bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinician perspectives, attitudes, and experiences with eye-movement desensitization and reprocessing therapy: A systematic review
Authors: Morrison Natalie May Virginia , Morrison Ben William , Mahlberg Justin 
Published: April 2023

Abstract
Eye Movement Desensitisation and Reprocessing (EMDR) therapy is considered a gold standard treatment for post-traumatic stress disorder and other mental health conditions underpinned by trauma exposure. Despite EMDR’s evidence-base it remains under prescribed. This systematic review examined clinician perceptions of, and experiences with, EMDR to elucidate the reasons for under prescription. A systematic search of PsycInfo, PsychArticles, Psychology Database, Medline, PubMed, CINAHL, Scopus, and Google Scholar was conducted to identify literature on clinician perceptions of, attitudes towards, and prescription behaviours for, EMDR therapy. Seven studies met criteria for inclusion, however following initial quality appraisal only five were retained. Collectively the quality of the research appeared to be of low-moderate standard. The participant samples were varied across mental health disciplines with the majority of clinicians practicing in the USA. Qualitative, quantitative, and mixed approaches were used. Themes highlighted pragmatic obstacles to EMDR prescription including knowledge limitations, training access issues, and minimal post-training support. Additional themes suggested clinicians are hesitant to train in new modalities and that EMDR clinicians may be exposed to workplace bullying and harassment. EMDR under prescription will need to be addressed using a combination of increased resources and education at the individual and workplace/discipline levels.
Blinding assessment of manual therapy interventions of the back in Swiss graduate students: a blinding feasibility randomized controlled trial
Authors: Laguna Javier Muñoz , Nyantakyi Emanuela , Bhattacharyya Urmila , Blum Kathrin , Delucchi Matteo , Klingebiel Felix Karl-Ludwig , Labarile Marco , Roggo Andrea , Weber Manuel , Radtke Thomas , Puhan Milo A , Hincapié Cesar A 
Published: April 2023

Abstract
Study design
Single center, two-parallel group, blinding feasibility randomized controlled trial.
Background
Clinical trials of manual therapy interventions for back pain face methodological challenges regarding blinding of assigned interventions. We assessed blinding of participants and outcome assessors in a methodological randomized trial of two manual therapy interventions of the back and explored factors influencing perceptions about intervention assignment.
Methods
In a doctoral-level Introduction to Epidemiology course on 7–8 November 2022, 24 healthy students were randomly allocated (1:1) to active or control manual therapy interventions. The active manual therapy group (n = 11) received soft tissue mobilization of the lumbar musculature. The control group (n = 13) performed deep breathing exercises while receiving light touch over the thoracic region. The primary outcome was blinding feasibility of study participants immediately after intervention, derived from a 5-point scale and measured by the Bang blinding index (Bang BI), with values ranging from − 1 (opposite guessing) to 1 (complete unblinding), with 0 indicating random guessing (50% correct). Secondary outcomes included blinding feasibility of outcome assessors and factors influencing perceptions about intervention assignment in participants and outcome assessors, explored via thematic analysis.
Results
24 participants were analyzed following an intention-to-treat approach. 55% of participants in the active manual therapy group correctly identified their group allocation beyond chance immediately after intervention (Bang BI: 0.55 [95% confidence interval (CI), 0.25 to 0.84]), and 8% did so in the control manual therapy group (0.08 [95% CI, -0.37 to 0.53]). Bang BIs in outcome assessors suggested adequate blinding, with indices of 0.09 (-0.12 to 0.30) and − 0.10 (-0.29 to 0.08) for perceived allocation of active and control manual therapy participants, respectively. Blinding estimates were limited due to imprecision and suboptimal generalizability to real-world clinical settings. Participants and outcome assessors reported varying factors related to perceived intervention arm allocation.
Conclusions
Our findings suggest that blinding of participants and outcome assessors immediately after a one-time manual therapy intervention is feasible in randomized controlled trial settings. Careful thinking and consideration of blinding in manual therapy intervention trials is warranted and needed.
Trial registration:
Retrospectively registered at ClinicalTrials.gov ― currently under Protocol Registration and Results System (PRS) review.
Three-dimensional semiconductor detector array ArcCHECK for radiation detection and quality assurance of medical linear acceleration
Authors: Deng Jia , Huang Yun , Liu Shengyan , Zhao Yaolin , Wu Xiangyang 
Published: April 2023

AbstractMonitoring the radiation is an integral aspect of the physical practice of linear accelerators used in medical facilities to identify and treat radiation exposure. It is challenging for conventional two-dimensional dose test methodologies to meet the testing requirements of the volumetric modulated arc therapy (VMAT) irradiation technology. This study aimed to analyze multiple dose variations and mechanical correctness in linac operation using the ArcCHECK phantom and verify the accuracy of the method to improve the efficiency and precision of accelerator radiation monitoring.
Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia in rats through inhibiting TXNIP/NLRP3 signaling pathway
Authors: Chen Yao , Li Han-Zhou , Yang Yan , Feng Lei , Yuan En-Ze , Liao Jia-Bao , Zhao Jie , Xin Xiao-Chi , Lv Shu-Quan , Fang Xi-Xing , Wen Wei-Bo , Cui Huan-Tian 
Published: April 2023

Abstract
Polygalasaponin F (PGSF), an oleanane triterpenoid saponin extracted from Polygala japonica, has been demonstrated with neuroprotective effect. However, the therapeutic effects and mechanism of PGSF on focal ischemia remain unknown. In this study, we first established a rat model of focal ischemia using middle cerebral artery occlusion (MCAO) to evaluate the therapeutic effect of PGSF intervention and to investigate the impact of PGSF on the thioredoxin-interacting protein/NOD-, LRR-, and pyrin domain-containing protein 3 (TXNIP/NLRP3) inflammatory pathway. Secondly, brain neuron cells were isolated, and the cells received oxygen-glucose deprivation/reoxygenation (OGD/R) culture to establish the cell injury model in vitro. The mechanism of PGSF on the TXNIP/NLRP3 pathway was further validated. Our results showed that PGSF treatment reduced neurological scores, brain tissue water content and infarct volume and ameliorated the pathological changes in cerebral cortex in MCAO-induced focal ischemia rats. The TNF-α, IL-1β and IL-6 levels decreased in MCAO-induced focal ischemia rats after PGSF treatment. Moreover, PGSF down-regulated the protein expressions of TXNIP, NLRP3, ASC, cleaved caspase-1, IL-1β, and IL-18 in MCAO-induced focal ischemia rats. Meanwhile, PGSF treatment reduced the levels of apoptosis, ROS, inflammatory cytokine and TXNIP/NLRP3 pathway-related proteins (TXNIP, NLRP3, ASC, cleaved caspase-1, IL-1β, and IL-18) in OGD/R-induced neuronal injury cells. Finally, PGSF treatment also inhibited the interaction between NLRP3 and TXNIP in vitro. In conclusion, our study demonstrated the therapeutic effects of PGSF on MCAO-induced focal ischemia rats. Moreover, the neuroprotective mechanism of PGSF on focal ischemia was associated with the inhibition of TXNIP/NLRP3 signaling pathway.
A proteomic analysis of human follicular fluid: proteomic profile associated with embryo quality
Authors: Ji Jingjuan , Zhu Xinyi , Zhang Yan , Shui Lijun , Bai Shun , Huang Lingli , Wang Haoyu , Luo Lihua , Xu Bo 
Published: April 2023

Abstract
Embryo selection is a key point of in vitro fertilization (IVF). The most commonly used method for embryo selection is morphological assessment. However, it is sometimes inaccurate. Follicular fluid (FF) contains a complex mixture of proteins that are essential for follicle development and oocyte maturation. Analyzing human FF proteomic profiles and identifying predictive biomarkers might be helpful for evaluating embryo quality. A total of 22 human FF samples were collected from 19 infertile women who underwent IVF/intracytoplasmic sperm injection (ICSI) treatment between October 2021 and November 2021. FFs were grouped into two categories on the basis of the day 3 embryo quality, grade Ⅰ or Ⅱ in the hqFF group and grade Ⅲ in the nhqFF group. FF was analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). The key differentially expressed proteins (DEPs) were validated by parallel reaction monitoring (PRM). Differentially expressed proteins were further analyzed using DAVID software. A total of 558 proteins were identified, of which 50 proteins were differentially expressed inthe hqFF vs. nhqFF group, including 32 upregulated proteins (>1.20-fold, P<0.05) and 18 downregulated proteins (<0.67-fold, P<0.05). Bioinformatics analyses showed that the upregulated DEPs were enriched in components of the coagulation and complement systems and negative regulation of peptidase activity, while the downregulated DEPs were enriched in molecular function of extracellular matrix structural and constituent collagen binding. Our results suggested that a number of protein biomarkers in FF were associated with embryo quality. It may help develop an effective and noninvasive method for embryo selection.
Incidence of lymph node metastasis from submucosa gastric cancer: A Retrospective Cohort Study in two centers
Authors: Yu Suyue , Mei Yu , Huang Jingyi , Gao Jianpeng , Feng Tienan , Yan Min , Zhu Zhenggang , Lu Aiguo , Zhu Zhenglun 
Published: April 2023

Abstract
Background. This paper investigates whether or not there are some preoperative predictors identifying lymph node metastasis (LNM) in patients with T1b gastric cancer and discusses the possibility of replacement by segmental gastrectomy (SG) or local gastrectomy (LG).
Methods. This study included patients with gastric cancer who underwent radical gastrectomy between January 2012 and December 2018, as well as those diagnosed with pT1b. Independent risk factors of lymph node metastasis were determined using univariate and multivariable logistics regression among clinicopathological characteristics. ROC curve was established to predict lymph node metastasis based on external data for validation.
Results. Among the 636 patients with pT1b gastric cancer as the internal training set, 168 (26.4%) had no lymph node metastasis. In addition, 3 cm or less in size (odds ratio [OR] 0.56, P<0.05), middle or upper portion (OR 0.64, P<0.05), differentiation (OR 0.40, P<0.001), without lymphatic-vascular invasion (LVI) (OR 0.39, P<0.001), and the negative status of HER2 (OR 0.46, P<0.005), were protective factors of LNM. A score was generated consisting of a middle portion and four other variables. ROC curve analysis on the external validation set revealed excellent discrimination as the area under the curve (AUC) was 0.815. The frequency of lymph node metastasis was 0% with all five protective factors.
Conclusions. Based on this retrospective study, T1b gastric cancer of the middle part of the stomach which is 3 cm or less in size, differentiated-type, negative HER2 status, and without lymphatic-vascular invasion might indicate pylorus-preserving gastrectomy due to lack of lymph node involvement.
Trial registration. The study is retrospectively registered.
AI-Based Betting Anomaly Detection System to Ensure Fairness in Sports and Prevent Illegal Gambling
Authors: Kim Changgyun , Park Jae-Hyeon , Lee Ji-Yong 
Published: April 2023

Abstract
This study develops a solution to sports match-fixing using various machine-learning models to detect match-fixing anomalies based on dividend yields. We use five models to distinguish between normal and abnormal matches: logistic regression (LR), random forest (RF), support vector machine (SVM), the k-nearest neighbor (KNN) classification, and the ensemble model, an optimized model of the previous four. The models classify normal and abnormal matches by learning their pattern with sports dividend yield data. The database was built on the world football league match betting data of 12 betting companies, with a vast collection of data on players, teams, game schedules, and league rankings for football matches. We develop an abnormal match detection model based on the data analysis results of each model, using the match result dividend data. Then, we use data from real-time matches and apply the five models to construct a system capable of detecting match-fixing in real-time. The RF, KNN, and ensemble models recorded a high accuracy of over 92%, whereas the LR and SVM models were approximately 80% accurate. By comparison, previous studies have used a single model to examine suspected matches using football match dividend yield data, with an accuracy of 70–80%.
Research on Flexible Workshop Scheduling Algorithm Based on Improved Genetic Algorithm
Authors: Feng Chao , Peng Xiaolin , Qin Hengfeng 
Published: April 2023

Abstract
With the proposal of "Made in China 2025", the manufacturing industry is rapidly integrating with information technology, accelerating the pace of construction of smart factories, and reducing labor costs by establishing factories with few people and no one.Scheduling algorithm of flexible shop is the key technology to realize automatic processing of production line. The limited resources of shop can be allocated rationally through scheduling algorithm to complete automatic production.According to the requirements of automatic production line, this chapter realizes the assignment of processing task and handling task in turn.The classical genetic algorithm is easy to fall into local optimization and slow convergence.An improved genetic algorithm is adopted to introduce dynamic crossover and mutation probability. In addition, when the algorithm performs crossover operation, the individuals are first sorted according to their fitness values, and then cross operation is carried out successively.Through the simulation experiment, it is found that the task completion time obtained by the improved algorithm is 146 units of time, compared with the 198 units of time obtained before the improvement, the task completion time is reduced by 26%, and the improved algorithm has better convergence speed, so the improved algorithm has better optimization performance.
Comprehensive analysis of the prognostic value of PEBP4 in pan-cancers
Authors: Wang Sidan , Luo Zhijun 
Published: April 2023

Abstract
Background PEBP4, a member of the protein family containing a binding motif for phosphatidylethanolamine, is involved in the development, progression, metastasis, and invasion of many cancers. However, a complete analysis of the predictive value of PEBP4 in diagnosis, prognosis, and immunotherapy has not been conducted. Therefore, this study aimed to evaluate the relationship between PEBP4 expression and pan-cancer prognosis, progression of multiple cancers, and immune cell infiltration into the tumor microenvironment.Methods In this study, transcriptomic data on PEBP4 expression in tumor tissues and normal or paraneoplastic tissues were obtained from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. Based on various analysis tools such as " Gene set variation analysis (GSVA)" and "CIBERSORT," we comprehensively analyzed PEBP4 expression differences, clinical features, survival prognosis, immune-related characteristics, and potential interaction targets in various tumors.Results The analysis of the expression of PEBP4 in 33 human cancers showed that PEBP4 expression was downregulated in most cancers and correlated with the pathological stage, grade, and prognosis of multiple cancers, suggesting that PEBP4 may play a role in regulating tumorigenesis and progression in multiple cancers. In addition, PEBP4 gene expression is associated with the infiltration of several immune cells and immune-related genes, and is related to Tumor Mutation Burden (TMB)/ Microsatellite Instability (MSI) in various cancers. These results indicated that PEBP4 is involved in the immune response of tumor cells to immunotherapy and could be a potential target for immunotherapy in various cancers.Conclusion This study identified PEBP4 as a potential biomarker for the diagnosis and prognosis of multiple cancers. It is closely associated with the regulation of the tumor immune microenvironment, which lays the groundwork for further functional and mechanistic experiments.
Computer vision techniques for anatomically inspired classification of the endangered rusty-patched bumble bee (Bombus affinis)
Authors: Bhuiyan Tanvir , Carney Ryan , Chellappan Sriram 
Published: April 2023

Abstract
Bombus affinis, commonly known as the rusty-patched bumble bee, is a critically endangered species endemic to North America. Accurate identification of this bee is crucial for monitoring its presence and abundance, and in turn conservation efforts. Here, we design computer vision techniques to identify the rusty-patched bumble bee from images uploaded by citizen scientists on the iNaturalist platform. Our original dataset consists of 200 images of the rusty-patched bumble bee, and 200 images of other bees across six genera. After image augmentation (mirror, rotate) to yield a final dataset of 3, 200 images, we fine-tuned an EfficientNetV2B0 AI model to classify the rusty-patched bumble bee, and were able to achieve accuracies of 90% and 92% for color and grayscale images. However, motivated by a unique V-shaped black band that is present on the thorax of the rusty-patched bumble bee, we implemented an anatomically inspired learning framework wherein we automatically extract and classify only the thorax pixels from an image. Our resulting thorax-only model yielded classification accuracies of 94−95% and sensitivity (recall) values of 95−99%, across color and grayscale versions of manually and AI-cropped thorax images (the improved results presumably coming from removing other sources of noise). Deployment of these techniques could be useful in the automatic and real-time identification of rusty-patched bumble bees, hence aiding their identification and conservation. Our models can be easily extended to other insects, and to more anatomically inspired learning methods for classifying insects in nature.
Comparison between Ligation and Cauterization of Hemorrhoidal Pedicle with Milligan-Morgan Hemorrhoidectomy
Authors: Shareef Seerwan Hama , Ameen Shorsh Hama Hussein , Ismaeel Diyaree Nihad , Ezzaddin Shaho Abdulrehman , Ameen Hoshang Azad 
Published: April 2023

Abstract
Background: Currently, several therapies are used for symptomatic hemorrhoidal disease with various degrees of accepted treatment modality, but information on long-term outcomes is limited.
Objectives: This study aimed to compare ligation and cauterization of hemorrhoidal pedicles with Milligan-Morgan hemorrhoidectomy.
Patients and methods: This prospective cohort study was conducted on 200 patients with symptomatic hemorrhoidal disease in Sulaimani Surgical Teaching Hospital from January 2014 to January 2021. Patients were divided into 2 groups of 100 patients each. Group A underwent ligation and cauterization, while group B underwent Milligan-Morgan hemorrhoidectomy. Then, postoperative pain, urinary retention, and bleeding were collected. Patients were followed up for one year and data were collected regarding incontinence, anal stenosis and recurrence.
Results: The mean age of patients was 37.19±9.7 years, and most were females. The most common symptom was mucosal prolapse, followed by bleeding per rectum, then discharge, pruritis, and perianal pain/discomfort. Patients in group A experienced less pain than those in group B. Regarding the postoperative complications, surgical site infection was the most common one in both groups (34%), followed by bleeding per rectum (26%), then urinary retention (20%), incontinence (15%), and recurrence (11%). In comparison, anal stenosis was only found in 3% of group B patients.
Conclusions: The ligation and cauterization technique was safer, less costly, less painful, and had lower postoperative complication rates compared to the Milligan-Morgan procedure for the treatment of hemorrhoids.
Fuzzy Logic-Based AVC Relay with Jaya Algorithm for Voltage Control of Distribution Network
Authors: abdelfatah Ahmed , Sarimuthu Charles 
Published: April 2023

Abstract
One of the important requirements in the electrical power system is to control the voltage levels at both the distribution and transmission levels to avoid overvoltage or undervoltage conditions. Transformers with mechanical on-load tap changer (OLTC) and switches have been considered the conventional voltage-control method in electrical power systems for decades. Due to the mechanical design of the OLTC, it has several disadvantages, such as poor response time, high loss rates, high maintenance cost, and the demand for frequent repair of mechanical parts. Controlling the voltage with frequent changes in tap position causes wear and tear in the transformer over time. Old systems use fuzzy logic to control the OLTC tap position without finding the optimal tap or minimizing the number of tap changes. This paper attempts to develop automatic voltage control (AVC) Relay based on Fuzzy Logic and Jaya Algorithm to minimize the number of tap change operations. The design structure of the system is presented, and the results that show its performance with and without the Jaya algorithm are also presented and discussed.
Diurnal convection resonating with gravity waves in a model ITCZ
Authors: Haerter Jan O , Fiévet Romain 
Published: April 2023

Abstract
Tropical convective rainfall is known to vary with the diurnal cycle, yet it is also influenced by large scale convergence. In a suite of idealized cloud-resolving numerical experiments, we mimic Earth's Hadley cell to probe the interactions between oscillations in rainfall inherent to the large-scale circulation and the rainfall oscillation caused by the convective diurnal cycle. The model tropics are thereby caricatured by a rectangular domain that is periodic in both the meridional and zonal dimensions. Surface temperature TS is spatially constant in the "zonal" direction and decreases when moving "meridionally" away from the model equator. We contrast temporally constant TS with a TS that varies harmonically in time. By design, a large scale circulation develops with an intrinsic mode of oscillation of period ω0~Ly, i.e., proportional to the meridional domain size Ly --- thus generally differing from the diurnal period of one day. Interestingly, the diurnal forcing by no means shapes the precipitation power spectrum. Rather, the intrinsic circulation period dominates the precipitation power spectrum for large and small domains. At intermediate 𝐿𝑦 ≈ 2, 000 km, where intrinsic frequencies approximately match the diurnal one, the diurnal period prevails, the intrinsic frequency is suppressed, and the precipitation amplitude is amplified. We explain the complex dynamics as a type of resonance using a highly simplified forced and kicked harmonic oscillator.