bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of Sodium Hyaluronate, Withania Somnifera Extract and
Niacinamide Improves Hydration and Skin Tone – A Clinical Study
Authors: Rastogi Rachna , Lima Galwin D , Gholap Anjali 
Published: August 2023

Background:
Multiple moisturizing solutions with sodium hyaluronate, Withania sominifera, and niacinamide are commercially popular. Detailed clinical studies portraying their activity are not available.

Objective:
This study aims to study the clinical efficacy of a phyto-bioactive cream in improving skin hydration and tone with 4 weeks of continuous usage.

Methodology:
We conducted a non-comparative, single-blind study on 50 Asian female volunteers with Fitzpatrick skin types III and IV for 28 days. Cosmetic acceptability and safety of the product were established via self-evaluation questionnaires. The ability of the topical formulation in maintaining skin tone, hydration, and firmness was determined by instrumental analysis and smoothness by dermatologist evaluation.

Results:
A total of 46 subjects completed the study. High levels of skin hydration were noted instantaneously (+61.11%) and post continuous use of the product. Significant reduction in the appearance of age/dark spots (ITA°), Δ ITA°= 37.49% and increase in skin lightness (L) by 2.66% compared to baseline was observed in 4 weeks. More than 80% of the subjects reported an increase in skin firmness and smoothness in 4 weeks of twice-a-day product usage.

Conclusion:
Our study establishes the safety and acceptability of the phyto-bioactive cream. The efficiency of the combination of Withania somnifera extract, sodium hyaluronate, and niacinamide in improving skin hydration and tone has been proven.
HIV Prevention and Treatment Interventions for Black Men Who Have Sex With Men in Canada: Scoping Systematic Review
Authors: Demeke Jemal , Djiadeu Pascal , Yusuf Abban , Whitfield Darren Lovell , Lightfoot David , Worku Fiqir , Abu-Ba'are Gamji Rabiu , Mbuagbaw Lawrence , Giwa Sulaimon , Nelson LaRon E 
Published: August 2023

Background
Black men who have sex with men (MSM) experience disproportionately high HIV incidence globally. A comprehensive, intersectional approach (race, gender, and sexuality or sexual behavior) in understanding the experiences of Black MSM in Canada along the HIV prevention and care continuums has yet to be explored.

Objective
This scoping review aims to examine the available evidence on the access, quality, gaps, facilitators, and barriers of engagement and identify interventions relevant to the HIV prevention and care continuum for Black MSM in Canada.

Methods
We conducted a systematic database search, in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist, of the available studies on HIV health experience and epidemiology concerning Black MSM living with or without HIV in Canada and were published after 1983 in either English or French. Searched databases include MEDLINE, Excerpta, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, the NHUS Economic Development Database, Global Health, PsycInfo, PubMed, Scopus, and Web of Science. From the 3095 articles identified, 19 met the inclusion criteria and were analyzed.

Results
Black MSM in Canada consistently report multiple forms of stigma and lack of community support contributing to an increased HIV burden. They experience discrimination based on their intersectional identities while accessing HIV preventative and treatment interventions. Available data demonstrate that Black MSM have higher HIV incidences than Black men who have sex with women (MSW) and White MSM, and low preexposure prophylaxis knowledge and HIV literacy. Black MSM experience significant disparities in HIV prevention and care knowledge, access, and use. Structural barriers, including anti-Black racism, homophobia, and xenophobia, are responsible for gaps in HIV prevention and care continuums, poor quality of care and linkage to HIV services, as well as a higher incidence of HIV.

Conclusions
Considering the lack of targeted interventions, there is a clear need for interventions that reduce HIV diagnoses among Black MSM, increase access and reduce structural barriers that significantly affect the ability of Black MSM to engage with HIV prevention and care, and address provider’s capacity for care and the structural barriers. These findings can inform future interventions, programming, and tools that may alleviate this HIV inequity.

International Registered Report Identifier (IRRID)
RR2-10.1136/bmjopen-2020-043055
Mortality Risk and Burden From a Spectrum of Causes in Relation to Size-Fractionated Particulate Matters: Time Series Analysis
Authors: Yang Jun , Dong Hang , Yu Chao , Li Bixia , Lin Guozhen , Chen Sujuan , Cai Dongjie , Huang Lin , Wang Boguang , Li Mengmeng 
Published: August 2023

Background
There is limited evidence regarding the adverse impact of particulate matters (PMs) on multiple body systems from both epidemiological and mechanistic studies. The association between size-fractionated PMs and mortality risk, as well as the burden of a whole spectrum of causes of death, remains poorly characterized.

Objective
We aimed to examine the wide range of susceptible diseases affected by different sizes of PMs. We also assessed the association between PMs with an aerodynamic diameter less than 1 µm (PM1), 2.5 µm (PM2.5), and 10 µm (PM10) and deaths from 36 causes in Guangzhou, China.

Methods
Daily data were obtained on cause-specific mortality, PMs, and meteorology from 2014 to 2016. A time-stratified case-crossover approach was applied to estimate the risk and burden of cause-specific mortality attributable to PMs after adjusting for potential confounding variables, such as long-term trend and seasonality, relative humidity, temperature, air pressure, and public holidays. Stratification analyses were further conducted to explore the potential modification effects of season and demographic characteristics (eg, gender and age). We also assessed the reduction in mortality achieved by meeting the new air quality guidelines set by the World Health Organization (WHO).

Results
Positive and monotonic associations were generally observed between PMs and mortality. For every 10 μg/m3 increase in 4-day moving average concentrations of PM1, PM2.5, and PM10, the risk of all-cause mortality increased by 2.00% (95% CI 1.08%-2.92%), 1.54% (95% CI 0.93%-2.16%), and 1.38% (95% CI 0.95%-1.82%), respectively. Significant effects of size-fractionated PMs were observed for deaths attributed to nonaccidental causes, cardiovascular disease, respiratory disease, neoplasms, chronic rheumatic heart diseases, hypertensive diseases, cerebrovascular diseases, stroke, influenza, and pneumonia. If daily concentrations of PM1, PM2.5, and PM10 reached the WHO target levels of 10, 15, and 45 μg/m3, 7921 (95% empirical CI [eCI] 4454-11,206), 8303 (95% eCI 5063-11,248), and 8326 (95% eCI 5980-10690) deaths could be prevented, respectively. The effect estimates of PMs were relatively higher during hot months, among female individuals, and among those aged 85 years and older, although the differences between subgroups were not statistically significant.

Conclusions
We observed positive and monotonical exposure-response curves between PMs and deaths from several diseases. The effect of PM1 was stronger on mortality than that of PM2.5 and PM10. A substantial number of premature deaths could be preventable by adhering to the WHO’s new guidelines for PMs. Our findings highlight the importance of a size-based strategy in controlling PMs and managing their health impact.
Blueberry extract for the treatment of ischemic stroke through regulating the gut microbiota and kynurenine metabolism
Authors: wang raoqiong , Huang Guoxin , Li Shuangyang , Huang Hanlin , Zhu Guo-Yuan , Wang Liang , Yang Jinrui , Yang Sijin , Jiang Zhihong , zhang wei 
Published: August 2023

Background and purpose Although the gut microbiota and its metabolites
have significant protective effects against ischemic stroke(IS), the
exact mechanism has yet to be fully elucidated. In this study,the
function of intestinal microecology-kynurenine metabolism has been
explored in IS rats and patients,which could help us deeply to
understand the role of microbiota in the gut-brain axis. Experimental
approach Combined serum metabolomics and 16S rRNA gene sequencing were
used to reveal the distinctive changes between the gut microbiota and
metabolites in rats with or without blueberry extract.Fecal microbiota
transplantation(FMT) was employed to validate the protective role of gut
microbiota in IS. Furthermore, the interaction between Prevotella and IS
was also confirmed in patients. Key results A positive correlation
between Prevotella and kynurenine (KYN) was obtained in IS rats.
Although the study highlighted that KYN and its metabolites were
strongly activated, the 5-HT pathway was not significantly altered.An
intervention with Prevotella also significantly improved stroke symptoms
by enhancing intestinal barrier function and attenuating the
inflammatory response and decreased KYN levels in IS rats.FMT provided
more evidences to support that the beneficial effects of blueberry
extract on IS involved gut bacteria,especially Prevotella, which have
been confirmed by microbiological analyses conducted on IS
patients.Moreover, blueberry extract led to significant changes in
kynurenic acid,tryptophan and indoleamine 2,3-dioxygenase protein
through the interaction with Prevotella. Conclusion and implications Our
study demonstrates for the first time that Prevotella and kynurenine
metabolism play important roles in brain-gut signaling.And blueberry
extract could modulate “intestinal microecology-kynurenine metabolism”
to improve IS.
Silybin acts synergistically with mesenchymal stem cells to ameliorate R848-induced lupus-like disease in mice
Authors: Zhao Nan , Abdukiyum Miheraiy , Zheng Yuanyuan , Li wenjing , Huang Mengxi , Li Mei , Alim Tohtihan , Cui Yiyuan , Ying Xie , Tang Xiaojun , Feng Xuebing 
Published: August 2023

Objective: To determine the therapeutic effects of silybin (SBI) and its
synergistic effects with mesenchymal stem cells (MSCs) in a lupus mouse
model and to explore the therapeutic mechanisms. Methods: TLR7/8 agonist
resiquimod (R848) was applied for the induction of lupus mice.
R848-induced B6 mice were randomly divided into a normal saline control
group, SBI group, MSCs group, and SBI plus MSCs group, and treated with
daily SBI by gavage or received MSCs injection once via the tail vein.
Mice were sacrificed at week 12, with urine, serum, kidney, and spleen
collected. The proportion of cell subsets was detected by flow cytometry
using splenocytes. Results: SBI treatment significantly decreased total
IgG, anti-ds-DNA antibody, and urinary protein levels, as well as renal
IgG and C3 deposition in R848-induced mice. It also increased the
ability of MSCs to suppress splenomegaly and serum antinuclear antibody
levels. In vivo and in vitro studies showed a decrease in the percentage
of Tfh cells after SBI treatment, which was most pronounced when
combined with MSC therapy. When splenocytes of R848-induced mice were
treated with SBI and MSCs in vitro, the expression of genes related to
Tfh cell differentiation, including IL-6, Stat3, and Bcl-6, was reduced,
and the phosphorylation of AKT, S6, and STAT3 proteins in Tfh cells was
decreased. Conclusion: SBI acts synergistically with MSCs to ameliorate
lupus-like features in R848-induced mice. It may enhance the ability of
MSCs to inhibit Tfh cell production by counteracting the activation of
IL-6 and its downstream pathways.
Randomization to a Provided Higher-Complex-Carbohydrate Versus Conventional Diet in Gestational Diabetes Mellitus Results in Similar Newborn Adiposity
Authors: Hernandez Teri L. , Farabi Sarah S. , Fosdick Bailey K. , Hirsch Nicole , Dunn Emily Z. , Rolloff Kristy , Corbett John P. , Haugen Elizabeth , Marden Tyson , Higgins Janine , Friedman Jacob E. , Barbour Linda A. 
Published: August 2023

OBJECTIVE
Nutrition therapy for gestational diabetes mellitus (GDM) has conventionally focused on carbohydrate restriction. In a randomized controlled trial (RCT), we tested the hypothesis that a diet (all meals provided) with liberalized complex carbohydrate (60%) and lower fat (25%) (CHOICE diet) could improve maternal insulin resistance and 24-h glycemia, resulting in reduced newborn adiposity (NB%fat; powered outcome) versus a conventional lower-carbohydrate (40%) and higher-fat (45%) (LC/CONV) diet.

RESEARCH DESIGN AND METHODS
After diagnosis (at ∼28–30 weeks’ gestation), 59 women with diet-controlled GDM (mean ± SEM; BMI 32 ± 1 kg/m2) were randomized to a provided LC/CONV or CHOICE diet (BMI-matched calories) through delivery. At 30–31 and 36–37 weeks of gestation, a 2-h, 75-g oral glucose tolerance test (OGTT) was performed and a continuous glucose monitor (CGM) was worn for 72 h. Cord blood samples were collected at delivery. NB%fat was measured by air displacement plethysmography (13.4 ± 0.4 days).

RESULTS
There were 23 women per group (LC/CONV [214 g/day carbohydrate] and CHOICE [316 g/day carbohydrate]). For LC/CONV and CHOICE, respectively (mean ± SEM), NB%fat (10.1 ± 1 vs. 10.5 ± 1), birth weight (3,303 ± 98 vs. 3,293 ± 81 g), and cord C-peptide levels were not different. Weight gain, physical activity, and gestational age at delivery were similar. At 36–37 weeks of gestation, CGM fasting (86 ± 3 vs. 90 ± 3 mg/dL), 1-h postprandial (119 ± 3 vs. 117 ± 3 mg/dL), 2-h postprandial (106 ± 3 vs. 108 ± 3 mg/dL), percent time in range (%TIR; 92 ± 1 vs. 91 ± 1), and 24-h glucose area under the curve values were similar between diets. The %time &gt;120 mg/dL was statistically higher (8%) in CHOICE, as was the nocturnal glucose AUC; however, nocturnal %TIR (63–100 mg/dL) was not different. There were no between-group differences in OGTT glucose and insulin levels at 36–37 weeks of gestation.

CONCLUSIONS
A ∼100 g/day difference in carbohydrate intake did not result in between-group differences in NB%fat, cord C-peptide level, maternal 24-h glycemia, %TIR, or insulin resistance indices in diet-controlled GDM.
<strong>Methyl donor nutrient intake and incidence of type 2 diabetes mellitus: results from 3 large US cohorts</strong>
Authors: Sawicki Caleigh M. , Haslam Danielle E. , V.E. Braun Kim , Drouin-Chartier Jean-Philippe , Voortman Trudy , Franco Oscar H. , Sun Qi , Hu Frank B. , Bhupathiraju Shilpa N. 
Published: August 2023

<p> </p>
<p><em>Objective:</em> We examined whether intake of methyl donor nutrients, including vitamins B2, B6, and B12, and folate, from foods and/or supplements is associated with type 2 diabetes risk.</p>
<p><em>Design and Methods:</em> We included 203,644 women and men from the Nurses' Health Study (1984-2016), Nurses' Health Study 2 (1991-2017), and Health Professionals Follow-Up Study (1986-2016). Dietary data were collected every 2-4 years using semi-quantitative food frequency questionnaires. Cox proportional hazards models with time-varying covariates were used to evaluate associations between each nutrient and type 2 diabetes risk. Cohort-specific hazard ratios were combined using inverse variance-weighted fixed effects meta-analyses.</p>
<p><em>Results:</em> During 4,900,181 person-years of follow-up, we documented 19,475 incident type 2 diabetes cases. In multivariable-adjusted meta-analyses, participants in the highest quintile of total vitamin B2 and B6 intakes had lower risk of diabetes compared with those in the lowest quintile [HR(95% CI): 0.93(0.89, 0.98) for B2; 0.93(0.89, 0.97) for B6]. When stratified by source, significant associations remained for B2 from food, but not from supplements. Neither association for B6 from food or supplements attained significance. No association was observed between total B12 intake and diabetes. However, B12 from food was marginally associated with a higher diabetes risk [HR(95% CI): 1.05(1.00-1.11)], but not after additional adjustment for red meat intake [HR(95% CI): 1.04(0.99-1.10)]. No evidence of association was observed between intakes of folate and diabetes.</p>
<p><em>Conclusions:</em> Our study suggests that higher intake of vitamin B2 and B6, especially B2 from food sources, may be associated with a modestly lower type 2 diabetes risk.</p>
Effect of sodium-glucose cotransporter 2 inhibitors on left atrial remodeling and prognosis in patients with type 2 diabetes and heart failure with reduced ejection fraction
Authors: Yu Songqi , Sun Yuxi , Wang Ning , Lv Xin , Si Jinping , Zhang Xinxin , Zhang Yanli , Liu Ying 
Published: August 2023

Aims
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been found to minimize hospitalization for heart failure and cardiovascular death. Cardiac reverse remodeling may be a mechanism responsible for the favorable clinical efficacy of SGLT2is on heart failure. To date, few studies have examined their effects on the left atrium. Therefore, the purpose of this study was to explore whether SGLT2is improve left atrial adverse remodeling in patients with type 2 diabetes and heart failure with reduced ejection fraction (HFrEF).

Methods
A single-center, retrospective, observational study was conducted. Consecutive patients with type 2 diabetes and HFrEF hospitalized at the First Affiliated Hospital of Dalian Medical University for acute decompensated heart failure between 1 January 2019 and 1 March 2022 were identified. On the basis of their treatment strategies, the enrolled participants were classified into SGLT2i and non-SGLT2i groups. The primary end point was all-cause mortality. Changes in left atrial echocardiographic indices from baseline to follow-up were also assessed.

Results
A total of 198 patients (mean age: 63.96 ± 12.11 years, 20.71% women) were included. Greater reductions from baseline were seen with SGLT2i in the left atrial diameter (P < 0.001), left atrial superior–inferior diameter (P = 0.027), left atrial transverse diameter (P = 0.020), left atrial volume (P = 0.005), and left atrial volume index (P = 0.004). Moreover, 48 cases (48.48%) in the SGLT2i group and 33 (33.33%) in the non-SGLT2i group showed left atrial reverse remodeling (P = 0.003). Survival analysis demonstrated significantly lower overall mortality in the SGLT2i group compared with the non-SGLT2i group.

Conclusion
This study found that SGLT2i therapy promoted left atrial structure reverse remodeling. This beneficial effect may be a vital mechanism by which SGLT2i improved clinical outcomes in patients with HFrEF.
Prognostic impact of red blood cell distribution width in chronic heart failure patients with left ventricular dysfunction
Authors: Ferreira Ana Isabel , Silva João Enes , Melo Nuno , Oliveira Diana , Silva Clara , Lume Maria , Pereira Joana , Almeida Jorge , Araújo José Paulo , Lourenço Patrícia 
Published: August 2023

Aims
Red blood cell (RBC) distribution width (RDW) measures RBC variations in size. Higher RDW values have been associated with poor outcome in acute heart failure (HF). We aimed to assess the prognostic impact of the RDW in chronic HF.

Methods
We retrospectively analysed a cohort of chronic HF patients with left ventricular systolic dysfunction followed in our HF clinic between January 2012 and May 2018. Patients with missing data concerning RDW were excluded. Patients were categorized according to RDW tertiles: ≤13.5%; between 13.5 and 14.7%; and >14.7%. Patients were followed until January 2021; all-cause mortality was the end point analysed. The association of RDW with all-cause mortality was assessed with a Cox-regression analysis. Two multivariate models were built.

Results
We studied 860 chronic HF patients, 66.4% males, mean age 70 (standard deviation, SD 13) years. Patients were followed for a median of 49 (29–82) months. During this period, 423 (49.2%) patients died. Mortality increased with increasing RDW tertiles. Patients with RDW >14.7% had a HR of mortality of 1.95 (1.47–2.58), p < 0.001 (model 1) and of 1.81 (1.35–2.41), p < 0.001 (model 2) when compared with those with RDW ≤13.5. Patients in the second RDW tertile had an all-cause death HR of 1.47 (1.12–1.93) and of 1.44 (1.09–1.90) in models 1 and 2, respectively.

Conclusions
Chronic HF patients with RDW values >14.7% presented an almost 2-fold higher risk of dying in the long term than those with RDW <13.5%. RDW is a widely available and easily measured parameter that can help clinicians in the risk stratification of chronic HF patients.
Nilai Kehidupan Keluarga Sebagai Ide Penciptaan Karya Seni Grafis
Authors: Mustakim Ardian Bintang , Wulandari Wiwik Sri , Junaedi Deni 
Published: August 2023

ABSTRAKIde dan gagasan penciptaan karya jurnal ini mengambil dari nilai positif yang terjadi dalam kehidupan keluarga. Nilai yang diajarkan dari sikap dan prilaku orang tua dan dijelaskan oleh orang tua kepada anak agar nantinya dapat menjadi landasan kehidupan bagi anak. Nilai kehidupan yang diajarkan dalam lingkungan keluarga yaitu nilai tanggung jawab, nilai gotong royong, dan nilai toleransi. Nilai kehidupan ini yang menjadikan ide visualisasi penciptaan karya seni grafis dengan teknik silkscreen atau cetak saring yang dicetak pada media kertas. Meminjam bentuk dari suatu figur potret manusia dengan anatomi yang ideal dan penggambaran tanaman dan hewan yang ada dilingkungan sekitar dapat menambah kuat arti dari simbol visual dari sebuah nilai kehidupan yang terjadi dalam lingkungan keluarga. Sehingga dengan menciptakan karya seni grafis diharapkan dapat menjadi media renungan, pengingat serta memberi pencerahan bagi penulis maupun pembaca agar menjadi lebih baik lagi dalam memahami dan menjalani kehidupan dimasyarakat.Kata kunci : lingkungan keluarga, karakter anak, seni grafis ABSTRACTThe ideas and ideas for creating this journal work draw from the positive values that occur in family life. Values are taught from the attitudes and behavior of parents and explained by parents to children so that later they can become the foundation of life for children. The values of life that are taught in the family environment are the values of responsibility, the values of mutual cooperation, and the values of tolerance. This life value is what makes the idea of visualizing the creation of graphic artwork using silkscreen or filter printing techniques printed on paper media. Borrowing the form of a human portrait figure with ideal anatomy and the depiction of plants and animals in the surrounding environment can add a strong meaning to the visual symbol of a life value that occurs in the family environment. So that by creating works of graphic art it is hoped that they can become media for reflection, reminders and provide enlightenment for writers and readers so that they can better understand and live life in society.Keywords : Family environment, children's characters, printmaking.