bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recruiting African American Prostate Cancer Survivors for a Population-based Biobank Study
Authors: Li Xiaoyin , Roy Siddhartha , Damonte Jennifer , Park Hyun Y. , Hoogland Aasha I. , Jamison Kala , Komrokji Khaled R. , Yeo Chang Dong , Kim Youngchul , Dhillon Jasreman , Gudenkauf Lisa M. , Oswald Laura B. , Jim Heather S.L. , Yamoah Kosj , Pow-Sang Julio M. , Kanetsky Peter A. , Gwede Clement K. , Park Jong Y. , Gonzalez Brian D. 
Published: March 2023

Abstract

Background:
Prostate cancer affects African American men disproportionately compared with men of other racial/ethnic groups. To identify biological bases for this health disparity, we sought to create a state-wide biobank of African American prostate cancer survivors in Florida.

Methods:
African American men diagnosed with prostate cancer between 2013 and 2017 and living in Florida at diagnosis were identified through the State of Florida's cancer registry. Individuals were approached via mail and telephone, assessed for eligibility, and asked for informed consent. χ2 and t tests were conducted to identify differences between eligible and reachable individuals (i.e., had valid contact information) versus consented participants.

Results:
Of the 5,960 eligible and reachable individuals, 3,904 were eligible and contacted at least once, and 578 consented [overall consent rate = 10% (578/5,960); adjusted consent rate = 15% (578/3,904)]. Statistically significant (Ps &lt; 0.05) but small differences in demographic and clinical variables were observed. Consented participants were less likely to be older than 64 (35% vs. 41%) and less likely to have received radiotherapy (36% vs. 41%) and hormone therapy (16% vs. 21%), but more likely to have regional prostate cancer (13% vs. 11%) and have undergone surgery (44% vs. 39%). Consented participants did not differ from reachable individuals on other demographic and clinical factors (Ps &gt; 0.05).

Conclusions:
Recruiting African American prostate cancer survivors to biobanking research through a cancer registry is feasible. However, the consent rate was low, and existing challenges limit consent and participation.

Impact:
Strategies for overcoming barriers to informed consent and increasing participation in biospecimen research are needed to address cancer disparities.
Efficacy of the Outsmart HPV Intervention: A Randomized Controlled Trial to Increase HPV Vaccination among Young Gay, Bisexual, and Other Men Who Have Sex with Men
Authors: Reiter Paul L. , Gower Amy L. , Kiss Dale E. , Shoben Abigail B. , Katz Mira L. , Bauermeister José A. , Paskett Electra D. , McRee Annie-Laurie 
Published: March 2023

Abstract

Background:
Routine human papillomavirus (HPV) vaccination is recommended for young adults, yet many young gay, bisexual, and other men who have sex with men (YGBMSM) remain unvaccinated. We report the efficacy of Outsmart HPV, a web-based HPV vaccination intervention for YGBMSM.

Methods:
From 2019 to 2021, we recruited YGBMSM in the United States who were ages 18–25 and unvaccinated against HPV (n = 1,227). Participants were randomized to receive either: (i) Outsmart HPV content online and monthly interactive text reminders (interactive group); (ii) Outsmart HPV content online and monthly unidirectional text reminders (unidirectional group); or (iii) standard information online about HPV vaccine (control group). Regression models compared study groups on HPV vaccination outcomes.

Results:
Overall, 33% of participants reported initiating the HPV vaccine series and 7% reported series completion. Initiation was more common among participants in the interactive group compared with the control group [odds ratio (OR) = 1.47, 98.3% confidence interval (CI): 1.03–2.11]. Completion was more common among participants in both the interactive group (OR = 3.70, 98.3% CI: 1.75–7.83) and unidirectional group (OR = 2.26, 98.3% CI: 1.02–5.00) compared with the control group. Participants who received Outsmart HPV content reported higher levels of satisfaction with online content compared with the control group.

Conclusions:
Outsmart HPV is an efficacious and acceptable HPV vaccination intervention for YGBMSM. Future efforts are needed to determine how to optimize the intervention and disseminate it to settings that provide services to YGBMSM.

Impact:
Outsmart HPV is a promising tool for increasing HPV vaccination among YGBMSM with the potential for wide dissemination.
Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT Axis
Authors: Liao Xinyi , Li Ziwen , Zheng Haiqing , Qian Wanying , Zhang Shuxia , Chen Suwen , Li Xincheng , Tang Miaoling , Xu Yingru , Yu Ruyuan , Li Man , Song Libing , Li Jun 
Published: March 2023

Abstract

The chemoresistance of temozolomide-based therapy is a serious limitation for lasting effective treatment of gliomas, while the underlying mechanisms remain unclear. In this study, we showed that downregulation of BASP1 correlated negatively with the response to temozolomide therapy and disease-free survival (DFS) of patients with gliomas. Silencing BASP1 significantly enhanced the temozolomide resistance of glioma cells both in vitro and in vivo through repair of temozolomide-induced DNA damage via activation of the FBXO32/NF-κB/MGMT axis in both MGMT-methylated and -unmethylated gliomas. We demonstrated that loss of BASP1 resulted in removal of TRIM37/EZH2 complex–induced repressive histone modifications, including H2A-ub and H3K27me3, but addition of WDR5/MLL complex–mediated active histone modifications, including H3K4me3 and H3K9ac, on the FBXO32 promoter, which elicited in FBXO32 upregulation and further activated NF-κB/MGMT signaling via ubiquitin-dependent degradation of IκBα. Importantly, treatment with OICR-9429, an antagonist of the WDR5–MLL interaction, impaired the FBXO32/NF-κB/MGMT axis–mediated repair of temozolomide-induced DNA damage, leading to significant apoptosis of BASP1-downregulated glioma cells. These findings shed light on the molecular mechanism underlying BASP1-mediated epigenetic transcriptional repression and may represent a potential strategy in the fight against temozolomide-resistant gliomas.

Implications:
BASP1 downregulation promotes temozolomide resistance in gliomas through WDR5/MLL complex–mediated epigenetic activation of the FBXO32/NF-κB/MGMT axis, providing new target for improving outcomes in patients with temozolomide-resistant gliomas.
Making the (Letter) Grade: The Incentive Effects of Mandatory Pass/Fail Courses
Authors: Butcher Kristin , McEwan Patrick J. , Weerapana Akila 
Published: March 2023

Abstract
In fall 2014, Wellesley College began mandating pass/fail grading for courses taken by first-year, first-semester students, although instructors continued to record letter grades. We identify the causal effect of the policy on course choice and performance, using a regression-discontinuity-in-time design. Students shifted to lower-grading science, technology, engineering, and mathematics (STEM) courses in the first semester, but did not increase their engagement with STEM in later semesters. Letter grades of first-semester students declined by 0.13 grade points, or 23 percent of a standard deviation. We evaluate causal channels of the grade effect—including sorting into lower-grading STEM courses and declining instructional quality—and conclude that the effect is consistent with declining student effort.
“And All of That”: The Long List in Political Discourse
Authors: Reijven Menno H. , Durrani Alina , Dori-Hacohen Gonen 
Published: March 2023

Abstract
We look at long lists (i.e., longer than three parts) in political discourse, especially in talk shows from three cultures, the U.S., Pakistan, and the Netherlands, and ask how a long list is accomplished. Long lists are routinely produced in political discourse by extending the typical three-part list. The listing process to create a long list can happen in many ways, explicitly via counting verbally or physically and implicitly through other resources. These resources can also be used to project a list in advance and to create one retrospectively. Last, listing in politics creates two problems for the lister, requiring an artful application of the available listing resources. The audience may orient to only three parts, and the politician is faced with selecting the last item. Thus, we show that politicians use lists to structure their talk, but they also have to anticipate problems regarding the practice of listing.
Subsurface Eddy Detection Optimized with Potential Vorticity from Models in the Arabian Sea
Authors: Ernst Paul A. , Subrahmanyam Bulusu , Morel Yves , Trott Corinne B. , Chaigneau Alexis 
Published: March 2023

Abstract
Coherent ocean vortices, or eddies, are usually tracked on the surface of the ocean. However, tracking subsurface eddies is important for a complete understanding of deep ocean circulation. In this study, we develop an algorithm designed for the detection of subsurface eddies in the Arabian Sea using Nucleus for European Modelling of the Ocean (NEMO) model simulations. We optimize each parameter of our algorithm to achieve favorable results when compared with an algorithm using sea surface height (SSH). When compared to similar methods, we find that using the rescaled isopycnal potential vorticity (PV) is best for subsurface eddy detection. We proceed to demonstrate that our new algorithm can detect eddies successfully between specific isopycnals, such as those that define the Red Sea Water (RSW). In doing so, we showcase how our method can be used to describe the properties of eddies within the RSW and even identify specific long-lived subsurface eddies. We conduct one such case study by discerning the structure of a completely subsurface RSW eddy near the Chagos Archipelago using Lagrangian particle tracking and PV diagnostics. We conclude that our rescaled PV method is an efficient tool for investigating eddy dynamics within the ocean’s interior, and publicly provide our optimization methodology as a way for other researchers to develop their own subsurface detection algorithms with optimized parameters for any spatiotemporal model domain.

Significance Statement
Eddies are a key part of ocean circulation both at the surface and in the subsurface. The purpose of our study was to design the first detection method comprehensively optimized for subsurface eddy detection from numerical simulations. We demonstrate that potential vorticity (PV) is the best field to use when algorithmically tracking eddies in subsurface water masses, using our new method to identify and track eddies in the Red Sea Water (RSW). Additionally, our method allows us to efficiently evaluate the dynamics of eddies through potential vorticity diagnostics, exemplified with a previously undescribed eddy near the Chagos Archipelago. Our methodology can be used by future researchers to study the eddy dynamics hidden within subsurface water masses around the world.
Flourishing During the COVID-19 Pandemic: A Longitudinal Study in South Africa
Authors: Wilson Fadiji A. , de la Rosa P. A. , Counted V. , De Kock J. H. , Bronkhorst W. L. R. , Joynt S. , Tesfai A. , Nyamaruze P. , Govender K. , Cowden R. G. 
Published: March 2023

In this longitudinal study, we examine changes in psychological distress and multidimensional well-being from before to during the COVID-19 pandemic among South African adults. As a secondary purpose, we explore whether pre-pandemic flourishing is protective against subsequent psychological distress during the public health crisis. The analytic sample ( n = 293; Mage = 44.27, SD = 14.28; female = 65.19%) completed measures of anxiety symptoms, depression symptoms, and well-being shortly before the stringent nationwide lockdown started in South Africa (T1). A follow-up assessment was completed approximately 6 months later (T2). Paired samples t-tests supported very small improvements in anxiety ( d = −0.09) and depression symptoms ( d = −0.13). For domains of well-being, small increases were found in close social relationships ( d = 0.25) and financial and material stability ( d = 0.19). Positive changes in the domains of character and virtue ( d = 0.10) and meaning and purpose ( d = 0.07) were very small. Changes in physical and mental health ( d = −0.03) and life satisfaction and happiness ( d = 0.02) were more negligible. Results from the generalized linear models indicated that continuous scores of secure flourishing assessed before the COVID-19 pandemic were associated with lower subsequent psychological distress (particularly depression symptoms) during the public health crisis. We discuss the implications of the findings for the development and delivery of interventions to promote and sustain human flourishing during public health crises, especially in contexts of social-structural vulnerability.
Acceptability of Intergenerational Physical Activity Programming: A Mixed Methods Study of Latino Aging Adults in Nebraska
Authors: Ramos Athena K. , Dinkel Danae , Trinidad Natalia , Carvajal-Suarez Marcela , Schmeits Karen , Molina Diana , Boron Julie B. 
Published: March 2023

Objective: This study explored Hispanic/Latino aging adults’ interest in and preferences for intergenerational physical activity programming. Methods: We used an exploratory sequential (Qual-QUAN) mixed methods design consisting of three focus groups ( N = 13 participants; M age = 62.5 years old) and a quantitative survey ( N = 105 participants; M age = 57.3 years old). Results: We found that most participants were interested in intergenerational physical activity programs: (1) to promote overall health and well-being, (2) increase opportunities for socialization and relationships, and (3) foster motivation and energy. Preferences for programming included cultural tailoring, bilingual and Spanish-language offerings, and being conducted in-person. Barriers to physical activity included cost, scheduling, transportation, and limited awareness of community resources. Discussion: Innovative public health initiatives incorporating an intergenerational approach may promote physical activity among aging adults. This study has implications for developing and refining intergenerational programming with Hispanic/Latino communities.
Prognostic Value of En-Block Radical Bowel Resection in Advanced Ovarian Cancer Surgery With HIPEC
Authors: Panoskaltsis T. , Papadimitriou C. , Pallas N. , Karamveri C. , Kyziridis D. , Hristakis C. , Kiriakopoulos V. , Kalakonas A. , Vaikos D. , Tzavara C. , Tentes A. A. 
Published: March 2023

Purpose To identify prognostic factors of survival and recurrence in advanced ovarian cancer patients undergoing radical surgery and HIPEC. Methods In a single Department of Surgical Oncology, Peritoneal Surface Malignancy Program, and over a 16-year period, from a total of 274 epithelial ovarian cancer patients, retrospectively, we identified 152 patients undergoing complete (CC-0) or near-complete (CC-1) cytoreduction, including at least one colonic resection, and HIPEC. Results Mean age of patients was 58.8 years and CC-0 was possible in 72.4%. Rates of in-hospital mortality and major morbidity were 2.6% and 15.7%. Only 122 (80.3%) patients completed Adjuvant Systemic Chemotherapy (ASCH). Rates of metastatic Total Lymph Nodes (TLN), Para-Aortic and Pelvic Lymph Nodes (PAPLN) and Large Bowel Lymph Nodes (LBLN) were 58.7%, 58.5%, and 51.3%, respectively. Median, 5- and 10-year survival rates were 39 months, 43%, and 36.2%, respectively. The recurrence rate was 35.5%. On univariate analysis, CC-1, high Peritoneal Cancer Index (PCI), in-hospital morbidity, and no adjuvant chemotherapy were adverse factors for survival and recurrence. On multivariate analysis, negative survival indicators were the advanced age of patients, extensive peritoneal dissemination, low total number of TLN and no systemic PAPLN. Metastatic LBLN and segmental resection of the small bowel (SIR) were associated with a high risk for recurrence. Conclusion CC-O is feasible in most advanced ovarian cancer patients and HIPEC may confer a survival benefit. Radical bowel resection, with its entire mesocolon, may be necessary, as its lymph nodes often harbor metastases influencing disease recurrence and survival. The role of metastatic bowel lymph nodes has to be taken into account when assessing the impact of systemic lymphadenectomy in this group of patients.
Living in a segregated community? Interaction between families and service organizations supporting people with intellectual disabilities during the COVID-19 pandemic
Authors: Shum Michelle Hei Yan , Kwan Chi Kin , Yeung Maggie Pin Mui , Fung Kwok Kin , Ching Joshua Chi Lam 
Published: March 2023

Summary Individuals with intellectual disabilities who might have been previously placed into segregated institutions now live independently in the community, supported by the necessary community care services. Nevertheless, social inclusion can be deemed successful only if they can positively interact with the various microsystems of the community. The disruption of social service provision due to the COVID-19 pandemic allowed us to evaluate other systems of support in the community. By adopting a bioecological perspective, qualitative methods are used to examine the interactions between people with intellectual disabilities and their social environment during the pandemic primarily based on focus group sessions with 17 social workers and 12 caregivers. Findings Three overarching themes are identified through a thematic analysis: (1) limited social ties with the community that could provide support; (2) professional support as the main source of assistance; and (3) limited resources on how to care for people with intellectual disabilities. Applications The results show that unilateral systems of support with limited participation of other systems lead people with intellectual disabilities to live segregated lives, even though they reside in the community. To fully realize the right of inclusion in society of all people with intellectual disabilities, further efforts are required to promote informal social care for people with intellectual disabilities. There is a need for a shared-care model that provides care in the community by the community through the establishment of neighborly relations and expansion of the social networks of people with intellectual disabilities.
Comprehensive Learning Curve Analysis of a Long-Term Experience With Thoracic Endovascular Aneurysm Repair
Authors: Gennai Stefano , Leone Nicola , Bartolotti Luigi AM , Andreoli Francesco , Migliari Mattia , Silingardi Roberto 
Published: March 2023

Purpose: To analyze the learning curve for thoracic endovascular aortic repair (TEVAR) in a single center over a period of 25 years. Materials and Methods: In total, 390 consecutive standard TEVAR procedures undertaken between 1996 and 2021 were included in a retrospective, observational, single-center study. Cumulative sum charts were elaborated for the entire center experience (primary outcome) as well as for the first and second implanting physicians. Data on procedural variables (contrast volume, operative and fluoroscopy time), 30-day major adverse events (MAEs) and clinical success, and endoleak and reintervention rates were secondary outcomes and subdivided into 4 quartiles of experience (Q1–Q4) or presented as first 2 versus latest 2 quartiles (Q1–Q2 vs Q3–Q4). Results: The mean follow-up was 4.3±4.0 years. The center’s learning curve was achieved after 75 procedures, and it was similar for the first implanting physician. The surgeon coming thereafter had a significantly shorter curve (10 TEVARs). Comparing Q1–Q2 with Q3–Q4, 30-day MAEs (16.1 vs 11.3%, p=0.164), 30-day mortality (11.4% vs 3.6%, p=0.003), and intraoperative additional maneuvers (21.5% vs 13.3%, p=0.033) were reduced along with an improvement in clinical success (85.9% vs 90.3%, p=0.190). From Q1 to Q4, operative time (139.8±65.5 to 76.7±43.7 min, p=0.001), fluoroscopy time (15.1±8.8 to 7.1±5.1 min, p<0.001), and contrast volume (244.0±112.1 to 104.3±46.1 mL, p<0.001) showed a considerable reduction. Late endoleak and aortic-related mortality declined significantly from Q1–Q2 to Q3–Q4 (24.1% to 15.5%, p=0.033 and 18.6% vs 8.2%, p=0.006, respectively). Operative time (p=0.021), contrast volume (p=0.016), and fluoroscopy time (p=0.004) were independent risk factors for endoleak, causing a 1.3-fold risk increase for both each 60 minutes of additional operative time (p=0.021) and every 100 mL of additional contrast medium (p=0.016). Each 10-minute increase in fluoroscopy time determined a 1.4-fold risk increment (p=0.004). Conclusion: The learning curve shortened significantly over time with non-negligible clinical outcome improvements, suggesting that specific endovascular training is mandatory to become an effective TEVAR performer. Clinical Impact For the first time in literature, the standard TEVAR’s learning curve has been evaluated at a single vascular surgery center over a period of 25 years. The learning curve for the center and the first physician historically undertaking TEVAR was achieved at the 75th treated patient. The learning curve of the surgeons coming thereafter was significantly shorter (10 cases). This quarter-century demonstrated that intraoperative learning-related variables were associated with long-term clinical outcomes and all have improved over time. Centers approaching TEVAR for the first time and training program providers could use these data to aim to offer better clinical outcomes.
Re-Rupture 2 Years after Endovascular Aortic Aneurysm Repair Rupture
Authors: Moulakakis Konstantinos G , Tsimpoukis Andreas , Katsanos Konstantinos , Sintou Eleni , Papadoulas Spyros 
Published: March 2023

Re-rupture 2 years after endovascular aortic aneurysm repair (EVAR) rupture is an extremely rare event and limited data exist in the literature. We present an interesting case of a patient with an abdominal aortic rupture that had undergone 2 years before an endovascular repair for rupture after EVAR due to a type IA endoleak. The patient underwent a successful embolization of the type IA endoleak. Onyx was used to seal the gutter between the aortic wall and the endograft and the 1-month post-embolization CT showed complete sealing with no contrast in the sac. Two years after the rupture, he was presented again with clinical signs of hemodynamic shock and instability. An urgent CT Angiograph showed again rupture due to a type IA endoleak. The patient underwent an emergency open laparotomy. We analyze the re-rupture after EVAR while taking data from the literature into account.