bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Like a weight off my shoulders”: Participating in peer support from the perspectives of young people experiencing homelessness
Authors: Mollica Meredith , Littman Danielle M. , Lucas Thomas , Marvin Connor , Erangey James , Bender Kimberly , Milligan Tara 
Published: March 2023

AbstractThe aim of this study is to explore how young people experiencing homelessness or housing instability experience participating in peer support from paid peer support specialists with shared lived experiences. The present study used participatory qualitative methods, specifically a photovoice project with young people (N = 8) experiencing homelessness or housing instability, to understand their experiences of being in a relationship with a peer support specialist. This study found that young people experiencing homelessness or housing instability experienced peer relationships as uniquely caring and affirming. Young people described peers as “feeling like a friend” and repeatedly expressed that peer support is “deeper than therapy.” This sort of support stands in contrast to many conventional service approaches, which tend to be driven by organizational agendas and outcomes leading young people to disaffiliate from services. These findings may guide peer support specialists, service providers beginning peer programming, or those considering models for engaging young people experiencing homelessness.
Ni‐based metal organic frameworks: an efficient catalyst for the amidation reaction to obtain N‐(pyridin‐2‐yl)arylamides
Authors: Nguyen Oanh T. K. , Nguyen Vinh Huu , Nong Linh Xuan 
Published: March 2023

AbstractBackgroundAmides are the essential building blocks of natural products and bioactive molecules. One of the most common structures discovered in medicinal and bioactive compounds is amide derivatives. The synthesis of N‐(pyridin‐2‐yl)arylamide compounds has recently been assessed using various methods. In particular, there is growing interest in employing heterogeneous catalysts to catalyze organic synthesis reactions. Metal organic frameworks based on nickel centers were synthesized using the solvothermal method. The morphology, size, and catalytic activity of Ni‐based catalysts strongly depend on the substitute solvent composition in the reaction system. The structural features of the Ni‐based materials were verified using modern analytical techniques.ResultsNi‐based materials were used to catalyze the synthesis of physiologically important N‐(pyridin‐2‐yl)arylamides through an amidation reaction between 2‐aminopyridine and benzaldehyde. Temperature, reaction time, catalyst amount, reactant ratio, and solvent type were investigated as factors that influenced the catalytic activity. The optimal reaction conditions were 10 mol% Ni‐based catalysts, tetrahydrofuran as the reaction solvent, and a reaction temperature of 90 °C for 24 h. N‐(pyridin‐2‐yl)arylamide was obtained in approximately 85% yield. The catalyst could be recovered and reused without significant loss of catalytic activity (79%) after six runs.ConclusionThis study illustrated that the Ni‐based catalyst performed well in the reaction between 2‐aminopyridine and benzaldehyde formation N‐(pyridin‐2‐yl)arylamide compound with an 85% yield. The solid catalyst was recovered and reused up to six times without any significant change in catalytic activity. © 2023 Society of Chemical Industry (SCI).
Transcriptomics and metabolomics reveal the changes induced by arbuscular mycorrhizal fungi in Panax quinquefolius L.
Authors: Ran Zhifang , Chen Xiaoli , Li Rui , Duan Wanying , Zhang Yongqing , Fang Lei , Guo Lanping , Zhou Jie 
Published: March 2023

AbstractBackgroundPanax quinquefolius L. is one of the most important foods and herbs because of its high nutritional value and medicinal potential. In our previous study we found that the ginsenoside content in P. quinquefolius was improved by arbuscular mycorrhizal fungi (AMFs). However, little research has been conducted on the molecular mechanisms in P. quinquefolius roots induced by AMFs colonization. To identify the metabolomic and transcriptomic mechanisms of P. quinquefolius induced by AMFs, non‐mycorrhized (control) and mycorrhized (AMF) P. quinquefolius were used as experimental materials for comparative analysis of the transcriptome and metabolome.ResultsCompared with the control, 182 metabolites and 545 genes were significantly changed at the metabolic and transcriptional levels in AMFs treatment. The metabolic pattern of AMFs was changed, and the contents of ginsenosides (Rb1, Rg2), threonine, and glutaric acid were significantly increased. There were significant differences in the expression of genes involved in plant hormone signal transduction, glutathione metabolism, and the plant–pathogen interaction pathway. In addition, several transcription factors from the NAC, WRKY, and basic helix–loop–helix families were identified in AMFs versus the control. Furthermore, the combined analysis of ‘transcriptomics–metabolomics’ analysis showed that ‘Plant hormone signal transduction’, ‘Amino sugar and nucleotide sugar metabolism’ and ‘Glutathione metabolism’ pathways were the important enriched pathways in response to AMFs colonization.ConclusionOverall, these results provide new insights into P. quinquefolius response to AMFs, which improve our understanding of the molecular mechanisms of P. quinquefolius induced by AMFs. © 2023 Society of Chemical Industry.
Humic acid chelated selenium is suitable for wheat biofortification
Authors: Lei Hongliang , Zhou Miaoguo , Li Ban , Fu Yanan , Shi Zhaoyang , Ji Wanquan , Zhang Rui , Wang Zhonghua 
Published: March 2023

AbstractBACKGROUNDSelenium rich bread is a good carrier of selenium, but the inorganic selenium used in the actual production process is toxic. It is necessary to develop a new green bread production technology. The extraction and utilization of humic acid chelated selenium from selenium‐rich soil is beneficial for reducing resource waste and pollution without destroying the soil ecosystem in selenium‐deficient areas. Sodium selenite and nanoselenium were selected as controls because they are commonly used as selenium agronomic enhancers in production.RESULTSHumic acid chelated selenium can be absorbed and accumulated by wheat leaves, and humic acid chelated selenium had no significant effect on wheat yield, which was also shown in the treatments with nanoselenium and sodium selenite. Excessive accumulation of selenium in wheat grains can lead to a deterioration of processing quality. Among them, the use of excessive nanoselenium at the filling stage inhibited the accumulation of wheat grain protein, whereas humic acid chelated selenium is beneficial to grain protein accumulation and has the least negative effect on the processing quality. The accumulation of excessive selenium in wheat seeds had a negative effect on seed germination and growth; specifically, the seed vigor of wheat treated with humic acid chelated selenium was higher than that of untreated wheat.CONCLUSIONHumic acid chelated selenium is particularly suitable for the whole process of Se‐enriched bread wheat production. The seed vigour of wheat treated with humic acid chelated selenium, which supplied a moderate amount of selenium, was higher than that of untreated wheat. Conversely, the accumulation of excessive selenium in wheat seeds reduced germination and seedling growth. © 2023 Society of Chemical Industry.
Cosmetic Filler and PET Positivity: The Risk of a False Positive
Authors: Eitan Dana Naomi , Grunebaum Lisa Danielle , Howard Brittany Emma 
Published: March 2023

ObjectiveTo discuss a case of hyaluronic acid filler displaying as PET avid resulting in a false positive for local recurrence and review of the literature of how filler presents on PET.Study DesignCase report and literature review.MethodsRetrospective case review of a patient with angiosarcoma with PET‐MRI positivity after hyaluronic acid filler injection. Review of the literature was performed.ResultsA 49‐year‐old female with low grade angiosarcoma of the right cheek pT1N0M0 was treated with wide local excision and staged reconstruction with cervicofacial advancement flap with subsequent adjuvant radiation therapy. Surveillance PET/MRI scans were conducted every 3 months. After one year without recurrence, HA injectable filler was offered to correct resultant right facial soft tissue defect. The patient proceeded with HA filler and was counseled on the risk of local increased SUV on imaging. Her PET/MRI 3 months later revealed postsurgical changes in the right premaxillary soft tissues with associated low‐grade hypermetabolism with max SUV 1.8, which elevated from prior max SUV 0.9. Contralateral left maxillary soft tissues revealed max SUV 0.8. Biopsy was initially favored for concern of local recurrence until the potential for filler to be associated with elevated SUV was discussed. Further evaluation with MRI showed diffusely increased T2 signal with some trace enhancement in the region of PET activity, confirming that findings were consistent with HA filler augmentation per the neuroradiologist team.ConclusionsFillers, including hyaluronic acid, are associated with elevated SUV on PET‐CT. Otolaryngologists should be aware of these features to improve patient counseling, avoid unnecessary procedures, and reduce patient anxiety. Laryngoscope, 133:2951–2953, 2023
Surgiflo® hemostatic matrix versus NasoPore® nasal packing following postassium titanyl phosphate laser surgery for hereditary hemorrhagic telangiectasia: A randomized controlled trial
Authors: Pyne Justin M. , Murray Scott , Kelly Brendan C. , Song Jin Soo , Rosvall Brandon R. , Côté David W. J. 
Published: March 2023

AbstractBackgroundTo help ensure adequate hemostasis immediately following potassium titanyl phosphate (KTP) laser treatment, many centres treating hereditary hemorrhagic telangiectasia (HHT) routinely use nasal packing post‐operatively. The purpose of this study was to compare hemostatic thrombin matrix with standard packing for postoperative bleeding, patient pain, and comfort.MethodsA prospective, randomized, double‐blinded, non‐inferiority study was conducted with participants at an HHT centre of excellence (COE) and randomized to the treatment group with reconstituted thrombin gelatin matrix (Surgiflo®) or control group with a biodegradable synthetic polyurethane foam (NasoPore®). Adult subjects with confirmed HHT and moderate to severe epistaxis (a minimum calculated epistaxis severity score [ESS] of 4.0) warranting KTP laser treatment were recruited. Data was collected 2 weeks post operatively by a blinded reviewer completing a visual outcomes evaluation and each patient completing a subjective symptoms questionnaire. Non‐parametric statistical analysis was employed.ResultsTwenty‐eight adult patients were randomized to the treatment and control arms with comparable preoperative epistaxis severity scores. Postoperative nasal bleeding was equivalent. Significantly less pain was found in the treatment arm (p = .005). While there were trends towards less obstruction and increased satisfaction in the treatment group as well as less crusting in the control group, these findings were not statistically significant. Allocation to the treatment group was associated with an approximately $75 higher cost.ConclusionsWhen compared to NasoPore® for hemostasis, Surgiflo® hemostatic matrix performed equivalently while causing less discomfort in HHT patients following nasal KTP treatment.Level of evidence1b.
Anaerobic duration predicts biogeochemical consequences of oxygen depletion in lakes
Authors: LaBrie Richard , Hupfer Michael , Lau Maximilian P. 
Published: March 2023

AbstractLake deoxygenation is of growing concern because it threatens ecosystem services delivery. Complete deoxygenation, anoxia, is projected to prolong and expand in lakes, promoting the production or release of nutrients, greenhouse gases and metals from the water column and sediments. Accumulation of these compounds cannot be easily predicted thus hindering our capacity to forecast the ecological consequences of global changes on aquatic ecosystems. Here, we used monitoring data of four lakes to develop a novel tool, anaerobic duration, to study anaerobic processes in lake waters. Anaerobic duration explained, as a single predictor, 21–60% of the variation for ammonium, phosphorus and a dissolved organic matter fluorophore. Anaerobic duration could be modeled using only two oxygen profiles and lake bathymetry, making it an easily applicable tool to interpret and extrapolate biogeochemical data. This novel tool thus has the potential to transform widely available oxygen profiles into an ecologically meaningful variable.
Electro‐optic modulator based on vanadium dioxide epsilon‐near‐zero nanorods embedded in silicon slot waveguide
Authors: Tanyi Gregory , Lim Christina , Unnithan Ranjith R. 
Published: March 2023

AbstractWe present an electro‐optic modulator exploiting a metamaterial made of an array of vanadium dioxide nanorods operating in epsilon‐near‐zero regime as the active switching material in a silicon waveguide. The modulator takes advantage of the insulator‐to‐metal transition of vanadium dioxide along with near‐zero effective permittivity to achieve a modulation depth of 19.7 dB µm–1 in a footprint of 1.6 µm × 1 µm over a broad range of wavelengths. Using simulations, we demonstrate how the effective permittivity of the metamaterial can be tuned to a near‐zero value by varying the nanorod geometry to increase the modulation depth. The paper further investigates a novel hexagonal array design using the metamaterial nanorods to obtain a lower insertion loss and high modulation depth. The results provide insight into the design of ultra‐compact epsilon‐near‐zero modulators with high operation frequencies and low insertion losses.
Feasibility and validity of using healthcare databases to conduct cross‐national comparative studies of opioid use, its determinants and consequences
Authors: Chen Teng‐Chou , Wettermark Björn , Steinke Douglas , Caughey Gillian E. , Tadrous Mina , Wirtz Veronika J. , Chen Li‐Chia ,   the Global Opioid Utilization Research Collaborative Group
Published: March 2023

AbstractPurposeA cross‐national comparative (CNC) study about opioid utilization would allow the identification of strategies to improve pain management and mitigate risk. However, little is known about the accessibility and validity of information in healthcare databases internationally. This study aimed to identify the feasibility of using healthcare databases to conduct a CNC study of opioid utilization and its associated consequences.MethodsA cross‐sectional survey was launched in March 2018, including experts interested in CNC studies comparing opioid utilization by purposeful sampling. An electronic survey was used to collect database characteristics, medicine information, and linkage information of each aggregate‐level dataset (AD) and individual patient‐level dataset (IPD).ResultsOverall, participants from 21 geographical regions reported 18 ADs and 19 IPDs. Information on dispensed medications is available from 17 ADs and 17 IPDs. Of the 16 ADs that include primary care settings, only 9 ADs can obtain information from secondary care settings. Fourteen IPDs included patients' characteristics or could be retrieved from linkage databases. Although most ADs are publicly accessible (n = 13), only five IPDs can be accessed without extra cost.ConclusionMost ADs could be used to report opioid utilization in a primary care setting. IPDs with linkage databases should be applied to identify potential determinants, clinical outcomes, and policy impact. Data access restrictions and governance policies across jurisdictions can be challenging for timely analysis and require further collaboration.
Identifying a urinary peptidomics profile for hypertension in young adults: The African‐PREDICT study
Authors: De Beer Dalene , Mels Catharina M.C. , Schutte Aletta E. , Delles Christian , Mary Sheon , Mullen William , Latosinska Agnieszka , Mischak Harald , Kruger Ruan 
Published: March 2023

AbstractHypertension is one of the most important and complex risk factors for cardiovascular diseases (CVDs). By using urinary peptidomics analyses, we aimed to identify peptides associated with hypertension, building a framework for future research towards improved prediction and prevention of premature development of CVD. We included 78 hypertensive and 79 normotensive participants from the African‐PREDICT study (aged 20–30 years), matched for sex (51% male) and ethnicity (49% black and 51% white). Urinary peptidomics data were acquired using capillary‐electrophoresis‐time‐of‐flight‐mass‐spectrometry. Hypertension‐associated peptides were identified and combined into a support vector machine‐based multidimensional classifier. When comparing the peptide data between the normotensive and hypertensive groups, 129 peptides were nominally differentially abundant (Wilcoxon p < 0.05). Nonetheless, only three peptides, all derived from collagen alpha‐1(III), remained significantly different after rigorous adjustments for multiple comparisons. The 37 most significant peptides (all p ≤ 0.001) served as basis for the development of a classifier, with 20 peptides being combined into a unifying score, resulting in an AUC of 0.85 in the ROC analysis (p < 0.001), with 83% sensitivity at 80% specificity. Our study suggests potential value of urinary peptides in the classification of hypertension, which could enable earlier diagnosis and better understanding of the pathophysiology of hypertension and premature cardiovascular disease development.
The sustainable development goals: How does their implementation affect the financial sustainability of the largest Spanish municipalities
Authors: Benito Bernardino , Guillamón María‐Dolores , Ríos Ana‐María 
Published: March 2023

AbstractThe Sustainable Development Goals (SDGs) present a universal challenge to which all society must be committed. Local governments play a fundamental role as they are closest to citizens, with first‐hand knowledge of their needs and as providers of essential services. Municipal governments are involved in many aspects of SDG implementation. Thus, these governments should work towards their implementation, bearing in mind that involvement in these issues may affect municipal finances. This paper analyses the impact of SDG implementation by local governments on financial sustainability. Our results show that municipalities with better SDG compliance have shorter supplier payment periods and smaller surpluses (or higher deficits). However, better implementation does not affect gross savings or municipal debt per capita.
Enhanced Electrochemical Ethanol Sensitivity on Ni/NiO‐rGO Hybrids Nanostructures at Room Temperature
Authors: Mali Shivsharan M. , Narwade Shankar S. , Mulik Balaji B. , Digraskar Renuka V. , Harale Rajkumar R. , Sathe Bhaskar R. 
Published: March 2023

AbstractHerein, we depict that the consequential nickel/nickel oxide‐reduced graphene oxide (Ni/NiO‐rGO) hybrid materials synthesized by sol‐gel approach can give as competent electrocatalyst for oxidative determination of ethanol in alkaline condition. Ni/NiO‐rGO based electrochemical sensor shows rapid and highly sensitive linear sweep voltametric (LSV) response to ethanol at an ultra‐low oxidation potential of 0.33 V vs. SCE. Moreover, the electrochemical sensor demonstrates highly stable (current and potential) also with low charge transfer resistance confirmed from chronoamperometic (i‐t) and electrochemical impedance spectroscopic (EIS) data respectively towards ethanol oxidation at Ni/NiO‐rGO hybrid interface confirms its acitivity over individuals i. e. Ni/NiO nanoparticles and rGO. Moreover, linear increase in current density upto 100 μM concentration of ethanol and for the scan rates in the range of 10–100 mV/s with positive shift in potential confirms ethanol oxidation is diffusion controlled process. The selective analysis of electrochemical response for ethanol in benadryl sample with same oxidation potential of ethanol beverages with enhanced ethanol oxidation potential for determination of ethanol concentration into benadryl sample analysis.
Determination of Antioxidant Activities of Viscum album L.: First Report on Interaction of Phenolics with Survivin Protein using in silico Analysis
Authors: Korcan Safiye Elif , Çankaya Nevin , Azarkan Serap Yalcın , Bulduk İbrahim , Karaaslan Emre Can , Kargıoğlu Mustafa , Konuk Muhsin , Güvercin Gencer 
Published: March 2023

AbstractMistletoe, Viscum album L., (VA) known as “Ökse Otu” in Turkey, is a hemiparasitic shrub that grows especially on the trunks and crowns of broadleaf trees. This study is aimed to determination of the VA’s antioxidant compounds and evaluate their in vitro activities growing on twelve different host trees and determination of in silico approach of compounds against survivin protein. At the same time, the active ingredients determined in HPLC analysis, were performed with molecular docking and molecular dynamics analysis on survivin protein, an apoptosis inhibitor protein in cancer. Antioxidant activities of methanolic extracts of organs of VA were determined. Phytochemical properties of different organs of VA samples taken from different hosts varied as well. Total phenolic content was determined at the highest rate in fruits, followed by leaves and branches, respectively. Total flavonoid content was determined in the highest amounts in the leaves, followed by branches and fruits, respectively. Antioxidant activity values were evaluated with DPPH (using DPPH as a radical), ABTS (using ABTS as radical cation) and FRP tests. The antioxidant activity of the branches of the plant was determined at the highest rate, followed by leaves and fruits, respectively. During in silico analysis, Quercetin, Rosmarinic acid and Catechin were found to bind to survivin protein effectively. These substances can have the potential to become active pharmaceutical ingredients by working with different proteins in the future.
Ruthenium(III) Chloride as an Efficient Catalyst for the Selective Oxidation of Fatty Alcohols to Aldehydes
Authors: Nunheim Nelly F. , Kaiser Bianca , Thiel Werner R. 
Published: March 2023

AbstractThe oxidation of a series of fatty alcohols to yield the corresponding aldehydes is performed using RuCl3 ⋅ (H2O)x as a homogeneous catalyst and inexpensive trimethylamine N‐oxide (TMAO) as the oxygen source. The reaction conditions were optimized for both high conversion and high selectivity.
Synthesis, Characterization and Structural Studies of Novel Pyrazoline Derivatives as Potential Inhibitors of NAD+ Synthetase in Bacteria and Cytochrome P450 51 in Fungi
Authors: Praveen Kumar Cingatagere Hanumanthappa , Katagi Manjunatha S. , Samuel Johnson , Nandeshwarappa Belakatte P. 
Published: March 2023

AbstractIn the present study, a series of novel 1‐Methyl‐3‐(3‐oxo‐3‐phenylprop‐1‐enyl) quinoline‐2‐(1H)‐ones derivatives(3 a–3 i)were synthesized via condensation, followed by the ring closure to produce pyrazoline derivatives (4 a–4 i). All the newly synthesized pyrazolines derivatives were determined by spectroscopic techniques and were tested for antimicrobial activity by agar well diffusion assay and MIC, from which it was observed that the compounds4 gand4 ishowed substantial antimicrobial activity against bacterial strains. Whereas compound4 iexhibited remarkable antifungal activity. Post this, computational methodologies were employed for studying the pharmacokinetic profiles and assessing the drug likeness of the title compounds. They were subjected to molecular docking analysis and it was observed that the proposed antibacterial compounds4 gand4 ishowed significant binding to the active site of NAD+ synthetase enzyme of the bacteria and the proposed antifungal compound4 ishowed significant binding towards the active site of Cytochrome P450 51 in fungi.