bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanosuspension: A Formulation Technology for Tackling the Poor Aqueous Solubility and Bioavailability of Poorly Soluble Drugs
Authors: Elsebay Mohamed T. , Eissa Noura G. , Balata Gehan F. , Kamal Mohammad Amjad , Elnahas Hanan M. 
Published: September 2023

Abstract:The poor water solubility of numerous novel drug candidates presents significant challenges, particularly in terms of oral administration. This limitation can result in various undesirable clinical implications, such as inter-patient variability, poor bioavailability, difficulties in achieving a safe therapeutic index, increased costs, and potential risks of toxicity or inefficacy. Biopharmaceutics Classification System (BCS) class II drugs face particular hurdles due to their limited solubility in the aqueous media of the gastrointestinal tract. In such cases, parenteral administration is often employed as an alternative strategy. To address these challenges, nanosuspension techniques offer a promising solution for enhancing drug solubility and overcoming oral delivery obstacles. This technique has the potential to bridge the gap between drug discovery and preclinical use by resolving problematic solubility. This literature review has delved into contemporary nanosuspension preparation technologies and the incorporation of stabilizing ingredients within the formulation. Furthermore, the manuscript explores nanosuspension strategies for both oral and parenteral/other delivery routes, and separate discussions have been presented to establish a suitable flow that addresses the challenges and strategies relevant to each administration method.
Covalent Binding of Fullerene С60 to Strained Polycyclic Hydrocarbons: Promising
Organic Field-effect Transistors Based on them
Authors: Akhmetov Arslan R. , Aminov Rishat I. , Sadretdinov Zarema R. , Salikhov Renat B. , Mullagaliev Ilnur N. , Salikhov Timur R. 
Published: September 2023

Abstract:
Hybrid molecules based on fullerene С60 and strained polycyclic hydrocarbons were synthesized for the
first time using the Bingel–Hirsch reaction. The films of fullerene derivatives were deposited by centrifugation. The
synthesized hybrid fullerene С60derivatives containing one strained polycyclic hydrocarbon moiety showed better
charge carrier mobility than the fullerene derivatives containing two polycyclic hydrocarbon moieties. Apart from
current–voltage characteristics, the morphology of the prepared hybrid compounds was studied. The best current–
voltage characteristics were found for films with lower roughness. The fullerene С60 adducts containing strained
polycyclic hydrocarbon moieties were used to fabricate organic field effect transistors (OFETs) with high-quality
films; owing to this, the manufacturing process is compatible with modern printed organic electronics.
Advancements in Autologous Stem Cell Transplantation for Parkinson’s Disease
Authors: Shi Jia-Xin , Zhang Ke-Zhong 
Published: September 2023

:
Parkinson's disease (PD) is a progressive neurodegenerative disease marked by comparatively
focal dopaminergic neuron degeneration in the substantia nigra of the midbrain and dopamine loss in the
striatum, which causes motor and non-motor symptoms. Currently, pharmacological therapy and deep
brain stimulation(DBS) are the primary treatment modalities for PD in clinical practice. While these approaches
offer temporary symptom control, they do not address the underlying neurodegenerative process,
and complications often arise. Stem cell replacement therapy is anticipated to prevent further progression
of the disease due to its regenerative capacity, and considering the cost of immunosuppression
and the potential immune dysfunctions, autologous stem cell transplantation holds promise as a significant
method against allogeneic one to treat Parkinson's disease. In this review, the safety concerns surrounding
tumorigenicity and complications associated with transplantation are discussed, along with
methods utilized to evaluate the efficacy of such procedures. Subsequently, we summarize the preclinical
and clinical studies involving autologous stem cell transplantation for PD, and finally talk about the benefits
of autologous stem cell transplantation against allogeneic transplants.
An Update on Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria
Authors: Miniello Andrea , Casella Rossella , Loverre Teresa , Aloia Dario , Di Bona Danilo , Nettis Eustachio 
Published: September 2023

Background:
Hypersensitivity reactions to non-steroidal anti-inflammatory drugs
(HR-NSAIDs) are common adverse events related to the widespread use of over-the-counter
NSAIDs for the treatment of a variety of inflammatory conditions. Urticaria is the most commonly
reported immediate cutaneous clinical sign of HR-NSAIDs, but it can be a manifestation
of pathophysiologically different clinical entities that require different therapeutic strategies. The
aim of this study is to ease the identification of the correct phenotype of HR-NSAIDs in patients
reporting urticaria associated with the intake of NSAIDs and provide updated information about
their diagnosis and management.

Methods:
The study is a narrative review conducted by collecting the most relevant and up-todate
data related to the classification, pathophysiology, severity, and prognosis of NSAID hypersensitivity
reactions. PubMed and Embase scientific databases were used as search engines to select
relevant articles.

Results:
Patients developing HR-NSAIDs can be divided into two categories: selective responders
(SR), who develop reactions after the administration of a single specific NSAID due to an
underlying IgE or T-cell mediated hypersensitivity mechanism, or cross-intolerant (CI), who develop
reactions to more than one chemically unrelated NSAIDs due to abnormalities in the biochemical
pathways related with prostaglandin metabolism, independently from an underlying
immunological mechanism. Five major different categories of HR-NSAIDs have been identified:
NSAIDs-exacerbated cutaneous disease (NECD), NSAIDs-induced urticaria/angioedema
with/without respiratory and systemic symptoms of anaphylaxis (NIUAA), and NSAIDsexacerbated
respiratory disease (NERD), which are developed by CI patients, and single
NSAIDs-induced urticaria, angioedema and/ or anaphylaxis (SNIUAA) and single NSAIDsinduced
delayed hypersensitivity reactions (SNIDHR), which are developed by CI patients. In vivo
and in vitro diagnostic tests have rarely been shown to be reliable in all these entities and
therefore are not routinely used in clinical practice. The management in SR patients consists of
strict avoidance of the culprit drug, while for cross-intolerance reactions oral tolerance tests with
safe alternative drugs (e.g. weak COX-1 inhibitors or selective COX-2 inhibitors) can be performed.

Conclusion:
HR-NSAIDs are being observed with increasing frequency, however, the pathogenesis
behind some NSAIDS-associated clinical entities is still unclear. Diagnosis is mostly
based on a thorough clinical history and confirmed by a drug challenge test. Clinical
management is based on strict avoidance and use of alternative tolerated medications. Overall, all
therapeutic decisions depend on the correct identification of the type of reaction the patient
experienced.
Knowledge Mapping of Human Activity Recognition Techniques for
Assistive Living
Authors: Agarwal Preeti , Alam Mansaf 
Published: September 2023

Purpose:
Human Activity Recognition (HAR) is a subject of research that identifies an individual’s
activities for assistive living. The proliferation of ICT and sensor technology prompted
HAR to flourish beyond unfathomable levels, having immense human-centric applications. The development
of accurate HAR systems involves complex statistical and computational tasks from signal
acquisition to activity classification. This research aims to conduct a systematic review of recent techniques
proposed for each stage of HAR application development.

Methodology:
The review is conducted following Kitchenham principles, using Scopus and Web of
Science databases. Firstly, research questions were formulated, followed by the search strategy definition.
Based on assessment criteria, 193 papers are shortlisted and thoroughly analyzed to extract research-
related information.

Results:
The techniques identified in 193 articles are comprehensively mapped from four aspects: data
acquisition, data preprocessing and feature engineering, learning algorithm, and evaluation. Each
technique is examined for its strengths and limitations to assist application developers in selecting the
best one for their needs. The prevailing challenges and upcoming research opportunities are thoroughly
explored.

Conclusion:
The ever-expanding literature in the field necessitated an update to the status of HAR literature.
Compared to other reviews that focused on specific methods, fields of application, and
datatypes, to the best of our understanding, this is the first evaluation of its kind that provides a broader
mapping of HAR approaches. The findings of this analysis will provide researchers and newcomers
in the field an up-to-date and holistic view of the complete body of work in this area.
Synthesis and Characterisation of Porous Carbide-derived Carbon from SiC in Molten Salt
Authors: Zheng Kai , Shi Cuilian , Li Jierui , Su Xiangdong 
Published: September 2023

Aims:
In this paper, we aimed to prepare SiC-CDC with porous structure
from SiC precursor by using simple molten salt electrochemical etching method at 900
ºC in argon at an applied constant voltage of 3.0 V.

Background:
Nanoporous materials include carbon materials, silica or alumina, gel,
and zeolite, which have been known since ancient times. Among all these materials,
carbon materials are particularly outstanding. In recent years, carbide-derived carbon
(CDC), a type of unconventional carbon material produced by selectively extracting
metal elements from the lattice of carbides, has attracted increasing attention from researchers.
Many different methods have now been proposed to prepare CDC, among
these methods, currently the preparation of mesoporous carbide-derived carbon (CDCs)
materials mainly relies on chlorination. The main problems with chlorination are the
corrosion of chlorine gas and the treatment of secondary products (MClx). Therefore,
the search for environmentally friendly strategies for the production of CDC is still ongoing.

Objective:
This article proves that we can successfully prepare SiC-CDC with porous
structure from SiC precursor by using simple molten salt electrochemical etching method
at 900ºC in argon at an applied constant voltage of 3.0 V.

Methods:
The SiC-CDC with porous structure has been prepared from SiC precursor by
using simple molten salt electrochemical etching method at 900ºC in argon at an applied
constant voltage of 3.0 V.

Results:
The results show that the nanoporous SiC-CDC was successfully synthesized
from the silicon carbide microspheres powder via by electrolysis in molten CaCl2 at 3.0
V, 900°C for 15 h.

Conclusions:
The nanoporous SiC-CDC was successfully synthesized from the silicon
carbide microspheres powder via by electrolysis in molten CaCl2 at 3.0 V, 900°C for 15
h and their microstructure, specifc surface area, and pore size were analyzed. The SiCCDC
obtained in this experiment mainly consisted of amorphous carbon and maintained
the shape of SiC particles. The SiC-CDC is a mixture of amorphous carbon and ordered
graphite phase with a highly degree of graphitization. The SiC-CDC displays a BET
specific surface area of 561.39 m2/g and a total pore volume of 0.39 cm3/g. This method
to produce SiC-CDC is very attractive because it will not only pave a new way for the
preparation of SiC-CDC but also for mass production of high-quality carbon material.
Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome
Authors: Bilchenko A.O. , Kopytsya M.P. , Petyunina O.V. , Vishnevskaya I.R. , Rodionova Iu.V. 
Published: September 2023

Background. Coronary artery disease (CAD) persistently remains the leading cause of mortality globally. Given the severity and impact of this condition, researchers have been meticulously studying the pathogenesis of athe-rosclerosis, a principal cause behind CAD. The pathogenesis stages are complex and multifaceted, including factors such as lipid accumulation, inflammation, and plaque formation. A particular area of active exploration pertains to the influence and role of different biomarkers, including matrix metalloproteinase 9 (MMP-9) and myeloperoxidase (MPO), on these processes. These biomarkers have been associated with the progression and destabilization of athe-rosclerotic plaques, which are central to CAD. However, the use of these biomarkers in the context of comorbidities, such as chronic kidney disease, remains an open area of research, especially in patients after myocardial infarction. Materials and methods. In our study, 96 patients who had acute coronary syndrome and subsequently undergone percutaneous coronary intervention were enrolled. They were stratified into groups (A and B) based on respective glomerular filtration rates. The primary endpoint of the study was all-cause mortality and major adverse cardiovascular and cerebrovascular events. Results. Our analysis revealed that serum levels of MPO in group B were insignificantly higher than those in group A. Conversely, the area under the receiver operating characteristic (ROC) curve for MMP-9 in group A exhibited a significant difference, standing at 0.8 (95% confidence interval 0.609–0.991; p = 0.039). However, the ROC curve for MPO did not yield a significant result in any group. A combined ROC curve was also generated, with the area under this curve showing a significantly higher value of 0.890 (95% confidence interval 0.805–0.975; p < 0.001). Conclusions. We found that plasma levels of the above-mentioned biomarkers do not seem to influence a decrease in glomerular filtration rate. Nonetheless, MMP-9 levels offered significant prognostic information regarding predicted outcomes.
Increasing the Health-Related Quality of Life in Children with Congenital Rubella Syndrome: A Mixed-methods Study
Authors: Herini Elisabeth Siti , Triono Agung , Iskandar Kristy , Prasetyo Ashadi , Nuady Albaaza , Hadiyanto Marissa Leviani , Diantika Kania , Wijayanti Veronica Wulan , Pramastuti Avianti 
Published: September 2023

Background: Rubella infection during the first trimester of pregnancy is a significant cause of fetal malformation syndrome, known as Congenital Rubella Syndrome (CRS). The most prevalent abnormalities associated with CRS are hearing loss, vision impairment (primarily congenital cataracts), congenital heart disease, and global developmental delay affecting the children's quality of life (QoL). A Community Engagement Program was arranged collaboratively to increase the QoL of children with CRS and enhance parents' skills and knowledge to better care for their children with CRS.Methods: A mixed-method descriptive study was conducted to assess the QoL improvement in children with CRS and to determine parents' knowledge about CRS. Children's QoL data were obtained using the Pediatric Quality of Life Inventory (PedsQL)TM 4.0 Generic Core Scales and analyzed with paired T-tests. A survey and focus group discussion (FGD) were used to gather parents' knowledge about CRS.Results: We involved ten members willing to participate voluntarily in the PedsQL assessment and FGD. The result was an increase in patients' QoL in the Physical Function domain that was statistically significant: pre-test and post-test physical health summary (490 (±261) vs. 510 (±251); p=0.022), social (322 (±126) vs. 337 (±113); p=0.217), emotional (370 (±105) vs. 397 (±105); p=0.065), and school (342 (±94) vs. 355 (±97); p=0.586). From the survey and the FGD, the parents had diverse experiences and understanding of CRS-supporting examinations and treatments needed. Parents felt the children's growth and development, social and school functions were the common burdens. In order to help CRS prevention, the parents suggested a more comprehensive premarital program and antenatal care.Conclusions: The Community Engagement Program helps to increase the patients’ QoL in the Physical Function domain. Comprehensive multidiscipline management is needed to support children's growth, social function, and educational function. Periodic evaluations are required to monitor the QoL of children with CRS.
Immunization Program Intervention Training in Stunting Prevention Effort in Sampang Regency, Madura Island, East Java
Authors: Artanti Kurnia Dwi , Hargono Arief , Yamani Laura Navika , Fadhilah Farah , Hasan Taufiq Hidayat 
Published: September 2023

Stunting was still a major health problem in Indonesia. Sampang Regency was one of the districts that experienced an increase in the prevalence of Stunting. According to the 2018 Riskesdas data, it shows that one in three babies under two years old (baduta) and babies under five years old (toddlers) in Indonesia are in the stunting category. To prevent stunting, intervention was needed to increase the number of immunization. The aim in this activity was to identify the barrier increasing Universal Coverage Immunization (UCI) to solve immunization problem by Human Centered-Design (HCD) method. The method used is a qualitative method using HCD, which is a method used to explore problems from the community side. This activity was involved by the head of the epidemiology and immunization section, the program holders of the Sampang district health office, coordinating midwives and immunization coordinators at selected health centers regarding immunization program interventions, namely exploring immunization problems from the community. The HCD intervention method has several steps, namely Persona, Journey of Map, Quote, Findings and Suggestions. The results from the intervention was every public health centers known to have a different picture related to portraits of people in the community who are influential in the implementation of the immunization program. This program showed that health was not only the responsibility of government or the health program holders, but everyone. The recommendations from the HCD training at the two public health centers agreed to re-advocate the immunization program to relevant stakeholders.
Analysis of The Physicochemical and Sensory Quality of Adee Cake During Storage
Authors: Sulaiman Ismail , Rohaya Syarifah , Ichsan Muhammad 
Published: September 2023

Abstract: Cake is a wet food product made by baking dough from flour, sugar, eggs, milk, fat, and other additives. Adee cake is one of the typical foods marketed in the Pidie area, which is very famous and becomes one of the foods as souvenirs. The problem faced with this cake is the shelf life and quality of the cake. Therefore, this research was carried out about the physicochemical properties of Adee cake during the storage process and to observe the sensory properties. This study used a completely randomized design (CRD) with a non-factorial pattern, namely storage time consisting of (0, 1, 2, 3, and 4 days) with three repetitions. Further tests of DMRT will follow the analysis of variance ANOVA in this study. The results of the hardness analysis obtained an average of 51.43 gf. The color analysis showed that the average coefficient value was 111 on the top and 252 on the inside showing a very significant difference. Chemical analysis obtained the average, namely, water content 39.30%, ash content 0.79%, fat content 7.94%, protein content 1.82%, crude fiber content 0.70%, and carbohydrates 49.76%, showed a very significant difference (P≤0.01). The organoleptic test analysis (hedonic) obtained the average, namely, color 3.63, texture 3.29, flavor 3.64, taste 3.30, and overall 3.46 showed a very significant difference (P≤0.01).Abstrak: Cake merupakan salah satu produk makanan semi-basah yang dibuat dengan pemanggangan adonan dari tepung, gula, telur, susu, lemak dan bahan tambahan lainnya. Cake adee ini merupakan salah satu makanan khas yang dipasarkan di daearah Pidie, yang sangat terkenal dan menjadi salah satu makanan sebagai oleh-oleh, problem yang dihadapi pada cake ini adalah masa simpan dan kualitas dari kue tersebut, oleh karena itu dilakukan penelitian tentang sifat fisikokimia kue Adee selama proses penyimpanan dan mengamati sifat sensorisnya. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan pola non faktorial yaitu lama penyimpanan yang terdiri dari (0, 1, 2, 3, dan 4 hari) dengan tiga kali pengulangan. Selanjutnya uji DMRT akan mengikuti analisis varians ANOVA pada penelitian ini. Hasil analisis kekerasan diperoleh rata-rata 51,43 gf, hasil analisis warna menunjukkan nilai koefisien rata-rata 111 pada bagian atas dan 252 pada bagian dalam menunjukkan perbedaan yang sangat signifikan. Analisis kimia diperoleh rata-rata kadar air 39,30%, kadar abu 0,79%, kadar lemak 7,94%, kadar protein 1,82%, kadar serat kasar 0,70%, dan karbohidrat 49,76%, menunjukkan perbedaan yang sangat nyata (P≤0,01). Uji organoleptik (hedonik) diperoleh rata-rata yaitu warna 3,63, tekstur 3,29, rasa 3,64, rasa 3,30, dan keseluruhan 3,46 menunjukkan perbedaan yang sangat nyata (P≤0,01).