bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic analysis: the protection of over-expression thioredoxin reductase 1 in Parkinson’s disease
Authors: Liu Zihua , Ye Qiang , Jiang Ying 
Published: April 2023

Abstract
Background
Parkinson’s disease (PD) is the second most common neurodegenerative disease. The pathologic characteristic feature is the loss of dopaminergic neurons in the substantia nigra (SN). However, the biochemical mechanisms are unclear.
A large number of studies have shown that oxidative damage is the primary cause of PD. Hence, antioxidants could become a suitable option to treat PD. The thioredoxin (Trx) system represents a useful, potentially disease-relevant oxidation–reduction system. Thioredoxin reductase 1 (TR1) is a significant component of the Trx system.

Methods
The overexpression lentivirus (LV) or LV-TR1 in the TR1-A53T model of PD by the stereotactic brain, and successful overexpression of LV or LV-TR1 in the MPP+-induced cellular model by LV or LV-TR1 transfection.

Results
We confirmed that interleukin-7 mRNA levels increased in MPP+ compared to that in the control and MPP+-TR1 groups using quantitative polymerase chain reaction. The γ-H2AX level was increased in the Tg-A53T group compared to that in the TR1-A53T group by western blotting. The expression of Na+-K+-ATP was decreased in the MPP+ group compared to that in the control and MPP+-TR1 groups by high content screening. Tg-A53T(the C57BL/6 mice transferred with mutant human a-syn); TR1-A53T(A53T mice which were injected TR1-LV 2 µl in SNc on two sides with minipump).The mice were fed for 10 months. control (the N2a cells cultivated with DMEM); MPP+(the N2a cells dealt with MPP+(1 mM) 48 h), MPP+-LV (the N2a cells over-expressed LV for 24 h then dealt with MPP+(1 mM) 48 h). MPP+-TR1(the N2a cell over-expressed TR1-LV for 24 h then dealt with MPP+(1 mM) 48 h).
From the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, we confirmed that the overexpression of TR1 in SN pars compacta cells decreased oxidative stress, apoptosis, DNA damage, and inflammatory response and increased NADPH, Na+-K+-ATP, and immune response in this PD model.

Conclusions
Our study shows that overexpressed TR1 can be developed as a neuroprotective agent for PD. Therefore, our findings demonstrate a new targeted protein for the treatment of PD.
Urban freight policy maturity and sustainable logistics: are they related?
Authors: Cowie Jonathan , Fisken Keith 
Published: April 2023

AbstractProblems associated with urban freight are well known and documented in the academic literature, particularly with regards to the impact on air quality and general intrusion of public space. As a defining principle however, urban freight has generally been left solely to operate on free market principles, with policy interventions generally being solely ‘problem’ focused. Given the underlying economics of freight transport, and particularly the cost advantages of road-based transport, intervention by public bodies is clearly a critical issue, however to date has received limited attention in the urban freight research literature. The aim of the current research is to examine if there is any relationship between the extent of local authorities’ freight policy development and the success of a policy driven (green) urban freight pilot initiative. This is based on five city case studies located across Northern Europe and uses an adapted form of Kiba-Janiak (Res Transp Bus Manag 24:4–16, 2017, https://doi.org/10.1016/j.rtbm.2017.05.003) five stages of ‘city maturity’ with regards to urban freight policy development. Each city’s policy framework is mapped onto one of these states of maturity. The success of the pilots in each city is then matched against the maturity of the policy framework. Taken at face value, the results show little correlation between the two, and hence the success of any initiative would appear to be independent of the policy framework. The real issue however is found to be low urban freight transport policy maturities within the case study sample, specifically a lack of tactical and operational functions, i.e. the ability to actually do something. The concern at the more general level is that what this leads to is policy stagnation.
Kimchi throughout millennia: a narrative review on the early and modern history of kimchi
Authors: Surya Reggie , Nugroho David 
Published: April 2023

AbstractKimchi, the traditional fermented vegetable dish from Korea, has been an integral part of the Korean food culture for thousands of years. Today, it is considered as a symbol of identity for Korean people and is globally appraised as a healthy food. The international standard of kimchi was stipulated by the Codex Alimentarius Commission in 2001, and kimjang, the traditional Korean communal activity of making kimchi, was listed as a UNESCO’s Intangible Cultural Heritage of Humanity in 2013. The international recognition that kimchi has today was not obtained easily since there have been international disputes with regard to its standard and originality. Many historical events have shaped the face of kimchi as it is today. Thus, it appears primordial to understand the hallmark historical events defining the development of kimchi from a traditional food consumed by only Koreans in the past to a renowned global healthy food today. This review explores the historical values of kimchi by focusing on both its early and modern history. The early history of kimchi gathered from different classical literature works suggests the existence of kimchi in Korea since thousands of years ago. The modern history of kimchi highlights different events, including the globalization and commercialization of kimchi, the “kimchi wars” against neighboring countries and the international branding of kimchi as a healthy food. Furthermore, this review also discusses the polemics of kimchi, particularly in terms of its originality. Understanding the historical values of kimchi would make people see kimchi not only as an ethnic food from Korea, but also as a valuable global heritage for the world that needs preserving.
Critical pedagogical designs for SETS knowledge co-production: online peer- and problem-based learning by and for early career green infrastructure experts
Authors: Feagan Mathieu , Fork Megan , Gray Geneva , Hamann Maike , Hawes Jason K. , Hiroyasu Elizabeth H. T. , Wilkerson Brooke 
Published: April 2023

AbstractDespite a growing understanding of the importance of knowledge co-production for just and sustainable urban transformations, early career green infrastructure experts typically lack opportunities to practice transdisciplinary knowledge co-production approaches within their normal training and professional development. However, using online collaboration technologies combined with peer- and problem-based learning can help address this gap by putting early career green infrastructure experts in charge of organizing their own knowledge co-production activities. Using the case study of an online symposia series focused on social-ecological-technological systems approaches to holistic green infrastructure implementation, we discuss how critical pedagogical designs help create favorable conditions for transdisciplinary knowledge co-production. Our work suggests that the early career position offers a unique standpoint from which to better understand the limitations of current institutional structures of expertise, with a view towards their transformation through collective action.
Double-edged sword of biofouling potentials associated with haemocompatibility behaviour: titania nanotube arrays for medical implant surface technology
Authors: Palaniyappan Keethaanjali , S. M. N. Mydin Rabiatul Basria , Widera Darius , Noordin Siti Salmah , Harun Nor Hazliana , Wan Eddis Effendy Wan Nuramiera , Hazan Roshasnorlyza , Sreekantan Srimala 
Published: April 2023

Abstract
Background
Medical implant failures are frequently associated with limitations of the surface technology that lead to biofouling and haemocompatibility issues. Titania nanotube array technology could provide a solution for this existing limitation. The present study describes the biofouling potential using the simulated body fluid model according to ISO 23317-2007 and haemocompatibility profiles according to ISO 10993-4 guidelines. Further haemocompatibility profiles were also assessed by evaluating full blood count, coagulation assays, haemolytic rate, whole blood clotting factor, platelet profiles, and FESEM characterization.

Result
Titania nanotube array nanosurface was found to present with better apatite biofouling and hydrophilic potential compared to bare titanium foil. Furthermore, good compatibility behaviour was observed based on the haemocompatibility profiles where no signs of thrombogenesis and haemolysis risks were observed. Titania nanotube array reduced fibrinogen adsorption, red blood cell and platelet adhesion and activation, which could be associated with detrimental biofouling properties.

Conclusion
Titania nanotube array could possess a double-edged sword of biofouling potentials that resist detrimental biofouling properties associated with thrombogenesis and haemolysis risk. It also provides better apatite biofouling potential for improved tissue and osseointegration activities. Knowledge from this study provides a better understanding of medical implant surface technology.

Graphical Abstract
Best Practices and Guidelines (2022) for Scale-up and Technology Transfer in Freeze Drying Based on Case Studies. Part 2: Past Practices, Current Best Practices, and Recommendations
Authors: Tchessalov Serguei , Shalaev Evgenyi , Bhatnagar Bakul , Nail Steven , Alexeenko Alina , Jameel Feroz , Srinivasan Jayasree , Dekner Michael , Sahni Ekneet , Schneid Stefan , Kazarin Petr , McGarvey Orla , Van Meervenne Bert , Kshirsagar Vaibhav , Pande Paritosh , Philipp Jens , Sacha Greg , Wu Ke , Azzarella Joseph , Shivkumar Gayathri , Bhatt Shreyas , Mehta Shyam B. 
Published: April 2023

Abstract
Scale-up and transfer of lyophilization processes remain very challenging tasks considering the technical challenges and the high cost of the process itself. The challenges in scale-up and transfer were discussed in the first part of this paper and include vial breakage during freezing at commercial scale, cake resistance differences between scales, impact of differences in refrigeration capacities, and geometry on the performance of dryers. The second part of this work discusses successful and unsuccessful practices in scale-up and transfer based on the experience of the authors. Regulatory aspects of scale-up and transfer of lyophilization processes were also outlined including a topic on the equivalency of dryers. Based on an analysis of challenges and a summary of best practices, recommendations on scale-up and transfer of lyophilization processes are given including projections on future directions in this area of the freeze drying field. Recommendations on the choice of residual vacuum in the vials were also provided for a wide range of vial capacities.
Graphical Abstract
Locked Up in Lockdown
Authors: Mahajan Nidhi 
Published: April 2023

AbstractThis essay traces how sailors aboard wooden sailing vessels (dhows) negotiate mobility across the Indian Ocean, revealing their precarious conditions preceding the COVID-19 pandemic that came to the fore after 2020. Focusing on Yusuf, a sailor in captivity in Iran during the pandemic, the essay suggests that the pandemic shone new light on preexisting patronage relations. However, these relations were creatively harnessed by laborers in times of crisis. Accustomed to sanctions regimes that restricted movement even before the pandemic, Yusuf facilitated his release through new patronage networks that built on his previous experiences of precarity. Rather than seeing this pandemic as a rupture, the essay argues that it led to an intensification of preexisting labor relations, such as patronage. The COVID-19 pandemic saw contagion, threat, vulnerability, devaluation, and precarity being used widely; however, these ideas were sutured to the Global South long before this pandemic, through sanctions regimes, occupation, and conflicts that restricted movement and disrupted supply chains. Patronage, then, was one mode in which maritime laborers navigated a geopolitical realm suffused with the language of threat and contagion. This essay charts a complex geopolitical reordering across the Global South, one not always mediated by the West.
BUILDING TALENT MANAGEMENT TECHNOLOGY IN AN ORGANIZATION
Authors: Kashtanova YEkatyerina , Lobacheva A. 
Published: April 2023

The article examines the process of talent management from the point of view of its use in order to motivate and retain employees with high potential. It is noted that talent development and high culture in the workplace are important in order to help employees realize their career potential in accordance with the vision of the organization. The authors consistently reveal the content of the stages of the talent management process in organizations, as well as provide recommendations for creating an organization attractive to employees with high potential.
THE WELL-BEING PROGRAM: RUSSIAN PRACTICES
Authors: Molodchik N. , Sosnina P. 
Published: April 2023

In the article, the employee welfare program — Well­being — is considered as a modern direction in the field of human resource management, on which productivity and employee loyalty largely depend. The historical aspects of the evolutionary development of this approach are revealed, the elements of the program that are necessary for systematic use are analyzed. The advantages, disadvantages and risks of implementing the Well­being system are revealed. A study was conducted and a list of recommendations for the implementation of the well­being program was compiled. Analytical business metrics are presented that allow assessing the level of employee well­being and managing the effectiveness of the program. Based on the results of a desk study in the context of each of the five elements of the program, examples of Well­being practices used in companies operating in Russia are given.
THE MEANING, ESSENCE AND CONTENT OF THE MOTIVATION SYSTEM IN MODERN CONDITIONS
Authors: Koroleva T. , Suvalova Tatyana 
Published: April 2023

The article considers the meaning, essence and content of the motivation system in modern conditions. Motivation of the entire work activity of all personnel of any organization should be considered as a system of complex impact of various internal and external factors on all employees to achieve certain goals of the organization. Having an obvious interest of each organization in higher motivation of employees is the process of encouraging all personnel to achieve various personal goals, as well as to meet their own needs through work. The success of a company is largely determined by decisions and the quality of performance of duties at various levels of its management. Staff motivation is one of the main means of ensuring the optimal use of resources, as well as the mobilization of existing human resources.
ADJUSTMENT OF THE VECTOR OF WORK OF THE HR-SYSTEM OF THE ORGANIZATION DURING THE INTRODUCTION AND DEVELOPMENT OF DIGITAL TECHNOLOGIES
Authors: Mezhevov A. , Suvalov O. 
Published: April 2023

The use of digital technologies in personnel management is a leading competitive advantage in today’s business space. The article examines the impact of the introduction of digital systems on the management of the organization. New features of the behavior of HR specialists of organizations are determined. The directions for improving HR analytics are investigated. It is noted that the introduction of digital technologies leads to the emergence of new and changes in previously solved tasks in the HR system. Digital technologies give HR specialists the opportunity to change their role and raise their status in the organization. The digital technology platforms used in business practice are considered, their advantages are shown. The focus is on promising digital HR practices, such as the use of chatbots and social networks, big data analysis, the use of applications and analytics based on artificial intelligence, the use of cloud technologies in software, the use of machine learning.
FEATURES OF YOUTH EMPLOYMENT IN THE CONTEXT OF DIGITALIZATION OF THE ECONOMY
Authors: Gurova YEkatyerina 
Published: April 2023

Global digitalization, the introduction of digital technologies in almost all spheres of human life, rapidly changing conditions in the labor market pose the task of mastering fundamentally new competencies in a short time and professional self­determination of young people.
Young people in modern conditions are the main socio­demographic group that uses modern digital technologies from early childhood and is able to quickly adapt to their change.
The delayed clearance of Talaromyces marneffei in blood culture may be associated with higher MIC of voriconazole after antifungal therapy among AIDS patients with talaromycosis
Authors: Guo Pengle , Chen Wanshan , Chen Shaozhen , Chen Meijun , Hu Fengyu , Chen Xiejie , Cai Weiping , Tang Xiaoping , Li Linghua 
Published: April 2023

Objectives
This study aimed to investigate the influencing factors of delayed clearance of Talaromyces marneffei (T. marneffei) in blood culture of patients with acquired immune deficiency syndrome (AIDS) complicated with talaromycosis after antifungal therapy.

Methods
The patients with AIDS complicated with talaromycosis were retrospectively enrolled, and divided into two groups according to the blood T. marneffei culture results in two weeks after antifungal therapy. The baseline clinical data were collected and the antifungal susceptibility of T. marneffei was tested.

Results
A total of 190 patients with AIDS and talaromycosis were enrolled, of whom 101 cases remained positive for T. marneffei (Pos-group) while the other 89 cases were negative in blood culture (Neg-group) after two weeks’ antifungal treatment. The Pos-group had a higher baseline Aspartate aminotransferase (AST, 78.5 vs. 105 U/L; P = 0.073) and lower CD4+ T cells level (11 vs. 7 cells/μl; P = 0.061). The percentage of isolates with higher MICs of voriconazole (VOR) and fluconazole (FLU) in the Pos-group were significantly higher than those in the Neg-group (χ2 = 12.623, P < 0.001 and χ2 = 9.356, P = 0.002, respectively). By multivariate logistic regression, the MIC value for VOR was identified as the prognostic variable that may influence the clearance of T. marneffei in blood culture after antifungal therapy among AIDS patients with talaromycosis.

Conclusions
The delayed negative conversion of blood T. marneffei-culture may be associated with some factors especially higher MIC of VOR, indicating the possibility of drug resistance of T. marneffei.
Doing the Time Warp: Strange Temporalities and Musical Theatre, Sarah Taylor Ellis (2022)
Authors: Yates Samuel 
Published: April 2023

Review of: Doing the Time Warp: Strange Temporalities and Musical Theatre, Sarah Taylor Ellis (2022)
London: Methuen Drama, 288 pp.,
ISBN 978-1-35015-172-7, h/bk, $115.00
processo de curricularização da extensão no curso de Educação Física da Universidade do Estado de Minas Gerais (UEMG), Unidade Ibirité
Authors: Novaes Fernanda Abbatepietro , Puchta Diogo Rodrigues 
Published: April 2023

A publicação da Resolução CNE/CES nº 7/2018, que institui as Diretrizes para a Extensão na Educação Superior Brasileira, provocou um incremento no debate sobre o papel da extensão universitária para o cumprimento da função social da Universidade, bem como a necessidade de reformulação dos currículos dos cursos de graduação. Este texto pretende relatar as reflexões e procedimentos adotados pelo curso de Educação Física da Universidade Estadual de Minas Gerais, unidade Ibirité, para o cumprimento da referida resolução. Partimos do entendimento de que a reivindicação de um espaço legítimo para as atividades extensionistas nos currículos implica em refutar o caráter acessório ou assistencialista, muitas vezes dado à extensão, e evidenciar seu potencial de transformação da sociedade e da própria universidade. Ao final, destacamos as perspectivas que vislumbramos para o curso e os desafios que estão colocados.
Cudzoziemiec w polskim świecie. Kreacja podręcznikowego bohatera w kontekście kształcenia świadomości interkulturowej¬ – na przykładzie serii Start
Authors: Badyda Ewa 
Published: April 2023

The article analyses the image of a foreigner, a recurring protagonist in Start, which is a series of contemporary textbooks for teaching Polish as a foreign language for levels A0-A2. The analysis aims to reveal the extent to which his native cultural background, reflected in the social behaviour, habits, preferences and interests, expressed views and emotions, self-awareness of identity, values and reaction to the encounter with Polish culture, is taken into account in the way he is shown, and to what degree this character has been culturally “Polonized”. The authors conclude that the resource presents a rather ethnocentric point of view and, as such, might undermine the teachers’ efforts to develop intercultural awareness among students.
Gruson–Serganova character formulas and the Duflo–Serganova cohomology functor
Authors: Gorelik Maria , Heidersdorf Thorsten 
Published: April 2023

Abstract
We establish an explicit formula for the character of an irreducible finite-dimensional representation of

g
⁢
l
⁢

(

m
|
n

)

\mathfrak{gl}(m|n)

. The formula is a finite sum with integer coefficients in terms of a basis

E
μ

\mathcal{E}_{\mu}

(Euler characters) of the character ring.
We prove a simple formula for the behavior of the “superversion” of

E
μ

\mathcal{E}_{\mu}

in the

g
⁢
l
⁢

(

m
|
n

)

\mathfrak{gl}(m|n)

and

o
⁢
s
⁢
p
⁢

(

m
|

2
⁢
n

)

\mathfrak{osp}(m|2n)

-case under the map

ds

\mathrm{ds}

on the supercharacter ring induced by the Duflo–Serganova cohomology functor

DS

\mathrm{DS}

.
As an application, we get combinatorial formulas for superdimensions, dimensions and

g
0

\mathfrak{g}_{0}

-decompositions for

g
⁢
l
⁢

(

m
|
n

)

\mathfrak{gl}(m|n)

and

o
⁢
s
⁢
p
⁢

(

m
|

2
⁢
n

)

\mathfrak{osp}(m|2n)

.
Development of biopolymers from microbes and their environmental applications
Authors: Nambiar Krishnanjana , P Saravana Kumari , Devaraj Dheeksha , Sevanan Murugan 
Published: April 2023

Abstract
Inventions begin with the invasion of humans and furnish a better livelihood. In some cases, it turns out to be imperative. The environmental issues of using synthetic polymers, including bio-incompatibility, toxicity, high cost, poor hydrophilicity, and pro-inflammatory degradation of byproducts, are increasing the need for and application of eco-friendly, alternative polymeric substances from medicine to biotechnology, which includes the industries of medicine, cosmetics, confectionery, wastewater treatment, etc., as tissue scaffolds, wound dressings, drug packaging material, dermal fillers, moisturising cream, carriers, sun protectants, antiperspirants, and deodorants; gelling agents; stabilisers, emulsifiers, photographic films, etc. Biopolymers are available in different compounds, produced by microbes, plants, and animals, where microbes, for example, Pseudomonas aeruginosa and Kamagataeibacter sucrofermetans, retain these compounds at an exorbitant level, helping them to sustain adverse conditions. Moreover, compared to plant and animal biopolymers, microbial biopolymers are preferred due to their ease of production, design, and processing at an industrial levels. In this regard, polyhydroxyalkanoates (PHA) and poly-3-hydroxybutyrate (PHB) have together attained assiduity for their biodegradable properties and possess similar features as petrochemical-based polymers, commonly synthetic polymers like polyethylene, polypropylene, etc. This attributes to its non-toxic nature, i.e., it behaves eco-friendly by degrading the components through a carbon-neutral energy cycle to carbon dioxide and water, which lessens the dependence on petroleum-based polymers. This chapter contemplates the methods to develop biopolymers from microbes and their environmental applications, focusing on the confiscation of heavy metals, organic dyes or oils, etc.