bluuebunny/crossref_metadata_2025_split huggingface dataset:
New insights on Middle and Upper Eocene paleogeography in central and southeastern Tunisia (Gulf of Gabes)
Authors: Njahi-Derbali Zahra , Kassebi Nadhem , Touir Jamel 
Published: June 2023

Abstract
The present work is a contribution to the study of the Middle and Upper Eocene series in the Gulf of Gabes. It aims to study the spatio-temporal variation of the lithofacies in 26 wells. This work is based on the review of the logging data of these wells. A lithostratigraphic correlation and a structural one are established in order to control the relationship between spatio-temporal variations of thickness and lithofacies and early NW-SE faults activities and the resulting structural framework. The present work confirms the spatial lithofacies distribution according NW-SE belts as already mentioned in previous works. In addition, this work shows the basic role of the contemporaneous structural framework as testified by the abrupt spatial variation of both thickness and lithofacies. The sedimentary substratum was cut into piano-key like structure with open marine shallow-water lithofacies on the uplift structures and deep-water low energy restricted lithofacies within the depression structures. Locally some particular lithofacies occur in relation with the hydrodynamic context of the study area with patch-reef windward position and glauconite and organic matter-rich deposits in leeward position. The vertical variation of lithofacies confirms the role of the early tectonic activities, such as during the deposit of Cherahil A and Cherahil B units, the NW-SE oriented faults were rather active, whereas, during the deposit of the median Siouf/Reineche unit the faults were in quiescence testified by the uniformization of shallow carbonate sedimentation. The Middle and Upper Eocene plat-form consists of an irregular cut plat-form.
Is the Ecosystem Services approach incorporated into road development projects in Brazil?
Authors: Neumann Alexandre Guimarães Bilich , Roig Henrique Llacer 
Published: June 2023

Abstract
The aim of this article is to evaluate how the Ecosystem Services (ES) approach is perceived in the environmental assessment of road projects at the federal level in Brazil. An assessment was conducted with the employees of the Brazilian National Department of Transport Infrastructure (DNIT), which is the largest road developer in the country, and an evaluation was also carried out on the environmental licenses issued by the licensing agencies. To make this research possible, a questionnaire was applied to the employees working in the environmental area of the Department, face-to-face meetings were held to gather perceptions, and 12 environmental licenses issued in favor of the DNIT were evaluated. Thus, with these data it was possible to conclude that the view of ES is influenced by the profile of the employee, and that in the majority there is a tendency to attribute greater importance to services of the regulating and provisioning type, while environmental licenses tend to be more balanced among the ES categories, with a tendency to attribute greater importance to cultural ES, especially when traditional communities are involved in the licensing. Hence, it can be inferred that although not a structured perspective, the ES approach appears to exert some impact on road ventures in Brazil.
Decoding inflammation: GARP, miR-142-3-p, and MALAT1 as novel inflammatory biomarkers of IBD
Authors: Lahimchi Mohammad Reza , Mohammadnia-Afrouzi Mousa , Baharlou Rasoul , Haghmorad Dariush , Abedi Seyed Hassan , Arjmandi Delaram , Yousefi Bahman 
Published: June 2023

Abstract
Purpose: Inflammatory bowel disease (IBD) is a life-threatening disorder of the gastrointestinal tract. For the first time, we studied the role of GARP, a crucial regulator of TGF-β synthesis, in Crohn's disease (CD) and ulcerative colitis (UC) patients. We also investigated the upstream regulatory Non-coding RNAs of GARP, namely Lnc-MALAT1 and miR-142-3p. This research sheds light on the mechanisms underlying the development of inflammation in IBD.Methods: A peripheral blood sample was collected from 22 patients with CD, 22 patients with UC, and 22 healthy individuals. PBMCs were isolated, and RNAs were extracted and synthesized into cDNAs. Genes expression was evaluated using the Real-Time PCR method.Results: Our study revealed a decrease in GARP expression in both CD and IBD groups. We also found that the expression of MALAT1 and miR-142-3-p were elevated in CD and IBD groups, contributing to the observed decrease in GARP levels. It also has been discovered that smoking is associated with an increase in MALAT1 expression in all patients.Conclusion: Our research indicates that changes in GARP, MALAT1, and miR-142-3-p levels may be the culprit behind the reduction in TGF-β levels. Moreover, an increase in MALAT1 and miR-142-3-p expression could be responsible for a decrease in GARP levels. These novel biomarkers provide a deeper understanding of the pathways involved in the pathogenesis of IBD and may pave the way for the development of innovative diagnostic or therapeutic approaches.
Ceftriaxone has a neuroprotective effect in a whole brain irradiation-induced neurotoxicity model by increasing GLT-1 and reducing oxidative stress
Authors: ÇİNİ Nilsu , ATASOY Özüm Büke , Uyanıkgil Yiğit , YAPRAK Gökhan , Erbaş Oytun 
Published: June 2023

Abstract
Background: Radiation-induced brain injury is an evident side effect of brain irradiation (IR). Often leads to severe and debilitating cognitive dysfunction and neuronal damage. Ionizing radiation results in oxidative and inflammatory processes. Radiation-induced cognitive impairments are also associated with alterations in glutamate composition. Increased release or decreased uptake of glutamate results in dysregulation of neuronal homeostasis, leading to oxidative stress, mitochondrial dysfunctions, and neuroinflammation.
Materials and Methods: Twenty-one rats were taken in the study, and 14 of underwent whole brain IR with a 20 Gray single dose. Ceftriaxone (CTX) treatment was applied in addition to the IR, for 15 days. Animals were divided into three groups. Group1:Normal control; Group2:Placebo(IR-only), Group3:IR+CTX. The one-way ANOVA statistical test was used to compare groups. The value of p<0.05 was accepted as statistically significant.
Results: In addition to the IR applied CTX treatment exhibited a positive impact on the results of the three-chamber sociability test, open field test and passive avoidance learning test, hippocampal CA1, CA3, and Purkinje neuron counts, brain levels of brain-derived neurotrophic factor, Glutamate transporter-1 and Superoxide dismutases activity. As well, CTX decreased the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde and tumor necrosis factor-alpha.
Conclusion: Ceftriaxone represented a promising effectiveness on radiation-induced neurocognitive impairments and degradation of social-memory capacity by reducing neuronal loss, oxidative stress, and neuroinflammation in the brain. Also, CTX application induces scavenging of glutamate from the synapses helps to prevent glutamate excitotoxicity, and protects neurons from excitotoxic cell death.
Conservation of Native Tree Species in The Agroforest of Rice-Based Agroecosystems Will Contribute to The Sustainable Agriculture
Authors: Lopus Merlin , Jaiswal Deepak , Shakeela V , Reshma D , Shafi Subaiba , Habeeb Abdulla , Kushwaha Amit 
Published: June 2023

Abstract

Traditional agriculture relies on ecosystem services for sustainable food production and is also identified as a climate-smart approach. The present study analyses the agroforests associated with the rice farming system of three different agricultural practices for biodiversity richness by comparing two parameters: plants and birds. Out of the 9 study sites, 3 sites were traditional farms maintained by Kurichiya tribal communities, 3 were natural farms, and the other 3 farms were modern. A total of 45 families, 104 genera, 128 species of plants, and 101 bird species belonged to 48 families, and 17 orders were identified from the study sites. The sample-size-based rarefaction and extrapolation (R/E) method was adopted to identify estimated biodiversity indices. Renyi profile was used to understand the native tree diversity profile of the selected sites. The result of this study indicates that bird diversity is positively correlated with native tree diversity and NDVI of May and October. Conserving more native trees in the farmland could be one of the reasons for the sustainable agriculture system of the Kurichiya tribal community as it attracts more bird species and contributes to the biological control of pests. Thus, the conservation of native tree species in the agroforest of rice-based agroecosystems will contribute to the sustainable agriculture system.
Analogue of Ramanujan's function k(τ) for the continued fraction of order six
Authors: Guadalupe Russelle , Aricheta Victor Manuel 
Published: June 2023

Abstract
We study the modularity of the function $w(\tau) := X(\tau)X(3\tau)$, where $X(\tau)$ is the continued fraction of order six introduced by Vasuki et. al (2010). The function $w(\tau)$ is an analogue of Ramanujan's function $k(\tau)=r(\tau)r(2\tau)^2$, where $r(\tau)$ is the Rogers-Ramanujan continued fraction. We prove that $w(\tau)$ is an $\eta$-quotient that generates the field of all modular functions on the congruence subgroup $\Gamma_0(18)$, and express $X(\tau)$ and $X(3\tau)$ in terms of $w(\tau)$. We also show that there is a modular equation for $w(\tau)$ for all positive integers $n$, and provide explicitly the modular equations of level $p$ for primes $p\leq 13$. We finally show that $w(\frac{\tau}{3})$ generates the ray class field $K_{(3)}$ over an imaginary quadratic field $K$ modulo $3$ for some suitable $\tau\in K$.
Modelling and simulation of the contour error evaluation based on spherically-approximated patches for freeform surface
Authors: Fan Wei , Min Kang , Dai Houfu , Su Zhiwei 
Published: June 2023

Abstract

The mathematical modelling of contour error evaluation in Computer Aided Manufacture (CAM) system is critical for high-precision measurement and manufacture of free-form surface. The existing methods of evaluating the contour errorfor free-form surface have been developed based on various models. Nevertheless, there still exist some of the shortcomings when applied practically, including the inaccurate distance model between the measured point cloud (MPC) and ideal surface, numerical search required for the correspondence, possible local optimum of solution, the inapplicability to all the surfaces, the huge point cloud required, and heavy computational load in the registration iteration, and so forth. Toovercome those shortcomings, this work proposes the spherically-approximated patch (SAP) registrationmethod for the contour error evaluation of free-form surface. The significance of registration between MPC and the SAP set is theoretically analyzed. The SAP set for the ideal surface is efficiently generated based on the centroid-midpoint search of parametric triangle subdivision (CMSPTS). And the tactics of efficiently computing the shortest distance from the MPC to the SAP set based on a local spreading search function (LSSF) is provided. Finally, the scheme of evaluating contour error based on the Point-To-SAP (PTSAP) registration is developed. The comparative simulation and experiment demonstrate that the proposed method raises the registration level between MPC and the ideal surface and produces the evaluation result closer to the theoretical one with an acceptable efficiency, and reduces the size of ideal point cloud compared with the existing methods.
Experimental study on the dissipation performance of supersaturated total dissolved gas in microbubble treatment
Authors: Ou Yangming , Li Zhenjun , Li Ran , Feng Jingjie , Faisal Shah 
Published: June 2023

Abstract
The production of total dissolved gas (TDG) supersaturation resulting from dam discharges has been identified as a causative factor for gas bubble disease (GBD) or mass mortality in fish. In this study, the mitigation solution for fish refuge in supersaturated TDG water was explored by using microbubbles generated by aeration to enhance supersaturated TDG dissipation. The effects of various aeration factors (aeration intensity, water depth, and aerator size) on the dissipation processes of supersaturated TDG were quantitatively investigated through a series of tests conducted in a static aeration column. The results indicated that the dissipation rates of supersaturated TDG increased as a power function with the factors of aeration intensity and aerator size and decreased as a power function with increasing water depth. A universal prediction model for the dissipation rate of supersaturated TDG in the aeration system was developed based on the dimensional analysis of the comprehensive elements, and the parameters in the model were determined using experimental data. The outcomes of this study can furnish an important theoretical foundation and scientific guidance for the utilization of aeration as a measure to alleviate the adverse impacts of supersaturated TDG on fish.
The Anti-inflammatory and Anti-arthritis Activity of Garcinia travancorica in a Rat Model: A Proof of Concept with Computational Studies
Authors: kumar Satish , Srivastava Pratima , Mujwar Somdutt , Gupta Sumeet 
Published: June 2023

Background:
Rheumatoid arthritis is a progressive disease of human joints characterized by severe pain, stiffness, and tissue damage at the local site. Bone and cartilaginous tissue damage at the synovial joints is initiated by the production of autoantibody induced by inflammatory signaling through cytokines.

Objective:
This study aimed to evaluate the efficacy of Garcinia travancorica against acute and chronic inflammation in a rat model after designing the ligand library and target identification using computational analysis.

Methods:
Acute inflammation was induced by carrageen, and chronic inflammation was induced by Freund’s complete adjuvant in the plantar surface of the rats. The petroleum ether, ethanolic, and aqueous extracts in three divided doses (75 mg/kg, 150 mg/kg, and 300 mg/kg) were administered orally. Diclofenac sodium (10 mg/kg), prednisolone (5 mg/kg), and methotrexate (0.5 mg/kg) were used as standard. Various parameters were evaluated, and statistical significance between means was analyzed using one-way ANOVA, followed by Dunnett’s multiple range test.

Results:
Docking-based in-silico screening of the ligand library has revealed the potential of Polyanxanthone-C as an anti-rheumatoid agent, which is supposed to deliver its therapeutic effect by synergistic targeting of interleukin-1, interleukin-6, and tumor necrosis factor receptor type-1.

Conclusion:
This plant has the potential to be used in the treatment of arthritis-related disorders.
Calcium Folate for Reducing the Side Effects of Low-dose Methotrexate in
Rheumatoid Arthritis: A Case Report
Authors: Liu Renzhu , Yan Qingzi , Hu Yixiang , Liu Xiang 
Published: June 2023

Introduction:
We reported a patient with rheumatoid arthritis who received chronic
methotrexate (MTX) therapy and experienced several adverse reactions like hemocytopenia and
renal impairment. Under the monitoring of the therapeutic drug concentration, calcium folate and
other measures were used to accelerate methotrexate excretion and eliminate adverse reactions.

Case Presentation:
A 66-year-old man with rheumatoid arthritis received MTX and developed adverse
effects of bone marrow suppression, like pancytopenia. He had a black stool, and he tested
positive for occult blood, which was considered gastrointestinal bleeding. The blood MTX concentration
reached 4.07 μmol/L, and leucovorin was administered to rescue the patient's life. Besides,
hydration and alkaline urine were applied to quickly clear methotrexate inside the body.

Conclusion:
Low-dose MTX has fewer adverse reactions but may cause bone marrow suppression-
related side effects. Blood concentration monitoring can be used to guide the rescue of MTX
poisoning.
Intellectual Property Rights: Protection of Biotechnological
Inventions in India
Authors: Gomase Virendra , Kemkar Kiran , Potnis Vaishali 
Published: June 2023

Abstract:
The current Intellectual Property Rights (IPR) framework supports the commercialization
of seed improvement, monoculture, and the patent protection of novel plant varieties,
microorganisms, and genetically modified animals. As a consequence, our rich biogenetic
diversity is irreversibly dissipating. However, we need to figure out how to create a
methodology for elective choices that will achieve harmony between the official Intellectual
Property (IP) structure and maintainable biodiversity components. The majority of the
biotechnology sector's programmes in India are managed by the Department of Biotechnology.
It is under the Ministry of Science and Technology. Its goals are to provide services
in the fields of study, infrastructure, human resource development, biotechnology popularisation,
industry promotion, and establishment of centres of excellence. Implementation of
practise biosafety regulations for genetically modified organisms, recombinant DNA products,
and programmes is based on biotechnology for the good of society. This creates an information
network for India's bioinformatics mission in the local, national, and worldwide
scientific community.
Recent Patents on Thermal Characteristic Analysis and Modeling of
Machine Tools
Authors: Li Zhaolong , Du Junming 
Published: June 2023

Abstract:
Modern machining machines are becoming more sophisticated and automated, but the
problems of thermal deformation caused by machining have also come to the fore. CNC machine
tools are used in high-speed, high-feed rate machining conditions, so the impact of thermal deformation
factors will lead to a more prominent loss of accuracy. In this context, the design and
manufacture of future CNC machine tools need to take further account of the errors caused by
thermal deformation and the accompanying loss of accuracy. The principle of thermal characterisation
and thermal error modeling of machine tools is to measure and reasonably analyse the machine
tool at different temperature points and make corrections to the analysis data in order to get
a value as close as possible to the real value and improve machining accuracy. Several representative
patents and studies on thermal characterisation and thermal error modeling of machine
tools at home and abroad are reviewed. This study presents a selection and summary of a large
number of recent patents and studies on machine tool thermal characterisation and thermal error
modeling, focusing on the selection of the machine tool thermal error measurement point area,
thermal error modeling methods, spindle thermal displacement compensation, and other aspects,
and discusses the future trends in the mainstream methods for reducing the thermal error of machine
tools. The analysis and modeling of thermal errors in machine tools have an integral influence
on further improvements in machining accuracy and efficiency in the future.
Design of a Multi-epitope Vaccine against Covid-19: An In silico Approach
Authors: Mishra Kaushal Kishor , Mishra Asheesh Kumar , Anand Vandita , Pandey Anjana , Budhwar Savita , Sharma Deepak Chand 
Published: June 2023

Background:
The control of the Covid-19 epidemic depends on designing a novel, effec-tive vaccine against it. Currently, available vaccines cannot provide complete protection against various mutants of Covid-19.

Objective:
The present investigation aimed to design a new multi-epitope vaccine by using in silico tools.

Methods:
In the present study, the spike-glycoprotein was targeted, desirably stimulating both B and T-cell lymphocytes, providing effective and safe responses in the host immune system. The de-sired vaccine has been found to possess 448 amino acids of spike glycoprotein. The prognosticated epitopes included 10 CTL, 4 linear B-cells, and 14 HTL, including the 128 amino acid sequence of 50S ribosomal protein adjuvant joined by GPGPG and AAY linkers on the N terminus of linear B-cell, HTL, and CTL epitopes, and the C-terminal joined with HHHHHH (6HIS) linker, indicating stability for vaccine structure.

Results:
The molecular docking has revealed the protein-protein restricting communication between the immunization construct and the TLR-3-resistant receptor. The vaccine has been developed through selected epitopes, an adjuvant, and an additional epitope. Docking assays with toll-like re-ceptor 3 have been run on a three-dimensional structural model of the vaccine to gauge its immuno-logical potency. Our findings support the hypothesis that our vaccination will activate TLR-mediated downstream immune pathways by aggressively interacting with the innate receptor.

Conclusion:
The results suggest that the proposed chimeric peptide could initiate an efficient and safe immune response against Covid-19. The proposed vaccine has been proven safe in all critical parameters.
Pembangkit Listrik Tenaga Surya (PLTS) Sebagai Solusi Energi Terbarukan Rumah Tangga
Authors: Nurjaman Hendi Bagja , Purnama Trisna 
Published: June 2023

ABSTRACTAlong with the increasing of electrical energy consumption in Indonesia, the production of electrical energy ought to fulfill its needs. One of the solutions is to utilize renewable and clean energy resources such as using solar power plant as a power source. However, Indonesian people who are used to get services electrical energy from PT PLN (Persero) are not easy to change their power source into solar power plant as their main power source. One of the problems is most of Indonesian people have not understood yet the differences and benefits between solar power plant and PLN electrical energy. Therefore, there must be an educational activity to explain the advantages and disadvantages between solar power plant and PLN electrical energy. It includes technical factors and economic factors. Technical factors mean system of PLTS, generated current (Ampere), generated voltage (Volt), and generated power (kWh) / Watt peak (WP). Whereas, economic factors conceive investment cost, and money saving.ABSTRAKSeiring dengan meningkatnya kebutuhan terhadap pemakaian energi listrik di Indonesia, produksi energi listrik di Indonesia seharusnya mampu mengimbangi kebutuhan tersebut. Salah satu solusinya yaitu dengan memanfaatkan sumber energi terbarukan dan ramah lingkungan seperti Pembangkit Listrik Tenaga Surya. Namun, masyarakat Indonesia yang sudah terbiasa menikmati pelayanan pasokan listrik dari PT PLN (Persero) tidak semudah itu untuk beralih ke pemakaian Pembangkit Listrik Tenaga Surya. Salah satu kendalanya yaitu sebagian masyarakat Indonesia belum memahami perbedaan dan manfaat antara pasokan energi listrik PLTS dan pasokan energi listrik PLN saat ini. Oleh karena itu, diperlukan edukasi untuk memberikan pengetahuan mendasar tentang perbandingan keuntungan dan kerugian pasokan energi listrik dari PLTS dengan pasokan energi listrik dari PLN. Adapun yang menjadi fokus utama pembahasan yaitu dari sisi keandalan energi listrik yang dihasilkan. Keandalan tersebut mencakup faktor teknis dan faktor ekonomis. Adapun faktor teknis yaitu sistem PLTS yang digunakan, arus yang dihasilkan, tegangan yang dihasilkan, dan daya yang dihasilkan. Sedangkan, faktor ekonomis mencakup biaya investasi, penghematan yang didapat.