bluuebunny/crossref_metadata_2025_split huggingface dataset:
The physical and dynamical analysis of the suspected binary asteroid (12499) 1998 FR47
Authors: Borisov Galin , Todorović Nataša , Bebekovska Elena Vchkova , Kostov Andon , Apostolovska Gordana 
Published: August 2023

Abstract

We present the R-band lightcurves of the Flora family asteroid (12499) 1998FR47, obtained in 2022 at two different astronomical sites: Bulgarian National Astronomical Observatory Rozhen (MPC 071) and Astronomical Station Vidojevica (MPC C89). The quadramodal lightcurves reveal a rotation period of6.172±0.003 h and an amplitude of about 0.44 mag. Using the lightcurve inversion method, with the combination of our dense lightcurves and the sparse data from DR3, we found the sidereal period, an indication of a retrograde rotation of (12499) and its low-convex resolution shape.
Nonetheless, the unusual shape of the quadramodal lightcurve and its additional analysis reveals two possible periods, 3.0834±0.0085 h and 4.1245±0.0151 h, making the suspect that the asteroid might be a non-synchronised wide binary system.
Spectral analysis of the asteroid using data from the GAIA DR3 shows that it is either an M- or an L-type object and maybe a piece of the first planetesimals to form in the Solar System protoplanetary disk.
On the other hand, our studies of (12499)’s dynamical properties indicate a sig-nificantly shorter lifetime. The asteroid lies on the border of the 7:4 mean motionresonance with Mars (7M:4), alternating between being in and out of it for almost190 Myrs. During 200 Myrs of integration, (12499) visited other resonances inthe Flora family, but it never became a Near Earth Object (NEO). Additionalintegration of fictive objects from the 7M:4 resonance showed that there is apossibility of transpiration to the NEO region already at about 20 Myrs.
Sprayable starch films for agricultural mulching
Authors: Anzorena Hector A. , López Olivia V. , Ninago Mario D. 
Published: August 2023

Abstract
Environmental sustainability has driven research into the development of biodegradable materials to address ecological challenges. In this study, biodegradable sprayable films were produced from thermally gelatinized cassava starch suspensions (5% w/v) to explore their potential application as protective coatings for agricultural soils. Starch gelatinization process was optimized to evaluate their feasibility to be applied by the spraying technique. Results showed that it is necessary to carry out a previous dilution of the gelatinized suspensions (1:4) to be able to spray them and form a uniform layer on the soil. To enhance films properties, it were introduced bentonite particles (0, 5, and 10% w/w starch basis) as reinforcement and sodium tetraborate (0 and 3% w/w starch basis) as crosslinking agent. A uniform bentonite particles distribution within the starch matrix was observed and films exhibited capacity to block UV and visible radiation, especially in the photosynthetically active radiation range. Tensile and puncture tests revealed that bentonite and borax presence increased the final films resistance, and biodegradability of the films was confirmed through water solubility and composting tests. The comprehensive findings from this study provide crucial insights for the implementation of eco-conscious innovations in crop cultivation and soil management techniques.
A many-objective optimization model for the end-of-life of buildings
Authors: Quéheille Eva , Taillandier Franck , Saiyouri Nadia , Fernandez Christophe 
Published: August 2023

Abstract

objectives
cost, delay, landfill rate, damages on resources, ecosystem quality and human health; the three last objectives are based on Life Cycle Assessment (LCA). Different constraints allow to ensure the operationality of the solutions. In order to allow a quick and easy instantiation of the model to any new demolition project, the model considers three types of data: the decision variables that will be optimized, the professional data that are valid on different study cases, and the study case parameters that are specific to the considered project. The optimization process is done via the DBEA genetic algorithm. The model was applied to a real study case and allows to build a set of pareto-optimal solutions. To assess the relevance of these solutions, an expert studied them and validated their interest and their feasibility. The diversity of solutions offered by the model is an advantage for the experts, as it offers new visions and the opportunity to explore new strategies.
Youth Unemployment and Rising Crime Rate in South Africa: Does Governance Matter?
Authors: AKINOLA Gbenga , Ohonba Abieyuwa 
Published: August 2023

Abstract
This study examined the nexus among governance, crime rates and youth unemployment in South Africa. The study’s objectives are: 1) to study the trending nexus on the categorical age-group of youth unemployment, crime rate and governance in South Africa. Variables proxying governance are the voice of accountability, political stability and the absence of violence/terrorism and regulatory quality 2) to investigate how crime rates and governance impact on unemployment in South Africa. Descriptive statistic forms the preliminary trend analysis; these alongside with dynamic auto-regressive distributive lag (ARDL) model have been engaged to achieve the study’s objectives. Governance series adopted in the model includes government voice of Accountability, Political Stability and Regulatory quality alongside age groups 45–54; 15–64, 35–44, 15–24; 25–34. The findings from ARDL model are reported from three separate regimes. From regime one, the findings indicate that in the long-run and holding other variables constant, only inflation and Political Stability indicator on the average rate significantly impact on youth unemployment. Increment in inflation would cause increment in the youth unemployment by 27 units but increment in Political Stability would decrease youth unemployment by 606 units. In the short-run, the main determinants of youth unemployment are inflation rate (CPI) and Political Stability in South Africa. The result revealed that unemployment gets worse in the long-run with higher inflation rate in the country. Policies to strengthen rule of law, control of corruption and government effectiveness could create wider employment opportunities for various categories of youths, reduce the crime rate at all level.
Building Envelope Design With PHASE-CHANGEMATERIALS (PCM).
Authors: BENACHIR NOUHAILA , Farida Bendriaa , MOUHIB TAOUFIQ 
Published: August 2023

Abstract

Building is one of the most energy consuming and CO2 producing sectors in the world. In Morocco, this sector currently accounts for 33% of total consumption nationwide. The new thermal regulation in Morocco aims at introducing energy efficient practices in this sector to reduce these consumptions. Indeed, in the Mediterranean region, the architecture of the building has a major impact on its energy and thermal performance. In addition, the integration of passive techniques and the use of local materials, phase change materials MCP could significantly reduce energy consumption in the building sector.Depending on the properties of the thermal zone where we are, it is therefore possible to integrate PCM and optimize their parameters in order to favorably diphase the energy consumption peaks and energy consumption and, by the same token, significantly reducing the use of the HC system. Consequently, the integration of this PCM in the envelopes of new buildings or in renovation would contribute to reduce the energy bill in the building sector in Morocco. So the (PCM) represents a sustainable alternative to reduce energy consumption for this a thermal dynamic simulation was realized with TRNSYS 204. Since PCM involves large latent heat at small temperature phase changes, PCM is used for temperature stabilization and for storing heat with large energy densities and capacity the storage in combination with rather small temperature changes. The simulation was carried out for the climate zone of Morocco (Casablanca Nouasseur). The results of the simulation showed that the use of phase change materials in brick walls reduced overheating in the summer period, decreasing the ambient temperature.
Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells
Authors: Takahashi Kenichi , Mashima Hirosato , Sekine Masanari , Uehara Takeshi , Asano Takeharu , Sun-Wada Ge-Hong , Wada Yoh , Ohnishi Hirohide 
Published: August 2023

Abstract
Rab7 is known to function in the autophagy and endocytosis pathways in eukaryocytes and is related to various types of diseases. We recently reported that Rab7 plays a protective role against acute pancreatitis. However, its physiological function in exocytotic cells remains unclear. Thus, we investigated the role of Rab7 using pancreas-specific Rab7 knockout mice (Rab7Δpan). Immunofluorescence microscopy revealed that Rab7 colocalized with amylase in pancreatic acinar cells of wild-type mice but not in Rab7Δpan mice. Western blotting confirmed Rab7 localization in on zymogen granule (ZG) membranes of wild-type mice. Cholecystokinin (CCK)-stimulated amylase secretion examined using isolated pancreatic acini was similar in Rab7Δpan and wild-type mice. In contrast, electron microscopy revealed that the diameters of ZGs were shorter and the number of ZGs larger in the pancreatic acinar cells of Rab7Δpan than in those of wild-type mice. However, the number of ZGs decreased in both Rab7Δpan and wild-type mice after 24 h of starvation. In addition, the amount of amylase in the pancreas was decreased in both Rab7Δpan and wild-type mice. These data indicate that Rab7 localized on ZGs plays a crucial role in the maturation of ZGs but not in their autophagy or regulated exocytosis in pancreatic acinar cells.
Effect of a new probiotic on Artemia cysts determined by a convolutional neural network
Authors: Evdokimov Ivan , Malkova Angelina , Irkitova Alena , Shirmanov Maxim , Dementev Dmitrii 
Published: August 2023

One of the problems in sea farming is infections that cause mass mortality of crustaceans. To fight infections and improve sanitary conditions, farmers are actively using probiotic preparations. We aimed to study the effect of a new probiotic based on Bacillus toyonensis B-13249 and Bacillus pumilus B-13250 strains on the incubation of Artemia franciscana cysts. Another purpose was to test a possibility of using a convolutional neural network for fast automatic counting of cysts, nauplii, and embryos.
A pilot batch of the probiotic was prepared at the Prombiotech Engineering Center, Altai State University, from two strains of spore bacteria from the Center’s collection: B. toyonensis B-13249 and B. pumilus B-13250.
The recommended amount of the probiotic was experimentally determined as 0.1 per 2 g of cysts. This concentration increased the number of hatched cysts by 1.4 and 10% in the batches from Lake Bolshoye Yarovoye (Z29.04) and from Lake Kuchuk (C9). It also increased the biomass yield to 7.40 ± 0.69 and 6.80 ± 0.43 g in these two batches, respectively, compared to the control samples where the yields were 5.30 ± 0.60 and 4.60 ± 0.50 g, respectively. The robot counter reduced the sample processing time 15 times and saved the data for further use.
The probiotic based on B. toyonensis B-13249 and B. pumilus B-13250 had a positive effect on the hatching rate and biomass yield of A. franciscana. The new method for rapid counting of Artemia, which was based on the convolutional neural network and developed as an application of the Artemeter-1 robot, reduced the processing time and lowered labor costs.
Coffee pulp pretreatment methods: A comparative analysis of hydrolysis efficiency
Authors: Phuong Do Viet , Nguyen Luu Thao 
Published: August 2023

The Vietnamese food industry produces a lot of coffee pulp, which is a valuable and abundant source of agricultural by-products. It contains a lot of cellulose, which can be converted into bioethanol. However, coffee pulp needs an extensive pretreatment to reduce the amount of lignin and hemicellulose while retaining the initial cellulose composition. This study compared several pre-hydrolysis and pre-fermentation pretreatment methods which involved H2SO4, NaOH, microwaves, and white rot fungus Phanerochaete chrysosporium.
The hemicellulose dropped by 43.8% after the acidic pretreatment, by 47.1% after the alkaline pretreatment, and by 12.8% after the microbial pretreatment. The lignin contents dropped by 4.2, 76.6, and 50.2% after acidic, alkaline, and microbial pretreatment, respectively. The removal of hemicellulose and lignin in the coffee pulp was much more efficient when two or three of the pretreatment methods were combined. The microwave-assisted acid and alkaline pretreatment was the most efficient method: it removed 71.3% of hemicellulose and 79.2% of lignin. The combined method also had the highest amount of reducing sugars and glucose in hydrolysate. Additionally, concentrations of such yeast inhibitors as 5-hydroxymethyl-2-furaldehyde (HMF) and furfural were 2.11 and 3.37 g/L, respectively.
The acid pretreatment was effective only in removing hemicellulose while the alkaline pretreatment was effective in lignin removal; the fungal pretreatment had low results for both hemicellulose and lignin removals. Therefore, the combined pretreatment method was found optimal for coffee pulp.
The Anthropocene and the Problem of Anthropological Constants
Authors: Podušelová Katarína 
Published: August 2023

In the humanities and social sciences, the concept of the Anthropocene has become the starting point for theoretical analyses of the immediate relationship between the environmental preconditions for the existence of civilization and the human actions whose consequences threaten these preconditions. From the philosophical-anthropological point of view, reflections on the concepts of the Anthropocene focus not only on a critical analysis of the claims about human that originate in the natural sciences but also on an understanding of the overall role of humanity in the new geological-climatic regime of the Earth. The primary purpose of this paper is to highlight two-pronged problem areas, which include both the problem of anthropological constants as specific ways of makingstatements about humans and the problem of using them to reflect on the conceptual system of the Anthropocene. In particular, this paper emphasizes hypotheses and claims from the Anthropocene concept of Earth System Science that point to humans becoming a geobiophysical force in the Anthropocene. Three areas in which anthropological constants could be subsequently subjected to a deeper analysis are proposed.
--------------------------
Received: 01/12/2022. Reviewed: 08/02/2023. Accepted: 30/03/2023.
Natural Products: A Potential New Hope to Defeat Post-acute Sequelae of
COVID-19
Authors: Zhao Shuang , Abdurehim Aliya , Yuan Yu , Yang Tan , Li Chao , Zhang Yanqing , Li Yaxin , Sun Xiuyan , Xie Junbo 
Published: August 2023

Abstract:
The COVID-19 pandemic was the most significant public healthcare crisis worldwide. It was estimated that 80% of infected patients with COVID-19 have not fully recovered and devel-oped one or more long-term symptoms, referred to as post-acute sequelae of COVID-19 (PASC). Seeking a treatment strategy for PASC has become a concerning topic since the sequelae can cause irreversible multiple organ damage and can severely compromise quality of life. It is indicated that PASC may be closely related to lung injury-induced hypoxia, excessive immune response, cytokine storm, gut bacteria imbalance, and endothelial dysfunction. Also, more and more research has indi-cated that angiotensin-converting enzyme 2 (ACE2) receptor, transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1), and nuclear factor erythroid 2-related factor 2 (Nrf2) can be considered as the targets to treat PASC. There is currently still no proven medication for PASC due to its com-plexity. Many clinical practices and studies have shown that natural products have great potential in preventing and treating PASC. Therefore, we intended to provide a comprehensive review of the current literature on PASC and the role of natural ingredients in PASC management. Meanwhile, this review provided meaningful insight for further study of natural ingredients to improve PASC and its clinical application.
Fabrication of Graphene-based Ammonia Sensors: A Review
Authors: Xu Ke , Zheng Wei 
Published: August 2023

Abstract:
Graphene gas sensors have gained much scientific interest due to their high sensitivity,
selectivity, and fast detection of various gases. This article summarizes the research progress
of graphene gas sensors for detecting ammonia gas at room temperature. Firstly, the performance
and development trends of the graphene/semiconductor Schottky diode sensor are discussed.
Secondly, manufacturing methods and the latest developments in graphene field-effect
transistor sensors are reviewed. Finally, the basic challenges and latest efforts of functional ammonia
gas sensors are studied. The discussion delves into each sensor type's detection principles
and performance indicators, including selectivity, stability, measurement range, response time,
recovery time, and relative humidity. A comparative analysis is conducted to highlight the progress
achieved in research, elucidating the advantages, disadvantages, and potential solutions
associated with various sensors. As a result, the paper concludes by exploring the future development
prospects of graphene-based ammonia sensors.
An Investigation of the Relationship Between 18F-FDG PET/CT Parameters
of Primary Tumors and Lymph Node Metastasis in Resectable Non-small
Cell Lung Cancer
Authors: Kandemir Ozan , Demir Fadime 
Published: August 2023

Background:
Mediastinal lymph node metastasis is an important prognostic factor in
non-small cell lung cancer (NSCLC) patients without distant metastases. 18F-2-fluoro-2-deoxy-Dglucose
Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) is recommended
for detecting and staging lymph nodes and distant metastases in NSCLC patients.

Objective:
This study aims to investigate whether maximum standardized uptake (SUVmax),
mean standardized uptake (SUVmean), metabolic tumor volume (MTV), and tumor lesion glycolysis
(TLG) values of the primary tumor measured by 18F-FDG PET/CT in resectable NSCLC can
predict preoperative lymph node metastasis.

Methods:
This retrospective study included eighty NSCLC patients who underwent preoperative
Positron Emission Tomography/Computed Tomography (PET/CT) for diagnosis and staging. The
patients were stage I-III and had no distant metastases. Tumor metabolic parameters such as SUVmax,
SUVmean, MTV, and TLG at PET/CT imaging were measured for preoperative diagnosis
and staging, and the postoperative pathology results of the patients were examined. The pathology
results divided patients with and without lymph node metastasis into two groups. The groups were
compared with the student's t-test and chi-square test regarding 18F-FDG PET/CT tumor metabolic
parameters and other parameters.

Results:
Fifteen (18.8%) patients were female, and 65 (81.3%) were male. According to the postoperative
pathology results, while 30 (37.5%) patients had lymph node metastasis, 50 (62.5%) did
not. There was a significant difference between the groups regarding tumor SUVmax and SUVmean
values (p = 0.036, p = 0.045). Overall survival in the N0 group was significantly higher
than in the N1 + N2 group (p = 0.034); median survival was 30.2 months in N0 cases and 27.3
months in N1 and N2 groups.

Conclusion:
SUVmax and SUVmean values are significantly higher in patients with lymph node
metastases than in patients without lymph node metastases, and this finding may provide useful
information for predicting lymph node metastasis in patients with resectable NSCLC.
Establishment of a Public Mental Health Database for Research Purposes in the Ferrara Province: Development and Preliminary Evaluation Study
Authors: Ferrara Maria , Gentili Elisabetta , Belvederi Murri Martino , Zese Riccardo , Alberti Marco , Franchini Giorgia , Domenicano Ilaria , Folesani Federica , Sorio Cristina , Benini Lorenzo , Carozza Paola , Little Julian , Grassi Luigi 
Published: August 2023

AbstractBackgroundThe immediate use of data exported from electronic health records (EHRs) for research is often limited by the necessity to transform data elements into an actual data set.ObjectiveThis paper describes the methodology for establishing a data set that originated from an EHR registry that included clinical, health service, and sociodemographic information.MethodsThe Extract, Transform, Load process was applied to raw data collected at the Integrated Department of Mental Health and Pathological Addictions in Ferrara, Italy, from 1925 to February 18, 2021, to build the new, anonymized Ferrara-Psychiatry (FEPSY) database. Information collected before the first EHR was implemented (ie, in 1991) was excluded. An unsupervised cluster analysis was performed to identify patient subgroups to support the proof of concept.ResultsThe FEPSY database included 3,861,432 records on 46,222 patients. Since 1991, each year, a median of 1404 (IQR 1117.5-1757.7) patients had newly accessed care, and a median of 7300 (IQR 6109.5-9397.5) patients were actively receiving care. Among 38,022 patients with a mental disorder, 2 clusters were identified; the first predominantly included male patients who were aged 25 to 34 years at first presentation and were living with their parents, and the second predominantly included female patients who were aged 35 to 44 years and were living with their own families.ConclusionsThe process for building the FEPSY database proved to be robust and replicable with similar health care data, even when they were not originally conceived for research purposes. The FEPSY database will enable future in-depth analyses regarding the epidemiology and social determinants of mental disorders, access to mental health care, and resource utilization.
Effectiveness of the Wellness Together Canada Portal as a Digital Mental Health Intervention in Canada: Protocol for a Randomized Controlled Trial
Authors: Basnet Syaron , Chaiton Michael 
Published: August 2023

Background
The Wellness Together Canada (WTC) portal is a digital mental health intervention that was developed in response to an unprecedented rise in mental health and substance use concerns due to the COVID-19 pandemic, with funding from the Government of Canada. It is a mental health and substance use website to support people across Canada providing digital interventions and services at no cost. Two million people have visited the WTC portal over the course of 1 year since launching; however, rigorous evaluation of this potential solution to access to mental health care during and after the COVID-19 pandemic is urgently required.

Objective
This study aims to better understand the effectiveness of the existing digital interventions in improving population mental health in Canada.

Methods
The Let’s Act on Mental Health study is designed as a longitudinal fully remote, equally randomized (1:1), double-blind, alternative intervention–controlled, parallel-group randomized controlled trial to be conducted between October 2023 and April 2024 with a prospective follow-up study period of 26 weeks. This trial will evaluate whether a digital intervention such as the WTC improves population mental health trajectories over time.

Results
The study was approved by the research ethics board of CAMH (Centre for Addiction and Mental Health, Toronto, Ontario, Canada). It is ongoing and participant recruitment is underway. As of August 2023, a total of 453 participants in the age group of 18-72 years have participated, of whom 70% (n=359) are female.

Conclusions
This initiative provides a unique opportunity to match people’s specific unmet mental health and substance use needs to evidence-based digital interventions.