bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Overlapping Targets of Shh and Gata3 during Craniofacial Development
Authors: Kar Ranjeet D. , Eberhart Johann K. 
Published: June 2023

Abstract
Background
Congenital birth defects are among the leading causes of infant mortality. Phenotypic variation in these defects results from a combination of genetic and environmental factors. One example of this is the modulation of palate phenotypes caused by mutation of the transcription factor Gata3 via the Sonic hedgehog (Shh) pathway. We exposed zebrafish to a subteratogenic dose of the Shh antagonist cyclopamine, and another group to both cyclopamine and gata3 knockdown. We performed RNA-seq on these zebrafish to characterize the overlap of Shh and Gata3 targets.
Results
We examined those genes whose expression patterns mirrored the biological effect of exacerbated misregulation. These genes were not significantly misregulated by the subteratogenic dose of ethanol but more misregulated by combinatorial disruption of Shh and Gata3 relative to Gata3 alone. Using gene-disease association discovery, we were able to refine this gene list to 11 that have published links to clinical outcomes similar to the gata3 phenotype or with craniofacial malformations. We also used weighted gene co-expression network analysis to identify a module of genes that correlate strongly with co-regulation by Shh and Gata3. This module is enriched in genes related to Wnt signaling.
Conclusions
We found numerous differentially expressed genes in response to cyclopamine treatment, and even more from double treatment. Most notably, we found a group of genes whose expression profile mirrored the biological effect of Shh/Gata3 interaction. Pathway analysis implicated the importance of Wnt signaling in Gata3/Shh interactions in palate development.
RNA-Seq Transcriptome Profiling of Immature Grain Wheat: A Comparative Modeling of Baking Quality
Authors: Ahmadi-Ochtapeh Hossein , Soltanloo Hassan , Ramezanpour Seyyede Sanaz , Yamchi Ahad , Shariati Vahid 
Published: June 2023

Abstract
Improving the baking quality is a primary challenge in the wheat flour production value chain, as baking quality represents a crucial factor in determining its overall value. In the present study, we conducted a comparative RNA-Seq analysis on the high baking quality mutant “O-64.1.10” genotype and its low baking quality wild type "Omid" cultivar to recognize potential genes associated with bread quality. The cDNA libraries were constructed from immature grains that were 15 days post-anthesis (DPA), with an average of 16.24 and 18.97 million PE short-read sequences in the mutant and wild-type, respectively. A total number of 733 transcripts with differential expression were identified, 584 and 189 of which were obtained with significantly differentially expressed genes (DEGs) in the mutant and the wild-type, respectively. In addition, the families of HSF, bZIP, C2C2-Dof, B3-ARF, BES1, C3H, GRF, HB-HD-ZIP, PLATZ, MADS-MIKC, GARP-G2-like, NAC, OFP and TUB were appeared as the key transcription factors with specific expression in the “O-64.1.10” genotype. At the same time, pathways related to baking quality were identified through Kyoto Encyclopedia of Genes and Genomes (KEGG). Collectively, we found that the endoplasmic network, metabolic pathways, secondary metabolite biosynthesis, hormone signaling pathway, B group vitamins, protein pathways, pathways associated with carbohydrate and fat metabolism, as well as the biosynthesis and metabolism of various amino acids, have a great deal of potential to play a significant role in the baking quality. Ultimately, the RNA-seq results were confirmed using qRT-PCR for some hub genes such as alpha-gliadin, Low molecular weight glutenin subunit (LMW-GS) and terpene synthase (gibberellin) and as a resource for future study, 127 EST-SSR primers were generated using RNA-seq data.
Comparative Evaluation Of Tapentadol And Tramadol In Reducing Pain Mandibular Third Molar Surgery
Authors: Magoo Surabhi , Bhate Kalyani , Kakodkar Pradnya , Kshirsagar Kapil , Magoo Simran 
Published: June 2023

Abstract
Objective: This study was carried out to compare the analgesic efficiency of Tapentadol against Tramadol after surgical removal of mandibular third molar.
Methods: This was a prospective, triple-blind, split mouth, cross-over study conducted on 24 patients requiring bilateral surgical removal of mandibular third molar with similar difficulty index under local anesthesia. Group A [n=24] represented Tapentadol and Group B [n=24] represented Tramadol. Pain was the outcome assessor which was recorded using the Visual Analogue Scale [VAS 0-10] on post-operative day 1 [POD1] and post-operative day 5 [POD5] respectively. 48 extraction sites were randomly assigned by simple randomization with a 1:1 allocation ratio to Tapentadol or Tramadol. The operator, co-investigator who recorded the VAS scores and the statistician were blinded. The patient enrollment and allotment was done independently by another researcher.
Results: VAS score for pain on POD1 was significantly lesser in Group A than Group B [P < 0.0001]. VAS score on POD5 showed no significant difference [P = 0.14]. The number of rescue medications required were more in Group B. No significant harm or unintended effects were observed in any of the groups at the end of the study.
Conclusion: This study showed that Tapentadol has better analgesic effect when compared with Tramadol after surgical removal of mandibular third removal.
Clinical Relevance: Hence, tapentadol could be considered as drug of choice for pain control after mandibular third molar surgery.
Quantifying the Effects of Water Management Decisions on Streambank Stability
Authors: Wei Quan , Layzell Anthony , Brookfield Andrea 
Published: June 2023

Abstract
Both natural processes and human activities alter streamflow conditions, which can significantly affect streambank erosion and stability, leading to negative consequences including sedimentation of reservoirs, contamination of streams, loss of productive land, and damage to infrastructure. Hydrological conditions, which are often controlled by water management infrastructure (e.g., reservoirs and dams) and decisions, are a major factor affecting streambank erosion and stability. While significant research has studied the relationships between hydrology and water management, as well as hydrology and streambank stability, there is little research that considers the connection between water management and streambank stability. The objective of this work is to develop a module to investigate how water management decisions, particularly reservoir operations, affect streambank stability.
A module was developed to estimate streambank stability using a factor of safety approach, with hydrologic conditions derived from an established integrated hydrologic model. This module is validated and then demonstrated using integrated hydrologic model results from the Lower Republican River Basin in Kansas, USA. Results applied to this basin indicate that several water management decisions, such as groundwater pumping and timing of reservoir releases, may negatively affect streambank stability by changing pore water pressure, the weight of the streambank soil, and the pressure differential between surface and subsurface. Given that most of the rivers and streams of the world are regulated by reservoir operations, this work demonstrates why this water management needs to be considered in simulations of streambank stability.
Analysis of Genetic Variations in NSP4 of Type 1 Porcine Reproductive and Respiratory Syndrome Virus in China
Authors: Sha Huiyang , Zhang Hang , Luo Qin , Zheng Yajie , Li Gan , Kong Weili , Huang Liangzong , Zhao Mengmeng 
Published: June 2023

Abstract
Background
Porcine reproductive and respiratory syndrome virus (PRRSV) is constantly evolving, and the detection rate of PRRSV-1 in China has been increasing annually. To investigate the prevalence and genetic variation of NSP4 in PRRSV-1 in China, 40 PRRSV whole-genomes sequences were collected and the NSP4 sequences were selected for nucleotide and amino acid homology analysis. In addition, amino acid site variation analysis was performed on the NSP4 sequences of the 40 PRRSV strains, and phylogenetic trees were constructed based on the whole-genomes and NSP4 sequences of 86 PRRSV strains.
Results
The nucleotide homology of NSP4 between 32 PRRSV-1 and 8 PRRSV-2 strains ranged from 57.3–62.4%, and the amino acid homology ranged from 58.6–64.5%. The nucleotide homology of NSP4 among the 32 PRRSV-1 strains ranged from 75.4–100.0%, and the amino acid homology ranged from 81.3–100.0%. Comparison of the NSP4 amino acid sequences of 32 PRRSV-1 and 8 PRRSV-2 strains revealed that the biggest difference was a deletion at the 83rd amino acid residue in PRRSV-1, and other differences manifested as varying degrees of mutations at multiple amino acid sites. Phylogenetic analysis showed that the PRRSV-1 strains isolated in China clustered into four subgroups of Subtype 1 Global: Amervac-like, BJEU06-1-like, HKEU16-like, and NMEU09-1-like strains.
Conclusion
PRRSV-1 NSP4 exhibits similarities to Subtype 1 Global strains and clusters into four subgroups. Although it differs from PRRSV-2 with a deletion in the 83rd amino acid residue, the catalytic triad amino acid residues are conserved. These findings have important implications for the development of secure and reliable detection methods and guide further research on PRRSV-1, providing a theoretical foundation for the development of new drugs and vaccines.
The state of metaverse research - a bibliometric visual analysis based on CiteSpace
Authors: Li Huike , Li Bo 
Published: June 2023

Abstract
Objective: To understand the current status of research in the field of metaverse, and to analyze the research progress and evolutionary trends in this field. Methods: Based on the bibliometric analysis, a total of 259 papers were obtained by searching the Web of science core database for the keyword "metaverse" after elimination. CiteSpace was used to visualize and analyze the current status and trends of metaverse research in China. Results: China is currently the country with the largest number of publications in this field. India is currently the country with the highest research impact. A research network has been formed with Nanyang Technological University as the core. More than 1/3 of the authors in the field of metaverse research are core authors, and 10 research hotspots have been formed, such as artificial intelligence and social existence. Conclusion: The current research on metaverse in various fields is basically in its infancy, but has a great potential for future development and will gradually penetrate into many different directions. [
CT features of radiation-induced lung injuries can show the prognosis after stereotactic ablative radiotherapy in early-stage non-small cell lung cancer
Authors: Wang Fang , Wang Lin , Yang Hong , chen Wujie , Ruan Lei , Xu Yujin , Jiang Haitao 
Published: June 2023

Abstract
Objective
To investigate the correlation between peritumoral radiation-induced lung injuries and prognosis of early non-small cell lung cancer after stereotactic ablative radiotherapy (SABR).
Methods
Clinical data and follow-up imaging data of patients with early NSCLC who received SABR treatment in Department of Thoracic Radiotherapy of Zhejiang Cancer Hospital from January 2012 to December 2018 were retrospectively collected, and the Progression Free Survival (PFS) was calculated. CT features of peritumoral radiation-induced lung injuries were observed by 3 radiologists with more than 10–15 years of experience. CT features of peritumoral radiation-induced lung injuries were divided into 3 types. Type 1 was diffuse consolidation around the tumor with the tumor boundary covered. Type 2 is the diffuse ground glass shadow around the tumor, which is distributed in the range of more than 180 degrees around the tumor. Type 3 is the patchy ground glass shadow surrounding the tumor within a range of less than 180 degrees. Log-rank test was used to analyze the correlation between CT features of radiation-induced lung injuries and PFS rate of NSCLC after SABR. Independent influencing factors of PFS rate were analyzed by COX multivariate regression.
Results
5-year PFS rate corresponding to CT features of peritumoral radiation-induced lung injuries 3–5 months after SABR in early lung cancer were type 1:68.1%; Type 2:73.1%; Type 3:35.3%; there was a statistical difference between the CT features of three types of peritumoral radiation-induced lung injuries (p = 0.006). The 5-year PFS rate corresponding to the CT features of peritumoral radiation-induced lung injuries 6–8 months after SABR were type 1:69.5%; Type 2:50.9%; Type 3:36.1%; there was statistical difference between the CT features of three types of peritumoral radiation-induced lung injuries (p = 0.025). COX multivariate regression analysis showed that the CT features of peritumoral radiation-induced lung injuries were independent factors influencing PFS rate (at 6–8 months follow-up after radiotherapy (p = 0.041).
Conclusions
CT features of peritumoral radiation-induced lung injuries can predict the recurrence risk of early non-small cell lung cancer after SABR, and the type of CT features at 6–8 months after SABR was an independent predictor of recurrence risk.
Colorectal Cancer Deaths in South America: time-series analysis
Authors: Correa Alvin J. H. , Freiberg Ernesto D. , Birnenbaum Silvia J. , Avancini Constanza , Popielik Nicolás A. , Regazzoni Carlos Javier 
Published: June 2023

Abstract

Background
Colorectal cancer (CRC) in South America causes 69,435 deaths annually; mortality rates are heterogeneous across countries. Limited resources in public health systems defy screening and treatment interventions, rendering forecasting and modeling invaluable policy-making tools. We aimed to forecast CRC deaths in individuals aged 55 or older in South America for the period 2020–2030 using time-series analysis and assess heterogeneity in CRC death rates.
Methods
Time-series analysis were used to forecast CRC mortality in South America in individuals aged 55 + years. ARIMA and Bayesian with Gaussian processes (GP) and Markov-Chain Montecarlo Simulation models were developed. Heterogeneity in CRC mortality rates across countries was evaluated. Data were extracted from the Global Burden of Disease study.
Results
Between 2020 and 2030, South American countries are expected to record between 680,514 (ARIMA) and 548,372 (GP) CRC deaths in individuals aged 55 or older, both sexes. Brazil and Argentina with the highest burden. The ARIMA model predicts an increase in annual deaths from 52,905 (2020) to 70,811 (2030), while the GP model predicts a slight decrease from 51,343 (2020) to 43,344 (2030). Mortality rates vary significantly between countries, with Uruguay having the highest in 2010 (236.12/100,000) followed by Argentina and Brazil.
Conclusion
Both the ARIMA and GP models predicted that more than half million people would dye of CRC in South America during the next decade. Mortality rates will be heterogeneous among countries. Accurate forecasting is essential for effective public policies. Continued research and concerted efforts are necessary to address the burden of CRC and to explain causes of varying mortality rates.
Boosting the Electron Beam Transmittance of Field Emission Cathode Using a Self-Charging Gate
Authors: Xiao Dongyang , Sun Leimeng , Du Huanhuan , Suo Xiaochen , Wang Yurong , Zhang Yili , Kuang Shuangyang , Song Peiyi 
Published: June 2023

Abstract
The gate-type carbon nanotubes (CNTs) cathodes exhibit advantages in long-term stable emission owing to the uniformity of electrical field on the CNTs, but the gate inevitably reduces the transmittance of electron beam (E-beam), posing challenges for system stabilities. In this work, we introduce an E-beam focusing technique using the self-charging SiNx/Au/Si gate. The surface potential of SiNx is measured to be approximately -60 V quickly after the cathode turning-on, the negative potential can be maintained as the emission goes on. The charged surface generates rebounding electrostatic forces on the following electrons, significantly focusing the E-beam on the center of gate hole and allowing them to pass through with minimal interceptions. An average transmittance of 96.17% is observed during a 550-hour prototype test. We believe that this high-efficiency, long-term stable cathode has great potential for using in neutralizers, solar sails and tethered satellites in the long-term space missions.
Mechanical modeling of groove rolling for heavy plate based on the weighted average yield criterion
Authors: Zhang Shun Hu , Wan Liang Wei , Zhang Yi , Chen Dong 
Published: June 2023

Abstract
A new model is constructed using the weighted average yield criterion (WA criterion) to eliminate the excessive model error in estimating the groove rolling force of a heavy plate. To this end, under the precondition of plane deformation, a two-dimensional strain rate fieldfor describing groove rolling is established in the cylindrical coordinate system. The WA criterion, replacing the Mises yield criterion (Mises criterion), is introduced to calculate the internal deformation power based on the strain rate field. The shear power and friction power are also obtained according to the shear yield condition derived from the criterion. Finally, an analytical rolling force model is established based on the variational principle. The results are compared with those by a model based on the Mises criterion and their corresponding measured ones. The model developed in this paper is proven to be more accurate than the model using the Mises criterion. Through parameter analysis, it is found that the groove rolling force is significantly affected by these parameters, such as the size of the rolled workpiece, reduction, and friction factor. The present research can serve as a scientific foundation for high-precision groove rolling control for the heavy plate.
A Prediction Methodology on b Value of Shock Event Time Series with Fully Mechanized Top-coal Caving Mining in Steeply Inclined Thick Coal Seam, Urumchi coal field, China
Authors: Shan Pengfei , Yan Zhongming , Lai Xingping , Xu Huicong , Hu Qinxin , Guo Zhongan 
Published: June 2023

Abstract
Rock burst disaster is still one of the most serious dynamic disasters in coal mining, seriously restricting the safety of coal mining. The b value is the main parameter for monitoring rock burst, and by analyzing its changing characteristics, it can effectively predict the dangerous period of rock burst. This article proposes a method based on deep learning that can predict rock burst using data generated from microseismic monitoring in underground mining. Methods Firstly, the b value is calculated from the microseismic monitoring data and a time series data set is constructed. The data set is cleaned by the complete set empirical mode decomposition algorithm (CEEMDAN), Construct a b value time series prediction model based on differential algorithm optimization for CNN-BiLSTM Attention. The study used microseismic monitoring data from B1 + 2 fully mechanized mining face and B3 − 6 working face in the southern mining area of Wudong Coal Mine for engineering case analysis. The commonly used residual sum of squares, mean square error, root mean square error, and correlation coefficient R2 for time series prediction were introduced, and compared with the basic LSTM algorithm. It was verified that the prediction method proposed in this article has good prediction effect and certain feasibility. It can provide technical support for predicting and preventing rock burst in steeply inclined thick coal seams in strong earthquake areas.
MHD Three Dimensional Rotating and Radiating Hybrid Fe 3 O 4 /Al 2 O 3 Nanofluid Flow over a Stretched Plate with Hall Current
Authors: Kodi Raghunath , Vaddemani Ramachandra Reddy , M Ijaz khan 
Published: June 2023

Abstract
Researchers prioritize the study of nanofluids because of the many applications their fast heat transfer rates make possible in the industrial sector. Recently, an innovative kind of nanofluid known as hybrid nanofluid has been used to further improve the heat transmission rate. This new model in three dimensions is used to investigate the impact of a magnetic field, joule heating, rotation parameter, and Hall current, as well as nonlinear thermal radiation, on a rotating hybrid Fe3O4/Al2O3 nanofluid over-stretched plate in the presence of a chemical reaction with thermophoresis and a Brownian motion parameter. The primary focus of this research is on the Brownian motion parameter. Similar adaptations translate the governing partial differential identification into a set of nonlinear ordinary differential identifications. The shooting technique obtains numerical solutions for that system of equations. The impact of various entry parameters on transversal and longitudinal velocities, temperature, heat flow and surface shear stress are studied numerically and graphically. It was shown that there is a strong connection between the primary research when looking at particular situations that indicate how the current technique meets the convergence requirements. In addition, the physical relevance of the contributed parameters is shown via graphs and tables. The discovery demonstrates that an increase in the particle concentration of the hybrid nanofluid accelerates the flow of the liquid. In addition, factoring in dissipative heat makes it more likely that the fluid temperature will be increased to accommodate the participation of the particle concentration.
The effect of executive managers' walk round on patient safety culture in emergency nurses
Authors: Amin Behnam , Navvabi Parisa , Salehi Narges , Javadi Mostafa 
Published: June 2023

Abstract
Background & Objective: Effective teamwork is vital in providing safe and effective patient care, especially in a high-risk setting such as the emergency ward. The culture of patient safety has a direct impact on the way work is performed and, consequently, on the safety of patients. One of the ways to promote the patient safety culture is to support the hospital's management team and improve the teamwork climate. This study was conducted with the aim of investigating the effect of executive managers' walk-round on patient safety culture in emergency ward nurses.Materials & Methods This quasi-experimental study was carried out in four emergency wards (two wards for the experimental group and two wards for the control group). From each group, 32 nurses were selected by stratified random sampling method and entered the study. For the experimental group, executive managers’ walk-round was conducted for five months. The safety culture questionnaire was completed before and after the intervention in two groups. Data were analyzed with SPSS22.Results The average scores of the patient safety culture of the two experimental and control groups were not statistically different before the intervention. Yet, the score of the experimental group was 130.44 ± 7.80 and that of the control group was 124.19 ± 8.76 after intervention, which showed a statistically significant difference (P ≤ 0.001). Besides, after intervention, the scores of "team work within hospital units" (P = 0.015), "overall perceptions of safety" (P = 0.042), "communication openness" (P = 0.020), "non-punitive response to the error" "(P = 0.001), "feedback and communication about errors" (P = 0.021), and also the total score of the questionnaire (P = 0.001) were higher in the experimental group compared to the control group.Conclusion This study provided further insight into the importance of hospital management's support in improving patient safety culture. Executive managers' walk-round increased the culture of patient safety in emergency nurses; thus, it is suggested to use the executive managers' walk-round to improve the level of patient safety and increase the quality of service to patients.