bluuebunny/crossref_metadata_2025_split huggingface dataset:
The historical trajectory of a coffee agri-food system: A case study in Oaxaca, Mexico
Authors: Ramírez-León Alejandra , Avila-Foucat Veronique Sophie , Ezzine-de-Blas Driss 
Published: July 2023

Abstract
Agri-food social-ecological systems (AFSES) embrace complex interactions and processes of food production, processing, and commercialization that are subject to constant changes. This study develops a heuristic approach using the adaptive cycle (AC) and a transformation potential measure to identify the historical trajectory of a coffee AFSES at a watershed scale in Copalita, Mexico, over 40 years from 1980 to 2020. Primary information was collected through semistructured interviews. The results show that the system interactions depend on economic, social, and environmental stressors and shocks affecting different temporal and spatial scales. The cumulative effects of driving forces and adaptive strategies have influenced the system to not complete the AC phases. Additionally, the results show that some adaptive strategies can become new stressors with time. Driving forces, adaptive strategies, tipping points, trade-offs and interactions within the AFSES could be identified as the main aspects defining system resilience.
Sustainable utilization and valorization of potato waste: state of the art, challenges, and perspectives
Authors: Khanal Sonali , Karimi Keikhosro , Majumdar Sneha , Kumar Vinod , Verma Rachna , Bhatia Shashi Kant , Kuca Kamil , Esteban Jesús , Kumar Dinesh 
Published: July 2023

AbstractPotatoes (Solanum tuberosum L.) are starchy tuberous crops that represent the world’s fourth most important crop. According to the “Food and Agricultural Organisation of the United Nations,” 376 million metric tonnes of potatoes were produced globally in 2021. It is anticipated that around 8000 kilotons of potato peel waste might be generated in 2030, with related greenhouse gas emissions of 5 million tonnes of CO2 equivalent. Waste generated throughout the food supply chain, from potato farms to forks, contributes considerably to global warming. Apart from animal feed, technical processes in the potato processing industry generate waste organic residues with high amounts of bioactive compounds and carbohydrates, and thus extraction and bioconversion processes can produce high-value products. These include the isolation of functional ingredients for the formulation of nutraceuticals and pharma products, bioenergy-related products, enzymes, and fertilizers for the market, hence contributing to a more responsible production and consumption and, overall, circular economy. This review focuses on studies involving potato waste from industries such as pulp, processed water, peels, and mash showing the great prospects of the by-products from this crop for value-added supply chains and the reduction of undesired environmental effects. This work attempts to adhere upon several Sustainable Development Goals, specifically goals 7, 12, and 13, while also contributing to long-term growth targets and reducing negative environmental consequences produced by the food sector.
Geoid model determination for the Hellenic area “Hellas Geoid 2023”
Authors: Paraskevas Melissinos , Papadopoulos Nestoras , Ampatzidis Dimitrios 
Published: July 2023

AbstractThe latest geoid model "HELLAS GEOID 2023" (HG2023) derived by the Hellenic Military Geographical Service is the most comprehensive model for the entire Hellenic area. Long-term gravity data, orthometric and geometric heights, seabed topography and a high-resolution digital terrain model were implemented in the calculations. Data evaluation and their accuracy estimation were of major importance to ascertain compatibility among data sources. In this study, data from neighboring countries were used as they were essential for the completeness of the model developed. The technique remove–compute–restore was adopted for the separation of the gravity signal in the heterogeneous data utilizing EIGEN 6C4 (full degree and order 2190), since the global geodynamic model was found to fit best in the Greek region. Mean gravity residual contribution to the local geoid model was calculated using Stokes' theorem in the frequency domain and implementing the Fourier transform using the Wang and Core modification. The final surface of the resulting gravimetric geoid was adapted to the existing height system of the State utilizing the Least Squares Collocation method by fitting points of known orthometric and geometric heights, distributed throughout Greece. The external accuracy of the estimated geoid model was estimated at the level of 6 cm.
Construction and validation of a risk prediction model for intraoperative hypothermia in elderly patients undergoing total hip arthroplasty
Authors: zhao Bin , zhu Zhe , Qi Wenwen , Liu Qiuli , Zhang Qi , Jiang Liping , Wang Chenglong , Weng Xiaojian 
Published: July 2023

Abstract
Aims
To construct and validate an intraoperative hypothermia risk prediction model for elderly patients undergoing total hip arthroplasty (THA).

Methods
We collected data from 718 patients undergoing THA in a tertiary hospital from January 2021 to December 2022. Of these patients, 512 were assigned to the modeling group from January 2021 to April 2022, and 206 participants were assigned to the validation group from May 2022 to December 2022. A logistic regression analysis was performed to construct the model. The area under the curve (AUC) was used to test the model’s predictive ability.

Results
The incidence rate of intraoperative hypothermia was 51.67%. The risk factors entered into the risk prediction model were age, preoperative hemoglobin level, intraoperative blood loss, postoperative hemoglobin level, and postoperative systolic blood pressure. The model was constructed as follows: logit (P) = − 10.118 + 0.174 × age + 1.366 × 1 (preoperative hemoglobin level) + 0.555 × 1 (postoperative hemoglobin level) + 0.009 × 1 (intraoperative blood loss) + 0.066 × 1 (postoperative systolic blood pressure). Using the Hosmer–Lemeshow test, the P value was 0.676 (AUC, 0.867). The Youden index, sensitivity, and specificity were 0.602, 0.790, and 0.812, respectively. The incidence rates of intraoperative hypothermia in the modeling and validation groups were 53.15% and 48.06%, respectively. The correct practical application rate was 89.81%. This model had good application potential.

Conclusions
This risk prediction model has good predictive value and can accurately predict the occurrence of intraoperative hypothermia in patients who undergo THA, which provides reliable guidance for clinical work and has good clinical application value.
Natural gas odorants: A scoping review of health effects
Authors: Michanowicz Drew R. , Leventhal Olivia M. , Domen Jeremy K. , Williams Samuel R. , Lebel Eric D. , Hill Lee Ann L. , Buonocore Jonathan J. , Nordgaard Curtis L. , Bernstein Aaron S. , Shonkoff Seth B.C. 
Published: July 2023

Abstract
Purpose of Review
Organosulfur compounds are intentionally added to natural gas as malodorants with the intent of short-term nasal inhalation to aid in leak detection. Regulatory exposure limits have not been established for all commonly used natural gas odorants, and recent community-level exposure events and growing evidence of indoor natural gas leakage have raised concerns associated with natural gas odorant exposures. We conducted a scoping review of peer-reviewed scientific publications on human exposures and animal toxicological studies of natural gas odorants to assess toxicological profiles, exposure potential, health effects and regulatory guidelines associated with commonly used natural gas odorants.

Recent Findings
We identified only 22 studies which met inclusion criteria for full review. Overall, there is limited evidence of both transient nonspecific health symptoms and clinically diagnosed causative neurotoxic effects associated with prolonged odorant exposures. Across seven community-level exposure events and two occupational case reports, consistent symptom patterns included: headache, ocular irritation, nose and throat irritation, respiratory complaints such as shortness of breath and asthma attacks, and skin irritation and rash. Of these, respiratory inflammation and asthma exacerbations are the most debilitating, whereas the high prevalence of ocular and dermatologic symptoms suggest a non-inhalation route of exposure.

Summary
The limited evidence available raises the possibility that organosulfur odorants may pose health risks at exposures much lower than presently understood, though additional dose-response studies are needed to disentangle specific toxicologic effects from nonspecific responses to noxious organosulfur odors. Numerous recommendations are provided including more transparent and prescriptive natural gas odorant use practices.
A Paradigm Shift from International to Transnational Medical Education
Authors: Patel Dhaval , Mullen Michael , Eley Diann S. 
Published: July 2023

AbstractIn recent years, the number of medical students seeking international opportunities has grown. To satisfy these demands, collaborative international programs have been developed. However, the benefits of these programs are limited as they employ an international medical education (IME) approach where only the students are exchanged. In this commentary, we discuss the current models of IME and propose a paradigm shift to a transnational approach wherein the student, faculty, and curriculum are exchanged allowing for increased integration and awareness of cultural and educational approaches to treatment that can be retained and incorporated into future practice to advance healthcare across the globe.
The Solutrean Antlerworking in Hort de Cortés–Volcán del Faro (Valencia, Spain) in the Southwest Europe Context: a Preliminary Study
Authors: Borao M. , Pérez L. , Vadillo Conesa M. , Vidal Matutano P. , Soler Mayor B. , Aura Tortosa J. E. 
Published: July 2023

AbstractIn this work, we present a preliminary analysis of the Solutrean antlerworking at Hort de Cortés–Volcán del Faro (Valencia, Spain) (ca. 26–21 ka cal BP). A restudy of its archaeological sequence, which came to encompass the Early Upper Palaeolithic to the Magdalenian period, has been a mandatory subject in the last years. This site became an archaeological reference since the beginning of its excavation in the 1960s but has not been systematically studied. The implementation of more specialized studies is used a) to observe the distribution of technical pieces in the stratigraphy and identify possible stratigraphic alterations and b) to restudy a huge lithic, osseous, and faunal collection which can provide new information that may clarify them. The aim is to develop a systematic study, from a technological point of view, to identify and characterize operational schemes and to define the modalities of antlerworking. The technological analysis of waste products, blanks, roughouts, and objects allows us to observe how raw material is obtained and transformed into a toolkit following the refitting by default method. It will help us analyze some questions about the raw material acquisition and transformation like (1) selection between hunted and shed antlers and its possible explanation, (2) the existence of planning of tool manufacture, and (3) the step-by-step production of the debitage. We will extract conclusions and analyze different social aspects: (1) by identifying technical traditions and comparing them with other studied sites and periods and (2) by knowing a new aspect of the way of life of these human groups.
Physiological and Agronomic Responses and Nutrient Uptake of Soybean Genotypes Cultivated Under Various Sowing Dates
Authors: Shahin Mostafa G. , Saudy Hani S. , El-Bially Mohamed E. , Abd El-Momen Wasfi R. , El-Gabry Yasser A. , Abd El-Samad Gomaa A. , Sayed Amany N. 
Published: July 2023

AbstractLate or early sowing subjecting crop plants to stress conditions, this is simulating the climatic change effects. The global warming and climate change are critical issues in agriculture since progressive rise in temperature leads to exposure the crops to heat stress, hence low productivity. Since weather conditions are uncontrollable, it is impossible to modulate their negative impacts against crop growth and development. However, scientists should not be handcuffed about this serious problem. So, in open field conditions, the performance of some soybean genotypes was evaluated under different sowing dates. Along the two seasons of 2019 and 2020, field experiments were designed in a split-plot design using three replicates to evaluate the performance of four soybean genotypes (Giza-21, Giza-35, Giza-111, and Crawford) under four sowing dates (15th April, 30th April, 15th May, and 30th May). Various physiological and growth traits, yield attributes, seed nutrient contents, and oil and protein contents were estimated. Sowing Crawford (in both seasons) and Giza-35 (in the first season) on 15th April as well as Giza-111 either on 30th April or 15th May produced the highest catalase activity. In plots sown on 30th April, Crawford and Giza-21 (in the first season) and Giza-111 (in both seasons) exhibited the highest leaves area plant−1. Plots sown by Giza-111 on 30th April was the potent interaction for enhancing seed yield in both seasons. Under any sowing date in the second season and the sowing date of 30th April in the first season, Giza-111 was the effective genotype for recording the maximum seed oil content. For adopting a specific stress condition scenario, it is advisable to insert Giza-111 as an effective gene pool to improve soybean genotypes under unfavorable conditions, expressed in sowing dates.
Inverse design of composite xylophone beams using finite element-based machine learning
Authors: Kimura Tatsuro , Ji Ming , Onodera Ryu , Sekiguchi Yu , Sato Chiaki 
Published: July 2023

AbstractWood, as one of the important materials to make music instruments, has many drawbacks, including its sensitivity to changes in temperature and humidity, the lack of available wood resources, the significant variability of wood, and the demanding level of expertise needed. New materials such as composites are needed to be developed to be substitutes for woods. In this study, a finite element (FE)-based machine learning method is proposed to design a xylophone using sandwich beam as a substitute to wood. A finite element (FE) procedure based on a higher order layer-wise beam theory is developed. In addition, a machine learning model is developed to predict the natural frequencies of sandwich beams. The model is designed and trained to consider the results obtained from developed FE procedure as input and predict accurate natural frequencies. The results recorded from this model are compared with the experimental values. Then, inverse analysis is performed to design sandwich beam of different geometric sizes for constrained natural frequencies using machine learning.
Automating Intervention in Chinese Justice: Smart Courts and Supervision Reform
Authors: Papagianneas Straton 
Published: July 2023

AbstractThis article examines how smart courts enhance the reform of judicial responsibility and the “trial supervision and management” mechanism. It holds that smart courts, while meant to provide better judicial services and improve access to justice, have the additional goal of enhancing the restructuring of accountability and power structures. It argues that automation and digitization help institutionalize and codify political supervision. Smart courts help resolve tension between the two opposing requirements of Chinese courts to maintain legal rationality and independent adjudication on the one hand, and the need for flexibility to allow intervention on the other. This article provides an account of the automation of “trial supervision and management” and explores the role of technology in enhancing political intervention in China’s legal system. This investigation draws on internal court reports and central and local judicial documents, supplemented with a review of Chinese empirical scholarship.
Sound-symbolic association between speech sound and spatial meaning in relation to the concepts of up/down and above/below
Authors: Vainio Lari , Wikström Alexandra , Repetto Claudia , Vainio Martti 
Published: July 2023

AbstractResearch has shown sound-symbolic associations between speech sounds and conceptual and/or perceptual properties of a referent. This study used the choice response time method to investigate hypothesized associations between a high/low vowel and spatial concepts of up/down and above/below. The participants were presented with a stimulus that moved either upward or downward (Experiments 1 and 2), or that was located above or below the reference stimulus (Experiment 3), and they had to pronounce a vowel ([i] or [æ]) based on the spatial location of the stimulus. The study showed that the high vowel [i] was produced faster in relation to the up-directed and the above-positioned stimulus, while the low vowel [æ] was produced faster in relation to the down-directed and the below-positioned stimulus. In addition, the study replicated the pitch-elevation effect showing a raising of the vocalization pitch when vocalizations were produced to the up-directed stimulus. The article discusses these effects in terms of the involvement of sensorimotor processes in representing spatial concepts.
The regulation of the rural market in waged labour in fourteenth-century England
Authors: Bailey Mark 
Published: July 2023

AbstractThis article reconstructs the size and organisation of the rural market in hired labour in fourteenth-century England, providing a comparative reference point for arrangements elsewhere in medieval Europe. Quantitative assessment of 1,445 manorial court sessions from six manors casts new light on the English labour market, which was larger and less regulated than previously assumed and the government's wide-ranging labour legislation in the wake of the Black Death was novel in its scale and provisions. Contrary to received wisdom, manorial authorities made few efforts to regulate labour. The older view had placed an over-reliance on the early work of W.O. Ault and had ignored the significance of nil returns. The reasons for the lack of regulation, and its implications for our understanding of the complex interaction between pandemics, labour markets, and legal responses are explored. Finally, the study illustrates how legal responses to pandemics can have inadvertent yet profound consequences.
Profiling of plasma biomarkers in the context of memory assessment in a tertiary memory clinic
Authors: Bucci Marco , Bluma Marina , Savitcheva Irina , Ashton Nicholas J. , Chiotis Konstantinos , Matton Anna , Kivipelto Miia , Di Molfetta Guglielmo , Blennow Kaj , Zetterberg Henrik , Nordberg Agneta 
Published: July 2023

AbstractPlasma biomarkers have shown promising performance in research cohorts in discriminating between different stages of Alzheimer’s disease (AD). Studies in clinical populations are necessary to provide insights on the clinical utility of plasma biomarkers before their implementation in real-world settings. Here we investigated plasma biomarkers (glial fibrillary acidic protein (GFAP), tau phosphorylated at 181 and 231 (pTau181, pTau231), amyloid β (Aβ) 42/40 ratio, neurofilament light) in 126 patients (age = 65 ± 8) who were admitted to the Clinic for Cognitive Disorders, at Karolinska University Hospital. After extensive clinical assessment (including CSF analysis), patients were classified as: mild cognitive impairment (MCI) (n = 75), AD (n = 25), non-AD dementia (n = 16), no dementia (n = 9). To refine the diagnosis, patients were examined with [18F]flutemetamol PET (Aβ-PET). Aβ-PET images were visually rated for positivity/negativity and quantified in Centiloid. Accordingly, 68 Aβ+ and 54 Aβ– patients were identified. Plasma biomarkers were measured using single molecule arrays (SIMOA). Receiver-operated curve (ROC) analyses were performed to detect Aβ-PET+ using the different biomarkers. In the whole cohort, the Aβ-PET centiloid values correlated positively with plasma GFAP, pTau231, pTau181, and negatively with Aβ42/40 ratio. While in the whole MCI group, only GFAP was associated with Aβ PET centiloid. In ROC analyses, among the standalone biomarkers, GFAP showed the highest area under the curve discriminating Aβ+ and Aβ– compared to other plasma biomarkers. The combination of plasma biomarkers via regression was the most predictive of Aβ-PET, especially in the MCI group (prior to PET, n = 75) (sensitivity = 100%, specificity = 82%, negative predictive value = 100%). In our cohort of memory clinic patients (mainly MCI), the combination of plasma biomarkers was sensitive in ruling out Aβ-PET negative individuals, thus suggesting a potential role as rule-out tool in clinical practice.
Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial
Authors: Spicer James , Basu Bristi , Montes Ana , Banerji Udai , Kristeleit Rebecca , Miller Rowan , Veal Gareth J. , Corrigan Christopher J. , Till Stephen J. , Figini Mariangela , Canevari Silvana , Barton Claire , Jones Paul , Mellor Sarah , Carroll Simon , Selkirk Chris , Nintos George , Kwatra Vineet , Funingana Ionut-Gabriel , Doherty Gary , Gould Hannah J. , Pellizzari Giulia , Nakamura Mano , Ilieva Kristina M. , Khiabany Atousa , Stavraka Chara , Chauhan Jitesh , Gillett Cheryl , Pinder Sarah , Bax Heather J. , Josephs Debra H. , Karagiannis Sophia N. 
Published: July 2023

AbstractAll antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT02546921) with the primary objective of exploring the safety and tolerability of MOv18 IgE, a chimeric first-in-class IgE antibody, in patients with tumours expressing the relevant antigen, folate receptor-alpha. The trial incorporated skin prick and basophil activation tests (BAT) to select patients at lowest risk of allergic toxicity. Secondary objectives were exploration of anti-tumour activity, recommended Phase II dose, and pharmacokinetics. Dose escalation ranged from 70 μg–12 mg. The most common toxicity of MOv18 IgE is transient urticaria. A single patient experienced anaphylaxis, likely explained by detection of circulating basophils at baseline that could be activated by MOv18 IgE. The BAT assay was used to avoid enrolling further patients with reactive basophils. The safety profile is tolerable and maximum tolerated dose has not been reached, with evidence of anti-tumour activity observed in a patient with ovarian cancer. These results demonstrate the potential of IgE therapy for cancer.