bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trilha mineral no ensino básico em Marituba, estado do Pará, região amazônica
Authors: Tenoro Erik , Nascimento Rosemery da Silva 
Published: January 2025

Este trabalho representa o experimento pedagógico que tem como objetivo facilitar o ensino em ciências ambientais na educação básica, usando conceitos de mineralogia, bem como a origem, uso, aplicação destes recursos minerais. O levantamento de dados desta pesquisa foi realizado no Município de Marituba, em Belém-Pará, usando como modelo a Escola Municipal Dom Calábria, a fim de elaborar um roteiro de uma trilha mineral para ensino de ciências ambientais com base nas observações e análises de materiais naturais que ocorrem dentro e nos arredores da escola, usando materiais pétreos de construção civil que possam ser descritos como pontos de destaque e estudo no roteiro da trilha mineral, ressaltando o contexto regional de geodiversidade, no qual a escola está inserida. Desta forma, no roteiro da trilha mineral educacional, são apresentados conceitos básicos da geologia regional, destacando rochas e minerais que são usados na trilha mineral. Estes conceitos básicos são apresentados na forma de uma cartilha digital disponibilizada, a princípio para a Escola Dom Calábria e posteriormente para outras escolas do Município de Marituba, esperamos como resultado motivar e potencializar o ensino e aprendizado em ciências ambientais, avançando na formação de um pensamento mais crítico e social sobre uso e aplicação dos recursos minerais com a divulgação do roteiro Trilha Mineral Educacional nas escolas da região por intermédio do site da escola piloto e dos professores participantes.
As representações sociais como estratégia para investigar o trabalho com educação ambiental no ensino básico
Authors: Oliveira Marta Jacinto de , Veiga Léia Aparecida , Scheer Marcia Aparecida Procópio 
Published: January 2025

Tendo como recorte temático as representações sociais e a educação ambiental, esta pesquisa objetivou investigar e discutir as representações sociais sobre água e meio ambiente. O estudo foi realizado com estudantes de uma turma do 6º ano do Ensino Fundamental II em uma escola pública de Foz do Iguaçu/PR, no ano de 2019. Para tanto foram realizados levantamentos junto a fontes secundárias (material bibliográfico e documental) e primárias (levantamentos das representações sociais sobre os termos meio ambiente e água junto aos estudantes). Verificou-se que os/as estudantes participantes do levantamento apresentaram, na sua maioria, a ideia de meio ambiente em uma perspectiva naturalista e antropocêntrica, e acerca do entendimento do termo água, predominaram as ideias naturalista e utilitarista. Conclui-se que nas aulas de Geografia e Educação Ambiental ainda há lacunas no trabalho com o par dialético sociedade-natureza, dificultando assim o entendimento em uma perspectiva mais globalizante dessa questão.
Interfaces entre educação ambiental e ensino de línguas: ações por meio do cordel “planeta clorofila”, de Manoel Cavalcante
Authors: Neto João Batista Sena , Saboia Andrey Luna 
Published: January 2025

Este artigo objetiva analisar ações de Educação Ambiental (EA) realizadas em uma turma do Ensino Fundamental - Anos Finais de uma escola pública rural, localizada no município de Ipanguaçu/RN, em que a Literatura de Cordel “Planeta Clorofila” do artista potiguar Manoel Cavalcante foi utilizada como estratégia metodológica. No âmbito teórico, a pesquisa foi subsidiada, principalmente, em Candido (2011), nas concepções de gêneros textuais de Marcuschi (2008) e nos estudos sobre EA de Carvalho (2012) e Reigota (2012). Os procedimentos metodológicos, assentados na pesquisa-ação de base qualitativa, foram divididos em três etapas: a primeira, voltada à construção do referencial teórico, buscando-se compreender a relação entre Educação Ambiental e Literatura. A segunda etapa, que correspondeu à execução de três momentos na escola. E a terceira, dedicada à interpretação e análise dos resultados observados. Foi possível apreender a capacidade interdisciplinar da Literatura para viabilizar na sala de aula de Língua Portuguesa uma discussão e conscientização a respeito do meio ambiente, de como esse é encarado e do que pode ser feito para uma efetivação de dinâmicas envolvendo responsabilidade social e sustentabilidade.
Proposta Pedagógica da EJA do Município de Irará-Bahia: Uma Atualização Necessária
Authors: Júnior José Mário Bispo Gonçalves , Silva Cristina Ferreira da , Jesus Adriana de 
Published: January 2025

Este estudo teve por objetivo relatar o processo de atualização da proposta pedagógica da Educação de Jovens e Adultos (EJA) no município de Irará- BA, motivado pelos desafios impostos pela pandemia da COVID-19.Metodologicamente, o trabalho envolveu encontros participativos com gestores, coordenadores, educadores, educandos e secretários escolares, utilizamos uma abordagem qualitativa e princípios fundamentados na pedagogia de Paulo Freire, tais como o diálogo e crítica para analisarmos as discussões. Os eixos de análise emergentes incluíram a alfabetização digital, a valorização dos saberes dos educandos, o fortalecimento do diálogo pedagógico, a inclusão e flexibilidade curricular, a adequação tecnológica com formação continuada e a reafirmação da EJA como um direito fundamental. A atualização reforçou a concepção de uma educação inclusiva e democrática, alinhada com as legislações vigentes e voltada para a transformação social e emancipação dos sujeitos. Conclui-se que a proposta pedagógica revisada atende às exigências contemporâneas, promovendo uma prática educativa que respeita a diversidade e promove a inclusão.
Endothelial dysfunction in patients exposed to cardiovascular risk factors
Authors: Carbonell Amiot Tania Delia , Montes de Oca Carmenaty Margarita , Bringues Segura Denise , Romero García Lázaro Ibrahim 
Published: January 2025

Introduction: Cardiovascular diseases are the leading cause of death globally. 90% of them derive from cardiovascular risk factors, the modification of which makes it possible to reverse their harmful consequences. Objective: Identify the presence of endothelial dysfunction in patients exposed to classic cardiovascular risk factors.Method: An observational, descriptive study of case series was carried out with a sample n=106 of patients exposed to classic cardiovascular risk factors, during the period January 2022 to January 2024, treated in a specialized cardiological prevention clinic, at the Cardiology Center. and Cardiovascular Surgery, “Saturnino Lora” Provincial Hospital, Santiago de Cuba. Results: The most altered endothelial function was vasomotor, the highest proportion was found in the group of sick patients, reaching 88.68%. The second most altered function of the vascular endothelium was the inflammatory response, which generally reached proportions of 79.24 and 76.42%. The increase in the intima-media thickness of the carotid artery above 0.8 mm has a strong association with the appearance of CVD (p=0.000; V=0.531), followed by the us CRP value (p=0.001 ; V=0.333).Conclusions: It is concluded that there is an association between the presence of a dysfunctional vascular endothelium and the appearance of cardiovascular disease, determined predominantly by an alteration of vasomotor function and the inflammatory response.
National and international tendencies in the formation of talkative abilities for the Promotion of Health
Authors: Rodríguez Pérez Yanet , Sixto Fuentes Sahely , Iglesias Iglesias Modesto Antonio , Abreu Carrete Berta , Gómez Guerra Diana Belkys 
Published: January 2025

Introduction: the development of the process of formation of talkative abilities for the promotion of health constitutes a necessity to complete the integral general doctor's social responsibility Objective: to determine the international and national tendencies in connection with the formation of talkative abilities for the promotion of health Methods: it was used as method rector the dialectical one. Of the theoretical level: the historical-logical, analytic-synthetic and the inductive-deductive one. As empiric method the documental revision. Results: as international tendencies they were in this investigation: scarce published works, little emphasis in talkative abilities, formal incorporation of the formation of talkative abilities in the curricula of the medicine schools, boarding of the talkative abilities with more emphasis in the communication in the doctor-patient relationship and not in the activities of promotion of health in the APS, reorientation of the formation of talkative abilities with focus of primary attention of health.. In Cuba, they were: limitations of the systematic and integral boarding of the formation of talkative abilities for the promotion of health, isolated treatment of the value of the talkative abilities for the promotion of health in the solution of problems in the primary attention of health, recognition of the value of the talkative abilities for the promotion of health in the solution of problems in the primary attention of health, inclusion of curricular strategies in study plans guided to the formation of necessary talkative abilities for the promotion of health in the APS ,necesidad of improvement of the didactic boarding of the talkative abilities in the educational strategies for years and subjects in the study plans
Berry production in Alberta: Accessing the market through agritourism
Authors: Tymczak Aleksandra 
Published: January 2025

Berry production in Alberta: Accessing the market through agritourism
Aleksandra Tymczak studies the berry industry – an expanding industry in Alberta’s agricultural system. Here, she highlights the growing agritourism industry in relation to the opportunities presented to berry producers. On average, it takes two years to get one’s product to market, and the hardest part of getting the product on the shelf is actually distribution. The costs of distribution are a significant challenge because the product must be brought into a warehouse, and producers must conduct distribution themselves until they have scaled up to a particular size. As a result, this restricts producers from selling only within their local areas, following the farmers’ market model. However, producers willing to expand may lack sufficient manpower or energy to sell at multiple farmers’ markets. Once a producer has scaled up beyond the farmers’ market model, they have to determine the product scale and number of retail stores they need. A producer needs to pursue a reasonable market in proportion to their scaling-up capabilities to avoid underachieving once in the retail market.
A novel approach to cancer chemotherapy
Authors: Ludueña Richard F 
Published: January 2025

A novel approach to cancer chemotherapy
Richard F. Ludueña, Professor Emeritus at the University of Texas Health San Antonio, discusses his innovative approach to cancer chemotherapy, which could significantly enhance its effectiveness. The fundamental limitation to cancer chemotherapy is that cancer cells are our own cells misbehaving. Chemotherapy targets a protein or process that the cancer requires to survive and grow, but normal cells require the same protein or process to survive and grow, limiting chemotherapy’s effectiveness. Also, cancer cells can mutate to become resistant. I propose a two-targeted approach that should harm only cells that require both targets. Most cancer cells fulfill these criteria, but most normal cells do not.
Predictive analytics in the era of big data
Authors: Zahavi Jacob 
Published: January 2025

Predictive analytics in the era of big data
Jacob Zahavi, from The Coller School of Management at Tel Aviv University, discusses the components of predictive analytics (PA) and the increasing complexity of PA problems in the world of Big Data. This is the era of Big Data. Big Data are datasets that are too large and complex to handle using traditional data-processing tools and software. Data nowadays comes in huge quantities (volume), in different forms (velocity), and in a multitude of formats (variety). Some also add ‘value’ to this list. While raw data doesn’t have a value of its own, it carries a lot of hidden information essential for decision-making. For example, in marketing, data reflects the characteristics of potential buyers; in healthcare, which symptoms affect certain diseases; in insurance, which customers are more prone to risk; in banking, which customers are more likely to return their loans; and more.
A novel approach to sampling microplastics
Authors: Brandon Jennifer , Verlinden Christopher 
Published: January 2025

A novel approach to sampling microplastics
Applied Ocean Sciences is creating a sensor that is faster, more efficient, and less expensive than current sampling methods and will be the first sensor to allow near real-time abundance measurements for microplastics in a water sample. Microplastics are turning up everywhere we look for them. Microplastics (plastic particles < 5mm) have been found in various parts of the environment, including the oceans, the atmosphere, soil, and sea ice. They’re also making their way into our food and water, appearing in seafood, fruits, vegetables, beer, soda, tea, sea salt, honey, and both tap and bottled water. Alarmingly, microplastics are also being found within the human body – detected in our blood, lungs, and stool – and even in the placenta and breastmilk, revealing that exposure begins at the earliest stages of development. While research on the effects of microplastics on human health is still relatively preliminary, the harmful impacts of chemicals associated with plastics are well-documented.
Carbon capture surface: CO2 removal technology
Authors: McDaniel Beth 
Published: January 2025

Carbon capture surface: CO2 removal technology
Beth McDaniel, JD, Partner President from Reactive Surfaces Ltd. LLP, introduces us to Carbon Capture Surfaces, a CO2 removal technology that checks all the boxes. In the urgent race to combat climate change, innovation in carbon dioxide removal (CDR) technologies is critical. Among the many solutions under development, Carbon Capture Surfaces (CCS) stands out as a cutting-edge approach that offers cost-efficient, scalable, and measurable CDR in what is called a Passive DAC (Direct Air Capture) system, being one that leverages biological processes and materials, and natural and sustainable energy sources. This article explores how CCS captures and sequesters CO2 and checks all the boxes for desired attributes that leading carbon credit registries such as Gold Standard, Verra, and the Climate Action Reserve seek in High-Value CDR offset credits.
Traditional Use of Chamomile Flowers (Matricariae flos) in Inflammatory-Associated Skin Disorders
Authors: Melnyk Natalia , Nyczka Aleksandra , Piwowarski Jakub P. , Granica Sebastian 
Published: January 2025

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Chamomile (Matricaria chamomilla L.) is one of the world's oldest, and best-documented Asteraceae family medicinal herbs. It is now a popular and widely used therapeutic plant material in folk and traditional medicine. The plant includes numerous components. More than 120 secondary metabolites were identified in it, including flavonoids, terpenoids, sesquiterpenes, coumarins, essential oils, and organic acids. Due to its rich chemical composition, chamomile has many beneficial properties. These include anti-inflammatory, antibacterial, antiseptic, antispasmodic, sedative, antitumor, antioxidant, hypoglycemic, hypotensive, anti-allergic, antidepressant, antianxiety, analgesic, antipruritic, antidiarrheal, hepatoprotective and neuroprotective effects. Chamomile's effectiveness in treating various skin issues is also attributed to its diverse bioactive components. The research delving into chamomile's therapeutic potential reveals that its historical use for skin conditions is not merely based on folklore, but is substantiated by the intricate interactions among its chemical constituents at the molecular level. The goal of this review is to synthesize existing knowledge about chamomile's traditional uses in the treatment of inflammatory skin disorders, with a focus on the findings reported in contemporary scientific literature by scanning PubMed and Scopus for research.
Evaluation of the effectiveness of platelet-rich plasma therapy in the treatment of osteoarthritis compared to other treatment methods
Authors: Makarewicz Magdalena , Łysiak Anna , Łysiak Katarzyna , Maziarz Barbara 
Published: January 2025

Introduction and objective: Osteoarthritis is a common condition affecting a large proportion of the population. It is associated with a significant reduction in quality of life due to pain and limited joint mobility. There are many methods of treatment, among them conservative methods, pharmacological or surgical treatment can be mentioned. This article analyzes the effectiveness of intra-articular injections of platelet-rich plasma compared to other methods.
The aim of the article is to characterize the disease which is osteoarthritis, draw attention to its etiology, diagnostic and especially to therapeutic possibilities.
Materials and methods: The article was based on scientific publications in the Pubmed database. The database was searched on July 28 2023 using the phrases 'osteoarthritis', ‘PRP’, ‘Platelet-rich plasma’. After reading the titles of found articles, 39 publications were selected. After the pre-analysis of the abstracts, 15 full-text works were selected to prepare the article.
Abbreviated description of the state of knowledge: Platelet-rich plasma is widely used in the treatment of osteoarthritis. There are many sources that prove its effectiveness in reducing pain, compared to injections of other substances, but there are also studies about the lack of sufficient evidence or the effect of prp similar to the placebo effect.
Summary: The use of platelet-rich plasma is a promising method of treating osteoarthritis, however, further research and long-term observations are needed to introduce this method to the standards of treatment.
Metabolite profiling, antioxidant, and in vitro wound healing activities of Citrus medica L. and Citrus x microcarpa Bunge peels and leaves essential oils
Authors: Husni Elidahanum , Hamidi Dachriyanus , Pavvellin Dean , Hidayah Hafizatul , Syafri Suryati 
Published: January 2025

Wound care is still dominated by the use of synthetic chemicals such as anti-inflammatory drugs, corticosteroids and antibiotics which have many shortcomings. One potential alternative to be developed is essential oils. Citrus are members of the Rutaceae family which contain essential oils. Citrus medica L. and Citrus x microcarpa Bunge are distributed in West Sumatra and research on wound healing activity is still lacking. Therefore, this study aims to identify the metabolite profiles of essential oils of two species of citrus using FTIR spectroscopy and GC-MS as well as evaluate their antioxidant activity and determine their wound healing activity. Essential oils were obtained by the hydrodistillation method. Metabolite fingerprinting and profiling were carried out by using FTIR and GC-MS methods. Antioxidant activity was determined using the ABTS and FRAP methods while wound healing used the MTT Assay and Scratch Assay. The result showed the secondary metabolites of Citrus medica peels (LPEO) and Citrus medica leaves (LLEO) essential oil contained D-limonene and citral. Meanwhile Citrus x microcarpa leaves (MLEO) contain β-pinene, germacrene D, and elemol and Citrus x microcarpa peels essential oil (MPEO) consists of D-limonene, β-pinene, and germacrene D. MLEO has stronger antioxidant activity than MPEO, LPEO and LPEO with ABTS and FRAP method with IC50 197.051 µg/mL and 8.04 Fe (II)/mg sample and is followed by LLEO. Testing of wound healing activity using MTT assay showed that MPEO significantly increased cell proliferation. Meanwhile, the highest wound closure was found at a concentration of 0.1 µg/mL for MLEO followed by LPEO at 77.54% and 73.71% using scratch assay method. It can be concluded that essential oils of Citrus medica and Citrus x microcarpa can increase cell proliferation and migration so that they have potential to be developed as an alternative in wound healing.
The effect of ethyl acetate fraction of Vernonia amygdalina Del. leaves on uric acid levels of male white mice (Mus musculus) hyperuricemia
Authors: Azzahra Rafifah , Arifin Helmi , Juwita Dian Ayu 
Published: January 2025

Hyperuricemia is a condition where uric acid levels in the blood are increased above normal. High levels of uric acid in the blood can cause a buildup of uric acid crystals in the joints and other organs of the body. One of the plants used as traditional medicine to reduce uric acid levels in the blood is Vernonia amygdalina Del. plant. This study aims to determine the effect of ethyl acetate fraction of V. amygdalina on uric acid levels of hyperuricemic male white mice. The experimental animals used were 54 male white mice which were divided into 6 groups, namely the negative control group, the positive control group, the comparison group, the 12.5 mg/kgBW dose treatment group, the 25 mg/kgBW treatment group, and the 50 mg/kgBW doses treatment group with a treatment duration of 5 days, 10 days and 15 days. Data analysis used two-way analysis of variance (ANOVA) followed by Duncan's Post Hoc test with 95% confidence intervals (P<0.05). The results obtained showed that uric acid levels decreased along with the length of time the ethyl acetate fraction was administered with the optimal reduction effect at a dose of 50 mg/kgBW. This study shows that the ethyl acetate fraction of V. amygdalina exhibits antihyperuricemic activity and can be used as an alternative medicine in the community.
Molecular docking, bioactivity, adme, toxicity risks, and quantum mechanical parameters of some 1,2-dihydroquinoline derivatives were calculated theoretically for investigation of its use as a pharmaceutical active ingredient in the treatment of multiple sclerosis (MS)
Authors: Islamoğlu Fatih 
Published: January 2025

In this study, some 1,2-dihydroquinoline derivatives, which have not been synthesized before, were designed, and their usability in the treatment of multiple sclerosis (MS) was investigated. Firstly, a docking study was conducted between the designed molecules and the target proteins (3PP4, 6OBD, 7YXA, and 7TD4) that interact with drugs (International Nonproprietary Name (INN): Ocrelizumab, Alemtuzumab, and Siponimod) used in the treatment of MS. ADME (absorption, distribution, metabolism, and excretion) properties (Boiled Egg graph, bioavailability radar, physicochemical properties, lipophilicity, water solubility, pharmacokinetics, drug similarity, and medicinal chemistry) were analyzed. Bioactivity score, drug-likeness score, drug score, toxicity risks (mutagenic, tumorigenic, irritant, reproductive effective, fathead minnow LC50 (96 hours), daphnia magna LC50 (48 hours), oral rat LD50), bioconcentration factor, and density values were calculated. Quantum mechanical parameters include highest occupied molecular orbital energy (EHOMO), lowest unoccupied molecular orbital energy (ELUMO), chemical potential (μ), electron affinity (EA), global softness (S), global hardness (η), ionization potential (IP), total energy, dipole moments, and electrophilicity (ω) values were also calculated for all molecules. As a result of the data obtained from all these studies, (7-(diethylamino)-1,2-dihydroquinolin-3-yl)(6-(diethylamino)-2,3-dihydro-1H-indazol-1-yl)methanone was determined to be the most ideal molecule that can be used as a pharmaceutical active ingredient in the treatment of MS. Bond angles, bond lengths, Mulliken atomic charges, and molecular electrostatic potential (MEP) were calculated for this ideal molecule, and the structure of the molecule was explained in a multifaceted way.