bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEMAMPUAN MEMBACA SISWA DENGAN METODE REGRESI PROBIT ORDINAL (STUDI KASUS SISWA SD SE-SULAWESI TENGGARA)
Authors: Rasdiansastra Waode , Adi Wibawa Gusti , Abapihi Bahriddin 
Published: April 2023

Keterampilan membaca siswa memiliki peran penting dalam pengembangan diri secara berkelanjutan dan sekaligus sebagai fondasi dalam pendidikan siswa di lembaga formal. Tujuan penelitian ini adalah mengetahui karakteristik pada variabel-variabel kemampuan membaca siswa dan estimasi model probit dari faktor-faktor yang mempengaruhi secara signifikan kemampuan membaca siswa(i) SD di Sulawesi Tenggara dengan menggunakan software SPSS. Penelitian ini menggunakan data kategori bertingkat atau biasa disebut data skala ordinal sebagai variabel dependen dan metode yang digunakan adalah regresi probit ordinal. Hasil analisis menunjukkan bahwa variabel yang signifikan terhadap kemampuan membaca siswa(i) adalah jenis kelamin siswa(i) (X1), mengulang kelas (X3), belajar/membaca di rumah (X4), dan guru kelas pernah memperoleh pelatihan khusus tentang cara mengajar membaca (X11). Uji kesesuaian model menunjukkan bahwa nilai signifikansi artinya model regresi probit ordinal yang terbentuk telah sesuai atau tidak terdapat perbedaan antara hasil pengamatan dengan hasil model prediksi.
What is metacognitive reflection? The moderating role of metacognition on emotional regulation and reflection
Authors: Merkebu Jerusalem , Kitsantas Anastasia , Durning Steven J. , Ma TInglan 
Published: April 2023

IntroductionThis paper explores the trilateral relationship among metacognition, emotional regulation, and reflection under the integrative framework of metacognitive reflection.MethodsData were gathered from undergraduate participants at a large state university on the East Coast (N= 493). The quantitative data were derived from: the Metacognitive Awareness Inventory (MAI), the Self-Reflection and Insight Scale (SR-IS), and the Cognitive Reappraisal Scale (ERQ). Data analysis consisted of structural equation modeling (SEM) in which the associations between latent constructs were tested. Emotional regulation and metacognition were found to be positively and significantly related to the latent construct of reflection.ResultsSEM results indicated that emotional regulation (which emerged as the strongest predictor) together with metacognition predicted 52% of the variance in reflection. Moreover, the latent moderation model showed that metacognition significantly moderated the relationship between emotional regulation and reflection such that emotional regulation was a strong and positive predictor of reflection when students simultaneously showed high levels of metacognition. In contrast, emotional regulation did not significantly predict reflection for students with low levels of metacognition. The alternative model showed that emotional regulation also moderated the relationship between metacognition and reflection such that metacognition contributed to reflection the most when participants simultaneously showed high levels of emotional regulation.DiscussionThese findings suggest the interaction between metacognition and emotional regulation is critical in the gamut of reflection.
Effect of breathing exercises on oxidative stress biomarkers in humans: A systematic review and meta-analysis
Authors: Li Ting-ting , Wang Hong-ying , Zhang Hui , Zhang Ping-ping , Zhang Ming-chen , Feng Hai-yang , Duan Xiao-yong , Liu Wen-bo , Wang Xiao-wen , Sun Zhong-guang 
Published: April 2023

BackgroundBreathing exercises improve oxidative stress in healthy young adults and patients with diabetes, hypertension, and chronic obstructive pulmonary disease. Furthermore, the mechanism of respiratory intervention is controversial. Therefore, in this meta-analysis, we aimed to systematically evaluate the effects of breathing exercises on oxidative stress biomarkers in humans and provide evidence for the clinical application of breathing exercises.MethodsThe Embase, PubMed, Cochrane Library, Web of Science, CNKI, and WANFANG databases were searched for studies about the effects of breathing exercises on human oxidative stress levels, with no restraints regarding time, race, or language. The experimental group included various breathing exercises, and the outcome index included malondialdehyde, superoxide dismutase, and glutathione, nitric oxide, vitamin C, or total antioxidant capacity levels from a randomized controlled trial. Data were extracted by more than two authors and reviewed by one author.ResultsTen studies were included from five countries. Data from patients with no disease, chronic obstructive pulmonary disease, hypertension, or diabetes were included. Participants who performed breathing exercises had greater changes in the included biomarkers than those who did not, suggesting that these biomarkers can be used to evaluate oxidative stress after respiratory interventions.ConclusionBreathing exercises increased SOD and GSH activities and decreased MDA content.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337119, identifier CRD42022337119.
Inhibitory effects of Stevioside on Streptococcus mutans and Candida albicans dual-species biofilm
Authors: Guo Mingzhu , Yang Kuan , Zhou Zhifei , Chen Yujiang , Zhou Ziye , Chen Peng , Huang Ruizhe , Wang Xiaojing 
Published: April 2023

IntroductionStreptococcus mutans is the most prevalent biofilm-forming pathogen in dental caries, while Candida albicans is often detected in the presence of S. mutans.MethodsWe aimed to evaluate the anti-caries effect of stevioside in medium trypticase soy broth (TSB) with or without sucrose supplementation compared with the same sweetness sucrose and xylitol in a dual-species model of S. mutans and C. albicans, based on planktonic growth, crystal violet assay, acid production, biofilm structural imaging, confocal laser scanning microscopy, and RNA sequencing.ResultsOur results showed that compared with sucrose, stevioside significantly inhibited planktonic growth and acid production, changed the structure of the mixed biofilm, and reduced the viability of biofilm and the production of extracellular polysaccharides in dual-species biofilm. Through RNA-seq, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway impact analysis showed that stevioside decreased sucrose metabolism and increased galactose and intracellular polysaccharide metabolism in S. mutans, and decreased genes related to GPI-modified proteins and secreted aspartyl proteinase (SAP) family in C. albicans. In contrast to xylitol, stevioside also inhibited the transformation of fungal morphology of C. albicans, which did not form mycelia and thus had reduced pathogenicity. Stevioside revealed a superior suppression of dual-species biofilm formation compared to sucrose and a similar anti-caries effect with xylitol. However, sucrose supplementation diminished the suppression of stevioside on S. mutans and C. albicans.ConclusionsOur study is the first to confirm that stevioside has anticariogenic effects on S. mutans and C. albicans in a dual-species biofilm. As a substitute for sucrose, it may help reduce the risk of developing dental caries.
Correlation between dietary patterns and cognitive function in older Chinese adults: A representative cross-sectional study
Authors: Gou Ruoyu , Qin Jian , Pang Weiyi , Cai Jiansheng , Luo Tingyu , He Kailian , Xiao Song , Tang Xu , Zhang Zhiyong , Li You 
Published: April 2023

ObjectiveThe objective of this study was to investigate the relationship between dietary patterns and cognitive function in older adults (≥60 years old).MethodsFood intake was quantitatively assessed by the Food Frequency Questionnaire (FFQ), and cognitive function was assessed by the Chinese version of the Simple Mental State Examination Scale (MMSE). Four major dietary patterns were identified by the factor analysis (FA) method. The relationship between dietary patterns and cognitive function was evaluated by logistic regression.ResultsA total of 884 participants were included in the study. Four dietary patterns (vegetable and mushroom, oil and salt, seafood and alcohol, and oil tea dietary patterns) were extracted. In the total population, Model III results showed that the fourth quartile of dietary pattern factor scores for the vegetable and mushroom pattern was 0.399 and 7.056. The vegetable and mushroom dietary pattern may be a protective factor for cognitive function, with p-value = 0.033, OR (95% CI): 0.578 (0.348, 0.951) in Model III (adjusted for covariates: sex, ethnic, marital, agricultural activities, smoking, drinking, hypertension, diabetes, dyslipidemia, BMI, and dietary fiber). In the ethnic stratification analysis, the scores of dietary pattern factors of the vegetable and mushroom among the Yao participants were 0.333 and 5.064. The Vegetable and mushroom diet pattern may be a protective factor for cognitive function, p-value = 0.012, OR (95% CI): 0.415 (0.206, 0.815).ConclusionThe fourth quartile of the vegetable and mushroom dietary pattern scores showed dose-dependent and a strong correlation with cognitive function. Currently, increasing vegetable and mushroom intake may be one of the effective ways to prevent and mitigate cognitive decline. It is recommended to increase the dietary intake of vegetables and mushroom foods.
Diet-related inflammation increases the odds of multiple sclerosis: Results from a large population-based prevalent case-control study in Jordan
Authors: Alhaj Omar A. , Trabelsi Khaled , Younes Abdallah M. , Shivappa Nitin , Bragazzi Nicola L. , Hebert James R. , Jahrami Haitham A. 
Published: April 2023

BackgroundMultiple sclerosis, a chronic inflammatory disease in young and middle-aged adults, is one of the leading causes of non-traumatic disability in adults. Diet is known to have an important role in the modulating inflammatory processes and influencing molecular pathways.PurposeThis study aims to examine the association of the inflammatory capacity of diet measured by DII with MS in Jordan.MethodsThis prevalent case-control study included participants of both sexes, aged between 20 and 60 years. The cases (n = 541) had a confirmed diagnosis of prevalent Multiple Sclerosis (MS) in the previous 3 years, and controls (n = 607) were apparently healthy individuals matched on sex and age (42 ± 4 years). A validated Arabic food frequency questionnaire (FFQ) was utilized to obtain estimated dietary intake. Dietary data from the FFQ were analyzed using ESHA’s Food Processor® nutrition analysis software, and the results were used to calculate the DII scores. Logistic regression analyses, controlling for covariates such as age, sex, body mass index, and smoking status, were used to measure the association between DII score and MS outcomes.ResultsCases represent a mixed sample of MS phenotypes and controls were comparable on age and sex. However, controls tended to be taller, lighter, had a lower BMI, and had a lower smoking rate. After controlling for age, BMI, sex, and smoking status, there was a consistent increase in MS risk according to DII score, with a 10-fold increase in odds in quartile 4 vs. quartile 1 [ORquartile 4vs1 = 10.17 (95% CI: 6.88; 15.04)]. For each point increase in DII score, there was nearly a doubling of odds [OR1 = 1.75 (95% CI: 1.59; 1.92)]. Individual nutrients and food values aligned according to their contribution to the DII score calculations.ConclusionThe findings of this study, obtained in MS patients with varied illness duration over the previous 3 years, are consistent with an association between the overall inflammatory potential of diet and MS odds. Our findings among MS participants showed a significantly more pro-inflammatory DII scores than age- and sex-matched controls. Our results also suggest that MS group had a diet rich in pro-inflammatory foods and nutrients.
Mode of presentation and performance of serology assays for diagnosing celiac disease: A single-center study in the United Arab Emirates
Authors: Shatnawei Abdullah , AlNababteh Asma H. , Govender Romona Devi , Al-Shamsi Saif , AlJarrah Ammar , Al-Rifai Rami H. 
Published: April 2023

ObjectiveTo characterize patients with celiac disease (CD), examines the clinical spectrum of CD, and evaluate the performance of serologic tests used for CD screening, in the United Arab Emirates (UAE).MethodsMedical charts of patients received at the Digestive Diseases Institute of Cleveland Clinic Abu Dhabi from January 2015 to December 2020 were reviewed. Patients who were screened for four serologic biomarkers (anti-tissue transglutaminase IgA [Anti-tTG-IgA], anti-tissue transglutaminase IgG [Anti-TtG-IgG], anti-deamidated gliadin peptide IgG [Anti-DGP-IgG], and anti-deamidated gliadin peptide IgA [Anti-DGP-IgA]) were included. Histopathology was performed on patients with the seropositive test. Marsh score &gt; 1 considered to confirm CD. Characteristics of the Anti-tTG-IgA seropositive patients were described and that correlated with histopathologically confirmed CD were explored.ResultsOf the 6,239 patients, 1.4, 2.9, 4.7, and 4.9%, were seropositive to Anti-tTG-IgG, Anti-TtG-IgA, Anti-DGP-IgA, and Anti-DGP-IgG, respectively. Overall, 7.7% were seropositive to either of the four biomarkers. Of the biopsy-screened 300 patients, 38.7% (1.9% of the total serologically screened) were confirmed with CD. The mean age of Anti-TtG-IgA seropositive patients was 32.1 ± 10.3 SD years, 72% of them were females, and 93.4% were Emirati. In those patients, overweight (28.7%) and obesity (24.7%) were common while 5.8% of patients were underweight. Anemia prevalence was 46.7%, 21.3% had Gastroesophageal reflux disease (GERD), 7.7% with autoimmune thyroid disease, 5.5% (type 1), and 3.3% (type 2) were diabetic. Vitamin D deficiency was observed in 47.8% of the Anti-TtG IgA seropositive patients. Twelve (10.3%) histopathologically confirmed CD patients were seronegative to Anti-TtG-IgA but seropositive to anti-DGP-IgA and/or Anti-DGP-IgG. Body mass index, GERD, autoimmune thyroid disease, type 1 diabetes, asthma, hemoglobin, and vitamin D concentration, were all correlated with biopsy-confirmed CD (P &lt; 0.05). Compared to the gold-standard biopsy test, Anti-TtG-IgA had the highest sensitivity (89.7%) and specificity (83.7%).ConclusionThree and two of every 100 patients were serologically (anti-tTG-IgA positive) and histopathologically diagnosed with CD, respectively. Although Anti-TtG-IgA is the most sensitive, specific, and commonly used test, one of every ten histopathologically confirmed patients and Anti-tTG-IgA seronegative were seropositive to Anti-DGP. To avoid missing patients with CD, a comprehensive serological investigation covering DGP-IgG/IgA is warranted.
SAA1 identified as a potential prediction biomarker for metastasis of hepatocellular carcinoma via multi-omics approaches
Authors: Li Gang , Shen Qingrong , Xu Haotian , Zhou Ying , Li Cuiping , Li Yasi , He Min 
Published: April 2023

BackgroundMetastasis is the major cause of high recurrence and mortality of hepatocellular carcinoma (HCC). Unfortunately, there are few reports on effective biomarkers of HCC metastasis. Previous studies have reported that SAA1 may be a predictor and prognostic biomarker for multiple malignant tumors. However, the role of SAA1 in HCC has not yet been investigated.MethodsWe applied RNA sequencing and proteomics analysis to investigate the expression landscape of HCC cell lines and patient serum, respectively. SAA1 is a common key gene and listed as a candidate biomarker of HCC metastasis. It was validated in two cell lines, 107 participants serum, and 63 matched HCC and adjacent non-tumorous liver tissues. Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx), and The Cancer Genome Atlas (TCGA) datasets were integrated to explore SAA1 expression among various cell types and organs. The diagnostic and prognostic value of SAA1 in HCC were determined through receiver operating characteristic (ROC) and Kaplan–Meier curves. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) network were constructed for SAA1, as well as for its co−expressed genes. We further analyzed the correlation between SAA1 and co-expression genes.ResultsWe found 7 differentially expressed genes (DEGs) and 14 differentially expressed proteins (DEPs) were related to HCC metastasis. SAA1, a key candidate biomarker, was highly enriched in hepatocytes and liver organ, and it was also highly expressed in HCC cells and the serum and tissues of HCC patients. The results of ROC curve analysis indicated that SAA1 had better predictive values for distinguishing HCC metastasis from non-metastasis. Kaplan-Meier curve analysis revealed that HCC patients with higher SAA1 expression had worse overall survival.ConclusionsOur findings provide new insights into HCC metastasis by identifying candidate gene prediction biomarkers for HCC metastasis.
Comparison between supine and prone patient setup for lumbosacral spinal stereotactic body radiosurgery with CyberKnife
Authors: Li Jun , Kong Xianghui , cheng Cheng , Wang Gong , Zhuang Hongqing , Yang Ruijie 
Published: April 2023

ObjectiveThe aim of this study is to analyze which tracking modality is more suitable for stereotactic body radiosurgery of lumbosacral spinal tumors by comparing prone and supine patient treatment setup.MethodsEighteen patients with lumbosacral spinal tumors were selected. CT simulation was performed in the supine position (fixed with a vacuum cushion) and prone position (fixed with a thermoplastic mask and prone plate), respectively. The plans in the supine and prone positions were designed using the xsight spine tracking (XST) and xsight spine prone tracking (XSPT) modalities, respectively. The dose-volume histogram (DVH) parameters, namely, V100%, D95%, Dmean, conformity index (CI), and heterogeneity index (HI) in planning target volume (PTV), as well as Dmax, D0.1cc, D1cc, and D5cc in the cauda equina and bowel were recorded. The supine plans were simulation plans and were not used for treatment, which were only used to record the alignment errors. The spinal tracking correction errors (alignment error) and correlation errors of the synchrony respiratory model in the prone position were recorded during the treatment. After treatment, the simulation plan of the supine position was implemented and the spinal tracking correction errors were recorded. The parameters of correction error and DVH parameters for the two positions were analyzed using the paired t-test to compare the difference in positioning accuracy and dose distribution. In addition, the correlation errors of the synchrony respiratory model in the prone position were analyzed to evaluate the prediction accuracy of the synchrony model.ResultsFor patient setup, the correction error of the supine position in interior/posterior was (0.18 ± 0.16) mm and the prone position was (0.31 ± 0.26) mm (P&lt; 0.05). The correction error of the supine position in inferior/superior was (0.27 ± 0.24) mm, and the prone position was (0.5 ± 0.4) mm (P&lt; 0.05). The average correlation errors of the synchrony model for left/right, inferior/superior, and anterior/posterior in the prone position were (0.21 ± 0.11) mm, (0.41 ± 0.38) mm, and (0.68 ± 0.42) mm, respectively. For the dose distribution, compared with prone plans, the average CI in supine plans was increased by 4.5% (P&lt; 0.05). There was no significant difference in HI, PTV V100%, D95%, and Dmean between the prone and supine plans. Compared with supine plans, average D1cc and D5cc for the cauda equina was significantly decreased by 4.7 and 15.3% in the prone plan (P&lt; 0.05). For the bowel, average Dmax, D0.1cc, D1cc, and D5cc were reduced by 8.0, 7.7, 5.2, and 26.6% in prone plans (P&lt; 0.05) compared with supine plans.ConclusionCompared with the supine setup, the prone setup combined with XSPT modality for the lumbosacral spinal stereotactic body radiosurgery can spare the bowel and cauda equina of the middle and low dose irradiation, and decrease the number of beams and monitor units.
Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats
Authors: Cerrah Serkan , Ozcicek Fatih , Gundogdu Betul , Cicek Betul , Coban Taha Abdulkadir , Suleyman Bahadir , Altuner Durdu , Bulut Seval , Suleyman Halis 
Published: April 2023

Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and inflammatory processes. Carvacrol is a monoterpenic phenol with antioxidant and anti-inflammatory properties.Aims: To determine the effects of carvacrol on oxidative liver injury induced by acrylamide administration in rats.Methods: Rats were divided into three groups of six animals each: healthy group acrylamide group (ACR), and acrylamide + carvacrol group (TACR). First, carvacrol (50 mg/kg) was administered intraperitoneally to the CACR group. One hour later, acrylamide (20 mg/kg) was given orally to the ACR and CACR groups. This procedure was performed for 30 days, after which the animals were sacrificed. The malondialdehyde (MDA) and total glutathione (tGSH) levels, total oxidant (TOS) and total antioxidant status (TAS), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and nuclear factor kappa b (NF-κB) were measured in the excised liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in blood serum samples. Liver tissues were also examined histopathologically.Results: In the ACR group, malondialdehyde, TOS, ALT, AST levels, and NF-κB, IL-1β, and TNF-α levels were found to be high, and tGSH and total antioxidant status levels were low. In addition, diffuse degenerative changes and necrosis in hepatocytes, and moderate inflammation in the portal region were detected in the liver tissues of the ACR group. While carvacrol prevented the biochemical changes induced by acrylamide, it also alleviated the damage in the histological structure.Conclusion: Carvacrol may be used for liver damage caused by acrylamide.
Awareness, use, and need of smart care for older adults: A comparative study based on a survey in Macao, China
Authors: Lou Shiyan , Liu Hong 
Published: April 2023

Introduction:With population aging, taking care of the older adults has become a challenge for many countries and regions, and smart care for older adults is considered as a solution to this problem. Need is an important factor that determines whether the model of smart care for older adults can be efficiently promoted and ultimately help in effective senior care.Methods:Based on a survey among older adults and their caregivers in Macao, this paper conducted comparative and correlation studies on the awareness, use, and need of smart care goods and services for older adults.Results:Differences appeared among the groups based on the different categories and items of goods and services. The respondents’ awareness, use, and need of smart senior care were generally low, and levels were lower among older adults than among caregivers; older adults were more concerned about spiritual needs, while the caregivers were more concerned about the health and safety of older adults. Correlation studies showed that awareness of smart senior care was positively related to its use, and these two variables were positively correlated to the need for smart senior care.Implications:This paper fills in the research gap on the need for smart senior care and can help to promote matching supply and demand to enhance the development of the smart senior care industry.