bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of Weekly Electronic Patient- and Proxy-Reported Outcome Measures in Pediatric Oncology
Authors: Skrabal Ross Xiomara , Condon Paula , Yates Patsy , Walker Rick , Herbert Anthony , Bradford Natalie 
Published: May 2023

Background
Electronic patient-reported outcome measures (ePROMs) benefit adult cancer care, but their use in pediatric cancer care is limited.

Objectives
To explore the feasibility of collecting weekly ePROMs from pediatric cancer patients and/or their caregivers and to describe children’s levels of symptom burden, distress, and cancer-related quality of life.

Methods
A prospective and longitudinal cohort study was undertaken at one tertiary children’s cancer center. Children (2–18 years)/caregivers completed ePROMs with validated measures for distress, symptom burden, and cancer-related quality of life weekly for 8 weeks.

Results
Seventy children/caregivers participated in the study, and 69% completed ePROMs at all 8 weeks. Distress and cancer-related quality of life significantly improved over time. However, at week 8, almost half of the participants still reported high levels of distress. Symptom burden decreased over time, with the youngest and the oldest age groups (2–3 and 13–18 years) reporting the highest number of symptoms with severe burden.

Conclusions
Weekly collection of ePROMs in pediatric cancer care is feasible. Although distress, quality of life, and symptom burden improve over time, there is a need for timely assessment and interventions to improve symptoms, high levels of distress, and issues that negatively affect quality of life.

Implications for Practice
Nurses are ideally placed to intervene, assess, and monitor symptoms and to provide symptom management advice to pediatric cancer patients and caregivers. Findings from this study may inform the design of models of pediatric cancer care to improve communication with the healthcare team and patient experience of care.
MRT-ModSeq – Rapid detection of RNA modifications with MarathonRT
Authors: Araujo Tavares Rafael de Cesaris , Mahadeshwar Gandhar , Wan Han , Pyle Anna Marie 
Published: May 2023

SUMMARYChemical modifications are essential regulatory elements that modulate the behavior and function of cellular RNAs. Despite recent advances in sequencing-based RNA modification mapping, methods combining accuracy and speed are still lacking. Here, we introduce MRT- ModSeq for rapid, simultaneous detection of multiple RNA modifications using MarathonRT. MRT-ModSeq employs distinct divalent cofactors to generate 2-D mutational profiles that are highly dependent on nucleotide identity and modification type. As a proof of concept, we use the MRT fingerprints of well-studied rRNAs to implement a general workflow for detecting RNA modifications. MRT-ModSeq rapidly detects positions of diverse modifications across a RNA transcript, enabling assignment of m1acp3Y, m1A, m3U, m7G and 2’-OMe locations through mutation-rate filtering and machine learning. m1A sites in sparsely modified targets, such as MALAT1 and PRUNE1 could also be detected. MRT-ModSeq can be trained on natural and synthetic transcripts to expedite detection of diverse RNA modification subtypes across targets of interest.
A Conserved Core Region of the Scaffold NEMO is Essential for Signal-induced Conformational Change and Liquid-liquid Phase Separation
Authors: DiRusso Christopher J. , DeMaria Anthony M. , Wong Judy , Jordanides Jack J. , Whitty Adrian , Allen Karen N. , Gilmore Thomas D. 
Published: May 2023

AbstractScaffold proteins help mediate interactions between protein partners, often to optimize intracellular signaling. Herein, we use comparative, biochemical, biophysical, molecular, and cellular approaches to investigate how the scaffold protein NEMO contributes to signaling in the NF-κB pathway. Comparison of NEMO and the related protein optineurin from a variety of evolutionarily distant organisms revealed that a central region of NEMO, called the Intervening Domain (IVD), is conserved between NEMO and optineurin. Previous studies have shown that this central core region of the IVD is required for cytokine-induced activation of IκB kinase (IKK). We show that the analogous region of optineurin can functionally replace the core region of the NEMO IVD. We also show that an intact IVD is required for the formation of disulfide-bonded dimers of NEMO. Moreover, inactivating mutations in this core region abrogate the ability of NEMO to form ubiquitin-induced liquid-liquid phase separation droplets in vitro and signal-induced puncta in vivo. Thermal and chemical denaturation studies of truncated NEMO variants indicate that the IVD, while not intrinsically destabilizing, can reduce the stability of surrounding regions of NEMO, due to the conflicting structural demands imparted on this region by flanking upstream and downstream domains. This conformational strain in the IVD mediates allosteric communication between N- and C-terminal regions of NEMO. Overall, these results support a model in which the IVD of NEMO participates in signal-induced activation of the IKK/NF-κB pathway by acting as a mediator of conformational changes in NEMO.
The implementation of learning apps in biological education: a quantitative study of the current situation in Austria
Authors: Schmidthaler Eva , Hörmann Corinna , Rottenhofer Marina , Sabitzer Barbara , Lavicza Zsolt 
Published: May 2023

PurposeThis research paper aims to provide information about certified learning apps for biological education and gave an ordered list of all learning apps currently used by Austrian biology teachers in the classroom, which should serve as an overview for all biology teachers. In addition, the (currently little known) certification process of learning apps (seal of quality for educational applications) is described.Design/methodology/approachOnline questionnaire for all biology teachers throughout Austria, on the one hand to find out the apps, and on the other hand to research how Austrian teachers find suitable apps. The data were evaluated using descriptive statistics.FindingsA total of84 different learning apps are currently used by biology teachers in Austria. There are two certified lernapps in Austria, both are used. The most common app in biology lessons is “Anton”. The teachers find the information about apps throughout their own research or through colleagues. There are regional and school-specific differences in regards of usage and knowledge about seal of quality. It needs its own teacher training (TT) via suitable learning apps, because problems (data protection, advertising) are sometimes not taken into account during use.Research limitations/implicationsLimitations of this paper are that some of the teachers indicated the apps from other subjects (mathematics) to use this learning app, although this is not possible for biology lessons. Data protection was stated to the best of the authors’ knowledge by the authors, if the authors were not sure it says “unsure”. The participants are mainly women, but this corresponds to the gender ratio, which is typical of the Austrian teaching profession.Practical implicationsThe overview of the apps, compiled by this Austria-wide research, can be taken over into the biology lessons of all teachers. In addition, on the basis of this study, a TT at the University of Education 2023 in Linz was created. In addition, the (currently little known) certification process of learning apps is described.Social implicationsThe TT and the overview of the learning apps used serve as guidelines for teachers as to which apps they can use in biology lessons without hesitation. Above all, the aspect of the follow-up of digital media/apps will be emphasized. Data backup, inappropriate advertising must be processed in class or completely omitted. Biology teachers need the right training (TT) and appropriate materials and tools (apps) to reduce problems (cybercrimes).Originality/valueCurrently, there is no prepared list of suitable (certified and uncertified) learning apps for biology lessons. There are isolated recommendations and individual apps, but the selection criteria and backgrounds of the authors are not clear. This list shows which apps (how often) are used by which teachers. In addition, the (currently little known) certification process of learning apps is described.
The great Canadian recovery: The impact of COVID‐19 on Canada's labour market
Authors: Jones Stephen R.G. , Lange Fabian , Craig Riddell W. , Warman Casey 
Published: May 2023

AbstractThe Canadian labour market experienced a period of unprecedented turmoil following the onset of the COVID‐19 pandemic. We analyze the main changes using standard labour force statistics and new data on job postings. Envisaging a phase of temporary severing of employment relationships followed by a phase of more standard labour market search and matching, we use stock and flow data to understand key developments. We find dramatic changes in employment, unemployment and labour market attachment in the first few months of the pandemic and a broad though gradual recovery through to the end of 2021.
Investigation of the presence of specific neural antibodies in dogs with epilepsy or dyskinesia using murine and human assays
Authors: Hemmeter Lea , Bien Christian G. , Bien Corinna I. , Tipold Andrea , Neßler Jasmin , Bathen‐Nöthen Andrea , Matiasek Kaspar , Dahlhoff Maik , Rusbridge Clare , Rotter Black Carina , Rentmeister Kai , Volk Holger A. , Fischer Andrea 
Published: May 2023

AbstractBackgroundAutoimmune mechanisms represent a novel category for causes of seizures and epilepsies in humans, and LGI1‐antibody associated limbic encephalitis occurs in cats.Hypothesis/ObjectivesTo investigate the presence of neural antibodies in dogs with epilepsy or dyskinesia of unknown cause using human and murine assays modified for use in dogs.AnimalsFifty‐eight dogs with epilepsy of unknown cause or suspected dyskinesia and 57 control dogs.MethodsSerum and CSF samples were collected prospectively as part of the diagnostic work‐up. Clinical data including onset and seizure/episode type were retrieved from the medical records. Screening for neural antibodies was done with cell‐based assays transfected with human genes for typical autoimmune encephalitis antigens and tissue‐based immunofluorescence assays on mouse hippocampus slices in serum and CSF samples from affected dogs and controls. The commercial human und murine assays were modified with canine‐specific secondary antibody. Positive controls were from human samples.ResultsThe commercial assays used in this study did not provide unequivocal evidence for presence of neural antibodies in dogs including one dog with histopathologically proven limbic encephalitis. Low titer IgLON5 antibodies were present in serum from one dog from the epilepsy/dyskinesia group and in one dog from the control group.Conclusion and Clinical ImportanceSpecific neural antibodies were not detected using mouse and human target antigens in dogs with epilepsy and dyskinesia of unknown origin. These findings emphasize the need for canine‐specific assays and the importance of control groups.
Philosophy's past: Cognitive values and the history of philosophy
Authors: Corkum Phil 
Published: May 2023

AbstractRecent authors hold that the role of historical scholarship within contemporary philosophical practice is to question current assumptions, to expose vestiges or to calibrate intuitions. On these views, historical scholarship is dispensable, since these roles can be achieved by nonhistorical methods. And the value of historical scholarship is contingent, since the need for the role depends on the presence of questionable assumptions, vestiges or comparable intuitions. In this paper I draw an analogy between scientific and philosophical practice, in order to float one role for historical scholarship that is nonreplicable and noncontingent. It has long been acknowledged that cognitive values – features of theories that facilitate understanding, such as ontological parsimony, ideological simplicity, computational ease and fecundity – play a key role within science. The role of some of these values within philosophy also has received attention but left understudied are the values of novelty and conservativeness. These values influence theory choice, the selection of methodology, the setting of research agenda, and the presentation of results; and are best assessed with a historically informed evaluation. This role for historical scholarship is not replicable by nonhistorical methods, and is not contingent on the presence of questionable assumptions, vestiges or comparable intuitions.
Feasibility and Utility of a Fitbit Tracker Among Ambulatory Children and Youth With Disabilities
Authors: Bremer Emily , Arbour-Nicitopoulos Kelly P. , Tsui Brianna , Ginis Kathleen A. Martin , Moore Sarah A. , Best Krista L. , Voss Christine 
Published: May 2023

Purpose: To examine the feasibility and utility of the Fitbit Charge HR to estimate physical activity among ambulatory children and youth with disabilities. Method: Participants (4–17 y old) with disabilities were recruited and asked to wear a Fitbit for 28 days. Feasibility was assessed as the number of participants who adhered to the 28-day protocol. Heat maps were generated to visually examine variability in step count by age, gender, and disability group. Between-group differences for wear time and step counts by age, gender, and disability type were assessed by independent sample t tests for gender and disability group, and a 1-way analysis of variance for age group. Results: Participants (N = 157; median age = 10 y; 71% boys; 71% nonphysical disabilities) averaged 21 valid days of wear time. Wear time was higher in girls than boys (mean difference = 18.0; 95% confidence interval [CI], 6.8 to 29.1), and in preadolescents (mean difference = 27.6; 95% CI, 15.5 to 39.7) and adolescents (mean difference = −21.2; 95% CI, −33.6 to −8.7) than children. More daily steps were taken by boys than girls (mean difference = −1040; 95% CI, −1465 to −615) and individuals with a nonphysical disability than a physical disability (mean difference = −1120; 95% CI, −1474 to −765). The heat maps showed peaks in physical activity on weekdays before school, at recess, lunchtime, and after school. Conclusion: The Fitbit is a feasible tool for monitoring physical activity among ambulatory children and youth with disabilities and may be useful for population-level surveillance and intervention.
Uptake of four or more doses of sulfadoxine pyrimethamine for intermittent preventive treatment of malaria during pregnancy in Zambia: findings from the 2018 malaria in pregnancy survey
Authors: Sinyange Danny , Mukumbuta Nawa , Mutale Lwito Salifya , Mumbole Hudson , Hamainza Busiku , Sialubanje Cephas 
Published: May 2023

ObjectiveTo determine the prevalence and predictors of the uptake of four or more doses of sulfadoxine pyrimethamine (IPTp-SP 4+) in Zambia.DesignA cross-sectional study using secondary data from the malaria in pregnancy survey (Malaria Indicator Survey) data set conducted from April to May 2018.SettingThe primary survey was conducted at community level and covered all the 10 provinces of Zambia.ParticipantsA total of 3686 women of reproductive age (15–45 years) who gave birth within the 5 years before the survey.Primary outcomeProportion of participants with four or more doses of IPTp-SP.Statistical analysisAll analyses were conducted using RStudio statistical software V.4.2.1. Descriptive statistics were computed to summarise participant characteristics and IPTp-SP uptake. Univariate logistic regression was carried out to determine association between the explanatory and outcome variables. Explanatory variables with a p value less than 0.20 on univariate analysis were included in the multivariable logistic regression model and crude and adjusted ORs (aORs) along with their 95% CIs were computed (p<0.05).ResultsOf the total sample of 1163, only 7.5% of participants received IPTp-SP 4+. Province of residence and wealth tertile were associated with uptake of IPTp-SP doses; participants from Luapula (aOR=8.72, 95% CI (1.72 to 44.26, p=0.009)) and Muchinga (aOR=6.67, 95% CI (1.19 to 37.47, p=0.031)) provinces were more likely to receive IPTp-SP 4+ compared with to those from Copperbelt province. Conversely, women in the highest wealth tertile were less likely to receive IPTp-SP 4+ doses compared with those in the lowest quintile (aOR=0.32; 95% CI (0.13 to 0.79, p=0.014)).ConclusionThese findings confirm a low uptake of four or more doses of IPTp-SP in the country. Strategies should focus on increased coverage of IPTp-SP in provinces with much higher malaria burden where the risk is greatest and the ability to afford healthcare lowest.
Polychorous Puncture Vine Tribulus terrestris L. (Zygophyllaceae), a potential forage source for a guild of insect pollinators during the wet season
Authors: P. Suvarna Raju  , A.J. Solomon Raju  
Published: May 2023

Tribulus terrestris is a herbaceous weed capable of growing throughout the year in many habitats. It is hermaphroditic, protogynous, and self-pollinating, although it is also insect-pollinated. The insects involved in pollination use their flowers as a potential forage source by displaying fidelity during the wet season when profuse flowering occurs. The functional traits relating to sexual reproduction such as autonomous selfing, insect-pollination, polychory, and C4 photosynthetic pathway are quite advantageous for the plant to grow as a successful weed in different habitats, prominently in open habitats.
Red Blood Cell Transfusions Are Not Associated With Incident Complications or Poor Outcomes in Patients With Intracerebral Hemorrhage
Authors: Carvalho Poyraz Fernanda , Boehme Amelia , Cottarelli Azzurra , Eisler Lisa , Elkind Mitchell S. V. , Ghoshal Shivani , Agarwal Sachin , Park Soojin , Claassen Jan , Connolly E. Sander , Hod Eldad A. , Roh David J. 
Published: May 2023

Background
Anemia is associated with poor intracerebral hemorrhage (ICH) outcomes, yet the relationship of red blood cell (RBC) transfusions to ICH complications and functional outcomes remains unclear. We investigated the impact of RBC transfusion on hospital thromboembolic and infectious complications and outcomes in patients with ICH.

Methods and Results
Consecutive patients with spontaneous ICH enrolled in a single‐center, prospective cohort study from 2009 to 2018 were assessed. Primary analyses assessed relationships of RBC transfusions on incident thromboembolic and infectious complications occurring after the transfusion. Secondary analyses assessed relationships of RBC transfusions with mortality and poor discharge modified Rankin Scale score 4 to 6. Multivariable logistic regression models adjusted for baseline demographics and medical disease severity (Acute Physiology and Chronic Health Evaluation II), and ICH severity (ICH score).Of 587 patients with ICH analyzed, 88 (15%) received at least one RBC transfusion. Patients receiving RBC transfusions had worse medical and ICH severity. Though patients receiving RBC transfusions had more complications at any point during the hospitalization (64.8% versus 35.9%), we found no association between RBC transfusion and incident complications in our regression models (adjusted odds ratio [aOR], 0.71 [95% CI, 0.42–1.20]). After adjusting for disease severity and other relevant covariates, we found no significant association between RBC transfusion and mortality (aOR, 0.87 [95% CI, 0.45–1.66]) or poor discharge modified Rankin Scale score (aOR, 2.45 [95% CI, 0.80–7.61]).

Conclusions
In our cohort with ICH, RBC transfusions were expectedly given to patients with higher medical and ICH severity. Taking disease severity and timing of transfusions into account, RBC transfusion was not associated with incident hospital complications or poor clinical ICH outcomes.
Sejong's Effects on People's Health: Consequences of a Long Commute
Authors: Lim Seulgi , Lee Soohyung 
Published: May 2023

Abstract
We examine the health impacts of long commute time by exploiting a large-scale placed-based policy in South Korea. The policy relocated public employers in the capital area to disadvantaged cities. However, some public employees kept their residences in the capital area and spend long hours commuting. Using this change, we estimate two-stage least squares models whose results suggest that having a long commute substantially increases usage of medical services, particularly to treat respiratory, circulatory, and endocrine and metabolic diseases. However, we find mixed effects of long commute time on medical checkup outcomes and health-related activities such as exercise.
A Note on City Size and the Sharing of Quasi-Rent between Labor and Capital in China
Authors: Kong Zhe , Zhang Xiaohan , Cui Weiwei 
Published: May 2023

Abstract
We use an asymmetric Nash bargaining model between worker and firms, under the assumption of firm-specific human capital (FSHC), to argue that city size influences the proportion of the rent received by labor (i.e., the magnitude of labor share of rent). We argue that an increase in city size generates both a positive effect (the “FSHC-autonomy effect”) on the bargaining power of labor as well as a negative effect (the division-of-labor effect) on the bargaining power of labor. Our empirical exploration found that labor share of the rent (in percent) increases with city size, suggesting that the FSHC-autonomy effect is greater than the division of labor effect.
Speculative Ephemera: Reimagining Racialized Embodiment in Korean American Family Photographs
Authors: Yim Rachel 
Published: May 2023

Abstract
This article uses personal family photographs to explore a framework of speculative looking. I begin by considering the category of Asian/American woman not as a knowable entity but as an analytic. I then consider family photographs and alternate modes of speculation to further consider Asian/American gendered subject formation. Using photography, I autoethnographically close read images while thinking about the many afterlives of the Korean War in relation to gendered migration, assimilation, and family formation. I argue for a speculative looking that creates new bonds and possibilities for care by insisting on alternate temporal knowledges across time, allowing visibility to become a site of contestation and possibility. Photography has historically functioned to discipline Asian bodies into racialized and gendered subjectivities to monitor citizenship. The ephemerality of family photographs offers a way to think about the nonlinearity of memory and the everyday presence of violence alongside enduring forms of care.
Impact of Teaching Materials Based on the Family Resemblance Approach on Pre-service Chemistry Teachers’ Views of Nature of Science
Authors: Ju Hyunshik , Cho Eun Hye , Paik Seoung-Hey 
Published: May 2023

Abstract
This study investigated the impact of teaching materials developed using the reconceptualized family resemblance approach to the nature of science (RFN) on pre-service chemistry teachers views about the nature of science (NOS). The materials were based on the book Leviathan and the Air-Pump: Hobbes, Boyle, and the Experimental Life by Shapin and Schaffer (1985), which covers various aspects of NOS emphasized by the RFN. The pre-service teachers underwent 15 weeks of constructivist learning, including lectures, discussions, and essay writing, and their understanding of NOS was evaluated using a pre- and post-test. The results revealed changes in their understanding of NOS, particularly in the social aspects of science. This study is significant in shedding light on the specific challenges that participants encountered when grappling with the idea of science as a social and institutional system.