bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the potential prophylactic and therapeutic effects of kaempferol on experimental Trichinella spiralis infection
Authors: Abo Maged A.I. , Metwally K.M. , El-Menyawy H.M. , Hegab F. , El-Wakil E.S. 
Published: April 2023

Abstract
Currently, no effective treatment is available for trichinellosis, a zoonotic parasitic disease caused by infection with the genus Trichinella. Kaempferol (KPF), a dietary flavonoid, has been documented to have anti-parasitic effects and various medicinal uses. Thus, this study aimed to investigate the efficacy of KPF in preventing and treating the intestinal and muscular phases of trichinellosis in mice compared with albendazole (ABZ). To achieve this, mice were divided into six groups: negative control; positive control; KPF prophylaxis; KPF treatment; ABZ treatment; and a combination of ABZ and KPF. Parasitological, histopathological and immunohistochemical evaluations were conducted to assess the effectiveness of the treatments. The parasitological assessment involved counting small intestinal adult worms and encysted muscle larvae. Additionally, the histopathological evaluation used the haematoxylin and eosin staining method for intestinal and muscular sections and picrosirius red stain for muscular sections. Moreover, the immunohistochemical expression of the intestinal NOD-like receptor-pyrin domain containing 3 (NLRP3) was evaluated. The group treated with combined drugs demonstrated a statistically significant reduction in the count of adults and encysted larvae (P < 0.05), a remarkable improvement in the inflammation of the intestines and muscles and a decrease in the thickness of the larvae's capsular layer. Additionally, the highest reduction in NLRP3 expression was observed in this group. Based on this study, KPF shows promise as an anti-trichinellosis medication that, when taken with ABZ, has a synergistic impact by modulating inflammation and larval capsule formation.
Religion, hypocrisy, and betting on secularity: reversing Smilansky's wager
Authors: Lebens Samuel , Statman Daniel 
Published: April 2023

AbstractSaul Smilansky presents us with a puzzle which, in combination with a small number of premises, is supposed to generate a reversal of Pascal's wager: the wagerer should bet on a secular lifestyle, and reject religion, as the surest way of pleasing God (if God exists). In this article, we argue that the puzzle, once unpacked, isn't particularly puzzling, that the premises aren't true, and that Smilansky's wager is open to both reductio and a reversal of its own.
The need for increased protection of Antarctica's inland waters
Authors: Hawes Ian , Howard-Williams Clive , Gilbert Neil , Hughes Kevin A. , Convey Peter , Quesada Antonio 
Published: April 2023

AbstractProtection of Antarctica's biodiversity and ecosystem values is enshrined in the Protocol on Environmental Protection to the Antarctic Treaty, which provides for the designation of Antarctic Specially Protected Areas (ASPAs) to areas with outstanding values. Concern has been raised that existing ASPAs fail to prioritize areas to maximize the likelihood of ensuring the long-term conservation of Antarctic ecosystems and biodiversity. The absence of systematic and representative protection is particularly acute for inland aquatic ecosystems, which support a disproportionate amount of inland biodiversity. This paper promotes the case for overt inclusion of inland waters as a critical component of a representative protected area framework for Antarctica, thereby addressing their current underrepresentation. We set out a structured approach to enable the selection of representative freshwater systems for inclusion in the ASPA framework that, with modification, could also be applied across other Antarctic habitats. We acknowledge an overall lack of information on the biogeography of inland aquatic diversity and recommend increased use of remote data collection along with classification tools to mitigate this, as well as the need for the consideration of catchment-scale processes. Changes that accompany contemporary and anticipated climate change make the need for the conservation of representative biodiversity increasingly urgent.
Prediction of subglacial lake melt source regions from site characteristics
Authors: Willcocks Simon , Hasterok Derrick 
Published: April 2023

AbstractSubglacial melt has important implications for ice-sheet dynamics. Locating and identifying subglacial lakes are expensive and time-consuming, requiring radar surveys or satellite methods. We explore three methods to identify source regions for lakes using seven continent-wide environmental characteristics that are sensitive to or influenced by ice-sheet temperature. A simple comparison of environmental properties at lake locations with their continent-wide distributions suggests a statistical relationship (high Kolmogorov-Smirnov statistic) between stable lake locations and ice thickness and surface temperatures, indicating melting under passive conditions. Active lakes, in contrast, show little correlation with direct thermally influenced parameters, instead exhibiting large statistical differences with horizontal velocity and bedrock elevation. More sophisticated techniques, including principal component analysis (PCA) and machine learning (ML) classification, provide better spatial identification of lake types. Positive PCA scores derived from the environmental characteristics correlate with stable lakes, whereas negative values correspond to active lakes. ML methods can also identify regions where subglacial lake melt sources are probable. While ML provides the most accurate classification maps, the combination of approaches adds deeper knowledge of the primary controls on lake formation and the environmental settings in which they are likely to be found.
The Maya 819-Day Count and Planetary Astronomy
Authors: Linden John H. , Bricker Victoria R. 
Published: April 2023

AbstractArguably the most enigmatic of the Maya calendar cycles, the 819-day count has challenged modern scholars for decades. Even today it is not completely explained and there are several areas for further research, including its relationship with the synodic periods of the planets visible to the naked eye. Earlier research has demonstrated a four-part, color-directional scheme for the 819-day count such that each of the calendar stations progress in increments of 819 days in cycles of 4 × 819 days. Although prior research has sought to show planetary connections for the 819-day count, its four-part, color-directional scheme is too short to fit well with the synodic periods of the visible planets. By increasing the calendar length to 20 periods of 819-days a pattern emerges in which the synodic periods of all the visible planets commensurate with station points in the larger 819-day calendar.
Determining food industry compliance to mandatory sodium limits: successes and challenges from the South African experience
Authors: van der Westhuizen Bianca , Frank Tamryn , Abdool Karim Safura , Swart Rina Elizabeth C 
Published: April 2023

AbstractObjective:To provide an update on the compliance to the Na reduction regulation (R.214) and to highlight some challenges and successes experienced by South Africa in the implementation of a mandatory Na regulation.Design:The study design was observational. Nutritional information of packaged food (specified in the R.214 regulation) was collected between February 2019 and September 2020, before and after the implementation date of the final Na targets in the regulation. Six supermarket chains that accounted for more than 50 % of the grocery retailer market share in South Africa were included. The Na content (per 100 g) of products was extracted from photographs. Products were classified according to the thirteen food categories included in R.214. The percentage of targeted food categories that met the pre and post-regulation targets as well as the percentage by which Na limits were exceeded was calculated.Setting:Low-and-middle-income suburbs in Cape Town, South Africa.Participants:N/A.Results:A total number of 3278 products were analysed. After the final implementation date, none of the categories targeted by the R.214 regulation fully complied. However, nine out of the thirteen food categories targeted by R.214 were above the 70 % compliance mark.Conclusions:The compliance to R.214 in South Africa is good, although not 100 % compliant. This research also highlights the complexities regarding the monitoring and evaluation of a national regulation. Findings from the current study could aid by providing valuable information to countries in the process of implementing a Na reduction strategy.
The relationship between nursing students’ compassion competencies and perceptions of spirituality and spiritual care
Authors: Dincer Aytap , Çiftçi Bahar 
Published: April 2023

AbstractObjectivesThe present study was conducted to examine the relationship between nursing students’ compassion competencies and their perceptions of spirituality and spiritual care.MethodsThe population of the study consisted of nursing students over the age of 18 years who were educated at the nursing faculty of a state university in Turkey between May and June 2022. The study was completed with 263 student nurses. The “Sociodemographic Characteristics Form,” “Compassion Competency Scale,” and “Spirituality and Spiritual Care Rating Scale” were used to collect the data. Frequencies, percentages, mean values, standard deviations, and Pearson Correlation Analysis were used to evaluate the data.ResultsThe nursing students were found to have a high level of compassion competency (4.04 ± 0.57). It was also found that the students had moderate (54.76 ± 5.35) perceptions of spirituality and spiritual care. On the other hand, there was a moderate and positive relationship between the total mean scores of “Compassion Competency” and “Perceptions of Spirituality and Spiritual Care” (p > 0.05).Significance of resultsIt was concluded that as nursing students’ compassion competencies increased, their perceptions of spirituality and spiritual care also increased.
Reducing the Spring Barrier in Predicting Summer Arctic Sea Ice Concentration
Authors: Zeng Jingwen , Yang Qinghua , Li Xuewei , Yuan Xiaojun , Bushuk Mitchell , Chen Dake 
Published: April 2023

AbstractThe predictive skill of summer sea ice concentration (SIC) in the Arctic presents a steep decline when initialized before June, which is the so‐called spring predictability barrier for Arctic sea ice. This study explores the potential influence of surface heat flux, cloud and water vapor anomalies on monthly to seasonal predictions of Arctic SIC anomalies. The results show an enhancement in skill predicting Arctic September SIC in the models that use surface fluxes, clouds, or water vapor in combination with SIC and surface sea temperature as predictors when initialized in boreal spring. This result shows the potential to reduce the spring barrier for Arctic SIC predictions by including the surface heat budget. The enhanced predictive skill can be very likely linked to the improved representation of the thermodynamics associated with water vapor and cloudiness anomalies in spring.
Airborne Remote Sensing of Upper‐Ocean and Surface Properties, Currents and Their Gradients From Meso to Submesoscales
Authors: Lenain Luc , Smeltzer Benjamin K. , Pizzo Nick , Freilich Mara , Colosi Luke , Ellingsen Simen Å. , Grare Laurent , Peyriere Hugo , Statom Nick 
Published: April 2023

AbstractIn this work we present a unique set of coincident and collocated high‐resolution observations of surface currents and directional properties of surface waves collected from an airborne instrument, the Modular Aerial Sensing System, collected off the coast of Southern California. High‐resolution observations of near surface current profiles and shear are obtained using a new instrument, “DoppVis”, capable of capturing horizontal spatial current variability down to 128 m resolution. This data set provides a unique opportunity to examine how currents at scales ranging from 1 to 100 km modulate bulk (e.g., significant wave height), directional and spectral properties of surface gravity waves. Such observations are a step toward developing better understanding of the underlying physics of submesoscale processes (e.g., frontogenesis and frontal arrest) and the nature of transitions between mesoscale and submesoscale dynamics.
Seismic Source Characterization From GNSS Data Using Deep Learning
Authors: Costantino Giuseppe , Giffard‐Roisin Sophie , Marsan David , Marill Lou , Radiguet Mathilde , Mura Mauro Dalla , Janex Gaël , Socquet Anne 
Published: April 2023

AbstractThe detection of deformation in Global Navigation Satellite System (GNSS) time series associated with (a)seismic events down to a low magnitude is still a challenging issue. The presence of a considerable amount of noise in the data makes it difficult to reveal patterns of small ground deformation. Traditional analyses and methodologies are able to effectively retrieve the deformation associated with medium to large magnitude events. However, the automatic detection and characterization of such events is still a complex task, because traditionally employed methods often separate the time series analysis from the source characterization. Here we propose a first end‐to‐end framework to characterize seismic sources using geodetic data by means of deep learning, which can be an efficient alternative to the traditional workflow, possibly overcoming its performance. We exploit three different geodetic data representations in order to leverage the intrinsic spatio‐temporal structure of the GNSS noise and the target signal associated with (slow) earthquake deformation. We employ time series, images, and image time series to account for the temporal, spatial, and spatio‐temporal domain, respectively. Thereafter, we design and develop a specific deep learning model for each dataset. We analyze the performance of the tested models both on synthetic and real data from North Japan, showing that image time series of geodetic deformation can be an effective data representation to embed the spatio‐temporal evolution, with the associated deep learning method outperforming the other two. Therefore, jointly accounting for the spatial and temporal evolution may be the key to effectively detect and characterize fast or slow earthquakes.
Vertical‐Slice Ocean Tomography With Seismic Waves
Authors: Callies Jörn , Wu Wenbo , Peng Shirui , Zhan Zhongwen 
Published: April 2023

AbstractSeismically generated sound waves that propagate through the ocean are used to infer temperature anomalies and their vertical structure in the deep East Indian Ocean. These T waves are generated by earthquakes off Sumatra and received by hydrophone stations off Diego Garcia and Cape Leeuwin. Between repeating earthquakes, a T wave's travel time changes in response to temperature anomalies along the wave's path. What part of the water column the travel time is sensitive to depends on the frequency of the wave, so measuring travel time changes at a few low frequencies constrains the vertical structure of the inferred temperature anomalies. These measurements reveal anomalies due to equatorial waves, mesoscale eddies, and decadal warming trends. By providing direct constraints on basin‐scale averages with dense sampling in time, these data complement previous point measurements that alias local and transient temperature anomalies.
The role of HDAC3 and its inhibitors in regulation of oxidative stress and chronic diseases
Authors: He Ruyuan , Liu Bohao , Geng Boxin , Li Ning , Geng Qing 
Published: April 2023

AbstractHDAC3 is a specific and crucial member of the HDAC family. It is required for embryonic growth, development, and physiological function. The regulation of oxidative stress is an important factor in intracellular homeostasis and signal transduction. Currently, HDAC3 has been found to regulate several oxidative stress-related processes and molecules dependent on its deacetylase and non-enzymatic activities. In this review, we comprehensively summarize the knowledge of the relationship of HDAC3 with mitochondria function and metabolism, ROS-produced enzymes, antioxidant enzymes, and oxidative stress-associated transcription factors. We also discuss the role of HDAC3 and its inhibitors in some chronic cardiovascular, kidney, and neurodegenerative diseases. Due to the simultaneous existence of enzyme activity and non-enzyme activity, HDAC3 and the development of its selective inhibitors still need further exploration in the future.
Male delayed orgasm and anorgasmia: a practical guide for sexual medicine providers
Authors: Nguyen Vi , Dolendo Isabella , Uloko Maria , Hsieh Tung-Chin , Patel Darshan 
Published: April 2023

AbstractDelayed orgasm (DO) is defined as increased latency of orgasm despite adequate sexual stimulation and desire. Anorgasmia (AO) is characterized as the absence of orgasm. Etiologies of DO/AO include medication-induced, psychogenic, endocrine, and genitopelvic dysesthesia. Given the multifactorial complex nature of this disorder, a thorough history and physical examination represent the most critical components of patient evaluation in the clinical setting. Treating DO/AO can be challenging due to the lack of standardized FDA-approved pharmacotherapies. There is no standardized treatment plan for DO/AO, though common treatments plans are often multidisciplinary and may include adjustment of offending medications and sex therapy. In this review, we summarize the etiology, diagnosis, and treatment of DO/AO.
The value of ecosystem services in global marine kelp forests
Authors: Eger Aaron M. , Marzinelli Ezequiel M. , Beas-Luna Rodrigo , Blain Caitlin O. , Blamey Laura K. , Byrnes Jarrett E. K. , Carnell Paul E. , Choi Chang Geun , Hessing-Lewis Margot , Kim Kwang Young , Kumagai Naoki H. , Lorda Julio , Moore Pippa , Nakamura Yohei , Pérez-Matus Alejandro , Pontier Ondine , Smale Dan , Steinberg Peter D. , Vergés Adriana 
Published: April 2023

AbstractWhile marine kelp forests have provided valuable ecosystem services for millennia, the global ecological and economic value of those services is largely unresolved. Kelp forests are diminishing in many regions worldwide, and efforts to manage these ecosystems are hindered without accurate estimates of the value of the services that kelp forests provide to human societies. Here, we present a global estimate of the ecological and economic potential of three key ecosystem services - fisheries production, nutrient cycling, and carbon removal provided by six major forest forming kelp genera (Ecklonia, Laminaria, Lessonia, Macrocystis, Nereocystis, and Saccharina). Each of these genera creates a potential value of between $64,400 and $147,100/hectare each year. Collectively, they generate between $465 and $562 billion/year worldwide, with an average of $500 billion. These values are primarily driven by fisheries production (mean $29,900, 904 Kg/Ha/year) and nitrogen removal ($73,800, 657 Kg N/Ha/year), though kelp forests are also estimated to sequester 4.91 megatons of carbon from the atmosphere/year highlighting their potential as blue carbon systems for climate change mitigation. These findings highlight the ecological and economic value of kelp forests to society and will facilitate better informed marine management and conservation decisions.
Hybrid photoacoustic and fast super-resolution ultrasound imaging
Authors: Zhao Shensheng , Hartanto Jonathan , Joseph Ritin , Wu Cheng-Hsun , Zhao Yang , Chen Yun-Sheng 
Published: April 2023

AbstractThe combination of photoacoustic (PA) imaging and ultrasound localization microscopy (ULM) with microbubbles has great potential in various fields such as oncology, neuroscience, nephrology, and immunology. Here we developed an interleaved PA/fast ULM imaging technique that enables super-resolution vascular and physiological imaging in less than 2 seconds per frame in vivo. By using sparsity-constrained (SC) optimization, we accelerated the frame rate of ULM up to 37 times with synthetic data and 28 times with in vivo data. This allows for the development of a 3D dual imaging sequence with a commonly used linear array imaging system, without the need for complicated motion correction. Using the dual imaging scheme, we demonstrated two in vivo scenarios challenging to image with either technique alone: the visualization of a dye-labeled mouse lymph node showing nearby microvasculature, and a mouse kidney microangiography with tissue oxygenation. This technique offers a powerful tool for mapping tissue physiological conditions and tracking the contrast agent biodistribution non-invasively.
Thermal tolerance of perovskite quantum dots dependent on A-site cation and surface ligand
Authors: Wang Shuo , Zhao Qian , Hazarika Abhijit , Li Simiao , Wu Yue , Zhai Yaxin , Chen Xihan , Luther Joseph M. , Li Guoran 
Published: April 2023

AbstractA detailed picture of temperature dependent behavior of CsxFA1-xPbI3 perovskite quantum dots across the composition range is constructed by performing in situ optical spectroscopic and structural measurements, supported by theoretical calculations that focus on the relation between A-site chemical composition and surface ligand binding. The thermal degradation mechanism depends not only on the exact chemical composition, but also on the ligand binding energy. The thermal degradation of Cs-rich perovskite quantum dots is induced by a phase transition from black γ-phase to yellow δ-phase, while FA-rich perovskite quantum dots with higher ligand binding energy directly decompose into PbI2. Quantum dot growth to form large bulk size grain is observed for all CsxFA1-xPbI3 perovskite quantum dots at elevated temperatures. In addition, FA-rich quantum dots possess stronger electron−longitudinal optical phonon coupling, suggesting that photogenerated excitons in FA-rich quantum dots have higher probability to be dissociated by phonon scattering compared to Cs-rich quantum dots.
A low-carbon electricity sector in Europe risks sustaining regional inequalities in benefits and vulnerabilities
Authors: Sasse Jan-Philipp , Trutnevyte Evelina 
Published: April 2023

AbstractImproving equity is an emerging priority in climate and energy strategies, but little is known how these strategies would alter inequalities. Regional inequalities such as price, employment and land use are especially relevant in the electricity sector, which must decarbonize first to allow other sectors to decarbonize. Here, we show that a European low-carbon electricity sector in 2035 can reduce but also sustain associated regional inequalities. Using spatially-explicit modeling for 296 sub-national regions, we demonstrate that emission cuts consistent with net-zero greenhouse gas emissions in 2050 result in continent-wide benefits by 2035 regarding electricity sector investments, employment gains, and decreased greenhouse gas and particulate matter emissions. However, the benefits risk being concentrated in affluent regions of Northern Europe, while regions of Southern and Southeastern Europe risk high vulnerabilities due to high adverse impacts and sensitivities, and low adaptive capacities. Future analysis should investigate policy mechanisms for reducing and compensating inequalities.
Negative magnetostrictive paper formed by dispersing CoFe2O4 particles in cellulose nanofibrils
Authors: Keino Takumi , Rova Lovisa , Gallet--Pandellé Alia , Kurita Hiroki , Narita Fumio 
Published: April 2023

AbstractPolymers are often combined with magnetostrictive materials to enhance their toughness. This study reports a cellulose nanofibril (CNF)-based composite paper containing dispersed CoFe2O4 particles (CNF–CoFe2O4). Besides imparting magnetization and magnetostriction, the incorporation of CoFe2O4 particles decreased the ultimate tensile strength and increased the fracture elongation of the CNF–CoFe2O4 composite paper. CNF was responsible for the tensile properties of CNF–CoFe2O4 composite paper. Consequently, the magnetic and magnetostrictive properties and tensile properties of CNF–CoFe2O4 composite paper can be controlled by changing the mixture ratio of CNF and CoFe2O4 particles.