bluuebunny/crossref_metadata_2025_split huggingface dataset:
The choroidal nervous system: a link between mineralocorticoid receptor and pachychoroid
Authors: Leclercq Bastien , Weiner Allon , Zola Marta , Mejlacowicz Dan , Lassiaz Patricia , Jonet Laurent , Gélizé Emmanuelle , Perrot Julie , Viengchareun Say , Zhao Min , Behar-Cohen Francine 
Published: September 2023

AbstractCentral serous chorioretinopathy (CSCR) belongs to the pachychoroid spectrum, a pathological phenotype of the choroidal vasculature, in which blood flow is under the choroidal nervous system (ChNS) regulation. The pathogenesis of CSCR is multifactorial, with the most recognised risk factor being intake of glucocorticoids, which activate both the gluco- and the mineralocorticoid (MR) receptors. As MR over-activation is pathogenic in the retina and choroid, it could mediate the pathogenic effects of glucocorticoids in CSCR. But the role of MR signalling in pachychoroid is unknown and whether it affects the ChNS has not been explored. Using anatomo-neurochemical characterisation of the ChNS in rodents and humans, we discovered that beside innervation of arteries, choroidal veins and choriocapillaris are also innervated, suggesting that the entire choroidal vasculature is under neural control. The numerous synapses together with calcitonin gene-related peptide (CGRP) vesicles juxtaposed to choroidal macrophages indicate a neuro-immune crosstalk. Using ultrastructural approaches, we show that transgenic mice overexpressing human MR, display a pachychoroid-like phenotype, with signs of choroidal neuropathy including myelin abnormalities, accumulation and enlargement of mitochondria and nerves vacuolization. Transcriptomic analysis of the RPE/choroid complex in the transgenic mice reveals regulation of corticoids target genes, known to intervene in nerve pathophysiology, such as Lcn2, rdas1/dexras1, S100a8 and S100a9, rabphilin 3a (Rph3a), secretogranin (Scg2) and Kinesin Family Member 5A (Kif5a). Genes belonging to pathways related to vasculature development, hypoxia, epithelial cell apoptosis, epithelial mesenchymal transition, and inflammation, support the pachychoroid phenotype and highlight downstream molecular targets. Hypotheses on the imaging phenotype of pachychoroid in humans are put forward in the light of these new data. Our results provide evidence that MR overactivation causes a choroidal neuropathy that could explain the pachychoroid phenotype found in transgenic mice overexpressing human MR. In patients with pachychoroid and CSCR in which systemic dysautonomia has been demonstrated, MR-induced choroidal neuropathy could be the missing link between corticoids and pachychoroid.
Surgical management of complicated Descemet’s membrane detachment in corneas without prior endothelial keratoplasty
Authors: Berger Tim , Seitz Berthold , Flockerzi Elias , Suffo Shady , Flockerzi Fidelis A. , Berger Maximilian , Szentmáry Nóra , Daas Loay 
Published: September 2023

Abstract
Purpose
To provide insights into morphologic and functional features of eyes with complicated Descemet's membrane detachment (DMD) and report clinical outcomes after surgical intervention.

Methods
Retrospective study of 18 eyes with complicated DMD between 2010 and 2022. Complicated DMD was defined if any of the following criteria applied: prior penetrating keratoplasty (PKP), corneal thinning, total DMD or persistent DMD after Air/Gas-Descemetopexy. Causes, surgical management, and clinical outcomes were analyzed. Scheimpflug tomography, anterior segment optical coherence tomography (AS-OCT) and histologic examination were performed to characterize corneas with DMD.

Results
Fourteen eyes with prior PKP developed spontaneous DMD after 24.2 ± 12.9 years (range = 18 months – 47 years, median = 25.7 years). Complicated DMD without prior PKP was associated in three eyes after cataract surgery and in one eye after infectious keratitis. In cases with previous PKP, AS-OCT demonstrated rupture of Descemet’s membrane (DM) in five eyes and spontaneous reattachment was found in four eyes within 8 weeks of initial diagnosis, with no rupture of DM in any of the cases. There was no rupture of DM in corneas without previous PKP. After prior keratoplasty, definitive surgical treatment was repeat PKP in 13 eyes and Air/Gas-Descemetopexy in one eye. In corneas without prior keratoplasty, three eyes underwent PKP and one eye Air/Gas-Descemetopexy. Histological examination of two corneal explants revealed a severely thinned graft-host junction and a disrupted DM close to the graft-host junction. Visual acuity improved from 1.80 ± 0.58 logMAR to 0.75 ± 0.69 logMAR after prior PKP and from 1.45 ± 0.65 logMAR to 0.85 ± 1.13 logMAR without prior PKP. The postoperative course was uneventful in 16 of 18 eyes.

Conclusion
PKP is an effective treatment option for complicated DMD, especially in ectatic corneas, whereas Air/Gas-Descemetopexy or Descemet Membrane Endothelial Keratoplasty do not address the primary issue of the curvature anomaly.
Genotyping tool for salmonid gill pox virus (SGPV) obtained from farmed and wild Atlantic salmon (Salmo salar)
Authors: Nylund Are , Kloster-Jensen Thomas , Mohammadi Faezeh , Lagadec Erwan , Plarre Heidrun 
Published: September 2023

AbstractPoxviruses are common viruses found in vertebrate species. In 2006, the first poxvirus associated with salmon, salmonid gill poxvirus (SGPV), was identified during an outbreak of gill disease at a smolt production site in northern Norway and at two marine farms in western Norway. Poxviruses had previously been detected in ayu (Plecoglossus altivelis) and koi carp (Cyprinus carpio). In all three fish species, poxviruses are associated with gill disease. It has not been possible to culture SGPV from Norway, and little is known about its virulence. However, the association between SGPV and gill disease in salmon has shown the need for molecular tools to identify reservoirs and transmission routes. Sequencing the genome of a second isolate of SGPV has made it possible to compare variable regions between two strains of the virus, showing the presence of a large number of variable regions that exhibit both variable numbers of tandem repeats and intra-ORF variation. We present eight regions that are suitable for distinguishing strains of SGPV and determining their phylogenetic relationship, and these were used to compare SGPV isolates obtained from both farmed and wild salmon in fresh and sea water. The prevalence of the virus was found to be higher in wild salmon in rivers than in returning wild salmon collected from traps in Norwegian fjords. Genotyping based on the eight selected variable regions, suggests the presence of geographically distinct isolates in freshwater among both farmed and wild salmon, while SGPV from marine farms shows high local diversity and a wide geographical distribution of similar strains of the virus.
Interlingual live subtitling: the crossroads between translation, interpreting and accessibility
Authors: Alonso-Bacigalupe Luis , Romero-Fresco Pablo 
Published: September 2023

AbstractWhereas prototypical conceptions of translation and interpreting as two separate and distinct entities are still being upheld in different contexts, the professional reality shows a less clear-cut picture. Given the relentless advancement of technological innovation and the important role played by (media) accessibility in society, translation, interpreting and accessibility are in a state of flux, with increasingly blurring boundaries between them. Interpreting is not only concerned with spoken and signed modalities, but also with written target texts, which links it to audio–visual translation. In turn, audio–visual translation is no longer only about dubbing and subtitling films from one language to another. It now covers the provision of intra- and interlingual translation for live programmes and live events for users who have no access to the original version (be it for linguistic, sensory-related or other reasons). Speech-to-text interpreting (STTI), also referred to as live subtitling, is a communication-enabling service that allows the production of written access to live events or programmes for people with and without hearing loss. It thus brings together translation, interpreting and accessibility. The aim of this paper is to introduce STTI for readers who may not be familiar with it and to delve into interlingual live subtitling (ILS), and more specifically to explore the research carried out to date about this new technique, its professional development and the way in which it is being trained.
Context Matters Less Than Leadership in Preventing Unethical Behaviour in International Business
Authors: Antunez Marlond , Ramalho Nelson , Marques Tânia M. G. 
Published: September 2023

AbstractThis study empirically tests a sequential mediation model that links ethical leadership with employees’ unethical behaviour. The corruption index for countries is used as the moderator, because it represents both the instrumental ethical climate and the employee displacement of responsibility embedded in society’s ethical standards. A total of 175 participants comprising 41 teams (134 dyads) across 13 countries participated in a dyadic two-wave survey. The findings show that ethical leadership has an indirect influence on the avoidance of unethical behaviour by reducing the instrumental ethical climate and by negating the displacement of individuals’ responsibility. In addition, the results also show that this process is not sensitive to the countries’ corruption levels. Such findings suggest that organizations are less prone to adjust their ethical standards to the environment than is usually expected. Accordingly, ethical leaders of MNCs may be instrumental in counteracting any corruptive pressure in the social environment, and likewise, non-ethical leaders may be a contributing factor to fostering corrupt organizations in a society that otherwise values ethical principles in business.
Meshing strategies for 3d geo-electromagnetic modeling in the presence of metallic infrastructure
Authors: Castillo-Reyes Octavio , Rulff Paula , Schankee Um Evan , Amor-Martin Adrian 
Published: September 2023

AbstractIn 3D geo-electromagnetic modeling, an adequate discretisation of the modeling domain is crucial to obtain accurate forward responses and reliable inversion results while reducing the computational cost. This paper investigates the mesh design for subsurface models, including steel-cased wells, which is relevant for many exploration settings but still remains a numerically challenging task. Applying a goal-oriented mesh refinement technique and subsequent calculations with the high-order edge finite element method, simulations of 3D controlled-source electromagnetic models in the presence of metallic infrastructure are performed. Two test models are considered, each needing a distinct version of approximation methods to incorporate the conductive steel casings of the included wells. The influence of mesh quality, goal-oriented meshing, and high-order approximations on problem sizes, computational cost, and accuracy of electromagnetic responses is investigated. The main insights of our work are: (a) the applied numerical schemes can mitigate the computational burden of geo-electromagnetic modeling in the presence of steel artifacts; (b) investigating the processes driving the meshing of models with embedded metallic infrastructures can lead to adequate strategies to deal with the inversion of such electromagnetic data sets. Based on the modeling results and analyses conducted, general recommendations for modeling strategies are proposed when performing simulations for challenging steel infrastructure scenarios.
A comprehensive analysis of all-cause and cause-specific excess deaths in 30 countries during 2020
Authors: Alicandro Gianfranco , La Vecchia Carlo , Islam Nazrul , Pizzato Margherita 
Published: September 2023

AbstractThe impact of COVID-19 on mortality from specific causes of death remains poorly understood. This study analysed cause-of-death data provided by the World Health Organization from 2011 to 2019 to estimate excess deaths in 2020 in 30 countries. Over-dispersed Poisson regression models were used to estimate the number of deaths that would have been expected if the pandemic had not occurred, separately for men and women. The models included year and age categories to account for temporal trends and changes in size and age structure of the populations. Excess deaths were calculated by subtracting observed deaths from expected ones. Our analysis revealed significant excess deaths from ischemic heart diseases (IHD) (in 10 countries), cerebrovascular diseases (CVD) (in 10 countries), and diabetes (in 19 countries). The majority of countries experienced excess mortality greater than 10%, including Mexico (+ 38·8% for IHD, + 34·9% for diabetes), Guatemala (+ 30·0% for IHD, + 10·2% for CVD, + 39·7% for diabetes), Cuba (+ 18·8% for diabetes), Brazil (+ 12·9% for diabetes), the USA (+ 15·1% for diabetes), Slovenia (+ 33·8% for diabetes), Poland (+ 30·2% for IHD, + 19·5% for CVD, + 26 1% for diabetes), Estonia (+ 26·9% for CVD, + 34·7% for diabetes), Bulgaria (+ 22·8% for IHD, + 11·4% for diabetes), Spain (+ 19·7% for diabetes), Italy (+ 18·0% for diabetes), Lithuania (+ 17·6% for diabetes), Finland (+ 13·2% for diabetes) and Georgia (+ 10·7% for IHD, + 19·0% for diabetes). In 2020, 22 out of 30 countries had a significant increase in total mortality. Some of this excess was attributed to COVID-19, but a substantial increase was also observed in deaths attributed to cardiovascular diseases and diabetes.
Understanding the mechanisms underlying biological control of Fusarium diseases in cereals
Authors: Petrucci Arianna , Khairullina Alfia , Sarrocco Sabrina , Jensen Dan Funck , Jensen Birgit , Jørgensen Hans Jørgen Lyngs , Collinge David B. 
Published: September 2023

AbstractMany Fusarium species cause serious diseases for cereal cultivation. These include Fusarium head blight and crown rot on wheat and bakanae disease on rice. These represent a major concern both in terms of food security and food safety. The latter is connected with the risk of mycotoxin contamination of grains. Biological control has proven its potential for controlling head blight and crown rot diseases of cereals caused by Fusarium species in a number of studies, and indeed several commercial products are under development. We review current knowledge of the mechanisms underlying biological control with a focus on fungal biocontrol agents, and also include challenges related to co-occurrence of Fusarium species. Several of the established biological control mechanisms (antibiosis, competition, hyperparasitism and induced resistance) can act simultaneously, thus resulting in disease control and, consequently, reduction of mycotoxin contamination. We also review the biological roles of some of the many mycotoxins produced by Fusarium species, and the mechanisms by which they are detoxified by cereal enzymes or by other fungi and how biological control agents (BCAs) can stimulate their degradation. Finally, the effect of biocontrol agents on the resident microbiota, as well as the effect of the resident microbiota on the performances of BCAs, are discussed. New perspectives on the use of biocontrol agents for the management of Fusarium diseases on cereals.
Utilizing straw-derived hemicellulosic hydrolysates by Chlorella vulgaris: Contributing to a biorefinery approach
Authors: Kriechbaum Ricarda , Loaiza Sebastian Serna , Friedl Anton , Spadiut Oliver , Kopp Julian 
Published: September 2023

AbstractWith the growing human population, greenhouse gases and global temperature are increasing calling for sustainable biorefineries to convert low-value side streams into high-value products. In this study, the remaining hemicellulosic sugary waste fraction of a wheat straw biorefinery approach, without any pretreatment, was applied as a medium supplement for Chlorella vulgaris cultivation. Next to oligomeric and monomeric sugars, the waste stream contained hydrolysis by-products, such as furfural, 5-hydroxymethylfurfural and acetic acid. Despite the presence of these growth inhibitors, C. vulgaris cultivation was possible. Addition of 2.5% (v/v) of wheat straw hydrolysate to BG11-medium boosted chlorophyll content in C. vulgaris by 40% compared to photoautotrophically grown cells solely cultivated on defined media. As of now, this is the highest chlorophyll content obtained from a cultivation of C. vulgaris on a medium supplemented with a waste stream. Overall, our results demonstrate that wheat straw hydrolysate increases chlorophyll biosynthesis, improving the nutritional value of C. vulgaris biomass for food and feed applications. Hence, valorization of this hemicellulosic sugary fraction results in an additional high-valued product contributing towards the wheat straw biorefinery.
Moving towards in pouch diagnostics for ostomy patients: exploiting the versatility of laser induced graphene sensors
Authors: McCann Conor , Gilpin Victoria , Scott Cameron , Pourshahidi L. Kirsty , Gill Chris. I. R. , Davis James 
Published: September 2023

AbstractThe development of a 3D printed sensor for direct incorporation within stoma pouches is described. Laser induced graphene scribed on either side of polyimide film served as the basis of a 2 electrode configuration that could be integrated within a disposable pouch sensor for the periodic monitoring of ileostomy fluid pH. The graphene sensors were characterised using electron microscopy, Raman spectroscopy, DekTak profilometry with the electrochemical properties investigated using both cyclic and square wave voltammetry. Adsorbed riboflavin was employed as a biocompatible redox probe for the voltammetric measurement of pH. The variation in peak position with pH was found to be linear over pH 3–8 with a sub Nernstian response (43 mV/pH). The adsorbed probe was found to be reversible and exhibited minimal leaching through repeated scanning. The performance of the system was assessed in a heterogeneous bacterial fermentation mixture simulating ileostomy fluid with the pH recorded before and after 96 h incubation. The peak profile in the bacterial medium provided an unambiguous signal free from interference with the calculated pH before and after incubation (pH 5.3 to 3.66) in good agreement with that obtained with commercial pH probes.Graphical abstract
Assessment of anthropogenic impacts on the radioecological status of the Bakony region, Hungary
Authors: Csordás Anita , Novák Máté , Tóth-Bodrogi Edit , György Péter , Fehérvári Máté , Kovács Tibor 
Published: September 2023

AbstractThe Bakony is one of the most active areas in Hungary. Not only is the region home to several popular hiking destinations, but its industrial activity is also significant. On this basis, it is important to carry out a comprehensive study to assess the radioecological status of the Bakony. In this study, 12 monitoring points were selected to collect environmental samples over three different time periods. The samples were analyzed by gamma- and alpha spectrometry. Although the concentrations of Th-232, Ra-226 and K-40 closely resembled the worldwide averages, that of Po-210 in the vicinity of human activities was elevated.
Personalized subject lines in email marketing
Authors: Defau Laurens , Zauner Alexander 
Published: September 2023

AbstractIn the academic literature, there is a growing stream of publications that address how companies can use insights from behavioral economics in marketing. However, often the question remains if these results can be reproduced in another experimental setting. In this article, we use the work from (Sahni et al., Marketing Science 37:236–258, 2018) to test this thesis. In their paper, (Sahni et al., Marketing Science 37:236–258, 2018) show that adding the first name of the recipient to the subject line of an email increases the performance of email campaigns. But in the last years, this marketing trick has become a common practice in email marketing, and therefore, it might be that the behavior of recipients changed as they got used to it. In our empirical research, we find no indication that using the first name of the recipient in the subject line has a positive effect on opening rates or click-through rates; as such we are not able to reproduce the findings from (Sahni et al., Marketing Science 37:236–258, 2018). However, we do find that using the surname of the recipient has a positive effect on opening rates and click-through rates; an indication that similar marketing techniques still have potential, but that they need to be more creative and surprising.
Prevalence, contributing factors, and interventions to reduce medication errors in outpatient and ambulatory settings: a systematic review
Authors: Naseralallah Lina , Stewart Derek , Price Malcom , Paudyal Vibhu 
Published: September 2023

Abstract
Background
Medication errors are common events that compromise patient safety. Outpatient and ambulatory settings enhance access to healthcare which has been linked to favorable outcomes. While medication errors have been extensively researched in inpatient settings, there is dearth of literature from outpatient settings.

Aim
To synthesize the peer-reviewed literature on the prevalence, nature, contributory factors, and interventions to minimize medication errors in outpatient and ambulatory settings.

Method
A systematic review was conducted using Medline, Embase, CINAHL, and Google Scholar which were searched from 2011 to November 2021. Quality assessment was conducted using the quality assessment checklist for prevalence studies tool. Data related to contributory factors were synthesized according to Reason’s accident causation model.

Results
Twenty-four articles were included in the review. Medication errors were common in outpatient and ambulatory settings (23–92% of prescribed drugs). Prescribing errors were the most common type of errors reported (up to 91% of the prescribed drugs, high variations in the data), with dosing errors being most prevalent (up to 41% of the prescribed drugs). Latent conditions, largely due to inadequate knowledge, were common contributory factors followed by active failures. The seven studies that discussed interventions were of poor quality and none used a randomized design.

Conclusion
Medication errors (particularly prescribing errors and dosing errors) in outpatient settings are prevalent, although reported prevalence range is wide. Future research should be informed by behavioral theories and should use high quality designs. These interventions should encompass system-level strategies, multidisciplinary collaborations, effective integration of pharmacists, health information technology, and educational programs.
Affectivity in mental disorders: an enactive-simondonian approach
Authors: García Enara 
Published: September 2023

AbstractSeveral enactive-phenomenological perspectives have pointed to affectivity as a central aspect of mental disorders. Indeed, from an enactive perspective, sense-making is an inherently affective process. A question remains on the role of different forms of affective experiences (i.e., existential feelings, atmospheres, moods, and emotions) in sense-making and, consequently, in mental disorders. This work elaborates on the enactive perspective on mental disorders by attending to the primordial role of affectivity in the self-individuation process. Inspired by Husserl’s genetic methodology and Simondonian philosophy of individuation, sense-making is described as the process of progressive concretization and structuration of the self-world structures that support the intentionality of conscious experiences. Accordingly, affectivity is described as the force that anticipates a partial self-world coherence in sense-making. Structurally different types of affective experiences are integrated into the genetic picture and, on this basis, a reinterpretation and classification of certain mental disorders, such as schizophrenia, depression, and the anxiety spectrum, is provided. In this way, this work contributes to a phenomenologically informed enactive account of mental disorders as disorders of affectivity.