bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meaningful outcomes for children and their caregivers attending a paediatric brain centre
Authors: Heydenrijk‐Kikkert Myrna A. , Schmidt Ann Katrin K. , Pangalila Robert , De Wit Marie‐Claire Y. , van Haren Neeltje E. M. , Van Veelen Marie‐Lise C. , Roebroeck Marij E. 
Published: April 2023

AbstractAimTo identify meaningful outcomes of children and their caregivers attending a paediatric brain centre.MethodWe compiled a long list of outcomes of health and functioning of children with brain‐related disorders such as cerebral palsy, spina bifida, (genetic) neurodevelopmental disorders, and acquired brain injury. We incorporated three perspectives: patients, health care professionals, and published outcome sets. An aggregated list was categorized using the International Classification of Functioning, Disability, and Health: Children and Youth version in a patient validation survey for children and parent‐caregivers to prioritize outcomes. Outcomes were considered meaningful when ranked ‘very important’ by 70% or more of the participants.ResultsWe identified 104 outcomes from the three perspectives. After categorizing, 59 outcomes were included in the survey. Thirty‐three surveys were completed by children (n = 4), caregivers (n = 24), and parent‐caregivers together with their child (n = 5). Respondents prioritized 27 meaningful outcomes covering various aspects of health and functioning: emotional well‐being, quality of life, mental and sensory functions, pain, physical health, and activities (communication, mobility, self‐care, interpersonal relationships). Parent‐caregiver concerns and environmental factors were newly identified outcomes.InterpretationChildren and parent‐caregivers identified meaningful outcomes covering various aspects of health and functioning, including caregiver concerns and environmental factors. We propose including those in future outcome sets for children with neurodisability.What this paper adds

Outcomes that children with brain‐related disorders and their parent‐caregivers consider to be the most meaningful cover a wide range of aspects of functioning.

Involving these children and their parent‐caregivers resulted in the identification of important outcomes that were not covered by professionals and the literature.

Parent‐caregiver‐related factors (coping, burden of care) and environmental factors (support, attitudes, and [health care] services) were identified as meaningful.
Potential distribution of Melanagromyza sojae in South America and current situation in Argentina
Authors: Fadda L. A. , Murúa M. G. , Casmuz A. S. , Vera M. A. , Lira‐Noriega A. 
Published: April 2023

AbstractThe Asian soybean stem borer Melanagromyza sojae (Zehntner) (Diptera: Agromyzidae) represents a threat to soybean and chickpea crops in South America. It is known that in the region its population has increased, in part, due to the difficulty in its agronomic management. This is due to the lack of knowledge regarding its biology and the environments that are favorable for its establishment. In this study, we provide a comprehensive database of records of M. sojae, as well as an updated list of its host plants from field surveys, bibliographic review, and online databases. We estimated the suitability and potential distribution of the pest considering environmental information from remote sensors and bioclimatic variables and contrasted these against land‐use cover across South America. In Argentina, M. sojae was found developing on Tithonia tubaeformis (Jacq.) Cass. (Asteraceae), surviving in chickpeas and volunteer soybeans that were affected by winter frost. The most informative models and highest suitability were predicted from vegetation indices and bioclimatic variables, and coincided with sites having a high proportion of arable land. Regarding climate, the greatest suitability occurred in eastern South America, including the southern states of Brazil and Paraguay, where the final models recovered the current known distribution of the species on the continent. However, its extension may be even greater than predicted, due to the wide distribution range of its hosts. This characterization of suitability for M. sojae could be a useful resource to anticipate the regions that are most favorable for its presence and supports the need to consider the distribution of crops and host plants that could act as natural reservoirs to identify sites and streamline efforts to reduce the incidence of the pest.
An interpretable diagnostic approach for lung cancer: Combining maximal clique and improved BERT
Authors: Chen Zi‐yu , Xiao Fei , Wang Xiao‐kang , Hou Wen‐hui , Huang Rui‐lu , Wang Jian‐qiang 
Published: April 2023

AbstractThe lung cancer incidence and mortality in China have always been high. Moreover, due to the limited level of professional technology, misdiagnosis and missed diagnosis of lung cancer often occur. To improve the accuracy of diagnosis, this paper proposes an interpretable diagnostic method for lung cancer based on Chinese electronic medical records (EMRs). First, to overcome the difficulty in word segmentation of clinical texts in Chinese EMRs, a dictionary construction method is proposed based on the idea of maximal clique, and 730 medical professional terms related to lung diseases are identified. Then, the ProbSparse self‐attention mechanism and self‐attention distilling operation in Informer are used to improve the Bidirectional Encoder Representations from Transformer (BERT) to realize the representation of long clinical texts with lower time complexity and memory consumption. Finally, the convolutional neural network with an attention mechanism is employed to process the representation results to realize the interpretable prediction of lung cancer. This method is applied to the lung cancer diagnosis of inpatients in a tertiary hospital in Hunan Province, obtaining excellent results of about 0.9 for area under the receiver operating characteristic curve (AUROC) and area under the precision‐recall curve (AUPRC). In addition, the results of the comparative analysis with existing dictionaries, word embedding methods and diagnostic methods further confirm the superiority of the proposed method. Specifically, the proposed method improves the precision by at least 6%, the recall by at least 2.6%, the F1 score by at least 5.2%, AUROC by at least 7.3% and AUPRC by at least 7.7% compared with all these state‐of‐the‐art methods.
We get by with family: Maternal partnership transitions and extended kin coresidence
Authors: Williams Heidi M. 
Published: April 2023

AbstractObjectiveThis study examines the extent to which mothers coreside with extended kin during partnership transitions.BackgroundParental relationship changes are increasingly common, especially among unmarried parents. Although research shows that families often coreside out of economic necessity, extended kin coresidence as a function of maternal relationship changes has not been explored. Using life course theory, this study examines where and with whom mothers and their children live during partnership transitions.MethodData are from 2,886 mothers who participated in the Future of Families and Child Wellbeing Study. Bivariate and multinomial logistic regression, random effects, and fixed effects models were estimated to determine if mothers' coresidential relationships with extended kin were formed by changes in mothers' coresidential romantic partnership statuses.ResultsMothers' partnership changes were associated with extended kin coresidence, especially among unmarried mothers. By Year 9, mothers were more likely to live “elsewhere.” Mothers' parity and multipartnered fertility decreased their chances of living with extended kin.ConclusionThis study indicates that maternal relationship changes provoke family instability and reliance on extended kin. Mothers' transitions contribute to “network fatigue” and homelessness.ImplicationsHousing support for mothers may mitigate instability associated with maternal relationship transitions and protect extended kin against transitions.
True insights or ticking boxes? Rapid assessment of rights‐based management in artisanal fisheries
Authors: Cisneros‐Montemayor Andrés M. , Aceves‐Bueno Eréndira , Amezcua‐Castro Sergio , Apolinar‐Romo Alejandra , Cisneros‐Soberanis Frida , Cuevas‐Gómez Gabriela A. , Cruz‐León Ingrid C. , De La Cruz‐González Javier , Espinoza‐Tenorio Alejandro , García‐Lozano Alejandro , González‐Espinosa Pedro C. , Cisneros‐Mata Miguel A. 
Published: April 2023

AbstractRights‐based fisheries management (RBFM) seeks to create market incentives to reduce competition, avoid overexploitation, and increase economic efficiency. Particularly for artisanal fisheries, however, assumptions of RBFM may not be met and its use needs to be carefully considered. This study applies an existing tool (SEASALT) to evaluate the strength of RBFM based on attributes of security, exclusivity, fish mortality, scale, responsibility, limitations, and transferability. Results for 17 fisheries in Mexico show a positive (nonsignificant) relationship between the strength of RBFM and stock status, and no effect on prices or landed value. Real‐world fisheries governance systems are much more complex than the simple linkages between attributes implied in SEASALT, but results highlight pre‐existing monitoring and enforcement capacity as essential for successful RBFM. Transitions to RBFM may strengthen this capacity, but likely cannot create it where it does not already exist. Based on our findings, RBFM strategies may benefit from group quotas with limited transferability to avoid negative social outcomes from consolidation or rent capture by intermediaries; this could potentially build on the latent capacity of traditional community associations common in many artisanal fisheries.
Charter school proliferation and school district fiscal stress, a chicken‐egg problem
Authors: Feng Bo 
Published: April 2023

AbstractCharter schools have become one of the most popular school choice programs in recent years. While being accused of endangering the fiscal health of local school districts, charter school proliferation could also be the result of fiscal stress of local school districts. However, this reverse causation has not been fully studied in the literature. Using data of local school districts in Ohio from 2011 to 2019, I adopt an Instrumental Variable approach to investigate the possible scenario that the rapid growth in charter school enrollment could be caused by fiscal stress of school districts. The results suggest that the inadequate funding from state and local sources had led to a significant increase in charter school enrollment for urban districts, although the charter demand is inelastic to public funding changes. Students could be left with no better options but to choose charter schools over failing traditional public schools.
A qualitative study exploring the benefits of involving young people in mental health research
Authors: Watson Rebecca , Burgess Lowrie , Sellars Elise , Crooks Jodie , McGowan Rose , Diffey James , Naughton Georgia , Carrington Rebekah , Lovelock Cassie , Temple Rachel , Creswell Cathy , McMellon Christina 
Published: April 2023

AbstractIntroductionIt is increasingly accepted that young people need to be centrally involved in research on issues that affect them. The aim of this study was to explore young people's perceptions of the benefits for them of being involved in mental health research and the processes that enabled these benefits.MethodsQualitative interviews were conducted by co‐researchers (young people with lived experience and/or interest in mental health) with 13 young people (aged 13–24 years) who had experience of being involved in mental health research when they were between 11 and 16 years of age. Reflective thematic analysis was used to identify important aspects of young people's experiences.ResultsFour main themes were identified: (1) opportunity to have a meaningful impact, (2) opportunity to be part of a supportive community, (3) opportunity to learn and grow and (4) increasing opportunities for young people.ConclusionThis study highlights young people's experiences of being involved in mental health research and identifies ways in which researchers can ensure that involvement opportunities bring benefits to both the young people and the research.Patient or Public ContributionThis research was a response to issues raised by young people involved in research. The project was supported by co‐researchers throughout, including design, data collection, analysis and write‐up.
Impact of the COVID‐19 pandemic on melanoma diagnosis and presentation: a `review
Authors: Fanning James E. , Kalsi Simran , Krag David N. 
Published: April 2023

AbstractThe ongoing challenges posed by COVID‐19 are concerning for their impact on successful detection and recognition of melanoma as total body skin examinations and skin biopsies are critical for identifying early‐stage melanoma and intervening before progression to metastatic disease. A comprehensive electronic search of PubMed/MEDLINE was conducted on or before August 1, 2022, using the search terms (“skin” AND “COVID‐19”), ([“skin cancer” AND “COVID‐19”] OR [“skin cancer” AND “coronavirus”]), ([“melanoma” AND “COVID‐19”] OR [“melanoma” AND “coronavirus”]), (“dermatology” AND “COVID‐19”), and (“cutaneous” AND “COVID‐19”). Eight articles representing Belgium, Chile, France, Germany, Spain, the United Kingdom, and the United States were included. Four articles analyzed changes in the proportion of in situ melanoma at diagnosis and consistently reported decreases, with an overall decrease ranging from 7.6 to 40.4%. Five studies analyzed changes in the proportion of melanoma diagnoses by staging, but no clear changes in staging patterns were observed. Five studies analyzed changes in the mean Breslow thickness of melanoma diagnoses and consistently reported increases, with an overall increase ranging from 4.0 to 38%. Disruptions to proper diagnosis and treatment of melanoma are creating undue morbidity, mortality, and healthcare costs as the pandemic continues. Continued research with improved, centralized data collection is needed to better address the COVID‐19 pandemic's ongoing challenge to appropriate detection and treatment of melanoma.
A review of alternative plant protein sources, their extraction, functional characterisation, application, nutritional value and pinch points to being the solution to sustainable food production
Authors: Munialo Claire D 
Published: April 2023

SummaryProteins from animal sources have for many centuries been used as the conventional food proteins in the food industry to produce a variety of food products. This is mainly attributed to their functional properties that range from foaming ability and stability to emulsification and gelation. However, animal husbandry has a greater impact on the environment compared to crop production. Thus, research on the potential use of plant‐based proteins, which could be more sustainable, cheaper and environmentally friendly has continued to be the focus of many academics and the food industry. Even though studies have been carried out to investigate the functional properties of plant‐based protein sources, there is still a need to understand the challenges that exist in the extraction and the functional characteristics of proteins from plant sources, which could be used as a more feasible exchange for animal‐based proteins. Therefore, this review aims to contribute to the existing knowledge on the extraction, characterisation and functional properties of plant‐based proteins. To this end, relevant literature was searched on several databases such as EBSCO HOST and Science Direct. Google Scholar was also used as a complementary search engine. Research that has addressed the extraction and functional characterisation of proteins from plant sources was critically evaluated and the findings are discussed herein. Additionally, the pinch points that exist in the use of plant‐based proteins as alternatives to animal proteins in food processing are highlighted in this review.
M2‐like macrophages polarized by Foxp3−Treg‐of‐B cells ameliorate imiquimod‐induced psoriasis
Authors: Huang Jing‐Hui , Lin Yu‐Li , Wang Li‐Chieh , Chiang Bor‐Luen 
Published: April 2023

AbstractOur group have demonstrated that splenic B cells contributed to the CD4+CD25− naive T cells conversion into CD4+CD25+Foxp3− regulatory T cells without adding appended cytokines, named Treg‐of‐B cells which were potent suppressors of adaptive immunity. We like to investigate whether Treg‐of‐B cells could promote alternatively activated macrophage (M2 macrophages) polarization and alleviate inflammatory disease, psoriasis. In this study, we co‐cultured the bone marrow‐derived macrophages (BMDMs) with Treg‐of‐B cells under LPS/IFN‐γ stimulation and analyzed the M2‐associated gene and protein using qPCR, western blotting, and immunofluorescence staining. We also examined the therapeutic effect of Treg‐of‐B cell‐induced M2 macrophage for skin inflammation using imiquimod (IMQ)‐induced psoriatic mouse model. Our results showed that BMDMs co‐cultured with Treg‐of‐B cells upregulated typical M2‐associated molecules, including Arg‐1, IL‐10, Pdcd1lg2, MGL‐1, IL‐4, YM1/2 and CD206. In an inflammatory environment, TNF‐α and IL‐6 production by macrophages co‐cultured with Treg‐of‐B cells was decreased significantly. The molecular mechanism revealed that Treg‐of‐B cells promoted M2 macrophage polarization via STAT6 activation in a cell contact‐dependent manner. Moreover, the treatment with Treg‐of‐B cell‐induced M2 macrophages attenuated the clinical manifestations of psoriasis, such as scaling, erythema and thickening in the IMQ‐induced psoriatic mouse model. T cell activation in draining lymph nodes was decreased in the Treg‐of‐B cell‐induced M2 macrophage group after IMQ application. In conclusion, our findings suggested that Foxp3− Treg‐of‐B cells could induce alternatively activated M2 macrophages through STAT6 activation, providing a cell‐based therapeutic strategy for psoriasis.
Parental effects on inbreeding depression in a beetle with obligate parental care
Authors: Hughes Parker , Rudman Lucille J. , Schrader Matthew 
Published: April 2023

Abstract
Inbreeding depression occurs when individuals who are closely related mate and produce offspring with reduced fitness. Although inbreeding depression is a genetic phenomenon, the magnitude of inbreeding depression can be influenced by environmental conditions and parental effects. In this study, we tested whether size-based parental effects influence the magnitude of inbreeding depression in an insect with elaborate and obligate parental care (the burying beetle, Nicrophorus orbicollis). We found that larger parents produced larger offspring. However, larval mass was also influenced by the interaction between parental body size and larval inbreeding status: when parents were small, inbred larvae were smaller than outbred larvae, but when parents were large this pattern was reversed. In contrast, survival from larval dispersal to adult emergence showed inbreeding depression that was unaffected by parental body size. Our results suggest that size-based parental effects can generate variation in the magnitude of inbreeding depression. Further work is needed to dissect the mechanisms through which this might occur and to better understand why parental size influences inbreeding depression in some traits but not others.
Abstract
We tested whether parental body size influenced the magnitude of inbreeding depression in an insect with obligate parental care (Nicrophorus orbicollis). We found that when parents were small, inbred larvae were smaller than outbred larvae. This pattern was reversed with parents who were large. In contrast, survival to eclosion displayed inbreeding depression that was insensitive to parental size.
Microstructural features, physicο‐mechanical properties, and wear behavior of dental translucent polychromic multilayer zirconia of hybrid composition prepared by milling technology
Authors: Dimitriadis Konstantinos , Constantinou Marios , Moschovas Dimitrios , Constantinides Georgios , Agathopoulos Simeon 
Published: April 2023

AbstractObjectiveThe present study determined the mechanical properties and the wear behavior, as results of the micro(nano)structure, of the enamel, transition, and dentine layers, which comprise the polychromic multilayer zirconia materials of hybrid composition fabricated by milling technology.Materials and MethodsPrismatic blocks were fabricated from two commercial pre‐sintered dental polychromic multilayer zirconia materials of hybrid composition, IPS e.max ZirCAD Prime (medium and high translucency, from the dentine to the incisal layer) and 3D Pro ML (translucency gradient, from the dentine to the incisal layer) by milling technique, and then, cut into 3 distinct parts to separate the enamel, transition, and dentine layers. The samples were sintered, thermally treated (similarly to the glazing procedure), and polished for characterization. Their microstructure, mechanical properties (determined by nanoindentation and microhardness), and wear behavior (evaluated by scratch test), were examined.ResultsThe produced materials had a homogeneous and dense nanostructure, where the grain size decreased from the enamel to dentine layer. The mechanical properties decreased from the dentine to enamel layer. However, the three layers manifested similar dynamic friction coefficient.ConclusionThe differences in the above properties in the three layers negligibly influenced the wear behavior of the entire multilayer zirconia material.Clinical SignificanceThe properties of dental restorations produced from polychromic multilayer zirconia of hybrid composition by milling technology (i.e., strong, non‐fragile, and esthetic materials), anticipate good performance in oral cavity.
Effect of cross‐polarization filters on the trueness of colors obtained with a single‐lens reflex camera, macro lens, and a ring flash
Authors: Yilmaz Burak , Dede Doğu Ömür , Diker Emre , Fonseca Manrique , Johnston William Michael , Küçükekenci Ahmet Serkan 
Published: April 2023

AbstractObjectiveTo investigate the effect of cross‐polarization filters on the colors of shade tabs obtained with a digital single‐lens reflex (DSLR) camera, macrolens, and a ring flash.Materials and MethodsDigital images of four shade tables (1M1, 3L2.5, 3R2.5, and 5M3) from the VITA Toothguide 3D‐Master shade guide were taken using a DSLR camera, 100 mm macrolens, and ring flash with two different cross‐polarizing filters (Polar_eyes and Filtropolar), and without (Nonpolarizer; n = 7). The CIE L*a*b* color coordinates of digital images were calculated and remeasured with a spectroradiometer (SR). The color differences (ΔE00) between the SR and digital images were calculated and analyzed with the two‐way analysis of variance (ANOVA) and Tukey HSD test (α = 0.05).ResultsΔE00 values of all test groups were higher than the clinically acceptable threshold (∆E00 > 1.80). While the ∆E00 values of Filtropolar (6.19 ± 0.44) and Polar_eyes (7.82 ± 0.23) groups were significantly higher than the Nonpolarizer (4.69 ± 0.32) for the 1M1 shade tab, ∆E00 value of Polar_eyes (6.23 ± 0.34) was significantly lower than Nonpolarizer (10.71 ± 0.48) group for 5M3 shade tab (p < 0.05).ConclusionThe color‐matching results of tested digital photography techniques with and without cross‐polarization were unacceptable, compared to a spectroradiometer. While digital photography with Polar_eyes cross‐polarizing filter has closer results to the reference device for the low‐in‐value shade table (5M3), for the high‐in‐value shade table (1M1), improved results were obtained without a cross‐polarizing filter.Clinical SignificanceThe cross‐polarization filters are increasingly used in dentistry for tooth color communication with digital photography techniques. However, the digital photography techniques with‐without cross‐polarization filterers should be improved to obtain clinically acceptable color‐matching results.