bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of unilateral facial infiltrating lipomatosis: summary of medical and dental implications
Authors: Bode Dr. Ayoola , Aslam Dr. Fawad , O'Kane Dr. Donal , McIntosh Dr. Angela , Humphreys Dr. A. Karen 
Published: January 2025

Introduction Facial infiltrating lipomatosis (FIL) is a rare congenital and benign condition, resulting from mature nonencapsulated adipocytes penetrating into neighbouring structures. Individuals with FIL present with unilateral facial and craniofacial hemihypertrophy, alongside various medical and dental complications of the affected side. Case report At birth, the infant had an evident right sided facial swelling which remained asymptomatic but continued to increase in size. Magnetic resonance imaging confirmed right-sided lipomatous hyperplasia and genetic testing confirmed a somatic mutation to PIK3CA; the cause of cell hyperproliferation, often identified in FIL cases. On the right side, the child has developed epidermal naevus and mild hearing and visual impairment. A multidisciplinary team (paediatric medicine and dentistry, dermatology, ENT and plastics at Great Ormond Street Hospital) has contributed to managing the complex condition. At 12 months old, paediatric dentistry observed premature eruption of teeth 53, 54 and 84 and hyperplasia of the upper right alveolar arch. At 5 years-old, the child presented with premature exfoliation of primary teeth and premature eruption of permanent teeth 14, 16, 41, 42 and 46 with bilateral crossbites. Management A dental prevention regime has been implemented and the child remains caries free. The developing dentition will continue to be monitored with consideration of orthodontic management. Presently, as the child remains stable, a conservative approach without surgical or medical intervention has been adopted. His vision is corrected with glasses. Conclusion FIL is associated with dental developmental anomalies and medical complications of the affected side, requiring multidisciplinary care.
BPCA as a Model for Government-Sponsored Drug Repurposing
Authors: Kesselheim Aaron , Liu Ian 
Published: January 2025

Drug repurposing can include the application of previously approved prescription drugs to new medical conditions and has been proposed as a lower-cost and less-risky approach to developing useful new treatments for patients, since widespread experience with a drug can help provide signals of potential activity and safety profile. There have been numerous examples of successful drug repurposing, such as thalidomide for multiple myeloma and colchicine for cardiovascular disease.
Despite the promise of the idea, there is concern that drug repurposing is under-used. Explanations include that drug repurposing provides little financial incentive for manufacturers to pursue such development,
1 especially compared to the potentially lucrative market exclusivities associated with bringing new products to market.
One solution to help stimulate greater repurposing could be public funding of necessary clinical trials, such as through the National Institutes of Health (NIH). A successful legislative model for running such studies is the 409(i) provision of the Best Pharmaceuticals for Children Act (BPCA).
Optimasi Sosial Media Marketing dengan Brand Equity untuk Meningkatkan Customer Willingness to Pay for Premium Property pada Citraland City CPI
Authors: Wijaya Cynthia , Ardyan E. Elia , Gatot Haryono Cosmas 
Published: January 2025

Pembelian properti memerlukan keputusan yang kompleks dan konsumen cenderung melakukan pencarian informasi yang panjang. Sosial media marketing merupakan salah satu strategi efektif yang dapat digunakan untuk memberikan informasi dan berkomunikasi dengan konsumen. Persepsi dan pola pikir baik atas suatu brand mampu meningkatkan keinginan konsumen untuk membayar lebih. Penelitian ini bertujuan melihat pengaruh mediasi Branding Equity (BE) dalam sosial media marketing (SMM) serta pengaruhnya terhadap customer Willingness To Pay (WTP) pada Citraland City CPI. Penelitian menggunakan metode kuantitatif dengan pengumpulan data melalui kuesioner yang disebarkan kepada pemilik unit di CitraLand City CPI. Analisis data dilakukan dengan metode SEM-PLS. Hasil penelitian menunjukkan bahwa variabel SMM memengaruhi WTP dengan nilai R-square 0,852 (85,2%), sementara variabel BE dipengaruhi oleh SMM dengan nilai R-square 0,790 (79%). Hubungan langsung antara SMM dan WTP memiliki koefisien jalur sebesar 0,646 dengan t-statistik 4,682. Hubungan SMM terhadap BE memiliki koefisien jalur sebesar 0,889, sedangkan hubungan BE terhadap WTP memiliki koefisien 0,299. Mediasi BE memperkuat hubungan SMM terhadap WTP dengan koefisien 0,266. Seluruh variabel memiliki hubungan signifikan. Brand Equity sebagai variable mediator terbuksi mampu memperkuat hubungan antara sosial media marketing dan keinginan konsumen untuk membayar properti premium. Kesimpulannya, BE berperan penting sebagai mediator dalam memperkuat efek SMM terhadap WTP untuk properti premium. Strategi pemasaran melalui media sosial yang optimal dapat meningkatkan persepsi konsumen terhadap nilai merek, mendorong kesediaan mereka membayar harga premium. Implikasi penelitian ini membuka peluang pengembangan strategi pemasaran berbasis media sosial yang lebih efektif untuk produk high involvement, seperti properti premium.
Determinasi Minat Beli Ulang Produk Skincare Avoskin: Perspektif Influencer, Citra Merek Dan Kepercayaan Merek
Authors: Yuniawaty Yunni , Istichanah Istichanah 
Published: January 2025

In the current digital era, the beauty industry is experiencing rapid growth. Increasingly fierce competition encourages companies to implement various innovative marketing strategies. One popular strategy is to utilize the influence of influencers to promote products. Apart from that, brand image and consumer trust are also important factors that can influence purchasing decisions. This research aims to determine and analyze the influence of influencers, brand image and brand trust partially and simultaneously on interest in repurchasing Avoskin skincare products. The analysis method in this research is to use primary data taken from distributing questionnaires to 90 respondents who are students at Gunadarma University, Faculty of Economics, Management Study Program Class of 2024 who have purchased Avoskin skincare products at least once. The data collection method used was an online questionnaire via Google Form. The analytical tools used are data instrument tests, normality tests, classical assumption tests, multiple linear regression tests, hypothesis tests and coefficient of determination (R2) tests using the SPSS application. The research results show that the influencer variable partially has no effect on interest in repurchasing Avoskin skincare products. Meanwhile, brand image and brand trust variables partially influence interest in repurchasing Avoskin skincare products. Influencer variables, brand image and brand trust simultaneously influence interest in repurchasing Avoskin skincare products.
Plutocracy 2025
Authors: Zinnbauer Dieter 
Published: January 2025

When thinking about this current moment in time when major currents of political and economic power seem to flow into each other in exceptional and perhaps unparalleled ways, it might be useful to tease out in some more detail how exactly plutocracy 2025 differs from the entanglements of economic and business power that have come before. Here is one difference that seems particularly striking. Plutocracy in 2025, unlike its typical predecessors, is not really engineered in discrete fashion behind the scenes by deep-rooted dynasties of political and economic life. Instead, it is a full-frontal brash attack right on the public stage.
Speciation and Fluconazole Susceptibility of Candida Isolates from Clinical Samples in a Tertiary Hospital in Nepal
Authors: Sapkota Jyotshna , Aryal Kiran , Adhikari Ram Prasad , Khadka Sushila , Pandey Ritu , Khanal Laxmi Kant , Shrestha Deepti , Sharma Manisha 
Published: January 2025

IntroductionCandida species, commonly present as human commensals, are notable opportunistic pathogens responsible for superficial and invasive infections, particularly in hospitalized patients. This study aimed to characterize the distribution and antifungal susceptibility patterns of Candida species isolated from various clinical specimens at a tertiary care hospital in Nepal.
MethodsA descriptive cross-sectional, laboratory-based study was conducted in the Clinical Microbiology Laboratory of Nepal Medical College Teaching Hospital between July 2023 and June 2024. Clinical specimens yielding Candida species over the one-year period were included. Growth on Sabouraud dextrose agar was analyzed for colony morphology, Gram staining, germ tube production, and urea hydrolysis. Speciation of Candida isolates was performed using CHROMagar. Additionally, fluconazole susceptibility testing was conducted following Clinical and Laboratory Standards Institute guidelines.
ResultsA total of 72 Candida isolates were identified from samples such as sputum, urine, and high vaginal swabs. Candida albicans was the most prevalent species 45 (62.5%), followed by non-albicans Candida (NAC) species, including C. glabrata 14 (19.4%), 9 C. tropicalis (12.5%), and 4 C. parapsilosis (5.6%). Fluconazole resistance was observed in 35% of total isolates of Candida, with C. glabrata exhibiting the highest resistance 12, (86%), whereas 4 (9%) of C. albicans demonstrated resistance to it.
ConclusionThe findings highlight a shift in epidemiology toward NAC species and raise concerns about rising fluconazole resistance. These results underscore the need for routine species identification and antifungal susceptibility testing to guide effective management strategies. The study advocates for antifungal stewardship programs and ongoing surveillance to address emerging resistance trends in Candida infections.
Correlation of Cervical Pap Smear with Cervical Biopsy in Lesions of Cervix
Authors: Tiwari Archana , Khanal Anupa , Sapkota Pratima , Karki Asmita 
Published: January 2025

Introduction Cervical cancer is the leading cause of mortality for women in underdeveloped nations and the 4th leading cause globally. Pap smears are non-invasive method, but are unable to pinpoint their location. However, cervical biopsies are an invasive but gold standard procedure.
Methods An analysis of all pap smears obtained during a one-year period, from April 14, 2022 to April 12, 2023 was carried out in the Department of Pathology, LMC, Palpa. But only the cases that had undergone both pap smear and cervical biopsy were compared. Only 64 of the 337 pap smears that were obtained for cytological analysis also had a biopsy.
Results Out of 64 pap smear, 32.81% had normal cytology, 25% had ASC-US, 4.68% had atypical glandular cells, and 9.37% had HSIL. The most pap smears were done on people between the ages of 31 and 40. In 64 biopsies, 23 (35.93%) had HSIL, 20 (31.25%) had LSIL, and 7 (10.93%) had chronic cervicitis, according to the histological diagnosis of biopsies. Four individuals had a cancer diagnosis, including two (3.12%) squamous cell carcinomas and two (3.12%) adenocarcinomas. The Pap smear showed a sensitivity of 25.92%, specificity of 94.59%, PPV of 77.77%, NPV of 63.63%, and a diagnostic accuracy of 65.62%.
Conclusion The Pap smear test, had poor sensitivity but good specificity in detecting premalignant and malignant cervical abnormalities. Pap smear is a noninvasive method; however, cervical biopsy is a gold standard but invasive technique.
Inovasi Media Pembelajaran Quizpard Pada Pembelajaran PPKn Kelas X-6 Di SMAN 11 Medan T.P. 2024/2025
Authors: Ayuwulandari  , Susilawaty Evi , Nur Juwita Fauziah 
Published: January 2025

Pada penelitian ini penulis meneliti dua media interaktif web yang bersifat digital adalah quizizz dan nearpad sebagai sarana untuk menarik dan mendesain pembelajaran Fokus penelitian ini penulis amati judul penelitian Memanfaatkan Media Web Nearpad dan Quizizz Dalm Pembelajaran PPKn di Kelas X-6 Di SMAN 11 Medan, Tahun pelajaran 2024/2025. Peneltian QuizPard adalah model inovasi terbaru diera teknologi masa kini didalam pembelajaran Quizpard perpaduan antara Quizizz dan Nearpad yang menyatukan sarana agar pembelajaran PPKn tidak berisfat menonton dan disesuaikan dengan perkembangan kemajuan teknologi. Media QuizPard lebih ke arah sesuai tuntutan zaman sekarang yang kreatif, inovatif dan terampil. Penelitian ini penulis gunakan metode kualitatif, jumlah responden 36 peserta didik. Alasan penulis gunakan metode kualitatif adalah teknik deskripsi investigasi yang menjelaskan atau menjelaskan suatu masalah. Studi deskriptif bertujuan untuk menjelaskan populasi, situasi, atau fenomena secara akurat dan sistematis.
Қазақстанда балалардың әл-ауқаты индексін зерттеудің жекелеген аспектілері
Authors: Сатанов А.Б. , Әбішева Г.Ә. , Қадірова Ф.М. , Инербаева Қ.А. 
Published: January 2025

Балалар әл-ауқатының индексі Қазақстандағы балалардың жағдайын тұрақты және объективті негізде бақылап, көрсеткіштерге негізделген шешімдер қабылдауға мүмкіндік береді. Мақаланың зерттеу әдістемесі сандық және сапалық деректерді талдауға арналған пәнаралық тәсілге негізделіп, балалардың зияткерлік, эмоционалдық және физикалық әл-ауқатын бағалауға арналған. Зерттеудің мақсаты – Қазақстандағы балалардың зияткерлік, эмоционалдық және физикалық әл-ауқатының жай-күйін кешенді қарастыру. Балалардың әл-ауқатын қамтамасыз етуге қатысты практикалық ұсыныстар беріледі.
Индекс благополучия детей позволяет на постоянной и объективной основе контролировать состояние детей в Казахстане и принимать решения, основанные на показателях. Методология исследования статьи основана на междисциплинарном подходе к анализу количественных и качественных данных и предназначена для оценки интеллектуального, эмоционального и физического благополучия детей. Цель исследования – комплексное рассмотрение состояния интеллектуального, эмоционального и физического благополучия детей в Казахстане. Даются практические рекомендации по обеспечению благополучия детей.
The child well-being index allows for monitoring the condition of Kazakhstani children on a continuous and objective basis and making indicator-based decisions. The research methodology of the article is grounded on an interdisciplinary approach to analysing quantitative and qualitative data. It is designed to assess the intellectual, emotional and physical well-being of children. The purpose of the study is a comprehensive review of the state of intellectual, emotional and physical well-being of children in Kazakhstan. Practical recommendations are given to ensure children’s well-being.
School nutrition: a comprehensive programme to improve student wellbeing
Authors: Omarova K. , Malikov N. , Antayeva D. 
Published: January 2025

Improving student satisfaction with school meals is a key indicator of enhancing overall wellbeing within the school environment. This study evaluates the impact of a comprehensive, multi-component nutrition intervention implemented in Nazarbayev Intellectual Schools and the International School of Astana. The intervention included staff training, menu diversification, student nutrition education and cafeteria upgrades to improve service efficiency and meal presentation. A pre-and post-intervention analysis revealed a significant increase in student satisfaction, demonstrating the effectiveness of an integrated approach to increasing meal quality and fostering student wellbeing.
Повышение удовлетворённости учеников школьным питанием является ключевым показателем улучшения общего благополучия в школьной среде. В данном исследовании оценивается влияние комплексной многокомпонентной программы по питанию, реализованной в Назарбаев Интеллектуальных школах и Международной школе города Астаны. Программа включала в себя обучение персонала, разнообразие меню, обучение учеников правильному питанию и модернизацию столовой с целью повышения эффективности обслуживания и улучшения качества подачи блюд. Анализ, проведённый до и после реализации программы, показал значительное повышение уровня удовлетворённости учеников, что свидетельствует об эффективности комплексного подхода к повышению качества питания и улучшению благополучия учеников.
Оқушылардың мектептегі тамақтануға қанағаттану деңгейін жоғарылату мектептегі жалпы хал-ахуалды жақсартудың негізгі көрсеткіші болып табылады. Бұл зерттеуде Назарбаев Зияткерлік мектептері мен Астана қаласы Халықаралық мектебінде қолданысқа енгізілген көпкомпонентті кешенді тамақтану бағдарламасының нәтижелері бағаланады. Бағдарлама қызметкерлерді оқыту, мәзірді түрлендіру, оқушыларды дұрыс тамақтануға дағдыландыру, қызмет көрсету тиімділігін арттыру және тағамдарды ұсыну сапасын жақсарту мақсатында асхананы модернизациялау сияқты мәселелерді қамтыды. Бағдарламаны жүзеге асыруға дейін және жүзеге асырғаннан кейін жүргізілген талдау оқушылардың қанағаттану деңгейі жоғарылағанын байқатты, бұл тамақтану сапасын жоғарылатуға және оқушылардың хал-ахуалын жақсартуға бағытталған кешенді тәсілдеменің тиімділігін көрсетеді.
Цифровое благополучие учеников: влияние образовательных технологий
Authors: Сабанова К.В. 
Published: January 2025

В статье рассматривается проблема влияния образовательных технологий на психоэмоциональное состояние школьников в контексте цифрового благополучия на уроках информатики. Представлены результаты исследования, проведённого среди 120 учащихся 7–9-х классов, демонстрирующие взаимосвязь между использованием различных цифровых инструментов и психологическим комфортом обучающихся. Особое внимание уделено анализу эффективности внедрения системы «мягкого вхождения» в программирование, организации цифрового наставничества и применения геймифицированных элементов. Полученные данные могут быть использованы педагогами для создания психологически комфортной образовательной среды и повышения эффективности обучения информатике.
The article deals with the problem of the influence of educational technologies on the psychoemotional state of schoolchildren in the context of digital wellbeing in computer science lessons. The results of the research conducted among 120 students of 7–9th grades, demonstrating the relationship between the use of various digital tools and the psychological comfort of students, are presented. Particular attention is paid to the analysis of the effectiveness of introducing the system of “soft entry” into programming, organizing digital mentoring, and applying gamified elements. The obtained data can be used by teachers to create a psychologically comfortable educational environment and improve the effectiveness of computer science education.
Мақалада информатика сабағындағы цифрлық хал-ахуал тұрғысынан білім беру технологияларының оқушылардың психоэмоционалдық жағдайына әсері проблемасы қарастырылады. Ұсынылған жұмыста 7-9-сыныптарда оқитын 120 оқушының қатысуымен өткізіліп, әртүрлі цифрлық құралдарды қолдану мен оқушылардың психологиялық жайлылығы арасындағы байланысты қарастырған зерттеу нәтижелері ұсынылған. Программалауды үйренудегі «Жеңіл бастама» жүйесін енгізудің, цифрлық тәлімгерлікті ұйымдастырудың және геймификацияланған элементтерді қолданудың тиімділігін талдауға баса назар аударылады. Педагогтер мақалада ұсынылған деректерді психологиялық қолайлы білім беру ортасын қалыптастыру және информатика пәнін оқытудың тиімділігін арттыру үшін қолдана алады.
人工智能赋能金融学课程创新：理论、实践与展望Artificial Intelligence-Driven Innovation in Finance Courses: Theories, Practices, and Prospects
Authors: 马艳  
Published: January 2025

本文探讨了人工智能（AI）技术在金融学课程创新中的应用，旨在为高校金融学教学改革提供指导。随着AI技术的快速发展，金融行业正经历深刻变革，对复合型金融人才的需求愈发迫切。文章首先梳理了建构主义、行为主义、混合式学习和联接主义学习理论在AI赋能金融学课程中的应用，包括情境模拟、个性化辅导、程序教学、强化机制、在线与面对面教学结合以及知识图谱技术建立知识点联系等。实践路径上，提出了基于AI的个性化教学策略、智能互动式教学模式和虚拟仿真实验教学应用，通过数据分析定制学习路径、智能工具增强课堂互动以及虚拟环境提升实操能力。此外，文章还探讨了AI优化教学评价，通过多维度数据驱动的评价指标体系、自动化与实时化评价过程以及促进学生全面发展的评价导向，实现对学生学习情况的全面、科学评估。最后，文章总结了研究结论，并对未来研究方向进行了展望。通过本文的研究，期望为高校金融学教学改革提供有益参考，助力培养适应新时代需求的高素质金融人才。
This paper explores the application of artificial intelligence (AI) technology in innovating finance courses, aiming to provide guidance for teaching reform in finance education at colleges and universities. With the rapid development of AI technology, the financial industry is undergoing profound transformations, and the demand for multidisciplinary financial talents is becoming increasingly urgent. Firstly, the paper examines the application of constructivism, behaviorism, blended learning, and connectivism learning theories in AI-empowered finance courses. These include scenario simulation, personalized tutoring, programmed instruction, reinforcement mechanisms, the integration of online and face-to-face teaching, and the establishment of knowledge point connections through knowledge graph technology. In terms of practical approaches, the paper proposes AI-based personalized teaching strategies, intelligent interactive teaching models, and virtual simulation experimental teaching applications. These involve customizing learning paths through data analysis, enhancing classroom interaction with intelligent tools, and improving practical operation skills within virtual environments. Additionally, the paper explores the optimization of teaching evaluation through AI. This includes a multi-dimensional, data-driven evaluation index system, an automated and real-time evaluation process, and an evaluation framework aimed at fostering students’ all-round development, enabling comprehensive and scientific assessments of their learning outcomes. Finally, the paper summarizes the research findings and discusses future research directions. It is expected that the insights provided by this study will serve as a valuable reference for teaching reform in finance education, contributing to the cultivation of high-quality financial talents equipped to meet the demands of the new era.
An Investigation of the Determinants of Creative Attitude Among Students in University of Agriculture, Faisalabad
Authors: Parveen Shahida , Nasir Naina , Umm-e-Habiba  , Haider Jamil , Naz Nosheen 
Published: January 2025

Creative thinking was listed among the skills that are required for upcoming graduating students’ entry-level careers which become more important to global industries. The main objective of this research is to investigate the determinants of creativity towards learning and examine the factors influencing student’s reactivity, exam the role of teaching methodologies and learning environment in creative attitude development among students. The study was conducted in the district Faisalabad. Total sample size of this study was 160 students calculated through www.surveysystem.com. Using a proportional sampling 132 students from IAEERD and 28 students from institute of resource economics. Overall results showed that majorities (54.16%) of respondents were in middle age group and (14.16%) respondents between 21-30 years, majorities (55.83%) of the respondents were male and (44.16%) were female. From the student (48.33%) of respondents were studied in BSc Hons and (25.83%) respondents were studied in MSc Hons. While (18.83%) were studied in M.Phil.It is recommended that teachers duty and responsibility to involve students in practical sessions and training workshops and other learning activities. Students elaborating ideas and engaged them self in creative type work and assignments for learning. Creative activities help students reveal their creativity to write and produce as well as giving students ample chances to explore and understand value of writing.