bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jejunogastric intussusception associated with jejunojejunal intussusception (double telescoping) occurring 20 years after gastrojejunostomy
Authors: Atri souhaib , Hammami Mahdi , Sebai Amine , Aifia Rany , Brahim Meriem Ben , Chaker Youssef , Fteriche Fadhel Samir , Kacem Montassar 
Published: June 2023

Abstract
Introduction: Jejunogastric intussusception (JGI) is a rare but potentially lethal complication following gastrectomy or gastrojejunostomy surgeries. Diagnosis of this condition can be challenging due to its rarity and non-specific symptoms. This article presents a case report of a 60-year-old male with a history of trans mesocolic gastrojejunostomy who developed acute symptoms of JGI.
Case Report: The patient presented with acute epigastric pain, vomiting, and hematemesis. Physical examination and laboratory tests indicated dehydration, tachycardia, and leukocytosis. Computed tomography (CT) revealed intussuscepted loops within the stomach. Emergency laparotomy was performed, and the intussusception was manually reduced without the need for resection. The patient recovered well and was discharged five days post-surgery.
Discussion: Retrograde jejunogastric intussusception is a rare complication, often occurring years after gastric surgery. It can be classified into acute and chronic forms, with the former presenting with intense pain and potential hematemesis. The condition can arise in different surgical contexts and even spontaneously. The cause of JGI remains unclear, but factors such as hyperacidity, abnormal motility, and increased intra-abdominal pressure have been implicated. Diagnosis can be made through endoscopy or alternative imaging modalities such as CT. Surgical intervention is the treatment of choice, with various options available based on intraoperative findings.
Conclusion: Retrograde jejunogastric intussusception is challenging to diagnose and treat due to its rarity and lack of understanding of its causes. Imaging techniques and endoscopy play important roles in diagnosis, while surgery remains the primary treatment option. Vigilance is necessary among medical professionals to consider JGI in cases of acute abdominal pain and vomiting following gastric surgery, allowing for prompt diagnosis and intervention to prevent bowel necrosis. Further research is needed to establish optimal surgical strategies and evaluate recurrence rates.
Effects of microbial inoculants combined with maize straw on physicochemical properties and microbial community structure in black soil during soybean growth
Authors: HOU Tingting Dr. , Yu Deshui , du jie , li Meng , Zhang Ye , Meng Liqiang 
Published: June 2023

Abstract
Aim
Traditionally, increased crop yield has been supported by applying a large amount of chemical fertilizer. However, using excessive chemical fertilizers on soils diminishes soil fertility and crop yield while contaminating the ecological environment.
Method
To replace the fertilizer, microbial inoculants, and maize straws were introduced to the soil as environmental fertilizers in this study. During soybean cultivation, their effects on physicochemical properties, enzyme activity, and microbial community structure in the soil were investigated. Compared to fertilization alone, adding microbial inoculants mixed with maize straw (CSF) during soybean cultivation boosted agronomic traits such as soybean fresh weight, plant height, and stem thickness.
Result
This increased the physicochemical parameters of the soil, such as pH, available Potassium (AP), and water content, affecting the soil bacterial population. Bacteria abundance and diversity significantly increased, with acidobacter, Proteobacteria, Candidatus_ Solibacte, and Sphingomonas dominating. Redundancy analysis revealed that pH and AP were environmental factors that influenced microbial community structure. CSF boosted microbial diversity and community structure while increasing soybean yield from 3.91–5.46%.
Conclusion
In conclusion, soil improvement using maize straw and composite compound inoculants produced better outcomes. Our findings offer theoretical and experimental references for soil erosion.
Microglia Play an Important Role in PRV Infection-Induced Immune Responses of the Central Nervous System
Authors: Sun Xiuxiu , Jin Xinxin , Liu Xi , Wang Lumeng , Li Li , Yang Junjie , Feng Helong , Lin Zhengdan , Zhan Cunlin , Zhang Wanpo , Gu Changqin , Hu Xueying , Liu Xiaoli , Cheng Guofu 
Published: June 2023

Abstract
Pseudorabies virus (PRV) can infect multiple hosts and lead to fatal encephalitis. There is a significant increase in the number of microglia in the brain of animals infected with PRV. However, whether and how microglia contribute to central nervous system damage in PRV infection remain unknown. In the present study, we elucidated that PRV infection can cause more severe inflammatory cell infiltration, thicker and more numerous vessel sleeve walls, and more severe inflammatory responses in the brains of natural hosts (pigs) than in those of nonnatural hosts (mice). In a mice infection model, activated microglia restricted viral replication in the early stage of infection. Acute neuroinflammation caused by microglia hyperactivation at late-stage of infection. Furthermore, in vitro experiments revealed that microglia restricted viral replication and decreased viral infectivity. This may be associated with the phagocytic ability of microglia because we observed a significant increase in the expression of the membrane receptor TREM2 in microglia, which is closely related to phagocytosis, we observed that depletion of microglia exacerbated neurological symptoms, blood–brain barrier breakdown, and peripheral lymphocyte infiltration. Taken together, we revealed the dual role of microglia in protecting the host and neurons from PRV infection. IMPORTANCE PRV causes a neuro-virulent disease in natural and unnatural hosts which is often fatal. Microglial activation plays an important role in neuroinflammatory diseases. However, how microglia play a role in this process remains unclear. In this study, the differences of pathological changes between pigs and mice infected with PRV were compared. In a mice infection model, activated microglia restricted viral replication in the early stage of infection. Acute neuroinflammation caused by microglia hyperactivation at late-stage of infection. In vitro experiments revealed that microglia restricted viral replication and decreased viral infectivity. New therapeutics targeting microglia activation may help to treat PRV-associated neurocognitive disorders.
The Power of Princesses: How Disney's Female Characters Shape Girls' Identities
Authors: Singer Nermeen 
Published: June 2023

Abstract
This review article examines the profound influence of Disney's female characters, specifically princesses, on the identities of young girls. Drawing on a comprehensive analysis of literature, the article explores various dimensions through which these characters shape girls' understanding of themselves and the world around them. The findings highlight that Disney princesses serve as powerful role models for young girls, challenging traditional gender stereotypes and promoting positive values. They showcase traits beyond beauty and love interests, displaying resilience, intelligence, bravery, and independence. However, the article also acknowledges the controversies surrounding the portrayal of princesses and their potential negative effects. The article calls for a balanced approach, encouraging the embrace of empowering aspects while remaining critical and mindful of the limitations. By fostering media literacy and promoting inclusive narratives, society can harness the positive influence of Disney princesses to empower young girls and support their holistic development.
Sequence-specific interactions determine viscoelastic moduli and aging dynamics of protein condensates
Authors: Alshareedah Ibraheem , Borcherds Wade , Cohen Samuel , Farag Mina , Singh Anurag , Bremer Anne , Pappu Rohit , Mittag Tanja , Banerjee Priya 
Published: June 2023

Abstract

Biomolecular condensates that form via phase separation coupled to percolation are complex viscoelastic materials whose properties are thought to influence cellular functions and pathology. Here, we report results from measurements of sequence-encoded and age-dependent material properties of condensates formed by intrinsically disordered prion-like low complexity domains (PLCDs). Nascent PLCD condensates are viscoelastic Maxwell fluids, and their sequence-specific dynamical moduli are governed by the strengths of aromatic sticker-sticker interactions. These measured moduli are reproducible using a generalized Rouse-Zimm model that accounts for the computed inhomogeneous network-like structures of condensates. PLCD condensates can undergo physical aging that leads to dynamical arrest on sequence-specific timescales. However, contrary to being glass-like, the aged PLCD condensates are non-fibrillar, terminally elastic, Kelvin-Voigt solids. These results suggest that terminally viscous fluid states of condensates are metastable, whereas their terminally elastic solid states are globally stable. The timescales of fluid-to-solid transitions can be controlled by mutations to spacers that weaken the metastability of fluids. Taken together, our results suggest that sequence features of naturally occurring PLCDs enhance the metastabilities of terminally viscous condensates. This likely renders the barriers for conversion from fluids to solids to be insurmountable on timescales that are relevant to condensate functions in cells.
A holistic model of health inequalities for health policy and state administration: a case study in the regions of the Czech Republic
Authors: Hübelová Dana , Caha Jan , Janošíková Lenka , Kozumplíková Alice 
Published: June 2023

Abstract
Background Health inequities exist within and between societies at different hierarchical levels. Despite overall improvements in health status in European Union countries, disparities persist among socially, economically, and societally disadvantaged individuals. This study aims to develop a holistic model of health determinants, examining the complex relationship between various determinants of health inequalities and their association with health conditions.
Methods Health inequalities and conditions were assessed at the territorial level of Local Administrative Units (LAU1) in the Czech Republic. A dataset of 57 indicators was created, categorized into seven determinants of health and one health condition category. The necessary data were obtained from publicly available databases. Comparisons were made between 2001–2003 and 2016–2019. Various methods were employed, including composite indicator creation, correlation analysis, the Wilcox Test, aggregate index calculation, cluster analysis, and data visualization using the LISA method.
Results The correlation matrix revealed strong relationships between health inequality categories in both periods. The most significant associations were observed between Economic status and social protection and Education in the first period. However, dependencies weakened in the later period, approaching values of approximately 0.50. The Wilcox Test confirmed variations in determinant values over time, except for three specific determinants. Data visualization identified persistently adverse or worsening health inequalities in specific LAU1, focusing on categories such as Economic status, Education, Demographic situation, Environmental status, Individual living status, and Road safety and crime. The health condition indices showed no significant change over time, while the aggregate index of health inequalities improved with widened differences.
Conclusion Spatial inequalities in health persist in the Czech Republic, influenced by economic, social, demographic, and environmental factors, as well as local healthcare accessibility. Both inner and outer peripheries exhibit poor health outcomes, challenging the assumption that urban areas fare better. The combination of poverty and vulnerabilities exacerbates these inequalities. Despite the low rates of social exclusion and poverty, regional health inequalities persist in the long term. Effectively addressing health inequalities requires interdisciplinary collaboration and evidence-based policy interventions. Efforts should focus on creating supportive social and physical environments, strengthening the healthcare system, and fostering cooperation with non-medical disciplines.
Recognition of seismogenic sources using time-frequency analysis
Authors: Buitrago Alejandro Alzate , Saldaña Leonardo Cano , Monsalve Hugo 
Published: June 2023

Abstract
A characterization of seismic signals was carried out, using signal analysis techniques in the time-frequency domain, in order to identify the relevant characteristics of five seismic sources, excluding any knowledge of the seismogenic source and extracting and recognizing characteristic patterns that would allow classification of the earthquakes and to allow any possible qualitative explanation of a likely source that originated the event. For this purpose, a database consisting of 293 signals that were previously located and assigned to mentioned seismic sources. Finally, a basic classification system was designed through a neural network multilayer perceptron that assigns the earthquake to one of the seismic sources established according to the features and patterns that have been detected using time-frequency analysis.
The Effect of Manual Therapy on Psychological Factors and Quality of Life in Lumbar Disc Herniation Patients: A Single Blinded Randomized Clinical Trial
Authors: Taşkaya Burhan , Taşkent İsmail , Çakıllı³ Mahmut , Yılmaz⁴ Öznur 
Published: June 2023

Abstract
Background
The efficacy of manual therapy on psychological factors and quality of life in lumbar disc herniation patients has not been well studied.
Aim
This study aimed to investigate the effect of manual therapy on pain, kinesiophobia, pain catastrophizing, anxiety, depression and quality of life in patients with lumbar disc herniation (LDH).
Method
The study included 32 LDH patients. Patients were divided into Manual therapy group (MTG- age 39.81 ± 9.45 years) and Exercise group (EG- age 38.31 ± 9.21 years) by sealed envelope randomization. Patients were evaluated pre-study, post-study and 3-month period using the McGill-Melzack Pain Questionnaire (MMPQ), Hospital Anxiety and Depression Scale (HADS), Tampa Kinesiophobia Scale (TKS), Pain Catastrophizing Scale (PKS) and Notthingam Health Profile (NSP). The exercise group received a total of 10 sessions of stabilization exercises in 5 weeks, 2 sessions per week. In addition to stabilization exercises, mobilization applications including Anterior-Posterior Lumbar Spinal Mobilization, Lumbar Spinal Rotational Mobilization and Joint Mobilization in Lumbar Flexion Position were applied to the manual therapy group.
Results
It was found that HADS and TKS values decreased in the MTG group compared to the pre-treatment period (p < 0.05), while there was no difference between these values in the EG group (p > 0.05). There was a statistically significant difference in MMPQ, PCS and NHP values after treatment in both MTG and EG groups (p < 0.05).
Conclusion
It was found that manual therapy had positive effects on psychological factors such as pain, kinesiophobia, pain catastrophizing, anxiety, depression and quality of life in patients with LDH.
ClinicalTrials.gov Identifier: NCT05804357
Impact of Prophylactic Central Lymph Node Dissection on the Complications and Recurrence Rates in Papillary Thyroid Carcinoma — An AFCE (French-speaking Association of Endocrine Surgery) multicentre study based on the EUROCRINE® national data.
Authors: Chereau Nathalie , Christou Niki , Caiazzo Robert , Fouler Adrien Le , Lifante Jean christophe , Maillard Laure , Mirallie Eric , Pattou Francois , Bouviez Nicolas , Santucci Nicolas , Brunaud Laurent , Menegaux Fabrice 
Published: June 2023

Abstract
Purpose
Prophylactic central neck dissection (pCND) remains controversial during the initial surgery for preoperative and intraoperative node-negative (cN0) papillary thyroid carcinoma (PTC).
Methods
Patients undergoing thyroidectomy with or without pCND (Nx) for PTC in nine French surgical departments, registered in the EUROCRINE® national data in France between January 2015 and June 2021, were included in a cohort study. Demographic and clinicopathological characteristics, complications, and recurrence rates were compared using multivariate regression analysis.
Results
A total of 1,905 patients with cN0 PTC were enrolled, including 1,534 who had undergone pCND and 371 who hadn’t (Nx). Of these, 1,546 (81.2%) were female, and the median age was 49 years (range:15–89 years). Patients who had undergone pCND were more likely to have multifocal tumors (n = 524[34.2%] vs. n = 68[18.3%], p < 0.001) and larger tumors (15.3 mm vs. 10.2 mm, p = 0.01) than patients with Nx. Of the patients with pCND, 553 (36%) had positive central LN (N1a), with a median of 1 N1 (IQR 0–5). pCND was associated with a higher temporary hypocalcemia rate (n = 25 [8%] vs. n = 15 [4%], p < 0.001). The rates of permanent hypocalcemia and temporary and permanent recurrent laryngeal nerve (RLN) palsy were not significantly different between the two groups (p > 0.2). After adjusting for covariates (age, sex, multifocality, and pathological T stage) in a multivariable Cox PH model, the performance of lymph node dissection (pCND vs. no-pCND) was not associated with PTC recurrence (p = 0.2).
Conclusion
pCND in PTC does not reduce recurrence and is associated with a two-fold increase in the incidence of transient hypoparathyroidism. These data should be considered while issuing further guidelines regarding the treatment of patients with cN0 PTC.
Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients
Authors: Kaneko Tomonori , Ezra Sally , Abdo Rober , Voss Courtney , Zhong Shanshan , Liu Xuguang , Hovey Owen , Martin Claudio M. , Slessarev Marat , Nynatten Logan Robert , Ye Mingliang , Fraser Douglas , Li Shawn 
Published: June 2023

Abstract
The SARS-CoV-2 infection elicits comprehensive host immune reactions and causes severe diseases in some individuals. However, the molecular basis underlying the excessive, yet non-productive immune responses in severe COVID-19 is not fully understood. To address this, we compared the peripheral blood mononuclear cell (PBMC) proteome and phosphoproteome of sepsis patients positive or negative for SARS-CoV-2 and healthy subjects by quantitative mass spectrometry. We show here that the COVID-19 PBMC proteome and phosphoproteome undergo dynamic changes during disease progression, and the corresponding protein or phosphoprotein signatures can distinguish longitudinal disease states. Furthermore, SARS-CoV-2 infection leads to a global reprogramming of the kinome and the phosphoproteome, resulting in defective adaptive immune response mediated by B and T lymphocytes, compromised innate immune responses involving the SIGLEC and SLAM family of immunoreceptors, and excessive cytokine-JAK-STAT signaling. Besides uncovering the host proteome and phosphoproteome aberrations caused by SARS-CoV-2, our work has recapitulated several reported therapeutic targets for COVID-19 and identified numerous new ones, including the kinases PKG1, CK2, ROCK1/2, GRK2, SYK, JAK2/3, TYK2, DNA-PK and the cytokine IL-12. FUNDING. Ontario Research Fund (ORF)-COVID-19 Rapid Research Fund.
Inhibition of defect-induced α-to-δ phase transition for efficient and stable formamidinium perovskite solar cells
Authors: Chen Tian , Wen Ben , Yin Qixin , Lin Ruohao , Zhu Shengcai , Gao Pingqi , Xie Jiangsheng 
Published: June 2023

Abstract
Defects passivation has been widely devoted to improving the performance of formamidinium lead triiodide (FAPbI3) perovskite solar cells; however, the effect of various defects on the α-phase stability is still unclear. Here, using density functional theory, we first reveal the degradation pathway of the FAPbI3 perovskite from α to δ phase and investigate the effect of various defects on the energy barrier of phase transition. The simulation results predict that iodine vacancies are most likely to trigger the degradation, since they obviously reduce the energy barrier of α-to-δ phase transition and have the lowest formation energies at the perovskite surface. A water-insoluble PbC2O4 compact layer was introduced on the perovskite surface to largely suppress the α-phase collapse through hindering the iodine migration and volatilization. Furthermore, this strategy largely reduced the interfacial nonradiative recombination and boosted the efficiency of the solar cells to 25.39% (certified 24.92%). Unpackaged device can maintain 92% of its initial efficiency after operation at maximum power point under simulated air mass 1.5G irradiation for 550 h.
Genetic analysis of Indian patients with steroid-resistant nephrotic syndrome in children
Authors: Prasad Narayan , Dhanorkar Manoj , Kushwaha Ravi , Yadav Brijesh , Patel Manas , Kaul Anupama , Bhadauria Dharmendra , Behera Manas , Veeranki Vamsidhar , Meyyappan Jeyakumar , Yaccha Monika , Jain Manoj 
Published: June 2023

Abstract
Introduction: Steroid-resistant nephrotic syndrome (SRNS) children carry poor outcomes. In the hope of achieving remission, patients are frequently treated with repeated courses of steroids and other immunosuppressives. Patients with genetic mutations are usually steroid-resistant, except for a few patients. There is a paucity of data on genetic mutations in Indian children with SRNS. Methods: In this study, we identified SRNS patients and were asked for whole exome sequencing to identify mutations responsible for steroid resistance after informed consent from the parents or Guardians. We also analyzed the phenotypic and genotypic association with clinical course and response to varied immunosuppressive medications. Result: A total of 82 SRNS children included in the study were categorized into syndromic, in whom systemic features other than NS were also present; and non-syndromic SRNS do not have any other systemic features. Of the 82 patients subjected to genetic analysis, 29 did not reveal any mutations, and 53 showed genetic mutations. Genetic mutation variants were categorized according to ACMG criteria which showed 10 pathogenic, 5 likely pathogenic, and 38 variants of unknown significance. Mutations detected in SRNS children differed from those reported in the Western world. Nineteen of 82 SRNS children had Alport syndrome on mutational analysis. We identified many novel mutations associated with SNRS and also observed that many mutations were responsive to immunosuppression. Conclusions: The genetic analysis may obviate the need for a repeated course of immunosuppression with obvious mutations that are unlikely to respond to immunosuppression. Alport syndrome may present as SRNS in children.