bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PEMBERIAN TEH HIJAU (Camellia sinensis) TERHADAP KERUSAKAN STRUKTUR HISTOPATOLOGI JANTUNG TIKUS PUTIH JANTAN GALUR Sprague dawley YANG DIPAPAR UAP ROKOK ELEKTRONIK
Authors: Rendayu Ina , Susanti Susanti , Putri Ayu Darma 
Published: June 2023

Zat yang terkandung dalam rokok elektrik tetap memiliki efek merugikan bagi organ tubuh (termasuk jantung) melalui pembentukan radikal bebas. Salah satu tanaman yang memiliki efek antioksidan adalah teh hijau. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak teh hijau terhadap struktur histopatologi jantung tikus putih (Rattus norvegicus) jantan galur Sprague dawley yang di papar uap rokok elektrik. Penelitian ini merupakan penelitian eksperimental dengan pendekatan metode rancangan eksperimen sungguhan. Tiga puluh ekor tikus dibagi dalam enam kelompok (kontrol negatif dengan pemberian akuades (K1), kontrol positif dengan pemberian uap rokok elektrik (K2) dan uap rokok konvensional (K3), dan tiga kelompok perlakuan dengan dosis ekstrak teh hijau 50 mg/kg BB (P1), 100 mg/kg BB (P2) dan 200 mg/kg BB (P3)). Hasil penelitian menunjukkan kerusakan struktur miokardium tikus putih akibat paparan uap rokok elektrik hampir sama dengan rokok konvensional. Pemberian ekstrak teh hijau tidak berpengaruh terhadap struktur histopatologi jantung tikus putih yang diberikan paparan uap rokok elektrik. Tidak terdapat pengaruh pemberian ekstrak teh hijau terhadap struktur histopatologi jantung tikus putih (Rattus norvegicus) jantan galur Sprague dawley yang diberikan paparan uap rokok elektrik.
KADAR SEL LEUKOSIT DAN ERITROSIT SELAMA TERAPI RADIASI PADA PASIEN KANKER NASOFARING DI INSTALASI RADIOTERAPI RSUD PROVINSI NUSA TENGGARA BARAT
Authors: Astina Kadek Yuda , Kusuma Ardani Ni Made Ary Esty , Daksa Ngakan Putu 
Published: June 2023

Abstrak: Kadar Sel Leukosit dan Eritrosit Selama Terapi Radiasi Pada Pasien Kanker Nasofaring. Karsinoma nasofaring merupakan tumor ganas yang berasal dari sel epitel pada nasofaring. Karena lokasi anatominya yang kompleks dan radiosensitivitasnya yang tinggi, radioterapi (RT) merupakan pengobatan yang direkomendasikan. Salah satu efek dari radioterapi adalah terganggunya proses pembentukan sel darah. Tujuan penelitian ini adalah untuk menganalisis kadar sel leukosit dan sel eritrosit selama terapi radiasi pada pasien kanker nasofaring di Instalasi Radioterapi RSUD NTB periode tahun 2020-2021. Metode: Penelitian ini merupakan penelitian kuantitatif yang menggunakan data retrospektif dengan sampel seluruh pasien kanker nasofaring yang telah menjalani terapi radiasi di Instalasi Radioterapi RSUD NTB dan telah melakukan tes laboratorium darah lengkap selama periode 2020-2021 yang akan dilakukan pencatatan jumlah kadar leukosit dan eritrosit dari data hasil pemeriksaan laboratorium darah lengkap yang terdapat pada rekam medis pasien kanker nasofaring di Instalasi Radioterapi RSUD NTB. Hasil: Dari 18 sampel yang digunakan didapatkan hasil dari uji friedman mengenai perbedaan kadar sel leukosit pada pasien kanker nasofaring selama menjalani terapi radiasi menunjukkan hasil p value sebesar 0,906, dan dari hasil uji repeat anova mengenai perbedaan kadar sel eritrosit pada pasien kanker nasofaring selama menjalani terapi radiasi menunjukkan hasil p value sebesar 0,928. Kesimpulan: Tidak terjadi perbedaan yang signifikan terhadap kadar sel darah leukosit maupun sel darah eritrosit pada pasien kanker nasofaring selama terapi radiasi di Instalasi Radioterapi RSUD Provinsi NTB periode tahun 2020-2021.
Analisis Faktor yang Berhubungan dengan Ketidakpatuhan Diet pada Pasien DM Tipe 2 di Rumah Sakit Umum Royal Prima Medan
Authors: Halawa Afeus , Gea Niat Hati , Bestheida Meliana 
Published: June 2023

ABSTRACT Diabetes is a chronic disease that cannot be cured due to the body's inability to properly process glucose into energy. The prevalence of diabetes in Indonesia in 2013 aged >15 years reached 15%, slightly lower than the prevalence in 2018 age> 15 years which is equal to 2.0%. Compliance with the treatment of people with Diabetes Mellitus is a patient's behavior in taking medication, following a diet, or following lifestyle changes. The research instrument used questionnaires and observation sheets with data collection methods through secondary data and premier data through an interview process with a sample of 30 people. The purpose of this study was to determine the analysis of factors related to dietary adherence in Diabetes Mellitus sufferers at the Royal Prima Medan General Hospital in 2023. Based on the results of the chi square test, it shows that there is an influence on the relationship of dietary noncompliance in Diabetes Mellitus sufferers with a p-value of 0.000 <0.005 so it can be interpreted that Ho is rejected. Suggestions to respondents are hoped that this research can improve dietary compliance in Diabetes Mellitus patients. Keywords: Diabetes Mellitus, Dietary compliance ABSTRAK Ketidakmampuan tubuh untuk mengubah glukosa menjadi energi dengan tepat membuat diabetes menjadi kondisi kronis yang tidak bisa disembuhkan. Di Indonesia, prevalensi diabetes pada usia 15 tahun ke atas ialah 15% saat 2013, dan 2,0% saat 2018. Tindakan pasien dalam menerima pengobatan, menjaga pola makan, atau mengadopsi kebiasaan baru yang dianjurkan sebagai bagian dari pengelolaan DM ialah ukuran ketaatan. Kuesioner dan lembar observasi merupakan alat pengumpul data primer, dilengkapi dengan data sekunder dari sumber yang ada dan wawancara dengan total 30 partisipan. Riset ini bertujuan untuk menganalisis variabel yang berkontribusi terhadap kebiasaan makan yang buruk pada individu di RSU Royal Prima Medan yang menderita DMT saat 2023. Hasil uji chi-square menampilkan bahwasanya ditemukan relasi bersignifikan antara ketidakpatuhan diet dengan diabetes mellitus. , dan p-value ialah 0,000 kurang daripada 0,005, maka begitu Ho ditolak. Diinginkan dengan memberikan saran kepada responden, riset ini dapat mengarah pada ketaatan diet yang lebih baik di antara mereka yang menderita Diabetes Mellitus. Kata Kunci: Diabetes Melitus, Kepatuhan Diet
Early postoperative PTH level following total thyroidectomy as a predictor of hypocalcemia: a single center-based study in Bangladesh
Authors: Hoque Emdadul , Hamid Kawser , Sakil Riaz Ahmed , Bhuiyan Haroun or Rashid 
Published: June 2023

Background: Assessment of parathyroid hormone (PTH) following thyroid surgery assists in the prediction of hypocalcemia and permits early intervention and therapy with oral calcium and/or vitamin D supplements.
Methods: This retrospective analysis comprised 141 individuals who had undergone a total or completion thyroidectomy over the previous four years. The blood PTH level was measured 3 hours after surgery to determine its change and to predict hypocalcemia.
Results: Patients were predominately female (75.2%), and the mean age was 48.73 ± 13.44 years. The main surgical procedure was total thyroidectomy (80.14%), and the main cause for surgery was a multinodular goiter (34.04%). A comparable number of patients with each type of thyroid disease (multinodular goiter, papillary thyroid cancer, thyroiditis, Graves’ disease or toxic multinodular goiter were enrolled. Three hours after surgery 93 patients (65.95%) had serum PTH levels of >10 pg/ml (mean 28.06) and 90 patients (68.38%) had normal serum calcium (mean 8.66). Most of these 93 patients (65.95%) didn't require postoperative supplementation, whereas 48 patients (34.05 %) with serum PTH levels less than 10 pg/ml required some form of supplementation; 39 (27.65 %) required both oral calcium and vitamin D supplements, and 9 (6.4 %) required only oral vitamin D supplementation. There was a significant correlation between the 3-h postoperative PTH level and hypocalcemia (P-value 0.000). The type of pathology had no significant association with low serum PTH level after surgery (P-value 0.166).
Conclusion: Asymptotic individuals with PTH levels less than 10 pg/ml, who are regarded as being in the high-risk category, can start taking calcium and/or vitamin D supplements early if their PTH levels are measured at 3 hours following complete thyroidectomy. To predict hypocalcemia, more research is required to compare the outcome of early serum PTH level with the day one serum PTH level following complete thyroidectomy.
Central Medical College Journal Vol 6 No 2 Jauly 2022 Page: 82-89
Predictors of 6-month follow-up Outcome of Drug Treatment in Schizophrenia in a tertiary hospital of Bangladesh
Authors: Ullah Mohammad Shahid , Pathan Mohammad Asraful Siddike , Imam Sheikh Muhammad Ali , Khaled MS , Ahmed Helal Uddin 
Published: June 2023

Background: Schizophrenia may have a better outcome in low- and middle-income countries. In Bangladesh short-term outcome of drug treatment of schizophrenia is also better. It is required to see the predictors of outcome of drug treatment of schizophrenia in Bangladesh.
Objectives: General objective of this study is to assess the outcome of 6-month follow-up of patients with schizophrenia. Specific objective of this study is to find out the predictors of 6-month follow-up outcome of drug treatment in schizophrenia.
Methods: Patients with a SCID-1/P diagnosis of schizophrenia (n=42) were assessed prospectively at baseline, at 6-week and at 6-month follow-up. Socio-demographic and relevant variables and questionnaire for family support and previous work record for the study were read in front of the patients and guardians and were filled up by the researcher. Psychopathological measurements were applied at base line by researcher and at 6-week and at 6-month by research assistant for the study population.
Results: Follow-up data were available for 38 patients at 6-month and among them 86.85% achieved partial remission, 7.89% had not responded and 5.26% had relapsed. In multivariate analysis by General Linear Model Analysis of socio-demographic and relevant variables with the mean BPRS score as outcome in this study we found that age, education, marital status and history of previous work record were significantly associated with the 6-month treatment outcome. Conclusions: Drug treatment outcome of schizophrenia in Bangladesh is better in short-term follow-up. Increase family support and early management by drugs should be a target for intervention.
Central Medical College Journal Vol 6 No 2 Jauly 2022 Page: 90-96
Nuances de Cor: desvendando o espaço escolar através dos olhos da mulher negra – uma investigação das representações imagéticas em livros didáticos de Ciências naturais no norte do Ceará, Brasil
Authors: Barros Diego Matos Araujo , Silva Eduardo Diniz Sousa e , Bonfim Gurhgel Presley Gomes , Araújo Evilândia Alves , Damasceno Gerviz Fernandes de Lima , Kokay Raquel Almeida de Carvalho , Matos Maria Madalena Pereira Barros 
Published: June 2023

Esta pesquisa bibliográfica e documental teve como objetivo analisar as representações da mulher negra nos livros didáticos de Ciências do PNLD/2017, utilizados na rede pública municipal de educação de Itapiúna, Ceará[1]. Focand na coleção“Ciências Naturais: Aprendendo com o Cotidiano”, foram examinadas as iconografias das capas, aberturas de unidades e imagens relacionadas às temáticas, utilizando como referências o Parecer 03/CNE/CP/2004, Chartier e categorias como raça, racismo, preconceito, discriminação racial e identidade negra. A pesquisa é um recorte de um estudo de mestrado concluído em 2021 no Programa de Pós-graduação Interdisciplinar em Humanidades da Unilab-CE, utilizando a Análise de Conteúdo de Bardin. Os resultados obtidos demonstram uma baixa representatividade da mulher negra seguida por uma frequência mais intensa da mulher branca na coleção analisada. Além disso, observou-se na investigação um “alinhamento” pontual das representações imagéticas da mulher negra com relação aos três princípios presentes no Parecer CNE/CP 003/2004: “consciência política e histórica da diversidade”, “fortalecimento de identidades e direitos”, e “ações educativas de combate ao racismo e às discriminações”.
Relações da hidratação no período pré e pós competições em atletas de artes marciais: revisão narrativa da literatura
Authors: Souza Gabriel Moreira de , Carvalho João Victor Costa Pontes , Maynard Dayanne da Costa 
Published: June 2023

No meio das modalidades de artes marciais, temos a divisão de cada categoria pelo peso corporal dos atletas. Visando buscar uma maior vantagem do mecanismo de aferição dos pesos, atletas tendem a baixar o peso abruptamente para então, no dia da competição, estarem com um peso maior que seu oponente trazendo assim uma certa vantagem. Os métodos de perda de peso rápido são agressivos e podem trazer diversas ameaças à saúde do atleta. Assim sendo, esta revisão teve o objetivo de avaliar os estudos relacionados a hidratação dos competidores de artes marciais, e os impactos possíveis na saúde do atleta e sua performance no esporte, as formas de perda de peso e desidratação utilizadas. Foi encontrado que uma perda de peso rápida maior que 5% da massa corporal total traz piora significativa para a performance, marcadores bioquímicos e aspectos psicológico no atleta, essa piora é acentuada quando se é utilizado mais de um método para perda de peso rápida.
Innovation, Automation and Informatics Improves Quality in Lerdsin Hospital, Thailand
Authors: Karnchanaphiboonwong Adchada , Sringam Patcharawadee , Niwattakul Kawinna , Krommuang Teerayut , Gammie Alistair 
Published: June 2023

This paper describes a planned, continuous improvement journey, of a laboratory that has installed a system with a single sample touch from blood draw to result. To achieve this, physical connectivity of systems from phlebotomy through pre-analytical to the analytical phase were paired with informatics connectivity from the patient’s national identity card to the hospital and laboratory informatics management systems (LIMS) and associated middleware. This allowed accurate time stamps to track turnaround time (TAT). TAT metrics were collected from the LIMS for inpatient, emergency room and outpatient samples and tests over a period of 7 months. This time span incorporated the 2-month period before automation was implemented. The results for all tests and specific tests are shown and the results of an analysis of the outpatient phlebotomy workflow are given. The implemented solution has improved outpatient TAT by over 54% and has shown that samples can be collected, and results obtained without touching the sample. Improving intra-laboratory TAT is an important quality goal for all laboratories. The implementation of automation is important in achieving this albeit more about obtaining predictable TAT. Automation does not necessarily improve TAT it removes variation which leads to predictable TAT (PTAT). Automation should only be considered with a strategic vision for the future as it is important to have clear goals and objectives based on the individual laboratories process and needs. Automating a poor process leads to an automated poor process. Here, an innovative use of automation, hardware and software has resulted in marked improvement in TAT across all samples processed in the central laboratory.
Remote monitoring titration clinic to implement guideline-directed therapy for heart failure patients with reduced ejection fraction: a pilot quality-improvement intervention
Authors: Romero Erick , Yala Stella , Sellers-Porter Camryn , Lynch Genevieve , Mwathi Veronicah , Hellier Yvette , Goldman Svetlana , Rocha Paulo , Fine Jeffrey R. , Liem David , Bidwell Julie T. , Ebong Imo , Gibson Michael , Cadeiras Martin 
Published: June 2023

IntroductionGuideline-directed medical therapy (GDMT) is the recommended treatment for heart failure with reduced ejection fraction (HFrEF). However, the implementation remains limited, with suboptimal use and dosing. The study aimed to assess the feasibility and effect of a remote monitoring titration program on GDMT implementation.MethodsHFrEF patients were randomly assigned to receive either usual care or a quality-improvement remote titration with remote monitoring intervention. The intervention group used wireless devices to transmit heart rate, blood pressure, and weight data daily, which were reviewed by physicians and nurses every 2–4 weeks. Medication tolerance was assessed via phone, and dosage instructions were given. This workflow was repeated until target doses were reached or further adjustments were not tolerated. A 4-GDMT score measured use and target dosage, with the primary endpoint being the score at 6 months follow-up.ResultsBaseline characteristics were similar (n = 55). A median of 85% of patients complied with transmitting device data every week. At the 6-month follow-up, the intervention group had a 4-GDMT score of 64.6% compared to 56.5% in the usual care group (p = 0.01), with a difference of 8.1% (95% CI: 1.7%–14.5%). Similar results were seen at the 12-month follow-up [difference 12.8% (CI: 5.0%–20.6%)]. The intervention group showed a positive trend in ejection fraction and natriuretic peptides, with no significant difference between groups.ConclusionsThe study suggests that a full-scale trial is feasible and that utilizing a remote titration clinic with remote monitoring has the potential to enhance the implementation of guideline-directed therapy for HFrEF.
Characteristics and controls of an offshore freshened groundwater system in the Shengsi region, East China Sea
Authors: Thomas Ariel T. , Micallef Aaron , Duan Shuangmin , Zou Zhihui 
Published: June 2023

Offshore freshened groundwater (OFG) has been encountered in continental margins around the world and identified as a potential unconventional water resource. In China, coastal areas and islands face limited freshwater resources. The East China Sea, specifically the region north of Shengsi islands, may contain an OFG system hosted in buried paleochannels associated with the ancient Yangtze river. To assess the OFG potential, characteristics, and controls in this region, we employed an integrated modeling approach. We constructed a 2D geological model of Quaternary sediments based on data from two well sites. By considering sea-level fluctuations over the past 200,000 years, we conducted a paleo-reconstruction of groundwater flow and solute transport conditions on the 2D transect. We compared the simulated present-day distribution of OFG in the model with borehole observations. Our findings indicate that the region was mostly sub-aerially exposed during the simulated period, allowing for potential meteoric recharge. Numerical results demonstrate a high likelihood of a laterally extensive OFG system existing today. The mechanism responsible for its formation appears to be meteoric recharge and offshore directed groundwater flow caused by increased hydraulic gradients during sea-level lowstand. The model suggests that the OFG system forms an oceanward dipping wedge, with the top occurring approximately 50–100 m below the seafloor. Freshwater is likely present down to the basement at around 250 m. The geometry and volume of the OFG system are strongly influenced by the shelf stratigraphy. We estimate the volume of freshwater in the region to range from 0.5 to 1.6 km3 km-1, indicating a viable potential freshwater resource for the Shengsi region and coastal city of Shanghai. To gain further insights, we recommend conducting additional investigations using geophysical techniques.
Comparison of frozen-thaw blastocyst transfer strategies in women aged 35–40 years: a retrospective study
Authors: Wu Yanhong , Lu Xiaosheng , Chen Haoying , Fu Yanghua , Zhao Junzhao 
Published: June 2023

ObjectiveTo compare the effects of five different frozen-thaw embryo transfer (FET) strategies in women aged 35–40 years.MethodsData from 1,060 patients were divided into five groups according to the number and quality of transferred blastocysts: a high-quality single blastocyst group (group A, n= 303), a high-quality double blastocysts group (group B, n= 176), a high-quality plus poor-quality double blastocysts group (group C, n= 273), a poor-quality double blastocysts group (group D, n= 189), and a poor-quality single blastocyst group (group E, n= 119). Comparative analyses were then performed between groups with regard to primary conditions, pregnancy, and neonatal outcomes.ResultsGroup A had the lowest twin pregnancy rate (1.97%) and incidence of low-birth-weight infants (3.45%), which were significantly different from groups B, C, and D. In addition, the preterm birth rate (7.89%), neonatal birth weight (3300 g [3000, 3637.5]), and neonatal birth age (39.14 weeks [38.43, 39.61]) in group A were different from those in groups B and C. Double blastocyst transfer (DBT) was associated with a 20.558-fold (Risk Ratio [RR]=20.558, 95% confidence interval [CI], 6.628–63.763) and 3.091-fold (RR=3.091, 95% CI, 1.69–5.653) increased risk of twin pregnancy and preterm delivery in unadjusted analysis, respectively, when compared with single blastocyst transfer (SBT). In the adjusted analysis, we observed similar risk estimates (adjusted RR=26.501, 95% CI, 8.503–82.592; adjusted RR=3.586, 95% CI, 1.899–6.769).ConclusionAlthough, high-quality SBT resulted in a lower live birth rate than high-quality DBT, it also significantly reduced the risk of adverse pregnancies, thus resulting in more benefits for both the mother and baby. Collectively, our data indicate that high-quality SBT remains the optimal FET strategy for women aged 35–40 years and warrants further clinical application.
Cancer mortality distribution in South Africa, 1997–2016
Authors: Nhleko Mandlakayise Lucky , Edoka Ijeoma , Musenge Eustasius 
Published: June 2023

IntroductionThe mortality data in South Africa (SA) have not been widely used to estimate the patterns of deaths attributed to cancer over a spectrum of relevant subgroups. There is no research in SA providing patterns and atlases of cancer deaths in age and sex groups per district per year. This study presents age-sex-specific geographical patterns of cancer mortality at the district level in SA and their temporal evolutions from 1997 to 2016.MethodsIndividual mortality level data provided by Statistics South Africa were grouped by three age groups (0–14, 15–64, and 65+), sex (male and female), and aggregated at each of the 52 districts. The proportionate mortality ratios (PMRs) for cancer were calculated per 100 residents. The atlases showing the distribution of cancer mortality were plotted using ArcGIS. Spatial analyses were conducted through Moran's I test.ResultsThere was an increase in PMRs for cancer in the age groups 15–64 and 65+ years from 2006 to 2016. Ranges were 2.83 (95% CI: 2.77–2.89) −4.16 (95% CI: 4.08–4.24) among men aged 15–64 years and 2.99 (95% CI: 2.93–3.06) −5.19 (95% CI: 5.09–5.28) among women in this age group. The PMRs in men and women aged 65+ years were 2.47 (95% CI: 2.42–2.53) −4.06 (95% CI: 3.98–4.14), and 2.33 (95% CI: 2.27–2.38) −4.19 (95% CI: 4.11–4.28). There were considerable geographical variations and similarities in the patterns of cancer mortality. For the age group 15–64 years, the ranges were 1.18 (95% CI: 0.78–1.71) −8.71 (95% CI: 7.18–10.47), p &lt; 0.0001 in men and 1.35 (95% CI: 0.92–1.92) −10.83 (95% CI: 8.84–13.14), p &lt; 0.0001 in women in 2016. There were higher PMRs among women in the Western Cape, Northern Cape, North West, and Gauteng compared to other areas. Similar patterns were also observed among men in these provinces, except in North West and Gauteng.ConclusionThe identification of geographical and temporal distributions of cancer mortality provided evidence of periods and districts with similar and divergent patterns. This will contribute to understanding the past, present, future trends and formulating interventions at a local level.