bluuebunny/crossref_metadata_2025_split huggingface dataset:
The physical health nurse consultant and mental health consumer: An important therapeutic partnership
Authors: Tabvuma Tracy , Stanton Robert , Happell Brenda 
Published: December 2022

AbstractPeople diagnosed with mental illness (hereon referred to as consumers) experience a disproportionately lower life expectancy of up 30 years compared to the general population. Systemic issues such as diagnostic overshadowing and stigma from healthcare professionals have inhibited the development of positive therapeutic partnerships that enable consumers to seek and engage support for their physical health concerns. Consumers have called for healthcare professionals to skillfully develop and prioritize therapeutic partnerships whilst coordinating and providing physical healthcare. The aim of this qualitative descriptive research was to explore consumer views and experiences of their interactions with a specialist mental health nursing role, the Physical Health Nurse Consultant. Semi‐structured interviews were conducted with 14 consumers from a large public Community Mental Health Service in the Australian Capital Territory. Interviews were transcribed and thematically analysed. Therapeutic partnerships were an overarching theme identified from the data and included three sub‐themes: personal attributes of the Physical Health Nurse Consultant; behaviour change engagement strategies; and impact of the therapeutic partnership. Consumers described the personal and professional attributes of the Physical Health Nurse Consultant that enabled the establishment and maintenance of their highly valued therapeutic partnership. This therapeutic partnership was perceived to positively impact their personal and clinical outcomes. With increasing support from consumers, clinical practice settings should move towards embedding a Physical Health Nurse Consultant role in routine practice. Further research exploring the co‐development of health behaviour change goals and, barriers and facilitators experienced by the consumers regarding the Physical Health Nurse Consultant is required to further role development.
Ancient vicariance is reinforced by adaptive divergence in the southern beech: Contributions from geogenomics
Authors: Fasanella Mariana , Mathiasen Paula , Juri Gabriela , Díaz Dayana G. , Hasbún Rodrigo , Premoli Andrea C. 
Published: December 2022

AbstractAimGeogenomics seeks to understand geological processes linked to lineage divergence. However, the mechanisms that conserve ancient signals in spite of gene flow are still unclear. In the southern beech, the deep lineage divergence produced by vicariant events is associated with ancient marine transgressions. We hereby evaluate the hypothesis that this divergence is maintained by diversifying selection.LocationSouthern Argentina and Chile.Taxon
Nothofagus dombeyi.
MethodsThe lineage divergence by means of analysis of molecular variance (AMOVA), principal coordinate analysis, assignment tests and multiple matrix regression analyses were assessed using chloroplast DNA and neutral and outlier single nucleotide polymorphisms (SNPs). Several environmental variables were used to characterize potential within‐species niche structuring and genotype–environment associations.ResultsTwo deep‐rooted latitudinally structured lineages resulted from cpDNA, the northern cluster being more genetically diverse than the southern one. Of the total of 2943 SNPs, 33 identified as outliers and produced two genetic clusters. Neutral SNPs yielded no structure by AMOVA, whereas higher (>75%) FST values were obtained for cpDNA and outlier SNPs. Precipitation variables were mostly associated with population clusters and suggested two climatic niches, consisting of cold and dry in the south and more variable precipitation, temperature and soil conditions in the north. Associations of genetic distance with environment and geography suggested isolation‐by‐distance and isolation‐by‐ecology or isolation‐by‐environment effects.Main conclusionsAncient lineage divergence in N. dombeyi, originally driven by vicariance, has been maintained by diversifying selection under distinct environmental conditions that also define distinct within‐species niches. Deeply rooted phylogeographical breaks can be conserved in continuously distributed species in the absence of current geographical barriers. Yet, physical gradients exert differential selective pressures, which are maintained in the face of potential gene flow. As a result, selection can lead to geographically localized and differentially adapted groups of populations that can be detected by a combination of traditional phylogeographical and novel genomic methods.
Modifying enzyme replacement therapy – A perspective
Authors: Schaible Philipp 
Published: December 2022

AbstractSeveral diseases are caused by the lack of functional proteins, including lysosomal storage diseases or haemophilia A and B. Patients suffering from one of these diseases are treated via enzyme replacement therapies to restore the missing protein. Although this treatment strategy prevents some disease symptoms, enzyme replacement therapies are very expensive and require very frequent infusions, which can cause infusion adverse reactions and massively impair the quality of life of the patients. This review proposes a technology to sustainably produce proteins within the patient to potentially make frequent protein‐infusions redundant. This technology is based on blood circulating immune cells as producers of the needed therapeutic protein. To ensure a stable protein concentration over time the cells are equipped with a system, which induces cell proliferation when low therapeutic protein levels are detected and a system inhibiting cell proliferation when high therapeutic protein levels are detected.
Leadership and cooperation in growing teams
Authors: Eisenkopf Gerald , Kölpin Torben 
Published: December 2022

AbstractWe study how the growth of teams affects leadership effectiveness and intragroup cooperation. We put experimental participants in two teams. In each team, the members voluntarily contribute to a club good. In one of the two teams, the members observe the contribution of a randomly chosen leader before they decide themselves. Two treatments allow for migration between the teams. In one of them, participants control access to their team with a voting process. By design, participants can achieve the efficient outcome only if they all move into one team. We compare the results with a leaderless setting as well as with four treatments which vary team size exogenously. The results show that high contributions of leaders encourage higher per‐capita contributions of their followers which foster migration into their teams. In turn, larger teams experience even more courageous leadership and higher contributions, but the coordination effect diminishes. Nevertheless, the dismissal of potential newcomers in the treatment with voting suggests that team members see a trade‐off between team size and contributions. They sacrifice economic benefits from potential entrants to maintain intrateam cooperation.
Across the highest mountain on earth: discordant phylogeographic patterns and recent dispersal of Tibetan stone loaches (Triplophysa) in the Himalayas
Authors: Hu Jiaxin , Zhao Jie , Sui Xiaoyun , Zhu Ren , He Dekui 
Published: December 2022

AbstractPhylogeographic congruence among co‐distributed taxa is regarded as an inherent inference to vicariance events. Nonetheless, incongruent patterns of contemporary lineage divergence among taxa indicated that species differ in their response to common past events. To investigate the role of past events, ecological traits and lineage diversification time in shaping the contemporary phylogeographic patterns, comparative analyses were conducted for Tibetan stone loaches in the Himalayas using three gene markers and two ecological traits (depth of caudal peduncle in their length and presence/absence of posterior chamber of the air bladder). By a thorough sampling in two flanks of the Himalayas, the authors detected that phylogenetic breaks were spatially discordant and divergences of populations were also temporally asynchronous in co‐distributed loaches. Estimated divergence time using fossil‐calibrated node dating indicated that the Tibetan stone loaches colonised into the south flank of the Himalayas until the Pleistocene. The demographic expansions were also disconcerted between populations in north and south flanks, or east and west Himalayas. Ongoing gene flows between populations in north and south sides implied that the Himalayas do not strictly impede dispersal of cold‐adapted species. The results highlight that the quaternary climatic oscillation, in conjunction with ecological traits and lineage diversification time, shaped contemporary phylogenetic patterns of stone loaches in the Himalayas and provide new insights into the biodiversity and composition of species in the Himalayas and surrounding region.
Jaboticaba powders production by freeze‐drying: Influence of octenyl succinic anhydride‐modified starch concentrations over anthocyanins and physical properties
Authors: da Silva Moura Milena , da Silva Gomes da Costa Beatriz , Giaconia Michele Amendoeira , de Andrade Rafael Ramos , Braga Anna Rafaela Cavalcante , Braga Matheus Boeira 
Published: December 2022

AbstractThis research aimed to evaluate the influence of the modified starch with octenyl succinic anhydride (MS) on anthocyanins content and the physical properties of the jaboticaba peel freeze‐dried powders. The formulations were obtained by mixtures of jaboticaba peel pulp and different MS content (10%, 15%, 20%, and 25%, w/w). The powders were characterized by physical properties, differential scanning calorimetry (DSC), infrared spectroscopy using the Fourier transform (FTIR), and anthocyanins content and retention by HPLC‐DAD. DSC analysis showed an increase in the glass transition temperature of the powders with an increase in the MS content (from −10.26°C to 53.40°C). Three anthocyanins were identified and quantified: delphinidin‐3‐O‐glucoside, cyanidin‐3‐O‐glucoside (main anthocyanin present in the samples), and peonidin‐3‐O‐glucoside. The retention of anthocyanins increased significantly with increasing MS content (from 18.0% to 58.0%). Overall, a positive effect of the MS content in the physical and physical–chemical characteristics of jaboticaba peel pulp powders could be observed.
Analysis of 3D elemental distribution in nanomaterials: Towards higher throughput and dose efficiency
Authors: Skorikov Alexander , Batenburg Kees Joost , Bals Sara 
Published: December 2022

AbstractMany advanced nanomaterials rely on carefully designed morphology and elemental distribution to achieve their functionalities. Among the few experimental techniques that can directly visualise the 3D elemental distribution on the nanoscale are approaches based on electron tomography in combination with energy‐dispersive X‐ray spectroscopy (EDXS) and electron energy loss spectroscopy (EELS). Unfortunately, these highly informative methods are severely limited by the fundamentally low signal‐to‐noise ratio, which makes long experimental times and high electron irradiation doses necessary to obtain reliable 3D reconstructions. Addressing these limitations has been the major research question for the development of these techniques in recent years. This short review outlines the latest progress on the methods to reduce experimental time and electron irradiation dose requirements for 3D elemental distribution analysis and gives an outlook on the development of this field in the near future.
Bolstering the rural physician workforce in underserved communities: Are Rural Residency Planning and Development Programs finding the sweet spot?
Authors: Fraher Erin , Page Cristen P. , Hawes Emily M. , Galloway Evan , Pathak Shweta , Tomola Lauren , Holmes George M. 
Published: December 2022

AbstractPurposeThe purpose of this study is to describe the characteristics of Rural Residency Planning and Development (RRPD) Programs, compare the characteristics of counties with and without RRPD programs, and identify rural places where future RRPD programs could be developed.MethodsThe study sample comprised 67 rural sites training residents in 40 counties in 24 US states. Descriptive statistics were used to describe RRPD programs and logistic regression to predict the probability of a county being an RRPD site as a function of population, primary care physicians (PCP) per 10,000 population, and the social vulnerability index (SVI) compared to a control sample of nonmetro counties without RRPD sites.FindingsMost RRPD grantees (78%) were family medicine programs affiliated with medical schools (97%). RRPD counties were more populous (P<.01), had a higher population density (P<.05), and a higher percent of the non‐White or Hispanic population (P = .05) compared to non‐RRPD counties. Both higher population (P<.001) and PCP ratio (P = .046) were strong predictors, while SVI (P = .07) was a weak predictor of being an RRPD county.ConclusionsRRPD sites appear to represent a “sweet spot” of rural counties that have the population and physician supply to support a training program but also are relatively more socially vulnerable with high‐need populations. Additional counties fitting this “sweet spot” could be targeted for funding to address health disparities and health workforce maldistribution.
Periodic leg movements during sleep and iron status in infants with prematurity, Down syndrome and Prader–Willi syndrome
Authors: DelRosso Lourdes M. , Mindell Jodi , Bruni Oliviero , Mogavero Maria P. , Ferri Raffaele 
Published: December 2022

SummarySleep disturbances including bedtime problems and night awakenings are common during infancy. Polysomnography during the first years of life is performed mainly to rule out sleep‐disordered breathing; however, sleep‐related movement disorders can constitute a significant contributor to sleep disruption in this age group. Almost no studies have investigated the presence of periodic limb movements during sleep and underlying iron deficiency in infants, especially in those born preterm or with an underlying genetic syndrome. In this retrospective study we included infants 3–24 months referred for polysomnography for snoring or frequent nocturnal awakenings. All children had bloodwork (ferritin and haemoglobin) conducted within 3 months of the overnight sleep study. We studied 79 infants, including 31 (39.2%) full‐term without diagnosis, 10 (12.7%) born premature, 16 (20.3%) with Down syndrome, 15 (19.0%) with Prader–Willi syndrome, and the remaining seven (8.9%) had various disorders. Compared with those with Down syndrome, Prader–Willi syndrome and full‐term infants, those with prematurity showed a statistically significant elevated periodic limb movement index and lower ferritin levels than the other groups. Both ferritin (r = −0.18) and haemoglobin (r = −0.30) were negatively correlated with periodic limb movement index; however, this correlation reached statistical significance only for haemoglobin. Iron deficiency is associated with increased periodic leg movements during sleep in infants. Infants with prematurity had higher periodic limb movement index and lower ferritin levels than infants with Down syndrome, Prader–Willi syndrome or without diagnosis.
Immunotherapy in hepatocellular carcinoma: How does underlying liver disease influence therapeutic strategy and outcomes?
Authors: Roth Gael S. , Villeret François , Decaens Thomas , Merle Philippe , Nahon Pierre 
Published: December 2022

AbstractHepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide, with up to 90% of HCC cases occurring in the setting of underlying cirrhosis. Therapeutic landscape for advanced HCC has dramatically changed in recent years with the advent of immunotherapy, including several combinations. Data suggest that the surrounding liver milieu may influence tumour response. In addition, different aetiologies of HCC and their effects on the host liver may impact response to immunotherapy. However, to date, guidelines do not take into account this parameter to guide therapeutic selection, and phase III trials are likewise performed in patients irrespective of HCC aetiology. Moreover, most clinical trial data are collected in highly selected patients with preserved liver function (defined as Child‐Pugh class A) and controlled portal hypertension, which does not accurately reflect routine clinical practice. In this review, we discuss the influence of liver disease aetiology on the response to immunotherapy in patients with advanced HCC. We also discuss the safety and efficacy of various immunotherapeutic agents in Child‐Pugh B patients to determine if these treatments are beneficial in this vulnerable patient population.
Left ventricular pacing in the treatment of pediatric cardiac dysfunction caused by idiopathic complete left bundle branch block
Authors: Li Xiaomei , Li Jinghao , Jin Yongqiang , Jiang He , Cui Jian , Zhang Yi , Li Meiting , Zhou Huiming 
Published: December 2022

AbstractObjectiveThis study aimed to investigate the feasibility and effectiveness of transthoracic epicardial dual‐chamber pacemaker implantation in the treatment of cardiac dysfunction caused by idiopathic complete left bundle branch block (CLBBB) in children.MethodsNine children diagnosed with cardiac dysfunction due to idiopathic CLBBB were included in this study. All patients underwent transthoracic epicardial dual‐chamber pacemaker implantation. Cardiac function was evaluated using echocardiography during the follow‐up. Additionally, intraventricular synchronization parameters were assessed using two‐dimensional speckle tracking echocardiography (STE).ResultsNine children (mean age, 3.0 ± 2.6 years) were included in this study. The median follow‐up duration was 2 (interquartile range, 1–3) years. The cardiac function of all patients recovered to normal levels within 1 year postoperatively. The postoperative QRS duration on electrocardiography (142 ± 21 ms) was significantly shorter than that at baseline (106 ± 12 ms) (p < .05). Cardiac dyssynchrony in patients who manifested preoperatively achieved complete correction after pacemaker implantation. The comparison of preoperative and postoperative (last follow‐up visit) synchronization parameters were as follows: longitudinal standard deviation of the time to peak strain, 99.0 ± 41.9 versus 36.8 ± 5.0 ms (p = .004); delay time of peak longitudinal strain, 252.2 ± 131.4 versus 35.0 ± 22.9 ms (p = .002); and longitudinal systolic dyssynchrony index, 2.8 ± 0.8% versus 1.0 ± 0.3% (p = .001), respectively.ConclusionTransthoracic epicardial dual‐chamber pacemaker implantation (with left atrial sensing and left ventricular single‐site pacing) can be used for the treatment of cardiac dysfunction caused by idiopathic CLBBB in children.
Serial Cross‐Sectional Observations of Sun‐Protective Behaviors at an Annual Outdoor Motorsport Event in Tropical Queensland, Australia
Authors: Dexter Ben , Smith Annika , King Rachel , Downs Nathan J. , Nikles Catherine Jane , Parisi Alfio V. , Ho Yik‐Hong , Harrison Simone Lee 
Published: December 2022

AbstractSkin cancer, the most prevalent cancer in Caucasians residing at low latitudes, can primarily be prevented by avoiding overexposure to sunlight. Serial cross‐sectional observations were conducted at an outdoor motorsport event held in Townsville, Queensland each July (Southern winter) to determine whether sun‐protection habits changed over time. Most (71.1%) of the 1337 attendees observed (97.6% lightly pigmented skin, 64.0% male) wore a hat (any style shading the face), while few (18.5%) wore three‐quarter or full‐length sleeves. While hat‐wearing rates (any style) were similar in 2009 (326, 72.6%) and 2013 (625, 70.4%), the use of sun‐protective styles (wide‐brimmed/bucket/legionnaires) decreased from 29.2% to 18.6% over the same period, primarily because the use of sun‐protective hats halved (from 28.7% to 14.0%) among females, while decreasing from 29.4% to 21.1% in males. Although relatively few individuals wore sun‐protective (three‐quarter‐length or full‐length) sleeves regardless of year (OR = 0.117, P < 0.0001), encouragingly, the use of sun‐protective sleeves more than doubled between 2009 (10.5%) and 2013 (22.5%). Interestingly females, albeit the minority, at this sporting event were less likely to wear a hat (OR = 0.473, P < 0.0001) than males. These findings highlight the need for continued momentum toward skin cancer primary prevention through sun protection with a dedicated focus on outdoor sporting settings.
Statistics in Times of Increasing Uncertainty
Authors: Richardson Sylvia 
Published: December 2022

AbstractThe statistical community mobilised vigorously from the start of the 2020 SARS-CoV-2 pandemic, following the RSS's long tradition of offering our expertise to help society tackle important issues that require evidence-based decisions. This address aims to capture the highlights of our collective engagement in the pandemic, and the difficulties faced in delivering statistical design and analysis at pace and in communicating to the wider public the many complex issues that arose. I argue that these challenges gave impetus to fruitful new directions in the merging of statistical principles with constraints of agility, responsiveness and societal responsibilities. The lessons learned from this will strengthen the long-term impact of the discipline and of the Society. The need to evaluate policies even in emergency, and to strive for statistical interoperability in future disease surveillance systems is highlighted. In my final remarks, I look towards the future landscape for statistics in the fast-moving world of data science and outline a strategy of visible and growing engagement of the RSS with the data science ecosystem, building on the central position of statistics.
Do green policies produce green jobs?
Authors: Woods Neal D. , Kang Jiyoon , Lowder Morgan A. 
Published: December 2022

AbstractObjectiveWe examine the relationship between clean energy policies and green job growth.MethodsUsing a set of meta‐regression analyses, we assess the green job creation performance of a wide variety of policies in the American states.ResultsOur findings indicate that renewable portfolio standards and public benefit funds are systematically associated with increases in green jobs, although the effects of other policy tools are ambiguous at best. Effect estimates in the existing literature are significantly driven by how the dependent and core independent variables are measured.ConclusionOverall, our findings suggest that some policies may be an effective component of an energy‐based economic development strategy, but that for others a more robust evidence base is needed in order to clarify their effects.