bluuebunny/crossref_metadata_2025_split huggingface dataset:
CLASSIFICAÇÃO GEODEMOGRÁFICA E A ASSIMETRIA NA DATAFICAÇÃO DE CRÉDITO
Authors: Pereira Laudelina Leonardo , Silva Tarcízio Roberto 
Published: January 2023

O mercado de compra e venda de dados pessoais tem papel de destaque na economia informacional. Diante do alto volume de informações pessoais, ferramentas de segmentação despertam cada vez mais interesse das organizações, já que por meio de tecnologias de big data, constroem perfis apurados da população. Para compreender as características deste tipo de classificação, analisamos a ferramenta de classificação geodemográfica Mosaic em contraposição a uma de suas aplicações na ponta do consumidor: o Score Serasa. O Mosaic classifica a população brasileira com base no seu poder de consumo em 11 categorias e 40 segmentos. Este método de categorização considera aspectos financeiros, geográficos, demográficos, de consumo, comportamento e estilo de vida. Por sua vez, o Serasa Score é ferramenta compulsória para algumas classes de cidadãos, que precisam entrar no jogo da otimização contínua de seus índices. O estudo analisa a opacidade dos sistemas e assimetrias da classificação geodemográfica.
PERTENCIMENTO RELIGIOSO E VOCAÇÃO POLÍTICA
Authors: Lima Torres Monalisa , Silva Emanuel 
Published: January 2023

O objetivo deste artigo é o de analisar as representações que parlamentares ligados a denominações religiosas elaboram acerca da legitimidade do exercício parlamentar a partir da ideia de vocação, gerada pela própria pertença religiosa. Em outras palavras, pretendemos responder à seguinte questão: a partir de que elementos a pertença religiosa é acionada como legitimadora de pretensões eleitorais e exercício parlamentar no Brasil contemporâneo? Partindo das noções de vocação, legitimidade e trajetória, analisou-se as “razões religiosas” elencadas por dois vereadores da cidade de Fortaleza (Ceará) como mecanismos de legitimação do ingresso e da permanência na política: o católico carismático Jorge Pinheiro (PSDB) e a evangélica da Assembleia de Deus, Priscila Costa (PSC). A vocação política, tal qual mobilizada por esses parlamentares, carrega dois sentidos: por um lado a acepção weberiana de vocação, segundo a qual a atividade política deve servir de meio para a defesa de uma “causa”. Por outro, a própria inserção no campo político, o “chamamento”, por assim dizer, para a atividade representativa deriva da necessidade de grupos de identidade religiosa, a partir de espaços institucionais, incutir sua “visão de mundo cristã” e influenciar políticas públicas que os afetam direta ou indiretamente. O entendimento de que suas atividades políticas cumprem uma “missão” através da estrutura institucional reforça a legitimidade de seus mandatos frente às comunidades religiosas que representam confirmando a ideia de que são vocacionados para a política.
Palavras-chave: Pertença religiosa. Representação política. Vocação política.
In silico De Novo Discovery of Novel Target-specific Drug-like Bidentate Inhibitors of PTP 1B
Authors: Jaswal Shalini , Roy Kankan , Bisht Priya , Gautam Priyadarshi , Verma Sant Kumar 
Published: January 2023

Background:
Protein tyrosine phosphatase 1B (PTP 1B) is a recognized legitimate target for
type 2 diabetes and obesity, collectively designated as ‘diabesity’, even though first-in-class inhibitor is
still awaited. The main cause behind the unachieved target selectivity of investigated inhibitors is the high
degree of sharing of structural homology between PTP 1B and other members of the PTP family.

Objective:
The present work aimed to discover target-specific inhibitors of PTP 1B with bidentate binding
features on both the allosteric and active sites.

Materials and Methods:
We have implicated the amalgamated de novo designing, ADMET screening,
and molecular docking simulations to discover novel drug-like allosteric inhibitors of PTP 1B. The
LEA3D de novo designing platform was used to design novel thiazolidinediones (TZDs) from scratch in
the core of the target on the strict constraints of defined molecular properties of drug-likeness. Molecular
modelling and geometry optimization were done using the ChemOffice package. The druglikeness/
ADMET screening was performed using the TSAR package based on Lipinski’s filter. Molegro
Virtual Docker (MVD) was used for the prediction of binding cavities in the target, estimation of ligandtarget
binding affinities as well as mode of binding interactions.

Results and Discussion:
Novel TZDs (Molecules 1-8) were de novo designed successfully as drug-like
target-specific inhibitors of PTP 1B. The interaction pattern and the energy contribution of ligand (Etotal,
Eintra, Epair) and target (Epair) supported that the generated TZDs showed bidentate inhibition.

Conclusion:
The discovered TZDs can be developed as novel target-specific allosteric inhibitors of PTP
1B after the accomplishment of synthetic and pre-clinical interventions.
Photodynamic Therapy of Cancer: Quality and Prospective of Therapy
based on Photosensitizer
Authors: Malviya Rishabha , Singh Arun Kumar , Moharana Ankita , Prajapati Vedant Kumar , Nirmal Ashish Kumar 
Published: January 2023

Abstract:
To kill cancer cells, photodynamic therapy (PDT) utilizes a light-sensitive medication and
light. Light-sensitive drugs are absorbed by cancerous cells. The cells are then illuminated with a specific
light or laser by a specialist and oxygen that destroys cancer cells is released. The present study
aims to discuss the roles, advancements, and limitations of photodynamic therapy in cancer treatment.
Photosensitizers and photosensitizing agents are used in photodynamic treatment to destroy cancer
cells. Lasers or other light sources, such as LEDs, may provide illumination. There are reports of a
novel nanoplatform for the treatment of HER2-overexpressed breast cancer, as well as other primary
and metastatic cancers, using fluorescent electron microscopy PDT/photothermal therapy (PTT) dualtherapy.
PDT has a significant benefit over conventional cancer therapies because it may cause fewer
adverse effects. PDT-induced immunostimulatory cell death and the production of a robust local inflammatory
response might lead to effective local anticancer therapy. PDT has a lower long-term morbidity
and recovery time than surgery, chemotherapy, or radiation.
The Relationship Between Social Intelligence And IQ: A Psychometric Analysis
Authors: Almat Nuradinov S. , Aliya Mambetаlina S. , Zhanna Utaliyeva T. , Gulmira Davletkaliyeva S. 
Published: January 2023

Background:
The present article deals with the results of research on the psychological diagnosis of social intelligence and its connection with general intelligence.

Methods:
The analysis of the relationship between the Social Intelligence Scale of the University of Tromso, Norway (TSIS) (Social awareness scale, SA) with the R. Amthauer Intelligence Test was carried out on a sample of 407 students of comprehensive schools aged from 12 to 18. Social Intelligence Scales have relationships with R. Amthauer Intelligence Test. Factor analysis has shown that the TSIS (Social Awareness, SA) is present in the structure of general intelligence. The other two TSIS Social information processing (SP) and Social Skills (SS) scales have minor correlation relationships with R. Amthauer Intelligence Test. The result shows the structural relationships between general intelligence with social intelligence.
The aim of the research is to identify and analyze the regular relationship between general intelligence (IQ) with social intelligence.

Results:
The correlational and factor analysis results established certain relationships in the factor-analytical structure of general intelligence with social intelligence. The correlation relationship of the social awareness subscale (SA) from the Social Intelligence Scale (TSIS) with individual subtests of the R. Amthauer Intelligence Structure Test was revealed.

Conclusion:
Our study established a statistically significant relationship at the significance level of 0.05 between IQ and social intelligence, particularly social consciousness (understanding), which allowed us to connect social intelligence and general (psychometric) intelligence.
Care Continuity, Telehealth Use, and Quality of Diabetes and Hypertension Care in Community Health Centers Before and During the COVID-19 Pandemic: Repeated Cross-sectional Study
Authors: Tierney Aaron Alexander , Payán Denise D , Brown Timothy , Aguilera Adrian , Shortell Stephen M , Rodriguez Hector P 
Published: January 2023

Background
Community health centers (CHCs) pivoted to remote chronic care services during the COVID-19 pandemic. While care continuity is associated with improved care quality and patients’ experiences, telehealth’s impact on these relationships is unclear.

Objective
We aimed to examine the association among care continuity, telehealth use, and quality of diabetes or hypertension care in CHCs before and during the COVID-19 pandemic.

Methods
We collected electronic health record data from a cohort of 20,792 patients with diabetes or hypertension with ≥2 visits per year from March to December 2019 and 2020 among 166 California CHCs in the OCHIN Accelerating Data Value Across a National Community Health Center Network Collaborative. Logistic regression models estimated the association between care continuity (modified, modified continuity index [MMCI]) and telehealth adoption and blood pressure or hemoglobin A1c (HbA1c) testing. Generalized linear regression models for 2019 and 2020 estimated the association between MMCI and blood pressure or HbA1c, exploring telehealth as a mediator.

Results
Patients experienced reduced care continuity (2019: MMCI=0.71, SD 0.28; 2020: MMCI=0.63, SD 0.36; P<.001) and more blood pressure (99.99% vs 99.75%) and HbA1c (53.38% vs 48.99%) assessments in 2019 vs 2020. Telehealth accounted for 0.33% of 2019’s visits and 9.55% of 2020’s visits. MMCI scores were associated with higher odds of telehealth use in 2020 (odds ratio [OR] 1.96; P<.001). MMCI (2019: OR 1.72, P<.001; 2020: OR 1.66, P<.001) and telehealth use (2019: OR 2.44, P<.001; 2020: OR 6.82, P<.001) were associated with greater HbA1c testing. MMCI was associated with lower HbA1c values in 2020 (–0.40, P=.01) and lower systolic (2019: –1.64, P=.045; 2020: –2.40, P=.001) and diastolic (2019: –1.24, P=.007; 2020: –1.33, P=.001) blood pressure. MMCI and telehealth were not associated with HbA1c values in 2019. In 2020, telehealth mediated the relationship between MMCI and HbA1c testing (percent mediated 59%), but not between MMCI and other study outcomes.

Conclusions
Care continuity facilitates telehealth use and enables resilient performance on process measures. Elucidating how care continuity influences telehealth adoption may provide insights about implementing patient-centered innovations.
Integrated Personal Health Record in Indonesia: Design Science Research Study
Authors: Harahap Nabila Clydea , Handayani Putu Wuri , Hidayanto Achmad Nizar 
Published: January 2023

Background
Personal health records (PHRs) are consumer-centric tools designed to facilitate the tracking, management, and sharing of personal health information. PHR research has mainly been conducted in high-income countries rather than in low- and middle-income countries. Moreover, previous studies that proposed PHR design in low- and middle-income countries did not describe integration with other systems, or there was no stakeholder involvement in exploring PHR requirements.

Objective
This study developed an integrated PHR architecture and prototype in Indonesia using design science research. We conducted the research in Indonesia, a low- to middle-income country with the largest population in Southeast Asia and a tiered health system.

Methods
This study followed the design science research guidelines. The requirements were identified through interviews with 37 respondents from health organizations and a questionnaire with 1012 patients. Afterward, the proposed architecture and prototype were evaluated via interviews with 6 IT or eHealth experts.

Results
The architecture design refers to The Open Group Architecture Framework version 9.2 and comprises 5 components: architecture vision, business architecture, application architecture, data architecture, and technology architecture. We developed a high-fidelity prototype for patients and physicians. In the evaluation, improvements were made to add the stakeholders and the required functionality to the PHR and add the necessary information to the functions that were developed in the prototype.

Conclusions
We used design science to illustrate PHR integration in Indonesia, which involves related stakeholders in requirement gathering and evaluation. We developed architecture and application prototypes based on health systems in Indonesia, which comprise routine health services, including disease treatment and health examinations, as well as promotive and preventive health efforts.
Team-Based Coaching Intervention to Improve Contrast-Associated Acute Kidney Injury
Authors: Brown Jeremiah R. , Solomon Richard , Stabler Meagan E. , Davis Sharon , Carpenter-Song Elizabeth , Zubkoff Lisa , Westerman Dax M. , Dorn Chad , Cox Kevin C. , Minter Freneka , Jneid Hani , Currier Jesse W. , Athar S. Ahmed , Girotra Saket , Leung Calvin , Helton Thomas J. , Agarwal Ajay , Vidovich Mladen I. , Plomondon Mary E. , Waldo Stephen W. , Aschbrenner Kelly A. , O'Malley A. James , Matheny Michael E. 
Published: January 2023

Background
Up to 14% of patients in the United States undergoing cardiac catheterization each year experience AKI. Consistent use of risk minimization preventive strategies may improve outcomes. We hypothesized that team-based coaching in a Virtual Learning Collaborative (Collaborative) would reduce postprocedural AKI compared with Technical Assistance (Assistance), both with and without Automated Surveillance Reporting (Surveillance).

Methods
The IMPROVE AKI trial was a 2×2 factorial cluster-randomized trial across 20 Veterans Affairs medical centers (VAMCs). Participating VAMCs received Assistance, Assistance with Surveillance, Collaborative, or Collaborative with Surveillance for 18 months to implement AKI prevention strategies. The Assistance and Collaborative approaches promoted hydration and limited NPO and contrast dye dosing. We fit logistic regression models for AKI with site-level random effects accounting for the clustering of patients within medical centers with a prespecified interest in exploring differences across the four intervention arms.

Results
Among VAMCs' 4517 patients, 510 experienced AKI (235 AKI events among 1314 patients with preexisting CKD). AKI events in each intervention cluster were 110 (13%) in Assistance, 122 (11%) in Assistance with Surveillance, 190 (13%) in Collaborative, and 88 (8%) in Collaborative with Surveillance. Compared with sites receiving Assistance alone, case-mix–adjusted differences in AKI event proportions were −3% (95% confidence interval [CI], −4 to −3) for Assistance with Surveillance, −3% (95% CI, −3 to −2) for Collaborative, and −5% (95% CI, −6 to −5) for Collaborative with Surveillance. The Collaborative with Surveillance intervention cluster had a substantial 46% reduction in AKI compared with Assistance alone (adjusted odds ratio=0.54; 0.40–0.74).

Conclusions
This implementation trial estimates that the combination of Collaborative with Surveillance reduced the odds of AKI by 46% at VAMCs and is suggestive of a reduction among patients with CKD.

Clinical Trial registry name and registration number:
IMPROVE AKI Cluster-Randomized Trial (IMPROVE-AKI), NCT03556293
Efficacy of dapagliflozin by baseline diabetes medications: A prespecified analysis from the DAPA-CKD study
Authors: Beernink Jelle M , Persson Frederik , Jongs Niels , Laverman Gozewijn D. , Chertow Glenn M. , McMurray John J. V. , Langkilde Anna Maria , Correa-Rotter Ricardo , Rossing Peter , Sjöström David , Toto Robert D. , Wheeler David C. , Heerspink Hiddo J.L. 
Published: January 2023

<p> </p>
<p><strong>Objective:</strong> To determine whether the benefits of dapagliflozin in patients with type 2 diabetes and chronic kidney disease (CKD) in the Dapagliflozin And Prevention of Adverse Outcomes in CKD trial (DAPA-CKD) varied by background glucose-lowering therapy (GLT).</p>
<p><strong>Research Design and Methods:</strong> We randomized 4304 adults (including 2906 with type 2 diabetes) with baseline eGFR 25–75 mL/min/1.73m2 and urinary albumin:creatinine ratio 200–5000 mg/g to dapagliflozin 10mg or placebo once daily (NCT03036150). The primary endpoint was a composite of ≥50% eGFR decline, end-stage kidney disease, and kidney or cardiovascular death. Secondary endpoints included a kidney composite endpoint (primary composite endpoint without cardiovascular death), a cardiovascular composite endpoint (hospitalized heart failure or cardiovascular death), and all-cause mortality. In this prespecified analysis, we investigated the effects of dapagliflozin on these and other outcomes according to baseline GLT class or number of GLTs.</p>
<p><strong>Results:</strong> The effects of dapagliflozin on the primary composite outcome was consistent across GLT classes and according to the number of GLTs (all interaction <em>P</em> >0.08). Similarly, we found consistent benefit of dapagliflozin compared to placebo on the secondary endpoints regardless of background GLT class or number of GLTs. The same applied to the rate of decline in estimated glomerular filtration rate and safety endpoints. Dapagliflozin reduced the initiation of insulin therapy during follow-up compared to placebo (HR 0.72 (0.54–0.96), P=0.025).</p>
<p><strong>Conclusion:</strong> Dapagliflozin reduced kidney and cardiovascular events in patients with type 2 diabetes and CKD across baseline GLT class or classes in combination.</p>
Politica e Santitá nel Pensiero di Igino Giordani
Authors: Matiello Suzana Terezinha , Wolff Elias 
Published: January 2023

Nella prospettiva dell’intimo legame tra cristologia e antropologia abbiamo scelto come argomento per la nostra ricerca lo studio della figura di Igino Giordani. Vissuto prima e dopo il Concilio Vaticano II, Giordani è stato un grande protagonista di questo periodo carico di tensioni e trasformazioni sociali, culturali e religiose e ha apportato un grande contributo alla società italiana e oltre mettendo, da cristiano, al centro del suo agire Cristo. L’obiettivo di questo articolo é quello di offrire, tramite alcuni scritti di Giordani, una riflessione sul momento storico che stiamo vivendo, caratterizzato anch’esso da una profonda crisi antropologica e spirituale. La metodologia aplicata in questa ricerca é quella di una analisi su alcuni texti di Igino Giordani. Nella prima parte della ricerca ci dedicheremo al incontro di Igino Giordani, nel 1948, con Chiara Lubich, fondatrice del Movimento dei Focolari e all’influenza che esso determina nella successiva fase della sua vita. Nella seconda parte riporteremo alcuni scritti dello stesso Igino Giordani dai quali si può cogliere lo spessore del suo essere cristiano in ogni ambito della vita sociale e politica. Nella terza parte parlaremo della politica e la morale nella prospettiva di Igino Giordani.
Buprenorphine has a concentration-dependent cytotoxic effect on equine chondrocytes in vitro
Authors: Castro-Cuellar Gabriel , Cremer Jeannette , Liu Chin-Chi , Queiroz-Williams Patricia , Hampton Chiara , Leise Britta Sigrid 
Published: January 2023

Abstract

OBJECTIVE
To investigate the cytotoxic effects of 2 different concentrations of buprenorphine and compare them with bupivacaine and morphine on healthy equine chondrocytes in vitro.

SAMPLE
Primary cultured equine articular chondrocytes from 3 healthy adult horses.

PROCEDURES
Chondrocytes were exposed for 0 and 2 hours to the following treatments: media (CON; negative control); bupivacaine at 2.2 mg/mL (BUPI; positive control); morphine at 2.85 mg/mL (MOR); buprenorphine at 0.12 mg/mL (HBUPRE); or buprenorphine at 0.05 mg/mL (LBUPRE). Chondrocyte viability was assessed using live/dead staining, water-soluble tetrazolium salt-8 (WST-8) cytotoxic assay, LDH assay, and flow cytometry. All continuous variables were evaluated with a mixed ANOVA with treatment, time, and their interactions as the fixed effects and each horse as the random effect.

RESULTS
Buprenorphine showed a concentration-dependent chondrotoxic effect. The viability of chondrocytes was significantly decreased with exposure to HBUPRE and BUPI compared to CON, MOR, and LBUPRE.

CLINICAL RELEVANCE
Negligible chondrotoxic effects were observed in healthy cultured equine chondrocytes exposed to 0.05 mg/mL of buprenorphine, whereas higher concentrations (0.12 mg/mL) showed a marked cytotoxic effect. Based on these results, low concentrations of buprenorphine appear to be safe for intra-articular administration. Further evaluation of this dose in vivo is needed before recommending its clinical use.
Contribution of G.I.S and Remote Sensing for the Risk Mapping of Soil Water Erosion at Saida Province (Western of Algeria)
Authors: Aouadj Sid Ahmed , Degdag Hanane , Hasaoui Okkacha , Nasrallah Yahia , Zouidi Mohamed , Allam Ayoub , Belkacm Nouar , Khatir Hadj 
Published: January 2023

Abstract
Soil water erosion is a major aspect of landscape degradation in sub-wet to semi-arid Mediterranean environments. This problem has not been dealt with in detail in Algeria although it affects large areas. The objective of this study is to develop a methodology using remote sensing, the digital terrain model (DTM) and geographic information systems (GIS) to map areas with a risk of water erosion within the territory of Saida province and to produce a risk map that can be used as a reference document by the local authority. The presented methodology consists to incorporate three factors controlling the erosion: slope, material friability and land use. The resulting erosion risk map shows five areas of vulnerability to water erosion: very low, low, moderate, high and very high. Areas with high and very high risk of erosion cover more than 20% of the mountainous area and are consistent with our field observations. The methodology presented in this study can be generalized to all areas of the foothills of the Tellian Atlas, where erosion risks pose a threat to urban areas. This model is a tool to help implement a soil conservation plan in order to organise the measures to be applied and ensure sustainable soil management.
Two generalizations of dual-complex Lucas-balancing numbers
Authors: Bród Dorota , Szynal-Liana Anetta , Włoch Iwona 
Published: January 2023

AbstractIn this paper, we study two generalizations of dual-complex Lucas-balancing numbers: dual-complex k-Lucas balancing numbers and dual-complex k-Lucas-balancing numbers. We give some of their properties, among others the Binet formula, Catalan, Cassini, d’Ocagne identities.
A short note on Layman permutations
Authors: Hajnal Péter 
Published: January 2023

Abstract
A permutation p of [k] = {1, 2, 3, …, k} is called Layman permutation iff i + p(i) is a Fibonacci number for 1 ≤ i ≤ k. This concept is introduced by Layman in the A097082 entry of the Encyclopedia of Integers Sequences, that is the number of Layman permutations of [n]. In this paper, we will study Layman permutations. We introduce the notion of the Fibonacci complement of a natural number, that plays a crucial role in our investigation. Using this notion we prove some results on the number of Layman permutations, related to a conjecture of Layman that is implicit in the A097083 entry of OEIS.