bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin infectome of patients with a tick bite history
Authors: Zhang Jie , Zheng Yuan-Chun , Chu Yan-Li , Cui Xiao-Ming , Wei Ran , Bian Cai , Liu Hong-Bo , Yao Nan-Nan , Jiang Rui-Ruo , Huo Qiu-Bo , Yuan Ting-Ting , Li Jie , Zhao Lin , Li Lian-Feng , Wang Qian , Wei Wei , Zhu Jin-Guo , Chen Mei-Chao , Gao Yan , Wang Fei , Ye Jin-Ling , Song Ju-Liang , Jiang Jia-Fu , Lam Tommy Tsan-Yuk , Ni Xue-Bing , Jia Na 
Published: February 2023

IntroductionTicks are the most important obligate blood-feeding vectors of human pathogens. With the advance of high-throughput sequencing, more and more bacterial community and virome in tick has been reported, which seems to pose a great threat to people.MethodsA total of 14 skin specimens collected from tick-bite patients with mild to severe symptoms were analyzed through meta-transcriptomic sequencings.ResultsFour bacteria genera were both detected in the skins and ticks, including Pseudomonas, Acinetobacter, Corynebacterium and Propionibacterium, and three tick-associated viruses, Jingmen tick virus (JMTV), Bole tick virus 4 (BLTV4) and Deer tick mononegavirales-like virus (DTMV) were identified in the skin samples. Except of known pathogens such as pathogenic rickettsia, Coxiella burnetii and JMTV, we suggest Roseomonas cervicalis and BLTV4 as potential new agents amplified in the skins and then disseminated into the blood. As early as 1 day after a tick-bite, these pathogens can transmit to skins and at most four ones can co-infect in skins.DiscussionAdvances in sequencing technologies have revealed that the diversity of tick microbiome and virome goes far beyond our previous understanding. This report not only identifies three new potential pathogens in humans but also shows that the skin barrier is vital in preventing horizontal transmissions of tick-associated bacteria or virus communities to the host. It is the first research on patients’ skin infectome after a tick bite and demonstrates that more attention should be paid to the cutaneous response to prevent tick-borne illness.
Periodontal disease is associated with the risk of cardiovascular disease independent of sex: A meta-analysis
Authors: Leng Yurong , Hu Qinwen , Ling Qin , Yao Xiongda , Liu Menglu , Chen Jiawei , Yan Zhiwei , Dai Qun 
Published: February 2023

ObjectivesStudies have established a link between periodontal disease and cardiovascular disease (CVD), but it is unclear whether there is a sex difference in their association.MethodsThe PubMed, Embase, and Cochrane databases were searched until June, 21 2022. Cardiovascular outcomes included any CVD, myocardial infarction (MI), coronary heart disease (CHD), or stroke. Studies reported the prevalence of CVD in patients with periodontal disease and the relationship between periodontal disease and CVD. The study is registered with PROSPERO (CRD42022333663). The level of evidence and recommendations is assessed by the Grading of Recommendations for Assessment, Development and Evaluation (GRADE).ResultsTwenty-six studies were included. In patients with periodontal disease, the prevalence of CVD was 7.2% [9 studies; 95% confidence interval (CI): 2.7–13.6%], and prevalence for CHD, hypertension, stroke, and heart failure was 6.6, 25.3, 1, and 1.1%, respectively. There was a significant association between periodontal disease and CVD in men [odds ratio (OR) = 1.22; 95% CI: 1.12–1.34] and women (OR = 1.11; 95% CI: 1.05–1.17), with no significant sex difference (P &gt; 0.05).ConclusionCardiovascular disease is relatively common in patients with periodontal disease, and an increased risk of CVD is associated with periodontal disease independent of sex. Interventions targeting periodontal disease may be beneficial for CVD.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022333663.
Eugenol modulates the NOD1-NF-κB signaling pathway via targeting NF-κB protein in triple-negative breast cancer cells
Authors: Shi Xiaoyu , Zhang Weiwei , Bao Xiao , Liu Xiaozhu , Yang Ming , Yin Chengliang 
Published: February 2023

BackgroundThe most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC), has a worse prognosis and a higher probability of relapse since there is a narrow range of treatment options. Identifying and testing potential therapeutic targets for the treatment of TNBC is of high priority.MethodsUsing a transcriptional signature of triple-negative breast cancer collected from Gene Expression Omnibus (GEO), CMap was utilized to reposition compounds for the treatment of TNBC. CCK8 and colony formation experiments were performed to detect the effect of the candidate drug on the proliferation of TNBC cells. Meanwhile, transwell and wound healing assay were implemented to detect cell metastasis change caused by the candidate drug. Moreover, the proteomic approach was presently ongoing to evaluate the underlying mechanism of the candidate drug in TNBC. Furthermore, drug affinity responsive target stability (DARTS) coupled with LC-MS/MS was carried out to explore the potential drug target candidate in TNBC cells.ResultsWe found that the most widely used medication, eugenol, reduced the growth and metastasis of TNBC cells. According to the underlying mechanism revealed by proteomics, eugenol could inhibit TNBC cell proliferation and metastasis via the NOD1-NF-κB signaling pathway. DARTS experiment further revealed that eugenol may bind to NF-κB in TNBC cells.ConcludesOur findings pointed out that eugenol was a potential candidate drug for the treatment of TNBC.
Acanthopagrus latus migration patterns and habitat use in Wanshan Islands, Pearl River Estuary, determined using otolith microchemical analysis
Authors: Tang Guanglong , He Zehua , Liu Yong , Xiao Yayuan , Bi Sheng , Sun Ye , Liang Jiman , Wu Peng , Wang Teng , Ye Jinyu , Li Chunhou 
Published: February 2023

IntroductionThe waters surrounding the Wanshan Islands are important traditional fishing grounds in China, with rich habitat types. Acanthopagrus latus is an economically important species in this area; however, the distribution of its spawning grounds and habitat use patterns remain unknown.MethodsThus 100 otolith samples of A. latus were collected from three geographic areas (MW: Qi’ao Island Mangrove Water Habitat; OW: Yamen Estuary Oyster Farm Water Habitat; RW: Dong’ao-Guishan Island Reef Water Habitat), and the concentrations of Sr and Ca along the shortest axis of the vertical otolith annual or lunar rings were measured to span the entire life cycle of A. latus, with the core and edge areas corresponding to environmental characteristics at birth and capture, respectively.Results and discussionAnalysis of covariance (ANCOVA) revealed that the ratios of Sr/Ca in otolith edges of RW samples are significantly higher than those of OW and MW samples; however, both the values of Sr/Ca ratio in otolith cores collected from OW and MW are comparable with those of RW samples. Cluster analysis and non-metric multidimensional scaling (nMDS) indicated that at the juvenile stage, RW and MW individuals in the two main clusters belonged to the same cluster. There was no significant difference between the cores of the RW samples and the edges of the MW and OW samples. Therefore, the spawning area of A. latus in the Wanshan Islands is thought to have originated from low to medium-salinity waters with mangroves and oyster farm habitats in the Pearl River Estuary. A. latus from RW was found to have three distinct habitat-use patterns: 1) Marine Resident (7.2% of sampled fish) fish that remain in marine habitats for life; 2) Marine Migrant (16.4% of sampled fish) juveniles inhabit low to moderate salinity habitats and migrate to marine habitats as they grow; 3) Estuarine Visitor (76.4% of sampled fish) repeated migration between low to moderate salinity and marine habitats. This suggests widespread migration between estuarine and marine habitats throughout the ontogeny. The plasticity of this habitat use and the protection of spawning grounds should be considered in future fisheries management because A. Latus in this area has been the victim of the overexploitation of resources.
Association between dietary inflammatory index and risk of endometriosis: A population-based analysis
Authors: Liu Penglin , Maharjan Rashmi , Wang Yixiao , Zhang Yubo , Zhang Yanqin , Xu Chunyu , Geng Yuning , Miao Jinwei 
Published: February 2023

Background and aimsChronic inflammation plays a significant role in the etiology of endometriosis, which might be affected by dietary intake. This study aimed to investigate the association between dietary inflammatory index (DII) and the risk of endometriosis.MethodsA cross-sectional analysis using data from the National Health and Nutrition Examination Survey (1999–2006) was conducted on 3,410 American participants, among whom 265 reported a diagnosis of endometriosis. DII scores were calculated based on the dietary questionnaire. The association of DII scores with endometriosis was evaluated by adjusted multivariate logistic regression analyzes, which were further investigated in the subgroups.ResultsIn the fully adjusted models, the odds ratio (OR) for endometriosis participants in the highest and middle tertiles of DII scores were 1.57 [95% confidence interval (CI): 1.14–2.17] and 1.18 (95% CI: 0.84–1.65), compared to the lowest tertile (Ptrend = 0.007). In subgroup analyzes, the significant positive association between DII scores and the endometriosis risk was also observed in non-obese women (ORtertile3vs1: 1.69, 95% CI: 1.12–2.55; Ptrend = 0.012), women without diabetes (ORtertile3vs1: 1.62, 95% CI: 1.16–2.27; Ptrend = 0.005), women with hypertension (ORtertile3vs1: 2.25, 95% CI: 1.31–3.87; Ptrend = 0.003), parous women (ORtertile3vs1: 1.55, 95% CI: 1.11–2.17; Ptrend = 0.011), and women using oral contraceptives (ORtertile3vs1: 1.63, 95% CI: 1.15–2.30; Ptrend = 0.006).ConclusionThis nationally representative study found that increased intake of the pro-inflammatory diet, as a higher DII score, was positively associated with endometriosis risk among American adults. Our results suggested anti-inflammatory dietary interventions may be promising in the prevention of endometriosis. Further prospective studies are necessary to confirm these findings.
Prognostic risk factors and nomogram construction for sebaceous carcinoma: A population-based analysis
Authors: Xu Wen , Le Yijun , Zhang Jianzhong 
Published: February 2023

BackgroundSebaceous gland carcinoma (SGC) is a rare tumor for which there are currently no effective tools to predict patient outcomes. We analyzed the clinical and pathological prognostic risk factors of sebaceous carcinoma based on population data and created a nomogram of related risk factors, which can more accurately predict the 3-, 5-, and 10-year overall survival (OS) rates of patients.MethodsSGC patients between 2004 and 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database and randomly assigned to training and validation cohorts. Relevant risk factors were identified by univariate and multivariate COX hazards regression methods and combined to produce a correlation nomogram. The concordance index (C-index), the area under the receiver operating characteristic (AUC) curve, and calibration plots have demonstrated the predictive power of the nomogram. Decision curve analysis (DCA) was used to measure nomograms in clinical practice.ResultsA total of 2844 eligible patients were randomly assigned to 70% of the training group (n=1990) and 30% of the validation group (n=854) in this study. The derived meaningful prognostic factors were applied to the establishment of the nomogram. The C-index for OS was 0.725 (95% CI: 0.706-0.741) in the training cohort and 0.710 (95% CI: 0.683-0.737) in the validation cohort. The AUC and calibration plots of 3-, 5-, and 10-year OS rates showed that the nomogram had good predictive power. DCA demonstrated that the nomogram constructed in this study could provide a clinical net benefit.ConclusionWe created a novel nomogram of prognostic factors for SGC, which more accurately and comprehensively predicted 3-, 5-, and 10-year OS in SGC patients. This can help clinicians identify high-risk patients as early as possible, carry out personalized treatment, follow-up, and monitoring, and improve the survival rate of SGC patients.
New insights into the behavioral structure of Pikler educators: An application of T-pattern detection and analysis with THEME
Authors: Belza Haizea , Portell Mariona , Herrán Elena , Anguera M. Teresa 
Published: February 2023

IntroductionThe recent generalization of early childhood schooling has given rise to a need for the development of rigorous, specific training programs aimed at early education professionals (0–3 years of age). This work emanates from the unique nature of Pikler-Lóczy education as a reference for early childhood education centers, and its expertise in providing quality care in an everyday classroom situation. The aim of the study is to use T-pattern detection and analysis, within the framework of observational methodology, to identify relevant aspects of the choreography followed by Pikler educators during breakfast, and thus provide substantial material with a view to creating a training plan.MethodsTwo expert educators in Pikler-Lóczy education were directly and systematically observed in their own classrooms, following a nomothetic, follow-up and multidimensional design. The observation instrument underwent a molarization process so that the detected elements would be more significant and understandable for novice educators.ResultsUsing THEME, the invariant aspects of the educators’ behavior were analyzed. The significance level for the critical interval was the THEME default (α = 0.005). The results show: on the one hand, changes expected in T-patterns in accordance with the observation instrument molarity; and on the other hand, stability in terms of the comparison between the two educators.DiscussionThese results help us to identify the complex structure of the breakfast choreography, and how educators establish interaction with children. In addition to specific issues pertaining to Pikler-Lóczy education, the conclusions highlight the advantages of using T-pattern analysis within the framework of observational methodology, in order to dissect a mealtime routine in its natural context, and explain components of early childhood education intervention that satisfy basic childhood needs. This constitutes a starting point from which to generate instructive material for the training of professionals working in early education.
A seven-year longitudinal study of the association between neurocognitive function and basic self-disorders in schizophrenia
Authors: Haug Elisabeth , Øie Merete G. , Svendsen Ingrid H. , Møller Paul , Nelson Barnaby , Melle Ingrid 
Published: February 2023

IntroductionBasic self-disorders (SDs) and neurocognitive impairments are fundamental trait-like aspects of schizophrenia spectrum disorders. There has been little research on the association between SDs and neurocognitive impairments in schizophrenia, and no longitudinal studies have investigated if they are related. The aim of this study was to investigate the association between SDs and neurocognitive function in a follow-up study of patients with schizophrenia.MethodsSDs and neurocognition were examined in 35 patients with schizophrenia during their first treatment and 7 years later (mean 7.1, SD 0.42). SDs were examined with the Examination of Anomalous Self-Experience (EASE) instrument. The neurocognitive examination included assessments of psychomotor speed, executive- and memory functions.ResultsPoorer executive functions at baseline were significantly associated with more SDs 7 years later and smaller reductions in SDs over time. There were no significant associations between other neurocognitive functions and SDs.DiscussionExecutive functions are important for self-regulation, and impairments in these functions in everyday life may have an impact on the development and/or persistence of SDs.
Ocular blood flow evaluation by laser speckle flowgraphy in pediatric patients with anisometropia
Authors: Itokawa Takashi , Matsumoto Tadashi , Matsumura Saiko , Kawakami Momoko , Hori Yuichi 
Published: February 2023

PurposeTo determine the differences and reproducibility of blood flow among hyperopic anisometropic, fellow, and control eyes.MethodsWe retrospectively studied 38 eyes of 19 patients with hyperopic anisometropia (8.2 ± 3.0 years of age) and 13 eyes of eight control patients (6.8 ± 1.9 years). We measured the optic nerve head (ONH) and choroidal circulation using laser speckle flowgraphy (LSFG) and analyzed the choroidal mean blur rate (MBR-choroid), MBR-A (mean of all values in ONH), MBR-V (vessel mean), MBR-T (tissue mean), and sample size (sample), which are thought to reflect the ONH area ratio, area ratio of the blood stream (ARBS). We then assessed the coefficient of variation (COV) and intraclass correlation coefficient (ICC) and compared the differences among amblyopic, fellow, and control eyes in MBR, sample, and ARBS.ResultsThe ONH, MBR-A, MBR-T, and ARBS of amblyopic eyes were significantly higher than those of fellow eyes (P &lt; 0.01, P &lt; 0.05, and P &lt; 0.05, respectively), and control eyes (MBR-A and ARBS, P &lt; 0.05, for both comparisons). The sample-T (size of tissue component) in amblyopic eyes was significantly smaller than that in fellow and control eyes (P &lt; 0.05). Blood flow in the choroid did not differ significantly between the eyes. The COVs of the MBR, sample, and ARBS were all ≤10%. All ICCs were ≥0.7. The COVs of pulse waveform parameter fluctuation, blowout score (BOS), blowout time (BOT), and resistivity index (RI) in the ONH and choroid were ≤10%.ConclusionThe MBR value of the LSFG in children exhibited reproducibility. Thus, this method can be used in clinical studies. The MBR values of the ONH in amblyopic eyes were significantly high. It has been suggested that measuring ONH blood flow using LSFG could detect the anisometropic amblyopic eyes.
Psychosocial outcomes and peer influences among multiracial adolescents in the United States
Authors: Grilo Stephanie A. , Santelli John S. , Nathanson Constance , Catallozzi Marina , Abraido-Lanza Ana F. , Adelman Sarah , Hernández Diana 
Published: February 2023

ObjectiveTo examine racial and ethnic self-identification among adolescents and explore psychosocial outcomes and peer treatment for multiracial adolescents in the United States.MethodsData are from the 2014 Child Development Supplement, a subsample of the Panel Study of Income Dynamics. Data were weighted to be nationally representative. Descriptive statistics were used to describe the population and to explore family and parent demographics. Multivariable regressions tested for differences in psychosocial outcomes and peer treatment and group behaviors for multiracial youth in comparison to their single race peers.ResultsBlack multiracial youth had significantly lower scores on the children's depression index compared to single race Black youth, and White multiracial youth reported significantly higher rates of peer mistreatment in comparison to White single race youth. Black multiracial and White multiracial adolescents reported similar positive and negative peer group behaviors.ConclusionsComplex patterns emerge when examining the psychosocial and peer treatment variables presented in this analysis for multiracial adolescents and their single-race peers. The findings regarding depressive symptoms and peer bullying point to signs of different relationships between multiracial groups. White multiracial adolescents report worse outcomes than their White single-race peers, but Black multiracial adolescents reporting better outcomes than their Black single-race peers.
How long can Chinese women work after retirement based on health level: Evidence from the CHARLS
Authors: Cheng Xiya , Fang Ya , Zeng Yanbing 
Published: February 2023

ObjectiveTo further enhance the understanding of factors impacting female participation in the workforce based on health levels and to measure the excess work capacity of middle-aged and older female groups by residence and educational level.MethodsData of women aged 45–74 were accessed from the China Health and Retirement Longitudinal Study (CHARLS) from 2011, 2013, 2015, to 2018. The health status of women was comprehensively evaluated by single health variables and frailty index. A Probit model was used to measure the excess working capacity of women by region (rural/urban) and educational level, taking all women aged 45–49, rural women aged 45–49, and rural (illiterate) women in all age groups as the benchmark, respectively.ResultsThe excess capacity of all Chinese women aged 50–64 is 1.9 years, and that of women aged 50–74 is 5.1 years. The excess work capacity of women in urban and rural areas and with different educational levels is heterogeneous. The excess working capacity of urban women aged 50–64 is 6.1–7.8 years, and that of urban women aged 50–74 is 9.8–14.9 years. The excess working capacity of urban women aged 50–64 is about 6 times that of rural women. The excess work capacity of highly educated women was 3 times higher than that of illiterate women.ConclusionThe potential work capacity of Chinese women remains to be exploited, especially for urban and highly educated middle-aged and older women with better conditions of health, whose potential is more significant. A rational retirement policy for women and the progressive implementation of an equal retirement age for men and women will contribute to further advancement of gender equality and healthy aging in the workplace in China.
A comparative study of stress experienced by Swedish and Norwegian police officers
Authors: Padyab Mojgan , Hansson Jonas , Sundqvist Johanna , Inzunza Miguel , Ghazinour Mehdi 
Published: February 2023

IntroductionPolice officers work in a variable environment under different circumstances and often involves stressful situations. This include working irregular hours, ongoing exposure to critical incidents, confrontations and violence. community police officers are mainly out in the society and have daily contact with the general public. critical incidents can also consist of being criticized and stigmatized as a police officer, both from the public but also lack of support from their own organization. There is evidence on negative impacts of stress on police officers. However, knowledge about the nature of police stress and its various types is insufficient. It is assumed that there are common stress factors which are universal among all police officers in different contexts but there is a lack of comparative studies to provide empirical evidence. The aim of this study is to compare different types of stress among police officers in Norway and Sweden and how the pattern of experiencing stress has changed over time in these countries.MethodsThe study population consisted of patrolling police officers from 20 local police districts or units in all seven regions in Sweden (n = 953) and patrolling police officers from four police districts in Norway (n = 678). A 42-item Police Stress Identification Questionnaire was used to measure the stress level.ResultsThe findings show differences in types of stressful events as well as its severity among police officers in Sweden and Norway. The level of stress decreased over time among Swedish police officers whereas it showed no change or even an increase among the Norwegian participants.DiscussionThe results of this study are relevant for policy-makers, police authorities and lay police officers in each country to tailor their efforts to prevent stress among police officers.