bluuebunny/crossref_metadata_2025_split huggingface dataset:
Axion-like ALPs
Authors: Arias-Aragón Fernando , Quevillon Jérémie , Smith Christopher 
Published: March 2023

Abstract
The Effective Field Theory (EFT) Lagrangian for a generic axion-like particle (ALP) has many free parameters, and leaves quite some freedom for the expected phenomenology. In this work, we set up more constrained EFTs by enforcing true axion-like properties for the ALP. Indeed, though the Peccei-Quinn symmetry of the QCD axion is anomalous, it is so in specific ways, and this shows up as consistency conditions between the gauge boson and fermion couplings. We propose to enforce such conditions, as inspired from the DFSZ and KSVZ scenarios, on the generic ALP EFTs. These truly axion-like ALP EFTs are then particularly well-suited as benchmark scenarios, to be used in the search for ALPs both at colliders and at low-energy experiments.
On the equivalence between SRS and PCO formulations of superstring perturbation theory
Authors: Wang Charles , Yin Xi 
Published: March 2023

Abstract
We establish the equivalence between two formulations of superstring perturbation theory, one based on integration over the supermoduli space of super Riemann surfaces (SRS), the other based on integration over the bosonic moduli space with insertions of picture changing operators (PCO) on the worldsheet and the vertical integration prescription, by showing how the latter arises from a specific construction of the supermoduli integration contour.
Effective description of sub-maximal chaos: stringy effects for SYK scrambling
Authors: Choi Changha , Haehl Felix M. , Mezei Márk , Sárosi Gábor 
Published: March 2023

Abstract
It has been proposed that the exponential decay and subsequent power law saturation of out-of-time-order correlation functions can be universally described by collective ‘scramblon’ modes. We develop this idea from a path integral perspective in several examples, thereby establishing a general formalism. After reformulating previous work on the Schwarzian theory and identity conformal blocks in two-dimensional CFTs relevant for systems in the infinite coupling limit with maximal quantum Lyapunov exponent, we focus on theories with sub-maximal chaos: we study the large-q limit of the SYK quantum dot and chain, both of which are amenable to analytical treatment at finite coupling. In both cases we identify the relevant scramblon modes, derive their effective action, and find bilocal vertex functions, thus constructing an effective description of chaos. The final results can be matched in detail to stringy corrections to the gravitational eikonal S-matrix in holographic CFTs, including a stringy Regge trajectory, bulk to boundary propagators, and multi-string effects that are unexplored holographically.
Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice
Authors: Tseng Hui-Ju , Chen Wen-Chu , Kuo Tien-Fen , Yang Greta , Feng Ching-Shan , Chen Hui-Ming , Chen Tzung-Yan , Lee Tsung-Han , Yang Wen-Chin , Tsai Keng-Chang , Huang Wei-Jan 
Published: March 2023

AbstractPdia4 has been characterized as a key protein that positively regulates β-cell failure and diabetes via ROS regulation. Here, we investigated the function and mechanism of PS1, a Pdia4 inhibitor, in β-cells and diabetes. We found that PS1 had an IC50 of 4 μM for Pdia4. Furthermore, PS1 alone and in combination with metformin significantly reversed diabetes in db/db mice, 6 to 7 mice per group, as evidenced by blood glucose, glycosylated hemoglobin A1c (HbA1c), glucose tolerance test, diabetic incidence, survival and longevity (P < 0.05 or less). Accordingly, PS1 reduced cell death and dysfunction in the pancreatic β-islets of db/db mice as exemplified by serum insulin, serum c-peptide, reactive oxygen species (ROS), islet atrophy, and homeostatic model assessment (HOMA) indices (P < 0.05 or less). Moreover, PS1 decreased cell death in the β-islets of db/db mice. Mechanistic studies showed that PS1 significantly increased cell survival and insulin secretion in Min6 cells in response to high glucose (P < 0.05 or less). This increase could be attributed to a reduction in ROS production and the activity of electron transport chain complex 1 (ETC C1) and Nox in Min6 cells by PS1. Further, we found that PS1 inhibited the enzymatic activity of Pdia4 and mitigated the interaction between Pdia4 and Ndufs3 or p22 in Min6 cells (P < 0.01 or less). Taken together, this work demonstrates that PS1 negatively regulated β-cell pathogenesis and diabetes via reduction of ROS production involving the Pdia4/Ndufs3 and Pdia4/p22 cascades.
Development of a diagnostic tool for product circularity: a redesign approach
Authors: Mesa Jaime A. , González-Quiroga Arturo 
Published: March 2023

AbstractThe design of circular products is gaining relevance among academics, practitioners, and industry as a critical step to face material scarcity, the unsustainability of industrial processes, and excessive waste generation. Therefore, product design is a powerful research field to promote material, component, and product circularity throughout several lifecycles. However, there is a lack of formal methods to measure the circularity of products, especially from the early design stages. Therefore, this paper proposes a diagnostic tool for measuring circularity, identifying potential improvement opportunities, and redesigning interventions in the conceptual design phase. The tool consists of eight single indicators that measure disassemblability, reassemblability, durability, modularity, simplicity, standardization, commonality, relative costs, and the number of secondary functions of products. A case study is presented to validate the tool, considering several improvement scenarios around the 6R strategies. Finally, a list of redesign interventions for each improvement scenario was assembled as a primary output of the proposed tool.
Optimisation of scan duration and image quality in oncological 89Zr immunoPET imaging using the Biograph Vision PET/CT
Authors: van Sluis Joyce , Boellaard Ronald , Dierckx Rudi A. J. O. , van Esch Evelien L. M. , Croes Demi A. , de Ruijter Laura Kist , van de Donk Pim P. , de Vries Elisabeth G. E. , Noordzij Walter , Brouwers Adrienne H. 
Published: March 2023

Abstract

Purpose

Monoclonal antibody (mAb)-based PET (immunoPET) imaging can characterise tumour lesions non-invasively. It may be a valuable tool to determine which patients may benefit from treatment with a specific monoclonal antibody (mAb) and evaluate treatment response. For 89Zr immunoPET imaging, higher sensitivity of state-of-the art PET/CT systems equipped with silicon photomultiplier (SiPM)-based detector elements may be beneficial as the low positron abundance of 89Zr causes a low signal-to-noise level. Moreover, the long physical half-life limits the amount of activity that can be administered to the patients leading to poor image quality even when using long scan durations. Here, we investigated the difference in semiquantitative performance between the PMT-based Biograph mCT, our clinical reference system, and the SiPM-based Biograph Vision PET/CT in 89Zr immunoPET imaging. Furthermore, the effects of scan duration reduction using the Vision on semiquantitative imaging parameters and its influence on image quality assessment were evaluated.

Methods
Data were acquired on day 4 post 37 MBq 89Zr-labelled mAb injection. Five patients underwent a double scan protocol on both systems. Ten patients were scanned only on the Vision. For PET image reconstruction, three protocols were used, i.e. one camera-dependent protocol and European Association of Nuclear Medicine Research Limited (EARL) standards 1 and 2 compliant protocols. Vision data were acquired in listmode and were reprocessed to obtain images at shorter scan durations. Semiquantitative PET image parameters were derived from tumour lesions and healthy tissues to assess differences between systems and scan durations. Differently reconstructed images obtained using the Vision were visually scored regarding image quality by two nuclear medicine physicians.

Results
When images were reconstructed using 100% acquisition time on both systems following EARL standard 1 compliant reconstruction protocols, results regarding semiquantification were comparable. For Vision data, reconstructed images that conform to EARL1 standards still resulted in comparable semiquantification at shorter scan durations (75% and 50%) regarding 100% acquisition time.

Conclusion
Scan duration of 89Zr immunoPET imaging using the Vision can be decreased up to 50% compared with using the mCT while maintaining image quality using the EARL1 compliant reconstruction protocol.
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
Authors: Thomsen Liv Cecilie Vestrheim , Honoré Alfred , Reisæter Lars Anders Rokne , Almås Bjarte , Børretzen Astrid , Helle Svein Inge , Førde Kristina , Kristoffersen Einar Klæboe , Kaada Silje Helland , Melve Guro Kristin , Haslerud Torjan Magne , Biermann Martin , Bigalke Iris , Kvalheim Gunnar , Azeem Waqas , Olsen Jan Roger , Gabriel Benjamin , Knappskog Stian , Halvorsen Ole Johan , Akslen Lars Andreas , Bahn Duke , Pantel Klaus , Riethdorf Sabine , Ragde Haakon , Gjertsen Bjørn Tore , Øyan Anne Margrete , Kalland Karl-Henning , Beisland Christian 
Published: March 2023

AbstractMetastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory microenvironment, while dendritic cells (DCs) activate immune responses through processing of antigens. Immunotherapy combinations could enhance the anti-tumor efficacy. This open-label, single-arm, single-center phase I trial determined the safety and tolerability of combining cryoablation and autologous immature DC, without and with checkpoint inhibitors. Immune responses and clinical outcomes were evaluated. Patients with mCRPC, confirmed metastases and intact prostate gland were included. The first participants underwent prostate cryoablation with intratumoral injection of autologous DCs in a 3 + 3 design. In the second part, patients received cryoablation, the highest acceptable DC dose, and checkpoint inhibition with either ipilimumab or pembrolizumab. Sequentially collected information on adverse events, quality of life, blood values and images were analyzed by standard descriptive statistics. Neither dose-limiting toxicities nor adverse events > grade 3 were observed in the 18 participants. Results indicate antitumor activity through altered T cell receptor repertoires, and 33% durable (> 46 weeks) clinical benefit with median 40.7 months overall survival. Post-treatment pain and fatigue were associated with circulating tumor cell (CTC) presence at inclusion, while CTC responses correlated with clinical outcomes. This trial demonstrates that cryoimmunotherapy in mCRPC is safe and well tolerated, also for the highest DC dose (2.0 × 108) combined with checkpoint inhibitors. Further studies focusing on the biologic indications of antitumor activity and immune system activation could be considered through a phase II trial focusing on treatment responses and immunologic biomarkers.
An SIR model with viral load-dependent transmission
Authors: Della Marca Rossella , Loy Nadia , Tosin Andrea 
Published: March 2023

AbstractThe viral load is known to be a chief predictor of the risk of transmission of infectious diseases. In this work, we investigate the role of the individuals’ viral load in the disease transmission by proposing a new susceptible-infectious-recovered epidemic model for the densities and mean viral loads of each compartment. To this aim, we formally derive the compartmental model from an appropriate microscopic one. Firstly, we consider a multi-agent system in which individuals are identified by the epidemiological compartment to which they belong and by their viral load. Microscopic rules describe both the switch of compartment and the evolution of the viral load. In particular, in the binary interactions between susceptible and infectious individuals, the probability for the susceptible individual to get infected depends on the viral load of the infectious individual. Then, we implement the prescribed microscopic dynamics in appropriate kinetic equations, from which the macroscopic equations for the densities and viral load momentum of the compartments are eventually derived. In the macroscopic model, the rate of disease transmission turns out to be a function of the mean viral load of the infectious population. We analytically and numerically investigate the case that the transmission rate linearly depends on the viral load, which is compared to the classical case of constant transmission rate. A qualitative analysis is performed based on stability and bifurcation theory. Finally, numerical investigations concerning the model reproduction number and the epidemic dynamics are presented.
Optical pressure sensing at MHz rates via collisional line broadening of carbon monoxide: uncertainty quantification in reacting flows
Authors: Nair Anil P. , Minesi Nicolas Q. , Kuenning Nicholas M. , Keller Alex R. , Spearrin R. Mitchell 
Published: March 2023

AbstractAn optical method for high-speed line-of-sight pressure measurements using infrared laser absorption spectroscopy is presented with detailed uncertainty analysis related to thermodynamic and compositional variation in combustion environments. The technique exploits simultaneous sub-microsecond sensing of temperature and mole fraction to extract pressure from collisional line broadening at MHz rates. A distributed-feedback quantum-cascade laser near 5 $$\upmu $$
μ
m in a bias-tee circuit is used to spectrally resolve multiple rovibrational transitions in the P-branch of the fundamental band of carbon monoxide, which may be seeded or nascent to reacting flows. A comprehensive approach for estimating collisional line broadening in complex combustion gas mixtures is presented. Uncertainty is quantified for a wide range of conditions, reflecting different fuels, equivalence ratios, reaction progress, and combustion modes (deflagration and detonation), which influence gas composition and temperature. The sensor was evaluated for accuracy and precision in both a high-enthalpy shock-tube facility in hydrocarbon–air ignition experiments and behind ethylene–oxygen detonation waves in a detonation-impulse tube facility at temperatures from 1500 to 3000 K and pressures from 0.5 to 10 bar. Pressure measurements were compared to measurements by piezoelectric pressure transducers and to theoretical estimates from normal-shock and Chapman-Jouguet simulations. The high-speed path-integrated optical pressure measurement offers an alternative to traditional electromechanical transducers that are constrained to values at wall boundaries and have proven unreliable in some harsh reacting flows.
Assessing phosphorus availability in paddy soils: the importance of integrating soil tests and plant responses
Authors: Martinengo Sara , Schiavon Michela , Santoro Veronica , Said-Pullicino Daniel , Romani Marco , Miniotti Eleonora Francesca , Celi Luisella , Martin Maria 
Published: March 2023

AbstractPhosphorus (P) cycling in paddy soil is closely related to iron (Fe) redox wheel; its availability to rice has thus generally been ascribed to Fe minerals reductive dissolution. However, the literature aimed to identify the best method for predicting rice available P does not uniformly point to Fe reductants. Rice plants can indeed solubilize and absorb P through many strategies as a function of P supply, modifying the chemical environment. Therefore, this study aims to estimate P availability in paddy soils coupling the redox mechanisms driving P cycling with concurrent plant responses. Soil available P was estimated in three groups of paddy soils with low, medium, or high P content assessing easily desorbable pools (0.01 M calcium chloride, Olsen, Mehlich-III, anion exchanging resins) and Fe-bound P pools (EDTA, citrate-ascorbate, and oxalate). Rice P uptake and responses to P availability were assessed by a mesocosm cultivation trial. Although P released in porewater positively correlated with dissolved Fe(II), it did not with plant P uptake, and readily desorbable P pools were better availability predictors than Fe-bound pools, mainly because of the asynchrony observed between Fe reduction and plant P demand. Moreover, in low P soils, plants showed higher Fe(II) oxidation, enhanced root growth, and up-regulation of P root transporter encoding genes, plant responses being related with changes in P pools. These results indicate the generally assumed direct link between Fe reduction and rice P nutrition in paddy soils as an oversimplification, with rice P nutrition appearing as the result of a complex trade-off between soil redox dynamics, P content, and plant responses.
Impact of progesterone on the immune system in women: a systematic literature review
Authors: Zwahlen Michelle , Stute Petra 
Published: March 2023

Abstract
Purpose
The immune system is influenced by many factors, including female sex hormones. The extent of this influence, however, is not completely understood so far. This systematic literature review aims at giving an overview of the existing concepts on how endogenous progesterone influences the female immune system along the menstrual cycle.

Methods
The inclusion criteria were healthy female subjects in their reproductive age with a regular menstrual cycle. The exclusion criteria were exogenous progesterone, animal models, nonhealthy study populations and pregnancy. This led to 18 papers covered in this review. The search was performed using the databases EMBASE, Ovid MEDLINE and Epub, and the last search was conducted on September 18, 2020. Our findings were analyzed in four categories: cellular immune defense, humoral immune defense, objective and subjective clinical parameters.

Results
We demonstrated that progesterone acts in an immunosuppressive way, favoring a Th-2-like cytokine profile. Further, we showed that progesterone inhibits mast cell degranulation and relaxes smooth muscle cells. Furthermore, we found supporting evidence for a so-called window of vulnerability after ovulation, where immune functions are lowered and mediated through progesterone.

Conclusion
The clinical relevance of these findings is not completely understood yet. As the sample sizes of included studies were rather small and the content of them was broad, further investigations are needed to define to which extent the described changes actually clinically meaningful, whether they are capable of influencing the female health and how these findings can be used to increase well-being.
The first rib as a method of adult age-at-death estimation in a modern South African sample
Authors: Jooste Nicolene , Steyn Maryna 
Published: March 2023

AbstractAn age-at-death estimation method using the first rib may be particularly advantageous as this rib is relatively easy to identify, not easily damaged postmortem, and associated with less mechanical stresses compared to other age indicators. Previously, mixed results have been achieved using the first rib to estimate age-at-death. This study aimed to develop and test an age-at-death estimation method using the first rib. An identified modern black South African sample of 260 skeletons were used to collect age-related data from the first rib. Multiple linear regression analysis equations were created from this data for male, female, and combined samples. When tested on a hold-out sample, equations generated mean inaccuracies of 7–13 years for point estimates. The 95% confidence intervals contained the true age in 11–33% of individuals depending on the equation used, but wider intervals generated using 95% prediction intervals contained true ages for 100% of individuals. Point estimate inaccuracies are comparable to other age-at-death estimation methods and may be useful if single indicator estimation is unavoidable in the case of missing or damaged bones. However, combined methods that use indicators from many areas of the skeleton are preferable and may reduce interval widths.
Summer weather perception and preferences in Powsin Culture Park (Warsaw, Poland)
Authors: Rozbicka Katarzyna , Rozbicki Tomasz 
Published: March 2023

AbstractGreen areas situated inside the city play a very important role for many aspects. Among other, from the social point of view, they have a positive impact on the life of city habitants: directly improve well-being and health, reduce noise, provide opportunities for activity and recreation, improve the tourist attractiveness of the city, etc. The objective of this study was to assess thermal sensations and preferences of people staying outdoors for recreational purposes in the area of the city park during summer 2019, as well as to identify how bioclimate perceptions are modified by personal factors (physical and physiological). In order to determine the optimum thermal zone for recreation and urban tourism during the summer, the regression model for mean thermal preferences (MTPV) every 1 °C in PET value intervals was calculated, and according to this procedure, the preferable spectrum of thermal conditions for tourism and recreation in Warsaw which is related to the PET value range between 27.3 and 31.7 °C. All age groups indicated the highest frequency of neutral thermal sensation vote, which decreased with feeling more extreme thermal conditions. In the case of classification by the gender, the men more than the women indicated the thermal conditions as neutral, “slightly warm,” and “warm.” Studies have shown that women were more sensitive than men to extreme thermal sensations especially “hot” and men more often than women indicated greater acceptance for comfortable and warmer thermal conditions.
Searching for nothing: placing zero on the temporal continuum
Authors: Pinto Carlos , Salgado Sara 
Published: March 2023

AbstractGeneralization allows responses acquired in one situation to be transferred to similar situations. For temporal stimuli, a discontinuity has been found between zero and non-zero durations: responses in trials with no (or 0-s) stimuli and in trials with very short stimuli differ more than what would be expected by generalization. This discontinuity may happen because 0-s durations do not belong to the same continuum as non-zero durations. Alternatively, the discontinuity may be due to generalization decrement effects: a 0-s stimulus differs from a short stimulus not only in duration, but also in its presence, thus leading to greater differences in performance. Aiming to reduce differences between trials with and without a stimulus, we used two procedures to test whether a potential reduction in generalization decrement would bring performance following zero and non-zero durations closer. In both procedures, there was a reduction in the discontinuity between 0-s and short durations, supporting the hypothesis that 0-s durations are integrated in the temporal subjective continuum.