bluuebunny/crossref_metadata_2025_split huggingface dataset:
Candida parapsilosis cell wall proteins—CPAR2_404800 and CPAR2_404780—Are adhesins that bind to human epithelial and endothelial cells and extracellular matrix proteins
Authors: Satala Dorota , Karkowska‐Kuleta Justyna , Bras Grazyna , Rapala‐Kozik Maria , Kozik Andrzej 
Published: March 2023

AbstractOne of the initial steps necessary for the development of Candida infections is the adherence to the host tissues and cells. Recent transcriptomic studies suggest that, in Candida parapsilosis—a fungal infectious agent that causes systemic candidiasis in immunosuppressed individuals—the adhesion is mediated by pathogen cell‐exposed proteins belonging to the agglutinin‐like sequence (Als) family. However, to date, the actual interactions of individual members of this family with human cells and extracellular matrix (ECM) have not been characterized in detail. In the current study, we focused attention on two of these C. parapsilosis Als proteins—CPAR2_404800 and CPAR2_404780—that were proteomically identified in the fungal cell wall of yeasts grown in the media suitable for culturing human epithelial and endothelial cells. Both proteins were extracted from the cell wall and purified, and using a microplate binding assay and a fluorescence microscopic analysis were shown to adhere to human cells of A431 (epithelial) and HMEC‐1 (endothelial) lines. The human extracellular matrix components that are also plasma proteins—fibronectin and vitronectin—enhanced these interactions, and also could directly bind to CPAR2_404800 and CPAR2_404780 proteins, with a high affinity (KD in a range of 10−7 to 10−8 M) as determined by surface plasmon resonance measurements. Our findings highlight the role of proteins CPAR2_404800 and CPAR2_404780 in adhesion to host cells and proteins, contributing to the knowledge of the mechanisms of host‐pathogen interactions during C. parapsilosis‐caused infections.
Meromorphic cosets and the classification of three-character CFT
Authors: Das Arpit , Gowdigere Chethan N. , Mukhi Sunil 
Published: March 2023

Abstract
We investigate the admissible vector-valued modular forms having three independent characters and vanishing Wronskian index and determine which ones correspond to genuine 2d conformal field theories. This is done by finding bilinear coset-type relations that pair them into meromorphic characters with central charges 8, 16, 24, 32 and 40. Such pairings allow us to identify some characters with definite CFTs and rule out others. As a key result we classify all unitary three-character CFT with vanishing Wronskian index, excluding c = 8, 16. The complete list has two infinite affine series Br,1, Dr,1 and 45 additional theories. As a by-product, at higher values of the total central charge we also find constraints on the existence or otherwise of meromorphic theories. We separately list several cases that potentially correspond to Intermediate Vertex Operator Algebras.
Flavor- and CP-safe explanation of gμ − 2 anomaly
Authors: Evans Jason L. , Yanagida Tsutomu T. , Yokozaki Norimi 
Published: March 2023

Abstract
Supersymmetry is still a viable explanation for the muon g – 2 anomaly, if the sleptons and electroweak gauginos are $$ \mathcal{O}(100) $$
O

100

GeV. However, for supersymmetry breaking masses this light, the SUSY flavor and CP-problem are exacerbated. To address this issue, we consider a flavor-safe gauge mediated explanation of the muon g – 2 with additional Higgs soft supersymmetry breaking mass parameters. The setup provides a generic parameter space within minimal gauge mediation. Furthermore, we show that the problematic CP violating phase can be dynamically suppressed. We find that gauge mediation models have large portions of parameter space where the muon g – 2 can be explained at 1 σ level. The interplay between the slepton and the CP-odd Higgs masses also makes the majority of this model’s parameter space testable at the LHC through searches for sleptons or additional Higgs bosons.
Topological phenomena in honeycomb Floquet metamaterials
Authors: Ammari Habib , Kosche Thea 
Published: March 2023

AbstractBeing driven by the goal of finding edge modes and of explaining the occurrence of edge modes in the case of time-modulated metamaterials in the high-contrast and subwavelength regime, we analyse the topological properties of Floquet normal forms of periodically parameterized time-periodic linear ordinary differential equations $$\left\{ \frac{d}{dt}X = A_\alpha (t)X\right\} _{\alpha \in {\mathbb {T}}^d}$$

d

dt

X
=

A
α

(
t
)

X

α
∈

T

d

. In fact, our main goal being the question whether an analogous principle as the bulk-boundary correspondence of solid-state physics is possible in the case of Floquet metamaterials, i.e., subwavelength high-contrast time-modulated metamaterials. This paper is a first step in that direction. Since the bulk-boundary correspondence states that topological properties of the bulk materials characterize the occurrence of edge modes, we dedicate this paper to the topological analysis of subwavelength solutions in Floquet metamaterials. This work should thus be considered as a basis for further investigation on whether topological properties of the bulk materials are linked to the occurrence of edge modes. The subwavelength solutions being described by a periodically parameterized time-periodic linear ordinary differential equation $$\left\{ \frac{d}{dt}X = A_\alpha (t)X\right\} _{\alpha \in {\mathbb {T}}^d}$$

d

dt

X
=

A
α

(
t
)

X

α
∈

T

d

, we put ourselves in the general setting of periodically parameterized time-periodic linear ordinary differential equations and introduce a way to (topologically) classify a Floquet normal form F, P of the associated fundamental solution $$\left\{ X_\alpha (t) = P(\alpha ,t)\exp (tF_\alpha )\right\} _{\alpha \in {\mathbb {T}}^d}$$

X
α

(
t
)

=
P

(
α
,
t
)

exp

(
t

F
α

)

α
∈

T

d

. This is achieved by analysing the topological properties of the eigenvalues and eigenvectors of the monodromy matrix $$X_\alpha (T)$$

X
α

(
T
)

and the Lyapunov transformation $$P(\alpha ,t)$$

P
(
α
,
t
)

. The corresponding topological invariants can then be applied to the setting of Floquet metamaterials. In this paper these general results are considered in the case of a hexagonal structure. We provide two interesting examples of topologically non-trivial time-modulated hexagonal structures.
Diurnal variation of cardiac autonomic activity in adolescent non-suicidal self-injury
Authors: Sigrist Christine , Jakob Hannah , Beeretz Christoph J. , Schmidt Stefanie J. , Kaess Michael , Koenig Julian 
Published: March 2023

AbstractHeart rate (HR) and vagally mediated heart rate variability (HRV) are two distinct biomarkers of cardiac autonomic activity. Decreased cardiac vagal activity (or decreased HRV) in particular has been linked with impairments in the functional flexibility of the central autonomic network (CAN), resulting in impaired stress and emotion regulatory capacities. Decreased HRV is widely used as trait marker of psychopathology. Repetitive engagement in non-suicidal self-injury (NSSI) in adolescence correlates with both deficits in stress and emotion regulation, as well as decreased HRV. Existing research has, however, focused on short-term recordings of HR and HRV under resting and phasic conditions. In this study, we examined whether diurnal variation of cardiac autonomic activity, indexed by cosinor parameters of HR and HRV derived from 48 h of ambulatory ECG recording under natural conditions over a weekend, are altered in female adolescents with NSSI disorder compared to controls (HC; N = 30 per study group). Several important confounds, including physical activity, were controlled for. Female adolescents with NSSI show higher rhythm-adjusted 24 h mean levels and greater respective amplitude of HR, as well as lower rhythm-adjusted 24 h mean levels and smaller respective amplitude of HRV. Peak levels in both HR and HRV in the NSSI group were reached approximately 1 h later compared to HC. Severity of exposure to early life maltreatment might be linked with altered amplitudes of 24 h HR and HRV. Diurnal rhythms of cardiac autonomic activity might hold promise as objective indicators of disordered stress and emotion regulation in developmental psychopathology, and as such should be investigated in future studies with rigorous assessment and control of potential confounds.
Psychological impact of COVID-19 containment on CADASIL patients
Authors: Reyes S. , Jabouley A. , Alili N. , De Sanctis M. H. , Machado C. , Taleb A. , Herve D. , Dias-Gastellier N. , Chabriat H. 
Published: March 2023

Abstract
Introduction
COVID-19 restrictive containment was responsible for major psychological distress and alteration of quality of life (QoL) in the general population. Their impact in a group of patients having cerebral small vessel disease (SVD) and at high risk of stroke and disability was unknown.

Objective
We aimed to determine the potential psychological impact of strict containment during the COVID-19 pandemic in a sample of CADASIL patients, a rare SVD caused by NOTCH3 gene mutations.

Methods
Interviews of 135 CADASIL patients were obtained just after the end of the strict containment in France. Depression, QoL and negative subjective experience of the containment were analysed, as well as predictors of posttraumatic and stressor-related manifestations, defined as an Impact Event Scale-Revised score ≥ 24, using multivariable logistic analysis.

Results
Only 9% of patients showed a depressive episode. A similar proportion had significant posttraumatic and stressor-related disorder manifestations independently associated only with socio-environment factors, rather than clinical ones: living alone outside a couple (OR 7.86 (1.87–38.32), unemployment (OR 4.73 (1.17–18.70)) and the presence of 2 or more children at home (OR 6.34 (1.35–38.34).

Conclusion
Psychological impact of the containment was limited in CADASIL patients and did not appear related to the disease status. About 9% of patients presented with significant posttraumatic and stressor-related disorder manifestations which were predicted by living alone, unemployment, or exhaustion related to parental burden.
The outcomes of a low-cost, non-valved glaucoma drainage device using mitomycin-C: 1-year results
Authors: Awad-Allah Mo’mena Ahmad A. , Mousa Amr Saleh , Ashour Doaa Maamoun 
Published: March 2023

Abstract
Purpose
To evaluate the indications, outcomes, and complications of the usage of Aurolab Aqueous Drainage Implant (AADI) using mitomycin-C.

Methods
A retrospective case series of patients who underwent AADI placement using mitomycin-C between April 2018 and June 2020 at Ain Shams University Hospitals, Cairo, Egypt. The data was extracted from the records of the patients with a minimum of 1 year of follow-up. Complete success was defined as IOP ≥ 5 mmHg and ≤ 21 mmHg or reduction of IOP by ≥ 20% from baseline without antiglaucoma medications (AGMs). Qualified success was defined as reaching the same IOP range with the aid of AGM.

Results
A total of 50 eyes of 48 patients were included. Neovascular glaucoma represented the commonest indication (13 patients, 26%). The mean preoperative IOP was 34.0 ± 7.1 mmHg, with a median number of AGM of 3 (mean ± SD = 2.84 ± 1), while the mean IOP after 12 months was 14.3 ± 4 with a median number of AGM of 0. (mean ± SD = 0.52 ± 0.89) (p < 0.001). Complete success was achieved in 33 patients (66%). Qualified success was achieved in 14 patients (28%). Thirteen eyes (26%) had variable postoperative complications; none of them required explantation of the device or affected the visual acuity (except one patient).

Conclusion
AADI with using mitomycin-C and ripcord during the surgery is an effective and relatively safe method of control of IOP in refractory and advanced cases of glaucoma, with an overall success rate of 94%.
The interplay between telomeric complex members and BCR::ABL1 oncogenic tyrosine kinase in the maintenance of telomere length in chronic myeloid leukemia
Authors: Deręgowska Anna , Pępek Monika , Solarska Iwona , Machnicki Marcin M. , Pruszczyk Katarzyna , Dudziński Marek , Niesiobędzka-Krężel Joanna , Seferyńska Ilona , Sawicki Waldemar , Wnuk Maciej , Stokłosa Tomasz 
Published: March 2023

Abstract
Purpose
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by recurrent genetic aberration in leukemic stem cells, namely Philadelphia chromosome caused by reciprocal translocation t(9;22)(q34;q11). In our study, we analyzed the telomeric complex expression and function in the molecular pathogenesis of CML.

Methods
We employed CD34+ primary leukemic cells, comprising both leukemic stem and progenitor cell populations, isolated from peripheral blood or bone marrow of CML patients in chronic and blastic phase to analyze the telomere length and telomeric-associated proteins.

Results
The reduction in telomere length during disease progression was correlated with increased expression of BCR::ABL1 transcript and the dynamic changes were neither associated with the enzymatic activity of telomerase nor with gene copy number and expression of telomerase subunits. Increased expression of BCR::ABL1 was positively correlated with expression of TRF2, RAP1, TPP1, DKC1, TNKS1, and TNKS2 genes.

Conclusions
The dynamics of telomere length changes in CD34+ CML cells is dependent on the expression level of BCR::ABL, which promotes the expression of certain shelterins including RAP1 and TRF2, as well as TNKS, and TNKS2, and results in telomere shortening regardless of telomerase activity. Our results may allow better understanding of the mechanisms responsible for the genomic instability of leukemic cells and CML progression.
An analysis of temperature anomalies in Chile using fractional integration
Authors: Gil-Alana Luis A. , Martin-Valmayor Miguel A. , Hube-Antoine Cristina 
Published: March 2023

AbstractThis paper deals with the study of stationarity and mean reversion in the temperature anomalies series in the southwestern American cone. In particular, monthly temperatures in 12 Chilean meteorological stations were studied (from the 1960’s to nowadays), examining if temperature shocks are expected to remain in the long term or if they are reversible. The results clearly show a significant relationship between the latitude, climate, and the order of integration of the temperatures. The orders of integration tend to be smaller in colder southern parts, therefore impacts of climate change are expected to be more reversible. However, in northern desert areas the orders of integration are larger than 0.5, thus impacts are expected to be maintained for a longer time.
Informing interventions to improve uptake of adjuvant endocrine therapy in women with breast cancer: a theoretical-based examination of modifiable influences on non-adherence
Authors: Cahir Caitriona , Bennett Kathleen , Dombrowski Stephan U. , Kelly Catherine M. , Wells Mary , Watson Eila , Sharp Linda 
Published: March 2023

Abstract

Purpose

To inform intervention development, we measured the modifiable determinants of endocrine therapy (ET) non-adherence in women with breast cancer, using the Theoretical Domains Framework (TDF) and examined inter-relationships between these determinants and non-adherence using the Perceptions and Practicalities Approach (PAPA).

Methods
Women with stages I–III breast cancer prescribed ET were identified from the National Cancer Registry Ireland (N = 2423) and invited to complete a questionnaire. A theoretically based model of non-adherence was developed using PAPA to examine inter-relationships between the 14 TDF domains of behaviour change and self-reported non-adherence. Structural equation modelling (SEM) was used to test the model.

Results
A total of 1606 women participated (response rate = 66%) of whom 395 (25%) were non-adherent. The final SEM with three mediating latent variables (LVs) (PAPA Perceptions: TDF domains, Beliefs about Capabilities,Beliefs about Consequences; PAPA Practicalities: TDF domain, Memory, Attention,Decision Processes and Environment) and four independent LVs (PAPA Perceptions: Illness intrusiveness; PAPA Practicalities: TDF domains, Knowledge,Behaviour Regulation; PAPA External Factors: TDF domain, Social Identity) explained 59% of the variance in non-adherence and had an acceptable fit (χ2(334) = 1002, p < 0.001; RMSEA = 0.03; CFI = 0.96 and SRMR = 0.07) Knowledge had a significant mediating effect on non-adherence through Beliefs about Consequences and Beliefs about Capabilities. Illness intrusiveness had a significant mediating effect on non-adherence through Beliefs about Consequences. Beliefsabout Consequences had a significant mediating effect on non-adherence through Memory, Attention, Decision Processesg and Environment.

Conclusions
By underpinning future interventions, this model has the potential to improve ET adherence and, hence, reduce recurrence and improve survival in breast cancer.
Combining variable neighborhood with gradient ascent for learning to rank problem
Authors: Ibrahim Osman Ali Sadek , Younis Eman M. G. 
Published: March 2023

AbstractMetaheuristic applications for information retrieval research are limited in spite of the importance of this problem domain. Ranking the retrieved documents based on their importance is a vital issue for the scientific and industrial communities. This paper proposes a novel variable neighborhood search (VNS) algorithm with adaptation based on an objective function for the learning to rank (LTR) problem. VNS is a global optimum metaheuristic algorithm that has been engaged to evolve the optimal solutions for heuristic problems based on exploring better neighbor solutions from the current one. The changes from the current to the next optimal solution are made during the perturbation stage to identify the global optimal solutions. The exploration procedure has been made through various mutation step sizes, whereas the exploitation process has been done by checking the quality of the evolved solutions using the fitness function. This research proposes a novel version of VNS based on four random probability distributions with gradient ascent. In addition to using the traditional random generator with gradient ascent for modifying the mutated genes of the neighborhood candidate solution in the following evolving iteration. This novel method in LTR is called gradient variable neighborhood (GVN). In the experiments, we utilized Microsoft Bing search (MSLR-WEB30K), Yahoo, and TREC Million Queries Competitions in 2008 and 2007 (LETOR 4) datasets. From the findings of the results, we can deduce that the GVN method outperformed recent studies on LTR methods.
Metabolic control during the first two years of the COVID-19 pandemic in pediatric patients with type 1 diabetes: results from the German DPV initiative
Authors: Hammersen Johanna , Tittel Sascha R. , Khodaverdi Semik , Reschke Felix , Flury Monika , Menzel Ulrike , Mönkemöller Kirsten , Meissner Thomas , Karges Beate , Holl Reinhard W. 
Published: March 2023

Abstract
Aim
To assess effects of the SARS-CoV2 pandemic on metabolic control in youth with type 1 diabetes (T1D) in Germany in a population-based analysis.

Methods
Data from 33,372 pediatric T1D patients from the Diabetes Prospective Follow-up (DPV) registry, with face-to-face visits or telemedicine contacts in the years 2019–2021, were available. Datasets from eight time periods between March 15, 2020, and December 31, 2021, according to SARS-CoV2 incidence waves, were compared to those from five control time periods. Parameters of metabolic control were assessed with adjustment for sex, age, diabetes duration, and repeated measurements. Laboratory-measured HbA1c values and those estimated from CGM were aggregated into a combined glucose indicator (CGI).

Results
There was no clinically relevant difference in metabolic control between pandemic and control time periods with adjusted CGI values ranging from 7.61% [7.60–7.63] (mean [95% confidence interval (CI)]) in the third quarter of 2019 to 7.83% [7.82–7.85] in the time period from January 1 to March 15 2020, in the other control periods, and during the pandemic, CGI values lay between these values. BMI-SDS rose during the pandemic from 0.29 [0.28–0.30] (mean [95% CI]) in the third quarter of 2019 to 0.40 [0.39–0.41] during the fourth wave. Adjusted insulin dose rose during the pandemic. Event rates for hypoglycemic coma and diabetic ketoacidosis remained unchanged.

Conclusions
We found no clinically relevant change of glycemic control or incidence of acute diabetes complications during the pandemic. The observed BMI increase may represent an important health risk for youth with T1D.
Electrochemistry for non-electrochemists: a postgraduate formative project
Authors: Doménech-Carbó Antonio , Martini Mariele , Di Turo Francesca , de Silveira Géssica Domingos , Montoya Noemí 
Published: March 2023

AbstractThe essential guidelines are presented of a postgraduate course on electrochemistry for master studies at the University of Valencia (Spain). This course has been designed for students with a minimal knowledge of electrochemistry. It is based on laboratory experiments that, starting from an initial theoretical core, promotes the in-laboratory discussion of concepts, operations, functional relations, etc. The course, although focused on voltammetric techniques, covers the main concepts and experimental aspects of electrochemistry and particular attention is put to erroneous conceptions regarding fundamental physicochemical concepts and operations (misconceptions) as well as on general aspects of the scientific methodology (meta-conceptions) around this discipline.
The infinite Lanczos method for symmetric nonlinear eigenvalue problems
Authors: Mele Giampaolo 
Published: March 2023

AbstractA new iterative method for solving large scale symmetric nonlinear eigenvalue problems is presented. We firstly derive an infinite dimensional symmetric linearization of the nonlinear eigenvalue problem, then we apply the indefinite Lanczos method to this specific linearization, resulting in a short-term recurrence. We show how, under specific assumption on the starting vector, this method can be carried out in finite arithmetic and how the exploitation of the problem structure leads to improvements in terms of computation time. The eigenpair approximations are extracted with the nonlinear Rayleigh-Ritz procedure combined with a specific choice of the projection space. We illustrate how this extraction technique resolves the instability issues that may occur due to the loss of orthogonality in many standard Lanczos-type methods.