bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non‐inducing cancer cells
Authors: Chitti Sai V. , Kang Taeyoung , Fonseka Pamali , Marzan Akbar L. , Stewart Sarah , Shahi Sanjay , Bramich Kyle , Ang Ching‐Seng , Pathan Mohashin , Gummadi Sriram , Mathivanan Suresh 
Published: June 2023

AbstractCancer cachexia is a wasting syndrome characterised by the loss of fat and/or muscle mass in advanced cancer patients. It has been well‐established that cancer cells themselves can induce cachexia via the release of several pro‐cachectic and pro‐inflammatory factors. However, it is unclear how this process is regulated and the key cachexins that are involved. In this study, we validated C26 and EL4 as cachexic and non‐cachexic cell models, respectively. Treatment of adipocytes and myotubes with C26 conditioned medium induced lipolysis and atrophy, respectively. We profiled soluble secreted proteins (secretome) as well as small extracellular vesicles (sEVs) released from cachexia‐inducing (C26) and non‐inducing (EL4) cancer cells by label‐free quantitative proteomics. A total of 1268 and 1022 proteins were identified in the secretome of C26 and EL4, respectively. Furthermore, proteomic analysis of sEVs derived from C26 and EL4 cancer cells revealed a distinct difference in the protein cargo. Functional enrichment analysis using FunRich highlighted the enrichment of proteins that are implicated in biological processes such as muscle atrophy, lipolysis, and inflammation in both the secretome and sEVs derived from C26 cancer cells. Overall, our characterisation of the proteomic profiles of the secretory factors and sEVs from cachexia‐inducing and non‐inducing cancer cells provides insights into tumour factors that promote weight loss by mediating protein and lipid loss in various organs and tissues. Further investigation of these proteins may assist in highlighting potential therapeutic targets and biomarkers of cancer cachexia.
Skin metastasis in squamous cell cancer of cervix: A case report
Authors: Zhao Xiujuan , Chen Rui , Zhou Qi 
Published: June 2023

AbstractCervical cancer, the fourth most common cancer among females in the world, ranks the second in China. In advanced disease, metastases may be commonly present in the lungs, bones, liver and lymph nodes or elsewhere, but uncommon to the skin. In this report, a 63‐year‐old woman was diagnosed as stage IVB cervical squamous cell cancer in January 2021. The patient was scheduled for concurrent chemoradiotherapy; however, a metastatic lesion of skin was proved by biopsy during the process of treatment. She died 1 month after confirmed skin metastases. Cutaneous metastasis of cervical cancer may predict the mix of lymphatic and hematogenous metastasis and the rapid fatal termination.
Anisotropic Stellar Systems in f(R)$f(R)$ Connected Static Spacetime
Authors: Sufyan M. , Ahmad Daud , Almutairi Bander , Khan A. S. 
Published: June 2023

AbstractThe idea of this paper is to look some anisotropic star models in a metric approach, where R is the Ricci scalar. The Karmarkar and Tolman system is used to analyze the physics of some spherically symmetric stars using two independent computational gravitational theories. The behavior of structural factors is evaluated using diagrams, and the feasibility of compact objects is investigated using boundary conditions for the involved constants. The investigation in the profiles of the effective energy/matter states, the equilibrium phases, and the Tolman‐Oppenheimer‐Volkoff models and stability analysis is performed for various realistic candidates of stars. Under a few important cosmological backgrounds, the assessment of our graphics may offer assistance in the search of the realistic and viable gravitational models.
Using credible failure rates for SIS ensures process safety: A summary of the panel discussion
Authors: Bukowski Julia V. , Summers Angela E. , Goble William M. , Limaye Rajeev , Gutierrez Juan 
Published: June 2023

AbstractOn March 13, 2023, in conjunction with the 19th Global Congress on Process Safety, four of the authors gathered to participate in a panel session. The discussion centered on the premise that many individual device failure rates published by some manufacturers and some certifying agencies are deemed—by members of the panel, many safety instrumented system (SIS) designers, and practicing engineers in the field—to be too low. This is especially true for mechanical final elements. A SIS designed using these unrealistic failure rates often results in estimated safety integrity levels (SILs) for the individual safety instrumented functions (SIFs) comprising the SIS, which would be achievable only under the most optimistic assumptions regarding installation, operation, and maintenance. These estimated SILs are unlikely to be achieved in the field. The panel discussed the underlying causes of this serious safety issue and proposed some possible solutions. This paper summarizes the panel discussion among four of the authors. Relevant graphics shown during the discussion and some panelists' quotations are included.
Spatiotemporal estimation of analysis errors in the operational global data assimilation system at the China Meteorological Administration using a modified SAFE method
Authors: Feng Jie , Wang Jincheng , Dai Guokun , Zhou Feifan , Duan Wansuo 
Published: June 2023

AbstractQuantification of the uncertainties in initial analyses against the real atmosphere (“reality”) provides a fundamental reference for the evaluation and development of operational data assimilation (DA) systems. Due to the unknown reality, most existing methods for analysis error estimation use reanalysis datasets or observations as a proxy for reality, which are empirical, non‐objective, and biased. Unlike these methods, our study adopted a modified Statistical Analysis and Forecast Error (SAFE) estimation method to objectively and directly quantify spatiotemporal errors in analyses compared to reality based on unbiased assumptions. In the present study, the SAFE method was first applied to estimate the annual variation and spatial distribution of analysis errors in the Global Forecast System of Global/Regional Assimilation and PrEdiction System (GRAPES_GFS) at the China Meteorological Administration (CMA) since the beginning of its operational implementation (i.e., 2016–2021). Qualitative comparison to analysis error estimations in previous studies showed that SAFE can provide more reasonable spatial‐mean analysis error profiles than can the estimation with the ERA‐5 reanalysis as a reference (the approach hereafter called “ERAv”). Moreover, ERAv overestimates (underestimates) the spatial‐mean analysis error below (above) approximately 500 hPa compared to SAFE because it neglects the uncertainties inherent in reanalysis. Overall, the SAFE estimation reveals that relative reductions of about 12.5%, 29%, and 24.5% were achieved for the spatial‐mean analysis errors of wind, temperature, and geopotential height, respectively, in the GRAPES_GFS throughout the six‐year study period. These results can largely be attributed to the DA scheme being upgraded from 3D‐Var to 4D‐Var. SAFE can also provide more reasonable and accurate pointwise analysis errors than ERAv can.
Disentangling the corporate effect on subsidiary performance
Authors: Andrews Daniel S. , Fainshmidt Stav , Fitza Markus , Kundu Sumit 
Published: June 2023

AbstractResearch SummaryCorporate parents are important to subsidiary performance, but prior strategy research presents mixed results about the extent to which parents drive subsidiary performance differences. Drawing on the corporate strategy literature, we argue that corporate parents’ influence depends on the size of the corporate portfolio that determines subsidiaries’ access to finite corporate resources and the contextual conditions—industrial relatedness and institutional distance—that favor or constrain the applicability of said resources. We find support using a variance decomposition analysis and data on 12,336 subsidiaries of 854 multinational firms. Our study demonstrates that the corporate effect varies according to the structure of the corporate portfolio and the subsidiaries in it. We reconcile theoretical arguments and empirical findings regarding the relative importance of corporate parents to subsidiary performance.Managerial SummaryA core objective of corporate managers is understanding those channels most salient to subsidiary performance. The implicit assumption is that the corporate parent matters, but how much so remains unclear, especially since corporate parents cannot contribute equally to all subsidiaries. We demonstrate that the corporate parents of small subsidiary portfolios play a significant role in explaining subsidiary performance differences vis‐à‐vis parents of larger portfolios. We also show how this relative importance increases when subsidiaries exhibit higher industrial relatedness to and institutional distance from the parent. Our findings offer insights into the role of corporate parents in multiunit firms that operate across multiple industries and geographic locations, as well as the need to consider the heterogeneity of corporate influence within and between subsidiary portfolios.
Neoliberalizing Subjects through Global ELT Programs
Authors: Shah Waqar Ali , Pardesi Hajra Y. , Memon Talha 
Published: June 2023

AbstractA recent surge in textbooks studies has revealed a closer link with neoliberalism and the way they construct neoliberal subjects. This paper uses Foucauldian governmentality as the conceptual lens to analyze the neoliberal discourses in EFL textbooks used in English Access Microscholarship (EAM)—one of the US‐aided global ELT programs in Pakistan. English language learners' views on course outcomes and textbooks were also examined. The study shows that among others, English as a neoliberal life skill, celebrity culture, consumerism, entrepreneurship, and individual and corporate social responsibility dominate textbooks. It is thus found that textbooks play an important role in neoliberalizing learners. Moreover, English language learners perceive English as a key to economic success. They also value consumerism, branding, and personal responsibility. In light of the study findings, we suggest a decolonial option, reflective activism, and post‐method pedagogy as possible alternatives at the micro‐, meso‐, and macro‐levels to resist the discourses of neoliberalism and colonial power patterns entrenched in a postcolonial society like Pakistan.
Negotiating (Employable) Graduate Identity: Small Story Approach in Qualitative Follow-up Research
Authors: Siivonen Päivi , Korhonen Maija , Komulainen Katri , Mutanen Heli , Haltia Nina 
Published: June 2023

AbstractIn this methodological chapter, narrative positioning analysis in qualitative follow-up research is developed to analyse continuity and change of (employable) graduate identity through time. The analysis is illustrated with one business graduate’s example that was chosen as the educational and working life trajectory consists of breaks that require identity negotiation in relation to the normative ideals of employability. Narrative analysis permits the reading of graduate identity as an emergent phenomenon, making diverse positionings in relation to employability visible. Continuous negotiation of graduate identity implies that there is no single end-point in employability, but instead employability is a socially constructed process in which identity work has become salient to pursuing opportunities in working life. Moreover, our study shows that the normative employable ideal of an enterprising graduate identity is not equally available for those coming from a working-class background.
Einleitung: Phänomenologie des Leibes und der Leiblichkeit bei Marc Richir
Authors: Ekweariri Dominic Nnaemeka 
Published: June 2023

ZusammenfassungWährend Edward Osborne Wilson in der Soziobiologie die Kooperation zwischen diversen Gruppen als vorteilhaft für das Überleben der Spezies und die Ermöglichung komplexerer sozialer Ordnung versteht, versuchen wir zu zeigen, dass die Leiblichkeit ursprünglicher als die Kooperation und in der Phänomenologie seit Husserl als Bedingung nicht nur für ein mögliches soziales Leben, sondern auch für Welterschließung ist. Kooperation setzt daher die Leiblichkeit voraus, welche erst das Verstehen und die Kommunikation zwischen Menschen garantiert. Wenn das „Apriori der Leiblichkeit“ eine Bedingung zur Sozialität, zur Kommunikation usw. mit einem anderen Subjekt ist, so kann gesagt werden, dass das Subjekt in einer bestimmten Haltung und Beziehung zu seiner Umwelt steht. Richir schließt sich dem phänomenologischen Ausgangspunkt seit Husserl an, dass das Selbst als erfahrendes Subjekt sowohl über eine private, psychische [Leib], als auch eine öffentliche, physische Seite [Körper] verfügt und dass das Selbst nicht ohne sein Verhältnis zur Welt [Leiblichkeit] denkbar ist, um dann diese Ansätze neu zu denken. Bei Richir jedoch betrifft der Leib nicht nur das menschliche Wesen als ein erfahrendes, lebendiges Selbst, sondern artikuliert auch den Überschuss der Erfahrung, ohne den Leib aber symbolisch zu überbestimmen, aber dafür das spannungsvolle Verhältnis desselben im Abstand mit der symbolischen Institution zu artikulieren. Was aber die Leiblichkeit angeht, so distanziert sich Richir von sowohl Husserls Art der Weltbezüglichkeit, die die Intentionalität als allgemeingültige Struktur der Erschließung des Phänomens voraussetzt, als auch von Heideggers ontologisch aufgeladener Welterschließung. So ist also die Aufgabe einer phänomenologischen Analyse, den Überschuss der Leiblichkeit zu erklären, der zwischen dem Symbolischen und dem Nichtsymbolischen schwankt. Dieses Kapitel stellt – neben der Herausforderung, der Einschränkung, der Methodik und der Struktur der Arbeit – die These der Arbeit vor, dass dieser Überschuss in Richirs Phänomenologie in der Affektivität, im „Gefühl“, bei der Empfindung zur Wahrnehmung, im Denken usw. als Überschuss des Sprachlichen zu erforschen ist.
Schlussfolgerung, Diskussion und Ausblick
Authors: Ekweariri Dominic Nnaemeka 
Published: June 2023

ZusammenfassungWir sind am Ende unserer Untersuchung angelangt. In diesem abschließenden Teil halten wir es für angebracht, die vorangegangenen Kapitel in einen geschlossenen Bogen einzufügen. Danach gehen wir zu einer Diskussion über, die einen Ausblick auf das Forschungsfeld zu Richirs Phänomenologie eröffnet.
SaxoForN – Transregionales allgemeinmedizinisches Forschungspraxennetz Dresden und Frankfurt am Main
Authors: Mergenthal Karola , Güthlin Corina , Klein Astrid A. , Engler Jennifer , Gerber Meike , Petermann Jenny , Piller Steve , Bergmann Antje , Gerlach Ferdinand M. , Voigt Karen 
Published: June 2023

ZusammenfassungEtablierte allgemeinmedizinische Forschungspraxennetze (FPN) erleichtern die Durchführung von klinischen Studien sowie Studien der Versorgungsforschung im hausärztlichen Setting. Seit Februar 2020 fördert das Bundesministerium für Bildung und Forschung (BMBF) deutschlandweit den Aufbau von 6 allgemeinmedizinischen FPN und einer Koordinierungsstelle, um eine nachhaltige ambulante Forschungsinfrastruktur aufzubauen und so die Quantität und Qualität der Forschung in der Primärversorgung zu erhöhen.Im vorliegenden Artikel wird das Konzept des „Allgemeinmedizinischen Forschungspraxennetzes Dresden/Frankfurt am Main – SaxoForN“ vorgestellt und dessen innovative Funktionsweise und Strukturen erläutert. Es handelt sich um einen transregionalen Verbund der beiden regionalen FPN mit den Namen „SaxoN“ (Dresden/Sachsen) und „ForN“ (Frankfurt am Main/Hessen), die sowohl transregional als auch lokal Forschungsprojekte umsetzen. Dafür wurden gemeinsame Standards konsentiert und harmonisierte Strukturen, z. B. zur Dateninfrastruktur, Qualifizierung, Partizipation sowie Akkreditierung, entwickelt und an beiden Standorten implementiert.Ein kritischer Erfolgsfaktor wird sein, ob und inwiefern die Standards und Strukturen sowie die Ressourcenplanung nachhaltig gestaltet werden können, um langfristig qualitativ gute Forschung über die FPN zu ermöglichen. Dazu gehören die Akquise und langfristige Bindung der Praxen an das FPN, die Qualifizierung der Forschungspraxenteams sowie eine möglichst weitgehende Standardisierung der Prozesse, regelmäßige Dokumentation von Basisdaten und Versorgungsdaten aus den Praxen.
RELA governs a network of islet-specific metabolic genes necessary for beta cell function
Authors: Zammit Nathan W. , Wong Ying Ying , Walters Stacey N. , Warren Joanna , Barry Simon C. , Grey Shane T. 
Published: June 2023

Abstract
Aims/hypothesis
NF-κB activation unites metabolic and inflammatory responses in many diseases yet less is known about the role that NF-κB plays in normal metabolism. In this study we investigated how RELA impacts the beta cell transcriptional landscape and provides network control over glucoregulation.

Methods
We generated novel mouse lines harbouring beta cell-specific deletion of either the Rela gene, encoding the canonical NF-κB transcription factor p65 (βp65KO mice), or the Ikbkg gene, encoding the NF-κB essential modulator NEMO (βNEMOKO mice), as well as βA20Tg mice that carry beta cell-specific and forced transgenic expression of the NF-κB-negative regulator gene Tnfaip3, which encodes the A20 protein. Mouse studies were complemented by bioinformatics analysis of human islet chromatin accessibility (assay for transposase-accessible chromatin with sequencing [ATAC-seq]), promoter capture Hi-C (pcHi-C) and p65 binding (chromatin immunoprecipitation–sequencing [ChIP-seq]) data to investigate genome-wide control of the human beta cell metabolic programme.

Results
Rela deficiency resulted in complete loss of stimulus-dependent inflammatory gene upregulation, consistent with its known role in governing inflammation. However, Rela deletion also rendered mice glucose intolerant because of functional loss of insulin secretion. Glucose intolerance was intrinsic to beta cells as βp65KO islets failed to secrete insulin ex vivo in response to a glucose challenge and were unable to restore metabolic control when transplanted into secondary chemical-induced hyperglycaemic recipients. Maintenance of glucose tolerance required Rela but was independent of classical NF-κB inflammatory cascades, as blocking NF-κB signalling in vivo by beta cell knockout of Ikbkg (NEMO), or beta cell overexpression of Tnfaip3 (A20), did not cause severe glucose intolerance. Thus, basal p65 activity has an essential and islet-intrinsic role in maintaining normal glucose homeostasis. Genome-wide bioinformatic mapping revealed the presence of p65 binding sites in the promoter regions of specific metabolic genes and in the majority of islet enhancer hubs (~70% of ~1300 hubs), which are responsible for shaping beta cell type-specific gene expression programmes. Indeed, the islet-specific metabolic genes Slc2a2, Capn9 and Pfkm identified within the large network of islet enhancer hub genes showed dysregulated expression in βp65KO islets.

Conclusions/interpretation
These data demonstrate an unappreciated role for RELA as a regulator of islet-specific transcriptional programmes necessary for the maintenance of healthy glucose metabolism. These findings have clinical implications for the use of anti-inflammatories, which influence NF-κB activation and are associated with diabetes.

Graphical Abstract
Geographical variation in treated psychotic and other mental disorders in Finland by region and urbanicity
Authors: Suokas Kimmo , Kurkela Olli , Nevalainen Jaakko , Suvisaari Jaana , Hakulinen Christian , Kampman Olli , Pirkola Sami 
Published: June 2023

Abstract
Purpose
In Finland, prevalence of schizophrenia is higher in the eastern and northern regions and co-occurs with the distribution of schizophrenia polygenic risk scores. Both genetic and environmental factors have been hypothesized to contribute to this variation. We aimed to examine the prevalence of psychotic and other mental disorders by region and degree of urbanicity, and the impacts of socio-economic adjustments on these associations.

Methods
Nationwide population registers from 2011 to 2017 and healthcare registers from 1975 to 2017. We used 19 administrative and three aggregate regions based on the distribution of schizophrenia polygenic risk scores, and a seven-level urban–rural classification. Prevalence ratios (PRs) were calculated by Poisson regression models and adjusted for gender, age, and calendar year (basic adjustments), and Finnish origin, residential history, urbanicity, household income, economic activity, and physical comorbidity (additional adjustments) on an individual level. Average marginal effects were used to visualize interaction effects between region and urbanicity.

Results
A total of 5,898,180 individuals were observed. All mental disorders were slightly more prevalent (PR 1.03 [95% CI, 1.02–1.03]), and psychotic disorders (1.11 [1.10–1.12]) and schizophrenia (1.19 [1.17–1.21]) considerably more prevalent in eastern and northern than in western coastal regions. After the additional adjustments, however, the PRs were 0.95 (0.95–0.96), 1.00 (0.99–1.01), and 1.03 (1.02–1.04), respectively. Urban residence was associated with increased prevalence of psychotic disorders across all regions (adjusted PR 1.21 [1.20–1.22]).

Conclusion
After adjusting for socioeconomic and sociodemographic factors, the within-country distribution of mental disorders no longer followed the traditional east–west gradient. Urban–rural differences, on the other hand, persisted after the adjustments.
Unusual cause of unilateral facial oedema: intramuscular dirofilariasis
Authors: Dosemane Deviprasad , Khadilkar Meera Niranjan , Sriperumbudur Susmita , Aggarwal Ishaan 
Published: June 2023

Abstract
Introduction
Unilateral facial oedema may occur due to inflammatory, infective, or cystic pathology; patients often seek medical help at an early stage.

Case report
We report one such case caused mimicking a parotid abscess, caused by dirofilariasis.

Conclusion
Dirofilariasis is an emerging zoonosis and should be considered a differential diagnosis of atypical facial swelling. It is equally important for clinicians, radiologists, and pathologists to be familiar with the diagnostic characteristics to avoid misdiagnosis.
A multiphysical computational model of myocardial growth adopted to human pathological ventricular remodelling
Authors: Lee Yongjae , Cansız Barış , Kaliske Michael 
Published: June 2023

AbstractWe present a novel three-dimensional constitutive model that describes an electro-visco-elastic-growth response on the myocardium with a fully implicit staggered solution procedure for the strong electromechanical coupling. The novel formulations of the myocardium allows us to simulate and analyze the remodelling of actively contracting human ventricular heart models which consist of growing viscoelastic myocardium where the growth direction is determined based on its mechanical state at each time step. The total deformation gradient is multiplicatively decomposed into a mechanical-active part and a growth part, where the mechanical-active part is further split into elastic, viscous, and active components. Unconditional stability of time integration is ensured by a backward Euler integration scheme. With the developed model, the myocardium can experience stretch-driven longitudinal (fibre) growth and stress-driven transverse (cross-fibre) growth. To validate the developed approach, two simulations regarding pathological ventricular remodelling are implemented: two divergent types of remodelling of a left ventricular model driven by hemodynamic overloads and ventricular remodelling triggered by acute myocardial ischemia in a biventricular heart model.