bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation on large-scale 3D seepage characteristics of a pumped-storage power station: a case study in Zhejiang Province, China
Authors: Li Jiabei , Zhang Sherong , Wang Chao , Jiang Zhiyong , Zheng Jun , Wang Xiaohua , Lu Tong 
Published: September 2023

Abstract
Pumped-storage power stations (PSPSs) have higher requirements for anti-seepage compared with regular power stations. As a result, investigating the seepage distributions of PSPSs is particularly important. However, existing researches remain limited in assessing engineering needs such as ensuring the efficiency of a power station. Taking the Qingyuan PSPS as a typical case, this study aims to investigate the large-scale seepage field distribution while exploring the efficiency of the anti-seepage system. Considering the geological characteristics and structural location, a 3D finite element model is established. Based on the continuous medium model while combined with seepage control measures, the change in leakage while the anti-seepage system failed is further assessed. It is concluded that the operation status of anti-seepage measures will have a certain impact on the leakage volumes of each part. Using a comprehensive assessment, anti-seepage measures can effectively prevent seepage. When failure occurs on anti-seepage curtains, the leakage volume at the corresponding position will show an obvious growth. In summary, the findings of this study highlight the significance of avoiding excessive leakage caused by anti-seepage structure failure, the effective operation of anti-seepage measures must be ensured. The abovementioned results can provide scientific support for the seepage optimization design of PSPSs.
PERFIL DO CONSUMO DOS BENZODIAZEPÍNICOS NOS ANOS DE 2019 E 2020 NO BRASIL E REGIÕES
Authors: Santiago Cláudia O'ara Azevedo , Lucena Elias Soares do Nascimento , Araújo Aurigena Antunes de 
Published: September 2023

Introdução: Os benzodiazepínicos estão entre os medicamentos mais prescritos, principalmente em países ocidentais, onde estimativas mostram um consumo anual de 1% a 3% da população. Objetivo: Estudar o perfil do consumo dos benzodiazepinicos entre 2019 e 2020. Metodologia: Foram estudadas a taxa de desocupação (IBGE), consumo dos benzodiazepínicos (SNGPC/ANVISA/Brasil) e quantidade de internações por envenenamento com exposição (acidental ou proposital), auto-intoxicação e efeitos adversos aos anticonvulsivantes, sedativos, hipnóticos, antiparkinsonianos e psicotrópicos (DATASUS). Resultados: Texto dos resultadosA taxa de desocupação aumentou em todo o Brasil em 2020 (13,5%). No Brasil houve um aumento de 9,81% no consumo de clonazepam industrializado em 2020, a maior alta foi na região Nordeste (22,52%). Em 2020 foram consumidos 38.743.825 capsulas de benzodiazepínicos manipulados, enquanto em 2019 foram 35.874.947 capsulas. Em 2019 foram 2.554 internações no território brasileiro e 1.814 em 2020, a principal causa foi auto-intoxicação por exposição intencional aos medicamentos, 61,2% em 2019 e 56,1% em 2020. Conclusões: Ocorreu um aumento no consumo de benzodiazepinicos industrial no ano de 2020 sendo a auto-intoxicação intencional por uso de medicamentos a principal causa de internação. Há necessidade de um controle do consumo e vigilância aos psicotrópicos visto que estes fármacos estão dentre aqueles com risco de internações devido a exposição acidental ou não, auto-intoxicação ou efeitos adversos.
A BUSCA POR UM FAZER COSTURADO DE POSSIBILIDADES E DESAFIOS: A ATUAÇÃO DO SANITARISTA NA ATENÇÃO PRIMÁRIA À SAÚDE DO CAMPO
Authors: Laurindo Alexsandro de Melo , Brito Mateus dos Santos , Freitas Priscylla Alves Nascimento de , Lago Thaiara Dornelles , Sousa Fabiana de Oliveira da Silva , Lages Itamar 
Published: September 2023

Introdução: As práticas de trabalho em saúde têm historicamente passado por transformações principalmente a partir dos processos de formação dos profissionais da saúde. O profissional sanitarista, ou bacharel em saúde coletiva vem somando esforços e ocupando espaços de trabalho multiprofissionais fortalecendo a perspectiva transversal do cuidado em saúde em diversos campos de atuação. Objetivo: Este estudo objetiva relatar a experiência de construção do processo de trabalho de um bacharel em Saúde Coletiva na Atenção Primária à Saúde do Campo em meio a pandemia de Covid-19. Metodologia: O período de abrangência foi de 2020 a 2022, ocorrendo no município de Caruaru/PE. A atuação do bacharel em Saúde Coletiva se deu na perspectiva do Núcleo de Apoio á saúde da familia e atenção básica (NASF-Ab), atuando junto a duas equipes de saúde da família de territórios rurais. Resultados: O processo de trabalho se desenvolveu em três principais frentes, sendo elas: 1) Atenção à saúde com base territorial; 2) Articulação com redes intra e intersetoriais; 3) Reorganização do trabalho multiprofissional na Atenção Primária à Saúde. Conclusões: Sendo assim, é possível constatar que o processo de trabalho do bacharel em Saúde Coletiva está em constante movimento, delimitando as suas possibilidades de atuação, bem como os seus limites quanto a um fazer ainda desconhecido em realidades como a APS. O avanço da discussão ocorre em paralelo a formação e inserção destes profissionais nos mais diversos contextos a exemplo da saúde do campo. Nota-se a necessidade de desenvolver novos estudos e experiências formativas de bachareis e saúde coletiva conectados aos territórios do campo, apostando na capilarização e ampliação da presença deste profissional nas realidades singulares do Sistema Único de Saúde (SUS).
CONSTRUÇÃO DO MAPA DE GRÁVIDAS COMO FERRAMENTA DE CONTROLE NO ENFRENTAMENTO DA COVID-19 EM BELÉM-PA: RELATO DE EXPERIÊNCIA.
Authors: Santos Pamela Farias , Mendes Iza Belle Rodrigues , Cardoso Aline Mendes , Gomes Cleiton da Costa , Góes Ana Cristina Costa , Silva Carolina  de Souza , Carvalho Dione Seabra de 
Published: September 2023

Introdução: No início de 2020 a organização mundial da saúde (OMS) declarou o período pandêmico pelo novo coronavírus, SARS-COV-2, agente etiológico da Covid-19, o qual tem se propagado pelo mundo. Diante disso, faz-se necessário refletir sobre as complicações durante a gestação e a importância do cuidado das enfermeiras a fim de superar esses desafios que perpassam esse contexto. Objetivo: Possibilitar o controle das gestantes através da tecnologia educacional do tipo mapa de grávidas. Metodologia: Trata-se de um estudo descritivo, do tipo relato de experiência com abordagem qualitativa. Resultados: A ideia inicial identificava as grávidas de acordo como o sexo do bebê, sendo que a produção dessas grávidas se dava através da utilização da folha do E.V.A. Logo, a gravida da cor verde indicava que o profissional não tinha conhecimento do sexo do bebê, a rosa identificava o sexo feminino e a azul o sexo masculino, porém ao longo das oficinas, este método de identificação foi modificado. Conclusões: A experiência de vivenciar este projeto observando o empenho dos profissionais em construir seu mapa e levar isso para sua unidade foi bastante satisfatória, uma vez que permite que os profissionais e discentes fortaleçam a autonomia do cuidar e consequentemente a prática laboral.
Palavras-Chave: Pandemia; Covid-19; Educação em saúde; Enfermagem; Odontólogos.
Thyroid Autoimmune Disease among Emirati Patients: A Retrospective
Analysis of the Patients’ Characteristics
Authors: Howeedy Aly , Zreik Raya , Gharaibeh Suzan 
Published: September 2023

Background:
Autoimmune thyroid disease (AITD) is a serious and treatable disease that could be associated with other autoimmune disorders. It is a common cause of hypothyroidism in adult females. The diagnosis is established by detecting serum antithyroid antibodies. The disease slowly progresses, and the treatment includes thyroid hormone replacement in cases of hypothyroidism.

Objective:
The aim of this study is to investigate the clinical presentation, laboratory findings, and comorbidity factors involved in autoimmune thyroid disease among Emirati citizens in the UAE.

Methods:
Medical records from Advanced Cure Diagnostic Centers were reviewed in a retrospective study over the period of four years from 2018 to 2022. The patients population included those who attended the Endocrinology Unit and others seen by the rest of the medical staff. Patients were considered to have AITD if they tested positive for thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb), or both. The data collected was evaluated using descriptive analysis to provide a basic summary of the patients sample and dataset. Unpaired t-test was used to compare the mean value of elevated autoantibodies in males and females.

Results:
Of the 366 Emirati nationals who were tested for autoimmune thyroiditis, 220 (60%) had an abnormal result for TPOAb and/or TgAb. Among the 220 patients who had an abnormal result for TPOAb and/or TgAb, 188 (85.5%) were females, and 100 patients (45.5%) were in the age group between 31 and 40 years. 42% were in a euthyroid state and 42% presented with hypothyroidism. Only 7% presented with hyperthyroidism, 5% with subclinical hypothyroidism, and 2% with subclinical hyperthyroidism. An analysis of the comorbidity factors revealed that 142 (65%) patients with obesity, 82 (37%) with a family history of thyroid disease, 77 (35%) with hyperlipidemia, 14 (6%) with hypertension, and 11 (5%) with diabetes.

Conclusion:
This is the first publication intended to address AITD in Emirati citizens. Our findings concur with the international data regarding the prevalence among middle-aged females. Eighty-four percent of the positive patients either presented with no abnormality of their thyroid gland function or with hypothyroidism. With the alarming increase of obesity in the UAE, we found it to be the single most important and preventable comorbidity factor present in 65% of the studied population. This is followed by a family history of first-degree relatives with thyroid disease in 37% of the participants, due to the high rate of consanguineous marriages in the UAE.
Role of Th17 and IL-17 Cytokines on Inflammatory and Auto-immune Diseases
Authors: Akhter Saima , Tasnim Farhin Muntaha , Islam Mohammad Nazmul , Rauf Abdur , Mitra Saikat , Emran Talha Bin , Alhumaydhi Fahad A. , Ahmed Khalil Anees , Aljohani Abdullah S.M. , Al Abdulmonem Waleed , Thiruvengadam Muthu 
Published: September 2023

Background:
The IL-17 (interleukin 17) family consists of six structurally related pro-inflammatory
cytokines, namely IL-17A to IL-17F. These cytokines have garnered significant scientific interest due to their
pivotal role in the pathogenesis of various diseases. Notably, a specific subset of T-cells expresses IL-17 family
members, highlighting their importance in immune responses against microbial infections.

Introduction:
IL-17 cytokines play a critical role in host defense mechanisms by inducing cytokines and chemokines,
recruiting neutrophils, modifying T-cell differentiation, and stimulating the production of antimicrobial
proteins. Maintaining an appropriate balance of IL-17 is vital for overall health. However, dysregulated production
of IL-17A and other members can lead to the pathogenesis of numerous inflammatory and autoimmune
diseases.

Methods:
This review provides a comprehensive overview of the IL-17 family and its involvement in several
inflammatory and autoimmune diseases. Relevant literature and research studies were analyzed to compile the
data presented in this review.

Results:
IL-17 cytokines, particularly IL-17A, have been implicated in the development of various inflammatory
and autoimmune disorders, including multiple sclerosis, Hashimoto's thyroiditis, systemic lupus erythematosus,
pyoderma gangrenosum, autoimmune hepatic disorders, rheumatoid arthritis, psoriasis, psoriatic arthritis,
ankylosing spondylitis, osteoarthritis, and graft-versus-host disease. Understanding the role of IL-17 in these
diseases is crucial for developing targeted therapeutic strategies.

Conclusion:
The significant involvement of IL-17 cytokines in inflammatory and autoimmune diseases underscores
their potential as therapeutic targets. Current treatments utilizing antibodies against IL-17 cytokines and
IL-17RA receptors have shown promise in managing these conditions. This review consolidates the understanding
of IL-17 family members and their roles, providing valuable insights for the development of novel immunomodulators
to effectively treat inflammatory and autoimmune diseases.
Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?
Authors: Negah Sajad Sahab , Forouzanfar Fatemeh 
Published: September 2023

:
The biochemical integrity of the brain is critical in maintaining normal central
nervous system (CNS) functions. One of the factors that plays an important role in
causing biochemical impairment of the brain is known as oxidative stress. Oxidative
stress is generally defined as the excessive formation of free radicals relative to
antioxidant defenses. The brain is particularly susceptible to oxidative stress because of
its high oxygen consumption and lipid-rich content. Therefore, oxidative stress damage
is associated with abnormal CNS function. Psychiatric disorders are debilitating
diseases. The underlying pathophysiology of psychiatric disorders is poorly defined and
may involve the interplay of numerous clinical factors and mechanistic mechanisms.
Considerable evidence suggests that oxidative stress plays a complex role in several
neuropsychiatric disorders, including anxiety, bipolar disorder, depression, obsessivecompulsive
disorder, panic disorder, and schizophrenia. To address these issues, we
reviewed the literature and considered the role of oxidative stress as one of the first
pathological changes in the course of neuropsychiatric disorders, which should receive
more attention in future research.
Bone Marrow Mesenchymal Stem Cell Exosomal miR-345-3p Ameliorates Cerebral Ischemia-reperfusion Injury by Targeting TRAF6
Authors: Hou Dan , Zhang Lei , Hu Yujie , Yang Guoshuai , Yu Dan 
Published: September 2023

Introduction:
The purpose of this study was to investigate the effects of bone marrow
mesenchymal stem cells (BMSCs) exosomal miR-345-3p and tumor necrosis factor receptorassociated
factor 6 (TRAF6) on cerebral ischemia reperfusion (CIR) injury. Exosomes (Exos) derived
from BMSCs were isolated and identified. PC12 (rat pheochromocytoma) cells were used to
establish an oxygen and glucose deprivation/reoxygenation (OGD/R) model.

Methods:
Cell counting kit-8, TUNEL staining, lactate dehydrogenase staining, RT-qPCR, and
western blotting were utilized for analyzing the functions of miR-345-3p about PC12 cells. Dualluciferase
reporter experiment was then to confirm the link between miR-345-3p and TRAF6. Finally,
using male SD rats, the middle cerebral artery occlusion (MCAO) model was constructed.
Regulation of I/R damage in MCAO rats of miR-345-3p and TRAF6 were further explored in the
changes of modified neurological severity score, cerebral infarction pictures, relative infarct volume,
and histopathological changes. After OGD/R treatment, neuronal apoptosis was dramatically
increased. After treatment with exosomal miR-345-3p, OGD/R-induced neuroapoptosis was dramatically
inhibited. Exosomal miR-345-3p inhibited OGD/R-induced neuroapoptosis by downregulating
the expression of TRAF6. However, the miR-345-3p inhibitor aggravated the changes
caused by OGD/R.

Results:
The corresponding regulations of miR-345-3p were reversed with TRAF6 overexpression.
The animal experiments in vivo further verified that miR-345-3p ameliorated brain I/R injury in
MCAO rats by targeting TRAF6.

Conclusion:
This study found that BMSCs-exosomal miR-345-3p protected against CIR injury by
decreasing TRAF6.
The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized,
Double-blind Clinical Trial
Authors: Irani Parichehr Sabaghzadeh , Ranjbar Hadi , Mehdipour-Rabori Roghayeh , Torkaman Mahya , Amirsalari Sudabeh , Alazmani-Noodeh Farshid 
Published: September 2023

Background:
Diabetic foot ulcer (DFU) is a prevalent complication of diabetes that can result
in severe consequences. The cost of treating DFUs is high, and there is a lack of new therapies
available in developing countries. This has created a demand for complementary and alternative
treatments. The objective of this study was to assess the impact of aloe vera gel on the healing process
of diabetic foot ulcers.

Methods and Materials:
The study was a double-blind, randomized, controlled clinical trial. The
study samples were 66 patients with diabetic foot ulcers who were randomly assigned to two groups
(intervention and control). All ulcers in both groups were washed with normal saline and dressed in
sterile gauze. The ulcers in the intervention group were covered with a thin layer of Aloe Vera gel before
the dressing. The Bates-Jensen Wound Assessment Tool (BWAT) was used on three occasions,
including before the intervention period and at the end of each week. Data were analyzed using SPSS
16.

Results:
After three weeks, there was a notable contrast in the recovery pattern of the two groups. The
patients who had aloe vera gel added to their dressing showed a more substantial decrease in the mean
scores of their BWAT.

Conclusion:
These findings are promising and suggest that Aloe vera may be a safe and effective adjunctive
treatment for diabetic foot ulcers. However, further research is needed to confirm these results
and to investigate the underlying mechanisms of aloe vera's therapeutic effect on diabetic foot ulcers.
Design, Synthesis, QSAR Studies, and Molecular Modeling of Some Novel
Bis Methyl 2-[3-(benzo[d]thiazol-2-yl)-2-terephthaloyl-bis-4-oxo-thiazolidin-
5-ylidene]acetates and Screening of their Antioxidant and Enzyme Inhibition Properties
Authors: Naseem Muhammad , Rafique Hummera , Tayyab Muhammad , Saeed Aamer , Mumtaz Amara 
Published: September 2023

Introduction:
Benzothiazolamine-based bisthiourea precursors were prepared in good yields. These bisthiourea derivatives were cyclized into symmetrical Bis Methyl 2-[3-(benzothia-zol-2-yl)-2-terephthaloyl-bis-4-oxo-thiazolidin-5-ylidene]acetates, by their condensation with (DMAD) dimethyl but-2-meditate in the presence of dry methanol.

Materials and Methods:
All these compounds were evaluated for their biological applications. An-tioxidant activities were performed by adopting a DPPH radical assay, and an in vitro enzyme in-hibition assay was performed to investigate their enzyme inhibitory potential against butyrylcholin-esterase (BChE) and acetylcholinesterase (AChE).

Results:
Molecular modeling and QSAR studies were performed to monitor the binding propensity of imidathiazolidinone derivatives with enzymes and DNA. Also, electronic and steric descriptors were calculated to determine the effect of structure on the activity of imidathiazolidinone deriva-tives.

Conclusion:
The characterization of all the synthesized compounds was done by their physical data, FT-IR, NMR and elemental analysis.
The Role of MRI in Diagnosing Agenesis of the Corpus Callosum (ACC): A
Rare Disorder Present at Birth
Authors: Alkurim Alhassan , Alyami Jaber , Aldusary Njoud , Alahmadi Adnan 
Published: September 2023

Background:
Agenesis of the corpus callosum (ACC) is a rare hereditary nervous system defect present at birth. ACC is an uncommon condition that is unrepresentative in the general population because some cases do not present with any identifiable symptoms in the early stage.

Case Report:
We present a case of ACC in a two-month-old male patient who was diagnosed after birth. Although the initial brain ultrasound (US) showed dilation of the lateral ventricles and the absence of the corpus callosum, these findings were not fully confirmed. Therefore, magnetic resonance imaging (MRI) of the brain was conducted to confirm the complex diagnosis, and the examination revealed complete ACC. Diagnosing ACC in a neonate demonstrates the complexity of diagnosis through the clinical presentation, especially at an early age.

Conclusion:
The clinical utility of neonatal US and MRI highlights the importance of an early diagnosis of ACC. MRI is more effective than the US in detecting this condition, and these imaging modalities provide the patient with an early diagnosis, which helps in treatment management.
Interactions Between Antimicrobial Peptides and Targets Responsible for
their Nephrotoxic Action: Molecular Dynamics Simulations
Authors: Lisnyak Yury , Martynov Artur , Farber Boris 
Published: September 2023

Objectives:
Polymyxin is the last line of defense against resistant forms of microorganisms,
but it has significant nephrotoxicity. One of the directions in reducing the nephrotoxicity of
polymyxin is to modify the charge of the molecule and accordingly, to change the topicity of the
polymyxin derivative to the renal megalin. Such modification can lead to a decrease in the accumulation
of polymyxin in the kidneys and reduce its toxicity while maintaining its antimicrobial properties.
The study aimed to investigate the structural aspects of polymyxin nephrotoxicity at the
atomic level to promote the more purposeful development of the polymyxin’s derivatives with the
lower nephrotoxic action.

Materials and methods:
The molecular dynamics simulations of the complexes of polymyxin B
and its derivative NAB7061 (that carries only three positive charges located within the
macrocycle) with megalin were performed in program package YASARA structure with explicit
water (TIP3P) and ions (0.9 % NaCl) in NPT ensemble using the AMRER03 force field. After 10
ns equilibration, each system was simulated at 298 K and pH 7.4 for a 25 ns production phase.
Simulations were run twice for each molecular system.

Results:
By molecular dynamics simulations, the possibility was shown for polymyxin to form a
stable complex with two neighbor structural domains of megalin in accord with the universal
mechanism of binding the cationic ligands by ligand-binding CR repeats of the LDLR-family
receptors. It was reported that interactions of megalin with polymyxin were stronger than with its
derivative having no positively charged groups outside the macrocycle. The structural prerequisites
of these differences were revealed, explaining the less nephrotoxicity of such derivatives compared
to polymyxin.

Conclusion:
Comparative molecular dynamics simulations of megalin interactions with polymyxin
B and its derivative NAB7061, which carries no positive charges outside the macrocycle, revealed
the possible structural prerequisites for the lower nephrotoxic action of such polymyxin derivatives.
The weakening of polymyxins binding with megalin may become an effective preventive
measure against polymyxin-induced nephrotoxicity.