of physical behaviors (p = 0.067) or postures (p = 0.080–0.131) between the two groups. The intervention was succesfully implemented in three units of the six, with adherence ranging from 82–100% across the intervention period. The remaining three units had an adherence of 0–47%. No improvement in performance was observed.

Conclusion
No significant intervention effects were observed on musculoskeletal pain, fatigue, or the composition of physical behaviors and postures. The findings suggest that the intervention was not adequately implemented within the organization. Consequently, we cannot discern whether the lack of positive results were due to poor implementation or an ineffective intervention. Results thus highlight the need for a more comprehensive understanding of organizational structures within home care to facilitate more effective implementations. The hypothetical effectiveness of a fully implemented intervention remains unknown.

Trial registration
Clinicaltrials.gov ID: NCT05487027, submitted: 03/08/2022.