bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perjuangan Perempuan Kota Tomohon Pada Kontestasi Politik Lokal
Authors: Sidik Sangputri , Hasrin Awaluddin , Fathimah Siti , Hamsah Hamsah , Sasea Sanita Carolina 
Published: July 2023

This study discusses the form of political participation of women in Tomohon City. The presence of women in the Indonesian political stage is an important discourse on the progress of democracy in Indonesia. However, there are still many obstacles among women to appear in political contestation, especially in political contestation. This research shows that the trend of political participation among women in Tomohon City continues to increase. This can be seen from the presence of female mayoral candidates who ran in the contestation of the 2019 Tomohon City Elections, namely Jilly Gabriel Eman paired with Virgie Baker. In the executive area, there are at least 40% of women who position as members of the Tomohon City Parliament. Meanwhile, in the aspect of election organizers, there are women representatives in the KPU and BAWASLU of Tomohon City. This condition does not necessarily mean that the involvement of women in the world of politics goes smoothly, but there are still obstacles that must be faced by women in participating in the world of politics in Tomohon City This research also aims to always revive gender discussions in social life. Gender mainstreaming is one of the agendas that must continue to be implemented in various sectors and lines of social life, especially in the academic environment.
The Law Enforcement Towards Foreign Vessels Which Did Illegal, Unreported and Unregulated Fishing (IUU-Fishing) In Indonesia Fisheries Management Areas
Authors: Mega Jaya Belardo Prasetya , Lutfi Muhamad Uut 
Published: July 2023

Indonesia gets loss on some fields like economy, ecology, and social because of so many IUU-Fishing practices in Indonesia Fisheries Management Areas (FMA). Law enforcement is needed in handling the problem. Therefore, the aims of the research are : (1) to analyze how the law enforcement of foreign vessels which did IUU-Fishing in Indonesia Fisheries Management Areas (FMA) is inappropriate with the international law and the national law; (2) to explain how the procedure of law enforcement. This research used normative legal research. The result shows that Indonesia will act decisively every foreign vessels which did IUU-Fishing in Indonesia Fisheries Management Areas. Indonesia has enforced the law by burning and/or sinking every foreign vessel which did IUU-Fishing in Indonesian waters. Whereas in Indonesian Exclusive Economic Zone (IEEZ) would be punished by administrative sanctions and should pay a reasonable bond afterward the vessel and its crew would be deported to their country.
PROTOCOL OF ANTICOAGULATION IN EXTRACORPOREAL PURIFICATION TECHNIQUES
Authors: González-Fernández María , Quílez-Trasobares Nerea , Barea-Mendoza Jesús A. , Molina-Collado Zaira , Arias-Verdú Dolores , Barrueco-Francioni Jesús , Seller-Pérez Gemma , Herrera-Gutiérrez Manuel E. , Riera José Ángel Sánchez-Izquierdo 
Published: July 2023

Abstract
The need for anticoagulation associated with the use of extracorporeal purification techniques is one of the main concerns regarding these techniques. Although we use sodium heparin (500 IU/h) as the main anticoagulant, we assess the presence of contraindications to it, mainly associated with bleeding risk (thrombocytopenia, coagulopathy). We consider alternatives such as the use of epoprostenol or citrate, or performing EPT without anticoagulation. Furthermore, when repeated hemofilter clotting occurs (>2 sets/day), we consider changing the anticoagulation system, preferably to citrate. While we need to monitor bleeding complications when using heparin or epoprostenol, these complications are minimized with citrate as it is a regional anticoagulation system. In the latter case, we need to monitor for ionic disturbances (mainly hypocalcemia and hypomagnesemia) and electrolyte imbalances (metabolic alkalosis or acidosis due to citrate accumulation) that may occur if adequate monitoring is not carried out.
Design and development of a novel Crystal ribcage for probing real-time lung function at cellular resolution in health and disease
Authors: Banerji Rohin , Grifno Gabrielle N. , Nia Hadi T. 
Published: July 2023

Abstract
Multiple diseases impact the mechanical, biological, and immune function of the lung at the cellular scale. Despite recent progress in intravital imaging, optical imaging of the lung during active respiration and circulation has remained challenging. We introduce here the crystal ribcage: a transparent ribcage that (i) allows truly multiscale optical imaging of the lung in health and disease from whole-organ to single cell, (ii) enables modulating the lung biophysics and immunity through intravascular, intrapulmonary, intraparenchymal, and optogenetic interventions, and (iii) preserves the 3-D architecture, air-liquid interface, cellular diversity, and respiratory-circulatory functions of the lung. We probed how diseases like cancer and pneumonia progression remodels the respiratory-circulatory functions at the single alveolus and capillary levels. The crystal ribcage and its broad applications will facilitate further studies of real-time remodeling of the alveoli and capillaries during pathogenesis of nearly any pulmonary disease, leading to the identification of new targets for treatment strategies.
In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion
Authors: Vatandaslar Hasan , Tuschl Tom , Stoffel Markus 
Published: July 2023

Abstract
Here, we describe viP-CLIP (in vivo PAR-CLIP) that is capable to identify endogenous RBP targets in mammalian tissues, thereby facilitating the functional analysis of RBP-regulatory networks in vivo. Briefly, mice are exposed to 4-Thiouridine that is incorporated into newly transcribed RNAs in the organism, enabling an efficient UV-crosslinking in multiple tissues crucial for a successful experiment. We report a comprehensive protocol of the critical steps to adapt the cell culture PAR-CLIP1 protocol to the viP-CLIP protocol carried out in mice.
Exploratory Data Analysis of Earthquake Moment Tensor Catalog using Non-linear Graph-based Dimensionality Reduction
Authors: Kubo Hisahiko , Kimura Takeshi , Shiomi Katsuhiko 
Published: July 2023

Abstract
The information on spatial location, origin time and fault mechanism type of earthquakes is contained in moment tensor solutions, which are routinely estimated. The catalog of moment tensor solutions has been interpreted by researchers based on a wealth of past knowledge; however, the long-term routine analyses have led to the accumulation of a huge amount of data in moment tensor catalog, and it is necessary to move away from the artisanal approach. In this study, using dimensionality reduction of unsupervised machine learning, we performed exploratory data analysis of the moment tensor catalog to objectively obtain images of seismic activity and to acquire knowledge on the spatial and temporal characteristics of the earthquake mechanism. Source parameters of the moment tensor catalog in Japan, spatial location (latitude, longitude, and depth) and source-mechanism diagram information, were embedded in two-dimensional space via a non-linear graph-based dimensionality-reduction method, Uniform Manifold Approximation and Projection. On the embedding map, earthquakes in eastern and western Japan are distributed separately and are further embedded to reflect their characteristic fault mechanism and depth in each region. The similarity degree of the earthquakes can be obtained as the distance on the embedding map. This study demonstrates that the data visualization using dimensionality reduction is useful for intuitively and objectively understanding the regional characteristics of earthquake mechanisms. The embedding map can also be employed to visualize temporal changes in regional seismic activity, and to perform a similarity search with a past event.
Optimization of sunlight photo-catalytic treatment coupled to a coagulation-flocculation process
Authors: Raissi Sahar , fakhfakh fatma , Hadrich bilel 
Published: July 2023

Abstract
The oleic industry is one of the most polluting in food industry sector. An easy treatment of this waste is Coagulation–flocculation. Photo-catalysis can be used as complementary treatment to improve the water quality and make it reused. We optimize this method to treat mill wastewater collected from the region of Mahdia, by varying the conditions and studying their effects. Organic pollutant were removed and the final quality of water were under the imposed norm NT 106-02.
Creation of a Favorable Antitumor Microenvironment by the Anti-Complement Factor H Antibody mGT103
Authors: Saxena Ruchi , Bushey Ryan T. , Campa Michael J. , Gottlin Elizabeth B. , Guo Jian , Patz Edward F. , He You-Wen 
Published: July 2023

Abstract
Complement factor H (CFH) is an abundant serum protein regulating complement activation and protecting host cells from attack by the alternative pathway of complement mediated cytotoxicity. We previously identified an anti-CFH autoantibody in early-stage NSCLC patients, and cloned from single peripheral B cells a lead therapeutic mAb, GT103, for cancer immunotherapy. Although GT103 has potent antitumor activities, the underlying mechanisms remain unknown. Herein we investigated GT103-mediated antitumor effects and demonstrate that murine GT103 (mGT103) enhances antitumor immunity through multiple pathways. It creates a favorable tumor microenvironment (TME) by decreasing immunosuppressive regulatory T cells and myeloid-derived suppressor cells and enhancing antigen-specific effector T cells, and has a synergistic antitumor effect with anti-PD-L1 mAb. mGT103, previously shown to activate complement in vitro and in vivo, requires complement for its activity in vivo. Furthermore, the immune landscape of tumors from early-stage patients expressing the anti-CFH autoantibody is associated with an immunologically active TME. Our results provide novel mechanistic insights into this promising human-derived immunotherapeutic agent, which is currently undergoing a phase Ib clinical trial as monotherapy and a phase II combination trial with Keytruda for advanced, refractory/relapsed NSCLC patients.
Spectroscopic properties of dissolved organic matter during the wet season in the Huma River Basin, China
Authors: Zhang Daoping , Meng Fansheng , Zhang Lingsong , Wang Yeyao , Xue Hao , Liang Zhuming , Zhang Jiasheng 
Published: July 2023

Abstract
Dissolved organic matter (DOM) is the largest organic matter pool in natural waters, which is critical for ecological and societal values. The Huma River Basin (HRB) in China during the wet season presented a high background value, owning to the unusually high CODMn concentrations. To explain the phenomenon, the spectroscopic properties of DOM were studied using spectroscopic techniques combined with statistical analysis. The variations of several UV-visible parameters showed that DOM predominantly consisted of aromatic and high-molecular-weight natural organic matter. Fluorescence excitation-emission matrixes (EEMs) spectroscopy-parallel factor analysis (PARAFAC) recognized four characteristic components representing humic-like substances (C1, C2 and C3) and protein-like substances (C4). Fluorescence parameters showed that the allochthonous terrestrially-derived DOM had important humic character. Fourier transform infrared (FT-IR) spectra characterized the structure of DOM, containing aromatic, aliphatic, carbohydrate and protein compounds. Principal component analysis (PCA) revealed that humic-like components explained approximately 93.8% of the total variance. Correlation coefficient matrix analysis indicated that DOC and CODMn were mainly derived from humic-like substances. The results demonstrated that the background value in the HRB during the wet season was mainly attributed to terrestrial humic-like substances. Such knowledge could assist in monitoring and managing the river with a high background value.
N6-Methylandenosine-Related lncRNAs are Potential Biomarkers for Predicting Prognosis and Immune Response in Kidney Renal Clear Cell Carcinoma
Authors: Meng Chang , Li Juan , Wang Xiang , Ying Yicen , Li Zhihua , Wang Aixiang , Li Xuesong 
Published: July 2023

Abstract
Both lncRNAs and N6-Methylandenosine (m6A) modification have been reported as key regulators in tumorigenesis and innate immunity. This study is aimed to develop a prognostic signature based on m6A-related lncRNAs in kidney renal clear cell carcinoma (KIRC). Differential expression analysis and Pearson correlation analysis were used to identify m6A-related lncRNAs in The Cancer Genome Atlas (TCGA) database. The least absolute shrinkage and selection operator (LASSO) Cox regression analysis was applied for further selection and the selected genes were inputted into stepwise regression to develop m6A-related lncRNA risk score (MRLrisk). According to our results, MRLrisk was established based on 6 m6A-related lncRNAs, NFE4, AL008729.2, AL139123.1, LINC02154, AC124854.1 and ARHGAP31-AS1. Higher MRLrisk was identified as a risk factor for patients' prognosis in TCGA dataset as well as in subgroup analysis with different clinicopathological characteristics. Furthermore, a MRLrisk-based nomogram was developed and demonstrated as a reliable tool for prognosis prediction in KIRC. MRLrisk-related biological phenotypes were analyzed in enrichment analysis and tumor mutation signature, providing us with novel insights for further functional studies. Additionally, patients' response to immunotherapy was inferred by the tumor immune dysfunction and exclusion (TIDE) score. Results showed that higher MRLrisk may indicate worse response to immunotherapy. pRRophetic R package was used to predict patient's response to certain chemodrugs and targeted drugs. In conclusion, we developed a MRLrisk model with robust prognostic value and ability to predict immunotherapy and targeted therapy response in KIRC, which may contribute to clinical patient stratification and treatment selection for KIRC.
Effect of low-dose esketamine combined with labour analgesia on postpartum depression in spontaneous labour: a prospective case-control study
Authors: Gao Jianxin , Dai Lan , Duan Baiqing , Peng Dan , Huang Xi , He Liyunjian , Zou Jingni , Zhou Qin , Miao Dan 
Published: July 2023

Abstract
Purpose To evaluate the effect of a single intravenous low-dose esketamine combined with labour analgesia on the occurrence of postpartum depression in patients with spontaneous labour.Methods Female patients in labour were divided into a group of esketamine combined with labour analgesia (group A, n = 116), a group with labour analgesia alone (group B, n = 132) and a control group (group C, n = 51) according to the mode of analgesia. The Edinburgh Postpartum Depression Scale (EPDS) and visual analog scale (VAS) scores were collected at different time points for all three groups. Serum was also collected from patients before and after delivery to detect serum sex hormone changes.Results This clinical study was a prospective, randomised, double-blind trial. A total of 299 patients were enrolled in the study. Cross-sectional analysis showed no significant differences in EPDS scores or incidence of depression between the three groups in postpartum period, or at 1, 7 or 42 days postpartum. There were no statistically significant differences in VAS scores at 2 hours postpartum, 1 day, 2 days and 7 days postpartum. No significant differences were seen in the levels of oestrogen, progesterone, 5hydroxytryptamine and serum cortisol before delivery between the three groups. After delivery, serum cortisol levels were higher in the labour analgesia alone group than in the esketamine combined with labour analgesia group and the control group (P < 0.001). Longitudinal analysis showed that EPDS and VAS scores improved significantly over time in postpartum period for both combined esketamine and labour analgesia alone (P < 0.001), but no significant change was seen in the control group. This improvement was possibly associated with a decrease in postpartum oestrogen levels and an increase in serum cortisol levels (P < 0.001).Conclusion In this study, the combination of esketamine with labour analgesia did not reduce the incidence of depression and VAS scores at 1, 7 or 42 days postpartum.
Physicians’ attitudes towards patients with substance-related disorders predict training needs in addiction medicine: challenges and opportunities for strengthening the global addiction medicine workforce
Authors: Pinxten W. J. Lucas , Fitriana Efi , Jokūbonis Darius , Adomaitiene Virginija , Leskauskas Darius , Jong Cornelis A.J. , Hutschemaekers Giel J.M. 
Published: July 2023

Abstract
Introduction
Substance use disorders (SUD) are increasing in prevalence, and most physicians will encounter patients with SUD (PWSUD). As a result, the training of the global addiction workforce requires expansion. Two primary barriers to improving the quality and quantity of the global addiction workforce are healthcare providers' negative attitudes toward PWSUD and a lack of qualified addiction physicians. The authors are unaware of any published research on the association between these two barriers: a study that could help inform us about how to strengthen global addiction services through targeted medical training.
Methods. The MCRS, measuring professionals' attitudes towards patients with SUD, and the AM-TNA, measuring perceived training needs and competence gaps, were used to study the association between attitudes and competence. We used Pearson correlation, multiple regression, and PROCESS path analysis in a cross-sectional study design in a convenience sample of addiction physicians trained in The Netherlands (Dutch)(N = 70) and in Lithuanian (Lithuania) (N = 75) to explore this association and a possible moderation effect of the Gender and Country of Origin variables among addiction caregivers.
Results. We found a significant positive correlation between the total score of both scales: R = 0.537, p < 0.001. The MCRS predicted the three AM-TNA subscales significantly p < 0.001, and Gender did not influence the association between the two scales. The Country of Origin variable and its combination with the MCRS total score did strengthen the association between the MCRS and two AM-TNA subscales: medical- ( p < 0.001) and practical aspects of perceived addiction competence ( p < 0.05 ).
Conclusions. Attitudes predict perceived training needs, meaning addiction physicians with positive attitudes are likelier to have and want better-developed addiction knowledge and skills. To improve addiction services, the in-tandem use of the MCRS and the AM-TNA could reveal specific SUD competence gaps and model the design of an integrated addiction training or intervention approach.
Future research should focus on the longitudinal use of the combined scales, assess individual professionals’ progress, and compare and combine self-reported competencies and attitudes with validated external assessments of learning, attitudes, and self-efficacy.
Indoor environment in relation to recurrent childhood asthma in China:A Hospital-based case-control study
Authors: Zhang Baoping , Xia Zhibing , Jiang Xu , Yin Chuntao , Yuan Yang , Chen Tianming 
Published: July 2023

Abstract
Background:
This investigation explored the association between indoor environmental factors and childhood asthma in Yancheng, China.
Methods:
Asthma case (201 children with recurrent asthma) and control cohorts (242 healthy subjects) were recruited from a Traditional Chinese Medical (TCM) Hospital in Yancheng city, based on the results of an ISAAC questionnaire. Questionnaires regarding environmental risk factors were completed by the child’s primary caregivers. To compare data on environmental VOCs and formaldehyde contents between asthma and control cohorts, we passively conducted a 10-day indoor and outdoor sampling.
Results:
Breastfeeding was a major protective indoor environmental factor for recurrent asthma (adjusted odds ratio [aOR]: 0.368, 95% confidence interval[CI]: 0.216-0.627). Our analysis revealed that childhood recurrent asthma was intricately linked to a family history of asthma. Recurrent asthma was also associated with passive smoking [aOR2.115 (95%-CI 1.275-3.508)]. Analogous correlations were observed between household renovation or new furniture introduction and recurrent asthma [aOR3.129(95%-CI1.542-6.347)]. Benzene and formaldehyde were present in all examined homes. Enhanced benzene and formaldehyde concentrations were strongly evident among asthma versus control cohorts, and they were strongly correlated with augmented recurrent asthma risk.
Conclusion:
Home environment heavily regulates incidences of childhood recurrent asthma. Hence, actions against the indoor environmental risk factors described in this study may assist in the prevention of recurrent asthma among children.
Inoculating exogenous bacterium Brevibacillus laterosporus ZR-11 in compost-maturing period could accelerate composting maturation by regulating physicochemical parameters and bacterial community succession
Authors: Ren Li , Li Jieming , Li Huifen , Guo Zhonghui , Li Ji , Lv Yizhong 
Published: July 2023

Abstract

In this experiment,Brevibacillus laterosporusZR-11, a bio-control strain with resistance to Fusarium wilt in cucumber, was inoculated in the mature manure prepared for maturing composting; conventional detection and Illumina Miseq high-throughput sequencing were adopted to investigate the changes of physicochemical factors and microbial communities in the composting process; correlation analysis was also conducted, with the purpose of providing some reference for improving the production technology of biological manure and upgrading the quality of products. According to experimental results, in the maturing period, bacterial community structures underwent substantial evolutions in both the inoculated group and the non-inoculated group Microbial diversity analysis revealed that Firmicutes, Proteobacteria, and Actinobacteria were dominant bacterial phyla in both the inoculated group and the non-inoculated group in different period, but their relative abundances were higher in the former. Through analyzing physicochemical indicators, it was found that ZR-11 could increase the temperature of maturing composting pile, accelerate compost maturation, and enhance the abundance of bacterial communities in the pile. The results of this study provided some reference for improving the maturing ING composting production technology of biological manure and upgrading the quality of products.