bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I/II Trial of Carboplatin, Nab-paclitaxel, and Pembrolizumab for Advanced Non–Small Cell Lung Cancer: Hoosier Cancer Research Network LUN13-175
Authors: Gentzler Ryan D , Mohindra Nisha A , Jalal Shadia I , Reckamp Karen L , Hall Richard D , Hanna Nasser H , Chae Young Kwang , Koczywas Marianna , Helenowski Irene B , Patel Jyoti D 
Published: June 2023

Abstract

Background
Combination chemotherapy and immunotherapy regimens have significantly improved survival for patients with previously untreated advanced non–small cell lung cancer (NSCLC). Improvements in overall survival (OS) in two separate pembrolizumab trials have demonstrated survival improvements over chemotherapy alone, regardless of PD-L1 status. The optimal chemotherapy backbone for combination with immunotherapy is unknown. We hypothesized nab-paclitaxel may be a well-suited platinum partner to use in combination with checkpoint inhibitor therapy for both adenocarcinoma and squamous histology and conducted a phase I/II trial to assess the efficacy of this regimen in advanced NSCLC.

Methods
Adult patients with previously untreated, stage IIIB/IV NSCLC (any histology) with an Eastern Cooperative Oncology Group performance status of 0-1, any PD-L1 expression, and no EGFR mutations or ALK translocations, received carboplatin area under the curve (AUC) 6 day 1, nab-paclitaxel 100 mg/m2 days 1, 8, 15, and pembrolizumab 200 mg day 1 q21 days for 4 cycles followed by maintenance pembrolizumab q3w. Co-primary endpoints were progression-free survival (PFS) and overall response rate (ORR).

Results
Forty-six evaluable patients enrolled, 14 in phase I and 32 in phase II, from June 2015 to July 2018 with a median duration of follow-up of 35.4 months. Median time from enrollment to data lock was 42 months. In the ITT population, the ORR was 35%, median PFS was 5.6 months (95% CI, 4.6-8.2), and median OS was 15.4 months (CI, 12.4-28.1). There were no statistical differences in PFS or OS by PD-L1 status. The 2- and 3-year landmark OS rates were 33% and 24%, respectively.

Conclusion
Carboplatin, nab-paclitaxel, and pembrolizumab are a safe and effective regimen for patients with both squamous and nonsquamous NSCLC. Although this study did not meet the prespecified endpoints, the median and landmark OS results are consistent with durable benefit of this regimen as seen in phase III trials for first-line treatment of advanced NSCLC.
Adhesion of dental ceramic materials to titanium and titanium alloys: a review
Authors: Parushev Ivaylo , Dikova Tsanka , Katreva Iveta , Gagov Yavor , Simeonov Simeon 
Published: June 2023

Abstract
In recent years, the application of titanium and its alloys for production of metal frameworks for metal–ceramic fixed partial dentures (FPDs) has been increasing. They are fabricated mainly by casting, CAD/CAM milling and selective laser melting. Manufacturing technologies affect the surface characteristics of the metal, which in turn affects the adhesion in the metal–ceramic system. Therefore, the purpose of the present article is to analyse the information about the adhesion of dental ceramics to pure titanium and its alloys, emphasizing the methods most commonly applied to improve adhesion. Based on the papers published last 10 years, the pure titanium and its alloys, the main technologies for their production and the porcelains applied in the fabrication of metal–ceramic FPDs are examined. It is summarized that the methods for increasing the adhesion strength of the porcelains to the titanium and Ti alloys can be classified into five large groups: mechanical, physical, chemical methods, application of bonding agents and combined treatments, as clear boundaries between them cannot be set. In the last decade, the successful technologies for improving the adhesion strength of Ti and its alloys to the porcelain usually consist of a combination of successive treatments of the metal surface. Abrasion of the titanium surface by sandblasting is most often used initially. At the next stage, a bonding agent or other type of intermediate layer of different coatings is applied to the metal, which further improves the adhesion strength to the porcelain.
Runx1 regulates critical factors that control uterine angiogenesis and trophoblast differentiation during placental development
Authors: Kannan Athilakshmi , Beal Jacob R , Neff Alison M , Bagchi Milan K , Bagchi Indrani C 
Published: June 2023

Abstract
During early pregnancy in humans and rodents, uterine stromal cells undergo a remarkable differentiation to form the decidua, a transient maternal tissue that supports the growing fetus. It is important to understand the key decidual pathways that orchestrate the proper development of the placenta, a key structure at the maternal–fetal interface. We discovered that ablation of expression of the transcription factor Runx1 in decidual stromal cells in a conditional Runx1-null mouse model (Runx1d/d) causes fetal lethality during placentation. Further phenotypic analysis revealed that uteri of pregnant Runx1d/d mice exhibited severely compromised decidual angiogenesis and a lack of trophoblast differentiation and migration, resulting in impaired spiral artery remodeling. Gene expression profiling using uteri from Runx1d/d and control mice revealed that Runx1 directly controls the decidual expression of the gap junction protein connexin 43 (also known as GJA1), which was previously shown to be essential for decidual angiogenesis. Our study also revealed that Runx1 controls the expression of insulin-like growth factor (IGF) 2 and IGF-binding protein 4 (IGFBP4) during early pregnancy. While Runx1 deficiency drastically reduced the production of IGF2 by the decidual cells, we observed concurrent elevated expression of the IGFBP4, which regulates the bioavailability of IGFs, thereby controlling trophoblast differentiation. We posit that dysregulated expression of GJA1, IGF2, and IGFBP4 in Runx1d/d decidua contributes to the observed defects in uterine angiogenesis, trophoblast differentiation, and vascular remodeling. This study therefore provides unique insights into key maternal pathways that control the early phases of maternal–fetal interactions within a critical window during placental development.
On Resisting Extortion—From Everyday Resistance to Vigilantism
Authors: Ley Sandra 
Published: June 2023

Abstract
Resisting Extortion, by Eduardo Moncada, masterfully disentangles the logic and dimensions of criminal extortion, as well as the various ways in which communities seek to resist this and other forms of criminal activity. In this book, Moncada argues that criminals’ time horizons largely dictate the subsequent forms of civil resistance, which are simultaneously affected by the criminal capture of the police, as well as the prevailing relationships among local businesses and between businesses and political authorities. With major conceptual clarity, Moncada disentangles and reframes the complex phenomena that underlie extortion dynamics. Through careful comparative research, Moncada provides a new and fresh understanding of both extortion and collective action, across three different countries. Resisting Extortion is a major contribution at different levels, from theory development to comparative analysis, as well as a robust research design and extensive fieldwork. Readers across academic fields, along with activists and journalists, will benefit from the book’s insights on the effective organization and resistance strategies in the face of crime and insecurity.
Engineered Staphylococcus auricularis Cas9 with high‐fidelity
Authors: Wei Nan , Shang Lu , Liu Jing , Wang Mi , Liu Yingchun , Zhu Chuangang , Fei Chenzhong , Zhang Lifang , Yang Fayu , Gu Feng 
Published: June 2023

AbstractCRISPR‐Cas9 is a versatile gene editing tool with a broad application of basic research and clinical therapeutics. However, the potential impact caused by off‐target effects remains a critical bottleneck. The small Cas9 ortholog from Staphylococcus auricularis (SauriCas9) was identified, which recognizes a 5′‐NNGG‐3′ protospacer adjacent motif (PAM), exhibiting high activity for genome editing. Recently, we also reported enhanced‐fidelity Staphylococcus aureus Cas9 (efSaCas9), which harbors a single mutation N260D. Protein sequence alignment revealed that SauriCas9 has 62.4% sequence identity with SaCas9. Because SauriCas9 is more flexible in recognizing the target sequence with PAM of 5′‐NNGG‐3′ than SaCas9 of 5′‐NNGRRT‐3′ PAM, we sought to test whether key mutation(N260D) or adjacent residue mutation in efSaCas9 can be appliable to SauriCas9. With this concept, two engineered SauriCas9 variants (SauriCas9‐HF1, harboring the N269D mutation; SauriCas9‐HF2, harboring the D270N mutation) dramatically improved targeting specificity by targeted deep sequencing and GUIDE‐seq. At certain sites, reduced off‐target effects (approximately 61.6‐ and 111.9‐fold improvements) of SauriCas9‐HF2 compared with wild‐type SauriCas9 were observed. Overall, two identified SauriCas9 variants (SauriCas9‐HF1 and SauriCas9‐HF2) expand the utility of the CRISPR toolkit for research and therapeutic applications.
Professional Development in Health Sciences: Scoping Review on Equity, Diversity, Inclusion, Indigeneity, and Accessibility Interventions
Authors: Liblik Kiera , Desai Veeral , Yin Grace , Ng Rebecca , Maho Sigi , Cohen Natasha , Soleas Eleftherios K. 
Published: June 2023

Introduction:
Equity, diversity, inclusion, indigeneity, and accessibility (EDIIA) are critical considerations in the formation of professional development (PD) programs for health care workers. Improving EDIIA competency in health care serves to enhance patient health, staff confidence and well-being, delivery of care, and the broader health care system. There is a gap in the literature as to the efficacy of EDIIA-based PD programs and their individual components. The present article will review available quantitative data pertaining to EDIIA-based PD programs for health care workers as well as their effectiveness.

Methods:
A scoping review of articles published in the EBSCOhost, MEDLINE, PubMed, EMBASE, and CINAHL databases was performed. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.

Results:
A total of 14,316 references were identified with 361 reaching full-text review. A final 36 articles were included in the scoping review with 6552 total participants (72.9% women; 26.9% men; 0.2% nonbinary). EDIIA-based PD interventions were developed around the topics of culture (n = 22), gender (n = 11), sexual orientation (n = 9), indigeneity (n = 6), race (n = 6), ableism (n = 1), and ageism (n = 1).

Discussion:
Despite an increased interest in developing EDIIA-based PD curricula for health care workers, there are glaring disparities in the quality of care received by marginalized and equity-seeking populations. The present scoping review delineated key features which were associated with increased quantitative efficacy of EDIIA-based PD training programs. Future work should focus on large-scale implementation and evaluation of these interventions across health care sectors and levels of training.
REDH: A database of RNA editome in hematopoietic differentiation and malignancy
Authors: Xu Jiayue , He Jiahuan , Yang Jiabin , Wang Fengjiao , Huo Yue , Guo Yuehong , Si Yanmin , Gao Yufeng , Wang Fang , Cheng Hui , Cheng Tao , Yu Jia , Wang Xiaoshuang , Ma Yanni 
Published: June 2023

Abstract

Background:
The conversion of adenosine (A) to inosine (I) through deamination is the prevailing form of RNA editing, impacting numerous nuclear and cytoplasmic transcripts across various eukaryotic species. Millions of high-confidence RNA editing sites have been identified and integrated into various RNA databases, providing a convenient platform for the rapid identification of key drivers of cancer and potential therapeutic targets. However, the available database for integration of RNA editing in hematopoietic cells and hematopoietic malignancies is still lacking.

Methods:
We downloaded RNA sequencing (RNA-seq) data of 29 leukemia patients and 19 healthy donors from National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database, and RNA-seq data of 12 mouse hematopoietic cell populations obtained from our previous research were also used. We performed sequence alignment, identified RNA editing sites, and obtained characteristic editing sites related to normal hematopoietic development and abnormal editing sites associated with hematologic diseases.

Results:
We established a new database, "REDH", represents RNA editome in hematopoietic differentiation and malignancy. REDH is a curated database of associations between RNA editome and hematopoiesis. REDH integrates 30,796 editing sites from 12 murine adult hematopoietic cell populations and systematically characterizes more than 400,000 edited events in malignant hematopoietic samples from 48 cohorts (human). Through the Differentiation, Disease, Enrichment, and knowledge modules, each A-to-I editing site is systematically integrated, including its distribution throughout the genome, its clinical information (human sample), and functional editing sites under physiological and pathological conditions. Furthermore, REDH compares the similarities and differences of editing sites between different hematologic malignancies and healthy control.

Conclusions:
REDH is accessible at http://www.redhdatabase.com/. This user-friendly database would aid in understanding the mechanisms of RNA editing in hematopoietic differentiation and malignancies. It provides a set of data related to the maintenance of hematopoietic homeostasis and identifying potential therapeutic targets in malignancies.
9-Minute Withdrawal Time Improves Adenoma Detection Rate Compared With 6-Minute Withdrawal Time During Colonoscopy
Authors: Aziz Muhammad , Haghbin Hossein , Gangwani Manesh Kumar , Nawras Mohamad , Nawras Yusuf , Dahiya Dushyant Singh , Sohail Amir Humza , Lee-Smith Wade , Kamal Faisal , Shaukat Aasma 
Published: June 2023

Introduction:
Adenoma detection rate (ADR) is a quality metric that has been emphasized by multiple societies as improved ADR leads to reduced interval colorectal cancer (CRC). It is postulated that increased withdrawal time (WT) can lead to higher ADR. Multiple randomized controlled trials (RCTs) were undertaken to evaluate this. We performed a systematic review and meta-analysis of RCTs to analyze the impact of higher WT on ADR during colonoscopy.

Methods:
The following databases were comprehensively searched through November 8, 2022: Embase, MEDLINE, Cochrane, Web of Science, and Google Scholar. Only RCTs were eligible for inclusion. We applied the random effects model using the DerSimonian Laird approach and calculated risk ratio (RR) for binary outcomes and mean difference (MD) for continuous outcomes. 95% CI and P values were generated.

Results:
A total of 3 RCTs with 2159 patients were included of which 1136 patients were included in the 9-minute withdrawal group (9WT) and 1023 patients in the 6-minute withdrawal group (6WT). The mean age range was 53.6 to 56.8 years and the male gender was 50.7%. The overall ADR was significantly higher for 9WT (RR=1.23; 95% CI, 1.09-1.40; P<0.001). The overall adenoma per colonoscopy (APC) was also higher for the 9WT group (MD: 0.14; 95% CI, 0.04-0.25; P=0.008).

Conclusion:
The 9-minute withdrawal time improved ADR and APC compared with the 6-minute withdrawal. Given the high-quality evidence, we recommend that clinicians at least perform a 9-minute withdrawal to achieve higher quality metrics including ADR to reduce interval CRC.
Application of high-flow nasal cannula oxygen therapy in patient with pulmonary edema following cesarean-section under combined spinal-epidural anesthesia: A case report
Authors: Lee Taeil , Shinn Helen Ki , Kim Na Eun , Kim Doyeon 
Published: June 2023

Background:
High-flow nasal cannula (HFNC), which overcomes the disadvantages of the existing low flow mask, is an efficient method that can immediately provide a high volume of heated oxygen to the patient.[1] Therefore, this case reports a case in which HFNC was applied to a pregnant with acute respiratory failure.

Case:
A 37-year-old woman pregnant (GA 30 + 5 weeks) with twin was diagnosed with preeclampsia. It was decided to perform an emergency Cesarean-section under combined spinal-epidural technique worsening respiratory failure. After delivery, maternal dyspnea was not alleviated applying of O28 L/min via facial mask. Thus, high-flow nasal cannula (HFNC) oxygen therapy was applied (60 L/min, partial pressure of oxygen (FiO2) 80%) and SpO2 subsequently rose to 98% and the patient’s dyspnea was resolved.

Conclusions:
HFNC is a safe device that can effectively provide oxygen to pregnant with acute respiratory failure.
Optimal procedure and characteristics in using five times sit to stand test among older adults: A systematic review
Authors: Albalwi Abdulaziz Aoudh , Alharbi Ahmad Abdullah 
Published: June 2023

Background:
Falls are a major concern for people of all ages, especially older adults with declining physical functions and deteriorating muscle strength. The Five Times Sit to Stand Test is used for the assessment of lower limb strength along with balance and postural control. Therefore, the systematic review at hand aimed to determine the optimal procedure and characteristics among older adults.

Methods:
The following databases served as the primary sources through which the target studies were searched for and obtained for review. They included Google Scholar, Pedro, BIOMED Central, Cochrane Library, MEDLINE, PUBMED and Science DIRECT. With the aim of fulfilling the eligibility criteria, 16 full-text studies were included and the quality assessment was performed. using the Thomas Tool.

Results:
The total number of the subjects who participated in the included studies was 15,130 and the ages of the aforementioned participants ranged from 60 to 80 years. In 15 of the studies, a stopwatch was used as the scoring method where the mean chair height of 42 cm was reported. Two studies reported that no significant influence of the arm position (P = .096) on the time allocated for test completion was identified. However, posterior foot placement (P < .001) led to shorter times of completion. Individuals who are unable to complete the test are more susceptible to activities of daily living related disabilities (P < .01) when compared to fall risk (P = .09).

Conclusion:
The Five Times Sit-to-Stand Test is a safe test, providing added value to apply risk for falls in people at moderate risk and in healthy populations using standardized chair heights and stopwatches.
Effect of Chinese Medicines combined with transarterial chemoembolization on primary hepatic carcinoma: A systematic review and meta-analysis
Authors: Xu Jianyuan , Shan Yue , Zhang Chenxia , Hong Zehua , Qiu Yuanwang 
Published: June 2023

Background:
To systematically evaluate the survival rate and postoperative adverse reactions of patients with hepatocellular carcinoma treated with traditional Chinese medicine combined with TACE by meta-analysis.

Methods:
Four major literature databases (Cochrane Library, Embase, PubMed, and Web of Science) were retrieved to collect published English articles since 2009. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results:
This meta-analysis included 8 prospective studies published between 2009 and 2019. Due to moderate heterogeneity (P < .05, I
2 = 54.8%), Therefore, the random effect model is used to analyze the data, so as to explore the relationship between CMs combined with TACE treatment and survival rate and postoperative adverse reactions. All the comprehensive test results show that there is a statistical significance between CMs combined with TACE treatment and survival rate. (OR = 1.88, 95% CI 1.34–2.64, P = .03). Then subgroup analysis and sensitivity analysis were carried out. The results indicated that the overall results ranged from 1.12(95% CI = 1.03–1.11) to 1.21(95% CI = 1.22–1.33).

Conclusions:
The 1-year survival rate of patients treated with traditional Chinese medicine TACE is a protective factor, and the quality score included in the study affects the evaluation of the effective dose. At the same time, traditional Chinese medicine combined with TACE has nothing to do with the reduction of postoperative complications.
Amplatzer amulet versus watchman device for percutaneous left atrial appendage closure: A systematic review and meta-analysis
Authors: Jaiswal Vikash , Ang Song Peng , Shrestha Abhigan Babu , Wajid Zarghoona , Endurance Evbayekha Osas , Ayoobkhan Fathima Shehnaz , Khan Shazia , Garimellla Vamsi , Huang Helen , Ghanim Mohammed , Song David , Sharma Prachi , Alraies M. Chadi , Biswas Monodeep 
Published: June 2023

Background:
The Amplatzer Amulet (AA) and Watchman devices (WD) are the 2 most frequently used devices for percutaneous LAA closure globally.

Objective:
To evaluate the safety and clinical outcomes associated with these 2 devices in patients undergoing percutaneous LAA closure.

Method:
We systematically searched all electronic databases from inception until February 21, 2023. The primary endpoint was procedure related complications. Secondary endpoints were device related thrombus, stroke, cardiovascular mortality, peri device leak, systemic embolism, and all-cause mortality.

Results:
A total of 3 randomized clinical trials with 2150 patients were included in this meta-analysis. The mean age was 75 and 76 years in the Amplatzer group and in the Watchman group, respectively. The odds of procedure-related complications (OR, 1.80 [95% CI: 1.21–2.67], P < .001) were significantly higher among patients with AA compared to the WD. However, the odds of all-cause mortality (OR, 0.75 (95% CI: 0.49–1.16), P = .20), stroke (OR, 0.79 [95% CI: 0.47–1.34], P = .39), systemic/pulmonary embolism (OR, 1.34 [95% CI: 0.30–6.04], P = .70), and major bleeding (OR, 1.10 [95% CI: 0.83–1.48], P = .50) were comparable between the two devices. The odds of device related thrombus (OR, 0.72 [95% CI: 0.46–1.14], P = .17) was comparable between both the group of patients, however the incidence of peri device leak was significantly lower in AA group (OR, 0.41 [95% CI: 0.26–0.66], P < .001) compared with WD group of patients.

Conclusion:
The AA was not superior to the Watchman device in terms of safety and efficacy. However, the Amulet occluder was associated with a higher incidence of procedure-related complications, and lower peri device leak.