bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do intangible assets help SMEs in underdeveloped markets gain access to external finance?—the case of Vietnam
Authors: Le Chau , Nguyen Bach , Vo Vinh 
Published: May 2023

AbstractThe credit frictions encountered by small and medium-sized enterprises (SMEs) have been widely examined in the entrepreneurship literature. Although theory suggests that asset tangibility helps increase firms’ borrowing capacity because it allows creditors to take possession of a firm’s assets more easily, this paper provides new evidence about the role of intangible assets in reducing credit frictions for SMEs. Using an extensive dataset of more than 155,852 SMEs in Vietnam and a multivariate probit model, we find that identifiable intangible assets improve firm access to debt and equity finance. Interestingly, it is found that the friction-reducing effect of intangibles is stronger on debt finance than on equity finance, suggesting non-equivalent distributional effects of intangible assets on firm capital structure. Moreover, firm age and size can moderate the association between intangibles and access to the two sources of external finance.
Situation-Based Connexive Logic
Authors: Giordani Alessandro 
Published: May 2023

AbstractThe aim of this paper is to present a system of modal connexive logic based on a situation semantics. In general, modal connexive logics are extensions of standard modal logics that incorporate Aristotle’s and Boethius’ theses, that is the thesis that a sentence cannot imply its negation and the thesis that a sentence cannot imply a pair of contradictory sentences. A key problem in devising a connexive logic is to come up with a system that is both sufficiently strong to fulfill some specific connexive theses and sufficiently well-motivated from a semantical point of view. The approach proposed here tries to address this problem by defining an appropriate connexive relation in terms of more basic notions. The result is a well-motivated system of modal connexive logic that nicely fits in both with the traditional ideas concerning the connexive conditional and with the current developments in connexive logic.
The potential oncogenic effect of tissue-specific expression of JC polyoma T antigen in digestive epithelial cells
Authors: Zheng Hua-chuan , Xue Hang , Sun Hong-zhi , Yun Wen-jing , Cui Zheng-guo 
Published: May 2023

AbstractJC polyoma virus (JCPyV), a ubiquitous polyoma virus that commonly infects people, is identified as the etiologic factor for progressive multifocal leukoencephalopathy and has been closely linked to various human cancers. Transgenic mice of CAG-loxp-Laz-loxp T antigen were established. T-antigen expression was specifically activated in gastroenterological target cells with a LacZ deletion using a cre-loxp system. Gastric poorly-differentiated carcinoma was observed in T antigen-activated mice using K19-cre (stem-like cells) and PGC-cre (chief cells), but not Atp4b-cre (parietal cells) or Capn8-cre (pit cells) mice. Spontaneous hepatocellular and colorectal cancers developed in Alb-cre (hepatocytes)/T antigen and villin-cre (intestinal cells)/T antigen transgenic mice respectively. Gastric, colorectal, and breast cancers were observed in PGC-cre/T antigen mice. Pancreatic insulinoma and ductal adenocarcinoma, gastric adenoma, and duodenal cancer were detected in Pdx1-cre/T antigen mice. Alternative splicing of T antigen mRNA occurred in all target organs of these transgenic mice. Our findings suggest that JCPyV T antigen might contribute to gastroenterological carcinogenesis with respect to cell specificity. Such spontaneous tumor models provide good tools for investigating the oncogenic roles of T antigen in cancers of the digestive system.
Short-term residential exposure to air pollution and risk of acute myocardial infarction deaths at home in China
Authors: Cheng Jian , Zheng Hao , Wei Jing , Huang Cunrui , Ho Hung Chak , Sun Shengzhi , Phung Dung , Kim Ho , Wang Xiling , Bai Zhongliang , Hossain Mohammad Zahid , Tong Shilu , Su Hong , Xu Zhiwei 
Published: May 2023

AbstractAir pollution remains a major threat to cardiovascular health and most acute myocardial infarction (AMI) deaths occur at home. However, currently established knowledge on the deleterious effect of air pollution on AMI has been limited to routinely monitored air pollutants and overlooked the place of death. In this study, we examined the association between short-term residential exposure to China’s routinely monitored and unmonitored air pollutants and the risk of AMI deaths at home. A time-stratified case-crossover analysis was undertaken to associate short-term residential exposure to air pollution with 0.1 million AMI deaths at home in Jiangsu Province (China) during 2016–2019. Individual-level residential exposure to five unmonitored and monitored air pollutants including PM1 (particulate matter with an aerodynamic diameter ≤ 1 μm) and PM2.5 (particulate matter with an aerodynamic diameter ≤ 2.5 μm), SO2 (sulfur dioxide), NO2 (nitrogen dioxide), and O3 (ozone) was estimated from satellite remote sensing and machine learning technique. We found that exposure to five air pollutants, even below the recently released stricter air quality standards of the World Health Organization (WHO), was all associated with increased odds of AMI deaths at home. The odds of AMI deaths increased by 20% (95% confidence interval: 8 to 33%), 22% (12 to 33%), 14% (2 to 27%), 13% (3 to 25%), and 7% (3 to 12%) for an interquartile range increase in PM1, PM2.5, SO2, NO2, and O3, respectively. A greater magnitude of association between NO2 or O3 and AMI deaths was observed in females and in the warm season. The greatest association between PM1 and AMI deaths was found in individuals aged ≤ 64 years. This study for the first time suggests that residential exposure to routinely monitored and unmonitored air pollutants, even below the newest WHO air quality standards, is still associated with higher odds of AMI deaths at home. Future studies are warranted to understand the biological mechanisms behind the triggering of AMI deaths by air pollution exposure, to develop intervention strategies to reduce AMI deaths triggered by air pollution exposure, and to evaluate the cost-effectiveness, accessibility, and sustainability of these intervention strategies.
Graphical abstract
Reduction of Pain After Laparoscopic Bariatric Surgery by Personalized Checkpoint Acupuncture—Data of a STRICTA Conform Pilot Study
Authors: Ghanad Erfan , Staff Sophie , Weiß Christel , Goncalves Mario , Santos Maria Joao , Correia Nuno , Vassilev Georgi , Herrle Florian , Reissfelder Christoph , Greten Henry Johannes , Otto Mirko , Yang Cui 
Published: May 2023

Abstract
Background

It
remains challenging in clinical practice to perform optimal pain management following bariatric surgeries. Acupuncture (AC) is an effective method of postoperative pain management, but its clinical efficacy depends on the rationale used to select AC points.

Methods
We developed a method to identify individual patterns of pain and a corresponding set of acupoints (corrAC) based on the relative pressure sensitivity of six abdominal visceral pressure points, i.e., the gastrointestinal (GI) checkpoints (G1–G6). Patients with moderate to severe pain were included and received a single AC treatment following surgery. The visual analog scale (VAS) score, pain threshold, and skin temperature were assessed before AC and at 5 min, 1 h, and 24 h following AC. AC was performed with 1-mm-deep permanent needles.

Results
From April 2021 to March 2022, 72 patients were included in the analysis. Fifty-nine patients received corrAC, whereas 13 received a noncorresponding AC (nonAC) as an internal control. Patients receiving corrAC showed a significant reduction (74%) in pain at 5 min after treatment (p < 0.0001) and a significant increase (37%) in the pain threshold (p < 0.0001). In this group, a significant increase in skin temperature above G1, G3, G4, and G5 was observed. Patients receiving nonAC showed neither significant pain reduction nor significant changes in pain threshold. The skin above G3 and G4 did not reveal temperature changes.

Conclusion
Checkpoint AC may be an effective tool in postoperative pain therapy after bariatric surgery. Vegetative functional involvement might be associated with pain relief.

Graphical Abstract
The Care-Dependent are Less Averse to Care Robots: An Empirical Comparison of Attitudes
Authors: Schönmann Manuela , Bodenschatz Anja , Uhl Matthias , Walkowitz Gari 
Published: May 2023

AbstractA growing gap is emerging between the supply of and demand for professional caregivers, not least because of the ever-increasing average age of the world’s population. One strategy to address this growing gap in many regions is the use of care robots. Although there have been numerous ethical debates about the use of robots in nursing and elderly care, an important question remains unexamined: how do the potential recipients of such care perceive situations with care robots compared to situations with human caregivers? Using a large-scale experimental vignette study, we investigated people’s affective attitudes toward care robots. Specifically, we studied the influence of the caregiver’s nature on participants’ perceived comfort levels when confronted with different care scenarios in nursing homes. Our results show that the care-robot-related views of actual care recipients (i.e., people who are already affected by care dependency) differ substantially from the views of people who are not affected by care dependency. Those who do not (yet) rely on care placed care robots’ value far below that of human caregivers, especially in a service-oriented care scenario. This devaluation was not found among care recipients, whose perceived level of comfort was not influenced by the caregiver’s nature. These findings also proved robust when controlled for people’s gender, age, and general attitudes toward robots.
BDNF and KISS-1 Levels in Maternal Serum, Umbilical Cord, and Placenta: The Potential Role of Maternal Levels as Effect Biomarker
Authors: Granitzer Sebastian , Widhalm Raimund , Atteneder Simon , Fernandez Mariana F. , Mustieles Vicente , Zeisler Harald , Hengstschläger Markus , Gundacker Claudia 
Published: May 2023

AbstractBrain-derived neurotrophic factor (BDNF) and kisspeptin-1 (KISS-1) regulate placental development and fetal growth. The predictive value of maternal serum BDNF and KISS-1 concentrations for placental and umbilical cord levels has not yet been explored. The influence of prenatal lead (Pb) and cadmium (Cd) exposure and maternal iron status on BDNF and KISS-1 levels is also unclarified and of concern. In a pilot cross-sectional study with 65 mother–newborn pairs, we analyzed maternal and cord serum levels of pro-BDNF, mature BDNF, and KISS-1, BDNF, and KISS-1 gene expression in placenta, Pb and Cd in maternal and umbilical cord blood (erythrocytes), and placenta. We conducted a series of in vitro experiments using human primary trophoblast cells (hTCs) and BeWo cells to verify main findings of the epidemiological analysis. Strong and consistent correlations were observed between maternal serum levels of pro-BDNF, mature BDNF, and KISS-1 and corresponding levels in umbilical serum and placental tissue. Maternal red blood cell Pb levels were inversely correlated with serum and placental KISS-1 levels. Lower expression and release of KISS-1 was also observed in Pb-exposed BeWo cells. In vitro Pb exposure also reduced cellular BDNF levels. Cd-treated BeWo cells showed increased pro-BDNF levels. Low maternal iron status was positively associated with low BDNF levels. Iron-deficient hTCs and BeWo cells showed a consistent decrease in the release of mature BDNF. The correlations between maternal BDNF and KISS-1 levels, placental gene expression, and umbilical cord serum levels, respectively, indicate the strong potential of maternal serum as predictive matrix for BDNF and KISS-1 levels in placentas and fetal sera. Pb exposure and iron status modulate BDNF and KISS-1 levels, but a clear direction of modulations was not evident. The associations need to be confirmed in a larger sample and validated in terms of placental and neurodevelopmental function.
Boundary resource management in innovation ecosystems: The case of e-commerce
Authors: Wulfert Tobias 
Published: May 2023

AbstractMajor challenges in contemporary information systems development demand new development approaches, such as innovation ecosystems, consisting of a focal innovation platform surrounded by independent developers. The attraction of third-party developers and the amplification of generativity in extension development call for sophisticated boundary resources. As demarcation points between an innovation platform and external developers, boundary resources entail a strategic value and need to be managed carefully. However, existing research does not provide an approach for the holistic management of boundary resources from design to retirement. We apply a design science research approach consisting of two design cycles involving a literature review identifying 26 application lifecycles and the analysis of eight innovation platforms in e-commerce. We evaluated the model for boundary resource management in interviews with nine domain experts. We develop an integrated boundary resource management lifecycle as a specialization of application lifecycle management for the holistic management of boundary resources in innovation ecosystems addressing third-party developers. The boundary resource management lifecycle consists of four layers: boundary resource governance, continuous communication, technical boundary resources, and supplementary boundary resources. It decouples technical and supplementary boundary resources while emphasizing their intertwined nature for ecosystem participants. Owners of innovation platforms can instantiate the reference procedure model for attracting developers.
Effect of aluminum nanoparticle size on phase transitions: a molecular dynamics study
Authors: Arellano-Ramírez I. D. , Ladino E. A. Hincapie , Restrepo-Parra E. 
Published: May 2023

AbstractIsothermal molecular dynamics simulations were carried out with the embedded-atom method as a potential to predict the melting and crystallization temperatures of nanometric sized aluminum particles in the range of $$2$$

2

–$$4 \mathrm{nm}$$

4
nm

. Simulated data predicted a decrease in the melting point $${T}_{m}$$

T
m

of aluminum nanoparticles with an increase in their inverse radius $${r}^{-1}$$

r

-
1

according to an almost linear law. The data obtained predicted a higher value of melting temperature compared to crystallization by $$\Delta T=272 \mathrm{K}$$

Δ
T
=
272
K

for a size of $$4\mathrm{ nm}$$

4
nm

and, $$\Delta T=193 K$$

Δ
T
=
193
K

for $$2\mathrm{ nm}$$

2
nm

. The $${T}_{m}$$

T
m

of the nanoparticles augmented with increasing size, from $$720 K$$

720
K

for $$2 \mathrm{nm}$$

2
nm

to $$827 \mathrm{K}$$

827
K

for $$4\mathrm{ nm}$$

4
nm

. Furthermore, a linear extrapolation of the $${T}_{m}$$

T
m

as a function of the inverse of the cubic root of the number of atoms yielded a melting temperature of aluminum of $$947 \pm 8 \mathrm{K}$$

947
±
8
K

, which is similar to previous estimations. Finally, when the number of atoms increased the number of face-centered cubic (FCC) structural units also increased, and the amorphous structure decreased.
Mindfulness in Politics: A Qualitative Study on Mindfulness Training in the UK Parliament
Authors: Simonsson Otto , Bergljottsdotter Christine , Narayanan Jayanth , Fisher Stephen , Bristow Jamie , Ormston Ruth , Chambers Richard 
Published: May 2023

Abstract
Objectives
While mindfulness in the workplace has received substantial scientific attention in the past decades, it is not yet well-understood if, under what circumstances, and in what ways mindfulness training may be helpful for individuals working in political environments. The aim of this study was to explore the experience of mindfulness training among British politicians, as well as mindfulness facilitators who had taught mindfulness to politicians in the UK Parliament.

Method
Between September and November 2021, semi-structured in-depth interviews were conducted with British politicians (n = 18) who had experience of mindfulness training and mindfulness facilitators (n = 4) who had taught mindfulness to politicians in the UK Parliament. The interview material was analyzed using reflexive thematic analysis.

Results
Two main themes related to the experience of mindfulness training in politics were developed during the analytic process: (1) mindfulness approaches addressing particular challenges in political work, and (2) mindfulness sessions and group dynamics. Taken together, mindfulness training helped the politicians to better deal with the demands and stresses of political work, to reconnect with themselves and be more grounded, and – especially when taught in a group setting – to relate to other politicians and their viewpoints in a more humane and constructive way.

Conclusions
The results suggest that mindfulness training can be beneficial at both the personal and professional level for individuals working in political contexts, which can provide a rationale for governments to introduce mindfulness-based programs to politicians.
Study on the Propagation and Focusing Mechanism of Long Waves over A Submerged Atoll
Authors: Fu Dan-juan , Liu Bi-jin , Zheng Jin-hai , Wang Gang , Chen Bi-qin 
Published: May 2023

AbstractAn analytical solution for long waves propagating over a submerged atoll is established. The atolls involved in this study are annular coral reefs with large lagoons in the middle, and the expression of the cross section is a trinomial function of the radial distance, i.e., h=ar2s−brs+h0, where s is the positive rational number. This analytical solution extends the theory by Wang et al. (2018) as s is no longer limited to s=2/m, where m is the positive integer. In addition, by adjusting the terrain parameters properly, the analytic solution can be degenerated to describe the wave propagation over topography with a hump or pit. According to the relationship between wave rays and wave energy, the distribution characteristics and formation mechanism of energy over the topography are expounded. When the lagoon is non-existent, all wave rays converge at the x-axis, which results in an abrupt amplification of the wave amplitude around the convergence point. When a lagoon is mounted on the top of the atoll, the rays are scattered due to the refraction of the lagoon, and only some rays converge at the symmetrical axis and the ridges on both sides, which results in the amplification of wave amplitudes in these areas.
Multi-functional auto-fluorescent nanogels for theranostics
Authors: Vashist Arti , Raymond Andrea D. , Chapagain Prem , Vashist Atul , Arias Adriana Yndart , Kolishetti Nagesh , Nair Madhavan 
Published: May 2023

AbstractHere in the present article, the state of art for nanotechnology-enabled nanogel theranostics and the upcoming concepts in nanogel-based therapeutics are summarized. The benefits, innovation, and prospects of nanogel technology are also briefly presented.
Bacterial cell-free metabolites-based zinc oxide nanoparticles for combating skin-causing bacterial infections
Authors: Hemdan Bahaa A. , El-Naggar Mehrez E. , Abd-Elgawad Sh. E. , El Zawawy Nessma A. , Mahmoud Yehia A.-G. 
Published: May 2023

AbstractRecently, the development of skin barrier depend on wound healing, which is one of the most complicated biological processes. As an alternative to conventional antibiotics, nanoparticles (NPs) have become more utilized generally to attack bacteria. Due to their distinct characteristics, potential microbicidal action, and ability to speed up the wound healing process, zinc oxide nanoparticles (ZnO-NPs) have attracted much attention. Biological techniques can solve the restrictions of both physical and chemical approaches for nanoparticles synthesis. Because it does not require expensive chemicals, high temperatures, or a lot of time, biological synthesis is relatively easy, inexpensive, and environmentally benign. The secondary metabolic extract from Escherichia coli was used in this study to biologically synthesize three distinct quantities of ZnO-NPs, which were then assessed for their effectiveness in wound healing and bacterial infection prevention. The biofabricated ZnO-NPs were fully characterized in terms of particle shape, morphology, and stability against aggregation. Depending on the concentration of the utilized zinc salt, three different samples were fabricated biologically, nominated as ZnO-NPs-1, ZnO-NPs-2, and ZnO-NPs-3. The findings of Uv-vis absorption peaks were obtained at 352 nm, demonstrating the preparation of ZnO-NPs. The results demonstrated the formation of ZnO-NPs with an average particle size of 79.19, 79.83 and 91.57 nm for the three prepared samples (ZnO-NPs-1, ZnO-NPs-2, and ZnO-NPs-3), respectively. Additionally, these samples of ZnO-NPs exhibited zeta potential values around −34.3, −33.7, and −33.4 mV, respectively. Energy dispersive X-ray confirmed the successful formation of ZnO-NPs. It was also observed from the obtained results that, ZnO-NP-3 showed superior antimicrobial potential against selected skin infectious microbes. The effective killing dosage of ZnO-NPs-3 was recorded to be 40 mg/L which can eliminate microbial growth. The dysregulation of skin flora significantly influences the etiology of inflammatory skin disorders.
Modelling as a process
Authors: Vieira Kritz Maurício 
Published: May 2023

AbstractBroadly speaking, models are representations of something concrete or not. In science, models have always a purpose related to understanding and explaining phenomena. This requires focus and selecting what to represent and what not to represent and how to represent, among other things. Thus, a side effect of developing the scientific method is the development of a well-structured modelling paradigm. Starting from phenomena and objects, I discuss many decision-abstraction steps in the modelling process that leads to models of phenomena expressed mathematically or computationally, highlighting underlining contexts and procedures. This discourse is undertaken centred on a cross- and trans-disciplinary system science perspective. It grounds on a personal perspective and may be considered as a model of the modelling process.
Swarming Responsive Photonic Nanorobots for Motile-Targeting Microenvironmental Mapping and Mapping-Guided Photothermal Treatment
Authors: Li Luolin , Yu Zheng , Liu Jianfeng , Yang Manyi , Shi Gongpu , Feng Ziqi , Luo Wei , Ma Huiru , Guan Jianguo , Mou Fangzhi 
Published: May 2023

AbstractMicro/nanorobots can propel and navigate in many hard-to-reach biological environments, and thus may bring revolutionary changes to biomedical research and applications. However, current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments. Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment. The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe3O4 nanoparticles encapsulated in a responsive hydrogel shell, and show multiple integrated functions, including energetic magnetically-driven swarming motions, bright stimuli-responsive structural colors, and photothermal conversion. Thus, they can actively navigate in complex environments utilizing their controllable swarming motions, then visualize unknown targets (e.g., tumor lesion) by collectively mapping out local abnormal physicochemical conditions (e.g., pH, temperature, or glucose concentration) via their responsive structural colors, and further guide external light irradiation to initiate localized photothermal treatment. This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflammatory diseases.