bluuebunny/crossref_metadata_2025_split huggingface dataset:
On sparsity, power-law, and clustering properties of graphex processes
Authors: Caron François , Panero Francesca , Rousseau Judith 
Published: June 2023

AbstractThis paper investigates properties of the class of graphs based on exchangeable point processes. We provide asymptotic expressions for the number of edges, number of nodes, and degree distributions, identifying four regimes: (i) a dense regime, (ii) a sparse, almost dense regime, (iii) a sparse regime with power-law behaviour, and (iv) an almost extremely sparse regime. We show that, under mild assumptions, both the global and local clustering coefficients converge to constants which may or may not be the same. We also derive a central limit theorem for subgraph counts and for the number of nodes. Finally, we propose a class of models within this framework where one can separately control the latent structure and the global sparsity/power-law properties of the graph.
From Iran to the Netherlands, and everywhere in between
Authors: Ballière Louise 
Published: June 2023

AbstractA migrant's journey is no linear trajectory from A to B. It is a fragmented and complex move over different regions with alternating periods of mobility and immobility. This article researches the complex dynamics of irregular migration from Iran to the Netherlands, and everywhere in between. Through a historical comparison of the life stories of Iranian asylum seekers in the Netherlands in two time periods (1988–1989 and 2009–2010), it studies the routes they took, their relations with human smugglers, and their interactions with immigration policies and border managements along the way. It shows migrants' and smugglers’ flexibility and capacity to adapt to ever-changing circumstances. Migration politics and border controls, along with their increasing limitations on legal migration channels, are indeed crucial in the understanding of irregular migration practices and the ever-growing involvement of facilitating services. Through a combination of this migration policy research and the migration trajectory research, the paper explores these dynamics and the interactions between migrants, smugglers, and state policies in every phase of their journey from Iran to the Netherlands, and everywhere in between.
Identity Matters: Foetuses, Gametes, and Futures like Ours
Authors: Rimell Nicholas 
Published: June 2023

AbstractRecently, a number of philosophers have argued that, despite appearances, the success of Don Marquis's well-known future-like-ours argument against abortion does not turn, in an important way, on the metaphysics of identity. I argue that this is false. The success of Marquis's argument turns on precisely two issues: first, whether it is prima facie seriously wrong to deprive something of a future like ours; second, whether, in a counterfactual circumstance in which an abortion does not occur, the foetus is numerically identical with something that, later on, experiences a life like ours. Since the former claim is plausible (albeit disputable), the success of Marquis's argument does turn on the metaphysics of identity in an important way. Before defending a positive argument for this position, I consider what I take to be the most promising way of challenging it. This involves a recent objection to Marquis by Tim Burkhardt (2021). Burkhardt claims that his objection floats free of the metaphysics of identity. I argue that it fails to do so, and that in fact it fails outright. I end by considering the relationship between my arguments and the question of what matters in survival.
Alternatives to antibiotics in veterinary medicine: considerations for the management of Johne's disease
Authors: O'Connell Laura M. , Coffey Aidan , O'Mahony Jim M. 
Published: June 2023

AbstractAntibiotic resistance has become a major health concern globally, with current predictions expecting deaths related to resistant infections to surpass those of cancer by 2050. Major efforts are being undertaken to develop derivative and novel alternatives to current antibiotic therapies in human medicine. What appears to be lacking however, are similar efforts into researching the application of those alternatives, such as (bacterio)phage therapy, in veterinary contexts. Agriculture is still undoubtedly the most prominent consumer of antibiotics, with up to 70% of annual antibiotic usage attributed to this sector, despite policies to reduce their use in food animals. This not only increases the risk of resistant infections spreading from farm to community but also the risk that animals may acquire species-specific infections that subvert treatment. While these diseases may not directly affect human welfare, they greatly affect the profit margin of industries reliant on livestock due to the cost of treatments and (more frequently) the losses associated with animal death. This means actively combatting animal infection not only benefits animal welfare but also global economies. In particular, targeting recurring or chronic conditions associated with certain livestock has the potential to greatly reduce financial losses. This can be achieved by developing novel diagnostics to quickly identify ill animals alongside the design of novel therapies. To explore this concept further, this review employs Johne's disease, a chronic gastroenteritis condition that affects ruminants, as a case study to exemplify the benefits of rapid diagnostics and effective treatment of chronic disease, with particular regard to the diagnostic and therapeutic potential of phage.
Looking beyond the constituent power theory: The theory of equitable elite bargaining
Authors: Sethi Amal 
Published: June 2023

AbstractThe constituent power theory, which served critical functions for several years, has outlived its utility as the preeminent yardstick to measure the normative legitimacy of a constitution. As the theory stands, it cannot apply on its own terms to most instances of modern constitution-making. At the same time, it is highly susceptible to being used to legitimize authoritarian outcomes. The scholarly literature that attempts to reimagine or expand the theory is scant and unable to overcome its problems. In response, this article develops an alternative standard: the theory of equitable elite bargaining. This theory provides that a constitution is normatively legitimate if it is the product of an equitable bargain between elites from most major political groups in society at the moment of constitution-making. The theory of equitable elite bargaining is applicable to the realities of modern constitution-making and makes it more difficult to legitimize authoritarian constitutions. Further, both representation-based and consequentialist arguments can justify a constitution drafted in accordance with the theory as normatively legitimate. The theory imposes a standard that can result in arduous constitution-making processes and moderated constitutional content. Additionally, its focus on elites poses challenging questions. However, this article will argue that the net benefits of this theory warrant its consideration as a new standard to assess normative constitutional legitimacy.
Role of Mixed Layer Depth in Kuroshio Extension Decadal Variability
Authors: Tozuka Tomoki , Toyoda Takahiro , Cronin Meghan F. 
Published: June 2023

AbstractSea surface temperature (SST) anomalies in the Kuroshio Extension (KE) have been suggested to play a crucial role in decadal climate variability of the North Pacific affecting global climate and marine ecosystem variability. By analyzing the mixed layer heat budget, taking into account seasonality and mixed layer depth (MLD) variations, we here show for the first time that the KE SST front undergoes large decadal variations mainly owing to decadal modulations of the effective heat capacity affecting the SST sensitivity to surface heat fluxes during 1982–2015. More specifically, when the mixed layer becomes anomalously thick (shallow) to the south (north) of the front, it becomes less (more) sensitive to wintertime surface cooling. As a result, the SST front is strengthened, with positive (negative) SST anomalies to the south (north). A heat conservation model suggests that MLD anomalies are mainly due to thermocline depth anomalies.
Evaluation of the Stratospheric Contribution to the Inter‐Annual Variabilities of Tropospheric Methane Growth Rates
Authors: Zhang Peixuan , Zhang Yuzhong , Liang Ruosi , Chen Wei , Xie Xinchun 
Published: June 2023

AbstractTropospheric methane (CH4) shows large inter‐annual variability in its growth rates on top of decadal trends, which is usually interpreted as changes in sources or sinks. The contribution of the stratosphere‐troposphere exchange (STE) is often omitted in such analyses. Here, we quantify annual anomalies of stratosphere‐troposphere CH4 fluxes using varied model‐ or observation‐based methods. Globally, the inter‐annual variability (standard deviation) of this flux during 2000–2020 is 2.0 Tg a−1, producing a variability of ∼0.6 ppb a−1 at the surface, which is only ∼20% of observed surface CH4 growth rate variability. Compared to global averages, high latitudes experience a larger STE‐induced surface variability, which is 80% of the observed surface anomalies in the Antarctic and 44% in the Arctic. Our results suggest that although the STE process is a minor contributor globally, it has a considerable impact over polar regions on the inter‐annual variability of surface CH4 growth rates.
The Thermal Plumbing System of Stromboli Volcano, Aeolian Islands (Italy) Inferred From Electrical Conductivity and Induced Polarization Tomography
Authors: Revil A. , Finizola A. , Johnson T. , Ricci T. , Gresse M. , Delcher E. , Barde‐Cabusson S. , Duvillard P. A. , Ripepe M. 
Published: June 2023

AbstractWe performed the first 3D island‐scale tomography of the electrical conductivity of Stromboli volcano (Aeolian Islands, Italy) using 2D acquisition lines (37.2 km) and a total of 18,880 measurements and 2,402 unique electrode locations. This 3D data set was inverted using a Gauss‐Newton algorithm, parallel‐processing on an unstructured tetrahedral mesh containing 678,420 finite‐element nodes and 3,580,145 elements to account for the topography of the volcanic island. The tomogram exhibits a conductive body (10−2–1.0 S m−1) consistent with the location of CO2 and temperature anomalies observed at the ground surface. It corresponds to the hydrothermal system with high electrical conductivity associated with alteration. In order to confirm this interpretation, a 2.5D large‐scale induced polarization tomography was performed crossing the volcano. The joint interpretation of the conductivity and normalized chargeability is done with a petrophysical model previously tested and verified at both shield‐ and strato‐volcanoes. This model implies that alteration (through the effect of the cation exchange capacity associated with clay minerals and zeolites) plays a strong role in both controlling the electrical conductivity and normalized chargeability at Stromboli volcano. A temperature tomogram, derived from the geoelectrical measurements, is consistent with surface temperature anomalies and the Very Long Period (VLP) seismicity related to the mild‐explosive activity. This survey displays at 600 m a.s.l. a lateral shift in the highest temperature location, also corresponding to the source of VLP seismicity. Structural boundaries have a major role in the hottest hydrothermal fluids rising below the active crater terrace of Stromboli volcano.
Observation and Process Understanding of Typical Cloud Holes Above Lakes Over the Tibetan Plateau
Authors: Yao Xiangnan , Yang Kun , Letu Husi , Zhou Xu , Wang Yan , Ma Xiaogang , Lu Hui , La Zhu 
Published: June 2023

AbstractUnderstanding cloud distribution over lakes is crucial to determine input radiation and precipitation for lake thermal and water balance processes. Based on Himawari‐8 satellite observation and Weather Research and Forecasting model results, this study examines the influences of lakes on daytime cloud cover during warm seasons over the Tibetan Plateau (TP), which is home to thousands of lakes. Observation shows the existence of cloud holes and narrow cloud rings around the lakes, that is, fewer clouds over the lakes and more clouds along the shoreline, which has rarely been reported and is considered typical to TP by comparison with lakes outside of TP. The threshold size of lakes that can produce the shoreline cloud ring is identified to be about 300 km2, as a conservative estimate. We further highlight the importance of atmosphere advection/background wind in the formation of lake‐associated clouds. Lake breeze forms under weak background winds and the downdraft branch inhibits cloud formation over the lakes; while the updraft branch causes convection to form clouds over lakeshores. However, strong background winds do not favor lake breeze formation, changing cloud distribution over the lakes. Fewer clouds are also found in the downwind regions, and this influence is at a distance comparable to the lake scale. Due to fewer clouds over lakes, shortwave radiation is significantly larger (∼100 W/m2) and longwave radiation is smaller (∼a few W/m2) than that of the further land region. Therefore, the above observational facts provide a new perspective to advance the understanding of lake‐air interactions.
Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial
Authors: Hidalgo-Lopez Esmeralda , Engman Jonas , Poromaa Inger Sundström , Gingnell Malin , Pletzer Belinda 
Published: June 2023

AbstractCombined oral contraceptives (COC) are among the most commonly used contraceptive methods worldwide, and mood side effects are the major reason for discontinuation of treatment. We here investigate the directed connectivity patterns associated with the mood side effects of an androgenic COC in a double-blind randomized, placebo-controlled trial in women with a history of affective COC side effects (n = 34). We used spectral dynamic causal modeling on a triple network model consisting of the default mode network (DMN), salience network (SN) and executive control network (ECN). Within this framework, we assessed the treatment-related changes in directed connectivity associated with adverse mood side effects. Overall, during COC use, we found a pattern of enhanced connectivity within the DMN and decreased connectivity within the ECN. The dorsal anterior cingulate cortex (SN) mediates an increased recruitment of the DMN by the ECN during treatment. Mood lability was the most prominent COC-induced symptom and also arose as the side effect most consistently related to connectivity changes. Connections that were related to increased mood lability showed increased connectivity during COC treatment, while connections that were related to decreased mood lability showed decreased connectivity during COC treatment. Among these, the connections with the highest effect size could also predict the participants’ treatment group above chance.
Androgen dihydrotestosterone promotes bladder cancer cell proliferation and invasion via EPPK1-mediated MAPK/JUP signalling
Authors: Yang Long , Huang Wen , Bai Xiaoyu , Wang Haoyu , Wang Xiaolei , Xiao Huiyuan , Li Yanlei 
Published: June 2023

AbstractThe incidence of bladder cancer (BLCA) in men is higher than that in women. Differences in androgen levels between men and women are considered the main causes of incidence rate differences. In this study, dihydrotestosterone (DHT) significantly increased the proliferation and invasion of BLCA cells. In addition, BLCA formation and metastatic rates were higher in N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-treated male mice than in female and castrated male mice in vivo. However, immunohistochemistry showed that androgen receptor (AR) was expressed at low levels in normal and BLCA tissues of men and women. The classical AR pathway considers that DHT binds to AR and induces it to enter the nucleus, where it functions as a transcription factor. Here, a non-AR combination pathway of androgen that promoted BLCA development was investigated. The EPPK1 protein was bombarded with DHT, as determined by biotinylated DHT-binding pull-down experiments. EPPK1 was highly expressed in BLCA tissues, and EPPK1 knockdown significantly inhibited BLCA cell proliferation and invasion promoted by DHT. Moreover, JUP expression was elevated in DHT-treated high-EPPK1 expressing cells, and JUP knockdown inhibited cell proliferation and invasion. EPPK1 overexpression increased tumour growth and JUP expression in nude mice. Furthermore, DHT increased the expression of the MAPK signals p38, p-p38, and c-Jun, and c-Jun could bind to the JUP promoter. However, the promotion of p38, p-p38, and c-Jun expression by DHT was not observed in EPPK1 knockdown cells, and a p38 inhibitor suppressed the DHT-induced effects, indicating that p38 MAPK may be involved in the regulation of DHT-dependent EPPK1-JUP-promoted BLCA cell proliferation and invasion. The growth of bladder tumours in BBN-treated mice was inhibited by the addition of the hormone inhibitor goserelin. Our findings indicated the potential oncogenic role and mechanism of DHT in BLCA pathogenesis through a non-AR pathway, which may serve as a novel therapeutic target for BLCA.
Electric double layer-mediated polarization field for optimizing photogenerated carrier dynamics and thermodynamics
Authors: Zhou Chengxin , Gao Jian , Deng Yunlong , Wang Ming , Li Dan , Xia Chuan 
Published: June 2023

AbstractPhotocatalytic hydrogen evolution efficiency is limited due to unfavorable carrier dynamics and thermodynamic performance. Here, we propose to introduce electronegative molecules to build an electric double layer (EDL) to generate a polarization field instead of the traditional built-in electric field to improve carrier dynamics, and optimize the thermodynamics by regulating the chemical coordination of surface atoms. Based on theoretical simulation, we designed CuNi@EDL and applied it as the cocatalyst of semiconductor photocatalysts, finally achieved a hydrogen evolution rate of 249.6 mmol h−1g−1and remained stable after storing under environmental conditions for more than 300 days. The high H2yield is mainly due to the perfect work function, Fermi level and Gibbs free energy of hydrogen adsorption, improved light absorption ability, enhanced electron transfer dynamics, decreased HER overpotential and effective carrier transfer channel arose by EDL. Here, our work opens up new perspectives for the design and optimization of photosystems.
Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics
Authors: Kikuchi Hiroaki , Chou Chung-Lin , Yang Chin-Rang , Chen Lihe , Jung Hyun Jun , Park Euijung , Limbutara Kavee , Carter Benjamin , Yang Zhi-Hong , Kun Julia F. , Remaley Alan T. , Knepper Mark A. 
Published: June 2023

AbstractLoss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy.
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2
Authors: Gaynor Katherine U. , Vaysburd Marina , Harman Maximilian A. J. , Albecka Anna , Jeffrey Phillip , Beswick Paul , Papa Guido , Chen Liuhong , Mallery Donna , McGuinness Brian , Van Rietschoten Katerine , Stanway Steven , Brear Paul , Lulla Aleksei , Ciazynska Katarzyna , Chang Veronica T. , Sharp Jo , Neary Megan , Box Helen , Herriott Jo , Kijak Edyta , Tatham Lee , Bentley Eleanor G. , Sharma Parul , Kirby Adam , Han Ximeng , Stewart James P. , Owen Andrew , Briggs John A. G. , Hyvönen Marko , Skynner Michael J. , James Leo C. 
Published: June 2023

AbstractCOVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both. Bicycles are entropically constrained peptides stabilized by a central chemical scaffold into a bi-cyclic structure. Rapid screening of diverse bacteriophage libraries against SARS-CoV-2 Spike yielded unique Bicycle binders across the entire protein. Exploiting Bicycles’ inherent chemical combinability, we converted early micromolar hits into nanomolar viral inhibitors through simple multimerization. We also show how combining Bicycles against different epitopes into a single biparatopic agent allows Spike from diverse variants of concern (VoC) to be targeted (Alpha, Beta, Delta and Omicron). Finally, we demonstrate in both male hACE2-transgenic mice and Syrian golden hamsters that both multimerized and biparatopic Bicycles reduce viraemia and prevent host inflammation. These results introduce Bicycles as a potential antiviral modality to tackle new and rapidly evolving viruses.
Pen-drawn Marangoni swimmer
Authors: Song Seo Woo , Lee Sumin , Choe Jun Kyu , Lee Amos Chungwon , Shin Kyoungseob , Kang Junwon , Kim Gyeongjun , Yeom Huiran , Choi Yeongjae , Kwon Sunghoon , Kim Jiyun 
Published: June 2023

AbstractPen-drawing is an intuitive, convenient, and creative fabrication method for delivering emergent and adaptive design to real devices. To demonstrate the application of pen-drawing to robot construction, we developed pen-drawn Marangoni swimmers that perform complex programmed tasks using a simple and accessible manufacturing process. By simply drawing on substrates using ink-based Marangoni fuel, the swimmers demonstrate advanced robotic motions such as polygon and star-shaped trajectories, and navigate through maze. The versatility of pen-drawing allows the integration of the swimmers with time-varying substrates, enabling multi-step motion tasks such as cargo delivery and return to the original place. We believe that our pen-based approach will significantly expand the potential applications of miniaturized swimming robots and provide new opportunities for simple robotic implementations.
Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions
Authors: Alfieri Fabio , Caravagna Giulio , Schaefer Martin H. 
Published: June 2023

AbstractCancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious, almost all protein-coding genes lack detectable signals of negative selection. This raises the question of how tumors tolerate such large amounts of deleterious mutations. Using 8,690 tumor samples from The Cancer Genome Atlas, we demonstrate that copy number amplifications frequently cover haploinsufficient genes in mutation-prone regions. This could increase tolerance towards the deleterious impact of mutations by creating safe copies of wild-type regions and, hence, protecting the genes therein. Our findings demonstrate that these potential buffering events are highly influenced by gene functions, essentiality, and mutation impact and that they occur early during tumor evolution. We show how cancer type-specific mutation landscapes drive copy number alteration patterns across cancer types. Ultimately, our work paves the way for the detection of novel cancer vulnerabilities by revealing genes that fall within amplifications likely selected during evolution to mitigate the effect of mutations.