bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Crucial Role of Awareness and Education in Promoting Effective Diabetes Self-Management and Reducing the Risk of Complications
Authors: AKAY ÇİZMECİOGLU Hilal , GÖKTEPE Mevlüt Hakan , CİZMECİOGLU Ahmet 
Published: September 2023

Objective: Disease awareness is a pivotal factor in the management of illness. In chronic and progressive conditions, such as diabetes mellitus (DM), this awareness can be as effective as pharmacological interventions. This study aimed to assess how aware diabetic patients are of the complications of their disease.
Method: This cross-sectional survey included patients diagnosed with DM. A total of 14 survey questions, divided into 7 different categories, were directed at the patients. The singular questions evaluated the patients' awareness of the complications, while the associated-secondary questions aimed to inquire about the sources of their awareness.
Result: In this study, a survey was conducted with 300 diabetic patients, yielding a response rate of 90.2%. The mean age was 53 years. The level of awareness of complications was high among all patients (80.5%). The awareness level of ocular-related complications was the highest, while that of neuropathy was the lowest (50%). When patients were categorized by educational status, education increased awareness but decreased adherence to combined drug use. The patients' doctors were identified as the most significant source of support for raising awareness of complications. This support was further enhanced by the educational level.
Conclusion: High levels of awareness of complications related to diabetes, still being primarily provided by doctors, and improvement of patients' educational status, can lead to a decrease in the number of patients with a poor prognosis. Therefore, increasing awareness of diabetes-related complications and improving patients' educational status may positively impact reducing the incidence of poor prognosis among diabetes patients.
The efficacy of recombinant feline interferon-omega in treating symptomatic cats infected with feline immunodeficiency virus
Authors: Garrett Rachel 
Published: September 2023

PICO Question
In symptomatic cats with feline immunodeficiency virus (FIV), does high-dose subcutaneous recombinant feline interferon-omega (rFeIFN-ω) administration lead to reduced clinical signs compared to cats who were not administered rFeIFN-ω?

Clinical bottom line
Category of research
Treatment.

Number and type of study designs reviewed
Three studies were critically reviewed, including one randomised controlled trial, one non-randomised controlled trial, and one uncontrolled clinical trial.

Strength of evidence
Weak.

Outcomes reported
Each of the studies reported that rFeIFN-ω administration significantly reduced clinical signs in FIV infected cats. However, all three papers have limitations in their study design and statistical analysis which lower the strength of the evidence they provide.

Conclusion
There is only weak evidence demonstrating that rFeIFN-ω administration leads to reduced clinical signs in FIV positive cats. Currently, there is a lack of well-designed, double-blinded, randomised, placebo-controlled clinical trials which have an adequate sample size and specifically focus on FIV positive cats. As a result, more robust evidence is needed to prove the definitive therapeutic benefit of rFeIFN-ω in symptomatic FIV patients. Treatment with rFeIFN-ω may still be considered by clinicians for cats with clinical signs potentially associated with retroviral infection, such as oral lesions and stomatitis, particularly if they are not responding well to supportive therapy alone.

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
THE INFLUENCE OF EDUCATION, HEALTH, POVERTY, AND UNEMPLOYMENT ON ECONOMIC GROWTH THROUGH THE HDI IN SOUTH SUMATERA 2017-2021
Authors: Hidayat Randy , Sahri Yulian 
Published: September 2023

Abstract
Southern Sumatra consists of the provinces of South Sumatra, Lampung, Jambi, Bengkulu, and the Bangka-Belitung Islands. These five provinces have the fastest recovering economic growth compared to other regions in Indonesia and the highest economic growth recovery in Sumatra from 2020-2021. Therefore, this study aims to analyze what factors influence economic growth in 60 cities/districts in Southern Sumatra.

Key Words: Factors, Economic Growth, Southern Sumatra
STRATEGI PENGUMPULAN ZAKAT MAL DI BAZNAS KOTA LUBUK LINGGAU DI TINJAU DARI HUKUM EKONOMI SYARIAH
Authors: Kusmawaningsih Susi , Aryanti Gita 
Published: September 2023

Pengumpulan zakat sebagai upaya yang digunakan untuk menjaga keuangan lembaga agar tetap stabil dan berkembang. Badan amil zakat harus memiliki strategi yang sesuai dengan kondisi dan situasi masyarakat agar mampu memaksimalkan fungsi lembaga dan memberikan manfaat guna mengurangi kemiskinan dan kesenjangan sosial. Tujuan penelitian ini adalah Strategi yang dilakukan dalam meningkatkan pendapatan dana ZIS demi menjaga kestabilan keuangan dan Pengelolaan Zakat di BAZNAS Kota Lubuklinggau yang saat ini belum sesuai dengan apa yang diharapkan Tentang Pengelolaan Zakat, Infak dan Sedekah. Dalam strategi ini BAZNAS melakukan sosialisasi dan silaturahmi, kepada yang dikenakan zakat, infaq dan shadaqah dengan berbagai macam cara diantaranya menyurati muzakki dan silaturahim. Program-program yang dilakukan Baznas dengan cara mengadakan gerakan bulan sadar zakat, infaq dan sedekah. Memberikan penjelasan dan motivasi zakat, infaq dan sedekah dalam bentuk ceramah, tabligh akbar, melakukan gerakan seminar dan dialog bersama pemerintah daerah, ulama dan zu’ama di semua tingkat, dengan mengadakan kerja sama dengan setiap dinas, badan dan instansi yang ada dan Baznas tidak berhenti-hentinya untuk selalu sosialisasi agar orang yang sudah wajib bayar zakat akan mengeluarkan zakatnya dan masyarakat-masyarakat yang belum mengerti dan belum tau. Jenis penelitian ini adalah kualitatif yakni menggunakan teknik observasi, wawancara dan dokumentasi. Kemudian Teknik analisis data yaitu menggunakan pola pikir induktif yang berpijak pada fakta-fakta yang bersifat khusus kemudian diteliti, dianalisis dan disimpulkan sehingga memecahkan persoalan dan berlaku secara umum.

Kata kunci : Strategi, Zakat, Baznas
Hasil Validasi CATUR STEM: Buku Panduan bagi Guru Kimia untuk Menyusun RPP Berbasis STEM
Authors: Isnaini Muhammad , Farwati Ratna , Metafisika Kartika 
Published: September 2023

There are not many detailed explanations on how to design STEM learning in chemistry lesson scope. This has made researchers and chemistry teachers not understand about its application in the classroom. Therefore, this study aims to develop a guidebook containing theories on how to design STEM learning. This research used Design and Development Research with these stages being carried out, namely (1) analysis of STEM concepts and lesson plans, (2) design of the CATUR STEM outline, (3) development of the contents of the CATUR STEM guidebook, and (4) assessment which includes validation of guidebook content. This guidebook has been declared very valid without revision by 12 validators involved with a validity value of 3.74 (out of a maximum score of 4.00). This guidebook contains information about STEM learning using modification of Engineering Design Process (EDP), how to create lesson plans based on Merdeka Belajar policy and STEM-EDP learning, and a collection of examples of STEM-EDP learning lesson plans. It is highly expected that this guidebook will later be tested to teachers of early childhood education programs, elementary schools, junior high school as an attempt to strengthen the theory of the STEM learning model.
2012-2023 Yılları Arasında Müzik Eğitiminde Yapılmış Çalışmaların Araştırma Eğilimlerine İlişkin Bibliyometrik Bir İnceleme
Authors: LEHİMLER Eren 
Published: September 2023

Mevcut eğitim sistemi içerisinde yaşanan gelişmeler ve değişimler söz konusu olduğunda çoğunlukla yapılan çalışmaların süreç içerisinde en çok paya sahip olduğu bilinmektedir. Müzik eğitimi sistemi içerisinde de yenilikçi yaklaşımlar ve doğru öğretim tekniklerini destekleyen bilimsel çalışmaların eğitim sürecinde rehber olarak yer edindiği söylenebilir. Bu doğrultuda, müzik eğitimi alanında yapılmış olan çalışmaların genel olarak sistemsel bir şekilde ortaya konulması gerektiği düşüldüğünden bu araştırma yapılmıştır. Araştırmada, müzik eğitimi alanında yapılmış çalışmaların çeşitli değişkenler üzerinden eğilimlerini ortaya koymak amacı güdülmüştür. Bu amaç doğrultusunda çalışmada bibliyometrik analiz yöntemi kullanılmıştır.
Araştırmada kullanılan veriler Web of Science (WOS) veri tabanı kullanılarak elde edilmiştir. Çalışmada, elde edilen veriler çeşitli değişkenlere göre filtrelenerek 3080 bilimsel çalışmaya ulaşılmıştır. Araştırmada, bilimsel çalışmaların yıllara göre dağılımları, ülkelerin üretkenliği, yazarların başka ülkelerde bulunan yazarlarla iş birliği yapma düzeyleri, yayın yapılan dergilerin etki değerleri, alan yazarlarının etki değerleri, çalışmaların tematik analizleri ve çalışmalarda kullanılan anahtar kelimelerin sıklıkları ortaya konulmuştur.
Sonuç olarak müzik eğitimi alanında, 2017 yılında en yüksek çalışma sayına ulaşıldığı, Amerika Birleşik Devletleri’nin en üretken ülke olduğu, yapılan çalışmalara oranla en çok iş birliğinin Finlandiya’da yapılan çalışmalarda olduğu sonuçlarına ulaşılmıştır. En çok yayın yapılan derginin “International Journal of Music Education” olduğu, alıntılanma düzeyinde en etkin derginin “Journal of Research in Music Education” olduğu belirlenmiştir. Hallam ve Creech isimli yazarların en fazla etki değerine sahip oldukları gözlemlenmiştir. Son yıllarda en çok kullanılan kelime ve başlıkların “müzik öğretmeni”, “müzik eğitimi” ve “informal müzik eğitimi” başlıklarında “yetenek”, “performans” ve “müzikal gelişim” olduğu sonucuna ulaşılmıştır.
ANALISIS MINAT BEKERJA DAN STUDI LANJUT SISWA SMK DI KOTA SURAKARTA DITINJAU DARI AKADEMIK DAN EKONOMI
Authors: Hapsari Zaena , , Suharno Suharno , , Ranto Ranto , 
Published: September 2023

<p class="abstrak"><em>The purpose of this research is to : 1) influence academic and economy to interest enter world industri SMK students throughout Surakarta and influence academic and economist to interest studies carry on SMK students in Surakarta. Method research used in study this that is with method study quantitative descriptive . Population used by 452 students with taking sampel by Simple Random Sampel as many as 213 students . The data collected used questionnaire questionnaire . Technique analysis used that is technique analysis multiple linear regression . Results study show that : 1) there is significant influence between academic variabels to interest enter industrial world with sig value 0.023 &lt; 0.05. 2) there significant influence between economic variabels to interest enter industrial world with sig value 0.00&lt;0.05. 3) there significant influence between academic variabels to interest studies carry on with score significance 0.046 &lt; 0.05. 4) no there is significant influence between economic variabels to interest studies carry on with score significance 0.174 &gt; 0.05.</em></p>
Electron Transport and Optical Properties of Pyrene derivatives for OLED Applications: A DFT Approach
Authors: Felscia U.Reeta , Rajkumar Beulah J.M , Mary M.Briget 
Published: September 2023

Abstract
The charge transport properties of aminopyrene (APy) and pyrene acetic acid (PAA) are investigated using the B3LYP/6-31++G(d,p) level of theory. The charge distributions of the systems are analyzed using the natural population analysis (NPA) and the plot of molecular electrostatic potential (MEP). Reorganization energy calculation is carried out to identify the charge transport behavior of the molecules under study. The energy level diagram and electrophilicity index identifies APy as the better system and its mobility computations are also performed. The energy level alignment, fluorescence behavior and mobility of charges suggest the application of APy in the design of electron transport layer (ETL) in blue OLED devices.
APCDD1 outperforms other dopaminergic cell surface markers in benchmarking study
Authors: Kirkeby Agnete , Schörling Alrik , Hänninen Erno , Rifes Pedro , Salvador Alison , Holm Amalie , Rathore Gaurav Singh , Nelander Jenny , Christiansen Josefine , Jensen Simone Møller , Niclis Jonathan , Gustafsson Emma , Aldrin-Kirk Patrick , Zhang Yu , Parmar Malin 
Published: September 2023

Abstract
Cell surface markers are useful tools for quality control and enrichment of cellular subtypes, such as the dopaminergic progenitors used in the treatment of Parkinson’s disease (PD). Here, we identified a candidate dopaminergic (DA) progenitor surface marker, APCDD1, and benchmarked its specificity against 7 other previously published markers. APCDD1 correlated with key markers of ventral midbrain DA fate and outperformed the 7 other markers in specificity. Antibody-based sorting for APCDD1 enabled enrichment of DA progenitors and depletion of neighbouring non-DA populations. When sorting from mixed cell populations, only APCDD1+ cells, and not APCDD1- cells, yielded full motoric amelioration after grafting in a rat model of PD, and the APCDD1+ grafts contained a higher proportion of DA neurons co-expressing ventral midbrain markers FOXA2 and LMX1A. Taken together, APCDD1 outperformed previously published surface markers and will be useful for improving the quality control and enrichment of clinically applied cell products for PD.
Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway
Authors: Jiang Yuwei , Park Jooman , Hu Ruoci , Xiong Shaolei , Qian Yanyu , Sabbagh Asma El , Ibrahim Meram , Song Qing , Yan Gege , Song Zhenyuan , Mahmoud Abeer , He Yanlin , Layden Brian , Chen Jiwang , Ong Sang-Ging , Xu Pingwen 
Published: September 2023

Abstract

Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages they offer are compromised with aging. Here, we show that treating mice with estrogen (E2), a hormone that decreases with age, to mice can counteract the aging-related decline in beige adipocyte formation when subjected to cold, while concurrently enhancing energy expenditure and improving glucose tolerance. Mechanistically, we find that nicotinamide phosphoribosyltranferase (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related ER stress. Furthermore, we found that targeting NAMPT signaling, either genetically or pharmacologically, can restore the formation of beige adipocytes by increasing the number of perivascular adipocyte progenitor cells. Conversely, the absence of NAMPT signaling prevents this process. In conclusion, our findings shed light on the mechanisms governing the age-dependent impairment of beige adipocyte formation and underscore the E2-NAMPT controlled ER stress as a key regulator of this process.
TRAPP-TRanexamic Acid for the prevention of Postpartum hemorrhage in pregnant women with placenta Previa: a multicenter randomized, double-blind, placebo-controlled trial
Authors: Zhang Lizi , Hu Miao , Bi Shilei , Poon Liona C , He Fang , Li Hongtian , Wang Zhijian , Du Lili , Chen Dunjin 
Published: September 2023

Abstract

Background
The prophylactic use of tranexamic acid (TXA) has been shown to reduce blood loss in low-risk populations during cesarean deliveries. However, the effectiveness of TXA in reducing postpartum hemorrhage (PPH) in high-risk populations remains uncertain due to a lack of high-quality evidence. Therefore, conducting multicenter randomized controlled trials with sufficient statistical power is crucial to establish the persuasive value of TXA before its widespread use for PPH prevention pregnant women with placenta previa.
Methods/Design:This study will be a multicenter randomized, double-blind, placeto-controlled trial with two parallel groups, including 1680 patients undergoing cesarean delivery with placenta previa. Participants will be randomly assigned to receive either tranexamic acid (1 g) or placebo intravenously immediately after birth. The primary outcome will be the incidence of PPH, defined as a calculated estimated blood loss exceeding 1000 mL or the need for red blood cell transfusion before postpartum day 2. With 80% statistical power, this study aims to demonstrate a 20% reduction in the incidence of PPH, from 33.0 to 26.4%.
Discussion: Tranexamic acid is a cost-effective and easily accessible medication that shows promise in reducing the risk of PPH during cesarean delivery in high-risk patients, such as those with placenta previa. This large-scale, adequately powered, multicenter randomized placebo-controlled trial aims to determine whether the benefits of routine prophylactic use of tranexamic acid during cesarean delivery in patients with placenta previa outweigh its associated risks.
Trial registration: ClinicalTrials.gov NCT05811676 (March 15, 2023).
Number Needed to Vaccinate to prevent one death: a propensity score matching approach to COVID-19 vaccine evaluation in the center of Iran (short communication)
Authors: Mandegari Zahra , Soodejani Moslem Taheri 
Published: September 2023

Abstract
Background
The Number Needed to Vaccinate is a measure of vaccine usefulness that enables policymakers to raise public awareness concerning the advantages of vaccination and make public health decisions. Therefore, we aimed to estimate the NNV to prevent one death from the Covid-19 disease.
Methods
This hospital-based case-control study utilized the data of a regional COVID-19 registry in Yazd, Iran. The study population comprised all patients diagnosed with COVID-19 who had been referred to the public and private medical centers of Yazd City from March 2018 to September 19, 2021. The individuals with a positive RT-PCR test who died from the COVID-19 disease were assigned as cases, and whom they survived were controls. A propensity-score matching method was performed to correct the effect of clinically significant confounders with a case-control ratio of 1:1. The statistical analyses were performed using Stata/MP V.16.
Results
A total number of 12,211 participants were included in this study, of whom 522 (%4.27) and 11,689 (%95.73) individuals were cases and controls, respectively. The respective NNVs in 50-59-year-old and 60-year-old and higher individuals were approximately 36 and 28 (P < 0.01).
Conclusions
The older patients had lower and more favorable NNVs compared to younger individuals. This finding could introduce a prioritized group of preventive measures in future outbreaks of the COVID-19 disease and/or booster vaccinations.
Association of sinusitis with systemic and local adipose tissue in adults: a cross-sectional study
Authors: Cao Qing , Han Miaomiao , Cao Yujie , Guan Bing , Meng Chanfang , Li Huabin 
Published: September 2023

Abstract
Background Obesity is associated with several nasal diseases. However, as indicated by conflicting findings from multifarious studies, the association of sinusitis with systemic and local adipose tissue remains inconclusive.
Methods In this cross-sectional study, we examined the relationship between sinusitis and adipose tissue in adults using data from 3,203 participants in the 2005-2006 National Health and Nutrition Examination Survey through multivariate logistic regression models. Three indicators were utilized to assess this association: a systemic indicator of Body Mass Index (BMI), as well as two local indicators of Waist Circumference (WC) and Head Percent Fat (HPF).
Results Compared to individuals with normal weight or those overweight, only those classified as obese were exposed to increased odds of sinusitis in adults (adjusted odds ratio, 1.77; 95% CI, 1.12-2.81) in this study focusing on systemic adipose tissue. Additionally, central obesity was found to be associated with elevated odds of sinusitis in adults (adjusted odds ratio, 1.57; 95% CI, 1.09-2.21) in this study emphasizing on local adipose tissue. Further analysis stratified by sex revealed that the observed association of central obesity were attenuated and became statistically insignificant among male adults while remaining significant among female adults (adjusted odds ratio, 1.69; 95% CI, 1.05-2.73). Meanwhile, WC, an indicator of abdominal fat as a continuous variable, showed a statistically significant association with sinusitis only in female adults during a sex-stratified analysis (adjusted odds ratio, 1.02; 95% CI, 1.01-1.03). Another continuous local adipose variable HPF was found to have a significant association with sinusitis in both males (adjusted odds ratio, 1.53; 95% CI, 1.22-1.91) and females (adjusted odds ratio, 1.3; 95% CI, 1.08-1.56). The optimal cutoff values for BMI and WC indicating sinusitis were determined to be 34.97 kg/m2 and 103.4 cm, respectively.
Conclusions This study demonstrates that both systemic and local adipose tissue are associated with an increased risk of sinusitis in adults, especially among females. Further investigations are needed to elucidate the underlying mechanisms and explore the potential benefits of weight management for preventing and treating sinusitis.
A new insight into the pathway behind spontaneous recurrent pregnancy loss: decreased CYR61 gene expression
Authors: Fıratlıgil Fahri Burçin , Firatligil-Yildirir Burcu , Yalcin-Ozuysal Ozden 
Published: September 2023

Abstract
Purpose: To investigate the potential role of CYR61 in recurrent pregnancy loss (RPL) is critical for developing diagnostic approaches and treatments for RPL.
Methods: In this prospective case–control study, we have investigated the expression patterns of CYR61 in blood samples from participants with RPL in their medical history and control group (n= 20 vs n=10). Peripheral blood mononuclear cells from study and control groups were isolated and the expression patterns of CYR61 gene were determined by RT-qPCR.
Results:It was demonstrated a significant decrease in CYR61 gene expression in patients with two or more clinically recognized miscarriages compared to patients without miscarriages or with a history of miscarriage (p < 0.01), which may make the CYR61 gene a potential candidate for predicting the risk of RPL.
Discussion:This study provides a basis for a detailed investigation of candidate biomarkers and molecular players involved in the development of RPL and for the development of potential treatment approaches to prevent RPL.