bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro activity of aztreonam–avibactam against Enterobacterales isolates collected in Latin America, Africa/Middle East, Asia, and Eurasia for the ATLAS Global Surveillance Program in 2019–2021
Authors: Wise Mark G. , Karlowsky James A. , Mohamed Naglaa , Kamat Shweta , Sahm Daniel F. 
Published: August 2023

AbstractThis study aimed to report reference method antimicrobial susceptibility results for 24,937 recent (2019–2021) clinical isolates of Enterobacterales from 27 countries in Latin America, Eurasia, Africa/Middle East, and Asia with a focus on the investigational combination aztreonam–avibactam against metallo-β-lactamase (MBL) isolates. Antimicrobial susceptibility testing was performed by the CLSI broth microdilution methodology. Minimum inhibitory concentrations (MICs) were interpreted using the CLSI (2022) breakpoints for all agents except aztreonam–avibactam (provisional pharmacokinetic/pharmacodynamic susceptible breakpoint, ≤ 8 mg/L) and tigecycline (US-FDA). Molecular testing for β-lactamase genes was performed on isolates with meropenem MICs ≥ 2 mg/L, ceftazidime–avibactam MICs ≥ 16 mg/L, and/or aztreonam–avibactam MICs ≥ 16 mg/L, and 50% of isolates of Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Klebsiella variicola, and Proteus mirabilis testing with ceftazidime and/or aztreonam MICs ≥ 2 mg/L. Aztreonam–avibactam inhibited 99.8% of all Enterobacterales at ≤ 8 mg/L (MIC90, 0.25 mg/L) and maintained activity against phenotypically resistant subsets of multidrug-resistant (MDR) (99.5% susceptible), extensively drug-resistant (XDR) (98.7%), and carbapenem-resistant Enterobacterales (CRE) (99.1%) isolates. At ≤ 8 mg/L, aztreonam–avibactam inhibited 100%, 99.6%, 99.6%, and 98.8% of KPC-, OXA-48-like-, ESBL-, and MBL-carrying isolates, respectively. MBL-positive isolates were most prevalent in India (20.5%), Guatemala (13.8%), and Jordan (13.2%). No differences in the activity of aztreonam–avibactam were observed across the global regions evaluated. At a concentration of ≤ 8 mg/L, aztreonam–avibactam inhibited almost all Enterobacterales collected from developing countries, including MBL-producing isolates. The widespread dissemination of MBLs among Enterobacterales highlights the unmet need for new agents such as aztreonam–avibactam for the treatment of CRE infections.
A study on the predictive strength of fractal dimension of white and grey matter on MRI images in Alzheimer’s disease
Authors: Di Marco Niccolò , di Palma Azzurra , Frosini Andrea ,   for the Alzheimer’s Disease Neuroimaging Initiative*
Published: August 2023

AbstractMany recent studies have shown that Fractal Dimension (FD), a ratio for figuring out the complexity of a system given its measurements, can be used as an useful index to provide information about certain brain disease. Our research focuses on the Alzheimer’s disease changes in white and grey brain matters detected through the FD indexes of their contours. Data used in this study were obtained from the Alzheimer’s Disease (AD) Neuroimaging Initiative database (Normal Condition, N = 57, and Alzheimer’s Disease, N = 60). After standard preprocessing pipeline, the white and grey matter 3D FD indexes are computed for the two groups. A statistical analysis shows that only grey matter 3D FD indexes are able to differentiate healthy and AD subjects. Although white matter 3D FD indexes do not, it is remarkable that their presence enhance the separation capability of previous ones. In order to valuate the classification capability of these indexes on healthy and AD subjects, we define several Neural Networks models. The performances of these models vary according to the statistical analysis and reach their best performances when each 3D FD input index is changed into a sequence of 2D FD indexes of (a subset of) the horizontal slices of the white and grey matter volumes.
A flexible and lightweight deep learning weather forecasting model
Authors: Zenkner Gabriel , Navarro-Martinez Salvador 
Published: August 2023

AbstractNumerical weather prediction is an established weather forecasting technique in which equations describing wind, temperature, pressure and humidity are solved using the current atmospheric state as input. This study examines deep learning to forecast weather given historical data from two London-based locations. Two distinct Bi-LSTM recurrent neural network models were developed in the TensorFlow deep learning framework and trained to make predictions in the next 24 and 72 h, given the past 120 h. The first trained neural network predicted temperature at Kew Gardens with a forecast accuracy of $$\pm$$
±
2 $${}^{\circ }$$

∘

C in 73% of instances in a whole unseen year, and a root mean squared errors of 1.45 $${}^{\circ }$$

∘

C. The second network predicted 72-h air temperature and relative humidity at Heathrow with root mean squared errors 2.26 $${}^{\circ }$$

∘

C and 14% respectively and 80% of the temperature predictions were within $$\pm$$
±
3 $${}^{\circ }$$

∘

C while 80% of relative humidity predictions were within $$\pm$$
±
20%. Both networks were trained with five years of historical data, with cloud training times of over a minute (24-h network) and three minutes (72-h).
The Sense of Someone Appearing There: A Philosophical Investigation into Other Minds, Deceased People, and Animated Persona
Authors: Morioka Masahiro 
Published: August 2023

AbstractWe sometimes feel the presence of a person-like something on a non-biological object, such as a memento from a deceased family member or a well-engineered, human-shaped robot. This feeling—the sense of someone appearing there—has not been extensively investigated by philosophers. In this paper, I employ examples from previous studies, my own experiences, and thought experiments to conduct a philosophical analysis of the mechanism of the emergence of this person-like something by using the concept of an animated persona. This animation process works not only in cases of deceased people and non-biological objects but also in cases of a living, conscious human being. This suggests that the appearance of the other mind on a human body is not necessarily a reflection of that human’s inner self-consciousness but can be considered a personhood that appears, animated by various surrounding factors. I also propose the concept of “the supremacy of surface-ness over behind-ness”. Finally, I categorize the appearance of an animated persona on a human body or an object into eight patterns and compare their characteristics.
Exact Solutions and Conservation Laws of A (2+1)-dimensional Combined Potential Kadomtsev-Petviashvili-B-type Kadomtsev-Petviashvili Equation
Authors: Sebogodi M. C. , Muatjetjeja B. , Adem A. R. 
Published: August 2023

AbstractThis article investigates a sixth order integrable nonlinear partial differential equation model that fulfills the Hirota N-soliton. Space and time-dependent shift, rotation and space-dependent shift, time and space translations, and time and space dilations Lie point symmetries are presented methodically. Under a specific point symmetries, the Lie point symmetries lead to group invariant solutions. The significance of conservation laws of the underlying equation are shown. The results are quite accurate in recreating complex waves and the dynamics of their interactions.
The meaning of difficulties in career narratives: the case of sports graduates
Authors: Jama Kaisa-Mari , Tynjälä Päivi , Aarto-Pesonen Leena , Malinen Anita , Hämäläinen Raija 
Published: August 2023

AbstractAs the careers of today are no longer typically stable and predictable, people should expect to encounter many challenges during their working life. The present study aimed to explore the meaning of difficulties in modern career-themed life narratives. A total of 54 Finnish sports graduates’ narratives were analysed using reflexive thematic analysis to identify the meanings attributed to difficulties. Findings revealed that difficulties both shaped the plot and initiated multiple types of reflections in the narratives. The paper suggests that difficulties should be considered as a meaningful part of career narratives and discusses the application of the findings in career counselling.
Infertility clinics and acupuncture: a qualitative web-based study
Authors: Magee Bethany , Smith Kevin Richard 
Published: August 2023

AbstractThe increasing demand for fertility treatments has led to the rise of private clinics offering complementary and alternative medicine (CAM) treatments. The most frequently offered CAM infertility treatment is acupuncture. However, there is no good evidence to support the effectiveness of acupuncture in treating infertility. This study evaluates the scope of information provided by CAM fertility clinics in the UK. A content analysis was conducted on 200 websites of CAM fertility clinics in the UK that offer acupuncture as a treatment for infertility. Of the 48 clinics that met the eligibility criteria, the majority of the websites did not provide sufficient information on the efficacy, risks and success rates of acupuncture for infertility. This has the potential to infringe on patient autonomy, provide false hope and reduce the chances of pregnancy ever being achieved as fertility declines during the time course of ineffective acupuncture treatment.
A large-scale television advertising dataset for detailed impression analysis
Authors: Tao Li , Nakamura Shunsuke , Wang Xueting , Kawahara Tatsuya , Tamura Gen , Yamasaki Toshihiko 
Published: August 2023

AbstractCreating impressive video content such as movies and advertisements is a very important yet challenging task in business that requires both a sense of creativity and a lot of experience. Even professionals cannot necessarily invoke the impressions and emotions that they have aimed at. Many video advertisements are created and then disappear without giving a large impact on viewers. This paper presents a large-scale dataset of television (TV) advertisements that consists of 14,490 videos. The impressions of each video such as the recognition rate and interestingness rate are from the results of questionnaires answered by 620 participants. We also present a baseline for predicting the impression effects of TV advertisements by using visual and audio information, metadata such as broadcasting pattern, business category, the popularity of the casts, and text information including texts appearing on videos and narrations in audios. We predict four impressions of the viewers: 1) how much participants remember the video afterward, 2) how much they feel like buying the product/service, 3) how much they become interested in the product/service, and 4) how much they like the content of the advertisement itself. By combining images, audio, metadata, cast data, and text data, our baseline method is able to predict such impressions with a correlation of 0.69-0.82, much better than using a single-modal feature such as visual data or audio data only. This paper also gives some possible applications such as estimating the importance scores of each key frame, which gives us informative insights about how to make the advertisement content more impressive.
How sure are you? — the properties of self-reported conviction in the elicitation of health preferences with discrete choice experiments
Authors: Jakubczyk Michał , Lewandowski Michał 
Published: August 2023

AbstractDiscrete choice experiments (DCE) are often used to elicit preferences, for instance, in health preference research. However, DCEs only provide binary responses, whilst real-life choices are made with varying degrees of conviction. We aimed to verify whether eliciting self-reported convictions on a 0–100 scale adds meaningful information to the binary choice. Eighty three respondents stated their preferences for health states using DCE and the time trade-off method (TTO). In TTO, utility ranges were also elicited to account for preference imprecision. We verified the properties of the conviction across three areas: (1) response to various choice task modifications (e.g. dominance, increase in complexity, distance from the status quo) and association with rationality violations (e.g. intransitivity); (2) association with test–retest results; (3) relation to the utility difference and imprecision estimated in TTO. Regarding (1), conviction increased in choice tasks with lower complexity, larger relative attractiveness, and lower distance to the status quo. Regarding (2), choices made with above-median conviction were sustained in 90% of the cases, compared to 68% for below-median conviction. Regarding (3), the conviction increases with utility difference and it decreases with utility imprecision; overconfidence seems to prevail: non-zero conviction is reported even for identical utilities. Self-reported conviction in DCE is associated in an intuitive way with the observed choices. It may, therefore, be useful in explaining or predicting behaviour or bridging the gap between the results of various elicitation tasks.
Role of penile rehabilitation through daily intake of 5 mg tadalafil on erectile dysfunction after different presentations of penile fracture: a prospective case–control study
Authors: GamalEl Din Sameh Fayek , Nabil Nashaat , Ragab Mohamed Wael , Saad Hany , Labib Mariam , Abo Sief Ahmed 
Published: August 2023

Abstract
Purpose
We aimed in the current study to identify the predictive factors of ED occurrence in healthy individuals following penile fracture surgical repair as well as the effect of penile rehabilitation in the form of daily tadalafil 5 mg intake for 1 month for patients who suffered from ED after penile fracture incident.

Method
The current study was a prospective case–control study. Twenty-five patients were enrolled into the study starting from January (2022) to February (2023). Furthermore, time of presentation was determined, and length of tear intra-operative was measured, and then, a follow-up 1 week postoperatively in the outpatient clinic was conducted. All patients were instructed to start intercourse at least 2 weeks after the first visit provided that the wound epithelialized. Potent patients returned back home. A rehabilitation course of daily tadalafil 5 mg for 1 month was prescribed for patients who started complaining of ED that was confirmed by evaluation with the Arabic validated version of the international index of erectile function (ArIIEF-5). The rehabilitation therapy was terminated by resumption of normal erectile function. Thus, re-evaluation with the ArIIEF-5 was determined according to their response to therapy. Also, the patients were evaluated by hospital anxiety and depression scale (HADS) before and after penile fracture repair.

Results
The current study had demonstrated that a 1% increase in age determines an increase in odds ratio for post-penile fracture ED with 73.6% and 1 cm increase in the length of tear determines an increase in odds ratio for post-penile fracture ED with 20.04 times.

Conclusion
The current study enhances the proper counseling of these patients prior to repairing the defect about the probability of ED occurrence as well as initiating early penile rehabilitation to help these patients resuming their normal sexual activity as soon as possible.
Which symptom to address in psychological treatment for cancer survivors when fear of cancer recurrence, depressive symptoms, and cancer-related fatigue co-occur? Exploring the level of agreement between three systematic approaches to select the focus of treatment
Authors: Harnas Susan J. , Booij Sanne H. , Csorba Irene , Nieuwkerk Pythia T. , Knoop Hans , Braamse Annemarie M. J. 
Published: August 2023

Abstract
Purpose
To investigate the extent to which three systematic approaches for prioritizing symptoms lead to similar treatment advices in cancer survivors with co-occurring fear of cancer recurrence, depressive symptoms, and/or cancer-related fatigue.

Methods
Psychological treatment advices were was based on three approaches: patient preference, symptom severity, and temporal precedence of symptoms based on ecological momentary assessments. The level of agreement was calculated according to the Kappa statistic.

Results
Overall, we found limited agreement between the three approaches. Pairwise comparison showed moderate agreement between patient preference and symptom severity. Most patients preferred treatment for fatigue. Treatment for fear of cancer recurrence was mostly indicated when based on symptom severity. Agreement between temporal precedence and the other approaches was slight. A clear treatment advice based on temporal precedence was possible in 57% of cases. In cases where it was possible, all symptoms were about equally likely to be indicated.

Conclusions
The three approaches lead to different treatment advices. Future research should determine how the approaches are related to treatment outcome. We propose to discuss the results of each approach in a shared decision-making process to make a well-informed and personalized decision with regard to which symptom to target in psychological treatment.

Implications for Cancer Survivors
This study contributes to the development of systematic approaches for selecting the focus of psychological treatment in cancer survivors with co-occurring symptoms by providing and comparing three different systematic approaches for prioritizing symptoms.
Promoting the implementation process of Power Food (‘Krachtvoer’), an educational program on healthy nutrition for prevocational secondary schools
Authors: Driessen-Willems Marion , Kremers Stef , Bartelink Nina , Bessems Kathelijne , Kintzen Conny , van Assema Patricia 
Published: August 2023

AbstractActively promoting the implementation process of health promotion interventions, ensuring their sufficient and appropriate use in practice, requires a planned approach. Many types of implementation strategies can be used for this purpose, selected on the basis of identified determinants of the implementation process in the specific implementation context. Several phases can be distinguished in the implementation process, namely adoption, actual use, sustainability, scaling up, and de-implementation of the intervention. This article describes which implementation strategies have been and are currently used to promote the implementation process of the educational program Power Food (Krachtvoer), an intervention on healthy nutrition for students in Dutch prevocational secondary schools. It also presents visitor data from the Krachtvoer.nu website during the 2019–2020, 2020–2021 and 2021–2022 school years. A reflection on the approach emphasizes the importance of the leading role of the cross-domain project team, the co-creation with users, and the intersectoral cooperation with the national partner network. A national (funding) policy in the Netherlands to support the sustainability of proven effective and well-implementable health promotion interventions is sorely missed.
The DoDo experience: an alternative antiretroviral 2-drug regimen of doravirine and dolutegravir
Authors: Sammet Stefanie , Touzeau-Römer Veronique , Wolf Eva , Schenk-Westkamp Pia , Romano Birgit , Gersbacher Elke , Kastenbauer Ulrich , Boesecke Christoph , Rockstroh Jürgen , Scholten Stefan , Schneeweiss Stephan , Roider Julia , Seybold Ulrich 
Published: August 2023

Abstract
Background
Currently available antiretroviral 2-drug regimen (2DR) fixed dose combinations may not be suitable for specific situations including the presence of resistance associated mutations (RAM) or drug − drug interactions (DDI). The data on the use of the non-nucleoside reverse transcriptase inhibitor doravirine (DOR) and the integrase inhibitor dolutegravir (DTG) as an alternative 2DR remain scarce.

Methods
People living with HIV with DOR + DTG as a 2DR are being followed in a prospective observational study.

Results
This analysis describes 85 participants with a median age of 57 years. Median CD4-nadir was 173/µl and a majority (66%) had a history of HIV-associated or AIDS-defining conditions. Antiretroviral history was mostly extensive, and documentation of RAM was frequent. The main reasons for choosing DOR + DTG were DDI (29%), tolerability (25%), and cardiovascular risk reduction (21%). Plasma viral load at switch was < 50 copies/ml in all but 3 instances, median CD4 count was 600/µl. DOR + DTG was later changed to another regimen in 10 participants after a median of 265 days, the other 75 participants have remained on DOR + DTG for a median of 947 days.

Conclusion
DOR + DTG as a 2DR proved to be a durable treatment option even in extensively pretreated individuals.
A Review of the Reactivity of Phosphatase Controlled by Clays and Clay Minerals: Implications for Understanding Phosphorus Mineralization in Soils
Authors: Chen Ai , Arai Yuji 
Published: August 2023

Abstract
Mineralizable macronutrients (e.g. C, N, P, and S) are sorbed readily (i.e. adsorption and precipitation) in clays and clay minerals. Phosphorus (P) is one of the limiting macronutrients in soils because both phosphate and organic P undergo chemisorption in soil minerals. Furthermore, phosphatases that mineralize the organic P species tend to partition into soil minerals, suppressing the interactions between organic P and phosphatase. Adsorbed phosphatase on the mineral surfaces can regulate the enzyme activity and influence the biochemical properties of the enzyme (e.g. kinetics, conformation, and stability), affecting the P cycle in the terrestrial environment. Phosphatase–mineral interactions are widely reported to decrease the enzyme activity while enhancing the enzyme stability (e.g. thermal and proteolysis stability). Contradictory findings have also been reported. Specific enzymes, mineral characteristics, and reaction conditions are probably responsible for various reactivity (e.g. mineralization). The purpose of the present review was to summarize current and past investigations of acid and alkaline phosphatase sorption in clays and clay minerals and to examine phosphatase chemical properties (e.g. kinetic activity, thermal and proteolysis stability) and factors (e.g. pH, saturating cations of the mineral, enzyme structure, and mineral surface polarity) influencing the phosphatase-mineral interaction. Lastly, also reviewed is the application of phosphatase–mineral interactions with some expansion to other enzymes as an indication of potential future application for phosphatase and future research needs.
Le temps d’un rituel
Authors: Yaya McKenzie Isabel 
Published: August 2023

RésuméEn équilibre précaire sur de petits destriers, les conquérants espagnols
tentent péniblement de transpercer les troupes du souverain Atahualpa qui
défendent à pied le destin de l’Empire inca. La scène est désordonnée, tantôt
tendue, tantôt enjouée, car la plupart de ses interprètes sont en état d’ébriété
avancée. Renvoyant à l’épisode tragique survenu en 1532, cette séquence est
rejouée depuis la première moitié du xviie siècle au cours
de diverses fêtes votives de la Sierra centrale péruvienne. Aujourd’hui, si les
modalités de cette reconstitution peuvent varier d’un endroit à l’autre, elles
sont toujours financées par des laïcs bénévoles ; s’y mêlent messes,
processions, beuveries, banquets, danses collectives, jeux de combat,
divertissements musicaux et, parfois, un spectacle taurin. Ces pratiques
festives s’inscrivent en cela dans une histoire connectée, celle de la
circulation et des reconfigurations des représentations de Maures et chrétiens
dans le monde ibérique. Cet article propose de saisir les dynamiques
institutionnelles, à la croisée du politique et du religieux, qui ont participé
au succès et à la stabilité de cette performance dans les Andes. Il interroge
également la texture de cette longue durée et son articulation avec d’autres
temporalités. À partir d’enquêtes ethnographiques effectuées à Chiquián
(Áncash), l’étude s’attarde en dernier lieu sur les temporalités du rituel :
quels passés, quels présents et quels horizons d’attente s’emboîtent dans les
cadres d’interaction de cette représentation ?