bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving grindability and bioaccessibility of chicken bone by in situ steam explosion
Authors: Kong Feng , Li Yue , Li Pengfei , Qiu Xinru , Guo Xingfeng , Chen Jinfa , Wang Wenhao 
Published: April 2023

SummaryThe impacts of in situ steam explosion (ISE) on the particle size, protein solubility and digestibility, calcium release and structural characteristics of chicken bone powder were analysed. ISE significantly reduced the average particle size from 142.62 to 84.47–105.10 μm, while maintained the proximate compositions. The Fourier transforms infrared spectra and X‐ray diffraction further illustrated that there were no marked differences in the functional groups between native and ISE bone powders. Moreover, soluble protein content in chicken bone powder was remarkably enhanced by the ISE from 3.28 to 3.73 mg g−1. ISE powder (at 121 °C for 90 min) had higher protein digestibility (48.63%) than that of native (30.82%). Finally, ISE powder showed a higher calcium release and 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulphonic acid) diammonium salt (ABTS) radical scavenging activity of digestive juice. The results proposed the feasibility of using ISE as an effective strategy to improve the nutritional quality of chicken bone.
Black garlic production: The influence of ageing temperature and duration on some physicochemical and antioxidant properties, and sugar content
Authors: Aoudeh Eyad , Oz Emel , Kelebek Hasim , Brennan Charles , Ahmad Naushad , Elobeid Tahra , Oz Fatih 
Published: April 2023

SummaryHerein, some quality characteristics (water content, pH, antioxidant activity and sugar contents) of fresh garlic (Taşköprü, Türkiye) and black garlic, which were produced under various ageing temperatures (60 °C, 70 °C and 80 °C) and durations (30, 45 and 60 days), and the effect of ageing processes on these quality characteristics were determined. The ageing process caused a reduction (P < 0.01) in the water content and pH value of the samples, while enhanced (P < 0.01) antioxidant activity and increased (P < 0.01) the content of glucose, fructose, sucrose and reducing sugar. Both the water content and pH value of the black garlic declined significantly with increasing ageing temperature, while only pH value of the black garlic declined significantly with increasing ageing duration. Ageing samples at 60 °C and 70 °C exhibited higher antioxidant activity than those aged at 80 °C, which had similar activity to the fresh samples. A similar status was observed when the ageing temperature was prolonged to 60 days. Sucrose concentration of the black garlic samples raised with elevating the ageing temperature and declined with prolonging the duration. While a remarkable decline in the reducing sugars of the black garlic samples was observed with elevating the ageing temperature, the maximum concentration was recorded on the 45th day of the ageing process. However, the black garlic samples produced at 60 °C for 60 days or 70 °C for 30 days could be recommended to get a final product with good antioxidant capacity, adequate amount of free sugars, pH value and water content.
Recent advances in ultrasound application in fermented and non‐fermented dairy products: antibacterial and bioactive properties
Authors: Kaveh Shima , Gholamhosseinpour Aliakbar , Hashemi Seyed Mohammad Bagher , Jafarpour Dornoush , Castagnini Juan M. , Phimolsiripol Yuthana , Barba Francisco J. 
Published: April 2023

SummaryUltrasound, as an innovative approach, is a suitable alternative for dairy heat processing and can effectively inactivate microorganisms. Its capacity in improving the bioactive and functional properties of fermented dairy products has been stated in several studies. Increase in the amplitude of ultrasound up to 60% provided significantly increase in peptide content. This review provides comprehensive information of ultrasound in the production of both fermented and non‐fermented dairy products. In‐depth discussion of the effect of ultrasound on the bioactive properties of dairy products, linking the anticancer, antioxidant, and anti‐inflammatory effects with the content of bioactive peptides, exopolysaccharides, and the activity of enzymes were also discussed. Ultrasound pre‐treatment induces proteolysis and production of bioactive compounds such as peptides and exopolysaccharides that are responsible for antibacterial and health beneficial properties of these products including antioxidants, anticancer, anti‐hypertensive, and anti‐diabetic activities. The application of ultrasound at optimum conditions is a promising way to produce functional fermented and non‐fermented dairy products with various health‐beneficial activities.
Predictors of anxiety among pregnant women with gestational diabetes mellitus and their partners: The mediating role of marital satisfaction
Authors: Han Rong‐rong , Xiang Zhi‐xuan , Zhang Shu‐han , Gao Ling‐ling 
Published: April 2023

AbstractAimsThis study aims to examine the prevalence of anxiety symptoms and identify predictors of anxiety among pregnant women with gestational diabetes mellitus and their partners and explore the mediating role of marital satisfaction between maternal and paternal anxiety.DesignA cross‐sectional study was conducted in Guangzhou, China, from July 2021 to May 2022.MethodsA total of 306 dyads of pregnant women with gestational diabetes mellitus and their partners completed the State–Trait Anxiety Inventory, Locke–Wallace Marital Adjustment Test and the socio‐demographic and clinical data sheet.ResultsThe prevalence of anxiety symptoms was 32.4% and 36.6% in pregnant women with gestational diabetes mellitus and their partners, respectively. The predictors of maternal anxiety were paternal anxiety, maternal marital satisfaction, maternal monthly salary, fasting glucose value and 1‐h glucose value. By contrast, the predictors of paternal anxiety were maternal anxiety, paternal marital satisfaction and paternal monthly salary. Moreover, the relationship between maternal and paternal anxiety was mediated by marital satisfaction.ConclusionsThe anxiety symptoms of pregnant women with gestational diabetes mellitus and their partners influence each other, and this relationship was mediated by marital satisfaction. Every couple should be screened for anxiety symptoms and treated as a team rather than focusing solely on the pregnant woman.
Gregory Palamas, Essence and Energy: Eradicating Falsehood and Establishing Truth
Authors: Weinandy Thomas G. 
Published: April 2023

AbstractThis essay examines Gregory Palamas's distinction between God's essence and his energies. His position has been controversial down to the present day – some scholars supporting his distinction and others severely criticizing it. I demonstrate that the distinction between God's essence and his energies is indeed fallacious – scripturally, philosophically, and theologically. I offer, in its place, a scriptural, philosophical, and theological position that not only adequately addresses Gregory's concerns, but also one that is true to who God is as a trinity of persons. My essay is divided into five sections. The first briefly provides the historical circumstances that prompted Gregory to defend the distinction between God's essence and his energies. Second, I present Palamas's arguments on behalf of his distinction between God's essence, the manner in which he exists in himself, and his uncreated energies, the manner in which he acts in relation to what is not God. Third, I critically examine the various interpretations offered by those who support Gregory's distinction, particularly Vladimir Lossky, John Meyendorff, Norman Russell, and A.N. Williams. Fourth, I offer my own critique of Palamas's position. Finally, I propose an alternative understanding of the issues involved, an interpretation that addresses Gregory's concerns. In so doing, I will conceive and articulate a position that is more faithful to biblical revelation, the conciliar magisterial tradition, and one that is more philosophically and theologically coherent.
Migration information campaigns: How to analyse their impact?
Authors: Cham Omar N. , Trauner Florian 
Published: April 2023

AbstractInformation campaigns aim at discouraging potential migrants from leaving their countries irregularly. This article discusses how to analyse the impact of such campaigns by identifying different research lines in the literature. The impact of migration information campaigns may be explored by, firstly, focusing on transnational migratory data and inter‐state relations (the macro‐level); secondly, by investigating their impact on narratives within societies (the meso‐level); and, finally, by investigating the micro‐level of their influence on migratory decision‐making. At each level, scholars face considerable methodological challenges to filter out the impact of campaigns. This article suggests that a promising research avenue is to analyse more widely the narratives and information sources upon which (potential) migrants rely. Opening up the research focus may avoid the risk of over‐emphasising the impact of information campaigns by only looking at them. It allows to better understand which sources of information actually influence migratory behaviour.
Integer programming formulations for the k$k$‐in‐a‐tree problem in graphs
Authors: Ferreira Lucas Saldanha , Santos Vinicius Fernandes dos , Valle Cristiano Arbex 
Published: April 2023

AbstractChudnovsky and Seymour proposed the Three‐in‐a‐tree algorithm which solves the following problem in polynomial time: given three fixed vertices in a simple finite graph, check whether an induced tree containing these vertices exists. In this paper, we deal with a generalization of this problem, referred to henceforth as ‐in‐a‐tree. The ‐in‐a‐tree checks whether a graph contains an induced tree spanning given vertices. When is part of the input, the problem is known to be NP‐complete. If is a fixed given number, its complexity is an open question, although there are efficient algorithms for restricted cases such as claw‐free graphs, graphs with a girth of at least and chordal graphs. We present mixed‐integer programming formulations for this problem, and we show that instances with up to 25,000 vertices can be solved in reasonable computational time.
Down‐regulation of human long non‐coding RNA LINC01187 is associated with nephropathies
Authors: Manolakou Theodora , Kaltezioti Valeria , Prakoura Niki , Kavvadas Panagiotis , Reichelt‐Wurm Simone , Gakiopoulou Harikleia , Banas Miriam , Banas Bernhard , Lindenmeyer Maja T. , Cohen Clemens D. , Boor Peter , Djudjaj Sonja , Boumpas Dimitrios T. , Chatziantoniou Christos , Charonis Aristidis , Politis Panagiotis K. 
Published: April 2023

AbstractChronic kidney diseases affect a substantial percentage of the adult population worldwide. This observation emphasizes the need for novel insights into the molecular mechanisms that control the onset and progression of renal diseases. Recent advances in genomics have uncovered a previously unanticipated link between the non‐coding genome and human kidney diseases. Here we screened and analysed long non‐coding RNAs (lncRNAs) previously identified in mouse kidneys by genome‐wide transcriptomic analysis, for conservation in humans and differential expression in renal tissue from healthy and diseased individuals. Our data suggest that LINC01187 is strongly down‐regulated in human kidney tissues of patients with diabetic nephropathy and rapidly progressive glomerulonephritis, as well as in murine models of kidney diseases, including unilateral ureteral obstruction, nephrotoxic serum‐induced glomerulonephritis and ischemia/reperfusion. Interestingly, LINC01187 overexpression in human kidney cells in vitro inhibits cell death indicating an anti‐apoptotic function. Collectively, these data suggest a negative association of LINC01187 expression with renal diseases implying a potential protective role.
Morphology of proximal and distal human semitendinosus compartments and the effects of distal tendon harvesting for anterior cruciate ligament reconstruction
Authors: Kositsky Adam , Maas Huub , Barrett Rod S. , Kennedy Ben , Stenroth Lauri , Korhonen Rami K. , Vertullo Christopher J. , Diamond Laura E. , Saxby David J. 
Published: April 2023

AbstractThe human semitendinosus muscle is characterized by a tendinous inscription separating proximal and distal neuromuscular compartments. As each compartment is innervated by separate nerve branches, potential exists for independent operation and control of compartments. However, the morphology and function of each compartment have not been thoroughly examined in an adult human population. Further, the distal semitendinosus tendon is typically harvested for use in anterior cruciate ligament reconstruction surgery, which induces long‐term morphological changes to the semitendinosus muscle‐tendon unit. It remains unknown if muscle morphological alterations following anterior cruciate ligament reconstruction are uniform between proximal and distal semitendinosus compartments. Here, we performed magnetic resonance imaging on 10 individuals who had undergone anterior cruciate ligament reconstruction involving an ipsilateral distal semitendinosus tendon graft 14 ± 4 months prior, extracting morphological parameters of the whole semitendinosus muscle and each individual compartment from both the (non‐injured) contralateral and surgical legs. In the contralateral leg, volume and length of the proximal compartment were smaller than the distal compartment. No between‐compartment differences in volume or length were found for anterior cruciate ligament reconstructed legs, likely due to greater shortening of the distal compared to the proximal compartment after anterior cruciate ligament reconstruction. The maximal anatomical cross‐sectional area of both compartments was substantially smaller on the anterior cruciate ligament reconstructed leg but did not differ between compartments on either leg. The absolute and relative between‐leg differences in proximal compartment morphology on the anterior cruciate ligament reconstructed leg were strongly correlated with the corresponding between‐leg differences in distal compartment morphological parameters. Specifically, greater between‐leg morphological differences in one compartment were highly correlated with large between‐leg differences in the other compartment, and vice versa for smaller differences. These relationships indicate that despite the heterogeneity in compartment length and volume, compartment atrophy is not independent or random. Further, the tendinous inscription endpoints were generally positioned at the same proximodistal level as the compartment maximal anatomical cross‐sectional areas, providing a wide area over which the tendinous inscription could mechanically interact with compartments. Overall, results suggest the two human semitendinosus compartments are not mechanically independent.
A proteomics study to explore differential proteins associated with the pathogenesis of ameloblastoma
Authors: Cui Yunyi , Li Hexiang , Xiao Tiepeng , Zhang Xudong , Hou Yali , Li Haiyang , Li Xiangjun 
Published: April 2023

AbstractBackgroundReports on the proteomic studies of ameloblastoma and other common odontogenic lesions are limited. We thus explored the differential proteins among ameloblastoma, odontogenic keratocyst, dentigerous cyst, and normal gingival tissue using proteomics and identified hub proteins involved in the local aggressiveness and recurrence of ameloblastoma.MethodsSamples were obtained from 14 patients with ameloblastoma, 6 with odontogenic keratocyst, 9 with a dentigerous cyst, and 5 with normal gingival tissue. Proteins were then extracted, purified, quantified, and analysed using Easy‐nLC chromatography and mass spectrometry. Further functional annotation and enrichment analyses were performed using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes on the target protein collection. Protein clustering and protein–protein interaction network analyses were used to screen the hub proteins. Proteins with significant interactions were screened according to their degree index. These results were verified by immunohistochemical staining. Proteins meeting the screening criteria of expression difference ploidy >1.2‐fold (upregulation and downregulation) andp < 0.05 were considered differential proteins.ResultsIn ameloblastoma, 808 differential proteins were upregulated and 505 were downregulated compared with those in odontogenic keratocyst; 309 were upregulated and 453 were downregulated compared with those in dentigerous cyst; and 2210 were upregulated and 829 were downregulated compared with those in normal gingival tissue. The three groups of differential proteins were associated with cellular exosomes, antigen binding, complement activation, human papillomavirus infection, focal adhesion, cell adhesion molecules, and metabolic pathways.ConclusionCDH3 is associated with the local aggressiveness and recurrence of ameloblastoma and is a potential therapeutic target.
MicroRNA‐27a inhibits porcine type I muscle fibre gene expression by directly targeting peroxisome proliferator‐activated receptor‐γ coactivator‐1α
Authors: Wang Weiwei , Yu Qinping , Cao Qingyun , Ye Hui , Zhang Changming , Dong Zemin , Feng Dingyuan , Zuo Jianjun 
Published: April 2023

AbstractMicroRNAs are one of the key determinants of muscle fibre development and phenotype in mammals. The preliminary experiment implied that microRNA‐27a (miR‐27a) might involve in regulation of muscle fibre type composition of pigs. Thereby, the present study aimed to confirm the regulatory effect of miR‐27a on porcine type I muscle fibre‐encoding gene (myosin heavy chain gene 7, MYH7) expression and its related mechanism. We firstly observed opposite expression patterns between miR‐27a and MYH7 as well as between miR‐27a and peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α) during differentiation of porcine skeletal muscle satellite cells. Through the subsequent transfection analysis in porcine myotubes, we found that miR‐27a suppressed the expression of MYH7 and PGC‐1α. Besides, miR‐27a induced inhibition of PGC‐1α downstream targets, namely myocyte enhancer factor‐2C (MEF2C) along with mitochondrial biogenesis and oxidative metabolism‐related factors such as nuclear respiratory factor 1 (NRF‐1), mitochondrial transcription factor A (mtTFA), cytochrome c (Cytc) and cytochrome oxidase IV (COX Ⅳ) and succinodehydrogenase (SDH). Dual‐luciferase reporter analysis revealed that miR‐27a could bind to the predicted target site in the 3ʹ‐untranslated regions of PGC‐1α mRNA, confirming a direct targeting of PGC‐1α by miR‐27a. Moreover, PGC‐1α silencing abolished the promotive effects of miR‐27a inhibitor on MYH7, PGC‐1α and its downstream targets (MEF2C, NRF‐1, mtTFA, COX Ⅳ, Cytc and SDH) in porcine myotubes. Collectively, miR‐27a inhibits porcine MYH7 expression by negatively regulating PGC‐1α and PGC‐1α‐controlled MEF2C expression as well as mitochondrial biogenesis and oxidative metabolism. Our findings may provide a molecular target for genetic or nutritional control of muscle fibre phenotype of pigs, probably having an important implication for regulating pork quality.
Gender differences of authors of major Hepatology society guidelines during the past 15 years
Authors: Tang Xiaowei , Luo Bei , Huang Shu , Jiang Jiao , Chen Yuan , Shi Xiaomin , Zhang Wei , Shi Lei , Zhong Xiaolin , Lü Muhan 
Published: April 2023

AbstractBackground and ObjectiveRecent studies have shown that women are underrepresented as authors of medical research and clinical practice guidelines. This study aimed to evaluate gender disparities of authors of major hepatology guidelines.MethodsWe reviewed the hepatology guidelines published by the following major gastroenterology societies from January 2008 to September 2022: the American Gastroenterological Association (AGA), American College of Gastroenterology (ACG), American Association for the Study of Liver Diseases (AASLD), Asian‐Pacific Association for the Study of the Liver (APASL), British Society of Gastroenterology (BSG), European Association for the Study of the Liver (EASL) and Korean Association for the Study of the Liver (KASL). We determined the topic and the gender of all authors of each guideline. The numbers of men authors, women authors and total authors were collected. The trends of women first authors, women senior authors and total women authors were assessed. A logistic regression analysis was performed to analyse the relationship between the gender of the first or senior author and related factors.ResultsWe identified 103 hepatology guidelines published between January 2008 and September 2022 published by the AGA, ACG, AASLD, APASL, BSG, EASL, and KASL. The gender of 1096 of 1100 (99.6%) authors was determined. Therefore, a total of 1096 authors were included: 223 (20.3%) authors were women and 873 (79.7%) authors were men. Women comprised 14.6% of all first authors, and 20.4% of all senior authors were women. Only the AASLD had writing committees comprising more than 30% total women authors. The proportions of women senior authors and total women authors increased significantly during the study period (p < .05). Women first authors and women senior authors were more likely to publish guidelines with more women authors. Women first authors were less likely to be co‐authors with men authors.ConclusionsOver the course of the past decade, the proportion of women authors of major hepatology guidelines has been low; however, this gender gap appears to be closing.
Thematic Units and Developments. On the Persistence of ‘Organic Form’ in Chamber Music Between 1910 and 1930
Authors: Borio Gianmario 
Published: April 2023

ABSTRACTTheFormenlehre(theory of the musical form), inaugurated by Adolf Bernhard Marx after Beethoven's death and witnessed by several treatises at the end of the nineteenth and the beginning of the twentieth centuries, has left traces in the writings and works of Béla Bartók, Alban Berg, Paul Hindemith, Arnold Schoenberg and Anton Webern. Chamber music (especially string quartets) is the area in which the dialogue with the past is most tangible. The adoption of traditional concepts is associated with significant changes of thematic structures and developmental techniques. Thus, the transformations of the harmonic thinking are paralleled by the way the composers dealt with phrase organisation and syntactic functions.
A case of adult‐onset diffuse midline glioma diagnosed by histone H3K27M immunostaining after death, which required differentiation from brainstem encephalitis and myelitis
Authors: Togawa Natsuko , Mitsuhashi Masahiro , Yamashita Hirofumi , Minamiguchi Sachiko , Arakawa Yoshiki , Ayaki Takashi , Kuzuya Akira , Ikeda Akio , Takahashi Ryosuke 
Published: April 2023

AbstractH3K27M‐mutant diffuse midline glioma is a malignant glioma that was newly added to the World Health Organization classification in 2016. In diffuse midline glioma, the H3K27M‐mutant sometimes develops sub‐acutely and requires a differential diagnosis from encephalomyelitis. Here, we report a case of adult‐onset diffuse midline glioma that was diagnosed by immunostaining for histone H3K27M after death. The present case required a differential diagnosis of autoimmune cervical myelitis and brainstem encephalitis.