bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEX DIFFERENCES AND LONGITUDINAL QUANTILES OF FRAILTY TRAJECTORIES WITH MISSING DATA DUE TO DEATH
Authors: Marroig Alejandra , Massa Fernando , Hofer Scott , Terrera Graciela Muniz 
Published: December 2022

Abstract
Scarce evidence exists about frailty trajectories, but the evidence suggests that women live longer with higher levels of frailty. When progression of frailty was studied, the focus has been on mean trajectories and research has ignored death. Here, we aim to assess the role of sex, age, and education in different quantiles of the distribution of frailty trajectories. We derived a frailty index (FI, range 0–1) based on the accumulation of deficits in individuals aged 65 at baseline (n=6929) using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE). We applied weighted Generalized Estimating Equations (weighted GEE) to adjust the quantiles of the FI trajectory by sex, and education. The results show that the median FI trajectory increases with age (b_age0.5=0.008, p &lt; 0.001) and this increase is higher for women than men (b_age*sex0.5=0.003, p &lt; 0.001), but sex differences disappear for the most frail (0.9 percentile) once the missing data process is accounted for (b_age*sex0.9=0.002, p=0.085). For the most frail the increase with age is higher than for those at the median (b_age0.9=0.018, p &lt; 0.001; test diff, p &lt; 0.001) and education reduces the progression of the median FI (b_age*edu0.5=-0.0003, p &lt; 0.001). Our approach advances the understanding of frailty trajectories of older adults, showing differences across quantiles. Thus, this may improve the practice and design of interventions aimed at older adults. In addition, we address the process of missing information and the results show new insights, particularly for those who are most frail.
YOU’VE GOT A FRIEND: SOCIAL FACTORS AND DEPRESSIVE SYMPTOMS IN OLDER ADULTS
Authors: Fenstermacher Erika , Fiske Amy 
Published: December 2022

Abstract
Depression in late life is associated with disability, lower quality of life, increased mortality, and risk of suicide. Research suggests that functional disability, which is often brought about by a medical condition, may precede depressive symptoms and may be a major factor for older adults developing depression. Social support can be beneficial for both emotional and physical health. Numerous studies demonstrate that social networks, perceived and subjective social support, and satisfaction with support received moderate the relation between health problems and depression. Findings are mixed regarding received and objective social support and only one study was found that examined the impact of giving support to others. The current study addressed gaps in the literature by focusing on three facets of social relationships: availability of support, participant giving help, and participant receiving help. Data from the 2011 wave of the Wisconsin Longitudinal Study were used (N = 3906; mean age of 71.27; SD = .948). We examined the relationships between medical conditions, functional impairment, depressive symptoms, and social support using regression analyses. Medical conditions and functional impairment each independently predicted depressive symptoms. Availability of support significantly predicted lower levels of depressive symptoms and amount of help received predicted higher levels of depressive symptoms, controlling for medical conditions and functional impairment. These findings suggest that simply having someone available, not necessarily interacting with them for help, could reduce depressive symptoms in older adults.
ARE OLDER ADULTS’ SOCIAL PARTICIPATION AND RELATIONSHIP QUALITY RELATED TO THEIR SPOUSE’S COGNITION?
Authors: Peng Changmin , Lin Yan , Qu Shan , Yuan Yiyang 
Published: December 2022

Abstract
Limited studies have quantified older adults’ profiles of social participation and relationship quality. How such profiles were associated with their spouse/partner’s cognitive function also remains unknown. Using the Health and Retirement Study (2014/2016), we identified 3,722 community-dwelling, cognitively intact, married/partnered respondents living with their spouse/partner. Spouse/partner’s cognitive function was ascertained by the Langa-Weier Classification [Intact/Cognitively Impaired but not Demented (CIND)/Demented]. Social participation was measured by the frequency of volunteer, charity, education, sport/social clubs, and non-religious organization activities. Relationship quality was measured by the perceived positive and negative support from spouse, children, relatives, and friends. Latent profile analysis identified profiles of social participation and relationship quality. Multinomial logistic regression estimated the association between spouse/partner’s cognitive function and the respective profiles. Three social participation profiles were identified: (1) Limited social participation (prevalence: 69%; reference); (2) Frequent volunteer participation (10%); (3) Frequent non-volunteer participation (21%). Three relationship quality profiles were identified: (1) Positive overall support (68%; reference); (2) Positive spousal support (18%); (3) Negative spousal support with positive non-spousal support (14%). Those with a spouse/partner that were CIND or demented were significantly less likely to frequently participate in volunteer or non-volunteer activities, while more likely to perceive negative spousal support and positive non-spousal support. Given these findings and the essential role of social participation and relationship quality in older adults’ well-being, programs focusing on older adults living with a spouse/partner with impaired cognition are needed to help them maintain social connectedness.
INVOLUNTARY JOB LOSS AND GENDERED HEALTH OUTCOMES IN MIDDLE AGE AND LATER LIFE: A LIFE COURSE ANALYSIS
Authors: Song Qian , Connelly Caitlin 
Published: December 2022

Abstract
Job loss is associated with a range of negative health outcomes. However, the causality of job loss and poor health is unclear, due to issues of endogeneity and reverse causality (i.e., adverse health causing job loss). We also need a better understanding of the long-term effects of job loss, and how the life stage in which job loss occurred yields different health outcomes for women and men in later life. To address these gaps, we take advantage of a quasi-experimental setting — the policy-driven layoffs of the State-Owned-Enterprises (SOEs) during the 1990s – mid-2000s in urban China. Using the life history survey of the China Health and Retirement Longitudinal Study 2014 and the 2015 wave, we examine the long-term effects of job loss on self-rated health (scored 1 – 5) of individuals in middle age and later life (aged 45+). After controlling for individual childhood health, life-time work history, as well as demographics and socioeconomic status, results from linear regressions show that overall, job loss from SOEs reduces self-rated health by 0.12 (p &lt; .05) for both women and men. However, job loss hurts females’ self-rated health the most when job loss occurred in early-life, a life stage in which childbearing and child caregiving were most intensive (aged 35 or earlier; β = -0.24, p &lt; .05), whereas males’ self-rated health is hardest hit if job loss occurred in mid-life (aged 36 – 45; β = -0.35, p &lt; .01). The results suggest that involuntary job loss produce gendered health outcomes due to gendered life courses.
RURAL AGE-FRIENDLY ECOSYSTEMS: A SCOPING REVIEW WITH RECOMMENDATIONS FOR AGE-FRIENDLY COMMUNITIES
Authors: Liebzeit Daniel , Krupp Anna , Bunch Jacinda , Buck Harleah 
Published: December 2022

Abstract
The population of older adults in rural areas is rising, and they experience higher rates of poverty and chronic illness, have poorer health behaviors, and experience different challenges than those in metropolitan areas. Promoting age-friendly rural communities and healthcare is key to improving outcomes and addressing disparities. This international scoping review seeks to 1) map the state of the science of age-friendly systems in rural areas regarding structural characteristics, processes for delivering age-friendly practices, and outcomes of age-friendly systems, 2) analyze strengths, weakness, opportunities, and threats of age-friendly system implementation, and 3) make person, practice, and policy-level recommendations to support active aging. Articles were retrieved from PubMed, CINAHL, AgeLine, PsychINFO, EMBASE, Scopus, and Academic Search Elite on 10/26/21 and included if they used age-friendly framing, self-identified as rural, and reported empiric data. Data were charted across three analytic layers: socioecological model, Donabedian’s framework, and SWOT analysis. While age-friendly systems in this review were heterogeneous, many utilized the World Health Organization age-friendly cities framework. Results reveal limited data on outcomes relevant to organizations. While the SWOT analysis revealed many strengths of age-friendly systems, it also revealed several weaknesses, threats, and gaps. Weaknesses included over-reliance on trained volunteers and staff, communication, and teamwork. Threats included community and health system barriers and challenges in developing regions. Despite the benefits of age-friendly systems, we must acknowledge limitations of the evidence base, pursue opportunities to examine organizational metrics to support implementation and sustainability of age-friendly systems, and leverage improvements in age-friendliness at a community level.
INVESTIGATING OLDER ADULTS’ PERSPECTIVES ON TELEHEALTH ROBOTICS
Authors: Olatunji Samuel , Hussaini Husna , Blocker Kenneth , Uppalapati Naveen , Krishnan Girish , Rogers Wendy 
Published: December 2022

Abstract
The current social distancing directives have heightened the need for older adults to seek remote healthcare solutions. Telehealth robots could support home health by carrying out on-demand tasks for diagnosis and treatment at the user’s home through remote teleoperation by the healthcare provider. Acceptability of such telehealth robots by older adults is critical to their successful deployment. The overall goal of this research was to investigate older adults’ perceptions and attitudes towards a telehealth robot supporting health checkups at home. Specific objectives were to explore potential healthcare use cases for the robot; identify facilitators and barriers to its use; and elicit design requirements for use in healthcare contexts. We interviewed 5 men and 5 women (ages 66–73) after they viewed a series of videos demonstrating the potential uses of the telehealth robot. The older adults had positive first impressions towards the telehealth robot and were generally open to the idea of using it for telehealth tasks. They conveyed a high level of trust with the robot, especially if it were controlled by a healthcare provider, yet expressed concerns with privacy and security of health information that would need to be addressed in the design of security protocols. They described added value of the robot’s healthcare support while suggesting potential improvements to the robot. This research provided insights into older adults’ perceptions and attitudes towards a telehealth robot as well as identified potential healthcare use cases that would inform the design requirements for telehealth robots in different home healthcare contexts.
COMMUNITY-RECRUITED OLDER ADULTS DIFFER FROM PATIENT POPULATIONS
Authors: Striley Catherine , Chaudhari Piyush , Fillingim Roger , Cottler Linda 
Published: December 2022

Abstract
Researchers often conduct randomized controlled trials among patient populations that may not reflect the community in which findings will be translated. The University of Florida’s community engagement program HealthStreet provides a diverse sample in which to consider differences between people 65 years of age and older who have seen a physician in the past 12 months and those who have not. This provides a conservative test of potential biases in patient-only samples. Based on a sample of 1,663 people, 65 years of age and older, who were recruited by Community Health Workers in the North Florida region from November 2011 through July 2022, 88% had seen a physician in the past 12 months. Those who had not (12%) were significantly more likely to be non-white than white, to be in good/excellent than fair/poor health, and significantly less likely to have a range of health conditions including high blood pressure, depression, heart conditions, diabetes, a digestive health condition, a dental health condition, or cancer. Yet residents who hadn’t seen a doctor were just as likely to be willing to participate in a future health study (both 94%) that only asked about health, accessed medical records (both 87%) or didn’t provide reimbursement (both 81%), and were not significantly different in attitudes toward participating in research in general. Recruiting of older adults should be conducted in the community, not just in patient populations, which are likely to be less diverse and sicker than those recruited through a community engagement program.
THE SOCIAL COST OF MODIFIABLE RISK FACTORS IN SINGAPORE
Authors: Tan Vanessa , Ma Stefan , Chen Cynthia 
Published: December 2022

Abstract
Close to half of total disease burdens are attributable to modifiable risk factors, indicating that many illnesses are preventable by modifying behaviours such as increasing physical activity levels or maintaining a healthy diet. This study measures the social costs attributable to modifiable risks in Singapore, one of the most rapidly ageing populations in the world. Measuring the social cost of modifiable risk factors can help public health policymakers prioritise public health programmes and allocate resources. Our study builds on the comparative risk assessment framework from the Global Burden of Disease study. We used a prevalence-based cost-of-illness approach to estimate the social cost attributable to modifiable risk factors. We included healthcare costs from inpatient hospitalisation and productivity losses from absenteeism and premature mortality. Our results found that metabolic risks had the highest social cost of S$2.20 billion in 2019, followed by lifestyle risks of S$1.98 billion and substance risks of S$1.56 billion. Across the risk factors, the social costs were largely driven by productivity losses, heavily skewed towards the older working-age group. For metabolic risks, approximately 80% of the total cost (S$1.82 billion) was from those aged above 45 years old. This study provides evidence of the high social cost of modifiable risks and highlights the importance of developing holistic public health promotion programmes. Our findings suggest that implementing effective population-based programmes targeting multiple modifiable risks would have a strong potential to manage rising disease burdens and healthcare costs, especially with an ageing population.
IFIT3 GENE EXPRESSION AND FUNCTION CONTRIBUTE TO HAND PATHOLOGY EVEN WITH ANTIRETROVIRAL THERAPIES (CARTS)
Authors: Das Ranjit Kumar , Roy Deepa , Sahoo Nirakar , Roy Upal 
Published: December 2022

Abstract
The advent of cART has revolutionized the management of HIV-1 infection and saved the lives of millions of people worldwide. Yet, HIV-Associated Neurocognitive Disorder (HAND) continues to be clinically relevant with aging people with HIV-1 (PWH). The underlying mechanism of HAND remains poorly understood. In this regard Signal transducer and activator of transcription 1(STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have been shown to induce neuroinflammation and neuronal cell death. However, the role of IFIT3 in HAND pathology has not been well established. Therefore, the present work investigated the significant role of IFIT3 gene in the development of HAND. In the current study, we used an in-vitro model to expose the neuroblastoma cell-line SH-SY5Y with clinically relevant cARTs drug and HIV Tat protein to observe the STAT1 and IFIT3 genes dysregulation. Furthermore, study also investigates the STAT1 and IFIT3 protein dysregulation through immunocytochemistry and western blot assay. Overall observation indicated that HIV-Tat protein upregulated gene expression whereas with the cART exposure there was a downregulation of STAT1 and IFIT3 genes. We next aim to investigate the role of STAT1 and IFIT3 genes in HIV-induced neuroinflammation. The current study has established IFIT3 as a biomarker marker for the detection of HAND.
AGING DRAG QUEENS: RISKS, REWARDS, EXPRESSION AND PERFORMANCE
Authors: Donorfio Laura , Chapman Brian , Henneberry Kathleen 
Published: December 2022

Abstract
This poster presentation will share the exploratory findings of a qualitative research study examining the lived experiences of older drag queens, age 50+. Drag queens are an understudied and underrepresented population in the social science literature (Knutson, Koch, Sneed, Lee, & Chung, 2020; O’Brien, 2018). Older drag queens have yet to be studied in the social science literature. “Drag Queens possess unique characteristics as a subpopulation of the lesbian, gay, bisexual, and transgender (LGBT) community that warrant exploration” (Knutson, Koch, Sneed, & Lee, 2018). A comprehensive literature review identified approximately a dozen research driven articles from 2004 to the present, studying such areas as motivations, obstacles and stressors in becoming and being a drag queen (Hopkins, 2004; Knutson et al., 2021), depression, substance abuse, and resilience (Knutson et al., 2019; Tillewein & Kruse-Diehr, 2021) and the role gender plays via sexuality identities (Taylor & Rupp, 2004, Levitt et al. 2017). This research seeks to better understand how drag expression is integrated with one’s persona and how it interfaces with dragism, coping, and if drag expression can be used as a tool to foster resilience. Using a semi-structured interview protocol and thematic analysis, many themes emerged including the risks and rewards associated with drag expression, the relationship between aging and being a drag performer, and the shift in traditional versus 21st century drag. Lastly, we highlight the implications for gender and LGBTQIA+ theory and plans for future research.
PASSING THE TORCH: EXPLORING THE SUSTAINABILITY OF AN INTERPROFESSIONAL GERIATRICS FACULTY DEVELOPMENT PROGRAM
Authors: Davis Kimberly , Marrs Sarah , Williams Ishan , Zimmerman Kristin , Coogle Constance , Parsons Pamela , Slattum Patricia , Waters Leland 
Published: December 2022

Abstract
Faculty development programs (FDPs) are an effective, evidence-based method of promoting the knowledge, skills and self-efficacy of faculty. However, the implementation and sustainability of curricula are rarely reported. Furthermore, the challenges to sustaining programmatic implementation of interprofessional FDP curricula in academic and clinical settings over time have yet to be extensively evaluated. Using dynamic sustainability as a framework, we aimed to assess the evolving barriers and facilitators that influence the implementation and sustainability of the geriatrics curriculum Capstone projects designed by faculty scholars in our FDP. We planned to report on projects that were and weren't successful. A survey, sent to 115 faculty scholars from eight different cohorts who completed our 10-month FDP, recruited faculty participants and set the stage for qualitative data collection to help us better understand the sustained impact of the program. Thematic analysis of virtual interviews with 17 Scholars revealed several key factors facilitating and hindering the implementation and dynamic sustainability of curricular projects. Three major themes and sub-themes were identified as follows: Project Implementation (Supportive Factors, Hindering Factors and Filling in Gaps in the Field); Pedagogical Development (Enhancement of Skills and Culture Change); and Sustainability Impact (Project Sustainability, Career Development and Passing the Torch). Supporting these factors through skills development may favorably impact project sustainability and thus the aspects of workforce development that catalyze practice change. Implementation of geriatrics-focused FDPs provides an evidence-based approach to sustainability. Further study of the ongoing barriers and facilitators to sustainability is encouraged.
A COMPARISON OF SUBJECTIVE COGNITIVE DECLINE AND RELATED LIMITATIONS AMONG TRANSGENDER COMMUNITIES IN THE US
Authors: Cicero Ethan , Goodman Michael , Barnes Lisa , Perkins Molly , Flatt Jason , Tangpricha Vin 
Published: December 2022

Abstract

Background
The transgender population is composed of subgroups that are diverse in gender identity (e.g., transgender women[TW], transgender men[TM], nonbinary[NB] individuals). Compared to cisgender adults, transgender adults are more likely to report subjective cognitive decline (SCD). It remains unclear if SCD prevalence and related limitations vary by transgender subgroups.

Methods
2015-2020 Behavioral Risk Factor Surveillance System data, representing 38 U.S. states that assessed SCD (confusion/memory loss happening more often/getting work over previous 12months) and gender identity were used to examine differences in SCD prevalence and SCD-related limitations by transgender subgroups, TW(n=442), TM(n=298), and NB(n=183). Age-adjusted odds ratios (OR) along with 95% confidence intervals (CI) were calculated to investigate group differences in SCD prevalence. Separate analyses compared SCD-related limitations, demographics, and health across groups among participants reporting SCD.

Results
SCD prevalence was highest among NB(21.3%), followed by TW(16.3%) and TM(14.1%). After accounting for age, subgroup differences remained; odds of SCD were 1.6x higher among TW compared to TM (CI:1.1–2.4, p=0.012). Among those with SCD, TW were less likely to receive help they needed with day-to-day activities when compared to TM (OR=7.9; CI:0.1–0.2, p&lt; 0.001) and NB (OR=5.0; CI:0.1–0.4, p=0.001); and TW were more likely to be deaf (OR=4.2; CI:1.7–10.1, p=0.002) and have asthma (OR=2.8; CI:1.4–5.7, p=0.005) when compared to NB adults. No other differences were found.

Conclusion
Health and social inequities are not uniformly experienced across transgender subgroups, and it is important to understand how these factors impact the brain health of TW, TM, and NB adults.