bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current ethical dilemmas experienced by therapists who use social media: A systematic review
Authors: White Ella , Hanley Terry 
Published: July 2023

AbstractBackgroundDespite the rise in therapist use of social media, current ethical guidelines have not provided clear guidance on how to use social media. Ethical guidelines commonly suggest therapists apply the same ethical principles advised for their offline work, without thorough consideration of differing potential ethical dilemmas online.MethodsA systematic review was conducted to explore the main ethical dilemmas encountered by therapists who use social media. Three databases were searched: PsycINFO, Web of Science and CINAHL Plus. A total of 52 studies were screened by their titles and abstracts, with a subsequent 36 studies analysed against inclusion and exclusion criteria. The remaining 14 studies were assessed using quality standards and included within the thematic synthesis.FindingsData analysis conceptualised three themes: therapist searches risking the therapeutic relationship with subthemes of loss and trust and power imbalance; therapist defensiveness in response to client searches with subthemes of self‐disclosure and self‐protection; and societal normalisation of social media with subthemes of familiarity and ease and blurred boundaries.ConclusionThe societal prevalence of social media use suggests it is now inevitable that therapists will experience some form of ethical dilemma regarding social media. Therapists need an awareness of how online searches for clients may impact the therapeutic relationship. The risk of boundary crossings from clients online can be minimised through increased privacy settings and reflexivity on what therapists self‐disclose online. Ethical dilemmas on social media should be discussed in supervision, with further guidance needed for the ethical use of social media as a therapist.
Composition, Antibiofilm, and Antibacterial Potential of Volatile Oils from Geopropolis of Different Stingless Bees’ Species**
Authors: Storch Portal Ariane , Schiquet Scarlet , Padilha Amaral Bruna , Mascarenhas Krepsky Larissa , Curbani Luana , Andrade Rebelo Ricardo , Rau Martinho , Althoff Sérgio Luís , Guedes Alessandro , Mendes de Cordova Caio Maurício 
Published: July 2023

AbstractWe aimed to characterize and investigate the antibacterial potential of the native stingless bees geopropolis volatile oils (VO) for the search of potentially new bioactive compounds. Geopropolis samples from Melipona bicolor schencki, M. compressipes manaosensis, M. fasciculata, M. quadrifasciata, M. marginata and M. seminigra merrillae were collected from hives in South Brazil. VO were obtained by hydrodistillation and characterised by gas chromatography coupled to mass spectrometry (GC/MS). Antimicrobial activity was assessed by microplate dilution method. The lowest MIC against cell walled bacteria was 219±0 μg mL−1 from M. quadrifasciata geopropolis VO with Staphylococcus aureus. The M. b. schencki geopropolis VO minimal inhibition concentration (MIC) was 424±0 μg mL−1 against all the mycoplasma strains evaluated. Fractionation resulted in the reduction of 50 % of the MIC value from the original oil. However, its compounds’ synergism seems to be essential to this activity. Antibiofilm assays demonstrated 15.25 % eradication activity and 13.20 % inhibition of biofilm formation after 24 h for one subfraction at 2× its MIC as the best results found. This may be one of the essential mechanisms by which geopropolis VOs perform their antimicrobial activity.
Gas Permeation through Mechanically Resistant Self‐Standing Membranes of a Neat Amorphous Organic Cage
Authors: Mobili Riccardo , La Cognata Sonia , Monteleone Marcello , Longo Mariagiulia , Fuoco Alessio , Serapian Stefano A. , Vigani Barbara , Milanese Chiara , Armentano Donatella , Jansen Johannes C. , Amendola Valeria 
Published: July 2023

AbstractThe synthesis and characterization of a novel film‐forming organic cage and of its smaller analogue are here described. While the small cage produced single crystals suitable for X‐ray diffraction studies, the large one was isolated as a dense film. Due to its remarkable film‐forming properties, this latter cage could be solution processed into transparent thin‐layer films and mechanically stable dense self‐standing membranes of controllable thickness. Thanks to these peculiar features, the membranes were also successfully tested for gas permeation, reporting a behavior similar to that found with stiff glassy polymers such as polymers of intrinsic microporosity or polyimides. Given the growing interest in the development of molecular‐based membranes, for example for separation technologies and functional coatings, the properties of this organic cage were investigated by thorough analysis of their structural, thermal, mechanical and gas transport properties, and by detailed atomistic simulations.
Direct Amination of Benzene with Ammonia by Flow Plasma Chemistry
Authors: Dupont Victor , Ognier Stéphanie , Morand Gabriel , Ollivier Cyril , Fensterbank Louis , Tatoulian Michael 
Published: July 2023

AbstractAmine derivatives, including aniline and allylic amines, can be formed in a single‐step process from benzene and an ammonia plasma in a microreactor. Different process parameters such as temperature, residence time, and plasma power were evaluated to improve the reaction yield and its selectivity toward aminated products and avoid hydrogenated or oligomerized products. In parallel, simulation studies of the process have been carried out to propose a global mechanism and gain a better understanding of the influence of the different process parameters. The exploration of diverse related alkenes showed that the double bonds, conjugation, and aromatization influenced the amination mechanism. Benzene was the best reactant for amination based on the lifetime of radical intermediates. Under optimized conditions, benzene was aminated in the absence of catalyst with a yield of 3.8 % and a selectivity of 49 % in various amino compounds.
A Rising Star: Luminescent Carbene‐Metal‐Amide Complexes
Authors: Ying Ao , Gong Shaolong 
Published: July 2023

AbstractCoinage metal (gold, silver, and copper) complexes are attractive candidates to substitute the widely studied noble metal complexes, such as, iridium(III) and platinum(II), as luminescent materials in organic light‐emitting diodes (OLEDs). However, the development of coinage metal complexes exhibiting high emission quantum yields and short exciton lifetimes is still a formidable challenge. In the past few years, coinage metal complexes featuring a carbene‐metal‐amide (CMA) motif have emerged as a new class of luminescent materials in OLEDs. Thanks to the coinage metal‐bridged linear geometry, coplanar conformation, and the formation of excited states with dominant ligand‐to‐ligand charge transfer character and reduced metal d‐orbital participation, most CMA complexes have high radiative rates via thermally activated delayed fluorescence. Currently, the family of CMA complexes have rapidly evolved and remarkable progresses in CMA‐based OLEDs have been made. Here, a Concept article on CMA complexes is presented, with a focus on molecular design principles, the correlation between molecular structure/conformation and optoelectronic properties, as well as OLED performance. The future prospects of CMA complexes are also discussed.
Light‐, Middle‐ and Heavy‐Lanthanide Ate‐Complexes Bearing Ln(III)–Si bonds: Structural, Spectroscopic, and Bonding Analysis
Authors: Pan Xiaowei , Wu Changjiang , Fang Huayi , Yan Chunhua 
Published: July 2023

Comprehensive SummaryRecent decades have witnessed a rapid development of the lanthanide silicon chemistry. In this research, by reacting [(THF)3LiSiPh3] with Cp3Ln(III)(THF) (Ln(III) = Sm(III), Tb(III), Dy(III), Yb(III)) or Cp2Lu(III)Cl(THF), a series of middle‐ and heavy‐lanthanocene monosilyl/disilyl ate‐complexes ([(DME)3Li][Cp3Ln(III)SiPh3] and [(DME)3Li][Cp2Lu(III)(SiPh3)2]) were synthesized. The structures of the obtained lanthanocene monosilyl/disilyl ate‐complexes were determined by single crystal X‐ray diffraction. Together with the previously reported [(DME)3Li][Cp3La(III)SiPh3] and [(DME)3Li][Cp3Ce(III)SiPh3], a complex group comprising silyl light‐, middle‐ and heavy‐lanthanocene with identical core coordination pattern are presented. The structure analysis of this group of complexes showed that their key geometric parameters, including the Ln(III)–Si bond lengths and Ln(III)–Si–Cph/Cph–Si–Cph angles, were linearly correlated with the ionic radii of Ln(III) centers. Computational studies based on density functional theory calculations suggested the strongly polarized nature of the Ln(III)–Si bonds in these ate‐complexes. The UV‐Vis spectroscopy measurements of this group of ate‐complexes showed that the characteristic absorptions were hypsochromically shifted for complexes with heavier Ln(III) centers. In addition, as revealed by the time‐dependent density functional theory analysis, the HOMOs, in which the Ln(III)–Si σ‐bonding orbitals were the dominant components, of these complexes acted as main donor orbitals in the major electron transitions.
A combined moment equation approach for spatial autoregressive models
Authors: Liu Jiaxin , Liu Hongliang , Li Yi , Lin Huazhen 
Published: July 2023

AbstractExisting methods for fitting spatial autoregressive models have various strengths and weaknesses. For example, the maximum likelihood estimation (MLE) approach yields efficient estimates but is computationally burdensome. Computationally efficient methods, such as generalized method of moments (GMMs) and spatial two‐stage least squares (2SLS), typically require exogenous covariates to be significant, a restrictive assumption that may fail in practice. We propose a new estimating equation approach, termed combined moment equation (COME), which combines the first moment with covariance conditions on the residual terms. The proposed estimator is less computationally demanding than MLE and does not need the restrictive exogenous conditions as required by GMM and 2SLS. We show that the proposed estimator is consistent and establish its asymptotic distribution. Extensive simulations demonstrate that the proposed method outperforms the competitors in terms of bias, efficiency, and computation. We apply the proposed method to analyze an air pollution study, and obtain some interesting results about the spatial distribution of PM2.5 concentrations in Beijing.
Assessment of longitudinal changes in body composition of children with lymphoma and rhabdomyosarcoma
Authors: Wadhwa Aman , Lim Shawn , Dai Chen , Daniels Gabriel , Adams Kandice , Richman Joshua S. , McDonald Andrew , Williams Grant R. , Bhatia Smita 
Published: July 2023

AbstractBackgroundStudies examining changes in skeletal muscle and adipose tissue during treatment for cancer in children, adolescents, and young adults and their effect on the risk of chemotherapy toxicity (chemotoxicity) are limited.MethodsAmong 78 patients with lymphoma (79.5%) and rhabdomyosarcoma (20.5%), changes were measured in skeletal muscle (skeletal muscle index [SMI]; skeletal muscle density [SMD]) and adipose tissue (height‐adjusted total adipose tissue [hTAT]) between baseline and first subsequent computed tomography scans at the third lumbar vertebral level by using commercially available software. Body mass index (BMI; operationalized as a percentile [BMI%ile]) and body surface area (BSA) were examined at each time point. The association of changes in body composition with chemotoxicities was examined by using linear regression.ResultsThe median age at cancer diagnosis of this cohort (62.8% male; 55.1% non‐Hispanic White) was 12.7 years (2.5–21.1 years). The median time between scans was 48 days (range, 8–207 days). By adjusting for demographics and disease characteristics, this study found that patients undergo a significant decline in SMD (β ± standard error [SE] = −4.1 ± 1.4; p < .01). No significant changes in SMI (β ± SE = −0.5 ± 1.0; p = .7), hTAT (β ± SE = 5.5 ± 3.9; p = .2), BMI% (β ± SE = 4.1 ± 4.8; p = .3), or BSA (β ± SE = −0.02 ± 0.01; p = .3) were observed. Decline in SMD (per Hounsfield unit) was associated with a greater proportion of chemotherapy cycles with grade ≥3 nonhematologic toxicity (β ± SE = 1.09 ± 0.51; p = .04).ConclusionsThis study shows that children, adolescents, and young adults with lymphoma and rhabdomyosarcoma undergo a decline in SMD early during treatment, which is associated with a risk of chemotoxicities. Future studies should focus on interventions designed at preventing the loss of muscle during treatment.Plain Language Summary

We show that among children, adolescents, and young adults with lymphoma and rhabdomyosarcoma receiving chemotherapy, skeletal muscle density declines early during treatment.
Additionally, a decline in skeletal muscle density is associated with a greater risk of nonhematologic chemotoxicities.
Association of habitual sleep duration and its trajectory with the risk of cancer according to sex and body mass index in a population‐based cohort
Authors: Ning Deng , Fang Yuanyuan , Zhang Wanguang 
Published: July 2023

AbstractBackgroundThe relationship between sleep duration and cancer in China remains inconclusive. The authors investigated the association between sleep duration and cancer from both static and dynamic perspectives.MethodsThis study was based on the China Health and Retirement Longitudinal Study. We first tested the hazard ratios (HRs) with 95% confidence intervals (CIs) between baseline sleep duration and incident cancer using Cox proportional hazards regression analysis. Sleep duration trajectories from 2011 to 2015 were identified using group‐based trajectory modeling to examine the subsequent risk of incident cancer from 2015 to 2018 using Cox proportional hazards regression model.ResultsThe risk of incident cancer increased by 69% (HR, 1.69; 95% CI, 1.19–2.39) in individuals who slept for <7 h per day (vs. 7 to ≤8 h), 41% (HR, 1.41; 95% CI, 1.01–1.95) in those who slept for <6 h per night (vs. 6 to ≤8 h), and 60% (HR, 1.60; 95% CI, 1.01–2.55) in those who did not take any naps during the day (vs. >60 min). Stratified by sex and body mass index, the risk of cancer was evident among women with night sleep of <6 h (vs. 6–8 h). However, the duration of <7 h of total sleep among men and overweight individuals was associated with cancer risk. Moreover, individuals with a short night sleep duration but no napping had a higher risk of cancer. Furthermore, cancer risk was only observed in individuals with short stable trajectory of night sleep (HR, 2.01; 95% CI, 1.07–3.80) and among women with short stable trajectory of total sleep (HR, 2.26; 95% CI, 1.13–4.52).ConclusionsCancer incidence risk was observed in participants with sleep duration of <7 h and among women with short stable sleep trajectory. Short nights and total sleep duration were both associated with a high risk of incident cancer, but varied by sex. Interestingly, cancer risk was restricted to women with short stable sleep trajectory.Plain Language Summary

This study showed that short nights and total sleep duration were associated with a high risk of cancer incidence in middle‐aged and elderly Chinese population, with implications for early effective cancer prevention.
Habitual sleep is a modifiable and dynamic lifestyle behavior, and long‐term short sleep trajectories among women can predict cancer outcomes.
Future studies should examine the association between the trajectory of sleep parameters based on objective measures and specific cancer types.
Trends in participant race and sex reporting in lung cancer phase III clinical trials
Authors: Aslam Faaiq N. , Manochakian Rami , Lou Yanyan , Colon‐Otero Gerardo , Sher Taimur 
Published: July 2023

AbstractBackgroundClinical trials are an essential part of advancing care for cancer patients. Historically, however, racial minorities and females have been underrepresented in these trials. Efforts like the National Institute of Health Revitalization Act attempted to mitigate these disparities, but despite these efforts, they continue to exist. These disparities can subsequently lead to minorities and females receiving suboptimal care.AimsThe purpose of our study was to understand the changing trends in reporting of participant race and sex as a demographic variable in phase III lung cancer clinical trials published over the last 35 years given these consequences of poor representation.Methods and resultsA total of 426 articles reporting the results of phase III lung cancer clinical trials published from 1984 to 2019 were identified in PubMed. From these articles, data on participant sex and race were collected from the demographic tables to construct the database for this study. This database was subsequently used to determine the rate of reporting of demographic factors like race and sex and the participation trends over the time of minority and female participation in lung cancer phase III clinical trials. The SciPy Stats package for Python was used to calculate descriptive statistics, 95% confidence intervals, two sample t‐test, one‐way analysis of variance test, and Pearson's correlation coefficients. The Matplotlib package for Python was used for figure generation. Only 137 (32.2%) of the 426 studies analyzed reported the race of participants. Among those studies, we found that the mean participation rate of White participants was significantly higher (82.65%; p < .001). We found a decrease in African American participants and an increase in Asian participants over time. When looking at sex, we found that although the rate of male participation (69.02%) was significantly higher than that of female participation (30.98%), female participation has improved with time at a rate of 0.65% per year.ConclusionWe found that the reporting and participation of minority races continue to lag that of other demographic factors like sex in phase III clinical trials in lung cancer. Based on our analysis, we note a decline in participation of African Americans in lung cancer phase III clinical trials despite the rising incidence of lung cancer.
Compulsory versus voluntary extensive reading: Investigating English learners' perceptions, proficiency and school banding
Authors: Tsang Art , Fung Daniel 
Published: July 2023

AbstractReading is a core element in language education. Despite extensive research in second/foreign language (L2/FL) reading, relatively little is known about the differences between two common practices: Compulsory reading (i.e. reading assigned by teachers) and voluntary reading (i.e. self‐initiated reading). This article reports two related quantitative studies (n = 124; n = 498) investigating learners' out‐of‐class compulsory and voluntary English‐as‐a‐foreign‐language (EFL) story reading frequencies in Hong Kong. Learners' perceptions, EFL proficiency and school banding were analysed in relation to reading frequencies. It was found that the frequencies of engaging in both kinds of reading were very low. Reading frequencies and favourability towards story reading were found to be mildly to moderately correlated with proficiency. Among these variables, however, only voluntary reading significantly predicted proficiency. Students who were academically more competent showed greater favourability while those in the middle school banding reported a higher frequency of reading. The findings are discussed and implications are drawn.
The transcription factor ATF2 promotes gastric cancer progression by activating the METTL3/cyclin D1 pathway
Authors: Meng Hong , Li Jing , Sun Huapeng , Lin Yanxin , Xu Haisheng , Zhang Na 
Published: July 2023

AbstractGlobally, gastric cancer (GC) is a major cause of cancer death. This study is aimed at investigating the biological functions of activating transcription factor 2 (ATF2) and the underlying mechanism in GC. In the present work, GEPIA, UALCAN, Human Protein Atlas and StarBase databases were adopted to analyze ATF2 expression characteristics in GC tissues and normal gastric tissues, and its relationships with tumor grade and patients' survival time. Quantitative real‐time polymerase chain reaction (qRT‐PCR) method was employed to examine ATF2 mRNA expression in normal gastric tissues, GC tissues, and GC cell lines. Cell counting kit‐8 (CCK‐8) and EdU assays were utilized for detecting GC cell proliferation. Cell apoptosis was detected by flow cytometry. PROMO database was applied to predict the binding site of ATF2 with the METTL3 promoter region. The binding relationship between ATF2 and the METTL3 promoter region was verified through dual‐luciferase reporter gene assay and chromatin immunoprecipitation‐quantitative PCR (ChIP‐qPCR) assay. Western blot was performed to evaluate the effect of ATF2 on METTL3 expression. METTL3‐related signaling pathways were predicted using Gene Set Enrichment Analysis (GSEA) in the LinkedOmics database. It was found that, ATF2 level was elevated in GC tissues and cell lines in comparison with normal tissues and correlated with short patients' survival time. ATF2 overexpression facilitated GC cell growth and suppressed the apoptosis, whereas ATF2 knockdown suppressed GC cell proliferation and facilitated the apoptosis. ATF2 bound to the METTL3 promoter region, and ATF2 overexpression promoted the transcription of METTL3, and ATF2 knockdown restrained the transcription of METTL3. METTL3 was associated with cell cycle progression, and ATF2 overexpression enhanced cyclin D1 expression, and METTL3 knockdown reduced cyclin D1 expression. In summary, ATF2 facilitates GC cell proliferation and suppresses the apoptosis via activating the METTL3/cyclin D1 signaling pathway, and ATF2 is promising to be an anti‐drug target for GC.
Mapping marine benthic biological traits to facilitate future sustainable development
Authors: Bolam Stefan G. , Cooper Keith , Downie Anna‐Leena 
Published: July 2023

AbstractEscalating societal demands placed on the seabed mean there has never been such a pressing need to align our understanding of the relationship between the physical impact of anthropogenic activities (e.g., installation of wind turbines, demersal fishing) and the structure and function of the seabed assemblages. However, spatial differences in benthic assemblages based on empirical data are currently not adequately incorporated into decision‐making processes regarding future licensable activities or wider marine spatial planning frameworks. This study demonstrates that, through harnessing a Big Data approach, large‐scale, continuous coverage maps revealing differences in biological traits expressions of benthic assemblages can be produced. We present independent maps based on a suite of response traits (depicting differences in responses to natural or anthropogenically induced change) and effects traits (reflecting different functional potential), although maps derived using single traits or combinations of a range of traits are possible. Models predicting variations in response traits expression provide greater confidence than those predicting effects traits. We discuss how such maps may be used to assist in the decision‐making process for the licensing of anthropogenic activities and as part of marine spatial planning approaches. The confidence in such maps to reflect spatial variations in marine benthic trait expression may, in the future, inherently be improved through (1) the inclusion of more empirical macrofaunal assemblage field data; (2) an improved knowledge of marine benthic taxa trait expression; and (3) a greater understanding of the traits responsible for determining a taxon's response to an anthropogenic pressure and a taxon's functional potential.