bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inventory Sharing for Perishable Products: Application to Platelet Inventory Management in Hospital Blood Banks
Authors: Zhang Can , Ayer Turgay , White Chelsea C. , Bodeker Joy N. , Roback John D. 
Published: December 2022

A Simple and Provably Good Inventory Policy Led to a Significant Reduction in Platelet Outdates Platelets are critical blood products. The management of platelet inventory is particularly challenging because of its perishable nature with a short shelf life. This paper studies how the wastage of platelets and, more broadly, perishable products can be reduced through inventory sharing. The authors derive structural results on the optimal ordering and transshipment policies for a two-location perishable inventory system and prove that an easy-to-implement myopic transshipment policy is optimal for a few special cases relevant to practice and serves as a lower bound on the optimal transshipment policy for more general settings. This policy has been successfully implemented by the Emory University Hospital System, which led to a reduction of approximately 20% in platelet outdates. Moreover, this paper also sheds light on how the presence of inventory sharing affects the optimal ordering quantities and provides insights that significant depart from existing findings for nonperishable inventory systems.
Super-channel spectrum saving optimization procedure in elastic optical networks
Authors: Radovic Margita , Sgambelluri Andrea , Cugini Filippo , Sambo Nicola 
Published: December 2022

Optical networks have historically been overprovisioned for physical-layer conditions and capacity and, as such, operate uninterrupted over several years. By reducing system margins, network efficiency and cost savings could be improved without compromising network reliability. On the other hand, super-channel transmission has been identified as a suitable solution for supporting high-data-rate connectivity. NETCONF, along with YANG models, has been recognized as a software defined networking (SDN) configuration and management protocol enabling control in a vendor-neutral way. Moreover, the OpenConfig YANG model defines vendor-specific transmission parameters, such as modulation format and bit rate, within operational modes. This paper investigates the trade-off between super-channel quality of transmission (QoT) and spectrum saving by allowing slight subcarrier overlap and tight filtering, hence reducing system margins. An automatic spectrum-efficient super-channel optimization procedure is experimentally demonstrated using a 600 Gbit/s transponder in an SDN-controlled elastic optical network. The automatic procedure performs the adaptation of filter bandwidth and subcarrier spacing. The latter is effectively operated by transponder agents, without involving the SDN controller, thus reducing the margins while guaranteeing that the QoT enables savings of up to 25% of the spectrum.
In Between Communication Theories through One Hundred Questions, Tomas Kačerauskas and Algis Mickūnas (2020)
Authors: Carpentier Nico 
Published: December 2022

Review of: In Between Communication Theories through One Hundred Questions, Tomas Kačerauskas and Algis Mickūnas (2020)
Cham: Springer, 278 pp.,
ISBN 978-3-03041-105-3, h/bk, EUR 98.09
ISBN 978-3-03041-108-4, p/bk, EUR 98.09
ISBN 978-3-03041-106-0, e-book, EUR 74.89
On the taxonomy and diversity of Cruciferae in Kazakhstan
Authors: German Dmitry A. , Vesselova Polina V. 
Published: December 2022

Taxonomy and species diversity of the mustard family (Cruciferae or Brassicaceae) in Kazakhstan is updated. Draba bajtenovii described and hitherto known from Kungei Alatau is synonymized with D. fladnizensis for which it is a southern limit of distribution in the Eurasia, while Trans-Ili Alatau endemic D. microcarpella is found conspecific with a montane Asian D. lanceolata. Noccaea thlaspidioides (N. cochleariformis) is confirmed to occur in the country based on collections from Altai. Finally, Isatis trachycarpa and Smelowskia annua are shown to be absent in the flora of Kazakhstan due to the lack of gatherings confirming their occurrence in the country.
Comparative Performance of Endoscopic Ultrasound-Based Techniques in Patients With Pancreatic Cystic Lesions: A Network Meta-Analysis
Authors: Li Shi-yu , Wang Zhi-jie , Pan Cheng-ye , Wu Cheng , Li Zhao-shen , Jin Zhen-dong , Wang Kai-xuan 
Published: December 2022

INTRODUCTION:
Evidence on the comparative diagnostic performance of endoscopic ultrasound (EUS)-based techniques for pancreatic cystic lesions (PCLs) is limited. This network meta-analysis comprehensively compared EUS-based techniques for PCL diagnosis.

METHODS:
A comprehensive literature search was performed for all comparative studies assessing the accuracy of 2 or more modalities for PCL diagnosis. The primary outcome was the diagnostic efficacy for mucinous PCLs. Secondary outcomes were the diagnostic efficacy for malignant PCLs, diagnostic success rate, and adverse event rate. A network meta-analysis was conducted using the ANOVA model to assess the diagnostic accuracy of each index.

RESULTS:
Forty studies comprising 3,641 patients were identified. The network ranking of the superiority index for EUS-guided needle-based confocal laser endomicroscopy (EUS-nCLE) and EUS-guided through-the-needle biopsy (EUS-TTNB) were significantly higher than other techniques for differentiating mucinous PCLs; besides, EUS-TTNB was also the optimal technique in identifying malignant PCLs. The evidence was inadequate for EUS-nCLE diagnosing malignant PCLs and contrast-enhanced harmonic EUS diagnosing both mucinous and malignant PCLs. Glucose showed a high sensitivity but low specificity, and molecular analysis (KRAS, GNAS, and KRAS + GNAS mutations) showed a high specificity but low sensitivity for diagnosing mucinous PCLs. Satisfactory results were not obtained during the evaluation of the efficiency of pancreatic cyst fluid (PCF) biomarkers in detecting malignant PCLs.

DISCUSSION:
For centers with relevant expertise and facilities, EUS-TTNB and EUS-nCLE were better choices for the diagnosis of PCLs. Further studies are urgently required for further improving PCF biomarkers and validating the diagnostic performance of the index techniques.
Can a Solitary Juvenile Polyp Be Regarded as a Nonmalignant Polyp?
Authors: Fukami Kumiko , Furihata Makoto , Yano Shintaro , Okawa Hiroki , Nishi Shinjiro , Nakatsu Yoichi , Nomoto Yusuke , Ogiwara Shingo , Kitamura Tsuneo , Tomita Shigeki , Osada Taro 
Published: December 2022

ABSTRACT
Juvenile polyps (JPs) are common, developing mostly as solitary, hamartomatous lesions in the colorectum, and principally affect pediatric patients. Solitary JPs are recognized as benign, with a negligible malignant transformation rate. Primary signet ring cell carcinoma is a rare type of colorectal cancer (0.1%–2.6%) that presents mostly at an advanced stage in younger patients and affects the right-sided colon, with extensive lymphatic invasion and peritoneal dissemination, resulting in a poorer prognosis compared with conventional colorectal cancer. We report a rare case of signet ring cell carcinoma in a solitary JP treated with endoscopic mucosal resection.
Against Gender: The Anti-Gender Movements and the Socio-Cultural and Moral Deconstructions in Europe
Authors: Matejková Alexandra , Mihálik Jaroslav 
Published: December 2022

Abstract

Gender ideology has quickly developed as a response to fostering human rights, especially in the case of gender equality. Gender policy thus became a political and ideological instrument that subjects human rights to another contest – a new form of crusade pursued by anti-gender movements which advocate traditional and conservative ideologies against gender equality and gender theories. In this paper, we seek to track and map the recent development of anti-gender movements and their mobilisation. We apply critical discourse analysis to several doctrines of antigenderism in order to understand the global popularity and mass appeal of these movements.
Philosophical Inquiry into Computer Intentionality: Machine Learning and Value Sensitive Design
Authors: Mykhailov Dmytro 
Published: December 2022

Abstract
Intelligent algorithms together with various machine learning techniques hold a dominant position among major challenges for contemporary value sensitive design. Self-learning capabilities of current AI applications blur the causal link between programmer and computer behavior. This creates a vital challenge for the design, development and implementation of digital technologies nowadays. This paper seeks to provide an account of this challenge. The main question that shapes the current analysis is the following: What conceptual tools can be developed within the value sensitive design school of thought for evaluating machine learning algorithms where the causal relation between designers and the behavior of their computer systems has been eroded? The answer to this question will be provided through two levels of investigation within the value sensitive design methodology. The first level is conceptual. Within the conceptual level, we will introduce the notion of computer intentionality and will show how this term may be used for solving an issue of non-causal relation between designer and computer system. The second level of investigation is technical. At this level the emphasis will be given to machine learning algorithms.
Performance analysis of the hybrid MIMO-LD/LED link for the UWOC system in sea water
Authors: Abd Mertah N. , Ali Mazin Ali A. , Mohammed Nadheer J. 
Published: December 2022

Abstract
Theoretical analysis of underwater wireless optical communications (UWOC) systems based on a hybrid LD/LED link in sea water was reported in this research. Multiple input-multiple output (MIMO) and single input-single output (SISO) approaches are used to implement the modulation schemes NRZ-OOK, RZ-OOK, 4-QAM, and 64-PPM. As carriers, waves with the wavelengths 715, 650, 532, and 412 nm are employed. The receiver unit includes the photodiodes PIN and APD to recognize the received signal. The findings indicate that the hybrid LD/LED link’s performance using the MIMO technique is superior to SISO in terms of BER, Q factor, and data rate. Additionally, 64-PPM is a reliable modulation technique for achieving a low BER and a high Q factor.
Phragmén-Lindelöf alternative results and structural stability for Brinkman fluid in porous media in a semi-infinite cylinder
Authors: Li Yuanfei , Chen Xuejiao 
Published: December 2022

Abstract
This article investigates the spatial behavior of the solutions of the Brinkman equations in a semi-infinite cylinder. We no longer require the solutions to satisfy any a priori assumptions at infinity. Using the energy estimation method and the differential inequality technology, the differential inequality about the solutions is derived. By solving this differential inequality, it is proved that the solutions grow polynomially or decay exponentially with spatial variables. In the case of decay, the structural stability of Brinkman fluid is also proved.
A Boat Is a Boat Is a Boat…Unless It Is a Horse – Rethinking the Role of Typology
Authors: Horn Christian , Green Ashely , Skärström Victor Wåhlstrand , Lindhé Cecilia , Peternell Mark , Ling Johan 
Published: December 2022

Abstract
Today, it is widely accepted that typology is a biased and inconsistent attempt to classify archaeological material based on the similarity of a predefined set of features. In this respect, machine learning (ML) works similar to typology. ML approaches are often deployed because it is thought that they reduce biases. However, biases are introduced into the process at many points, e.g., feature selection. In a project applying ML to Scandinavian rock art data, it was noticed that the algorithm struggles with classifying certain motifs correctly. This contribution discusses the consistency in applying biases by ML in contrast to the inconsistency of human classification. It is argued that it is necessary to bring machines and humans into a meaningful dialogue attempting to understand why apparent “misclassifications” happen. This is important to inform us about the classification output, our biases, and the rock art data, which are in themself inconsistent, ambiguous, and biased because they are the outcomes of human creativity. The human inconsistency is a necessary component because in rock art not everything that looks similar has a similar meaning.
Eco-friendly flaxseed mucilage biofilms fabricated by gamma irradiation
Authors: Raslan Heba A. , Sokary Rehab 
Published: December 2022

Abstract
With looming the global energy crisis and environmental problems Biodegradable green blends based on natural resources and biodegradable polymers have increasingly attracted many researches interest due to their advantages of low cost, use of renewable resource, and biodegradability. In this study, flaxseed mucilage (FM) was extracted with distilled water and utilised to make films with varying ratios of polyvinyl alcohol (PVA) and chitosan (Cs). Gamma irradiation was used as green method to improve the performance of the produced films. Then the films were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), UV–vis spectrophotometry and XRD analysis. The tensile measurements, moisture content were used to evaluate the films’ qualities. When flaxseed mucilage is mixed with PVA/Cs blend, it forms films that are less resistive, less rigid, and more flexible, improves mechanical properties and thermal stability. Films containing mucilage and PVA/Cs blend exhibited a compact and homogeneous structure under SEM, confirming the FTIR spectra that suggested a chemical interaction between these three biopolymers. Based on all above properties of the developed films, it can be envisaged to use these films for packaging applications.
Theoretical analysis of interfacial design and thermal conductivity in graphite flakes/Al composites with various interfacial coatings
Authors: Liu Yuan , Li Wenjun , Cui Yan , Yang Yukun , Yang Jipeng 
Published: December 2022

Abstract
Graphite flakes/Al composites are promising thermal management materials due to high thermal conductivity (TC) in basal plane orientation, matched coefficient of thermal expansion, and good machinability. In this article, the acoustic mismatch model and the effective medium approach are applied to predict the influence of different interfacial coatings on the interfacial thermal conductance (ITC) and the TC of graphite flakes/Al composites, respectively. With the increase in the thickness of interfacial coatings, the ITC and the TC of graphite flakes/Al composites decrease. For the composites with Ni, Cr/Cr7C3/Cr3C2, Si/SiC, Ti/TiC, WC, and Mo/Mo2C coatings, the ITC is sensitive to coating thickness. In order to obtain ideal TC of graphite flakes/Al composites, the thickness of the coatings should be controlled below 1 μm. It is reasonable that the TC of the graphite flakes/Al composites increases as the volume fraction of graphite flakes increases. The TC of the graphite flakes/Al composites increases with the ITC and changes slowly when the ITC increases to a certain extent. Si/SiC and WC coatings are proposed to be the most promising candidates to improve the thermal performance of graphite flakes/Al composites.
Specific Inhibition of Interpeduncular Nucleus GABAergic Neurons Alleviates Anxiety-Like Behaviors in Male Mice after Prolonged Abstinence from Methamphetamine
Authors: Xu Xing , Li Nanqin , Wen Jun , Yang Ping , Lu Xue , Wang Zilin , He Teng , Fan Yu , Xu Bo , Ge Feifei , Guan Xiaowei 
Published: December 2022

Anxiety is one of the most common withdrawal symptoms of methamphetamine (METH) abuse, which further drives relapse to drugs. Interpeduncular nucleus (IPN) has been implicated in anxiety-like behaviors and addiction, yet its role in METH-abstinence-induced anxiety remains unknown. Here, we found that prolonged abstinence from METH enhanced anxiety-like behaviors in male mice, accompanied by more excited IPN GABAergic neurons, as indicated by the increased c-fosexpression and the enhanced neuronal excitability by electrophysiological recording in the GABAergic neurons. Using the designer receptors exclusively activated by designer drugs method, specific inhibition of IPN GABAergic neurons rescued the aberrant neuronal excitation of IPN GABAergic neurons and efficiently reduced anxiety-like behaviors, whereas it did not induce depression-like behaviors in male mice after prolonged abstinence from METH. These findings reveal that IPN GABAergic neurons should be a promising brain target to alleviate late withdrawal symptoms from METH with few side effects.SIGNIFICANCE STATEMENTProlonged abstinence from METH triggers IPN GABAergic neurons and ultimately increases anxiety in male mice. Suppressing IPN GABAergic neurons rescues METH abstinence-induced aberrant neuronal excitation of IPN GABAergic neurons and efficiently reduces anxiety in mice.
Implementation of Federalism in Nepal: The Devil is in the Detail
Authors: Smith Robert Brian , Smith Nucharee Nuchkoom 
Published: December 2022

After a long period of instability, Nepal adopted a new Constitution in 2015, creating a multiparty federal republic. Previously Nepal had been a unitary state, albeit with a long period of political instability and insurgencies. In 2017 the two competing communist parties merged to form the ruling Nepal Communist Party (NCP), which operated with a 2/3rd majority in the House of Representatives. The implementation of federalism has been slow and uneven. Despite assurances to the contrary, the government’s response to the COVID-19 pandemic has been lacking, with Constitutional obligations ignored. The machinations of the then Prime Minister have exacerbated this, apparently supported by the President to overcome constitutional norms to keep the Prime Minister in power. The paper analyses the devolution of powers to the provincial and local levels described in the constitution. There have been successes and failures. There appeared to be a concerted effort from the federal parliament and some in the bureaucracy to continue to centralize power. This early inaction has hindered its response to the pandemic. Of even more concern is the then prime minister's role as he sought to maintain his hold on power by ignoring the provisions of the Constitution.
Rethinking Indebtedness according to the Principles of Justice and Equality
Authors: Johan Suwinto , Sudiro Amad , Gunadi Ariawan , Luo Yuan Yuan 
Published: December 2022

The law's objective is to uphold the principle of justice. Contractual debts, interest-bearing debts, unsecured debts, and debts with payment terms are all included in restructuring plans. All debts must be accompanied by a contract. If the business defaults, the contract serves as proof of debt. This research focuses on Indonesia's bankruptcy law. This study employs an empirical qualitative legal method. The study recommends categorizing debt according to its source, duration, function, and collateral. Debts classified as restructuring must waive their collateral rights. This debt grouping is consistent with finance's capital structure theory. This research will revolutionize the current concept of debt restructuring. The study will serve as a resource for all business actors who have documented debt. Debt is uncommon in developing countries such as Indonesia. Entrepreneurs in developing countries have established business relationships based on mutual trust. The study's limitation is that it does not take industry type into account. Additionally, this research has implications for a firm's total cost of capital as a result of changes in the risk model and creditor roles, particularly in developing countries. This study proposes a system of debt classification based on principles of justice and equity. This classification is made not only on the basis of the guarantee's type, but also on the basis of the agreement's duration and financial principles. The purpose of this study is to examine bankruptcy law in developing countries. Knowledge of bankruptcy law will add value to investors and banks on a global scale.
Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitis
Authors: He Weiwei , Huang Caoxin , Shi Xiulin , Wu Menghua , Li Han , Liu Qiuhong , Zhang Xiaofang , Zhao Yan , Li Xuejun 
Published: December 2022

Background
Fibrosis is an important pathological process in the development of non-alcoholic steatohepatitis (NASH), and the activation of hepatic stellate cell (HSC) is a central event in liver fibrosis. However, the transcriptomic change of activated HSCs (aHSCs) and resting HSCs (rHSCs) in NASH patients has not been assessed. This study aimed to identify transcriptomic signature of HSCs during the development of NASH and the underlying key functional pathways.

Methods
NASH-associated transcriptomic change of HSCs was defined by single-cell RNA-sequencing (scRNA-seq) analysis, and those top upregulated genes were identified as NASH-associated transcriptomic signatures. Those functional pathways involved in the NASH-associated transcriptomic change of aHSCs were explored by weighted gene co-expression network analysis (WGCNA) and functional enrichment analyses. Key regulators were explored by upstream regulator analysis and transcription factor enrichment analysis.

Results
scRNA-seq analysis identified numerous differentially expressed genes in both rHSCs and aHSCs between NASH patients and healthy controls. Both scRNA-seq analysis and in-vivo experiments showed the existence of rHSCs (mainly expressing a-SMA) in the normal liver and the increased aHSCs (mainly expressing collagen 1) in the fibrosis liver tissues. NASH-associated transcriptomic signature of rHSC (NASHrHSCsignature) and NASH-associated transcriptomic signature of aHSC (NASHaHSCsignature) were identified. WGCNA revealed the main pathways correlated with the transcriptomic change of aHSCs. Several key upstream regulators and transcription factors for determining the functional change of aHSCs in NASH were identified.

Conclusion
This study developed a useful transcriptomic signature with the potential in assessing fibrosis severity in the development of NASH. This study also identified the main pathways in the activation of HSCs during the development of NASH.
OKLUZAL SPLİNTLERİN AĞIZ HİJYENİ VE DİŞ ETİ ÜZERİNE ETKİSİNİN İNCELENMESİ
Authors: SARİ Oğuzhan , YANIKOĞLU Nuran , UYTUN Mehmetcan 
Published: December 2022

Amaç: Özellikle bruksizim tedavisinde kullanılan okluzal splintler hastaların ağız bakımını ve tükürüğün yıkama etkisini değiştirebilmektedir. Yaptığımız çalışmanın amacı ise, bu değişikliklerin diş ve çevre gingival dokulara etkisini incelemektir.
Gereç ve Yöntem: Çalışma bruksizm şikayeti olan 50 hasta üzerinde yapılmıştır. 43 hasta takip randevularına gelmiştir. Hastanın plak kullanımına başlamadan hemen önce, plak kullanımına başladıktan sonra ise 1. ve 3. aylarda diş eti ölçümleri yapılmıştır. Çalışmada plak indeksi, gingival indeksi ve kanama indeksleri değerlendirilmiştir. Veriler IBM SPSS V23 programı ile analiz edilmişitir.
Bulgular: Çalışma sonuçlarına göre plak kullanımı sonrası plak indeksinde azalma olduğu görülmüştür. Gingival indeks ve kanama indeksinde anlamlı bir farklılık görülmemiştir. Çalışma sonuçları farklı dişlere göre değerlendirildiğinde ise sadece maksiller sağ birinci molar dişin plak indeksinde bir azalma görülmüştür. Diğer dişlerde plak, gingival ve kanama indekslerinde anlamlı fark bulunamamıştır.
Sonuç: Okluzal splint kullanımı, oral hijyen eğitimi, klinik takipler hastanın ağız bakımında olumlu alışkanlıklar kazandırarak ağız hijyenini olumlu yönde etkilemiştir.