bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blockchain‐enhanced trust management for mobile edge computing‐enabled intelligent vehicular collaboration in the 6G era
Authors: Wang Xifeng , Zhu Hongsong , Xiao Han , Zhou Zan , Yang Shujie , Sun Limin 
Published: May 2023

AbstractThe rapid development and increasing popularity of mobile devices have facilitated the development of computation‐intensive applications and services, but their constrained compute, storage and battery capabilities have also created the requirements for optimized resource provision and service orchestration. Emerging mobile edge computing (MEC) and next‐generation networks (6G) can meet these requirements of mobile devices by migrating complex computing tasks and large volumes of data to edge servers with acceptable latency, thus effectively enhancing the quality of experience (QoE) of mobile users. Intelligent Vehicular Collaboration, as an intelligent mobile application or service in intelligent connected vehicle (ICV) applications, enables precise and effective driving decisions based on a large amount of real‐time traffic information statistics and intelligent analysis of vehicle status to improve the user driving experience and the efficiency of intelligent transportation systems(ITS). However, the openness and dynamics of wireless communications and the high frequency of information interaction of MEC‐enabled intelligent vehicular collaboration services in the 6G era make them highly vulnerable to cyber attacks. How to achieve dynamically trustworthy, secure, and intelligent vehicular collaboration services in the presence of malicious node access and cyber attacks in the 6G MEC‐enabled vehicular network is a significant challenge. In this paper, we propose a novel blockchain‐enabled trust management mechanism to address this challenge. First, we design a spatiotemporal‐correlated message credibility assessment method and a dynamic mutual trust evaluation method to obtain accurate ratings for messages and mobile nodes respectively. Based on the above methods, we propose an improved blockchain‐based intelligent trust management mechanism that enables transparent, tamper‐evident, and trustworthy secure intelligent vehicular collaboration services while maintaining stable and efficient system performance. Simulation results show that our suggested solutions can efficiently evaluate the trust level of ICVs and achieve efficient and secure intelligent vehicular collaboration with acceptable communication and computation overheads.
Heat transport in magnetohydrodynamic physiological blood flow through a constricted artery
Authors: Mukhopadhyay Subrata , Mandal Mani Shankar 
Published: May 2023

AbstractIn this paper, we study how the magnetohydrodynamic (MHD) pulsatile flow of blood and heat transfer works through a constricted artery with a flexible wall. The human circulatory network consists of veins and arteries that sometimes contain constrictions, allowing the impact of the applied magnetic field on flow fields to be observed. The walls of the flowing medium are considered to be a function of time. The flowing blood is hypothesized as shear‐thinning fluid, emulating Yeleswarapu's viscosity replica. Additionally, we consider the energy equation to understand the impact of a magnetic field on heat transfer rates for such flows. The vorticity transport equation along with the stream function equation is obtained using the vorticity–stream function technique. Numerical solutions of the governing nonlinear MHD equations and energy equation in addition to physically pertinent flow conditions were achieved by adapting a finite difference scheme. Considerable attention has been paid to ensure an accurate comparison between the current and previous results. The two sets of numbers appear to match closely. For an even deeper understanding of the flow and heat transport process, the effects of height of stenosis and diverse physiological parameters on time‐averaged wall shear stress (TAWSS), rate of heat transport, and so on are explored in depth through their graphical depiction. In the vicinity of the constriction, it is observed that the separation becomes longer with increasing constriction height. Higher magnetic force strength leads to a reduction in separation length. Newtonian fluids transfer heat more rapidly in their narrowing regions and downstream than fluids with non‐Newtonian behavior.
Phospholipase D2 targeted by miR‐5132‐5p alleviates cerulein‐induced acute pancreatitis via the Nrf2/NFκB pathway
Authors: Wu Hailong , Chen Hao , Zhou Rui 
Published: May 2023

AbstractBackgroundAcute pancreatitis (AP) is an inflammatory process unexpectedly occurring in the pancreas, imposing a substantial burden on healthcare systems. Herein, we aimed to clarify the mechanism of action of phospholipase D2 (PLD2) in cerulein‐treated AR42J cells, affording valuable insights into the treatment of AP.MethodsThe levels of PLD2, miR‐5132‐5p, inflammatory factors (interleukin [IL]−10, IL‐6, and tumor necrosis factor‐α), caspase‐3 activity, and apoptosis‐related proteins (Bax and Bcl‐2) in cerulein‐treated AR42J cells were detected using reverse transcription‐quantitative polymerase chain, caspase‐3 activity, and Western blot analysis. Protein levels of nuclear Factor erythroid 2‐Related Factor 2 (Nrf2) and nuclear factor‐k‐gene binding (NF‐κB) were detected by Western blot analysis. TargetScan predicted upstream microRNAs (miRNAs) of PLD2, and the interaction between miR‐5132‐5p and PLD2 was verified using a luciferase assay.ResultsIn cerulein‐treated AR42J cells, PLD2 levels were downregulated, while miR‐5132‐5p expression was upregulated. Overexpression of PLD2 attenuated the cerulein‐mediated facilitatory effect on inflammation and apoptosis in AR42J cells by regulating the Nrf2/NFκB pathway. Luciferase reporter analysis revealed that miR‐5132‐5p targeted PLD2, and miR‐5132‐5p negatively regulated PLD2. Upregulation of miR‐5132‐5p expression exacerbated inflammation and apoptosis and reversed the protective effect of PLD2 overexpression on AP.ConclusionPLD2 targeted by miR‐5132‐5p can attenuate cerulein‐induced AP in AR42J cells via the Nrf2/NFκB pathway, providing therapeutic targets for patients with AP.
Pilot‐scale photocatalytic detoxification and disinfection of hazardous medical wastewater
Authors: Berberidou Chrysanthi , Tsoumachidou Sophia , Paspaltsis Ioannis , Kitsiou Vasiliki , Kanata Eirini , Xanthopoulos Konstantinos , Sklaviadis Theodoros , Arsenakis Athansios , Poulios Ioannis 
Published: May 2023

AbstractBACKGROUNDTreatment of liquid hazardous medical wastewater produced by healthcare laboratories is a global matter that has been inadequately addressed. In this study, the potential of heterogeneous and homogeneous photocatalytic oxidation to detoxify and disinfect such effluents was investigated. Experiments were performed using two toxic effluents and one of simultaneous toxic and infectious composition in pilot scale, in a novel photocatalytic inactivation system.RESULTSPhotocatalytic experimental runs performed with both toxic effluents showed that photo‐Fenton‐assisted TiO2 photocatalytic oxidation under optimal conditions was the most efficient process among the tested ones, when the initial dissolved organic carbon values (DOC0) ranged from 100 to 1000 mg L−1. Furthermore, the potential of catalyst reuse was examined and verified for five sequential runs. Moreover, phytotoxicity was either eliminated or significantly reduced after photocatalytic processing under optimal conditions in the case of the second wastewater of toxic composition, while ecotoxicity showed a similar trend, highlighting the importance of extended mineralization for the removal of toxicity. The performance of the pilot photocatalytic inactivation system concerning the inactivation of bio‐pollutants was tested on five different types of microbes. Four of them were completely inactivated in relatively short periods, while survival of the more resistant bacterial endospores was found to be decreased to >99% after 5 h of treatment.CONCLUSIONToxic and infectious hazardous medical effluents are highly recalcitrant targets in terms of mineralization, detoxification and inactivation. However, photocatalytic oxidation may serve as an efficient processing tool, providing alternative or complementary solutions to this highly challenging issue. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Reliability and validity of behavioral‐economic measures: A review and synthesis of discounting and demand
Authors: Miller Brandon P. , Reed Derek D. , Amlung Michael 
Published: May 2023

AbstractThis review sought to synthesize the literature on the reliability and validity of behavioral‐economic measures of demand and discounting in human research, introduce behavioral‐economic research methodologies for studying addictive behaviors, discuss gaps in the current literature, and review areas for future research. A total of 34 studies was included in this review. The discounting literature showed similar responding regardless of whether hypothetical or actual outcomes were used, though people tended to discount the outcome presented first more steeply, suggesting order effects. Although delay‐discounting measures seem to show temporal stability, exceptions were found for probability‐ and experiential‐discounting tasks. The demand literature also demonstrated similar responding regardless of outcome type; however, some demand indices showed exceptions. Randomized price sequences tended to show modest increases in Omax and α and modestly higher rates of inconsistent or nonsystematic responses compared with sequential price sequences. Demand indices generally showed temporal stability, although the stability was weaker the larger the time interval between test sessions. Future studies would benefit by examining addictive commodities beyond alcohol, nicotine, and money; examining temporal stability over longer time intervals; using larger delays in discounting tasks; and using larger sample sizes.
Odd edge‐colorings of subdivisions of odd graphs
Authors: Petruševski Mirko , Škrekovski Riste 
Published: May 2023

AbstractAn odd graph is a finite graph all of whose vertices have odd degrees. A graph is decomposable into odd subgraphs if its edge set can be partitioned into subsets each of which induces an odd subgraph of . The minimum value of for which such a decomposition of exists is the odd chromatic index, , introduced by Pyber. For every , the graph is said to be odd ‐edge‐colorable. Apart from two particular exceptions, which are, respectively, odd 5‐ and odd 6‐edge‐colorable, the rest of connected loopless graphs are odd 4‐edge‐colorable, and moreover one of the color classes can be reduced to size . In addition, it has been conjectured that an odd 4‐edge‐coloring with a color class of size at most 1 is always achievable. Atanasov et al. characterized the class of loopless subcubic graphs in terms of the value . In this paper, we extend their result to a characterization of all loopless subdivisions of odd graphs in terms of the value of the odd chromatic index. This larger class is of a particular interest as it collects all “least instances” of nonodd graphs. As a prelude to our main result, we show that every connected graph requiring the maximum number of four colors, becomes odd 3‐edge‐colorable after removing a certain edge. Thus, we provide support for the mentioned conjecture by proving it for all subdivisions of odd graphs. The paper concludes with few problems for possible further work.
Three‐component synthesis of arene‐linked pyrazolo[1,5‐a]pyrimidines
Authors: Ahmed Ahmed A. M. , Mekky Ahmed E. M. , Sanad Sherif M. H. 
Published: May 2023

AbstractIn this study, we aimed to establish an efficient method for synthesizing two new series of arene‐linked pyrazolo[1,5‐a]pyrimidines. This was achieved by reacting 1H‐pyrazole‐3,5‐diamines with the respective acetophenones and benzaldehydes in a 1:1:1 ratio. To optimize this three‐component reaction, various bases, and solvents were investigated. Use of two equivalents of KOH in ethanol at reflux for 4–6 h resulted in 89%–96% yields of the desired products. Structure of new products was elucidated by considering their elemental and spectral data.
Interference of cardiac implantable electronic devices and computed tomography imaging in the current era with a phantom model
Authors: Ideishi Akihito , Yamagata Kenichiro , Nishii Tatsuya , Miyanooi Hideto , Miyazaki Yuichiro , Wakamiya Akinori , Shimamoto Keiko , Ueda Nobuhiko , Nakajima Kenzaburo , Wada Mitsuru , Kamakura Tsukasa , Ishibashi Kohei , Inoue Yuko , Miyamoto Koji , Noda Takashi , Nagase Satoshi , Aiba Takeshi , Kusano Kengo 
Published: May 2023

AbstractIntroductionCardiac implantable electronic devices are used in patients with cardiac rhythm disorders. Computed tomography irradiation is not prohibited for patients with cardiac implantable electronic devices, despite adverse events being reported. Hence, appropriate preparation and knowledge are required before computed tomography irradiation can be carried out in these patients. Since there is limited knowledge or literature about the influence of computed tomography irradiation in cases with recent cardiac implantable electronic devices, we aimed to evaluate the adverse events and elucidate the necessary and sufficient safety measures associated with this therapy.Methods and ResultsWe placed cardiac implantable electronic devices on an anthropomorphic phantom model and observed their electrical activity in electrograms, while various protocols of computed tomography irradiation were implemented and adverse events evaluated. Oversensing with pauses of up to 3.2 s was observed in standard computed tomography protocols, but ventricular tachyarrhythmia or other clinically significant events could not be confirmed. Oversensing with pauses of up to 8.0 s was observed and ventricular tachyarrhythmia was detected in the maximum‐dose protocols. However, treatments such as antitachycardia pacing or shock therapy for ventricular tachyarrhythmia were not observed because of their absence.ConclusionComputed tomography irradiation for patients using cardiac implantable electronic devices is highly unlikely to cause clinically significant adverse events with the device settings and computed tomography protocols currently being used. Changing or monitoring the device settings routinely before computed tomography irradiation is not necessarily required for most patients.
On the varied impact of the Storegga tsunami in northwest Scotland
Authors: Woodroffe Sarah A. , Hill Jon , Bustamante‐Fernandez Emmanuel , Lloyd Jerry M. , Luff Jake , Richards Sarah , Shennan Ian 
Published: May 2023

ABSTRACTIn this paper we evaluate new data and those from previous studies in northwest Scotland and perform a modelling study to test the hypothesis that the Storegga tsunami (submarine slope failure off the continental shelf of Central Norway dated to 8120–8175 bp) impacted this region. The model used is a 2D non‐linear, non‐conservative, Shallow Water Equation solver incorporating inundation and realistic glacial isostatic adjustment‐corrected palaeobathymetry, with horizontal resolution down to 30 m at sites of interest. The 15 coastal study sites analysed range from south of the Isle of Skye to Assynt. We predict run‐up between 2.7 and 9.4 m above contemporaneous mean tide level across the region, with the highest on the west coast of the Outer Hebrides, the east coast of Skye and at the head of long sea lochs east of Skye. We re‐evaluate evidence from previously studied open coastal marshes, isolation basins and barrier locations for the tsunami and suggest that in many locations the Storegga tsunami is the most likely cause of erosion, deposition and changes in microfossil assemblages in the early Holocene. The predictions of wave height and inundation produced by the tsunami modelling fit well with the range of available field evidence in the region. We predict significant wave heights at least as far south as Mull on the west coast.
WALKING THE LEADERSHIP TIGHTROPE
Authors: Cherches Todd 
Published: May 2023

AbstractThe author, the CEO of a management consulting firm, explains his concept of “Visual Leadership” also expressed as “VisuaLeadership.” He describes it as “one of the most effective ways to think, to communicate, to connect, to coach, and to lead is via the use of visual imagery and visual language. This could include anything from pictures and props to mental models, metaphors, and stories.” He employs as example and metaphor the tightrope walking of Nik Wallenda’s famous 2013 Grand Canyon wire‐walk. He outlines in more detail ten concepts, which in his words are 1. You’re not alone up there; 2. Know who to listen to—and when; 3. There are people rooting for you… to fall; 4. Don’t look down, and don’t look back; 5. Stop and catch your breath occasionally; 6. Keep your eyes on the prize; 7. Confidence is key; 8. Don’t start with the Grand Canyon; 9. Practice, Practice, Practice; 10. Don’t Forget to Reflect, Celebrate, and Share the Success. For instance, with the latter: “Too often, we move on to the next challenge before making the time and taking the time to reflect on and to celebrate our accomplishments…along with recognizing the contributions of the people who helped us along the way.”
THE SLOW LANE: MOVEMENTS FOR SOCIAL PROGRESS
Authors: Haselmayer Sascha 
Published: May 2023

AbstractThe author, a seasoned social entrepreneur who is based in Berlin and works for Ashoka Innovators for the Public, writes about his concept of the Slow Lane, and how it contrasts with quick fixes, which he feels mostly do not work and can be destructive. He points to slow lane effectiveness in the wake of the 2007–2008 global financial crisis, and the subsequent strength of decisions taken by the Spanish government. He also describes the slow lane economic triumphs of Iceland. “Slowing down to listen,” he writes, “helped Iceland not only lower the pain for citizens, but it also delivered a much faster recovery. I like to think of this as the dividend of slowness.” There are also smaller examples, such as the nonprofit User Voice at “Pentonville Prison, a notorious prison in London.” The organization “brings ex‐offenders into prisons, to find out what prisoners really need.” The author delineates five slow lane principles, which in his words are 1. Hold the urgency; 2. Listen; 3. Share the agency; 4. Nurture curiosity; 5. Use technology as an enabler. He concludes that the slow lane is “a space of creativity, activism, and entrepreneurship that serves as our repository of social imagination.”
NO GOING BACK: IT iS TIME TO ACCELERATE ORGANIZATION CULTURE CHANGE
Authors: Miller Frederick A. , Katz Judith H. 
Published: May 2023

AbstractThe authors, who have significant experience in Organization Development/OD, write about the unprecedented need for organizations to “change faster!” This situation has been brought on by the pandemic, which “accelerated many of the changes that have been underway or talked about for years.” This has major implications for how organizations treat their employees, and how those employees can carry out their work most effectively. “The work contract between the individual and their employer,” according to the authors, “was under pressure to be more favorable to employees, once again the pandemic said, go faster.” They note that this is happening not just in the corporate sectors, but everywhere. They caution that “the need today is to give these current opportunities and challenges your best thinking and act as fast as possible to respond to today’s situations.” They delineate “five key areas of change,” which in their words are: 1. Listening and Curiosity Become Core Competencies; 2. The “Employee” Centric Workplace is Happening; 3. Defining and Repurposing the Workplace for Today’s Reality; 4. Diversity of Thought and an Inclusive Culture Wins! 5. Creating the Glue for a Community of Effort. As the authors point out, “It is time to redefine, repurpose, and recreate the organization.”
THE IMPORTANCE OF A TAILORED HYBRID WORK MODEL DECISION FRAMEWORK FOR DIFFERENT DEPARTMENTS AND ROLES
Authors: Tsipursky Gleb 
Published: May 2023

AbstractThe author, CEO of the boutique future‐of‐work consultancy Disaster Avoidance Experts, explains how executives can help making decisions in today’s fluid and often‐confusing world of hybrid work. He points to examples of organizations he has worked with, and research carried out by others on the topic. He outlines the need for a “customized approach, dependent on the job function and nature of collaboration between team members within each one.” These changes have been accelerated due to the pandemic, but now executives must plan for new realities in which these changes, once thought to be temporary, are fast‐becoming the norm. “The basis for the decision framework,” he writes, “centers around two distinct questions. First, what kind of work is best done remotely, and what in the office? Second, what type of work is done in each department and by different roles within them?” These ideas prompt thoughts such as what becomes the role of areas such as spontaneity, and chance in‐encounters that can fuel productivity and creativity. He writes that “one of the key challenges of maintaining company culture for remote or hybrid workers is the decrease in cross‐functional weak connections across staff. This loss of connections can negatively impact long‐term company success, since achieving organizational goals often requires cross‐functional collaboration.”
PROTACs: A novel strategy for cancer drug discovery and development
Authors: Han Xin , Sun Yi 
Published: May 2023

AbstractProteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists of three components: a small molecule that binds to a target protein, an E3 ligase ligand (consisting of an E3 ligase and its small molecule recruiter), and a chemical linker that hooks first two components together. In the past 20 years, we have witnessed advancement of multiple PROTAC degraders into the clinical trials for anticancer therapies. However, one of the major challenges of PROTAC technology is that only very limited number of E3 ligase recruiters are currently available as E3 ligand for targeted protein degradation (TPD), although human genome encodes more than 600 E3 ligases. Thus, there is an urgent need to identify additional effective E3 ligase recruiters for TPD applications. In this review, we summarized the existing RING‐type E3 ubiquitin ligase and their small molecule recruiters that act as effective E3 ligands of PROTAC degraders and their application in anticancer drug discovery. We believe that this review could serve as a reference in future development of efficient E3 ligands of PROTAC technology for cancer drug discovery and development.