bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation of Cefdinir Ternary Solid Dispersion and Stability Study under Harsh Conditions
Authors: Naamaa A. Naama  , Ghaidaa S. Hameed  , Dalya Basil Hanna  , Zainab H. Mahdi  
Published: January 2025

Cefdinir (CEF) is classified as a third-generation cephalosporin within class IV of the Biopharmaceutical Classification System (BCS). Cefdinir has low solubility and permeability, which may reduce oral bioavailability.

The aim of this research was the preparation of cefdinir ternary solid dispersion in order to enhance its solubility. Then, after evaluating this ternary SD, investigate its stability under harsh conditions. In addition, formulation and evaluation of CEF ternary SD as capsule dosage form. The ternary SD is prepared by the solvent evaporation method using CEF, curcumin, and polyvinylpyrrolidone k30 in a weight ratio of 1:1:1. The ternary SD is subject to evaluation using Differential Scanning Calorimetry (DSC), Powder X-ray Diffractometry (PXRD), and Fourier Transform Infrared Spectroscopy (FTIR), saturated solubility, release, antibacterial activity, and a two months stability study under conditions of 40 ºC and 75% relative humidity. Then, six different capsule formulas were prepared using different excipients; each formula contained 300 mg of CEF. The capsule formulas were subjected to pre-formulation and capsule evaluation tests, which included weight variation, drug content, disintegration time, and In-vitro dissolution tests. The selected optimum capsule formula was subjected to further antibacterial activity test. Evaluation of ternary SD showed that, the system is totally amorphous with enhanced dissolution, saturated solubility, and antibacterial activity compared to pure CEF. Stability studies showed that, ternary SD remains amorphous after two months. Compared to commercial capsules (Sefarin® 300 mg) and other formulas, the F6 formula released 90% of CEF in 30 min. Antibacterial activity test results showed that the F6 formula was active against Staphylococcus aureus and Proteus vulgaris bacterial isolate. This research concludes that CEF solubility, antibacterial activity enhancement, and stability insurance could be obtained by preparing CEF ternary SD. All the ternary SD prepared capsule formulas showed enhancements in release compared to commercial capsules.
Reflections of ChatGPT on Gender Discourse: A Qualitative Analysis of Generated Stories
Authors: Sarıkaya Tugay , Yılmaz Elif 
Published: January 2025

This study aims to analyze how ChatGPT addresses gender discourse within the family context. The primary research question guiding this analysis is: "How are gender discourses reflected in ChatGPT?" To investigate this question, 10 stories that illustrate family relationships were generated by ChatGPT, each limited to 150 words and written in English. The collected data were examined using Van Dijk's critical discourse analysis method, allowing for a detailed analysis of each story individually before identifying common themes.

Artificial intelligence and algorithms are crucial for this research, underscoring the impact of such advancements on social dynamics. The perspective and attitude of these scientific developments towards social issues are particularly noteworthy, especially regarding how artificial intelligence addresses gender discourses in both traditional and digital media. ChatGPT's rapid development in this area is of particular importance. This article provides an overview of Artificial Intelligence, ChatGPT, Gender, and Language, with a focus on ChatGPT's reflections on gender discourse. The findings indicate that gender-based power relations are prominent in the narratives generated by ChatGPT, revealing elements associated with dominant ideologies.
Bangladeshi Female Graduate Doctors Leaving Medical Profession: A Real Threat to Health System or a Rumor
Authors: Akhter Najnin , Kabir Talukder Md Humayun 
Published: January 2025

Background: Female graduate doctors represent a major part of health care/ educational services in Bangladesh. But a portion of female graduate doctors leaving their profession immediately or after sometimes of completion of their graduation, even some of them never registered themselves under Bangladesh Medical & Dental Council (BM&DC). Objective: This research aimed to find out percentages of female graduate doctors leaving medical profession and different reasons behind it. Methods: This cross sectional descriptive research was carried out in the Centre for Medical Education (CME), Mohakhali, Dhaka from July 2022 to June 2023. Data were collected through one self-administered semi-structured questionnaire among 500 female graduate doctors who got their registration from 2005-2020 and selected by convenient and snowball sampling. Results: Among 500 female graduate doctors, 428 (85.6%) were involved in different health care services and rest 72 (14.4%) were not involved and among rest 14.4%, about 10% never involved in health care services after completion of their graduation. When 72 respondents female graduate doctors who were not involved asked about their current professions, about one fourth (25%) mentioned they were doing ‘online businesses’, 15.02% were ‘purely housewife’ and 12.5% were ‘changing profession to others’. Among 72 respondents female graduate doctors, one third (33.33%) chose other profession for 'better income'. The most two common reasons for not involving were 'to care children' (39.7%) and 'absence of day care centers' (20.5%). Nearly half (45.5%) of the respondents chose 'establishment of day care / breast feeding centers' when they asked what strategies the government should take to utilize female work force effectively. Conclusions: Female graduate doctors who were not involved in health system mentioned different reasons behind their decisions and strategies require to be taken by the Government to overcome such conditions.
BJME, Volume-16, Issue-01, January 2025: 15-25
Peran Orang Tua dalam Pembentukan Karakter Anak di Era Digital
Authors: Hatiah Hatiah , Muslimah Muslimah 
Published: January 2025

The aim of this research is to describe the role of parents in forming children's character in the digital era. In this research, researchers used descriptive qualitative methods with the type of library research. The data in this research was collected through document search techniques such as books, articles and so on related to the research theme. Data analysis is carried out in several stages, namely data categorization or condensation, then the data is described, the final stage is drawing conclusions. The research results show that the role of parents in shaping children's character is very large. As a parent, protecting your child and providing positive encouragement is also something you should do. Minimizing the negative impact of digital technology is the task of parents. There are several things you can do to deal with it. Broadly speaking, there are three duties of parents, namely to educate (advice), limit and fortify.
Keywords: Forming Children's Character, Digital Era, Role of Parents
SOSIALISASI PELESTARIAN DAN TOPOGRAFI BAHASA TOLAKI DI DESA PUASANA KECAMATAN MORAMO UTARA KABUPATEN KONAWE SELATAN
Authors: Ino La , Janu La , Samsul Samsul , Nirmalasari Nirmalasari , Saerudin Sahur , Nurjannah Nurjannah 
Published: January 2025

Jumlah bahasa daerah yang ada di Indonesia dari tahun ke tahun terus mengalami kemerosotan. Puluhan bahasa daerah terancam punah karena tidak ada lagi penutur yang memakai bahasa tersebut. Kemajuan informasi dan gempuran bahasa asing menjadi salah satu penyebab bahasa daerah tidak lagi mampu bertahan. Pelestarian bahasa dengan cara mempertahankan bahasa daerah atau bahasa ibu (mother tongue) perlu disosialisasikan kepada masyarakat khususnya generasi muda sebagai generasi penerus. Kegiatan ini merupakan salah satu solusi yang dapat dilakukan untuk mendorong masyarakat agar lebih peduli terhadap bahasa daerah. Selain itu kegiatan ini dapat memotivasi domain keluarga sebagai basis utama pemertahanan bahasa daerah untuk mewariskan bahasa ke generasi berikutnya. Bahasa-bahasa daerah yang ada di Indonesia memiliki ciri dan karakteristik yang berbeda antara satu bahasa dengan bahasa yang lain. Keunikan bahasa setiap daerah menandakan identitas daerah tertentu, sehingga penting untuk dilakukan suatu kajian yang dapat dengan jelas menunjukkan keunikan tersebut. Hal itu perlu menjadi perhatian utama, karena kebanyakan dalam menyebut bahasa yang satu dengan yang lain merupakan bahasa yang berbeda atau hanya perbedaan variasi, belumlah jelas. Masing-masing daerah tidak ingin bahasanya disama-samakan dengan bahasa di daerah yang lain (S, Susiati, 2019). Kekayaan luar biasa yang tanpa kita sadari perlahan lenyap dan punah di negeri ini. Yaitu bahasa daerah. Bahasa daerah adalah kekayaan terakhir sebuah bangsa sebagai bukti adanya peradaban, seni dan budaya bahkan eksistensi bangsa itu sendiri yang diwariskan baik secara lisan maupun tulisan. Kondisi terancamnya bahasa daerah mendorong Badan Unesco PBB menetapkan tanggal 21 Februari sebagai hari bahasa daerah internasional. Menurut data Organisasi Pendidikan, Keilmuan dan Kebudayaan PBB (Unesco: United Nations Education, Social and Culture Organization) pada 2014 menyebutkan bahwa sebanyak 3000 dari 6000 bahasa di dunia hampir punah, sebagian besar milik etnis minoritas (Republika, 24/9/14). Menurut Direktur Unesco Sheldon Shaefffer bahwa 96 persen dari bahasa yang hampir punah (3000 bahasa) itu hanya digunakan oleh 4 persen populasi dunia. Lebih parahnya menurut data dari Ethnologue Languages of the World melaporkan bahwa untuk kawasan Asia Tenggara terdapat 527 bahasa terancam hampir punah. Sedangkan di Indonesia menurut hasil penelitian Lembaga Ilmu Pengetahuan Indonesia (LIPI) bahwa dari 746 bahasa daerah yang ada di tanah air sebanyak 169 bahasa terancam punah dengan kondisi jumlah penutur di bawah 500 orang, sudah tua-tua serta tidak ada generasi muda pengganti dan berada di lokasi terpencil.
Kata Kunci: Bahasa daerah, pelestarian, Kecamatan Moramo Utara, KKN tematik .
Worksop Kebertahanan Kosakata Bahasa Konjo Dalam Bidang Pertambakan di Desa Tobimeita Kecamatan Motui Kabuapaten Konawe Utara
Authors: La Sudu  , Maliudin  , Lestari Wati  , Irma Magara  , Nurmin  
Published: January 2025

Desa Tobimeita masuk wilayah lingkar tambang OSS dan VDNI sehingga keberadaan tambang tersebut sangat mempengaruhi penghasilan tambak mereka. Saat ini tambak mereka sebagian sudah tercemar limbah perusahaan. Masyarakat setempat sudah mulai meninggalkan kebiasaan bertambak dan beralih menjadi pekerja karyawan tambang. Hilangnya mata pencaharian mereka akan berdampak pada penggunaan kosakata bahasa Konjo pada lingkungan pertambakan. Mengantisipasi hal tersebut, maka pengabdian tentang “Workshop Kebertahanan Kosakata Bahasa Konjo dalam Bidang Pertambakan di Desa Tobimeita Kabupaten Konawe Utara” dianggap penting untuk dilakukan. Pengabdian ini bertujuan tidak hanya sebagai bentuk kebertahanan bahasa konjo dalam bidang pertambakan, tetapi diharapkan membangun model pembelajaran bahasa berbasis lingkungan. Luaran hasil penelitian berupa jurnal nasioanal dn buku ajar dan akan diimplementasikan pada mata kuliah ekolinguistik yang akan berorientasi pada kurikulum MBKM.
Kata Kunci: Workshop Kebertahanan, Kosakata, Bahasa Konjo, Pertambakan
Efficacy and safety of post-discharge oral nutritional supplements for patients with gastric cancer undergoing gastrectomy: a meta-analysis of randomized controlled trials
Authors: Liang Qiuman , Wang Siyi , Wang Beibei , Hong Yanyan 
Published: January 2025

ObjectivesTo report the first and largest systematic review and meta-analysis of randomized controlled trials (RCT) to evaluated the efficacy and safety of post-discharge oral nutritional supplements (ONS) for patients with gastric cancer undergoing gastrectomy.DesignSystematic review and meta-analysis.Eligibility criteria for selecting studiesRCT which evaluated the efficacy and/or safety of post-discharge ONS for patients with gastric cancer undergoing gastrectomy.Data sourcesWe conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane until April, 2023 for relevant RCTs.Data analysisOutcomes of meta-analysis included absolute change of body weight, % change of body weight, absolute change of body composition, absolute change of laboratory parameters and adverse events. All the relevant data were analyzed by Review Manager 5.4.1 and Stata 15.1.Results5 RCTs including 1,586 patients (804 in ONS group versus 782 in control group) were included for meta-analysis. The two groups were comparable in age, gender (male), weight at baseline, BMI at baseline, albumin at baseline, and hemoglobin at baseline. Meta-analysis revealed a significant lower absolute body weight loss (WMD: 0.75; 95% CI: 0.11, 1.40; p = 0.02) and % body weight loss (WMD: 1.15; 95% CI: 0.20, 2.11; p = 0.02) in the ONS group compared with the control (regular diet/dietary advice) group. Moreover, this study did not observe a significant difference between the two groups for adverse events rate (RR: 1.11; 95% CI: 0.81, 1.53; p = 0.52).ConclusionONS was significantly effective and safe in improving postoperative weight loss for patients with gastric cancer undergoing gastrectomy.Systematic review registrationIdentifier, CRD42023414678, https://www.crd.york.ac.uk/PROSPERO/.
Diagnostic performance of microRNAs for predicting response to transarterial chemoembolization in hepatocellular carcinoma: a meta-analysis
Authors: Huang Tianyi , Chen Jing , Zhang Lu , Wang Rui , Liu Yiheng , Lu Cuihua 
Published: January 2025

PurposeTo provide a detailed pooled analysis of the diagnostic accuracy of microRNAs (miRNAs) in predicting the response to transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC).MethodsA comprehensive literature search was conducted across PubMed, Embase, Cochrane Library, and Web of Science to identify studies assessing the diagnostic performance of miRNAs in predicting TACE response in HCC. Two independent reviewers performed quality assessment and data extraction using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the summary receiver operating characteristic (SROC) curve were calculated using a bivariate random-effects model. Subgroup analyses and meta-regression were performed to explore potential sources of heterogeneity, including sample size, response criteria, specimen source, response evaluation methods, TACE efficacy interval window, and geographical location.ResultsSeven studies, comprising 320 HCC responders and 187 non-responders, were included in this meta-analysis. The miRNAs studied included miR-373, miR-210, miR-4492, miR-1271, miR-214, miR-133b, and miR-335. The pooled sensitivity of miRNAs in predicting recurrence after TACE was 0.79 [95% CI: 0.72-0.84], and the pooled specificity was 0.82 [95% CI: 0.74-0.88]. The DOR was 17 [95% CI: 9-33], and the pooled area under the SROC curve (AUC) was 0.85 [95% CI: 0.81-0.88], indicating excellent diagnostic accuracy. Subgroup analyses revealed significant differences in diagnostic performance based on response criteria and geographical location. Meta-regression did not identify any significant sources of interstudy heterogeneity.ConclusionMiRNAs show promise as diagnostic tools for predicting TACE response in HCC patients. However, their clinical application requires further validation in larger cohorts. Future research should focus on standardizing RNA extraction methods, selecting consistent endogenous controls, and adopting uniform response evaluation criteria to improve reliability and reduce variability.
Microalga Nannochloropsis gaditana as a Sustainable Source of Bioactive Peptides: A Proteomic and In Silico Approach
Authors: Paterson Samuel , Alonso-Pintre Laura , Morato-López Esperanza , González de la Fuente Sandra , Gómez-Cortés Pilar , Hernández-Ledesma Blanca 
Published: January 2025

The impact of the world’s growing population on food systems and the role of dietary patterns in the management of non-communicable diseases underscore the need to explore sustainable and dietary protein sources. Although microalgae have stood out as alternative sources of proteins and bioactive peptides, some species such as Nannochloropsis gaditana remain unexplored. This study aimed to characterize N. gaditana’s proteome and evaluate its potential as a source of bioactive peptides by using an in silico approach. A total of 1955 proteins were identified and classified into functional groups of cellular components, molecular functions, and biological processes. In silico gastrointestinal digestion of identified proteins demonstrated that 202 hydrophobic and low-molecular-size peptides with potential bioactivity were released. Among them, 27 exhibited theorical antioxidant, antihypertensive, antidiabetic, anti-inflammatory, and/or antimicrobial activities. Seven of twenty-seven peptides showed ≥20% intestinal absorption, suggesting potential systemic effects, while the rest could act at local level. Molecular docking demonstrated strong affinities with key enzymes such as MPO, ACE, and DPPIV. Resistance to the digestion, capacity to be absorbed, and multifunctionality were demonstrated for peptide FIPGL. This study highlights N. gaditana’s potential as a sustainable source of novel potential bioactive peptides with promising local and systemic biological effects.
ANALISIS LAPORAN KEUANGAN PADA AKAD PEMBIAYAAN MURABAHAH BERDASARKAN PSAK 102 (STUDI KASUS : BAITUL MAAL TAMWIL (BMT) SYARIAH RIYAL (BSR) KABUPATEN BEKASI
Authors: Intishar Fathonah , Bianda Ryan , Muti Alwafa Ahmad 
Published: January 2025

Studi ini bertujuan untuk menganalisa laporan keuangan akad pembiayaan murabahah berdasarkan PSAK 102 dengan studi kasus pada BMT Syariah Riyal Kabupaten Bekasi. Studi ini merupakan penelitian kualitatif dengan metode teknik pengumpulan data yaitu wawancara, observasi dan dokumentasi. Studi ini bertujuan untuk menganalisa laporan keuangan pada akad pembiayaan murabahah di BMT Syariah Riyal. Namun pada faktanya perbankan syariah maupun lembaga keuangan syariah dalam penulisan kaporan keuangan pada akad murabahah belum sepenuhnya patuh terhadap PSAK 102 yang menjelaskan tentang akad murabahah. Studi ini memberikan bukti empiris dalam memahami penulisan laporan keuangan akad pembiayaan murabahah berdasarkan PSAK 102.
IMPLEMENTASI PROGRAM WAKAF SUMUR DESA TERPENCIL BINAAN DOMPET DHUAFA STUDI KASUS WAKAF SUMUR DI DESA CIOMAS BANTEN
Authors: Fadhillah Mulky Kautsar , Khotimah Husnul 
Published: January 2025

Waqf institutions in this case have a very important role in providing assistance to the less fortunate. One of the waqf institutions in Indonesia is Dompet Dhuafa. Dompet Dhuafa is a Nazhir Waqf Institution that focuses on developing productive and social waqf assets in Indonesia. Productive waqf which is currently being developed and is much needed by regions in Indonesia and in the world, especially wells. The purpose of this research is to find out the implementation of the well waqf program in the village of Ciomas, Banten. The method in this study uses a qualitative descriptive method. Qualitative research methods are research that describes situations or events. The data sources used in this research are primary data and secondary data. Data collection techniques are carried out by observation, interviews, and documentation. The results showed that: (1) The implementation of well waqf was carried out by Dompet Dhuafa in Ciomas Banten through several processes, namely collection, management of implementation, and monitoring of evaluation. Fundraising of waqf resources is a basic step that must be considered by nazhir for the implementation of waqf. Dompet Dhuafa Banten is able to obtain funds of around IDR 4.2 billion per year. As much as 30% of the total collection of funds in Dompet Dhuafa Banten is used for waqf such as the well waqf program built in Ciomas Banten. In carrying out the management and implementation process up to the point where the results obtained from the management of productive waqf cannot be separated from the importance of the current waqf institution, namely Dompet Dhuafa. The implementation of waqf wells in Ciomas Banten is carried out by preparing waqf target locations because well waqf is universal. What Dompet Dhuafa has done in implementing productive waqf to provide welfare for the people in the form of waqf wells is in accordance with what is intended in Law Number 41 of 2004 contained in article 22 which has point 1 namely a Nazhir when he wants to distribute productive waqf that has been produce, then in distributing it for religious facilities and activities as has been done by Dompet Dhuafa in implementing productive waqf assets in the form of religious facilities and activities, Dompet Dhuafa makes waqf wells. (2) The waqf well in Ciomas Banten is very beneficial for the surrounding community. The benefits of waqf for the welfare of the people, that is, waqf has no limits. The Ciomis community stated that they often experience water shortages, the community only relies on nearby water sources such as rice fields. However, after the existence of this waqf well, the community can meet the water needs of the pilgrims, this waqf well can also be utilized by the general residents of this area, numbering around 72 people.
Simuler pour comprendre : un didacticiel pour l'apprentissage de notions de base en statistique inférentielle
Authors: Palm Rodolphe , Allagbe Germain 
Published: January 2025

Un didacticiel, intitulé «Probabilité et Statistique : simuler pour comprendre », est proposé aux étudiants pour les aider à comprendre diverses notions de base de la statistique. Ces notions sont présentées à l’aide de résultats de simulations, ce qui permet de les rendre plus concrètes. Le didacticiel se compose des huit modules suivants :
− notion de probabilité ;
− variable aléatoire discontinue et distribution de probabilité ;
− variable aléatoire continue et distribution de probabilité ;
− propriétés relatives aux sommes de variables ;
− distribution d’échantillonnage de la moyenne ;
− estimation d’un paramètre ;
− intervalle de confiance d’une moyenne ;
− test de conformité d’une moyenne. Il fonctionne avec le navigateur Internet Explorer et est accessible à partir du site http ://www.fsagx.ac.be/si/ en cliquant sur le lien « Didacticiel et QCM » figurant dans le plan de ce site.
Le commandeur de Nieuport et Jean-Guillaume Garnier : deux adeptes de la théorie des probabilités présentée sous forme d’un feuilleton
Authors: Droesbeke Jean-Jacques 
Published: January 2025

The Commander of Nieuport and Jean-Guillaume Garnier : two followers of probability theory presented in the form of a serial.
The Commander of Nieuport and Jean-Guillaume Garnier are the first two people who wrote texts on probability theory in Belgium. The purpose of this paper is to present the most striking characteristics of these authors and their publications.
Fabriquer le chiffre des insensés : socio-histoire de la quantification de la folie au XIXe siècle (conventions, mesures et transformations)
Authors: Hervois Pauline 
Published: January 2025

In the 19th century, two sources of statistical data report the number of people suffering from insanity and living in their homes : the quinquennial censuses (from 1851 to 1876) and reports on military recruitment. This article proposes to first go back over the process of producing this figure from medical and administrative classifications and collection operations, and then to discuss the consequences of producing these figures in society. In other words, in a socio-historical approach the article proposes to show what the quantification of madness says about
society and what it says to society.