bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pretreatment radiomics power in evaluating neoadjuvant chemotherapy response and outcome for patients with head and neck squamous cell carcinoma: a systematic review and meta-analysis
Authors: Yu Yalian , Li Xinyao , Li Wei , Wang Hongbo , Wang Yan 
Published: February 2023

Abstract
Background: This study conducted a meta-analysis of the evaluation value of radiomics in predicting induction chemotherapy (IC) response and prognosis of the patients with head and neck squamous cell carcinoma (HNSCC). By using the method of radiomic to formulate individualized treatment plans for the patients with HNSCC, the survival rate of the patients could be improved while maintaining the normal physiological functions.
Methods: We systematically searched the relevant articles on radiomics predicting IC response and prognosis of the patients with HNSCC published before June 1, 2022. Meta-analysis was used to evaluate the power for radiomics in predicting the response and prognosis of patients with HNSCC to IC.
Results: A total of 16 articles with 8238 patients were included in the study. The predictive value of IC response in patients with HNSCC showed that the diagnostic AUC was 0.87 (0.83-0.89), the sensitivity was 0.85 (0.69-0.94), and the specificity was 0.77 (0.65-0.86). By using radiomics, patients were divided into high-risk group and low-risk group, IC was the protective factor in the high-risk group. The survival time of overall survival (OS) in IC group was 0.35 (95% CI: 0.25-0.49) compared with the non-IC group, the disease progression free survival time (PFS) was 0.38 (95% CI: 0.28-0.52), and the metastasis free survival time (DMFS) was 0.37 (95% CI: 0.26-0.53).
Conclusions: Radiomics has a good predictive ability for the response of patients with HNSCC to IC and the impact of prognosis. Radiomics will assist clinicians in making more individualized treatment decisions for patients with HNSCC.
Chronic wound microenvironment mediates selection of biofilm-forming multi drug resistant Staphylococcus epidermidis with capability to impair healing
Authors: Pastar Irena , Dinic Miroslav , Verpile Rebecca , Meng Jingjing , Marjanovic Jelena , Burgess Jamie , Plano Lisa , Hower Suzanne , Thaller Seth , Banerjee Santanu , Lev-Tov Hadar , Tomic-Canic Marjana 
Published: February 2023

Abstract

Venous leg ulcers (VLU) are the most common chronic wounds characterized by bacterial biofilms and perturbed microbiome. Staphylococcus epidermidis is primarily known as skin commensal beneficial for the host, however, some strains can form biofilms and cause infections. By employing shotgun metagenomic sequencing we show that genetic signatures of antimicrobial resistance, adhesion and biofilm formation in VLU isolates correlate with in vitro bacterial traits. We demonstrate that the capability of chronic wound isolates to form biofilms and elicit IL-8 and IL-1β expression in human ex vivo wounds, correlates with the non-healing outcomes in patients with VLU. In contrast, commensal strains were incapable of surviving in the human ex vivo wounds. We show that major fitness traits of S. epidermis from VLU involve genes for resistance to methicillin and mupirocin, while the biofilm formation relied on the minimal number of genetic elements responsible for bacterial binding to fibronectin and fibrinogen. This underscores the importance of the emergence of treatment resistant virulent lineages in patients with non-healing wounds.
CRISPR-AMRtracker: a novel toolkit to monitor the antimicrobial resistance gene transfer in fecal microbiota
Authors: Li Gong , Long Tengfei , Zhou Shiying , Xia Lijuan , Wan Lei , Diao Xiaoyuan , Gao Ang , He Yuzhang , Sun Ruan-Yang , Ren Hao , Fang Liang-Xing , Liao Xiao-Ping , Liu Ya-Hong , Chen Liang , Sun Jian 
Published: February 2023

Abstract
The spread of antibiotic resistance genes (ARGs), especially those on plasmids, poses a major risk to global health. However, the extent and frequency of ARG transfer in microbial communities among human, animal, and environmental sectors is not well understood due to a lack of effective tracking tools. We have developed a new fluorescent tracing tool, CRISPR-AMRtracker, to study ARG transfer. It combines CRISPR/Cas9 fluorescence tagging, fluorescence-activated cell sorting, 16S rRNA gene sequencing, and microbial community analysis. The tool integrates a fluorescent tag immediately downstream ARGs, allowing for gene transfer tracking without affecting host cell antibiotic susceptibility, fitness, conjugation, or transposition. Our experiments show that sfGFP-tagged plasmid-borne mcr-1 can transfer across different bacteria species in feces, including Escherichia, Shigella, Lactobacillus, Staphylococcus, Enterococcus, and Bacillus. CRISPR-AMRtracker offers a powerful tool for monitoring ARG transfer in microbiota communities and can inform strategies to combat the threat of antibiotic resistance.
Attenuated APC contributes to FGF12 expression and EC progression with an integrated multi-omics analysis
Authors: Song Yunfeng , Zhong Cheng , Hu Xiang , Huang Jian , Bian Yiding , He Qizhi , Li Yiran 
Published: February 2023

AbstractBackgroundEndometrial cancer (EC) is one of the most common gynecological cancer worldwide. The high-order chromatin structure plays an important role in gene expression regulation. In our previous research, the chromatin remodeling-related gene APC (adenomatous polyposis coli gene) is frequently mutated in endometrial cancer. In this study, we aimed to figure out the role of the APC gene in the chromatin remodeling of endometrial cancer and cancer progression.ResultsThe level of APC expression decreased in EC and cell migration assays revealed that APC know-down KLE cells showed increased cell migration ability. An integrated multi-omics analysis, including RNA-sequencing (RNA-seq), assay for transposable accessible chromatin by high-throughput sequencing (ATAC-seq) and Hi-C, between the control cell and APC and knockdown KLE cell was performed and revealed that FGF12 was identified as a differentially expressed gene (DEG) in the switched compartments, cell-specific boundaries, and loops by comparing hierarchical structures and highly expressed in APC knockdown KLE cells. Moreover, high expression of FGF12 indicated a poor prognosis.ConclusionsAPC expression decreased in EC tissues and loss of APC in EC promotes cell migration. Moreover, loss of APC gene expression may reprogram the chromatin architecture to increase FGF12 gene expression, activate tumorigenesis-rated AKT and MAPK (Erk1/2) signaling, and promote endometrial cancer progression. In addition, a high level of FGF12 expression indicated a poor prognosis in EC patients, which provides a novel therapeutic target for EC with low expression level APC.
UBR4 deficiency causes male sterility and developmental delay
Authors: Xie Shi-Ming , Lai Jia-Xuan , Liu Chu-Qiao , Zhang Xi-Xing , Lin Yong-Miao , Chen Xiao-Chuan , Qiao Jing-Da , Mao Yu-Ling 
Published: February 2023

Abstract
It has been established that UBR4 encodes E3 ubiquitin ligase, which determines the specificity of substrate binding during protein ubiquitination and has been associated with various functions of the nervous system but not the reproductive system. Herein, we explored the role of UBR4 on fertility and development with a drosophila model. Different UBR4 knockdown flies were established using the GAL4/upstream activating sequence system. Fertility, hatchability and testis morphology were studied, and bioinformatics analyses were conducted. Our results indicated that UBR4 deficiency could promote larvae developmental delay and male drosophila fertility. We found that UBR4 deficiency affected the testis during morphological analysis. Bioinformatics analysis indicated 188 upregulated proteins and 175 downregulated proteins in the testis of UBR4 knockdown flies. Gene Ontology analysis revealed that significant upregulation of Sfp65A and downregulation of Pelota were involved in the reproductive process in drosophila, important in testis generation and sperm storage promotion. Overall, our findings suggest that UBR4 deficiency could promote male infertility in drosophila and may be involved in the protein modification of UBR4 by upregulating Sfp65A anddownregulating Pelota protein expression.
Assessing Knowledge and Awareness of Thromboprophylaxis before surgical intervention, among senior year medical students at Syrian private university (SPU)- a cross sectional study.
Authors: Aljasem Zahraa , Alraqmani Najwa 
Published: February 2023

Abstract
Background
Venous thromboembolism (VTE) is a major public health challenge globally due to its high morbidity and mortality. The condition is often asymptomatic and underdiagnosed due to la ack of awareness of VTE risk factors and thromboprophylaxis.
Methods
This cross-sectional study was conducted in April 2022 using an appropriate sampling pattern among students of the Faculty of Medicine at the Syrian Private University. A self-administered questionnaire was used. Ethical approval was obtained from the Institutional Review Board (IRB), Faculty of Medicine, Syrian Private University.
Results
The sample in our study consisted of 140 students, where awareness was surveyed about the use of venous thrombosis prevention before surgery. be without clinical symptoms 94 students answered “yes” (67%), the largest number of students knew that prolonged immobilization “predisposes to deep venous thrombosis in hospitalized patients” by 94%, and the largest number of students answered that obesity may lead to venous thrombosis Deep venous thrombosis with a percentage of 94%, 105 students answered yes when asked whether intravenous catheters could predispose to deep venous thrombosis by 75%, and when asked whether venous thrombosis was a sudden cause of death in hospitalized patients, 86 students answered yes with a percentage of 61%, and when asked as to whether prolonged hospitalization may increase predisposition to developing deep vein thrombosis by 8-fold, the largest number of students, 106, answered yes by 76%.
Conclusion
The results of our study conclude to an acceptable degree of awareness among medical students in the Syrian Private University regarding thromboprophylaxis.
Doria, Pedro. Fascismo à brasileira: como o integralismo, maior movimento de extrema-direita da história do país, se formou e o que ele ilumina sobre o bolsonarismo. São Paulo: Planeta, 2020.
Authors: Schargel Sergio 
Published: February 2023

Reseña del libro: Doria, Pedro. Fascismo à brasileira: como o integralismo, maior movimento de extrema-direita da história do país, se formou e o que ele ilumina sobre o bolsonarismo. São Paulo: Planeta, 2020.Fascismo à brasileira, de Pedro Dória, aproveita a onda de livros sobre recessão democrática para discutir, por meio de técnicas de New Journalism, a relação entre Integralismo e Bolsonarismo. Esta resenha discute alguns elementos-chave que aparecem no trabalho, em vista a iluminar os aspectos positivos e negativos da abordagem de Dória. Em que pese a escrita fluída do autor, transformando uma discussão densa em um estilo de prosa analítica, o livro não adentra em profundidade pontos essenciais desses movimentos de extrema-direita, e tangencia a relação que se propõe a fazer.
Initiation of Continuous Glucose Monitoring Is Linked to Improved Glycemic Control and Fewer Clinical Events in Type 1 and Type 2 Diabetes in the Veterans Health Administration
Authors: Reaven Peter D. , Newell Michelle , Rivas Salvador , Zhou Xinkai , Norman Gregory J. , Zhou Jin J. 
Published: February 2023

OBJECTIVE
To determine the benefit of starting continuous glucose monitoring (CGM) in adult-onset type 1 diabetes (T1D) and type 2 diabetes (T2D) with regard to longer-term glucose control and serious clinical events.

RESEARCH DESIGN AND METHODS
A retrospective observational cohort study within the Veterans Affairs Health Care System was used to compare glucose control and hypoglycemia- or hyperglycemia-related admission to an emergency room or hospital and all-cause hospitalization between propensity score overlap weighted initiators of CGM and nonusers over 12 months.

RESULTS
CGM users receiving insulin (n = 5,015 with T1D and n = 15,706 with T2D) and similar numbers of nonusers were identified from 1 January 2015 to 31 December 2020. Declines in HbA1c were significantly greater in CGM users with T1D (−0.26%; 95% CI −0.33, −0.19%) and T2D (−0.35%; 95% CI −0.40, −0.31%) than in nonusers at 12 months. Percentages of patients achieving HbA1c &lt;8 and &lt;9% after 12 months were greater in CGM users. In T1D, CGM initiation was associated with significantly reduced risk of hypoglycemia (hazard ratio [HR] 0.69; 95% CI 0.48, 0.98) and all-cause hospitalization (HR 0.75; 95% CI 0.63, 0.90). In patients with T2D, there was a reduction in risk of hyperglycemia in CGM users (HR 0.87; 95% CI 0.77, 0.99) and all-cause hospitalization (HR 0.89; 95% CI 0.83, 0.97). Several subgroups (based on baseline age, HbA1c, hypoglycemic risk, or follow-up CGM use) had even greater responses.

CONCLUSIONS
In a large national cohort, initiation of CGM was associated with sustained improvement in HbA1c in patients with later-onset T1D and patients with T2D using insulin. This was accompanied by a clear pattern of reduced risk of admission to an emergency room or hospital for hypoglycemia or hyperglycemia and of all-cause hospitalization.
Mengembangkan Kemampuan Self-Regulated Learning Bidang Metakognisi
Authors: Kristanto Andi , Pradana Hirnanda Dimas 
Published: February 2023

Kemampuan self-regulated sangat penting untuk dimiliki oleh mahasiswa. Hal ini mencakup perilaku, karena individu mengatur tindakan mereka untuk membuat mereka tetap berfokus pada pencapaian tujuan. Self regulated learning diperlukan oleh mahasiswa untuk dapat menjadikan dirinya pribadi yang bertanggung jawab atas dirinya. Penelitian ini bertujuan untuk menganalisis kebutuhan di lapangan terkait pengembangan self regulated learning dalam metakognisi mahasiswa. Subjek penelitian ini melibatkan 100 mahasiswa dari program studi teknologi pendidikan. Penelitian deskriptif kualitatif ini dilakukan dengan metode survei. Pengumpulan data menggunakan kuesioner. Lembar kuesioner digunakan untuk mengumpulkan data tentang self regulated learning mahasiswa program studi teknologi pendidikan. Analisis data dilakukan secara deskriptif kualitatif dari data penelitian dilakukan. Berdasarkan temuan investigasi yang dilakukan, terlihat bahwa self regulated learning sangat dibutuhkan dalam pembelajaran di tingkat universitas. Mahasiswa membutuhkan pembelajaran yang bisa meningkatkan kemandirian belajar dalam diri mereka serta bisa menjadi pribadi yang jauh lebih baik. Langkah selanjutnya yang diperlukan adalah mengembangkan pembelajaran berbasis self regulated learning untuk mahasiswa teknologi pendidikan.
Media Presentasi pada Mata Pelajaran IPA Siswa Kelas V SD
Authors: Eva Mayasari  , I Komang Sudarma  , Alexander Hamonangan Simamora  
Published: February 2023

Guru kesulitan dalam berinovasi mengembangkan sebuah pembelajaran berbasis digital. Hal ini berdampak pada motivasi dan hasil belajar siswa yang rendah. Tujuan penelitian ini yaitu mengembangkan media persentasi pada mata pelajaran IPA untuk siswa kelas V SD. Jenis penelitian ini yaitu pengembangan dengan model ADDIE. Subjek penelitian ini yaitu 1 ahli mata pelajaran, 1 ahli media pembelajaran, dan 1 ahli desain pembelajaran. Subjek uji coba siswa berjumlah 32 siswa. Metode pengumpulan data yaitu wawancara, observasi, dan kuesioner. Instrument pengumpulan data yaitu kueioner. Teknik menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu penilaian ahli isi pelajaran yaitu 95,8% (sangat baik). Hasil penilaian dari ahli media pembelajaran yaitu 95,8% (sangat baik). Hasil penilaian dari ahli desain pembelajaran yaitu 5% (baik). Hasil uji coba perorangan yaitu 96,66% (sangat baik) dan uji coba kelompok kecil yaitu 98% (sangat baik). Disimpulkan bahwa media presentasi layak digunakan dalam pembelajaran. Media persentasi membantu siswa belajar IPA sehingga motivasi belajar menjadi meningkat.
Aktivitas senyawa antioksidan Scurrula ferruginea (Jack) Dans dengan inang Kakao (Theobroma cacao)
Authors: Pratama Novia Mayang , Salni Salni , Marisa Hanifa 
Published: February 2023

Antioksidan adalah senyawa yang mampu menghambat radikal bebas yang dapat menyebabkan penyakit dalam tubuh dan dapat diisolasi dari tanaman. Benalu merupakan salah satu tanaman yang mengandung flavonoid, tanin, terpenoid dan alkaloid. Scurrula ferruginea (Jack) Dans dengan inang kakao (Theobroma cacao) diasumsikan memiliki senyawa antioksidan. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan fraksi n-heksana, etil asetat dan metanol dari daun Scurrula ferruginea, untuk menentukan kelompok senyawa murni yang memiliki antioksidan dan untuk menentukan nilai IC50 dari senyawa antioksidan murni. Metode penelitian dimulai dengan persiapan sampel, ekstraksi, fraksinasi cair-cair, isolasi senyawa dengan kromatografi cair vakum dan kromatografi kolom dan uji aktivitas antioksidan menggunakan metode DPPH. Penelitian ini menunjukkan bahwa fraksi etil asetat memiliki aktivitas kuat dan diikuti oleh fraksi n-heksan, sedangkan fraksi metanol memiliki aktivitas lemah. Isolat antioksidan aktif dalam fraksi n-heksan adalah senyawa H1 dan H2.1 dengan senyawa terpenoid. Sedangkan dalam fraksi etil asetat menghasilkan satu senyawa aktif, E1.1. dengan kelas senyawa flavonoid. Hasil penentuan aktivitas antioksidan dengan metode DPPH menunjukkan nilai IC50 pada senyawa H1, H2.1 dan E1.1. masing-masing 127,46; 129.28 dan 92.3 ppm. Senyawa H1 dan H2.1. memiliki aktivitas antioksidan sedang dan senyawa E1.1 memiliki aktivitas antioksidan yang kuat.
Cefiksym – doustna cefalosporyna III generacji dla dzieci
Authors: Sybilski Adam J. , Kudan Małgorzata 
Published: February 2023

Cefiksym to półsyntetyczny antybiotyk β-laktamowy, cefalosporyna III generacji do stosowania doustnego zarówno u dzieci (rejestracja od 6. m.ż.), jak i u dorosłych. Wykazuje on silne działanie bakteriobójcze w mechanizmie hamowania biosyntezy ściany komórkowej bakterii. Spektrum działania to: Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Proteus mirabilis. Wskazaniami klinicznymi do zastosowania cefiksymu u dzieci są: pozaszpitalne zapalenie płuc, zapalenie dolnych dróg moczowych, odmiedniczkowe zapalenie nerek, zapalenie ucha środkowego, zapalenie zatok, zapalenie gardła. Dane z badań klinicznych jednoznacznie wskazują na wysoką skuteczność antybiotyku u dzieci i młodzieży, jednocześnie wykazując duże bezpieczeństwo i rzadkie działania niepożądane (głównie żołądkowo-jelitowe). Właściwości farmakokinetyczne i farmakodynamiczne sprawiają, że antybiotyk może być podawany raz na dobę, niezależnie od posiłków.
W artykule opisano trzy typowe przypadki zastosowania cefiksymu u dzieci. Przedstawiono dzieci leczone z powodu odmiedniczkowego zapalenia dróg moczowych, pozaszpitalnego zapalenia płuc i ostrego zapalenia ucha środkowego. Skuteczność, bezpieczeństwo, biodostępność, dobry smak oraz łatwy schemat dawkowania sprawiają, że cefiksym jest właściwą opcją antybiotykoterapii u dzieci.
Herpes simplex virus encephalitis mimicking acute ischemic stroke
Authors: Roçi Ermir , Dodaj Stela , Vyshka Gentian 
Published: February 2023

Background:Infections of the central nervous system might present in an acute form such as to be similar with the clinical characteristics of a stroke. This situation will hamper a correct diagnosis and a prompt treatment that can otherwise be successful.Case Description:We present the case of a herpes virus encephalitis that came up in the emergency department with an admission diagnosis of ischemic cerebral accident. Being the symptomatology unclear, the findings of magnetic resonance of the brain oriented versus an infectious disorder. The lumbar tap confirmed the presence of herpes simplex virus (HSV) 1 virus and an antiviral therapy was administered, leading to resolution of the condition within the 3 weeks of hospitalization.Conclusion:HSV infections may mimic stroke and therefore should be included in the differential diagnosis of atypical acute nervous conditions. In neurological events of acute nature, especially in febrile patients whose brain imaging is suspicious or inconclusive, the eventuality of a herpetic encephalitis should be kept in mind. This will lead to a prompt antiviral therapy and to a favorable outcome.
MODELING OF THE EFFECT OF EMITTER SPACER THICKNESS ON STATIC CHARACTERISTICS OF RESONANT TUNNELING DIODES
Authors: Гришаков К.С. 
Published: February 2023

В настоящей работе проводилось компьютерное моделирование статических характеристик резонансно-туннельных диодов в когерентной модели с учетом ряда особенностей, присущих эксперименту. Решалась стационарная система уравнений Шредингера и Пуассона с открытыми граничными условиями. Постановка задачи учитывала фермиевское распределение электронов по энергии, наличии спейсерных слоев и сильно легированных контактных областей. В результате проведенных исследований удалось установить, что уменьшение толщины спейсера эмиттера позволяет повысить величину пикового тока резонансно-туннельного диода. Результаты работы могут быть использованы для оптимизации гетероструктуры резонансно-туннельных диодов для использования их в качестве источников терагерцевого излучения.
A computer simulation of the static characteristics of resonant tunneling diodes in a coherent model taking into account a number of features inherent in the experiment was carried out. A stationary system of Schrodinger and Poisson equations with open boundary conditions was solved. The formulation of the problem took into account the Fermi distribution of electrons by energy, the presence of spacer layers and high doped contact regions. As a result of the conducted studies, it was found that reducing the thickness of the emitter spacer layer allows increasing the peak current of the resonant tunneling diode. The results obtained can be used to optimize the heterostructure of resonant tunneling diodes for their use as sources of terahertz radiation.
UNMANNED AERIAL VEHICLES OF RUSSIA AT THE INTERNATIONAL MILITARY-TECHNICAL FORUM ARMY-2022
Authors: Кузнецов Г.А. , Мальков А.Д. , Гильмияров М.Р. 
Published: February 2023

В статье проведен анализ беспилотных летательных аппаратов (БЛА) России, представленных на МВТФ «Армия-2022». Определены основные тенденции развития БЛА. За последние 5 лет отмечен рост количества моделей военных ударных и гражданских грузотранспортных БЛА.
The article analyzes the unmanned aerial vehicles (UAVs) of Russia presented at the IMTF Army-2022. The main trends in the development of UAVs have been identified. Over the past 5 years, there has been an increase in the number of models of military combat and cargo-carrying UAVs.