bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities in treatment and outcome of kidney replacement therapy in children with comorbidities: an ESPN/ERA Registry study
Authors: Schild Raphael , Dupont Simeon , Harambat Jérôme , Vidal Enrico , Balat Ayşe , Bereczki Csaba , Bieniaś Beata , Brandström Per , Broux Francoise , Consolo Silvia , Gojkovic Ivana , Groothoff Jaap W , Hommel Kristine , Hubmann Holger , Braddon Fiona E M , Pankratenko Tatiana E , Papachristou Fotios , Plumb Lucy A , Podracka Ludmila , Prokurat Sylwester , Bjerre Anna , Cordinhã Carolina , Tainio Juuso , Shkurti Enkelejda , Spartà Giuseppina , Vondrak Karel , Jager Kitty J , Oh Jun , Bonthuis Marjolein 
Published: January 2023

ABSTRACTBackgroundData on comorbidities in children on kidney replacement therapy (KRT) are scarce. Considering their high relevance for prognosis and treatment, this study aims to analyse the prevalence and implications of comorbidities in European children on KRT.MethodsWe included data from patients &lt;20 years of age when commencing KRT from 2007 to 2017 from 22 European countries within the European Society of Paediatric Nephrology/European Renal Association Registry. Differences between patients with and without comorbidities in access to kidney transplantation (KT) and patient and graft survival were estimated using Cox regression.ResultsComorbidities were present in 33% of the 4127 children commencing KRT and the prevalence has steadily increased by 5% annually since 2007. Comorbidities were most frequent in high-income countries (43% versus 24% in low-income countries and 33% in middle-income countries). Patients with comorbidities had a lower access to transplantation {adjusted hazard ratio [aHR] 0.67 [95% confidence interval (CI) 0.61–0.74]} and a higher risk of death [aHR 1.79 (95% CI 1.38–2.32)]. The increased mortality was only seen in dialysis patients [aHR 1.60 (95% CI 1.21–2.13)], and not after KT. For both outcomes, the impact of comorbidities was stronger in low-income countries. Graft survival was not affected by the presence of comorbidities [aHR for 5-year graft failure 1.18 (95% CI 0.84–1.65)].ConclusionsComorbidities have become more frequent in children on KRT and reduce their access to transplantation and survival, especially when remaining on dialysis. KT should be considered as an option in all paediatric KRT patients and efforts should be made to identify modifiable barriers to KT for children with comorbidities.
Drug-coated balloon angioplasty, intraoperatively through left anterior descending arteriotomy access, a novel hybrid revascularization strategy: a case report
Authors: Javed Asim , Siddiqueh Musfireh , Anjum Qudsia , Jalal Anjum 
Published: January 2023

Abstract

Background
Patients undergoing coronary artery bypass graft (CABG) sometimes have critical proximal lesion in left anterior descending (LAD) artery or chronic total occlusion followed by either skip lesions or diffuse disease of late mid-to-distal LAD artery. Such lesions require endarterectomy or atheroma bridging via long venous or arterial patch (patch-plasty), for which clinical outcomes are conflicting in studies due to a more thrombogenic milieu created by patch-plasty as well as incomplete endarterectomy. We present a hybrid approach with drug-coated balloon (DCB) angioplasty of mid-to-distal LAD through LAD arteriotomy followed by left internal mammary artery (LIMA) insertion to LAD.

Case summary
A 35-year-old man who was thrombolyzed for anterior wall myocardial infarction in another city, reported to our hospital four weeks later with persistent angina. Coronary angiography showed severe multivessel coronary artery disease. There was diffuse disease in LAD distal to potential site of LIMA insertion and needed patch-plasty. We carried out a hybrid procedure by performing DCB angioplasty of mid-to-distal LAD through the LAD arteriotomy site during CABG followed by LIMA insertion to the LAD. The patient remained asymptomatic post procedure with a 6-month follow-up computerized tomography scan showing patent LIMA and mid-to-distal LAD.

Discussion
This case shows a novel technique, first in the world, of performing angioplasty during CABG through arteriotomy followed by graft insertion.
Sex differences in type A acute aortic dissection: a systematic review and meta-analysis
Authors: Carbone Andreina , Ranieri Brigida , Castaldo Rossana , Franzese Monica , Rega Salvatore , Cittadini Antonio , Czerny Martin , Bossone Eduardo 
Published: January 2023

Abstract

Background
In acute aortic dissection (AAD) sex heterogeneity reports are not exhaustive and in part even conflicting.

Aims
To explore sex differences in clinical features, management, and outcomes among patients with type A AAD.

Methods and results
A systematic review and meta-analysis of the literature were conducted for studies (2004–2022) reporting type A AAD sex differences. Among the 1938 studies retrieved, 16 (16 069 patients, 7142 women, and 8927 men) fulfilled all eligibility criteria. Data were aggregated used the random-effects model as pooled risk ratio and mean difference. Due to information reported by considered manuscripts, analysis were performed only among surgically treated type A AAD patients. At the time of hospital presentation type A AAD women were older than men but had lower body mass index (BMI), body surface area (BSA), and creatinine plasma levels. Active smoking, bicuspid aortic valve, and previous cardiac surgery were less common in women while diabetes mellitus was more frequent. Furthermore, women experienced more frequently pericardial effusion/cardiac tamponade than men. Interestingly, in-hospital surgical mortality did not differ between sexes [risk ratio (RR), 1.02; 95% confidence interval (CI), 0.53–1.99; P = 0.95], whereas 5 (RR 0.94; 95% CI: 0.92–0.97; P &lt; 0.001) and 10-year survival (RR 0.82; 95% CI: 0.74–0.92; P = 0.004) was higher among men. A descriptive analysis of in-hospital outcomes among medically treated type A AAD patients confirmed prohibitive high mortality for both sexes (men 58.6% vs. women 53.8%, P = 0.59).

Conclusions
A female sex phenotype appears to be evident in type A AAD implying the need for a personalized management patient approach along with tailored preventive strategies.

PROSPERO registry ID
CRD42022359072.
Resveratrol Alleviates Inflammation and ER Stress Through SIRT1/NRF2 to Delay Ovarian Aging in a Short-Lived Fish
Authors: Zhu Hongyan , Li Xiaowen , Qiao Mengxue , Sun Xiaowen , Li Guorong 
Published: January 2023

AbstractAging is a complex process in which the structure and function of various tissues and organs gradually decline with age, and ovarian aging affects the reproductive capacity of females and induces age-related diseases. Resveratrol, a natural polyphenol compound, extends the life span and has a protective effect on the ovaries of vertebrates. However, the effects and underlying mechanisms of resveratrol delaying ovarian aging are unclear. In this study, using an annual fish Nothobranchius guentheri, we demonstrated that senescence-associated-beta-galactosidase (SA-β-gal) activity and lipofuscin accumulation increased with age in the ovaries, and resveratrol reversed this phenomenon. Resveratrol increased proliferating cell nuclear antigen (PCNA) expression and the oocyte proportions of the primary growth stage, cortical alveolus stage and vitellogenesis stage, and decreased the number of atretic follicles in the ovaries of 6-, 9-, and 12-month-old fish. Moreover, the expression of SIRT1 and NRF2 decreased and the levels of NF-κB, pro-inflammatory cytokines IL-1β, TNF-α, and IL-8 and endoplasmic reticulum (ER) stress markers GRP78 and CHOP increased with aging, while resveratrol up-regulated SIRT1 and NRF2 expression and down-regulated NF-κB, IL-1β, TNF-α, IL-8, GRP78, and CHOP levels in the ovaries of 6- and 9-month-old fish. In HEK293T cells, knockdown SIRT1 decreased NRF2 and increased NF-κB p65, pro-inflammatory cytokines (IL-1β and TNF-α), and ER stress marker GRP78 expression markedly. Silencing SIRT1 and then treating the cells with resveratrol significantly reversed the phenomenon. Collectively, resveratrol might activate SIRT1/NRF2 to reduce inflammation and ER stress, and finally delay ovarian aging in a short-lived fish. This study highlights the protective effect and mechanism of resveratrol on ovarian aging.
Body Mass Index and Cognition: Associations Across &#x2028;Mid- to Late Life and Gender Differences
Authors: Crane Breanna M , Nichols Emma , Carlson Michelle C , Deal Jennifer A , Gross Alden L 
Published: January 2023

AbstractBackgroundHigher mid-life body mass index (BMI) is associated with lower late-life cognition. Associations between later-life BMI and cognition are less consistent; evidence suggests reverse causation may play a role. We aimed to characterize associations between BMI and cognition across a wide age range during mid- to late life (55–85 years) and examine whether associations vary by gender.MethodsWe used data from the Health and Retirement Study (HRS) (N = 39,153) to examine the association between BMI and 3 cognitive outcomes: cognitive level, cognitive decline, and cognitive impairment. We used a series of linear regression, mixed effects regression, and logistic regression models, adjusting for potential confounders.ResultsHigher BMI before age 65 (midlife) was associated with lower cognitive performance, faster rates of cognitive decline, and higher odds of cognitive impairment in late life. Averaging across analyses assessing associations between BMI measured before age 60 and late-life cognition, a 5-unit higher level of BMI was associated with a 0.26 point lower cognitive score. Beyond age 65, associations flipped, and higher BMI was associated with better late-life cognitive outcomes. Associations in both directions were stronger in women. Excluding those with BMI loss attenuated findings among women in older ages, supporting the reverse causation hypothesis.ConclusionsIn this sample, age 65 represented a critical turning point between mid- and late life for the association between BMI and cognition, which has important implications for recruitment strategies for studies focused on risk factors for late-life cognitive outcomes. Evidence of gender differences raises the need to further investigate plausible mechanisms.
Coping Styles and Cognitive Function in Older Non-Hispanic Black and White Adults
Authors: Lee Ji Hyun , Sol Ketlyne , Zaheed Afsara B , Morris Emily P , Meister Lindsey M , Palms Jordan D , Zahodne Laura B 
Published: January 2023

Abstract

Objectives
Coping styles refer to cognitive and behavioral patterns used to manage the demands of stressors, and effective coping represents a psychological resource. Some studies have linked coping styles to executive functioning, but less is known about coping styles and their associations with cognition across social groups known to differ in stress exposure and dementia risk. This study aimed to characterize associations between coping styles and cognitive functioning across non-Hispanic Black and non-Hispanic White older adults.

Methods
Participants were drawn from the Michigan Cognitive Aging Project (N = 453; age mean (SD) = 63.6 (3.2); 53% non-Hispanic Black). Problem-focused and emotion-focused coping were measured using the Coping Orientation to Problems Experienced Inventory. Global cognition was a composite of 5 cognitive domain scores derived from comprehensive neuropsychological tests. Cross-sectional associations between coping styles and cognition were examined using race-stratified regressions controlling for demographic and health covariates.

Results
Black older adults reported more emotion-focused coping than White older adults, but there were no race differences in problem-focused coping. Among Black older adults, less problem-focused coping and more emotion-focused coping were each associated with worse cognition. Among White older adults, emotion-focused coping was marginally linked to cognition.

Discussion
Greater emotion-focused coping among Black older adults may reflect greater exposure to stressors that are uncontrollable. Patterns of racial differences in coping–cognition links are in line with the social vulnerabilities hypothesis. Coping style may be a particularly important psychosocial resource for cognitive health among Black older adults that could be incorporated into culturally relevant interventions.
Jasmonic acid regulates the biosynthesis of medicinal metabolites via the JAZ9-MYB76 complex inSalvia miltiorrhiza
Authors: Liu Shucan , Gao Xiankui , Shi Min , Sun Meihong , Li Kunlun , Cai Yan , Chen Chengan , Wang Can , Maoz Itay , Guo Xinhong , Kai Guoyin 
Published: January 2023

AbstractJasmonic acid (JA) signaling pathway plays an important role in tanshinone and phenolic acid biosynthesis in Salvia miltiorrhiza. However, the specific regulatory mechanism remains largely unclear. Previous work showed that a JASMONATE ZIM-domain (JAZ) protein, SmJAZ9, acted as a repressor of tanshinone production in S. miltiorrhiza. In this study, we revealed that SmJAZ9 reduced both phenolic acid accumulation and related biosynthetic gene expression, confirming that SmJAZ9 also negatively affected phenolic acid biosynthesis. Then, we identified a novel MYB transcription factor, SmMYB76, which interacted with SmJAZ9. SmMYB76 repressed phenolic acid biosynthesis by directly downregulating SmPAL1, Sm4CL2, and SmRAS1. Further investigation demonstrated that JA mediated phenolic acids biosynthesis via SmJAZ9-SmMYB76 complex. Taken together, these findings state the molecular mechanism that SmJAZ9-SmMYB76 regulated phenolic acid biosynthesis at the transcriptional and protein levels, which provided new insights into JA signaling pathway regulating plant metabolism.
A comparative assessment of combustion behavior and emissions characteristics of DI diesel engine fueled with waste plastic oil and eucalyptus biofuel for sustainable development applications
Authors: Naima Khatir , Bousbaa Hamza , Ahmad Hijaz , Al-Bahrani Mohammed , Tarabet Lyes , Menni Younes , Lorenzini Giulio 
Published: January 2023

Abstract
The increase in population growth rates led to a high rate of production and use of plastic materials, which created a problem in the collection and management of this waste [1]. This created severe threats to the environment and the ecosystem. The main objective of this paper is to conduct an experimental assessment of a direct diesel engine fueled with waste plastic oil (WPO), eucalyptus biofuel (EB) and conventional diesel. The engine operated in the same operating condition with all fuels. The results show that WPO has a shorter ignition delay, resulting in lower in-cylinder temperature and pressure than EB and diesel fuel. The brake thermal efficiency of WPO is significant over all the range of engine loading. Carbon monoxide emissions of WOP fuel are lower than diesel fuel and higher than EB oil. Nitrogen oxide emissions of WPO are lower at low and full loads but higher at medium load. Considerable decrease in unburned hydrocarbons and particulate matter emissions with EB compared with WPO and diesel fuels. The results of this study concluded that both fuels are considered a viable solution for achieving sustainably.
Study on low temperature phase change heat storage and its performance of solar and air source heat pump system
Authors: Zhan Hao , Wu Ronghua , Yu Hao , Liu Changqing , Li Kang 
Published: January 2023

Abstract
In view of the deterioration of the performance of air source heat pump at low temperature in cold regions and the large fluctuation of solar heating systems, a heat pump system with low-temperature heat storage using sodium chloride aqueous solution as the phase change thermal storage material is proposed. The system form and its operation scheme, unit energy consumption model and economic evaluation index are given. The influence of different concentrations of sodium chloride solution corresponding to different heat storage temperatures and different areas of solar collectors on the system operation economy is studied, and simulation analysis and optimization are carried out and the operation efficiency and operation economy of the system are analyzed with an actual residential building in a cold region as an example. The results show that with the increase of collector area, the lower the sodium chloride concentration, the higher the heat storage temperature and the higher the coefficient of performance (COP) of the system; the larger the collector area, the higher the COP of the system, but the payback period decreases first and then extends with the increase of the collector area. When the system sodium chloride solution concentration is 5.3% and the collector area is 372m2, there is a minimum payback period for the winter heating of 3000m2 building in this case, and at this time, the COP of the system is 2.37, which is 20% higher than that of the traditional air source heat pump. The payback period of the system is 7.7 years, and the contribution rate of the solar collector system is 53%. The solar air source heat pump system with low temperature phase change heat storage significantly improves the operation performance of the system and has good energy saving benefits.
A Rough Colony Morphology ofMycobacterium abscessusIs Associated With Cavitary Pulmonary Disease and Poor Clinical Outcome
Authors: Hedin Wilhelm , Fröberg Gabrielle , Fredman Kalle , Chryssanthou Erja , Selmeryd Ingrid , Gillman Anna , Orsini Letizia , Runold Michael , Jönsson Bodil , Schön Thomas , Davies Forsman Lina 
Published: January 2023

AbstractBackgroundThe Mycobacterium abscessus complex (MABC) is a difficult to treat mycobacterium with two distinct morphologies: smooth and rough. As the clinical implications are unclear, we explored the morphology of MABC in relation to disease and outcome.MethodsWe performed a retrospective multicenter cohort study including patients with confirmed MABC in Sweden, 2009–2020, with treatment outcome as the primary outcome. MABC colony morphology was determined by light microscopy on Middlebrook 7H10 agar plates.ResultsOf the 71 MABC isolates, a defined morphology could be determined for 63 isolates, of which 40 were smooth (56%) and 23 were rough (32%). Immunosuppression, pulmonary disease, and cavitary lesion on chest radiographs were significantly associated with a rough isolate morphology. Participants with smooth isolates had more favorable treatment outcomes (12/14, 86%) compared to those with rough isolates (3/10, 30%). In an age-adjusted logistic regression, rough morphology of MABC was associated to lower odds of clinical cure compared to smooth morphology (adjusted odds ratio, 0.12; P = .049).ConclusionsStudy participants with rough MABC colony morphology of isolates had a worse clinical outcome compared to those with smooth isolates. The biological mechanisms should be further characterized and colony morphology of MABC taken into account during clinical management.
Framing States: Unitary Actor Language and Public Support for Coercive Foreign Policy
Authors: Altier Mary Beth , Kane John V 
Published: January 2023

Abstract
A defining feature of public (and, often, scholarly) discussion of international affairs is the treatment of states as unitary actors, that is, akin to individual persons. Drawing upon social–psychological research, we theorize that such unitary actor (UA) framing increases the degree to which adversarial states are perceived as entitative—that is, as relatively united—and, thus, the perceived complicity of a country's people in their government's actions. We therefore hypothesize that UA framing increases citizens’ support for indiscriminate, coercive policies against target states. In a content analysis of US elite statements spanning three decades, we first establish that UA framing is exceedingly common, occurring in nearly two-thirds of all references to adversarial states. We then conduct a series of survey experiments on US adults, finding that, compared to frames in which a state is described as more factious and disunited, UA framing is associated with significantly greater willingness to impose harmful, indiscriminate economic sanctions and military strikes against target states. Our results highlight the utility and applicability of entitativity to political science research, and have important implications for the role of elite discourse in bolstering public support for hawkish foreign policymaking.
Design and Evaluation of an Authoring Platform for Therapeutic Digital Games
Authors: da Hora Rodrigues Kamila Rios , Elias Cardoso Verhalen Aline , Willian da Silva Jonattan , Marino Silva Tiago , Geurgas Zavarizz Rodrigo , de Almeida Neris Vânia Paula , Maia de Souza Paula 
Published: January 2023

Abstract
Therapeutic digital games aim to support rehabilitation treatments and help patients understand, motivate and persist in therapeutic practices. Although there are several therapeutic digital games available, their development highly depends on the involvement of computer science professionals. This paper’s contribution is about how RUFUS was designed as a platform to provide EUP (End-User Programming) for healthcare professionals. This platform enables these professionals to author digital games aiming at performing therapeutic activities with their patients and/or caregivers. The platform has a web interface for game authoring, currently composed of three different game mechanics, as well as the possibility of viewing interaction reports. It also encompasses a mobile app that displays the games created for patients. Participatory design techniques were used during the design and evaluation of the three games to engage different stakeholders and also empower healthcare providers. A preliminary evaluation of the RUFUS point to an easy-to-use design solution, but which still needs further testing to ensure intuitiveness for users who have no experience with games or with authoring interfaces.
Retracted: Suboptimal dalbavancin dosages in an adult with sickle-cell disease and glomerular hyperfiltration
Authors: Abdellaoui Salomé , Gregoire Matthieu , Dubert Marie , Cheminet Geoffrey , Arlet Jean-Benoît , Lafont Emmanuel 
Published: January 2023

Abstract
This article has been retracted. Please see: https://doi.org/10.1093/jac/dkad283
The Role of ICSID in International Economic Law
Authors: Kinnear Meg 
Published: January 2023

ABSTRACT
The International Centre for Settlement of Investment Disputes was established in 1966 as a facility for the resolution of international investment disputes. Today, it has 158 member states and has administered roughly 70% of all known investor-state cases. International Centre for Settlement of Investment Disputes has taken a leadership role in modernizing the procedures for investor-state dispute resolution, especially in the 2006 and 2022 amendments to those rules.