bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the interplay between protective measures and settings on the SARS-CoV-2 transmission using a Bayesian network
Authors: Fuster-Parra Pilar , Huguet-Torres Aina , Castro-Sánchez Enrique , Bennasar-Veny Miquel , Yañez Aina Maria 
Published: September 2023

Abstract
During the COVID-19 pandemic, primary healthcare nurses played a crucial role in contact tracing to minimize the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread. However, contact tracing data were underutilized to explore
the potential ways of virus transmission. Research on community spread, the effectiveness of individual protective measures,
and the impact of different exposure environments is limited. This study focused on the transmission of SARS-CoV-2, aiming
to describe the interplay between prevention measures and characteristics of exposure settings, using the data collated
from a national SARS-COV-2 contact tracing programme to build a Bayesian network (BN) with 11 relevant features, which
could potentially determine features with the strongest influence in SARS-CoV-2 transmission. BNs allow predictions of new
scenarios when hypothetical information is introduced, which makes them of special interest in epidemiological studies. In our
results, ventilation of the setting and time of exposure were the main factors for SARS-CoV-2 transmission. BN analysis can
help decision-makers refine public health campaigns and priorise resources for individuals at higher risk, and also provides
personalized guidance in specific protective measures for different settings or environments.
DRD1 Gene Polymorphism Predict Therapeutic Responses in Patients With Bipolar Mania Treated by Combination of Lithium and Olanzapine
Authors: Sun Fengli , Jin Haiying , Tao Hajian , Chen Haihan , Jin Weidong 
Published: September 2023

Abstract
Objective
To explore the correlation between DRD1 gene rs686 and rs4532 polymorphism and bipolar mania episode and therapeutic effect.
Methods
60 patients with bipolar mania and 40 normal healthy person as the control group were collected, and the DRD1 gene rs686 and rs4532 polymorphism were tested.The difference of rs4532 and rs686 polymorphism and normal control group was compared and correlated to efficacy of treatment with lithium carbonate combined with olanzapine in patients with bipolar mania by YMRS, HAMD and HAMA assessment in the 2nd, 4th, 6th and 8th weekend.
Results
The no statistical significance for the polymorphism difference of DRD1 gene polymorphism of rs686 and rs4532 between patients with bipolar mania and normal control. The patients group is divided into AA group and AG + GG group according to different genotypes of rs686, and also is divided into CC + CT group and TT group according to different genotypes of rs4532.At 8th weekend, YMRS score of AA group higher than that of AG + GG group (8.34 ± 1.23 vs 7.38 ± 1.20P < 0.05). The patient's early effective response rate (EERR,YMRS 2nd weekend reduction rate > 25%) and remission rate( RR,YMRS 8th weekend reduction rate ≥ 80%) are higher that in AA group. The no similar difference of rs4532 was found.
Conclusion
There is a correlation between DRD1 gene rs686 and the therapeutic effect of manic patient. The EERR and RR of rs686 genotype AG + GG group is higher than that of the AA group, suggesting that patients who may contain G alleles can obtain better treatment results.
Numerical and experimental study of energy absorption of PLA calibrated honeycomb structures under quasi-static loading
Authors: hashemi sayedshahabodin , Galehdari Seyed Ali 
Published: September 2023

Abstract
Nowadays, the design and construction of structures with the ability to withstand impact and control energy is of great importance to save human life or equipment. Honeycomb shock absorber structures are the best type of shock absorber due to their low density, high energy efficiency and absorption capacity, low cost and weight. In this research, the energy absorption of the honeycomb structure calibrated from polylactic acid (PLA) has been investigated numerically and experimentally. The studied honeycomb structure was made by a 3D printer after modeling in Autodesk Inventor software. To extract the mechanical properties of PLA material, a dumbbell-shaped model was made for experimental tensile testing, and then numerical simulation was performed in Abaqus software using a quasi-static method and the results were extracted. Analytical review has also been done. The amount of energy absorption of the structure under compressive loading was calculated experimentally using a pressure testing machine, which was obtained in the experimental and numerical analysis, the values of 45 and 42 joules were obtained, respectively. Based on this research, in addition to validating the simulation of the graduated honeycomb structure made of PLA, Also, the main cause of the collapse of the structure has been confirmed. From this structure, in quasi-static loading conditions, it can be expected to have significant energy absorption compared to the same graded sample made of aluminum, and it is introduced as a cost-effective alternative to compression bearings.
Maternal Abnormal Liver Function in Early Pregnancy and Spontaneous Pregnancy Loss: A Retrospective Cohort Study
Authors: Yang Huibin , Tang Tianyi , Zhang Xiaohua , Liu Yinan , Zhou Xiaoyan , Zhang Yanling , Chen Xiaotian , Jin Longmei 
Published: September 2023

Abstract

Background
Spontaneous pregnancy loss (SPL) precedes an increased risk of reduced fertility, while its etiology mechanism remains largely unknown. Liver dysfunction presenting in early pregnancy may represent a pre-existing undiagnosed liver condition affecting foetal development. As a common but easily to be neglected metabolic disorder, little is known about whether and how maternal abnormal liver function in early pregnancy contribute to the incidence of SPL.
Methods
This is retrospective cohort study included 10175 pregnant womenwho were leveraged from the Maternal Health Care Information System (MHCIS) in Shanghai City from Jan 2017 to Dec 2021. Maternal liver dysfunction status was defined as having any elevated liver function biomarker levels (LFBs) at the first antenatal visit. SPL cases were defined as fetal death occurring before 28 weeks gestation. Generalized linear models with binomial family and log link function were used to estimate crude and adjusted risk ratios (aRRs) and 95% confidence intervals (CIs).
Results
Among 10175 leveraged pregnant women, 918 (9.0%) SPL cases were recorded. Maternal liver dysfunction in early pregnancy was associated with a 49% increased risk of SPL (RR 1.49, 95% CI 1.22–1.84). This positive association persisted after adjustment for covariates (aRR 1.55, 95% CI 1.26–1.92). Higher γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP) levels were also linked with increased risk of SPL in a linear fashion (aRRs per 1 standard deviation increase: 1.13, 95% CI 1.08–1.17; 1.13, 1.07–1.20, respectively). These observed positive associations remained significant even after adjustment for multiple corrections. Similar magnitudes of associations between liver dysfunction and SPL were observed in the subgroups of normal weight and overweight pregnant women.
Conclusions
We provide new evidence that maternal abnormal liver function in early pregnancy, as well as GGT and APL, predisposes to an increased risk of SPL. Primary healthcare providers may need to offer appropriate preconception counseling on the management of this modifiable risk factor in women of reproductive age.
Risk factors and outcomes of carbapenem-resistant Escherichia coli nosocomial infections in a Chinese teaching hospital: A retrospective study from 2013 to 2020
Authors: Kong Haifang , Zhang Longtao , Chen Qianqian , Yang Ling , Li Jin , Tian Bin , Hu Zhidong 
Published: September 2023

Abstract
Background: The emergence of carbapenem-resistant Escherichia coli (E. coli) strains poses a considerable challenge to global public health, but little is known about carbapenemase- producing E. coli in Tianjin, China. This study was undertaken to investigate the risk factors for infections with carbapenem-resistant E. coli (CREC) strains.
Methods We conducted a retrospective case‒control study in a tertiary teaching hospital. A total of 134 CREC clinical isolates was collected from the general hospital of Tianjin Medical University from 2013 to 2020. The control group was selected at a ratio of 1:1 from patients with nosocomial carbapenem-susceptible E. coli infections. Risk factors for nosocomial CREC infections and clinical outcomes were analyzed by univariate and multivariate analyses.
Results Multivariate analysis showed that cephalosporin exposure (odd ratio OR=2.01; 95% confidence interval [CI], 1.13-3.59; p=0.02), carbapenem exposure (OR=1.96; 95%CI, 1.10-3.50; p=0.02), glucocorticoids exposure (OR=32.45; 95%CI, 4.15-253.60; p=0.001); and surgical history (OR=3.26; 95%CI, 1.80-5.88; p＜0.001) were independent risk factors for CREC infections. The in-hospital mortality rate in the CREC group was 29.1%, and age>65 years old (OR=3.19; 95%CI, 1.29-7.90; p=0.01), carbapenem exposure (OR=3.54; 95%CI, 1.26-9.98; p=0.02), and central venous catheter insertion (OR=4.19; 95%CI, 1.70-10.31; p=0.002) were independent risk factors for in-hospital mortality in patients with CREC infections.
Conclusion Many factors were found to be involved in nosocomial CREC infections. CREC isolates were resistant to most antibiotics, and reducing the mortality of CREC needs comprehensive consideration of whether the antibiotics were used appropriately, underlying diseases and invasive operation.
An Unusual Presentation of Sinonasal Neuroendocrine Carcinoma: A case report
Authors: Singh Divyanshi , Mathur Anerudh , Chouhan Poonam , Singh Iqbal 
Published: September 2023

Abstract
Introduction: Sinonasal malignancies are rare, squamous cell carcinoma and adenocarcinoma being the most common histologies. Neuroendocrine sinonasal malignancies are even more rare.
Case Presentation: We report a case of a 71 year old who presented with a left infra-auricular swelling which was an unusual presentation for a sinonasal malignancy. Patient was subject to organ preserving surgery to reduce the morbidity.
Conclusion: The treatment modality comprised of both the chemoradiotherapy and surgery for a better prognosis.
Integrability and exact solutions of the (2+1)-dimensional variable coefficient Ito equation
Authors: Chu Jingyi , Liu Yaqing , Chen Xin 
Published: September 2023

Abstract
This paper focuses on the study of the (2+1)-dimensional Ito equation with spatially variable coefficients. The Lax integrability of the equation is confirmed by the Lax pair derived from the Bell polynomials. In addition, the Hirota bilinear form, the Bäcklund transformation and infinite conservation laws of the equation are obtained by the Bell polynomials. More importantly, the ansatz method and the Hirota bilinear method are employed to construct different types of N-soliton solutions and interaction solutions for the (2+1)-dimensional Ito equation with different coefficient functions. All these solutions are presented graphically.
Juvenile Dermatomyositis with Anti-SAE Antibodies in a Moroccan Child Associated with Pseudo-Angioedema: A Case Report
Corresponding author: Khalila NAINIA. Faculty of Medicine and Pharmacy. District: Tilila, Bp 7519 Agence Abb Agadir Al Fidia Cp80060, Agadir, Morocco. k.nainia@uiz.ac.ma / Khalila.nainia@gmail.com
Authors: Nainia Khalila , aouzal mohamed amine , ouafik imane , charhbili mariyam , bouchhab amal , daoudi abdellatif , tizki samira , chakiri radia 
Published: September 2023

Abstract
Background: Juvenile Dermatomyositis (JDM) is the leading cause of non-infectious inflammatory myopathy in children. it is a heterogeneous group of autoimmune diseases characterized by a variable combination of muscular, dermatological, and visceral involvement. Myositis-specific autoantibodies help define homogeneous subgroups with common clinical characteristics and prognosis. Anti-SAE (small ubiquitin-like modifier 1 (SUMO-1) activating enzyme) antibodies are among the most recently discovered specific autoantibodies. the presence of these antibodies is very rare, making it challenging to define clinical features and prognosis in the juvenile form. We report the first case of African patient with juvenile dermatomyositis and positive anti-SAE antibodies, and the only one reported in the word with pseudo-angioedema.
Case Report
A 5-year and 3-month-old Moroccan boy presented to the pediatric emergency department with dysphagia that had been evolving for 2 days, preceded two months earlier by facial erythema associated with fatigue, lower limb pain, difficulty walking, and progressive inflammatory polyarthralgia. On admission, the child had a heliotrope rash with predominant pseudo-angioedema on the lips, periungual telangiectasia, and Gottron's papules over the bilateral interphalangeal and metatarsophalangeal joints. He had more pronounced proximal muscle weakness in the lower limbs. He had no fever, arthritis, calcinosis, cutaneous ulcers, or lipodystrophy. Joint examination was normal, as was the pleuropulmonary examination. The electroneuromyography showed myogenic changes in all four limbs. Laboratory findings showed elevated levels of creatine phosphokinase and lactate dehydrogenase and a mild inflammatory syndrome. The electrocardiogram was normal. Only anti-SAE antibodies were positive.
He was diagnoses with juvenile dermatomyositis and received methylprednisolone bolus therapy followed by oral prednisone which was gradually tapered in combination with weekly intramuscular methotrexate. Dysphagia disappeared within 48 hours, and after two weeks, there was improvement in the muscular score and significant regression of facial angioedema. However, facial erythema persisted after two months despite local and systemic treatment.
Conclusion
We report the first African patient with anti-SAE autoantibody-positive JDM. He is the only one described with pseudo-angioedema. He had a typical dermatological, progressive myopathy, dysphagia. He had not fever, weight loss, respiratory signs, arthritis, calcinosis, cutaneous ulcers, lipodystrophy. He responded well to corticosteroid therapy and methotrexate.
A Novel Robust Detector for Cell-Free Massive MIMO System
Authors: Solanki Mitesh , Gupta Shilpi , Mashru Deepak 
Published: September 2023

Abstract
Massive MIMO increases spectral efficiency and energy efficiency in 5G by using beamforming and spatial multiplexing. It employs a centralized solution to densify a network, resulting in intercellular interference because of its cell-centric design. Massive MIMO systems enable user-centric transmission in cellular networks to overcome inter-cell interference limitations and provide macro-diversity. Massive MIMO distinguishes itself from coordinated, distributed wireless systems with its scalability and cell-free design. This article investigates the immense potential of our proposed detector, this promising technology, and practical deployment issues due to signal coprocessing's increased backhauling overhead. We propose a conjugate gradient (CG)-based detector that enables fast-er convergence and smaller approximated errors for cell-free massive MIMO systems. An analytical approach describes the asymptotic performance of a con-jugate gradient-based likelihood ascent search detector with massive antennas. A joint channel estimation and signal detection (JCD) method is also used for real-world scenarios with imperfect channel state information (CSI). As a result of simulations, our proposed detection scheme outperforms conventional detection schemes.
Behavioral Repertoire of Lahille’s Bottlenose Dolphins During the “cooperative Fishing” With Artisanal Fishers
Authors: Serpa Nathalia , Frainer Guilherme , Santos Bárbara dos , Bortolotto Guilherme A. , Moreno Ignacio B. 
Published: September 2023

Abstract
Many human cultures have been established by positive interactions with wildlife over the last centuries. Lahille’s bottlenose dolphins (Tursiops gephyreus), for example, have historically developed tactics for coastal and estuarine foraging, which sustains a fishing art known as “cooperative fishing” by traditional fishers in estuaries of southern Brazil. Using Unmanned Aerial Vehicles footage, in this study, we explored the behavior of the Lahille’s bottlenose dolphins in the Tramandaí Inlet. We focused on how their behavior repertoire was related with the frequency of net casting by fishers. Close to eight hours of aerial footage recorded from June 2017 to May 2018 were analyzed. Our observations comprise mainly dolphins foraging in the estuary inlet when fishers were present along the shoreline. Dolphins performed at least 25 clearly distinct behaviors and three types of movement patterns. A Generalized Additive Model supported that the fishers interpret a subset of this repertoire (64%) as cues for throwing their cast nets. The behavioral overview of the Lahille’s bottlenose dolphins presented here demonstrates not only a diverse repertoire for this population, but also its clear influence on fishers’ activities. It is clear that ethological, scientific and traditional perspectives should be integrated to better understand the ecological significance of this cooperative fishing, for both dolphin populations and fishers that depend on them.
Exploring Infant Physical Activity Using a Population-based Network Analysis Approach
Authors: Thelagathoti Rama Krishna , Chaudhary Priyanka , Knarr Brian , Schenkelberg Michaela , Ali Hesham H. , Dinkel Danae 
Published: September 2023

AbstractBackground Physical activity (PA) is an important aspect of infant development and has been shown to have long-term effects on health and well-being. Accurate analysis of infant PA is crucial for understanding their physical development, monitoring health and wellness, as well as identifying areas for improvement. However, individual analysis of infant PA can be challenging and often leads to biased results due to an infant’s inability to self-report and constantly changing posture and movement. This manuscript explores a population-based network analysis approach to study infants' PA. The network analysis approach allows us to draw conclusions that are generalizable to the entire population and to identify trends and patterns in PA levels. Methods This study aims to analyze the PA of infants aged 6–15 months using accelerometer data. A total of 21 infants from different types of childcare settings were recruited, including home-based and center-based care. Each infant wore an accelerometer for four days (2 weekdays, 2 weekend days). Data were analyzed using a network analysis approach, exploring the relationship between PA and various demographic and social factors. Results The results showed that infants in center-based care have similar and significantly higher levels of PA than those in home-based care. Moreover, the ankle acceleration was much higher than the waist acceleration, and activity patterns differed on weekdays and weekends. Conclusions This study highlights the need for further research to explore the factors contributing to disparities in PA levels among infants in different childcare settings. Additionally, there is a need to develop effective strategies to promote PA among infants, considering the findings from the network analysis approach. Such efforts can contribute to enhancing infant health and well-being through targeted interventions aimed at increasing PA levels.
Prospective Affirmative Therapeutics of Cannabidiol Oil Mitigates Doxorubicin-Induced Abnormalities in Kidney Function, Inflammation, and Renal Tissue Changes.
Authors: A.Soliman Nabil , Dahmy Samih I. El , Shalaby Amr A. , Mohammed Khadija A. 
Published: September 2023

Abstract
Nephropathy is the decline in kidney function. A promising treatment for a wide range of illnesses is the use of natural materials as natural chemical compounds. The inquiry was conducted to investigate CBD's potential for renal syndrome protection. The five equal groups of fifty male Sprague-Dawley rats weighing 150 ± 25g each were shaped, Group I received distilled water administered orally, while Group II got an intraperitoneal injection of doxorubicin (18 mg/kg bwt). Group III received CBD (26mg/kg bwt) orally, while Group IV received 1 ml of CBD (26 mg/kg bwt) and Group V received Trimetazidine (10 mg/kg bwt), in addition to a single intraperitoneal dose of Doxorubicin (18 mg/kg bwt) on the 11th day for both groups (IV, V). The administration of CBD (26 mg/kg bwt) led to a noticeable improvement in oxidative stress parameters (SOD and GSH) in rats by significantly lowering enzyme activity (ALT and AST), as well as serum Creatinine and urea, (IL 6), and MDA besides the anti-inflammatory accuracy of CBD linked to significant lowering to IL6 DNA frequency concentration in line with histopathology results. As a result of its anti-inflammatory and antioxidant capabilities, cannabidiol may have protective qualities as CBD medication could be linked to controlling renal problems.
Exploring the Potential of Polyploidization as a Breeding Tool for Medicinal Plants: A Case Study on Cumin (Cuminum cyminum L.)
Authors: Hoveida Zahra Sanaei , mortazavian seyed mohammad mahdi , Norouzi Maryam , Sadat-Noori Seyed Ahmad 
Published: September 2023

Abstract
Polyploidization is a major trend in plant evolution that has many advantages over diploidization. Ploidy level manipulation is a powerful breeding tool for many plant species, including medicinal plants. Cumin (Cuminum cyminumL.), as an annual diploid plant belonging to the Apiaceae family, is the second most popular spice worldwide. To identify effective concentrations and target tissues for inducing polyploidy in cumin, three methods of seed treatment, root treatment and apical meristem treatment were tested on a cumin ecotype from South Khorasan under greenhouse conditions. Colchicine was used in varying concentrations (0.5, 0.2, 0.1, 0.05, 0.025% and 0%) for all assays. Different treatment times (12, 24, 36 and 48 hours) were considered for seed and root treatments, while the droplet method was used to treat the apical meristem. The ploidy level of the plantlets was verified by chromosome counts, flow cytometry, and cytology traits. The results showed that the seed and root treatments were not suitable for inducing polyploidy. The most effective method for inducing polyploidy in cumin was the application of colchicine (0.05%) on the apical meristem. However, applying 0.5% and 0.2% concentrations of colchicine on the apical meristem resulted in the wilting of the majority of seedlings. The tetraploid plants showed a significant difference in stomata size and pollen grain size and shape compared to the diploid mother plants.