bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Innovative Academic/Practice Partnership to Support Nursing Workforce Needs and Student Clinical Education
Authors: Hahn Judith , Resha Cheryl-Ann , Beauvais Audrey , Beckman Beth , Forte Pamela , Rebeschi Lisa M. , Snyder Marianne 
Published: January 2023

ABSTRACT
Innovation is needed to solve nursing workforce issues during times of crisis. A collaborative effort between a hospital system and several universities resulted in the Bridge to Professional Practice Program that was implemented during a period of high patient volume and nursing student downtime. The program provided support for staffing needs and clinical hours to promote readiness for practice for students. The program evaluation outcomes and recommendations for improvement are addressed.
Gene Expression Profiles in Cancers and Their Therapeutic Implications
Authors: Creighton Chad J. 
Published: January 2023

Abstract
The vast amount of gene expression profiling data of bulk tumors and cell lines available in the public domain represents a tremendous resource. For any major cancer type, expression data can identify molecular subtypes, predict patient outcome, identify markers of therapeutic response, determine the functional consequences of somatic mutation, and elucidate the biology of metastatic and advanced cancers. This review provides a broad overview of gene expression profiling in cancer (which may include transcriptome and proteome levels) and the types of findings made using these data. This review also provides specific examples of accessing public cancer gene expression data sets and generating unique views of the data and the resulting genes of interest. These examples involve pan-cancer molecular subtyping, metabolism-associated expression correlates of patient survival involving multiple cancer types, and gene expression correlates of chemotherapy response in breast tumors.
A Brief Overview of Cancer Vaccines
Authors: Muller Alexander J. , Thomas Sunil , Prendergast George C. 
Published: January 2023

Abstract
Vaccine strategies for cancer differ from infectious disease in focusing mainly on clearing rather than preventing disease. Here we survey general vaccine strategies and combination therapy concepts being investigated for cancer treatment, with a focus on tumor antigens rather than cancer-inducing viruses or microorganisms. Many tumor antigens are “altered-self” and tend to arouse weaker immune responses than “foreign” antigens expressed by infectious agents. Further, unlike an infectious disease patient, a cancer patient's immune system is damaged, suppressed, or senescent and mainly tolerant of their disease. Thus, vaccine efficacy in a cancer patient will rely upon adjuvant or combination treatments that correct the inflammatory tumor microenvironment and degrade tumoral immunosuppression that dominates patient immunity. This brief overview is aimed at new researchers in cancer immunology seeking an overview of vaccine concepts to eradicate malignancy by provoking a selective immune attack.
Impact of Precision Medicine in Oncology
Authors: Buchbinder Elizabeth I. , Hodi F. Stephen 
Published: January 2023

Abstract
Cancer treatment has dramatically changed over the last decade with the development of immunotherapy. Therapies including immune cytokines, immune checkpoint inhibition, intratumoral therapies, and cellular therapies are already widely used in the oncology clinic. Active development continues in these areas and in the development of vaccines, bispecific therapies, and more refined cellular therapies. In this review, we will examine the role that immune therapy has in cancer treatment and explore areas of future development.
Facial Fractures in Indigenous and Non-indigenous Populations of South Australia
Authors: Diab Jason , Flapper Walter J. , Moore Mark H. 
Published: January 2023

Introduction:
Maxillofacial trauma in indigenous populations is complex with sociocultural factors, access to health care, and poorer general health issues that impact outcomes. Assaults and road traffic accidents are disproportionately experienced by indigenous persons compared with non-indigenous.

Methods:
A retrospective review was conducted from January 2012 to January 2017 at the Women and Children’s Hospital and Royal Adelaide Hospital, Adelaide. All maxillofacial fractures that attended or were referred to the unit were included in this study. The primary objective was to analyze epidemiological trends of facial fractures and clinical outcomes in the South Australian indigenous and non-indigenous populations.

Results:
Maxillofacial fractures in indigenous persons were less than in non-indigenous (31.2 versus 38.2 y, P < 0.001) with 3.8 odds of a facial fracture. Assault was 2.9 times more likely to result in a facial fracture, falls 40.9% less likely, and sports 29.4% less likely compared with non-indigenous (P < 0.001). Alcohol-related facial fractures had significantly higher rates [odds ratio (OR = 3.8)] compared with non-indigenous. Indigenous from most disadvantaged areas and very remote areas also had significantly higher odds of a facial fracture. Indigenous persons had higher operative rates (OR = 2.8), postoperative complications (OR = 3.1), and a 3.7-day mean difference for the length of stay (6.6 versus 2.9 d, P < 0.001).

Conclusions:
Indigenous people are more likely to experience facial fractures from assault resulting in mandibular fractures, whereas non-indigenous people are likely to have sport or fall-related midface fractures. Young indigenous women from outer regional and very remote areas have greater odds of facial fractures caused by assault and alcohol with higher operative rates, postoperative complications, and extended length of stay.
The High Incidence of Occult Carcinoma in Total Hepatectomy Specimens of Patients Treated for Unresectable Colorectal Liver Metastases With Liver Transplant
Authors: Chávez-Villa Mariana , Ruffolo Luis I. , Al-Judaibi Bandar M. , Fujiki Masato , Hashimoto Koji , Kallas Jeffrey , Kwon Choon Hyuck David , Nair Amit , Orloff Mark S. , Pineda-Solis Karen , Raj Roma , Sasaki Kazunari , Tomiyama Koji , Aucejo Federico , Hernandez-Alejandro Roberto 
Published: January 2023

Objective:
To describe the rate of occult carcinoma deposits in total hepatectomy specimens from patients treated with liver transplant (LT) for colorectal liver metastases (CRLM).

Background:
Previous studies have shown that patients with CRLM treated with systemic therapy demonstrate a high rate of complete radiographic response or may have disappearing liver metastases. However, this does not necessarily translate into a complete pathologic response, and residual invasive cancer may be found in up to 80% of the disappearing tumors after resection.

Methods:
Retrospective review of 14 patients who underwent LT for CRLM, at 2 centers. Radiographic and pathologic correlation of the number of tumors and their viability before and after LT was performed.

Results:
The median (interquartile range) number of tumors at diagnosis was 11 (4–23). The median number of chemotherapy cycles was 24 (16–37). Hepatic artery infusion was used in 5 patients (35.7%); 6 (42.9%) underwent surgical resection, and 5 (35.7%) received locoregional therapy. The indication for LT was unresectability in 8 patients (57.1%) and liver failure secondary to oncologic treatment in the remaining 6 (42.9%). Before LT, 7 patients (50%) demonstrated fluorodeoxyglucose-avid tumors and 7 (50%) had a complete radiographic response. Histopathologically, 11 patients (78.6%) had a viable tumor. Nine (64.2%) of the 14 patients were found to have undiagnosed metastases on explant pathology, with at least 22 unaccounted viable tumors before LT. Furthermore, 4 (57.1%) of the 7 patients who demonstrated complete radiographic response harbored viable carcinoma on explant pathology.

Conclusions:
A complete radiographic response does not reliably predict a complete pathologic response. In patients with unresectable CRLM, total hepatectomy and LT represent a promising treatment options to prevent indolent disease progression from disappearing CRLM.
Adverse Events and Morbidity in a Multidisciplinary Pediatric Robotic Surgery Program. A prospective, Observational Study
Authors: Vinit Nicolas , Vatta Fabrizio , Broch Aline , Hidalgo Mary , Kohaut Jules , Querciagrossa Stefania , Couloigner Vincent , Khen-Dunlop Naziha , Botto Nathalie , Capito Carmen , Sarnacki Sabine , Blanc Thomas 
Published: January 2023

Objective:
To report one-year morbidity of robotic-assisted laparoscopic surgery (RALS) in a dedicated, multidisciplinary, pediatric robotic surgery program. Summary Background Data. RALS in pediatric surgery is expanding, but data on morbidity in children is limited.

Methods:
All children who underwent RALS (Da Vinci Xi, Intuitive Surgical, USA) were prospectively included (October 2016 to May 2020; follow-up ≥1 year). Analyzed data: patient characteristics, surgical indication/procedure, intraoperative adverse events (ClassIntra classification), blood transfusion, hospital stay, postoperative complications (Clavien-Dindo).

Results:
Three hundred consecutive surgeries were included: urology/gynecology (n=105), digestive surgery (n=83), oncology (n=66), ENT surgery (n=28), thoracic surgery (n=18). Median age and weight at surgery were 9.5 [interquartile range (IQR)=8.8] years and 31 [IQR=29.3] kg, respectively. Over one year, 65 (22%) children presented with ≥1 complication, with Clavien-Dindo ≥III in 14/300 (5%) children at ≤30 days, 7/300 (2%) at 30-90 days, and 12/300 (4%) at >90 days. Perioperative transfusion was necessary in 15 (5%) children, mostly oncological (n=8). Eight (3%) robotic malfunctions were noted, one leading to conversion (laparotomy). Overall conversion rate was 4%. ASA ≥3, weight ≤15 kg, and surgical oncology did not significantly increase the conversion rate, complications, or intraoperative adverse events (ClassIntra ≥2). ASA score was significantly higher in children with complications (Clavien-Dindo ≥III) than without (p=0.01). Median hospital stay was 2 [IQR=3] days. Three children died after a median follow-up of 20 [IQR=16] months.

Conclusions:
RALS is safe, even in the most vulnerable children with a wide scope of indications, age, and weight. Robot-specific complications or malfunctions are scarce.
COVID-19 isolation and quarantine orders in Berlin-Reinickendorf (Germany): How many, how long and to whom?
Authors: Schumacher Jakob , Kühne Lisa , Brüssermann Sophia , Geisler Benjamin , Jäckle Sonja 
Published: January 2023

AbstractIsolating COVID-19 cases and quarantining their close contacts can prevent COVID-19 transmissions but also inflict harm. We analysed isolation and quarantine orders by the local public health agency in Berlin-Reinickendorf (Germany) and their dependence on the recommendations by the Robert Koch Institute, the national public health institute. Between 3 March 2020 and 18 December 2021 the local public health agency ordered 24603 isolations and 45014 quarantines (mean contacts per case 1.9). More days of quarantine per 100 inhabitants were ordered for children than for adults: 4.1 for children aged 0-6, 5.2 for children aged 7-17, 0.9 for adults aged 18-64 and 0.3 for elderly aged 65-110. The mean duration for isolation orders was 10.2 and for quarantine orders 8.2 days. We calculated a delay of 4 days between contact and quarantine order. 3484 of contact persons were in quarantine when they developed an infection. Our study quantifies isolation and quarantine orders, shows that children had been ordered to quarantine more than adults and that there were fewer school days lost to isolation or quarantine as compared to school closures. Our results indicate that the recommendations of the Robert Koch Institute had an influence on isolation and quarantine duration as well as contact identification and that the local public health agency was not able to provide rigorous contact tracing, as the mean number of contacts was lower than expected.
Blood flow restriction resistance training as an alternative to resistance training alone to improve strength in elderly: a systematic review with meta-analysis
Authors: Silveira Mallmann André Luiz , dos Santos Leonardo Peterson , Doria Lucas Denardi , Ferreira Luis Fernando , Ramis Thiago Rozales , da Rosa Luís Henrique Telles 
Published: January 2023

ABSTRACTThe purpose of this research was to perform a systematic review with meta-analysis to compare the effects of resistance training with blood flow restriction (BFR) to the effects of non-training (CON) and traditional RT on strength in elderly people. This was a systematic review with meta-analysis of randomized clinical trials (RCTs), published in English, from inception to 2022, conducted using MEDLINE (PubMed), EMBASE, Web of Science and Cochrane Library. The methodological quality was assessed using GRADE protocol. The risk of bias was assessed using RoB2 software. Standardized mean differences (SMD), mean difference, were pooled using a random-effects model. A p < 0.05 was considered statistically significant. Eight RCT’s were included. We found no significant differences in the effects between BFR and RT (SMD = -0.18 [-0.56 to 0.19]; p = 0.34; I2= 12%). Also, evidence from our research shows that the effect of BFR is better than non-training (CON) for strengthening in older adults (SMD = 0.63 [0.24 to 1.01]; p = 0.001; I2= 11%). Our primary findings show that training with BFR may be an alternative methodology of training for the elderly and this training strategy may be interesting for health professionals working with elderly people with low tolerance to high intensity RT.
Is lifestyle coaching a potential cost-effective intervention to address the backlog for mental health counselling? A Rapid Review
Authors: Makanjuola Abraham , Granger Rachel , Pisavadia Kalpa , Edwards Rhiannon Tudor 
Published: January 2023

AbstractAimThe aim of this rapid review was to investigate whether lifestyle coaching could provide a cost-effective alternative to counselling for the UK National Health Service (NHS) treatment of common mental health conditions such as stress, anxiety and depression.MethodsA rapid review approach was used to determine the evidence of health economics evaluations in the field of mental health services. A literature search of PubMed, CINAHL, Cochrane Library, ASSIA, PsycINFO and MEDLINE produced 2807 articles. We removed 778 duplicates, and 2029 study articles remained. Two reviewers screened titles and abstracts (RG and KP), and 37 papers met the inclusion criteria of this review. Following a full-text screening, a further 27 papers were excluded due to lack of relevance. Study designs which did not include economic evaluations (n=15) or did not include an evaluation treatment of mental health conditions with talking therapies (n=15) did not meet the inclusion criteria. Ten papers were included in the final rapid review.ResultsThe database search yielded study articles which focused on the cost-effectiveness of counselling and other talking therapies such as Cognitive Behavioural Therapy (CBT). No literature was found to determine the cost-effectiveness, or effectiveness of lifestyle coaching. Due to a lack of economic evaluations, this review could not determine the potential cost-effectiveness of lifestyle coaching as a means of addressing the backlog for mental health support such as counselling in the NHS.ConclusionThis review highlights the research gap in assessing the cost-effectiveness of lifestyle coaching for treating common mental health disorders. The proposed next step is to evaluate the effectiveness and cost-effectiveness of lifestyle coaching versus current treatment as usual (counselling) by using a feasibility randomised control trial.Paper typeA rapid reviewArticle summaryStrengths and limitations of this studyThis rapid review found a range of different economic evaluations of mental health interventions for common mental health issues.All of the study articles found were moderate to high quality, some of the included study articles met all of the checklist criteria.This rapid review found no evidence from a UK study setting. However, all study articles came from OECD countries that share similar legal structures and policies with comparable populations.Despite being mentioned in a number of studies, it is unclear what treatment as usual refers to, and is perhaps not as usual as the studies suggest.
Systematic Review Association between Endotype of Prematurity and Mortality: A Systematic Review, Meta-analysis and Meta-regression
Authors: Hundscheid Tamara M , Villamor-Martinez Eduardo , Villamor Eduardo 
Published: January 2023

AbstractIntroductionPreterm birth represents the leading cause of neonatal mortality. Pathophysiological pathways, or endotypes, leading to prematurity can be clustered into infection/inflammation and dysfunctional placentation. We aimed to perform a systematic review and meta-analysis exploring the association between these endotypes and risk of mortality during first hospital admission.MethodsPROSPERO ID: CRD42020184843. PubMed and Embase were searched for observational studies examining infants with gestational age (GA) ≤34 weeks. Chorioamnionitis represented the infectious-inflammatory endotype, while dysfunctional placentation proxies were hypertensive disorders of pregnancy (HDP) and small for GA (SGA)/intrauterine growth restriction (IUGR). A random-effects model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Heterogeneity was studied using random-effects meta-regression analysis.ResultsOf 4322 potentially relevant studies, 150 (612,580 infants) were included. Meta-analysis showed a positive mortality odds for chorioamnionitis (OR 1.43, 95% CI 1.25-1.62) and SGA/IUGR (OR 1.68, 95% CI 1.38-2.04), but a negative mortality odds for HDP (OR 0.74, 95% CI 0.64-0.86). Chorioamnionitis was associated with a lower GA, while HDP and SGA/IUGR were associated with a higher GA. Meta-regression showed a significant correlation between these differences in GA and mortality odds.Discussion/ConclusionOur data suggest that the infectious/inflammatory endotype of prematurity has a greater overall impact on mortality risk as it is the most frequent endotype in the lower GAs. However, when the endotype of placental dysfunction is severe enough to induce growth restriction, it is strongly associated with higher mortality rates even though newborns are more mature.
Comparison of outcomes of Long versus Short Cephalomedullary nails for the fixation of intertrochanteric femur fractures: A Protocol for Systematic Review and Meta-analysis
Authors: Rajnish Rajesh Kumar , Srivastava Amit , Kumar Prasoon , Yadav Sandeep Kumar , Sharma Siddhartha , Haq Rehan Ul , Aggarwal Aditya Nath 
Published: January 2023

AbstractBackgroundThe incidence of intertrochanteric femur fracture (IFF) in the elderly has increased with increased life expectancy globally. These fractures require surgeries at the earliest to bring them out of bed and minimize the complications of recumbency, like decubitus ulcers, decreased cardiopulmonary reserves, and thromboembolic events. Dynamic hip screws and Cephalomedullary nails (CMN) are both considered adequate for the internal fixation of the stable IFF with comparable stability and outcomes. However, CMNs are considered to have better results in unstable IFF fixation.ObjectiveTo compare the outcomes of internal fixation of short CMN versus long CMN of IFF in the elderly by analyzing the evidence from the current literature.MethodsA systematic review and meta-analysis will be performed in accordance with the PRISMA guidelines. A primary search of Medline, Embase, Scopus, and Cochrane Library databases will be conducted using a pre-defined search strategy. The studies of any design in the English language will be included, which have compared the outcomes of the internal fixation of short CMN versus long CMN of the IFF and reported at least one primary or secondary outcome of interest.Studies that did not compare the outcomes of the internal fixation of short CMN versus long CMN of the IFF, conference abstracts, posters, case reports, book chapters, technical tips, review articles, biomechanical studies, cadaveric studies, and the articles not in the English language will be excluded.Both qualitative and quantitative analyses will be performed. A qualitative analysis will be performed using appropriate tables and diagrams. Wherever feasible, quantitative analysis will be done with the appropriate software. The risk-of-bias assessment for non-randomized comparative studies will be done using the MINORS tool, and the Cochrane Collaboration’s risk-of-bias tool will be used for randomized control trials (RCT).
A scoping review on the associations and potential pathways between malnutrition and measles
Authors: Tran Isabelle CT , Gregory Christopher , O’Connor Patrick , Imohe Annette , Do Lien Anh Ha , Suchdev Parminder S 
Published: January 2023

AbstractAmid a measles resurgence worldwide, many affected regions also find themselves in circumstances of conflict, humanitarian or political crises, climate extremes, ongoing pandemic challenges, income inequality and economic downturns. Those contextual factors have driven increases in worldwide undernourishment over the past year. The overlap and frequent occurrence of those socio-structural determinants in fragile geographies is worrying as a synergistic relationship between measles and malnutrition has been reported. A scoping review was conducted to map current evidence and identify research gaps on the association between malnutrition and measles.Sixty-seven studies were retained following a search of multiple databases, snowballing and consultations with experts. Studies reported on a measure of association, a relationship, or potential mechanisms behind the link between malnutrition and measles.Overall, there was evidence of a positive correlation between undernutrition and reported measles incidence and mortality. All studies reviewed found an association between vitamin A deficiency and increased likelihood of incident measles, measles-related complications and measles-related deaths. Available evidence also suggested that therapeutic vitamin A can significantly reduce the odds of measles-related mortality, and preventative vitamin A can reduce reported measles incidence. Little data shed light on potential pathways behind malnutrition and measles. Inconsistent variable definitions (i.e. malnutrition and measles cases) across studies precluded calculating a cumulative effect size, and findings may be impacted by uncontrolled confounding factors.This scoping review reinforces the hypothesis of a synergistic relationship between measles and malnutrition and highlights the need for an integrated approach to the delivery of malnutrition interventions and measles prevention and control. In addition, further robust studies are needed to better define pathophysiological targets for interventions and allow for stronger inferences to policy making. Future research should also consider using a standardized approach to defining malnutrition and measles to ensure comparability of outcomes across studies.