bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular risk factors, white matter microstructure, and depressive symptoms: a longitudinal analysis in the UK Biobank
Authors: Blöchl Maria , Schaare H. Lina , Kumral Deniz , Gaebler Michael , Nestler Steffen , Villringer Arno 
Published: April 2023

AbstractBackgroundCumulative burden from vascular risk factors (VRFs) has been associated with an increased risk of depressive symptoms in mid- and later life. It has been hypothesised that this association arises because VRFs disconnect fronto-subcortical white matter tracts involved in mood regulation, which puts older adults at higher risk of developing depressive symptoms. However, evidence for the hypothesis that disconnection of white matter tracts underlies the association between VRF burden and depressive symptoms from longitudinal studies is scarce.MethodsThis preregistered study analysed longitudinal data from 6,964 middle-aged and older adults from the UK Biobank who participated in consecutive assessments of VRFs, brain imaging, and depressive symptoms. Using mediation modelling, we directly tested to what extend white matter microstructure mediates the longitudinal association between VRF burden and depressive symptoms.ResultsVRF burden showed a small association with depressive symptoms at follow-up. However, there was no evidence that fractional anisotropy (FA) of white matter tracts mediated this association. Additional analyses also yielded no mediating effects using alternative operationalisations of VRF burden, mean diffusivity (MD) of single tracts, or overall average of tract-based white matter microstructure (global FA, global MD, white matter hyperintensity volume).ConclusionsOur results lend no support to the hypothesis that disconnection of white matter tracts underlies the association between VRF burden and depressive symptoms, while highlighting the relevance of using longitudinal data to directly test pathways linking vascular and mental health.
Characterizing the clinical profile of mania without major depressive episodes: a systematic review and meta-analysis of factors associated with unipolar mania
Authors: Bartoli Francesco , Nasti Christian , Palpella Dario , Piacenti Susanna , Di Lella Maria Elisa , Mauro Stefano , Prestifilippo Luca , Crocamo Cristina , Carrà Giuseppe 
Published: April 2023

AbstractBackgroundThe diagnostic concept of unipolar mania (UM), i.e. the lifetime occurrence of mania without major depressive episodes, remains a topic of debate despite the evidence accumulated in the last few years. We carried out a systematic review and meta-analysis of observational studies testing factors associated with UM as compared to bipolar disorder with a manic-depressive course (md-BD).MethodsStudies indexed up to July 2022 in main electronic databases were searched. Random-effects meta-analyses of the association between UM and relevant correlates yielded odds ratio (OR) or standardized mean difference (SMD), with 95% confidence intervals (CIs).ResultsBased on data from 21 studies, factors positively or negatively associated with UM, as compared to md-BD, were: male gender (OR 1.47; 95% CI 1.11–1.94); age at onset (SMD −0.25; 95% CI −0.46 to −0.04); number of hospitalizations (SMD 0.53; 95% CI 0.21–0.84); family history of depression (OR 0.55; 95% CI 0.36–0.85); suicide attempts (OR 0.25; 95% CI 0.19–0.34); comorbid anxiety disorders (OR 0.35; 95% CI 0.26–0.49); psychotic features (OR 2.16; 95% CI 1.55–3.00); hyperthymic temperament (OR 1.99; 95% CI 1.17–3.40). The quality of evidence for the association with previous suicide attempts was high, moderate for anxiety disorders and psychotic features, and low or very low for other correlates.ConclusionsDespite the heterogeneous quality of evidence, this work supports the hypothesis that UM might represent a distinctive diagnostic construct, with peculiar clinical correlates. Additional research is needed to better differentiate UM in the context of affective disorders, favouring personalized care approaches.
Unpredictable robots elicit responsibility attributions
Authors: Franklin Matija , Awad Edmond , Ashton Hal , Lagnado David 
Published: April 2023

Abstract
Do people hold robots responsible for their actions? While Clark and Fischer present a useful framework for interpreting social robots, we argue that they fail to account for people's willingness to assign responsibility to robots in certain contexts, such as when a robot performs actions not predictable by its user or programmer.
How puzzling is the social artifact puzzle?
Authors: Ziemke Tom , Thellman Sam 
Published: April 2023

Abstract
In this commentary we would like to question (a) Clark and Fischer's characterization of the “social artifact puzzle” – which we consider less puzzling than the authors, and (b) their account of social robots as depictions involving three physical scenes – which to us seems unnecessarily complex. We contrast the authors' model with a more parsimonious account based on attributions.
Individual- and family-level associations between child psychopathology and parenting
Authors: Aitken Madison , Perquier Florence , Haltigan John D. , Wang Li , Andrade Brendan F. , Battaglia Marco , Szatmari Peter , Georgiades Katholiki 
Published: April 2023

AbstractParenting can protect against the development of, or increase risk for, child psychopathology; however, it is unclear if parenting is related to psychopathology symptoms in a specific domain, or to broad liability for psychopathology. Parenting differs between and within families, and both overall family-level parenting and the child-specific parenting a child receives may be important in estimating transdiagnostic associations with psychopathology. Data come from a cross-sectional epidemiological sample (N = 10,605 children ages 4–17, 6434 households). Parents rated child internalizing and externalizing symptoms and their parenting toward each child. General and specific (internalizing, externalizing) psychopathology factors, derived with bifactor modeling, were regressed on parenting using multilevel modeling. Less warmth and more aversive/inconsistent parenting in the family, and toward an individual child relative to family average, were associated with higher general psychopathology and specific externalizing problems. Unexpectedly, more warmth in the family, and toward an individual child relative to family average, was associated with higher specific internalizing problems in 4–11 (not 12–17) year-olds. Less warmth and more aversive/inconsistent parenting are broad correlates of child psychopathology. Aversive/inconsistent parenting, is also related to specific externalizing problems. Parents may behave more warmly when their younger children have specific internalizing problems, net of overall psychopathology.
Assessing unpredictability in caregiver–child relationships: Insights from theoretical and empirical perspectives
Authors: Ugarte Elisa , Hastings Paul D. 
Published: April 2023

AbstractThere has been significant interest and progress in understanding the role of caregiver unpredictability on brain maturation, cognitive and socioemotional development, and psychopathology. Theoretical consensus has emerged about the unique influence of unpredictability in shaping children’s experience, distinct from other adverse exposures or features of stress exposure. Nonetheless, the field still lacks theoretical and empirical common ground due to difficulties in accurately conceptualizing and measuring unpredictability in the caregiver–child relationship. In this paper, we first provide an overview of the role of unpredictability in theories of caregiving and childhood adversity and present four issues that are currently under-discussed but are crucial to the field. Focusing on how moment-to-moment and day-to-day dynamics are at the heart of caregiver unpredictability, we review three approaches aiming to address some of these nuances: Environmental statistics, entropy, and dynamic systems. Lastly, we conclude with a broad summary and suggest future research directions. Systematic progress in this field can inform interventions and policies aiming to increase stability in the lives of children.
Compact dual-band MIMO monopole dual-antenna system for 5G laptops
Authors: Chen Shu-Chuan , Li Kuan-Yi , Lee Chih-Kuo 
Published: April 2023

AbstractThe study aimed to present a dual-band 5G multi-input multi-output monopole dual-antenna system, which was configured on the upper edge of the display ground plane for laptops. The dual-antenna unit is a 29 × 2 × 3 mm3three-dimensional structure with two antennas of the same structure and size, consisting of a fed monopole antenna and a shorted monopole antenna. The antennas are arranged 4 mm apart, side by side in the same direction, to form a dual-antenna unit. Such a configuration allows the feeding points of the two antennas to be separated by the shorting point of the shorted monopole antenna, and the shorting point of the low-frequency resonant path (the shorted monopole antenna) of the two antennas to be larger than a quarter of the wavelength of the low frequency with appropriate bending. The strong current will be concentrated near the shorting point of the shorted monopole antenna when the low-frequency mode is excited, and the current flow from the ground to the feeding point of the other antenna will be reduced, achieving the isolation which is better than 10 dB in measurement between the two antennas without adopting any isolation element. The envelope correlation coefficients calculated from the measured complex E-field radiation patterns are all smaller than 0.12, which can cover the 5G dual-band operations of 3300–3600 and 4800–5000 MHz, and the measured antenna efficiencies can reach more than 40%, which are well suited for multiple antenna applications.
A CPW-fed dual band four-port MIMO antenna based on liquid crystal polymer for flexible IoT applications
Authors: Zhang Jie , Du Chengzhu , Pei Lingru , Liu Hongye 
Published: April 2023

AbstractA 2 × 2 dual band MIMO flexible antenna with a low profile and CPW feeding is designed for Internet of Things (IoT) domains, operating in 5G (3.3–3.6/4.8–5.0 GHz), WiMAX (5.25–5.85 GHz) and WLAN (5.15–5.35/5.725–5.825 GHz) bands. Two resonant frequencies are generated by L-shaped branches and a rectangular monopole. The mentioned MIMO antenna comprises four elements arranged vertically. With the addition of an orthogonal branch, significant isolation is attained, which exceeds 21 dB in the entire bands. The four-element MIMO antenna is fabricated and experimented to analyze the performance. According to the measurement, the antenna can operate bandwidth covering 3.156–3.84 GHz (19.55%) and 4.638–6.348 GHz (31.13%). Furthermore, the provided four-element MIMO antenna possesses a number of advantageous properties, such as ECC, DG, and TARC, indicating its suitability for 5G/WiMAX/WLAN applications. In accordance with the results of bending measurement and human body influence, it is evident that the presented liquid crystal polymer antenna could be an ideal candidate for integrating into wearable 5G/WiMAX/WLAN devices.
Abandoning the idealized white subject of legal feminism: A manifesto for silence in a Lusophone register
Authors: Heathcote Gina , Kula Lucia 
Published: April 2023

AbstractThrough an account of white feminisms and white privilege, this article examines the tensions between local and international knowledge frames. The article considers the possibility of a feminist approach to global constitutionalism and argues for a twofold critique: first, a feminist interrogation of the dominance of a specifically male history of Western and Anglo-European knowledge frames; and second, a self-critique within feminist approaches to global legal regimes that acknowledges the complicity of mainstream feminist tools in the racist histories of knowledge production. To this end, the article examines the space of gender expertise to explore how this can be both an aperture for plural feminist encounters and a refinement of diverse feminist approaches into a form digestible by the contours of international institutions. To explore alternative, decolonized encounters, the article centres Lusophone African feminist silence and action in Luanda, the capital of Angola. The article explores how Angolan gender relations, informal labour and histories of protest unsettle the frame of a feminist manifesto, to argue for a place for active silence as a methodology for undoing the status quo of global constitutional expectations of how knowledge arrives at the global and transnational levels.
The Role of Different Aspects of Communication Behavior in the Assessment of Capacity to Consent
Authors: Badenhoop Luise , Baisch Stefanie , Penger Susanne , Haberstroh Julia 
Published: April 2023

Abstract: Any medical treatment that interferes with physical integrity requires the informed consent of a patient capable of such consent. For people with dementia, the capacity to consent is questioned even in the early course of the disease. Particularly diagnostic instruments like the MacArthur Competence Assessment Tool for Treatment (MacCAT-T) often deny people with dementia the capacity to consent because of high confounding of the results with patients’ verbal abilities. To date, it remains unclear whether not only verbal but also nonverbal communication is associated with assessments of capacity to consent. The current study investigates associations between patients’ verbal and nonverbal communication behaviors as assessed by the measure for Communication Behavior in People with Dementia in Ambulant Settings (CODEMamb) and capacity to consent as assessed by the MacCAT-T. We expected the strongest positive associations for verbal communication behaviors compared to nonverbal communication behaviors. Data of N = 43 patients with dementia ( n = 8 capable of consent) were collected at two different German psychiatric clinics. The results show small to moderate correlations between the overall scores of CODEMamb and MacCAT-T. As expected, correlations were strongest for the verbal CODEMamb subscale. The results support current findings on the dependency of the MacCAT-T on verbal communication. Based on the findings, the discussion addresses how people with dementia can be enabled to make self-determined medical treatment decisions.
Multi‐Task Learning for Simultaneous Retrievals of Passive Microwave Precipitation Estimates and Rain/No‐Rain Classification
Authors: Bannai Takumi , Xu Haoyang , Utsumi Nobuyuki , Koo Eunho , Lu Keming , Kim Hyungjun 
Published: April 2023

AbstractSatellite‐based precipitation estimations provide frequent, large‐scale measurements. Deep learning has recently shown significant potential for improving estimation accuracy. Most studies have employed a two‐stage framework, which is a sequential architecture of a rain/no‐rain binary classification task followed by a rain rate regression task. This study proposes a novel precipitation retrieval framework in which these two tasks are simultaneously trained using multi‐task learning approach (MTL). Furthermore, a novel network architecture and loss function were designed to reap the benefits of MTL. The proposed two‐task model successfully achieved a better performance than the conventional single‐task model possibly due to efficient knowledge transfer between tasks. Furthermore, the product intercomparison showed that our product outperformed existing products in rain rate retrieval and also yielded better skills in the rain/no‐rain retrieval task.
Contribution of Kinetic Alfvén Waves to Energetic Electron Precipitation From the Plasma Sheet During a Substorm
Authors: Shen Yangyang , Artemyev Anton V. , Zhang Xiao‐Jia , Zou Ying , Angelopoulos Vassilis , Vasko Ivan , Runov Andrei , Tsai Ethan , Wilkins Colin 
Published: April 2023

AbstractEnergetic (≳50 keV) electron precipitation from the magnetosphere to the ionosphere during substorms can be important for magnetosphere‐ionosphere coupling. Using conjugate observations between the THEMIS, ELFIN, and DMSP spacecraft during a substorm, we have analyzed the energetic electron precipitation, the magnetospheric injection, and the associated plasma waves to examine the role of waves in pitch‐angle scattering plasma sheet electrons into the loss cone. During the substorm expansion phase, ELFIN‐A observed 50–300 keV electron precipitation from the plasma sheet that was likely driven by wave‐particle interactions. The identification of the low‐altitude extent of the plasma sheet from ELFIN is aided by DMSP global auroral images. Combining quasi‐linear theory, numerical test particle simulations, and equatorial THEMIS measurements of particles and fields, we have evaluated the relative importance of kinetic Alfvén waves (KAWs) and whistler‐mode waves in driving the observed precipitation. We find that the KAW‐driven bounce‐averaged pitch‐angle diffusion coefficients near the edge of the loss cone are ∼10−6–10−5 s−1 for these energetic electrons. The due to parallel whistler‐mode waves, observed at THEMIS ∼10‐min after the ELFIN observations, are ∼10−8–10−6 s−1. Thus, at least in this case, the observed KAWs dominate over the observed whistler‐mode waves in the scattering and precipitation of energetic plasma sheet electrons during the substorm injection.
Revised Reconstruction of the Heliospheric Modulation Potential for 1964–2022
Authors: Väisänen Pauli , Usoskin Ilya , Kähkönen Riikka , Koldobskiy Sergey , Mursula Kalevi 
Published: April 2023

AbstractGalactic cosmic rays (GCRs) impinge on the Earth's atmosphere and generate showers of secondary particles in nuclear collisions with the atmospheric constituents. The flux of GCR near Earth is subjected to heliospheric modulation driven by solar magnetic activity and to geomagnetic shielding. Variability of the GCR flux is continuously monitored by the worldwide network of ground‐based neutron monitors (NMs) since the 1950s. Solar modulation is often quantified via the force‐field approximation parameterized by the modulation potential ϕ, which can be evaluated from the global NM data set. Here we revisit the methodology and provide an updated and extended reconstruction of the heliospheric modulation potential for 1964–2022, using a recent NM yield function and the measurements of the 10 most stable high‐latitude NMs. A key improvement in the reconstructed heliospheric modulation potential is the new daily resolution, which provides new opportunities for further research. Reconstruction uses the root‐mean square error (RMSE) minimization to find the optimum daily and monthly scaling factors for individual NMs. The stability of the reconstruction is analyzed and the errors are estimated. The mean level of uncertainty is low, generally within ±1%, but it is found to depict marginal variability at the 11‐year, annual and 27‐day timescales at the <1% level, indicating that a very small systematic uncertainty is still present.
Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles
Authors: Haug Marianne , Dunder Linda , Lind P. Monica , Lind Lars , Salihovic Samira 
Published: April 2023

Abstract
Background
Perfluoroalkyl substances (PFAS) are man-made chemicals with unique properties that are widely distributed in humans and the environment. Recent studies suggest that PFAS are involved in cholesterol metabolism, however, the mechanisms underlying the associations are poorly understood.

Objective
We aimed to evaluate associations of plasma PFAS with detailed lipid and lipoprotein subfractions in an adult population of men and women.

Methods
We measured concentrations of cholesterol and triglycerides in lipoprotein subfractions, apolipoprotein subclasses, as well as fatty acid and different phospholipid measures, using serum proton nuclear magnetic resonance (1H-NMR), and four plasma PFAS using liquid chromatography-mass spectrometry (UHPLC-MS/MS). Measurements were available for 493 participants (all aged 50 years, 50% female). Multivariable linear regression was used to estimate the association of four PFAS with 43 different 1H-NMR measures, with adjustment for body mass index (BMI), smoking, education, and physical activity.

Results
We found that perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorodecanoic acid (PFDA), but not perfluorohexanesulfonate (PFHxS), concentrations were consistently positively associated with concentrations of cholesterol in lipoprotein subfractions, apolipoproteins, as well as composite fatty acid- and phospholipid profiles. The most consistent associations were found for the relationship of PFAS with total cholesterol in intermediate-density lipoprotein (IDL), across all low-density lipoprotein (LDL) subfractions and small high-density lipoprotein (HDL). Moreover, we found weak to null evidence for an association of any of the measured 13 triglyceride lipoprotein subfractions with PFAS.

Conclusions
Our results suggest that plasma PFAS concentrations are associated with cholesterol in small HDL, IDL and all LDL subfractions, as well as apolipoproteins and composite fatty acid and phospholipid profiles but to a lesser extent with triglycerides in lipoproteins. Our findings draw attention to the need for more detailed measurements of lipids across various lipoprotein subfractions and subclasses in assessing the role of PFAS in lipid metabolism.

Impact

By performing an in-depth characterization of circulating cholesterol and triglycerides in lipoprotein subfractions, apolipoprotein, fatty acid, and phospholipid concentrations, this study has expanded upon the limited literature available on the associations of plasma PFAS concentrations beyond clinical routine laboratory testing for lipids.
Feedback activation of EGFR/wild-type RAS signaling axis limits KRASG12D inhibitor efficacy in KRASG12D-mutated colorectal cancer
Authors: Feng Juanjuan , Hu Zhongwei , Xia Xinting , Liu Xiaogu , Lian Zhengke , Wang Hui , Wang Liren , Wang Cun , Zhang Xueli , Pang Xiufeng 
Published: April 2023

AbstractColorectal cancer (CRC), which shows a high degree of heterogeneity, is the third most deadly cancer worldwide. Mutational activation of KRASG12D occurs in approximately 10–12% of CRC cases, but the susceptibility of KRASG12D-mutated CRC to the recently discovered KRASG12D inhibitor MRTX1133 has not been fully defined. Here, we report that MRTX1133 treatment caused reversible growth arrest in KRASG12D-mutated CRC cells, accompanied by partial reactivation of RAS effector signaling. Through a drug-anchored synthetic lethality screen, we discovered that epidermal growth factor receptor (EGFR) inhibition was synthetic lethal with MRTX1133. Mechanistically, MRTX1133 treatment downregulated the expression of ERBB receptor feedback inhibitor 1 (ERRFI1), a crucial negative regulator of EGFR, thereby causing EGFR feedback activation. Notably, wild-type isoforms of RAS, including H-RAS and N-RAS, but not oncogenic K-RAS, mediated signaling downstream of activated EGFR, leading to RAS effector signaling rebound and reduced MRTX1133 efficacy. Blockade of activated EGFR with clinically used antibodies or kinase inhibitors suppressed the EGFR/wild-type RAS signaling axis, sensitized MRTX1133 monotherapy, and caused the regression of KRASG12D-mutant CRC organoids and cell line-derived xenografts. Overall, this study uncovers feedback activation of EGFR as a prominent molecular event that restricts KRASG12D inhibitor efficacy and establishes a potential combination therapy consisting of KRASG12D and EGFR inhibitors for patients with KRASG12D-mutated CRC.