bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Dietary Factors in Acne Vulgaris among Young Adults: A Case–Control Study
Authors: Fernandes Michelle Serene , Pereira Pradeep 
Published: May 2023

Background:
Previous studies on the potential role of diet in acne vulgaris have shown conflicting results. However, there are very few studies from India.

Objective:
This study aims to evaluate the role of dietary factors in the causation of acne vulgaris among young adults.

Materials and Methods:
This case–control study studied the dietary factors of people aged 18–25 years. A total of 224 patients with moderate-to-severe acne were evaluated. The control group comprised 260 individuals with no or mild acne. Both groups were asked to fill up a questionnaire on sociodemographic characteristics, family history of acne among first-degree relatives, and relevant medical history. The information on selected food items such as milk and dairy products, rice, fruits, vegetables, fish, meat, chocolates, and cakes was recorded on a food frequency questionnaire. Frequency of intake was categorized as: More than 3 days/week, from 1 to 3 days/week, <1 day/week and never. Acne severity was determined as per a global score. Body mass index and other anthropometric measures were obtained.

Results:
There was a positive association of family history of acne with the occurrence of acne. Milk was highly significantly association with occurrence of acne (P = 0.000). The protective effect of fish consumption on acne was also noted.

Conclusion:
Clinicians need to counsel their patients regarding the effect of diet, especially dairy products on their acne lesions.
Etiological profile of seizure in children of age group 1 month to 18 years with special reference to neuroimaging in a tertiary care hospital
Authors: Mondal Bikram , Sarkar Oendrila , Halder Pankaj K. , Deb Sukanya , Guha Debasree , Mandal Amita S. 
Published: May 2023

Background:Seizure is a common cause of childhood hospitalization. Neuroimaging studies help in identifying etiologies, including the rare ones, and planning management.Purpose:The aim of this study is to determine the etiology of seizures in pediatric patients and the utility of neuroimaging in the same.Materials and Methods:A prospective study was carried out on 100 children who were admitted with seizures (including recurrent episodes) in our tertiary care institute. The sociodemographic profile, clinical features, neuroimaging findings, and findings of other investigations were documented and analyzed, to classify the type and etiology of seizures.Results:The male–female ratio among patients was 1.94: 1. Seizures of generalized onset were most common (95%), affecting mostly the age group of 1–5 years (50.53%), followed by the 5–18 years (29.47%) and the 1 month to 1 year (20%) groups. The etiologies were simple febrile seizure (51%), seizure disorder (8%), cerebral palsy (8%), acute viral meningoencephalitis (7%), pyogenic meningitis (6%), and complex febrile seizure (5%). Neuroimaging was carried out in 30 children, in which 14 showed abnormal reports, and abnormal electroencephalogram (EEG) report was found in 6 out of 10 patients. The analysis of the distribution of the types of seizures concerning age, gender, family history of seizure, history of seizure, socioeconomic status, and developmental milestones did not reveal any statistically significant relationships (P> 0.05).Conclusion:Seizure of generalized onset was the most common type, and the most common etiology was a simple febrile seizure. Abnormal neuroimaging/EEG findings were more pronounced in patients with focal seizures.
Evaluation of chemotherapeutic regimen and associated adverse drug reactions of colorectal cancer in a tertiary care hospital
Authors: Mol Linda S. , Jose Akash , Mohan Arathy , Madhu C. S. , Lakshmi R. 
Published: May 2023

Background:
Colorectal cancer (CRC) is the fourth most common cause of death diagnosed in both men and women. Though there are modifiable and non-modifiable risk factors for CRC. cancer patients encounter chemotherapy-associated drug interactions and adverse drug reactions hence the need for such a study will help the professionals to improve the patient’s quality of life.

Materials and Methods:
A six-month retrospective study of 130 patients who satisfied the inclusion and exclusion criteria was conducted by collecting data from November 2020 to May 2021. Data was collected from the Mediware system of the hospital using specially designed data collection forms.

Results:
Out of 130 patients, 61.51% were male and most of the patients were more than 60 years old. In this study, 11 patients had a history of smoking and alcoholism and 4% had a family history of CRC. Comorbidities associated with CRC were HTN and DM. In the study, stage 4 cancer patients were found to be more. 77.69% of patients had received chemotherapy along with surgery, and the most commonly prescribed regimen was Capcetabine and OxaliplatinThe length of hospital stay was increased for the FOLFOX (Oxaliplatin, 5-Fluorouracil, and Leucovorin) regimen. The common ADR analyzed was constipation, followed by vomiting and neutropenia, and most ADRs were associated with the CAPOX regimen (diarrhea) and treated accordingly.10 patients had febrile neutropenia, 5 patients had grade 4 neutropenia and all were treated with antibiotics and filgrastim. Febrile neutropenia was seen in patients with metastasis.

Conclusion:
Timely and appropriate treatment for ADRs and early screening can improve the quality of life of individuals. Further studies on this topic will help to improve the treatment quality provided by professionals
Comparison of onset of action of Intrathecal Clonidine vs Intrathecal Fentanyl as an adjuvant with hyperbaric Bupivacaine and Bupivacaine alone under spinal anesthesia for lower limb orthopedic surgeries
Authors: Devi Aradhana , Santosh Amrita , Har Archana , Vennel Jessy , Gadkari Vikrant 
Published: May 2023

Background:
Adjuvants are added to a local anesthetic solution to prolong the duration of analgesia. There is a paucity of studies comparing the onset of action of adjuvants like Clonidine and Fentanyl. In this study, the time of onset of action of intrathecal clonidine and intrathecal fentanyl as adjuvants to bupivacaine and bupivacaine alone were compared in the subarachnoid block for lower limb orthopedic surgeries.

Materials and Methods:
90 adult patients posted for orthopedic surgery of the lower limb were divided into three equal groups of 30 each. Group A being the control group was given hyperbaric Bupivacaine(3ml) +0.5ml of Normal saline, Group B was given Intrathecal hyperbaric Bupivacaine (3 ml) +30 μg Clonidine and Group C was given Intrathecal hyperbaric Bupivacaine (3 ml) + Fentanyl 25 μg. The primary objective was to compare the time of onset of block and duration of analgesia. The secondary outcomes were the duration of sensory and motor block, duration of analgesia, hemodynamic parameters, and side effects.

Results:
The time of onset of the sensory blockade was 4.83 ± 0.64, 1.72 ± 1.47, and 3.4 ± 1.43 mins in groups A, B, and C respectively. The time of onset of the motor blockade as estimated by the time to reach level 2 on the Bromage scale, was 6.07 ± 0.55, 2.38 ± 1.32, and 5.06 ± 1.28 mins in groups A, B, and C respectively. The duration of postoperative analgesia was prolonged in the Clonidine group compared to the Fentanyl group.

Conclusion:
The study reveals that the time of onset of action of sensory and motor block was faster and the duration of analgesia was prolonged with adjuvants like Clonidine when compared to Fentanyl when added to Bupivacaine.
Odontogenic tumors
Authors: Shinde Sumedha P. , Vatkar Arvind J. 
Published: May 2023

Introduction:
Odontogenic tumors (OTs) are rare and account for around 1% of jaw lesions including tumor and tumor-like lesions. OTs are a diverse category of lesions, displaying different inductive interactions. Although some are hamartomas, others are benign and malignant neoplasms with varying degrees of aggressiveness.

Materials and Methods:
We plan to review the histopathological aspects of OTs because of their diverse properties. At a tertiary medical and dental institute in Pune, India, we studied 28 cases of OTs over 2 years, from 2013 to 2015.

Results:
The most common forms of OTs were ameloblastoma (42.86%) and odontogenic keratocyst (21.15%). The highest number of OTs was found in the 21–30-year-old age group, with an even gender distribution.

Conclusion:
Ameloblastoma is the most common OT, accounting for roughly one-quarter of all jaw tumors. The majority of OTs occurs in young people aged 20–40 years. Fortunately, malignant OTs are extremely rare.
A prospective comparative study of concurrent chemoradiation in advanced carcinoma cervix patients with weekly cisplatin vs. weekly cisplatin and paclitaxel
Authors: Mukherjee Amit K. , Biswas Linkon , Bose Soumyo , Sharma Shyam , Mandal Srikrishna 
Published: May 2023

Background:
Cisplatin-based concurrent chemoradiation is the standard treatment for carcinoma cervix. However, there is a need to explore alternative chemotherapeutic agents to further improve the treatment outcome. In this study, weekly paclitaxel and cisplatin-based chemoradiation was compared with weekly cisplatin-based chemoradiation in terms of disease control and toxicity profile.

Materials and Methods:
Sixty-four patients with FIGO stage IB2-IIIB squamous cell carcinoma of the uterine cervix were divided (by simple random sampling) into two groups: control arm patients who received radiotherapy (50 Gy in 25 fractions over 5 weeks) with concurrent weekly cisplatin (40 mg/m2) and study arm patients received same radiation dose with weekly cisplatin (30 mg/m2) and paclitaxel (40 mg/m2). After that, all patients received brachytherapy 21 Gy/three fractions, one fraction/week. All patients were followed up weekly during treatment, then 4–6 weeks after treatment completion, and thereafter monthly for at least 6 months.

Results:
The overall treatment response (complete+ partial response) was numerically higher in the cisplatin-containing control arm, but not significant (93% vs. 80%, P-value = 0.406). High-grade early rectal (60% vs. 25%, P-value = 0.014) and acute gastrointestinal toxicity (66% vs. 6%, P-value <0.001) were significantly higher in the cisplatin and paclitaxel-containing arm. Hematological, renal, late rectal, and bladder toxicities were also numerically higher in the study arm, but not statistically significant.

Conclusion:
There was no significant benefit of weekly paclitaxel and cisplatin as an alternative to weekly cisplatin-based chemoradiation in the treatment of carcinoma cervix.
Physical, emotional, and social well-being and toxicity assessment in post-mastectomy female breast carcinoma patients undergoing adjuvant treatment
Authors: Mallick Swapan K. , Nahid Gufran K. , Deb Asit R. 
Published: May 2023

Objective:
Breast carcinoma is one of the most common cancers in India. Breast cancer is usually associated with serious side effects due to the long-term treatment procedure. This study investigates how to improve the overall quality of life (QoL) of patients in physical, psychological, and social aspects.

Materials and Methods:
Records of patients attending the Radiotherapy Outpatient Department (OPD) from May 2019 to June 2021 were analyzed retrospectively. Records of several patients available in the department were reviewed by the census method, which is based on pre-decided inclusion and exclusion criteria.

Results:
Out of 105 patients included in the study, 38.1% (N=40) of the patients were graduates, and 30.5% (N=32) of the patients were illiterate; 54.3% (N=57) of the patients belong to rural areas. Only 24.8% (N=26) of the patients were employed and the remaining 75.2% (N=79) of the patients were unemployed. However, most of the patients (41.0%) developed grade 1 acute skin toxicity, among which a maximum number of patients (N=47) developed grade1 late skin toxicity. After radiotherapy among all included patients, almost 13.0% of the patients developed arm edema. According to the Hospital Anxiety and Depression Scale score, the maximum abnormal scores for depression were 60.0% (N=63) and for anxiety 59.0% (N= 62).

Conclusion:
This study emphasizes that older women and those from lower socio-economic strata tolerated chemotherapy and radiotherapy better. We can also conclude that improved QoL has been a major concern for breast cancer patients undergoing long-term treatment. In a post-treatment setting, serial evaluation of the QoL not only improves the treatment outcome but can also be a prognostic factor.
Principal component analysis of categorized parameters in periprocedural myocardial injury following percutaneous coronary intervention
Authors: Acharyya Malay , Mondal Tanushree 
Published: May 2023

Objective:
The elevation of troponin-T (Trop-T) or creatinine kinase myocardial isoform (CKMB) is very common during the percutaneous coronary intervention (PCI). A study was attempted to determine the correlation between elevated Trop-T or CKMB and the parameters of PCI by using multivariate analysis, especially principal component analysis (PCA).

Materials and Methods:
A prospective observational study was carried out among 100 patients who underwent PCI for stable coronary artery disease in which 31 and 37 patients were found to have elevated Trop-T and CKMB (>3 times) following PCI. The correlation was studied between Trop-T or CKMB (dependent variable) and different parameters, viz., total stent length (mm), fluoroscopy time (min), lesion strength, left ventricular (LV) function, procedural complications, type of lesions, vessels treated with drug eluting stent (DES), and major adverse cardiac events (MACE) as independent variables.

Results:
For Trop-T, the principal component (PC)-1 and PC-2 obtained 63.49% and 30.88% of the original variation. For PC-1 and PC-2, maximum positive loading was recorded for stent length followed by fluoroscopy time and for LV but negative loading for the type of lesion and type of stent (DES vs bare metal stent [BMS]). For CKMB, the PC-1 and PC-2 obtained 61.22% and 32.08% of the original variation. For PC-1 and PC-2, maximum positive loading was recorded for stent length and fluoroscopy time followed by vessel treated but negative loading for the type of stent and MACE, and maximum positive loading recorded for LV function but negative loading for the type of lesion.

Conclusion:
This study indicates which factors are most important in preventing periprocedural myocardial injury during PCI and may be a suitable tool to prevent myocardial injury and for subsequent less MACE and better patient outcomes.
Surveillance of venomous arthropods on a Nigerian Public University campus
Authors: Ogbusu Vivian Ogbusu, , Onyido Angus Ejidikeme , Okechukwu Chidiebere Emmanuel , Okwelogu Izunna Somadina 
Published: May 2023

Background:
Venomous arthropods are arthropod species that use toxins for defense and offense. The objective of this study was to assess the biodiversity and abundance of venomous arthropods on the premises of Nnamdi Azikiwe University (NAU), Awka, Nigeria.

Materials and Methods:
Pitfall traps, sticky, and bait traps, beating and knockdown, and active search and handpicking with forceps were the methods used to collect various arthropods on the university campus. The data collected during this study were analyzed using the statistical package for social sciences version 23.0.

Results:
A total of 1,070 venomous arthropods were collected from the study areas, and they belong to four classes, six orders, fourteen families, and twenty-two species of the phylum Arthropoda.

Conclusion:
This study demonstrates that venomous arthropods are widespread on the NAU, Awka campus. Regular fumigation of the university premises is important in preventing human injuries, and infectious diseases carried by some arthropods.
Assessment of glycated hemoglobin levels in non-diabetic subjects with recently diagnosed hypo and hyperthyroidism
Authors: Narayanan Sujesh K. , Pillai Renjith G. 
Published: May 2023

Background:
Thyroid disorders are highly prevalent in the general population and generally manifest as hypothyroidism or hyperthyroidism. Glycated hemoglobin (HbA1c) is commonly used for the assessment of the long-term glycemic status of diabetic patients. But the HbA1c concentration not only depends on prime glycemia but some other factors.

Aims and Objectives:
The objective of this study was to measure glycated hemoglobin and thyroid hormone levels and aimed to determine the effects of hypo and hyperthyroidism on glycated hemoglobin in non-diabetic patients.

Materials and Methods:
This case-control study was conducted on 70 euglycemic individuals each newly diagnosed with hypo and hyperthyroidism. Seventy age and gender-matched controls were recruited. Baseline HbA1c was estimated by high-performance liquid chromatography (HPLC) and thyroid status was measured by chemiluminescent immunoassay (CLIA) method in all cases and controls and then compared.

Results:
HbA1c values were found to be significantly higher in the hypothyroid group (P < 0.001), whereby its values in hyperthyroid subjects showed no significant difference from controls (P = 0.17). A positive correlation (r=0.67) exists between the levels of thyroid-stimulating hormone (TSH) and HbA1c in hypothyroid patients, but no significant correlation (r= -0.07) was observed for hyperthyroid subjects.

Conclusion:
HbA1c may not be a reliable indicator of glycemic status in patients with hypothyroidism, and so HbA1c results should be interpreted with caution in such patients.
Pendampingan Pastoral dengan Pendekatan Cognitive Behavioral Therapy (CBT) kepada Kelompok Remaja yang Kecanduan Internet
Authors: Hulu Frisca Sri Wulan , Simorangkir Jungjungan , Simamora May Rauli 
Published: May 2023

The purpose of this study was to provide pastoral assistance using the Cognitive Behavioral Therapy (CBT) Approach to a group of teenagers who are addicted to the internet at GKPI Pearaja Tarutung. The research methodology used is a qualitative method with a pastoral case study approach. In this study, mentoring was carried out for 5 GKPI Peraraja Tarutung youth who had the highest scores out of 13 teenagers who were internet addicted. Pastoral assistance with the CBT Approach using Self Management techniques is very suitable for dealing with cases of teenagers who are addicted to the internet. The findings of this study, adolescents who are addicted to the internet experience withdrawal symptoms when they do not play the internet (experiencing dysphoric), use the internet excessively, use the internet as a way to get rid of and escape from problems, are tempted to access the internet, and fail to stop/restrain internet use. (lack of self control). As the final result of this study, adolescents can manage themselves against internet use so that they can reduce and change their cognition and behavior due to their addiction to the internet for the better and more positive. AbstrakTujuan penelitian ini adalah untuk memberikan pendampingan pastoral dengan Pendekatan Cognitive Behavioral Therapy (CBT) kepada kelompok remaja yang kecanduan internet di GKPI Pearaja Tarutung. Metodologi penelitian yang digunakan adalah metode kualitatif dengan pendekatan metode studi kasus pastoral. Dalam penelitian ini pendampingan dilakukan kepada 5 remaja GKPI Peraraja Tarutung yang memiliki skor tertinggi dari 13 remaja yang termasuk kacanduan internet. Pendampingan pastoral dengan pendekatan CBT menggunakan teknik Self Management sangat cocok untuk menangani kasus remaja yang kecanduan internet. Temuan penelitian ini, remaja yang kecanduan internet mengalami gejala penarikan saat tidak bermain internet (mengalami dysphoric), menggunakan internet secara berlebihan, penggunaan internet sebagai cara untuk menghilangkan dan melarikan diri dari masalah, tergoda untuk mengakses internet, dan gagal untuk menghentikan/mengekang penggunaan internet (kurang kontrol diri). Sebagai hasil akhir dari penelitian ini remaja dapat mengelola dirinya terhadap penggunaan internet sehingga dapat menurunkan dan mengubah kognitif dan perilaku akibat kecanduannya dengan internet menjadi baik dan lebih positif.
Implementasi Filsafat Pragmatisme William James dalam Proses Pendidikan Agama Kristen
Authors: Heeng Go , Zega Yunardi Kristian , Pandie Remegises Danial Yohanis , Gea Kariaman 
Published: May 2023

The purpose of writing this article is to discuss William James's philosophy of pragmatism and its implementation in the process of Christian religious education. This paper refers to the framework of William James's philosophical theory and its urgency for education, specifically Christian religious education. James emphasizes the importance of the practical application of ideas and concepts, and that the value of an idea can be measured by its practical consequences in action. James also emphasized the importance of experience in the learning process, and that experience should be used as a starting point in achieving a deeper understanding. By using the literature study method, researchers found that William James' theory can be implemented in the process of Christian religious education because it provides learning experiences through values that are democratic, social and changes in learning patterns through learning methods, the role of the teacher, the role of students and the contextual curriculum. AbstrakTujuan penulisan artikel ini adalah membahas filsafat pragmatisme William James dan implementasinya dalam proses pendidikan agama Kristen. Tulisan ini mengacu pada kerangka teori filsafat William James dan urgensinya bagi pendidikan, secara khusus pendidikan agama Kristen. James menekankan pentingnya aplikasi praktis dari gagasan dan konsep, dan bahwa nilai dari sebuah gagasan dapat diukur oleh konsekuensi praktiknya dalam tindakan. James juga menekankan pentingnya pengalaman dalam proses pembelajaran, dan bahwa pengalaman harus dijadikan sebagai titik awal dalam mencapai pemahaman yang lebih dalam. Dengan menggunakan metode studi pustaka, peneliti menemukan bahwa teori William James dapat di implementasikan dalam proses pendidikan agama Kristen karena memberikan pengalaman belajar melalui nilai-nilai yang bersifat demokratis, sosial dan perubahan pola belajar melalui metode belajar, peran guru, peran siswa serta kurikulum kontekstual.