bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature-based solutions for flood–drought mitigation using a composite framework: a case-based approach
Authors: Agarwal Divya S. , Bharat Alka 
Published: February 2023

AbstractWater-related hazards like floods and droughts are increasing due to climate change. The study aims towards balancing a double edge situation of the inevitable flood and drought. The Soil Conservation Service-Curve Number (SCS-CN) method is used to calculate the rainfall–runoff and the Topographic Wetness Index (TWI) is used for identifying potential water accumulation zones, whereas the Normalized Differential Water Index (NDWI) is used to calculate surface waterbody variations and the Soil Water Index (SWI) is used to identify zones varying in the range of dry-to-wet soil moisture. The study focuses on the use of nature-based solutions (NbS) for achieving mutual flood–drought mitigation for the pilot case of the Banaskantha district, Gujarat, and is validated for the study case of the Muzaffarpur district, Bihar. The application of the developed contingency plan in the form of an applicability rubric agrees to solve the issue by 44.44% for the pilot case and 22.22% for the study case. It suggests the application of NbS for the regions having similar situations of flood–drought as of the pilot case.
Expression and Predictive Significance of FHL1 and SLIT3 in Surgically
Resected Lung Adenocarcinoma
Authors: Song Jinjing , Liang Kai , Wei Tongtong , Li Li , Huang Zhiguang , Chen Gang , Mao Naiquan , Yang Jie 
Published: February 2023

Objective:
Lung adenocarcinoma (LUAD) is the most common type of lung cancer.
However, predictive biomarkers for early efficacy and prognosis evaluation in patients with surgically
resected LUAD are not completely explained.

Methods:
Differentially expressed genes (DEGs), gene ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) were identified by RNA sequencing (RNA-Seq) between thirteen
LUAD tissues and five normal lung tissues. The expression of DEGs was confirmed by qRT-PCR
and a validated cohort from GEPIA. Protein-protein interaction (PPI) network of the top 5% DEGs
was constructed by STRING and visualized in Cytoscape. Immunofluorescence results were acquired
from clinical specimens from LUAD patients. The expression of FHL1 was analyzed by
ImageJ. Survival analysis was performed using the GEPIA dataset.

Results:
Consistent with the RNA-Seq data, validation of DEGs expression by qRT-PCR and GEPIA
cohort showed that FHL1 and SLIT3 were down-regulated in LUAD patient tissues compared
with non-tumor tissues. Moreover, FHL1 was significantly reduced in LUAD cell lines compared
to the bronchial epithelium cell line (P <0.01). However, SLIT3 was elevated in A549 and H1299
cells (wide type EGFR) (P < 0.05) while decreased in HCC827 and PC9 cells (mutant EGFR)
compared to BESA-2B cells (P < 0.01). PPI network revealed the most significant cluster with 10
nodes and 43 edges. Immunofluorescent staining also showed that the expression of FHL1 was
lower in LUAD tissues compared with that in normal lung tissues (P < 0.01). The expressions of
SLIT3 and FHL1 were positively correlated. Specifically, the higher expression level of SLIT3 and
FHL1 independently predicted a better prognosis (P < 0.01 or P < 0.05).

Conclusion:
Our findings provide two novel candidates, FHL1 and SLIT3, for prognostic evaluation
and treatments after surgery.
A randomised comparative clinical study to assess the efficacy of Arjuna Twak Churna Lepa and Yastimadhu Churna Lepa along with Khadira Churna in the management of Vyanga with special reference to Melasma
Authors: Kamala Hunasagi  , Uma Patil  
Published: February 2023

Background: Vyanga is one of the skin disease and it is included under the heading of a Kshudra Rogas. Vyanga is pathological condition of the facial skin which is produced by the vitiation of the Vata, Pitta Doshas and Rakta Dhatu and Manasika Nidanas such as Bhaya, Krodha and Shoka are the main culprits characterized by the presence of Niruja, Tanu, and Shyava Mandalas over the face. Vyanga is correlated with facial Melasma, melasma is skin condition in which a hyperpigmented patches over the face of the individual showing the similarities in clinical features. Objectives: To assess the efficacy of Arjuna Twak Churna Lepa and Yastimadhu Churna Lepa along with Khadira Churna in the management of Vyanga with special reference to melasma. Methodology: A comparative clinical study was conducted on Vyanga Roga for the period of 21 days. The patients were divided into 2 groups. In Group A 20 patients were administered with Arjuna Twak Churna Lepa along with Khadira Sara Churna and in Group B 20 patients were administered with Yasthimadhu Churna Lepa along with Khadira Sara Churna. Results: Group A and Group B have shown statistically significant result. Group A treated with Arjuna Twak Churna Lepa along with Khadira Sara Churna shown better result compared with Group B treated with Yasthimadhu Churna Lepa along with Khadira Sara Churna.
A randomized controlled comparative clinical trial on Jwarahara effect of Mukkaamukkatukaadi Syrup with Kiratatikta Syrup in Febrile Children
Authors: Suja K  , Prathviraj Puranik  , Sharashchandra R  , Sandesh Kumar Shetty  
Published: February 2023

Ayurvedic classics have described many diseases amongst which Jwara stands first because of its uniqueness to make everyone suffer, since birth to death. Jwara being one of the commonest symptoms which accompanies almost all constitutional diseases has been coined with the term Rogadhipathi. Fever is defined as temperature in rectum more than 100.4°F (38°C), in oral cavity above 99.5°F (37.5°C) or in axilla above 99°F (37. 2°C). If we don’t treat fever in its earlier stage, there will be more chances of hyperpyrexia which may cause febrile convulsions which leads to brain damage. Therefore, it is necessary to control fever at its earlier stage. One such Jwarahara formulation is Mukkaamukkatukaadi Gulika and Kiratatikta which is converted into syrup form to overcome the palatability issues. A sample size of 30 patients was selected by simple random sampling method and 15 patients were allotted in two groups. It was planned to compare the result between Mukkaamukkatukaadi syrup in Group A study group for STG and LTG and Kiratatikta syrup in Group B control group for STG and LTG. On STG comparison, the difference in mean in Group A and Group B were 0.49,0.44 before treatment changed to 0.96 and 0.98 after treatment respectively. On LTG comparison, the difference in mean in Group A and Group B were 0.49, 0.44 before treatment changed to 2.02 and 1.96 after follow up respectively. This depicts both the formulations effective when consumed for longer duration. From the results and observations it can be concluded that Group A and Group B are equally effective and equally significant on reducing the temperature in both STG and LTG. No adverse drug reaction was found during the study.
A randomized comparative clinical study of Manjistha Ghrita (Rubia Cordifolia Linn.) and Go-Ghrita in the management of Kikkisa (Striae Gravidarum)
Authors: Spoorthi G Hegde  , Jalindar Dhamale  
Published: February 2023

Skin ailments are the third most common disease in developing countries and in modern society it is a subject of sociomedical importance. One such ailment associated with pregnancy is Kikkisa (Striae gravidarum). Kikkisa (Striae gravidarum) is a Garbhini Vyadhi which occurs mostly in Sapta Masa of Garbhini Kala (7th month of pregnancy). It is a condition where growing foetus enlarges Garbhashaya which displaces Doshas Vata, Pitta and Kapha upwards, reaches Uras and produces Daha causing Kandu on abdomen, breasts and thighs. Striae gravidarum are seen in 50-90% of pregnant women due to many physiological, metabolic and hormonal changes along with increased stress on connective tissue will lead to breakage of fibers. Manjistha (Rubia cordifolia Linn.) is considered as Raktashodaka and Kushtanuta. Considering the risk factors in pregnancy the current study has been taken up under external application of Manjistha in the form of Ghrita over internal usage of Kwatha as mentioned in authentic text. Keeping this in mind a comparative study was conducted to analyze the effect of Manjistha Ghrita and Go-Ghrita on Striae gravidarum.30 subjects after considering the inclusion and exclusion criteria were taken up for the study. Patient’s general and physical examinations were done. On day 0, through inspection if Striae were observed then Manjistha Ghrita and Go-Ghrita were given in alternative manner. Patients were asked to come for follow up on Day 15. The study period was 30 days and on Day 30, patients were examined to check for any changes in Striae. The obtained data were analyzed statistically using Paired T test, UnPaired T test, Wilcoxon test, Mann Witney test, by using SPSS Software. Usage of Manjistha Ghrita gave considerably good results statistically when compared to application of Go-Ghrita as it only helped in reducing the symptoms till the subjects used the medication and there was recurrence of symptoms later.
El debate sobre la laboralidad del trabajo vía plataformas digitales en Chile y algunos problemas conexos
Authors: Palomo Vélez Rodrigo , Contreras Vásquez Pablo , Jofré Bustos María Soledad , Sierra Herrero Alfredo 
Published: February 2023

El presente artículo pretende evaluar, respecto del caso chileno, los problemas jurídicos que plantea el trabajo vía plataformas digitales en la definición de los criterios identitarios de la relación laboral y de las tutelas jurídicas requeridas. No se vislumbra una categoría jurídica dotada de mejores atributos que la subordinación para delimitar el ámbito de aplicación de las normas laborales. Lo que ha de redefinirse son sus técnicas, sus características específicas, con vocación de adaptabilidad a las nuevas realidades del trabajo, como el que se presta mediante plataformas digitales. En efecto, es posible encontrar diversos patrones comunes que apuntan hacia la laboralidad, a través de una reinterpretación de la noción funcional de subordinación: los incentivos para mantener porcentajes altos de aceptación de servicios, el control a través de GPS, la existencia de algoritmos y otras herramientas digitales de control de desempeño, entre otros.
Asimismo, es necesario formular nuevas categorías jurídicas que permitan, por un lado, proyectar tutelas jurídicas específicas viables respecto de nuestro sistema normativo, particularmente frágil en protección laboral y social y, por otro, otorgar certeza jurídica a estas nuevas formas de trabajo, haciendo las distinciones que procedan.
Se trata de una investigación de tipo explicativo, que asumió el pluralismo metodológico como fórmula para someter a validación la hipótesis presentada, lo cual se concretó eminentemente tanto en la discusión bibliográfica como en la exégesis normativa y en el análisis de jurisprudencia.
Local Government Authority Over The Licensing and Supervision Of Pertamina Shop's Business
Authors: Yuhana Ersa , Noviades Dhil’s , Repindowaty Harahap Rahayu 
Published: February 2023

Abstract

The purpose of this research is to determine the Authority of local governments to implement Pertamina Shop Business Licensing and Supervision which is motivated by the Government's desire to realize equitable distribution of Fuel Oil to all regions in Indonesia. The issue raised was related to the role of the Regional Government in implementing the Pertashop program aimed at the scope of the Regency or Village. Provisions related to the implementation of Pertashop still do not provide clear limits of authority by the Central Government and Regional Governments. The results of this study show that the authority over the licensing of the Pertashop program remains the authority of the central government, but still has the involvement of the Regional Government and other bodies in accordance with the provisions of laws and regulations and the concept of regional autonomy. Furthermore, regulations related to pertashop business licensing requirements are further regulated in the regulation...of the Downstream Oil and Gas Regulatory Agency Number 6 of 2015 concerning the Distribution of Certain Types of Fuel Oil and Special Types of Fuel Assignments in Areas Where There are No Distributors.
Hipnose como método terapêutico na prática odontológica
Authors: DE SOUZA GOMES RAUL , FARIAS MACHADO EMANUELLE , MARQUES COLOMBO BEATRIZ , DE ALMEIDA DULTRA JOAQUIM , KAROLINE ARAÚJO ALVES DULTRA FÁTIMA 
Published: February 2023

Resumo

Este estudo trata-se de uma revisão de literatura e tem como objetivo principal destacar os efeitos terapêuticos proporcionados pela terapia hipnótica na prática odontológica. A pesquisa foi realizada nas bases de dados SciELO, PUBMED e BVS, considerando publicações no intervalo de 2011 a 2021, para isso, utilizou-se os seguintes descritores: hipnose, ansiedade, dor orofacial e odontologia. Os resultados do estudo apontam que a terapia hipnótica é eficaz para a analgesia, bem como para o controle do medo, ansiedade e estresse frente ao tratamento odontológico. Porém, apesar de ser uma técnica eficaz, ainda é pouco conhecida e/ou aceita tanto pelos profissionais da área quanto pelos pacientes.
Adaptational Mechanisms of Epiphytic Orchids: A Review
Authors:   ICAR-NRC for Orchids, Pakyong, Sikkim (737 106), India, De L. C. , Biswas S. S. ,   ICAR-NRC for Orchids, Pakyong, Sikkim (737 106), India
Published: February 2023

Orchidaceae belongs to the 84 families of vascular plants that cover species following the epiphytic life pattern. Adaptations are specialized mechanisms that permit a plant or animal to live in a particular area or habitat. Adaptational mechanisms in plant morphology are essential for the transition to an epiphytic canopy habitat. Orchids have specific adaptational mechanisms in the roots, stems, leaves, flowers, seed and other physiological processes. Under water scarcity, these orchids have developed pseudobulbs, an energy, water, and nutrient storage bulb for adaptations.A wax coating covering the surface of the leaf, also prevents evaporation and gas exchange in drier or hotter climate.Epiphytic orchids have adequate root systems to enable them to grow in a poor nutrient environment when they grow at slow rate. In such cases, velamen of orchids helps to absorb water and also help to absorb nutrients from rainfall. Orchid roots are adapted to cling to trees. Orchid seeds do not have endosperm and require a fungal association with mycorrhiza to provide its energy till the development of roots and leaves. This symbiotic feature is another adaption to make the orchid seed to travel longer and further distances for survival. In comparison to the activity of C3 photosynthesis, crassulacean acid metabolism (CAM) in many epiphytes plays a vital role in improving carbon gains and water use. In this review, specialized adaptations of some commercial orchid genera namely Dendrobium, Cymbidium, Phalaenopsis, Cattleya, Oncidium, Epidendrum and Paphiopedilum are discussed in detail.
Potential Immunological Biomarker for Diagnosis and Prognosis of Tuberculosis
Authors: A. Hussain Yassameen , Mohammed Khairallah A. S. , Ali Naael H. 
Published: February 2023

Tuberculosis (TB) is one of the most common infectious diseases in the world, which has led to numerous deaths. Hence, developing an efficient diagnostic method is essential to monitor and control such deadly infectious diseases. In the current study, the serum levels of four inflammatory markers (CXCL10, CXCL9, suPAR, and MMP9) and the expression NF-κB gene were evaluated as potential immunological markers for diagnosis and prognosis of tuberculosis, using ELISA and qPCR technique respectively. Thirty new TB patients and equal numbers of under treatment TB patients and control (healthy people) were conscripted in this study. The results showed significant differences in the serum level of CXCL10 among the three groups (p value 0.003) and between new and under treatment patients (P value 0.004). A significant difference in the CXCL9 level in the serum was observed between the new TB patients and the healthy group with p value 0.028 but didn’t reach the significant level between the new and under treatment patients. The serum level of suPAR was higher in new patients (106.59pg/ml) followed by treated patients (89.66pg/ml) and lowest in healthy group (80.71pg/ml) but didn’t reach the significant level. Also, the serum level of MMP-9 did not show a significant difference between the tested groups, but it was slightly higher in new patients (21.45ng/ml) compared to the healthy group (20.70ng/ml). The amount of NF-κB gene expression was significantly higher in new patients (8.21-fold change) than in under treatment patients (2.95-fold change) in comparing with healthy people.
Substituting Natural Honey for Cane Sugar (Sucrose) Retards Microbial Growth Independent of Water Activity During Storage of Tomato Jam
Authors: Kapira Kelvin , Nkhata Smith G. , Makolija Noel , Ayua Emmanuel O. , Aduol Kevin O. 
Published: February 2023

Today, there are several attempts to make nutritious food products low in glycemic carbohydrates as this can partly help in solving the ever-growing numbers of type 2 diabetes and obesity. We thus made two types of jam, one using conventional sucrose with a high glycemic index and the other using honey which is regarded as a low glycemic index carbohydrate. Honey jam had comparable physical properties with sucrose jam. The total soluble solid (Brix) was significantly lower in honey jam than in sucrose jam (p=0.04) indicating less sugar in honey jam. Both jams had comparatively higher percent moisture content than other jams reported in literature potentially suggesting reduced storage stability. Despite having higher water activity, honey jam had progressive decrease in microbial colony counts suggesting honey was inhibitory to growth of microorganism compared to sucrose jam. This effect was independent of water activity as sucrose jam which had lower water activity promoted growth of microorganism during storage. Therefore, substituting natural honey for sucrose during formulation of tomato jam retards microbial growth thereby prolonging shelf life.
KONSEP KELUARGA SAKĪNAH DALAM ALQURAN
Authors: Zaelani Abdul Qodir , Issusanto Issusanto , Hanif Abdul 
Published: February 2023

Membentuk keluarga bahagia (sakīnah) tidak semudah membalikkan telapak tangan. Banyak rintangan menghadang, dan dinamika yang mengguncang. Diperlukan pemahaman yang dalam untuk bisa menjalankannya sehingga cita-cita menjadi keluarga bahagia dapat terwujud. Berdasarkan pendekatan normatif, ditemukan konsep keluarga sakīnah dalam Alquran. Setelah ditelusuri, dalam Alquran secara implisit dijelaskan hakikat, visi dan fungsi berkeluarga. Terkonsep dalam Alquran, agar terbentuk keluarga sakīnah, diperlukan etika yang baik oleh anak kepada orang tua, menerapkan prinsip saling menerima, menghargai, mempercayai dan melengkapi, membudayakan berbuat kebaikan, saling memposisikan diri masing-masing, mendidik keluarga (intelektual, kepribadian dan sosial, akidah dan akhlak), serta menjalin hubungan akrab: menjalin ikatan cinta antara anak dan orang tua (ouderlikemacht).
IMPLEMENTASI ALGORITMA OTSU THRESHOLDING DENGAN MEDIAN FILTER DALAM SEGMENTASI CITRA DIGITAL NASKAH KUNO BATAK (STUDI KASUS: MUSEUM NEGERI PROVINSI SUMATERA UTARA)
Authors: Novita Nia 
Published: February 2023

ABSTRAKSebagian dari naskah kuno Batak yang ada di Museum Negeri Provinsi Sumatera Utara mengalami kerusakan seperti robek, tulisan tidak terlihat jelas sehingga susah untuk dibaca dan terdapat noda di naskah tersebut karena usianya yang sudah puluhan bahkan ratusan tahun. Naskah kuno Batak tidak akan bertahan lama jika tidak ditangani atau dirawat dengan baik. Oleh sebab itu dibutuhkanya sebuah perawat yang dapat melestarikan naskah kuno Batak dengan jangka yang lebih lama. Salah satu cara untuk melestarikan naskah kuno Batak dan membuat naskah kuno Batak lebih dapat dibaca serta jelas, maka dapat dilakukan dengan cara segmentasi citra. Dengan segmentasi citra, naskah kuno Batak dapat diubah kedalam bentuk naskah kuno Batak citra digital yang dapat disimpan kedalam media penyimpanan. Segmentasi citra yang diterapkan adalah melakukan pemisahan background citra naskah kuno dengan teks naskah kuno Batak kedalam bentuk citra hitam dan puith, sehingga citra naskah kuno Batak yang tidak jelas dapat dibaca lebih baik. Segmentasi citra memerlukan metode, pada penelitian ini metode yang digunakan adalah Otsu Thresholding dengan Median Filter, tahapan metode Otsu Thresholding adalah mengubah citra naskah kuno kedalam citra luminosity grayscale, kemudian mengitung nilai rata-rata dan threshold, sehingga dilakukan pemisahan berdasarkan nilai threshold kemudian dilanjutkan dengan tahapan Median Filter sehingga menghasilkan citra naskah kuno Batak dengan pemisahan antara objek dan background citra. Kata Kunci: Naskah Kuno, Batak, Segmentasi, Citra, Otsu Thresholding, Median
Insulin receptor substrate-1 gene polymorphism and lipid panel data in type 2 diabetic patients with comorbid obesity and/or essential hypertension
Authors: Marushchak Mariya , Mazur Lyudmyla , Krynytska Inna 
Published: February 2023

Abstract

Objective. The hallmarks of type 2 diabetes mellitus (T2DM) are insulin resistance (IR) and insulin receptor substrate (IRS) proteins essential for the insulin signaling. IRS-1 gene has not only been shown to be associated with T2DM, but also has indicated that it may significantly correlate with diabetic complications, such as coronary heart disease and obesity. The aim of this study was to evaluate changes of the lipid panel data in T2DM patients with comorbid obesity and/or essential hypertension in connection with the IRS-1 (rs2943640) polymorphism.

Methods. The study involved 33 T2DM patients and 10 healthy individuals. The IRS-1 (rs2943640) polymorphism was genotyped using a TaqMan real-time polymerase chain reaction method. Blood serum lipid panel data were determined with commercially available kits using a Cobas 6000 analyzer.

Results. Analysis of the serum lipid panel data depending on the presence of the C/A alleles of IRS-1 (rs2943640) polymorphism in T2DM patients, regardless of the presence/absence of comorbidities, showed significantly lower level of high-density lipoprotein cholesterol (HDL-C) and significantly higher level of non-HDL-C in the carriers of C allele vs. carriers of A allele. In T2DM patients with comorbid obesity and essential hypertension, proatherogenic lipid changes were found in both C and A alleles carriers. Analysis of the effect of IRS-1 (rs2943640) genotypes on serum lipid panel data in T2DM patients, regardless of the presence/absence of comorbidities, showed that the CC genotype carriers had more pronounced pro-atherogenic changes vs. carriers of СА and АА genotypes. In the comorbid course of T2DM (both in combination with obesity and obesity and essential hypertension), pro-atherogenic changes were found in the carriers of the CA genotype of IRS-1 (rs2943640) polymorphism.

Conclusions. The presence of the C allele of IRS-1 (rs2943640) polymorphism in both homo-zygous and heterozygous states indicates increased risk of pro-atherogenic changes in T2DM patients with comorbid obesity and/or essential hypertension.