bluuebunny/crossref_metadata_2025_split huggingface dataset:
L-shaped association between dietary riboflavin intake and Cognitive impairment in older adults:NHANES 2011-2014
Authors: Zhang kai , Cai Tianyi , Han Yu , Gu Zhaoxuan , Xie Jinyu , Hou Zhengyan , Yu Xiaoqi , Gao Yafang , Gao Min , Liu Tianzhou 
Published: April 2023

Abstract
Background Research investigating the correlation between dietary riboflavin intake and cognitive function in older adults is scarce and constrained. Our objective was to investigate the relationship between riboflavin intake levels and cognitive performance in individuals aged 60 years and above in the United States.Methods We analyzed data from 2,255 adults aged 60 years and older who participated in the 2011–2014 National Health and Nutrition Examination Survey (NHANES). The Consortium to Establish a Registry for Alzheimer's Disease test, Digit Symbol Substitution Test, and Animal Fluency Test were used to evaluate cognitive performance. Dietary intake was assessed using the 24-hour recall method, which reflects recent dietary habits of individuals and groups. Logistic regression was used to examine the association between riboflavin intake and cognitive impairment, and restricted cubic spline analysis was also conducted.Results The study included a total of 2,255 patients, with 47.9% being male. The incidence of low cognitive function was 23.8%. The findings showed that high riboflavin intake was associated with a lower risk of cognitive impairment in adults in the United States. Compared to those with the lowest intake, individuals with the highest riboflavin intake had a 32% reduction in the correlation between AFT, DSST, and Z-test low cognitive function (OR: 0.68, 95% CI: 0.49–0.96, P = 0.028), a 47% reduction in the correlation between DSST low cognitive function (OR: 0.53, 95% CI: 0.37–0.77, P = 0.001), and a 44% reduction in the correlation between Z-test low cognitive function (OR: 0.56, 95% CI: 0.39–0.8, P = 0.002). The study also found an L-shaped association between low cognition and riboflavin intake, with an inflection point at approximately 2.984 mg/d.Conclusions Our cross-sectional study supported the negative associations of dietary riboflavin intake with low cognitive function, also showed a L-shaped dose–response relationship with the point of 2.984mg/day.
Psychosocial Risk Assessment at work – an international validation study of the Questionnaire for Psychosocial Risk Assessment (QPRA)
Authors: Dettmers Jan , Stempel Christiane R. , Burakova Marina , Coquin Pierre-Alexandre , Moriano Juan A. 
Published: April 2023

Abstract

Due to the increasing number of mental and behavioral disorders, most countries of the European Union have adopted laws and regulations regarding the prevention of psychological ill-health at work. These regulations include the requirement to systematically assess psychosocial work risks, which demands valid and reliable assessment tools. This study explored the validity of the Questionnaire for Psychosocial Risk Assessment at work (QPRA, Dettmers & Krause, 2020) in French and Spanish. We applied rigorous forward-backward translation procedures and culture-sensitive adaptions to ensure the content validity of this risk assessment tool in the different language contexts. Based on a final sample of 166 French, 107 Spanish, and 4210 German full-time employees, we compared item and scale statistics and used multigroup confirmatory factor analysis to test the factor structure and measurement invariance across languages. Furthermore, we examined the relationships between the assessed job characteristics (job stressors and resources) and indicators of employee-work related (ill-)health (emotional exhaustion and work engagement). Preliminary results indicated the need for revising single items to enhance linguistic usage. For the revised language versions, simple item and scale statistics as well scale correlations with theoretically related outcomes, such as emotional exhaustion and work engagement, provided evidence that the instrument produced reliable and valid measurement scores across language versions. Confirmatory factor analysis (cfa) could only be tested for the German and French language version, but not for the Spanish version. Multiple group cfa supported the assumption of strong measurement invariance of the French and the original German version. Future studies should increase the Spanish sample to attain the final assessment of its validity.
Sodium butyrate mediates the JNK/FasL/caspase-8 signalling pathway to regulate intestinal apoptosis and modulate intestinal flora to alleviate glycinin-induced intestinal injury in Cyprinus carpio
Authors: Li Deng-Lai , Zhu Rui , Yang Zhi-Yong , Li Liang , Qu Zi-Hui , Quan Ya-Nan , Wei Xiao-Fang , Shang Guo-Jun , Wang Hao-Tong , Wu Li-Fang 
Published: April 2023

AbstractThe alleviating effect of Sodium butyrate (SB) on intestinal injuries incurred by glycinin in feed was investigated in common carp. The control group (without glycinin and SB), the Gly group (with glycinin), and the remaining 4 groups were added SB (0.75, 1.50, 2.25, 3.00 g/kg) respectively based on the Gly group. 6 groups of diets were isonitrogenous and isoenergetic, and fish were fed with these 6 diets for eight weeks. The findings revealed that glycinin caused apoptosis in the intestine, up-regulated JNK, caspase-3, Bax, caspase-9, p38, caspase-8 and FasL gene expression in the MI, DI and hepatopancreas, while down-regulating ERK and Bcl-2 apoptotic genes. However, no eminent effect on the PI. In contrast, SB2 and SB3 groups eminently reversed these adverse effects. Dietary glycinin eminently reduced the expression of ZO-1, Claudin3, Claudin7 and Occludin1 genes in the MI and DI. SB2 and SB3 groups eminently up-regulated the expression of ZO-1, Claudin3, Claudin7 and Occludin1 expression levels, thereby improving the function of the tightly connected barrier in the intestine. Dietary glycinin also eminently increased serum levels of D-lactate, diamine oxidase, serotonin and endothelin, leading to intestinal damage and increased intestinal permeability. SB2 and SB3 groups reduced serum levels of D-lactate, diamine oxidase, serotonin and endothelin, regulating intestinal permeability. Glycinin disrupted the morphological structure of the intestine, while the SB2 and SB3 groups increased the height and width of the folds of the intestinal villi, thus maintaining the morphological integrity of the intestine. Dietary glycinin upset the intestinal microecological balance by increasing Proteobacteria abundance while lowering Clostridium and Bacteroidetes abundance. The SB2 and SB3 groups altered the composition and number of dominant taxa while increasing the abundance of Firmicutes and Acidobacteria. In conclusion, SB could inhibit apoptosis of intestinal cells through the JNK/FasL/caspase-8 signalling pathway and up-regulate the expression of intestinal tight junction (TJ) genes, maintain intestinal physical barrier and regulate intestinal flora, thereby alleviating glycinin-induced intestinal damage.
Bleaching threatens positive carbonate budgets on Bahraini reefs
Authors: AlMealla Reem , Edullantes Brisneve , Hepburn Leanne 
Published: April 2023

Abstract
Bleaching events impact coral reef functionality and carbonate budget dynamics, which is reflected in reduced reef framework accretion, hindering reef ability to keep pace with sea level rise projections. Reefs in the Arabian Gulf exist in harsh environmental conditions with seasonal temperatures ranging between 16–36◦C. Despite the high thermal thresholds (~ 35◦C) of corals in this region, extensive bleaching and high coral mortality has been reported regionally in 2017. We quantify reef carbonate budgets at a near shore and an offshore reef site in Bahrain in May 2017 and 2018 to assess the impacts of the 2017 severe bleaching event on the budgetary state. Results indicate an overall decrease in hard coral cover from 14.2 ± 5.5% to 8.5 ± 1.4% and a decline in the net carbonate budget state from 3.6 ± 2.2 to 0.3 ± 0.3 kg CaCO3 m− 2 y− 1 at the shallow nearshore Fasht Al Adhm reef indicating a shift from a positive budgetary state to nearly a collapse, whilst the deeper offshore Reef Bul Thamah has increased positively from 3.7 ± 1.2 to 4.2 ± 0.6 kg CaCO3 m− 2 y− 1. We attribute the decline in the nearshore reef to the bleaching event which took place between June – September 2017, resulting in high coral mortality rates and subsequent reduced framework carbonate production. Predicted warming trends present a threat to the structural integrity of shallow Bahraini reefs, compromising their ability to keep pace with future SLR projections.
Correlation Between External Exposure and Quantified Activity for Patients Undergoing NeT-177LU Therapy
Authors: Barquero Raquel , Villar Carlos , Hurtado Antonio , Andres Carlos , Ruano Ricardo , Torres Ricardo 
Published: April 2023

Abstract
Background: To assess the absorbed dose in red marrow as a critical organ of treatment, the total uptake of 177Lu activity for patients undergoing neuroendocrine tumor (NET) with LUTATERA_177_Lu_therapy was determined from routine external dose survey measurements and total quantification from SPECT-CT images.
Aims: Study the correlation of body activity obtained with image with the activity obtained by means of an external exposure monitor. Optimize the number of measurements necessary to be able to assess the evolution of body activity of each patient with the least discomfort.
Methods: The data of 4 images per cycle for 4 cycles of 3 patients were analyzed. The temporal evolution of Aima(t) whole body activity was estimated by means of a series of image acquisitions with SPECT-CT on days 1, 2, 5 and 7 of each cycle. The external dose at 1 m from the patient was determined with a radiation survey meter, measuring the ambient dose equivalent H* at the same moments as with the SPECT-CT images to determine the evolution of whole body activity Amon(t) determined with a conversion factor from external exposure to activity obtained before the patient cleared activity, that is, in the first minutes after administration, t~0. The correlation between Aima(t) vs Amon(t) was studied by means of a model that estimates the external exposure produced by an activity point equivalent and the study of the distribution pattern of activity of the organs and tissues with the highest uptake. Red marrow doses produced by body activity are estimated using the OLINDA software.
Results: The value of Amon(t) obtained from the administered activity (t~0) is 53%, 57% and 75% of that obtained by quantifying the activity with imaging Aima(t) for patients 1, 2 and 3, respectively. The distribution of activity in the first moments after administration presents a more superficial uptake pattern than that which occurs in the days following this administration, formed mostly in very internal organs such as the liver, kidneys and spleen. The red marrow doses obtained for the 3 patients are 0.92, 1.29 (patient with only one kidney) and 0.58 Gy, respectively.
Conclusion: The red marrow dose of patients undergoing NET with Lu-177 can be estimated from external measurements with radiation survey meter provided that at least, (to reduce patient discomfort to a minumum), one SPECT-CT image is available, acquired over days 1 to 5 after administration.
Urban people’s preferences for life-sustaining treatment or artificial nutrition and hydration in advance decisions
Authors: Wu Yi-Ling , Lin Tsai-Wen , Yang Chun-Yi , Shen Pei-Han , Liu Ching-Nu , Wang Samuel Shih-Chih , Huang Sheng-Jean 
Published: April 2023

Abstract
Objectives This study investigated the preferences of AD, consistency, and differences in LST and ANH preferences, and factors affecting LST and ANH selection among urban residents.Research Methodology: A retrospective observational design and Convenience sampling were utilized in this study. Data of 2337 individuals with legal ability who were at least 20 years old and attended the ACP consultations from January 5 to January 6, 2020, were retrieved from the electronic records.Setting: Taiwan's Patient Right to Autonomy Act was put into effects in 2019 and allowed the signing of advance decisions (AD) through advance care planning (ACP). Withhold and withdrawal from life-sustaining treatment (LST) or artificial nutrition and hydration (ANH) treatment are now allowed for anyone to be in a condition of irreversible coma, vegetative state, severe dementia, or unbearable pain.Main Outcome Measures: Preferences of life-sustaining treatment and artificial nutrition/hydration, clinical conditions, differences from participants' preferences, and factors associated with preferenceResults High consistency was found in the willingness of refusing LST and ANH which differed significantly between the terminal diseases and extremely severe dementia. Besides, ANH was widely accepted as a time-limited treatment as well as authorizing health care agent to make decisions on behalf of the patients.Conclusion Significant differences were found in gender, age, and consultation intention in not wishing the family to take responsibility in making decisions. Influential factors involved cultural impacts and demographics.
A Systematic Review and Meta-Analyses on Early-Childhood-Caries Global Data
Authors: Maklennan Anastasia , Esteves-Oliveira Marcella , Weirichs Richard Johannes , Campus Guglielmo 
Published: April 2023

Abstract
The present study systematically reviewed and provided a meta-analysis on early childhood caries (ECC) global prevalence and its association with socioeconomic indicators, both geographical and regarding unemployment rate, national income as well as income inequalities. Studies published from 2011 to 2022 from PubMed, Scopus and Embase were retrieved by ad hoc prepared search strings. Cross-sectional and cohort studies reporting the prevalence and experience of early childhood caries in children under 71 months in urban or rural communities were included. Primary outcomes of the included studies were the prevalence and experience of ECC. The meta-analyses were conducted for both overall ECC prevalence and experience stratified by country of publication as well as measures of socioeconomic indicators (geographical area, gross national income (GNI), wealth inequality within a nation index (Gini), unemployment rate) using a random effects model using STATA 17®. One hundred publications reporting ECC data from 49 countries (published from 2011–2022) were included and summarized by meta-analysis. The lowest prevalence was reported in Japan (20.6%) and Greece (19.3%). The global estimated random-effect pooled prevalence of ECC was 59.05%, while the estimated overall pooled caries experience (mean dmft) was 3.41 ± 2.40, ECC prevalence was 22.11%, 14.14%, 15.37%, 20.27% and 28.10% for countries with GNI < 5.000USD, > 5.000 < 10.000USD, > 10.000 < 20.000USD, > 20.000 < 40.000 and > 40.000 respectively. For the four different categories of life expectancy (53–70, > 70–75, > 75–80, > 80), the highest pooled prevalence of ECC was in the age category > 75–80 (39.41%) and for the unemployment rate, it was in the category of medium unemployment rate (60.38%). Within the limitations of this study, results from 49 different countries reported a wide range of ECC prevalence. These reports indicated persisting high worldwide distribution of the disease. Both ECC prevalence and experience were associated with geographical areas and GNI.
A Brazilian nationwide multicenter study on Deficiency of Deaminase-2 (DADA2)
Authors: Melo Adriana , de Carvalho Luciana Martins , Ferriani Virginia Paes Leme , Cavalcanti André , Appenzeller Simone , Oliveira Valéria Rossato , Neto Herbert Chong , Rosário Nelson Augusto , Poswar Fabiano de Oliveira , Guimaraes Matheus Xavier , Kokron Cristina Maria , Maia Rayane Elias , Silva Guilherme Diogo , Keller Gabriel , Ferreira Mauricio Domingues , Vasconcelos Dewton Moraes , Toledo-Barros Myrthes Anna Maragna , Barros Samar Freschi , Sales Nilton , Krieger Marta Helena , Kalil Jorge , Mendonça Leonardo Oliveira 
Published: April 2023

Abstract
Introduction: The deficiency of ADA2 (DADA2) is a rare autoinflammatory disease provoked by mutations in the ADA2 gene inherited in a recessive fashion. Up to this moment there is no consensus for the treatment of DADA2 and anti-TNF is the therapy of choice for chronic management whereas bone marrow transplantation is considered for refractory or severe phenotypes. Data from Brazil is scarce and this multicentric study reports 18 patients with DADA2 from Brazil.
Patients and Methods: This is a multicentric study proposed from the Center for Rare and Immunological Disorders of the Hospital 9 de Julho - DASA, São Paulo - Brazil. Patients of any age with a confirmed diagnosis of DADA2 were eligible for this project and data on clinical, laboratory, genetics and treatment were collected.
Results: 18 patients from 9 centers are reported here. All patients had disease onset at the pediatric age (median of 5 years) and most of them from the state of São Paulo. Vasculopathy with recurrent stroke was the most common phenotype but atypical phenotypes compatible with ALPS-like and Common Variable Immunodeficiency (CIVID) was also found. All patients carried pathogenic mutations in ADA2 gene. Acute management of vasculitis was not satisfactory with steroids in many patients and all those who used anti-TNF had favorable responses.
Conclusion: The low number of patients diagnosed with DADA2 in Brazil reinforces the need for disease awareness for this condition. Moreover, the absence of guidelines for diagnosis and management is also necessary to guide diagnosis and treatment of this disorder.
96 kN-sec Endurance Test of the R-200 Low Power Hall Thruster
Authors: Lev Dan , Franco Daniel Katz , Zimmerman Raul , Tordjman Moshe , Auslender Boaz , Epstein Oren 
Published: April 2023

Abstract
The R-200 low power Hall thruster unit passed a 96 kNs endurance test in which it operated at one operating point of 250 W (275 V) while anode mass flow rate adjusted over time to maintain constant power. The test was performed at Rafael, while the initial performance validation was conducted at ESTEC. At the end of the endurance test the thruster exhibited nearly unchanged performance and did not reach its end-of-life. Throughout the endurance test performance was characterized 5 times in the 100-250 W discharge power range, ceramic channel profile was measured 6 times to assess the erosion rate, thrust was continuously tracked multiple times a day, an ignition test was conducted after 60 kNs to assess continuous operation impact on ignition capability, and sensitivity to magnetic field changes was checked twice (12 kNs and 65 kNs). Two notable events occurred during the test – a cathode keeper breach and a ceramic channel breach. The keeper electrode was replaced, and cathode position adjusted. following the ceramic channel breach the thruster continued to operate regularly, and with no performance degradation, even after the inner pole was exposed to the plasma discharge. The thruster generated a constant thrust of 13 mN throughout the entire test while the Isp decreased from 1,250 sec at the beginning of life to 1,160 sec at the end of test. Performance degradation of less than 10% was spotted at all operating points in the 100-250 W discharge power range throughout the experiment. The ignition test validated 300 successful thruster ignition cycles. Using channel profile geometry data a simple semi-empirical erosion model was constructed to predict possible breaching points and allow for an improved future channel design. The information gathered during this endurance test campaign was used to redesign the cathode keeper and inner ceramic channel profile. A subsequent test of the improved thruster unit design showed an expected lifetime of over 200 kNs.
Prognostic characteristics and immune infiltration analysis of Kidney Renal Clear Cell Carcinoma based on m6A- associated lncRNA
Authors: Chen Chen , Xiong Xi , Yang Jun , Zhang Wei , Wang Xiong , Peng Min , Li Lili , Luo Pengcheng 
Published: April 2023

Abstract
Background: The m6A mutation may have a significant effect on non-coding RNA metabolism, ultimately contributing to tumor growth and metastasis. However, the mechanism of m6A-related lncRNAs in Kidney Renal Clear Cell Carcinoma (KIRC) has not yet been elucidated.
Methods: Herein, we used transcriptional and clinical data from the TCGA to conduct the comprehensive analysis of m6A-related prognostic lncRNAs in KIRC. Twelve lncRNAs correlated with m6A were shown to be strongly associated with clinical prognosis. We utilized consensus clustering to classify these prognostic lncRNAs into two groups based on their expression levels in tumor tissue. The cluster B was significantly associated with higher expression levels of m6A-related prognostic lncRNAs and shorter patient survival. Subsequently, seven m6A-related lncRNAs were recognized to structure a predictive model, which were strongly correlated with tumor prognosis and could be employed as the independent prognostic factor. In the analysis of clinical correlation, it was shown that risk score was remarkably related with tumor metastasis. Finally, our analysis established correlation between infiltrating immune cells and m6A-related lncRNAs in KIRC patients.
Results: As a result, we investigated m6A-related lncRNAs and the prognosis of KIRC to reveal the relationship between the 530 clinical samples and 611 transcriptome data showed that the prognostic model established by 12 high-risk lncRNAs can predict KIRC. The prognosis of patients, among which seven key m6A-related lncRNAs: AC005261.3, AC024060.2, AC079174.2, AL139123.1, AL355388.1, CD27-AS1, and DGUOK-AS1, were significantly associated with the overall survival and prognosis of KIRC.
Conclusion: Overall, our results imply that m6A-related prognostic lncRNAs could be underlying biomarkers for immunotherapy in KIRC.
A Deep Unsupervised Residual - Convolutional Auto-Encoder: Multifocus Image Fusion based on Local Binary Pattern
Authors: M Gayathri Devi , S Akila I 
Published: April 2023

Abstract
Image fusion has become a frequently used approach for improving the visual awareness for various applications such as medical diagnosis, surveillance, military , computer vision, robotics, enhanced vision systems, biometrics, and remote sensing and many. From literature, most of the Image fusion technique requires sophisticated pre-processing and post-processing steps to create image patches to train the network, generate the focus map, consistency verification but the fused image results in blocking artifacts and smoothening effects. This paper focuses on simple novel Deep Unsupervised Residual-Convolution Auto-Encoder Network (R-CAEN) to address these limitations. R-CAEN is trained with proposed Euclidean Loss Function in keras-tensorflow platform. The encoder-decoder model learns to extracts the deep features from the source images in a residual approach. A normalized Local Binary Pattern (LBP) codes for the corresponding encoder features are calculated for fusion. The decoder decodes the fused features and the fused image is evaluated with the objective measures: Correlation Coefficient, Peak Signal to Noise Ratio, Measure of Structural Similarity Index, Entropy and Visual Information Fidelity. The subjective and objective analysis of R-CAEN is compared with six existing methods and the results shows that the performance of R-CAEN outperforms the existing methods.