bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism
Authors: Filatova V. A. , Rozhivanov R. V. , Bondarenko I. Z. , Ioutsi V. A. , Andreeva E. N. , Mel’nichenko G. A. , Mokrysheva N. G. 
Published: May 2023

AIM. To reveal the peculiarities of steroidogenesis and arterial hypertension in «physiological» hyperandrogenism in men.MATERIALS AND METHODS. One-stage simultaneous study. The groups of men with hyperandrogenism caused by increased total testosterone (n=34) and those with hyperandrogenism caused by increased dihydrotestosterone (DHT) (n=66) were compared. In determining the type of hyperandrogenism and allocating patients to groups, DHT and total testosterone levels were determined by enhanced chemiluminescence. Subgroups of men with and without arterial hypertension were compared in the group of patients with hyperandrogenism due to an increase in total testosterone. Body mass index, waist circumference, systolic and diastolic blood pressure, pulse, and LH, SBHG, estradiol, blood multisteroid levels by isotope dilution liquid chromatography/tandem mass spectrometry, glucose, blood lipid spectrum, uric acid, creatinine, renin, potassium, sodium, and blood chloride were assessed in all patients. Patients with arterial hypertension additionally underwent daily BP monitoring, albuminuria assessment, electrocardiography, ocular fundus examination. The baseline threshold level of significance was p<0.05. For multiple comparisons, the p significance level was calculated using the Bonferroni correction.RESULTS. Statistically significant differences were found in the levels of 17-hydroxypregnenolone, 17-hydroxyprogesterone, and androstenedione, which were higher in men with elevated levels of total testosterone. No statistically significant differences in other laboratory parameters were found. No cases of increased blood pressure were detected in the group of men with elevated DHT. In the group of men with elevated total testosterone, 23,5% of men with arterial hypertension without targetorgan lesions were identified, while hyperandrogenism was associated with 17,6% of cases. Arterial hypertension associated with hyperandrogenism was characterized by a rise in blood pressure in the early morning hours. Estradiol levels, while remaining within normal limits, were statistically significantly lower in patients with arterial hypertension compared with men with elevated testosterone but without hypertension.CONCLUSION. No cases of arterial hypertension were observed in «physiological» hyperandrogenism due to elevated DHT levels, whereas its incidence in «physiological» hyperandrogenism due to elevated total testosterone was 23,5%. The features of steroidogenesis were increased production of 17-hydroxypregnenolone, 17-hydroxyprogesterone, and androstenedione in men with testosterone hyperandrogenism and decreased estradiol production in patients with arterial hypertension compared with patients without testosterone hyperandrogenism.
Efficacy of treatment with glucagon-like peptide receptor agonists-1 in Asian patients with type 2 diabetes mellitus
Authors: Khamnueva L. Yu. , Andreeva L. S. 
Published: May 2023

BACKGROUND. The projected 68% increase in patients with type 2 diabetes mellitus (T2D) in the upcoming decades and the specific pathophysiological course of the disease are critical factors for the development of optimal disease management tactics in the Asian population. It is now known that β-cell dysfunction is dominant in the pathogenesis of T2D in Asians. In a number of Asian countries, incretin therapy is the leading therapy.AIM. To review literature on glucagon-like peptide-1 (GLP-1) secretion and clinical trial results of GLP-1 receptor agonist class (GLP-1RA) drugs as well as to evaluate their effectiveness in Asian population with T2D.MATERIALS AND METHODS. A review of studies on pathophysiological aspects of GLP-1 secretion and evaluation of the efficacy of therapy with GLP-1RA preparations registered and used in clinical practice in Asian regions.RESULTS. Several studies in Asian countries have shown that intact GLP-1 levels were significantly lower in both T2D patients and healthy Japanese volunteers; as well as in patients with impaired glucose tolerance. It is suggested that either impaired secretion of GLP-1 in the gut, accelerated processing by dipeptidyl peptidase-4, or a combination of both are responsible for the decrease in GLP-1. The greater efficacy of GLP-1RA treatment in achieving glycemic control in Asian T2D patients was presented by Kim Y.G. et al. in a meta-analysis of 15 randomised controlled trials, the reduction in HbA1c on GLP-1RA treatment averaged -1.16% in Asian-dominated studies and -0.83% in non-Asian-dominated studies. In the PIONEER 9 clinical programme, similar results were obtained, with oral semaglutide having a more pronounced effect on glycaemic control in Japanese patients. Thus, the mean change in HbA 1c was -1.1%, 7 mg -1.5%, and 14 mg -1.7% at the 3 mg dose; whereas in the PIONEER 1 study in the global population, the mean change in HbA1c was -0.6%, -0.9% and -1.1% for 3, 7, 14 mg semaglutide, respectively. The PIONEER 10 study concluded that oral semaglutide was well tolerated by Japanese patients with T2D. Oral semaglutide reduced HbA1c (14 mg dose) and body weight (7 and 14 mg doses) more significantly compared to dulaglutide at 0.75 mg dose. Results of a pooled analysis of long-acting GLP-1RA showed a more significant reduction in cardiovascular event risk in the Asian subpopulation.CONCLUSION. The presented review describes benefits in glycemic control as well as in the reduction of relative cardiovascular event risks with GLP-1RA treatment in the Asian population, which requires further in-depth research and implies optimal management tactics in patients with T2DM.
Replicative and biochemical ageing features among females with primary ovarian insufficiency
Authors: Mikheev R. K. , Andreeva E. N. , Grigoryan O. R. , Sheremetyeva E. V. , Absatarova Yu. S. , Loginova E. V. 
Published: May 2023

BACKGROUND: One of the most dangerous reproductive pathologies is primary ovarian insufficiency (POI). Except manifestation in the age <40 years old it leads to demographical losses, decrease of chances for healthy aging. POI can be characterized as summary of secondary amenorrhea, total estrogenic deficiency and hypergonadotropic hypogonadism. Hence, POI has probably harmful effect on telomere length. Telomere length determining and sex steroid replacement therapy may be promising and effective to prevent decrease of life quality/ longevity among females with POI.AIM: To evaluate features of replicative (telomere length) and biochemical (metabolic syndrome) markers among females with primary ovarian insufficiency.MATERIALS AND METHODS. Research has been provided in collaboration between Endocrinology Research Centre of the Russian Ministry of Health and Lomonosov Moscow State University Medical Research and Educational Centre in the period since 10.01.2021 until 01.08.2022. Females with non-iatrogenic hypergonadotropic hypogonadism caused by primary ovarian insufficiency (n=33); healthy females of reproductive age (18–49 y.o.; n=24). Patients have undergone laboratory genetic (leucocyte telomere length), biochemical analyses. DNA extraction — with Qiagen DNA blood mini kit (Germany).Leukocyte telomere length — with real-time polymerase chain reaction PCR (Flow-fish). Soft program IBM SPSS Statistics (version 26,0 for Windows).RESULTS. Females with POI due to estrogenic deficiency have slightly shorter mean telomere length (10,0 [7,9–10,7] kB, than healthy females of reproductive age (10,8 [10,0–13,1] кБ, р<0,001). Females with POI due to estrogenic deficiency have higher chances for development of carbohydrate metabolism disturbances (prediabetes) (р<0,043), increasement of FSH level (р<0,001). FSH level correlates moderately and negatively (ρ=0,434) with leukocyte telomere length (р<0,001).CONCLUSIONS. Female with POI and receiving sex steroid replacement therapy have decrease of telomere length and increase of chances for carbohydrate metabolism disturbances in opposite to healthy reproductive females.
Experimental study on coal-fired flue gas HCl removal by injecting adsorbent into flue duct
Authors: Shen Zhen , Shen Ao , Yue Pujie , Liu Xiaoshuo , Ning Xiang , Li Haiyang , Meng Lei , Gu Xiaobing , Duan Yufeng 
Published: May 2023

Abstract
Adsorbent injection into flue ducts is an effective technology for controlling gaseous pollutant in coal-fired power plants. This study proposed a new technique of injecting dechlorinater into flue duct for HCl removal in order to realize the wet flue gas desulfurization (WFGD) wastewater sequestration and upgrade the gypsum quality, known as the source dechlorination method. Four alkaline-based adsorbents of CaO, Ca(OH)2 + 5 % NaOH, ethanol-modified CaO, and NaHCO3 were developed and investigated in a pilot scale 6 kW coal-fired circulating fluidized bed (CFB) combustion system for capturing flue gas HCl. The physical and chemical properties of the adsorbents were characterized to explore the reaction mechanisms affected by the adsorbent size and its distribution, active component loading, micro-structure, morphology, and crystal structure. The influences of the injection amount, resident time and flue gas temperature on the HCl removal efficiency were carried out, the dechlorination mechanism of the ethanol-modified CaO were discussed. The distribution of flue gas chlorine species across the air pollutant control devices (APCD) were obtained. This study provides basis for developing the technology of injecting dechlorinater into flue gas for HCl removal.
Anger: an underappreciated destructive force in healthcare
Authors: Grünebaum Amos , McLeod-Sordjan Renee , Pollet Susan , Moreno John , Bornstein Eran , Lewis Dawnette , Katz Adi , Warman Ashley , Dudenhausen Joachim , Chervenak Frank 
Published: May 2023

Abstract
Anger is an emotional state that occurs when unexpected things happen to or around oneself and is “an emotional state that varies in intensity from mild irritation to intense fury and rage.” It is defined as “a strong feeling of displeasure and usually of antagonism,” an emotion characterized by tension and hostility arising from frustration, real or imagined injury by another, or perceived injustice. It can manifest itself in behaviors designed to remove the object of the anger (e.g., determined action) or behaviors designed merely to express the emotion. For the Roman philosopher Seneca anger is not an uncontrollable, impulsive, or instinctive reaction. It is, rather, the cognitive assent that such initial reactions to the offending action or words are in fact unjustified. It is, rather, the cognitive assent that such initial reactions to the offending action or words are in fact unjustified. It seems that the year 2022 was a year when many Americans were plainly angry. “Why is everyone so angry?” the New York Times asked in the article “The Year We Lost It.” We believe that Seneca is correct in that anger is unacceptable. Anger is a negative emotion that must be controlled, and Seneca provides us with the tools to avoid and destroy anger. Health care professionals will be more effective, content, and happier if they learn more about Seneca’s writings about anger and implement his wisdom on anger from over 2000 years ago.
A skeptic’s guide to “intercultural communication”—debunking the “intercultural” and rethinking “culture”
Authors: Yu Hongbing 
Published: May 2023

AbstractStarting with a critique of so-called intercultural communication, the present paper contests and challenges the prevalent and dominant essentialist views of “culture”. It is exposed that these views have a detrimental underlying logic that is both destructive and self-destructive. Instead, the paper proposes a radically new idea of culture, a minimalist approach supported by insights gleaned from contemporary semiotic inquiry. In this approach, culture is defined as a biological instinct to acquire information through modeling, that is, learning by models. This instinct is at work, or is realized, in specific acts of such modeling, resulting in cultural practices and cultural artifacts. In the case of humanity, a cultural practice is anything a humandoesthat can be modeled by another human and a cultural artifact is anyobjectthat humans make andcanmodel. The paper argues it is imperative to keep in mind that when we deal with the “intercultural”, we are only dealing with concrete yet different cultural practices or cultural artifacts. This is an effective way to completely refute essentialism. In a sense, the paper is meant to be a wake-up call, instead of a fighting talk. Its main objective is not to negate or obliterate the field of “intercultural communication”, among others, but rather to save them from themselves—a true and worthy field of “intercultural communication” is a field against essentialism, instead of an accessory to essentialism, whether the commission is “before the fact” or “after the fact”.
Perception of regional and nonnative accents: a comparison of museum laboratory and online data collection
Authors: Bent Tessa , Lind-Combs Holly , Holt Rachael F. , Clopper Cynthia 
Published: May 2023

Abstract
Online testing for behavioral research has become an increasingly used tool. Although more researchers have been using online data collection methods, few studies have assessed the replicability of findings for speech intelligibility tasks. Here we assess intelligibility in quiet and two noise-added conditions for several different accents of English (Midland American, Standard Southern British, Scottish, German-accented, Mandarin-accented, Japanese-accented, and Hindi-English bilingual). Participants were tested in person at a museum-based laboratory and online. Results showed little to no difference between the two settings for the easier noise condition and in quiet, but large performance differences in the most difficult noise condition with an advantage for the participants tested online. Technology-based variables did not appear to drive the setting effect, but experimenter presence may have influenced response strategy for the in-person group and differences in demographics could have provided advantages for the online group. Additional research should continue to investigate how setting, demographic factors, experimenter presence, and motivational factors interact to determine performance in speech perception experiments.
Microscopic characteristics of copper wires with short-circuit molten marks in electrical fire
Authors: Xu Na , Ding Ning , Liu Long , Zaïri Fahmi , Guo Weimin , Li Fuwei , Li Nan , Tian Linan , Li Enxia , Chen Lizong 
Published: May 2023

Abstract
Electrical fire accidents occurred frequently all over the world in recent years, which had caused a large number of casualties and property losses. The main cause of electrical fire is electrical wire short circuit fault. Investigations of the characteristic and influence factors of the molten marks play an important role to determine the cause of fire. In the present work, microscopic characteristics of copper wires with short-circuit molten marks in electrical fire were investigated. Primary and secondary short-circuit molten marks (PMMs and SMMs) of copper wires were prepared by simulation test. The micro-morphology, microstructure and chemical composition of molten marks were observed and compared. Based on the quantitative characterization, effects of different overload currents and heating temperatures on the microstructure of molten marks were analyzed. The results would provide fundamental information for cause identification of the electrical fire.
Interlaminar shear modulus of cardboard obtained by torsional and flexural vibration tests
Authors: Yoshihara Hiroshi , Yoshinobu Masahiro , Maruta Makoto 
Published: May 2023

Abstract
The interlaminar shear modulus of cardboards was measured using torsional vibration (TV) and flexural vibration (FV) methods. In the TV method, the sample widths were decreased during the tests, and the interlaminar and in-plane shear moduli were determined using the data obtained based on the different widths. By contrast, in the FV method, the resonance frequencies from the first to third FV modes were measured using samples of various lengths, and the interlaminar shear modulus and Young’s modulus in the length direction were calculated using Timoshenko’s vibration theory. In addition to the experiment, modal analyses based on the finite element (FE) method were performed, and the sample configurations used to accurately obtain the interlaminar shear modulus were experimentally and numerically investigated. The TV method did not allow the interlaminar shear modulus to be obtained appropriately because the vibration behavior often deviated from that theoretically derived by the TV equation. By contrast, the FV method allowed the interlaminar shear modulus to be obtained appropriately for a wide range of sample lengths.
Barriers in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) management: perspectives from health practitioners
Authors: Li Arthur Sone-Wai , Wong Aquina Lim Yim , Matthewson Mandy , Van Niekerk Leesa , Garry Michael 
Published: May 2023

Abstract

Objectives
Chronic prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a complex condition which causes a significant burden on the diagnosed individuals. Assessment and management are perplexing, often resulting in unsatisfactory outcomes. Existing research has only focused on patients’ perspectives of pain experiences, but scant evidence is available to understand the barriers that undermine effective pain management. Using an exploratory approach, this study examined these barriers from practitioners’ perspectives.

Methods
Twelve semi-structured interviews were conducted with practitioners across disciplines who have experience in chronic pelvic pain management in males. Practitioners expressed their views and experiences in supporting men with CP/CPPS and what barriers they perceived when providing treatment for patients. Data were analysed using reflexive thematic analysis supported by NVivo software.

Results
Five broad and interrelated themes were identified: (1) Where to Start, (2) Insufficient Resources, (3) Prioritisation, (4) Training and Confident Practice and (5) Constraints in Help-Seeking.

Conclusions
Practitioners value multimodal management using a biopsychosocial approach; however, practical challenges prevent practitioners from choosing and applying this approach in clinical practice. The findings also identified some unique challenges faced by men with CP/CPPS consistent with previous evidence from patient perspective. Refining terminology, developing specific resources, and increasing psychosocial treatment options are urgently needed.
Image quality improvement through turbid media by using graphene nanoplates
Authors: Carrilero Laura , Castro José Ramón , Pérez Sandra , Belenguer Tomás , Salazar Félix 
Published: May 2023

Abstract
Imaging through turbid media leads to a great loss of information decreasing the image quality. This loss of quality is due to the light interaction with the medium, since part of the light will pass through it, but another part will be scattered generating a blurred image pattern. In this work we try to decrease this problem by adding an absorbent, eliminating part of the scattered radiation responsible for the turbidity. With this aim, we use graphene nanoplates as an absorbent and we also compare the experimental results with black carbon powder.
Die Idee der Jerusalemer Tempelbibliothek
Authors: Oepping Florian 
Published: May 2023

Zusammenfassung
Der Artikel analysiert 2 Könige 22,3–11 sowohl synchron als auch diachron. Beide Analysen widerlegen die Existenz einer Tempelbibliothek in vorexilischer Zeit. Mit dem Wegfall einer solchen Bibliothek wird ebenfalls die Frage nach dem Bildungsstand der Priester aufgeworfen. Der Artikel beschreibt den Jerusalemer Tempel als Ort des Kultes; Priester waren primär für die Opfer verantwortlich. Diese Charakterisierung lässt weitere Rückschlüsse und Überlegungen in Bezug auf Religion und Theologie der vorexilischen Zeit zu.
King Zedekiah’s Release of Slaves for the Strategic Harmony of a Besieged Jerusalem (Jer 34)
Authors: Scolnic Benjamin E. 
Published: May 2023

Abstract
King Zedekiah of Judah’s covenant to release Hebrew slaves during the siege of Jerusalem by the Babylonians in 588/587 and Jeremiah’s idealistic denunciation of the reclaiming of those slaves in Jer 34 has been the subject of interesting scholarly debate. For all the proposed foreign and intra-Biblical parallels, the policy was purely pragmatic and can be understood as a recognizable strategy from ancient texts that recommend procedures during a siege. Therefore when the siege is temporarily lifted, the policy is reversed.
The controlled fission, fusion and collision behavior of two species Bose–Einstein condensates with an optical potential
Authors: He Zhang-Ming , Zhu Qian-Quan , Zhou Xin 
Published: May 2023

Abstract
By using the Crank–Nicolson method, we investigate numerically the dynamical properties of bright–bright solitons in two species Bose–Einstein condensates (BECs) trapped in an optical lattice. We confirm that the soliton splitting behavior occurs at a critical depth of optical potential. The splitting behavior of solitons and the fusion behavior of condensates can be accurately controlled by adjusting the depth and lattice parameter of optical potential, the initial amplitude and position of solitons, and the interspecies interactions. When the lattice parameter is fixed but the interspecies interaction increased exponentially with the time, each soliton splits into two soltions with different amplitude, and partial fusion of two species BECs can be found. While the interspecies interaction remains unchanged but the lattice parameter increases exponentially with the time, interestingly, the bright solitons with zero initial velocity can pass through each other and accomplish a transmission collision. Furthermore, for the case of both the interspecies interaction and lattice parameter increased exponentially with the time, a head-on collision of the bright solitons in two species BECs occurred. After the collision, each soliton splits into two soltions with equal amplitude. Meanwhile, the complete fusion of two species BECs can be observed. The relevant results can provide help for the precise manipulation of BECs experiments.