bluuebunny/crossref_metadata_2025_split huggingface dataset:
G2PDeep-v2: a web-based deep-learning framework for phenotype prediction and biomarker discovery for all organisms using multi-omics data
Authors: Zeng Shuai , Adusumilli Trinath , Awan Sania Zafar , Imm Manish Sridhar , Xu Dong , Joshi Trupti 
Published: January 2025

Abstract

The G2PDeep-v2 server is a web-based platform powered by deep learning, for phenotype prediction and markers discovery from multi-omics data in any organisms including humans, plants, animals, and viruses. The server provides multiple services for researchers to create deep-learning models through an interactive interface and train these models using an automated hyperparameter tuning algorithm on high-performance computing resources. Users can visualize the results of phenotype and markers predictions and perform Gene Set Enrichment Analysis for the significant markers to provide insights into the molecular mechanisms underlying complex diseases, conditions and other biological phenotypes being studied. The G2PDeep-v2 server is publicly available at https://g2pdeep.org/ and can be utilized for all organisms.
Effects of Various Chemical Activation Agents on the Properties of Activated Carbon Derived from Waste Olive Stones
Authors: Seçkin İsmail Yiğit 
Published: January 2025

Abstract

In this study, six different activated carbons were synthesized from olive stones using various activating agents, including acidic (H3PO4, H2SO4), basic (NaOH, KOH), and neutral (CaCl2, ZnCl2) agents. These agents were used in a two-step pyrolysis process (carbonization-activation) to produce activated carbons. The activation process was carried out with a 1:1 impregnation ratio, 2-hour activation time, and 750°C activation temperature under an inert atmosphere. The effects of the activating agents on the properties of the activated carbons were analyzed using product yield (%), pHpzc, Ftır spectra, elemental analysis, N2 adsorption, Raman spectroscopy, and scanning electron microscopy. The results of the analysis showed that the properties of the activated carbons depended on the classification of the activating agent used. The pHpzc, surface area, and pore volume of the activated carbons were found to be higher for acidic and neutral activating agents compared to basic activating agents. The highest BET surface area was achieved with H2SO4 activation at 532.34 m2/g, and the highest pore volume values were obtained with H2SO4 and CaCl2 activations at 0.97 cm3/g. The findings indicated that the chemical composition of the activating agents is more important than their classification in influencing the properties of activated carbons.
Research on the method of expanding the mineralization data based on generative adversarial networks
Authors: Li Biyi , Kong Chunfang , Xu Kai , Zhao Jie 
Published: January 2025

Abstract

In the domain of mineral resource exploration, a pronounced imbalance often exists between the number of mineralized samples and the number of samples that are found to be non-mineralized. To address this imbalance, this paper proposes an AC-CTGAN method for expanding mineralized samples based on generative adversarial networks, utilising the northeast Guizhou manganese mining area as a case study. The findings of the research demonstrate that the data generated by AC-CTGAN exhibits excellent performance in terms of spatial distribution and bears a strong resemblance to the feature distribution of real data. The average cross-validation accuracy of the prediction model trained using the expanded dataset is improved by 8\%, and the prediction ability of the model is significantly enhanced.
Prognostic Value of Serum TMAO Measurement in Patients with STEMI:
A Systematic Literature Review
Authors: Vakadaris Georgios , Korovesis Theofanis , Balomenakis Charalampos , Papazoglou Andreas S , Papadakos Stavros P , Karniadakis Ioannis , Moysidis Dimitrios V , Arvanitakis Konstantinos , Germanidis Georgios , Brilakis Emmanouil S. , Milkas Anastasios 
Published: January 2025

Background:
Gut microbiota-derived metabolite Trimethylamine-N-oxide (TMAO) is
increasingly recognized as a potential novel prognostic biomarker for cardiovascular disease. Our
research work aimed to investigate the potential utility of TMAO measurement in patients with STelevation
Myocardial Infarction (STEMI).

Methods:
We performed a systematic literature search in PubMed from inception to the 1st of February
2024 to identify all studies examining the association between plasma TMAO levels and disease
complexity or clinical outcomes in STEMI patients.

Results:
A total of eight prospective cohort studies were included, encompassing a total of 2,378
STEMI patients. Three of the studies provided only in-hospital evidence (i.e., increased odds for
more severe coronary artery disease, plaque rupture, and plaque healing in patients with increased
TMAO levels). Four studies examined the long-term prognostic value of TMAO after 10-12 months
of follow-up post-STEMI (i.e., increased risk of adverse cardiovascular events in patients with increased
TMAO levels), while one study provided data for both in-hospital and mid-term prognosis,
indicating that 4-months after STEMI patients with greater TMAO elevation had larger infarct size.

Conclusion:
Higher TMAO levels were associated with a greater prevalence of high-risk coronary
plaque characteristics and worse in-hospital and follow-up outcomes in STEMI patients. Further
study is needed on whether modulating the diet-dependent TMAO levels could improve clinical outcomes
in these patients.

Registration Number:
[(OSF): https://doi.org/10.17605/OSF.IO/WNG8V]
Chronic oral dosing of cannabidiol and cannabidiolic acid full-spectrum hemp oil extracts has no adverse effects in horses: a pharmacokinetic and safety study
Authors: Wang Tongxin Charlotte , Wakshlag Joseph J. , Jager Mason C. , Schwark Wayne S. , Trottier Nathalie L. , Chevalier Jacqueline M. , Pearson Garett , Cercone Marta 
Published: January 2025

Abstract

OBJECTIVE
To compare the pharmacokinetics of cannabidiol (CBD) and cannabidiolic acid (CBDA) in horses and to evaluate the safety of their chronic administration.

METHODS
CBD- and CBDA-rich oil (1 mg/kg) were administered orally twice daily to 7 adult horses over 6 weeks in a randomized, crossover design with a 2-week washout period. A 12-hour pharmacokinetic analysis was conducted on day 1 of each 6-week trial, followed by the measurement of peak and trough concentrations at weeks 1, 2, 4, and 6. The cannabinoids safety was assessed via daily physical examination, periodic bloodwork, and liver biopsy at the beginning and end of the study.

RESULTS
12-hour pharmacokinetics revealed a higher maximum serum concentration (103 vs 12 ng/mL) and greater area under the curve (259 vs 62 ng·h/mL) for CBDA when compared to CBD. Cannabidiolic acid nadir and peak serum levels over time ranged from 46 to 122 ng/mL, which was higher than CBD (12 to 38 ng/mL). Complete blood count and serum chemistry revealed no clinically relevant changes with either CBD or CBDA. No significant abnormalities were detected on liver ultrasonographic and histopathologic evaluation on day 0 and after both phases of the study.

CONCLUSIONS
A dose of either 1 mg/kg of CBD or CBDA administered long term appears safe; however, CBDA serum concentrations suggest superior absorption/retention.

CLINICAL RELEVANCE
Chronic cannabinoid supplementation in horses is safe. Considering the higher absorption of CBDA, its use is recommended to evaluate the therapeutic efficacy of this common hemp derived cannabinoid.
Bronchial vessel density is correlated with airway smooth muscle cell proliferation in horses with mild and moderate asthma
Authors: Millares-Ramirez Esther M. , Dupuis-Dowd Florence , Mainguy-Seers Sophie , Lavoie Jean-Pierre 
Published: January 2025

Abstract

OBJECTIVE
In severe equine asthma, structural remodeling of the airways ultimately leads to bronchial wall thickening and airflow obstruction. Increased bronchial vascularization has been described in horses affected by the severe form of the disease, but whether it contributes to bronchial remodeling in milder forms of asthma remains to be determined. In a blinded, retrospective case-control study, we evaluated the presence of bronchial angiogenesis in horses with mild and moderate equine asthma (MEA) and its correlation to airway smooth muscle remodeling.

METHODS
Endobronchial biopsies from the Equine Respiratory Tissue Biobank collected between August 14, 2014, and May 31, 2019, from 9 horses with MEA and 7 healthy controls were studied. The vascular basement membrane was identified by immunohistochemistry, allowing the measurement of the number of bronchial vessels, vascular area, and mean vessel size by histomorphometry. The correlations between angiogenic parameters, airway smooth muscle (ASM) remodeling features, and airway neutrophilia were studied.

RESULTS
No differences between groups were observed for the angiogenic parameters evaluated. The number of vessels was correlated to ASM cell proliferation in MEA horses (Spearman r = 0.73) but not in controls. Airway neutrophilia correlated negatively with mean vessel size in horses with MEA (Pearson r = −0.83) but not in control horses.

CONCLUSIONS
Major changes in bronchial vascularization do not occur in central airways in MEA.

CLINICAL RELEVANCE
Contrary to previous findings in horses with severe equine asthma, angiogenesis is not a prominent feature of MEA, but it might be associated with ASM remodeling.
Seniors Who Can’t Google Are Extinct Anyway... O. Aging, Dementia and Caregiving in Art
Authors: Jedličková Alice 
Published: January 2025

Abstract
With the increasing life expectancy without a significant increase in health quality, the number of seniors in the population requiring special care due to incapacity following neurodegenerative diseases and the demands on home and institutional care for these persons are increasing as well. What was once an individual family concern has become a major societal challenge. The implications of this issue and the experience of families caring for a senior patient have recently been increasingly reflected in the arts. In this paper, the focus is primarily on recent works of fiction and film from the Czech context (Urban: Dr. Alz, Vlasáková: Těla, Slavík: Tancuj Matyldo); other culturally related works are referred to for comparison. In the enquiry, social contexts and subjects that the artworks represent are examined; we distinguish between those focused on the patient and those tracking the changes in the family, whether they remain in the private sphere or include aspects of institutional care, whether they use the perspective of the patient or the caregiver; and what effects these practices achieve, i.e., how they can contribute to awareness and reflection of the issue and its social processing.
Specialist German Coursebook for Policing
Authors: Romová Hana 
Published: January 2025

Abstract
This review informs about a new textbook for students of the German language with specialist orientation on policing „Němčina (nejen) pro policisty“ („German (not only) for Police Officers“). It comprises topics from different German-speaking countries based on legal studies. As it is intended not only for students of the Police Academy of the Czech Republic in Prague, it can be used by a wider public since it is divided into several parts, including the topics of Security, Law, Criminal Law, Management, and Public Administration, Universities, and Communication. Enclosed, there is a Czech-German Vocabulary as well as German-Czech Vocabulary and Czech-German phrases. A detailed and beneficial Grammar review giving an overview of the necessary grammar needed to acquire the language can be found at the very end. Not only this is a reason why the textbook can be recommended for all levels of language learners.
Scale of Resistance of Buildings to Mining Influences – Applicability Assesment Through a Case Study
Authors: NOWAK Katarzyna , STRZAŁKOWSKI Piotr , SZOJDA Leszek 
Published: January 2025

Abstract
This paper presents a case study of the impact of continuous deformations and rock mass tremors on a single-family building, typical of Upper Silesia. In the areas subjected to the influence of ground deformation, a point method for assessing the resistance of buildings to these influences has been developed by the Central Mining Institute. As part of this method, the geometric parameters, structure, materials and technical condition of the facility, as well as the ground on which the building is located, are taken into account. A case study considers a building being simultaneously subjected to continuous deformations and mining tremors. The object’s resistance is assessed according to the point method and its technical condition is assessed after revealing the influence of ground deformation. This is used to assess the validity of the point method for the building. On the basis of the analyses of the state of deformation and the impact of tremors, conclusions are drawn regarding the need to make changes to the scale used to assess the category of resistance of buildings to the effects of continuous deformation.
Dynamic Tests of Pony Truss Railway Bridge Under Normal Operation
Authors: PRADELOK Stefan , POPRAWA Grzegorz 
Published: January 2025

Abstract
The article describes the application of dynamic tests during normal operation in assessing the technical condition of the railway bridge on the Nysa Łużycka River. The investigated structure consists of six steel pony truss spans. Operational modal analysis was used to identify dynamic parameters. The results obtained were applied to verify the numerical model used in the assessment process of technical condition and in determining the current load capacity of the structure created in the 1950s. The experiment conducted allowed us to observe the dynamic response of the pony-truss bridges. The study demonstrated that dynamic tests during normal operation and the use of other available environmental excitations could complement other non-destructive diagnostic methods. This proves that we can obtain useful information about the dynamic properties of a structure without closing the traffic and without the application of the ordinary dynamic test load.
Semi-Analytical Integration of the Accelerogram and Equations of Motion of a System Subjected to a Paraseismic Shock
Authors: WALENTYŃSKI Ryszard 
Published: January 2025

Abstract
The task of analysing shocks in areas of paraseismic mining activities is one of the important engineering tasks. Acceleration measurements should be integrated to receive velocity and displacement functions. Sometimes, numerical algorithms produce wrong results. This paper proposes a semi-analytical approach to this problem. The algorithm has been implemented within the Mathematica system. Moreover, this method has been applied to integration of the equation of motion.
Localization of Brutalist Architecture in Post-War Turkey: Three Unique Examples from Istanbul
Authors: BALCI ÖZTÜRK Özlem , ŞENYURT Oya 
Published: January 2025

Abstract
Brutalism, a revision of Modernism, originated in England in the 1950s and spread rapidly globally. This intercontinental expansion has led to distinctive local diversity in different geographies, from Europe to the America. Concurrent with global examples, brutalist buildings began to appear in Turkey in the early 1960s. Notably, in Istanbul, Brutalism has managed to localize and create unique examples. This study investigates the transition of Brutalism between geographies and its localization in Turkish Architecture. This study analyzes brutalist and brutalist-influenced structures in Istanbul. According to the results of this analysis, the unique examples of Manifaturacılar Retail Center, Istanbul Reklam Building, and Istanbul Officers’ Club are examined based on Reyner Banham principles to shed light on this localization in architecture. This study aims to provide an intercontinental case study of the integration of the expansion of global currents with cultural diversity. In this context, this study examines how Brutalism has been localized in Turkey and aims to expose unique examples that have yet to appear in the relevant literature.
The Reuse of Ceramic Materials in Architectural Design – Case Studies
Authors: MAGOSZ Agata 
Published: January 2025

Abstract
The global construction industry, notorious for resource consumption and waste production, has found an interest in the circular economy and sustainable development practices. This paper examines the reusability of ceramic building materials within architectural designs, emphasizing the principles of the circular economy and the 3R concept with a special focus on reuse. By performing a comparative analysis of 26 buildings the research explores the strategies for reusing ceramic materials. It categorizes reuse into two approaches: re-creation and transformation, while also considering the prevention of materials from becoming waste. The analysis scrutinizes the origin and function of materials, their placement in new designs, and the reasons behind their reuse. The study delineates recurring design patterns of using reclaimed building materials. It also categorizes three main approaches to incorporating reused elements into new structures.
The Factor Determining Effective Modelling of the Urban Spatial Transformation Process Based on Temporary Use
Authors: SZATON-ORLIŃSKA Karolina , OPANIA Szymon 
Published: January 2025

Abstract
The research involves analysing strategic models of urban spatial transformation processes in cities using temporary use as a significantly supportive tool or as the core of the transformations. The scope of the research includes identifying effective transformation models through the verification of cases based on established criteria and conducting detailed studies of selected cases to highlight the process elements, analyse their relationships, and assess the role of temporary use. The research method relies on critically comparing and analysing chosen cases. As a result, we have identified fundamental criteria that indicate the application of temporary use as part of a broader transformation process, along with supplementary indicators and characteristics that impact the effectiveness of the conducted transformations. These indicators can help model transformation processes based on temporary use. The research holds particular significance in utilizing temporary use within a broader, integrated urban transformation process that goes beyond a one-time intervention.
Effect of Silt and Clay Fraction Content on Frost Heave of Fine-Grained Soils
Authors: WITEK-ZIELONKA Kinga , PARYLAK Krzysztof , KILIAN Wojciech , ZIELONKA Łukasz 
Published: January 2025

Abstract
Frost heave in soils is a significant problem of geotechnical engineering. Despite the introduction of numerous simplified frost susceptibility criteria, there is still no clear relationship between the particle size distribution and their frost heaving susceptibility. Therefore, an experimental attempt was made to link the graining features of the four soils with the mechanisms of the formation of frost heave. The main aim of the study is to determine the influence of the content of silt and clay fractions on the height of the frost heave. The tested soils were characterized by a varied content of the silt fraction, which, together with smaller ones, amounted to 30%, 40%, 50% and 70%, and a variable content of the clay fraction amounting to 0%, 0%, 21% and 5% in individual soils, respectively. For the purposes of the experiment, a test stand was constructed that allows for testing 6 identical samples at a time. The tests were carried out in an open-system test, i.e. with the possibility of water flowing into the freezing zone. The total freezing process was carried out at -10°C and lasted 160 hours. On the basis of the obtained results of the increase in the height of the samples, it was shown that the silt with the highest total content of silt and clay fractions of 70% shows the highest frost heave and the smallest increase in the height of the samples in the freezing process is shown by sandy silt with the lowest sum of both these fractions. On the basis of the analysis of the results of the tested soils, it was found that the height of the frost heave was influenced by the presence of the clay fraction, but in connection with the presence of the silt fraction. In the frost heave soils, the content of the silt fraction influences the amount of the frost heave to the extent of more than two times smaller than the content of the clay fraction.
Optimization of the suspension procedure by Box-Behnken design for the determination of manganese, iron, and zinc in zeolite clinoptilolite with the TXRF system and insight into its antioxidant properties
Authors: Jablan Jasna , Štefan Maja Bival , Paler Dario , Kamenski Emma 
Published: January 2025

Abstract
Zeolites are a large family of minerals and the most studied is the naturally occurring clinoptilolite. They possess anti-inflammatory, antioxidant, and detoxifying properties which makes them valuable for medicinal use. Element analysis of zeolite’s composition is necessary for its precise chemical characterization, and within this work development of a suspension method for the determination of manga nese, iron, and zinc by total reflection X-ray fluorescence spec-trometry (TXRF) was presented. The Box-Behnken design based on the response surface methodology was applied to determine the optimal sample preparation conditions. The significant variables such as sample amount, volume deposition, and dispersant were selected as critical variables. Based on the results obtained, sample suspensions were prepared by weighing 10 mg of the sample and adding 1 mL of 5 % Triton X-100 with 10 mL Ga as internal standard and deposition volume was set at 10 mL. The results obtained with TXRF were comparable with those obtained with the FAAS method, indicating that this technique can be used instead of the conventional methods. Using the best analytical conditions, the limits of detection for trace elements were in the range of 0.2–0.6 mg kg–1. Trueness and precision of the results, evaluated by CRM sample analysis, were in most cases acceptable with recoveries values in the range of 104.9–111.4 % and relative standard deviations of 2–10 % (. = 6). Zeolites showed no ability to quench free radicals nor the ability to influence dietary antioxidants.
The Systemic Aspect of the Governance of Public Institutes: The Case of Slovenia
Authors: Kozjek Tatjana , Pečarič Mirko 
Published: January 2025

Abstract
The governance of any organisation comprises a system of rules, practises, and procedures that guide and control the organisation. The case study examines the processes, procedures, activities, and problems of decision-making at the level of Slovenian ministries in terms of compliance with strategic documents, action plans, programmes, and other ministerial documents. The research focussed on the administrative/implementation level, where planning, control, impact assessment and timely reaction to deviations are of particular importance. The aim was to analyse the coordination between ministries, departments and public institutions. The results show that there is no system and that the documents on which the institutions work are inadequate.