bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uptake of modern contraceptive methods among women of reproductive age in Chake District-Pemba Tanzania: a descriptive crossectional study
Authors: Abeid Rehema Abdalla , Sumari Emmanuel Izack , Qin Chunxiang , Lyimo Ally Abdul , Luttaay Godrian Aron 
Published: July 2023

Abstract
Background
The uptake of the modern contraceptive method provides chances for women and couples to reach optimal child spacing, achieve the desired family size and prevent unsafe abortions and maternal deaths. Despite the efforts in the health sector still, the contraceptive prevalence rate in Zanzibar remains low (9.1%). In Pemba, few studies have been done on modern contraceptive uptake and little is known about factors that hinder the uptake of modern contraceptives among women of reproductive age. This study investigated the uptake of modern contraceptive methods among women of reproductive age (18-45 years) and its associated factors.

Methods
This was a quantitative cross-sectional study conducted in Chake District Hospital, Pemba Tanzania. A stratified random sampling technique was used to recruit 214 eligible participants for the study. After we informed the participants, data were collected using a structured English questionnaire. The collected data was analyzed using SPSS version 25, descriptive analysis was done to determine frequencies. A chi-square test was done to determine the association between the study variables and multivariate logistic regression to check the nature and strength of the association. The p<0.05 was considered statistically significant.

Results
This study included 214 women of with majority 79(36.9%) at the age group of 21-30 years, 100(46.7%) had secondary education and 187(87.4%) married. Most of the participants 212(99.1%) have heard about modern contraceptives, with health facilities being the common source of information191(45.3). More than half 120(56.1%) of the participants were not using any modern contraceptive method and injectable 38(40.4%) was the commonly reported method among users. Among the users of modern contraceptives, lack of power to decide 180(84.1%), fear of divorce 141(65.9%), and social perception of users as the cause of reduced workforce in the future 161(75.2%) were common barriers. Participants provided suggestions to improve modern contraceptive uptake including male involvement 203(94.9%) and community awareness 182(85%). Further analysis revealed women with college/university education were 2 times more likely to use modern contraceptives method compared to those with primary or not attended school(p=0.023, OR=2.437, 95% CI: 1.129-5.259). Moreover employed women were 2 times more likely to use modern contraceptives compared to unemployed/housewives (p=0.028, OR=1.844, CI=1.068-3.185).

Conclusion
This study assesses the uptake of modern contraceptives among women of reproductive age. Results showed a low uptake of modern contraceptives in this population.
Although the observation in this study is similar to those reported in other countries, the updated information is still important to the policymakers and the Ministry of Health in the studied district.
Lipid in microglial biology — from material to mediator
Authors: Yamamoto Shota , Masuda Takahiro 
Published: July 2023

AbstractMicroglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of microglial functionality. Lipids are highly diverse materials and crucial components of cell membranes in every cell. Accumulating evidence has shown that lipid and its metabolism are tightly involved in microglial biology. In this review, we summarize the current knowledge about microglial lipid metabolism in health and disease.
Students’ voices on generative AI: perceptions, benefits, and challenges in higher education
Authors: Chan Cecilia Ka Yuk , Hu Wenjie 
Published: July 2023

AbstractThis study explores university students’ perceptions of generative AI (GenAI) technologies, such as ChatGPT, in higher education, focusing on familiarity, their willingness to engage, potential benefits and challenges, and effective integration. A survey of 399 undergraduate and postgraduate students from various disciplines in Hong Kong revealed a generally positive attitude towards GenAI in teaching and learning. Students recognized the potential for personalized learning support, writing and brainstorming assistance, and research and analysis capabilities. However, concerns about accuracy, privacy, ethical issues, and the impact on personal development, career prospects, and societal values were also expressed. According to John Biggs’ 3P model, student perceptions significantly influence learning approaches and outcomes. By understanding students’ perceptions, educators and policymakers can tailor GenAI technologies to address needs and concerns while promoting effective learning outcomes. Insights from this study can inform policy development around the integration of GenAI technologies into higher education. By understanding students’ perceptions and addressing their concerns, policymakers can create well-informed guidelines and strategies for the responsible and effective implementation of GenAI tools, ultimately enhancing teaching and learning experiences in higher education.
Hierarchical under frequency load shedding scheme for inter-connected power systems
Authors: Cai Guowei , Zhou Shuyu , Liu Cheng , Zhang Yuchi , Guo Shujia , Cao Zhichong 
Published: July 2023

AbstractSevere disturbances in a power network can cause the system frequency to exceed the safe operating range. As the last defensive line for system emergency control, under frequency load shedding (UFLS) is an important method for preventing a wide range of frequency excursions. This paper proposes a hierarchical UFLS scheme of “centralized real-time decision-making and decentralized real-time control” for inter-connected systems. The centralized decision-layer of the scheme takes into account the importance of the load based on the equivalent transformation of kinetic energy (KE) and potential energy (PE) in the transient energy function (TEF), while the load PE is used to determine the load shedding amount (LSA) allocation in different loads after faults in real-time. At the same time, the influence of inertia loss is considered in the calculation of unbalanced power, and the decentralized control center is used to implement the one-stage UFLS process to compensate for the unbalanced power. Simulations are carried out on the modified New England 10-generator 39-bus system and 197-bus system in China to verify the performance of the proposed scheme. The results show that, compared with other LSA allocation indicators, the proposed allocation indicators can achieve better fnadir and td. At the same time, compared with other multi-stage UFLS schemes, the proposed scheme can obtain the maximum fnadir with a smaller LSA in scenarios with high renewable energy sources (RES) penetration.
Comparative study between the outcome of decompressive craniotomy versus craniectomy in the management of acute subdural hematoma
Authors: Azouz Heba Mohamed , Soffar Hussein Mohammed Hussein , Abbass Waleed Abdelaal , Ahmed Ahmed El-said , El-far Mohamed Tarek 
Published: July 2023

Abstract
Background
Acute Subdural hematoma is a very crucial entity in traumatic brain injury, presented with disabling morbid complications and a high mortality rate; therefore, it is a massive socio-economic burden, leading to either direct or secondary brain injury, as hypoxia.

Aim and objectives
Comparative study between decompressive craniotomy (DC) and craniectomy in the management of acute subdural and their consequences. Assessing the most effective management protocol for ASDH with the least morbidity, short hospital’ stay and avoidance of re-operation.

Method
The study design is a prospective comparative randomized study, conducted on 30 patients with ASDH operated and managed starting December 2019 inclusive April 2021 at the Neurosurgery Department Cairo University Hospitals. They were divided equally into two groups: 15 had decompressive craniectomy and another 15 cases were operated upon with craniotomy. All patients were diagnosed with traumatic ASDH.

Results
The mean GCS pre-operative in DC was (9.4) mean with a range from (6 to 13) and the post-operative mean was (11.13) with a range from (4 to 15) compared to the results in the craniotomy group; the pre-operative mean was (9.6) with a range from (6 to 10) and the post-operative GCS mean (11.53) ranging from (6 to 14) that had a P value of 0.69.

Conclusion
There is no statistical significance in comparing decompressive craniectomy and craniotomy in dealing with ASDH, yet early time of surgical evacuation and duroplasty have shown to have good prognostic factors.
Sequence analysis of TLR4 gene in river buffalo (Egyptian breed) and SNPs association with Mastitis
Authors: Abou Mossallam Ahlam , El Nahas Soheir M. , Osman Noha M. , Shahwan El-Hassan T. , Sabry Nevien M. 
Published: July 2023

AbstractBackgroundMastitis is a major cause of economic loss for dairy farmers and industry. River buffalo plays an economically significant role in Egypt. Buffaloes with mastitis have reduced milk yield and change in milk composition. Genetic variations in the Toll-like receptor4 (TLR4) gene have been related to several diseases in farm animals and humans including mastitis. The present investigation aims to find the genotypic variations in the TLR4 gene and their relation to mastitis in the river buffalo, Egyptian breed.ResultsDNA from 30 buffaloes' blood samples (15 healthy and 15 with mastitis) were extracted and the TLR4 gene was sequenced. Twenty-one Single nucleotide polymorphisms (SNPs) were found from which four SNPs were associated with mastitis: one in 5'UTR (c.1-g27) and 3 SNPs in the coding region at c.87, c.575, and c.576. The nucleotide variations in SNPs c.1-g27(C > A) and c.87 (C > A) were only present in buffalo with mastitis, while buffaloes with genotype CC at both locations were healthy. The AA genotype at c.87 (P.29) results in a stop codon leading to an abnormally shortened protein. The nonsynonymous SNPs c.575 A > G and c.576 T > G shared amino acid 192 resulting in three amino acids (His192Arg/Gln). The dominant genotypes AA at c.575 and TT at c.576 were associated with mastitis resistance (OR < 1.00), while recessive genotype GG at c.575 was associated with mastitis susceptibility (OR > 1.00). These two SNPs may affect their role in ligand recognition since they were in the LRR4 domain (p.174–p.197) which is part of coreceptor binding region 1.ConclusionsThe present study confirms the relation between TLR4 genotypes and mastitis resistance or mastitis susceptibility in Egyptian dairy buffalo. The study suggested four SNPs (c1-g27C > A, c.87 C > A, c.575A > G, and c.576 T > G) have the potential to be markers for assisted buffalo selection to improve milk production.
Cardioprotective effect of propofol in cardioplegia compared to systemic propofol in heart valves surgery; a randomized controlled trial
Authors: Attia Amr Atef , Torky Mohammad Abd Elmoneim , Abo Elnasr Mohamed Mahmoud , Wahby Ehab Abd Elmonem , Taha Abd Elhady Mohammed 
Published: July 2023

AbstractBackgroundMyocardial protection is still a focus of ongoing research. Propofol is used widely during the induction of anaesthesia in cardiac surgery. So, this triggers us to investigate the cardioprotective effect of the propofol when added to the cardioplegia compared to systemic propofol by measuring the troponin T level.MethodsThis clinical randomized controlled trial was carried out on 150 patients operated for elective valvular heart surgery. Patients were assigned into three equal groups: Group 1: received propofol in the cardioplegia, Group 2: received propofol injection in the aortic line before and after the aortic cross-clamp, and Group 3 (control group): patients without propofol in the cardioplegia or aortic line. All patients were subjected to full medical histories, physical examinations, routine tests, and echocardiography. Cardiac troponin T was measured before surgery and 4 times postoperatively.ResultsIn group 1, there was a significant improvement in troponin T level at the last reading compared with the control group (mean ± SD. of group 1 was 246.4 ± 131.4, mean ± SD. of group 3 was 317.0 ± 117.9,p = 0.031), denoting propofol's cardioprotective effect when added as a cardioplegia additive. In group 2, there was a significant improvement of troponin T level at the last reading compared with the group 1 and control group (mean ± SD. of group 2 was 202.54 ± 156.03, mean ± SD. of group 3 was 317.0 ± 117.9,p < 0.001), denoting propofol's more cardioprotective effect when used systemically during cardiopulmonary bypass than when added as a cardioplegia additive.ConclusionsIn valvular cardiac surgery, propofol has an additional cardioprotective effect and a superior cardiac outcome when administered systematically during cardiopulmonary bypass rather than added to cardioplegia.Trial registrationPan African Clinical Trials Register PACTR201907764652028. Registered on 01 July 2019, retrospectively registered,https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID = 5726.
Scope and limitations of heritage-based resilience: some reflections from Nepal
Authors: Chapagain Neel Kamal 
Published: July 2023

AbstractRecent risk preparedness and recovery frameworks have focused in particular on the themes of heritage and resilience. It is generally agreed among heritage professionals that heritage can play an important role in postdisaster recovery and resilience. However, heritage (monuments or sites or even intangible heritage) in general is perceived as a fragile resource that needs to be saved instead of as a source of resilience. This raises a question on what resilience means for the conceptualisation of heritage – is it about ‘building back’ the same heritage there was before, or is it also about making heritage relevant to the changed situation (due to disaster etc.)? Is resilience an inherent quality of heritage, or can it also be a process for reconsidering heritage in the postdisaster period? Instead of pursuing heritage as a passive recipient of any response and resilience building process, we can ask (i) how heritage provides refuge in times of crisis, (ii) how heritage can be an agent of distress in some situations, and (iii) what heritage and resilience mean together. Scholars have begun to raise questions about the meaning of heritage for building resilience and the meaning of resilience in relation to heritage. Taking built heritage as an example, while many aspects of built heritage, such as construction techniques, open spaces or resilient materials, may contribute to resilience and recovery, there are also situations where narrow streets and dense built fabric add to disaster risks. Similar dilemmas may be observed in the case of intangible heritage associated with urban areas and everyday life. Thus, this paper challenges the romanticisation of heritage values and explores rationales and critical perspectives that will enable us to conceptualise heritage as a potential source of resilience and recovery. By examining these critical issues, the paper hopes to help enhance the notion of heritage-based urban resilience and recovery rather than loosely promoting it. In doing so, references are made to global frameworks as well as local realities related to the 2015 earthquakes in Nepal.
A case of bronchiolar adenoma/ciliated muconodular papillary tumor in the pulmonary center with high FDG accumulation on PET
Authors: Yamashita Naoki , Hirata Tomomi , Motoi Noriko , Iizuka Toshihiko , Kakuta Satoru , Yamazaki Nobuhiro , Nakajima Yuki , Kinoshita Hiroyasu , Akiyama Hirohiko 
Published: July 2023

Abstract
Background
Bronchiolar adenoma/ciliated muconodular papillary tumor (BA/CMPT) is listed in the World Health Organization (WHO) Classification 5th edition as a rare benign tumor with papillary growth of ciliary, goblet, and basal cells.

Case presentation
The patient was a 67-year-old female in whom a nodular shadow of 20 mm in diameter in the right lower lobe S10 center was found in chest computed tomography (CT) for examination of dorsal pain. Positron emission tomography/computed tomography (PET-CT) showed the accumulation of 18F-fluorodeoxyglucose (FDG) with a standardized uptake value (SUV)max of 13.0. Primary lung cancer was suspected, and surgery was scheduled as a therapeutic strategy. Thoracoscopic resection of the right lower lobe was performed, and possible BA/CMPT or adenocarcinoma was suggested in the differential diagnosis by the intra-perioperative rapid pathologic diagnosis. The final diagnosis was BA/CMPT. Histological findings indicated that the cause of the high FDG-PET scan might be due to many inflammatory cell infiltration in the tumor.

Conclusions
We report a resected case of BA/CMPT with exceptionally high FDG accumulation in PET.
A view of coherent elastic neutrino-nucleus scattering
Authors: Cadeddu M. , Dordei F. , Giunti C. 
Published: July 2023

Abstract
We review the physics of coherent elastic neutrino-nucleus scattering and the results and perspectives for the measurements of the radius of the neutron distribution of the nucleus, of the weak mixing angle, and of new neutrino interactions due to physics beyond the Standard Model.
Uniform magnetic field on the relativistic spinless particles with constant rest mass in 2D polar space
Authors: Ortakaya Sami 
Published: July 2023

Abstract
We present a model for the interaction of relativistic spin-0 charged particles moving in a uniform magnetic field. In the absence of an improved perturbative approach, we solve Kummer's differential equation directly, including principal quantum numbers. As a functional approach to nuclear interaction, we consider relativistic particle bound states subject to a

interaction without an antiparticle regime. Within the approximation line to

, we have also improved the considerations of the

and

related to scalar and mass interactions. Moreover, we have found closeness in the introduced approximation scheme for a range of 0.5 to 1.0 fm. In this way, minimal coupling might also yield analytical energy spectra. Within the 2D spatial regime, we have also found that the energy levels of relativistic spin-0 particles increase with increasing interaction energy (i.e., the quantum well width decreases for given values). Additionally, energy levels increase with larger values of the uniform magnetic field. The charge distribution is also valid for the central interaction-confinement space.
On time: developmental timing within and across species
Authors: Garcia-Ojalvo Jordi , Bulut-Karslioglu Aydan 
Published: July 2023

ABSTRACT
Organisms across species differ in the relative size and complexity of their tissues to serve the specific purposes of the host. Correct timing is a crucial ingredient in the development of tissues, as reaching the right size and complexity requires a careful balance between cellular proliferation and differentiation. Premature or delayed differentiation, for instance, can result in tissue imbalance, malformation or malfunction. Despite seemingly rigid constraints on development, however, there is flexibility in both the timing and differentiation trajectories within and between species. In this Spotlight, we discuss how time is measured and regulated in development, and question whether developmental timing is in fact different between species.
Separation of transcriptional repressor and activator functions in Drosophila HDAC3
Authors: Tang Min , Regadas Isabel , Belikov Sergey , Shilkova Olga , Xu Lei , Wernersson Erik , Liu Xuewen , Wu Hongmei , Bienko Magda , Mannervik Mattias 
Published: July 2023

ABSTRACT
The histone deacetylase HDAC3 is associated with the NCoR/SMRT co-repressor complex, and its canonical function is in transcriptional repression, but it can also activate transcription. Here, we show that the repressor and activator functions of HDAC3 can be genetically separated in Drosophila. A lysine substitution in the N terminus (K26A) disrupts its catalytic activity and activator function, whereas a combination of substitutions (HEBI) abrogating the interaction with SMRTER enhances repressor activity beyond wild type in the early embryo. We conclude that the crucial functions of HDAC3 in embryo development involve catalytic-dependent gene activation and non-enzymatic repression by several mechanisms, including tethering of loci to the nuclear periphery.
Zika virus infection histories in brain development
Authors: Marcelino Bruna L. M. , dos Santos Brendha L. , Doerl Jhulimar G. , Cavalcante Samantha F. , Maia Sara N. , Arrais Nivia M. R. , Zin Andrea , Jeronimo Selma M. B. , Queiroz Claudio , Hedin-Pereira Cecilia , Sequerra Eduardo B. 
Published: July 2023

ABSTRACT
An outbreak of births of microcephalic patients in Brazil motivated multiple studies on this incident. The data left no doubt that infection by Zika virus (ZIKV) was the cause, and that this virus promotes reduction in neuron numbers and neuronal death. Analysis of patients' characteristics revealed additional aspects of the pathology alongside the decrease in neuronal number. Here, we review the data from human, molecular, cell and animal model studies attempting to build the natural history of ZIKV in the embryonic central nervous system (CNS). We discuss how identifying the timing of infection and the pathways through which ZIKV may infect and spread through the CNS can help explain the diversity of phenotypes found in congenital ZIKV syndrome (CZVS). We suggest that intraneuronal viral transport is the primary mechanism of ZIKV spread in the embryonic brain and is responsible for most cases of CZVS. According to this hypothesis, the viral transport through the blood–brain barrier and cerebrospinal fluid is responsible for more severe pathologies in which ZIKV-induced malformations occur along the entire anteroposterior CNS axis.