bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Acceptability and Feasibility of a Virtual Mantram Program for Patients with Posttraumatic Stress Disorder and Substance Use Disorders: Mixed Method results
Authors: Hassan Ahmed N. , Ferkul Sean , Agabani Zena , Minami Osamu , Bormann Jill , Foll Bernard Le , Lobo Leah 
Published: March 2023

Abstract
Background: There is a need for expanded options for therapeutic interventions for patients with posttraumatic stress disorder (PTSD) and substance use disorder (SUD). The study aimed to examine evidence for the feasibility, safety, and acceptability of a virtual Mantram Repetition Program for adults with PTSD and SUD.
Methods: This project utilized mixed-method design (explanatory sequential design) to collect quantitative and qualitative data to evaluate the program in terms of its feasibility and acceptability. The program took place over Webex, an encrypted virtual platform. The group ran over 8 weeks, was 90 minutes in length, and facilitated by two individuals per cohort. Each group had 4-5 participants given each group cycle.
The study used the Mantram Repetition Program which is a brief mindfulness based non-tramua focused group intervention.
Results: Out of 43 participants enrolled, 5 people (11.6%) did not commence the program and 8 (18.6%) participants dropped out after commencing the program, resulting 35 completers (81.4% retention rate). Treatment completion and retention were above 70%. Qualitative data explained several aspect of the program’s acceptability including delivery methods, informative material provided and gaining a practical mindful tool to manage symptoms.
Conclusions: This study showed quantitative and qualitative evidence of the Mantram Repetition Program’s feasibility, acceptability and safety to be used with individuals with PTSD-SUD. Although further evaluation of virtual Mantram Program to control group in longitudinal trials is needed to identify how it compares with other interventions in the field.
Clinical trial registration number: NCT05058963, (28/09/2021).
NSF mediates CDC5L nuclear import to promote cell growth and metastasis in hepatocellular carcinoma
Authors: Zhu Hongxu , Wang Yixiu , Zhang Li , Xu Weiqi , Wang Longrong , zhu weiping , Zhao Yiming , Zhang Ti , Wang Lu 
Published: March 2023

Abstract
Intracellular transportation (IT) is dysregulated in tumors. Here, we identified N-ethylmaleimide-sensitive factor (NSF) as one of the IT-associated genes with upregulated expression in hepatocellular carcinoma (HCC). Furthermore, NSF expression is associated with malignant features and poor outcomes of HCC patients. NSF acts as an oncogenic driver that promotes HCC cell viability and metastasis by physically interacting with cell division cycle 5-like protein (CDC5L) and facilitating its nuclear accumulation in a vesicle-independent manner. In the nucleus, CDC5L transcriptionally activates CDK2-associated cullin 1 (CACUL1) expression via occupation of its promoter element. Thus, our findings provide novel insights into the mechanisms underlying the NSF-induced promotion of HCC progression and suggest potential therapeutic targets in the NSF-CDC5L-CACUL1 axis for HCC therapeutics.
Polyaniline-based 3D Network Structure Promotes Entrapment and Detection of Drug-Resistant Bacteria
Authors: Song Younseong , Park Nahyun , Jo Da Ae , Kim Jueun , Yong Dongeun , Song Jayeon , Park Yoo Min , Lee Seok Jae , Kim Yong Tae , Im Sung Gap , Choi Bong Gill , Kang Tae Joon , Lee Kyoung G. 
Published: March 2023

Abstract
Sensitive and accurate capture, enrichment, and identification of drug-resistant bacteria on human skin are important for early-stage diagnosis and treatment of patients. Herein, we constructed a three-dimensional hierarchically structured polyaniline nanoweb (3D HPN) to capture, enrich, and detect drug-resistant bacteria on-site by rubbing infected skins. These unique hierarchical nanostructures enhance bacteria capture efficiency and help severely deform the surface of the bacteria entrapped on them. Therefore, 3D HPN significantly contributes to the effective and reliable recovery of drug-resistant bacteria from the infected skin and the prevention of potential secondary infection. The recovered bacteria were successfully identified by subsequent real-time polymerase chain reaction (PCR) analysis after the lysis process. The molecular analysis results based on a real-time PCR exhibit excellent sensitivity to detecting target bacteria of concentrations ranging from 102 to 107 CFU/mL without any fluorescent signal interruption. To confirm the field applicability of 3D HPN, it was tested with a drug-resistant model consisting of micropig skin similar to human skin and Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (KPC-CRE). The results show that the detection sensitivity of this assay is 102 CFU/mL. Therefore, 3D HPN can be extended to on-site pathogen detection systems, along with rapid molecular diagnostics through a simple method, to recover KPC-CRE from the skin.
Identifying the Impact of Social Isolation and Loneliness on Psychological Well-being among the Elderly in India: The Mediating Role of Gender, Marital Status, and Education
Authors: Mishra Bijeta , Pradhan Jalandhar , Dhaka Suman 
Published: March 2023

Abstract

Background
Social isolation and loneliness can be detrimental to the overall functioning of the older adults. The study examines the impact of social isolation and loneliness on the psychological well-being of older adults residing in various old-age homes in India and investigates the mediating role of gender, marital status, and education level in the way social isolation and loneliness affect psychological well-being.
Methods
320 individuals aged sixty years or above participated in the study. Data were collected using standardized measures like Lubben Social Network Scale- 6, revised UCLA Loneliness Scale, and shortened version of psychological well-being scale by Ryff & Keyes (1995). Multivariate and mediation analysis were performed to understand the associations of social isolation and loneliness with psychological well-being.
Results
A statistically significant MANOVA effect was obtained for social isolation (F = 3.836, p < .01), and loneliness (F = 3.782, p < .01). Gender and education as independent factors were significantly associated with the psychological well-being of individuals. However, both gender and education did not mediate the impact of social isolation and loneliness on the psychological well-being of older adults. Further, marital status had a partial mediating effect on the relationship between social isolation, loneliness, and psychological well-being.
Conclusions
The findings of the study can be incorporated into measures aiming at alleviation of feelings of social isolation and loneliness among the elderly. Further, the findings can be used to design various intervention strategies aimed at the reduction of social isolation and loneliness among older adults and the restoration of their psychological well-being.
Transformation to a patient-centred medical home led and delivered by an urban Aboriginal and Torres Strait Islander community, and association with engagement and quality-of-care: quantitative findings from a pilot study.
Authors: Mathew Saira , Barzi Federica , Clifford-Motopi Anton , Brown Renee , Ward James , Mills Richard , Lyle Turner , White Antoinette , Eaton Martie , Butler Danielle 
Published: March 2023

Abstract
Background
The patient-centred medical home (PCMH) is a model of primary care that delivers patient-centred care by a team of clinicians that is coordinated, accessible, and focused on quality and safety. In response to substantial population growth and increasing strains on existing primary care services, the Institute for Urban Indigenous Health (IUIH) developed the IUIH System of Care-2 (ISoC2), based on an international Indigenous-led PCMH. ISoC-2 was piloted at an urban Aboriginal and Torres Strait Islander Community-Controlled Health Service in South-East Queensland between 2019–2020, with further adaptations made to ensure its cultural and clinical relevance to local Aboriginal and Torres Strait Islander people. Little is known on the implementation and impact of PCMH in the Australian Indigenous primary care setting. Changes in implementation process measures and outcomes relating to engagement and quality-of-care are described here.
Methods
De-identified routinely collected data extracted from electronic health records for clients regularly attending the service were examined to assess pre-post implementation changes relevant to the study. Process measures included enrolment in PCMH team-based care, and outcome measures included engagement with the health service, continuity-of-care and clinical outcomes.
Results
The number of regular clients within the health service increased from 1,186 pre implementation to 1,606 post implementation; representing a small decrease as a proportion of the services’ catchment population (38.5 to 37.6%). In clients assigned to a care team (60% by end 2020), care was more evenly distributed between providers, with an increased proportion of services provided by the Aboriginal and Torres Strait Islander Health Worker (16–17% versus 10–11%). Post-implementation, 41% of clients had continuity-of-care with the care team, while total, preventive and chronic disease services were comparable pre- and post-implementation. Screening for absolute cardiovascular disease risk improved, although there were no changes in clinical outcomes.
Conclusions
The increase in the number of regular clients assigned to a team and their even distribution of care among care team members provides empirical evidence that the service is transforming to a PCMH. Despite a complex transformation process compounded by the COVID-19 pandemic, levels of service delivery and quality remained relatively stable, with some improvements in risk factor screening.
Prevalence of Fibromyalgia Syndrome in Saudi Arabia: A Systematic Review and Meta- Analysis
Authors: Bawazir Yasser Mohammed 
Published: March 2023

Abstract
Background
The current systematic review and meta-analysis was conducted to estimate the prevalence of fibromyalgia syndrome in Saudi Arabia.
Methods
A PRISMA systematic search appraisal and meta-analysis were conducted. A systematic literature search of English publications in PubMed, Embase, PsycINFO, Web of Science, MEDLINE, and Google Scholar, was conducted up to December 2022. Generic, methodological and statistical data was extracted from the eligible studies. Meta-analysis was done using Comprehensive Meta-Analysis Software. The effect size estimates were calculated using the Fail-Safe N test. The funnel plot, Begg's and Mazumdar's rank correlation tests were employed to find any potential bias. The strength of the association between two variables is assessed using Kendall's tau. A fixed-effects model for the meta-analysis.
Results
The literature search yielded a total of 2479 studies. Eight papers were included in the final analysis with sample size ranging 40 to 1686. All studies were cross-sectional except two, which were retrospective. The total number of the participants recruited in the included articles was 4967 (1794 males and 3173 females); with age ranged between 20 to 79 years. There was high heterogeneity among studies articles (Q = 270.187; p-value 0.001); the tau value was 0.179. The pooled event rates and the 95% confidence intervals (CIs) for the prevalence of fibromyalgia syndrome in Saudi Arabia in a fixed-effects model was 13.4% (95% CI: 0.124–0.144).
Conclusion
Our results clearly demonstrates that fibromyalgia syndrome is highly prevalent (13.4%) in Saudi Arabia. It also more common among women. The high prevalence of fibromyalgia syndrome in Saudi Arabia should be seriously considered and planners should take steps to reduce it.
Comparative transcriptome profiling of high and low grain-iron containing Indian barnyard millet (Echinochloa frumentacea L.) genotypes during different stages of grain development
Authors: Padhiyar Shital M. , Kheni Jasminkumar , Bhatt Shraddha B. , Desai Hiral , Tomar Rukam S. 
Published: March 2023

Abstract
In the era of food nutritional security, the development of minerals-rich grains is an essence for fighting malnutrition. In the present study, we tried to identify the transcripts responsible for the higher accumulation of grain-Fe in Indian barnyard millet through transcriptome sequencing of genotype BAR-1433 (high Fe content) and BAR-1423 (low Fe content) during two stages of spike development i.e., spike emergence and milking stage. During the spike emergence stage, a set of 895 up-regulated and 126 down-regulated transcripts were identified between the high and low grain-Fe containing genotype, while during the milking stage, the number of up-regulated and down-regulated transcripts were 436 and 285. The transcripts which were commonly up-regulated during both the stages were having roles in nucleolar protein, metal-nicotianamine transporter, ribonucleoprotein complex, Vinorine synthase, Cellulose synthase, Auxin response factor, embryogenesis abundant protein, Cytochrome c oxidase, and Zinc finger BED domain-containing protein. Transcripts with significant differences in induction or repression between the two genotypes included genes related to ABC Transporter family proteins, Calcium dependent kinase family, Ferritin, Metal ion binding, Iron-sulfurculster binding, Cytochrome family, Zinc finger transcription factor family, Ferredoxin–NADP reductase type 1 family, Putative laccase, Multicopper oxidase family and Terpene synthase family. Six contigs representing their probable function for metal transporter, iron sulfur, metal ion binding, auxin-responsive GH3-like protein 2, and cytochrome P450 71B16 were used for designing primers to be used for validation. The result of qRT-PCR coincided with the result of the transcriptome. Thus, this study reports a repertoire of genes associated with high iron content in barnyard millet and a proof concept for deployment of transcriptome information for validation in mapping population and its use in marker-assisted selection for bio fortification of barnyard millet with iron. This is first report on a detailed transcriptome analysis to identify transcripts associated with high and low grain-iron content during panicle developmental stages in barnyard millet.
Characteristics of Powder Agar Extracted from Different Seaweeds Species and Locations
Authors: Sinurat Ellya , Fransiska Dina , Utomo Bagus Sediadi Bandol , Subaryono Subaryono , Nurhayati Nurhayati 
Published: March 2023

Abstract

In Indonesia, there are several production centers of agar-producing seaweeds. Research on agar quality has been frequently conducted everywhere, but agar quality test from several locations has never been done simultaneously. The objective of this experiment is to study the quality and characteristics of powder agar extracted from seaweeds harvested from different species and locations in Indonesia i.e., Gracilaria sp from Serang (Banten Province), Brebes (Central Java), and Ujung Genteng (West Java), as well as Gelidium sp from Ujung Genteng (West Java) and Gunung Kidul (Yogyakarta). Agar quality parameters were analyzed based on sensory (score and hedonic test), chemical (moisture, ash, acid insoluble ash, and sulphate content) and physical (viscosity, gel strength and color) parameters; microbiological (TPC, E.coli, moulds and fungi) and heavy metals (Hg, Pb, Cd, and As) contamination. The environmental condition of seaweed growing habitat was also observed, including Dissolved Oxygen (DO), transparency, pH, temperature, salinity, and nutrient content (nitrate, phosphate, ammonia, nitrite, and sulphite). Sensory analysis of powder agars showed that the highest score was achieved by agar extracted from Gracilaria from Ujung Genteng (8.71), and the highest yield was from Gracilaria from Brebes (10.41%). Viscosity and gel strength of agar extracted from Gelidium were higher than that from Gracilaria. The colour of powder agar was closely related to the salinity and water transparency of the seaweed growing habitat. It was concluded that seaweed species and locations affected agar characteristics and quality.
WITHDRAWN: Physical and Mathematical Consistency of the Janus Cosmological Model
Authors: ZEJLI Hasnae , ZEJLI Hicham , PETIT Jean-Pierre , D’Agostini Gilles 
Published: March 2023

Abstract

The Janus Cosmological Model is based on a system of two coupled field equations. It explains the nature of dark matter and dark energy with negative mass and without the runaway paradox that arises in general relativity. We first recall how this system was built, from a simple Newtonian toy model to a relativistic bimetric theory, that is now improved in order to fulfill mathematical constraints and set up on a Lagrangian derivation.
GPU based High-efficiency PSO Algorithm with Initialization strategy and Thread Slef-adaption
Authors: Liu Ye , Wu Jia , Ren Hui , Yang Shuopeng , Zhang Fuqiang , Cao Jie 
Published: March 2023

Abstract
Particle Swarm Optimization (PSO) is one of the most commonly heuristics-based methods that has been used to solve various optimization problems due to its simplicity and robustness. However, when comes to practical applications, it requires a huge computational cost. With the development of parallel computing and Graphics Processing Unit (GPU) calculating, many researchers have tried taking these techniques to break down the obstacle of computational efficiency. It is a challenging problem for the long-term application of PSO. In this paper, we propose a HEPSO algorithm that focuses on the procedure optimization of PSO in GPU-based architecture. It optimizes the GPU computation process from two following aspects: 1) Migrate the data initialization procedure from CPUs to GPUs to reduce the huge IO loss caused by repeating migration while the computing process. 2) Employ a self-adaptive thread management strategy to improve the algorithm execution efficiency. Moreover, we use four benchmark optimization functions to test the efficiency of our HEPSO. The experiment results show that the time speedup ratio between HEPSO and GPU-PSO can exceed 6 times. Meanwhile, when we evaluate the performance of HEPSO with the time consumption for functions converge, HEPSO only needs 1/3 time of GPU-PSO in most cases.
Immune profiling, microbiome, metabolomics, and gut physiology of a 1-year controlled human hookworm infection
Authors: Vacca Francesco , Lavender Brittany , Noble Sophia-Louise , Cait Alissa , Maclean Kate , Mamum John , Yumnam Bibek , Kawa Tama Te , Mules Thomas , Ferrer-Font Laura , Tang Jeffry , Gasser Olivier , Gros Graham Le , Camberis Mali , Inns Stephen 
Published: March 2023

Abstract
The observation that experimental helminth infection can be associated with immunomodulation and suppression of inflammatory diseases at distal tissue sites, has been used as rationale for trialing helminths such as Necator americanus for the treatment of inflammatory disorders in humans. However, the lack of sufficient knowledge of the immunological interplay between human host and parasite in a controlled infection setting limits ongoing clinical intervention studies. In this one-year longitudinal study, healthy volunteers were recruited and infected with N. americanus. Changes in immune responses, microbiome, plasma metabolome and gut physiology were examined over the course of the one-year period. All participants were successfully infected as confirmed by detectable eggs in the feces and adult worms visualized in the intestine. In general, individual variation in immune cells, serum cytokines, fecal microbiome and plasma metabolites were greater than changes induced by the infection. Nevertheless, eosinophils, serum IL-5, and fecal eosinophil degranulation markers transiently increased in the acute phase of infection. In addition, while we observed stability in microbial community composition through the course of infection, we found a difference in the microbial community composition of participants with moderate gastrointestinal symptoms. No significant changes were observed in gut physiology measured using SmartpillTM, except for a decrease in small bowel pH. Untargeted plasma metabolomics analysis of participant plasma over the course of infection revealed enrichment in tryptophan metabolism following infection which was associated with increased CTLA-4 expression on regulatory T cells (TREGS), CRTH2+ T helper 2 cells (TH2) and CCR6+ T helper 9 cells (TH9). In conclusion, hookworm infection is well tolerated and represents an innovative platform for investigating immunomodulatory properties of hookworm infection in a therapeutic clinical setting.
Efficacy and safety of Sanzi-huangshi pill as an adjuvant therapy in lower-risk myelodysplastic syndrome: study protocol for a multi- center randomized controlled trial
Authors: Xu Hao , Hu Qi , Tao Yuchen , Cai Shuyang , Wang Yanlu , Hu Kexin , Xue Tingting , Bao Jizhang , Lu Jiahui 
Published: March 2023

Abstract
Background: Lower-risk myelodysplastic syndrome (MDS) is characterized by the presence of dysplasia, low bone marrow blast percentage, low number and depth of cytopenia(s), and relatively good-risk karyotpic and molecular abnormalities. Lower-risk MDS patients have primarily received supportive care, immunomodulators, and immunosuppressants. New effective regimens or drugs are urgently needed for treatment of lower-risk MDS due to the unsatisfactory clinical efficacy. Sanzi-huangshi pill is an arsenic-containing Chinese medicine as a promising drug used for MDS for decades whose efficacy is not yet proven by high-quality clinical trial.
Methods: SPIRIT guidelines were followed in drafting this protocol for a randomized controlled multicenter trial. Ninety-two adults with lower-risk MDS are randomly assigned in a 1:1 ratio to Sanzi-huangshi pill group or control group, and all participants are required to receive 6 months of intervention and 18 months of observation. The primary outcome is Overall Response Rate defined as the sum of complete remission, partial remission, cytogenetic complete remission and hematologic improvement accounting for the proportion of total evaluable cases.
Discussion: This is the first randomized controlled trial to evaluate the efficacy and safety of arsenic-containing Chinese medicine as an adjuvant therapy in lower-risk MDS with serum erythropoietin (sEPO) >500 IU/ml. The purpose of this study is to correctly evaluate the position of traditional Chinese medicine in the treatment plan of MDS and to formulate an effective regimen of integrated Traditional Chinese and Western Medicine to provide preliminary clinical evidence.
Clinical Trial Registration: http://www.chictr.org.cn, identifier: ChiCTR2200064230, Registered September 30, 2022.
Defect Inspection in Semiconductor Images Using FAST-MCD Method and Neural Network
Authors: Yu Jinkyu , Han Songhee , Lee Chang-Ock 
Published: March 2023

Abstract
Most defect inspection methods used in semiconductor manufacturing require design layout or golden die images.Unlike methods that require such additional information, this paper presents a method for automatic inspection of defects in semiconductor images with a single image.First, we devise a method to classify images into four types: flat, linear, patterned, and complex using a cosine similarity.For linear and patterned images, we obtain defect-free images that retain the structure.Then, subtract defect-free image from input image to get a flat image.The FAST-MCD method then estimates the parameters of the inlier distribution of the flat image and uses them to detect defects.A segmentation neural network is used to detect defects in complex images.