bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke
Authors: Zheng Siyi , Banerji Rohin , LeBourdais Rob , Zhang Sue , DuBois Eric , O’Shea Timothy , Nia Hadi T. 
Published: September 2023

AbstractResidual mechanical stresses in tissues arise during rapid differential growth or remodeling such as in morphogenesis and cancer. These residual stresses, also known as solid stresses, are distinct from fluid pressures and dissipate in most healthy adult organs as the rate of growth decreases. However, studies have shown that residual stresses remain substantially high even in mature, healthy brains. The genesis and consequences of these mechanical stresses in a healthy brain, and in aging and disease remain to be explored. Here, we utilized and validated our previously developed method to map residual mechanical stresses in the brains of mice in three different age groups: 5-7 days, 8-12 weeks, and 22 months old. We found that residual solid stress increases rapidly from 5-7 days to 8-12 weeks in mice, and remains high even in mature 22-month-old mice brains. Three-dimensional mapping of the residual stresses revealed an increasing trend from anterior to posterior in coronal sections of the brain. Since the brain is rich in negatively charged hyaluronic acid, we evaluated the contribution of charged extracellular matrix (ECM) constituents in maintaining solid stress levels. We found that lower ionic strength leads to elevated solid stresses, a finding consistent with the unshielding effect of low ionic strength and the subsequent expansion of charged ECM components. Lastly, we demonstrated that hemorrhagic stroke, accompanied by loss of cellular density, resulted in decreased levels of residual stress in the murine brain. Our findings contribute to a better understanding of the spatiotemporal alteration of residual solid stresses in healthy and diseased brains, a crucial step toward uncovering the biological and immunological consequences of this understudied mechanical phenotype in the brain.Significance StatementWhile emerging evidence highlights the importance of solid stresses in embryogenesis and tumor growth, the genesis and consequences of residual solid stresses in the adult normal brain remain poorly understood. Understanding the spatiotemporal distribution and alteration of the residual solid stresses as the brain ages and is impacted by neuropathologies, such as a stroke, will elucidate the biological and immunological consequences of maintaining these stresses. This study suggests solid stress could serve as a potential biomarker in aging and diseases associated to the brain.
Harnessing the endogenous Type I-C CRISPR-Cas system for genome editing inBifidobacterium breve
Authors: Han Xiao , Chang Lulu , Chen Haiqin , Zhao Jianxin , Tian Fengwei , Paul Ross R. , Stanton Catherine , van Sinderen Douwe , Chen Wei , Yang Bo 
Published: September 2023

AbstractBifidobacterium breve, one of the main bifidobacterial species colonizing the human gastrointestinal tract in early life, has received extensive attention for its purported beneficial effects on human health. However, exploration of the mode of action of such beneficial effects exerted byB. breveis cumbersome due to the lack of effective genetic tools, which limits its synthetic biology application. Given the widespread presence of endogenous CRISPR-Cas systems inB. breve, the current study developed an endogenous CRISPR-based gene editing toolkit for genetic manipulation ofB. breve. Deletion of the gene coding uracil phosphoribosyl-transferase (upp) was achieved in two differentB. brevestrains using this system. In addition, translational termination of uracil phosphoribosyl-transferase was successfully achieved inB. breveFJSWX38M7 by single-base substitution of theuppgene and insertion of three stop codons. The gene encoding linoleic acid isomerase (bbi) inB. breve, being a characteristic trait, was deleted after plasmid curing, which rendered it unable to convert linoleic acid into conjugated linoleic acid, demonstrating the feasibility of successive editing. This study expanded the gene manipulation toolkit ofB. breveand provides a reference for functional genome editing and analysis using an endogenous CRISPR-Cas system inBifidobacterium.ImportanceThe lack of effective genetic tools forBifidobacterium breveis an obstacle to studying the molecular mechanisms of its health-promoting effects, hindering the development of next-generation probiotics. Here, we introduce a gene editing method based on the endogenous CRISPR-Cas system, which can achieve gene deletion, single base substitution, gene insertion and continuous gene editing inB. breve. This study will promote the excavation of functional genes and elucidation of molecular mechanisms ofB. breve.
Shedding Light on the D1-Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D1and D5Receptors
Authors: Rosier Niklas , Mönnich Denise , Nagl Martin , Schihada Hannes , Sirbu Alexei , Konar Nergis , Reyes-Resina Irene , Navarro Gemma , Franco Rafael , Kolb Peter , Annibale Paolo , Pockes Steffen 
Published: September 2023

AbstractDopamine D1-like receptors are the most abundant type of dopamine receptors in the central nervous system and, even after decades of discovery, still highly interesting for the study of neurological diseases. We herein describe the synthesis of a new set of fluorescent ligands, structurally derived from D1R antagonist SCH-23390 and labeled with two different fluorescent dyes, as tool compounds for the visualization of D1-like receptors. Pharmacological characterization in radioligand binding studies identified UR-NR435 (25) as a high-affinity ligand for D1-like receptors (pKi(D1R) = 8.34, pKi(D5R) = 7.62) with excellent selectivity towards D2-like receptors. Compound25proved to be a neutral antagonist at the D1R and D5R in a Gsheterotrimer dissociation assay, an important feature to avoid receptor internalization and degradation when working with whole cells. The neutral antagonist25displayed rapid association and complete dissociation to the D1R in kinetic binding studies using confocal microscopy verifying its applicability for fluorescence microscopy. Moreover, molecular brightness studies determined a single-digit nanomolar binding affinity of the ligand, which was in good agreement with radioligand binding data. For this reason, this fluorescent ligand is a useful tool for a sophisticated characterization of native D1receptors in a variety of experimental setups.
Market mavenism, tourists’ co-creation experience, loyalty, vaxication intention: mediating role of travel incentives in the post-COVID-19 environment
Authors: Abbas Alhamzah F. , Khwaja Muddasar Ghani , Abbasi Amir Zaib , Hameed Athar 
Published: September 2023

Purpose
The purpose of this study is to examine the relationships between market mavenism, tourists’ cocreation experience, loyalty and the mediating role of travel incentives in the post-COVID-19 tourism environment in the context of vaxication intentions in Turkey.

Design/methodology/approach
This study used covariance-based structural equation modeling to empirically test the proposed hypotheses. A total of 348 respondents participated in the survey.

Findings
The findings of this study support the assumption that market mavenism (MM) engage in cocreating and sharing travel experiences (CCTE). Furthermore, the study reveals that market mavens tend to demonstrate loyalty (LTY) toward service providers when engaging in cocreation with travel industry professionals. In addition, the study establishes the significant mediating effect of travel incentives (TI) between MM and vaxication intention (VI).

Research limitations/implications
The study uses the theory of planned behavior to examine tourists’ intentions for vaxication and the psychological factors influencing their decisions, while also using the macro–micro theory to explore industry-level factors like market mavens and customer engagement, leading to a comprehensive understanding of COVID-19 vaccination and tourism behavior. Further research is needed to address limitations such as country diversity, multiple locations and service providers, online behavior analysis, authenticity perception and identification of market mavens’ personality traits and travel preferences.

Originality/value
This study contributes to the scholarly literature in several ways. First, it explores the influence of market mavens on tourism experience cocreation and customer loyalty during the postpandemic era. Second, it empirically examines the mediating role of travel incentives, adding to the understanding of market mavens and vaccination intentions. Lastly, the study addresses the implications during and after the COVID-19 for managers and service providers in the tourism industry.
Pro-environmental values’ and consumer behavior in base of the pyramid market: Ghana
Authors: Naatu Felicia , Alon Ilan , Amoako George Kofi , Mornah Dekuwmini 
Published: September 2023

Purpose
This study aims to fill the gap on proenvironmental behavior studies among consumers in bottom of the pyramid (BOP) market by examining the relationship between values, beliefs and norms among Ghanaian consumers.

Design/methodology/approach
A sample of 324 Ghanaian consumers (responses rate of 64%) was used to estimate the model. The data was analyzed using maximum likelihood robust approach of Lavaan package for structural equation modeling in R.

Findings
The findings show that there is no significant relationship between values and the new ecological worldview, which also does not affect awareness of environmental consequences. However, awareness of consequences, likely based on personal experiences, significantly impacts perceived ability to reduce threats to the environment. Ghanaian consumers are mainly influenced by personal experiences with local environmental consequences that affect their perceived ability to reduce threats to their environment and their willingness to engage in proenvironmental behavior. The study supports the argument that proenvironmental behavior is the result of complex decision-making that might be influenced by a country’s economic situation, infrastructure, culture and institutions.

Research limitations/implications
This study focuses on a single country in Africa. More studies are needed among other base of the pyramid countries, and in comparison to developed countries’ consumers.

Originality/value
The study adds to the limited knowledge regarding sustainable consumption in the neglected context of the bottom of the pyramid market.
A consumer perspective of AI certification – the current certification landscape, consumer approval and directions for future research
Authors: Blösser Myrthe , Weihrauch Andrea 
Published: September 2023

Purpose
In spite of the merits of artificial intelligence (AI) in marketing and social media, harm to consumers has prompted calls for AI auditing/certification. Understanding consumers’ approval of AI certification entities is vital for its effectiveness and companies’ choice of certification. This study aims to generate important insights into the consumer perspective of AI certifications and stimulate future research.

Design/methodology/approach
A literature and status-quo-driven search of the AI certification landscape identifies entities and related concepts. This study empirically explores consumer approval of the most discussed entities in four AI decision domains using an online experiment and outline a research agenda for AI certification in marketing/social media.

Findings
Trust in AI certification is complex. The empirical findings show that consumers seem to approve more of non-profit entities than for-profit entities, with the government approving the most.

Research limitations/implications
The introduction of AI certification to marketing/social media contributes to work on consumer trust and AI acceptance and structures AI certification research from outside marketing to facilitate future research on AI certification for marketing/social media scholars.

Practical implications
For businesses, the authors provide a first insight into consumer preferences for AI-certifying entities, guiding the choice of which entity to use. For policymakers, this work guides their ongoing discussion on “who should certify AI” from a consumer perspective.

Originality/value
To the best of the authors’ knowledge, this work is the first to introduce the topic of AI certification to the marketing/social media literature, provide a novel guideline to scholars and offer the first set of empirical studies examining consumer approval of AI certifications.
Deconstructed entrepreneurial orientation and export performance: mediating role of differentiation and cost leadership strategy from the developing country context
Authors: Hossain Kamal , Alam Mohammad Nurul , Muwazir Mohd Rizal , Alsiehemy Ali , Azizan Noor Azlinna 
Published: September 2023

PurposeThe aim of this study is to examine the effects of innovativeness (INN), proactiveness, (PRC) and risk-taking (RIT) on the export performance of apparel small and medium-sized enterprises (SMEs) and the role of differentiation and low-cost leadership (LCL) strategies as mediating effects between entrepreneurial orientation (EO) dimensions and the performance of exporting firms. INN, RIT and PRC are considered EO dimensions.Design/methodology/approachA cross-sectional survey was carried out by providing a questionnaire to the owners, directors and senior managers of the apparel SMEs – the primary data of 550 treated by structural equation modeling (SEM) technique for final data analysis.FindingsThe study has revealed the positive dimensional effect of EO on export performance. For the mediation effects of differentiation and LCL, differentiation strategy (DS) positively mediates between INN, PRC and export performance. However, no mediation has been found between RIT and export performance. On the other hand, LCL has found positive effects between INN, RIT and export performance. However, the mediation effect was absent between PRC and export performance.Research limitations/implicationsLimitations/implications- This study has been conducted on only Muslim owners, senior export managers and directors of apparel SMEs in Bangladesh. It has examined the two main competitive strategies as a mediator between EO dimensions and export performance. The findings of this study are based on one country data analysis.Practical implicationsEO, differentiation and low-cost leadership (LCL) strategy are resources and capabilities of an organization to create a competitive advantage to enhance performance. The factors of this research are helpful for SME practitioners.Originality/valueThe direct and indirect effects (differentiation and LCL strategy) of EO dimensions on export performance in an emerging country, i.e. the South-Asia region, is a pioneer study. Therefore, current research has theoretical and managerial implications for the international business and strategic management literature.
PLS-SEM in information systems: seizing the opportunity and marching ahead full speed to adopt methodological updates
Authors: Sabol Misty , Hair Joe , Cepeda Gabriel , Roldán José L. , Chong Alain Yee Loong 
Published: September 2023

PurposeExpanded awareness and application of recent PLS-SEM reporting practices were again called for by Hair (2022) in his PLS 2022 Keynote Address. This paper aims to analyze and extend the application of PLS-SEM in Industrial Management and Data Systems (IMDS) to focus on trends emerging in the more recent 2016–2022 period.Design/methodology/approachA review of PLS-SEM applications in information systems studies published in IMDS and MISQ for the period 2012–2022 identifies and comments on a total of 135 articles. Selected emerging advanced analytical PLS-SEM applications are also highlighted to expand awareness of their value in more rigorously evaluating model results.FindingsThere is a continually increasing maturity of the information systems field in applying PLS-SEM, particularly for IMDS authors. Model complexity and improved prediction assessment as well as other advanced analytical options are increasingly identified as reasons for applying PLS-SEM.Research limitations/implicationsFindings demonstrate the continued use and acceptance of PLS-SEM as a useful alternative research methodology within IS. PLS-SEM is the preferred SEM method in many research settings, but particularly when the research objective is prediction to the population, mediation and mediated moderation, formative constructs are specified, constructs must be modeled as higher-order and for competing model comparisons.Practical implicationsThis update on PLS-SEM applications and recent methodological developments will help authors to better understand and apply the method, as well as publish their work. Researchers are encouraged to engage in more complete analyses and include enhanced reporting procedures.Originality/valueApplications of PLS-SEM for prediction, theory testing and confirmation are increasing. Information systems scholars should continue to exercise sound practice by reporting reasons for using PLS-SEM and recognizing its wider applicability for both exploratory and confirmatory research.
A corporate risk assessment and reporting model in emerging economies
Authors: Blue Ghassem , Faraji Omid , Khotanlou Mohsen , Rezaee Zabihollah 
Published: September 2023

PurposeThe growing business complexity has caused many risks (e.g. operational, financial, reputational, cybersecurity, regulatory and compliance) that threaten companies' sustainability and have received attention from regulators, investors, and businesses. The authors present a model for assessing and reporting corporate risk by examining the indicators underlying corporate risk reporting.Design/methodology/approachA thorough review of the literature and semi-structured interviews with experts were conducted and the fuzzy Delphi technique was used to obtain consensus and screening of risks. The relationships between these risk indicators were recognized, weighted and prioritized by employing a hybrid Decision Making Trial and Evaluation Laboratory Model (DEMATEL) method integrated with Analytic Network Process (ANP) (DEMATEL-ANP [DANP]) approach. Finally, using the Iranian setting of corporate risk reporting, a model was developed to calculate the risk-reporting scores.FindingsThe results indicate that risk disclosure quality is more important than risk disclosures' textual properties and quantity. According to the experts, reporting the key risks that the company faces, management's approach to dealing with these risks and quantifying their impact are more important than the other indicators. The results also show that risk reporting in Iran lacks quantitative and specific information, and most risk disclosures are sticky.Research limitations/implicationsThe data have been prepared and analyzed according to the unique Iranian reporting environment, which should be considered when interpreting the results.Practical implicationsThe results of this research can be used by the regulators of the Stock Exchange Organizations (SEO) to evaluate corporate risk reports and rank companies. Results are also relevant to investors and policymakers to identify companies with poor risk disclosure and to take necessary measures to improve their reporting practices.Social implicationsThis paper contributes to the social and governance literature by presenting the importance of risk reporting in corporate disclosures.Originality/valueThe unique Iranian setting of corporate risk reporting furthers the understanding of risk reporting and thus provides education, policy, practice and research implications for other emerging economies like Iran. Many prior studies focus mainly on the quality of risk disclosure, and other aspects of corporate risk disclosure presented in the study have remained largely overlooked. The corporate risk reporting attributes identified in the study are relevant to the rise of non-financial risks, the textual and qualitative nature of risk reporting and textual risk disclosures.
A shared corporate vision: staff and senior management collaborate for market dominance at a large Saudi hotel
Authors: Borzillo Stefano , Alshahrani Salem 
Published: September 2023

Purpose
The purpose of this study is to uncover the essential conditions for establishing a successful collaboration between the Fairmont Hotel (Makkah) staff and the senior management team to prepare for cocreating a future shared corporate vision.

Design/methodology/approach
This study is an action research project involving senior managers of the Fairmont Hotel (Makkah) and EHL Hospitality Business School (Lausanne, Switzerland). Data were collected from 16 hotel staff members, covering functional/department managers, team leaders, operations supervisors and operational-level employees.

Findings
This study uncovered a series of generic proposals made by the hotel staff, which are prerequisites/conditions for successful collaboration with senior management, to prepare for cocreating a future shared vision.

Practical implications
In response to the staff’s generic proposals, the senior management team proposed practical measures to support continued collaboration between hotel staff and the senior management team. These measures aim to maintain a collaborative approach centered on achieving future common goals and a shared vision to promote sustainable innovation in the services of the Fairmont Hotel (Makkah).

Originality/value
This study is innovative in two respects. First, it demonstrates a strong willingness on the part of senior management and staff to collaborate less vertically, contrary to the cultural norm in Saudi Arabia, known for its strong hierarchical distance. Second, the mutual commitment to more horizontal collaboration is not typical of five-star hotels, which are traditionally vertical and hierarchical.
Operational resilience in light of the war in Ukraine: the disruptive effect of implementing economic sanctions on financial service providers
Authors: Teichmann Fabian Maximilian Johannes , Wittmann Chiara , Sergi Bruno S. 
Published: September 2023

Purpose
The operational resilience of financial service providers is strained to an unprecedented extent following the Russian aggression in the Ukraine and the subsequent implementation of targeted economic sanctions. This paper aims to consider how operational resilience supports financial service providers in implementing sanctions.

Design/methodology/approach
The demand made of financial service providers by economic sanction is considered through the lens of operational resilience. Practical problems for the providers are aligned with economic sanctions policies.

Findings
A well-established system of operational resilience enables financial service providers to meet compliance requirements of economic sanctions with greater ease.

Originality/value
The literature does not credit operational resilience as a systemic capacity of corporations and rather presents it as a specialised feature. In addition, the role of the regulatory bodies is often dismissed despite directly inciting the practical problems faced.