bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Holistic Framework for Factory Planning Using Reinforcement Learning
Authors: Klar M. , Mertes J. , Glatt M. , Ravani B. , Aurich J. C. 
Published: July 2023

AbstractThe generation of an optimized factory layout is a central element of the factory planning process. The generated factory layout predefines multiple characteristics of the future factory, such as the operational costs and proper resource allocations. However, manual layout planning is often time and resource-consuming and involves creative processes. In order to reduce the manual planning effort, automated, computer-aided planning approaches can support the factory planner to deal with this complexity by generating valuable solutions in the early phase of factory layout planning. Novel approaches have introduced Reinforcement Learning based planning schemes to generate optimized factory layouts. However, the existing research mainly focuses on the technical feasibility and does not highlight how a Reinforcement Learning based planning approach can be integrated into the factory planning process. Furthermore, it is unclear which information is required for its application. This paper addresses this research gap by presenting a holistic framework for Reinforcement Learning based factory layout planning that can be applied at the initial planning (greenfield planning) stages as well as in the restructuring (brownfield planning) of a factory layout. The framework consists of five steps: the initialization of the layout planning problem, the initialization of the algorithm, the execution of multiple training sets, the evaluation of the training results, and a final manual planning step for a selected layout variant. Each step consists of multiple sub-steps that are interlinked by an information flow. The framework describes the necessary and optional information for each sub-step and further provides guidance for future developments.
Häusliche Gewalt und ihre psychischen Folgen während der COVID-19-Pandemie – Zentrale Befunde aus dem deutschsprachigen Raum
Authors: Lotzin Annett , Flechsenhar Aleya , Garthus-Niegel Susan , Georg Anna Katharina , Holl Julia , von Hülsen Leonie , Kenntemich Laura , Kliem Sören , Kröger Christoph , Mack Judith T. , Mojahed Amera , Nunius Sabine , Schröder Johanna , Seitz Katja , von Thadden Alexandra , Volkert Jana , Zrnic Novakovic Irina , Lueger-Schuster Brigitte 
Published: July 2023

ZusammenfassungDie Auswirkungen traumatischer Erfahrungen auf die psychische Gesundheit während der COVID-19-Pandemie sind im deutschsprachigen Raum bisher unzureichend diskutiert worden. Vor diesem Hintergrund wurde im Auftrag der Deutschsprachigen Gesellschaft für Psychotraumatologie (DeGPT) eine Arbeitsgruppe aus wissenschaftlich und praktisch tätigen Fachkolleginnen und -kollegen gebildet. Ziel der Arbeitsgruppe war es, zentrale Forschungsbefunde zur Prävalenz von häuslicher Gewalt und damit einhergehende psychische Belastungen während der COVID-19-Pandemie im deutschsprachigen Raum zusammenzufassen und deren Implikationen zu diskutieren. Darüber hinaus sollten Zusammenhänge zwischen vorbestehenden Kindheitstraumata und psychischen Belastungen während der Pandemie beleuchtet werden. Hierzu wurde die vorliegende narrative Übersichtsarbeit erstellt.Die Ergebnisse der durchgeführten Studien weisen auf hohe Prävalenzen häuslicher Gewalt während der COVID-19-Pandemie hin, die jedoch überwiegend den Prävalenzen vor der Pandemie entsprechen. Erwachsene, die während der Pandemie oder bereits in ihrer Kindheit oder Jugend interpersonaler Gewalt ausgesetzt waren, wiesen während der Pandemie eine erhöhte psychische Belastung im Vergleich zu Erwachsenen ohne Gewalterfahrungen auf. Eine Reihe an Faktoren (z. B. weibliches Geschlecht, geringe Sozialkontakte) erhöhten das Risiko für psychische Belastung und Symptome einer posttraumatischen Belastungsstörung während der Pandemie. Nach diesen Ergebnissen stellen Menschen mit aktuellen, aber auch zurückliegenden Gewalterfahrungen eine vulnerable Gruppe dar, die während einer Pandemie besondere Unterstützungsbedarfe aufweist.
[18F]FDG PET/MRI combined with chest HRCT in early cancer detection: a retrospective study of 3020 asymptomatic subjects
Authors: Peng Liling , Liao Yi , Zhou Rui , Zhong Yan , Jiang Han , Wang Jing , Fu Yu , Xue Le , Zhang Xiaohui , Sun Mingxiang , Feng Gang , Meng Zhaoting , Peng Sisi , He Xuexin , Teng Gaojun , Gao Xin , Zhang Hong , Tian Mei 
Published: July 2023

Abstract
Purpose
PET/MRI has become an important medical imaging approach in clinical practice. In this study, we retrospectively investigated the detectability of fluorine-18 (18F)-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([18F]FDG PET/MRI) combined with chest computerized tomography (CT) for early cancer in a large cohort of asymptomatic subjects.

Methods
This study included a total of 3020 asymptomatic subjects who underwent whole-body [18F]FDG PET/MRI and chest HRCT examinations. All subjects received a 2–4-year follow-up for cancer development. Cancer detection rate, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the [18F]FDG PET/MRI with or without chest HRCT were calculated and analyzed.

Results
Sixty-one subjects were pathologically diagnosed with cancers, among which 59 were correctly detected by [18F]FDG PET/MRI combined with chest HRCT. Of the 59 patients (32 with lung cancer, 9 with breast cancer, 6 with thyroid cancer, 5 with colon cancer, 3 with renal cancer, 1 with prostate cancer, 1 with gastric cancer, 1 with endometrial cancer, and 1 with lymphoma), 54 (91.5%) were at stage 0 or stage I (according to the 8th edition of the tumor-node-metastasis [TNM] staging system), 33 (55.9%) were detected by PET/MRI alone (27 with non-lung cancers and 6 with lung cancer). Cancer detection rate, sensitivity, specificity, PPV, and NPV for PET/MRI combined with chest CT were 2.0%, 96.7%, 99.6%, 83.1%, and 99.9%, respectively. For PET/MRI alone, the metrics were 1.1%, 54.1%, 99.6%, 73.3%, and 99.1%, respectively, and for PET/MRI in non-lung cancers, the metrics were 0.9%, 93.1%, 99.6%, 69.2%, and 99.9%, respectively.

Conclusions
[18F]FDG PET/MRI holds great promise for the early detection of non-lung cancers, while it seems insufficient for detecting early-stage lung cancers. Chest HRCT can be complementary to whole-body PET/MRI for early cancer detection.

Trial registration
ChiCTR2200060041. Registered 16 May 2022. Public site: https://www.chictr.org.cn/index.html
Upper Eyelid Blepharoplasty: Surgical Techniques and Results—Systematic Review and Meta-analysis
Authors: Rodrigues Catarina , Carvalho Francisco , Marques Marisa 
Published: July 2023

Abstract
Background
Upper eyelid blepharoplasty is a surgical procedure that aims to correct the typical changes that occur with aging to the periorbital area. The outcomes of this surgery are aesthetic, as well as functional. Many studies have described an impact on the cornea, intraocular pressure, dry eye syndrome, and visual quality. The aim of this systematic review is to compare the different surgical techniques and their outcomes.

Methods
The authors performed a literature review through online databases PubMed, Web of Science, Clinicaltrials.gov, and CENTRAL libraries. Information was collected about the surgery techniques and the functional and aesthetic outcomes as well as complications of the interventions. Six types of upper blepharoplasty surgery were studied. Data were analyzed using Cochrane RevMan.

Results
Twenty studies were included in our systematic review and nine in our meta-analysis. We presented results about intraocular pressure, central corneal thickness, flattest keratometry, steepest keratometry, corneal astigmatism, visual acuity, Schirmer test 1 and 2, tear film break-up time and the ocular surface disease index questionnaire, according to type of surgery. Our meta-analysis showed no significant results.

Conclusions
No significant results were found; however, many studies reported an impact of upper blepharoplasty surgery in the outcomes studied. Only a small number of complications were reported, and patients were satisfied with the aesthetic outcomes.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266.
The Effect of Microwave and Radiofrequency Ablation (MWA/RFA) on Liver Volume in Patients with Primary and Secondary Liver Tumours: A Retrospective Analysis
Authors: Knapen Robrecht R. M. M. , Korenblik Remon , James Sinead , Dams Glenn , Olij Bram , de Boer Sanne W. , van Dam Ronald M. , van der Leij Christiaan 
Published: July 2023

Abstract
Purpose
It is known that thermal liver ablation can induce liver hypertrophy. However, exact impact in liver volume remains unclear. The aim of this study is to assess the influence of radiofrequency or microwave ablation (RFA/MWA) on liver volume in patients with primary and secondary liver lesions. Findings can be relevant in assessing the potential extra benefit of thermal liver ablation in preoperatively performed liver hypertrophy inducing procedures, such as portal vein embolization (PVE).

Methods
Between January 2014–May 2022, 69 invasive treatment naïve patients with primary (n = 43) or secondary/metastatic (n = 26) liver lesions (in all segments, except in segments II/III) treated percutaneously by RFA/MWA were included. Total liver volume (TLV), segment II + III volume (serving as “distant liver volume”), ablation zone volume and absolute liver volume (ALV, calculated by subtracting the ablation zone volume from the TLV) were the study outcomes.

Results
ALV in patients with secondary liver lesions increased to a median percentage of 106.87% (IQR = 99.66–113.03%, p = 0.016), volume of segments II/III increased to a median percentage of 105.81% (IQR = 100.06–115.65%, p = 0.003). ALV and segments II/III in patients with primary liver tumours remained stable, with a median percentage of 98.72% (IQR = 92.99–108.35%, p = 0.856) and 100.43% (IQR = 92.85–109.41%, p = 0.699), respectively.

Conclusion
In patients with secondary liver tumours, ALV and segments II/III increased after MWA/RFA by an average of approximately 6%, while ALV in patients with primary liver lesions remained unchanged. Besides the curative intent, these findings indicate the potential added benefit of thermal liver ablation on FLR hypertrophy inducing procedures in patients with secondary liver lesions.

Level of evidence
Level 3, non-controlled retrospective cohort study.

Graphical abstract
U–Pb and trace element zircon and apatite petrochronology of eclogites from the Scandinavian Caledonides
Authors: Jaranowski Maciej , Budzyń Bartosz , Barnes Christopher J. , Majka Jarosław , Sláma Jiří , Kozub-Budzyń Gabriela A. , Kośmińska Karolina 
Published: July 2023

AbstractThe petrochronological records of eclogites in the Scandinavian Caledonides are investigated using EPMA and LA-ICPMS of zircon and apatite for U–Pb geochronology, combined with major and trace element characteristics. Metamorphic zircon from two eclogites from the Lofoten-Vesterålen Complex (Lofoten Archipelago region) collectively yielded a Concordia age 427.8 ± 5.7 Ma and an upper intercept U–Pb age 425 ± 30 Ma. Apatites from the same eclogites provided U–Pb lower intercepts at 322 ± 28 Ma and 354 ± 33 Ma, with the latter also yielding a younger age of 227 ± 24 Ma. Two eclogites from the Lower Seve Nappe (Northern Jämtland) demonstrate different zircon and apatite age records. Metamorphic zircon provided Concordia ages of 467.2 ± 5.9 Ma and 444.5 ± 5.5 Ma, which resolve the age of prograde metamorphism and zircon growth during retrogression, respectively. The lower intercept U–Pb ages of apatites from the same eclogites are 436 ± 18 and 415 ± 25 Ma, respectively. In combination with their geochemical characteristics, they suggest two separate stages of exhumation of eclogite bodies in the Lower Seve Nappe. Zircons from an eclogite from the Blåhø Nappe (Nordøyane Archipelago) yielded a continuum of concordant U–Pb dates from ca. 435 to 395 Ma, which suggests several cycles of HT metamorphism within short intervals. Distinctive trace element characteristics of apatites from the Blåhø Nappe eclogite suggest formation coeval with zircon and garnet during HT metamorphism, but Pb diffusion behaved as an open system until cooling during exhumation of the nappe at 390 ± 12 Ma (lower intercept U–Pb age of apatite). To summarize, this study presents the high potential of coupled zircon and apatite petrochronology of eclogites in resolving their metamorphic evolution, particularly with respect to using trace element characteristics of apatites to constrain the records of their growth, alterations and the meaning of their U–Pb age record.
Lithium und Cobalt – Chancen und Probleme in Bezug auf zwei kritische Rohstoffe in der EU
Authors: Lughofer Clemens , Tost Michael 
Published: July 2023

ZusammenfassungUm die Abhängigkeit der Kobalt- und Lithiumversorgung der Europäischen Union von Nicht-EU Ländern zu minimieren, werden neue Möglichkeiten zur Selbstversorgung gesucht. Sowohl die primäre als auch die sekundäre Gewinnung dieser beiden Rohstoffe besitzt innerhalb der Europäischen Union großes Potenzial. Lagerstätten in Finnland (Kobalt) und Spanien (Lithium) dienen neben dem Recycling von Kobalt- und Lithiumhaltigen Lithium-Ionen-Batterien in Norwegen und Deutschland als Basis für eine geringere Abhängigkeit der EU. In diesem Artikel werden die oben genannten Potenziale sowie Substitutionsmöglichkeiten dieser beiden kritischen Rohstoffe näher beschrieben.
GLP-1RAs and cardiovascular disease: is the endothelium a relevant platform?
Authors: Menghini Rossella , Casagrande Viviana , Rizza Stefano , Federici Massimo 
Published: July 2023

AbstractHyperglycemia strongly affects endothelial function and activation, which in turn increases the risk of atherosclerotic cardiovascular disease. Among pharmacotherapies aimed at lowering blood glucose levels, glucagon-like peptide 1 receptor agonists (GLP-1RA) represent a class of drugs involved in the improvement of the endothelium damage and the progression of cardiovascular diseases. They show antihypertensive and antiatherosclerotic actions due at least in part to direct favorable actions on the coronary vascular endothelium, such as oxidative stress reduction and nitric oxide increase. However, cumulative peripheral indirect actions could also contribute to the antiatherosclerotic functions of GLP-1/GLP-1R agonists, including metabolism and gut microbiome regulation. Therefore, further research is necessary to clarify the specific role of this drug class in the management of cardiovascular disease and to identify specific cellular targets involved in the protective signal transduction. In the present review, we provide an overview of the effects of GLP-1RAs treatment on cardiovascular disease with particular attention on potential molecular mechanisms involving endothelium function on formation and progression of atherosclerotic plaque.
Sentinel lymph node identification using contrast-enhanced ultrasound in breast cancer: review of the literature
Authors: Omoto Kiyoka , Futsuhara Kazushige , Watanabe Tamami 
Published: July 2023

Abstract
Before breast cancer surgery, sentinel lymph node (SLN) identification and biopsy using blue dye, radioisotope (RI) with a gamma probe, or a combination of the two are mainly performed. The dye-guided method requires skilled technique to make an incision in the skin and identify SLNs without damaging the lymphatic vessels. In addition, dye-induced anaphylactic shock has been reported. To use the γ-probe-guided method, the facility must be able to handle RI. However, to overcome the drawbacks of these methods, Omoto et al. developed a new identification modality using contrast-enhanced ultrasound with an ultrasound contrast agent (UCA) in 2002. Since then, many basic experiments and clinical studies using various UCA have been reported. In particular, a number of studies in SLN detection using Sonazoid have been reported and are herein reviewed.
Reputation compensation for incentive alignment in a supply chain with trade credit under information asymmetry
Authors: Wang Zhihong , Zhao Lima , Shao Yuwei , Wen Xiaojuan 
Published: July 2023

AbstractThis paper examines a two-period dynamic contracting in a supply chain under information asymmetry, where a supplier sells a product to a retailer via a trade credit contract. It is found that the retailer always prefers to conceal her actual cost information thus signal as a higher-cost type in the first period to pursue a higher information rent, which would decrease the supplier’s profit and thereby the overall profit of the supply chain. To mitigate this ratchet effect, we introduce a reputation compensation mechanism in the two-period trade credit setting. This mechanism could alleviate the information asymmetry to a certain extent as there exists a threshold that incentivizes the retailer to share her true cost information in the earlier period. Moreover, the retailer might claim as a lower-cost type when the supplier offers a relatively higher reputation compensation to take full advantage of her information. Therefore, the supplier should provide trade credit with a reasonable reputation compensation in a two-period setting to enhance his expected profit.
TIMESS a power analysis tool to estimate the number of locations and repeated measurements for seasonally and clustered mosquito surveys
Authors: Sedda Luigi , Taylor Benjamin M. , Cain Russell , Vajda Élodie A. , Tatarsky Allison , Lobo Neil F. 
Published: July 2023

AbstractEvery day, hundreds of mosquito surveys are carried out around the world to inform policy and management decisions on how best to reduce or prevent the burden of mosquito-borne disease or mosquito nuisance. These surveys are usually time consuming and expensive. Mosquito surveillance is the essential component of vector management and control. However, surveillance is often carried out with a limited if not without a quantitative assessment of the sampling effort which can results in underpowered or overpowered studies, or certainly in overpowered studies when power analyses are carried out assuming independence in the measurements obtained from longitudinal and geographically proximal mosquito surveys. Many free, open-source and user-friendly tools to calculate statistical power are available, such as G*Power, glimmpse, powerandsamplesize.com website or R-cran packages (pwr and WebPower to name few of them). However, these tools may not be sufficient for powering mosquito surveys due to the additional properties of seasonal and spatially clustered repeated measurements required to reflect mosquito population dynamics. To facilitate power analysis for mosquito surveillance, we have developed TIMESS, a deployable browser-based Shiny app that estimates the number of repeated measurements and locations of mosquito surveys for a given effect size, power, significance level, seasonality and level of expected between-location clustering. In this article we describe TIMESS, its usage, strengths and limitations.
Learning rewards from exploratory demonstrations using probabilistic temporal ranking
Authors: Burke Michael , Lu Katie , Angelov Daniel , Straižys Artūras , Innes Craig , Subr Kartic , Ramamoorthy Subramanian 
Published: July 2023

AbstractInformative path-planning is a well established approach to visual-servoing and active viewpoint selection in robotics, but typically assumes that a suitable cost function or goal state is known. This work considers the inverse problem, where the goal of the task is unknown, and a reward function needs to be inferred from exploratory example demonstrations provided by a demonstrator, for use in a downstream informative path-planning policy. Unfortunately, many existing reward inference strategies are unsuited to this class of problems, due to the exploratory nature of the demonstrations. In this paper, we propose an alternative approach to cope with the class of problems where these sub-optimal, exploratory demonstrations occur. We hypothesise that, in tasks which require discovery, successive states of any demonstration are progressively more likely to be associated with a higher reward, and use this hypothesis to generate time-based binary comparison outcomes and infer reward functions that support these ranks, under a probabilistic generative model. We formalise this probabilistic temporal ranking approach and show that it improves upon existing approaches to perform reward inference for autonomous ultrasound scanning, a novel application of learning from demonstration in medical imaging while also being of value across a broad range of goal-oriented learning from demonstration tasks.
Influence of microbial biomass content on biodegradation and mechanical properties of poly(3-hydroxybutyrate) composites
Authors: Eckel Felix , Sinzinger Korbinian , Van Opdenbosch Daniel , Schieder Doris , Sieber Volker , Zollfrank Cordt 
Published: July 2023

AbstractBiodegradation rates and mechanical properties of poly(3-hydroxybutyrate) (PHB) composites with green algae and cyanobacteria were investigated for the first time. To the authors knowledge, the addition of microbial biomass led to the biggest observed effect on biodegradation so far. The composites with microbial biomass showed an acceleration of the biodegradation rate and a higher cumulative biodegradation within 132 days compared to PHB or the biomass alone. In order to determine the causes for the faster biodegradation, the molecular weight, the crystallinity, the water uptake, the microbial biomass composition and scanning electron microscope images were assessed. The molecular weight of the PHB in the composites was lower than that of pure PHB while the crystallinity and microbial biomass composition were the same for all samples. A direct correlation of water uptake and crystallinity with biodegradation rate could not be observed. While the degradation of molecular weight of PHB during sample preparation contributed to the improvement of biodegradation, the main reason was attributed to biostimulation by the added biomass. The resulting enhancement of the biodegradation rate appears to be unique in the field of polymer biodegradation. The tensile strength was lowered, elongation at break remained constant and Young’s modulus was increased compared to pure PHB.