bluuebunny/crossref_metadata_2025_split huggingface dataset:
The MOCAST+ Study on a Quantum Gradiometry Satellite Mission with Atomic Clocks
Authors: Migliaccio Federica , Reguzzoni Mirko , Rosi Gabriele , Braitenberg Carla , Tino Guglielmo Maria , Sorrentino Fiodor , Mottini Sergio , Rossi Lorenzo , Koç Öykü , Batsukh Khulan , Pivetta Tommaso , Pastorutti Alberto , Zoffoli Simona 
Published: February 2023

AbstractIn the past twenty years, satellite gravimetry missions have successfully provided data for the determination of the Earth static gravity field (GOCE) and its temporal variations (GRACE and GRACE-FO). In particular, the possibility to study the evolution in time of Earth masses allows us to monitor global parameters underlying climate changes, water resources, flooding, melting of ice masses and the corresponding global sea level rise, all of which are of paramount importance, providing basic data on, e.g. geodynamics, earthquakes, hydrology or ice sheets changes. Recently, a large interest has developed in novel technologies and quantum sensing, which promise higher sensitivity, drift-free measurements, and higher absolute accuracy for both terrestrial surveys and space missions, giving direct access to more precise long-term measurements. Looking at a time frame beyond the present decade, in the MOCAST+ study (MOnitoring mass variations by Cold Atom Sensors and Time measures) a satellite mission based on an “enhanced” quantum payload is proposed, with cold atom interferometers acting as gravity gradiometers, and atomic clocks for optical frequency measurements, providing observations of differences of the gravitational potential. The main outcomes are the definition of the accuracy level to be expected from this payload and the accuracy level needed to detect and monitor phenomena identified in the Scientific Challenges of the ESA Living Planet Program, in particular Cryosphere, Ocean and Solid Earth. In this paper, the proposed payload, mission profile and preliminary platform design are presented, with end-to-end simulation results and assessment of the impact on geophysical applications.
The Autoimmune Manifestations in Patients with Genetic Defects in the B Cell Development and Differentiation Stages
Authors: Azizi Gholamreza , Hesari Mina Fattah , Sharifinejad Niusha , Fayyaz Farimah , Chavoshzadeh Zahra , Mahdaviani Seyed Alireza , Alan Mahnaz Seifi , Jamee Mahnaz , Tavakol Marzieh , Sadri Homa , Shahrestanaki Ehsan , Nabavi Mohammad , Ebrahimi Sareh Sadat , Shirkani Afshin , Vosughi Motlagh Ahmad , Delavari Samaneh , Rasouli Seyed Erfan , Esmaeili Marzie , Salami Fereshte , Yazdani Reza , Rezaei Nima , Abolhassani Hassan 
Published: February 2023

Abstract
Purpose
Primary B cell defects manifesting as predominantly antibody deficiencies result from variable inborn errors of the B cell lineage and their development, including impairments in early bone marrow development, class switch recombination (CSR), or terminal B cell differentiation. In this study, we aimed to investigate autoimmunity in monogenic patients with B cell development and differentiation defects.

Methods
Patients with known genetic defects in the B cell development and differentiation were recruited from the Iranian inborn errors of immunity registry.

Results
A total of 393 patients with a known genetic defect in the B cell development and differentiation (257 males; 65.4%) with a median age of 12 (6–20) years were enrolled in this study. After categorizing patients, 109 patients had intrinsic B cell defects. More than half of the patients had defects in one of the ATM (85 patients), BTK (76 patients), LRBA (34 patients), and DOCK8 (33 patients) genes. Fifteen patients (3.8%) showed autoimmune complications as their first manifestation. During the course of the disease, autoimmunity was reported in 81 (20.6%) patients at a median age of 4 (2–7) years, among which 65 patients had mixed intrinsic and extrinsic and 16 had intrinsic B cell defects. The comparison between patients with the mentioned four main gene defects showed that the patient group with LRBA defect had a significantly higher frequency of autoimmunity compared to those with other gene defects. Based on the B cell defect stage, 13% of patients with early B cell defect, 17% of patients with CSR defect, and 40% of patients who had terminal B cell defect presented at least one type of autoimmunity.

Conclusion
Our results demonstrated that gene mutations involved in human B cell terminal stage development mainly LRBA gene defect have the highest association with autoimmunity.
Desert Retributivism: A Deweyan Critique
Authors: Poama Andrei 
Published: February 2023

AbstractIn this article, I argue that Michael Moore’s (1997), and other similar formulations of desert retributivism – viz., the theory that holds punishment to be justified because of the deserved suffering it imposes on guilty offenders – are epistemically problematic. The argument draws on John Dewey’s inchoate critique of retribution, and on Dewey’s more general contention that the justification of ethical judgments and principles proceeds ex post – viz., that it depends on the experiences elicited by acting on those judgments and principles. Based on Dewey’s ex post take on justification, I more specifically argue that, given its commitment to moral naturalism and to coherentism, Moore’s version of desert retributivism is epistemically unwarranted. This is because we have evidentially grounded reasons to think that many of the retributive judgments that underlie the principle of retributive justice are not clearly supported ex post in the relevant, desert retributivist sense.
“I Just Want to Be Me, Authentically”: Identity Shifting Among Racially and Ethnically Diverse Young Adults
Authors: Loyd Aerika Brittian , Westberg Dulce Wilkinson , Williams LeNisha , Humphries Marisha , Meca Alan , Rodil Julie C. 
Published: February 2023

AbstractIdentity shifting represents a common but complex social, behavioral, and cognitive phenomenon. However, some forms of identity shifting originate in response to structural, institutional, and interpersonal marginalization enacted on lower status groups, such as people of color in the United States. The current study investigated ways young adults from diverse ethnic/racial groups discussed shifting to fit in with White Americans (a dominant group) in the United States and their own ethnic/racial group (a minoritized group) and elucidated self-reported motivations for shifting. Participants consisted of 764 young adults (ages = 18–23) recruited from two large public universities in the Southeast and Southwest regions of the United States. The majority of participants identified as Black/African American (41%), Asian/Asian American (27%), or Hispanic/Latinx (22%). Analysis of participants’ qualitative responses identified six types of shifts and two motivations for shifting. The shifts included:behavioral, linguistic, cognitive, physical, food, and affect. Motivations for shifting focused on avoiding risks and obtaining rewards. The discussion offers interpretation of the results and recommendations for future research on identity shifting.
Numerical methods for control-based continuation of relaxation oscillations
Authors: Blyth Mark , Tsaneva-Atanasova Krasimira , Marucci Lucia , Renson Ludovic 
Published: February 2023

AbstractControl-based continuation (CBC) is an experimental method that can reveal stable and unstable dynamics of physical systems. It extends the path-following principles of numerical continuation to experiments and provides systematic dynamical analyses without the need for mathematical modelling. CBC has seen considerable success in studying the bifurcation structure of mechanical systems. Nevertheless, the method is not practical for studying relaxation oscillations. Large numbers of Fourier modes are required to describe them, and the length of the experiment significantly increases when many Fourier modes are used, as the system must be run to convergence many times. Furthermore, relaxation oscillations often arise in autonomous systems, for which an appropriate phase constraint is required. To overcome these challenges, we introduce an adaptive B-spline discretisation that can produce a parsimonious description of responses that would otherwise require many Fourier modes. We couple this to a novel phase constraint that phase-locks control target and solution phase. Results are demonstrated on simulations of a slow-fast synthetic gene network and an Oregonator model. Our methods extend CBC to a much broader range of systems than have been studied so far, opening up a range of novel experimental opportunities on slow-fast systems.
Hungarian PROMIS-29+2: psychometric properties and population reference values
Authors: Jenei Balázs , Bató Alex , Mitev Ariel Z. , Brodszky Valentin , Rencz Fanni 
Published: February 2023

Abstract
Objectives
This study aims to assess psychometric properties of the Hungarian PROMIS-29+2 profile measure and provide general population reference values for Hungary.

Methods
An adult general population sample (n = 1700) completed PROMIS-29+2 v2.1 in an online survey. The following psychometric properties were assessed: floor and ceiling effect, convergent validity with SF-36v1 domains, internal consistency (McDonald’s omega), unidimensionality, local independence, monotonicity, graded response model (GRM) fit and differential item functioning (DIF). Age- and gender-specific reference values were established using the US item calibrations.

Results
Depending on scale orientation, high floor or ceiling effects were observed for all domains (25.2–60.7%) except for sleep disturbance. McDonald’s omega for domains ranged from 0.87–0.97. Unidimensionality, local independence and monotonicity were supported and the GRM adequately fitted for all but one domains. The sleep disturbance domain demonstrated item misfit, response level disordering and low discrimination ability, particularly for item Sleep116 (‘refreshing sleep’). Strong correlations were observed between PROMIS-29+2 and corresponding SF-36 domains (rs=│0.60│ to │0.78│). No DIF was detected for most sociodemographic characteristics. Problems with physical function, pain interference and social roles tended to increase, whereas problems with anxiety, depression, fatigue and cognitive function declined with age (p < 0.01). In all domains except for cognitive function, more health problems occurred in females than in males (p < 0.001).

Conclusion
The Hungarian PROMIS-29+2 shows satisfactory psychometric properties; however, the sleep disturbance domain substantially underperforms that requires further attention. Population reference values were generated that facilitate the interpretation of health outcomes in various patient populations.
Mapping the national HPC ecosystem and training needs: The Greek paradigm
Authors: Karozis Stelios , Ziouvelou Xenia , Karkaletsis Vangelis 
Published: February 2023

AbstractHPC is a key tool for processing and analyzing the constantly growing volume of data, from 64.2 zettabytes in 2020 to an expected 180 zettabytes in 2025 (1 zettabyte is equal to 1 trillion gigabytes). As such, HPC has a large number of application areas that range from climate change, monitoring and mitigating planning to the production of safer and greener vehicles and treating COVID-19 pandemic to the advancement of knowledge in almost every scientific field and industrial domain. The current work presents an HPC Training Mapping Framework and the relevant findings and processed data of an online Training Needs Analysis (TNA) survey. The latter was used to map the training demands and gaps of existing skills and future ones. The participants consist of academia and industry and the data were utilized to find the profile of HPC user alongside the best training practices that are in need. It is found that in Greece during the year 2021, the stakeholder segment with the highest number of respondents was from academia and research with a total of 74%. The vast majority appear to have basic information accounting for 37% of the respondents. In terms of familiarity, users with intermediate familiarity with HPC represented 21% of respondents, followed by non-familiar users that accounted in total for 16.1. Advanced and highly advanced user segments account only for 8.6% and 7.4% accordingly. Overall, it is found that a: (1) fast-pace, (2) entry level, (3) applied HPC training but (4) not focused only on HPC, that will (5) provide some kind of certification, by the Greek HPC ecosystem.
Numerical and experimental study of aerosol dispersion in the Do728 aircraft cabin
Authors: Schmeling D. , Shishkin A. , Schiepel D. , Wagner C. 
Published: February 2023

AbstractThe dispersion of aerosols originating from one source, the ‘index’ passenger, within the cabin of the aircraft Do728 is studied experimentally using an aerosol-exhaling thermal manikin and in Reynolds-averaged Navier–Stokes simulations (RANS). The overall aim of the present study is the experimental determination of the aerosol spreading for the state-of-the-art mixing ventilation (MV) and to evaluate the potential of alternative ventilation concepts for controlling the aerosol spreading in RANS. For MV, the experiments showed that the ratio of inhaled to exhaled aerosol particles drops below 0.06% (volume ratio) for distances larger than two seat rows from the source. However, within a single row, the observed ratio is higher. Further, the dispersion is much weaker for a standing than for a seated index passenger. High air exchange rates and a well-guided flow prevent a dispersion of the aerosols in high concentrations over larger distances. Additionally, the positive effect of a mask and an increased air flow rate, and especially their combination are shown. In the complementary conducted RANS, the advantages of floor-based cabin displacement ventilation (CDV) which is alternative ventilation concept to MV, regarding spreading lengths and the dwell time of the aerosols in the cabin were determined. The obtained results also underline the importance of the flow field for the aerosol dispersion. Further, additional unsteady RANS (URANS) simulations of the short-term process of the initial aerosol cloud formation highlighted that the momentum decay of the breathing and the evaporation processes take place within a few seconds only.
Blood and cerebrospinal fluid biomarker changes in patients with HIV-associated neurocognitive impairment treated with lithium: analysis from a randomised placebo-controlled trial
Authors: Thela Lindokuhle , Decloedt Eric , Zetterberg Henrik , Gisslén Magnus , Lesosky Maia , Gleich Melanie , Koutsilieri Eleni , Scheller Carsten , Hye Abdul , Joska John 
Published: February 2023

AbstractHIV-associated neurocognitive disorders (HAND) persist in the era of antiretroviral therapy (ART). Thus, ART does not completely halt or reverse the pathological processes behind HAND. Adjuvant mitigating treatments are, therefore, prudent. Lithium treatment is known to promote neuronal brain–derived neurotrophic factors (BDNF). Lithium is also an inhibitor of glycogen synthase kinase-3 beta (GSK-3-β). We analyzed biomarkers obtained from participants in a randomized placebo-controlled trial of lithium in ART-treated individuals with moderate or severe HAND. We assayed markers at baseline and 24 weeks across several pathways hypothesized to be affected by HIV, inflammation, or degeneration. Investigated biomarkers included dopamine, BDNF, neurofilament light chain, and CD8 + lymphocyte activation (CD38 + HLADR +). Alzheimer’s Disease (AD) biomarkers included soluble amyloid precursor protein alpha and beta (sAPPα/β), Aβ38, 40, 42, and ten other biomarkers validated as predictors of mild cognitive impairment and progression in previous studies. These include apolipoprotein C3, pre-albumin, α1-acid glycoprotein, α1-antitrypsin, PEDF, CC4, ICAM-1, RANTES, clusterin, and cystatin c. We recruited 61 participants (placebo = 31; lithium = 30). The age baseline mean was 40 (± 8.35) years and the median CD4 + T-cell count was 498 (IQR: 389–651) cells/μL. Biomarker concentrations between groups did not differ at baseline. However, both groups’ blood dopamine levels decreased significantly after 24 weeks (adj. p < 002). No other marker was significantly different between groups, and we concluded that lithium did not confer neuroprotection following 24 weeks of treatment. However, the study was limited in duration and sample size.
International comparative analysis to understand the capacity for arthroscopy training and practice in developing countries
Authors: Goldhaber Nicole H. , Qudsi Rameez A. , Polinsky Samuel , Stupay Kristen L. , Katz Jeffrey N. , Stetson William B. , Dyer George S. M. , Investigators Co-Principal 
Published: February 2023

Abstract
Purpose
Arthroscopy is an efficacious and popular treatment modality in developed nations for a variety of musculoskeletal conditions. However, arthroscopy requires specialized training, complex infrastructure, and expensive equipment, occasionally causing barriers to use in developing countries. Consequently, the utilization of resources to perform and teach arthroscopy in low- and middle-income countries (LMICs) is controversial. Through this investigation, we assessed the current capacity and barriers to arthroscopy use and training in these settings.

Methods
Focused interviews were conducted with surgeons from Haiti (low-income) and Romania (middle-income) regarding their experience with arthroscopy. Based on responses, a multiple-choice survey was developed and administered to orthopaedic trainees and practicing orthopaedic surgeons during national orthopaedics conferences in each country.

Results
Fifty-eight orthopaedists in Haiti, and 29 in Romania completed the survey. Most (91% from Haiti; 79% from Romania) reported that learning arthroscopy is essential or important for orthopaedic training in their country. Yet only 17% from Haiti compared to 69% from Romania indicated their primary hospital has the equipment necessary for arthroscopy. In Haiti, equipment was the main barrier to use of arthroscopy, followed by training, while in Romania, the main barrier was training, followed by equipment. Simulations and telemedicine were ranked as top choices of effective methods for learning arthroscopy.

Conclusions
Regardless of their country’s resource limitations, most participants place high value on the practice of arthroscopy and arthroscopic training. The results from this study highlight a hierarchy of needs in developing nations. Furthermore, local providers report a strong belief in the need for arthroscopic treatment to benefit their patients, and a clear desire for further training and development of these techniques. By identifying similarities and differences by location, we may better tailor global orthopaedic training initiatives and partnerships in LMICs.
An Enhanced Partitioning Approach in SpatialHadoop for Handling Big Spatial Data
Authors: Shehab Abdulaziz , Elashry Ahmed , Aboul-Fotouh Ahmed , Riad Alaa 
Published: February 2023

AbstractSpatialHadoop could handle spatial data operations in a low partitioning execution time compared to the traditional Hadoop. However, developing an efficient and an accurate partitioning algorithm is still a research field opened to many researchers. Confidently, this paper proposes a Minimum Boundary Rectangle-aware Priority R-Tree (MBR-aware PR-Tree) as an enhanced partitioning algorithm applicable at SpatialHadoop. Compared to state-of-art partitioning algorithms, our proposed algorithm outperforms them in terms of query execution time, file size, number of partitions, indexing time, and number of returned objects. The experimental results show superiority of our algorithm which have been confirmed for both spatial range query and k-nearest-neighbour query through evaluating the performance in different scenarios using a real dataset.
Influence of assisted reproductive technology and uterine leiomyoma on pregnancy outcomes in women with adenomyosis
Authors: Wang Yi-Ling , Tian Zhao , Chang Xiao-Hong , Zhu Hong-Lan , Cui Heng 
Published: February 2023

AbstractAimTo assess whether adverse pregnancy outcomes in women with adenomyosis are different according to the method of conception and the concurrent of uterine leiomyoma (UL).MethodsWe performed a retrospective study. Fifty-three singleton pregnancy cases complicated with adenomyosis were included in this study. In the study group, 15 women became pregnant with assisted reproductive technology (ART) and 21 women combined with UL. Pregnancy outcomes were compared between ART and non-ART, UL and non-UL groups.ResultsThe prevalence for such complications as hypertensive disorder complicating pregnancy (HDCP)and postpartum hemorrhage (PPH)were significantly higher in the women conceived by ART (33.3% vs. 5.3%, P ​= ​0.023) and (53.3% vs. 23.7%, P ​= ​0.037),respectively. And women concurrent with UL of which the diameter≥4 ​cm were more likely to have severe PPH (44.4% vs. 0%, P ​= ​0.021).ConclusionART may increase the risk of adverse pregnancy outcomes such as HDCP and PPH in women with adenomyosis and UL of which the diameter≥4 ​cm may further increase the risk of severe PPH.
Beirut Blast: The Experiences of Acute Care Hospitals
Authors: Al-Hajj Samar , Ghamlouche Layal , Nasser AlDeen Khawla , El Sayed Mazen 
Published: February 2023

Abstract
Mass Casualty Incidents recently increased in intensity and frequency at an unprecedented rate globally. On August 4, 2020, a massive blast hit the Port of Beirut severely damaging its healthcare sector. This study aims to provide a comprehensive understanding of the impact of the Beirut blast on acute care hospitals in the Beirut area, with a focus on understanding healthcare professionals’ (HCPs) responses and encountered challenges. A qualitative research design method was adopted to evaluate the experiences of HCPs at acute hospitals located within 5 kilometers of the blast epicenter. 9 hospitals participated in the study. 11 semi-structured interviews were conducted with key informant HCPs using a designed interview guide. HCPs reported severe infrastructural damages in their corresponding hospitals, and 2 were completely non-functional post-blast. Other than physical injuries sustained by HCPs, the blast imposed substantial strains on their mental health, exacerbated by the ongoing socio-economic crises in Lebanon. Moreover, the findings revealed critical challenges which hindered hospitals’ emergency responses at the level of communication, coordination, and human resources, as well as supplies. Participants urged for the need to conduct proper triage, arrange emergency operating centers, and deploy outdoor treatment tents among others, to effectively respond to future disasters. The Beirut blast overwhelmed the Lebanese healthcare system and challenged its level of emergency preparedness. This generated evidence to address the deficiencies and strengthen the existing hospitals’ emergency response plans. Future efforts should include prioritizing hospitals’ emergency preparedness to ensure the provision of care at increased capacity following the impact of a large-scale disaster.