bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint InSAR and discrete element numerical simulation method for landslide identification and monitoring: A case study of the Gongjue landslide, Jinshajiang River, China
Authors: Yang Chengsheng , Xiong Guohua , Xu Hao , Wei Yunjie , Zhu Sainan , Li Zufeng 
Published: January 2023

Abstract

Landslide disasters—prone to river blocking—are widely distributed in the mountainous areas of southwest China and are characterized by high-elevation long-runout movement with great destructive power. Identification and monitoring of high-elevation long-runout landslides and the prediction of unstable landslide movements are of great significance for regional disaster mitigation and prevention. In this study, we used interferometric synthetic aperture radar (InSAR) to identify and monitor potential landslides in Gongjue County, China and selected the Sela landslide as a model to analyze current and unstable landslide movements. The monitoring results show that Gongjue County, in the area of the Jinsha River, contains four typical landslides with slope deformation rates exceeding − 17 cm/yr. The maximum slope deformation rate reaches − 46 cm/yr. The decomposition results of the time-series deformation characteristics of the landslide feature points show that the landslide periodic term deformation has a certain correlation with rainfall. Based on the discrete element model MatDEM and InSAR monitoring results, the simulation of the movement of the Sela landslide under natural gravity and sliding instability shows that the Sela landslide is still in a stable stage under natural gravity conditions, whereas under conditions of instability, most of the landslide bodies will slide rapidly into the Jinsha River, and there is a greater risk of river blockage. The results of this study provide an important reference for carrying out remote monitoring and risk prediction for high-elevation long-runout landslides.
Heparin-Binding Protein Combined with Albumin for Assessing the Severity of Community-Acquired Pneumonia: A Retrospective Study
Authors: Liu Jing , Zhang Ying , Wang Shuo , Xu Xuelian , Hong Yiyu , Zhao Yibo , Xue Haotian , Zheng Yantao , Liu Bin 
Published: January 2023

Abstract
Background: Community-acquired pneumonia (CAP) has a high incidence rate and high mortality. Heparin-binding protein (HBP) is correlated with the severity of CAP. Albumin (ALB) is correlated with its prognosis. However, the role of HBP and ALB together (HBP–ALB) in assessing the severity of CAP is unclear. This study investigates the correlation between HBP–ALB and the severity of CAP.
Methods: A total of 91 patients with CAP admitted to the Emergency Department of Zhujiang Hospital, Southern Medical University, between March 1, 2021 and March 1, 2022 were enrolled. The patients were placed into two groups: mild CAP (mCAP; n = 69) and severe CAP (sCAP; n = 22). Patient characteristics and laboratory data were obtained. Receiver operating characteristic (ROC) curve and the value of area under the curve (AUC) were used to evaluate the predictive values of both HBP and ALB.
Results: The white blood cell (WBC) count, procalcitonin (PCT), HBP, creatinine (Cr), and D-dimer were higher in the sCAP group, while ALB was lower in the sCAP group (P < .05) than those of the mCAP group. The AUCs of WBC, PCT, HBP, and HBP–ALB were 0.674 (95% confidence interval (CI): 0.544–0.803, P < .05), 0.677 (95% CI: 0.538–0.816, P <.05), 0.776(95% CI: 0.671–0.881, P < .05), and 0.805(95% CI: 0.692–0.918, P < .05).
Conclusions: HBP–ALB has a higher predictive value than that of HBP, PCT, and WBC used alone for the early assessment of CAP.
Angiotensin Receptor Neprilysin Inhibition mediates Renal Protection by ARNI (Sacubatril Valsartan) in Rats with Spontaneous Hypertension
Authors: Guo Tao , Jiang Hui , Tang Futian , Ma Ruixin , Wang Zhuanping , Chen Jianshu , Zhuang Chenchen , Jiang Jinfang , Mou Yuping , Yu Jing 
Published: January 2023

Abstract
Background
This article aims to present research pertaining to the effect of angiotensin receptor-neprilysin double blocker on blocking the inflammatory mechanism mediated by NLRP3 inflammasome on hypertensive nephropathy. ARNI has not only been found to improve cardiac function but is also associated with a reduction in progressive deterioration of kidney function owing to hypertension by exerting anti-inflammation, anti-autophagy, anti-fibrosis and anti-Golgi’s apparatus. We hypothesized that administration of ARNI is more effective than valsartan alone in slowing progression of hypertensive renal disease.
Methods
Rat models with spontaneous hypertension were randomized into a no treatment group, valsartan group (60 mg/kg), ARNI group (70 mg/kg) or ARNI + A779 group (70 mg/kg + 400ng/kg) daily by gavage. Sprague-Dawley rats were subjected to the control conditions (without hypertension and treatment). The kidney tissue analyses were performed after 12 weeks. We detected the expression levels of NLRP3 and casepase-1 in kidney tissue, and NLRP3 levels in human embryonic kidney cells which were induced by ang II as hypertension cell model by Real-Time Polymerase Chain Reaction. To analyze the impact of ARNI on autophagy, we performed western blot analysis on renal tubules to measure the protein expression of NLRP3 inflammasome, and to measure the protein expression of P62 and LC3. Masson 3 staining method was used to stain renal fibrosis. Immunohistochemistry was performed to determine the expression sites of NLRP3. The Golgi apparatus in morphology of renal tubular cells was determined by transmission electron microscope.
Results
The untreated hypertensive renal disease rats exhibited tubular and glomerular damage, downregulation of pro-inflammatory, pro-autophagy, pro-fibrotic and pro-Golgi’s apparatus pathways. ARNI administration improved renal function and histology changes and attenuated most of the molecular markers of inflammation, autophagy, fibrosis and Golgi’s apparatus.
Conclusions
ARNI activation attenuates renal complications of arterial hypertension by reduction of kidney inflammation through selective actions requiring the renal tubular epithelium but not the glomerular endothelial cells and the circumferential mesangial interposition cell Angiotensin Receptor. ARNI was more effective than valsartan therapy alone in delaying the progression of hypertensive renal disease.
Prospective relationships of sedentary behaviors with incident depression and potential biological mediators
Authors: Hallgren Mats , Werneck André , Owen Neville , Araujo Raphael , Silva Danilo 
Published: January 2023

Abstract
Sedentary behavior (SB) is associated with depression, yet little is known about the relationship between different types of SB (e.g., passive versus mentally-active) with depression and potential biological mediators of these associations. We used cohort data from the 1958 National Child Development Study (n = 4,607;50.4% women), employing the 44y wave as baseline, and the 46y, 50y and 55y waves as follow-up. TV-viewing and watching videos (i.e., passive SB), and time sitting while doing light activities such as deskwork or driving a car during worktime (i.e., mentally-active SB) were self-reported by participants. Depression diagnosis was self-reported during the initial and follow-up waves and the participants answered the CIS-R at 44y. Waist circumference, C-reactive protein, and glycated hemoglobin were assessed at baseline and examined as potential mediators. We created Cox proportional hazards regression models, adjusting for gender, education, employment status, physical activity, tobacco smoking, and alcohol consumption at baseline. There were 636 cases of incident depression over 47,184 person-years. Passive SB was associated with higher hazards of incident depression (HR: 1.43; 95%CI: 1.19–1.71), while there was no association with mentally-active SB. Waist circumference (coefficient: -0.03; 95%CI: -0.05; -0.01; 9.2%) and C-reactive protein (coefficient: -0.03; 95%CI: -0.04; -0.01; 8.3%), but not glycated hemoglobin, partly mediated the association with passive SB. Higher durations of time spent in mentally-passive SB can increase risk of incident depression. The mediating contributions of waist circumference and C-reactive protein point to possible inflammatory-related mechanisms and suggest potential benefits of jointly addressing metabolic and mental health.
Supply chain loss from easing COVID-19 restrictions: an evolutionary epidemiological-economic modeling study
Authors: Zhang Qingpeng , Ye Yang , Cao Zhidong , Zeng Daniel Dajun 
Published: January 2023

Abstract
Since the start of the COVID-19 pandemic, many firms have been shifting their supply chains away from countries with stringent control measures to mitigate supply chain disruption. Nowadays, the global economy is reopening from the COVID-19 pandemic at various paces in different countries. Understanding how the global supply network evolves during and after the pandemic is necessary for determining the timing of reopening. By harnessing the real-world and real-time global human movement and the latest macroeconomic data, we propose an evolutionary epidemiological-economic model to explore the evolutionary dynamics of the global supply network under various global reopening scenarios. We find that the delay in full reopening in highly restrictive countries has limited public health benefits in the long run but leads to significant supply chain loss to less restrictive ones. Longer duration of stringent control measures leads to lower supply chain recovery in five years. The recovery rate varies across production sectors, depending on the characteristics of production, the degree of self-reliance, and the location of production hubs. This research presents the first data-driven evidence of supply chain loss due to the timing of reopening and sheds light on the post-pandemic supply chain reformation and recovery. Our results provide data-driven evidence that supports the reopening in countries with high vaccine coverage.
Intention to Use Eight Antenatal Care Model and Associated Factors Among Pregnant Women Who Come for Antenatal Care in Northwest of Amhara Region Referral Hospitals, Ethiopia, 2021
Authors: Semaw Eyuel Amare , Kebede Azmeraw Ambachew , Admassu Endeshaw , Yehuale Samuel Kefelegn , Ketema Anteneh Gashaw 
Published: January 2023

Abstract

Background:Maternal and perinatal mortality is highly associated with four or fewer antenatal care (ANC) visit. Due to this, WHO develop a new model called minimum of eight antenatal care (ANC8+) contact. This model is used to re- think and re- design the service through context specific expectations. Besides, the model is beyond survival, aim to maximize health and wellbeing of women even at post pregnancy motherhood, and social health of the family and community at large. Since shortage of related studies in Ethiopia so far, this study aim to address those gaps.
Objective:To assess intention to use ANC8+ model and associated factors among pregnant women who come for antenatal care contact in Northwest of Amhara region referral hospitals, Ethiopia, 2021.
Method:An institution-based cross-sectional study was conducted from September 1st to October 30th, 2021 in Northwest of Amhara regional state referral hospitals. A multistage sampling technique was used to select 847 eligible women. A structured, pretested, and interviewer-administered questionnaire was employed. EPI data version 4.6 and SPSS version 23 were used for data entry and analysis, respectively. Binary logistic regression model was fitted to identify factors associated with pregnant women intention to use ANC8+ model. A p-value of ≤ 0.05 was used to declare statistical association in the last model.
Result:Overall, 739 (88.8%, 95% CI: 86.68, 90.97) women had the intention to use ANC8+. Pregnant women in the age group between 20 to 30 years (AOR = 19.84, 95% CI: 3.01, 130.64), and ≥ 31 years (AOR = 3.92, 95% CI: 1.79, 8.58), being farmer in occupation (AOR = 0.13, 95% CI: 0.04, 0.43), government employee (AOR = 5.58, 95% CI: 1.64, 18.97), good attitude (AOR = 38.76, CI 5.99, 250.73), positive subjective norm (AOR = 10.83, 95% CI: 4.36, 26.92) and perceived behavioral control (AOR = 8.98, 95% CI: 3.26, 24.71) were factors associated with women’s intention to use ANC8+.
Conclusion:More than four-fifths of the pregnant women had intention to use ANC8+. Increase in age, being the government employee , having good attitude, positive subjective norm and perceived behavioral control were positively, while being a farmer negatively associated to intention to use ANC8+ contact. Therefore, empowering women, developing socio cultural integrity with the health system through health education and trainings to local health cadres and community leaders would possibly increase the intention of using ANC8+.
Anthropogenic impact on the severity of compound extreme high temperature and drought/rainy events in China
Authors: Sun Bo , Li Wanling , Wang Huijun , Zhou Botao , Li Huixin , Xue Rufan , Duan Mingkeng , Luo Xiaochun , Ai Wenwen 
Published: January 2023

AbstractExtreme events seriously affect human health and natural environment. In the present study, several indexes that can describe the severity of compound extreme high temperature and drought/rainy events (CHTDE/CHTRE) are constructed based on copulas. According to observations, CHTDE and CHTRE have intensified in most areas of China during 1961–2014. The significant increase trend in the severity of CHTDE and CHTRE is basically consistent with simulations under historical anthropogenic forcing. This result proves that changes in CHTDE can be largely attributed to anthropogenic climate change. The historical greenhouse gas forcing is identified to be the dominant factor that affects the severity of CHTDE in China, particularly in the Tibetan Plateau and Northwest China. Moreover, the contribution of anthropogenic forcing to the linear change of the CHTRE severity in China is more than 90%. In addition, the ozone and land use signals also can be detected on change of CHTDE and CHTRE.
Lipidomic and transcriptomic profiles of lipid biosynthesis and accumulation during seed development in sesame
Authors: Zhang Yujuan , Gong Huihui , Cui Xinxiao , Gao Chunhua , Li Nana , Pu Yanyan , Zhang Xiurong , Zhao Junsheng 
Published: January 2023

Abstract
Background
Sesame is one of the most important oilseed crops and attracts significant attention because of its huge nutritional capacity. However, the molecular mechanisms underlying oil accumulation in sesame remains poorly understood.
Results
In this study, lipidomic and transcriptomic analyses in different stages of sesame seed (Luzhi No.1, seed oil content is 55.67%) development were performed to gain insight into the regulatory mechanisms that govern differences in lipid composition, content, biosynthesis, and transport. In total, 481 lipids, including fatty acid (FA, 38 species), triacylglycerol (TAG, 127 species), ceramide (33 species), phosphatidic acid (20 species), and diacylglycerol (17 species), were detected in developing sesame seeds using gas and liquid chromatography-mass spectrometry. Most FAs and other lipids accumulated 21–33 days after flowering. RNA-sequence profiling in developing seeds highlights the enhanced expression of genes involved in the biosynthesis and transport of FAs, TAGs, and membrane lipids, which is similar to that in the process of lipid accumulation. Through the differential expression analysis of genes involved in lipid biosynthesis and metabolism during seed development, several candidate genes were found to affect the oil content and FA composition of sesame seeds, such as ACCase, FAD2, DGAT, G3PDH, PEPCase, WRI1 and WRI1-like genes.
Conclusions
Our study firstly provides the patterns of lipid accumulation and biosynthesis-related gene expression and lays an important foundation for the further exploration of sesame seed lipid biosynthesis and accumulation.
Development and Assessment of a Leadership Program for Dentistry Students
Authors: Davari Azadeh , Taheri Pardis , Sadeghi Hanieh , Etebarian Arghavan 
Published: January 2023

Abstract
Introduction:
The emergence of disparate opportunities and challenges in the twenty-first century emphasizes the importance of leadership training in dentistry. Therefore, a reflective, interactive, and collaborative training workshop in this field can positively improve the pioneer dentists' knowledge, mindset, and skillset.
Aims
This article aimed to share the foundation of the leadership program, design expected outcomes, evaluate the program's effectiveness in a dental school in Iran, and discuss the importance of leadership skills for dentistry students.
Design:
We conducted a program design and research evaluation based on a mixed-method approach. A two-day leadership development program was developed and held in Alborz dental school in Karaj, Iran. A group of 20 dentistry students participated in the program. Then, the program was evaluated twice, once just after the program and once six months later,
Results
90% of the participants rated the course 4 or higher (4.5 on average) on a 5-point satisfaction scale, in which 1 meant utterly dissatisfied and 5 meant completely satisfied. The highest average score was for the Leadership from Inside-out module (4.55 of 5). In addition, the students rated teamwork practice as the most challenging part and presentation skills as the most influential module of the program. Furthermore, according to this survey, 80% of the students will participate in future leadership programs with high satisfaction, and 95% of the students recommended it as an extra-curricular activity for all students in dental school.
Conclusion
The program's facilitators provided an exceptional opportunity and psychologically-safe environment for students to learn leadership skills. Training leadership as non-clinical skills can be beneficial for dentistry students, and it can positively affect the dental profession and ultimately effective healthcare systems. Therefore, including voluntary leadership courses in undergraduate and postgraduate dental curricula is recommended.
Potential Utility of Risk Stratification for Multicancer Screening with Liquid Biopsy Tests
Authors: Chatterjee Nilanjan , Kim Elle , Scharpf Robert , García-Closas Montserrat , Visvanathan Kala , Velculescu Victor 
Published: January 2023

Abstract

Our proof-of-concept study reveals the potential of risk stratification by the combined effects of age, polygenic risk scores (PRS), and non-genetic risk factors in increasing the risk-benefit balance of rapidly emerging non-invasive multicancer liquid biopsy tests for early cancer detection. We develop and validate sex-specific pan-cancer risk scores (PCRSs), defined by the combination of body mass index, smoking, family history of cancers, and cancer-specific polygenic risk scores (PRSs), to predict the absolute risk of developing at least one of the many common cancer types. We demonstrate the added value of PRSs in improving the predictive performance of the risk-factors-only model and project the positive predictive values for two promising multicancer screening tests across risk strata defined by age and PCRS.
Efficacy of Cingulotomy for Refractory Malignant Cancer Pain: A Case Series
Authors: Fitzgerald Hillary , Sandhu Harkiran , Tombazzi Claudio , Paulo Danika , Tillman Stacey , Misra Sumathi , Shah Hamid , Karlekar Mohana 
Published: January 2023

Abstract
Purpose
Poorly controlled pain is a significant quality of life issue for patients with advanced cancer. Patients often suffer from uncontrolled pain or intolerable side effects of treatment despite receiving multi-modal care with stepwise escalation of opioids. Interventional procedures impacting central pain pathways have demonstrated promise in treating pharmacologically intractable cancer pain and may be underutilized, especially in patients with escalating opioid use. The aim of this study was to assess effectiveness of bilateral anterior cingulotomy—a minimally invasive neurosurgical procedure—in patients with refractory malignant cancer pain through describing opioid use trends pre- and post-procedure and by comparing pain scores.
Methods
This is a retrospective review of a case series of six patients with refractory malignant pain who underwent bilateral anterior cingulotomy. Response to procedure was measured by percent change of pain scores and average daily opioid dose reduction. In addition, demographics, oncologic history, discharge disposition, survival time post-procedure, and complications were reported.
Results
Six unique patients underwent seven total procedures between 2019–2022. Average daily OME (oral morphine equivalent) dose 48 hours prior to procedure was 4411 mg. At discharge, average daily OME dose was 250 mg, an 89% dose reduction from 48 hours prior to procedure. Pain scores reduced by 43% during this same time period.
Conclusion
Cingulotomy effectively reduced pain scores with a concurrent reduction in opioid dosing in our cohort of patients with medically refractory malignant cancer pain. Further research is warranted to identify advanced cancer patients who may benefit most from this procedure and inform clinical adoption.
Species redistribution creates unequal outcomes for multispecies fisheries under projected climate change
Authors: Liu Owen , Ward Eric , Anderson Sean , Andrews Kelly , Barnett Lewis , Brodie Stephanie , Carroll Gemma , Fiechter Jerome , Haltuch Melissa , Harvey Chris , Hazen Elliott , Hernvann Pierre-Yves , Jacox Michael , Kaplan Isaac , Matson Sean , Norman Karma , Buil Mercedes Pozo , Selden Becca , Shelton Andrew , Samhouri Jameal 
Published: January 2023

Abstract
Climate change drives species distribution shifts, impacting the availability of resources people rely upon for food and livelihoods. These impacts are complex, manifest at local scales and have diverse effects across multiple species. Yet, for wild capture fisheries current understanding is dominated by predictions for individual species at coarse spatial scales. We show that localized environmental changes that vary across species will alter the ensemble of co-occurring fishery species within established fishing footprints along the U.S. West Coast. We demonstrate that availability of the most economically-valuable, primary target species is highly likely to decline coastwide in response to warming and reduced oxygen concentrations, while availability of the most abundant, secondary target species will potentially increase. A spatial reshuffling of primary and secondary target species suggests regionally heterogeneous opportunities for fishers to adapt by changing where or what they fish. Developing foresight into the collective responses of species at local scales will enable more effective and tangible adaptation pathways for fishing communities.
Child sexual abuse awareness among parents visiting Pediatric outpatient hospital services
Authors: Parvin Tabbasum , Nagarajan Padmavathi , Kattimani Shivanand , Chandrasekaran Venkatesh , Seth Rajeev 
Published: January 2023

Abstract
Objectives
To measure the awareness level of parents using child sexual abuse awareness scale
Methods
We conducted the survey among parents visiting a Pediatric outpatient services of a large tertiary care hospital
Results
Mean age of the participants was 31.8 years (range 19–52 years). Out of the 273 participants, we had equal representation from both genders. 63% were from rural residential background. Scores on CSA awareness significantly associated with participants' level of education [Kruskal-Wallis test, Chi-square (df) = 9.139 (3), p value = 0.027], and location of residence [Mann Whitney U test, Z value =-3.081, P value = 0.002]. We found a significant correlation between the level of CSA awareness and age, monthly household income of the participants (rho = 0.124, p value = 0.041; rho = 0.214, p value = 0.000).
Conclusions
Our participants had overall better awareness on CSA as parents. Level of CSA awareness among parents was significantly better in those with higher education, and those hailing from urban residential location.