bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence
Authors: Zarubin Vanessa C. , Damme Katherine S. F. , Vargas Teresa , Osborne K. Juston , Norton Elizabeth S. , Briggs-Gowan Margaret , Allen Norrina B. , Wakschlag Laurie , Mittal Vijay A. 
Published: July 2023

AbstractBackgroundInhibitory control develops in early childhood, and atypical development may be a measurable marker of risk for the later development of psychosis. Additionally, inhibitory control may be a target for intervention.MethodsBehavioral performance on a developmentally appropriate Go/No-Go task including a frustration manipulation completed by children ages 3–5 years (early childhood; n = 107) was examined in relation to psychotic-like experiences (PLEs; ‘tween’; ages 9–12), internalizing symptoms, and externalizing symptoms self-reported at long-term follow-up (pre-adolescence; ages 8–11). ERP N200 amplitude for a subset of these children (n = 34) with electrophysiological data during the task was examined as an index of inhibitory control.ResultsChildren with lower accuracy on No-Go trials compared to Go trials in early childhood (F(1,101) = 3.976, p = 0.049), evidenced higher PLEs at the transition to adolescence 4–9 years later, reflecting a specific deficit in inhibitory control. No association was observed with internalizing or externalizing symptoms. Decreased accuracy during the frustration manipulation predicted higher internalizing, F(2,202) = 5.618, p = 0.004, and externalizing symptoms, F(2,202) = 4.663, p = 0.010. Smaller N200 amplitudes were observed on No-Go trials for those with higher PLEs, F(1,101) = 6.075, p = 0.020; no relationship was observed for internalizing or externalizing symptoms.ConclusionsLong-term follow-up demonstrates for the first time a specific deficit in inhibitory control behaviorally and electrophysiology, for individuals who later report more PLEs. Decreases in task performance under frustration induction indicated risk for internalizing and externalizing symptoms. These findings suggest that pathophysiological mechanisms for psychosis are relevant and discriminable in early childhood, and further, suggest an identifiable and potentially modifiable target for early intervention.
COVID-19 concerns among caregivers and vitamin A supplementation coverage among children aged 6–59 months in four countries in Western sub-Saharan Africa
Authors: Baker Melissa M , Janmohamed Amynah , Toure Djeinam , Dissieka Romance , Ndiaye Fatou , Khassanova Regina , Fofana Mohamed Lamine , Doledec David 
Published: July 2023

AbstractObjective:To assess child vitamin A supplementation (VAS) coverage in 2019 and 2020 and explore key factors, including COVID-19 concerns, that influenced VAS status in four sub-Saharan African countries.Design:Data from eight representative household surveys were used to assess VAS coverage. Multivariable logistic regression models examined the effect of rural/urban residence, child sex and age, caregiver education, COVID-19 concern and household wealth on VAS status.Setting:Nine (2019) and 12 (2020) districts in Burkina Faso, Côte d’Ivoire, Guinea and Mali.Participants:28 283 caregivers of children aged 6–59 months.Results:Between 2019 and 2020, VAS coverage increased in Burkina Faso (82·2–93·1 %), Côte d’Ivoire (90·3–93·3 %) and Mali (76·1–79·3 %) and decreased in Guinea (86·0 % to 81·7 %). Rural children had a higher likelihood of VAS uptake compared with urban children in Burkina Faso (adjusted OR (aOR) = 4·22; 95 % CI: 3·11, 5·72), Côte d’Ivoire (aOR = 5·19; 95 % CI: 3·10, 8·70) and Mali (aOR = 1·41; 95 % CI: 1·15, 1·74). Children aged 12–59 months had a higher likelihood of VAS uptake compared with children aged 6–11 months in Côte d’Ivoire (aOR = 1·67; 95 % CI: 1·12, 2·48) and Mali (aOR = 1·74; 95 % CI: 1·34, 2·26). Moderate-to-high COVID-19 concern was associated with a lower likelihood of VAS uptake in Côte d’Ivoire (aOR = 0·55; 95 % CI: 0·37, 0·80).Conclusion:The increase in VAS coverage from 2019 to 2020 suggests that COVID-19 concerns may not have limited VAS uptake in some African countries, though geographic inequities should be considered.
Single- and dual-source-strength focal boost planning in low-dose-rate prostate brachytherapy: feasibility study
Authors: Clark A. K. , Wright G. , Mason J. , Hulson O. , Henry A. , Rodda S. , Bownes P. 
Published: July 2023

Abstract

Introduction:
This study investigates the dose escalation to dominant intra-prostatic lesions (DILs) that is achievable using single-source-strength (SSS) and dual-source-strength (DSS) low-dose-rate (LDR) prostate brachytherapy and a sector-based plan approach.

Methods:
Twenty patients were retrospectively analysed. Image registration and planning were undertaken using VariSeed v9·0. SSS and DSS boost plans were produced and compared to clinical plans. Dosimetric robustness to seed displacement for SSS and DSS plans was compared to clinical plans using Monte Carlo simulations.

Results:
Fourteen out of 20 patients had DIL identifiable on magnetic resonance imaging. Median increase in sector D90 of 27% (p < 0·0001) and sector V150 of 31% (p < 0·0001) was achieved with SSS planning without exceeding local rectum and urethra dose constraints. DSS plans achieved dose distributions not statistically significantly different from the SSS plans with a median of eight fewer seeds and two fewer needles. SSS and DSS plan sensitivity to random seed displacement was similar to the clinical plans.

Conclusions:
Treatment planning using VariSeed to produce SSS and DSS focal boost plans is feasible for LDR prostate brachytherapy to achieve a median escalation in sector D90 of 27% without exceeding local urethral and rectal constraints. SSS and DSS plan dosimetric robustness was similar to clinical plan dosimetric robustness.
Dehydrated thin film media to rapidly estimate bioburden for planetary protection flight implementation
Authors: Dean Zachary S. , Stott Kristina , Schubert Wayne , Seto Emily P. , Chandrapati Sailaja 
Published: July 2023

AbstractPlanetary Protection (PP) is the practice of safeguarding solar system bodies from terrestrial biological contamination and screening the Earth against potentially harmful extraterrestrial biological contamination. On Earth, cleanrooms and spacecraft surfaces are assayed using swabs and wipes that are then heat shocked for 15 min at 80°C to select for spores. The samples are further processed using the pour-plate method and Petri plates (TSA plates), with trypticase soy agar (TSA) serving as the growth medium. This sampling and processing procedure, called the NASA Standard Assay (NSA), is used by PP engineers around the world. Recent years have seen an increase in the incorporation of state-of-the-art technology, such as membrane filtration, into the NSA, with a push for implementing environmentally friendly technology into day-to-day activities. Dehydrated thin film media, such as Petrifilm Rapid Aerobic Count (RAC) plates, suit these goals as an alternative method to TSA plates. RAC plates show bacterial growth (and distinguish colonies from foreign particles such as bubbles) faster than TSA plates due to the incorporation of chromogenic colour indicators in the media. RAC plates also possess a much smaller environmental footprint than TSA plates, and are designed to evaluate even some of the challenging-to-detect environmental organisms, including spreaders that fill over 25% of the plate area in only a few hours. With these benefits in mind the PP Group at the NASA Jet Propulsion Laboratory took on the task of comparing RAC plates directly to TSA plates within the context of the NSA. Not only were the RAC plates able to detect surface environmental samples and in vitro spiked samples equivalent to NSA-processed TSA plates, but spreader organisms were countable on RAC plates at culture densities 10- to 100-fold greater than on TSA plates. In addition, RAC plates showed a robust, linear detection capability when challenged with membrane filter incorporation and organisms were easily acquired from RAC plates for archiving or post-processing experiments including MALDI-TOF bacterial identification. With their ease of use, small footprint, and both rapid and accurate bioburden measurements, RAC plates have the potential to overcome limitations posed by current PP culturing protocols.
Collaborating to reduce food waste: building collaborative advantage in local food systems
Authors: Nadeau Nikki , Koebele Elizabeth A. 
Published: July 2023

Abstract
Food loss and waste throughout the food supply chain is a growing issue with significant economic, social and environmental implications. Wasted food represents lost profits for the food industry, increased food insecurity in communities and the unnecessary production of greenhouse gas emissions, among many other detrimental consequences. Due to the large number of stakeholders involved in the food supply chain and the complexity of their relationships, there is increasing interest in addressing food waste issues through collaborative governance approaches, such as food policy councils (FPCs). Assessing how FPCs engage diverse stakeholders and organizations in food waste reduction efforts can provide important lessons for improving local food systems governance more broadly and contribute to the creation of more sustainable food systems. To do this, we leverage the theoretical concept of ‘collaborative advantage’ to analyze how FPCs foster collaboration, both internally and with external partners, to achieve policy and programmatic goals that individual stakeholders could not achieve alone. Drawing on plan documents and semi-structured interviews with members of five FPCs across the USA, we find that FPCs can foster collaborative advantage by establishing comprehensive food system plans, systematically measuring progress toward objectives, and transparently communicating the evidence of their progress to the communities they serve.
Private Equity Blues: Warner Music Group, Nonesuch Records, and Jazz in the Era of Financialization
Authors: Chapman Dale 
Published: July 2023

AbstractSince the 1980s, the Nonesuch label, a longstanding subsidiary of the Warner Music Group (WMG), has become noteworthy for its steady market performance during a period of volatility for media multinationals. Nonesuch Records, having once been an adventurous boutique classical label under Teresa Sterne, has developed over the last three decades as a creatively idiosyncratic and commercially successful “adult” imprint under Robert Hurwitz, the erstwhile director of the Munich-based Edition of Contemporary Music jazz label.Nonesuch has not historically been understood as a jazz label, though it has served as a home for a few jazz acts, including Bill Frisell, Fred Hersch, and the World Saxophone Quartet. By the early years of the new millennium, though, Nonesuch had become one of the few major label subsidiaries willing to maintain an active roster of jazz instrumentalists, harnessing its diversified roster as a source of strength.This paper examines the Nonesuch label's cultivation of a distinctive jazz niche and situates this development against the backdrop of a period of structural turbulence for the WMG. The leveraged buyout of WMG in 2004, which precipitated the dissolution of the Warner Jazz subsidiary and the transfer of much of its jazz roster to Nonesuch, reflects a contemporary logic of financialization, where value extraction has become the overriding goal of corporate restructuring. Mergers and acquisitions enacted at the uppermost reaches of major label corporate hierarchies pass along significant costs to the label subsidiaries and their artist rosters, installing precarity at the core of the music industry's creative ecologies.
Multi‐Wavelength (L and S Band) Study of Ionospheric Irregularities From an Anomaly Crest Location
Authors: Biswas Trisani , Weiss Jan‐Peter , Paul Ashik 
Published: July 2023

AbstractThis paper reports observation of moderate to intense scintillations, at S band of Indian Regional Navigation Satellite System (IRNSS). During current solar cycle 25, these occurrences are probably being reported for the first time, from a low‐latitude station Calcutta (22.58°N, 88.38°E geographic; magnetic dip 34.54°), located near the northern crest of Equatorial Ionization Anomaly. Efforts have been made to analyze irregularity dynamics at IRNSS S band, along with a comparative study at GNSS L1 to characterize occurrence and evolution of multiscale irregularity structures. Power spectral analysis technique has been applied on recorded C/NO, during scintillation patches, to measure east‐west zonal drift velocity. Efforts are also made to study intensity of signal perturbation at L5 frequency of IRNSS, compared to S band, when observed simultaneously, during period of ionospheric scintillation. Concurrent irregularity dynamics at L1, L5, and S band, particularly from a low‐latitude station, has not been extensively reported earlier. Data is recorded during vernal equinox (February–April 2022) of current solar cycle. Results of this study show occurrence of simultaneous night‐time scintillation at L1, L5, and S band. East‐west zonal drift velocity of irregularity, obtained from S band observations are found to decrease with the progress of time during 20–23 LT having a maximum value of 125 m/s. At GNSS L1, hourly average value of the velocity, is observed to maximize during 20–21 LT. Simultaneous observation of scintillation effects at L5 and S band of IRNSS led to loss‐of‐lock at L5, while no such occurrence was noted at S band.
Variations in the 30–60‐Day Intra‐Seasonal Variability of Spring Precipitation Over the Mid‐Low Reaches of the Yangtze River and the Possible Mechanism
Authors: Yu Shui , Sun Jianqi 
Published: July 2023

AbstractThe precipitation intra‐seasonal variability (ISV) has an important influence on extreme precipitation events, profoundly influencing agricultural activities over the mid‐low reaches of the Yangtze River (MLRYR). Spectrum analysis reveals the existence of 30–60‐day ISV in the MLRYR spring precipitation. The mechanism analysis indicates that, on the intra‐seasonal time scale, the MLRYR precipitation ISV is primarily driven by a wave train over the Eurasian continent. The wave train, with an anomalous anticyclone (cyclone) over the East European Plain and an anomalous cyclone (anticyclone) over Central Asia, could cause more (less) precipitation over the MLRYR. On the inter‐annual and inter‐decadal time scales, the precipitation ISV intensity is influenced by a meridional dipole pattern of the westerly jet stream (WJS) over the Eurasian continent. The positive WJS pattern facilitates the barotropic instability generation and 30–60‐day ISV growth over the East European Plain. Therefore, the ISV intensity of the pronounced wave train is enhanced and further intensifies the MLRYR spring precipitation ISV. In contrast, the negative WJS pattern is unfavorable for regional barotropic instability generation, and therefore the spring precipitation ISV intensity over the MLRYR would be weak. Further analysis shows that the underlying snow cover and soil temperature anomalies could have a contribution to forming the WJS dipole pattern through changing the meridional temperature gradient. The results of this study could deepen our understanding of the spring precipitation ISV over the MLRYR and the mechanisms.
Chemical Weathering Intensity as a Reliable Indicator for Southwest Summer Monsoon Reconstruction: Evidence From Clay Minerals of Qionghai Lake Sediments Since the Last Glacial Maximum
Authors: Yu Xiaoli , Wang Gen , Zhang Ting , Ma Xueyun , Zhang Xiaomei , Li Lun , Li Zelong , Guo Zengguang , Wei Zhifu , Wang Yongli , Zhou Shixin 
Published: July 2023

AbstractStudying the evolution history of the southwest summer monsoon (SSM) throughout geological time, particularly during its strongest period in the Holocene, can improve our understanding of its variation and driving mechanisms, and even help predict future climate changes, due to its significant social and economic implications. Here, we reconstructed the history of chemical weathering intensity since the Last Glacial Maximum (LGM) based on clay mineral proxies [(illite/smectite)/(illite + chlorite) and illite crystallinity] obtained from Qionghai Lake sediments and examined its response to paleoclimate and SSM. Our findings indicate that the intensity of chemical weathering generally aligned with changes in paleoclimate, exhibiting strong chemical weathering intensity during warm and humid climate conditions. In addition, the intensity of chemical weathering basically tracks the evolution of the SSM since the LGM. Our results support the view that the highest SSM intensity occurred during the early‐middle Holocene, followed by gradual weakening during the late Holocene, with Northern Hemisphere summer insolation being the primary driver of the SSM evolution. The variations of the SSM and the corresponding intensity of chemical weathering were also influenced by the cumulative effects of glacier boundary conditions, North Atlantic climate fluctuations, and Intertropical Convergence Zone migrations.
Lower Crustal Rheology Controls Strain Partitioning and Mode of Intracontinental Deformation
Authors: Xu Xi , Zuza Andrew V. , Yin An , Yu Peng , Chen Zhiyong , Zhao Chongjin , Wang Baodi , Chen Hanlin , Lin Xiubin , Wu Lei , Kuang Xingtao , Tian Hefeng , Yin Qihang , Yang Shufeng 
Published: July 2023

AbstractThe factors that control strain partitioning along plate boundaries and within continental interiors remains poorly resolved. Plate convergence may be accommodated via distributed crustal shortening or discrete crustal‐scale strike‐slip faulting, but what controls these differing modes of deformation is debated. Here we address this question by examining the actively deforming regions that surround the Tarim Basin in central Asia, where deformation is uniquely partitioned into predominately strike‐slip faults in the east and distributed fold‐thrust belts in the west to accommodate Cenozoic India‐Asia plate convergence. We present integrated geological and geophysical observations to elucidate patterns in crustal deformation and compositional structure in and around the Tarim Basin. The thrust‐dominated western Tarim Basin correlates with a strongly‐magnetic lower crust, whereas strike‐slip faulting along the eastern margins of the Tarim Basin lack such magnetic signals. We suggest that the lower crust of the western Tarim is more mafic and stronger than in the east, which impacts intra‐plate strain partitioning. A stronger lower crust results in vertical decoupling to drive mid‐crust horizontal detachments and facilitate thrust faulting, whereas a more homogenized crust favored vertical transcrustal strike‐slip faulting. These rheological differences likely originated from the impingement of the Permian Tarim plume focused in the west. A comparison with the Longmen Shan of eastern Tibetan Plateau reveals remarkably similar strain partitioning that correlates with variations in foreland rheology. Our results highlight how variations in lower‐crust viscosity impact strain partitioning in an intra‐plate setting and how plume processes exert a strong control on later continental tectonic processes.
Metastatic pattern of ovarian cancer delineated by tracing the evolution of mitochondrial DNA mutations
Authors: Xu Zhiyang , Zhou Kaixiang , Wang Zhenni , Liu Yang , Wang Xingguo , Gao Tian , Xie Fanfan , Yuan Qing , Gu Xiwen , Liu Shujuan , Xing Jinliang 
Published: July 2023

AbstractOvarian cancer (OC) is the most lethal gynecologic tumor and is characterized by a high rate of metastasis. Challenges in accurately delineating the metastatic pattern have greatly restricted the improvement of treatment in OC patients. An increasing number of studies have leveraged mitochondrial DNA (mtDNA) mutations as efficient lineage-tracing markers of tumor clonality. We applied multiregional sampling and high-depth mtDNA sequencing to determine the metastatic patterns in advanced-stage OC patients. Somatic mtDNA mutations were profiled from a total of 195 primary and 200 metastatic tumor tissue samples from 35 OC patients. Our results revealed remarkable sample-level and patient-level heterogeneity. In addition, distinct mtDNA mutational patterns were observed between primary and metastatic OC tissues. Further analysis identified the different mutational spectra between shared and private mutations among primary and metastatic OC tissues. Analysis of the clonality index calculated based on mtDNA mutations supported a monoclonal tumor origin in 14 of 16 patients with bilateral ovarian cancers. Notably, mtDNA-based spatial phylogenetic analysis revealed distinct patterns of OC metastasis, in which a linear metastatic pattern exhibited a low degree of mtDNA mutation heterogeneity and a short evolutionary distance, whereas a parallel metastatic pattern showed the opposite trend. Moreover, a mtDNA-based tumor evolutionary score (MTEs) related to different metastatic patterns was defined. Our data showed that patients with different MTESs responded differently to combined debulking surgery and chemotherapy. Finally, we observed that tumor-derived mtDNA mutations were more likely to be detected in ascitic fluid than in plasma samples. Our study presents an explicit view of the OC metastatic pattern, which sheds light on efficient treatment for OC patients.
Cancer-associated fibroblasts: from basic science to anticancer therapy
Authors: Yang Dakai , Liu Jing , Qian Hui , Zhuang Qin 
Published: July 2023

AbstractCancer-associated fibroblasts (CAFs), as a central component of the tumor microenvironment in primary and metastatic tumors, profoundly influence the behavior of cancer cells and are involved in cancer progression through extensive interactions with cancer cells and other stromal cells. Furthermore, the innate versatility and plasticity of CAFs allow their education by cancer cells, resulting in dynamic alterations in stromal fibroblast populations in a context-dependent manner, which highlights the importance of precise assessment of CAF phenotypical and functional heterogeneity. In this review, we summarize the proposed origins and heterogeneity of CAFs as well as the molecular mechanisms regulating the diversity of CAF subpopulations. We also discuss current strategies to selectively target tumor-promoting CAFs, providing insights and perspectives for future research and clinical studies involving stromal targeting.