bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dislexia, estrategias en el aprendizaje
Authors: Moreira- Barre Fresia , Pita-Mantilla Lourdes , Castro-Ponce Nelly , Ascencio-Rodríguez Pierre , Vacacela-Zorrilla5 Marjorie , Pacheco-Almendariz Luis 
Published: May 2023

En esta indagación presentaremos diferentes, tratamientos y diversas propuestas sobre la correlación del trastorno mencionado como dislexia, cabe resaltar que, esta necesidad pedagógica sin asociación a la discapacidad emerge en la infancia, puesto que, se establecen métodos, estructuras y técnicas dinámicas que se desarrollaran de carácter fundamental en la ejecución del aprendizaje. Según la real academia española, define a este trastorno como una “dificultad en el aprendizaje tanto en la lectura como en la escritura. Puesto que, es importante saber que la dislexia no se asocia con la inteligencia, al igual que los otros niños, ellos también son muy inteligentes. Por lo que alrededor del mundo existen personas con problemas de aprendizaje dentro del área de la lengua y literatura, si bien es cierto para muchos estudiantes estos componentes son parte de su diario vivir y la dominan, así mismo habiendo inconvenientes para otros no les agrada la lectura y la escritura, debido a la dificultad y problemas que tienen a la hora de practicarla. Por otro lado, podemos notar el desafío desde la perspectiva de cada docente sobre la diversidad y la inclusión educativa, experiencia, conocimientos, métodos por el déficit y escaso discernimiento a estos diversos temas, la falta de experiencia en preparación de materiales y técnicas didácticas como la planificación, diseños y desarrollos de los currículos aplicados en la práctica.
Unificación de la interacción gravitatoria terrestre con la interacción electromagnética
Authors: González González Pionono 
Published: May 2023

El presente artículo tiene como objetivo unificar la interacción gravitatoria con la interacción electromagnética, tomando como base a la inducción magnética (B) para establecer las demás magnitudes (magnéticas y eléctricas) que rigen nuestro sistema. La tierra es asumida como un elipsoide con base GRS80, tomando latitudes geocéntricas que garanticen que el radio terrestre parta del centro de la tierra y forme ángulo con las coordenadas del punto espacial que se escoja en la superficie, para determinar el efecto de la gravitación y su interacción con el campo magnético. Se presume un dipolo axialmente simétrico alrededor del eje Z coordenado y se aplica la ecuación de la inducción magnética, en función del momento magnético y el ángulo de colatitud geocéntrica, que arroja como resultado la unificación de la fuerza electromagnética con la interacción gravitatoria terrestre, mediante la ecuación formulada como:
[nT]; con k1 = 9,93 .102 [nT.(Kg/N)3/2] (1)
O, en su defecto, por despeje, se demuestra la ecuación deducida de la interacción gravitatoria, en función de la inducción magnética, mediante la ecuación:
[m/s2]; con k2 = 1,01 .10-2 [N/Kg.(nT)2/3] (2)
Diseño e implementación de Software para el programa de fortalecimiento de la Calidad Educativa para reducir errores contables en la coordinación del área de Ingenierías de la Universidad Autónoma de Zacatecas
Authors: Fraire Hernández Miguel Ángel , Flores Chaires Luis Alberto , Pineda Martinez Hugo , Martinez Rodríguez Miguel 
Published: May 2023

El propósito de esta investigación es diseñar e implementar un software el cual sea utilizado por el programa de fortalecimiento de la calidad educativa. Y este sea capaz de reducir errores contables en la Coordinación del Área de Ingenierías de la Universidad Autónoma de Zacatecas Francisco García Salinas. El Software permite mejorar los procesos de validación de compras, pagos y gestión de la calidad tanto en materiales, servicios e infraestructura académica, y de manera simultánea emita reportes tanto académicos como financieros, y de esta manera tener un mejor control interno en movimientos contables del área. Con la implementación del Software se determinará con alta precisión los movimientos académicos, fiscales y contables que requiere el Área de Ingenierías de la UAZ, para transparentar de forma eficaz los Proyectos Federales.
A Measurement of the Kuiper Belt’s Mean Plane From Objects Classified By Machine Learning
Authors: Matheson Ian , Malhotra Renu 
Published: May 2023

Abstract
Mean plane measurements of the Kuiper Belt from observational data are of interest for their potential to test dynamical models of the solar system. Recent measurements have yielded inconsistent results. Here we report a measurement of the Kuiper Belt’s mean plane with a sample size more than twice as large as in previous measurements. The sample of interest is the nonresonant Kuiper Belt objects, which we identify by using machine learning on the observed Kuiper Belt population whose orbits are well determined. We estimate the measurement error with a Monte Carlo procedure. We find that the overall mean plane of the nonresonant Kuiper Belt (semimajor axis range of 35–150 au) and also that of the classical Kuiper Belt (semimajor axis range of 42–48 au) are both close to (within ∼0.°7) but distinguishable from the invariable plane of the solar system to greater than 99.7% confidence. When binning the sample into smaller semimajor axis bins, we find the measured mean plane is mostly consistent with both the invariable plane and the theoretically expected Laplace surface forced by the known planets. Statistically significant discrepancies are found only in the semimajor axis ranges 40.3–42 au and 45–50 au; these ranges are in proximity to the ν
8 secular resonance and Neptune’s 2:1 mean motion resonance where the theory for the Laplace surface is likely to be inaccurate. These results do not support a previously reported anomalous warp at semimajor axes above 50 au.
First record of the predatory stink bug species Picromerus griseus (Dallas) (Hemiptera, Heteroptera, Pentatomidae, Asopinae) in Japan, with an illustrated key to the Japanese species of the genus Picromerus Amyot &amp; Serville
Authors: Souma Jun , Utagawa Akihiro , Ishikawa Tadashi 
Published: May 2023

The predatory stink bug genus Picromerus Amyot & Serville, 1843 (Hemiptera, Heteroptera, Pentatomidae, Asopinae) comprises 11 species found in the Northern Hemisphere. In Japan, two species have been recorded to date. However, an easy-to-understand identification method, such as an illustrated key, is lacking. Currently, Picromerus griseus (Dallas, 1851) has been recorded in Bangladesh, Bhutan, China, Indonesia, Myanmar, Pakistan and Taiwan, but not in Japan.
Picromerus griseus was recorded in Japan for the first time, based on a single individual collected from grasslands around the fields of Ishigaki Island of the Ryukyu Islands, which belong to the Oriental Region. This discovery represents the easternmost record of the species. An illustrated key to the species of Picromerus occurring in Japan is also provided.
Comment la téléconsultation médicale « en autonomie » infléchit-elle les rapports de pouvoir dans la relation médecin-patient ?
Authors: Calheiros Cécilia 
Published: May 2023

Depuis la seconde moitié du 20ème siècle, le système de santé français a connu un certain nombre d’évolutions (politiques budgétaires, remise en cause de l’autorité médicale, plus grande autonomie du patient, etc.) qui ont notamment eu pour conséquences de modifier le cadre d’exercice de la médecine et de la relation médecin-patient. Le recours massif à la téléconsultation depuis 2020 appelle à s’interroger sur la façon dont la mise à distance des corps modifie la relation médecin-patient en reconfigurant les asymétries d’information et en produisant un contexte de confiance « contrainte » dans la parole du patient. Cet article se propose d’analyser un type particulier de téléconsultations, celles ayant lieu en autonomie. Par cette expression nous entendons celles qui se déroulent sur des plateformes privées entre un patient autonome, sans instrument connecté à disposition, et un médecin généraliste exerçant en libéral.
C3/CD11b-Mediated Leishmania major Internalization by Neutrophils Induces Intraphagosomal NOX2-Mediated Respiratory Burst but Fails to Eliminate Parasites and Induces a State of Stalled Apoptosis
Authors: Ranson Adam J , Carneiro Matheus B , Perks Benjamin , Penner Robert , Melo Leon , Canton Johnathan , Egen Jackson , Peters Nathan C 
Published: May 2023

Abstract
Recruited neutrophils are among the first phagocytic cells to interact with the phagosomal pathogen Leishmania following inoculation into the mammalian dermis. Analysis of Leishmania-infected neutrophils has revealed alterations in neutrophil viability, suggesting that the parasite can both induce or inhibit apoptosis. In this study, we demonstrate that entry of Leishmania major into murine neutrophils is dependent on the neutrophil surface receptor CD11b (CR3/Mac-1) and is enhanced by parasite opsonization with C3. Infected neutrophils underwent robust NADPH oxidase isoform 2 (NOX2)–dependent respiratory burst based on detection of reactive oxygen species within the phagolysosome but largely failed to eliminate the metacyclic promastigote life cycle stage of the parasite. Infected neutrophils displayed an “apoptotic” phosphatidylserine (PS)-positive phenotype, which was induced by both live and fixed parasites but not latex beads, suggesting that PS expression was parasite specific but does not require active infection. In addition, neutrophils from parasite/neutrophil coculture had increased viability, decreased caspase 3, 8, and 9 gene expression, and reduced protein levels of both the pro and cleaved forms of the classical apoptosis-inducing executioner caspase, Caspase 3. Our data suggest that CD11b-mediated Leishmania internalization initiates respiratory burst and PS externalization, followed by a reduction in both the production and cleavage of caspase 3, resulting in a phenotypic state of “stalled apoptosis.”
Clinical profile and management with immunosuppressants and biologics in Behcet’s uveitis: A cohort of 25 patients from a tertiary eye care center in South India
Authors: Ramdoss Jeyasooriya , Singh Prerana , Ahmed Arshee S , Biswas Jyotirmay 
Published: May 2023

Purpose:
To report the clinical profile of Behcet’s disease and its management with immunosuppressants and biologics in a cohort of 25 patients from a tertiary eye care center in South India.

Methods:
This was a retrospective, observational study. Records of 45 eyes of 25 patients between January 2016 and December 2021 were retrieved from the hospital database. Complete ophthalmic evaluation and systemic examination by the rheumatologist with appropriate investigations had been done. Results were analyzed using Statistical Package for the Social Sciences (SPSS) software.

Results:
Males (19, 76%) were found to be more affected than females (6, 24%). Mean age of presentation was 27.68 ± 11.08 years. Twenty patients had bilateral involvement (80%), and unilateral involvement was seen in five patients (20%). Seven eyes of four patients (16%) had isolated anterior uveitis, out of which one patient had unilateral and three patients had bilateral involvement. Twenty-six eyes of 16 patients (64%) had posterior uveitis, out of which six patients had unilateral and 10 had bilateral involvement. Twelve eyes of seven patients (28%) had panuveitis, out of which two patients had unilateral and five had bilateral involvement. Hypopyon was seen in five eyes (11.1%) and posterior synechiae in seven eyes (15.55%). Posterior segment findings included vitritis (24.44%), vasculitis (17.78%), retinitis (17.78%), disc hyperemia (11.11%), and disc pallor (8.89%). Steroids alone were given in five patients (20%) and intravenous methylprednisolone (IVMP) was given in four patients (16%). Immunosuppressive agents along with steroids were given in 20 patients (80%), of which azathioprine alone was given in seven patients (28%), cyclosporin alone was given in two patients (8%), mycophenolate mofetil alone was given in three patients (12%), combination of azathioprine and cyclosporin was given in six patients (24%), and combination of methotrexate and mycophenolate mofetil was given in one patient (4%). Biologics were given in 10 patients (40%) – adalimumab in seven patients (28%) and infliximab in three patients (12%).

Conclusion:
Behcet’s disease is an uncommon uveitis in India. Addition of immunosuppressants and biologics to conventional steroid therapy gives better visual outcomes.
Choroidal metastasis: Radiation and bevacizumab at presentation
Authors: Maheshwari Abhilasha , Finger Paul T 
Published: May 2023

Purpose:
To reveal early intervention outcomes for patients describing with choroidal metastasis.

Methods:
A retrospective interventional case series on 27 eyes of 22 patients treated for choroidal metastasis with external beam radiation therapy (EBRT) With and without intravitreal injections. The prescribed radiation dose was a mean and median 30 Gy (range of 30–40 Gy in 180–200 cGy daily fractions). Outcome measures included change in tumor thickness, subretinal fluid, visual acuity, radiation oculopathy, and survival.

Results:
Decreased vision was the most common presenting symptom (n = 20/27, 74%). Pre-treatment vision for subfoveal lesions was a mean 20/400, median 20/200, and range 20/40 to hand motions (HM). Pre-treatment vision for extrafoveal tumors were a mean 20/40, median 20/25, range 20/20 to counting fingers (CF) which improved to a mean 20/32, median 20/20, range 20/12.5 to 20/200. Local control, with ultrasonographic height regression (44.5%; mean: 2.7–1.5 mm), was observed in all eyes at mean follow-up of 16 months (range: 1–72 months). Intravitreal anti-vascular endothelial growth factor (anti-VEGF) was given in nine cases (n = 9/27, 33%) to slow the growth of the metastasis and suppress their exudative detachments and to treat radiation maculopathy in 10 cases (n = 10/27, 37%). Late radiation complications included keratoconjunctivitis sicca in four cases (n = 4/27, 15%), exposure keratopathy in two cases (n = 2/27, 7%), and radiation retinopathy in 10 cases (n = 10/27, 37%). Of the 23 phakic eyes, four (n = 4, 17%) developed cataract.

Conclusion:
Radiation therapy with or without intravitreal anti-VEGF injections was a safe and effective treatment for choroidal metastasis. It was associated with local tumor control, reduction of secondary retinal detachments, and vision preservation.
Scleral thickness in normal Indian eyes measured using spectral domain anterior segment optical coherence tomography
Authors: Kommula Hasna , Murthy Somasheila I , Loomba Abhinav , Mohamed Ashik , Ranjan Rashmi 
Published: May 2023

Purpose:
To establish normative data on anterior scleral thickness using the spectral domain anterior segment optical coherence tomography (AS-OCT).

Methods:
In total, 200 eyes of 100 healthy subjects underwent AS-OCT scans in the temporal and nasal quadrants. The scleral + conjunctival complex thickness (SCT) was measured by a single examiner. Mean SCT was analyzed for differences across age groups, gender, and location (nasal versus temporal).

Results:
Mean age was 46.4 ± 18.3 (21–84) years; male to female ratio was 54:46. Mean SCT (nasal + temporal) of the right eye (RE) was 682.3 ± 64.2 μm in males and 660.6 ± 57.1 μm in females. In the left eye (LE), it was 684.6 ± 64.9 μm in males and 661.8 ± 49.3 μm in females. These differences between male and female for both eyes were statistically significant (P = 0.006 and P = 0.002). The mean SCT of temporal and nasal quadrants in the RE was 678.54 ± 57.50 and 666 ± 66.2 μm, respectively. In the LE, the temporal mean SCT quadrant was 679.6 ± 55.8 μm, and the nasal was 668.6 ± 63.6 μm. Age had a negative correlation with SCT (−0.62 μm/year; P = 0.03), and males had a higher temporal SCT than females (22 μm higher; P = 0.03). After adjusting for age and gender in a multivariate analysis, temporal SCT was significantly (P < 0.001) higher than nasal SCT.

Conclusion:
In our study, mean SCT decreased with age and males had a higher temporal SCT. This is the first study to evaluate scleral thickness in the Indian population, and the data can be used as a baseline for comparing variations in scleral thickness in disease.
Assessment of the efficacy of olopatadine 0.1% in the treatment of vernal keratoconjunctivitis in terms of clinical improvement based on total ocular symptom score and ocular surface disease index
Authors: Mohan S , Kumar Santosh , Kumar G Pawan , Maheswari Anjali , Bhatia Agrima , Sagar Anand 
Published: May 2023

Purpose:
The main objective of this study is to explore the efficacy of olopatadine 0.1% treatment in the resolution of symptoms of vernal keratoconjunctivitis (VKC) among the Indian population.

Methods:
This single-center, prospective cohort study involved 234 patients with VKC. Patients were treated with olopatadine 0.1%, twice daily for a period of 12 weeks and then followed up in 1st week, 4th week, 3rd month, and 6th month. The extent of relief in the symptoms of VKC was measured using total ocular symptom score (TOSS) and ocular surface disease index (OSDI).

Results:
In the present study, the dropout rate was 5.6%. Total of 136 males and 85 females with a mean age of 37.68 ± 11.35 years completed the study. TOSS score reduced from 58.85 to 5.06 and the OSDI score reduced from 75.41 to 11.2 with statistical significance (P < 0.01) from 1st week to 6th week after olopatadine 0.1% treatment. The data showed relief in subjective symptoms of itching, tearing, and redness, and relief in discomfort in functions related to ocular grittiness, visuals like reading, and environmental like tolerability in dry conditions. Further, olopatadine 0.1% was effective in both males and females, and patients across ages 18–70 years.

Conclusion:
Based on TOSS and OSDI scores, the findings of this study validate safety and tolerability as revealed by low adverse effects and moderate efficacy of olopatadine 0.1% in reducing VKC symptoms in a broader age group (18–70 years) of both genders.
Comparison of the effect of tea tree oil eye gel with standard treatment in patients with anterior blepharitis: An open-label clinical trial
Authors: Aghaei Hossein , Torabi Behrouz , Abdolalizadeh Parya , Vaghfipanah Homa 
Published: May 2023

Purpose:
Daily cleansing of eyelids is very important to carry out a successful blepharitis treatment. However, there are no therapeutic guidelines for blepharitis. The aim was to compare the symptomatic relief of anterior blepharitis using Blephamed eye gel, a cosmetic product, versus standard treatment.

Methods:
The study was a prospective, interventional open label clinical trial at a university-based hospital. The test population was subjects aged 18–65 years who presented with mild to moderate anterior blepharitis. Eyelid hygiene was applied twice a day. At each visit, a detailed assessment of symptomatology was carried out. A two-way repeated measure mixed model ANOVA was used to compare two groups by time.

Results:
In total, 61 patients with mean age of 60.08 ± 16.69 years were enrolled in the study including 30 patients in standard group and 31 patients in Blephamed group. Two groups did not differ in terms of age (P = 0.31) and eye laterality (P = 0.50). The baseline scores of erythema, edema, debris, and symptoms as well as total score were similar between two groups (all P values >0.50). Two groups became different for all these parameters at day 45 (all P values <0.001). Significant interaction was detected between time and intervention groups for all severity parameters of blepharitis as well as total score (all P values <0.001).

Conclusion:
Eyelid hygiene with Blephamed more significantly decreased symptoms of anterior blepharitis compared to standard treatment.
The efficacy of anti–TNF-α agents in the treatment of juvenile idiopathic arthritis-associated uveitis in a pediatric cohort
Authors: ElMohsen Mai Nasser Abd , Hassan Lameece Moustafa , Youssef Maha Mohamed , Naga Shereen H Aboul 
Published: May 2023

Purpose:
Biologic therapy has shown promising control in children with often intractable juvenile idiopathic arthritis (JIA)-associated uveitis (JIA-U).

Methods:
This is a retrospective cohort study of 35 eyes of 35 children who received biologics for JIA-U. Pretreatment and posttreatment data (at 3, 6, 9, 12, 18, 24, and >24 months) were analyzed to determine functional success (stable/improved visual acuity), quiescence success (≤0.5 cells in the anterior chamber), complete steroid success (termination of systemic, periocular therapy and decreased topical drops to ≤2/day) or systemic steroid success (termination of systemic steroids only), and complete success (all of the above).

Results:
This study included 35 eyes up to 12 months and 21 eyes beyond 24 months. Steroid-sparing, functional, and quiescence success showed a rate of success of 52.43%, 77%, and 91%, respectively, at 12 months and 66.67%, 85.7%, and 76.2%, respectively, beyond 24 months. Complete success was 34.29% at 12 months, peaking at 18 months (65.62%) and reached 57.14% beyond 24 months. In their final follow-up, the best corrected visual acuity (BCVA) remained the same in 45.71%, improved in 37.14%, and worsened in 17.14% children.

Conclusion:
Biologic therapy is effective in JIA-U, especially in termination of systemic steroids, stabilization of vision, and maintaining quiescence.
Complications of Descemet stripping endothelial keratoplasty – A retrospective interventional study at a tertiary eye care center in Southern India
Authors: Kodavoor Shreesha Kumar , Patekar Komal B , Ramamoorthy Dandapani 
Published: May 2023

Purpose:
To analyze the visual outcome and complications of Descemet stripping endothelial keratoplasty (DSEK) with their management in 256 eyes at a tertiary eye care center in southern India.

Methods:
This is a retrospective interventional study of 62 months duration conducted at a tertiary eye care center in southern India. Two hundred and fifty-six eyes of 205 patients were included in the study after obtaining written informed consent from the patients. All cases of DSEK were performed by a single experienced surgeon. In all cases, donor dissection was performed manually. A Sheet’s glide was inserted through the temporal corneal incision and donor button was placed on the Sheet’s glide with the endothelial side down. The lenticule was separated and inserted into the anterior chamber by pushing the lenticule into the anterior chamber using Sinskey’s hook. Any complication, either intraoperative or postoperative, was recorded and managed either medically or by appropriate surgical means.

Results:
The mean best corrected visual acuity (BCVA) before surgery was CF-1 m, which improved to 6/18 after surgery. Intraoperative donor graft perforation during dissection was seen in 12 cases, thin lenticule in three eyes, and repeated artificial Anterior Chamber (AC) collapse in three eyes. Dislocation of lenticule was the most common complication seen in 21 eyes, which was managed by graft repositioning and rebubbling. Eleven cases had minimal separation of the graft and seven cases had interface haze. Pupillary block glaucoma was seen in two cases that resolved with partial release of bubble. Surface infiltrate was seen in two cases, which was managed with topical antimicrobial agents. Primary graft failure was seen in two cases.

Conclusion:
DSEK is a promising alternative to penetrating keratoplasty for corneal endothelial decompensation, but it also has its own merits and limitations, and most often, merits overweigh limitations.