bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Insights Into the Evolution and Demographic History of the SARS-CoV-2 Omicron Variant: Population Genomics Approach
Authors: Garg Kritika M , Lamba Vinita , Chattopadhyay Balaji 
Published: May 2023

Background
A thorough understanding of the patterns of genetic subdivision in a pathogen can provide crucial information that is necessary to prevent disease spread. For SARS-CoV-2, the availability of millions of genomes makes this task analytically challenging, and traditional methods for understanding genetic subdivision often fail.

Objective
The aim of our study was to use population genomics methods to identify the subtle subdivisions and demographic history of the Omicron variant, in addition to those captured by the Pango lineage.

Methods
We used a combination of an evolutionary network approach and multivariate statistical protocols to understand the subdivision and spread of the Omicron variant. We identified subdivisions within the BA.1 and BA.2 lineages and further identified the mutations associated with each cluster. We further characterized the overall genomic diversity of the Omicron variant and assessed the selection pressure for each of the genetic clusters identified.

Results
We observed concordant results, using two different methods to understand genetic subdivision. The overall pattern of subdivision in the Omicron variant was in broad agreement with the Pango lineage definition. Further, 1 cluster of the BA.1 lineage and 3 clusters of the BA.2 lineage revealed statistically significant signatures of selection or demographic expansion (Tajima’s D<−2), suggesting the role of microevolutionary processes in the spread of the virus.

Conclusions
We provide an easy framework for assessing the genetic structure and demographic history of SARS-CoV-2, which can be particularly useful for understanding the local history of the virus. We identified important mutations that are advantageous to some lineages of Omicron and aid in the transmission of the virus. This is crucial information for policy makers, as preventive measures can be designed to mitigate further spread based on a holistic understanding of the variability of the virus and the evolutionary processes aiding its spread.
Comparison of Reporting and Transparency in Published Protocols and Publications in Umbrella Reviews: Scoping Review
Authors: Zhao Liang , Shen Caiyi , Liu Ming , Zhang Jiaoyan , Cheng Luying , Li Yuanyuan , Yuan Lanbin , Zhang Junhua , Tian Jinhui 
Published: May 2023

Background
Inconsistencies between a protocol and its umbrella review (UR) may mislead readers about the importance of findings or lead to false-positive results. Furthermore, not documenting and explaining inconsistencies in the UR could reduce its transparency. To our knowledge, no study has examined the methodological consistency of the protocols with their URs and assessed the transparency of the URs when generating evidence.

Objective
This study aimed to investigate the inconsistency of protocols with their URs in the methodology and assess the transparency of the URs.

Methods
We searched medical-related electronic databases from their inception to January 1, 2022. We investigated inconsistencies between protocols and their publications and transparencies in the search strategy, inclusion criteria, methods of screening and data extraction, quality assessment, and statistical analysis.

Results
We included 31 protocols and 35 publications. For the search strategy, 39 inconsistencies between the protocols and their publications were found in 26 of the 35 (74%) URs, and 16 of these inconsistencies were indicated and explained. There were 84 inconsistencies between the protocols and their URs regarding the inclusion criteria in 31 of the 35 (89%) URs, and 29 of the inconsistencies were indicated and explained. Deviations from their protocols were found in 12 of the 32 (38%) URs reporting the methods of screening, 14 of the 30 (47%) URs reporting the methods of data extraction, and 11 of the 32 (34%) URs reporting the methods for quality assessment. Of the 35 URs, 6 (17%) were inconsistent with their protocols in terms of the tools for quality assessment; one-half (3/6, 50%) of them indicated and explained the deviations. As for the statistical analysis, 31 of the 35 (89%) URs generated 61 inconsistencies between the publications and their protocols, and 16 inconsistencies were indicated and explained.

Conclusions
There was a high prevalence of inconsistencies between protocols and publications of URs, and more than one-half of the inconsistencies were not indicated and explained in the publications. Therefore, how to promote the transparency of URs will be a major part of future work.
Referring Adolescent Primary Care Patients to Single-Session Interventions for Anxiety and Depression: Protocol for a Feasibility Study
Authors: Eyllon Mara , Dalal Michelle , Jans Laura , Sotomayor Ian , Peloquin Gabrielle , Yon James , Fritz Rochelle , Schleider Jessica 
Published: May 2023

Background
Despite the growing prevalence of depression and anxiety among adolescents, fewer than half access appropriate mental health care. Single-session interventions (SSIs) for depression and anxiety offered in primary care are a promising approach to bridging the treatment gap.

Objective
We aimed to implement a clinical workflow for primary care and behavioral health providers to refer patients aged 13 to 17 years with mild to moderate depression and anxiety symptoms to Project YES (Youth Empowerment and Support), an open-access SSI platform, in a large group medical practice with an integrated behavioral health department.

Methods
Pediatric primary care and integrated behavioral health providers will be educated on the benefits of Project YES for adolescent anxiety and depression and trained in a workflow integrated within the electronic health record system, Epic, to refer patients during well-child visits and pediatric behavioral health visits. Patients with mild to moderate internalizing symptoms based on the 17-item Pediatric Symptom Checklist or youth Pediatric Symptom Checklist will be invited to try an SSI through Project YES. We will examine provider uptake and perceptions of acceptability, feasibility, and appropriateness over time.

Results
The rollout will take place between November 2022 and May 2023, when outcomes will be evaluated. Data analysis and manuscript writing are anticipated to be completed during the summer of 2023.

Conclusions
SSIs such as those available through Project YES have the potential to provide low-cost, evidence-based mental health treatment to adolescents with mild to moderate depression and anxiety. If deemed feasible and acceptable, providing SSIs in primary care settings could significantly improve access to mental health care without taxing pediatric primary care and behavioral health providers.

International Registered Report Identifier (IRRID)
DERR1-10.2196/45666
Aprovechamiento de la quinua cultivada en Cundinamarca: evaluación de las propiedades fisicoquímicas de una bebida fermentada con extracto de quinua, lactosuero y pulpa de mango
Authors: Cañón Rodríguez Daniel Felipe , Benavides Guevara Ruth Mary , Rodríguez González Ibeth , Inampues Charfuelan Mary Lucia 
Published: May 2023

The objective of this study was to evaluate the physicochemical characteristics and sensory acceptance of a fermented beverage with whey, quinoa, and mango. The evaluation was carried out on two quinoa extracts and three treatments with different inclusion percentages. It was found that the physicochemical characteristics for treatment 1 and 2 (T1 and T2) do not comply with the Colombian Technical Standards - NTC 805 after 21 hours of fermentation, while treatment 3 (T3), reached the physicochemical parameters established by the regulations and agrees with the values reported by other studies after 4 hours and 30 minutes of fermentation. Subsequently, an affective sensory analysis was performed on the samples from treatment 3 (T3), and it was found that formulation 2 (F2) obtained a higher evaluation than the control sample (F1) and formulation 3 (F3) according to the score obtained on the hedonic scale evaluated by 28 consumers. The selected beverage had the following composition: protein (3.35 ± 0.000%), titratable acidity (0.77 ± 0.016% lactic acid), pH (4.58 ± 0.011), fat (2.00 ± 0.000%) and concentration of total solids (17.57 ± 0.208°Brix), this nutritional composition shows superior characteristics to other studies carried out by achieving a higher percentage of protein and lower fat content. Furthermore, the fermented beverage met the microbiological requirements established by the NTC 805 regulations.
Reuse and Recycle: Infusing Practice-Driven Cases with New Life through New Technologies
Authors: Gray Joy , Lee Lorraine 
Published: May 2023

ABSTRACT
This paper takes the perspective of enhancing data analytics skills and technology agility in the accounting curriculum by repurposing existing practice-driven cases with new tools and technologies. Through a brief literature review of existing recommendations from academics and practice, we identify current dominant data analytics tools. We then examine the data analytics teaching cases available from practice, specifically those from the Big 4-sponsored foundations. We propose a methodology for instructors to infuse existing cases with updated technology and tools to provide students with comprehensive learning opportunities and encourage technology agility. We provide an example of how this can be done by updating an existing case from the EY Academic Resource Center, integrating Excel and Access with Alteryx, Tableau, and Python.
Management Accounting 4.0: The Future of Management Accounting
Authors: Dai Jun , Vasarhelyi Miklos A. 
Published: May 2023

ABSTRACT
Recent advances in technology have motivated and facilitated a revolution in the manufacturing domain, named “Industry 4.0.” Industry 4.0 significantly changes the manufacturing paradigm by linking the physical world with its virtual model, enabling communications among machines, enhancing collaborations across the value creation chain, and increasing intelligence in the manufacturing process. Those changes are also expected to dramatically influence current business models and impact the management accounting domain. The profession may adjust existing procedures to adapt to these changes or invent novel approaches to improve analyses and decision-making, and will likely become more intelligent and automated. This paper explores a new management accounting paradigm: Management Accounting 4.0 using the organizing principles of accounting information systems meta-theory model. We further establish a roadmap toward the new paradigm from the perspectives of vision, strategy approach, requirements, and priority areas.
Through the Looking Glass: Observations on Experimental Management Accounting Research
Authors: Tan Hun-Tong 
Published: May 2023

ABSTRACT
In this commentary, I offer some observations about the state of experimental management accounting research. I discuss the scope of management accounting research, the current focus of experimental management accounting research, and the need for management accounting research to take into account the distinctive features of the accounting setting. I also make a call for attention to be paid to task, participant, and environmental characteristics in identifying and designing management accounting experiments.
PEMANFAATAN LIMBAH CANGKANG KERANG SEBAGAI CENDERAMATA WISATA DI KELURAHAN TOBOLOLO KOTA TERNATE
Authors: Abubakar Salim , Abdul Kadir Masykhur , Wibowo Eko S. , Subur Riyadi , Susanto Adi Noman , Rina Rina , Sunarti Sunarti , Abubakar Yuyun , Sabar Mesrawaty , Widiyanti Sri Endah Widiyanti , Salim Fajria Dewi 
Published: May 2023

Pemanfaatan cangkang kerang selain untuk menambah nilai ekonomis produk juga sekaligus untuk menjaga kelestarian lingkungan. PKM ini dilakukan dengan tujuan pemberdayaan masyarakat untuk mengolah dan memanfaatkan potensi limbah cangkang kerang menjadi produk seni kerajinan kreatif yang dapat dijadikan sebagai cendaramata wisata. Luaran PKM adalah produk kerajinan berupa kotak tissue, bros, gantungan kunci, lonceng angin. Metode yang digunakan dalam memfasilitasi peningkatan ketrampilan pemanfaatan limbah cangkang kerang sebagai produk cendramata wisata yaitu metode ceramah dan metode praktek. Kegiatan pelatihan ini berhasil karena antusiasme peserta begitu besar dalam menekuni keterampilan seni kerajinan produk cendramata wisata. Produk yang dihasilkan berupa box tissue, lonceng angina, gantungan kunci dan bros. Kelompok “Ori Ma Fala” yang sudah terbentuk berguna untuk meningkatkan keterampilan dan kreativitas perajin serta dapat mengembangkan seni kerajinan kerang khususnya di Kelurahan Tobololo Kecamatan Ternate Barat Kota Ternate dan dalam rangka keberlanjutan kegiatan pelatihanTerbentuknya kelompok wirausaha “Mari Rasa Kreatif” dalam rangka keberlanjutan kegiatan pelatihan.
Daily gabapentin improved behavior modification progress and decreased stress in shelter cats from hoarding environments in a double-blind randomized placebo-controlled clinical trial
Authors: Eagan Bailey H. , van Haaften Karen , Protopopova Alexandra 
Published: May 2023

Abstract

OBJECTIVE
To evaluate the impact of daily gabapentin on behavior modification progression and signs of stress in fearful shelter cats from hoarding environments.

ANIMALS
37 cats (32 met inclusion criteria).

PROCEDURES
Healthy fearful cats were entered into group (1) gabapentin or (2) placebo upon intake. Both groups received daily behavior modification. Cats received 10 mg/kg of liquid gabapentin or placebo every 12 hours. Daily measures of cat stress score, latency to emerge from hiding, general in-shelter behavior, and urine suppression were collected. Results were analyzed on an intention-to-treat and per-protocol basis (including only cats that received > 75% of their doses). Post-adoption surveys assessed cat social behavior.

RESULTS
Of 32 fearful cats, 28 (87.5%) graduated from the behavior modification program in a median of 11 days (range, 4 to 51 days). Per-protocol analysis showed that gabapentin predicted quicker behavior modification progression and lower cat stress score, latency to emerge, and urine suppression compared to placebo. Median time to graduation was reduced by half with gabapentin. Intention-to-treat analysis showed that gabapentin predicted a lower cat stress score and latency to emerge. No differences were observed between groups for general in-shelter behavior. Among limited survey respondents (n = 7), despite showing unsocial behavior in the first week and among unfamiliar people, cats showed social behavior 1 year post-adoption.

CLINICAL RELEVANCE
Daily gabapentin was beneficial in behavior modification progress and reduced signs of stress in shelter cats. Fearful cats from hoarding environments can be successfully treated with behavior modification ± daily gabapentin within an animal shelter.
Advancing antimicrobial stewardship in companion animal veterinary medicine: a qualitative study on perceptions and solutions to a One Health problem
Authors: Lagana Danielle M. , Taylor Daniel D. , Scallan Walter Elaine J. 
Published: May 2023

Abstract

OBJECTIVE
The term antimicrobial stewardship (AMS) is used to describe the coordinated efforts and programs required to sustain the clinical efficacy of antimicrobials and slow the development of antimicrobial resistance. However, companion animal veterinarians are provided with few “cage-side” resources to achieve these goals. The aims of our study were to understand the current perceptions, attitudes, and knowledge of AMS among companion animal veterinarians and to source technology-based solutions that reduce barriers to judicious antimicrobial drug prescribing.

PROCEDURES
6 focus groups were conducted via a teleconference platform. The focus group recordings were transcribed and coded thematically using a grounded theory approach and inductive coding.

RESULTS
A total of 25 companion animal veterinarians participated in 6, 1-hour focus groups. Two themes emerged from the data: (1) Veterinarians feel that AMS is important and understand the principles of AMS, but experience barriers to practicing judicious AMD use principles. (2) Veterinarians agree that technology can promote AMS, but express that a tool needs to support their prescribing decisions, provide accurate and concise stewardship information, and be integrated into the existing workflow.

CLINICAL RELEVANCE
For an AMS technology tool to be successful in improving AMS in companion animal medicine, veterinarians need centralized information on antimicrobial use, improved access to geographical AMR patterns, and communication support with clients and their hospital teams.
PERBEDAAN LUAS PERMUKAAN PROSESUS KONDILARIS ANTARA PENDERITA DAN BUKAN PENDERITA BRUXISM MELALUI RADIOGRAFI PANORAMIK
Authors: Salsabila Farah Nurul , Rikmasari Rasmi , Epsilawati Lusi 
Published: May 2023

ABSTRAKBruxism dapat menyebabkan nyeri pada otot mastikasi atau sendi temporomandibula (TMJ). Beberapa penelitian menunjukan bahwa bruxism dapat memberikan beban besar pada TMJ. Namun, penelitian mengenai efek bruxism pada prosesus kondilaris masih minim. Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan luas permukaan prosesus kondilaris pada penderita bruxism dibandingkan dengan bukan penderita bruxism berdasarkan radiograf panoramik. Penelitian ini merupakan penelitian analitik cross-sectional pada radiograf panoramik penderita dan bukan penderita bruxism di Instalasi Radiologi Rumah Sakit Gigi dan Mulut Universitas Padjadjaran (RSGM Unpad). Kelompok bruxism terdiri dari 24 subjek sementara kelompok bukan penderita bruxism terdiri dari 20 subjek. Luas permukaan prosesus kondilaris diukur menggunakan software ImageJ. Hasil penelitian dianalisis menggunakan independent t-test, dan chi-squared test. Reliabilitas ditentukan menggunakan intra-class correlation coefficient. Penelitian ini mendapatkan rata-rata luas permukaan prosesus kondilaris pada penderita bruxism di regio kanan dan kiri adalah 201,38 39.36 mm dan 191,05 41,90 mm. Pada kelompok bukan penderita bruxism, rata-ratanya adalah 251,35 49,52 mm dan 234,34 43,86 mm di regio kanan dan kiri Penelitian ini menemukan rata-rata luas permukaan prosesus kondilaris pada pasien bruxism lebih kecil dari bukan penderita bruxism tetapi perbedaannya tidak signifikan. Selain itu, perbedaan luas permukaan tidak terikat dengan kondisi bruxism.ABSTRACTBruxism can cause pain in the masticatory muscles and the temporomandibular joint (TMJ). Studies have shown that bruxism can exert large load on the TMJ. However, research on the effects of bruxism on the condylar process is still rare. This study aims to determine whether there is a difference in the surface area of the condylar process in patients with bruxism compared to patients without bruxism based on panoramic radiographs. This was a cross-sectional analytic study conducted on panoramic radiographs of bruxism and non-bruxism patient at the Radiology Unit in Rumah Sakit Gigi dan Mulut Universitas Padjadjaran (RSGM UNPAD). The bruxism group consisted of 24 subjects, while the non-bruxism group consisted of 20 subjects. Condylar surface area was measured using ImageJ software. The results were analyzed with independent t-test and chi-squared test. Reliability was determined using intra-class correlation coefficient. The average surface area of the right and left condylar process in bruxism patients was 201.38 ± 39.36 mm and 191.05 ± 41.90 mm. In non-bruxism patients, the mean surface area was 251.35 ± 49.52 mm and 234.34 ± 43.86 mm in the right and left region. This study found that the average surface area of condylar process in bruxism patients was smaller than non-bruxism patients. but the difference was not significant. In addition, the difference in surface area was not related to the condition of bruxism.
Diálogo deliberativo sobre eutanasia en niñas, niños y adolescentes. Precuela del Cabildo Ciudadano llevado a cabo en Colombia
Authors: Pinzón-Segura María Camila , Ballesteros-Cabrera Magnolia del Pilar , Aragón-Joya Yefry Andrés , Cajamarca-Loaiza Luisa Fernanda , Roth-Deubel André Noël 
Published: May 2023

Antecedentes:
En Colombia y Latinoamérica no se cuenta con registros publicados de temas abordados desde los metodos del diálogo deliberativo frente a temas de salud sobre la población pediátrica.
Objetivo:
El diálogo deliberativo fue utilizado para deliberar sobre el derecho a la muerte digna en niñas, niños y adolescentes, sus criterios de exclusión, y el marco de acción de los cuidados paliativos pediátricos.
Métodos:
Investigación acción participativa recurriendo a la metodología de dialogos deliberativos.
Resultados:
Redacción de un documento de recomendaciones de Política Pública en torno a la eutanasia en población pediátrica y entrega del mismo al Ministerio de Salud y Protección Social de Colombia días previos a la expedición de la Resolución que reglamentó el derecho a morir con dignidad para esta población; así mismo, las conclusiones de este ejercicio posibilitaron la estructuración de una guía metodológica para la realización de Cabildos Ciudadanos en donde se integra a niñas, niños y adolescentes.
Conclusiones:
el diálogo deliberativo puede constituirse en una alternativa para reemplazar o complementar metodologías de participación empleadas en la construcción de lineamientos y políticas públicas en salud