bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children and young peoples’ lyrics and voices capturing their experiences within youth justice services
Authors: Price Jayne , Wilkinson Dean , Crossley Charlene 
Published: April 2023

PurposeThis paper aims to explore young peoples’ authentic experiences of youth justice services (YJS) during the Covid-19 pandemic. By adopting the creative arts-based method of lyric writing, the research team sought to empower participants through collaboration and participation and to facilitate them leading the narrative (Deakinet al., 2020).Design/methodology/approachThis research adopted a creative arts-based method in which participants worked alongside an artist to generate lyrics that captured their experiences within YJS. Such an approach demonstrated a commitment to participatory, child-first approaches.FindingsTwo main themes were identified: identity and relationships. The young people vocalised resistance to frequent labelling and their ambitions to move away from past criminal identity and behaviour. Relationships with practitioners could be a source of frustration within this but were also highlighted as valuable and supportive.Research limitations/implicationsAs data collection was remote, owing to the Covid-19 pandemic and associated lockdowns, the opportunity to develop relationships with young people within the YJS prior to conducting the research was restricted. This approach may have also impacted recruitment of participants. The sessions presented short-term interventions and whilst follow-up sessions were offered, many did not take them up. Although the research sample is small and cannot be considered representative, it allows for a valuable insight into the experiences of young people at a particularly challenging time.Practical implicationsUpon receiving our findings and recommendations, the first YJS research site has sought to further embed a relationship-based practice model and greater creative/participatory socially prescribed psychosocial therapeutic interventions, including music groups and spoken word artists to work with children and young people.Originality valueThis research adds to the growing literature base surrounding creative arts-based research with children and young people for their value towards communication, pro-social identity and development.
Effect of inclination angle on the thermal-hydraulic characteristics and entropy generation of Al2O3–water nanofluid for in-tube turbulent flow
Authors: Chinakwe Chinedu , Adelaja Adekunle , Akinseloyin Michael , Olakoyejo Olabode Thomas 
Published: April 2023

Purpose
Inclination angle has been reported to have an enhancing effect on the thermal-hydraulic characteristics and entropy of some thermal systems. Therefore, this paper aims to numerically investigate the effects of inclination angle, volume concentration and Reynolds number on the thermal and hydraulic characteristics and entropy generation rates of water-based Al2O3 nanofluids through a smooth circular aluminum pipe in a turbulent flow.

Design/methodology/approach
A constant heat flux of 2,000 Watts is applied to the circular surface of the tube. Reynolds number is varied between 4,000 and 20,000 for different volume concentrations of alumina nanoparticles of 0.5%, 1.0% and 2.0% for tube inclination angles of ±90o, ±60o, ±45o, ±30o and 0o, respectively. The simulation is performed in an ANSYS Fluent environment using the realizable kinetic energy–epsilon turbulent model.

Findings
Results show that +45o tube orientation possesses the largest thermal deviations of 0.006% for 0.5% and 1.0% vol. concentrations for Reynolds numbers 4,000 and 12,000. −45o gives a maximum pressure deviation of −0.06% for the same condition. The heat transfer coefficient and pressure drop give maximum deviations of −0.35% and −0.39%, respectively, for 2.0% vol. concentration for Reynolds number of 20,000 and angle ±90o. A 95%–99.8% and 95%–98% increase in the heat transfer and total entropy generation rates, respectively, is observed for 2.0% volume concentration as tube orientation changes from the horizontal position upward or downward.

Originality/value
Research investigating the effect of inclination angle on thermal-hydraulic performance and entropy generation rates in-tube turbulent flow of nanofluid is very scarce in the literature.
Do ‘humble’ leaders help employees to perform better? Evidence from the Chinese public sector
Authors: Wu Fan , Zhou Qiwei 
Published: April 2023

AbstractHumility is crucial for public sector leaders as it enables them to recognise their inadequacies and acknowledge others’ competencies in complex external environments. Despite its benefits, our knowledge of the influence of leader humility in the public sector remains limited. This study provides insights into how and when leader humility influences employee performance in public sectors. Based on Self‐Determination Theory, this article posits that leader humility enhances the leader's perception of employee performance by promoting intrinsic motivation. Moreover, drawing on Dominance Complementarity Theory, it is revealed that the above effect is stronger when the employee has a highly proactive personality. To assess the mechanism and boundary condition of leader humility on the perception of employee performance, our study uses a two‐wave multi‐source survey of 136 leader–employee dyads amongst public sector workers located in north‐eastern China. The results are consistent with our theoretical predictions. We discuss implications for understanding how public leader humility influences employees’ motivation and subsequent performance, and how a leader's character and an employee's personality may enhance desirable outcomes.Points for practitioners
Humble public leaders can satisfy their followers’ basic self‐determining psychological needs and improve followers’ intrinsic motivations.
Since humble public leaders care more about others and can minimise the effect of leader–follower power imbalances, facilitate frequent interactions, and spotlight followers’ unique abilities, they tend to enhance the followers’ job performance through their increased intrinsic motivation.
Humble public leaders are non‐hierarchical and power equalising. They could positively interact with proactive followers who tend to take the initiative to get things done. The interaction facilitates followers’ higher intrinsic motivation and job performance.
One Man's Damage: The Consequences of Boris Johnson's Assault on the British Political System
Authors: Sanders David 
Published: April 2023

AbstractThe disgraced British prime minister, Boris Johnson, was forced to resign by his own backbench MPs on 7 July 2022 (effective from 6 September) in complete denial that he had done anything wrong. Optimists might argue that this shows the strength of the British political system; that a way was found to throw out a proven rascal, thus providing the opportunity for a restoration of ‘normal politics’. In my view, this optimism is misplaced. Boris Johnson's behaviour, mirroring that of his populist role model, Donald Trump, has raised a number of serious questions about the continued successful functioning of the UK's unwritten constitution.The article reviews the character of Johnson's constitutional violations during his period as prime minister. Using data from a recent survey of UK voters, it then explores the damaging effect that his period in office has had on UK public opinion. Despite his removal from office, Johnson retains a hard core of support across the wider electorate and, in particular, among grassroots Conservative supporters and party members. These supporters remain largely unaware of Johnson's constitutional crimes, and where they do know about them, they forgive them. This creates the real danger either that Johnson may at some future date return to office to repeat his offences, or that a similarly populist successor might deploy the same anti‐democratic devices that Johnson himself used in his desperate attempts to cling to power.
Devouring and Asphyxia: Paradigm Crisis, the Depletion of the Hero and Complex Thought1
Authors: Boechat Walter 
Published: April 2023

AbstractThis article deals with the profound paradigm crisis that affects modernity and threatens the destiny of humanity. This crisis results from the lack of perspective offered by the paradigm of modernity with its emphasis on unilateral rationality, scientific objectivity, and exploitation of natural resources by a hyper development of an inflated Hero archetype. The emergence of a new paradigm of complexity, C. G. Jung’s complex psychology, and Ameridian perspectivism, may offer new paths to approach these serious problems lived by modern man. A clinical vignette illustrates how complex psychology may also help with individual patients suffering from psychosomatic complaints.
Wheat starch structure–function relationship in breadmaking: A review
Authors: van Rooyen Jana , Simsek Senay , Oyeyinka Samson A. , Manley Marena 
Published: April 2023

AbstractBread dough and bread are dispersed systems consisting of starch polymers that interact with other flour components and added ingredients during processing. In addition to gluten proteins, starch impacts the quality characteristics of the final baked product. Wheat starch consists of amylose and amylopectin organized into alternating semicrystalline and amorphous layers in granules that vary in size and are embedded in the endosperm protein matrix. Investigation of the molecular movement of protons in the dough system provides a comprehensive insight into granular swelling and amylose leaching. Starch interacts with water, proteins, amylase, lipids, yeast, and salt during various stages of breadmaking. As a result, the starch polymers within the produced crumb and crust, together with the rate of retrogradation and staling due to structural reorganization, moisture migration, storage temperature, and relative humidity determines the final product's textural perception. This review aims to provide insight into wheat starch composition and functionality and critically review recently published research results with reference to starch structure–function relationship and factors affecting it during dough formation, fermentation, baking, cooling, and storage of bread.
Utilization of plant extracts to control the safety and quality of fried foods—A review
Authors: Li Cuicui , Chen Long , McClements David Julian , Liu Wenmeng , Long Jie , Qiu Chao , Wang Yi , Yang Zhongyu , Xu Zhenlin , Meng Man , Jin Zhengyu 
Published: April 2023

AbstractFrying is one of the most common methods of preparing foods. However, it may lead to the formation of potentially hazardous substances, such as acrylamide, heterocyclic amines, trans fatty acids, advanced glycation end products, hydroxymethyl furfural and polycyclic aromatic hydrocarbons, and adversely alter the desirable sensory attributes of foods, thereby reducing the safety and quality of fried foods. Currently, the formation of toxic substances is usually reduced by pretreatment of the raw materials, optimization of process parameters, and the use of coatings. However, many of these strategies are not highly effective at inhibiting the formation of these undesirable reaction products. Plant extracts can be used for this purpose because of their abundance, safety, and beneficial functional attributes. In this article, we focus on the potential of using plant extracts to inhibit the formation of hazardous substances, so as to improve the safety of fried food. In addition, we also summarized the effects of plant extracts, which inhibit the production of hazardous substances, on food sensory aspects (flavor, color, texture, and taste). Finally, we highlight areas where further research is required.
Clinical impact of first‐line PD‐1 or PD‐L1 inhibitors combined with chemotherapy in extensive‐stage small cell lung cancer patients: A real‐world multicenter propensity score‐matched study
Authors: Xie Jingyuan , Chen Mo , Han Hedong , Xu Ke , Qiu Guihuan , Lin Xinqing , Song Yong , Ye Jinjun , Lv Tangfeng , Zhan Ping 
Published: April 2023

AbstractObjectivesOur research aimed to evaluate the effectiveness of first‐line immune checkpoint inhibitors (ICIs) with etoposide and platinum (EP) for extensive‐stage small cell lung cancer (ES‐SCLC) and identify prognostic factors, as real‐world outcomes and the inconsistency of PD‐1 and PD‐L1 inhibitors are uncertain.MethodsWe selected ES‐SCLC patients in three centers and conducted a propensity score‐matched analysis. The Kaplan–Meier method and Cox proportional hazards regression were conducted to compare the survival outcomes. We also performed univariate and multivariate Cox regression analyses to investigate predictors.ResultsAmong 236 patients included, 83 pairs of cases were matched. The EP plus ICIs cohort had a longer median overall survival (OS) (17.3 months) than the EP cohort (13.4 months) (hazard ratio [HR],  0.61 [0.45, 0.83]; p = 0.001). The median progression‐free survival (PFS) was also longer in the EP plus ICIs cohort (8.3 months) than in the EP cohort (5.9 months) (HR,   0.44 [0.32, 0.60]; p < 0.001). The EP plus ICIs group had a higher objective response rate (ORR) (EP: 62.3%, EP + ICIs: 84.3%, p < 0.001). Multivariate analysis presented that liver metastases (HR, 2.08; p = 0.018) and lymphocyte–monocyte ratio (LMR) (HR, 0.54; p = 0.049) were independent prognostic factors for OS, and performance status (PS) (HR, 2.11; p = 0.015), liver metastases (HR, 2.64; p = 0.002), and neutrophil‐lymphocyte ratio (NLR) (HR, 0.45; p = 0.028) were for PFS in patients with chemo‐immunotherapy.ConclusionOur real‐world data demonstrated that ICIs with chemotherapy as the first‐line setting for ES‐SCLC are effective and safe. PS, liver metastases, and inflammatory markers could serve as valuable risk factors.
Influence of vaccination on adverse health outcomes after SARS‐CoV‐2 infection among individuals with alcohol use disorder: a population‐based study
Authors: Askgaard Gro , Osler Merete , Laursen Thomas Munk , Hjorthøj Carsten , Benros Michael E. , Ethelberg Steen , Mølbak Kåre , Nordentoft Merete , Nilsson Sandra Feodor 
Published: April 2023

AbstractBackground and AimsAlcohol use disorders (AUD) have not been included in the priority groups for early vaccine against SARS‐CoV‐2. We aimed to determine adverse outcomes after SARS‐CoV‐2 infection among individuals with AUD and how this is modified by vaccination.Design, Setting and ParticipantsThis was a registry‐based cohort study carried out in Denmark, 27 February 2020 to 15 October 2021, comprising 2157 individuals with AUD and 237 541 without AUD who had had a polymerase chain reaction (PCR)‐confirmed SARS‐CoV‐2 infection during the study period.MeasurementsThe association of AUD with the absolute and relative risk of hospitalization, intensive care and 60‐day mortality after SARS‐CoV‐2 infection and of all‐cause mortality throughout the follow‐up period were measured. Potential interactions with SARS‐CoV‐2 vaccination, education and sex were explored in stratified analyses and tested by including interaction terms and using likelihood ratio tests.FindingsIndividuals with AUD had an increased absolute and relative risk of adverse outcomes, including hospitalization [incidence rate ratio (IRR) = 1.72, 95% confidence interval (CI) = 1.51–1.95], intensive care (IRR = 1.47, 95% CI = 1.07–2.02) and 60‐day mortality [mortality rate ratio (MRR) = 2.35, 95% CI = 1.94–2.85] compared with SARS‐CoV‐2‐positive individuals without AUD. Irrespective of AUD, highest risks of these adverse health outcomes were observed for individuals not vaccinated against SARS‐CoV‐2 infection, for individuals of low educational level and in males. However, for all‐cause mortality throughout the follow‐up period, SARS‐CoV‐2 infection showed a lower relative mortality risk increase, whereas being unvaccinated showed a higher relative mortality risk increase, in individuals with AUD than in the reference population without AUD (P of interaction tests < 0.0001).ConclusionsBoth alcohol use disorder and being unvaccinated for SARS‐CoV‐2 appear to be independent risk factors for adverse health outcomes following SARS‐CoV‐2 infection.
Effect of CYP3A4 induction and inhibition on the pharmacokinetics of SHR0302 in healthy subjects
Authors: Zhang Zhe , Gao Xuehu , Zhang Ping , Li Yuan , Fu Meng , Lin Hongda , Feng Sheng , Shen Kai , Yu Guoning , Li Xin 
Published: April 2023

AimsSHR0302 is a selective Janus kinase (JAK) 1 inhibitor under clinical investigation for the treatment of rheumatoid arthritis (RA). As SHR0302 is metabolized mainly by cytochrome P450 (CYP) 3A4, clinical studies were performed to evaluate the effects of a strong CYP3A4 inducer, rifampin, and a strong CYP3A4 inhibitor, itraconazole, on the pharmacokinetics of SHR0302 in healthy subjects.MethodsTwo phase I, open‐label, fixed‐sequence drug interaction studies enrolled 28 subjects. In Study A, 14 subjects received 8 mg SHR0302 on Days 1 and 10, and 600 mg rifampin once daily on Days 3–11. In Study B, 14 subjects received 4 mg SHR0302 on Days 1 and 8, and 200 mg itraconazole once daily on Days 4–10. Blood samples were collected to measure SHR0302 concentrations. Pharmacokinetic parameters were calculated using non‐compartmental analysis. Treatment comparisons were made using mixed‐effect models.ResultsCo‐administration with rifampin decreased the exposures of SHR0302 with geometric mean ratios (GMRs) (90% confidence intervals [CIs]) for AUC0‐inf of 0.51 (0.49, 0.54) and Cmax of 0.91 (0.84, 0.98). Co‐administration with itraconazole increased the exposures of SHR0302 with GMR (90% CIs) for AUC0‐inf of 1.48 (1.41, 1.56) and Cmax of 1.06 (0.982, 1.14). Single oral doses of SHR0302 administered with or without rifampin or itraconazole were generally safe.ConclusionsStrong CYP3A4 induction and inhibition both resulted in a weak effect on the clinical exposures of SHR0302. These present studies provided valuable information that helps inform SHR0302 dosing instructions and concomitant medication precautions.
A reflective design case of practical micro‐ethics in learning analytics
Authors: Knight Simon , Shibani Antonette , Buckingham Shum Simon 
Published: April 2023

AbstractA burgeoning literature, policy landscape, and set of practice resources and guidelines have emerged around ethical educational technology development and implementation, particularly in the context of data or artificial intelligence informed tools. However, while these resources provide valuable tools to support navigation of the ethical landscape, they suffer from some limitations. These include a focus on coarse‐grained, clear cut cases; a lack of attention to dilemmas and tensions; and a potential focus on procedural aspects of ethics, rather than our moment‐to‐moment ethics‐in‐action. This paper provides a case study description, using a reflective design case to provide a more textured micro‐ethics. The case approach, its exemplification as a tool for micro‐ethics, and the features of interest in our particular case each provide valuable tools for the educational technology community.
Practitioner notesWhat is already known about this topic

Ethical concerns are central to the design, development and implementation of educational technologies (edtech).

A range of guidelines, policies and law exist, providing principles that guide edtech research and use.

However existing resources tend to reflect coarse procedural aspects of ethics, providing a navigation aid, but not a defined path, in ethical edtech practice.

What this paper adds

This paper provides a novel method—a reflective design case—for describing and exploring micro‐ethics in edtech.

Through applying this method, we demonstrate that micro‐ethical analyses of ‘ethics‐in‐action’ help to uncover the nuanced decisions we make in ethical conduct.

This exemplification provides insight into a specific body of work on writing analytics, of relevance to the field.

Implications for practice and/or policy

Policy and guidance for ethical conduct should make use of cases that demonstrate how such ethical materials are drawn on in ethical conduct, and as demonstrations of micro‐ethics in action.

Practitioners—those who design, develop, and implement edtech—may use the method developed to explore and share their own cases to support their work.

Practitioners—those who design, develop, and implement edtech—may draw on shared reflective design cases in learning regarding navigating application of procedural ethics and developing ethics‐in‐action.
Systematic review and meta‐analysis of the clinical effectiveness of tixagevimab/cilgavimab for prophylaxis of COVID‐19 in immunocompromised patients
Authors: Suribhatla Rhea , Starkey Thomas , Ionescu Maria C. , Pagliuca Antonio , Richter Alex , Lee Lennard Y. W. 
Published: April 2023

SummaryImmunocompromised patients, such as those with a haematological malignancy, are at higher risk of SARS‐CoV‐2 infection, severe outcomes and mortality. Tixagevimab/cilgavimab is a monoclonal antibody combination which binds to the SARS‐CoV‐2 spike protein. The PROVENT phase III clinical trial reported that tixagevimab/cilgavimab prophylaxis significantly reduced the risk of COVID‐19 infection in immunocompromised participants. However, the trial was conducted before the Omicron variant became prevalent. This systematic review and meta‐analysis provide an up‐to‐date summary of the real‐world effectiveness of tixagevimab/cilgavimab in immunocompromised patients, including patients with haematological malignancies. Clinical studies from 1 January 2021 to 1 October 2022, which reported breakthrough COVID‐19 infections after tixagevimab/cilgavimab, were included. COVID‐19‐related hospitalisations, intensive care admissions and mortality were also assessed. A meta‐analysis was performed to ascertain overall clinical effectiveness. Eighteen studies, with 25 345 immunocompromised participants, including 5438 patients with haematological pathologies, were included in the review. The overall clinical effectiveness of tixagevimab/cilgavimab against COVID‐19 breakthrough infection, hospitalisation, intensive care admission and COVID‐19‐specific mortality was 40.54%, 66.19%, 82.13% and 92.39%, respectively. This review highlights the clinical effectiveness of tixagevimab/cilgavimab at reducing COVID‐19 infection and severe outcomes for immunosuppressed individuals, including patients with a haematological malignancy, during the Omicron‐predominant era. Real‐world studies are important to provide ongoing certainty of the clinical benefit for immunocompromised patients against new SARS‐CoV‐2 variants.