bluuebunny/crossref_metadata_2025_split huggingface dataset:
Тестування інформаційно-керуючої системи з різносенсорними каналами інформаційної взаємодії на основі методу прямого моделювання із зовнішнім еталоном
Authors: Kotov Denys , Klymenko Viktor 
Published: September 2023

Мета роботи: полягає в обґрунтуванні аналітичного підходу до моделювання процесу тестування класу інформаційно-керуючих систем з різносенсорними каналами інформаційної взаємодії в умовах впливу негаусових завад.
Метод дослідження: основним методом дослідження є метод прямого моделювання на основі теореми ортогональності для випадку сумісної системи із зовнішнім еталоном.
Результати дослідження: в роботі представлено результати моделювання процесу тестування класу інформаційно-керуючих систем з різносенсорними каналами інформаційної взаємодії в умовах впливу негаусових завад для випадку сумісної системи із зовнішнім еталоном на основі синтезованих аналітичних виразів.
Теоретична цінність: основними результатами дослідження за тематикою статті є: синтез аналітичної моделі процесу тестування класу інформаційно-керуючих систем з різносенсорними каналами інформаційної взаємодії в умовах впливу негаусових завад.
Рекомендації та перспективи впровадження досвіду іноземних держав в систему формування генезису розвитку кібертехнологій у сфері безпеки та оборони України
Authors: Semenenko Oleh , Ostrovskyi Serhii , Bondarenko Maksym , Vovk Yaroslav , Kutsenko Dmutro 
Published: September 2023

Мета роботи: полягає у розробленні рекомендацій та визначенні перспектив впровадження досвіду іноземних держав в систему формування генезису розвитку кібертехнологій у сфері безпеки та оборони України.
Метод дослідження: основними методами досліджень є методи аналізу та синтезу, методи воєнно-економічної теорії, методи оцінювання та співставлення, індукції та дедукції, методи математичної статистики.
Результати дослідження: визначено послідовність формування генезису кібертехнологій у сфері безпеки та оборони України; проведено огляд розвитку кібертехнологій у деяких країнах світу у сфері безпеки та оборони станом на кінець 2021 року в рамках позитивного досвіду для України; розкрито показники фінансування розвитку галузі кібертехнологій оборонної сфери та країни в цілому, які розкривають ставлення цих країн до пріоритетності розвитку кібертехнологій та відношення керівництва держави до цієї галузі; сформовано напрями подальших досліджень за тематикою формування генезису розвитку кібертехнологій у сфері оборони України.
Теоретична цінність дослідження: аналіз теоретичних та практичних аспектів досвіду іноземних держав в системі формування генезису розвитку кібертехнологій у сфері безпеки та оборони України дозволив сформувати загальні рекомендації щодо розвитку кібертехнологій в сфері безпеки та оборони Україні, а також визначити шляхи та строки їх практичної реалізації.
Тип статті: теоретичний, описовий, практичний, методичний.
Management and Society 5.0
Authors: Czapran Tomasz 
Published: September 2023

While technology and digital transformation are developing, today’s society is rapidly changing. In this context, current management and strategies are becoming outdated, which raises the need to adapt to new challenges and keep pace with innovation. One option that seeks to bring new solutions is the concept of Society 5.0 which combines technological progress and sustainable development, and attempts to achieve a balance between them, ensuring the well-being of all members of society.
Society 5.0 emphasises the creation of socially beneficial solutions, human needs, and improving the quality of life, not just economic growth. Successful implementation of this concept requires quality management that is open to new mindsets, strategies, and approaches to management with a focus on sustainability, innovation, and collaboration. In Industry 5.0, success depends more than ever on management’s ability to understand and address the challenges posed by new technologies. Therefore, it is necessary to think about the key skills and capabilities that a manager should have in order to successfully manage an organisation in the context of Society 5.0.
The aim of this paper is to analyse the challenges associated with the management and implementation of the Society 5.0 concept, as well as to identify strengths, weaknesses, opportunities, and threats in this area, and to provide an overview of the key factors for successful management in the context of Society 5.0. In the first part, the theoretical background of this paper will be set, which will be applied for the subsequent analysis. The theoretical part focuses specifically on the definition and description of Society 5.0, and the key elements of this concept. It also focuses on new approaches to management that are key to management in this area, as well as defines the role and importance of SWOT analysis in management and strategic planning.
Based on a comparative analysis of relevant sources, the SWOT analysis will be performed in the practical part as a tool for assessing strengths, weaknesses, opportunities, and threats in relation to the new concept of Society 5.0. The results of the analysis will be evaluated, summarised, and finally recommendations will be made. This text will be useful for managers and executives who want to better adapt themselves to the new era of digital transformation and sustainable development.
Character development of youth generation in facing global competition, Indonesia’s experience in the Jokowi era
Authors: Nugroho S. Budi  , Fauzia Gustarina Cempaka Timur  , Mhd Halkis  
Published: September 2023

Purpose: to reveal the phenomenon of the younger generation as the capital of a developing nation.
Method: analysis, synthesis, abstraction, generalization, specifically sociological method.
Findings: it has been proven that without strong nationalism and patriotism of the young generation, the country will be easily shaken by problems arising from both inside and outside, which will make it difficult to achieve the goals of national development.
Paper type: theoretical.
Recent progress in carbon dots for anti-pathogen applications in oral cavity
Authors: Jiang Yuying , Yin Chuqiang , Mo Jianning , Wang Xiaoyu , Wang Ting , Li Guotai , Zhou Qihui 
Published: September 2023

BackgroundOral microbial infections are one of the most common diseases. Their progress not only results in the irreversible destruction of teeth and other oral tissues but also closely links to oral cancers and systemic diseases. However, traditional treatment against oral infections by antibiotics is not effective enough due to microbial resistance and drug blocking by oral biofilms, along with the passive dilution of the drug on the infection site in the oral environment.Aim of reviewBesides the traditional antibiotic treatment, carbon dots (CDs) recently became an emerging antimicrobial and microbial imaging agent because of their excellent (bio)physicochemical performance. Their application in treating oral infections has received widespread attention, as witnessed by increasing publication in this field. However, to date, there is no comprehensive review available yet to analyze their effectiveness and mechanism. Herein, as a step toward addressing the present gap, this review aims to discuss the recent advances in CDs against diverse oral pathogens and thus propose novel strategies in the treatment of oral microbial infections.Key scientific concepts of reviewIn this manuscript, the recent progress of CDs against oral pathogens is summarized for the first time. We highlighted the antimicrobial abilities of CDs in terms of oral planktonic bacteria, intracellular bacteria, oral pathogenic biofilms, and fungi. Next, we introduced their microbial imaging and detection capabilities and proposed the prospects of CDs in early diagnosis of oral infection and pathogen microbiological examination. Lastly, we discussed the perspectives on clinical transformation and the current limitations of CDs in the treatment of oral microbial infections.
Safety confirmation of induced pluripotent stem cell-derived cardiomyocyte patch transplantation for ischemic cardiomyopathy: first three case reports
Authors: Kawamura Takuji , Ito Yoshito , Ito Emiko , Takeda Maki , Mikami Tsubasa , Taguchi Takura , Mochizuki-Oda Noriko , Sasai Masao , Shimamoto Tomomi , Nitta Yukako , Yoshioka Daisuke , Kawamura Masashi , Kawamura Ai , Misumi Yusuke , Sakata Yasushi , Sawa Yoshiki , Miyagawa Shigeru 
Published: September 2023

IntroductionWith the expected increase in patients with heart failure and ischemic 15 cardiomyopathy, the development of myocardial regenerative medicine using cell transplantation as a novel treatment method is progressing. This first-in-human clinical trial aimed to confirm the safety of cardiomyocyte patch transplantation derived from allogeneic induced pluripotent stem (iPS) cells based on the results of several preclinical studies.Study designThe inclusion criteria were left ventricular ejection fraction of 35% or less; heart failure symptoms of New York Heart Association class III or higher despite existing therapies such as revascularization; and a 1-year observation period that included a 3-month immunosuppressive drug administration period after transplantation of iPS cell-derived cardiomyocyte patches to evaluate adverse events, cardiac function, myocardial blood flow, heart failure symptoms, and immune response.ResultsIn the first three cases of this trial, no transplanted cell-related adverse events were observed during the 1-year observation period, and improvement in heart failure symptoms was observed. In addition, improvements in left ventricular contractility and myocardial blood flow were observed in two of the three patients. Regarding immune response, an increase in transplant cell-specific antibody titer was observed in all three patients after immunosuppressive drug administration. In one patient with poor improvement in cardiac function and myocardial blood flow, an increase in antibody titer against HLA-DQ was observed even before cell transplantation.ConclusionsOur case findings demonstrate that the transplantation of iPS cell-derived cardiomyocyte patches for ischemic cardiomyopathy can be safely performed; however, further investigation of the therapeutic effect and its relationship with an immune response is needed by accumulating the number of patients through continued clinical trials.
Effective superior vena cava isolation using a novel C-shaped approach
Authors: Chen Chun-Kai , Yu Chih-Chieh 
Published: September 2023

IntroductionSuperior vena cava (SVC) isolation has been proposed as part of the ablation strategy for atrial fibrillation. However, circumferential isolation of the SVC can lead to late-onset complications, such as SVC stenosis.MethodsWe describe a detailed observation of the SVC conduction pattern and present a newly developed approach for SVC isolation that involves creating a C-shaped non-circumferential ablation line while sparing the lateral segment.ResultsTwelve consecutive patients were included in the study, all of whom achieved bidirectional block during the ablation procedure.DiscussionThis approach to SVC isolation is effective and has the potential to reduce ablation related complications; however, larger studies and long-term follow-up is warranted to confirm these findings.
Sepsis-induced coagulopathy is associated with new episodes of atrial fibrillation in patients admitted to critical care in sinus rhythm
Authors: Ortega-Martorell Sandra , Olier Ivan , Johnston Brian W. , Welters Ingeborg D. 
Published: September 2023

BackgroundSepsis is a life-threatening disease commonly complicated by activation of coagulation and immune pathways. Sepsis-induced coagulopathy (SIC) is associated with micro- and macrothrombosis, but its relation to other cardiovascular complications remains less clear. In this study we explored associations between SIC and the occurrence of atrial fibrillation (AF) in patients admitted to the Intensive Care Unit (ICU) in sinus rhythm. We also aimed to identify predictive factors for the development of AF in patients with and without SIC.MethodsData were extracted from the publicly available AmsterdamUMCdb database. Patients with sepsis and documented sinus rhythm on admission to ICU were included. Patients were stratified into those who fulfilled the criteria for SIC and those who did not. Following univariate analysis, logistic regression models were developed to describe the association between routinely documented demographics and blood results and the development of at least one episode of AF. Machine learning methods (gradient boosting machines and random forest) were applied to define the predictive importance of factors contributing to the development of AF.ResultsAge was the strongest predictor for the development of AF in patients with and without SIC. Routine coagulation tests activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR) and C-reactive protein (CRP) as a marker of inflammation were also associated with AF occurrence in SIC-positive and SIC-negative patients. Cardiorespiratory parameters (oxygen requirements and heart rate) showed predictive potential.ConclusionHigher INR, elevated CRP, increased heart rate and more severe respiratory failure are risk factors for occurrence of AF in critical illness, suggesting an association between cardiac, respiratory and immune and coagulation pathways. However, age was the most dominant factor to predict the first episodes of AF in patients admitted in sinus rhythm with and without SIC.
Retinal microvasculature features in patients with migraine: a systematic review and meta-analysis
Authors: Pang Yulian , Cao Ting , Zhang Qinglin , Hu Haijian , Wang Zhiruo , Nie Jiahe , Jin Ming , Chen Guiping , Zhang Xu 
Published: September 2023

BackgroundMigraine is a central nervous system disorder involving neuronal and vascular factors. The brain has a close anatomical relationship with retinal vessels and similar regulatory processes, and the retinal vascular system is the only in vivo vessel that can be directly visualized, while optical coherence tomography angiography (OCTA) is an advanced retinal vascular imaging technique. In this study, OCTA was used to study the retinal vascular density (VD) and foveal avascular zone (FAZ) in migraine patients, which provided a theoretical basis for its use as a candidate for rapid and non-invasive diagnosis of migraine.MethodsPublished studies comparing retinal microvascular profiles between migraine patients and healthy controls were obtained by a comprehensive search of electronic databases. Nine studies were finally included, including 775 eyes (migraine group: 444 eyes, control group: 331 eyes). Pooled effect sizes were presented as standardized mean differences (SMDs) and 95% confidence intervals (CIs). Statistical analysis was performed using Review Manager software (version 5.30).ResultsThe combined results revealed that the superficial and deep macular whole enface VD (MWEVD) (superficial VD: SMD = −0.30, P = 0.0001; deep VD: SMD = −0.61, P = 0.02), superficial foveal VD (FVD) (SMD = −0.42, P = 0.03), deep parafoveal VD (PFVD) (SMD = −0.31, P = 0.002), and peripapillary VD (PVD) (SMD = −0.49, P = 0.002) were significantly reduced in migraine patients compared with healthy people. However, there was a significant increase in the area of the FAZ in migraine patients (SMD = 0.56, P &lt; 0.0001).ConclusionMigraine patients are prone to retinal microcirculation disorders, such as decreased blood vessel density and increased avascular area in the fovea. This provides a theoretical basis for OCTA as a candidate for rapid, non-invasive diagnosis of migraine.
Innovative multidimensional gait evaluation using IMU in multiple sclerosis: introducing the semiogram
Authors: Voisard Cyril , de l'Escalopier Nicolas , Vienne-Jumeau Aliénor , Moreau Albane , Quijoux Flavien , Bompaire Flavie , Sallansonnet Magali , Brechemier Marie-Laure , Taifas Irina , Tafani Camille , Drouard Eve , Vayatis Nicolas , Ricard Damien , Oudre Laurent 
Published: September 2023

BackgroundQuantifying gait using inertial measurement units has gained increasing interest in recent years. Highly degraded gaits, especially in neurological impaired patients, challenge gait detection algorithms and require specific segmentation and analysis tools. Thus, the outcomes of these devices must be rigorously tested for both robustness and relevancy in order to recommend their routine use. In this study, we propose a multidimensional score to quantify and visualize gait, which can be used in neurological routine follow-up. We assessed the reliability and clinical coherence of this method in a group of severely disabled patients with progressive multiple sclerosis (pMS), who display highly degraded gait patterns, as well as in an age-matched healthy subjects (HS) group.MethodsTwenty-two participants with pMS and nineteen HS were included in this 18-month longitudinal follow-up study. During the follow-up period, all participants completed a 10-meter walk test with a U-turn and back, twice at M0, M6, M12, and M18. Average speed and seven clinical criteria (sturdiness, springiness, steadiness, stability, smoothness, synchronization, and symmetry) were evaluated using 17 gait parameters selected from the literature. The variation of these parameters from HS values was combined to generate a multidimensional visual tool, referred to as a semiogram.ResultsFor both cohorts, all criteria showed moderate to very high test–retest reliability for intra-session measurements. Inter-session quantification was also moderate to highly reliable for all criteria except smoothness, which was not reliable for HS participants. All partial scores, except for the stability score, differed between the two populations. All partial scores were correlated with an objective but not subjective quantification of gait severity in the pMS population. A deficit in the pyramidal tract was associated with altered scores in all criteria, whereas deficits in cerebellar, sensitive, bulbar, and cognitive deficits were associated with decreased scores in only a subset of gait criteria.ConclusionsThe proposed multidimensional gait quantification represents an innovative approach to monitoring gait disorders. It provides a reliable and informative biomarker for assessing the severity of gait impairments in individuals with pMS. Additionally, it holds the potential for discriminating between various underlying causes of gait alterations in pMS.
Differentiation between bipolar disorder and major depressive disorder in adolescents: from clinical to biological biomarkers
Authors: Yang Ruilan , Zhao Yanmeng , Tan Zewen , Lai Juan , Chen Jianshan , Zhang Xiaofei , Sun Jiaqi , Chen Lei , Lu Kangrong , Cao Liping , Liu Xuemei 
Published: September 2023

BackgroundMood disorders are very common among adolescents and include mainly bipolar disorder (BD) and major depressive disorder (MDD), with overlapping depressive symptoms that pose a significant challenge to realizing a rapid and accurate differential diagnosis in clinical practice. Misdiagnosis of BD as MDD can lead to inappropriate treatment and detrimental outcomes, including a poorer ultimate clinical and functional prognosis and even an increased risk of suicide. Therefore, it is of great significance for clinical management to identify clinical symptoms or features and biological markers that can accurately distinguish BD from MDD. With the aid of bibliometric analysis, we explore, visualize, and conclude the important directions of differential diagnostic studies of BD and MDD in adolescents.Materials and methodsA literature search was performed for studies on differential diagnostic studies of BD and MDD among adolescents in the Web of Science Core Collection database. All studies considered for this article were published between 2004 and 2023. Bibliometric analysis and visualization were performed using the VOSviewer and CiteSpace software.ResultsIn total, 148 publications were retrieved. The number of publications on differential diagnostic studies of BD and MDD among adolescents has been generally increasing since 2012, with the United States being an emerging hub with a growing influence in the field. Boris Birmaher is the top author in terms of the number of publications, and the Journal of Affective Disorders is the most published journal in the field. Co-occurrence analysis of keywords showed that clinical characteristics, genetic factors, and neuroimaging are current research hotspots. Ultimately, we comprehensively sorted out the current state of research in this area and proposed possible research directions in future.ConclusionThis is the first-ever study of bibliometric and visual analyses of differential diagnostic studies of BD and MDD in adolescents to reveal the current research status and important directions in the field. Our research and analysis results might provide some practical sources for academic scholars and clinical practice.
Comprehensive analysis of Cuproplasia and immune microenvironment in lung adenocarcinoma
Authors: Kuang Junjie , Zheng Zemao , Ma Wen , Zeng Shaohui , Wu Dehua , Weng Xie , Chen Yuming 
Published: September 2023

Background: Trace elements such as copper are essential for human health. Recently the journal Nat Rev Cancer has put forward the concept of Cuproplasia, a way of promoting tumor growth through reliance on copper. We attempted to conduct a comprehensive analysis of Cuproplasia-related genes in lung adenocarcinoma (LUAD) to explore the mechanism of action of Cuproplasia-related genes in LUAD.Method: Transcriptome data and clinical information of LUAD were obtained from TCGA-LUAD and GSE31210, and prognostic models of Cuproplasia-related genes were constructed and verified by regression analysis of GSVA, WGCNA, univariate COX and lasso. The signal pathways affected by Cuproplasia-related genes were analyzed by GO, KEGG and hallmarK pathway enrichment methods. Five immunocell infiltration algorithms and IMVIGOR210 data were used to analyze immune cell content and immunotherapy outcomes in the high-low risk group.Results: In the results of WGCNA, BROWN and TURQUOISE were identified as modules closely related to Cuproplasia score. In the end, lasso regression analysis established a Cuproplasia-related signature (CRS) based on 24 genes, and the prognosis of high-risk populations was worse in TCGA-LUAD and GSE31210 datasets. The enrichment analysis showed that copper proliferation was mainly through chromosome, cell cycle, dna replication, g2m checkpoint and other pathways. Immunoinfiltration analysis showed that there were differences in the content of macrophages among the four algorithms. And IMVIGOR210 found that the lower the score, the more effective the immunotherapy was.Conclusion: The Cuproplasia related gene can be used to predict the prognosis and immunotherapy outcome of LUAD patients, and may exert its effect by affecting chromosome-related pathways and macrophages.