bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Tick Abundance and Pyrethroid Resistance Via Determination of Glutathione-S-Transferases Activity
Authors: Vukčević Marija , Nikolić-Kokić Aleksandra , Aleksić Ivan , Todorović Sanja , Oreščanin-Dušić Zorana , Blagojević Duško , Despot Dragana 
Published: December 2022

Abstract
Controlling the number of ticks as carriers of infectious diseases is very important. The process is sometimes compromised by activating the protective mechanisms of the tick itself. Glutathione-S-transferases activity (GSTs) was the subject of our investigation of tick abundance after pyrethroid treatment. We determined GSTs activity in ticks collected from six locations in Belgrade before and after pyrethroid treatment and correlated it with the number of ticks in the locations. The results showed that tick abundance correlated with GSTs activity. On the other hand, treatment efficiency was location-dependent, being similar in each particular location in both April (spring) and October (autumn). Our results suggest that GSTs activity reflects the influence of both present local allelochemicals from different environmental seasonal vegetation and applied pyrethroid. We can conclude that by evaluating GSTs activity in ticks from particular locations as well as during the treatment with acaricides tick removal practice could be improved.
Commemorative Naming, Renaming, and the Role of Medical History in Academic Medicine
Authors: Manning Tequilla , Ingram Walter N , Crenner Christopher 
Published: December 2022

Abstract
The University of Kansas School of Medicine recently confronted challenging questions about commemorative naming. Every year, the school assigns the incoming medical students to advising groups, called academic societies. There are six societies, each bearing the name of a prominent physician from the school’s history. Over the years, as students learned about the society namesakes, controversy developed over the naming of the Wahl Society. In 1938, Dr. Harry Wahl led an effort to preserve the racial segregation of the medical school. He fought hard, though unsuccessfully, to defend the established practice of barring the few Black students admitted to the school from continuing into the third and fourth year of the program and graduating. In 2017, with this history in mind, a well-organized coalition of medical students submitted a request to change the name of the Wahl Society. The society is now named the Cates Society, honoring Dr. Marjorie Cates, the first Black woman to graduate from the medical school. In this paper, we offer observations on how medical students’ involvement with historical inquiry -- as well as their caution about it limits -- helped to navigate the challenging process of renaming.
How Communities Benefit from Collaborative Governance: Experimental Evidence in Ugandan Oil and Gas
Authors: Coleman Eric A , Schultz Bill , Parker A Rani , Manyindo Jacob , Mukuru Emmanuel M 
Published: December 2022

Abstract
This paper reports the results of a field experiment to assess the collaborative effects of community participation in the Ugandan oil and gas sector. Our research design assesses collaborative impacts as relational between community members and different decision-makers in the sector and measures these impacts from the point of view of local people. Local people often face power imbalances in collaborative governance. Decision-makers are increasingly attempting to mitigate such imbalances to improve outcomes for communities, but little experimental evidence exists showing the impact of such efforts. Using multilevel ordered logit models, we estimate positive treatment effects, finding that encouraging the equitable participation of communities improves collaboration with other actors. Next, we use machine-learning techniques to demonstrate a method for targeting communities most likely to benefit from the intervention. We estimate that purposefully targeting communities that would benefit most yields a treatment effect about twice as large, relative to pure random assignment. Our results provide evidence that interventions mindful of community needs can improve collaborative governance and shows how such communities can be most effectively targeted. The experiment took place across 107 villages (53 treatment and 54 control) and the unit of statistical analysis is the household, where we report outcomes measured from 6,062 household surveys (approximately half at baseline and half at endline).
Drivers of regulatory reform in Canadian health professions: Institutional isomorphism in a shifting social context
Authors: Adams Tracey L 
Published: December 2022

AbstractResearch has documented how the decline in professional self-regulation in the UK and Australia was led by policy-makers in response to regulatory failures. In Canada, professional self-regulation is currently in decline as well, and while policy-makers have driven some change it is also the case that self-regulating professions have begun to transform themselves from within: altering their structure, make-up, and processes to enhance fairness, public input, and accountability, while reducing professional control. Why would they do so? This paper draws on the concept of institutional isomorphism to understand why professional regulators would invoke changes that, on the surface, might seem to counteract their own interests. Analysing data from 46 interviews with leaders in healthcare profession regulation, this paper examines how coercive, mimetic, and normative processes drive regulatory reform in a changing regulatory field.
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats
Authors: Sahin Orhan , Akturk Gozde , Cilaker Micili Serap , Gursoy Doruk Ozlem , Karapinar Fazilet , Hocaoglu Nil , Ergur Bekir Ugur , Akan Pinar , Tuncok Yesim , Kalkan Sule 
Published: December 2022

Abstract

Objectives
The aim of this study is to evaluate the protective effect of nicorandil, a selective mitochondrial KATP channel opener, on QT prolongation and myocardial damage induced by amitriptyline.

Methods
The dose of amitriptyline (intraperitoneal, i.p.) that prolong the QT interval was found 75 mg/kg. Rats were randomized into five groups the control group, amitriptyline group, nicorandil (selective mitochondrial KATP channel opener, 3 mg/kg i.p.) + amitriptyline group, 5-hdyroxydecanoate (5-HD, selective mitochondrial KATP channel blocker, 10 mg/kg i.p.) + amitriptyline group and 5-HD + nicorandil + amitriptyline group. Cardiac parameters, biochemical and histomorphological/immunohistochemical examinations were evaluated. p &lt; 0.05 was accepted as statistically significant.

Key findings
Amitriptyline caused statistically significant prolongation of QRS duration, QT interval and QTc interval (p &lt; 0.05). It also caused changes in tissue oxidant (increase in malondialdehyde)/anti-oxidant (decrease in glutathione peroxidase) parameters (p &lt; 0.05), myocardial damage and apoptosis (p &lt; 0.01 and p &lt; 0.001). While nicorandil administration prevented amitriptyline-induced QRS, QT, QTc prolongation (p &lt; 0.05), myocardial damage and apoptosis (p &lt; 0.05), it did not affect the changes in oxidative parameters (p &gt; 0.05).

Conclusions
Our results suggest that nicorandil, a selective mitochondrial KATP channel opener, plays a protective role in amitriptyline-induced QT prolongation and myocardial damage. Mitochondrial KATP channel opening and anti-apoptotic effects may play a role in the cardioprotective effect of nicorandil.
The radiation response measurement of a single and multiple cell ionization of neuroblastoma cells by infrared laser trap
Authors: Goangul Mulugeta S , Stewart William C , Erenso Daniel , Crogman Horace T 
Published: December 2022

Abstract
Neuroblastoma (NB) is a common type of cancer found mostly in infants and arising from the immature neural crest cells of the sympathetic nervous system. Using laser trapping (LT) technique, the present work contributes to advancing radiotherapy (RT), a leading treatment method for cancer. A single, 2-cells, 3-cells, 4-cells, and 5-cells were trapped using the high-intensity gradient infrared laser at 1064 nm and allowed to become ionized. In this work, a systematic study of Threshold Ionization Energy (TIE) and Threshold Radiation Dose (TRD) versus mass for both single and multi-cell ionization using laser trapping (LT) techniques on NB is presented. The results show that TIE increased as the mass of cells increased, meanwhile TRD decreased with the increase of cell mass. We observed an inverse correlation between TRD and cell mass. We demonstrate how to compute the maximum radiation dosage for cell death using the LT technique. Results show a possible blueprint for computing the TRD in vivo. The use of multiple cell ionization to determine radiation dosage along with better data accuracy concerning the tumor size and density will have profound implications for radiation dosimetry. The diminution in TRD becomes more significant in multiple cell ionization as we see in TRD vs the number of cells entering the trap. This is due to the chain effect generated by radiation and the absorption by water molecules at 1064 nm. This result provides us with better insight into the optimization of the therapeutic ratio.
C-to-U and U-to-C: RNA editing in plant organelles and beyond
Authors: Knoop Volker 
Published: December 2022

AbstractThe genomes in the two energy-converting organelles of plant cells, chloroplasts and mitochondria, contain numerous ‘errors’ that are corrected at the level of RNA transcript copies. The genes encoded in the two endosymbiotic organelles would not function properly if their transcripts were not altered by site-specific cytidine-to-uridine (C-to-U) exchanges and by additional reverse U-to-C exchanges in hornworts, lycophytes, and ferns. These peculiar processes of plant RNA editing, re-establishing genetic information that could alternatively be present at the organelle genome level, has spurred much research over &gt;30 years. Lately new studies have revealed numerous interesting insights, notably on the biochemical machinery identifying specific pyrimidine nucleobases for conversion from C to U and vice versa. Here, I will summarize prominent research findings that lately have contributed to our better understanding of these phenomena introducing an added layer of information processing in plant cells. Some of this recent progress is based on the successful functional expression of plant RNA editing factors in bacteria and mammalian cells. These research approaches have recapitulated natural processes of horizontal gene transfer through which some protist lineages seem to have acquired plant RNA editing factors and adapted them functionally for their own purposes.
Sporothrix pathogenic clade: Molecular analysis of animal and human clinical isolates
Authors: Ribeiro-Marques Mariela Domiciano , Maschio-Lima Taiza , Lemes Thiago Henrique , Siqueira João Paulo Zen , Brizzotti-Mazuchi Natália Seron , Caetano Maicon Henrique , Almeida Bianca Gottardo , Mozaner Leticia Queiroz , Monteiro Ruan Campos , Camargo Zoilo Pires , Rodrigues Anderson Messias , Gottardo de Almeida Margarete Teresa 
Published: December 2022

Abstract
Sporotrichosis is a subcutaneous mycosis that affects animals and humans. Varying in severity, occurrences range from local lesions to systemic involvement. It is caused by thermodimorphic and saprobic fungi from the Sporothrix pathogenic clade. This study aimed to identify the species and the sexual idiomorph distribution patterns responsible for diagnosed cases of sporotrichosis in São José do Rio Preto, Brazil. We included 188 isolates of Sporothrix sp. from feline lesions and 27 of human origin, which underwent molecular identification and genotyping for mating-type MAT1-1 and MAT1-2. The results showed that Sporothrix brasiliensis is the prevalent species in feline sporotrichosis outbreaks with the overwhelming presence of a single mating-type, MAT1-2 (P &lt;.0001), suggesting a prevalently clonal form of spread. Morphological analyses did not discriminate among cryptic species in the genus Sporothrix, and molecular identification was essential for the correct identification of the species responsible for the observed cases of sporotrichosis. Distribution analyses of MAT1-2 isolates support the hypothesis of unidirectional migration from the current epidemics in São Paulo and Rio de Janeiro to the municipality of São José do Rio Preto.
New insights into the helium star formation channel of AM CVn systems with explanations of Gaia14aae and ZTFJ1637+49
Authors: Sarkar Arnab , Ge Hongwei , Tout Christopher A 
Published: December 2022

ABSTRACT
We model helium-rich stars with solar metallicity (X = 0.7, Z = 0.02) progenitors that evolve to form AM Canum Venaticorum systems through a helium-star formation channel, with the aim to explain the observed properties of Gaia14aae and ZTFJ1637+49. We show that semidegenerate, H-exhausted (X ≤ 10−5), He-rich (Y ≈ 0.98) donors can be formed after a common envelope evolution (CEE) phase if either additional sources of energy are used to eject the common envelope, or a different formalism of CEE is implemented. We follow the evolution of such binary systems after the CEE phase using the Cambridge stellar evolution code when they consist of a He-star and a white dwarf accretor, and report that the mass, radius, and mass-transfer rate of the donor, the orbital period of the system, and the lack of hydrogen in the spectrum of Gaia14aae and ZTFJ1637+49 match well with our modelled trajectories wherein, after the CEE phase Roche lobe overflow is governed not only by the angular momentum loss (AML) owing to gravitational wave radiation (AMLGR) but also an additional AML owing to α–Ω dynamos in the donor. This additional AML is modelled with our double-dynamo (DD) model of magnetic braking in the donor star. We explain that this additional AML is just a consequence of extending the DD model from canonical cataclysmic variable donors to evolved donors. We show that none of our modelled trajectories match with Gaia14aae or ZTFJ1637+49 if the systems are modelled only with AMLGR.
Evidence of underdeveloped torus and broad-line region of weak emission line quasars based on their spectral energy distribution
Authors: Kumar Ritish , Chand Hum , Joshi Ravi 
Published: December 2022

ABSTRACT
To unravel the dominant cause of the weak emission line in a subset of optically selected radio-quiet ‘weak emission line quasars’ (WLQs), we have investigated the possibility of an underdeveloped broad line region (BLR). For this, we have modelled spectral energy distributions (SED) of 61 WLQs by using their optical and infrared (IR) photometric observations from Sloan Digital Sky Survey (SDSS) and WISE, respectively. SED fit consists of various emission components, including the luminosity from the dusty torus (Ltor). For comparison with the normal quasar, we have used a control sample of 55 Quasi-Stellar Objects (QSOs) for each WLQ matching in emission redshift and SDSS r-band. Based on our measurement of Ltor, we found a decrement of 42 ± 2 per cent in IR luminosity in WLQs with respect to the control sample of normal QSOs. Using Ltor/Lbol as the measure of torus covering factor (CFtor), we found a similar decrement in WLQ covering factor, with their CFtor distribution being significantly different with respect to the normal QSOs with a KS test Pnull of 4.27 × 10−14. As dusty torus and BLR covering factors are expected to be of a similar order in active galactic nucleus (AGN), our results suggest that the BLR in the WLQs is underdeveloped and could be a dominant cause of the weakness of their emission line. As a result, our analysis gives support to the models of WLQs based on the evolution scenario being in an early stage of AGNs.
Impact of Mg ii interstellar medium absorption on near-ultraviolet exoplanet transit measurements
Authors: Sreejith A G , Fossati L , Cubillos P E , Ambily S , France K 
Published: December 2022

ABSTRACT
Ultraviolet (UV) transmission spectroscopy probes atmospheric escape, which has a significant impact on planetary atmospheric evolution. If unaccounted for, interstellar medium absorption (ISM) at the position of specific UV lines might bias transit depth measurements, and thus potentially affect the (non-)detection of features in transmission spectra. Ultimately, this is connected to the so called ‘resolution-linked bias’ effect. We present a parametric study quantifying the impact of unresolved or unconsidered ISM absorption in transit depth measurements at the position of the Mg ii h&k resonance lines (i.e. 2802.705 Å and 2795.528 Å, respectively) in the near-ultraviolet spectral range. We consider main-sequence stars of different spectral types and vary the shape and amount of chromospheric emission, ISM absorption, and planetary absorption, as well as their relative velocities. We also evaluate the role played by integration bin and spectral resolution. We present an open-source tool enabling one to quantify the impact of unresolved or unconsidered Mg ii ISM absorption in transit depth measurements. We further apply this tool to a few already or soon to be observed systems. On average, we find that ignoring ISM absorption leads to biases in the Mg ii transit depth measurements comparable to the uncertainties obtained from the observations published to date. However, considering the bias induced by ISM absorption might become necessary when analysing observations obtained with the next generation space telescopes with UV coverage (e.g. LUVOIR, HABEX), which will provide transmission spectra with significantly smaller uncertainties compared to what obtained with current facilities (e.g. HST).
chronostar – II. Kinematic age and substructure of the Scorpius–Centaurus OB2 association
Authors: Žerjal Maruša , Ireland Michael J , Crundall Timothy D , Krumholz Mark R , Rains Adam D 
Published: December 2022

ABSTRACT
The nearest region of massive star formation – the Scorpius–Centaurus OB2 association (Sco–Cen) – is a local laboratory ideally suited to the study of a wide range of astrophysical phenomena. Precision astrometry from the Gaia mission has expanded the census of this region by an order of magnitude. However, Sco–Cen’s vastness and complex substructure make kinematic analysis of its traditional three regions, Upper Scorpius, Upper Centaurus-Lupus, and Lower Centaurus-Crux, challenging. Here, we use chronostar, a Bayesian tool for kinematic age determination, to carry out a new kinematic decomposition of Sco–Cen using full six-dimensional kinematic data. Our model identifies eight kinematically distinct components consisting of 8185 stars distributed in dense and diffuse groups, each with an independently fit kinematic age; we verify that these kinematic estimates are consistent with isochronal ages for K dwarfs. Both Upper Centaurus-Lupus and Lower Centaurus-Crux are split into two parts. The kinematic age of the component that includes PDS 70, one of the most well-studied systems currently forming planets, is 15 ± 3 Myr.
The obscured nucleus and shocked environment of VV 114E revealed by JWST/MIRI spectroscopy
Authors: Donnan F R , García-Bernete I , Rigopoulou D , Pereira-Santaella M , Alonso-Herrero A , Roche P F , Hernán-Caballero A , Spoon H W W 
Published: December 2022

ABSTRACT
Compact Obscured Nuclei (CONs) potentially hide extreme supermassive black hole (SMBH) growth behind large column densities of gas/dust. We present a spectroscopic analysis of the heavily obscured nucleus and the surrounding environment of the eastern region of the nearby (z = 0.02007) interacting galaxy VV 114 with the JWST Mid-InfraRed Instrument (MIRI). We model the spectrum from 4.9 to 28 μm to extract polycyclic aromatic hydrocarbon (PAH) emission and the underlying obscured continuum. We find that the NE nucleus (A) is highly obscured where the low PAH equivalent width (EW) ratio, EW(12.7)/EW(11.3), reveals a dust enshrouded continuum source. This is confirmed by decomposing the continuum into nuclear and star-forming where the nuclear component is found to be typical of CONs. The 11.3/6.2 PAH flux ratio is consistent with originating in star-forming regions rather than typical AGN. The second nucleus (B) is much less obscured, with PAH flux ratios also typical of star-forming regions. We do not detect any high ionization lines such as [Ne v] or [Ne vi] which suggests that if an AGN is present it must be highly obscured. Additionally, we detect a shock front south of the secondary nucleus (B) in the [Fe ii] (5.34 μm) line and in warm molecular hydrogen. The 6.2 PAH emission does not spatially coincide with the low-J transitions of H2 but rather appears strong at the shock front which may suggest destruction of the ionized PAHs in the post-shock gas behind the shock front.
Refractory PR3-positive ANCA-associated vasculitis with eosinophilia requiring anti-IL-5 therapy: A case report
Authors: Anderson Elizabeth , Friedman Marcia A 
Published: December 2022

ABSTRACT
This report describes a highly unusual and refractory case of proteinase-3–positive antineutrophil cytoplasmic autoantibody–associated vasculitis, which was associated with marked eosinophilia and only achieved remission after interleukin-5 blockade was added to maximal induction therapy. The patient was a healthy 18-year-old woman who presented with scleritis, otitis, constitutional symptoms, skin and mucosal lesions, and diffuse alveolar haemorrhage and found to have refractory eosinophilia of unclear aetiology. The case did not meet classification criteria for a diagnosis of granulomatosis with polyangiitis or eosinophilic granulomatosis with polyangiitis. Despite induction therapy with glucocorticoids, cyclophosphamide, and rituximab, she did not achieve remission or normalisation of eosinophilia until the addition of mepolizumab, which corresponded to the suppression of peripheral blood eosinophils and clinical remission. This case highlights the limitations of classification criteria and success of interleukin-5 in a multimodal treatment of severe vasculitis with eosinophilia.