bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disentangling the distal association between β-Amyloid and tau pathology at varying stages of tau deposition
Authors: Hojjati Seyed Hani , Chiang Gloria C. , Butler Tracy A. , De Leon Mony , Gupta Ajay , Li Yi , Sabuncu Mert R. , Feiz Farnia , Nayak Siddharth , Shteingart Jacob , Ozoria Sindy , Picha Saman Gholipour , Fernández Antonio , Stern Yaakov , Luchsinger José A. , Devanand Davangere P. , Razlighi Qolamreza R. 
Published: March 2023

AbstractStudies on the histopathology of Alzheimer’s disease (AD) strongly suggest that extracellular β-amyloid (Aβ) plaques promote the spread of neurofibrillary tau tangles. Despite well-documented spatial discrepancies between these two proteinopathies, their association remains elusive. In this study, we aimed to investigate the distal (non-local) association between tau and Aβ deposition by studying the Aβ, and tau positron emission tomography (PET) scans of 572 elderly subjects, aged 67.11 ± 6.08 years (476 healthy controls (HC), 14 with mild cognitive impairment (MCI), 82 mild AD). We also leveraged 47 tau-PET and 97 Aβ-PET scans of healthy young individuals (aged 20-40) to find regional cut-points for tau- and Aβ-positivity in 68 cortical regions in the brain. Based on these cut-points, we implemented a pseudo longitudinal technique to categorize the elderly subjects into four pathologic phases of AD progression: a no-tau phase, a pre-acceleration phase, an acceleration phase, and a post-acceleration phase. We then assessed the distal association between tau and Aβ in each phase using multiple linear regression models. First, we show that the association between tau and Aβ starts distally in medial temporal lobe (MTL) regions of tau (e.g., left and right entorhinal cortex and right parahippocampal gyrus) in the early stage of tau aggregation (pre-acceleration phase). We then show that tau in several bilateral brain regions (particularly the entorhinal cortex and parahippocampal gyrus) exhibits strong distal associations with Aβ in several cortical brain regions during the acceleration phase. We found a weak distal association in the post-acceleration phase, comprising 96% of MCI or mild AD and Aβ+ subjects. Most importantly, we show that the HC Aβ+ subjects have the highest degree of distal association between tau and Aβ of all the subjects in the acceleration phase. The results of this study characterize the distal association between the two key proteinopathies of AD. This information has potential use for understanding disease progression in the brain and for the development of anti-tau therapeutic agents.
Development of a significant index model for assessing heritage building maintenance management challenges
Authors: Adegoriola Mayowa I. , Lai Joseph H.K. , Yung Esther H.K. , Chan Edwin H.W. 
Published: March 2023

PurposeThe paper aims to identify the critical constraints that impede heritage building (HB) facility managers from discharging their duties effectively and develop an index model to guide HB maintenance management (HBMM) practitioners to the critical constraints.Design/methodology/approachA literature review was conducted to identify HBMM constraints. Facilty management practitioners assessed the constraints' significance through an online survey. The factor analysis was used to shortlist and group the constraints, and the constraint clusters were analyzed by the fuzzy synthetic evaluation technique. A significant index cluster to determine HBMM constraints criticality was generated using the linear additive model.FindingsEmbracing a total of 16 HBMM constraints, the three clusters identified are: (1) managerial and inadequacy constraints, (2) pressure and bureaucracy constraints and (3) HB peculiarities constraints. Based on the generated significant index, the HB peculiarities cluster was identified as the most significant.Research limitations/implicationsThe study was conducted in a particular jurisdiction, limiting the generalizability of the result. Future research should address this limitation by covering more jurisdictions.Practical implicationsThe significant index model (SIM) developed enables HBMM practitioners to objectively assess the criticality of HB constraints and facilitates them to effectively strategize and allocate resources for HBMM.Originality/valueThe SIM, which transforms subjective judgment into the objective assessment of the HBMM constraints' criticality, can assist practitioners, policymakers and other HBMM stakeholders in implementing strategies for the sustainability of HBs.
Bidding under uncertainty: Harsh Constructions
Authors: Iyer Sesha , Krishna Malay , Arora Sunny Vijay 
Published: March 2023

Learning outcomes
1. Probabilistic calculations of cost, and profit/loss using standard probability functions
2. Decision tree to find the expected monetary value (EMV) of different options.
3. Monte Carlo simulation for risk analysis.
4. Risk analysis in project management.

Learning objectives
Learners will be able to understand and apply the following: how to approach uncertainty in business decisions using probabilistic calculations of cost, and profit/loss using standard probability functions; how to address uncertainty in business decisions by looking forward and reasoning backward, using the decision tree technique and the EMV of different decisions; how to analyse the risk inherent in business decisions by incorporating probability distributions for all critical variables in the form of Monte Carlo simulation; and appreciation of strategic considerations in risk analysis as it applies to project management

Case overview/synopsis
The case describes the challenge facing Vilas Birari, the owner and chief executive of Harsh Constructions, a construction company headquartered in Nasik, India. Birari had to decide on the bid for a construction project in September of 2021, during the COVID-19 (COVID) pandemic. Due to successive waves of the pandemic, the state and federal governments announced lockdowns intermittently, causing uncertainty in costs related to labor, material and project completion. The dilemma before Birari was how to set a bid price that was not so low as to incur a loss and not so high as to lose the bid to competitors. The uncertainty made Birari’s decision-making complex. The case invites students to help Birari find an optimum bid price by using various quantitative techniques, such as Monte Carlo simulation and decision trees.

Complexity academic level
This case is intended for students of management at a master’s level, in an elective course on management science, which is often also known as decision science. This compact case can be positioned in the second half of the course, when exploring risk management using computer simulation as a tool. The case serves both as an introduction to using simulation to manage uncertainty as well a contrast with simpler methods that are covered earlier in the course.

Supplementary material
Teaching notes are available for educators only.

Subject code
CSS 7: Management Science.
The impact of oil prices, financial development and economic growth on renewable energy use
Authors: Deka Abraham , Özdeşer Hüseyin , Seraj Mehdi 
Published: March 2023

Purpose
The purpose of this study is to verify all factors that promote renewable energy (RE) consumption. Past studies have shown that financial development (FD) and economic growth (EG) are the major drivers toward RE development, while oil prices had mixed outcomes in different regions by different studies.

Design/methodology/approach
Global warming effects have been the major reason of the transition by nations from fossil fuel use to RE sources that are considered as friendly to the environment. This research uses the fixed effects and random effects techniques, to ascertain the factors which impact RE development. The generalized linear model is also used to check the robustness of the Fixed Effects and Random Effects models’ results, while the Kao, Pedroni and Westerlund tests are used to check cointegration in the specified model.

Findings
The major findings of this study show the importance of EG and FD in promoting RE development. Oil prices, inflation rate and public sector credit present a negative effect on RE development, while foreign direct investment does not significantly impact RE development.

Practical implications
This research recommends the use of FD in promoting RE sources, as well as the stabilization of oil prices and consumer prices.

Originality/value
This research is important because it specifies the three proxies of FD, together with foreign direct investment inflation rate, EG and oil prices, in modeling RE. By investigating the impact of oil prices on RE in the emerging seven economies, this research becomes one of the few studies done in this region, as per the authors’ knowhow.
The critical success factors for Security Education, Training and Awareness (SETA) program effectiveness: a lifecycle model
Authors: Alyami Areej , Sammon David , Neville Karen , Mahony Carolanne 
Published: March 2023

PurposeThis study explores the critical success factors (CSFs) for Security Education, Training and Awareness (SETA) program effectiveness. The questionable effectiveness of SETA programs at changing employee behavior and an absence of empirical studies on the CSFs for SETA program effectiveness is the key motivation for this study.Design/methodology/approachThis exploratory study follows a systematic inductive approach to concept development. The methodology adopts the “key informant” approach to give voice to practitioners with SETA program expertise. Data are gathered using semi-structured interviews with 20 key informants from various geographic locations including the Gulf nations, Middle East, USA, UK and Ireland.FindingsIn this study, the analysis of these key informant interviews, following an inductive open, axial and selective coding approach, produces 11 CSFs for SETA program effectiveness. These CSFs are mapped along the phases of a SETA program lifecycle (design, development, implementation and evaluation) and nine relationships identified between the CSFs (within and across the lifecycle phases) are highlighted. The CSFs and CSFs' relationships are visualized in a Lifecycle Model of CSFs for SETA program effectiveness.Originality/valueThis research advances the first comprehensive conceptualization of the CSFs for SETA program effectiveness. The Lifecycle Model of CSFs for SETA program effectiveness provides valuable insights into the process of introducing and sustaining an effective SETA program in practice. The Lifecycle Model contributes to both theory and practice and lays the foundation for future studies.
Big data ethics and its role in the innovation and technology adoption process
Authors: Bosman Lisa , Oladepo Taofeek , Ngambeki Ida 
Published: March 2023

PurposeUpon graduating from university, many engineers will work in new product development and/or technology adoption for continuous improvement and production optimization. These jobs require employees to be cognizant of ethical practices and implications for design. However, little engineering coursework, outside the traditional ABET (Accreditation Board for Engineering and Technology) required Engineering Ethics course, accounts for the role of ethics within this process. Because of this, engineering students have few learning opportunities to practice and reflect on ethical decision-making.Design/methodology/approachThis paper highlights one approach to integrating ethics into an engineering course (outside of engineering ethics). Specifically, the study is implemented within a five-week module with a focus on big data ethics, as part of a Supply Chain Management Technology course (required for Industrial Engineering Technology majors), using metacognition as the core assessment.FindingsFour main themes were identified through the qualitative data analysis of the metacognitive reflections: (1) overreliance on content knowledge, (2) time management skills, (3) career connections and (4) knowledge extensions.Originality/valueThree notable points emerged which contribute to the literature. First, this study showcased one example of how an ethics module can be integrated into an engineering course (other than Engineering Ethics). Second, this study demonstrated how metacognitive reflections can be used to reinforce student self-awareness of the learning process and connections to big data ethics in the workplace. Finally, this study exhibited how metacognitive reflection assignments can be deployed as a teaching and learning assessment tool, providing an opportunity for the instructor to make immediate changes as needed.
Network analysis of innovation mentor community of practice
Authors: Altinisik Gunda Esra , Aydin Mehmet Nafiz , Perdahci Ziya Nazim , Pasin Merih 
Published: March 2023

PurposePositive effect of knowledge sharing (KS) on innovation has come to the fore and government-supported innovation and mentoring communities or mentor networks have become widespread. This article aims to examine the community connectedness and mentors' preferences for professional competency-based KS of such innovation community of practice networks (CoPNs).Design/methodology/approachThe paper constructs a directed weighted CoPN model with a node-attribute-based novel fingerprint edge weights. Based on the CoPN, Social Network Analysis (SNA) metrics and measures including Giant Component (GC) were proposed and analyzed to identify mentors' connectedness preferences. The fingerprint was proposed as a novel binarized node attribute of competence. Jaccard similarity of fingerprints was proposed as edge weights to reveal correlations between competences and preferences for KS.FindingsThe work opted to conduct a survey of 28 innovation mentors to measure a CoPN. Both a name generator question and a second set of questions were employed to invite respondents to name their collaborators and indicate their professional competence. SNA metrics result in differing values for GC and the rest, which lead us to focus on GC to reveal salient metrics of connectedness. Jaccard similarity analysis results on GC demonstrate that mentors collaborate in an interdisciplinary manner.Originality/valueBased on the CoPN, the methods proposed may be effective in predicting preferred relationships for interdisciplinary collaborations, providing the managers with an analytical decision support tool for KS in practice.
The benefits for European companies and investors of promoting happiness through high-performing work policies
Authors: De la Torre-Torres Oscar Valdemar , Martínez Torre-Enciso María Isabel , Del Río-Rama María de la Cruz , Álvarez-García José 
Published: March 2023

PurposeIn this paper, the authors tested if promoting the workforce's happiness (through high performance work policies or HPWP) and well-being in European Public companies relates to their profitability (return on equity, ROE), market risk (beta) and stock price return. Also, the authors tested if investors have a performance benefit if they buy a portfolio screened with companies with HPWP.Design/methodology/approachThe authors proxied the quality of the HPWP efforts in the first method with the Refinitiv workforce score. They used this data in an unbalanced panel of eastern, western, northern and southern Europe companies from 2011 to 2022. The panel data also included the ROE, the market risk (beta) and the stock price return of these companies. The authors estimated the corresponding regressions with the panel data and tested the relationship between the workforce score and these three variables. In a second method, they simulated the weekly performance of a portfolio that invested only in European companies with high standards in their HPWP and compared its performance against a conventional market portfolio (with no HPWP screening).FindingsIn the first method, the authors found no significant relationship between the workforce score and the ROE, beta, or stock price return in the panel regression, controlling for random effects. In the second one, they found no over or underperformance in the HPWP portfolio against the European market one in the second method.Practical implicationsThe results suggest that there is no risk or cost for European Public companies and investors alike if they promote, with better HPWP, the happiness and well-being of their workforce. The findings suggest that if European companies promote HPWP, there will be no adverse impact on their profits, market risk, or stock price performance. Also, investors will not lose performance (against a conventional market portfolio) if they screen their portfolios with this type of workforce-friendly companies.Originality/valueIncrease the scarce literature on the test of the workforce score with company profitability (ROE), stock market price variation and stock market risk level.
Response of habitat quality to mixed severity disturbance regime in Norway spruce forests
Authors: Bace Radek , Hofmeister Jenyk , Vitkova Lucie , Brabec Marek , Begovic Kresimir , Cada Vojtech , Janda Pavel , Kozak Daniel , Mikolas Martin , Nagel Thomas A. , Pavlin Jakob , Rodrigo Ruffy , Vostarek Ondrej , Svoboda Miroslav 
Published: March 2023

AbstractNatural disturbances change forest habitat quality for many species. As the extent and intensity of natural disturbances may increase under climate change, it is unclear how this increase can affect habitat quality on different spatial scales. To support management tools and policies aiming to prevent habitat loss, we studied how habitat quality develops in the long run depending on the disturbance severity using a space‐for‐time substitution approach.We explored the effects of time since disturbance (0–250 years) and disturbance severity (20%–100% canopy removal) on structure‐based habitat quality indicators in European primary Norway sprucePicea abiesforests using 1000 m2circular plots in hierarchical design (a total of 407 plots in 35 stands). Disturbance history was reconstructed from tree cores. Habitat quality indicators were modelled as a function of the severity of the most severe disturbance and the time since this disturbance. We hypothesised that high within‐stand habitat heterogeneity is formed by different successional stages after disturbances of various intensities.The results showed a U‐shaped response of habitat quality to post‐disturbance habitat succession on the plot scale. The decline deepened with disturbance severity. The U‐shape response occurred in: large tree occurrence, amount of standing and lying deadwood, diversity of understory and understory openness. The spatial diversity in disturbance parameters increased spatial diversity of habitat quality on a stand level as expected. This high within‐stand habitat heterogeneity also decreased with increasing age of the most recent disturbance. This suggests that the absence of young successional stages results in the absence of some important elements for biodiversity, for example sun‐exposed snags.Synthesis and applications.Our results demonstrate that currently intensifying natural disturbance regime can consequently result in a lower habitat heterogeneity. In managed spruce forests after natural disturbances, we recommend at least the partial retention of biological legacies to preserve habitat heterogeneity and to avoid uniform and dense plantations resulting in a greater homogenisation. To emulate the natural disturbances pattern, spruce forests should be managed with a wide range of harvested patches of the size limited by a local natural disturbance regime creating spatial heterogeneity.
Hearts in their hands—Physicians’ gestures embodying shared professional knowledge around the world
Authors: Quasinowski Benjamin , Assa Solmaz , Bachmann Cadja , Chen Wei , Elcin Melih , Kamisli Caner , Liu Tao , Maass Alexander H. , Merse Stefanie , Morbach Caroline , Neumann Anja , Neumann Till , Sommer Ilka , Stoerk Stefan , Weingartz Sarah , Weiss Anja , Wietasch Goetz 
Published: March 2023

AbstractThe biomedical approach to medical knowledge is widely accepted around the world. This article considers whether the incorporated aspects of physician‐patient interaction have become similarly common across the globe by comparing the gestures that physicians use in their interactions with patients. Up to this point, there has been little research on physicians’ use of gestures in health‐care settings. We explore how—in four university hospitals in Turkey, the People’s Republic of China, The Netherlands and Germany—physicians use gesture in their discussions with simulated patients about the condition of heart failure. Our analysis confirms the importance of gestures for organising both the personal interaction and the knowledge transfer between physician and patient. From the perspective of global comparison, it is notable that physicians in all four hospitals used similar gestures. This demonstrates the globality of biomedical knowledge in an embodied mode. Physicians used gestures for a range of purposes, including to convey the idea of an ‘anatomical map’ and for constructing visual models of (patho‐)physiological processes. Since biomedical language is rife with metaphor, it was not surprising that we also identified an accompanying metaphorical gesture which has a similar form in the various locations that were part of the study.
Target‐capture probes for phylogenomics of the Caenogastropoda
Authors: Goulding Tricia C. , Strong Ellen E. , Quattrini Andrea M. 
Published: March 2023

AbstractTarget‐capture approaches have facilitated a rapid growth in the field of phylogenomics but few probe sets exist for molluscs, an exceptionally rich phylum with unparalleled ecological and morphological diversity. We designed and tested the first universal probe set using Phyluce to capture ultraconserved elements (UCEs) and exon loci from the Subclass Caenogastropoda ‐ one of six major lineages of gastropods. The probe set consists of 29,441 probes designed to target 1142 UCE loci and 1933 exon loci (3075 total). In silico analyses of our probe set yielded an average of 2110 loci from genomes and 1389 loci from transcriptomes of diverse caenogastropods, from which an average of 1669 and 849 loci were retained respectively after screening to remove those that matched multiple contigs. Phylogenetic analyses of the loci extracted from transcriptomes produced well‐supported trees very similar to those published based on transcriptomic analyses. Phylogenetic relationships estimated from loci extracted from genomes recover similar phylogenetic relationships, and indicate that the loci targeted with this probe set are informative for resolving deep phylogenetic relationships. An in vitro analysis of the probe set with the Epitoniidae, a diverse caenogastropod family of uncertain affinity and with poorly resolved evolutionary relationships, recovered a total of 2850 loci. Although preliminary, the analysis of loci captured by our probe set for a small number of epitoniid taxa produced a well‐resolved tree indicating that this probe set is also able to resolve relationships at shallower hierarchical scales. Together, the in silico and in vitro analyses indicate that target‐capture enrichment with this probe set is a useful tool for reconstructing phylogenetic relationships across taxonomic levels and evolutionary time scales.