bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells
Authors: Ross Ewan A. , Turner Lesley-Anne , Donnelly Hannah , Saeed Anwer , Tsimbouri Monica P. , Burgess Karl V. , Blackburn Gavin , Jayawarna Vineetha , Xiao Yinbo , Oliva Mariana A. G. , Willis Jennifer , Bansal Jaspreet , Reynolds Paul , Wells Julia A. , Mountford Joanne , Vassalli Massimo , Gadegaard Nikolaj , Oreffo Richard O. C. , Salmeron-Sanchez Manuel , Dalby Matthew J. 
Published: February 2023

AbstractMesenchymal stromal cells (MSCs) are multipotent progenitor cells that are of considerable clinical potential in transplantation and anti-inflammatory therapies due to their capacity for tissue repair and immunomodulation. However, MSCs rapidly differentiate once in culture, making their large-scale expansion for use in immunomodulatory therapies challenging. Although the differentiation mechanisms of MSCs have been extensively investigated using materials, little is known about how materials can influence paracrine activities of MSCs. Here, we show that nanotopography can control the immunomodulatory capacity of MSCs through decreased intracellular tension and increasing oxidative glycolysis. We use nanotopography to identify bioactive metabolites that modulate intracellular tension, growth and immunomodulatory phenotype of MSCs in standard culture and during larger scale cell manufacture. Our findings demonstrate an effective route to support large-scale expansion of functional MSCs for therapeutic purposes.
Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice
Authors: Lu Hanlin , Yuan Peidong , Ma Xiaoping , Jiang Xiuxin , Liu Shaozhuang , Ma Chang , Philipsen Sjaak , Zhang Qunye , Yang Jianmin , Xu Feng , Zhang Cheng , Zhang Yun , Zhang Wencheng 
Published: February 2023

AbstractAngiogenesis is a critical pathophysiological process involved in organ growth and various diseases. Transcription factors Sp1/Sp3 are necessary for fetal development and tumor growth. Sp1/Sp3 proteins were downregulated in the capillaries of the gastrocnemius in patients with critical limb ischemia samples. Endothelial-specific Sp1/Sp3 knockout reduces angiogenesis in retinal, pathological, and tumor models and induced activation of the Notch1 pathway. Further, the inactivation of VEGFR2 signaling by Notch1 contributes to the delayed angiogenesis phenotype. Mechanistically, endothelial Sp1 binds to the promoter of Notch1 and inhibits its transcription, which is enhanced by Sp3. The proangiogenic effect of ACEI is abolished in Sp1/Sp3-deletion male mice. We identify USP7 as an ACEI-activated deubiquitinating enzyme that translocated into the nucleus binding to Sp1/Sp3, which are deacetylated by HDAC1. Our findings demonstrate a central role for endothelial USP7-Sp1/Sp3-Notch1 signaling in pathophysiological angiogenesis in response to ACEI treatment.
Polymer-dispersed liquid crystal elastomers as moldable shape-programmable material
Authors: Bobnar Matej , Derets Nikita , Umerova Saide , Domenici Valentina , Novak Nikola , Lavrič Marta , Cordoyiannis George , Zalar Boštjan , Rešetič Andraž 
Published: February 2023

AbstractThe current development of soft shape-memory materials often results in materials that are typically limited to the synthesis of thin-walled specimens and usually rely on complex, low-yield manufacturing techniques to fabricate macro-sized, solid three-dimensional objects. However, such geometrical limitations and slow production rates can significantly hinder their practical implementation. In this work, we demonstrate a shape-memory composite material that can be effortlessly molded into arbitrary shapes or sizes. The composite material is made from main-chain liquid crystal elastomer (MC-LCE) microparticles dispersed in a silicone polymer matrix. Shape-programmability is achieved via low-temperature induced glassiness and hardening of MC-LCE inclusions, which effectively freezes-in any mechanically instilled deformations. Once thermally reset, the composite returns to its initial shape and can be shape-programmed again. Magnetically aligning MC-LCE microparticles prior to curing allows the shape-programmed artefacts to be additionally thermomechanically functionalized. Therefore, our material enables efficient morphing among the virgin, thermally-programmed, and thermomechanically-controlled shapes.
Global patterns of water storage in the rooting zones of vegetation
Authors: Stocker Benjamin D. , Tumber-Dávila Shersingh Joseph , Konings Alexandra G. , Anderson Martha C. , Hain Christopher , Jackson Robert B. 
Published: February 2023

AbstractThe rooting-zone water-storage capacity—the amount of water accessible to plants—controls the sensitivity of land–atmosphere exchange of water and carbon during dry periods. How the rooting-zone water-storage capacity varies spatially is largely unknown and not directly observable. Here we estimate rooting-zone water-storage capacity globally from the relationship between remotely sensed vegetation activity, measured by combining evapotranspiration, sun-induced fluorescence and radiation estimates, and the cumulative water deficit calculated from daily time series of precipitation and evapotranspiration. Our findings indicate plant-available water stores that exceed the storage capacity of 2-m-deep soils across 37% of Earth’s vegetated surface. We find that biome-level variations of rooting-zone water-storage capacities correlate with observed rooting-zone depth distributions and reflect the influence of hydroclimate, as measured by the magnitude of annual cumulative water-deficit extremes. Smaller-scale variations are linked to topography and land use. Our findings document large spatial variations in the effective root-zone water-storage capacity and illustrate a tight link among the climatology of water deficits, rooting depth of vegetation and its sensitivity to water stress.
Surfactants alter mosquito’s flight and physical condition
Authors: Kato-Namba Aya , Iida Toshiaki , Ohta Kazumi , Suzuki Masahiro , Saito Kazuma , Takeuchi Kohei , Sakamoto Maki , Kazama Hokto , Nakagawa Takao 
Published: February 2023

AbstractMosquitoes carry lethal pathogens for humans and hundreds of thousands of people are killed by mosquito-borne diseases every year. Therefore, controlling mosquitoes is essential to protect the lives of people around the world. Insecticides are highly effective in controlling mosquitoes and have been used extensively worldwide. However, they have potentially harmful effects on biodiversity and environment, and some mosquitoes are resistant to insecticide ingredients and survive upon their application. Therefore, there is a demand for a method to control mosquitoes without using conventional insecticide ingredients. Here, we used Aedes albopictus to test whether solutions with low surface tension, particularly surfactant solutions can alter mosquito behavior by spreading over the hydrophobic cuticle of mosquitoes. We found that solutions with low surface tension indeed attached to mosquitoes flying or resting on the wall, and made them fall. In addition, solutions with yet lower surface tension covered the mosquito surface more quickly and widely, knocking down or killing mosquitoes. These results suggest that surfactants such as sodium dioctyl sulfosuccinate can be used to alter mosquito behavior without relying on conventional insecticides.
Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach
Authors: Katagiri Ryoko , Goto Atsushi , Nakano Shiori , Nakatochi Masahiro , Koyanagi Yuriko N. , Iwagami Masao , Hanyuda Akiko , Yamaji Taiki , Sawada Norie , Nakamura Yohko , Nakamura Sho , Kuriki Kiyonori , Suzuki Sadao , Imoto Issei , Momozawa Yukihide , Oze Isao , Ito Hidemi , Tsugane Shoichiro , Wakai Kenji , Matsuo Keitaro , Iwasaki Motoki 
Published: February 2023

AbstractThe association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentrations were systematically selected according to the “GWAS Catalog” from all ethnic populations. For the SNP-vitamin D concentration association, 3978 individuals from two Japanese cohorts were included. Regarding SNP-total and colorectal cancer association, 4543 cancer cases and 14,224 controls and 7936 colorectal cancer cases and 38,042 controls, respectively were included from the Japanese Consortium of Genetic Epidemiology and other studies in Japan. There was no significant association between the genetically predicted plasma 25-hydroxyvitamin D concentration and total or colorectal cancer in any of the MR analyses. Odds ratios per doubling in vitamin D concentration were 0.83 (95% confidence interval [CI] 0.63–1.09) for total cancer and 1.00 (95% CI 0.80–1.24) for colorectal cancer in inverse variance weighted method, 0.83 (95% CI 0.57–1.19) for total cancer and 1.01 (95% CI 0.75–1.37) for colorectal cancer in MR-Egger method. Consistent with previous MR analyses among European ancestries, there was no significant association identified between 25-hydroxyvitamin D levels and total or colorectal cancer among Asians.
Patterns of Arc mRNA expression in the rat brain following dual recall of fear- and reward-based socially acquired information
Authors: Agee Laura A. , Hilz Emily N. , Jun Dohyun , Nemchek Victoria , Lee Hongjoo J. , Monfils Marie-H. 
Published: February 2023

AbstractLearning can occur via direct experience or through observation of another individual (i.e., social learning). While research focused on understanding the neural mechanisms of direct learning is prevalent, less work has examined the brain circuitry mediating the acquisition and recall of socially acquired information. Here, we aimed to further elucidate the mechanisms underlying recall of socially acquired information by having male and female rats sequentially recall a socially transmitted food preference (STFP) and a fear association via fear conditioning by-proxy (FCbP). Brain tissue was processed for mRNA expression of the immediate early gene (IEG)Arc, which expresses in the nucleus following transcription before migrating to the cytoplasm over the next 25 min. Given this timeframe, we could identify whetherArctranscription was triggered by STFP recall, FCbP recall, or both. Contrary to past research, we found no differences in anyArcexpression measures across a number of prefrontal regions and the ventral CA3 of the hippocampus between controls, demonstrators, and observers. We theorize that these results may indicate that relatively littleArc-dependent neural restructuring is taking place in the prefrontal cortices and ventral CA3 following recall of recently socially acquired information or directly acquired fear associations in these areas.
Assessing overdiagnosis of fecal immunological test screening for colorectal cancer with a digital twin approach
Authors: Lin Ting-Yu , Chiu Sherry Yueh-Hsia , Liao Ling-Chun , Chen Sam Li-Sheng , Chiu Han-Mo , Chen Tony Hsiu-Hsi 
Published: February 2023

AbstractEvaluating the magnitude of overdiagnosis associated with stool-based service screening for colorectal cancer (CRC) beyond a randomized controlled trial is often intractable and understudied. We aim to estimate the proportion of overdiagnosis in population-based service screening programs for CRC with the fecal immunochemical test (FIT). The natural process of overdiagnosis-embedded disease was first built up to learn transition parameters that quantify the pathway of non-progressive and progressive screen-detected cases calibrated with sensitivity, while also taking competing mortality into account. The Markov algorithms were then developed for estimating these transition parameters based on Taiwan FIT service CRC screening data on 5,417,699 residents aged 50–69 years from 2004 to 2014. Following the digital twin design with the parallel universe structure for emulating the randomized controlled trial, the screened twin, mirroring the control group without screening, was virtually recreated by the application of the above-mentioned trained parameters to predict CRC cases containing overdiagnosis. The ratio of the predicted CRCs derived from the screened twin to the observed CRCs of the control group minus 1 was imputed to measure the extent of overdiagnosis. The extent of overdiagnosis for invasive CRCs resulting from FIT screening is 4.16% (95% CI: 2.61–5.78%). The corresponding figure is increased to 9.90% (95% CI: 8.41–11.42%) for including high grade dysplasia (HGD) and further inflated to 15.83% (95% CI: 15.23–16.46%) when the removal adenoma is considered. The modest proportion of overdiagnosis modelled by the digital twin method, dispensing with the randomized controlled trial design, suggests the harm done to population-based FIT service screening is negligible.
The role of extracellular vesicles in intercellular communication in human reproduction
Authors: Gonzalez Fernandez Javier , Moncayo Arlandi Javier , Ochando Ana , Simon Carlos , Vilella Felipe 
Published: February 2023

Abstract
Embryo–maternal cross-talk has emerged as a vitally important process for embryo development and implantation, which is driven by secreted factors and extracellular vesicles (EVs). The EV cargo of bioactive molecules significantly influences target cells and primes them for critical stages of reproductive biology, including embryo development, adhesion, and implantation. Recent research has suggested that EVs and their cargo represent a powerful non-invasive tool that can be leveraged to assess embryo and maternal tissue quality during assisted reproduction treatments.
Here, we review the current scientific literature regarding the intercellular cross-talk between embryos and maternal tissues from fertilization to implantation, focusing on human biology and signaling mechanisms identified in animal models.
Simulation‐data‐driven load disaggregation based on multi‐channel neural network for industrial and commercial users
Authors: Yang Xiu , Jiang Qian , Sun Gaiping , Tian Yingjie 
Published: February 2023

AbstractThe immeasurable energy‐saving potential of industrial parks and commercial buildings with unprecedented growth in scale and quantity can be well exploited by load disaggregation, a promising technique for demand‐side refinement management. However, traditional load disaggregation studies mainly focus on residential users and neglect the collection and analysis of industrial and commercial loads. This study employs a simulated response model of versatile load categories with voltage‐dependent load functions to overcome the unavailability of industrial and commercial datasets. Specially, a weighting factors allocation method considering probability statistics of power consumption distribution characteristics is proposed to construct a typical daily multi‐type load aggregation model. Furthermore, an intelligent load disaggregation strategy is developed based on a multi‐channel neural network to constructively improve multi‐feature tracking and convergence efficiency. Finally, the simulation results of the detailed study case confirm the tractability and effectiveness of the proposed approach to carry out load identification among multi‐type users, with an accuracy of 94.9% and errors of individual categories controlled between 3.32% and 10.686%. Moreover, additional interference tests demonstrate that the developed model has superiority over common load disaggregation structures, with better tolerance to exceptional voltage fluctuation and noise.
How the origin of stars in the Galaxy impacts the composition of planetary building blocks
Authors: Cabral N. , Guilbert-Lepoutre A. , Bitsch B. , Lagarde N. , Diakite S. 
Published: February 2023

Context. Our Galaxy is composed of different stellar populations with varying chemical abundances, which are thought to imprint the composition of planet building blocks (PBBs). As such, the properties of stars should affect the properties of planets and small bodies formed in their systems. In this context, high-resolution spectroscopic surveys open a window into the chemical links between and their host stars.
Aims. We aim to determine the PBB composition trends for various stellar populations across the Galaxy by comparing the two large spectroscopic surveys APOGEE and GALAH. We assess the reliability of the PBB composition as determined with these surveys with a propagation error study.
Methods. Stellar spectroscopic abundances from the large surveys GALAH-DR3 and APOGEE-DR17 were used as input with a stoichiometric condensation model. We classified stars into different Galactic components and we quantified the PBB composition trends as a function of [Fe/H]. We also analysed the distribution composition patterns in the [α/Fe]–[Fe/H] diagram.
Results. Our propagation error study suggests that the overall trends with [Fe/H] and [α/Fe] are robust, which is supported by the double study of both APOGEE and GALAH. We therefore confirm the existence of a bimodal PBB composition separating the thin disc stars from the thick disc stars. Furthermore, we confirm that the stoichiometric water PBB content is anti-correlated with [Fe/H].
Conclusions. Our results imply that metal-poor stars both in the thin and thick disks are suitable hosts for water-rich PBBs and for ice-rich small bodies. However, for metal-poor stars ([Fe/H]<0), the PBBs around thick disc stars should have a higher water content than that around thin disc stars because of the α-content dependence of the water mass fraction. Given the importance of the initial water abundance of the PBBs in recent planet formation simulations, we expect that the star origin influences the exoplanet population properties across the Galaxy.
CHEX-MATE: Pressure profiles of six galaxy clusters as seen by SPT and Planck
Authors: Oppizzi F. , De Luca F. , Bourdin H. , Mazzotta P. , Ettori S. , Gastaldello F. , Kay S. , Lovisari L. , Maughan B. J. , Pointecouteau E. , Pratt G. W. , Rossetti M. , Sayers J. , Sereno M. 
Published: February 2023

Context. Pressure profiles are sensitive probes of the thermodynamic conditions and the internal structure of galaxy clusters. The intra-cluster gas resides in hydrostatic equilibrium within the dark-matter gravitational potential. However, this equilibrium may be perturbed; for example, as a consequence of thermal energy losses, feedback, and non-thermal pressure supports. Accurate measures of the gas pressure over cosmic time are crucial for constraining cluster evolution as well as the contributions from astrophysical processes.
Aims. In this work we present a novel algorithm for deriving the pressure profiles of galaxy clusters from the Sunyaev-Zeldovich (SZ) signal measured on a combination of Planck and South Pole Telescope (SPT) observations. The synergy of the two instruments makes it possible to track the profiles on a wide range of spatial scales. We exploited the sensitivity of the Planck High-Frequency Instrument to the larger scales in order to observe the faint peripheries, and took advantage of the higher spatial resolution of SPT to solve the innermost regions.
Methods. We developed a two-step pipeline to take advantage of the specifications of each instrument. We first performed a component separation on the two data sets separately in order to remove the background (CMB) and foreground (Galactic emission) contaminants. We then jointly fitted a parametric pressure profile model on a combination of Planck and SPT data.
Results. We validated our technique on a sample of six CHEX-MATE clusters detected by SPT. We compare the results of the SZ analysis with profiles derived from X-ray observations with XMM-Newton. We find excellent agreement between these two independent probes of the gas pressure structure.
Evidence-Based Medicine: The Role of Nasal Surgery in Treatment of Obstructive Sleep Apnea
Authors: Newsome Hillary 
Published: February 2023

AbstractNasal surgery performed for the management of obstructive sleep apnea includes septoplasty with and without inferior turbinate reduction and functional rhinoplasty. There is controversy over the effectiveness of these techniques in terms of their ability to decrease apnea-hypopnea index. However, it is fairly accepted that nasal surgery can improve sleep-related quality of life measures. This review focuses on the recently published evidence surrounding the role of nasal surgery in obstructive sleep apnea. Findings suggest that functional rhinoplasty may improve apnea–hypopnea index (AHI) in patients with mild OSA. The effect of septoplasty on AHI is less consistent. Further studies are needed to better clarify the role for both septoplasty and functional rhinoplasty in the OSA treatment algorithm.
Role of Helicopter Transfer and Cloud-Type Imaging for Acute Type A Aortic Dissection
Authors: Ishikawa Natsuya , Narita Masahiko , Shirasaka Tomonori , Ushioda Ryouhei , Tsutsui Masahiro , Azuma Nobuyoshi , Kamiya Hiroyuki 
Published: February 2023

Abstract
Background This study explored if long-distance transfer was safe for patients suffering from acute aortic dissection type A (AADA) and also analyzed the effectiveness of helicopter transfer and cloud-type imaging transfer systems for such patients in northern Hokkaido, Japan.
Methods and Results The study included 112 consecutive patients who underwent emergency surgical treatment for AADA from April 2014 to September 2020. The patients were divided into two groups according to the location of referral source hospitals: the Asahikawa city group (group A, n = 49) and the out-of-the-city group (group O, n = 63). Use of helicopter transfer (n = 13) and cloud-type telemedicine (n = 20) in group O were reviewed as subanalyses.Transfer distance differed between groups (4.2 ± 3.5 km in group A vs 107.3 ± 69.2 km in group O; p = 0.0001), but 30-day mortality (10.2% in group A vs 7.9% in group O; p = 0.676) and hospital mortality (12.2% in group A vs 9.5% in group O; p = 0.687) did not differ. Operative outcomes did not differ with or without helicopter and cloud-type telemedicine, but diagnosis-to-operation time was shorter with helicopter (240.0 ± 70.8 vs 320.0 ± 78.5 minutes; p = 0.031) and telemedicine (242.0 ± 75.2 vs 319.0 ± 83.8 minutes; p = 0.007).
Conclusion We found that long-distance transfer did not impair surgical outcomes in AADA patients, and both helicopter transfer and cloud-type telemedicine system could contribute to the reduction of diagnosis-to-operation time in the large Hokkaido area. Further studies are mandatory to investigate if both the systems will improve clinical outcomes.