bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Anti‐Tumor Effect of Toosendanin and Paclitaxel on Triple‐Negative Breast Cancer via Regulating ADORA2A‐EMT Related Signaling
Authors: Zhang Juan , Xu Hong‐Xi , Wu Yu‐Lin , Cho William Chi Shing , Xian Yan‐Fang , Lin Zhi‐Xiu 
Published: July 2023

AbstractTriple negative breast cancer (TNBC) is an aggressive cancer with very poor prognosis. Combination therapy has proven to be a promising strategy for enhancing TNBC treatment efficacy. Toosendanin (TSN), a plant‐derived triterpenoid, has shown pleiotropic effects against a variety of tumors. Herein, it is evaluated whether TSN can enhance the efficacy of paclitaxel (PTX), a common chemotherapeutic agent, against TNBC. It is found that TSN and PTX synergistically suppress the proliferation of TNBC cell lines such as MDA‐MB‐231 and BT‐549, and the combined treatment also inhibits the colony formation and induces cell apoptosis. Furthermore, this combination shows more marked migratory inhibition when compared to PTX alone. Mechanistic study shows that the ADORA2A pathway in TNBC is down‐regulated by the combination treatment via mediating epithelial‐to‐mesenchymal transition (EMT) process. In addition, the combined treatment of TSN and PTX significantly attenuates the tumor growth when compared to PTX monotherapy in a mouse model bearing 4T1 tumor. The results suggest that combination of TSN and PTX is superior to PTX alone, suggesting that it may be a promising alternative adjuvant chemotherapy strategy for patients with TNBC, especially those with metastatic TNBC.
Bioinspired Intervertebral Disc with Multidirectional Stiffness Prepared via Multimaterial Additive Manufacturing
Authors: Song Guangsheng , Qian Zhihui , Liu Xiangyu , Chen Boya , Li Guanghui , Wang Zhenguo , Wang Kunyang , Zou Zhenmin , Galbusera Fabio , Domingos Marco , Ren Lei , Wilke Hans‐Joachim , Ren Luquan 
Published: July 2023

AbstractDegenerative disc disease (DDD) has become a significant public health issue worldwide. This can result in loss of spinal function affecting patient health and quality of life. Artificial total disc replacement (A‐TDR) is an effective approach for treating symptomatic DDD that compensates for lost functionality and helps patients perform daily activities. However, because current A‐TDR devices lack the unique structure and material characteristics of natural intervertebral discs (IVDs), they fail to replicate the multidirectional stiffness needed to match physiological motions and characterize anisotropic behavior. It is still unclear how the multidirectional stiffness of the disc is affected by structural parameters and material characteristics. Herein, a bioinspired intervertebral disc (BIVD‐L) based on a representative human lumbar segment is developed. The proposed BIVD‐L reproduces the multidirectional stiffness needed for the most common physiological kinematic behaviors. The results demonstrate that the multidirectional stiffness of the BIVD‐L can be regulated by structural and material parameters. The results of this research deepen knowledge of the biomechanical behavior of the human lumbar disc and may provide new inspirations for the design and fabrication of A‐TDR devices for both engineering and functional applications.
Unleashing the Potential of Sodium‐Ion Batteries: Current State and Future Directions for Sustainable Energy Storage
Authors: Singh Aditya Narayan , Islam Mobinul , Meena Abhishek , Faizan Muhammad , Han Daseul , Bathula Chinna , Hajibabaei Amir , Anand Rohit , Nam Kyung‐Wan 
Published: July 2023

AbstractRechargeable sodium‐ion batteries (SIBs) are emerging as a viable alternative to lithium‐ion battery (LIB) technology, as their raw materials are economical, geographically abundant (unlike lithium), and less toxic. The matured LIB technology contributes significantly to digital civilization, from mobile electronic devices to zero electric‐vehicle emissions. However, with the increasing reliance on renewable energy sources and the anticipated integration of high‐energy‐density batteries into the grid, concerns have arisen regarding the sustainability of lithium due to its limited availability and consequent price escalations. In this context, SIBs have gained attention as a potential energy storage alternative, benefiting from the abundance of sodium and sharing electrochemical characteristics similar to LIBs. Furthermore, high‐entropy chemistry has emerged as a new paradigm, promising to enhance energy density and accelerate advancements in battery technology to meet the growing energy demands. This review uncovers the fundamentals, current progress, and the views on the future of SIB technologies, with a discussion focused on the design of novel materials. The crucial factors, such as morphology, crystal defects, and doping, that can tune electrochemistry, which should inspire young researchers in battery technology to identify and work on challenging research problems, are also reviewed.
Polyglycerol‐Based Biomedical Matrix for Immunomagnetic Circulating Tumor Cell Isolation and Their Expansion into Tumor Spheroids for Drug Screening
Authors: Tang Peng , Thongrom Boonya , Arora Smriti , Haag Rainer 
Published: July 2023

AbstractCirculating tumor cells (CTCs) are established as distinct cancer biomarkers for diagnosis, as preclinical models, and therapeutic targets. Their use as preclinical models is limited owing to low purity after isolation and the lack of effective techniques to create 3D cultures that accurately mimic in vivo conditions. Herein, a two‐component system for detecting, isolating, and expanding CTCs to generate multicellular tumor spheroids that mimic the physiology and microenvironment of the diseased organ is proposed. First, an antifouling biointerface on magnetic beads is fabricated by adding a bioinert polymer layer and conjugation of biospecific ligands to isolate cancer cells, dramatically enhancing the selectivity and purity of the isolated cancer cells. Next, the isolated cells are encapsulated into self‐degradable hydrogels synthesized using a thiol‐click approach. The hydrogels are mechanochemically tuned to enable tumor spheroid growth to a size greater than 300 µm and to further release the grown spheroids while retaining their tumor‐like characteristics. In addition, drug treatment highlights the need for 3D culture environments rather than conventional 2D culture. The designed biomedical matrix shows potential as a universal method to ensure mimicry of in vivo tumor characteristics in individual patients and to improve the predictability of preclinical screening of personalized therapeutics.
A Flexible Tough Hydrovoltaic Coating for Wearable Sensing Electronics
Authors: Li Lianhui , Zheng Zhuo , Ge Changlei , Wang Yongfeng , Dai Hao , Li Lili , Wang Shuqi , Gao Qiang , Liu Mengyuan , Sun Fuqin , Zhang Ting 
Published: July 2023

AbstractThe lack of a strong binding mechanism between nanomaterials severely restricts the advantages of the evaporation‐driven hydrovoltaic effect in wearable sensing electronics. It is a challenging task to observably improve the mechanical toughness and flexibility of hydrovoltaic devices to match the wearable demand without abandoning the nanostructures and surface function. Here, a flexible tough polyacrylonitrile/alumina (PAN/Al2O3) hydrovoltaic coating with both good electricity generation (open‐circuit voltage, Voc ≈ 3.18 V) and sensitive ion sensing (2285 V M−1 for NaCl solutions in 10−4 to 10−3 m) capabilities is developed. The porous nanostructure composed of Al2O3 nanoparticles is firmly locked by the strong binding effect of PAN, giving a critical binding force 4 times that of Al2O3 film to easily deal with 9.92 m s−1 strong water‐flow impact. Finally, skin‐tight and non‐contact device structures are proposed to achieve wearable multifunctional self‐powered sensing directly using sweat. The flexible tough PAN/Al2O3 hydrovoltaic coating breaks through the mechanical brittleness limitation and broadens the applications of the evaporation‐induced hydrovoltaic effect in self‐powered wearable sensing electronics.
Unlocking High‐Performance Ammonium‐Ion Batteries: Activation of In‐Layer Channels for Enhanced Ion Storage and Migration
Authors: Zhang Xiangyong , Wei Hua , Ren Baohui , Jiang Jingjing , Qu Guangmeng , Yang Jinlong , Chen Guangming , Li Hongfei , Zhi Chunyi , Liu Zhuoxin 
Published: July 2023

AbstractAmmonium‐ion batteries, leveraging non‐metallic ammonium ions, have arisen as a promising electrochemical energy storage system; however, their advancement has been hindered by the scarcity of high‐performance ammonium‐ion storage materials. In this study, an electrochemical phase transformation approach is proposed for the in situ synthesis of layered VOPO4·2H2O (E‐VOPO) with predominant growth on the (200) plane, corresponding to the tetragonal channels on the (001) layers. The findings reveal that these tetragonal in‐layer channels not only furnish NH4+ storage sites but also enhance transfer kinetics by providing rapid cross‐layer migration pathways. This crucial aspect has been largely overlooked in previous studies. The E‐VOPO electrode exhibits exceptional ammonium‐ion storage performance, including significantly increased specific capacity, enhanced rate capability, and robust cycling stability. The resulting full cell can be stably operated for 12 500 charge–discharge cycles at 2 A g−1 for over 70 days. The proposed approach offers a new strategy for meticulously engineering electrode materials with facilitated ion storage and migration, thereby paving the way for developing more efficient and sustainable energy storage systems.
Completely Activated and Phase‐Transformed KFeMnHCF for Zn/K Hybrid Batteries with 14 500 Cycles by an OH‐Rich Hydrogel Electrolyte
Authors: Li Chuan , Li Qing , Wu Zhuoxi , Wang Yiqiao , Zhang Rong , Cui Huilin , Hou Yue , Liu Jiahua , Huang Zhaodong , Zhi Chunyi 
Published: July 2023

AbstractMetal hexacyanoferrates are recognized as superior cathode materials for zinc and zinc hybrid batteries, particularly the Prussian blue analog (PBA). However, PBA development is hindered by several limitations, including small capacities (<70 mAh g−1) and short lifespans (<1000 cycles). These limitations generally arise due to incomplete activation of redox sites and structure collapse during intercalation/deintercalation of metal ions in PBAs. According to this study, the adoption of a hydroxyl‐rich (OH‐rich) hydrogel electrolyte with extended electrochemical stability windows (ESWs) can effectively activate the redox site of low‐spin Fe of the KxFeyMn1−y[Fe(CN)6]w·zH2O (KFeMnHCF) cathode while tuning its structure. Additionally, the strong adhesion of the hydrogel electrolyte inhibits KFeMnHCF particles from falling off the cathode and dissolving. The easy desolvation of metal ions in the developed OH‐rich hydrogel electrolytes can lead to a fast and reversible intercalation/deintercalation of metal ions in the PBA cathode. As a result, the Zn||KFeMnHCF hybrid batteries achieve the unprecedented characteristics of 14 500 cycles, a 1.7 V discharge plateau, and a 100 mAh g−1 discharge capacity. The results of this study provide a new understanding of the development of zinc hybrid batteries with PBA cathode materials and present a promising new electrolyte material for this application.
Unlocking the Stability of Reduced Graphene Oxide Nanosheets in Biological Media via Use of Sodium Ascorbate
Authors: Amato Francesco , Perini Giordano , Friggeri Ginevra , Augello Alberto , Motta Alessandro , Giaccari Leonardo , Zanoni Robertino , De Spirito Marco , Palmieri Valentina , Marrani Andrea Giacomo , Papi Massimiliano 
Published: July 2023

AbstractGraphene oxide and reduced graphene oxide (RGO) are carbon bidimensional nanomaterials largely exploited in biomedicine. Their unique interactions with eukaryotic and prokaryotic cells are used to obtain precise intracellular delivery, to create device coatings, and to design theranostic materials for both therapeutic and imaging applications, mainly in the cancer research field. It is known, however, that the hydrophobic behavior of RGO limits its stability in biological media. Here, the employment of sodium ascorbate (NaA) as a reducing agent for the preparation of RGO to provide a nanomaterial with remarkable suitability for applications in cell culture media is proposed. It is demonstrated via a combined experimental and theoretical approach that NaA is able to yield a peculiar RGO derivative, exerting a twofold effect, that is, C sp2 network restoration upon epoxide reduction and RGO edge functionalization via H‐bonding, lending RGO a so far unexampled dispersibility in aqueous‐based media. The kinetic stability of the bidimensional layers of RGO obtained from NaA is demonstrated together with its superior biocompatibility for drug delivery, unlocking outstanding potentialities for biological applications.
Facile and Scalable Fabrication of Hydrophilic/Hydrophobic Janus Fabric for Personal Sweat Monitoring and Perspiration Management
Authors: Liu Yingcun , Li Juan , Xu Duo , Su Ziyi , Ge Can , Chen Ze , Xu Weilin , Liu Keshuai 
Published: July 2023

AbstractQuantifiable monitoring and management of sweat volume have attracted considerable attention because of their role in assessing physiological health and preventing dehydration. However, defective sweat monitoring and poor moisture management limit the performance of most smart textiles under moderate/profuse perspiration scenarios. In this study, a large‐scale fabrication technology is used, including braiding and weaving, to prepare a hydrophilic/hydrophobic Janus fabric (HHJF) with good directional water delivery and sweat‐volume monitoring capabilities. The HHJF consists of polytetrafluoroethylene (PTFE) braided yarns (lower layer) and Tencel braided yarns (upper layer), which comprise a conductive yarn as the core and PTFE/Tencel yarns as the sheath with enhanced water absorption capacity. The unique functional structure design achieves the enhanced unidirectional water transport and high sweat‐sensing response for the HHJF under perspiration conditions. The optimized HHJF facilitates spontaneous droplet penetration from the hydrophobic layer to the hydrophilic layer, while enabling the real‐time detection of sweat volume of up to 2000 mL m−2with excellent durability for over 1000 cycle tests. Thus, the exceptional perspiration management and monitoring capabilities of HHJF are expected to promote the development of practical smart textiles that enable real‐time monitoring of perspiration dynamics.
Highly Sensitive Broadband Bolometric Photodetectors based on 2D PdSe2 Thin Film
Authors: Zhang Rui , Yang Zhuojun , Liu Liwen , Lin Jie , Wen Shaofeng , Meng You , Yin Yi , Lan Changyong , Li Chun , Liu Yong , Ho Johnny C. 
Published: July 2023

AbstractPdSe2, a semiconductor with a narrow band gap, shows tremendous promise for high‐performance broadband photodetectors. In this study, highly sensitive, broadband, and flexible PdSe2 thin film photodetectors on polyimide (PI) substrates that can detect light from the UV (365 nm) to infrared (2200 nm) regions are reported. The devices with thick (21 nm) PdSe2 films show decent performance with a decent responsivity of 37.6 mA W−1 at 1550 nm and a fast response time. For the thick PdSe2 film, the bolometric effect dominates the positive photoresponse across all wavelength regions, whereas for the thin PdSe2 film (4.5–13 nm), which shows both positive and negative photoresponses, it dominates in the infrared region. The negative photoresponse of thin PdSe2 in the UV to the VIS region is attributed to the charge transfer‐related adsorption‐desorption of gas molecules. Detailed investigations revealed that the temperature coefficient of resistance (TCR) value is closely correlated to film thickness, with the thinnest film exhibiting the highest absolute TCR value of up to 4.3% °C−1. The value is much larger than that of metals, most 2D materials, amorphous Si, and even commercial VOx. These findings suggest that PdSe2 films have a promising future in broadband photodetectors.
Modular Photochemical Flow Synthesis of Structurally Diverse Benzyne and Triazine Precursors
Authors: García‐Lacuna Jorge , Baumann Marcus 
Published: July 2023

AbstractBenzyne and related arynes are classical high‐energy species with a rich history of widespread applications in synthesis. However, despite several synthetic routes being available to generate arynes and their precursors, none represents an ideal entry to benzyne chemistry in view of safety, scalability, and sustainability. Here we report a new photochemical flow process allowing for the generation of benzyne precursors in high yields, and throughput, with easy isolation of multigram quantities of products. This process leverages a catalyst‐free photochemical rearrangement via a photoexcited nitro arene which involves a cyclic hydroxylamine intermediate that has been fully characterized. The resulting precursors were converted to benzynes via a second photochemical flow process generating heterocyclic targets upon trapping with azide and sydnone partners. Remarkably, when reacting the benzyne precursors with secondary amines, a wide range of aryl triazines is obtained in good yields via a third photo‐flow transformation. This represents a modular approach to synthesize these species, that avoids the use of potentially explosive diazonium salts. Ultimately, three photochemical flow processes using a single high‐power LED light source (365 nm, adjustable in‐put power) are presented with manifest benefits compared to batch processing. Moreover, the functionalization of a pendent carboxyl group to form sets of biologically relevant aryl triazine‐based amides highlights further applications of these unique and industrially relevant triazine entities.
Male‐Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development
Authors: Wang Ling , Tu Yi‐Xuan , Chen Lu , Zhang Yuan , Pan Xue‐Ling , Yang Shu‐Qiao , Zhang Shuai‐Jie , Li Sheng‐Hui , Yu Ke‐Chun , Song Shuo , Xu Hong‐Li , Yin Zhu‐Cheng , Yue Jun‐Qiu , Ni Qian‐Lin , Tang Tang , Zhang Jiu‐Liang , Guo Min , Zhang Shuai , Yao Fan , Liang Xin‐Jun , Chen Zhen‐Xia 
Published: July 2023

AbstractMen demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than women. This study aims to explain the potential causes of such sexual dimorphism in CRC from the perspective of sex‐biased gut microbiota and metabolites. The results show that sexual dimorphism in colorectal tumorigenesis is observed in both ApcMin/+ mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)‐treated mice with male mice have significantly larger and more tumors, accompanied by more impaired gut barrier function. Moreover, pseudo‐germ mice receiving fecal samples from male mice or patients show more severe intestinal barrier damage and higher level of inflammation. A significant change in gut microbiota composition is found with increased pathogenic bacteria Akkermansia muciniphila and deplets probiotic Parabacteroides goldsteinii in both male mice and pseudo‐germ mice receiving fecal sample from male mice. Sex‐biased gut metabolites in pseudo‐germ mice receiving fecal sample from CRC patients or CRC mice contribute to sex dimorphism in CRC tumorigenesis through glycerophospholipids metabolism pathway. Sexual dimorphism in tumorigenesis of CRC mouse models. In conclusion, the sex‐biased gut microbiome and metabolites contribute to sexual dimorphism in CRC. Modulating sex‐biased gut microbiota and metabolites could be a potential sex‐targeting therapeutic strategy of CRC.
Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration
Authors: Shi Yu , Li Hanwen , Chu Dongchuan , Lin Wenzheng , Wang Xinglong , Wu Yin , Li Ke , Wang Huihui , Li Dandan , Xu Zhuobin , Gao Lizeng , Li Bin , Chen Hao 
Published: July 2023

AbstractHigh levels of reactive oxygen species (ROS) lead to progressive deterioration of mitochondrial function, resulting in tissue degeneration. In this study, ROS accumulation induced nucleus pulposus cells (NPCs) senescence is observed in degenerative human and rat intervertebral disc, suggesting senescence as a new therapeutic target to reverse intervertebral disc degeneration (IVDD). By targeting this, dual‐functional greigite nanozyme is successfully constructed, which shows the ability to release abundant polysulfides and presents strong superoxide dismutase and catalase activities, both of which function to scavenge ROS and maintain the tissue at physical redox level. By significantly lowering the ROS level, greigite nanozyme rescues damaged mitochondrial function in IVDD models both in vitro and in vivo, rescues NPCs from senescence and alleviated the inflammatory response. Furthermore, RNA‐sequencing reveals ROS‐p53‐p21 axis is responsible for cellular senescence‐induced IVDD. Activation of the axis abolishes greigite nanozyme rescued NPCs senescence phenotype, as well as the alleviated inflammatory response to greigite nanozyme, which confirms the role of ROS‐p53‐p21 axis in greigite nanozyme's function to reverse IVDD. In conclusion, this study demonstrates that ROS‐induced NPCs senescence leads to IVDD and the dual‐functional greigite nanozyme holds strong potential to reverse this process, providing a novel strategy for IVDD management.
Multi‐Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging
Authors: Huang Jiana , Chen Peigen , Jia Lei , Li Tingting , Yang Xing , Liang Qiqi , Zeng Yanyan , Liu Jiawen , Wu Taibao , Hu Wenqi , Kee Kehkooi , Zeng Haitao , Liang Xiaoyan , Zhou Chuanchuan 
Published: July 2023

AbstractAbnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal aging. Transcriptional silencing makes translational control an urgent task during meiosis resumption in maternal aging. However, insights into aging‐related translational characteristics and underlying mechanisms are limited. Here, using multi‐omics analysis of oocytes, it is found that translatomics during aging is related to changes in the proteome and reveals decreased translational efficiency with aging phenotypes in mouse oocytes. Translational efficiency decrease is associated with the N6‐methyladenosine (m6A) modification of transcripts. It is further clarified that m6A reader YTHDF3 is significantly decreased in aged oocytes, inhibiting oocyte meiotic maturation. YTHDF3 intervention perturbs the translatome of oocytes and suppress the translational efficiency of aging‐associated maternal factors, such as Hells, to affect the oocyte maturation. Moreover, the translational landscape is profiled in human oocyte aging, and the similar translational changes of epigenetic modifications regulators between human and mice oocyte aging are observed. In particular, due to the translational silence of YTHDF3 in human oocytes, translation activity is not associated with m6A modification, but alternative splicing factor SRSF6. Together, the findings profile the specific translational landscapes during oocyte aging in mice and humans, and uncover non‐conservative regulators on translation control in meiosis resumption and maternal aging.