bluuebunny/crossref_metadata_2025_split huggingface dataset:
Confronting policy myopia: Short‐term government policy and information seeking behaviors in rural Thailand
Authors: Setthasuravich Prasongchai , Kato Hironori 
Published: January 2025

AbstractShort‐term policy (STP) has attracted considerable attention as a form of time‐related public policy and is typically used to solve urgent problems. The objective of this study, which considers STP as policy myopia from an information science perspective, is to discuss the challenges encountered during the STP policymaking process and their impact on the effectiveness of information dissemination to the public, and the barriers to information seeking behavior (ISB) among rural residents during STP implementation, alongside their methods of seeking STP information. This study uses the first car buyer policy (FCBP) in Thailand as a case study. Semistructured interviews were conducted with five government officials and 39 rural residents in December 2019. A qualitative analysis, facilitated by ATLAS.ti software, involved an iterative coding process to develop thematic categories that emerged directly from the data, ensuring a grounded understanding of ISB and policy dissemination challenges. The findings of this study show that the dissemination of government information and its consequences are the main issues in the STP process. They also reveal that the ISB of rural residents is related to limited time resources, concerns about government policy, and substandard Internet access as obstacles or intervening factors. Based on these findings, this study provides theoretical and policy implications that can enrich STP and ISB in developing countries. From a theoretical standpoint, it introduces a novel conceptual framework that integrates policy myopia within the information behavior model, highlighting how STP influences ISB, particularly in rural areas. Additionally, this study provides practical insights for policymakers by identifying key barriers to information access and offering strategies to enhance communication effectiveness. The insights gained from this study can inform future policy design, showing that governments should enhance information dissemination, adapt communication channels to audience needs, tailor information to local contexts, and support active ISB among rural residents through targeted awareness campaigns and infrastructure improvements.
Segmental Megaesophagus Secondary to Extraluminal Esophageal Stenosis Caused by Transitional Seventh Cervical Vertebra and Supernumerary Ribs in a Goat
Authors: Means Kari L. , Zukeran‐Kerr Kekauilani , Le Kayla , Yap Seng Wai , Brown Kelsey , Clarke Lorelei 
Published: January 2025

ABSTRACTA 4‐year‐old Nigerian Dwarf wether presented for chronic regurgitation and cervical swelling of three years duration. Physical examination revealed a large ventral cervical mass. The goat made repeated attempts to swallow and regurgitate, but the mass did not change significantly in size. Cervical radiographs revealed segmental esophageal dilation to the level of the thoracic inlet. CT revealed a transitional seventh cervical vertebra with fused right and left ribs, resulting in extramural esophageal compression and obstruction at the level of the thoracic inlet. This is the first report of a cervical rib causing megaesophagus in a goat.
A step-by-step technical report on the novel 'PREMADE Protocol' for fabricating acrylic provisional prostheses for all-on-4 treatment concept
Authors: Pitino Alberto , Gianfreda Francesco , Dolci Alessandro , Fossati Edoardo , Voghera Gloria , Bollero Patrizio , Gargari Marco , Karimi Dora , Martelli Mirko 
Published: January 2025

Background: This technical report describes how to use a prosthetic protocol with a standardized immediate and fixed prosthesis that is the same for all patients. The prosthesis called “PREMADE” is adapted to various arch sizes (narrow, regular, and wide, with uniform teeth in all cases). This aim is to obviate the need for all laboratory procedures following the positioning of the implant.
Case Presentation: This report details the application of the PREMADE protocol in a clinical setting. It illustrates its use in a patient requiring immediate dental implant loading, highlighting the protocol’s step-by-step technical nuances. The case underscores the protocol’s efficiency in reducing laboratory phases and chair time, facilitated by its innovative approach of utilizing a standardized prefabricated arch adaptable to various jaw sizes. The procedure’s success is evident in the minimized patient discomfort and improved osseointegration, attributed to the protocol’s stability and micromotion control.
Conclusions: The PREMADE protocol signifies a transformative advancement in immediate dental implant loading, enhancing procedural efficiency and patient outcomes. Its application demonstrates the potential to reduce procedural complexity and time, thereby improving the patient experience. However, further research is required to establish its universal applicability and to compare it with other immediate loading protocols. The future integration of this protocol in all-on-4 rehabilitation could revolutionize the prosthetic phase, making advanced dental treatments more accessible.
The use of ozone therapy for the treatment and post-surgical management of patients treated with bilateral extraction of the included third mandibular molars
Authors: Memè Lucia , Pizzolante Tommaso , Saggiomo Anna Pia , Plaku Dervish , Inchingolo Alessio Danilo , Inchingolo Francesco , Rastelli Sofia 
Published: January 2025

The use of ozone in medicine and dentistry is well-supported in the scientific literature, particularly for its antibacterial, antiviral, anti-inflammatory, and anti-edema effects. These benefits are achieved through reductions in pro-inflammatory substances, stimulation of neoangiogenesis, and enhanced production of antioxidant enzymes. Additionally, ozone is pain-relieving by inactivating algogenic mediators and inducing endorphin release. Although ozone application devices are standard in conventional medicine, they are less so in dentistry and often have reduced performance. This study aims to evaluate the effectiveness of a specific ozone therapy device in managing postoperative pain and promoting healing in patients undergoing impacted third-molar extractions. Materials and methods: Patients scheduled for the extraction of impacted third molars were enrolled in a randomized split-mouth study to receive either ozone therapy or conventional antibiotic treatment. The Visual Analog Scale (VAS) assessed pain intensity and healing progress. Results: Patients treated with ozone therapy reported significantly lower pain levels and demonstrated qualitatively improved healing compared to the control group, with statistical significance. Conclusions: The study supports the use of ozone therapy in routine dental surgical practice, highlighting its favorable cost/benefit profile. Ozone therapy can be beneficial for impacted third-molar surgeries and broader applications in oral surgery.
Keywords: Ozone therapy in dentistry, OZONE DTA equipment, Third molar
extraction and soft tissue healing.
Minimal invasive sinus elevation (MISE), a different approach for maxillary sinus lift surgery
Authors: Pizzolante Tommaso , Saggiomo Anna Pia , Principi Martina , Jorida Jubani , Mema Mattia , Jolla Ervis , Rastelli Sofia 
Published: January 2025

Aim: The maxillary sinus lift is a crucial surgical procedure performed to increase the vertical height of the remaining bone, often required before implant placement.
Several techniques are used to approach the maxillary sinus, with varying results.
Among them, it is possible to mention the minimal invasive sinus elevation (MISE)
technique.
Methods: This paper provides a comprehensive review of the MISE technique, its materials, and surgical methods. It analyzes the outcomes compared to conventional methods and discusses its applicability in different clinical scenarios.
Results: The MISE technique has proven effective in increasing bone height with a lower risk of membrane perforation compared to traditional methods. It offers high implant success rates and minimal post-operative complications, with strong patient outcomes regarding bone regeneration and implant stability. This section will analyze these results with both quantitative and qualitative evaluations.
Conclusions: The MISE technique notably improves sinus lift procedures, providing a minimally invasive method with reliable clinical results. Its predictability and lower risk of membrane perforation make it well-suited for implant surgeries involving sinus elevation. Future studies should explore long-term results and refine the technique for broader clinical use.
Fostering the Physical-Literacy Development of Individuals Experiencing Disability Through the Use of PLayTubs: A Pilot Study
Authors: Stacey Kiana , Gosse Nicholas , Pushkarenko Kyle 
Published: January 2025

Physical literacy (PL) is increasingly being implemented as a means for holistic development for children and youth. Despite this, children experiencing disabilities and their families continue to face barriers that impede participation in physical activities and subsequent PL development. To empower families to actively engage in their PL development, this study sought to provide an accessible, home- and play-based, parent-facilitated intervention, namely, PLayTubs. The purpose was to explore parents’ subjective understanding, involvement, and attitudes toward facilitating physical activity opportunities contributing to PL development through this intervention. Four parents with a child (<12 years old) diagnosed with a developmental impairment participated in a 10-week PLayTub experience. Data were collected via semistructured interviews with parents and their children. Making use of an interpretive description methodology and an ecological-dynamics conceptual framework, this study resulted in three themes: (a) a catalyst for autonomy, (b) more than just movement, and (c) an accessible alternative. Parents found that PLayTubs fostered autonomous participation and individual agency, enhanced connections and togetherness, and allowed for the creation of meaningful experiences with physical activity. These positive insights demonstrate the benefit of home-based interventions for this population and highlight the need for larger studies in the future.
Immediate and Short-Term Effect of Scapula Retraction Exercises on Subacromial Space: Do We Have Enough Evidence in Patients With Subacromial Pain?
Authors: Eraslan Leyla , Yar Ozan , Huri Gazi , Duzgun Irem 
Published: January 2025

Context: Limited information exists regarding the immediate and short-term effects of scapula retraction exercises (SREs) on acromiohumeral distance (AHD) in subacromial pain syndrome (SPS). This study’s 2 main objectives were to investigate (1) the immediate effect of the SRE on AHD at varying shoulder abduction angles in patients with SPS and healthy controls and (2) the effect of the 8-week SRE program on AHD in patients with SPS. Design: Cross-sectional and pre–post intervention designs were utilized on this study. Methods: Twenty-one patients with SPS and age-matched healthy controls were included. First, AHD at 0°, 30°, 45°, 60°, and 90° of active shoulder abductions were recorded during (1) resting upper quadrant posture and (2) while participants were performing SREs. Patients then underwent an 8-week progressive SRE program. AHD measures, pain intensity (visual analog scale), and disability (Shoulder Pain and Disability Index) were recorded at baseline and 8 weeks. AHD were analyzed using mixed-model analyses of variance. Pain and disability were analyzed using paired samples t test. Results: The immediate effect of the SREs revealed a significant angle-by-exercise-by-group interaction for the AHD values (F3,155 = 3.956, P = .009, ). Pairwise comparisons yielded that the SRE increased AHD values in patients with SPS (P < .05), yet it did not affect healthy controls (P > .05). Besides, the SRE program revealed a significant angle-by-time interaction for the AHD values (F3,054 = 9.476, P < .001, ). AHD increased at all elevation angles, and pain and disability improved over time (P < .05). Conclusion: SREs immediately affect AHD in patients with SPS but not in healthy populations. Moreover, SREs applied in progressive abduction angles improve pain, functionality, and AHD values in patients with SPS.
Pulmonary aspiration after activated charcoal in unintentional acute poisonings in childhood
Authors: Ramirez-Romero Johanna , Cifuentes Zamalloa Claudia , Elorza Elena Amaia , Azkunaga Beatriz , Mintegi Santiago 
Published: January 2025

IntroductionAlthough the administration of activated charcoal (AC) is considered safe, the associated risk of pulmonary aspiration explains certain reluctance of physicians to use this procedure. The objective of this study was to analyse the rate of pulmonary aspiration in children receiving AC after accidental ingestion of a toxic substance.MethodsWe carried out a substudy of a multicentre prospective registry-based cohort study including children presenting with acute poisoning to 58 paediatric emergency department (EDs) members of the Spanish Society of Pediatric Emergency Medicine between 2008 and 2022 on certain previously designated days.ResultsDuring the study period, we registered 1983 episodes corresponding to accidental ingestion of a toxic substance in patients less than 7 years old. Of them, 517 (26.1%) received AC, 167 (32.3%) via a nasogastric tube. In most cases, the substance swallowed was a medication (paracetamol, psychotropics, and cough and cold medications accounting for 91.6% of episodes) and 419 children (81%) were asymptomatic on arrival to the ED. Gastric lavage was performed in 81 cases (15.7%). After receiving AC, 448 children (86.6%) were managed as outpatients (329 after a less than 24-hour stay in the ED observation unit).All patients did well, and no cases of pulmonary aspiration were reported, regardless of the route of AC administration.ConclusionsThe administration of AC to children after accidental ingestion of a toxic substance seems to be safe, regardless of the route of administration. Efforts are required to improve the ED management of these children.
Combinations of substances contributing to death among overdose decedents in Maryland (2020–2021)
Authors: Tomko Catherine , Park Ju Nyeong , Amin-Esmaeili Masoumeh , Schneider Kristin , Susukida Ryoko , Byregowda Himani , Parnham Taylor , Johnson Renee M 
Published: January 2025

BackgroundIn 2020, Maryland had the fourth-highest opioid overdose mortality rate in the USA. We describe substances identified in postmortem toxicology screening and designated as cause of death (COD) for overdose decedents in Maryland, including specific combinations of substances designated as COD.MethodsWe performed a retrospective analysis of N=5442 adult overdose decedents (ie, manner of death unintentional or undetermined) in Maryland between January 2020 and December 2021. Overdose mortality data from the State Unintentional Drug Overdose Reporting System. Substances were categorised into five major categories: opioids, alcohol, psychostimulants, sedative-hypnotics and psychotropic drugs. Opioids were further divided into prescription opioids (eg, oxycodone, methadone, tramadol) and illicit opioids (eg, illicitly manufactured fentanyl (IMF), heroin).ResultsOpioids were present in 93% of cases and designated as COD for 92%. IMF was the predominant opioid designated as COD (82% of cases), whereas heroin was COD in only 3%. Psychostimulants, predominantly cocaine, were present in 48% of cases and designated as COD in 41%. Opioids alone were COD in 39% of cases, opioids and psychostimulants in combination were COD for 27%, followed by opioids and alcohol (9%), opioids, alcohol and psychostimulants (6%), and opioids and sedative-hypnotics (4%).ConclusionsIMF is, by far, the leading cause of overdose in Maryland. For more than one-quarter of decedents, opioids and psychostimulants in combination were COD. Specific drug combinations have implications for public health surveillance and harm reduction efforts to keep people who use drugs safer from a volatile drug market and potential fatal overdose.
Aarskog-Scott syndrome: a clinical study based on a large series of 111 male patients with a pathogenic variant inFGD1and management recommendations
Authors: Jeanne Médéric , Ronce Nathalie , Remizé Solène , Arpin Stéphanie , Baujat Geneviève , Breton Sylvain , Petit Florence , Vanlerberghe Clémence , Coeslier-Dieux Anne , Manouvrier-Hanu Sylvie , Vincent-Delorme Catherine , Khau Van Kien Philippe , Van-Gils Julien , Quélin Chloé , Pasquier Laurent , Odent Sylvie , Demurger Florence , Laffargue Fanny , Francannet Christine , Martin-Coignard Dominique , Afenjar Alexandra , Whalen Sandra , Verloes Alain , Capri Yline , Delahaye Andrée , Plaisancié Julie , Labrune Philippe , Destree Anne , Maystadt Isabelle , Ciorna Monferrato Viorca , Isidor Bertrand , Vincent Marie , Jean Marçais Nolwen , Nambot Sophie , Schaefer Elise , El Chehadeh Salima , Lespinasse James , Collignon Patrick , Busa Tiffany , Philip Nicole , Willems Marjolaine , Planes Marc , Vanakker Olivier M , Lambert Laetitia , Leheup Bruno , Mathieu-Dramard Michèle , Morin Gilles , Dieterich Klaus , Ginglinger Emmanuelle , Bayat Allan , Balasubramanian Meena , Dauriat Benjamin , Haye Damien , Amiel Jeanne , Rio Marlène , Cormier-Daire Valérie , Toutain Annick 
Published: January 2025

BackgroundAarskog-Scott syndrome (AAS) is a rare condition with multiple congenital anomalies, caused by hemizygote variants in theFGD1gene. Its description was based mostly on old case reports, in whom a molecular diagnosis was not always available, or on small series. The aim of this study was to better delineate the phenotype and the natural history of AAS and to provide clues for the diagnosis and the management of the patients.MethodsPhenotypic characterisation of the largest reported AAS cohort, comprising 111 male patients with proven causative variants inFGD1, through comprehensive analyses of clinical data including congenital anomalies, growth and neurodevelopment. Review of photographs and radiographs by experts in dysmorphology and skeletal disorders.ResultsThis study refines the phenotypic spectrum of AAS, with the description of new morphological and radiological features, and refines the prevalence of the features. Short stature is less frequent than previously reported and has a prenatal onset in more than half of the patients. The growth has a specific course with a catch-up during the first decade often leading to low-normal stature in adulthood. Whereas intellectual disability is rare, patients with AAS have a high prevalence of specific learning difficulties and attention hyperactivity disorder. In light of this better knowledge of AAS, we provide management recommendations.ConclusionA better knowledge of the natural history and phenotypic spectrum of AAS will be helpful for the clinical diagnosis and for the interpretation ofFGD1variants using a retrophenotyping strategy, which is becoming the most common way of diagnosis nowadays. Recommendations for care will improve the management of the patients.
Efgartigimod efficacy and safety in refractory myasthenia gravis: UK’s first real-world experience
Authors: Moniz Dionísio Joana , Ambrose Philip , Burke Georgina , Farrugia Maria Elena , Garcia-Reitboeck Pablo , Hewamadduma Channa , Hill Marguerite , Howard Robin S , Jacob Saiju , Kullmann Dimitri , Leite Maria Isabel , Miller James , Pinto Ashwin , Pritchard Jane , Riswick Thomas , Sathasivam Sivakumar , Thambirajah Narmathey , Viegas Stuart , Norwood Fiona , Spillane Jennifer 
Published: January 2025

BackgroundWe report our experience of patients with generalised myasthenia gravis (gMG) treated with efgartigimod, an neonatal Fc receptor antagonist, under the Early Access to Medicine Scheme (EAMS) in the UK.MethodsData from all UK patients treated with efgartigimod under the EAMS July 2022 to July 2023 were collected retrospectively. Efgartigimod was administered as per the ADAPT protocol (consisting of a treatment cycle of four infusions at weekly intervals with further cycles given according to clinical need).Results48 patients with acetylcholine receptor antibody-positive gMG were treated in 12 centres. Most (75%) were female and most had a disease duration of over 10 years. The average MG-Activities of Daily Living (ADL) score at baseline was 11.2. Most (72.9%) patients had undergone thymectomy. 77.0% were taking prednisolone at baseline. All patients had used non-steroidal immunosuppressant treatments, the average number tried was 2.6 (range 1–6). 51% had received rituximab. 54.2% of patients required regular intravenous immunoglobulin/plasma exchange.75% of patients had a mean reduction in the MG-ADL of≥2 points in the first cycle and this remained stable throughout the study. The mean intracycle reduction in the MG-ADL score in the first, second, third and fourth cycles were −4.6 to –3.9, −3.4 and −4.2, respectively. Side effects were generally mild. No rescue treatments were required. At the end of the study, 96% of patients remained on efgartigimod.ConclusionEfgartigimod is a safe and effective treatment for patients with refractory, treatment-resistant gMG.
Interrelationship between chemsex engagement and PrEP (pre-exposure prophylaxis) experience in men who have sex with men: a community-based cross-sectional study
Authors: Wong Ngai Sze , Chung Sze Long , Lee Krystal Chi-Kei , LEE Shui-Shan 
Published: January 2025

BackgroundChemsex engagement is known to be associated with higher-risk sexual behaviour, HIV and sexually transmitted infection (STI). To reduce HIV infection risk, pre-exposure prophylaxis (PrEP) is increasingly used in the men who have sex with men (MSM) community. This study aims to examine the interrelationship between chemsex engagement and PrEP use in MSM.MethodsThis is a cross-sectional study with the recruitment of MSM in the community in Hong Kong. Participating MSM were invited to complete an online survey which included PrEP (experienced or naïve) use, chemsex engagement history and HIV test results. Chemsex engagement referred to use of specific drugs (methamphetamine and/or gamma-hydroxybutyrate) before and/or during sex. Characteristics of MSM with and without history of chemsex engagement were examined in bivariable and multivariable logistic regression. In a case-control analysis with a 1:1 ratio of PrEP-naïve and PrEP-experienced MSM, the association of chemsex engagement with history of PrEP use was examined in bivariable and multivariable logistic regression.ResultsBetween February 2022 and January 2024, 338 eligible MSM were recruited. A higher proportion of MSM engaged in chemsex reported history of PrEP use and group sex. Prevalence of ever chemsex engagement was significantly higher in PrEP-experienced (29%) than PrEP-naïve MSM (9%) (adjusted OR=2.69, 95% CI 1.28 to 5.67), after adjustment for confounders of age, history of STI testing, multiple sex partnership and inconsistent condom use. The history of chemsex engagement in the past 6 months was associated positively with ever and recent (6 months) use of PrEP. Five out of seven PrEP-naïve MSM who had engaged in chemsex in the past 6 months indicated their intention to take PrEP.ConclusionsChemsex engagement was positively associated with PrEP use while most of the PrEP-naïve MSM who had recently engaged in chemsex expressed interest to start PrEP. PrEP service could be an important community platform for chemsex intervention.