bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circle of success—An interpretative phenomenological analysis of how Black engineering students experience success
Authors: Henderson Jerrod A. , Junqueira Waldemiro , Benjamin Le Shorn S. , Hines Erik M. , Alarcón Jeannette D. , Davis Jared L. , Cavazos Sebastian 
Published: March 2023

AbstractBackgroundThough minoritized undergraduate engineering students earn less than 25% of engineering bachelor's degrees, minority‐serving institutions (MSIs) are leading the way in producing a large percentage of those underrepresented engineering bachelor's degree holders. However, much of the published research about the experiences of underrepresented engineering students occurs within the context of predominantly White institutions. Upon deeper inspection into the apparent success of some MSIs, graduation rates of specific minoritized populations (e.g., Black students) remain critically low. This suggests that there is more to be learned about how to better support Black engineering students' success.PurposeWe explored the experiences of Black undergraduate engineering students at a large public doctoral university with very high research activity.Design/MethodWe used interpretative phenomenological analysis to understand the experiences of eight participants.FindingsWe inductively developed two themes to describe how Black engineering students experience success at a Hispanic‐serving institution, which include building success networks and implementing rules of engagement.ConclusionParticipants enacted their cultural capital to construct their circles of success through the intentional engagement of others, resources, and themselves to realize success. This work sheds light on how Black students describe what it means to be successful in their engineering environment.
Variability of definition of high‐risk multiple myeloma across phase III clinical trials
Authors: Abu Za'nouneh Faris Jamal , Ababneh Obada , Schinke Carolina , Thanendrarajan Sharmilan , Zangari Maurizio , Shaughnessy John D. , Zhan Fenghuang , van Rhee Frits , Al Hadidi Samer 
Published: March 2023

AbstractThe definition of high‐risk multiple myeloma (HRMM) is evolving. Use of a clear definition of HRMM in clinical trials was not previously studied. We explored the definition of HRMM in completed phase III clinical trials. There is extreme variability in the definition and cutoffs used to define HRMM, with a significant number of studies lacking a clear definition. Our study provides a quantification of the variability in defining HRMM and suggests a need to better define HRMM in future clinical trials to enable more consistent treatment recommendations.
Gastrointestinal Symptoms of Monkeypox Infection: A systematic review and meta‐analysis
Authors: Simadibrata Daniel Martin , Lesmana Elvira , Pratama Muhammad Iqbal Adi , Annisa Nagita Gianty , Thenedi Kevin , Simadibrata Marcellus 
Published: March 2023

AbstractSince early May 2022, outbreaks of Monkeypox (Mpox) cases have emerged and become a global concern. Studies exploring the gastrointestinal symptoms and/or liver injury of Mpox are still very limited. This systematic review and meta‐analysis is the first to summarize the gastrointestinal symptoms reported by Mpox patients. We searched for Mpox studies published until October 21, 2022, in MEDLINE, EMBASE, SCOPUS, and organization websites. Mpox studies were observational studies that reported at least one of either gastrointestinal symptoms and/or liver injury in Mpox patients. Meta‐analysis was done to obtain the pooled prevalence of gastrointestinal symptoms in Mpox patients. Subgroup analyses were done based on the study location, age groups, and Mpox Clades. The quality of included studies was assessed using the NIH Quality Assessment Tool. Overall, 31 studies that reported gastrointestinal symptoms and/or liver injury in Mpox patients were included. The reported gastrointestinal symptoms were abdominal pain, anorexia, diarrhea, nausea, and vomiting. There is a lack of reporting for liver injury. The most prevalent gastrointestinal symptoms in Mpox patients were anorexia (47%; 95% confidence interval [CI] 41%–53%), followed by vomiting (12%; 95% CI 11%–13%), nausea (10%; 95% CI 9%–11%), abdominal pain (9%; 95% CI 8%–10%), and diarrhea (5%; 95% CI 4%–6%). Additionally, the prevalence of proctitis, rectal/anal pain, and rectal bleeding were 11% (95% CI 11%–12%), 25% (95% CI 24%–27%), and 12% (95% CI 11%–13%), respectively. Anorexia was the most frequently reported gastrointestinal symptom in Mpox patients, followed by vomiting, nausea, abdominal pain, and diarrhea. Proctitis is a novel presentation of Mpox in the 2022 outbreak.
Immune checkpoint inhibitor‐mediated psoriasis treated with biologics
Authors: Yeo Pei Ming , Chandran Nisha Suyien 
Published: March 2023

AbstractSkin toxicities are the most prevalent immune‐related adverse events of immune checkpoint inhibitors (ICIs), but psoriasis is uncommon. To date, there are no treatment guidelines for this unique patient cohort. We describe a case of ICI‐mediated psoriasis and its treatment using a tumour necrosis factor‐α blocker. A 61‐year‐old Chinese female with stage IV intrahepatic cholangiocarcinoma experienced significant worsening of her chronic plaque psoriasis and nail psoriasis 1 week after her second cycle of pembrolizumab. The patient developed extensive thin scaly psoriatic papules and plaques (psoriasis area and severity index (PASI) 9.1, body surface area (BSA) 40%) involving her abdomen, back, arms and legs. Two months before the start of pembrolizumab, she had psoriatic plaques (PASI 0.9, BSA 5%) treated only with topical 0.1% betamethasone valerate cream, urea 10% cream and coal tar 25% shampoo. We initiated adalimumab given the extent of BSA involvement and severity of the flare of chronic plaque psoriasis. Two months later, her psoriasis improved (PASI 9, BSA 19%) and pembrolizumab was continued. Eight months after the initiation of adalimumab, her chronic plaque psoriasis remained stable and her cholangiocarcinoma remained in remission. We hope to share our experience of using biologics to attain prompt control of ICI‐mediated psoriasis.
Kidney bean: Protein's treasure trove and creates avenues for a healthy lifestyle
Authors: Srenuja Dekka , Hema Vincent , Anand Maria Tito , Mohan Rangarajan Jagan , Vidyalakshmi Rajagopal 
Published: March 2023

AbstractKidney beans (KBs) are a nutrient‐dense and inexpensive legume crop that plays a crucial role in ensuring food security and is consumed globally. They are a treasure trove of nearly 20–30% protein, called vicilin or phaseolin, and these beans are also fair sources of vitamins, minerals, antioxidants, and bioactive compounds. These protein compounds have significant potential as plant‐based protein sources, owing to their functional properties and nutritional benefits. The current article provides an enthralling insight into the nutritional profile, constraints on its usage, production, and other basic details of KB. It highlighted the processing technology of the kidney bean protein isolates (KBPIs), and an in‐depth discussion was done on the KBPI's structural and functional traits to explore their potential, which is helpful in the formulation of novel foods and beverages. In the present scenario, KBPI in large‐scale industrial applications is skimpy; hence, the present article provides the applications of KB proteins in foods and edible films, which could be beneficial in the futuristic world. The current article opens up new avenues for investigating the utilization of KBs and their proteins in research and development (R&D) and manufacturing. This approach encourages further exploration of KB and their proteins in R&D, manufacturing, and commercialization. Such efforts have the potential to add significant value to KBs, promote healthy lifestyles among consumers, and boost the economy. Overall, the article presents a compelling case for expanding the utilization of KB in various applications, highlighting the possibilities for innovation and Legume Science development in this area.
Effect of anionic surfactants as pitting corrosion inhibitors for stainless steels
Authors: Yalcinkaya Mustafa Onur , Gaspard Alix , Altenbach Christoph , Zander Daniela 
Published: March 2023

AbstractAlthough anionic surfactants have been widely introduced as inhibitors against uniform corrosion, their efficiency as pitting inhibitors remains unclear. Herein, fatty alcohol ether sulfate (FAES), linear alkylbenzene sulfonate (LAS), and palm kernel oil (PKO) were tested for a Ti‐stabilized (1.4510) and a nonstabilized grade (1.4016) of ferritic stainless steel in alkaline chloride solutions containing H2O2. Electrochemical impedance spectroscopy (EIS) measurements were performed to elucidate the adsorption of surfactants at OCP, followed by potentiodynamic polarization. For 1.4510, LAS and FAES did not significantly affect the EIS results but inhibited pitting initiation with identical efficiencies. In the case of 1.4016, Cr‐rich carbides acted as adsorption sites, where LAS showed higher efficiency than FAES. While LAS and FAES interact preferentially with pitting initiation sites, PKO appears to adsorb randomly on the passive film. Consequently, inhibition can reach a maximum due to the electrical neutralization of the surface. Finally, LAS can be effective as an inhibitor for stainless steel containing carbides that can lead to pitting initiation.
Acute coronary event (ACE) prediction following breast radiotherapy by features extracted from 3D CT, dose, and cardiac structures
Authors: Choi Byong Su , Yoo Sang Kyun , Moon Jinyoung , Chung Seung Yeun , Oh Jaewon , Baek Stephen , Kim Yusung , Chang Jee Suk , Kim Hojin , Kim Jin Sung 
Published: March 2023

AbstractPurposeHeart toxicity, such as major acute coronary events (ACE), following breast radiation therapy (RT) is of utmost concern. Thus, many studies have been investigating the effect of mean heart dose (MHD) and dose received in heart sub‐structures on toxicity. Most studies focused on the dose thresholds in the heart and its sub‐structures, while few studies adopted such computational methods as deep neural networks (DNN) and radiomics. This work aims to construct a feature‐driven predictive model for ACE after breast RT.MethodsA recently proposed two‐step predictive model that extracts a number of features from a deep auto‐segmentation network and processes the selected features for prediction was adopted. This work refined the auto‐segmenting network and feature processing algorithms to enhance performance in cardiac toxicity prediction. In the predictive model, the deep convolutional neural network (CNN) extracted features from 3D computed tomography (CT) images and dose distributions in three automatically segmented heart sub‐structures, including the left anterior descending artery (LAD), right coronary artery (RCA), and left ventricle (LV). The optimal feature processing workflow for the extracted features was explored to enhance the prediction accuracy. The regions associated with toxicity were visualized using a class activation map (CAM)‐based technique. Our proposed model was validated against a conventional DNN (convolutional and fully connected layers) and radiomics with a patient cohort of 84 cases, including 29 and 55 patient cases with and without ACE. Of the entire 84 cases, 12 randomly chosen cases (5 toxicity and 7 non‐toxicity cases) were set aside for independent test, and the remaining 72 cases were applied to 4‐fold stratified cross‐validation.ResultsOur predictive model outperformed the conventional DNN by 38% and 10% and radiomics‐based predictive models by 9% and 10% in AUC for 4‐fold cross‐validations and independent test, respectively. The degree of enhancement was greater when incorporating dose information and heart sub‐structures into feature extraction. The model whose inputs were CT, dose, and three sub‐structures (LV, LAD, and RCA) reached 96% prediction accuracy on average and 0.94 area under the curve (AUC) on average in the cross‐validation, and also achieved prediction accuracy of 83% and AUC of 0.83 in the independent test. On 10 correctly predicted cases out of 12 for the independent test, the activation maps implied that for cases of ACE toxicity, the higher intensity was more likely to be observed inside the LV.ConclusionsThe proposed model characterized by modifications in model input with dose distributions and cardiac sub‐structures, and serial processing of feature extraction and feature selection techniques can improve the predictive performance in ACE following breast RT.
Antimuscarinic actions on bladder urothelium and lamina propria contractions are similar to those observed in detrusor smooth muscle preparations
Authors: Veer Vineesha , Chess‐Williams Russ , Moro Christian 
Published: March 2023

AbstractObjectivesAntimuscarinic medications are the first‐line treatments for overactive bladder, the most common form of bladder dysfunction. Their primary action is thought to block detrusor muscarinic receptors. It is unclear, however, if these therapeutics have actions on other tissues within the lower urinary tract. This study assessed whether clinical antimuscarinics have a functional impact on urothelium with lamina propria (U&LP) tissue.MethodsStrips of porcine detrusor and U&LP were mounted in carbogen‐gassed Krebs‐bicarbonate solution at 37°C. The tissues were paired with carbachol‐response curves performed in the absence or presence of each antimuscarinic. pEC50 values for each curve were analyzed and estimated affinities calculated.ResultsBoth detrusor and U&LP tissues contracted with muscarinic receptor stimulation, which was inhibited by commonly used antimuscarinics. In detrusor samples (p < 0.001 for all), right parallel shifts from the control were observed in response to oxybutynin (1 µM), solifenacin (1 µM), tolterodine (1 µM), darifenacin (100 nM), trospium (100 nM) and fesoterodine (100 nM). This shift was consistent in U&LP samples, with no significant differences between the two layers.ConclusionsThe data suggests that clinical antimuscarinics are as effective at inhibiting tonic contractions of the U&LP as they are on detrusor, presenting the U&LP as an alternate target of these medications in the treatment of lower urinary tract symptoms.
A thematic analysis of fundraiser characteristics in high‐quality major donor fundraising relationships inUShigher education
Authors: Shaker Genevieve G. 
Published: March 2023

AbstractAs nonprofits increasingly rely on large contributions, skillful major gift fundraisers are more important than ever. In contrast to the vast research on donor motivations, there are few examinations of fundraisers or fundraising relationships. This study responds to nonprofits' interest in understanding beneficial fundraising strategies and to the lack of empirical literature with the question: From the donor perspective, what characteristics do fundraisers demonstrate within high‐quality major giving relationships? This exploratory, interview‐based project used a codebook thematic analysis approach based on HEXACO personality theory to review participants' reflections about fundraisers. The 20 participating donors had given between USD$10,000 and USD$40 million to select colleges and universities in the US Midwest region. This study confirms much of what fundraisers believe to be important to major gift donors, with added nuance about the complex form of professionalism donors appreciate. The fundraiser characteristics show several dual emphases, including on field expertiseandinterpersonal acumen, attention to donor concernsandinstitutional interests, patience with the gift‐making processandability to facilitate its progression, and attention to ethical practiceandempathetic interactions. The study shows the inner workings of the major giving relationship fundraising paradigm, reveals how societal perceptions of fundraisers are relevant for understanding donor preferences, and provides a framework for fundraisers to assess and enhance their interactions with major donors.
Yedoma sediments with gravel and rock debris inclusions: Characteristics and origin
Authors: Vasil'chuk Yurij K. 
Published: March 2023

AbstractYedoma ice complex sediments with large syngenetic ice wedges (IW) are usually observed in outcrops in river valleys on permafrost plains and on sea coasts and lake shores in the north of Siberia, Alaska, and Canada. Less frequently, they occur in mountainous and foothill regions of East Siberia, for example, in the Upper Kolyma Upland and in river valleys of the Eastern Sayan Range and the Anabar Plateau, as well as in Alaska and Yukon. The author's materials on gravelly Yedoma with IWs in the intermountain basins, on mountain slopes, and on sea coasts and lake shores are presented. The obtained data allow a conclusion that gravelly Yedoma has mainly alluvial, lacustrine, and colluvial origins with an insignificant participation of aeolian processes. Occurrence of the late Pleistocene gravelly deposits with large syngenetic IWs confirms a hypothesis of polygenetic origin of Yedoma.
Influence of different bio‐based and conventional packaging trays on the quality loss of fresh cherry tomatoes during distribution and storage
Authors: Korte Imke , Albrecht Antonia , Mittler Maureen , Waldhans Claudia , Kreyenschmidt Judith 
Published: March 2023

AbstractThe quality loss and shelf life of cherry tomatoes stored in different types of commercially available bio‐based packaging trays were analysed and compared with the reference materials, corrugated cardboard and recycled polyethylene terephthalate (rPET). During storage under conditions reflecting points in a regional German supply chain, typical quality parameters were investigated. Surface bacterial counts of the packaging materials were investigated before and after storage, and material parameters were determined for selected packaging.The results showed that groundwood pulp and sugar cane trays showed higher preserving characteristics of tomatoes in comparison with the references. During storage, weight loss was highest for tomatoes stored in polylactic acid (PLA). The highest increase in microbial count with 3.5 log10 units was observed after 20 days for tomatoes stored in packaging trays of bamboo. The lowest increase with 0.5 log10 units and 0.6 log10 units was recorded for tomatoes stored in packaging trays of groundwood pulp and grass paper, respectively. The results of the packaging parameters show the highest (411.0 N) and lowest (79.0 N) tensile strength for cellulose and groundwood pulp. The water absorption capacity ranged from <10 g/m2 (bamboo, cellulose) up to 211.2 g/m2 (corrugated cardboard).
Impact of residual pulmonary hypertension on long‐term outcomes after pulmonary endarterectomy in the modern era
Authors: Ishida Keiichi , Kohno Hiroki , Matsuura Kaoru , Sugiura Toshihiko , Sanada Takayuki J. , Naito Akira , Shigeta Ayako , Suda Rika , Sekine Ayumi , Masuda Masahisa , Sakao Seiichiro , Tanabe Nobuhiro , Tatsumi Koichiro , Matsumiya Goro 
Published: March 2023

AbstractResidual pulmonary hypertension (PH) negatively impacts long‐term results following pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH). We sought to reveal whether modern PH therapy with PH‐targeted medicine and balloon pulmonary angioplasty (BPA) improved long‐term results of residual PH after PEA. Long‐term findings of 80 patients who survived PEA between 2011 and 2019 were retrospectively investigated. One month after PEA, 30 patients developed residual PH defined as mean pulmonary artery pressure (mPAP) ≥25 mmHg, of whom 23 were treated by PH‐targeted medicine and 9 by BPA. Patients with residual PH acquired considerably better functional status and exercise capacity after PEA, however, exhibited significantly worse survival rates than those without. Eleven patients died during follow‐up: 8 patients with residual PH and 3 controls. Among patients with residual PH, the deceased had a significantly lower %decrease in mPAP from 1 month to 1 year following PEA (7.4 [−32.6 to 8.0] % vs. 10.4 [3.7−27.8] %, p = 0.03) and higher mPAP at 1 year following PEA (39.5 [33.25−42.5] vs. 27 [26−34] mmHg, p < 0.01) despite PH‐targeted medicine than the survived. No patients passed away from right heart failure, and there was no difference between the groups in CTEPH‐related mortality. Modern PH therapy was used to address the majority of residual PH. Long‐term survival after PEA was negatively impacted by residual PH, but it appeared that long‐term mortality was also correlated with unrelieved residual PH despite PH‐targeted medicine. Modern PH therapy may have enhanced functional status and excercise capacity, and averted fatal right heart failure.
Conceptualizing State Voluntary Aid Organizations in Disaster (SVOAD) effectiveness
Authors: Jensen Jessica 
Published: March 2023

AbstractVoluntary Organizations Active in Disaster (VOADs) exist at the national, state, regional, and local levels as a platform for sharing information and supporting coordination among nongovernmental organizations (NGOs) that support disaster response and recovery efforts in the United States. These entities are described as important in disaster response and recovery policy and plans and in disaster scholarship. Yet, virtually no research has explicitly examined these entities at any level. This research began to address this gap in the literature by exploring what State VOAD (SVOAD) effectiveness meant to current and past SVOAD chairs through semi‐structured interviews. A grounded theory approach was used to analyze data gathered. The result of this analysis is a grounded definition of SVOAD effectiveness and identification of its dimensions. This manuscript presents the definition and the evidence that supports it and discusses how this information may be applied to support practice and future research.
Motivation to learn science, emotions in science classes, and engagement towards science studies in Chilean and Spanish compulsory secondary education students
Authors: Membiela Pedro , Acosta Katherine , Yebra Miguel A. , González Antonio 
Published: March 2023

AbstractImportant factors in learning science include motivational variables (relevance of science learning for personal goals, self‐efficacy for learning science, and interest in a scientific career), emotional variables (boredom and enjoyment in science classes), and engagement variables (vigor, dedication, and absorption towards science studies). Data from 3034 Chilean and Spanish compulsory secondary education students was used to study the relationships between these variables, by means of a self‐report questionnaire analyzed using structural equation modeling (SEM). The model, tested for goodness of fit, showed that motivational variables predict emotions in science classes and explained 43% of boredom variance and 67% of enjoyment variance. Motivational and emotional variables explained the 73% variance in engagement toward science studies. Also seen is the essential role played by emotions that mediate between motivational variables in science learning and engagement towards science studies. When promoting engagement towards science studies, these results can be used to increase relevance of science learning to personal goals, self‐efficacy for learning science, and interest in a scientific career, besides reducing boredom, increasing enjoyment in science classes, and enhancing engagement towards science studies.