bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes as a risk factor for the onset of frozen shoulder: a systematic review and meta-analysis
Authors: Dyer Brett Paul , Rathod-Mistry Trishna , Burton Claire , van der Windt Danielle , Bucknall Milica 
Published: January 2023

ObjectiveSummarise longitudinal observational studies to determine whether diabetes (types 1 and 2) is a risk factor for frozen shoulder.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, Embase, AMED, PsycINFO, Web of Science Core Collection, CINAHL, Epistemonikos, Trip, PEDro, OpenGrey and The Grey Literature Report were searched on January 2019 and updated in June 2021. Reference screening and emailing professional contacts were also used.Eligibility criteriaLongitudinal observational studies that estimated the association between diabetes and developing frozen shoulder.Data extraction and synthesisData extraction was completed by one reviewer and independently checked by another using a predefined extraction sheet. Risk of bias was judged using the Quality In Prognosis Studies tool. For studies providing sufficient data, random-effects meta-analysis was used to derive summary estimates of the association between diabetes and the onset of frozen shoulder.ResultsA meta-analysis of six case–control studies including 5388 people estimated the odds of developing frozen shoulder for people with diabetes to be 3.69 (95% CI 2.99 to 4.56) times the odds for people without diabetes. Two cohort studies were identified, both suggesting diabetes was associated with frozen shoulder, with HRs of 1.32 (95% CI 1.22 to 1.42) and 1.67 (95% CI 1.46 to 1.91). Risk of bias was judged as high in seven studies and moderate in one study.ConclusionPeople with diabetes are more likely to develop frozen shoulder. Risk of unmeasured confounding was the main limitation of this systematic review. High-quality studies are needed to confirm the strength of, and understand reasons for, the association.PROSPERO registration numberCRD42019122963.
Heartwatch: an Irish cardiovascular secondary prevention programme in primary care, a secondary analysis of patient outcomes
Authors: Homeniuk Robyn , Stanley Fintan , Gallagher Joseph , Collins Claire 
Published: January 2023

ObjectivesTo investigate patient follow-up data from Heartwatch: Ireland’s secondary prevention programme for cardiovascular disease delivered in general practice.DesignRetrospective descriptive study based on secondary analysis of routinely collected data from Heartwatch.SettingHeartwatch targeted 20% of general practices in Ireland and recruited 475 general practitioners across 325 practices.ParticipantsThe patient population included people with a history of acute myocardial infarction, percutaneous transluminal coronary angioplasty or a coronary artery bypass graft. Over 16 000 patients entered the programme however, to assess the long-term progress of patients, we identified a cohort of 5700 patients with at least 8 years in the programme.InterventionsA standard protocol for continuing care of patients for the secondary prevention of cardiovascular disease was administered by general practices. The programme was designed using WHO and European Society of Cardiology guidelines on secondary prevention.Outcome measuresA Continuing Care (CCare) score out of eight was the primary outcome measure used. It was calculated based on programme targets for well-known cardiovascular risk factors: exercise, systolic blood pressure, LDL cholesterol, optimally controlled glucose, smoking status, and pharmacological treatment.ResultsAfter 1 year, 37% of the 8-year cohort had achieved a CCare score >5 increasing to 44% after year 8. Patient sex was predictive of better scores; male patients had almost a half-point advantage (0.432, 99% CI: 0.335 to 0.509). Patients who enrolled earlier following their qualifying event and patients with more frequent visits were also more likely to achieve higher CCare scores.ConclusionsOverall, patients are not likely to meet all targets set by secondary prevention guidelines, however, supporting patient self-management may impact on this. Early enrolment after a cardiac event and frequent structured care visits should be priorities in the design and implementation of similar programmes. Ongoing evaluation of them is necessary to improve outcomes.
Mediating effects of psychological capital on the relationship between workplace violence and professional identity among nurses working in Chinese public psychiatric hospitals: a cross-sectional study
Authors: Chang Tiantian , Jiang Xiaoyu , Wei Junlin , Zhao Jinghua , Li Zhiqiang , Li Hongli 
Published: January 2023

ObjectiveTo examine the relationship between workplace violence (WPV) and professional identity among Chinese psychiatric nurses and the mediating effects of psychological capital (PsyCap) from this association.SettingSeven public tertiary psychiatric hospitals in Liaoning Province, China.ParticipantsA total of 952 psychiatric nurses were recruited for this study. Registered nurses who have been engaged in psychiatric nursing for more than 1 year were eligible as participants in this investigation.Outcome measuresQuestionnaires consisting of the Workplace Violence Scale, the Occupational Identity Scale, the Psychological Capital Questionnaire and a demographic data sheet were used to collect participant information. We used hierarchical multiple regression and asymptotic and resampling strategies to examine the mediating role of PsyCap in the relationship between WPV and professional identity.ResultsWPV was negatively associated with professional identity after controlling for demographic factors (β=−0.353; p<0.001). PsyCap mediated the relationship between WPV and professional identity, according to the mediation analysis (a×b=−0.150, bias-corrected and accelerated 95% CI (BCa 95% CI) (−0.185 to −0.115); p<0.001). In addition, two dimensions of PsyCap: hope (a×b=−0.075, BCa 95% CI (−0.104 to −0.049); p<0.001) and resilience (a×b=−0.064, BCa 95% CI (−0.090 to −0.039); p<0.001) mediated the association between WPV and professional identity. For professional identity, hope, resilience and PsyCap mediation accounted for 21.6%, 18.1% and 42.4%, respectively.ConclusionsBased on these findings, PsyCap could partially mediate the relationship between WPV and professional identity. Therefore, hospital administrators should implement measures to prevent and reduce WPV and provide nurses with skills training programmes to improve the PsyCap such as hope and resilience.
Public perceptions on the application of artificial intelligence in healthcare: a qualitative meta-synthesis
Authors: Wu Chenxi , Xu Huiqiong , Bai Dingxi , Chen Xinyu , Gao Jing , Jiang Xiaolian 
Published: January 2023

ObjectivesMedical artificial intelligence (AI) has been used widely applied in clinical field due to its convenience and innovation. However, several policy and regulatory issues such as credibility, sharing of responsibility and ethics have raised concerns in the use of AI. It is therefore necessary to understand the general public’s views on medical AI. Here, a meta-synthesis was conducted to analyse and summarise the public’s understanding of the application of AI in the healthcare field, to provide recommendations for future use and management of AI in medical practice.DesignThis was a meta-synthesis of qualitative studies.MethodA search was performed on the following databases to identify studies published in English and Chinese: MEDLINE, CINAHL, Web of science, Cochrane library, Embase, PsycINFO, CNKI, Wanfang and VIP. The search was conducted from database inception to 25 December 2021. The meta-aggregation approach of JBI was used to summarise findings from qualitative studies, focusing on the public’s perception of the application of AI in healthcare.ResultsOf the 5128 studies screened, 12 met the inclusion criteria, hence were incorporated into analysis. Three synthesised findings were used as the basis of our conclusions, including advantages of medical AI from the public’s perspective, ethical and legal concerns about medical AI from the public’s perspective, and public suggestions on the application of AI in medical field.ConclusionResults showed that the public acknowledges the unique advantages and convenience of medical AI. Meanwhile, several concerns about the application of medical AI were observed, most of which involve ethical and legal issues. The standard application and reasonable supervision of medical AI is key to ensuring its effective utilisation. Based on the public’s perspective, this analysis provides insights and suggestions for health managers on how to implement and apply medical AI smoothly, while ensuring safety in healthcare practice.PROSPERO registration numberCRD42022315033.
Effectiveness of non-pharmacological treatments for postpartum depression: an umbrella review protocol
Authors: Lu Xiaofei , Yang Zhuoxin , Liu Fan , Zhou Yumei , Xu Yuqin , Zhuo Yuanyuan , Huang Xingxian , Gong Mingqiang 
Published: January 2023

IntroductionNon-pharmacological treatments for postpartum depression have been investigated in various systematic reviews, and their efficacy has been evaluated. However, the quality of the evidence as a whole has not been quantified. The quality of this evidence may influence the choice of interventions and even cause misleading clinical decisions. This study aims to provide an objective presentation of the methodological bias and identify treatments supported by solid evidence.Methods and analysisFor the purpose of conducting systematic reviews and meta-analyses, a comprehensive search of the relevant published literature will be conducted in English databases such as PubMed, Embase, Cochrane Library, PsycINFO and Scopus, as well as in four Chinese databases: the Chinese Biomedical Databases (CBM), Wan fang database, China National Knowledge Infrastructure and VIP Database (VIP). The time of publication will be limited from their inception to 31 May 2022. We will extract the following data from the included literature: title, first author, journal type of included literature, number and sample size, intervention/control measures, outcome indicators and main study outcomes. The Assessment of Multiple Systematic Reviews-2 will be used to measure the quality of the methods. In addition, we will use the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement to evaluate the quality of the reporting, as well as the Grading of Recommendations Assessment, Development and Evaluation to evaluate the quality of the evidence.PROSPERO registration numberCRD42021285470.
Do expectations determine postoperative disability in women with endometriosis? Study protocol for a clinical mixed-methods observational cohort study
Authors: Hirsing Nina , Meyrose Ann-Katrin , Buchweitz Olaf , Nestoriuc Yvonne 
Published: January 2023

IntroductionOverall, 20%–30% of women with endometriosis report endometriosis-related disability after successful laparoscopy. This indicates a potential impact of psychological factors, such as expectations, on treatment outcomes. It is already known that expectations determine treatment outcomes in various health conditions, such as cardiologic or gynaecology. Therefore, we investigate the impact of expectations and other psychological factors on patients’ course of treatment outcomes after laparoscopy.Methods and analysisA longitudinal mixed-methods study with N=300 women treated at a specialised centre of surgical endoscopy and endometriosis will be conducted with one preoperative and eight postoperative assessments of endometriosis-related disability and a priori specified predictors such as expectations.Additionally, two subsamples (each ~n=30) will be either interviewed about their endometriosis-related disability, expectations, and experiences of laparoscopy before and after surgery or asked once per day for 30 consecutive days using ambulatory assessments. Quantitative data will be analysed using multilevel modelling for longitudinal data. Structural content analysis will be used for qualitative data.DiscussionTo optimise treatment for women with endometriosis, it is essential to understand how treatment expectations and other psychological and medical factors influence treatment outcomes after laparoscopy.Ethics and disseminationThe Ethics Committee of the Psychotherapeutenkammer Hamburg, Germany, gave ethical approval (ROXWELL-2021-HH, 25 June 2021).Trial registration numberClinicalTrials.gov Registry (NCT05019612).
Using co-design to improve the client waiting experience at an outpatient mental health clinic
Authors: Darkwa Maame , Engel Katrina , Findlay Zoe , Voyer Anne-Marie , Waddell Andrea E 
Published: January 2023

Prolonged wait times in healthcare are a complex issue that can negatively impact both clients and staff. Longer wait times are often caused by a number of factors such as overly complicated scheduling, inefficient use of resources, extraneous processes, and misalignment of supply and demand. Growing evidence suggests a correlation between wait times and client satisfaction. This relationship, however, is complex. Some research suggests that client satisfaction with wait times may be improved with interventions that enhance the waiting experience and not actual wait times. This project aimed to improve the average daily rating of the client waiting experience by 1 point on a 7-point Likert scale.A quality improvement study was conducted to analyse client satisfaction with wait times and enhance clients’ satisfaction while waiting. Quality improvement methods, mainly co-design sessions, were used to co-create and implement an intervention to improve clients’ experience with waiting in the clinic.The project resulted in the implementation of a whiteboard intervention in the clinic to inform clients where they are in the queue. The whiteboard also included static data summarising the average wait times from the previous month. Both aspects of the whiteboard were designed to allow patients to better approximate their wait times. Though the quantitative analysis did not reveal a 1-point improvement on a 7-point Likert scale, the feedback from staff and clients was positive. Since implementation, clinic staff and management have developed the intervention into a high-fidelity digital board that is still in use today. Furthermore, the use of the intervention has been extended locally, with additional ambulatory clinics at the hospital planning to use the set-up in their clinic waiting rooms.
Survey of liver pathologists to assess attitudes towards digital pathology and artificial intelligence
Authors: McGenity Clare , Randell Rebecca , Bellamy Christopher , Burt Alastair , Cratchley Alyn , Goldin Robert , Hubscher Stefan G , Neil Desley A H , Quaglia Alberto , Tiniakos Dina , Wyatt Judy , Treanor Darren 
Published: January 2023

AimsA survey of members of the UK Liver Pathology Group (UKLPG) was conducted, comprising consultant histopathologists from across the UK who report liver specimens and participate in the UK National Liver Pathology External Quality Assurance scheme. The aim of this study was to understand attitudes and priorities of liver pathologists towards digital pathology and artificial intelligence (AI).MethodsThe survey was distributed to all full consultant members of the UKLPG via email. This comprised 50 questions, with 48 multiple choice questions and 2 free-text questions at the end, covering a range of topics and concepts pertaining to the use of digital pathology and AI in liver disease.ResultsForty-two consultant histopathologists completed the survey, representing 36% of fully registered members of the UKLPG (42/116). Questions examining digital pathology showed respondents agreed with the utility of digital pathology for primary diagnosis 83% (34/41), second opinions 90% (37/41), research 85% (35/41) and training and education 95% (39/41). Fatty liver diseases were an area of demand for AI tools with 80% in agreement (33/41), followed by neoplastic liver diseases with 59% in agreement (24/41). Participants were concerned about AI development without pathologist involvement 73% (30/41), however, 63% (26/41) disagreed when asked whether AI would replace pathologists.ConclusionsThis study outlines current interest, priorities for research and concerns around digital pathology and AI for liver pathologists. The majority of UK liver pathologists are in favour of the application of digital pathology and AI in clinical practice, research and education.
T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins
Authors: Schlichtner Stephanie , Yasinska Inna M , Lall Gurprit S , Berger Steffen M , Ruggiero Sabrina , Cholewa Dietmar , Aliu Nijas , Gibbs Bernhard F , Fasler-Kan Elizaveta , Sumbayev Vadim V 
Published: January 2023

BackgroundGalectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. Recent evidence demonstrated that galectin-9 is highly expressed in a wide range of human malignancies including the most aggressive tumors, such as high-grade glioblastomas and pancreatic ductal adenocarcinomas, as well as common malignancies such as breast, lung and colorectal cancers. However, solid tumor cells at rest are known to secrete either very low amounts of galectin-9 or, in most of the cases, do not secrete it at all. Our aims were to elucidate whether T cells can induce galectin-9 secretion in human cancer cells derived from solid malignant tumors and whether this soluble form displays higher systemic immunosuppressive activity compared with the cell surface-based protein.MethodsA wide range of human cancer cell lines derived from solid tumours, keratinocytes and primary embryonic cells were employed, together with helper and cytotoxic T cell lines and human as well as mouse primary T cells. Western blot analysis, ELISA, quantitative reverse transcriptase-PCR, on-cell Western and other measurement techniques were used to conduct the study. Results were validated using in vivo mouse model.ResultsWe discovered that T lymphocytes induce galectin-9 secretion in various types of human cancer cells derived from solid malignant tumors. This was demonstrated to occurviatwo differential mechanisms: first by translocation of galectin-9 onto the cell surface followed by its proteolytic shedding and second due to autophagy followed by lysosomal secretion. For both mechanisms a protein carrier/trafficker was required, since galectin-9 lacks a secretion sequence. Secreted galectin-9 pre-opsonised T cells and, following interaction with other immune checkpoint proteins, their activity was completely attenuated. As an example, we studied the cooperation of galectin-9 and V-domain Ig-containing suppressor of T cell activation (VISTA) proteins in human cancer cells.ConclusionOur results underline a crucial role of galectin-9 in anticancer immune evasion. As such, galectin-9 and regulatory pathways controlling its production should be considered as key targets for immunotherapy in a large number of cancers.
JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation
Authors: Nyirenda Mukanthu H , Nijjar Jagtar Singh , Frleta-Gilchrist Marina , Gilchrist Derek S , Porter Duncan , Siebert Stefan , Goodyear Carl S , McInnes Iain B 
Published: January 2023

ObjectivesMacrophage subsets, activated by T cells, are increasingly recognised to play a central role in rheumatoid arthritis (RA) pathogenesis. Janus kinase (JAK) inhibitors have proven beneficial clinical effects in RA. In this study, we investigated the effect of JAK inhibitors on the generation of cytokine-activated T (Tck) cells and the production of cytokines and chemokines induced by Tck cell/macrophage interactions.MethodsCD14+monocytes and CD4+T cells were purified from peripheral blood mononuclear cells from buffy coats of healthy donors. As representative JAK inhibitors, tofacitinib or ruxolitinib were added during Tck cell differentiation. Previously validated protocols were used to generate macrophages and Tck cells from monocytes and CD4+T cells, respectively. Cytokine and chemokine including TNF, IL-6, IL-15, IL-RA, IL-10, MIP1α, MIP1β and IP10 were measured by ELISA.ResultsJAK inhibitors prevented cytokine-induced maturation of Tck cells and decreased the production of proinflammatory cytokines TNF, IL-6, IL-15, IL-1RA and the chemokines IL-10, MIP1α, MIP1β, IP10 by Tck cell-activated macrophages in vitro (p<0.05).ConclusionsOur findings show that JAK inhibition disrupts T cell-induced macrophage activation and reduces downstream proinflammatory cytokine and chemokine responses, suggesting that suppressing the T cell-macrophage interaction contributes to the therapeutic effect of JAK inhibitors.
Abstract IA011: Implementation of population-based precision cancer screening programs
Authors: Pashayan Nora 
Published: January 2023

Abstract
To date, evidence from modeling studies indicates that precision early detection approaches could potentially improve the benefit-harm balance and the cost-effectiveness of cancer screening programs. A precision program involves risk assessment of all individuals in the population, stratification of the population into several risk groups and tailoring early detection and prevention recommendations to each risk group. Implementing precision program raises number of questions at each stage. It is important not only to generate evidence on the individual ‘jigsaw’ pieces of the program, but also to bring the pieces together in a complex adaptive system, while considering the healthcare organizational readiness for change, the economic and social context.
Citation Format: Nora Pashayan. Implementation of population-based precision cancer screening programs. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA011.
Abstract IA020: Early cancer detection through the analyses of extracellular vesicles
Authors: Lee Hakho , Castro Cesar M. 
Published: January 2023

Abstract
Breakthroughs in deep molecular profiling of non-invasive clinical samples (“liquid biopsy”) promise to revolutionize how cancer is detected and monitored. Analyzing circulating biomarkers in patient blood has shown their diagnostic potential in advanced disease states. Early detection, however, remains challenging – most biomarkers either (i) arise in advanced disease and at low abundance or (ii) often suffer from poor specificity, thus creating false positives that are costly and stressful for patients. We have been exploring extracellular vesicles (EVs) as a new biomarker that may overcome these challenges. EVs are nanoscale membrane particles secreted by cells. Most types of cancer shed large numbers of EVs that carry molecular cargo from the parent tumor. Analyzing EVs thus can represent a new real-time window to detect, diagnose, and serially monitor tumor molecular status. This presentation will describe our recent advances that leverage EVs for early cancer detection. Specifically, we will discuss the single EV analysis (SEA) platform that characterizes individual EVs for multiple protein markers. This method helps us unveil EV heterogeneity, which maximizes biological information content (specificity and sensitivity) for tumor-derived vesicles. We will review the SEA’s development and pilot application to diagnose early cancers.
Citation Format: Hakho Lee, Cesar M. Castro. Early cancer detection through the analyses of extracellular vesicles. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA020.