bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Analysis of the Adoption of Conflict Resolution Model for Conflict Management in Colleges of Education and Universities in South-East Nigeria
Authors: Etele A. V. , Akunne L. I. 
Published: June 2023

Aims: This study compared the adoption of conflict resolution model for conflict management in colleges of education and universities in South-east Nigeria.
Study Design: The descriptive survey design was adopted for the study.
Place and Duration of Study: Academic staffs of Nwafor Orizu College of Education and Nnamdi Azikiwe University Awka, between November 2022 and February 2023.
Methodology: Simple random sampling technique of balloting with replacement was used to select 1,046 academic staffs from the accessible population of 5,225 academic staffs of Nwafor Orizu College of Education and Nnamdi Azikiwe University Awka. The standardized instruments adopted for data collection was conflict management style assessment by Reginald Akins. The psychometric properties of the instrument were validity and a reliability coefficient of 0.74; also the instrument was administered using the direct delivery approach. Data collected was analysed using arithmetic mean and standard deviation. A table of real limit of numbers was used to interpret the respondents’ response. Rarely - 1.00 - 1.49, Sometimes - 1.50 – 2.00, Often - 2.50 – 3.00, Always - 3.50 – 4.00. Analysis for this study was done using Statistical Package for Social Sciences (SPSS).
Results: The findings revealed that academic staffs in colleges of education always adopt competing mode of conflict resolution for conflict management. While, academic staffs in universities often adopt competing mode of conflict resolution for conflict management. Furthermore, academic staffs in colleges of education often adopt avoiding mode of conflict resolution for conflict management, while academic staffs in universities always adopt avoiding mode of conflict resolution for conflict management among others.
Conclusion: Conflict is inevitable in all organisations and the tertiary institutions being a formal organisation have intricate network of members with divergent needs that trigger conflicts. The findings of this study revealed that academic staffs in colleges of education and universities adopt conflict resolution model for conflict management.
Fertility Trends and Adverse Pregnancy Outcomes in Female Patients With Psoriasis in the UK
Authors: Chen Teng-Chou , Iskandar Ireny Y. K. , Parisi Rosa , Pierce Matthias , Tower Clare , Kleyn C. Elise , Griffiths Christopher E. M. , Ashcroft Darren M. ,   Global Psoriasis Atlas
Published: June 2023

ImportanceEvidence regarding fertility trends and obstetric outcomes among patients with psoriasis is limited by studies of small sample sizes, noninclusion of comparators, and the lack of accurate pregnancy records.ObjectiveTo investigate fertility rates and obstetric outcomes of pregnancies in female patients with psoriasis compared with age- and general practice–matched comparators without psoriasis.Design, Setting, and ParticipantsThis population-based cohort study used data from 887 primary care practices that contributed to the UK Clinical Practice Research Datalink GOLD database between 1998 and 2019, linked to a pregnancy register and Hospital Episode Statistics. There were 6 223 298 patients of common childbearing ages (15-44 years), and 63 681 patients with psoriasis had at least 1 year of follow-up data prior to the diagnosis of psoriasis. For each patient with psoriasis, 5 patients were matched by age from the same general practice. The median follow-up duration was 4.1 years. Data analysis was performed in 2021.ExposuresPatients with psoriasis were identified using clinical diagnostic codes from consultations.Main Outcomes and MeasuresFertility rates were calculated as the number of pregnancies per 100 patient-years. The outcomes of each pregnancy recorded in the pregnancy register or Hospital Episode Statistics were screened to identify obstetric outcomes. A negative binomial model was used to examine the association between psoriasis and the fertility rate. Logistic regression was applied to compare the association between psoriasis and obstetric outcomes.ResultsA total of 63 681 patients with psoriasis and 318 405 matched comparators were included in the analysis (median [IQR] age, 30 [22-37] years). Lower fertility rates (rate ratio, 0.75; 95% CI, 0.69-0.83) were found in patients with moderate to severe psoriasis. Compared with matched comparators without psoriasis, pregnancies in patients with psoriasis had a higher risk of loss (odds ratio, 1.06; 95% CI, 1.03-1.10); however, there was no increase in the risks of antenatal hemorrhage, preeclampsia, or gestational diabetes.Conclusion and RelevanceIn this cohort study, patients with moderate to severe psoriasis had a lower fertility rate, and the risk of pregnancy loss was higher than in matched comparators without psoriasis. Future research should identify the mechanism of increased risk of pregnancy loss among patients with psoriasis.
Cross-Sectional Analysis of Insurance Coverage for Lymphedema Treatments in the United States
Authors: Lynn Jeremy V. , Hespe Geoffrey E. , Akhter Maheen F. , David Christelle M. , Kung Theodore A. , Myers Paige L. 
Published: June 2023

ImportanceLymphedema is a debilitating condition that affects approximately 1 in 1000 individuals in the United States. Complete decongestive therapy is currently the standard of care, and innovative surgical techniques have demonstrated potential to further improve outcomes. Despite the growing armamentarium of treatment options, a large proportion of patients with lymphedema continue to struggle because of limited access to care.ObjectiveTo define the current state of insurance coverage for lymphedema treatments in the United States.Design, Setting, and ParticipantsA cross-sectional analysis of insurance reimbursement for lymphedema treatments in 2022 was designed. The top 3 insurance companies per state based on market share and enrollment data maintained by the Kaiser Family Foundation were included. Established medical policies were gathered from insurance company websites and phone interviews, and descriptive statistics were performed.Main Outcomes and MeasuresTreatments of interest included nonprogrammable pneumatic compression, programmable pneumatic compression, surgical debulking, and physiologic procedures. Primary outcomes included level of coverage and criteria for coverage.ResultsThis study included 67 health insurance companies representing 88.7% of the US market share. Most insurance companies offered coverage for nonprogrammable (n = 55, 82.1%) and programmable (n = 53, 79.1%) pneumatic compression. However, few insurance companies offered coverage for debulking (n = 13, 19.4%) or physiologic (n = 5, 7.5%) procedures. Geographically, the lowest rates of coverage were seen in the West, Southwest, and Southeast.Conclusions and RelevanceThis study suggests that in the United States, less than 12% of individuals with health insurance, and even fewer patients without health insurance, have access to pneumatic compression and surgical treatments for lymphedema. The stark inadequacy of insurance coverage must be addressed through research and lobbying efforts to mitigate health disparities and promote health equity among patients with lymphedema.
Long‐term safety and efficacy of stenting on correcting internal jugular vein and cerebral venous sinus stenosis
Authors: Bai Chaobo , Chen Zhiying , Ding Yuchuan , Ji Xunming , Yuan Junliang , Meng Ran 
Published: June 2023

AbstractObjectivesTo compare the long‐term safety and efficacy of stenting in correcting cerebral venous sinus stenosis (CVSS) and internal jugular venous stenosis (IJVS).MethodsPatients confirmed with CVSS or IJVS by imaging were enrolled in this real‐world study from 2014 through 2021. Clinical characteristics and long‐term outcomes of these two diseases entities post‐stenting were followed up and compared.ResultsThree hundred and nineteen patients were enrolled in this study, with a mean age of 48.83 years and a BMI of 25.08 on average. In which, 144 patients underwent stenting, the stenotic segments were corrected and the venous blood flow was restored immediately post‐stenting. At 6.15 ± 1.67 days follow‐up, significant improvement was observed in headache, tinnitus, insomnia, ICP, and mean pressure gradient in both groups (allp < 0.05). At 30.53 ± 4.41 months follow‐up post‐stenting, the headache, tinnitus, visual loss, papilledema, and insomnia were attenuated remarkably or even completely disappeared. The Frisen papilledema grade scores declined from 2 (0–4) to 1 (0–3) in IJVS group and from 4 (1–5) to 1 (0–4) in CVSS group compared to the baseline. One hundred and twenty‐seven out of the 144 patients (95.5%) maintained sufficient blood flow verified by followed up computed tomographic venography or contrast‐enhanced magnetic resonance angiography. Adverse events related to stenting included three cases of intraluminal restenosis and three cases of in‐stent thrombosis, no intracranial hemorrhage, venous thromboembolisms, stent‐adjacent stenosis, and stent displacement occurred.InterpretationUsing stents to correct IH and related neurological issues has shown to be a safe and effective approach for both IJVS and CVSS.
A multivariable super‐twisting‐based fault‐tolerant control with control allocation for uncertain systems
Authors: Ríos Héctor , Mera Manuel , Fridman Leonid 
Published: June 2023

SummaryThis article contributes with a fault‐tolerant control (FTC) for uncertain systems under the effect of some possible time‐ and state‐dependent actuator faults and/or failures, and component faults, which are zero at the initial time. The proposed scheme is based on a continuous integral sliding‐mode control approach and a fixed control allocation technique. The integral sliding‐mode control strategy allows us to design a robust linear controller and a multivariable Super‐Twisting algorithm, which deals with the faults. The proposed scheme guarantees the fulfilment of an output regulation task, with an arbitrarily small regulation error, and does not require a fault diagnosis stage but full‐state availability. The performance of the proposed FTC is illustrated through some simulations on a benchmark B747 aircraft model.
Bioinspired Multiantioxidant‐Cooperative Nanotheranostic Platform for Realizing Time‐Sensitive Management of Acute Kidney Injury
Authors: Wu Menglin , Lu Li , Li Jiang , Guo Qi , Wang Daohan , Gong Yan , Wu Xinhong , Zhao Xunxiao , Zhang Xuening , Zhao Yang , Li Xue 
Published: June 2023

AbstractTargeting the pivotal pathological processes of acute kidney injury (AKI) and parallelly monitoring the treatment process has emerged as an intriguing strategy for the timely tailored treatment of AKI, especially in the acute phase. Unfortunately, current clinical treatment approaches are restricted to supportive care, which shows limited efficiency. Herein, a multiantioxidant‐cooperative polydopamine‐based nanotheranostic platform (mc‐PDATP) is reported to achieve imaging‐assisted time‐sensitive therapy of AKI. Benefiting from the decoration of atomic Cu, mc‐PDATP comprehensively mimics the complicated antioxidant defense system as in natural environment, thus displaying improved catalytic activity to multiple toxic reactive oxygen species (ROS). Consequently, both in vitro and in vivo experiments confirm mc‐PDATP can efficiently protect the kidney from ROS attack and rescue the kidney function via targeting the inflammatory network of AKI. In addition, the coordinated atomic Gd contributes to a desired magnetic resonance (MR) T1‐weighted contrast effect of mc‐PDATP, which can be used to construct the sensitive MR histogram imaging signatures for pinpointing treatment effects in a timely manner. The study represents an innovative strategy for anti‐AKI therapy, which will facilitate the development of next‐generation theranostic nano‐antioxidants.
2D Ultrathin Iron Doped Bismuth Oxychloride Nanosheets with Rich Oxygen Vacancies for Enhanced Sonodynamic Therapy
Authors: Wu Miaomiao , Yong Jiaxi , Zhang Huayue , Wang Zhiliang , Xu Zhi Ping , Zhang Run 
Published: June 2023

AbstractSonodynamic therapy (SDT) combines ultrasound and sonosensitizers to produce toxic reactive oxygen species (ROS) for cancer cell killing. Due to the high penetration depth of ultrasound (US), SDT breaks the depth penetration barrier of conventional photodynamic therapy for the treatment of deeply seated tumors. A key point to enhance the therapeutic efficiency of SDT is the development of novel sonosensitizers with promoted ability for ROS production. Herein, ultrathin Fe‐doped bismuth oxychloride nanosheets with rich oxygen vacancies and bovine serum albumin coating on surface are designed as piezoelectric sonosensitizers (BOC‐Fe NSs) for enhanced SDT. The oxygen vacancies of BOC‐Fe NSs provide electron trapping sites to promote the separation of e−‐h+ from the band structure, which facilitates the ROS production under the ultrasonic waves. The piezoelectric BOC‐Fe NSs create a built‐in field and the bending bands, further accelerating the ROS generation with US irradiation. Furthermore, BOC‐Fe NSs can induce ROS generation by a Fenton reaction catalyzed by Fe ion with endogenous H2O2 in tumor tissues for chemodynamic therapy. The as‐prepared BOC‐Fe NSs efficiently inhibited breast cancer cell growth in both in vitro and in vivo tests. The successfully development of BOC‐Fe NSs provides a new nano‐sonosensitiser option for enhanced SDT for cancer therapy.
Supramolecular Photothermal Cascade Nano‐Reactor Enables Photothermal Effect, Cascade Reaction, and In Situ Hydrogelation for Biofilm‐Associated Tooth‐Extraction Wound Healing
Authors: Chen Lei , Peng Mengna , Zhou Jianan , Hu Xiaowen , Piao Yinzi , Li Huaping , Hu Rongdang , Li Yuanfeng , Shi Linqi , Liu Yong 
Published: June 2023

AbstractDue to the emergence of drug resistance in bacteria and biofilm protection, achieving a satisfactory therapeutic effect for bacteria‐infected open wounds with conventional measures is problematic. Here, a photothermal cascade nano‐reactor (CPNC@GOx‐Fe2+) is constructed through a supramolecular strategy through hydrogen bonding and coordination interactions between chitosan‐modified palladium nano‐cube (CPNC), glucose oxidase (GOx), and ferrous iron (Fe2+). CPNC@GOx‐Fe2+ exhibits excellent photothermal effects and powers the GOx‐assisted cascade reaction to generate hydroxyl radicals, enabling photothermal and chemodynamic combination therapy against bacteria and biofilms. Further proteomics, metabolomics, and all‐atom simulation results indicate that the damage of the hydroxyl radical to the function and structure of the cell membrane and the thermal effect enhance the fluidity and inhomogeneity of the bacterial cell membrane, resulting in the synergistic antibacterial effect. In the biofilm‐associated tooth extraction wound model, the hydroxyl radical generated from the cascade reaction process can initiate the radical polymerization process to form a hydrogel in situ for wound protection. In vivo experiments confirm that synergistic antibacterial and wound protection can accelerate the healing of infected tooth‐extraction wounds without affecting the oral commensal microbiota. This study provides a way to propose a multifunctional supramolecular system for the treatment of open wound infection.
Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy
Authors: Liang Guanghao , Wang Linchen , You Qiancheng , Cahill Kirk , Chen Chuanyuan , Zhang Wei , Fulton Noreen , Stock Wendy , Odenike Olatoyosi , He Chuan , Han Dali 
Published: June 2023

AbstractAzacitidine (AZA) is a DNA methyltransferase inhibitor and epigenetic modulator that can be an effective agent in combination with chemotherapy for patients with high‐risk acute myeloid leukemia (AML). However, biological factors driving the therapeutic response of such hypomethylating agent (HMA)‐based therapies remain unknown. Herein, the transcriptome and/or genome‐wide 5‐hydroxymethylcytosine (5hmC) is characterized for 41 patients with high‐risk AML from a phase 1 clinical trial treated with AZA epigenetic priming followed by high‐dose cytarabine and mitoxantrone (AZA‐HiDAC‐Mito). Digital cytometry reveals that responders have elevated Granulocyte‐macrophage‐progenitor‐like (GMP‐like) malignant cells displaying an active cell cycle program. Moreover, the enrichment of natural killer (NK) cells predicts a favorable outcome in patients receiving AZA‐HiDAC‐Mito therapy or other AZA‐based therapies. Comparing 5hmC profiles before and after five‐day treatment of AZA shows that AZA exposure induces dose‐dependent 5hmC changes, in which the magnitude correlates with overall survival (p= 0.015). An extreme gradient boosting (XGBoost) machine learning model is developed to predict the treatment response based on 5hmC levels of 11 genes, achieving an area under the curve (AUC) of 0.860. These results suggest that cellular composition markedly impacts the treatment response, and showcase the prospect of 5hmC signatures in predicting the outcomes of HMA‐based therapies in AML.
Climate change and managing insect pests and beneficials in agricultural systems
Authors: Eigenbrode Sanford D. , Adhikari Subodh 
Published: June 2023

AbstractClimate change is expected to alter pressure from insect pests and the effectiveness of insect pollinators across diverse agricultural systems globally. In response to warming, insects are undergoing or are projected to undergo shifts in their geographic ranges, voltinism, abundance, and phenology. Effects on the focal insect species can be affected directly or indirectly, through their interactions with other species at higher and lower trophic levels. These climate‐driven effects are complex and as a result variable, sometimes increasing pest pressure or reducing pollination and sometimes with opposite effects depending on climatic baseline conditions and the interplay of contributing drivers. This uncertainty prevents effective responses. Furthermore, in addition to effects of climate change on insect pests and pollinators, projected and ongoing climate change is incentivizing changes in cropping systems such as altered tillage and increasing diversification and intensification with the potential to alter pests and pollinators as great as climate itself. Preparing for this uncertainty must be included in a framework for “Climate‐smart Integrated Pest and Pollinator Management,” as a component of agricultural production under climate change.
Impact of guar gum‐based hydrogel on yield and economics for sugarcane crops
Authors: Songara Jaysukh C. , Patel Jayantilal N. 
Published: June 2023

AbstractAccording to the current scenario, water crises are booming at a higher rate globally, affecting different demands such as agricultural, domestic, industrial, and so forth. Ultimately, such a water crisis may affect food safety. We have developed guar gum (GG)‐based hydrogel to help solve this issue with a water‐saving objective. This paper presents the application performance of newly developed GG‐based hydrogel on sugarcane crop growth, yield, and its economics. The crop water requirement and irrigation scheduling are also obtained using the CROPWAT model. Comparing different irrigation practices indicates that six irrigations can be saved by applying the CROPWAT optimization model, and up to three irrigations can be saved by applying different dosages of GG‐based hydrogel against the conventional method. Moreover, a set dosage application of 2.5 and 5 kg ha−1 of GG‐based hydrogel has elevated the cane height up to 8.67% and 10.02%, respectively. Furthermore, a considerable increment of 5.5% and 8% was found in the crop yield. In addition, the average soil moisture was found to be 10.50% and 17% higher over the field without hydrogel by using an indigenously developed Internet of Things–based SS316L soil moisture sensor. Applying GG‐based hydrogel (2.5 and 5 kg ha−1) saves the number of irrigations by two and three times, respectively. When it comes to the economy, the benefit–cost ratio for 2.5 and 5 kg ha−1 hydrogel dosages was found to be 2.64 and 2.09, respectively. Thus, GG‐based hydrogel shows substantial promise as a useful agricultural product for water‐saving purposes.
Combine effects of inorganic and organic nutrient sources on maize–sesame cropping sequence of middle Gujarat
Authors: Chauhan Zalak Y. , Shah Sanjay N. , Patel Hiren K. 
Published: June 2023

AbstractIncreasing uses of nutrients have played a major role in increasing the food supply to a continually growing world population. However, excessive use of chemical fertilizers results in significant losses, inefficient utilization, and nutritional imbalance. However, poor soil management, inadequate nutrient application, and extreme weather conditions have all contributed to soil degradation. Prudent usage of integrated nutrient management (INM) is the greatest alternative to provide nutrients to crop needs and enhance soil conditions to repair the soil's nutrient depletion. To examine the impact of INM on the yield of rabi maize (Zea mays L.) and its lasting effects on succeeding summer sesame (Sesamum indicum L.) under irrigated conditions during 2019–2020 to 2021–2022 at College Agronomy Farm, Bansilal Amrutlal (B. A.) College of Agriculture, Anand Agricultural University, Anand, Gujarat, India, a field trial was conducted on loamy sand soil of Agro‐Climatic Zone–XIII, Gujarat Plains, and Hills region, India. The experiment was laid out in randomized block design with 3 replications and 12 treatments. The improved growth, yield, and protein content of the maize crop were obtained by the application of 75% recommended dose of fertilizer (RDF) + 25% recommended dose of nutrient (RDN) through vermicompost + nitrogen–phosporus–potassium (NPK) consortium (soil application). In the subsequent sesame crop, residual effects of 75% RDF + 25% RDN through farm yard manure (FYM) + NPK consortium (soil application) together with 50% RDF (50:25:00 NPK kg/ha) were reported, which led to higher crop growth and yield. Under the conditions of middle Gujarat, the application of 75% RDF + 25% RDN through the FYM + NPK consortium (soil application) led to a greater system net realization in the maize–sesame sequence.