bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training for Awake, Office‐Based Laryngeal Procedures—The Laryngology Fellow's Perspective
Authors: Shuman Elizabeth A. , Dwyer Christopher D. 
Published: September 2023

ObjectiveThe aim was to explore recent laryngology graduates' perspectives on their experience, competency, and challenges learning office‐based procedures during fellowship training in the United States and Canada.MethodsAnonymous 22‐item questionnaire survey was distributed electronically to fellowship‐trained laryngologists having completed fellowship within past 5 years.ResultsNinety fellowship‐trained laryngologists between 2018 and 2022 were surveyed. Response rate was 48.9% (n = 44), 1 declined participation, with 20 different fellowship programs represented. Fellows were frequently provided the opportunity to act as primary surgeon for most procedures, except for laryngeal botulinum toxin injection, diagnostic laryngeal electromyography, trans‐nasal esophagoscopy, secondary tracheoesophageal puncture, and high‐resolution pharyngeal manometry. A majority reported high (n = 27, 62.8%) or moderate (n = 12, 27.9%) confidence with vocal fold injection augmentation. Various techniques were taught: transoral (74.4%), cricothyroid (74.4%), thyrohyoid (69.8%), transcartilagenous (14.0%), and catheter‐needle (25.6%). Numerous statistically significant associations with independent procedure involvement and competence were identified. Laryngeal botulinum toxin injection was a procedure performed with high frequency but low volume of independent fellow involvement, and the procedure with which fellows reported wanting more practice learning. Most common training barriers included patient being awake, patient consenting to trainee performing the procedure, and the technical challenge/complexity of the procedure. Teaching methods/tools largely focused on informal debriefing (97.3%) and case by case troubleshooting (81.1%).ConclusionsLaryngology fellows are well trained with favorable perceived levels of competence for numerous office‐based procedures, particularly vocal fold injection augmentation. Procedures for which fellows reported a low level of independent participation trended towards lower perceived competency.Level of Evidence5 Laryngoscope, 134:873–881, 2024
Exploring the urban–rural gradient effects of construction land expansion processes on land use function trade‐off/synergy in rapidly urbanizing areas
Authors: Li Sinan , Zhu Congmou , Deng Xiaodong 
Published: September 2023

AbstractConstruction land expansion greatly affects the supply and interaction of distinct land use functions, particularly in rapidly urbanizing areas. However, existing research rarely focuses on the urban–rural gradient role of different construction land expansion processes in affecting the interactions between land use functions, which limits the refined high‐quality development of territorial space. Using the main urban area of Hangzhou as an example, this research analyzed the spatiotemporal transmission process of trade‐offs/synergies among distinct functions between urban and rural regions from the living‐production‐ecological function perspective, and probed the differences in the impact of distinct urban and rural construction land expansion processes on them across different urban–rural gradients, thereby proposing the urban–rural spatial development pathways for promoting synergistic territorial spatial patterns. The results showed that the changes in different functions had an obvious urban–rural gradient difference. During 2000–2020, the trade‐off between living function and other functions increased continuously, and regions with a higher trade‐off primarily shifted from urban development areas to urban–rural transition areas. The infilling and edge‐expansion of urban construction land were more favorable to the increased synergy between distinct functions; the infilling and edge‐expansion of rural construction land in urban development and urban–rural transition areas greatly reduced the functional trade‐off level, while its leapfrogging in rural development areas strongly affected the synergy between distinct functions. These findings can help to restrict unreasonable urban and rural construction land expansion processes as well as promote synergistic territorial space patterns in rapidly urbanizing regions.
Novel Polycaprolactone‐Chitosan Hybrid Scaffold: A Double‐Sided Hernia Mesh for Regeneration of Abdominal Wall Defects with Minimized Adverse Adhesions
Authors: Asvar Zahra , Fadaie Milad , Azarpira Negar , Mirzaei Esmaeil 
Published: September 2023

AbstractAs an alternative for currently available hernia meshes, electrospun scaffolds represent good biocompatibility and favorable healing performance. However, they usually cannot meet the minimum mechanical requirements for a successful hernia repair. Here, a double‐faced hernia mesh comprised of electrospun polycaprolactone fibers (PCL) and chitosan nanofibers (CS) is developed to address this limitation. The privileged fibrous structure of PCL, in visceral side, can potentially guarantee the required mechanical criteria to withstand intra‐abdominal pressures and minimizing adverse adhesions. On the ventral side (facing incision), a stabilized CS layer is developed to improve cellular behavior and tissue regeneration. According to the results, PCL‐CS scaffold (thickness ≈ 500 µm) properly matches with the mechanical properties of native abdominal wall and closely meets the suggested thresholds in strength (33.3 N cm−1) and elasticity (15.26%). Superior cytocompatibility of PCL‐CS is confirmed by the in vitro studies using L929 fibroblasts and human umbilical vein endothelial cells. Full‐thickness abdominal wall defects are used to compare tissue regeneration and adverse adhesions for PCL‐CS with the polypropylene commercial mesh (Prolene) and suture groups. Gross examinations demonstrate lower rate of unfavorable adhesions in PCL‐CS compared to Prolene and suture groups. Concerning the histological analyses, PCL‐CS exhibits reduced inflammation, less fibrosis, and better tissue remodeling.
Type I Collagen‐Adhesive and ROS‐Scavenging Nanoreactors Enhanced Retinal Ganglion Cell Survival in an Experimental Optic Nerve Crush Model
Authors: Du Yuyuan , Cai Maoyu , Mu Jingqing , Li Xingwei , Song Yapeng , Yuan Xiaoyong , Hua Xia , Guo Shutao 
Published: September 2023

AbstractTraumatic optic neuropathy (TON) is a severe condition characterized by retinal ganglion cell (RGC) death, often leading to irreversible vision loss, and the death of RGCs is closely associated with oxidative stress. Unfortunately, effective treatment options for TON are lacking. To address this, catalase (CAT) is encapsulated in a tannic acid (TA)/poly(ethylenimine)‐crosslinked hollow nanoreactor (CAT@PTP), which exhibited enhanced anchoring in the retina due to TA–collagen adhesion. The antioxidative activity of both CAT and TA synergistically eliminated reactive oxygen species (ROS) to save RGCs in the retina, thereby treating TON. In vitro experiments demonstrated that the nanoreactors preserve the enzymatic activity of CAT and exhibit high adhesion to type I collagen. The combination of CAT and TA‐based nanoreactors enhanced ROS elimination while maintaining high biocompatibility. In an optic nerve crush rat model, CAT@PTP is effectively anchored to the retina via TA–collagen adhesion after a single vitreous injection, and RGCs are significantly preserved without adverse events. CAT@PTP exhibited a protective effect on retinal function. Given the abundance of collagen that exists in ocular tissues, these findings may contribute to the further application of this multifunctional nanoreactor in ocular diseases to improve therapeutic efficacy and reduce adverse effects.
Recent advances of nanobody applications in diagnosis and detection
Authors: Su Qianling , Shi Wei , Huang Xianing , Yin Shihua , Yang Xiaomei , Lu Xiaoling 
Published: September 2023

AbstractNanobodies (Nbs) are the variable domain of heavy‐chain antibodies derived from the blood of camelids or sharks. Nanobodies are the smallest antibody fragment with intact antigen‐binding ability. Compared to conventional antibodies, nanobodies have unique properties such as small size, excellent stability and solubility, low immunogenicity, ability to recognize hidden epitopes, high tissue penetration, and industrialized production. More excitingly, the camelid‐specific amino acid sequences in the framework are mutated to their human heavy‐chain variable domain equivalent, which is humanized, to a wide range of applications. These superior characteristics make nanobody an ideal alternative to conventional antibody, showing excellent prospects for various applications in structural biology, molecular imaging, disease diagnosis and therapy, agricultural products, and environmental chemicals detection. With the continuous updating of theories and the rapid development of technology, the screening and expression methods of nanobodies are increasingly mature. Consequently, several technologies to identify and express nanobodies have been established, and various use cases have been described. In this review, we summarize recent advances in the discovery and production of novel nanobodies, and their use in detection and diagnosis platforms.
Environmental selection and evolutionary process jointly shape genomic and functional profiles of mangrove rhizosphere microbiomes
Authors: Yu Xiaoli , Tu Qichao , Liu Jihua , Peng Yisheng , Wang Cheng , Xiao Fanshu , Lian Yingli , Yang Xueqin , Hu Ruiwen , Yu Huang , Qian Lu , Wu Daoming , He Ziying , Shu Longfei , He Qiang , Tian Yun , Wang Faming , Wang Shanquan , Wu Bo , Huang Zhijian , He Jianguo , Yan Qingyun , He Zhili 
Published: September 2023

AbstractMangrove reforestation with introduced species has been an important strategy to restore mangrove ecosystem functioning. However, how such activities affect microbially driven methane (CH4), nitrogen (N), and sulfur (S) cycling of rhizosphere microbiomes remains unclear. To understand the effect of environmental selection and the evolutionary process on microbially driven biogeochemical cycles in native and introduced mangrove rhizospheres, we analyzed key genomic and functional profiles of rhizosphere microbiomes from native and introduced mangrove species by metagenome sequencing technologies. Compared with the native mangrove (Kandelia obovata, KO), the introduced mangrove (Sonneratia apetala, SA) rhizosphere microbiome had significantly (p < 0.05) higher average genome size (AGS) (5.8 vs. 5.5 Mb), average 16S ribosomal RNA gene copy number (3.5 vs. 3.1), relative abundances of mobile genetic elements, and functional diversity in terms of the Shannon index (7.88 vs. 7.84) but lower functional potentials involved in CH4 cycling (e.g., mcrABCDG and pmoABC), N2 fixation (nifHDK), and inorganic S cycling (dsrAB, dsrC, dsrMKJOP, soxB, sqr, and fccAB). Similar results were also observed from the recovered Proteobacterial metagenome‐assembled genomes with a higher AGS and distinct functions in the introduced mangrove rhizosphere. Additionally, salinity and ammonium were identified as the main environmental drivers of functional profiles of mangrove rhizosphere microbiomes through deterministic processes. This study advances our understanding of microbially mediated biogeochemical cycling of CH4, N, and S in the mangrove rhizosphere and provides novel insights into the influence of environmental selection and evolutionary processes on ecosystem functions, which has important implications for future mangrove reforestation.
Slot‐loading based compact wideband monopole antenna design and isolation improvement of MIMO for Wi‐Fi sensing application
Authors: Hossen Mohammad Rabiul , Ramzan Mehrab , Sen Padmanava 
Published: September 2023

AbstractThe dense establishment of the Wi‐Fi devices creates an opportunity to map the surrounding environment using Wi‐Fi signals as sounding waveforms. Recently, the Channel State Information (CSI) measurement analysis from Wi‐Fi networks has been widely used for detecting and possibly tracking the presence of obstacles between a transmitter and a receiver. According to the IEEE 802.11bf Task Group, Wi‐Fi sensing will utilize a band between 5.925 and 7.125 GHz, making the CSI measurement finer‐grained with the additional large bandwidth. In this paper, a wideband compact antenna is designed targeting the 5.9–7.1 GHz band based on the slot‐loading technique. Later, a wideband multiple‐input multiple‐output (MIMO) antenna is designed using defected ground structures, protruded ground, and electromagnetic band gap structures for isolation improvement, and the measured isolation shows 30–45 dB between the elements in the operating frequency range. The envelope correlation coefficient is less than 0.001 with the diversity gain being nearly 10. The fabricated single antenna has a compactness of 0.3 in both dimensions (14 mm  14 mm), measured bandwidth of 1.55 GHz (5.95–7.5 GHz) with a peak gain of 2.2 dBi at 6.8 GHz, and 90% efficiency in the operating frequency range whereas the wideband MIMO antenna has a size of 14 mm  37 mm with 0.5 spacing between the elements.
Generation and comparison of 3D dosimetric reference datasets for COMS eye plaque brachytherapy using model‐based dose calculations
Authors: Fletcher Elizabeth M. , Ballester Facundo , Beaulieu Luc , Morrison Hali , Poher Audran , Rivard Mark J. , Sloboda Ron S. , Vijande Javier , Thomson Rowan M. 
Published: September 2023

AbstractPurposeA joint Working Group of the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) was created to aid in the transition from the AAPM TG‐43 dose calculation formalism, the current standard, to model‐based dose calculations. This work establishes the first test cases for low‐energy photon‐emitting brachytherapy using model‐based dose calculation algorithms (MBDCAs).Acquisition and Validation MethodsFive test cases are developed: (1) a single model 6711 125I brachytherapy seed in water, 13 seeds (2) individually and (3) in combination in water, (4) the full Collaborative Ocular Melanoma Study (COMS) 16 mm eye plaque in water, and (5) the full plaque in a realistic eye phantom. Calculations are done with four Monte Carlo (MC) codes and a research version of a commercial treatment planning system (TPS). For all test cases, local agreement of MC codes was within ∼2.5% and global agreement was ∼2% (4% for test case 5). MC agreement was within expected uncertainties. Local agreement of TPS with MC was within 5% for test case 1 and ∼20% for test cases 4 and 5, and global agreement was within 0.4% for test case 1 and 10% for test cases 4 and 5.Data Format and Usage NotesDose distributions for each set of MC and TPS calculations are available online (https://doi.org/10.52519/00005) along with input files and all other information necessary to repeat the calculations.Potential ApplicationsThese data can be used to support commissioning of MBDCAs for low‐energy brachytherapy as recommended by TGs 186 and 221 and AAPM Report 372. This work additionally lays out a sample framework for the development of test cases that can be extended to other applications beyond eye plaque brachytherapy.
Midwives' experiences with providing home‐based postpartum care during the COVID‐19 pandemic: A qualitative study
Authors: Akselsen Hanne Marie , Leknes Emilie Hanssen , Engen Tone , Vik Eline Skirnisdottir , Nilsen Anne Britt Vika 
Published: September 2023

AbstractAimTo explore midwives' experiences with providing home‐based postpartum care during the COVID‐19 pandemic in Norway.DesignA descriptive and explorative qualitative study.MethodsThe study is based on semi‐structured individual interviews with 11 midwives experienced in offering home‐based postpartum care. We explored their experiences of such care during the first wave of the COVID‐19 pandemic. Data collection occurred from October through November 2020. An inductive thematic analysis was performed using Systematic Text Condensation (STC) by Malterud (2012).ResultsThe following two main results emerged from the analyses: (1) the midwives adapted quickly to changes in postpartum care during the pandemic and (2) midwives saw the experience as an opportunity to re‐evaluate their practices.ConclusionThis study highlights midwives' resilience and adaptability during the first wave of COVID‐19 pandemic. It emphasises the crucial role of face‐to‐face interactions in postpartum care, while recognising the value of technology when direct access is limited. By shedding light on midwives' experiences, this research contributes to improving postpartum care in unforeseen circumstances. It underscores the significance of interdisciplinary integration in planning postpartum care services and the lasting influence of lessons learned on addressing future challenges.Implications for PracticeThe valuable insights gained from lessons learned during the COVID‐19 pandemic may have a lasting influence on the postpartum care system, empowering it to tackle unforeseen challenges both today and in the future.ImpactThe current study addressed midwives' experience with providing home‐based postpartum care during the COVID‐19 pandemic in Norway. Midwives received an opportunity to re‐evaluate their own practices and valued being included when changes were implemented. The current findings should alert policy makers, leaders and clinicians in postpartum care services when planning future practice.
Impact of European Union label changes to avoid inadvertent use of medicinal products containing methotrexate for once‐weekly administration: A survey amongst prescribers, pharmacists and patients on awareness, knowledge, and behaviour
Authors: Lysen Thom , Karimi Leila , Wang Mo , Singh Shubhra , Toussi Massoud 
Published: September 2023

AbstractPurposeTo determine the effectiveness of risk minimisation measures (RMM) to avoid inadvertent daily instead of weekly methotrexate (MTX) use, introduced by the European Medicines Agency (EMA) from 2019 onwards.MethodsUsing a cross‐sectional online survey in France, Greece, Germany, Poland, and Sweden in 2022, we assessed awareness, knowledge, and self‐declared behaviour for respondents who prescribed, dispensed, or used once‐weekly MTX in the last 3 months. Respondents' answers were considered as ‘successful’ with regards to RMM effectiveness (vs. unsuccessful) if they provided correct (‘desirable’) responses to 100% of questions regarding awareness and self‐declared behaviour and correct responses to ≥80% of questions about knowledge. Per target population, an outcome was considered successful if achieved by ≥80% of respondents. Effectiveness of RMM was defined by ≥80% being successful on all outcomes.ResultsOne‐hundred‐fifty‐one prescribers, 150 pharmacists, and 150 patients completed the survey. Success rates were 56% (95% CI 48.0%–64.3%) for awareness, 42% (95% CI 34.4%–50.7%) for knowledge, and 31% (95% CI 23.8%–39.2%) for self‐declared behaviour among prescribers, 18% (95% CI 12.8%–25.8%) for awareness, 7% (95% CI 3.7%–12.7%) for knowledge, and 50% (95% CI 41.7%–58.3%) for self‐declared behaviour among pharmacists, and 29% (95% CI 21.6%–36.6%) for awareness, and 3% (95% CI 1.1%–7.6%) for knowledge among patients. Overall success was not attained by any target population.ConclusionsRMM were evaluated as not effective across outcomes of awareness, knowledge, and self‐declared behaviour in prescribers, pharmacists, and patients. Findings suggested we need continued efforts for RMM across all target populations and across all outcomes.
Setting standards for SDLMI fidelity: Promoting Data‐driven decision making to advance Self‐determination instruction
Authors: Shogren Karrie A. , Pace Jesse R. , Hicks Tyler A. , Raley Sheida K. , Lane Kathleen Lynne 
Published: September 2023

AbstractThis study used the standard setting to establish cutscores for the fidelity of implementation of an evidence‐based intervention, the Self‐Determined Learning Model of Instruction (SDLMI) designed to enhance goal‐directed actions in secondary students with and without disabilities. Cutscores were then applied to fidelity data from a large, randomized trial of the SDLMI with teacher implementers. Findings suggest teachers demonstrate a range of fidelity outcomes over time across three dimensions adherence, quality of delivery, and student responsiveness. Almost all teachers (93%) immediately meet cutscores for the adherence dimension after training, but smaller numbers meet cutscores for quality of delivery (64%) and student responsiveness (69%). However, the quality of delivery and student responsiveness showed growth over time with implementation experience and there was a small effect of intensifying implementation support.
Green Synthesis of CdS/CISe Core‐Shell Structured Quantum Dots and Their Photovoltaic Applications
Authors: Zhang Jiapeng , Zhang Hui , Du Qinghua , Xie Xinjian , Fang Yi , Tang Chengchun , Chen Guifeng 
Published: September 2023

AbstractQuantum dots (QDs) of I‐III‐VI2 ternary compounds, such as CuInSe2 (CISe) and CuInS2 (CIS), have broad application prospects as light‐absorbing layers in solar cells due to their excellent photoelectric properties. Nevertheless, the presence of large numbers of surface defects in quantum dots will affect their performance. In this study, inverted type‐I CdS/CISe core‐shell QDs are successfully synthesized through thermal injection method in triethylene glycol, which is green and safe. By changing the molar ratios of CdS and CISe QDs, the components and optical properties of core‐shell QDs are intensively studied by using different characterization methods (XRD, TEM, EDS, UV–vis, Raman, and fluorescence spectrum). The solar cells with the structure of FTO/TiO2/CdS/CdS/CISe/Mo are assembled, where the CdS/CISe core‐shell QDs are used as absorption layers. The prepared devices exhibit an efficiency of 1.01% under an AM 1.5 G spectrum with a light intensity of 100 mW cm−2.
The effects of purslane (Portulaca oleracea) on glycemic indices: A GRADE‐assessed systematic review and meta‐analysis of randomized controlled trials
Authors: Abbasi Shaghayegh , Mashatan Noushin , Farmani Elahe , Khodashenas Mehran , Musazadeh Vali , Ahrabi Sana Sedgh , Moridpour Amir Hossein , Faghfouri Amir Hossein 
Published: September 2023

AbstractAlthough several studies have revealed the benefits of purslane on glycemic indices, the results of some studies reject such effect. Therefore, aim of this meta‐analysis of randomized controlled trials (RCTs) was to assess the effects of purslane supplementation on glycemic indices. Scientific international databases as Scopus, Web of Sciences, PubMed, Embase, and the Cochrane library were searched up to December 2022. For net changes in glycemic indices, weighted mean differences (WMDs) were calculated using random‐effects models. Purslane supplementation had a statistically significant reduction in fasting blood glucose [FBG, WMD: −6.37; 95% CI: −9.34, −3.40, p < 0.001]. In addition, purslane did not significant effect on serum levels of insulin [WMD: −0.74; 95% CI: −2.58, 1.10; p = 0.430], homeostasis model assessment for insulin resistance [HOMA‐IR, WMD: −0.25; 95% CI: −0.88, 0.37, p = 0.429], and QUICKI [WMD: −0.01; 95% CI: −0.01, 0.03, p = 0.317] compared with the control group. The results of our meta‐analysis revealed a beneficial effect of purslane supplementation as a tool to decrease FBG levels, but not to HOMA‐IR, insulin, and QUICKI levels. However, future high‐quality, long‐term clinical trials are needed to confirm our results.