bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Plant Materials as a Source of Neuroprotective Peptides
Authors: Skibska Agnieszka , Perlikowska Renata 
Published: July 2023

:
In many circumstances, some crucial elements of the neuronal defense system
fail, slowly leading to neurodegenerative diseases. Activating this natural process by administering
exogenous agents to counteract unfavourable changes seems promising.
Therefore, looking for neuroprotective therapeutics, we have to focus on compounds that
inhibit the primary mechanisms leading to neuronal injuries, e.g., apoptosis, excitotoxicity,
oxidative stress, and inflammation. Among many compounds considered neuroprotective
agents, protein hydrolysates and peptides derived from natural materials or their synthetic
analogues are good candidates. They have several advantages, such as high selectivity
and biological activity, a broad range of targets, and high safety profile. This review
aims to provide biological activities, the mechanism of action and the functional
properties of plant-derived protein hydrolysates and peptides. We focused on their significant
role in human health by affecting the nervous system and having neuroprotective
and brain-boosting properties, leading to memory and cognitive improving activities. We
hope our observation may guide the evaluation of novel peptides with potential neuroprotective
effects. Research into neuroprotective peptides may find application in different
sectors as ingredients in functional foods or pharmaceuticals to improve human health
and prevent diseases.
Novel Approaches to the Management of Diabetes Mellitus in Patients with
Coronary Artery Disease
Authors: Oikonomou Evangelos , Xenou Maria , Zakynthinos George E. , Tsaplaris Paraskevas , Lampsas Stamatios , Bletsa Evanthia , Gialamas Ioannis , Kalogeras Konstantinos , Goliopoulou Athina , Gounaridi Maria I. , Pesiridis Theodoros , Tsatsaragkou Aikaterini , Vavouranakis Manolis , Siasos Gerasimos , Tousoulis Dimitris 
Published: July 2023

Abstract:
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in individuals with diabetes
mellitus (DM). Although benefit has been attributed to the strict control of hyperglycemia with traditional
antidiabetic treatments, novel antidiabetic medications have demonstrated cardiovascular (CV) safety and benefits
by reducing major adverse cardiac events, improving heart failure (HF), and decreasing CVD-related mortality.
Emerging data underline the interrelation between diabetes, as a metabolic disorder, and inflammation,
endothelial dysfunction, and oxidative stress in the pathogenesis of microvascular and macrovascular complications.
Conventional glucose-lowering medications demonstrate controversial CV effects. Dipeptidyl peptidase-
4 inhibitors have not only failed to prove to be beneficial in patients with coronary artery disease, but also
their safety is questionable for the treatment of patients with CVD. However, metformin, as the first-line option
for type 2 DM (T2DM), shows CVD protective properties for DM-induced atherosclerotic and macrovascular
complications. Thiazolidinedione and sulfonylureas have questionable effects, as evidence from large studies
shows a reduction in the risk of CV events and deaths, but with an increased rate of hospitalization for HF.
Moreover, several studies have revealed that insulin monotherapy for T2DM treatment increases the risk of major
CV events and deaths from HF, when compared to metformin, although it may reduce the risk of myocardial
infarction. Finally, this review aimed to summarize the mechanisms of action of novel antidiabetic drugs
acting as glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors that show favorable
effects on blood pressure, lipid levels, and inflammation, leading to reduced CVD risk in T2DM patients.
Understanding the Artemia Salina (Brine Shrimp) Test: Pharmacological
Significance and Global Impact
Authors: Olmedo Dionisio A. , Vasquez Yelkaira , Morán Juan Antonio , De León Estela Guerrero , Caballero-George Catherina , Solís Pablo N. 
Published: July 2023

Background:
The microplate benchtop brine shrimp test (BST) has been widely used
for screening and bio-guided isolation of many active compounds, including natural products. Although
the interpretation given to the results appears dissimilar, our findings suggest a correlation
between positive results with a specific mechanism of action.

Objective:
This study aimed to evaluate drugs belonging to fifteen pharmacological categories having
diverse mechanisms of action and carry out a bibliometric analysis of over 700 citations related
to microwell BST.

Methods:
Test compounds were evaluated in a serial dilution on the microwell BST using healthy
nauplii of Artemia salina and after 24 hrs of exposition, the number of alive and dead nauplii was
determined, and the LC50 was estimated. A metric study regarding the citations of the BST miniaturized
method, sorted by type of documents cited, contributing country, and interpretation of results
was conducted on 706 selected citations found in Google Scholar.

Results:
Out of 206 drugs tested belonging to fifteen pharmacological categories, twenty-six
showed LC50 values <100 μM, most of them belonging to the category of antineoplastic drugs;
compounds with different therapeutical uses were found to be cytotoxic as well. A bibliometric
analysis showed 706 documents citing the miniaturized BST; 78% of them belonged to academic
laboratories from developing countries located on all continents, 63% interpreted their results as
cytotoxic activity and 35% indicated general toxicity assessment.

Conclusion:
BST is a simple, affordable, benchtop assay, capable of detecting cytotoxic drugs
with specific mechanisms of action, such as protein synthesis inhibition, antimitotic, DNA binding,
topoisomerase I inhibitors, and caspases cascade interfering drugs. The microwell BST is a technique
that is used worldwide for the bio-guided isolation of cytotoxic compounds from different
sources.
Calixarenes and their Relevance in Anticancer Drug Development
Authors: Paul Soumyajeet , Jeyaprakash Ramaiah Selladurai , Pai Aravinda , Venkatachalam Hillemane , Jayashree Bellur Srinivas 
Published: July 2023

Abstract:
Calixarenes have always captured the attention of several researchers. They have the
ability to entrap multiple molecules and form inclusion complexes with drugs due to their unique
structure. Due to this property, they are being widely used in the development of several classes of
drugs, most notably anticancer drugs. This review attempted to summarize the potential applications
of calixarenes and its derivatives in the development of anticancer drugs, with a focus on the delivery
of drug classes such as DNA intercalators, taxanes, DNA alkylators, and topoisomerase inhibitors.
Calixarene-based macromolecular chemistry could therefore have a high potential for overcoming
the toxicity of cancer chemotherapy and achieving targeted drug delivery.
Computational Studies and Antimicrobial Activity of 1-(benzo[d]oxazol-2-
yl)-3,5-diphenylformazan Derivatives
Authors: Almehmadi Mazen , Alsaiari Ahad Amer , Allahyani Mamdouh , Alsharif Abdulaziz , Aljuaid Abdulelah , Saha Supriyo , Asif Mohammad 
Published: July 2023

Background:
Due to the biological importance of the benzoxazole derivatives, some 1-
(benzo[d]oxazol-2-yl)-3,5-diphenyl-formazans 4a-f were synthesized and screened for in-silico
studies and in-vitro antibacterial activity.

Methods:
The benzo[d]oxazole-2-thiol (1) was prepared by reacting with 2-aminophenol
and carbon disulfide in the presence of alcoholic potassium hydroxide. Then 2-hydrazinylbenzo[d]
oxazole (2) was synthesized from the reaction of compound 1 with hydrazine hydrate in the presence
of alcohol. Compound 2 was reacted with aromatic aldehydes to give Schiff base, 2-(2-
benzylidene-hydrazinyl)benzo[d]oxazole derivatives 3a-f. The title compounds, formazan derivatives
4a-f, were prepared by a reaction of benzene diazonium chloride. All compounds were confirmed
by their physical data, FTIR, 1H-NMR, and 13CNMR spectral data. All the prepared title
compounds were screened for in-silico studies and in-vitro antibacterial activity on various microbial
strains.

Results:
Molecular docking against the 4URO receptor demonstrated that molecule 4c showed a
maximum dock score of (-) 8.0 kcal/mol. MD simulation data reflected the stable ligand-receptor
interaction. As per MM/PBSA analysis, the maximum free binding energy of (-) 58.831 kJ/mol
was exhibited by 4c. DFT calculation data confirmed that most of the molecules were soft molecules
with electrophilic nature.

Conclusion:
The synthesized molecules were validated using molecular docking, MD simulation,
MMPBSA analysis, and DFT calculation. Among all the molecules, 4c showed maximum activity.
The activity profile of the synthesized molecules against tested micro-organisms was found to
be 4c>4b>4a>4e>4f>4d.
The Neuroanatomical Basis of the 5-HT Syndrome and Harmalineinduced
Tremor
Authors: Lalonde Robert , Strazielle Catherine 
Published: July 2023

Abstract:
The 5-HT syndrome in rats is composed of head weaving, body shaking, forepaw treading,
flat body posture, hindlimb abduction, and Straub tail. The importance of the brainstem and spinal
cord for the syndrome is underlined by findings of 5,7-dihydroxytryptamine (5,7-DHT)-induced denervation
supersensitivity in response to 5-HT-stimulant drugs. For head weaving and Straub tail, supersensitivity
occurred when the neurotoxin was injected into the cisterna magna or spinal cord, for
forepaw treading in cisterna magna, and for hindlimb abduction in the spinal cord. Although 5,7-
DHT-related body shaking increased in the spinal cord, the sign decreased when injected into the striatum,
indicating the modulatory influence of the basal ganglia. Further details on body shaking are provided
by its reduced response to harmaline after 5-HT depletion caused by intraventricular 5,7-DHT,
electrolytic lesions of the medial or dorsal raphe, and lesions of the inferior olive caused by systemic
injection of 3-acetylpyridine along with those found in Agtpbp1pcd or nr cerebellar mouse mutants. Yet
the influence of the climbing fiber pathway on other signs of the 5-HT syndrome remains to be determined.
Military history of the Kichuy fortification in the 18th century
Authors: Abdullin Khalim Minnullovich 
Published: July 2023

The identification, study and compilation of the most complete data on the history of fortifications on the territory of the Russian Federation remains one of the most pressing issues of modern historical science. The purpose of the study is to identify and analyze the data of historiography, cartographic and historical written sources on the history of the Kichuy fortification on the New Zakamye defensive line in the 18th century. An equally important task is to actualize interest in the history of fortifications of the 18th century, located on the territory of the Volga region and the Urals. A comprehensive approach based on the study of different types of sources has become the leading method for the study of this problem. Research materials: the work involves special historical studies (monographs and scientific articles), cartographic sources, legislative acts, business correspondence and published historical sources of the 18th century. Results and scientific novelty of the work: the facts of the wide use of the fortification Kichuy Feldshanets of the New Zakamye line during the Bashkir rebellion (1735–1740), the use of the Feldshanets as a strong point for the collection of troops in connection with the beginning of the Seven Years War (1756–1763), as well as during the suppression of the Pugachev rebellion (1773–1775) have been established. Mentions and descriptions of the Kichuy fortification were revealed in the works of P.I. Rychkov, P.S. Pallas, A.S. Pushkin, the facts of visiting the fortification by I.I. Neplyuev, P.S. Pallas, V.A. Kar, Ya.I. von Brandt. The materials of the article can be used in the preparation of generalizing monographs on the military history of the Russian Empire, in the teaching practice of universities when giving lectures and conducting practical classes, in the development of special courses on the history of fortification.
For citation: Abdullin Kh.M. Military history of the Kichuy fortification in the 18th century. From History and Culture of Peoples of the Middle Volga Region. 2023, vol.13, no.2, pp.10–20. https://doi.org/10.22378/2410-0765.2023-13-2.10-20 (In Russian)
Formación en Epidemiología: más allá de cuestiones metodológicas
Authors: Gallego Eraso Natalia Sofía 
Published: July 2023

La formación posgradual y la profundización en diferentes áreas del conocimiento se han convertido en uno de los elementos indispensables dentro de las instituciones de educación superior al representar la cualificación del docente y, como no, el aporte y avance del conocimiento. Además, dentro del proyecto de vida de una persona representan un aparente “estatus intelectual”, malinterpretado hoy en día porque el título tiene que “pesar” para entender la responsabilidad moral y social que conlleva. En Colombia, vivimos en el entorno de la “calidad” académica, donde la mercantilización de los títulos universitarios con discursos filantrópicos son vacíos en esencia y están caracterizados por praxis que no promueven el debate ideológico, social ni político, sino que, por el contrario, se justifican en bastos fundamentos típicos de las empresas comerciales. De acuerdo con el Consejo Nacional de Acreditación (CNA), a diferencia de otros países de América Latina, en Colombia, solo en los últimos cinco años, el número de programas de posgrado ha crecido más rápidamente en maestrías y en doctorados, en un contexto donde se ofertan bienes y servicios, en ocasiones, sin características diferenciadoras. Claramente, existe hoy en día una tendencia desmesurada de formación posgradual.
Root resorption during maxillary molar intrusion with clear aligners: a randomized controlled trial
Authors: Withayanukonkij Wisama , Chanmanee Pannapat , Promsawat Methee , Viteporn Smorntree , Leethanakul Chidchanok 
Published: July 2023

ABSTRACT

Objectives
To compare changes in maxillary molar root resorption, intrusion amount, dentoskeletal measures, and maximum bite force (MBF) between clear aligners (CA) and fixed appliances with miniscrew (FM) during molar intrusion.

Materials and Methods
Forty adults with anterior open bite were randomized into either CA or FM groups. Lateral cephalograms, cone-beam computed tomography (CBCT), and MBF were collected at pretreatment (T0) and 6 months of treatment (T1). Maxillary molar intrusion in FM were intruded by nickel-titanium (NiTi) closed-coil spring delivered force (150 grams/side) while clear aligners combined with squeezing exercise were performed in CA. Parametric tests were used for statistical analysis.

Results
After 6 months of treatment, significant root resorption of 0.21–0.24 mm in CA and 0.38–0.47 mm in FM were found while maxillary molars were intruded 0.68 and 1.49 mm in CA and FM, respectively. CA showed significant less root resorption and intrusion than FM. Overbite, bite closing, and MBF increased significantly. CA showed significantly less overbite and SN-MP changes but more MBF increase than FM. MBF in CA was correlated with the amount of maxillary molar intrusion (r = 0.736, P &lt; .05).

Conclusions
Maxillary molar intrusion and root resorption in CA were half the amount in FM in 6 months. The amount of maxillary molar root resorption was one-third of the intrusion distance. CA displayed less overbite increase and bite closing but more MBF increase than FM. MBF in CA was positively correlated with the molar intrusion amount.
History of the geological development of the Ukrainian sector of the Black Sea from the middle Early Cretaceous to the beginning of the Late Miocene
Authors: Stovba S. , Stephenson R. , Tyshchenko A. , Fenota P. , Vengrovych D. , Mazur S. 
Published: July 2023

Regional seismic investigations have made it possible to obtain new knowledge on the geological history of the Ukrainian sector of the Black Sea during rifting from Albian to Cenomanian, post-rift subsidence (Turonian¾Maastrichtian and Paleocene¾Middle Eocene), tectonic compression at the end of the middle Eocene and post-rift subsidence interrupted by a series of short-lived, compressional events (late Eocene ¾ the beginning of the Early Miocene). Rifting occurred simultaneously in the entire area of study and formed three long rift basins, each of which consisted of a system of (half)grabens, separated from each other and their margins by faults with amplitudes of up to3 km. The intensity of Cretaceous rifting was significantly less than would be required to produce continental lithosphere break-up and oceanic crust formation, or through-going «oceanisation» of continental lithosphere. Sedimentation during the pre-Late Eocene post-rift phase took place in relatively shallow marine conditions. Eocene compression caused a strong deformation of the sedimentary cover, partial and complete inversion of rift faults and the formation of three largely separate sea basins, between which a large landmass arose. The primary area of deposition of sedimentary sequences was significantly reduced due to strong deformations caused by compressional phases in the Late Miocene. That which is now the deep Black Sea was a relatively shallow basin until the beginning or even the end of the Pleistocene. Only thereafter did the water depth increase rapidly to more than 2 km. Research results indicate that modern tectonic reconstructions of the Western Black Sea and Eastern Black Sea basins, which are based on assumptions about the formation of the (sub)oceanic crust in these basins and/or different times of their formation, look unreliable. It also follows that any view of back-arc basins as small oceanic basins is not universally applicable.
Meningkatkan Minat Belajar Siswa Melalui Strategi Card Short Pada Materi Pelajaran Akidah Akhlak Sub Pelajaran Nama Dan Tugas Malaikat Allah Kelas IV SDI Manaratul ‘Ulum, Gandaria Utara, Jakarta Selatan
Authors: Muhyiddin Muhyiddin 
Published: July 2023

This research was conducted using the Card Short learning strategy to increase students’ learning interest at SDI Manaratul ‘Ulum, Gandaria Utara, Kebayoran Baru, South Jakarta. This type of research is called Classroom Action Research (CAR). The research subjects were class IV of SDI Manaratul ‘Ulum, Kebayoran Baru, South Jakarta, for the 2022/2023 academic year, with 20 students. This research was conducted in two cycles. Each process has four steps: the planning stage, the action implementation stage, the observation stage, and finally, the reflection stage. Before conducting the research, the highest % of students who were interested in learning the aqidah, morals, names, and duties of angels was 30%. After taking action, the results showed that in cycle 1, the percentage of interest in learning reached 70%, then it increased in cycle 2 to 85%. Based on these results, it can be concluded that the application of the Card Short strategy has a positive influence on increasing student learning interest in class IV SDI Manaratul ‘Ulum. So, the Card Short learning strategy can increase interest in learning the names and assignments of the angel of Allah for class IV SDI Manaratul ‘Ulum, Kebayoran Baru, South Jakarta. Interest in Learning, Card Short Strategy, Adding interest in learning

ABSTRAKPenelitian ini dilakukan dengan tujuan untuk mengetahui peningkatan minat belajar siswa SDI Manaratul ‘Ulum, Gandaria Utara, Kebayoran baru, Jakarta Selatan dengan menggunakan strategi pembelajaran Card Short. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Subjek penelitian adalah kelas IV SDI Manaratul ‘Ulum, Kebayoran Baru, Jakarta Selatan Tahun Pelajaran 2022/2023 sebanyak 20 siswa/i. Penelitian ini dilakukan dalam dua siklus. Pada setiap siklus terdapat empat langkah diantaranya yaitu tahap perencanaan, tahap pelaksanaan tindakan, tahap pengamatan, dan yang terakhir tahap refleksi. Sebelum melakukan penelitian, persentase minat belajar siswa dalam pelajaran akidah akhlak nama dan tugas malaikat tertinggi 30%. Setelah melakukan tindakan, hasil penelitian menunjukkan bahwa pada siklus 1, persentase minat belajar mencapai 70%, kemudian mengalami peningkatan pada ke siklus 2 menjadi 85%. Berdasarkan hasil tersebut, dapat disimpulkan bahwa penerapan strategi Card Short memberikan pengaruh positif terhadap peningkatan minat belajar siswa di kelas IV SDI Manaratul ‘Ulum. Jadi, strategi pembelajaran Card Short dapat meningkatkan minat belajar dalam nama dan tugas malaikat Allah kelas IV SDI Manaratul ‘Ulum, Kebayoran Baru, Jakarta Selatan. Minat Belajar, Strategi Card Short, Menambah minat belajar.
Kata Kunci: Minat Belajar, Strategi Card Short, Akidah Akhlak, Manaratul ‘Ulum
The effect of maturation conditions on physicochemical and viscoelastic properties of Kashkaval cheese
Authors: Pădureţ Sergiu 
Published: July 2023

Abstract
The equilibrium stress, decay stress, relaxation time, viscosity, modulus of elasticity, and decay modulus are major characteristics of viscoelastic food materials and therefore a modified mechanical model was used in this current research for the viscoelastic properties’ evaluation of Kashkaval cheese. Also, the chemical composition (fat content, moisture, protein content, water activity, salt, and acidity), and inside-outside color of the Kashkaval cheese were studied. From the analysis of stress relaxation curves the analyzed cheese samples fall into the category of viscoelastic solids with equilibrium stress greater than 0. The decay stress and decay modulus of the maturated unpacked samples showed the highest values of 36.31 kPa and 121.05 kPa, while the relaxation time of cheese samples was greater than 112.35 s. To evaluate the fit of the applied mechanical model to the experimental data the determination coefficient (R2 > 0.937) and the absolute average deviation coefficient were calculated (AAD < 10.324) and the evaluated cheeses’ parameters with the modified Maxwell model were at statistically appropriate levels.
Assessment of the Quality of Life Among Patients under Palliative Care
Authors: Statowski Wojciech Michał , Świętochowska Elżbieta 
Published: July 2023

Abstract

Background
Palliative care is a form of medical care that focuses on providing comfort and pain relief to patients with severe, incurable diseases. The World Health Organization defines quality of life as “an individual’s perception of their position in life in the context of culture and value systems in which they live and in relation to their goals, expectations, standards and concerns”. Quality of life and palliative medicine represent two aspects that should be inseparable in the comprehensive care and treatment of a patient at the end of life.

Objectives
The aim of this study was to assess quality of life among patients under palliative care using the WHOQOL-BREF and EQ-5D questionnaire.

Material and methods
The study included 100 consecutive patients admitted to palliative care between September 2018 and January 2019 being treated in a hospice and at home. A three-part survey process was used to collect data, including the following: Demographic Data Form; WHOQOL-BREF questionnaire; EQ-5D questionnaire.

Results
The WHOQOL-BREF questionnaire was analyzed for 4 domains. The study obtained the following results: Domain 1=40.2; Domain 2=39.94; Domain 3=36.1; Domain 4=37.7. According to the guidelines of the EQ-5D questionnaire, it was shown that 43% of patients are unable to walk or have serious problems with walking, 59% of patients are unable or have serious problems with self-care, 61% of patients are unable or have serious problems with ordinary activities, 52% of patients have severe or extreme pain/discomfort, 65% of patients are very anxious or depressed.

Conclusions
1. The study showed that patients covered by palliative care present low indicators of quality of life.
2. According to the data obtained, palliative care programs should pay special attention to the improvement of quality of life by taking an interdisciplinary approach to its resources.