bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disulfidptosis-related NCK associated protein 1 as a potential biomarker for multiple tumor types: A pan-cancer analysis based on public databases
Authors: Cao Qian , Hong Aonan , Shen Ruizhi , Wang Chunhui , Liang Xiao 
Published: June 2023

Abstract
In the past decade, a number of cancer types have been reported to be associated with NCKAP1 encoded as a component of the WASF regulatory complex (WRC) and a poor prognosis. A study of the role of NCKAP1 across various types of tumors was conducted using data from The Cancer Genome Atlas (TCGA). There was an alteration in NCKAP1 expression in most tumor types when compared to corresponding non-tumor tissues. Survival analysis revealed that NCKAP1 overexpression was associated with poor OS and DFS only in kidney renal clear cell carcinoma (KIRC), and upregulated NCKAP1 expression was also significantly associated with the advanced cancer stage suggesting malignant progression in KIRC based on TCGA datasets using GEPIA2; Meanwhile, IHC staining showed NCKAP1 levels of KIRC tissues were significantly lower than normal tissues from HPA database. Following that, NCKAP1 alteration was associated with poor prognosis in cervical squamous cell carcinoma (CSCC) and lung adenocarcinoma (LUAD) patients in terms of PFS analyzed by cBioPortal. As a result, a positive correlation was observed between NCKAP1 expression and cancer-associated fibroblast infiltration in ACC, BRCA, CESC, LGG, and STAD. According to Gene Ontology analysis, NCKAP1 encodes a gene that regulates the actin cytoskeleton function. It was demonstrated from the protein interaction network that NCKAP1 interacts physically with CYFIP1, ABI2, WASF2 and BRK1, which have been well-characterized as actin cytoskeleton cycle regulators and cell disulfidptosis. There was a significant correlation between NCKAP1 expression and tumor prognosis in this multi-tumor study.
Robotic exoskeleton embodiment in post-stroke hemiparetic patients: an experimental study about the integration of the assistance provided by the REFLEX knee exoskeleton
Authors: Lora-Millan Julio S. , Sanchez-Cuesta Francisco José , Romero Juan Pablo , Moreno Juan C , Rocon Eduardo 
Published: June 2023

Abstract
Hemiparetic gait is the most common motor-disorder after stroke and, in spite of rehabilitation efforts, it is persistent in 50% of community dwelling stroke-survivors. Robotic exoskeletons have been proposed as assistive devices to support impaired joints. An example of these devices is the REFLEX knee exoskeleton, which assists the gait of hemiparetic subjects and whose action seems to be properly embodied by stroke survivors, who were able to adapt the motion of their non-assisted limbs and, therefore, reduce their compensation mechanisms. This paper presents an experimental validation carried out to deepen into the effects of REFLEX's assistance in hemiparetic subjects. Special attention was paid to the effect produced in the muscular activity as a metric to evaluate the embodiment of this technology. Significant differences were obtained at the subject level due to the assistance; however, the high dispersion of the measured outcomes avoided extracting global effects at the group level. These results highlight the need of individually tailoring the action of the robot to the individual needs of each patient to maximize the beneficial outcomes. Extra research effort should be done to elucidate the neural mechanisms involved in the embodiment of external devices by stroke survivors.
Analysis of hot research topics on environmental migration in a just transition
Authors: Liang Bing , Shi Guoqing , Hua Yinjie , Ye Taotao , Su Yu , Lu Zhongman 
Published: June 2023

Abstract
Global environmental issues have become one of the most prominent risk issues in society, and it is of great theoretical and practical importance to study the intrinsic correlation between environmental change and population migration in a just transition. Based on the Web of Science core ensemble database (WOS) and National Knowledge Infrastructure database (CNKI) sources, CiteSpace visual bibliometric software was used to construct a map of research hotspots in the field of environmental migration. The study found that the research hotspots of environmental migration mainly include (1) migration caused by environmental pollution; (2) migration caused by the construction of environmental protection projects; (3) migration caused by environmental protection activities; (4) migration caused by environmental degradation; (5) migration caused by climate change; (6) migration caused by environmental disasters; and (7) migration caused by environmental improvement activities. We propose the following recommendations for environmental migration research: (1) strengthen research on the predictive capability of environmental change-population migration models; (2) make use of China's useful exploration in resettlement fields such as engineering resettlement, ecological migration, and poverty alleviation resettlement to develop environmental migration policies and regulations and strategic planning; (3) establish a cloud platform for environmental changes and population migration-related databases; and (4) strengthen the exchange and cooperation between Chinese research scholars in the field of environmental migration and international research institutions.
The assessment of probabilistic seismic risk using ground-motion simulations via a Monte Carlo approach
Authors: Rudman Archie John , Douglas John , Tubaldi Enrico 
Published: June 2023

Abstract
Accurately characterizing ground motions is crucial for estimating probabilistic seismic hazard and risk. The growing number of ground motion models, and increased use of simulations in hazard and risk assessments, warrants a comparison between the different techniques available to predict ground motions. This research aims at investigating how the use of different ground-motion models can affect seismic hazard and risk estimates. For this purpose, a case study is considered with a circular seismic source zone and two line sources. A stochastic ground-motion model is used within a Monte Carlo analysis to create a benchmark hazard output. This approach allows the generation of many records, helping to capture details of the ground-motion median and variability, which a ground motion prediction equation may fail to properly model. A variety of ground-motion models are fitted to the simulated ground motion data, with fixed and magnitude-dependant standard deviations (sigmas) considered. These include classic ground motion prediction equations (with basic and more complex functional forms), and a model using an artificial neural network. Hazard is estimated from these models and then we extend the approach to a risk assessment for an inelastic single-degree-of-freedom-system. Only the artificial neural network produces accurate hazard results below an annual frequency of exceedance of 1x10− 3 years− 1. This has a direct impact on risk estimates - with ground motions from large, close-to-site events having more influence on results than expected. Finally, an alternative to ground-motion modelling is explored through an observational-based hazard assessment which uses recorded strong-motions to directly quantify hazard.
Responding to Human Trafficking among Refugees: Prevalence and Test Accuracy of a Modified Version of the Adult Human Trafficking Screening Tool
Authors: Stollwerck Estella Alejandra Tambini , Rollmann Ivo , Friederich Hans-Christoph , Nikendei Christoph 
Published: June 2023

Abstract
Background: Human trafficking is a human rights violation and urgent public health challenge. It involves the exploitation of a person by means of force, intimidation or deceit and causes severe health risks. Thoughit occurs all over the world, its true extent is still unknown. Refugees are especially vulnerable to human trafficking due to language barriers and difficult living conditions. Therefore, the purpose of this study was to design a screening tool to identify survivors of human trafficking among refugees in a German state registration and reception centre.
Methods: In cooperation with the local authorities, we asked newly arrived refugees at an initial reception centre in Southern Germany about their experiences with human trafficking. We used a combination of the Adult Human Trafficking Screening Tool and a publication by Mumma et al. to address all forms of exploitation. The results were cross-checked by a short interview afterwards.
Results: In total, 13 of the 176 asylum seekers had experienced trafficking, which corresponded to a prevalence of 7.3%. The questionnaire had a sensitivity of 76.9% and a specificity of 84.0% at a newly selected cut-off of six positive responses. In an exploratory descriptive analysis on subregions, refugees from West Africa had a substantially higher prevalence (33.3%) for human trafficking within our sample, especially women. However, when we excluded this region from our analysis, we found no significant gender difference for the rest of the sample.
Conclusions: The screening tool distinguishes reliably those who had experienced human trafficking from other refugees. The high prevalence of trafficking in most regions, regardless of gender, suggests that more effort is needed to identify and protect all trafficked persons.
Identification and molecular characterization of a novel species of the genus Totivirus from Areca catechu L.
Authors: Huang Xi , Tan Hang , Zhao Ruibai , Wang Hongxing 
Published: June 2023

Abstract
In previous work, RNA-seq was applied to identify the causal agent of yellow leaf disease (YLD) of areca palm (Areca catechu L.), besides a YLD related areca palm velarivirus 1 (APV1), a totivirus-like virus annotated as Panax notoginseng virus A (PnVA) was identified. Because the virus was also detected in many asymptomatical areca palm, it was therefore tentatively named Areca palm latent virus 1 (APLV1). The complete sequence of APLV1 was determined to be 4754 base pairs (bp) in length. Two deduced proteins encoded by APLV1 have 55% and 69 % amino acid (aa) sequence identity with CP and RNA-dependent RNA polymerase (RdRp) of Bursera graveolens associated totivirus 1 (BgAT1), respectively. Phylogenetic analysis based on alignment of the CP and RdRp sequences clustered APLV1 with other members of the genus Totivirus, suggesting that APLV1 might be a novel species of the genus Totivirus, family Totiviridae.
Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy
Authors: Liu Di , Song Yanling , Chen Hui , You Yuchan , Zhu Luwen , Zhang Jucong , Xu Xinyi , Hu Jiahao , Huang Xiajie , Wu Xiaochuan , Xu Xiao-Ling , Jiang Saiping , Du Yong-Zhong 
Published: June 2023

Abstract
Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepared F(ab′)2 fragmented vascular endothelial growth factor receptor 2 antibody (anti-VEGFR2 (F(ab′)2) to block VEGFR2 overactivation in diabetic nephropathy (DN). We found that the anti-VEGFR2 F(ab′)2 had a higher accumulation in DN mice kidneys and a comparable VEGFR2 combination with the intact VEGFR2 antibody. Furthermore, we developed an antibody fragment drug conjugate, anti-VEGFR2 F(ab′)2-SS31, comprising anti-VEGFR2 F(ab′)2 fragment linked to the mitochondria-targeted antioxidant peptide SS31. We found that introduce of SS31 potentiated the efficacy of anti-VEGFR2 F(ab′)2. These findings provide proof of concept for the premise that antibody fragment drug conjugate improves renal distribution and merits drug validation in renal disease therapy.
Hybrid tape versus synthetic tape in treatment of female stress urinary incontinence .A prospective clinical study
Authors: Mansy Islam , Elsayed Diab , saafan ahmed , Abouhashem Safwat E , Taha Kareem M , Samaha Ibrahem Ismael , Eliwa Ahmed M 
Published: June 2023

Abstract
Objective:
To compare the clinical and operative outcomes of hybrid tape versus synthetic tapes during mid-urethral sling in treating female stress urinary incontinence (SUI).
Patients and methods:
This prospective study included 60 women with SUI. Patients were categorized into two groups: Group I included 30 patients who underwent midurethral sling procedure using hybrid tape; and Group II included 30 patients that had synthetic sling, using trans obturator tape approach (TOT) in both groups . The following variables were compared: operative time, post operative pain scores, duration of indwelling urethral catheter, hospital stay, and QoL assessment (International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form [ICIQ-UI-SF]) before and after discharge from hospital.
Results:
Patients among the two groups were normally distributed with no statistically significant difference in patient’s demographic data and comorbidities. There was an obvious increase in operative time in group I compared to group II. This increase was statistically highly significant. (p <0.001).
Conclusion:
Hybrid tape should be considered as a treatment option during TOT for female SUI with comparable efficacy and safety to synthetic tape. Long term follow up should be considered.
Subject classification codes: include these here if the journal requires them
Characteristics analysis of chloroplast genome and molecular evolution of chloroplast genes in Amaryllidaceae plants
Authors: Chen Dan , Fu Chun 
Published: June 2023

AbstractBackgroundAmaryllidaceaeis a family of Monocotyledons inLiliflorae, and is considered an important ornamental and economic plant due to its usually showy flowers, and theAmaryllidaceaealso has enormous medicinal value. Currently, the gene structure characteristics and molecular function analysis of all chloroplast genomes inAmaryllidaceaeare rarely reported, so this study mainly analyzed the gene structure characteristics and molecular function of all chloroplast genomes inAmaryllidaceaeto reveal the characteristics of the chloroplast genome ofAmaryllidaceaeplants and explore their evolution and development patterns, and it usedbioinformaticsmethods to analyze the chloroplast genome sequences of 64Amaryllidaceaeplants that have been published on NCBI. Results Among the 64 species ofAmaryllidaceaeplants, the species with a gene number of 86 had the most chloroplasts, with 38 species accounting for approximately 59%. The number of rRNAs in its chloroplast genome is all 8. There are 55 species of plants in theAmaryllidaceaewith 38 tRNAs, and only a few species have abnormal tRNA numbers in their chloroplast genomes due to the loss or duplication of tRNA genes. The GC content of chloroplast genomes in all species ranges from 36–39%, indicating that their AT content is roughly between 61–64%. The high proportion of AT content in chloroplast genomes indicates that chloroplast codons prefer to use A/T bases. By constructing a phylogenetic evolution tree, it was found that the 64 species ofAmaryllidaceaeplants can be divided into 12 evolutionary groups.Lycoris longitubaandLycoris anhuiensishave the fastest evolutionary speed, whileAllium przewalskianumandAllium polyrhizum CMS-Shave the most primitive and slowest evolutionary speed. By analyzing the codon preference of chloroplast genomes, it was found that plants in theAmaryllidaceaeprefer to use synonymous codons ending in A/U, and their chloroplast genome codon usage bias is weak. Conclusion Our results preliminarily explored the relationship between each species in Amaryllidaceae, and the characteristics of the entire chloroplast genome sequence ofAmaryllidaceaewere revealed, these results provide a certain theoretical basis for further research on the plants of theAmaryllidaceaefamily in the future.
Comparison of diagnostic ability of new blood endotoxin measurement method using leukocyte-rich plasma sample and existing sepsis markers
Authors: Yoshinao Daisuke , Takahashi Gaku , Nonoguchi Maria , Kan Shigenori , Inada Katsuya , Mase Tomohiko 
Published: June 2023

Abstract
The plasma sample, which contains almost no leukocytes, is generally used to measure endotoxin levels in blood. However, it is known that the diagnostic ability is not high. We assumed that most endotoxins exist in a state trapped by leukocytes, and then we have devised a method (LRP37 method) to obtain leukocyte-rich plasma (LRP) for measuring blood endotoxins. In this study, we selected the following two methods for measuring endotoxins in the LRP; the conventional turbidimetric kinetic assay (TKA) and the semi-automated luminescent substrate method (SALS) using the leukocyte fraction obtained the LRP. The endotoxin levels obtained from these methods were compared with the diagnostic ability of existing sepsis markers. The target cases were 40 who were admitted to our institution. Comparing the non-infected group with the Gram-negative infected group, the area under the curve of TKA and SALS were 0.94 and 0.86, respectively, and these diagnostic capabilities were the best among all the markers tested.
Assessment of the synthesis method for purity and particle size of Fe3O4 magnetic nanocatalysts and its effectiveness on viscosity reduction and upgrading of heavy oil
Authors: Torkaman Parya , Karimzadeh Ramin , Jafari Arezou 
Published: June 2023

Abstract
In this research, Fe3O4 nanocatalysts were synthesized systematically microwave-assisted. For the first time, the efficiency of the synthesized nanocatalysts in reducing viscosity and upgrading heavy oil was examined. The nanocatalysts were investigated for their magnetic and electromagnetic properties. Furthermore, the effect of the time and power of microwave radiation was investigated for the first time on the size and purity of nanocatalysts. By reducing the time and power of microwave radiation due to less heat production, the purities in the crystal network of Fe3O4 nanocatalysts expanded. Increased temperature leads to dope NH4Cl into the Fe3O4 crystal network. At: 1 minute and power of 400 watts had the most satisfactory results in the size and purity of nanocatalysts. For the first time, the effect of the synthesis method on the electromagnetic properties, size, and effectiveness of the synthesized Fe3O4 has been examined. The performance of Fe3O4 synthesized by co-precipitation and microwave in viscosity reduction and heavy oil upgrading was evaluated and compared. The crystallite size of the Fe3O4 synthesized with microwave-assisted was smaller than synthesized by the co-precipitation. Fe3O4 synthesized by microwave and the co-precipitation method lead to decreased viscosity by 28% and 23% respectively. Also, microwave-synthesized Fe3O4 reduced the sulfoxide index and aromatic index significantly more than the co-precipitated synthesized Fe3O4 (90% vs. 48% and 13% vs. 7%, respectively).
A 51-year-old man who presented with acute onset aphasia, right sided weakness - Case Report
Authors: Singh Shivangi , Mehta Amol , Kumar Aditya , Gutierrez Jose D. , Marshall Randolph S. , Spektor Vadim , Park Soojin 
Published: June 2023

Abstract
Introduction
Acute internal carotid artery (ICA) occlusions have a precise differential, of which includes Eagle’s Syndrome, which is due to disfigured or elongated styloid processes. This can result in 1) unilateral oropharyngeal, facial and auricular pain due to irritation of the glossopharyngeal nerve or 2) carotid artery dissection. In this report, we highlight the diagnostic/management approach to the latter.
Case Presentation
A 51-year-old man presented with acute onset aphasia and right sided weakness, was found to have a L ICA occlusion and on further review to have a R ICA occlusion in the past. Ultimately, workup was consistent with bilateral carotid artery dissections – Eagle’s Syndrome.
Conclusions
Bilateral Eagle’s Syndrome is an extremely care condition, and this case report highlights the diagnostic/management considerations, especially as it relates to the utilization of multiple imaging modalities.
Novel ensemble models and their optimization based flood susceptibility modelling in Indian Himalayan Foreland Basin
Authors: Pandey Manish , Costache Romulus , Dash Pratik , Mishra Varun Narayan , Geesupalli Purna Durga , Siddiqui Masood A. , Pandey Prem Chandra , Arabameri Alireza , Arora Aman 
Published: June 2023

AbstractThis study focuses on the mapping of flood susceptibility in a specific region characterized by a low-altitude-range, sub-tropical monsoonal climate, and a riverine floodplain environment within the Middle Ganga Plain. To achieve this, four novel artificial intelligence model ensembles were employed. The aim was to compare the performance of these models in a distinct, tectonically active topoclimatic fluvial floodplain setting and determine the significance of different causative variables. The information obtained from this analysis can be highly valuable for planning and policymaking related to flood management principles. The entire Ganga Foreland Basin, which includes the Middle Ganga Plain, experiences frequent floods of varying magnitudes, underscoring the importance of this modeling exercise. To conduct this study, a comprehensive flood inventory and twelve selected flood conditioning factors were utilized in the development, testing (using 30% of the data), and validation (using another 30% of the data) of the four novel artificial intelligence models: LR-EBF, LR-FR, MLP-EBF, and MLP-FR. These models have been explored less in existing literature. The results revealed that the LR-based ensembles (LR-FR, LR-EBF: SRLR−FR= 86.7%, PRLR−FR= 83.9%, SRLR−EBF= 87.2%, PRLR−EBF= 84.7%) outperformed the MLP-based ensembles (MLP-FR, MLP-EBF: SRMLP−FR= 85.8%, PRMLP−FR= 82.8%, SRMLP−EBF= 86.4%, PRMLP−EBF= 84.4%) in the selected topoclimatic setting of the present study. Additionally, the LR-based ensemble with EBF demonstrated superior performance compared to the MLP-based ensemble with EBF. One notable finding of this study is the variation in performance among the four ensembles when applied in different topoclimatic and altitudinal range environments. The study revealed that the performance differences between LR-based ensembles employing both FR and EBF statistical models were consistent across all environments, exhibiting similar accuracy (in terms of AUROC) with less than a 5% disparity in success and prediction rates. This suggests that these models are likely to perform similarly across various environments. However, the performance differences in MLP-based ensembles, particularly with FR, were more significant, reaching up to a 10% disparity. Therefore, it is recommended to apply these models in high altitudinal range terrains with different topoclimatic settings to those considered in the present study. Notably, even the MLP-based ensemble with EBF displayed relatively consistent performance in varying topoclimatic and altitudinal range environments.
Prussian Blue Modified Magnetite Decorated MW-CNT Nanocomposite: Synthesis, Characterization and Potential Use as Photo-Fenton Catalysts for Phenol Degradation
Authors: Gögen Yusuf , Koçak Çağrı Ceylan , Karabiberoğlu Şükriye , Polatdemir Elmas , Aslaner Harun , Zorlu Rabia , Çağlar Bülent , Çirak Çağrı , Özdokur Kemal Volkan 
Published: June 2023

Abstract
Removal of organic pollutants with green and efficient methods is an important goal for researchers studying environmental pollution. Photo-Fenton systems with heterogeneous catalysts are a promising alternative for efficient water treatment. In this study, Prussian blue modified magnetite decorated multi-walled carbon nanotubes (MW-CNT) nanocomposite was prepared and for the first time applied to the photo-Fenton degradation of phenol. The catalyst was prepared by rapid hydrothermal method. XPS, SEM-EDX, XRD, FTIR methods were used for characterizing the functionalities and morphology of the catalyst. The effect of initial H2O2 concentration, catalyst mass, and initial pH of the phenol solution was investigated. Experimental results showed that 100 mg dm-3 of phenol could be degraded completely in 15 minutes at pH 7. This study describes the synthesis of the new Photo-Fenton catalyst for highly effective phenol treatment.