bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outpatient-Polyclinic Register of the Multidisciplinary Medical Center (TERRA): general characteristics and first results
Authors: Lukyanov M. M. , Andreenko E. Yu. , Smirnov A. A. , Kudryavtseva M. M. , Kuzina N. N. , Klyashtorny V. G. , Shepel R. N. , Ryzhakova L. N. , Drapkina O. M. 
Published: July 2023

Aim. To describe the experience of creating the Outpatient-Polyclinic Register of the Multi-specialty Medical Center (TERRA) and the first results of the study.Material and methods. The TERRA registry included 32264 patients (age 44,0±15,3 years; 32,2% men) who applied to the multidisciplinary medical center from January 1, 2018 to December 31, 2021. Information from electronic outpatient records was evaluated. The data of patients with/without cardiovascular diseases (CVDs) in those who applied to general practitioners, cardiologists and other specialists, those with and without coronavirus disease 2019 (COVID-19) were compared.Results. There were 26,8% of patients with CVDs, while with ≥2 CVD — 8,1%, with CVD and/or chronic non-cardiac disease — 54,1%, their combination — 26%. Among those who consulted cardiologists, general practitioners and doctors of other specialties, hypertension was most often recorded — 64,8; 34,9 and 18,6%, coronary artery disease — 15,1, 6,2 and 3,2%, while from chronic non-cardiac diseases — diseases of the digestive system (64,4; 58,0 and 33,7%), kidneys (29,8; 24,9 and 13,2%), respiratory organs (28,4; 23,8 and 12,6%). The proportion of COVID-19 survivors was 8.2%, in patients with and without CVD — 14,8 and 5,1%, respectively (p<0,001). The proportion of CVD cases among survivors and non-survivors of COVID-19 was 58,0% and 25,2%, respectively (p<0,001). In addition, 88% of patients with CVDs consulted a cardiologist or general practitioner, of which 42% were observed by them together.Conclusion. The majority of patients at the multidisciplinary medical center had CVDs and chronic non-cardiac diseases, and more than a quarter had a combination of both. Patients with CVDs were more likely to have chronic non-cardiac diseases (2,2 times) and a history of COVID-19 (2,9 times). Among patients with a history of COVID-19, there was a higher proportion of cases of CVDs (by 2,3 times) and chronic non-cardiac pathology (by 1,8 times). Almost half of patients with CVD were observed jointly by a cardiologist and a general practitioner.
Ética, ecología y ecosofía
Authors: Osorio-García Sergio Néstor , Roberto Alba Nelson Fernando 
Published: July 2023

El texto busca ampliar las fronteras del concepto de “bioética global”, centro de la propuesta teórica de Van Rensselaer Potter sobre la “bioética ecológica” en su obra Global Bioethics, de cara a la “ética de la tierra” desarrollada por el ecólogo y ambientalista Aldo Leopold y el análisis de la “ecosofía” planteado por el filósofo y psicoanalista Félix Guattari en Las tres ecologías. Dicha caracterización se plantea con el fin de establecer presupuestos teóricos en torno a las nociones de bioética ecológica y ecosofía en la perspectiva de la bioética global en un renovado intento de ampliación de sus horizontes disciplinares. Se establecen tres momentos para el análisis: inicialmente se caracteriza la ética de la tierra propuesta por Arnold Leopold en su obra A Sand County Almanach. Posteriormente, se analizan los principales aspectos de la “ética ecológica” en la obra Global Bioethics. Finalmente, se destacan varios aspectos de la ecosofía de Félix Guattari que ponen en perspectiva el acento ecológico de la bioética global de Potter y que podrían ser considerados como presupuestos divergentes útiles para enriquecer la bioética global en la actualidad.
Unavoidable Practices for Effective Business Correspondence Teaching
Authors: CIBANGU MBAYA Patrice 
Published: July 2023

As a teacher of English as a Foreign Language in general and (the teacher) of English business correspondence in particular in Mbujimayi, I noticed fifth and six-year pupils’ weakness in business letter writing. Looking for weakness causes and how to achieve success, I have written this paper in order to make suggestions. Questionnaire and classroom observation have helped me to collect the data. The analytical and comparative methods have been used to find out whether what teachers do in class aligns with what is advocated by experts in the field. The study has revealed that 60% of the teachers said that the textbooks they use does not match with the criteria of contents and teaching approach while 40 % said the textbooks do. 80% of the teachers use samples of letters for reading activities while 20% said they do not. 80% of the teachers said pupils usually write letters at home but sometimes in class while 20% said their pupils usually write letters at home but sometimes at home. 100% of the teachers teach business correspondence as a theory course, not like a practical writing class. 100% of the teachers said pupils have vocabulary problems. In terms of suggestions to remedy this situation, the following unavoidable practices can help to achieve learner success in this field: (1) Learners’ Needs Analysis, Material Adaptation and Simulation, (2) Learner-centeredness in English Commercial Correspondence Teaching, (3) Vocabulary and Reading prior to Letter Writing, (4) Repetitive Pupils’ Work under the Teacher’s Supervision.
Reconstructing a Patellar Tendon Rupture Neglected for 14 Years When Anatomic Restoration Is Not Possible
Authors: Jurgensmeier Kevin , Kweon Christopher Y 
Published: July 2023

Case:
This case highlights the utility and outcomes of an Achilles tendon bone-block allograft in reconstructing the patellar tendon of a 44-year-old man in the setting of a high-riding, irreducible patella after a chronic patellar tendon rupture of 14 years.

Conclusion:
In cases of a neglected patellar tendon rupture with an irreducible high-riding patella, an Achilles tendon bone-block allograft can provide the length and tissue necessary to reconstruct the extensor mechanism. Although reconstruction may not be anatomic, patients can still experience great subjective and objective functional improvement with restoration of the extensor mechanism even after delayed reconstruction.
Thoracic Spine Fracture After Cardiopulmonary Resuscitation in a Patient with Ankylosing Spondylitis
Authors: de los Cobos Daniel , Nwadike Benjamin A. , Padhye Kedar 
Published: July 2023

Case:
A 32-year-old man with a history of ankylosing spondylitis presented to the emergency department because of sepsis secondary to Fournier’s gangrene and subsequently went into cardiac arrest requiring cardiopulmonary resuscitation (CPR). On the twelfth hospital day, a fracture through the T5-T6 intervertebral disk space was incidentally found on a chest, abdominal, and pelvic Computed Tomography (CT) scan. The rounds of CPR were the only traumatic event that the patient underwent before the discovery of the spine fracture.

Conclusion:
A low threshold for advanced imaging should be held to rule out occult spine fractures in patients with ankylosed spines after receiving CPR.
The causal effect between gut microbiota and sarcopenia related traits: A large-scale bidirectional Mendelian randomization
Authors: Fu weili , Xu Tianhao , Zhang Lei , Yang Xiaolong 
Published: July 2023

Abstract
Objective
The causal relationship between gut microbiota and sarcopenia remains unclear. The objective is to investigate the causal association between gut microbiota and sarcopenia related traits, including low hand grip strength (LHGS), appendicular lean mass (ALM), and usual walking speed (UWP), using two-sample Mendelian randomization (MR).
Design
Two sample Mendelian randomization study.
Setting and Participants
Genetic instruments predicting gut microbiota were from an existing genome-wide association study (GWAS) in 18,340 individuals (85% European descent). Summary data for LHGS (254,894 individuals), ALM ((487,378 individuals), and UWP (335,288 individuals) were respectively from different GWAS.
Methods
We selected genetic variants as instrumental variables for 211 taxa at different taxonomic levels and performed inverse variance weighting (IVW) to estimate the causal effects. We also conducted sensitivity analyses including heterogeneity and horizontal pleiotropy.
Results
We identified 7, 7, and 10 genetically predicted taxa that showed causal associations with LHGS, ALM, and UWP, respectively. Of these, family Alcaligenaceae, family Family XIII, family Streptococcaceae, genus Eubacterium brachy group, and genus Terrisporobacter were found to be genetically related to LHGS, family Bacteroidaceae, genus Bacteroides, genus Oscillospira, and genus Turicibacter are genetically associated with ALM, and family Veillonellaceae, genus Flavonifractor, genus Lachnospiraceae NC2004 group, genus Ruminococcaceae UCG010, and genus Actinomyces exhibited a genetic correlation with UWP. Sensitivity analysis shows that the above results do not violate the MR assumptions.
Conclusion
Our study provides novel evidence for the causal role of gut microbiota in sarcopenia. Modulating the gut microbiota may have potential implications for the prevention and treatment of sarcopenia.
a pathomic model to predict ifn-γ expression and patients’ survival in breast cancer: a machine learning-based study
Authors: Jiang Wenying , Gao Lanmei , Ni Jiulin , Li Shuting , Li Yueming , Xing Wei 
Published: July 2023

Abstract
Purpose
Breast cancer (BC) is the most popular malignancy. IFN-γ plays an important role in cancer immunity. This study is to predict IFN-γ expression in BC by digital pathology. Procedures: RNA-Seq data, pathological images, and clinical data from TCGA-BRCA were retrieved. Images were segmented by the OTSU algorithm and pathomic features were extracted via PyRadiomics. The cohort was randomly divided into the training and validation set as 7:3 ratios. The maximum relevance and minimum redundancy and recursive feature elimination algorithm were used to select the features. Then the prediction model was built by the Gradient Boosting Machine algorithm.
Results
IFN-γ was significantly up-regulated in BC (P < 0.001), and was an independent prognostic factor for OS (HR = 0.463, 95% CI 0.316 − 0.68). The IFN-γ prediction model consisted of 6 pathomic features. The AUC of the ROC was 0.757 and 0.709 in training and validation sets, respectively. The calibration curves did not deviate from the reference line. The calculated pathomic score was an independent prognostic factor for the overall survival of BC patients (HR = 0.604, 95% CI 0.392 − 0.93). Pathomic features were found to be significantly correlated with T cells CD4 memory, T cells follicular helper and Macrophages M1 infiltrate abundance, and with immune genes, such as CD28, CD27, PDCD1 and CTLA4, (p < 0.05).
Conclusions
The pathomic model could predict the expression of IFN-γ and patients’ outcomes in breast cancer. The features were significantly related to the abundance of immune cell infiltration and genes.
How mixed messages may be better than silence in climate change education
Authors: Stevenson Kathryn , Busch K. C. , Peterson M. Nils , Lawson Danielle F. , Chavez Regina Ayala 
Published: July 2023

Abstract
Polarization around climate change viewpoints – including climate change concern and commitment to action – continues to be a persistent challenge to collective action in the United States, and across the globe. Multiple studies have found that K-12 science teacher perceptions of climate change reflect that of the general population, raising concerns that education may be replicating among students the polarization found among adults. However, few have examined how approaches to teaching climate change may be linked to climate change concern and behavior among students. We began to address this gap with a pre/post survey of 354 middle school students from eight science classrooms across North Carolina and their teachers. We measured changes in climate change concern and behavior among students, student-reported frequency of discussing climate change in class, and teacher-reported approach to teaching climate change as consistent with the scientific consensus (climate change is attributed to human activity; 13.2% of students in these classes), mixed messages (climate change is attributed to both human and natural causes; 53.2% of students), denial (climate change is attributed to natural causes; none of students) and avoidance (not discussing climate change; 33.5% of students). We also controlled for socioeconomic status (Title I) and location (rural versus urban) of the school. We detected gains in both concern and behavior across all teaching approaches. We also found frequency of school-based discussion about climate change was the most predictive of gains in concern, but no measured factors predicted gains in behavior. Baseline concern and behavior levels did vary across the different treatment approaches, with lower baselines concern and levels found among teachers who take an avoidance and mixed messages approaches. Together, these results suggest that cultural contexts may be the drivers of both teaching approaches and student climate change concern and behavior, but variations in teaching approaches are not polarizing forces themselves. Instead, encouraging classroom-based conservations about climate may boost concern levels, even in cultural contexts that do not prioritize scientific consensus about climate change drivers. These findings may provide guidance for teaching climate change as well as other politically fraught topics.
Molecular characterization of head and neck infection causing bacterial communities using 16S rRNA in eastern Indian population
Authors: Lenka Smarita , Swain Subrat , Sahu Basanta , Lenka Rajesh , Sahu Kundan , Sahu Mahesh , Swain Santosh , Dubey Debasmita 
Published: July 2023

Abstract

Head and neck infections (HNI) are dangerous illnesses caused by a variety of bacterial species. Due to either incorrect diagnosis or excessive antibiotic usage, multidrug resistance (MDR) poses a problem on a global scale. We aimed this study to identify and compare their relationship with eastern Indian MDR bacteria.We collected 264 HNI clinical samples (2020–2022) from the eastern Indian state of Odisha to investigate the bacterial isolates associated with HNI, as well as the characterization was performed with their drug susceptibility and assessment of their diversity by comparison with worldwide bacterial isolates. There are 218 positive bacterial samples. Using the 16S rRNA gene, we performed molecular characterization and phylogenetic analysis on 25 multidrug-resistant bacteria. According to population genetic factors, the haplotype (Hd) and nucleotide diversity (π) ranged from 0.558 to 0.828 and 0.03236 to 0.28428.The prevalence of these neglected pathogens within this rarely focused geographical area and the transboundary potential to find better therapeutic approaches can be possible through this study.
Decorated graphene oxide with gold nanoparticles as a sensitive modified carbon paste electrode for simultaneous determination of tyrosine and uric acid
Authors: Bojdi Majid Kalate , Behbahani Mohammad , Garazhian Elahe 
Published: July 2023

Abstract
It is presented here as a simple and selective method to simultaneously determine tyrosine and uric acid using a modified carbon paste electrode decorated with graphene oxide and gold nanoparticles (GO/AuNPs/MCPE). In order to characterize and evaluate the morphology and constituents of the nanostructures, X-ray diffraction spectroscopy, Transmission electron microscopes, Dynamic light scattering, Zeta potential, electrochemical impedance spectroscopy, and Voltammetry were employed. The current response on the surface of the modified electrode had a dynamic linear range (DLR) relationship in the concentrations of 0.14-340.00 µmol L-1 and 0.06-141.00 µmol L-1 for tyrosine and uric acid, respectively, and the method detection limit (MDL) was 0.0060 µmol L-1 and 0.0037 µmol L-1, respectively. This modified electrode provided high stability, sensitivity, and acceptable reproducibility for voltammetric measurements of tyrosine and uric acid simultaneously in a biological matrix.
Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope
Authors: Jin Long , Zhong Xiaoxuan , liang yizhi , Wang Xiaoyu , Lan Haoying , Bai Xue , Guan Bai-Ou 
Published: July 2023

Abstract
We report the development of a head-mounted photoacoustic fiberscope for cerebral imaging in a freely behaving mouse. The 4.5-gram imaging probe has a 9-µm lateral resolution and 0.2-Hz frame rate over a 1.2-mm wide area. The probe can continuously monitor cerebral oxygenation and hemodynamic responses at single-vessel resolution, showing significantly different cerebrovascular responses to external stimuli under anesthesia and in the freely moving state. For example, when subjected to high-concentration CO2 respiration, enhanced oxygenation to compensate for hypercapnia can be visualized due to cerebral regulation in the freely moving state. Comparative studies exhibit significantly weakened compensation capabilities in obese rodents. This new imaging modality can be used to study normal and diseased-state cerebrovascular functions and shows promise in neuroscience and microcirculation studies.
Enhanced Performance Triboelectric Nanogenerator Based on Polydimethylsiloxane (PDMS)/ Barium Titanite (BTO) / Graphene Quantum Dot (GQD) Nanocomposites for Energy Harvesting
Authors: Hatta Faizatul Farah , Shazni Muhammad Aniq , Mohamed Mohd Ambri 
Published: July 2023

Abstract
Triboelectric nanogenerators (TENGs) have been developed as promising energy-harvesting devices to effectively convert mechanical energy into electricity. A TENGs is using either organic or inorganic materials to initiate the triboelectrification process, followed by charge separation. In this study, a high-performance composite based triboelectric nanogenerators (CTENGs) device, based on PDMS as a polymeric matrix with BTO nano-powders (NPs) as dielectric fillers and graphene as conductive media was fabricated. The PDMS/BTO/GQD composite film was prepared with the GQD doped into the mixture of PDMS/BTO and mechanically stirred. The composition of GQD varied from 0 to 40 wt%. The composite was spin coated onto flexible ITO on PET sheet and dried in the oven at 80°C for 24 hours. The output performance of TENGs is enhanced by the increased concentration of 30 wt% GQD which is two times higher than nanocomposite films without GQD. The PDMS/BTO/G30 TENGs film showed an increase open-circuit voltage output (VOC), short-circuit current output (ISC) and power density reaching ~ 310.0 V, ~ 23.0 mA and 1.6 W/m2 respectively. The simple and scalable process for the PDMS/BTO/GQD TENGs would benefit as a sustainable energy harvesting system in small electronic devices.
Behavioral fluctuation reflecting theta-rhythmic activation of sequential working memory
Authors: Ushiyama Junichi , Ideriha Takuya 
Published: July 2023

Abstract
Sequential working memory, the ability to actively maintain sequential information, is essential for our cognition and has been considered to be represented rhythmically within the theta (3–7 Hz) range. In the current study, we predicted that if the sequential information is truly activated rhythmically, there should be periodic fluctuation in our behavior where the easiness/quickness to recall the information rises and falls according to the theta rhythm. We conducted detailed analyses on reaction times (RT) for retrieving sequential and non-sequential information in six experiments (total n = 110). The results revealed that the RT for recalling the sequential information showed fluctuation in the theta range and was significantly stronger than that observed when sequential order was not necessary to remember. Taken together, we revealed that our behavior displayed theta-rhythmic fluctuation when recalling sequential information in a relatively large sample, supporting theta phase-dependent coding of sequential working memory.
Identification and validation of ferroptosis-Related genes in sarcopenia
Authors: Chen Yanzhong , Zhang Yaonan , Zhang Sihan , Ren Hong 
Published: July 2023

AbstractBackground:Ferroptosis, characterized by iron accumulation and lipid peroxidation, leads to cell death. Growing evidence suggests the involvement of ferroptosis in sarcopenia. However, the fundamental ferroptosis-related genes (FRGs) for sarcopenia diagnosis, prognosis, and therapy remain elusive. This study aimed to identify molecular biomarkers of ferroptosis in sarcopenia patients.Methods:Gene expression profiles were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between normal and sarcopenia samples were identified using the "limma" package in R software. FRGs were extracted from GeneCards and FerrDB databases. Functional enrichment analysis determined the roles of DEGs using the "clusterProfiler" package. A protein-protein network was constructed using Cytoscape software. Immune infiltration analysis and receiver operating characteristic (ROC) analysis were performed. mRNA-miRNA, mRNA-TF, and mRNA-drug interactions were predicted using ENCORI, hTFtarget, and CHIPBase databases. The network was visualized using Cytoscape.Results:We identified 46 FRGs in sarcopenia. Functional enrichment analysis revealed their involvement in critical biological processes, including responses to steroid hormones and glucocorticoids. KEGG enrichment analysis implicated pathways such as carbon metabolism, ferroptosis, and glyoxylate in sarcopenia. Totally, 11 hub genes were identified, and ROC analysis demonstrated their potential as sensitive and specific markers for sarcopenia in both datasets. Additionally, differences in immune cell infiltration were observed between normal and sarcopenia samples.Conclusion:The hub genes identified in this study are closely associated with ferroptosis in sarcopenia and can effectively differentiate sarcopenia from controls. CDKN1A, CS, DLD, FOXO1, HSPB1, LDHA, MDH2, and YWHAZ show high sensitivity and specificity for sarcopenia diagnosis.
Analyzing Concentration in the Greek Public Procurement Market: A Network Theory Approach
Authors: Pliatsidis Andreas Christos 
Published: July 2023

Abstract
This study uses network theory to analyze the structure and concentration of the Greek public procurement market, focusing on the relationships between Contracting Authorities (CAs) and Economic Operators (EOs) within different Common Procurement Vocabulary (CPV) groups. By examining degree distribution curves and identifying dominant economic operators, we gain valuable insights into market dynamics and competition in Greece. The findings reveal the presence of market concentration, where a few EOs receive a disproportionate share of contracts within certain CPV groups which suggests potential market dominance and lack of competition. In contrast, some CPV groups demonstrate a more balanced distribution of contracts among EOs, suggesting a healthier competitive environment. The analysis of degree distributions between sub-networks based on CPV groups indicates variations in market structures between sectors. These differences highlight the heterogeneity in the Greek public procurement market, as well as the need for sector-specific policy interventions. Given that the concentration of contract awards raises competition, fairness and transparency concerns, the implications of the findings are important for policymakers, regulators and stakeholders involved in the Greek public procurement market. While this study provides valuable information, limitations including variations in data availability and potential inaccuracies in recorded information exist. Future research should address these limitations and explore the effects of market concentration on CPV codes in greater depth. This study contributes to the public procurement literature and serves as a basis for further research and policy making in the Greek procurement sector.