bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body temperature, heart rate, and locomotor activity measured by bio-loggers before and after a progestogen+eCG treatment for artificial insemination in sheep: effect of pregnancy
Authors: Abecia J. A. , Canto F. , Plaza J. , Palacios C. 
Published: August 2023

Context The introduction of bio-sensors for monitoring real-time changes in physiological variables has helped understand how external factors affect an animal’s resiliency to stressors. Aims To quantify changes in temperature, heart rate, and locomotor activity in ewes during hormonal treatments for artificial insemination (AI) for up to 15 days after insemination. Method Twelve ewes received a surgically implanted subcutaneous bio-logger to record data every 5 min. One week later, ewes received an intravaginal sponge for 12 days and AI was performed 54 ± 1 h after sponge withdrawal. The data were divided into the following four periods: ‘sponge in’ (Days −14 to −2), ‘day before AI’ (Day −1), ‘day AI’ (Day 0), and ‘post-AI’ (Days 1–5, Days 6–10, and Days 11–15). Key results Ewes presented significantly (P < 0.001) higher mean temperature and activity, and a lower heart rate when the sponges were in place than they did in the days following AI. Mean body temperature in the ‘sponge in’ period and the ‘day before AI’, but not in ‘post-AI period’, differed significantly (P < 0.001) between pregnant and non-pregnant ewes. Non-pregnant ewes had a significantly (P < 0.001) higher heart rate than did pregnant ewes when sponges were in and in the ‘post-AI’ period. Non-pregnant ewes were significantly (P < 0.001) less active than were pregnant ewes in the ‘sponge in’ period and on Days 1–5 after AI; however, the former were significantly (P < 0.001) more active than were pregnant ewes on Days 11–15 after AI. Conclusions The subcutaneous bio-logger system documented 24-h variations in body temperature, heart rate, and locomotor activity before and after AI in ewes that had received an estrus-synchronising hormonal treatment. Pregnancy status affected those variables and their circadian fluctuations at the time of the hormonal treatment and in the ‘post-AI’ period. Implications Any device designed for use in the study of Precision Livestock Farming that allows a simple, non-invasive measurement of these variables might provide the basis for the development of a system that could identify females that are in an optimal state for insemination, and provide an early pregnancy prediction system.
K’gari (Fraser Island) World Heritage Area: evaluating change in plant species richness and composition over two decades
Authors: Ngugi Michael R. , Neldner Victor J. , Melzer Rhonda , Behrendorff Linda , Dodt William G. 
Published: August 2023

Context K’gari (Fraser Island) World Heritage Area in eastern Queensland is the largest sand island in the world and is characterised by a diversity of landscapes, ecosystem types and cultural values. The biodiversity values are threatened by degradation associated with increasing visitor numbers, inappropriate fire regimes, invasive plants and animals, and climate change. Aim This study investigated changes in vegetation community attributes (species richness and composition) monitored for over two decades. Methods Twenty-two long-term vegetation monitoring sites established in 1995 were resurveyed in 2021 and analysed. Key results The sites experienced between one to five fire events in the period from 1994 to 2020. Species richness and the overall differences within regional ecosystems through time were not statistically significant at P ≤ 0.05. A comparison between observed species in the 2021 survey against a list of expected species within each regional ecosystem showed no statistically significant difference (t7 = 0.649, P = 0.268). Recently burnt sites showed the greatest degree of dissimilarity. Six invasive plant species that are known environmental weeds were recorded. Conclusion Our research suggests that most vegetation communities in K’gari are adversely affected by widespread, severe bushfire but are resilient; except for Casuarina equisetifolia subsp. incana communities on exposed frontal areas and dry peat swamps. Implications Targeted planned burning is a key management tool that aims to achieve fire regimes appropriate to the ecosystems and to mitigate risk of severe bushfires. Hence, timely implementation of the existing planned burn guidelines for the south-east Queensland Bioregion is imperative.
A pH-responsive polymer-coated CaO2 as oxygen-generating nanoparticle in situ for enhanced chemo-photodynamic synergistic therapy against tumors
Authors: Chen Xiaolu , Song Ping , Li Wanzhen , Wang Jun , Gui Ting , Zhang Weiwei , Ge Fei , Zhu Longbao 
Published: August 2023

Abstract
Photodynamic therapy (PDT) has emerged as an efficient strategy for tumor treatment. However, Insufficient amounts of inherent hypoxia and intrinsic hydrogen peroxide (H2O2) in the tumor microenvironment severely constrained PDT, as oxygen is the critical substrate for photosensitivity reaction. Here, a pH-responsive H2O2 and O2 self-supplying hybrid nanoparticle was designed. Through, the calcium peroxide (CaO2) as carriers loading a chemotherapeutic drug a photosensitizer 5,10,15,20-tetrakis(4-aminophenyl) porphyrin (TAPP) and doxorubicin (DOX), was covered with polyacrylic acid (PAA) to build up a feature material DOX-TAPP-CaO2@OA@PAA (denoted as DTCOP) through the reverse microemulsion method. In the acidic tumor microenvironment conditions exposing the water-sensitive CaO2 nanocore to generate hydrogen peroxide (H2O2) and O2, the self-supplied O2 alleviates hypoxia to enhance the PDT, and releasing DOX and TAPP. Synthetic characterization shows that the succeeded synthesized Nanocarriers could effectively carry DOX and TAPP to the tumor site and release O2 at the low pH of TME. And the experimental results demonstrated that this interpose exogenous oxygen strategy is efficient at inhibition of tumor growth both in vitro and in vivo. The nanocomposite exhibits excellent biocompatibility and the ability to inhibit tumor growth and has significant potential for the treatment of hypoxic tumors.
Development of the first non-planar REBCO stellarator coil using VIPER cable
Authors: Riva N , Granetz R S , Vieira R , Hubbard A , Pfeiffer A T , Harris P , Chamberlain C , Hartwig Z S , Watterson A , Anderson D , Volberg R 
Published: August 2023

Abstract
The benefits of operating fusion devices, such as tokamaks and stellarators, at high fields make high-temperature superconducting magnets necessary to realize a compact fusion power system. Superconducting stellarators, such as W7-X, have used standard low-temperature superconductor technology niobium-titanium. ARPA-E has recently funded a two-year project led by the startup Type One Energy and involving the Fusion Technology Institute at the University of Wisconsin-Madison, the Plasma Science to design and fabricate the first non-planar high-temperature superconductor (HTS) rare-earth barium copper oxide (REBCO) coil for a high-field stellarator based on the SPARC tokamak’s VIPER cable concept. The design consists of a 1.5-turn non-planar REBCO coil supported by a pair of 3D printed stainless steel radial plates. The ultimate goals of the project are to determine if commercial REBCO tapes and additive manufacturing can be used to fabricate high field (

⩾
10
T

) non-planar coils with tight bending radii (

≃

100

m
m

) and with a degradation of the critical current smaller than 20% with respect to the expected performance. In this work we present numerical analysis for non-planar coils (critical current, magnetic field map, Lorentz forces and quench aspects) at the operating conditions of 77 K and 20 K and the fabrication and testing in liquid nitrogen (77 K) of the first two non-planar demonstrators for stellarators based on a VIPER cable. The first demonstrator is a short NOn-planar VIPER cabLe (cable demonstrator at which we will refer to as NOVEL) equipped with 100 HTS REBCO tapes and with a critical current of 5700 A at 77 K (self-field); the second is a MultIple turns (1.5-turns) NOn-plANar coil (coil demonstrator at which we will refer to as MINOAN) equipped with 30 HTS tapes and with a critical current of 2100 A at 77 K (self-field). Both demonstrators were tested at 77 K (liquid nitrogen bath) and the results showed that—even after being bent into non-planar shapes with bend radii

≃

100

m
m

—the degradation of the critical current

I

c

was within 15%, meeting the expected goals of the project.
Online community photo-sharing in entomology: a large-scale review with suggestions on best practices
Authors: Skvarla Michael J , Fisher J Ray 
Published: August 2023

AbstractOver the past 2 decades, digital photography has grown increasingly accessible. This has ushered in a golden age of community science, where nonspecialists share natural history observations from across the globe via digital media. Importantly, these observations are accessible to researchers, who can readily share expertise directly with the community and connect observations and observers with research projects. This has fueled a rising number of publications combining specialist and nonspecialist observations, which occasionally make national and international headlines. Entomology has embraced this trend, but the scope and impact are not clear. A review of its effect on the field is therefore warranted. Herein, we review and analyze publications that incorporated information from photographs shared on photo-sharing websites. In total, 2,123 publications that incorporated information from 77 photo-sharing websites were examined. Seven websites accounted for 66% of the publication citations. 84.6% of publications focused on data from the Holarctic ecoregion (56.2% Palearctic and 28.4% Nearctic). Forty-six arthropod orders were represented, but the Big Five—Lepidoptera, Coleoptera, Hymenoptera, Hemiptera, and Diptera—accounted for 75% of all publications. We divide the publications into 28 discovery and use categories, review how community photograph data has been used within each category, and provide examples of categories utilized in nonentomology natural history fields, which we hope will provide inspiration and spur future research. We also discuss benefits and considerations when using such data—including the accuracy of identifications, inherent biases, and digital data impermanence—and suggest best practices to follow.
The nutritional landscape in agroecosystems: a review on how resources and management practices can shape pollinator health in agricultural environments
Authors: Lau Pierre W , Esquivel Isaac L , Parys Katherine A , Hung Keng-Lou James , Chakrabarti Priyadarshini 
Published: August 2023

Abstract
Pollinator nutrition is a highly complex subject that we are just starting to unravel, from the multidimensional nature of bee forage (pollen and nectar) to how the abiotic environment can affect the resources available to bees. Doing so is of utmost importance, as improving pollinator resource availability and nutrition is one of the proposed mechanisms to improve populations and pollinator health. However, landscape change has changed the resources naturally available for pollinators. Farmland and cropping systems create a unique nutritional landscape for pollinators, with agroecosystems typically containing few crops dominating a landscape along with natural corridors containing noncrop plants. The types of crops planted and the surrounding landscape will ultimately affect the nutritional landscape bees have access to. Even the management practices in agriculture and how pests are controlled will, directly and indirectly, affect bee health and nutrition. Hence, a better understanding of bee nutrition in agricultural ecosystems is warranted. This review synthesizes research on bee nutritional ecology and the agricultural landscapes to advance our understanding of bee health in agriculture.
Two tumors with combined features of bronchiolar adenoma/ciliated muconodular papillary tumor and sclerosing pneumocytoma
Authors: Boland Jennifer M , Larsen Brandon T , Ryan Lori , Yi Eunhee S , Aubry Marie Christine 
Published: August 2023

Abstract

Objectives
Bronchiolar adenoma/ciliated muconodular papillary tumor (BA/CMPT) and sclerosing pneumocytoma (SP) are both rare and morphologically unique peripheral lung tumors with indolent behavior. These tumors have not been previously described as showing overlapping morphologic features and are generally genetically distinct.

Methods
Two cases were recently encountered that show hybrid morphologic features between BA/CMPT and SP, and the morphology and immunophenotype are described in detail.

Results
Both cases showed interstitial round cells typical of SP (TTF1+, EMA+), as well as areas more typical of BA/CMPT. One case showed BRAFV600E expression in the BA/CMPT areas but not in the SP-like cells.

Conclusions
Although it is possible that these cases represent collision tumors or are examples of unusual metaplastic epithelial changes in SP, they also raise the possibility that these 2 entities could occasionally coexist in true hybrid tumors.
The success rates of clinical cancer next-generation sequencing based on pathologic diagnosis: Experience from a single academic laboratory
Authors: Latham Katherine , Dong Fei 
Published: August 2023

Abstract

Objectives
This article aims to establish the relationship between pathologic diagnosis and the rate of success in cancer next-generation sequencing testing.

Methods
Clinical next-generation sequencing results performed for solid tumors were reviewed. The rate of success was analyzed in the context of tumor type and accompanying variables.

Results
Out of 683 total specimens, 533 (78.0%) underwent successful sequencing. The rate of success was 91.8% for ovarian carcinomas, 87.5% for lung non–small cell carcinomas, 82.0% for colorectal adenocarcinomas, 78.3% for melanomas, 75.9% for breast carcinomas, and 64.7% for pancreatic adenocarcinomas. For specimens that successfully underwent sequencing, pancreatic adenocarcinomas had the lowest median tumor proportion and somatic RAS and TP53 mutation allele fractions compared with other tumor types. Cytology specimens had a 33.3% success rate for pancreatic adenocarcinomas (5 of 15) and a 93.3% success rate for lung carcinomas (14 of 15). Compared with tissue from primary sites, tissue from metastatic sites showed a higher success rate for pancreatic adenocarcinomas and lower success rates for colorectal adenocarcinomas and melanomas.

Conclusions
The success rate of cancer next-generation sequencing testing is dependent on pathologic diagnosis, tissue site, and diagnostic procedure. Understanding which specimens are at higher risk for failing molecular testing may help pathologists and clinical care teams optimize tissue acquisition and usage for patient care.
Hybridization and polyploidization generate evolutionary diversification of the genus Buddleja in the Sino-Himalayan region. A commentary on ‘Deciphering complex reticulate evolution of Asian Buddleja (Scrophulariaceae): insights into the taxonomy and speciation of polyploid taxa in the Sino-Himalayan region’
Authors: Chen Chunlin , Liu Jianquan 
Published: August 2023

This article comments on:
Fengmao Yang, Jia Ge, Yongjie Guo, Richard Olmstead and Weibang Sun. Deciphering complex reticulate evolution of Asian Buddleja (Scrophulariaceae): insights into the taxonomy and speciation of polyploid taxa in the Sino-Himalayan region, Annals of Botany, Volume 132, Issue 1, 01 July 2023, Pages 15–28, https://doi.org/10.1093/aob/mcad022
Use of high- and low-value care among US adults by education levels
Authors: Park Sungchul , Nguyen Ann M 
Published: August 2023

Abstract

Background
Healthcare reform in the United States has focused on improving the value of health care, but there are some concerns about the inequitable delivery of value-based care.

Objective
We examine whether the receipt of high- and low-value care differs by education levels.

Methods
We employed a repeated cross-sectional study design using data from the 2010–2019 Medical Expenditure Panel Survey. Our outcomes included 8 high-value services across 3 categories and 9 low-value services across 3 categories. Our primary independent variable was education level: (i) no degree, (ii) high school diploma, and (iii) college graduate. We conducted a linear probability model while adjusting for individual-level characteristics and estimated the adjusted values of the outcomes for each education group.

Results
In almost all services, the use of high-value care was greater among more educated adults than less educated adults. Compared to those with no degree, those with a college degree were significantly more likely to receive all high-value services except for HbA1c measurement, ranging from blood pressure measurement (4.5 percentage points [95% CI: 3.9–5.1]) to colorectal cancer screening (15.6 percentage points [95% CI: 13.9–17.3]). However, there were no consistent patterns of the use of low-value care by education levels.

Conclusion
Our findings suggest that more educated adults were more likely to receive high-value cancer screening, high-value diagnostic and preventive testing, and high-value diabetes care than less educated adults. These findings highlight the importance of implementing tailored policies to address education-based inequities in the delivery of high-value services in the United States.
Parallel incorporation and public law
Authors: Edgar Andrew , Stack Kevin M 
Published: August 2023

Abstract
Over the past fifty years, domestic regulators have turned to standards developed by private organizations as a means of complying with international law commitments to eliminate barriers to trade. What impact does this phenomenon of parallel incorporation, in which regulators in different countries incorporate the same private standards, have on domestic administrative law and public law? Through a case study of US and Australian regulators’ adoption of the same standards in aviation, the article exposes how parallel incorporation exacerbates existing accountability deficits of administration, contributes to the hollowing out of public capacity to review these incorporations, defies conventional understandings of delegation, and breaches basic understanding of rulemaking processes in both the United States and Australia. Using conventional administrative processes to implement solutions compelled by international commitments strains and transforms these processes. In this context, trade law imperatives result in accommodations from domestic public law not the reverse.
A systematic review of economic evaluations of pharmacist services
Authors: Price Emilia , Shirtcliffe Andi , Fisher Thelma , Chadwick Martin , Marra Carlo A 
Published: August 2023

Abstract

Background
Challenges to the provision of health care are occurring internationally and are expected to increase in the future, further increasing health spending. As pharmacist roles are evolving and expanding internationally to provide individualised pharmaceutical care it is important to assess the cost-effectiveness of these services.

Objectives
To systematically synthesise the international literature regarding published economic evaluations of pharmacy services to assess their cost-effectiveness and clinical outcomes.

Methods
A systematic review of economic evaluations of pharmacy services was conducted in MEDLINE, EMBASE, PubMed, Scopus, Web of Science, CINAHL, IPA and online journals with search functions likely to publish economic evaluations of pharmacy services. Data were extracted regarding the interventions, the time horizon, the outcomes and the incremental cost-effectiveness ratio. Studies’ quality of reporting was assessed using the Consolidated Health Economic Evaluation Reporting Standard (CHEERS) statement.

Results
Seventy-five studies were included in the systematic review, including 67 cost-effectiveness analyses, 6 cost-benefit analyses and 2 cost-consequence analyses. Of these, 57 were either dominant or cost-effective using a willingness-to-pay threshold of NZ$46 645 per QALY. A further 11 studies’ cost-effectiveness were unable to be evaluated. Interventions considered to be most cost-effective included pharmacist medication reviews, pharmacist adherence strategies and pharmacist management of type 2 diabetes mellitus, hypertension and warfarin/INR monitoring. The quality of reporting of studies differed with no studies reporting all 28 items of the CHEERS statement.

Conclusions
There is strong economic evidence to support investment in extended pharmacist services, particularly those focussed on long-term chronic health conditions.
Genetic differentiation and species diversification of the Adoxophyes orana complex (Lepidoptera: Tortricidae) in East Asia
Authors: Tsai Cheng-Lung , Shih Li-Cheng , Yeh Wen-Bin , Byun Bong-Kyu , Jinbo Utsugi , Ning Fang-Yu , Sung I-Hsin 
Published: August 2023

Abstract
The Adoxophyes tea tortrix (Lepidoptera: Tortricidae) is a group of leaf rollers that cause enormous economic losses on tea and apple crops. In East Asia, taxonomic ambiguity of the Adoxophyes orana complex (AOC), which consists of A. orana, A. dubia, A. honmai, and A. paraorana, has persisted for decades because of vague diagnostic characters. In this study, differences in the AOC were examined to improve species identification, determine genetic variations, and develop control strategies. Analyses revealed that A. orana comprised 2 lineages, a widely distributed Palearctic lineage and an East Asian lineage that was nested with other Asian species. Genetic divergence of &gt;3% is proposed to confirm the AOC species that would benefit subsequent taxonomic revision. The monophyletic Taiwanese A. sp. with 2.8–4% from other AOC species appeared to suggest it as an independent taxon, and low interspecific divergence between A. honmai and A. dubia of 0.3% indicated possibility of recent divergence or intraspecific variations. Our result further suggested that the Z9-14:Ac ratio of semiochemicals could be a reference for the reblending of pheromone attractants in Taiwanese tea plantations. Moreover, the AOC species appeared to have a tendency of specific geographic distributions, with A. dubia and A. honmai in Japan and China, A. paraorana in Korea, and A. sp. in Taiwan. Maintaining the unique genetic composition of Adoxophyes species in each geographic region and preventing the possible invasions into those AOC-free countries through the transportation of host plants are essential in managing the AOC in East Asia.