bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary vein isolation‐induced vagal nerve injury and gastric motility disorders detected by electrogastrography: The side effects of pulmonary vein isolation in atrial fibrillation (SEPIA) study
Authors: Grosse Meininghaus Dirk , Freund Robert , Kleemann Tobias , Geller Johann Christoph , Matthes Harald 
Published: January 2023

AbstractIntroductionSafety of pulmonary vein isolation (PVI) has been established in clinical studies. However, despite prevention efforts the incidence of damage to (peri)‐esophageal tissue has not decreased, and the pathophysiology is incompletely understood. Damage to vagal nerve branches may be involved in lesion progression to atrio‐esophageal fistula. Using electrogastrography, we assessed the incidence of periesophageal vagal nerve injury (VNI) following atrial fibrillation ablation and its association with procedural parameters and endoscopic results.MethodsPatients were studied using electrogastrography, endoscopy, and endoscopic ultrasound before and after cryoballoon (CB) or radiofrequency (RF) PVI. The incidence of ablation‐induced neuropathic pattern (indicating VNI) in pre‐ and postprocedural electrogastrography was assessed and correlated with endoscopic results and ablation data.ResultsBetween February 2021 und January 2022, 85 patients (67 ± 10 years, 53% male) were included, 33 were treated with CB and 52 with RF (38 with moderate power moderate duration [25–30 W] and 14 with high power short duration [50 W]). Ablation‐induced VNI was detected in 27/85 patients independent of the energy form. Patients with VNI more frequently had postprocedural endoscopically detected pathology (8% mucosal esophageal lesions, 36% periesophageal edema, 33% food retention) but there was incomplete overlap. Pre‐existing esophagitis increased the likelihood of VNI. Ablation data and esophageal temperature data did not predict VNI.ConclusionPVI‐induced VNI is quite common and independent of ablation energy source. VNI is part of (peri)‐esophageal damage and only partially overlaps with endoscopic findings. VNI‐associated acidic reflux may be involved in the complex pathophysiology of esophageal lesion progression to fistula.
Effect of administration of low‐dose irbesartan and hydrochlorothiazide combined with levamlodipine at different times on the circadian rhythm of blood pressure and the levels of MMPs and TIMPs in non‐dipper patients with grade 1 and 2 hypertension
Authors: Yan Peiling , Luo Yongjian , Zhang Jiancheng , Liu Haifeng , Chen Jiashi , Wang Jing , Dong Guofeng , Ge Minghao 
Published: January 2023

AbstractThis study aimed to probe the effects of low‐dose irbesartan and hydrochlorothiazide in combination with levamlodipine at different times on the circadian rhythm of blood pressure, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) levels in patients with non‐dipper hypertension (NDH). In this prospective randomized controlled trial, 124 patients with NDH who visited our hospital between August 2018 and July 2021 were enrolled and divided into morning (62 patients) and night (62 patients) medication groups according to the random number table method. All patients received low‐dose irbesartan and hydrochlorothiazide combined with levamlodipine, with the morning medication group taking the medication between 7:00 and 10:00 and the night medication group taking the medication between 19:00 and 22:00 for 24 weeks. The effect of antihypertensive medication in both groups was measured, and changes in ambulatory blood pressure, blood pressure circadian rhythm, left ventricular structure, vascular endothelial function, MMPs, and TIMPs levels were observed before treatment initiation and after 24 weeks of treatment in both groups. The percentage of the dipper type was higher in the night medication group than in the morning medication group, while the percentage of the non‐dipper type was lower in the morning medication group (p < .05). Low‐dose irbesartan and hydrochlorothiazide combined with levamlodipine at different times can effectively treat NDH, but bedtime dosing is more beneficial in reducing nocturnal blood pressure, reversing NDH, improving the circadian rhythm of blood pressure, left ventricular structure, regulating vascular endothelial function, increasing MMPs levels, and reducing TIMP levels.
A guide for maximizing the accuracy of intraoral digital scans: Part 2—Patient factors
Authors: Revilla‐León Marta , Kois Dean E. , Kois John C. 
Published: January 2023

AbstractObjectivesTo describe the factors related to patient intraoral conditions that impact the scanning accuracy of intraoral scanners (IOSs). A new classification for these influencing factors is proposed to facilitate dental professionals' decision‐making and maximize the accuracy and reliability of intraoral digital scans.OverviewVariables related to intraoral conditions of the patient that can influence the scanning accuracy of IOSs include tooth type, presence of interdental spaces, arch width variations, palate characteristics, wetness, existing restorations, characteristics of the surface being digitized, edentulous areas, interimplant distance, position, angulation, and depth of existing implants, and implant scan body selection.ConclusionsThe knowledge and understanding of the patient's intraoral conditions that can impact the scanning accuracy of IOSs is a fundamental element for maximizing the accuracy of IOSs.Clinical SignificanceThe patient's intraoral conditions, or patient factors, can significantly impact intraoral scanning accuracy. Dental professionals must know and understand these influencing patient factors to maximize the accuracy of IOSs.
Ohmic heating using electrolytes for paddy parboiling: A study on thermal profile, electrical conductivity, milling quality, and nutritional attributes
Authors: D'cruz Vidya , Chandran Monisha , Athmaselvi KA , Rawson Ashish , Natarajan Venkatachalapathy 
Published: January 2023

AbstractOhmic heating (OH), a novel thermal technique could be utilized for paddy parboiling to improve milled rice quality. In this research, two paddy varieties (one traditional and one modern variety) were subjected to OH at different salt concentrations (0%, 0.3%, 0.5%, 0.7%, and 0.9%) and voltage gradients (10, 12, 14, 16, and 18 V/cm) and their influence on thermal profile, electrical conductivity (EC), milled rice quality, and nutritional profile were studied in comparison to the conventional steaming method. A factorial design was used to determine the effect of variety, voltage gradient and holding time on head rice yield (HRY), hardness and color difference of parboiled milled rice. Results indicated the significance of salt and voltage on processing time and HRY. On increasing, both enhanced the EC and heating rate leading to a great reduction in parboiling duration whereas HRY increased on lowering the voltage. High significant effects were observed between the factors for HRY and color. The maximum HRY and hardness were obtained for OH at 0.7% salt and 12 V/cm. This treatment when compared to steaming, consumed less energy, and provided less chalkiness, better HRY and hardness for both varieties to a greater extent. OH also positively impacted the nutritional profile of parboiled rice as it retained more protein and fat than the conventional method. These results reveal the superiority of OH in providing a significant favorable impact on the parboiled milled rice quality and has a great potential to be used for paddy parboiling.Practical applicationsOhmic heating is an emerging thermal technique having the potential for rapid uniform heating. In this study, OH was utilized for paddy parboiling by incorporating electrolytes for replacing the conventional steaming method. Steaming requires a boiler for generating steam, which adds to the processing cost and equipping OH eliminates the need for a boiler. This will save water, energy, space, manpower, and maintenance requirements. OH also reduces the parboiling duration, while improving parboiled rice quality. The ohmic behavior of paddy will also facilitate the design of continuous ohmic systems for paddy parboiling which can be immensely useful in the rice processing industry.
Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex perianal fistula in non‐Crohn's cases: Clinical trial phase I
Authors: Pak Haleh , Hadizadeh Alireza , Heirani‐Tabasi Asieh , Soleimani Masoud , Asbagh Reza Akbari , Fazeli Mohammad Sadegh , Kazemeini Alireza , Keshvari Amir , Keramati Mohammad Reza , Salahshour Faezeh , Nazari Hengameh , Tafti Seyed Mohsen Ahmadi , Behboudi Behnam 
Published: January 2023

AbstractBackground and AimA perianal fistula is an abnormal tract that connects anal canal to skin. Current medical and surgical interventions have a high failure rate particularly in complex and refractory cases. MSC‐derived exosomes have demonstrated immunomodulatory effects without the conventional complications; hence, in this study, we evaluated the safety of their application for complex perianal fistula.MethodsPlacenta‐derived MSCs were cultured, and exosomes were isolated using ultracentrifugation. Exosome injections were administered in the operating room to 11 patients with complex perianal fistula (presence of fistulas for at least 1 year alongside medical and surgical treatment). The patients were followed for 6 months, and the patients were evaluated using physical examination, face‐to‐face interviews, and magnetic resonance imaging (MRI).ResultsAmong 11 patients only one did not show any improvement upon physical examination. Five patients showed complete tract resolve. While the discharge was stopped in eight patients, two patients showed only reduction. None of the patients showed any acute or latent allergic reaction or injection related complications.ConclusionAdministration of exosomes isolated from MSCs demonstrates safety and a satisfactory therapeutic effect in treatment complex perianal fistulae; therefore, it can be a candidate for future studies and might play a significant role in treatment.
Geminiviral C2 proteins inhibit active autophagy to facilitate virus infection by impairing the interaction of ATG7 and ATG8
Authors: Cao Buwei , Ge Linhao , Zhang Mingzhen , Li Fangfang , Zhou Xueping 
Published: January 2023

ABSTRACTAutophagy is a conserved intracellular degradation process that plays an active role in plant response to virus infections. Here we report that geminiviruses counteract activated autophagy‐mediated antiviral defense in plant cells through the C2 proteins they encode. We found that, in Nicotiana benthamiana plants, tomato leaf curl Yunnan virus (TLCYnV) infection upregulated the transcription levels of autophagy‐related genes (ATGs). Overexpression of NbATG5, NbATG7, or NbATG8a in N. benthamiana plants decreased TLCYnV accumulation and attenuated viral symptoms. Interestingly, transgenic overexpression of NbATG7 promoted the growth of N. benthamiana plants and enhanced plant resistance to TLCYnV. We further revealed that the C2 protein encoded by TLCYnV directly interacted with the ubiquitin‐activating domain of ATG7. This interaction competitively disrupted the ATG7–ATG8 binding in N. benthamiana and Solanum lycopersicum plants, thereby inhibiting autophagy activity. Furthermore, we uncovered that the C2‐mediated autophagy inhibition mechanism was conserved in three other geminiviruses. In summary, we discovered a novel counter‐defensive strategy employed by geminiviruses that enlists their C2 proteins as disrupters of ATG7–ATG8 interactions to defeat antiviral autophagy.
Relationship dynamics associated with emotional IPV perpetration and victimization: A meta‐analysis
Authors: Keilholtz Brooke M. , Spencer Chelsea M. , Vail Summer , Palmer Megan 
Published: January 2023

AbstractEmotional intimate partner violence (IPV) is the most common form of IPV and frequently co‐occurs with other forms of IPV. Risk factors of IPV can give insight to potential pathways and consequences associated with IPV, enhancing treatment efforts. This meta‐analysis examined relationship dynamics associated with IPV perpetration and victimization. Our study found victimization of controlling behavior, demand/withdrawal relationship pattern, perpetration of controlling behavior, jealousy, relationship distress, perpetrator's power in the relationship, anxious attachment, and traditional gender roles were all significantly associated with IPV perpetration. For IPV victimization, victimization of controlling behaviors, fear of the perpetrator, relationship distress, anxious and avoidant attachment, and traditional gender roles were all found to be significantly associated. Relationship satisfaction was found to be negatively associated with emotional IPV perpetration and victimization. Implications for clinicians are discussed.
A method for reproducible high‐resolution imaging of 3D cancer cell spheroids
Authors: Phillips Thomas A. , Caprettini Valeria , Aggarwal Nandini , Marcotti Stefania , Tetley Rob , Mao Yanlan , Shaw Tanya , Chiappini Ciro , Parsons Maddy , Cox Susan 
Published: January 2023

AbstractMulticellular tumour cell spheroids embedded within three‐dimensional (3D) hydrogels or extracellular matrices (ECM) are widely used as models to study cancer growth and invasion. Standard methods to embed spheroids in 3D matrices result in random placement in space which limits the use of inverted fluorescence microscopy techniques, and thus the resolution that can be achieved to image molecular detail within the intact spheroid. Here, we leverage UV photolithography to microfabricate PDMS (polydimethylsiloxane) stamps that allow for generation of high‐content, reproducible well‐like structures in multiple different imaging chambers. Addition of multicellular tumour spheroids into stamped collagen structures allows for precise positioning of spheroids in 3D space for reproducible high‐/super‐resolution imaging. Embedded spheroids can be imaged live or fixed and are amenable to immunostaining, allowing for greater flexibility of experimental approaches. We describe the use of these spheroid imaging chambers to analyse cell invasion, cell–ECM interaction, ECM alignment, force‐dependent intracellular protein dynamics and extension of fine actin‐based protrusions with a variety of commonly used inverted microscope platforms. This method enables reproducible, high‐/super‐resolution live imaging of multiple tumour spheroids, that can be potentially extended to visualise organoids and other more complex 3D in vitro systems.
Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR‐590‐5p/CCR7 axis
Authors: Yu Huan‐Huan , Zhao Wei , Zhang Bu‐Xin , Wang Ying , Li Jie , Fang Yu‐Fu 
Published: January 2023

AbstractBackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic predisposition, and the traditional Chinese medicine Morinda officinalis and its roots are characterized with anti‐inflammatory effects and have been used for the treatment of various disease. However, it is still largely unknown whether Morinda officinalis extract (MOE) can be used for the treatment of AD.ObjectivesIn our study we aimed to determine whether MOE could ameliorate 2,4‐dinitrochlorobenzene (DNCB)‐induced AD and elucidate molecular mechanisms.MethodsWe established an AD mouse model by using DNCB. Skin pathological analysis and ELISA assay were used to detect the effect of MOE on the inflammation of AD model mouse skin and the expression changes of inflammatory factors, and further functional verification was performed in TNF‐α/IFN‐γ‐induced HaCaT cells.ResultsOur in vivo experiments confirmed that MOE remarkably reduced DNCB‐induced AD lesions and symptoms, such as epidermal and dermal thickness and mast cell infiltration and inflammatory cytokines secretion in the mice models. In addition, the underlying mechanisms by which MOE ameliorated AD had been uncovered, and we verified that MOE inhibited MALAT1 expression in AD, resulting in attenuated expression of C‐C chemokine receptor type 7 (CCR7) regulated by MALAT1‐sponge miR‐590‐5p in a competing endogenous RNA (ceRNA) mechanisms‐dependent manner, thereby inhibiting TNF‐α/IFN‐γ‐induced cellular proliferation and inflammation.
Loan‐to‐value limits as a macroprudential policy tool: Developments in theory and practice
Authors: Gatt William 
Published: January 2023

AbstractI analyze the development of the loan‐to‐value (LTV) ratio limit for households as a macroprudential policy tool in both theory and practice, by surveying theoretical and empirical literature. I argue that the practical implementation of LTV caps preceded theoretical studies, but research has caught up since the global financial crisis, including research on which indicators seem to work best in flagging a potential future crisis. In practice, LTV ratio limits tend to be effective tools in buffering credit and house price growth, although attributing casual effects in empirical studies is not always straightforward. The benefits of LTV policy seem to outweigh some potential side‐effects, such as the output costs of tightening credit. I then survey the recent success with LTV policy in New Zealand and Ireland, particularly by targeting the riskier borrowers. Their experience reveals that learning and fine‐tuning of LTV policies along the way are inevitable.
Cytomorphology and immunocytochemical features of ovarian granulosa cell tumors in ascites or peritoneal washings: A retrospective review
Authors: Zhang Xinying , Pang Shujie , Liu Yixin 
Published: January 2023

AbstractAimTo summarize the cytomorphology and immunocytochemistry features of OGCT in ascites or peritoneal washings.MethodsAll cases of histology sections, cytology smears, cell block slides and immunohistochemical staining were reviewed. A panel of immunohistochemistry antibodies consisting of Inhibin, Calretinin, BerEP4 and MC was performed for diagnosis and differential diagnosis.ResultsSeven positive cases (21.2%) in ascites and peritoneal washings were identified in 33 patients with OGCT, which is higher than early studies with positive rate of 7.4%. Clinicopathologic features including tumor size and the incidence of endometrial atypical hyperplasia or carcinoma (EAH/EC) displayed no statistical difference between groups with positive and negative cytology. Immunocytochemical results usually showed typical staining pattern with α‐inhibin, calretinin positive and BerEP4, MC negative. Features of granulosa cells, including nuclear hyperplasia and overlapping, can be observed in all seven positive cases. Nuclear grooves or small conspicuous nucleoli were occasionally observed in the smear. However, features of cell clusters mimicking Call‐Exner bodies, cytoplasmic vacuoles or single cell necrosis were not found on smear. Call‐Exner bodies and mitosis can only be found on cell blocks. All cases of follow‐up information were available and three cases displayed progression and there was a statistical difference between groups with positive and negative cytology.ConclusionOGCT with positive cytology in ascites and peritoneal washings tend to have a larger tumor size and higher rates of disease progression. A panel of complementary biomarkers can greatly increase the detection rate and help in differential diagnosis in ascites or peritoneal washings of OGCT.
A Person Without a Past: Robert Michels and Alfred Schutz and the Sociology of the “Stranger”
Authors: Adair‐Toteff Christopher 
Published: January 2023

AbstractRobert Michels and Alfred Schutz might not seem to have much in common. Michels was a political sociologist and Schütz was a philosopher of phenomenology, but they shared one crucial thing: they were both strangers in foreign countries. Michels left Germany for Italy and Switzerland because he was not permitted to complete the second degree necessary to teach at the university level while Schutz was compelled to leave Austria for France and the United States because of his Jewish background. Their experiences of trying to adapt in a foreign country prompted them to reflect on what it means to be “the stranger” (“Der Fremde”). Michels wrote “Materialien zu einer Soziologie des Fremden” in 1925 and Schutz published “The Stranger: An Essay in Social Psychology” in 1944. While Schutz’ article has been repeatedly cited, there does not seem to be a study devoted to it. Michels' article remains among his most neglected writings. However, both works offer a theoretical and contextual account of the obstacles the stranger encounters when trying to understand and to acclimate oneself to a new environment. As Schutz noted, the stranger is a person “without a past”, and Michels suggested, is also a person with an uncertain future.
Effectiveness of sound and darkness interventions for critically ill patients' sleep quality: A systematic review and component network meta‐analysis
Authors: Fang Chiu‐Shu , Tu Yu‐Kang , Chang Shih‐Lun , Kuo Chia‐Chi , Fang Ching‐Ju , Chou Fan‐Hao 
Published: January 2023

AbstractBackgroundNoise and lighting are prime factors of poor sleep quality in critically ill patients, which impair recovery and increase the risk of delirium or complications.AimTo identify and rank the effectiveness of sound and darkness interventions on the sleep quality of critically ill patients.Study DesignThis systematic review and component network meta‐analysis was based on the Preferred Reporting Items for Systematic Reviews incorporating the Network Meta‐Analyses (PRISMA‐NMA) Statement. The Embase, MEDLINE, Cochrane CENTRAL, CINAHL, Airiti Library, and Google Scholar databases were searched from inception to August 10, 2021, for randomized controlled trials (RCTs) on sound and darkness interventions targeting critically ill patients' sleep quality. We applied standard and component NMA to determine the effects of interventions. The certainty of evidence was evaluated using the Cochrane risk‐of‐bias tool (V.2.0) and the online Confidence in Network Meta‐Analysis (CINeMA) application.ResultsTwenty‐four RCTs with 1507 participants who used combined interventions constituting seven competing interventions were included in the standard NMA. The combination of earplugs, eye masks, and music; eye masks alone; earplugs combined with eye masks; and music alone had beneficial intervention effects. The combination of earplugs, eye masks, and music was the best intervention, and these components had no interaction effect. An eye mask had the best relative effect, followed by music, quiet time, and earplugs.ConclusionsThis study provides clinical evidence of the effectiveness of using eye masks, music, and earplugs to improve sleep quality in critically ill patients. We also recommend future research using bedtime music, nocturnal eye masks, and quiet time, which had the best relative effects on sleep quality.Relevance to clinical practiceThis study provides recommendations for interventions that nurses can use to improve critically ill patients' sleep quality.