bluuebunny/crossref_metadata_2025_split huggingface dataset:
Size, Surface Properties, and Ion Release of Zinc Oxide NPs: Effects on Cytotoxicity, Dopaminergic Gene Expression, and Acetylcholinesterase Inhibition in Neuronal PC-12 Cells
Authors: Suthar Jitendra Kumar , Vaidya Anuradha , Ravindran Selvan 
Published: July 2023

Abstract
The extensive applications of Zinc Oxide NPs (ZnO NPs) have resulted in a substantial risk of human exposure via multiple routes of exposure. However, the knowledge of the toxicity of these NPs in nervous system is still limited. A comparative analysis of ZnO NPs of various sizes and NPs of the same size, with and without surface coating, and the potential role of released zinc ions is yet to be thoroughly explored. As a result, we have studied the cellular toxicity of two different-sized ZnO NPs, ZnO-22 (22nm) and ZnO-43 (43nm), and NPs with similar size but with polyvinylpyrrolidone surface coating (ZnO-P, 45nm) with different concentrations. The findings from our study suggested a time, size, and surface coating-dependent cytotoxicity in neural PC-12 cells at a concentration ≥10μg/ml. ZnO NPs treatment significantly increased reactive oxygen and reactive nitrogen species, leading to increased oxidative stress in the neural cells. PC-12 cells' expression of certain genes associated with the dopaminergic system were also investigated. The exposure of ZnO-22 and ZnO-43 significantly upregulated the expression of Monoamine oxidase A and downregulated the expression of the α-synuclein gene. The interaction of NPs with proteins and enzymes in the nervous system is also hazardous. Therefore, acetylcholinesterase enzyme being one such enzyme was also studied for its interaction with these NPs, and results indicated a dose-dependent inhibition of enzyme activity. Furthermore, the study of released zinc ions from the NPs suggested no significant contribution to the observed cytotoxicity compared to the NPs itself.
Magneto-hydrodynamic peristaltic flow of a Jeffery fluid in the presence of heat transfer through a porous medium in an asymmetric channel
Authors: Abd-Alla A. M. , Abo-Dahab Sayed , Salah Doaa. M. , Abdelhafez M. A. 
Published: July 2023

Abstract
This work finds application in porous-fabrication techniques and the chemical industry. This study examines the effects of the magnetic field and heat transfer on peristaltic flow of a Jeffery fluid conveying through an asymmetric channel. The problem is modelled with the aid of a long wavelengths and low Reynolds numbers. The expressions for velocity, temperature, pressure gradient and streamlines are derived using the hypothesis of a long wavelength. Numerical integration is used to estimate both the frictional force and pressure increase. The physical parameters are analysed and discussed graphically and find their physical meaning. The significant outcome of this work is to analyze the flow behaviour in an asymmetric channels. The results of this study can be used to improve pumping mechanisms in engineering and to improve gastrointestinal functions. This analysis allows bodily fluids such as blood and lymph to circulate freely within the arteries and vessels, facilitating the delivery of oxygen, waste excretion, and other essential substances.
Inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T&gt;C (rs11706052) and 12-month evolution of the graft function in renal transplant recipients on mycophenolate-based immunosuppression
Authors: Trkulja Vladimir , Penezić Luka , Škegro Sandra Nađ , Hadžavdić Ayla , Ganoci Lana , Kaštelan Željko , Božina Nada 
Published: July 2023

Abstract

Variant allele at the inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T > C has been associated with increased enzyme activity and reduced susceptibility to mycophenolic acid (MPA) in vitro. It has been suggested associated with an increased risk of acute rejection in renal transplant recipients on MPA-based immunosuppression, but not unambiguously. We assessed one-year evolution of the estimated glomerular filtration rate (eGFR) in 52 variant carriers and 202 wild-type controls exposed to MPA. Adjusted for a range of demographic, pharmacogenetic, (co)morbidity, and treatment baseline and time-varying covariates, the eGFR slopes to day 28 (GMR = 1.01, 95%CI 0.93–1.09), and between days 28 and 365 (GMR = 1.01, 95%CI 0.99–1.02) were practically identical in variant carriers and wild-type controls. The estimates (95%CIs) remained within the limits of ±20% difference even after adjustment for a strong hypothetical effect of unmeasured confounders. Polymorphism IMPDH2 3757T > C does not affect the renal graft function over the 1st year after transplantation.
Relative contribution of top-down and bottom-up controls on the regulation of the sponge Hymeniacidon perlevis (Montagu, 1814) in Patagonia: an experimental and observational approach.
Authors: Buch Macarena Marello , Gastaldi Marianela , Abrameto Mariza , Firstater Fausto Nahuel 
Published: July 2023

Abstract
Two main perspectives explain the structure of food webs: bottom-up and top-down controls, respectively driven by trophic resources and consumption pressure. There is evidence of the relative contribution of both controls over sponges in tropical environments, but it is still unknown how these controls mediate the regulation of sponge populations in temperate environments. To assess this, we performed in situ manipulative experiments and samplings on the worldwide-distributed sponge Hymeniacidon perlevis in two tidal channels from San Antonio Bay (Argentine Patagonia), with different anthropic nutrients loads. We first experimentally tested the relative contribution of the top-down and bottom-up controls on the individual sponge growth. Then, we identified the consumers of H. perlevis, assessing their consumption pressure. Finally, we assessed the abundance of H. perlevis and the concentration of particulate and dissolved trophic resources for the sponge at both tidal channels. We found that H. perlevis was more abundant and grew more in the channel with the highest concentration of trophic resources, despite the consumption pressure of several consumers (ophiuroids, polychaetes, crabs and fishes). Among the available trophic resources, nitrate, phosphate and total suspended solids best explained the abundance pattern of H. perlevis throughout a year. Our results show that the abundance and individual growth of H. perlevis is mostly bottom-up controlled, through particulate but mainly dissolved trophic resources. The role of a symbiotic pathway in the fulfillment of the nutritional requirements of H. perlevis is also discussed.
Translation Surfaces of Finite Type Regardingthe Third Fundamental Form
Authors: Alzaareer Hamza , AL-ZOUBI Hassan 
Published: July 2023

Abstract
Translational surfaces in 3-dimensional Euclidean space (E3) areused in various fields, such as differential geometry, computer graphics, andmaterial science. Studying the properties of these surfaces play an essential rolein developing algorithms that can efficiently analyze and manipulate them. Inthis article, we explore the third fundamental form of the translation surfaces.Notably, we find that Sherk’s surface is the only translation surface of thefinite Chen type regarding the third fundamental form.
SCF-MAC Protocol: A selective node’s-waking up, collision-alleviating, fault- tolerant medium access protocol for Linear Wireless Sensor Network
Authors: Mann Mamta , Singh Rishipal 
Published: July 2023

Abstract
Linear sensor network is becoming an interesting area of research due to its distinctive characteristic of linearity. Also, when it comes to monitoring and surveillance task, LSNs are of great importance. However, the battery constraint nature of sensor network act as a limiting factor, thus making energy efficiency an essential requirement for designing LSNs. In context of the seven-layer approach, Mac layer is considered to be the most essential layer for energy conservation. In this paper, we have proposed a Mac protocol specifically for LSN which is divided into homogeneous grades having sink node at one end only. It is a synchronous duty-cycled protocol utilizing pipeline forwarding or staggered scheduling along with a fault tolerance mechanism to overcome load balancing issues. Extensive discrete time simulations have been performed which shows that SCF MAC have remarkably performed better than the previous state of art models in terms of throughput, packet drop probability, energy consumption.
Study of catalytic properties and grinding performance of single-crystal SiC heterogeneous Fenton reaction grinding discs
Authors: Hu Da , Lu Jiabin , Li Huilong , Cao Jiyang , Yan Qiusheng 
Published: July 2023

Abstract

This study proposes an ultra-precision processing method based on the heterogeneous Fenton reaction of grinding discs to improve the grinding efficiency of single-crystal SiC via a chemical reaction. Ceramic-bonded grinding discs with heterogeneous Fenton reaction were prepared, and the influence of the chemical reaction parameters on the catalytic properties of the discs as well as the grinding effect of single-crystal SiC under different grinding parameters were investigated and the grinding mechanism was analysed. The results indicate that the higher the mass fraction of H2O2, the stronger the catalytic properties. The maximum material removal rate (MRR) (43.13 nm/min) and the lowest surface roughness (Ra 1.06 nm) were obtained at 20 wt.%. Moreover, the lower the pH value, the stronger the catalytic properties of the grinding solution and the larger the MRR; however, the best grinding surface quality was obtained at pH = 3. The MRR increased with the grinding pressure, and the surface quality was superior at a pressure of 62.4 kPa. The MRR also increased with increasing disc speed, yielding a low surface roughness at a speed of 200 rpm. The mechanical and chemical effects are balanced to improve the surface quality of SiC. The Fenton reaction grinding disc oxidises the SiC surface to form an oxide layer of SiO2; subsequently, the mechanical action of the abrasive removes the oxide layer, exposing a new SiC surface where oxidation and material removal continue to occur. This cyclical process enables the efficient grinding of single-crystal SiC.
A Novel Ferroptosis-Related Gene Signature for Chemotherapy Resistance Prediction in Triple-negative Breast Cancer
Authors: You Huan , Qian Hongyan , Miao Shichen , Li Xuan , Liu Bingyi , Zhang Dan , Chen Yanpeng , Ni Qichao , Sheng Chenyi 
Published: July 2023

Abstract
Taxanes are first-line chemotherapeutic agents for patients with triple-negative breast cancer (TNBC). However, resistance, the main cause of clinical treatment failure and poor prognosis, reduces their effectiveness and has become an increasingly important problem. Recently, a form of iron-dependent programmed cell death called ferroptosis was reported to play an important role in regulating tumor biological behavior. In this study, we revealed the prognostic significance of the ferroptosis‑related gene (FERG) model and clarified that ferroptosis-related genes may be promising candidate biomarkers in cancer therapy. First, resistance-related FERGs were screened, and univariate Cox regression analysis was used to construct a prognostic model, including GRIK3, IDO1, and CLGN. Then, the patients with TNBC in the TCGA database were classified into high-risk and low-risk groups. The identification of TNBC in the TCGA database revealed that patients with high scores had a higher probability of dying earlier than those with low scores. Moreover, these three genes were associated with immune infiltrates and checkpoints in TNBC patients. In conclusion, this study suggested that FERGs are significantly associated with chemotherapy resistance in patients with TNBC and that these genes can be used as prognostic predictors in these patients and possibly for targeted therapy in the future.
Altered mitochondrial dynamics in chondrocytes cause metabolic reprogramming and influence HIF-2 alpha expression in osteoarthritis
Authors: wang Chenzhong , Yang Yi , Liu Bo , Wan Shengcheng , Yao Zhenjun , Zhang Ying , Zhang Chi 
Published: July 2023

Abstract

This study investigated the relationship between mitochondrial dynamics, cell metabolism and extracellular matrix metabolism in chondrocytes to evaluate contribution of mitochondrial dynamics to the development of osteoarthritis (OA). Dynamin-related protein (DRP) 1 and optic atrophy (OPA)1 expression were examined in cartilage from surgical specimens and mouse models. Functional analyses were carried out by short interfering RNA-mediated knockdown of DRP1 and OPA1 in cultured spheroids. Seahorse XF96 assay to determine metabolism state of chondrocytes. RNA-seq was performed to find potential mechanism in OPA1-/- chondrocytes. OA progression was assessed by OA score, immunohistochemistry and micro-CT analysis after destabilizing the medial meniscus surgery with intra-articular injection of adeno-associated virus. DRP1 was markedly downregulated while OPA1 was upregulated in OA cartilage compared to healthy cartilage of human and mice knee joint. DRP1 knockdown in chondrocytes resulted in the formation of megamitochondria, and OPA1 knockdown resulted in the increased fragmented mitochondria of. Both knockdown of DRP1 and OPA1 restored the normal mitochondrial morphology. Loss of OPA1 inhibited cartilage degradation and promoted chondrocyte extracellular matrix synthesis while DRP1 knockdown had the opposite effects; cartilage homeostasis was restored in chondrocytes lacking both DRP1 and OPA1. IL-1β causing a shift from oxidative phosphorylation to glycolysis in chondrocytes, which was reversed by OPA1 depletion. OPA1 knockdown downregulated HIF-2α mRNA and protein level and protected mice against OA. Perturbation of mitochondrial dynamics in chondrocytes contributes to cartilage destruction and the progression of OA. These data identify OPA1 as a therapeutic target in OA.
Flood risk assessment using GIS- MCDM-AHP model: case of the Wadi Chafrou watershed (Northern Tunisia)
Authors: Baccari Noamen , Sebei Abdelaziz , Soussi Dhekra , Zouhri Lahcen , Saidi Salwa 
Published: July 2023

Abstract

Inundations represent one of the most impactful and hazardous natural disasters, leading to extensive loss of life and property. The establishment of flood susceptibility map is highly needed for risk prevention. This research takes Chafrou watershed, NE Tunisia as the study area. Five influencing criteria including Rainfall, Land use/Land cover, Slope, lithology and Streams Network was selected and processed utilizing GIS based on Multi-criteria Decision Making model (MCDM) via the analytical hierarchy process (AHP) method to carry out the flood hazard susceptibility model and estimated the Flood Hazard potential Index (FHI). The approach used in the weight calculation is the prioritized by pairwise comparison (PWC).
The application of the proposed approach shows that the land use / Land cover is the most influencing parameter flooding with weight order 35%, followed by the Slope (27%). The flood susceptibility model elaborated shows that the study area is subdivided in five categories: areas with very high risk of flooding which cover (11%) of the total surface of the basin, high risk areas (13%), moderate risk zones (24%), low hazard areas (26%) and very low hazard areas (26%). The validation of results by GIS-MCDM-AHP flood susceptibility histogram method is more than 73%, so the prediction effect is excellent. The results of this research are valuable to determine the interplay between flood and influencing criteria’s in Chafrou watershed, which could be used as a guide for the flood susceptibility evaluation and can supply a data basis for catastrophes prevention and mitigation for NE of Tunisia.
The Estimating Level of Awareness and Knowledge of Colorectal Cancer Among General Population in Al-Ahsa Region, Saudi Arabia
Authors: Alali Mohammed , Alessa Mohammed , Alturaiki Hassan , Alkuaybi Fatimah , Alabbad Noora , Buali Fatimah , Alqattan Jumanah , Alabdullah Zainab , Almumtin Khulud , Albinsaad Loai 
Published: July 2023

Abstract
Introduction: Colorectal cancer (CRC) is a type of cancer that affects the colon. Globally, CRC is one of the most common types of cancer in the world among both genders. The east of Saudi Arabia, Al Ahsa, is reported by the Saudi Cancer Registry to have the highest incidence. Most patients seek medical help in a late stage of this disease with a survival rate lower than the survival rate all over the world. Aim: This study aimed to assess the knowledge and awareness of CRC signs and symptoms among the general population in Alahsa. Methods: This cross-sectional study was conducted from August 2022 to February 2023 targeted general population in Alahsa region of Saudi Arabia. Result: 385 out of 457 of the participants which is represented as 84% answered the questionnaire correctly. Conclusion: There is an excellent level of awareness of colorectal cancer signs and symptoms among general population in Alahsa. This reflects the excellent knowledge and education among the general .population. Leading us to expect an early medical help seek if anyone experienced colorectal cancer symptoms
Estimating Missing Hydrological Data using Group Method of Data Handling (GMDH) in Mahanadi Basin, India
Authors: Malhotra Karishma Bhatnagar , Nema Arvind Kumar 
Published: July 2023

Abstract

High-quality hydrological data is essential for a wide range of applications, including the planning, design, operation, and maintenance of multipurpose water resource projects. It also plays a crucial role in utilizing various modelling and statistical methods for flood prediction and management, conducting hydrological analyses, estimating and monitoring environmental flows, as well as supporting research and development efforts. Hydrological data comprising of river Gauge (G), Discharge (D), Sediment (S) and Quality (Q) are collected at daily, weekly, ten-daily or monthly frequencies using either manual entry procedures or automatic measurement systems at hydrological observations sites. These are stored in databases that are made available to researchers, water managers etc for planning and research purposes. Missing data is a common problem in numerous hydrological databases that leads to inaccurate results, reducing statistical power and reliability of the data. Missing data also affects statistical analysis thereby reducing reliability and modelling conclusions drawn from using these incomplete datasets. To address this problem, the Group Method of Data Handling (GMDH) approach is applied to analyze data matrices from four hydrological observation sites in the Mahanadi River Basin, India. The daily discharge data is split into a learning set (70%) and a training set (30%) for the GMDH model. The Coefficients of determination (R2), Root Mean Square Error (RMSE) and Mean Absolute Error (MAE) was used to evaluate the performance of GMDH model. The results illustrated the successful application of the GMDH algorithm in addressing missing data issues within discharge data, effectively filling the gaps.
Implementation feasibility of Animal Assisted Therapy in a Paediatric Intensive Care Unit
Authors: Fernandez Eduardo López , Cuesta Alba Palacios , Martínez Alicia Rodríguez , Jodar Marta Olmedilla , Andrade Rocio Fernández , Fernandez Raquel Mediavilla , Díaz Juan Ignacio Sánchez , Máximo-Bocanegra Nuria 
Published: July 2023

Abstract
Purpose: Animal assisted therapies are an innovative strategy within health care humanisation initiatives, and they could play a role in the reduction of pain or anxiety. The main objective of this work was to evaluate the feasibility of implementing animal assisted therapy in a Paediatric Intensive Care Unit.
Methods: A prospective, non-randomized study of Animal Assisted Therapy was designed in the Paediatric Intensive Care Unit of the Hospital Universitario 12 de Octubre of Madrid, from January 2019 to December 2019. The study sample included patients who had been admitted to the unit and were over three years old.
Satisfaction surveys were collected from the patients, family and health personnel involved. Physiological variables and the level of pain, (Visual Analogue Scale or Wong Baker scale) fear (Child Medical Fear Scale), and anxiety (modified Yale Anxiety Preoperatory Scale), were evaluated before and after each session. Any existence of adverse events was recorded.
Results: A total of 74 Therapy sessions were performed on 61 patients. All sessions were completed without any adverse effects. 164 surveys were collected, providing an overall project rating of 9.69 out of a possible 10. The survey comments were found to be positive in most cases. No differences were found in the physiological variables measured before and after each session. There was a statistically significant decrease (p <0.01) in pain, fear, and anxiety levels.
Conclusions: The implementation of an animal-assisted therapy project in a Paediatric Intensive Care Unit is feasible, safe and has a high degree of acceptance among both participants and healthcare staff. It could therefore be considered as an alternative non-pharmacological therapy for the reduction of pain, fear, or anxiety.
Assessment of vessel deformation using deep learning-based semantic segmentation algorithm during needle manipulation in microvascular anastomosis: A pilot study
Authors: Tang Minghui , Sugiyama Taku , Takahari Ren , Sugimori Hiroyuki , Yoshimura Takaaki , Ogasawara Katsuhiko , Kudo Kohsuke , Fujimura Miki 
Published: July 2023

Abstract

Appropriate needle manipulation to avoid abrupt deformation of fragile vessels is a critical determinant of the success of microvascular anastomosis. However, no studies have evaluated the shape and area of the surgical objects. The present study aimed to develop a deep learning-based semantic segmentation algorithm and to assess vessel deformation in microvascular anastomosis for objective surgical skill assessment of "respect for tissue.” Semantic segmentation algorithm was trained based on a ResNet-50 network using microvascular end-to-side anastomosis training videos with artificial blood vessels. Using the created model, tissue deformation was analyzed, and the threshold violation error numbers were compared between expert and novice surgeons during the completion task of one stitch. High validation accuracy (99.1%) and Intersection over Union (0.93) were obtained for the auto-segmentation model. While completing the one-stitch task, experts showed significantly fewer errors than novices (p < 0.001), with a shorter completion time (p < 0.001). Significant differences were also observed in the phase of needle insertion (p = 0.04) and needle extraction (p < 0.001) between experts and novices. In conclusion, the assessment of vessel deformation during microvascular anastomosis using a deep-learning-based semantic segmentation algorithm is presented as a novel concept for evaluating microsurgical performance. This will be useful for future computer-aided devices to enhance surgical education and patient safety.
In-situ pixel wise emissivity measurement using a multispectral infrared camera
Authors: Poissenot-Arrigoni Corentin , Marcon Bertrand , Rossi Frederic , Fromentin Guillaume 
Published: July 2023

Abstract
In the thermography process, accurately determining emissivity is crucial for obtaining precise temperature measurements as it enables the conversion of radiometric values to absolute temperatures. However, assessing emissivity is not a straightforward task as it depends on various other parameters. Traditional methods for measuring emissivity often involve costly materials and cannot be carried out simultaneously with infrared image acquisition. This article presents a method for obtaining pixel-wise emissivity using data from a multispectral infrared camera. Consequently, this method allows for direct emissivity measurement during infrared camera acquisition without the need for additional materials or experiments.