bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies
Authors: Masuda Mika , Asuka Tatsuya , Terao Naoko , Nishino Shinsuke , Ikeda Shun , Takamatsu Shinji , Kondo Jumpei , Miyoshi Eiji 
Published: February 2023

Abstract
Mac-2 binding protein (Mac-2bp) is a serum glycoprotein that contains seven N-glycans, and Mac-2bp serum levels are increased in patients with several types of cancer and liver disease. Mac-2bp glycosylation isomer has been applied as a clinical biomarker of several diseases, including liver fibrosis. In the present study, we identified fucosylated Mac-2bp in the conditioned medium of cancer cells resistant to anticancer therapies using glycoproteomic analyses. Fucosylation is one of the most important types of glycosylation involved in carcinogenesis and cancer stemness. To establish a next-generation glycan antibody for fucosylated Mac-2bp, we used fucosylation-deficient HEK293T cells to prepare reference Mac-2bp antigens and performed antibody screening. Unexpectedly, the 19-8H mAb obtained with our screen recognized 70K Mac-2bp, which is C-terminus-truncated product, rather than specifically recognizing fucosylated Mac-2bp. We performed immunocytochemistry using our novel 19-8H mAb, which resulted in strong cell surface staining of anticancer drug-resistant cancer cells. Therefore, our novel 19-8H mAb represents a valuable tool for cancer biology research that can help elucidate the biological function of 70K Mac-2bp.
Considerations in Determining the Severity of Burn Scar Contractures With Focus on the Knee Joint
Authors: Schouten Hennie , Nieuwenhuis Marianne , van der Schans Cees , Niemeijer Anuschka , van Zuijlen Paul 
Published: February 2023

Abstract
Scar contractures are a common complication after burn injuries. These contractures are characterized by impairment of joint mobility, leading to a risk for limitations during daily activities, and restrictions in participation in society. Qualifying its severity is not well established in burn care. This study, therefore, examined different approaches to determine the severity of limited mobility in the knee joint due to scar contracture.
To determine the severity of burn scar contractures development of the knee over time, the following approaches were analyzed: prevalence, the degree of limitation, the ability to perform basic daily activities, and the need for reconstructive surgery. Range of motion data of the knee joint was extracted from a 12-month prospective multicenter cohort study in the Netherlands.
Based on prevalence, mean degree of limitation, and the classification based on mathematical division, limitations in knee flexion would be seen as giving the most problems. On the other hand, when classified in terms of impact on function, limitations in extension were found to be giving most problems, although flexion limitations interfered slightly longer with the basic activities of standing, walking, and climbing stairs.
Depending on the chosen approach, the severity of burn scar contractures is projected differently. Interpreting the severity of a burn scar contracture of the knee, preferably should be based on a function-based classification system of the degree of range of motion impairment, activity limitations and participation restrictions in society. Because that does justice to the real impact of burn scar contracture on the individual burn survivor.
Vocalizing Search: How Voice Technologies Alter Consumer Search Processes and Satisfaction
Authors: Melumad Shiri 
Published: February 2023

Abstract
The effect of voice technology on how consumers search for information online is explored. Results from a field survey of consumer experiences with voice-assisted search, three controlled experiments involving dictated (vs. typed) Google searches, and a supplemental experiment (N = 10,385) find that vocalizing (vs. typing) a query leads consumers to provide more specific, detailed descriptions of what they are seeking, which in turn yield search results that they are more satisfied with. This occurs because consumers tend to be more concerned about communicating clearly when engaging with voice technology, which prompts them to think more about how they want to convey their query before saying it out loud (vs. typing it). This increased forethought leads consumers to provide more detailed descriptions of what they are searching for in vocalized queries, such as by including brand names and intended purposes of use. Finally, the increased specificity of vocalized (vs. typed) queries results in search returns that better satisfy consumers’ search goals. Implications for research on consumer–technology interactions, as well as for marketers and consumers, are discussed.
Score-Driven Modeling with Jumps: An Application to S&P500 Returns and Options
Authors: Ballestra Luca Vincenzo , D’Innocenzo Enzo , Guizzardi Andrea 
Published: February 2023

Abstract
We introduce a novel score-driven model with two sources of shock, allowing for both time-varying volatility and jumps. A theoretical investigation is performed which yields sufficient conditions to ensure stationarity and ergodicity. We extend the model to consider a time-varying jump intensity. Both an in-sample and an out-of-sample analysis based on the S&P500 time series show that the proposed methodology provides excellent agreement with observed returns, outperforming more standard Generalized Autoregressive Conditional Heteroskedasticity (GARCH) specifications with jumps. Finally, we apply our models to option pricing via risk neutralization. Results show this novel approach produces reliable implied volatility surfaces. Supplementary Materials including proofs, the derivation of the conditional Fisher information, and two figures showing additional empirical results are available online.
Test performance metrics for breast, cervical, colon, and lung cancer screening: a systematic review
Authors: Selby Kevin , Sedki Mai , Levine Emma , Kamineni Aruna , Green Beverly B , Vachani Anil , Haas Jennifer S , Ritzwoller Debra P , Croswell Jennifer M , Ohikere Kabiru , Doria-Rose V Paul , Rendle Katharine A , Chubak Jessica , Lafata Jennifer Elston , Inadomi John , Corley Douglas A 
Published: February 2023

AbstractBackgroundMultiple quality metrics have been recommended to ensure consistent, high-quality execution of screening tests for breast, cervical, colorectal, and lung cancers. However, minimal data exist evaluating the evidence base supporting these recommendations and the consistency of definitions and concepts included within and between cancer types.MethodsWe performed a systematic review for each cancer type using MEDLINE, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) from 2010 to April 2020 to identify guidelines from screening programs or professional organizations containing quality metrics for tests used in breast, cervical, colorectal, and lung cancer screening. We abstracted metrics’ definitions, target performance levels, and related supporting evidence for test completeness, adequacy (sufficient visualization or collection), accuracy, and safety.ResultsWe identified 11 relevant guidelines with 20 suggested quality metrics for breast cancer, 5 guidelines with 9 metrics for cervical cancer, 13 guidelines with 18 metrics for colorectal cancer (CRC), and 3 guidelines with 7 metrics for lung cancer. These included 54 metrics related to adequacy (n = 6), test completeness (n = 3), accuracy (n = 33), and safety (n = 12). Target performance levels were defined for 30 metrics (56%). Ten (19%) were supported by evidence, all from breast and CRC, with no evidence cited to support metrics from cervical and lung cancer screening.ConclusionsConsiderably more guideline-recommended test performance metrics exist for breast and CRC screening than cervical or lung cancer. The domains covered are inconsistent among cancers, and few targets are supported by evidence. Clearer evidence-based domains and targets are needed for test performance metrics.RegistrationPROSPERO 2020 CRD42020179139
Work, music, and friendship
Authors: White Patricia 
Published: February 2023

ABSTRACTDrawing extensively on letters sent to me by him over fifty years, this paper tries to present a vivid picture of Paul Hirst in different aspects of his life. The first section covers the huge amount of work he did at the universities of London and Cambridge—in teaching and writing philosophy of education, high-level administrative university responsibilities, and involvement in national education policy. This is followed by a glimpse into his passion for music, especially opera. Final sections show him as an academic mentor and friend.
Does a tragedy of the commons due to individual competition arise from genetically fixed traits or plastic traits in dryland wheat? An experimental verification
Authors: Zhu Li , Xiang Jun , Zhang Da-Yong , Wang Wei , Zhu Shuang-Guo , Wang Bao-Zhong , Yang Li-Yuan , Li Meng-Ying , Xiong You-Cai 
Published: February 2023

AbstractGrowth redundancy, the overgrowth of resource-foraging organs in crop stands, is often detrimental to yield and is thus called a ‘tragedy of the commons’. A tragedy can also arise owing to the plastic overproduction of competitive structures when intra-variety individuals forage in close proximity to each other. However, little is known about the sensitivity of crop varieties and resource availability to this ‘plastic’ tragedy. Pot experiments were designed to investigate this issue. The root competition environment was imposed by growing two plants of the same variety in mesh and plastic partitions. Two wheat varieties (old Monkhead and modern 92-46) were used, and two resource levels were established. Compared with 92-46, Monkhead allocated more biomass to stems and leaves and concurrently less to seeds. We identified intra-variety neighbour effects only in 4 out of 24 allometric comparisons with a small magnitude. Allometric data also revealed a lowered response to fertilizer addition in 92-46 than in Monkhead. Based on a limited sample size, our results revealed a trade-off between above-ground vegetative growth and crop yield. This trade-off resulted in a tragedy of the commons in old Monkhead and enhanced yields in modern 92-46. The tragedy of the commons in wheat may generally arise from genetically fixed traits in terms of growth redundancy in old varieties, rather than from the plastic behaviour of individuals. Modern 92-46 may adopt a conservative strategy of resource use, whereas old Monkhead employs an exploitative strategy. Our findings highlight breeders should select genotypes with low individual competitiveness.
Effects of irradiation on cumulative mortality in mice: shifting toward a younger age of death
Authors: Fujimichi Yuki , Sasaki Michiya , Yoshida Kazuo , Iwasaki Toshiyasu 
Published: February 2023

AbstractRecently, the question of whether cancer risk is only accelerated but not increased by radiation exposure has been raised. To explore this matter, we analyzed whether the cumulative mortality of irradiated mice could be explained by x-axis (age) shifted cumulative mortality of nonirradiated mice. We reanalyzed publicly available data on observed cumulative mortality or prevalence in irradiated female B6C3F1 mice that lived their entire lifespan. The results showed that the irradiated curve was well matched to uniformly shifted nonirradiated curve for the cumulative mortality of all causes of death but not for the cumulative mortality of all solid tumors and prevalence of ovarian tumors as is. After adjusting lifetime mortalities, it was also well matched for all solid and ovarian tumors. The shifted days by irradiation were 71–116 days for all causes of death, 56–135 days for all solid tumors, and 41–140 days for ovarian tumors in the 1.9 Gy-irradiated group. The response was switched between irradiation at 35 and 105 days consistently for all the above indexes, supporting the hypothesis that radiation sensitivity differs between juvenile and adults. The shifted days of all causes of death showed a tendency of linear response to dose. This concept of shifting the age of death can be applied not only for all cause of death but also for mortality of all solid tumors after adjusting the magnitude. These findings contribute to the discussion on the application of the ‘shifting age of death’ concept to radiation protection.
Latent network models to account for noisy, multiply reported social network data
Authors: De Bacco Caterina , Contisciani Martina , Cardoso-Silva Jonathan , Safdari Hadiseh , Lima Borges Gabriela , Baptista Diego , Sweet Tracy , Young Jean-Gabriel , Koster Jeremy , Ross Cody T , McElreath Richard , Redhead Daniel , Power Eleanor A 
Published: February 2023

AbstractSocial network data are often constructed by incorporating reports from multiple individuals. However, it is not obvious how to reconcile discordant responses from individuals. There may be particular risks with multiply reported data if people’s responses reflect normative expectations—such as an expectation of balanced, reciprocal relationships. Here, we propose a probabilistic model that incorporates ties reported by multiple individuals to estimate the unobserved network structure. In addition to estimating a parameter for each reporter that is related to their tendency of over- or under-reporting relationships, the model explicitly incorporates a term for ‘mutuality’, the tendency to report ties in both directions involving the same alter. Our model’s algorithmic implementation is based on variational inference, which makes it efficient and scalable to large systems. We apply our model to data from a Nicaraguan community collected with a roster-based design and 75 Indian villages collected with a name-generator design. We observe strong evidence of ‘mutuality’ in both datasets, and find that this value varies by relationship type. Consequently, our model estimates networks with reciprocity values that are substantially different than those resulting from standard deterministic aggregation approaches, demonstrating the need to consider such issues when gathering, constructing, and analysing survey-based network data.
The determinants of Airbnb prices in New York City: a spatial quantile regression approach
Authors: Bernardi Mauro , Guidolin Mariangela 
Published: February 2023

AbstractIn this paper, we study the price determinants of Airbnb rentals, for the case of New York City, by developing a new dataset, which combines attributes of the property and of the related service, with other information available as open data. This dataset is employed within a spatial quantile semiparametric regression model, able to handle the intrinsic heterogeneity of house prices. The results confirm that property and service attributes play a significant role in determining rental prices, while some variables exert a different impact on prices in magnitude and sign, depending on the quantile considered.
A novel survey for young substellar objects with the W-band filter IV: detection and characterization of low-mass brown dwarfs in Serpens Core
Authors: Dubber Sophie , Biller Beth , Albert Loïc , Liu Michael , Jose Jessy , Zhang Zhoujian , Chen Wen-Ping , Lalchand Bhavana , Damian Belinda , Sharma Tanvi , Allers Katelyn 
Published: February 2023

ABSTRACT
We present spectroscopic confirmation of nine M5 or later Serpens Core candidate members, identified using a combination of CFHT WIRCam photometry and IRTF SpeX spectroscopy. Through spectral fitting, we find that the latest of these nine candidate members is best fit by an L0 spectral standard (in the range of M8–L2), implying a mass of ∼0.01–0.035M⊙. If confirmed as a cluster member, this would be one of the lowest mass Serpens Core objects ever discovered. We present analysis of the physical properties of the sample, as well as the likely membership of the candidate Serpens Core members.
A comptonized fireball bubble: physical origin of magnetar giant flares
Authors: Zhang Zhao Joseph , Zhang Bin-Bin , Meng Yan-Zhi 
Published: February 2023

ABSTRACT
Magnetar giant flares (MGFs) have been long proposed to contribute at least a subsample of the observed short gamma-ray bursts (GRBs). The recent discovery of the short GRB 200415A in the nearby galaxy NGC 253 established a textbook-version connection between these two phenomena. Unlike previous observations of the Galactic MGFs, the unsaturated instrument spectra of GRB 200415A provide for the first time an opportunity to test the theoretical models with the observed γ-ray photons. This paper proposed a new readily fit-able model for the MGFs, which invokes an expanding fireball Comptonized by the relativistic magnetar wind at photosphere radius. In this model, a large amount of energy is released from the magnetar crust due to the magnetic reconnection or the starquakes of the star surface and is injected into confined field lines, forming a trapped fireball bubble. After breaking through the shackles and expanding to the photospheric radius, the thermal photons of the fireball are eventually Comptonized by the relativistic e± pairs in the magnetar wind region, which produces additional higher-energy gamma-ray emission. The model predicts a modified thermal-like spectrum characterized by a low-energy component in the Rayleigh-Jeans regime, a smooth component affected by coherent Compton scattering in the intermediate energy range, and a high-energy tail due to the inverse Compton process. By performing a Monte-Carlo fit to the observational spectra of GRB 200415A, we found that the observation of the burst is entirely consistent with our model predictions.
Accelerating declines of North America’s shorebirds signal the need for urgent conservation action
Authors: Smith Paul A , Smith Adam C , Andres Brad , Francis Charles M , Harrington Brian , Friis Christian , Morrison R I Guy , Paquet Julie , Winn Brad , Brown Stephen 
Published: February 2023

Abstract
Shorebirds are declining to a greater extent than many other avian taxa around the world. In North America, shorebirds, along with aerial insectivores and grassland birds, have some of the highest proportions of declining species of any group. Here, we apply a new hierarchical Bayesian model to analyze shorebird migration monitoring data from across North America, from 1980 to 2019, and present the most recent available estimates of trends for 28 species. Point estimates for survey-wide trends in abundance were negative for 26 of 28 species (93%). Despite challenges with low precision associated with migration count data, trends for 19 species had 95% credible intervals that were entirely negative. More than half of the species were estimated to have lost &gt;50% of their abundance. Furthermore, estimated rates of decline have accelerated during the last three generations for most species. Point estimates of trend were more negative for 18 species (64%) during the most recent three-generation period in comparison to the previous three-generation period. Many species now exceed international criteria for threatened species listing. The analytic approach used here allows us to model regional variation in trends, although survey coverage and strength of inference were greatest in the eastern portions of North America (east of 100°W). We found the greatest declines at staging sites along the Atlantic Coast from North Carolina to Nova Scotia, and lesser declines along the Gulf Coast and in the midcontinental United States. The declines in shorebird populations reported here are worrisome and signal the urgent need for conservation action. In addition, it would be beneficial to validate these results through the collection and analysis of complementary data, and to initiate demographic studies throughout the annual cycle to determine where and when declines are most likely to originate. This improved information will allow for the development of more targeted efforts to reverse declines through conservation action.
Magic in the Ancient World
Authors: Maxwell-Stuart Peter 
Published: February 2023

Abstract
This chapter explores early examples of the witch figure and magician, and the development of magic as a practice, by focusing on the material evidence from the earliest clay tablets that recorded spells through to the use of papyrus rolls in the Hellenic world and the creation of magical objects. How did magicians go about their work? How did the development of writing and writing surfaces shape the magical tradition? Furthermore, what did the ancient Mesopotamians, Egyptians, Greeks, and Romans hope to achieve through magic, and what does this tell us about ancient societies? The chapter also describes the relationship between religion and magic, as understood at the time, and how their definitions changed with the rise of Christianity.
The Demonologists
Authors: Sharpe James 
Published: February 2023

Abstract
The importance of this chapter is in describing how medieval and Renaissance concerns about magic and manifestations of heresy were twisted into the notion of satanic witchcraft. While the promulgation of laws against witchcraft across Europe in the sixteenth century created the mechanism for the widespread persecution of suspected witches, during the previous century demonologists had begun sowing the seeds of concern through their published writings. Following the Reformation, Protestant and Catholic demonologists found common cause (while still blaming each other) in promoting and shaping the campaign. That said, there was significant divergence of opinion amongst the demonologists as to the reality of the powers attributed to witches.
The World of Popular Magic
Authors: Davies Owen 
Published: February 2023

Abstract
With an emphasis on the surviving material culture, this chapter examines the diverse array of magical rituals and spells that were used across Europe from the early modern period to the twentieth century. This is one of the most underexplored aspects of the history of witchcraft and magic. The chapter sets out two main areas of popular magic. First, domestic and personal protection against witches and the spirit world; and, secondly, rituals for magical healing. Basic concepts such as sympathetic magic and the doctrine of signatures are explained. The evidence shows the continued widespread fear of witches in nineteenth- and twentieth-century Europe.
The Rise of Modern Magic
Authors: Davies Owen 
Published: February 2023

Abstract
The occult revival of the late nineteenth century and the rise of Wicca and the numerous modern magical traditions of the twentieth century are the focus of this chapter. But it begins by assessing the influence of Freemasonry and spiritualism. There is an emphasis on the role of imagery in the formation of ritual magicians’ self-identity, and in shaping public perceptions. What do the photographic portraits of Golden Dawn members, such as Samuel Liddell Mathers, in full ritual dress tell us about their ideas and beliefs? The numerous posed photographs of Aleister Crowley are revealing of the different facets of his magical identity. Group photographs and action shots of Wiccans performing magic played an important role in shaping public understanding of modern witchcraft in the 1960s and 1970s. Images of nudity, dancing, and outdoor worship, all provided striking motifs of the nature of magic and the magic of nature.