bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy Scaling Law for a Singularly Perturbed Four-Gradient Problem in Helimagnetism
Authors: Ginster Janusz , Zwicknagl Barbara 
Published: December 2022

AbstractWe study pattern formation in magnetic compounds near the helimagnetic/ferromagnetic transition point in case of Dirichlet boundary conditions on the spin field. The energy functional is a continuum approximation of a $$J_1-J_3$$

J
1

-

J
3

model and was recently derived in Cicalese et al. (SIAM J Math Anal 51: 4848–4893, 2019). It contains two parameters, one measuring the incompatibility of the boundary conditions and the other measuring the cost of changes between different chiralities. We prove the scaling law of the minimal energy in terms of these two parameters. The constructions from the upper bound indicate that in some regimes branching-type patterns form close to the boundary of the sample.
CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
Authors: Smits Daphne J. , Dekker Jordy , Schot Rachel , Tabarki Brahim , Alhashem Amal , Demmers Jeroen A. A. , Dekkers Dick H. W. , Romito Antonio , van der Spek Peter J. , van Ham Tjakko J. , Bertoli-Avella Aida M. , Mancini Grazia M. S. 
Published: December 2022

AbstractCLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and reportedly localizes to late endosomes. GWAS studies have associated CLEC16A SNPs to various auto-immune and neurological disorders, including multiple sclerosis and Parkinson disease. Studies in mouse models imply a role for CLEC16A in neurodegeneration. We identified bi-allelic CLEC16A truncating variants in siblings from unrelated families presenting with a severe neurodevelopmental disorder including microcephaly, brain atrophy, corpus callosum dysgenesis, and growth retardation. To understand the function of CLEC16A in neurodevelopment we used in vitro models and zebrafish embryos. We observed CLEC16A localization to early endosomes in HEK293T cells. Mass spectrometry of human CLEC16A showed interaction with endosomal retromer complex subunits and the endosomal ubiquitin ligase TRIM27. Expression of the human variant leading to C-terminal truncated CLEC16A, abolishes both its endosomal localization and interaction with TRIM27, suggesting a loss-of-function effect. CLEC16A knockdown increased TRIM27 adhesion to early endosomes and abnormal accumulation of endosomal F-actin, a sign of disrupted vesicle sorting. Mutagenesis of clec16a by CRISPR–Cas9 in zebrafish embryos resulted in accumulated acidic/phagolysosome compartments, in neurons and microglia, and dysregulated mitophagy. The autophagocytic phenotype was rescued by wild-type human CLEC16A but not the C-terminal truncated CLEC16A. Our results demonstrate that CLEC16A closely interacts with retromer components and regulates endosomal fate by fine-tuning levels of TRIM27 and polymerized F-actin on the endosome surface. Dysregulation of CLEC16A-mediated endosomal sorting is associated with neurodegeneration, but it also causes accumulation of autophagosomes and unhealthy mitochondria during brain development.
Intersektionale Diskriminierung: Erfahrungen und Perspektiven in der Psychotherapie mit Frauen mit Fluchtbiografien
Authors: Tiefenthaler Sabine 
Published: December 2022

ZusammenfassungDer folgende Beitrag setzt sich mit dem Einfluss intersektionaler Diskriminierungserfahrungen von geflüchteten Frauen auf das psychische Wohlbefinden und mit der Frage, wie diese Erfahrungen in der Psychotherapie bearbeitet werden können, auseinander.In diesem Zusammenhang werden die Ergebnisse einer Studie vorgestellt, in welcher Interviews mit Psychotherpeut*innen durchgeführt wurden und sich bei der Analyse drei zentrale Dimensionen herauskristallisiert haben. Diese geben Aufschluss darüber, wie intersektionale Diskriminierung von geflüchteten Frauen in der Psychotherapie thematisiert wird, wie damit in der Therapie umgegangen wird und welche Herausforderungen und Bedarfe sich daraus für die Praxis ergeben. Anhand der Ergebnisse werden Elemente einer machtsensiblen Haltung für den Umgang mit intersektionalen Diskriminierungserfahrungen geflüchteter Frauen in der Psychotherapie herausgearbeitet.
Polyantimonic acid-based materials evaluated as moisture sensors at ambient temperature
Authors: Mendes Sofia , Kurapova Olga , Faia Pedro , Pazheltsev Vasily , Zaripov Artem , Konakov Vladimir 
Published: December 2022

AbstractHumidity sensors are in high demand for many applications, such as environmental monitoring and air and food quality control. Despite many inorganic and organic materials exhibit moisture sensing properties, the electrical response of many existing sensors is not stable along the time. Polyantimonic acid (PAA) is characterized by elevated proton conductivity and by high thermal stability: consequently, it is seen as promising proton conductor for usage in humidity sensing devices. In this work, for the first time, PAA-based bulk solid membranes were produced and tested as potential materials for relative humidity (RH) detection and their moisture sensitivity was evaluated. Two different amounts of binder were used for moulding the solid sensors: the ones with 10% of binder were designated as 90PAA, while the ones with 20% were named 80PAA. The structures of the solid samples were investigated by X-ray diffraction (XRD) technique, adsorption–desorption curves via Brunauer–Emmett–Teller (BET), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) techniques. The electrical behaviour was examined at ambient temperature by electrical impedance spectroscopy in the entire relative humidity (RH) interval (0–100%) and in the frequency range of 40 Hz up to 60 MHz. Electrical response of the materials was correlated with the structural features of the membranes. Both 90PAA and 80PAA sensors showed total resistance 3 × 105 and 3.5 × 105 Ω at 10% RH, respectively. A linear decrease of the resistance on RH was observed in the range 30–90% RH for both sensors. The electrical response of the evaluated PAA-based sensors displays good repeatability and reproducibility: the ones with lower binder content showed higher moisture sensitivity as well as very good time stability over 1 year.
Information sharing through digitalisation in decentralised supply chains
Authors: Zissis Dimitris 
Published: December 2022

AbstractThis study investigates the impact of private information on decision making process and how emerging technologies can facilitate information sharing and reduce misinformation in decentralised settings. Focusing on business environments, we examine if information sharing between distinct partners can be a mutually beneficial option. In principle, information affects the preferences and the actions of decision makers and usually contributes to inefficiencies for the entire system. A supply chain with two rational firms is considered; the firms have conflicting objectives and possess information that cannot be verified. Real-time communication through a cloud platform is allowed, before the firms finalise their strategies. During the communication phase, both firms are free to report whatever information optimises their individual objectives, even fake. Misinformation seems a plausible option, especially in competitive environments, since the firms may take advantages from such behaviour. We demonstrate that sharing the actual information can be beneficial for both, under the implementation of an appropriate mechanism that considers the welfare of the entire chain. Despite the individualistic behaviour of independent decision makers, it is doable to eliminate entirely information asymmetry and misinformation. This happens by including sufficient incentives on a mechanism that induce firms to reveal their information, because it is in their self-interest to do so. The value of information and the expected benefits of the voluntary information sharing are calculated, indicating the potential improvement.
New field technique to determine in-situ gross nitrification rates on an intact 4 m2 scale on arable land
Authors: Stange C. F. , Jaquemotte J. , Gabriel F. , Stadler S. 
Published: December 2022

AbstractNitrification is one major part of the terrestrial nitrogen cycle and is responsible for the N supply to microbes and plants. Furthermore, it opens N-loss pathways. Quantifying actual gross rates of nitrification is of growing interest due to the risk of nitrate-N leaching into groundwater. Gross nitrification measurements are often conducted either in disturbed soils or in small intact soil cores. Both approaches can have methodological issues. Our study presents a newly developed technique at an intact 2 × 2 m2field scale that was tested extensively on agricultural (sandy) soils. The irrigation technique allowed for a uniform distribution of15NO3−using a tracer solution. It further enabled a calculation of gross nitrification rates directly in the field. The gross nitrification rates within the 4 m2plots were highly variable. Individual plots showed gross nitrification rates between 3.9 and 17.9 µmol kg−1 soil d−1. At the chosen meter scale, the dependency of the nitrification rate on environmental and soil parameters could be observed. Nitrification was influenced by the mean soil temperature during field incubation. Nitrification rates normalized for temperature (20 °C) showed a negative linear correlation with the C/N ratio of the plots (r2 = 0.78).
Strategic effects of stock pollution: the positive theory of fiscal deficits revisited
Authors: Kellner Maximilian 
Published: December 2022

AbstractThis article introduces a dynamic political-economy model of public debt which integrates climate policy. Strategic incentives are shaped by both an emission interaction and a budget interaction if public good provision contributes to a stock of persistent pollution. In a bipartisan system, politicians, who disagree on the optimal internalization of pollution, compete for office. The central finding is that bequeathing a large stock of pollution to the future government is not optimal for any incumbent regardless of their environmental preferences. This leads to strategic emission abatement in the first period. Additionally, while the incumbent engages in strategic deficit spending when reelection is uncertain, this effect is no longer necessarily inefficient when accounting for stock pollution. Both effects may increase welfare as a direct result of reelection uncertainty.
Solar Cycle 25 Prediction Using an Optimized Long Short-Term Memory Mode with F10.7
Authors: Zhu Hongbing , Zhu Wenwei , He Mu 
Published: December 2022

AbstractIn this paper, an optimized long short-term memory (LSTM) model is proposed to deal with the smoothed monthly $F_{10.7}$

F
10.7

data, aiming to predict the peak amplitude of $F_{10.7}$

F
10.7

and the occurring time for Solar Cycle 25 (SC-25) to obtain the maximum amplitude of sunspot number (SSN) and the reaching time. The “re-prediction” process in the model uses the latest prediction results obtained from the previous prediction as the input for the next prediction calculation. The prediction errors between the predicted and observed peak amplitude of $F_{10.7}$

F
10.7

for SC-23 and SC-24 are 2.87% and 1.09%, respectively. The predicted peak amplitude of $F_{10.7}$

F
10.7

for SC-25 is 156.3, and the maximum value of SSN is calculated as 147.9, which implies that SC-25 will be stronger than SC-24. SC-25 will reach its peak in July 2025.
Leaky Gut Plays a Critical Role in the Pathophysiology of Autism in Mice by Activating the Lipopolysaccharide-Mediated Toll-Like Receptor 4–Myeloid Differentiation Factor 88–Nuclear Factor Kappa B Signaling Pathway
Authors: Li Fang , Ke Haoran , Wang Siqi , Mao Wei , Fu Cexiong , Chen Xi , Fu Qingqing , Qin Xiaori , Huang Yonghua , Li Bidan , Li Shibing , Xing Jingying , Wang Minhui , Deng Wenlin 
Published: December 2022

AbstractIncreased intestinal barrier permeability, leaky gut, has been reported in patients with autism. However, its contribution to the development of autism has not been determined. We selected dextran sulfate sodium (DSS) to disrupt and metformin to repair the intestinal barrier in BTBR T+tf/J autistic mice to test this hypothesis. DSS treatment resulted in a decreased affinity for social proximity; however, autistic behaviors in mice were improved after the administration of metformin. We found an increased affinity for social proximity/social memory and decreased repetitive and anxiety-related behaviors. The concentration of lipopolysaccharides in blood decreased after the administration of metformin. The expression levels of the key molecules in the toll-like receptor 4 (TLR4)–myeloid differentiation factor 88 (MyD88)–nuclear factor kappa B (NF-κB) pathway and their downstream inflammatory cytokines in the cerebral cortex were both repressed. Thus, “leaky gut” could be a trigger for the development of autismviaactivation of the lipopolysaccharide-mediated TLR4–MyD88–NF-κB pathway.
Endophytic fungi Aspergillus spp. reduce fusarial wilt disease severity, enhance growth, metabolism and stimulate the plant defense system in pepper plants
Authors: Attia Mohamed S. , Salem Marwa S. , Abdelaziz Amer M. 
Published: December 2022

Abstract
Plants in various republics of the world face many dangers, including diseases that threaten crop productivity. The development and increase of novel species of infectious pathogens have made plant growth threatened. Fusarium wilt is one of the fiercest diseases affecting vegetables, which causes a great loss in the quality and quantity of pepper plants all over the world. In this study, stimulation of physiological immune responses in pepper plant using ecofriendly inducers (Aspergillus alabamensis, Aspergillus oryzae, and Aspergillus tubingensis) against Fusarium wilt had been studied. Endophytic fungi were assayed for their capability to synthesize hydrocyanic acid, phosphate solubilization, siderophores, and indole acetic acid synthesis, and the antifungal potential of ecofriendly inducers against F. oxysporum was also examined. A notable antifungal potential antifusarial with a supreme activity of A. tubingensis was found. More ultrastructure by TEM of Fusarium showed that sharp changes occurred in the cell wall, mycelium, and conidia as a result of treatment with A. tubingensis, A. oryzae, and A. alabamensis. The results demonstrated the high severity of F. oxysporum on pepper seedlings. Infected seedlings showed a high reduction in all vegetative parameters, photosynthesis, entire protein, and total carbohydrate. In the current study, the potential of endophytic fungi through foliar and soil application was applied to the Fusarium-infected pepper plants under pot conditions. Disease index, vegetative growth, photosynthetic pigments, osmolyte content, stress markers, and antioxidant isozymes were assessed. The achieved result indicates that tested endophytes through two modes (foliar and soil) lowered PDI and produced high protection, with the most protection influence represented by A. tubingensis (through the soil) by 83.33%. It was concluded that use of A. tubingensis, A. alabamensis, and A. oryzae could be commercially used as eco-friendly agents for the defense of pepper seedlings against Fusarium wilt disease.
Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting
Authors: Aizawa Yoshihiro , Takada Kentaro , Aoyama Jun , Sano Daisuke , Yamanaka Shoji , Seki Masahide , Kuze Yuta , Ramilowski Jordan A. , Okuda Ryo , Ueno Yasuharu , Nojima Yusuke , Inayama Yoshiaki , Hatakeyama Hiromitsu , Hatano Takashi , Takahashi Hideaki , Nishimura Goshi , Fujii Satoshi , Suzuki Yutaka , Taniguchi Hideki , Oridate Nobuhiko 
Published: December 2022

Abstract
Purpose
Depending on its histological subtype, salivary gland carcinoma (SGC) may have a poor prognosis. Due to the scarcity of preclinical experimental models, its molecular biology has so far remained largely unknown, hampering the development of new treatment modalities for patients with these malignancies. The aim of this study was to generate experimental human SGC models of multiple histological subtypes using patient-derived xenograft (PDX) and organoid culture techniques.

Methods
Tumor specimens from surgically resected SGCs were processed for the preparation of PDXs and patient-derived organoids (PDOs). Specimens from SGC PDXs were also processed for PDX-derived organoid (PDXO) generation. In vivo tumorigenicity was assessed using orthotopic transplantation of SGC organoids. The pathological characteristics of each model were compared to those of the original tumors using immunohistochemistry. RNA-seq was used to analyze the genetic traits of our models.

Results
Three series of PDOs, PDXs and PDXOs of salivary duct carcinomas, one series of PDOs, PDXs and PDXOs of mucoepidermoid carcinomas and PDXs of myoepithelial carcinomas were successfully generated. We found that PDXs and orthotopic transplants from PDOs/PDXOs showed similar histological features as the original tumors. Our models also retained their genetic traits, i.e., transcription profiles, genomic variants and fusion genes of the corresponding histological subtypes.

Conclusion
We report the generation of SGC PDOs, PDXs and PDXOs of multiple histological subtypes, recapitulating the histological and genetical characteristics of the original tumors. These experimental SGC models may serve as a useful resource for the development of novel therapeutic strategies and for investigating the molecular mechanisms underlying the development of these malignancies.
The False Economy of Seeking to Eliminate Delayed Transfers of Care: Some Lessons from Queueing Theory
Authors: Wood Richard M. , Harper Alison L. , Onen-Dumlu Zehra , Forte Paul G. , Pitt Martin , Vasilakis Christos 
Published: December 2022

Abstract
Background
It is a stated ambition of many healthcare systems to eliminate delayed transfers of care (DTOCs) between acute and step-down community services.

Objective
This study aims to demonstrate how, counter to intuition, pursual of such a policy is likely to be uneconomical, as it would require large amounts of community capacity to accommodate even the rarest of demand peaks, leaving much capacity unused for much of the time.

Methods
Some standard results from queueing theory—a mathematical discipline for considering the dynamics of queues and queueing systems—are used to provide a model of patient flow from the acute to community setting. While queueing models have a track record of application in healthcare, they have not before been used to address this question.

Results
Results show that ‘eliminating’ DTOCs is a false economy: the additional community costs required are greater than the possible acute cost saving. While a substantial proportion of DTOCs can be attributed to inefficient use of resources, the remainder can be considered economically essential to ensuring cost-efficient service operation. For England’s National Health Service (NHS), our modelling estimates annual cost savings of £117m if DTOCs are reduced to the 12% of current levels that can be regarded as economically essential.

Conclusion
This study discourages the use of ‘zero DTOC’ targets and instead supports an assessment based on the specific characteristics of the healthcare system considered.
No Strings Attached to GIs? About a Blind Spot in the (Academic) Discourse on Limitations and Fundamental Rights
Authors: Kur Annette 
Published: December 2022

AbstractDuring the last decades, the focus of academic discourse on intellectual property rights has been on limitations and exceptions, with a strong accent on fundamental rights. However, until now such debates never involved protection of geographical indications under the sui generis system established in the European Union. That is quite remarkable. Already in its current form, the scope of protection granted to such rights is rather broad, as was confirmed and reinforced in the case law of the Court of Justice of the European Union. According to pending proposals, the scope and ambit of protection shall be strengthened further, without any counterbalance in the form of limitations being envisaged. This opinion argues that turning a blind eye to those developments is no commendable attitude for those concerned about imbalances in intellectual property rights.
Supporting Inquiry Learning: an Intellectual Mirror that Describes what It “Sees”
Authors: Yerushalmy Michal , Olsher Shai , Harel Raz , Chazan Daniel 
Published: December 2022

AbstractMuch
important research on the learning of mathematics with technology-supported inquiry has been devoted to learning with multiple-linked representations (MLR) as a mode of feedback. Like a mirror, MLR feedback helps students see their actions in one representation “reflected” in another. Yet, research has followed learning episodes where MLR feedback did not lead to concept formation and the achievement of curricular goals. This article reports on the potential of what might be thought of as a mirror that speaks. In response to example-eliciting tasks, students use interactive diagrams to create examples to which mathematical descriptions are automatically associated. Such descriptions may be thought of as another kind of linked mathematical representation system. Transitions feature in two ways in our analysis of students’ use of this representation. At the level of student activity, we examine when students move between attending to textual descriptions and to the graphs that they describe. We are also interested in how attention to these descriptions and co-ordination with their own use of these words can support students in making a transition in their thinking from considering distance as only total distance traveled, to a co-ordinated view of distance including both total distance traveled and distance from a starting point. This article focuses on two example-eliciting motion tasks and two sets of descriptive words. We found that these sets of words helped students, while and after they were working with the diagram, to distinguish between total distance traveled and position with respect to a starting point.
Multidiscipline Applications of Triboelectric Nanogenerators for the Intelligent Era of Internet of Things
Authors: Cao Xiaole , Xiong Yao , Sun Jia , Xie Xiaoyin , Sun Qijun , Wang Zhong Lin 
Published: December 2022

AbstractIn the era of 5G and the Internet of things (IoTs), various human–computer interaction systems based on the integration of triboelectric nanogenerators (TENGs) and IoTs technologies demonstrate the feasibility of sustainable and self-powered functional systems. The rapid development of intelligent applications of IoTs based on TENGs mainly relies on supplying the harvested mechanical energy from surroundings and implementing active sensing, which have greatly changed the way of human production and daily life. This review mainly introduced the TENG applications in multidiscipline scenarios of IoTs, including smart agriculture, smart industry, smart city, emergency monitoring, and machine learning-assisted artificial intelligence applications. The challenges and future research directions of TENG toward IoTs have also been proposed. The extensive developments and applications of TENG will push forward the IoTs into an energy autonomy fashion.