bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of leadership in the digitalisation of manufacturing organisations
Authors: Tortorella Guilherme , Prashar Anupama , Antony Jiju , Mac Cawley Alejandro Francisco , Vassolo Roberto , Sony Michael 
Published: January 2023

PurposeThis study examines the moderating role of leadership behaviours on the relationship between Industry 4.0 (I4.0) maturity and operational performance in manufacturers.Design/methodology/approachFor that, 189 leaders from manufacturing organisations located in India and Brazil that are undergoing I4.0 implementation were surveyed. The collected data was analysed using multivariate data techniques, which allowed to verify the validity of our research hypotheses. This study was grounded on the concepts from the socio-technical systems (STS) theory.FindingsThe findings indicated that task-oriented leadership behaviours positively moderate the relationship between technologies for digitalisation and operational performance. A similar effect was found for the interaction between change-oriented leadership behaviours and strategy for digitalisation. In turn, the moderating effects of relations-oriented and change-oriented leadership behaviours were negative when considering the I4.0 maturity dimensions of employee and culture for digitalisation and technology for digitalisation, respectively.Originality/valueThis study offers arguments to better understand the role of leaders' behaviours in the digitalisation of organisations. Changing behaviours is usually a long-term and time-consuming activity. The identification of the leadership behaviours that are more likely to support digitalisation allows companies to anticipate potential issues and prioritise efforts to assertively develop leaders.
Long‐term effects of premenopausal risk‐reducing salpingo‐oophorectomy on cognition in women with high familial risk of ovarian cancer: A cross‐sectional study
Authors: Terra Lara , Lee Meeuw Kjoe Philippe R. , Agelink van Rentergem Joost A. , Beekman Maarten J. , Heemskerk‐Gerritsen Bernadette A. M. , van Beurden Marc , Roeters van Lennep Jeanine E. , van Doorn Helena C. , de Hullu Joanna A. , Mourits Marian J. E. , van Dorst Eleonora B. L. , Mom Constantijne H. , Slangen Brigitte F. M. , Gaarenstroom Katja N. , van der Kolk Lizet E. , Collée J. Margriet , Wevers Marijke R. , Ausems Margreet G. E. M. , van Engelen Klaartje , van de Beek Irma , Berger Lieke P. V. , van Asperen Christi J. , Gomez Garcia Encarna B. , Maas Angela H. E. M. , Hooning Maartje J. , van der Wall Elsken , van Leeuwen Flora E. , Schagen Sanne B. 
Published: January 2023

AbstractObjectiveTo examine the effect of a premenopausal risk‐reducing salpingo‐oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO.DesignA cross‐sectional study with prospective follow‐up, nested in a nationwide cohort.SettingMulticentre in the Netherlands.Population or Sample641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment.MethodsParticipants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression.Main Outcome MeasuresThe influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO.ResultsAfter adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years).ConclusionsReassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.
Comprehensive needle and syringe program and opioid agonist therapy reduce HIV and hepatitis c virus acquisition among people who inject drugs in different settings: A pooled analysis of emulated trials
Authors: van Santen Daniela K. , Lodi Sara , Dietze Paul , van den Boom Wijnand , Hayashi Kanna , Dong Huiru , Cui Zishan , Maher Lisa , Hickman Matthew , Boyd Anders , Prins Maria 
Published: January 2023

AbstractBackground and AimsAlthough the Netherlands, Canada and Australia were early adopters of harm reduction for people who inject drugs (PWID), their respective HIV and hepatitis C (HCV) epidemics differ. We measured the pooled effect of needle and syringe program (NSP) and opioid agonist therapy (OAT) participation on HIV and HCV incidence in these settings.DesignFor each cohort, we emulated the design and statistical analysis of a target trial using observational data.Setting and ParticipantsWe included PWID at risk of HIV or HCV infection from the Amsterdam Cohort Studies (1985–2013), Vancouver Injection Drug Users Study (1997–2009) and Melbourne Injecting Drug User Cohort Study (SuperMIX) (2010–2021).MeasurementsSeparately for each infection and cohort (only HCV in SuperMIX), marginal structural models were used to compare the effect of comprehensive (on OAT and 100% NSP coverage or on OAT only if no recent injection drug use) versus no/partial NSP/OAT (no OAT and/or <100% NSP coverage) participation. Pooled hazard ratios (HR) and 95% CI were calculated using random‐effects meta‐analysis.FindingsWe observed 94 HIV seroconversions and 81 HCV seroconversions among 2023 and 430 participants, respectively. Comprehensive NSP/OAT led to a 41% lower risk of HIV acquisition (pooled HR = 0.59, 95% CI = 0.36–0.96) and a 76% lower risk of HCV acquisition (pooled HR = 0.24, 95% CI = 0.11–0.51), compared with no/partial NSP/OAT, with little heterogeneity between studies for both infections (I2 = 0%).ConclusionsIn the Netherlands, Canada and Australia, comprehensive needle and syringe program and opioid agonist therapy participation appears to substantially reduce HIV and hepatitis C acquisition compared with no or partial needle and syringe program/opioid agonist therapy participation. These findings from an emulated trial design reinforce the critical role of comprehensive access to harm reduction in optimizing infection prevention for people who inject drugs.
Letter: improve survival after variceal bleeding in cirrhosis—place pTIPS as early as possible after index bleed
Authors: Rudler Marika , Hernandez‐Gea Virginia , Thabut Dominique , Garcia‐Pagan Juan‐Carlos 
Published: January 2023

LINKED CONTENTThis article is linked to Dunne et al papers. To view these articles, visit https://doi.org/10.1111/apt.17252 and https://doi.org/10.1111/apt.17372
Lived experience research in learning disabilities: The understanding inequalities project from a service user's perspective
Authors: Gray Ben , Kerridge Tom 
Published: January 2023

AbstractBackgroundPeople with learning disabilities are often left behind and ostracised in life, education, employment and in research. This article describes the importance and value that people with learning disabilities can bring when participating in co‐production and lived experience research. The article reports on the inequalities and barriers that people living with learning disabilities have in accessing health and social care services and hospitals and makes recommendations for improving services and people's experiences of services. The intertwining of subject (inequalities and barriers of access) and process (lived experience research and co‐production) leads to more comprehensive knowledge and understanding of learning disabilities.MethodsCo‐production events were held with people with learning disabilities, facilitated by the co‐author (Tom Kerridge). Tom and a service user researcher (Ben Gray) with Asperger's syndrome and schizophrenia thematised transcripts and made recommendations, in Ben's case with the insight of lived experience of learning disabilities and mental health problems.FindingsA series of recommendations are made based on the insight of a lived experience perspective. For example: to have a grass roots learning disabilities champion, lived experience peer mentors and supporters, training via a film made by people with learning disabilities, the involvement of Learning Disabilities Research Ambassadors to conduct phase two of the research as well as other recommendations.ConclusionsLived experience research and co‐production are at the heart and centre of contemporary research in health and social care. Participation can change feelings of exclusion and stigma into feelings of being valued, accepted and being able to make a difference.
Immune response elicited in the tumor microenvironment upon rMV‐SLAMblind cancer virotherapy
Authors: Moritoh Kanako , Shoji Koichiro , Amagai Yosuke , Fujiyuki Tomoko , Sato Hiroki , Yoneda Misako , Kai Chieko 
Published: January 2023

AbstractOncolytic virotherapy is a promising therapy for cancer. We previously established a recombinant measles virus (rMV‐SLAMblind) that targets NECTIN4‐expressing cancer cells and demonstrated its antitumor effects using a xenograft model in an immunodeficient mouse. In the current study, to investigate the immune response after rMV‐SLAMblind therapy, we developed an immunocompetent cancer mouse model by introducing the NECTIN4 gene into mouse cancer cell lines. NECTIN4‐expressing mouse cancer cells were successfully killed by rMV‐SLAMblind in vitro. After transplantation of the NECTIN4‐expressing tumor cells, rMV‐SLAMblind significantly suppressed tumor growth in immunocompetent mice. Thus, this immunocompetent mouse cancer model could be a powerful tool in which to study the effect of rMV‐SLAMblind therapy on the immune response. Using this model we found that rMV‐SLAMblind elicited significant activation of natural killer cells, type 1 helper T cells and the tumor‐specific CD8+ T‐cell response in the tumor microenvironment. Immune cell depletion study revealed that CD8+ cells particularly played significant roles in the therapeutic efficacy of rMV‐SLAMblind. Thus, rMV‐SLAMblind exerts a therapeutic effect, not only directly by tumor cell killing, but also indirectly by efficient induction of antitumor immunity.
COVID‐19‐related adrenal haemorrhage: Multicentre UK experience and systematic review of the literature
Authors: Elhassan Yasir S. , Iqbal Fizzah , Arlt Wiebke , Baldeweg Stephanie E. , Levy Miles , Stewart Paul M. , Wass John , Pavord Sue , Aled Rees D. , Ronchi Cristina L. 
Published: January 2023

AbstractObjectiveAdrenal haemorrhage (AH) is an uncommon, usually incidental imaging finding in acutely unwell patients. AH has been reported during coronavirus disease 2019 (COVID‐19) infection and following ChAdOx1 nCoV‐19 (Oxford‐AstraZeneca) vaccination. The Society for Endocrinology (SfE) established a task force to describe the UK experience of COVID‐19‐related AH.DesignA systematic literature review was undertaken. A survey was conducted through the SfE clinical membership to identify patients with COVID‐19‐related AH using a standardized data collection tool.ResultsThe literature search yielded 25 cases of COVID‐19‐related AH (19 bilateral; 13 infection‐related, and 12 vaccine‐related). Eight UK centres responded to the survey with at least one case. A total of 18 cases were included in the descriptive study, including 11 from the survey and 7 UK‐based patients from the systematic review. Seven patients (4 males; median age 53 (range 26–70) years), had infection‐related AH (four bilateral). Median time from positive COVID‐19 test to AH detection was 8 (range 1–30) days. Eleven cases of vaccine‐related AH (eight bilateral) were captured (3 males; median age 47 (range 23–78) years). Median time between vaccination (nine Oxford‐AstraZeneca and two Pfizer‐BioNTech) and AH was 9 (range 2–27) days; 9/11 AH occurred after the first vaccine dose. Acute abdominal pain was the commonest presentation (72%) in AH of any cause. All 12 patients with bilateral AH and one patient with unilateral AH required glucocorticoid replacement.ConclusionAdrenal haemorrhage with consequential adrenal insufficiency can be a complication of COVID‐19 infection and vaccination. Adrenal function assessment is mandatory to avoid the potentially fatal consequences of unrecognized adrenal insufficiency.
Black summer bushfires caused extensive damage to estuarine wetlands in New South Wales, Australia
Authors: Glasby Tim M. , Gibson Peter T. , Laird Roger , Swadling Daniel S. , West Gregory 
Published: January 2023

SummaryThere is now considerable evidence that, as the climate continues to warm, bushfires are becoming more common and severe, particularly in regions such as south‐eastern Australia. The extraordinary Australian bushfires over the summer of 2019/2020 resulted in the burning of habitats such as highland peat swamps and intertidal estuarine wetlands over unprecedented spatial scales. Across New South Wales, these bushfires affected 183 ha of saltmarshes and 23 ha of mangroves in 19 estuaries. The percentage of fire‐affected saltmarsh ranged from 51% to 81% in the worst impacted estuaries, although typically ≤15% of mapped saltmarsh was damaged. Just over 50% of mangroves were burnt in Wonboyn Lake (although this constituted <0.2 ha), whereas in all other estuaries, ≤5% of mangroves were burnt. At the state‐wide scale, the likelihood of saltmarshes being affected by fire was unrelated to adjacent terrestrial vegetation; however, mangroves adjacent to burnt wet sclerophyll forest were more likely to burn than not. Burnt mangroves were almost exclusively associated with extreme or high severity fires in adjacent terrestrial vegetation, yet saltmarshes were also impacted in some cases by moderate or low‐intensity fires. Many species of saltmarsh plants had re‐sprouted or germinated after 6–24 months, but the extent of any recovery or changes in species composition were not quantified. The majority of fire‐affected mangrove trees appeared to be dead 24 months after the fires, despite observations of epicormic growth on some trees after six months. Bushfire impacts to estuarine wetlands are likely to become more frequent and results from our work can help target hazard reduction burning that might be considered for minimising damage to mangroves. More work is required to better understand potential longer term impacts and the capacity for natural recovery of estuarine wetlands from bushfires.
Holistic and mechanical combination in psychological assessment: Why algorithms are underutilized and what is needed to increase their use
Authors: Neumann Marvin , Niessen A. Susan M. , Hurks Petra P. M. , Meijer Rob R. 
Published: January 2023

AbstractAlthough mechanical combination results in more valid human performance predictions and decisions than holistic combination, existing publications suggest that mechanical combination is rarely used in practice. Yet, these publications are either descriptions of anecdotal experiences or outdated surveys. Therefore, in several Western countries, we conducted two surveys (total N = 323) and two focus groups to investigate (1) how decision makers in psychological assessment and human resource practice combine information, (2) why they do (not) use mechanical combination, and (3) what may be needed to increase its use in practice. Many participants reported mostly using holistic combination, usually in teams. The most common reasons for not using mechanical combination were that algorithms are unavailable in practice and that stakeholders do not accept their use. Furthermore, decision makers do not quantify information, do not believe in research findings on evidence‐based decision making, and think that combining holistic and mechanical combination results in the best decisions. The most important reason why mechanical combination is used was to increase predictive validity. To stimulate the use of mechanical combination in practice, decision makers indicated that they should receive more training on evidence‐based decision making and that decision aids supporting the use of mechanical combination should be developed.
Effects of different shallow and saline groundwater depths on soil salinity, evapotranspiration, grain yield and spike traits of winter wheat
Authors: Kiremit Mehmet Sait , Arslan Hakan 
Published: January 2023

AbstractThe contribution of groundwater to evapotranspiration in crop irrigation scheduling is gaining importance worldwide. A two consecutive year wheat experiment was conducted in drainable lysimeters to evaluate the response of grain yield and quality, spike traits, water use efficiency, evapotranspiration and thousand kernel weight of wheat plants under twelve different shallow and saline groundwater conditions. The treatments included three groundwater depths (GWD) (D1: 30 cm, D2: 55 cm and D3: 80 cm) and four groundwater salinities (GWS) (S1: 0.38, S2: 2, S3: 4 and S4: 8 dSm−1). The results show that the average decrease in grain yield for D2and D1compared to D3was 20.9% and 30.7%, respectively, while the decrease for S2, S3and S4compared to S1was 11.8%, 18.0% and 25.1%. The highest evapotranspiration was found in the D3S1treatment (630.1 and 550.1 mm in 2017–2018 and 2018–2019, respectively), which increased by 48.0% and 30.2% in the first and second seasons, respectively, compared to the D1S4treatment. Thus, a GWD at 80 cm with 0.38 dSm−1GWS was able to meet 72% of the total water requirement of wheat under loam soil conditions. Water use efficiency values ranged from 1.49 to 1.65 kg m−3in the first season and from 1.18 to 1.73 kg m−3in the second season, with the highest water use efficiency values found at 80 cm GWD. Regression analysis showed that GWS had a greater effect on water use efficiency than GWD. On average, thousand kernel and hectolitre weights were highest under D3S1, reaching 49.6 g and 77.8 kg hl−1, respectively. Soil salinity increased steadily with increasing GWS at all GWD conditions, and higher soil salinity values were observed at 30 cm GWD. In addition, controlling a groundwater depth at 80 cm with 8.0 dSm−1GWS did not significantly increase soil salinity, which did not result in high grain yield losses. Finally, it is recommended to control groundwater at a constant depth of 80 cm with 0.38 dSm−1GWS after the tillering period of winter wheat to save more irrigation water, control soil salinity and improve yield and grain quality in the region with shallow‐saline groundwater.
COVID‐19 and Dr. Google: Parents' changing experience using online health information about their children's health during the pandemic
Authors: Negrone Ashlee J , Caldwell Patrina HY , Scott Karen M 
Published: January 2023

AimsTo identify how the COVID‐19 pandemic influences parents' use of the internet, including social media, when seeking health‐related information about the pandemic relevant to their children.MethodsThis study employed semi‐structured interviews to explore the factors affecting parents of young children when information‐seeking online about their children's health related to the COVID‐19 pandemic. Parents of children with and without chronic health conditions were interviewed in July and August 2020. Interviews were audio‐recorded and transcribed verbatim, then analysed using theoretical thematic analysis, based on Social Cognitive Theory.ResultsThrough interviews with 13 parents, we identified a myriad of factors that affected parents' internet searching. The decision to access online health information and the regulation of its usage was multifaceted and relied upon the interactions between environmental triggers and parents' information needs, personal attitudes, and circumstances. Overall, parents felt supported by online health information during the COVID‐19 pandemic, and the majority were confident in their ability to navigate the plethora of online health information. However, parents of children with chronic conditions had unmet information needs in relation to COVID‐19 and their children's condition.ConclusionsUnderstanding parents' attitudes and behaviours when seeking online health information that is relevant to their children during a global pandemic can inform the optimisation of online health content delivery to parents.
Minor painful procedures in extremely preterm infants admitted to a tertiary neonatal intensive care unit: Opportunities to improve pain mitigation
Authors: Fulkoski Nick , Kecskes Zsuzsoka , Chaudhari Tejasvi 
Published: January 2023

AimThis study aims to characterise current pain management practices in extremely preterm infants (gestational age less than or equal to 28 weeks) admitted to neonatal intensive care unit (NICU).MethodsRetrospective audit pertaining to patient characteristics, as well as minor painful procedures (MPP), pain mitigation and pain scoring in 25 extremely preterm infants admitted to a tertiary NICU in 2016 over the first 14 days of NICU admission. Opportunities to bundle MPP were identified according to pre‐specified criteria. Bayley Scales of Infant Development, Third Edition (BSID‐III) cognitive, language and motor composite scores were available from the neurodevelopmental follow‐up clinic at 12‐ and 24‐months of corrected age. Linear mixed methods regression was used to examine for correlation between increased exposure to MPP and BSID‐III scores at follow‐up.ResultsExtremely preterm infants underwent an average of 11.24 ± 4.12 MPP per day for the first 14 days of NICU admission. Opportunities to bundle MPP were missed 75.98% (408/537) of the time; most of these were invasive blood collections. A total of 12.2% (481/3933) of MPP occurred within 4 h of pharmacological or non‐pharmacological pain mitigation. BSID‐III motor composite score was associated with an 11.75 (95% confidence interval 1.99, 21.27) decrease in patients experiencing more than or equal to the third quartile of MPP in the 14 days post‐NICU admission (P = 0.0329, n = 42). Association was not found for BSID‐III cognitive and language composite scores.ConclusionsThere is readily scope for quality improvement initiatives to reduce harm in extremely preterm infants admitted to NICU.
Premature R&D alliance termination and shareholder returns: Evidence from the biopharmaceutical industry
Authors: Eslami Hadi , Eshghi Kamran , Sadeh Farhad 
Published: January 2023

AbstractPrior research has highlighted the performance implications of R&D alliances for innovation outcomes and the financial returns of firms. However, research on R&D alliances has yet to offer insights into how the premature termination of such alliances, before fulfilling their predetermined innovation objectives, affects the shareholder returns of the firm. Applying transaction cost economics (TCE) theory and real options (RO) logic to a post‐formation alliance setting, we posit that premature termination of R&D alliances prompts relative volatility in investors' prospective benefits and risks. Employing an event study analysis method and using a sample of 116 premature alliance termination announcements in the biopharmaceutical industry, we observe an average negative abnormal stock return of 3.21% for focal firms. Further, our analyses reveal that investors respond even more adversely to alliances terminated unilaterally by the partner of the focal firm in which they invested than those terminated through mutual agreements or by the focal firm itself. Also, we find that alliance duration from formation to termination mitigates the negative effect of termination on shareholder returns.