bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel dual: rod plate system for EOS improves vertebral wedging and permits spinal growth
Authors: Zheng Yang , Zhou Jian , Niu Chunlei , Ye Qibin , Tang Jiazhu , Wang Xinyang , Wang Guanjun 
Published: September 2023

Abstract
Background
To determine whether single-stage, growth-friendly instrumentation with a plate-rod spinal system (PRSS) can substantially correct the deformity of EOS at surgery and continue to rectify the deformity throughout the growth period.

Methods
An observational study of 35 children with EOS treated by PRSS between February 2000 and October 2010 during a mean follow-up of 72 months. The mean age at surgery was 7 years. X-rays were taken preoperatively and postoperatively and at each follow-up. The Cobb angle, the apical vertebral wedge angle (AVWA), remaining rod lengths, maximal thoracic kyphosis and total T1-S1 heights were measured and compared.

Results
Thirty-one patients, 9 boys and 22 girls, with a mean age of 7 years were completed follow-up. The Cobb angle changed from 64° to 36° after initial surgery and 26° at the last follow-up. The mean AVWA was 15° postoperatively and 5° at the last follow-up. The mean rod tail reserve length decreased from 53 mm immediately after surgery to 12 mm at the last follow-up. The mean preoperative maximum thoracic kyphosis was 41° and changed to 35° and 30° postoperatively and at latest follow-up, respectively. The mean preoperative T1–S1 height for all 32 patients was 52 mm acute lengthening and 122 mm of lengthening by the end of follow-up, respectively.

Conclusion
The PRSS provided immediate correction of most of the deformity at surgery and continued to rectify remaining scoliosis during the growth period. AVWA may be a useful method for monitoring the function of the PRSS in EOS.
When two Z-scores meet—analysis of exercise capacity of children and adolescents with Kawasaki disease by a new Z-score model of coronary artery and a new Z-score evaluating peak oxygen consumption
Authors: Tuan Sheng-Hui , Chung Jin-Hui , Chen Guan-Bo , Sun Shu-Fen , Liou I-Hsiu , Li Chien-Hui , Tsai Yi-Ju 
Published: September 2023

Abstract
Background
Coronary artery (CA) Z-score system is widely used to define CA aneurysm (CAA). Children and adolescents after acute stage of Kawasaki disease (KD-CA) have a higher risk of developing CAAs if their CA Z-score ≥ 2.5. Z-score system of peak oxygen consumption (Peak VO2 Z-score) allows comparisons across ages and sex, regardless of body size and puberty. We aimed to compare the exercise capacity (EC) indicated by peak VO2 Z-score during cardiopulmonary exercise testing (CPET) directly between KD-CA with different CA Z-score.

Methods
KD-CA after acute stage who received CPET in the last 5 years were retrospectively recruited. CA Z-score was based on Lambda-Mu-Sigma method. Max-Z was the maximum CA Z-score of different CAs. KD children with Max-Z < 2.5 and ≥ 2.5 were defined as KD-1 and KD-2 groups, respectively. Peak VO2 Z-score was calculated using the equation established based on Hong Kong Chinese children and adolescent database.

Results
One hundred two KD-CA were recruited (mean age: 11.71 ± 2.57 years). The mean percent of measured peak VO2 to predicted value (peak PD%) was 90.11 ± 13.33. All basic characteristics and baseline pulmonary function indices were comparable between KD-1 (n = 87) and KD-2 (n = 15). KD-1 had significantly higher peak VO2 Z-score (p = .025), peak PD% (p = .008), peak metabolic equivalent (p = .027), and peak rate pressure product (p = .036) than KD-2.

Conclusions
KD-CA had slightly reduced EC than healthy peers. KD-CA with Max-Z ≥ 2.5 had significantly lower peak EC than those < 2.5. Max-Z is potentially useful follow-up indicator after acute stage of KD.
Risk of malignant disease in 1-year sepsis survivors, a registry-based nationwide follow-up study
Authors: Hästbacka Johanna , But Anna , Strandberg Gunnar , Lipcsey Miklós 
Published: September 2023

Abstract
Background
Cancer and sepsis share risk factors, and sepsis patients may have impaired immune response and increased morbidity long after intensive care. This study aimed to assess whether sepsis survivors are at increased risk for cancer. Our objective was to assess the incidence of new cancer in 1-year sepsis survivors and test the hypothesis that it is higher than that of the general population.

Methods
We obtained data on ICU admissions of adult patients from Swedish Intensive care registry (SICR) from 2005 to 2017. We included patients with an explicit ICD-10 code for sepsis for the primary ICU admission. We obtained data on cancer diagnoses (2001–2018), death (2005–2018) and emigration (2005–2018) from Cancer and Cause of death and National Patient Registry databases of the National Board of Health and Welfare; age and sex-specific cancer incidence rates in Sweden from NORDCAN registry from 2006 to 2018. One-year survivors formed the final cohort, that was followed for new cancer diagnoses until death, emigration, or end of 2018, whichever came first. The main outcome measure was standardized incidence rate ratio (SIR) to compare the incidence of cancer in 1-year sepsis survivors to that in the general population (NORDCAN). We also performed several sensitivity analyses.

Results
In a cohort of 18,550 1-year survivors, 75,427 person years accumulated during a median follow-up (FU) of 3.36 years (IQR 1.72–5.86), 6366 (34.3%) patients died, and 1625 (8.8%) patients were diagnosed with a new cancer after a median FU of 2.51 (IQR 1.09–4.48) years. The incidence ratio of any new cancer over the whole FU was 1.31 (95% CI 1.23–1.40) for men and 1.74 (95% CI 1.61–1.88) for women. The difference in incidence rates persisted in several sensitivity analyses. The SIRs were highest in cancers of gastrointestinal tract, genital organs, and skin.

Conclusion and relevance
Compared to general population, incidence of cancer is increased in 1-year sepsis survivors. Variation in the findings depending on follow-up time suggests that factors other than sepsis alone are involved. Surveillance for malignant disease may be warranted in sepsis survivors.

Graphical abstract
Novel endolysin LysMP for control of Limosilactobacillus fermentum contamination in small-scale corn mash fermentation
Authors: Patel Maulik H. , Lu Shao-Yeh , Liu Siqing , Skory Christopher D. 
Published: September 2023

Abstract
Background
Traditional bioethanol fermentation industries are not operated under strict sterile conditions and are prone to microbial contamination. Lactic acid bacteria (LAB) are often pervasive in fermentation tanks, competing for nutrients and producing inhibitory acids that have a negative impact on ethanol-producing yeast, resulting in decreased yields and stuck fermentations. Antibiotics are frequently used to combat contamination, but antibiotic stewardship has resulted in a shift to alternative antimicrobials.

Results
We demonstrate that endolysin LysMP, a bacteriophage-encoded peptidoglycan hydrolase, is an effective method for controlling growth of LAB. The LysMP gene was synthesized based on the prophage sequence in the genome of Limosilactobacillus fermentum KGL7. Analysis of the recombinant enzyme expressed in E. coli and purified by immobilized metal chelate affinity chromatography (IMAC) showed an optimal lysis activity against various LAB species at pH 6, with stability from pH 4 to 8 and from 20 to 40 °C up to 48 h. Moreover, it retains more than 80% of its activity at 10% ethanol (v/v) for up to 48 h. When LysMP was added at 250 µg/mL to yeast corn mash fermentations containing L. fermentum, it reduced bacterial load by at least 4-log fold compared to the untreated controls and prevented stuck fermentation. In comparison, untreated controls with contamination increased from an initial bacterial load of 1.50 × 107 CFU/mL to 2.25 × 109 CFU/mL and 1.89 × 109 CFU/mL after 24 h and 48 h, respectively. Glucose in the treated samples was fully utilized, while untreated controls with contamination had more than 4% (w/v) remaining at 48 h. Furthermore, there was at least a fivefold reduction in lactic acid (0.085 M untreated contamination controls compared to 0.016 M treated), and a fourfold reduction in acetic acid (0.027 M untreated contamination controls vs. 0.007 M treated), when LysMP was used to treat contaminated corn mash fermentations. Most importantly, final ethanol yields increased from 6.3% (w/v) in untreated contamination samples to 9.3% (w/v) in treated contamination samples, an approximate 50% increase to levels comparable to uncontaminated controls 9.3% (w/v).

Conclusion
LysMP could be a good alternative to replace antibiotics for mitigation of LAB contamination in biofuel refineries.
The influence of selected anthropometric parameters on psychomotor abilities among professional Rugby Union players
Authors: Śliż Maciej , Paśko Wojciech , Dziadek Bartosz , Godek Łukasz , Bliźniak Katarzyna , Gouveia Élvio Rúbio , Przednowek Krzysztof 
Published: September 2023

Abstract
Background
One of the most popular varieties of rugby is Rugby Union, in which a team consists of 15 players. Rugby Union is a full-contact sport, and players must demonstrate strength, endurance, speed and agility. During the match, players participate in multiple physical collisions and tackles, short-duration and high-intensity sprinting efforts. In addition, one of the elements affecting the effectiveness of the player’s game can be the reaction time of the rugby player to the visual stimulus and the ability to read the game and react to the situations on the pitch. The level of psychomotor abilities of a person or a player practising sports can be influenced by various factors, including age, body height, body weight, type of sport practised or level of training. The study aimed to analyse the psychomotor abilities of professional rugby union players, investigate the relationship between the selected anthropometric characteristics and psychomotor abilities, and compare obtained results with the control group.

Methods
The study covered 22 players of the Polish National Team (age: 29.3 ± 5.4) and 27 students in the control group (age: 24.3 ± 3.9). The tests were carried out using the Test2Drive computer system of tests. For psychomotor abilities analysis, four tests were used: Simple Reaction Test, Choice Reaction Time Test, Hand-Eye Coordination Test and Spatial Orientation Test. The statistical analysis compares groups using basic statistical measures, and statistically significant differences between groups were checked. In addition, multiple linear regression was used.

Results
The analysis showed statistically significant differences between the groups in the simple reaction time test and the movement time for the test assessing reaction time with choice and eye-hand coordination. Multiple regression analysis conducted for both groups showed a statistically significant influence of some anthropometric parameters on the examined psychomotor abilities. The calculated multiple regression models had a high fit.

Conclusions
The analysis showed that professional Rugby Union players have shorter movement time than the control group. For reaction time, statistically significant differences were observed only for simple reaction time. Moreover, linear regression analysis showed that body height and weight affect the selected psychomotor abilities.
The why, what and how of preconception care: an exploratory descriptive qualitative study in Karnataka, India
Authors: Narendra Agnita Robert , Kowlgi Ambuja , Patil Gururaj H , N Swaroop , Kar Arin 
Published: September 2023

Abstract
Background
Women’s health and nutrition are key to their reproductive health and are important for optimising pregnancy outcomes. Formation of most foetal organs starts soon after conception and much before the woman has her first antenatal visit. The provision of biomedical, behavioural and social interventions to couples to address health, nutrition, behaviour issues and individual environmental risk factors that could contribute to improved maternal and child health outcomes before conception is crucial. Most rural women in India, do not seek pregnancy care before the second trimester because of socio-cultural factors. Therefore, intervening in the preconception period is important. The objective of the study was to explore the challenges and opportunities of implementing preconception care interventions.

Methods
Individual, in-depth, semi-structured interviews (n = 25) were conducted with primary stakeholders (newly married women, newly married men, and family members) in Shorapur taluk of Yadgir district and Devadurga taluk of Raichur district. Thirty-one interviews were conducted with taluk, district, state officials and academicians. This descriptive qualitative study conducted four focus group discussions with front-line health workers. The in-depth interviews (IDIs) and Focus-group discussions (FGDs) used separate pre-tested semi-structured interview/discussion guides. Data analysis was carried out using NVivo software using a phenomenological approach with both inductive and deductive analysis.

Results
A strong influence of social and cultural norms shapes healthcare-seeking behaviour at the community level. Poor dietary diversity, lack of awareness, poor literacy levels, work pressure for women, lack of decision-making power and empowerment among women, pressure to conceive early, and gender norms are the roadblocks to successful preconception care programs in the rural Karnataka setting. The stakeholders expressed the need for interventions during the preconception period. The government functionaries recommended several interventions which could be potentially integrated into the existing Reproductive Maternal, Neonatal, Child and Adolescent Health (RMNCH + A) strategy to improve the health and nutrition of women before they conceive.

Conclusion
The study highlights the need for structured interventions during the preconception period to improve maternal health and pregnancy outcomes. The recommendations provided by government functionaries are indicative of the feasibility of integrating interventions in the RMNCH + A strategy.
Influence of the circadian cycle, sex and production stage on the reference values of parameters related to stress and pathology in porcine saliva
Authors: Saco Y. , Peña R. , Matas-Quintanilla M. , Ibáñez-López F. J. , Piñeiro M. , Sotillo J. , Bassols A. , Gutiérrez A. M. 
Published: September 2023

Abstract
Background
The concentration of biomarkers in saliva could be influenced by several factors not related to the specific condition under analyses, which should be considered for proper clinical interpretation. In the present study, the circadian rhythm of C-reactive protein (CRP), haptoglobin (Hp), Pig-MAP, S100A12, Cu, Zn, Adenosine deaminase (ADA), total protein (TP), total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), cortisol and α-amylase in saliva of 20 female and 20 male pigs was investigated. Moreover, the influence of sex and production phase (post-weaning, fattening and finishing) on the concentrations of biomarkers in a total of 414 healthy pigs was studied and the reference intervals for all salivary biomarkers were calculated accordingly.

Results
All parameters except Pig-MAP, OSI and α-amylase varied significantly along the daytime, and most of them peak around early afternoon (13–15 h). The cosinor analysis described the temporal dynamics of circadian rhythms for all parameters. The range values showed differences between male and female pigs in 8 out of the 13 biomarkers, with higher concentrations in females in comparison to male pigs. The influence of the production phase on the salivary concentrations was observed for all the biomarkers. The highest concentrations were observed for Pig-MAP, S100A12 and α-amylase in post-weaning animals, for TP in growing pigs and for OSI in finishing animals. Most of the sex-influenced biomarkers showed the highest concentrations at growing stages with some exceptions such as ADA or Hp that showed the peak at finishing and post-weaning stages respectively.

Conclusions
It is necessary to establish the optimal daytime for routine saliva sampling to avoid circadian variations and for that end, the time interval between 10:00 a.m. to 12:00 a.m. is highly recommended. The factors sex and production phase influence the concentration of biomarkers and should be considered for proper biomarker interpretation. The reference intervals presented here for each salivary biomarker will help to correctly interpret the results of these analytes and contribute to the use of saliva as a non-invasive sample for the diagnosis and monitoring of the health status of swine farms.
Technological innovation for workload allocation in nursing care management: an integrative review
Authors: Galiano Maria Alejandra , Moreno Fergusson Maria Elisa , Guerrero William J. , Muñóz Maria Francisca , Ortiz Basto Germán A. , Cardenas Ramírez Juan Sebastián , Guevara Lozano Maryory , Larraín Sundt Ana 
Published: September 2023

Background: Technology reduces the nursing workload, improve the quality care processes, patient's safety, and avoid staff burnout. Innovative technologies are disrupting healthcare systems by improving the efficiency of processes and management. There is a discussion on the benefits, challenges, and barriers of these technologies and considering human factors of nursing management. Methods: To analyse the nursing workload models, the predictors of nursing burnout and outcomes, the new technologies and its acceptance for nursing care management based on the literature. An integrative literature review is performed. Scopus, Scielo, PUBMED, and CINALH databases were searched to perform an integrative review following PRISMA guidelines. Articles published from January 2016 to December 2020 were included. Quality appraisal was performed using the Crowe Critical Appraisal Tool version 1.4 (CCAT). Two reviewers independently examined the title and abstract for eligibility according to the inclusion and exclusion criteria. Quality appraisal was performed using the Crowe Critical Appraisal Tool version 1.4 (CCAT). Results: Initially 2,818 articles were potentially relevant. After following the PRISMA Guidelines, 35 studies were included in the review. Four themes appeared: Nursing workload models; Predictors of nursing burnout and outcomes; Information technologies and technological means for management; Technology acceptance. Conclusions: Technology has the potential to improve care management by estimating nurse workload in ICUs and non-critical units, but scientific evidence is more detailed in the former type of services. The literature provides insights about the factors that factors and the barriers that promote the technology acceptance and usability. We did not find studies comparing technologies and no scientific evidence proving improvements in care.
Active adults have thicker peripheral muscles and diaphragm: A cross-sectional study
Authors: Shetty Aishwarya , Chandrasekaran Baskaran , Kamath Koustubh , Ravichandran Sneha , Kadavigere Rajagopal , David Leena R , Karuppaya Banumathe , Vijayasarathi Guruprasad , Sugumar Suresh 
Published: September 2023

Background: The association between exercise and muscle build-up is a long-run connection. Whereas limited physical activity doesn't do well with muscle build-up. But how much is that difference in muscle thickness between different levels of physical activity? Aim: To understand this we conducted a cross-sectional study to associate physical activity and sitting time with the muscle thickness of the lower limb and diaphragm. Methods: The research's participants ranged in age from 18 to 35. Out of 91 patients, 30 were found to smoke routinely and 6 had a drinking history after questions concerning lifestyle factors including smoking and drinking were questioned. In terms of occupation, 74.7% of people had an occupation and 25% were unemployed. We acquired ultrasonography for the quadriceps (rectus femoris and vastus intermedialis), soleus muscle, and diaphragm. Participants were divided into groups according to their self-reported levels of physical activity and sitting time based on IPAQ scores. Results: We found that the lower limb muscles have shown statistically significant differences between vigorous physical activity (VPA) and lower physical activity (LPA). We found that the quadriceps muscle(rectus femoris and vastus intermedialis) thickness was 1.3 cm in LPA whereas 2.8 cm in VPA with (p=<0.001) soleus muscle thickness being 1 cm in LPA and 2.2 cm. Conclusions: Physical activity levels are found to be positively related to the peripheral muscle thickness VPA (p=<0.001). Physical activity levels are found to be positively related to peripheral muscle thickness.
Paying lip service: the importance of soft tissues in orthodontics
Authors: Simon Sowmya , Haworth Jennifer , Ireland Anthony 
Published: September 2023

Knowledge of the facial soft tissues is paramount with regard to orthodontic diagnosis, assessment and treatment planning. This paper will describe the relevance of extra- and intra-oral assessment of soft tissues, with a particular focus on the lips, in orthodontic diagnosis, treatment planning and potential treatment effects. CPD/Clinical relevance: Knowledge of the extra-oral and intra-oral soft tissue assessment is important in the planning and execution of orthodontic treatment.
On-chip multifunctional polarizer based on phase change material
Authors: Long YuQian , Fei Yedeng , Xu Yin , Ni Yi 
Published: September 2023

Polarizers are used to eliminate the undesired polarization state and maintain the other one. The phase change material Ge2Sb2Se4Te1 (GSST) has been widely studied for providing reconfigurable function in optical systems. In this paper, based on a silicon waveguide embedded with a GSST, which is able to absorb light by taking advantage of the relatively large imaginary part of its refractive index in the crystalline state, a multifunctional polarizer with transverse electric (TE) and transverse magnetic (TM) passages has been designed. The interconversion between the two types of polarizers relies only on the state switching of GSST. The size of the device is 7.5µm∗4.3µm, and the simulation results showed that the extinction ratio of the TE-pass polarizer is 45.37 dB and the insertion loss is 1.10 dB at the wavelength of 1550 nm, while the extinction ratio (ER) of the TM-pass polarizer is 20.09 dB and the insertion loss (IL) is 1.35 dB. For the TE-pass polarizer, a bandwidth broader than 200 nm is achieved with ER>20dB and IL<2.0dB over the wavelength region from 1450 to 1650 nm and for the TM-pass polarizer, ER>15dB and IL<1.5dB in the wavelength region from 1525 to 1600 nm, with a bandwidth of approximately 75 nm.
Coconut Water as One of the Optional Oral Electrolyte Solutions
Authors: Munir Muzief , Mustadjab I. 
Published: September 2023

In an attempt to overcome mild and moderate dehydration, caused by diarrheal diseases with the outlook of reducing its mortality rate, it seems to be very important to find out many varieties of oral electrolyte solutions which are available in the communities.
Our study was performed to evaluate the effectiveness of salt in half strength of coconut water solution as one of the optional oral electrolyte solutions.
Children under five years of age with diarrhea were used as subjects in this study, and were divided into two groups, i.e. the ooconut water group and the oratrolyte group (Kimia Parma).
The willingness to drink (acceptability)Â·, the frequency of diarrhea and vomiting, the severity of dehydration before and after rehydration, and the symptoms and signs of side-effects such as abdominal cramps and hyperkalemia were recorded.
From this study it is clear that finely ground salt in half strength of coconut water can be used as an optional oral electrolyte solution with satisfactory results and without any harmful effects.