bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solvent effects on the graphite surface targeting the construction of voltammetric sensors with potential applications in pharmaceutical area
Authors: Vilela Thainá M. , Gonçalves Mateus A. , Martins Roberta C. , Bazzana Matheus J. F. , Saczk Adelir A. , Ramalho Teodorico C. , Felix Fabiana S. 
Published: August 2023

AbstractIn this paper the effect of different solvents (ethanol, acetone, dichloromethane and hexane) in the surface treatment of graphite for the construction of voltammetric sensors was evaluated. During voltammetric experiments of the graphite powder‐based sensor treated with ethanol, it was possible to observe a significant increase in current signals for the redox process of the model analyte (acetaminophen), as well as an increase in the area density of this sensor compared to its unmodified electrode. Theoretical studies involving Density Functional Theory (DFT) and Quantum Theory of Atoms in Molecules (QTAIM) showed greater interaction and stability when graphite was treated with ethanol solvent. Moreover, the theoretical calculations indicated that treating the voltammetric sensor with ethanol offers improvements in the electrochemical response of the model analyte mainly due to a higher spin density, and a partially covalent interaction between solvent and graphite surface. Therefore, graphite powder‐based sensors treated with ethanol were used for determination of acetaminophen in pharmaceutical samples and their results were in good agreement with those obtained by using spectrophotometric method recommended by Pharmacopoeia.
Effectiveness of enhanced cognitive behaviour therapy for patients aged 14 to 25: A promising treatment for anorexia nervosa in transition‐age youth
Authors: Dalle Grave Riccardo , Sartirana Massimiliano , Dalle Grave Anna , Calugi Simona 
Published: August 2023

AbstractObjectiveThe study aimed to evaluate the effectiveness of enhanced cognitive behaviour therapy (CBT‐E) on patients with anorexia nervosa (AN) aged 14 to 25 treated in a real‐world setting.MethodOne hundred and fifteen patients with AN (n = 61, age <18 years) were recruited from consecutive referrals to a clinical eating disorder service offering outpatient CBT‐E. Body Mass Index (BMI), BMI centiles, Eating Disorder Examination Questionnaire, Brief Symptom Inventory, and Clinical Impairment Assessment scores were recorded at admission, at the end of treatment, and at 20‐week follow‐up.ResultsThe seventy‐two patients (62.6%) who finished the programme showed considerable weight gain and reduced scores for clinical impairment and eating‐disorder and general psychopathology. Changes remained stable at 20 weeks. A comparison between adolescent and adult patients indicates similar improvements in eating‐disorder psychopathology.ConclusionsThe benchmark data yielded by this study suggest that CBT‐E is a well‐accepted and promising treatment that could be adopted to ensure continuity of care across the transitional age.
Puerarin protects against acetaminophen‐induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway
Authors: Zhou Wanhai , He Heng , Wei Qin , Che Litao , Zhao Xin , Liu Wenwen , Yan Yue , Hu Lianqing , Du Yonghua , Yin Zhongqiong , Shuai Yongkang , Yang Li , Feng Ruizhang 
Published: August 2023

AbstractPuerarin (Pue) is a kind of isoflavone compound extracted from Pueraria lobata, which has significant antioxidant activity. Excessive use of acetaminophen (APAP) can cause oxidative stress in the liver and eventually lead to acute liver injury. The purpose of this study was to investigate the protective effect and the mechanism of puerarin on APAP‐induced liver oxidative damage. In in vitro experiments, puerarin significantly increased the cell activity of HepG2 cells, reduced the ROS accumulation, alleviated the oxidative damage and mitochondrial dysfunction. In in vivo studies, our results showed that puerarin enhanced antioxidant activity and alleviated histopathological damage. Further studies showed that puerarin decreased the expression of Keap1, promoted the nuclear migration of Nrf2, and up‐regulated the expression of GCLC, GCLM, HO‐1 and NQO1. This study demonstrated that puerarin can protect APAP‐induced liver injury via alleviating oxidative stress and mitochondrial dysfunction by affecting the nuclear migration of Nrf2 via inhibiting Keap1.
How storage time affects sensory, chemical, and physical characteristics of flavored olive oil
Authors: Kacalova Tereza , Jarosova Alzbeta 
Published: August 2023

AbstractThe objectives of this study were to evaluate sensory, chemical, and physical characteristics of olive oil prepared by three flavoring methods and analyze changes during storage (0, 3, and 6 months). Favored olive oil was prepared by three flavoring methods (fresh, dried, and essential oil). Selected sensory, chemical, and color parameters were monitored based on international standards. The color was determined by spectrophotometer. The results confirmed that storage time and flavoring method affect sensory characteristics of the oil. Fresh garlic oil had significantly lower (p < .05) fruity smell. The level of pungent taste significantly increased (p < .05) in the dried rosemary oil, rosemary essential oil, and fresh and dried garlic flavored oils. The intensity of rosemary smell in the sample flavored with essential oil significantly decreased (p < .05) during storage. Opposite effect was observed in the sample flavored with dried rosemary, where the smell significantly increased (p < .05) during storage. The intensity of taste significantly increased (p < .05) in samples flavored by dried rosemary during storage. The peroxide value of all flavored oils samples increased (p < .05) during storage compared to unflavored oil where peroxide value did not change. Color indicators L*, a*, and b* show that addition of fresh rosemary causes the greatest change in olive oil color. The color change, especially the turbidity, was not perceived positive by tasters.
Gleason Grade Group 4 prostate biopsy with no cancer seen on final pathology in the magnetic resonance imaging and Prostate Specific Membrane Antigen‐Positron Emission Tomography era
Authors: Mookerji Nikhile , Mittal Rohan , Hui Amaris , Pfanner Tyler , Broomfield Stacey , Dean Luke , Adam Benjamin , Fung Christopher , Tamm Alexander , Kinnaird Adam 
Published: August 2023

IntroductionThe absence of prostate cancer on final surgical pathology after biopsy‐proven prostate cancer is a rare finding.Case presentationCase of pT0 prostate cancer following Gleason Grade Group 4 in 1 out of 12 cores from a transrectal ultrasound‐guided biopsy in a man who underwent both magnetic resonance imaging and 18F‐PSMA‐1007 Positron Emission Tomography prior to radical prostatectomy.ConclusionpT0 prostate cancer is rare. The use of novel imaging modalities may help in the workup of prostate cancer.
Sacrificial biomaterials in 3D fabrication of scaffolds for tissue engineering applications
Authors: Wang Chi , Zhou Yingge 
Published: August 2023

AbstractThree‐dimensional (3D) printing technology has progressed exceedingly in the area of tissue engineering. Despite the tremendous potential of 3D printing, building scaffolds with complex 3D structure, especially with soft materials, still exist as a challenge due to the low mechanical strength of the materials. Recently, sacrificial materials have emerged as a possible solution to address this issue, as they could serve as temporary support or templates to fabricate scaffolds with intricate geometries, porous structures, and interconnected channels without deformation or collapse. Here, we outline the various types of scaffold biomaterials with sacrificial materials, their pros and cons, and mechanisms behind the sacrificial material removal, compare the manufacturing methods such as salt leaching, electrospinning, injection‐molding, bioprinting with advantages and disadvantages, and discuss how sacrificial materials could be applied in tissue‐specific applications to achieve desired structures. We finally conclude with future challenges and potential research directions.
Endocortical Trabecularization in Acromegaly: The Cause for the Paradoxically Increased Vertebral Fracture Risk?
Authors: Heck Ansgar , Godang Kristin , Lekva Tove , Markussen Kjersti Norman , De Vincentis Sara , Ueland Thor , Bollerslev Jens 
Published: August 2023

ABSTRACTGrowth hormone (GH) is nonphysiologically increased in acromegaly, stimulating target tissues directly and indirectly via insulin‐like growth factor type 1 (IGF‐1). Despite GH having anabolic effects on bone growth and renewal, the risk of vertebral fractures is paradoxically increased in acromegaly. We hypothesized that bone tissue compartments were differentially affected by hormonal alterations in active and controlled acromegaly. We aimed to study the effect of sex and gonadal status on long‐term outcome of bone mass and structure to understand the biomechanical competence of bone. We followed 62 patients with newly diagnosed acromegaly longitudinally (median 4.8 years after pituitary surgery) to investigate changes assessed by dual X‐ray absorptiometry (DXA), trabecular bone score (TBS), and hip structure analysis (HSA). At diagnosis, patients had increased bone mineral density (BMD) in most compartments compared with normative data (Z‐scores). Conversely, TBS Z‐score was decreased (Z = −0.64 (SD 1.73), p = 0.028). Following treatment of acromegaly, BMD increased further in compartments containing predominantly trabecular bone, such as the lumbar spine, in eugonadal and male subjects, while compartments with predominantly cortical bone, such as the hip and femoral neck, were unchanged. Total body measurements showed further increase in BMD independent of sex and gonadal status. TBS did not change. HSA revealed a significant decrease in cortical thickness in both sexes independent of gonadal status, whereas the overall size of bone (hip axis length and neck width) did not change over time. In conclusion, patients with acromegaly had increased bone mass and dimensions by DXA. Following normalization of disease activity, BMD increased mainly in compartments rich in trabecular bone, reflecting a closure of the remodeling space. However, HSA revealed a significant decrease in cortical thickness, implying endocortical trabecularization, potentially explaining the increased risk for incident vertebral fractures following treatment. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
The relationship between purpose in life and depression and anxiety: A meta‐analysis
Authors: Boreham Ian D. , Schutte Nicola S. 
Published: August 2023

AbstractPurpose in life consists of having a sense of meaning and purpose regarding one's activities as well as an overall sense that life is meaningful. This study reports a comprehensive assessment of the relationship of purpose in life with depression and anxiety. A meta‐analysis (total n = 66,468, total k = 99) investigated the association of purpose in life with depression and anxiety. Across samples, greater purpose in life was significantly associated with lower levels of depression and anxiety. The mean weighted effect size between purpose in life and depression was r = −0.49, [95% confidence intervals, CIs: −0.52, −0.45], p < 0.001. For the purpose in life and anxiety the mean weighted effect size was r = −0.36, [95% CIs: −0.40, −0.32], p < 0.001. The association of purpose in life with mental health was stronger for clinical populations, especially with regard to the relationship with anxiety. Both approach deficits and avoidance motivation are argued to play a role in the relationship between purpose and psychopathology, with greater purpose potentially limiting avoidance tendencies and reducing the effects of depression and anxiety. Understanding the role that purpose in life may play in depression and anxiety could help to inform current conceptualizations of these disorders and improve treatment outcomes.
Sperm morphology and comparison morphometry measurements of two species of bats,Molossus molossusandMolossops temminckii(Chiroptera: Molossidae)
Authors: Dip Ana Sofía , Martín Eduardo , Andrada Rubén Aldo , Hernández Marcela Beatriz , Miotti María Daniela 
Published: August 2023

AbstractSperm morphology is considered a species‐specific character and has been used as a tool in the classification of numerous mammalian taxa. Neotropical bats have been poorly studied, and important aspects on sperm morphology have not been elucidated. The aim of the present study was to describe and compare the sperm morphology and morphometry ofMolossus molossusandMolossops temminckii. A total of 14 adults specimens were analyzed from the Colección Mamíferos Lillo, Universidad Nacional de Tucumán: fiveM. molossusand nineM. temminckii. The epididymis were extracted and macerated in Farmer's solution, followed by a coloration with different stains. To carry out the description and morphometric analysis, microphotographs were taken under an optical, epifluorescence, and scanning electron microscope (SEM). A total of 50 sperm from each individual were measured for morphometric analysis. The length and width of the head, midpiece and tail were taken as variables. Sperm fromM. molossusandM. temminckiiwere practically identical, both morphologically and morphometrically. In both species, a distal bulge was observed at the end of the intermediate piece in a percentage greater than 85%. The main characteristics shared between the species were: presence of acrosomal blebs in the upper half of the head of the spermatozoa; cephalic equatorial segment with filiform ornamentations; intermembrane space of head apex wedge‐shaped; helical middle piece and annulus at the end of middle piece. In the present study, SEM allowed us to visualize structures, such as acrosomal vesicles, that were not detected with other types of microscopy.Research HighlightsThe similarities in the sperm morphology betweenM. molossusandM. temminckiiwere observed with three types of microscopy: optical, epifluorescence and scanning electron, and supported by morphometric and statistical analyses.
Molecular MR Imaging of Prostate Cancer by Specified Iron Oxide Nanoparticles With PSMA‐11 Peptides: A Preclinical Study
Authors: Ghorbani Farzaneh , Aminzadeh Behzad , Borji Nahid , Soudmand Samaneh , Montazerabadi Alireza 
Published: August 2023

BackgroundProstate‐specific membrane antigen (PSMA) can provide a prostate cancer (PCa) detection approach in positron emission tomography (PET) using Food and Drug Administration (FDA)‐approved PSMA‐11 peptide. There are some studies evaluated magnetic‐nanoprobes for PSMA detection by MRI, using non‐FDA‐approved ligands including antibodies or peptides, which are not as specific as PSMA‐11.PurposeTo assess targeted iron oxide nanoparticles (IONPs) by PSMA‐11 peptides as a potential specific nano‐molecular probes to investigate a PSMA+ PCa‐xenograft model by MRI.Study TypeProspective.Animal ModelTwenty male C57BL6 nude mice induced subcutaneously PSMA+ LNCaP cell line tumor.Field Strength/Sequence1.5 T, T2‐W Fast Spin echo and T2*‐W Gradient echo.AssessmentCoated IONPs with Carboxymethylated‐dextran (DNPs) and with bovine serum albumin (BNPs), as well as, targeted DNPs with PSMA‐11‐HYNIC peptide (TDNPs) and targeted BNPs with PSMA‐11‐HBED peptide (TBNPs) were injected intravenously with dose 2.8 mg Fe/kg. Coronal T2‐W and the T2*‐W images were obtained before and 4 hours and 6 hours post‐injection. Signal intensity (SI) and relative signal enhancement (RSE) were computed in two‐ and three‐dimensional analyses. Histological analysis of tumors was evaluated, and the Fe distribution within the body based on atomic absorption spectroscopy was calculated.Statistical TestsOne‐way ANOVA followed by Tukey's multiple comparison test, Paired‐samples T‐test, P < 0.05 was considered significant.ResultsA reduction in T2‐W SI was achieved as 22 ± 7%, 59 ± 3%, 65 ± 5%, and 78 ± 3% respectively for BNPs, TBNPs, DNPs, and TDNPs 6 hours post‐injection. The most difference between targeted and non‐targeted groups was observed at 6 hours for PSMA‐11‐HBED, and at 4 hours for PSMA‐11‐HYNIC. RSE indicated 88.6 ± 3.1% and 80.7 ± 3.2% enhanced contrast between tumor and muscle region for TBNPs and TDNPs on T2*‐W images.ConclusionsBoth TBNPs and TDNPs are promising novel nano‐molecular probes for PSMA+ PCa tumor detection. The injection dose of non‐targeted IONPs can be reduced by using targeted nanoprobes three times for BNPs and two times for DNPs.Evidence Level1Technical EfficacyStage 1
Federated Learning: A Cross‐Institutional Feasibility Study of Deep Learning Based Intracranial Tumor Delineation Framework for Stereotactic Radiosurgery
Authors: Lee Wei‐Kai , Hong Jia‐Sheng , Lin Yi‐Hui , Lu Yung‐Fa , Hsu Ying‐Yi , Lee Cheng‐Chia , Yang Huai‐Che , Wu Chih‐Chun , Lu Chia‐Feng , Sun Ming‐His , Pan Hung‐Chuan , Wu Hsiu‐Mei , Chung Wen‐Yuh , Guo Wan‐Yuo , You Weir‐Chiang , Wu Yu‐Te 
Published: August 2023

BackgroundDeep learning–based segmentation algorithms usually required large or multi‐institute data sets to improve the performance and ability of generalization. However, protecting patient privacy is a key concern in the multi‐institutional studies when conventional centralized learning (CL) is used.PurposeTo explores the feasibility of a proposed lesion delineation for stereotactic radiosurgery (SRS) scheme for federated learning (FL), which can solve decentralization and privacy protection concerns.Study TypeRetrospective.Subjects506 and 118 vestibular schwannoma patients aged 15–88 and 22–85 from two institutes, respectively; 1069 and 256 meningioma patients aged 12–91 and 23–85, respectively; 574 and 705 brain metastasis patients aged 26–92 and 28–89, respectively.Field Strength/Sequence1.5T, spin‐echo, and gradient‐echo [Correction added after first online publication on 21 August 2023. Field Strength has been changed to “1.5T” from “5T” in this sentence.].AssessmentThe proposed lesion delineation method was integrated into an FL framework, and CL models were established as the baseline. The effect of image standardization strategies was also explored. The dice coefficient was used to evaluate the segmentation between the predicted delineation and the ground truth, which was manual delineated by neurosurgeons and a neuroradiologist.Statistical TestsThe paired t‐test was applied to compare the mean for the evaluated dice scores (p < 0.05).ResultsFL performed the comparable mean dice coefficient to CL for the testing set of Taipei Veterans General Hospital regardless of standardization and parameter; for the Taichung Veterans General Hospital data, CL significantly (p < 0.05) outperformed FL while using bi‐parameter, but comparable results while using single‐parameter. For the non‐SRS data, FL achieved the comparable applicability to CL with mean dice 0.78 versus 0.78 (without standardization), and outperformed to the baseline models of two institutes.Data ConclusionThe proposed lesion delineation successfully implemented into an FL framework. The FL models were applicable on SRS data of each participating institute, and the FL exhibited comparable mean dice coefficient to CL on non‐SRS dataset. Standardization strategies would be recommended when FL is used.Level of Evidence4Technical EfficacyStage 1
On the coupled interdecadal variations of the extra‐tropical surface air temperature and the isentropic meridional airmass transport in Northern winter
Authors: Liu Bowen , Ren Rongcai , Yu Yueyue 
Published: August 2023

AbstractBased on the ERA5 reanalysis since the 1950s, this study investigates the coherent inter‐decadal variations of the winter continental surface air temperature (SAT) between the Eurasian (EUA) and the North American continents in the past 70 years. The SAT variation over the two continents can be characterized with five typical periods successively from a ‘both‐warmer’ (1950s–1960s), to a ‘both‐colder’ (1960s–1980s), and then a ‘EUA‐warmer’ (1980s–1990s) followed by another ‘both‐warmer’ (1990s–2000s) and a ‘EUA‐colder’ (2000s–2010s) period. Such periodic variation of the SAT is closely coupled with changes of the low isentropic‐level meridional mass transport (IMMT), as manifested by the coupling relationship between the midlatitude SAT and the net IMMT out of the polar circle, in terms of their zonal patterns and geographical patterns. The SAT variation can be well reconstructed with the first two leading maximum covariance analysis (MCA) modes between the SAT and IMMT. The first leading MCA mode (MCA1) mainly dominates a ‘EUA‐warmer/colder’ pattern, while the second (MCA2) dominates the ‘both‐warmer/colder’ pattern. There exists a significant lead–lag correlation between the MCA1 and MCA2, which determines the changing SAT pattern in the five successive periods. Furthermore, the MCA1 and MCA2, especially their lead–lag coupling after the 1975 is significantly associated with the Pacific decadal oscillation (PDO) which dominates the much‐intensified MCA1 and the related ‘EUA‐warmer/colder’ SAT pattern since then. The Atlantic multi‐decadal oscillation mainly dominates the third leading MCA mode with it's effects on the SAT over Europe coincidently to amplify the PDO‐related SAT changes.
Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries
Authors: Plachká Kateřina , Pilařová Veronika , Horáček Ondřej , Gazárková Taťána , Vlčková Hana Kočová , Kučera Radim , Nováková Lucie 
Published: August 2023

Within this review, we thoroughly explored supercritical fluid chromatography (SFC) columns used across > 3000 papers published from the first study carried out under SFC conditions in 1962 to the end of 2022. We focused on the open tubular capillary, packed capillary, and packed columns, their chemistries, dimensions, and trends in used stationary phases with correlation to their specific interactions, advantages, drawbacks, used instrumentation, and application field. Since the 1990s, packed columns with liquid chromatography and SFC‐dedicated stationary phases for chiral and achiral separation are predominantly used. These stationary phases are based on silica support modified with a wide range of chemical moieties. Moreover, numerous unconventional stationary phases were evaluated, including porous graphitic carbon, titania, zirconia, alumina, liquid crystals, and ionic liquids. The applications of unconventional stationary phases are described in detail as they bring essential findings required for further development of the supercritical fluid chromatography technique.
A multidimensional journal evaluation framework based on the Pareto‐dominated set measured by the Manhattan distance
Authors: Xu Xinxin , Zeng Ziqiang , Chang Yurui 
Published: August 2023

AbstractJournal evaluation is a multifaceted issue, and multidimensional information cannot be conflated into one metric due to the inability of a single indicator to reflect the quality of a journal. The goal of this paper is to develop a multidimensional journal evaluation framework based on the Pareto‐dominated set through integrating information measured by the Manhattan distance related to article performance, academic communities, and publishing platforms. This paper identifies 29 related indexes to form a three‐dimensional (3D) journal evaluation framework with metrics involving stakeholders in journal publication. To reduce multicollinearity among related indexes, a factor analysis‐based entropy weight method is proposed to integrate the multidimensional information into five aggregated indicators and then transform them into a 3D‐weighted influence factor coordinate system. A journal evaluation framework is defined based on the Pareto‐dominated set of a journal in the 3D‐coordinate system measured by the Manhattan distance to assess journal impact. A case study has been implemented based on 124 journals selected from the “Statistics & Probability” category in the 2019 Journal Citation Report to demonstrate the validity of the proposed method.