bluuebunny/crossref_metadata_2025_split huggingface dataset:
A leadership model supporting maturation of high-performance translational teams
Authors: Brasier Allan R. , Casey Shannon L. , Hatfield Peggy , Kelly Patrick W. , Sweeney Whitney A. , Schweizer Marin , Liu Bo , Burnside Elizabeth S. 
Published: July 2023

AbstractDespite understanding its impact on organizational effectiveness, practical guidance on how to train translational team (TT) leaders is lacking. Previously, we developed an evolutionary learning model of TT maturation consisting of three goal-directed phases: (1). team assembly (Formation); (2). conducting research (Knowledge Generation); and (3). dissemination and implementation (Translation). At each phase, the team acquires group-level knowledge, skills, and attitudes (KSAs) that enhance its performance. Noting that the majority of team-emergent KSAs are promoted by leadership behaviors, we examine the SciTS literature to identify the relevant behaviors for each phase. We propose that effective team leadership evolves from a hierarchical, transformational model early in teamFormationto a shared, functional leadership model duringTranslation. We synthesized an integrated model of TT leadership, mapping a generic “functional leadership” taxonomy to relevant leadership behaviors linked to TT performance, creating an evidence-informed Leadership and Skills Enhancement for Research (LASER) training program. Empirical studies indicate that leadership behaviors are stable across time; to enhance leadership skills, ongoing reflection, evaluation, and practice are needed. We provide a comprehensive multi-level evaluation framework for tracking the growth of TT leadership skills. This work provides a framework for assessing and training relevant leadership behaviors for high-performance TTs.
COFINAL TYPES BELOW
Authors: SHALEV ROY 
Published: July 2023

Abstract
It is proved that for every positive integer n, the number of non-Tukey-equivalent directed sets of cardinality

$\leq \aleph _n$

is at least

$c_{n+2}$

, the

$(n+2)$

-Catalan number. Moreover, the class

$\mathcal D_{\aleph _n}$

of directed sets of cardinality

$\leq \aleph _n$

contains an isomorphic copy of the poset of Dyck

$(n+2)$

-paths. Furthermore, we give a complete description whether two successive elements in the copy contain another directed set in between or not.
A DOUBLE TRAGIC ALLUSION IN AMMIANUS MARCELLINUS 14.1.3
Authors: Alonso Francisco J. 
Published: July 2023

AbstractThis article identifies a double allusion to the tragic characters of Phaedra and Eriphyle in Amm. Marc. 14.1.3 and considers its possible meanings. In combination, these allusions evoke the double nature of the story of Eriphyle, therefore functioning as a reference to the double nature of Caesar Gallus’ depiction in Ammianus. The double allusion consequently forms part of Ammianus’ tragic style throughout Book 14. Having identified the presence of this double allusion, the article illuminates its possible meaning by connecting Ammianus’ passage to the Virgilian rewriting of the description of Eriphyle in Homer.
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Authors: Morand-Beaulieu Simon , Crowley Michael J. , Grantz Heidi , Leckman James F. , Sukhodolsky Denis G. 
Published: July 2023

AbstractBackgroundComprehensive Behavioral Intervention for Tics (CBIT) is recommended as a first-line treatment for Tourette syndrome in children and adults. While there is strong evidence proving its efficacy, the mechanisms of reduction in tic severity during CBIT are still poorly understood. In a recent study, our group identified a functional brain network involved in tic suppression in children with TS. We reasoned that voluntary tic suppression and CBIT may share some mechanisms and thus we wanted to assess whether functional connectivity during tic suppression was associated with CBIT outcome.MethodsThirty-two children with TS, aged 8 to 13 years old, participated in a randomized controlled trial of CBIT v. a treatment-as-usual control condition. EEG was recorded during tic suppression in all participants at baseline and endpoint. We used a source-reconstructed EEG connectivity pipeline to assess functional connectivity during tic suppression.ResultsFunctional connectivity during tic suppression did not change from baseline to endpoint. However, baseline tic suppression-related functional connectivity specifically predicted the decrease in vocal tic severity from baseline to endpoint in the CBIT group. Supplementary analyses revealed that the functional connectivity between the right superior frontal gyrus and the right angular gyrus was mainly driving this effect.ConclusionsThis study revealed that functional connectivity during tic suppression at baseline predicted reduction in vocal tic severity. These results suggest probable overlap between the mechanisms of voluntary tic suppression and those of behavior therapy for tics.
On the maximum number of edges in -critical graphs
Authors: Luo Cong , Ma Jie , Yang Tianchi 
Published: July 2023

AbstractA graph is called
$k$
-critical if its chromatic number is
$k$
but every proper subgraph has chromatic number less than
$k$
. An old and important problem in graph theory asks to determine the maximum number of edges in an
$n$
-vertex
$k$
-critical graph. This is widely open for every integer
$k\geq 4$
. Using a structural characterisation of Greenwell and Lovász and an extremal result of Simonovits, Stiebitz proved in 1987 that for
$k\geq 4$
and sufficiently large
$n$
, this maximum number is less than the number of edges in the
$n$
-vertex balanced complete
$(k-2)$
-partite graph. In this paper, we obtain the first improvement in the above result in the past 35 years. Our proofs combine arguments from extremal graph theory as well as some structural analysis. A key lemma we use indicates a partial structure in dense
$k$
-critical graphs, which may be of independent interest.
Factors Associated with Symptom-to-Door Delay in Patients with ST-Segment Myocardial Infarction: A Systematic Review
Authors: Lu Xiuyan , Xia Wei , Wang Xinru , Xie Fangyu , Sun Xiujie 
Published: July 2023

AbstractBackground:Decreasing symptom-to-door (S2D) delay is of vital importance for reducing morbidity and mortality in patients with ST-segment elevation myocardial infarction (STEMI). The factors associated with S2D delay in STEMI patients have not been well-characterized.Objectives:The aim of this study was to identify factors associated with S2D delay in patients with STEMI.Methods:The PubMed, CINAHL, and Embase databases were searched for data. References from the selected articles and relevant background papers were also manually searched to identify additional eligible studies. The included articles were reviewed and assessed for risk of bias. The level of evidence for each identified factor was evaluated using a semiquantitative synthesis.Results:Twelve (12) papers were included in the review. Factors associated with S2D delay were complex and could be divided into sociodemographic, clinical history, and onset characteristics. The level of evidence regarding female sex and diabetes was strong, and the evidence was moderate regarding older age, smoking, history of hypertension, self-transport, or referral.Conclusions:Female sex, older age, previous diabetes, previous hypertension, smoking, and self-transport are all strong or moderate risk factors for S2D time delay in patients with ST-segment myocardial infarction. More efforts should be made to educate at-risk populations concerning symptoms of STEMI and the importance of seeking early medical assistance.
An Improved Satellite‐Based Evapotranspiration Procedure for China
Authors: Huang Lei , Luo Yong , Steenhuis Tammo , Tang Qiuhong , Cheng Wei , Shi Wen , Xia Xin , Zhao Dingchi , Liao Zhouyi 
Published: July 2023

AbstractEvapotranspiration (ET) is a critical process that regulates the transfer of heat and water between land and the atmosphere. While satellite‐based ET algorithms can provide area‐wide daily ET estimates, few are independent of local meteorological measurements. The Variant of the Moderate Resolution Imaging Spectroradiometer Standard Evapotranspiration Algorithm (VISEA) can potentially run without ground‐based observations. However, the surface energy budgets used in VISEA generally overpredict daily net radiation and related ET. To improve the accuracy of net radiation and ET, we incorporated Brutsaert's atmosphere emissivity model and corrected the routine to calculate the downward long‐wave radiation on cloudy days (which we called VISEA2023 model). The VISEA2023 model predicted net radiation and ET that agreed well with measurements at seven ChinaFlux sites, with an R2 of 0.8 and an Root Mean Square Error (RMSE) of 30 W m−2 for net radiation, and an R2 of 0.6 and an RMSE of 1 mm day−1 for ET, respectively. Additionally, the VISEA2023 model is more robust in comparison to the Variable Infiltration Capacity hydrologic model output in 10 major river basins and 80 sub‐river basins, with an R2 of 0.91 (0.78) and an RMSE of 85 (127.4) mm year−1, than MOD16, which has an R2 of 0.81 (0.82) and an RMSE of 134.8 (157.7) mm year−1, and Advanced Very High Resolution Radiometer ET, which has an R2 of 0.92 (0.62) and an RMSE of 90.1 (136.1) mm year−1. The improved VISEA2023 model can offer near‐real‐time ET on a larger scale, improving our understanding of water cycles and their relation to climate change.
Spectral Analysis of Ionospheric Density Variations Measured With the Large Radio Telescope in the Low‐Latitude Region
Authors: Mangla Sarvesh , Datta Abhirup 
Published: July 2023

AbstractThe low‐latitude ionosphere is a dynamic region with a wide range of disturbances in temporal and spatial scales. The Giant Metrewave Radio Telescope (GMRT) situated in the low‐latitude region has demonstrated its ability to detect various ionospheric phenomena. It can detect total electron content (TEC) variation with precision of 10−3 TECU and also can measure TEC gradient with an accuracy of about 7 × 10−4 TECU km−1. This paper describes the spectral analysis of previously calculated TEC gradient measurements and validates them by comparing their properties using two bands. The analysis tracked individual waves associated with medium‐scale traveling ionospheric disturbances (MSTIDs) and smaller waves down to wavelengths of ∼10 km. The ionosphere is found to have unanticipated changes during sunrise hours, with waves changed propagation direction as the sun approached the zenith. Equatorial spread F disturbances during sunrise hours is observed, along with smaller structures moving in the same direction.
Streamlined and on-demand preparation of mRNA products on a universal integrated platform
Authors: Wei Hongjuan , Rong Zhen , Liu Liyan , Sang Ye , Yang Jing , Wang Shengqi 
Published: July 2023

AbstractVaccines are used to protect human beings from various diseases. mRNA vaccines simplify the development process and reduce the production cost of conventional vaccines, making it possible to respond rapidly to acute and severe diseases, such as coronavirus disease 2019. In this study, a universal integrated platform for the streamlined and on-demand preparation of mRNA products directly from DNA templates was established. Target DNA templates were amplified in vitro by a polymerase chain reaction module and transcribed into mRNA sequences, which were magnetically purified and encapsulated in lipid nanoparticles. As an initial example, enhanced green fluorescent protein (eGFP) was used to test the platform. The expression capacity and efficiency of the products were evaluated by transfecting them into HEK-293T cells. The batch production rate was estimated to be 200–300 μg of eGFP mRNA in 8 h. Furthermore, an mRNA vaccine encoding the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein was produced by this platform. The proposed integrated platform shows advantages for the universal and on-demand preparation of mRNA products, offering the potential to facilitate broad access to mRNA technology and enable the development of mRNA products, including the rapid supply of new mRNA-based vaccines in pandemic situations and personalized mRNA-based therapies for oncology and chronic infectious diseases, such as viral hepatitis and acquired immune deficiency syndrome.
μeV electron spectromicroscopy using free-space light
Authors: Auad Yves , Dias Eduardo J. C. , Tencé Marcel , Blazit Jean-Denis , Li Xiaoyan , Zagonel Luiz Fernando , Stéphan Odile , Tizei Luiz H. G. , García de Abajo F. Javier , Kociak Mathieu 
Published: July 2023

AbstractThe synergy between free electrons and light has recently been leveraged to reach an impressive degree of simultaneous spatial and spectral resolution, enabling applications in microscopy and quantum optics. However, the required combination of electron optics and light injection into the spectrally narrow modes of arbitrary specimens remains a challenge. Here, we demonstrate microelectronvolt spectral resolution with a sub-nanometer probe of photonic modes with quality factors as high as 104. We rely on mode matching of a tightly focused laser beam to whispering gallery modes to achieve a 108-fold increase in light-electron coupling efficiency. By adapting the shape and size of free-space optical beams to address specific physical questions, our approach allows us to interrogate any type of photonic structure with unprecedented spectral and spatial detail.
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib
Authors: Coombes R. C. , Howell Sacha , Lord Simon R. , Kenny Laura , Mansi Janine , Mitri Zahi , Palmieri Carlo , Chap Linnea I. , Richards Paul , Gradishar William , Sardesai Sagar , Melear Jason , O’Shaughnessy Joyce , Ward Patrick , Chalasani Pavani , Arkenau Tobias , Baird Richard D. , Jeselsohn Rinath , Ali Simak , Clack Glen , Bahl Ashwani , McIntosh Stuart , Krebs Matthew G. 
Published: July 2023

AbstractSamuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with advanced malignancies was designed (ClinicalTrials.gov: NCT03363893). Here we report results from dose escalation and 2 expansion cohorts: Module 1A dose escalation with paired biopsy cohort in advanced solid tumor patients, Module 1B-1 triple negative breast cancer (TNBC) monotherapy expansion, and Module 2A fulvestrant combination in HR+/HER2− breast cancer patients post-CDK4/6-inhibitor. Core study primary endpoints are safety and tolerability, and secondary endpoints are pharmacokinetics (PK), pharmacodynamic (PD) activity, and anti-tumor activity. Common adverse events are low grade nausea, vomiting, and diarrhea. Maximum tolerated dose is 360 mg once daily. PK demonstrates dose proportionality (120 mg-480 mg), a half-life of approximately 75 hours, and no fulvestrant interaction. In dose escalation, one partial response (PR) is identified with disease control rate of 53% (19/36) and reduction of phosphorylated RNA polymerase II, a substrate of CDK7, in circulating lymphocytes and tumor tissue. In TNBC expansion, one PR (duration 337 days) and clinical benefit rate at 24 weeks (CBR) of 20.0% (4/20) is achieved. In combination with fulvestrant, 3 patients achieve PR with CBR 36.0% (9/25); in patients without detectable TP53-mutation CBR is 47.4% (9/19). In this study, samuraciclib exhibits tolerable safety and PK is supportive of once-daily oral administration. Clinical activity in TNBC and HR+/HER2-breast cancer post-CDK4/6-inhibitor settings warrants further evaluation.
Effects of oxidative stress on hepatic encephalopathy pathogenesis in mice
Authors: Bai Yunhu , Li Kenan , Li Xiaodong , Chen Xiyu , Zheng Jie , Wu Feifei , Chen Jinghao , Li Ze , Zhang Shuai , Wu Kun , Chen Yong , Wang Yayun , Yang Yanling 
Published: July 2023

AbstractOxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but the mechanism remains unclear. GABAergic neurons in substantia nigra pars reticulata (SNr) contribute to the motor deficit of HE. The present study aims to investigate the effects of oxidative stress on HE in male mice. The results validate the existence of oxidative stress in both liver and SNr across two murine models of HE induced by thioacetamide (TAA) and bile duct ligation (BDL). Systemic mitochondria-targeted antioxidative drug mitoquinone (Mito-Q) rescues mitochondrial dysfunction and oxidative injury in SNr, so as to restore the locomotor impairment in TAA and BDL mice. Furthermore, the GAD2-expressing SNr population (SNrGAD2) is activated by HE. Both overexpression of mitochondrial uncoupling protein 2 (UCP2) targeted to SNrGAD2 and SNrGAD2-targeted chemogenetic inhibition targeted to SNrGAD2 rescue mitochondrial dysfunction in TAA-induced HE. These results define the key role of oxidative stress in the pathogenesis of HE.
ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins
Authors: Mas Aina Maria , Goñi Enrique , Ruiz de los Mozos Igor , Arcas Aida , Statello Luisa , González Jovanna , Blázquez Lorea , Lee Wei Ting Chelsea , Gupta Dipika , Sejas Álvaro , Hoshina Shoko , Armaos Alexandros , Tartaglia Gian Gaetano , Waga Shou , Ule Jernej , Rothenberg Eli , Gómez María , Huarte Maite 
Published: July 2023

AbstractCells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA plays in this process remains unclear. We show that the ORC1 subunit of the human Origin Recognition Complex interacts with RNAs transcribed from genes with origins in their transcription start sites (TSSs), displaying a positive correlation between RNA binding and origin activity. RNA depletion, or the use of ORC1 RNA-binding mutant, result in inefficient activation of proximal origins, linked to impaired ORC1 chromatin release. ORC1 RNA binding activity resides in its intrinsically disordered region, involved in intra- and inter-molecular interactions, regulation by phosphorylation, and phase-separation. We show that RNA binding favors ORC1 chromatin release, by regulating its phosphorylation and subsequent degradation. Our results unveil a non-coding function of RNA as a dynamic component of the chromatin, orchestrating the activation of replication origins.
Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection
Authors: Slough Megan M. , Li Rong , Herbert Andrew S. , Lasso Gorka , Kuehne Ana I. , Monticelli Stephanie R. , Bakken Russell R. , Liu Yanan , Ghosh Agnidipta , Moreau Alicia M. , Zeng Xiankun , Rey Félix A. , Guardado-Calvo Pablo , Almo Steven C. , Dye John M. , Jangra Rohit K. , Wang Zhongde , Chandran Kartik 
Published: July 2023

AbstractAndes virus (ANDV) and Sin Nombre virus (SNV) are the etiologic agents of severe hantavirus cardiopulmonary syndrome (HCPS) in the Americas for which no FDA-approved countermeasures are available. Protocadherin-1 (PCDH1), a cadherin-superfamily protein recently identified as a critical host factor for ANDV and SNV, represents a new antiviral target; however, its precise role remains to be elucidated. Here, we use computational and experimental approaches to delineate the binding surface of the hantavirus glycoprotein complex on PCDH1’s first extracellular cadherin repeat domain. Strikingly, a single amino acid residue in this PCDH1 surface influences the host species-specificity of SNV glycoprotein-PCDH1 interaction and cell entry. Mutation of this and a neighboring residue substantially protects Syrian hamsters from pulmonary disease and death caused by ANDV. We conclude that PCDH1 is a bona fide entry receptor for ANDV and SNV whose direct interaction with hantavirus glycoproteins could be targeted to develop new interventions against HCPS.
An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats
Authors: Lin Sien , Maekawa Hirotsugu , Moeinzadeh Seyedsina , Lui Elaine , Alizadeh Hossein Vahid , Li Jiannan , Kim Sungwoo , Poland Michael , Gadomski Benjamin C. , Easley Jeremiah T. , Young Jeffrey , Gardner Michael , Mohler David , Maloney William J. , Yang Yunzhi Peter 
Published: July 2023

AbstractBone transport is a surgery-driven procedure for the treatment of large bone defects. However, challenging complications include prolonged consolidation, docking site nonunion and pin tract infection. Here, we develop an osteoinductive and biodegradable intramedullary implant by a hybrid tissue engineering construct technique to enable sustained delivery of bone morphogenetic protein-2 as an adjunctive therapy. In a male rat bone transport model, the eluting bone morphogenetic protein-2 from the implants accelerates bone formation and remodeling, leading to early bony fusion as shown by imaging, mechanical testing, histological analysis, and microarray assays. Moreover, no pin tract infection but tight osseointegration are observed. In contrast, conventional treatments show higher proportion of docking site nonunion and pin tract infection. The findings of this study demonstrate that the novel intramedullary implant holds great promise for advancing bone transport techniques by promoting bone regeneration and reducing complications in the treatment of bone defects.
The OsSGS3-tasiRNA-OsARF3 module orchestrates abiotic-biotic stress response trade-off in rice
Authors: Gu Xueting , Si Fuyan , Feng Zhengxiang , Li Shunjie , Liang Di , Yang Pei , Yang Chao , Yan Bin , Tang Jun , Yang Yu , Li Tai , Li Lin , Zhou Jinling , Li Ji , Feng Lili , Liu Ji-Yun , Yang Yuanzhu , Deng Yiwen , Wu Xu Na , Zhao Zhigang , Wan Jianmin , Cao Xiaofeng , Song Xianwei , He Zuhua , Liu Junzhong 
Published: July 2023

AbstractRecurrent heat stress and pathogen invasion seriously threaten crop production, and abiotic stress often antagonizes biotic stress response against pathogens. However, the molecular mechanisms of trade-offs between thermotolerance and defense remain obscure. Here, we identify a rice thermo-sensitive mutant that displays a defect in floret development under high temperature with a mutation in SUPPRESSOR OF GENE SILENCING 3a(OsSGS3a). OsSGS3a interacts with its homolog OsSGS3b and modulates the biogenesis oftrans-acting small interfering RNA (tasiRNA) targetingAUXIN RESPONSE FACTORS(ARFs). We find that OsSGS3a/b positively, while OsARF3a/b and OsARF3la/lb negatively modulate thermotolerance. Moreover, OsSGS3a negatively, while OsARF3a/b and OsARF3la/lb positively regulate disease resistance to the bacterial pathogenXanthomonas oryzaepv.oryzae(Xoo) and the fungal pathogenMagnaporthe oryzae(M. oryzae). Taken together, our study uncovers a previously unknown trade-off mechanism that regulates distinct immunity and thermotolerance through the OsSGS3-tasiRNA-OsARF3 module, highlighting the regulation of abiotic-biotic stress response trade-off in plants.