bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica
Fresen (Francoaceae)
Authors: Sinkam Gozo Danielle , Tonbou Calixte , Momeni Jean 
Published: April 2023

Abstract
Phytochemical screening of the three extracts (acetone, ethanol and methanol) from Bersama abyssinica
leaves revealed the presence of triterpenes, phenolic compounds and coumarins. The evaluation of the total phenolic content was achieved using the method of Folin–Ciocalteu allowed us to say that the acetone extract has the highest content of 41.73 mg EAG/g EX. Fractionation of this extract led to the isolation of two triterpenoids, namely ursolic acid (compound BE1) and its glucoside (compound BE2). Evaluation of antibacterial activity was carried out on three bacterial strains: Escherichia coli, Staphylococcus aureus and Clostridium perfringens using the method of diffusion in a solid medium. Results indicated that the three strains were sensitive to all extracts. Three strains were sensitive to the BE1 and two strains (E. coli and S. aureus) to the BE2. These results may justify the traditional use of parts of B. abyssinica
in the treatment of some intestinal diseases.
Velocity-Based Method in Free-Weight and Machine-Based Training Modalities: The Degree of Freedom Matters
Authors: Hernández-Belmonte Alejandro , Buendía-Romero Ángel , Pallares Jesús G. , Martínez-Cava Alejandro 
Published: April 2023

Abstract
Hernández-Belmonte, A, Buendía-Romero, Á, Pallares, JG, and Martínez-Cava, A. Velocity-based method in free-weight and machine-based training modalities: the degree of freedom matters. J Strength Cond Res 37(9): e500–e509, 2023—This study aimed to analyze and compare the load-velocity relationships of free-weight and machine-based modalities of 4 resistance exercises. Moreover, we examined the influence of the subject's strength level on these load-velocity relationships. Fifty men completed a loading test in the free-weight and machine-based modalities of the bench press, full squat, shoulder press, and prone bench pull exercises. General and individual relationships between relative intensity (%1RM) and velocity variables were studied through the coefficient of determination (R
2) and standard error of the estimate (SEE). Moreover, the velocity attained to each %1RM was compared between both modalities. Subjects were divided into stronger and weaker to study whether the subject's strength level influences the mean test (mean propulsive velocity [MPVTest]) and 1RM (MPV1RM) velocities. For both modalities, very close relationships (R
2 ≥ 0.95) and reduced estimation errors were found when velocity was analyzed as a dependent (SEE ≤ 0.086 m·s−1) and independent (SEE ≤ 5.7% 1RM) variable concerning the %1RM. Fits were found to be higher (R
2 ≥ 0.995) for individual load-velocity relationships. Concerning the between-modality comparison, the velocity attained at each intensity (from 30 to 100% 1RM) was significantly faster for the free-weight variant. Finally, nonsignificant differences were found when comparing MPVTest (differences ≤ 0.02 m·s−1) and MPV1RM (differences ≤ 0.01 m·s−1) between stronger and weaker subjects. These findings prove the accuracy and stability of the velocity-based method in the free-weight and machine-based variants but highlight the need to use the load-velocity relationship (preferably the individual one) specific to each training modality.
Analysis of Competition Performance Leading to Success at the International Powerlifting Federation World Championships Between 2013 and 2019
Authors: van den Hoek Daniel , Garrett Joel , Travis S. Kyle , Oxnard Kate , Howells Robert , Owen Patrick , Latella Christopher 
Published: April 2023

Abstract
van den Hoek, D, Garrett, J, Travis, SK, Oxnard, K, Howells, R, Owen, P, and Latella, C. Analysis of competition performance leading to success at the International Powerlifting Federation World Championships between 2013 and 2019. J Strength Cond Res 37(10): e555–e562, 2023—Despite being a global sport, there is a paucity of research investigating competition-related factors contributing to World Championship powerlifting success. Therefore, the aim of this study was to determine competition strategies that underpin gold medalists' (GMs) and silver or bronze medalists' (SBMs) performances. Data collected from open-age International Powerlifting Federation (IPF) World Championship events 2013–2019 were analyzed (1,312 competitors [males n = 734, females n = 578]). Attempt weight and success for the squat (SQ), bench press (BP), and deadlift (DL); ‘total’ competition scores; category (age, weight class, and sex); and placing were categorized into 3 groups: GMs, SBMs, and nonwinners (fourth place or lower). One-way analysis of variances determined between group differences. Odds ratios (ORs) for the likelihood of winning and placing (i.e., GMs or SBMs) were also calculated. The odds of winning a competition were increased 5.9 times for men and by 1.5 times for women, when successfully completing 8 or 9 of 9 lift attempts. These findings provide comprehensive insight into intracompetition-related factors that contribute to World Championship powerlifting success to directly inform coach and athlete strategies. This information may also hold relevance for competitive state or national competitions and extend to other similarly structured strength-based sports.
Estilo de aprendizagem e percepção do ambiente educacional de universitários da área biológica e da saúde
Authors: Cruz Paloma Soares Novello , Rocha Sheyla Ribeiro , Casalecchi Gabriel Avila , Germano Carla Maria Ramos 
Published: April 2023

INTRODUÇÃO: A abordagem ao aprendizado pode ser influenciada por fatores individuais e ambientais. O aprendizado profundo requer utilização de mecanismos cognitivos complexos e o envolvimento do estudante. OBJETIVO: Investigar a abordagem ao aprendizado de estudantes de graduação de cursos da área biológica e da saúde que utilizam metodologias tradicionais de ensino e sua percepção do ambiente educacional ao final da graduação. MÉTODO: Estudo transversal com estudantes de cursos da área biológica e da saúde de uma universidade pública. Dados coletados por meio de três questionários: sociodemográfico, o Questionário Revisado do Processo de Estudo (R-SPQ-2F) e Dundee Ready Education Environment Measure (DREEM). Para comparação de médias utilizou-se os testes t de Student ou Mann-Whitney. As correlações foram calculadas pelo Coeficiente de Spearman. A regressão linear múltipla foi utilizada para verificar a influência das variáveis na abordagem ao aprendizado. Análises estatísticas realizadas no programa SPSS (versão 26) e nível de significância de 5%. Para análises, estudantes divididos em dois grupos (cursos básicos e aplicados), considerando envolvimento em cuidados a saúde. RESULTADO: Os estudantes de ambos os grupos demonstraram utilizar mais a abordagem profunda do que a superficial (cursos básicos: 29,78 versus 22,00; aplicados: 30,16 versus 20,25), sem diferença significativa entre eles (p > 0,05). Para cursos básicos, estar empregado exerceu efeito negativo sobre a aprendizagem profunda, enquanto, para cursos aplicados, realizar iniciação científica aumentou o uso dessa abordagem. A percepção geral do ambiente educacional foi considerada “mais positiva do que negativa” (cursos básicos: 104,28 e cursos aplicados 120,47), sendo que alunos de cursos aplicados tiveram percepção mais positiva do ambiente e aqueles com emprego fixo uma percepção mais negativa. CONCLUSÃO: O uso de abordagem profunda foi superior à da superficial para todos os cursos e houve associação positiva entre o uso de abordagens profundas e melhor percepção do ambiente educacional. Fatores sociodemográficos, como a necessidade de ter um emprego durante a graduação, podem influenciar a abordagem ao aprendizado, bem como a percepção do ambiente educacional.
A comprehensive review on the molecular basis and therapeutic targets in prostate cancer
Authors: Militaru Florentina Claudia , Militaru Valentin , Crisan Nicolae , Bocsan Ioana Corina , Udrea Anghel Adrian , Catana Andreea , Kutasi Eniko , Militaru Mariela Sanda 
Published: April 2023

Prostate cancer is one of the most significant causes of morbidity and mortality in male patients. The incidence increases with age, and it is higher among African Americans. The occurrence of prostate cancer is associated with many risk factors, including genetic and hereditary predisposition. The most common genetic syndromes associated with prostate cancer risk are BRCA-associated hereditary breast and ovarian cancer (HBOC) and Lynch syndrome. Local-regional therapy, i.e., surgery is beneficial in early-stage prostate cancer management. Advanced and metastatic prostate cancers require systemic therapies, including hormonal inhibition, chemotherapy, and targeted agents. Most prostate cancers can be treated by targeting the androgen-receptor pathway and decreasing androgen production or binding to androgen receptors (AR). Castration-resistant prostate cancer (CRPC) usually involves the PI3K/AKT/mTOR pathway and requires targeted therapy. Specific molecular therapy can target mutated cell lines in which DNA defect repair is altered, caused by mutations of BRCA2, partner and localizer of BRCA2 (PALB2), and phosphatase and tensin homolog (PTEN) or the transmembrane protease serine 2-ERG (TMPRSS2-ERG) fusion. Most benefits were demonstrated in cyclin dependent-kinase 12 (CDK12) mutated cell lines when treated with anti-programmed cell death protein 1 (PD1) therapy. Therapies targeting p53 and AKT are the subject of ongoing clinical trials. Many genetic defects are listed as diagnostic, prognostic, and clinically actionable markers in prostate cancer. Androgen receptor splice variant 7 (AR-V7) is an important oncogenic driver and an early diagnostic and prognostic marker, as well as a therapeutic target in hormone-resistant CRPC. This review summarizes the pathophysiological mechanisms and available targeted therapies for prostate cancer.
Informe anual sobre la situación jurídico-pública de la Comunidad Autónoma de Extremadura en 2022
Authors: Álvarez García Vicente , Arias Aparicio Flor , Hernández Díez Enrique , Orgaz Valle Ángel , Tahirí Moreno Jesús Alí 
Published: April 2023

El Informe de la Comunidad Autónoma de Extremadura constituye una crónica de la situación jurídica y político-institucional de la región en el año 2022.
Las cuestiones principales que se analizan en este Informe son: en primer lugar, las principales circunstancias que rodean la actividad político-institucional de la región; en segundo lugar, las líneas centrales de su actividad normativa –legislativa y reglamentaria–; y, en tercer lugar, sus relaciones interadministrativas y conflictuales –esencialmente con la Administración General del Estado–. Se cierra el Informe con el examen de alguna cuestión de relevancia socio-económica para la región. En este año, nuevamente, hemos analizado el papel de Extremadura como territorio estratégico para la transición ecológica, puesto que a lo largo del mismo se han producido acontecimientos significativos en este ámbito.
High-dose stereotactic radiosurgery for large brainstem metastasis and its recurrence treatment
Authors: Romanova N. I. , Zubatkina I.  S. , Ivanov P. I. 
Published: April 2023

Background. Breast cancer contributed to 11.8 % of all the oncological diseases detected in Russia in 2020 and to 21.7 % of tumors detected among women. The frequency of brain metastases is estimated at 13–32 %. It is known that HER2 positive and triple negative breast cancers metastasize to the brain more frequently.Aim. To present the case of stereotactic high‑dose irradiation for a large brainstem metastasis from HER2 positive breast cancer and re‑irradiation of the recurrence.Materials and methods. Analysis of the results of stereotactic irradiation for a large brainstem metastasis from HER2 positive breast cancer and re‑irradiation of the recurrence with a local control over five years was performed.Results. The local control after five years did not show any signs of tumor progression or post‑radiation necrosis. The patient’s Karnofsky Performance Status was estimated at 100 points.Conclusions. The case shows the necessity of highly conformal stereotactic dose delivery to the tumor, precise determination of tumor boundaries on high resolution thin slice magnetic resonance imaging, verification of recurrence using metabolic studies and hypofractionated dose delivery. It remains open whether and to what extent target therapy may contribute to local control.
Impact of Site-Response Characterization on Probabilistic Seismic Hazard in the Po Plain (Italy)
Authors: Mascandola Claudia , Barani Simone , Albarello Dario 
Published: April 2023

ABSTRACT
We present a probabilistic seismic hazard analysis (PSHA) for the entire Po Plain sedimentary basin (Italy)—one of the widest Quaternary alluvial basins of Europe, to evaluate the impact of site-response characterization on hazard estimates. A large-scale application of approach 3 of the U.S. Nuclear Regulatory Commission (NRC) to include seismic amplification in the hazard is presented. Both 1D amplification related to stratigraphic conditions and 3D amplification due to basin effects are considered with the associated uncertainties, and their impact on the hazard is analyzed through a sensitivity analysis. Whereas 3D basin effects are considered through the application of an empirical, spatial invariant correction term, 1D amplification was estimated throughout the study area by means of dynamic (equivalent linear) ground-response analysis. To separate aleatory variabilities and epistemic uncertainties related to site response, a partially nonergodic approach is used. The results provide a finer picture of the actual seismic hazard, highlighting those areas where the ground motion is affected by amplification effects due to local or regional geological features. We found that, for a return period of 475 yr, neglecting basin effects produces a 30% underestimation of the seismic hazard in the long-period (&gt;1 s) range. Moreover, with reference to the hazard model adopted, such effects are responsible for most of the epistemic uncertainty (up to 80%) in the results. Therefore, such effects deserve special attention in future research related to PSHA in the Po Plain sedimentary basin.
Temporal Characteristics of ‘Bribery’ and ‘Unemployment’ as Russian Culture Representatives Antivalues
Authors: Ильина В.А. , Вашунина И.В. 
Published: April 2023

Анализируется современное представление носителей русской культуры об антиценностях «взяточничество» и «безработица» при помощи времени, а точнее, темпоральных шкал, используемых в качестве инструмента анализа содержания ценностей в языковом сознании. На основе полученных экспериментальных данных выявлено, что «взяточничество» и «безработица» в сознании носителей русской культуры обладают темпоральной характеристикой.
The article analyzes the Russian culture representatives’ modern perception of bribery and unemployment as antivalues with the help of temporal scales used as a tool for studying the content of antivalues in the linguistic consciousness. Relying on the experimental data obtained, it was revealed that bribery and unemployment have a temporal characteristic in the linguistic consciousness of Russian culture representatives.
Evaluative Interpretation of Events by Actional Verbs with the Meaning of Destruction of an Object
Authors: Логина Т.В. , Селезнева И.Л. , Орешина Е.Е. 
Published: April 2023

Любое событие окружающей действительности находит свое отражение в человеческой речи. Выбор лексико-семантических средств помогает выразить отношение говорящего к событию. Благодаря уникальным семантическим свойствам глагол раскрывает разнообразные аспекты действия: его тип, способ, инструмент, объект. Анализируются способы оценочной интерпретации события акциональными глаголами со значением уничтожения и разрушения одушевленного объекта. Среди основных компонентов оценочной интерпретации события уничтожения рассматриваются объект уничтожения и его количественные характеристики, способ, интенсивность действия, цель, инструмент уничтожения. Представлены примеры употребления акциональных глаголов со значением уничтожения и разрушения одушевленного объекта в современном английском языке.
All events of the world around us are reflected in human speech. The choice of lexical and semantic means helps the speaker to express his attitude to the event. Due to unique semantic properties, a verb reveals various aspects of the action – its type, method, instrument (tool), object. The article analyzes the ways of evaluative interpretation of the event by actional verbs with the meaning of destruction of an animate object. The main components of the evaluation interpretation of the destruction event are the object of destruction and its quantitative characteristics, method, intensity of the action, purpose, and instrument (tool) of destruction. The article presents examples of the use of actional verbs with the meaning of destruction of an animate object in the modern English language.
Lexical Means of Creating an Enemy Image in Modern Media
Authors: Веретенников А.С. 
Published: April 2023

Рассматриваются лексические средства, реконструирующие образ врага в современных средствах массовой информации. Выявлены ключевые оценочные характеристики образа врага и способов их вербальной объективации. Анализ материалов осуществляется в русле когнитивно-дискурсивного подхода с опорой на положения классической семантики. Образ врага трактуется в работе как оценочный конструкт преимущественно отрицательной маркированности. Вербализаторами оценки выступают идеологемы с негативной коннотацией и сопряженные с ними концепты, оценочная лексика, метафоры.
The article is devoted to the study and analysis of lexical means that reconstruct the image of the enemy in modern media. The purpose of the article is to identify the key evaluative characteristics of the enemy image and ways of their verbal objectification. The analysis is carried out in a tideway of the cognitive-discursive approach based on the provisions of classical semantics. The image of the enemy is interpreted as an evaluative construct, mostly negatively labeled. Verbalizers of evaluation are negatively marked ideologemes and related concepts, evaluative vocabulary, metaphors.
Lingvoecology and Modern Language Policy (On the Material of German and Russian)
Authors: Колесник Т.И. 
Published: April 2023

Рассматривается проблема сохранения чистоты языка в мультикультурном обществе. На примере Германии и России исследуются направления языковой политики стран, определяется правовой статус немецкого и русского языков, разграничиваются понятия «государственный язык», «официальный язык», «национальный язык». Проблема сохранения и развития государственного языка как основного средства общения особенно актуальна в многонациональном обществе. Приведено сравнительное описание статуса официальных языков и основных направлений языковой политики Германии и России как мультикультурных стран.
The article deals with the problem of maintaining the purity of language in a multicultural society. Using the examples of Germany and Russia, the directions of the countries’ language policy are examined, the legal status of the German and Russian languages is defined, and the concepts of “state language”, “official language” and “national language” are distinguished. The problem of protection and development of the state language as the main means of communication is of particular relevance in a multinational society. The article focuses on the comparative description of the status of official languages and the main directions of the language policy of Germany and Russia as multicultural countries.
Th e Role of Idioms in the Formation of Socio-Cultural Competence of Youth Students and Readiness for Interpersonal Interaction in Conditions of...
Authors: Ма Ц. 
Published: April 2023

Исследуется роль фразеологизмов и идиом в формировании готовности китайских студентов вступать в межличностное взаимодействие с носителями русского языка на этапе обучения. Выявляется образовательный потенциал идиом разных групп и категорий в изучении китайскими студентами русского языка как иностранного. Приведены примеры комплексных заданий, предполагающих освоение идиом и фразеологизмов, направленных на формирование коммуникативной компетенции и готовности вступать в диалог, которые могут быть использованы при преподавании русского языка.
The article is devoted to the study of the role of phraseological units and idioms in shaping the readiness of Chinese students to engage in interpersonal interaction with native speakers of the Russian language at the stage of learning. The educational potential of idioms of different groups and categories in the study of Russian as a foreign language by Chinese students is revealed. Examples of complex tasks are given, involving the development of idioms and phraseological units aimed at the formation of communicative competence and readiness to enter a dialogue, which can be used in teaching the Russian language.
Linguistic Localization as an Object of Research in Contemporary Translation Studies
Authors: Владимов Е.Н. 
Published: April 2023

Представлен сравнительный анализ существующих подходов к толкованию понятия «локализация», на основании которого выделены сущностные характеристики объекта исследования и предложено его уточненное определение.
The paper undertakes a comparative review of existing interpretations of the term ‘localization,’ revealing the essential characteristics of the research object, and suggesting its refined definition as a result.
Mantık - Matematik İlişkisi Bağlamında Geçerli Kıyas Kalıplarının Venn Şeması ile Gösterimi ve Yorumlanması
Authors: Kömürcü Kamil , KIRAS Halit 
Published: April 2023

“Mantık - Matematik ilişkisi bağlamında geçerli kıyas kalıplarının Venn şeması ile gösterimi ve yorumlanması” adını taşıyan bu çalışmada kıyas kalıplarını matematiksel bir gösterim şekli ile daha sembolik hale getirmeye ve farklı bir bakış açısı sunmaya çalıştık. İlk olarak kısaca mantık matematik ilişkisini ele aldık. Ardından özetle kıyas üzerinde durduk. Daha sonra gösterim şeklinin sembolik olması sebebiyle ana hatlarıyla sembolik mantığın tarihçesi, yapısı, gelişimi ve Venn şemaları hakkında bilgi verdik. Son olarak önceki bölümde verilen örnekleri Venn şeması yöntemi ile göstermeye çalıştık. Sonuçta ise ulaşılan kanaatlere yer verdik.
13. Tefsir Akademisyenleri Koordinasyon Toplantısı ve Akademik Tefsir Çalışmaları Sempozyumu (27-28 Mayıs 2016 Ankara)
Authors: Çalışkan İsmail 
Published: April 2023

27-28 Mayıs 2016 tarihinde Ankara Üniversitesi İlahiyat Fakültesi Tefsir Anabilim Dalı'nın organizasyonu ile yapılan XIII. Tefsir Akademisyenleri Koordinasyon Toplantısı ve Akademik Tefsir Çalışmaları Sempozyumu toplantısının tanıtım yazısı.
Wzornictwo przemysłowe zakładów odlewniczych z terenu powiatu koneckiego od lat 70. XIX wieku do 1939 roku
Authors: Rutkowska-Siuda Daria 
Published: April 2023

Żeliwo w połowie XIX w. zyskiwało coraz większą popularność zarówno w budownictwie jak i wzornictwie przesyłowym. Bogate tradycje odlewnicze powiatu koneckiego należącego do Staropolskiego Okręgu Przemysłowego w większości budują zakłady rozwijające się na przełomie XIX i XX w. Należy zwrócić szczególną uwagę na Odlewnię w Stąporkowie oraz zakłady Piotr Ławacz, Szai Kronenbluma i Józef Mintz w Końskich. Niniejszy artykuł skupia się na analizie jedynie fragment asortymentu odznaczającego się ciekawymi formami. Drzwiczki piecowe można podzielić na trzy kategorie wzorów opartych na: ornamencie historyzującym, motywach secesyjnych, formach geometrycznych. Prezentowane w artykule modele powielały się w asortymencie wszystkich zakładów. Ich popularność na ówczesnym rynku była ogromna, na co wskazują liczne zachowane przykłady.