bluuebunny/crossref_metadata_2025_split huggingface dataset:
How can people benefit, and who benefits most, from using socialisation‐oriented social media at work? An affordance perspective
Authors: Wang Bin , Liu Yukun , Qian Jing , Parker Sharon K. 
Published: April 2023

AbstractPast research has predominantly regarded (private) socialisation‐oriented social media (SoSM) use at work as a counterproductive behaviour and has thus focussed more on its dark side. However, given the prevalence of social media in today's work life and the various affordances this technology can have, social media might have important bright sides. In this research, drawing on the affordance perspective, we propose that the day‐to‐day use of SoSM at work is positively associated with perceptions of social connectedness, which is further positively associated with life satisfaction and task performance. We examined our hypotheses using an experience sampling study of 134 full‐time employees in China across 10 consecutive workdays. The results of multilevel modelling showed that, as expected, daily SoSM use at work related positively with employees' perceptions of social connectedness, which in turn predicted their daily life satisfaction and daily task performance. We also found that the relationship between daily SoSM use at work and perceived social connectedness was stronger for employees with higher, rather than lower, perceived workloads. We suggest this moderating effect occurs because social media is an efficient medium, providing greater affordances, through which busy workers can meet their belongingness needs. Overall, our study sheds light on the previously less‐studied positive effects of social media use at work.
The effect of sperm DNA fragmentation on ICSI outcomes depending on oocyte quality
Authors: Braga Daniela Paes Almeida Ferreira , Setti Amanda , Morishima Christina , Provenza Rodrigo R. , Iaconelli Assumpto , Borges Edson 
Published: April 2023

AbstractBackgroundSperm deoxyribonucleic acid (DNA) fragmentation is commonly encountered in spermatozoa, and the oocyte assumes responsibility for repairing sperm DNA fragmentation during the oocyte–embryo transition.ObjectivesThis study aimed to investigate whether the effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcomes depends on the incidence of oocyte dimorphisms.Materials and methodsFor the present cohort, 2942 fertilized oocytes from 525 patients submitted to intracytoplasmic sperm injection cycles were assessed. The present study was conducted in a private in vitro fertilization center affiliated to a university from June 2016 to July 2019. Semen samples were divided into the following two groups depending on the sperm DNA fragmentation index: a low fragmentation index group (<30% sperm DNA fragmentation, n = 1468) and a high fragmentation index group (≥30% sperm DNA fragmentation, n = 486). In addition, mature oocytes were examined before sperm injection, and intracytoplasmic and extracytoplasmic defects were recorded. The effect of the sperm DNA fragmentation index on laboratory and clinical intracytoplasmic sperm injection outcomes (depending on the presence of oocyte defects) was evaluated.ResultsSignificant increases in the rates of fertilization, high‐quality embryo, implantation, and pregnancy were noted for cycles with <30% sperm DNA fragmentation than cycles with ≥30% sperm DNA fragmentation (regardless of the presence of oocyte dimorphisms). The presence of dimorphisms significantly impacted laboratory and clinical outcomes. The lowest fertilization and high‐quality embryo rates were observed when a high sperm DNA fragmentation index was associated with the presence of dark cytoplasm, vacuoles, resistant membrane, and non‐resistant membrane. The lowest implantation and pregnancy rates were observed when a high sperm DNA fragmentation index was associated with the presence of vacuoles, defective perivitelline space, and fragmented polar body. The effect of sperm DNA fragmentation on miscarriage rates was significantly influenced by the presence of centrally located cytoplasmic granulation, a defective perivitelline space and non‐resistant membrane.ConclusionA high sperm DNA fragmentation index increases the likelihood of miscarriage in intracytoplasmic sperm injection cycles, an effect that may potentially be magnified by the presence of oocyte dysmorphisms.
Efficacy and safety of nilotinib in chronic myeloid leukaemia patients who failed to achieve a treatment‐free remission period after imatinib discontinuation: Results of the French Nilo post‐STIM study
Authors: Dulucq Stéphanie , Rigal‐Huguet Françoise , Nicolini Franck E. , Cony‐Makhoul Pascale , Escoffre‐Barbe Martine , Gardembas Martine , Legros Laurence , Rousselot Philippe , Liu Jixing , Rea Delphine , De Mas Véronique , Hayette Sandrine , Raynaud Sophie , Lacoste‐Roussillon Caroline , Robbesyn Fanny , Klein Emilie , Morisset Stéphane , Mahon François‐Xavier , Etienne Gabriel 
Published: April 2023

SummaryMolecular recurrence (MRec) occurs in about half of all patients with chronic myeloid leukaemia (CML) who discontinue tyrosine kinase inhibitors (TKI) in sustained deep molecular response. A second TKI discontinuation has been attempted in some patients who regain the discontinuation criteria after resuming treatment. Nilotinib treatment affords faster and deeper molecular responses than imatinib as first‐line therapy. We prospectively evaluated the efficacy and safety of nilotinib (300 mg twice daily) in chronic‐phase CML patients who experienced MRec, after imatinib discontinuation and analysed the probability of TFR after a new attempt in patients treated for 2 years with sustained MR4.5 for at least 1 year. A total of 31 patients were included in the study between 2013 and 2018. Seven (23%) patients experienced serious adverse events after a median of 2 months of nilotinib treatment leading to discontinuation of treatment. One patient was excluded from the study for convenience. Among the 23 patients treated for 2 years with nilotinib, 22 maintained their molecular response for at least 1 year (median: 22 months) and stopped nilotinib. The TFR rates at 24 and 48 months after nilotinib discontinuation were 59.1% (95% confidence interval [CI]: 41.7%–83.7%) and 42.1% (95% CI: 25%–71%) respectively (NCT #01774630).
Impacts of climate change on the distribution of riverine endemic fish species in Iran, a biodiversity hotspot region
Authors: Makki Toktam , Mostafavi Hossein , Matkan Ali Akbar , Aghighi Hossein , Valavi Roozbeh , Chee Yung En , Teimori Azad 
Published: April 2023

Abstract

Iran is one of the world's fish biodiversity hotspots. Most riverine fish species in this country are currently under threat by human activities. In addition to those threats, climate change is expected to alter rainfall and temperature regimes, imposing further limitations, particularly to endemic fishes. Therefore, understanding how these species respond to climate change is an important issue in the conservation of Iranian freshwater biodiversity.

This study aimed to predict the potential distribution of 16 endemic fish species under two climate change scenarios (i.e., RCP 4.5 and RCP 8.5) in river habitats of Iran in the 2050s and the 2080s. The analysis is conducted using the MaxEnt model. Seven environmental variables were used for modelling: maximum width, elevation, river slope, the basins occupied by the target species, average annual precipitation, annual mean temperature, and the temperature difference between the coldest and hottest months of the year .

The validation of the model for each species showed that AUC (area under the ROC curve) scores range from 0.87 to 0.99. Under optimistic (RCP 4.5) and pessimistic (RCP 8.5) scenarios in the 2050s and the 2080s, species will face four different outcomes to their habitat range: reduction (three species), expansion (five species), reduction and expansion (seven species) and no change (one species).

It is concluded that most species that are unique in their geographical area will face serious challenges from climate change. Delineating species range changes under climate change scenarios can help prioritise conservation measures for these valuable species. Considering our results, the translocation of species to new locations also should be investigated.
The synergistic effect of texture and surface roughness on electrophoretic deposited bioactive glass coating
Authors: Yazdani Samani Fahimeh , Rabiee Sayed Mahmood , Jamaati Roohollah , Bagherifard Sara 
Published: April 2023

AbstractTo improve the biocompatibility of AISI 316L, bioactive glass (BG) coating of SiO2–CaO–P2O5 which helps bonding with bone implants was used by an electrophoretic deposition method. Before coating deposition, the samples were treated by shot peening, known as an efficient process for metal grain refinement and fatigue properties. The stainless steel 316L was investigated in terms of microstructure, texture, and roughness. This research covers the effects of chosen shot peening parameter on the BG‐coating properties on the obtained results. Shot peening was carried using two different sets of parameters as conventional shot peening, and severe shot peening. Wettability, roughness, microstructure, coating thickness, and corrosion behavior of coated sample were investigated in terms of potentiodynamic polarization and electrochemical impedance spectroscopy in simulated body fluid (SBF) solutions at 37°C. The results indicated that the coating thickness decreased from 35.5 ± 10 µm for coated not peened (CNP) to 20 ± 5 and 17 ± 2 µm for coated conventionally shot‐peened (CCSP) and coated severely shot‐peened (CSSP), respectively. As well as, the water contact angle of CSSP sample was equal to 15.71° which is much lower than CNP (20.7°). The protection ability of the tested samples in the SBF was improved in the following order: CCSP < CNP < CSSP.
Supplementary data from Colorectal Cancer Screening: How Health Gains and Cost-Effectiveness Vary by Ethnic Group, the Impact on Health Inequalities, and the Optimal Age Range to Screen
Authors: McLeod Melissa , Kvizhinadze Giorgi , Boyd Matt , Barendregt Jan , Sarfati Diana , Wilson Nick , Blakely Tony 
Published: April 2023

<p>S1 Table 1 Values of transition probability estimates and the 95% credible intervals for the natural history parameters; SFig 1 Model predicted versus observed average colorectal cancer mortality counts per year (2007-2010) by age, sex and ethnicity; SFig 2 Health systems cost inputs by Dukes stage and clinical phase (y-axis log scale) for males (female cost inputs available on request from author); STable 2 Model validation: percentage reduction (95% confidence or uncertainty interval) in colorectal cancer mortality in MSLT model, selected RCTs and selected other simulation models; SFig 3 Tornado plots* for one-way sensitivity analyses of the total population incremental cost-effectiveness ratio (ICER â€ ); STable 3 Optimal CRC screening age-range for MÄ�ori; STable 4 Optimal CRC screening age-range for non-MÄ�ori</p>
Efficacy of estrogen releasing pellets. from Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts
Authors: Bieniasz Magdalena , Radhakrishnan Parvathi , Faham Najme , De La O Jean-Paul , Welm Alana L. 
Published: April 2023

<p>A. MCF7 tumor growth rate in NOD/SCID mice implanted with beeswax E2 pellets, commercial 0.72 mg/60 days E2 pellets (Innovative Research of America) and control mice. Both, 0.72 mg/60 days E2 and beeswax E2 pellets equally supported estrogen dependent tumor growth. In contrast, control mice not supplemented with E2 pellets failed to grow tumors. B. Quantification of E2 plasma levels 10 days post implantation of E2 pellets in NOD/SCID mice. The beeswax pellets yielded mean E2 plasma levels of 84 pg/ml with very little variation, which are comparable plasma estrogen levels released from commercially available E2 pellets.</p>
Supplementary figure 1 legend from Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient–Derived Xenografts and Mesothelin as a Biomarker of Tumor Response
Authors: Zhang Jingli , Khanna Swati , Jiang Qun , Alewine Christine , Miettinen Markku , Pastan Ira , Hassan Raffit 
Published: April 2023

<p>Semiquantitative assessment of mesothelin expression using H-score in mesothelioma patient derived xenografts. (A) NCI-Meso16: tumor with areas of strong membrane staining and intermingling of negative areas (H-score 230). (B) NCI-Meso21: tumor shows only focal membrane positivity (H-score 50). (C) NCI-Meso29: tumor shows nearly uniform strong membrane positivity (H-score 290). Original magnification 400x.</p>
Supplementary Figure S2 from Establishment of Patient-Derived Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response
Authors: Yebra Mayra , Bhargava Shruti , Kumar Avi , Burgoyne Adam M. , Tang Chih-Min , Yoon Hyunho , Banerjee Sudeep , Aguilera Joseph , Cordes Thekla , Sheth Vipul , Noh Sangkyu , Ustoy Rowan , Li Sam , Advani Sunil J. , Corless Christopher L. , Heinrich Michael C. , Kurzrock Razelle , Lippman Scott M. , Fanta Paul T. , Harismendy Olivier , Metallo Christian , Sicklick Jason K. 
Published: April 2023

<p>Fig. S2. Recapitulation of metabolic characteristics of parental tumors and SDH-deficiency by patient-derived mSDH GIST models. A.	Concentration of succinate in wildtype (WT) (n = 2), mSDHA (n = 1), mSDHB (n = 3), and mSDHC (n = 1) patient plasma. B.	Ratio of succinate to fumarate in WT (n = 2), mSDHA (n = 1), mSDHB (n = 3), and mSDHC (n = 1) patient plasma. C.	Percent labeling of M3 pyruvate from [U-13C5] glucose in mSDH GIST models grown for 48 h. D.	Percent labeling of M3 lactate from [U-13C5] glucose in mSDH GIST models grown for 48 h. E.	Per cell abundance of 2-hydroxyglutarate (2-HG) relative to WT in mSDH GIST models grown for 48 h. One-way ANOVA was performed for statistical analysis with *, P<0.05; ***, P<0.001; ****, P<0.0001. F.	mSDH GIST models were treated for 72 h with either DMSO or a 10-point dose range of 2-DG and cell viability was measured using the CellTiter-Glo viability assay. G.	mSDH GIST models were treated for 72 h with either DMSO or a 10-point dose range of 6-AN and cell killing was measured using the CellTiter-Glo viability assay.</p>
Surface charging and dose monitor on geosynchronous orbit satellite
Authors: Zheng Yuzhan , Zhang Qingxiang , Xiang Hongwen , Yao Shuai , Zheng Yi , Quan Lin 
Published: April 2023

Abstract
Based on the typical dielectric materials and devices of satellite, a surface charging and dose monitor (SCAD) was developed to measure the surface charging voltage, current, and dose under different shielding depths. The SCAD has been successfully launched into orbit on June 23, 2020. The measurement results on orbit show that the SCAD works normally, and the data of SCAD are reasonable. The results show that the radiation dose rate on geosynchronous orbit is about 0.4 mrad(Si)/s, and the maximum charging voltage is about −800 V during the initial measuring period. The charging voltage is consistent with the trends of geomagnetic disturbance Kp index. The on-orbit data provide basic data on surface charging and discharging effect and total dose effect, supporting the safe and reliable operation of the satellite.
Effect of different proportions of CNTs/Fe3O4 hybrid filler on the morphological, electrical and electromagnetic interference shielding properties of poly(lactic acid) nanocomposites
Authors: Wu Bozhen , Zhu Honghao , Yang Yuhao , Huang Jiang , Liu Tong , Kuang Tairong , Jiang Shaohua , Hejna Aleksander , Liu Kunming 
Published: April 2023

Abstract
Due to the shortage of petroleum resources, poly(lactic acid) (PLA), a biodegradable polymer, has been widely considered as a replacement for traditional petroleum-based polymers. Therefore, multifunctional PLA composites have become increasingly popular. In this study, conductive carbon nanotubes (CNTs) and magnetic nano-Fe3O4 fillers were melt-blended with PLA. The impact of CNTs and nano-Fe3O4 composition on the electrical and electromagnetic interference (EMI) shielding properties of PLA nanocomposites was investigated in detail by adjusting the CNTs-to-nano-Fe3O4 ratio. When the hybrid filler content was fixed at 10 wt%, the electrical conductivity results indicated that the addition of single CNTs could effectively improve the conductivity of the nanocomposites, while nano-Fe3O4 contribution was hardly noted. A suitable ratio of electromagnetic hybrid fillers can yield excellent synergistic effects in EMI shielding properties. The nanocomposites containing CNTs and nano-Fe3O4 in a 50:50 ratio exhibited excellent electrical conductivity (90.6 S·m−1) and EMI shielding effectiveness (EMI SE ∼ 40.5 dB). This is primarily because CNTs provide good electrical conductivity, but the addition of magnetic nano-Fe3O4 provides additional interfacial polarization and eddy current losses caused by its dielectric and magnetic properties. These properties synergistically result in an impedance mismatch, dielectric loss, and polarization relaxation of the composite materials, improving the shielding properties against electromagnetic waves. Further, it was found that changing the ratio of electromagnetic hybrid fillers also affected electromagnetic wave absorption. When the ratio of CNT-to-nano-Fe3O4 was 25:75, the nanocomposites had an EMI SE of 24.6 dB, and the absorptivity could reach the maximum (40.3%). Thus, this study provides a valuable reference for preparing multifunctional polymer nanocomposites by constructing electromagnetic hybrid filler networks.
Homogeneous ACM bundles on isotropic Grassmannians
Authors: Du Rong , Fang Xinyi , Ren Peng 
Published: April 2023

Abstract
In this paper, we characterize homogeneous arithmetically Cohen–Macaulay (ACM) bundles over isotropic Grassmannians of types 𝐵, 𝐶 and 𝐷 in terms of step matrices.
We show that there are only finitely many irreducible homogeneous ACM bundles by twisting line bundles over these isotropic Grassmannians.
So we classify all homogeneous ACM bundles over isotropic Grassmannians combining the results on usual Grassmannians by Costa and Miró-Roig.
Moreover, if the irreducible initialized homogeneous ACM bundles correspond to some special highest weights, then they can be characterized by succinct forms.
Total Roman domination on the digraphs
Authors: Zhang Xinhong , Song Xin , Li Ruijuan 
Published: April 2023

Abstract
Let

D
=

(

V
,
A

)

D=\left(V,A)

be a simple digraph with vertex set

V

V

, arc set

A

A

, and no isolated vertex. A total Roman dominating function (TRDF) of

D

D

is a function

h
:
V
→

{

0
,
1
,
2

}

h:V\to \left\{0,1,2\right\}

, which satisfies that each vertex

x
∈
V

x\in V

with

h

(

x

)

=
0

h\left(x)=0

has an in-neighbour

y
∈
V

y\in V

with

h

(

y

)

=
2

h(y)=2

, and that the subdigraph of

D

D

induced by the set

{

x
∈
V
:
h

(

x

)

≥
1

}

\left\{x\in V:h\left(x)\ge 1\right\}

has no isolated vertex. The weight of a TRDF

h

h

is

ω

(

h

)

=

∑

x
∈
V

h

(

x

)

\omega \left(h)={\sum }_{x\in V}h\left(x)

. The total Roman domination number

γ

t
R

(

D

)

{\gamma }_{tR}\left(D)

of

D

D

is the minimum weight of all TRDFs of

D

D

. The concept of TRDF on a graph

G

G

was introduced by Liu and Chang [Roman domination on strongly chordal graphs, J. Comb. Optim. 26 (2013), no. 3, 608–619]. In 2019, Hao et al. [Total Roman domination in digraphs, Quaest. Math. 44 (2021), no. 3, 351–368] generalized the concept to digraph and characterized the digraphs of order

n
≥
2

n\ge 2

with

γ

t
R

(

D

)

=
2

{\gamma }_{tR}\left(D)=2

and the digraphs of order

n
≥
3

n\ge 3

with

γ

t
R

(

D

)

=
3

{\gamma }_{tR}\left(D)=3

. In this article, we completely characterize the digraphs of order

n
≥
k

n\ge k

with

γ

t
R

(

D

)

=
k

{\gamma }_{tR}\left(D)=k

for all integers

k
≥
4

k\ge 4

, which generalizes the results mentioned above.
Comprehensive analysis of the role of SFXN family in breast cancer
Authors: Yuan Ding , Liu Jialiang , Sang Wenbo , Li Qing 
Published: April 2023

Abstract
The sideroflexin (SFXN) family is a group of mitochondrial membrane proteins. Although the function of the SFXN family in mitochondria has been widely recognized, the expression levels, role, and prognostic value of this family in breast cancer (BC) have not been clearly articulated and systematically analysed. In our research, SFXN1 and SFXN2 were significantly upregulated in BC versus normal samples based on Gene Expression Profiling Interactive Analysis 2 and the Human Protein Atlas databases. We found that high SFXN1 expression was significantly related to poor prognosis in BC patients and that high SFXN2 expression was significantly associated with good prognosis in BC patients. Gene Ontology analysis of the SFXN family was performed based on the STRING database to explore the potential functions of this family, including biological processes, cellular components, and molecular functions. Based on the MethSurv database, we found that two SFXN1 CpG sites (5′-UTR-S_Shelf-cg06573254 and TSS200-Island-cg17647431), two SFXN2 CpG sites (3′-UTR-Open_Sea-cg04774043 and Body-Open_Sea-cg18994254), one SFXN3 CpG site (Body-S_Shelf-cg17858697), and nine SFXN5 CpG sites (1stExon;5′-UTR-Island-cg03856450, Body-Open_Sea-cg04016113, Body-Open_Sea-cg04197631, Body-Open_Sea-cg07558704, Body-Open_Sea-cg08383863, Body-Open_Sea-cg10040131, Body-Open_Sea-cg10588340, Body-Open_Sea-cg17046766, and Body-Open_Sea-cg22830638) were significantly related to the prognosis of BC patients. According to the ENCORI database, four negative regulatory miRNAs for SFXN1 (hsa-miR-22-3p, hsa-miR-140-5p, hsa-miR-532-5p, and hsa-miR-582-3p) and four negative regulatory miRNAs for SFXN2 (hsa-miR-9-5p, hsa-miR-34a-5p, hsa-miR-532-5p, and hsa-miR-885-5p) were related to poor prognosis for BC patients. This study suggests that SFXN1 and SFXN2 are valuable biomarkers and treatment targets for patients with BC.
The role of social networks in academic discourse socialization: insights from degree-seeking multilingual international students in China
Authors: Li Wendong , Gong Yang 
Published: April 2023

Abstract
This study adopted a social network perspective to explore the academic discourse socialization experiences of eight degree-seeking multilingual international students at a university in eastern China. Based on a triangulation of ethnographic interviews, social network questionnaires, and supplementary sources (e.g., voluntarily submitted recordings, texts about academic exchanges), the study revealed five patterns of students’ social networks, including heterogeneous-sparse network, heterogeneous-dense network, homogeneous-sparse network, homogeneous-dense network, and balanced network. This resulting network typology was utilized to interpret the role of social networks in individuals’ socialization trajectories, which were observed to include affecting capacities to negotiate academic norms, structuring channels to build and transform expertise, and shaping space for multicompetence development. While different network connections demonstrated different roles, networks with similar characteristics could exert divergent impacts, highlighting the mediation of a range of individual and sociocultural dynamics. Based on the findings, the study contributes to critical multilingual studies by offering theoretical implications for socialization research on community and competence, and providing practical suggestions for research, education, and program administration in international education.