bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of chemo- and bio-catalysis to intensify bioprocesses
Authors: Liu Yunting , Gao Shiqi , Liu Pengbo , Kong Weixi , Liu Jianqiao , Jiang Yanjun 
Published: March 2023

Abstract
Nature has evolved highly efficient and complex systems to perform cascade reactions by the elegant combination of desired enzymes, offering a strategy for achieving efficient bioprocess intensification. Chemoenzymatic cascade reactions (CECRs) merge the complementary strengths of chemo-catalysis and bio-catalysis, such as the wide reactivity of chemo-catalysts and the exquisite selective properties of biocatalysts, representing an important step toward emulating nature to construct artificial systems for achieving bioprocess intensification. However, the incompatibilities between the two catalytic disciplines make CECRs highly challenging. In recent years, great advances have been made to develop strategies for constructing CECRs. In this regard, this chapter introduces the general concepts and representative strategies, including temporal compartmentalization, spatial compartmentalization and chemo-bio nanoreactors. Particularly, we focus on what platform methods and technologies can be used, and how to implement these strategies. The future challenges and strategies in this burgeoning research area are also discussed.
First report of type 2 diabetes mellitus in an adult with 3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency
Authors: Lai Valerie , Shahidi Mariam , Chan Alicia , Jain-Ghai Shailly 
Published: March 2023

Summary
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lyase deficiency is an inborn error of metabolism resulting in a lack of ketogenesis and leucine catabolism. Hallmarks of decompensation include hypoglycemia without ketosis (or hypoketosis), metabolic acidosis, and hyperammonemia. Management includes avoiding fasting and restricting dietary protein and fat. Conversely, type 2 diabetes mellitus (T2DM) requires carbohydrate restriction and/or anti-hyperglycemic agents; thus, managing these co-existing disorders is challenging. A 36-year-old male with HMG-CoA lyase deficiency and T2DM (Hemoglobin A1c (HbA1c): 7.9%) presented with confusion and shock. Blood work revealed metabolic acidosis, hyperammonemia, hyperglycemia, and hypoketosis. The patient was diagnosed with hyperosmolar non-ketotic hyperglycemia and hyperammonemia secondary to HMG-CoA lyase metabolic decompensation requiring intensive care unit admission. Hyperammonemia management was challenging because alternative calories with i.v. dextrose (due to hyperglycemia) and i.v. lipids (due to HMG-CoA lyase deficiency) could not be provided as usual. The patient was started on hemodialysis and i.v. insulin with marked improvement. Once stabilized, metformin and insulin were initiated. T2DM impaired cellular glucose uptake and produced a state similar to hypoglycemia, despite the patient being profoundly hyperglycemic, which led to metabolic decompensation of HMG-CoA lyase deficiency. Managing T2DM and HMG-CoA lyase deficiency warrants special considerations due to the potential for metabolic decompensation with both hyperglycemia and hypoglycemia.

Learning points

In a patient with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lyase deficiency and type 2 diabetes mellitus (T2DM), management principles include avoiding hypoglycemia to prevent metabolic decompensation, providing insulin for proper glucose utilization, and moderation of carbohydrate intake to prevent consequences of chronic hyperglycemia.

The development of insulin resistance in the form of T2DM in HMG-CoA lyase deficiency likely triggered a state similar to hypoglycemia, leading to cellular energy deficiency and subsequently metabolic decompensation.

It is important to avoid hypoglycemia in patients with HMG-CoA lyase deficiency and T2DM, as the risk of metabolic decompensation is increased due to the lack of ketogenesis in HMG-CoA lyase deficiency.

Selection of antidiabetic agents in this patient population requires careful consideration, and agents that have a higher risk of hypoglycemia should be avoided.
Surgical Treatment of Stenosing Tenosynovitis: Early and Late Outcomes, Complications
Authors: Varkalys Karolis , Knystautas Saulius , Braziulis Kęstutis , Tamaliūnas Vytautas , Zacharevskij Ernest 
Published: March 2023

Background. The thickening of A1 pulley of the tendon sheath limits the excursion of flexor tendon. Stenosing tenosynovitis causes finger movements dysfunction and pain. Objective. To analyze early and late outcomes of patients with stenosing tenosynovitis after surgical treatment – anulotomy. Methods. All patients had standard surgical procedure – open anulotomy of A1 pulley. Pain (verbal pain scale), hand and arm function (QuickDASH) and complications were recorded before surgery, after 1 week, 3 months and 6 months post surgery. Results. There were 45 patients, 29 (64%) female, 16 (36%) male. The highest pain score was recorded before surgery median 5 (IQR 5). The lowest pain score median 2 (IQR 2) was recorded after 6 months post surgery. The difference of the results after 1 week, 3 months and 6 months was statistically significant p < 0.001. The worst hand and arm function was before surgery and 1 week post surgery. Accordingly: medians 52 (IQR 33) and 52 (IQR 35). Full hand function recovery was noticed after 6 months post surgery median 0 (IQR 11). The difference is statistically significant p < 0.001. Conclusions. Surgical treatment, open anulotomy is one of the most effective methods for stenosing tenosynovitis. After this procedure pain and hand function improves greatly. However, for some patients it might cause discomfort of the hand because of the scar’s sensitivity and location.
El trabajo como un factor de riesgo en la Enfermedad Pulmonar Obstructiva Crónica (EPOC) y otras patologías respiratorias. Revisión narrativa de literatura
Authors: Mejía Argüello Jairo Emilio , González Ángel Lilian Alejandra 
Published: March 2023

Introducción: Las actividades laborales, especialmente aquellas relacionadas con la manufactura y procesamiento de múltiples materiales necesarios para la producción de bienes, conllevan riesgos para la salud de los trabajadores. La Enfermedad Pulmonar Obstructiva Crónica-EPOC es una condición respiratoria que afecta a diversos grupos laborales. La evidencia investigativa reciente indica que dentro de los factores de riesgo asociados al desarrollo de la EPOC es necesario considerar el tipo de trabajo, trascendiendo la clásica atribución causal al hábito de fumar. La frecuencia como una de las tres primeras causas de morbilidad y los impactos por carga de enfermedad en lo social, económico y laboral ameritan un conocimiento actualizado de la relación existente entre el trabajo y la EPOC.
Métodos: Se realizó una revisión narrativa con 59 estudios publicados en español e inglés en PubMed, Science Direct, Scopus, SCIELO y Web of Sciences, entre los años de 2004 a 2022 empleando como criterios de búsqueda enfermedad respiratoria laboral, trabajo y EPOC, factores de riesgo laborales.
Conclusión: Diversas actividades laborales poseen asociación causal con la EPOC, por lo cual se requiere mejorar los criterios diagnósticos tempranos en las personas con síntomas respiratorios, indagando por el tipo de trabajo, sus características, manipulación de sustancias y tiempo de exposición a ellas, ya que existe subregistro de su incidencia y precariedad diagnóstica, aun disponiendo de procedimientos diagnósticos y terapéuticos pertinentes al manejo adecuado de la patología.
Estrés y representación del confinamiento por la COVID-19, en ciclistas profesionales del Valle del Cauca
Authors: Lasso López Edward Andrés , Vivas-Manrique Samuel David , Ordoñez Hernandez Cecilia Andrea 
Published: March 2023

Objetivo: Identificar el nivel de estrés y las representaciones sociales asociadas al confinamiento generado por la emergencia sanitaria por Covid-19 en trabajadores ciclistas profesionales del Valle del Cauca en el año 2020.
Métodos: Se aplicó cuestionario en línea con la técnica de listado libre de palabras y la tercera versión del cuestionario para la evaluación del estrés del Ministerio de Trabajo de Colombia y la Pontificia Universidad Javeriana a 57 personas que trabajan como ciclistas profesionales. Los datos del listado libre se analizaron en el paquete estadístico Antrophac, bajo análisis prototípico y consensual de los datos y los datos de estrés con el paquete estadístico SPSS versión XXIII.
Resultados: se encontró que el 52.8% de los ciclistas presentan estrés con sintomatología predominantemente fisiológica como dolor muscular en cuello y espalda, dolor de cabeza y trastornos del sueño. Las representaciones asociadas al confinamiento se agruparon en 5 ejes principales: factores protectores, afectaciones emocionales y comportamentales, estresores, estrategias de afrontamiento, y cuidado de la salud de sí mismo y de otros.
Conclusiones: Las palabras encierro, protección y restricción aparece en todos los deportistas. Aquellos que presentaron estrés o tendencia, también asociaron el confinamiento a aburrimiento y estrés; mientras que aquellos que no presentan estrés asociaron las palabas familia y aprendizaje.
Síndrome de visión por computadora. Una revisión de un problema ocular poco advertido.
Authors: Pachon Robles Cindy Alejandra , Maturín Cordoba David Antonio , Mena Rentería Alba Adriana , Copete Quinto Adriana Lucía , Castro Álvarez John Fredy 
Published: March 2023

Introducción: Diversas manifestaciones principalmente visuales y musculoesqueléticas se han asociado a la exposición frecuente a pantallas de diferentes dispositivos electrónicos. Dichas afectaciones configuran el síndrome de visión por computadora (SVC), el cual impacta a alrededor de 60 millones de personas a nivel mundial y afecta significativamente el desempeño de sus labores cotidianas.
Objetivo: Revisar la literatura científica de los factores asociados al desarrollo del síndrome de visión por computadora y las medidas encaminadas a su manejo o prevención.
Materiales y Métodos: Revisión temática, donde se recopiló literatura científica en Pubmed, LILACS y SciELO, en idiomas inglés y español de los últimos 20 años, haciendo uso de querys de búsqueda con términos DeCS y MeSH.
Resultados: Se seleccionaron 50 estudios de 125 indexados, los cuales cumplían con los criterios de inclusión, de los que se obtuvo información valiosa sobre síntomas, factores asociados, datos epidemiológicos tanto globales como locales, conocimiento actual, medidas preventivas y tratamiento.
Conclusión: Alto número de estudios dan cuenta de la elevada prevalencia de síntomas asociados al SVC entre los usuarios de dispositivos electrónicos. A su vez, se evidencia un gran déficit en conocimiento sobre el SVC, tanto en estudiantes como personal administrativo, lo cual podría llevar al desarrollo silencioso de la enfermedad. En Colombia, aún es insuficiente la investigación sobre este tópico. Con respecto, a las intervenciones preventivas se consideran esenciales para el mejoramiento de la sintomatología y así evitar que esta entidad se convierta en una problemática de salud pública.
El desarrollo de competencias matemáticas y el uso de instrumentos de evaluación
Authors: Núñez Cárdenas Jhoscelyn , Damián Núñez Edgar Froilán 
Published: March 2023

En el presente artículo es el insumo del trabajo que tiene como propósito establecer el nivel de desarrollo de las competencias matemáticas por medio del uso de instrumentos de evaluación en estudiantes de sexto grado de educación primaria de una IE privada en el distrito de San Miguel de la ciudad de Lima en el año 2022, para lo cual se ha sometido a sesenta estudiantes a los cuales se les evaluó en pretest y postest; de los cuales treinta estudiantes se les ha sometido a una intervención donde las principales herramientas fueron los instrumentos de evaluación; el pretest y postest fueron una lista de cotejo en la que se recogió la evidencia del desarrollo de competencias cuando los estudiantes desarrollan diferentes problemas de contexto intra y extra matemático; la investigación fue de tipo experimental, longitudinal con un diseño cuasiexperimental con un enfoque cuantitativo; luego del tratamiento estadístico; donde se estableció que las características del grupo control y del grupo experimental, que son similares al iniciar luego del experimento, muestran diferencias relevantes; así también, el grupo experimental muestra un desarrollo significativo antes y después del experimento; dicho desarrollo es significativo mostrando la eficiencia y efectividad del experimento.
Air Two-Phase Flow Void Fraction – Water and Oil Emulsion on Mini Pipe with a slope of 600 Against Horizontal Position
Authors: Sukamta Sukamta 
Published: March 2023

The utilization of two-phase or multi-component flow in mini pipes is often found in the industrial world, such as mini evaporators, mini heat exchangers, etc. Multi-component flow can also be found in the biomedical, such as in the human circulatory system through vessels. An important parameter in a two-phase flow is the hollow fraction since this parameter significantly affects the flow pattern, which affects pressure fluctuations. Therefore, this study aims to obtain primary experimental data on the vacuum fraction, specifically in the air flow-water and oil emulsions with concentrations of 350 mg/dl and 500 mg/dl at an inclination of 60o to the horizontal. The study used a glass pipe with a diameter of 1.6 mm and a length of 160 mm. Data were captured using a high-speed camera at a gas superficial velocity (JG) = 0.083 m/s - 74.604 m/s and the superficial velocity of the liquid (JL) = 0.041 m/s - 4.145 m/s, and processed using MATLAB R2014a software. The results showed that the difference in the concentration of water and oil emulsions significantly affects the void fraction value, thus affecting the flow pattern. This case is because the difference in the concentration of water and oil emulsions affects the viscosity value, ultimately affecting the liquid's superficial velocity. Similarly, the slope of the pipe 60o to the horizontal affects the flow pattern that occurs; this is because the slope of the pipe will cause the influence of gravitational acceleration on the value of the superficial velocity of gases and liquids, although not very significant. The rise and fall of the gas's superficial velocity and the liquid's superficial velocity affect the value of the hollow fraction. More plug, slug-annular, annular, and churn flow patterns were identified than bubbly flow patterns, which is why the hollow fraction increased with the gas's superficial velocity and decreased with low superficial velocity. This kind of flow pattern needs to be watched out for because it has the potential to increase pressure significantly.
A prospective study of maternal outcome of labor and perinatal outcome in premature rupture of membranes
Authors: Andrabi Syed Uzma , Khan Ishtiyaq Ahmad , Bashir Nadia , Nisa Zeenat U. 
Published: March 2023

Background: Premature rupture of membranes refers to rupture of fetal membranes prior to the onset of labor. PROM is of two types viz. term PROM and preterm PROM. The incidence of PROM is at an average of 10%. In 70% of the cases, it occurs in pregnancies at term. Preterm PROM- defined as PROM prior to 37 weeks of gestation- complicates 2% to 4% of all singleton and 7% to 20% of twin pregnancies. It is the leading identifiable cause of premature birth and accounts for approximately 18% to 20% of perinatal deaths.
Methods: This study was conducted in the tertiary care teaching institute in the state of Jammu and Kashmir, India. After taking an informed consent, a proforma was filled on subject history, examination and investigations. These subjects were followed until delivery and then neonates were also followed.
Results: Incidence of PROM was 8.76% of which 54.7% were primigravida and 45.3% were multigravida. Most of the patients (70.4%) were term, only 29.6% were preterm with gestational age of <37 weeks. Incidence of PPH was 2.8%, puerperal pyrexia occurred in 9.8%. The incidence of RDS in neonates was 8.9% while the incidence of neonatal sepsis was 6.7%. There was 1.1% perinatal mortality.
Conclusions: From this study it can be concluded that basic aim of obstetrician should be to identify the risk factors leading to PROM, to treat complications and implement strict aseptic precautions to prevent maternal and neonatal morbidity.
A rare case scenario of didelphic uterus with ovarian serous cystadenocarcinoma: an unusual clinical finding
Authors: Sharma Medhavi , Sharma Gaurav , Varshney Shivangi 
Published: March 2023

Uterine didelphys in women is uncommon. The improper development of the Mullerian ducts during the intrauterine period leads to congenital abnormalities of the female genital system. Mullerian duct canalization or improper fusion leads to a didelphic uterus. About 60% of ovarian neoplasms are epithelial in origin, and the surface epithelium is typically most affected. This case report describes the management of a patient who had previously undergone two caesarean sections for a rare gynecological case of didelphic uterus with unilateral serous cystadenocarcinoma of the ovary.
Evaluation of reliability & reproducibility of cephalometric measurements obtained from computerised software (CS8100SC) compared with manual tracing
Authors: Pragya Prakhar , Sood Sankalp , Mahajan Monika , Chainta Dimple , Negi KS 
Published: March 2023

This study has been done to compare fourteen cephalometric measurements collected from computerized tracing of digital radiographs followed by manual tracing of the same to check their reliability and reproducibility.Pretreatment lateral cephalograms of fifty subjects were taken, on which fourteen cephalometric measurements were traced. Ten randomly selected cephalograms were retraced by the same operator both manually and digitally.Out of fourteen parameters, eight parameters (N-ANS, S-N, A-Pog, Facial angle, FMA, SNA, SNB and ANB) showed statistically significant differences between the two techniques but were clinically acceptable whereas six parameters did not show any significant differences. Digital measurements obtained from CS8100SC software were reliable for all except ANB. Reproducibility between both the tracing was good except for ANB, Facial axis, Facial angle and FMIA.CS8100SC Imaging software program can be brought into play for cephalometric measurements.
Congenital umbilical epidermal inclusion cyst masquerading as raspberry tumor– A common cyst in rare site
Authors: Raj Swati 
Published: March 2023

Umbilical tumours or lesions are rare; therefore, it is of outmost importance to navigate every umbilical nodule or growth cautiously. Only 10 cases have been reported to date. The present case has been diagnosed as congenital EIC in the umbilicus, the first time this has been reported in the archives.A 5 year old female child with umbilical nodular swelling since birth presented to the surgery OPD.A clinical diagnosis of "umbilical adenoma" was made. An excisional biopsy with abdominoplasty was done under general anaesthesia, and the specimen was submitted for HPE. On gross examination, we received an umbilical stump measuring 1 x 1 x 0.4 cm. A raised, firm nodular swelling was noted on the umbilical knot along with keratin debris. On cut, it showed a well-circumscribed, tiny gray-white nodule measuring 0.5 x 0.4 cm. On microscopic examination, a diagnosis of “Umbilical Epidermal Inclusion Cyst”was given.: Umbilical EIC is a rare entity that may present as an umbilical nodule and is detected in every age group with a female preponderance. Underlying etiopathogenesis can be congenital, idiopathic, or post-iatrogenic. Over 80% of the umbilical EIC is located above the fascia. The histopathological examination is the only modality that leads to an exact diagnosis and is considered the “gold standard” for detection of commonest cyst occurring in the rare site.
A religião dos celulares: consumo de tecnologia como expressão de fé entre evangélicos e umbandistas
Authors: Silva Sandra Rubia da 
Published: March 2023

Ao longo de onze meses de trabalho de campo em um bairro de camadas populares em Florianópolis, pude constatar importantes conexões entre o consumo de telefones celulares e a vivência da religiosidade entre evangélicos e umbandistas. Neste artigo, exploro as maneiras pelas quais os telefones celulares estão presentes no discurso e nas práticas religiosas desses dois grupos, percebendo o celular tanto como mediador positivo quanto negativo. A partir da análise do material etnográfico, argumento que a associação entre religião e uso de telefones celulares, além de aliviar a experiência da pobreza, traz renovadas possibilidades de expressão da identidade religiosa. Sugiro também que a dimensão política está presente, na medida em que suas funcionalidades – em especial o bluetooth e o SMS - auxiliam na disseminação do discurso religioso e na obtenção de novos adeptos.
Informação e responsabilização eleitoral: o caso do Movimento Voto Consciente
Authors: Praça Sérgio 
Published: March 2023

A população brasileira costuma ser menos informada em relação aos candidatos a cargos proporcionais que aos majoritários. Em São Paulo, uma organização da sociedade civil tem por objetivo esclarecer os eleitores a respeito daqueles parlamentares que a entidade julga merecerem a reeleição. Para isso, uma lista em anos eleitorais é divulgada com a ajuda da mídia. Este trabalho busca dimensionar a importância desta entidade para a accountability vertical do sistema político, ou seja, em que medida os eleitores recompensam os parlamentares apontados como os melhores.
Palavras-chaves: Eleições legislativas, responsabilização eleitoral, terceiro setor.
ABSTRACT
It is notorious that brazilian voters know more about candidates for the Executive than for the Parliaments. When legislative elections occur, an NGO based in São Paulo draws up a list of what they think are the best candidates for reelection in the City Council. Our text intends to conclude exactly how important the Movimento Voto Conscientes list is to the promotion of electoral accountability in a system that discourages this type of popular control.
Keywords: City council elections, electoral accountability,
NGOs.
Publicidade: o fazer-valer
Authors: Golobovante Maria da Conceição 
Published: March 2023

Em busca de uma epistemologia da comunicação publicitária, e em especial da sua ocorrência no espaço urbano, este artigo questiona a visão da publicidade como uma atividade comercial per se, ao problematizar sua construção como discurso valorizante de bens e serviços, ou seja, a validade desta prática está condicionada à sua capacidade de produzir linguagem e, portanto, cultura.
Palavras-chave: Publicidade; marketing; mídia; cidade.
ABSTRACT
This article is looking for an advertisings epistemology, especially on the outdoor ads presents in the urban space, challenging right the idea of advertising as only a commercial activity. Its valorizing speech connected to the goods and services ratifyes its real value as a cultural production.
Keywords: Advertising; marketing; media; city.