bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Cutting Tool Edge Geometry Design based on SVR-PSO
Authors: Jiang Yimin , Huang Wei , Tian Yu , Yang Mingyang , Xu Wenwu , An Yanjie , Li Jing , Li Junqi , Zhou Ming 
Published: August 2023

Abstract
In order to optimize the design of tool edge, an intelligent method was used for modeling and optimization. The tool edge design method based on Support Vector Regression (SVR) and Particle Swarm Optimization (PSO) was proposed. By combining tool edge parameters and processing condition parameters, and learning from empirical data, a functional model was established between tool life, edge parameters, and processing condition parameters. Taking the tool life as the objective function, the optimal edge profile design parameters were solved under different processing condition parameters. The T-shape tool validates was taken as a case for verification. The SVR-PSO function model was established and solved based on the processing condition parameters, and the optimized edge design parameters and predicted tool life were obtained. The results showed that the deviation between the calculated and actual tool life was less than 6.4%. This method was feasible and practical, and has been applied in the design department of tool manufacturing companies.
The Safety and Efficacy of Sotn ureteroscopy for Renal and Upper Ureteral Calculi: A Prospective Multicenter Randomized Controlled Trial
Authors: Guo Zhenlang , Wang Zhichao , Weng Xiangtao , Tang Yanquan , Wu Deneng , Cheng Fan , Chen Bin , Tang Huilong , Cui Jinsheng , Gu Chiming , Zou Qianming , Li Yuan , Gan Shu , Xiang Songtao , Wang Shusheng 
Published: August 2023

Abstract
Purpose
Sotn ureteroscopy is a new lithotripsy procedure developed on the basis of ureteroscopy and includes a rigid ureteral access sheath, standard mirror, lithotripsy mirror, and Sotn perfusion aspirator. Thus, we performed a prospective multicenter randomized controlled trial comparing the safety and efficacy of Sotn ureteroscopy in the treatment of renal and upper ureteral calculi.
Materials and Methods
224 patients with renal and upper ureteral calculi were randomly divided equally into study and control groups from March 2018 to March 2022. All of the patients were approved by the hospital ethics committee (proof number: ZF-2018-164-01 and ZF-2018-165-01) of the Second Affiliate Hospital of Guangzhou University of Chinese Medicine in China. The primary outcome was stone-free rate (SFR) assessed by computed tomography on the 1st day and month after treatment and operation duration. The secondary outcome was postoperative complication rate.
Results
In total, for upper ureteral calculi, the SFR of 1 day after operation of the Sotn ureteroscopy group was significantly higher than the rigid ureteroscopy group (83.6% vs. 60%, P = 0.006). Moreover, operative time (33.7 ± 1.80 vs. 52.9 ± 2.73 min, P < 0.005) of the Sotn ureteroscopy group was significantly lower than the rigid ureteroscopy group. Additionally, the SFR of 1 day after operation and operative time for the study group (Sotn ureteroscopy combined with flexible ureteroscopy) and the control group (flexible ureteroscopy alone) were 63.2% and 36.8% (P = 0.005), 65.6 ± 4.06 and 80.3 ± 4.91 (P = 0.023), respectively. However, there were no significant differences in the SFR of 1 month after operation, success rate of ureteral access sheath placement, and postoperative complications between the two groups (P > 0.05). In subgroups with stone diameters ≥ 1.5 cm and stone CT values ≥ 1,000 Hounsfield units, Sotn ureteroscopy showed more advantages in terms of the SFR of 1 day after operation. Importantly, complications such as ureteral injury, sepsis, fever and severe haematuria were not statistically different between the two groups (P > 0.05).
Conclusions
For renal and upper ureteral calculi, Sotn ureteroscopy has the advantage of a higher SFR of 1 day after the operation, a shorter operative time and low complication rates, suggesting that the Sotn ureteroscopy may have further potential applications in clinics.
Coaxial electrospinning of Au@silicate/poly(vinyl alcohol) core/shell composite nanofibers with noncovalently immobilized gold nanoparticles to prepare flexible, freestanding, and highly sensitive SERS substrates amenable to large-scale fabrication
Authors: Chen Yan-Feng , Lee Yen-Chen , Lee Jimmy Chi-Min , Chiu Chih-Wei 
Published: August 2023

Abstract
In this study, coaxial electrospinning was used to prepare novel core/shell composite nanofiber films for use as substrates in surface-enhanced Raman spectroscopy (SERS). The shell layer was composed of Au@silicate nanohybrids, i.e., Au nanoparticles (AuNPs) immobilized in silicate nanosheets via electrostatic attraction. The core layer consisted of polyvinyl alcohol (PVA), which functioned as the mechanical support of the composite nanofibers. By using coaxial electrospinning to form the Au@silicate/PVA core/shell composite nanofibers, the Au@silicate nanohybrids were uniformly dispersed on the PVA nanofibers. Transmission electron microscopy revealed that the AuNPs immobilized on the silicate nanosheets had particle sizes of 25–30 nm and uniform spherical shapes. Furthermore, the core/shell composite nanofiber film had a three-dimensional network structure owing to its formation via random deposition. Compared with the uniaxially electrospun nanofibers, the core/shell composite nanofibers required a significantly lower AuNP content to achieve the same SERS sensitivity. Furthermore, the Au@silicate nanohybrid shell layer increased the ultimate tensile strength by a factor of almost 1.5. In SERS experiments, the uniaxially electrospun nanofiber had an enhancement factor (EF) of 4.1 × 104, whereas the coaxially electrospun nanofiber had an EF of 1.7 × 105. It was demonstrated that our nanofiber can be used for environmental, food safety, and biomedical applications, as it has a detection limit of 10-7 M and EF of 2.5 × 105 for Direct Blue 200 (an industrial dye) and detection limits lower than 10-6 M for paraquat (a pesticide) and adenine (a biomolecule). Therefore, Au@silicate/PVA core/shell composite nanofibers can be used to prepare portable, flexible, freestanding, and stable SERS substrates that are amenable to large-scale fabrication. Furthermore, films prepared using Au@silicate/PVA core/shell composite nanofibers are less susceptible to the “coffee ring” effect observed in conventional droplet coatings, which improves the reproducibility and uniformity of SERS analysis. The developed SERS substrate has a wide range of applications, and the findings of this study are expected to improve sensor technologies for environmental, food safety, and biomedical applications.
Synthesis, Crystal Structure and Catechol Oxidase Activity of a Di- nuclear Paddle-Wheel Cu (II) Carboxylate Complex
Authors: Chakraborty Priyanka , Chatterjee Abhishikta , Kumar Bidyapati , Mondal Sourav , Dey Subrata 
Published: August 2023

Abstract
A dinuclear copper (II) complex, Cu2 (RCOO)4(L)2 (1) while [RCOO = benzoate, L = 2-amino-3-chloro-5-trifluoro methyl pyridine], with square pyramidal geometry with four carboxylate bridged groups has been reported. This dinuclear copper (II) unit (with the most robust, frequently occurring paddle wheel structure) was characterised by single crystal X-ray diffraction, IR, UV, CV, TGA and EPR studies. It exhibits catechol oxidase activity in methanol medium and the catecholase activity was monitored by the UV–Vis spectroscopy. The kinetic parameters have been determined by using Michaelis–Menten equation which shows that the complex is an efficient catalyst with very high turnover number. Mechanistic investigation of the catalytic behavior was established with the help of ESI-MS spectra.
Estimating Soil-Water Characteristic Curve (SWCC) Using Machine Learning and Soil Micro-Porosity Analysis
Authors: Bakhshi Aida , Alamdari Parisa , Heidari Ahmad , Mohammadi Mohmmad Hossein 
Published: August 2023

Abstract
The soil water characteristic curve (SWCC) reveals soil porosity and soil-water interactions at different matric suctions. Numerous methods, such as laboratory determination, CT-scan, image analysis, and predictive models, have been employed to investigate soil porosity system and their correlation with the SWCC. Image analysis techniques offer valuable insight into soil pore system, providing data that cannot be obtained by other methods. This study aims to compare the role of image analysis technique in reconstructing the SWCC with the laboratory measurement method. Eight machine learning models and algorithms, including Gradient Boosting (GB), Ada Boost (AB), Decision Tree (DT), Random Forest (RF), Artificial Neural Network (ANN), Support Vector Machine (SVM), K-Nearest Neighborhood (KNN), and Linear Regression (LR), were utilized for the reconstruction of the SWCC using the Orange-3 data mining software. The predicted SWCCs by models were compared with the measured SWCC. The models used to reconstruction of SWCC were categorized as capable and incapable to SWCC prediction. Four statistical parameters, namely RMSE, MAE, Willmott’s index of agreement (d1), and R2, were utilized to assess the performance of the models using all input data. The GB, AB, DT were the top best models in correct prediction of SWCC. Among them the GB model achieved near-perfect predictions, with RMSE, MAE, d1, and R2 values of 0.016, 0.011, 0.94, and 0.982, respectively. However, when the matric suction was used as only input data, the performance of all the models declined. This study demonstrates that Orange-3 is user friendly software to predict SWCC, without labor preprocessing activities.
Characterization of Salmonella spp. in a tertiary hospital during 2019-2021 in Nanjing, China: Focusing on the clonal dissemination of Salmonella Enteritidis ST11
Authors: Hua Miao-Miao , Li Jia , Zheng Jie , Wang Jing-Jing , Zhang Yan , Zhang Zhi-Feng , Cao Xiao-Li , Shen Han 
Published: August 2023

Abstract
Background
An increasing prevalence of Salmonella spp. involving various infections in our hospital has been recently found and the characterization of these strains remained unknown.
Methods
A total of 38 clinical Salmonella enterica isolates were implemented for antimicrobial susceptibility testing, slide agglutination tests, and multi-locus sequence typing. WGS was performed to analyze the serovars, antibiotic-resistance genes (ARGs), virulence factors (VFs), sequence types (STs) and plasmid replicons. Phylogenetic tree was constructed to investigate the genetic relationship.
Results
Thirteen serovars were identified with Enteritidis (n = 19, 50.0%) being the most common, followed by Typhimurium (n = 4, 10.5%). High resistances against ampicillin (n = 27, 71.1%) and ampicillin/sulbactam (n = 24, 63.2%) were observed and 7 (18.4%) isolates were found to be multidrug resistant (MDR). Totally, 36 types of ARGs were detected with blaTEM-1B (n = 25, 65.8%) being the most frequent, and mutations in gyrA and/or parC were identified in 34 (89.5%) strains. Notably, 333 different VFs were detected, amongst them, 177 ones were shared by all isolated Salmonella strains. ST analysis identified 15 distinct STs with ST11 being the most predominant one, where a close genetic relationship between them was shown by the phylogenetic tree. Ten different plasmid replicons were found, with a dominance of IncFIB(S), IncFII(S), and IncX1 within S. Enteritidis (94.7%).
Conclusions
More Salmonella serovars have been identified with new molecular detection technique being developed. In addition to the high resistance and potential pathogenicity displayed by the Salmonella spp., the clonal dissemination of S. Enteritidis ST11 alerts us the necessity and urgency to implement infection and control measures.
Miniaturized Longitudinal Substrate Integrated Waveguide Slot Array Antenna for Triband 5G- millimeter-wave -wave Applications
Authors: M Benisha , V Thulasi Bai 
Published: August 2023

Abstract

A miniaturized triband longitudinal Substrate Integrated Waveguide (SIW) slot array antenna for the millimeter-wave (mm-wave) communication - Fifth Generation (5G) application was suggested in this contribution. The antenna is developed with 4 slots over a Rogger 5880 dielectric material with 2.2 dielectric constant, 1.6mm thickness, and with 52 series metallic via's to operate in multiple bands covering mm-wave range. A SIW antenna fed with microstrip and in turn to SIW transition is involved in the design. Proposed SIW array slot antenna simulation has been carried out using Computer Simulation Technology (CST) EM simulator and fabricated. The results obtained indicate, 3 different resonant frequency bands such as 21GHz, 28 GHz, and 32 GHz & providing a fine antenna gain as 6.56, 6.55, and 8.6 dBi respectively obtained from the designed antenna. The proposed SIW structure was also seen offering an improved return loss of below 30 dB and Voltage Standing Wave Ratio (VSWR) value below 2, which is the highly anticipated one for a good antenna. The proposed antenna size is very less when compared with the other antennas which is also an important consideration for future wireless applications. An analysis has been made between simulated and measured parametric values, from that it can be found as a good candidate for improving global bandwidth limitations and apposite for triple-band 5G wireless applications.
Unraveling the Complexity: Expression Patterns and Prognostic Value of Cell Adhesion Junction Regulatory Genes in Hepatocellular Carcinoma
Authors: Jin Yuanyang , Zhang Yajuan , Xie Guanghao , Suo Zhimin 
Published: August 2023

Abstract

This study investigates the impact of cell adhesion junction-related genes on the prognosis of primary hepatocellular carcinoma (HCC) while exploring potential correlations between adhesion junction mechanisms and the tumor immune microenvironment. A total of 60 cell adhesion junction-related genes were carefully analyzed to construct a risk signature. Through differential expression, univariate Cox, and LASSO analyses, combined with patient data from the TCGA database, the risk signature's validity was rigorously confirmed using survival analysis and independence testing. Further exploration involved analyzing the model's correlation with the tumor immune microenvironment and its responsiveness to common therapeutic drugs. The study identified ten adherens junction-related genes integral to the risk signature, with FYN and PTPRB acting as protective effectors of HR < l, and PARD3, SSX2IP, RAC3, CDC42, NECTIN1, WASF1, RAC1, and SMAD2 serving as risk effectors of HR > l. Notably, the low-risk group exhibited significantly improved prognosis (p < 0.0001), with respective area under the curve (AUC) values at 1, 3, and 5 years of 0.799, 0.708, and 0.645. Furthermore, the low-risk subgroup displayed heightened immune cell activity, whereas the high-risk group demonstrated elevated expression of specific immune checkpoints, indicating a potential benefit from immunotherapy. The G2M checkpoint, PI3k-AKT-mTOR signaling pathway, DNA damage repair, and MTORC1 signaling pathway were positively associated with the risk score, offering crucial insights into the underlying mechanisms at play.
The causal relationship of gut microbiota in progression of seven common hematological malignancies
Authors: he xiaoyu , Nie Duorui , Yang Kaiqian , Wang Xiaofang , Jiang songfu 
Published: August 2023

Abstract
Purpose: Evidence from observational researches and clinical trials showed the relationship between gut microbiomes (GMs) and hematological malignancies. Nevertheless, the causal role of GM taxa in development of hematological malignancies remains to be explored. Therefore, we aim to assess the causal links between 196 GM taxa and seven common hematological malignancies using the two-sample Mendelian randomization (MR) analyses.
Methods: All datasets were derived from published genome-wide association studies (GWAS) statistics. The primary analysis was performed using random effects inverse variance weighted (IVW). To verify the robustness of the MR results, we performed several sensitivity analyses such as Egger intercept test, the Cochran Q test, MR pleiotropy residual sum and outlier (MR-PRESSO), and leave-one-out analysis.
Results: We revealed the family Oxalobacteraceae would increase the risk of myeloid leukemia by the Bonferroni correction [odds ratio (OR): 2.08, 95% CI: 1.49, 2.90, p = 1.68E-05]. In addition, 22 nominally significant associations between genetic liability in GMs and hematological malignancies were also found (P < 0.05). Sensitivity analysis verified the robustness of the above causal relationships.
Conclusion: This study confirms the causal relationship between GMs and hematological malignancies and may provide new insights to the mechanistic and clinical researches of GM-mediated hematological malignancies.
Bimodal disruption of the crosstalk between cancer cells and fibroblasts using nanomedicine augments cancer immunotherapy
Authors: Elzoghby Ahmed , Freag May , Mohammed Mostafa , Kulkarni Arpita , Emam Hagar , Maremanda Krishna 
Published: August 2023

Abstract
Cancer cells program fibroblasts into a pro-tumorigenic and immunosuppressive cancer associated fibroblasts (CAFs) in a two-step manner. First, cancer cells secrete exosomes to reprogram quiescent fibroblasts into the activated CAF phenotype. Second, cancer cells maintain the CAF phenotype via activation of signal transduction pathways in the fibroblasts. We rationalized that inhibiting this two-step process can normalize the CAFs into quiescent fibroblasts and augment the efficacy of immune checkpoint inhibitors. We show that a cancer cell-targeted dual-drug combination nanomedicine that inhibits the sequential steps of exosome biogenesis and release from lung cancer cells can block the differentiation of lung fibroblasts into CAFs. In parallel, we demonstrate that a CAF-targeted dual-drug nanomedicine that blocks two distinct nodes in the FGFR-Wnt/β-catenin signal transduction pathway can reverse activated CAFs to a quiescent fibroblast state. Co-administration of both nanomedicines significantly improves the infiltration of cytotoxic T cells and enhances the antitumor efficacy of αPD-L1 antibody in an immunocompetent mice model of lung cancer. Simultaneously blocking the tumoral exosome-mediated activation of fibroblasts and FGFR-Wnt/β-catenin signaling axes may constitute a promising approach to augment immunotherapy.
Investigation of the Binary Cation Effect and the Irradiance Level Dependence on the Efficiency of Dye-sensitized Solar Cells
Authors: Wickramasinghe H. M. N. , Karunathilaka N. G. A , Gnanarathne D. M. T. , DeSilva L. Ajith. , Bandara Thennakoon 
Published: August 2023

Abstract
The development of photoelectrochemical energy conversion devices holds immense significance in addressing the escalating demand for energy and the depleting supply of nonrenewable energy sources. Dye-sensitized solar cells (DSSCs) need improvements to make them a competitive contender for 1st and 2nd generation solar cells. The development of suitable electrolytes for highly performing DSSCs is critical for that purpose. By harnessing the synergistic effects of salt mixtures that encompass both large and small counter ions, notable advancements in DSSC performance have been realized. The investigated DSSCs with a novel organic electrolyte complex that contains LiI and (tetrahexylammonium) Hex4NI exhibited significant efficiency enhancement compared to that of their individual salt end components. The ionic conductivity variations and frequency-dependent AC conductivity in the electrolyte, and dielectric properties were analyzed using complex impedance data. The conductivity in the electrolyte at room temperature is 11.44 mS cm− 1. The investigated DSSCs are comprised of improved TiO2 multi-layer photoelectrodes and Pt counter electrodes. Under an irradiance of 1000 W m− 2, the energy conversion efficiency of the binary salt system reached 8.37%, marking an impressive enhancement of 86.83% and 76.21% compared to the Hex4NI and LiI-based single salt counterparts, respectively. The associated open-circuit voltage, fill factor, and short-circuit current density values are 710 mV, 0.69, and 16.33 mA cm− 2. Additionally, an impressive efficiency of 10.57% is shown when the light intensity drops to 400 W m− 2. Furthermore, the cells exhibited commendable short-term stability, likely attributed to the elimination of volatile solvents in the electrolyte. This study underscores the pivotal role played by binary counter ions in the electrolyte, as they elicit synergistic effects that amplify DSSC performance enhancements, effectively overshadowing the effects imposed by conductivity variation.
Anterior chamber and angle characteristics in Chinese children (6-11 years old) with different refractive status using swept-source optical coherence tomography
Authors: Zhao Li Li , Lu Xiu Zhen , Tang Guo Dong , Zhang Xiu Yan , Li Run Kuan , Xu Jing , Feng Jiao Jiao , Xu Zhe , Song Ji Ke , Bi Hong Sheng 
Published: August 2023

Abstract

Purpose
To quantify and analyze the anterior chamber (AC) and angle (ACA) characteristics in Chinese children with different refractive status by swept-source optical coherence tomography (SS-OCT).
Methods
In a cross-sectional observational study, 383 children from two primary schools in Shandong Province, China, underwent a complete ophthalmic examination. First, the anterior chamber depth (ACD), anterior chamber width (ACW), angle-opening distance (AOD), and trabecular-iris space area (TISA) were evaluated automatically using a CASIA2 imaging device. AOD and TISA were measured at 500, 750µm nasal (N1 and N2, respectively), and temporal (T1 and T2, respectively) to the scleral spur (SS). Cycloplegic refraction and axial length (AL) were then measured. According to spherical equivalent refraction (SER), the children were assigned to hyperopic (SER > 0.50D), emmetropic (-0.50D < SER ≤ 0.50D), and myopic groups (SER ≤ -0.50D).
Results
Out of the 383 children, 349 healthy children (160 girls) with a mean age of 8.23 ± 1.06 years (range: 6–11 years) were included. The mean SER and AL were − 0.10 ± 1.57D and 23.44 ± 0.95mm, respectively. The mean ACD and ACW were 3.17 ± 0.24mm and 11.69 ± 0.43mm. The mean AOD were 0.72 ± 0.25, 0.63 ± 0.22mm at N1, T1, and 0.98 ± 0.30, 0.84 ± 0.27mm at N2, T2. The mean TISA were 0.24 ± 0.09, 0.22 ± 0.09mm2 at N1, T1, and 0.46 ± 0.16, 0.40 ± 0.14mm2 at N2, T2. The myopic group had the deepest AC and the widest angle. Compared with boys, girls had shorter AL, shallower ACD, narrower ACW, and ACA (all p < 0.05). By Pearson’s correlation analysis, SER was negatively associated with ACD, AOD, and TISA. AL was positively associated with ACD, ACW, AOD, and TISA. In the multiple regression analysis, AOD and TISA were associated with deeper ACD, narrower ACW, and longer AL.
Conclusion
In primary school students, the myopic eyes have deeper AC and wider angle. ACD, ACW, AOD, and TISA all increase with axial elongation. ACA is highly correlated with deeper ACD.