bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative assessment of pomegranate extract, sodium hypochlorite, chlorhexidine, Myrrh (Commiphora molmol), tulsi extract against Enterococcus faecalis, Fusobacterium nucleatum and Staphylococci epidermidis
Authors: Sisodiya Mallwika , Ahmed Shadab , Sengupta Ranjan , Priyanka  , Saha Ankit Kumar , Verma Gourav 
Published: April 2023

Background:
The presence of pathogenic bacteria, toxins and byproducts in the root canal system show a decisive part in success of endodontic therapy. Thus, the complete removal of this bacterium is highly desirable. Several intracanal medicaments were tried to disinfect the root canal before obturation.

Aim:
The present study was conducted to compare Pomegranate, sodium hypochlorite, Chlorhexidine, Myrrh (Commiphora molmol), tulsi extract against Enterococcus faecalis, Fusobacterium nucleatum and Staphylococci epidermidis.

Settings and Design:
Cross-sectional observational prospective study.

Materials and Methodology:
Aqueous extract of 20% pomegranate peel, 20% pomegranate peel, 0.2% CHX, 2.5% sodium hypochlorite, Tulsi extract and Myrrh (Commiphora molmol) was used as agent against E. faecalis, F. nucleatum and Staphylococci Epidermidis. Zone of inhibition and minimum inhibitory concentration (MIC) was calculated and compared using analysis of variance and Mann–Whitney test. The information was statistically evaluated with SPSS software version 20 with P < 0.05.

Results and conclusion:
The mean zone of inhibition against E. faecalis, F. nucleatum and S. Epidermidis was highest in chlorhexidine and sodium hypochlorite groups compared to herbal groups. MIC was least with group III followed by group II against all bacterial species (P < 0.05). Sodium hypochlorite found comparatively better followed by chlorhexidine and other agents against E. faecalis, F nucleatum and S. epidermidis.
Investigating the access barriers to oral and dental health services for children from the perspective of parents attending the health centers of Kerman
Authors: Vali Leyla , Zare Zahra , Jahani Yones , Kalavani Khalil 
Published: April 2023

Background:
Oral health plays a key role in people's overall health. Dental caries is the most important problem in children's oral health. Despite significant advances made in the area of oral health around the world, there is inequality in access to oral health within Iran and abroad, and this is considered a public health challenge. This study was conducted to investigate the access barriers to children's oral health services from the perspective of parents attending the health centers of Kerman, Iran.

Materials and Methods:
The present descriptive-analytical study was carried out, as a cross-sectional survey, on 410 parents of children living in Kerman, Iran. The data were collected by access barriers questionnaire, and then were analyzed by SPSS software using descriptive statistical methods and the multiple linear regression test. Confidence interval (CI) in this study was 95% (95% CI).

Results:
The most common access barrier to children's oral health was the high treatment cost. The access barriers to children's oral health services were significantly associated with parental education (P = 0.00), maternal employment (P = 0.04), supplementary insurance (P = 0.00), and family income (P = 0.01). Parental satisfaction was also significantly correlated to the child's sex (P = 0.04), supplementary insurance (P = 0.04), and number of filled teeth (P = 0.04). The mean score of parental satisfaction was 1.83 ± 0.34; within the range of 1–3 from satisfied to dissatisfied.

Conclusion:
The cost of dental treatment services high and there are many barriers to accessing children's oral health.
Investigation of the antifungal effects of curcumin against nystatin-resistant Candida albicans
Authors: Hajifathali Soha , Lesan Simin , Lotfali Ensieh , Salimi-Sabour Ebrahim , Khatibi Mandana 
Published: April 2023

Background:
Emergence of nystatin-resistant Candida albicans (C. albicans) strains has raised some concerns in the recent years. Recent scientific evidence proves that turmeric, especially curcumin, has anti-inflammatory and anti-fungal activity. The aim of this study was the investigation of the antifungal effects of curcumin against nystatin-resistant C. albicans.

Materials and Methods:
This in vitro, experimental study evaluated standard-strain (ATCC 16201) and 10 nystatin-resistant C. albicans strains. The antifungal activity and minimum inhibitory concentration (MIC) of curcumin were evaluated using the CLSI-M27-A3, and the MIC of curcumin was compared with that of nystatin. The results were analyzed using the one-way ANOVA.

Results:
The MIC of curcumin was 15.6, 32.25, 15.6, 7.8, 32.25, 15.6, 15.6, 15.6, 32.25, and 15.6 μg/mL for the 10 resistant strains and 62.5 μg/mL for the standard strain of C. albicans. Curcumin in the above-mentioned concentrations significantly inhibited the proliferation of nystatin-resistant C. albicans strains (P < 0.001).

Conclusion:
According to this research, it was shown that curcumin with MIC value of 7.8–32.25 μg/mL has inhibitory effects on nystatin-resistant C. albicans strains.
Human papillomavirus in oral squamous cell carcinoma using p16 and its co-relationship with cervical lymph node metastasis and clinicopathological parameters
Authors: Khalesi Saeedeh , Eskandari Shahnaz , Jahanshahi Gholamreza , Nasr Faezeh 
Published: April 2023

Background:
Due to the increasing prevalence of oral squamous cell carcinoma (OSCC) in Iran and especially in young people, this study aimed to identify human papillomavirus (HPV) using p16 in OSCC.

Materials and Methods:
In this descriptive-analytical cross-sectional study, 40 samples from the archives of the Pathology Department of Kashani Hospital were selected by a definitive diagnosis of OSCC with neck dissection. Demographic information including age, gender, location, and size of the lesion was obtained. Samples were divided into two groups based on lymph node (LN) metastasis. Immunohistochemical staining was performed for p16. Data were entered into SPSS 24 software and statistically analyzed by t-test, ANOVA, and Spearman nonparametric test. P <0.05 was statistically significant.

Results:
The mean age of patients was 59.7 ± 17.11 which in terms of age and gender there was no significant difference between the two groups including with and without cervical LN metastasis (P > 0.05). There was no significant difference between the two groups based on the grade of tumor, perninural invasion, tumor size and location (P > 0.05). The only significant difference between the two groups was based on lymphovascular invasion and disease stage (P < 0.05). The p16 expression also showed a significant difference between the two groups (P < 0.05).

Conclusion:
In OSCCs without cervical LN metastasis, a significant increase in p16 expression was observed compared to samples with cervical LNs metastasis. The presence of HPV was higher in samples with less LNs metastasis and possibly a better prognosis.
General awareness of symptoms of myocardial infarction and the need for urgent treatment
Authors: E Thirumurugan , K Gomathi , P Swathy , Afrin Syed Ali , Alekhya Ponduri Lakshmi , B Jishnu , Das Banashree 
Published: April 2023

Objective:
To investigate the golden-time-awareness of and the necessary actions in response to acute myocardial infarction among the general public.

Methods:
This study was conducted with the use of a descriptive research design and convenience sampling. A sample of 800 subjects, using self-structured knowledge questionnaires, was selected for data collection and analysis. The study was conducted at Dr. M.G.R. Educational and Research Institute, India, from February to November 2022. Awareness of myocardial infarction symptoms and intervention timeline (the golden time) was investigated. A multivariate logistic regression analysis was performed to identify the demographic factors affecting the recognition of the golden time of acute myocardial infarction.

Results:
A total of 800 subjects were included. Among the subjects, 367 (45.8%) were male, 433 (54.2%) were female, and 443 (55.3%) participants failed to recognize the golden time. Our multivariate logistic regression analysis showed that people with a bachelor’s degree (OR=0.41, 95% CI: 0.23-0.74, P=0.03) and a high school level diploma (OR=0.55, 95% CI: 0.31-0.97, P=0.03) are more likely to know about myocardial infarction (golden time) than illiterate people. Additionally, people who are employed (OR=0.59, 95% CI: 0.41-0.85, P=0.05) are more likely to know about myocardial infarction (golden time) than those who are not.

Conclusions:
The majority of people in the awareness group realize that taking myocardial infarction patients to the hospital would be the best course of action. The unawareness of the ideal treatment window for myocardial infarction may cause a delay in seeking medical attention, which can lead to an increase in mortality and morbidity.
Gestational glucose intolerance (GGI) and gestational diabetes mellitus (GDM) among antenatal women attending urban community health centers of Lucknow: A cross-sectional study
Authors: Gautam Pradeep K. , Agarwal Monika , Agarwal Anjoo , Singh V. K. , Jauhari Sugandha 
Published: April 2023

ABSTRACT

Background:
Gestational diabetes mellitus (GDM) is an emerging public health concern in India, which has detrimental effects on both the mother and the baby. The data on prevalence of GDM was unavailable at secondary urban health facilities, from where a majority of pregnant women seek antenatal services, and the following study identifies this burden.

Methods:
A cross-sectional study was conducted from May 2019 to June 2020 among pregnant women attending the antenatal outpatient department (OPD) at secondary level health facilities in urban Lucknow. A semi-structured interview schedule was administered to the study subjects for collecting the relevant information and 75 g of oral glucose tolerance test was performed irrespective of the meal. The cut-off points taken for the diagnosis of GDM and gestational glucose intolerance (GGI) was as per the guidelines of the Ministry of Health and Family Welfare for diagnosis of GGI/GDM.

Results:
The overall prevalence of GDM and GGI in the study was 11.6% and 16.8%, respectively. Three-fourth of the women (22/29) were diagnosed with GDM in the second trimester of pregnancy. The prevalence of GDM (16.7%) was significantly higher in pregnant women aged more than 25 years and in those who were overweight. Mean birth weight (3.2 ± 8.1 kg) of the babies was significantly higher in the women with GDM. Among the fetal complications was respiratory distress observed among 28 pregnant women and 31% of them had GDM and this was statistically significant.

Conclusion:
The prevalence of GGI and GDM was found 16.8% and 11.6%, respectively. Gestational age, pre-pregnancy weight, pre-pregnancy BMI, weight gain during the pregnancy, family history of diabetes. PCOS, macrosomia and GDM in prior pregnancies was found to significant with GDM in the study.
Seizure in geriatric population – An unheeded integer
Authors: Narayanan Namitha , Selvaraj Shivamalarvizhi , Mohamedkalifa Abdulmuthalif , Gaur Archana , Kaliappan Ariyanachi , Reddy Kotha Sugunakar , Geetha Jeganathan , Sakthivadivel Varatharajan 
Published: April 2023

ABSTRACT

Background:
Epilepsy is one of the most prevalent neurological conditions among the elderly. Age-related epileptogenic disorders as well as the ageing itself pose a risk for seizures in the elderly. The lack of witnesses, non-specific symptoms, and transient symptoms make the diagnosis challenging in the elderly.

Aim:
This study aimed to assess the various presentation and aetiology for the seizure disorder in the elderly population.

Materials and Methods:
A total of 125 elderly patients ≥60 years with new onset seizure were included in the study. Demographic data, co-morbidities, and clinical presentation of seizure were elicited. Hemogram, liver and renal function tests, random blood sugar, electrolytes, and serum calcium were analysed. Computed tomography (CT), magnetic resonance imaging (MRI) brain, and electroencephalogram (EEG) were performed.

Results:
Seizure was seen predominantly in the males with age group of 60–70 years. Generalized tonic-clonic seizure was the commonest presentation, followed by focal seizures. The leading causes of seizures were cerebral vascular accidents, metabolic conditions, and alcohol. CT brain was abnormal in 49%, and 73% of the patients showed abnormality in MRI brain. EEG was abnormal in 17.3% of patients. Temporal lobe infarction was the commonest, trailed by parieto-temporal and frontal lobe involvement.

Conclusion:
Seizures in the elderly have varied clinical signs and aetiology. An awareness about these atypical presentation and aetiology is essential for the early diagnosis and management to prevent morbidity.
Unintentional domestic injuries among elderly in rural areas of Mandya: A community-based cross-sectional study in Southern Karnataka
Authors: Shashikantha S K , Huchchannavar Raghavendra , Jindal Har Ashish 
Published: April 2023

ABSTRACT

Background:
As the proportion of elderly in the population increases, they also become vulnerable to various types of intentional or unintentional injuries. Domestic accidents including falls among the elderly have been identified as a leading cause of injury-related morbidity and mortality in India and elsewhere.

Aim:
This study aims to assess the burden and pattern of domestic accidents in a rural part of Southern India.

Methods and Setting:
A community-based cross-sectional study among the elderly (≥60 years) was carried out in rural areas of Southern Karnataka. A semi-structured interview schedule was used to get the information on domestic accidents. Inferential statistical tests like the Chi-square test and logistic regression analysis were used.

Results:
A total of 500 persons aged ≥60 years with a mean age of 69.09 ± 7.42 years (Range 60–92 years) were included. One-third of the subjects have had an incidence of domestic accidents in the past 1 year contributing to a 35% prevalence of domestic accidents. A higher prevalence of domestic accidents was seen in those subjects who were ill (47.9%). Overall prevalence of falls was 21.4% (P = 0.007). One-fifth of the subjects with domestic accidents had a residual illness.

Conclusion and Contribution:
One-third of our subjects gave a history of one or the other form of domestic accidents in the previous 1 year. Our study highlights the problem of unintentional domestic injuries among the most vulnerable group of the elderly and calls for a continuous assessment of the burden and nature of injuries.
Study on acute respiratory infection in children aged 1 year to 5 years-A hospital-based cross-sectional study
Authors: Vinod Anuna , Kaimal Resmi S. 
Published: April 2023

ABSTRACT

Background:
Acute respiratory infections (ARIs) are the single greatest cause of death among children throughout the world. They are responsible every year for the deaths of 4.3 million children under 5 years of age worldwide. Community- or hospital-based surveys for finding out the prevalence and various factors associated with ARI are very few, especially in urban areas. Also, surveys to study the use of vaccines in preventing ARIs are scarce. Hence, we studied ARI in children aged 1 year to 5 years in a tertiary care hospital in Kerala. The aim was to determine the frequency of ARIs in the last 1 year in children aged 1 year to 5 years, attending the immunization clinic at Lourdes Hospital, Kochi, and assess the selected epidemiological, socio-demographic, nutritional and immunization factors associated with ARIs in the study group.

Methods:
Children attending the immunization clinic at a tertiary care hospital, Kochi, in the age group of 1 year to 5 years were selected. A brief introduction was given to the mother/caregiver of the child regarding the purpose of the study and was asked to fill out the questionnaire. Informed consent was taken. For the study, ARI is defined as the presence of one or more of the following: cough, running nose, blocked nose, sore throat, difficulty breathing, or ear problems; with or without fever. Results were analyzed.

Results:
Mother was the caregiver in 67% of the cases. When the caregiver was the mother, ARI is found to be less. Among those mothers who had no formal education, 100% of their children got ARI. Children whose caregivers were 30 years and older had lesser ARI. The proportion of children with ARIs was more with a history of respiratory infection among family members (parents/siblings) compared to those with no such history. The occurrence of ARI was more frequent in rural compared to urban areas. There is a significant proportion of ARI in non-exclusively breastfed infants, bottle feeding, and early initiation of complementary feeding. Children with a history of exposure to cigarette smoke had an increased occurrence of ARI. Similar results followed for exposure to biomass fuel and exposure to cold and rain. Children who were not immunized to vaccines-pneumococcal, Hib, measles, vitamin A, showed a higher occurrence of ARI compared to immunization.

Conclusion:
The studies regarding factors influencing ARI are relatively rare in an urban setting, thus this calls for more studies in urban areas. Health education can change the healthcare-seeking behavior and attitude of parents for preventing ARI-related deaths. Family physicians can play a significant role by educating caregivers of children and giving timely services. Promoting and ensuring exclusive breastfeeding practices, timely weaning after 6 months, and avoidance of bottle feeds can dramatically decrease the episodes of ARI.
Epidemio-toxicological profile of fatal poisoning cases autopsied at a tertiary care centre of North India
Authors: Kumar Rajesh , Sheikh Nishat Ahmed , Bashar Mohammad Abu , Vasudeva Abhimanyu , Kumar Adarsh , Yadav Abhishek , Gupta Sudhir K. 
Published: April 2023

ABSTRACT

Background:
Poisoning is an important health hazard and one of the leading causes of morbidity and mortality worldwide including in India. The study was conducted to understand the magnitude, pattern, and gender differentials of all poisoning fatalities in relation to the manner of death autopsied at a tertiary care center.

Methods:
A retrospective study of all fatal poisoning cases autopsied at the department of Forensic Medicine & Toxicology of a tertiary care institute in Northern India for the period 1st January 1998 to 31st December 2017 was conducted, and a profile of the victims of fatal poisoning was prepared. Data were analyzed with descriptive and inferential statistics.

Results:
The study included a total of 1099 cases of fatal poisoning autopsied at the department of Forensic medicine & Toxicology. Suicidal poisoning was reported in 90.2% of cases and accidental poisoning was seen in 8.9% of cases. Males were predominantly affected (63.8%). The majority of the victims were in the 3rd decade (40.0%) of life. The age of the victims ranged from 2 to 82 years with a mean age of 38.4 years. Agrochemical compounds were implicated in 44.4% of the total fatalities.

Conclusion:
Males in the 2nd to 4th decades of life were more prone to self-poisoning with Agrochemical compounds in the region of North India. Accidental poisoning deaths were uncommon and poisoning was not a preferred method of homicide in this region. Our approach to the study reveals that quantitative chemical (toxicological) analysis is required to further strengthen and improve the databases of the epidemiology of poisoning in this region.
Correlation of dental caries status with BMI in school children of age 3-16 years- An institutional study
Authors: Talluri Devaki , Panga Gnana Sarita Kumari , Shaik Parveen S. , Pavani Nijampatnam P. M. , Yaddanapalli Suresh C. , Bommireddy Vikram Simha , Bhavani Vasamsetti D. 
Published: April 2023

ABSTRACT

Aim:
The study investigates the correlation of dental caries status with body mass index (BMI) in school children of age 3 to 16 years.

Background:
Obesity is a rising global health epidemic. Dental caries has been the predominant disorder in modern society. Obesity and dental caries are major health problems with multifactorial characteristics and similar risk factors, such as diet, lack of physical activity, unhealthy eating pattern, not enough sleep, and high amount of stress etc. Various studies have documented diverse outcomes linked to BMI and dental caries.

Material and Methods:
A cross-sectional study was implemented on 756 participants. Among the study participants, 475 (62.8%) were boys and 281 (37.2%) were girls. The decayed, missing and filled teeth (DMFT) index has been used to assess the prevalence of dental caries. Information of the study participant’s height and weight was reported using a standardized measuring scale and weighing machine; after that, the BMI was measured. SPSS version 22 was used to analyze the data.

Results:
The mean DMFT of the study participants in normal-weight children was 2.3. There was a positive correlation between the dental caries status and BMI, with a significant value of 0.27.

Conclusion:
Diet counselling and regular dental check-ups should be prescribed to prevent dental caries from occurring and monitor children’s healthy weight. Balanced nutrition needs to be provided to children by school authorities and parents.
Regional assessment of medical care provision system by principal component analysis
Authors: Ohashi Kazuki , Abe Arisa , Fujiwara Kensuke , Nishimoto Naoki , Ogasawara Katsuhiko 
Published: April 2023

ABSTRACT

Introduction:
The Japanese government has promoted policies ensuring standardized medical care across the secondary medical care areas (SMCAs); however, these efforts have not been evaluated, making the current conditions unclear. Multidimensional indicators could identify these differences; thus, this study examined the regional characteristics of the medical care provision system for 21 SMCAs in Hokkaido, Japan, and the changes from 1998 to 2018.

Materials and Methods:
This study evaluated the characteristics of SMCAs by principal component analysis using multidimensional data related to the medical care provision system. Factor loadings and principal component scores were calculated, with the characteristics of each SMCA visually expressed using scatter plots. Additionally, data from 1998 to 2018 were analyzed to clarify the changes in SMCAs’ characteristics.

Results:
The primary and secondary principal components were Medical Resources and Geographical Factors, respectively. The Medical Resources components included the number of hospitals, clinics, and doctors, and an area’s population of older adults, accounting for 65.28% of the total variance. The Geographical Factors components included the number of districts without doctors and the population and a land area of these districts, accounting for 23.20% of the variance. The accumulated proportion of variance was 88.47%. From 1998 to 2018, the area with the highest increase in Medical Resources was Sapporo, with numerous initial medical resources (−9.283 to −10.919).

Discussion:
Principal component analysis summarized multidimensional indicators and evaluated SMCAs in this regional assessment. This study categorized SMCAs into four quadrants based on Medical Resources and Geographical Factors. Additionally, the difference in principal component scores between 1998 and 2018 emphasized the expanding gap in the medical care provision system among the 21 SMCAs.