bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of the accessibility, acceptability, safety, efficiency, clinical effectiveness, and cost-effectiveness of private cataract and orthopedic surgery clinics
Authors: Akpinar Ilke , Kirwin Erin , Tjosvold Lisa , Chojecki Dagmara , Round Jeff 
Published: August 2023

Abstract

Objectives
Many publicly funded health systems use a mix of privately and publicly operated providers of care to deliver elective surgical services. The aim of this systematic review was to assess the role of privately operated but publicly funded provision of surgical services for adult patients who had cataract or orthopedic surgery within publicly funded health systems in high-income countries.

Methods
Electronic databases (Ovid MEDLINE, OVID Embase, and EBSCO EconLit) were searched on 26 March 2021, and gray literature sources were searched on 6 April 2021. Two reviewers independently applied inclusion and exclusion criteria to identify studies, and extracted data. The outcomes evaluated include accessibility, acceptability, safety, clinical effectiveness, efficiency, and cost/cost-effectiveness.

Results
Twenty-nine primary studies met the inclusion criteria and were synthesized narratively. We found mixed results across each of our reported outcomes. Wait times were shorter for patients treated in private facilities. There was evidence that some private facilities cherry-pick or cream-skim by selecting less complex patients, which increases the postoperative length of stay and costs for public facilities, restricts access to private facilities for certain groups of patients, and increases inequality within the health system. Seven studies found improved safety outcomes in private facilities, noting that private patients had a lower preoperative risk of complications. Only two studies reported cost and cost-effectiveness outcomes. One costing study concluded that private facilities’ costs were lower than those of public facilities, and a cost–utility study showed that private contracting to reduce public waiting times for joint replacement was cost-effective.

Conclusions
Limited evidence exists that private-sector contracts address existing healthcare delivery problems. Value for money also remains to be evaluated properly.
The Role of Social Work for Emergency Medical Services (EMS): A Systematic Review
Authors: Kamrujjaman MD , Demetriou Christiana , Cuartas Álvarez Tatiana , Castro Delgado Rafael 
Published: August 2023

AbstractIntroduction:Emergency Medical Services (EMS) are integrated services involving doctors, paramedics, nurses, and social workers. This research was carried out to synthesize the evidence concerning social work roles for EMS. The aim of this study was to synthesize literature on the social worker’s role in EMS settings.Methods:The study was a systematic review. Data were collected through selected databases. The researcher used Scopus, Sociology Database, Social Science Database, and Public Health Database related to EMS and social work settings. English papers were selected, without restrictions on publication time, place, and year. The searched keywords were: “Social Work AND Emergency Medical Services AND Ambulance Services,” “Social Worker AND Emergency Medical Systems AND Ambulance Services,” “Social Work AND EMS,” “Social Worker AND EMS,” “Social Work OR Social Worker,” “Social Work Role AND EMS,” Social Worker AND EMS,” “Emergency Medical Services OR/AND Emergency Medical Systems.”Results:The study synthesized the literature about the social work role in pre-EMS, during emergency, and post-EMS. The following themes were highlighted: social workers act as cultural liaisons, effective communicators, emergency workers, and mental health practitioners, collaborating with other disciplines and researchers, for this study. In pre-emergency stages, social workers have roles as educators, communicators, advocates, and awareness builders. During an emergency, social workers act as search and rescue workers, advocates, facilitators, networkers, psychosocial assessors, consultants, counselors, and liaisons for referral activities. And in the post-emergency period, social workers have roles as planners, liaisons, interdisciplinary collaborators, researchers, evaluators, and individuals responsible for follow up.Conclusion:This study synthesizes the roles of social workers in EMS settings. It is the first study on this topic, aiming to produce new knowledge, evidence, and an EMS practice framework for the social worker.
Reliability of urine drug testing among patients on buprenorphine transdermal patch
Authors: Amaram-Davila Jaya , Reddy Akhila , Clark Matthew D. , Nancherla Anita , Arthur Joseph , Bruera Eduardo 
Published: August 2023

AbstractBackgroundUrine drug testing (UDT) plays a significant role in monitoring patients on chronic opioid therapy (COT) for non-medical opioid use (NMOU). UDT, at times, can be inconsistent and misleading. We present a case where a patient on a buprenorphine patch had false negative results.Case descriptionA female in her 70s with metastatic breast cancer presented with uncontrolled pain from a T6 compression fracture. She had no relief with tramadol 50 mg every 6 hours as needed. Due to an allergic reaction to hydromorphone, our team prescribed a buprenorphine patch of 5 μg/h. Subsequently, she expressed excellent pain control, and the clinician confirmed the patch placement on examination. She underwent a UDT during the visit. The UDT was negative for both buprenorphine and its metabolites. The literature review showed that false negative UDT results are relatively common among patients with low-dose buprenorphine patches. The combination of a thorough physical examination, a review of the Prescription Drug Monitoring Program, and reassuring scores on screening tools placed her at low risk for NMOU.DiscussionBuprenorphine has a ceiling effect on respiratory depression and a lower risk for addiction. However, when used in low doses, the drug might not have enough metabolites in the urine, leading to a false negative UDT. Such results might affect patient–physician relationships.ConclusionIn addition to the UDT, a thorough history, screening for NMOU, physical exam, a review of PDMP, and a good understanding of opioid metabolism are necessary to help guide pain management.
Frequency of vaccine hesitancy among patients with advanced cancer
Authors: Tang Michael , Heung Yvonne , Fellman Bryan , Bruera Eduardo 
Published: August 2023

AbstractBackgroundVaccine hesitancy has become prevalent in society. Vulnerable populations, such as those with cancer, are susceptible to increased morbidity and mortality from diseases that may have been prevented through vaccination.ObjectivesOur objective was to determine patient perception of vaccine efficacy and safety and sources of information that influence decisions.MethodsThis study was a prospective cross-sectional survey trial conducted from March 10, 2022, to November 1, 2022, at a Supportive Care Clinic. Patients completed the survey with a research assistant or from a survey link. Vaccine hesitancy was defined as a response of 2 or more on the Parent Attitudes About Childhood Vaccines (PACV-4). Perception on vaccine safety and efficacy along with the importance of sources of information were determined by a questionnaire.ResultsOf the 72 patients who completed the PACV-4, 30 were considered vaccine-hesitant (42%). Of those who completed the survey alone (35), 23 (66%) were vaccine-hesitant; and of those who completed the survey with the help of a study coordinator (37), 7 (19%) were vaccine-hesitant. The most important source for decision-making was their doctor (82%, 95% CI 73–89), followed by family (42%, 95% CI 32–52), news/media (31%, 95% CI 22–41), and social media (9%, 95% CI 4–16). Clinical and demographic factors including age, gender, race/ethnicity, education level, and location of residence were not associated with vaccine hesitancy.Significance of resultsVaccine hesitancy is present among patients with advanced cancer. The high value given to the doctor’s recommendation suggests that universal precautions regarding vaccine recommendation may be an effective intervention.
Future Projections of Extreme Integrated Water Vapor Transport and Population Exposure Over the Asian Monsoon Region
Authors: Guo Lianyi , Shi Yi , Zhao Yang 
Published: August 2023

AbstractGlobal warming leads to an intensification of the water cycle and an increase in extreme climate events. Most previous researchers have used precipitation to project extreme hydrological changes. However, compared with precipitation, global climate models (GCMs) have a better performance in simulating the integrated vapor transport (IVT). IVT is thus a reliable tool for understanding how hydrological extremes may change in the future. In this study, we first discuss the relationship between IVT and precipitation over the Asian monsoon (AM) region during 1979–2014. We then assess the climatology, variability and extremes of IVT over the AM region and subregions using 16 GCMs from CMIP6. We further apply GCMs to project changes in the magnitude and probability of dangerous extreme IVT events (e.g., 20‐, 50‐ and 100‐year events) in the future. Finally, we quantify the population exposure to extreme IVT events, and explain change in exposure and its uncertainty. Results show that CMIP6 GCMs capture the spatial distribution of IVT well; the intensity of simulated IVT is lower than the ERA5 IVT. Under global warming of 1.5, 2, and 3°C, the magnitude of extreme events, which is independent of the return period (RP), increases over the AM region with relative changes of about 7%, 12%, and 21%, respectively. The probability increases consistently with global warming and the RP. The increase in exposure for the South Asian monsoon (East Asian monsoon) region is both contributed by more extreme IVT events and higher (fewer) population counts; the former has a larger proportion.
Weddell Sea Control of Ocean Temperature Variability on the Western Antarctic Peninsula
Authors: Morrison Adele K. , England Matthew H. , Hogg Andrew McC. , Kiss Andrew E. 
Published: August 2023

AbstractRecent ice loss on the western Antarctic Peninsula has been driven by warming ocean waters on the continental shelf. However, due to the short observational record, our understanding of the dynamics and variability in this region remains poor. High‐resolution ocean model simulations show that the temperature variability along the western Antarctic Peninsula is controlled by the rate of dense water formation in the Weddell Sea. Passive tracer advection reveals connectivity between the Weddell Sea and the coastline of the western Antarctic Peninsula and Bellingshausen Sea. During multi‐year periods of weak Weddell dense water formation, dense overflow transport in the Weddell Sea decreases, while the transport of cold water around the tip of the Antarctic Peninsula strengthens, driving a temperature decrease of 0.4°C along the western Antarctic Peninsula. This mechanism implies that western Antarctic Peninsula coastal ocean temperature may cool in the future if Weddell Dense Shelf Water production slows down.
The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis
Authors: Lee Soo Yeon , Park Soo-Yeon , Lee Seung-Hyun , Kim Hyunsik , Kwon Jae-Hwan , Yoo Jung-Yoon , Kim Kyunggon , Park Moo Suk , Lee Chun Geun , Elias Jack A. , Sohn Myung Hyun , Shim Hyo Sup , Yoon Ho-Geun 
Published: August 2023

AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic, fatal, fibrotic, interstitial lung disease of unknown cause. Despite extensive studies, the underlying mechanisms of IPF development remain unknown. Here, we found that p300 was upregulated in multiple epithelial cells in lung samples from patients with IPF and mouse models of lung fibrosis. Lung fibrosis was significantly diminished by the alveolar type II (ATII) cell–specific deletion of the p300 gene. Moreover, we found that ubiquitin C-terminal hydrolase L3 (UCHL3)-mediated deubiquitination of p300 led to the transcriptional activation of the chemokines Ccl2, Ccl7, and Ccl12 through the cooperative action of p300 and C/EBPβ, which consequently promoted M2 macrophage polarization. Selective blockade of p300 activity in ATII cells resulted in the reprogramming of M2 macrophages into antifibrotic macrophages. These findings demonstrate a pivotal role for p300 in the development of lung fibrosis and suggest that p300 could serve as a promising target for IPF treatment.
Unveiling the lamellar structure of the human cornea over its full thickness using polarization-resolved SHG microscopy
Authors: Raoux Clothilde , Chessel Anatole , Mahou Pierre , Latour Gaël , Schanne-Klein Marie-Claire 
Published: August 2023

AbstractA key property of the human cornea is to maintain its curvature and consequently its refraction capability despite daily changes in intraocular pressure. This is closely related to the multiscale structure of the corneal stroma, which consists of 1–3 µm-thick stacked lamellae made of thin collagen fibrils. Nevertheless, the distribution, size, and orientation of these lamellae along the depth of the cornea are poorly characterized up to now. In this study, we use second harmonic generation (SHG) microscopy to visualize the collagen distribution over the full depth of 10 intact and unstained human corneas (500–600 µm thick). We take advantage of the small coherence length in epi-detection to axially resolve the lamellae while maintaining the corneal physiological curvature. Moreover, as raw epi-detected SHG images are spatially homogenous because of the sub-wavelength size of stromal collagen fibrils, we use a polarimetric approach to measure the collagen orientation in every voxel. After a careful validation of this approach, we show that the collagen lamellae (i) are mostly oriented along the inferior–superior axis in the anterior stroma and along the nasal-temporal axis in the posterior stroma, with a gradual shift in between and (ii) exhibit more disorder in the anterior stroma. These results represent the first quantitative characterization of the lamellar structure of the human cornea continuously along its entire thickness with micrometric resolution. It also shows the unique potential of P-SHG microscopy for imaging of collagen distribution in thick dense tissues.
Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
Authors: Cui Yange , Wang Luyang , Ding Qingbao , Shin Jihae , Cassel Joel , Liu Qin , Salvino Joseph M. , Tian Bin 
Published: August 2023

AbstractCleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic poly(A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73, is the first known CPA inhibitor (CPAi) in mammalian cells. Here we show that JTE-607 perturbs gene expression through both transcriptional readthrough and alternative polyadenylation (APA). Sensitive genes are associated with features similar to those previously identified for PCF11 knockdown, underscoring a unified transcriptomic signature of CPAi. The degree of inhibition of an APA site by JTE-607 correlates with its usage level and, consistently, cells with elevated CPA activities, such as those with induced overexpression of FIP1, display greater transcriptomic disturbances when treated with JTE-607. Moreover, JTE-607 causes S phase crisis and is hence synergistic with inhibitors of DNA damage repair pathways. Together, our data reveal CPA activity and proliferation rate as determinants of CPAi-mediated cell death, raising the possibility of using CPAi as an adjunct therapy to suppress certain cancers.
Incandescent temporal metamaterials
Authors: Vázquez-Lozano J. Enrique , Liberal Iñigo 
Published: August 2023

AbstractRegarded as a promising alternative to spatially shaping matter, time-varying media can be seized to control and manipulate wave phenomena, including thermal radiation. Here, based upon the framework of macroscopic quantum electrodynamics, we elaborate a comprehensive quantum theoretical formulation that lies the basis for investigating thermal emission effects in time-modulated media. Our theory unveils unique physical features brought about by time-varying media: nontrivial correlations between fluctuating electromagnetic currents at different frequencies and positions, thermal radiation overcoming the black-body spectrum, and quantum vacuum amplification effects at finite temperature. We illustrate how these features lead to striking phenomena and innovative thermal emitters, specifically, showing that the time-modulation releases strong field fluctuations confined within epsilon-near-zero (ENZ) bodies, and that, in turn, it enables a narrowband (partially coherent) emission spanning the whole range of wavevectors, from near to far-field regimes.
TRIM28 modulates nuclear receptor signaling to regulate uterine function
Authors: Li Rong , Wang Tianyuan , Marquardt Ryan M. , Lydon John P. , Wu San-Pin , DeMayo Francesco J. 
Published: August 2023

AbstractEstrogen and progesterone, acting through their cognate receptors the estrogen receptor α (ERα) and the progesterone receptor (PR) respectively, regulate uterine biology. Using rapid immunoprecipitation and mass spectrometry (RIME) and co-immunoprecipitation, we identified TRIM28 (Tripartite motif containing 28) as a protein which complexes with ERα and PR in the regulation of uterine function. Impairment of TRIM28 expression results in the inability of the uterus to support early pregnancy through altered PR and ERα action in the uterine epithelium and stroma by suppressing PR and ERα chromatin binding. Furthermore, TRIM28 ablation in PR-expressing uterine cells results in the enrichment of a subset of TRIM28 positive and PR negative pericytes and epithelial cells with progenitor potential. In summary, our study reveals the important roles of TRIM28 in regulating endometrial cell composition and function in women, and also implies its critical functions in other hormone regulated systems.
A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans
Authors: Zhang Wencheng , Wang Xicheng , Lanzoni Giacomo , Wauthier Eliane , Simpson Sean , Ezzell Jennifer Ashley , Allen Amanda , Suitt Carolyn , Krolik Jonah , Jhirad Alexander , Dominguez-Bendala Juan , Cardinale Vincenzo , Alvaro Domenico , Overi Diletta , Gaudio Eugenio , Sethupathy Praveen , Carpino Guido , Adin Christopher , Piedrahita Jorge A , Mathews Kyle , He Zhiying , Reid Lola McAdams 
Published: August 2023

AbstractA network of co-hepato/pancreatic stem/progenitors exists in pigs and humans in Brunner’s Glands in the submucosa of the duodenum, in peribiliary glands (PBGs) of intrahepatic and extrahepatic biliary trees, and in pancreatic duct glands (PDGs) of intrapancreatic biliary trees, collectively supporting hepatic and pancreatic regeneration postnatally. The network is found in humans postnatally throughout life and, so far, has been demonstrated in pigs postnatally at least through to young adulthood. These stem/progenitors in vivo in pigs are in highest numbers in Brunner’s Glands and in PDGs nearest the duodenum, and in humans are in Brunner’s Glands and in PBGs in the hepato/pancreatic common duct, a duct missing postnatally in pigs. Elsewhere in PDGs in pigs and in all PDGs in humans are only committed unipotent or bipotent progenitors. Stem/progenitors have genetic signatures in liver/pancreas-related RNA-seq data based on correlation, hierarchical clustering, differential gene expression and principal component analyses (PCA). Gene expression includes representative traits of pluripotency genes (SOX2, OCT4), endodermal transcription factors (e.g. SOX9, SOX17, PDX1), other stem cell traits (e.g. NCAM, CD44, sodium iodide symporter or NIS), and proliferation biomarkers (Ki67). Hepato/pancreatic multipotentiality was demonstrated by the stem/progenitors’ responses under distinct ex vivo conditions or in vivo when patch grafted as organoids onto the liver versus the pancreas. Therefore, pigs are logical hosts for translational/preclinical studies for cell therapies with these stem/progenitors for hepatic and pancreatic dysfunctions.
Endovascular treatment in bilateral cavernous sinus dural arteriovenous fistulas: a systematic review and meta-analysis
Authors: Perng Pang-Shuo , Chang Yu , Sun Yuan-Ting , Wang Hao-Kuang , Jiang Yu-Shu , Lee Jung-Shun , Wang Liang-Chao , Huang Chih-Yuan 
Published: August 2023

AbstractFew studies have discussed the disease nature and treatment outcomes for bilateral cavernous sinus dural arteriovenous fistula (CSDAVF). This study aimed to investigate the clinical features and treatment outcomes of bilateral CSDAVF. Embase, Medline, and Cochrane library were searched for studies that specified the outcomes of bilateral CSDAVF from inception to April 2022. The classification, clinical presentation, angiographic feature, surgical approach, and treatment outcomes were collected. Meta-analysis was performed using the random effects model. Eight studies reporting 97 patients were included. The clinical presentation was mainly orbital (n = 80), cavernous (n = 52) and cerebral (n = 5) symptoms. The most approached surgical route was inferior petrosal sinus (n = 80), followed by superior orbital vein (n = 10), and alternative approach (n = 7). Clinical symptoms of 88% of the patients (95% CI 80–93%, I2 = 0%) were cured, and 82% (95% CI 70–90%, I2 = 7%) had angiographic complete obliteration of fistulas during follow up. The overall complication rate was 18% (95% CI 11–27%, I2 = 0%). Therefore, endovascular treatment is an effective treatment for bilateral CSDAVF regarding clinical or angiographic outcomes. However, detailed evaluation of preoperative images and comprehensive surgical planning of the approach route are mandatory owing to complexity of the lesions.
TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways
Authors: Singh Karnika , Han Chunhua , Fleming Jessica L. , Becker Aline P. , McElroy Joseph , Cui Tiantian , Johnson Benjamin , Kumar Ashok , Sebastian Ebin , Showalter Christian A. , Schrock Morgan S. , Summers Matthew K. , Becker Valesio , Tong Zhen-yue , Meng Xiaomei , Manring Heather R. , Venere Monica , Bell Erica H. , Robe Pierre A. , Grosu A. L. , Haque S. Jaharul , Chakravarti Arnab 
Published: August 2023

AbstractGBM (Glioblastoma) is the most lethal CNS (Central nervous system) tumor in adults, which inevitably develops resistance to standard treatments leading to recurrence and mortality. TRIB1 is a serine/threonine pseudokinase which functions as a scaffold platform that initiates degradation of its substrates like C/EBPα through the ubiquitin proteasome system and also activates MEK and Akt signaling. We found that increased TRIB1 gene expression associated with worse overall survival of GBM patients across multiple cohorts. Importantly, overexpression of TRIB1 decreased RT/TMZ (radiation therapy/temozolomide)-induced apoptosis in patient derived GBM cell lines in vitro. TRIB1 directly bound to MEK and Akt and increased ERK and Akt phosphorylation/activation. We also found that TRIB1 protein expression was maximal during G2/M transition of cell cycle in GBM cells. Furthermore, TRIB1 bound directly to HDAC1 and p53. Importantly, mice bearing TRIB1 overexpressing tumors had worse overall survival. Collectively, these data suggest that TRIB1 induces resistance of GBM cells to RT/TMZ treatments by activating the cell proliferation and survival pathways thus providing an opportunity for developing new targeted therapeutics.