bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cingulate dynamics track depression recovery with deep brain stimulation
Authors: Alagapan Sankaraleengam , Choi Ki Sueng , Heisig Stephen , Riva-Posse Patricio , Crowell Andrea , Tiruvadi Vineet , Obatusin Mosadoluwa , Veerakumar Ashan , Waters Allison C. , Gross Robert E. , Quinn Sinead , Denison Lydia , O’Shaughnessy Matthew , Connor Marissa , Canal Gregory , Cha Jungho , Hershenberg Rachel , Nauvel Tanya , Isbaine Faical , Afzal Muhammad Furqan , Figee Martijn , Kopell Brian H. , Butera Robert , Mayberg Helen S. , Rozell Christopher J. 
Published: September 2023

AbstractDeep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD)1. However, achieving stable recovery is unpredictable2, typically requiring trial-and-error stimulation adjustments due to individual recovery trajectories and subjective symptom reporting3. We currently lack objective brain-based biomarkers to guide clinical decisions by distinguishing natural transient mood fluctuations from situations requiring intervention. To address this gap, we used a new device enabling electrophysiology recording to deliver SCC DBS to ten TRD participants (ClinicalTrials.gov identifier NCT01984710). At the study endpoint of 24 weeks, 90% of participants demonstrated robust clinical response, and 70% achieved remission. Using SCC local field potentials available from six participants, we deployed an explainable artificial intelligence approach to identify SCC local field potential changes indicating the patient’s current clinical state. This biomarker is distinct from transient stimulation effects, sensitive to therapeutic adjustments and accurate at capturing individual recovery states. Variable recovery trajectories are predicted by the degree of preoperative damage to the structural integrity and functional connectivity within the targeted white matter treatment network, and are matched by objective facial expression changes detected using data-driven video analysis. Our results demonstrate the utility of objective biomarkers in the management of personalized SCC DBS and provide new insight into the relationship between multifaceted (functional, anatomical and behavioural) features of TRD pathology, motivating further research into causes of variability in depression treatment.
The first high-quality genome assembly and annotation of Patiria pectinifera
Authors: Jung Jaehoon , Jhang So Yun , Kim Bongsang , Koh Bomin , Ban Chaeyoung , Seo Hyojung , Park Taeseo , Chi Won-Jae , Kim Soonok , Kim Heebal , Yu Jaewoong 
Published: September 2023

AbstractThe blue bat star, a highly adaptive species in the East Sea of Korea, has displayed remarkable success in adapting to recent climate change. The genetic mechanisms behind this success were not well-understood, prompting our report on the first chromosome-level assembly of the Patiria genus. We assembled the genome using Nanopore and Illumina sequences, yielding a total length of 615 Mb and a scaffold N50 of 24,204,423 bp. Hi-C analysis allowed us to anchor the scaffold sequences onto 22 pseudochromosomes. K-mer based analysis revealed 5.16% heterozygosity rate of the genome, higher than any previously reported echinoderm species. Our transposable element analysis exposed a substantial number of genome-wide retrotransposons and DNA transposons. These results offer valuable resources for understanding the evolutionary mechanisms behind P. pectinifera’s successful adaptation in fluctuating environments.
A solar panel dataset of very high resolution satellite imagery to support the Sustainable Development Goals
Authors: Clark Cecilia N. , Pacifici Fabio 
Published: September 2023

AbstractEffectively supporting the United Nations’ Sustainable Development Goals requires reliable, substantial, and timely data. For solar panel installation monitoring, where accurate reporting is crucial in tracking green energy production and sustainable energy access, official and regulated documentation remains inconsistent. Reports of solar panel installations have been supplemented with object detection models developed and used on openly available aerial imagery, a type of imagery collected by aircraft or drones and limited by cost, extent, and geographic location. We address these limitations by providing a solar panel dataset derived from 31 cm resolution satellite imagery to support rapid and accurate detection at regional and international scales. We also include complementary satellite imagery at 15.5 cm resolution with the aim of further improving solar panel detection accuracy. The dataset of 2,542 annotated solar panels may be used independently to develop detection models uniquely applicable to satellite imagery or in conjunction with existing solar panel aerial imagery datasets to support generalized detection models.
Single-nucleus transcriptomic mapping of blast-induced traumatic brain injury in mice hippocampus
Authors: Zhang Lingxuan , Yang Qiuyun , Yuan Ruixuan , Li Manrui , Lv Meili , Zhang Lin , Xie Xiaoqi , Liang Weibo , Chen Xiameng 
Published: September 2023

AbstractAs a significant type of traumatic brain injury (TBI), blast-induced traumatic brain injury (bTBI) frequently results in severe neurological and psychological impairments. Due to its unique mechanistic and clinical features, bTBI presents diagnostic and therapeutic challenges compared to other TBI forms. The hippocampus, an important site for secondary injury of bTBI, serves as a key niche for neural regeneration and repair post-injury, and is closely associated with the neurological outcomes of bTBI patients. Nonetheless, the pathophysiological alterations of hippocampus underpinning bTBI remain enigmatic, and a corresponding transcriptomic dataset for research reference is yet to be established. In this investigation, the single-nucleus RNA sequencing (snRNA-seq) technique was employed to sequence individual hippocampal nuclei of mice from bTBI and sham group. Upon stringent quality control, gene expression data from 17,278 nuclei were obtained, with the dataset’s reliability substantiated through various analytical methods. This dataset holds considerable potential for exploring secondary hippocampal injury and neurogenesis mechanisms following bTBI, with important reference value for the identification of specific diagnostic and therapeutic targets for bTBI.
Effects of pesticide-adjuvant combinations used in almond orchards on olfactory responses to social signals in honey bees (Apis mellifera)
Authors: Wu Wen-Yen , Liao Ling-Hsiu , Lin Chia-Hua , Johnson Reed M. , Berenbaum May R. 
Published: September 2023

AbstractExposure to agrochemical sprays containing pesticides and tank-mix adjuvants has been implicated in post-bloom mortality, particularly of brood, in honey bee colonies brought into California almond orchards for pollination. Although adjuvants are generally considered to be biologically inert, some adjuvants have exhibited toxicity and sublethal effects, including decreasing survival rates of next-generation queens. Honey bees have a highly developed olfactory system to detect and discriminate among social signals. To investigate the impact of pesticide-adjuvant combinations on honey bee signal perception, we performed electroantennography assays to assess alterations in their olfactory responsiveness to the brood ester pheromone (BEP), the volatile larval pheromone β-ocimene, and the alarm pheromone 2-heptanone. These assays aimed to uncover potential mechanisms underlying changes in social behaviors and reduced brood survival after pesticide exposure. We found that combining the adjuvant Dyne-Amic with the fungicide Tilt (propiconazole) and the insecticide Altacor (chlorantraniliprole) synergistically enhanced olfactory responses to three concentrations of BEP and as well exerted dampening and compensatory effects on responses to 2-heptanone and β-ocimene, respectively. In contrast, exposure to adjuvant alone or the combination of fungicide and insecticide had no effect on olfactory responses to BEP at most concentrations but altered responses to β-ocimene and 2-heptanone. Exposure to Dyne-Amic, Altacor, and Tilt increased BEP signal amplitude, indicating potential changes in olfactory receptor sensitivity or sensilla permeability to odorants. Given that, in a previous study, next-generation queens raised by nurses exposed to the same treated pollen experienced reduced survival, these new findings highlight the potential disruption of social signaling in honey bees and its implications for colony reproductive success.
Risk of endocarditis among patients with coagulase-negative Staphylococcus bacteremia
Authors: Ramos-Martínez Antonio , González-Merino Patricia , Suanzes-Martín Elena , la Fuente Marta Murga-de , Escudero-López Gabriela , Andrés-Eisenhofer Ane , Expósito-Palomo Esther , Gutierrez-Villanueva Andrea , Diego-Yagüe Itziar , Múñez Elena , Fernandez-Cruz Ana , Calderón-Parra Jorge 
Published: September 2023

AbstractCoagulase-negative staphylococci (CoNS) are currently considered typical microorganisms causing infective endocarditis (IE) in patients with prosthetic valves. The objective was to determine variables associated with IE in patients with CoNS bacteremia. We performed an analysis of the clinical characteristics of patients with CoNS bacteremia admitted to a university hospital in Madrid (Spain) from 2021 to December 2022 according to the occurrence of IE. This study is an evaluation of a bacteremia registry. During the study period, 106 patients with CoNS bacteremia were detected. In 85 patients an echocardiogram was performed during hospital admission to rule out IE. Among them, 12 episodes were detected that met IE criteria (14.2%). Of the 6 patients with heart valve prostheses, 5 patients (83.3%) had IE (p < 0.001). Patients with IE more frequently had positive blood cultures more than 12 h after the first draw (58.3% versus 13.4%; p < 0.001). There was a tendency to associate community-acquired bacteremia and to that all blood culture bottles obtained were positive with an increased risk of IE (p = 0.091 and p = 0,057, respectively). Attributable mortality to infection was higher in patients with IE relative to all other patients (16.7% vs. 0%; p = 0.033). The multivariable analysis included having valve prosthesis and persistent bacteremia for more than 12 h. Both were independently associated with IE: valve prosthesis OR 38.6 (95% CI 5.8–258; p < 0.001) and persistent bacteremia OR 2.6 (95% CI 1.1–6.8; p = 0.046). In conclusion, a high percentage of cases of CoNS bacteremia may be due to IE. Some of the variables related to a higher risk of IE, such as having a valvular prosthesis or presenting positive blood cultures for more than 12 h, should lead to rule out or confirm the presence of IE by performing echocardiography.
Different estimation techniques for constant-partially accelerated life tests of chen distribution using complete data
Authors: Radwan H. M. M. , Alenazi Abdulaziz 
Published: September 2023

AbstractThe issue of various estimation techniques in constant partially accelerated life tests with complete data is the main subject of this research. The Chen distribution is regarded as an item’s lifetime under use conditions. To estimate the distribution parameters and the acceleration factor, maximum likelihood estimation, least square estimation, weighted least square estimation, Cramér Von–Mises estimation, Anderson–Darling estimation, right-tail Anderson–Darling estimation, percentile estimation, and maximum product of spacing estimation are presented for classical estimation. For illustrative purposes, two real data sets are analyzed. The investigation of the two real data sets reveals that the suggested techniques are practical and can be used to solve some engineering-related issues. In order to compare the results of the several estimation techniques that have been offered based on mean square error and absolute average bias, a simulation study is presented at the end. When adopting the smallest values for mean square error and absolute average bias, this study demonstrates that maximum product of spacing estimation is the technique that is most effective among the alternatives in most cases.
RANet: a custom CNN model and quanvolutional neural network for the automated detection of rheumatoid arthritis in hand thermal images
Authors: Ahalya R. K. , Almutairi Fadiyah M. , Snekhalatha U. , Dhanraj Varun , Aslam Shabnam M. 
Published: September 2023

AbstractRheumatoid arthritis is an autoimmune disease which affects the small joints. Early prediction of RA is necessary for the treatment and management of the disease. The current work presents a deep learning and quantum computing-based automated diagnostic approach for RA in hand thermal imaging. The study’s goals are (i) to develop a custom RANet model and compare its performance with the pretrained models and quanvolutional neural network (QNN) to distinguish between the healthy subjects and RA patients, (ii) To validate the performance of the custom model using feature selection method and classification using machine learning (ML) classifiers. The present study developed a custom RANet model and employed pre-trained models such as ResNet101V2, InceptionResNetV2, and DenseNet201 to classify the RA patients and normal subjects. The deep features extracted from the RA Net model are fed into the ML classifiers after the feature selection process. The RANet model, RA Net+ SVM, and QNN model produced an accuracy of 95%, 97% and 93.33% respectively in the classification of healthy groups and RA patients. The developed RANet and QNN models based on thermal imaging could be employed as an accurate automated diagnostic tool to differentiate between the RA and control groups.
A flexible wearable self-supporting hybrid supercapacitor device based on hierarchical nickel cobalt sulfide@C electrode
Authors: Chen Xin , Sun Ming , Jaber Fadi , Nezhad Erfan Zal , Hui K. S. , Li Zhenwu , Bae Sungchul , Ding Muge 
Published: September 2023

AbstractA flexible wearable electrode consisting of nickel–cobalt sulfide (NCS) nanowires was fabricated in this study. Self-supporting NCS was grown in situ on porous carbon nanofibers without a binder as a novel material for supercapacitor electrodes. The NCS nanowires were grown using cyclic voltammetry electrodeposition, which proved to be a fast and environmentally friendly method with good controllability of the material structure. One-dimensional carbon nanofibers (C) have high surface-area-to-volume ratios, short ion transmission distances, excellent mechanical strengths, and remarkable flexibilities. Moreover, the NCS@C flexible electrode exhibited a synergetic effect with the active compounds, and the dense active sites were uniformly distributed across the entire surface of the carbon fibers, enabling rapid electron transport and enhancing the electrochemical properties of the NCS@C nanowires. The NCS@C achieved specific capacitances of 334.7 and 242.0 mAh g−1 at a current density of 2 A g−1 and high current densities (up to 40 A g−1), respectively, corresponding to a 72.3% retention rate. An NCS@C-nanofilm-based cathode and an activated-carbon-based anode were used to fabricate a flexible asymmetric supercapacitor. The device exhibited high energy and power densities of 12.91 Wh kg−1 and 358 W kg−1, respectively.
Utility of standing office blood pressure in detecting hypertension in healthy adults
Authors: Giacona John M. , Kositanurit Weerapat , Wang Jijia , Petric Ursa B. , Khan Ghazi , Pittman Danielle , Williamson Jon W. , Smith Scott A. , Vongpatanasin Wanpen 
Published: September 2023

AbstractCurrent guidelines recommend office blood pressures (BP) be taken in a seated position when screening for hypertension (HTN). Seated BP is known to have limited accuracy in detecting high BP, while the utility of standing BP in diagnosing HTN is unknown. We conducted a cross-sectional study to determine the incremental value of standing BP in diagnosing HTN. Seated, standing, and 24-h ambulatory BPs (ABPM) were obtained in adults without known cardiovascular disease, HTN, or BP medication use. Presence of HTN was defined by the 2017 ACC/AHA and the 2023 ESH HTN guidelines based on ABPM. Area under the receiver-operating-characteristic curve (AUROC) was used to evaluate the diagnostic accuracy of seated and standing BP. Sensitivity and specificity of standing BP was determined using cut-offs derived from Youden’s Index, while sensitivity and specificity of seated BP was determined using the cut-off of 130/80 mmHg and by 140/90 mmHg. Among 125 participants (mean age 49 ± 17 years; 62% female; 24% Black), 33.6% of them had HTN. Sensitivity and specificity of seated systolic BP (SBP) was 43% and 92%, respectively. Cut-offs selected by Youden’s index for standing SBP/diastolic BP (DBP) were 124/81 mmHg according to the 2017 ACC/AHA HTN guidelines, and 123.5/83.5 mmHg according to the 2023 ESH HTN guidelines. Sensitivity and specificity of standing SBP was 71% and 67%, respectively. The AUROC of standing SBP (0.81 [0.71–0.92]) was significantly higher than seated SBP (0.70 [0.49–0.91]), when HTN was defined as average 24-h SBP ≥ 125 mmHg. Moreover, the addition of standing to seated SBP (0.80 [0.68–0.92]) improved HTN detection when compared to seated SBP. These patterns were consistent for both the 2017 ACC/AHA and the 2023 ESH definitions for HTN. In summary, standing BP, alone or in combination with seated BP, outperformed seated BP alone in diagnosing HTN in adults.
Evaluation of face shields used during aerosol generating procedures
Authors: Pratt Alessandra A. , Brown Grant D. , Walsh Jarrett E. , Hoffman Henry T. , Nonnenmann Matthew W. 
Published: September 2023

AbstractTransnasal flexible laryngoscopy is considered an aerosol generating procedure. A negative pressure face shield (NPFS) was developed to control aerosol from the patient during laryngoscopy. The purpose of this study was to determine the effectiveness of the NPFS at controlling virus aerosol compared to a standard disposable plastic face shield. The face shields were placed on a simulated patient coughing machine. MS2 bacteriophage was used as a surrogate for SARS-CoV-2 and was aerosolized using the coughing machine. The aerosolized virus was sampled on the inside and outside of the face shields. The virus aerosol concentration was not significantly different between the inside and outside of the traditional plastic face shield (p = 0.12). However, the particle concentrations across all particle sizes measured were significantly decreased outside the face shield. The virus and particle concentrations were significantly decreased (p < 0.01) outside the NPFS operating at a flow rate of 38.6 L per minute (LPM). When the NPFS was operated at 10 LPM, virus concentrations were not significantly different (p = 0.09) across the face shield. However, the number particle concentrations across all particle sizes measured were significantly different (p < 0.05).
Assessment of safety and intranasal neutralizing antibodies of HPMC-based human anti-SARS-CoV-2 IgG1 nasal spray in healthy volunteers
Authors: Imsuwansri Thanarath , Jongthitinon Thitinan , Pojdoung Niramon , Meesiripan Nuntana , Sakarin Siriwan , Boonkrai Chatikorn , Wongtangprasert Tossapon , Phakham Tanapati , Audomsun Thittaya , Attakitbancha Chadaporn , Saelao Pijitra , Muanwien Phijitra , Tian Maoxin Tim , Tongchusak Songsak , Sangruji Bhrus , Wannigama Dhammika Leshan , Sawangmake Chenphop , Rodprasert Watchareewan , Le Quynh Dang , Purbantoro Steven Dwi , Vasuntrarak Kananuch , Nantavisai Sirirat , Sirilak Supakit , Uppapong Ballang , Sapsutthipas Sompong , Trisiriwanich Sakalin , Somporn Thitiporn , Usoo Asmah , Mingngamsup Natthakarn , Phumiamorn Supaporn , Aumklad Porawan , Arunprasert Kwanputtha , Patrojanasophon Prasopchai , Opanasopit Praneet , Pesirikan Norapath , Nitisaporn Ladda , Pitchayakorn Jesada , Narkthong Thana , Mahong Bancha , Chaiyo Kumchol , Srisutthisamphan Kanjana , Viriyakitkosol Ratchanont , Aeumjaturapat Songklot , Jongkaewwattana Anan , Bunnag Sakarn , Pisitkun Trairak 
Published: September 2023

AbstractAn HPMC-based nasal spray solution containing human IgG1 antibodies against SARS-CoV-2 (nasal antibody spray or NAS) was developed to strengthen COVID-19 management. NAS exhibited potent broadly neutralizing activities against SARS-CoV-2 with PVNT50 values ranging from 0.0035 to 3.1997 μg/ml for the following variants of concern (ranked from lowest to highest): Alpha, Beta, Gamma, ancestral, Delta, Omicron BA.1, BA.2, BA.4/5, and BA.2.75. Biocompatibility assessment showed no potential biological risks. Intranasal NAS administration in rats showed no circulatory presence of human IgG1 anti-SARS-CoV-2 antibodies within 120 h. A double-blind, randomized, placebo-controlled trial (NCT05358873) was conducted on 36 healthy volunteers who received either NAS or a normal saline nasal spray. Safety of the thrice-daily intranasal administration for 7 days was assessed using nasal sinuscopy, adverse event recording, and self-reporting questionnaires. NAS was well tolerated, with no significant adverse effects during the 14 days of the study. The SARS-CoV-2 neutralizing antibodies were detected based on the signal inhibition percent (SIP) in nasal fluids pre- and post-administration using a SARS-CoV-2 surrogate virus neutralization test. SIP values in nasal fluids collected immediately or 6 h after NAS application were significantly increased from baseline for all three variants tested, including ancestral, Delta, and Omicron BA.2. In conclusion, NAS was safe for intranasal use in humans to increase neutralizing antibodies in nasal fluids that lasted at least 6 h.
Probing mechanical interaction of immune receptors and cytoskeleton by membrane nanotube extraction
Authors: Manca Fabio , Eich Gautier , N’Dao Omar , Normand Lucie , Sengupta Kheya , Limozin Laurent , Puech Pierre-Henri 
Published: September 2023

AbstractThe role of force application in immune cell recognition is now well established, the force being transmitted between the actin cytoskeleton to the anchoring ligands through receptors such as integrins. In this chain, the mechanics of the cytoskeleton to receptor link, though clearly crucial, remains poorly understood. To probe this link, we combine mechanical extraction of membrane tubes from T cells using optical tweezers, and fitting of the resulting force curves with a viscoelastic model taking into account the cell and relevant molecules. We solicit this link using four different antibodies against various membrane bound receptors: antiCD3 to target the T Cell Receptor (TCR) complex, antiCD45 for the long sugar CD45, and two clones of antiCD11 targeting open or closed conformation of LFA1 integrins. Upon disruption of the cytoskeleton, the stiffness of the link changes for two of the receptors, exposing the existence of a receptor to cytoskeleton link—namely TCR-complex and open LFA1, and does not change for the other two where a weaker link was expected. Our integrated approach allows us to probe, for the first time, the mechanics of the intracellular receptor–cytoskeleton link in immune cells.