bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic behavior of dual filler system (n‐Si3N4/COOH‐MWCNT) on the mechanical, tribological, curing, and corrosion characteristics of epoxy hybrid nanocomposites
Authors: Bhagavatula Sai Gopal Krishna , Painkal Sarath Kumar , Nanoth Rasana , Murugasamy Kannan , Karingamanna Jayanarayanan 
Published: February 2023

AbstractEpoxy hybrid nanocomposites reinforced with silicon nitride nanoparticles (SiN) and carboxylic acid‐modified multiwalled carbon nanotubes (COOH‐MWCNT) were prepared by hand layup. These hybrid nanocomposites have not undergone thorough investigation in the fields of mechanical, tribological, and corrosion‐resistant characteristics. The 0.25/0.5 SiN/MWCNT hybrid nanocomposite displayed improvement in elongation by 190% and fracture toughness by 360%. The effect of dual filler system on the wear and friction properties of the composite was investigated. The influence of silicon nitride and hybrid fillers the curing characteristics of epoxy was examined using Fourier transform infrared spectroscopy (FTIR). From differential scanning calorimetry (DSC), it was found that the use of dual fillers in the epoxy system reduced the residual heat of reaction and curing time by 15%. In a highly corrosive environment (3.5% NaCl), TAFEL polarization showed that 0.5/0.5 SiN/MWCNT epoxy hybrid coating on mild steel (MS) increased protection against corrosion by 30%. The dispersion of nanofillers and their interactions were verified using high‐resolution transmission electron microscopy (HR‐TEM). The morphology of the fracture, wear, and corroded surfaces were examined by field emission scanning electron microscopy (FE‐SEM). SiN manifested a synergistic effect with MWCNTs making it a superior reinforcement at very low content.
Tumor‐derived insulin‐like growth factor‐binding protein‐1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors
Authors: Suzuki Hiroyuki , Iwamoto Hideki , Seki Takahiro , Nakamura Toru , Masuda Atsutaka , Sakaue Takahiko , Tanaka Toshimitsu , Imamura Yasuko , Niizeki Takashi , Nakano Masahito , Shimose Shigeo , Shirono Tomotake , Noda Yu , Kamachi Naoki , Sakai Miwa , Morita Kazutoyo , Nakayama Masamichi , Yoshizumi Tomoharu , Kuromatsu Ryoko , Yano Hirohisa , Cao Yihai , Koga Hironori , Torimura Takuji 
Published: February 2023

AbstractBackgroundAntiangiogenic tyrosine kinase inhibitors (TKIs) provide one of the few therapeutic options for effective treatment of hepatocellular carcinoma (HCC). However, patients with HCC often develop resistance toward antiangiogenic TKIs, and the underlying mechanisms are not understood. The aim of this study was to determine the mechanisms underlying antiangiogenic TKI resistance in HCC.MethodsWe used an unbiased proteomic approach to define proteins that were responsible for the resistance to antiangiogenic TKIs in HCC patients. We evaluated the prognosis, therapeutic response, and serum insulin‐like growth factor‐binding protein‐1 (IGFBP‐1) levels of 31 lenvatinib‐treated HCC patients. Based on the array of results, a retrospective clinical study and preclinical experiments using mouse and human hepatoma cells were conducted. Additionally, in vivo genetic and pharmacological gain‐ and loss‐of‐function experiments were performed.ResultsIn the patient cohort, IGFBP‐1 was identified as the signaling molecule with the highest expression that was inversely associated with overall survival. Mechanistically, antiangiogenic TKI treatment markedly elevated tumor IGFBP‐1 levels via the hypoxia‐hypoxia inducible factor signaling. IGFBP‐1 stimulated angiogenesis through activation of the integrin α5β1‐focal adhesion kinase pathway. Consequently, loss of IGFBP‐1 and integrin α5β1 by genetic and pharmacological approaches re‐sensitized HCC to lenvatinib treatment.ConclusionsTogether, our data shed light on mechanisms underlying acquired resistance of HCC to antiangiogenic TKIs. Antiangiogenic TKIs induced an increase of tumor IGFBP‐1, which promoted angiogenesis through activating the IGFBP‐1‐integrin α5β1 pathway. These data bolster the application of a new therapeutic concept by combining antiangiogenic TKIs with IGFBP‐1 inhibitors.
USQA: A User Story Quality Analyzer prototype for supporting software engineering students
Authors: Jiménez Samantha , Alanis Arnulfo , Beltrán Claudio , Juárez‐Ramírez Reyes , Ramírez‐Noriega Alan , Tona Claudia 
Published: February 2023

AbstractThe Standish Group Reports 83.9% of IT Projects fail, and one of the top factors in failed projects is the incomplete requirements or user stories. Therefore, it is essential to teach undergraduate students from computer science degree programs how to create complete user stories. Computer science programs include some subjects or topics involving requirements or user stories collection and writing, such as Requirements Engineering, Software Engineering, Project Management, or Quality Software Assurance. For that reason, we designed a web application called User Story Quality Analyzer (USQA) that uses Natural Language Processing modules to detect errors regarding aspects of usefulness, completeness, and polysemes in the user stories creation. The tool was proved from three perspectives: (1) a reliability test, where 35 user stories developed by experts were tested in the app to prove the prototype's reliability; (2) usability and utility analysis; 48 students interacted with the tool and responded a Satisfaction Usability Scale and an open‐ended question, the students reported a high usability score; (3) finally, error classification, we gathered 159 user stories processed by the system, and we classified the students' common errors considering incompleteness and polysemes. After the evaluations, we concluded that USQA could evaluate the user stories as an expert, which could help the professors/teachers/instructors in their courses by providing feedback to the students when they are writing user stories.
Recent advances in immunotherapy for lung cancer
Authors: Wang Qi , Su Chunxia , Zhou Caicun 
Published: February 2023

AbstractLung cancer is the malignant tumor with the highest morbidity and mortality in China, and nonsmall cell lung cancer is a common form of lung cancer. After undergoing chemotherapy and molecular targeted therapy, the treatment of lung cancer has now fully entered the era of immunotherapy. Immunotherapy‐based treatment has become one of the standard treatments for lung cancer. Immunotherapy has also gradually moved from the back line to the front line, from advanced to early patients. This article focuses on the latest developments in perioperative and advanced lung cancer immunotherapy, discusses the problems and challenges at the current stage, and explores new directions for future development.
The impact of peroxisome proliferator‐activated receptor‐γ activating angiotensin receptor blocker on outcomes of patients receiving immunotherapy
Authors: Chiang Cho‐Han , Chang Yu‐Cheng , Wang Shih‐Syuan , Chen Yuan‐Jen , See Xin Ya , Peng Chun‐Yu , Hsia Yuan Ping , Chiang Cho‐Hsien , Chiang Cho‐Hung , Peng Cheng‐Ming 
Published: February 2023

AbstractBackgroundCertain angiotensin receptor blockers (ARBs) have peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) activation property, which has been associated with improved programmed cell death ligand 1 blockade and cytotoxic T lymphocyte‐mediated antitumor activity.MethodsWe conducted a retrospective cohort study to investigate the impact of PPAR‐γ‐activating ARBs on patient survival in patients treated with immune checkpoint inhibitors (ICIs) across all types of cancers.ResultsA total of 167 patients receiving both angiotensin receptor blockers (ARBs) and immune checkpoint inhibitors (ICIs) were included. Compared with non‐PPAR‐γ‐ARB users (n = 102), PPAR‐γ‐ARB users (n = 65) had a longer median overall survival (not reached [IQR, 16.0—not reached] vs. 18.6 [IQR, 6.1–38.6] months) and progression‐free survival (17.3 [IQR, 5.1—not reached] vs. 8.2 [IQR, 2.4–18.6] months). In Cox regression analysis, the use of PPAR‐γ‐activating ARBs had an approximately 50% reduction in all‐cause mortality and disease progression. Patients who received PPAR‐γ‐activating ARBs also had higher clinical benefit rates than non‐PPAR‐γ‐ARB users (82% vs. 61%, p = 0.005).ConclusionThe use of ARBs with PPAR‐γ‐activating property is linked with better survival among patients receiving ICIs.
Framing, risk perception and social health campaigns: A neuroscientific analysis
Authors: Fernandez‐Lores Susana , Crespo‐Tejero Natividad , Fernández‐Hernández Ruth , García‐Muiña Fernando E. 
Published: February 2023

AbstractHealth authorities have widely used social health campaigns to improve the attitudes and healthy behaviours of the population. During the COVID‐19 pandemic, they became an essential tool in increasing compliance with health measures, especially among the young population, a particularly reluctant group. The aim of this study was to analyse the effectiveness of different campaigns in improving young people's intention to change their behaviour towards compliance with health measures. For this purpose, an experimental study was conducted using neurophysiological tools (electroencephalogram and galvanic skin response) as well as self‐reported data from a questionnaire. The experiment analysed three health campaigns with different narrative frames and emotions in the messages. The results showed different degrees of persuasive effectiveness depending on the framing, emotions used, and level of intensity of such emotions. Overall, it was concluded that negative framing strategies and high levels of intensity worked effectively. The influence of the perceived risk declared by the participants on the impact of the different campaigns was also analysed. In this case, for the most difficult target to activate, subjects with low perceived risk, negative and low‐intensity framing strategies were revealed to be the most effective. Implications for the design of campaigns were derived, and limitations and future lines of research were addressed.
Strategies for Synthesizing and Enhancing the Immune Response of Cancer Vaccines Based on MUC1 Glycopeptide Antigens
Authors: Yin Lixin , Zhou Yang , Hong Sheng , Ding Feiqing , Cai Hui 
Published: February 2023

AbstractCancer vaccines are based on a vaccinology strategy whereby the patient's immune system is harnessed to induce a specific immune response to kill cancer cells and comprises two categories: prophylactic and therapeutic. Glycoprotein mucin 1 (MUC1), which is overexpressed and poorly glycosylated on cancer cells, is one of the most promising candidates for the development of new cancer vaccines. However, it should be noted that mucin‐like glycopeptides are poorly immunogenic and unable to elicit effective and long‐lasting immune responses. Therefore, MUC1‐derived tumor antigens need to be conjugated with immune activators. This review focuses on the synthesis of MUC1 glycopeptides, provides an overview of recently advanced designs of vaccines based on MUC1, and compares the advantages and disadvantages of the various strategies devised to date.
Burkitt lymphoma presenting as cecum mass and spontaneous tumor lysis syndrome with hypercalcemia
Authors: Shafie Mahan , Shahmohamadi Elnaz , Ghasemi Hoomaan , Zarei Jalalabadi Narjes , Parsa Samaneh 
Published: February 2023

AbstractBurkitt's lymphoma (BL) could be primarily presented with various symptoms. We reported a woman with abdominal pain and mass who later developed spontaneous TLS with hypercalcemia, and was diagnosed with BL. Clinicians should suspect BL in case of any abdominal mass, especially with an aggressive course, to avoid further complications.
Copper‐Catalyzed Oxidative [1+2+1+2] Cascade Cyclization of N,N‐Dimethyl Enaminones with Benzylamines: A Facile Access to Functionalized 1,4‐Dihydropyridines
Authors: Sun Yulin , Chai Zhangmengjie , Liu Donghan , Zhang Mingshuai , Chen Longkun , Liu Zhuoyuan , Wang Yongchao , Yu Fuchao 
Published: February 2023

AbstractUsing benzylamines as the C4 source of 1,4‐dihydropyridines (1,4‐DHPs), a Cu‐catalyzed oxidative [1+2+1+2] cascade cyclization for the synthesis of 1,4‐DHPs was firstly developed. A broad range of easily available N,N‐dimethyl enaminones and benzylamines are employed smoothly to provide a diverse range of 1,4‐DHPs with high efficiency. This method is performed by a one‐pot cascade C(sp3)−H bond functionalization/C(sp3)−N cleavage/cyclization strategy to form simultaneously two C(sp3)−C(sp2) bonds, two C(sp2)−N bonds, and a 1,4‐DHP ring.
Single‐Molecule Measurement of Carbonic Anhydrase in Cation Coordinated Environment Using MspA Nanopore†
Authors: Song Dandan , Wang Yunjiao , Zhang Shaoxia , Zhao Lingyu , Gong Linyu , Liang Liyuan , Wang Liang 
Published: February 2023

Comprehensive SummaryCarbonic anhydrase accounts for catalytic reaction of CO2/HCO3– transformation, thus resulting in neutralization and acidification of the cellular environment, thereby favoring tumor development. Hence, it is a classical protein model of greatly biocatalytic significance as well as a highly expressed biomarker with renal tumor. We herein proposed a single‐molecule measurement on carbonic anhydrase using MspA nanopore, in [BMIM+] and asymmetric K+/Ca2+ cationic coordinated environment, instead of usual symmetric KCl/NaCl electrolyte. Significantly, our empirical analysis showed that asymmetric K+/Ca2+ cationic environment contributes to distinguishable current modulations, thus yielding better resolution for carbonic anhydrase measurement, which is independent of applied voltage and more importantly, is stable enough at varied pH conditions and for very low concentration test in urine sample. Our results provide a classical model for nanopore protein analysis, and may also permit biocatalytic measurement at single‐molecule level.
A cloud database route scheduling method using a hybrid optimization algorithm
Authors: Shokri Baghi Zahra , Jafari Navimipour Nima 
Published: February 2023

SummaryCloud computing has appeared as a technology allowing a company to employ computing resources such as applications, software, and hardware to calculate over the Internet. Scholars have paid great attention to cloud computing because of its cutting‐edge availability, cost decrement, and boundless applications. A cloud database is a data storage site on the web where the optimal path is spotted to access the needed database. So, placing the ideal path to a database is crucial. The cloud database defined the scheduling problem to choose the perfect route. Cloud database path scheduling is a multifaceted procedure consisting of congestion control, routing list, and network flow distribution. It has a postponement in searching for the needed source route from the cloud database. Offering numerous infinite resources with the growing database workload is an NP‐Hard optimization problem where the query request needs optimal schedules to respond to the required services. So, we have used a hybrid cuckoo search (CS) and genetic algorithm (GA), motivated by a social bird's phenomenon, to solve this problem. Integrating genetic operators has dramatically enhanced the balance between the capability of searching and utilization.
Transcriptomic thermal plasticity underlying gonadal development in a turtle with ZZ/ZW sex chromosomes despite canalized genotypic sex determination
Authors: Gessler Thea B. , Wu Zhiqiang , Valenzuela Nicole 
Published: February 2023

AbstractUnderstanding genome‐wide responses to environmental conditions during embryogenesis is essential for discerning the evolution of developmental plasticity and canalization, two processes generating phenotypic variation targeted by natural selection. Here, we present the first comparative trajectory analysis of matched transcriptomic developmental time series from two reptiles incubated under identical conditions, a turtle with a ZZ/ZW system of genotypic sex determination (GSD), Apalone spinifera, and a turtle with temperature‐dependent sex determination (TSD), Chrysemys picta. Results from our genome‐wide, hypervariate gene expression analysis of sexed embryos across five developmental stages revealed that substantial transcriptional plasticity in the developing gonads can persist for >145 Myr, long after the canalization of sex determination via the evolution of sex chromosomes, while some gene‐specific thermal sensitivity drifts or evolves anew. Such standing thermosensitivity represents an underappreciated evolutionary potential harbored by GSD species that may be co‐opted during future adaptive shifts in developmental programing, such as a GSD to TSD reversal, if favored by ecological conditions. Additionally, we identified novel candidate regulators of vertebrate sexual development in GSD reptiles, including sex‐determining candidate genes in a ZZ/ZW turtle.
Latitudinal variation and plasticity in response to temperature in Geukensia demissa
Authors: Erlenbach Theresa R. , Wares John P. 
Published: February 2023

AbstractAs global temperatures warm, species must adapt to a changing climate or transition to a different location suitable for their survival. Understanding the extent to which species are able to do so, particularly keystone species, is imperative to ensuring the survival of key ecosystems. The ribbed mussel Geukensia demissa is an integral part of salt marshes along the Atlantic coast of North America. Spatial patterns of genomic and phenotypic divergence have been previously documented, although their link with coastal environmental variation is unknown. Here, we study how populations of G. demissa in the northern (Massachusetts) and southern (Georgia) portions of the species range respond to changes in temperature. We combine assays of variation in oxygen consumption and RNA transcriptomic data with genomic divergence analyses to identify how separate populations of G. demissa may vary in distinct thermal environments. Our results show differences in constitutive oxygen consumption between mussels from Georgia and Massachusetts, as well as shared and disparate patterns of gene expression across temperature profiles. We also find that metabolic genes seem to be a strong component of divergence between these two populations. Our analysis highlights the importance of studying integrative patterns of genomic and phenotypic variation in species that are key for particular ecosystems, and how they might respond to further changes in climate.
The interaction between physical frailty and prognostic impact of heart failure medication in elderly patients
Authors: Abe Takuro , Jujo Kentaro , Maeda Daichi , Saito Katsumi , Ogasahara Yuki , Saito Kazuya , Saito Hiroshi , Iwata Kentaro , Konishi Masaaki , Kitai Takeshi , Kasai Takatoshi , Wada Hiroshi , Momomura Shin‐ichi , Kagiyama Nobuyuki , Kamiya Kentaro , Yamashita Masashi , Hamazaki Nobuaki , Nozaki Kohei , Maekawa Emi , Ako Junya , Matsue Yuya 
Published: February 2023

AbstractAimsFrailty is highly prevalent and associated with poor prognoses in elderly patients with heart failure (HF). However, the potential effects of physical frailty on the benefits of HF medications in elderly patients with HF are unclear. We aimed to determine the influence of physical frailty on the prognosis of HF medications in elderly patients with HF with reduced and mildly reduced ejection fraction (HFr/mrEF).Methods and resultsFrom the combined HF database of the FRAGILE‐HF and Kitasato cohorts, hospitalized HF patients with a left ventricular ejection fraction < 50% and age ≥ 65 years were analysed. Patients treated with or without renin‐angiotensin‐aldosterone system inhibitors (RAASi) and beta‐blockers at discharge were compared. Physical frailty was defined by the presence of ≥3 items on the Japanese version of the Cardiovascular Health Study criteria. The primary endpoint was all‐cause mortality rate. Among the 1021 enrolled patients, 604 patients (59%) received both RAASi and beta‐blockers, and 604 patients (59%) were diagnosed as physically frail. Patients receiving both RAASi and beta‐blockers showed a significantly lower 1 year mortality than those not receiving either, even after adjusting for covariates (hazard ratio: 0.50, 95% confidence interval: 0.34–0.75). This beneficial effect of both medications on 1 year mortality was comparable between patients with and without physical frailty (hazard ratio: 0.53 and 0.51, respectively; P for interaction = 0.77).ConclusionsThe presence of physical frailty did not interact with the beneficial prognostic impact of RAASi and beta‐blocker combination therapy in elderly patients with HFr/mrEF.
Association between serum albumin and outcomes in heart failure and secondary mitral regurgitation: the COAPT trial
Authors: Feng Kent Y. , Ambrosy Andrew P. , Zhou Zhipeng , Li Ditian , Kong Jeremy , Zaroff Jonathan G. , Mishell Jacob M. , Ku Ivy A. , Scotti Andrea , Coisne Augustin , Redfors Björn , Mack Michael J. , Abraham William T. , Lindenfeld JoAnn , Stone Gregg W. ,   COAPT Trial Investigators
Published: February 2023

ABSTRACTAimsLow serum albumin levels are associated with poor prognosis in numerous chronic disease states but the relationship between albumin and outcomes in patients with heart failure (HF) and secondary mitral regurgitation (SMR) has not been described.Methods and resultsThe randomized COAPT trial evaluated the safety and effectiveness of transcatheter edge‐to‐edge repair (TEER) with the MitraClipTM plus guideline‐directed medical therapy (GDMT) versus GDMT alone in patients with symptomatic HF and moderate‐to‐severe or severe SMR. Baseline serum albumin levels were measured at enrolment. Among 614 patients enrolled in COAPT, 559 (91.0%) had available baseline serum albumin levels (median 4.0 g/dl, interquartile range 3.7–4.2 g/dl). Patients with albumin <4.0 g/dl compared with ≥4.0 g/dl were older and more likely to have ischaemic cardiomyopathy and a hospitalization within the year prior to enrolment. After multivariable adjustment, patients with albumin <4.0 g/dl had higher 4‐year rates of all‐cause death (63.7% vs. 47.6%; adjusted hazard ratio 1.34, 95% confidence interval 1.02–1.74; p = 0.032), but there were no significant differences in HF hospitalizations (HFH) or all‐cause hospitalizations according to baseline serum albumin level. The relative effectiveness of TEER plus GDMT versus GDMT alone was consistent in patients with low and high albumin levels (pinteraction = 0.19 and 0.35 for death and HFH, respectively).ConclusionLow baseline serum albumin levels were independently associated with reduced 4‐year survival in patients with HF and severe SMR enrolled in the COAPT trial, but not with HFH. Patients treated with TEER derived similarly robust reductions in both death and HFH regardless of baseline albumin level.
Enantioselective Desymmetrization of Curcumins with 3‐Olefinic Oxindoles for the Synthesis of Spirocyclohexanoneoxindoles
Authors: Siva Sankara Chenikkayala , Bhagat Shweta , Chandra Ajeet , Namboothiri Irishi N. N. 
Published: February 2023

AbstractAn enantioselective desymmetrization of curcumins with 3‐olefinic oxindoles involving a cascade double‐Michael addition strategy provides direct access to spirocyclohexanone‐oxindoles with complete regio‐ and diastereoselectivities and excellent enantioselectivities, besides good to excellent yields. The products possess three contiguous chiral centers and multiple reactive functionalities. The observed selectivities were rationalized by transitions state energy calculations at B3LYP//6‐31g(d) level of DFT.