bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in normalized mutual information in response to strength training: An ancillary analysis of a quasi‐randomized controlled trial
Authors: Kristiansen Mathias , Hansen Ernst Albin , Samani Afshin , Madeleine Pascal 
Published: August 2023

AbstractThe aim of the present investigation was twofold. (1) to assess test–retest reliability of normalized mutual information (NMI) values extracted from the surface electromyography (sEMG) signal of muscles pairs of the upper body during dynamic bench press at a high load, and (2) to assess changes in NMI values from before to after a five‐week quasi‐randomized controlled bench press training intervention. For test–retest reliability, 20 strength trained males (age 25 ± 2 years, height 1.81 ± 0.07 m) performed two three‐repetition maximum (3RM) tests in bench press, while sEMG was recorded from six upper body muscles. Tests were separated by 8.2 ± 2.9 days. For the training intervention, 17 male participants (age 26 ± 5 years, height 1.80 ± 0.07 m) trained bench press specific strength training for 5 weeks (TRA), while 13 male participants (age 23 ± 3 years, height 1.80 ± 0.08 m) constituted a control group (CON). 3RM bench press test and sEMG recordings were carried out before and after the intervention period. The NMI values ranged from poor to almost perfect reliability, with the majority displaying substantial reliability. TRA displayed a significant decrease in NMI values during the concentric phase for two agonist–agonist muscle pairs, while one agonist–agonist and two agonist–antagonist muscle pairs increased the NMI values during the eccentric phase. The observed changes did not exceed the minimal detectable threshold, and we therefore cannot surely ascertain that the changes observed in NMI values reflect genuine neural adaptations.
Lip color measurement: A new hyperspectral imaging device
Authors: Vergnaud Héloïse , Cherel Marie , Francois Ghislain , Charton Zoé , Loescher Eléonore , Caisey Laurence , Gazano Germaine 
Published: August 2023

AbstractIntroductionThe lips are of significant interest among the facial features for self‐perception and social interactions. Such perceptions could rely in part upon the contrast in color between the lips and the surrounding skin. In contrast to skin color, lip color ethnic diversity measurement provides a challenge and is less documented in the literature, most likely due primarily to challenges in measurement based upon the lip characteristics of size and contour. Accurate measurement and reproduction of lip color are essential to build strong cross‐sectional knowledge about lip color.ObjectiveThis preliminary experiment of a large‐scale project on lip and skin color was designed to assess accuracy in lip color measurement and recommend instruments and protocols for good measurement practice.MethodsThe study involved 19 healthy French Caucasian women. Their inferior and superior natural lip color was measured twice with three devices in order to extract the standard colorimetric parameters of lightness (L*), chroma (C*), and hue (h): the VISIA‐CR® (high‐resolution digital camera, Canfield Scientific Inc.); the spectrophotometer VS3200 (45°:0° spectrophotometer, MetaVue™ VS3200, X‐Rite Inc.); and the SpectraFace® (new hyperspectral imaging system, Newtone Technologies). The intercomparison and color distribution between the different instruments and the measurement repeatability of each one were assessed.ResultsOur results showed a reliable and equivalent repeatability for the three tested instruments. Moreover, the three tools led to the same conclusion regarding lip color heterogeneity (lighter, redder, less yellow and more saturated inferior lip versus superior lip). Agreement between the SpectraFace® and the spectrophotometer measurements was higher, and the SpectraFace® allowed to identify three separated lip color typologies.ConclusionIn conclusion, the combination of imaging technology and hyperspectral measurement makes the SpectraFace® a useful tool to investigate lip color characterization and establish a large‐scale cross‐sectional knowledge study about lip color.
From zero surgeries to candidates for exotic definite 4‐manifolds
Authors: Manolescu Ciprian , Piccirillo Lisa 
Published: August 2023

AbstractOne strategy for distinguishing smooth structures on closed 4‐manifolds is to produce a knot in that is slice in one smooth filling of but not slice in some homeomorphic smooth filling . In this paper, we explore how 0‐surgery homeomorphisms can be used to potentially construct exotic pairs of this form. To systematically generate a plethora of candidates for exotic pairs, we give a fully general construction of pairs of knots with the same zero surgeries. By computer experimentation, we find five topologically slice knots such that, if any of them were slice, we would obtain an exotic 4‐sphere. We also investigate the possibility of constructing exotic smooth structures on in a similar fashion.
Sport Specialization’s Impact on Female Adolescent Athletes’ Lower-Extremity Neuromuscular Control: A Critically Appraised Topic
Authors: Reich Sierra , Hawkins Jeremy , Powell Alli , Reeder Michael 
Published: August 2023

Clinical Scenario: Nearly 60 million youth ages 6–18 participate in athletics within the United States. Over the last 30 years, the outlook on youth sport participation has drastically changed, resulting in an increased emphasis on performance and college sport participation. These evolving expectations have created a sense of perfectionism, demanding more time and energy to be placed into a single sport, resulting in an increased prevalence of sport specialization, and consequently, an increased rate of injury. Clinical Question: What is the impact of sport specialization on lower-extremity neuromuscular control in female adolescent athletes? Summary of Key Findings: Four studies were included, all comparing movement efficiency and movement patterns among multisport and sport-specialized female adolescent athletes. Three studies showed that sport specialization is associated with lower-extremity biomechanical alterations that are indicative of altered levels of neuromuscular control, which can predispose an individual to an increased risk of injury. One study concluded that no differences in neuromuscular control exist when comparing sport-specialized to multisport adolescent female athletes. Clinical Bottom Line: Sport specialization has the potential to create negative alterations in a female adolescent athletes’ lower-extremity biomechanics, leading to the creation of altered levels of neuromuscular control and a possible increased risk for injury. Strength of Recommendation: Level B evidence exists to support the conclusion that sport specialization negatively affects a female adolescent athlete’s lower-extremity neuromuscular control.
Effect of Low-Load Blood Flow Restriction Training on Patients With Functional Ankle Instability: A Randomized Controlled Trial
Authors: Wen Ziliang , Zhu Jiang , Wu Xuelian , Zheng Bing , Zhao Li , Luo Xin , Wu Zonghui 
Published: August 2023

Context: Decreased muscle strength and balance in patients with functional ankle instability (FAI) can be effectively improved by ankle strength training. Low-load blood flow restriction (LL-BFR) training increases muscle size and strength, but there is limited evidence from studies on muscle strength and balance in FAI patients. Objective: To study the effects of LL-BFR training versus high-load training (HLT) on muscle strength and balance in FAI patients. Design: Randomized controlled trial. Participants: Forty-six young adults with a history of FAI. Interventions: Participants in the LL-BFR and HLT groups performed 4 sets (30 × 15 × 15 × 15) of ankle training at 20% to 40% of the one-repetition maximum and 70% to 85% one-repetition maximum, respectively, twice a week for 6 weeks. Main Outcome Measure(s): Plantar flexion, dorsiflexion, inversion, and eversion muscle strength, and the Y-balance test scores were assessed at baseline and after 3 and 6 weeks; the thickness of the tibialis anterior, triceps surae, and peroneus longus muscles were assessed at baseline and after 6 weeks. Results: Inversion, eversion, dorsiflexion, and plantar flexion muscle strength; tibialis anterior, triceps surae, and peroneus longus thickness; and Y-balance test scores were significantly increased in the LL-BFR group after 3 and 6 weeks compared with baseline (P < .05), with no significant difference between the LL-BFR and HLT groups after 6 weeks (P > .05). However, at the end of 3 weeks, eversion muscle strength and Y-balance test scores were significantly higher in the LL-BFR group than in the HLT group (P < .05). Conclusions: Over 6 weeks, LL-BFR training was as effective as HLT in improving ankle muscle strength, muscle thickness, and balance in FAI patients, but LL-BFR training improved the ankle eversion muscle strength and dynamic balance more than HLT did in the early stages of the intervention. This finding will provide a new intervention strategy for the clinical rehabilitation of FAI patients.
Supplemental Material: Construction and Modification of Debris-Flow Alluvial Fans as Captured in the Geomorphic and Sedimentary Record: Examples from the Western Sangre de Cristo Mountains, South-Central Colorado
Authors: Nicovich Sylvia 
Published: August 2023

<p>Plate 1: Surficial Geologic Map of Alluvial Fans and Related Deposits along the Northern Sangre de Cristo Range Front, South-Central Colorado, USA </p>
Experience of reassessingFBN1variants of uncertain significance by gene-specific guidelines
Authors: Yoon Eungjun , Lee Jong Kwon , Park Taek Kyu , Chang Sung-A , Huh June , Kim Jong-Won , Kim Duk-Kyung , Jang Ja-Hyun 
Published: August 2023

AbstractBackgroundDespite the 2015 American College of Medical Genetics and Genomics (ACMG) and Association of Molecular Pathology (AMP) guideline, many variants ofFBN1gene remain inconclusive. In line with publication of theFBN1-specific variant interpretation guideline by ClinGen in 2022, we reassessed variants of uncertain significance (VUS) inFBN1gene found in our institution.MethodsVUS found in the course ofFBN1sequencing between December 2015 and April 2022 were reassessed based onFBN1-specific variant interpretation guideline, review of updated literatures and additional genetic tests including family study and/or RNA study if available.ResultsOut of 695 patients who underwentFBN1sequencing, 61 VUS were found in 69 patients. Among them, 38 VUS in 43 patients (62.3%) were reclassified as pathogenic and likely pathogenic variant ((L)PV), including 20 novel (L)PV. Major causes of reclassification were: (1) gene-specific modification of ACMG/AMP criteria, (2) updated literatures and (3) additional genetic tests. The most important evidence for reclassification was clarification of critical amino acid residues.ConclusionsAfter reassessingFBN1variants according toFBN1-specific guideline and up-to-date database, a significant number of VUS was reclassified. Clinical laboratories are encouraged to perform variant reassessment at regular intervals or when there is a major change in the principle of variant interpretation.
A preliminary study on the effect of loaded and unloaded exercise on N-propeptide of type II collagen and serum cartilage oligomeric matrix protein activity of articular cartilage in healthy young adults
Authors: de Vasconcelos Bruna Mavignier , Peeler Jason D. , Scribbans Trisha , Cornish Stephen M. 
Published: August 2023

The serum concentration of cartilage oligomeric matrix protein (sCOMP) is considered a mechanosensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP), a proposed biomarker of type II collagen synthesis. Few studies have investigated the anabolic and turnover response of articular cartilage in response to acute changes in body mass during exercise. Using a repeated measure cross-over design, 15 healthy adults (age 18–30 years) performed three 30 min bouts of treadmill walking exercise under three loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 min after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP). A main time effect ( p ≤ 0.05) revealed that sCOMP levels were significantly greater post-exercise (for all three body loading conditions) as compared to before exercise, 15 and 30 min post-exercise. There was a significant condition × time interaction ( p ≤ 0.05) for PIIANP, indicating that in the loaded condition, PIIANP concentrations at 15 min post-exercise were 13.8% greater than immediately following exercise, and 12.9% greater than before exercise. In summary, sCOMP concentration was acutely increased with all three loading conditions. However, PIIANP increased only after exercise in the loaded condition, suggesting an acute anabolic effect on articular cartilage. NCT05925244.
Precision CMB constraints on eV-scale bosons coupled to neutrinos
Authors: Sandner Stefan , Escudero Miguel , Witte Samuel J. 
Published: August 2023

AbstractThe cosmic microwave background (CMB) has proven to be an invaluable tool for studying the properties and interactions of neutrinos, providing insight not only into the sum of neutrino masses but also the free streaming nature of neutrinos prior to recombination. The CMB is a particularly powerful probe of new eV-scale bosons interacting with neutrinos, as these particles can thermalize with neutrinos via the inverse decay process, $$\nu \bar{\nu } \rightarrow X$$

ν

ν

¯

→
X

, and suppress neutrino free streaming near recombination – even for couplings as small as $$\lambda _{\nu } \sim {\mathcal {O}}(10^{-13})$$

λ
ν

∼
O

(

10

-
13

)

. Here, we revisit CMB constraints on such bosons, improving upon a number of approximations previously adopted in the literature and generalizing the constraints to a broader class of models. This includes scenarios in which the boson is either spin-0 or spin-1, the number of interacting neutrinos is either $$N_{\textrm{int}} = 1,2 $$

N
int

=
1
,
2

or 3, and the case in which a primordial abundance of the species is present. We apply these bounds to well-motivated models, such as the singlet majoron model or a light $$U(1)_{L_{\mu }-L_{\tau }}$$

U

(
1
)

L
μ

-

L
τ

gauge boson, and find that they represent the leading constraints for masses $$m_X\sim 1\, {\textrm{eV}}$$

m
X

∼
1

eV

. Finally, we revisit the extent to which neutrino-philic bosons can ameliorate the Hubble tension, and find that recent improvements in the understanding of how such bosons damp neutrino free streaming reduces the previously found success of this proposal.
Germline Genetic Variants Associated with Somatic TMPRSS2:ERG Fusion Status in Prostate Cancer: A Genome-Wide Association Study
Authors: Ma Chaoran , Wang Xiaoyu , Dai James Y. , Turman Constance , Kraft Peter , Stopsack Konrad H. , Loda Massimo , Pettersson Andreas , Mucci Lorelei A. , Stanford Janet L. , Penney Kathryn L. 
Published: August 2023

Abstract

Background:
The prostate cancer subtype defined by the presence of TMPRSS2:ERG has been shown to be molecularly and epidemiologically distinct. However, few studies have investigated germline genetic variants associating with TMPRSS2:ERG fusion status.

Methods:
We performed a genome-wide association study with 396 TMPRSS2:ERG(+) cases, 390 TMPRSS2:ERG(−) cases, and 2,386 cancer-free controls from the Physicians’ Health Study (PHS), the Health Professionals Follow-up Study (HPFS), and a Seattle-based Fred Hutchinson (FH) Cancer Center Prostate Cancer Study. We applied logistic regression models to test the associations between ∼5 million SNPs with TMPRSS2:ERG fusion status accounting for population stratification.

Results:
We did not identify genome-wide significant variants comparing the TMPRSS2:ERG(+) to the TMPRSS2:ERG(−) prostate cancer cases in the meta-analysis. When comparing TMPRSS2:ERG(+) prostate cancer cases with controls without prostate cancer, 10 genome-wide significant SNPs on chromosome 17q24.3 were observed in the meta-analysis. When comparing TMPRSS2:ERG(−) prostate cancer cases with controls without prostate cancer, two SNPs on chromosome 8q24.21 in the meta-analysis reached genome-wide significance.

Conclusions:
We observed SNPs at several known prostate cancer risk loci (17q24.3, 1q32.1, and 8q24.21) that were differentially and exclusively associated with the risk of developing prostate tumors either with or without the gene fusion.

Impact:
Our findings suggest that tumors with the TMPRSS2:ERG fusion exhibit a different germline genetic etiology compared with fusion negative cases.
Sex-Specific Associations between Adiponectin and Leptin Signaling and Pancreatic Cancer Survival
Authors: Babic Ana , Wang Qiao-Li , Lee Alice A. , Yuan Chen , Rifai Nader , Luo Juhua , Tabung Fred K. , Shadyab Aladdin H. , Wactawski-Wende Jean , Saquib Nazmus , Kim Jihye , Kraft Peter , Sesso Howard D. , Buring Julie E. , Giovannucci Edward L. , Manson JoAnn E. , Stampfer Meir J. , Ng Kimmie , Fuchs Charles S. , Wolpin Brian M. 
Published: August 2023

AbstractBackground:Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated.Methods:Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific differences in adipokine levels, associations were evaluated separately for men and women. In a subset of 415 patients, we genotyped 23 SNPs in adiponectin receptor genes (ADIPOR1 and ADIPOR2) and 30 SNPs in the leptin receptor gene (LEPR).Results:Adiponectin levels were inversely associated with survival in women [HR, 1.71; 95% confidence interval (CI), 1.15–2.54]; comparing top with bottom quartile but not in men (HR, 0.89; 95% CI, 0.46–1.70). The SNPs rs10753929 and rs1418445 in ADIPOR1 were associated with survival in the combined population (per minor allele HR, 0.66; 95% CI, 0.51–0.84, and HR, 1.33; 95% CI, 1.12–1.58, respectively). Among SNPs in LEPR, rs12025906, rs3790431, and rs17127601 were associated with survival in the combined population [HRs, 1.54 (95% CI, 1.25–1.90), 0.72 (95% CI, 0.59–0.88), and 0.70 (95% CI, 0.56–0.89), respectively], whereas rs11585329 was associated with survival in men only (HR, 0.39; 95% CI, 0.23–0.66; Pinteraction = 0.0002).Conclusions:High levels of adiponectin in the prediagnostic period were associated with shorter survival among women, but not among men with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR are associated with patient survival.Impact:Our findings reveal the association between adipokine signaling and pancreatic cancer survival and demonstrate the importance of examining obesity-associated pathways in relation to pancreatic cancer in a sex-specific manner.
Efficacy and Safety of Stereotactic Body Radiotherapy Combined with Camrelizumab and Apatinib in Patients with Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
Authors: Hu Yue , Zhou Min , Tang Jing , Li Shuang , Liu Hongli , Hu Jianli , Ma Hong , Liu Junli , Qin Tingting , Yu Xiongjie , Chen Yongshun , Peng Jin , Zou Yanmei , Zhang Tao , Xue Jun 
Published: August 2023

Abstract

Purpose:
This study aimed to evaluate the efficacy and safety of camrelizumab plus apatinib with or without stereotactic body radiotherapy (SBRT) as first-line therapy for patients with hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).

Patients and Methods:
This is a multicenter, open-label, noncomparative, randomized trial that recruited patients with HCC with type II/III/IV PVTT, who had not previously received systemic therapy. Patients were randomly assigned (2:1) to receive camrelizumab (200 mg, every 3 weeks) and apatinib (250 mg, every day) with or without SBRT [95% planning target volume (PTV), 36–40 Gy/6–8 Gy]. The primary endpoint was overall survival (OS), and the secondary endpoints were progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), duration of response, time to progression, and safety.

Results:
Sixty patients were enrolled and randomly assigned to two prospective cohorts. Median OS were 12.7 months [95% confidence interval (CI), 10.2–not available (NA)] and 8.6 months (95% CI, 5.6–NA), and median PFS were 4.6 months (95% CI, 3.3–7.0) and 2.5 months (95% CI, 2.0–7.6) for the SBRT and non-SBRT cohorts, respectively. The ORR and DCR were 47.5% and 72.5% in the SBRT cohort, and 20.0% and 40.0% in the non-SBRT cohort. The most common treatment-related adverse events of any grade were hypertension (55.0%), hand-foot syndrome (51.7%), and leukopenia (50.0%). Grade ≥ 3 was reported in 13 (21.7%) patients.

Conclusions:
First-line treatment with camrelizumab–apatinib combined with or without SBRT showed clinical benefits in patients with HCC with PVTT, with an acceptable safety profile. Thus, these combination regimens may be potential options for such patients.
Клінічний випадок синдрому Вебера – Крісчена
Authors: Вайда А. Р. , Якимчук О. А. 
Published: August 2023

Синдром Вебера – Крісчена – системне захворювання, яке характеризується лобулярним панікулітом жирової клітковини з можливим ураженням внутрішніх органів. Синдром Вебера – Крісчена належить до рідкісної патології, що викликає труднощі діагностики та лікування даного захворювання. У статті описано випадок синдрому Вебера – Крісчена у 42-річної пацієнтки, яка страждала від даного захворювання впродовж 2 років, лікуючись від рецидивуючого тромбофлебіту.
Критерії ефективної ендоваскулярної ангіопластики багаторівневого атеросклеротичного стегно-оклюзивного ураження стегно-дистального артеріального русла
Authors: Венгер І. К. , Орлов М. П. , Костів С. Я. , Сельський Б. П. 
Published: August 2023

Мета роботи: спрямувати дослідження на вдосконалення ендоваскулярної ангіопластики магістрального артеріального русла нижньої кінцівки та встановити критерії її ефективності.
Матеріали і методи. Обстежено та виконано операційне лікування 73 пацієнтів: 69 (94,52 %) – чоловіки і 4 (5,48 %) – жінки, середній вік (62,91± 6,43) року. З метою визначення критеріїв ефективної ендоваскулярної ангіопластики у пацієнтів застосовували сучасні методики ультразвукової сонографії, комп’ютерної томографії та ангіографії, а також методів транскутанної оксиметрії.
Результати досліджень та їх обговорення. При аналізі отриманих результатів у пацієнтів, яким при дворівневій ендоваскурній реваскуляризації стегно-дистального артеріального русла здійснено ендоваскулярну ангіопластику двох гомілкових артерій, виявлено зростання як швидкості внутрішньошкірного кровотоку (ШВШК), так і підвищення рівня транскутанної напруги кисню (ТКНК). Встановлено, що показник ШВШК залежить від рівня клінічної стадії ХАН. Не виявлено помітної різниці від комбінації реваскуляризованих артерій гомілки. Встановлено, що показник ШВШК після реваскуляризації, не залежно від рівня клінічної стадії ХАН, зростав більш інтенсивніше порівняно із показниками ШВШК у доопераційного періоду і, що особливо слід підкреслити, це помітно при визначенні ШВШК у IV міжпальцевому проміжку.
Підвищення показника ШВШК та рівня ТКНК у I та IV міжпальцевому проміжках шкіри стопи вказує на досягнення позитивного результату ендоваскулярної реваскуляризації багаторівневого стенотично-оклюзивного ураження стегно-дистально артеріального русла як при ендоваскулярній ангіопластиці однієї, так і двох артерій гомілкового сегмента.
Ендоваскулярна ангіопластика стенотично-оклюзивного процесу двох артерій гомілкового сегмента, не залежно від рівня клінічної стадії ХАН, сприяє суттєво вищому і рівномірному підвищенню показника ШВШК та рівня ТКНК на тилі стопи порівняно із ендоваскулярною ангіопластикою стенотично-оклюзивного процесу однієї із гомілкових артерій.