bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between ethical position and whistleblowing: A cross‐sectional study among nurses
Authors: Çekiç Yasemin , Tuna Rujnan , Eskin Bacaksiz Feride 
Published: December 2022

AbstractAim and ObjectivesThe aim of this study is to determine nurses' ethical positions, whistleblowing intention and its causes, and to analyse the correlation between them, while revealing the personal and professional characteristics causing significant difference.BackgroundIn today's challenging healthcare settings, ethical dilemmas are inherent to nursing practices, leading to situations whereby nurses must consider whistleblowing and reasons such as reporting medical errors or misbehaviors.DesignThe study is descriptive, cross‐sectional and correlational.MethodsThe data were collected from a convenience sample consisting of 294 nurses between 1 April and 30 June 2019, in four hospitals in two cities. An introductory information form, Ethics Position Questionnaire, Whistleblowing Scale and Causes of Whistleblowing Scale were employed to collect data. The data were analysed with descriptive, correlational, comparative and internal consistency analyses (Guidelines for reporting cross‐sectional studies (Data )).ResultsIt was found that nurses encountered (31.3%) and reported (85.9%) unethical incidents. According to the subscales, they obtained higher scores from idealism (4.37 ± 0.52), supportive whistleblowing (3.75 ± 0.72), and moral and professional values (3.77 ± 0.67). The Ethics Position Questionnaire, as well as the Whistleblowing Scale (r = .302) and the Causes of Whistleblowing Scale (r = .211) had a positive weak correlation (p < .001). Nurses' age, marital status, and professional and institutional experiences all created a significant difference (p < .05).ConclusionsThe nurses mostly encountered unethical incidents associated with management. The rates of reporting the unethical incidents were high, and they were found not hesitating to report using whistleblowing, yet intended to keep the incidents within the institution. In addition, idealistic nurses were more likely to whistleblow, and their causes for whistleblowing were mostly associated with moral and professional values.Relevance to Clinical PracticeIt is recommended that nurses' ethical position, and whistleblowing intentions and causes should be supported and improved through the corporate culture.
Analysis of the guidance and predictive value of uterine artery flow parameters in patients with recurrent spontaneous abortion
Authors: Lian Xiaolu , Pan Zhansheng , Xia Fei , Mao Caiping , Zhou Weiqin , Zhong Yanyu , Zhou Ying 
Published: December 2022

AbstractObjectiveTo analyze the uterine artery blood flow parameters of patients with recurrent spontaneous abortion (RSA) at different gestational ages and to investigate the effects of aspirin and low molecular weight heparin (LMWH) on uterine artery blood flow parameters and pregnancy outcomes.MethodsThis was a retrospective cohort study involving analysis of clinical data for 140 patients: 47 in an aspirin group, 49 in a combination group, and 44 in a control group. The uterine artery blood flow parameters of the three groups in the middle luteal period and 10th, 12th, 16th, and 20th gestational weeks were compared. Trends in uterine artery flow parameters were predicted by function fitting, and the uterine artery flow parameters and pregnancy outcomes between different drug administration regimens were compared.ResultsWith increasing gestational age, the uterine artery blood flow parameters of the three groups gradually decreased. In the middle luteal phase, the uterine artery blood flow parameters (mRI, mPI, mS/D) of the recurrent spontaneous abortion group, that is, the aspirin and combination groups, were significantly higher than those of the control group. Uterine artery blood flow parameters from 10 to 20 weeks of gestation were as follows: combined group < aspirin group < normal pregnancy group. The mean resistance index (mRI) in the combination group decreased most rapidly compared with the aspirin group between 10 and 20 weeks of gestation. The live birth rate was higher in the combination group than in the aspirin group.ConclusionsBoth aspirin and aspirin combined with LMWH can reduce uterine artery blood flow parameters, and combination therapy is superior to aspirin alone. In the RSA group, the rate of mRI decline may predict pregnancy outcome to some extent. Combination therapy can improve the live birth rate and reduce the miscarriage rate.
Measuring Implementation of Health Promoting School (HPS) Programs: Development and Psychometric Evaluation of the HPS Implementation Questionnaire
Authors: Vennegoor Gerjanne , Van Assema Patricia , Eekhout Iris , Lezwijn Jeanette , Molleman Gerard , Jansen Maria 
Published: December 2022

ABSTRACTBACKGROUNDImplementation of Health Promoting School (HPS) programs can be challenging due to the dynamic school context. Navigating between program fidelity and adaptation, as well as integrating the program, is essential for successful implementation, and consequently, for program effects. As part of an evaluation study in the Netherlands, this study aimed to develop a measurement instrument that differentiates schools according to fidelity, adaptation, and integration of HPS implementation.METHODSThis study presents the development and psychometric evaluation of the 28‐item HPS Implementation Questionnaire, covering 7 dimensions: adherence, dose, participant responsiveness, quality of delivery, program differentiation, adaptation, and integration. The questionnaire, to be filled out by school employees, was developed for primary, secondary, secondary vocational, and special needs education, in close collaboration with experts (n = 54) in school health promotion.RESULTSSemi‐structured interviews aimed at dimension clarification resulted in a list of 58 items. Items were revised, combined, and/or removed based on quantitative and qualitative feedback by the evaluation study's Community of Practice, 2‐round expert consultation, and pre‐tests. Psychometric evaluation (n = 535 schools), consisting of calculating Cronbach's α and confirmatory factor analysis (CFA), confirmed internal consistency (α > .72) and the 7‐dimension framework.CONCLUSIONThe brief yet comprehensive HPS Implementation Questionnaire offers possibilities for research into HPS implementation in various educational sectors and contexts, as well as self‐monitoring by individual schools. This study provides first evidence for internal consistency and validity of the questionnaire.
Crisis resolution home treatment team Clinicians' perceptions of using a recovery approach with people with a diagnosis of borderline personality disorder
Authors: Taylor Tracy , Stockton Stephanie , Bowen Matt 
Published: December 2022

Accessible SummaryWhat is known on the subject?

It is known that people with a diagnosis of borderline personality disorder often experience crises in their mental wellbeing.

There is little evidence about the approaches of mental health nurses in community‐based crisis teams when working with people with a diagnosis of BPD.

What the paper adds to the existing knowledge?

This paper highlights that limited resources, work‐patterns and issues of stigma present challenges to delivering recovery‐oriented care.

The paper highlights that nurses typically try to navigate the challenges to continue to provide individualized care, though their self‐assessment is that this is with mixed success.

What are the implications for practice?

The findings suggest that support is needed to develop brief interventions specific to teams working with people with a diagnosis of BPD who are at a point of crisis.

AbstractIntroductionPeople with a diagnosis of borderline personality disorder (BPD) are often in contact with mental health services at a point of crisis, and in the UK, this includes Crisis Resolution Home Treatment teams (CRHTT). There is a drive for services to be recovery orientated; however, there is little evidence about the degree to which community services achieve this for people with a diagnosis of BPD when in crisis.Research AimTo understand the perceptions held by CRHTT clinicians about their provision of recovery‐orientated acute care, for people with a diagnosis of BPD.MethodFrom a purposive sample of a single CRHTT, seven registered mental health nurses were interviewed and Braun and Clarke's thematic analysis framework was used to interpret the data.ResultsFive themes emerged: person‐centred care; the timing is wrong; inconsistent staffing; the risks are too great; and BPD as a label.DiscussionThe results demonstrate tensions between a drive to deliver person‐centred care and a range of challenges that inhibit this, with the possibility of reframing a recovery approach as “recovery‐ready”.Implications for PracticeA whole‐system approach is required to enable a consistent recovery‐oriented approach, but research is also needed for brief interventions specific to this context.
Mental health status of mental health nurses in China: Results from a national survey
Authors: Wang Peicheng , Tang Yi‐lang , Chen Yanhua , He Yanrong , Li Lin , Han Xinxin , Liu Yuanli , Liu Tingfang , Liu Huanzhong , Jiang Feng , Zhu Jiming 
Published: December 2022

AbstractIntroductionIt has been acknowledged in China that actions should be taken immediately to ease the critical shortage of psychiatric nurses. However, with national data lacking, little is known about nurses' mental health status.AimTo evaluate psychiatric nurses' mental health status by measuring their burnout, depression, anxiety and stress.MethodsAll psychiatric nurses in the 41 selected hospitals in China were invited to participate in the survey. The Maslach Burnout Inventory‐Human Service Survey and Depression Anxiety Stress Scale were used to assess variables of interest.Results38.6% of psychiatric nurses met the criteria for burnout. The rates of depression, anxiety and stress were 26.3%, 36.4% and 12.5%, respectively. It was found that workplace region, educational level, working years, longer working hours and night shifts were associated with risk of burnout and DASS.ConclusionsMore than a quarter of psychiatric nurses are suffering from burnout, depression or anxiety in China. Policymakers and hospital administrators should design a flexible schedule and restrict working hours for psychiatric nurses to achieve work‐life balance.Implications for PracticeThe study informs policymakers and administrators on addressing the nursing shortage by identifying nurses immersed in negative emotions and preventing mental health problems.
Lipocalin 2, synthesized using a cell‐free protein synthesis system and encapsulated into liposomes, inhibits the adhesion of Porphyromonas gingivalis to human oral epithelial cells
Authors: Kido Jun‐ichi , Hiroshima Yuka , Kido Rie , Yoshida Kaya , Inagaki Yuji , Naruishi Koji , Kajimoto Kazuaki , Kataoka Masatoshi , Shinohara Yasuo , Yumoto Hiromichi 
Published: December 2022

AbstractBackground and ObjectiveLipocalin 2 (LCN2), a glycoprotein expressed in epithelial cells and leukocytes, has an antibacterial effect and plays a role in innate immunity. The delivery of LCN2 encapsulated in liposomes to oral epithelium may be useful to prevent oral infectious diseases. This study aimed to investigate the inhibitory effect of LCN2, artificially synthesized using a cell‐free protein synthesis (CFPS) system, on the adhesion of Porphyromonas gingivalis to oral epithelial cells in order to approach oral healthcare using LCN2.MethodsLCN 2 was synthesized using a CFPS system and assayed by Western blotting, mass spectrometry and enzyme‐linked immunosorbent assay (ELISA). The bilayer liposomes were prepared by the spontaneous transfer method using 1,2‐dioleoyl‐sn‐glycero‐3 phosphocholine (DOPC), 3‐sn‐phosphatidylcholine from Egg Yolk (Egg‐PC), and 1,2‐dioleoyl‐sn‐glycero‐3 phosphoethanolamine (DOPE). The cellular and medium fractions derived from the culture of oral epithelial cells with liposome‐encapsulated LCN2 were assayed by Western blotting and ELISA. The effect of the synthesized LCN2 on adhesion of the labeled P. gingivalis to oral epithelial cells was investigated as an evaluation of its antibacterial activity.ResultsThe synthesized LCN2 protein was identified by Western blotting; its amino acid sequence was similar to that of recombinant LCN2 protein. The additions of DOPE and octa‐arginine in the outer lipid‐layer components of liposome significantly increased the delivery of liposomes to epithelial cells. When oral epithelial cells were cultured with the synthesized and liposome‐encapsulated LCN2, LCN2 was identified in the cellular and medium fractions by Western blotting and its concentration in the cellular fraction from the culture with the synthesized LCN2 was significantly higher than that of a template DNA‐free protein. The synthesized LCN2 and liposome‐encapsulated LCN2 significantly inhibited the adhesion of P. gingivalis to oral epithelial cells compared with template DNA‐free protein.ConclusionLCN2 was artificially synthesized by a CFPS system, encapsulated in liposomes, and delivered to oral epithelial cells, and demonstrated an antibacterial action against P. gingivalis. This approach may become a useful model for oral healthcare.
Age‐related changes in autonomic response: A pupillary light reflex and heart rate variability study
Authors: Bril Paroz Roberta , Barak Lanciano Sapir , Omelchenko Alex , Nussinovitch Udi 
Published: December 2022

AbstractBackgroundAutonomic nervous system (ANS) dysfunction has been implicated with cardiovascular diseases, sudden‐cardiac‐death, and aging. The pupillary light reflex (PLR) and heart rate variability (HRV) are noninvasive tools of autonomic evaluation. However, the former remains underutilized in clinical practice.PurposeWe investigated the relationship between PLR, HRV, and aging to determine the normal distribution of age‐adjusted PLR and HRV measurements and to determine which method is best correlated with age.MethodsHealthy participants aged 18–65 years were recruited. Following a dark adaptation period, pupillary reactivity parameters were collected using an automated, commercial pupillometer. HRV measurements were derived using a high‐resolution electrocardiogram. Correlations of PLR and HRV parameters to age were computed using linear‐regression analysis.ResultsA total of 111 healthy participants were included. Older age was correlated with lower maximum and minimum pupillary diameters following dark adaptation and illumination (R = −0.51, p < 0.001 and R = −0.47, p < 0.001, respectively). Average constriction and dilatation velocity were correlated with age (R = 0.33, p < 0.001 and R = −0.21, p = 0.025, respectively). HRV parameters were also associated inversely with age (SDNN; R = −0.31, p < 0.001 and RMSSD; R = −0.33, p < 0.001). Other parameters showed lower significance levels.ConclusionPupillary light reflex measurements demonstrated stronger age correlation than short‐term HRV time‐domain indices. Due to its merit in depicting normal age‐related ANS changes, PLR can be utilized to differentiate between pathological and physiological deviations from age‐adjusted norms, seemingly better than HRV. Further research is warranted on incorporating PLR‐based ANS dysfunction evaluation and monitoring the increasingly aging population.
Greed is good: Heuristic adaptations for resilience in renewable resource management
Authors: Ni Yuanming , Sandal Leif K. , Kvamsdal Sturla F. 
Published: December 2022

AbstractDecision problems may be subject to objectives or constraints that make the formal model intractable. We propose an adaptive and pragmatic approach to address such nonstandard objectives or constraints, where these are first circumvented for feasibility, then accounted for through heuristics. One example is managing risk and resilience in a natural system facing uncertainty. Our procedure is exemplified in a predator‐prey fisheries system where a reference policy that maximizes expected profits implies a risk of prey stock collapse. The reference policy includes a no‐fishing section for the prey and harvest beyond myopic catch for the predator in parts of state space. We construct heuristic recovery plans, based on the reference policy, to reduce the risk of collapse by partly backing in the auxiliary objective. Under the heuristic policies, system resilience is enhanced with limited economic losses. Via Monte Carlo simulations, we calculate viability probabilities as measures of improved resilience and employ dynamic programming to assess value losses.
Classification and surgical treatment methods for partial traumatic upper lip deformity
Authors: Gao Ya , Wang Jian , Gao Zhen , Zhou Jia 
Published: December 2022

AbstractObjectivesEstablish a classification method for partial traumatic upper lip deformity and verify the classified repair method is superior to the traditional non‐classified method.Subjects and MethodsLip deformities caused by partial tissue defects of less than one‐third of total lip length were classified into three types and conducted corresponding surgery based on philtrum ridge and orbicularis oris muscle involvement as well as the extent of roll line discontinuity. In this review, 42 cases were non‐classified historical controls before the classification was devised, and 67 cases were classified. Data were collected 12 months after surgery. The pre‐ and post‐operative data of all patients were compared.ResultsIn classified patients, the scar width decreased significantly, from 3.1 ± 0.6 mm to 1.2 ± 0.2 mm; the height difference of the groove line was significantly reduced from 3.3 ± 0.9 mm to 0.9 ± 0.1 mm; the ratio of the vermilion area of the affected to healthy side decreased significantly from 1.37 ± 0.31 to 1.05 ± 0.17; the ratio of the lip peak height of the affected to healthy side in type III decreased significantly from 1.91 ± 0.32 to 1.07 ± 0.12; patient satisfaction rate was about 98.5 percent.ConclusionsClinical outcomes showed significant improvement of lip aesthetics with a high patient satisfaction rate in the classified group than the non‐classified group.
Lower masticatory function relates to cognitive health and intrinsic brain network in older adults
Authors: Lin Chia‐Shu , Chang Wen‐Ju , Fuh Jong‐Ling 
Published: December 2022

AbstractObjectivesMastication is associated with brain activation at the primary somatosensory cortex (S1) and the primary motor cortex (M1). Masticatory functions differ between patients with cognitive impairment (CI) and cognitively healthy older adults (non‐CI). The association between cognitive health, brain network of functional connectivity, and mastication has remained unknown. The study investigated the association between masticatory performance (MP) and the topological feature of the functional network at the M1 and S1 in the CI and non‐CI groups.Subjects and MethodsForty‐nine non‐CI and 15 CI subjects received resting‐state (rs) fMRI and assessment of MP. The topological feature of the M1 and S1 was quantified by eigenvector centrality (EC), an index that reflects a brain region as a functional “hub” of brain network.ResultsIn the non‐CI group, MP was significantly correlated with EC of the left M1 and the right M1. The correlation was not statistically significant in the CI group. Cognitive status (CI or non‐CI) and EC of the left M1 and the right M1, respectively, were statistically significant predictors to individual MP.ConclusionCognitive status and the topological feature of the M1 in the intrinsic functional network may contribute to the individual difference in masticatory function.
Association between axial spondyloarthritis and temporomandibular disorders: A systematic review
Authors: de Melo‐Silva Elma Mariana Verçosa , Valdez Remberto Argandoña , da Barbosa‐Silva Izabella Maria , Chateaubriand Marina Moura , Duarte Angela Luzia Branco Pinto , Gueiros Luiz Alcino 
Published: December 2022

AbstractThis study aimed to assess the frequency of temporomandibular disorders (TMDs) in patients with axial spondyloarthritis (axSpA) compared with the healthy individuals. We systematically searched PubMed, Embase, Scopus, Web of Science, CINAHL, and Google Scholar databases from their inception until 2022, without language restriction. A standardized dataset was used to extract data from the observational studies. Patients were required to have axial spondyloarthritis and clinical and/or radiographic evidence of temporomandibular joint dysfunction. Meta‐analysis was performed with a random effects model. A systematic review was registered under number CRD42020206283. We identified seven relevant studies, which provided data for 745 patients and 216 temporomandibular disorders events. The combined odds ratio (OR) showed that the risk of temporomandibular disorders in individuals with axial spondyloarthritis was higher than the control group (pooled OR = 5.26, 95% CI 2.50–11, 06; p < 0.02; I2 = 58%). Also, these individuals do not appear to refer possible temporomandibular joint symptoms to the rheumatologist or dentist. The results of this systematic review and meta‐analysis suggest that patients with axial spondyloarthritis have an increased frequency of temporomandibular disorders. TMDs seem to be secondary to postural alterations rather than direct involvement of the temporomandibular joints (TMJs).
Chemoproteomic profiling of O‐GlcNAcylated proteins and identification of O‐GlcNAc transferases in rice
Authors: Li Xilong , Lei Cong , Song Qitao , Bai Lin , Cheng Bo , Qin Ke , Li Xiang , Ma Boyuan , Wang Bing , Zhou Wen , Chen Xing , Li Jiayang 
Published: December 2022

SummaryO‐linked β‐N‐acetylglucosaminylation (O‐GlcNAcylation) is a ubiquitous post‐translation modification occurring in both animals and plants. Thousands of proteins along with their O‐GlcNAcylation sites have been identified in various animal systems, yet the O‐GlcNAcylated proteomes in plants remain poorly understood. Here, we report a large‐scale profiling of protein O‐GlcNAcylation in a site‐specific manner in rice. We first established the metabolic glycan labelling (MGL) strategy with N‐azidoacetylgalactosamine (GalNAz) in rice seedlings, which enabled incorporation of azides as a bioorthogonal handle into O‐GlcNAc. By conjugation of the azide‐incorporated O‐GlcNAc with alkyne‐biotin containing a cleavable linker via click chemistry, O‐GlcNAcylated proteins were selectively enriched for mass spectrometry (MS) analysis. A total of 1591 unambiguous O‐GlcNAcylation sites distributed on 709 O‐GlcNAcylated proteins were identified. Additionally, 102 O‐GlcNAcylated proteins were identified with their O‐GlcNAcylation sites located within serine/threonine‐enriched peptides, causing ambiguous site assignment. The identified O‐GlcNAcylated proteins are involved in multiple biological processes, such as transcription, translation and plant hormone signalling. Furthermore, we discovered two O‐GlcNAc transferases (OsOGTs) in rice. By expressing OsOGTs in Escherichia coli and Nicotiana benthamiana leaves, we confirmed their OGT enzymatic activities and used them to validate the identified rice O‐GlcNAcylated proteins. Our dataset provides a valuable resource for studying O‐GlcNAc biology in rice, and the MGL method should facilitate the identification of O‐GlcNAcylated proteins in various plants.