bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut microbiota characteristics and its immunoregulatory role in inflammatory depression: joint clinical and animal data
Authors: Zhang Kerang , Liu Penghong , Liu Zhifen , Wang Jizhi , Wang Junyan , Gao Mingxue , Zhang Yanyan , Yang Chunxia , Zhang Ai-Xia , Li Gaizhi , Li Xinrong , Liu Sha , Liu Lixin , Sun Ning 
Published: July 2023

Abstract
Previous studies have reported that inflammatory depression is a treatment-resistant depression subtype and that disturbed gut microbiota may be the source of low-grade inflammation. But the gut microbiota’s features and its role of immunoregulation in this subtype of depression remains uncertain. We propose that Toll-like receptor 4 (TLR-4)/nuclear factor kappa-B (NF-κB) and the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signaling pathway activated by disordered gut microbiota could contribute to intestinal and central inflammation in inflammatory depression. To test this hypothesis, we performed studies in both humans and mice. Gut microbiota composition in stool, inflammation factor and short chain fatty acid (SCFAs) in plasma, inflammatory and permeability marker in intestinal mucosa were analyzed in inflammatory depression patients. Then we performed fecal microbiota transplantation (FMT) and probiotic supplement to determine whether the behavioral phenotypes were linked with disturbed gut microbiota in inflammatory depression. Compared with non-inflammatory depression and HCs, the relative abundance of Bacteroides was significantly higher, and Clostridium was lower in inflammatory depression patients. Further, we found that SCFA-producing species increased with abnormal butanoate metabolism in the inflammatory depression patients following shotgun metagenomic sequencing. After FMT, gut microbiota in inflammatory depression increased inflammatory factors, those including as hs-CRP, TLR-4, NF-κB, NLRP3, Caspase-1, Interleukin-1β (IL-1β), and iba-1. We also found that intestinal mucosal permeability increased in recipient mice with depressive and anxiety-like behaviors. Clostridium butyricum treatment can normalize the gut microbiota, repair “gut leak,” decrease peripheral and central inflammatory factors, and have an antidepressant-like effect in the mouse model inflammatory depression. Together, our study findings indicate that inflammatory depression patients have increased pro-inflammatory genera and decreased SCFA-producing genera. Gut microbiota-derived inflammatory processes mediated by TLR-4/NF-κB–NLRP3 inflammasome signaling pathway are involved in neuroinflammation in inflammatory depression.
Effect of a fermented dairy beverage on treatment-related toxicity and inflammation in locally advanced cervical cancer patients, a randomized placebo-controlled pilot study.
Authors: Castro-Eguiluz Denisse , Morales Julissa Luvián , González Merari Delgadillo , Hernández Clementina Castro , Núñez Aurora Espejel , Rubí Lesbia María Rivera , Escalona Alejandra Rueda , Mancera Christian Aguila , Thomé María Guadalupe Serna , Cetina-Pérez Lucely 
Published: July 2023

Abstract
Purpose. This study aimed to analyze the effect of a probiotic-rich fermented dairy beverage, compared to a placebo, on gastrointestinal toxicity, inflammatory response, chronic toxicity, and quality of life, in locally advanced cervical cancer (LACC) patients.
Methods. A randomized, double blind, placebo-controlled pilot study assigned LACC patients to the probiotic group (n=21) or the placebo group (n=21). Intervention with probiotic or placebo beverage began 2 weeks before treatment through 90 days after treatment. The frequency and severity of toxicity symptoms, nutritional parameters, serum cytokines, fecal calprotectin, proctopathy, and quality of life were evaluated throughout treatment.
Results.Lower frequency and severity of vomit were observed in the probiotic group compared to placebo (15% vs 40%, p=0.03). No differences were observed in the frequency of symptoms among groups, including diarrhea. A trend was observed toward lower levels of inflammatory cytokines in the probiotic group. No significant differences were observed in the development of proctopathy.
Conclusion.This study demonstrated the fermented dairy beverage’s beneficial effect on reducing the frequency and severity of vomit and a tendency to lower inflammation. Still, it did not provide benefits regarding other treatment-related toxicities, probably due to the small sample size. Trial Registration Number NCT05736315, retrospectively registered on February 16, 2023.
Big Data Intelligent Analysis Technology for the Study of Spatial and Time Trends in the Development of Large Cities
Authors: Mulyukova K. V. , Mulyukov I. V. , Kureichik V. M. 
Published: July 2023

The purpose of this research is to study modern problems and prospects for solving the processing of big data containing information about real estate, as well as the possibility of practical implementation of the methodology for processing such data arrays by designing and filling a special graphic abstraction «metahouse» on a practical example.Materials and methods. The study includes a review of bibliographic sources on the problems of big data analysis and their application in the modern field of construction of large cities. During the study, a technique for presenting data in a graphical form – abstraction was used. The mathematical basis of the technique is the use of multidimensional spaces, where measurements are the characteristics of individual objects. Computer simulation of a practical problem was applied using the C# programming language. Big data storage is based on the MongoDB server. To visualize data, a Web interface based on HTML and CSS is used.Results. In the course of the work, the main characteristics of big data were identified, and the specifics of data arrays consisting of information about real estate objects in a large city were described. When processing data consisting of information about real estate objects of a large city, certain difficulties arise. Thereby, methods for effectively solving the set practical task of processing and searching for patterns in a large data array were proposed: «metahouse» abstraction, data aggregator.Tabular data were obtained for a large city by analyzing three million records containing more than 10 data groups, with a basic set of parameters: floor, number of floors, price, area, living area, kitchen area, type, operation. A MongoDB cluster was created on several computers, each of which was working with its own data set without intermediate results.The results of the computational experiment showed that when using the graphical form (vector) of big data representation, the costs and time for interpreting mining data were reduced.Combining big data processing methods and their presentation through graphical abstraction allows getting new results from existing data sets.Conclusion. During the study, it was found that the presentation of groups of the received data in a graphic image has a number of advantages over a tabular presentation of data (a vector image is easy to scale, the ability to compare without plotting).The proposed way for visualizing big data by constructing abstract vector images is an alternative to traditional tables, allowing you to take a different look at data arrays and the results of their processing. The results obtained can be used both for the primary study of big data processing technologies and as a basis for the development of real applications in the following areas: analysis of changes in the area of houses over time, analysis of changes in the number of floors of urban development, dynamics and distribution of supply and demand, etc.
Customer Churn Prevention For E-commerce Platforms using Machine
Learning-based Business Intelligence
Authors: Shaker Reddy Pundru Chandra , Sucharitha Yadala , Vivekanand Aelgani 
Published: July 2023

Aims & Background:
Businesses in the E-commerce sector, especially those in the business-
to-consumer segment, are engaged in fierce competition for survival, trying to gain access to
their rivals' client bases while keeping current customers from defecting. The cost of acquiring new
customers is rising as more competitors join the market with significant upfront expenditures and
cutting-edge penetration strategies, making client retention essential for these organizations.

Objective:
The main objective of this research is to detect probable churning customers and prevent
churn with temporary retention measures. It's also essential to understand why the customer decided
to go away to apply customized win-back strategies.

Methodology:
Predictive analysis uses the hybrid classification approach to address the regression
and classification issues. The process for forecasting E-commerce customer attrition based on support
vector machines is presented in this paper, along with a hybrid recommendation strategy for
targeted retention initiatives. You may prevent future customer churn by suggesting reasonable offers
or services.

Results:
The empirical findings demonstrate a considerable increase in the coverage ratio, hit ratio, lift degree, precision rate, and other metrics using the integrated forecasting model.

Conclusion:
To effectively identify separate groups of lost customers and create a customer churn retention strategy, categorize the various lost customer types using the RFM principle.
THE INFLUENCE OF PEER TO PEER LENDING (P2P) AND ELECTRONIC MONEY ON INCREASING PROFITS OF MICRO SMALL AND MEDIUM ENTERPRISES (MSME) IN KUDUS REGENCY
Authors: Rhealin Hening Karatri  , Keke Tamara Fahira  , Rozaq Muhammad Yasin  
Published: July 2023

Currently, MSMEs must begin to realize the importance of various digital platform services such as peer to peer lending (P2P) and electronic money. The low number of MSME business actors in Kudus Regency compared to MSME business actors in other regencies is one of the reasons for conducting this research. In addition, there is still a lack of research on Peer to peer lending (P2P) and electronic money with the use of connecting/intervening variables. The sampling technique used purposive sampling. The data was obtained using a questionnaire distributed to 91 MSME business actors in Kudus Regency. Consumer data were analyzed using multiple regression models and path analysis with SPSS. The results show that there is a direct influence of P2P and electronic money on the increase in MSME profits, the indirect influence of P2P and electronic money on the increase in MSME profits with MSME income as intervening, as well as the direct influence of P2P and electronic money on MSME income.
SISTEM KENDALI KECEPATAN KONVEYOR DENGAN BEBAN BERUBAH BERBASIS HIBRID FUZZY LOGIC-PID
Authors: Abdillah Rizky 
Published: July 2023

Teknologi kontrol automatik sangat dibutuhkan untuk memberikan kemudahan dalam perancangan alat kontrol. Salah satu penerapannya dalam perancangan alat pengontrol kecepatan putar motor DC pada konveyor penyortir barang. Motor listrik DC adalah alat yang dapat mengubah energi listrik menjadi energi kinetik/gerak. Sebuah motor DC membutuhkan tegangan arus searah (DC) untuk beroperasi. Tujuan dari skirpsi ini yaitu membuat pengontrol kecepatan (RPM) motor DC pada konveyor penyortir barang, mengendalikan kecepatan motor DC agar tetap terjaga kestabilan meskipun dengan beban yang berubah, mengaplikasikan Hibrid Fuzzy Logic-PID pada pengendali kecepatan motor DC pada konveyor penyortir barang. Penelitian ini menggunakan 3 sensor sebagai feedback yaitu sensor kecepatan, sensor tegangan dan sensor arus. Kontrol PID dibuat dengan menggunakan PID tuner pada matlab dan mendapatkan hasil parameter Kp=0,2 Ki=0,072 Kd=0,03036. Pada fuzzy logic memiliki nilai output sebanyak 5 yaitu SK =0,2 K=0,25 Sd=0,3 B=0,35 SB=0,4. Hasil penelitian menunjukansistem dapat terealisasikan, konveyor dapat tetap stabil pada setpoint dengan beban berubah sebanyak 5 kali perubahan. Pada perbandingan metode pengontrolan PID dengan Hibrid Fuzzy Logic–PID , metode PID cepat mendapatkan nilai settling time namun terjadi overshoot yang cukup tinggi , berbeda dengan Hibrid Fuzzy Logic-PID yang mendapatkan nilai settling time yang sedikit lambat namun mendapatkan hasil overshoot yang rendah.
Research on new ways of ideological and political education in new era universities
Authors: Chen Jing 
Published: July 2023

Abstract
With the advent of the scientific and technological era, the times and the modernization of China, the requirements and goals of the Political perspective applied to undergraduate universities in the Age of Science and Technology are constantly updated, and it is of practical significance to learn from a political perspective college students in the new era of rapid development today. This paper constructs the 4C/ID learning model by finding literature and methods involved and applied in the learning process to realize political learning of college students based on Internet technology and provide some theoretical reference basis for teachers and students of relevant colleges and universities. Taking the study of new ways of political learning of college students as the theoretical basis, through the support of Internet technology, the traditional research ideas discussing the political learning of college students are analyzed, discussions are held around the new ways political level learning, and finally, the 4C/ID learning model of Political learning of college students based on Internet science is constructed. How to improve the political level learning model and open up new related learning pathways is a necessary issue that educators cannot ignore today. The study shows that the 4C/ID learning model of introducing the Internet into the study of college students at the political level technology can develop political level learning to the greatest extent. Based on Internet technology, the curriculum content system political level learning can be deeply explored to promote Xi Jinping’s idea in the new social and technological era of the healthy and vigorous development of socialist culture construction.
Military Intelligence - A View Into the Future in the Light of the War in Ukraine
Authors: Rode Anže , Pavič Lojze , Ravnak Rok 
Published: July 2023

Abstract
Military Intelligence is one of key factors that is needed for successful warfighting on all levels. It is even more important in modern complex and rapidly changing environment. Lessons learned from War in Ukraine show that timely and accurate intelligence preparation is key to achieve battlefield dominance, especially if ratio of fighting forces is fundamentally unequal. This article presents significance of military intelligence and offer insight in some foreign defense systems/ armed forces military intelligence structures in order to improve military intelligence structure in defense system of Republic of Slovenia.
Indian data on response of positive pelvic lymph nodes in carcinoma cervix patients treated with simultaneous integrated boost using volumetric modulated arc radiation therapy
Authors: Perumareddy Vaishnavi , Shivananjappa Rashmi , Geeta S N , Tiwari Richa 
Published: July 2023

Objectives
The percentage of pelvic lymph node positivity in cervical cancer patients varies from 19% in early stages to 68% in advanced cases. Thirty three percent of patients will develop recurrence within 2 years following therapy and 5-year relative survival for patients with affected regional lymph nodes is 57%. Hence, pelvic lymph nodes need to be included in the definitive plan of radiation treatment for better disease control and longer survival. With conventional radiation therapy, dose escalation was not possible because of small bowel constraints. With higher conformity of intensity modulated radiotherapy technique (IMRT), doses to pelvic and abdominal organs can be minimized. The added advantage of simultaneous integrated boost (SIB) is that high dose per fraction is delivered to the gross disease and low dose to the microscopic disease, thereby reducing the total treatment time and improving the therapeutic ratio.

Material and Methods
Forty one patients presenting to the Department of Radiation Oncology, between January 2016 and June 2017, with newly biopsy proven carcinoma cervix Stage IB to IVA were enrolled in the study and all the investigations were performed. The radiation dose was delivered using volumetric modulated arc therapy plan to a dose of 5000 cGy in 25 fractions to the whole pelvis and 5500 cGy in 25 fractions at 220 cGy per fraction to the involved nodes using SIB along with weekly cisplatin at 40 mg/m2. After completion of external beam radiation, all the patients received three fractions of brachytherapy to a total dose of 21 Gy. Acute toxicities were assessed using RTOG criteria. At 3 months after completion of treatment, all the patients had been followed up with DW MRI of abdomen and pelvis to assess the response.

Results
Of the 41 carcinoma cervix patients with significantly positive lymph nodes treated with SIB VMAT, 9.8% of the patients (4 patients) had residual nodal disease, 87.8% of the patients (36 patients) had complete response, 19.5% (8 patients) had residual disease of primary disease, and 78% (32 patients) had complete response at 3 months after completion of treatment with only Grade – I and Grade – II toxicities.

Conclusion
Treatment with SIB VMAT in carcinoma cervix patients with significant pelvic lymph nodes shows very good response with acceptable acute toxicities. But longer follow-up period is required to see if this response translates into better DFS and OS.
Association of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasis
Authors: Sethi Sunil , Kanaujia Rimjhim , Yadav Rakesh , Sharma Nandita , Dadwal Rajneesh , Chaudary Hemant , Kaur Karamjit , Saini Aastha , Malhotra Sakshi , Rathore Shivali , Bagga Rashmi 
Published: July 2023

Background
Bacterial vaginosis is a common vaginal syndrome among females, which leads to significant morbidity and complications, if left untreated. The association of bacterial vaginosis with various sexually transmitted infections has been mentioned in previous literature. However, studies on the intermediate Nugent Score are lacking. This study was planned to examine the association of sexually transmitted infections with the intermediate Nugent Score.

Materials and Methods
The study included was conducted to include females presenting with vaginal discharge, burning micturition, itching, lower abdominal pain and infertility. The Nugent scoring was used to categorize patients into those having normal flora, intermediate or bacterial vaginosis. Conventional and molecular techniques targeting Trichomonas vaginalis, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, Syphilis, Neisseria gonorrhoeae and vulvovaginal candidiasis were performed.

Results
A total of 3,531 clinical samples were collected from females with a median age of 28.0 years. The number of patients with bacterial vaginosis and intermediate Nugent Score and positive cases were significantly higher in the 21–35 years age group (P < 0.0001). We observed that the likelihood of test results being positive for Trichomonas vaginalis was higher (P < 0.05), as the abnormality of the vaginal flora increased. Mycoplasma hominis was observed to be significantly higher in the intermediate Nugent Score group than the BV-positive patients (0.6 vs 0.2, P = 0.002). The number of vulvovaginal candidiasis cases in both the bacterial vaginosis-negative and bacterial vaginosis-positive groups were nearly the same (9.3 vs 9.8%).

Limitation
Individual follow-up couldn’t be performed on the patients.

Conclusion
We observed that the dysbiosis in vaginal microbiota, with an increase in Nugent scoring, was significantly associated with an increased risk for the acquisition of sexually transmitted infections and vulvovaginal candidiasis.
Cálculo de las ecuaciones del movimiento parabólico usando Tracker
Authors: Abdel Rahim Garzón Gladys Patricia , Moreno Villate Manuel Antonio 
Published: July 2023

Estudiamos el movimiento parabólico usando dos métodos diferentes. Primero se construyó la catapulta de torsión para obtener experimentalmente el alcance máximo de 6 ángulos y segundo se utilizó Tracker para obtener el ángulo de tiro parabólico, las posiciones iniciales y finales, las gráficas posiciones y velocidades como funciones del tiempo. Con los datos tomados de la parte experimental y del Tracker hallamos: la velocidad inicial, las ecuaciones de movimiento como función del tiempo en términos de sus vectores unitarios, el alcance máximo, la altura máxima y el tiempo de vuelo usando el método tradicional. Al comparar los datos experimentales con los calculados tradicionalmente del tiempo de vuelo, el alcance máximo y la altura máxima, los errores fueron del ~ 3.9%, ~ 0.12%, y ~ 0.67% respectivamente.
Optimización de métodos de extracción de R-Ficoeritrina a partir de Porphyridium cruentum
Authors: Garza-Valverde E. , Cortez-Guardiola S.A. , Guzmán-Rodríguez M.F. , Vidales-Contreras J.A. , García-Gómez C. 
Published: July 2023

Las microalgas son productos naturales, valiosos y con potencial para cubrir las necesidades de alimentación. La R-Ficoeritrina (R-PE) es un pigmento obtenido de la microalga P. cruentum que ha ganado interés como colorante rosa en alimentos. Por lo tanto, esta investigación se enfocó en optimizar los métodos de extracción. Se utilizó Metodología de Superficie de Respuesta (RSM) con un diseño compuesto central y tres puntos centrales para evaluar la influencia del tiempo de homogenización, concentración y volumen del buffer en la obtención de R-PE y un índice de pureza (PI) alto. Los métodos evaluados fueron maceración, maceración con baño ultrasónico y maceración combinada con sonda ultrasónica. Las condiciones óptimas para maceración fueron 10 min de homogenización y 3 mL de buffer 0.1 M, para maceración con baño ultrasónico son 5 min de homogenización con 3 mL de buffer 0.1 M y para maceración con sonda ultrasónica fueron 7.9 min de homogenización con 5.7 mL de buffer 0.8 M. Los resultados mostraron el potencial de los métodos de extracción de R-PE para ser usada como colorante natural.