bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fe/Ni redox synergistic sodium persulfate photocatalytic depolymerization of the sinocalamus oldhami alkali lignin for the directional synthesis of aromatic aldehydes
Authors: Xu Zhuangqin , Liu Minghua , Lin Jiantao , Ye Xiaoxia 
Published: February 2023

Abstract
Background
Recently, it was full of challenges to realize the mild and directional oxidative depolymerization of lignin at room temperature and pressure. The sinocalamus oldhami alkali lignin (SOAL) was depolymerized into aromatic aldehydes by cooperating LaFe0.9Ni0.1O3 (LFNO-0.1) with sodium persulfate (PDS) under visible light irradiation.
Result
Under the best conditions of reaction time of 105 min, catalyst dosage of 0.25 g, sodium persulfate of 0.15 g, 80% of lignin was converted and the yield of monomer compounds was up to 2.97 mg/g. In addition, the yield of p-hydroxybenzaldehyde was 1.86 mg/g respectively. And, the selectivity of p-hydroxybenzaldehyde reached about 63% in the monomer product. The effect sequence of factors in the system were as follows: holes > 1O2 > SO4−· > O2−· > ·OH, which could lead to the cleavage of the benzene ring, C-C, C–O, C-H bonds in the internal structure of lignin.
Conclusion
The study found that LFNO-0.1/PDS played a synergistic role in the SOAL depolymerization. The study was beneficial for mild depolymerization of lignin and conform carbon peaking and carbon neutrality goals.
Peripheral Blood Cell Profile and Monocyte HDL Ratio in Alzheimer’s Disease: A Hospital-Based Case-Control Study
Authors: Dikbas Husniye Aylin , Seker Demet , Dikbas Oguz 
Published: February 2023

Abstract
Background: The monocyte/HDL-C ratio (MHR) has emerged as a new marker of inflammation in recent years. The purpose of this research was to examine the distinction of MHR between individuals with Alzheimer's disease (AD) and healthy individuals, and to assess its feasibility as a straightforward and easily computable biomarker for evaluating the severity of the disease.
Methods: A retrospective study was conducted with 184 subjects admitted for various reasons at the Neurology Outpatient Department of Giresun University Faculty of Medicine. The hospital’s electronic patient record data between September 2021 and April 2022 were screened.
Results: Individuals diagnosed with AD were classified into three subgroups based on the progression of the disease: mild, moderate, and severe. MHR was higher in the moderate and severe dementia subgroups compared with the controls according to subgroup analysis (P=0.013). An increase in MHR was found in patients with AD. The multivariate logistic regression analysis model revealed that a one-unit increase in MHR resulted in 1.081 times increase in the risk of AD (OR: 1.081 (CI: 1.005-1.162; P= 0.035).
Conclusion: This is the first study in the literature exhibiting an increased MHR value in AD. High MHR values in the late stages of the disease demonstrate a potential for MHR to predict the prognosis. It might be a marker reflecting increased cardiovascular risk and an unfavorable prognosis in patients with AD.
C-reactive protein mediates the association between fruit and vegetable intake, and mortality among US adults
Authors: Laouali Nasser , Chen Chen , Shah Sanam , Oulhote Youssef , Benmarhnia Tarik 
Published: February 2023

Abstract
Background
Fruit and vegetable (FV) are part of a healthy diet as their consumption has been consistently associated with a reduction in the risk of premature mortality and various biomarkers of inflammation have been hypothesized to partially explain such relationships. However, empirical evidence quantifying the mediating role of such biomarkers in the relationship between FV intake and mortality is not available at the population level. The present study examines the association between FV daily servings or objectively measured biomarkers of FV intake and mortality and the extent to which a biomarker of inflammation mediates these associations.
Methods
We used data on 13,892 adults aged ≥ 20 years enrolled in the NHANES-III between 1988 and 1994 and followed up through Dec 31, 2015. Daily serving of FV was assessed using 24-hour dietary recall and mortality was determined from the National Death Index records. Serum concentrations of 6 biomarkers of FV intake and C-reactive protein (CRP) were measured in blood samples. We used a causal mediation analysis with Aalen additive hazards models to decompose the total effect of FV intake on mortality into natural direct and indirect (through CRP level) effects while controlling for a priori-defined confounders. We also calculated the proportion mediated.
Results
Over the follow-up period, 5023 participants died (1503 from cardiovascular diseases, and 1110 from cancer). High daily FV serving (at least 5 servings) and high level of FV biomarker (> median) were associated with a lower risk of death compared to low daily servings and low level of FV intake biomarker, respectively. Comparing participants with high scores to low scores of the FV intake biomarker, we observed reduced hazard rate difference for all-cause (-0.54 per 10000 person-year [95% CI -0.72 to -0.33]), cardiovascular disease (-0.19 per 10000 person-year [95% CI -0.26 to -0.12]), and cancer (-0.10 per 10000 person-year [95% CI -0.14 to -0.06]) mortality that can be attributed to subsequent decreases in CRP. The corresponding proportions mediated were 16%, 17%, and 10% for all-cause, cardiovascular, and cancer mortality, respectively.
Conclusion
Our findings confirmed the beneficial effects of FV intake and that the effects were partly mediated by a reduction in circulating CRP.
The Effect of Statin Therapy on Serum Uric Acid Levels: A
Systematic Review and Meta-analysis
Authors: Akbari Abolfazl , Razmi Mahya , Rafiee Mahdi , Watts Gerald F. , Sahebkar Amirhossein 
Published: February 2023

Background:
Elevated concentrations of serum uric acid (SUA) are associated
with several conditions, including cardiovascular disease. The present study aimed to estimate
the impact of statin therapy on SUA levels through a systematic review and meta-analysis of
clinical trials.

Methods:
PubMed, Embase, Web of Science, and Scopus were searched on January 14, 2022,
to identify eligible clinical trials. The intervention group received statins as monotherapy or in
combination with other drugs, and the control group received non-statins or placebo. Studies
reporting SUA levels before and after treatment were selected for further analysis. Finally, the
data were pooled, and the mean changes in SUA, total cholesterol, high-density lipoprotein
(HDL), low-density lipoprotein (LDL), and triglycerides were reported.

Results:
Out of 1269 identified studies, 23 were included in the review. A total of 3928 participants
received statin therapy, and 1294 were included in control groups. We found a significant
reduction in SUA levels following statin therapy (mean difference (MD) = -26.67
μmol/L with 95% confidence interval (CI) [-44.75, -8.60] (P =0.004)). Atorvastatin (MD =
-37.93 μmol/L [-67.71, -8.15]; P < 0.0001), pravastatin (MD = -12.64 μmol/L [-18.64, -6.65];
P < 0.0001), and simvastatin (MD = -5.95 μmol/L [-6.14, -5.80]; P < 0.0001), but not rosuvastatin,
were significantly associated with a reduction in SUA levels. An analysis comparing different
types of statins showed that pravastatin 20-40 mg/day could significantly reduce SUA
when compared to simvastatin 10-20 mg/day (-21.86 μmol/L [-36.33,-7.39]; P =0.003).

Conclusion:
Statins were significantly associated with a decrease in SUA levels, particularly
atorvastatin, which was found to be most effective in lowering SUA. Atorvastatin may be the
most appropriate cholesterol-lowering agent for patients with or at risk of hyperuricemia.
Analysis of the Curative Effect of Diffusion Tensor Imaging-Guided
Percutaneous Endoscopic Lumbar Discectomy
Authors: Zhang Hengwei , Lian Zheng , Gao Shanshan 
Published: February 2023

Background:
Diffusion tensor imaging (DTI), a novel method of describing nerve structure, is a special form of magnetic resonance imaging (MRI). This new imaging method can be used to
locate the diseased nerve roots in lumbar disc herniation.

Objective:
The objective of this study is to compare patient outcomes between single-level and doublesection percutaneous endoscopic lumbar discectomy (PELD) in the treatment of lumbar intervertebral
disc herniation with single nerve root compression, where single-sided PELD is guided by magnetic
resonance diffusion tensor imaging (DTI).

Methods:
The clinical data of patients with lumbar intervertebral disc herniation with double compression of single nerve root symptoms in the Affiliated Hospital of Weifang Medical University from
January 2019 to May 2021 were retrospectively summarized and divided into single-level percutaneous endoscopic discectomy (PELD) group after DTI localization and double-section PELD group. The
operation time, intraoperative bleeding, VAS score and JOA score of the two groups were compared,
as well as the preoperative and postoperative fractional anisotropy (FA) values in the DTI group.

Results:
The operation time and intraoperative bleeding volume of patients in the DTI group were
significantly lower than those in the double segment group, and there was no significant difference
between VAS scores and JOA scores in the two groups. After the operation, the nerve root FA value of
the responsible compression site of patients in the DTI group increased significantly, but it was still
lower than the healthy symmetrical part.

Conclusion:
The single-level PELD based on DTI has achieved a similar effect to that of the doublesegment PELD in 3 months after the operation, which can improve the FA value of the lesion nerve
root. Its bleeding amount is less, and the operation time is shorter, but the efficacy of this technology
still requires long-term follow-up of large samples.
Experiment with the X-band radar at the Nizhny Novgorod cable car: First Results
Authors: Ponur Kirill , Titchenko Yuriy , Karaev Vladimir , Meshkov Evgeniy , Panfilova Mariya , Krylov Andrey , Khakin E. 
Published: February 2023

The first results of data processing of the experiment on the Nizhny Novgorod cable car are presented. A pulsed X-band radar was installed on a technological trolley and performed measurements while moving in two modes that worked sequentially. In the radio altimeter mode, the reflected waveform was measured and the distance to the scattering surface was determined. In the Doppler mode, the Doppler spectrum of the reflected signal was measured, which contains information about the statistical
parameters of the surface. Data processing was carried out and the first results confirmed the assumption that the Doppler spectrum can be an effective tool for classifying the type of the underlying surface according to the "ice/water" criterion. Subsequent data processing will allow us to evaluate the accuracy of the developed algorithms.
Pengembangan Modul Pembelajaran Matematika Berbasis Etnomatematika (Tradisi Budaya Bugis)
Authors: Husnul Khatimah  , Sitti Mania  , Ahmad Farham Majid  , Nur Yuliany  
Published: February 2023

Tujuan penelitian ini untuk mengetahui proses pengembangan bahan ajar berbasis etnomatematika. Model penelitian yang digunakan adalah ADDIE yang terdiri dari beberapa fase yaitu Analysis (Analisis), Design (Desain), Development (Pengembangan), Implementation (Implementasi), dan Evaluation (Evaluasi). Produk yang dikembangkan berupa bahan ajar yaitu modul berbasis etnomatematika (tradisi budaya Bugis) pada materi bangun ruang sisi datar yang diujicobakan pada siswa kelas VIII MTs Negeri Pangkep sebanyak 17 orang. Instrumen yang digunakan dalam penelitian ini adalah lembar validasi ahli, lembar observasi aktivitas siswa, lembar observasi aktivitas guru dalam keterlaksanaan pembelajaran, angket respon siswa, angket respon guru, dan tes hasil belajar. Berdasarkan hasil penelitian uji coba terbatas yang dilaksanakan, modul berbasis etnomatematika (tradisi budaya Bugis) pada materi bangun ruang sisi datar di kelas VIII MTs Negeri Pangkep telah memenuhi kriteria kevalidan, kepraktisan dan keefektifan.
Hubungan antara Cara Belajar dan Kecemasan Matematika dengan Prestasi Belajar Peserta Didik Selama Pandemi Covid-19
Authors: Rahmayanti  , Kusumayanti Andi , Rahman Ulfiani 
Published: February 2023

Penelitian ini merupakan jenis penelitian korelasional yang bertujuan untuk mendeskripsikan hubungan antara cara belajar, kecemasan matematika dan prestasi belajar selama masa pandemi Covid-19. Pendekatan penelitian ini adalah kuantitatif dengan metode penelitian analisis desktiptif dan analisis inferensial. Teknik analisis data yang digunakan adalah pearson correlation dengan taraf signifikansi sebesar 5%. Instrumen yang digunakan dalam penelitian ini berupa instrumen berupa angket pernyataan peserta didik terkait cara belajar dan kecemasan matematika, sedangkan data prestasi belajar diperoleh dari nilai ujian sekolah matematika. Populasi dalam penelitian ini adalah seluruh peserta didik kelas XII SMA Negeri 9 Takalar tahun pelajaran 2021/2022 yang berjumlah 61 peserta didik. Hasil penelitian ini menunjukkan bahwa: (1) cara belajar peserta didik mayoritas pada interval sedang 60,00-67,00 sebanyak 21 peserta didik dengan frekuensi komulatif (34%), kecemasan matematika mayoritas peserta didik pada interval sedang 42,00-50,00 sebanyak 24 peserta didik dengan frekuensi komulatif (39%). (2) terdapat hubungan yang signifikan antara cara belajar dengan prestasi belajar peserta didik yang menunjukkan nilai koefisien korelasi sebesar 0,638 dan 𝑝 < 0,05. (3) terdapat hubungan yang signifikan antara kecemasan matematika dengan prestasi belajar yang menunjukkan nilai koefisien korelasi sebesar −0,314 dan 𝑝 < 0,05. (4) terdapat hubungan yang signifikan antara cara belajar dan kecemasan matematika dengan prestasi belajar peserta didik selama pandemi Covid-19 yang ditunjukkan dengan nilai koefisien korelasi sebesar 0,676 dan 𝑝 < 0,05 dengan arah korelasi positif. Dapat disimpulkan bahwa apabila semakin tinggi cara belajar dan semakin rendah kecemasan matematika maka akan menghasilkan prestasi belajar peserta didik akan tinggi, sebaliknya jika semakin rendah cara belajar dan semakin tinggi kecemasan matematika maka akan menghasilkan prestasi belajar yang kurang/rendah.
Pendekatan Pakematik untuk Meningkatkan Hasil Belajar IPA Terpadu pada Peserta Didik Kelas IX.5 SMPN 1 Tarowang
Authors: Suhardiman Suhardiman , Armita Cahyani  , Ummu Kalsum  , Roni Ririn  , Andi Firta Nurwafiq Azizah  , Belinda Dwi Utami  
Published: February 2023

Penelitian ini merupakan penelitian tindakan kelas yang bertujuan untuk mengetahui pelaksanaan Pembelajaran Aktif, Kreatif, Efektif, dan Menyenangkan Memanfaatkan Teknologi Informasi dan Komunikasi (PAKEMATIK) dan meningkatkan hasil belajar peserta didik kelas IX.5 mata pelajaran IPA Terpadu dengan materi kemagnetan di SMP Negeri 1 Tarowang Kab. Jeneponto dengan pendekatan PAKEMATIK. Subjek penelitian ini adalah peserta didik kelas IX.5 yang berjumlah 23 orang. Penelitian ini dilaksanakan dengan dua siklus dengan lima kali tatap muka setiap siklus. Adapun alur penelitian ini menggunakan model Kemmis dan Mc Taggart yang terdiri dari perencanaan, tindakan, observasi, dan refleksi.. Hasil penelitian ini menunjukkan bahwa terjadi peningkatan hasil belajar peserta didik dengan menggunakan pendekatan PAKEMATIK, dengan hasil pada setiap siklus yaitu dari 52% menjadi 86% pada siklus I dan siklus II. Implikasi penelitian ini adalah guru dapat mengimplementasikan pendekatan PAKEMATIK sebagai alternatif pembelajaran di kelas agar tidak monoton dan lebih bervariasi.
Decrease Levels of Mercury (Hg2+) using Vetiver Plants (Vetiveria zizanioides) in Mining Waste at Mandailing Natal Regency
Authors: Irfandi Rizal , Febriani Danur Riny 
Published: February 2023

Fitoremediasi merupakan salah satu metode penanganan lahan tercemar akibat pertambangan. Penelitian ini bertujuan untuk mengkaji pengaruh penanaman tanaman vetiver (Vetiveria zizanioides) terhadap fitoremediasi limbah pertambangan yang tercemar merkuri (Hg) di Kabupaten Mandailing Natal untuk mengurangi dampak pencemaran lingkungan akibat aktivitas pertambangan. Penelitian ini dilaksanakan selama tiga bulan di Rumah Kaca FMIPA Universitas Negeri Medan dan Laboratorium Balai Riset dan Standardisasi Kota Medan. Jenis penelitian ini adalah penelitian eksperimental dengan Rancangan Acak Lengkap. Jumlah kombinasi perlakuan terdiri atas 4 variasi paparan limbah dengan 2 kali pengulangan pengujian kandungan merkuri pada tanaman. Dari hasil penelitian diperoleh tanaman vetiver mampu menyerap logam merkuri pada media tanam yang dikontaminasi dengan limbah asli pertambangan paling tinggi sebesar 7,1045 mg/Kg dan sebesar 15,68 mg/Kg pada kontaminasi limbah sintetik selama 12 hari pemaparan. Dengan bertambahnya waktu fitoremediasi, tanaman akar wangi (Vetiveria zizanioides) mampu mengakumulasi lebih banyak logam berat merkuri (Hg) yang terdapat di dalam tanah.
The Effect of Extraction Time of Raja Nangka Banana Peel as Capping Agent on the Characteristic and Antibacterial Activity of ZnO Nanoparticles Against Staphylococcus epidermidis
Authors: Adinnia Apriandini  , Fajaroh Fauziatul , Aliyatulmuna Adilah , Ciptawati Endang 
Published: February 2023

A green chemistry-based ZnO nanoparticle synthesis method based on plant extracts has been developed. Raja nangka banana peel is one of them. The extraction time is one of the elements that influences the amounts of secondary metabolites. The longer the extraction time, the more secondary metabolites are obtained. If the optimal time is exceeded, the secondary metabolite compounds will decrease. The purpose of this research was to determine the optimal time to extract secondary metabolites from the raja nangka banana peel and to know the effect of extraction time on the characteristics of ZnO nanoparticles, which include morphology, size, and antibacterial activity against Staphylococcus epidermidis. The steps of this research: maceration, phytochemical tests and total levels tests, synthesis of ZnO nanoparticles, characterization, and antibacterial activity test against Staphylococcus epidermidis. Maceration for 24 hours is the best time for extracting secondary metabolites from raja nangka banana peels. The SEM test results show that the morphology of the three samples had agglomeration. The ZnO nanoparticles with 24-hour raja nangka banana peel extract had a smaller size of 295.2 nm and were spherical. Inhibition zone diameter from ZnO nanoparticles with 24-hour raja nangka banana peel extract has a larger area of 5.65 mm.
HUBUNGAN SANITASI FISIK RUMAH DENGAN KEJADIAN ISPA PADA BALITA DI TPA TAMANGAPPA ANTANG MAKASSAR TAHUN 2020
Authors: Lestari Andi suci indah 
Published: February 2023

ISPA atau Infeksi Saluran Pernapasan Akut adalah infeksi akut yang mengenai satu atau beberapa organ saluran pernapasan yang disebabkan oleh patogen-patogen seperti bakteri, virus, atau jamur.Prevalensi kejadian ISPA pada balita di Kota Makassar berdasarkan Profil Kesehatan Provinsi Sulawesi Selatan tahun 2017, jumlah kasus sebesar 147.848 orang. Penelitian ini bertujuan untuk mengetahui hubungan lingkungan fisik berupa ventilasi, kelembapan rumah, kepadatan hunian, pencahayaan rumah, paparan asap rokok, penggunaan obat nyamuk, letak dapur, jenis lantai, bahan atap rumah, sarana air bersih, sarana jamban, dan sarana tempat sampah dengan kejadian ISPA pada balita. Penelitian ini merupakan penelitian kuantitatif dengan desain cross sectional study yang dilakukan di TPA Tamangappa Antang Makassar dengan jumlah sampel 90 balita menggunakan teknik Non Random Sampling jenis Purposive Sampling. Pengumpulan data dari responden dilakukan menggunakan kuesioner dan lembar observasi. Analisis data menggunakan uji chi square p<0,05 dan uji phi 0,001 < φ < 1,00. Hasil penelitian menunjukkan ada hubungan dengan ventilasi (p=0,000, φ=0,433), ada hubungan dengan kelembapan (p=0,000, φ=0,456), ada hubungan dengan kepadatan hunian (p=0,036, φ=0,264), ada hubungan dengan pencahayaan rumah (p=0,002, φ=0,344), ada hubungan dengan paparan asap rokok (p=0,000, φ=0,531), ada hubungan dengan penggunaan obat nyamuk (p=0,001, φ=0,382), tidak ada hubungan dengan letak dapur (p=0,843, φ=0,045), tidak ada hubungan dengan jenis lantai (p=0,099, φ=0,196), ada hubungan dengan bahan atap rumah (p=0,007, φ=0,307), tidak ada hubungan dengan sarana air bersih (p=0,843, φ=0,045), tidak ada hubungan dengan sarana jamban (p=0,646 φ=0,072), ada hubungan dengan sarana tempat sampah (p=0,000, φ=0,422). Kata Kunci : ISPA, Balita, Sanitasi Fisik Rumah, Ventilasi, Kelembapan, Pencahayaan, Kepadatan Hunian
HUBUNGAN ANEMIA DENGAN KEJADIAN KETUBAN PECAH DINI DI RUMAH SAKIT UMUM DAERAH BATARA SIANG PANGKEP PERIODE JANUARI 2019 – JUNI 2021
Authors: Nur Fatimah Sry Mulya , Saharuddin  , Nadyah  
Published: February 2023

Ketuban Pecah Dini (KPD) adalah pecahnya selaput ketuban sebelum waktu persalinan dengan penyebab yang belum diketahui jelas, akan tetapi ada beberapa faktor yang berhubungan salah satunya adalah anemia dengan sebesar 8% dari seluruh kehamilan merupakan KPD dan faktor utama yang menyebabkan mortilitas dan morbiditas perinatal sehingga perlu intervensi lebih lanjut mengenai solusi untuk mengendalikan mortalitas dan morbiditas agar bisa mencapai target atau penurunan yang signifikan salah satunya dengan mengenali faktor risiko KPD. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara anemia dengan kejadian KPD di Rumah Sakit Umum Daerah Batara Siang Pangkep. Penelitian ini menggunakan rancangan penelitian observasional analitik dengan pendekatan Case control. Sampel dalam penelitian ini adalah ibu inpartu yang terdiagnosis Ketuban Pecah Dini (KPD) sebagai kasus dan yang tidak terdiagnosis KPD sebagai control. Data yang dikumpulkan dalam penelitian ini adalah menggunakan data sekunder dari rekam medis RSUD Batara Siang. Pengolahan dan analisa data dilakukan dengan teknik univariat dan bivariat dengan menggunakan Uji kai kuadrat. Sampel yang didapatkan dari penelitian ini sebanyak 68 sampel. Hasil penelitian ini didapatkan, hubungan signifikan antara hemoglobin dan hematokrit dengan kejadian KPD. Dari penelitian ini disimpulkan terdapat hubungan antara anemia dengan kejadian KPD.
Hubungan Pemberian Air Susu Ibu (Asi) Eksklusif Dan Paparan Asap Rokok Terhadap Kejadian Pneumonia Pada Balita Di RSUD Labuang Baji Makassar Periode Juli 2018 – Juli 2019
Authors: Pramei Andi Rara , Andi Tihardimanto  , Syatirah Jalaluddin  
Published: February 2023

Pneumonia merupakan penyakit infeksi saluran pernapasan akut yang menjadi masalah kesehatan di dunia karena angka kematiannya sangat tinggi pada anak di bawah usia 5 tahun (balita). Tujuan penelitian ini adalah mengetahui hubungan pemberian ASI ekslusif dan paparan rokok dengan kejadian pneumonia pada balita di RSUD Labuang Baji Makassar periode Januari 2018 – September 2019. Jenis penelitian ini adalah penelitian observasional analitik dengan pendekatan cross sectional. Metode pengambilan sampel adalah teknik total sampling sebanyak 112 responden yang diperoleh melalui wawancara menggunakan kuisioner kepada responden terkait pemberian ASI ekslusif dan paparan asap rokok. Hasil penelitian menunjukkan bahwa dari 112 sampel terdapat 48 balita (42,9%) telah diberikan ASI eksklusif dan 64 balita (57,1%) tidak diberikan ASI eksklusif. Sebagian besar balita mengalami pneumonia dalam penelitian ini terkena paparan asap rokok sebanyak 69 balita (61,6%). Kesimpulan : terdapat hubungan yang bermakna antara pemberian ASI eksklusif dan paparan asap rokok dengan kejadian pneumonia pada balita. Adapun saran yaitu diharapkan tenaga kesehatan dapat mengedukasi ibu untuk memberikan ASI eksklusif pada bayinya, melakukan program kampanye anti rokok dan diharapkan masyarakat berperan serta menurunkan angka kejadian pneumonia pada balita dengan memberikan asupan bergizi, ASI eksklusif dan berperilaku hidup bersih dan sehat.