bluuebunny/crossref_metadata_2025_split huggingface dataset:
RESILIENT INFRASTRUCTURE: IMPACTS OF ROADS ON POPULATION AND ECONOMIC GROWTH IN KADUNA METROPOLIS, KADUNA STATE, NIGERIA
Authors: Muhammed Abdulkadir Yahaya , Sulaiman Salamatu , Bello Samira , Abdulkadir Hindatu , Baba Saadatu Umaru 
Published: July 2023

Road infrastructure is one of the critical infrastructure because it shapes the spatial structure of socio-economic activities and the well-being of the people. This study aims to bring out the correlation of the impact of road infrastructure on population and economic growth in Kaduna metropolis. A qualitative method using a thematic approach was used to collect data and analyze them. 46 participants were interviewed. From the analysis or results, two schools of thought emerged in connection with road infrastructure and population and economic growth. The first school of thought opines that road infrastructure is directly correlated with positive population and economic growth. This group is dominated by government agencies and transport functionaries. The second school of thought dominated by traders and consumers of goods did not see correlation between road infrastructure and economic growth owing to the displacement of small businesses by the roadside and the increase journey to get or purchase goods. However, irrespective of individual and/or collective views, the government of Kaduna State is trying to meet up with the sustainable development goals eight, nine and eleven which are directly connected to decent work and economic growth; industry, innovation and infrastructure and sustainable cities and communities respectively. Thus, more findings reveal many roads either rehabilitated or constructed including underpass and overpass bridges across the metropolis including a four- hectare big shopping mall. It is recommended that government should be cautious when implementing this noble idea so that less injury is/will be inflicted on small-scale business owners and consumers.
Predictive Identification of At-Risk Students: Using Learning Management System Data
Authors: Osborne J Bryan , Lang Andrew S.I.D. 
Published: July 2023

This paper describes a neural network model that can be used to detect at-risk students failing a particular course using only grade book data from a learning management system. By analyzing data extracted from the learning management system at the end of week 5, the model can predict with an accuracy of 88% whether the student will pass or fail a specific course. Data from the grade books from all course shells from the Spring 2022 semester (N = 22,041 rows) were analyzed, and four factors were found to be significant predictors of student success/failure: the current course grade after the fifth week of the semester and the presence of missing grades in weeks 3, 4, and 5. Several models were investigated before concluding that a neural network model had the best overall utility for the purpose of an early alert system. By categorizing students who are predicted to fail more than one course as being generally at risk, we provide a metric for those who use early warning systems to target resources to the most at-risk students and intervene before students drop out. Seventy-four percent of the students whom our model classified as being generally at risk ended up failing at least one course.
Faktor-Faktor yang Berhubungan dengan Keluhan Carpal Tunnel Syndrome (CTS) pada Kurir di Kota Samarinda
Authors: Wahyuni Faridah , Sultan Muhammad , Baharuddin Irfansyah 
Published: July 2023

Carpal Tunnel Syndrome (CTS) adalah penyakit pada pergelangan tangan yang menimbulkan rasa sakit, kesemutan, dan mati rasa di tangan dan pergelangan tangan. Hal tersebut disebabkan oleh adanya penekanan atau terjepitnya saraf medianus yang melalui terowongan carpal pada pergelangan tangan sehingga terjadi peradangan. Penelitian ini bertujuan untuk mencari tahu hubungan antara faktor usia, masa kerja, durasi kerja, posisi tangan yang canggung, dan penggunaan APD sarung tangan dengan keluhan Carpal Tunnel Syndrome (CTS) pada kurir di Kota Samarinda. Jenis penelitian ini adalah cross sectional dengan jumlah populasi 800 dan sampel 86 orang. Teknik pengambilan sampel menggunakan Lameshow 1997. Analisis uji bivariat pada penelitian ini menggunakan uji Spearman Rank dan Cramer’s V dengan tingkat kepercayaan (α= 0.05). Hasil peneltian menunjukkan terdapat hubungan antara usia (kurang dari 0.000), masa kerja (kuran dari 0.033), durasi kerja (kurang dari 0.001) dengan keluhan CTS pada kurir. Selanjutnya diketahui bahwa tingkat kekuatan hubungan kuat antara usia (r= 0,515), hubungan lemah antara masa kerja (r=0,230), hubungan cukup kuat antara durasi kerja (r=0,349) dengan keluhan CTS pada kurir. Hasil penelitian menggunakan uji Cramer’s V menunjukkan terdapat hubungan antara posisi canggung tangan (sig=0,000), dan tidak ada hubungan antara penggunaan APD sarung tangan (sig=0,207) dengan keluhan CTS pada kurir. Maka dapat disimpulkan terdapat hubungan antara usia, masa kerja, durasi kerja posisi tangan yang canggung dengan keluhan CTS pada kurir di Kota Samarinda. Peneliti menyarankan melakukan Peregangan otot secara mandiri dangerakan area pergelangan tangan, istirahat yang cukup, megatur durasi kerja untukmengatasi dan mengurangi terjadinya CTS.
Akidah Based Teaching Methods (Analytical, Creative, Innovative, Demonstrative, Active, Humanist) In Elementary Schools: A Literature Review
Authors: Pungki Indarto  , Jariono Gatot , Rahma Tulloh  , Haris Nugroho  , Andi Ihsan  , Uzizatun Maslikah  
Published: July 2023

The purpose of this study is to find out the initial reference and see other research perspectives as a basis for developing appropriate teaching methods in physical education. This research method uses a literature review using the google scholar search database, eric journal, and Springer. id with keywords analysis methods, creative, innovative, demonstrative, active, humanist in physical education. The articles analyzed are published from 2016 to 2021 using the following specific criteria: indexed by Scopus Q1, Q2, Q3, and Q4. Then national articles indexed sinta 1, sinta 2, sinta 3, and sinta 4. The descriptive method with population, sample, and subject is learners of primary school level. The results of this study can be concluded that the teaching method of AKIDAH-based physical education (Analysis, Creative, Innovative, Demonstrative, Active, and Humanist) is a way of teaching with an approach that is relevant to the development of the times. Choosing a learning method must pay attention to the development and growth of learners, and pay attention to humanist principles with indicators of concern. Analysis of teaching needs requires accuracy, accuracy, suitability (analysis), teaching attracts students (creativity), requires breakthroughs / new things because of the development of science and technology/era (innovative), teachers must be able to become models (demonstrative), how students become (active) in teaching and learning activities of physical education, teaching must humanize humans (humanist) pay attention to the growth and development of students.
Основні теоретичні і практичні аспекти ведення проксі-війн та гібридних воєн у сучасній світовій геополітичній та безпековій обстановці: історія, теорія, практика, форми та способи, досвід для України
Authors: Semenenko Oleh , Vodchyts Oleksandr , Tolok Polina , Mytchenko Serhii , Hetman Alevtyna , Tarasov Oleh 
Published: July 2023

Мета роботи: полягає у визначенні поглядів щодо формування основних теоретичних та практичних аспектів ведення проксі-війн та гібридних війн у сучасній світовій геополітичній та безпековій обстановці.
Метод дослідження: основними методами досліджень є методи: аналізу; синтезу; порівняння; формалізації та оцінювання матеріалу; абстрагування та кон’юнктурного аналізу (мислення).
Результати дослідження: є: аналіз основних теоретичних особливостей підготовки та ведення проксі-війн і гібридних війн; історичний аналіз формування існуючих підходів до визначення понять проксі-війн і гібридних війн; порівняльний аналіз особливостей підготовки та ведення проксі-війн і гібридних війн із визначенням їх відмінностей та схожості підходів; визначення основних етапів підготовки до розв’язання та ведення проксі-війн і гібридних війн, а також формування поглядів щодо основних етапів післявоєнного періоду; визначення інструментарію, можливих форм та способів проксі-війн і гібридних війн; формування можливих перспектив їх заміни у майбутньому.
Теоретична цінність дослідження: полягає у визначенні концептуальних та теоретико-методологічних основ дослідження щодо розвитку понять та процесів проксі-війн і гібридних війн у сучасному світовому безпековому середовищі.
Тип статті: теоретичний, описовий, практичний, методичний.
Improvement of hypertension control and left-ventricular function after cure of primary hyperparathyroidism
Authors: Karwacka Izabela , Kmieć Piotr , Kaniuka-Jakubowska Sonia , Pisowodzka Izabela , Fijałkowski Marcin , Sworczak Krzysztof 
Published: July 2023

IntroductionCardiovascular mortality is significantly higher in patients with primary hyperparathyroidism (PHPT) compared to the general population. The role of the renin-angiotensin-aldosterone system (RAAS) as a mediator of cardiovascular pathology in PHPT is unclear, as is the question whether successful parathyroidectomy (PTX) mitigates hypertension (HT), and left-ventricular (LV) dysfunction.MethodsIn 45 consecutive, hypercalcemic PHPT patients (91% female, 20 normotensive, mean age 54.6 ± 14.6), laboratory examinations, and 24 h ambulatory blood pressure monitoring (ABPM) were performed before, one and six months after successful PTX, while transthoracic echocardiography (TTE) pre- and six months post-PTX.ResultsBoth in patients with normotension (NT) and HT, lower calcemia and parathyroid hormone (PTH) as well as higher phosphatemia were observed on follow-up, while B-type natriuretic peptide, aldosterone, plasma renin activity, and aldosterone-to-renin ratios were comparable. Six months post-PTX, only in patients with HT, median 24-hour SBP/DBP decreased by 12/6 mmHg, daytime SBP by 10, and nighttime DBP by 5 mmHg. Improvement in BP was observed in approximately 78% of patients with HT. Six months post-PTX, TTE revealed: 1) decrease in median LV mass index (by 2 g/m2) and end-diastolic dimension (by 3 mm) among patients with HT; 2) normalization of global longitudinal strain in 22% of patients (comparable between those with NT and HT); 3) a mean 12.7% reduction in left-atrium volume index among patients with HT, which underlay normalization of indeterminate diastolic function in 3 out of 6 patients with HT, who exhibited it at baseline (dysfunction persisted in 2).ConclusionsPTX was shown to significantly reduce BP, LV hypertrophy and diastolic dysfunction parameters in PHPT patients with HT, and improve systolic function in all PHPT patients.
Metabolism of parathyroid organoids
Authors: Sekhar Konjeti R. , Codreanu Simona G. , Williams Olivia C. , Rathmell Jeffrey C. , Rathmell W. Kimryn , McLean John A. , Sherrod Stacy D. , Baregamian Naira 
Published: July 2023

IntroductionWe successfully developed a broad spectrum of patient-derived endocrine organoids (PDO) from benign and malignant neoplasms of thyroid, parathyroid, and adrenal glands. In this study, we employed functionally intact parathyroid PDOs from benign parathyroid tissues to study primary hyperparathyroidism (PHPT), a common endocrine metabolic disease. As proof of concept, we examined the utility of parathyroid PDOs for bioenergetic and metabolic screening and assessed whether parathyroid PDO metabolism recapitulated matched PHPT tissues.MethodsOur study methods included a fine-needle aspiration (FNA)-based technique to establish parathyroid PDOs from human PHPT tissues (n=6) in semi-solid culture conditions for organoid formation, growth, and proliferation. Mass spectrometry metabolomic analysis of PHPT tissues and patient-matched PDOs, and live cell bioenergetic profiling of parathyroid PDOs with extracellular flux analyses, were performed. Functional analysis cryopreserved and re-cultured parathyroid PDOs for parathyroid hormone (PTH) secretion was performed using ELISA hormone assays.Results and discussionOur findings support both the feasibility of parathyroid PDOs for metabolic and bioenergetic profiling and reinforce metabolic recapitulation of PHPT tissues by patient-matched parathyroid PDOs. Cryopreserved parathyroid PDOs exhibited preserved, rapid, and sustained secretory function after thawing. In conclusion, successful utilization of parathyroid PDOs for metabolic profiling further affirms the feasibility of promising endocrine organoid platforms for future metabolic studies and broader multiplatform and translational applications for therapeutic advancements of parathyroid and other endocrine applications.
Glucocorticoid dysfunction in children with severe malaria
Authors: Vandermosten Leen , Prenen Fran , Fogang Balotin , Dagneau de Richecour Pauline , Knoops Sofie , Donkeu Christiane Josiane , Nguefack Cathy Doric Piemba , Taguebue Jean-Voisin , Ndombo Paul Koki , Ghesquière Bart , Ayong Lawrence , Van den Steen Philippe E. 
Published: July 2023

IntroductionMalaria remains a widespread health problem with a huge burden. Severe or complicated malaria is highly lethal and encompasses a variety of pathological processes, including immune activation, inflammation, and dysmetabolism. Previously, we showed that adrenal hormones, in particular glucocorticoids (GCs), play critical roles to maintain disease tolerance during Plasmodium infection in mice. Here, GC responses were studied in Cameroon in children with uncomplicated malaria (UM), severe malaria (SM) and asymptomatic controls (AC).MethodsTo determine the sensitivity of leukocytes to GC signaling on a transcriptional level, we measured the ex vivo induction of glucocorticoid induced leucine zipper (GILZ) and FK506-binding protein 5 (FKBP5) by GCs in human and murine leukocytes. Targeted tracer metabolomics on peripheral blood mononuclear cells (PBMCs) was performed to detect metabolic changes induced by GCs. ResultsTotal cortisol levels increased in patients with clinical malaria compared to AC and were higher in the SM versus UM group, while cortisol binding globulin levels were unchanged and adrenocorticotropic hormone (ACTH) levels were heterogeneous. Induction of both GILZ and FKBP5 by GCs was significantly reduced in patients with clinical malaria compared to AC and in malaria-infected mice compared to uninfected controls. Increased activity in the pentose phosphate pathway was found in the patients, but this was not affected by ex vivo stimulation with physiological levels of hydrocortisone. Interestingly, hydrocortisone induced increased levels of cAMP in AC, but not in clinical malaria patients. DiscussionAltogether, this study shows that patients with SM have increased cortisol levels, but also a decreased sensitivity to GCs, which may clearly contribute to the severity of disease.
The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis
Authors: Chunder Rittika , Heider Thorsten , Kuerten Stefanie 
Published: July 2023

IntroductionMultiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). The pathophysiology of MS is complex and is said to be influenced by multiple environmental determinants, including diet. We and others have previously demonstrated how consumption of bovine milk can aggravate disease severity in MS patients, which can be explained by molecular mimicry between milk antigens and those expressed within the CNS. In this study we set out to identify alternatives to drinking cow milk which might be less detrimental to MS patients who have a genetic predisposition towards developing antibody titers against bovine milk antigens that cross-react with CNS antigens.MethodsTo this end, we screened 35 patients with MS and 20 healthy controls for their IgG reactivity against an array of animal-sourced milk, plant-based alternatives as well as individual antigens from bovine milk.ResultsWe demonstrate that MS patients have a significantly higher IgG response to animal-sourced milk, especially cow milk, in comparison to healthy donors. We also show that the reactivity to cow milk in MS patients can be attributed to reactivity against different bovine milk antigens. Finally, our correlation data indicate the co-existence of antibodies to individual bovine milk antigens and their corresponding cross-reactive CNS antigens.DiscussionTaken together, we suggest screening of blood from MS patients for antibodies against different types of milk and milk antigens in order to establish a personalized diet regimen.
Integrated bioinformatic analysis and experimental validation for exploring the key molecular of brain inflammaging
Authors: Du Zhixin , Wang Yaohui , Yang Liping , Zhang Tong , Jiang Yu , Zhang Zhenqiang 
Published: July 2023

AimsIntegrating bioinformatics and experimental validation to explore the mechanisms of inflammaging in the Brain.MethodAfter dividing the GSE11882 dataset into aged and young groups, we identified co-expressed differentially expressed genes (DEGs) in different brain regions. Enrichment analysis revealed that the co-expressed DEGs were mainly associated with inflammatory responses. Subsequently, we identified 12 DEGs that were related to the inflammatory response and used the DGIdb website for drug prediction. By using both the least absolute shrinkage and selection operator (LASSO) and random forest (RF), four biomarkers were screened and an artificial neural network (ANN) was developed for diagnosis. Subsequently, the biomarkers were validated through animal studies. Then we utilized AgeAnno to investigate the roles of biomarkers at the single cell level. Next, a consensus clustering approach was used to classify the aging samples and perform differential analysis to identify inflammatory response-related genes. After conducting a weighted gene co-expression network analysis (WGCNA), we identified the genes that are correlated with both four brain regions and aging. Wayne diagrams were used to identify seven inflammaging-related genes in different brain regions. Finally, we performed immuno-infiltration analysis and identified macrophage module genes.Key findingsInflammaging may be a major mechanism of brain aging, and the regulation of macrophages by CX3CL1 may play a role in the development of inflammaging.SignificanceIn summary, targeting CX3CL1 can potentially delay inflammaging and immunosenescence in the brain.
The effect of pore characteristics on the bonding properties of steam-cured concrete and GFRP bars
Authors: Zhang Kai , Yang Wenrui , Tang Zhiyi , Wu Weiwei , Quan Weijie , Wang Shiyu 
Published: July 2023

Steam cured concrete prefabricated components has the advantages of short construction period, less environmental pollution, convenient construction and low cost, and is widely used in high-speed railway projects. However, the changes of later strength, capillary water absorption and pore distribution led to the reduction of durability of steam-curing concrete and accelerated the damage speed of GFRP bars and bond performance between concrete and GFRP bars. In this study, the method of steam curing is adopted to simulate the damage of components caused by actual steam curing environment. The influence of pore characteristics on the bonding properties of steam cured concrete and GFRP steel bar is analyzed from both micro and macro perspectives. Analysis method combining pore characteristics with bonding strength. The test results showed that the hydration products of concrete were unaffected, but the density of the hydration products changed due to the steam curing. The porosity of the steam-cured concrete was much higher than that of the standard-cured concrete. The number of gel pores smaller than 20 nm accounted for 12.27% of the total number of pores on average, which was about twice the proportion of the gel pores of this size in the standard-cured concrete. The proportion of harmful voids with pore size of 50–200 nm and greater than 200 nm is higher than that of standard curing concrete. The bond strength of the steam-cured concrete and GFRP bars was 30% lower than that of the standard-cured concrete. With the change of the thickness of the concrete cover and the diameter of GFRP bars, the bond strength changed significantly. Based on the analysis of the test data, a predictive model of the bond strength deterioration for the steam-cured concrete and GFRP bars was established. The model fully accounted for influence factors such as the porosity, diameter, anchor length, and concrete strength.
Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
Authors: Lyu Xuejing , Wang Shaona , Zhong Jiaxin , Cai Lingzhu , Zheng Yanhui , Zhou Ying , Zhou Ying , Chen Qionghua , Li Qiyuan 
Published: July 2023

IntroductionChange in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM).MethodsTo understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnant women, including 27 GDM subjects, by employing 16S rRNA gene sequencing. Additionally, we conducted targeted metabolomics assays to validate the identified pathways with overrepresented metabolites.ResultsWe evaluated the patterns of changing abundances of operational taxonomic units (OTU) between GDM and the healthy counterparts over three timepoints. Based on the significant OTUs, we inferred 132 significantly altered metabolic pathways in GDM. And identified two overrepresented metabolites of pregnancy hormone, butyrate and mevalonate, as potential intermediary metabolites of intestinal microbiota in GDM. Finally, we validated the impacts of the intestinal microbiota on GDM by demonstrating consistent changes of the serum levels of progesterone, estradiol, butyrate, and mevalonate in an independent cohort.DiscussionOur findings confirm that alterations in the microbiota play a role in the development of GDM by impacting the metabolism of pregnancy hormones. This provides a novel perspective on the pathogenesis of GDM and introduces potential biomarkers that can be used for early diagnosis and prevention of the disease.
Moral reasoning through the eyes of persons with behavioral variant frontotemporal dementia
Authors: Antoniou Rea , Hausermann Tobias , Sideman Alissa Bernstein , Fong Kristina Celeste , Callahan Patrick , Miller Bruce L. , Kramer Joel H. , Chiong Winston , Rankin Katherine P. 
Published: July 2023

IntroductionPersons with behavioral variant frontotemporal dementia (bvFTD) can exhibit apparently antisocial behaviors. An example is their tendency to adopt utilitarian choices in sacrificial moral dilemmas, i.e. harmful actions to promote overall welfare. Moral cognition models interpret such tendencies as deriving from a lack of emotional engagement and selective impairment in prosocial sentiments.MethodsWe applied a qualitative approach to test those theoretical assumptions and to further explore the emotional experiences and values of people with bvFTD while they contemplate moral scenarios. We conducted semistructured interviews with 14 participants: 7 persons with bvFTD and 7 older healthy controls. Transcripts were coded using ATLAS.ti 5.0.ResultsDuring the moral reasoning task, persons with bvFTD reported more positive emotions than negative and showed significantly less cognitive precision in their moral reasoning compared to controls. Persons with bvFTD also organized their choices predominantly around kindness and altruism, and their responses reflected higher rule compliance. Our study showed that bvFTD persons’ utilitarian responses to moral dilemmas did not arise from an emotionally disengaged or antisocial perspective. Instead, they were underpinned by positive emotionality and prosocial values.DiscussionThese findings enrich current understandings of moral cognition and highlight the importance of incorporating mixed methods approaches in dementia research that take into consideration the viewpoint of cognitively impaired individuals