bluuebunny/crossref_metadata_2025_split huggingface dataset:
LIKELIHOOD OF ADOPTION OF CAREMOBI: ADDRESSING COMMUNICATION GAPS BETWEEN ADULT DAY HEALTH CENTERS AND PRIMARY CARE
Authors: Ali Zuha , Sadarangani Tina 
Published: December 2022

Abstract
Adult Day Health Centers (ADHC) are non-residential congregate facilities that serve 250,000 cognitively and functionally impaired adults daily. These centers are effective platforms for chronic disease management and interdisciplinary care coordination, with serial observations on participants over multiple hours and days per week. However, previous research indicates that ADHCs experience challenges in communication with primary care providers (PCPs). This is because 92% of ADHCs lack interoperable EHRs (electronic health record systems) and do not have the financial and technical infrastructure to implement them. CareMOBI (Mhealth for Organizations to Bolster Interconnectedness) is a mobile application in development meant to streamline the information communication between ADHC, PCP, and family caregiver populations. The purpose of this study was to understand the likelihood of adoption of CareMOBI by primary care providers. Demographics of the study included 87.50% female and 12.5% male primary care providers with a median age of 38 years. Participants were recruited through parallel convergent design, and data was merged into a matrix defined by 4 major themes: perceived value in geriatric care, ease of use, fit within workflow, and likelihood of adoption. The results revealed that a majority percentage of providers were likely to adopt the app, saw the app as valuable, and easy to use. In response to fit within a provider’s workflow, apprehensions surrounding interoperability arose. These apprehensions regarding interoperability are the most important to address through a user-centered approach and as the app is pilot tested into adult day health centers.
ASSESSING THE NIH TOOLBOX EMOTION BATTERY AMONG PEOPLE AGING WITH HIV AND WHO USE METHAMPHETAMINES
Authors: Bender Alexis , Cooper Hannah L F , Moore David , Perkins Molly , Haardoerfer Regine 
Published: December 2022

Abstract
Measurement of social relationships is challenging because constructs have dimensions that can be assessed at multiple levels. Consequently, researchers often operationalize social relationships differently, making it difficult to compare results with the same outcome across studies. The National Institutes of Health (NIH) commissioned the Toolbox Assessment of Neurological and Behavioral Function to create a set of harmonized measures to use across studies. The NIH Toolbox-Emotions Battery (NIHTB-EB) was normed in English and Spanish-speaking populations, which found support for a three-factor structure (negative affect, social satisfaction, and psychological well-being). Here we investigated the factor structure of the NIHTB-EB among a sample of 862 people aged 17 to 82 with and without HIV and methamphetamine use in comparison to the factor structure found in the NIH Toolbox norming project. Initial confirmatory factor analysis did not support the three-factor structure identified previously for the full sample or subsamples. Subsequent exploratory factor analyses showed a good model fit for a four-factor solution for the full sample, with slight variations in factor loading across subgroups. In addition to the three factors described in the norming project, our solution contains an additional factor, “rejection and hostility,” which includes scores from social satisfaction and negative affect in the normative population. The four-factor solution will be utilized for subsequent analyses using the NIHTB-EB in these study samples. Our analyses highlight the importance of assessing measures in distinct sub-populations to understand possible challenges to measurement invariance and ultimately allow the use of NIHTB-EB across groups.
LONELINESS IN LGBTQIA+ OLDER ADULTS: A SCOPING REVIEW
Authors: Bowers Katherine , Carpenter Joan , Thornton Marleen , Fetting Hannah , Johnson Erin 
Published: December 2022

Abstract
Loneliness in older adulthood is responsible for poor mental and physical health, cognitive decline, and early mortality. Older adults in the LGBTQIA+ community experience additional layers of vulnerability, such as discrimination, higher rates of childlessness, health inequity, and economic disparity that place them at high risk for loneliness. The purpose of this scoping review is to explore the existing literature on loneliness in LGBTQIA+ older adults and identify knowledge gaps to inform future research recommendations. Using the Arskey & O’Malley methodological framework, our team searched PubMed, Embase, CINAHL, PsychINFO, Scopus, and Google Scholar using keywords related to older adults, sexual and gender minorities, and loneliness. We identified 61 articles from 1980 to 2022. Most of the research in this literature reflected studies using descriptive and qualitative approaches. Intervention studies were the least reported. One opinion piece is included. Initial findings highlight associations between discrimination and loneliness, poor mental health and loneliness, the challenges of HIV in older adulthood and loneliness, and loneliness experienced in caregiving and end of life in LGBTQIA+ older adults. Importantly, many studies emphasized the protective nature of strong social support and community ties against loneliness. Equally, the literature suggests that limited social support is a significant risk factor for loneliness in this population. Older gender non-binary and LGBTQIA+ people of color were underrepresented in many studies. Future research should include intervention research that targets loneliness in this population as well as studies focused on understanding loneliness more comprehensively in underrepresented LGBTQIA+ older adults.
HEALTH INFLUENCES OF UNIQUE AND INTERSECTING IDENTITIES: AGE, SEXUAL ORIENTATION AND RACE
Authors: Bernstein Laura , Patrick Julie 
Published: December 2022

Abstract
Lesbian, gay, and bisexual older adults are an understudied group with limited research using nationally representative samples. Although there are known physical health disparities based on age, sexual orientation, and race, the effects of intersecting identities have not been fully examined. We were interested in how these identities individually influence health and whether they interact to effect physical health. Using the 2020 Behavioral Risk Factor Surveillance System (M age = 54.30, SD = 17.52), we examined whether sexual orientation was related to the number of poor physical health days experienced and whether that relation was moderated by age and race. The overall model was significant (F (5, 223356) = 511.86, p &lt; .001, R2 = .0113). Significant direct effects of sexual orientation and race emerged, but these were qualified by a significant sexual orientation by race interaction (b = -.09) A significant main effect emerged for age (b = 1.08) but the sexual orientation by age interaction failed to reach significance. There was a significant three-way interaction between age, race, and sexual orientation (F (2, 223356) = 6.34, p &lt; .01). Investigation into the means found that multiracial adults tend to report more poor health days than White, Black, or Hispanic adults, except for bisexual older and younger adults. These results highlight the importance of examining intersecting identities when trying to understand health disparities across the lifespan. Understanding how these identities interact helps to identify specific barriers these groups face and ultimately improve health equity, specifically in an aging population.
COMORBIDITIES ASSOCIATED WITH RISK OF MYOCARDITIS IN HOSPITALIZED COVID-19 OLDER ADULTS
Authors: Crawford Andrew , Redondo Andres , Zadeh Ali Vaeli , Wong Alan , Carrero Ricardo Criado , Fleischhacker Alexander , Collado Elias , Larned Joshua 
Published: December 2022

Abstract

Background
Older adults are afflicted more severely by COVID-19. SARS-CoV-2 can be complicated by myocarditis (MC), and the incidence of MC has been shown to correlate linearly with severity. However, data on comorbidities associated with MC in this population is scarce.

Methods
Data were obtained from the PearlDiver database (PearlDiver Technologies, Fort Wayne, IN). The study used ICD codes to include patients hospitalized with a primary diagnosis of COVID-19, aged 65–75, and Elixhauser Comorbidity index(ECI)&gt;4. Within this cohort, we identified patients diagnosed with MC 60 days after admission and compared their baseline comorbidities upon admission to those without MC. Pearson’s chi-squared test was used to compare groups. The strength of association was reported by Risk Ratios (RR). A p-value &lt; 0.05 was deemed significant.

Results
412,582 patients admitted with COVID-19 as the primary diagnosis were identified. 0.12% of this cohort developed MC over the following 60 days. The MC group was more likely to be male(57%, p=0.0001), with similar mean age(70.4, p=0.86) and mean ECI(9.4, p=0.07) to the no-MC group. Patients who developed MC have significantly higher rates of prior heart failure(RR= 1.30, CI95%=1.07–1.57, p=0.008). There was no difference between groups in terms of history of arrhythmias(p=0.36), cerebrovascular disease(p=0.09), chronic kidney disease(p=0.13), CAD(P=0.19), diabetes(p=0.48), ischemic heart disease(p=0.06), tobacco use(p=0.39), alcohol use(p=0.17), HIV(p=0.79), and severe liver disease(p=0.14).

Conclusion
A history of heart failure increased the likelihood of developing MC in older adults.
OLDER ADULT CAREGIVERS’ THOUGHTS ON WOUND CARE RESOURCES
Authors: Swartzell Kristen , Fulton Janet , Von Gaudecker Jane 
Published: December 2022

Abstract
As healthcare increasingly shifts to home and community-based settings, informal caregiver responsibilities are increasing beyond assistance with activities of daily living to include complex care procedures previously performed by licensed caregivers in clinical settings. With an aging population, increasing numbers of older adults are assuming a caregiving role and these older adult caregivers are performing complex care procedures such as wound care. The negative physical and mental health consequences of caregiving for older adult caregivers are well documented in the literature. However, access to and use of resources are associated with better physical and mental health. Past research on caregiving resources has utilized pre-determined resource variables. Little is known about older adult caregivers’ salient thoughts on resources important to caregiving and performing complex care procedures. This study utilized thematic analysis of qualitative interview data to identify themes and patterns related to resources as described by older adult caregivers. The following seven themes related to resources needed or utilized were identified: 1) expert guidance from healthcare professionals; 2) written instructions; 3) relationships with healthcare professionals for obtaining wound care supplies; 4) additional durable medical equipment; 5) financial resources; 6) coverage for caregiver personal time; and 7) select persons for social and emotional support. Older adult caregivers need and use a variety of resources when providing wound care. As increasing numbers of older adults choose to ‘age in place’, the importance of adequate resources to sustain care recipients and their caregivers in the home setting is critical.
A LIVE ONLINE EXERCISE PROGRAM FOR OLDER ADULTS’ IMPROVED DEPRESSIVE SYMPTOMS: A PILOT RCT
Authors: Coletta Giulia , McQuarrie Angelica , Delvecchio Julia , Bochnak Paula , Griffin Meridith , Tang Ada , Phillips Stuart 
Published: December 2022

Abstract
Exercise improves mental health and effectively alleviates cognitive and physical declines. Unfortunately, engagement in physical activity decreases as individuals age and this was likely exacerbated by the COVID-19 pandemic. New technologies to deliver live online home-based group exercise classes may help mitigate mental and physical health declines in older adults while maintaining social connectivity. We evaluated the feasibility of an age-appropriate and ability-modified at-home exercise program via live video stream. The impact on loneliness, anxiety, and depression in older adults were exploratory outcomes. In this two-arm pilot RCT, we randomly assigned sedentary community-dwelling adults (65-80 years) to a waitlist control (CON) or an active group (ACTIVE) of thrice-weekly, 8-wk online live exercise program delivered via Zoom by trained exercise professionals. Attendance was recorded, and participant satisfaction to ACTIVE was assessed. Pre- and post-intervention loneliness, anxiety, and depression were collected using the revised UCLA Loneliness Scale (R-UCLA), the Geriatric Anxiety Inventory (GAI), and the Geriatric Depression Scale (GDS). 32 participants were randomized (ACTIVE: n=16, mean age 70 ± 4, 69% women, 30 ± 5 kg/m2; CON: n=16, mean age 71 ± 5; 88% women; 29 ± 5 kg/m2). Attendance to online classes was &gt;80% and all ACTIVE participants reported being satisfied with the exercise sessions. There was no intervention effect compared to CON on loneliness and anxiety. An effect of the intervention was observed for depression (ACTIVE: -1.94; CON: -0.07; p=0.015). We demonstrated good feasibility, satisfaction, and preliminary efficacy of a live online exercise program on older adults’ mental health.
Mechanisms by Which Cultural-Centric Narrative Influences Interest in ADRD Research Among African American Adults
Authors: Lingler Jennifer H , Ren Dianxu , Tamres Lisa K , Knox Melissa L , Mbawuike Uchenna , Williams Ishan C , Robinson Renã A S , Cameron Judy L , Terry Melita H , Garrett Marita 
Published: December 2022

Abstract

Background and Objectives
Insufficient ethnoracial diversity is a pervasive challenge in Alzheimer’s disease (AD) research. The Recruitment Innovations for Diversity Enhancement (RIDE) is grounded in the premise that culturally informed narratives of research participation can inspire individuals from a given culture-sharing group to consider research enrollment. This study examines factors associated with interest in AD research among Black or African American adults following exposure to RIDE narrative campaign materials.

Research Design and Methods
A community-based sample of 500 Black or African American adults viewed RIDE narrative materials online and completed a survey of perceptions about research, AD risk, and likelihood of enrolling in AD research. Logistic regression examined predictors and mediators of self-reported likelihood of participating in AD research.

Results
Most (72%) participants reported interest in being contacted for AD research opportunities. After controlling for key variables, prior experience with clinical research and trust in medical researchers emerged as independent predictors of likelihood of enrolling in AD research. Perceived burden of AD research partially mediated the effects of prior research experience and trust on likelihood of enrollment. Perceived benefits of AD research also played a mediating role, accounting for over one third of the effect of trust on likelihood of enrollment.

Discussion and Implications
This study advances the field’s understanding of how narrative may function to enhance diversity in AD research. Findings suggest that participant narratives should address experiences regarding the burdens and potential benefits of AD research participation as these factors may influence decisions leading to subsequent research enrollment.
Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility)
Authors: Brayton Cory F 
Published: December 2022

Abstract
Laboratory registration codes, also known as laboratory codes or lab codes, are a key element in standardized laboratory animal and genetic nomenclature. As such they are critical to accurate scientific communication and to research reproducibility and integrity. The original committee on Mouse Genetic Nomenclature published nomenclature conventions for mice genetics in 1940, and then conventions for inbred strains in 1952. Unique designations were needed, and have been in use since the 1950s, for the sources of animals and substrains, for the laboratories that identified new alleles or mutations, and then for developers of transgenes and induced mutations. Current laboratory codes are typically a 2- to 4-letter acronym for an institution or an investigator. Unique codes are assigned from the International Laboratory Code Registry, which was developed and is maintained by ILAR in the National Academies (National Academies of Sciences Engineering and Medicine and previously National Academy of Sciences). As a resource for the global research community, the registry has been online since 1997. Since 2003 mouse and rat genetic and strain nomenclature rules have been reviewed and updated annually as a joint effort of the International Committee on Standardized Genetic Nomenclature for Mice and the Rat Genome and Nomenclature Committee. The current nomenclature conventions (particularly conventions for non-inbred animals) are applicable beyond rodents, although not widely adopted. Ongoing recognition, since at least the 1930s, of the research relevance of genetic backgrounds and origins of animals, and of spontaneous and induced genetic variants speaks to the need for broader application of standardized nomenclature for animals in research, particularly given the increasing numbers and complexities of genetically modified swine, nonhuman primates, fish, and other species.
Amyloid deposition at the carotid artery in an ATTRwt amyloidosis patient: a case report
Authors: Ozaki Hirokazu , Mitsui Nobuyuki , Kinoshita Manabu , Tanino Mishie , Kimura Teruo 
Published: December 2022

Abstract
Systemic amyloidosis is a diseased condition where misfolded proteins deposit in various organs in the form of amyloids, and transthyretin deposition, termed ATTR amyloidosis, can be either an age-related amyloid formation from misfolded wild-type TTR (ATTRwt) or by hereditary TTR malfunction due to mutation in the TTR gene (ATTRv). Although ATTRwt amyloidosis can cause various diseases, such as cardiac failure, conduction disturbances, arrhythmias and carpal tunnel syndrome, it is still under-recognised considering its clinical significance. Here the authors report a case of ATTRwt amyloidosis leading to carotid stenosis requiring surgical intervention. To the best of our knowledge, the current report is the first that described histopathological evidence of amyloid deposition in the carotid artery due to ATTRwt amyloidosis.
Bowel perforation surgery due to fecal impaction immediately after hernia mesh surgery (TAPP)
Authors: Choi Jung Bum , Lee Byoung Chul , Han Jeong Hee , Noh Byeong Gwan , Park Jae Kyun , Park Young Mok , Jung Hyuk Jae , Jo Hong Jae 
Published: December 2022

Abstract
Inguinal hernia repair using prosthetic mesh is used as a standard treatment in most countries and considered superior to primary suture repair. Although prosthetic mesh has greatly reduced the risk of recurrence, the risk of mesh infection remains. A 71-year-old man was diagnosed with symptomatic bilateral inguinal hernias. He underwent successful laparoscopic transabdominal preperitoneal (TAPP) repair and was discharged the same day. After 3 days, he was diagnosed with small bowel perforation, and underwent emergency surgery. We found perforation of the distal ileum caused by the fecal impaction and severe intra-abdominal contamination. We performed subtotal colectomy and ileosigmoid anastomosis, but did not remove the prosthetic mesh because the previous TAPP site was intact. The patient recovered well post-operatively. Therefore, contaminated or dirty surgery immediately after the hernia mesh surgery could be a feasible treatment.
Carbon and nitrogen remobilization during seed filling in Arabidopsis is strongly impaired in thepyrroline-5-carboxylate dehydrogenasemutant
Authors: Dourmap Corentin , Marmagne Anne , Lebreton Sandrine , Clément Gilles , Guivarc’h Anne , Savouré Arnould , Masclaux-Daubresse Céline 
Published: December 2022

AbstractProline is an amino acid that is degraded in the mitochondria by the sequential action of proline dehydrogenase (ProDH) and pyrroline-5-carboxylate dehydrogenase (P5CDH) to form glutamate. We investigated the phenotypes of Arabidopsis wild-type plants, the knockout prodh1 prodh2 double-mutant, and knockout p5cdh allelic mutants grown at low and high nitrate supplies. Surprisingly, only p5cdh presented lower seed yield and produced lighter seeds. Analyses of elements in above-ground organs revealed lower C concentrations in the p5cdh seeds. Determination of C, N, and dry matter partitioning among the above-ground organs revealed a major defect in stem-to-seed resource allocations in this mutant. Again surprisingly, defects in C, N, and biomass allocation to seeds dramatically increased in high-N conditions. 15N-labelling consistently confirmed the defect in N remobilization from the rosette and stem to seeds in p5cdh. Consequently, the p5cdh mutants produced morphologically abnormal, C-depleted seeds that displayed very low germination rates. The most striking result was the strong amplification of the N-remobilization defects in p5cdh under high nitrate supply, and interestingly this phenotype was not observed in the prodh1 prodh2 double-mutant irrespective of nitrate supply. This study reveals an essential role of P5CDH in carbon and nitrogen remobilization for reserve accumulation during seed development in Arabidopsis.
A rare case of POEMS syndrome presenting as essential thrombocythemia
Authors: Angeloudi Elena , Pappi Eleni , Liakos Aris , Mainou Maria , Vlachaki Efthymia , Bekiari Eleni 
Published: December 2022

ABSTRACTPolyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) is a rare paraneoplastic syndrome, and its diagnosis is based on a series of clinical and laboratory findings. We present the case of a 46-year-old woman who was previously diagnosed with essential thrombocythemia. The patient complained about dyspnea on exertion, nausea, burning of the lower limbs, weight loss, recurrent episodes of lower back pain and polymenorrhea. Physical examination revealed hyperpigmentation, livedo reticularis of the lower limbs, sclerodermoid changes and plectrodactyly. A computed tomography-guided bone biopsy revealed the presence of plasmacytoma, and based on a combination of clinical features such as polyneuropathy, a diagnosis of POEMS syndrome has been established. The diagnosis of POEMS syndrome demands a high index of suspicion, especially in cases of peripheral neuropathy, peripheral edema or organomegaly of unknown origin. Since the syndrome can be fatal, early diagnosis is pivotal for patients’ survival and quality of life.
Subcutaneous-implantable cardioverter defibrillator lead dislodgement in a juvenile catecholamine-induced polymorphic ventricular tachycardia patient
Authors: Miyoshi Miwa , Saeki Hajime , Arita Yo , Iida Yoshinori , Fukui Tomoki , Yamamoto Shohei , Shichijo Kana , Suetani Yuto , Hirose Kosuke , Kuramoto Miho , Ogasawara Nobuyuki 
Published: December 2022

ABSTRACT
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a relatively rare inherited arrhythmic disease that causes sudden cardiac death, and is caused by mutations in the cardiac ryanodine receptor (RyR2) or sarcoplasmic reticulum protein calsequestrin 2 gene (CASQ2). A 16-year-old man was diagnosed with CPVT and was implanted with a Subcutaneous-implantable Cardioverter Defibrillator (S-ICD), but defibrillation electrode detachment occurred early after placement. We suspected that a two-incision technique was the possible cause. We also report on changes in surface ECG in remote monitoring of the device.
TAKE HOME MESSAGE
Although two-incision techniques are becoming the mainstream method of S-ICD implantation, we should consider that the three-incision technique may be advantageous in highly active patients.
Remote monitoring may also be useful for early detection of S-ICD dislodgement.