bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shaking table tests of a full‐scale 10‐story reinforced‐concrete building (2015). Phase II: Seismic resisting system
Authors: Kang Jae‐Do , Kajiwara Koichi , Tosauchi Yusuke , Sato Eiji , Inoue Takahito , Kabeyasawa Toshimi , Shiohara Hitoshi , Nagae Takuya , Kabeyasawa Toshikazu , Fukuyama Hiroshi , Mukai Tomohisa 
Published: February 2023

AbstractA 10‐story reinforced‐concrete (RC) building was subjected to a shaking table test using E‐Defense, the largest three‐dimensional earthquake simulator in the world, to estimate the effects of a flexible foundation and seismic response of a mid‐rise building. Two structural systems with different base supporting conditions were adopted for two phases of tests for comparative purposes: the first system was free‐standing with base sliding and uplifting, and the second was a conventional RC seismic resisting system with a fixed base. This paper mainly reports the test results for the conventional RC seismic resisting system with a fixed base, which comprises a moment‐resisting frame system in the longitudinal direction and a frame system with multistory shear walls in the transverse direction. The objective of this research was to confirm the seismic capacity of a mid‐rise building designed in accordance with current Japanese building standards and guidelines. Even though the story drift ratio exceeded 3% under extreme motion exceeding the design earthquake, the structure remained stable throughout the tests, satisfying the design concept of collapse prevention performance, whereas relatively severe damage was observed in the beam–column joints. Crack observations indicated massive damage sustained by the beam–column joints. The measured shear deformations at the beam–column joints accounted for more than half of the inter‐story drift at the peak response.
AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male-Biased Sex Ratio and Population Decline in Fish
Authors: Ankley Gerald T. , Santana-Rodriguez Kelvin , Jensen Kathleen M. , Miller David H. , Villeneuve Daniel L. 
Published: February 2023

Abstract
Screening and testing of potential endocrine-disrupting chemicals for ecological effects are examples of risk assessment/regulatory activities that can employ adverse outcome pathways (AOPs) to establish linkages between readily measured alterations in endocrine function and whole organism– and population-level responses. Of particular concern are processes controlled by the hypothalamic–pituitary–gonadal/thyroidal (HPG/T) axes. However, the availability of AOPs suitable to meet this need is currently limited in terms of species and life-stage representation relative to the diversity of endpoints influenced by HPG/T function. In our report we describe two novel AOPs that comprise a simple AOP network focused on the effects of chemicals on sex differentiation during early development in fish. The first AOP (346) documents events starting with inhibition of cytochrome P450 aromatase (CYP19), resulting in decreased availability of 17β-estradiol during gonad differentiation, which increases the occurrence of testis formation, resulting in a male-biased sex ratio and consequent population-level declines. The second AOP (376) is initiated by activation of the androgen receptor (AR), also during sexual differentiation, again resulting in a male-biased sex ratio and population-level effects. Both AOPs are strongly supported by existing physiological and toxicological evidence, including numerous fish studies with model CYP19 inhibitors and AR agonists. Accordingly, AOPs 346 and 376 provide a basis for more focused screening and testing of chemicals with the potential to affect HPG function in fish during early development. Environ Toxicol Chem 2023;42:747–756. Published 2023. This article is a U.S. Government work and is in the public domain in the USA.
Detrital zircon U–Pb isotopes and whole‐rock geochemistry of early Palaeozoic sediments of the Baoshan and Lancang Blocks, SW China: Implications for Proto‐Tethys evolution and Gondwana reconstruction
Authors: Gao Yu , Li Gang , Liu Zhenghong , Liu Junlai , Wang Chen , Xu Zhongyuan , Wang Changbing 
Published: February 2023

The palaeogeographic reconstruction of the microcontinents on the northern margin of Gondwanaland and the tectonic evolution model of the Proto‐Tethys in the Early Palaeozoic remain controversial. The Baoshan and Lancang Blocks in SW Yunnan, China, were located on the northern margin of the Gondwana continent during the Early Palaeozoic. In this study, we present new zircon U–Pb ages and whole‐rock geochemistry data for the sedimentary rocks of the Lancang Group in the Lancang Block and the Mengtong Group in the Baoshan Block to reveal the nature of sedimentary provenance with a further tectonic evolution model of the Proto‐Tethys. Our new detrital zircon U–Pb results, in conjunction with the published age of the metamorphic volcanic rock interlayers, suggest that the Mengtong and Lancang groups were probably deposited during the Early Palaeozoic. The Mengtong and Lancang groups have similar detrital zircon age spectra and display three distinctive age peaks at 1.2–1.1 Ga, ~0.95 Ga, and 0.6–0.5 Ga. This implies that the Baoshan‐Lancang Block was situated in the transitional zone between India and Australia on the Gondwana margin and received detritus from both cratons. Combined with abundant volcanic rocks in the Lancang Group and SSZ‐type ophiolites in the Changning‐Menglian belt, the Lancang Block should be reconstructed as a continental island arc of the Baoshan Block in the Early Palaeozoic. The geochemical analysis results show that the sediments of the two strata were primarily sourced from felsic rocks in the upper crust, and they were deposited in the active continental margin. Combined with previous research, we propose a new tectonic evolution model for the Proto‐Tethys Ocean in the Early Palaeozoic, from bisubduction to collisional orogeny.
Contextual fear conditioning with a time interval induces CREB phosphorylation in the dorsal hippocampus and amygdala nuclei that depend on prelimbic cortex activity
Authors: Santos Thays Brenner , Kramer‐Soares Juliana Carlota , Oliveira Maria Gabriela Menezes 
Published: February 2023

AbstractIn temporal associations, a conditioned stimulus (CS) is separated by a time interval from the unconditioned stimulus (US), which activates the prelimbic cortex (PL) to maintain a CS representation over time. However, it is unknown whether the PL participates, besides the encoding, in the memory consolidation, and thus directly, with activity‐dependent changes or indirectly, by modulation of activity‐dependent changes in other brain regions. We investigated brain regions supporting the consolidation of associations with intervals and the influence of PL activity in this consolidation process. For this, we observed in Wistar rats the effect of pre‐training PL inactivation by muscimol in CREB (cAMP response element‐binding protein) phosphorylation, which is essential for memory consolidation, in subdivisions of the medial prefrontal cortex (mPFC), hippocampus, and amygdala 3 h after the training in the contextual fear conditioning (CFC) or CFC with 5‐s interval (CFC‐5s), fear associations without or with an interval between the CS and US, respectively. Both the CFC‐5s and CFC training increased phosphorylation of CREB in the PL and infralimbic cortex (IL); lateral (LA) and basolateral (BLA) amygdala; dorsal CA1 (dCA1); dorsal (dDG), and ventral dentate gyrus, and the CFC‐5s training in the central amygdala (CEA). PL activity was necessary for the CREB phosphorylation in the PL, BLA, CEA, dCA1, and dDG only in animals trained in the CFC‐5s. The cingulate cortex, ventral CA1, and ventral subiculum did not have learning‐induced phosphorylation of CREB. These results suggest that the mPFC, hippocampus, and amygdala support the consolidation of associations with or without intervals and that PL activity influences consolidation in the dorsal hippocampus and amygdala in temporal associations. Thereby, the PL contributes directly and indirectly by modulation to memory consolidation. The time interval engaged the PL early in recent memory consolidation. Results expanded PL's role beyond the time interval and remote memory consolidation.
AI tools such as ChatGPT will disrupt hydrology, too
Authors: Halloran Landon J. S. , Mhanna Saeed , Brunner Philip 
Published: February 2023

AbstractSince its public release in late 2022, the artificial intelligence (AI) tool ChatGPT has generated considerable excitement and consternation. Many scientists, including hydrologists, view this tool and others like it as threats, while others dismiss them as irrelevant distractions. Although the capability of this technology to ‘do’ hydrological research is lacking, AI tools like ChatGPT present significant opportunities—with caveats—for the hydrology community and deserve close inspection by all.
Adjuvant treatment of in‐transit melanoma: Narrowing the knowledge gap left by clinical trials
Authors: de Meza Melissa M. , Blokx Willeke A. M. , Bonenkamp Han J. , Blank Cristian U. , Aarts Maureen J. B. , van den Berkmortel Franchette W. P. J. , Boers‐Sonderen Marye J. , de Groot Jan Willem B. , Haanen John B. , Hospers Geke A. P. , Kapiteijn Ellen W. , van Not Olivier J. , Piersma Djura , van Rijn Rozemarijn S. , Stevense‐Den Boer Marion A. , van der Veldt Astrid A. M. , Vreugdenhil Gerard , van den Eertwegh Alfons J. M. , Suijkerbuijk Karijn P. M. , Wouters Michel W. J. M. 
Published: February 2023

AbstractFew clinical trials address efficacy of adjuvant systemic treatment in patients with in‐transit melanoma (ITM). This study describes adjuvant systemic therapy of ITM patients beyond clinical trials. In this study, we included stage III adjuvant‐treated melanoma patients registered in the nationwide Dutch Melanoma Treatment Registry between July 2018 and December 2020. Patients were divided into three groups: nodal disease only, ITM only and ITM and nodal disease. Recurrence patterns, recurrence‐free survival (RFS) and overall survival (OS) at 12‐months were analyzed. In our study population of 1037 patients, 66.8% had nodal disease only, 16.7% had ITM only and 16.2% had ITM with nodal disease. RFS at 12‐months was comparable in the nodal only and ITM only group (72.2% vs70.1%,P = .97) but lower in ITM and nodal disease patients (57.8%;P = .01,P < .01). Locoregional metastases occurred as first recurrence in 38.9% nodal disease only, 71.9% of ITM‐only and 44.0% of ITM and nodal disease patients. Distant recurrences occurred in 42.3%, 18.8% and 36.0%, respectively (P = .02). 12‐months OS was not significantly different for nodal disease only patients compared with ITM‐only (94.4% vs 97.6%,P = .06) but was significantly higher for ITM‐only compared with ITM and nodal disease patients (97.6% vs 91.0%,P < .01). In conclusion, we showed that in the adjuvant setting, RFS rates in ITM‐only patients are similar to non‐ITM, though better than in ITM and nodal disease patients. Adjuvant‐treated ITM‐only patients less often experience distant recurrences and have a superior OS compared with ITM and nodal disease patients.
The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer
Authors: Alavi Negin , Maghami Parvaneh , Fani Pakdel Azar , Rezaei Majid , Avan Amir 
Published: February 2023

AbstractWe evaluated the activity of core‐shell ZnO nanoparticles (ZnO‐NPs@polymer shell) containing Oxaliplatin via polymerization through in vitro studies and in vivo mouse models of colorectal cancer. ZnO NPs were synthesized in situ when the polymerization step was completed by co‐precipitation. Gadolinium coordinated‐ZnONPs@polymer shell (ZnO‐Gd NPs@polymer shell) was synthesized by exploiting Gd's oxophilicity (III). The biophysical properties of the NPs were studied using powder X‐ray diffraction (PXRD), Fourier transforms infrared spectroscopy, Ultraviolet‐visible spectroscopy (UV‐Vis), field emission electron microscopy (FESEM), transmission electron microscopy (TEM), atomic force microscopy, dynamic light scattering, and z‐potential. (3‐(4,5‐Dimethylthiazol‐2‐yl)−2,5‐diphenyltetrazolium bromide) (MTT) was used to determine the antiproliferative activity of ZnO‐Gd‐OXA. Moreover, a xenograft mouse model of colon cancer was exerted to survey its antitumor activity and effect on tumor growth. In the following, the model was also evaluated by histological staining (H‐E; Hematoxylin & Eosin and trichrome staining) and gene expression analyses through the application of RT‐PCR/ELISA, which included biochemical evaluation (MDA, thiols, SOD, CAT). The formation of ZnO NPs, which contained a crystallite size of 16.8 nm, was confirmed by the outcomes of the PXRD analysis. The Plate‐like morphology and presence of Pt were obtained in EDX outcomes. TEM analysis displayed the attained ZnO NPs in a spherical shape and a diameter of 33 ± 8.5 nm, while the hydrodynamic sizes indicated that the particles were highly aggregated. The biological results demonstrated that ZnO‐Gd‐OXA inhibited tumor growth by inducing reactive oxygen species and inhibiting fibrosis, warranting further research on this novel colorectal cancer treatment agent.
Alum reduced phosphorus release from flooded soils under cold spring weather conditions
Authors: Lasisi Ahmed , Weerasekara Chamara S. , Kumaragamage Darshani , Akinremi Olalekan O. 
Published: February 2023

AbstractThe effectiveness of amendments such as alum [Al2(SO4)3·18H2O] in reducing phosphorus (P) loss to floodwater has been reported under summer conditions and laboratory‐controlled environments, but not under actual spring weather conditions in cold climate regions with high diurnal temperature variations when potential for P losses is high. The effectiveness of alum in reducing P release under Manitoba spring weather conditions was evaluated in a 42‐day experiment using 15‐cm soil monoliths from eight agricultural soils, which were unamended or alum‐amended (5 Mg ha−1) and flooded to a 10‐cm head. Dissolved reactive P (DRP) concentrations and pH of porewater and floodwater were determined on flooding day and every 7 days after flooding (DAF). Porewater and floodwater DRP concentrations in unamended soils increased 1.4‐ to 4.5‐fold, and 1.8‐ to 15.3‐fold, respectively, from 7 to 42 DAF. In alum‐amended soils, DRP concentrations averaged across soils was 43%–73% (1.0–2.0 mg L−1) lower in porewater, and 27%–64% (0.1–1.2 mg L−1) lower in floodwater than unamended soils during the flooding period. The reduction of DRP by alum was more pronounced under high fluctuating diurnal spring air temperature than with controlled air temperature (4°C) in a previous similar study. Acidic pH in porewater and floodwater due to alum did not persist over 7 days. This study showed that alum application is a viable option in reducing P released to floodwater in agricultural soils of cold regions where flooding‐induced P loss is prevalent in the spring.
Effects of atmospheric and manure surface conditions on H2S emissions from an in‐ground finisher hog manure slurry tank
Authors: Grant Richard H. , Boehm Matthew T. 
Published: February 2023

AbstractHydrogen sulfide (H2S) emitted by livestock operations can be detrimental to human health. The storage of hog manure is a significant agricultural source of H2S emissions. H2S emissions from a ground‐level Midwestern hog finisher manure tank were measured for 8–20 days each quarter over a 15‐month period. After excluding 4 days with outlier emissions the mean daily emission was 1.89 g H2S m−2 day−1. Mean daily emission was 1.39 g H2S m−2 day−1 when the slurry surface was liquid and 3.00 g H2S m−2 day−1 when crusted. Emissions however were not significantly different whether the surface was liquid or crusted when differences in temperature were considered. Diurnal variation in emissions was not correlated with air temperature, water vapor saturation deficit, or wind speed when the manure surface was crusted but was positively correlated with these variables when the surface was not crusted. Daily H2S emissions were modeled according to two‐film theory incorporating resistance approach with limited success. Additional emissions measurements with greater documentation of the manure liquid composition and crust characteristics are needed to assess the component transport resistances in the emissions model.
Clinical efficacy and safety of molnupiravir for nonhospitalized and hospitalized patients with COVID‐19: A systematic review and meta‐analysis of randomized control trials
Authors: Huang Po‐Yu , Liu Ting‐Hui , Wu Jheng‐Yan , Tsai Ya‐Wen , Lai Chih‐Cheng 
Published: February 2023

AbstractThe efficacy of molnupiravir in treating patients with coronavirus disease 2019 (COVID‐19) has been inconsistent across randomized controlled trials (RCTs). Thus, this meta‐analysis was conducted to clarify the literature. A literature search of electronic databases—PubMed, Embase, and Cochrane Library—was performed to identify relevant articles published up to December 31, 2022. Only RCTs that investigated the clinical efficacy and safety of molnupiravir for patients with COVID‐19 were included. The primary outcome was all‐cause mortality at 28–30 days. This pooled analysis of nine RCTs did not reveal a significant difference in all‐cause mortality between molnupiravir and control groups (risk ratio [RR], 0.43; 95% confidence interval [CI], 0.10–1.77) for overall patients. However, the risks of mortality and hospitalization were lower in the molnupiravir group than in the control group (mortality: RR, 0.28; 95% CI, 0.10–0.79; hospitalization: RR, 0.67; 95% CI, 0.45–0.99) among nonhospitalized patients. In addition, molnupiravir use was associated with a borderline higher virological eradication rate relative to the control (RR, 1.05; 95% CI, 1.00–1.11). Finally, no significant difference in adverse event risk was discovered between the groups (RR, 0.98; 95% CI, 0.89–1.08). The findings reveal the clinical benefits of molnupiravir for nonhospitalized patients with COVID‐19. However, molnupiravir may not improve the clinical outcomes of hospitalized patients. These findings support the recommended use of molnupiravir for treating nonhospitalized patients with COVID‐19 but not for hospitalized patients.
Ultrahigh Power Density LuAG:Ce Green Converters For High‐Luminance Laser‐Driven Solid State Lighting
Authors: Wen Qianxiong , Wang Yu , Zhao Cong , Xu Li , Wang Xidong , Xu Yusai , Lin Sai , Liang Xiaojuan , Liu Jianping , Xiang Weidong 
Published: February 2023

AbstractLu3Al5O12:Ce (LuAG:Ce) phosphor has been designed and fabricated into various forms of green fluorescent converters and plays a critical role in the field of solid‐state laser lighting. Phosphor in glass (PiG) and phosphor in glass film (PiGF) are expected to be viable strategies for high‐power and high‐brightness laser diode (LD) illumination due to their easy synthesis and low cost. In this study, LuAG:Ce‐PiG with an internal quantum efficiency of 90.5% is prepared by investigating the sintering conditions and combining with a borosilicate glass. It possesses a luminous flux (LF) of 584 lm and luminous efficiency (LE) of 225 lm W−1 @ 20 W mm−2. On this basis, LuAG:Ce‐PiG sapphire film (LuAG:Ce‐PiGSF) with high thermal conduction (10.26 W (m K) −1) is successfully sintered on the sapphire to obtain the LF of 833 lm and LE of 252 lm W−1 @ 36.36 W mm−2. The maximum tolerated power density can reach 45.45 W mm−2. In addition, when the color converters are placed in a commercial LD transmission module and continuously light for 24 h at 16.5 W, the relative light intensity only decreases by 14.15% and 12.82%, respectively. Therefore, it is believed that the work has promising applications in laser illumination and accelerating the development of LD lighting.
Pricey therefore good? Price affects expectations, but not quality perceptions and liking
Authors: Kurz Jacqueline , Efendić Emir , Goukens Caroline 
Published: February 2023

AbstractPrice and quality are positively related in people's minds. Saying a product costs more ought to lead to higher expectations of quality and liking. Importantly, this price‐quality heuristic is argued to affect perceived quality and liking—known as the marketing placebo effect. To investigate the robustness of this effect, we conducted six studies (total N = 2842; with students from an international Dutch university and US participants from Prolific and MTurk)—expanding on previous methodological approaches with larger samples and using products not commonly investigated in previous research. In all our studies, higher prices led to higher quality and liking expectations as suggested by the price‐quality heuristic. However, we did not find a consistent effect on perceived quality and liking once people experienced the product. Our data imply that the marketing placebo effect may be less robust or generalizable as previously assumed. This (in)efficacy should bring marketers to pause on when and whether to rely on it at all.
Human microbiomes in cancer development and therapy
Authors: Xia Chenglai , Su Jiyan , Liu Can , Mai Zhikai , Yin Shuanghong , Yang Chuansheng , Fu Liwu 
Published: February 2023

AbstractColonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their microbial species, and their metabolites are different; the mechanisms of carcinogenic or procancerous are also different. Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy. We also insight into the molecular mechanisms of triggering, promoting, or inhibiting carcinogenesis and disease progress induced by microbiomes or/and their secretions of bioactive metabolites. And then, the strategies of application of microorganisms in cancer treatment were discussed in detail. However, the mechanisms by which human microbiomes function are still poorly understood. The bidirectional interactions between microbiotas and endocrine systems need to be clarified. Probiotics and prebiotics are believed to benefit human health via a variety of mechanisms, in particular, in tumor inhibition. It is largely unknown how microbial agents cause cancer or how cancer progresses. We expect this review may open new perspectives on possible therapeutic approaches of patients with cancer.