bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Speed Agility Training and Quickness on Speed Enhancement and Agility: an Experimental Study
Authors: Wijaya Furqon Fauzi , Pungki Indarto  
Published: May 2023

This research was conducted at Senior High School 1 Wonogiri. The sample taken was the women's futsal extracurricular group of Senior High School 1 Wonogiri which totaled 17 students. The data collection technique used is the use of tests and measurements. As for the measurement test procedure, researchers use Speed and agility measurement tests. The test instruments used are the 30 meter running test and the shuttle run. Hasil of this study obtained the value of sig. (The 2-tailed) the treatment group was 0.000. The value of the sig. The (2-tailed) treatment group < 0.05 showed that there was a significant difference between the initial test and the final test. So it can be concluded that speed agility and quickness training affects the level of speed and agility of the women's futsal extracurricular group of Senior High School 1 Wonogiri.
Introduction: Shakespeare and Montaigne: A Critical History
Authors: Hamlin William M. 
Published: May 2023

Hamlin’s introduction traces the history of critical debate on literary connections between Shakespeare and Montaigne from its beginnings in the late eighteenth century up through important recent discussions by Terence Cave, Peter Mack, Lars Engle, Warren Boutcher, Stephen Greenblatt, Peter Platt, and Colin Burrow. Examining the multiple forms of evidence used to support claims of literary influence, Hamlin asks what ‘source study’, ‘verbal borrowing’, and ‘conceptual indebtedness’ might mean and summarizes many instances of Shakespearean interpretation which hinge on the assumption that the English playwright acquired significant familiarity with the writings of the French essayist. Hamlin also discusses John Florio’s English translation of Montaigne’s Essays, first published in 1603, and he touches on early references to Montaigne by Sir William Cornwallis which bear on the question of whether there might have been translations other than Florio’s that aided the dissemination of Montaignian thought in early modern England.
Radical Neo-Paganism: The Transmission of Discontinuous Identity from Plutarch to Montaigne to Shakespeare’s Antony and Cleopatra
Authors: Vitkus Daniel 
Published: May 2023

The chapter traces the transmission of a fundamental philosophical concept, what Jonathan Dollimore has called “discontinuous identity.” This concept was defined by ancient philosophers and is found in Plutarch’s writings. Later it became a part of Montaigne’s early modern description of selfhood in his “Apology for Raymond Sebond.” It then appears in Shakespeare’s Antony and Cleopatra as a form of theatrical character. Through the adaptive strategies of Montaigne and Shakespeare’s Renaissance humanism, a modern definition of subjectivity and consciousness emerges. Shakespeare’s dramatization of discontinuous identity and neo-pagan materialism in Antony and Cleopatra is deployed, the chapter argues, to question certain aspects of conventional Christian teaching that promote monotheism and autocratic authority. Instead, Shakespeare’s tragedy points the way toward a modern materialism that rejects essence, celebrates flux, and declares all matter sacred.
OPTIMALISASI TEKNOLOGI INFORMASI DAN KOMUNIKASI DI SMK MUHAMMADIYAH HARUMANSARI
Authors: Dian Nursantika  , Dwi Astuti Aprijani  , Dian Nurdiana  , Andri Suryadi  
Published: May 2023

Kegiatan pengabdian kepada masyarakat (PkM) Program Studi Sistem Informasi Universitas Terbuka bertujuan untuk membantu mengatasi masalah yang ditemui di masyarakat, dengan menerapkan ilmu bidang teknologi informasi dan komunikasi (TIK). Kebutuhan untuk memanfaatkan TIK dalam menyelesaikan masalah administrasi dan pembelajaran sangat dibutuhkan, terutama di sekolah-sekolah, termasuk Sekolah Menengah Kejuruan (SMK) Muhammadiyah Harumansari yang berada di wilayah Garut. Untuk meningkatkan keterampilan tenaga pendidik dan guru dalam memanfaatkan TIK, SMK Muhammadiyah Harumansari bekerja sama dengan Program Studi Sistem Informasi Universitas Terbuka yang diwujudkan dalam kegiatan PkM. Tujuan PkM adalah untuk: (1) meningkatkan kemampuan tenaga pendidik dan guru dalam memanfaatkan Microsoft Office; (2) memberikan pelatihan membuat daftar isi secara otomatis dan membuat mail merge sederhana menggunakan Ms Word; (3) memberikan pengenalan dasar Ms Excel, yang terdiri dari operator, fungsi perhitungan, fungsi logika, dan fungsi lookup; (4) membuat slide presentasi menggunakan Ms PowerPoint. Strategi yang dilakukan adalah langsung mempraktikkan menggunakan Microsoft Office di komputer dan memberikan contoh fungsi-fungsi atau fitur-fitur yang digunakan terkait masing-masing materi. Meskipun pelatihan dilakukan secara daring, namun tidak mengurangi kualitas penyampaian pembelajaran, karena peserta dapat langsung mencoba dan dapat menunjukkan hasil kerjanya kepada tim PkM melalui share screen dan tugas individu. Dampak dari kegiatan PkM ini adalah tenaga pendidik dan guru di SMK Muhammadiyah Harumansari mendapat pengetahuan praktis pemanfaatan Microsoft Office, yang dapat digunakan untuk meningkatkan kinerjanya serta dapat digunakan pada kegiatan sehari-hari dalam menunjang pekerjaannya sebagai tenaga pendidik dan guru.
PENDAMPINGAN PEMBUATAN HERBARIUM KERING PADA GURU SD DI KECAMATAN MINASATE’NE KABUPATEN PANGKEP
Authors: Makkatenni  , Jalil  , Husnaeni  , Rustam  , Avelyn Pingkan Komuna  
Published: May 2023

Kecamatan Minasate’ne merupakan salah satu kecamatan yang ada di wilayah Kabupaten Pangkajene dan Kepulauan (Pangkep) yang berjarak sekitar 47 km dari Kantor UPBJJ-UT Makassar kearah utara atau sekitar 1 km dari Pangkajene ibu kota Kabupaten Pangkep. Pemberdayaan masyarakat tentang pendampingan pembuatan herbarium kering pada guru SD di Kecamatan Minasate’ne Kabupaten Pangkep yang dilaksanakan dengan tujuan mendapatkan pengetahuan dan keterampilan tentang:(1) pengertian herbarium (2) cara pembuatan herbarium kering dan (3) praktik pembuatan herbarium kering. Kegiatan pengabdian masyarakat dilaksanakan selama satu tahun. Metode yang digunakan dalam kegiatan pengabdian ini adalah ceramah, tanya jawab dan demonstrasi tentang cara pembuatan herbarium kering. Kegiatan monitoring dan evaluasi dilaksanakan untuk melihat sejauh mana keberhasilan pengabdian masyarakat yang telah dialakukan khususnya pembuatan herbarium kering. Keterlaksanaan pengabdian kepada masyarakat didasarkan atas terpenuhinya indikator-indikator proses pengabdian masyarakat dan produk yang dihasilkan. Hasil evaluasi menunjukkan bahwa peserta sangat antusias dalam mengikuti pelatihan serta aktif dalam mengajukan pertanyaan pada saat pemaparan materi oleh nara sumber. Dapat disimpulkan bahwa pengabdian masyarakat telah diimplementasikan sesuai dengan rencana dimulai dari pengertian herbarium, cara pembuatan herbarium kering dan praktik pembuatan herbarium kering. Hal ini dapat dilihat dari keberhasilan peserta yang telah mengikuti kegiatan abdimas telah berhasil menerapkan pengetahuan dan pengalaman kepada teman sejawat, bahkan kepada murid-muridnya di kelas.Herbarium kering yang telah dibuat disimpan dalam bingkai dan album yang siap digunakan sebagai alat perga dalam mengajarkan IPA di SD.
REVITALISASI BUMDESA DALAM UPAYA PENGUATAN KELEMBAGAAN, PENGELOLAAN KEUANGAN DAN MANAJERIAL DI KABUPATEN LEBONG PROVINSI BENGKULU
Authors: Dwi Kristanti  , Abdul Aziz Zulhakim  , Mimi Kurnia Nengsih  
Published: May 2023

Kelegalitasan menjadi permasalahan yang dihadapi oleh pengelola BUMDesa, tidak terkecuali BUMDesa-BUMDesa yang berada di Kabupaten Lebong. Dari 93 BUMDesa yang ada, belum ada BUMDesa yang berbadan hukum jika dibandingkan dengan BUMDesa yang ada di berbagai Kabupaten di Provinsi Bengkulu. BUMDesa Sumber Urip Mangkurajo yang berada di Desa Mangkurajo dan BUMDesa Amanah Bersama merupakan BUMDesa yang di pandang cukup potensial di Kabupaten Lebong dilihat dari BUMDesa tersebut memiliki potensi yang cukup menjanjikan dan mendapat dukungan penuh dari Pemerintah setempat, namun belum memiliki badan hukum. Tahapan pelaksanaan yang dilakukan melalui 4 tahap yaitu pengidentifikasian masalah, pelatihan kelembagaan, keuangan dan manajerial, pendampingan pembuatan program kerja (Proker), serta pendampingan Pendaftaran Badan Hukum. Output dari kegiatan Abdimas ini yaitu Program Kerja dan Sertifikat Berbadan Hukum dari Kemenkumham. Pada kegiatan ini Tim melakukan pelatihan dan pendampingan di dua BUMDesa yang yang dinilai lebih baik dari diseleksi Tim dari 93 BUMDesa yang ada di Kabupaten Lebong. Namun pada tahap pendampingan pembuatan Proker BUMDesa Amanah Bersama memutuskan untuk belum melanjutkan ke Badan Hukum dikarenakan keterbatasan Sumber Daya Manusia. Pada tanggal 13 Juni 2022 pengajuan Badan Hukum BUMDesa Sumber Urip Mangkurajo disetujui oleh Kemenkumham yang disahkan dengan sertifikat nomor AHU-0426.AH.01.33 TAHUN 2022.
PEMBENTUKAN PUSAT KREATIF DESA MELALUI PEMBERDAYAAN PEMUDA DALAM MENGEMBANGKAN KETERAMPILAN PEMASARAN DIGITAL PRODUK UMKM DI DESA GEMBONGAN, KECAMATAN GEDEG, KABUPATEN MOJOKERTO
Authors: Tri Dyah Prastiti  , Yunianto Nugroho  , Dwi Sambada  , Suparti  , Barokah Widuroyekti  
Published: May 2023

Permasalahan seputar sosial ekonomi masih banyak ditemui di masyarakat, terutama di daerah pedesaan. Permasalahan tersebut, misalnya pengangguran, kemiskinan bahkan tindak kejahatan. Di sisi lain, selalu ada potensi yang bisa dikembangkan dari setiap desa baik berupa sumber daya manusia maupun sumber daya alam sebagai solusi dari permasalahan sosial dan ekonomi yang ada. Sayangnya sering kali masyarakat di desa belum mampu mengembangkan potensi-potensi tersebut karena belum memiliki ilmu, wawasan dan kreatifitas untuk mengelolanya. Kondisi saat ini wawasan tentang pasar dan kreatifitas biasanya dimiliki oleh para pemuda terutama golongan milenial. Namun banyak pemuda di Desa Gembongan tidak mendapatkan kesempatan atau dukungan untuk pengembangan potensinya. Padahal jika mereka diberi pelatihan dan pendampingan manajemen bisnis sosial digital dan wadah untuk berkreasi dan berkolaborasi terutama dengan usaha-usaha mikro, mereka pasti mampu mengembangkan potensi desanya. Sebagai solusi adalah memberikan wadah berupa Pusat Kreatif Desa, yang akan membuat proses bisnis yang dikembangkan menjadi ebih efektif karena adanya pembagian tugas melalui skema kolaborasi multi pihak. Kelompok pemuda yang dekat dengan perkembangan pasar dan teknologi saat ini bisa fokus berkreasi sebagai pengelola dan mengembangkan potensi industri-industri rumahan milik warga desanya yang kebanyakan lemah dalam hal manajemen. Untuk itu Pusat Kreatif Desa yang dikembangkan oleh dosen UT sebagai kegiatan abdimas perlu direalisasikan di Desa Gembongan, Gedeg, Mojokerto, Jawa Timur, mengingat Desa Gembongan memiliki potensi yang bisa dikembangkan dan sumber daya manusia yang bisa diberdayakan sebagai upaya untuk mengurangi permasalahan sosial di desa tersebut. Metode pelaksanaan meliputi 1) identifikasi masalah masyarakat di Desa Gembongan, riset potensi di Desa Gembongan dan sosialisasi mengenai konsep Pusat Kreatif Desa Gembongan; 2) pembekalan mengenai Bisnis Sosial Digital kepada para pemuda penggerak Pusat Kreatif Desa; 3) pendampingan kegiatan dan 4) evaluasi kegiatan. Hasil dan dampak terhadap pemuda desa Gembongan dari kegiatan ini yaitu para pemuda penggerak telah memiliki wadah berkreasi dan mampu memiliki keahlian yang diperlukan untuk membantu mengembangkan industri-industri rumahan yang ada di Desa Gembongan. Lebih lanjut diharapkan para pemuda di desa Gembongan bisa terus didukung untuk mampu mengembangkan perusahaan professional hasil dari mereka berkolaborasi dengan berbagai pihak.
Net cleaning impacts Atlantic salmon gill health through microbiome dysbiosis
Authors: Elsheshtawy Ahmed , Clokie Benjamin Gregory James , Albalat Amaya , Nylund Are , Isaksen Trond Einar , Napsøy Indrebø Elisabeth , Andersen Linda , Moore Lindsey Jane , MacKenzie Simon 
Published: May 2023

IntroductionNet biofouling has a significant impact for the global salmon industry in the seawater grow-out stage in terms of its management. Current mitigation strategies occur primarily through the regular removal of biofouling using in situ cleaning. While in situ net cleaning is effective there is uncertainty as to whether the equipment or dispersed material has an impact upon the fish in the cages. Through direct contact with the environment, the significant surface area of the gill including its microbiome is directly exposed to the acute environmental changes generated by net cleaning. This study aimed to provide a detailed understanding of the impact of in situ net cleaning on Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss) gill health.MethodsThree field trials were conducted on commercial fish farms in western Norway. Fouling organisms on net pens and flushed particles during in situ cleaning were identified and screened for major fish pathogens. Hydrographic profile measurements were performed to measure the impact on water quality. Gill samples were examined for histopathological changes, immune gene expression, and the prevalence of major pathogens. 16S rRNA amplicon sequencing was employed to explore the impact of net cleaning on gill microbiome.Results and discussionData obtained from these trials identified a diversity of fouling species including hydroids, algae, skeleton shrimps, and filter feeders on net pens, a direct impact on measured water quality indicators, a moderate change in gill inflammatory and antigen presentation activity at the level of mRNA, and a large significant change in gill microbiome. Observed changes in gill microbial community involved a decrease in bacterial richness coupled to an increase in identified bacterial genera related to negative health consequences. Parallel analyses for pathogens load in biofouling organisms and flushed particles highlighted the presence of several fish bacteria and parasites. However, minor changes were detected in salmon gill pathogen diversity and loading. Our results suggest that biofouling organisms may act as transient reservoirs for some fish pathogens but not viruses and that gill microbial dysbiosis could be related to the host stress response during and post net cleaning.
Shared Genetic Etiology of Primary Dilated Cardiomyopathy and Ischemic Dilated Cardiomyopathy
Authors: Sun Yang , Xiao Lei , Li Ke , Wang Hong , Song Xiuli , Li Zongzhe , Li Chenze , Chen Yanghui , Li Shiyang , Huang Jin , Tan Lun , Hu Dong , Yu Ting , Li Rui , Wang Hong , Jin Li , Shi Leming , Marian Ali J. , Wang Dao Wen 
Published: May 2023

Background: Mutations in genes encoding sarcomere and cytoskeletal proteins are major causes of primary dilated cardiomyopathy (DCM). Likewise, ischemic myocardial injury is a major cause of secondary cardiac remodeling, which, in a subset, is severe and resembles DCM. The latter is referred to as ischemic dilated cardiomyopathy (IDCM). We postulated the presence of pathogenic and likely pathogenic variants (PVs and LPVs, respectively) in genes known to cause primary DCM might predispose the heart to severe cardiac dilatation and dysfunction post myocardial ischemic injury, i.e., IDCM.Methods: We performed whole-exome sequencing in 1,041 patients with primary DCM, 215 patients with IDCM, and 414 healthy controls. Indices of cardiac size and function were similar between those with primary and ischemic DCM. PVs and LPVs, including the truncating variants in 36 genes known to cause primary DCM were identified and compared among the three groups.Results: Pathogenic variants and LPVs were detected in 266 individuals, comprised of 215/1,041 (20.7%) patients with DCM, 27/215 (12.6%) patients with IDCM, and 24/414 (5.8%) control individuals. PVs and LPVs in the TTN gene were the most common and detected in 130/1,041 (12.5%) of patients with DCM, 15/215 (7.0%) of cases with IDCM, and 10/414 (2.4%) control individuals. Of 135 TTNtv, 118 involved exons that were &gt;90% spliced in. These variants were found in 120/1,041 (11.5%) of DCM patients, 6/215 (2.8%) of IDCM cases, and only in 1/414 (0.2%) of the control population (p &lt; 0.001 among the three groups).Conclusions: Pathogenic variants and LPVs in genes known to cause primary DCM are enriched in patients with IDCM, suggesting that such variants function as susceptibility alleles for cardiac dilatation and dysfunction in post myocardial ischemic injury. Thus, IDCM shares a partial genetic etiology with the primary DCM.
Deep learning approach for analyzing chest x-rays to predict cardiac events in heart failure
Authors: Kusunose Kenya , Hirata Yukina , Yamaguchi Natsumi , Kosaka Yoshitaka , Tsuji Takumasa , Kotoku Jun’ichi , Sata Masataka 
Published: May 2023

BackgroundA deep learning (DL) model based on a chest x-ray was reported to predict elevated pulmonary artery wedge pressure (PAWP) as heart failure (HF).ObjectivesThe aim of this study was to (1) investigate the role of probability of elevated PAWP for the prediction of clinical outcomes in association with other parameters, and (2) to evaluate whether probability of elevated PAWP based on DL added prognostic information to other conventional clinical prognostic factors in HF.MethodsWe evaluated 192 patients hospitalized with HF. We used a previously developed AI model to predict HF and calculated probability of elevated PAWP. Readmission following HF and cardiac mortality were the primary endpoints.ResultsProbability of elevated PAWP was associated with diastolic function by echocardiography. During a median follow-up period of 58 months, 57 individuals either died or were readmitted. Probability of elevated PAWP appeared to be associated with worse clinical outcomes. After adjustment for readmission score and laboratory data in a Cox proportional-hazards model, probability of elevated PAWP at pre-discharge was associated with event free survival, independent of elevated left atrial pressure (LAP) based on echocardiographic guidelines (p &lt; 0.001). In sequential Cox models, a model based on clinical data was improved by elevated LAP (p = 0.005), and increased further by probability of elevated PAWP (p &lt; 0.001). In contrast, the addition of pulmonary congestion interpreted by a doctor did not statistically improve the ability of a model containing clinical variables (compared p = 0.086).ConclusionsThis study showed the potential of using a DL model on a chest x-ray to predict PAWP and its ability to add prognostic information to other conventional clinical prognostic factors in HF. The results may help to enhance the accuracy of prediction models used to evaluate the risk of clinical outcomes in HF, potentially resulting in more informed clinical decision-making and better care for patients.
Cardiomyopathy related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing
Authors: Pohl Greta Marie , Göz Manuel , Gaertner Anna , Brodehl Andreas , Cimen Tolga , Saguner Ardan M. , Schulze-Bahr Eric , Walhorn Volker , Anselmetti Dario , Milting Hendrik 
Published: May 2023

BackgroundArrhythmogenic cardiomyopathy can be caused by genetic variants in desmosomal cadherins. Since cardiac desmosomal cadherins are crucial for cell-cell-adhesion, their correct localization at the plasma membrane is essential.MethodsNine desmocollin-2 variants at five positions from various public genetic databases (p.D30N, p.V52A/I, p.G77V/D/S, p.V79G, p.I96V/T) and three additional conserved positions (p.C32, p.C57, p.F71) within the prodomain were investigated in vitro using confocal microscopy. Model variants (p.C32A/S, p.V52G/L, p.C57A/S, p.F71Y/A/S, p.V79A/I/L, p.I96l/A) were generated to investigate the impact of specific amino acids.ResultsWe revealed that all analyzed positions in the prodomain are critical for the intracellular transport. However, the variants p.D30N, p.V52A/I and p.I96V listed in genetic databases do not disturb the intracellular transport revealing that the loss of these canonical sequences may be compensated.ConclusionAs disease-related homozygous truncating desmocollin-2 variants lacking the transmembrane domain are not localized at the plasma membrane, we predict that some of the investigated prodomain variants may be relevant in the context of arrhythmogenic cardiomyopathy due to disturbed intracellular transport.
Adapting a mobile app to support patients with anorexia nervosa following post-acute care: perspectives from eating disorder treatment center stakeholders
Authors: Haas Anneliese , Laboe Agatha A. , McGinnis Claire G. , Firebaugh Marie-Laure , Shah Jillian , Bardone-Cone Anna M. , Pike Kathleen M. , Taylor C. Barr , Wilfley Denise E. , Fitzsimmons-Craft Ellen E. 
Published: May 2023

IntroductionAnorexia nervosa (AN) is a harmful, life-threatening illness. Patients with severe AN often receive acute treatment but, upon discharge, experience high relapse rates. Evidence-based, outpatient treatment following acute care is critical to preventing relapse; however, numerous barriers (e.g., location, financial limitations, low availability of providers) preclude individuals from accessing treatment. mHealth technologies may help to address these barriers, but research on such digital approaches for those with AN is limited. Further, such technologies should be developed with all relevant stakeholder input considered from the outset. As such, the present study aimed to garner feedback from eating disorder (ED) treatment center providers on (1) the process of discharging patients to outpatient services, (2) their experiences with technology as a treatment tool, and (3) how future mHealth technologies may be harnessed to offer the most benefit to patients in the post-acute period.MethodsParticipants (N = 11, from 7 ED treatment centers across the United States) were interviewed. To analyze the data for this study, each interview was manually transcribed and analyzed using components of Braun and Clarke's six-phase thematic analysis framework (Braun &amp; Clarke, 2006).ResultsParticipants indicated proactively securing outpatient care for their patients, but mentioned several barriers their patients face in accessing evidence-based ED treatment. All participants had some experience using various technologies for treatment (e.g., teletherapy, self-monitoring apps), and mentioned a high level of interest in the development of a new app to be used by patients recently discharged from acute treatment for AN. Participants also offered suggestions of effective and relevant content for a potential app and adjunctive social networking component for post-acute care of AN.DiscussionOverall, participants expressed positive attitudes toward the integration of an app into the care flow, suggesting the high potential benefit of harnessing technology to support individuals recovering from AN.