bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of AMO HR practices and knowledge sharing in developing a learning organizational culture: evidence from the United Kingdom
Authors: Naqshbandi M. Muzamil , Meeran Sheik , Kim Minseo , Mughal Farooq 
Published: August 2023

Purpose
This study aims to explore how the three types of human resource (HR) practices, encapsulated in the ability, motivation and opportunity (AMO) model, foster a learning organizational culture (LOC). In doing so, the authors evaluate the centrality of knowledge sharing (KS) in mediating this relationship.

Design/methodology/approach
A quantitative survey is undertaken to collect data from managers working in organizations operating in the UK. The authors use several statistical techniques to assess the psychometric properties of the measures and test the hypotheses using multiple regression executed with Preacher and Hayes’ Process macro.

Findings
The findings show that the AMO HR practices significantly facilitate the development of a LOC in the workplace, and KS among organizational members amplifies the effects of these HR practices in the process.

Originality/value
A LOC functions as an important source of organizational performance and effectiveness. It enhances the absorptive capacity of the organization to capture, share and transfer knowledge to optimize work. Hence, developing a culture that nurtures organizational learning could be a priority for managing HR. This study, therefore, extends the understanding of the role of AMO HR practices in fostering a learning culture – thus, providing managers with the essential knowledge to improve performance. The study also enriches the literature on HR practices, KS and LOC by integrating these three variables into a unifying framework.
Physical or digital media: the mediating role of psychological ownership
Authors: Stough Rusty , Graham Christian 
Published: August 2023

PurposeAccess to media is more available now than ever before, both physically and digitally. This study was used to investigate the underlying personality traits that influence the decision to purchase either physical or digital books, and extend theory on access to art and provide a unique lens through which marketers can sell digital media.Design/methodology/approachStudy 1 is a field study in which data were collected from several comic book readers and collectors to look at the role that psychological ownership plays in influencing the likelihood of buying physical or digital comics. Specifically, study 1 includes consumers' need for uniqueness and tech savviness as potential influencers. Study 2 extends the findings of study into a new context and manipulates, rather than measures, the identity of the participants. Study 2 looks at the effects of turning a digital object into a non-fungible token (NFT).FindingsThis paper demonstrates that consumers who have a high consumer need for uniqueness (CNFU) are more likely to prefer physical media to digital media. Further, it is shown that preference for physical media leads, on average, to more purchases and that the consumer's psychological ownership mediates the effects of CNFU. In addition, this paper shows that higher degrees of tech savviness led to a preference for digital media. Finally, this paper shows that when consumers identify with a collector identity, turning a digital item into an NFT increases their preference for that object.Originality/valueThis work builds off recent research into physical and digital media and is one of the first to examine the specific personality types that prefer each.
Cognitive style, entrepreneurial leadership and career success: the moderating role of social norms
Authors: Zhang Dixuan , Wang Xiaohong , Zhang Shaopeng 
Published: August 2023

PurposeDrawing on self-determination theory, this study reveals the formative and functional mechanism of entrepreneurial leadership and constructs an integrated model that combines objective and subjective career success.Design/methodology/approachUsing data from 189 leaders from China, this study examined the relationship among cognitive style, social norms, entrepreneurial leadership and career success. Using SPSS version 25.0 and AMOS version 23.0, factor analysis, correlation, path analysis and moderation analysis were performed.FindingsThe results indicated that innovative cognitive style is positively related to entrepreneurial leadership, and this relationship is reinforced by social norms. Adaptive cognitive style is negatively related to entrepreneurial leadership, but this relationship is not regulated by social norms. Besides, this study found a significantly positive relationship between entrepreneurial leadership and objective career success, while entrepreneurial leadership does not demonstrate a significant relationship with subjective career success.Originality/valueBy combining subjective and the objective career success into entrepreneurial leadership research, the findings provide a new perspective for understanding what other experiences entrepreneurship can bring to leaders. Furthermore, the current study analyzes the informal institutional environment's promoting and impeding roles between cognitive style and entrepreneurial leadership.
Factors influencing the financial satisfaction of MSME owners: the mediating role of access to Islamic financing
Authors: Mahmoud Mahmoud Ahmad , Umar Umar Habibu , Ado Muhammad Bilyaminu , Kademi Tasiu Tijjani 
Published: August 2023

Purpose
The purpose of this study is to extend the extant literature on the relationship between financial risk tolerance (FRT), awareness of Islamic financial principles (AWIF) and positive financial behaviour (FB) on financial satisfaction (FS) of micro, small and medium enterprise (MSME) owners by principally investigating the mediating effect of access to Islamic financing (AIF) on these relationships.

Design/methodology/approach
A quantitative survey method of data collection through a self-administered questionnaire. The sample of 384 MSME owners was selected in which 208 questionnaires were retrieved and analysed using the partial least square structural equation modelling (SEM).

Findings
The result shows that the relationships between FRT and AIF as well as FB and AIF are not significant. However, the AWIF–AIF relationship was found to be positively significant. Moreover, only the mediating effect of AIF on the AWIF–FS relationship was established.

Practical implications
The result implies that AIF could strongly influence the FS of MSME owners, and the AWIF–FS relationship is better explained with sufficient AIF. However, AIF could not mediate the relationships between FRT–FS and FB–FS. Therefore, policymakers and MSME owners should emphasize on AWIF and AIF to enhance FS.

Originality/value
This study pioneers the examination of the mediating influence of AIF on FRT, AWIF, FB and FS of MSME owners in a single framework. Despite the importance of MSME owners on economic sustainability, literature on MSME owners' FS is lacking expressly among developing countries, particularly in Nigeria. This study also revealed new theoretical and practical knowledge by illuminating the mediating effect of AIF on AWIF–FS relationship.
Mid‐trimester uterine artery Doppler for aspirin discontinuation in pregnancies at high risk for preterm pre‐eclampsia: Post‐hoc analysis of StopPRE trial
Authors: Bonacina Erika , Garcia‐Manau Pablo , López Monica , Caamiña Sara , Vives Àngels , Lopez‐Quesada Eva , Ricart Marta , Maroto Anna , de Mingo Laura , Pintado Elena , Castillo‐Ribelles Laura , Martín Lourdes , Rodriguez‐Zurita Alicia , Garcia Esperanza , Pallarols Mar , Vidal‐Sagnier Laia , Teixidor Mireia , Orizales‐Lago Carmen , Pérez‐Gomez Adela , Ocaña Vanesa , Puerto Linda , Millán Pilar , Alsius Mercè , Diaz Sonia , Maiz Nerea , Carreras Elena , Suy Anna , Mendoza Manel 
Published: August 2023

AbstractObjectiveTo assess whether aspirin treatment can be discontinued in pregnancies with normal uterine artery pulsatility index (≤90th percentile) at 24–28 weeks.DesignPost‐hoc analysis of a clinical trial.SettingNine maternity hospitals in Spain.Population or SamplePregnant individuals at high risk of pre‐eclampsia at 11–13 weeks and normal uterine artery Doppler at 24–28 weeks.MethodsAll participants received treatment with daily aspirin at a dose of 150 mg. Participants were randomly assigned, in a 1:1 ratio, either to continue aspirin treatment until 36 weeks (control group) or to discontinue aspirin treatment (intervention group), between September 2019 and September 2021. In this secondary analysis, women with a UtAPI >90th percentile at 24–28 weeks were excluded. The non‐inferiority margin was set at a difference of 1.9% for the incidence of preterm pre‐eclampsia.Main outcome measuresIncidence of preterm pre‐eclampsia.ResultsOf the 1611 eligible women, 139 were excluded for UtAPI >90th percentile or if UtAPI was not available. Finally, 804 were included in this post‐hoc analysis. Preterm pre‐eclampsia occurred in three of 409 (0.7%) women in the aspirin discontinuation group and five of 395 (1.3%) women in the continuation group (−0.53; 95% CI −1.91 to 0.85), indicating non‐inferiority of aspirin discontinuation.ConclusionsDiscontinuing aspirin treatment at 24–28 weeks in women with a UtAPI ≤90th percentile was non‐inferior to continuing aspirin treatment until 36 weeks for preventing preterm pre‐eclampsia.
Impact of COVID‐19 and restricted self‐help group attendance on drinking behavior among people with alcohol use disorder: Results of a nationwide cross‐sectional survey
Authors: Nitta Chie , Matsushita Sachio 
Published: August 2023

AbstractBackgroundConcerns regarding symptom severity and the risk of relapse among people seeking recovery from alcohol use disorder (AUD) have been raised since the onset of the COVID‐19 pandemic. Owing to preventive measures implemented during the pandemic (social distancing or lockdown), self‐help group (SHG) meetings were restricted. However, the impact of deprivation of onsite recovery meetings on drinking behavior and risk among SHG members with AUD remains unclear. We examined the proportion of SHG members who reported drinking and their reasons for drinking during the early stages of the pandemic and the effect of nonattendance at onsite recovery meetings on drinking behavior during the early pandemic period, stratified by gender.MethodsA national cross‐sectional survey of Japanese SHG members was conducted to measure self‐reported alcohol consumption, sociodemographic characteristics, AUD diagnosis, treatment status, SHG meeting attendance, membership duration, psychological distress, and health‐related variables. Of 6478 SHG members, 2955 (male: n = 2678; female: n = 277; response rate: 46.7%) responded, and the responses were analyzed using a gender‐stratified multivariate logistic regression model.ResultsMost participants reported having abstained from alcohol use, while 6% of the respondents reported having consumed alcohol during the early stages of the pandemic. The proportion of “drinkers” among women (10.5%) was significantly higher than that among men (5.9%; p = 0.012). Through multivariate model analysis, the factors associated with drinking during the pandemic were identified as psychological distress (among men and women) and not attending onsite recovery meetings (among men). Conversely, a longer duration of SHG membership was associated with less drinking during the pandemic for both genders.ConclusionsMost SHG members appear to have remained abstinent during the early stages of the COVID‐19 pandemic. However, psychological distress in both genders and the inability to attend recovery meetings among men may have influenced drinking behavior.
Effects of vitamin D on sex steroids, luteinizing hormone, and testosterone to luteinizing hormone ratio in 307 infertile men
Authors: Holt Rune , Yahyavi Sam Kafai , Kooij Ireen , Poulsen Nadia Nicholine , Juul Anders , Jørgensen Niels , Blomberg Jensen Martin 
Published: August 2023

AbstractObjectiveVitamin D status has been associated with sex steroid production. The question is whether vitamin D supplementation has an impact on sex steroid production in infertile men with vitamin D insufficiency?DesignA single‐center, double‐blinded, randomized clinical trial. Differences in sex steroids and reproductive hormones were predefined secondary outcomes, vitamin D status at baseline was a predefined subgroup and the primary outcome was differences in semen quality.MethodsA total of 307 infertile men were included and randomized 1:1 to active or placebo treatment for 150 days. Men in the active group initially received an oral bolus of 300,000 IU cholecalciferol, followed by daily supplementation with 1400 IU cholecalciferol and 500 mg calcium.ResultsAfter intervention, no differences were found in serum concentrations of sex steroids, luteinizing hormone, testosterone/luteinizing hormone ratio or SHBG between the vitamin D and placebo group. However, in a predefined subgroup analysis of men with serum 25OHD ≤ 50 nmol/L, men treated with vitamin D had a significantly higher testosterone/luteinizing hormone ratio [4.2 (3.8–4.4) vs. 3.7 (3.4–4.0); p = 0.033] compared with placebo treatment. In men with vitamin D deficiency, the difference between groups was larger but not significant due to few men with serum 25OHD < 25 nmol/L.ConclusionVitamin D + calcium supplementation did not alter sex steroid production in infertile men. However, vitamin D insufficient men treated with vitamin D supplementation had a significantly higher testosterone/LH ratio compared with placebo‐treated men, suggesting that optimal Leydig cell function are dependent on adequate vitamin D status.
Addition of a liver to the normothermic perfusion circuit reduces renal pro‐inflammatory factors
Authors: Li Fangcong , Zhang Yimin , Ruan Hehuan , He Yu , Zhan Liqiang , Chen Shirui , Wang Tielong , Qiu Jiang , Guo Zhiyong , Wang Dongping , He Xiaoshun 
Published: August 2023

AbstractBackgroundNormothermic machine perfusion (NMP) provides a novel platform to preserve isolated organs in an artificial condition. Our study aimed to explore the interaction between the liver and kidney at an ex vivo organ level by adding a liver to the kidney NMP circuit.MethodsPorcine kidney and liver obtained from abattoir were subjected to 9 h NMP after suffering 30‐min warm ischemia time and 90‐min cold ischemia time. The liver–kidney NMP group (n = 5) and the single‐kidney NMP group (n = 5) were designed. During the NMP, perfusion parameters, blood gas analysis, and tissue samples were compared.ResultsThe perfusate of both groups remained stable, and continuous urine production was observed during NMP. In the liver–kidney NMP group, the lactate level was low, while blood urea nitrogen increased and glucose levels decreased. After the NMP, the renal tissue in the liver–kidney group exhibited fewer histological changes such as tubular epithelium vacuolization, along with reduced expression of IL‐6, IL‐8, IL‐1β, NLRP3, and GSDMD.ConclusionsOur results indicated that the expression of renal pro‐inflammatory factors was reduced in the liver–kidney NMP system.
Inhibition of cystathionine‐gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles
Authors: Peleli Maria , Lyngso Kristina S. , Poulsen Frantz Rom , Hansen Pernille B. L. , Papapetropoulos Andreas , Stubbe Jane 
Published: August 2023

AbstractAimIn extracerebral vascular beds cystathionine‐gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H2S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in the intracerebral arterioles.MethodsIntracerebral arterioles were isolated from wild type C57BL/6J mouse (9–12 months old) brains and from human brain biopsies. The function (contractility and secondary dilatation) of the intracerebral arterioles was tested ex vivo by pressure myography using a perfusion set‐up. Reverse transcription polymerase chain reaction was used for detecting CSE expression.ResultsCSE is expressed in human and mouse intracerebral arterioles. CSE inhibition with L‐propargylglycine (PAG) significantly dampened the K+‐induced vasoconstriction in intracerebral arterioles of both species (% of maximum contraction: in human control: 45.4 ± 2.7 versus PAG: 27 ± 5.2 and in mouse control: 50 ± 1.5 versus PAG: 33 ± 5.2) but did not affect the secondary dilatation. This effect of PAG was significantly reversed by the H2S donor sodium hydrosulfide (NaSH) in human (PAG + NaSH: 38.8 ± 7.2) and mouse (PAG + NaSH: 41.7 ± 3.1) arterioles, respectively. The endothelial NO synthase (eNOS) inhibitor, Nω‐Nitro‐l‐arginine methyl ester (L‐NAME), and the inhibitor of soluble guanylate cyclase (sGC), 1H‐[1,2,4]oxadiazolo[4,3‐a]quinoxalin‐1‐one (ODQ) reversed the effect of PAG on the K+‐induced vasoconstriction in the mouse arterioles and attenuated the K+‐induced secondary dilatation significantly.ConclusionCSE contributes to the K+‐induced vasoconstriction via a mechanism involving H2S, eNOS, and sGC whereas the secondary dilatation is regulated by eNOS and sGC but not by CSE.
Influence of the COVID‐19 pandemic on prenatal and postpartum patient experiences and well‐being
Authors: Riggan Kirsten A. , Weaver Amy L. , Ashby Grayson , Huang Lily , Long Margaret E. , Torbenson Vanessa E. , Wick Myra J. , Allyse Megan A. , Rivera‐Chiauzzi Enid Y. 
Published: August 2023

AbstractBackgroundIt has yet to be fully elucidated how differing populations of obstetric patients adapted to the disruptions in perinatal care and postpartum support from the COVID‐19 pandemic. We surveyed an enriched sample of socioeconomically advantaged patients to understand the influence of COVID‐19 on their perinatal care experience, well‐being, and coping.MethodsWe surveyed pregnant and postpartum patients (n = 6140) at a large academic medical center in the Midwest of the United States using the Coronavirus and Perinatal Experiences instrument in Spring 2021.ResultsThe survey was sent to 6141 pregnant and postpartum patients; 1180 (17.8%) respondents completed the survey, including 256 who were pregnant and 834 postpartum. Most pregnant patients experienced no changes in their prenatal care with 16.5% indicating somewhat worsened care. In the postpartum cohort, 37.5% stated their care had somewhat worsened. In describing influences on stress and mental health, 58.1% of postpartum respondents stated it was moderately, and 17.4% significantly, worse. The pandemic had a somewhat or moderately negative influence for 72.7% of respondents, with 11.0% stating these effects were extremely negative. Both cohorts characterized a range of coping strategies, most commonly, talking with friends and family (76.3%).Conclusion(s)Even among this sample of socioeconomically advantaged patients, respondents indicated that the pandemic disrupted many facets of their medical care and daily life, especially social activities and postpartum support. Our findings suggest that counseling on coping and adaptation strategies for stressors and increased health systems support be part of perinatal care during public health emergencies for all demographic groups.
Orexin 2 receptor antagonism sex‐dependently improves sleep/wakefulness and cognitive performance in tau transgenic mice
Authors: Keenan Ryan J. , Daykin Heather , Metha Jeremy , Cornthwaite‐Duncan Linda , Wright David K. , Clarke Kyra , Oberrauch Sara , Brian Maddison , Stephenson Sarah , Nowell Cameron J. , Allocca Giancarlo , Barnham Kevin J. , Hoyer Daniel , Jacobson Laura H. 
Published: August 2023

AbstractBackground and PurposeTau pathology contributes to a bidirectional relationship between sleep disruption and neurodegenerative disease. Tau transgenic rTg4510 mice model tauopathy symptoms, including sleep/wake disturbances, which manifest as marked hyperarousal. This phenotype can be prevented by early transgene suppression; however, whether hyperarousal can be rescued after onset is unknown.Experimental approachThree 8‐week experiments were conducted with wild‐type and rTg4510 mice after age of onset of hyperarousal (4.5 months): (1) Tau transgene suppression with doxycycline (200 ppm); (2) inactive phase rapid eye movement (REM) sleep enhancement with the dual orexin receptor antagonist suvorexant (50 mg·kg−1·day−1); or (3) Active phase non‐NREM (NREM) and REM sleep enhancement using the selective orexin 2 (OX2) receptor antagonist MK‐1064 (40 mg·kg−1·day−1). Sleep was assessed using polysomnography, cognition using the Barnes maze, and tau pathology using immunoblotting and/or immunohistochemistry.Key ResultsTau transgene suppression improved tauopathy and hippocampal‐dependent spatial memory, but did not modify hyperarousal. Pharmacological rescue of REM sleep deficits did not improve spatial memory or tau pathology. In contrast, normalising hyperarousal by increasing both NREM and REM sleep via OX2 receptor antagonism restored spatial memory, independently of tauopathy, but only in male rTg4510 mice. OX2 receptor antagonism induced only short‐lived hypnotic responses in female rTg4510 mice and did not improve spatial memory, indicating a tau‐ and sex‐dependent disruption of OX2 receptor signalling.Conclusions and ImplicationsPharmacologically reducing hyperarousal corrects tau‐induced sleep/wake and cognitive deficits. Tauopathy causes sex‐dependent disruptions of OX2 receptor signalling/function, which may have implications for choice of hypnotic therapeutics in tauopathies.
Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration
Authors: Westgate Connar Stanley James , Kamp‐Jensen Christina , Israelsen Ida Marchen Egerod , Toft‐Bertelsen Trine , Wardman Jonathan Henry , Jensen Christian Ahm , Styrishave Bjarne , MacAulay Nanna , Jensen Rigmor Højland , Eftekhari Sajedeh 
Published: August 2023

AbstractBackground and PurposeDiseases of raised intracranial pressure (ICP) cause severe morbidity and mortality. Multiple drugs are utilised to lower ICP including acetazolamide and topiramate. However, the evidence for their use is unclear. We aimed to assess the ICP modulatory effects and molecular effects at the choroid plexus (CP) of acetazolamide and topiramate.Experimental ApproachFemale rats were implanted with telemetric ICP probes for physiological, freely moving 24/7 ICP recordings. Randomised cross‐over studies were performed, where rats received acute (24 h) high doses of acetazolamide and topiramate, and chronic (10 days) clinically equivalent doses of acetazolamide and topiramate, all via oral gavage. Cerebrospinal fluid (CSF) secretion assays, and RT‐qPCR and western blots on in vitro and in vivo CP, were used to investigate drug actions.Key ResultsWe demonstrate that acetazolamide and topiramate achieved maximal ICP reduction within 120 min of administration, and in combination doubled the ICP reduction over a 24‐h period. Chronic administration of acetazolamide or topiramate lowered ICP by 25%. Topiramate decreased CSF secretion by 40%. Chronic topiramate increased the gene expression of Slc12a2 and Slc4a10 and protein expression of the sodium‐dependent chloride/bicarbonate exchanger (NCBE), whereas chronic acetazolamide did not affect the expression of assessed genes.Conclusions and ImplicationsAcetazolamide and topiramate are effective at lowering ICP at therapeutic levels. We provide the first evidence that topiramate lowers CSF secretion and that acetazolamide and topiramate may lower ICP via distinct molecular mechanisms. Thus, the combination of acetazolamide and topiramate may have utility for treating raised ICP.