bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of long-acting insulin degludec in adult patients with type 2 diabetes mellitus in real clinical practice in Russia
Authors: Galstyan G. R. 
Published: February 2023

BACKGROUND: Effective glycaemic control remains the most important task in managing the risks of Diabetes type 2 complications development. In this regard, the choice of insulin preparations with minimal variability of action is of utmost importance since this approach allows achieving the maximum treatment effectiveness and adequate safety level.AIM: The aim of this study was to investigate insulin degludec treatment effect on glycemic control in adult patients with Diabetes Mellitus (DM) type 2 in a real-world clinical setting in the Russian Federation.MATERIALS AND METHODS: The open prospective study was conducted in 2020–2021 in 35 clinical centers in 31 cities of the Russian Federation. The study included adult patients with type 2 DM treated according to Russian routine clinical practice. The prospective follow-up period was 26 weeks. The main study endpoints were changes in HbA1c level, fasting plasma glucose, insulin daily doses, number, and characteristics of different types of hypoglycaemia episodes and adverse events (AEs), and patient preferences compared to previous treatment.RESULTS: The study enrolled 494 patients. By the end of follow-up period:The mean HbA1c decrease was 1.6% (p<0.0001).Fasting plasma glucose level decreased by 3.4 mmol/L (p<0.0001).Daily basal and prandial insulin doses decreased by 1.6 IU/day (p<0.0001) and 2.1 IU/day (p<0.01), respectively.Severe episodes of hypoglycemia did not occur, while the incidence of nonsevere episodes decreased significantly.76 patients (15.4%) had 105 AEs, of which 41 (in 33 patients, 6.7%) were serious.COVID-19 was the most frequent AE reported in 21 patients (4.3%).Only in one case insulin degludec was withdrawn due to the patient’s pregnancy and the AEs that arose from it.Most patients (98.6%) preferred insulin degludec to previous treatment.CONCLUSION: The study demonstrated a statistically significant improvement in glycemic control, accompanied by basal insulin dose decrease combined with the absence of severe episodes of hypoglycemia, and significant decrease of nonsevere episodes (total and nocturnal). These results led to a large proportion of patients wanting to continue insulin degludec treatment preferring the medicine over previous treatment.
Clinical and epidemiological characteristics of male hypogonadism in type 2 diabetes in Russia: combined analysis of study data for the period 2005–2022
Authors: Chernova M. O. , Esaulenko D. I. , Rozhivanova E. R. , Rozhivanov R. V. , Mel’nichenko G. A. , Shestakova M. V. , Mokrysheva N. G. 
Published: February 2023

Background:Male hypogonadism is associated with type 2 diabetes mellitus (T2DM), therefore, it is of interest to study its clinical and epidemiological characteristics. These data are published, but their fragmentation and small sample sizes are a problem. A summary assessment of the combined primary data of the conducted studies will provide sufficient representativeness and will allow to extrapolate the results to the general Russian population with T2DM.Aim:Assessment of the clinical and epidemiological characteristics and aggravating factors of male hypogonadism in T2DM in Russia.Materials and methods:A Combining primary data (anamnesis, anthropometric indicators, laboratory tests) of full-design, cross-sectional, screening studies of hypogonadism in men with T2DM conducted on the territory of the Russian Federation in the period from 2005 to 2022. The groups were compared using the Mann-Whitney U-test for quantitative indicators and χ² with Yates’ correction for qualitative ones. Differences were considered statistically significant with p <0,05. The groups were compared using the Mann-Whitney U-test and χ² with Yates correction. Differences were considered statistically significant at p<0.05.Results:Hypogonadism was detected in 893 of 1576 men (56,7%) with T2DM. Patients with hypogonadism were statistically significantly older, had higher body mass index (BMI), worse glycemic control than eugonadal men. There was ­statistically significantly higher prevalence of macroangiopathies and polyneuropathy in hypogonadal patients.Conclusion:The prevalence of male hypogonadism in T2DM 56,7%. Its development is due to age, obesity, worse glycemic control. Hypogonadism syndrome is associated with the development of diabetic macroangiopathy and polyneuropathy. Severe violation of glycemic control (glycated hemoglobin (HbA1c) 10% or more) significantly reduces testosterone production and increases the prevalence of hypogonadism.
Clinical evaluation of the implementation of the first pilot Russian integrated program for an integrated approach to the management of diabetes mellitus “NORMA”
Authors: Galstyan G. R. , Mayorov A. Y. , Melnikova O. G. , Holmskaya N. I. , Hamradjanov Z. A. , Milyutin V. I. , Shestakova M. V. 
Published: February 2023

BACKGROUND: Despite progress in the treatment of patients with diabetes mellitus (DM), the problem of achieving target values of glycemic control remains relevant. In this regard, the search for new integrated solutions that could strengthen disease control and improve clinical outcomes becomes relevant.AIM: To assess the impact of the developed integrated approach to disease management on the clinical and metabolic outcomes of patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) participating in the “NORMA” pilot program for 3 and 6 months.MATERIALS AND METHODS: “NORMA” is the first Russian program designed to implement an integrated approach to DM management combines structured online education, blood glucose monitoring, supervision by endocrinologist, and administrative support. Interium retrospective analysis analysis of pre-existing data generated in the Program was performed from October 2020 to November 2021. Adults (≥18 years) with uncontrolled T1DM or T2DM on insulin (HbA1c>7,0%) with duration of DM ≥6 months were included. The following characteristics were considered: social-demographic parameters, duration of DM, complications, HbA1c, hypoglycemia events, daily insulin dose, patients’ perception of DM checklist (scaled 1-10), level of DM knowledge (questionnaire of 20 points).RESULTS: Data from 185 persons were analyzed: 132 with T1DM and 53 with T2DM, 67% women, the mean age was 41.3±14.4 years; the median DM duration was 12.0 [6.0; 19.0] years, 30 persons (16.3%) were free of any DM complications. Mean HbA1c decreased from 8.8±1.5% to 7.4±1.2% at month 3, and to 7.6±1.5% at month 6 (p<0.001). HbA1c <7.0% was achieved in 38.9% and 38.1% participants after 3 and 6 months, respectively. The total insulin dose has not changed within the program. The DM knowledge level after 3 months of Program increased significantly by 25.4±15.0% (p<0.001). The mean scores of patients’ perceptions of DM after 3 and 6 months increased by 2.1±10.2 % and 2.4±11.0 % (p<0.01), but the median scores (interquartile range) did not change: 0.00% (-3.00–6.00%) and 0.50% (-3.00–9.00%) respectively.CONCLUSION: In a real-life setting, the implementation of an integrated approach to the diabetes management was associated with the improvement of glycemic control without significant changes of total insulin dose.
The technical and economic analysis of processing and conversion of heavy oil cuts to valuable refinery products
Authors: Pirouzfar Vahid , Mohamadkhani Fariba , Van Nguyen Nguyen , Su Chia-Hung 
Published: February 2023

Abstract
Many of the modern refineries are founded on converting/upgrading the heavy bases of low value to lighter products by higher added value like gasoline, jet fuel and diesel fuel. In this work, some process configurations in heavy refinery cracking, converting and treating are technically and economically evaluated. In this purpose, four process configurations for refinery plants are suggested. These processes are evaluated and analyzed to obtain the most optimal configurations with the aim of achieving the most valuable refinery products. The difference of the processes is in heavy residue conversion and processing. These processes are included the Asphalt Air Blowing Unit (AABU, Type 1), Delayed Coker Unit (DCU, Type 2), Heavy Residue Hydro-Conversion (HRH, Type 3) and Solvent De-Asphalting (SDA, Type 4). The units are common in mentioned refineries cases and just ABU, HCU, DCU, HRH and SDA are different. In economic consideration, the payout period is considered as one of the standard methods of assessing the economic projects and economically estimating them. As results, the highest rate of gasoline is recorded in the refinery type of DCU unit and the highest amount of LPG/C4/C3, kerosene and gasoline production observed in refinery type of HRH unit. The construction of refinery with ABU unit has minimum investment (980 million $) and highest rate of return (19.4).
Early-Age Cracking Potential of Fly Ash High Performance Concrete Internally Cured with Super Absorbent Polymers
Authors: Wen Chuyuan , Shen Dejian , Luo Yueyao , Wang Wenting , Yao Panpan 
Published: February 2023

Abstract
Early-age cracking is problematic for high performance concrete (HPC) made with a low water/binder ratio. The application of fly ash (FA) as a cement replacement can contribute to reduced CO2 emission and clinker factor, as well as improved durability of HPC. Super absorbent polymers (SAPs) were also applied for better curing and a higher rate of hydration to optimize the FA HPC. The current study utilized a temperature stress test machine to investigate the early-age cracking potential of FA HPC with internal curing by SAPs. Test results and the related analyses suggested that the introduction of internal curing alleviated the autogenous shrinkage, restrained stress, as well as tensile creep for HPC with 0 % and 20 % FA replacement level. The application of SAPs reduced the cracking potential of HPC with a low FA replacement level, whereas it aggravated the cracking when the FA replacement level was high.
Learning Models To Increase Learning Motivation Through The Application Of Bandlab
Authors: Budiawan Hery Budiawan , Nurmalasari Siti Pujawati 
Published: February 2023

The purpose of this study is to determine whether there is a difference in the level of student learning motivation between classes and the use of application-based learning media, namely bandlabs with classes without the use of bandlab learning media at SMPN 24 Jakarta. And the second is the supporting factor and inhibition of class VII learning motivation at SMPN 24 Jakarta.
The method used quantitative research method with Post Test Only Control Group Design. Data that has been distributed is processed and processed using the Likert scale. The data analysis techniques used in this study are t test analysis and homogeneity test.
The results of this study show that there is no significant difference in student learning motivation between classes and the use of application-based learning media, namely bandlabs with classes without the use of bandlab learning media. This is supported by research data on significance values of 0.856 > 0.05. The research was conducted online from their respective homes through online media Whatsapp and Zoom Meeting
Is seminal nerve growth factor-induced luteinizing hormone release in camelids mediated at the hypothalamus?
Authors: Carrasco Rodrigo A , Pezo Sergio , Zwiefelhofer Eric M , Lanigan Emily E , Singh Jaswant , Berland Marco A , Ulloa-Leal Cesar , Ratto Marcelo H , Adams Gregg P 
Published: February 2023

In brief
Seminal nerve growth factor induces ovulation in camelids by influencing the secretion of gonadotrophin-releasing hormone (GnRH) into the portal vessels of the pituitary gland. We show that the nerve growth factor-induced release of GnRH is not mediated directly through interaction with hypothalamic neurons.

Abstract
Ovulation in camelids is triggered by seminal nerve growth factor (NGF). The mechanism of action of NGF appears to occur via the central nervous system. In this study, we tested the hypothesis that NGF acts in the hypothalamus to induce GnRH release. To determine if NGF-induced ovulation is associated with a rise in NGF concentrations in the cerebrospinal fluid (CSF), llamas were i) mated with an urethrostomized male, ii) mated with intact male, or given intrauterine iii) seminal plasma or i.v.) saline (Experiment 1). To characterize the luteinizing hormone (LH) response after central vs peripheral administration, llamas were treated with saline (negative control) or NGF either by i.v. or intracerebroventricular (ICV) administration (Experiment 2). To determine the role of kisspeptin, the effect of ICV infusion of a kisspeptin receptor antagonist on NGF-induced LH secretion and ovulation was tested in llamas (Experiment 3). In Experiment 1, a surge in circulating concentrations of LH was detected only in llamas mated with an intact male and those given intrauterine seminal plasma, but no changes in CSF concentrations of NGF were detected. In Experiment 2, peripheral administration (i.v.) of NGF induced an LH surge and ovulation, whereas no response was detected after central (ICV) administration. In Experiment 3, the kisspeptin receptor antagonist had no effect on the LH response to NGF. In conclusion, results did not support the hypothesis that NGF-induced ovulation is mediated via a trans-synaptic pathway within the hypothalamus, but rather through a releasing effect on tanycytes at the median eminence.
Identification of circular RNAs as regulators and noninvasive biomarkers for placenta accreta spectrum
Authors: Shi Junfang , Yang Mengtian , Cao Xin , Huang Qitao , He Fang , Peng You , Cui Jinru , Chen Wenqian , Xu Yiming , Geng Wenyan , Xia Laixin , Chen Dunjin , Xiao Shan 
Published: February 2023

In brief
Placenta accreta spectrum (PAS) has an urgent need for reliable prenatal biomarkers. This study profiled the circular RNAs (circRNAs) in PAS placenta and maternal blood and identified two circRNAs can regulate trophoblast cells invasion and serve as noninvasive prenatal biomarkers for PAS prediction.

Abstract
PAS is one of the most alarming obstetric diseases with high mortality rates. The regulating mechanism underlying PAS remains to be investigated, and reliable blood biomarkers for PAS have not emerged. Circular RNAs (circRNAs) have become important regulators and biomarkers for disparate human diseases. However, the circRNA profiles of PAS were not reported, and the regulatory role and predictive value of circRNAs in PAS were unknown. Here, we comprehensively profiled the circRNAs in the placenta of PAS by transcriptome sequencing and analysis and uncovered 217 abnormally expressed circRNAs. Through competing endogenous RNA network analysis, we found that the target genes of upregulated circRNAs in PAS were enriched in placenta development-related pathways and further uncovered two circRNAs, circPHACTR4 and circZMYM4, that could regulate trophoblast cells invasion and migration in vitro. Finally, we verified that circPHACTR4 and circZMYM4 were also upregulated in the maternal peripheral blood of PAS women before delivery using transcriptome sequencing and RT-qPCR and evaluated their predictive value by ROC curves. We found that circPHACTR4 and circZMYM4 could serve as effective predicting biomarkers for PAS (area under the curve (AUC): 0.86 and 0.85) and propose an improved model for PAS prenatal prediction by combining the conventional ultrasound diagnosis with the new circRNA predictive factors (AUC: 0.91, specificity: 0.89, sensitivity: 0.82).Altogether, this work provides new resources for deciphering the biological roles of circRNAs in PAS, identified two circRNAs that could regulate trophoblast cells invasion during placentation, and revealed two noninvasive diagnostic markers for PAS.
Analisi e rappresentazione cartografica delle spartizioni polacche nella manualistica scolastica e storiografia comunista e postcomunista
Authors: Banach Mirela Marta 
Published: February 2023

Analysis and cartographic representation of the Polish Partitions in school manuals and the communist and post-communist historiographyThe overall purpose of this comparative study is to analyze the substantial differences that emerge in the treatment of the Polish Partitions by the Marxist school manual in its various editions of the same content, with respect to the 1991 text of “transition” – in perpetuated oscillation between the will to fill the void of the historical inattention overcome in the aftermath of the collapse of the Berlin Wall and the inability to fill it up – and that of the “Nowa Era” history manual – one of the most widely adopted by secondary schools in Poland – that encapsulates the contributions of new historiography by turning on the spotlight on unprecedented interpretative evaluations. The non-unitarity of the historiographic analysis of the matter in question is further confirmed by the analysis of the map sources of the respective manuals, revealing the partial nature of the cartographic document whose deliberate deformations lead to merely ideological denotations.
Szpitale diecezji kamienieckiej około 1830 roku
Authors: Szczepaniak Jan 
Published: February 2023

In the Old Polish period hospitals were not institutions where the ill were treated but rather the places were responsible for providing care for those who needed help. The situation was similar about 1830. There were a lot of factors which had an essential influence on condition of hospitals and charity in the Diocese of Kamyantes about 1830; the factors were: dispersion of believers, poverty prevailing among Podolian presbyteries and cloisters, as well as strictly connected with the poverty of believers: farm nobility, few Polish townspeople, and Polish peasantry which colonized land ruined by Turks. The fall of the Republic and anti-Polish and anti-Catholic policy of czar’s authorities deepened processes of pauperizations believers of the Catholic Church. Taking all these factors into consideration, we ought to be surprised at the poor shape of parish hospitals and almost complete lack of church hospitals which above all would treat the ill (they were only in Gródek). Looking after a few dozens of the ill in 30 hospitals, with money coming from almost only from the alms, ought to be regarded as huge success of that society. The funds which parsons and superiors of cloisters had in their disposal influenced on condition of buildings, a number of people living in them, quality of their daily food and clothes which they could have at their disposal. It is also necessary to underline that on Podolia the process of disappearing of parish hospital shelters which began on the turn of the XVIIIth and XIXth centuries on lands inhabited mostly by Poles.
Anti-SARS-CoV-2 spike receptor binding domain (S-RBD) IgG antibodies following CoronaVac administration: a longitudinal study. Anti-SARS-CoV-2 S-RBD IgG antibodies
Authors: Liana Ph. , Fertilita S. , Amalia E. , Larasati V. , Rasyid R. S.P. , Zulissetiana E. F. , Sabloak R. , Sari Z. U. 
Published: February 2023

Reports on antibody titers following CoronaVac administration are still scarce, particularly when it comes to the post-vaccination effectiveness of CoronaVac in the Indonesian population. The purpose of this study is to determine the efficacy of COVID-19 vaccination by comparing the IgG levels against the S1 subunit of SARS-CoV-2 RBD after the first and second vaccinations. The researchers collected venous blood samples from participants after they received the CoronaVac 600 SU/0.5 mL vaccine at two different intervals (14 days and 28 days). Blood was drawn twice (after the first and second vaccinations) and tested for antibodies (positive antibody detection value of 50 AU/mL). Paired data were analyzed by using either the Wilcoxon test (numerical) or the McNemar test (categorical). The median IgG1 levels in the 14-day interval between vaccine doses were 64.40 AU/mL and IgG2 levels were 886.10 AU/mL. Meanwhile, the median IgG1 level was 146.10, and IgG2 level was 688.00.AU/mL in the group with a 28-day interval between vaccine doses. After the first vaccination, 60.00 % of study subjects had positive IgG levels, which increased to 98.57% after the second vaccination. Following the full-dose vaccination, all participants had higher antibody levels, and considered significant. The effect was stronger in the group that received the vaccine at 14-day intervals. CoronaVac has also been shown to increase the prevalence of detectable antibody positivity in study participants.
Dynamics of cytokine status of blood serum in adolescents with varicocele
Authors: Pichugova S. V. , Lagereva Yu. G. , Beikin Ya. B. 
Published: February 2023

Varicocele is a varicose dilation of pampiniform plexus veins in testicular gland, considered a special case of phlebopathy. With varicocele, there is impaired venous outflow via the left renal vein from the veins of testicular pampiniform plexus. Increased hydrostatic pressure leads to failure of the wall tone of the testicular vein, valvular venous insufficiency with dilation of the local venous system. Vasodilation requires integrity of endothelial layer, and its damage resulting from hydrodynamic stress is a trigger for development of an inflammatory response and production of cytokines. Pro-inflammatory cytokines have a pronounced damaging effect on endothelial cells, leading to endothelial dysfunction and chronic inflammation. Angiogenesis is an important characteristic of inflammatory disorders. Both inflammation and its controlling mechanisms employ many common factors, including IL-1β, IL-6, IL-8, TNFα. The purposes of our study were: to determine the dynamics of the pro- and anti-inflammatory cytokine levels, and VEGF contents in blood serum of adolescents with left-sided varicocele in order to assess the severity of inflammatory reaction of the vessels in the pampiniform plexus as well as prognosis of angiogenesis and remodeling of the testicular veins. We examined 100 adolescents with left-sided varicocele II-III degree and 30 adolescents without varicocele, who made up the comparison group. All adolescents (14 to 17 years old) underwent determination of IL-1β, IL-6, IL-8, TNFα, IL-4, IL-10, VEGF levels in blood serum at a frequency of 1 year, depending on the degree of varicocele, terms after varicocelectomy.Statistically higher levels of pro-inflammatory cytokines were found over different age periods in adolescents with varicocele, as well as increased levels of anti-inflammatory cytokines, which may suggest an inflammatory process in testicular veins associated with varicocele. Higher levels of pro-inflammatory cytokines were found in patients with grade III varicocele compared with patients with grade II condition, but without statistically significant differences. In adolescents prior to varicocelectomy, significantly higher levels of cytokines were determined, which persisted over the postoperative period. Based on these results, one may assume that, in phlebopathy, the inflammatory process persists until surgical correction, and adaptation to the changed blood flow after surgery does not take time. VEGF values remain approximately similar over the observation period, and, probably, the changes of the vessel walls occur due to inflammatory process, and not to activation of angiogenesisIn varicocele disorder, an inflammatory status is observed in the altered testicular venous plexus, being more pronounced in grade III varicocele and affected by subsequent surgical correction.