bluuebunny/crossref_metadata_2025_split huggingface dataset:
Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway
Authors: Zhang Qianqian , Yao Min , Qi Jiajia , Song Rui , Wang Lei , Li Jiacheng , Zhou Xian , Chang Dennis , Huang Qi , Li Lili , Wang Ning 
Published: May 2023

Introduction: Puerarin (PUE) is a natural compound isolated from Puerariae Lobatae Radix, which has a neuroprotective effect on IS. We explored the therapeutic effect and underlying mechanism of PUE on cerebral I/R injury by inhibiting oxidative stress related to the PI3K/Akt/Nrf2 pathway in vitro and in vivo.Methods: The middle cerebral artery occlusion and reperfusion (MCAO/R) rats and oxygen-glucose deprivation and reperfusion (OGD/R) were selected as the models, respectively. The therapeutic effect of PUE was observed using triphenyl tetrazolium and hematoxylin-eosin staining. Tunel-NeuN staining and Nissl staining to quantify hippocampal apoptosis. The reactive oxygen species (ROS) level was detected by flow cytometry and immunofluorescence. Biochemical method to detect oxidative stress levels. The protein expression related to PI3K/Akt/Nrf2 pathway was detected by using Western blotting. Finally, co-immunoprecipitation was used to study the molecular interaction between Keap1 and Nrf2.Results:In vivo and vitro studies showed that PUE improved neurological deficits in rats, as well as decreased oxidative stress. Immunofluorescence and flow cytometry indicated that the release of ROS can be inhibited by PUE. In addition, the Western blotting results showed that PUE promoted the phosphorylation of PI3K and Akt, and enabled Nrf2 to enter the nucleus, which further activated the expression of downstream antioxidant enzymes such as HO-1. The combination of PUE with PI3K inhibitor LY294002 reversed these results. Finally, co-immunoprecipitation results showed that PUE promoted Nrf2-Keap1 complex dissociation.Discussion: Taken together, PUE can activate Nrf2 via PI3K/Akt and promote downstream antioxidant enzyme expression, which could further ameliorate oxidative stress, against I/R-induced Neuron injury.
Bevacizumab loaded CalliSpheres® bronchial arterial chemoembolization combined with immunotherapy and targeted therapy for advanced lung adenocarcinoma
Authors: Liu Haitao , Li Yahua , Li Zongming , Han Xinwei , Ren Kewei 
Published: May 2023

Background: As a new drug delivery and embolization system, drug-eluted bronchial artery chemoembolization (DEB-BACE) can not only embolize the tumor blood supply artery but also load chemotherapy drugs and slowly release them into the local environment. Bevacizumab (BEV) combined with chemotherapy drugs has attained significant achievements in the first-line treatment of advanced non-squamous non-small cell lung cancer (NSCLC). The role of BEV-loaded DEB-BACE combined with immunotherapy and targeted therapy in patients with lung adenocarcinoma (LUAD) is unclear. This study was designed to evaluate the efficacy and safety of bevacizumab-loaded CalliSpheres® bronchial arterial chemoembolization combined with immunotherapy and targeted therapy in patients with lung adenocarcinoma.Methods: Nine patients with LUAD who received BEV-loaded CalliSpheres® BACE combined with immunotherapy and targeted therapy from 1 Jan 2021 to Dec 2021 were included in this study. The primary endpoint was the disease control rate (DCR) and the objective response rate (ORR). The secondary endpoints were the overall survival rates (OS) at 6 months and 12 months. The tumor response was evaluated according to the mRECIST standard. Safety was assessed by the occurrences of adverse events and the severity of the adverse events.Results: All patients received CalliSpheres® BACE loaded with BEV (200 mg) in combination with immunotherapy and targeted therapy. A total of nine patients received the BACE procedures 20 times, four of them received a third session of BACE, three underwent a second session of DEB-BACE, and two underwent one cycle of DEB-BACE. Partial response and stable disease were found in seven (77.8%), and two (22.2%) patients, respectively, 1 month after the last multimodal treatment. The ORR at 1, 3, 6, and 12 months was 77.8%, 66.7%, 44.4%, and 33.3%, respectively, while the DCR was 100%, 77.8%, 44.4%, and 33.3%, respectively. The OS rates at 6-and 12-month were 77.8% and 66.7%, respectively. There were no serious adverse events.Conclusion: BEV-loaded CalliSpheres® transcatheter bronchial arterial chemoembolization combined with immunotherapy and targeted therapy is a promising and well-tolerated treatment for patients with lung adenocarcinoma.
Eco-effective Sustainable Risk Assessment Model for homogeneous solid waste mortars based on the Cradle to Cradle paradigm
Authors: Cadenas Nigme , Vásquez Stanescu Carmen Luisa , Gómez-Caicedo Melva Inés , Gaitan-Angulo Mercedes , Briñez Torres Carlos Yesid 
Published: May 2023

IntroductionThe unrestricted use of non-renewable natural resources in masonry mortars and the rapid increase in solid waste contribute to the deterioration of the environment. It is a priority for the United Nations to promote growth without compromising the ability of new generations to attend to their own; for this purpose, 17 Sustainable Development Goals for all countries have been formulated. The present work arises from the need to propose a model to evaluate, in the design phase, homogeneous solid waste and total or partial substitutes for some of the components of the mortars used in the construction sector, based on the Cradle to Cradle paradigm, which has the objective of including improved materials for the health of living beings and the environment by establishing a circular system in the manufacture of mortars including only safe and healthy materials that can be reused with a guarantee of not affecting the health of living beings and the environment and contributing to sustainability.MethodsBased on the positivist epistemological current, projective documentary research begins by analyzing scientific publications that recommend the use of solid waste only to verify its rheological properties, ignoring how the inclusion of this material can affect living beings and the environment; it is contrasted with the results of published public access research regarding the chemical substances that make up said material.ResultsThe eco-effective model is designed and its application is validated in identifying potential risks to the health of living beings and the environment in the waste of the selected cases; recommending the avoidance of recycling those materials that cause concern; contributing improved mortar designs for living beings and the planet, which minimize the use of natural resources and increase productivity in the field of construction; and implementing this vision through continuous development and improvement.ConclusionsThe eco-effective model facilitates doing the right things from the design stage, promoting growth with opportunities, diversity, and abundance for the present generation as well as future generations.
Characterization and Homology Modeling of Catalytically Active Recombinant PhaCAp Protein from Arthrospira platensis
Authors: Duangsri Chanchanok , Salminen Tiina A. , Alix Marion , Kaewmongkol Sarawan , Akrimajirachoote Nattaphong , Khetkorn Wanthanee , Jittapalapong Sathaporn , Mäenpää Pirkko , Incharoensakdi Aran , Raksajit Wuttinun 
Published: May 2023

Polyhydroxybutyrate (PHB) is a biocompatible and biodegradable polymer that has the potential to replace fossil-derived polymers. The enzymes involved in the biosynthesis of PHB are β-ketothiolase (PhaA), acetoacetyl-CoA reductase (PhaB), and PHA synthase (PhaC). PhaC in Arthrospira platensis is the key enzyme for PHB production. In this study, the recombinant E. cloni ®10G cells harboring A. platensis phaC (rPhaCAp) was constructed. The overexpressed and purified rPhaCAp with a predicted molecular mass of 69 kDa exhibited Vmax, Km, and kcat values of 24.5 ± 2 μmol/min/mg, 31.3 ± 2 µM and 412.7 ± 2 1/s, respectively. The catalytically active rPhaCAp was a homodimer. The three-dimensional structural model for the asymmetric PhaCAp homodimer was constructed based on Chromobacterium sp. USM2 PhaC (PhaCCs). The obtained model of PhaCAp revealed that the overall fold of one monomer was in the closed, catalytically inactive conformation whereas the other monomer was in the catalytically active, open conformation. In the active conformation, the catalytic triad residues (Cys151-Asp310-His339) were involved in the binding of substrate 3HB-CoA and the CAP domain of PhaCAp involved in the dimerization.
Gallus évanescent dans l’Énéide : Irrévérence virgilienne ou transgression furtive d’un oubli imposé ?
Authors: Raymond-Dufouleur Emmanuelle 
Published: May 2023

This paper deals with the connected notions of memory and forgetting in the Aeneid.
It aims at showing how Vergil often displays a poetic oblivion that embraces augustan political practices about the art of forgetting : the poetic design of the Aeneid is shaped by political considerations over some famous figures as Marc Antony, Sextus Pompey or Julius Caesar whose memory were more or less embarrassing for the princeps. But despite the fact that Vergil is quite obedient to Augustus’ views in his handling of oblivion in his epic, one canwonder about the formula Gallumque rebellumwhich could be a discrete but nonetheless daring allusion to the bannished elegiac poet Cornelius Gallus.
Pouvoir de la métamorphose et métamorphose du pouvoir dans le Livre XIV des Métamorphoses d’Ovide
Authors: Delbey Évrard 
Published: May 2023

We think that it is not sufficient to say that the XIV Book of Ovid’s Metamorphoses
belongs to a whole (book XI to book XV) which is different from the anterior books because there are references to the war of Troy and to the history of Rome, culmination of metamorphoses. So we interpret the XIV Book as a different representation of the power : passage of the malevolent power of Circe to the power of the king Romulus whose apotheosis shows the positive aspects.
Symmaque dans le Contra Symmachum de Prudence : enjeux et significations d’une mise à mort littéraire
Authors: Herbert de la Portbarré Gaëlle 
Published: May 2023

In his Contra Symmachum, probably written in 404, Prudentius, a poet of triumphant Christianism, attacks an emblematic figure of Paganism, senator Symmachus,
famous for his skills as an orator. In the famous Relatio 3 written in 384 and addressed to Emperor Valentinian the 3rd, Symmachus protested against the withdrawal of the Victory’s altar from the Roman curia and the end of some privileges of the Pagan clergy, and especially the Vestals. The aim of this paper is to show that the literary «killing » of orator Symmachus and his speech is at the centre of the poem’s meaning. Prudentius obviously manipulates the figure of Symmachus, probably recently dead, to promote a radical Christianization of the Roman civilization in front of young emperor Honorius and his regent Stilicho. This view is very far from the one given a few months before by Claudian, the culturally Pagan poet of the court of Milan in his De bello Getico.
Le Fahs d’Alger : La redécouverte d’une organisation territoriale aujourd’hui disparue
Authors: Menouer Ouassila , Zerouala Mohamed salah 
Published: May 2023

Algiers, also known as El-Djezaïr city before 1830, used to develop a close relationship with its surrounding extra-urban territory. This represents for Algiers a relevant and necessary source of domestic products, building materials, the manufacturing, in addition to the various places for pleasure and leisure. By exploring the corresponding
archaeological remains, the main scope of this paper is to rediscover the natural-cultural landscape, which has been altered due to the large urbanisation process started since 1830.
La Conjuration de Catilina : une réflexion sur la crise de la République romaine
Authors: Salamon Gérard 
Published: May 2023

The paper aims to show that the subject of Sallust’s first monograph is not so much Catilina’s conjuration as the crisis of the Roman Republic, for which the conspiracy stands as an illustration. Indeed, nothing is settled nor solved by Catilina’s failure. Actually, Sallust attributes this crisis to the weakening of political uirtus amongst Roman leaders, which he defines as the ability to make the interests of the city prevail over one’s own. In the past, the city was strong enough to compensate for the shortcomings of those who governed it ; but at a time when the institutions themselves are collapsing, the risk is great for Rome to lose its supremacy. Distancing himself from any political discourse,
Sallust calls his contemporaries to save Rome.
Design and Analysis of Landing Gear using Composite Material
Authors: Fahaz Firoz  , Rupika Raj  , G. Diju Samuel  
Published: May 2023

Aircraft frames are supported physically by the system of assembly which is an important component of aircraft which helps in transferring the load bearded by the wing to the ground while landing this is known as landing gear therefore it is a vital part to construct a landing gear which could withstand external force and could show least deformation the experimental structural analysis conducted was to find the best alternate of titanium alloy mainly used for the manufacturing of triple bogey type of landing gear the structural analysis of landing gear which was designed in solid works has been analysed using the Ansys software from the obtained data we can understand least deformation shown by composite AL Sic.
Islamic Banking System: Need, Dimensions and Function
Authors: Basheer Dr. Aariefa 
Published: May 2023

The Islamic Banks can do the business without being involved in the forward swaps of the exchange dealings. When we move to borrowing and lending activities, the matters become different. Any extra repayment rather than the original principle in any lending-borrowing relation is considered to be usury. Usury in Islam isconsidered to be one of the big sins. In Islam, there is no difference between usury as an excessive interest or the so-called legal interest itself. Therefore depositors who in fact are a lender to the bank cannot be allowed to take interest in the Islamic measures; but he can be an investor. The percentage of profit must not be offered the same conditions applied to other investors by receiving a portion of the profit that comes out of the pool of the investment portfolio managed by the bank. The relation with the user of funds is not a borrowing-lending relation; but it has a different type of contractual arrangement. Therefore this paper examines the structure, function and dimensions of an Interest free Islamic bank.
A Study on the Trade Relationship between China & Mongolia: With Special Focus on Revealed Comparative Advantage (RCA)
Authors: Rashid Neelofar , Afzal Mir Mohammad 
Published: May 2023

Examining The Composition, Strength, Structure, Comparative Advantage, And Disadvantage Of Bilateral Commerce Between China And Mongolia From 2001 To 2020 Is The Main Goal Of This Article. The Normalised Revealed Comparative Advantage Index (Nrca) Is Used In The Study To Calculate The Composition And Structural Change Of Trade. Although The Nature Of The Trade Between The Two Nations Is Relatively Complementary, The Report Finds That The Potential For Trade Has Significantly Grown Over The Course Of The Study Period. Another Interesting Observation Is That China Imports A Significant Amount Of Goods From Mongolia, Which Has A Lot Of Mineral Resources. Due To China’s Preference For High-Tech Items And Comparative Advantage In Labor-Intensive Products, Technology Products Are Starting To Gain Popularity.The Majority Of China’s Exports To Mongolia Are Labor-Intensive, Low-Tech, And Low-Value Goods. To Meet The Demands Of Domestic Industry And Daily Living, Mongolia Imports These Labor-Intensive Goods, Enabling The Growth Of A Mutually Advantageous Partnership Between The Two Sides. In Addition, Only The Top 10 To 15 Commodities Accounts For The Majority Of China’s Overall Imports From Mongolia, And The Percentage Share Of Other Goods Has Remained Under 1% Throughout Time.
Examining Caste Consciousness in Kavita Kane’s Karna’s Wife and Fisher Queen’s Dynasty
Authors: Rathod Jasvant V 
Published: May 2023

Use of mythological tales for creating revisionist literature is contemporary approach of the modern Indian writers. Some famous works of literature, based on mythology are written by writers like Devdutt Pattanaik, Amish Tripathi, Chitra Banerjee Divakaruni, Volga, Kevin Missal, SarathKomarraju and Krishna Udayashankar. These writers try to reinterpret mythological characters like Shiva, Rama, Draupadi, Amba, Krishna etc. Kavita Kane is one of the popular woman writers of India who renders Indian mythological texts and writes novels. Her ficitons are known for portrayals of the mythical characters who are less discussed. She picks up marginalized women characters from the mythical literature of India and retells their stories. She raises isssues of identity, individuality, gender, caste, femininity and patriarchy in her fictional works. In her novels, Karna’s Wife and Fisher Queen’s Dynasty, Kane has woven issues of gender and caste. Both of them are based on the Mahabharata. She retells the stories of Uruvi, Karna’s wife and Satyavati, Shantanu’s wife from their perspectives and explore their struggles against discriminations based on gender and caste. The novelist depicts these women characters with their courage, confidence, individuality and power to resist the class or caste-based violence. As modern literary works, their intersectionality is evident and they can be examined keeping in mind multidisciplinary approach. The present article examines caste consciousness as expressed by Kane in her Karna’s Wife and Fisher Queen’s Dynasty.
Amitav Ghosh’s The Glass Palace and Orhan Pamuk’s My Name is Red: A Comparison
Authors: Keerthi Rajalakshmi V , Sankar K 
Published: May 2023

The paper aims to form a comprehensive and in-depth study of the theme of multiculturalism as portrayed within the selected novels of Orhan Pamuk and Amitav Ghosh. The reputed Indian novelist Amitav Ghosh has carved a distinct segment for himself within the world of fiction even as Orhan Pamuk who writes exquisite novels won the Nobel award. Pamuk’s work often touches on the deep rooted tensions of spiritual conflict between East and West, tradition and modernism or secularism. Loss of identity occurs in an alien land within the novel owing to the colonial impact within the postcolonial context. These are the ideas that involve relationship between individuals belonging to the identical or to different communities that sometimes transgress and transcend the shadow lines of political borders. Depicting meticulously the lives of Indian diaspora in Burma, this novel has taken a lot of time for Ghosh, travelling between the boundaries of south Asian countries as to incorporate the events of this novel. Ghosh tells the story of colonizer-colonized relationship through the temporal and spatial journeys of his characters. Pamuk and Ghosh talkabout the national identity, oppression, diaspora, exile and a host of such factors which influence the construction of a nation. Both as novelists deals with culture, nationality, tradition, the conflict between the east and the west, communication, defending individual’s rights of expression and belief and arguing against religious and nationalism.
Genealogy and Cultural Versatility in Amit Chaudhuri’s A New World
Authors: Aruna G , Punitha Jothi E.D 
Published: May 2023

The paper attempts to critically analyse the representation of cultural versatility about tradition, rituals, family, class and identities through the lens of Amit Chaudhuri’s novel A New World. By shedding light on culturally significant locations like Kolkata’s streets and markets as well as cultural components like cuisine and music in Bengali society, he hopes to study and re-examine the city’s past while portraying its present. The Indian immigrant Jayojit Chatterjee and his son Bonny’s hybridised sense of identity, dislocation, and alienation would be further discussed in Genealogy and Cultural Versatility. A New World does not substantively explore the struggle to conquer life in his new world. Instead, the novel is a celebration of the old world Jayojit has left behind.
Evaluation of growth and yield of cowpea (Vigna unguiculata L.Walp) cultivars and sorghum (Sorghum bicolor L. Moench) with their competitive behavior in cowpea-sorghum intercropping.
Authors: Afe A. I. , Nuruden K. , Yaman U. 
Published: May 2023

The need to increase cowpea production to solve the menace of malnutrition is a global challenge and land limitations have also made intercropping indispensable. Field trials were carried out at the Teaching and Research Farm, Kwara State University, Malete, and National Centre for Agricultural Mechanization (NCAM) Idofian to evaluate the growth and yield of cowpea cultivars and sorghum with their competitive behavior in cowpea-sorghum intercropping. Five cultivars of cowpea (IITA-256, IITA-277, VITAL-5, IT98K-491-4, and IITA-288) were intercropped with sorghum. Sole crops were included in the treatments as a check. The treatments were arranged in a Randomized Complete Block Design and replicated three times. Among the sole, vital-5 cultivar had the highest number of branches and pods per plant and more seeds per pod compared to other cultivars. The cultivar also recorded the highest grain yield 591.30 kg/ha and 530.00 kg/ha respectively, for Malete and NCAM at the sole. At the intercrop, IITA-288 significantly had the least number of branches per plant and took longer days to attain flowering compared to other cultivars. The lowest grain yield at the intercrop was also obtained with this cultivar. Sorghum intercropped with cowpea cultivar IITA-288 was at par with the sole sorghum in all the parameters. The least grain yield of sorghum at the intercrop was obtained in sorghum intercropping with IITA-256 cowpea cultivar. The maximum Land Equivalent Ratio (LER), and Land Equivalent Coefficient (LEC), was obtained with the Vital-5 cultivar. Regardless of location, the competitive ratio (CR) values for IITA-256, IITA-277, and Vital-5 cowpea cultivars were higher than sorghum. The aggressivisity, (A) for these cultivars were also positive for cowpea and negative for sorghum. Although, all the cowpea cultivars demonstrated intercropping advantages in efficient utilization of natural resources intercropping with the Vital-5 cowpea cultivar was superior and could be adopted by the farmer.
O acesso à educação infantil no estado de Mato Grosso–Brasil: ao final do Plano Nacional de Educação (2014-2024)
Authors: Cadidé Vilela Maria Cristiana da Silva , Queiroz de Morais Carlos Tadeu 
Published: May 2023

O estudo aqui apresentado tem como objetivo apresentar sobre o acesso à primeira etapa da Educação básica, Educação Infantil, de 0 a 5 anos no Estado de Mato Grosso, Brasil. A contribuição do estudo, se manifesta por entender sobre a importância do trabalho realizado no âmbito educacional por direito da criança. A infância é o período que se alicerça toda a estrutura de um indivíduo, em todas as dimensões. Oportunamente, a relevância do desenvolvimento desta pesquisa vem investigar sobre: como está o acesso à Educação Infantil no Estado de Mato Grosso, estando ao final do Plano Nacional de Educação? O método de pesquisa foi realizado através de pesquisa quantitativa, a partir do Censo escolar, Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP) e Instituto Brasileiro de Geografia e Estatística (IBGE) dos últimos anos (2010 a 2021). A análise ocorreu de natureza básica, a partir dos dados numéricos e estatísticos por meio de tabelas, gráficos e descrição dos dados.