bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of clinicopathological features on prognosis in malignant ovarian germ cell tumors
Authors: SEYİDOVA Yegana , SEYFETTİNOĞLU Sevtap , KÜÇÜKGÖZ GÜLEÇ Ümran , KHATİB Ghanim , GÜZEL Ahmet Barış , GÜMÜRDÜLÜ Derya , PAYDAŞ Semra , VARDAR Mehmet Ali 
Published: March 2023

Purpose: Malignant ovarian germ cell tumors cause 5% of ovarian cancers. Studies examining prognosis and survival rates are significant due to malignant ovarian germ cell tumors' rarity. We aimed to investigate outcome and prognostic factors in these patients.
Materials and Methods: The study includes clinicopathological records of malignant ovarian germ cell tumor patients in our clinic between April 1992 and November 2017. Demographic and clinical characteristics, pathological observations, adjuvant treatment modalities, and follow-up details were analyzed, and their survival effects were investigated.
Results: One hundred fifteen patients with malignant ovarian germ cell tumors were analyzed. Most patients were reproductive-age nulliparous. The patients' mean age was 27.5+14.3, and the mean follow-up was 71.04 months. The research includes 42 dysgerminomas, 37 immature teratomas, 17 mixed germ-cell tumors, 16 endodermal sinus tumors, and three embryonic carcinomas. The disease stage was 1, 2, 3, and 4 in 53%, 16.5%, 25.2%, and 5.2% of patients, respectively.
Fertility-sparing surgery was conducted in 55 of 79 patients, and 34.5% received pregnancy. Five-year overall survival was 74%. Localization of tumors, non-optimal cytoreduction, advanced-stage disease, poor differentiation, metastasis, and mixed cell histology were determined as poor prognostic factors. In multivariate analyzes, factors affecting disease-free survival are the FIGO stage, mixed germ cell histology, and suboptimal cytoreduction.
Conclusion: The prognosis of malignant ovarian germ cell tumors is excellent, especially in young, early-stage, and adequately operated patients. FIGO Stage, mixed germ cell histopathology and complete cytoreduction affect the prognosis of MOGCT. Treatment at reproductive age does not significantly affect pregnancy outcomes. Therefore, the fertility sparring approach should be considered a good option, especially in young patients.
The effect of astaxanthin on amiodarone induced cardiac tissue damage in rat
Authors: KARA Özlem , KİLİTCİ Asuman 
Published: March 2023

Purpose: The aim of this study was to evaluate the effect of astaxanthin on amiodarone induced cardiac tissue damage.
Materials and Methods: 3 groups were formed using 30 Wistar albino rats. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. In group 2 (amiodarone group) (n=10), 100 mg/kg amiodarone was given for 7 days. In group 3 (amiodarone+astaxanthin group) (n=10), 100 mg/kg amiodarone and 25 mg/kg astaxanthin were given for 7 days. Hearts were surgically extirpated in all groups. Blood malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as edema, hemorrhage, fibrosis, inflammatory cell infiltration were assessed by examining the slides prepared from cardiac tissue with microscopy.
Results: The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than group 3. Tissue damage was significantly higher in group 2 than group 3.
Conclusion: According to our short term findings, astaxanthin reversed the toxicity of amiodarone on cardiac tissue. In the light of these promising results, we suggest that astaxanthin usage should be thought to protect the cardiac damage due to amiodarone.
The adherence of parents regarding epinephrine auto-injector use in anaphylaxis management: a real-life study
Authors: SERBES Mahir , ŞAŞİHÜSEYİNOĞLU Ayşe Şenay , ÖZCAN Dilek , KİSLA EKİNCİ Rabia Miray , BALCI Sibel , ALTİNTAS Derya 
Published: March 2023

Purpose: The purpose of this study was to identify unmet needs in the management of anaphylaxis by assessing the practical skills of the parent(s) regarding the use of epinephrine auto-injectors (EAIs) and determining the factors influencing them.
Materials and Methods: The study included 114 primary caregivers of children prescribed an EAI with an anaphylaxis risk. A structured mini-interview with a practice test using a trainer device was performed.
Results: Epinephrine was described as a life-saving and first-line treatment for anaphylaxis by 93 parents (81.6%). However, only 53 parents (46.5%) stated that they carry an EIA device with them regularly in their daily lives. 38 children (33.3%) had relapsing episodes, but among those experiencing anaphylaxis, only 6 parents (20%) used EAI despite carrying. According to respondents, the main factor avoiding AEI's regular carriage was a lack of belief in necessity (18, 29.5%). Among participants, only 13 (11.4%) of the parents were able to administer EAI correctly in all 5 steps. An inverse relationship between the ability to use the device and the time elapsed since the last visit s was found.
Conclusion: Low adherence levels among parents highlighted the urgent need to improve this situation. Interventions including regular EAI training and psychological support should be provided among parents, but may not guarantee to maintain acquired adherence to EAIs in real life.
Alcances del principio de causalidad en el impuesto a la renta empresarial
Authors: Durán Rojo Luis 
Published: March 2023

El artículo analiza los alcances de la aplicación del principio de causalidad para la determinación de la renta neta imponible a efectos de aplicar el impuesto a la renta empresarial.Se parte de establecer que dicho principio es aplicable a erogaciones que sean consideradas como gasto deducible del ejercicio, mas no de aquellas que han de formar parte del costo computable de los bienes a enajenar. Luego, se realiza un extenso análisis de la manera como la ley del impuesto a la renta peruana ha configurado los alcances de este principio y el entendimiento que ha surgido en la casuística jurisprudencial de los órganos que resuelven conflictos, especialmente del Tribunal Fiscal, al acoger en la esfera del principio precitado gastos no causales.A su vez, el artículo aborda los alcances de los principios de razonabilidad y normalidad del gasto, tan necesarios para la evaluación del cumplimiento del principio de causalidad.Finalmente, se plasman unas reflexiones respecto a la acreditación de la fehaciencia del gasto y su vinculación con el principio de causalidad.
(Ir) Relevância das contingências ambientais: uma investigação nas empresas brasileiras
Authors: Minatti Ferreira Denize Demarche , Borba José Alonso , Aguiar Da Rosa Carolina , Rodrigues Vicente Ernesto Fernando 
Published: March 2023

As empresas enfrentam novos desafios no que diz respeito ao cumprimento de normas éticas, trabalhistas e ambientais. Para que se tenha reputação no aspecto social e ambiental é fundamental que se transmita transparência e confiabilidade nas ações. Deste modo, as empresas devem disponibilizar as informações exigidas por lei, mas que não se restrinjam ao que determina a norma; informações adicionais podem ser divulgadas objetivando transparência das demonstrações contábeis. Nesse sentido, o presente artigo teve por objetivo identificar a significância financeira dos valores das con- tingências passivas e provisões ambientais evidenciadas em 295 empresas que negociam suas ações na Bolsa de Valores, Mercadorias e Futuros - BM&FBovespa S.A. e que são consideradas potencialmente poluentes de acordo com legislação brasileira que dispõe sobre a Política Nacional do Meio Ambiente. Para identificar o quanto os passivos contingentes representam financeiramente para as empresas investigadas foi calculado o fator de significância a partir da divisão entre as contingências ambientais e provisões com o lucro líquido. Quanto ao impacto que as contingências causariam se todas tivessem sua probabilidade de ocorrência como provável e devessem ser provisionadas, observa-se que 25% das empresas teriam seus lucros reduzidos em mais da metade e até mesmo obteriam prejuízos. Por outro lado, cerca de metade das empresas possui uma significância de até 7% em relação ao lucro líquido, inferindose que a relevância das contingências passivas ambientais para maior parte das empresas é baixa se relacionadas ao lucro líquido das mesmas.
Efectos del cambio climático en la economía, el comercio internacional y la estrategia empresarial
Authors: Duarte Cueva Franklin 
Published: March 2023

El impacto del cambio climático produce variaciones en la producción de bienes y servicios, modifica los patrones de consumo de los compradores, afecta las estrategias de los empresarios privados e influye en las políticas ambientales de los gobiernos. En este contexto, la rentabilidad esperada por los accionistas o socios puede no lograrse debido a factores incontrolables, que muchas veces generan amenazas u oportunidades para las empresas, según la industria en la que operen. Por otro lado, el comercio internacional es afectado por el cambio climático al aumentar las exigencias sanita- rias de parte de los gobiernos, las asociaciones de negocios retail y los consumidores. Esta situación conduce a redefinir estrategias de negocios y a la implementación de normas, por parte de organismos internacionales relacionados directa o indirectamente al cambio climático, en la búsqueda de adaptar o mitigar sus efectos sobre la vida en el planeta.
The Presence of the Defense Lawyer in Vietnam’s Criminal Justice System: Substantive or Cosmetic?
Authors: Chi Le Lan , Lan Nguyen Thi , Ngan Nguyen Hoang 
Published: March 2023

Defense lawyers play an important role in protecting the rights and interests of the accused, contributing to upholding justice and reducing the number of wrongful convictions. In Vietnam, in accordance with the current Criminal Procedure Code of 2015, defense lawyers have been given more and more rights to perform legal defense activities. However, defense lawyers are still considered to bepassive participants in criminal proceedings, classified under the “judicial complementary” group. The right of lawyers to collect evidence is restricted. Furthermore, other rights have not been fully implemented. The number of lawyers compared to the entire population remains low, and there are very few criminal cases that include the participation of defense lawyers. These circumstances beg the question of whether the presence of defense lawyers in Vietnam’s criminal justice system is substantive or merely a cosmetic façade intended to improve Vietnam’s global image. This paper seeks to answer this question by analyzing the results of surveys conducted with Vietnamese lawyers. Moreover, it provides some recommendations to strengthen the role of defense lawyers in the criminal justice system of Vietnam.
In the Question of Geospatial Information Data Use in the Forestry Legislation Making in Indonesia
Authors: Wijoyo Suparto , Prihatiningtyas Wilda , Wahyuni Indria , Putri Dita Elvia Kusuma , Noventry Ardhana Christian 
Published: March 2023

The high rate of deforestation and many forest disputes in Indonesia show that forest management in Indonesia is not based on the principles of good forest governance. It also shows that there is still a lack of attention to the aspect of sustainable forest development which focuses on a balanced sustainability condition between the three forest functions (production, ecology, and socio-economic functions). Geospatial Information is expected to be the solution to help provide an accurate data and information which mapping forest development in accordance with the conditions of each forest area, so that the three functions can operate coherently. Furthermore, with the presence of integrated geospatial data, it can be used as a tool in policy formulation, decision making, and/or dispute resolution in the forestry sector. This paper applies empirical juridical research consisting participatory methods through discussions and interviews with related parties. In practice, the legal materials are firstly collected by using inventory and documentation. Then, it’s completed by interviews and Focus Group Discussion data. Moreover, it also applies statutory, conceptual, and case approaches. This paper highlights the use of geospatial information data in the forestry legislation making in Indonesia. Hence, this paper will present new information about the model of forestry dispute resolution based on geospatial information.
MATHEMATICAL ASPECTS OF DETERMINING THE MOTION PARAMETERS OF A TARGET BY UAV
Authors: Hashimov Elshan , Sabziev Elkhan , Huseynov Bahruz , Huseynov Mugabil 
Published: March 2023

Research relevance When performing reconnaissance missions, a UAV system primarily conducts surveillance of the target area, locates stationary or moving enemy targets, determines their coordinates or transmits their images directly to the command post. Directing artillery fire as well as guiding missiles or carrying out target designation (illumination of targets) for high-precision weapons, automatic determination of target coordinates and their prompt transmission to the appropriate ground stations is essential. This article provides a mathematical solution to the issue of determining the motion parameters of a target spotted during surveillance of an area by a reconnaissance drone (UAV). The subject of the study in the article is UAV- rocket-artillery systems. The purpose of the work is to develop a mathematical model for determining the parameters of the target's movement using a UAV. The following tasks are solved in the article: to develop target positioning diagram; to develop a mathematical model for determining the parameters of the target's movement. The methods used in the article are the methods of mathematical modelling. The following results were obtained: а target positioning scheme has been compiled to determine the coordinates and movement parameters; a mathematical dependence has been developed to determine the coordinates of a fixed target; a mathematical model has been developed to determine the parameters of the target's movement. Conclusions: by calculating the current coordinates of a moving target using the method proposed in this paper, it is possible to determine the coordinates of the target and parameters of the target's movement, including the direction of movement and the trajectory.
Vehicle Detection in Low Illumination Based on Attention Mechanism and RetinexNet
Authors: Qu Rongdan , Li Xingke 
Published: March 2023

Abstract
This study proposes a method to detect vehicles by enhancing the YOLOv5 network 1
structure and incorporating RetinexNet to address the problem of limited detection capabilities of 2
target identification algorithms in low illumination conditions, such as at night time. CBAM attention 3
module is implemented in the network’s Neck detection layer to extract the vehicle’s primary features, 4
reduce the extraction of unused features, and improve the vehicle’s detection performance. The 5
DIoU is introduced as the loss function of the model to solve the imprecise location of the prediction 6
box and speed up the convergence of the model. RetinexNet is applied to enhance the detection 7
capabilities of low-illumination images by enhancing and denoising them. The experimental results 8
indicate that the enhanced model detects vehicles with 90% accuracy in low-light conditions and has 9
a strong detection performance overall.
Suspected undiagnosed ADRD among Middle Eastern and North African Americans
Authors: Kindratt Tiffany Billmeier , Ajrouch Kristine J , Zahodne Laura B , Dallo Florence J. 
Published: March 2023

Abstract
Background
ADRD underdiagnosis among minority populations is well-established and known to be more prevalent among women. Yet, it remains unclear if these patterns exist among Middle Eastern and North African (MENA) adults. We estimated ADRD underdiagnosis among MENA and other US- and foreign-born non-Hispanic Whites and compared sex-stratified results.
Methods
We linked 2000–2017 National Health Interview Survey and 2001–2018 Medical Expenditure Panel Survey data (ages > = 65 years, n = 23,981). Undiagnosed ADRD was suspected if participants reported cognitive limitations without corresponding ADRD diagnosis.
Results
Undiagnosed ADRD was highest among MENA adults (15.8%) compared to non-Hispanic Whites (US-born = 8.1%; foreign-born = 11.8%). MENA women had 2.52 times greater odds (95% CI = 1.31–4.84) of undiagnosed ADRD compared to US-born White women after adjusting for risk factors.
Discussion
This study contributes the first national estimates of undiagnosed ADRD among MENA adults. Continued research is needed to facilitate policy changes that more comprehensively address health disparities and related resource allocation.
Spontaneous Formation of MXene-Oxidized Sono/Chemo-Dynamic Sonosensitizer/Nanocatalyst for Antibacteria and Bone-Tissue Regeneration
Authors: Yu Yang , Sun Houyi , Lu Qunshan , Sun Junyuan , Zhang Pengfei , Zeng Linran , Vasilev Krasimir , Zhao Yunpeng , Chen Yu , Liu Peilai 
Published: March 2023

Abstract
Prolonged and incurable bacterial infections in soft tissue and bone are currently causing large challenges in the clinic. Two-dimensional (2D) materials have been designed to address these issues, but materials with satisfying therapeutic effects are still needed. Herein, CaO2-loaded 2D titanium carbide nanosheets (CaO2-TiOx@Ti3C2, C-T@Ti3C2) were developed. Surprisingly, this nanosheet exhibited sonodynamic ability, in which CaO2 caused the in situ oxidation of Ti3C2 MXene to produce acoustic sensitiser TiO2 on its surface. In addition, this nanosheet displayed chemodynamic features, which promoted a Fenton reaction triggered by self-supplied H2O2. We detected that C-T@Ti3C2 nanosheets increased reactive oxygen species (ROS) production in response to sonodynamic therapy, which displayed an ideal antibacterial effect. Furthermore, these nanoreactors facilitated the deposition of Ca2+, which promoted osteogenic transformation and enhanced bone quality in osteomyelitis models. Herein, a wound healing model and prosthetic joint infection (PJI) model were established, and the C-T@Ti3C2 nanosheets played a protective role in these models. Taken together, the results indicated that the C-T@Ti3C2 nanosheets function as a multifunctional instrument with sonodynamic features, which might reveal information regarding the treatment of bacterial infections during wound healing.
Long noncoding RNA MALAT1 promotes angiogenesis through the caveolin-1/VEGF pathway after cerebral ischemic injury.
Authors: Lin Yao , Pang Qiongyi , Shi Yuanxi , Hu Xuanbo , Zhu Anqi , Ge Changjun , Wu Kecheng , Chen Xiang , Tu Fengxia 
Published: March 2023

Abstract
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), has been reported to potentially protect against cerebral ischemic injury. We investigated the role and underlying mechanism of MALAT1 in ischemic stroke. A mouse model of middle cerebral artery occlusion/reperfusion (MCAO/R) and a human brain microvascular endothelial cell (HBMEC) model of oxygen-glucose deprivation/reoxygenation (OGD/R) were established. The Zea Longa 5-point scale, VEGFR2/CD34 double immunofluorescence (IF), TUNEL staining, cell counting kit-8 (CCK-8) assay, tube formation assay, Transwell assay, and qRT–PCR were used to evaluate neurological deficits, endothelial cell (EC) proliferation, cell apoptosis, cell viability, in vitro angiogenesis, cell migration, and MALAT1 levels in mice, respectively. MALAT1 was found to promote cell migration and tube formation in vitro by affecting the caveolin-1/VEGF pathway. Downregulation of MALAT1 expression in vivo exacerbated cerebral ischemic injury as manifested by severe neurological deficits, elevation of apoptosis, and a decrease in the number of VEGFR2+/CD34+ endothelial progenitor cells (EPCs). These findings indicated that MALAT1 may promote angiogenesis after cerebral ischemic injury via the caveolin-1/VEGF pathway, thereby suggesting that MALAT1 is a therapeutic target for ischemic stroke.
Lap-shear performance of weld-bonded Mg alloy and austenitic stainless steel in three-sheet stack-up
Authors: Manladan S.M. , Hamza Mukhtar , Ramesh S. , Luo Z. 
Published: March 2023

Abstract

To overcome the challenges encountered in conventional resistance spot welding (RSW) of three-sheet stack-up involving Mg alloy and austentic stainless steel (ASS), the feasibility of using weld-bonding was investigated. The microstructure and mechanical properties of the joints (Mg alloy/ASS/ASS) were investigated. The Mg alloy and upper ASS were joined together by the combined effect of the cured adhesive and welding-brazing in the weld zone, while a metallurgical bond was formed at the ASS/ASS interface. The Mg nugget microstructure exhibited fine columar grains consisting of largely primary α-Mg grains and eutectic mixture of α-Mg and β-Mg17Al12. The nugget formed at the ASS/ASS interface consisted largely of columnar grains of austenite, with some equiaxed dendritic grains formed at the centerline of the joint. The weld-bonded joints exhibited an average peak load and energy absorption of about 8.5 kN and 17 J, respectively (the conventional RSW joints failed with little or no load application). As the welding current changed, two types of failure modes were observed: Interfacial failure via the Mg nugget/upper ASS interface and partial interfacial failure (part of the Mg nugget was pulled out of the Mg sheet). Both failure modes were accompanied by cohesive failure in the adhesive zone.
Research on Reliability of Sports Intelligent Training System Based on Hybrid Wolf Pack Algorithm and IoT
Authors: Chen Wenfeng , Huang Xinyan 
Published: March 2023

Abstract
To expand the application scope of the WCA algorithm in the actual process, this research has optimized the problems in the algorithm in two aspects: The first aspect further improves the operating mechanism of the WCA algorithm and improves the performance of optimization problem. In the second aspect, other optimization strategy mechanisms of the WCA algorithm are introduced to enable the algorithm to optimize multi-objective and multi-dimensional problems. This paper studies a physical test system and sports intelligent based on hybrid wolf pack algorithm and IoT. The system collects and sends data from the data collection terminal of the Web server, receives the data through the wireless module, and sends it to the Web server through the network. The web server processes and stores the data information to generate a database, and users can view their own sports information by logging in to the web service program with the account password. In addition, the teacher and administrator accounts have the ability to view all users' exercise information. The system adds three sports items, pull-ups, squats, and standing long jumps. At the same time, the system uses a general motion recognition algorithm, which can effectively reuse and add new sports items. According to the actual needs of intelligent sports training, this paper combines somatosensory technology, bone tracking technology and motion recognition algorithm to realize a high-precision, low-latency intelligent sports training system.