bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical activity and mental health among patients with atopic dermatitis or chronic spontaneous urticaria: A cross‐sectional study
Authors: Wiis M. A. B. , Heilskov S. , Sørensen J. A. , Egekvist H. , Deleuran M. , Thomsen S. F. , Vestergaard C. 
Published: April 2023

AbstractBackgroundPhysical and mental health are cogently enhanced through exercise. Atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) are two common inflammatory skin diseases greatly impacting lives of affected patients. Yet, little is known about physical activity and its implications among patients with these diseases.ObjectivesTo investigate physical exercise among patients with AD and CSU, exacerbation of the diseases through exercise, and associations with mental health, life quality measures, and disease severity.MethodsWe performed a cross‐sectional questionnaire study in Denmark on adult AD and CSU patients from two university hospitals and two private dermatology clinics. Included patient‐reported outcome measures (PROMs) were Physical Activity Scale 2 (PAS 2), Dermatology Life Quality Index (DLQI), 9‐item Patient Health Questionnaire (PHQ‐9), 7‐item Generalised Anxiety Disorder (GAD‐7), Insomnia Severity Index (ISI), Work Productivity and Activity Impairment Questionnaire: General Health (WPAI:GH), Urticaria Control Test (UCT), Urticaria Activity Score over 7 days (UAS7), and Patient‐Oriented Eczema Measure (POEM). AD severity was measured with Eczema Area and Severity Index (EASI). Data were non‐normally distributed and analysed with non‐parametric statistics. REDCap and Stata for Macintosh (Apple Inc., USA) were used for management and analysis of data.ResultsIn the AD cohort, any amount of exercise was associated with less symptoms of depression (p < 0.001), anxiety (p = 0.043), and insomnia (p < 0.001). Exacerbation of AD through exercise did not affect PROMs. Exercising CSU patients did not differ concerning any PROMs. Concurrent cholinergic urticaria (CholU) was associated with more symptoms of depression (p = 0.006) and anxiety (p = 0.035) and daily activity impairment (p = 0.015).ConclusionsExercise was associated with improved life quality measures among AD patients but not among CSU patients. Exacerbation of skin disease through exercise did not affect AD patients but was associated with impairment of mental health among CSU patients.
The lncRNA HOTAIR attenuates pyroptosis of diabetic cardiomyocytes by recruiting FUS to regulate SIRT3 expression
Authors: Xiong Jing , Zhou Qing 
Published: April 2023

AbstractDiabetic cardiomyopathy (DCM) is a serious cardiovascular complication of diabetes that severely affects the quality of life of diabetic patients. Long noncoding RNAs (lncRNAs) play important roles in the pathogenesis of DCM. However, the role of the lncRNA homeobox transcript antisense RNA (HOTAIR) in the progression of DCM remains unclear. The present study aimed to investigate the role of HOTAIR in high glucose (HG)‐induced pyroptosis in cardiomyocytes. The expression of the lncRNA HOTAIR, FUS, and SIRT3 in H9C2 cardiomyocytes was detected by RT–qPCR. Western blotting was used to evaluate the expression of FUS and SIRT3 as well as that of pyroptosis‐ and inflammation‐related proteins. RT–qPCR and ELISA were used to determine the expression and secretion of IL‐1β and IL‐18. RNA pulldown and RIP experiments were used to validate the binding relationship among HOTAIR, FUS, and SIRT3. Flow cytometry was performed to detect pyroptosis. HG induced pyroptosis and elevated the expression of proteins associated with pyroptosis and inflammation (NLRP3, GSDMD‐N, cleaved caspase‐1, IL‐1β, and IL‐18) in cardiomyocytes. HOTAIR and SIRT3 levels were decreased in HG‐exposed H9C2 cells. Additionally, overexpression of HOTAIR inhibited the HG‐induced pyroptosis and inflammatory response in cardiomyocytes. HOTAIR upregulated SIRT3 expression in H9C2 cells by targeting FUS. Moreover, SIRT3 upregulation suppressed HG‐mediated pyroptosis of cardiomyocytes. Notably, SIRT3 depletion reversed the inhibitory effect of HOTAIR on HG‐triggered pyroptosis in cardiomyocytes. Our research indicates that HOTAIR alleviates pyroptosis in diabetic cardiomyocytes through the FUS/SIRT3 axis, providing a potential marker for the diagnosis and treatment of DCM.
High Thermal Conductivity Polymer Composites Fabrication through Conventional and 3D Printing Processes: State‐of‐the‐Art and Future Trends
Authors: Vijaybabu T. R. , Ramesh T. , Pandipati Suman , Mishra Sujit , Sridevi G , Raja C Pradeep , Mensah Rhoda Afriyie , Das Oisik , Misra Manjusri , Mohanty Amar , NB Karthik Babu 
Published: April 2023

AbstractThe lifespan and the performance of flexible electronic devices and components are affected by the large accumulation of heat, and this problem must be addressed by thermally conductive polymer composite films. Therefore, the need for the development of high thermal conductivity nanocomposites has a strong role in various applications. In this article, the effect of different particle reinforcements such as single and hybrid form, coated and uncoated particles, and chemically treated particles on the thermal conductivity of various polymers are reviewed and the mechanism behind the improvement of the required properties are discussed. Furthermore, the role of manufacturing processes such as injection molding, compression molding, and 3D printing techniques in the production of high thermal conductivity polymer composites is detailed. Finally, the potential for future research is discussed, which can help researchers to work on the thermal properties enhancement for polymeric materials.
Ti3SiC2 MAX phase for generating mode‐locked pulses in 1.5 µm wavelength region
Authors: Sahib Muhammad A. A. B , Zakaria Rozalina , Zulkipli Nur Farhanah , Rosol Ahmad H. A. , Yasin Moh , Harun Sulaiman W. 
Published: April 2023

AbstractThis letter demonstrates the application of MAX phase material as saturable absorber (SA) for mode‐locking in Erbium‐doped fiber laser (EDFL). Here, we use titanium silicon carbide (Ti3SiC2) compound to make thin film in polyvinyl alcohol host polymer. The fabricated composite film exhibits a saturable absorption of 51% and it produces mode‐locked pulses at 1559 nm in an extended 106 m long EDFL's cavity. The EDFL generates ultrashort pulses with repetition frequency of 1.88 MHz and pulse width of 3.03 ps when the pump is adjusted within 123.7–181.1 mW. At 181.1 mW, the laser achieves the pulse energy of 6.0 nJ and the peak power of 2.0 kW. Overall, the Ti3SiC2 SA establishes a compact and straightforward approach for mode‐locking.
Dynamic analysis of an infinite beam resting on layered transversely isotropic saturated media subjected to moving harmonic loads
Authors: Ai Zhi Yong , Wang Xiao Ming , Ye Zi , Yang Jun Jie 
Published: April 2023

AbstractThis paper investigates the dynamic behavior of an infinite beam on layered transversely isotropic (TI) poroelastic media due to moving harmonic loads. Based on the Euler‒Bernoulli beam theory and Biot theory, the governing equations of the beam and the layered TI poroelastic media are established. By introducing the compatibility conditions at the beam‐subgrade interface, the equivalent stiffness of the layered TI saturated media is derived via the extended precise integration method (PIM) in the wavenumber domain. By means of the inverse Fourier transform algorithm, the physical solutions for the beam‐saturated soil system are obtained after introducing the equivalent stiffness. Then, the accuracy of the proposed method is verified. Several numerical examples are presented to discuss the influences of the moving speed, beam bending rigidity, stratification, and soil anisotropy on the dynamic behavior of beams.
A novel three sub‐step explicit time integration method for wave propagation and dynamic problems
Authors: Wen Weibin , Wu Lang , Liu Tianhao , Deng Shanyao , Duan Shengyu 
Published: April 2023

AbstractA novel explicit time integration method is formulated with sub‐step strategy and Cubic B‐spline interpolation method. Theoretical and numerical analysis are conducted to obtain optimized algorithm properties including algorithm accuracy, spectral stability and numerical dissipation/dispersion. A demonstrative dispersion analysis for wave propagation is presented to acquire optimal algorithm parameter value for finite element analysis of wave propagation problems. Numerical tests demonstrate that new method show desirable algorithm accuracy and convergence for dynamic problems. Especially, for highly nonlinear problems, the new method can provide very accurate and stable solutions.
Relationship between moral sensitivity of nurses and quality of nursing care for patients with COVID‐19
Authors: Darzi‐Ramandi Mahdi , Sadeghi Amir , Tapak Leili , Purfarzad Zahra 
Published: April 2023

AbstractAimThis study aimed to: (1) assess the level of moral sensitivity of nurses and the quality of nursing care for patients with COVID‐19 in Iran; and (2) identify the relationship between the moral sensitivity of nurses and the quality of nursing care for patients with COVID‐19 in Iran.DesignThis study was designed as a descriptive, cross‐sectional, and correlational research.MethodA total of 211 nurses working in four hospitals affiliated with the Hamadan University of Medical Sciences in Iran from December 2021 to April 2022 were selected via the stratified proportional random sampling method. Demographic information, a moral sensitivity questionnaire, and the Good Nursing Care Scale were used for data collection. The data were analysed by SPSS 24 based on descriptive and inferential statistics (Pearson correlation coefficient and multiple regression).ResultsResults revealed that 188 of the nurses (89.1%) had a moderate level of moral sensitivity. Furthermore, 160 of the participants (75.8%) reported a relatively low level of the quality of nursing care. The results of the Pearson correlation coefficient test indicated that there was an inverse and significant relationship between the moral sensitivity of nurses and the quality of nursing care (r = −0.528, p < 0.001). The results of multiple regression indicated that the model of moral sensitivity components explained 27.9% of the variance in the quality of nursing care. The components of moral sensitivity, including relation (β = −0.246, p < 0.001), meaning (β = −0.188, p = 0.003), conflict (β = −0.170, p = 0.008), benevolence (β = −0.153, p = 0.012), and rules (β = −0.144, p = 0.019) had inverse and significant effects on the quality of nursing care.ConclusionSince higher mean scores of moral sensitivity reflect lower moral sensitivity, it can be stated that with the increase in moral sensitivity of nurses, the quality of nursing care for patients with COVID‐19 grows.
Focal versus craniospinal radiation for disseminated atypical teratoid/rhabdoid tumor following favorable response to systemic therapy
Authors: Aridgides Paul D. , Mahajan Anita , Eaton Bree , Wang Dongliang , Timmerman Beate , Früwald Michael C. , Nemes Karolina , Deck Jared , Yamasaki Kai , Von Hoff Katja , Lafay‐Cousin Lucie , Reddy Alyssa , Lo Andrea C. 
Published: April 2023

AbstractPurposeRadiotherapy (RT) is associated with improved survival in atypical teratoid/rhabdoid tumor (ATRT); however, optimal RT delivery is unknown. A meta‐analysis was conducted for disseminated (M+) ATRT receiving focal or craniospinal radiation (CSI).MethodsAfter abstract screening, 25 studies (1995–2020) contained necessary patient, disease, and radiation treatment information (N = 96). All abstract, full text, and data capture were independently double‐reviewed. The corresponding author was contacted for cases of insufficient information. Response to pre‐radiation chemotherapy (N = 57) was categorized as complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD). Univariate and multivariate statistics were performed to investigate survival correlation. Patients with M4 disease were excluded.ResultsThe 2‐ and 4‐year overall survival (OS) was 63.8% and 45.7%, respectively, with a median follow‐up of 2 years (range 0.3–13.5). The median age was 2 years (range 0.2–19.5), and 96% received chemotherapy. On univariate analysis, gross total resection (GTR, p = .0007), pre‐radiation chemotherapy response (p < .001), and high‐dose chemotherapy with stem cell recuse (HDSCT, p = .002) correlated with survival. On multivariate analysis, pre‐radiation chemotherapy response (p = .02) and GTR (p = .012) retained survival significance as compared to a trend for HDSCT (p = .072). Comparisons of focal RT (vs. CSI) and greater than or equal to 5400 cGy primary dose were nonsignificant. Following CR or PR, a statistical trend favored focal radiation (p = .089) over CSI.ConclusionChemotherapy response prior to RT and GTR correlated with improved survival on multivariate analysis for ATRT M+ receiving RT. No benefit was observed for CSI compared to focal RT among all patients and following favorable chemotherapy response, inviting further study of focal RT for ATRT M+.
Vincristine/irinotecan/temsirolimus upfront window treatment of high‐risk hepatoblastoma: A report from the Children's Oncology Group AHEP0731 Study Committee
Authors: Thompson Patrick A. , Malogolowkin Marcio H. , Furman Wayne L. , Piao Jin , Krailo Mark D. , Chung Nadia , Brock Lindsay , Towbin Alexander J. , McCarville Elizabeth B. , Finegold Milton J. , Ranganathan Sarangarajan , Dunn Stephen P. , Langham Max R. , McGahren Eugene D. , Tiao Gregory M. , Weldon Christopher B. , O'Neill Allison F. , Rodriguez‐Galindo Carlos , Meyers Rebecka L. , Katzenstein Howard M. 
Published: April 2023

AbstractBackgroundSurvival for children with metastatic hepatoblastoma (HB) remains suboptimal. We report the response rate and outcome of two courses of vincristine/irinotecan/temsirolimus (VIT) in children with high‐risk (HR)/metastatic HB.ProceduresPatients with newly diagnosed HB received HR window chemotherapy if they had metastatic disease or a serum alpha‐fetoprotein (AFP) level less than 100 ng/mL. Patients received vincristine (days 1 and 8), irinotecan (days 1–5), and temsirolimus (days 1 and 8). Cycles were repeated every 21 days. Responders had either a 30% decrease using RECIST (Response Evaluation Criteria in Solid Tumors) criteria OR a 90% (>1 log10 decline) AFP decline after two cycles. Responders received two additional cycles of VIT intermixed with six cycles of cisplatin/doxorubicin/5‐fluorouracil/vincristine (C5VD). Nonresponders received six cycles of C5VD alone.ResultsThirty‐six eligible patients enrolled on study. The median age at enrollment was 27 months (range: 7–170). Seventeen of 36 patients were responders (RECIST and AFP = 3, RECIST only = 4, AFP only = 10). The median AFP at diagnosis was 222,648 ng/mL and the median AFP following two VIT cycles was 19,262 ng/mL. Three‐year event‐free survival was 47% (95% confidence interval [CI]: 30%–62%), while overall survival was 67% (95% CI: 49%–80%).ConclusionVIT did not achieve the study efficacy endpoint. Temsirolimus does not improve the response rate seen in patients treated with vincristine and irinotecan (VI) alone as part of the initial treatment regimen explored in this study. Additionally, AFP response may be a more sensitive predictor of disease response than RECIST in HB.
Enhanced electrical and electromagnetic interference shielding performance of immiscible poly(vinylidene chloride)/poly(lactic acid)/multi‐walled carbon nanotube composites via constructing filler‐wrapped porous structure
Authors: Li Yilong , Nie Cong , Song Danyang , Liu Yujie , Jia Yunchao , Zheng Hongjuan 
Published: April 2023

AbstractHerein, immiscible poly(vinylidene fluoride)/poly(lactic acid) (PVDF/PLA) blends filled with multi‐walled carbon nanotubes (MWCNT) were fabricated by a facile solution flocculation method. A co‐continuous structure was formed at the blend ratio of 50v/50v. By extracting PLA, MWCNTs were found wrapped on the surface of porous PVDF. The electrical percolation threshold of porous composites is 0.25 wt.%, which is much lower than compact composites (2 wt.%). By comparing the electromagnetic interference shielding effectiveness (EMI SE) between compact and porous composites, the EMI SE of compact composites containing 15 wt.% MWCNT is ca. 30 dB, whereas 60 dB for the porous composites at the same filler loading. The enhanced shielding performance is derived from the porous structure and densely packed MWCNT on the PVDF surface that facilitates the multiple reflections of electromagnetic waves. This work provides a new thought in fabricating high performance EMI material by effectively tuning filler distribution in polymer blends.
Electronic tissue technologies for seamless biointerfaces
Authors: Minev Ivan R. 
Published: April 2023

AbstractBioelectronic interfaces establish a communication channel between a living system and an electrical machine. The first examples emerged in the 18th century when batteries were used to “galvanize” muscles and nerves. Today bioelectronic interfaces underpin key medical technologies such as the cardiac pacemaker and emerging ones such as neuroprostheses and brain‐machine interfaces. Despite compelling applications in living systems, bioelectronic interfaces employ materials from microelectronics that are rigid, impermeable to water and bioinert. In contrast, electrical phenomena in soft tissues such as muscle and nerve are mediated by ions and molecules solvated in water. This disparity leads to missed opportunities for achieving seamless interfaces and communication that extends beyond electrical stimulation and recording. In this perspective, I discuss opportunities presented by hydrogel materials for building bioelectronic interfaces. This will require new types of hydrogels that support both ionic and electronic conductivity combined with key functions of the extracellular matrix.
Optically Controlled Development of a Waveguide from a Reservoir of Microparticles
Authors: Karpinski Pawel , Sznitko Lech , Wisniewska‐Belej Monika , Miniewicz Andrzej , Antosiewicz Tomasz J. 
Published: April 2023

AbstractLight can be guided without diffraction in prefabricated structures: optical fibers and waveguides or in actively created spatial solitons in optically nonlinear media. Here, an approach in which a self‐stabilized optical waveguide develops from a reservoir of building blocks—spherical polymer microparticles (MPs)—and is pushed through an optically passive medium—water—is presented. The optical waveguide, formed by a chain of these microparticles and one microsphere wide, is self‐stabilized and propelled by the guided light, while its geometrical and dynamical properties depend on the diameter‐to‐wavelength ratio. The smallest investigated particles, 500 nm in diameter, form single‐mode waveguides up to tens of micrometers long, with the length limited only by optical losses. In contrast, waveguides constructed of larger MPs, 1 and 2.5 µm in diameter, are limited in length to only a few particles due to interference of different modes and beating of light intensity.
Low Dose of Ti3C2 MXene Quantum Dots Mitigate SARS‐CoV‐2 Infection
Authors: Yilmazer Açelya , Alagarsamy Keshav Narayan , Gokce Cemile , Summak Gokce Yagmur , Rafieerad Alireza , Bayrakdar Fatma , Ozturk Berfin Ilayda , Aktuna Suleyman , Delogu Lucia Gemma , Unal Mehmet Altay , Dhingra Sanjiv 
Published: April 2023

AbstractMXene QDs (MQDs) have been effectively used in several fields of biomedical research. Considering the role of hyperactivation of immune system in infectious diseases, especially in COVID‐19, MQDs stand as a potential candidate as a nanotherapeutic against viral infections. However, the efficacy of MQDs against SARS‐CoV‐2 infection has not been tested yet. In this study, Ti3C2 MQDs are synthesized and their potential in mitigating SARS‐CoV‐2 infection is investigated. Physicochemical characterization suggests that MQDs are enriched with abundance of bioactive functional groups such as oxygen, hydrogen, fluorine, and chlorine groups as well as surface titanium oxides. The efficacy of MQDs is tested in VeroE6 cells infected with SARS‐CoV‐2. These data demonstrate that the treatment with MQDs is able to mitigate multiplication of virus particles, only at very low doses such as 0,15 µg mL−1. Furthermore, to understand the mechanisms of MQD‐mediated anti‐COVID properties, global proteomics analysis are performed and determined differentially expressed proteins between MQD‐treated and untreated cells. Data reveal that MQDs interfere with the viral life cycle through different mechanisms including the Ca2+ signaling pathway, IFN‐α response, virus internalization, replication, and translation. These findings suggest that MQDs can be employed to develop future immunoengineering‐based nanotherapeutics strategies against SARS‐CoV‐2 and other viral infections.
Development of Spectral Imaging Cytometry
Authors: Vorobjev Ivan A. , Kussanova Aigul , Barteneva Natasha S. 
Published: April 2023

AbstractSpectral flow cytometry is a new technology that enables measurements of fluorescent spectra and light scattering properties in diverse cellular populations with high precision. Modern instruments allow simultaneous determination of up to 40+ fluorescent dyes with heavily overlapping emission spectra, discrimination of autofluorescent signals in the stained specimens, and detailed analysis of diverse autofluorescence of different cells—from mammalian to chlorophyll-containing cells like cyanobacteria. In this paper, we review the history, compare modern conventional and spectral flow cytometers, and discuss several applications of spectral flow cytometry.
Acacia-Bonsai: A Modern Implementation of Downset-Based LTL Realizability
Authors: Cadilhac Michaël , Pérez Guillermo A. 
Published: April 2023

AbstractWe describe our implementation of downset-manipulating algorithms used to solve the realizability problem for linear temporal logic (LTL). These algorithms were introduced by Filiot et al. in the 2010s and implemented in the tools Acacia and Acacia+ in C and Python. We identify degrees of freedom in the original algorithms and provide a complete rewriting of Acacia in C++20 articulated around genericity and leveraging modern techniques for better performance. These techniques include compile-time specialization of the algorithms, the use of SIMD registers to store vectors, and several preprocessing steps, some relying on efficient Binary Decision Diagram (BDD) libraries. We also explore different data structures to store downsets. The resulting tool is competitive against comparable modern tools.
Probabilistic Program Verification via Inductive Synthesis of Inductive Invariants
Authors: Batz Kevin , Chen Mingshuai , Junges Sebastian , Kaminski Benjamin Lucien , Katoen Joost-Pieter , Matheja Christoph 
Published: April 2023

AbstractEssential tasks for the verification of probabilistic programs include bounding expected outcomes and proving termination in finite expected runtime. We contribute a simple yet effective inductive synthesis approach for proving such quantitative reachability properties by generating inductive invariants on source-code level. Our implementation shows promise: It finds invariants for (in)finite-state programs, can beat state-of-the-art probabilistic model checkers, and is competitive with modern tools dedicated to invariant synthesis and expected runtime reasoning.