bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Environmental Support on Health for Children with Hearing Impairment in Taiwan
Authors: Lin Chung-Ying , Fung Xavier C. C. 
Published: February 2025

Introduction:
Children with hearing impairment (HI) often encounter difficulties in learning due to their language problems caused by HI. Therefore, children with HI also suffer from health problems, including psychological health, social relationship, and school performance. Given that the International Classification of Function, Disability, and Health proposed environment as a key element in promoting health. This study proposed to investigate the impacts of environmental support on health and learning abilities among a nationally representative sample with HI.

Methods:
A total of 163 children (94 boys; 88 first graders and 75 third graders) retrieved from the Special Needs Education Longitudinal Study were used for analysis. Questionnaire items on environmental support (3 items), impairment (1 item), learning ability (4 items), and health (4 items) were constructed in a structural equation model. Specifically, environmental support was linked to impairment, learning ability, and health; impairment was linked to learning ability and health.

Results:
Our results indicated that environmental support had positive effects on three dimensions of health (social relationship, β = 0.38; emotional functioning, β = 0.27; and school performance, β = 0.59) and learning ability (β = 0.26); negative effects on impairment (β = −0.62). Impairment had negative impacts on two dimensions of health (physical fitness and school performance, β = −0.18 and −0.22, respectively) and learning ability (β = −0.29).

Conclusions:
According to our findings, health-care professionals and school teachers may consider establishing good environmental support for children with HI. Thus, children with HI may have improved health and learning abilities.
Job Stress, Sexual Harassment, Self-Harm Behavior, and Suicidal Ideation Among Military Personnel in Taiwan
Authors: Jin Huei-Ting , Lin Yi-Ching , Strong Carol 
Published: February 2025

Introduction:
The aim of this study was first to estimate the prevalence of having self-harm behavior and suicidal ideation in a sample of military personnel. Second, we examined whether work stress, sexual harassment experiences, and depression were associated with suicidal ideation and self-harm behavior.

Methods:
A cross-sectional survey was conducted in Taiwan between January and April 2016. Sample was recruited from large military bases in Taiwan, including army, navy, and air force using convenience sampling. Self-reported data on job stress, sexual harassment experiences, self-harm behavior, and suicidal ideation were collected. Multiple logistic regression was used to determine the risk factors associated with having had self-harm behavior or suicidal ideation.

Results:
Of 513 individuals surveyed, 4.5% had self-harm behavior in the past 12 months and 9% had considered suicide. The majority of the sample were male (81.9%), between 20 and 29 years old (87.7%), voluntary military service (79.7%), and single or not married (90.8%). A higher level of sexual harassment experiences, higher level of perceived work stress, interpersonal relationship, and a lower level of job satisfaction were associated with self-harm behaviors. In multivariate analysis, gender, education, perceived work stress, sexual harassment, and depression were significantly associated with having had considered suicide in the past 12 months.

Discussion:
Our study highlighted the importance of acknowledging the vulnerability of the military work environment, including self-harming tendencies and sexual harassment. Education and training to ensure gender equality should be provided through appropriate channels.
Effect of forearm and posterior wall anastomosis on gastroesophageal reflux in proximal gastrectomy patients
Authors: Yang Jia-Le , Yang Yi-Jie , Xu Lu 
Published: February 2025

BACKGROUND
Proximal gastrectomy for gastric cancer often leads to postoperative gastroesophageal reflux (GER). This study compares the impact of forearm anastomosis and posterior wall anastomosis techniques on GER in patients undergoing this procedure.
AIM
To identify the most effective method for reducing reflux symptoms while preserving gastrointestinal integrity and nutritional status.
METHODS
A retrospective evaluation was conducted on 60 patients who underwent proximal gastrectomy between December 2020 and December 2023, divided equally into two groups based on the anastomosis technique used (forearm or posterior wall). GER symptoms were assessed using the GER disease questionnaire (GerdQ) preoperatively and on the first postoperative day. Biochemical markers [diamine oxidase (DAO), D-lactic acid, and endotoxin (ETX)] and nutritional indicators [serum ferritin (SF), prealbumin (PA), and albumin (ALB)] were measured to evaluate gastrointestinal barrier function and nutritional status.
RESULTS
Both groups showed significant improvements in GerdQ scores and reflux symptom scores post-treatment, with the observation group exhibiting greater reductions. Biochemical markers indicated enhanced gastrointestinal barrier function post-treatment in both groups, with notable increases in DAO, D-lactic, and ETX levels. Nutritional status indicators also demonstrated significant changes, with reductions in SF, PA, and ALB levels, suggesting an impact of treatment on inflammatory and nutritional status.
CONCLUSION
The forearm anastomosis technique appears to be more effective in reducing GER symptoms and preserving gastrointestinal health in patients undergoing proximal gastrectomy for gastric cancer compared to the posterior wall anastomosis technique. These preliminary findings advocate for further research to confirm the benefits and potentially standardize Forearm Anastomosis in surgical practice for gastric cancer.
Clinical effect and prognosis of laparoscopic surgery on colon cancer complicated with intestinal obstruction patients
Authors: Wu Pei-Hua , Ta Zheng-Quan 
Published: February 2025

BACKGROUND
Colon cancer is one of the most common malignancies of the digestive tract, often complicated by intestinal obstruction, which can significantly impact patient outcomes. While traditional laparotomy is the standard treatment, it is associated with large wounds, slower recovery, and higher complication rates. Laparoscopic surgery, a minimally invasive approach, may offer better outcomes for these patients.
AIM
To evaluate the clinical effects and prognosis of laparoscopic surgery in patients with colon cancer complicated by intestinal obstruction compared to traditional laparotomy.
METHODS
A retrospective analysis was conducted on 100 patients diagnosed with colon cancer and intestinal obstruction who underwent surgical treatment between January 2020 and December 2022. Patients were divided into two groups: The control group (CG), treated with traditional laparotomy, and the observation group (OG), treated with laparoscopic surgery. Clinical effects, surgical indicators, postoperative pain, inflammatory response, complication rates, quality of life, and prognosis were assessed and compared between the two groups.
RESULTS
The OG showed superior clinical outcomes compared to the CG (P < 0.05). Patients in the OG had shorter operation times, reduced intraoperative blood loss, faster recovery of intestinal function, earlier mobilization, and shorter hospital stays (P < 0.05). Postoperative pain (numerical rating scale scores) and inflammatory markers [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP)] were lower in the OG (P < 0.05). The incidence of complications was significantly reduced in the OG (6.00% vs 22.00%, P < 0.05). Quality of life scores, including physical function, psychological state, social communication, and self-care ability, were significantly higher in the OG (P < 0.05). There were no significant differences between groups in abdominal drainage volume, 1-year tumor recurrence or metastasis rates, or 1- and 3-year survival rates (P > 0.05).
CONCLUSION
The OG showed superior clinical outcomes compared to the CG (P < 0.05). Patients in the OG had shorter operation times, reduced intraoperative blood loss, faster recovery of intestinal function, earlier mobilization, and shorter hospital stays (P < 0.05). Postoperative pain (NRS scores) and inflammatory markers (TNF-α, IL-6, CRP) were lower in the OG (P < 0.05). The incidence of complications was significantly reduced in the OG (6.00% vs 22.00%, P < 0.05). Quality of life scores, including physical function, psychological state, social communication, and self-care ability, were significantly higher in the OG (P < 0.05). There were no significant differences between groups in abdominal drainage volume, 1-year tumor recurrence or metastasis rates, or 1- and 3-year survival rates (P > 0.05).
High cellular prion protein expression in cholangiocarcinoma: A marker for early postoperative recurrence and unfavorable prognosis
Authors: Shin Dong Woo , Cho Yoon Ah , Moon Sung-Hoon , Kim Tae Hyung , Park Ji-Won , Lee Jung-Woo , Choe Ji-Young , Kim Min-Jeong , Kim Sung-Eun 
Published: February 2025

BACKGROUND
The cellular prion protein (PrPC), traditionally associated with neurodegenerative disorders, plays an important role in cancer progression and metastasis by inhibiting apoptosis.
AIM
To investigate the influence of PrPC expression in cholangiocarcinoma (CCA) on patient outcomes following surgical resection.
METHODS
Patients who underwent curative surgical resection for either intrahepatic or hilar CCA were enrolled in this retrospective study. Based on the immunohistochemical staining results of the surgical specimens, patients were categorized into two groups: The low PrPC group (negative or 1+) and the high PrPC group (2+ or 3+). Survival analyses, including overall survival and recurrence-free survival, were conducted using the Kaplan-Meier method and compared using the log-rank test.
RESULTS
In total, seventy-six patients diagnosed with CCA (39 with intrahepatic and 37 with hilar CCA) underwent curative hepatectomy from January 2011 to November 2021. Among these patients, 38 (50%) demonstrated high PrPC expression, whereas the remaining 38 (50%) showed low expression of PrPC. During a median follow-up period of 31.2 months (range: 1 to 137 months), the high PrPC group had a significantly shorter median overall survival than the low PrPC group (40.4 months vs 137.9 months, respectively; P = 0.041). Moreover, the high PrPC group had a significantly shorter median recurrence-free survival than the low PrPC group (13.3 months vs 23.8 months, respectively; P = 0.026).
CONCLUSION
PrPC expression is significantly associated with early recurrence and decreased survival period in CCA patients following surgical resection. Thus, PrPC may be used as a prognostic factor in treatment planning.
Patient selection and operative strategies for laparoscopic intersphincteric resection without diverting stoma
Authors: Hu Gang , Ma Ji , Qiu Wen-Long , Mei Shi-Wen , Zhuang Meng , Xue Jun , Liu Jun-Guang , Tang Jian-Qiang 
Published: February 2025

BACKGROUND
Diverting stoma (DS) is routinely proposed in intersphincteric resection for ultralow rectal cancer, but it is associated with increased stoma-related complications and economic burden. Appropriate patient selection and operative strategies to avoid stoma formation need further elucidation.
AIM
To select patients who may not require DS.
METHODS
This study enrolled 505 consecutive patients, including 84 who underwent stoma-free (SF) intersphincteric resection. After matching, patients were divided into SF (n = 78) and DS (n = 78) groups. The primary endpoint was the anastomotic leakage (AL) rate within 6 months and its protective factors for both the total and SF cohorts. The secondary endpoints included overall survival and disease-free survival.
RESULTS
The AL rate was greater in the SF group than in the DS group (12.8% vs 2.6%, P = 0.035). Male sex [(odds ratio (OR) = 2.644, P = 0.021], neoadjuvant chemoradiotherapy (nCRT) (OR = 6.024, P < 0.001), and tumor height from the anal verge ≤ 4 cm (OR = 4.160, P = 0.007) were identified as independent risk factors. Preservation of the left colic artery (LCA) was protective in both the total cohort (OR = 0.417, P = 0.013) and the SF cohort (OR = 0.312, P = 0.027). The female patients who did not undergo nCRT and had preservation of the LCA experienced a significantly lower incidence of AL (2/97, 2.1%). The 3-year overall survival or disease-free survival did not significantly differ between the groups.
CONCLUSION
Female patients who do not receive nCRT may avoid the need for DS by preserving the LCA without increasing the risk of AL or compromising oncological outcomes.
Systematic review and meta-analysis comparing extraperitoneal and transperitoneal routes of colostomy-related complications
Authors: Isah Adamu D , Wang Xu , Shaibu Zakari , Yuan Xiao , Dang Sheng-Chun 
Published: February 2025

BACKGROUND
Complications associated with stomas—including parastomal hernia (PSH), prolapse, mucocutaneous separation, and stoma retraction—provide considerable postoperative challenges for colostomy patients. Selecting between extraperitoneal colostomy (EPC) and transperitoneal colostomy (TPC) pathways is therefore essential for mitigating these complications.
AIM
To analyze the existing data regarding the efficacy of EPC compared to TPC in reducing stoma-related complications post-colostomy.
METHODS
PubMed, Google Scholar, EMBASE, MEDLINE, and the Cochrane Library were adopted to uncover pertinent papers in which EPC and TPC approaches were compared. We then conducted a meta-analysis using RevMan 5.4.1.
RESULTS
Both laparoscopic (Lap) and open approaches showed a reduced incidence of PSH in EPC relative to TPC (P < 0.00001 and P = 0.02 respectively). In addition, Lap EPC depicted a lesser incidence of prolapse, mucocutaneous separation, and stoma retraction (P = 0.007, P = 0.03, and P = 0.01, respectively) compared to Lap TPC. However, EPC and TPC did not differ with respect to operation time, blood loss, edema, ischemia, necrosis, or infection after the LAP approach.
CONCLUSION
The extraperitoneal approach may provide benefits in minimizing some stoma-related problems such as PSH, prolapse, mucocutaneous separation, and stoma retraction after colostomy surgery.
Preparation and evalution of sustained release matrix tablet of nitrofurantoin
Authors: Arora Harpreet Singh , Kaur Taranjit , Kumar Rajesh , Singh Amar Pal , Singh Singh 
Published: February 2025

In the present study an attempt was made to Preparation and Evaluation of Sustained Release Matrix Tablet of Nitrofurantoin by wet granulation method using various polymers like HPMC 4000 & PVPK 30

Materials and Methods
A variety of physicochemical characteristics, including rheological characteristics, weight variation, thickness, hardness, in vitro release studies, and drug content, were assessed for the prepared tablets.

Results
All of the physicochemical parameters met the official standards, according to studies. The extended release profile of the formulation, which has better bioavailability and lower dosing frequency with lower doses, is confirmed by the in vitro release studies, which show release up to 90.02 % over an extended period of time.

Conclusion
Nitrofurantoin sustained release matrix tablets have shown improved potency, efficacy, and bioavailability. According to the drug release study, PVPK 30 and HPMC4000 could maintain the drug release. The drug release was sustained for over twenty-four hours when both polymers were combined with the drug.
STRATEGI MENINGKATKAN PEMAHAMAN VISUALISASI SISWA MELALUI BUKU POP-UP SERI FISIOLOGI DAN ANATOMI MANUSIA
Authors: Yuliawati Yuliawati , Utami Diah Tri , Elisma Elisma 
Published: February 2025

The attainment of learning competencies is contingent on the quality of the offered material and the utilized learning media. Pop-up books function as captivating instructional instruments, incorporating three-dimensional elements that facilitate movement and enrich the visuals on each page. Human Anatomy and Physiology courses constitute a vital element of health education and typically necessitate appealing graphic illustrations. This study seeks to examine the impact of pop-up books on student comprehension. This research design employs a pure experimental methodology with a one-group pretest-posttest framework. The research sample comprised students from the Pharmacy Study Program at the Faculty of Medicine and Health Sciences, Jambi University, for the academic year 2020/2021. The investigated data consists of test results obtained before and after utilizing the pop-up book. The aggregate of all scores divided by the student count yields the class average. This average value determines the overall capability of the class. Subsequently, ascertain the number of students who have not met the learning success target and the percentage of those who have attained it. The research findings indicate that pop-up book media can effectively enhance student performance in Human Anatomy and Physiology courses.
ABSTRAKKetercapaian kompetensi pembelajaran tidak hanya bergantung pada kualitas materi yang disampaikan, tetapi juga pada media pembelajaran yang digunakan. Buku pop-up berfungsi sebagai alat pendidikan yang menarik, menampilkan komponen tiga dimensi yang dapat memberikan gerakan dan meningkatkan citra pada setiap halaman. Mata kuliah Anatomi dan Fisiologi Manusia merupakan komponen penting dari pendidikan kesehatan dan biasanya memerlukan representasi grafis yang menarik. Penelitian ini bertujuan untuk menganalisis pengaruh buku pop-up terhadap pemahaman mahasiswa. Desain penelitian ini menggunakan metodologi eksperimental murni dengan kerangka one-group pretest-posttest. Sampel penelitian yaitu mahasiswa Program Studi Farmasi Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi, tahun akademik 2020/2021. Data yang dianalisis yaitu hasil tes yang telah diikuti sebelum dan setelah penggunaan buku pop-up. Jumlah seluruh nilai dibagi dengan jumlah mahasiswa menghasilkan rata-rata kelas. Kemampuan umum kelas dipastikan menggunakan nilai rata-rata ini. Kemudian ditentukan banyaknya mahasiswa yang belum mencapai target keberhasilan belajar dan persentase mahasiswa yang mencapainya. Hasil penelitian menunjukkan bahwa media buku pop-up dapat digunakan sebagai media pembelajaran untuk meningkatkan prestasi belajar mahasiswa dalam proses pembelajaran mata kuliah Anatomi dan Fisiologi Manusia.
REFLEKSI GANDENG GENDONG MODEL PEMBERDAYAAN MASYARAKAT DI KOTA YOGYAKARTA
Authors: Muryani Luluk , Sugiyanto Sugiyanto 
Published: February 2025

Poverty and income inequality in the community are strategic issues for the Yogyakarta City Government. One of the reasons is the low competitiveness of small businesses and the lack of strong synergy between poverty alleviation programs and activities. This encouraged the initiation of the Gandeng Gendong program innovation, namely a collaboration program between development stakeholders. To realize Gandeng Gendong's innovation, it is necessary to strengthen the role of stakeholders, namely cities, corporations, campuses, communities and villages, which is acronymed with the term 5K. Strong stakeholders will have a positive impact on the success of the tandem carrying program. Qualitative descriptive research approach. Informants were selected according to purposive sampling technique. Data collection techniques using interview, observation and documentation methods. Primary and secondary data are integrated into content analysis and then tested using triangulation techniques. The research results show that the collaboration program has had a positive impact in reducing poverty rates. From 2019 to 2023, the poverty rate experienced a downward trend, namely 0.86%. Apart from that, the level of participation of people who are members of the gangen gendong program, especially in the nlarisi application, is increasing. However, several obstacles were still found, namely that assistance from authorized Regional Apparatus Organizations was felt to be insufficient.
ABSTRAKKemiskinan dan ketimpangan pendapatan masyarakat adalah isu strategis Pemerintah Kota Yogyakarta. Salah satu penyebabnya adalah masih rendahnya daya saing pelaku usaha kecil serta belum adanya sinergi yang kuat keterpaduan antar program dan kegiatan pengentasan kemiskinan. Hal ini mendorong dicetuskannya inovasi program Gandeng Gendong, yaitu program kerjasama antar stakeholder pembangunan. Untuk mewujudkan inovasi Gandeng Gendong, perlu penguatan peran stakeholder, yaitu kota, korporasi, kampus, kamunitas dan kampung yang diakronim dengan istilah 5K. Stakeholder Peran dan kerjasama yang kuat antar pemangku kepentingan pembangunan tersebut akan membawa dampak positif atas keberhasilan program gandeng gendong. Pendekatan penelitian deskriptif kualitatif. Informan dipilih sesuai teknik purposive sampling. Teknik pengumpulan data dengan metode wawancara, observasi, dan dokumentasi. Data primer dan dan sekunder diintegrasikan dalam konten analisis kemudian diuji dengan teknik triangulasi. Hasil penelitian menunjukkan bahwa program gandeng memberikan dampak positif dalam penurunan angka kemiskinan. Sejak tahun 2019 sampai dengan tahun 2023, jumlah angka kemiskinan mengalami tren penurunan, yaitu 0,86%. Selain itu, tingkat partisipasi masyarakat yang tergabung dalam program gandeng gendong, khususnya dalam aplikasi nglarisi semakin bertambah. Namun masih ditemukan beberapa kendala yaitu pendampingan dari Organisasi Perangkat Daerah yang berwenang dirasakan belum cukup.
A global monthly 3D field of seawater pH over 3 decades: a machine learning approach
Authors: Zhong Guorong , Li Xuegang , Song Jinming , Qu Baoxiao , Wang Fan , Wang Yanjun , Zhang Bin , Cheng Lijing , Ma Jun , Yuan Huamao , Duan Liqin , Li Ning , Wang Qidong , Xing Jianwei , Dai Jiajia 
Published: February 2025

Abstract. The continuous uptake of anthropogenic CO2 by the ocean leads to ocean acidification, which is an ongoing threat to marine ecosystem. The ocean acidification rate has been globally documented in the surface ocean, but this information is limited below the surface. Here, we present a monthly 4D 1°×1° gridded product of global seawater pH on the total scale and at in situ temperature (without standardization to 25 °C), derived from a machine learning algorithm trained on pH observations from the Global Ocean Data Analysis Project (GLODAP). The proposed pH product covers the years from 1992 to 2020 and depths from the surface to 2 km on 41 levels. A three-step machine-learning-based algorithm was used to construct the pH product, incorporating region division via a self-organizing map neural network, predictor selection via the stepwise regression algorithm that adds and removes variables from network inputs based on their contribution to reducing reconstruction errors, and nonlinear relationship regression by feedforward neural networks (FFNNs). The performance of the machine learning algorithm was validated using real observations with a cross-validation method, in which four repeating iterations were carried out with each iteration utilizing a different 25 % subset of observations for validation and the complementary 75 % subset for training. The proposed pH product is evaluated using comparisons to time-series observations and the GLODAP pH climatology. The overall root-mean-square error between the FFNN-reconstructed pH and the GLODAP measurements is 0.028, ranging from 0.044 at the surface to 0.013 at 2000 m. The pH product is distributed via the Marine Science Data Center of the Chinese Academy of Sciences: https://doi.org/10.12157/IOCAS.20230720.001 (Zhong et al., 2023).