bluuebunny/crossref_metadata_2025_split huggingface dataset:
The microcopepod family Oncaeidae: state of knowledge and perspectives
Authors: Böttger-Schnack Ruth , Schnack Dietrich 
Published: July 2023

AbstractSince the discovery of the first oncaeid copepod described by Philippi in 1843 as Oncaea venusta, great progress has been achieved regarding the morphological/descriptive taxonomy of the microcopepod family Oncaeidae, occurring in all great oceans and all depth layers of the ocean. The species diversity of this family is still underestimated and the ecological role of oncaeids within the marine ecosystem is not yet well understood, but the life strategy appears to be fundamentally different from most other pelagic microcopepod families. The present paper aims at a comprehensive review of the current state of knowledge of this microcopepod family, including taxonomic and phylogenetic issues, questions of species identification, specific morphological and molecular genetic characteristics, information on regional and vertical distribution and abundance, motion behaviour, feeding and food relationships, reproduction aspects, biomass and elemental composition, respiration and metabolic rates. Relevant open questions are highlighted, and examples are given of shortcomings and high uncertainties in results of current attempts to include oncaeid copepods in various aspects of global marine ecosystem studies. It is concluded that continued support of taxonomic research is required for Oncaeidae and other small copepod species, based on an integrated approach of morphological and molecular genetic methods and user-friendly regional identification keys, to allow an adequate consideration of oncaeids in advanced ecological studies and to achieve a better understanding of the ecological role of this abundant microcopepod family in marine ecosystems.
The Added Diagnostic Value of Transcatheter CT Hepatic Arteriography for Intraprocedural Detection of Previously Unknown Colorectal Liver Metastases During Percutaneous Ablation and Impact on the Definitive Treatment Plan
Authors: van der Lei Susan , Opperman Jip , Dijkstra Madelon , Kors Nikita , Boon Rianne , van den Bemd Bente A. T. , Timmer Florentine E. F. , Nota Irene M. G. C. , van den Bergh Janneke E. , de Vries Jan J. J. , Scheffer Hester J. , Geboers Bart , Neuss Timothy , Schouten Evelien , Lissenberg-Witte Birgit I. , Puijk Robbert S. , Meijerink Martijn R. 
Published: July 2023

Abstract
Purpose
This study assessed the diagnostic value of CT hepatic arteriography (CTHA) for the intraprocedural detection of previously unknown colorectal liver metastases (CRLM) and the impact on the definitive treatment plan.

Materials and Methods
All patients treated with CTHA-guided percutaneous ablation for CRLM between January 2012 and March 2022 were identified from the Amsterdam Colorectal Liver Met Registry (AmCORE). Radiology reports of the ablative procedure and follow-up imaging were reviewed to see if (a) previously unknown CRLM were detected intra-procedurally and if (b) new CRLM, potentially missed on CTHA, appeared within 6 months following the procedure; three abdominal radiologists re-reviewed the baseline CTHA scans of these patients with early recurrence. To ratify immediate ablations of concomitantly detected CRLM, the upper limit of false positives was predefined at 10%.

Results
One hundred and fifty-two patients were included. With CTHA, a total of 17 additional tumours in 15 patients were diagnosed and treated immediately, two representing disappeared tumours following systemic chemotherapy. Compared to the conventional contrast-enhanced (ce)CT, ceMRI and 18F-FDG PET-CT, adding CTHA was superior for the detection of CRLM (P < .001). Within 12 months of follow-up 121, new CRLM appeared in 49/152 patients (32.2%); retrospective blinded assessment revealed 56 to already be visible on the baseline CTHA scan (46%); four lesions without substrate on follow-up scans were considered false positives (n = 4/60; 7%). Arterial ring enhancement was the most frequently reported imaging characteristic (n = 45/60; 75%).

Conclusion
The subsequent use of CTHA has added value for the detection of previously unknown and vanished CRLM. Taking into account the low number of false positives (7%) and the favourable safety profile of percutaneous ablation, we believe that immediate ablation of typical ring-enhancing supplementary tumours is justified and sufficiently validated.

Level of Evidence
Level 3; individual cross-sectional study with consistently applied reference standard and blinding.
The graft-versus-leukemia effect of prophylactic donor lymphocyte infusions after allogeneic stem cell transplantation is equally effective in relapse prevention but safer compared to spontaneous graft-versus-host disease
Authors: Stadler Michael , Hambach Lothar , Dammann Elke , Diedrich Helmut , Kamal Haytham , Hamwi Iyas , Schultze-Florey Christian , Varvenne Michael , Ehrlich Steve , Buchholz Stefanie , Koenecke Christian , Beutel Gernot , Weissinger Eva M. , Krauter Jürgen , Eder Matthias , Hertenstein Bernd , Ganser Arnold 
Published: July 2023

AbstractTherapeutic donor lymphocyte infusions (tDLI) are used to reinforce the graft-versus-leukemia (GvL) effect in relapse after allogeneic stem cell transplantation (alloSCT). In contrast, the role of prophylactic DLI (proDLI) in preventing leukemia relapse has been less clearly established, although supported by retrospective, case-control, and registry analyses. We report a prospective, monocentric, ten year cohort of patients with high risk acute leukemias (AL) or myelodysplasia (MDS) in whom proDLI were applied beyond day +120 post alloSCT to compensate for lack of GvL.272 consecutive allotransplanted AL or MDS patients in complete remission and off immunosuppression at day +120 were stratified according to the prior appearance of relevant GvHD (acute GvHD °II-IV or extensive chronic GvHD) as a clinical indicator for GvL. Escalating doses of unmodified proDLI were applied to 72/272 patients without prior relevant GvHD. Conversely, 157/272 patients with prior spontaneous GvHD did not receive proDLI, nor did 43/272 patients with contraindications (uncontrolled infections, patient refusal, DLI unavailability).By day 160-landmark analysis (median day of first DLI application), proDLI recipients had significantly higher five-year overall (OS) and disease free survival (DFS) (77% and 67%) than patients with spontaneous GvHD (54% and 53%) or with contraindications (46% and 45%) (p=0.003). Relapse incidence for patients with proDLI (30%) or spontaneous GvHD (29%) was significantly lower than in patients with contraindications (39%; p=0.021). With similar GvHD incidence beyond day +160, non-relapse mortality (NRM) was less with proDLI (5%) than without proDLI (18%; p=0.036).In conclusion, proDLI may be able to compensate for lack of GvL in alloSCT recipients with high risk AL or MDS.
Programmed death-ligand 1 (PD-L1) expression in primary gastric adenocarcinoma and matched metastases
Authors: Liu Drolaiz H. W. , Grabsch Heike I. , Gloor Beat , Langer Rupert , Dislich Bastian 
Published: July 2023

Abstract
Background
Combination of immunotherapy and chemotherapy is recommended for first line treatment of gastric adenocarcinoma (GC) patients with locally advanced unresectable disease or metastatic disease. However, data regarding the concordance rate between PD-L1 combined positive score (CPS) in primary GC and matched regional lymph node metastasis (LNmet) or matched distant metastasis (Dmet) is limited.

Methods
Tissue microarray sections from primary resected GC, LNmet and Dmet were immunohistochemically stained with anti-PD-L1 (clone SP263). PD-L1 expression was scored separately in tumour cells and immune cells and compared between matched primary GC, LNmet and/or Dmet. CPS was calculated and results for CPS cut-offs 1 and 5 were compared between matched samples.

Results
275 PD-L1 stained GC were analysed. 189 primary GC had matched LNmet. CPS cut-off 1 concordance rate between primary GC and LNmet was 77%. 23 primary GC had matched Dmet but no matched LNmet, CPS cut-off 1 concordance rate was 70%. 63 primary GC had both matched LNmet and matched Dmet, CPS cut-off 1 concordance rate of 67%. CPS cut-off 5 results were similar. The proportion of PD-L1 positive tumour cells increased from primary GC (26%) to LNmet (42%) and was highest in Dmet (75%).

Conclusion
Our study showed up to 33% discordance of PD-L1 CPS between primary GC and LNmet and/or Dmet suggesting that multiple biopsies of primary GC and metastatic sites might need to be tested before considering treatment options. Moreover, this is the first study that seems to suggest that tumour cells acquire PD-L1 expression during disease progression.
Early clinical trial unit tumor board: a real-world experience in a national cancer network
Authors: Weiss L. , Dorman K. , Boukovala M. , Schwinghammer F. , Jordan P. , Fey T. , Hasselmann K. , Subklewe M. , Bücklein V. , Bargou R. , Goebeler M. , Sayehli C. , Spoerl S. , Lüke F. , Heudobler D. , Claus R. , von Luettichau I. , Lorenzen S. , Lange S. , Westphalen C. B. , von Bergwelt-Baildon M. , Heinemann V. , Gießen-Jung C. 
Published: July 2023

Abstract
Purpose
Early clinical trials are the first step into clinical therapies for new drugs. Within the six Bavarian university-based hospitals (Augsburg, Erlangen, Regensburg, Munich (LMU and TU), Würzburg) we have enrolled a virtual network platform for patient discussion.

Methods
The virtual Early Clinical Trial Unit Tumor Board (ECTU Tumor Board) is a secured web-based meeting to evaluate early clinical trial options for patients, where representatives from local ECTUs participate. We retrospectively analyzed patient cases discussed between November 2021 and November 2022.

Results
From November 2021 to November 2022, a total of 43 patients were discussed in the ECTU Tumor Board. Median age at diagnosis was 44.6 years (range 10–76 years). The median number of previous lines of therapies was 3.7 (range 1–9 therapies) including systemic treatment, surgery, and radiation therapy. A total of 27 different tumor entities were presented and 83.7% (36/43) patients received at least one trial recommendation. In total, 21 different active or shortly recruiting clinical trials were recommended: ten antibody trials, four BiTE (bispecific T cell engager) trials, six CAR (chimeric antigen receptor) T-cell trials, and one chemotherapy trial. Only six trials (28.6%) were recommended on the basis of the previously performed comprehensive genetic profiling (CGP).

Conclusion
The ECTU Tumor Board is a feasible and successful network, highlighting the force of virtual patient discussions for improving patient care as well as trial recruitment in advanced diseases. It can provide further treatment options after local MTB presentation, aiming to close the gap to access clinical trials.
Numerical simulation of the extrusion and layer deposition processes in 3D concrete printing with the Particle Finite Element Method
Authors: Rizzieri Giacomo , Ferrara Liberato , Cremonesi Massimiliano 
Published: July 2023

Abstract3D Concrete Printing (3DCP) is a rapidly evolving technology that allows for the efficient and accurate construction of complex concrete objects. In this paper, a numerical modelling approach is presented for the simulation of the printing process of cementitious materials, based on the homogeneous fluid assumption. To cope with the large deformations of the domain and the nonlinearity resulting from the use of a non-Newtonian rheological law, the Navier–Stokes equations are solved in the framework of the Particle Finite Element Method (PFEM). Furthermore, tailored solutions have been formulated and implemented for the time-dependent moving boundary conditions at the nozzle outlet and for the efficient handling of the inter-layer contact in the same PFEM framework. The overall computational cost is decreased by the implementation of an adaptive de-refinement technique, which drastically reduces the number of degrees of freedom in time. The proposed modelling approach is finally validated by simulating the printing process of six rectilinear layers and one multi-layer “wall”. The results show good agreement with the experimental data and provide valuable insights into the printing process, paving the way for the use of numerical modelling tools for the optimization of materials and processes in the field of 3D Concrete Printing.
Correlation of mucosal healing endpoints with long-term clinical and patient-reported outcomes in ulcerative colitis
Authors: Parkes Gareth , Ungaro Ryan C. , Danese Silvio , Abreu Maria T. , Arenson Ethan , Zhou Wen , Ilo Dapo , Laroux F. Stephen , Deng Huiwen , Sanchez Gonzalez Yuri , Peyrin-Biroulet Laurent 
Published: July 2023

Abstract
Background
We evaluated the clinical relevance of achieving histologic endoscopic mucosal improvement (HEMI) and the more stringent target of histologic endoscopic mucosal remission (HEMR) in the phase 3 maintenance trial of upadacitinib for moderately to severely active ulcerative colitis.

Methods
Clinical and patient-reported outcomes were assessed in patients with clinical response after 8- or 16-week upadacitinib induction who received 52-week upadacitinib maintenance treatment. Cross-sectional and predictive analyses evaluated the relationship between HEMR or HEMI at Week 8/16 and Week 52, respectively, and outcomes at Week 52. Adjusted odds ratios (aOR) were derived from logistic regressions for patients achieving HEMR or HEMI without HEMR versus those not achieving HEMI.

Results
Cross-sectional analyses showed that patients with HEMR had greater odds of achieving all clinical and patient-reported outcomes at Week 52 than those not achieving HEMI. In predictive analyses, patients with HEMR at Week 8/16 had significantly greater odds of achieving clinical remission (aOR = 3.6, p = 0.001) and endoscopic remission (aOR = 3.9, p < 0.001) at Week 52 than patients not achieving HEMI and HEMR. For patients achieving HEMI without HEMR, these odds were lower: clinical remission (aOR = 3.2, p < 0.001) and endoscopic remission (aOR = 2.4, p = 0.010). The odds of achieving clinically meaningful improvements in most patient-reported outcomes were directionally similar between HEMI and HEMR, but not statistically different to patients not achieving HEMI. No hospitalizations or surgeries were observed in patients with HEMR at Week 52.

Conclusions
Achievement of HEMR or HEMI is clinically relevant with HEMR being associated with greater likelihood of improvement in long-term clinical and patient-reported outcomes. https://www.clinicaltrials.gov NCT02819635.
Behavioural responses to horizontal vibrations of quasi-2D ideal granular beds: an experimental approach
Authors: Moss J. , Glovnea R. 
Published: July 2023

AbstractIn this experimental study, granular bed response to horizontal vibrations of various frequencies and amplitudes are examined with high-speed imaging. Ideal granular beds consisting of spherical glass beads are horizontally vibrated in a quasi-two-dimensional arrangement, firstly with homogeneous granular media and then with a ternary mixture to explore how bed response deviates with changes to material composition. Phenomena of note are the tendency for the homogeneous material to subdivide into discrete areas of crystalline lattice structures, bounded by non-crystalline lines of bead contacts, labelled in this paper as ‘shear lines’. Shear line failure arises as neighbouring crystalline areas slide relative to one another along their shared non-crystalline border, combining to form one larger crystalline area. Under vibration conditions where particle agitation and relative movement is high, sloshing occurs in the upper bed and triangular granular-gas regions form in the top corners. The ternary mixture also exhibits sloshing at low frequency and large amplitude, but the inhomogeneity of its composition prevents formation of ordered crystalline regions and shear lines, instead promoting low percolation and a jamming effect underneath the sloshing region. Surprisingly strong convective responses are induced in the inhomogeneous bed with more energetic vibrations. From the analysis of shear lines in the homogeneous beds, and of convection in the inhomogeneous beds, comparisons between homogeneous and inhomogeneous bed behaviour are drawn. Results are used to discuss how behavioural response of non-cohesive granular material to horizontal vibrations is ultimately tied to, and changes with, the geometric complexity of the internal packing structure. The concept of ‘geometric compatibility’ between constituent particle species in an inhomogeneous granular medium is proposed as an explanation for the low percolation and strong convective response to vibration.
Graphical abstract
Sexual health in long-term breast cancer survivors: a comparison with female population controls from the HUNT study
Authors: Smedsland Solveig K. , Vandraas Kathrine F. , Falk Ragnhild S. , Horn Julie , Reidunsdatter Randi J. , Kiserud Cecilie E. , Dahl Alv A. , Brekke Mette , Reinertsen Kristin V. 
Published: July 2023

Abstract
Purpose
Sexual health is an important aspect of quality of life. Knowledge concerning sexual health in long-term breast cancer survivors (BCSs) is limited. This study compared sexual health in BCSs 8 years after diagnosis with similarly aged controls and examined the impact of menopausal status at diagnosis and systemic breast cancer treatments on sexual health.

Methods
Women aged 20–65 years when diagnosed with stage I–III breast cancer in 2011–2012 were identified by the Cancer Registry of Norway (n = 2803) and invited to participate in a nationwide survey. Controls were women from the Trøndelag Health Study (HUNT4). Sexual functioning and sexual enjoyment were measured by the EORTC QLQ-BR23 subscales scored from 0 to 100, and sexual discomfort by the Sexual Activity Questionnaire scored from 0 to 6. Linear regression analyses with adjustments for sociodemographic and health-related variables were performed to compare groups. Differences of ≥ 10% of range score were considered clinically significant.

Results
The study samples consisted of 1241 BCSs and 17,751 controls. Sexual enjoyment was poorer (B − 13.1, 95%CI − 15.0, − 11.2) and discomfort higher (B 0.9, 95%CI 0.8, 1.0) among BCSs compared to controls, and larger differences were evident between premenopausal BCSs and controls (B − 17.3, 95%CI − 19.6, − 14.9 and B 1.2, 95%CI 1.0, 1.3, respectively). BCSs treated with both endocrine- and chemotherapy had lower sexual functioning (B − 11.9, 95%CI − 13.8, − 10.1), poorer sexual enjoyment (B − 18.1, 95%CI − 20.7, − 15.5), and more sexual discomfort (B 1.4, 95% 1.3, 1.6) than controls.

Conclusion
Sexual health impairments are more common in BCSs 8 years after diagnosis compared to similar aged population controls. During follow-up, attention to such impairments, especially among women diagnosed at premenopausal age and treated with heavy systemic treatment, is warranted.
A space–time variational method for optimal control problems: well-posedness, stability and numerical solution
Authors: Beranek Nina , Reinhold Martin Alexander , Urban Karsten 
Published: July 2023

AbstractWe consider an optimal control problem constrained by a parabolic partial differential equation with Robin boundary conditions. We use a space–time variational formulation in Lebesgue–Bochner spaces yielding a boundedly invertible solution operator. The abstract formulation of the optimal control problem yields the Lagrange function and Karush–Kuhn–Tucker conditions in a natural manner. This results in space–time variational formulations of the adjoint and gradient equation in Lebesgue–Bochner spaces, which are proven to be boundedly invertible. Necessary and sufficient optimality conditions are formulated and the optimality system is shown to be boundedly invertible. Next, we introduce a conforming uniformly stable simultaneous space–time (tensorproduct) discretization of the optimality system in these Lebesgue–Bochner spaces. Using finite elements of appropriate orders in space and time for trial and test spaces, this setting is known to be equivalent to a Crank–Nicolson time-stepping scheme for parabolic problems. Comparisons with existing methods are detailed. We show numerical comparisons with time-stepping methods. The space–time method shows good stability properties and requires fewer degrees of freedom in time to reach the same accuracy.
Trophic state and potential productivity assessment for Qaroun Lake using spatial techniques
Authors: Mohamed Hagar M. , Khalil Magdy T. , El-Zeiny Ahmed M. , Khalifa Nehad , Kafrawy Sameh B. El , Emam Wiam W. M. 
Published: July 2023

AbstractQaroun Lake is one of the most important Egyptian lakes which, recently, have been exposed to severe degradation in water quality and fish productivity. In this manuscript, Carlson’s trophic state index (CTSI) was used to evaluate the trophic state, while the trophometric index (TMI) was used to assess the potential productivity of Qaroun Lake. The present study is one of the initial attempts to investigate these indices in Qaroun Lake. To achieve this work, an integrated multidisciplinary approach was adopted integrating field investigation, geographic information system, and data analysis. CTSI combines three variables of water quality: chlorophyll-a (CHL-a), total phosphorus (TP), and transparency measured by Secchi disk depth (SDD). The result of overall CTSI showed the hypereutrophic state is represented by 62% and eutrophic state is represented by 38% of the total lake’s area. Moreover, the calculated TMI indicated the average potential productivity value (PP) is 619 t. It can be concluded that the hypereutrophic is the dominant state in Qaroun Lake. The present study recommends the application of TMI model to evaluate and monitor the changes in Qaroun Lake’s potential productivity in response to the changing environmental conditions and other biological pressures (e.g., Isopoda paraside).
Posterior wall thickness of the confluent inferior pulmonary veins measured by left atrial intracardiac echocardiography: implications for catheter ablation
Authors: Negishi Kodai , Okumura Ken , Onishi Fumitaka , Yoshimura Akino , Okamatsu Hideharu , Tsurugi Takuo , Tanaka Yasuaki , Sakai Yoshiro , Nakao Koichi , Sakamoto Tomohiro , Koyama Junjiro , Tomita Hirofumi 
Published: July 2023

Abstract
Background
Confluent inferior pulmonary veins (CIPV) is a rare anatomical variant. There is few evidence in the literature regarding anatomic landmarks consideration to guide radiofrequency application in avoiding complications in the esophagus in CIPV cases.

Methods
Of 986 consecutive patients undergoing atrial fibrillation (AF) ablation from July 2020 to June 2022, seven (0.7%) had CIPV with a common trunk connecting to the LA diagnosed by 3-dimensional contrast-enhanced computed tomography. Using intracardiac echocardiography (ICE) performed from the left atrium (LA), we measured the posterior wall thickness (PWT) of the CIPV adjacent to the esophagus and compared the measurement with the LA posterior wall thickness (LAPWT) at the left inferior PV level of 25 controls without CIPV. For ablation in CIPV patients, each superior PV was individually isolated, and box isolation of CIPV without ablating the CIPV posterior wall was added (tri-circle ablation technique).

Results
The CIPV PWT was 0.7 ± 0.1 mm, while non-CIPV LAPWT was 2.0 ± 0.4 mm (P < 0.001). In the CIPV group, upper and lower portions of the CIPV were both apart from the esophagus (mean distances, 6.7 ± 3.4 mm and 7.9 ± 2.7 mm, respectively). Individual superior PV isolation and box CIPV isolation resulted in complete isolation of all PVs, with no complications. All CIPV patients except one remained AF recurrence-free for 376 ± 52 days.

Conclusions
Although CIPV frequency is low, CIPV PWT is very thin and special care is needed during ablation. A “tri-circle” ablation strategy avoids ablating in the thinnest portion of the posterior wall. Further studies are warranted to assess the safety.