bluuebunny/crossref_metadata_2025_split huggingface dataset:
The catalytic performance of CuFe2O4@CQD nanocomposite as a high-perform heterogeneous nanocatalyst in nitroaniline group reduction
Authors: Naghash-Hamed Samin , Arsalani Nasser , Mousavi Seyed Borhan 
Published: February 2023

AbstractIn this study, we fabricated an economical, non-toxic, and convenient magnetic nanocomposite of CuFe2O4 nanoparticles (NPs)/carbon quantum dots (CQDs) of citric acid via the co-precipitation method. Afterward, obtained magnetic nanocomposite was used as a nanocatalyst to reduce the ortho-nitroaniline (o-NA) and para-nitroaniline (p-NA) using a reducer agent of sodium borohydride (NaBH4). To investigate the functional groups, crystallite, structure, morphology, and nanoparticle size of the prepared nanocomposite, FT-IR, XRD, TEM, BET, and SEM were employed. The catalytic performance of the nanocatalyst was experimentally evaluated based on the ultraviolet–visible absorbance to assess the reduction of o-NA and p-NA. The acquired outcomes illustrated that the prepared heterogeneous catalyst significantly enhanced the reduction of o-NA and p-NA substrates. The analysis of the absorption showed a remarkable decrease for ortho-NA and para-NA at λmax = 415 nm in 27 s and λmax = 380 nm in 8 s, respectively. The constant rate (kapp) of ortho-NA and para-NA at the stated λmax was 8.39 × 10–2 s−1 and 5.48 × 10–1 s−1. The most highlighted result of this work was that the CuFe2O4@CQD nanocomposite fabricated from citric acid performed better than absolute CuFe2O4 NPs, since nanocomposite containing CQDs had a more significant impact than copper ferrite NPs.
Repeatability and reproducibility of cardiac manganese-enhanced magnetic resonance imaging
Authors: Singh T. , Joshi S. , Meah M. N. , Spath N. B. , Papanastasiou G. , Kershaw L. E. , Baker A. H. , Dweck M. R. , Newby D. E. , Semple S. I. 
Published: February 2023

AbstractManganese-enhanced magnetic resonance imaging can provide a surrogate measure of myocardial calcium handling. Its repeatability and reproducibility are currently unknown. Sixty-eight participants: 20 healthy volunteers, 20 with acute myocardial infarction, 18 with hypertrophic and 10 with non-ischemic dilated cardiomyopathy underwent manganese-enhanced magnetic resonance imaging. Ten healthy volunteers were re-scanned at 3 months. Native T1 values and myocardial manganese uptake were assessed for intra and inter-observer repeatability. Scan-rescan reproducibility was assessed in ten healthy volunteers. Intra-observer and inter-observer correlation was excellent in healthy volunteers for mean native T1 mapping [Lin’s correlation coefficient (LCC) 0.97 and 0.97 respectively] and myocardial manganese uptake (LCC: 0.99 and 0.96 respectively). Scan-rescan correlation for native T1 and myocardial manganese uptake was also excellent. Similarly, intra-observer correlations for native T1 and myocardial manganese uptake in patients with acute myocardial infarction (LCC: 0.97 and 0.97 respectively), hypertrophic (LCC: 0.98 and 0.97 respectively) and dilated cardiomyopathy (LCC: 0.99 and 0.95 respectively) were excellent. Limits of agreement were broader in patients with dilated cardiomyopathy. Manganese-enhanced magnetic resonance imaging has high repeatability and reproducibility in healthy myocardium and high repeatability in diseased myocardium. However, further study is needed to establish robustness in pathologies with diffuse myocardial fibrosis.
Development of an array of molecular tools for the identification of khapra beetle (Trogoderma granarium), a destructive beetle of stored food products
Authors: Wu Yunke , Domingue Michael J. , McGraw Alana R. , Vieira Kendra A. , Palmeri Marjorie Z. , Myers Scott W. 
Published: February 2023

AbstractTrogoderma granarium Everts, the khapra beetle, native to the Indian subcontinent, is one of the world’s most destructive pests of stored food products. Early detection of this pest facilitates prompt response towards the invasion and prevents the need for costly eradication efforts. Such detection requires proper identification of T. granarium, which morphologically resembles some more frequently encountered, non-quarantine congeners. All life stages of these species are difficult to distinguish using morphological characters. Additionally, biosurveillance trapping can result in the capture of large numbers of specimens awaiting identification. To address these issues, we aim to develop an array of molecular tools to rapidly and accurately identify T. granarium among non-target species. Our crude, cheap DNA extraction method performed well for Trogoderma spp. and is suitable for downstream analyses including sequencing and real-time PCR (qPCR). We developed a simple quick assay usingrestriction fragment length polymorphism to distinguish between T. granarium and the closely related, congeneric T. variabile Ballion and T. inclusum LeConte. Based on newly generated and published mitochondrial sequence data, we developed a new multiplex TaqMan qPCR assay for T. granarium with improved efficiency and sensitivity over existing qPCR assays. These new tools benefit regulatory agencies and the stored food products industry by providing cost- and time-effective solutions to enhance the identification of T. granarium from related species. They can be added to the existing pest detection toolbox. The selection of which method to use would depend on the intended application.
Accelerated germination of aged recalcitrant seeds by K+-rich bulk oxygen nanobubbles
Authors: Kim Mijung , Shoji Akio , Kobayashi Toshiaki , Shirai Yasuyuki , Sugawa Shigetoshi , Takahashi Masayoshi 
Published: February 2023

AbstractBulk nanobubbles, measuring less than 200 nm in water, have shown their salient properties in promoting growth in various species of plants and orthodox seeds, and as potential drug-delivery carriers in medicine. Studies of recalcitrant seeds have reported markedly increased germination rates with gibberellin treatment; however, neither the mechanism promoting germination nor the implication for food safety is well elucidated. In our study, recalcitrant wasabi (Eutrema japonicum) seeds treated with bulk oxygen nanobubbles (BONB) containing K+, Na+, and Cl− (BONB-KNaCl) showed significantly accelerated germination. As germination progressed, 99% of K+ ions in the BONB-KNaCl medium were absorbed by the seeds, whereas Ca2+ ions were released. These results suggest that the germination mechanism involves the action of K+ channels for migration of K+ ions down their concentration gradient and Ca2+ pumps for the movement of Ca2+ ions, the first potential discovery in germination promotion in recalcitrant seeds using nutrient solutions with BONB-KNaCl.
Correlates of burnout among healthcare workers during the COVID-19 pandemic in South Korea
Authors: Hwang Soyoon , Kwon Ki Tae , Lee So Hee , Kim Shin-Woo , Chang Hyun-Ha , Kim Yoonjung , Bae Sohyun , Cheong Hae Suk , Park Se Yoon , Kim Bongyoung , Lee Shinwon , Park Jiho , Heo Sang Taek , Oh Won Sup , Kim Yeonjae , Park Kyung-Hwa , Kang Chang Kyung , Oh NamHee , Lim Su Jin , Yun Seongcheol , Son Ji Woong , Ryoo Hyun Wook , Chung Un Sun , Lee Ju-Yeon , Park Hye Yoon , Shin Ji-Yeon , Bae Sang-geun , Lee Ji-yeon 
Published: February 2023

AbstractBurnout is a form of negative emotional and physical response to job stress. This study aimed to investigate the prevalence of burnout among healthcare workers responding to the coronavirus disease 2019 (COVID-19) outbreak in Korea and to explore correlates of burnout among healthcare workers. A nationwide questionnaire-based survey was conducted from December 1, 2020, to January 29, 2021 on 1425 healthcare workers who worked in one of the 16 healthcare facilities designated for COVID-19 care, in public health centers, or as paramedics in Korea. Burnout was assessed using 16 Korean-adapted items based on the Oldenburg Burnout Inventory (OLBI). Data were collected using a structured questionnaire and analyzed using the R version 4.1.1 software program. OLBI results indicate clinically exhaustion in 84.5% (1204/1425) and clinically disengagement in 91.1% (1298/1425), and 77.3% (1102/1425) met the score criteria for both the exhaustion and disengagement subscales for burnout. Burnout rate was significantly increased in the group with chronic fatigue symptoms (Fatigue Severity Scale ≥ 3.22) after the outbreak of COVID-19 (OR, 3.94; 95% CI 2.80–5.56), in the female group (OR, 2.05; 95% CI 1.46–2.86), in the group with physical symptoms (Patient Health Questionnaire-15 ≥ 10) after the outbreak of COVID-19 (OR, 2.03; 95% CI 1.14–3.60), in the group with a higher Global Assessment of Recent Stress scale (OR, 1.71; 95% CI 1.46–2.01), in the group with post-traumatic stress symptoms (Primary Care Post-Traumatic Stress Disorder-5 ≥ 2) (OR, 1.47; 95% CI 1.08–2.01), and in the younger age group(OR, 1.45; 95% CI 1.22–1.72). The chronic fatigue symptoms were correlated with cumulative days of care (OR, 1.18; 95% CI 1.02–1.37). The physical symptoms were correlated with average contact hours with COVID-19 patients per day (OR, 1.34; 95% CI 1.17–1.54), and cumulative days of care (OR, 1.21; 95% CI 1.06–1.38). Most Korean healthcare workers suffered from burnout related to excessive workload during the COVID-19 pandemic. During a widespread health crisis like COVID-19, it is necessary to regularly check the burnout status in healthcare workers and reduce their excessive workload by supplementing the workforce and providing appropriate working hours sufficient rest hours.
Re-analysis of publicly available methylomes using signal detection yields new information
Authors: Hafner Alenka , Mackenzie Sally 
Published: February 2023

AbstractCytosine methylation is an epigenetic mark that participates in regulation of gene expression and chromatin stability in plants. Advancements in whole genome sequencing technologies have enabled investigation of methylome dynamics under different conditions. However, the computational methods for analyzing bisulfite sequence data have not been unified. Contention remains in the correlation of differentially methylated positions with the investigated treatment and exclusion of noise, inherent to these stochastic datasets. The prevalent approaches apply Fisher’s exact test, logistic, or beta regression, followed by an arbitrary cut-off for differences in methylation levels. A different strategy, the MethylIT pipeline, utilizes signal detection to determine cut-off based on a fitted generalized gamma probability distribution of methylation divergence. Re-analysis of publicly available BS-seq data from two epigenetic studies in Arabidopsis and applying MethylIT revealed additional, previously unreported results. Methylome repatterning in response to phosphate starvation was confirmed to be tissue-specific and included phosphate assimilation genes in addition to sulfate metabolism genes not implicated in the original study. During seed germination plants undergo major methylome reprogramming and use of MethylIT allowed us to identify stage-specific gene networks. We surmise from these comparative studies that robust methylome experiments must account for data stochasticity to achieve meaningful functional analyses.
Access to information and oncofertility consultation for young women with breast cancer: a population-based study
Authors: Martinet-Kosinski Florian , Lamy Sébastien , Bauvin Eric , Dalenc Florence , Vaysse Charlotte , Grosclaude Pascale 
Published: February 2023

AbstractNon-menopausal women with breast cancer treated with chemotherapy are at intermediate risk of post-treatment amenorrhea and decreased fertility. Although they should receive appropriate information, studies until now show that this is inadequate. We investigated the proportion of women who received information about this risk during the pre-treatment consultation, and those who received an oncofertility consultation to preserve their gametes. We also analysed the medical and non-medical factors influencing the transmission of information to patients and their uptake of oncofertility consultations. We included women aged 18–40 years treated with chemotherapy for breast cancer between 2012 and 2017 in the Midi-Pyrénées region (ca. 3 million inhabitants), France. Studied variables were included in a multilevel model. Among the 575 women, 41% of the women received information and 28% received an oncofertility consultation. These two steps on the care pathway were significantly influenced by the type of care structure, the woman's age, her parity at the time of diagnosis, and the metastatic status of the cancer. Female oncologist gender was significantly associated with higher transmission rate. We found no association between neoadjuvant chemotherapy status, level of deprivation (EDI), triple-negative status, marital status, and first-degree family history of cancer and information transmission or uptake of oncofertility consultation. Our study shows that not enough women are informed and have recourse to an oncofertility consultation. Despite a legal obligation, the health care system does not offer the necessary conditions for access to oncofertility care.
Predicting anti-cancer activity in flavonoids: a graph theoretic approach
Authors: Mukwembi Simon , Nyabadza Farai 
Published: February 2023

AbstractIn drug design, there are two major causes of drug failure in the clinic. First, the drug has to work, and second, the drug should be safe. Identifying compounds that work for certain ailments require enormous experimental time and, in general, is cost intensive. In this paper, we are concerned with melanoma, a special type of cancer that affects the skin. In particular, we seek to provide a mathematical model that can predict the ability of flavonoids, a vast and natural class of compounds that are found in plants, in reversing or alleviating melanoma. The basis for our model is the conception of a new graph parameter called, for lack of better terminology, graph activity, which captures melanoma cancer healing properties of the flavonoids. With a superior coefficient of determination, $$R^2=1$$

R
2

=
1

, the new model faithfully reproduces anti-cancer activities of some known data-sets. We demonstrate that the model can be used to rank the healing abilities of flavonoids which could be a powerful tool in the screening, and identification, of compounds for drug candidates.
Research on the flow experience and social influences of users of short online videos. A case study of DouYin
Authors: Zheng Cheng 
Published: February 2023

AbstractRecently, short online videos have been highly recognized by video market users and have developed rapidly. This study aims to explore why users enjoy watching and sharing short online videos by applying the theory of flow experience. Previous research has extensively examined traditional video arts such as TV and movies and text or image based, while research on short online videos has increased only in recent years. To improve the precision and comprehensiveness of the research, social influence is also used as a variable. This study takes the short video representative platform DouYin as a case study and the Chinese user market as the background. Through questionnaires, 406 users' data about short online video experiences were collected. After statistical analysis, the study finds that flow experience has a significant impact on participative behaviour and sharing behaviour for short online videos. According to further analyses, the flow experience, social norms, perceived critical mass and participative and sharing behaviour constitute three groups of mediating relationships. Finally, the discussion of the research results provides help to broaden the academic scope of the flow experience and video art, improve the short online video platform environment, and upgrade short online video services.
Discounting money and health effects from communicable and noncommunicable diseases in Thailand
Authors: Yadee Jirawit , Permsuwan Unchalee , Guntawongwan Kansinee , Himakalasa Woraluck , Buddhawongsa Piyaluk 
Published: February 2023

AbstractThe purpose of this study was to determine the discount rates for money and health outcomes in the Thai context, including the discount rates for communicable and non-communicable diseases. Moreover, this study aimed to explore the socio-demographic characteristics that influence discounting. The computer-based experimental design was used to obtain time preferences for money and health in a total of 1202 Chiang Mai province population, aged 25–50, individually interviewed by trained interviewers. Money-related questions were carried out in all subjects. For health-related questions, all subjects were randomly assigned in a 1:1 ratio for response to questions about Coronavirus Disease 2019 (COVID-19) (N = 602) and air pollution (N = 600). A choice-based elicitation procedure was performed in the experiment to obtain the indifference values from subjects’ time preferences. The cumulative weighting functions were generated using the indifference values to indicate the degree of discounting. The discount factors were computed from the cumulative weighting functions. The discount rates were estimated using a continuous approximation based on the relationship between the discount factors and the parameters governing the discounting model. The Tobit model was applied to investigate the relationships between discounting and socio-demographic characteristics. Discounting for money was greater than discounting for health. Money and health had annual discount rates of 6.2% and 1.3%, respectively. Furthermore, in the COVID -19 situation, the annual discount rate for health was higher than that in the air pollution situation (2.4% vs. 0.7%). Generation X subjects (aged 42 years and above), children under the age of 15 in the household, and underlying diseases were positively related to discounting, while household income was negatively related to discounting. Health should be discounted at a lower rate than money. Moreover, different discount rates should be considered for different types of diseases.
Part I observational study on a new mechanism for North Pacific Oscillation influencing the tropics
Authors: Zhao Jiuwei , Sung Mi-Kyung , Park Jae-Heung , Luo Jing-Jia , Kug Jong-Seong 
Published: February 2023

AbstractThe North Pacific Oscillation (NPO), a representative midlatitude atmospheric variability, plays an important role in the development of the El Niño-Southern Oscillation (ENSO). To explain this extratropical–tropical linkage, previous studies have focused on the atmospheric boundary layer processes coupled with the mixed-layer ocean. Different from the existing hypothesis, in this study, we propose a new mechanism to link the NPO to ENSO via upper-tropospheric teleconnections. Analyses of the wave activity flux show that wave energy associated with the NPO directly propagates from midlatitude to the tropics, modulating the tropical circulation. During the NPO event, this equatorward energy flux becomes pronounced after the NPO peak phase and persists for more than two weeks. As a result, when a positive NPO grows (here, north anticyclonic–south cyclonic circulation), upper-level easterly wind anomalies are situated along the equatorial Pacific. Accordingly, anomalous lower-level westerly winds simultaneously occur in the equatorial Pacific, contributing to the development of El Niño events. To demonstrate the wave energy propagation via the upper-level troposphere, a stationary wave model experiment was performed with an NPO-like barotropic vorticity forcing. The results show equatorward wave propagation consistent with the observation.
Nucleated red blood cells explain most of the association between DNA methylation and gestational age
Authors: Haftorn Kristine L. , Denault William R. P. , Lee Yunsung , Page Christian M. , Romanowska Julia , Lyle Robert , Næss Øyvind E. , Kristjansson Dana , Magnus Per M. , Håberg Siri E. , Bohlin Jon , Jugessur Astanand 
Published: February 2023

AbstractDetermining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of gestational age (GA) in 953 newborns from the Norwegian MoBa study identified 13,660 CpGs significantly associated with GA (pBonferroni<0.05) after adjustment for cell type composition. When the CellDMC algorithm was applied to explore cell-type specific effects, 2,330 CpGs were significantly associated with GA, mostly in nucleated red blood cells [nRBCs; n = 2,030 (87%)]. Similar patterns were found in another dataset based on a different array and when applying an alternative algorithm to CellDMC called Tensor Composition Analysis (TCA). Our findings point to nRBCs as the main cell type driving the DNAm–GA association, implicating an epigenetic signature of erythropoiesis as a likely mechanism. They also explain the poor correlation observed between epigenetic age clocks for newborns and those for adults.
Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle
Authors: Takhaveev Vakil , Özsezen Serdar , Smith Edward N. , Zylstra Andre , Chaillet Marten L. , Chen Haoqi , Papagiannakis Alexandros , Milias-Argeitis Andreas , Heinemann Matthias 
Published: February 2023

AbstractMany cell biological and biochemical mechanisms controlling the fundamental process of eukaryotic cell division have been identified; however, the temporal dynamics of biosynthetic processes during the cell division cycle are still elusive. Here, we show that key biosynthetic processes are temporally segregated along the cell cycle. Using budding yeast as a model and single-cell methods to dynamically measure metabolic activity, we observe two peaks in protein synthesis, in the G1 and S/G2/M phase, whereas lipid and polysaccharide synthesis peaks only once, during the S/G2/M phase. Integrating the inferred biosynthetic rates into a thermodynamic-stoichiometric metabolic model, we find that this temporal segregation in biosynthetic processes causes flux changes in primary metabolism, with an acceleration of glucose-uptake flux in G1 and phase-shifted oscillations of oxygen and carbon dioxide exchanges. Through experimental validation of the model predictions, we demonstrate that primary metabolism oscillates with cell-cycle periodicity to satisfy the changing demands of biosynthetic processes exhibiting unexpected dynamics during the cell cycle.
Aquifer conditions, not irradiance determine the potential of photovoltaic energy for groundwater pumping across Africa
Authors: Meunier Simon , Kitanidis Peter K. , Cordier Amaury , MacDonald Alan M. 
Published: February 2023

AbstractGroundwater pumping using photovoltaic energy has the potential to transform water services in poorly served areas. Here we develop a numerical model that uses openly available data to simulate the abstraction capacities of photovoltaic water pumping systems across Africa. The first contribution of this article is the detailed design of the large-scale model to include realistic geological constraints on the depth of pumping and sub-hourly irradiance time series. The second one is the provision of results for the whole continent. We simulated results for three system sizes (100, 1000, 3000 Wp) and the daily pumped volumes were found to vary between 0.1 and 180 m3, depending on the size and location. We show that, for much of Africa, groundwater pumping using photovoltaic energy is constrained by aquifer conditions, rather than irradiance. Our results can help identify regions where photovoltaic pumping has the highest potential and help target large scale investments.