bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart Rate Variability Changes Across Menstrual Phases in Young Adults: An Autonomic Perspective
Authors: Mittal Yashvi , Vinay A V , Hirok C , Sreeshma P , Sindhu R , Suresh Konakanchi 
Published: February 2025

ABSTRACT

Introduction:
The menstrual cycle represents the intrinsic physiological rhythm experienced by females throughout their reproductive years. This intricate interplay of hormones orchestrates a profound influence on individuals, exerting substantial effects on both their physical well-being and emotional state. The menstrual cycle could also affect their degree of stress and autonomic functions which was not studied in detail. Therefore, this study aims to assess the changes in heart rate variability (HRV) during the menstrual, proliferative, and secretory phases of the menstrual cycle.

Materials and Methods:
Twenty-two female subjects aged 18–25 years with regular menstrual cycles were included in the study. The HRV was recorded thrice within a single menstrual cycle and the stress levels of the subject during the menstrual phase were assessed using a perceived stress scale (PSS) questionnaire.

Results:
The time domain parameters SDNN, NN50, pNN50, and RMSSD progressively decreased in the proliferative and secretory phases compared to the menstrual phase (P < 0.05). The mean RR interval decreased and the mean HR increased significantly in the secretory phase compared to the menstrual phase (P < 0.05). The PSS score during the menstrual phase was found to be 20.50 ± 2.35.

Conclusion:
Time domain parameters of HRV show a progressive decrease from day 1 to day 20 of the menstrual cycle. This pattern underscores a tilt of autonomic balance towards the sympathetic predominance as the cycle progresses from the menstrual phase to the secretory phase.
Prevalence of Vitamin D Deficiency and its Association with Thyroid Autoimmunity and Thyroid Hormones in Newly Diagnosed Patients with Autoimmune Thyroid Disease (AITD)
Authors: Sahoo Nihar R. , Pradhan Jeeban , Dash Deepak K. , Padhi Pradeep K. 
Published: February 2025

ABSTRACT

Objective:
To look for the prevalence of vitamin D deficiency (VDD) and its association with anti-TPO antibody and thyroid hormones (FT3, FT4, and TSH) levels in newly diagnosed patients with autoimmune thyroid disease (AITD).

Methods:
In this case-control study, new-onset AITD hypothyroidism/hyperthyroidism patients (anti-TPO-Ab levels >60 IU/ml) were recruited (n = 50). Fifty age, sex, and BMI-matched euthyroid healthy individuals were taken as controls. Detailed clinical examination and necessary investigations such as serum FT3, FT4, TSH, anti-TPO-Ab, 25 OHD (25 hydroxy vitamin D), and iPTH were measured.

Results:
The prevalence of VDD (25 OHD <20 ng/ml) was significantly higher in all AITD cases than that of controls (62% vs. 26%, P = 0.0003). No significant difference was found in the occurrence of VDD between hypothyroid and hyperthyroid AITD patients (69% vs. 50%, P = 0.189). AITD patients with VDD have significantly higher levels of anti-TPO-Ab (702.34 ± 498.54 IU/ml) as compared to vitamin D non deficient AITD subjects (234.64 ± 166.82 IU/ml) (P = 0.0003). Anti-TPO-Ab levels correlated inversely and significantly with 25 OHD levels among all AITD subjects (r = -0.610, P < 0.0001) without any significant correlation with thyroid hormones. Multiple linear regression analysis revealed that only serum 25 OHD had a significant inverse association with anti-TPO-Ab levels (β = -0.323; P = 0.036) but not with thyroid hormones.

Conclusions:
Vitamin D deficiency is commonly found in AITD patients. There is a significant negative association between vitamin D levels and anti-TPO-Ab titers suggesting a link between low vitamin D and AITD.
Interleukins Signature Profile in the Etiopathogenesis of Oral Submucous Fibrosis: A Comprehensive Study
Authors: Yadahalli Roopa , Sarode Gargi S. , Sarode Sachin C. , Vyas Nishant 
Published: February 2025

ABSTRACT

Objective:
Oral submucous fibrosis (OSMF) is a chronic progressive disorder of the oral cavity characterized by an increased malignant transformation rate. Understanding the pathogenetic components is crucial for the design and development of effective targeted therapies. Interleukins are a group of cytokines found to be altered in many fibrotic disorders of the oral cavity. Their signature in OSMF, especially at the tissue level, will help unveil novel pathogenesis and help in better understanding the disease.

Method:
For the current study, a total of 21 OSMF and 10 healthy participants were enrolled, and tissue samples were collected by incisional biopsy. The LEGENDplex™ Human Cytokine Panel 2 kit was used for the analysis of the cytokines with the help of flow cytometry. Interleukins analyzed included IL-1α, IL-1β, IL-12p40, IL-12p70, IL-15, IL-17, IL-18, IL-23, IL-27, and IL-33.

Results:
According to the study results, interleukin levels significantly increased during the early and late stages of the disease. IL-1α, IL-1β, IL-18, and IL-33 showed significant upregulation. Other interleukins such as IL-12p40, IL-12p70, IL-15, IL-17, IL-23, and IL-27 exhibited downregulation in late-stage OSMF.

Conclusions:
This study aids in associating the dynamics of cytokines with the stage of the disease, thus providing a comprehensive understanding of the individual effect of the cytokines on the progression.
Optimization of New Project Validation Protocols in the Automotive Industry: A Simulated Environment for Efficiency and Effectiveness
Authors: Lopes William Aparecido Celestino , Rusteiko Adilson Cunha , Mendes Cleiton Rodrigues , Honório Nicolas Vinicius Cruz , Okano Marcelo Tsuguio 
Published: February 2025

Increasing vehicle manufacturers has led to a considerable rise in the automotive industry's competitiveness. Various research projects are being developed to devise process optimization strategies using virtual simulation. The paper discusses the importance of applying modeling and simulation strategies to optimize automotive manufacturing processes to meet the demands of a constantly evolving market. The aim is to demonstrate a strategy divided into a few stages to optimize the process of validating new projects applied in the automotive industry. The methodology employed was computer modeling and simulation, which enabled identifying and eliminating risks inherent in the validation process, thereby reducing the time required to complete new projects. The results demonstrated that implementing this strategy facilitated an efficient transition of the validation process, maintaining the quality and safety standards required in the cell. Consequently, it can be posited that the methodology developed is an efficacious instrument for expediting the implementation of novel processes in automotive manufacturing, thereby contributing to the competitiveness and innovation of the industry in the automotive segment.

Received: 24 October 2024 | Revised: 10 December 2024 | Accepted: 9 January 2025

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.

Author Contribution Statement
William Aparecido Celestino Lopes: Conceptualization, Methodology, Validation, Investigation, Data curation, Writing – original draft, Writing – review & editing, Visualization. Adilson Cunha Rusteiko: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing – original draft, Writing – review & editing, Visualization. Cleiton Rodrigues Mendes: Conceptualization, Methodology, Software, Investigation, Resources, Writing – original draft, Writing – review & editing, Visualization. Nicolas Vinicius Cruz Honório: Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing, Visualization. Marcelo Tsuguio Okano: Validation, Formal analysis, Data curation, Supervision, Project administration.
MRI Study of Lumbar and Cervical Intervertebral Disc Degeneration – A cross sectional analysis.
Authors: Kirthika C P , KumarS Senthil , Venkata Sai P M 
Published: February 2025

Background Low back pain (LBP) is a condition characterized by degenerative changes in the spine, including intervertebral discs and ligaments. This degeneration leads to increased impairment, reduced productivity, and increased healthcare costs. Risk factors for disc degeneration include genetic factors, mechanical stress, and injury. Imaging procedures like X-rays, CT scans, and MRIs are used to diagnose intervertebral disc diseases.
Potato biofortification: game changer for micronutrient upliftment
Authors: Gupta Meenakshi , Srivastava Shipra , Gupta Sonam , Parveen Kahkashan 
Published: February 2025

Biofortification is an integrated approach to improve food's nutritional value, address common nutrient deficiencies, and support global food security. It was found through biofortification that the micronutrient concentrations were greatly enhanced by the application of zinc fertilizer. Long-term micronutrient availability may be possible with this sustainable, dependable, and reasonably priced method.
Estudo comparativo entre triagens farmacológicas de diferentes frações da Pereskia aculeata miller e da Alpinia zerumbet em ratos espontaneamente hipertensos
Authors: Lopes Alina Alves Almeida , Paulino Emanuel Tenório , Silva Jaciane Celestino da , Aguiar Julynne Elissa da Silva , Bernardino Alessandro Cesar , Melo Bruno Ithalo de Holanda , Silva Jessyka Carolina Galvão da , Ribeiro Êurica Adélia Nogueira 
Published: February 2025

A hipertensão é uma doença com alta prevalência, e é um dos principais fatores de risco para as doenças cardiovasculares. Muitos pacientes com hipertensão não atingem os níveis pressóricos ideais, é necessário buscar novas substâncias para o tratamento. Neste contexto, a Pereskia aculeata miller e Alpinia zerumbet são plantas medicinais utilizadas no tratamento da inflamação e hipertensão, respectivamente. Não há nenhum estudo científico que descreva a ação das frações destas plantas sobre o sistema cardiovascular. O objetivo deste trabalho foi avaliar os efeitos cardiovasculares induzidos pelas frações hexânica, precipitada insolúvel, diclorometano das folhas da P. aculeata e a fração acetato de etila das folhas da A. zerumbet em ratos espontaneamente hipertensos (SHR). Realizar uma pesquisa na literatura sobre os principais constituintes fitoquímicos presentes nestas plantas. Os SHR foram anestesiados e cateteres de polietileno foram inseridos no interior da aorta abdominal e veia cava inferior para medidas da pressão arterial média (PAM) e administração das frações (0,1; 0,5; 1; 5; 10; 20; 30; 40; 50 e 60 mg.kg-1 i.v., respectivamente). Após 24 horas, a PAM e frequência cardíaca foram registradas. Todas as frações induziram efeito hipotensor e bradicárdico. Os principais constituintes fitoquímicos da P. aculeata foram ácido caftárico quercetina e a rutina e da A. zerumbet, o 4-terpineol e kavaína. Podemos concluir que as respostas induzidas pelas frações da P. aculeata é provavelmente devido à atividade antioxidante dos seus constituintes e a fração da A. zerumbet é devido o bloqueio de canal para cálcio promovido pelos seus constituintes fitoquímicos majoritários.
Research on extraction and application of elements of Suzhou Subway public art design based on deep learning
Authors: Huang Yu 
Published: February 2025

Introduction: Public art in urban spaces enhances aesthetics, reflects cultural identity, fosters community engagement, and contributes to place making, transforming everyday environments into meaningful, interactive public experiences. Limitations include a lack of deep learning applications in extracting public art elements, limited exploration of cultural integration, and insufficient focus on interactive design methods.Methods: The proposed Great Cane Rat Algorithm-Tuned Scalable Generative Adversarial Network (GCR-SGAN) optimizes SGAN performance using GCRO for generating high-quality public art designs. The dataset includes images of public art, featuring murals, sculptures, and design elements for training and analysis. Histogram equalization will enhance image contrast, improving details, while Visual Geometry Group 16 (VGG16) feature extraction will capture high-level visual patterns and features, creating a robust representation for subsequent analysis and model training. The proposed work integrates SGAN for generating high-quality public art designs with GCR optimization to enhance GAN training, improving convergence stability, generation quality, and scalability for effective art design generation and analysis. Results: The results demonstrate that the GCR-SGAN model had accuracy of 0.98, which efficiently generates high-quality public art designs, optimizing both visual appeal and training stability. Conclusion: The approach effectively advances the generation of diverse, scalable art for real-world applications.conclusions: This research is to apply deep learning techniques to extract and analyze elements of public art in Suzhou Subway, exploring their cultural significance, design patterns, and potential applications in urban planning, enhancing the aesthetic and functional aspects of subway spaces.
CARACTERIZACIÓN QUÍMICA DE EXCRETAS DE CERDO SECAS Y MADURAS PROVENIENTES DE TRES NIVELES DE ENERGÍA
Authors: Morales Maldonado Emilio Raymundo , Trejo Lizama Wilberth , Santos Ricalde Ronald Herve , Bacab Perez Hector Manuel 
Published: February 2025

<p>The objective of this study was to determine the optimal conditions of the diet that will generate excreta of pigs with a chemical composition more suited to the needs of organic fertilizers. Twelve pigs were subjected to three levels of maintenance metabolizable energy (EMM): high (3.5 EMM), medium (2.5 EMM) and low (1.5 EMM). A portion of the excreta was collected composting to maturity. Factorial design was used and data were statistically analyzed using SAS version 9.0. The measured variables included feed and grass intake, manure production, total nitrogen, carbon, temperature, pH and C/ N ratio. The highest feed intake was corresponded to the high energy level (1.112 kg/d), while the low and medium energy levels had higher grass/forage intake values (0.103 and 0.095 kg/day). The high energy level recorded increased total dry matter (DM) consumption (1.197 kg/day), while the excreta production was higher in the low and medium energy levels (0.298 and 0.295 kg/day). During the 21 days of composting period, the high and medium energy levels recorded higher temperatures (60 °C) versus the low energy group (58 °C). Regarding the pH, no significant differences were detected. Among the tested energy levels, the low level showed highest C/N ratio (10.0:1). The mature excreta had higher C/N ratio (10.6:1) as compared to the dry excreta (8.1:1). </p>
EVALUATING THE GROWTH PERFORMANCE OF LOCAL KEI CHICKENS AND THEIR F1-CROSSES WITH RHODE ISLAND RED AND FAYOUMI BREEDS IN WATERSHED AREAS OF GURAGHE ADMINISTRATIVE ZONE, SOUTHERN ETHIOPIA
Authors: Alewi Misba , Melesse Aberra 
Published: February 2025

<p>This study describes the on-farm performance of local Kei chicken and its F<sub>1</sub> crosses with Fayoumi and Rhode Island Red (RIR) breeds in <em>Beresa</em> watershed of <em>Guraghe </em>administrative zone, southern Ethiopia. The Kei paternal line was mated with maternal lines of Fayoumi and RIR chickens to produce F<sub>1</sub>-crosses. Body weight developments and feed intake were determined on weekly basis. Then body weight gain and feed efficiency ratios (FER, weight gain: feed) were calculated. Hatchability was 59.0% and 73.7%, 54.7% for Kei, Fayoumi-crosses and RIR-crosses, respectively. In male chicks, the mean day-old weight ranged from 28.8 to 40.1 g and in female chicks from 26.2 to 35.8 g. The average body weight of matured male and female RIR-crosses was 1682 and 1227 g, respectively. The corresponding values for Fayoumi-crosses were 1310 and 1054 g and that of local Kei 1273 and 987 g. During the brooding period, the average daily feed intake was 25.9, 27.0 and 24.4 g for Kei, Fayoumi-crosses and RIR-crosses, respectively. The mean FER was 0.197, 0.213 and 0.243 g for Kei, Fayoumi-crosses and RIR-crosses, respectively. The average age at sexual maturity for Kei, Fayoumi-crosses and RIR-crosses was 183, 154 and 162 days, respectively. The results of the present study suggest that both F<sub>1</sub>-crosses showed a significant improvement in body weight, weight gain and FER under farmers’ management condition of the watershed areas suggesting the suitability of both genetic combinations with local Kei chickens for on-farm chicken productivity. </p>
DESIGN AND IMPLEMENTATION OF A COMMUNITY-BASED BREEDING PROGRAM FOR DAIRY GOATS IN NORTHERN MEXICO
Authors: Wurzinger Maria , Escareño Luis , Pastor Francisco , Salinas Homero , Iñiguez Luis , Sölkner Johann 
Published: February 2025

<p>This paper describes the research and development process for the design and implementation of a community-based breeding program for smallholders. The emphasis of the paper is on the organisation and practical procedures of the breeding program. The selection process of young breeding bucks based on own growth performance and on mother´s milk performance is described. The sustainability of a breeding program can only be ensured when there is a long-term commitment from researchers and extension service to collaborate with farmers and support them in the decision-making process. Ownership of farmers was created by handing-over many responsibilities and decision mechanisms to them and researchers played the role of facilitators. </p>
An assessment of Factors Affecting General Insurance Penetration in Lusaka District of Zambia
Authors: Mwale Stephen , Mwange Austine 
Published: February 2025

Background: Zambia's insurance industry faces challenges, as evidenced by low penetration rates and a 2019 report from the Insurance Association of Zambia. A 2020 Price Waterhouse Coopers survey highlighted issues such as premium debt recovery and a lack of understanding of insurance benefits among the population. This research aimed to investigate barriers to insurance awareness and uptake.
Methods: A mixed-method approach combined quantitative and qualitative elements to assess insurance penetration in Lusaka District. Guided by pragmatism, the study utilized simple random and purposive sampling, collecting data through structured questionnaires (n=33) and in-depth interviews (n=5). Quantitative analysis employed various statistical techniques, while qualitative data were analyzed through Thematic Framework Analysis.
Findings: Results indicated a high level of insurance awareness (mean score 3.9) with a significant association (p = 0.02) between awareness and uptake. Although insurance products were deemed suitable (mean score 3.9), no significant correlation with uptake was found (p = 0.67). Awareness and understanding were identified as key factors influencing insurance uptake, with an adjusted odds ratio of 3.7 (p = 0.04).
Conclusion: Awareness and understanding are critical drivers of insurance uptake in the Lusaka District. Recommendations include enhancing educational campaigns, simplifying insurance products, tailoring marketing strategies, and improving regulatory support. Limitations of the study include reliance on self-reported data. Future research should examine how digital literacy affects insurance uptake among diverse demographic groups.
Disciplinas del Derecho Humano de la Salud. Un caso en la legislación costarricense
Authors: Valerio Monge Carlos José 
Published: February 2025

Health jurists in the European Union have led the debate on these issues, as has been the case more recently with regard to the need to regulate artificial intelligence. For this reason, European studies on Health Law, particularly Spanish ones, are the most exemplary in approaching this issue and proposing its knowledge, debate and correct application.It must be made clear that there is no general consensus on this proposal, and it is common for some authors to defend slightly different positions. However, the legal theory formulated here is the one that has the greatest support due to its coherence from the point of doctrinal rigor. However, academic efforts such as this one attempt to provoke discussions with educational, reflective and debate-generating purposes towards the consolidation of a Costa Rican theory on these issues to become the subject of law classrooms, the development of regulations, the issuance of administrative and judicial resolutions and, more contributions published in books and journals of Costa Rican law.
Los juristas de la salud de la Unión Europea han conducido el debate de estos temas, como ha sido más recientemente respecto de la necesidad de regular la inteligencia artificial. Es por este motivo, que los estudios europeos del Derecho de la Salud, particularmente los españoles, resultan los más ejemplarizantes para acercarse a este tema y proponer su conocimiento, debate y aplicación correcta.Debe quedar claro que no existe un consenso general sobre esta propuesta, siendo común que algunos autores defienden posturas ligeramente distintas. Sin embargo, la teoría jurídica que aquí se formula es la que cuenta con el mayor respaldo debido a su coherencia desde el punto del rigor doctrinario. Empero, esfuerzos académicos como el presente intentan provocar discusiones con propósitos educativos, reflexivos y generadores de debate hacia la consolidación de una teoría costarricense sobre estos temas para constituirse en materia de las aulas de Derecho, la elaboración de normas, la emisión de resoluciones administrativas y judiciales y, más aportes publicados en libros y revistas del Derecho costarricense.
काव्यशास्त्रे रसतत्त्वविमर्शस्य महत्वम्
Authors: सुरभि घोष  
Published: February 2025

रसः काव्यस्य आत्मा इति मन्यते। रसः काव्यस्य अत्यावश्यकः तत्त्वः अस्ति यः जनानां हृदयेषु परमं आनन्दं जनयति। संस्कृतकाव्यशास्त्रे रसशब्दः रसः, आनन्दः, काव्यानुभवः, काव्य- परिणामादिः इति अर्थे गृह्यते। भरतः रसनिषपट्टिसूत्रं व्याख्याय विभावानुभवव्याभिचारिभवयोः संयोगेन रसः उत्पन्नः इति उक्तवान्। रससूत्रस्य मुख्यव्याख्यकाः चत्वारः आसन्, ये सन्धिफलं च व्याख्यायन्ते स्म।
Upaya Guru dalam Mengatasi Kesulitan Membaca Permulaan Pada Siswa Kelas 1 MI Islamiyah Taman-Sidoarjo
Authors: Nurul Nazilah Siti , Isma Nuriza Khusnul 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang mempengaruhi kesulitan membaca permulaan pada siswa dan bagaimana upaya guru dalam mengatasi kesulitan membaca permulaan pada siswa. Dalam penelitian ini menggunakan pendekataan kualitatif dan jenis penelitian ini mengunakan deskriptif. Subjek penelitian ini siswa kelas 1 MI Islamiyah Taman-Sidoarjo dengan jumlah 38 siswa dengan pengumpulan data yaitu berupa observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukan bahwa faktor-faktor yang mempengaruhi kesulitan membaca permulaan kelas 1 MI Islamiyah Taman-Sidoarjo ialah: Kurangnya perhatian dari orang tua, seringnya lupa huruf, lingkungan dari teman, kurangnya percaya diri, sulit mengeja. Selain itu dari hasil penelitian ini menunjukan bahwa upaya guru dalam mengatasi kesulitan membaca permulaan kelas 1 MI Islamiyah Taman-Sidoarjo yaitu sebagai berikut: Mengunakan metode suku kata, ketika jam pelajaran berlangsung guru memperhatikan dan mengarahkan, memberikan motivasi, meminjamkan buku di perpustakaan, memeberikan jam tambahan. Maka dapat disimpulkan bahwa upaya guru dalam mengatasi kesulitan membaca siswa sangat berpengaruh pada siswa yang berkesulitan membaca permulaan.