bluuebunny/crossref_metadata_2025_split huggingface dataset:
ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers
Authors: Redl Istvan , Fisicaro Carlo , Dutton Oliver , Hoffmann Falk , Henderson Louie , Owens Benjamin M J , Heberling Matthew , Paci Emanuele , Tamiola Kamil 
Published: May 2023

Abstract
Intrinsically disordered proteins (IDPs) are important for a broad range of biological functions and are involved in many diseases. An understanding of intrinsic disorder is key to develop compounds that target IDPs. Experimental characterization of IDPs is hindered by the very fact that they are highly dynamic. Computational methods that predict disorder from the amino acid sequence have been proposed. Here, we present ADOPT (Attention DisOrder PredicTor), a new predictor of protein disorder. ADOPT is composed of a self-supervised encoder and a supervised disorder predictor. The former is based on a deep bidirectional transformer, which extracts dense residue-level representations from Facebook’s Evolutionary Scale Modeling library. The latter uses a database of nuclear magnetic resonance chemical shifts, constructed to ensure balanced amounts of disordered and ordered residues, as a training and a test dataset for protein disorder. ADOPT predicts whether a protein or a specific region is disordered with better performance than the best existing predictors and faster than most other proposed methods (a few seconds per sequence). We identify the features that are relevant for the prediction performance and show that good performance can already be gained with &lt;100 features. ADOPT is available as a stand-alone package at https://github.com/PeptoneLtd/ADOPT and as a web server at https://adopt.peptone.io/.
DOSE ESTIMATION TO WILD MEDAKA AROUND FUKUSHIMA DAI-ICHI NUCLEAR POWER PLANT
Authors: Maruyama Kouichi , Wang Bing , Watanabe Yoshito 
Published: May 2023

Abstract
More than 10 y have passed since the Fukushima Dai-ichi Nuclear Power Plant (F1-NPP) accident, but there are still many areas with high levels of radioactive contamination, especially reservoirs and lakes, where the levels decrease slowly. The exposed dose to non-human biota is of great concern. In this work, the exposure dose to wild medaka (small aquarium fish) around F1-NPP was measured/estimated by two approaches: in situ measurement and with the ERICA assessment tool. S2 is a reservoir located 7.5 km from F1-NPP, and the ambient dose rate was 25.0 μSv per h in 2012, but decreased to 4.82 μSv per h in 2021. The external exposure dose rate to wild medaka living there was 0.8–11.8 μGy per h (2017–21) by in situ measurement, and the estimated dose rate with the ERICA assessment tool was 0.6–54.5 μGy per h (2012–21). The estimated and measured doses to wild medaka are not expected to cause any significant radiation effects.
Racialization and Reproduction: Asian Immigrants and California’s Twentieth-Century Eugenic Sterilization Program
Authors: Kaniecki Marie , Novak Nicole L , Gao Sarah , Lira Natalie , Treviño Toni Ann , O’Connor Kate , Stern Alexandra Minna 
Published: May 2023

AbstractDuring the twentieth century, state health authorities in California recommended sterilization for over 20,000 individuals held in state institutions. Asian immigrants occupied a marginalized position in racial, gender, and class hierarchies in California at the height of its eugenic sterilization program. Scholars have documented the disproportionate sterilization of other racialized groups, but little research exists connecting the racist, gendered implementation of Asian immigration restriction to the racism and sexism inherent in eugenics. This study examines patterns of coercive sterilization in Asian immigrants in California, hypothesizing higher institutionalization and sterilization rates among Asian-born compared with other foreign- and US-born individuals. We used complete count census microdata from 1910 to 1940 and digitized sterilization recommendation forms from 1920 to 1945 to model relative institutionalization and sterilization rates of Asian-born, other foreign-born, and US-born populations, stratified by gender. Other foreign-born men and women had the highest institutionalization rates in all four census years. Sterilization rates were higher for Asian-born women compared with US-born [Incidence Rate Ratio (IRR) = 2.00 (95% CI: 1.61, 2.48)] and other foreign-born women (p &lt; 0.001) across the entire study period. Sterilization rates for Asian-born men were not significantly higher than those of US-born men [IRR 0.95 (95% CI 0.83, 1.10). However, an inflection point model incorporating the year of sterilization found higher sterilization rates for Asian-born men than for US-born men prior to 1933 [IRR 1.31 (95% CI 1.09, 1.59)]. This original quantitative analysis contributes to the literature demonstrating the health impact of discrimination on Asian-Americans and the disproportionate sterilization of racial minorities under state eugenics programs.
Phytobiome Stampede: Bison as Potential Dispersal Agents for the Tallgrass Prairie Microbiome
Authors: Saleh Amgad A. , Kraisitudomsook Nattapol , Frank Erin E. , Dendy Shauna P. , Leslie John F. , Garrett Karen A. 
Published: May 2023

Dispersal by grazing and browsing animals has the potential to structure plant-associated microbes in plant communities. Bison are one of the largest grazing animals in North America and charismatic symbols of the Great Plains. They have an important role in maintaining plant communities in tallgrass prairie and may have played a significant role in microbial dispersal across the Great Plains, along with other grazers and herbivores in general. To determine whether bison saliva could maintain viable fungal propagules, we sampled saliva from bison at Konza Prairie Biological Station. Fifty-nine internal transcribed spacer sequences were recovered from distinct fungal colonies on media selective for Fusarium species and Macrophomina phaseolina, representing at least 26 fungal species. Most sequences were identified as originating from potential plant pathogens, indicating that bison may play a role in spreading plant pathogens throughout the prairie. Given their historic numbers and extensive migration across North America, bison may have had a role in establishing the current structure of the prairie microbiome. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Efficacy and Effectiveness of Wireless Binaural Beamforming Technology of Hearing Aids in Improving Speech Perception in Noise: A Systematic Review
Authors: Kumar Sathish , Guruvayurappan Ankitha , Pitchaimuthu Arivudai Nambi , Nayak Srikanth 
Published: May 2023

Objectives:
To conduct a systematic review to address the following research questions: Q1. Does wireless binaural beamforming technology perform better than conventional microphone technologies in improving the speech perception in noise abilities of individuals with hearing aids bilaterally? and Q2. Do the subjective rating scores of hearing aid benefits suggest that wireless binaural beamforming technology is better than other microphone technologies?

Design:
Two independent authors performed a comprehensive search utilizing electronic databases like PubMed, Embase, Web of Science, and Scopus. Aside from these databases, course transcripts, white papers, evidence, and field study articles from various manufacturer websites were also included. The certainty of the evidence for each outcome was determined using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines.

Results:
Eleven studies were included for the qualitative synthesis. The available data were categorized into three groups (bilateral omnidirectional, bilateral directional, and bilateral asymmetric directional microphone processing) and compared against wireless binaural beamformers. The results of the Sign test revealed that for Q1, the wireless binaural beamformer significantly outperformed the bilateral omnidirectional microphone processing. However, no significant differences were observed when compared with other groups. Results for Q2 showed no significant improvement in wireless binaural beamformers compared to other groups.

Conclusion:
The superior performance of the wireless binaural beamformers over conventional microphone technologies was demonstrated by the speech perception in noise tasks but not by the self-reported subjective ratings. Nevertheless, the evidence for both speech perception noise and subjective ratings was weak.
Vestibular Follow-up Program for Congenital Cytomegalovirus Based on 6 Years of Longitudinal Data Collection
Authors: Dhondt Cleo , Maes Leen , Van Acker Emmely , Martens Sarie , Vanaudenaerde Saartje , Rombaut Lotte , De Cuyper Elise , Van Hoecke Helen , De Leenheer Els , Dhooge Ingeborg 
Published: May 2023

Objectives:Congenital cytomegalovirus (cCMV), the leading nongenetic cause of pediatric sensorineural hearing loss, can also affect vestibular function. Literature findings suggest clinical presentation of vestibular loss in cCMV to be as variable as the hearing loss. Still, probably due to the considerable additional burden it entails for both patients and diagnostic centers, longitudinal vestibular follow-up in cCMV is not well-established in clinical practice. Therefore, this study aims to propose an evidence-based vestibular follow-up program with proper balance between its feasibility and sensitivity.Design:In this longitudinal cohort study, 185 cCMV-patients (mean age 3.2 years, SD 1.6 years, range 0.5–6.7 years) were included. Vestibular follow-up data were obtained through lateral video head impulse test (vHIT) and cervical vestibular evoked myogenic potential (cVEMP) evaluations around the ages of 6 months, 1 year, and 2 years. Around 3 and 4.5 years of age, data from vertical vHIT and ocular vestibular evoked myogenic potentials (oVEMP) were also collected.Results:At birth, 55.1% (102/185) of patients were asymptomatic and 44.9% (83/185) were symptomatic. The mean duration of follow-up for all patients was 20.8 (SD 16.3) months (mean number of follow-up assessments: 3.2, SD 1.5). Vestibular loss occurred at some point during follow-up in 16.8% (31/185) of all patients. Six percent (10/164) of patients with normal vestibular function at first assessment developed delayed-onset vestibular loss; 80.0% (8/10) of these within the first 2 years of life. Vestibular deterioration was reported both in patients who had been treated with postnatal antiviral therapy and untreated patients. At final evaluation, both the semicircular and the otolith system were impaired in the majority of vestibular-impaired ears (29/36, 80.6%). Dysfunctions limited to the semicircular system or the otolith system were reported in 4 (4/36, 11.1%) and 3 (3/36, 8.3%) ears, respectively. The occurrence of vestibular loss was highest in patients with first trimester seroconversion (16/59, 27.1%) or with an unknown timing of seroconversion (13/71, 18.3%), patients with sensorineural hearing loss (16/31, 51.6%), and patients with periventricular cysts on magnetic resonance imaging (MRI) (7/11, 63.6%).Conclusions:Longitudinal vestibular follow-up, most intensively during the first 2 years of life, is recommended in cCMV-patients with vestibular risk factors (first trimester or unknown timing of seroconversion; sensorineural hearing loss; periventricular cysts on MRI). If those risk factors can be ruled out, a single evaluation early in life (around 6 months of age) might be sufficient. Both semicircular and otolith system evaluation should be part of the follow-up program, as partial losses were reported.
Participation in an Attachment-Based Home Visiting Program Is Associated with Lower Child Salivary C-Reactive Protein Levels at Follow-Up
Authors: Londoño Tobón Amalia , Condon Eileen , Slade Arietta , Holland Margaret L. , Mayes Linda C. , Sadler Lois S. 
Published: May 2023

Abstract

Objective:
Exposure to early childhood adversity is associated with an increased risk for physiological disruption, including increased inflammation. Early interventions that support the mother-child relationship have been shown to potentially buffer negative psychosocial outcomes related to early adversity, but it is unclear whether these interventions have long-term biological effects. We evaluated whether prior participation in Minding the Baby® (MTB), an attachment-based home visiting intervention for young mother-infant dyads living in underserved communities, is associated with lower child salivary inflammatory biomarkers compared with controls at follow-up.

Methods:
Ninety-seven maternal-child dyads (n = 43 intervention and n = 54 controls) enrolled in a follow-up study of the MTB randomized controlled trial, an average of 4.6 years after RCT completion. Children provided salivary specimens. We used adjusted linear regression to examine the relationship between MTB participation and child salivary inflammatory biomarkers (C-reactive protein [CRP], interleukin [IL]-1β, IL-6, IL-8, and TNF-α).

Results:
Children were on average 6.6 years old, 48% female, and identified as non-Hispanic/Latino Black/African American (34%) and Hispanic/Latino (63%). Participation in MTB was associated with lower salivary CRP levels (β = −0.31, SE = 0.28, p = 0.003) compared with controls. Participation in MTB was not associated with salivary cytokine levels.

Discussion:
Participation in an intensive two-generation home visiting intervention such as MTB may reduce salivary inflammatory biomarkers associated with early childhood adversity. Replication and further research are needed to improve the understanding of the potential for early childhood interventions to buffer the biological embedding of early adversity.
Stellate Multiform Amelanotic Choroidopathy (SMACH). Clinical and Multimodal Imaging Features.
Authors: Ramtohul Prithvi , Pellegrini Marco , Pichi Francesco , Preziosa Chiara , Marchese Alessandro , Cicinelli Maria Vittoria , Miserocchi Elisabetta , Mundae Rusdeep , Mrejen Sarah , Rofagha Soraya , Mein Calvin E. , Mein Luke , Ober Michael D. , Cunha de Souza Eduardo , Cohen Salomon Yves , van Dijk Elon H. C. , Jampol Lee , Boon Camiel J. F. , Freund K. Bailey 
Published: May 2023

Abstract

Purpose:
To describe the clinical and multimodal imaging features of stellate multiform amelanotic choroidopathy (SMACH; also known as serous maculopathy due to aspecific choroidopathy).

Methods:
Retrospective observational case series of eyes presenting with SMACH. Multimodal imaging including fundus photography, optical coherence tomography (OCT), OCT-angiography (OCTA), and indocyanine green angiography (ICGA) was analyzed.

Results:
Eighteen eyes from 18 patients (mean age: 28±19 years) were included. The mean follow-up duration was 9 years. Ophthalmoscopy showed a yellowish-orange, dendriform choroidal lesion. At presentation, subretinal fluid (SRF) was seen in 10/18 cases (56%). Eight patients (44%) showed no evidence of SRF during a mean follow-up of 6 years. Cross-sectional OCT showed hyperreflective fibrous-like changes within the inner choroid with choriocapillaris flow preservation on OCTA. En face OCT showed a hyperreflective choroidal lesion with finger-like projections oriented in a stellate configuration. On ICGA, SMACH showed early and late hypofluorescence. None of the cases showed lesion growth.

Conclusions:
SMACH appears to be a unilateral choroidopathy characterized by distinctive multimodal imaging features. As SRF was absent in some cases, while a dendriform pattern was a consistent finding in all eyes, we propose renaming this entity “stellate multiform amelanotic choroidopathy”, a name which retains its prior abbreviation “SMACH”.
Characteristics and Related Parameters of Quick Contrast Sensitivity Function in Chinese Ametropia Children
Authors: Ye Yuhao , Xian Yiyong , Liu Fang , Lu Zhong-Lin , Zhou Xingtao , Zhao Jing 
Published: May 2023

Purpose:
To investigate the characteristics of quick contrast sensitivity function (qCSF) and its related parameters in Chinese ametropia children.

Methods:
This case series study enrolled 106 eyes of 53 children (male/female=29/24, age: 9.04±2.06 years). Examinations included manifest refraction, axial length, corneal curvature, and monocular and binocular qCSF readings without refractive correction (area under log CSF [AULCSF], CSF acuity, and contrast sensitivity [CS] at 1.0 to 18.0 cpd). The subjects were divided into groups according to age and refractive parameters for analysis.

Results:
The mean spherical equivalent (SE), AULCSF, and CSF acuity of the test eyes were −0.94±1.53 D, 0.44±0.33, and 8.50±5.97 cpd, respectively. In the monocular qCSF comparison, the refraction sphere (RS) was the major factor correlated with qCSF readings (B=0.186, P=0.009 for AULCSF; B=0.543, P=0.019 for CSF acuity; generalized linear model). The three groups stratified by RS/SE (<−1.00D, −1.00D to 0D, and >0D) showed significant differences in CS at medium spatial frequencies (3.0 and 6.0 cpd; all P<0.05). In the low RS/SE group (within −1 to 0 D), the CS at 12.0 cpd was significantly lower than that in the hyperopia group (all P<0.05). Binocular qCSF readings were significantly correlated with those of the eyes with lower RS (all P<0.05).

Conclusion:
RS and SE are the major contributing factors of qCSF without refractive correction in children. The CS at medium spatial frequencies decrease significantly as the RS/SE increase. In low myopia children, the CS at medium and high spatial frequencies are significantly decreased, providing practical value in visual function screening in children.
Comparison of Deep Anterior Lamellar Keratoplasty and Penetrating Keratoplasty in Keratoconic Eyes With Previous Hydrops-Related Corneal Scar
Authors: Kemer Atik Burcu , Emul Merve , Kirgiz Ahmet , Cubuk Mehmet Ozgur , Ahmet Sibel , Kandemir Besek Nilay 
Published: May 2023

Purpose:
This study aimed to compare the outcomes of deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) procedures in keratoconic eyes with a previous hydrops-related corneal scar.

Methods:
In this retrospective study, the medical records of patients who had hydrops-related corneal scarring and underwent keratoplasty surgery were reviewed. Patients treated with DALK were classified as group 1, and patients treated with PK as group 2. Preoperative and postoperative best-corrected visual acuity, central corneal thickness, keratometry (K), and refractive error values of each group were recorded and compared.

Results:
Seventy-eight eyes (41 in group 1 and 37 in group 2) were included in this study. The mean follow-up period of the patients was 37.7 ± 30.0 months in group 1 and 51.2 ± 29.4 months in group 2 (P = 0.06). The preoperative and postoperative best-corrected visual acuity and central corneal thickness values were statistically similar in both groups (each P value >0.05). Keratometry values (K1 and mean keratometry) were significantly steeper in group 1 (P
1 = 0.02 and P
2 = 0.03, respectively). Descemet membrane perforation was experienced in 7 (4 macroperforation and 3 microperforation; 15.6%) of 45 eyes that planned to perform DALK. These 4 eyes with macroperforation underwent PK and were excluded from the study. When all postoperative complications were assessed, although the total complication rate was 21% after DALK, it was 43% after PK (P = 0.04).

Conclusions:
DALK with a big-bubble technique is a feasible surgery in eyes with corneal scarring due to previous hydrops and is comparable with PK in terms of visual and refractive outcomes. This study suggests that DALK, which is safer than PK with less postoperative complication rates, should be the primary surgical option to avoid serious complications in keratoconic eyes with hydrops-related corneal scarring.
High Astigmatism After Conventional Diameter Deep Anterior Lamellar Keratoplasty in Keratoconus Can Be Successfully Managed With Repeat Wide Diameter Deep Anterior Lamellar Keratoplasty
Authors: Panthagani Jesse , Law Elizabeth M. , Chipeta Chimwemwe , Roberts Harry , Myerscough James 
Published: May 2023

Purpose:
The aim of this study was to describe a new surgical technique to replace a conventional diameter (≤8 mm) deep anterior lamellar keratoplasty (DALK) graft with associated high astigmatism refractory to corneal-based astigmatic procedure/intolerance to contact lenses with a larger diameter (≥9 mm) DALK graft to improve best spectacle–corrected visual acuity (BSCVA).

Methods:
Two eyes from 2 keratoconic patients at Southend University Hospital between December 2019 and June 2021 with a minimum follow-up of 17 months were evaluated. The primary outcome of interest was Snellen BSCVA with a secondary outcome of topographic cylinder.

Results:
Patient 1 had undergone initial 8 mm diameter DALK, with residual keratometric astigmatism of nearly 12 diopters (D) postoperatively despite numerous astigmatic interventions, with a BSCVA of 6/60, before undergoing 9 mm diameter repeat modified DALK. After suture removal and subsequent in-the-wound blunt manual relaxing incisions, the patient had a final keratometric astigmatism of 3.5 D, manifest refraction of plano/−3.50 × 175, and a BSCVA of 6/9. Patient 2 had undergone initial 7.75 mm diameter DALK, with residual keratometric astigmatism of 10.5 D with a BSCVA of counting fingers. The patient underwent 9 mm repeat modified DALK with final residual keratometric astigmatism of 3.1 D after suture removal, manifest refraction of −1.00/−2.75 × 25, and BSCVA of 6/9.

Conclusions:
Wide diameter DALK (>9 mm) is effective in the management of conventional diameter DALK (≤8 mm) associated high astigmatism in keratoconus. Creation of a peripheral posterior stromal shoulder also allows safe further titration of residual astigmatism if needed.
The Relationship Between Job Satisfaction and Faculty Turnover Among Physician Assistant Educators During the COVID-19 Pandemic
Authors: Lynch Shaun 
Published: May 2023

Introduction
This research explored the relationship between job satisfaction and intent to leave among physician assistant (PA) educators during the COVID-19 pandemic. Additionally, the study aimed to identify differences in PA educators' job satisfaction within gender and their intention to stay at their current employment.

Methods
A nonexperimental, cross-sectional survey was conducted with 1788 PA educators at 232 accredited programs nationally. A Web-based survey was employed to measure job satisfaction and intent to leave and to collect demographic information. Descriptive statistics were used to describe the study population, and logistic regression was used to analyze the independent variables predicting faculty turnover.

Results
PA educators were generally satisfied with their jobs (51.2%, n = 251), with the nature of the work, quality of supervision, and collegial relationships contributing the most to job satisfaction. Males were generally more satisfied with their jobs than females. More than half of the PA educators (52.4%, n = 257) considered leaving academia in the past year. Job satisfaction (odds ratio [OR] = .945, 95% confidence interval [CI] = .936-.956) and individual facets—including the nature of the work (OR = .806, 95% CI = .731-.888); communication (OR = .926, 95% CI = .860-.997); and quality of supervision (OR = .904, 95% CI = .850-.960)—were predictive of intent to leave. Gender was not found to significantly affect the relationship between job satisfaction and intent to leave.

Discussion
The findings from the study suggest the need for faculty retention to be prioritized among program and institutional leadership. PA programs need experienced leadership to develop, guide, and mentor faculty. Lastly, program and institutional leadership should create a supportive work environment that communicates clear expectations.