bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic Injury in COVID-19 Patients
Authors: Al-Shalash Hadeel Tariq , Khaleel Layan Yaseen , Ahmed Shaymaa Abdullah 
Published: March 2023

The practical studies have already proved that the laboratory liver tests are highly useful in the evaluation and treatment of patients with hepatic dysfunction. It has been found that some of the enzymes and the end products of the metabolic pathway such as serum bilirubin, alanine amino transferase, aspartate amino transferase, ratio of aminotransferases, alkaline phosphatase, gamma glutamyl transferase, 5’ nucleotidase, ceruloplasmin that are very sensitive for the abnormality occurred may be considered as an outstanding biochemical marker of liver dysfunction. It is noticed that the novel coronavirus Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) infection mostly leads to respiratory distress syndrome, at the same time liver injury is also documented. As a matter of fact, the mechanism of liver injury is limited and poorly understood. Therefore, the hepatic injury might be due to a consequence of systemic inflammatory response, viral infection of hepatocytes, or it comes as a result of intensive care treatment or drug toxicity. The host angiotensin-converting enzyme 2 (ACE2) receptors, which are widely distributed in type 2 alveolar cells, are the proposed route of viral entrance. It is interesting to note that ACE2 receptors are found in the liver's cholangiocytes, vascular endothelium, and gastrointestinal tract.
Histological pictures compatible with vascular alterations are observed, characterized by the increase in number of portal vein branches associated with lumen massive dilatation, partial or complete luminal thrombosis of portal and sinusoidal vessels, fibrosis of portal tract, focally markedly enlarged and fibrotic.
ALDENOURA DE SÁ PORTO: A HISTÓRIA DE UMA EXCLUSÃO
Authors: Walker Marli Terezinha , Pinto Luiz Renato de Souza 
Published: March 2023

Resumo A exclusão de Aldenoura de Sá Porto da História da Literatura de Mato Grosso – Século XX suscita questionamentos pontuais em função da retirada da escritora do texto final da pesquisa publicada pela professora da Universidade Federal de Mato Grosso, Hilda Gomes Dutra Magalhães. Esse fato desencadeou o trabalho revisionista com o intuito de resgatar a escritora mulher do anonimato e tornar visível a produção que foi relegada ao esquecimento por uma tradição crítica que excluiu ou silenciou, ao longo da história, a produção que julgou deficitária ou inferior ao perfil de realização de obras modelares. No caso em questão, desconhecem-se os critérios que tenham ocasionado a exclusão e se realiza o movimento de recondução da autora ao lugar de reconhecimento e validação via revisionismo, resgate, divulgação e reedição de sua obra.
DICIONÁRIO DE LINGUÍSTICA DA ENUNCIAÇÃO
Authors: WITTKE Cleide Inês 
Published: March 2023

Bem estruturada e com conceitos bastante fundamentados, toda a obra Dicionário de Linguística da Enunciação (em suas 284 páginas), pelo modo como foi constituída, deixa transparecer o papel de um dicionário epistemológico (DUCROT e SCHAEFFER, 1995), ou seja, exerce a função de auxiliar o leitor a entender o texto específico da teoria que está analisando, aqui, no caso, das teorias da enunciação. Suas definições e especificações servem para orientar e auxiliar o estudioso, mas isso não o isenta de recorrer aos textos originais, caso tenha a intenção de conhecer e manusear as teorias enunciativas de modo mais preciso e aprofundado.
ANALISIS NILAI HASIL TERHADAP WAKTU PADA PROYEK RS HERMINA KUTABUMI TANGERANG
Authors: Purwanto Sugeng , Mu’min Muhammad Ali , Fernanda Alan 
Published: March 2023

Penelitian ini membahas mengenai biaya dan waktu dengan menggunakan Earned Value Analysis (EVA) pada proyek pembangunan RS Hermina Kutabumi Tangerang. Proyek RS Hermina Kutabumi Tangerang ini memiliki waktu rencana sekitar 40 minggu (285 hari) dengan rencana anggaran biaya sebesar ± Rp.60.000.000.000,00, dengan adanya batasan waktu dan biaya maka diperlukan pengendalian yang baik dan matang, akan tetapi sebelum dikakukan pengendalian perlu diketahui terlebih dahulu mengenai kinerja proyek yang telah berlangsung. Adapun tujuan dari penelitian ini adalah untuk mengetahui kinerja biaya dan waktu serta estimasi biaya dan waktu pada akhir penyelesaian proyek RS Hermina Kutabumi Tangerang. Metode Earned Value mamadukan unsur biaya dan waktu yang terjadi saat proyek berlangsung. Data yang didapatkan dari proyek antara lain time schedule, Rencana Anggaran Biaya (RAB), laporan bulanan dan biaya aktual, yang kemudian dilakukan analisis biaya, waktu, variasi serta indeks performansi dengan mamaparkan masalah yang muncul pada saat penelitian. Dari hasil analisa diketahui bahwa prakiraan waktu penyelesaian proyek apabila menggunakan perhitungan komulatif, berdasarkan minggu ke-39 adalah 292,01 hari (18 Oktober 2020), sedangkan waktu rencana adalah 285 hari (11 Oktober 2020). Hal ini menunjukkan bahwa waktu penyelesaian lebih lambat 7 hari dari yang direncanakan. Sedangkan apabila kita menggunakan perhitungan tiap minggu, Prakiraan waktu penyelesaian proyek berdasar minggu ke-39 adalah 291,80 hari (18 Oktober 2020), sehingga proyek mengalami keterlambatan 7 hari.Kata kunci: EVA, SPI, ETS, EAS, Perkiraan Waktu, Kurva S
ANALYSIS AND DESIGN OF ERP INFORMATION SYSTEMS USING WAREHOUSE MANAGEMENT MODULES
Authors: Destriana Rachmat 
Published: March 2023

Perusahaan PT XYZ bekerja di industri elektronik. Penyimpanan komoditas di gudang meningkat seiring dengan output. Oleh karena itu, ada masalah di PT. Gudang Inti Sarana Maju, yaitu tidak adanya integrasi data antar divisi sehingga tidak terjadi sharing data secara real time dan menyebabkan pencatatan jumlah barang secara manual menjadi salah. Akibatnya, terjadi ketidaksesuaian antara jumlah barang yang tertera di Stock Card dengan jumlah barang yang ada di gudang. Operasional Sub Divisi Gudang di PT.Inti Sarana Maju harus didukung oleh sistem informasi yang harus dikembangkan dan direncanakan. Sistem ini dirancang dan direncanakan dengan menggunakan metodologi RAD (Rapid Application Development). Penulis mengkaji prosedur bisnis operasional perusahaan. Berdasarkan penelitian ini, penulis membangun sistem ERP dengan aplikasi Odoo dan merancang proses bisnis yang diusulkan, dengan fokus pada modul Manajemen Gudang yang paling sesuai dengan kebutuhan organisasi. Selain itu, Pengguna akan menguji sistem yang dirancang sebelum menerapkannya pada bisnis. Hasil dari penelitian ini adalah modul Manajemen Gudang pada aplikasi Oodo yang telah disesuaikan dengan keadaan dan kebutuhan bisnis serta dapat membantu bisnis lebih mudah menyelesaikan masalah operasional gudang di PT. XYZ. Kata Kunci : ERP, Warehouse Management, Odoo, RAD
Harmonizing Duties of Board Members in the Anthropocene: When Expectations Meet Reality
Authors: Weber Anne-Marie , Mittwoch Anne-Christin 
Published: March 2023

The article confronts the European Commission’s climate policy-seconded endeavors regarding board members’ duties which it has expressed in its proposal for a Corporate Sustainability Due Diligence Directive (CSDDD Proposal) published in February 2022 with a comparative analysis of the current legal state of play in Germany and Poland. We claim that the Commission has neglected to adequately address the current understanding of board members’ duties across the Member States, which has ultimately led to the deletion of the Proposals’ provisions’ referring to the board members’ duty of care in the legislative work conducted within the Council of the European Union in November 2022. There is a possibility that these provisions (Art. 25 and 26 CSDDD Proposal) will be reinserted during the trialogue, but this is unlikely at this point. Notably, the Commission’s declaration on a mere clarifying role of the proposed harmonization measure regarding board members’ duties seems imprecise and prompts a weak interpretation of the proposed provisions, which contradicts the proclaimed policy goals. Germany might serve as an example of a Member State in which implementing the Commission’s understanding of the board members’ duty of care would not have significantly modified national company law, regardless of the interpretation chosen for the depth of the provision. If, however, a strong or medium mode of interpretation was applicable, Poland would actually be obliged to amend its legal framework fundamentally. Therefore, we contend that the legislative work on the discussed proposal was tainted by the flawed presumption that the proposed harmonization measure would merely summarize existing rules for board members’ duties. Based on the observations from our emblematic comparative juxtaposition, we argue that the idiosyncratic concepts of board members’ duties across Member States have not been sufficiently recognized as a harmonization challenge by the Commission. We contend that these methodological deficiencies led to an inconclusive wording of Article 25 of the Commission’s proposal and ultimately created an insurmountable barrier to political agreement within the Council and the “fall” of the complete concept of setting a standard of due care for board members in the proposed directive. Consequently, we claim that when jostling such a controversial and deep harmonization measure, the Commission must play its legislative A-game to have a shot at approval by the Council and later effective implementation by the Member States.
Gloss to the Decision of the European Court of Human Rights of May 15, 2018, Case Number 2451/16 , Association of Academics v. Iceland, Hudoc.int
Authors: Sołtys Karol 
Published: March 2023

In the judgment of the ECtHR in the case of Association of Academics v. Iceland, the Court commented on two important issues concerning the broadly understood procedure for resolving collective disputes. Firstly, the Court pointed out that “found that the taking of industrial action should be accorded the status of an essential element of the Article 11 guarantee but it is clear that strike action is protected by Article 11 as it is considered to be a part of trade union activity”. Secondly, it considered that the institution of mandatory arbitration could be a substitute for the right to strike, which was prohibited due to the need to protect the health of Icelandic citizens. In the context of the issues outlined in this way, the aim of the gloss is to verify the two theses mentioned above. First, the thesis was analyzed according to which the right to strike is not an essential element of freedom of association. For this reason, the jurisprudence of the Tribunal has been discussed against the background of ILO standards, taking into account the doctrine’s views on the status of the right to strike in the system of human rights protection and its relationship with other irenic methods of dispute resolution. Secondly, the thesis of the ECtHR was verified, according to which the mandatory arbitration established by the Icelandic legislator in the circumstances presented in the facts of the case does not constitute a violation of the right to strike. As part of the second thesis, the concept of mandatory arbitration and its status in the jurisprudence of the Court, as well as ILO bodies and labor law doctrine were analyzed. Finally, the relationship between the right to strike and social arbitration was examined.
Obligations of Entrepreneurs Providing Services by Electronic Means
Authors: Ganczar Małgorzata 
Published: March 2023

The development of new information and communication technologies affects economic development. E-services, along with the accompanying social changes, are being implemented in almost every area of human life, and the development of information and communication technologies makes it possible to employ a number of new instruments in its various spheres (e-banking, e-commerce, e-education, etc.). Currently, the information space in the context of the provision and use of e-services includes consumers and entrepreneurs although it assigns them different rights and obligations in this area. It seems necessary to assess the impact of the implementation by entrepreneurs of obligations related to the provision of e-services and their impact on the economy and on consumer safety in online trade. Legal changes concerning the obligations imposed on entrepreneurs in that field appear periodically in response to new threats related to dynamic technological development.The publication is devoted to an analysis of the provision of on-line services and an assessment of the law, in particular with regard to fulfilling information obligations with respect to consumers in cyberspace.
MITIGASI RISIKO MELALUI PENDEKATAN MULTIKULTURALISME JALAN KELUAR DALAM MEMPERKUAT KETAHANAN NASIONAL
Authors: Mohamad Tulus  
Published: March 2023

Pendekatan multikulturalisme merupakan pendekatan yang harus dikembangkan di dalam masyarakat yang merupakan paradigma pendekatan yang mampu memitigasi risiko penurunan ketahanan dengan transformasi kesadaran akan perbedaan, disampang itu pendekatan multikulturalisme dapat menjadi mitigasi risiko penurunan ketahanan nasional melalui transformasi pengetahuan tentang perbedaan sehingga dapat menjadi jalan keluar dalam meningkatkan ketahanan nasional. Alternatif ini menawarkan pendekatan berwawasan perbedaan dalam persatuan yang menyatukan. Paradigma mitigasi risiko berwawasan multikulturalisme tersebut bermuara pada terciptanya sikap masyarakat yang mau menghargai, menghormati perbedaan etnis, agama dan budaya dalam masyarakat. Untuk itu tujuan dari penelitian ini diarahkan untuk dalam rangka mitigasi peoblem ketahanan nasional saat ini, serta urugensi pendekatan multikultural terhadap ketahanan nasional. Hasil kajian menunjukan mitigasi risiko melalui pendekatan multikulturalisme harus difahami sebagai strategi pendekatan dalam mengatasi problem penurunan ketahanan nasional Indonesia saat ini.
Mitigasi risiko ketahanan nasional Indonesia yang merupakan kekuatan inti bagi eksistensi Negara Kesatuan Republik Indonesia tergantung dari kemampuan nilai-nilai kearifan lokal (local wisdom) untuk menghadapi arus perubahan nilai-nilai global.
Kata Kunci :Mitigasi Risiko, Pendekatan Multikultural, Ketahanan Nasonal
Hormonal predictors of circulatory diseases in liquidators of Chernobyl accident consequences
Authors: Drygina L. B. 
Published: March 2023

Relevance. Diseases of the circulatory system occupy a leading place in the structure of somatic pathology of liquidators. Obesity, signs of asthenization, vegetal vascular disorders, which were detected in numerous studies, suggest the presence of hypogonadism in this category of victims. Sex hormone deficiency is considered an important link in the formation of non-communicable diseases, which determined the relevance of the study.The goal. To carry out a retrospective assessment of the change in the hormonal indicators of the endocrine axis of hypophysis-sex hormones and to assess the effect of partial androgen deficiency on the formation of circulatory diseases in the dynamics of the examination in the liquidators of the consequences of the Chernobyl accident.Materials and methods. Hormonal indicators of the pituitary-gonadal endocrine axis were investigated by immunochemical analysis in 1065 men involved in the aftermath of the Chernobyl accident in 1986–1987, combined into groups depending on the period of examination from 1994 to 2019 and in control groups. The average age of patients entering the Chernobyl zone was 33.6 (0.8) years.Results. Seven years after the accident, liquidators in 13.1 % cases show a shortage of sex hormones, by 33 years of follow-up, the proportion of such patients increases by 4.6 times. Sex hormone deficiency 7 years after the accident was revealed in men of relatively young age, the correlation of testosterone levels with the concentration of gonadotropins and prolactin has not been established. The increase in prolactin in the liquidators of the consequences of the Chernobyl accident, reliable in relation to the control group, remains for 12 years after the accident. 30–33 years after the accident, participants in the elimination of the consequences of the Chernobyl accident have significant age-related changes in hormonal indicators, among which the main is partial androgen deficiency.Conclusions. The persistent imbalance of hormones of the pituitary-gonadal endocrine axis at the time of 1994–1998 contributed to the clinical manifestation of circulatory diseases in liquidators – middle-aged men, clinical symptoms, on the other hand, aggravated diverse shifts in the functioning of this endocrine axis of regulation. In the later period of observation by 30–33 years after the accident, a decrease in androgen levels was accompanied by a steady increase in circulatory diseases in liquidators.
Infectious viruses from transfected SARS-CoV-2 genomic RNA
Authors: Väisänen Elina , Jiang Miao , Laine Larissa , Waris Matti , Julkunen Ilkka , Österlund Pamela 
Published: March 2023

SARS-CoV-2 emerged at the end of 2019, and like other novel pathogens causing severe symptoms, WHO recommended heightened biosafety measures for laboratories working with the virus. The positive-stranded genomic RNA of coronaviruses has been known to be infectious since the 1970s, and overall, all experiments with the possibility of SARS-CoV-2 propagation are carried out in higher containment level laboratories. However, as SARS-CoV-2 RNA has been routinely handled in BSL-2 laboratories, the question of the true nature of RNA infectiousness has risen along with discussion of appropriate biosafety measures. Here, we studied the ability of native SARS-CoV-2 genomic RNA to produce infectious viruses when transfected into permissive cells and discussed the biosafety control measures related to these assays. In transfection assays large quantities of genomic vRNA of SARS-CoV-2 was required for a successful production of infectious viruses. However, the quantity of vRNA alone was not the only factor, and especially when the transfected RNA was derived from infected cells, even small amounts of genomic vRNA was enough for an infection. Virus replication was found to start rapidly after transfection, and infectious viruses were detected in the cell culture media at 24 h post-transfection. In addition, silica membrane-based kits were shown to be as good as traditional TRI-reagent based methods in extracting high-quality, 30 kb-long genomic vRNA. Taken together, our data indicates that all transfection experiments with samples containing genomic SARS-CoV-2 RNA should be categorized as a propagative work and the work should be conducted only in a higher containment BSL-3 laboratory.
Analysis of cerebral infarction caused by dysplasminogenemia in three pedigrees
Authors: Chen Xuanyu , Zou Ming , Lu Chunxing , Zhou Ruyi , Lou Shuyue , Wang Yujia , Ding Hongxiang , Han Zhao , Hu Beilei 
Published: March 2023

Background and aims: Dysplasminogenemia is a rare heritable disease caused by plasminogen (PLG) gene defects resulting in hypercoagulability. In this report we describe three notable cases of cerebral infarction (CI) complicated with dysplasminogenemia in young patients.Methods: Coagulation indices were examined on STAGO STA-R-MAX analyzer. PLG: A was analyzed using a chromogenic substrate-based approach using a chromogenic substrate method. All nineteen exons of PLG gene and their 5′and 3′flanking regions were amplified by Polymerase chain reaction (PCR). Suspected mutation was confirmed by reverse sequencing.Results: PLG activity (PLG:A) in proband 1 and 3 of his tested family members, proband 2 and 2 of his tested family members, and proband 3 and her father were all reduced to roughly 50% of normal levels. Sequencing led to the identification of a heterozygous c.1858G&gt;A missense mutation in exon 15 of the PLG gene in these three patients and affected family members.Conclusion: We conclude that the observed reduction in PLG:A was the result of this p.Ala620Thr missense mutation in the PLG gene. The CI incidence in these probands may be attributable to the inhibition of normal fibrinolytic activity as a consequence of this heterozygous mutation.
Qualitative analysis of anti-abortion discourse used in arguments for a 6-week abortion ban in South Carolina
Authors: Lambert Victoria C. , Hackworth Emily E. , Billings Deborah L. 
Published: March 2023

BackgroundOn June 24, 2022, The U.S. Supreme Court overturned Roe v. Wade, leaving abortion legislation entirely up to states. However, anti-abortion activists and legislators have organized for decades to prevent abortion access through restrictive state-level legislation. In 2019, South Carolina legislators proposed a bill criminalizing abortion after 6 weeks gestation, before most people know they are pregnant. The current study examines the anti-abortion rhetoric used in legislative hearings for this extreme abortion restriction in South Carolina. By examining the arguments used by anti-abortion proponents, we aim to expose their misalignment with public opinion on abortion and demonstrate that their main arguments are not supported by and often are counter to medical and scientific evidence.MethodsWe qualitatively analyzed anti-abortion discourse used during legislative hearings of SC House Bill 3020, The South Carolina Fetal Heartbeat Protection from Abortion Act. Data came from publicly available videos of legislative hearings between March and November 2019, during which members of the public and legislators testified for and against the abortion ban. After the videos were transcribed, we thematically analyzed the testimonies using a priori and emergent coding.ResultsTestifiers (Anti-abortion proponents) defended the ban using scientific disinformation and by citing advances in science to redefine “life.” A central argument was that a fetal “heartbeat” (i.e., cardiac activity) detected at 6 weeks gestation indicates life. Anti-abortion proponents used this to support their argument that the 6-week ban would “save lives.” Other core strategies compared anti-abortion advocacy to civil rights legislation, vilified supporters and providers of abortion, and framed people who get abortions as victims. Personhood language was used across strategies and was particularly prominent in pseudo-scientific arguments.DiscussionAbortion restrictions are detrimental to the health and wellbeing of people with the potential to become pregnant and to those who are pregnant. Efforts to defeat abortion bans must be grounded in a critical and deep understanding of anti-abortion strategies and tactics. Our results reveal that anti-abortion discourse is extremely inaccurate and harmful. These findings can be useful in developing effective approaches to countering anti-abortion rhetoric.