bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifractal cross‐correlation analysis between CME and Planetary K‐index time series
Authors: Chattopadhyay Anirban , Khondekar Mofazzal H. 
Published: January 2023

AbstractThis research aims to examine the multiscale‐multifractal correlation properties between the geomagnetic storm and coronal mass ejection (CME) occurrences by analyzing the CME linear speed and Planetary K‐index time series data. The relevant data for both CME and geomagnetic storm occurrences were obtained from the Solar and Heliospheric Observatory mission's LASCO and the NOAA Space Weather Prediction Center, respectively, for the same period (February 1999 to December 2007). We performed MultiFractal cross‐correlation Detrended Fluctuation Analysis (MFXDFA) and Multifractal cross‐correlation Detrending Moving average Analysis (MFXDMA) to investigate and quantify the possible cross‐correlation between the two natural events. The MFXDFA technique is also compared to the backward MFXDMA algorithm's performance. The change in the degree of cross‐correlation over time has been investigated, and the findings are quantitatively analyzed. The existence of significant power‐law cross‐correlations has been discovered within all scaling orders. Furthermore, we also find evident persistence of cross‐correlation with substantial Hurst exponents. In addition, it has been observed that long‐term cross‐correlation has a more considerable degree of multifractality and persistence than short‐term cross‐correlation.
Light vector meson photoproduction in ultraperipheral heavy‐ion collisions at the LHC within the Reggeometric Pomeron approach
Authors: Jenkovszky László , Rocha Érison S. , Machado Magno V. T. 
Published: January 2023

AbstractBy using the Reggeometric Pomeron model for vector meson production which successfully describes the high energy lepton‐nucleon data, we analyze the light meson production in ultra‐peripheral heavy‐ion collisions at the Large Hadron Collider (LHC). The rapidity distributions for ρ and ϕ photoproduction in lead–lead, xenon–xenon and oxygen– oxygen collisions are investigated.
CRISPR‐interceded CHO cell line development approaches
Authors: Amiri Shahin , Adibzadeh Setare , Ghanbari Samaneh , Rahmani Behnaz , Kheirandish Mohammad H. , Farokhi‐Fard Aref , Dastjerdeh Mansoureh S. , Davami Fatemeh 
Published: January 2023

AbstractFor industrial production of recombinant protein biopharmaceuticals, Chinese hamster ovary (CHO) cells represent the most widely adopted host cell system, owing to their capacity to produce high‐quality biologics with human‐like posttranslational modifications. As opposed to random integration, targeted genome editing in genomic safe harbor sites has offered CHO cell line engineering a new perspective, ensuring production consistency in long‐term culture and high biotherapeutic expression levels. Corresponding the remarkable advancements in knowledge of CRISPR‐Cas systems, the use of CRISPR‐Cas technology along with the donor design strategies has been pushed into increasing novel scenarios in cell line engineering, allowing scientists to modify mammalian genomes such as CHO cell line quickly, readily, and efficiently. Depending on the strategies and production requirements, the gene of interest can also be incorporated at single or multiple loci. This review will give a gist of all the most fundamental recent advancements in CHO cell line development, such as different cell line engineering approaches along with donor design strategies for targeted integration of the desired construct into genomic hot spots, which could ultimately lead to the fast‐track product development process with consistent, improved product yield and quality.
Business models for sustainability and firms' external relationships—A systematic literature review with propositions and research agenda
Authors: Stål Herman I. , Riumkin Ivan , Bengtsson Maria 
Published: January 2023

AbstractIncreased focus on sustainability has made firms' value creation increasingly boundary spanning and complex. This begs the question of how business model research describes firm's external relationships, motivating us to undertake a systematic literature review. In analyzing 49 articles, we discuss and problematize four conceptualizations of external relationships—collaboration, alliances, networks, and ecosystems—arriving at nine propositions that clarify their meaning and refer to either firm‐centric or collective business models for sustainability. In combining these findings with review results from conventional business model research we identify three main blind spots in extant business model for sustainability research, regarding coopetition, wider inter‐organizational and sustainability tensions, and power. Based on these blind spots, we sketch a research agenda that could theorize business models for sustainability without neglecting their inherent tensions and contradictions.
Awe and guilt: Desirability and feasibility appeals in social media green campaigns
Authors: Kim Seeun , Childs Michelle L. , Baek Tae Hyun 
Published: January 2023

AbstractAs the world has become increasingly concerned about environmental plastic pollution, private and public sectors remain devoted to creating effective green marketing campaigns on social media platforms. Drawing upon construal level theory and appraisal tendency theory, this research examines the interaction effect of green ad appeals and two distinct emotions—awe and guilt—on consumers' social media engagement and pro‐environmental intentions. The findings from two experimental studies demonstrate that when individuals experience awe, desirability (vs. feasibility) message appeals generate stronger engagement in social media green campaigns. In contrast, it was found that when individuals experience guilt, feasibility (vs. desirability) message appeals enhance social media engagement and pro‐environmental behaviors more effectively. This research offers novel theoretical contributions to the existing body of literature and provides practical insights by suggesting that awe and guilt act as moderators leading to greater consumer responses when used with matching social media messages promoting green campaigns.
Targeted treatment of refractory primitive neuroectodermal tumor arising from an immature teratoma with crizotinib leading to a sustained response
Authors: Snyder Benjamin M. , Lion Alex H. , Helvie Amy E. , Marshall Mark S. , Ferguson Michael J. 
Published: January 2023

AbstractHere we present a case of metastatic PNET which arose from an immature teratoma that was refractory to standard Ewing sarcoma chemotherapy. This PNET was determined to have elevated levels of ALK protein via IHC. The patient was treated with crizotinib on a palliative basis with a sustained response.
Streptococcus‐related acute suppurative thyroiditis in a COVID‐19‐positive child: A rare case report
Authors: Maleki Elham , Iranmanesh Kimia , Najafzadeh Mohammad Javad , Baniasad Amir 
Published: January 2023

AbstractIn this case report, we present a 10‐year‐old girl with acute suppurative thyroiditis (AST) symptoms, such as fever, sore throat, and swelling in the suprasternal region, who had a positive PCR test for COVID‐19. The result of the secretions culture obtained from the abscess drainage was positive for nonhemolytic Streptococcus.
Green Synthesis and Analytical Characterization of Core‐Shell Copper Sub‐Microparticles
Authors: Sportelli Maria Chiara , Picca Rosaria Anna , Izzi Margherita , Cioffi Nicola 
Published: January 2023

AbstractThis study demonstrates a simple and reproducible approach to synthesize green core‐shell copper sub‐microparticles stabilized by poly(n‐vinyl)pyrrolidone (PVP). Cu@PVP colloids were here prepared using copper sulfate pentahydrate as precursor and glucose as reducing agent. The presence of PVP in the synthetic medium eliminates the need for an inert atmosphere during the process, thus simplifying the whole method. Both the morphology and the spectroscopic properties of Cu@PVP colloids were investigated by transmission electron microscopy, and infrared, UV‐Vis and X‐ray photoelectron spectroscopies. Size distributions and average shell thickness were obtained by statistical analysis on TEM micrographs, and spectroscopies demonstrated the formation of a PVP layer around the copper core. The produced colloids were employed in composite thin films for potential antimicrobial application, in association with a highly‐recyclable polymer: polycarbonate (4,4’‐(1‐methylethylidene)bis(phenol)).
Templating Influence of Regulated Inorganic Framework in Two‐Dimensional Ferroelastic Perovskites: (C3H5CH2NH3)2[MCl4] (M=Mn and Cd)
Authors: Yin Ti‐Jian , Xu Ke , He Lei , Meng Xin , Xu Yan , Men Jin‐Tiao , Mu Jie , Ye Qiong , Shi Ping‐Ping 
Published: January 2023

AbstractThe remarkable material stability and structural diversity of two‐dimensional (2D) organic‐inorganic hybrid perovskites (OIHPs) constitute a vast available library of versatile materials. In particular, ferroelastic property, for which the spontaneous strain can be transformed by applying mechanical stress, is very promising for extensive nanotechnological applications. However, integrating ferroelastic property into 2D OIHPs is still in its infancy. Herein, we designed two new 2D OIHPs (C3H5CH2NH3)2[MCl4] (M=Mn for 1 and Cd for 2), which undergo reversible ferroelastic phase transitions with an Aizu expression 4/mmmFmmm. The templating influence of the more distorted inorganic framework on the disordering of organic cations and the stronger hydrogen bonds has a key role in the striking improvement of Curie temperature from 246 K in 1 to 273 K in 2. Meanwhile, the minimized alteration of structural motif ensures the well maintaining of the ferroelastic performance in the forms of crystals and thin films, as demonstrated by the identifiable evolution of domain structures. This work will provide a fertile new ground for enlarging the limited number of 2D ferroelastic OIHPs with better practical utility.
Gold Teflates Revisited: From the Lewis Superacid [Au(OTeF5)3] to the Anion [Au(OTeF5)4]−
Authors: Winter Marlon , Peshkur Natallia , Ellwanger Mathias A. , Pérez‐Bitrián Alberto , Voßnacker Patrick , Steinhauer Simon , Riedel Sebastian 
Published: January 2023

AbstractA new synthetic access to the Lewis acid [Au(OTeF5)3] and the preparation of the related, unprecedented anion [Au(OTeF5)4]−with inorganic or organic cations starting from commercially available and easy‐to‐handle gold chlorides are presented. In this first extensive study of the Lewis acidity of a transition‐metal teflate complex by using different experimental and quantum chemical methods, [Au(OTeF5)3] was classified as a Lewis superacid. The solid‐state structure of the triphenylphosphine oxide adduct [Au(OPPh3)(OTeF5)3] was determined, representing the first structural characterization of an adduct of this highly reactive [Au(OTeF5)3]. Therein, the coordination environment around the gold center slightly deviates from the typical square planar geometry. The [Au(OTeF5)4]−anion shows a similar coordination motif.
Crystallization of a Neptunyl Oxalate Hydrate from Solutions Containing NpV and the Uranyl Peroxide Nanocluster U60Ox30
Authors: Smith Kyson R. , Ilavsky Jan , Hixon Amy E. 
Published: January 2023

AbstractUranyl peroxide nanoclusters are an evolving family of materials with potential applications throughout the nuclear fuel cycle. While several studies have investigated their interactions with alkali and alkaline earth metals, no studies have probed their interactions with the actinide elements. This work describes a system containing U60Ox30, [((UO2)(O2))60(C2O4)30]60−, and neptunium(V) as a function of neptunium concentration. Ultra‐small and small angle X‐ray scattering were used to observe these interactions in the aqueous phase, and X‐ray diffraction was used to observe solid products. The results show that neptunium induces aggregation of U60Ox30 when the neptunium concentration is≤10 mM, whereas (NpO2)2C2O4 ⋅ 6H2O(cr) and studtite ultimately form at 15–25 mM neptunium. The latter result suggests that neptunium coordinates with the bridging oxalate ligands in U60Ox30, leaving metastable uranyl peroxide species in solution. This is an important finding given the potential application of uranyl peroxide nanoclusters in the recycling of used nuclear fuel.
Dendrite‐Free Engineering toward Efficient Zinc Storage: Recent Progress and Future Perspectives
Authors: Miao Ling , Zhang Jinmao , Lv Yaokang , Gan Lihua , Liu Mingxian 
Published: January 2023

AbstractZinc‐based energy storage has lately gained popularity due to natural abundance, operational safety, high energy density. Unfortunately, dendrite growth is a common and intractable issue faced in existing zinc‐ion batteries to shorten cycle lifespan/stability. This review summarizes recent progress in assembly component (e. g., anode, electrolyte, separator) engineering for dendrite‐free zinc‐ion batteries. First, diversiform strategies of Zn surface modification and Zn host design are presented to shield the fundamental adverse effect aroused by uneven zinc deposition on the anode. Then, subtle deployments of electrolyte constituents are illustrated to optimize the Zn2+solvation structure for ultimate dendrite control and Coulombic efficiency elevation in aqueous systems and beyond (e. g., eutectic electrolytes). Furthermore, rational manipulation of advanced separators and the upgrade of zinc metal‐free Zn2+‐storage devices are briefly discussed to explore the dendrite‐free and high‐level Zn2+‐storage. Finally, challenges and perspectives are proposed to offer research inspirations toward safe, high‐efficiency and long‐lifespan zinc storage.
Process Engineering and Glycosyltransferase Improvement for Short Route Chemoenzymatic Total Synthesis of GM1 Gangliosides
Authors: Yu Hai , Zhang Libo , Yang Xiaohong , Bai Yuanyuan , Chen Xi 
Published: January 2023

AbstractLarge‐scale synthesis of GM1, an important ganglioside in mammalian cells especially those in the nervous system, is needed to explore its therapeutic potential. Biocatalytic production is a promising platform for such a purpose. We report herein the development of process engineering and glycosyltransferase improvement strategies to advance chemoenzymatic total synthesis of GM1. Firstly, a new short route was developed for chemical synthesis of lactosylsphingosine from the commercially available Garner's aldehyde. Secondly, two glycosyltransferases including Campylobacter jejuni β1–4GalNAcT (CjCgtA) and β1–3‐galactosyltransferase (CjCgtB) were improved on their soluble expression in E. coli and enzyme stability by fusing with an N‐terminal maltose binding protein (MBP). Thirdly, the process for enzymatic synthesis of GM1 sphingosines from lactosylsphingosine was engineered by developing a multistep one‐pot multienzyme (MSOPME) strategy without isolating intermediate glycosphingosines and by adding a detergent, sodium cholate, to the later enzymatic glycosylation steps. Installation of a desired fatty acyl chain to GM1 glycosphingosines led to the formation of target GM1 gangliosides. The combination of glycosyltransferase improvement with chemical and enzymatic process engineering represents a significant advance in obtaining GM1 gangliosides containing different sialic acid forms by total chemoenzymatic synthesis in a short route and with high efficiency.
Design and Analysis of Charge‐Reduced Refrigerant Cycles Using R290
Authors: Schnabel Lena , Methler Timo , Hassan Abdelrahman H. , Dankwerth Clemens , Maciá José María Gonzálvez 
Published: January 2023

AbstractR290 is one of the most promising refrigerants for heat pumps and cooling processes working in a temperature range of –15 to 70 °C. The nearly neglectable global warming potential and attractive thermodynamic properties allow the design of climate‐friendly and efficient refrigeration systems and heat pumps. However, R290 is flammable, and the use of charge‐reduced components and designs should be the first central step to reduce safety risks. Whereas the prediction of heat capacity, temperatures and pressure drops are sufficiently precise the prediction of refrigerant charge is not very accurate when using computer‐aided design tools. The article presents a method to enhance accuracy for refrigerant cycles with less than 500 g of R290.
Tales from the Other Side: An Exploratory Study of the Effects of Third‐party Enforced Psychological Contract Breach Risk on Breachers and their Relationships During a Work‐to‐rule Teacher Strike
Authors: Michaud James , Somogyvari Gabor 
Published: January 2023

AbstractLittle research has been done on psychological contract breach situations from the perspective of the breacher, including situations in which potential breach actions were enforced by a third‐party. This exploratory study aims to see how enforced breach affects the breacher, their reactions to the situation, and their relationships with community stakeholders. Semi‐structured long‐form interviews with Canadian teachers whose union decided to go on a work‐to‐rule strike, risking relational breaches with school community stakeholders, were undertaken. Teachers experienced negative emotions and engaged in breach mitigating actions. Implications include being aware of the negative effects on unwilling breachers and the relationships with the source of breaches, and the possibility of mitigating breaches while still removing obligations if breachers engage in mitigating actions.
Spatial PD‐L1, immune‐cell microenvironment, and genomic copy‐number alteration patterns and drivers of invasive‐disease transition in prospective oral precancer cohort
Authors: William William N. , Zhang Jianjun , Zhao Xin , Parra Edwin R. , Uraoka Naohiro , Lin Heather Y. , Peng S. Andrew , El‐Naggar Adel K. , Rodriguez‐Canales Jaime , Song Jaejoon , Gillenwater Ann M. , Wistuba Ignacio I. , Myers Jeffrey N. , Gold Kathryn A. , Ferrarotto Renata , Hwu Patrick , Davoli Teresa , Lee J. Jack , Heymach John V. , Papadimitrakopoulou Vassiliki A. , Lippman Scott M. 
Published: January 2023

AbstractBackgroundStudies of the immune landscape led to breakthrough trials of programmed death‐1 (PD‐1) inhibitors for recurrent/metastatic head and neck squamous cell carcinoma therapy. This study investigated the timing, influence of somatic copy‐number alterations (SCNAs), and clinical implications of PD‐L1 and immune‐cell patterns in oral precancer (OPC).MethodsThe authors evaluated spatial CD3, CD3/8, and CD68 density (cells/mm2) and PD‐L1 (membranous expression in cytokeratin‐positive intraepithelial neoplastic cells and CD68) patterns by multiplex immunofluorescence in a 188‐patient prospective OPC cohort, characterized by clinical, histologic, and SCNA risk factors and protocol‐specified primary end point of invasive cancer. The authors used Wilcoxon rank‐sum and Fisher exact tests, linear mixed effect models, mediation, and Cox regression and recursive‐partitioning analyses.ResultsEpithelial, but not CD68 immune‐cell, PD‐L1 expression was detected in 28% of OPCs, correlated with immune‐cell infiltration, 9p21.3 loss of heterozygosity (LOH), and inferior oral cancer‐free survival (OCFS), notably in OPCs with low CD3/8 cell density, dysplasia, and/or 9p21.3 LOH. High CD3/8 cell density in dysplastic lesions predicted better OCFS and eliminated the excess risk associated with prior oral cancer and dysplasia. PD‐L1 and CD3/8 patterns revealed inferior OCFS in PD‐L1 high intrinsic induction and dysplastic immune‐cold subgroups.ConclusionThis report provides spatial insight into the immune landscape and drivers of OPCs, and a publicly available immunogenomic data set for future precancer interrogation. The data suggest that 9p21.3 LOH triggers an immune‐hot inflammatory phenotype; whereas increased 9p deletion size encompassing CD274 at 9p24.1 may contribute to CD3/8 and PD‐L1 depletion during invasive transition. The inferior OCFS in PD‐L1‐high, immune‐cold OPCs support the development of T‐cell recruitment strategies.
Culturing and Imaging Glioma Stem Cells in 3D Collagen Matrices
Authors: Cowan James M. , Juric Matey , Petrie Ryan J. 
Published: January 2023

AbstractMethods to maintain human glioma stem cells as neurosphere cultures and image their dynamic behavior in 3D collagen matrices are described. Additional approaches to monitor glioma stem cell differentiation into mesenchymal‐type cells, along with example data are included. Together, these approaches enable glioma stem cell differentiation to be controlled while maintaining the cells in culture, as well as allowing cell dynamics to be captured and analyzed. These methods should be helpful for those seeking to understand the molecular mechanisms driving the invasion of glioma cells through three‐dimensional environments. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Culturing human glioma stem cells as neurospheresBasic Protocol 2: Inducing GSC adherence and monitoring their differentiation into mesenchymal cellsSupport Protocol 1: Preparing fibronectin‐coated dishes for cell microscopyBasic Protocol 3: Embedding GSCs in a 3D collagen matrix to study their invasive behaviorSupport Protocol 2: Phase‐contrast imaging with a tiled matrix to study cell migration in a 3D gel
Analysis of full reference quality metrics for image transmission over a MIMO OWC channel under varying turbulent conditions
Authors: Gill Harpuneet Singh , Singh Maninder Lal , Singh Mandeep , Priyanka  , Kaur Sehajpal , Kaur Hardeep 
Published: January 2023

SummaryThe integrated OWC‐PON architecture has a potential to overcome the limitations of existent RF technology and eliminate the last mile bottleneck in geographically constrained access networks thus providing real sense broadband from core to user. However, phenomenon such as atmospheric turbulence causes performance degradation in such systems. In the dissemination of multimedia services, the performance is the ultimate quality as perceived by end user's visual senses. To ascertain this quality in quantitative terms, full reference quality metrics are employed for communication purposes. This paper deals with classification, evaluation and analysis of various image quality assessment metrics for image transmission over OWC channel under varying turbulent conditions. The performance enhancement in terms of these metrics is investigated by deploying MIMO diversity reception. Moreover, a prediction model for SSIM is developed and compared for both SISO and MIMO links. The results show an improvement in IQA metrics with diversity reception. SSIM can be predicted in terms of log of refractive index structure parameter by a fourth order polynomial model for both SISO and MIMO receptions under all regimes of turbulence. The goodness of the fit statistics is presented along with the models to provide for their accuracy and reliability.