bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constitutionalism, populism, and the imaginary of the authentic polity: a socio‐legal analysis of European public spheres and constitutional demoicratization
Authors: PŘIBÁŇ JIŘÍ 
Published: August 2023

AbstractThe sociology of constitutionalism emphasizes the duality of constitutions as both power limitations and power enhancements. Following the socio‐legal perspective, this article focuses on the constitutional imaginary of the public sphere and distinguishes it from the imaginary of the authentic polity, in which the constituent power of the people is protected against the corrupting effect of representative institutions and technocratic bodies. The promise of authenticity is behind the recent resurgence of populism and the constitution of what Zygmunt Bauman describes as ‘explosive communities’. The final part of the article focuses on the transnational politics and law of the European Union (EU) and discusses its possible responses to the imaginaries of constitutional populism – most notably, the emergence of European public spheres and demoicracy. Without the constitutional imaginaries of an anti‐explosive transnational and democratically constituted community, further enhancement of the power of EU institutions will always lead to populist backlash at the national and local levels of its member states.
High expression of novel biomarker TBRG4 promotes the progression and invasion of oral squamous cell carcinoma
Authors: Ramasubramanian Abilasha , Ramani Pratibha , Kannan Balachander , Arumugam Paramasivam 
Published: August 2023

AbstractBackgroundTransforming growth factor β regulator 4 (TBRG4) is a potential prognostic indicator in various cancers, especially squamous cell carcinomas, and is associated with disease amelioration and poor outcomes. The study aimed to assess the expression pattern of TBRG4 in patients with operable oral squamous cell carcinoma (OSCC) to understand its role in tumour progression using indicators of disease outcome like tumour stage, grade, nodal metastasis, and pattern of invasion.MethodsTBRG4 expression was assessed by analyzing 51 cancer and adjacent non‐cancerous tissues of OSCC patients using quantitative real‐time PCR, and Western blot. TBRG4 expression was also analysed in The Cancer Genome Atlas Head–Neck Squamous Cell Carcinoma (TCGA‐HNSC) dataset using the UALCAN tool (http://ualcan.path.uab.edu/). The relationship between TBRG4 expression and the patient's prognosis was analysed using Kaplan–Meier plotter.ResultsBoth mRNA and protein levels of TBRG4 were significantly increased in OSCC tissues. The TBGR4 expression was significantly associated with advanced stages (III and IV) and the worst pattern of invasion (WPOI‐4 and 5). High TBRG4 expression was also significantly associated with reduced overall survival (p = 0.011). In addition, the analysis of TBRG4 gene expression and clinical data from TCGA, identified that TBRG4 was highly expressed in HPV negative OSCC patients and positively correlated with worst overall survival.ConclusionThe present study suggests that the high expression of TBRG4 might serve as a novel prognostic biomarker for HPV‐negative OSCC, which can be validated by future additional investigations in larger cohorts along with functional studies.
Brain and antennal transcriptomes of host ants reveal potential links between behaviour and the functioning of socially parasitic colonies
Authors: Stoldt Marah , Collin Erwann , Macit Maide Nesibe , Foitzik Susanne 
Published: August 2023

AbstractInsect social parasites are characterized by exploiting the hosts' social behaviour. Why exactly hosts direct their caring behaviour towards these parasites and their offspring remains largely unstudied. One hypothesis is that hosts do not perceive their social environment as altered and accept the parasitic colony as their own. We used the ant Leptothorax acervorum, host of the dulotic, obligate social parasite Harpagoxenus sublaevis, to shed light on molecular mechanisms underlying behavioural exploitation by contrasting tissue‐specific transcriptomes in young host workers. Host pupae were experimentally (re‐)introduced into fragments of their original, another conspecific, heterospecific or parasitic colony. Brain and antennal mRNA was extracted and sequenced from adult ants after they had lived in the experimental colony for at least 50 days after eclosion. The resulting transcriptomes of L. acervorum revealed that ants were indeed affected by their social environment. Host brain transcriptomes were altered by the presence of social parasites, suggesting that the parasitic environment influences brain activity, which may be linked to behavioural changes. Transcriptional activity in the antennae changed most with the presence of unrelated individuals, regardless of whether they were conspecifics or parasites. This suggests early priming of odour perception, which was further supported by sensory perception of odour as an enriched function of differentially expressed genes. Furthermore, gene expression in the antennae, but not in the brain corresponded to ant worker behaviour before sampling. Our study demonstrated that the exploitation of social behaviours by brood parasites correlates with transcriptomic alterations in the central and peripheral nervous systems.
The effect of listening to music during continuous positive airway pressure on agitation levels and compliance of intensive care patients with COVID‐19: A randomized controlled trial
Authors: Bilgili Sumeyye , Balci Akpinar Reva 
Published: August 2023

AbstractBackgroundAgitation and incompliance with the treatment may be observed in patients undergoing continuous positive airway pressure (CPAP), which may cause inadequate oxygenation, sedation, termination of CPAP or intubation of the patient.AimThis study was conducted to determine the effect of listening to music during CPAP on the agitation levels of intensive care patients who underwent CPAP as a result of COVID‐19 and their compliance with the treatment.Study designThis study was a prospective, randomized, controlled clinical trial. Seventy‐six intensive care patients with COVID‐19 were included in this study and assigned to the music and control groups via the block randomization method. The study was completed with 70 patients. The patients and outcome assessors were not blinded in this study. The Richmond Agitation and Sedation Scale (RASS) level, respiratory rate, oxygen saturation (SpO2) and mask air leakage amount were the outcome measures.ResultsThe mean RASS score of the patients in the intervention group was 2.14 ± 0.69 before CPAP, 1.63 ± 064 at the 1st minute, 0.89 ± 0.58 at the 15th minute and 0.74 ± 0.61 at the 30th minute. The mean RASS score of the patients in the control group was 2.06 ± 0.53 before CPAP, 1.80 ± 0.58 at the 1st minute, 1.43 ± 0.60 at the 15th minute and 1.46 ± 0.61 at the 30th minute of CPAP. There was a statistically significant difference between the groups at the 15th and 30th minutes (t = −3.81, p < .001; t = −4.89, p < .001 respectively). The mean respiratory rate, SpO2 and mask air leakage amount were compared between the groups. There was a statistically significant difference in favour of the intervention group at the 15th minute (t = −2.47, p < .001; t = 2.57, p < .001; t = 2.93, p < .001 respectively) and 30th minute (t = −3.17, p < .001; t = 3.46, p < .001; t = −3.93, p < .001 respectively).ConclusionsThe study results show that listening to music during CPAP reduces the agitation levels of patients and helps them comply with the treatment.Relevance to clinical practiceMusic may be a beneficial application for patients who are agitated and unable to comply with CPAP therapy. This is an easy and applicable method, which can protect patients from the adverse effects of failed CPAP.
Rethinking the potential productivity of crassulacean acid metabolism by integrating metabolic dynamics with shoot architecture, using the example of Agave tequilana
Authors: Wang Yu , Smith J. Andrew C. , Zhu Xin‐Guang , Long Stephen P. 
Published: August 2023

Summary
Terrestrial CAM plants typically occur in hot semiarid regions, yet can show high crop productivity under favorable conditions.
To achieve a more mechanistic understanding of CAM plant productivity, a biochemical model of diel metabolism was developed and integrated with 3‐D shoot morphology to predict the energetics of light interception and photosynthetic carbon assimilation.
Using Agave tequilana as an example, this biochemical model faithfully simulated the four diel phases of CO2 and metabolite dynamics during the CAM rhythm. After capturing the 3‐D form over an 8‐yr production cycle, a ray‐tracing method allowed the prediction of the light microclimate across all photosynthetic surfaces. Integration with the biochemical model thereby enabled the simulation of plant and stand carbon uptake over daily and annual courses.
The theoretical maximum energy conversion efficiency of Agave spp. is calculated at 0.045–0.049, up to 7% higher than for C3 photosynthesis. Actual light interception, and biochemical and anatomical limitations, reduced this to 0.0069, or 15.6 Mg ha−1 yr−1 dry mass annualized over an 8‐yr cropping cycle, consistent with observation. This is comparable to the productivity of many C3 crops, demonstrating the potential of CAM plants in climates where little else may be grown while indicating strategies that could raise their productivity.
Density estimation and regression analysis on hyperspheres in the presence of measurement error
Authors: Jeon Jeong Min , Van Keilegom Ingrid 
Published: August 2023

AbstractThis paper studies density estimation and regression analysis with data observed on a general unit hypersphere and contaminated by measurement errors. We establish novel density and regression estimators, and study their asymptotic properties such as the rates of convergence and asymptotic normality. We also provide two types of asymptotic confidence intervals for both density and regression functions. One type is based on the asymptotic normality of their estimators and the other type is based on the empirical likelihood technique. We present practical details on the implementation of our method as well as simulation studies and real data analysis.
Seismic anisotropy indicates organized melt beneath the Mid-Atlantic Ridge aids seafloor spreading
Authors: Kendall J.M. , Schlaphorst D. , Rychert C.A. , Harmon N. , Agius M. , Tharimena S. 
Published: August 2023

Abstract
Lithospheric plates diverge at mid-ocean ridges and asthenospheric mantle material rises in response. The rising material decompresses, which can result in partial melting, potentially impacting the driving forces of the system. Yet the geometry and spatial distribution of the melt as it migrates to the ridge axis are debated. Organized melt fabrics can cause strong seismic anisotropy, which can be diagnostic of melt, although this is typically not found at ridges. We present anisotropic constraints from an array of 39 ocean-bottom seismometers deployed on 0–80 Ma lithosphere from March 2016 to March 2017 near the equatorial Mid-Atlantic Ridge (MAR). Local and SKS measurements show anisotropic fast directions away from the ridge axis, which are consistent with strain and associated fabric caused by plate motions with short delay times, δt (&lt;1.1 s). Near the ridge axis, we find several ridge-parallel fast splitting directions, φ, with SKS δt that are much longer (1.7–3.8 s). This is best explained by ridge-parallel sub-vertical orientations of sheet-like melt pockets. This observation is much different than anisotropic patterns observed at other ridges, which typically reflect fabric related to plate motions. One possibility is that thicker sub-ridge lithosphere with steep sub-ridge topography beneath slower spreading centers focuses melt into vertical, ridge-parallel melt bands, which effectively weakens the plate. Associated buoyancy forces elevate the sub-ridge plate, providing greater potential energy and enhancing the driving forces of the plates.
Isolated pulmonary hydatid cyst
Authors: Beacom Sabrina , Nand Priya , Singh Parampreet , Harrison Anil 
Published: August 2023

Echinococcosis is primarily a disease of developing nations with poor medical infrastructure, where cohabitation with domesticated animals is common. These conditions, in conjunction with the inherent chronicity of the disease, lead to low rates of diagnosis and high morbidity. Robust surveillance is not readily available in communities with the highest disease burden.WHO classifications assist in diagnostic and treatment endeavours especially in countries where this disease is not commonly encountered. However, the understanding of the pathophysiology of echinococcosis and optimal treatment are still lacking in certain patient populations.We present the case of a female from Central Asia with an isolated pulmonary hydatid cyst. She was diagnosed several months after she had an uncomplicated pregnancy and gave birth to a healthy baby girl. Due to a delay in surgical intervention, our patient received a prolonged course of treatment which resulted in a significant reduction in the size of the cyst. Given her improvement, we questioned the current guidelines set by the WHO regarding surgical resection of pulmonary hydatid cysts, compared with an extended course with albendazole in patients with an unusual and protracted course of the disease. Furthermore, we discuss the possible role of pregnancy in exacerbating symptoms of underlying pulmonary hydatid disease.
Rheumatoid factor isotypes in rheumatoid arthritis diagnosis and prognosis: a systematic review and meta-analysis
Authors: Motta Francesca , Bizzaro Nicola , Giavarina Davide , Franceschini Franco , Infantino Maria , Palterer Boaz , Sebastiani Gian Domenico , Selmi Carlo 
Published: August 2023

ObjectiveThe first biomarker associated with the rheumatoid arthritis is rheumatoid factor (RF) and since the earliest reports a role has been proposed in the diagnosis and in the prediction of clinical features and outcome. The study of RF isotypes has further attempted to improve diagnostic accuracy and identify specific subgroups of patients. The main objective of this study is to provide an analysis of the literature on the role of RF isotypes in the diagnosis and prognosis of rheumatoid arthritis (RA).MethodsWe performed a systematic literature review and meta-analysis on the role of RF isotypes in RA (only in English, from PubMed, search terms: “rheumatoid factor isotypes”, “diagnosis”, “prognosis” and “rheumatoid arthritis”, last search 31 July 2022, two independent assessment of quality and biases, results included in tables and in the meta-analysis).ResultsThirty-six articles were examined (7517 patients). Testing all RF isotypes with latex test or nephelometry allows for the highest sensitivity (68.6%, 95% CI 66.2% to 71.0%); nonetheless, the determination of IgA isotype provides the highest specificity (91.4%, 95% CI 90.8% to 92.0%) and the highest positive likelihood ratio (7.7, 95% CI 5.7 to 10.4). When testing IgM isotype the highest diagnostic OR (21.7, 95% CI 16.1 to 29.3) is reached. When analysing anti-citrullinated protein antibodies, RF isotype determination increases diagnostic accuracy. On the other hand, these do not provide relevant prognostic information, as results are conflicting.ConclusionsTesting RF allows the highest sensitivity, while IgA isotype the highest specificity and positive likelihood ratio for RA diagnosis. On the other hand, determination of RF isotypes dose not allow prognostic information, as data are limited and heterogeneous.
Performance evaluation of petroleum hard pitch modified with rice straw bio-oil
Authors: Verma Muskan , Gottumukkala Bharath , Behl Ambika , Thallada Bhaskar , Kakade Vijay , Kumar Jitendra 
Published: August 2023

In this present study, bio-binder was made using the bio-oil obtained from rice straw and petroleum hard pitch to reduce the air pollution caused by the burning of waste rice straw in the field. The physical, rheological, and chemical tests were conducted on the viscosity-grade binders (VG30 and VG40), petroleum hard pitch, and bio-binders prepared with a blending of petroleum hard pitch with 20 and 30 wt.%. The performance of bituminous mixes made with viscosity-grade binders and bio-binder was evaluated by using the dynamic creep, resilient modulus, and tensile strength tests. The results of the frequency sweep and Fourier transform infrared tests indicate that bio-binders have poor resistance to aging. The rut resistance of the bio-binder modified mix was better than that of the VG30 mix. There is no significant difference in moisture resistance of bituminous mixes prepared with bio-binder and viscosity-grade binders.
Domestic Digital Diplomacy: Digital Disruption at the Macro and Micro Levels
Authors: Manor Ilan 
Published: August 2023

Summary
Studies examining the digital disruption of diplomacy focus on the micro level of diplomats’ working routines. This article investigates the new practice of ‘domestic digital diplomacy’ to explore interactions between micro- and macro-level disruptions. The practice of domestic digital diplomacy stems from the digital disruption of government ministries that embrace an outward-looking stance. Domestic digital diplomacy also impacts society as diplomats create a prism through which citizens can make sense of their world. Few studies have investigated how ministries of foreign affairs (MFAs) create such a domestic prism. This study addresses this gap by analysing the images shared on Twitter by the British Foreign Office following Brexit. Using Barthes’s semiotic approach to image analysis, this study demonstrates that MFAs can use images to shape their citizens’ worldviews, values and beliefs. The study concludes that investigating digital disruption in diplomacy requires that scholars focus on interactions between micro- and macro-level disruptions.
The effectiveness of cognitive rehabilitation intervention with the telerehabilitation method for amnestic mild cognitive impairment: A feasibility randomized controlled trial
Authors: Torpil Berkan , Pekçetin Emel , Pekçetin Serkan 
Published: August 2023

Introduction Although different cognitive rehabilitation (CR) approaches have been developed for mild cognitive impairment (MCI), a standard method has not been determined for interventions, especially with the telerehabilitation (TR) method, which is one of the alternative solutions to the problems of accessing rehabilitation services. The study was planned to compare the effectiveness of the CR intervention applied in the older adults with amnestic-MCI with face-to-face and TR methods. Methods A total of 68 participants were randomly assigned to the TR and face-to-face groups. TR method was delivered by teleconference method in the participant's own home. A 12-week CR intervention was applied to both groups. Pre- and post-intervention cognitive skills of the participants were evaluated using the Loewenstein occupational therapy cognitive assessment-geriatric (LOTCA-G). Results Cognitive skills were increased in both groups ( p < 0.001). A statistically significant difference was observed between the groups in the post-intervention visual-spatial perception, praxis, and total LOTCA-G scores ( p < 0.01). Discussion It was determined that a 12-week CR program had positive effects on cognitive functions in the older adults with amnestic MCI. Both TR and face-to-face methods can be used in CR interventions for amnestic MCI. In addition, the TR method can be advantageous in terms of time and accessibility. Clinical trial number NCT05664984.
Mitigating inequity: ethically prioritizing patients for CAR T-cell therapy
Authors: Bell Jennifer A. H. , Jeffries Gregory A. , Chen Christine I. 
Published: August 2023

Abstract
Manufacturing capacity and institutional infrastructure to deliver chimeric antigen receptor T-cell therapies (CAR-T) are pressured to keep pace with the growing number of approved products and expanding eligible patient population for this potentially life-saving therapy. Consequently, many cell therapy programs must make difficult decisions about which patient should get the next available treatment slot. This situation requires an ethical framework to ensure fair and equitable decision-making. In this perspective, we discuss the application of Accountability for Reasonableness (A4R), a priority-setting framework grounded in procedural justice, to the problem of limited CAR-T slots at our institution. We formed a multidisciplinary working group spanning several hematological malignancies. Through multiple rounds of partner engagement, we used A4R guiding principles to identify 4 main criteria to prioritize patients for CAR-T: medical benefit, safety/risk of complications, psychosocial factors, and medical urgency. Associated measures/tools and an implementation process were developed. We discuss further how ethical principles of fairness and equity demand a consistent approach within health systems that does not disadvantage medically underserved or underrepresented populations and supports overcoming barriers to care. In our commitment to transparency and collaboration, we make our tools available to others, ideally to be used to engage in their own A4R process, adapting the tools to their unique environments. Our hope is that our preliminary work will support the advancement of further study in this area globally, aiming for justice in resource allocation for all potential CAR-T candidates, wherever they may seek care.
Investigation of the interaction between Genetic Risk Score (GRS) and fatty acid quality indices on mental health among overweight and obese women
Authors: Rasaei Niloufar , Samadi Mahsa , Khadem Alireza , Fatemi Seyedeh Fatemeh , Gholami Fatemeh , Mirzaei Khadijeh 
Published: August 2023

Abstract
Background & aims
Mental disorders are associated with dietary fatty acids and genome-wide association studies have found multiple risk loci robustly related to depression, anxiety, and stress. The aim of this study is to investigate the interaction of genetic risk score (GRS) and dietary fat quality indices on mental health.

Methods
This cross-sectional study included 279 overweight and obese women for N6/N3 ratio and 378 overweight and obese women for CSI aged 18–68 years. Using reliable and verified standard protocols, body composition, anthropometric indices, blood pressure, physical activity, and dietary fat quality were measured. Serum samples were used to determine biochemical tests. A genetic risk score (GRS) was calculated using the risk alleles of the three SNPs. A generalized linear model (GLM) was applied to assess the interactions between GRS and fat quality indices. Mental health was evaluated using Depression Anxiety Stress Scales (DASS-21).

Results
The mean (± SD) age and BMI of our participants were 36.48 (8.45) and 30.73 (3.72) kg/m2 respectively. There was a marginally significant mean difference among tertiles of the CSI in terms of stress (P = 0.051), DASS-21 (P = 0.078) in the crude model. After adjusting for age, energy intake, physical activity and BMI in model 1, there was a positive interaction between GRS and T3 of N6/N3 ratio on anxiety (β = 0.91, CI = 0.08,1.75, P = 0.031), depression (β = 1.05, CI = 0.06,2.04, P = 0.037), DASS-21 (β = 2.22, CI= -0.31,4.75, P = 0.086).

Conclusion
Our findings indicate that higher ratio of N-6 to N-3 considering genetics were predictive of mental disorder in our population.