bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hämodialyse bei Patient*innen im höheren Lebensalter – eine qualitative Interviewstudie mit einem Dialyseteam
Authors: Koisser Karin 
Published: July 2023

Zusammenfassung
Hintergrund Dialyseteams betreuen immer häufiger betagte Patient*innen mit Hämodialyse. Diese verursacht im Laufe der Behandlung vielfältige Symptome, die die Lebensqualität beträchtlich einschränken. Die Lebenszeit der betreuten Patient*innen ist durch Alter, Polymorbidität und nicht zuletzt durch die Therapie selbst begrenzt.
Forschungsziel Ziel der Untersuchung war es, herauszufinden, wie ein Team aus Nephrolog*innen und Pflegepersonen die Hämodialyse betagter Patient*innen erlebt und welchen Herausforderungen es sich bei der Betreuung und Begleitung stellen muss.
Studiendesign und Methodik Im Rahmen eines qualitativen Forschungsansatzes wurden mit 9 Mitgliedern eines Dialyseteams, das > 120 Patient*innen in der Dialyseambulanz eines Krankenhauses betreut, leitfadengestützte Interviews geführt. Die Auswertung der Transkripte erfolgte anhand einer inhaltlich-strukturierenden qualitativen Inhaltsanalyse nach Kuckartz.
Ergebnisse In jeder der 4 definierten Hauptkategorien (Prädialyse und Indikationsstellung, Beginn und Stabilisierung, Destabilisierung und Therapiezieländerung, Abschied) wurde deutlich, dass die Betreuung betagter Patient*innen ein Dialyseteam vor besondere Herausforderungen stellt. Die Mitglieder des Teams beschrieben diese in ähnlicher Weise und zeigten auf, welche Bedingungen für eine als gut erlebte Betreuung erfüllt sein sollten.
Schlussfolgerung Die Betreuung betagter Patient*innen wird von der Indikationsstellung zur Hämodialyse bis zur Beendigung der Nierenersatztherapie vom Dialyseteam als ein sensibler Prozess betrachtet, der nicht nur die individuellen Bedürfnisse und Ressourcen der Patient*innen, sondern auch die der An- und Zugehörigen einbezieht. Diesen kommt vor allem bei Therapiezieländerungen eine Schlüsselrolle zu.
Malposition of a Femoral Tunneled Dialysis Catheter through a Patent Foramen Ovale
Authors: Blackburn Anthony Finnay , Landinez Gina P. , Kerlan Robert K. , Lokken R. Peter 
Published: July 2023

AbstractPatent foramen ovale (PFO) is a common congenital abnormality of high prevalence in adults. Its clinical significance is magnified in a right-to-left shunt, where paradoxical embolism can have catastrophic outcomes involving the brain, heart, mesenteric circulation, or extremities. Right-to-left shunting through a PFO is caused by increased right atrial pressure, as seen in the setting of pulmonary artery hypertension or pulmonary embolism. This case highlights the relevance of central venous catheter placement in the setting of a PFO. While the patient did not experience clinical sequelae from line placement, she was at high risk for paradoxical embolus. Recognizing the possibility of a PFO during central venous catheter placement, especially in the setting of increased right pressures, should be a consideration of all interventional radiologists.
Massive Hemoperitoneum after Paracentesis in a Patient with Budd-Chiari Syndrome: Treated with a TIPS after Negative Arteriogram
Authors: Assael Dylan J. , Sauk Steven C. 
Published: July 2023

AbstractParacenteses are considered safe procedures; however, in patients with portal hypertension, the rapid shifts in intraabdominal pressure can prompt hemorrhage from an ectopic varix. Little literature exists on the appropriate management in this clinical setting. Here, we describe a patient with portal hypertension secondary to Budd-Chiari syndrome, presenting with massive hemoperitoneum following paracentesis. Angiography was performed, without revealing an arterial source of bleeding. Subsequently, transjugular intrahepatic portosystemic shunt placement was performed via a recanalized middle hepatic vein, reducing the patient's portosystemic gradient from 15 to 6 mm Hg. This patient developed no further signs or symptoms of bleeding and remained hemodynamically stable until discharge. Follow-up imaging confirmed patency of her shunt and resolution of her ascites, without the need for future paracentesis. This case highlights that in the absence of arterial extravasation, the possibility of ectopic variceal hemorrhage should be considered, which can be successfully treated with portosystemic shunt creation.
Measuring success: program fidelity of Queensland’s child health home visiting services. A document analysis
Authors: Latham Nicole , Young Jeanine , Wilson Josephine , Gray Michelle 
Published: July 2023

Background The Family CA.R.E. (Community-based Assistance Resourcing and Education) program was introduced in Queensland two decades ago. It aimed to redress health inequalities for infants from families experiencing specific social stressors. The program has been locally adapted over time and has not been evaluated against the original program. This study assessed the extent to which selected hospital and health services in Queensland, Australia have modified the original Family C.A.R.E. program. Methods Altheide’s model was used to facilitate a critical document analysis of policies and guidelines for adapted Family C.A.R.E. home visiting programs in use by hospital and health services (target n = 7). Results Five of seven eligible services provided service model documentation. There was low alignment with the original Family C.A.R.E. program across four of the five participating services. While the program delivered within Service 4 was highly aligned to the structure and intent of the original model, variation to the program was still evident. Importantly, four of the five participating programs were not collecting evaluation measures. Conclusions Health services have adapted the original Family C.A.R.E program format to ‘fit’ the local service environment but have largely failed to collect data to facilitate evaluation. Inability to evaluate the program leads to uncertainty about program success and benefits as well as any unintended consequences for families engaging in unevaluated home visiting programs. This study highlights the importance of monitoring program fidelity and evaluating success given the potential ramifications for this vulnerable cohort and for health service delivery.
Diastolic function in chronic kidney disease
Authors: de Simone Giovanni , Mancusi Costantino 
Published: July 2023

ABSTRACT
Chronic kidney disease (CKD) is characterized by clustered age-independent concentric left ventricular (LV) geometry, geometry-independent systolic dysfunction and age and heart rate–independent diastolic dysfunction. Concentric LV geometry is always associated with echocardiographic markers of abnormal LV relaxation and increased myocardial stiffness, two hallmarks of diastolic dysfunction. Non-haemodynamic mechanisms such as metabolic and electrolyte abnormalities, activation of biological pathways and chronic exposure to cytokine cascade and the myocardial macrophage system also impact myocardial structure and impair the architecture of the myocardial scaffold, producing and increasing reactive fibrosis and altering myocardial distensibility. This review addresses the pathophysiology of diastole in CKD and its relations with cardiac mechanics, haemodynamic loading, structural conditions, non-haemodynamic factors and metabolic characteristics. The three mechanisms of diastole will be examined: elastic recoil, active relaxation and passive distensibility and filling. Based on current evidence, we briefly provide methods for quantification of diastolic function and discuss whether diastolic dysfunction represents a distinct characteristic in CKD or a proxy of the severity of the cardiovascular condition, with the potential to be predicted by the general cardiovascular phenotype. Finally, the review discusses assessment of diastolic function in the context of CKD, with special emphasis on end-stage kidney disease, to indicate whether and when in-depth measurements might be helpful for clinical decision making in this context.
Tales from the future—nuclear cardio-oncology, from prediction to diagnosis and monitoring
Authors: Mikail Nidaa , Chequer Renata , Imperiale Alessio , Meisel Alexander , Bengs Susan , Portmann Angela , Gimelli Alessia , Buechel Ronny R , Gebhard Cathérine , Rossi Alexia 
Published: July 2023

Abstract
Cancer and cardiovascular diseases (CVD) often share common risk factors, and patients with CVD who develop cancer are at high risk of experiencing major adverse cardiovascular events. Additionally, cancer treatment can induce short- and long-term adverse cardiovascular events. Given the improvement in oncological patients’ prognosis, the burden in this vulnerable population is slowly shifting towards increased cardiovascular mortality. Consequently, the field of cardio-oncology is steadily expanding, prompting the need for new markers to stratify and monitor the cardiovascular risk in oncological patients before, during, and after the completion of treatment. Advanced non-invasive cardiac imaging has raised great interest in the early detection of CVD and cardiotoxicity in oncological patients. Nuclear medicine has long been a pivotal exam to robustly assess and monitor the cardiac function of patients undergoing potentially cardiotoxic chemotherapies. In addition, recent radiotracers have shown great interest in the early detection of cancer-treatment-related cardiotoxicity. In this review, we summarize the current and emerging nuclear cardiology tools that can help identify cardiotoxicity and assess the cardiovascular risk in patients undergoing cancer treatments and discuss the specific role of nuclear cardiology alongside other non-invasive imaging techniques.
Association of healthy sleep pattern with risk of recurrent cardiovascular events among patients with coronary heart disease
Authors: Liu Sen , Wang Yuexuan , Lu Qi , Chen Xue , Geng Tingting , Li Rui , Deng Yulei , Li Lin , Lin Xiaoyu , Ou Yunjing , Tian Qingying , Cui Guanglin , Yang Kun , Pan An , Liu Gang 
Published: July 2023

Abstract

Aims
To examine the association of a healthy sleep pattern with the risk of recurrent cardiovascular events among patients with coronary heart disease (CHD).

Methods and results
This prospective cohort study included 21 193 individuals with CHD from the UK Biobank. A healthy sleep score was generated based on a combination of chronotype, sleep duration, insomnia, and excessive daytime sleepiness. Cox proportional hazards regression models were applied to estimate the associations between healthy sleep score and recurrent cardiovascular events. During a median of 11.1 years of follow up, we documented 3771 recurrent cardiovascular events, including 1634 heart failure cases and 704 stroke cases. After multivariable adjustment, including lifestyle factors, medical history, and CHD duration, sleep 7–8 h/day, never/rarely insomnia, and no frequent daytime sleepiness were each significantly associated with a 12–22% lower risk of heart failure. In addition, compared with participants who had a healthy sleep score of 0–1, the multivariable-adjusted HR (95% CI) for participants with a healthy sleep score of 4 was 0.86 (0.75, 0.99) for recurrent cardiovascular events, 0.71 (0.57, 0.89) for heart failure, and 0.72 (0.51, 1.03) for stroke.

Conclusions
Adherence to a healthy sleep pattern was significantly associated with a lower risk of recurrent cardiovascular events among patients with CHD, especially for heart failure. These findings indicate that healthy sleep behaviours could be beneficial in the prevention of cardiovascular event recurrence.
Comprehensive regulatory networks for tomato organ development based on the genome and RNAome of MicroTom tomato
Authors: Xue Jia-Yu , Fan Hai-Yun , Zeng Zhen , Zhou Yu-Han , Hu Shuai-Ya , Li Sai-Xi , Cheng Ying-Juan , Meng Xiang-Ru , Chen Fei , Shao Zhu-Qing , Van de Peer Yves 
Published: July 2023

Abstract
MicroTom has a short growth cycle and high transformation efficiency, and is a prospective model plant for studying organ development, metabolism, and plant–microbe interactions. Here, with a newly assembled reference genome for this tomato cultivar and abundant RNA-seq data derived from tissues of different organs/developmental stages/treatments, we constructed multiple gene co-expression networks, which will provide valuable clues for the identification of important genes involved in diverse regulatory pathways during plant growth, e.g. arbuscular mycorrhizal symbiosis and fruit development. Additionally, non-coding RNAs, including miRNAs, lncRNAs, and circRNAs were also identified, together with their potential targets. Interacting networks between different types of non-coding RNAs (miRNA-lncRNA), and non-coding RNAs and genes (miRNA-mRNA and lncRNA-mRNA) were constructed as well. Our results and data will provide valuable information for the study of organ differentiation and development of this important fruit. Lastly, we established a database (http://eplant.njau.edu.cn/microTomBase/) with genomic and transcriptomic data, as well as details of gene co-expression and interacting networks on MicroTom, and this database should be of great value to those who want to adopt MicroTom as a model plant for research.
Open science in play and in tension with patent protections
Authors: Nuechterlein Anna , Rotenberg Ari , LeDue Jeff , Pavlidis Paul , Illes Judy 
Published: July 2023

Abstract
The open science (OS) movement has garnered increasing support in academia alongside continued financial and reputational incentives to obtain intellectual property (IP) protections over research outputs. Here, we explore stakeholder perspectives about intersections between OS and IP to inform the development of institutional OS guidelines for the neurosciences in Canada. We held six focus groups and three interviews with 29 faculty members from a major research and clinical center in Canada. The semi-structured interview guide probed perspectives on the respective roles of patents and OS in neuroscience-related research. We applied thematic content analysis to the transcript data, and extracted 12 major themes and 30 subthemes. Participants perceived a conflict between OS ideologies and the inherently restrictive nature of patents, and highlighted the importance of autonomy, justice, and respectful, culturally safe research practices in any future adoption of OS. Overall, the data suggest that a hybrid OS-IP policy model supported by local expertise may be best suited to meet the priorities and values of the community while mitigating perceived threats. This model includes expanded education about patenting, incentivized data sharing and collaboration, and tangible resources to support implementation of OS that includes skilled support in digital research infrastructures.
Ultra-low volume (ULV) adulticide treatment impacts age structure of Culex species (Diptera: Culicidae) in a West Nile virus hotspot
Authors: Lopez Kristina , Irwin Patrick , Bron Gebienna M , Paskewitz Susan , Bartholomay Lyric 
Published: July 2023

Abstract
West Nile virus (WNV) invaded the continental United States over 20 years ago and continues to cause yearly seasonal outbreaks of human and veterinary disease. In the suburbs of Chicago, Illinois, ultra-low volume (ULV) truck-mounted adulticide spraying frequently is performed to reduce populations of Culex restuans Theobald and Cx. pipiens L. mosquitoes (Diptera: Culicidae) in an effort to lower the risk of WNV transmission. The effectiveness of this control method has not been rigorously evaluated, and evidence for Culex population reduction after ULV adulticide spraying has been inconclusive. Therefore, we evaluated the results of 5 sequential weekly truck-mounted adulticide applications of Zenivex® E20 (etofenprox) in 2 paired sites located in Cook County, IL, during the summer of 2018. Mosquito population abundance, age structure, and WNV infection prevalence were monitored and compared between paired treatment and nearby control sites. Adulticide treatment did not result in consistent short-term or long-term reductions in target WNV vector Culex abundance. However, there was a significant increase in the proportion of nulliparous females in the treated sites compared to control sites and a decrease in Cx. pipiens WNV infection rates at one of the treated sites. This evidence that ULV adulticide spraying altered the age structure and WNV infection prevalence in a vector population has important implications for WNV transmission risk management. Our findings also underscore the importance of measuring these important indicators in addition to abundance metrics when evaluating the efficacy of control methods.
Wafer-level packaging solder joint reliability lifecycle prediction using SVR-based machine learning algorithm
Authors: Kuo Hsuan-Chen , Chang Chih-Yi , Yuan Cadmus , Chiang Kuo-Ning 
Published: July 2023

Abstract
The development of new electronic packaging structures often involves a design-on-simulation approach. However, simulation results can be subjective, and there can be variances in outcomes depending on who is conducting the simulation. To address this issue, packaging designers are now turning to machine learning to increase the accuracy and efficiency of the design process. This research study focuses on using support vector regression (SVR) techniques, such as single kernel, multiple kernels and a new SVR technique, to predict the reliability of the wafer-level packaging (WLP). By doing so, the study aims to provide designers with a reliable way to assess the reliability life cycle of their packaging designs. This research includes three steps: validating the WLP's reliability using finite element analysis (FEA) and experiment results, using the validated FEA result as input to obtain a predictive model through the SVR technique and the evaluating predictive model's performance. The results show that the predictive models developed using the SVR technique have stable performance on different testing data, which is consistent with the FEA results.
Handheld Magnetometer-Assisted Localization and Removal of a Foreign Body From the Chest Wall
Authors: Kaplan Adam J , Sheldon Rowan R 
Published: July 2023

ABSTRACT
Foreign bodies fully embedded in soft tissues present a unique challenge to surgeons attempting excision. Small fragments can be nonpalpable, and many prove difficult to visualize intra-operatively by means of classic radiologic techniques. A 35-year-old active duty soldier presented requesting excision of ballistic fragment embedded in his chest wall that had previously failed a previous attempt at removal. The metallic foreign body was successfully localized intra-operatively using a handheld magnetometer probe and removed without complication. This case demonstrates the utility and cost-effectiveness of the handheld magnetometry for intra-operative localization of metallic foreign bodies. Metallic foreign bodies may be localized intra-operatively using inexpensive and reusable equipment that does not require radiation or bulky radiographic imaging equipment.
The Effect of Age on Dengue Presentation and the Diagnostic Accuracy of the 2015 Pan American Health Organization Case Criteria in a Puerto Rican Cohort
Authors: Odio Camila D , Sánchez-González Liliana , Delorey Mark , Adams Laura E , Jones Emma S , Lorenzi Olga , Munoz-Jordan Jorge , Rivera-Amill Vanessa , Paz–Bailey Gabriela 
Published: July 2023

AbstractBackgroundWe evaluated dengue presentation by age, the performance of the 2015 Pan American Health Organization (PAHO) case criteria in identifying dengue cases, and variables to improve specificity.MethodsPatients with fever ≤7 days (N = 10 408) were recruited from 2 emergency departments from May 2012 through December 2015. Serum samples were tested for dengue, chikungunya, and nasopharyngeal swabs for respiratory viruses. Smoothing splines assessed differences in the frequencies of signs/symptoms by age. Least absolute shrinkage and selection operator regressions identified the variables that best predicted dengue.ResultsAmong 985 dengue cases, children aged &lt;5 years were least likely to have leukopenia, but most likely to have rash and petechiae. Adults had the highest odds of aches/pains and headaches/retro-orbital pain. The 2015 PAHO criteria had sensitivity of 93% and specificity of 25%. Specificity could be improved by requiring at least 2 of the following criteria: vomiting/nausea, petechiae, rash, or leukopenia (specificity 68%, sensitivity 71%) or by using 2015 PAHO criteria plus either (1) aspartate aminotransferase &gt;50 IU/L or platelet count &lt;100 000 platelets/μL (specificity 81%, sensitivity 56%) or (2) itchy skin or absence of rhinorrhea or cough (specificity 51%, sensitivity 82%).ConclusionsThe 2015 PAHO dengue case criteria had excellent sensitivity but poor specificity. This can be improved by adding signs/symptoms associated with dengue diagnosis.
Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate for Nonoccupational HIV-1 Postexposure Prophylaxis: A Prospective Open-Label Trial (DORAVIPEP)
Authors: Inciarte Alexy , Ugarte Ainoa , Martínez-Rebollar María , Torres Berta , Fernández Emma , Berrocal Leire , Laguno Montserrat , De la Mora Lorena , De Lazzari Elisa , Callau Pilar , Chivite Iván , González-Cordón Ana , Solbes Estela , Rico Verónica , Barrero Laura , Blanco José Luis , Martínez Esteban , Ambrosioni Juan , Mallolas Josep ,   for the DORAVIPEP Study Group, Inciarte Alexy , Ugarte Ainoa , Torres Berta , Martínez-Rebollar María , Laguno Montserrat , Ambrosioni Juan , Agüero Daiana , Chivite Iván , Rico Verónica , Berrocal Leire , González-Cordón Ana , Puerta Pedro , de la Mora Lorena , De Lazzari Elisa , Herrera Sabina , García-Pouton Nicol , Hernández-Meneses Marta , Monzó Patricia , Rodrigo Alonso , Callau Pilar , Aguiló Raquel , Fernández Emma , Barrero Laura , Solbes Estela , Martínez Esteban , Blanco José Luis , Miró José M , Soriano Alex , Mallolas Josep 
Published: July 2023

Abstract

Background
New regimens may provide better tolerability, convenience, and safety for nonoccupational human immunodeficiency virus (HIV) postexposure prophylaxis (PEP). For this reason, we evaluated the single-tablet regimen of doravirine/lamivudine/tenofovir disoproxil fumarate (DOR/3TC/TDF) for 28 days.

Methods
This was a prospective, open-label, single-arm trial including individuals with potential HIV-1 exposure within 72 hours. The primary endpoint was noncompletion of PEP at day 28. Secondary endpoints were adverse effects, adherence, and rate of seroconversion. We performed follow-up at day 7, week 4, and week 12.

Results
Between September 2019 and March 2022, the study enrolled 399 individuals. Median age was 30 (interquartile range [IQR], 27–36) years, and 91% (n = 364) were male. The mode of exposure was sex between men in 84% (n = 331) of cases; risk assessment for HIV-1 transmission was considered as “high” in 97% (n = 385) of the participants. Median time from exposure to consultation was 24 (IQR, 13–40) hours. Noncompletion of PEP was 29% (n = 114) (95% confidence interval [CI], 24%–33%) and 20% (n = 72) (95% CI, 16%–25%) per modified intention-to-treat. Main reasons for noncompletion were loss to follow-up (n = 104 [91%]) and intolerance (n = 8 [7%]). Older age was associated with a lower risk of premature discontinuation (OR, 0.94; P &lt; .001). One hundred twenty-three (31%) participants reported adverse events, mostly mild and self-limited (82%); discontinuation occurred in 8 cases (2%). Adherence to PEP in the assessed users was 96%. There were no HIV seroconversions.

Conclusions
DOR/3TC/TDF is a well-tolerated option for nonoccupational PEP.
Clinical Trials Registration. NCT04233372.