bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shear‐Responsive Drug Delivery Systems in Medical Devices: Focus on Thrombosis and Bleeding
Authors: Zeibi Shirejini Saeedreza , Carberry Josie , Alt Karen , Gregory Shaun D , Hagemeyer Christoph E 
Published: June 2023

AbstractCardiovascular disease is the leading cause of death worldwide. Blood‐contacting medical devices provide critical support for patients with severe respiratory and/or cardiac failure. High shear stress zones and non‐biocompatible circuit can increase the risk of thrombus formation in patients. These thrombi restrict blood flow through the circuits and travel to the lungs and brain, creating significant consequences. Antithrombotic drugs are used to lower this risk, but they also raise the incidence of bleeding problems. This article explores the delicate balance between thrombosis and bleeding in medical devices by examining platelet activation and thrombosis formation under shear stress. The feasibility of a shear‐responsive nanomedicine‐based drug delivery system has been explored as a potential approach for targeted administration of antithrombotic medications to lower systemic drug levels and reduce the bleeding risk. Furthermore, the lack of in vitro platforms to investigate the biological behavior of antithrombotic nanoparticles is impeding their clinical translation. As a result, microfluidic technology offers a platform for investigating nanoparticle behavior in vitro and linking it to their performance in vivo. Finally, the challenges and factors that affect the functionality, stability, and circulation time of liposomal drugs are investigated to improve their efficacy for targeted drug administration in medical devices.
Photocrosslinkable Zwitterionic Ligands for Perovskite Nanocrystals: Self‐Assembly and High‐Resolution Direct Patterning
Authors: Noh Sung Hoon , Jeong WonJo , Lee Kyeong Ho , Yang Han Sol , Suh Eui Hyun , Jung Jaemin , Park Seul Chan , Lee Dongwoon , Jung In Hwan , Jeong Yong Jin , Jang Jaeyoung 
Published: June 2023

AbstractPerovskite nanocrystals (PNCs) are attractive photoactive materials in various optoelectronic devices including light‐emitting diodes, solar cells, and photodetectors. However, the weakly bound surface ligands on PNCs reduce colloidal stability and cause film formation and patterning difficulties, severely restricting their practical applications. Herein, a rationally designed photocrosslinkable zwitterionic (PZ) ligand is introduced to obtain directly patternable CsPbBr3 PNCs with enhanced colloidal stability, optical properties, and self‐assembly propensity. The PZ ligands strongly interact with the pre‐synthesized PNCs in solution, substantially replacing the original capping ligands and effectively passivating surface defects. This surface engineering induces strong electrostatic interactions between the PNCs, enabling the fabrication of densely packed CsPbBr3 PNC films. Furthermore, the methacrylate group of the PZ ligands serves as a bridge for active radical propagation in the ligand shells around the PNCs upon UV exposure. Accordingly, high‐resolution direct photopatterning can be achieved through ligand crosslinking, and the resulting PNC patterns (minimum line spacing of 4 µm) maintain optical stability for over 2 weeks. Therefore, this study demonstrates that a tailored ligand design strategy enables the simultaneous achievement of high colloidal stability, optical properties, photopatternability, and self‐assembly propensity and has considerable potential to be extended to other PNC materials.
Human Papilloma Virus DNA Detection in Clinical Samples Using Fluorogenic Probes Based on Oligonucleotide Gated Nanoporous Anodic Alumina Films
Authors: Hernández‐Montoto Andy , Aranda M. Nieves , Caballos Isabel , López‐Palacios Alba , Tormo‐Mas María Ángeles , Pemán Javier , Rodríguez Mireya Prieto , Picornell Carlos , Aznar Elena , Martínez‐Máñez Ramón 
Published: June 2023

AbstractIn this work, fluorogenic probes based on oligonucleotide capped nanoporous anodic alumina films are developed for specific and sensitive detection of human papilloma virus (HPV) DNA. The probe consists of anodic alumina nanoporous films loaded with the fluorophore rhodamine B (RhB) and capped with oligonucleotides bearing specific base sequences complementary to genetic material of different high‐risk (hr) HPV types. Synthesis protocol is optimized for scale up production of sensors with high reproducibility. The sensors' surfaces are characterized by scanning electron microscopy (HR‐FESEM) and atomic force microscopy (AFM) and their atomic composition is determined by energy dispersive X‐ray spectroscopy (EDXS). Oligonucleotide molecules onto nanoporous films block the pores and avoid diffusion of RhB to the liquid phase. Pore opening is produced when specific DNA of HPV is present in the medium, resulting in RhB delivery, that is detected by fluorescence measurements. The sensing assay is optimized for reliable fluorescence signal reading. Nine different sensors are synthesized for specific detection of 14 different hr‐HPV types in clinical samples with very high sensitivity (100%) and high selectivity (93–100%), allowing rapid screening of virus infections with very high negative predictive values (100%).
Cascaded Nanozyme with In Situ Enhanced Photothermal Capacity for Tumor‐Specific and Self‐Replenishing Cancer Therapy
Authors: Cai Xiaoli , Liu Renyu , Yan Hongye , Jiao Lei , Sha Meng , Chen Yifeng , Rong Shuang , Liu Zhengzheng , Deng Liu , Shen Liangfang , Zhu Chengzhou 
Published: June 2023

AbstractReactive oxygen species (ROS)‐involved tumor therapeutic strategy, chemodynamic therapy (CDT), has attracted extensive research interest in the scientific community. However, the therapeutic effect of CDT is insufficient and unsustainable owing to the limited endogenous H2O2 level in the tumor microenvironment. Here, peroxidase (POD)‐like RuTe2 nanozyme with the immobilization of glucose oxidase (GOx) and allochroic 3,3′,5,5′‐tetramethylbenzidine (TMB) molecule have been synthesized to construct RuTe2‐GOx‐TMB nanoreactors (RGT NRs) as cascade reaction systems for tumor‐specific and self‐replenishing cancer therapy. GOx in sequential nanocatalysts can effectively deplete glucose in tumor cells. Meanwhile, a sustainable supply of H2O2 for subsequent Fenton‐like reactions catalyzed by RuTe2 nanozyme is achieved in response to the mild acidic tumor microenvironment. Through this cascade reaction, highly toxic hydroxyl radicals (·OH) are produced, which can further oxidize TMB to trigger tumor‐specific “turn‐on” photothermal therapy (PTT). In addition, PTT and massive ROS can stimulate the tumor immune microenvironment and activate the systematic anti‐tumor immune responses, exerting a notable effect on hindering tumor recurrence and metastasis. This study paves a promising paradigm for synergistic starvation therapy, PTT, and CDT cancer therapy with high efficiency.
N‐Acetyl‐l‐cysteine‐Derived Carbonized Polymer Dots with ROS Scavenging via Keap1‐Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis
Authors: Liu Xinchan , Hou Yubo , Yang Mingxi , Xin Xirui , Deng Yu , Fu Ruobing , Xiang Xingchen , Cao Niuben , Liu Xiaomeng , Yu Weixian , Yang Bai , Zhou Yanmin 
Published: June 2023

AbstractPeriodontitis is a type of chronic inflammatory oral disease characterized by the destruction of periodontal connective tissue and progressive alveolar bone resorption. As oxidative stress is the key cause of periodontitis in the early periodontal microenvironment, antioxidative therapy has been considered a viable treatment for periodontitis. However, more stable and effective reactive oxygen species (ROS)‐scavenging nanomedicines are still highly needed due to the instability of traditional antioxidants. Herein, a new type of N‐acetyl‐l‐cysteine (NAC)‐derived red fluorescent carbonized polymer dots (CPDs) has been synthesized with excellent biocompatibility, which can serve as an extracellular antioxidant to scavenge ROS effectively. Moreover, NAC‐CPDs can promote osteogenic differentiation in human periodontal ligament cells (hPDLCs) under H2O2 stimulation. In addition, NAC‐CPDs are capable of targeted accumulation in alveolar bone in vivo, reducing the level of alveolar bone resorption in periodontitis mice, as well as performing fluorescence imaging in vitro and in vivo. In terms of mechanism, NAC‐CPDs may regulate redox homeostasis and promote bone formation in the periodontitis microenvironment by modulating the kelch‐like ECH‐associated protein l (Keap1)/nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway. This study provides a new strategy for the application of CPDs theranostic nanoplatform for periodontitis.
A Monolayer High‐Entropy Layered Hydroxide Frame for Efficient Oxygen Evolution Reaction
Authors: Ding Yiran , Wang Zhouyang , Liang Zijia , Sun Xueping , Sun Zihang , Zhao Yuanxin , Liu Junlin , Wang Chenyang , Zeng Ziyue , Fu Lei , Zeng Mengqi , Tang Lin 
Published: June 2023

AbstractHigh‐entropy materials with tailored geometric and elemental compositions provide a guideline for designing advanced electrocatalysts. Layered double hydroxides (LDHs) are the most efficient oxygen evolution reaction (OER) catalyst. However, due to the huge difference in ionic solubility product, an extremely strong alkali environment is necessary to prepare high‐entropy layered hydroxides (HELHs), which results in an uncontrollable structure, poor stability, and scarce active sites. Here, a universal synthesis of monolayer HELH frame in a mild environment is presented, regardless of the solubility product limit. Mild reaction conditions allow this study to precisely control the fine structure and elemental composition of the final product. Consequently, the surface area of the HELHs is up to 380.5 m2 g−1. The current density of 100 mA cm−2 is achieved in 1 m KOH at an overpotential of 259 mV, and, after 1000 h operation at the current density of 20 mA cm−2, the catalytic performance shows no obvious deterioration. The high‐entropy engineering and fine nanostructure control open opportunities to solve the problems of low intrinsic activity, very few active sites, instability, and low conductance during OER for LDH catalysts.
A T Cell‐Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy
Authors: Zhou Zhuolong , Van der Jeught Kevin , Li Yujing , Sharma Samantha , Yu Tao , Moulana Ishara , Liu Sheng , Wan Jun , Territo Paul R. , Opyrchal Mateusz , Zhang Xinna , Wan Guohui , Lu Xiongbin 
Published: June 2023

AbstractPancreatic ductal adenocarcinoma (PDA) is a clinically challenging disease with limited treatment options. Despite a small percentage of cases with defective mismatch DNA repair (dMMR), PDA is included in the most immune‐resistant cancer types that are poorly responsive to immune checkpoint blockade (ICB) therapy. To facilitate drug discovery combating this immunosuppressive tumor type, a high‐throughput drug screen platform is established with the newly developed T cell‐incorporated pancreatic tumor organoid model. Tumor‐specific T cells are included in the pancreatic tumor organoids by two‐step cell packaging, fully recapitulating immune infiltration in the immunosuppressive tumor microenvironment (TME). The organoids are generated with key components in the original tumor, including epithelial, vascular endothelial, fibroblast and macrophage cells, and then packaged with T cells into their outside layer mimicking a physical barrier and enabling T cell infiltration and cytotoxicity studies. In the PDA organoid‐based screen, epigenetic inhibitors ITF2357 and I‐BET151 are identified, which in combination with anti‐PD‐1 based therapy show considerably greater anti‐tumor effect. The combinatorial treatment turns the TME from immunosuppressive to immunoactive, up‐regulates the MHC‐I antigen processing and presentation, and enhances the effector T cell activity. The standardized PDA organoid model has shown great promise to accelerate drug discovery for the immunosuppressive cancer.
Zirabia cylindrica comb. nov. provides evidence of Doyleales in the Jurassic
Authors: Elgorriaga Andres , Atkinson Brian A. 
Published: June 2023

AbstractPremiseIn recent years, Doyleales have played an important role in the discussion and exploration of seed plant relationships and the origin of angiosperms. This order comprises a diversity of recently described genera with cupule‐bearing compound ovulate cones recovered from Early Cretaceous deposits in North America and Asia. Their relatively late appearance in the fossil record, stratigraphically near the appearance of angiosperms in the Early Cretaceous, has been noteworthy. Here, we report a new genus of Doyleales, Zirabia gen. nov. from the Early Jurassic of Iran, that was originally described as the ginkgophyte Karkenia.MethodsWe reinvestigated material previously assigned to Karkenia cylindrica from the Lower Jurassic of the Zirab locality, Alborz Mountains, northern Iran.ResultsThe studied specimen features a main axis bearing helically to irregularly arranged bract‐cupule complexes, each composed by a long laminar bract subtending and sheathing a cupule stalk that bears a single‐seeded cupule with a dorsal protrusion. The morphological features of this taxon do not conform with those of Karkenia, and suggest affinities with Doyleales rather than Ginkgoales. Within Doyleales, this fossil has a unique combination of characters indicating that it is a new genus within the order; thus, a new combination is erected, Zirabia cylindrica.ConclusionsOur results indicate that Doyleales is significantly older than previously thought, with their stratigraphic range now extending from the Lower Jurassic to the Cretaceous. The Early Jurassic occurrence of Doyleales provides important data on the emergence of seed‐enclosing structures seen in seed plants throughout the Mesozoic.
Experiences of police‐related stress among a U.S. national cohort of gay and bisexual men
Authors: Bacchus Erinn C. , D'Angelo Alexa B. , Grov Christian 
Published: June 2023

AbstractMarginalized groups (including people of Color and sexual minorities) have been over‐policed and specifically targeted based on their race/ethnicity and identity. The deleterious effects of over‐policing marginalized groups include overrepresentation in the carceral system, experiencing higher rates of violence from police, and extend to affect mental health and stress levels. This study examines police‐related stress among a U.S. national cohort of gay and bisexual men (collected in late 2020 and early 2021) and its association with race/ethnicity, age, human immunodeficiency virus (HIV) status, income, and other characteristics of interest. Our results show that the odds of reporting extreme police‐related stress were 2.7 (95% confidence interval [CI] [2.08, 3.41]) times higher for Black individuals than for their White counterparts. Odds were also significantly greater for those who have experienced race‐based (odds ratio [OR] = 2.26, 95% CI [1.81–2.82] or identity‐based discrimination (OR = 2.05, 95% CI [1.66, 2.54]). Our findings demonstrate variation in police‐related stress among a cohort of gay and bisexual men; with men of Color and low‐income men among the most affected by police‐related stress. For this population, police‐related stress should be considered for its potential deleterious effect on HIV vulnerability and reporting violent crimes to police (including intimate partner violence and hate crimes).
Efficient Cross‐Dehydrogenative Coupling (CDC) Enabled by Cu‐PMo12 towards the Synthesis of Pyrimidinyl Carbamates at Room Temperature
Authors: Gaware Sujeet , Chatterjee Rana , Kotkondawar Abhay Vijay , Dandela Rambabu 
Published: June 2023

AbstractA novel and efficient approach has been developed for the direct synthesis of pyrimidinyl dimethylcarbamate using Cu‐PMo12 complex. Basically, Cu‐PMA catalyst successfully enabled the cross‐dehydrogenative coupling (CDC) reaction between N‐benzoyl cytosine and formamides in the presence of tert‐butyl hydroperoxide and triethyl amine. Herein, Cu(I/II) catalytic system facilitated the oxidative coupling of the carbamide function, generating a new C−O bond and has been identified as more efficient compared to other commercially available Cu (I) or Cu (II) salts. Furthermore, the characterization of the catalyst was performed by XPS, SEM and EDX analysis. The present method also demonstrates a simple procedure with least catalyst loading, a wide variety of substrates with excellent functional group compatibility, high yields, ambient conditions, and operational simplicity.
Preparedness of China's health care system to provide access to a disease‐modifying Alzheimer's treatment
Authors: Mattke Soeren , Loh Wei Kok , Yuen Kah‐Hung , Yoong Joanne 
Published: June 2023

AbstractINTRODUCTIONAlthough the majority of patients with Alzheimer's disease (AD) reside in low‐and middle‐income countries, little is known of the infrastructure in these countries for delivering emerging disease‐modifying treatments.METHODSWe analyze the preparedness of China, the world's most populous middle‐income country, using desk research, expert interviews and a simulation model.RESULTSOur findings suggest that China's health care system is ill‐prepared to provide timely access to Alzheimer's treatment. The current pathway, in which patients seek evaluation in hospital‐based memory clinics without a prior assessment in primary care, would overwhelm existing capacity. Even with triage using a brief cognitive assessment and a blood test for the AD pathology, predicted wait times would remain over 2 years for decades, largely due to limited capacity for confirmatory biomarker testing despite adequate specialist capacity.DISCUSSIONClosing this gap will require the introduction of high‐performing blood tests, greater reliance on cerebrospinal fluid (CSF) testing, and expansion of positron emission tomography (PET) capacity.
Dual Atom Catalysts for Energy and Environmental Applications
Authors: Pu Tiancheng , Ding Jiaqi , Zhang Fanxing , Wang Ke , Cao Ning , Hensen Emiel J. M. , Xie Pengfei 
Published: June 2023

AbstractThe pursuit of high metal utilization in heterogeneous catalysis has triggered the burgeoning interest of various atomically dispersed catalysts. Our aim in this review is to assess key recent findings in the synthesis, characterization, structure‐property relationship and computational studies of dual‐atom catalysts (DACs), which cover the full spectrum of applications in thermocatalysis, electrocatalysis and photocatalysis. In particular, combination of qualitative and quantitative characterization with cooperation with DFT insights, synergies and superiorities of DACs compare to counterparts, high‐throughput catalyst exploration and screening with machine‐learning algorithms are highlighted. Undoubtably, it would be wise to expect more fascinating developments in the field of DACs as tunable catalysts.
Total Synthesis of Illisimonin A and Merrilactone A
Authors: Gong Xu , Huang Juan , Sun Xiangrui , Chen Ziling , Yang Ming 
Published: June 2023

AbstractIllicium sesquiterpenes are a large family of biologically active secondary metabolites isolated from Illicium species of plants and are well‐known for their activity of neurite outgrowth in cultured neurons. Herein, we propose a comprehensive biosynthetic pathway for illicium sesquiterpenes and report a synthetic route to illisimonin A and merrilactone A based on it. We think that the carbon scaffolds of most of the illicium sesquiterpenes could be synthesized from a dicarbonyl derivative of allo‐cedrane through retro‐Dieckmann condensation, oxidative cleavage and aldol reaction at suitable oxidation states in Nature. The common intermediate for illisimonin A and merrilactone A similar to the dicarbonyl derivative of allo‐cedrane was assembled with up to 82 % ee by an asymmetric intramolecular desymmetrizing reductive Heck reaction by the use of a new type of chiral phosphine ligand. The syntheses of illisimonin A and merrilactone A supported the key transformations of the proposed biosynthetic pathway.
Cobalt‐Catalyzed Regiodivergent Ring‐Opening Dihydroboration of Arylidenecyclopropanes to Access Skipped Diboronates
Authors: Tan Boon Beng , Hu Ming , Ge Shaozhong 
Published: June 2023

AbstractLigand‐controlled regiodivergent cobalt‐catalyzed ring‐opening dihydroboration of arylidenecyclopropanes is developed to access synthetically versatile skipped diboronates with catalysts generated in situ from Co(acac)2 and dpephos or xantphos. A variety of arylidenecyclopropanes reacted with pinacolborane (HBpin) to form the corresponding 1,3‐ or 1,4‐diboronates in high isolated yields and with high regioselectivity. Skipped diboronate products from these reactions can undergo various transformations to allow selective installation of two different functional groups along alkyl chains. Mechanistic studies suggest that these reactions combine cobalt‐catalyzed ring‐opening hydroboration of arylidenecyclopropanes and hydroboration of homoallylic or allylic boronate intermediates.
Antisemitism: A psychoanalytic theory
Authors: White Robert S. 
Published: June 2023

AbstractAntisemitism has been a persistent and growing prejudice for millenniums against the Jewish people. This paper offers a general theory of group hatred appliable to antisemitism and other religious or racial prejudices. Theories of prejudice tend either to postulate an internal psychic template of hatred that is projected or postulate a social origin of hatred that is internalized. Rather there is a dialectic where there is a reciprocal movement between internal and external. The tendency to hate and project is a part of the human psyche, here called internal racism. Anxieties which cannot be contained internally can be stabilized by large‐group identity. When internal racism cannot be contained or the external social groups are weak, the result is pathological large‐group formations. A distinction can be made between personal antisemitism in which the hatred is projected onto a known person and impersonal antisemitism in which hatred is projected into groups. A fairy tale by the brother's Grimm, “The Jew among Thorns” is used to illustrate a number of personal antisemitic attitudes. “The Protocols of the Elders of Zion,” a forged document that appeared in pre‐revolutionary Russia, is used to illustrate impersonal antisemitism.
A comparison of freezer‐stored DNA and herbarium tissue samples for chloroplast assembly and genome skimming
Authors: McAssey Edward V. , Downs Cassidy , Yorkston Mitsuko , Morden Clifford , Heyduk Karolina 
Published: June 2023

AbstractPremiseThe use of DNA from herbarium specimens is an increasingly important source for evolutionary studies in plant biology, particularly in cases where species are rare or difficult to obtain. Here we compare the utility of DNA from herbarium tissues to their freezer‐stored DNA counterparts via the Hawaiian Plant DNA Library.MethodsPlants collected for the Hawaiian Plant DNA Library were simultaneously accessioned as herbarium specimens at the time of collection, from 1994–2019. Paired samples were sequenced using short‐read sequencing and assessed for chloroplast assembly and nuclear gene recovery.ResultsHerbarium specimen–derived DNA was statistically more fragmented than freezer‐stored DNA derived from fresh tissue, leading to poorer chloroplast assembly and overall lower coverage. The number of nuclear targets recovered varied mostly by total sequencing reads per library and age of specimen, but not by storage method (herbarium or long‐term freezer). Although there was evidence of DNA damage in the samples, there was no evidence that it was related to the length of time in storage, whether frozen or as herbarium specimens.DiscussionDNA extracted from herbarium tissues will continue to be invaluable, despite being highly fragmented and degraded. Rare floras would benefit from both traditional herbarium storage methods and extracted DNA freezer banks.