bluuebunny/crossref_metadata_2025_split huggingface dataset:
การเปลี่ยนแปลงความหลากหลายของไมโครไบโอต้าในลำไส้หลังการปลูกถ่ายเซลล์ต้นกำเนิดโดยใช้เซลล์ของผู้อื่น
Authors:   , เกียรติสุรนนท์ พิมพ์กมล 
Published: April 2023

ที่มาและความสำคัญ การเปลี่ยนแปลงของไมโครไบโอต้าในลำไส้ส่งผลกระทบต่อผลลัพธ์และการเกิดภาวะแทรกซ้อนในการปลูกถ่ายเซลล์ต้นกำเนิดโดยใช้เซลล์ของผู้อื่น ปัจจุบันหลักฐานดังกล่าวมีจำกัดในแถบเอเชียและยังไม่เคยมีการศึกษาในประเทศมาก่อน ผู้วิจัยจึงทำการศึกษารูปแบบการเปลี่ยนแปลงของไมโครไบโอต้าในลำไส้และความสัมพันธ์ต่อการเกิดภาวะแทรกซ้อนหลังการปลูกถ่ายเซลล์ต้นกำเนิดโดยใช้เซลล์ของผู้อื่นในประชากรไทย

วิธีการวิจัย ทำการวิจัยแบบนำร่องในผู้ป่วยอายุ ≥ 15 ปีที่เข้ารับการปลูกถ่ายเซลล์ต้นกำเนิดโดยใช้เซลล์ของผู้อื่นในโรงพยาบาลจุฬาลงกรณ์ เก็บตัวอย่างอุจจาระที่ 3 ระยะคือ ภายใน 1 สัปดาห์ก่อนได้รับยาเคมีบำบัดเพื่อรับการปลูกถ่ายเซลล์ต้นกำเนิด ภายใน 3 วันหลังร่างกายยอมรับเซลล์ต้นกำเนิดจากผู้บริจาค (engraftment) และหลังจาก engraftment แล้ว 1 เดือน นำตัวอย่างอุจจาระไปทำการวิเคราะห์ทางจุลชีวิทยาโดย 16S rRNA gene sequencing ประเมินความหลากหลายโดยใช้ Shannon diversity index เพื่อดูการเปลี่ยนแปลงของไมโครไบโอต้าในลำไส้หลังการปลูกถ่ายเซลล์ต้นกำเนิดและดูความสัมพันธ์ระหว่างไมโครไบโอต้าในลำไส้กับการเกิดภาวะเซลล์ต้นกำเนิดใหม่ต่อต้านต้านร่างกายชนิดเฉียบพลัน (acute graft versus host disease, acute GVHD)

ผลการศึกษา ผู้ป่วยที่เข้ารับการปลูกถ่ายเซลล์ต้นกำเนิดโดยใช้เซลล์ของผู้อื่นทั้งหมด 11 ราย มีผู้ป่วย 2 ราย (ร้อยละ 18.2) เกิด acute GVHD ไม่มีผู้ป่วยเสียชีวิตในระหว่าง การศึกษานี้ พบการติดเชื้อในกระแสเลือดและการติดเชื้อ C. difficile อย่างละ 3 ราย คิดเป็นร้อยละ 27.3 จากผลการศึกษา Shannon diversity index ลดลงอย่างมีนัยสำคัญทางสถิติในกลุ่ม post-conditioning regimen เมื่อเทียบกับกลุ่มอื่นๆ แสดงว่าช่วงที่มี engraftment จะมีความมากชนิดและความหลากหลายของแบคทีเรียลดลง

สรุปผล พบการเปลี่ยนแปลงความหลากหลายของไมโครไบโอต้าในลำไส้หลังการปลูกถ่ายเซลล์ต้นกำเนิดโดยใช้เซลล์ของผู้อื่น ความหลากหลายที่ลดลงมีแนวโน้มสัมพันธ์กับการเกิดภาวะแทรกซ้อนคือการติดเชื้อและ acute GVHD สิ่งเหล่านี้บ่งชี้ว่าไมโครไบโอต้าในลำไส้นั้นอาจจะเป็นปัจจัยสำคัญที่มีผลต่อความสำเร็จหรือล้มเหลวในการดูแลรักษาผู้ป่วยที่เข้ารับการปลูกถ่ายเซลล์ต้นกำเนิดโดยใช้เซลล์ของผู้อื่นได้
A corpus-driven study of the English present perfect in general and textbook corpora
Authors:   , Chareonkul Chanakarn 
Published: April 2023

Corpus linguistic research has consistently shown that there is an interconnectedness between patterns and meanings in language use (Hunston and Francis, 2000; Römer, 2006). With regard to the present perfect, little attention has been paid to the relationship between verb patterns and meanings expressed through the tense. This may be one of the reasons why second language learners frequently encounter difficulties in mastering the English present perfect. As Yoshimura et al. (2014) argue, language learners are likely to have a problem with the form/pattern-meaning mapping in the use of the present perfect. To fill this gap, the present study takes a corpus-driven approach to the pattern-meaning relationship of the present perfect through an investigation into British and American English general corpora. It is found that there are seven meanings of the present perfect, namely ‘accomplishment with relevance to the present’, ‘continuing from the past to the present’, ‘change of condition’, ‘experience’, ‘recency’, ‘discovery’, and ‘possession’. These meanings are found to be associated with specific distinctive patterns. The corpus-informed insights were then applied to an analysis of textbooks used in Thailand’s universities. This relationship between patterns and meanings can also be found in the sampled textbooks, but with different ratios. That is, the groups ‘continuing from the past to the present’ and ‘experience’ are found to occur significantly frequently in the sampled textbooks while such a core group as ‘accomplishment with relevance to the present’ shows a significantly lower frequency than that in the general corpora. The study offers a new light on the description of English present perfect and also provides empirical evidence to EFL pedagogical concerns in the development of textbooks and teaching materials.
The development of a learning-oriented reading assessment model to improve English reading ability and promote learning engagement on EFL undergraduate students
Authors:   , Viengsang Raveewan 
Published: April 2023

The study was conducted 1) to examine the effects of the learning-oriented reading assessment model on EFL undergraduate students’ reading ability, 2) to investigate the effects of the learning-oriented reading assessment model on EFL undergraduate students’ reading processes, and 3) to explore the effects of the learning-oriented reading assessment model on EFL undergraduate students’ learning engagement. A mixed-method research design was employed. The study participants were 25 first-year undergraduate students at a public university who were enrolled in a foundation English course. The period of the study was 16 weeks. There were five data collection instruments including the CU-TEP, the end-of-the-unit tests, the learners’ journal, the teacher’s observation notes, and the semi-structured interview protocol. Quantitative data were analyzed using means, standard deviations, percentages, and dependent t-tests, and qualitative data were analyzed by content analysis.

The study findings revealed that the learning-oriented reading assessment model had an effect on the development of students’ reading ability, activated students’ reading processes, and fostered students’ learning engagement. The findings of the study supported the integration of the learning-oriented reading assessment model into an English reading classroom to promote not only language skills such as reading but also an affective factor such as learning engagement of learners.
The stains of various lipsticks on maxillary anterior ceramic veneers
Authors:   , Chotipanvidhayakul Ratirat 
Published: April 2023

This clinical study aims to determine differences in lipstick stains between ceramic veneers and natural teeth. Types of lipsticks affected lipstick stains on ceramic veneers and natural teeth were also investigated. A total of 30 patients were divided into two groups: ceramic-veneer (CV) group and natural-teeth (NT) group with 15 patients in each group. Seven lipstick types: Gloss & Balm, Gloss & Sheer, Cream, Liquid matte, Matte & Frost, Satin, and Matte were applied on patients’ lips. Six labial surfaces of maxillary anterior teeth were evaluated for the frequency of lipstick staining with each type of lipstick. Thus, 90 maxillary anterior teeth were examined per group. Data were analyzed using one-way repeated measures ANOVA (α = .05). One-way repeated measures ANOVA revealed that types of lipsticks had a statistically significant effect on lipstick stains (P < .001). Gloss & Balm lipstick left the highest frequency of lipstick staining in both CV and NT groups. Matte lipstick had the lowest frequency of lipstick staining. However, there was no statistically significant difference between the two groups concerning the lipstick staining (P = .083). In conclusion, based on our findings, types of lipstick affected lipstick stains in both groups. Regarding substrates, there was no statistically significant difference between the two groups.
Fusulinacean biostratigraphy and carbonate petrography of Khao Khwang and Khao Khad formations, Saraburi province
Authors:   , Sirot Sutharat 
Published: April 2023

These research purposes are to study petrography, fusulinids assemblage and age and study biostratigraphy correlation of Khao Khwang and Khao Khad Formations, Saraburi province.

The fusulinids from the study area belong to 5 families, 11 subfamilies, 15 genera and 15 species including Robustoschwagerina, Yangchienia, Parafusulina loeyensis, Parafusulina gigantea, Laosella edoensis, Pseudofusulina, Chusenella chihsiaensis, Chusenella (Chusenella) shengi, Verbeekina verbeeki, Misellina, Pseudodoliolina, Thailandina buravasi, Neoschwagerina megasphaerica, Colania douvillei, Lepidolina shiraiwensis, Presumatrina ciryi, Sumatrina annae and Sumatrina cf. longissima. These fusulinids indicated that Khao Khad Formation was deposited oldest in Sakmarian to Yakhtashian and youngest in Midian age and Khao Khwang Formation was deposited oldest in Murgabian and youngest in Midian age. The petrographic study indicates that the carbonate rocks of the study area could be classified to calcimudstone, bioclastic wackestones, bioclastic floatstone, bioclastic packstone, bioclastic rudstone and microbial boundstone. The depositional environments of these carbonate rocks were varied from tidal, shelf and slope deposit.

The Khao Khwang and Khao Khad Formations correlation indicated that these formations were deposited in different localities in the same age at least in Early Middle Permian to Late Middle Permian (Murgabian to Midian).
Analysis of chewing efficiency in dementia patients using two-color chewing gum test and the viewgum software
Authors:   , Thangjittiporn Chawisa 
Published: April 2023

The purpose of this study was to analyze the relationship between chewing efficacy and severity level of cognitive impairment in dementia patients using a smartphone with ViewGum software for chewing efficiency analysis. Participants (n=70) from the Dementia Clinic, King Chulalongkorn Memorial Hospital, included 38 dementia patients (76.1±9.0 years) and 32 patients (71.8±9.9Years) with mild cognitive impairment (MCI), diagnosed by the medical specialists. The cognitive impairment was assessed by the TMSE (Thai Mental State Examination), and then scored. Participants were assessed for chewing efficacy using the mixing ability test of the two-color chewing gum, followed by an analysis using the ViewGum software. The data analysis revealed the variance of hue (VOH) as the measure of the two-color mixture. Inadequate mixing of the two colors presents with VOH larger than the complete mixture. The images of mixing colors in the gum were taken by the smartphone, and then compared to the scanner by intraclass correlation coefficients (ICCs). The analysis demonstrated ICCs of 0.97 indicating the excellent reliability (0.96; p<0.001;95%CI 0.955-0.982) of the two methods. The chewing efficacy, analyzed from the images taken by the smartphone (P=0.01) and the scanner (P=0.02), of dementia patients was significantly different from patients with MCI shown by Independent t-test analysis. The simple linear regression analysis revealed a significant association between VOH and TMSE score analyzed from the images taken by the smartphone (F(1,53)=6.566, P=0.013, R2= 0.110), and the scanner (F(1,53)=6.437, P=0.014, R2=0.108). This study suggested that the chewing efficacy can be simply analyzed with the two-color chewing gum test and a smartphone image capture for ViewGum software analysis. Within the limitation of this study, the participants demonstrated a significant association between chewing efficacy and the severity level of cognitive impairment. Further studies are necessary to determine whether chewing efficacy can support a prediction of the cognitive impairment in patients with early signs of dementia.
Comparative gene expression analysis of human dental pulp cells from maxillary and mandibular teeth
Authors:   , Faruangsaeng Thira 
Published: April 2023

Objective : Given the anatomical and locational differences between the maxillary and mandibular teeth, it is possible that there are differences in gene expression patterns of dental pulp cells within those teeth. This study evaluates and compares the gene expression profiles of the maxillary and mandibular human teeth with the aim of finding differences in gene expression patterns of dental pulp cells by RNA-Sequencing technique.
Methods : The upper and lower premolar and molar teeth obtained from the same participant were employed. Two pairs of opposing premolar teeth and two pairs of opposing molar teeth were isolated, cultured, and subjected for RNA sequencing. RNA-Seq Alignment and RNA-Seq Differential Expression were used to analyze gene expression profile. Quantitative RT-PCR was performed to confirm the result obtained from RNA-Sequencing.
Results : RNA sequencing demonstrated that 19,372 genes out of 27,914 in total were expressed. The top expression genes were FN1, COL1A1, COL1A2, ACTB and EEF1A1. In DPSCs of posterior teeth (premolar and molar), only PITX1 gene had a significant higher expression (exhibiting 26.47 or 89-fold change) in the lower teeth compared to the upper teeth (64-fold change in premolar teeth and 116-fold change in molar teeth).
Conclusion : We showed that PITX1 gene had a significant higher expression in the lower teeth compared to the upper teeth and this difference in PITX1 level was more evident in the molars compared to premolars.
Effect of trehalose solution spray on post-radiation xerostomia related quality of life in head and neck cancer patients
Authors:   , Pravinvongvuthi Kulpriya 
Published: April 2023

Radiotherapy is the standard treatment of head and neck cancer (HNC). The radiation may affect on normal tissue and surrounding salivary gland resulting to xerostomia. Treatment of radiation-related xerostomia focuses on relieving symptoms by using saliva substitutes or saliva stimulants. Because the salivary stimulants have significant side effects, such as sweating, dizziness or increasing urge to urinate, saliva substitutes are preferable. Trehalose solution has been suggested for improve moisture in dry mouth condition and can be used as saliva substitute. The purpose of this study is to evaluate the effectiveness of 10% Trehalose solution spray to improve dry mouth condition and quality of life (QoL) in post-radiotherapy HNC patients compared with carboxymethylcellulose (CMC) solution spray, which is commonly prescribed for dry mouth patients. Seventy post-radiotherapy patients diagnosed with HNC were included and randomly divided into two groups; to use CMC or Trehalose solution spray. Patients were interviewed with a Xerostomia-related Quality of Life scale (XeQoLs) questionnaire, and then instructed to use spray for two pumps (approximately 0.4 ml.), 4 times a day, after 3 meals and before bedtime. After 14 days of use, all participants were interviewed with the questionnaire again. Saliva was collected before and after use interventions 14 days for measurement of saliva volume and salivary pH. Patients significantly had better XeQoLs scores after use of either CMC or Trehalose solution spray in the aspect of physical, pain/discomfort, and psychological dimensions (P<0.05) but not social dimension (P>0.05). When compared between CMC and Treholose solution spray, the before-after intervention differences of XeQoLs scores were not significantly different (P>0.05). Salivary pH and saliva volume were significantly increased after use Trehalose solution spray (P<0.05), but not statistically significant increased after use CMC solution spray (P>0.05). In conclusion, Trehalose solution spray can effectively relieve post-radiation xerostomia leading to improve QoL of HNC patients comparable with CMC solution spray.
MicroRNA profiles associated with bone healing of the extraction socket in bisphosphonate related osteonecrosis of the jaw in rat model
Authors:   , Surajkulwatana Thapakorn 
Published: April 2023

Bisphoshonates (BPs) are widely used for treating osteoporosis, multiple myeloma, breast cancer, and bone metastasis cancer. Trauma or tooth extraction in patients treated with BPs can lead to MRONJ development because of its mechanism of action by which interferes bone homeostasis and angiogenesis. Once MRONJ has occurred, this hard-to-cure disease posed the risk of having poor quality of life to the patients. The application of miRNA for curing the diseases is now being of interest in medical field. Aiming at elucidating the role of miRNAs in the pathogenesis of MRONJ, a rat model was used in creating MRONJ and the expression of candidate miRNAs was evaluated in this study. Seventeen rats were randomly divided into 2 groups; 1) zolendronate plus dexamethasone-treated group (Zol) and 2) control group which receiving normal saline solution (NSS). Tooth extraction was performed after 2 weeks of BPs administration. The MRONJ occurred in extraction sockets were confirmed by clinical appearances, micro-CT, and histological analysis at Day 28 post-extraction. Bone samples from extraction sites were collected for miRNA analysis. In this study, MRONJ in rat model was successfully established in Zol group. Candidate miRNAs were found to be involving in the development of MRONJ. miRNAs that affected an inhibition of osteoblast maturation, including miR-23a-3p, miR-23b-3p, miR27a-3p and miR-24-3p were upregulated in MRONJ bone tissue samples. Promote-angiogenesis-relating miRNAs such as miR-663a and miR-720 were down regulation in the MRONJ extraction sockets. The expression of miR-34 that had dual effects on both bone remodeling and blood vessel formation was upregulated. This study suggested that the certain miRNAs have a role in controlling the cellular functions related to bone remodeling mechanisms and angiogenic activity in MRONJ.
PVDF hollow fiber membrane modification for dye wastewater treatment by ozonation membrane contacting process
Authors:   , My Hanh 
Published: April 2023

One of the main pollutions from textile wastewater is the dyeing wastewater containing color and organic matters. Among the treatment methods of dye wastewater, ozonation membrane contactor was used as the concept of this research. PVDF membranes were developed by pulse inductively coupled plasma (PICP) and grafted by organosilanes for hydrophobicity enhancement applied for dye wastewater treatment by ozonation membrane contactor. To obtain a stable grafting, the surface of PVDF hollow fiber membrane was activated by the plasma operating condition including two different plasma gases (oxygen and argon), applied voltage and pressure, plasma treatment shot, followed by grafting with four different organosilanes (methyltrichlorosilane (MTCS), trimethylchlorosilane (TMCS),1H,1H,2H,2H-perfluorodecyltriethoxysilane (FAS-C8), and 1H, 1H, 2H, 2H-perfluorooctyltriethoxysilane (FAS-C6), organosilane concentration and different grafting time. The results found that oxygen plasma activation of PVDF membrane was more effective compared to argon plasma. The hydrophobic membrane modified by MTCS and FAS-C8 was increased, while the plasma-activated membranes grafted by TMCS and FAS-C6 did not change. The success of membrane modification was confirmed by the presence of silicon functional group and composition in FTIR and EDX results and the decrease of surface roughness. After activated by oxygen plasma under 10kV/0.3 mbar/2 shots followed by grafting with MTCS for 4h and FAS-C8 for 6h, the water contact angle was greatly increased from 74.7o to 125.3o and 112.7.4o, respectively. The ozone flux of modified membranes was higher and more stable than that of the original PVDF membrane. In addition, PVDF-FAS-C8 membrane gave the highest results in terms of ozone flux and dye removal. Direct Blue 71 (DB 71) and Reactive Red 239 (RR 239) decolorization by PVDF-FAS-C8 membrane were almost complete decolorization. After 90 mins, the COD removals of DB 71 and RR 239 by PVDF-FAS-C8 were 62.5% and 67.5%, respectively. The energy consumption of modified membrane in membrane contactor for dye wastewater was lower than that of original membrane. This study demonstrated that the modified membrane has a potential interest in improving hydrophobicity and membrane contactor applications.
A study of customers’ willingness to purchase organic fresh milk in Thailand
Authors:   , Punwaree Jeerawan 
Published: April 2023

Nowadays, most consumers often are care about health due to the COVID-19 and personal needs. Dairy products are specific products that are generally consumed by every age group, from children, teenagers, adults, to the elderly. Organic milk could provide an advantageous alternative for health conscious consumers as it must be certified by government agencies prior to market launching. There are many studies supported that organic milk is more beneficial than conventional milk. Theory of Planned Behavior (TPB) was applied to study the factors affected consumers' willingness to purchase organic fresh milk in Thailand. Through the questionnaire method and analysis by using the Partial Least Square Structural Equation Modelling, the result collected from 418 consumers reveals that there are seven significant factors as follows: 1) Attitudes toward behavior significantly affect the willingness to purchase 2) Subjective norms significantly affect the willingness to purchase 3) Information on product labels significantly affects the attitudes toward behavior 4) Ethics and animal welfare affects the attitudes toward behavior 5) COVID affects attitudes towards behavior 6) Social media affects subjective norms and 7) Price of goods affects perceived behavioral control respectively. Moreover, it shows the price of customers' willingness to purchase is varied from THB 12.18 to 21.18 for a 200 c.c. bottle of organic fresh milk.
How Action Learning Supports Leadership Development and Organizational Management? Its Application with Case Studies
Authors: Hafeez Muhammad , Zulfiqar Zahid , Ahmad Sajad 
Published: April 2023

Organizations throughout the globe are grappling with the rising problem of strengthening the skills of their leaders with less time and money. Most leadership development (LD) programmes, on the other hand, are ineffective and costly, with little emphasis on the social, interpersonal and strategic dimensions of leadership. Therefore, the objectives of current study were to explore the qualities and skills of leaders essential for the 21st century competency, how action learning (AL) supports the organizational management (OM) and LD and the case studies from different organizations to provide the evidences that how action learning improves the organizational management. For this purpose, a total of 28 previous published articles were selected after following the inclusion and exclusion criteria. The literature showed that AL provided a great supports towards the development of leadership skills and (OM). This study will provide a meaningful direction towards the application of AL in LD and OM.