bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a Multistage Feed-forward Operational Amplifier for High- Speed Continuous-Time ΣΔ ADCs
Authors: Zhang Qizheng , Chang Ke , Pu Yang , Wang Yan , Wang Yuxin , Zhang Guohe 
Published: May 2023

Abstract
This paper presents a high-gain, high-frequency, bandpass operational amplifier with feed-forward compensation. It is designed to meet the requirements of a continuous time (CT) bandpass sigma delta (Σ∆) modulator with multi-GHz sampling frequency. The circuit consists of a main path composed of four stages of transconductance amplifiers and two feed-forward paths, and a common-mode feedback circuit is added to each stage to stabilize the DC operating point. The feed-forward compensation solves the problem that Miller compensation fails at high frequencies. The position of zeros and poles is adjusted by two feed-forward paths to improve the in-band phase margin. Low frequency and in-band noise are suppressed by adjusting the transfer function, and power consumption is reduced by current multiplexing. With a parallel load of 2 pF and 500 Ω, the post netlist simulation shows that this design achieves a gain of more than 45 dB in the bandwidth range of 10 kHz to 400 MHz, a unit gain frequency of 16.48 GHz and a phase margin of 66 ° under the conditions of a 1.2 V supply voltage. The maximum input equivalent noise is 8.97 \({\mu }\text{V}/\sqrt{\text{H}\text{z}}\) with a quiescent power dissipation of 35.3 mW.
Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor
Authors: McCarthy Derrick , Lofgren Michael , Watt Amy , Horton Holly , Kieffer-Kwon Philippe , Ding Jian , Kobold Sebastian , Baeuerle Patrick A. , Hofmeister Robert , Gutierrez Dario A. , Tighe Robert 
Published: May 2023

Abstract
T cells expressing a mesothelin (MSLN)-specific T cell receptor fusion construct (TRuC®), called TC-210, have demonstrated robust antitumor activity in preclinical models of mesothelioma, ovarian cancer, and lung cancer. However, they are susceptible to suppression by the programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PDL1) axis and lack intrinsic costimulatory signaling elements. To enhance the function of anti-MSLN TRuC-T cells, chimeric switch receptors (CSRs) have been designed to co-opt the immunosuppressive PD-1/PD-L1 axis and to deliver a CD28-mediated costimulatory signal. Here, we report that coexpression of the PD1-CD28 CSR in TRuC-T cells enhanced T cell receptor signaling, increased Th1 effector cytokines, decreased Th2/Th17 cytokines, and sustained effector function in the presence of PD-L1 when compared with TC-210. AntiMSLN TRuC-T cells engineered to coexpress PD1-CD28 CSRs comprising the ectodomain of PD-1 and the intracellular domain of CD28 linked by the transmembrane domain of PD-1 were selected for integration into an anti-MSLN TRuC-T cell therapy product called TC-510. In vitro, TC-510 showed significant improvements in persistence and resistance to exhaustion upon chronic stimulation by tumor cells expressing MSLN and PDL1 when compared with TC-210. In vivo, TC-510 showed a superior ability to provide durable protection following tumor rechallenge, versus TC-210. These data demonstrate that integration of a PD1-CD28 CSR into TRuC-T cells improves effector function, resistance to exhaustion, and prolongs persistence. Based on these findings, TC-510 is currently being evaluated in patients with MSLN-expressing solid tumors.
Slow gait speed as a potential indicator for common geriatric syndromes besides sarcopenia
Authors: He Xu , Li Yan , Chen Jun , Zhang Li , Quan Jing , Lu Sunrui , Ying Zhou , Huang Yan , Wang Kehua 
Published: May 2023

Abstract
Background Geriatric syndromes are posing increasing health threat in an aging population. The reliable indicator of geriatric syndromes is of great clinical value for early diagnosis and intervention.
Aims To investigate the potential application of slow gait speed as a signal for identifying common geriatric syndromes besides sarcopenia in the elderly.
Methods A total number of 985 elderly outpatients (457 men and 528 women) were recruited in the study. The subjects were classified into two groups according to the gait speed cut-off (1.0m/s), with the individuals being assigned as normal speed group (NSG) when the gait speed≥1.0m/s and the slow speed group (SSG) was defined as the gait speed <1.0m/s. CGA management system Simply Edition (CGA-SE) software was implemented to collect data, compare the demographic variations and assess the prevalence of functional decline in the two groups.
Results Compared to the NSG, SSG subjects were significantly older, shorter in height, lighter in weight and consumed more medicine. SSG subjects also showed a higher score in Edmonton symptom assessment, Self-Rating Depression Scale (SDS), Self-rating Anxiety Scale (SAS), and Mini Nutritional Assessment (MNA), and had a lower score in Barthel index of Activities of Daily Living (BADL) assessment and Mini-Mental State Examination (MMSE). There was a significantly higher prevalence of frailty, disability, depression, and dementia in SSG when compared to NSG. In addition, gait speed was an independent predictive factor associated with a higher risk of frailty, disability, dementia, and swallowing dysfunction.
Conclusions Slow gait speed could be used as an indicator for several common geriatric syndromes in elderly outpatients. We recommended the 6 meters walk test as a routine examination for the elderly in the geriatric department.
Circulating Epstein‒Barr virus microRNA BART8-3p as a potential biomarker for detection and prognostic prediction in early nasopharyngeal carcinoma
Authors: Lin Cheng , Chen Yuebing , Lin Xiandong , Lin Keyu , Huang Juan , Xiong Jiani , Lin Shaojun , Pan Jianji , Zong Jingfeng , Li Meifang 
Published: May 2023

AbstractBackgroudTo evaluate the clinical significance of plasma Epstein‒Barr virus (EBV) BamHI A rightward transcript (BART)-encoded microRNA 8-3p (miR-BART8-3p) in patients with early nasopharyngeal carcinoma (NPC).MethodsA total of 126 patients with stage I and II NPC were retrospectively analysed. A receiver operating characteristic curve (ROC) was used to examine the diagnostic performance. Kaplan‒Meier analysis was applied to determine survival. Cox regression was used for univariate and multivariate analyses.ResultsThe sensitivity, specificity and area under the curve (AUC) value of plasma miR-BART8-3p alone in the detection of early NPC were 69.0%, 97.2% and 0.826, respectively, and the corresponding rate was up to 88.9%, 94.4% and 0.931 when miR-BART8-3p was combined with EBV DNA. Compared to patients with low expression of miR-BART8-3p, patients with high expression of miR-BART8-3p had significantly shorter overall survival (OS), locoregional recurrence-free survival (LRRFS) and distant metastasis-free survival (DMFS). High-risk patients (with both high miR-BART8-3p and high EBV DNA) had inferior OS, LRRFS and DMFS than low-risk patients (neither high EBV DNA nor high miR-BART8-3p) (P< 0.05). Multivariate analysis verified that the high-risk group was an unfavorable factor for OS (HR = 18.39; 95% CI 1.53-221.69;P= 0.022) and DMFS (HR = 21.06; 95% CI, 2.30-192.75;P= 0.007). A nomogram based on miR-BART8-3p could better predict patients' metastatic probability.ConclusionCirculating miR-BART8-3p is a potential biomarker for detection and prognostic prediction in early NPC. Future clinical trials are needed to confirm and develop personalized and precise strategies for those patients.
Metaheuristic Model of Gene Selection for Deep Learning Early Prediction of Cancer Disease Using Gene Expression Data
Authors: Joshi Amol Avinash , Aziz Rabia Musheer 
Published: May 2023

Abstract
Cancer prediction in the early stage is a topic of major interest in medicine since it allows accurate and efficient actions for successful medical treatments of cancer. Mostly cancer datasets contain various gene expression levels as features with less samples, so firstly there is a need to eliminate similar features to permit faster convergence rate of prediction algorithms. These features (genes) enable us to identify cancer disease, choose the best prescription to prevent cancer and discover deviations amid different techniques. To resolve this problem, proposed a hybrid novel technique CSSMO, based feature selection for cancer prediction. First, combine the use of Spider Monkey Optimization (SMO) along with Cuckoo search (CS) algorithm viz. CSSMO for feature selection, which helps to combine the benefit of both metaheuristic algorithms to discover a subset of genes which helps to predict a cancer disease in early stage. Further, to enhance the accuracy of the CSSMO algorithm, choose a cleaning process, minimum redundancy maximum relevance (mRMR) to lessen the gene expression of cancer datasets. Next, these subsets of genes are classified using Deep Learning (DL) to identify different groups or classes related to a particular cancer disease. Six different datasets have utilized to analyze the performance of the proposed approach in terms of cancer sample classification and prediction with Recall, Precision, F1-Score, and confusion matrix. Proposed gene selection method with DL achieves much better prediction accuracy than other existing Deep Learning (DL) and Machine learning models with a large gene expression datasets.
Mongolian HCC vs. Caucasian HCC: The Metabolic Reprogramming Process in Mongolian HCC is an Interesting Difference
Authors: huang rui , Zhang Zejuan , Ma Wei , Song Lei , Dong Kaizhong , Xie Xiaofeng , Yang Kun , Hai Xiangjun 
Published: May 2023

Abstract
Racial/ethnic and region disparities in incidence and mortality are obviously in liver cancer. Mongolia has the highest reported incidence and mortality of hepatocellular Carcinoma (HCC) in the world, while the incidence of HCC is relatively low in the United States, but differences in their molecular characteristics remain largely elusive. Here we report differentially expressed genes(DEGs) in Mongolian hepatocellular carcinoma and in Caucasian HCC and their intersection DEGs, as well as their corresponding signaling pathways in Mongolian and Caucasian hepatocellular carcinoma patients based on the transcriptome sequences from GEO database. We got 908 up-regulated genes and 1946 down-regulated genes in Mongolian HCC, 1244 up-regulated genes and 1912 down-regulated genes in Caucasian HCC, 254 Co-upregulated genes and 1035 co-downregulated genes in Mongolian and Caucasian. The results of GO enrichment analysis showed that most of the genes with altered expression levels in Mongolian HCC participate in biological processes that involve metabolic reprogramming of various substances, accounting for about one-third of all biological processes. In particular, multiple amino acid biosynthesis and metabolic processes appear to be specific in Mongolian HCC compared with Caucasian HCC. The biological processes they share include those in which most immune cells are involved and cell cycle-related biological processes. In addition, we also found the genes UPP2, PCK1, GLYAT, ASPDH, GNMT, ADH1B and HPD, encode for key metabolic enzymes, whose expression level up-regulated or down-regulated more than 5 times in Mongolian HCC and was dramatically correlated with survival in Mongolian HCC (p value < 0.01), More importantly, these molecules are potential targets for some metabolic antitumor drugs. This result may have important implications for the study of the pathogenic factors and molecular mechanisms of hepatocellular carcinoma and the precise therapy of Mongolian HCC.
Association of IL-23R (rs11209026 A/G) polymorphism with susceptibility to common autoimmune diseases: a meta-analysis combined with trial sequence analysis
Authors: Zhang Xu , Zhang Tao , Xu Siwen , Yu Lingxiang , Ni Jianping , Peng Yongzhen , Chen Xuyang , Wang Guosheng , Sun Wanqi , Pan Faming 
Published: May 2023

Abstract
Autoimmune disease is a condition in which the body responds to the autoantigens and causes damage to its own tissues. We conducted this research to investigate whether interleukin-23R (IL-23R) gene polymorphisms (rs11209026 A/G) are related to the risk of several common autoimmune diseases like rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriasis. We screened articles about rs11209026 A/G for autoimmune disease by China Knowledge Infrastructure Project (CNKI), Web of Science as well as PubMed databases. The correlation strength was expressed by odds ratio (OR) and 95% confidence interval, and the trial sequential analysis (TSA) proved the reliability of the results. Generally, 33 studies were contained. There was a significant correlation between rs11209026 A/G polymorphism and the susceptibility of human autoimmune diseases (OR = 0.78, 95% CI = 0.65–0.94, p < 0.05). In addition, allele A was associated with AS (OR = 0.61, 95% CI = 0.55–0.68, p < 0.05) and psoriasis (OR = 0.51, 95% CI = 0.34–0.77, p < 0.05), but not RA (p > 0.05). In ethnic subgroup analysis, AA genotype could reduce the risk of AS in Caucasian people (OR = 0.46, 95% CI = 0.25–0.87, p < 0.05), and in the results of dominant gene model analysis, AA + GA has statistical significance in reducing the risk of autoimmune diseases (OR = 0.69, 95% CI = 0.56–0.84, p < 0.05). Meta-analysis showed that IL-23R gene polymorphism (rs11209026 A/G) is associated with AS, RA and Psoriasis and allele A is a protective factor, especially in Caucasian population.
The Evaluation of Quantitative Parameters of Dual-layer spectral detector CT for Discrimination of Differentiation grade, T Stage, and Lymph Node Metastasis stage of Colorectal Adenocarcinoma
Authors: Chen Jinghua , Xie Ping , Qian Tingting , Huang Jian , Shi Yiqiu , Shen Yuwen , Xu Chi , Liu Kefu 
Published: May 2023

Abstract
Objectives To investigate the value of quantitative parameters of Dual-layer spectral detector CT (SDCT) in the differentiation grade, T stage, and lymph node metastasis stage of colorectal adenocarcinoma (CRAC).Methods 86 eligible CRAC patients were included in this study. The conventional CT values, 40 keV values, 100 keV values, effective atomic number (Zeff) values, iodine concentration (IC) values, normalized iodine concentration (NIC) and spectral curve slope (λ) during the arterial phase (AP) and venous phase (VP) of CRAC were compared according to the differentiation grade, T stage, and lymph node metastasis stage.Results The measured values of the spectral quantitative parameters of the CRAC were consistent within the observer (ICC range 0.791–0.979). The 100kev-AP, RT-VP, 40keV-VP, 100keV-VP, Zeff-VP, IC-VP, λ-VP had significant differences among different grades of CRAC differentiation (P < 0.05). ROC showed the AUCs were 0.620, 0.673, 0.680, 0.708, 0.672, 0.678, 0.682 for 100kev-AP, RT-VP, 40keV-VP, 100keV-VP, Zeff-VP, IC-VP, λ-VP differentiating the well differentiation from moderately and poorly differentiation. CT parameter values showed no statistical difference between T1-2 and T3-4 stage, as well as among lymph node metastasis stages of CRAC (P > 0.05).Conclusion The quantitative parameters of SDCT had good diagnostic efficacy in differentiating differentiation grades of CRAC, however did not show the value for identifying T stage and lymph node metastasis stage.
The propagation of inhomogeneous waves in an orthotropic viscoelastic medium
Authors: Xuan Tung Do 
Published: May 2023

Abstract
The present paper deals with the propagation of inhomogeneous waves in an orthotropic viscoelastic medium. For chosen directions of propagation and a real finite inhomogeneity parameter, a complex slowness vector is specified to define the propagation of inhomogeneous incident wave. Then the reflection , transmission of plane waves at a plane interface between two orthotropic viscoelastic halfspaces are discussed. In this incidence, horizontal slowness determines the slowness vectors for all reflected, transmitted waves. For each reflected, transmitted wave, the corresponding slowness vector is resolved to define its phase direction, phase velocity and attenuation angle. Appropriate boundary conditions on this wave-field determine the amplitude ratios for reflected, transmitted waves relative to the incident wave. The numerical examples are provided to show the effect of the inhomogeneity of incident wave on the propagation characteristic as well as the reflection and transmission coefficients of the reflected, transmitted waves.
Nanosecond Time-Resolved Infrared Spectroscopy for the Study of Electron Transfer in Photosystem I
Authors: Mäusle Sarah M. , Agarwala Neva , Eichmann Viktor G. , Dau Holger , Nürnberg Dennis J. , Hastings Gary 
Published: May 2023

Abstract
Microsecond time-resolved step-scan FTIR difference spectroscopy was used to study photosystem I (PSI) from Thermosynechococcus vestitus BP-1 (T. vestitus, formerly known as T. elongatus) at 77 K. Photoaccumulated (P700+ – P700) FTIR difference spectra were also obtained for PSI from T. vestitus at both 77 and 293 K. The FTIR difference spectra are presented here for the first time. To greatly extend upon these FTIR studies nanosecond time-resolved infrared difference spectroscopy was also used to study PSI from T. vestitus at 293 K. Nanosecond infrared spectroscopy has never been used to study PSI samples at physiological temperatures, and here it is shown that such an approach has great value as it allows a direct probe of electron transfer down both branches in PSI. In PSI at 293 K, the infrared flash-induced absorption changes indicate electron transfer down the A- and B-branches is characterized by time constants of 33 and 364 ns, respectively, in good agreement with visible spectroscopy studies. These time constants are associated with forward electron transfer from A1– to FX on the B- and A-branches, respectively. At several infrared wavelengths flash-induced absorption changes at 293 K recover in tens to hundreds of milliseconds. The dominant decay phase is characterized by a lifetime of 128 ms. These millisecond changes are assigned to radical pair recombination reactions, with the changes being associated primarily with P700+ rereduction. This conclusion follows from the observation that the millisecond infrared spectrum is very similar to the photoaccumulated (P700+ – P700) FTIR difference spectrum.
Approaching a sustainable vector model for environmental crisis management
Authors: Flori Maria 
Published: May 2023

Abstract
The major challenge facing human society in the 21st century is represented by the environmental crisis. In this context, the present article proposes a sustainable vector model for managing the environmental crisis. It focuses on social, economic, and ecological aspects, with the aim of providing a framework for analysis and adapted solutions. By integrating environmental factors into decision-making processes and public policies, this model aims to improve the quality of life and promote sustainable development. This study presents a comprehensive and cohesive framework for addressing environmental challenges by integrating the Context Triangle and Phenomenon Triangle to develop a sustainable vector model. This novel approach to crisis management aims to provide a holistic and adaptive response to the complex and evolving needs of society and the environment, acknowledging the interconnected nature of environmental issues. The proposed sustainable vector model seeks to understand the trade-offs and synergies between various dimensions of sustainability, ultimately facilitating the development and implementation of more robust and equitable strategies. By incorporating this vector-based approach, the integrated framework can be employed to examine the intricate relationships between different aspects of environmental challenges, fostering a deeper understanding of their interconnected nature and promoting more effective interventions. Moreover, potential advancements may involve fractalizing the integrated framework on multiple levels, allowing for a more elaborate and comprehensive sustainable management approach. By extending the system into a multi-level fractal structure, stakeholders can investigate the relationships between different aspects of environmental challenges, ultimately driving the development of innovative and adaptive strategies that can better address the ever-changing needs of our planet and its inhabitants.
Nanomolar range of FAM237B can activate receptor GPR83
Authors: Li Hao-Zheng , Wang Ya-Fen , Hu Wen-Feng , Liu Ya-Li , Xu Zeng-Guang , Guo Zhan-Yun 
Published: May 2023

Abstract
The orphan G protein-coupled receptor 83 (GPR83) is implicated in the regulation of energy metabolism and certain anxiety-related behaviors. Our recent study confirmed that family with sequence similarity 237 member A (FAM237A), also known as neurosecretory protein GL (NPGL), is an efficient agonist for GPR83, but did not support the proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N, also known as proSAAS)-derived peptide PEN and the procholecystokinin-derived peptide proCCK56-63 as ligands of this receptor. FAM237B (also known as NPGM), a paralog of FAM237A, was previously reported as a weak agonist for GPR83 with approximately 100-fold lower activity in an inositol 1-phosphate accumulation assay. In the present study, we prepared mature human FAM237B via an intein-fusion approach and measured its activity towards human GPR83 via a NanoLuc Binary Technology (NanoBiT)-based ligand‒receptor binding assay and a NanoBiT-based b-arrestin recruitment assay. Mature FAM237B displayed moderately lower activity than its paralog FAM237A in these binding and activation assays, but could cause a significant activation effect at the nanomolar range (1‒10 nM). Thus, FAM237B appears to be another endogenous agonist for receptor GPR83.
Proportional Income Taxation from the Perspective of the Dynamic Model of Life Cycle Theory: brazilians case
Authors: MATOS DANIEL 
Published: May 2023

Abstract
The present research analyzes the possibility of changing the current progressive tax system on income due to its economic inefficiency, and worsening levels of inequality, as well as the historical aim of increasing tax burdens with income tax reforms with the aim of covering extraordinary expenses incurred by the State. Because of this, the core of the research investigates the possibility of applying the life cycle theory to taxation on the income of taxpayers residing in Brazil, suggesting a profound change in the current design of the progressive system of taxation on income for a proportional taxation system. on income that is based on the life cycle theory, consisting of a model that confers efficiency and may eventually be fair depending on the country's situation.
JEL classification H21 . H23 . H29
Title: Anaesthetic Concerns and Management of a Child with Michel’s Aplasia Undergoing Auditory Brainstem Implantation- A Case Report
Authors: Reddy Ashwini , Panda Nidhi , Ghai Babita , Panda Naresh , Kameswaran Mohan , Vasudevan M C 
Published: May 2023

Abstract
Hearing rehabilitation treatment is dictated by the nature and etiology of hearing loss. Patients with absent/destroyed cochlear nerves or complete labyrinthine aplasia (Michel’s aplasia) render peripheral cochlear stimulation ineffective and such patients benefit from an auditory brainstem implant (ABI). A coordinated multidisciplinary team approach is necessary for the safe conduct of this challenging surgery using electrophysiologic measures to confirm the accurate placement of the ABI array. The role of the anaesthesiologist ranges from preoperative assessment of syndromal associations, difficult airway assessment, building rapport with the child, and counseling the family. Adequate premedication, smooth induction, and facilitation of neurophysiological monitoring are essential. The anaesthetist also plays a crucial role in decreasing intracranial pressure and improving surgical access while avoiding excessive cerebellar retraction. Close monitoring of vitals, care of the lumbar drain, provision of adequate analgesia, and antiemesis are the main concerns postoperatively.