bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal Therapeutic Platforms Based on Self‐Assembled Metallacycles/Metallacages for Cancer Radiochemotherapy
Authors: Li Zheng , Huan Weiwei , Wang Yan , Yang Ying‐Wei 
Published: September 2023

AbstractDiscrete organometallic complexes with defined structures are proceeding rapidly in combating malignant tumors due to their multipronged treatment modalities. Many innovative superiorities, such as high antitumor activity, extremely low systemic toxicity, active targeting ability, and enhanced cellular uptake, make them more competent for clinical applications than individual precursors. In particular, coordination‐induced regulation of luminescence and photophysical properties of organic light‐emitting ligands has demonstrated significant potential in the timely evaluation of therapeutic efficacy by bioimaging and enabled synergistic photodynamic therapy (PDT) or photothermal therapy (PTT). This review highlights instructive examples of multimodal radiochemotherapy platforms for cancer ablation based on self‐assembled metallacycles/metallacages, which would be classified by functions in a progressive manner. Finally, the essential demands and some plausible prospects in this field for cancer therapy are also presented.
Effect of aspect ratio on the aerodynamic performance and correlation of square section building exposed to twisted wind profile
Authors: Zhou Lei , Tse Kam Tim , Hu Gang , Guo Zijian 
Published: September 2023

SummaryThis study investigates the aerodynamic performance of three square‐section buildings with different aspect ratio (AR = 1:1, 1:4, and 1:6) exposed to twisted wind profile (TWP) by pressure measurement test. The effect of AR on the correlation of wind loads specifically for TWP is systematically revealed from both time–frequency domain and local–global perspective. Results show that compared with its counterparts in conventional wind profile (CWP), the effect of AR on aerodynamic load under TWP becomes significantly different and more prominent, which can be categorized into two types of patterns. For pattern low‐rise building, TWP is more resembling the condition of CWP with certain attack angle. For pattern high‐rise building, TWP results in stronger momentum exchange along building height but suppresses fluctuating feature associated with Karman vortex. As a result, under TWP, mean base moments of all buildings are enhanced except for longitudinal component of case AR = 1:4 and 1:6; while the fluctuating base moment for three AR cases is all reduced, which indicates that dynamic pattern of wake flow is suppressed. Moreover, the discrepancy of local wind load between case CWP and TWP concentrates on the lower‐middle location for high‐rise building but distributed evenly along all low‐rise building height. Additionally, it is found that the effect of AR on aerodynamic correlation exhibits different mechanisms and patterns when building is under the impact of CWP or TWP.
Fossil or non‐fossil? A best‐practice guide for archaeobotanical taxa
Authors: Rivera Diego , Ferrer‐Gallego P. Pablo , Obón Concepción , Alcaraz Francisco , Valera Javier , Goncharov Nikolay P. , Laguna Emilio , Kislev Mordechai 
Published: September 2023

AbstractCan archaeobotanical material be treated as a nomenclatural type of a fossil taxon? Here we show that archaeobotanical taxa should be named according to the rules for non‐fossil taxa. Examples of archaeobotanical taxa are summarized and discussed. A best‐practice guide for the correct treatment of archaeological plant remains as the type of a new name is presented.
The development of the Cognitive Assessment for Tagalog Speakers (CATS): A culturally and linguistically tailored test battery for Filipino Americans
Authors: de Leon Jessica , Bondoc Ivan , Mamuyac Eugenie , Posecion Lainie , Europa Eduardo , Kintanar Lolita C. , Roco Niecholle , Lamoca Mikkael , Escueta Danielle P. , Park Van M. Ta 
Published: September 2023

AbstractINTRODUCTIONFilipino Americans are one of the largest Asian American and Pacific Islander (AAPI) populations in the United States (US). Previous studies suggest that Filipino Americans have one of the highest incidence rates of Alzheimer's disease and related dementias (ADRD) among AAPI subgroups. Despite the expected increase in Filipino Americans with ADRD, no studies to‐date have validated neuropsychological measures in the United States for speakers of Tagalog, a major language spoken by Filipino Americans. A significant barrier to dementia care and diagnosis is the lack of linguistically and socioculturally appropriate cognitive tasks for Tagalog speakers. To address this need, we developed and piloted the Cognitive Assessment for Tagalog Speakers (CATS), the first neuropsychological battery for the detection of ADRD in Filipino American Tagalog speakers.METHODSBased on evidence‐based neuropsychological batteries, we adapted and constructed de novo tasks to measure performance across 4 main cognitive domains: visual/verbal memory, visuospatial functioning, speech and language, and frontal/executive functioning. Tasks were developed with a team of bilingual English/Tagalog, bicultural Filipino American/Canadian experts, including a neurologist, speech‐language pathologist, linguist, and neuropsychologist. We recruited Tagalog‐speaking participants of age 50+ through social media advertisements and recruitment registries for this cross‐sectional study. We present the CATS design and protocol.RESULTSTo‐date, the CATS battery has been administered to 26 healthy control participants (age 64.5 ± 7.8 years, 18F/8 M) at an academic institution in Northern California, United States. The development and administration of the CATS battery demonstrated its feasibility but also highlighted the need to consider the effects of bilingualism, language typology, and cultural factors in result interpretation.DISCUSSIONThe CATS battery provides a mechanism for cognitive assessment of Filipino Americans, a population that has been underrepresented in ADRD research. As we move toward the treatment and cure of ADRD, linguistically and socioculturally appropriate cognitive tests become even more important for equitable care.
Comparative effects of medium‐chain fatty acids or phytobiotics‐based feed additives on performance, caecum microbiota, volatile fatty acid production and intestinal morphology of broilers
Authors: Ceylan Necmettin , Yenice Engin , Yavaş İsmail , Çenesiz Ali Anıl , Toprak Neşe Nuray , Çiftçi İbrahim 
Published: September 2023

AbstractAntibiotic growth promoters have been utilized in broiler nutrition to alleviate the negative effects of the pathogenic microbes to promote performance. However, after the prohibition of antibiotics because of the increasing disclosure related to public health issues, various products have been developed as alternatives. This study was carried out to determine the effects of medium‐chain fatty acids (MCFAs) or phytobiotics (essential oils [EOs] and alkaloids [ALKs]), blended feed additives on the growth performance, jejunum histomorphology, and cecal microbiota of broiler chickens. A total of 765 male Ross 308 chicks were randomly distributed into 5 experimental groups, each having 9 replicates with 17 chicks. The experimental procedures were as follows: a control group without supplementation (T1); control group+ MCFAs and EOs blend (T2); control group+ different EOs blend (T3); control group+ ALK sanguinarine (T4); and control group+ EOs and ALK piperine mixture (T5). The results showed that, broilers fed with MCFAs blended with EOs had significantly greater body weight gain during overall period in comparision to the control and T3 groups. Further, only MCFAs blended with EOs group significantly improved jejnum morphology in comparison with the control group (p ≤ 0.05). Besides, the MCFAs blended with EOs group significantly elevated propionate, acetate and butyrate concentration, and decreased the concentration of branch chain fatty acids in caecum (p ≤ 0.05). The results indicated that, the combination of MCFAs and EOs seems to have improvement effects and could be preferred as an efficient feed additive in broiler production.
Detection of novel coronaviruses from dusky fruit bat (Penthetor lucasi) in Sarawak, Malaysian Borneo
Authors: Habeebur‐Rahman Sultana Parvin , Noni Vaenessa , Khan Faisal Ali Anwarali , Tan Cheng‐Siang 
Published: September 2023

AbstractBackgroundSarawak has one of the highest diversity of fruit bats species (family Pteropodidae) in Malaysia, with 19 species described. Most coronavirus (CoV) studies have mainly focused on insectivorous bats, resulting in a lack of information on CoVs present in frugivorous bats. In addition, bat CoV surveillance activities are lacking in Malaysia.ObjectivesOur study focuses on determining the presence of bat CoVs in dusky fruit bat (Penthetor lucasi).MethodsGuano samples belonging to P. lucasi were collected from Wind Cave Nature Reserve. The samples were screened for the presence of CoVs using validated hemi‐nested consensus RNA‐dependent RNA polymerase consensus primers.ResultsThe bat CoV positivity rate was 38.5% (n = 15/39), with the viruses belonging to two subgenera: Alphacoronavirus (α‐CoV) and Betacoronavirus (β‐CoV). Phylogenetic analysis revealed that CoVs from 14 samples of P. lucasi belong to the genus α‐CoV and may represent previously described genetic lineages in insectivorous bats in Wind Cave. However, only one sample of P. lucasi was detected with β‐CoV which is closely related to subgenus Nobecovirus, which is commonly seen in frugivorous bats.ConclusionsThis study provides the first available data on CoVs circulating in P. lucasi.
5‐Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog
Authors: Arbona Diana Victoria , Cowgill Larry D. , Press Saya , Dufayet Cedric , Istvan Stephanie 
Published: September 2023

AbstractObjectiveTo describe a case of 5‐hydroxytryptophan (5‐HTP) toxicity successfully treated with haemodialysis in a dog.Case SummaryA 3‐year‐old, male neutered Labrador Retriever, weighing 28.2 kg, presented to the emergency department approximately 4–5 h after ingesting a human supplement containing 200 mg of 5‐HTP. The amount of 5‐HTP ingested was estimated between 980 and 1988 mg (35–71 mg/kg). At presentation, the dog demonstrated progressive neurologic abnormalities consistent with serotonin syndrome, including altered mentation and ataxia. Due to the magnitude of the ingested dose and progression of clinical signs, extracorporeal blood purification with intermittent haemodialysis was chosen to expedite clearance of 5‐HTP. High‐efficiency haemodialysis was initiated, and the dog showed continued clinical improvement throughout the 5‐h treatment. Clinical signs resolved completely within 12 h. Sequential blood and urine samples were obtained to document levels of both 5‐HTP and serotonin. The dog was discharged 24 h after presentation with complete resolution of clinical signs.New or Unique InformationThis is the first report documenting the serial changes in 5‐HTP concentrations during treatment with haemodialysis.
Mycophenolate mofetil as a treatment for presumed idiopathic chronic hepatitis in dogs: Six cases (2010–2022)
Authors: Beehler Michelle K. , Kearns Shawn A. , Crouse Zachary J. 
Published: September 2023

AbstractObjectivesThe objectives of this study were to describe the clinical findings, treatment and outcomes of six dogs with presumed idiopathic chronic hepatitis treated with mycophenolate mofetil (MMF).Materials and MethodsMedical records were retrospectively searched to identify dogs in which idiopathic chronic hepatitis was diagnosed on histopathology between January 2010 and June 2022 that were treated with MMF for at least two weeks with >2 follow‐up examinations. Data recorded from each dog included signalment, clinical signs, diagnostic test results and treatment.ResultsSix dogs were treated with MMF at a median initial dosage of 9.6 mg/kg PO q 12 h. Reported adverse effects from MMF included decreased appetite, vomiting and diarrhoea.In all six dogs, MMF was used successfully long term for the treatment of idiopathic chronic hepatitis as determined by 46% or greater improvement of alanine aminotransferase (ALT) between 4 and 18 weeks of starting MMF. Three dogs were also temporarily treated for 4–6 months on a tapering dose of prednisone. In two dogs, ALT remained within the reference interval, and in one dog, it was very mildly elevated when on MMF alone. In all six dogs, owners reported that the medication was well tolerated.Clinical significanceTo the authors’ knowledge, this is the first report describing the use of MMF with and without a tapering dose of prednisone for the treatment of idiopathic chronic hepatitis in six dogs. Based on the outcomes of the dogs in this report, MMF can be effective for the long‐term treatment of idiopathic chronic hepatitis as measured by reduction in ALT and improvement of clinical signs.
Frequency stability analysis of a cantilever viscoelastic CNT conveying fluid on a viscoelastic Pasternak foundation and under axial load based on nonlocal elasticity theory
Authors: Mamandi Ahmad 
Published: September 2023

AbstractIn this paper, the frequency stability analysis of a fluid conveying cantilever viscoelastic carbon nanotube (CNT) in the Kelvin–Voigt material model with slip boundary condition (BC) regime on a viscoelastic Pasternak foundation and under axial load has been performed based on nonlocal Euler–Bernoulli thin beam theory. The governing partial differential equation of motion (EOM) and its associated BCs have been derived using the Hamilton principle. The governing EOM has been converted into an ordinary differential equation using mode summation technique and solved by applying the extended Galerkin method. Then, the frequency stability analysis has been carried out for the vibrational response of CNT in the state‐space form. The obtained results have been validated with the literature works. The effect of changes of various parameters like elastic stiffness, shear stiffness and damping coefficients of foundation, nonlocal scale‐effect parameter of the nanotube, fluid flow Knudsen number, mass ratio, structural damping of the nanotube and applied axial force have been investigated in terms of frequency to predict the occurrence of different instability modes for the system. It is concluded that flutter and divergence instabilities in the vibration of the viscoelastic CNT are significantly affected by changes of different above‐mentioned parameters.
Environmental, Social, and Economic Challenges in Lowland Rice Production
Authors: Connor Melanie , Malabayabas Arelene Julia B. , de Guia Annalyn H. , Wehmeyer Helena , Pame Anny Ruth P. , Htwe Nyo Me , Zhong Xuhua , Fu Youqiang , Liang Kaiming , Pan Junfeng , Hu Xiangyu , Liu Yanzhuo , Subekti Nuning Argo , Sembiring Hasil , Pustika Arlyna Budi , Sudarmaji  , Hutapea Yanter , Raharjo Budi , Girsang Setia Sari , Syahri  , Girsang Moral Abadi , Sumantri Renny Utami , Widyayanti Setyorini , Singleton Grant Robert , Tuan Le Anh 
Published: September 2023

AbstractThe CORIGAP project was implemented in six main rice granaries in South and Southeast Asia. The project introduced several country-specific sustainable best management practices, including nutrient management, pest management, water management, and several postharvest technologies, among other specific practices. This chapter introduces each country and its respective challenges to rice production. It outlines cultivation practices, historical developments, and their impacts on opportunities for the development of the rice sector. This is accompanied by specific case studies that highlight the adoption of specific technologies and practices. Case studies encompass the adoption of various best management practices in Myanmar and Thailand, especially postharvest technologies. Furthermore, the chapter highlights the outreach of “One Must Do, Five Reductions” in Vietnam, the development and implementation of the “Three Controls Technology” and alternate wetting and drying (AWD) practices in China, rodent pest management in Indonesia, and weed and water management in Sri Lanka. These case studies identified positive agronomic, social, and economic changes. The chapter concludes by harnessing the agricultural development strategies in each country with a synthesis of outcomes and impacts.
Innovations, Technologies, and Management Practices for Sustainable Rice Production
Authors: Nguyen-Van-Hung  , Gummert Martin , Flor Rica Joy , Ouk Akhara , Keo Makarakpakphea , Hadi Buyung , Tho Kim Eang , Then Rathmuny , Choun Saban , Hieu Pham Thi Minh , Sattler Cornelia , Connor Melanie , Sudarmaji  , Htwe Nyo Me , Sandro Joseph M. , Balingbing Carlito , Singleton Grant Robert 
Published: September 2023

AbstractOne of the major barriers to improving the rice value chain in Asian countries is farmers’ lack of knowledge and their limited access to good and scale-appropriate technologies and practices. This chapter reviews the main features, benefits, and potential barriers of technologies and practices developed and promoted under the CORIGAP project. These include One-Must-Do, Five-Reductions (1M5R); ecologically-based pest management; laser land leveling; mechanized crop establishment; and sustainable postharvest management practices. 1M5R (1M = certified Seed, 5R = reductions of seed rate, fertilizer, pesticides, water use, and postharvest losses) was introduced in Vietnam in 2004 and adopted on about 150,000 ha of rice production in the Mekong River Delta (MRD) of Vietnam. Ecologically based pest management is important for the sustainable production of rice. We provide an overview of CORIGAP research on eco-engineering for the management of insect pests and the continued development of ecologically-based rodent management. Laser land leveling and mechanized crop establishment help to significantly increase agronomic use efficiency. Applying LLL, combined with best management practices in rice production in Thailand (CROP), has improved farmers’ net income, increased nitrogen use efficiency, and reduced pesticide usage. Best postharvest management practices play an important role in upgrading the rice value chain tailored to sustainability. The chapter also includes lessons learned from case studies conducted in Southeast Asian countries, including Vietnam, Indonesia, Myanmar, and Thailand.
Partnerships and Approaches Used for Scaling: An Assessment of the Process for Rice Postharvest Technologies in CORIGAP
Authors: Flor Rica Joy , Quilloy Reianne , Maat Harro , Nguyen-Van-Hung  , Kyaw Myo Aung , Gummert Martin 
Published: September 2023

AbstractIn agriculture, many technologies are co-produced by research and a variety of other stakeholders, including farmers. Large-scale implementation of such technologies requires not only the distribution of the material components of a technology but also the replication of the social network, typically provided through facilitation of stakeholder involvement. Within the Consultative Group on International Agricultural Research (CGIAR), the now common procedure to enable stakeholder involvement is the creation of innovation platforms. The multi-stakeholder engagement initiated by these platforms enables the use of locally adapted technologies. This implies that the introduced technologies are not merely copied but require unpacking and repacking. In other words, a process of re-establishing the interconnectedness of the technology with varied socioeconomic arrangements and policies that enable its use. Understanding the process of scaling technologies thus requires analysis of the network that effectively catalyzes synergistic change and supports the adoption of technologies. However, the nature of the network, the types of partnerships, and the communication processes are situational and dynamic. It can take many years before newly introduced technologies become integrated into the routines of farming and accepted as a ‘normal’ technology. In this chapter, we provide a qualitative assessment of the partnerships and networks initiated by the Closing Rice Yield Gaps project (CORIGAP). Many of the CORIGAP partnerships were initiated during the predecessor project, the Irrigated Rice Research Consortium (IRRC). CORIGAP facilitated partnerships in different modalities, depending on the context of the countries and partners. This included partnerships with private-sector partners who, for example, provide services or inputs in return for subsidies or other financial arrangements. We reflect on the types of partnerships, how they are conceptualized, and how they created the needed connections and conditions to support the scaling of technologies introduced by CORIGAP. We also present cases of private-sector partnerships as examples of engagements with industries. We then dive into an approach that had been employed in several CORIGAP sites to facilitate the creation of a network for learning, innovation, and scaling of technologies. A case of using this approach in the Lower Ayeyarwady Delta of Myanmar is presented. We close the chapter with insights on the incentives these CORIGAP partnerships have enabled for scaling.
The compressible Navier–Stokes equations with slip boundary conditions of friction type
Authors: Nečasová Šárka , Ogorzaly Justyna , Scherz Jan 
Published: September 2023

AbstractWe study a mathematical model of a viscous compressible fluid obeying the slip boundary condition of friction type. We present a notion of weak solutions to this model, in which the momentum equation and the associated energy inequality are combined into a single relation. Moreover, the slip boundary condition of friction type is incorporated into this relation by the use of a boundary integral. Our main result proves the existence of such weak solutions. The proof of this result combines the classical existence theory for the compressible Navier–Stokes equations with an approximation of the aforementioned boundary integral via a convex regularization of the absolute value function.