bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferroptosis Related Prediction Model for Hepatocellular Carcinoma Patients Sensitive to Chemotherapy Embolization Therapy Based on Bioinformatics Analysis
Authors: Rui Jiang , Zhengli Liu , Guanqi Fu , Boxiang Zhao , Maofeng Gong , Zhaoxuan Lu , Yangyi Zhou , Liang Chen , Haobo Su , Wensheng Lou , Guoping Chen , Jie Kong , Jianping Gu , Xu He 
Published: June 2023

Abstract
Objective: The objective of this study was to develop a predictive model that can help with effective transcatheter arterial chemoembolization (TACE) in treating hepatocellular carcinoma by identifying ferroptosis-associated genes.
Methods: In this study, the GSE104580 dataset from the GEO database was analyzed to identify significantly differentially expressed genes (DEGs), which were then used to identify genes associated with chemoembolization sensitivity and ferroptosis using the weighted gene co-expression network analysis (WGCNA). These genes were then used to construct a TACE treatment sensitivity prediction model using lasso regression. Immune infiltration analysis was also conducted, and a hub mRNA, hub miRNA, and hub lncRNA interaction network was established. The TCGA dataset was used to construct a prediction model which was validated by ICGC dataset.
Results: Using the GSE104580 dataset, a total of 2689 DEGs were screened, resulting in the identification of 37 genes. Protein-protein interaction (PPI) network analysis was performed based on these genes, and key genes involved in predicting TACE treatment sensitivity for liver cancer were identified through GO, KEGG, and GSEA analyses. Using the lasso regression method, six hub genes were identified: GLS2, CDKN1A, GPT2, ASNS, SLC38A1, and SLC2A1. Two distinct ferroptosis patterns were identified based on these hub genes, and immune infiltration analysis was conducted to further investigate potential associations with liver cancer. Additionally, a hub mRNA, miRNA, and LncRNA interaction network was constructed using data from miRTarBase, TarBase, and Starbase databases. Utilizing a 6-gene signature, two distinct risk groups were identified. Remarkably, patients classified within the high-risk group exhibited a significant decrease in overall survival when compared to their low-risk counterparts (P < 0.001 in the TCGA cohort and P = 0.013 in the ICGC cohort). In addition, the predictive capacity of this signature was further validated by receiver operating characteristic (ROC) curve analysis.
Conclusion: This study suggests that the six hub genes identified in this research could serve as important targets for improving liver cancer prognosis. Additionally, these genes can be utilized to construct effective TACE sensitive prediction models to help clinicians in treating hepatocellular carcinoma.
Differential regulatory control of curli (csg) gene expression in Salmonella enterica serovar Typhi required more than a functional CsgD regulator
Authors: Ou Camille , Dozois Charles M. , Daigle France 
Published: June 2023

Abstract
The human-specific Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a systemic disease with no known reservoir. Curli fimbriae are major components of biofilm produced by Salmonella and are encoded by the csg gene cluster (csgBAC and csgDEFG). The role of curli in S. Typhi is unknown, although detection of anti-curli antibodies suggests they are produced during host infection. In this study, we investigated curli gene expression in S. Typhi. We demonstrated that the CsgD regulatory protein bounds weakly to the csgB promoter. Yet, replacing S. Typhi csgD with the csgD allele from S. Typhimurium did not modify the curli negative phenotype on Congo Red plate suggesting that differential regulation of curli gene expression in S. Typhi is not dependent on modification of the CsgD regulator. The entire csg gene cluster from S. Typhimurium was also cloned into S. Typhi, but again, despite introduction of a fully functional csg gene cluster from S. Typhimurium, curli were still not detected in S. Typhi. Thus, in addition to intrinsic genomic differences in the csg gene cluster that have resulted in production of a modified CsgD protein, S. Typhi has likely undergone other changes independent of the csg gene cluster that have led to distinctive regulation of csg genes compared to others Salmonella serovars.
Research on the influence of collective nostalgia on the purchase intention of time-honored brand products
Authors: Zhang Yi , tao wenxia 
Published: June 2023

Abstract
Individual nostalgia has an important influence on purchase decision, but the influence mechanism of collective nostalgia on purchase decision is not clear. This paper constructs a conceptual model on the basis of the literature. Collective nostalgia affects the purchase intention of time-honored brand products through two paths: perceived quality, perceived value and self-concept connection. In this paper, 276 respondents with collective nostalgia were collected. The empirical results show that collective nostalgia can directly predict the purchase intention of time-honored brand products, and can positively predict the purchase intention of time-honored brand products through the chain mediating effect of perceived quality and perceived value. Self-concept connection also plays a mediating role between collective nostalgia and purchase intention of time-honored brand products. This study extends the individual dimension of nostalgia to the collective dimension, verifies the mechanism of collective nostalgia on purchase intention, and has a certain practical significance for the emotional marketing of time-honored brand products.
The INSIGHT project: A Quality Recognition Programme to showcase excellence in public involvement in health and social care research
Authors: Blackburn Steven , Hine Rachele , Fairbanks Samantha , Parkes Phillip , Murinas Darren , Meakin Andrew , Taylor Robert , Parton Linda , Jones Marilyn , Tunmore Jessica , Lench Jennifer , Evans Nicola , Lewney Katharine , O’Mara Lucy , A Fryer Anthony 
Published: June 2023

Abstract
Background:
The quality of Public and Patient Involvement (PPI) in healthcare research varies considerably and is frequently tokenistic. We aimed to co-produce the Insight | Public Involvement Quality Recognition and Awards programme, based on the UK Standards for Public Involvement (UKSPI) alongside an incremental scale designed by Expert Citizens (a lived experience-led community group), to incentivise and celebrate continuous improvement in PPI.
Methods:
We used Task and Finish Groups (19/44 [43%] public contributor membership) to co-produce the programme which we piloted in three organisations with different healthcare research models. We used surveys and review sessions to capture learning and reflections.
Results:
We co-created:
(i) a quality descriptor matrix comprising four incremental quality levels (Welcoming, Listening, Learning, Leading) for each UKSPI standard
(ii) an assessment framework including guidance materials, self-assessment form and final report template
(iii) an assessor training package
(iv) the quality awards event format and nomination form. These materials were modified based on pilot-site feedback.
Of survey respondents: 94.4% felt they had made at least ‘Some’ personal contribution (half said ‘Quite a lot’/‘A great deal’), 88.9% said they were ‘Always’/‘Often’ able to express their views freely and, 100% stated the programme would have ‘A lot of impact’/‘Quite a bit of impact’.
During the project, we identified the importance of taking time to explain project aims and contributor roles, adapting to the needs of individual contributors and, using smaller bespoke sessions outside the main Task and Finish Groups.
Conclusions:
We co-produced and piloted a quality recognition programme to incentivise and celebrate continuous quality improvement in PPI. One public contributor stated, “I feel strongly that the Insight framework and awards will raise awareness of the [public involvement]work going on in many community settings. [It] is likely to result in better sharing of positive practice, incentivising research groups of any size to start work or to improve the quality of [PPI] could be one of the main benefits. I’m excited that if this initiative takes off, regionally and then in the longer term nationally, it could be a significant step in advancing the [public] voice.”
Insights into Molecular Evolution of Enterovirus D68
Authors: Wolf Jonas 
Published: June 2023

Abstract
Enterovirus D68 (EV-D68) is a respiratory virus that primarily affects children and has been associated with sporadic outbreaks of respiratory illness worldwide. The present study evaluated temporal spreading and molecular evolution of EV-D68 clades (A1, A2, B, B1, B2, B3, and C). Bayesian coalescent analyses was performed to study viral evolution. Data from 976 whole genome sequences (WGS) collected between 1977 to 2022 were evaluated. The time to the most recent common ancestor of A1 was 2005-04-17 in the USA, A2 was 2003-12-23 in China, B was 2003-07-06 in China, B1 was 2010-03-21 in Vietnam, B2 was 2006-11-25 in Vietnam, B3 was 2011-01-15 in China, and C was 2000-06-27 in the USA. The molecular origin of the EV-D68 was in Canada in 1995, later it was disseminated in France in 1997, the USA in 1999, Asia in 2008, the Netherlands in 2009, New Zealand in 2010, Mexico in 2014, Kenya in 2015, Sweden in 2016, Switzerland in 2018, Spain in 2018, Belgium in 2018, Australia in 2018, and Denmark in 2019. Recently, in 2022 this virus circulated in the USA. In conclusion, EV-D68 was originated in Canada in 1995 and spread to Europe, Asia, Oceania, Latin America, and Africa.
Prognostic Risk Prediction of Bladder Cancer Patients Regarding the Tumor-Node-Metastasis Staging System and Tumor Infiltration
Authors: Huang Xinmian , Yuan Fang , Li Xiangjie , Hong Chaojin 
Published: June 2023

Abstract
Objective
The clinical stage and pathological grade of bladder tumors are the most valuable parameters to judge the prognosis of bladder tumors. To explore the predictive value of tumor-node-metastasis (TNM) stage and tumor invasion degree on the prognostic risk of bladder cancer (BC) patients,
Methods
90 cases of BC patients were selected as the research objects. Patient age, disease history, tumor metastasis, TNM stage, and tumor differentiation degree (TDD) were collected, and the influencing factors of patient prognosis were analyzed. In addition, the prognosis and urodynamic status of patients with different TNM stages were compared.
Results
ccording to the results of multiple regression analysis, the TDD, hydronephrosis, occurrence of lymph node metastasis (LNM), and TNM stage were independent prognostic factors of BC patients. The operation time of T3 and T4 patients (133.02 ± 9.72 min, 132.18 ± 10.08 min) was substantially longer than that of T1 and T2 patients (126.38 ± 9.41 min, 127.21 ± 10.28 min) (P < 0.05). The maximum urinary flow rates of patients in the T1, T2, T3, and T4 stages were 15.12 ± 1.79 mL/s, 14.18 ± 1.65 mL/s, 12.03 ± 1.87 mL/s, and 11.76 ± 2.01 mL/s, respectively. The maximum urinary velocity of T3 and T4 patients was notably inferior to that of T1 and T2 patients (P < 0.05), and T2 stage was notably inferior to T1 stage (P < 0.05). The residual urine volumes of patients in the T1, T2, T3, and T4 stages were 27.23 ± 6.78 mL, 27.08 ± 6.54 mL, 42.37 ± 7.02 mL, and 47.54 ± 6.69 mL, respectively. The residual urine volume of T3 and T4 patients was markedly superior to that of T1 and T2 patients (P < 0.05), and T4 was markedly superior to T3 (P < 0.05).
Conclusion
In summary, different TNM stages and degrees of tumor invasion had certain effects on the prognosis of BC patients, and the prognosis of patients can be preliminarily predicted and evaluated by tumor TNM stages.
Heatwave vulnerability of large metropolitans in Bangladesh: an evaluation
Authors: Adnan Mohammed Sarfaraz Gani , Kabir Irfat , Hossain Md Alamgir , Enan Muhammad Esmat , Chakma Salit , Tasneem Syeda Nazifa , Hassan Quazi K. , Dewan Ashraf 
Published: June 2023

Abstract
Heatwaves pose a significant risk to human society. Vulnerability to heatwaves is difficult to assess since it depends on a variety of factors, particularly at the local scale. This study aimed at evaluating the heatwave vulnerability of the five major cities of Bangladesh: Chittagong, Dhaka, Khulna, Rajshahi, and Sylhet. A heatwave vulnerability index (HVI) was defined as a function of exposure, sensitivity, and adaptive capacity. Timeseries Moderate Resolution Imaging Spectroradiometer land surface temperature data for 2000–2019 was utilized. The HVI was calculated using a principal component analysis method. The findings of this study indicated that urban centers with a large proportion of built-up areas were more exposed to urban heat than their surroundings. The mean annual LST was highest in Dhaka, the capital, and lowest in Sylhet. Rajshahi and Sylhet had the largest percentage of heat-exposed and sensitive areas, respectively. Sylhet had the highest percentage of heat-vulnerable areas (63%) whereas Dhaka had the highest number of vulnerable people (12.5 million). Increasing urban green and blue infrastructures may help to lessen the negative effects of heatwaves. The methodology and findings of the study could serve as a blueprint for developing heatwave adaptation strategies in Bangladesh, and elsewhere.
Yearly variation of rainfall rate and drop size distribution of RD-80 Disdrometer for Ahmedabad and Thiruvananthapuram
Authors: Shah Nita H. , Shukla Bipasha Paul , Chahal Jyoti 
Published: June 2023

Abstract
The study of the microphysics of precipitation and the development of better rainfall estimation methods heavily rely on studies of the raindrop size distribution (RDSD). This study uses data from the RD-80 Disdrometer collected over three years for Ahmedabad and Thiruvananthapuram (2005–2007). By visualizing the histograms of rainfall bins and calculating the correlation coefficient between rainfall rate and each drop size class of the disdrometer for the monsoon months of June, July, and August, we were able to observe the variability of rainfall year-over-year and month-over-month. The year 2007 appears to have a good link with the greater raindrops for both places, even though the two areas have different characteristics and hence produce different outcomes. Also, except for the year 2005, there is no negative link between rainfall rate and the tiniest droplets in Thiruvananthapuram, which is not the case in Ahmedabad.
A Qualitative Analysis of Algorithm-based Decision Support Usability Testing for Symptom Management Across the Trajectory of Cancer Care: One Size Does Not Fit All
Authors: Yackel Hayley Dunnack , Halpenny Barbara , Abrahm Janet L. , Ligibel Jennifer , Enzinger Andrea , Lobach David F. , Cooley Mary E. 
Published: June 2023

Abstract
Background
Adults with cancer experience symptoms that change across the disease trajectory. Due to the distress and cost associated with uncontrolled symptoms, improving symptom management is an important component of quality cancer care. Clinical decision support (CDS) is a promising strategy to integrate clinical practice guideline (CPG)-based symptom management recommendations at the point of care.
Methods
The objectives of this project were to develop and evaluate the usability of two symptom management algorithms (constipation and fatigue) across the trajectory of cancer care in patients with active disease treated in comprehensive or community cancer care to surveillance of cancer survivors in primary care practice settings. A modified ADAPTE process was used to develop algorithms based on national CPGs. Usability testing involved semi-structured interviews with clinicians from varied care settings, including comprehensive and community cancer centers, and primary care. The transcripts were analyzed with MAXQDA using Braun and Clarke’s thematic analysis method. A cross tabs analysis was also performed to assess the prevalence of themes and subthemes by cancer care setting.
Results
A total of 17 clinicians (physicians, nurse practitioners, and physician assistants) were interviewed for usability testing. Three main themes emerged: 1) Algorithms as useful, 2) Symptom management differences, and 3) Different target end-users. The cross-tabs analysis demonstrated differences among care trajectories and settings that originated in the Symptom management differences theme. The sub-themes of “Differences between diseases” and “Differences between care trajectories” originated from participants working in comprehensive cancer center, which tend to be disease-specific locations for patients on active treatment. Meanwhile, participants from primary care identified the sub-theme of “Differences in settings,” indicating that symptom management strategies are setting specific.
Conclusions
While CDS can help promote evidence-based symptom management, systems providing care recommendations need to be specifically developed to fit patient characteristics and context. Findings suggest that one set of algorithms will not be applicable throughout the entire cancer trajectory. Unique CDS for symptom management will be needed for patients who are cancer survivors being followed in primary care settings.
Breakfast patterns in relation to physical activity among School Adolescents in Karachi, Pakistan
Authors: Ashfaq Mehak Muhammad , Jawed Nida , Safdar Nilofer Fatimi , Bhutto Adnan Ahmed 
Published: June 2023

Abstract
BACKGROUND
Breakfast is an essential meal of the day that plays important role in balanced diet of an individual. Studies have been conducted in developed countries; however, literature is scarce on breakfast consumption patterns among South Asian adolescents. Data about breakfast patterns may help in improving unhealthy breakfast habits and enhance the diet patterns of adolescents.
METHODS
This is a secondary study of a Higher Education Commission-funded project. The research participants, aged 11 to 17, were drawn from lower-middle-income secondary schools using multistage random selection. Socio-demographic and breakfast consumption were determined through interview cum questionnaire and food frequency survey.
RESULTS
The frequency of daily breakfast consumption was 82% among the total participants. 72.2% students considered chapatti as a primary meal for breakfast. Physically active children were less likely to skip breakfast 15.9%, whereas 27.6% were skipping breakfast less physically active group. 11.6% of participants were underweight who skipped breakfast.
CONCLUSIONS
According to the findings, the majority of Pakistani schoolchildren like to have breakfast, though their meal choices do not meet basic standards. Therefore, health promoter’s efforts should aim to counsel parents regarding awareness for healthy breakfast choices.
A cross-sectional study from the National Health and Nutrition Examination Survey reveals the Prognosis and predictors of sarcopenic obesity among cancer patients
Authors: Jiang YiNuo , Yang ChunQian , Zhang Jian , Luo Peng , Jiang WenJie , Wei Ting 
Published: June 2023

Abstract
Objective
Sarcopenic obesity (SO) is a combination of depletion of skeletal muscle mass and obesity, with a high prevalence, undetected onset, challenging diagnosis and poor prognosis. However, studies on SO in cancer settings are limited. We aimed to investigate the association of SO with mortality in cancer patients and the potential predictors involved in the development of SO.
Methods
1344 cancer patients' data from the National Health and Nutrition Examination Survey (NHANES) from the years 1999 to 2006 and 2011 to 2014 were examined. Univariable and multivariable Cox proportional hazard models were used to examine the associations of SO with overall mortality, adjusting for potential confounders. Predictive factors of SO were measured using multivariable logistic regression models. Multiple imputation analysis was used to cope with the missing DXA data.
Results
SO was significantly associated with a higher risk of all-cause mortality (adjusted HR 1.20, 95%CI 1.05–1.37) compared with individuals without SO. Insulin resistance (IR) in cancer patients increased the odds of SO by 2.6 times compared to those without IR (adjusted OR = 2.63, p < 0.0001), and those with hypertriglyceridemia (HTG) were 1.4 times more likely to develop SO compared with those without HTG (adjusted OR = 1.40, p < 0.0001). No significant associations between SO and hypercholesterolemia, high LDL, or low HDL levels were found in cancer patients.
Conclusions
This study is the first to figure out the puzzle of what precise predictors are associated with the occurrence of SO in cancer patients. We discovered that SO in cancer settings is significantly associated with IR and HTG, rather than hypercholesterolemia, LDL, HDL cholesterol or sex hormone which were commonly considered. The presence of SO in cancer patients increases the risk of all-cause mortality. In clinical practice, SO may be a potential and promising target for cancer treatment strategies.
A circular economy approach for papermaking residues: production of admixtures for concrete
Authors: Nunes Caio César Zandonadi , de Paula Higor Brandão , Demuner Iara Fontes , de Paula Marcos Oliveira , Pedroti Leonardo Gonçalves , Carvalho Ana Márcia Macedo Ladeira 
Published: June 2023

Abstract

Kraft lignin is a residue of the kraft pulping process that is normally burnt to produce steam and energy. However, given its high availability as the second most abundant biopolymer, a lignin biorefinery is a promising approach to reach a sustainable bioeconomy. Nevertheless, because of lignin’s complex structure, low reactivity and heterogeneity, this is still challenging. The modification of lignin to produce lignosulfonates is a possible use once they have already been validated by the market as plasticizers in concrete mixtures, surfactants, etc. The aim of this work is to produce lignosulfonates from commercial eucalypt kraft lignin and heat-treated lignin by a sulfomethylation reaction and analyze their use as a concrete plasticizer, comparing with a commercial admixture. The produced lignosulfonates presented a higher concentration in sulfur content, once no purification step was employed, but still a significant increase in water solubility from 7.2% to 98.8% when compared to kraft lignin. Cement pastes, fresh and hardened concretes were produced for the evaluation of the plasticizing performance. Fresh concretes were analyzed as to initial consistency (slump test), while the hardened concretes regarding to axial compression strength and the cement pastes as to viscosity. In concentrations of around 2.2% both kraft lignosulfonate and heat-treated lignosulfonate were found to display an increase in the concrete workability of 75 to 95%. Both lignosulfonates were therefore found to be promising once they present the potential to not only reduce water consumption in concrete preparation while maintaining similar resistance, but also improve waste management in kraft mills.
UV accelerated photocatalytic degradation of carbaryl pesticide using nano ZnO
Authors: Ampolu Satheesh , Hanumanthu Usha , Dalai Santhi Priya 
Published: June 2023

Abstract
Nano zinc oxide was synthesized by the wet chemical process using Zinc Nitrate Hexahydrate as a precursor. The synthesized nano ZnO powder was subjected to characterization to know the morphology and physical properties. FTIR analysis was employed for the identification of the functional group, SEM-EDX Analysis was employed to know the morphological structure and size of nanoparticles and elemental confirmation, Transmission Electron Microscopy was employed to determine the particle size and shape of nanoparticles, and X-Ray Diffraction was employed to identify the crystalline structure. Carbaryl pesticide was taken at a fixed concentration of 5 ppm, and 5mg/L of nano ZnO was added as a catalyst and subjected to photodegradation under UV irradiation. It is observed that in 60 minutes 95% of the pesticide was degraded.