bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of economic status on metabolic control in type 2 diabetes mellitus at 10 metabolic management centers in China
Authors: Gu Liping , Ma Yuhang , Zheng Qidong , Gu Weiqiong , Ke Tingyu , Li Li , Zhao Dong , Dai Yuancheng , Dong Qijuan , Ji Bangqun , Xu Fengmei , Shi Juan , Peng Ying , Zhang Yifei , Shen Tingting , Du Rui , Yang Jiaying , Kang Mei , Peng Yongde , Wang Yufan , Wang Weiqing 
Published: September 2023

AbstractObjectiveThis study investigated the association of economic status with metabolic index control in type 2 diabetes mellitus (T2DM) patients.MethodsIn total, 37 454 T2DM patients from 10 National Metabolic Management Centers in China were recruited and categorized into two groups: a high‐gross domestic product (GDP) group (n = 23 993) and a low‐GDP group (n = 13 461). Sociodemographic characteristics, medical histories, and lifestyle factors were recorded. Logistic regression and interaction analysis were performed to evaluate the association of economic status and healthy lifestyle with metabolic control.ResultsCompared to the low‐GDP group, there were fewer patients with glycated hemoglobin (HbA1c) levels ≥7% in the high‐GDP group. Fewer patients with a high GDP had an abnormal metabolic state (HbA1c ≥ 7%, blood pressure [BP] ≥130/80 mm Hg, total cholesterol [TCH] ≥4.5 mmol/L or body mass index [BMI] ≥24 kg/m2). The risks of developing HbA1c ≥ 7% (odds ratios [OR] = 0.545 [95% CI: 0.515–0.577], p < .001), BP ≥ 130/80 mm Hg (OR = 0.808 [95% CI: 0.770–0.849], p < .001), BMI ≥ 24 kg/m2 (OR = 0.840 [95% CI: 0.799–0.884], p < .001), and an abnormal metabolic state (OR = 0.533 [95% CI: 0.444–0.636], p < .001) were significantly lower in the high‐GDP group even after adjustment for confounding factors. Younger participants; those with a family history of diabetes, normal weight, and a physical activity level up to standard; and those who did not drink alcohol in the high‐GDP group were predisposed to better glycemic levels.ConclusionsT2DM patients in economically developed regions had better metabolic control, especially glycemic control. A healthy lifestyle had an additive effect on achieving glycemic goals, even among high‐GDP patients.
N6‐methyladenosine‐modified circFUT8 competitively interacts with YTHDF2 and miR‐186‐5p to stabilize FUT8 mRNA to promote malignant progression in lung adenocarcinoma
Authors: Dong Gaochao , Liang Yingkuan , Chen Bing , Zhang Te , Wang Hui , Chen Yuzhong , Zhang Yijian , Jiang Feng , Wang Yaping 
Published: September 2023

AbstractBackgroundLung cancer is the leading cause of cancer related to mortality worldwide, and the main pathological type is lung adenocarcinoma (LUAD). Circular RNAs (circRNAs) have been reported to be modified by N6‐methyladenosine (m6A), which is involved in the progression of diverse tumors. However, the crosstalk between circRNAs and m6A modification has not been well elucidated in LUAD.MethodsMeRIP‐seq and YTHDF2‐RIP‐seq datasets were explored to identify candidate circRNAs modified by YTHDF2. Dual‐luciferase reporter assay, RIP, and rescue assays were performed to explore the relationship between circFUT8 and its parent mRNA of FUT8. In vitro and in vivo experiments were utilized to uncover the function of circFUT8.ResultsIn this study, we identified a novel m6A‐modified circFUT8, derived from exon 3 of FUT8, which was elevated in tumor tissues compared with adjacent noncancerous tissues. The m6A reader YTHDF2 recognized and destabilized circFUT8 in an m6A‐dependent manner. YTHDF2 also combined with the line form of FUT8 (mFUT8), and circFUT8 competitively interacted with YTHDF2, blunting its binding to mFUT8, to stabilize the mRNA level of FUT8. Additionally, circFUT8 sponged miR‐186‐5p to elevate the expression of mFUT8. Finally, we revealed that circFUT8 promoted the malignant progression of LUAD dependent on the oncogenic function of FUT8.ConclusionsThese findings identified a novel m6A‐modified circFUT8 recognized and destabilized by YTHDF2, which competitively interacted with YTHDF2 and miR‐186‐5p to stabilize FUT8 mRNA to promote malignant progression in LUAD.
Pretreatment eosinophil counts as a predictive biomarker in non‐small cell lung cancer patients treated with immune checkpoint inhibitors
Authors: Takeuchi Eiji , Kondo Kensuke , Okano Yoshio , Ichihara Seiya , Kunishige Michihiro , Kadota Naoki , Machida Hisanori , Hatakeyama Nobuo , Naruse Keishi , Ogino Hirokazu , Nokihara Hiroshi , Shinohara Tsutomu , Nishioka Yasuhiko 
Published: September 2023

AbstractBackgroundThe peripheral blood eosinophil count prior to treatment has potential as a predictive biomarker for a beneficial clinical response to cancer immunotherapies. Therefore, the present study investigated the impact of the eosinophil count on overall survival (OS) in non‐small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICI).MethodsWe retrospectively reviewed all patients diagnosed with NSCLC and treated with ICI monotherapy between March 2016 and August 2021 at National Hospital Organization Kochi Hospital and Tokushima University.ResultsA total of 166 patients were included. Fifty‐five patients had an eosinophil count of less than 100 cells/μL (Eo < 100). Nighty‐eight patients had an eosinophil count of 100 cells/μL or more, but less than 500 cells/μL (100 ≤ Eo < 500). Thirteen patients had an eosinophil count of 500 cells/μL or more (Eo ≥500). The median OS of all lung cancer patients was 476 days. The median OS of lung cancer patients with Eo <100, 100 ≤ Eo <500, and Eo ≥500 was 339, 667, and 143 days, respectively. A Kaplan–Meier univariate analysis showed a significant difference in OS between these three groups (p < 0.001). A Cox proportional regression analysis identified 100 ≤ Eo <500 (p = 0.04), ECOG PS score ≥ 2 (p = 0.02), tumor size ≥5 cm (p = 0.02), and PD‐L1 ≥ 1% (p = 0.01) as independent predictors of OS.ConclusionOS was significantly longer in ICI‐treated NSCLC patients with a pretreatment eosinophil count of 100 ≤ Eo <500 than in the other patients and, thus, has potential as a new predictive biomarker.
Analysis of the brain transcriptome for substance‐associated genes: An update on large‐scale genome‐wide association studies
Authors: Zhao Yihong , Han Xuewei , Zheng Zhi‐Liang 
Published: September 2023

AbstractSubstance use disorder (SUD) arises from the initiation to subsequent regular, irregular and harmful use of substances such as alcohol, tobacco/nicotine and cannabis. While thousands of genetic variants have been identified from recent large‐scale genome‐wide association studies (GWAS), understanding their functions in substance involvement and investigating the mechanisms by which they act in the addiction circuits remains challenging. In this study, we re‐analysed the brain regional transcriptome data from the most comprehensive postmortem transcriptomic study, with a focus on up‐ or down‐regulation of substance‐associated protein‐coding genes in the addiction circuit‐related brain regions (AddictRegions), including six cortical and 11 subcortical regions. We found that substance‐associated genes were overrepresented in AddictRegions. Interestingly, we observed a greater degree of genetic overlap between initiation and use and between use and SUD than between initiation and SUD. Moreover, substance initiation, use and SUD‐associated genes tend to shift their enriched AddictRegions from the cortical for initiation and, to a lesser extent, substance use to subcortical regions for SUD (e.g., thalamus, substantia nigra and ventral tegmental area). We also uncovered a pattern of coordinated cortical up‐regulation and subcortical down‐regulation for the genes associated with tobacco initiation and alcohol use. Moreover, the Gene Ontology terms of glutamate receptor activity and neurotransmitter binding were most significantly overrepresented in AddictRegion‐upregulated, substance‐associated genes, with the strongest enrichment for those involved in common substance use behaviours. Overall, our analysis provides a resource of AddictRegion‐related transcriptomes for studying substance‐associated genes and generates intriguing insights into the genetic control of substance initiation, use and SUD.
Youth participation processes in longitudinal out of home care research
Authors: Walter Brontё , Parsons Lauren , Croghan Casey , Chung Donna 
Published: September 2023

AbstractWhile there is growing recognition of the importance of meaningful youth participation in activities and decisions which impact their lives, facilitating such engagement within different forums requires varied approaches. A programme of youth research at one Western Australian university has sought to embed pathways for ongoing youth participation in longitudinal research. In particular, we discuss Navigating Through Life, a large‐scale WA research project comprising three sub‐studies exploring young people's transitions from out of home care (OOHC) to independence. We established a youth advisory group to run alongside the project and employed peer researchers to conduct research tasks. In this paper, we seek to explicate the development and various iterations of youth participation in the project. We utilise our reflections, interview data and documentation from YAG meetings and feedback sessions with the peer researchers to illustrate the processes of transformation and flexibility required to develop and maintain youth participation in various ways across the project's life. Drawing on our findings and current literature, we highlight how funding bodies and researchers must consider the additional needs, unique and changeable life circumstances of young people to best facilitate their involvement in research.
Hyper‐CVAD versus dose‐adjusted EPOCH as initial treatment for adults with acute lymphoblastic leukemia
Authors: Zarling Lucas C. , Stevenson Philip A. , Soma Lorinda A. , Martino Christen H. , Percival Mary‐Elizabeth M. , Halpern Anna B. , Ghiuzeli Cristina M. , Becker Pamela S. , Oehler Vivian G. , Cooper Jason P. , Orozco Johnnie J. , Hendrie Paul C. , Walter Roland B. , Estey Elihu H. , Cassaday Ryan D. 
Published: September 2023

AbstractObjectivesWe recently performed a single‐arm phase II trial of DA‐EPOCH in adults with acute lymphoblastic leukemia (ALL). We sought to compare these results to those with standard Hyper‐CVAD.MethodsWe created a retrospective matched cohort of patients who received Hyper‐CVAD (n = 69) at our center and otherwise met eligibility criteria for the DA‐EPOCH trial (n = 53).ResultsOur outcomes support the use of Hyper‐CVAD over DA‐EPOCH in Ph− disease for both overall survival (OS; HR 0.18, p = .004) and event‐free survival (EFS; HR 0.51, p = .06). In contrast, outcomes were similar in Ph+ disease (OS HR 0.97, p = .96; EFS HR 0.65, p = .21). Rates of morphologic remission and measurable residual‐disease negativity were similar between the regimens. Hyper‐CVAD was associated with significantly more febrile neutropenia (OR 1.9, p = .03) and a greater incidence of Grade 4 or 5 adverse events (20% vs. 6%). Average transfusions per cycle of both red blood cells (p < .001) and platelets (p < .001) were five‐fold higher with Hyper‐CVAD.ConclusionsOur findings support continued use of Hyper‐CVAD for Ph− ALL but suggest that DA‐EPOCH may be a reasonable alternative for Ph+ ALL. These data also highlight a potential role for DA‐EPOCH in resource‐limited settings or when more intense therapy is not feasible.
Enhanced efficacy of CD19/CD22 bispecific CAR‐T cells with EAAAK linker on B‐cell malignancies
Authors: Ma Renyuxue , You Fengtao , Tian Shuaiyu , Zhang Tingting , Tian Xiaopeng , Xiang Shufen , Wu Hai , Yang Nan , An Gangli , Yang Lin 
Published: September 2023

AbstractObjectivesDespite the great success of CD19 CAR‐T cell therapy, its clinical efficacy has been greatly hampered by the high relapse rate. In this study, we designed and compared four structures of CD19/CD22 bispecific CAR‐T cells with different linkers and different orders of the antibody sequences.MethodsWe detected the cytotoxicity, cytokine secretion levels, sustainable killing ability, differentiation, exhaustion of these four CAR‐T cells in vitro. The optimal Bis‐C CAR‐T cells were evaluated the efficacy using NSG mice.ResultsThe two structures of CD19/CD22 bispecific CAR‐T cells using (EAAAK)3 as linker had more significant cytotoxicity and cytokine secretion levels. In the process of continuous killing, Bis‐C CAR‐T cells showed better sustained killing ability, memory phenotype differentiation, and exhaustion. In the in vivo experiment mimicking CD19‐negative relapse, Bis‐C CAR‐T was more able to control the tumor progression of mice in the CD19 low expression or no expression groups than CD19 CAR‐T.ConclusionsThis study has generated a novel bispecific CAR‐T cell that can simultaneously target CD19 or CD22 positive tumor cells, providing a new strategy to address the limitations of single‐targeted CAR‐T therapy in B‐cell tumors (limited response or relapse).
Species trait diversity sustains multiple dietary nutrients supplied by freshwater fisheries
Authors: Heilpern Sebastian A. , Herrera‐R Guido A. , Fiorella Kathryn J. , Moya Luis , Flecker Alexander S. , McIntyre Peter B. 
Published: September 2023

AbstractSpecies, through their traits, influence how ecosystems simultaneously sustain multiple functions. However, it is unclear how trait diversity sustains the multiple contributions biodiversity makes to people. Freshwater fisheries nourish hundreds of millions of people globally, but overharvesting and river fragmentation are increasingly affecting catches. We analyse how loss of nutritional trait diversity in consumed fish portfolios affects the simultaneous provisioning of six essential dietary nutrients using household data from the Amazon and Tonlé Sap, two of Earth's most productive and diverse freshwater fisheries. We find that fish portfolios with high trait diversity meet higher thresholds of required daily intakes for a greater variety of nutrients with less fish biomass. This beneficial biodiversity effect is driven by low redundancy in species nutrient content profiles. Our findings imply that sustaining the dietary contributions fish make to people given declining biodiversity could require more biomass and ultimately exacerbate fishing pressure in already‐stressed ecosystems.
Hidden black and yellow thigh color acts as an aposematic signal in the Eastern Gray Treefrog (Hyla versicolor)
Authors: Cannizzaro Joseph S. , Höbel Gerlinde 
Published: September 2023

AbstractRecognizing form and function of animal defenses is paramount to understanding the ecological and evolutionary forces behind predator and prey dynamics. Color patterns are strongly related to defensive strategies in animals. Some rely on camouflage to avoid detection, while others are brightly colored and conspicuously signal their noxiousness to potential predators. Still others combine cryptic dorsal coloration with colorful patches that are concealed in resting position but are facultatively unveiled by special behavior or simply during activity. Such hidden conspicuous color patches may be an intermediate stage in the evolution from camouflage to aposematism. Many species, especially treefrogs of the family Hylidae, are generally considered to be cryptic, yet show colorful patches on their flanks or thighs and have defensive skin secretions that may have unpalatable properties. We investigated whether the conspicuous black and yellow spotted pattern on the thighs of Eastern Gray Treefrogs (Hyla versicolor) serve as an aposematic signal. We conducted a palatability study to test whether Gray Treefrog skin secretions are unpalatable, and a clay model field study to test whether the conspicuous black and yellow thigh pattern is an aposematic warning coloration that reduces predation. Frog secretions were discriminated against during palatability assays, and clay models painted with a spotted black and yellow pattern suffered lower predation rates. Our findings support the hypothesis that hidden color patches act as aposematic signals in Gray Treefrogs and suggest that more species benefit from aposematic coloration than currently appreciated.
Fine‐scale environmentally associated spatial structure of lumpfish (Cyclopterus lumpus) across the Northwest Atlantic
Authors: Langille Barbara L. , Kess Tony , Brachmann Matthew , Nugent Cameron M. , Messmer Amber , Duffy Steven J. , Holborn Melissa K. , Van Wyngaarden Mallory , Knutsen Tim Martin , Kent Matthew , Boyce Danny , Gregory Robert S. , Gauthier Johanne , Fairchild Elizabeth A. , Pietrak Michael , Eddy Stephen , de Leaniz Carlos Garcia , Consuegra Sofia , Whittaker Ben , Bentzen Paul , Bradbury Ian R. 
Published: September 2023

AbstractLumpfish,Cyclopterus lumpus, have historically been harvested throughout Atlantic Canada and are increasingly in demand as a solution to controlling sea lice in Atlantic salmon farms—a process which involves both the domestication and the transfer of lumpfish between geographic regions. At present, little is known regarding population structure and diversity of wild lumpfish in Atlantic Canada, limiting attempts to assess the potential impacts of escaped lumpfish individuals from salmon pens on currently at‐risk wild populations. Here, we characterize the spatial population structure and genomic‐environmental associations of wild populations of lumpfish throughout the Northwest Atlantic using both 70K SNP array data and whole‐genome re‐sequencing data (WGS). At broad spatial scales, our results reveal a large environmentally associated genetic break between the southern populations (Gulf of Maine and Bay of Fundy) and northern populations (Newfoundland and the Gulf of St. Lawrence), linked to variation in ocean temperature and ice cover. At finer spatial scales, evidence of population structure was also evident in a distinct coastal group in Newfoundland and significant isolation by distance across the northern region. Both evidence of consistent environmental associations and elevated genome‐wide variation inFSTvalues among these three regional groups supports their biological relevance. This study represents the first extensive description of population structure of lumpfish in Atlantic Canada, revealing evidence of broad and fine geographic scale environmentally associated genomic diversity. Our results will facilitate the commercial use of lumpfish as a cleaner fish in Atlantic salmon aquaculture, the identification of lumpfish escapees, and the delineation of conservation units of this at‐risk species throughout Atlantic Canada.
Extubation failure and surgical removal of a lodged endotracheal tube in a Welsh Mountain Pony
Authors: Libera Natalia , Barnes Hattie K. , Senior J. Mark 
Published: September 2023

SummaryComplications related to endotracheal intubation are well recognised in both human and veterinary medicine; however, difficult extubation is rare and is typically related to accidental physical fixation, inability to deflate the cuff, anatomical abnormalities or an inappropriate tube. In this case report we describe an unexpected failure to extubate where tracheotomy was required to facilitate the removal of the endotracheal tube in an adult pony.
The use of emotionally focused therapy with polyamorous relationships
Authors: Edwards Caitlin , Allan Robert , Marzo Nick , Wynfield Ted , Hicks Ryan 
Published: September 2023

AbstractApproximately 5% of people in the United States engage in some form of consensual non‐monogamy (CNM;Archives of Sexual Behavior, 2018, 47, 1439). Therapists are becoming increasingly aware of the need to treat members of CNM relationships, including polyamorous relationships. To date, no research has been conducted and little has been written about applying existing couple therapy models normed on heterosexual, cisgender, monogamous relationships to CNM or polyamorous relationships. Emotionally focused therapy (EFT) is an empirically supported treatment for relationship distress that offers promise for working with polyamorous relationships due to the model's systemic and attachment theoretical foundations. We propose EFT is an ideal model for working with polyamorous relationships because of the focus on externalizing, interpersonal and intrapersonal emotional and experiential coherence, and the attachment bond. Building and sustaining multiple attachment relationships allows for the fulfilment of a diverse range of relational needs and wants as well as provides a secure base for individual and relational exploration. In this article, we first provide general information about polyamory and discuss the research on attachment theory and polyamory. We then provide a step‐by‐step conceptualization of how EFT therapists can expand the model to include extra‐dyadic attachment relationships. In addition, we include specific ways in which the model would need to be adapted when working with polyamorous clients. We conclude with recommendations for EFT therapists working with polyamorous relationships.
Identifying and managing evaluator biases in parenting plan evaluations
Authors: Davis Lindsey Sank , Stahl Philip M. 
Published: September 2023

AbstractPsychologists and other professionals are often appointed by the courts to assist families in resolving post‐separation disputes and to assist judges in making orders on behalf of the best interests of the child(ren). Although these evaluations provide valuable information to the court, they require assessing areas of human behavior that are imprecisely defined or lacking professional consensus. As parents separate, their disputes may become more challenging, and they may act in uncharacteristic and unpredictable ways. Families that cannot solve their own challenges outside of court often show high levels of conflict and/or have issues that are extremely complex, including domestic violence allegations, resist‐refuse family dynamics, and relocation requests. Evaluators and judges, being human, tend to oversimplify complex issues due to the limitations of the human brain. Evaluators are subject to cognitive biases that result from the use of mental heuristics, leading to shortcuts and errors in their reasoning and judgment. Other biases, such as implicit and explicit cultural biases, often influence evaluators' reasoning and conclusions. This article explores various biases that affect and potentially diminish the quality of an evaluator's work. We conclude by addressing “de‐biasing” strategies that can reduce, but not negate, the risks associated with such biases.
Models and methods of cost‐effective child custody evaluation
Authors: Robb Aaron 
Published: September 2023

AbstractChild custody evaluations (CCEs) are often seen as a necessity by the legal system when caregivers cannot find a resolution to their child custody disputes. In many instances, these evaluations are quite costly for the litigants and cost can act as a barrier to equal access to justice. Affluent families are better able to access private evaluators while families with lesser means may encounter delays in receiving services or be unable to afford an evaluation at all. This can, in turn, prolong resolution of league disputes, increasing the emotional toll on families, and hamper courts in making decisions in the best interests of the children involved. This article examines models of providing CCEs outside of an isolated individual provider private practice format. It examines the benefits and considerations for lower‐cost evaluations, while discussing how to maintain high quality services that adequately assess family systems. Broader issues that impact the courts and overall access to justice through offering cost effective evaluations are also discussed.