bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-BPC04-5: DIFFERENCE BETWEEN MORNING AND EVENING BLOOD PRESSURE AT HOME AND NOCTURNAL HYPOXIA IN THE GENERAL PRACTITIONER-BASED J-HOP STUDY
Authors: Hoshide Satoshi , Kario Kazuomi 
Published: January 2023

Objective:
The increase of morning home blood pressure (BP) compared to evening home BP defined as morning minus evening home BP (MEdif) was also associated with target organ damage and cardiovascular prognosis. A majority of previous studies have shown the determinant of MEdif from the point of demographic characteristics, but not from pathophysiological feature.

Methods:
The analysis of this study included participants from the baseline who performed home BP measurements and a portable pulse oximeter during nighttime in the Japan Morning-Home Blood Pressure (J-HOP) study, which is a practitioner-based, prospective, observational cohort study of a large Japanese outpatient population who had home BP measurement with the same validated device.

Results:
In the study of 1053 participants with at least cardiovascular risk, the prevalence of the individuals with 20 mmHg in MEdif was 14.0%. In univariate linear regression analysis, minimum SpO2 (beta = -0.19, P < 0.001) and oxygen desaturation index (beta = 0.06, P = 0.049) was associated with MEdif, but not in mean SpO2 (beta = -0.10, P = 0.496). After adjustment for covariates, only the association between minimum SpO2 and MEave was remained (beta = -0.15, P = 0.002). Dividing the participants into quartiles according to the minimum SpO2, the lowest (Odds ratio [OR], 1.98; 95% confidence interval [CI], 1.13–3.49) and third quartile (OR, 1.76; 95%CI, 1.02–3.04) were significantly determinant of those with ≧ 20 mmHg in MEdif than the top quartile.

Conclusion:
Increased MEdif in the Japanese population with at least one cardiovascular risk. When physicians find increased MEdif, especially greater than or equal to 20 mmHg, the possible impact of nocturnal hypoxia could be accounted.
PS-BPC05-1: HEART RATE VARIABILITY INDICES AS POTENTIAL POST-TRAUMATIC STRESS DISORDER BIOMARKERS
Authors: Cardoso Claudia F , Ohe Natalia T , Bader Yazan , Afify Nariman , Homedi Zahrah Al , Alwedami Salma M , OSullivan Siobhan , Campos Luciana A , Baltatu Ovidiu C 
Published: January 2023

Objective:
Psychological distress, such as posttraumatic stress disorder (PTSD), is commonly evaluated using subjective questionnaires, a method prone to self-report bias. The working hypothesis was that levels of autonomic dysfunction determined by heart rate variability (HRV) measures are associated with the severity of PTSD in women following pregnancy loss.

Design and Methods:
This was an observational prospective cohort study with 53 patients enrolled. The DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) PTSD scale (PCL-5) was used to assess the severity of PTSD in women after pregnancy loss. The cardiac autonomic function was assessed using HRV measurements during a deep breathing test using an HRV scanner system with wireless ECG enabling real-time data analysis and visualization. HRV measures were: standard deviation (SD) of normal R-R wave intervals [SDNN, ms], square root of the mean of the sum of the squares of differences between adjacent normal R wave intervals [RMSSD, ms], and the number of all R-R intervals in which the change in consecutive normal sinus intervals exceeds 50 milliseconds divided by the total number of R-R intervals measured [pNN50 = (NN50/n-1)x100%] [pNN50%].

Results:
The PCL-5 scores had a statistically significant association with HRV indices (SDNN; RMSSD, and pNN50%). Patients with PTSD had similar mean heart rate values as compared to patients without PTSD (PCL-5), but significantly higher SDNN [median[IQR, interquartile range]: 90.1 (69.1 - 112.1) vs. 52.5 (36.8 - 65.6)], RMSSD [59.4 (37.5 - 74.9) vs. 31.9 (19.3 - 44.0)], and PNN50% values [25.7 (16.4 - 37.7) vs. 10.6 (1.5 - 21.9)]. The SDNN of the deep breathing test HRV was effective at distinguishing between patients with PTSD and those without, with an AUC = 0.83 +/- 0.06 (95 % CI 0.94, p = 0.0001) of the ROC model.

Conclusions:
In this study, HRV indices as biomarkers of cardiac dysautonomia were found to be significantly related to the severity of PTSD symptoms in women after pregnancy loss.
PS-BPC05-3: THE RELATIONSHIP BETWEEN THE WEIGHT-ADJUSTED-WAIST INDEX AND LEFT VENTRICULAR HYPERTROPHY IN CHINESE HYPERTENSION ADULTS
Authors: Cai Shuang 
Published: January 2023

Abstract

Background:
Left ventricular hypertrophy (LVH) is a major cardiac complication of hypertension. weight-adjusted-waist index (WWI) is a new obesity index that has been found to be positively associated with cardiovascular disease mortality. We aimed to investigate the relationship between the weight-adjusted-waist index and left ventricular hypertrophy in Chinese hypertension adults.

Methods:
The study is a community-based cross-sectional study that included 4715 patients with hypertension and integrated clinical and echocardiographic data. LVH was diagnosed by transthoracic echocardiography in these patients based on a criterion of left ventricular mass index (LVMI) over 49.2 g/m2.7 in men and 46.7 g/m2.7 in women. The independent association between the WWI quartiles and LVH prevalence was analyzed by logistic regression models.

Results:
The prevalence of LVH in the first quartile of WWI (Q1:less than 10.16), second (Q2:10.16∼10.67), the third (Q3:10.68∼11.19), and the highest quartile (Q4:greater or equal to11.20) was 34.1%, 38.4%, 42.4%, 51.5%, respectively. Logistic regression analysis suggested that the WWI was independently correlated with the risk of LVH with adjustment of confounding factors, and increased across the quartile of WWI. Compared to the first quartile of WWI (Q1), the odds ratios (ORs) and their 95% confidence intervals (CIs) for LVH in the increasing quartiles (Q2-Q4) were 1.33(1.08–1.63), 1.50 (1.19–1.89) and 2.28(1.74–2.99), respectively. In stratified analyses, the relationship between WWI and LVH risk persisted.

Conclusions:
The WWI may be an independent risk factor of LVH in Chinese hypertension adults.
PS-BPC05-6: PATIENTS WITH HEART FAILURE ACCOMPANIED BY A HYPERTENSIVE CRISIS HAD A RELATIVELY GOOD PROGNOSIS
Authors: Shin Mi Seung , Won Yoonsun , Yang Tae Il , Kim Joo Han , Lee Joonpyo , Seo Jungduk , Shin Young Hoon 
Published: January 2023

Objectives:
Blood pressure (BP) is a prognostic marker of heart failure with reduced ejection fraction (HFrEF). We find hypertensive crisis not uncommon in patients who complain of dyspnea. We aimed to determine the correlation between BP level and time to recovery in patients with HFrEF visiting the emergency department (ED).

Methods:
This observational study included patients aged /> 19 years who visited an ED between 2015 and 2018 for dyspnea. We analyzed the BP, clinical outcomes, and prognosis of 1136 patients with HFrEF, excluding patients with acute myocardial infarction or valvular heart disease, among 2690 patients. Patients were divided into four groups according to their initial BP level based on the ESC/ESH hypertension guideline. The hypertensive crisis was defined as systolic BP /> 180 mmHg and/or diastolic BP /> 110 mmHg, which was equivalent to grade 3 hypertension.

Results:
Among the 1136 patients, 638 (56.2%) were below high normal BP, 236 (20.8%) showed grade 1 hypertension, 169 (14.9%) showed grade 2 hypertension, and 93 (8.2%) showed grade 3 hypertension. The recovery rate of heart failure for 3 years by the group was 21.6%, 32.1%, 38.3%, and 62.7%. The time to recovery was 32.1, 28.3, 15.7, and 7.4 months for each group.

Conclusions:
The hypertensive crisis had a relatively good prognosis in patients with HFrEF when adequate BP control was achieved.
PS-BPC05-8: RELATIONSHIP BETWEEN EXECUTIVE DYSFUNCTION AND READMISSION IN PATIENTS WITH HEART FAILURE
Authors: Kaneko Tetsuya , Kotooka Norihiko , Node koich 
Published: January 2023

Objective:
The prevalence of cognitive impairment is high in patients with heart failure and is associated with poor prognosis. Executive dysfunction can influence self-care control and adherence in patients with heart failure. We examined the relationship between executive dysfunction and hospital readmission in patients with heart failure.

Design and Methods:
Patients with heart failure were observed prospectively using a telemonitoring system. Cognitive impairment was evaluated using the Mini-Mental State Examination (MMSE) and executive dysfunction using the Trail Making Test B (TMT-B) at baseline. Cognitive impairment was defined as an MMSE score ≧ 23 points, and executive dysfunction was defined as a TMT-B score ≧ 180 s. We assessed relevant associations using the readmission rate.

Results:
Overall, 37 participants were studied. At a median follow-up of 19.5 months, 15 participants (40.5%) were re-hospitalized for worsening heart failure. Readmission rates for worsening HF were significantly higher in the executive dysfunction group (TMT-B ≧ 180 s) compared to the non-executive dysfunction group (TMT-B < 180 s; log-rank test, p = 0.005). Of the participants with no cognitive impairment (MMSE > 23), 11 had executive dysfunction while 19 did not. Readmission rates for worsening heart failure were higher in participants with cognitive impairment who had executive dysfunction (hazard ratio, 3.72; 95% CI, 0.87–15.8; p = 0.076). Multivariate analysis revealed that executive dysfunction was an independent risk factor for readmission due to heart failure (hazard ratio, 6.26; 95% CI, 1.01–38.4; p = 0.049).

Conclusions:
Executive dysfunction, as assessed by TMT-B, is associated with an increase of readmission in patients with heart failure. TMT-B may be useful in assessing the risk of readmission in patients with heart failure, as this is difficult to identify with general cognitive assessments.
PS-BPC05-9: MYELOPEROXIDASE PROGNOSTIC ROLE IN HYPERTENSIVE PATIENTS AFTER MYOCARDIAL INFARCTION WITH ST-ELEVATION
Authors: Rodionova Iuliia , Kytya Inna , Kopytsya Mykilay 
Published: January 2023

Objectives:
The aim was to study the role of myeloperoxidase (MPO) in left ventricle hypertrophy prognosis in hypertensive patients with ST-elevation myocardial infarction (STEMI) within 12 months.

Design and Methods:
Patients were divided into two groups depending on the level of MPO (median 95.68 ng / ml). Group 1 (with MPO> 95.68 ng/ml) included 48 patients. Group 2 with MPO < 95.68 ng/ml included 48 patients. The level of MPO was determined in all patients on the first day of the disease by enzyme-linked immunosorbent assay using a set of reagents Human MPO Instant ELISA KIT, Invitrogen Austria. The endpoint included left ventricle hypertrophy onset/progression, and was assessed after 12 months of follow up.

Results:
In the analysis of the two groups, it was found that patients in group 2 had significantly higher MPO 159.17 IQR 97.81 to 189.23 compared with the first group 65.77 IQR 48.18 to 94.23 p = 0.039. In univariative logistic analyses MPO showed significant association with LV hypertrophy development, β; = 0.033;p < 0.001. Multivariate logistic analysis revealed the reverse correlation of MPO with the LV remodeling in 12 months follow up β; = 0.010; p = 0.0034.

Conclusion:
The increased level of MPO is a significant predictor for development of left ventricle hypertrophy in hypertensive patients after STEMI in 12 month follow up
PS-BPC06-1: RENIN-ANGIOTENSIN SYSTEM BLOCKER AND THE COVID-19 AGGRAVATION: REPORT BY THE COVID-19 REGISTRY JAPAN
Authors: Yoshihara Fumiki , Ohtsu Hiroshi , Nakai Michikazu , Tsuzuki Shinya , Hayakawa Kayoko , Terada Mari , Matsunaga Nobuaki , Yasuda Satoshi , Ogawa Hisao , Ohmagari Norio 
Published: January 2023

Objective:
The role of angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) in the pandemic context of coronavirus disease 2019 (COVID-19) continues to be debated. Patients with hypertension, diabetes mellitus, chronic renal failure, cerebro-cardiovascular disease, or chronic obstructive pulmonary disease (COPD), who often use ACEi/ARB, may affect risk of severe COVID-19. However, there are no data available on the association of ACEi/ARB use with COVID-19 severity in this population.

Design and method:
This study is an observational study of patients with a positive SARS-CoV-2 test and inpatient treatment at a healthcare facility, using the registry information of COVIREGI-JP. Our primary outcomes were consisting of in-hospital death, ventilator support, extracorporeal membrane oxygenation support, and ICU admission. Out of the 6,055 patients, 1,921 patients with preexisting hypertension, diabetes mellitus, chronic renal failure, cerebro-cardiovascular disease, or COPD were enrolled. We also evaluated 1,097 patients with hypertension.

Results:
Factors associated with an increased risk of the primary outcomes were aging, male sex, COPD, severe renal impairment, and diabetes mellitus. No correlations were observed with ACEi/ARB, cerebro-cardiovascular diseases, or hypertension. Associated factors in male patients were aging, renal impairment, hypertension, and diabetes. In female patients, factors associated with an increased risk were aging, ACEi/ARB, renal impairment, and diabetes, whereas hypertension was associated with a lower risk of the primary outcomes. In patients with hypertension, factors associated with an increased risk of the primary outcomes were aging, male sex, severe renal impairment, and diabetes mellitus, but not ACEi/ARB, cerebro-cardiovascular diseases, or COPD.

Conclusions:
Independent factors for the primary outcomes were aging, male sex, COPD, severe renal impairment, and diabetes, but not ACEi/ARB, in the COVID-19 patients with preexisting hypertension, diabetes mellitus, chronic renal failure, cerebro-cardiovascular disease or COPD. Based on this registry data analysis, more detailed data collection and analysis is needed with the cooperation of multiple healthcare facilities.
PS-BPC08-9: A COMPARISON OF THE EFFECTS OF ADRENALECTOMY AND TREATMENT WITH EPLERENONE ON VASCULAR FUNCTION IN PATIENTS WITH ALDOSTERONE-PRODUCING ADENOMA
Authors: Kishimoto Shinji , Oki Kenji , Maruhashi Tatsuya , Kajikawa Masato , Mizobuchi Aya , Harada Takahiro , Han Yiming , Hashimoto Yu , Yusoff Farina Mohamad , Nakashima Ayumu , Nakano Yukiko , Higashi Yukihito 
Published: January 2023

Background:
It is still unclear whether adrenalectomy has more beneficial effects than treatment with a mineralocorticoid receptor antagonist of eplerenone on vascular function in patients with aldosterone-producing adenoma (APA). The purpose of this study was to compare the effects of adrenalectomy and treatment with eplerenone on vascular function in patients with APA.

Methods:
Flow-mediated vasodilation (FMD) as an index of endothelium-dependent vasodilation and nitroglycerine-induced vasodilation (NID) as an index of endothelium-independent vasodilation were measured to assess vascular function before and after 3-month treatment with eplerenone and at 3 months after adrenalectomy in 23 patients with APA.

Results:
FMD and NID after adrenalectomy were significantly higher than those before treatment with eplerenone (5.4 ± 2.6% vs. 2.7 ± 1.9% and 14.8 ± 4.7% vs. 9.6 ± 4.6%, P < 0.01, respectively) and those after treatment with eplerenone (5.4 ± 2.6% vs. 3.1 ± 2.3% and 14.8 ± 4.7% vs. 11.0 ± 5.3%, P < 0.01 and P = 0.03, respectively), while treatment with eplerenone did not alter FMD and NID compared with those before treatment with eplerenone. After adrenalectomy, the increase in FMD and NID were significantly correlated with the decrease in PAC and the decrease in aldosterone-renin ratio. There were no significant relationships between FMD and changes in other parameters or between NID and changes in other parameters.

Conclusions:
Adrenalectomy, but not treatment with eplerenone, improved vascular function in patients with APA. Adrenalectomy may be more effective than treatment with eplerenone for reducing the incidence of future cardiovascular events in patients with APA.
PS-BPC09-1: SKELETAL MUSCLE MASS REDUCTION ASSOCIATED WITH INCREASED ARTERIAL VELOCITY PULSE INDEX AND TISSUE DAMAGE MARKER IN PATIENTS WITH CARDIOVASCULAR DISEASE
Authors: Harada Haruhito , Nishiyama Yasuhiro , Niiyama Hiroshi , Katoh Atsushi , Kai Hisashi 
Published: January 2023

Objectives:
Reduction of skeletal muscle mass is the most important component of sarcopenia. Aging and chronic diseases, including chronic heart failure, are the causes of reduced skeletal muscle mass. However, little is known about the mechanism of skeletal muscle mass reduction in patients with cardiovascular disease (CVD). The purpose of this study was to assess the association between skeletal muscle mass reduction and the indicators of early and advanced arterial damages in CVD patients.

Design and Methods:
This was a single-center, retrospective cross-sectional analysis including 310 inpatients with CVD. Bioelectrical impedance assay was used to measure skeletal muscle index (SMI) as well as bioelectrical phase angle (PA), a marker of tissue damage. Arterial velocity pulse index (AVI) was assessed for advanced vascular damages, such as arterial stiffening and increased peripheral resistance, using a commercially available instrument. Flow-mediated vasodilation (FMD) was performed to assess early vascular damages, i.e. endothelial dysfunction, using a commercially available, high-resolution, ultrasound device.

Results:
The mean age was 72 years (male, 57.7%). Symptomatic heart failure (AHA/ACC stage C and D) was observed in 19.4%. Sarcopenia was diagnosed in 25.5% of the whole group, according to the Asian Working Group for Sarcopenia criteria. Sarcopenic patients showed higher AVI and narrower PA than non-sarcopenic patients, suggesting as having severer arterial stiffness and tissue damage. Single regression analysis showed that SMI associated with AVI, FMD, PA, age, male sex, hypertension, diabetes mellitus, and dyslipidemia, but not with CKD and heart failure. Stepwise multivariate regression analysis revealed that age, male sex, AVI, PA, and hypertension were independent factors for SMI in CVD patients, whereas FMD, diabetes mellitus, and dyslipidemia were not.

Conclusion:
AVI was a significant marker for detecting sarcopenia in CVD patients independently of age and male sex. In addition, skeletal muscle mass reduction was correlated with a tissue damage marker, PA. Therefore, it is suggested that advanced vascular damages resulting arterio-/arteriolo-sclerosis, rather than early endothelial dysfunction, might be attributed to the reduction of skeletal muscle mass, possibly through damages of skeletal muscle tissue in CVD patients.
PS-BPC09-5: THE RELATIONSHIP BETWEEN CHANGES IN EXERCISE HABITS, PHYSICAL FUNCTION, AND PSYCHOLOGICAL STATUS IN OLDER PATIENTS WITH HYPERTENSION
Authors: Yasunobe Yukiko , Akasaka Hiroshi , Yamamoto Kouichi , Onishi Yuri , Minami Tomohiro , Yoshida Shino , Rakugi Hiromi 
Published: January 2023

Objective:
Self-restraint from activities due to the COVID-19 pandemic has limited the range of activities and interpersonal relationships for older persons. Moreover, prolonged restraint has been reported to increase the risk of frailty and sarcopenia. Therefore, we examined the effects of changes in exercise habits on physical function and psychological status of older patients with hypertension throughout their self-restraint lifestyle from 2020 to 2022 in the 1-year follow-up study.

Design and Methods:
Participants were patients with hypertension aged 65 years or older attending outpatient clinics at our institution who could obtain information on exercise habits, history of falls, comprehensive geriatric assessment, and muscle strength. We conducted the same survey in the first year and one year later. The subjects were classified into four groups by combining their exercise habits in the first year with or without one year later. That is Group A: with exercise habits at both times of the survey; Group B: with exercise habits in the first year and without exercise habits one year later; Group C: without exercise habits in the first year and with exercise habits one year later; and Group D: without exercise habits at both times of the survey. Written consent forms were obtained from all participants. Our institutional review board approved the study protocol.

Results:
The study participants were 183 patients (Group A: 119, Group B: 26, Group C: 17, Group D: 21). The age of the participants was 76.1 ± 5.5 years, 82 (44.8%) were male, and the duration of hypertension was 18.4 ± 11.5 years. Changes in exercise habits were not associated with physical function, history of falls, and comprehensive geriatric assessment at one year. However, when the results were examined separately for men and women, the geriatric depression scale was significantly higher in women in Group B (Dunnett test, p = 0.0094) than in Group A, suggesting that the tendency toward depression had progressed. Group B women also had more falls one year later (chi-square 12.04, p = 0.0072).

Conclusions:
In a 1-year follow-up study during the COVID-19 pandemic, a relatively high proportion of older patients with hypertension attending our hospital maintained their exercise habits, but 14% of cases lost their exercise habits. Only women showed the development of depression and increased risk of falls when exercise habits were lost. Women were more susceptible to the effects of environmental changes than men in older patients with hypertension.
PS-BPC10-6: RELATIONSHIP BETWEEN CIRCULATING ANGIOPOIETIN-LIKE PROTEIN 2 LEVELS AND ARTERIAL STIFFNESS IN PATIENTS RECEIVING MAINTENANCE HEMODIALYSIS
Authors: Morinaga Jun , Fukami Hirotaka , Okadome Yusuke , Matsunaga Eiji , Kuwabara Takashige , Oike Yuichi , Mukoyama Masashi 
Published: January 2023

Background and aims:
Chronic inflammation is receiving much attention as a critical pathology that induces various aging phenotypes, a concept known as “inflammaging’’. Uremic patients receiving hemodialysis show vascular aging phenotypes characterized by greater arterial stiffness and calcification compared to healthy controls. In this study, we investigated whether levels of inflammaging markers in the circulation were associated with vascular aging phenotypes in uremic patients, as estimated by the cardio-ankle vascular index (CAVI).

Methods:
We conducted a multicenter cross-sectional study of patients undergoing hemodialysis and evaluated the relationship between circulating high-sensitivity C-reactive protein (hs-CRP) or angiopoietin-like protein (ANGPTL) 2 levels, as markers of inflammaging, and CAVI.

Results:
Of 412 patients, 376 were statistically analyzed. While circulating hs-CRP levels had no significant association with CAVI, linear regression models revealed that high ANGPTL2 levels in circulation were significantly associated with increasing CAVI after adjustment for classical metabolic factors and hemodialysis-related parameters. Exploratory analysis revealed that high circulating ANGPTL2 levels were also strongly associated with increased CAVI, particularly in patients with elevated blood pressure, elevated pulse pressure, or excess body fluid.

Conclusions:
We conclude that circulating levels of ANGPTL2 rather than hs-CRP are positively associated with CAVI in the uremic patients and that ANGPTL2 could be a unique biomarker of progression of vascular aging in patients receiving hemodialysis.