bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric
Authors: Konisky Hailey , Bowe Whitney P. , Yang Pada , Kobets Kseniya 
Published: August 2023

AbstractBackgroundUltraviolet light, visible light, infrared light, and pollution are a few examples of environmental factors that exacerbate the formation of reactive oxygen species (ROS) that cause damage to skin cells' DNA, proteins, and lipids. By supplementing the skin with antioxidants, we can help neutralize ROS formed by these extrinsic factors before they can damage the skin.AimsThis prospective open‐label study explores the safety and efficacy of this novel topical formulation of antioxidants (vitamin C, astaxanthin, fermented turmeric, and vitamin E) designed to fight free radical damage and improve overall skin quality, as well as the appearance of fine lines, wrinkles, radiance, and hyperpigmentation of the skin.Patients/MethodsThis single‐center clinical study evaluated the efficacy of twice‐daily application of the test article (Asta C™ Vitamin C Age Defense Serum, Dr. Whitney Bowe Beauty) in 32 subjects for 12 weeks. Healthy female subjects aged 35–60 with mild to moderate fine lines, wrinkles, and hyperpigmentation/uneven skin tone were enrolled in this study. Fitzpatrick skin types I–VI, all skin types (dry, normal, combination, oily), and subjects with sensitive skin were included.ResultsAll subjects demonstrated improvement in overall skin quality (face, neck, and chest) by the end of the 12‐week study period. One hundred percent of subjects demonstrated improvement in the appearance of fine lines at Week 12.ConclusionsOverall, the current clinical study demonstrates that Asta C™ is safe, well‐tolerated, and effective in improving overall skin quality, as well as the appearance of fine lines, wrinkles, radiance, and hyperpigmentation of the skin.
Whose English gets paid off?—Neoliberal discourses of English and ethnic minority students’ subjectivities in China
Authors: Guo Xiaoyan (Grace) , Gu Michelle Mingyue 
Published: August 2023

AbstractThe study traces the trajectories of Uyghur college students’ subjectivity construction and transformation from Foucault's governmentality perspective. Drawing on ethnographic data of two telling cases, it explores how minoritized students’ subjectivities were linked to neoliberal discourses of English and constituted by power techniques, self‐technologies, and affective dispositions embedded in wider institutional transformations. Participants were found experiencing a shift to the individualistic subjectivity associated with academic achievement and performance in English away from the collective identity of “authentic Uyghur” symbolized by the Uyghur language. Two salient discourses of English, i.e., English as constraints, and English as academic excellence, emerging from the neoliberal‐oriented institutional English language education policies and practices, shaped the participants either as incompetent English learners or elite subjects. Participants learned to responsibilitize themselves through such self‐technologies as confession and preaching, and affective practices. Yet, technologies of hope and optimism became for a few the enjoyment of experiences and performance of elitism while projecting a majority disadvantaged as affectively problematic others. The self‐technologies and affective responses without recognition of larger structures of inequality could further reinforce the neoliberal logic. The affective labor of sense of solidarity, commitment to community, empathy for the deprived ones with critical reflection and collective action, nevertheless, may counter neoliberal logic and point to an alternative path to meaning‐making and social relations.
Spinal segmental myoclonus associated with CASPR2 antibody confounded by tethered cord
Authors: Sharma Bhawna , Gupta Ashish , Harish Hovale Bheemrao 
Published: August 2023

AbstractSpinal segmental myoclonus is rhythmic or semirhythmic involuntary contractions of muscle groups supplied by one or several contiguous segments of the brainstem and/or spinal cord evident with surface electromyographic (EMG) discharges. The clinical spectrum of contactin‐associated protein‐2 (CASPR2) autoantibody‐associated disorders is more diverse and reports on unusual, sometimes isolated, and immunotherapy‐responsive movement disorders in CASPR2 autoantibody‐associated syndromes have been described. We describe a rare case of spinal segmental myoclonus associated with CASPR2 antibody.
Nurse‐led intervention for the management of bariatric surgery patients: A systematic review
Authors: Mendes Cláudia , Carvalho Manuel , Oliveira Leandro , Rodrigues Luís Monteiro , Gregório João 
Published: August 2023

SummaryThe prevalence of obesity has become a global health concern, and severe obesity is associated with various chronic diseases and decreased quality of life. Bariatric surgery has shown success in treating obesity. Nevertheless, some patients experience weight regain and unsatisfactory outcomes. Multidisciplinary interventions have been shown to improve postoperative outcomes. Case managers, often specialized nurses, play a crucial role in patient support and coordination of care. However, the diverse design of case‐managing interventions hinders the assessment of their success. Thus, the aim of this review is to identify the most successful structural characteristics of case‐managing interventions, with or without the support of e‐Health, in the process of perioperative management of bariatric surgery patients. A systematic literature review was conducted following the PRISMA guidelines. PubMed, MEDLINE, EBSCOhost, and CINAHL databases were searched for relevant studies published in the last 10 years. Eligible studies included randomized controlled trials, controlled clinical studies, case studies, or observational studies that evaluated perioperative care in bariatric surgery. The PICO framework was used to frame the search strategy. The initial search yielded 225 articles, of which 10 studies met the inclusion criteria. Nurse‐led case‐managing interventions with a multidisciplinary approach showed positive results in weight loss, physical activity, and quality of life. Patient‐centered care models were found to promote adherence to treatment and patient satisfaction. E‐Health technologies improved quality of life but not weight loss. The duration of behavioral interventions and the long‐term outcomes after surgery remained unclear. Nurse‐led case‐management interventions, with a focus on behavioral change and multidisciplinary approaches, show promise in improving outcomes in bariatric surgery patients. Patient‐centered care models and longer term interventions may contribute to sustained weight loss and better postoperative outcomes. Further research is needed to determine the optimal duration of interventions and the long‐term effects on weight maintenance.
Quality of life after wearing multifocal contact lenses for myopia control for 2 weeks in the BLINK Study
Authors: Ticak Anita , Walline Jeffrey J. , Berntsen David A. , Mutti Donald O. , Jones‐Jordan Lisa A. , Cardenas Laura , Day Elizabeth , Dougherty Bradley E. ,   The BLINK Study Group
Published: August 2023

AbstractPurposeTo validate Pediatric Refractive Error Profile 2 (PREP2) subscales that can be used to evaluate contact lens wearers and compare vision‐specific quality of life measurements between children wearing multifocal and single vision contact lenses for 2 weeks.MethodsTwo hundred and ninety‐four myopic children aged 7–11 years (inclusive) were enrolled in the 3‐year, double‐masked Bifocal Lenses In Nearsighted Kids (BLINK) Study. Participants completed the PREP2 survey after having worn contact lenses for 2 weeks. The Vision, Symptoms, Activities and Overall PREP2 subscales were used to compare participants' subjective assessment while wearing +1.50 or +2.50 D add multifocal or single vision contact lenses. Rasch analysis was used to validate each subscale and to compare participants' subjective assessment of contact lens wear.ResultsItem fit to the Rasch model was good for all scales, with no individual items having infit mean square statistics outside the recommended range (0.7–1.3). Response category function was acceptable for all subscales, with ordered category thresholds. Measurement precision, assessed by the Rasch person reliability statistic, was less than ideal (≥0.8) for three of the subscales, but met the minimum acceptable standard of 0.5. Scores for the Vision subscale differed by treatment assignment (p = 0.03), indicating that participants with the highest add power reported statistically worse quality of vision, although the difference was only 3.9 units on a scale of 1–100. Girls reported fewer symptoms than boys (p = 0.006), but there were no other differences between boys and girls.ConclusionsRasch analysis demonstrates that the PREP2 survey is a valid instrument for assessing refractive error‐specific quality of life. These results suggest that vision‐related quality of life is not meaningfully affected by 2 weeks of soft multifocal contact lens wear for myopia control.
Reasons‐responsiveness, control and the negligence puzzle
Authors: Loewenstein Yael 
Published: August 2023

AbstractA longstanding puzzle about moral responsibility for negligence arises from three plausible yet jointly inconsistent theses: (i) an agent can, in certain circumstances, be morally responsible for some outcome O, even if her behavior with respect to O is negligent (i.e., even if she never adverted to the possibility that the behavior might result in O), (ii) an agent can be morally responsible for O only if she has some control over O, (iii) if an agent acts negligently with respect to O, then she has no control over O. This paper is in two parts. First, I argue that reasons‐responsiveness models of moral responsibility can be applied naturally to negligence scenarios; indeed, agents are intuitively responsible for the outcomes of their negligent behavior just when they meet the conditions for responsibility given by the best reason‐responsiveness theories. Second, if the reasons‐responsiveness conditions are applicable to negligence scenarios then one of two things follows: either agents can have direct control over outcomes they never adverted to, or reasons‐responsiveness is not a condition ofcontrolbut of something else connected to moral responsibility. Each possibility would be important in its own right—and each can solve the negligence puzzle.
Transcriptomic and physiological shade avoidance responses in potato (Solanum tuberosum) plants
Authors: Gómez‐Ocampo Gabriel , Cascales Jimena , Medina‐Fraga Ana L. , Ploschuk Edmundo L. , Mantese Anita I. , Crocco Carlos D. , Matsusaka Daniel , Sánchez Diego H. , Botto Javier F. 
Published: August 2023

AbstractPlants detect competitors in shaded environments by perceiving a reduction in photosynthetically active radiation (PAR) and the reduction between the red and far‐red light (R:FR) ratio and blue photons. These light signals are detected by phytochromes and cryptochromes, which trigger shade avoidance responses such as shoot and petiole elongation and lead to increased susceptibility to pathogen attack. We studied morphological, anatomical, and photosynthesis differences in potato plants (Solanum tuberosum var. Spunta) exposed to sunlight or simulated shade in a greenhouse. We found that simulated shade strongly induced stem and internode elongation with a higher production of free auxin in stems and a lower production of tubers. The mesophyll thickness of the upper leaves of plants grown in simulated shade was lower, but the epidermis was wider compared with the leaves of plants cultivated in sunlight. In addition, the photosynthesis rate was lower in the upper leaves exposed to nonsaturated irradiances and higher in the basal leaves at saturated irradiances compared with control plants. RNA‐seq analysis showed that 146 and 155 genes were up‐ and downregulated by shade, respectively. By quantitative reverse transcription polymerase chain reaction, we confirmed that FLOWERING LOCUS T (FT), WRKY‐like, and PAR1b were induced, while FLAVONOL 4‐SULFOTRANSFERASE was repressed under shade. In shaded plants, leaves and tubers were more susceptible to the necrotrophic fungus Botrytis cinerea attack. Overall, our work demonstrates configurational changes between growth and defense decisions in potato plants cultivated in simulated shade.
The role of fluvial and tidal currents on coal accumulation in a mixed‐energy deltaic setting: Pinghu Formation, Xihu Depression, East China Sea Shelf Basin
Authors: Shen Wenchao , Shao Longyi , Zhou Qianyu , Liu Jinshui , Eriksson Kenneth A. , Kang Shilong , Steel Ronald J. 
Published: August 2023

ABSTRACTThe Eocene Pinghu Formation in the Xihu Depression of the East China Sea Shelf preserves mixed‐process deltaic deposits and contains a large number of thin coal seams. This study improves the prediction of coal seam occurrences based on facies distribution and stratigraphic architecture models of deltaic deposits, using core and wireline log datasets. Sedimentological analysis reveals four facies associations, which represent delta plain (including distributary channels and interdistributary bays), delta front, prodelta and tidal flat. These facies associations reflect and preserve the interaction of fluvial and marine processes. Delta‐plain and delta‐front deposits record progressively greater tidal influences when traced southward. Well‐log correlations show that coal‐forming mires on the tide‐influenced lower delta plain were relatively favourable for peat accumulation because the stability of the tidal channels led to a stable platform for peat accumulation on the lower delta plain. The temporal and spatial distribution of coal seams is a function of both autogenic and allogenic responses to forcing. Increased probability of frequent changes in subsidence rates and sea‐level in an active tectonic setting and erosion by channels resulted in thin single‐layer coal seams (mostly 0.5 to 1.0 m). Autogenic processes (for example, delta growth and delta lobe switching) played a significant role in the areal distribution, lateral variation in thickness (ranging from 3 to 71 m) and large cumulative thicknesses (up to 71 m) of coal seams. A general vertical decrease in coal seam thickness likely records a cooling palaeoclimate during deposition of the Pinghu Formation. By comparing delta plain processes to favourable environments of peat accumulation in modern systems with favourable mineralogical, chemical and physical conditions, it can be concluded that: (i) relatively few and discontinuous coal seams developed on the tide‐dominated delta plain generated; (ii) laterally discontinuous and ribbon‐shaped coal seams developed in tide‐influenced deltas; whereas (iii) coal seams formed in river‐dominated deltaic environments have better lateral continuity.
World human neutrophil antigens investigation survey
Authors: Bayat Behnaz , Lowack Jonas , Audrain Marie , Croisille Laure , Curtis Brian , Dangerfield Rebecca , Esmaeili Behnaz , Grabowski Claudia , Keller Margaret , Kim Hyungsuk , Kroll Hartmut , Kvanka Marjeta Macek , Kwok Janette , Moritz Elyse , Nathalang Oytip , Nelson Derrick , Nielsen Kaspar René , Pahn Gail , Poles Anthony , Porcelijn Leendert , Sachs Ulrich J. , Schönbacher Marlies , Körmöczi Günther F. , Kupatawintu Pawinee , Takahashi Daisuke , Uhrynowska Malgorzata , Flesch Brigitte , Fung Yoke‐Lin 
Published: August 2023

AbstractBackground and ObjectivesHuman neutrophil antigens (HNAs) are categorized into five systems: HNA‐1 to HNA‐5. Given the importance of neutrophils in immunity, we sought to create awareness of the role of HNA diagnostic services in managing immune neutropenia and transfusion‐related acute lung injury. To provide health communities all around the world with access to these services, we conducted a survey to create a directory of these HNA diagnostic services.Materials and MethodsAn Excel table‐based survey was created to capture information on the laboratory's location and was emailed to 55 individuals with known or possible HNA investigation activity. The collected data were then summarized and analysed.ResultsOf contacted laboratories, the surveys were returned from 23 (38.2%) laboratories; 17 have already established HNA diagnostic (of them 12 were regular participants of the International Granulocyte Immunobiology Workshop [ISBT‐IGIW]), 4 laboratories were in the process of establishing their HNA investigation and the remaining 2 responder laboratories, did not conduct HNA investigations. In established laboratories, investigation for autoimmune neutropenia (infancies and adults) was the most frequently requested, and antibodies against HNA‐1a and HNA‐1b were the most commonly detected.ConclusionThe directory of survey respondents provides a resource for health professionals wanting to access HNA diagnostic services. The present study offers a comprehensive picture of HNA diagnostics (typing and serology), identifying weak points and areas for improvement for the first time. Identifying more laboratories involved in HNA diagnostics with limited access to international societies in the field will globally improve HNA diagnostics.
Recurrence Network-Based 3D Geometry Representation Learning for Quality Control in Additive Manufacturing of Metamaterials
Authors: Yang Yujing , Kan Chen 
Published: August 2023

Abstract
Metamaterials are designed with intricate geometries to deliver unique properties, and recent years have witnessed an upsurge in leveraging additive manufacturing (AM) to produce metamaterials. However, the frequent occurrence of geometric defects in AM poses a critical obstacle to realizing the desired properties of fabricated metamaterials. Advances in three-dimensional (3D) scanning technologies enable the capture of fine-grained 3D geometric patterns, thereby providing a great opportunity for detecting geometric defects in fabricated metamaterials for property-oriented quality assurance. Realizing the full potential of 3D scanning-based quality control hinges largely on devising effective approaches to process scanned point clouds and extract geometric-pertinent information. In this study, a novel framework is developed to integrate recurrence network-based 3D geometry profiling with deep one-class learning for geometric defect detection in AM of metamaterials. First, we extend existing recurrence network models that focus on image data to represent 3D point clouds, by designing a new mechanism that characterizes points’ geometric pattern affinities and spatial proximities. Then, a one-class graph neural network (GNN) approach is tailored to uncover topological variations of the recurrence network and detect anomalies associated with geometric defects in the fabricated metamaterial. The developed methodology is evaluated through comprehensive simulated and real-world case studies. Experimental results have highlighted the efficacy of the developed methodology in identifying both global and local geometric defects in AM-fabricated metamaterials.
Simulating the Adoption and Social Impact of Improved Cookstoves in Uganda Using Agent-Based Modeling and Neural Networks
Authors: Mabey Christopher S. , Peiffer Erin E. , MacCarty Nordica , Mattson Christopher A. 
Published: August 2023

Abstract
This paper presents a methodology for predicting a product’s adoption and social impact using agent-based modeling (ABM) and neural networks to aid in decision-making related to the design and implementation of the product in a sociotechnical system. The collection of primary data on the social impact of a product is also outlined. Although this paper illustrates the method for improved cookstoves in Uganda, the general method can be applied to a wide range of contexts. A field study was carried out in Uganda, consisting of two phases of data collection. The data from the field work were used to train a neural network to predict if an individual would adopt an improved cookstove. Data collected from surveys and the trained adoption model were used to create an ABM to estimate adoption rates and social impacts experienced by households that had adopted technology and to assess social impact indicators. The contributions of this article are a method for collecting primary social impact data on a product and how to integrate those data into a predictive agent-based social impact model. This methodology also enables the examination of leverage points in the sociotechnical system to improve the social impact of a product as it is implemented in society.
Concussion Incidence and Recovery of Neurocognitive Dysfunction Among Youth Athletes Taking Antibiotics: A Preliminary, Multicenter Retrospective Cohort Study
Authors: Asghar Nek , Ali Muhammad , Hannah Theodore , Li Adam Y. , Asfaw Zerubabbel , Hrabarchuk Eugene I. , Quinones Addison , McCarthy Lily , Vasan Vikram , Murtaza-Ali Muhammad , Lin Anthony , Alasadi Husni , Nakadar Zaid , Schupper Alexander J. , Gometz Alex , Lovell Mark R. , Choudhri Tanvir F. 
Published: August 2023

Concussions are the leading cause of injury among youth athletes, and antibiotics are the most prescribed pediatric medication in the United States. Antibiotics have shown to exert neuroprotective effects in animal models of traumatic brain injury, but to date, no human studies exist. Between 2009 and 2019, 6,343 adolescent athletes with differential antibiotic use at baseline were administered Immediate Post-concussion Assessment and Cognitive Testing at baseline and twice postinjury. Chronic antibiotic use was associated with a reduced risk for concussion (odds ratio 0.54), increased postconcussive symptomology and neurocognitive burden, and improved recovery by follow-up, a median of 7 days after concussion. This preliminary retrospective analysis suggests antibiotic use may impart neuroprotection up to a certain severity threshold, leading to fewer, yet more severe concussions that tend to recover faster.