bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retracted Article: Public regulation effectiveness assessment of Russian regional labor markets using hierarchical clustering method
Authors: Gurieva Lira , Dzhioev Aleksandr 
Published: May 2023

It has been commonly decided to retract this article on the grounds that one of the authors, Lira Gurieva, has used material without due knowledge of all parties involved in the results obtained within this research article. The author apologizes for the inadvertent misappropriation of the data.
The Authors, the Publisher and Editor approved to the retraction.
Aktuelles zum adulten Still-Syndrom: Diagnose, Therapiekonzepte und Leitlinie
Authors: Vordenbäumen Stefan , Feist Eugen 
Published: May 2023

Was ist neu?
Epidemiologie Das Still-Syndrom kann sich vom Kindes- bis ins höhere Erwachsenenalter manifestieren – mit jeweils leicht unterschiedlicher klinischer Ausprägung.
Pathogenese Das Still-Syndrom ist eine autoinflammatorische Erkrankung unklarer Ätiologie, bei der pathogenetisch das angeborene Immunsystem in Form einer Aktivierung von neutrophilen Granulozyten mit Freisetzung von pro-inflammatorischen Zytokinen IL1, -6, -18, und Typ-1-Interferonen eine zentrale Rolle einnehmen.
Diagnose und Differenzialdiagnose In der kürzlich erschienenen DGRh-S2e-Leitlinie zum adulten Still-Syndrom (AOSD) wird empfohlen, die Diagnose anhand der charakteristischen Symptomkonstellation aus u.a. intermittierendem Fieber, Exanthem, Arthralgien/Arthritis nach Ausschluss von Infektionen, Neoplasien und anderen rheumatologischen Erkrankungen zu stellen. Die Erfüllung der Yamaguchi-Klassifikationskriterien kann hierbei die Diagnose unterstützen.
Komplikationen Relevante Komplikationen mit Verschlechterung der Prognose sind insbesondere eine Perimyokarditis, eine vielgestaltige Lungenbeteiligung und das Makrophagenaktivierungssyndrom (MAS, auch als sekundäre hämophagozytische Lymphohistiozytose [HLH] bezeichnet). Beim MAS-HLH kommt es zum Zytokinsturm und zu einer Multiorganbeteiligung mit Zytopenien.
Therapie Nach klinischer Aktivitätseinschätzung wird eine Therapie mit Glukokortikoiden und Methotrexat oder Ciclosporin, bei höherer Aktivität auch mit dem IL1-Rezeptorantagonisten Anakinra, dem IL1β-Antikörper Canakinumab oder dem IL6-Rezeptorantikörper Tocilizumab empfohlen. Bei hoher Krankheitsaktivität kann gemäß den Leitlinien auch eine primäre Therapie mit Anakinra oder Canakinumab erfolgen. Die Zulassungssituation ist hierbei jeweils zu beachten. Therapeutisch sind in der vital bedrohlichen Situation eines MAS-HLH neben supportiven Intensivmaßnahmen der Einsatz hochdosierter Glukokortikoide, in Kombination mit den genannten Biologika, und ggf. auch Etoposid-haltige Therapieregime in Anlehnung an die Behandlungsempfehlungen anderer HLH-Erkrankungen notwendig.
Ultrafiltration bei kardiorenalem Syndrom
Authors: Schanz Moritz , Latus Jörg 
Published: May 2023

ZUSAMMENFASSUNGDas kardiorenale Syndrom (KRS) umfasst heterogene Erkrankungen von Herz und Niere, die im Wesentlichen durch eine wechselseitige Funktionsstörung von Herz und Nieren gekennzeichnet sind. Das häufig führende Symptom ist die Überwässerung, für die therapeutisch neben der klassischen diuretischen Behandlung auch interventionelle Verfahren zur Verfügung stehen. Die konservativen Therapiemöglichkeiten geraten gerade bei eingeschränkter Nierenfunktion oftmals an ihre Grenzen – trotz neuerer Kombinationstherapien zur Steigerung der diuretischen Effektivität mit SGLT2-Inhibitoren (SGLT2: „sodium glucose linked transporter 2“) oder Carboanhydrasehemmern. Interventionelle Verfahren kommen bei therapierefraktärer Herzinsuffizienz daher entweder zur isolierten Ultrafiltration bei alleiniger Volumenüberladung oder zur Nierenersatztherapie mittels Hämo- oder Peritonealdialyse zum Einsatz. Bei letzterer ist die Peritonealdialyse als besonders vorteilhaft hervorzuheben aufgrund der kontinuierlichen Ultrafiltration mit einer höheren hämodynamischen Stabilität, positiven kardialen Effekten und einer hohen Patientenautonomie.
Direct Fluoroalkylthiolation Based on Fluoroalkanesulfite Derivatives
Authors: Yi Wenbin , Wei Jingjing , Liang Shuaishuai , Jiang Lvqi 
Published: May 2023

AbstractFluoroalkylthio groups have received substantial attention in the past decade because of their unique physicochemical characteristics, and methods for incorporating these substituents into organic molecules have been rapidly developed in recent years. This account summarizes our efforts on the development of direct fluoroalkylthiolation with fluoroalkanesulfite derivatives. Several innovative and efficient strategies for the fluoroalkylthiolation of various substrates are disclosed, leading to various valuable fluoroalkylthiolated compounds in good yields.1	Introduction2	Fluoroalkylthiolation with Sodium Fluoroalkanesulfinate3	Fluoroalkylthiolation with Fluoroalkanesulfonyl Chloride4	Fluoroalkylthiolation with Other Fluoroalkanesulfite Derivatives5	Conclusion
Identifying the risk factors for intracranial herniation in patients with cerebral venous thrombosis
Authors: Dinç Yasemin , Ozpar Rıfat , Hakyemez Bahattin , Bakar Mustafa 
Published: May 2023

AbstractBackground Cerebral venous sinus thrombosis (CVST) is not as well understood as an ischemic stroke of arterial origin. Although the prognosis of CVST is usually good, parenchymal lesions may occur in some patients, and the development of intracranial herniation may result in death. For this reason, recognizing the risk factors for intracranial herniation and accurately determining those patients who should undergo decompressive craniectomy is important.Objective This study aims to determine the risk factors for intracranial herniation in patients with CVST.Methods A total of 177 patients diagnosed with CVST between 2015 and 2021 in our tertiary center were retrospectively included in this study.Results Of the 177 patients, 124 were female and 53 were male with mean ages of 40.65 ± 13.23 and 44.13 ± 17.09, respectively. Among those, 18 patients had developed intracranial herniation. A significant statistical relationship was observed between superior sagittal sinus thrombosis, sinus rectus thrombosis, venous collateral score, nonhemorrhagic venous infarct, presence of malignancy, small juxtacortical hemorrhage, and cortical vein thrombosis. The binary logistic regression analysis results showed that the most significant variables were the venous collateral score of 0, malignancy, and small juxtacortical hemorrhages.Conclusion This study identified small juxtacortical hemorrhages, the presence of malignancy, and a venous collateral score of 0 to be independent risk factors for intracranial herniation in CVST patients. Drawing on these results, we recommend close clinical observation of CVST patients, as they may be candidates for decompressive craniectomy.
Telehealth for amyotrophic lateral sclerosis in a multidisciplinary service in a Brazilian reference center
Authors: Fidelix Emanuela Coriolano , Santana Glauciane Costa , Barros Daniele Montenegro da Silva , Dourado Junior Mário Emílio Teixeira 
Published: May 2023

Abstract
Background Telehealth has been used in the treatment of different diseases, and it has been shown to provide benefits for patients with amyotrophic lateral sclerosis (ALS). Due to the social distancing measures put into effect during the coronavirus disease 2019 (COVID-19) pandemic, there was an urgent need for telehealth to ensure the provision of healthcare.
Objective To evaluate the feasibility of telehealth for the provision of multidisciplinary ALS care, and to assess its acceptability among patients and caregivers.
Methods We conducted a retrospective cohort study in which multidisciplinary evaluations were performed using the Teleconsulta platform. The patients included had ALS and at least one in-person clinical evaluation. The patients and the caregivers answered satisfaction questionnaires.
Results The sample was composed of 46 patients, 32 male and 14 female subjects. The average distance from their residences to the reference services was of 115 km. Respiratory adjustment was the most addressed topic.
Conclusion The strategy is viable and well accepted in terms of satisfaction. It was even more positive for patients in advanced stages of the disease or for those living far from the referral center.
Feasibility for evaluating motor aspects of Parkinson's disease through video consultations in a resource-limited setting in Southern Brazil
Authors: Teixeira-dos-Santos Daniel , Camelo Daniel Monte Freire , Strelow Matheus Zschornack , Silva Maysa Tayane Santos , Führ Paula , Marins Letícia Winer , Schumacher Schuh Artur Francisco 
Published: May 2023

Abstract
Background Performing motor evaluations using videoconferencing for patients with Parkinson's disease (PD) is safe and feasible. However, the feasibility of these evaluations is not adequately studied in resource-limited settings.
Objective To evaluate the feasibility of performing motor evaluations for patients with PD in a resource-limited setting.
Methods The examiners rated motor aspects of parkinsonism of 34 patients with PD from the Brazilian public healthcare system through telemedicine with the patient's own means by using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) rating scale. Quality measures of the video meeting were also obtained. The feasibility of rating the motor aspects was the primary outcome whereas the rating of individual motor aspects, video meeting quality and predictors of a complete evaluation served as secondary outcomes.
Results The least assessable parameters were freezing of gait (52.9%), gait (70.6%), leg agility, and rest tremor (both 76.5%). Complete MDS-UPDRS part III was possible in 41.2% of patients and 62 out of 374 motor aspects evaluated (16.6%) were missed. Available physical space for a video evaluation was the worst quality measure. Incomplete evaluations were directly associated with disability (p = 0.048, r = 0.34) and inversely with available physical space (p = 0.003, r = 0.55).
Conclusion A significant portion of the MDS-UPDRS part III is unable to be performed during telemedicine-based evaluations in a real-life scenario of a resource-limited setting.
Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis
Authors: Rocha Rebeka Bustamante , Bomtempo Fernanda Ferreira , Nager Gabriela Borges , Cenci Giulia Isadora , Telles João Paulo Mota 
Published: May 2023

Abstract
Background Several randomized clinical trials (RCTs) have shown that dual orexin receptor antagonists (DORAs) are effective in the treatment of chronic insomnia. However, the superiority of one particular DORA over the others remains unclear.
Objective To perform a network meta-analysis to evaluate the efficacy of different DORAs in patients with chronic insomnia.
Methods The Medline, Embase, and Cochrane Central databases were searched for RCTs that compared DORA with placebo in patients ≥ 18 years of age with a diagnosis of insomnia disorder. We pooled outcomes for wake time after sleep onset (WASO), latency to persistent sleep (LPS), total sleep time (TST), and adverse events (AEs).
Results We included 10 RCTs with 7,806 patients, 4,849 of whom received DORAs as the intervention. Overall, we found that DORAs were associated with the improvement of all analyzed efficacy outcomes. Concerning TST, an apparent dose-dependent pattern was noticed, with higher doses relating to a longer TST. Lemborexant 10mg provided the largest reduction in WASO (at month 1) in minutes (standardized mean difference [SMD] = -25.40; 95% confidence interval [95%CI] = -40.02–-10.78), followed by suvorexant 20/15mg (SMD = -25.29; 95%CI = -36.42–-14.15), which also appeared to provide the largest decrease in long-term WASO (SMD = -23.70; 95%CI = -35.89–-11.51). The most frequent AEs were somnolence, nasopharyngitis, and headache, with rates of up to 14.8%.
Conclusion Our results suggest that DORAs are associated with greater efficacy when compared with placebo in the treatment of insomnia, a complex 24-hour sleep disorder. Additionally, dosing might play an important role in the management of chronic insomnia.
Doxycycline to treat levodopa-induced dyskinesias in Parkinson's disease: a preliminary study
Authors: Santos-Lobato Bruno Lopes , Brito Manuelina Mariana Capellari Macruz , Pimentel Ângela Vieira , Cavalcanti Rômulo Torres Oliveira , Del-Bel Elaine , Tumas Vitor 
Published: May 2023

Abstract
Background Levodopa-induced dyskinesia (LID) is a common motor complication of levodopa therapy in patients with Parkinson's disease (PD). Doxycycline is a widely used and inexpensive tetracycline with anti-inflammatory properties.
Objective To evaluate the efficacy and safety of doxycycline in patients with PD and LID.
Methods This was an open-label, uncontrolled, single-arm, single-center, phase 2 proof-of-concept study in patients with PD with functional impact of dyskinesia, which used levodopa three times daily, in a movement disorders clinic in Brazil. Participants were treated with doxycycline 200 mg/day for 12 weeks, with evaluations at baseline, week 4, and week 12 of treatment. The primary outcome measure was the change from baseline in the Unified Dyskinesia Rating Scale (UDysRS) total score at week 12, evaluated by two blinded raters. Key secondary outcomes measures were OFF time and ON time with troublesome dyskinesia in the PD home diary.
Results Eight patients with PD were treated and evaluated. Doxycycline 200 mg/day reduced the UDysRS total score at week 12, compared with baseline (Friedman χ2 = 9.6; p = 0.008). Further, doxycycline reduced the ON time with troublesome dyskinesia (Friedman χ2 = 10.8; p = 0.004) without worsening parkinsonism. There were no severe adverse events, and dyspepsia was the commonest event.
Conclusion In this preliminary, open-label and uncontrolled trial, doxycycline was effective in reducing LID and safe after a 12-week treatment. Further well-designed placebo-controlled clinical trials with a longer duration and a larger number of participants are needed.
Clinical trial registration https://ensaiosclinicos.gov.br, identifier: RBR-1047fwbf
Glasgow coma scale pupil score (GCS-P) and the hospital mortality in severe traumatic brain injury: analysis of 1,066 Brazilian patients
Authors: Bertotti Melina Moré , Martins Evandro Tostes , Areas Fernando Zanela , Vascouto Helena Dresch , Rangel Norma Beatriz , Melo Hiago Murilo , Lin Katia , Kupek Emil , Pizzol Felipe Dal , Golby Alexandra J. , Walz Roger 
Published: May 2023

Abstract
Background Pupil reactivity and the Glasgow Coma Scale (GCS) score are the most clinically relevant information to predict the survival of traumatic brain injury (TBI) patients.
Objective We evaluated the accuracy of the GCS-Pupil score (GCS-P) as a prognostic index to predict hospital mortality in Brazilian patients with severe TBI and compare it with a model combining GCS and pupil response with additional clinical and radiological prognostic factors.
Methods Data from 1,066 patients with severe TBI from 5 prospective studies were analyzed. We determined the association between hospital mortality and the combination of GCS, pupil reactivity, age, glucose levels, cranial computed tomography (CT), or the GCS-P score by multivariate binary logistic regression.
Results Eighty-five percent (n = 908) of patients were men. The mean age was 35 years old, and the overall hospital mortality was 32.8%. The area under the receiver operating characteristic curve (AUROC) was 0.73 (0.70–0.77) for the model using the GCS-P score and 0.80 (0.77–0.83) for the model including clinical and radiological variables. The GCS-P score showed similar accuracy in predicting the mortality reported for the patients with severe TBI derived from the International Mission for Prognosis and Clinical Trials in TBI (IMPACT) and the Corticosteroid Randomization After Significant Head Injury (CRASH) studies.
Conclusion Our results support the external validation of the GCS-P to predict hospital mortality following a severe TBI. The predictive value of the GCS-P for long-term mortality, functional, and neuropsychiatric outcomes in Brazilian patients with mild, moderate, and severe TBI deserves further investigation.
Risk Factors of Venous Thromboembolic Disease in Cancer Patients Treated with Immune Checkpoint Inhibitor
Authors: le Sève Julien Denis , Guédon Alexis F. , Bordenave Stéphanie , Agard Christian , Connault Jérôme , Pistorius Marc-Antoine , Quéreux Gaelle , Espitia Olivier 
Published: May 2023

Background Immune checkpoint inhibitors (ICIs) have revolutionized the management of cancers. The risk factors and pathophysiological mechanisms of venous thromboembolic events (VTEs) of this new therapeutic class are still to be specified.
Methods The included patients had to have cancer and should be treated with ICI. Data analyzed included demographic data, biological data, and immune-related adverse events (IRAEs). We studied the prevalence of VTEs and the factors associated with VTEs.
Results Of 374 patients on ICI, over a median follow-up period of 15.2 months, the number of VTE was 50 (13.4%). The majority of patients were treated for metastatic melanoma or nonsmall cell lung cancer. There was no difference in prevalence or survival between cancer types. Patients with combined therapy composed of nivolumab and ipilimumab had higher 1-year cumulative VTE occurrence (29.3% [95% confidence interval [CI]: 9.7; 44.6]) than patients with pembrolizumab (14.9%, [95%CI: 2.5; 25.8], p = 0.03) or nivolumab (9.1%, [95% CI: 5.0; 12.9], p < 0.01). The presence of IRAE was associated with a higher risk of VTE occurrence compared with patients without any IRAE (1-year VTE cumulative incidence: 17.42% [95% CI: 9.5; 24.65] vs. 9.46% [95% CI: 5.18; 13.55], p = 0.04). There was a higher risk of VTE in patients treated with the combination of nivolumab and ipilimumab (adjusted subdistribution hazard ratio [SHR]: 3.71 [95% CI: 1.74; 7.90], p < 0.001) and in patients with IRAE (adjusted SHR: 2.14 [95% CI: 1.22; 3.75], p < 0.01).
Conclusion The prevalence of VTE was 14.2% under ICIs. IRAE and combine treatment of nivolumab and ipilimumab were associated with VTE. The pathophysiological mechanisms are multiple and complex with a possible link to aberrant activation of the immune system.
An analytical model of three-hot-wire acoustic particle velocity sensors
Authors: Zhu Zhezheng , Chen Wangnan , Yang Lingmeng , Gao Chengchen , Hao Yilong , Yang Zhenchuan 
Published: May 2023

Abstract
A thermal-based acoustic vector sensor consisting of three heated wires can detect acoustic particle velocity instead of pressure. This paper proposes an analytical model for calculating the temperature distribution and acoustic-caused temperature perturbation of the sensor with a three-hot-wire configuration. In this model, the nonlinear effect caused by non-uniform thermal conductivity is considered. The nonlinear effects will not only affect the temperature of the three hot wires, but also the frequency response of the sensor. Based on the stationary temperature distribution calculated by the nonlinear model, we correct the heat diffusion coefficient in the acoustic perturbation model. The nonlinear stationary model and the corrected perturbation model are found to be in good agreement with the numerical results. Furthermore, we design a chip to measure the temperature distribution of the three heated wires and compare the sensitivity of the sensor with the corrected model. The experimental results can verify the proposed model. This study provides a theoretical basis for sensor performance optimization.
Enhanced polarization conversion and giant Faraday rotation in patterned terahertz graphene metamaterials with combined electrical and magnetic tuning
Authors: Zhou Zesen , Gan Zhilong , Cao Lei 
Published: May 2023

Abstract
Graphene metamaterials (MMs) have the potential to reconfigure and dynamically control terahertz (THz) waves. In this study, we conducted numerical investigations to explore the effects of externally applied magnetic fields up to 20 Tesla on the transmission properties of graphene patterned split ring resonator (GSRR) MMs in the THz region. We quantitatively compared the tunability of resonance amplitude and frequency in the co-polarized transmission component between the magnetic method and the traditional electrical approach. Our results demonstrate that magnetic tuning can effectively modulate the resonant properties of GSRR MMs. Furthermore, when combining electrical and magnetic tuning, we observed an enhancement in the polarization conversion ratio, as well as the achievement of a significant Faraday rotation angle of nearly 90 degrees in GSRR MMs. These findings indicate the potential of functional graphene-based THz devices, including switches, modulators, polarization converters, and sensors.
Nanotechnology and enzyme immobilization: a review
Authors: Oke M A , Ojo S A , Fasiku S A , Adebayo E A 
Published: May 2023

Abstract
The synergy between enzymes and nanotechnology (nano-biocatalysts) has created some of the most promising biomaterials fabricated by synergistically incorporating advanced nano-biotechnology. The incorporation of enzymes into nanotechnology is of great significance for making nanomaterials that are rarely harmful to the environment. However, the unique/specific physicochemical characteristics and supramolecular nature ascribed to functional nanostructures (nanomaterials), have made them novel, interesting, and exceptional matrices for the creation of nano-biocatalysts. These have a lot of potential for improving the enzyme stability, function, efficiency, kinetic characteristics, vulnerability to diffusional constraints, and engineering performance in bioprocessing. Hence, the nano-biocatalysts developed contain exceptional properties with many potential applications in diverse fields. This review covers a wide range of the nanotechnology and enzyme technology involved in producing nano-biocatalysts, including different mechanisms, strategies in nanomaterial enzyme immobilization, and various nanocarriers, as well as recent developments in controlling enzyme activity. The vast range of potential applications of nano-biocatalysts in various fields, including food, pharmaceuticals, biofuels, and bioremediation, has been discussed.
Na and Cl co-doping modified LiNi0.5Co0.2Mn0.3O2 as cathode for lithium-ion battery
Authors: Song Liubin , Zheng Youhang , Kuang Yinjie , Zhao Tingting , Xia Yubo , Xiao Minzhi , Xiang Youtao , Xiao Zhongliang , Tang Fuli 
Published: May 2023

Abstract
In recent years, ternary nickel-rich layered oxides have gradually replaced traditional binary cathode materials in the lithium-ion battery market due to their advantages of high energy density and environmental protection. However, their structural instability of cathode materials has seriously affected the cycle performance of the battery. In order to optimize the internal structure of LiNi0.5Co0.2Mn0.3O2 (NCM523), the modified LiNi0.5Co0.2Mn0.3O2 was prepared by in situ doping Na and Cl wet grinding solid phase method. After 80 cycles at 1 C, the capacity retention rate was 80.91%, which was higher than that of LiNi0.5Co0.2Mn0.3O2 by 70.00%. Scanning electron microscopy showed that the surface corrosion of LiNi0.5Co0.2Mn0.3O2 was effectively alleviated by Na and Cl co-doping. In addition, the band structure, state density and volume changes were obtained by simulation. The results show that the impedance, capacity and capacity retention data are very compatible with the simulation results. Therefore, Na and Cl doping can effectively optimize the internal structure of LiNi0.5Co0.2Mn0.3O2 and improve its electrochemical performance. The combination of simulation and experiment provides a new approach for the modification of ternary cathode materials.