bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marketing claims, promotional strategies, and product information on Malaysian e-cigarette retailer websites - a systematic content analysis
Authors: Shroff Sameeha Misriya , Sreeramare chandrashekhar T 
Published: August 2023

Abstract
Background
Marketing and sales are unregulated in Malaysia. We systematically analyzed content displayed on e-cigarette retailer websites to identify marketing claims, promotional strategies, and product details.
Methods
We analyzed 30 Malaysia-based retailer websites. Data were extracted as the frequency of occurrence of marketing claims, presence of regulatory information, product types, and flavors of e-juice as per a predefined codebook based on published literature. We also extracted textual details published on the websites about marketing claims, and slogans.
Results
Most retailer websites provided contact information and physical store addresses (83%) but only half had ‘click through’ age verification (57%) that seldom needed any identification proof for age (3%). Marketing claims were related to health (47%), smoking cessation (37%), and modernity/trend (37%) and none had health warnings. Promotional strategies were discounts (80%). starter kits (57%) and email subscriptions (53%). Product types displayed were rechargeable (97%) and disposable (87%) devices and e-liquids (90%) of an array of flavors (> 100). Nicotine presence, its concentration, and “nicotine is an addictive chemical" were displayed in 93%, 53%, and 23% of websites respectively.
Conclusion
Surveillance of content displayed online on e-cigarette retailer websites and regulation of online marketing and sales are needed to prevent youth access and initiation.
Thermal and spectroscopic properties of fluoride contaminated soil 21 o 32 ’ 41 ’’ N to 86 o 48 ’ 55 ’’ E of Odisha, India
Authors: Sahoo Rajat , Jena Abhipsa , Swain Trilochan 
Published: August 2023

Abstract

The primary purpose of this investigation is to know thermal properties of soil and extraction of fluoride and its quantitative determination. This study was also carried out to know the fluoride contamination after acid treatment of soil. The specific heat capacity (CP) is measured in heat flux DSC (Differential Scanning Calorimetry) at the heating rate of 2 K min− 1 in an N2 atmosphere using the sapphire standard. The elemental analysis, 19F NMR, TG-DTA, and ATR-IR are carried out for the determination of composition in soil. Fluoride ion is determined using ion selective electrode. This ATR-IR spectrum of soil indicates that Fe, Al and Si, containing fluoride minerals are present in the soil. The CP of this fluoride-contaminated soil is found to be less at higher temperatures and greater at room temperature as compared to other soils. The soil is contaminated with fluoride, confirmed using 19F NMR measurement. The optical band gap calculation from Kubelka–Munk relation indicates that soil is highly insulator. The reflection characteristic is confirmed by Diffuse Reflectance Spectrum (DRS). The concentration of fluoride in 1kg of soil is 12.79 g. as fluoride minerals.The less endothermic behaviour of soil at high temperatures and high endothermic at room temperature further makes the weather extremely hot in summer and cold in winter. The soil still contaminated with fluoride minerals after acid treatment. The minerals release fluoride ion in alkaline medium that is measured using ion selective electrode.
A novel JAK1 inhibitor SHR0302 for treatment of chronic Graft-verse-Host Disease: a preclinical study and Phase I clinical trial
Authors: Qiu Huiying , Sun Xi , He Qiaomei , Niu Jiahua , Yang Jun , Wang Ying , Huang Chongmei , Zhou Kun , Tong Yin , Cai Yu , Dong Baoxia , Wan Liping , Song Xianmin 
Published: August 2023

Abstract
Chronic graft-versus-host disease (cGVHD) is a frequent and potentially life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Standard steroid first-line treatment could not satisfy therapeutic need due to its limited efficacy. SHR0302 is a highly selective Janus kinase (JAK) 1 inhibitor, which could alleviate symptoms and improve the survival of cGVHD mice in our preclinical study. We therefore conducted a phase I clinical trial to evaluate the safety and efficacy of SHR0302 plus prednisone as first-line treatment for moderate/severe cGVHD. A 3+3 design was implemented to define the optimal dose of SHR0302, which included five dose levels (1mg/2mg/4mg/6mg/8mg once a day). Meanwhile, prednisone was concurrently administrated with a dose of 1mg/kg/d and then gradually tapered after two weeks. The primary endpoint was safety, and the secondary endpoints were overall response rate (ORR) at day 28 and week 24. Eighteen patients were enrolled into the study. A maximum tolerated dose was not reached. All patients (100%) experienced adverse events (AEs), and 7 patients (38.89%) experienced grade≥3 AEs. No patient was discontinued treatment due to AEs. At week 4, the ORR and complete remission (CR) rates were 94.44% and 27.77%, while at week 24, were 82.35% and 64.71%, respectively. The event-free survival (EFS) at 24 months was 72.20% (95% CI, 51.40%-93.00%). In summary, SHR0302 in combination with prednisone had a high safety and could achieve a high response for naïve-treatment cGVHD, which suggest that SHR0302 combination might be an optimal choice for naïve-treatment cGVHD.
First record of albinism in the Chinese fanray, Platyrhina sinensis (Elasmobranchii: Myliobatiformes: Platyrhinidae)
Authors: Zhuang Yan , Ke Shuting , Chen Mingru , Xiao Jiamei 
Published: August 2023

Abstract
A female albino fanray was found in the eighth seafood market (Siming District, Xiamen City, Fujian Province, China), having been captured in the southern Taiwan Strait in April 2022. Based upon morphological measurements and DNA barcoding, it was identified as the Chinese fanray, Platyrhina sinensis (Bloch&Schneider, 1801). Morphometrics are reported, and with no retainment of pigmentation in skin, while irises pigmentation is normal, the specimen is considered as a partial albinism (leucism). The specimen is an adult female, with normal shape, normal body length, normal body mass and normal external structure. As an offshore fish, the albinism individual has more difficulties to avoid predators to reach adult size, which is rare in nature. This represents the first reported case of albinism in the family Platyrhinidae and one of a rare record of albinism within chondrichthyans, which provides new reference and basis for the physiological and ecological research of albino fish.
Good feasibility of ozone-microwave treatment as a sterilization technology to extend the edible life of candied fruit as a post-processed fresh fruit product
Authors: Huang Haoran , Ni Zeping , Xie Jiawen , Li Yuyao , Wen Huicui , Huang Zitong , Situ Wenbei , Song Xianliang 
Published: August 2023

Abstract
In order to solve the problem of infestation of fresh fruit after making them into candied fruit and the quality degradation caused by the infestation, a combined ozone–microwave sterilization method was used to treat four candied fruit molds. Response surface optimization analysis showed that when the ozone infusion time was at 10 min and with 560 W microwave power for 20 s, the inhibition rates of the four candied fruit molds S1, S2, X1, and H1 were 100%, 94.28%, 100%, and 100%, respectively. Moreover, according to the characterization of morphology, DNA electrophoretic profiles, and nucleic acid/protein leakage test, the integrity of the mold cell membrane was destroyed after the combined ozone–microwave treatment because of the thermal and nonthermal effects of microwave and the strongly oxidizing properties of ozone. The molds were dead because of the efflux of intracellular nucleic acid and protein and the degradation of DNA, which influenced normal cellular metabolism. Quality identification showed a better expected quality of candied fruit.
Cervical Cancer Screening: Artificial Intelligence Algorithm For Automatic Diagnostic Support
Authors: Mirugwe Alex , Ashaba Clare 
Published: August 2023

Abstract
Introduction: Cervical cancer is the fourth most prevalent cancer among women worldwide and is a significant contributor to cancer-related deaths, with an estimated 300,000 women losing their lives to the disease annually. Most of these fatalities occur in low and middle- income countries (LMICs), such as Uganda, where access to screening and treatment options is limited. Early detection of cervical cancer is crucial to improve the chances of survival for patients. Currently, cervical cancer screening is typically performed through Pap smears, which involve manual examination of cervical samples for abnormalities by medical experts. This process is costly, time-consuming, and prone to errors, leading to inaccurate diagnoses. Therefore, it is essential to find more effective and efficient alternative methods for cervical cancer screening to improve access in LMICs and alleviate the burden of cervical cancer.
Objective: The purpose of this study is to develop an automated pre-cervical cancer screening algorithm to detect precancerous cervical lesions.
Methodology: We developed a cancer screening algorithm using a 21-layer deep-learning convolution neural network trained on a dataset of 2300 images collected from local sources and some obtained from Kaggle.
Results: The best-performing classifier had an AUC of the accuracy of 91.37%, a precision of 88.80%, a recall of
94.69%, an F1 score of 91.65%, and an AUC of 96.0%.
Conclusion: The development and implementation of automated pre-cervical cancer screening algorithms have the potential to revolutionize cervical cancer detection and contribute significantly to reducing the burden of the disease, particularly in resource-limited settings.
Catchment and climatic influences on spatio-temporal variations in suspended sediment transport dynamics in rivers
Authors: Shin Jae hun , Grabowski Robert C. , Holman Ian 
Published: August 2023

Abstract

Suspended sediment concentration (SSC) is an important attribute for water resources management. However, the interactions between climate and catchment characteristics that control the temporal variability of SSC in rivers are not fully resolved. The study aim is to evaluate how these variables influence spatial and seasonal variations in SSC dynamics at a continental scale. Daily SSC (mg/l) and site attribute data from 120 sites (USA) with minimum 10 years of record (1971–2000) were analysed. New indicators of SSC dynamics (magnitude and frequency) were developed and applied annually and seasonally. Geographically weighted regression (GWR) models were created for each ordinary least squares (OLS) regression model, and GWR coefficients were analysed by ecoregion. Land cover, rainfall and erosivity, baseflow index and soil texture were the most common variables in the OLS models. GWR coefficients displayed significant variation across the continent. Agricultural cover was positively associated with low frequency SSC events, while urban and forest cover predicted higher frequency events, except in the desert areas. PPT30 was generally a negative predictor for SSC magnitude, except the marine west coasts forests. These findings on catchment and climate controls on SSC will support future predictive models of SS transport dynamics.
Abordagem da espiritualidade do paciente em tratamento para o câncer
Authors: Longuiniere Agnes Claudine Fontes De La , Penha Júlia Maria Nascimento , Santos Maria da Conceição Quirino dos , Bastos Norma Lopes de Magalhães Velasco , Yarid Sérgio Donha 
Published: August 2023

Objetivo: Compreender o papel da espiritualidade na vida de pacientes oncológicos, além de conhecer a opinião destes pacientes sobre a abordagem da dimensão espiritual durante seu tratamento de saúde. Método: Trata-se de uma pesquisa descritiva e exploratória, de abordagem qualitativa, que teve como estratégia de investigação o ensaio clínico randomizado realizado numa Unidade de Assistência de Alta Complexidade em Oncologia, vinculada a um Hospital Geral público na Bahia. Participaram da pesquisa 30 pacientes oncológicos. Resultados: Os participantes desta pesquisa apontam que a espiritualidade, fé e crenças religiosas têm um papel importante no contexto do tratamento contra o câncer, sobretudo por trazer força e esperança durante a quimioterapia. Além disto, a maioria relatou que gostaria que esta dimensão fosse abordada durante seu tratamento de saúde, reconhecendo a importância da inclusão da sua espiritualidade no plano terapêutico. Conclusão: Apesar de não serem identificadas diferenças no enfrentamento do câncer após a inclusão da espiritualidade no tratamento quimioterápico, observa-se que as principais maneiras que o paciente utiliza para enfrentar o diagnóstico e tratamento do câncer envolvem questões relacionadas à espiritualidade. Nesse sentido, a espiritualidade constitui-se como um recurso que pode ser utilizado para o bem-estar e qualidade de vida, além de colaborar no enfrentamento de doenças.
Palavras-chave: Espiritualidade; Saúde Holística; Neoplasias; Adaptação Psicológica; Ensaio Clínico.
Trajetória do Adolescente nas redes de apoio à Saúde Mental: reflexões sobre a busca por qualidade de vida
Authors: Silva Thiago Nogueira , Claudia Mara de Melo Tavares  , Marilei de Melo Tavares  , Fabiana Ramos Vargas  , Marcia Cristina Moccellin  , Luciano Barbosa da Silva  
Published: August 2023

Introdução: Este artigo de reflexão teórica tem como objetivo analisar a trajetória do adolescente nas redes de apoio a saúde mental na busca por qualidade de vida. Materiais e Métodos: Reflexão teórica, que identificou, após exclusão dos estudos duplicados e aplicação dos critérios de elegibilidade, trinta artigos, textos e documentos nas bases de dados: Portal Regional da Biblioteca Virtual em Saúde (BVS) e na Scientific Eletronic Library Online (ScIELO). Resultados: Os 21 artigos, documentos e textos foram sintetizados e dispostos em tópicos para melhor exposição das informações. Discussão: Há destaque na relevância da trajetória terapêutica e os caminhos de usuários adolescentes em busca de saúde mental e qualidade de vida, para haver intervenção nesse cenário, deve se ter noção da organização das redes de atenção à saúde e os componentes das redes de apoio a saúde mental adolescente que fazem parte da busca por qualidade de vida, incluindo o destaque para a espiritualidade e religião como componentes das redes substitutivas de apoio a saúde mental adolescente na busca por qualidade de vida. Considerações finais: Assim, a construção de redes deve ser ativa e, ainda precisa haver, esforço para estabelecimento de relações que favoreçam as possibilidades de trabalho em parceria e diálogo entre usuários adolescentes, profissionais e demais elementos que fazem parte da rede de apoio.
Palavras-Chave: Saúde do Adolescente, Saúde Mental, Promoção da Saúde, Qualidade de Vida.
Infarto agudo do miocárdio no Rio de Janeiro: análise epidemiológica entre 2010 a 2019
Authors: Santos Figueredo Letícia , Moreira Alvarenga Vitor 
Published: August 2023

No Brasil, o infarto agudo do miocárdio (IAM) é a mais grave manifestação de doença arterial coronariana e seu número de internações cresce a cada ano. Com o processo de envelhecimento da população, as chances de ocorrência da doença também aumentam, uma vez que os fatores de risco são maiores. Diante disso, o objetivo do estudo foi realizar uma análise epidemiológica relacionada ao infarto agudo do miocárdio no estado do Rio de Janeiro, no período de janeiro de 2010 a dezembro de 2019. Foi realizado um estudo observacional e descritivo, através da coleta de dados a partir do Sistema de Informações Hospitalares/Sistema Único de Saúde (SIH/SUS) – DATASUS, acerca do CID-10 I21, na qual foi avaliado internações, óbitos e taxa de mortalidade por sexo, faixa etária e região de saúde. De acordo com esses dados, nos últimos dez anos, foram realizadas 73.541 internações por IAM, sendo mais prevalente em idosos, os quais também foram os que mais evoluíram para óbito. Em relação às regiões de saúde, observa-se que as internações ocorreram mais nas regiões metropolitanas I e II. No entanto, as maiores taxas de mortalidade foram na região metropolitana II e noroeste. Em relação ao sexo, mulheres são menos internadas, porém tem maior taxa de mortalidade. Nesse sentido, é possível avaliar as principais causas e fatores de risco para sua ocorrência na população, a fim pode ajudar a estabelecer um plano para maior prevenção primária e controle de fatores de risco, para reduzir a incidência da doença, e consequentemente, a necessidade de internação.

Palavras-chave: Infarto agudo do miocárdio; Epidemiologia; Internação.
Low Dose Olanzapine in the Prevention and Treatment of Carboplatin Induced
Nausea and Vomiting: A Prospective Clinical Randomized Controlled Trial
Authors: An Yun , Zhang Zewei , Gu Min , Zhao Juan , Jiang Caihong , Zhao Lanzhen , Jiang Ying , Li Hui , Liu Guang , Jin Gaowa , Li Quanfu 
Published: August 2023

Objective:
This study aimed to determine the effectiveness and safety of 5 mg olanzapine (OLZ) in
preventing vomiting and nausea caused by carboplatin chemotherapy.

Methods:
All patients with malignant tumors (n = 113) who underwent Carboplatin (AUC ≥ 5) treatment were
randomly categorized into two groups: the standard group (n = 57) and the OLZ regimen (n = 56). The major
endpoints of the trial were the TC (total control) between two groups during the OP (Overall phase, 0-120
hours), DP (delayed phase, 25-120 hours), and AP (acute phase, 0-24 hours). The secondary endpoints were the
CR (complete response) and TP (total protection) during AP, OP, and DP. The time of first vomiting was compared
between the two groups using Kaplan-Meier curves. The impact of CINV on the quality of life was assessed
by the Functional Living Index-Emesis (FLIE). OLZ-related side effects were also recorded.

Results:
(1) The primary endpoint TC rates were more favorable in the OLZ regimen group than in the standard
group during the AP 87.50% (49/56) vs. 63.15% (36/57) P = 0.003, OP 62.50% (35/56) vs. 31.57%
(18/57) P = 0.001, and DP 64.28% (36/56) vs. 33.33% (19/57) P = 0.001. (2) The secondary endpoints TP were
82.14% (46/56) vs. 63.15% (36/57), P = 0.024, 83.92% (47/56) vs. 63.15% (36/57). P = 0.012 during the DP
and OP. There was no statistical significance during AP between the two groups. The CR rates were not statistically
different between the two groups during the three periods, P > 0.05; (3) The first vomiting time in the
OLZ group was delayed compared with the standard group (P = 0.248). The effect on life quality (score ≥ 108)
assessed by FLIE was 62.50% vs. 43.48% between the two groups, P < 0.05. The primary side effects of OLZ
are fatigue (85%) and somnolence (75%). The primary side effects of the standard group are fatigue (77%) and
loss of appetite (85%).

Conclusion:
The 5 mg OLZ-based triple antiemetic regimen is effective and safe in preventing vomiting and
nausea induced by Carboplatin.
Recent Progress and Challenges in the Development of Edible Vaccines
Produced by Genetically Modified Plants
Authors: Singh Smita , Singh Pranjal Kumar , Sachan Kapil , Garg Sakshi , Sharma Alok Nath 
Published: August 2023

Abstract:
Biotechnologists have pioneered the idea of an edible vaccination in recent years. Subunit
vaccines, such as those used to create edible vaccines, involve the introduction of certain genes
into transgenic plants, which are subsequently coaxed into producing the corresponding protein. Bananas,
potatoes, legumes, lettuce, soybeans, corn, and rice are all examples of foods that fall under
this category. They have a low unit cost, can be stored conveniently, and are simple to administer
to patients of varying ages. There is great hope that the use of edible vaccinations, particularly in
underdeveloped countries, could drastically reduce the prevalence of diseases, including measles,
cholera, hepatitis B, and diarrhea. The development of effective and widely applicable edible vaccination,
however, faces a number of technological and regulatory hurdles. When compared to traditional
immunizations, edible vaccines offer significant cost savings, increased productivity, and reduced
risk. It raises the possibility of a more efficient approach to illness prevention. This article includes
important uses, production, host plants, benefits, drawbacks, mechanism of action, and
many regulatory difficulties related to edible vaccines. In this article, we have discussed the most
recent developments and successes with edible and intradermal vaccines in terms of the system
used for immunogen production, the molecular properties of these vaccines, and their ability to generate
a protective systemic and mucosal response.
Ambient Temperature and Cardiac Biomarkers: A Meta-Analysis
Authors: Khan Muhammad Ismail , Rasheed Zafar 
Published: August 2023

Abstract:
This study quantified the effect of cold or heat exposure of ambient temperature on the
alteration of well-known cardiac markers. A meta-analysis was performed using the PRISMA
guidelines. Peer-reviewed studies on ambient temperature and cardiac biomarkers were retrieved
from MEDLINE, ScienceDirect and Google Scholar from January 2000 to February 2022. The
pooled effect sizes of ambient temperature on cardiac biomarkers c-reactive protein, soluble-cell
adhesion-molecule-1, soluble-intercellular-adhesion-molecule-1, total cholesterol, low-densitylipoprotein,
interleukin-6, B-type-Natriuretic-Peptide; systolic/diastolic blood pressure were quantified
using a random-effects meta-analysis. A total of 26 articles were included in the metaanalysis
after screening the titles, abstracts and full texts. The pooled results for a 1°C decrease of
ambient temperature showed an increase of 0.31% (95% CI= 0.26 to 0.38) in cardiac biomarkers
(p=0.00; I-squared=99.2%; Cochran’s Q=5636.8). In contrast, the pooled results for a 1°C increase
in ambient temperature showed an increase of 2.03% (95% CI= 1.08 to 3.82) in cardiac biomarkers
(p=0.00; I-squared=95.7%; Cochran’s Q=235.2). In the cardiovascular (CV) population, the percent
increase in cardiac biomarkers levels due to a decrease/increase in ambient temperature was
greater. This study showed the decrease/increase in ambient temperature has a direct correlation
with the alterations in cardiac biomarkers. These findings are useful for managing temperatureassociated
cardiovascular mortality.

Registration:
This meta-analysis is registered on the National Institute for Health and Care Research
(NIHCR) for the PROSPERO with registration ID CRD42022320505.