bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal management of patients after acute coronary syndrome
Authors: Panattoni Germana , Monzo Luca , Gugliotta Maria , Proietti Giulia , Tatangelo Mario , Jacomelli Ilaria , Zimbardo Giuseppe , Meringolo Federica , Fedele Elisa , Calò Leonardo 
Published: April 2023

Abstract
Patients with clinically established atherosclerotic cardiovascular disease are at a very high risk of recurrent cardiovascular events. An adequate management of risk factors and the implementation of healthy behaviours significantly decrease the risk of unfavourable clinical outcomes and future cardiovascular events, including death. Patients discharged after an acute coronary syndrome should be managed according to their individual risk level in order to ensure the appropriate treatment. Nevertheless, care pathways should also take into consideration the available resources and the logistical/structural aspects. In this setting, cardiac rehabilitation is prosed as a multidisciplinary approach to improving daily function and reducing cardiovascular risk factors. The organization of a network with the involvement of different medical and non-medical figures is essential to ensure successful outcomes and expected cost-effectiveness.
The electrocardiogram in non-ischaemic-dilated cardiomyopathy
Authors: Crescenzi Cinzia , Silvetti Elisa , Romeo Fabiana , Martino Annamaria , Bressi Edoardo , Panattoni Germana , Stefanini Matteo , Stazi Alessandra , Danza Maria Ludovica , Rebecchi Marco , Canestrelli Stefano , Fedele Elisa , Lanza Oreste , Lanzillo Chiara , Fusco Armando , Golia Paolo , De Ruvo Ermenegildo , Calò Leonardo 
Published: April 2023

Abstract
This article summarizes the main electrocardiogram (ECG) findings in dilated cardiomyopathy (DCM) patients. Recent reports are described in the great ‘pot’ of DCM peculiar ECG patterns that are typical of specific forms of DCM. Patients with late gadolinium enhancement on CMR, who are at greatest arrhythmic risk, have also distinctive ECG features. Future studies in large DCM populations should evaluate the diagnostic and prognostic value of the ECG.
Cardiac magnetic resonance in Fabry disease
Authors: Lanzillo Chiara , Fedele Elisa , Martino Annamaria , Ferrazza Alessandro , Fusco Armando , Silvetti Elisa , Canestrelli Stefano , Romeo Fabiana , Canali Emanuele , De Luca Lucia , Golia Paolo , Crescenzi Cinzia , Stefanini Matteo , Calò Leonardo 
Published: April 2023

Abstract
Fabry disease (FD) is a rare X-linked inherited lysosomal storage disorder caused by deficient a-galactosidase A activity that leads to an accumulation of glycolipids, mainly globotriaosylceramide (Gb3) and globotriaosylsphingosine, in affected tissues, including the heart. Cardiovascular involvement usually manifests as left ventricular hypertrophy (LVH), myocardial fibrosis, heart failure, and arrhythmias, which limit the quality of life and represent the most common causes of death. Following the introduction of enzyme replacement therapy, early diagnosis and treatment have become essential in slowing down the disease progression and preventing major cardiac complications. Recent advances in the understanding of FD pathophysiology suggest that in addition to Gb3 accumulation, other mechanisms contribute to the development of cardiac damage. FD cardiomyopathy is characterized by an earlier stage of glycosphingolipid accumulation and a later one of hypertrophy. Morphological and functional aspects are not specific in the echocardiographic evaluation of Anderson–Fabry disease. Cardiac magnetic resonance with tissue characterization capability is an accurate technique for the differential diagnosis of LVH. Progress in imaging techniques has improved the diagnosis and staging of FD-related cardiac disease: a decreased myocardial T1 value is specific of FD. Late gadolinium enhancement is typical of the later stage of cardiac involvement but as in other cardiomyopathy is also valuable to predict the outcome and cardiac response to therapy.
How an innovative catheter with temperature control and very high-power, short-duration ablation changed our approach to the treatment of persistent atrial fibrillation
Authors: Volpato Giovanni , Compagnucci Paolo , Cipolletta Laura , Parisi Quintino , Valeri Yari , Santarelli Giulia , Colonnelli Michela , Casella Michela , Dello Russo Antonio 
Published: April 2023

Abstract
Ablation targets of persistent atrial fibrillation remain poorly understood nowadays: due to structural alterations of the left atrium, isolation of the pulmonary veins alone has proved ineffective. New ablation targets such as the posterior wall, coronary sinus, and left atrial appendage were then sought. A new catheter (QDOT Micro™) has recently been released, which has the potential to increase the safety and efficacy of the procedure: it is connected to a new radiofrequency generator that allows for temperature-controlled ablation by reducing power and increasing irrigation with the increase in tissue temperature and allows to deliver power up to 90 W for few seconds (very high-power short-duration).
Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2
Authors: Giannetti Federica , Barbieri Miriam , Shiti Assad , Casini Simona , Sager Philip T , Das Saumya , Pradhananga Sabindra , Srinivasan Dinesh , Nimani Saranda , Alerni Nicolò , Louradour Julien , Mura Manuela , Gnecchi Massimiliano , Brink Paul , Zehender Manfred , Koren Gideon , Zaza Antonio , Crotti Lia , Wilde Arthur A M , Schwartz Peter J , Remme Carol Ann , Gepstein Lior , Sala Luca , Odening Katja E 
Published: April 2023

Abstract

Aims
Current long QT syndrome (LQTS) therapy, largely based on beta-blockade, does not prevent arrhythmias in all patients; therefore, novel therapies are warranted. Pharmacological inhibition of the serum/glucocorticoid-regulated kinase 1 (SGK1-Inh) has been shown to shorten action potential duration (APD) in LQTS type 3. We aimed to investigate whether SGK1-Inh could similarly shorten APD in LQTS types 1 and 2.

Methods and results
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and hiPSC-cardiac cell sheets (CCS) were obtained from LQT1 and LQT2 patients; CMs were isolated from transgenic LQT1, LQT2, and wild-type (WT) rabbits. Serum/glucocorticoid-regulated kinase 1 inhibition effects (300 nM–10 µM) on field potential durations (FPD) were investigated in hiPSC-CMs with multielectrode arrays; optical mapping was performed in LQT2 CCS. Whole-cell and perforated patch clamp recordings were performed in isolated LQT1, LQT2, and WT rabbit CMs to investigate SGK1-Inh (3 µM) effects on APD. In all LQT2 models across different species (hiPSC-CMs, hiPSC-CCS, and rabbit CMs) and independent of the disease-causing variant (KCNH2-p.A561V/p.A614V/p.G628S/IVS9-28A/G), SGK1-Inh dose-dependently shortened FPD/APD at 0.3–10 µM (by 20–32%/25–30%/44–45%). Importantly, in LQT2 rabbit CMs, 3 µM SGK1-Inh normalized APD to its WT value. A significant FPD shortening was observed in KCNQ1-p.R594Q hiPSC-CMs at 1/3/10 µM (by 19/26/35%) and in KCNQ1-p.A341V hiPSC-CMs at 10 µM (by 29%). No SGK1-Inh-induced FPD/APD shortening effect was observed in LQT1 KCNQ1-p.A341V hiPSC-CMs or KCNQ1-p.Y315S rabbit CMs at 0.3–3 µM.

Conclusion
A robust SGK1-Inh-induced APD shortening was observed across different LQT2 models, species, and genetic variants but less consistently in LQT1 models. This suggests a genotype- and variant-specific beneficial effect of this novel therapeutic approach in LQTS.
Plastic responses to warmer climates: a semi-natural experiment on lizard populations
Authors: Bestion Elvire , San-Jose Luis M , Di Gesu Lucie , Richard Murielle , Sinervo Barry , Côte Jessica , Calvez Olivier , Guillaume Olivier , Cote Julien 
Published: April 2023

Abstract
Facing warming environments, species can exhibit plastic or microevolutionary changes in their thermal physiology to adapt to novel climates. Here, using semi-natural mesocosms, we experimentally investigated over two successive years whether a 2°C-warmer climate produces selective and inter- and intragenerational plastic changes in the thermal traits (preferred temperature and dorsal coloration) of the lizard Zootoca vivipara. In a warmer climate, the dorsal darkness, dorsal contrast, and preferred temperature of adults plastically decreased and covariances between these traits were disrupted. While selection gradients were overall weak, selection gradients for darkness were slightly different between climates and in the opposite direction to plastic changes. Contrary to adults, male juveniles were darker in warmer climates either through plasticity or selection and this effect was strengthened by intergenerational plasticity when juveniles’ mothers also experienced warmer climates. While the plastic changes in adult thermal traits alleviate the immediate overheating costs of warming, its opposite direction to selective gradients and to juveniles’ phenotypic responses may slow down evolutionary shifts toward phenotypes that are better adapted to future climates. Our study demonstrates the importance of considering inter- and intragenerational plasticity along with selective processes to better understand adaptation and population dynamics in light of climate change.
Need a flu jab? Let’s try pharmacy: patient characteristics and experiences with pharmacy immunisation services
Authors: Dalgado Amanda , Patel Jatin , Kim Jenny , Helm Kara , Williams Kate , Kadariya Kubir , Napier Patti , Anwar Mudassir 
Published: April 2023

Abstract

Objectives
New Zealand pharmacists have been providing immunisation services since 2011. Literature from other developed countries reports the positive experience of people with community pharmacy immunisation services resulting in expansion of the scope of pharmacy practice. However, there is a dearth of such data in a New Zealand context. Therefore, we aimed to understand patients’ experiences with pharmacy immunisation services in New Zealand.

Methods
A self-administered questionnaire developed after considering the aims and objectives of the study, and previously published literature was delivered to 14 pharmacies covering a range of socio-economic areas across New Zealand. The survey assessed patients’ experiences in a community pharmacy setting and measured their satisfaction using a 5-point Likert scale.

Key findings
Out of the 364 survey participants, 60.7% were female, 76.9% were of European ethnicity and 43.4% belonged to the age group of 45–64 years. Convenience (65.4%) and accessibility (44.8%) were cited as the most common reasons for choosing a community pharmacy to receive vaccinations. Over 90% of the respondents reported that they were satisfied with the pharmacy immunisation services, were vaccinated professionally, would choose a community pharmacy again next time for vaccination and would like to see pharmacists administering other vaccines.

Conclusions
The pharmacy immunisation services were highly valued by patients because of the associated convenience and professionalism demonstrated by the pharmacists. A possible expansion of pharmacist-administered vaccination services to a wider range of vaccines will not only improve access to immunisation but will also potentially escalate immunisation rates.
In Vivo Study of the Effects of Propranolol, Timolol, and Minoxidil on Burn Wound Healing in Wistar Rats
Authors: Freiha Michel , Achim Marcela , Gheban Bogdan-Alexandru , Moldovan Remus , Filip Gabriela Adriana 
Published: April 2023

Abstract
Propranolol, timolol, and minoxidil have all shown benefits in treatment of burn injury and other skin wounds. The study evaluated their effects on full-thickness thermal skin burns in a Wistar rat model.
Performed on 50 female rats; two dorsal skin burns were created on each animal. On the next day, the rats were divided into 5 groups (n = 10); each has received a specific treatment daily for 14 days: group I—topical vehicle (control), group II—topical silver sulfadiazine (SSD), group III—oral propranolol (5.5 mg) associated with topical vehicle, group IV—topical timolol 1% cream, and group V—topical minoxidil 5% cream. Wound contraction rates, malondialdehyde (MDA), glutathione (GSH, GSSG), and catalase activity in skin and/or serum were evaluated, and histopathological analyses were performed.
Propranolol did not show advantages in necrosis prevention and wound contraction and healing, and did not reduce oxidative stress. It impaired keratinocyte migration, and promoted ulceration, chronic inflammation, and fibrosis, yet reducing the necrotic zone. Timolol prevented necrosis and promoted contraction and healing, increased antioxidant capacity and promoted keratinocyte migration and neo capillarization in comparison to the other treatments. Minoxidil reduced necrosis and enhanced contraction, resulting in positive outcomes after 1 week of treatment regarding local antioxidant defense, keratinocyte migration, neo capillarization, chronic inflammation, and fibrosis rates. However, after 2 weeks, it resulted in contrasting outcomes.
In conclusion, topical timolol promoted wound contraction and healing, reducing local oxidative stress and improving keratinocyte migration, bringing arguments for potential benefits in skin epithelization.
Life form-dependent nitrogen–phosphorous allocation strategies of leaf and fine root in a temperate natural forest under long-term nitrogen addition
Authors: Yu Jiangshan , Song Zhaopeng , Hou Jihua 
Published: April 2023

Abstract
Nitrogen deposition has increased rapidly in eastern China, which can affect the stoichiometric characteristics of plants. However, the effects of N addition on the nitrogen (N) and phosphorous (P) allocation strategies for various plant life forms (e.g. trees, shrubs and herbs) have rarely been studied. In this study, we evaluated the effects of N addition on N and P stoichiometry and their scaling exponents in the leaves and fine roots of the different life form groups. N and P concentrations in the leaves of shrubs and herbs increased under N addition treatments, whereas tree leaves exhibited a more stable response. In contrast, N addition had no significant effect on N and P concentrations in the fine roots of the three plant life forms. N addition enhanced the allocation of more N and P to the leaves than to the fine roots in all three life forms. Furthermore, the N–P allocation scaling exponents of the leaves and fine roots of the trees were equal to 1.0, indicating an isometric pattern. In contrast, the N–P allocation scaling exponents of shrubs and herbs were less than 1.0, indicating an allometric pattern. Although high N availability promoted shrubs and herbs to distribute P to leaves at a higher proportion than N, only slight effects were detected in tree leaves. These changes in N–P allocation patterns indicate that life forms and N addition levels work together to modulate plants allocation strategies. These results suggest the importance of life form categories when evaluating N–P allocation strategies in forest plants.
The Burden of Human Bocavirus 1 in Hospitalized Children With Respiratory Tract Infections
Authors: Jalving Hedda Trømborg , Heimdal Inger , Valand Jonas , Risnes Kari , Krokstad Sidsel , Nordbø Svein Arne , Døllner Henrik , Christensen Andreas 
Published: April 2023

Abstract

Background
Human bocavirus 1 (HBoV1) is frequently codetected with other viruses, and detected in asymptomatic children. Thus, the burden of HBoV1 respiratory tract infections (RTI) has been unknown. Using HBoV1-mRNA to indicate true HBoV1 RTI, we assessed the burden of HBoV1 in hospitalized children and the impact of viral codetections, compared with respiratory syncytial virus (RSV).

Methods
Over 11 years, we enrolled 4879 children &lt;16 years old admitted with RTI. Nasopharyngeal aspirates were analyzed with polymerase chain reaction for HBoV1-DNA, HBoV1-mRNA, and 19 other pathogens.

Results
HBoV1-mRNA was detected in 2.7% (130/4850) samples, modestly peaking in autumn and winter. Forty-three percent with HBoV1 mRNA were 12–17 months old, and only 5% were &lt;6 months old. A total of 73.8% had viral codetections. It was more likely to detect HBoV1-mRNA if HBoV1-DNA was detected alone (odds ratio [OR]: 3.9, 95% confidence interval [CI]: 1.7–8.9) or with 1 viral codetection (OR: 1.9, 95% CI: 1.1–3.3), compared to ≥2 codetections. Codetection of severe viruses like RSV had lower odds for HBoV1-mRNA (OR: 0.34, 95% CI: 0.19–0.61). The yearly lower RTI hospitalization rate per 1000 children &lt;5 years was 0.7 for HBoV1-mRNA and 8.7 for RSV.

Conclusions
True HBoV1 RTI is most likely when HBoV1-DNA is detected alone, or with 1 codetected virus. Hospitalization due to HBoV1 LRTI is 10–12 times less common than RSV.
Peeking beneath the precision floor − II. Probing the chemo-dynamical histories of the potential globular cluster siblings, NGC 288 and NGC 362
Authors: Monty Stephanie , Yong David , Massari Davide , McKenzie Madeleine , Myeong GyuChul , Buder Sven , Karakas Amanda I , Freeman Ken C , Marino Anna F , Belokurov Vasily , Evans N Wyn 
Published: April 2023

ABSTRACT
The assembly history of the Milky Way (MW) is a rapidly evolving subject, with numerous small accretion events and at least one major merger proposed in the MW’s history. Accreted alongside these dwarf galaxies are globular clusters (GCs), which act as spatially coherent remnants of these past events. Using high precision differential abundance measurements from our recently published study, we investigate the likelihood that the MW clusters NGC 362 and NGC 288 are galactic siblings, accreted as part of the Gaia-Sausage-Enceladus (GSE) merger. To do this, we compare the two GCs at the 0.01 dex level for 20 + elements for the first time. Strong similarities are found, with the two showing chemical similarity on the same order as those seen between the three LMC GCs, NGC 1786, NGC 2210-, and NGC 2257. However, when comparing GC abundances directly to GSE stars, marked differences are observed. NGC 362 shows good agreement with GSE stars in the ratio of Eu to Mg and Si, as well as a clear dominance in the r- compared to the s-process, while NGC 288 exhibits only a slight r-process dominance. When fitting the two GC abundances with a GSE-like galactic chemical evolution model, NGC 362 shows agreement with both the model predictions and GSE abundance ratios (considering Si, Ni, Ba, and Eu) at the same metallicity. This is not the case for NGC 288. We propose that the two are either not galactic siblings, or GSE was chemically inhomogeneous enough to birth two similar, but not identical clusters with distinct chemistry relative to constituent stars.
Social determinants of cognitive outcomes in survivors of pediatric brain tumors treated with conformal radiation therapy
Authors: Mule' Taylor N , Hodges Jason , Wu Shengjie , Li Yimei , Ashford Jason M , Merchant Thomas E , Conklin Heather M 
Published: April 2023

Abstract

Background
Social determinants of health including parental occupation, household income, and neighborhood environment are predictors of cognitive outcomes among healthy and ill children; however, few pediatric oncology studies have investigated this relationship. This study utilized the Economic Hardship Index (EHI) to measure neighborhood-level social and economic conditions to predict cognitive outcomes among children treated for brain tumors (BT) with conformal radiation therapy (RT).

Methods
Two hundred and forty-one children treated on a prospective, longitudinal, phase II trial of conformal photon RT (54–59.4 Gy) for ependymoma, low-grade glioma, or craniopharyngioma (52% female, 79% white, age at RT = 7.76 ± 4.98 years) completed serial cognitive assessments (intelligence quotient [IQ], reading, math, and adaptive functioning) for ten years. Six US census tract-level EHI scores were calculated for an overall EHI score: unemployment, dependency, education, income, crowded housing, and poverty. Established socioeconomic status (SES) measures from the extant literature were also derived.

Results
Correlations and non-parametric tests revealed EHI variables share modest variance with other SES measures. Income, unemployment, and poverty overlapped most with individual SES measures. Linear mixed models, accounting for sex, age at RT, and tumor location, revealed EHI variables predicted all cognitive variables at baseline and change in IQ and math over time, with EHI overall and poverty most consistent predictors. Higher economic hardship was associated with lower cognitive scores.

Conclusions
Neighborhood-level measures of socioeconomic conditions can help inform understanding of long-term cognitive and academic outcomes in survivors of pediatric BT. Future investigation of poverty’s driving forces and the impact of economic hardship on children with other catastrophic diseases is needed.
Kondo scattering in underdoped Nd1−xSrxNiO2 infinite-layer superconducting thin films
Authors: Shao Ting-Na , Zhang Zi-Tao , Qiao Yu-Jie , Zhao Qiang , Liu Hai-Wen , Chen Xin-Xiang , Jiang Wei-Min , Yao Chun-Li , Chen Xing-Yu , Chen Mei-Hui , Dou Rui-Fen , Xiong Chang-Min , Zhang Guang-Ming , Yang Yi-Feng , Nie Jia-Cai 
Published: April 2023

ABSTRACT
The recent discovery of superconductivity in infinite-layer nickelates generates tremendous research endeavors, but the ground state of their parent compounds is still under debate. Here, we report experimental evidence for the dominant role of Kondo scattering in the underdoped Nd1−xSrxNiO2 thin films. A resistivity minimum associated with logarithmic temperature dependence in both longitudinal and Hall resistivities are observed in the underdoped Nd1−xSrxNiO2 samples before the superconducting transition. At lower temperatures down to 0.04 K, the resistivities become saturated, following the prediction of the Kondo model. A linear scaling behavior $\sigma _{{\boldsymbol{xy}}}^{{{\bf AHE}}}{\rm{\ }}\sim{\rm{\ }}{\sigma }_{{\boldsymbol{xx}}}$ between anomalous Hall conductivity $\sigma _{{\boldsymbol{xy}}}^{{\bf{AHE}}}$ and conductivity ${\sigma }_{{\boldsymbol{xx}}}{\rm{\ }}$is revealed, verifying the dominant Kondo scattering at low temperature. The effect of weak (anti-)localization is found to be secondary. Our experiments can help in clarifying the basic physics in the underdoped Nd1−xSrxNiO2 infinite-layer thin films.