bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral neuropathy secondary to a ‘domino’ liver transplant: a case report
Authors: Ball Harriet A. , Stevens James , Gillmore Julian D. 
Published: June 2023

Abstract
Background
Peripheral neuropathy caused by amyloidosis is one of the well-recognised sequelae of mutations in the transthyretin gene (TTR).

Case presentation
We describe a case of peripheral neuropathy in a White British 74 year old man with wild-type TTR, 8 years following receipt of a ‘domino’ liver transplant (from a donor with a TTR mutation). The clinical phenotype and neurophysiology, coupled with presence of ATTR amyloid deposits on fat biopsy, established the diagnosis of ATTR amyloid neuropathy, as a consequence of receipt of a variant-TTR secreting liver. A nerve biopsy was not clinically appropriate for this patient. Such cases are rare since recipients of such livers are typically restricted to people whose natural lifespan is unlikely to stretch into the anticipated symptomatic period of ATTR amyloidosis. However, novel “gene silencing” therapeutics are now available which can dramatically alter the course of this disorder, by reducing the proportion of abnormal proteins.

Conclusions
This represents a rare but predictable iatrogenic side effect, and doctors should be aware of this eventuality occurring in a shorter time span than previously anticipated.
“I wanted to hide but also to be found”: the high school experiences of young adults who grew up in the same home as a sibling with depression
Authors: Levkovich Inbar , Labes Michal 
Published: June 2023

Abstract
Background
Depression is a mental health condition that can have far-reaching consequences for the entire family, not just for the affected individual. Siblings are particularly vulnerable in that the unremitting stress and guilt at home can affect multiple aspects of their lives, including relationships, added responsibilities, and health. This pressure may affect siblings’ own emotional well-being and academic success. Most studies in this field have examined the impact of depression on the affected adolescents or their parents, whereas few have examined the impact on siblings. Sibling studies have been limited by lack of sample homogeneity, especially in the context of coping in high school. This study sought to examine the retrospective experiences of young adults who lived in the same house as a sibling with depression while they were in high school.

Methods
This qualitative study examined 21 young adults (aged 18–29) who grew up with a sibling with depression. In-depth, semi-structured interviews were conducted from May to September 2022. The interviews were recorded and transcribed and underwent thematic analysis.

Results
Three main themes emerged from the interviews: (1) “School as a place of refuge”: The perspective of participants who grew up with a sibling with depression regarding their high school experience. (2) “I wanted the adults at school to see me”: Relations between research participants and the school educational staff. (3) “I was afraid people would relate to me as the sibling of a crazy person”: Participants’ relationships with their peers.

Conclusions
This study sheds light on the experiences of adolescents who grew up with a sibling with depression. The findings point to feelings of being invisible, self-nullification, avoiding sharing with others, and transparency. The participants were afraid that if their peers found out about their sibling they would also be stigmatized and alienated. The study shows that adolescents living with a sibling with depression need support at school.
A new insomnia treatment service: the benefits and challenges of establishing a trainee-led service
Authors: Waterman Lauren Z. , Creed Michael 
Published: June 2023

SummaryChronic insomnia is undertreated in the UK despite being a common mental disorder that severely affects quality of life. The lead author, a psychiatry trainee, implemented a new group cognitive–behavioural therapy for insomnia (CBT-I) service for secondary care patients in London with chronic insomnia and comorbid mental illness. Expertise was propagated by trainees teaching other trainees. Nine patients completed all sessions, all with moderate-to-severe insomnia on the Insomnia Severity Index (ISI) at baseline assessment (mean score 21.6). All patients seen at follow-up had improved, scoring in the ‘subthreshold’ or ‘no clinically significant insomnia’ ranges on the ISI (mean 6.6), and all with improvements in comorbid psychiatric symptoms and functioning. This evaluation demonstrates that group CBT-I can be easily learned and delivered by those without formal CBT or sleep medicine training. This could increase the availability and accessibility of treatment. However, bureaucratic challenges were faced, and trainee-led innovations should be better facilitated.
Homelessness and associated factors over a 13-year period among psychiatric in-patients in Berlin, Germany: routine data analysis
Authors: Jalilzadeh Masah Dario , Schouler-Ocak Meryam , Gutwinski Stefan , Gehrenbeck Kirsten , Deutscher Karl , Schindel Daniel , Lech Sonia , Schreiter Stefanie 
Published: June 2023

Background
Homeless patients in psychiatric hospitals are a scarcely studied and there is lack of knowledge about factors associated with homelessness and in-patient treatment.

Aims
To determine the change over time in the number of homeless psychiatric in-patients and to examine factors associated with homelessness.

Method
Retrospective data analysis of 1205 selected electronic patient files on psychiatric in-patient treatment in a university psychiatric hospital in Berlin, Germany. The rate of patients experiencing homelessness over a 13-year period (2008–2021) and the sociodemographic and clinical factors associated with homelessness are analysed over time.

Results
Our study revealed a 15.1% increase in the rate of homeless psychiatric in-patients over the 13-year period. Of the whole sample, 69.3% people lived in secure private housing, 15.5% were homeless and 15.1% were housed in sociotherapeutic facilities. Homelessness was significantly associated with being male (OR = 1.76 (95% CI 1.12–2.76), born outside of Germany (OR = 2.22, 95% CI 1.47–3.34), lack of out-patient treatment (OR = 5.19, 95% CI 3.35–7.63), psychotic disorders (OR = 2.46, 95% CI 1.16–5.18), reaction to severe stress (OR = 4.19, 95% CI 1.71–10.24), personality disorders (OR = 4.98, 95% CI 1.92–12.91), drug dependency (OR = 3.47, 95% CI 1.5–8.0) and alcohol dependency (OR = 3.57, 95% CI 1.67–7.62).

Conclusions
The psychiatric care system is facing an increasing number of patients in precarious social situations. This should be considered in resource allocation planning in healthcare. Individual solutions for aftercare, along with supported housing, could counteract this trend.
Analysis of the Pediatric Radiotherapy Landscape in Mexico and a Subsequent Educational e-Contouring Intervention
Authors: Mailhot Vega Raymond B. , Garcia Robles Beatriz E. , Morris Christopher G. , Buss Kara , Mejia Ulises , Poitevin Adela , Chilaca Rosas Maria Fatima , Perez Villanueva Heynar , Felix Leyva Jesus Armando , Indelicato Daniel J. , De la Mata Dolores 
Published: June 2023

PURPOSE Mexico and Central America have the highest childhood cancer incidence in the West. Pediatric-specific oncology knowledge contributes to the disparity. We sought to (1) determine the self-identified treatment patterns and needs of Mexican pediatric radiation oncologists and (2) pilot a workshop to improve contouring accuracy. MATERIALS AND METHODS Partnering with local experts and the Sociedad Mexicana de Radioterapeutas (SOMERA), a 35-question survey was designed to ascertain pediatric radiotherapy capacity and distributed through the SOMERA listserv. The most challenging malignancies were selected for workshop. Participants received precontouring and postcontouring homework to assess improvement per the Dice metric. The Wilcoxon sign-rank test was used for comparative statistics. RESULTS Ninety-four radiation oncologists attempted and 79 completed the survey. Forty-four (76%) felt comfortable treating a pediatric patient, and 36 (62%) were familiar with national protocols for pediatric treatment. Most had access to nutrition, rehabilitation, endocrinology, and anesthesia; 14% had access to fertility services and 27% to neurocognitive support; 11% noted no support, and only one respondent had child-life support. The postsurvey contouring workshop was conducted for high-grade glioma, medulloblastoma, and Hodgkin lymphoma. Significant improvements were seen in all target volumes. CONCLUSION We present the first national survey of Mexico's pediatric radiotherapy capacity and Latin American e-contouring educational intervention with preworkshop and postworkshop Dice metrics, noting statistically significant improvement in all target volumes. Participation improved compared with prior experience through SOMERA partnership and Continuing Medical Education incentivization.
DIREITOS HUMANOS DOS REFUGIADOS: A VIOLÊNCIA CONTRA O HOMO SACER À LUZ DA CORTE INTERAMERICANA DE DIREITOS HUMANOS / HUMAN RIGHTS OF REFUGEES: VIOLENCE AGAINST HOMO SACER IN THE LIGHT OF THE INTER-AMERICAN COURT OF HUMAN RIGHTS
Authors: Santana Agatha Gonçalves , Amin Aleph Hassan Costa , Dos Santos Caroline Coelho 
Published: June 2023

Resumo: O presente trabalho aborda a temática da desumanização dos direitos humanos dos refugiados que se encontram em situação de extrema vulnerabilidade diante do cenário de violações em que estão inseridos. Tem como problemática entender de que forma os atos de violência perpetrados contra os refugiados contribuem à desumanização dos direitos das pessoas em situação de deslocamento. Como metodologia, analisa-se os direitos dos refugiados através dos dispositivos internacionais de proteção de direitos humanos, bem como de julgados da Corte Interamericana de Direitos Humanos (Corte IDH) referentes à violação dos direitos desses indivíduos. O método utilizado foi o hipotético-dedutivo, através de pesquisa bibliográfica e documental, com ênfase na técnica de pesquisa de análise na legislação internacional dos direitos humanos dos refugiados. Conclui-se que este fenômeno é instaurado mediante análise da definição do termo homo sacer e da violação ao princípio do non refoulement decorrente da intolerância dos Estados receptores de emigrados.Palavras-chave: Direitos humanos; Refugiados; Violência; Homo sacer; Corte Interamericana de Direitos Humanos. Abstract: The present work addresses the issue of dehumanization of the human rights of refugees who are in a situation of extreme vulnerability in the face of the scenario of violations in which they are inserted. It is problematic to understand how the acts of violence perpetrated against refugees contribute to the dehumanization of the rights of people in situations of displacement. As a methodology, the rights of refugees are analyzed through international provisions for the protection of human rights, as well as judgments of the Inter-American Court of Human Rights (IHR Court) regarding the violation of the rights of these individuals. The method used was the hypothetical-deductive, through bibliographic and documentary research, with emphasis on the research technique of analysis in the international legislation of the human rights of refugees. It is concluded that this phenomenon is established by analyzing the definition of the term homo sacer and the violation of the principle of non-refoulement resulting from the intolerance of the receiving States of emigrants.Keywords: Human rights; Refugees; Violence; Homo sacer; Inter-American Court of Human Rights.
COLABORAÇÃO PREMIADA: INSPIRAÇÃO E COMPATIBILIZAÇÃO COM O ORDENAMENTO JURÍDICO BRASILEIRO / AWARD-WINNING COLLABORATION: INSPIRATION AND COMPATIBILITY WITH THE BRAZILIAN LEGAL SYSTEM
Authors: Afonso Paulo Adaias Carvalho , Pereira Ricardo Souza , Lofrano José Renato Hojas 
Published: June 2023

Resumo: Desde a superação da vingança privada, com o Estado monopolizando a jurisdição criminal, tornou-se essencial compreender o processo penal como uma garantia individual contra abusos. Neste ponto, a Constituição de 1988 representou considerável avanço. Por outro lado, com avanço da criminalidade organizada, o legislador começou a buscar meio de estimular delinquentes a contribuir com a persecução penal, demonstrando a necessidade premente de utilização de elementos da justiça criminal negocial criminal no cotidiano forense brasileiro, em especial a colaboração premiada. De forte inspiração no common law, a colaboração premiada é uma espécie da justiça criminal negocial (gênero) inserida no ordenamento jurídico brasileiro e, como tal, deve receber adequação para compatibilização com o sistema jurídico brasileiro. O trabalho se propõe a identificar formas de compatibilização de instituto tão amplo aos direitos e garantias constitucionais do Brasil. Para elaboração do presente trabalho, adotou-se como metodologia a pesquisa bibliográfica, em especial sobre artigos científicos, livros, jurisprudência e legislação interna, com abordagem empírica do ingresso da Lei n.º 12.850/13 e a evolução jurisprudencial.Palavras-chave: Direitos fundamentais; Colaboração premiada; Lei de organização criminosa; Dinamogenesis; Justiça criminal negocial. Abstract: Since the overcoming of private revenge, with the State monopolizing criminal jurisdiction, it has become essential to understand the criminal process as an individual guarantee against abuse. At this point, the 1988 Constitution represented a considerable advance. On the other hand, with the advancement of organized crime, the legislator began to look for ways to encourage offenders to contribute to criminal prosecution, demonstrating the pressing need to use elements of criminal business criminal justice in the Brazilian forensic routine, in particular the award-winning collaboration. Strongly inspired by the common law, the award-winning collaboration is a kind of business criminal justice (gender) inserted in the Brazilian legal system and, as such, should be adapted to make it compatible with the Brazilian legal system. The work aims to identify ways of making such a broad institute compatible with Brazil's constitutional rights and guarantees. For the preparation of this work, bibliographic research was adopted as a methodology, especially on scientific articles, books, jurisprudence and internal legislation, with an empirical approach to the enactment of Law No. 12,850/13 and the jurisprudential evolutionKeywords: Fundamental rights; Award-winning collaboration; Criminal organization law; Dynamogenesis; Business criminal justice.
Max's legacy: an evaluation of the impacts of baby loss on staff and families
Authors: Whitehouse Claire , Crane Racheal , Rostron Heather , Cater Kirsty 
Published: June 2023

Background/Aims There is a paucity of literature on the impact of baby loss experiences on family and staff. This study aimed to explore existing support available to families and staff in a UK hospital for first trimester miscarriage, as well as experiences of baby loss, and make recommendations for future care. Methods A mixed-methods service evaluation was conducted. Data were gathered from healthcare professionals (surveys, phase 1; interviews, phase 2) and service users who had experienced baby loss (focus group discussions, phase 3). Qualitative data were analysed thematically, alongside descriptive quantitative results. Results Communication, support, recognition of loss and environment were key contributors to positive and negative experiences for staff and families. Peer support enhanced communication, reduced isolation and increased ability to function on a daily basis following loss. Conclusions Formal, resourced maternity bereavement aftercare services are essential to the support the experiences, outcomes and safety of staff and families experiencing baby loss and miscarriage.
Women's experiences accessing continuity of care in Ireland: a qualitative study
Authors: Hunter Andrew , Lennon Roisin A , Biesty Linda 
Published: June 2023

Background/Aims In January 2017, a continuity of care advanced midwife practitioner service was introduced in an Irish maternity unit. Continuity is central to high-quality maternity care, but little is known about it at an advanced practice level or about women's experiences of this model of caregiving. This study's aim was to provide insight into the experiences of women accessing a continuity of care service in Ireland. Methods A qualitative descriptive design and thematic analysis was used. A total of 11 women, who attended the advanced midwifery practitioner service and had experienced a different model of care in a previous pregnancy, were interviewed. Results Two themes were identified. Positive comparison to previous care, which had three subthemes, and access to the advanced midwifery practitioner, with four subthemes. Conclusions Continuity from an approachable and competent practitioner with time for discussion and unscheduled access to the service was rated highly. Participants wanted to ‘future proof’ the service and recommended that continuity of care needs to be available to all pregnant women and at the forefront of service development.
Review of the national usage of antibiotics in arthroplasty surgery: a need for evidence-based prescribing
Authors: Hassanzadeh H , Ferro A , Woods K , Baring T 
Published: June 2023

Introduction Surgical site infections (SSI) remain one of the most serious complications of arthroplasty surgery. The role of antibiotic prophylaxis in preventing SSI post-arthroplasty is well established. However, there is considerable heterogeneity in prophylactic prescribing across the United Kingdom (UK), which is contradicted by the contemporaneous evidence. This descriptive study aimed to compare the current first-line antibiotic recommendations across hospitals in the UK and The Republic of Ireland for elective arthroplasty procedures. Methods The MicroGuide mobile phone application was used to access hospital antibiotic guidelines. First-line antibiotic recommendation and dosing regimen for primary elective arthroplasties were recorded. Findings A total of nine distinct antibiotic regimens were identified through our search. The most frequently used first-line antibiotic was cefuroxime. This was recommended by 30 of the 83 (36.1%) hospitals in the study. This was followed by a combination of flucloxacillin and gentamicin, which was used by 38 of 124 (31%) hospitals. There was also significant heterogeneity in dosing regimens. A single prophylactic dose was most commonly recommended (52%); 4% of hospitals recommended two prophylactic doses, 19% three doses and 23% four doses. Conclusions Single-dose prophylaxis is recognised as at least noninferior to multiple-dose prophylaxis in primary arthroplasty. There is considerable variation in the local antibiotic recommendations for surgical site prophylaxis post-primary arthroplasty surgery, with respect to both recommended first-line antibiotic and dosing regimens. With increasing emphasis on the importance of antibiotic stewardship and the emergence of antibiotic resistance, this study highlights the need for an evidence-based approach to prophylactic dosing across the UK.
A registered report of a crossover study on the effects of face masks on walking adaptability in people with Parkinson’s disease and multiple sclerosis
Authors: Eschweiler Mareike , McCrum Christopher , Giannouli Eleftheria 
Published: June 2023

Background
Face masks protrude into the lower visual field causing reduced perception of visual stimuli, potentially making obstacle avoidance during walking more difficult and increasing fall risk. Recommendations on walking and mask wearing for older adults have been debated, with no clear consensus on the various factors interacting and influencing walking safety while wearing a face mask. It is particularly important to address this issue in populations at an increased risk of falls. Therefore, this study aims to investigate the effects of mask-wearing on objectively measured walking adaptability in people with Parkinson’s disease and Multiple Sclerosis.

Methods
50 patients with either Parkinson’s disease or Multiple Sclerosis attending inpatient neurorehabilitation will be recruited to participate in this crossover study. Performance during a standardized gait adaptability (C-Gait) test on a VR-based treadmill (C-Mill+VR), as well as during clinical mobility tests (10-meter walk test, Timed Up & Go test, and stair ambulation) will be measured with and without an FFP2- mask (order randomized). In addition, participants will be asked about their perceived performance and perceived safety during the tests with and without a mask. Performance on the seven C-Gait subtests is based on centre of pressure-derived measures of foot placement in relation to the different tasks. These are averaged and added to a cognitive C-Gait task to give the overall composite score (primary outcome). Secondary outcomes will include the different subscores and clinical mobility tests.

Potential significance
This study will make an important contribution to an ongoing debate regarding recommendations persons with and without a neurological disease should be given regarding wearing a face mask while walking. Furthermore, the study will complement the existing scientific discourse with clinical data from people with a neurological disease for whom falls, mobility deficits and mask wearing may be more frequent, which can help inform evidence-based recommendations.

Trial registration
German clinical trial register: DRKS00030207.
Predictors of intention to provide abortions after OB/GYN residency training
Authors: Kramer Katherine J. , Ottum Sarah , Chao Conrad R. , Runyan Aliye , Rappolee Benjamin , Sadek Sandra , Jannat Noor E. , Recanati Maurice-Andre 
Published: June 2023

Introduction
Abortion is a common gynecological procedure and plays a central role in women’s health and autonomy. To maintain accessibility to abortion, it is important that sufficient obstetrics and gynecology (Ob/Gyn) residents intend to provide abortion care after residency. This study identifies factors that influence a resident’s intention to provide abortions (IPA) post-training.

Materials and methods
A multiple-choice survey, addressing demographics, religious background, residency program metrics, training experience and intent to provide abortions (IPA), was answered by 409 Ob/Gyn residents. Chi-square test was performed on descriptive statistics and continuous variables were tested with ANOVA with p<0.05 considered significant.

Results
Residents with IPA were predominantly female (p = 0.001), training in the Northeast and West (p<0.001), identifying either as non-religious, agnostic/atheist or Jewish (p<0.01), not actively practicing their religion (p<0.001) and leaning democrats (p<0.002). Those with IPA were more likely to train at hospitals without religious affiliation (p<0.008), to train at a Ryan Program (p<0.001), to place strong emphasis on choosing a program with family planning training (p<0.001), to join programs where a significant portion of the faculty performs abortions (p<0.001) and to have completed a higher number of first trimester medical and surgical abortion procedures during the last six months of training (p<0.001).

Conclusion
These results suggest that factors influencing a physician’s intention to provide abortions are multifactorial, involving personal and program factors. A model predicting IPA is derived. To maximize IPA, residency programs can increase abortion volume, facilitate additional training and build a supportive faculty.