bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Status and Development Prospect of Wellbore Integrity in China
Authors: Zhang Zhi , Zhao Yuanjin , Cai Nan , Xiang Shilin , Ding Chenyu 
Published: September 2023

Summary
As the exploration and development of oil and gas move into increasingly challenging locations and harsher environments, well integrity becomes more difficult to maintain. High temperatures, pressures, and corrosion can all contribute to wellbore integrity failure. Such failures can have significant financial and environmental consequences, including gas leakage and fluid spills. In this paper, we review the development and technical advancements of wellbore integrity research both in China and abroad and look forward to the development direction of wellbore integrity in China. We provide basic background knowledge for those interested in wellbore integrity and also share the progress and development direction of integrity research for wellbore integrity researchers. Through research and analysis, some conclusions can be drawn.
Countries around the world are actively studying wellbore integrity and have developed a large number of standards, especially the United States and Norway, which have the most standards. The most common way to analyze wellbore integrity is to first divide the entire wellbore into different wellbore barrier units according to different standards, such as ISO 16530-1, and then study risk factors and integrity management measures in different units. Mainstream research is mostly carried out around the integrity of casing, cement, and tubing, and many achievements have been made, but the study of packer and downhole safety valve is still on the way. Wellbore integrity risk assessment aims to quantify potential risks and establish risk levels to support decision-making for on-site wellbore integrity control. This is achieved by identifying factors affecting wellbore integrity, establishing an evaluation index system and processing evaluation indicators to determine failure probability and impact consequences. The resulting risk value can be divided into different areas using the “as low as reasonably practicable principle” or a risk matrix graph. However, due to the complexity of the factors involved and the subjectivity of risk classification rules, there are still challenges in promoting the evaluation model and reducing errors in the evaluation results. China should actively promote interdisciplinary integration and respond to the call for “dual carbon goals” to break through the current bottleneck in wellbore integrity research. This can be achieved by promoting the development of quantitative wellbore integrity risk assessment methods, developing supporting evaluation software based on big data, and by tackling the integrity challenges faced by different types of wells and promoting the development of wellbore integrity discipline.
A novel properties of rice bran: rice bran supplement alleviates chronic restraint stress-induced depression-like behaviors in mice
Authors: Um Min Young , Kim Minji , Yoon Minseok , Cho Suengmok 
Published: September 2023

Abstract

Depression is emerging as a social and health-related issue in many countries. Rice bran supplement (RBS) possesses a variety of biological properties; however, its potential antidepressant effects have not been previously reported. This study investigated the antidepressant effects of RBS in a mouse model of chronic restraint stress (CRS)-induced depression. RBS (250, 500, and 1000 mg/kg) was administered to mice subjected to CRS for 5 weeks. RBS significantly improved depressive symptoms in CRS-exposed mice, as evidenced by increased sucrose preference and reduced immobility time. It reduced serum corticotropin-releasing hormone, adrenocorticotropic hormone, and corticosterone. Additionally, RBS downregulated the expression of glucocorticoid receptor and FK506 binding protein 5 and upregulated the ERK-CREB-BDNF pathway in the prefrontal cortex and hippocampus. Furthermore, RBS increased serotonin, dopamine, and norepinephrine levels and decreased monoamine oxidase mRNA and protein levels in the brain. Thus, RBS administration could be a promising therapeutic approach to treating chronic stress-induced depression.
Quality of parent-child interaction in underserved migrant areas in Kyrgyzstan: a pilot study
Authors: Rim Dahae , Shin Hyunsook , Shon Soonyoung , Ma Hyunhee , Muratbekova Medina , Akimbaev Erlan Muratovich , Babalieva Zamira Buzurmanovna , Djumaeva Nuraiym Talapovna , Tentieva Aijamal Ashimbekovna 
Published: September 2023

Abstract

Background
After societal change in Kyrgyzstan, the pattern of parent-child interaction in the changing parenting culture is an important factor influencing the positive development of Kyrgyz children. This study is aim to assess the quality of parent-child interactions in Kyrgyzstan by analyzing the interaction patterns and playfulness of children during free play at home.
Methods
This was a descriptive pilot study using video-recorded observations to explore parent-child interactions. The Dyadic Parent-Child Interaction Coding System and a playfulness instrument were used to assess the patterns and quality of the interaction. A total of 20 dyads of children aged 24 to 58 months and their parents, living in migrant communities of Kyrgyzstan, participated in this study.
Results
Major parent-child interaction patterns included 731 turns of parent-child dyads during 1040 episodes. Verbal as well as nonverbal behaviors of parents were observed while interacting with their children. Parents used direct and indirect commands most frequently, while praise was used the least in interactions. Children frequently used compliance as well as noncompliance when they interacted with their parents. Children had low playfulness scores while interacting with their parents. Cognitive spontaneity was the component with the lowest score among all subdomains of playfulness.
Conclusion
Future studies are recommended to develop strategies to facilitate parents’ active interaction with their children, promote children’s playfulness, and improve the quality of their mutual interaction.
Identifying novel radioprotective drugs via salivary gland tissue chip screening
Authors: Piraino Lindsay R. , Chen Chiao Yun , Mereness Jared A. , Dunman P. M. , Ovitt Catherine , Benoit Danielle S.W. , DeLouise Lisa A. 
Published: September 2023

Abstract
During head and neck cancer treatment, off-target ionizing radiation damage to the salivary glands commonly causes a permanent loss of secretory function. Due to the resulting decrease in saliva production, patients have trouble eating, speaking and are predisposed to oral infections and tooth decay. While the radioprotective antioxidant drug Amifostine is FDA approved to prevent radiation-induced hyposalivation, it has intolerable side effects that limit its use, motivating the discovery of alternative therapeutics. To address this issue, we previously developed a salivary gland mimetic (SGm) tissue chip platform. Here, we leverage this SGm tissue chip for high-content drug discovery. First, we developed in-chip assays to quantify glutathione and cellular senescence (β-galactosidase), which are biomarkers of radiation damage, and we validated radioprotection using WR-1065, the active form of Amifostine.
Other reported radioprotective drugs including Edaravone, Tempol, N-acetylcysteine (NAC), Rapamycin, Ex-Rad, and Palifermin were also tested to validate the ability of the assays to detect cell damage and radioprotection. All of the drugs except NAC and Ex-Rad exhibited robust radioprotection. Next, a Selleck Chemicals library of 438 FDA-approved drugs was screened for radioprotection. We discovered 25 hits, with most of the drugs identified exhibiting mechanisms of action other than antioxidant activity. Hits were down-selected using EC50 values and pharmacokinetic and pharmacodynamic data from the PubChem database. This led us to test Phenylbutazone (anti-inflammatory), Enoxacin (antibiotic), and Doripenem (antibiotic) for in vivo radioprotection in mice using retroductal injections. Results confirm that Phenylbutazone and Enoxacin exhibited radioprotection equivalent to Amifostine. This body of work demonstrates the development and validation of assays using a SGm tissue chip platform for high-content drug screening and the successful in vitro discovery and in vivo validation of novel radioprotective drugs with non-antioxidant primary indications pointing to possible, yet unknown novel mechanisms of radioprotection.
Healthcare service use in paediatric inflammatory bowel disease: a questionnaire on patient and parent care experiences in Germany
Authors: Boerkoel Aletta , Tischler Luisa , Kaul Kalina , Krause Heiko , Stentzel Ulrike , Schumann Stefan , Berg Neeltje , Laffolie Jan 
Published: September 2023

Abstract
Background
Paediatric inflammatory bowel disease (IBD) patients require chronic care over the lifespan. Care for these patients is complex, as it is adapted for childrens’ life stages and changing disease activity. Guideline based care for this patient group recommends a multidisciplinary approach, which includes in addition to paediatric gastroenterologists nutritional and psychological care services. For PPIBD patients, a discrepancy between available guideline-based multidisciplinary care and actual care has been found from the provider side, but to what extent patients experience this is unclear.
Objectives
To identify which healthcare services were used and whether socio-demographic, geographic or disease related factors have an influence on health service utilisation.
Methods
A standardised questionnaire (CEDNA) was distributed amongst parents of children aged 0-17 diagnosed with PIBD and adolescents (aged 12-17) with an PIBD. Items related to health service use were analysed, these included specialist care, additional care services, reachability of services and satisfaction with care. Logistic regression models on additional service use were calculated. Service availability and reachability maps were made.
Results
Data was analysed for 583 parent and 359 adolescent questionnaires. Over half of the respondents had Crohn’s Disease (CD, patients n=186 parents n=297). Most patients and parents reported their paediatric gastroenterologist as their main care contact (patients 90.5%; parents 93%). Frequently reported additional services were nutritional counselling (patients 48.6%; parents 42.2%) and psychological counselling (patients 28.1%; parents 25.1%). Nutritional counselling was more frequently reported by CD patients in both the patient (OR 2.86; 95%CI 1.73-4.70) and parent (OR 3.1; 95%CI 1.42-6.71) sample. Of the patients, 32% reported not using any additional services, which was more likely for patients with an illness duration of less than one year (OR 3.42; 95%CI 1.26-9.24). This was also observed for the parent population (OR 2.23; 95%CI 1.13-4.4).
The population-based density of specialised paediatric gastroenterologists was not proportionate to the spatial distribution of patients in Germany, which may have an influence on access.
Conclusions
Parents and children reported highly specialised medical care. Multidisciplinary care offers do not reach the entire patient population. Access to multidisciplinary services needs to be ensured for all affected children.
Risk factors for hip dislocation in spastic cerebral palsy
Authors: Liu Gang , Bai Huizhong , Deng Bowen , Yu Ruiqin , Jiao Yong , Hu Chuanyu , Ren Jingpei , Zhao Yi , Xu Lin , Mu Xiaohong 
Published: September 2023

Abstract

Background and objectives:Hip dislocation is a prevalent occurrence among children afflicted with spastic cerebral palsy. It has the potential to induce impairment of function, and a decline in the quality of life. Early prevention and management of hip dislocation remains an intricate problem. Our objective is to elucidate the risk factors influencing hip dislocation in children with spastic cerebral palsy.Methods:We included children with spastic cerebral palsy who were admitted to Dongzhimen Hospital, Beijing University of Chinese Medicine between January 2016 and January 2023. Participants' comprehensive clinical information, encompassing aspects such as gender, age, gestational age, birth weight, Gross Motor Function Classification System (GMFCS) level, and age of first standing, could be meticulously retrieved from medical records. All participants underwent pelvic X-ray examination. The severity of hip dislocation was assessed through the meticulous calculation of the Migration Percentage (MP) of the femoral head. Meanwhile, Acetabular Index (AI) and Neck-Shaft Angle (NSA) were obtained. Correlation analysis and multiple linear regression analysis were performed in the subsequent process.Results:A total of 291 patients (206 males and 85 females) fulfilled the inclusion criteria and were subsequently included in the analytical scope. The mean age was 8.3 years, ranging from 2 to 16 years. Correlation analysis showed that gender, age, gestational age, and birth weight were not related to MP (p> 0.05). Multiple linear regression analysis revealed that GMFCS level (p< 0.001), AI (p< 0.001), NSA (p< 0.001), and age of first standing (p< 0.001) bore the stature of independent risk factors for MP.Conclusions:Our finding has revealed that GMFCS level, AI, NSA, and age of first standing are independent risk factors for the progression of MP in spastic cerebral palsy children. This study provided a new insight for the anticipation of hip dislocation.
Effects of gastroesophageal reflux disease on adverse pregnancy outcomes: a Mendelian randomization study
Authors: Wang Haihong , Lu Pinpin , Zhang Xiaowei , Jin Cuiping , Wang Yongfang , Yu Qiulan , Zhen Meng , Zhu Liling , Zhu Xiaojie , Zhang Yanhua 
Published: September 2023

Abstract
Background
More and more studies have shown that gastroesophageal reflux disease (GERD) is negatively associated with adverse pregnancy outcomes (APOs), including spontaneous abortion, gestational diabetes, pre-eclampsia or eclampsia, premature rupture of membranes, premature separation of the placenta, and postpartum hemorrhage. Nevertheless, the causal relationship between the two is not clear. The study aimed to evaluate the causal relationship between GERD and APOs.
Methods
Based on published genome-wide association studies, two-sample Mendelian randomization (MR) analysis was used to infer the causal relationship between GERD and APOs, in which the fixed-effects inverse variance weighting (IVW) method was the primary method. Various methods were conducted for sensitivity analysis. First, Cochran's Q test assessed heterogeneity among individual SNP estimates. Secondly, MR Egger addressed the pleiotropy effect. Third, a leave-one-out sensitivity analysis was performed to determine whether a single SNP was responsible for the results. Fourth, the funnel plot and forest plot are used to show the pleiotropy directly.
Results
GERD causally increased the risks of spontaneous abortion (odds ratio (OR) = 1.127, 95% confidence interval (CI) = 1.030–1.233, p = 0.009), gestational diabetes (OR = 1.201, 95% CI = 1.075–1.342, p = 0.001), and pre-eclampsia or eclampsia (OR = 1.183, 95% CI = 1.020–1.372, p = 0.026). No associations were observed for premature rupture of membranes, premature separation of the placenta, or postpartum hemorrhage. No evidence of heterogeneity and directional pleiotropy was detected. The leave-one-out sensitivity analysis revealed that the overall estimates were not disproportionately affected by any individual SNP.
Conclusions
This two-sample MR analysis found that GERD was positively associated with spontaneous abortion, gestational diabetes, and pre-eclampsia or eclampsia.
Perceptions of and Preparedness for Cross-Cultural Care: A Survey of Final-Year Medical Students in Ireland
Authors: O'Brien Lesley , Wassall Nicola , Cadoret Danielle , Petrovic Aleksandra , O’Donnell Patrick , Neville Siobhán 
Published: September 2023

Abstract

Background Migration is increasing globally, and societies are becoming more diverse and multi-ethnic. Medical school curricula should prepare students to provide high-quality care to all individuals in the communities they serve. Previous research from North America and Asia has assessed the effectiveness of medical cultural competency training, and student preparedness for delivery of cross-cultural care. However, student preparedness has not been explored in the European context. The aim of this study was to investigate how prepared final-year medical students in the Republic of Ireland (ROI) feel to provide care to patients from other countries, cultures, and ethnicities. In addition, this study aims to explore students’ experiences and perceptions of cross-cultural care.Methods Final-year medical students attending all six medical schools within the ROI were invited to participate in this study. A modified version of the Harvard Cross-Cultural Care Survey (CCCS) was used to assess their preparedness, skill, training/education, and attitudes. The data were analysed using IBM SPSS Statistics 28.0, and Fisher's Exact Test was employed to compare differences within self-identified ethnicity groups and gender.Results Whilst most respondents felt prepared to care for patients in general (80.5%), many felt unprepared to care for specific ethnic patient cohorts, including patients from a minority ethnic background (50.7%) and the Irish Traveller Community (46.8%). Only 20.8% of final-year students felt they had received training in cross-cultural care during their time in medical school. Most respondents agreed that they should be assessed specifically on skills in cultural competence whilst in medical school (83.2%).Conclusions A large proportion of final-year medical students surveyed in Ireland feel inadequately prepared to care for ethnically diverse patients. Similarly, they report feeling unskilled in core areas of cross-cultural care, and a majority agree that they should be assessed on aspects of cultural competency. This study explores shortcomings in cultural competency training and confidence amongst Irish medical students. These findings have implications for future research and curricular change, with opportunities for the development of relevant educational initiatives in Irish medical schools.
HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA
Authors: Ding WenZhou , Jia Wenbo , Yu Liang , Xu Bin , Feng Yanzhi , Wang Jinyi , Zhu Deming , Xu Chao , Liang Litao , Zhou Yongping , Kong Lianbao 
Published: September 2023

Abstract
Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with a poor prognosis. Extensive research has revealed the significant role of long noncoding RNAs (lncRNAs) in the regulation of tumor development. In this particular study, high-throughput sequencing analysis was used to evaluate the expression levels of lncRNAs in three pairs of HCC tissues and their corresponding noncancerous tissues. Through quantitative real-time polymerase chain reaction (qRT-PCR) analysis and clinicopathological analysis, it was discovered that HNF4A-AS1 was downregulated in HCC tissues. Furthermore, its expression levels were found to be positively correlated with the prognosis of HCC patients. Subsequent in vitro and in vivo functional studies demonstrated that HNF4A-AS1 inhibits the proliferation, invasion, and stemness of HCC cells. Mechanistically, it was observed that HNF4A-AS1 physically interacts with the KH3 domain of PCBP2 through a specific segment (491–672 nt). This interaction facilitates the recruitment of PCBP2 by AIP4, leading to the ubiquitination and subsequent degradation of PCBP2. Furthermore, HNF4A-AS1 was found to regulate the stability of AGR2 mRNA by modulating PCBP2, thereby influencing the malignant phenotype of HCC. Overall, this study elucidates the involvement of the HNF4A-AS1/PCBP2/AGR2 axis in the progression of HCC, thereby identifying a potential therapeutic target for intervention in HCC.
Humidity and Temperature Monitoring in the Atlantic Forest
Authors: DE JESUS THIAGO CAMILO , Ferracioli Laercio 
Published: September 2023

Abstract

This paper presents the realization of a study of monitoring and data analysis using humidity and temperature data loggers in a biodiversity hotspot of the Atlantic Forest in southeastern Brazil. The study was carried out with students from the José Pinto Coelho State School of Elementary and Secondary Education who collected data from their homes located in different regions of the Municipality of Santa Teresa, found 80 km from Vitória, capital of the State of Espírito Santo. It had the participation of 84 students from three classes of the 1st year of high school. It aimed to introduce them to the practice of citizen science, seeking to promote understanding of how they can use accessible technologies to monitor local environmental conditions and contribute to studies on climate change. The study consisted of workshops focusing on the production of data loggers, the importance of preserving the Atlantic Forest, how climate change affects this ecosystem and collecting and analyzing data with data loggers. The results reveal that students were engaged in the proposal of citizen science, showing an understanding of environmental issues, and in the bid to use digital technologies and programming as a tool for data collection and analysis.
Infection Point of Care Tests (POCT) in simulated vignettes can improve the education of Antibiotic Stewardship Programmes. An observational comparative study of Clinicians vs Medical Students
Authors: Singhal Archit , Nurek Martine , Lau Timothy. , Mcentee James , Moore Luke , Mughal Nabeela , Mason Sonia , Vizcaychipi Marcela , Singh Suveer 
Published: September 2023

Abstract

Background
Point of Care Tests (POCTs) offer accurate rapid diagnostics for infections but have not improved antibiotic-free-days. This has been attributed to clinician prescribing behaviour rather than test performance. Hypothesising experience to influence prescribing behaviour, we compared the effect of POCT-use on antibiotic decision-making amongst clinical medical students versus intensive care clinicians.
Methods
In a within- and between groups cohort study, clinicians and students saw four clinical vignettes depicting resolving hospital acquired pneumonia on ICU, after a course of antibiotics. Each vignette comprised clinical and biological data, to create four distinct trajectories at the point of antibiotic decision: “clinical-biological improvement”, “clinical improvement/biological worsening”, “clinical worsening /biological improvement”, “clinical-biological worsening”. Participants made an initial antibiotic decision (stop/continue). Then a polymerase-chain-reaction POCT was offered (accepted/declined). Regardless, a negative POCT result was always subsequently presented. Participants updated their antibiotic decision. Stop decisions were compared between groups pre- and post-POCT.
Results
Eighty-eight students and seventy clinicians responded. Pre-POCT result, students stopped antibiotics significantly less than clinicians (42% vs. 53%, p = 0.007); most markedly in the “clinical improvement/biological worsening” case (36% vs. 73%, p < 0.001). Students and clinicians requested a POCT to assist their judgement with equal frequency (65% vs. 67%, p = 0.650). A negative POCT result raised student stop rates to those of clinicians in all scenarios (70% vs. 67%, p = 0.466); the greatest rise in student stop rate being the “clinical improvement /biological worsening” scenario (p = 0.006).
Conclusion
Infection-detecting POCTs (when negative) improved students’ antibiotic stop rates to the level of experienced clinicians, particularly in cases of clinico-biological trajectorial ambiguity. Utilisation of a POCT result, if negative, can reduce (over)cautious prescribing. Simulated vignettes of clinical infection incorporating POCT diagnostics offer a promising learning tool to improve students’ antimicrobial judgement, and confidence in decision making. Such educational interventions in the medical school curriculum may improve antimicrobial stewardship.