bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the Effect of Exercises With Different Gluteal-to-Tensor Fasciae Latae Activation Index in Patients With Chronic Low Back Pain
Authors: Jahandideh Leila , Letafatkar Amir , Khanzadeh Reza , Omidi Kashani Farzad 
Published: July 2023

Context: Hip muscle imbalance, especially between gluteal muscles and tensor fasciae latae (TFL), is one of the risk factors for developing low back pain which should be considered in rehabilitation programs. This study compared the effect of exercises with gluteal-to-TFL muscle activation index above and below 50 on pain intensity, disability, and lower limbs’ range of motion (ROM) in patients with nonspecific chronic low back pain. Design: A semiexperimental intervention study with a pretest and posttest. Methods: A total of 45 patients with nonspecific chronic low back pain were randomly divided into 2 experimental groups of gluteal-to-TFL muscle activation index above 50 (n = 15), below 50 (n = 15), and a control group (n = 15). Pain intensity (visual analog scale), disability (Roland–Morris Disability Questionnaire), and lower limbs’ ROM including hip extension, hip abduction, hip external rotation, and knee extension (goniometer) were assessed at pretest and after 8 weeks of intervention. Results: Within-group comparison showed significant improvement of pain, disability, and ROMs in both experimental groups. No significant changes were observed in the control group. In between-group analysis, significant differences were observed in group of gluteal-to-TFL muscle activation index above 50 for only pain (P = .03) and disability (P = .01). For ROMs, although clinical improvement of lower limbs’ ROMs was higher in group of gluteal-to-TFL muscle activation index above 50, no statistically significant differences were found between 2 experimental groups. Both experimental groups were superior to the control group for all outcomes. Conclusions: Findings indicate the statistically and clinically superior effectiveness of exercises with a gluteal-to-TFL muscle activation index above 50 in the reduction of pain and disability. Based on the clinical significance of exercises with a gluteal-to-TFL muscle activation index above 50 for improving ROMs, utilizing specific exercises that more activated gluteal muscle compared to TFL is recommended for patient with restricted lower limbs’ ROMs.
Ubiquitination of acetyltransferase Gcn5 contributes to fungal virulence in
Fusarium graminearum
Authors: Chen Ahai , Zhou Yifan , Ren Yiyi , Liu Chao , Han Xingmin , Wang Jing , Ma Zhonghua , Chen Yun 
Published: July 2023

ABSTRACT

The histone acetyltransferase general control non-depressible 5 (Gcn5) plays a critical role in the epigenetic landscape and chromatin modification for regulating a wide variety of biological events. However, the post-translational regulation of Gcn5 itself is poorly understood. Here, we found that Gcn5 was ubiquitinated and deubiquitinated by E3 ligase Tom1 and deubiquitinating enzyme Ubp14, respectively, in the important plant pathogenic fungus
Fusarium graminearum
. Tom1 interacted with Gcn5 in the nucleus and subsequently ubiquitinated Gcn5 mainly at K252 to accelerate protein degradation. Conversely, Ubp14 deubiquitinated Gcn5 and enhanced its stability. In the deletion mutant Δ
ubp14
, protein level of Gcn5 was significantly reduced and resulted in attenuated virulence in the fungus by affecting the mycotoxin production, autophagy process, and the penetration ability. Our findings indicate that Tom1 and Ubp14 show antagonistic functions in the control of the protein stability of Gcn5 via post-translational modification and highlight the importance of Tom1-Gcn5-Ubp14 circuit in the fungal virulence.

IMPORTANCE

Post-translational modification (PTM) enzymes have been reported to be involved in regulating numerous cellular processes. However, the modification of these PTM enzymes themselves is largely unknown. In this study, we found that the E3 ligase Tom1 and deubiquitinating enzyme Ubp14 contributed to the regulation of ubiquitination and deubiquitination of acetyltransferase Gcn5, respectively, in
Fusarium graminearum
, the causal agent of Fusarium head blight of cereals. Our findings provide deep insights into the modification of acetyltransferase Gcn5 and its dynamic regulation via ubiquitination and deubiquitination. To our knowledge, this work is the most comprehensive analysis of a regulatory network of ubiquitination that impinges on acetyltransferase in filamentous pathogens. Moreover, our findings are important because we present the novel roles of the Tom1-Gcn5-Ubp14 circuit in fungal virulence, providing novel possibilities and targets to control fungal diseases.
Effect of Magnetic Field and Inclined Load on a Two-Dimensional Thermoelastic Medium Under Gravity
Authors: De Amrita , Purkait Pallabi , Das Payel , Kanoria Mridula 
Published: July 2023

This work aims to investigate the effects of magnetic field and inclined load on a two-dimensional thermoelastic medium under gravitational field. The problem is formulated in the context of refined dual-phase-lag Green–Naghdi (DPL GN) model. The bounding plane surface is heated by a non-Gaussian laser beam. The inclined load is supposed to be a linear combination of a normal load and a tangential load. Analytical formulas for several physical quantities are generated on the transformed domain using the Laplace and Fourier transform techniques. The inversion of double transform has been done numerically by using MATHEMTICA 10. The numerical inversion of Laplace transform is done by using the Zakian method (Halsted and Brown [Zakians technique for inverting Laplace transforms, J. Chem. Eng. 3 (1972) 312–313]). All physical quantities have been graphically depicted for the dual-phase-lag Green–Naghdi type III model (DPL GN-III), simple Green–Naghdi type III model (simple GN-III), Lord–Shulman model (LS) and classical thermoelasticity theory (CTE) to indicate the effect of magnetic field and the angle of inclination of the medium.
Topographical Analysis of Pacinian Corpuscle in the Pulp of Human Cadaver Finger Tip Pulp: A Pilot Cadaver Study
Authors: LEE Hyun-Joo , DESLIVIA Maria Florencia , KHOLINNE Erica , RHYU Im Joo , LEE Suk-Joong , JEON In-Ho 
Published: July 2023

Background: The human hand is a specialised organ for fine motion and sensation and has a relatively large representation in the homunculus. The pathway of sensation starts from information sent by mechanoreceptors in the hand. This study reports the topography of the Pacinian corpuscle in the fingertips of a human cadaver. Methods: All 10 digits from both hands of a fresh-frozen cadaver were examined. Glabrous skin distal to the distal interphalangeal joint was harvested superficial to the periosteum including fat and subcutaneous tissue. The glabrous skin were divided into 10 sections that included five distal and five proximal sections. Modified gold chloride staining was performed. Sectioned specimens were observed under a light microscope and the density of Pacinian corpuscles was determined in each segment. The density of the corpuscles was compared between the radial/ulnar and proximal/distal segments and also between digits from the right hand versus those from the left hand. Results: Pacinian corpuscles were observed only in the subcutaneous tissue. There was no significant difference in density of the corpuscles between the distal and proximal segments or between the right and left hands. There was a statistically significant greater density of Pacinian corpuscles on the radial segments of all digits except the thumb. Conclusions: There is a greater density of Pacinian corpuscles on the radial side of the human fingertip in all digits except the thumb.
Opponensplasty for Severe Carpal Tunnel Syndrome with the Transfer of the Palmaris Longus Tendon to the Rerouted Extensor Pollicis Brevis Tendon
Authors: KIMORI Kenji , HACHISUKA Hiroki 
Published: July 2023

The authors describe a novel opponensplasty for severe carpal tunnel syndrome that uses the palmaris longus (PL) tendon transferred to the rerouted extensor pollicis brevis (EPB) tendon with pulley reconstruction using a portion of the PL tendon simultaneously with the carpal tunnel release. Like the Camitz opponensplasty, this technique utilises the PL as the motor source, does not require special postoperative treatment and enables fast functional recovery even in older patients. Compared with the Camitz procedure, this technique can easily acquire thumb rotation without tendon bowstringing. Furthermore, because the function of the EPB tendon is preserved, the tendency of flexion in the thumb metacarpophalangeal (MP) joint is not observed after surgery, and improvement can be expected in patients with preoperative MP joint extension lag. This technique is a useful alternative to the Camitz procedure, as it overcomes the disadvantages of the Camitz procedure while preserving the advantages. Level of Evidence: Level V (Therapeutic)
Pregnancy Outcomes in Secondary Infertility for Women with versus without Cesarean Scar Defect
Authors: Tran Van T. T. , Ho Vu N. A. , Pham Toan D. , Nguyen Nam T. , Hoang Hieu L. T. , Nguyen Duy L. , Ho Tuong M. , Vuong Lan N. 
Published: July 2023

Background: This study investigated pregnancy outcomes after expectant management and infertility treatment in women with secondary infertility, with and without cesarean scar defect (CSD). Methods: This retrospective cohort study was conducted at IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam. Women aged [Formula: see text]18 years with at least one previous cesarean section were eligible. Women who had any uterine malformation, leiomyoma, adenomyosis, and myometrial surgery (except for cesarean section or previous CSD repair) were excluded. Patients were followed up for 15 months. The primary outcome was the cumulative live birth rate. Results: A total of 340 women were included between October 2020 and March 2021. The cumulative live birth rate did not differ significantly between women with and without CSD (odds ratio 0.76; 95% confidence interval 0.47–1.22; [Formula: see text] = 0.256). In patients with CSD, only 6/117 (5%) had obstetrics complications, such as placenta previa and postpartum hemorrhage. Conclusions: These data indicate that CSD does not appear to have a significant detrimental effect on pregnancy outcomes in our cohort of patients. This information is useful to help physicians to counsel women with secondary infertility and CSD.
Synthesis, Characterization, Density Functional Theory, Monte Carlo, and Molecular Dynamics Simulations of [Ni(Ii)(Tpy)2] Metal Organic Framework and Congo Red Dye Application
Authors: Olawale Margaret D. , Akintemi Eric O. , Ojo Nathanael D. , Isaac Aaron Y. , Su Hong , Obaleye Joshua A. 
Published: July 2023

Effluents from dyeing companies are a major polluter of the environment and water bodies. An estimated 70 tons of dye are generated globally each year, with more than one-third of this amount lost to the environment. To combat this issue, novel chemical compounds that are more efficient than existing ones are proposed. The soft synthetic approach was used to create [Ni(II)(Tpy)2] MOF by reacting nickel nitrate with terpyridine (Tpy). The melting point of the MOF was determined, as well as the EA, HSM, TGA, PXRD, and X-ray crystallographic studies. The MOF results support the synthesis and coordination of the nickel (II) ion with the two Tpy molecules. In application, [Ni(II)(Tpy)2] MOF was utilized to study the adsorption of Congo red. After 30 min of adsorption time, 1 g of [Ni(II)(Tpy)2] MOF adsorbed a high amount of Congo red (138.26 mg) at [Formula: see text]C and a pH of 2. When compared to other isotherms, the Langmuir isotherm provided the best fit. Adsorption kinetics demonstrating electrostatic interaction between MOF and Congo red might be interpreted using the pseudo-second-order model. Density functional theory, Monte Carlo, and molecular dynamics simulations of the [Ni(II)(Tpy)2] MOF over Congo red dye were computed. Density functional theory calculations provide insights into the reactivity of the novel [Ni(II)(Tpy)2] MOF by furnishing chemical reactivity parameters that explain the interactions and adsorption processes between the [Ni(II)(Tpy)2] MOF and Congo red. The quantum mechanical calculations provide data for an insightful understanding of the reactivity of the MOF and its high adsorption on the Congo red surface. Low band gaps (1.40 and 1.43 eV in the gas phase and water, respectively) obtained for the [Ni(II)(Tpy)2] MOF suggest that this will make an extrinsic semiconductor with high electrical conductivity. Thus, it would readily interact with and be adsorbed on the Congo red.
A Dynamic Attributes-driven Graph Attention Network Modeling on Behavioral Finance for Stock Prediction
Authors: Zhang Qiuyue , Zhang Yunfeng , Yao Xunxiang , Li Shilong , Zhang Caiming , Liu Peide 
Published: July 2023

Stock prediction is a challenging task due to multiple influencing factors and complex market dependencies. Traditional solutions are based on a single type of information. With the success of multi-source information in different fields, the combination of different types of information such as numerical and textual information has become a promising option.
Although multi-source information provides rich multi-view information, how to mine and construct structured relationships from them is a difficult problem. Specifically, most existing methods usually extract features from commonly used multi-source information as predictive information sources, without further pre-constructing stock relationship graphs with dependencies using broader information. More importantly, they typically treat each stock as an isolated forecasting, or employ stock market correlations based on a fixed predefined graph structure, but current methods are not sensitive enough to aggregate the attribute features extracted from multi-source information and stock relationship graph, to obtain the dynamic update of market relations and relationship strength. The stock market is highly temporally, and the attributes of nodes are affected by the time perception of other attributes, which is not fully considered.
To address these problems, we propose a novel dynamic attributes-driven graph attention networks incorporating sentiment (DGATS) information, transaction data, and text data. Inspired by behavioral finance, we separately extract sentiment information as a factor of technical indicators, and further realize the early fusion of technical indicators and textual data through Kronecker product-based tensor fusion. In particular, by LSTM and temporal attention network, the short-term and long-term transition features are gradually grasped from the local composition of the fused stock trading sequence. Furthermore, real-time intra-market dependencies and key attributes information are captured with graph networks, enabling dynamic updates of relationships and relationship strengths in predefined graphs. Experiments on the real datasets show that the architecture can outperform the previous methods in prediction performance.
Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy
Authors: Liu Yifan , Wang Hongying , Zhao Xinyu , Zhang Jiashen , Zhao Zhiling , Lian Xia , Zhang Juan , Kong Feng , Hu Tao , Wang Ting , Li Xiaohua , Wang Lei , Wang Dapeng , Li Chunling , Luan Huiwen , Liu Xiaoli , Wang Chunyan , Jiang Yun , Li Xiaomin , Li Fangmin , Ji Shuhao , Wang Yaopeng , Li Zunling 
Published: July 2023

Abstract

Immune checkpoints modulate the immune response and represent important immunotherapy targets for cancer treatment. However, as many tumors are resistant to current immune checkpoint inhibitors, the discovery of novel immune checkpoints could facilitate the development of additional immunotherapeutic strategies to improve patient responses. Here, we identified increased expression of the adhesion molecule immunoglobulin superfamily member 9 (IGSF9) in tumor cells and tumor-infiltrating immune cells across multiple cancer types. IGSF9 overexpression or knockout in tumor cells did not alter cell proliferation in vitro or tumor growth in immunocompromised mice. Alternatively, IGSF9 deficient tumor cells lost the ability to suppress T-cell proliferation and exhibited reduced growth in immunocompetent mice. Similarly, growth of tumor cells was reduced in IGSF9 knockout syngeneic and humanized mice, accompanied by increased tumor-infiltrating T cells. Mechanistically, the extracellular domain (ECD) of IGSF9 bound to T cells and inhibited their proliferation and activation, and the tumor-promoting effect of IGSF9 ECD was reversed by CD3+ T-cell depletion. Anti-IGSF9 antibody treatment inhibited tumor growth and enhanced the antitumor efficacy of anti-programmed cell death protein 1 immunotherapy. Single-cell RNA sequencing revealed tumor microenvironment remodeling from tumor promoting to tumor suppressive following anti-IGSF9 treatment. Together, these results indicate that IGSF9 promotes tumor immune evasion and is a candidate immune checkpoint target.

Significance:
IGSF9 is an immune checkpoint regulator that suppresses T-cell activation in cancer and can be targeted to stimulate antitumor immunity and inhibit tumor growth.
The Critical Interplay of CAF Plasticity and Resistance in Prostate Cancer
Authors: Li Xiaoling , Mu Ping 
Published: July 2023

Abstract
Prostate cancer is a common malignancy driven by the androgen receptor (AR) pathway, with androgen deprivation therapy (ADT) being a standard treatment. However, the development of castration-resistant prostate cancer (CRPC) poses a significant challenge. CRPC is characterized by significantly increased tumor heterogeneity and lineage plasticity. Current research has primarily emphasized intrinsic tumor mechanisms, paying less attention to the role of the tumor microenvironment in cancer recurrence and drug resistance. In their recent study published in Cancer Cell, Wang and colleagues used single-cell RNA sequencing in genetically engineered mouse models with prostate tumors at different stages. They revealed that SPP1+ myofibroblastic cancer-associated fibroblasts (myCAF), induced by ADT, play an instrumental role in CRPC development. Their work also underscores the association between therapy-induced phenotypic alterations of CAFs and disease progression. This discovery highlights the potential for stromal compartment targeting as a means to mitigate CRPC development and overcome treatment resistance.
A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
Authors: Van Loon Katherine , Mmbaga Elia J. , Mushi Beatrice P. , Selekwa Msiba , Mwanga Ally , Akoko Larry O. , Mwaiselage Julius , Mosha Innocent , Ng Dianna L. , Wu Wei , Silverstein Jordyn , Mulima Gift , Kaimila Bongani , Gopal Satish , Snell Jeff M. , Benz Stephen Charles , Vaske Charles , Sanborn Zack , Sedgewick Andrew J. , Radenbaugh Amie , Newton Yulia , Collisson Eric A. 
Published: July 2023

Abstract

Background:
Esophageal squamous cell carcinoma (ESCC) comprises 90% of all esophageal cancer cases globally and is the most common histology in low-resource settings. Eastern Africa has a disproportionately high incidence of ESCC.

Methods:
We describe the genomic profiles of 61 ESCC cases from Tanzania and compare them to profiles from an existing cohort of ESCC cases from Malawi. We also provide a comparison to ESCC tumors in The Cancer Genome Atlas (TCGA).

Results:
We observed substantial transcriptional overlap with other squamous histologies via comparison with TCGA PanCan dataset. DNA analysis revealed known mutational patterns, both genome-wide as well as in genes known to be commonly mutated in ESCC. TP53 mutations were the most common somatic mutation in tumors from both Tanzania and Malawi but were detected at lower frequencies than previously reported in ESCC cases from other settings. In a combined analysis, two unique transcriptional clusters were identified: a proliferative/epithelial cluster and an invasive/migrative/mesenchymal cluster. Mutational signature analysis of the Tanzanian cohort revealed common signatures associated with aging and cytidine deaminase activity (APOBEC) and an absence of signature 29, which was previously reported in the Malawi cohort.

Conclusions:
This study defines the molecular characteristics of ESCC in Tanzania, and enriches the Eastern African dataset, with findings of overall similarities but also some heterogeneity across two unique sites.

Impact:
Despite a high burden of ESCC in Eastern Africa, investigations into the genomics in this region are nascent. This represents the largest comprehensive genomic analysis ESCC from sub-Saharan Africa to date.
Changes in Geographic Variation and Socioeconomic Inequalities in Esophageal Cancer Mortality in China, 1973–2017
Authors: Ran Xianhui , Zheng Rongshou , Zeng Hongmei , Zhang Siwei , Sun Kexin , Han Bingfeng , Wang Shaoming , Chen Ru , Li Li , Wei Wenqiang , He Jie 
Published: July 2023

AbstractBackground:Geographic variability in esophageal cancer has been reported in China, but data are lacking at the local level. We aimed to investigate changes in disparities in esophageal cancer–related mortality among Chinese counties and whether county-level socioeconomic status was associated with this variation.Methods:We used data from a nationwide survey and population-based cancer registries to calculate esophageal cancer–related mortality rates for 782 Chinese counties for the periods of 1973–1975 and 2015–2017. We performed hotspot analysis to identify spatial clusters. We used a multivariable negative binomial regression model to estimate the associations between county-level socioeconomic factors and mortality.Results:From 1973–1975 to 2015–2017, the age-standardized esophageal cancer–related mortality rate decreased from 27 to 8 per 100,000 person-years in China. By county, 577 (74%) of 782 counties experienced decreasing mortality. Geographic disparities in mortality substantially narrowed, with the gap in mortality rates between 90th and 10th percentile counties decreasing from 55 per 100,000 person-years in 1973–1975 to 16 in 2015–2017. However, clusters of elevated rates persisted across north-central China. Rurality [adjusted mortality rate ratio (MRR) 1.15; 95% confidence interval (CI), 1.10–1.21], per capita gross domestic product (adjusted MRR, 0.95; 95% CI, 0.91–0.98), and percentage of people with a high-school diploma (adjusted MRR, 0.86; 95% CI, 0.84–0.87) in a county were significantly associated esophageal cancer–related mortality rates.Conclusions:China has made substantial progress in reducing esophageal cancer–related mortality and disparities, but the intercounty differences remain large.Impact:Continued efforts are needed to address the geographical and socioeconomic disparities in esophageal cancer.