bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensive English programme ecology: decolonizing ‘within the cracks’
Authors: Litzenberg Jason 
Published: March 2023

Abstract
Intensive English programmes (IEPs) are college and university units that provide international students with academic English instruction for the purpose of admission to the host institution. IEPs are colonial endeavours: they commodify and promote a language with a traceable colonial history that is reinforced through modern structures of knowledge distribution within higher education. Reliance on colonial architectures limits creativity and enforces hegemonic structures upon a field that tends to manifest more social justice orientations. This article argues that the position of IEPs allows them to contest their colonial nature through conscientious, incremental change. It considers the core activities of the IEP ecology (i.e. instruction, discipline, profession, business, and service), looking at how each facet may be utilized to enact a decolonial option. These interventions lend themselves to goals of decolonial projects by reducing bias and hegemony in how IEPs approach language and are positioned within the field and their host institution.
Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement
Authors: Mas-Peiro Silvia , Abplanalp Wesley T , Rasper Tina , Berkowitsch Alexander , Leistner David M , Dimmeler Stefanie , Zeiher Andreas M 
Published: March 2023

Abstract

Aims
Mosaic loss of Y chromosome (LOY) in blood cells is the most common acquired mutation, increases with age, and is related to cardiovascular disease. Loss of Y chromosome induces cardiac fibrosis in murine experiments mimicking the consequences of aortic valve stenosis, the prototypical age-related disease. Cardiac fibrosis is the major determinant of mortality even after transcatheter aortic valve replacement (TAVR). It was hypothesized that LOY affects long-term outcome in men undergoing TAVR.

Methods and results
Using digital PCR in DNA of peripheral blood cells, LOY (Y/X ratio) was assessed by targeting a 6 bp sequence difference between AMELX and AMELY genes using TaqMan. The genetic signature of monocytes lacking the Y chromosome was deciphered by scRNAseq. In 362 men with advanced aortic valve stenosis undergoing successful TAVR, LOY ranged from −4% to 83.4%, and was &gt;10% in 48% of patients. Three-year mortality increased with LOY. Receiver operating characteristic (ROC) curve analysis revealed an optimal cut-off of LOY &gt;17% to predict mortality. In multivariate analysis, LOY remained a significant (P &lt; 0.001) independent predictor of death during follow-up. scRNAseq disclosed a pro-fibrotic gene signature with LOY monocytes displaying increased expression of transforming growth factor (TGF) β-associated signaling, while expression of TGFβ-inhibiting pathways was down-regulated.

Conclusion
This is the first study to demonstrate that LOY in blood cells is associated with profoundly impaired long-term survival even after successful TAVR. Mechanistically, the pro-fibrotic gene signature sensitizing the patient-derived circulating LOY monocytes for the TGFβ signaling pathways supports a prominent role of cardiac fibrosis in contributing to the effects of LOY observed in men undergoing TAVR.
The impact of modifiable risk factors in the association between socioeconomic status and sudden cardiac death in a prospective cohort study: equal access to healthcare, unequal outcome
Authors: Warming Peder Emil , Ågesen Frederik Nybye , Lynge Thomas Hadberg , Garcia Rodrigue , Banner Jytte , Prescott Eva , Lange Theis , Jabbari Reza , Tfelt-Hansen Jacob 
Published: March 2023

AbstractAimsLow socioeconomic status is associated with all-cause mortality and cardiac risk factors. Furthermore, sudden cardiac death (SCD) is among the leading causes of death in the general population, and an identification of high-risk subgroups is needed. The aim of this study was to investigate the association between income and education level and incidence of SCD and to calculate the impact of modifiable mediating risk factors.Methods and resultsParticipants in the Copenhagen City Heart Study were followed up from 1993 to 2016. Sudden cardiac death was identified using high-quality death certificates, autopsy reports, discharge summaries, and national registry data. Hazard ratios were calculated using Cox proportional hazards regression, and adjusted cumulative incidences were predicted using cause-specific Cox models. Mediation analyses were performed using a marginal structural model approach. During 24 years of follow-up, 10 006 people participated, whereof 5514 died during the study period with 822 SCDs. Compared with long education, persons with elementary school level education had an SCD incidence rate ratio (IRR) of 2.48 [95% confidence interval (CI) 1.86–3.31], and low income was likewise associated with an SCD IRR of 2.34 (95% CI 1.85–2.96) compared with high income. In the association between education and SCD, the combined mediating effect of smoking, physical activity, and body mass index accounted for ∼20% of the risk differences.ConclusionWe observed an inverse association between both income and education and the risk of SCD, which was only in part explained by common cardiac risk factors, implying that further research into the competing causes of SCD is needed and stressing the importance of targeted preventive measures.
Quantifying a spectrum of clinical response in atrial tachyarrhythmias using spatiotemporal synchronization of electrograms
Authors: Ganesan Prasanth , Deb Brototo , Feng Ruibin , Rodrigo Miguel , Ruiperez-Campillo Samuel , Rogers Albert J , Clopton Paul , Wang Paul J , Zeemering Stef , Schotten Ulrich , Rappel Wouter-Jan , Narayan Sanjiv M 
Published: March 2023

Abstract

Aims
There is a clinical spectrum for atrial tachyarrhythmias wherein most patients with atrial tachycardia (AT) and some with atrial fibrillation (AF) respond to ablation, while others do not. It is undefined if this clinical spectrum has pathophysiological signatures. This study aims to test the hypothesis that the size of spatial regions showing repetitive synchronized electrogram (EGM) shapes over time reveals a spectrum from AT, to AF patients who respond acutely to ablation, to AF patients without acute response.

Methods and results
We studied n = 160 patients (35% women, 65.0 ± 10.4 years) of whom (i) n = 75 had AF terminated by ablation propensity matched to (ii) n = 75 without AF termination and (iii) n = 10 with AT. All patients had mapping by 64-pole baskets to identify areas of repetitive activity (REACT) to correlate unipolar EGMs in shape over time. Synchronized regions (REACT) were largest in AT, smaller in AF termination, and smallest in non-termination cohorts (0.63 ± 0.15, 0.37 ± 0.22, and 0.22 ± 0.18, P &lt; 0.001). Area under the curve for predicting AF termination in hold-out cohorts was 0.72 ± 0.03. Simulations showed that lower REACT represented greater variability in clinical EGM timing and shape. Unsupervised machine learning of REACT and extensive (50) clinical variables yielded four clusters of increasing risk for AF termination (P &lt; 0.01, χ2), which were more predictive than clinical profiles alone (P &lt; 0.001).

Conclusion
The area of synchronized EGMs within the atrium reveals a spectrum of clinical response in atrial tachyarrhythmias. These fundamental EGM properties, which do not reflect any predetermined mechanism or mapping technology, predict outcome and offer a platform to compare mapping tools and mechanisms between AF patient groups.
Failure to purge: population and individual inbreeding effects on fitness across generations of wild Impatiens capensis
Authors: Toczydlowski Rachel H , Waller Donald M 
Published: March 2023

Abstract
Inbreeding exposes deleterious recessive alleles in homozygotes, lowering fitness and generating inbreeding depression (ID). Both purging (via selection) and fixation (via drift) should reduce segregating deleterious mutations and ID in more inbred populations. These theoretical predictions are not well-tested in wild populations, which is concerning given purging/fixation have opposite fitness outcomes. We examined how individual- and population-level inbreeding and genomic heterozygosity affected maternal and progeny fitness within and among 12 wild populations of Impatiens capensis. We quantified maternal fitness in home sites, maternal multilocus heterozygosity (using 12,560 single-nucleotide polymorphisms), and lifetime fitness of selfed and predominantly outcrossed progeny in a common garden. These populations spanned a broad range of individual-level (fi = −0.17–0.98) and population-level inbreeding (FIS = 0.25–0.87). More inbred populations contained fewer polymorphic loci, less fecund mothers, and smaller progeny, suggesting higher fixed loads. However, despite appreciable ID (mean: 8.8 lethal equivalents per gamete), ID did not systematically decline in more inbred population. More heterozygous mothers were more fecund and produced fitter progeny in outcrossed populations, but this pattern unexpectedly reversed in highly inbred populations. These observations suggest that persistent overdominance or some other force acts to forestall purging and fixation in these populations.
First unraveling of the hidden and intricate evolutionary history of a bacterial group II intron family
Authors: LaRoche-Johnston Félix , Prattico Catherine , Monat Caroline , Hinse Olivier , Cousineau Benoit 
Published: March 2023

Abstract
Bacterial group II introns are large RNA enzymes that self-splice from primary transcripts. Following excision, they can invade various DNA target sites using RNA-based mobility pathways. As fast evolving retromobile elements, which move between genetic loci within and across species, their evolutionary history was proved difficult to study and infer. Here we identified several homologs of Ll.LtrB, the model group II intron from Lactococcus lactis, and traced back their evolutionary relationship through phylogenetic analyses. Our data demonstrate that the Ll.LtrB homologs in Lactococci originate from a single and recent lateral transfer event of Ef.PcfG from Enterococcus faecalis. We also show that these introns disseminated in Lactococci following recurrent episodes of independent mobility events in conjunction with occurrences of lateral transfer. Our phylogenies identified additional lateral transfer events from the environmental clade of the more diverged Lactococci introns to a series of low-GC gram-positive bacterial species including E. faecalis. We also determined that functional intron adaptation occurred early in Lactococci following Ef.PcfG acquisition from E. faecalis and that two of the more diverged Ll.LtrB homologs remain proficient mobile elements despite the significant number of mutations acquired. This study describes the first comprehensive evolutionary history of a bacterial group II intron.
Paternal perspectives towards infant and young child feeding (IYCF): a qualitative analysis from Coastal South India
Authors: Mithra Prasanna , Unnikrishnan Bhaskaran , T Rekha , Kumar Nithin , Holla Ramesh , Rathi Priya 
Published: March 2023

Abstract

Background
The infant and young child feeding practices (IYCF) decide child growth and well-being. Paternal perspectives and involvement in IYCF are of paramount importance and are grossly under-studied.

Aims
To study the experiences and opinions of fathers of infants and young children towards feeding practices.

Settings and design
Two focus group discussions (FGD) were carried out in the community settings in Dakshina Kannada District, Karnataka State.

Methods and material
FGDs were carried out in the areas of two selected primary health centres. FGD guide was used and the discussions were audio recorded. Themes were derived from the transcript.

Results
Four main themes were generated from the transcripts of two FGDs. Lack of time to involve in child feeding, lack of felt need for increased involvement, sense of being complete in providing paternal care and readiness to learn were the generated themes. All participating fathers had favourable attitudes towards learning more about IYCF.

Conclusions
Lack of time felt need for higher paternal involvement in IYCF and sense of being complete in providing paternal care were the themes extracted, along with favourable attitude towards increasing their involvement in IYCF.
Geography shapes the microbial community inHeliconiusbutterflies
Authors: Luna Nicolás , Herrera Giovanny , Muñoz Marina , Sánchez-Herrera Melissa , Brown Anya , Khazan Emily , Pardo-Diaz Carolina , Ramírez Juan David , Salazar Camilo 
Published: March 2023

AbstractHeliconius butterflies are an ideal organism for studying ecology, behavior, adaptation, and speciation. These butterflies can be found in various locations and habitats in Central and South America, where they encounter and interact with different sources of pollen, nectar, and host plants. However, there is limited knowledge on how geographic and habitat variations affect the microbiota of these insects, and whether microbial associates play a role in their ability to exploit different habitats. To date, research on the microbial communities associated with Heliconius has mainly focused on host phylogenetic signal in microbiomes or microbiome characterization in specific communities of butterflies. In this study, we characterized the microbiomes of several species and populations of Heliconius from distant locations that represent contrasting environments. We found that the microbiota of different Heliconius species is taxonomically similar but vary in abundance. Notably, this variation is associated with a major geographic barrier—the Central Cordillera of Colombia. Additionally, we confirmed that this microbiota is not associated with pollen-feeding. Therefore, it seems likely that geography shapes the abundance of microbiota that the butterfly carries, but not the taxonomic diversity of the microbial community. Based on the current evidence, the bacterial microbiota associated with Heliconius does not appear to play a beneficial role for these butterflies.
Listeria monocytogenesfrom food and food industry environments with reduced susceptibility to benzalkonium chloride, sodium hypochlorite, and peracetic acid
Authors: Jaskulski Itiane Barcellos , Scheik Leticia Klein , Kleinubing Natalie , Haubert Louise , Kroning Isabela , Lopes Graciela Völz , Silva Wladimir 
Published: March 2023

AbstractThe growing number of Listeria monocytogenes strains displaying increased tolerance to sanitizers widely applied in the food industry is becoming a problem. The aims of this study were to evaluate the susceptibility of L. monocytogenes isolates from food and food industry environments to sanitizers (benzalkonium chloride, sodium hypochlorite, peracetic acid, and chlorhexidine) and heavy metals (cadmium chloride), as well as to investigate the presence of the main genes related to efflux pumps. All 82 isolates showed reduced susceptibility to benzalkonium chloride (MIC from 16 to 128 µg mL−1), sodium hypochlorite (MIC of ≥ 2048 µg mL−1), and peracetic acid (MIC from 512 to ≥ 2048 µg mL−1), while 22 isolates showed reduced susceptibility to cadmium chloride (MIC &gt; 70 µg mL−1). Susceptibility to chlorhexidine was found (MIC from 2 to 16 µg mL−1). PCR-based analysis revealed that mdrl and lde genes were harbored by 14.6% (12/82) and 40.2% (33/82) of the isolates, respectively. This study demonstrates the presence of L. monocytogenes from food and food industry environments with reduced susceptibility to sanitizers commonly used in food processing environments, highlighting the importance of continuous monitoring of the tolerance profile of this microorganism to sanitizers, as well as the need for strict control of sanitation conditions in food industries.
Effect ofkuratsuki Kocuriaon sake brewing in differentkojiconditions
Authors: Yazaki Ayano , Nishida Hiromi 
Published: March 2023

AbstractKoji is made using steamed rice and a koji mold, which plays an essential role in sake brewing. We challenge to build a new sake brewing method using the kuratsuki bacteria that have inhabited each sake brewery. In this paper, effects of the kuratsuki Kocuria strain TGY1127_2 were estimated on sake brewing in different koji conditions. Sake was produced by incubation of a mixture solution of koji, water, and sake yeast (strain K1401) with and without the kuratsuki Kocuria TGY1127_2. The effects of the kuratsuki Kocuria on the taste of the sake differed among different koji. The kuratsuki Kocuria led to an increase in ethanol concentration. Additionally, the sugar content (Brix) and acidity of the sake increased in proportion to the amount of koji. These results strongly suggest that the kuratsuki Kocuria does not adversely affect the fermentation activity of the sake yeast. Thus, the kuratsuki Kocuria had different effects on the taste of sake among different koji but the fermentation activity of the sake yeast was maintained.
Development of Non-Timber Forest Product Industry in the Context of Trade Globalization: A Case Study in Wuyishan, China
Authors: Luo Yixuan , Feng Xiao 
Published: March 2023

AbstractWith the trend of trade globalization, developing countries have an indispensable role in the global value chain. In China, production and trade of forest products appear to be considerably sensitive in balancing industry development and ecological conservation. Simultaneously, increased trade in non-timber forest products (NTFPs) has merged as a new direction for sustainable forestry development. This study explores the effect of the NTFP trade globalization process on NTFP producer capital input using a dataset of 976 oolong tea producers in Wuyishan City, China, from 2008 to 2020. We ran pooled- ordinary least square regression and the results show that the trade globalization process of tea products is a driving force in oolong tea producer capital inputs in Wuyishan City, which increases with forest resources and producer scale. Additionally, our findings reveal that the local government implemented a fiscal policy to promote a sustainable composite model (SCM) in tea production, which includes terrace protection, organic fertilizers, tea-broadleaf symbiosis, and ecological water systems. Given structural growth in demand for tea products driven by trade globalization, the SCM promotion policy enhanced the quantity and quality of oolong tea products based on a harmonious coexistence with nature resulting in a mutually beneficial outcome for the government and producers.Study Implications: Results of our study provide evidence that NTFP trade globalization and diversification can promote the NTFP industry by increasing productive capital inputs by producers and innovatively summarize an environmentally benign solution for the adjustment of the production model of NTFPs. The scarcity of forestland and the social uses of forest resources require embedding sustainable governance into the development of the NTFP industry. With government support, the new model of sustainable NTFP production can serve the long-term planning of rational forest resource use.
Age Differences in Motivated Cognition: A Meta-Analysis
Authors: Swirsky Liyana T , Sparrow Erika P , Sullivan Margot D , Valenzano Sabrina L , Chowdhury Sadia , Spaniol Julia 
Published: March 2023

Abstract

Objectives
The goal of this preregistered study was to synthesize empirical findings on age differences in motivated cognition using a meta-analytic approach, with a focus on the domains of cognitive control and episodic memory.

Methods
A systematic search of articles published before July 2022 yielded 27 studies of cognitive control (N = 1,908) and 73 studies of memory (N = 5,837). Studies had to include healthy younger and older adults, a within-subjects or between-subjects comparison of motivation (high vs low), and a measure of cognitive control or memory. The Age × Motivation effect size was meta-analyzed using random-effects models, and moderators were examined using meta-regressions and subgroup analyses.

Results
Overall, the Age × Motivation interaction was not significant in either cognitive domain, but the effect sizes in both domains were significantly heterogeneous, indicating a possible role of moderating factors in accounting for effect size differences. Moderator analyses revealed significant moderation by incentive type for episodic memory, but not for cognitive control. Older adults’ memory was more sensitive to socioemotional rewards, whereas younger adults’ memory was more sensitive to financial gains.

Discussion
Findings are discussed with reference to the dopamine hypothesis of cognitive aging and to life-span theories of motivational orientation. None of these theories is fully supported by the meta-analysis findings, highlighting the need for an integration of neurobiological, cognitive process, and life-span-motivational perspectives.
Adaptive coloured noise multirate Kalman filter and its application in coseismic deformations
Authors: Chen Changxin , Lin Xu , Li Wei , Cheng Lin , Wang Hongyue , Zhang Qingqing , Wang Zhen 
Published: March 2023

SUMMARYThe accuracy and sampling rate of a coseismic displacement and velocity waveform can be improved by fusing Global Navigation Satellite System (GNSS) and strong motion (SM) sensor data with a multirate Kalman filter. However, many studies have shown that the noise in GNSS coseismic waveforms includes coloured noise, and it is challenging to obtain proper GNSS and SM fusion results if the GNSS coloured noise is not accurately represented. In this paper, we propose a coloured noise multirate Kalman filter, which uses a stochastic model for modelling the GNSS coloured noise to achieve an accurate fusion of data from GNSS and SM for different sampling rates. In addition, we also propose an estimation method for the multirate Kalman filter stochastic model under coloured noise to achieve the optimal adaptive fusion of GNSS and SM data. After the reliability of the proposed method was confirmed using Monte Carlo simulations and earthquake engineering data tests, the proposed method was applied to data collected from the 2019 Mw 7.1 Ridgecrest earthquake and 2016 Mw 7.8 Kaikoura earthquake. The test results show that the proposed method can effectively fuse GNSS and SM data and accurately obtain broadband coseismic displacement and velocity waveforms.
The performance of differential point positioning using low-cost GNSS in comparison to DInSAR for monitoring coseismic displacement of the Provenzana–Pernicana fault system (Mt. Etna, 2018 December eruptive phase)
Authors: Wilkinson M W , Bonforte A , Jones R R , Wadsworth F B , Roberts G P , Guglielmino F 
Published: March 2023

SUMMARY
Mt. Etna is a perfect laboratory for testing new approaches and new technologies in a very active geodynamic environment. It offers, in fact, the opportunity for measuring active crustal deformation, related to volcanic activity as well as to seismic faulting on its flanks. In this work, a network of low-cost/low-power Global Navigation Satellite System stations has been installed and tested on Mt. Etna, across a very active fault, the Provenzana–Pernicana system, cutting its north-eastern flank. During the test period, a lateral eruption occurred (starting on 2018 December 24), with a forceful dyke intrusion that stressed all the flanks of the volcano, soliciting all the main faults dissecting the edifice. Also the Provenzana–Pernicana fault system, where this network was recording, was activated during the dyke intrusion, producing a significant seismic swarm. The low-cost/low-power network data analysis allowed the fault slip during the intrusion to be clearly traced in time and space at all the stations lying on the hangingwall mobile block of the fault. All the stations lying south of the fault trace showed an eastward displacement, in very good agreement with the usual kinematics of the fault and the temporal duration of the M 3.5 December 24 earthquake, related to the seaward dislocation of the eastern mobile flank of the volcano, promoted and accelerated by dyke emplacement on the upper part of the edifice.