bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards automated risk prediction of persistent pain: Exploring psychosocial factors from electronic health records after breast cancer surgery
Authors: Liukas Tanja , Rosio Riitta , Peltonen Laura‐Maria 
Published: January 2023

AbstractAimThe aim of this study was to describe what psychosocial factors associated with postoperative persistent pain can be found in electronic health records of patients with breast cancer, and which of these factors that may be used in the development of a decision‐support system algorithm to better support health professionals in their clinical work.DesignA qualitative descriptive study.MethodsA retrospective electronic health record review was done using manual semantic annotation. A set of 101 records of patients with breast cancer were selected by computerized random sampling. The data were analysed with deductive content analysis.ResultsA total of 337 different expressions describing psychosocial factors associated with postoperative persistent pain were identified from the documentation done in the electronic health records. These regarded psychological strength and resilience, social factors, emotional factors, anxiety, sleep‐related factors and depression. No records were found dealing with pain catastrophizing. Although psychosocial factors associated with postoperative persistent pain were documented in the electronic health records, documentation about such factors was not found in all patient's records, nor was the documentation done in a systematic manner.ConclusionsThe findings show that there is potential to use electronic health records as information source in the development of decision‐support system algorithms to better support nurses in the identification of patients at risk of developing postoperative persistent pain. However, the documentation quality needs to be acknowledged in the application of decision support systems, which are built on information extracted from electronic health records. Future work is needed to standardize documentation practices and assess the comprehensiveness of the documentation.
Association between health‐related quality of life and nonadherence to antihypertensive medication
Authors: Kim Ka Young 
Published: January 2023

AbstractAimWe aimed to examine the association between nonadherence to antihypertensive medications and Health‐related quality of life.DesignA cross‐sectional survey was undertaken.MethodsThis study was conducted using the data from the Korea National Health and Nutrition Examination Survey. A total of 6493 participants who diagnosed with hypertension, affected by hypertension at the time of survey, and took daily antihypertensive medications or never took this medication were included. Multiple logistic regression analysis was performed to determine the factors that influenced the patients' nonadherence to antihypertensive medications according to sex.ResultsOur results showed that anxiety/depression was positively associated with antihypertensive medication nonadherence, regardless of sex. According to sex, mobility was negatively associated with antihypertensive medication nonadherence in women. In men, living together was negatively related to antihypertensive medication nonadherence. This study showed the factors associated with antihypertensive medication nonadherence according to sex. HRQoL was associated with antihypertensive medication nonadherence.
Fourier spectral methods with exponential time differencing for space‐fractional partial differential equations in population dynamics
Authors: Harris Ashlin Powell , Biala Toheeb A. , Khaliq Abdul Q. M. 
Published: January 2023

AbstractPhysical laws governing population dynamics are generally expressed as differential equations. Research in recent decades has incorporated fractional‐order (non‐integer) derivatives into differential models of natural phenomena, such as reaction–diffusion systems. In this paper, we develop a method to numerically solve a multi‐component and multi‐dimensional space‐fractional system. For space discretization, we apply a Fourier spectral method that is suited for multidimensional partial differential equation systems. Efficient approximation of time‐stepping is accomplished with a locally one dimensional exponential time differencing approach. We show the effect of different fractional parameters on growth models and consider the convergence, stability, and uniqueness of solutions, as well as the biological interpretation of parameters and boundary conditions.
Spontaneous pneumorrhachis with pneumomediastinum, scrotal emphysema, and extensive subcutaneous emphysema in a patient with pneumonia: A case report and literature review
Authors: Zhuang Yuan , Zou Jia lin , Huang Yu fu , Hu Dong xu , Shen Xing , Mao Xiao yan 
Published: January 2023

AbstractBackgroundSpontaneous pneumorrhachis with pneumomediastinum, scrotal emphysema, and extensive subcutaneous emphysema caused by acute pneumonia are rarely observed in clinical practice.Case PresentationHerein, we report a case of a 12‐year‐old boy with spontaneous pneumorrhachis with pneumomediastinum, scrotal emphysema, and extensive subcutaneous emphysema caused by a severe cough due to mycoplasma pneumonia. This patient neither received invasive or noninvasive ventilator treatment nor surgical treatment before the onset of the disease. After treatment, the patient recovered smoothly and was discharged from the hospital.Literature ReviewWe reviewed all cases of spontaneous pneumorrhachis in children and adolescents between 1988 and 2022 in the PubMed database. Twenty‐seven cases met our inclusion criteria, and the data on demographic information, triggers, comorbidities, symptoms, imaging findings, treatment, and prognosis were extracted and analyzed.ConclusionAlthough spontaneous pneumorrhachis is a rare condition, it has been reported in children. Computed tomography scanning is the gold standard for its detection. Spontaneous pneumorrhachis is typically a benign disease. This condition usually does not require any special treatment and should be monitored as common types of air leaks, such as pneumothorax and pneumomediastinum.
Transcriptomic profiling and genomic rearrangement landscape of Nigerian prostate cancer
Authors: Mavura Yusuph , Song Hanbing , Xie Jamie , Tamayo Pablo , Mohammed Abdullahi , Lawal Ahmad T. , Bello Ahmad , Ibrahim Sani , Faruk Mohammed , Huang Franklin W. 
Published: January 2023

AbstractBackgroundMen of African ancestry have disproportionately high incidence rates of prostate cancer (PCa) and have high mortality rates. While there is evidence for a higher genetic predisposition for incidence of PCa in men of African ancestry compared to men of European ancestry, there have been few transcriptomic studies on PCa in men of African ancestry in the African continent.ObjectiveWe performed transcriptomic profiling and fusion analysis on bulk RNA sequencing (RNA‐seq) samples from 24 Nigerian PCa patients to investigate the transcriptomic and genomic rearrangement landscape of PCa in Nigerian men.DesignBulk RNA‐seq was performed on 24 formalin‐fixed paraffin‐embeded (FFPE) prostatectomy specimens of Nigerian men. Transcriptomic analysis was performed on 11 high‐quality samples. Arriba Fusion and STAR Fusion were used for fusion detection.Results4/11 (36%) of the samples harbored an erythroblast transformation‐specific (ETS) fusion event; 1/11 (9%) had a TMPRSS2‐ERG fusion; 2/11 had a TMPRSS2‐ETV5 fusion, and 1/11 had a SLC45A3‐SKIL fusion. Hierarchical clustering of normalized and mean‐centered gene expression showed clustering of fusion positive samples. Furthermore, we developed gene set signatures for Nigerian PCa based on fusion events. By projecting the cancer genome atlas prostate adenocarcinoma (TCGA‐PRAD) bulk RNA‐seq data set onto the transcriptional space defined by these signatures derived from Nigerian PCa patients, we identified a positive correlation between the Nigerian fusion signature and fusion positive samples in the TCGA‐PRAD data set.ConclusionsLess frequent ETS fusion events other than TMPRSS2‐ERG such as TMPRSS2‐ETV5 and non‐ETS fusion events such as SLC45A3‐SKIL may be more common in PCa in Nigerian men. This study provides useful working transcriptomic signatures that characterize oncogenic states representative of specific gene fusion events in PCa from Nigerian men.
Decursin inhibits EGFR‐ERK1/2 signaling axis in advanced human prostate carcinoma cells
Authors: Bhat Tariq A. , Dheeraj Arpit , Nambiar Dhanya K. , Singh Surya Pratap , Yim Dong Sool , Singh Rana P. 
Published: January 2023

AbstractWe have shown that decursin, a coumarin compound, induces cell cycle arrest and apoptosis in human prostate cancer cells (PCa); however, its molecular mechanisms are largely unexplored. We studied the mechanisms associated with its anticancer activity in advanced human prostate carcinoma cells. We found that decursin inhibited epidermal growth factor receptor (EGFR) signaling by inhibiting its activating phosphorylation at tyrosine 1068 residue in DU145 and 22Rv1 cells. This inhibition of EGFR was associated with the downregulation of ERK1/2 phosphorylation. Both EGFR and ERK1/2 are known to be deregulated/activated in many human malignancies. Consistent with our earlier study, decursin (25–100 µM) treatment for 24–72 h inhibited DU145 cell proliferation by 49%–87% (p < 0.001) which was associated with strong G1 phase arrest and cell death. It also decreased (p < 0.001) the number of surviving colonies. Decursin moderately increased the expression of Rb‐related proteins p107 and p130 but decreased the levels of E2F family transcription factors including E2F‐3, E2F‐4 and E2F‐5. Further, decursin strongly inhibited the growth of androgen–dependent prostate carcinoma 22Rv1 cells from 61% to 79% (p < 0.001) and arrested these cells at G1 phase via induction of cyclin‐dependent kinase inhibitor p27/Kip1 and downregulation of CDK2 and CDK4 protein expression. Additionally, EGFR inhibitor erlotinib‐ and EGF ligand‐modulated EGFR activation validated EGFR signaling as a target of decursin‐mediated cell growth inhibition and cytotoxicity. Decursin decreased EGF ligand‐induced phosphorylation of EGFR (Y‐1068) as well as activation of its downstream mediator, ERK1/2. Furthermore, inhibitory targeting of EGFR‐ERK1/2 axis by combinatorial treatment of decursin and erlotinib further sensitized DU145 cells for the decursin‐induced growth inhibition and cell death. Overall, these findings strongly suggest that anticancer efficacy of decursin against human PCa involves inhibitory targeting of EGFR‐ERK1/2 signaling axis, a pathway constitutively active in advanced PCa.
Determination of elemental impurities in lomefloxacin hydrochloride ear drops by inductively coupled plasma‐mass spectrometry using oxygen reaction mode and study of their catalytic effect on photodegradation reaction
Authors: Xu Bingyong , Gao Jiarui , Li Ping , Zeng Hongxia , Su Weike , Wang Jian 
Published: January 2023

RationaleThis study developed a method for the simultaneous determination of 12 element impurities in lomefloxacin hydrochloride ear drops using inductively coupled plasma‐mass spectrometry (ICP‐MS) in accordance with the requirements of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Q3D. However, this product contains high concentrations of organic compounds such as glycerol and ethanol, and soluble carbon interference exists when it is determined by direct injection method. Therefore, we applied ICP‐MS using oxygen reaction mode to reduce the effect of high organic matter on plasma body. The catalytic effect of trace metal ions on the photodegradation of lomefloxacin hydrochloride was also investigated.MethodsThe sample was dissolved, diluted, and directly determined by direct injection using oxygen reaction mode of ICP‐MS with 45Sc, 73Ge, and 115In as internal standards. Direct injection using oxygen reaction mode was equipped with argon–oxygen mixer. To investigate the catalytic effect of metal ions on photodegradation, a series of combinations of lomefloxacin hydrochloride mixed with different metal ions were designed. After being irradiated under ultraviolet light for 10 days, the photodegraded impurities in combinations were determined using high‐performance liquid chromatography.ResultsThe linear relationships in the corresponding concentration range for 12 element impurities were good (r > 0.9993). Limits of detection were between 0.002 and 1.294 ng ml−1. The average recoveries were 93.7%–108.2%, and the precision relative standard deviation was 0.04%–0.55% (n = 6). The experimental results showed that metal ions had a certain catalytic effect on photodegradation of lomefloxacin when EDTA, Mg2+, and Cu2+ coexisted.ConclusionsICP‐MS using oxygen reaction mode is suitable for the direct determination of the sample rich in organic matter without digestion and can effectively eliminate the interference of high organic matter in this product. The established method was rapid, sensitive, and accurate and can be used for the quality control of elemental impurities in lomefloxacin hydrochloride ear drops.
Sphingosine‐1‐phosphate related signalling pathways manipulating virus replication
Authors: Zhang Lu , Liu Juan , Xiao Erya , Han Qingzhen , Wang Lin 
Published: January 2023

AbstractViruses can create a unique cellular environment that facilitates replication and transmission. Sphingosine kinases (SphKs) produce sphingosine‐1‐phosphate (S1P), a bioactive sphingolipid molecule that performs both physiological and pathological effects primarily by activating a subgroup of the endothelial differentiation gene family of G‐protein coupled cell surface receptors known as S1P receptors (S1PR1‐5). A growing body of evidence indicates that the SphK/S1P axis is crucial for regulating cellular activities in virus infections like respiratory viruses, enteroviruses, hepatitis viruses, herpes viruses, and arboviruses replicate. Depending on the type of virus, pro‐ or anti‐viral activities of the SphK/S1P axis sometimes rely on the host immune system and sometimes directly through intracellular signalling pathways or cell proliferation. Recent research has shown novel roles of S1P and SphK in viral replication. Sphingosine kinase isoforms (SphK1 and SphK2) levels can be manipulated by several viruses to promote the effects that are expected. Regulation of cellular signalling pathways plays a significant role in the mechanism. The purpose of this review is to provide insight of the characters played by the SphK/S1P axis throughout diverse viral infection processes. We then assess potential therapeutic methods that are based on S1P signalling and metabolism during viral infections.
Fractional‐order fault‐tolerant containment control of multiple fixed‐wing UAVs via disturbance observer and interval type‐2 fuzzy neural network
Authors: Yu Ziquan , Xu Yiwei , Zhang Youmin , Jiang Bin , Su Chun‐Yi 
Published: January 2023

AbstractThis article investigates the fault‐tolerant containment control (FTCC) problem for a group of fixed‐wing unmanned aerial vehicles with simultaneous considerations of faults and collision avoidance. A fractional‐order (FO) FTCC scheme is established to steer all follower UAVs into the convex hull formed by the leader UAVs with the involvements of FO calculus, disturbance observers (DOs), and interval type‐2 fuzzy neural networks (IT2FNNs). In the proposed control protocol, FO sliding‐mode surfaces with artificial potential functions are first designed to revamp the filtered containment errors. Then, the DOs with FO calculus are constructed to estimate the FO lumped disturbances due to faults and external disturbances. Moreover, to compensate for the DO estimation errors, IT2FNN learning mechanisms are introduced to improve the FTCC capability. It is shown by Lyapunov stability analysis that all follower UAVs can successfully converge into the convex hull spanned by the leader UAVs without collisions even when a portion of UAVs is encountered by faults. Simulation results are presented to show the effectiveness of the developed control scheme.
A cloud's silver lining? The impact of policy interventions on new and maturing technology ventures' online recruitment
Authors: Lucas David S. , Bellavitis Cristiano , Park U. David 
Published: January 2023

AbstractResearch summaryWe synthesize the external enablement (EE) framework with insights from labor economics and strategic human capital to theorize how restrictive policy interventions shape technology ventures' employee recruitment, attending to both sides of the hiring dyad. We engage in a quantitative study of over 220,000 recruiting interactions between technology ventures and candidates on a prominent digital networking platform surrounding the early COVID‐19 pandemic policy responses. We find that firms' recruitment declined significantly while candidates' responsiveness increased during the early COVID‐19 policy interventions. In turn, young technology ventures were enabled to hire more during the interventions, whereas maturing ventures were enabled to hire differently—acquiring candidates with greater entrepreneurial orientation. Our work extends the EE framework to human resource strategies and to heterogeneous enablement across firm age.Managerial summaryHiring is a critical task for young and maturing venture firms, and environmental disruptions can impinge heavily on recruiting processes. We study how restrictive policy interventions shape technology ventures' employee recruitment. Examining over 220,000 recruiting interactions on a major digital platform before and during the early COVID‐19 policy responses, we find that restrictive policy interventions alter the technology venture labor market, deterring some firms from recruiting while making others more successful in their continued hiring efforts. Furthermore, we discover that maturing firms are more adaptive than young firms in their selection of candidates during policy interventions—seeking employees with more entrepreneurial characteristics.
Blowing‐Combustion Synthesis of Sponge‐like NixZn1−xFe2O4 and Its Structural and Magnetic Properties
Authors: Chen Chuan , Yao Tianhao , Qian Sen , Zhang Qiang , Zhang Ximin 
Published: January 2023

AbstractSpinel ferrites have been widely used in various fields, among which nickel‐zinc (NiZn) ferrites have drawn much attention due to their high electrical resistivity as well as low eddy current loss. To accommodate highly‐integrated modern electronic devices, the preparation methods for nano/micro‐sized NiZn ferrites have been widely discussed. Nevertheless, these current synthesis routes are usually cost/time‐consuming, which hinders their large‐scale production for practical applications. Herein, we present a facile, low‐cost synthesis strategy for NiZn ferrites (NixZn1−xFe2O4, x=0, 0.25, 0.5, 0.75 and 1) through a blowing‐combustion method. The effect of Ni/Zn molar concentration on the structure, morphology as well as magnetic properties has been thoroughly investigated through X‐ray diffraction, Raman spectroscopy, scanning electron microscopy and vibrating sample magnetometer. Thanks to the synergetic effect of the pure phase and moderate Ni molar concentration, the Ni0.75Zn0.25Fe2O4 shows an enhanced saturation magnetization of 44.98 emu/g. More importantly, this blowing‐combustion method may also be commonly applied to other spinel ferrites with different stoichiometric ratios and heteroatom doping.
Conductive Polymer‐Coated 3D Printed Microneedles: Biocompatible Platforms for Minimally Invasive Biosensing Interfaces
Authors: Keirouz Antonios , Mustafa Yasemin L. , Turner Joseph G. , Lay Emily , Jungwirth Ute , Marken Frank , Leese Hannah S. 
Published: January 2023

AbstractConductive polymeric microneedle (MN) arrays as biointerface materials show promise for the minimally invasive monitoring of analytes in biodevices and wearables. There is increasing interest in microneedles as electrodes for biosensing, but efforts have been limited to metallic substrates, which lack biological stability and are associated with high manufacturing costs and laborious fabrication methods, which create translational barriers. In this work, additive manufacturing, which provides the user with design flexibility and upscale manufacturing, is employed to fabricate acrylic‐based microneedle devices. These microneedle devices are used as platforms to produce intrinsically‐conductive, polymer‐based surfaces based on polypyrrole (PPy) and poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS). These entirely polymer‐based solid microneedle arrays act as dry conductive electrodes while omitting the requirement of a metallic seed layer. Two distinct coating methods of 3D‐printed solid microneedles, in situ polymerization and drop casting, enable conductive functionality. The microneedle arrays penetrate ex vivo porcine skin grafts without compromising conductivity or microneedle morphology and demonstrate coating durability over multiple penetration cycles. The non‐cytotoxic nature of the conductive microneedles is evaluated using human fibroblast cells. The proposed fabrication strategy offers a compelling approach to manufacturing polymer‐based conductive microneedle surfaces that can be further exploited as platforms for biosensing.
A review study on unmanned aerial vehicle and mobile robot technologies on damage inspection of reinforced concrete structures
Authors: Wang Jiehui , Ueda Tamon 
Published: January 2023

AbstractFor damaged buildings that had suffered from a destructive earthquake, timely damage inspection is essential to evaluate their residual seismic safety as well as to assess the long‐term maintenance capacity for planning a suitable structural rehabilitation strategy for further service. However, the conventional inspection method by human hands is time‐consuming, highly costly, and risky for inspectors in the fieldwork. Thus, in this present study, the current situation for structural damage inspection is summarized, the future potentials of newly developed technology in this field are explored, and the application and usage of robotic technologies with unmanned aerial vehicles (UAVs) and mobile robots that are rapidly developed recently have been reviewed and evaluated. In this work an overview is given of the practical applications of the UAV‐ and mobile robot‐based damage inspection, in which these robotic machines are employed as useful tools to inspect and monitor the damaged condition of infrastructure facilities or buildings by collecting photography data. In addition, a conceptual comparison with the conventional approach is given to allow a better understanding of the advantages and limitations of a robotic technology‐aimed damage inspection approach. Also, a discussion on instructions, recommendations, existing challenges, and future directions to address the robotic technology‐aimed damage inspection approach into further practice is presented.