bluuebunny/crossref_metadata_2025_split huggingface dataset:
So You Want Me to Believe You’re Happy or Angry? How Negotiators Perceive and Respond to Emotion Deception
Authors: Ye Zi , Lelieveld Gert-Jan , Noordewier Marret K. , van Dijk Eric 
Published: August 2023

AbstractPast work suggests that emotion deception in negotiations – communicating a different emotion than experienced – is perceived negatively. We, however, argue that this depends on the type of emotion deception. We compared two emotion deception types – communicating anger while actually being happy, and communicating happiness while being angry – to genuine communications of happiness and anger. In three preregistered experiments (N = 500), participants played the role of employee or supervisor and negotiated with an opponent about salary raises. After their initial offer, participants learned their opponent’s experienced (happiness vs. anger) and communicated emotion (happiness vs. anger). Then, participants made their final demand and reported perceptions of their opponent’s limits and sacrifice. Results showed that participants perceived opponents who communicated genuine anger as having stricter limits and conceded more to them than to opponents using the other emotion communication types. Moreover, opponents who communicated happiness but experienced anger were perceived as making more of a sacrifice than opponents who communicated anger but experienced happiness. In Experiment 3, we also examined effects of emotion deception on non-negotiated outcomes, by assessing the likelihood to hand the opponent a year-end bonus. Participants were most likely to allocate the bonus to opponents that truthfully communicated happiness. Moreover, participants were more likely to allocate the bonus to opponents who communicated happiness but experienced anger than to opponents who communicated anger but experienced happiness. These findings extend social functional accounts of emotion communication, by showing that effects of emotion deception depend on the type of experienced and/or communicated emotions.
Transgenerational expression profiles of a sex related and an epigenetic control gene in the rotifer Brachionus plicatilis in relation to environmental predictability
Authors: Colinas Noemi , Montero-Pau Javier , Carmona María José , Sabatino Raffaella , Di Cesare Andrea , Eckert Ester Maria , García-Roger Eduardo M. 
Published: August 2023

AbstractA non-genetic transgenerational inhibitory effect on sexual reproduction has been demonstrated in Brachionus plicatilis in relation to environmental predictability. Indeed, clones of this species from more predictable environments do not respond to sex-inducing cues during several generations after leaving diapause. Notwithstanding, the molecular basis of this effect is still unknown. In this work, the expression level of genes related to the synthesis of sex hormones and to a potential epigenetic signalling mechanism were tracked along successive generations from diapausing eggs in clones of B. plicatilis populations inhabiting ponds with different level of environmental predictability. The selected genes were (1) the 17-β-dehydrogenase gene (edh), involved in the synthesis of 17-β-estradiol hormone in rotifers, and (2) the DNMT2 gene (meth), as a candidate epigenetic mechanism of control. According to expectations, results showed an increasing expression of edh across generations in clones from those the more predictable ponds. This finding provides a putative role of estradiol in the transgenerational effect. However, no differences were found in the meth gene neither across generations nor regarding the environmental predictability. Despite this, we point out alternatives for future research on the inherited gene regulation mechanism behind the transgenerational effect.
“Madhyamakanising” Tantric Yogācāra: The Reuse of Ratnākaraśānti’s Explanation of maṇḍala Visualisation in the Works of Śūnyasamādhivajra, Abhayākaragupta and Tsong Kha Pa
Authors: Cheung Daisy S. Y. 
Published: August 2023

AbstractThe eleventh-century Indian Buddhist master Ratnākaraśānti presents a unique Yogācāra interpretation of tantric maṇḍala visualisation in the *Guhyasamājamaṇḍalavidhiṭīkā. In this text, he employs the neither-one-nor-many argument to assert that the qualities of the mind represented by the deities in the maṇḍala are neither the same nor different from the mind itself. He also provides five scenarios of meditation to explain the necessity of practising both the perfection method (pāramitānaya) and the mantra method (mantranaya) together in Mahāyāna. Ratnākaraśānti’s explanation exerts a significant influence on the works of later Buddhist masters in India and Tibet, with parts of it being reused in the *Śrīherukopadeśanāmasvādhiṣṭhānakrama by Śūnyasamādhivajra (c. the eleventh century), the eighteenth chapter of the Āmnāyamañjarī by Abhayākaragupta (from the late eleventh to the twelfth century) and the tantric compendium sNgags rim chen mo by the Tibetan master Tsong kha pa Blo bzang grags pa (1357–1419). This paper explores how Ratnākaraśānti’s explanation has been reused and modified in these subsequent works. While Śūnyasamādhivajra faithfully reproduced Ratnākaraśānti’s Yogācāra explanation, Abhayākaragupta modified it to align with his Madhyamaka view. Abhayākaragupta in turn influenced Tsong kha pa, who accepted Abhayākaragupta’s Madhyamaka modification in his works. This paper also engages with current scholarly discussions on textual reuse and the underlying reasons behind it. While Śūnyasamādhivajra and Abhayākaragupta assimilated Ratnākaraśānti’s explanation without acknowledgement, Tsong kha pa quoted the text by name and acknowledged Abhayākaragupta’s reuse of Ratnākaraśānti’s explanation. This paper concludes by discussing the factors that determine whether the reused text is acknowledged or not, and the possible reasons behind textual reuse.
Real life data on nintedanib safety: idiopathic pulmonary fibrosis versus systemic sclerosis-interstitial lung disease and strategies adopted to manage adverse effects
Authors: Di Battista Marco , Tavanti Laura , Pistelli Francesco , Carrozzi Laura , Da Rio Mattia , Rossi Alessandra , Puccetti Lorenzo , Tavoni Antonio , Romei Chiara , Morganti Riccardo , Della Rossa Alessandra , Mosca Marta 
Published: August 2023

Abstract
Objective
Nintedanib (NIN) is an antifibrotic drug approved to slow the progression of idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-related interstitial lung disease (SSc-ILD). NIN can frequently cause gastrointestinal adverse effects. We aimed to investigate the NIN safety profile in a real life setting, comparing IPF and SSc-ILD patients and evaluating the strategies adopted to manage NIN adverse effects.

Methods
Patients taking NIN for IPF or SSc-ILD were enrolled. Alongside epidemiological and disease-specific data, the period of NIN use and the need for dosage reduction and/or interruption were investigated. Particular attention was paid to possible adverse effects and strategies adopted to manage them.

Results
Twenty-seven SSc-ILD and 82 IPF patients were enrolled. No significant differences emerged between the two cohorts regarding the frequency of any possible adverse effect. Although the rates of NIN dosage reduction or interruption were similar between the two subgroups, SSc-ILD presented a mean period before NIN dosage reduction and NIN interruption significantly shorter than IPF (3 ± 2.6 vs 10.5 ± 8.9 months—p < 0.001 and 2.3 ± 0.5 vs 10.3 ± 9.9 months—p = 0.008, respectively). Several different strategies were tried to manage NIN adverse effects: especially in SSc-ILD, the variable combination of diet adjustment set by a nutritionist, probiotics and diosmectite was ultimately successful in maintaining patients on an adequate dose of NIN.

Conclusion
We presented data on the NIN safety profile in a real life setting, which was similar between SSc-ILD and IPF. A combination of multiple managing strategies and dose adjustment appears essential to cope optimally with NIN adverse effects.
On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023)
Authors: Cecil Charlotte A. M. , Schuurmans Isabel K. 
Published: August 2023

AbstractEarly life adversities (ELA), including exposure to childhood maltreatment, deprivation or community violence, rarely occur in isolation. This co-occurrence poses several conceptual and methodological challenges for researchers, who must decide how best to model ELA and its association with outcomes. In this commentary, we discuss how different analytical choices come with their own – often complementary – sets of assumptions, strengths and limitations, which should be carefully considered when designing research on ELA. We then summarize work published in this issue by Sisitsky et al. (Research on Child and Adolescent Psychopathology, 2023), which serves as an important example of how different approaches can be incorporated in research in order to capture ELA as a complex phenomenon, while generating actionable results. Ultimately, such integration can enhance the quality and relevance of research, contributing to a more comprehensive understanding of ELA and its effects on health outcomes, paving the way for more targeted prevention and intervention strategies to promote children’s wellbeing.
Complex peptide macrocycle optimization: combining NMR restraints with conformational analysis to guide structure-based and ligand-based design
Authors: Jain Ajay N. , Brueckner Alexander C. , Jorge Christine , Cleves Ann E. , Khandelwal Purnima , Cortes Janet Caceres , Mueller Luciano 
Published: August 2023

AbstractSystematic optimization of large macrocyclic peptide ligands is a serious challenge. Here, we describe an approach for lead-optimization using the PD-1/PD-L1 system as a retrospective example of moving from initial lead compound to clinical candidate. We show how conformational restraints can be derived by exploiting NMR data to identify low-energy solution ensembles of a lead compound. Such restraints can be used to focus conformational search for analogs in order to accurately predict bound ligand poses through molecular docking and thereby estimate ligand strain and protein-ligand intermolecular binding energy. We also describe an analogous ligand-based approach that employs molecular similarity optimization to predict bound poses. Both approaches are shown to be effective for prioritizing lead-compound analogs. Surprisingly, relatively small ligand modifications, which may have minimal effects on predicted bound pose or intermolecular interactions, often lead to large changes in estimated strain that have dominating effects on overall binding energy estimates. Effective macrocyclic conformational search is crucial, whether in the context of NMR-based restraints, X-ray ligand refinement, partial torsional restraint for docking/ligand-similarity calculations or agnostic search for nominal global minima. Lead optimization for peptidic macrocycles can be made more productive using a multi-disciplinary approach that combines biophysical data with practical and efficient computational methods.
A Cost-Effective Polychromator with a Single Interference Filter for Thomson Scattering Diagnostics
Authors: Kamiya Shun , Yamaguchi Haruka , Kim Jungkyun , Himeno Shun-ichi , Tanabe Hiroshi , Ono Yasushi 
Published: August 2023

AbstractWe propose a cost-effective polychromator with a single interference filter, because interference filters account for large parts of polychromator costs in the conventional Thomson scattering diagnostics with a Nd:YAG laser. Since the interference filters are used to transmit the scattered light in a specific wavelength range, one polychromator tends to have as many interference filters as its spectral channels, which makes high-resolution measurement with a number of polychromators expensive. However, we can save the number of interference filters and thus their costs by reentering reflected light from an interference filter into the same filter at different angles. This is possible, because the larger angle of incidence on the interference filter makes the wavelength of the transmitted light shorter. We measured dependence of transmitted wavelengths on the angles of incidence on one interference filter custom-ordered to transmit 1059 nm and developed the cost-effective polychromator using this dependence. The developed polychromator with a single filter successfully separated three different spectral channels (1043.2, 1051.9, and 1058.4 nm), enabling us to realize the cost-effective Thomson scattering diagnostics.
Plasma neurofilament light chain in relation to 10-year change in cognition and neuroimaging markers: a population-based study
Authors: van Arendonk Joyce , Wolters Frank J. , Neitzel Julia , Vinke Elisabeth J. , Vernooij Meike W. , Ghanbari Mohsen , Ikram M. Arfan 
Published: August 2023

AbstractNeurofilament light chain (NfL) is a promising biomarker for risk stratification and disease monitoring of dementia, but its utility in the preclinical disease stage remains uncertain. We determined the association of plasma NfL with (change in) neuroimaging markers and cognition in the population-based Rotterdam Study, using linear and logistic regression and mixed-effects models. Plasma NfL levels were measured using the Simoa NF-light™ assay in 4705 dementia-free participants (mean age 71.9 years, 57% women), who underwent cognitive assessment and brain MRI with repeated assessments over a 10-year follow-up period. Higher plasma NfL was associated with worse cognitive performance at baseline (g-factor: β =  − 0.12 (− 0.15; − 0.09), p < 0.001), and accelerated cognitive decline during follow-up on the Stroop color naming task (β = 0.04 (0.02; 0.06), p < 0.001), with a smaller trend for decline in global cognition (g-factor β =  − 0.02 (− 0.04; 0.00), p = 0.044). In the subset of 975 participants with brain MRI, higher NfL was associated with poorer baseline white matter integrity (e.g., global mean diffusivity: β = 0.12 (0.06; 0.19), p < 0.001), with similar trends for volume of white matter hyperintensities (β = 0.09 (0.02; 0.16), p = 0.011) and presence of lacunes (OR = 1.55 (1.13; 2.14), p = 0.007). Plasma NfL was not associated with volumes or thickness of the total gray matter, hippocampus, or Alzheimer signature regions. In conclusion, higher plasma NfL levels are associated with cognitive decline and larger burden of primarily white matter pathology in the general population.
Investment in two alternative projects with multiple switches and the exit option
Authors: Kravchenko Igor V. , Nunes Cláudia , Oliveira Carlos 
Published: August 2023

AbstractThis paper uses an analytical framework to examine a firm’s investment and switching strategy under uncertainty. The context is the possibility to launch and operate two distinct projects, one at a time, with exposure to a stochastic exogenous price. We allow for multiple switches between the two projects, along with abandonment options from each. These possibilities fundamentally influence the operational strategy. We show that under some conditions, a dichotomous waiting region may arise at the investment stage. In this case we have an inaction region, for a range of prices in a certain bounded interval, where the firm does not invest and waits to have more information about the price evolution. This region vanishes for a high level of uncertainty. Additionally, the firm may operate with a negative instantaneous profit. We prove that investment in this region is never optimal. Numerical examples enable comparative statics, while extension to allow for time-to-build is included.
American Philanthropy in the Age of Political Polarization: Conservative Megadonors and Foundations and Their Role in Spreading Climate Skepticism
Authors: Rauscher Natalie 
Published: August 2023

AbstractWealthy citizens have influenced public debates and the political process in the United States in many ways, for example through donations or campaign finance. Philanthropy is viewed increasingly as another vehicle of more indirect elite influence. Although institutionally designed to stay above the partisan fray, philanthropy has increasingly been politicized over the last decades against the backdrop of growing partisan polarization. The conservative side in particular has consolidated influence through conservative foundations, think tanks, and new tools of giving such as donor-advised funds. Climate change is one issue in which conservatives have pushed skeptical views and disinformation over the last decades. Conservative actors backed by philanthropic activity have shaped public discourse according to climate-skeptic views and have worked to block political action on climate change while also forming global networks and practices across the Atlantic. While trying to retain the image of academic research and political neutrality, right-wing European think tanks are spreading climate change disinformation, often with connections to their American counterparts and with the support of American conservative donors and foundations. Overall, this paper argues that parts of the philanthropic sector in the United States have abandoned early notions of public charity in order to pursue considerable societal and political goals under the guise of philanthropic activity that provides tax benefits and the image of political neutrality. This paper builds on research that shows how much the interests of the wealthy are reflected in political decision-making in the United States (Bartels 2008; Page, Bartels, and Seawright 2013; Gilens and Page 2014), dark money debates in U.S. politics (Mayer 2017; Oklobdzija 2019), and discussions around the role of philanthropic foundations in a democratic society (Reich 2013, 2018).
Dimensional Effects of Hybrid Bond Layers on CFRP Metallized by Ti Cold Spray
Authors: Feng Po-Lun , Kim Kinal , Blassino Adolfo , Nault Isaac , Lee Sang-Eui , Nutt Steven 
Published: August 2023

AbstractHybrid bond layers (BLs) were designed, fabricated, and evaluated for cold spray metallization of CFRP. The bond layers consisted of metal mesh embedded in a polymer film adhesive co-cured to the CFRP. Efforts were devoted to identifying the critical opening ratio—i.e., the ratio of mesh opening size to powder diameter, for deposition of an adherent coating. Analysis of powder deposited at mesh openings show a transition from erosion (at a mesh opening ratio of 6.4) to mechanical interlocking and formation of a continuous coating with decreasing opening ratio. Selection of opening ratio yielded either (a) a grid of consolidated thin-walled deposits atop mesh wires separated by microchannel openings, or (b) densified coatings of cold-sprayed Ti. The effective opening ratio increased with increasing diameter ratio—i.e., the ratio of wire diameter to powder size, a consequence of eroded wire peripheries at shallow impact angles. These findings inform the design of future hybrid BLs, in concert with the selection of powder size, for cold spray metallization of CFRP.
Oxidation and wear behavior of CrAlMoN with varied Mo-content for cutting Ti6Al4V
Authors: Bobzin K. , Kalscheuer C. , Stachowski N. , Dege J. , Hintze W. , Möller C. , Ploog P. 
Published: August 2023

AbstractThe cutting of difficult to machine materials such as titanium alloys is challenging for the machining industry. In case of the titanium alloy Ti6Al4V, the properties of the material cause high temperatures, mechanical loads as well as high frequency vibrations at the cutting edge, leading to premature tool failure. The use of uncoated carbide tools is very common for machining of Ti based alloys. However, temperature active, self-lubricating physical vapor deposition (PVD) coatings like CrAlMoN showed promising results to reduce friction and wear during turning of Ti6Al4V. In the present study, self-lubricating (Cr34Al41Mo25)N, (Cr29Al36Mo35)N and (Cr25Al31Mo44)N coatings were investigated on cemented carbide tools. These were deposited by a hybrid process combining direct current Magnetron Sputtering and High Power Pulsed Magnetron Sputtering. Coating morphology, thickness, chemical composition, indentation hardness and modulus at ϑ = 20 °C, ϑ = 200 °C, ϑ = 400 °C and ϑ = 600 °C as well as the oxidation behavior were analyzed. Moreover, wear development after cutting tests using a CNC-lathe was investigated. Independent of Mo-content, all coating variants possessed a dense morphology and a smooth surface topography, as well as a coating adhesion class of HF1 to the cemented carbide substrate in Rockwell indentation tests according to DIN 4856. With an increasing amount of Mo, heat treatment temperature and time, more self-lubricating molybdenum oxides such as MoO3 and Mo4O11 were detected by Raman spectroscopy. Therefore, the coating with the highest amount of Mo possessed the highest amount of molybdenum oxides. After cutting tests, molybdenum oxides were also found on the tool flank face by Raman spectroscopy. The level of flank wear land width decreased with increasing amount of Mo.
Sex assessment from the pelvis: a test of the Phenice (1969) and Klales et al. (2012) methods
Authors: Jager Vanessa Rae , Eliopoulos Constantine 
Published: August 2023

AbstractSex assessment is one of the first steps of routine forensic anthropological examinations and it provides a crucial element to identify a set of human skeletal remains. In bioarchaeological contexts, this assessment is also important, as it helps in the reconstruction of past societies. Sex determination can be achieved by using several morphological or metric traits of the skull and postcranial skeleton, which have been found to have varying degrees of accuracy. In 1969 Phenice proposed a methodology focusing on three traits located on the pubis. These traits were described as either having a female or male morphology with ambiguity being rare. Phenice’s method became regularly utilized as it was considered to be reliable. In 2012, Klales and colleagues published a revision of Phenice’s method, as they found that it did not capture the variation in the expression of the three traits. Klales and co-authors created a visual ordinal scale of 1–5 for each of the three traits Phenice originally identified, thus adding three extra possible forms of expression. The purpose of the present research was to test both the original and revised methodologies on the same skeletal population in order to evaluate their suitability for the assessment of sex. The Luís Lopes Anthropological collection in Lisbon was used; 117 males and 117 females were scored using both methodologies. The results showed that the original method performed better (96.5% accuracy) than the revised method (92.7%).