bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal Morphine Exposure Increases Cardiovascular Disease Risk and Programs Neurogenic Hypertension in the Adult Offspring
Authors: Ahmed Nermin , Kassis Alana , Malone Jena , Yang Jodie , Zamzami Esraa , Lin An-Hsuan , Gordon Scott M. , Gong Ming C. , Bardo Michael , Dalmasso Carolina , Loria Analia S. 
Published: April 2023

Background:
The opioid overdose and opioid use disorder epidemics are concomitant with increased metabolic and CVD risk. Although opioid use disorder causes adverse pregnancy outcomes, the offspring’s cardiovascular health is understudied. We hypothesized that offspring exposed to in utero morphine exposure (IUME) would show increased CVD risk factors and endogenous opioid system dysregulation.

Methods:
Sprague Dawley dams were treated with saline (vehicle, n=10) or escalating doses of morphine (5–20 mg/kg per day, SC, n=10) during gestation. Cardiovascular and metabolic parameters were assessed in adult offspring.

Results:

Litter size and pups’ birth weight were not different in response to IUME. Female and male IUME offspring showed reduced body length at birth (
P
<0.05) and body weight from weeks 1 to 3 of life (
P
<0.05), followed by a catch-up growth effect. By week 16, female and male IUME rats showed reduced tibia length (
P
<0.05) and fat mass. IUME increases the mean arterial pressure and the depressor response to mecamylamine (5 mg/kg per day, IP) induced by IUME were abolished by a chronic treatment with an alpha-adrenergic receptor blocker (prazosin; 1 mg/kg per day, IP). Although circulating levels of angiotensin peptides were similar between groups, IUME exacerbated maximal ex vivo Ang (angiotensin) II–induced vasoconstriction (
P
<0.05) and induced endothelial dysfunction in a sex-specific manner (
P
<0.05). Proenkephalin, an endogenous opioid peptide that lowers blood pressure and sympathetic-mediated vasoconstriction, showed reduced mRNA expression in the heart, aorta, and kidneys from morphine versus vehicle group (
P
<0.05).

Conclusions:
Among the effects of IUME, neurogenic hypertension, vascular dysfunction, and metabolic dysfunction could be associated with the dysregulation of the endogenous opioid system.
Association of Clinical Outcomes With Sex in Patients Receiving Chronic Maintenance Antiplatelet Monotherapy After Percutaneous Coronary Intervention: A Post Hoc Gender Analysis of the HOST‐EXAM Study
Authors: Shin Eun‐Seok , Jun Eun Jung , Kim Bitna , Won Ki‐Bum , Koo Bon‐Kwon , Kang Jeehoon , Park Kyung Woo , Rhee Tae‐Min , Yang Han‐Mo , Han Jung‐Kyu , Kim Hyo‐Soo ,   the HOST‐EXAM Investigators
Published: April 2023

Background
Clopidogrel monotherapy was more effective in reducing the risk of adverse clinical events than aspirin monotherapy in patients who underwent percutaneous coronary intervention (PCI) with drug‐eluting stent (DES), according to the HOST‐EXAM (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis–Extended Antiplatelet Monotherapy) trial. However, it remains unknown whether these effects differ based on sex.

Methods and Results

This was a prespecified secondary analysis of HOST‐EXAM in South Korea. Patients who maintained dual antiplatelet therapy without adverse clinical events for 6 to 18 months after PCI with DES were included. The primary end point was a composite of all‐cause mortality, nonfatal myocardial infarction, stroke, acute coronary syndrome, or Bleeding Academic Research Consortium (BARC) bleeding type ≥3 at 24 months after randomization. The bleeding end point was BARC types 2 to 5. The primary end point was comparable between the sexes (adjusted hazard ratio [HR], 0.79 [95% CI, 0.62–1.02];
P
=0.067), and the bleeding end point (adjusted HR, 0.79 [95% CI, 0.54–1.17];
P
=0.240) was also similar. Compared with aspirin, clopidogrel was associated with lower risk of primary composite end point (adjusted HR, 0.70 [95% CI, 0.55–0.89];
P
=0.004) and bleeding end point (adjusted HR, 0.65 [95% CI, 0.44–0.96];
P
=0.031) in men but not in women.

Conclusions
The primary composite end point and bleeding events were comparable between the sexes during chronic maintenance antiplatelet monotherapy after PCI with DES. Clopidogrel monotherapy, compared with aspirin, significantly reduced the risk of the primary composite end point and bleeding events in men. However, the beneficial effect of clopidogrel on the primary end point and bleeding events was mitigated in women.

Registration Information

clinicaltrials.gov
. Identifier: NCT02044250.
Risk Factors for Mortality From Aortic Aneurysm and Dissection: Results From a 26‐Year Follow‐Up of a Community‐Based Population
Authors: Koba Ai , Yamagishi Kazumasa , Sairenchi Toshimi , Noda Hiroyuki , Irie Fujiko , Takizawa Nobue , Tomizawa Takuji , Iso Hiroyasu , Ota Hitoshi 
Published: April 2023

Background
Aortic aneurysm rupture and acute aortic dissection are life‐threatening conditions and represent an ever‐growing public health challenge. Comprehensive epidemiologic investigations for their risk factors are scant. We aimed to investigate risk factors associated with mortality from aortic diseases through analysis of a community‐based Japanese cohort.

Methods and Results
IPHS (Ibaraki Prefectural Health Study) comprises 95 723 participants who took part in municipal health checkups in 1993. Factors considered for analysis included age, sex, body mass index, blood pressure, serum lipids (high‐density lipoprotein [HDL] cholesterol, non‐HDL cholesterol, and triglycerides), diabetes, antihypertensive and lipid‐lowering drug use, and smoking and drinking habits. Cox proportional hazards models were applied to evaluate the associations between these variables and mortality from aortic diseases. During the median 26‐year follow‐up, 190 participants died of aortic aneurysm rupture, and 188 died of aortic dissection. An increased multivariable hazard ratio (HR) for mortality from total aortic diseases was observed for high systolic blood pressure (1.61 [1.00–2.59]), diastolic blood pressure (2.95 [1.95–4.48]), high non‐HDL cholesterol (1.63 [1.19–2.24]), low HDL cholesterol (1.86 [1.29–2.68]), and heavy (>20 cigarettes/day) smoking habit (2.46 [1.66–3.63]). A lower multivariable HR was observed for diabetes (0.50 [0.28–0.89]).

Conclusions
Smoking habit, higher systolic blood pressure and diastolic blood pressure levels, higher non‐HDL, and lower HDL cholesterol levels were positively associated with mortality from total aortic diseases, whereas diabetes was inversely associated.
Resolving inter-regional communication capacity in the human connectome
Authors: Milisav Filip , Bazinet Vincent , Iturria-Medina Yasser , Misic Bratislav 
Published: April 2023

Abstract
Applications of graph theory to the connectome have inspired several models of how neural signaling unfolds atop its structure. Analytic measures derived from these communication models have mainly been used to extract global characteristics of brain networks, obscuring potentially informative inter-regional relationships. Here we develop a simple standardization method to investigate polysynaptic communication pathways between pairs of cortical regions. This procedure allows us to determine which pairs of nodes are topologically closer and which are further than expected on the basis of their degree. We find that communication pathways delineate canonical functional systems. Relating nodal communication capacity to meta-analytic probabilistic patterns of functional specialization, we also show that areas that are most closely integrated within the network are associated with higher order cognitive functions. We find that these regions’ proclivity towards functional integration could naturally arise from the brain’s anatomical configuration through evenly distributed connections among multiple specialized communities. Throughout, we consider two increasingly constrained null models to disentangle the effects of the network’s topology from those passively endowed by spatial embedding. Altogether, the present findings uncover relationships between polysynaptic communication pathways and the brain’s functional organization across multiple topological levels of analysis and demonstrate that network integration facilitates cognitive integration.
The Use and Plagiarism of Descartes’s Traité de l’homme by Henricus Regius: A Reassessment
Authors: Strazzoni Andrea 
Published: April 2023

Abstract
In this article I discuss a particular aspect of the Dutch reception of the ideas of René Descartes, namely the use of his Traité de l’homme by Henricus Regius. I analyze the use that Regius made of the theory of the movement of muscles, passions, hunger, and more generally of the neurophysiology expounded by Descartes in his book (not printed until 1662–1664). In my analysis, I reconstruct the internal evolution of Regius’s neurophysiology, I illustrate its sources beyond Descartes (i.e., Jean Fernel and Santorio Santorio), and I show that he was certainly acquainted with some of its contents as early as 1641 (when he used it with the mediation of Descartes), before relying on it—as variously discussed in secondary literature—in his Fundamenta physices (1646), when he appropriated from it without Descartes’s authorization.
Phylogeny and classification of Nesobasis Selys, 1891 and Vanuatubasis Ober & Staniczek, 2009 (Odonata: Coenagrionidae)
Authors: Ferguson Daniel G. , Marinov Milen , Saxton Natalie A. , Rashni Bindiya , Bybee Seth M. 
Published: April 2023

Abstract
Island archipelagos in the South Pacific have relatively high species endemism within the insect order Odonata, specifically damselflies. Nesobasis Selys, 1891, an endemic damselfly genus from Fiji, includes over 20 species, but a clear understanding of its evolutionary relationship to other damselflies in the region is lacking. Scientists have questioned the monophyly of Nesobasis due to variations within the genus leading to the establishment of three divisions provisionally named as: comosa-, erythrops- and longistyla- groups. However, Nesobasis has shown to be monophyletic in previous phylogenetic analyses. Using additional species in this study, we investigate the phylogenetic relationships between Nesobasis and other damselflies from the region, specifically the endemic Vanuatubasis Ober & Staniczek, 2009 from the neighboring island archipelagos of Vanuatu. The relationship between these taxa has not yet been examined with molecular data. Five genes were used in a maximum likelihood phylogenetic reconstruction and examined morphological data to determine the relationship between these genera. Our results recover three distinct clades overall with Vanuatubasis nested within Nesobasis (i.e., non-monophyletic). Vanuatubasis is sister to the longistyla and erythrops groups. The third group, comosa, was found sister to the clade of Vanuatubasis (longistyla + erythrops). As a result of these findings, we propose the new genus, Nikoulabasis gen. nov.
The Library of Eugen Mittwoch (1876–1942)
Authors: Schmidtke Sabine 
Published: April 2023

Abstract
Eugen Mittwoch (1876–1942) was one of the most prominent representatives of German Orientalism during the first decades of the twentieth century. Trained as an Arabist and Semitist, Mittwoch was at the same time a specialist of Ethiopian studies, and he was part of the circle of Carl Heinrich Becker (1876–1933) who initiated a new direction for Islamic studies in Orientalism. At the same time, Mittwoch was also engaged in the study of the Geniza and he worked on topics relevant to the Science of Judaism (“Wissenschaft des Judentums”). Mittwoch’s academic career ended abruptly when he was dismissed from his professorial position at the end of 1935 and eventually forced into exile in 1938. As a result, only portions of his professional and personal Nachlass have come to us. The present study provides a first overview of the available sources for a reconstruction of his biography and it discusses in some depth those that inform us of the fate of his library, in 1939, when his family joined him in London, as well as after his death in 1942.
Vocalizing a Eurasian Otherness: Antony Firingi and a Creole Bengali Subalternity
Authors: Sil Esha 
Published: April 2023

Abstract
This paper examines the alternative articulations of the nineteenth-century Eurasian ‘other’ along the vocal axis of a ‘creole Bengali subalternity’. It predicates its contextual premise upon the transcultural encounters of Bengal’s mofussil enclaves by the Hooghly River. These enclaves developed rapidly into Portuguese, Dutch, French and Danish settlements between the sixteenth and nineteenth centuries, before being overtaken by the metropolitan colonial modernity of British Calcutta. My analysis of the creole Bengali space-times constituting such entangled histories and their interstitial legacies, revolves around the Eurasian life-world of Antony Firingi (c. 1786–1836), a Portuguese-Bengali kobi singer, viz. kobiyal, from the French comptoir, Chandernagore. Mobilizing the sonic scope of the rasa modality in Indic aesthetics, I close-read a key passage from Firingi’s kobigaan, or ‘musical verse’, duel with his rival, Bhola Moira, to decode the subaltern agency of the ‘creole Bengali rasa’ inflecting the vocal poetics of his liminal identity-narrative as a Eurasian kobiyal.
Spiritual Discourse in the Jesuit Missions: The Role of Nature in the Evangelization of Peru (Sixteenth–Seventeenth Centuries)
Authors: S.J. Juan Dejo 
Published: April 2023

Abstract
The article explores how, notwithstanding their suspicions that the devil could take advantage of the animistic beliefs of Peru’s native inhabitants to consolidate idolatry, the Jesuit missionaries ultimately became more understanding of the spiritual Andean worldview. From St. Ignatius of Loyola’s postulate of “Contemplation to Obtain Love” in the Spiritual Exercises, by which God is acting and present in nature and inhabits creatures, and thanks to their continuous contact with the aboriginal population, the Jesuit missionaries were able to better understand the indigenous relationship with nature, for example through natural medicine and pharmacopoeia. They were therefore able to bridge some gaps in an intercultural exchange that produced forms of religious hybridization that are still a feature of Andean Christianity today.
Murphy’s Law at Work: Climate Anomalies, Famine, and Mortality Crises on the Jesuit Missions among the Guaraní, 1733–40
Authors: Jackson Robert H. 
Published: April 2023

Abstract
The modern adage known as Murphy’s Law states that what can go wrong will go wrong, and could be applied to a series of unfortunate events that befell the Jesuit administered missions among the Guaraní in the years 1733 to 1740. Weather anomalies resulted in poor crops and food shortages, and at the same time, royal officials mobilized thousands of Guaraní mission militiamen. Many Guaraní fled the missions in search of food, but the military mobilization and the flight of many from the missions also spread contagion. During the crisis period more than ninety thousand Guaraní died. The Jesuits prepared narrative reports known as cartas anuas that provide details regarding the crises and particularly the food shortages not found in other sources, as well as a sense of how the Jesuits responded to the crises. Details in the cartas anuas also reveal details of the inner workings of the missions.
The Jesuit Community of the Lithuanian Province: Between Local Crises and Global Changes
Authors: Mariani Andrea 
Published: April 2023

Abstract
The paper analyzes the community of the Lithuanian province of the Society of Jesus between 1608 and 1773. It adopts a prosopographical approach based on the full set of the order’s personnel catalogs for the Lithuanian and Masovian provinces, which have been analyzed by means of RStudio, an integrated development environment based on the R programming language. The author focuses on the total number of Jesuits in the province, their religious or secular status, final vows, education, regional distribution, and geographic origin. In the long term, changes mainly depended on local factors such as the cultural assimilation of the inhabitants of the eastern territories marked by the influence of the Orthodox Church. In the short term, wars and epidemics also played an important role. However, some of the trends in the Lithuanian province, such as the number of professed of the four vows, which increased due to the larger availability of theological courses during religious formation, were similar to those in other administrative units of the Society. Overall, the article demonstrates that the seventeenth-century crises had a profound impact on the Jesuit community both in terms of numbers and internal structure.
The Siyar al-mulūk of ʿUmar b. Dāwūd al-Fārisī: A Quasi-Plagiaristic Translation of Kalīla and Dimna
Authors: Beers Theodore S. , Khalfallah Khouloud 
Published: April 2023

Abstract
In this article, we carry out an introductory study of a little-known text titled Siyar al-mulūk, written in the late seventh/thirteenth century by an author named ʿUmar b. Dāwūd al-Fārisī, and dedicated to an Ayyubid amīr of Hama. There is only one known extant copy of this work, which belongs to the collection of the Topkapı Palace Library and dates to 727/1327. ʿUmar b. Dāwūd presents what he has written, confusingly, as an “arabicization” (taʿrīb) of the classic book of fables, Kalīla and Dimna — one of the most famous versions of which was already in Arabic. In fact, the Siyar al-mulūk is a translation; but it is derived from the sixth/twelfth century Persian rendition of Kalīla and Dimna by Naṣr Allāh Munshī. Analyzing how this text relates to its sources is made somewhat more difficult by ʿUmar b. Dāwūd’s decision not to name any of them. Once the connection to the work of Naṣr Allāh is recognized, however, the Siyar al-mulūk emerges as a case study in both the evolution of Kalīla and Dimna as a global textual tradition and the transmission of Persian literature and scholarship to the Arab lands in the Mongol-Ayyubid-Mamluk period.
From Calculations to Reasoning: History, Trends and the Potential of Computational Ethnography and Computational Social Anthropology
Authors: Peponakis Manolis , Kapidakis Sarantos , Doerr Martin , Tountasaki Eirini 
Published: April 2023

The domains of computational social anthropology and computational ethnography refer to the computational processing or computational modelling of data for anthropological or ethnographic research. In this context, the article surveys the use of computational methods regarding the production and the representation of knowledge. The ultimate goal of the study is to highlight the significance of modelling ethnographic data and anthropological knowledge by harnessing the potential of the semantic web. The first objective was to review the use of computational methods in anthropological research focusing on the last 25 years, while the second objective was to explore the potential of the semantic web focusing on existing technologies for ontological representation. For these purposes, the study explores the use of computers in anthropology regarding data processing and data modelling for more effective data processing. The survey reveals that there is an ongoing transition from the instrumentalisation of computers as tools for calculations, to the implementation of information science methodologies for analysis, deduction, knowledge representation, and reasoning, as part of the research process in social anthropology. Finally, it is highlighted that the ecosystem of the semantic web does not subserve quantification and metrics but introduces a new conceptualisation for addressing and meeting research questions in anthropology.
The experience of caregiver burden when being next of kin to a person with severe chronic obstructive pulmonary disease: A qualitative study
Authors: Johansson Helena , Berterö Carina , Jonasson Lise-Lotte , Berg Katarina 
Published: April 2023

Background Chronic obstructive pulmonary disease (COPD) is an inflammatory and irreversible lung disease. For next of kin caregiver burden can be a consequence of the situation of being close to a person affected by a chronic disease and in need of help. When there is an imbalance between stressors and resources to cope with the situation, caregiver burden emerges. Knowledge is sparse about how the caregiver burden is experienced by the next of kin. Therefore, the aim of this study is to identify and describe the caregiver burden experienced by next of kin of persons with severe COPD. Method Qualitative interviews with 21 next of kin were conducted. Thematic analysis was used in accordance with the six steps of Braun and Clarke. Results The next of kin experience caregiver burden as 1) changed roles in daily life 2) putting life on hold 3) to stand aside. The next of kin are in need of support to manage daily life. Conclusions The caregiver burden affect the next of kin physically and emotionally. To prevent advance consequences, person-centered care can be used to support the next of kin in the situation.
Higher Intakes of Nutrients are Associated with Improved Health-Related Quality of Life among Individuals with Comorbidities
Authors: Nguyen Hai Duc 
Published: April 2023

There is a dearth of evidence on the association between nutrient intakes and health-related quality of life (HRQOL) among populations with comorbidities. Thus, this study aimed to identify the relationships between nutrient intake and HRQOL in a Korean population with comorbidities (4,136 adults aged ≥18 years). The EuroHRQOL five-dimension questionnaire (EQ-5D) and 24-hour recall methods were used to measure HRQOL and nutrient intake, respectively. Multivariable-adjusted logistic and linear regression models, marginal effects, and cutoff levels were applied to assess associations between nutrient intake and each dimension and the EQ-5D-3L index, as well as interactions of nutrient intake with comorbidities and sex for HRQOL. Interactions were identified between vitamin C, total vitamin A, potassium consumption, and sex for problems with depression and anxiety, problems with pain and discomfort, and any problem. Interactions were observed between monounsaturated fatty acids (MUFA) and sodium intake and comorbidities for problems with mobility and self-care problems among participants with comorbidities, respectively; between vitamin B1, vitamin B3, potassium, saturated fatty acids (SFA), fat, and cholesterol intake and comorbidities for problems with pain and discomfort; and between vitamin B1, MUFA, potassium, fiber, SFA, fat, and carbohydrate intake and comorbidities for any problems. Our findings found higher nutrient intake is associated with enhanced HRQOL in the Korean adult population. More work is needed to improve QOL by quitting smoking, eating more nutritional meals, and exercising regularly.
The Effect of Parenting Sense of Competence on Emotional and Behavioral Adjustment of Children With Special Education Needs: A Chain Mediating Model
Authors: Yan (颜廷睿) Tingrui , Hou (侯雨佳) Yujia 
Published: April 2023

Purpose This study examines the mechanism underlying the effect of parenting sense of competence (PSOC) on the emotional and behavioral adjustment of children with special education needs (SEN). Design/Approach/Methods Convenience sampling method was used and 299 parents of children with SEN were surveyed using questionnaires. Amos 24.0 was used to perform the chain mediation analyses. Findings The results showed that PSOC was positively associated with emotional and behavioral adjustment of children with SEN; parenting satisfaction negatively predicted the total difficulty of children with SEN and parenting efficacy positively affected prosocial behavior. Mediation analysis indicated that PSOC (parenting satisfaction and parenting efficacy) influenced prosocial behavior of children with SEN through parental involvement and the chain mediation effect of parenting stress and parental involvement. Originality/Value This study reveals the different pathways that parenting satisfaction and parenting efficacy—the core dimensions of PSOC—affect the emotional and behavioral adjustment of children with SEN during the transition from kindergarten to primary school.