bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using a virtual reality power mobility device simulator to assess the driving skills of people with brain diseases
Authors: Kwon Namwoo , Lim Myung Joon , Hong Ilki , Kim Hyoung Seop 
Published: June 2023

Introduction No previous study has explored the effectiveness of current prescription standards for evaluating power mobility device (PMD) maneuverability. To verify the current prescription standards for PMDs using a virtual reality (VR)-based PMD simulator and to present the possibility of using a VR-based PMD simulator as an alternative to current evaluation standards. Methods A total of 52 patients with brain diseases were enrolled. All participants were over 18 years old and had gait disturbance or limited outdoor walking ability. Participants performed a driving ability test using a VR PMD simulator. Results The driving ability test using the VR PMD simulator indicated that cognitive impairment, measured by the K-MMSE ( p = 0.017), and unilateral neglect, measured by line bisection ( p = 0.031), led to reduced driving ability and safety. In addition, patients with cognitive impairment or neglect presented driving stability problems, which were observed in the driving trajectory. There was also no correlation between driving scores and MBI subitems. Conclusion In patients with brain lesions, a driving ability test using a VR PMD simulator can be a safe, objective method for comprehensively evaluating a driver’s capacity, offering an alternative to the current prescription standards for PMDs.
Factors Associated With COVID-19 Vaccine Acceptance Among Patients Receiving Care at a Federally Qualified Health Center
Authors: Lalika Mathias , Woods Cynthia , Patel Aarti , Scott Christopher , Lee Alexander , Weis Jennifer , Jones Clarence , Abbenyi Adeline , Brockman Tabetha A. , Sia Irene G. , White Richard O. , Doubeni Chyke A. , Brewer LaPrincess C. 
Published: June 2023

Background: COVID-19 vaccine hesitancy in the United States is high, with at least 63 million unvaccinated individuals to date. Socioeconomically disadvantaged populations experience lower COVID-19 vaccination rates despite facing a disproportionate COVID-19 burden. Objective: To assess the factors associated with COVID-19 vaccine acceptance among under-resourced, adult patients. Methods: Participants were patients receiving care at a Federally Qualified Health Center (FQHC) in St. Paul, Minnesota. Data were collected via multiple modes over 2 phases in 2020 (self-administered electronic survey) and 2021 (study team-administered survey by telephone, self-administered written survey) to promote diversity and inclusion for study participation. The primary outcome was COVID-19 vaccine acceptance. Using logistic regression analysis, associations between vaccine acceptance and factors including risk perception, concerns about the COVID-19 vaccine, social determinants of health (SDOH), co-morbidities, pandemic-induced hardships, and stress were assessed by adjusted odds ratios (AORs) and 95% confidence intervals (CI). Results: One hundred sixty-eight patients (62.5% female; mean age [SD]: 49.9 [17.4] years; 32% <$20 000 annual household income; 69% <college education) were included in the study. Sixty-one percent of the patients received or were willing to receive the vaccine. Risk perception was positively associated with vaccine acceptance (AOR: 5.3; 95% CI: 2.5, 11.5, P < .001), while concerns about the vaccine (eg, safety, side effects, rapid development of the vaccine, etc.) were negatively associated with vaccine acceptance (all P < .001). SDOH, co-morbidities, pandemic-induced hardships were not associated with vaccine acceptance. Conclusions: Our study in a socioeconomically disadvantaged population suggests that risk perception is associated with an increased likelihood of vaccine acceptance, while concerns about the COVID-19 vaccine are associated with a lower likelihood of vaccine acceptance. As these factors could impact vaccine uptake, consistent, innovative, and context-specific risk communication strategies may improve vaccine coverage in this population.
Factors affecting shift work sleep disorder in female shift work nurses: Integrating shift workers’ coping with stress and transactional stress coping theory
Authors: Setyowati Anggi , Yusuf Ah. , Agianto  , Yunitasari Esti , Firdaus Syamsul 
Published: June 2023

Background: Nurses have to work different and often irregular shifts to provide care. This puts nurses at health risks, such as sleep impairment. Design and methods: The aim of this study was to test the comprehensive conceptual framework for predicting shift work sleep disorder of female nurses, we used a structural equation model analysis based on shift worker’s coping and transactional stress coping theory. This study used a cross-sectional design. We collected the data from three public hospitals and three private hospitals in South Kalimantan, Indonesia, with a total sample of 201 female shift work nurses. Data were collected from February to April 2020. We were also granted permission by the director and the head nurse of these hospitals. After obtaining the informed consent forms, we distributed the online self-report questionnaire using Google Forms. Demographic data were evaluated using descriptive statistical analysis. We used a structural equation model analysis to test the comprehensive conceptual framework for predicting shift work sleep disorder of female shift work nurses. Results: The model’s effectiveness in predicting factors contributing to shift work sleep disorder was confirmed by the good statistical fit indicated by the comparative fit index, root-mean-square error of approximation, incremental fit index, and Tucker Lewis Index. Conclusions: This study provides evidences that workload and interpersonal conflict contribute to occupational stress. Workload, interpersonal conflict, and the biological sleep clock influences shift work sleep disorder through mediators of coping strategies and stress.
Efficacy of ozonated water as a PS in photodynamic therapy: A tool for dental caries management? An in vitro study
Authors: Casu Cinzia , Orrù Germano , Fais Sara , Mazur Marta , Grassi Roberta , Grassi Roberto Felice , Nardi Gianna Maria 
Published: June 2023

Background: The most prevalent noncommunicable disease in the world is dental caries; and when it is not adequately treated, it is usually associated with tooth loss or severe dental lesions. In fact, expensive care or tooth extraction may be necessary due to the negative effects dental caries have on general health. This is due to its frequent pain and secondary bacterial infections. The aim of this study was to investigate the activity of ozonated water as such and in combination with appropriate light radiation so as to perform a photodynamic treatment (PDT) against the cariogenic bacterium Streptococcus mutans. Design and methods: This work has been performed in vitro by using an S. mutans strain mainly structured in a biofilm status, reproducing the natural condition of the tooth infection. The ozone was tested at three different concentrations by using a commercial device able to generate different O3 formulations in water. The PDT treatment requires an appropriate light wavelength, evaluated in this work through the UV-Vis adsorption spectrum of the ozonated water. Results: The obtained results suggested an effective and synergic property of O3 and light at 460–470 nm against this microorganism. The most antibiofilm activity was observed using a concentration of ozone of 0.06 mg/L alone as well as with PDT treatment. Conclusions: The results are encouraging for additional research and in vitro/in vivo fresh experimental investigations to perform an exhaustive antimicrobial treatment protocol against the S. mutans tooth infection.
Prediction of response to thrombolysis in acute stroke using neural network analysis of CT perfusion imaging
Authors: Chen Yutong , Tozer Daniel J , Liu Weiran , Peake Edward J , Markus Hugh S 
Published: June 2023

Background: In ischaemic stroke patients undergoing reperfusion therapy, the amount of salvageable tissue, that is, extent of the ischaemic penumbra, predicts the clinical outcomes. CT perfusion (CTP) enables quantification of penumbral tissues to guide decision making, and current programmes have automated its analysis. More advanced machine learning techniques utilising the CTP maps may improve prediction beyond the ischaemic volume measures. Method: We determined whether applying convolutional neural networks (CNN), a key machine learning technique in modelling image-label relationships, to post-processed CTP maps improved prediction of outcome, assessed by 3 months modified Rankin scale (mRS). Patients who underwent thrombolysis but not thrombectomy were included. CTP maps of a retrospective cohort of 230 patients with middle cerebral artery stroke were used to develop the model, which was validated in an independent cohort of 129 patients. Results: We constructed a CNN model that predicted a favourable post-thrombolysis outcome (mRS 0–2 at 3 months) with an area under receiver-operator characteristics curve (AUC) of 0.792 (95% CI, 0.707–0.877). This model outperformed a currently clinically used MISTAR software using previously validated thresholds (AUC = 0.583, 95% CI, 0.480–0.686) and a model modified using thresholds from the derivation cohort (AUC = 0.670, 95% CI, 0.571–0.769). By combining CNN-derived features and baseline demographic features, the prediction AUC was improved to 0.865 (95% CI, 0.794–0.936). Conclusion: CNN improved prediction of post-thrombolysis outcome, and may be useful in selecting which patients benefit from thrombolysis.
The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution
Authors: Doty Raymond T. , Lausted Christopher G. , Munday Adam D. , Yang Zhantao , Yan Xiaowei , Meng Changting , Tian Qiang , Abkowitz Janis L. 
Published: June 2023

AbstractThe anemias of myelodysplastic syndrome (MDS) and Diamond Blackfan anemia (DBA) are generally macrocytic and always reflect ineffective erythropoiesis yet result from diverse genetic mutations. To delineate shared mechanisms that lead to cell death, we studied the fate of single erythroid marrow cells from individuals with DBA or MDS-5q. We defined an unhealthy (vs healthy) differentiation trajectory using transcriptional pseudotime and cell surface proteins. The pseudotime trajectories diverge immediately after cells upregulate transferrin receptor (CD71), import iron, and initiate heme synthesis, although cell death occurs much later. Cells destined to die express high levels of heme-responsive genes, including ribosomal protein and globin genes, whereas surviving cells downregulate heme synthesis and upregulate DNA damage response, hypoxia, and HIF1 pathways. Surprisingly, 24% ± 12% of cells from control subjects follow the unhealthy trajectory, implying that heme might serve as a rheostat directing cells to live or die. When heme synthesis was inhibited with succinylacetone, more DBA cells followed the healthy trajectory and survived. We also noted high numbers of messages with retained introns that increased as erythroid cells matured, confirmed the rapid cycling of colony forming unit–erythroid, and demonstrated that cell cycle timing is an invariant property of differentiation stage. Including unspliced RNA in pseudotime determinations allowed us to reliably align independent data sets and accurately query stage-specific transcriptomic changes. MDS-5q (unlike DBA) results from somatic mutation, so many normal (unmutated) erythroid cells persist. By independently tracking erythroid differentiation of cells with and without chromosome 5q deletions, we gained insight into why 5q+ cells cannot expand to prevent anemia.
Identification of ORM1, vWF, SPARC, and PPBP as immune-related proteins involved in immune thrombocytopenia by quantitative LC-MS/MS
Authors: Yin Dong-mei , Yuan Dai , Sun Rui-jie , Xu Hong-zhi , Hun Shou-yong , Sui Xiao-hui , Shan Ning-ning 
Published: June 2023

Abstract
Background
Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by loss of immune tolerance to platelet autoantigens leading to excessive destruction and insufficient production of platelets.

Method
Quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) was performed to detect the differentially expressed proteins in bone marrow samples from active ITP patients and normal controls.

Result
Our bioinformatic analysis identified two upregulated proteins (ORM1 and vWF) and two downregulated proteins (PPBP and SPARC) related to immune function. The four proteins were all found to be related to the tumor necrosis factor (TNF) -α signalling pathway and involved in the pathogenesis of ITP in KEGG pathway analysis.

Conclusion
Bioinformatics analysis identified differentially expressed proteins in bone marrow that are involved in the TNF-α signalling pathway and are related to the activation of immune function in ITP patients. These findings could provide new ideas for research on the loss of immune tolerance in ITP patients.
Brazilian teachers’ views and experiences regarding teaching biodiversity in an evolutionary and phylogenetic approach
Authors: Araujo Leonardo Augusto Luvison , Santana Carolina Maria Boccuzzi , Franzolin Fernanda 
Published: June 2023

AbstractBackgroundThe centrality of evolution to the biological sciences is recognized by many authors. Given the importance of evolution to biology, we intend to understand if, and how, science and biology teachers teach about biodiversity from an evolutionary perspective. In the first part of the research (Study 1), teachers from all geographic regions of Brazil (n = 147) answered a questionnaire containing both open-ended and Likert scale items in order to compare biodiversity-related contents to evolution. Considering the results obtained, a second study sought to analyze what challenges and possibilities Brazilian teachers who were enrolled in a continuing professional development course find in their classroom practices and the teaching materials they use when approaching cladograms while teaching about the diversity of organisms, as well as the experiences they had with cladograms during their education. These teachers responded to open-ended questionnaires concerning their experiences when learning and teaching about cladograms.ResultsFindings in Study 1 revealed that the concepts with the least emphasis among teachers were those related to macroevolution and phylogenetics. We found in Study 2 that teachers recognize cladograms as an important biological representation. In general, they approach it in biology and science classes, but often not relating it to topics concerning biodiversity. Teachers reported using multiple resources for teaching about cladograms, but textbooks were the most used teaching material. However, teachers reported that textbooks do not approach the theme sufficiently enough and mentioned it as a challenge. They also reported learning about phylogenetic content during teacher education but did not discuss aspects regarding teaching about cladograms.ConclusionsThese findings suggest that it is important that teacher education courses and new teaching materials consider the importance of cladograms and the specificities of phylogenetics within the teaching context.
Dyslipidemia and its associated factors among adult cardiac patients at Ambo university referral hospital, Oromia region, west Ethiopia
Authors: Addisu Bedasa , Bekele Shiferaw , Wube Temesgen Bizuayehu , Hirigo Agete Tadewos , Cheneke Waqtola 
Published: June 2023

Abstract
Background
Cardiovascular disease is a cluster of illnesses that affect the heart and blood vessels. Dyslipidemia is the most common risk factor for cardiovascular disease, causing more than 4 million deaths each year worldwide. However, there is very little evidence concerning the prevalence and pattern of dyslipidemia among cardiac patients in Ethiopia.

Methods
Hospital-based cross-sectional study was conducted from June to September 2022 at Ambo University referral hospital. Data on socio-demographic, clinical and anthropometric features were collected from adults with cardiac diseases using a convenient sampling technique. Lipid profiles and uric acid were measured from overnight fasting blood. The national cholesterol education program adult treatment panel (NCEP-ATP) III criteria was used to define dyslipidemia.

Results
A total of 269 participants were enrolled and the overall 76.6% [95% confidence interval (CI):72.1–81] of patients had at least one dyslipidemia. The prevalence of total cholesterol (TC) ⩾200 mg/dl, triglyceride (TG), LDL-cholesterol and HDL-cholesterol < 40 mg/dl were 38.9%, 44.6%, 29.4%, and 53.5%, respectively. Age > 54 was associated with TC and TG dyslipidemia, adjusted odds ratio (aOR) and (95% CI) were 2.6(1.4–4.8) and 2.4(1.2–4.7), respectively. While, a family history of heart disease, sedentary lifestyle and obesity were associated with TC dyslipidemia, aOR (95%CI) were 1.9(1.1–3.5), 1.4 (1.4–14.6) and 6.7 (1.4–32.5), respectively. In addition, diabetetes mellitus and abdominal obesity were significantly associated with TG dyslipidemia, aOR (95%CI) were 1.9(1.0–3.6) and 2.6(1.16–5.8), respectively. Moreover, uric acid was positively correlated with TC and TG level.

Conclusions
The results indicate that more than 75% of the cardiac patients had at least one dyslipidemia. This reflects the need for regular monitoring of lipid profiles and intensive counseling in this population to mitigate further cardio-metabolic complications.
Local anesthetics systemic toxicity in children: analysis of the French pharmacovigilance database
Authors: Schweitzer-Chaput Arnaud , Callot Delphine , Bouazza Naim , Lesage Fabrice , Oualha Mehdi , Paret Nathalie , Boyer-Gervoise Marie , Treluyer Jean-Marc , Chouchana Laurent 
Published: June 2023

Abstract
Purpose
To characterize clinical profile of pediatric local anesthetic (LA) systemic toxicity (LAST) and to identify determinants of life-threatening outcomes.

Methods
Spontaneous reports notified to the French Pharmacovigilance Network were retrieved and followed by a case-by-case review, according to the following criteria: LA as suspected drug, age < 18 years, adverse drug reactions related to nervous system, cardiac, respiratory, psychiatric or general disorders. Multivariate logistic regression analysis was performed to identify factors leading to life-threatening reaction (i.e. continuous seizures or cardiorespiratory arrest).

Results
Among 512 cases retrieved, 64 LAST cases were included (neonates 11%, infants 30%, children 36%, adolescents 23%) mainly involving lidocaine (47%), lidocaine + prilocaine (22%) and ropivacaine (14%). Toxicity profiles were neurological (58%), cardiac (11%) or mixed (20%) and 7 patients (11%) developed methemoglobinemia. LAST was life-threatening for 23 patients (36%) and 2 patients died. Doses were above recommendations in 26 patients (41%) and were not different between life-threatening and non-life-threatening cases. The context of use (general and orthopedic surgery, p = 0.006) and the type of LA agent (lidocaine, p = 0.016) were independently associated with a life-threatening outcome.

Conclusion
In this national retrospective analysis, LAST in children appear to be a rare event. Neurological and cardiac signs were the most frequently reported reactions. LAST in children can be life-threatening, even at therapeutic doses. Although a fatal outcome may anecdotally occur, the vast majority of patients recovered after appropriate medical care.
YouTube as a source of information on preventing the use of valproic acid in women during pregnancy
Authors: Qu Boyang , Kang Binbin , Chen Xingyang , Ao Yanrong , Wang Liping , Cui Weiwei 
Published: June 2023

Abstract
Background
YouTube™ (http://www.youtube.com), as a very popular video site worldwide, is increasingly being used as a platform to disseminate health information. The purposes of this review were to assess the overall usefulness of the information on the prevention of valproic acid use in women during pregnancy on YouTube™ for patients.

Methods
The YouTube™ website was systematically using 8 keywords. One hundred and fifty four videos meet the selection criteria. The researcher evaluated the video duration, days since upload, views and the likes. These videos are categorized as Education, News & Politics and People & Blogs. We designed a usefulness scoring scheme to assess videos quality and classified them as “slightly useful”, “useful” and “very useful”. The Kruskal-Wallis test was used to determine whether differences existed between total usefulness scores and categories and Pearson chi-square test for categorical variables.

Results
The majority of videos were educational (62.8%). The "People & Blogs" and "News & Politics" videos scored significantly higher, but had no significant difference in days since upload, views, views/day or likes. More than half of the videos (91/154) were categorized as “useful”. The mean posted days (p = 0.045) was significantly different in the useful group compared with the slightly useful group. There were no correlation between usefulness and the number of days since upload, duration, views, views/day, or likes.

Conclusion
YouTube™ is a promising source of information regarding the use of valproic acid during pregnancy. "News & Politics" videos are the most usefulness. Considering the presence of more slightly useful information, publishers need to improve more comprehensive video content that includes replacement medications, diagnoses and treatments. In the healthcare information space, consumers need to be directed to reliable video.
Early retirement intentions among Abu Dhabi Police: investigating the role of psychosocial work factors and sickness absenteeism
Authors: Alkaabi Faisal Almurbahani , Maghelal Praveen Kumar 
Published: June 2023

Abstract
Background
Police departments are encouraged to integrate their health and safety management systems with the operational arrangements to demonstrate commitment to the improvement of working environment in the police is by the collection and analysis of occupational health data such as sickness absence and early retirement intention.

Methods
About 760 responses to the Occupational Health and Safety Survey by the Abu Dhabi Police employees was used to analyse the early retirement intentions considering the work-related factors and sickness absence data.

Results
Logistic regression results of the unadjusted model reported higher odds that lower levels of co-worker support, supervisor support, workplace support related to intentions of early retirement. Also, unfavourable perception of health management increases the odds to early retirement among the employees.

Conclusion
The outcome of this study provides insights into the determinants of early retirement intentions in the less explored region of middle-east, specifically in Abu Dhabi. Thorough analysis of such data will help police organisations to prioritise plans and improve the health and wellbeing of officers, in turn contributing to strengthening the fight against crime and minimizing the number of occupational injuries and premature exit from paid work.