bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniqueness and some related estimates for Dirichlet problem with fractional Laplacian
Authors: Li Congming , Liu Chenkai 
Published: July 2023

AbstractThe non‐uniqueness of solutions of basic Dirichlet‐type problems is a surprising feature of the fractional Laplace equation. This paper establishes a somewhat sharp uniqueness condition for the fractional Laplace equation. We derive the ‐estimate for fractional Laplacian operators to better understand this phenomenon. We introduce several naturally weighted fractional Sobolev spaces and establish embedding relationships among them. These existence‐uniqueness conditions and the spaces we introduce here are intrinsically related to the fractional Laplacian and provide basic information for studying related problems.
Data from RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across <i>FGFR2</i> Alterations and Resistance Mutations
Authors: Subbiah Vivek , Sahai Vaibhav , Maglic Dejan , Bruderek Kamil , Touré B. Barry , Zhao Songping , Valverde Roberto , O'Hearn Patrick J. , Moustakas Demetri T. , Schönherr Heike , Gerami-Moayed Nastaran , Taylor Alexander M. , Hudson Brandi M. , Houde Damian J. , Pal Debjani , Foster Lindsey , Gunaydin Hakan , Ayaz Pelin , Sharon Dina A. , Goyal Lipika , Schram Alison M. , Kamath Suneel , Sherwin Cori Ann , Schmidt-Kittler Oleg , Jen Kai Yu , Ricard Fabien , Wolf Beni B. , Shaw David E. , Bergstrom Donald A. , Watters James , Casaletto Jessica B. 
Published: July 2023

<div>Abstract<p>Oncogenic activation of fibroblast growth factor receptor 2 (FGFR2) drives multiple cancers and represents a broad therapeutic opportunity, yet selective targeting of FGFR2 has not been achieved. Although the clinical efficacy of pan-FGFR inhibitors (pan-FGFRi) validates <i>FGFR2</i> driver status in <i>FGFR2</i> fusion–positive intrahepatic cholangiocarcinoma, their benefit is limited by incomplete target coverage due to FGFR1- and FGFR4-mediated toxicities (hyperphosphatemia and diarrhea, respectively) and the emergence of <i>FGFR2</i> resistance mutations. RLY-4008 is a highly selective, irreversible FGFR2 inhibitor designed to overcome these limitations. <i>In vitro</i>, RLY-4008 demonstrates >250- and >5,000-fold selectivity over FGFR1 and FGFR4, respectively, and targets primary alterations and resistance mutations. <i>In vivo</i>, RLY-4008 induces regression in multiple xenograft models—including models with <i>FGFR2</i> resistance mutations that drive clinical progression on current pan-FGFRi—while sparing FGFR1 and FGFR4. In early clinical testing, RLY-4008 induced responses without clinically significant off-isoform FGFR toxicities, confirming the broad therapeutic potential of selective FGFR2 targeting.</p>Significance:<p>Patients with <i>FGFR2</i>-driven cancers derive limited benefit from pan-FGFRi due to multiple FGFR1–4-mediated toxicities and acquired <i>FGFR2</i> resistance mutations. RLY-4008 is a highly selective FGFR2 inhibitor that targets primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs, suggesting it may have broad therapeutic potential.</p></div>
Supplementary Figure S7 from LNS8801 inhibits Acute Myeloid Leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian S , Majer Ariana D , Mercado Sophia , Estell Angela , Natale Christopher A , Sung Pamela J , Foskett J. Kevin , Carroll Martin , Ridky Todd W 
Published: July 2023

<p>Supplementary Figure S7. LNS8801-induced AML inhibition is independent of classical GPER signaling (A) Annexin V+ flow cytometry analysis of U937 cells treated with 250nM LNS8801, 10uM Forskolin, 100uM EPAC-specific cAMP (8-pCPT-2'-O-Me-cAMP), and 100uM PKA-specific cAMP (N6-benzoyl-cAMP). Cells were incubated for 24 hours. 3 replicates per condition were used. (B) Detection of intracellular calcium upon drug treatment via a spectrofluorimeter assay. Fura2-AM dye was used for detection. 25nM E2, 250nM LNS8801, 1uM Ionomycin, 2uM thapsigargin, and 100uM histamine were used. 3 replicates were used per condition.</p>
Supplementary Figure S2 from LNS8801 inhibits Acute Myeloid Leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian S , Majer Ariana D , Mercado Sophia , Estell Angela , Natale Christopher A , Sung Pamela J , Foskett J. Kevin , Carroll Martin , Ridky Todd W 
Published: July 2023

<p>Supplementary Figure S2. Human AML cell lines, primary MNC, and AML cells express GPER (A and B) Western blot of GPER expression in (A) AML cell lines, (B) normal mononuclear cells (MNC), and primary human AML samples. (C) Western blot of a primary AML sample treated with 250nM LNS8801 and/or 1uM G36. Cells were pretreated with G36 for 1 hour and treated with LNS8801 for 1 hour after pretreatment.</p>
Investigating the association between serum ADAM/ADAMTS levels and bone mineral density by mendelian randomization study
Authors: Lv Xin , Lin Yuhong , Zhang Zhilei , Li Bo , Zeng Ziliang , Jiang Xu , Zhao Qiancheng , Li Wenpeng , Wang Zheyu , Yang Canchun , Yan Haolin , Wang Qiwei , Huang Renyuan , Hu Xumin , Gao Liangbin 
Published: July 2023

Abstract
Purpose
A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) have been reported potentially involved in bone metabolism and related to bone mineral density. This Mendelian Randomization (MR) analysis was performed to determine whether there are causal associations of serum ADAM/ADAMTS with BMD in rid of confounders.

Methods
The genome-wide summary statistics of four site-specific BMD measurements were obtained from studies in individuals of European ancestry, including forearm (n = 8,143), femoral neck (n = 32,735), lumbar spine (n = 28,498) and heel (n = 426,824). The genetic instrumental variables for circulating levels of ADAM12, ADAM19, ADAM23, ADAMTS5 and ADAMTS6 were retrieved from the latest genome-wide association study of European ancestry (n = 5336 ~ 5367). The estimated causal effect was given by the Wald ratio for each variant, the inverse-variance weighted model was used as the primary approach to combine estimates from multiple instruments, and sensitivity analyses were conducted to assess the robustness of MR results. The Bonferroni-corrected significance was set at P < 0.0025 to account for multiple testing, and a lenient threshold P < 0.05 was considered to suggest a causal relationship.

Results
The causal effects of genetically predicted serum ADAM/ADAMTS levels on BMD measurements at forearm, femoral neck and lumbar spine were not statistically supported by MR analyses. Although causal effect of ADAMTS5 on heel BMD given by the primary MR analysis (β = -0.006, -0.010 to 0.002, P = 0.004) failed to reach Bonferroni-corrected significance, additional MR approaches and sensitivity analyses indicated a robust causal relationship.

Conclusion
Our study provided suggestive evidence for the causal effect of higher serum levels of ADAMTS5 on decreased heel BMD, while there was no supportive evidence for the associations of ADAM12, ADAM19, ADAM23, and ADAMTS6 with BMD at forearm, femoral neck and lumbar spine in Europeans.
Translation, cultural adaptation and evaluation of the psychometric properties of the Hamilton Anxiety Scale among a sample of Portuguese adult patients with mental health disorders
Authors: dos Santos Eugénia Raquel Pinheiro , Coelho Joana Catarina Ferreira , Ribeiro Isilda , Sampaio Francisco 
Published: July 2023

Abstract
Background
Only a few anxiety assessment tools that nurses may administer are validated forthe Portuguese population exist in the literature. Thus, this study aimed to translate and culturally adapt the Hamilton Anxiety Scale for the Portuguese population and assess its psychometric properties in a sample of adult people with mental health disorders.

Methods
This psychometric study uses a convenience sample of adult patients with mental health disorders.

Results
The confirmatory factor analysis confirmed the two factors of the original version of the tool. The internal consistency (Cronbach’s alpha) was high, at .92, as well as the inter-rater reliability (intraclass correlation coefficient) (.91).

Conclusions
The validity and reliability of the instrument are supported. However, the Hamilton Anxiety Scale should be used cautiously in the Portuguese population because the correlation with the “Anxiety State” subscale of the State-Trait Anxiety Inventory is not statistically significant.
A systematic review of the impact of the COVID-19 pandemic on the mental health of adolescents and young people with disabilities aged 15–29 years
Authors: Leung Xing Yu , Kavanagh Anne Marie , Quang Que Tien , Shields Marissa , Aitken Zoe 
Published: July 2023

Abstract
Background
The COVID-19 pandemic has exacerbated the psychological burden on young people around the world and may have disproportionately large impacts for young people with disabilities. This review aims to systematically review the quantitative evidence on the impact of the COVID-19 pandemic on the mental health of young people with disabilities and evaluate the quality of included studies.

Methods
A systematic search was conducted using 5 electronic databases. The quality of the studies was assessed using the SIGN risk of bias assessment tool. A narrative synthesis was performed to synthesize the results of included studies.

Results
The initial search yielded 1935 studies, of which two met the eligibility criteria, one longitudinal study and one cross-sectional study, both assessed to be of low quality. In the cross-sectional study, young people with intellectual and developmental disabilities self-reported an increase in mental health symptoms. The longitudinal study found no evidence of a change in mental health symptoms from pre-pandemic to during the pandemic among young people with autism spectrum disorder, although these individuals reported negative impacts of the COVID-19 pandemic on their emotional or mental health.

Conclusions
The findings of this review provide some weak evidence of a negative impact of the COVID-19 pandemic on the mental health of young people with disabilities. Importantly, the findings highlight the lack of research in this area. More research is needed to investigate the impact of the pandemic on the mental health of young disabled people, in order for governments to develop emergency preparedness plans to safeguard the well-being of this population.
Experiences of pain and pain management in advanced disease and serious illness for people from South Asian communities in Leeds and Bradford: a qualitative interview study
Authors: Clarke Gemma , Crooks Jodie , Bennett Michael I. , Mirza Zarina , OBE Ruby Bhatti , Nazar Wali , Mughal Rahila , Ahmed Shenaz 
Published: July 2023

AbstractBackgroundPain is a significant problem for many people with advanced disease or a serious illness. Culture and ethnicity can affect the experience and management of pain. However, there is limited research in South Asian communities in the UK on their experiences of pain. The aim of this study is to explore the experiences and attitudes of patients and family carers from South Asian communities about pain and its management within advanced disease or serious illness.MethodsQualitative thematic analysis based on descriptive phenomenology (Sundler et al. 2019). Qualitative semi-structured interviews with patients or family carers from South Asian communities (N = 15). Interviews were recorded, transcribed and analysed using an inductive approach. Public and Patient Involvement representatives from British South Asian communities were consulted for guidance.ResultsThere were five key themes from the interviews: The importance of communication about pain with healthcare professionals; Concerns about taking pain medication; Personal resilience, privacy and self-management; Gender, culture and pain; Home pain management as struggle and frustration.ConclusionTo improve pain management for people from South Asian communities with advanced disease or a serious illness, there are a number of important issues for healthcare professionals from palliative and primary care services to address. These include: greater awareness around people’s fears and concerns about pain medication; their potential use of alternative pain management strategies; and cultural issues such as resilience, privacy, dignity and gender roles. Effective communication between doctors, patients and family members could be improved by using a ‘cultural humility’ model; providing clear and accessible pain medication information; understanding and taking account of people with both low, and medium levels, of English language proficiency; and improving patient trust. Additionally, improvements to out of hours services could improve pain management for all patients managing their pain at home.
The burden of disabilities in Sidama National Regional State, Ethiopia: A cross-sectional, descriptive study
Authors: Tenaw Zelalem , Gari Taye , Gebretsadik Achamyelesh 
Published: July 2023

Background
Assessing the burden and describing the status of people with disabilities is very essential. The previous studies conducted about the prevalence, causes, and types of disability in Ethiopia were inconsistent and disagreeable.

Objectives
To determine the prevalence, causes, and types of disabilities in Sidama National Regional State, Ethiopia.

Methods
A house-to-house census was carried out on a total of 39,842 households in 30 randomly selected kebeles of the Dale and Wonsho districts and Yirgalem city administration, Sidama National Regional State. The data were collected using structured and pretested questionnaires via the Kobo Collect application from May 01 to 30, 2022. The analysis was performed by STATA version 16 software. After cleaning and organizing, descriptive statistics were employed to characterize the study findings.

Results
In this study, people with disabilities aged one to 80 years old were included. The mean Standard Deviation (SD) age of people with disabilities in years was 31.95 (15.33). Of 228,814 people, 1,694 were people with disabilities in Dale and Wonsho districts and Yirgalem city administration, with a prevalence of 0.74% (95% CI: 0.72, 0.76). Of the causes of disability, 61% of the disabilities were due to illness, injury, and accidents. Extremity paralysis (35.4%), vision disability (20.13%), hearing disability (19.7%), walking disability (14.7%), and cognitive disabilities (7.7%) were the identified types of disabilities.

Conclusion
This study revealed that the burden of disability is considerable in Dale and Wonsho districts and Yirgalem city administration. The vast majority of disability causes could have been avoidable. As a result, developing and implementing various strategies to raise community awareness about the causes and preventive measures is critical.
Animals are the homeless: A portrayal of sea ice dependent animals losing their natural habitat. A cognitive linguistics-oriented analysis of chosen climate change awareness raising campaigns
Authors: Majdzińska-Koczorowicz Aleksandra 
Published: July 2023

AbstractThe text aims at discussing the verbo-visual means of expression employed in three climate change-related campaigns in the context of their effectiveness. The chosen climate change awareness raising campaigns by two non-governmental organisations, EcoEduca and World Wide Fund for Nature Inc. (WWF), deal with the results of Arctic permafrost thaw resulting in the loss of sea ice dependent animals’ habitat. A cognitive linguistics oriented analysis refers to the theory of metaphor (Lakoff and Johnson 1980, Forceville 1996, Kövecses 2002, 2014), conceptual blending (Fauconnier and Turner 2003), and construal (Langacker 1987, 2008). The visual layer will also be described with reference to a grammar approach to visual communication (Kress and Van Leeuwen 1996, 2001, Machin 2010).
Application value of a nomogram model based on clinical and MRI features in predicting invasive placenta
Authors: Chen Junzhuo , Zhang Liwei , Cai Yan , Qin Haiyan , Hu Ping , Gao Chao , Hu Weizhuo , Sun Lei , Li Huan , Cao Shaodong 
Published: July 2023

Purpose:
This study was aimed at investigating the value of a nomogram model based on clinical and MRI features in predicting the risk of invasive placenta.

Methods:
Clinical and imaging data for 162 pregnant women with suspected placenta accreta spectrum disorders (PASDs) were retrospectively analyzed; data for 122 cases were used as a derivation cohort, and data from 40 cases were used as a validation cohort. In the derivation cohort, multivariable logistic regression analyses were conducted to develop a model for predicting invasive placenta. The predictive model was validated in 40 pregnant women, the nomogram was constructed, and the predictive efficiency of the model was evaluated through receiver operating characteristic curve analysis.

Results:
Ten indicators—prior caesarean delivery, loss of the placental-myometrial interface, myometrial interruption, placental/uterine bulge, marked placental heterogeneity, T2-dark intraplacental bands, abnormal vascularization of the placental bed, intraplacental abnormal vascularization, cervical invasion and bladder invasion—significantly differed between invasive and non-invasive placenta (P<0.05). The independent risk factors for invasive placenta were placental/uterine bulge, loss of the placental-myometrial interface, marked placental heterogeneity and abnormal vascularization of the placental bed. The areas under the curve for the derivation cohort and validation cohort were 0.925 and 0.974, respectively, and the diagnostic coincidence rates were 87.7% and 90.0%, respectively.

Conclusion:
The nomogram model based on clinical and MRI features effectively predicts invasive placenta.
Praenatalisan felismert magzati aortaív-rendellenességek és megszületés utáni következményeik
Authors: Tidrenczel Zsolt , P. Tardy Erika , Ladányi Anikó , Hajdú Júlia , Böjtös Ildikó , Sarkadi Edina , Simon Judit , Demeter János 
Published: July 2023

Bevezetés: Az aortaív magzati rendellenességei gyakran társulnak
a szív és egyéb szervek eltéréseivel, kromoszómaaberrációkkal és a
légcső/nyelőcső postpartum kompressziós tüneteivel. Célkitűzés:
Tanulmányunk az aortaív-rendellenességek intrauterin kimutatását, a társuló
malformációk, a genetikai eltérések és a megszületés utáni következmények
vizsgálatát célozta. Módszer: Retrospektív kohorsztanulmány egy
hazai tercier praenatalis centrumban, szülészeti és magzati kardiológiai
ultrahangvizsgálattal 2016 és 2020 között igazolt aortaív-rendellenességekben. A
genetikai vizsgálat kariotipizálással és fluoreszcens in situ
hibridizációval történt. A születés utáni következményeket a megszületést követő
24 hónapig vizsgáltuk. Eredmények: Összesen 11 380 várandós nő
vizsgálata során a magzati aortaív-eltérés prevalenciája 0,25% volt. A 28
igazolt jobb oldali aortaív-esetből 27 esetben genetikai vizsgálat is történt. A
magzati ultrahangvizsgálat során jobb oldali V jel 4 magzatnál, a többi esetben
pedig U jel volt látható, melyből 4 esetben teljes kettős aortaív igazolódott. A
jobb oldali aortaív 18 esetben (67%) volt izolált. A társult rendellenesség 3
esetben cardialis, 7 esetben extracardialis volt. A leggyakoribb szíveltérés a
Fallot-tetralógia (2/27), a leggyakoribb extracardialis eltérés a
thymushypoplasia, az arteria (a.) umbilicalis singularis és az a. subclavia
eltérései voltak. DiGeorge-szindrómát 1 esetben (3,7%) igazoltunk. A jobb oldali
V-jel-esetek 75%-a conotruncalis szívrendellenességgel társult. A terhesség
kimenetele és a postpartum következmények 24 esetben (89%) voltak ismertek. A
postnatalis diagnózis 2 esetben tért el a praenatalistól, a diagnózis
konkordanciája 93% volt. Az izolált esetek 17/18 terhességben élve születéssel
végződtek. Születés utáni kompressziós tünet 9 esetben (42,9%) alakult ki
vascularis ring miatt, 6 gyermeknél (28,6%) műtétre is szükség volt.
Következtetés: A magzati aortaív-betegségek
multidiszciplináris kórképek, melyek megfelelő ultrahangvizsgálati módszerek
alkalmazásával méhen belül felismerhetők. A társuló szervi rendellenességek
miatt alapos szülészeti és kardiológiai magzati ultrahangvizsgálat javasolt, a
genetikai betegségek miatt invazív beavatkozás és a megszületés után speciális
követés indokolt. Orv Hetil. 2023; 164(28): 1111–1120.
Investigating the Motivational and Influencing Factors on Choosing Food Items by Citizens of Tabriz, Iran
Authors: Torabi Mahin , Monajjemzadeh Farnaz , Safavizadeh Vahid , Khodayari Mohammad Taghi , Nemati Mahboob 
Published: July 2023

Abstract
Background
Due to the prevalence of nutrition-related diseases, choosing the right food items for various age groups is necessary in modern societies. Those aspects related to characteristics, society, and culture are the main motivations for food choices. Understanding the determinants of food choices can help policymakers design better strategies to promote healthy food choices in the public. This study aimed to find appropriate nutritional factors and understand the motivation for food choices. We also investigated the factors affecting the purchase and consumption of food items among citizens of Tabriz, Iran.
Methods
In this cross-sectional descriptive study, 209 valid and reliable researcher-made questionnaires were randomly distributed among volunteer citizens of Tabriz. The obtained information was analyzed in various fields, such as nutritional information, food health, price, weight control, appearance and taste, natural ingredients, ease of cooking, ease of access, and popularity of the manufacturing plant.
Results
According to the demographic findings, most participants were female (61%). The average age of the participants was 36.53 ± 7 years, and most were married. The educational level of 60% of the individuals was above the master's degree, and the income of 32.5% was reported as 20–40 million IRR. Price, health, and ease of cooking were the strongest determining factors for food choices, and the feeling of cheerfulness was the least influential factor. Also, there was a significant relationship between “nutrition and health information with different education levels”, “information and weight control with different occupational groups”, and “information and price with participant's income”.
Conclusion
The researcher-made questionnaire used in this study had high validity. So, it can be used to determine the motivational and influencing factors in choosing food items in Iran.