bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect modification of age and hypertension on cancer and prevalence of self‐reported stroke – A cross‐sectional study
Authors: Lun Ronda , Shaw Joseph R. , Roy Danielle Carole , Siegal Deborah , Ramsay Tim , Chen Yue , Dowlatshahi Dar 
Published: April 2023

AbstractThe objective of this study was to examine the effect modification of age on the relationship between cancer and prevalence of self‐reported stroke. We used cross‐sectional data from the 2015–2016 iteration of the Canadian Community Health Survey. A multivariable logistic regression model was used to assess the association between cancer and self‐reported stroke. Covariates were assessed for effect modification using the maximum likelihood estimation method. We analyzed 86,809 subjects; the prevalence of self‐reported stroke was 1.11%. The odds ratio for the association between cancer and self‐reported stroke was 1.26 (95% CI 0.98–1.61) after adjusting for age, sex, dyslipidemia, hypertension, diabetes, heart disease, education, and household income. Age and hypertension were found to be effect modifiers, and the association between cancer and self‐reported stroke was stronger in younger adults and in those without hypertension. These results suggest that cancer‐associated strokes may have unique underlying mechanisms compared to conventional strokes.
Maintenance regimen of GM‐CSF with rituximab and lenalidomide improves survival in high‐risk B‐cell lymphoma by modulating natural killer cells
Authors: Sun Shunrong , Fulati Wulipan , Shen Lin , Wu Min , Huang Zilan , Qian Wensi , Chen Pingping , Hu Yingwei , Chen Mingyue , Xu Yu , Zhang Hongdi , Ma Jiexian , Xie Yanhui 
Published: April 2023

AbstractBackgroundThe treatment of high‐risk B‐cell lymphoma (BCL) remains a challenge, especially in the elderly.MethodsA total of 83 patients (median age 65 years), who have achieved a complete response after induction therapy, were divided into two groups: R2 + GM‐CSF regimen (lenalidomide, rituximab, granulocyte‐macrophage colony‐stimulating factor [GM‐CSF]) as maintenance therapy (n = 39) and observation (n = 44). The efficacy of the R2 + GM‐CSF regimen as maintenance in patient with high‐risk BCL was analyzed and compared with observation.ResultsThe number of natural killer cells in patients increased after R2 + GM‐CSF regimen administration (0.131 × 109/L vs. 0.061 × 109/L, p = 0.0244). Patients receiving the R2 + GM‐CSF regimen as maintenance therapy had longer remission (duration of response: 18.9 vs. 11.3 months, p = 0.001), and longer progression‐free survival (not reached (NR) vs. 31.7 months, p = 0.037), and overall survival (OS) (NR vs. NR, p = 0.015). The R2 + GM‐CSF regimen was safe and well tolerated. High international prognostic index score (p = 0.012), and high tumor burden (p = 0.005) appeared to be independent prognostic factors for worse PFS.ConclusionsThe maintenance therapy of R2 + GM‐CSF regimen may improve survival in high‐risk BCL patients, which might be modulated by amplification of natural killer cells. The efficacy of the R2 + GM‐CSF maintenance regimen has to be further validated in prospective random clinical trials.
Efficacy and safety of nanoparticle albumin‐bound paclitaxel monotherapy after immune checkpoint inhibitor administration for advanced non‐small cell lung cancer: A multicenter Phase 2 clinical trial
Authors: Sonoda Tomoaki , Umeda Yukihiro , Demura Yoshiki , Tada Toshihiko , Nakashima Koki , Anzai Masaki , Yamaguchi Makiko , Shimada Akikazu , Ohi Masahiro , Honjo Chisato , Waseda Yuko , Akai Masaya , Ishizuka Tamotsu 
Published: April 2023

AbstractBackgroundWhether immunotherapy improves the efficacy or worsens adverse events of subsequent chemotherapy remains unclear. We performed a Phase 2 study to evaluate the efficacy and safety of nanoparticle albumin‐bound paclitaxel (nab‐paclitaxel) as a treatment for advanced non‐small cell lung cancer (NSCLC) after treatment with programmed cell death 1 or programmed death ligand 1 [PD‐(L)1] inhibitor failure.MethodsNab‐paclitaxel (100 mg/m2) was administered on Days 1, 8, and 15 of a 28‐day cycle to patients with advanced NSCLC within 12 weeks after the failure of PD‐(L)1 inhibitor treatment. The primary endpoint was objective response rate (ORR) in all patients; the secondary endpoints were disease control rate (DCR), progression‐free survival (PFS), overall survival (OS), and safety.ResultsThirty cases were registered, and 29 cases were included in the analysis. The ORR was 55.2% (95% confidence interval [CI]: 28.1%–79.6%) and the DCR was 86.2% (95% CI: 65.9%–97.0%). The median PFS was 5.6 months (95% CI: 4.4–6.7 months), and PFS rates at 1‐ and 2‐year timepoints were 34.5% and 13.3%, respectively. The median OS was 11.9 months (95% CI: 0.8–23.0 months). Good performance status and responder of previous PD‐(L)1 inhibitor therapy were independent predictors of PFS. Grade 3 or higher toxicities included leukopenia (27.6%), neutropenia (31.0%), peripheral sensory neuropathy (6.9%), increased alanine aminotransferase and aspartate aminotransferase levels (3.4%), and interstitial lung disease (3.4%).ConclusionsNab‐paclitaxel therapy improved ORR after PD‐(L)1 inhibitor treatment failure with a durable response of 13% and acceptable toxicities in patients with advanced NSCLC.
Pattern Recognition Analysis of Metabolites in Escherichia coli Based on ESI‐Orbitrap Mass Spectrometry
Authors: Wang Rui‐Yu , Yan Yang‐Yang , Li Bei , Fan Xing , Gu Bing , Zhou Yuan , Sun Bing‐Kang 
Published: April 2023

AbstractTo achieve rapid detection of carbapenem‐resistant Escherichia coli strains, a pattern recognition method based on electrospray ionization Orbitrap mass spectrometry (ESI‐Orbitrap MS) was used for the analysis of drug‐resistant, and sensitive strains of metabolites were analyzed. Results of five clustering methods applied to analytical data of metabolites were evaluated using iso‐phenotypic coefficients. The effectiveness of three methods, principal component analysis (PCA), partial least squares discriminant analysis (PLS‐DA) and orthogonal partial least squares discriminant analysis (OPLS‐DA), was compared. Univariate statistics such as t‐test and fold change were also used to examine the screened differential information. Both PLS‐DA and OPLS‐DA could achieve rapid identification of strain classes, and OPLS‐DA was more powerful in screening 96 significantly different ions. This work is expected to be useful for rapid and accurate identification of strains.
Variability in Chemical Composition and Antimicrobial Activity of Mentha pulegium L. Essential Oil, Cultivated under Different Plant Growth Promoting Rhizobacteria
Authors: Djerrad Zineb , Terfi Souhila , Brakchi Lila 
Published: April 2023

AbstractThe aim of present work was to study the essential oil chemical composition and antimicrobial activity of cultivated Mentha pulegium L. under different plant growth promoting rhizobacteria (Pseudomonas fluorescens, Bradyrhizobium sp. and Sinorhizobium meliloti) individually and in consortium. Yield, in plants inoculated with Bradyrhizobium sp. and S. meliloti in consortium, increase significantly relative to control plants. GC and GC/MS analyses pointed to a qualitative and quantitative variability of components. The investigated essential oils were clustered into three chemotypes: piperitenone/1,8‐cineol (40.9/29.4 %) chemotype in plants inoculated with Bradyrhizobium sp. individually, S. meliloti individually, and Bradyrhizobium sp. and S. meliloti in consortium, piperitone/menthone (41.8/33.8 %) chemotype in plants inoculated with P. fluorescens individually, P. fluorescens and Bradyrhizobium sp. in consortium, and P. fluorescens and S. meliloti in consortium and pulegone/menthol (47.9/31.5 %) chemotype in control plants. The antimicrobial activity, carried out by the disc diffusion method and the determination of the Minimum Inhibitory Concentration (MIC) against ten microorganisms, varied significantly according to the tested microorganism and the rhizobacterial species used individually or in consortium (inhibition zone: 8.5–33.5 mm; MIC: 0.25–2.5 μL/mL). Our findings provided useful indications to select interesting chemotype within M. pulegium, especially in perspective of its cultivation.
Institutional and technical history of requirements‐based strategic armor ceramics basic research leading up to the multiscale material by design materials in extreme dynamic environments (MEDE) program. Part II: Dynamic effects on the physics and mechanisms of advanced ceramics such as boron carbide
Authors: McCauley James W. , Ramesh K. T. 
Published: April 2023

AbstractThis paper follows a historical background on requirements‐based strategic armor research, leading to the materials in extreme dynamic environments program presented in Part I, now focusing on the developed technical aspects and state‐of‐the‐art. It starts with some background on dynamic testing techniques and a structural ceramics review. Then, selected armor ceramics research results and relevant single‐grain anisotropic crystal physics, microstructure, and defect mechanics mechanisms: Including pivotal armor ceramics research results prior to the adoption of the strategic research objective (SRO). Next, multiscale characteristics, crystal physics, planar features, anisotropy, and relevant mechanisms will be described. The historic progression/evolution of multiscale lightweight armor ceramics research results will be summarized, including multiscale dynamic deformation and damage characteristics. The focus of the following sections will be on the role of defects, quasi‐plasticity, and anisotropic crystal physics properties, including preexisting single grain synthesis and process‐induced planar features (aka twins) and planar deformation features (PDF); for example, nano‐amorphization in boron carbide. A new model for boron carbide processing planar features will be discussed. A schematic diagram illustrating the hypothetical formation of PDFs in a dynamic event is also presented. An expended canonical equation is introduced, suggesting possible strategies for boron carbide research using the canonical figures of merit approach. Finally, we highlight the efficacy of the materials by design process and approach in a multiscale framework for the simultaneous experimental and theoretical research trajectories guided by the accepted canonical equation.
Reversible Transition between Discrete and 1D Infinite Architectures: A Temperature‐Responsive Cu(I) Complex with a Flexible Disilane‐Bridged Bis(pyridine) Ligand
Authors: Zhao Yongjin , Nakae Toyotaka , Takeya Satoshi , Hattori Mineyuki , Saito Daisuke , Kato Masako , Ohmasa Yoshinori , Sato Shun , Yamamuro Osamu , Galica Tomasz , Nishibori Eiji , Kobayashi Shiori , Seki Tomohiro , Yamada Teppei , Yamanoi Yoshinori 
Published: April 2023

AbstractA thermoresponsive structural change based on a disilane‐bridged bis(pyridine) ligand and CuI is reported. Single‐crystal X‐ray analysis revealed that there are two polymorphs in the Cu(I) complex: octanuclear copper(I) complex at 20 °C and 1D staircase copper(I) polymer complex at −173 °C. The formation of these polymorphs is due to the flexibility of the ligand. Cu−I bond formation is observed upon cooling the sample from −10 °C to −170 °C. The temperature‐induced phase transition progression was clarified by DSC, VT‐PXRD, and VT‐photoluminescence measurements and indicated a reversible temperature‐controlled crystal‐to‐crystal phase transition. Observation on a VT‐stage using a high‐speed camera showed crystal cracking during single‐crystal to single‐crystal transitions between these polymorphic forms.
Preparation of UFM1‐Derived Probes through Highly Optimized Total Chemical Synthesis**
Authors: Chen Cong , Lu Chengpiao , Li Fang , Wang Haibo , Peng Shuai , Xu Guoqiang , Xu Hongrui , Li Jia‐Bin 
Published: April 2023

AbstractUfmylation is involved in various cellular processes and associated with many human diseases. The understanding of this modification relies on the use of customized UFM1‐derived probes for activity‐based profiling of its related enzymes. This study presents a highly optimized total chemical synthesis for the generation of diverse UFM1‐derived probes including UFM1‐PA, Biotin‐UFM1‐PA and UFM1‐AMC, in which a UFM1 C‐terminal valine hydrazide was readily prepared by hydrazide‐based ligation and used as a versatile handle for the installation of enzyme‐sensitive warheads and fluorescent reporters. The resulting probes display high reactivity and selectivity for UFM1‐specific enzymes in cell lysates. This strategy facilitates the generation and diversity of the UFM1‐derived toolkit that can be employed to profile UFM1‐specific enzymes, thereby shining insights into the dynamics of ufmylation.
Organometallic–Organic Hybrid Assemblies Featuring the Diantimony Complex [Cp2Mo2(CO)4(μ,η2‐Sb2)], AgI Ions and N‐Donor Molecules as Building Blocks
Authors: Shelyganov Pavel A. , Elsayed Moussa Mehdi , Seidl Michael , Scheer Manfred 
Published: April 2023

AbstractThe reactions of the organometallic ligand complex [Cp2Mo2(CO)4(μ,η2‐Sb2)] (C) with Ag[TEF] ([TEF]−=[Al{OC(CF3)3}4]−) in the presence of a number of di‐ or polytopic N‐donor molecules (1,6,7,12‐tetraazaperylene (L1), 2,2’‐bipyrimidine (L2), 4,4’‐bipyridine (L3), trans‐1,2‐di(4‐pyridyl)ethylene (L4) and 1,3‐di(4‐pyridyl)propane (L5)), were studied. Depending on the reaction stoichiometry and choice of linker, these reactions lead to the selective formation of dimeric or tetrameric supramolecular coordination complexes as well as 1D and 2D coordination polymers (CPs). The presented compounds are unique examples of supramolecular complexes incorporating both organometallic Sb‐donor and organic N‐donor molecules as ligands to stabilize metal ions. Moreover, one of the formed compounds, the CP [Ag4(η2 : 1‐C)4(L4)4]n[TEF]4n, represents an exceptional 1D polymer incorporating both N‐ and Sb‐donor ligands as connectors for metal ions.
Stimuli Responsive Features of Organic RTP Materials: An Intriguing Carbazole‐Cyclic Triimidazole Derivative
Authors: Malpicci Daniele , Forni Alessandra , Botta Chiara , Giannini Clelia , Lucenti Elena , Marinotto Daniele , Maver Daniele , Carlucci Lucia , Cariati Elena 
Published: April 2023

AbstractStimuli responsive luminescent materials possessing room temperature phosphorescence (RTP) are extremely desirable for various applications. The here investigated derivative of cyclic triimidazole (TT) functionalized with carbazole (Cz), namely TT‐Ph‐Cz, belongs to this class. TT‐Ph‐Cz possesses high conformational freedom resulting in rigidochromic and multi‐stimuli responsive emissive behavior. It has been isolated as MeOH‐solvated and de‐solvated forms characterized by distinctive emissive features. In particular, the solvated form, in which hydrogen bonds with MeOH inhibit competitive non‐radiative deactivation channels, possesses a higher quantum yield associated with a strong phosphorescence contribution which is preserved in DMSO/water solutions.
Interaction Modes Between SF4 and Ketones; Study of Intermediates in Deoxofluorination Reactions
Authors: Stuart Daniel , O‘Donnell Felix , Wetmore Stacey D. , Gerken Michael 
Published: April 2023

AbstractInteractions between ketones and SF4 are studied for the simplest ketone, acetone, and the bulky polycyclic 2‐adamantanone. Acetone forms the 1 : 2 adduct SF4 ⋅ [O=C(CH3)2]2, as well as the dimeric 1 : 1 adducts [SF4 ⋅ O=C(CH3)2]2 as identified by low‐temperature Raman spectroscopy and, for the latter, X‐ray crystallography. In both adducts, SF4 acts as a double chalcogen‐bond donor to two keto groups. In contrast 2‐adamantanone does not form an isolable solid adduct with SF4; in the presence of HF, however, it forms SF4 ⋅ O=C10H14O ⋅ HF, which comprises chains with weak S—O and S—FH chalcogen bonds in the crystal structure. Sulfur tetrafluoride in this compound is readily lost at −85 °C, leading to the isolation of C10H14O ⋅ HF at low temperature. Density functional theory (DFT) calculations aid in vibrational assignments and serve to describe the interactions of the keto group with SF4 and HF, as well as interactions between SF4 with HF. It is found that separate and combined CO—HF and CO—SF4 chalcogen bonds do not polarize the C=O group to any significant degree.
Development of the P‐Arylation of Dithieno[3,2‐b : 2’,3’‐d]phosphole with Aryl Iodonium Salts
Authors: Hussein Amaar , Asok Nayanthara , Béland Vanessa A. , Gaffen Joshua R. , LeBlanc Jesse , Baumgartner Thomas 
Published: April 2023

AbstractP‐Arylation of dithieno[3,2‐b : 2’,3’‐d]phosphole toward cationic phenyl phospholium species using diaryliodonium reagents was explored. Multiple conditions were tested to optimize the reaction, including variation of solvent, temperature, stoichiometry, time, and aryliodonium species employed. Initial use of diphenyliodonium chloride led to an unexpected dithienophosphole Cu(I) chloride complex that was characterized crystallographically. Alternatively, the use of diphenyliodonium hexafluorophosphate in ethanol under microwave conditions led to the successful isolation of the P‐arylated target. The phenyl dithienophospholium species exhibits blue luminescence with a quantum yield of 100 % in solution that is considerably red‐shifted in the solid state. The photophysics and solid‐state organization of the new species were compared with those of a related methyl congener, showing distinct differences that are assigned to the nature of the carbon‐based substituent at the phosphorus center, which was also confirmed by DFT calculations, and the supramolecular organization in the solid state.
Genome‐Wide Mapping of 5′ Isoforms with 5′‐Seq
Authors: Gvozdenov Zlata 
Published: April 2023

AbstractThe transcriptome is far more complex than previously assumed. Transcripts from the same gene can differ in terms of transcription start site, transcription end site, or pattern of splicing, and growing evidence supports the functional importance of these distinct transcript isoforms. Easily identifying these isoforms experimentally via library construction and high‐throughput sequencing is crucial. Current library construction methods for identifying transcription start sites (5′ transcript isoforms) involve large number of steps and (expensive) reagents, utilization of cDNA intermediates for adapter ligation, and are less suitable for studying low‐abundance isoforms. Here, I describe a quick protocol for the generation of sequencing libraries to define capped 5′ isoforms (5′‐Seq) of various abundances in yeast and suggest a 5′ isoform data analysis pipeline. The protocol relies on the utilization of a dephosphorylation‐decapping method (oligo‐capping) to generate a sequencing library from mRNA fragments and is a simplification of previously published 5′ isoform protocols in terms of the handling steps, time, and cost. This method is exemplified using Saccharomyces cerevisiae mRNA, but it can be applied to various cellular systems to study the effects of 5′ transcript isoforms on transcriptional and/or translational regulation. © 2023 Wiley Periodicals LLC.This article was corrected on 13 May 2023. See the end of the full text for details.Basic Protocol: Construction of a DNA sequencing library from capped 5′ isoformsSupport Protocol: Sequencing data analysis
Predicting vulnerability of forest patches to invasion by non‐native plants for landscape scale management
Authors: Fergus Craig , Lacher Iara L. , Herrmann Valentine , McShea William J. , Akre Thomas S. 
Published: April 2023

AbstractAs a leading cause of forest health degradation, non‐native invasive plant species are a key focus for many forest management and conservation efforts. These efforts come at a high price for resource‐limited agencies and organizations making cost‐effectiveness an important objective of invasion response plans. In this paper, we present an approach to guide the prioritization of locations for invasion management using species distribution models that account for the non‐equilibrium of invasive species distributions and use readily available land use data as the primary explanatory variables. This approach takes advantage of the relatively high spatial resolution, as well as the broad, continuous geographic coverage, of land use data to provide results at a landscape scale relevant to practitioners responsible for invasive species management. In our example from northern Virginia, we simultaneously modeled a suite of invasive plant species to identify common indicators of invasion. We found that the proportions of surrounding non‐forested land use types (grasses, crops, and development) were the most common and strongest indicators of invasion risk. These outcomes can guide managers of large protected areas to focus on major divides between forest and non‐forest land over linear disturbances. We also found useful species‐specific traits that can inform specific management actions. Additionally, we demonstrate through a case study how organizations that manage multiple smaller properties can take advantage of the projected distribution maps when considering acquiring or administering properties.
Modeling impacts of saltwater intrusion on methane and nitrous oxide emissions in tidal forested wetlands
Authors: Wang Hongqing , Dai Zhaohua , Krauss Ken W. , Trettin Carl C. , Noe Gregory B. , Burton Andrew J. , Ward Eric J. 
Published: April 2023

AbstractEmissions of methane (CH4) and nitrous oxide (N2O) from soils to the atmosphere can offset the benefits of carbon sequestration for climate change mitigation. While past study has suggested that both CH4 and N2O emissions from tidal freshwater forested wetlands (TFFW) are generally low, the impacts of coastal droughts and drought‐induced saltwater intrusion on CH4 and N2O emissions remain unclear. In this study, a process‐driven biogeochemistry model, Tidal Freshwater Wetland DeNitrification‐DeComposition (TFW‐DNDC), was applied to examine the responses of CH4 and N2O emissions to episodic drought‐induced saltwater intrusion in TFFW along the Waccamaw River and Savannah River, USA. These sites encompass landscape gradients of both surface and porewater salinity as influenced by Atlantic Ocean tides superimposed on periodic droughts. Surprisingly, CH4 and N2O emission responsiveness to coastal droughts and drought‐induced saltwater intrusion varied greatly between river systems and among local geomorphologic settings. This reflected the complexity of wetland CH4 and N2O emissions and suggests that simple linkages to salinity may not always be relevant, as non‐linear relationships dominated our simulations. Along the Savannah River, N2O emissions in the moderate‐oligohaline tidal forest site tended to increase dramatically under the drought condition, while CH4 emission decreased. For the Waccamaw River, emissions of both CH4 and N2O in the moderate‐oligohaline tidal forest site tended to decrease under the drought condition, but the capacity of the moderate‐oligohaline tidal forest to serve as a carbon sink was substantially reduced due to significant declines in net primary productivity and soil organic carbon sequestration rates as salinity killed the dominant freshwater vegetation. These changes in fluxes of CH4 and N2O reflect crucial synergistic effects of soil salinity and water level on C and N dynamics in TFFW due to drought‐induced seawater intrusion.