bluuebunny/crossref_metadata_2025_split huggingface dataset:
State-Level Indicators of Childhood Educational Quality and Incident Dementia in Older Black and White Adults
Authors: Soh Yenee , Whitmer Rachel A. , Mayeda Elizabeth Rose , Glymour M. Maria , Peterson Rachel L. , Eng Chloe W. , Quesenberry Charles P. , Manly Jennifer J. , Gilsanz Paola 
Published: February 2023

ImportanceHigher educational attainment is associated with reduced dementia risk, but the role of educational quality is understudied, presenting a major evidence gap, especially as it may contribute to racial inequities.ObjectiveTo evaluate the association between state-level educational quality during childhood and dementia risk.Design, Setting, and ParticipantsThis cohort study analyzed longitudinal data collected from January 1, 1997, through December 31, 2019 (23-year follow-up period). The sample comprised members of Kaiser Permanente Northern California (KPNC), a large integrated health care delivery system, who completed an optional survey during 1964-1972. Eligible individuals were US born; non-Hispanic Black or non-Hispanic White; aged 65 years or older as of January 1, 1996; were still alive; and did not have a dementia diagnosis or lapse in KPNC membership greater than 90 days between January 1 and December 31, 1996.ExposuresHistorical state-level administrative indicators of school quality (school term length, student-teacher ratio, and attendance rates) linked to participants using birth state and birth year (with a 6-year lag) and divided into tertiles using the pooled sample.Main Outcomes and MeasuresDementia diagnoses from electronic health records between 1997 and 2019 were analyzed between March 1 and August 31, 2022. The associations of educational quality with incident dementia were estimated using Cox proportional hazards regression models.ResultsAmong 21 450 KPNC members who participated in the optional survey, individuals born before availability of educational quality records (n = 87) and missing educational attainment (n = 585) were excluded. The final analytic sample was 20 778 individuals (56.5% women, 43.5% men; mean [SD] age, 74.7 [6.5] years; 18.8% Black; 81.2% White; 41.0% with less than high school education). Among Black individuals, 76.2% to 86.1% (vs 20.8%-23.3% of White individuals) attended schools in states in the lowest educational quality tertiles. Highest (vs lowest) educational quality tertiles were associated with lower dementia risk (student-teacher ratio: hazard ratio [HR], 0.88 [95% CI, 0.83-0.94]; attendance rates: HR, 0.80 [95% CI, 0.73-0.88]; term length: HR, 0.79 [95% CI, 0.73-0.86]). Effect estimates did not differ by race and were not attenuated by adjustment for educational attainment.Conclusions and RelevanceIn this cohort study, lower state-average educational quality was more common among Black individuals and associated with higher dementia risk. Differential investment in high-quality education due to structural racism may contribute to dementia disparities.
Faster and Protective Wound Healing Mechanistic of Para‐Coumaric Acid Loaded Liver ECM Scaffold Cross‐linked with Acellular Marine Kelp
Authors: Arin Asuva , Rahaman Md Sohanur , Farwa Ume , Lee Byong‐Taek 
Published: February 2023

AbstractDecellularized liver‐derived extracellular matrix is a unique combination of a complex milieu of growth factors and proteins that stimulate biochemical, physical, and mechanical cues to the cells. However, the lack of mechanical strength hindering the applicability of extracellular matrix (ECM) is an outstanding challenge. Herein, to deal with this problem, decellularized kelp is introduced as a crosslinking material thereby strengthening the physical structure of ECM for its utilization as a wound‐healing material. Consequently, a significant architectural change is observed in the ECM by forming a solid‐shaped scaffold. Nevertheless, the hindrance of high pH is addressed by incorporating the acidic drug p‐coumaric acid. To evaluate the innate regenerative abilities, the scaffolds are applied to rat excisional wounds. A remarkable wound healing capability is demonstrated by both the EK scaffolds, but a faster regeneration is achieved with only EK‐20@cou. The speculated hypothesis is that the incorporation of p‐coumaric acid can offer many additional bioactive benefits to the scaffold such as remarkable biocompatibility, antioxidant, and anti‐bacterial properties that are deliberately supported by the in vitro results. In silico molecular simulations (MS) validated that p‐Cou released from the EK‐20@Cou scaffold is accountable for the observed extraordinary regenerative behavior as compared to EK‐20(PW).
Highly Stretchable Electronic‐Skin Sensors with Porous Microstructure for Efficient Multimodal Sensing with Wearable Comfort
Authors: Zhang Xuanning , Li Jianwei , Lin Jun , Li Wen , Chu Wei , Zhang Mingming , Lu Yuyan , He Xinhai , Zhao Qiangli 
Published: February 2023

AbstractWearable electronic skins have aroused extensive interest in health detection, human–computer interaction, and robotics. However, it remains a great challenge to realize the multifunctional electronic skin with a wide detection range, high sensitivity, multi‐stimulus response, and wearable comfort on a single device. Here, a flexible porous thermoplastic polyurethane (TPU)/carbon black (CB) multimodal sensor that perceives multiple stimuli of pressure, strain, and humidity is prepared by the water vapor‐induced phase separation method. The as‐prepared device exhibits a wide pressure detection range (up to 49 kPa), excellent sensitivity (0.21 kPa−1), fast response (150 ms), and recovery time (120 ms). Furthermore, as a strain sensor, it is not only highly stretchable (730%), but also can operate over a strain range of 0–240% with a sensitivity of up to 1485.2 and excellent durability. Moreover, the designed sensor can detect humidity changes from 35% to 90% and has a fast response time (1.2 s), while enabling non‐contact sensing of a fingertip. Importantly, the porous TPU/CB film presents excellent breathability, enabling it to achieve a high level of comfort. Therefore, the perfect integration of these features ensures the potential applications of porous TPU/CB sensors in human activity detection, exhale monitoring, and breathable wearable devices.
An Efficient Fog Collector Achieved by Optimal Hierarchical Surface Patterns and Wetting Gradient
Authors: Wang Xiaobo , Guo Zhiguang , Liu Weimin 
Published: February 2023

AbstractWith the decrease in fresh water resources, fog collection has become a promising way to obtain fresh water. This paper presents an efficient fog collector that combines wettability and spokes geometry. Water droplets move along a fixed route on the mist collector and can easily overcome the pinning effect at the end of the structure to detach from the surface and then be collected. Its fog collecting efficiency can be 1.82 times that of a planar zinc sheet, which provides a new idea for the design of subsequent fog collectors.
Black Phosphorus‐Based Absorbing Bionic Stacked Structured Linear Polarization Detector
Authors: Zhang Ran , Duan Bin , Wang Ruofan , Fan Yuanyi , Chu Jinkui 
Published: February 2023

AbstractPolarization detection technology is developing toward miniaturization and high integration from the early time‐division type, amplitude‐division type, aperture‐division type, etc., to a more integrated focal plane‐integrated array type. Focal plane detectors that rely on metal nanogrids are not able to guarantee both temporal and spatial resolution for lossless polarized light detection with a guaranteed level of integration. Inspired by Agabus japonicus, the black phosphorus (BP)‐based absorbing bionic stacked structured linear polarization detector (BSLD) is proposed. The BSLD exploits the polarization absorption properties of BP to achieve near‐lossless linear polarization detection. The design includes two orthogonally aligned polarization‐ and angle‐sensitive BP photodetectors. The detection performance of the detector is investigated and analyzed under a green laser beam (wavelength 532 nm). The BSLD designed in this paper can simultaneously measure the multi‐angle component information of the incident light at one point in space in order to resolve the polarization state of the incident light, providing a potential solution for an integrated, real‐time, and high‐resolution loss‐free polarization image sensor.
Anisotropic Optical and Mechanical Properties in Few‐Layer GaPS4
Authors: Liu Shuai , Cui Xuwei , Zhang Qinghua , Shen Wanfu , Du JianTao , Lin Ting , Wang Yunkun , Wu Minghui , Gu Lin , Gao Yunan , Hu Chunguang , Liu Luqi , Yang Shengxue , Jiang Chengbao 
Published: February 2023

AbstractLow‐symmetry 2D materials have received tremendous attention due to their anisotropic optical, electrical, and mechanical properties and viable candidates for polarized photodetectors, anisotropic field‐effect transistors, and nanomechanical systems. Here, an interesting low‐symmetry 2D material (GaPS4) is reported and its in‐plane anisotropic structure, optical, and mechanical properties are investigated. The polarized Raman and absorption spectra prove the sensitivity of GaPS4 to crystalline orientation and linear dichroism. The experimental results of azimuth‐dependent reflectance difference microscopy can visually reveal the in‐plane optical anisotropy of GaPS4 flakes. Moreover, an interesting pressurized bubble method is designed to verify the anisotropic mechanical properties of GaPS4 flakes and saddle‐like bubble devices of GaPS4 are successfully fabricated. The saddle‐like bubble devices exhibit visual anisotropic deflection variations along the orthogonal direction. Kelvin probe force microscope enables the direct identifying of the surface potential distribution of bubble devices under strain. Interest would be excited in the anisotropic optical and mechanical properties and relevant device applications of low‐symmetry 2D materials.
Highly Efficient Blue Electro‐Fluorescence and Hybrid White Electroluminescence Basing on a Novel Hybrid Local and Charge‐Transfer (HLCT) Material with Weak Donor–Acceptor Structure and High Carrier Mobilities
Authors: Cui Wei , Liu Chaoke , Chao Xun , Xie Mingliang , Sun Qikun , Liu Danfeng , Pan Yuyu , Zhang Shi‐Tong , Xue Shanfeng , Yang Wenjun 
Published: February 2023

AbstractHigh efficiency and luminance are critical for commercialized blue organic light‐emitting diodes (OLEDs). Herein, a novel donor–acceptor (D–A) blue‐emissive molecule with a weak donor and acceptor is synthesized. The moderate hybrid local and charge transfer (HLCT) state character endows PPIBPO with blue fluorescence and high quantum efficiency. More importantly, the rigid, rod‐like molecular structure gives rise to the regularity of the stacking pattern of PPIBPO, which enables its extraordinary carrier mobilities in non‐doped OLED, the hole mobility and electron mobility are as high as 5.09 × 10−5 cm2 V−1 s−1 and 3.22 × 10−4 cm2 V−1 s−1, respectively. The non‐doped blue OLED of PPIBPO achieves a maximum external quantum efficiency (EQE) of 12.0% and a maximum luminance of 55023 cd m−2, which is one of the best values among the non‐doped blue OLEDs based on HLCT molecules. Furthermore, high‐efficiency two‐color hybrid warm white OLED with a maximum EQE up to 22.5% and maximum power efficiency of 87.0 lm W−1 is also achieved using PPIBPO as blue‐fluorophor.
EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1
Authors: Pan Yihui , Shu Guannan , Fu Liangmin , Huang Kangbo , Zhou Xinwei , Gui Chengpeng , Liu Huashan , Jin Xiaohan , Chen Minyu , Li Pengju , Cen Junjie , Feng Zihao , Lu Jun , Chen Zhenhua , Li Jiaying , Xu Quanhui , Wang Yinghan , Liang Hui , Wang Zhu , Deng Qiong , Chen Wei , Luo Junhang , Yang Jiefeng , Zhang Jiaxing , Wei Jinhuan 
Published: February 2023

AbstractHigh lymphocyte infiltration and immunosuppression characterize the tumor microenvironment (TME) in renal cell carcinoma (RCC). There is an urgent need to elucidate how tumor cells escape the immune attack and to develop novel therapeutic targets to enhance the efficacy of immune checkpoint blockade (ICB) in RCC. Overactivated IFN‐γ‐induced JAK/STAT signaling involves in such TME, but the underlying mechanisms remain elusive. Here, EH domain‐binding protein 1‐like protein 1 (EHBP1L1) is identified as a crucial mediator of IFN‐γ/JAK1/STAT1/PD‐L1 signaling in RCC. EHBP1L1 is highly expressed in RCC, and high EHBP1L1 expression levels are correlated with poor prognosis and resistance to ICB. EHBP1L1 depletion significantly inhibits tumor growth, which is attributed to enhanced CD8+ T cell‐mediated antitumor immunity. Mechanistically, EHBP1L1 interacts with and stabilizes JAK1. By competing with SOCS1, EHBP1L1 protects JAK1 from proteasomal degradation, which leads to elevated JAK1 protein levels and JAK1/STAT1/PD‐L1 signaling activity, thereby forming an immunosuppressive TME. Furthermore, the combination of EHBP1L1 inhibition and ICB reprograms the immunosuppressive TME and prevents tumor immune evasion, thus significantly reinforcing the therapeutic efficacy of ICB in RCC patient‐derived xenograft (PDX) models. These findings reveal the vital role of EHBP1L1 in immune evasion in RCC, which may be a potential complement for ICB therapy.
London Dispersion Effects in a Distannene/Tristannane Equilibrium: Energies of their Interconversion and the Suppression of the Monomeric Stannylene Intermediate
Authors: Zou Wenxing , Bursch Markus , Mears Kristian L. , Stennett Cary R. , Yu Ping , Fettinger James C. , Grimme Stefan , Power Philip P. 
Published: February 2023

AbstractReaction of {LiC6H2−2,4,6‐Cyp3⋅Et2O}2 (Cyp=cyclopentyl) (1) of the new dispersion energy donor (DED) ligand, 2,4,6‐triscyclopentylphenyl with SnCl2 afforded a mixture of the distannene {Sn(C6H2−2,4,6‐Cyp3)2}2 (2), and the cyclotristannane {Sn(C6H2−2,4,6‐Cyp3)2}3 (3). 2 is favored in solution at higher temperature (345 K or above) whereas 3 is preferred near 298 K. Van't Hoff analysis revealed the 3 to 2 conversion has a ΔH=33.36 kcal mol−1 and ΔS=0.102 kcal mol−1 K−1, which gives a ΔG300 K=+2.86 kcal mol−1, showing that the conversion of 3 to 2 is an endergonic process. Computational studies show that DED stabilization in 3 is −28.5 kcal mol−1 per {Sn(C6H2−2,4,6‐Cyp3)2 unit, which exceeds the DED energy in 2 of −16.3 kcal mol−1 per unit. The data clearly show that dispersion interactions are the main arbiter of the 3 to 2 equilibrium. Both 2 and 3 possess large dispersion stabilization energies which suppress monomer dissociation (supported by EDA results).
Effect of heat treatment on the performance of 3D printed thermoplastic polyurethane flexible substrates
Authors: Gu Sujuan , Ma Jing , Kang Luhan , Wei Hongtao , Jiang Lin , Wang Lixia 
Published: February 2023

Abstract3D printing technology combined with thermoplastic polyurethane (TPU) is increasingly being used in flexible electronics. However, the defects induced by 3D printing may degrade the mechanical properties of the TPU substrates significantly and result in the decrease in breaking elongation, tensile strength, and waterproof performance. In this article, we investigate the effect of heat treatment on improving the mechanical and waterproof properties of TPU substrate experimentally. The results show that heat treatment can effectively reduce the defects such as bubbles and pores inside the 3D printed TPU structure and increase the bonding area of the filament, and thus making the 3D printed TPU structure dense. After heat treatment at 180°C, the tensile strength and elongation at break of 3D printed TPU samples in the fiber direction (filling angle of 0°) increased by 67% and 38%, respectively. The tensile strength and elongation at break in the bonding direction (filling angle of 90°) increased by 100% and 75%. In addition, the waterproof performance of the samples has been enhanced, and the water contact angle of the surface has increased from 90.4°to 95.25°. Therefore, the heat treatment can effectively improve the mechanical properties and waterproof performance of 3D printed TPU samples.
Gas‐phase degradation of VOCs using supported bacteria biofilms
Authors: Xu Chao , Frigo‐Vaz Benjamin , Goering Joshua , Wang Ping 
Published: February 2023

AbstractHerein we report the use of Pseudomonas putida F1 biofilms grown on carbonized cellulosic fibers to achieve biodegradation of airborne volatile organic compounds (VOCs) in the absence of any bulk aqueous‐phase media. It is believed that direct exposure of gaseous VOC substrates to biomass may eliminate aqueous‐phase mass transfer resistance and facilitate VOC capture and degradation. When tested with toluene vapor as a model VOC, the supported biofilm could grow optimally at 300 p.p.m. toluene and 80% relative humidity, with a specific growth rate of 0.425 day−1. During long‐term VOC biodegradation tests in a tubular packed bed reactor, biofilms achieved a toluene degradation rate of 2.5 mg gDCW−1 h−1 during the initial growth phase. Interestingly, the P. putida F1 film kept biodegrading activity even at the stationary nongrowth phase. The supported biofilms with a biomass loading of 20% (wt) could degrade toluene at a rate of 1.9 mg gDCW−1 h−1 during the stationary phase, releasing CO2 at a rate of 6.4 mg gDCW−1 h−1 at the same time (indicating 100% conversion of substrate carbon to CO2). All of these observations promised a new type of “dry” biofilm reactors for efficient degradation of toxic VOCs without involving a large amount of water.
Multiple roles of released c‐type cytochromes in tuning electron transport and physiological status of Geobacter sulfurreducens
Authors: Liu Jia‐Qi , Ma Xin , Liu Dong‐Feng , Yang Chuan‐Wang , Li Dao‐Bo , Min Di , Yu Han‐Qing 
Published: February 2023

AbstractDissimilatory metal‐reducing bacteria (DMRB) can transfer electrons to extracellular insoluble electron acceptors and play important roles in geochemical cycling, biocorrosion, environmental remediation, and bioenergy generation. c‐type cytochromes (c‐Cyts) are synthesized by DMRB and usually transported to the cell surface to form modularized electron transport conduits through protein assembly, while some of them are released as extracellularly free‐moving electron carriers in growth to promote electron transport. However, the type of these released c‐Cyts, the timing of their release, and the functions they perform have not been unrevealed yet. In this work, after characterizing the types of c‐Cyts released by Geobacter sulfurreducens under a variety of cultivation conditions, we found that these c‐Cyts accumulated up to micromolar concentrations in the surrounding medium and conserved their chemical activities. Further studies demonstrated that the presence of c‐Cyts accelerated the process of microbial extracellular electron transfer and mediated long‐distance electron transfer. In particular, the presence of c‐Cyts promoted the microbial respiration and affected the physiological state of the microbial community. In addition, c‐Cyts were observed to be adsorbed on the surface of insoluble electron acceptors and modify electron acceptors. These results reveal the overlooked multiple roles of the released c‐Cyts in acting as public goods, delivering electrons, modifying electron acceptors, and even regulating bacterial community structure in natural and artificial environments.
Two New α‐Glucosidase Inhibitory Depsidones from the Lichen Parmotrema cristiferum (Taylor) Hale
Authors: Do Thanh‐Hung , Duong Thuc‐Huy , Nguyen Minh An Tran , Vo Thi‐Phi‐Giao , Do Van‐Mai , Nguyen Ngoc‐Hong , Sichaem Jirapast 
Published: February 2023

AbstractA bioactivity‐guided investigation of the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae) led to the isolation of two new depsidones, cristifones A and B (1 and 2). The structures of the isolated compounds were identified by spectroscopic methods and comparison with the literature data. Compound 1 showed the initial combined structures of depsidone and depside cores. The two isolated compounds were then evaluated for α‐glucosidase inhibition. Compounds 1 and 2 were confirmed as potent, with IC50 values of 21.5 and 18.4 μM, respectively. Compound 2 was a non‐competitive inhibitor against α‐glucosidase, as indicated by the intersect in the second quadrant of each respective plot.
Intracellular Delivery of mRNA for Cell‐Selective CRISPR/Cas9 Genome Editing using Lipid Nanoparticles
Authors: Ma Tianyu , Chen Xianghan , Wang Ming 
Published: February 2023

AbstractMessenger RNA (mRNA) is being used as part of an emerging class of biotherapeutics with great promise for preventing and treating a wide range of diseases, as well as encoding programmable nucleases for genome editing. However, mRNA's low stability and immunogenicity, as well as the impermeability of the cell membrane to mRNA greatly limit mRNA's potential for therapeutic use. Lipid nanoparticles (LNPs) are currently one of the most extensively studied nanocarriers for mRNA delivery and have recently been clinically approved for developing mRNA‐based vaccines to prevent COVID‐19. In this review, we summarize the latest advances in designing ionizable lipids and formulating LNPs for intracellular and tissue‐targeted mRNA delivery. Furthermore, we discuss the progress of intracellular mRNA delivery for spatiotemporally controlled CRISPR/Cas9 genome editing by using LNPs. Finally, we provide a perspective on the future of LNP‐based mRNA delivery for CRISPR/Cas9 genome editing and the treatment of genetic disorders.
Double spatial confinement on ruthenium nanoparticles inside carbon frameworks as durable catalysts for a quasi‐solid‐state Li–O2 battery
Authors: Wang Meiling , Yao Ying , Yang Feiyang , Tang Zhenwu , Ren Jingjie , Zhang Cunzhong , Wu Feng , Wang Xiangke 
Published: February 2023

AbstractThe rational design of large‐area exposure, nonagglomeration, and long‐range dispersion of metal nanoparticles (NPs) in the catalysts is critical for the development of energy storage and conversion systems. Little attention has been focused on modulating and developing catalyst interface contact engineering between a carbon substrate and dispersed metal. Here, a highly dispersed ultrafine ruthenium (Ru) NP strategy by double spatial confinement is proposed, that is, incorporating directed growth of metal–organic framework crystals into a bacterial cellulose templating substrate to integrate their respective merits as an excellent electrocatalytic cathode catalyst for a quasi‐solid‐state Li–O2 battery. The porous carbon matrix with highly dispersed ultrafine Ru NPs is well designed and used as cathode catalysts in a Li–O2 battery, demonstrating a high discharge areal capacity of 6.82 mAh cm–2 at 0.02 mA cm–2, a high‐rate capability of 4.93 mAh cm–2 at 0.2 mA cm–2, and stable discharge/charge cycling for up to 500 cycles (2000 h) with low overpotentials of ~1.4 V. This fundamental understanding of the structure–performance relationship demonstrates a new and promising approach to optimize highly efficient cathode catalysts for solid‐state Li–O2 batteries.