bluuebunny/crossref_metadata_2025_split huggingface dataset:
Falls and fear of falling: an underestimated sequelae in Behçet’s disease
Authors: Kamal Doaa E. , Hassan Rofaida A. , AbdAllah Amany M. , Mostafa Dalia I. 
Published: September 2023

Abstract
Background
Behçet’s disease (BD) is an inflammatory autoimmune disorder. Balance is a multifactorial process that is ultimately affected in BD leading to frequent falls. Fear of falling (FOF) is a significant risk factor for falls. The study aimed to evaluate the risk of falls and FOF in BD and their relations to disease activity and damage.

Results
In BD patients, the history of falls and FOF was 65.6% and 48.4%, respectively. The Berg Balance Scale was low in BD patients (P = 0.003). Falls and fear of falling showed significant relations with the disease activity and disease damage (P < 0.001). There were significant relations between fallers with arthritis (P = 0.003) and active neurological affection (P = 0.004) than non-fallers. A higher balance scale significantly independently decreases the risk of falls (AOR = 0.79, P = 0.005) and FOF (AOR = 0.904, P = 0.039); however, high BD damage and disease duration increase the risk with AOR = 2.364, P = 0.009 and AOR = 0.769, P = 0.088, respectively.

Conclusion
Arthritis and active neurological affection are significantly related to falls and FOF; also, FOF is significantly related to active uveitis. Impaired balance, long disease duration, and high disease damage score are significant risk factors for falls and FOF in BD.
Quality of life and its relation to pediatric asthma severity
Authors: Ali Heba A. 
Published: September 2023

Abstract
Background
Bronchial asthma is a global health problem that negatively affects the quality of life (QOL) of both children and their caregivers. However, there is a paucity of data regarding the impact of QOL on asthma severity in the pediatric population. Therefore, we aimed to examine the effect of health-related QOL of children with asthma and their caregivers on the level of asthma control and the degree of asthma severity.

Results
At enrollment, thirty asthmatic children and their caregivers completed the study. The standardized Arabic versions of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) and the Pediatric Asthma Caregiver’s Quality of Life Questionnaire (PACQLQ) were fulfilled by the asthmatic patients and their caregivers, respectively. Asthma control and severity were assessed using Global Initiative for Asthma guidelines and asthma severity scores. The relations between QOL and the other study parameters including asthma severity were examined which revealed that poor QOL of both asthmatic children and their caregivers was associated with frequent asthma-related hospital admissions (p = 0.046, 0.011). In addition, significant associations were found between symptoms, activity domains of PAQLQ score, and asthma control test score (p = 0.019,0.039). Furthermore, both QOL questionnaires’ total scores correlated strongly with asthma severity scores (p < 0.05 for all).

Conclusions
In this study, QOL appears to be strongly related to the level of asthma control and asthma severity in children. Therefore, improving QOL is recommended for proper management of patients with severe asthma. Moreover, QOL questionnaires can be used as useful tools for monitoring asthma severity in children.
Preparation of anti-canine interleukin-31 receptor alpha polyclonal antibody and evaluation of its therapeutic effect in canine atopic dermatitis
Authors: Li Qiuhua , Qu Yanyan , Yao Li , Ma Ning , Ding Mingxing , Ding Yi 
Published: September 2023

AbstractCanine atopic dermatitis (CAD) is a prevalent genetically susceptible inflammatory and pruritic allergic skin condition affecting not only the health of dogs but also the quality of life of their owners. Interleukin-31 (IL-31) and interleukin-31 receptor alpha (IL-31RA) are essential for the development of pruritus in primates and mice. Hence, it is expected that inhibiting IL-31RA will be an effective approach to alleviate pruritus. The purpose of the study was to produce anti-canine IL-31RA polyclonal antibodies (anti-IL-31RA pAbs) and evaluate their efficacy in inhibiting house dust mite (HDM)-evoked pruritic responses. Dogs were immunized with antigens formed by IL-31RA recombinant short peptides coupled to BSA to produce anti-IL-31RA pAbs. The CAD model was developed by using HDM allergen stimulation, and the effects of IL-31RA pAbs on the reduction of pruritus in CAD model dogs were examined. The Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4 and pruritus Visual Analog Scale (pVAS) were utilized to evaluate pruritic responses, and skin tissue samples were collected from the inguinal area for pathological assessment of skin inflammatory cell infiltration. The results showed that anti-IL-31RA pAbs with high titers (1:128,000) and specificity were effectively produced. In the CAD model group, the severity of skin damage, pruritus score, inflammatory cell infiltration and level of inflammatory factors were considerably elevated. Anti-IL-31RA pAbs relieved pruritic behavior and dermatitis in dogs compared to placebo-treated dogs. In conclusion, anti-IL-31RA pAbs effectively suppressed CAD in vivo and are anticipated to be an effective novel treatment for pruritic skin disorders such as CAD.
Barriers and facilitators to patient-to-provider messaging using the COM-B model and theoretical domains framework: a rapid umbrella review
Authors: MacPherson Megan M. , Kapadia Shabana 
Published: September 2023

Abstract
Background
Virtual patient-to-provider messaging systems such as text messaging have the potential to improve healthcare access; however, little research has used theory to understand the barriers and facilitators impacting uptake of these systems by patients and healthcare providers. This review uses the Capability-Opportunity-Motivation-Behaviour (COM-B) model and the Theoretical Domains Framework (TDF) to explore barriers and facilitators of patient-to-provider messaging.

Methods
A rapid umbrella review method was followed. Medline and CINAHL were searched for review articles that examined patient-to-provider implementation barriers and facilitators by patients or healthcare providers. Two coders extracted implementation barriers and facilitators, and one coder mapped these barriers and facilitators on to the COM-B and TDF.

Results
Fifty-nine unique barriers and facilitators were extracted. Regarding healthcare provider oriented barriers and facilitators, the most frequently identified COM-B components included Reflective Motivation (identified in 42% of provider barriers and facilitators), Psychological Capability (19%) and Physical Opportunity (19%) and TDF domains included Beliefs about Consequences (identified in 28% of provider barriers and facilitators), Environmental Context and Resources (19%), and Social Influences (17%). Regarding patient oriented barriers and facilitators, the most frequently identified COM-B components included Reflective Motivation (identified in 55% of patient barriers and facilitators), Psychological Capability (16%), and Physical Opportunity (16%) and TDF domains included Beliefs about Consequences (identified in 30% of patient barriers and facilitators), Environmental Context and Resources (16%), and Beliefs about Capabilities (11%).

Conclusions
Both patients and healthcare providers experience barriers to implementing patient-to-provider messaging systems. By conducting a COM-B and TDF-based analysis of the implementation barriers and facilitators, this review highlights several theoretical domains for researchers, healthcare systems, and policy-makers to focus on when designing interventions that can effectively target these issues and enhance the impact and reach of virtual messaging systems in the future.
Attempted Suicide: Its Social Significance and Effects by Erwin Stengel and Nancy Cook, with Irving Kreeger
Authors: Millard Chris 
Published: September 2023

SUMMARYStengel, Cook and Kreeger's Attempted Suicide is the most sustained early attempt to draw out the social setting of an attempt at suicide. It is part of a real flourishing of social psychiatry in the UK and reinforces a productive model for collaboration between research psychiatrists and psychiatric social workers in the 1950s and 1960s. The sheer amount of work required for a robust social setting, charting the social repercussions for an attempt at suicide, is laid bare in this text.
Clozapine and Sweet's syndrome: case report
Authors: Bunting Apphia , Silman Daniel , Karia Minesh , Johnson Sophie 
Published: September 2023

A patient developed fever, raised inflammatory markers and a maculopapular rash following commencement of clozapine for treatment of his schizoaffective disorder. Skin biopsy confirmed Sweet's syndrome. Identification of the cause was challenging, with a number of possible considerations including infection, malignancy and various potential drug triggers.
This case highlights the difficulties in the diagnosis of Sweet's syndrome, as well as in identifying the original trigger, which can have significant consequences for management. Withdrawal of potentially causative drugs must be balanced with their benefits, and decisions must be made in the best interests of the patient. Following two courses of prednisolone and withdrawal of clozapine, the patient's rash and systemic symptoms resolved. This confirmed the diagnosis of drug-induced Sweet's syndrome, with clozapine as the offending agent. His mental state stabilised on an alternative antipsychotic.
Perturbative aspects of mass dimension one fermions non-minimally coupled to electromagnetic field
Authors: Carvalho Willian , Dias M. , Lehum A. C. , Hoff da Silva J. M. 
Published: September 2023

Abstract
This paper addresses perturbative aspects of the renormalization of a fermion with mass dimension one non-minimally coupled to the electromagnetic field. Specifically, we calculate the one-loop corrections to the propagators and vertex functions of the model and determine the one-loop beta function of the non-minimal electromagnetic coupling. Additionally, we perform calculations of the two-loop corrections to the gauge field propagator, demonstrating that it remains massless and transverse up to this order. We also find that the non-minimal electromagnetic coupling can exhibit asymptotic freedom if a certain condition is satisfied. As a potential dark matter candidate, these findings suggest that the field may decouple at high energies. This aspect holds significance for calculating the relic abundance and freeze-out temperature of the field, particularly in relation to processes involving the ordinary particles of the Standard Model.
Clinically Driven Alpha/Beta Ratios for Melanoma Brain Metastases and Investigation of Biologically Effective Dose as a Predictor for Local Control After Radiosurgery: A Proof of Concept in a Retrospective Longitudinal Series of 274 Consecutive Lesions
Authors: Zubatkina Irina , Toma-Dasu Iuliana , Dasu Alexandru , Levivier Marc , Tuleasca Constantin , Ivanov Pavel 
Published: September 2023

BACKGROUND AND OBJECTIVES:
Brain metastases (BM) develop in nearly half of the patients with advanced melanoma. The aim of this retrospective historical cohort study was to analyze radiological response of melanoma BM to single-fraction Gamma Knife radiosurgery (GKRS), in relation to biologically effective dose (BED) for various alpha/beta ratios.

METHODS:
Included in the study were 274 lesions. Primary outcome was local control (LC). Mean marginal dose was 21.6 Gy (median 22, range 15-25). Biologically effective dose was calculated for an alpha/beta ratio of 3 (Gy3), 5 (Gy10), 10 (Gy10), and 15 (Gy15).

RESULTS:
Receiver operating characteristic value for LC and BED was 85% (most statistically significant odds ratio 1.14 for BED Gy15, P = .006), while for LC and physical dose was 79% (P = .02). When comparing equality of 2 receiver operating characteristic areas, this was statistically significant (P = .02 and .03). Fractional polynomial regression revealed BED (Gy10 and Gy15) as statistically significant (P = .05) with BED of more than 63 Gy10 or 49 Gy15 as relevant, also for higher probability of quick decrease in volume first month after GKRS and lower probability of radiation necrosis. Shorter irradiation time was associated with better LC (P = .001), particularly less than 40 minutes (LC below 90%, P = .05).

CONCLUSION:
BED Gy10 and particularly Gy15 were more statistically significant than physical dose for LC after GKRS for radioresistant melanoma BM. Irradiation time (per lesion) longer than 40 minutes was predictive for lower rates of LC. Such results need to be validated in larger cohorts.
Early Treatment of Ruptured Cerebral Arteriovenous Malformations: Analysis of Neurological Outcomes and Health Care Costs
Authors: Baranoski Jacob F. , Koester Stefan W. , Catapano Joshua S. , Garcia Joseph H. , Pacult Mark A. , Hoglund Brandon K. , Dabrowski Stephen J. , Benner Dimitri , Winkler Ethan A. , Cole Tyler S. , Rutledge Caleb , Srinivasan Visish M. , Graffeo Christopher S. , Ducruet Andrew F. , Albuquerque Felipe C. , Lawton Michael T. 
Published: September 2023

BACKGROUND:
The timing of surgical resection is controversial when managing ruptured arteriovenous malformations (AVMs) and varies considerably among centers.

OBJECTIVE:
To retrospectively analyze clinical outcomes and hospital costs associated with delayed treatment in a ruptured cerebral AVM patient cohort.

METHODS:
Patients undergoing surgical treatment for a ruptured cerebral AVM (January 1, 2015–December 31, 2020) were retrospectively analyzed. Patients who underwent emergent treatment of a ruptured AVM because of acute herniation were excluded, as were those treated >180 days after rupture. Patients were stratified by the timing of surgical intervention relative to AVM rupture into early (postbleed days 1-20) and delayed (postbleed days 21-180) treatment cohorts.

RESULTS:
Eighty-seven patients were identified. The early treatment cohort comprised 75 (86%) patients. The mean (SD) length of time between AVM rupture and surgical resection was 5 (5) days in the early cohort and 73 (60) days in the delayed cohort (P < .001). The cohorts did not differ with respect to patient demographics, AVM size, Spetzler-Martin grade, frequency of preoperative embolization, or severity of clinical presentation (P ≥ .15). Follow-up neurological status was equivalent between the cohorts (P = .65). The associated mean health care costs were higher in the delayed treatment cohort ($241 597 [$99 363]) than in the early treatment cohort ($133 989 [$110 947]) (P = .02). After adjustment for length of stay, each day of delayed treatment increased cost by a mean of $2465 (95% CI = $967–$3964, P = .002).

CONCLUSION:
Early treatment of ruptured AVMs was associated with significantly lower health care costs than delayed treatment, but surgical and neurological outcomes were equivalent.
Covariation between wrist bone morphology and maximal range of motion during ulnar deviation and supination in extant nonhuman primate taxa
Authors: Vanhoof Marie J. M. , Galletta Lorenzo , De Groote Isabelle , Vereecke Evie E. 
Published: September 2023

ABSTRACT
This study investigates the maximal range of motion (ROM) during wrist deviation and forearm rotation for five different primate genera and the possible correlation with the shape of the distal ulna, triquetrum and hamate. A two-block phylogenetic partial least square analysis was performed to test this covariation in a phylogenetic context, using shape coordinates and a matrix of maximal ROM data as input data. The results show that gibbons have the highest ROM for both ulnar deviation and supination, whereas Macaca exhibited the lowest ROM for supination, and Pan had the lowest ROM for ulnar deviation. These results can be attributed to differences in locomotor behaviour, as gibbons need a large wrist mobility in all directions for their highly arboreal lifestyle, whereas Macaca and Pan need a stable wrist during terrestrial locomotion. However, we found no correlation between distal ulna/triquetrum/hamate shape and maximal ROM during ulnar deviation and supination in the different primate taxa. A larger dataset, in combination with behavioural and biomechanical studies, is needed to establish form–function relationships of the primate hand, which will aid the functional interpretation of primate fossil remains.
Propagation-based phase-contrast imaging of the breast: image quality and the effect of X-ray energy and radiation dose
Authors: Gunaseelan Indusaa , Amin Zadeh Alaleh , Arhatari Benedicta , Maksimenko Anton , Hall Christopher , Hausermann Daniel , Kumar Beena , Fox Jane , Quiney Harry , Lockie Darren , Lewis Sarah , Brennan Patrick , Gureyev Timur , Tavakoli Taba Seyedamir 
Published: September 2023

Objectives:
Propagation-based phase-contrast computed tomography (PB-CT) is a new imaging technique that exploits refractive and absorption properties of X-rays to enhance soft tissue contrast and improve image quality. This study compares image quality of PB-CT and absorption-based CT (AB-CT) for breast imaging while exploring X-ray energy and radiation dose.

Methods:
Thirty-nine mastectomy samples were scanned at energy levels of 28-34keV using a flat panel detector at radiation dose levels of 4mGy and 2mGy. Image quality was assessed using signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), spatial resolution (res) and visibility (vis). Statistical analysis was performed to compare PB-CT images against their corresponding AB-CT images scanned at 32keV and 4mGy.

Results:
The PB-CT images at 4mGy, across nearly all energy levels, demonstrated superior image quality than AB-CT images at the same dose. At some energy levels, the 2mGy PB-CT images also showed better image quality in terms of CNR/Res and vis compared to the 4mGy AB-CT images. At both investigated doses, SNR and SNR/res were found to have a statistically significant difference across all energy levels. The difference in vis was statistically significant at some energy levels.

Conclusion:
This study demonstrates superior image quality of PB-CT over AB-CT, with X-ray energy playing a crucial role in determining image quality parameters.

Advances in knowledge:
Our findings reveal that standard dose PB-CT outperforms standard dose AB-CT across all image quality metrics. Additionally, we demonstrate that low dose PB-CT can produce superior images compared to standard dose AB-CT in terms of CNR/Res and vis.
Filtered back projection vs. iterative reconstruction for CBCT: effects on image noise and processing time
Authors: Ramage Amanda , Lopez Gutierrez Bryan , Fischer Kathleen , Sekula Michael , Santaella Gustavo Machado , Scarfe William , Brasil Danieli Moura , de Oliveira-Santos Christiano 
Published: September 2023

Objectives:
To assess the effect of standard filtered back projection (FBP) and iterative reconstruction (IR) methods on CBCT image noise and processing time (PT), acquired with various acquisition parameters with and without metal artefact reduction (MAR).

Methods:
CBCT scans using the Midmark EIOS unit of a human mandible embedded in soft tissue equivalent material with and without the presence of an implant at mandibular first molar region were acquired at various acquisition settings (milliamperages [4mA-14mA], FOV [5 × 5, 6 × 8, 9 × 10 cm], and resolutions [low, standard, high] and reconstructed using standard FBP and IR, and with and without MAR. The processing time was recorded for each reconstruction. ImageJ was used to analyze specific axial images. Radial transaxial fiducial lines were created relative to the implant site. Standard deviations of the gray density values (image noise) were calculated at fixed distances on the fiducial lines on the buccal and lingual aspects at specific axial levels, and mean values for FBP and IR were compared using paired t-tests. Significance was defined as p &lt; 0.05.

Results:
The overall mean for image noise (± SD) for FBP was 198.65 ± 55.58 and 99.84 ± 16.28 for IR. IR significantly decreased image noise compared to FBP at all acquisition parameters (p &lt; 0.05). Noise reduction among different scanning protocols ranged between 29.7% (5 × 5 cm FOV) and 58.1% (5mA). IR increased processing time by an average of 35.1 s.

Conclusions:
IR significantly reduces CBCT image noise compared to standard FBP without substantially increasing processing time.
Applications of artificial intelligence in the analysis of dental panoramic radiographs: an overview of systematic reviews
Authors: Turosz Natalia , Chęcińska Kamila , Chęciński Maciej , Brzozowska Anita , Nowak Zuzanna , Sikora Maciej 
Published: September 2023

Objectives:
This overview of systematic reviews aimed to establish the current state of knowledge on the suitability of artificial intelligence (AI) in dental panoramic radiograph analysis and illustrate its changes over time.

Methods:
Medical databases covered by the Association for Computing Machinery, Bielefeld Academic Search Engine, Google Scholar, and PubMed engines were searched. The risk of bias was assessed using ROBIS tool. Ultimately, 12 articles were qualified for the qualitative synthesis. The results were visualized with timelines, tables, and charts.

Results:
In the years 1988–2023, a significant development of information technologies for the analysis of DPRs was observed. The latest analyzed AI models achieve high accuracy in detecting caries (91.5%), osteoporosis (89.29%), maxillary sinusitis (87.5%), periodontal bone loss (93.09%), and teeth identification and numbering (93.67%). The detection of periapical lesions is also characterized by high sensitivity (99.95%) and specificity (92%). However, due to the small number of heterogeneous source studies synthesized in systematic reviews, the results of this overview should be interpreted with caution.

Conclusion:
Currently, AI applications can significantly support dentists in dental panoramic radiograph analysis. As systematic reviews on AI become outdated quickly, their regular updating is recommended. PROSPERO registration number: CRD42023416048.