bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Continuous Versus Periodic Vital Sign Monitoring on Disease Severity of Patients with an Unplanned ICU Transfer
Authors: Eddahchouri Yassin , Peelen Roel V. , Koeneman Mats , van Veenendaal Alec , van Goor Harry , Bredie Sebastian J. H. , Touw Hugo 
Published: April 2023

AbstractContinuous vital sign monitoring (CM) may detect ward patient’s deterioration earlier than periodic monitoring. This could result in timely ICU transfers or in a transfer delay due to misperceived higher level of care on the ward. The primary objective of this study was to compare patient’s disease severity upon unplanned ICU transfer, before and after CM implementation. We included a one-year period before and after CM implementation between August 1, 2017 – July 31, 2019. Before implementation, surgical and internal medicine patients’ vital signs were periodically monitored, compared to continuous monitoring with wireless linkage to hospital systems after implementation. In both periods the same early warning score (EWS) protocol was in place. Primary outcome was disease severity scores upon ICU transfer. Secondary outcomes were ICU and hospital length of stay, incidence of mechanical ventilation and ICU mortality. In the two one-year periods 93 and 59 unplanned ICU transfer episodes were included, respectively. Median SOFA (3 (2–6) vs 4 (2–7), p = .574), APACHE II (17 (14–20) vs 16 (14–21), p = .824) and APACHE IV (59 (46–67) vs 50 (36–65), p = .187) were comparable between both periods, as were the median ICU LOS (3.0 (1.7–5.8) vs 3.1 (1.6–6.1), p.962), hospital LOS (23.6 (11.5–38.0) vs 19 (13.9–39.2), p = .880), incidence of mechanical ventilation (28 (47%) vs 22 (54%), p.490), and ICU mortality (11 (13%) vs 10 (19%), p.420). This study shows no difference in disease severity upon unplanned ICU transfer after CM implementation for patients who have deteriorated on the ward.
On the use of adjoint gradients for time-optimal control problems regarding a discrete control parameterization
Authors: Lichtenecker Daniel , Rixen Daniel , Eichmeir Philipp , Nachbagauer Karin 
Published: April 2023

AbstractIn this paper, we discuss time-optimal control problems for dynamic systems. Such problems usually arise in robotics when a manipulation should be carried out in minimal operation time. In particular, for time-optimal control problems with a high number of control parameters, the adjoint method is probably the most efficient way to calculate the gradients of an optimization problem concerning computational efficiency. In this paper, we present an adjoint gradient approach for solving time-optimal control problems with a special focus on a discrete control parameterization. On the one hand, we provide an efficient approach for computing the direction of the steepest descent of a cost functional in which the costs and the error in the final constraints reduce within one combined iteration. On the other hand, we investigate this approach to provide an exact gradient for other optimization strategies and to evaluate necessary optimality conditions regarding the Hamiltonian function. Two examples of the time-optimal trajectory planning of a robot demonstrate an easy access to the adjoint gradients and their interpretation in the context of the optimality conditions of optimal control solutions, e.g., as computed by a direct optimization method.
Third-Country Effects of Export Incentives
Authors: Ledyaeva Svetlana 
Published: April 2023

AbstractThe existing empirical literature on export promotion policies is almost exclusively focused on their effects for domestic exporters. This paper contributes to this research by empirically examining the effects of export incentives for third-country exports. Using novel CEPR Global Trade Alert data, the study investigates the impact of Brazilian, Indian and Chinese export incentives on exports of OECD and emerging countries. The findings confirm the existence of negative third-country effects of export incentives and demonstrate that these effects are expectedly larger for foreign exporters who exhibit higher similarity in geography of export with subsidized exporters. These results further point to the importance of destination diversification in export strategies. Following strategic trade theory, the study further examines the moderating effect of industries` proclivity to imperfect competition for third-country effects of export incentives. Whereas Chinese export incentives, as predicted by strategic trade theory, cause largest negative effects in industries with higher proclivity to imperfect competition, Brazilian and Indian export incentives, contrarily, cause larger negative third-country effects in industries with lower proclivity to imperfect competition.
A survey of leaf phosphorus fractions and leaf economic traits among 12 co-occurring woody species on phosphorus-impoverished soils
Authors: Tsujii Yuki , Fan Baoli , Atwell Brian J. , Lambers Hans , Lei Zhangying , Wright Ian J. 
Published: April 2023

Abstract
Background and Aims
The leaf economic spectrum (LES) is related to dry mass and nutrient investments towards photosynthetic processes and leaf structures, and to the duration of returns on those investments (leaf lifespan, LL). Phosphorus (P) is a key limiting nutrient for plant growth, yet it is unclear how the allocation of leaf P among different functions is coordinated with the LES. We addressed this question among 12 evergreen woody species co-occurring on P-impoverished soils in south-eastern Australia.

Methods
Leaf ‘economic’ traits, including LL, leaf mass per area (LMA), light-saturated net photosynthetic rate per mass (Amass), dark respiration rate, P concentration ([Ptotal]), nitrogen concentration, and P resorption, were measured for three pioneer and nine non-pioneer species. Leaf P was separated into five functional fractions: orthophosphate P (Pi), metabolite P (PM), nucleic acid P (PN), lipid P (PL), and residual P (PR; phosphorylated proteins and unidentified compounds that contain P).

Results
LL was negatively correlated with Amass and positively correlated with LMA, representing the LES. Pioneers occurred towards the short-LL end of the spectrum and exhibited higher [Ptotal] than non-pioneer species, primarily associated with higher concentrations of Pi, PN and PL. There were no significant correlations between leaf P fractions and LL or LMA, while Amass was positively correlated with the concentration of PR.

Conclusions
Allocation of leaf P to different fractions varied substantially among species. This variation was partially associated with the LES, which may provide a mechanism underlying co-occurrence of species with different ecological strategies under P limitation.
Hemispheric Sunspot Numbers from the Astronomical Observatory of the University of Valencia (1940 – 1956)
Authors: Carrasco V. M. S. , Aparicio A. J. P. , Gallego M. C. , Vaquero J. M. 
Published: April 2023

AbstractIn this work, we present hemispheric sunspot number counts made in the Astronomical Observatory of the University of Valencia for the period 1940 – 1956. We found these data in a secondary source (the bulletins of the Madrid Astronomical Observatory). We digitized the hemispheric sunspot number and group number recorded by the observers. Unfortunately, the sunspot positions or areas were not published in this secondary source. A machine-readable version of the dataset is available as supplementary material. We compare the Valencia hemispheric series with others from other observatories, such as the Madrid Astronomical Observatory, finding similar hemispheric behaviors. We also computed the asymmetry index from the hemispheric data. We found that the northern hemisphere was predominant in our study period (declining phase of Solar Cycle 17, Solar Cycle 18, and rising phase of Solar Cycle 19), and the southern hemisphere was leading. These results agree with those obtained in previous studies. Therefore, the Valencia hemispheric records are one more piece of information to know the behavior of the northern and southern hemispheres during the 20th century.
Antimicrobial peptides CS-piscidin-induced cell death involves activation of RIPK1/PARP, and modification with myristic acid enhances its stability and tumor-targeting capability
Authors: Li Ning , Jiang Xingmei , Ma Xiaowan , Qiu Xiaoju , Chang HuangHuang , Qiao Ying , Luo Hui , Zhang Qingyu 
Published: April 2023

AbstractOvarian cancer (OC) is a highly lethal gynecological malignancy, often diagnosed at advanced stages with limited treatment options. Here, we demonstrate that the antimicrobial peptide CS-piscidin significantly inhibits OC cell proliferation, colony formation, and induces cell death. Mechanistically, CS-piscidin causes cell necrosis by compromising the cell membrane. Furthermore, CS-piscidin can activate Receptor-interacting protein kinase 1 (RIPK1) and induce cell apoptosis by cleavage of PARP. To improve tumor targeting ability, we modified CS-piscidin by adding a short cyclic peptide, cyclo-RGDfk, to the C-terminus (CS-RGD) and a myristate to the N-terminus (Myr-CS-RGD). Our results show that while CS-RGD exhibits stronger anti-cancer activity than CS-piscidin, it also causes increased cytotoxicity. In contrast, Myr-CS-RGD significantly improves drug specificity by reducing CS-RGD toxicity in normal cells while retaining comparable antitumor activity by increasing peptide stability. In a syngeneic mouse tumor model, Myr-CS-RGD demonstrated superior anti-tumor activity compared to CS-piscidin and CS-RGD. Our findings suggest that CS-piscidin can suppress ovarian cancer via multiple cell death forms and that myristoylation modification is a promising strategy to enhance anti-cancer peptide performance.
Graphical Abstract
DNAJB4 promotes triple-negative breast cancer cell apoptosis via activation of the Hippo signaling pathway
Authors: Fang Fang , Mo Linglong , Pan Xiaofeng , Yang Ziquan , Huang Haoyu , Zhu Liangyu , Wang Yingying , Jiang Guoqin 
Published: April 2023

Abstract
Introduction
Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast cancer without effective targeted therapies. DNAJB4 (Dnaj heat shock protein family (Hsp40) member B4) is a member of the human heat shock protein family (Hsp40). The clinical significance of DNAJB4 in breast cancer has been reported in our previous study. However, the biological function of DNAJB4 in TNBC cell apoptosis remains unclear to date.

Methods
The expression of DNAJB4 in normal breast cells, breast cancer cells, four-paired TNBC tissues, and adjacent noncancerous tissues was quantified by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assay. The role of DNAJB4 in TNBC cell apoptosis was investigated using a number of gain- and loss-of-function in vitro and in vivo assays. The underlying molecular mechanisms in TNBC cell apoptosis were elucidated via Western blot assay.

Results
DNAJB4 expression was significantly downregulated in TNBC tissues and cell lines. DNAJB4 knockdown inhibited TNBC cell apoptosis and promoted tumorigenicity in vitro and in vivo, but DNAJB4 overexpression resulted in the opposite. Mechanically, DNAJB4 knockdown inhibited TNBC cell apoptosis through suppression of the Hippo signaling pathway, and the result was reversed after DNAJB4 overexpression.

Conclusions
DNAJB4 promotes TNBC cell apoptosis by activating the Hippo signaling pathway. Therefore, DNAJB4 may act as a prognostic biomarker and therapeutic target for TNBC.
Walter Marget and a brief history of paediatric infectious diseases in Munich, Germany
Authors: von Both Ulrich , Adam Dieter , Hübner Johannes 
Published: April 2023

AbstractTheodor Escherich (1857–1911) was one of the key players in early paediatric infectious diseases (PID). In fact, he can be regarded as the first paediatric infectious diseases physician and the founder of this subspecialty. During his long years in service for children, he spent 6 years at the Dr von Hauner children’s hospital (1884–1890), laying the foundations for PID clinical care and research in Munich. Walter Marget, founder of this journal and co-founder of the German Society for Infectious Diseases (DGI) graduated from medical school in 1946 and practised in Munich since 1967. His tireless efforts went into establishing close links between clinical paediatrics and microbiological diagnostics culminating in the foundation of the Department of Antimicrobial Therapy and Infection Epidemiology at the Dr von Hauner children’s hospital. Walter Marget was a key figure for PID in Germany having trained and supported many clinician scientists who followed in his footsteps. This article gives a brief overview of the history of PID in Munich while commemorating Walter Marget and his achievements in this field and for INFECTION.
Challenges and approaches when realizing online surface inspection systems with deep learning algorithms
Authors: Stephani Henrike , Weibel Thomas , Rösch Ronald , Moghiseh Ali 
Published: April 2023

AbstractUsing deep learning in complex online surface inspection systems is challenging due to different framework conditions. First, time restrictions in production are usually fixed in terms of clock rate and response time. Furthermore, these methods need a lot of data, while typically the data situation is thin in the beginning as well as continuously unbalanced: defects occur rarely and thereby providing few example data for learning, while the desired detection rate is 100%. Another important issue is that although defect catalogues exist, they often change, especially when automatic inspection is applied for the first time. This is due to imaging systems usually being able to detect more defects than visual-manual inspection, therefore production, management, and quality assurance usually reiterate their prior defect catalogues. However, data driven methods depend heavily on consistent annotation. Therefore, respective parties must be made aware of this issue on the one hand, on the other hand, annotation and reannotation must be easy and useable by non-experts. Related is the issue of parametrization and traceability. Both are not inherent to neural networks but must be provided to some level to help building trust in machine learning methods. In this paper, we present a quality inspection system that uses deep neural networks for defect detection under real production conditions in wood manufacturing. We will address how we systematically deal with the above issues both in terms of process and algorithm.
Displaced Memoryscapes – Archives of Hungarian Women Authors from Post-Yugoslavia
Authors: Roginer Oszkár 
Published: April 2023

AbstractThe article deals with archives of memoryscapes as remembered landscapes of a past society by Hungarian women authors from Yugoslavia. Divided into two separate cycles, it explores how an inhabited geography transgressed from the present into a past, and how it evolved via belletristic practices from the 1990s onward. The archive is therefore assessed as a cumulative development of text-worlds in prose, poetry, and drama by Hungarian women, who either remained in disintegrating Yugoslavia or emigrated to Hungary, both of which led mostly to uprootedness and a misinterpretation of their work. Accordingly, displaced as authors, who remember landscapes that are beyond official memory politics, their archive remained largely unnoticed and marginalised throughout the decades. Emerging in autobiographic writing and literary fiction equally, these memoryscapes are not idiosyncratic but are regulated and systemic representations of a time, a space, and a society. To display such a mnemonic agency, the article integrates the foucauldian notions of the archive with the thirdspace perspective of geocriticism within literary representation, as used in post-colonial thought. Eventually, this enables the exposition of the archive of these female memoryscapes of an ethnic minority not in relation to other “national” archives, or as auxiliary archives of a male perspective, but as a system of thirdspaces and representation in itself.
Robustness of Climate Models
Authors: Gluck Stuart 
Published: April 2023

AbstractRobustness with respect to climate models is often considered by philosophers of climate science to be a crucial issue in determining whether and to what extent the projections of the Earth’s future climate that models yield should be trusted. Wendy Parker and Lisa Lloyd have introduced influential accounts of robustness for climate models with seemingly conflicting conclusions. I argue that Parker and Lloyd are characterizing distinct notions of robustness and providing complementary insights. Confidence, if warranted, need be by virtue of causally consistent climate models rather than by agreement upon projections by a diverse range of models.
Petrogenesis and tectonic implications of the Early Carboniferous shoshonitic to calc-alkaline magmatic rocks of the southern Yili terrane, western Tianshan
Authors: Xing Hao , Xue Chunji , Zhao Xiaobo , Symons DTA , Niu Pengqiao 
Published: April 2023

AbstractIn the Yili terrane at Awulale mountain, most shoshonitic lavas are related to post-collision extension and were extruded during the Late Carboniferous to Early Permian (310–280 Ma). Herein, we evaluate a small-volume occurrence of shoshonitic magmas in the southern Yili terrane formed c. 346 Ma ago. The high MgO (Mg#) and positive Hf isotope values of the shoshonitic magmas indicate the input of juvenile mantle-derived material. Still, their high Ba–Sr signatures were likely inherited from the partial melting of previously metasomatized lithospheric mantle. We argue the shoshonitic magmatic activity recorded a syn-subduction extensional history in the Yili terrane. This interpretation is consistent with the magmatic records from Early Carboniferous A-type granite and magnesian andesite found in the Zhaosu–Adentao–Dahalajunshan area of the southern Yili terrane. Combined with the geological development in this area, we propose that the emergence of the shoshonitic rocks records either the retreat of the trench or the rollback of the Junggar oceanic slab that occurred at or before the 346.1 ± 3.1 Ma age of the rocks.
Reading in kindergarten Arabic-speaking children with low linguistic skills: A longitudinal study
Authors: Mansour-Adwan Jasmeen , Shalhoub-Awwad Yasmin , Cohen-Mimran Ravit , Khateb Asaid 
Published: April 2023

AbstractThe present longitudinal study aimed to explore the connections between different linguistic profiles at kindergarten and reading achievements at first grade. These profiles are based on the two-dimensional model (Bishop & Snowling, 2004), which associates reading skills with phonological and other language abilities. This model was examined mainly in Indo-European languages but scarcely in Arabic. Arabic-speaking children were assigned to four linguistic profiles in kindergartens: low language (LL; N = 111), low phonology (LPh; N = 120), low language and low phonology (LLLPh; N = 139), and typical language and typical phonology (TLTPh; N = 135). Multivariate analysis was used to compare their reading achievements at first grade, and the overlap between linguistic and reading profiles was estimated. The results revealed significant differences between the different linguistic profiles in all reading measures. LLLPh group gained lower scores in reading tasks compared to the other groups. Significant relationships have been found between linguistic and reading profiles indicating reading difficulties among 14.5% of the children from TLTPh, 63% of LLLPh, 35% of LL, and 35.6% of LPh. The findings support the relationship between low linguistic skills and reading difficulties and emphasize the potential roles of both phonological and language skills for reading.
Surgical strategies to address re-operative complex left ventricular outflow tract and thoracic aortic pathology: Cleveland Clinic children’s experience
Authors: Tucker Dominique L. , Lee Leah J. , Ahmad Munir , Shaheen Naseeb , Gupta Sohini , Najm Hani K. , Hammoud Miza Salim , Tretter Justin T. , Karamlou Tara 
Published: April 2023

AbstractBackground:Complex patients requiring operations on the left ventricular outflow tract, aortic valve, or thoracic aorta after previous repair of aortopathy constitute a challenging group, with limited information guiding decision-making. We aimed to use our institutional experience to highlight management challenges and describe surgical pearls to address them.Methods:Forty-one complex patients with surgery on the left ventricular outflow tract, aortic valve, or aorta at Cleveland Clinic Children’s between 2016 and 2021 following previous repair of aortic pathology were retrospectively reviewed. Patients with known connective tissue disease or single ventricle circulation were excluded.Results:Median age at index procedure was 23 years (range 0.25–48) with median of 2 prior sternotomies. Previous aortic operations included subvalvular (n = 9), valvular (n = 6), supravalvular (n = 13), and multi-level surgeries (n = 13). Four deaths occurred in median follow-up of 2.5 years. Mean left ventricular outflow tract gradients improved significantly for patients with obstruction (34.9 ± 17.5 mmHg versus 12.6 ± 6.0 mmHg; p < 0.001). Technical pearls include the following: 1) liberal use of anterior aortoventriculoplasty with valve replacement; 2) primarily anterior aortoventriculoplasty following the subpulmonary conus in contrast to more vertical incision for post-arterial switch operation patients; 3) pre-operative imaging of mediastinum and peripheral vasculature for cannulation and sternal re-entry; and 4) proactive use of multi-site peripheral cannulation.Conclusions:Operation to address the left ventricular outflow tract, aortic valve, or aorta following prior congenital aortic repair can be accomplished with excellent outcomes despite high complexity. These procedures commonly include multiple components, including concomitant valve interventions. Cannulation strategies and anterior aortoventriculoplasty in specific patients require modifications.
The use of neutrophil–lymphocyte ratio for the prediction of refractory disease and coronary artery lesions in patients with Kawasaki disease
Authors: Farias Juan S. , Villarreal Enrique G. , Savorgnan Fabio , Acosta Sebastian , Flores Saul , Loomba Rohit S. 
Published: April 2023

AbstractBackground:Kawasaki disease is a vasculitis that can lead to cardiac complications, including coronary artery disease and cardiogenic shock. Various scoring systems have been developed to determine those that will be refractory to routine intravenous immunoglobulin therapy or develop coronary artery disease. The objective of this study was to determine if the neutrophil–lymphocyte ratio could predict refractory disease and coronary artery lesions in patients with Kawasaki disease.Methods:A systematic review of the literature was performed to identify manuscripts describing comparisons of neutrophil–lymphocyte ratio between those who had refractory disease and those who did not, and between those who developed coronary artery lesions and those who did not. Mean difference was compared between groups. Areas under the curve were utilised to determine the pooled area under the curve.Results:12 studies with 5593 patients were included in the final analyses of neutrophil–lymphocyte ratio for the prediction of refractory disease. Neutrophil–lymphocyte ratio before therapy was higher in refractory disease with a mean difference of 2.55 (p < 0.01) and pooled area under the curve of 0.724. Neutrophil–lymphocyte ratio after therapy was higher in refractory disease with a mean difference of 1.42 (p < 0.01) and pooled area under the curve for of 0.803. Five studies with 1690 patients were included in the final analyses of neutrophil–lymphocyte ratio for the prediction of coronary artery lesions. Neutrophil–lymphocyte ratio before therapy was higher in coronary artery lesions with a mean difference of 0.65 (p < 0.01).Conclusion:The use of neutrophil–lymphocyte ratio may help physicians in the identification of patients at risk of refractory disease and coronary artery lesions in patients with Kawasaki disease.