bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulating contact properties by molecular layers in organic thin‐film transistors
Authors: Sun Li , Li Yating , Xie Jiacheng , Zhou Liqi , Wang Peng , Xu Jian‐Bin , Shi Yi , Wang Xinran , He Daowei 
Published: September 2023

AbstractAdvanced organic devices and circuits demand both ultrahigh charge carrier mobilities and ultralow‐resistance contacts. However, due to a larger access resistance in staggered organic thin‐film transistors (OTFTs), the achievement of ultralow contact resistance () is still a challenge. The modulation of contact resistance by molecular layers near the interface has been rarely reported. Here, we demonstrate that few‐layer organic single crystals are grown on hafnium oxide (HfO2) by solution‐shearing epitaxy. We utilize these organic crystals to fabricate bottom‐gate staggered OTFTs with different contact processes. The results show that the contact properties of OTFTs are obviously modulated by crystal layers. The tri‐layer (3L) evaporated‐Au C10‐DNTT OTFTs exhibit optimal electrical performance, including ultralow of 5.6 Ω ∙ cm, recorded transfer length of 0.4 μm, field‐effect mobility over 14 , threshold voltage lower than 0.3 V, and long‐term air stability over 8 months. The main cause is that the metal atoms can penetrate into the charge transport layer, with damage‐free, in 3L evaporated‐Au OTFTs; nevertheless, it cannot be realized in other cases. Due to layer stacking of conjugated molecules and polymers, our strategy can efficiently modulate the contact resistance to aid the development of high‐performance organic devices and circuits.
Production and characterization of composite activated carbon from potato peel waste for cyanide removal from aqueous solution
Authors: Salman Sami D. , Rashid Israa M. 
Published: September 2023

AbstractThis research presents a response surface methodology (RSM) with I‐optimal method of DESIGN EXPERT (version 13 Stat‐Ease) for optimization and analysis of the adsorption process of the cyanide from aqueous solution by activated carbon (AC) and composite activated carbon (CuO/AC) produced by pyro carbonic acid microwave using potato peel waste as raw material. Pyrophosphate 60% (wt) was used for impregnation with an impregnation ratio 3:1, impregnation time of 4 h at 25°C, radiant power of 700 W, and activation time of 20 min. Batch experiments were conducted to determine the removal efficiency of cyanide from aqueous solution to evaluate the influences of various experimental parameters such as contact time, cyanide concentration, initial pH, and dosage of adsorbent on cyanide removal efficiency. The statistical analysis showed that the quadratic model was significant. The model very low probability value (p‐value < 0.0001) for activated carbon and composite activated carbon, and the analysis of variance showed a high coefficient of specification values of adjusted R2 (model accuracy with observation) and predicted R2 (model accuracy without observation). The optimum conditions suggested by the model for the process variable were 160 min, pH = 10, 10 mg/L, 0.1 g/50 mL, for time, pH, concentration, activated carbon, and composite activated carbon dose, respectively. The maximum removal efficiency at these conditions was 98.2% for AC and 99.35% for CuO/AC. The equilibrium adsorption data obtained were analyzed by Langmuir and Freundlich isotherm models and results showed that it was better described by the Freundlich model. Likewise, the data of adsorption kinetic was analyzed using two models: pseudo‐first‐order and pseudo‐second‐order. The results showed that adsorption kinetics was well performed by the pseudo‐second‐order model.
Interval time series forecasting: A systematic literature review
Authors: Wang Piao , Gurmani Shahid Hussain , Tao Zhifu , Liu Jinpei , Chen Huayou 
Published: September 2023

AbstractInterval time series forecasting can be used for forecasting special symbolic data comprising lower and upper bounds and plays an important role in handling the complexity, instability, and uncertainty of observed objects. The purpose of this research is to identify the most widely used definition of interval time series; classify existing research into mature research, current research focus, and research gaps within the defined framework; and recommend future directions for interval forecasting research. To achieve this goal, we have conducted a systematic literature review, comprising search strategy planning, screening mechanism determination, document analysis, and report generation. During the search strategy planning stage, eight literature search libraries are selected to obtain the most extensive studies (total of 525 targets). In the screening‐mechanism determination stage, through the inclusion and exclusion mechanism, the literature that is repetitive, of low‐relevance, and from other fields are discarded, and 125 studies are finally selected. In the document analysis stage, tag‐based methods and classification grids are selected to analyze the shortlisted studies. The results show that there are still numerous research gaps in interval time series forecasting, such as the establishment of hybrid models, application of multisource information, development and application of evaluation techniques, and expansion of application scenarios. In the report‐generation stage, the problems that have been solved and encountered in interval forecasting are summarized, and future research directions are proposed. Finally, the most significant contribution of this research is to provide an overview of interval time series forecasting for easy reference by researchers and to facilitate further research.
Phellinus merrillii extracts induce apoptosis of vascular smooth muscle cells via intrinsic and extrinsic pathways
Authors: Chou Pei‐Yu , Lu Ya‐Ting , Sheu Ming‐Jyh 
Published: September 2023

AbstractRestenosis frequently occurs after balloon angioplasty. Percutaneous coronary intervention (PCI)‐induced artery damage is a significant part of triggering restenosis of the vascular smooth muscles (VSMC). This study aimed to study how ethanol extract of Phellinus merrillii (EPM) affected balloon injury‐induced overgrowth of VSMC, indicating neointima formation. Firstly, our results demonstrated that EPM notably decreased VSMC viability. A fragmentation assay and Annexin V/Propidium Iodide apoptosis assay showed that higher doses of EPM significantly induced the apoptosis of VSMC after 24 h of exposure. Total protein extracted from VSMC treated with EPM in various time and concentration periods was then conducted in Western blotting analysis. Our data demonstrated that EPM substantially elevated the p53, p21, Fas, Bax, p‐p38, and active caspase‐3 protein expressions. The results indicated that EPM induces VSMC apoptosis via intrinsic and extrinsic pathways. Also, our results demonstrated that EPM effectively attenuated the balloon injury‐induced neointima formation. In conclusion, the information offers a mechanism of EPM in inducing the VSMC apoptosis, thus as a potential interference for restenosis.
Alpha and theta band activity share information relevant to proactive and reactive control during conflict‐modulated response inhibition
Authors: Pscherer Charlotte , Wendiggensen Paul , Mückschel Moritz , Bluschke Annet , Beste Christian 
Published: September 2023

AbstractResponse inhibition is an important instance of cognitive control and can be complicated by perceptual conflict. The neurophysiological mechanisms underlying these processes are still not understood. Especially the relationship between neural processes directly preceding cognitive control (proactive control) and processes underlying cognitive control (reactive control) has not been examined although there should be close links. In the current study, we investigate these aspects in a sample of N = 50 healthy adults. Time‐frequency and beamforming approaches were applied to analyze the interrelation of brain states before (pre‐trial) and during (within‐trial) cognitive control. The behavioral data replicate a perceptual conflict‐dependent modulation of response inhibition. During the pre‐trial period, insular, inferior frontal, superior temporal, and precentral alpha activity was positively correlated with theta activity in the same regions and the superior frontal gyrus. Additionally, participants with a stronger pre‐trial alpha activity in the primary motor cortex showed a stronger (within‐trial) conflict effect in the theta band in the primary motor cortex. This theta conflict effect was further related to a stronger theta conflict effect in the midcingulate cortex until the end of the trial. The temporal cascade of these processes suggests that successful proactive preparation (anticipatory information gating) entails a stronger reactive processing of the conflicting stimulus information likely resulting in a realization of the need to adapt the current action plan. The results indicate that theta and alpha band activity share and transfer aspects of information when it comes to the interrelationship between proactive and reactive control during conflict‐modulated motor inhibition.
Reservoir operation impacts on streamflow and sediment dynamics in the transboundary river basin, Vietnam
Authors: Bui Thao T. P. , Kantoush Samehahmed , Kawamura Akira , Du Tien L. T. , Bui Nuong Thi , Capell René , Nguyen Ngoc T. , Du Bui Duong , Saber Mohamed , Tetsuya Sumi , Lee Hyongki , Saleh Ali , Lakshmi Venkataraman , Bartosova Alena , Van Binh Doan , Nguyen Binh Quang , Nguyen Tra T. T. 
Published: September 2023

AbstractHuman interventions activities around the world, particularly reservoir operation, have dramatically altered hydrological and sediment regimes in most of the major river basins. In the Mekong River, specifically the Upper Srepok River Basin (USRB) which is a main tributary of the river basin connected to the Mekong Delta's rice bowl and the Tonle Sap Lake's top inland fisheries, there are increasing concerns about the impacts of cascade reservoir operations on downstream streamflow and sediment budgets. Previous studies estimating impacts either relied solely on observed data or did not verify simulations of regulated streamflow. Using a process‐based hydrological model calibrated and validated for both natural and regulated streamflow in the USRB, it was found that the monthly hydrological changes were up to ±20% compared to pre‐dam periods at the most downstream station bordering between Vietnam and Cambodia (i.e., Ban Don station). The basin also experienced a slight decrease (less than 2%) in annual streamflow. Additionally, average and peak suspended sediment concentration decreased significantly in both of the annual and seasonal periods. At the Ban Don station, sediment loads were reduced 140 thousand tons/year (i.e., 15%) compared to pre‐dam period. Most of the changes in streamflow and sediment budgets in the basin were driven by the Buon Tua Srah reservoir, which had the highest degree of regulation in the basin. Therefore, integrated and transboundary water and sediment management, particularly at Buon Tua Srah reservoir, needs to be developed for the sustainability of the river basin.
Oxycodone alleviates mifepristone‐stimulated human endometrial stromal cell injury by activating the Keap1/Nrf2/HO‐1 signaling pathway
Authors: Zhu Aibing , Yao Fei , Shen Mingkun 
Published: September 2023

AbstractBackgroundEndometrial injury is a common disease in women caused by intrauterine inflammation, infections, and endocrine disorders. Human endometrial stromal cells (hEndoSCs) can maintain endometrial homeostasis and play an important role in repairing endometrial injury. Mifepristone, a steroidal anti‐progesterone drug, is widely used in the field of reproductive medicine worldwide. Mifepristone‐induced hEndoSC injury has been used to study endometrial injury in vitro. At present, the pathogenesis and potential regulatory mechanisms of oxycodone in endometrial injury remain unknown.AimsWe aimed to evaluate the functions of oxycodone in mifepristone‐stimulated hEndoSC injury and analyze its potential molecular mechanism.Materials & MethodshEndoSC viability, cytotoxicity, and apoptosis were analyzed using the methyl thiazolyl tetrazolium assay, the lactate dehydrogenase assay, and flow cytometry, respectively. Furthermore, the levels of cleaved‐Caspase3, Keap1, Nrf2, HO‐1, and NQO1 were assessed using reverse transcription quantitative polymerase chain reaction and western blot analysis, and the release of inflammatory cytokines was determined using the enzyme‐linked immunosorbent assay.ResultsWe observed that oxycodone had no adverse effects on hEndoSCs; rather, it protected hEndoSCs against mifepristone‐induced endometrial damage, as confirmed by the enhanced cell viability, reduced number of apoptotic cells, decreased Caspase3 activity and inflammatory cytokine secretion, and increased Keap1/Nrf2/HO‐1 pathway‐related protein expression. In addition, we found that the protective effects of oxycodone on mifepristone‐induced hEndoSC injury were inhibited by ML385 (a Keap1/Nrf2/HO‐1 inhibitor).ConclusionIn summary, we confirmed that oxycodone alleviates mifepristone‐induced hEndoSC injury by activating the Keap1/Nrf2/HO‐1 signaling pathway.
Effects of albiflorin on oxidative stress and inflammatory responses in rats with acute spinal cord injury
Authors: Fang Pengfei , Wang Yi , Sun Fengqi , Lin Haisheng , Zhang Xindong 
Published: September 2023

AbstractIntroductionOxidative stress and inflammatory responses are often the predominant detrimental factors associated with spinal cord injury (SCI). This study investigates the potential therapeutic effects of albiflorin (AF) on alleviating inflammation and oxidative stress in the rat model with SCI.MethodsInitially, the behavior of SCI‐induced rats is examined by Basso−Beattie−Bresnahan score and the inclined plane examination. Then, the immunohistochemical staining of inflammasome‐related protein (for instance, NACHT, LRR, and PYD domains‐containing protein 3, NLRP3) is performed in combination with enzyme‐linked immunosorbent assay (ELISA) of corresponding proinflammatory factors to assess the immunomodulatory effects of AF. Further, the markers involved in oxidative stress are examined by ELISA and western blot analysis analyses.ResultsThese findings indicated that AF could alleviate motor dysfunction and the loss of neuron cells in SCI‐induced rats. Mechanistically, AF could attenuate the inflammatory responses by reducing oxidative stress and activating nuclear erythroid‐related factor 2 (Nrf2)/heme oxygenase‐1 (HO‐1) pathway in SCI rats. Depleting the antioxidant capacity by inhibiting glutathione biosynthesis could counteract the anti‐inflammatory activity of AF in SCI rats.ConclusionsTogether, our data suggested that AF could serve as a potential therapeutic agent against the aggravation of SCI in rats.
Investigating the efficacy of the AMEP Digital Literacies Framework and Guide for adult EAL settings
Authors: Tour Ekaterina , Creely Edwin , Waterhouse Peter , Henderson Michael 
Published: September 2023

AbstractThe importance of digital literacies for adult language learners from migrant and refugee backgrounds has been widely recognized. However, there is relatively limited conceptual and practical guidance for practitioners. To address this concern, we developed a pedagogical framework and a practical guide for teachers in the Adult Migrant English Program in Australia. The conceptual framework brought together four well‐established bodies of scholarly work and formed the four principles for teaching digital literacies: (1) authentic learning contexts, (2) problem‐based learning, (2) strengths‐based approaches, and (4) multidimensional practices. To unpack the framework for practical use, we then developed a guide, which reflected these principles and offered teaching ideas. This paper describes the conceptualization of the pedagogical framework and reports on a multiple case study which sought to gain insight from five English as an Additional Language (EAL) teachers on the efficacy of the framework and guide. The findings suggest that while there was a reasonable level of understanding of the framework and guide and many rich learning experiences were created , in practice some teachers experienced challenges in actuating some principles of the framework. The article concludes with implications for teachers' self‐directed learning with the help of this resource and future research.
Cypate‐loaded hollow mesoporous Prussian blue nanoparticle/hydrogel system for efficient photodynamic therapy/photothermal therapy dual‐modal antibacterial therapy
Authors: Xing Zheng , Dong Bingyu , Zhang Xiaoxiao , Qiu Lin , Jiang Pengju , Xuan Yang , Ni Xinye , Xu Hongbin , Wang Jianhao 
Published: September 2023

AbstractInfectious diseases caused by pathogenic microorganisms are a significant burden on public health and the economic stability of societies all over the world. The appearance of drug‐resistant bacteria has severely blocked the effectiveness of conventional antibiotics. Therefore, developing novel antibiotic‐free strategies to combat bacteria holds huge potential for maximizing validity and minimizing the risk of enhancing bacterial resistance. Herein, a cypate‐loaded hollow mesoporous Prussian blue nanoparticles (Cy‐HMPBs) was built to achieve the PDT/PTT synergistic antimicrobial therapy. The carbomer hydrogel (CH) was combined with the Cy‐HMPBs to form a nanoparticle/hydrogel therapeutic system (Cy‐HMPBs/CH) to reach the goal of local delivery of antimicrobial cargo. The low concentration of Cy‐HMPBs/CH receives over 99% of antimicrobial ability against Escherichia coli and Staphylococcus aureus upon near‐infrared (NIR) irradiation. More importantly, Cy‐HMPBs/CH has favorable biocompatibility and can play therapeutic effects only after laser irradiation, indicating the on‐demand therapy at the targeted region to avert side effects on healthy tissue. This study provides ideas for the design of an antibiotic‐free antimicrobial strategy against infectious diseases.
Effects of correcting metabolic acidosis on muscle mass and functionality in chronic kidney disease: a systematic review and meta‐analysis
Authors: Visser Wesley J. , van de Braak Elma E.M. , de Mik ‐ van Egmond Anneke M.E. , van der Burgh Anna C. , de Roos Nicole M. , Jans Inez , van der Hoef Iris , Olieman Joanne F. , Hoorn Ewout J. , Severs David 
Published: September 2023

AbstractMetabolic acidosis unfavourably influences the nutritional status of patients with non‐dialysis dependent chronic kidney disease (CKD) including the loss of muscle mass and functionality, but the benefits of correction are uncertain. We investigated the effects of correcting metabolic acidosis on nutritional status in patients with CKD in a systematic review and meta‐analysis. A search was conducted in MEDLINE and the Cochrane Library from inception to June 2023. Study selection, bias assessment, and data extraction were independently performed by two reviewers. The Cochrane risk of bias tool was used to assess the quality of individual studies. We applied random effects meta‐analysis to obtain pooled standardized mean difference (SMD) and 95% confidence intervals (CIs). We retrieved data from 12 intervention studies including 1995 patients, with a mean age of 63.7 ± 11.7 years, a mean estimated glomerular filtration rate of 29.8 ± 8.8 mL/min per 1.73 m2, and 58% were male. Eleven studies performed an intervention with oral sodium bicarbonate compared with either placebo or with standard care and one study compared veverimer, an oral HCl‐binding polymer, with placebo. The mean change in serum bicarbonate was +3.6 mEq/L in the intervention group and +0.4 mEq/L in the control group. Correcting metabolic acidosis significantly improved muscle mass assessed by mid‐arm muscle circumference (SMD 0.35 [95% CI 0.16 to 0.54], P < 0.001) and functionality assessed with the sit‐to‐stand test (SMD −0.31 [95% CI −0.52 to 0.11], P = 0.003). We found no statistically significant effects on dietary protein intake, handgrip strength, serum albumin and prealbumin concentrations, and blood urea nitrogen. Correcting metabolic acidosis in patients with CKD improves muscle mass and physical function. Correction of metabolic acidosis should be considered as part of the nutritional care for patients with CKD.
Plant based synthesis of silver nanoparticles, antimicrobial efficiency, and toxicological assessment using freshwater fish (Cyprinus carpio)
Authors: Khan Qaisar , Yousafzai Ali Muhammad 
Published: September 2023

AbstractSilver nanoparticles (AgNPs) are widely used and have various applications, including medicine, electronics, and textiles. However, their increasing use raises concern about their potential environmental impact, particularly on aquatic organisms, such as fish, which are the primary consumers of aquatic environments and can be exposed to AgNPs through various routes. For this purpose, the leaves of the plant species Bellis perennis were used as a reductive agent to convert silver nitrate into AgNPs, to assess its toxicity against fish. Well‐dispersed and undersized AgNPs were obtained and confirmed using analytical techniques, including Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Moreover, the AgNPs have shown significant antibacterial activity against Aeromonas hydrophila (25.71 ± 0.63) and Vibrio harveyi (22.39 ± 0.29). In addition, the toxicity of the obtained AgNPs was assessed by exposing Cyprinus carpio to various concentrations, including 0.06, 0.1, and 0.2 mg/L. The findings revealed that the AgNPs were significantly accumulated in the intestine, followed by the gills, liver, muscles, kidney, and brain. This bioaccumulation led to histological alterations and destruction in the villi of the intestine, regeneration of liver cells, and degeneration of the gill lamella.Research Highlights
Plants based synthesis of AgNPs is mostly considered as eco‐friendly
A significant antibacterial activity was obtained
The plant mediated AgNPs were found less toxic
The AgNPs was profoundly accumulated and causes histological alterations