bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival
Authors: Adey Brett N. , Cooper-Knock Johnathan , Al Khleifat Ahmad , Fogh Isabella , van Damme Philip , Corcia Philippe , Couratier Philippe , Hardiman Orla , McLaughlin Russell , Gotkine Marc , Drory Vivian , Silani Vincenzo , Ticozzi Nicola , Veldink Jan H. , van den Berg Leonard H. , de Carvalho Mamede , Pinto Susana , Mora Pardina Jesus S. , Povedano Panades Mónica , Andersen Peter M. , Weber Markus , Başak Nazli A. , Shaw Christopher E. , Shaw Pamela J. , Morrison Karen E. , Landers John E. , Glass Jonathan D. , Vourc’h Patrick , Dobson Richard J. B. , Breen Gerome , Al-Chalabi Ammar , Jones Ashley R. , Iacoangeli Alfredo 
Published: March 2023

Introduction: Caveolin-1 and Caveolin-2 (CAV1 and CAV2) are proteins associated with intercellular neurotrophic signalling. There is converging evidence that CAV1 and CAV2 (CAV1/2) genes have a role in amyotrophic lateral sclerosis (ALS). Disease-associated variants have been identified within CAV1/2 enhancers, which reduce gene expression and lead to disruption of membrane lipid rafts.Methods: Using large ALS whole-genome sequencing and post-mortem RNA sequencing datasets (5,987 and 365 tissue samples, respectively), and iPSC-derived motor neurons from 55 individuals, we investigated the role of CAV1/2 expression and enhancer variants in the ALS phenotype.Results: We report a differential expression analysis between ALS cases and controls for CAV1 and CAV2 genes across various post-mortem brain tissues and three independent datasets. CAV1 and CAV2 expression was consistently higher in ALS patients compared to controls, with significant results across the primary motor cortex, lateral motor cortex, and cerebellum. We also identify increased survival among carriers of CAV1/2 enhancer mutations compared to non-carriers within Project MinE and slower progression as measured by the ALSFRS. Carriers showed a median increase in survival of 345 days.Discussion: These results add to an increasing body of evidence linking CAV1 and CAV2 genes to ALS. We propose that carriers of CAV1/2 enhancer mutations may be conceptualised as an ALS subtype who present a less severe ALS phenotype with a longer survival duration and slower progression. Upregulation of CAV1/2 genes in ALS cases may indicate a causal pathway or a compensatory mechanism. Given prior research supporting the beneficial role of CAV1/2 expression in ALS patients, we consider a compensatory mechanism to better fit the available evidence, although further investigation into the biological pathways associated with CAV1/2 is needed to support this conclusion.
Nasal-temporal asymmetric changes in retinal peripheral refractive error in myopic adolescents induced by overnight orthokeratology lenses
Authors: Chen Xiaohang , Xiong Yan , Qi Xinzhou , Liu Longqian 
Published: March 2023

ObjectiveTo observe the changes in peripheral refraction in myopic adolescents after overnight orthokeratology and its influencing factors.MethodsThis was a prospective study among young myopic adolescents aged 8–14 years (n = 21). The peripheral refraction of the subjects was measured at 5, 10, 15, 20, 25, and 30° from the nasal and temporal side to the central fixation by WAM-5500 Open-field refractometer. The axial length, baseline spherical equivalent refraction, and other parameters were measured. The data were measured at baseline and 1, 3, and 12 months after wearing orthokeratology lenses.ResultsThe relative peripheral refraction at the nasal and temporal side from central to 30° eccentricity revealed relative hyperopic defocus in all subjects at baseline measurement. One month after wearing the orthokeratology lenses, the relative peripheral refraction changed to myopic defocus, the nasal-temporal relative peripheral refraction was asymmetric, and the observed difference was statistically significant. Positive correlations were found between the change amount of nasal relative peripheral refraction and baseline spherical equivalent refraction, the baseline nasal relative peripheral refraction was higher than that on the temporal side, and after orthokeratology, the value of nasal relative peripheral refraction was lower than that on the temporal side. The changes at 30° on both sides were correlated to the axial elongation (rNasal = 0.565, rTemporal = 0.526, p &lt; 0.05).ConclusionThis study demonstrated that after orthokeratology, relative peripheral hyperopia in the myopic patients turned into relative peripheral myopia, and the nasal-temporal asymmetry changed significantly after orthokeratology, which was correlated with the baseline refractive state.
Potential predictors for progression of moyamoya disease: A systematic review and meta-analysis
Authors: Cao Jun , Xing Zixuan , Dai Ling , Wang Tao , Zhang Yuhai , Feng Yao , Chen Yanfei 
Published: March 2023

BackgroundThe progress of Moyamoya disease (MMD) is often accompanied by the occurrence of new ischemia or hemorrhagic events, which was difficult to predict. This systematic review and meta-analysis aimed to identify predictors for progression in MMD patients.MethodsWe searched PubMed, Web of Science, Cochrane Library, and Embase databases up to December 10th, 2022 for randomized controlled trials, case-control studies, or cohort studies reporting predictors of disease progression in MMD patients. The results of each predictor were pooled by meta-analysis and further analyzed by subgroup analysis for predictors of unilateral to bilateral progression of MMD.ResultsA total of 842 patients from 12 studies were included. The estimated pooled means indicated lower age (standard mean difference [SMD]: −0.29, 95% confidence interval [CI]: −0.55 to −0.03; P = 0.03), family history (odds ratio [OR] 3.97, 95% CI: 1.96 to 8.03; P &lt; 0.001) and contralateral abnormality (OR 3.95, 95% CI: 1.10 to 14.20; P = 0.04) were associated with progression in MMD patients. Subgroup analyses indicated that the same three factors were associated with the progression of unilateral to bilateral MMD.ConclusionsThis meta-analysis revealed that lower age, family history and contralateral abnormality were associated with progression in MMD patients. The same three factors are associated with the progression of unilateral to bilateral MMD. Further studies are needed to validate our results.
Hotspots and trends in fNIRS disease research: A bibliometric analysis
Authors: Ye Xiangyin , Peng Li , Sun Ning , He Lian , Yang Xiuqiong , Zhou Yuanfang , Xiong Jian , Shen Yuquan , Sun Ruirui , Liang Fanrong 
Published: March 2023

ObjectiveTo summarize the general information and hotspots of functional near-infrared spectroscopy (fNIRS)-based clinical disease research over the past 10 years and provide some references for future research.MethodsThe related literature published between 1 January 2011 and 31 January 2022 was retrieved from the Web of Science core database (WoS). Bibliometric visualization analysis of countries/regions, institutions, authors, journals, keywords and references were conducted by using CiteSpace 6.1.R3.ResultsA total of 467 articles were included, and the annual number of articles published over nearly a decade showed an upward trend year-by-year. These articles mainly come from 39 countries/regions and 280 institutions. The representative country and institution were the USA and the University of Tubingen. We identified 266 authors, among which Andreas J Fallgatter and Ann-Christine Ehlis were the influential authors. Neuroimage was the most co-cited journal. The major topics in fNIRS disease research included activation, prefrontal cortex, working memory, cortex, and functional magnetic resonance imaging (fMRI). In recent years, the Frontier topics were executive function, functional connectivity, performance, diagnosis, Alzheimer’s disease, children, and adolescents. Based on the burst of co-cited references, gait research has received much attention.ConclusionThis study conducted a comprehensive, objective, and visual analysis of publications, and revealed the status of relevant studies, hot topics, and trends concerning fNIRS disease research from 2011 to 2022. It is hoped that this work would help researchers to identify new perspectives on potential collaborators, important topics, and research Frontiers.
Investigating 99Mo output changes in high-sustainability uranium targets by modifying target volume and geometry
Authors: Raposio Robert , Braoudakis George , Rosenfeld Anatoly , Bedwell-Wilson Juniper , Thorogood Gordon 
Published: March 2023

Introduction: The most common current uranium target type for 99Mo production uses plate geometry. This paper investigates the effects of geometry on 99Mo output and target sustainability.Methods: MCNP6.2 was used to model rectangular, spherical, and cylindrical targets ranging from 12.03 cm3 to 120.34 cm3 to determine the target geometry and volume effects on 99Mo output, sustainability, proliferation concerns, and heating. 4-7 days irradiation was used with a consistent target density of 2 g/cm3 UO2 for all target types.Results and Discussion: The cylindrical target was found to have the best performance due to having the second highest sustainability, the highest 99Mo output and produce the lowest amounts of 239Pu compared to the other target geometries. The heating comparison showed that there were negligible heating concerns for all target volumes and geometries.
Association between dietary minerals and glioma: A case-control study based on Chinese population
Authors: Zhang Weichunbai , He Yongqi , Kang Xun , Wang Ce , Chen Feng , Kang Zhuang , Yang Shoubo , Zhang Rong , Peng Yichen , Li Wenbin 
Published: March 2023

BackgroundAs one of the essential nutrients for the human body, minerals participate in various physiological activities of the body and are closely related to many cancers. However, the population study on glioma is not sufficient.ObjectiveThe purpose of this study was to evaluate the relationship between five dietary minerals and glioma.MethodsA total of 506 adult patients with glioma and 506 healthy controls were matched 1:1 according to age (±5 years) and sex. The food intake of the subjects in the past year was collected through the food frequency questionnaire, and the intakes of calcium, magnesium, iron, zinc, and copper in the diet were calculated. The logistic regression model was used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) for dietary minerals to gliomas.ResultsAfter adjusting for confounders, higher intakes of calcium (OR = 0.65, 95% CI: 0.57–0.74), magnesium (OR = 0.18, 95% CI: 0.11–0.29), iron (OR = 0.04, 95% CI: 0.02–0.11), zinc (OR = 0.62, 95% CI: 0.54–0.73), and copper (OR = 0.22, 95% CI: 0.13–0.39) were associated with a significantly decreased risk of glioma. Similar results were observed in gliomas of different pathological types and pathological grades. The restriction cubic spline function suggested significant linear dose-response relationships between intakes of five minerals and the risk of glioma. When the dietary minerals exceeded a particular intake, the risk of glioma stabilized.ConclusionOur study suggests that higher dietary intakes of calcium, magnesium, iron, zinc, and copper are associated with a decreased risk of glioma. However, the results of this study require further exploration of potential mechanisms in the future better to elucidate the effects of mineral intake on gliomas.
Dietary B vitamins and glioma: A case–control study based on Chinese population
Authors: Zhang Weichunbai , Jiang Jing , Kang Xun , Wang Ce , Chen Feng , Zhang Botao , Li Shenglan , Huang Sijie , Li Wenbin 
Published: March 2023

BackgroundDietary antioxidants have long been thought to be likely to prevent the development of gliomas. Previous studies have reported vitamin A, C, and E protective effects against gliomas. B vitamins, one of the main vitamins in the diet, are closely related to human health, but the association with gliomas has rarely been reported.ObjectiveThis study aimed to evaluate the relationship between five B vitamins and glioma.MethodsIn this Chinese population-based case–control study, 506 glioma cases and 506 matched (age and sex) controls were included. The dietary intake of study participants was assessed using a valid 111-item food frequency questionnaire. The intake of five B vitamins was calculated based on participants’ dietary information from the food frequency questionnaire. The logistic regression model was used to examine the association between B vitamins and glioma, and the restriction cubic spline evaluated the dose–response relationship between the two.ResultsAfter adjusting for confounding factors, thiamine (OR = 0.09, 95%CI: 0.05–0.20), riboflavin (OR = 0.12, 95%CI: 0.06–0.25), nicotinic acid (OR = 0.24, 95%CI: 0.12–0.47), folate (OR = 0.07, 95%CI: 0.03–0.15) and biotin (OR = 0.14, 95%CI: 0.07–0.30) in the highest tertile were associated with a significantly decreased risk of glioma compared with the lowest tertile. The results of thiamine and biotin in glioma with different pathological types and grades were different. The restricted cubic spline function showed significant dose–response relationships between the intake of five B vitamins and the risk of glioma. When B vitamins exceeded a specific intake, the risk of glioma did not change.ConclusionOur study suggests that higher dietary intake of thiamine, riboflavin, nicotinic acid, and folate are associated with a decreased risk of glioma, but the results of biotin are not consistent among different populations. In the future, prospective studies should be conducted better to validate the effects of B vitamins on gliomas.
Case report and literature review: PET/CT in the evaluation of response to treatment of liver metastasis from colorectal cancer with DEBIRI-TACE
Authors: Jin Lan , Hu Wuyun , Li Teng , Sun Honghua , Kang Dongxu , Piao Longzhen 
Published: March 2023

BackgroundIrinotecan-loaded drug-eluting beads transarterial chemoembolization (DEBIRI-TACE) is a safe and effective therapeutic option for unresectable colorectal liver metastases (CRLM). The evaluation of treatment response after DEBIRI-TACE is very important for assessing the patient’s condition. At present, the Response Evaluation Criteria in Solid Tumors (RECIST) with the tumor size obtained by CT and/or MRI and PET Response Criteria in Solid Tumors (PERCIST) based on fluorodeoxyglucose-positron emission tomography/computed tomography (FDG PET/CT) are used for evaluating the response to therapy of solid tumors; however, their value in the assessment of treatment response after DEBIRI-TACE remains unclear.Case presentationA 52-year-old male with unresectable simultaneous CRLM was treated in the Affiliated Hospital of Yanbian University with DEBIRI-TACE combined with systemic chemotherapy and targeted therapy. Carcinoembryonic antigen levels decreased by 82.50% after 27 days of treatment. At 6 weeks post-surgery, FDG-PET/CT showed that the maximum standardized uptake value (SUVmax) of intrahepatic lesions was reduced to 62.14%. Abdominal MRI revealed that the sum of target lesion diameters was less than 30% that at baseline. PERCIST indicated partial metabolic response, whereas RECIST suggested stable disease.ConclusionFDG PET/CT-based PERCIST may be accurate in determining treatment response and evaluating patient prognosis after DEBIRI-TACE in unresectable CRLM.
Mendelian randomization eradicates the causal relationship between educational attainment, household income, and oropharyngeal cancer
Authors: Qi Li , Bao Wenzhao , Wang Sai , Ding Xiaoxu , Li Wei 
Published: March 2023

BackgroundIt was reported that educational attainment and household income are associated with oropharyngeal cancer. However, whether such an association is causal is still unknown.MethodsThe Mendelian randomization (MR) design was performed to disentangle their causal relationship. Initially, genetic variants proxied for educational attainment and household income were extracted from the largest genome-wide association studies (GWAS), and two oropharyngeal GWAS datasets were used in the discovery and validation stages separately. A reverse MR analysis was carried out to judge whether oropharyngeal cancer affects educational attainment and household income. The results from the two stages were combined using meta-analysis. The heterogeneity and horizontal pleiotropy were appraised using several methods.ResultsAll selected genetic variants were valid. In the discovery stage, genetically elevated years of education might decrease the risk of oropharyngeal cancer (IVW OR = 0.148 [0.025, 0.872], p-value = 0.035), while such a result became insignificant in the validation stage (IVW p-value &gt;0.05). Household income cannot change the risk of oropharyngeal cancer at both stages. The reverse MR suggested that oropharyngeal cancer should slightly alter household income (IVW OR = 1.001 [1.000, 1.003], p-value = 0.036) in the discovery set, but the result cannot be replicated in the validation stage. The meta-analysis did not find any significant results either. The results were also assessed by sensitivity analyses, and there was no heterogeneity or horizontal pleiotropy in the analyses. The statistical powers were all above 80% at the discovery stage.ConclusionsThere should be no causal association between educational attainment, household income, and oropharyngeal cancer.
Relationship between night-sleep duration and risk for depression among middle-aged and older people: A dose–response meta-analysis
Authors: Li Xin-lin , Wei Jiayin , Zhang Xinying , Meng Zhuo , Zhu Wentao 
Published: March 2023

Objective: The study aimed to examine the dose–response associations between night-sleep duration and depression risk in middle-aged and older adults.Methods: We searched PubMed, Embase, Web of Science, CNKI, VIP, and the Wanfang data knowledge service platforms from inception to 31 July 2022. Cohort and case–control studies assessing the relationship between night-sleep duration and depression were selected. We used the Newcastle–Ottawa scale to assess the quality of the published research. Two researchers carried out data extraction and quality assessment. The restricted cubic spline function and generalized least squares method were used to establish dose–response relationships between sleep duration and depression. We aimed to analyze the estimated effect size presented as the risk ratio (RR) and its 95% confidence interval (CI) using Stata 12.0.Result: Six cohort studies with 33,595 participants were included in this meta-analysis. A U-shaped association between sleep duration and depression risk was revealed. On one hand, compared with 7-h of night sleep, both shorter and longer sleep duration were associated with an increased risk of depression (5 h: risk ratio = 1.09, 95% confidence interval = 1.07–1.12; 6 h: RR = 1.03, 95% CI = 1.02–1.04; 8 h: RR = 1.10, 95% CI = 1.05–1.15; 9 h: RR = 1.31, 95% CI = 1.17–1.47; 10 h: RR = 1.59, 95% CI = 1.31–1.92; non-linear test p &lt; 0.05). On the other hand, an increased risk of depression with shorter sleep duration was observed in middle-aged and older people among the non-Asian population (5 h: RR = 1.09; 95% CI = 1.02–1.17), while both shorter and longer sleep duration can increase the risk of depression among an Asian population (5 h: RR = 1.10, 95% CI = 1.07–1.13; 6 h: RR = 1.04, 95% CI = 1.02–1.05; 8 h: RR = 1.09, 95% CI = 1.05–1.14; 9 h: RR = 1.35, 95% CI = 1.18–1.53; 10 h: RR = 1.70, 95% CI = 1.36–2.12).Conclusion: The lowest-risk onset of depression occurred among middle-aged and older people with 7 h of night sleep, which suggested that shorter and longer night-sleep duration might lead to an increased incidence of depression.Clinical Trial Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=344052, identifier 344052
Performance of two egg parasitoids of brown marmorated stink bug before and after cold storage
Authors: Li Wen-Jing , Chen Ju-Hong , Avila Gonzalo A. , Ali Muhammad-Yasir , Tian Xin-Yue , Luo Zheng-Yu , Zhang Feng , Shi Shu-Sen , Zhang Jin-Ping 
Published: March 2023

Introduction: The genus Trissolcus includes a number of egg parasitoids that are known to contribute to the control of Halyomorpha halys. The number of progenies, particularly females, is important for the efficient mass rearing of species used in augmentative biological control programs. Cold storage is an important technique for extending the shelf life of natural enemies used in such programs.Methods: We assessed how fecundity, sex ratio, lifespan, and the number of hosts parasitized within 24 h were affected by host density for T. japonicus and T. cultratus when offered fresh H. halys eggs and how these parameters were affected if adult parasitoids were first placed in cold storage (11°C in the dark) for 19 weeks before being used for propagation.Results: The fecundity were 110.2 and 84.2 offspring emerged at 25°C, for parasitoids not placed in cold storage; among the offspring that emerged, 82.6% and 85.6% were female for T. japonicus and T. cultratus, respectively. If first placed in cold storage, T. japonicus and T. cultratus produced 35.1 and 24.6 offspring per female, respectively, although cold storage significantly extended the shelf life. The survival rates of parasitoids that were placed in cold storage were 90.3% and 81.3% for females, and 3.2% and 0.9% for males of T. japonicus and T. cultratus, respectively. The number of hosts parasitized within 24 h was not shown to be density dependent, but it was significantly lower after cold storage.Discussion: This information can be used to estimate the likely production for augmented rearing colonies for use in biological control programs.
The association between self-reported sleep problems, infection, and antibiotic use in patients in general practice
Authors: Forthun Ingeborg , Eliassen Knut Eirik Ringheim , Emberland Knut Erik , Bjorvatn Bjørn 
Published: March 2023

ObjectivesThere is emerging evidence that sleep problems and short sleep duration increase the risk of infection. We aimed to assess whether chronic insomnia disorder, chronic sleep problems, sleep duration and circadian preference based on self-report were associated with risk of infections and antibiotic use among patients visiting their general practitioner (GP).MethodsWe conducted a cross-sectional study of 1,848 unselected patients in Norway visiting their GP during 2020.The patients completed a one-page questionnaire while waiting for the consultation, that included the validated Bergen Insomnia Scale (BIS), questions on self-assessed sleep problem, sleep duration and circadian preference and whether they have had any infections or used antibiotics in the last 3 months. Relative risks (RR) were estimated using modified Poisson regression models.ResultsThe risk of infection was 27% (95% CI RR 1.11–1.46) and 44% higher (95% CI 1.12–1.84) in patients sleeping &lt; 6 h and &gt;9 h, respectively, compared to those sleeping 7–8 h. The risk was also increased in patients with chronic insomnia disorder or a chronic sleep problem. For antibiotic use, the risk was higher for patients sleeping &lt; 6 h, and for those with chronic insomnia disorder or a chronic sleep problem.ConclusionsAmong patients visiting their GP, short sleep duration, chronic insomnia and chronic sleep problem based on self-report were associated with higher prevalence of infection and antibiotic use. These findings support the notion of a strong association between sleep and infection.