bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Novel Fluoro Phenyl Triazoles Via Click Chemistry with or
without Microwave Irradiation and their Evaluation as Anti-proliferative
Agents in SiHa Cells
Authors: Aguilar Johana , Leyva Elisa , Loredo-Carrillo Silvia Elena , Cárdenas-Chaparro Agobardo , Martínez-Richa Antonio , Hernández-López Hiram , Araujo-Huitrado Jorge Gustavo , Granados-López Angélica Judith , López-Hernández Yamilé , Adrián López Jesús 
Published: April 2023

Aims:
Perform the synthesis of novel fluoro phenyl triazoles via click chemistry with or without microwave irradiation and their evaluation as anti-proliferative agents in SiHa cells

Background:
Triazoles are heterocyclic compounds containing a five-member ring with two carbon and three nitrogen atoms. They are of great importance since many of them have shown to have biological activity as antifungal, antiviral, antibacterial, anti-HIV, anti-tuberculosis, vas-odilator, and anticancer agents.

Objective:
Synthesize novel fluoro phenyl triazoles via click chemistry and evaluate their anti-proliferative activity

Methods:
First, several fluorophenyl azides were prepared. Reacting these aryl azides with phe-nylacetylene in the presence of Cu(I) catalyst, the corresponding fluoro phenyl triazoles were ob-tained by two methodologies, stirring at room temperature and under microwave irradiation at 40 ºC. In addition, their antiproliferative activity was evaluated in cervical cancer SiHa cells

Results:
Fluoro phenyl triazoles were obtained within minutes by means of microwave irradia-tion. The compound 3f, containing two fluorine atoms next to the carbon connected to the tria-zole ring, was the most potent among the fluoro phenyl triazoles tested in this study. Interesting-ly, the addition of a fluorine atom to the phenyl triazole structure in a specific site increases its antiproliferative effect as compared to parent phenyl triazole 3a without a fluorine atom.

Conclusion:
Several fluoro phenyl triazoles were obtained by reacting fluoro phenyl azides with phenylacetylene in the presence of copper sulphate, sodium ascorbate and phenanthroline. Prepa-ration of these triazoles with MW irradiation represents a better methodology since they are ob-tained within minutes and higher yields of cleaner compounds are obtained. In terms of biological studies, the proximity between fluorine atom and triazole ring increases its biological activity.
Is a Genetic Variant associated with Bipolar Disorder Frequent in People without Bipolar Disorder but with Characteristics of Hyperactivity and Novelty Seeking?
Authors: Kalcev Goce , Scano Alessandra , Orrù Germano , Primavera Diego , Cossu Giulia , Nardi Antonio Egidio , Carta Mauro Giovanni 
Published: April 2023

Objective:
The objective is to verify whether a genetic condition associated with bipolar disorder (BD) is frequent in old adults adapted to their environment, without BD, but with aptitudes for hyperactivity and novelty seeking (H/NS).

Methods:
In this cross-sectional study, the study sample included healthy elderly people (40 participants, aged 60 or older) living in an urban area and recruited from a previous study on physical exercise and active aging, who were compared with 21 old adults with BD from the same area. The genetic methodology consisted of blood sampling, DNA extraction, real-time PCR jointly with FRET probes, and the SANGER sequencing method. The genetic variant RS1006737 of CACNA1C, found to be associated with bipolar disorder diagnosis, was investigated.

Results:
The frequency of the RS1006737 genetic variant in the study group (H/NS) is not higher than in the BD group and is statistically significantly higher than in all the control groups found in the literature. However, the familiarity for BD is higher in old adults with BD than in the H/NS sample without BD. The risk of BD in the family (also considering those without BD but with family members with BD) is not associated with the presence of the genetic variant examined.

Conclusion:
The study suggests that the gene examined is associated with characteristics of hyperactivity rather than just BD. Nevertheless, choosing to participate in an exercise program is an excessively general way to identify H/NS. The next step would be to identify the old adults with well-defined H/NS features with an adequate tool.
Differential Diagnosis Models for Multiple Myeloma Combined with Renal Injury and Chronic Kidney Disease or Nephrotic Syndrome
Authors: Wu Mei-Na , Yang Yong-Li , Tan Jie-Bing , Jia Xiao-Can , Bao Jun-Zhe , Wang Yu-Ping , Yang Chao-Jun , Shi Xue-Zhong 
Published: April 2023

Background:
When multiple myeloma(MM) is combined with renal injury, most patients are easily misdiagnosed as kidney diseases. This study aimed to establish a differential diagnosis model for MM combined with renal injury based on clinical information.

Methods:
A total of 77 patients with MM combined with renal injury were recruited as the case group, and 112 patients with kidney diseases were recruited as a control group. Support vector machine (SVM), decision tree (DT), and artificial neural network (ANN) models were developed based on significant clinical variables. Accuracy and area under the receiver operating characteristic curve (AUC) were used to evaluate each model.

Results:
Accuracies of SVM, DT, and ANN were 0.843,0.902, and 0.941. The AUCs of SVM, DT, and ANN were 0.822,0.879, and 0.932. Lower extremity edema, bone pain, and lactate dehydrogenase (LDH) were common important indicators identified by SVM, DT and ANN models. When these three indicators were excluded, the ANN model prediction effect decreased significantly (P<0.05).

Conclusion:
The results suggest that the ANN model best predicts the differential diagnosis between MM combined with renal injury and chronic kidney disease/nephrotic syndrome. Important features contributing to identifying the diseases, including lower extremity edema, bone pain, and LDH, may assist in diagnosing such diseases in the future.
Experimental Investigation of Ultimate Shear Force Capacity of Glulam Reinforced with Glued-in Threaded Rods
Authors: Bahrami Alireza , Blomberg Emil , Boqvist Simon , Lauridsen Markus , Eriksson Bengt 
Published: April 2023

Background:
Glued-in threaded (GIT) rods have been considered an effective timber connection method having several advantages, such as high load-carrying capacity, great stiffness, and good fire resistance. This type of connection has widely been utilized in newly built modern timber structures and for reinforcing the existing ones.

Objective:
The purpose of this experimental research is to investigate how the ultimate shear force capacity (USFC) of glulam is affected if it is reinforced with GIT rods and to study the interaction between the glulam and GIT rods. The results of this research can help researchers and engineers to select a suitable method of reinforcing the glulam with GIT rods at a superior inclination angle (IA) to the fiber direction in order to achieve higher USFCs.

Methods and Experimental Tests:
A total of forty glulam samples were tested for failure. The experimental tests consisted of five different series of samples with eight samples in each series. Sample series 1 were unreinforced glulam. Sample series 2 and 4 were glulam reinforced with the GIT rods at two different IAs of 45° and 90° to the fiber direction, respectively. Sample series 3 and 5 were glulam reinforced in the same way as sample series 2 and 4, but they were split in the middle. The samples were tested for failure using a standard testing machine. The machine was connected to a computer that recorded all the values obtained from the tests.

Results:
The results of the study were obtained as force-displacement graphs. The stiffness of the samples and interaction between the glulam and GIT rods were also calculated. The results achieved from the experimental tests of different series were compared and discussed.

Conclusion:
The experimental tests resulted in a 12.5% increase in the average USFC of sample series 2. However, the average USFC of sample series 4 was not enhanced significantly. The interaction between the glulam and GIT rods was obtained as 31.8% for the samples with reinforcing at the IA of 45° to the fiber direction and 3.8% for the samples with reinforcing at the IA of 90° to the fiber direction. Reinforcing the glulam with the GIT rods demonstrated the potential of enhancing its USFC. However, reinforcing the glulam with the GIT rods at the IA of 45° to the fiber direction was found to be superior to reinforcing the glulam with the GIT rods at the IA of 90° to the fiber direction.
Embarquer pour l’Inde, un motif narratif chez Xénophon d’Éphèse, Lucien et Philostrate
Authors: Robiano Patrick 
Published: April 2023

Paradoxically, at a time when trade between the Mediterranean and India was developing across the Indian Ocean, Greek fiction literature did not mirror it, with the exception of Xenophon of Ephesus, Lucian, and Philostratus, in the form, nevertheless, of very rare micro-narratives. It is therefore a question, in this article, of analyzing the reasons for the crossing to India and of hightlighting its stakes, in particular the representation that Greek-speaking writers give of the actors of these exchanges : Greeks, the so-called Egyptians, and Indians. It is also a question of understanding why these new routes to India did not create an imaginary that fiction could have exploited. Paradoxalement, à une époque où le commerce entre la Méditerranée et l’Inde se développait à travers l’océan Indien, la littérature grecque de fiction n’en rendait pas compte, à l’exception de Xénophon d’Éphèse, de Lucien et de Philostrate, sous la forme, néanmoins, de très rares micro-récits. Il s’agit donc, dans cet article, d’analyser les raisons de la traversée vers l’Inde et de mettre en valeur ses enjeux, en particulier la représentation que des écrivains de langue grecque donnent des acteurs de ces échanges : les Grecs, les prétendus Égyptiens et les Indiens. Il s’agit aussi de comprendre pourquoi ces nouvelles routes vers l’Inde n’ont pas créé un imaginaire que la fiction aurait pu exploiter.
Black Health in Canada: Protocol for a Scoping Review
Authors: Olanlesi-Aliu Adedoyin , Alaazi Dominic , Salami Bukola 
Published: April 2023

Background
Black Canadians experience poor health care, poor health outcomes, and a greater burden of health inequalities, much of which is rooted in the unequal distribution of social determinants of health. Despite Canada’s emphasis on social inclusion, Canada’s Black population faces substantial social inequities that affect their health and well-being. These disparities may specifically be attributed to racial discrimination, immigration status, precarious housing, underemployment, and increased poverty among Black Canadians.

Objective
This paper describes a protocol for a scoping review that aims to understand the range and nature of research conducted on the health of Black Canadians as well as the gaps in this literature.

Methods
Arksey and O'Malley’s methodological framework guided the conduct of the scoping review. We searched electronic databases (CINAHL, Embase, Global Health, MEDLINE, PsycINFO, Scopus, Sociological Abstracts, and Web of Science) and grey literature sources for peer-reviewed articles and grey reports on the health of Black Canadians. Six reviewers independently screened the abstracts and full text of studies to determine eligibility for inclusion. According to the PRISMA-ScR (Preferred Reporting Items for Systematics Reviews and Meta-Analyses extension for Scoping Reviews) guidelines, the findings will be synthesized quantitatively and qualitatively through thematic analysis.

Results
Title, abstract, and full-text screening concluded in October 2022. Data collection is in progress and is expected to be completed by April 2023. Data analysis and drafting of the manuscript will be done thereafter. Findings from the scoping review are expected to be provided for peer review in 2023.

Conclusions
This review will collect important data and evidence related to the health (mental, reproductive, and sexual; social determinants of health) of the Black population in Canada. The findings could help identify existing gaps in the health of Black individuals in Canada and inform future research paradigms. The findings will further inform the development of a knowledge hub on Black Canadians’ health.

International Registered Report Identifier (IRRID)
PRR1-10.2196/42212
Effectivity of Entomopathogen Fungus Metarhizium anisopliae (Metchnikoff) Sorokin to Mortality of Aedes aegypti Linnaeus, 1762 Larvae
Authors: Novitasari Amanda 
Published: April 2023

The Aedes aegypti mosquito is the vector that causes the spread of the Dengue virus that causes Dengue Hemorrhagic Fever. Breaking the chain of spread of Dengue fever has been done a lot, but it can cause negative impacts to environment. It is necessary to use other alternative solutions. One of them uses natural bioinsecticides from entomopathogenic fungi. The entomopathogenic fungus that has been widely developed as a bioinsecticide is Metarhizium anisopliae. Metarhizium anisopliae is a fungus which has larvicidal activity. Isolates of Metarhizium anisopliae were obtained from the Center for Forecasting Plant Pest Organisms, Karawang, West Java and Aedes aegypti larvae were obtained from Parasitology Laboratory, Faculty of Medicine, Public Health, and Nursing, UGM. The research was conducted from November 2021-April 2022 at the Entomology Laboratory, Faculty of Biology and the Parasitology Laboratory, Faculty of Medicine, Public Health, and Nursing, UGM, Yogyakarta. The method in this research is the culture and manufacture of a suspension of the fungus Metarhizium anisopliae with an average conidia density 0,9 x 107, 0,57 x 106, 1,175 x 105, 5,25 x 104, 3 x 104, 12,5 x 103 of conidia/mL, rearing of Aedes aegypti, bioassay, and data analysis using Probit Test with SPSS software version 23 to determine LC50. The effective concentration to kill 50% of larvae was 0.9 x 107 conidia/ml. There was no significant effect between each different concentration in killing Aedes aegypti larvae. The LC50 value obtained was 1.4 x 107. Metarhizium anisopliae was effectively to control Aedes aegypti larvae.
Стоянка-мастерская Кряж II — новый памятник эпохи камня в лесостепном Поволжье
Authors:   Samara State University of Social Sciences and Education (65/67, Gorky St., 443099 Samara, Russian Federation), Andreev Konstantin M. , Andreeva Olga V. , Aleshinskaya Anna S. , Kulkova Marianna A. , Vasiljeva Irina N. ,   Institute of Archaeology of the RAS (19, Dm. Ulyanov St., 117292 Moscow, Russian Federation),   Herzen University (48/12, Moyka Emb., 191186 St. Petersburg, Russian Federation),   Samara Archaeological Society (127, Leninskaya St., 443099 Samara, Russian Federation)
Published: April 2023

Introduction. The article outlines the results of excavations at Kryazh II workshop site located in the forest-steppe Volga region. The site is unique and contains an impressive collection of flint products and manufacturing wastes. Goals. The work aims to introduce materials from the excavations of 2017–2019 into scientific circulation. To facilitate this, the study shall describe and characterize the archaeological complexes, determine their cultural and chronological affiliations, and clarify the natural and climatic contexts to have witnessed the formation of the occupation layer. Materials. During three field seasons (2017–2019), an area of 192 m2 was studied. The total collection of artifacts numbers 5,989, of which ca. 250 items are ceramics and over 5,700 items are flint products — flakes and tools estimated at 6 % and less than 1.5 %, respectively. The majority of the finds over the entire area of the excavation lay in a thin layer (15–20 cm) of dark brown loam and in the upper part of brown loam. The performed palynological analysis makes it possible to identify three spore-pollen spectra in the section of the occupation layer. The paper also reveals six radiocarbon dates marking the time when the site was active. Results. The uniqueness of the flint complex at Kryazh II is determined by an increased concentration of flint artifacts per square meter of the studied area, an absolute predominance of manufacturing wastes, and a high percentage of products with indurated nodules, which makes it possible to interpret the site as a workshop. From a typological point of view, most of the ceramic items and flint inventory reveal similarities with materials of the Middle Volga culture from the Late Neolithic. At the same time, individual flint items and several fragments of ceramics are close enough to Eneolithic antiquities of the region in a number of aspects. The formation period of the site’s occupation layer dates to the mid-6th – mid-5th millennia BC characterized by the existence of forest-steppe landscapes close to modern ones. Conclusions. The study of Kryazh II workshop site has provided a collection of stone products — unique for the forest-steppe Volga region and dating mainly to the Late Neolithic era.
POLITICAL MYSTICISM AND THE LEGIONARY MOVEMENT IN INTERWAR ROMANIA. A COGNITIVE APPROACH
Authors: SONEA Ioana-Silvia 
Published: April 2023

Political Mysticism and the Legionary Movement in Interwar Romania. A Cognitive Approach. The purpose of this article is to explore the public discourse of the Iron Guard, the often called “exotic” Romanian fascist movement. I will focus especially on the messianic figure of Corneliu Zelea Codreanu, the charismatic leader of the movement, and the long lasting fascination he has exerted in the Romanian public space for more than a century now. The approach taken here is based on Gilles Fauconnier’s and Mark Turner’s conceptual integration theory and it is an attempt to show how by blending various mental spaces, from religious elements to medieval historical characters and events, the movement managed to create a unique mix that seemed to set it apart from other European fascist movements. Its members were extremely young and, by all accounts, genuinely religious, even practicing a type of political „mysticism” that was rather uncommon elsewhere.
Misticism politic și mișcarea legionară în România interbelică. O abordare cognitivă. Articolul de față propune o incursiune în discursul public al Legiunii Arhanghelului Mihail, „exotica” mișcare fascistă românească din perioada interbelică. Ne vom concentra mai ales pe figura mesianică a lui Corneliu Zelea Codreanu, liderul carismatic al mișcării și pe fascinația pe care a exercitat-o și continuă s-o exercite în spațiul public românesc. Abordarea pe care o propunem pornește de la teoria integrării conceptuale a lui Gilles Fauconnier și a lui Mark Turner și reprezintă o încercare de a demonstra cum, prin amalgamarea mai multor spații mentale – de la elemente religioase la personaje și evenimente istorice –, mișcarea a reușit să creeze un univers unic, care-o separă de celelalte mișcări fasciste din epocă. Membrii Legiunii Arhanghelului Mihail erau, în general, extrem de tineri și, după toate aparențele, autentic religioși, practicând un fel de misticism politic greu de găsit în altă parte.
Cuvinte-cheie: discurs, ideologie, linguistică cognitivă, spații mentale, integrarea conceptuală, religii politice
Article history: Received 30 December 2022; Revised 24 February 2023; Accepted 28 February 2023; Available online 27 March 2023; Available print 31 March 2023.
THE LEGITIMIZING TOOLKIT OF THE ROMANIAN COMMUNIST ANTHEMS. IDEOLOGY AND LINGUISTIC IMAGINARY
Authors: URSA Anca 
Published: April 2023

The Legitimizing Toolkit of the Romanian Communist Anthems. Ideology and Linguistic Imaginary. Anthems are associated with nationhood and are part of its legitimizing toolkit. Their complete interpretation usually goes through the analysis of the linguistic imaginary, namely of the mythemes of the age, of the unconscious representations of the community, identifiable in rhythmical patriotic verses. National myths, recycled in patriotic songs Romanians have created since the 19th century, have been coloured differently, according to the ideology of the era. However, during 1948-1989 a double orientation could be “read” in the three national anthems: the natural insinuation of the community’s unconscious projections on the one hand, and the evidence of ideological charge meant to change Romanians’ representations of national reality on the other. Thus, the anthems Broken Shackles (Zdrobite cătușe), We Glorify Thee, Romania (Te slăvim, Românie), and Three colours (Trei culori) mark different stages in the communist discourse, even if they seemingly reuse the same motifs specific to the imaginary of the time: the country, the flag, the proletariat, the victorious past, the bright future and the “crushed” enemies.
REZUMAT. Instrumentarul legitimator al imnurilor comuniste românești. Ideologie și imaginar lingvistic. Imnurile se asociază cu națiunea și fac parte din instrumentarul ei legitimator. Interpretarea completă a acestor creații trece, de obicei, prin analiza imaginarului lingvistic, respectiv a mitemelor epocii, a reprezentărilor inconștiente ale comunității, identificabile în versurile patriotice ritmate. Miturile naționale, reciclate în cântecele patriotice pe care le-au creat românii începând cu secolul al XIX-lea, au fost colorate diferit, în funcție de ideologia epocii. În perioada 1948-1989, în cele trei imnuri naționale, poate fi „citită” însă o dublă orientare: insinuarea firească a proiecțiilor inconștiente ale comunității, pe de o parte, și evidența încărcăturii ideologice, menite să schimbe reprezentările românilor despre realitatea națională, pe de altă parte. Așadar, imnurile Zdrobite cătușe, Te slăvim, Românie și Trei culori marchează etape diferite ale discursului comunist, chiar dacă aparent reiau aceleași motive specifice imaginarului vremii: patria, drapelul, proletariatul, trecutul victorios, viitorul luminos și dușmanii „zdrobiți”. Explorarea imaginarului lingvistic pune în evidență modificările încărcăturii semantice și simbolice, de la un imn la altul.
Cuvinte-cheie: imaginar național, legitimare identitară, miteme, imnuri, patrie, ritual, comunism, limbă de lemn
Article history: Received 5 December 2022; Revised 10 February 2023; Accepted 24 February 2023; Available online 27 March 2023; Available print 31 March 2023
La evolución del vocablo chino <em>xiaoshuo</em> 小说
Authors: Yin Qianyun 
Published: April 2023

Se ha observado un proceso de transformación de las acepciones del término chino xiaoshuo 小说, que en español se ha traducido como “novela”, en la historia china, desde el periodo pre-Qin hasta la víspera de la modernidad. Un breve repaso de los testimonios aparecidos en muchos textos históricos y literarios antiguos revela no sólo los diferentes sentidos del vocablo y traza su trayectoria, sino también el origen y la configuración de la novela como género literario y las fases iniciales de su evolución. En definitiva, las principales acepciones remiten a una connotación de inferioridad y vulgaridad en la novela china en épocas antiguas y premodernas y a su origen relacionado con los recursos orales.