bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Bone Volume by Ixazomib in Multiple Myeloma: 3-Month Results from an Open Label Phase 2 Study
Authors: Diaz-delCastillo Marta , Gundesen Michael Tveden , Andersen Christian Walther , Nielsen Anne Lerberg , Møller Hanne Elisabeth Højsgaard , Vinholt Pernille Just , Asmussen Jon Thor , Kristensen Ida Bruun , Nyvold Charlotte Guldborg , Abildgaard Niels , Levin Andersen Thomas , Lund Thomas 
Published: March 2023

ABSTRACT
Multiple myeloma (MM) is an incurable bone marrow cancer characterized by the development of osteolytic lesions due to the myeloma-induced increase in osteoclastogenesis and decrease in osteoblastic activity. The standard treatment of MM often involves proteasome inhibitors (PIs), which can also have a beneficial off-target bone anabolic effect. However, long-term treatment with PIs is unadvised due to their high side-effect burden and inconvenient route of administration. Ixazomib is a new-generation, oral PI that is generally well tolerated; however, its bone effect remains unknown. Here, we describe the 3-month results of a single-center phase II clinical trial investigating the effect of ixazomib treatment on bone formation and bone microstructure. Thirty patients with MM in stable disease not receiving antimyeloma treatment for ≥3 months and presenting ≥2 osteolytic lesions received monthly ixazomib treatment cycles. Serum and plasma samples were collected at baseline and monthly thereafter. Sodium 18F-Fluoride positron emission tomography (NaF-PET) whole-body scans and trephine iliac crest bone biopsies were collected before and after three treatment cycles. The serum levels of bone remodeling biomarkers suggested an early ixazomib-induced decrease in bone resorption. NaF-PET scans indicated unchanged bone formation ratios; however, histological analyses of bone biopsies revealed a significant increase in bone volume per total volume after treatment. Further analyses of bone biopsies showed unchanged osteoclast number and COLL1A1High-expressing osteoblasts on bone surfaces. Next, we analyzed the superficial bone structural units (BSUs), which represent each recent microscopic bone remodeling event. Osteopontin staining revealed that following treatment, significantly more BSUs were enlarged (&gt;200,000 μm2), and the distribution frequency of their shape was significantly different from baseline. Overall, our data suggest that ixazomib induces overflow remodeling-based bone formation by decreasing the level of bone resorption and promoting longer bone formation events, making it a potentially valuable candidate for future maintenance treatment. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Experiential techniques and therapeutic relationship in the treatment of narcissistic personality disorder: The case of Laura
Authors: Centonze Antonella , Popolo Raffaele , Panagou Corinna , MacBeth Angus , Dimaggio Giancarlo 
Published: March 2023

AbstractExperiential techniques can be used to address maladaptive interpersonal patterns in patients with personality disorders (PDs) as long as they are delivered minding about the therapeutic relationship. We present the case study of Laura, a 38‐year‐old woman presenting with covert narcissism, generalized anxiety disorder, depression, and complicated grief treated with metacognitive interpersonal therapy. Laura initially refused to engage in any experiential work out of fear of being judged and abandoned by her therapist. To navigate this therapeutic obstacle, the therapist focused on exploring and eventually repairing early alliance ruptures. Thereafter, Laura engaged in experiential work, which helped her address her narcissistic interpersonal patterns. After 2 years, Laura's symptoms and narcissistic problematic behaviors decreased. This case study can help us understand how experiential techniques can be successfully used in PD psychotherapy as long as attention to the therapy relationship is paid.
Understanding community‐ and system‐capacity change over time: A close look at changing social capital in Evidence2Success communities
Authors: Chilenski Sarah M. , Gayles Jochebed , Luneke Aaron , Lew Daphne , Villarruel Francisco , Penilla Mary Lisa , Henderson Charles , Wilson Hilder , Gary Lisa 
Published: March 2023

AbstractEvidence in majority White and low‐population areas suggest that community prevention systems can create social capital that is needed to support high‐quality implementation and sustainability of evidence‐based programs. This study expands prior work by asking the question: How does community social capital change during the implementation of a community prevention system in low‐income, highly populated communities of color? Data were collected from Community Board members and Key Leaders in five communities. Linear mixed effect models analyzed data on reports of social capital over time, first as reported by Community Board members then by Key Leaders. Community Board members reported social capital improved significantly over time during the implementation of the Evidence2Success framework. Key Leader reports did not change significantly over time. These findings suggest that community prevention systems implemented in historically marginalized communities may help communities build social capital that is likely to support the dissemination and sustainability of evidence‐based programs.
Ballast water treatment by ozone nanobubbles
Authors: Seridou Petroula , Kotzia Eleftheria , Katris Konstantinos , Kalogerakis Nicolas 
Published: March 2023

AbstractBACKGROUNDThe uncontrolled discharge of untreated ballast water, which is essential for a ship's optimal operation, is one of the major causes of sea environmental pollution by shipping. Among the disinfection methods available for ballast water treatment, ozonation is a commonly used method, but its performance is limited by the rapid ozone auto‐decomposition rate. Nanobubbles (NBs) technology has attracted much scientific interest as it is characterized by a long residence time in the aqueous phase and a high surface area; therefore, ozone nanobubbles (OzNBs) are expected to enhance disinfection capacity and residual activity. The present study was designed to provide further insight into the inactivation of heterotrophic bacteria in saline water and to examine the use of OzNBs for disinfection of saline water.RESULTSThe survival rate of Escherichia coli (E. coli), which was used as indicator microorganism, along with the ozone consumption at different salinities (1.5, 4, 8 and 15 PSU) and bacterial concentrations (107, 106, and 105 CFU mL−1) with and without supplementation of OzNBs were investigated. The results indicated a statistical difference in the residual concentration of total residual oxidants (TRO) with the presence of OzNBs at salinity level 1.5 PSU and at 4 PSU only at the lowest bacterial content. At a low salinity and high bacterial concentration, the concentration of TRO was 6‐fold higher in the presence of OzNBs.CONCLUSIONThe salinity of water has a strong impact on the residual concentration of ozone. When salinity is increased, ozone reacts more rapidly with the bromide and chloride ions. The use of OzNBs exhibited a greater disinfection performance and higher residual activity. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Clinical features of the first attack with leukodystrophy‐like phenotype in children with myelin oligodendrocyte glycoprotein antibody‐associated disorders
Authors: Jiang Yan , Tan Chengbing , Li Xiujuan , Jiang Li , Hong Siqi , Yuan Ping , Zheng Heling , Fan Xiao , Han Wei 
Published: March 2023

AbstractBackgroundMyelin oligodendrocyte glycoprotein antibody‐associated disorders (MOGAD) is identified autoimmune disorder with a predominance in paediatric patients, and the disease spectrum has expanded with clinical and radiological patterns. The aim of the study was to describe the clinical characteristics of the first attack with leukodystrophy‐like phenotype with MOGAD in children.MethodsPatients hospitalized at the Children's Hospital of Chongqing Medical University from June 2017 to October 2021 with positive MOG antibodies and phenotype of leukodystrophy‐like (symmetric white matter lesions) were retrospectively analyzed. Cell‐based assays (CBAs) were used to test MOG antibodies.ResultsFour cases from 143 MOGAD patients were recruited, with two females and two males. The age of onset is all under 6 years old. At the last follow‐up, four cases exhibited a monophasic course, including ADEM in three patients and encephalitis in one patient. The mean EDSS score at onset was 4.62 ± 2.93, and the modified Rankin score (mRS) was 3.00 ± 1.82. First‐attack symptoms include fever, headache, vomiting, seizure, loss of consciousness, emotional and behavioural disorder, and ataxia. The brain MRI showed prominent extensive and essentially symmetric distribution lesions in the white matter. All patients showed clinical and partial radiological improvement after intravenous immunoglobulin and/or glucocorticoid treatment.ConclusionThe first attack with MOGAD onset of leukodystrophy‐like phenotype was more frequently seen in younger children than other phenotype patients. The patients may show impressive neurologic disorders, but most patients who receive immunotherapy have a good prognosis.
Acute metabolic responses of two marine brachyuran crabs to dilute seawater: The aerobic cost of hyper regulation
Authors: Rios Leonardo P. , Freire Carolina A. 
Published: March 2023

AbstractHepatus pudibundus(“flecked box crab”) is a stenohaline osmoconfomer, and restricted to marine habitats.Callinectes danae(“swimming crab Dana”) lives in coastal/estuarine waters and is a weak hyper regulator. There is no consensus on which strategy is more expensive metabolically face salinity challenges: conformation with higher dependence on cell volume regulation, or hyper regulation, alleviating the need for intense cell volume regulation. Crabs were probed for their acute response to dilute seawater through exposures to salinities 35‰, 30‰, 25‰, and 20‰ for 2, 4, and 6 h. Hemolymph osmolality, lactate, and ions (chloride, sodium, magnesium, potassium) were assayed, as well as muscle water content. Water dissolved oxygen, ammonia, and pH levels were also measured.H. pudibundusconformed for osmolality and displayed increase in muscle hydration along the decrease in salinity down to 25‰, whileC. danaeefficiently maintained hemolymph osmo ionic stability, consumed more oxygen, acidified more the water, and released more ammonia. In 25‰, both species spent energy:H. pudibundusputatively controlling cell volume, andC. danaeregulating hemolymph concentrations. In 20‰,H. pudibundusclosed itself, avoiding the contact of the interface epithelia with the external environment and producing much lactate, whereasC. danaespent more energy (aerobic) in extracellular osmo ionic stability. Under these conditions, anisosmotic extracellular regulation (together with additional cell volume regulation) is more oxygen consuming than osmoconformation with a putatively more intense challenge to cell volume. The exposure to hyposalinity limits the occupation of estuarine environments byH. pudibundusin short and middle term.
The negative handmade effect: How and why control deprivation thwarts desire for handmade products
Authors: Song Jiaqi (Flora) , He Dongjin , Jiang Yuwei 
Published: March 2023

AbstractThis research examines consumer reactions to handcrafted products under control deprivation. Four studies reveal that while a positive handmade effect exists among consumers whose sense of personal control is not threatened, a negative handmade effect appears for those consumers under control deprivation. That is, consumers show less favorable attitudes toward handcrafted products when their sense of personal control is threatened. This effect appears because the lower psychological ownership of handcrafted (vs. regular) products cannot instrumentally help restore consumers' sense of personal control. The negative handmade effect under control deprivation is mitigated when consumers can customize the product based on their own preferences. The current research is among the first to show how the handcrafted nature of products can backfire and lead to negative reactions among consumers (i.e., a negative handmade effect). Our findings also shed light on the antecedents and consequences of psychological product ownership and add to the current knowledge of personal control in the consumption domain.
Forage Fish Species Prefer Habitat within Designated Offshore Wind Energy Areas in the U.S. Northeast Shelf Ecosystem
Authors: Friedland Kevin D. , Adams Evan M. , Goetsch Chandra , Gulka Julia , Brady Damian C. , Rzeszowski Everett , Crear Daniel P. , Gaichas Sarah , Gill Andrew B. , McManus M. Conor , Methratta Elizabeth T. , Morano Janelle L. , Staudinger Michelle D. 
Published: March 2023

Abstract
As the world develops sources of renewable energy, there is an intensifying interest in offshore wind energy production. The Northeast U.S. Continental Shelf (NES) ecosystem has favorable wind dynamics, with active development of wind energy. In this study, we present species distribution models that consider both occupancy and biomass responses for a broad spectrum of fish and macroinvertebrate taxa (n = 177). Building upon prior analyses, habitat was differentiated into overall and core habitats based on statistical distributions of habitat scores. Overall habitat was used to show each species' regional distribution based on fishery-independent survey captures between 1976 and 2019, whereas core habitat represented where the focus of the species' abundance was located as a subset of overall habitat. Wind energy developments may modify the water column in ways that impact lower-trophic-level productivity; therefore, added attention was given to the response of forage species. Over 20% of species showed preferential use of putative and potential wind development areas, including a disproportionate number of forage taxa. Principal usage varied by season, with forage species like Atlantic Menhaden Brevoortia tyrannus and Atlantic Mackerel Scomber scombrus preferentially using the lease areas in spring and Round Herring Etrumeus teres and longfin inshore squid Doryteuthis pealeii using lease areas in autumn. For species with relatively low usage of the lease areas, there was a tendency for the usage related to overall habitat to be lower than usage for core habitat; in contrast, for species with high usage of the lease areas, that usage was higher for overall habitat than for core habitat. The area of habitat tended to have positive trends across species, with these positive trends being disproportionately higher among forage taxa. These results frame the importance of wind lease areas for species in the NES, particularly forage taxa that fulfill many important ecological functions.
Beyond biogeographic patterns: Processes shaping the microbial landscape in soils and sediments along the Yangtze River
Authors: Wan Wenjie , Gadd Geoffrey M. , Gu Ji‐Dong , Liu Wenzhi , Chen Peng , Zhang Quanfa , Yang Yuyi 
Published: March 2023

AbstractDeciphering biogeographic patterns of microorganisms is important for evaluating the maintenance of microbial diversity with respect to the ecosystem functions they drives. However, ecological processes shaping distribution patterns of microorganisms across large spatial‐scale watersheds remain largely unknown. Using Illumina sequencing and multiple statistical methods, we characterized distribution patterns and maintenance diversity of microorganisms (i.e., archaea, bacteria, and fungi) in soils and sediments along the Yangtze River. Distinct microbial distribution patterns were found between soils and sediments, and microbial community similarity significantly decreased with increasing geographical distance. Physicochemical properties showed a larger effect on microbial community composition than geospatial and climatic factors. Archaea and fungi displayed stronger species replacements and weaker environmental constraints in soils than that in sediments, but opposite for bacteria. Archaea, bacteria, and fungi in soils showed broader environmental breadths and stronger phylogenetic signals compared to those in sediments, suggesting stronger environmental adaptation. Stochasticity dominated community assemblies of archaea and fungi in soils and sediments, whereas determinism dominated bacterial community assembly. Our results have therefore highlighted distinct microbial distribution patterns and diversity maintenance mechanisms between soils and sediments, and emphasized important roles of species replacement, environmental adaptability, and ecological assembly processes on microbial landscape. Our findings are helpful in predicting loss of microbial diversity in the Yangtze River Basin, and might assist the establishment of environmental policies for protecting fragile watersheds.
Agricultural contribution with respect to water challenges
Authors: Cardenas Alejandra G. 
Published: March 2023

AbstractAs our population continues to grow, the demand of a more efficient agriculture system heightens. We work to produce the highest yield possible to cover demands. Are we compromising our water quality for mass food production? In past years, the West Coast growers had been facing increasing struggles to farm with their allotted water often turning to groundwater use. California had to adopt measurements to regulate groundwater usage to protect the environment. The East Coast rain on the other hand faces with increasing amounts of algal blooms product of agricultural runoff derived from the consistent amount of rain received in that part of the country. Different approaches are being used to help reduce agricultural runoff like studies maintaining increased microbial activity in the soil to increase phosphorus uptake and preventing it from reaching waterways. California has passed the Sustainable Groundwater Management Act as an effort to encourage more conscious planning of water available.
Fabrication of wafer‐level double‐sided microlens array using injection compression molding
Authors: Cheng Ting‐Yu , Ke Kun‐Cheng , Yang Sen‐Yeu 
Published: March 2023

AbstractDouble‐sided microlens arrays (MLAs) are the key optical components of the optical component. To enhance microlens fabrication productivity, a wafer‐level, double‐sided MLA was designed and fabricated using injection compression molding (ICM). First, the Moldex3D simulation analysis results show that the design of the disc mold saves material and representation time than the multi‐cavity mold. The 4‐inch disc mold with a 4 × 4 double‐sided MLA of two inserts was used to do the study. The L9 orthogonal Taguchi method was employed to find the best combination of molding parameters. For molding experiments, 2 mold inserts with 4 × 4 convex and concave lens arrays were machined by the ultraprecision diamond turning. They were mounted into molds in one of two locations, either close to the gate or far from the gate. The molding experiment results confirmed that the ICM‐molded MLA was better than the injection molding (IM)‐molded one, with higher precision and lower residual stress. The results were similar to the simulations. The ICM molded MLA has a focal length of 2.549 mm and a spot size of 50 μm and the total deviation percentage is less than 1%. This study proves the feasibility of fabricating a wafer‐level, double‐sided MLA disc using ICM.
Prediction of gastric pH‐mediated drug exposure using physiologically‐based pharmacokinetic modeling: A case study of itraconazole
Authors: Yang Eunsol , Yu Kyung‐Sang , Lee SeungHwan 
Published: March 2023

AbstractAbnormal gastric acidity, including achlorhydria, can act as a significant source of variability in orally administered drugs especially with pH‐sensitive solubility profiles, such as weak bases, potentially resulting in an undesirable therapeutic response. This study aimed to evaluate the utility of physiologically‐based pharmacokinetic (PBPK) modeling in the prediction of gastric pH‐mediated drug exposure by using itraconazole, a weak base, as a case. An itraconazole PBPK model was developed on the mechanistic basis of its absorption kinetics in a middle‐out manner from a stepwise in vitro‐in vivo extrapolation to in vivo refinement. Afterward, an independent prospective clinical study evaluating gastric pH and itraconazole pharmacokinetics (PKs) under normal gastric acidity and esomeprazole‐induced gastric hypoacidity was conducted for model validation. Validation was performed by comparing the predicted data with the clinical observations, and the valid model was subsequently applied to predict PK changes under achlorhydria. The developed itraconazole PBPK model showed reasonable reproducibility for gastric pH‐mediated exposure observed in the clinical investigation. Based on the model‐based simulations, itraconazole exposure was expected to be decreased up to 65% under achlorhydria, and furthermore, gastric pH‐mediated exposure could be mechanistically interpreted according to sequential variation in total solubility, dissolution, and absorption. This study suggested the utility of PBPK modeling in the prediction of gastric pH‐mediated exposure, especially for drugs whose absorption is susceptible to gastric pH. Our findings will serve as a leading model for further mechanistic assessment of exposure depending on gastric pH for various drugs, ultimately contributing to personalized pharmacotherapy.
Quantification of follow‐up time in oncology clinical trials with a time‐to‐event endpoint: Asking the right questions
Authors: Rufibach Kaspar , Grinsted Lynda , Li Jiang , Weber Hans Jochen , Zheng Cheng , Zhou Jiangxiu 
Published: March 2023

AbstractFor the analysis of a time‐to‐event endpoint in a single‐arm or randomized clinical trial it is generally perceived that interpretation of a given estimate of the survival function, or the comparison between two groups, hinges on some quantification of the amount of follow‐up. Typically, a median of some loosely defined quantity is reported. However, whatever median is reported, is typically not answering the question(s) trialists actually have in terms of follow‐up quantification. In this paper, inspired by the estimand framework, we formulate a comprehensive list of relevant scientific questions that trialists have when reporting time‐to‐event data. We illustrate how these questions should be answered, and that reference to an unclearly defined follow‐up quantity is not needed at all. In drug development, key decisions are made based on randomized controlled trials, and we therefore also discuss relevant scientific questions not only when looking at a time‐to‐event endpoint in one group, but also for comparisons. We find that different thinking about some of the relevant scientific questions around follow‐up is required depending on whether a proportional hazards assumption can be made or other patterns of survival functions are anticipated, for example, delayed separation, crossing survival functions, or the potential for cure. We conclude the paper with practical recommendations.