bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertainty Assessment in the Prediction of Selected Fission Products in the Case of a Postulated Severe Accident Scenario at VVER-1000
Authors: Groudev P. , Petrova P. , Vryashkova P. 
Published: September 2023

Abstract
The aim of the paper is to present the results and insights gained from the analysis of the postulated severe accident scenario for the Nuclear Power Plant (NPP) equipped with a VVER-1000, focusing on the uncertainty assessment in the prediction of selected Fission Products (FPs). To this end, the simulation of the Large Break Loss of Coolant Accident (LB LOCA) along with a Station Blackout (SBO) scenario was carried out. The capabilities of the ASTECv2.2.0.1 [1] severe accident (SA) code along with the uncertainty quantification tool – SUNSET [2] in the coupled mode was used. The analysis was carried out for the eight input variables and ten output variables. The uncertainty quantification method incorporated within the SUNSET statistical tool was used in order to conduct the present analysis. Based on the Wilks’ formula, the number of ASTEC code runs was determined. The main statistical data are obtained for the selected fission products as figures of merit. The main steps of the analysis are outlined. Furthermore, a brief overview of the SUNSET/ASTECv2.2.0.1 coupling procedures [3] is also presented and discussed. This work demonstrates the application of the uncertainty quantification methodology in the analyses of the severe accidents in the Nuclear Power Plants and provides the specific recommendations of its use. The main outcomes from the assessment provided will be useful and may be a base for the future analyses related to the evaluation of the safety of the VVER-1000.
Feasibility Study for Minor Actinides Transmutation in Conventional Power Reactors
Authors: Mitev M , Filipov K 
Published: September 2023

Abstract
The handling and storage of the spent fuel from the current nuclear power reactors is one of the major ecological challenges in front of the nuclear energy industry, due to its long period of high radiotoxicity. It is mainly caused by the long-lived minor actinides generated in the nuclear fuel. Therefore profound study of the possibilities for shortening the terms of storage of spent nuclear fuels and some of high radioactive waste through the currently available technologies is necessary. The possibility for transmutation of Neptunium, Americium and Curium isotopes, as most abundant in the spent nuclear fuel of the wide-spread Light Water Reactors is evaluated in the paper using one of the most recent tools, available for the purpose. The most technologically accessible option, the current nuclear power reactors is analysed. The fuel in the cores of the LWR (PWR) and the PHWR (CANDU) type of reactors are modelled and the variation of the quantity of Neptunium, Americium and Curium isotopes after typical fuel campaigns for these reactors is estimated. The obtained results show that under the investigated conditions both types of reactors show potential for decrease of the minor actinides quantity in spent fuel before its final disposal, therefore provide a vital option toward sustainable and environmentally friendly nuclear spent fuel management.
A study on the design and production of sustainable accessories for children’s clothing
Authors: Atanasova Radka , Ivanova Miroslava , Merkova Monika 
Published: September 2023

AbstractThe present study directs research and creative development towards the potential of producing sustainable accessories for children’s clothing. Proposed fashion collection consists of ten models of hood-scarf. Designed hood-scarfs are “sustainable”, because they have two “faces” and are able to be combined with jackets, sweaters, vests or sweatshirts to obtain a variety of different outfits, without having to buy a number of different clothes. This leads to reducing fabric consumption. The models consist of relatively small details so that residual/waste pieces of fabric can be used for their sewing. The accuracy of the fit of products is inspected with the help of 3D virtual clothing software. This eliminates the need to sew a physical fabric sample which again leads to resource saving. The use of 3D visualization of models saves time and manpower and thus increases production efficiency. Another ecological effect is achieved, because by means of the virtual sample, the purchase decision will be made before the real product is sewn and the percentage of unrealized production in the commercial network is greatly reduced.
Flood risk assessment in urban areas in Bulgaria
Authors: Velichkova Rositsa , Angelova Radostina , Simova Iskra , Gieva Elitsa 
Published: September 2023

Abstract
Flooding is a phenomenon that cannot be prevented. Some human activities, such as the growth of settlements and economic assets in the floodplains, as well as the declining natural capacity of the soil to retain water caused by land use and climate change, are key factors in increasing the likelihood of floods and their adverse effects. The study is based on the data published in the National Statistical Institute Annual Reports, aiming to analyse and summarise the cases of floods in the urban areas in Bulgaria. The flood risk in the country in the period 2007-2021 is assessed for the urban areas near 17 hydrometric stations (HS). The flood index K is used to determine the areas with the highest sensitivity to floods as well as to extreme floods with significant adverse effects. The results have shown that only particular areas occasionally show high sensitivity to floods. As an average, however, for the study period, there is no area (HS) with river basins that are very sensitive to floods (K≥0.3) for the investigated period (2007-2021). Seven of the nineteen HS are sensitive to floods: Glozhene (HS2), Targovishte (HS6), Varna (HS8), Sofia-Orlandovtsi (HS12), Yambol (HS15), Burgas (HS17) and Kardzhali (HS19).
State of the Art - Drones/Surface Platforms and Green Energy
Authors: Popa Nicolae-Silviu , Popescu Mihai-Octavian , Mocanu Vlad 
Published: September 2023

Abstract
This paper presents a summary of what surface drones mean and the possibility of using these platforms in pollution problems. Also, in this paper, the authors have proposed to predict (in the form of a review) the possibility of producing the electricity needed for these platforms with the help of photovoltaic panels and the storage of energy in different types of batteries. This paper is a summary of what drones/surface platforms entail, the production of electricity using photovoltaic panels and an overview of battery types.
Influence of geography and weather conditions on the navigation and seaborne trade in the Black Sea
Authors: Bosneagu Romeo , Lupu Sergiu , Scurtu Ionut Cristian , Lupu Carmen Elena , Patrau Daniel Daneci , Coca Carmen Elena 
Published: September 2023

Abstract
The navigation on the Black Sea raises some specific issues that need to be considered, to ensure maximum safety conditions for the ship, crew, and cargo throughout the voyage. Under the current conditions of the global maritime market having a high degree of concurrency, respectively the problem of reducing fuel consumption and reducing the time needed for performing various voyages, especially in crossing the ocean on different routes, is particularly important for ship owners. The economic effect is determined by converting this time into the corresponding cost price, fuel consumption having the main percentage; to these is added the benefits increase by reducing the period of undertaking the transport contract.
An interrupted time series study of electronic health record clinical decision support for providers caring for patients with atrial fibrillation at increased stroke risk
Authors: Osterland Andrew J , Yasuda Marie , Widmer Robert J , Colavecchia Anthony C , Gums Tyler , Emir Birol , Nolen Kim , MacLean Elizabeth , Godley Paul J 
Published: September 2023

Abstract

Purpose
To measure the effect of clinical decision support (CDS) on anticoagulation rates in patients with atrial fibrillation (AFib) or atrial flutter (AFlut) at high stroke risk and receiving care in outpatient settings, and to assess provider response to CDS.

Methods
This observational, quasi-experimental, interrupted time series study utilized electronic health record data at a large integrated delivery network in Texas from April to November 2020. CDS consisted of an electronic Best Practice Advisory (BPA)/alert (Epic Systems Corporation, Verona, WI) with links to 2 AFib order sets displayed to providers in outpatient settings caring for non-anticoagulated patients with AFib and elevated CHA2DS2VASc scores. Weekly outpatient anticoagulation rates were assessed in patients with high stroke risk before and after implementation of CDS. Alert actions and acknowledgment reasons were evaluated descriptively.

Results
Mean (SD) weekly counts of eligible patients were 8,917 (566) before and 8,881 (811) after implementation. Weekly anticoagulation rates increased during the pre-BPA study period (β1 = 0.07%; SE, 0.02%; P = 0.0062); however, there were no significant changes in the level (β2 = 0.60%; SE, 0.42%; P = 0.1651) or trend (β3 = –0.01%; SE, 0.05%; P = 0.8256) of anticoagulation rates associated with CDS implementation. In encounters with the BPA/alert displayed (n = 17,654), acknowledgment reasons were provided in 4,473 (25.3%) of the encounters, with prescribers most commonly citing bleeding risk (n = 1,327, 7.5%) and fall risk (n = 855, 4.8%).

Conclusion
There was a significant trend of increasing anticoagulation rates during the pre-BPA period, with no significant change in trend during the post-BPA period relative to the pre-BPA period.
Seasonal variation in the xylem sap composition of six Australian trees and shrubs
Authors: Losso Adriano , Gauthey Alice , Choat Brendan , Mayr Stefan 
Published: September 2023

AbstractIn recent years, xylem sap composition has been shown to affect xylem hydraulics. However, information on how much xylem sap composition can vary across seasons and specifically under drought stress is still limited. We measured xylem sap chemical composition ([Ca2+], [K+], [Na+], electrical conductivity EC and pH) and surface tension (γ) of six Australian angiosperm trees and shrubs over 1 year, which comprised of exceptional dry and wet periods. Percentage losses of hydraulic conductivity and predawn leaf water potential were also monitored. In all species, measured parameters changed considerably over the annual time course. Ions and pH tended to decrease during winter months whereas γ showed a slight increase. No clear correlation was found between sap and hydraulic parameters, except for pH that was higher when plants suffered higher drought stress levels. Results indicate xylem sap composition to be complex and dynamic, where most variation in its composition seems to be dictated by season, even under severe dry conditions. However, pH might play a role as signals of drought stress.
XIII—Dear Octavia Butler
Authors: Dotson Kristie 
Published: September 2023

Abstract
One of Octavia Butler’s common sites of exploration concerns the impact of parenting on her main characters. She appeared to locate reproduction and child-rearing as parts of human life with great potentials for transformed futures. From a perspective of intergenerational survival, that hope appears perfectly reasonable. In this letter to Butler, I put the goal of intergenerational survival into question as an existential mandate by querying its relationship to gestative capture. Gestative capture here refers to the ready capacity to reduce an existent to immanence via their abilities to gestate ‘human’ or ‘human-like’ progeny. The conversation this letter stages with Butler and her work, which is only possible because of how clearly Butler understood gestative capture and how much she built it into her stories, asks the questions: What is ‘transcendence’ for Black women who can bear children? How ought we to imagine intergenerational survival? And when, if ever, should we put down ‘survival at all costs’ commitments?
Food supply and provisioning behavior of parents: Are small hoopoe nestlings condemned to die?
Authors: Ferrer-Pereira Paula , Martínez-Renau Ester , Martín-Vivaldi Manuel , José Soler Juan 
Published: September 2023

Abstract
Parents might use signals of need or of quality to decide food provisioning among their offspring, while the use of one or another signal might depend on food availability. Begging success of nestlings of different quality (i.e., body size) would also depend on food availability, and we here explore the effect of experimental food supply in begging success of nestlings and in provisioning of female hoopoes (Upupa epops), a species with extreme hatching asynchrony and nestlings size hierarchy. We video-recorded food allocation of females, begging success of nestlings of different size, and the social context (i.e., the size category of the other nestlings that were begging for food) during periods when experimental food supply was or was not available in the same nests. We found that when experimental food supplementation was present, begging success of the intermediate, but not that of large or small-sized nestlings, increased. The experiment, however, did not affect the feeding preferences of females toward nestlings of different size. Moreover, when small nestlings were the only ones that were begging for food, their begging success decreased in the experimental period, and females used supplemented prey to feed themselves. Those results, on one hand, confirm the importance of food availability for the begging success of nestlings of particular sizes and, on the other, indicate that females prefer to use extra food for their own rather than for the smallest nestlings. We discuss possible mechanisms explaining the detected experimental effects and the adaptive and nonadaptive explanations of mothers ignoring the small nestlings.
cloneRate: fast estimation of single-cell clonal dynamics using coalescent theory
Authors: Johnson Brian , Shuai Yubo , Schweinsberg Jason , Curtius Kit 
Published: September 2023

Abstract

Motivation
While evolutionary approaches to medicine show promise, measuring evolution itself is difficult due to experimental constraints and the dynamic nature of body systems. In cancer evolution, continuous observation of clonal architecture is impossible, and longitudinal samples from multiple timepoints are rare. Increasingly available DNA sequencing datasets at single-cell resolution enable the reconstruction of past evolution using mutational history, allowing for a better understanding of dynamics prior to detectable disease. There is an unmet need for an accurate, fast, and easy-to-use method to quantify clone growth dynamics from these datasets.

Results
We derived methods based on coalescent theory for estimating the net growth rate of clones using either reconstructed phylogenies or the number of shared mutations. We applied and validated our analytical methods for estimating the net growth rate of clones, eliminating the need for complex simulations used in previous methods. When applied to hematopoietic data, we show that our estimates may have broad applications to improve mechanistic understanding and prognostic ability. Compared to clones with a single or unknown driver mutation, clones with multiple drivers have significantly increased growth rates (median 0.94 versus 0.25 per year; P = 1.6×10−6). Further, stratifying patients with a myeloproliferative neoplasm (MPN) by the growth rate of their fittest clone shows that higher growth rates are associated with shorter time to MPN diagnosis (median 13.9 versus 26.4 months; P = 0.0026).

Availability and implementation
We developed a publicly available R package, cloneRate, to implement our methods (Package website: https://bdj34.github.io/cloneRate/). Source code: https://github.com/bdj34/cloneRate/.
VoDEx: a Python library for time annotation and management of volumetric functional imaging data
Authors: Nadtochiy Anna , Luu Peter , Fraser Scott E , Truong Thai V 
Published: September 2023

Abstract

Summary
In functional imaging studies, accurately synchronizing the time course of experimental manipulations and stimulus presentations with resulting imaging data is crucial for analysis. Current software tools lack such functionality, requiring manual processing of the experimental and imaging data, which is error-prone and potentially non-reproducible. We present VoDEx, an open-source Python library that streamlines the data management and analysis of functional imaging data. VoDEx synchronizes the experimental timeline and events (e.g. presented stimuli, recorded behavior) with imaging data. VoDEx provides tools for logging and storing the timeline annotation, and enables retrieval of imaging data based on specific time-based and manipulation-based experimental conditions.

Availability and implementation
VoDEx is an open-source Python library and can be installed via the “pip install” command. It is released under a BSD license, and its source code is publicly accessible on GitHub (https://github.com/LemonJust/vodex). A graphical interface is available as a napari-vodex plugin, which can be installed through the napari plugins menu or using “pip install.” The source code for the napari plugin is available on GitHub (https://github.com/LemonJust/napari-vodex). The software version at the time of submission is archived at Zenodo (version v1.0.18, https://zenodo.org/record/8061531).
Acoustic wave propagation in a porous medium saturated with a Kelvin–Voigt non-Newtonian fluid
Authors: Ba Jing , Fang Zhijian , Fu Li-Yun , Xu Wenhao , Zhang Lin 
Published: September 2023

SUMMARYWave propagation in anelastic rocks is a relevant scientific topic in basic research with applications in exploration geophysics. The classical Biot theory laid the foundation for wave propagation in porous media composed of a solid frame and a saturating fluid, whose constitutive relations are linear. However, reservoir rocks may have a high-viscosity fluid, which exhibits a non-Newtonian (nN) behaviour. We develop a poroelasticity theory, where the fluid stress-strain relation is described with a Kelvin–Voigt mechanical model, thus incorporating viscoelasticity. First, we obtain the differential equations from first principles by defining the strain and kinetic energies and the dissipation function. We perform a plane-wave analysis to obtain the wave velocity and attenuation. The validity of the theory is demonstrated with three examples, namely, considering a porous solid saturated with a nN pore fluid, a nN fluid containing solid inclusions and a pure nN fluid. The analysis shows that the fluid may cause a negative velocity dispersion of the fast P(S)-wave velocities, that is velocity decreases with frequency. In acoustics, velocity increases with frequency (anomalous dispersion in optics). Furthermore, the fluid viscoelasticity has not a relevant effect on the wave responses observed in conventional field and laboratory tests. A comparison with previous theories supports the validity of the theory, which is useful to analyse wave propagation in a porous medium saturated with a fluid of high viscosity.
A geraniol synthase regulates plant defense via alternative splicing in tea plants
Authors: Jiang Hao , Zhang Mengting , Yu Feng , Li Xuehui , Jin Jieyang , Zhou Youjia , Wang Qiang , Jing Tingting , Wan Xiaochun , Schwab Wilfried , Song Chuankui 
Published: September 2023

Abstract
Geraniol is an important contributor to the pleasant floral scent of tea products and one of the most abundant aroma compounds in tea plants; however, its biosynthesis and physiological function in response to stress in tea plants remain unclear. The proteins encoded by the full-length terpene synthase (CsTPS1) and its alternative splicing isoform (CsTPS1-AS) could catalyze the formation of geraniol when GPP was used as a substrate in vitro, whereas the expression of CsTPS1-AS was only significantly induced by Colletotrichum gloeosporioides and Neopestalotiopsis sp. infection. Silencing of CsTPS1 and CsTPS1-AS resulted in a significant decrease of geraniol content in tea plants. The geraniol content and disease resistance of tea plants were compared when CsTPS1 and CsTPS1-AS were silenced. Down-regulation of the expression of CsTPS1-AS reduced the accumulation of geraniol, and the silenced tea plants exhibited greater susceptibility to pathogen infection than control plants. However, there was no significant difference observed in the geraniol content and pathogen resistance between CsTPS1-silenced plants and control plants in the tea plants infected with two pathogens. Further analysis showed that silencing of CsTPS1-AS led to a decrease in the expression of the defense-related genes PR1 and PR2 and SA pathway-related genes in tea plants, which increased the susceptibility of tea plants to pathogens infections. Both in vitro and in vivo results indicated that CsTPS1 is involved in the regulation of geraniol formation and plant defense via alternative splicing in tea plants. The results of this study provide new insights into geraniol biosynthesis and highlight the role of monoterpene synthases in modulating plant disease resistance via alternative splicing.
Safety and Immunogenicity of a Revaccination With a Respiratory Syncytial Virus Prefusion F Vaccine in Older Adults: A Phase 2b Study
Authors: Leroux-Roels Isabel , Van Ranst Marc , Vandermeulen Corinne , Abeele Carline Vanden , De Schrevel Nathalie , Salaun Bruno , Verheust Céline , David Marie-Pierre , Kotb Shady , Hulstrøm Veronica 
Published: September 2023

Abstract

Background
In the previous (parent) study, 2 doses of different formulations of an investigational vaccine against respiratory syncytial virus (RSVPreF3 OA) were well tolerated and immunogenic in older adults. This multicenter phase 2b extension study assessed safety and immunogenicity of a revaccination (third) dose of the 120 μg RSVPreF3-AS01E formulation.

Methods
In total, 122 older adults (60–80 years), previously vaccinated with 2 doses of RSVPreF3-AS01E formulations (containing 30, 60, or 120 μg RSVPreF3 antigen), received an additional 120 μg RSVPreF3-AS01E dose 18 months after dose 2. Vaccine safety was evaluated in all participants up to 6 months and immunogenicity in participants who received 120 μg RSVPreF3-AS01E doses until 1 month after dose 3.

Results
Similar to the parent study, mostly mild-to-moderate solicited adverse events and no vaccine-related serious adverse events or potential immune-mediated disorders were reported. Neutralizing titers and cell-mediated immune responses persisted for 18 months after 2-dose vaccination. Dose 3 increased RSV-specific neutralizing titers against RSV-A and RSV-B and median CD4+ T-cell frequencies. After dose 3, RSV-specific neutralizing titers but not CD4+ T-cell frequencies were below levels detected 1 month after dose 1.

Conclusions
Revaccination with 120 μg RSVPreF3-AS01E 18 months after dose 2 is well tolerated and immunogenic in older adults.

Clinical Trials Registration
NCT04657198; EudraCT, 2020-000692-21.