bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical impact of minimal residual disease and genetic subtypes on the prognosis of childhood acute lymphoblastic leukemia
Authors: Yu Chih‐Hsiang , Jou Shiann‐Tarng , Su Ying‐Hui , Coustan‐Smith Elane , Wu Gang , Cheng Chao‐Neng , Lu Meng‐Yao , Lin Kai‐Hsin , Wu Kang‐Hsi , Chen Shu‐Huey , Huang Fang‐Liang , Chang Hsiu‐Hao , Wang Jinn‐Li , Yen Hsiu‐Ju , Li Meng‐Ju , Chou Shu‐Wei , Ho Wan‐Ling , Liu Yen‐Lin , Chang Chia‐Ching , Lin Ze‐Shiang , Lin Chien‐Yu , Chen Hsuan‐Yu , Ni Yu‐Ling , Lin Dong‐Tsamn , Lin Shu‐Wha , Yang Jun J. , Ni Yen‐Hsuan , Pui Ching‐Hon , Yu Sung‐Liang , Yang Yung‐Li 
Published: December 2022

AbstractBackgroundThis study analyzed data from two consecutive protocols for children newly diagnosed with acute lymphoblastic leukemia (ALL) to determine the clinical impact of minimal/measurable residual disease (MRD) and recently identified tumor genetic subtypes.MethodsGenetic subtypes were determined by sequential approaches including DNA indexing, reverse transcriptase–polymerase chain reaction, multiplex ligation‐dependent probe amplification, and RNA‐sequencing. MRD was assessed by flow cytometry. The Taiwan Pediatric Oncology Group TPOG‐ALL‐2013 study enrolled patients who received MRD‐directed therapy.ResultsThe 5‐year event‐free survival (EFS) and overall survival rates in the 2013 cohort were 77.8% and 86.9% compared to those of the 2002 cohort, which were 62.4% and 76.5%. Among patients treated with MRD‐guided therapy, those with ETV6‐RUNX1 fusion and high hyperdiploidy had the highest 5‐year EFS (91.4% and 89.6%, respectively). The addition of dasatinib improved outcomes in patients with BCR‐ABL1 ALL. Recently identified subtypes like DUX4‐rearranged, ZNF384‐rearranged, MEF2D‐rearranged, and PAX5alt subtypes were frequently positive for MRD after remission induction, and these patients consequently received intensified chemotherapy. Treatment intensification according to the MRD improved the outcomes of patients presenting DUX4 rearrangements. In high‐risk or very‐high‐risk subtypes, the TPOG‐ALL‐2013 regimen did not confer significant improvements compared to TPOG‐ALL‐2002, and the outcomes of BCR‐ABL1‐like, MEF2D‐rearranged, and KMT2A‐rearranged ALL subtypes (in addition to those of T‐cell ALL) were not sufficiently good. Novel agents or approaches are needed to improve the outcomes for these patients.ConclusionsThe TPOG‐ALL‐2013 study yielded outcomes superior to those of patients treated in the preceding TPOG‐ALL‐2002 study. This study provides important data to inform the design of future clinical trials in Taiwan.Plain language summary

MRD‐directed therapy improved the outcomes for pediatric ALL, especially standard‐risk patients.

Genomic analyses and MRD might be used together for risk‐directed therapy of childhood ALL.

Our work provides important data to inform the design of future clinical trials in Taiwan
Surgical outcomes and factors associated with postoperative complications of colorectal cancer in a Colombian Caribbean population: Results from a regional referral hospital
Authors: Dagobeth Edgar Ernesto Vergara , Rojas Gian Alberto Núñez , Valdelamar Juan Carlos Hoyos , Lozada‐Martínez Ivan David , Causado Amileth Suarez , Narvaez‐Rojas Alexis Rafael 
Published: December 2022

AbstractIntroductionColorectal cancer is the most common malignant neoplasm of the gastrointestinal tract. Its incidence and mortality vary markedly at a global level. Assessing the epidemiological behavior of this condition allows reevaluating diagnostic, therapeutic and prognostic options, based on new findings. In Colombia, few studies have correlated variables associated with surgical and oncological outcomes in this type of cancer. Then, the aim of this study was to evaluate the surgical outcomes and factors associated with postoperative complications of colorectal cancer in a Colombian Caribbean Population.MethodsRetrospective cross‐sectional study, including patients with a histopathological diagnosis of colorectal cancer who underwent open or laparoscopic surgery, during a period of two years (2018–2020), from a regional referral hospital. Clinical history variables were collected. Frequencies and prevalence ratios were calculated.ResultsA total of 84 patients were finally included. Adenocarcinoma of non‐special type with advanced clinical stages was the most prevalent (72.6%). Rectal neoplasia (45.2%) was the most frequent anatomical subsite, followed by proximal colon (p = 0.026). The anatomical subsite of the neoplasm, intraoperative complication (PR 1.38; 95% CI, 1.21–1.59, p = 0.001) and intensive care stay (PR 1.062; 95% CI, 1.01–1.12, p = 0.048) were associated with postoperative outcome.ConclusionsThe anatomical subsite of the neoplasm location, the presence of intraoperative complications and the stay in intensive care may be associated with the surgical and oncological outcome of individuals with colon cancer from the Colombian Caribbean region.
Identification and cloning of early senescence leaf mutant esl13 in rice (Oryza sativa L.)
Authors: Zhang Yingying , Chen Xinlong , Du Dan , Ma Lu , He Guanghua 
Published: December 2022

AbstractSenescence in plants is a complex and highly regulated process. However, the early senescence of leaf directly affects crop yield and quality. Identifying early senescence mutants and understanding its mechanism are critical to crop genetic improvement. In this study, we isolated an early senescence mutant esl13 (early senescence leaf 13) by ethyl methane sulfonate mutagenesis of Xinong 1B. Under paddy field conditions, the leaves of esl13 are normal green at the tillering stage, yellow at the booting stage, and gradually extended to the base of the leaves, and the senescence was most severe at the mature stage. At the booting stage, the leaves of mutant showed significantly lower photosynthetic pigment content, weaker chloroplast autofluorescence, and a highly significant reduction in net photosynthetic rate, resulting in shorter plants heights, shorter spike length, and lower seed yield at the mature stage. Similarly, the activity of antioxidant enzymes catalase, superoxide dismutase, and peroxidase decreased continuously, and malondialdehyde and superoxide anion (O2−) accumulated in the mutant esl13. Genetic analysis showed that the leaf senescence phenotype of esl13 is controlled by a single recessive nuclear gene, which was fine mapped between two molecular markers insertion‐deletion 4‐4 and SNP220 on chromosome 4. Gene sequencing showed that the 1230th base starting from ATG of the candidate gene LOC_Os04g48530 changed from T to A, causing the encoded amino acid change. Genetic complementation experiments confirmed the gene LOC_Os04g48530 controlled the mutant phe notype. This research provides new clues for further elucidating the regulation mechanism of rice senescence.
Ethnobotanical notes and pharmacological overview of traditional plant: Adhatoda vasica
Authors: Biharee Avadh , Bhartiya Sudha , Dubey Dheeraj , Yadav Raju P. , Sharma Arun , Pathak Sachchidanand , Chaudhary Anu , Yadav Arpita 
Published: December 2022

AbstractBackgroundAdhatoda vasica (Nees.) of the Acanthaceae family has excellent medicinal properties. It is a crucial ingredient in a number of formulations that have been used for decades in India to treat a wide range of health‐related difficulties, including fever, jaundice, headaches, colds, cough, whooping cough, asthma, dyspnea, phthisis, chronic bronchitis, and diarrhea. In our country (India) and other countries, the A. vasica plant has great medicinal importance. In the Ayurveda system of treatment, this plant is frequently employed.AimThe aim of this comprehensive study is to provide updated information on the phytochemical and pharmacological activity of A. vasica.ObjectivesThe stated objectives are to collect systematic data on the botanical description, phytochemistry, pharmacology, and toxicity of A. vasica, as well as detailed information on the many formulations that have conventionally been available on the Indian market.MethodThe relevant information was obtained from a variety of peer‐reviewed journals. Google Scholar, PubMed, ScienceDirect, and SciFinder were used to retrieve the journals.ResultA. vasica is a rich source of therapeutic agents that may have the potential to treat a variety of illnesses, while a detailed investigation of pharmacological activity is needed to confirm the contributing mechanism.ConclusionA. vasica is an important medicinal shrub, abundantly found across India, and a rich source of several alkaloids, terpenoids, carbohydrates, and terpenoids that may be used therapeutically in the medical system for treating a range of illnesses. It is a key ingredient in several Ayurvedic and Unani preparations available on the Indian market that are being used to treat a variety of illnesses.
Limited bedding nesting paradigm alters maternal behavior and pup's early developmental milestones but did not induce anxiety‐ or depressive‐like behavior in two different inbred mice
Authors: Pardo Grace V. E. , Alfaro Saca Eros Emanuel , Becerra Flores Christell Tatiana , Delgado Casós Walter Fares , Pacheco‐Otalora Luis F. 
Published: December 2022

AbstractAnimal models are crucial to understanding the mechanisms underlying the deleterious consequences of early‐life stress. Here, we aimed to examine the effect of the limited bedding nesting (LBN) paradigm on early life development milestones and anxiety‐ and/or depression‐like behavior in adolescent and adult mice from two inbred mice of both sexes. C57BL/6NCrl and BALB/c litters were exposed to the LBN paradigm postnatal day (PND) 2–9. Maternal behavior recording occurred on PND 3–9, and pups were weighed daily and examined to verify the eye‐opening on PND 10–22. The male and female offspring underwent evaluation in the open field test, elevated plus‐maze, and the forced swimming test during adolescence (PND 45–49) and adulthood (PND 75–79). We found that LBN impaired the maternal behavior patterns of both strain dams, mainly on C57BL/6NCrl strain. Also, LBN delayed the pup's eye‐opening time and reduced body weight gain, impacting C57BL/6NCrl pups more. We also found that LBN decreased anxiety‐related indices in adolescent and adult male but not female mice of both strains. Furthermore, LBN decreased depression‐related indices only adolescent female and male BALB/c and female but not male C57BL/6NCrl mice. These findings reinforce the evidence that the LBN paradigm impairs the maternal behavior pattern and pup's early developmental milestones but does not induce anxiety‐ or depressive‐like behavior outcomes during later life.
Age‐specific sensitivity analysis of stable, stochastic and transient growth for stage‐classified populations
Authors: Giaimo Stefano , Traulsen Arne 
Published: December 2022

AbstractSensitivity analysis in ecology and evolution is a valuable guide to rank demographic parameters depending on their relevance to population growth. Here, we propose a method to make the sensitivity analysis of population growth for matrix models solely classified by stage more fine‐grained by considering the effect of age‐specific parameters. The method applies to stable population growth, the stochastic growth rate, and transient growth. The method yields expressions for the sensitivity of stable population growth to age‐specific survival and fecundity from which general properties are derived about the pattern of age‐specific selective forces molding senescence in stage‐classified populations.
GHBS‐13 as an enhanced EAN‐13 barcode module for monitoring processed consumable products in Ghana
Authors: Siaw‐Yeboah Felix , Adebayo Felix Adekoya , Appiahene Peter , Weyori Benjamin Asubam 
Published: December 2022

AbstractWhen it comes to tracking goods from manufacturers to consumers, barcodes are useful instruments for monitoring and certifying their legitimacy. Because of its capacity to self‐validate all generated codes, the EAN‐13 is the most extensively used barcode for processed consumable products. Further investigations into the construction of the EAN‐13 barcode revealed that several additional components were required to make the EAN‐13 more credible for consumer use. Country code, production code, product code, and check digit make up the present EAN‐13 format. Meanwhile, the type of product and the number of times it has been manufactured are key components that must be included in the EAN‐13 barcode structure for barcode analysts to interpret. The study presented the GHBS‐13, an upgraded barcode structure that captured the two new components, namely, the product type and production count. The paper proposed a universal method called Tabiri Check Digit as a mathematical means of easily computing the check digit of the two barcodes. The formula was validated using EAN‐13 and GHBS‐13 barcodes, and the results were correct. The study also established a central point platform for customers to use to validate processed consumable products they buy in Ghana.
Care beyond Covid
Authors: Gary Mercer 
Published: December 2022

AbstractCare has become a popular topic of conversation in the context of Covid‐19. But what will it take for the value of care to be realized when the use of “care” in corporate slogans inspires cynicism or when conflicting appeals to care dilute the concept's meaning? In this brief essay, Hastings Center postdoctoral fellow Mercer Gary suggests that building helpfully on the current interest in care as an ethical value and a form of work requires strengthening the conditions that make care possible. Two projects on which Gary is collaborating at The Hastings Center concern supporting older adults in aging in place, with one demonstrating the necessity of stable housing and the other highlighting how the labor of informal care providers is often assumed, but not provided for, in aging‐in‐place initiatives.
Complex Decisions
Authors: Haupt Laura 
Published: December 2022

AbstractEssays and articles in the November‐December 2022 issue of the Hastings Center Report explore the complexities of medical decision‐making. A case‐study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked‐in syndrome should be asked her wishes about life‐sustaining interventions, and the articles illuminate the ethical value of the parental role in pediatric decision‐making, an array of ways in which patient decision‐making is interdependent, and the limitations of measures designed to evaluate the quality of a patient's decision and decision‐making process.
Critical success factors for school‐based integrated health care models: Learnings from an Australian example
Authors: Burman Charlotte , Mendoza Diaz Antonio , Leslie Andrew , Goldthorp Kristie , Jubb Brendan , Simms Aunty Ruth , Eapen Valsamma 
Published: December 2022

AbstractIssues AddressedIntegrated school‐based health services have the potential to address the unmet health needs of children experiencing disadvantage, yet these models remain poorly evaluated. The current article examines an integrated social and health care hub located on the grounds of a regional Australian public primary school, the Our Mia Mia Wellbeing Hub, to identify critical success factors for this service and others like it.MethodsSemi‐structured qualitative interviews were conducted with N = 55 multi‐sector stakeholders comprising parents, students, school staff, social and health care providers, and local Aboriginal community members. Interview transcripts were analysed according to a grounded theory approach.ResultsSix themes emerged from the analysis, reflecting important success factors for the model: service accessibility; service coordination; integration of education and health systems; trust; community partnerships; and perceptions of health.ConclusionsFindings highlighted Our Mia Mia as a promising model of care, yet also revealed important challenges for the service as it responds to the varied priorities of the stakeholders it serves.So What?Through capturing the perspectives of a large number of stakeholders, the current study provides valuable insight into key challenges and success factors for Our Mia Mia; these learnings can guide the development of other emerging school‐based health services and integrated care hubs.
Predictive factors of vaccination status, knowledge, attitudes, and practice towards prevention of hepatitis B infection among Bangladeshi people: A cross‐sectional study
Authors: Hosen Ismail , Moonajilin Mst. Sabrina , Hussain Nur 
Published: December 2022

AbstractBackground and AimsInfection with the hepatitis B virus is a serious public health problem that is growing all over the world. Therefore, in this context, there is no exception to public participation in disease burden reduction. Consequently, for the first time in Bangladesh, the current study aims to assess the level of vaccination status, knowledge, attitude, and practice of hepatitis B infection among general people.MethodsA cross‐sectional study was carried out between December 15, 2021, and January 17, 2022, including sociodemographic information as well as questions about vaccination status and knowledge, attitude, and practice related to hepatitis B. Data were analyzed using descriptive (frequency) and inferential statistics (Mann–Whitney U, Kruskal–Wallis H, χ2, binary logistic regression, and spearman's rho correlation coefficient).ResultsResults indicated that about one‐third (37.9%) of the 807 participants had received hepatitis B vaccine, with an overall mean score of 11.506 ± 5.403 for knowledge, 5.435 ± 1.038 and 4.252 ± 1.776 for attitude and practice, respectively. Risk factors related to vaccination were age, religion, educational qualification, occupation, residence area, marital status, comorbidity, and family member suffering from hepatitis B. Higher level of knowledge was significantly found among the young people aged between 10 and 29; had higher secondary or tertiary education (median = 13); were employed (median = 13.5, interquartile range [IQR] = 8); living in divisional city (median = 13, IQR = 7); were single (media = 13, IQR = 7); and whose family members were suffering from hepatitis B. Besides, poor practice was observed among those aged between 50 and higher (p = 0.004), had no formal education [p < 0.001), a retired or housewife (p < 0.001), divorced or widowed (p < 0.001), absence of comorbidity (p = 0.02), and whose family members were not infected with hepatitis B (p < 0.001).ConclusionsThe results exposed that vaccination rates and preventative behavior are unsatisfactory, which will hinder efforts to eradicate hepatitis B worldwide by the year 2030.
Barriers and facilitators of physical activity among school attending adolescents in Lagos State, Nigeria: A qualitative study exploring views and experiences of decision‐makers in secondary schools
Authors: Adebusoye Busola , Leonardi‐Bee Jo , Phalkey Revati , Chattopadhyay Kaushik 
Published: December 2022

AbstractBackground and AimsSchools represent a unique setting for promoting lifelong physical activity during critical development stages of life. Opportunities for in‐school physical activity largely depend upon school‐level policies, practices, and administrative support. A significant information gap exists on the factors influencing adolescents' participation in school‐based physical activity programs in Nigeria. This study aimed to identify and explore the barriers and facilitators of physical activity in school‐attending adolescents in Lagos State, Nigeria.MethodsA qualitative study, using semistructured interviews, was conducted to explore the views and experiences of 21 decision‐makers who were responsible for planning the physical and health education curriculum in secondary schools in Lagos State, Nigeria. Data were analyzed using the thematic analysis framework.ResultsEight themes were identified and explored. The barriers were (i) students' characteristics, (ii) parental objections, (iii) no prioritization of physical activity, (iv) insufficient resources, and (v) challenges with schools' initiatives. The facilitators were (vi) students' interests, (vii) students' awareness of benefits, and (viii) schools' initiatives.ConclusionOur study findings can help in designing interventions to increase physical activity among school‐attending adolescents in Lagos, Nigeria.
Market efficiency of the cryptocurrencies: Some new evidence based on price–volume relationship
Authors: Sahoo Pradipta Kumar , Sethi Dinabandhu 
Published: December 2022

AbstractCryptocurrencies have emerged as an important investment avenue in the past few years. Investors are increasingly interested in these currencies amid surging financial returns. In this context, understanding market efficiency of cryptocurrency has become very crucial for investors and academicians. The price–volume framework is a popular approach in financial economics to understand the market efficiency of stocks in the stock markets. Therefore, this article examines the market efficiency of cryptocurrencies through price–volume framework to understand whether crypto market is predictable. Towards this objective, data on both return and trading volume (TV) of the top eight cryptocurrencies are used for the period 8 August 2015–20 October 2022. As an empirical method, both linear and non‐linear causality models are used to validate the hypothesis. Our results confirm that TV cannot predict the cryptocurrencies' return, thereby validating the market efficiency hypothesis. Furthermore, we divide the sample according to the structural break period. The result from the post‐break period analysis also confirms the presence of market efficiency in the recent period for all currencies, barring XRP, XMR and DASH.
Implementation of variable gain controller based improved phase locked loop approach to enhance power quality in autonomous microgrid
Authors: Kundu Sombir , Singh Madhusudan , Giri Ashutosh K. 
Published: December 2022

AbstractIn this paper, an energy storage system (ESS), solar photovoltaic (SPV) and wind‐driven self‐excited induction generator (SEIG) is being used to establish an autonomous microgrid (MG). A variable gain controller based improved phase locked loop (VGC‐IPLL) is implemented to detect phase angle and generate unit templates for implementing a power quality control scheme in an autonomous MG. This controller enables the system adaptability to input frequency deviations and quick response with reduced steady state error. The novelty of this work is the implementation of VGC‐IPLL based controller in MG which automatically varies the gain according to variation in error. An incremental conductance (IC) based peak power point tracking technique is implemented to harness peak power from an SPV. Further, An ESS is interfaced at dc link of the voltage source converter (VSC) to maintain the power equilibrium between the renewable energy sources (RES's) and the unbalanced load. A bi‐directional controller (BDC) provides dc link voltage regulation and manages the charging/discharging mode of an ESS. Moreover, an ESS provides real/reactive power support through VSC during the intermittent condition of RES's and consumes the unused power during light load conditions. The proposed control with VSC provides multi‐function such as harmonics abatement, real/reactive power support, regulation of dc link voltage, load balancing and minimizes the power quality issues of autonomous MG.