bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supra‐Blan2t score as a multisystem‐based risk score to predict poor 3‐month outcome in acute ischemic stroke patients with intravenous thrombolysis
Authors: Jin Huijuan , Peng Qiwei , Li Min , Sun Shuai , Zhou Jinghua , Hu Jichuan , Huang Ming , Chen Xinglong , Li Yanan , Zhou Yifan , Wan Yan , Hong Candong , Chen Shengcai , Hu Bo 
Published: July 2023

AbstractAimTo develop and validate a novel weighted score integrating multisystem laboratory and clinical variables to predict poor 3‐month outcome (mRS score of 3–6) in acute ischemic stroke (AIS) patients with intravenous thrombolysis (IVT) therapy.MethodsWe retrospectively analyzed data from Trial of Revascularization Treatment for Acute Ischemic Stroke study. The Supra‐Blan2t score was derived using the data on age, the National Institutes of Health Stroke Scale score, history of atrial fibrillation, blood sugar level, neutrophil count, direct bilirubin level, platelet–lymphocyte ratio, and TnI level in the derivation cohort of 433 patients, and validated in a cohort of 525 patients. Furthermore, we compared the performance of the Supra‐Blan2t score with DRAGON, TURN, and SPAN‐100 scores.ResultsThe discrimination capacity in the derivation and validation cohorts was good for poor 3‐month outcome (the area under the curve was 0.821 and 0.843, respectively). The cumulative incidence of poor 3‐month outcome significantly increased across risk categories in the derivation (low‐risk, 9.2%; medium‐risk, 17.4%; and high‐risk, 58.8%) and validation cohorts (12.7%, 36.5%, and 73.6%, respectively). The performance of the Supra‐Blan2t score was similar to or superior to DRAGON, TURN, and SPAN‐100 scores.ConclusionThe Supra‐Blan2t score, based on easily available multisystem laboratory and clinical variables, reliably predicted poor 3‐month functional outcome in AIS patients treated with IVT therapy featuring good calibration and discrimination.
Tactile estimation of hedonic and sensory properties during active touch: An electroencephalography study
Authors: Henderson Jessica , Mari Tyler , Hewitt Danielle , Newton‐Fenner Alice , Hopkinson Andrew , Giesbrecht Timo , Marshall Alan , Stancak Andrej , Fallon Nicholas 
Published: July 2023

AbstractPerceptual judgements about our physical environment are informed by somatosensory information. In real‐world exploration, this often involves dynamic hand movements to contact surfaces, termed active touch. The current study investigated cortical oscillatory changes during active exploration to inform the estimation of surface properties and hedonic preferences of two textured stimuli: smooth silk and rough hessian. A purpose‐built touch sensor quantified active touch, and oscillatory brain activity was recorded from 129‐channel electroencephalography. By fusing these data streams at a single trial level, oscillatory changes within the brain were examined while controlling for objective touch parameters (i.e., friction). Time–frequency analysis was used to quantify changes in cortical oscillatory activity in alpha (8–12 Hz) and beta (16–24 Hz) frequency bands. Results reproduce findings from our lab, whereby active exploration of rough textures increased alpha‐band event‐related desynchronisation in contralateral sensorimotor areas. Hedonic processing of less preferred textures resulted in an increase in temporoparietal beta‐band and frontal alpha‐band event‐related desynchronisation relative to most preferred textures, suggesting that higher order brain regions are involved in the hedonic processing of texture. Overall, the current study provides novel insight into the neural mechanisms underlying texture perception during active touch and how this process is influenced by cognitive tasks.
Treatment‐responsive glycogen storage myopathy in a patient with POEMS syndrome: A new monoclonal gammopathy‐associated myopathy
Authors: Soontrapa Pannathat , Tracy Jennifer A. , Gonsalves Wilson I. , Liewluck Teerin 
Published: July 2023

AbstractBackgroundMyopathies associated with monoclonal gammopathy are relatively uncommon and underrecognized, treatable myopathies, and include sporadic late onset nemaline myopathy, light chain amyloid myopathy, and a recently described vacuolar myopathy with monoclonal gammopathy and stiffness (VAMGS). Herein, we report a new subtype of monoclonal gammopathy‐associated myopathy (MGAM) in a polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) patient.MethodCase report.ResultsA 51‐year‐old woman presented with a 6‐month history of progressive bilateral foot drop, lower limb edema, and a 15‐lb weight loss. She denied muscle stiffness. Neurologic exam showed severe distal weakness, mild proximal weakness, and length‐dependent sensory deficits. Laboratory studies revealed biclonal gammopathy (IgG kappa and IgA lambda), thrombocytosis, and elevated vascular endothelial growth factor. Creatine kinase was normal. Electrodiagnostic studies identified mixed demyelinating and axonal polyradiculoneuropathy and a superimposed proximal myopathy. Gluteus medius biopsy demonstrated scattered fibers with glycogen‐filled vacuoles, similar to VAMGS, with additional rare myofibers containing polyglucosan bodies. She was diagnosed with POEMS syndrome and concomitant glycogen storage myopathy. Next‐generation sequencing of glycogen storage and polyglucosan body myopathy‐related genes was unrevealing. Proximal weakness resolved after autologous stem cell transplant.ConclusionsThis patient expands a spectrum of MGAM. Recognition of this condition and other subtypes of MGAM is of utmost important because they are treatable.
Maternal upbringing and selective breeding for voluntary exercise behavior modify patterns of DNA methylation and expression of genes in the mouse brain
Authors: Latchney Sarah E. , Cadney Marcell D. , Hopkins Anthony , Garland Theodore 
Published: July 2023

AbstractSelective breeding has been utilized to study the genetic basis of exercise behavior, but research suggests that epigenetic mechanisms, such as DNA methylation, also contribute to this behavior. In a previous study, we demonstrated that the brains of mice from a genetically selected high runner (HR) line have sex‐specific changes in DNA methylation patterns in genes known to be genomically imprinted compared to those from a non‐selected control (C) line. Through cross‐fostering, we also found that maternal upbringing can modify the DNA methylation patterns of additional genes. Here, we identify an additional set of genes in which DNA methylation patterns and gene expression may be altered by selection for increased wheel‐running activity and maternal upbringing. We performed bisulfite sequencing and gene expression assays of 14 genes in the brain and found alterations in DNA methylation and gene expression for Bdnf, Pde4d and Grin2b. Decreases in Bdnf methylation correlated with significant increases in Bdnf gene expression in the hippocampus of HR compared to C mice. Cross‐fostering also influenced the DNA methylation patterns for Pde4d in the cortex and Grin2b in the hippocampus, with associated changes in gene expression. We also found that the DNA methylation patterns for Atrx and Oxtr in the cortex and Atrx and Bdnf in the hippocampus were further modified by sex. Together with our previous study, these results suggest that DNA methylation and the resulting change in gene expression may interact with early‐life influences to shape adult exercise behavior.
A mechanism of melanogenesis mediated by E‐cadherin downregulation and its involvement in solar lentigines
Authors: Inoue Daigo , Narita Tomomi , Ono Takayuki , Ishikawa Keiko , Maeno Katsuyuki , Aoki Hirofumi , Motoyama Akira , Shibata Takako 
Published: July 2023

AbstractObjectiveIntensive studies have revealed that pleiotropic melanocytic factors are associated with age‐spot formation. Dysfunctional keratinocyte differentiation is thought to be an upstream cause of age‐spot formation. Although it has been shown that keratinocyte differentiation is mediated by the cell–cell contact factor E‐cadherin, its involvement in age‐spot formation remains unknown. Thus, to determine the origin of age‐spots and an integrated solution for the same, we focused on E‐cadherin expression in the present study.MethodsFirst, we assessed the solar lentigines in cutaneous and cultured cells by means of immunofluorescence staining. Following that, keratinocytes treated with siRNAs against E‐cadherin were co‐cultured with melanocytes, and the secreted factors were identified by means of proteomic analysis of the culture supernatants. We also performed quantitative PCR to assess melanogenesis activity and screen ingredients. For behavioural analysis of melanocytes, we performed time‐lapse imaging using confocal laser scanning microscopy.ResultsE‐cadherin expression was downregulated in the epidermis of the solar lentigines, suggesting its involvement in age‐spot formation. E‐cadherin knocked down keratinocytes not only promoted the secretion of melanocytic/inflammatory factors but also increased melanogenesis by upregulating the expression of melanogenesis factors. Furthermore, live‐imaging showed that the downregulation of E‐cadherin inhibited melanocyte dynamics and accelerated melanin uptake. Finally, we identified Rosa multiflora fruit extract as a solution that can upregulate E‐cadherin expression in keratinocytes.ConclusionOur findings showed that E‐cadherin downregulation triggers various downstream melanocytic processes, such as the secretion of melanocytic factors and melanogenesis. Additionally, we showed that the Rosa multiflora fruit extract upregulated E‐cadherin expression in keratinocytes.
Predictive factors for postoperative medication therapy for overactive bladder symptoms after holmium laser enucleation of prostate
Authors: Kim Sung Jin , Park Sung Gon , Pak Sahyun , Kwon Ohseong , Lee Young Goo , Cho Sung Tae 
Published: July 2023

ObjectiveTo preoperative factors that could predict the persisting storage symptoms after Holmium laser enucleation of the prostate (HoLEP).MethodsMedical records of 257 patients who underwent HoLEP between December 2014 and January 2021 were reviewed. Participants with a follow‐up period exceeding 6 months were included. Preoperative data, including International Prostate Symptom Score (IPSS), uroflowmetry, prostate size, and prostate‐specific antigen, were collected. All participants underwent a preoperative urodynamic study. The correlation between perioperative variables and postoperative medication therapy (antimuscarinics or beta‐3 agonists) was assessed.ResultsOut of 257 participants in the study, 46 (18.6%) were allocated to the medication group, of which 25 (54.3%) initiated medication therapy postoperatively. The medication group showed worse postoperative IPSS storage symptom score and quality of life score compared to the medication‐free group (p = 0.048 and p = 0.002, respectively), but no significant differences were observed in complications or operative variables. In the de‐novo medication group, patients had lower preoperative Qmax, larger prostate volume, and smaller maximum cystometric capacity (MCC) compared to the persisting medication group (p = 0.020, p = 0.009, and p = 0.008, respectively). Overactive bladder (OAB) history, terminal detrusor overactivity (DO), and IPSS urgency item were identified as possible predictive factors for post‐HoLEP medication use.ConclusionsPreoperative factors such as OAB history, terminal DO, and IPSS urgency item may predict the need for post‐HoLEP medication therapy. Further follow‐up studies are warranted to understand the characteristics of the de‐novo medication group due to the significant discomfort it can cause to patients.
Machine translation in language acquisition: A study on EFL students' perceptions and practices in Saudi Arabia and South Korea
Authors: Almusharraf Asma , Bailey Daniel 
Published: July 2023

AbstractBackgroundLanguage learners are taking advantage of the increased accuracy afforded by machine translation (MT) tools like Google Translate. There is a growing debate as to whether these tools support or hinder English as a foreign language (EFL) education. Some EFL students are drawn to MT tools to save time and energy when communicating, but how this use relates to second language acquisition needs to be clarified.ObjectiveThis study investigated the perceptions and practices of MT tools among university EFL students in Saudi Arabia and South Korea.MethodsThe study surveyed Saudi (n = 310) and South Korean (n = 160) university students to explore the use of MT tools in EFL learning. It used mean scores, correlation analysis, and structural equation modelling to understand the perceived benefits and limitations of MT tools and their influence on the use of translation websites. The findings were triangulated using content analysis of open‐ended items.Results and ConclusionFindings indicate students showed a high level of acceptance and utilization of MT tools. English avoidance behaviour (B = 0.43), benefits (B = 0.32), and foreign language proficiency (B = −0.19) predicted 61% of actual use of MT tools like Google Translate. Further, students frequently used MT tools despite the reported concerns about accuracy mistakes. Saudi students listed a more comprehensive array of why they use MT tools than Korean students, while Saudis and Koreans frequently used MT tools for individual word and sentence translations.ImplicationsStudents should edit MT output when writing and are encouraged to use the voice recording and other functions of MT tools to learn language skills. Instructors must prevent overuse and dependency on MT tools, especially among low‐proficiency students who want to avoid using English.
Evaluation of custom posts and cores fabricated by two digital technologies in core and post space dimensions
Authors: Wu Yumin , Qi Haowen , Wang Danlei , Liao Mengyuan , Zhang Yuhang , Zhang Juan , Xie Haifeng 
Published: July 2023

AbstractPurposeTo evaluate the adaptability between posts and post spaces and the rationality of cores fabricated by two digital custom post‐and‐core processes.Materials and MethodsTitanium post‐and‐cores were fabricated by digital scanning impression technology or digital scanning wax‐pattern technology on tooth defect molds of incisors, premolars, and molars, with traditional lost‐wax casts of these teeth as the controls. Micro‐CT and a laboratory scanner were used to determine intervals between post wall and root canal wall of the root apex, middle, and cervix of each sample in cross‐, sagittal, and coronal sections; intervals between the end of post and tooth; diameters of cervical, middle, and incisal part at cross‐, sagittal, and coronal sections of each sample, as well as shoulder widths.ResultsThe three fabrication processes showed significant differences in intervals between post‐and‐core prostheses and root canal walls, diameters of all parts of cores, and shoulder widths. Scanning impressions showed significant advantages in the main part of post‐and‐cores in incisors and premolars, while the scanning wax‐pattern process showed obvious inferiorities in premolars and molars. As to core spatial size, values of measured sites in the scanning impression process were closer to the standard than those of the traditional process, while differences between the measured value of the scanning wax‐pattern process were much more obvious than in the traditional process.ConclusionsThe use of digital custom post‐and‐core scanning impressions improved the rationality and precision of post‐and‐core dimensions compared with two other processes.
Going it alone: Examining interpersonal sensitivity and hostility as mediators of the link between perfectionism and social disconnection
Authors: Visvalingam Shanara , Magson Natasha R. , Newins Amie R. , Norberg Melissa M. 
Published: July 2023

AbstractObjectivePerfectionism is linked to a variety of mental health conditions in university students. The Perfectionism Social Disconnection Model posits that perfectionistic individuals exhibit off‐putting interpersonal behaviors (i.e., rejection sensitivity and hostility), which lead to social disconnection, and in turn contribute to psychological distress. Although several longitudinal studies have found that social disconnection mediates the link between perfectionistic traits and psychological distress, less is known about how perfectionism leads to social disconnection. The present study aimed to address this gap.MethodsA sample of 877 university students completed one survey a month for three consecutive months.ResultsOur random‐intercept cross‐lagged panel model results showed significant positive associations between the random intercepts of socially prescribed and self‐oriented perfectionism with rejection sensitivity, hostility, and loneliness, with stronger associations for socially prescribed perfectionism. In addition, the random intercept of other‐oriented perfectionism showed positive associations with hostility but not rejection sensitivity or loneliness. Moreover, almost all cross‐lagged paths were nonsignificant.ConclusionCollectively, these findings indicate that although perfectionistic traits may be associated with rejection sensitivity and hostility to varying degrees at the between‐person level, these behaviors may not cause social disconnection at the within‐person level.
Religious Ethics as a Social Practice
Authors: Balthrop‐Lewis Alda 
Published: July 2023

ABSTRACTThe Journal of Religious Ethics (JRE) was established at a particular moment in the United States in the early 1970s. This article investigates how that moment—in the institutional milieu of academic theology and religious studies in which the (JRE) emerged—influenced its founding. It does this through attention to three main sources: (1) the original charter and bylaws of the JRE, (2) publications from the JRE and other scholarly outlets in the period, and (3) a collection of interviews with scholars who occupied editorial roles in the first 10 years of the life of the journal. The article suggests that the JRE's early period was driven by three key forces: the emergence of Christian ethics as a field of academic theology, deepening engagement with academic philosophy among students of Christian ethics, and growing attention to the pedagogical requirements of increasingly pluralist tertiary educational environments. In conclusion, I describe my own place in this history, asking how the dynamics around the founding of the JRE shape my participation in the practice enacted in its pages.
Are female CEOs associated with lower insolvency risk? Evidence from the US property‐casualty insurance industry
Authors: Li Jing , Cheng Jiang 
Published: July 2023

AbstractThis paper investigates the relationship between female CEOs and insolvency risk of US property‐casualty insurance companies. We show that female CEOs are associated with lower insurer insolvency propensity, higher z‐score, and lower standard deviation of return on assets. These findings are robust to alternative econometric specifications to address potential endogeneity concerns and self‐selection issues, including propensity score matching, the instrumental variable approach, and the difference‐in‐difference approach. Furthermore, we find that the impact of female CEOs on insurer insolvency risk is moderated by firm capitalization, the presence of female directors, and political conservatism of insurers' home states.
A blinded, placebo‐controlled study on the clinical effects of vitamin E supplementation in dogs with osteoarthritis
Authors: Gordon Casey L. , Reeves Samantha J. , Burchell Richard K. , Thomson Craig , Gal Arnon , Lopez‐Villalobos Nicolas , Webster Natalie S. L. , Litster Kimberley M. , Mitchell Richard A. S. 
Published: July 2023

AbstractBackgroundVitamin E has a positive effect in the management of osteoarthritis in humans, and in a previous study of dogs. It has been suggested to decrease C‐reactive protein concentrations and liver enzyme activities in humans and animals.ObjectiveTo assess the effect of vitamin E supplementation on lameness, pain, pain medication requirement, clinical pathology variables, and quality of life in large‐breed dogs with naturally occurring osteoarthritis.AnimalsFifty‐seven client‐owned dogs with naturally occurring osteoarthritis.MethodsDogs received either vitamin E or placebo for 90 days in a randomized, placebo‐controlled, double‐blinded, prospective clinical trial. Clinical lameness scores, pain medication requirements, and owner questionnaires were used to assess response to treatment every 30 days. Blood samples were collected at enrollment and at the end of the study period.ResultsVitamin E administration did not improve pain, lameness, or quality of life as assessed by owners and veterinarians. Vitamin E supplementation did not decrease the requirement for rescue pain relief. No changes in clinical pathology variables were observed after 90 days of vitamin E supplementation. Body weight was negatively associated with the lameness scores and requirement for rescue pain relief.ConclusionVitamin E supplementation did not have any observable positive effects in dogs with naturally occurring osteoarthritis.
Will social scientists’ never‐ending disputes over words ever end?
Authors: Abend Gabriel 
Published: July 2023

AbstractSocial science literatures are rife with disputes over their key words. I show that they tend to conflate two activities. One of them I call “word goes first!” It concerns word uses and how to appraise them. The other I call “distinction goes first!” It concerns distinctions and classifications and how to appraise them. For each activity, social science communities should get clear on what to do, what to circumvent, and what's at stake. I argue that both are practical reason activities. They should be partly driven by the common good, justice, and equality.
Non‐ossifying fibroma of the mandible: A case report and review of the literature
Authors: Clark Mollie , Brierley Daniel J. , Chan Chi‐Hwa , Hughes David , Shadid Omar 
Published: July 2023

AbstractThe case reported here is a large non‐ossifying fibroma (NOF) of the mandible presenting in a 24‐year‐old male patient. The lesion was diagnosed through radiological and histopathological assessment. It remains under observation without surgical intervention, despite its large size, as the extensive surgery to remove it is not currently justifiable. Whilst common at the metaphysis of the long bones in paediatric patients, NOFs are rarely observed in the jaw bones. These benign fibrous lesions are often asymptomatic and may be an incidental radiological finding. Most NOFs of the limbs presenting in children will not require any treatment, and spontaneously resolve when growth ceases. However, regarding mandibular lesions, the majority of historical cases have been successfully treated with curettage and do not recur. Due to their scarcity, the outcomes for untreated NOFs of the gnathic bones are not reliably known. We discuss the clinical, radiological and histopathological findings for this case. A thorough literature review of previous reports of this rare entity reveals the typical characteristics and behaviour of this lesion.