bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social and clinical risk factors associated with hospitalized COVID-19 patients in Brussels’s deprived and multiethnic areas
Authors: Racape Judith , Noel Anne-Cecile , Lurel Jerome , Dauby Nicolas , Coppieters Yves , Goffard Jean-Christophe , Rea Andrea 
Published: July 2023

BackgroundIn Belgium, the Brussels-Capital region was severely affected by the COVID-19 epidemic. Various hypotheses were mentioned in order to explain Brussels’ excess disease spreading and mortality rate, but socioeconomic risk factors are increasingly recognized. This study’s objective was to analyze clinical and social profiles of patients hospitalized for COVID-19, by nationality groups, in two hospitals located in Brussels’s deprived and multiethnic areas.MethodsData covered hospitalized COVID-19 patients from two Brussels hospitals (n = 787) between the 1st of March 2020 and the 31st of June 2020. Social data was collected using hospital records, and clinical data was extracted from hospitals’ COVID-19 databases. Multivariable logistic regression models were used to estimate the odds ratios (OR) of the association between two outcomes (Intensive Care Unit admission and mortality) and risk factors (social and clinical).ResultsPatients from Sub-Saharan Africa were younger, had a higher prevalence of obesity, lacked health insurance, and had the highest proportion of Intensive Care Unit (ICU) admission (27.7%) but the lowest mortality rates than other nationality groups. Patients from North Africa had a higher prevalence of diabetes compared to other nationality groups and a high proportion of European patients came from nursing homes. Patients deprived of health insurance had a higher risk of ICU admission compared to those who had insurance (OR IC95%; 1,9 1.1–3.6, p = 0.03). Other risk factors as sex and obesity were significantly associated to ICU admission and, age and hypertension were significantly associated to mortality.ConclusionSocial and clinical profile of the patients differs between the nationality groups, and some risk factors for Intensive Care Unit admission and mortality were linked to more patients’ precarious situation as the availability of health insurance. This study underlines the role of selected social health determinants and the importance of routinely collecting social along with clinical data.
Diabetes self-management education interventions and self-management in low-resource settings; a mixed methods study
Authors: Lamptey Roberta , Amoakoh-Coleman Mary , Djobalar Babbel , Grobbee Diederick E. , Adjei George Obeng , Klipstein-Grobusch Kerstin 
Published: July 2023

IntroductionDiabetes is largely a self-managed disease; thus, care outcomes are closely linked to self-management behaviours. Structured self-management education (DSME) interventions are, however, largely unavailable in Africa.AimWe sought to characterise DSME interventions in two urban low-resource primary settings; and to explore diabetes self-management knowledge and behaviours, of persons living with diabetes (PLD).Research design and methodsA convergent parallel mixed-methods study was conducted between January and February 2021 in Accra, Ghana. The sampling methods used for selecting participants were total enumeration, consecutive sampling, purposive and judgemental sampling. Multivariable regression models were used to study the association between diabetes self-management knowledge and behaviours. We employed inductive content analysis of informants’ experiences and context, to complement the quantitative findings.ResultsIn total, 425 PLD (70.1% (n = 298) females, mean age 58 years (SD 12), with a mean blood glucose of 9.4 mmol/l (SD 6.4)) participated in the quantitative study. Two managers, five professionals, two diabetes experts and 16 PLD participated in in-depth interviews. Finally, 24 PLD were involved in four focus group discussions. The median diabetes self-management knowledge score was 40% ((IQR 20–60). For every one unit increase in diabetes self-management knowledge, there were corresponding increases in the diet (5%;[95% CI: 2%-9%,p<0.05]), exercise (5%; [95% CI:2%-8%,p<0.05]) and glucose monitoring (4%;[95% CI:2%-5%,p<0.05]) domains of the diabetes self-care activities scale respectively. The DSME interventions studied, were unstructured and limited by resources. Financial constraints, conflicting messages, beliefs, and stigma were the themes underpinning self-management behaviour.ConclusionsThe DSME interventions studied were under-resourced, and unstructured. Diabetes self-management knowledge though limited, was associated with self-management behaviour. DSME interventions in low resource settings should be culturally tailored and should incorporate sessions on mitigating financial constraints. Future studies should focus on creating structured DSME interventions suited to resource-constrained settings.
Dynamic susceptibility contrast perfusion-weighted and diffusion-weighted magnetic resonance imaging findings in pilocytic astrocytoma and H3.3 and H3.1 variant diffuse midline glioma, H3K27-altered
Authors: Kurokawa Ryo , Kurokawa Mariko , Baba Akira , Kim John , Srinivasan Ashok , Moritani Toshio 
Published: July 2023

Objective
This study compared the dynamic susceptibility contrast (DSC) magnetic resonance imaging parameters and apparent diffusion coefficient (ADC) between pilocytic astrocytoma (PA) and diffuse midline glioma, H3K27-altered (DMG) variants.

Methods
The normalized relative cerebral blood volume (nrCBV), normalized relative flow (nrCBF), percentile signal recovery (PSR), and normalized mean ADC (nADCmean) of 23 patients with midline PAs (median age, 13 years [range, 1–71 years]; 13 female patients) and 40 patients with DMG (8.5 years [1–35 years]; 19 female patients), including 35 patients with H3.3- and five patients with H3.1-mutant tumors, treated between January 2016 and May 2022 were statistically compared.

Results
DMG had a significantly lower nADCmean (median: 1.48 vs. 1.96; p = 0.00075) and lower PSR (0.97 vs. 1.23, p = 0.13) but higher nrCBV and nrCBF (1.66 vs. 1.17, p = 0.058, respectively, and 1.87 vs. 1.19, p = 0.028, respectively) than PA. The H3.3 variant had a lower nADCmean than the H3.1 variant (1.46 vs. 1.80, p = 0.10).

Conclusion
DMG had lower ADC and PSR and higher rCBV and rCBF than PA. The H3.3 variant had a lower ADC than the H3.1 variant. Recognizing the differences and similarities in the DSC parameters and ADC between these tumors may help presurgical diagnosis.
Investigation into relationships between design parameters and mechanical properties of 3D printed PCL/nHAp bone scaffolds
Authors: Yazdanpanah Zahra , Kumar Sharma Nitin , Zimmerling Amanda , Cooper David M. L. , Johnston James D. , Chen Xiongbiao 
Published: July 2023

Background
Scaffolds are of great importance in tissue engineering applications as they provide a mechanically supportive environment for cellular activity, which is particularly necessary for hard tissues such as bone. Notably, the mechanical properties of a scaffold vary with differing design parameters such as those related to scaffold height and internal structure. Thus, the present study aimed to explore the relationship between design parameters and mechanical properties of composite polycaprolactone (PCL) and nano-hydroxyapatite (nHAp) scaffolds fabricated by three-dimensional (3D) printing.

Methods
We designed and printed scaffolds with different internal structures (lattice and staggered) and varying heights (4, 6, 8 and 10 layers), and consistent porosity (50%) for the purpose of comparison. Then, we examined the scaffold microstructure (pore size and penetration between layers) using scanning electron microscopy (SEM) and mechanical properties (elastic modulus and yield strength) using compressive testing.

Results
Our results illustrated that the microstructural parameters were related to scaffold design. At higher heights, pore size increased while penetration between layers decreased; thus, mechanical properties were affected. Results of mechanical testing demonstrated that for lattice scaffolds, elastic modulus was similar for 6 vs 4, and 8 vs 4 layers but ~33% lower for 10 layers vs 4 layers. Similarly, yield strength was comparable for 6 vs 4, and 8 vs 4 layers but ~27% lower for 10 layers vs 4 layers. With staggered scaffolds, when compared to 4-layer results, elastic modulus was similar for 6 layers but was ~43% lower for 8 layers and ~38% lower for 10 layers. Staggered scaffolds had ~38%, ~51%, and ~76% lower yield strength when the number of layers were increased from 4 to 6, 8, and 10 layers, respectively. When comparing lattice and staggered scaffolds with the same layer number, elastic modulus was similar, apart from 8-layer scaffolds where the staggered design was ~42% lower than lattice. Yield strength was similar between 4-layer staggered and lattice scaffolds, while staggered scaffolds with 6, 8, and 10 number of layers showed ~43%, ~45%, ~68% lower strength, respectively, than those found in lattice scaffolds with the same layer numbers.

Conclusions
Mechanical properties of 3D printed scaffolds depended on scaffold height for both lattice and staggered internal structures. Staggered scaffolds had lower mechanical properties than the lattice scaffolds with the same height and were more sensitive to the change in scaffold height. Taken together, lattice scaffolds demonstrated the advantages of more stable mechanical properties over staggered scaffolds. Also, scaffolds with lower height were more promising in terms of mechanical properties compared to scaffolds with greater height.
Standard diagnostics with and without urine-based lipoarabinomannan testing for tuberculosis disease in HIV-infected patients in a high-burden setting–A cost-effectiveness analysis
Authors: Fekadu Ginenus , Wang Yingcheng , You Joyce H. S. 
Published: July 2023

Background
Recent clinical findings reported the reduced mortality associated with treatment guided by sputum-based molecular test with urine-based lipoarabinomannan (LAM) assay for tuberculosis (TB) disease in HIV-infected individuals. We aimed to evaluate the cost-effectiveness of sputum-based Xpert tests with and without urine-based LAM assays among HIV-infected individuals with signs and symptoms of TB disease (TBD) from the perspective of South African healthcare providers.

Methods
A one-year decision-analytic model was constructed to simulate TB-related outcomes of 7 strategies: Sputum smear microscope (SSM), Xpert, Xpert Ultra, Xpert with AlereLAM, Xpert Ultra with AlereLAM, Xpert with FujiLAM, and Xpert Ultra with FujiLAM, in a hypothetical cohort of adult HIV-infected individuals with signs and symptoms of TB. The model outcomes were TB-related direct medical cost, mortality, early treatment, disability-adjusted life-years (DALYs) and incremental cost per DALY averted (ICER). The model inputs were retrieved from literature and public data. Base-case analysis and sensitivity analysis were conducted.

Results
In the base-case analysis, the Xpert Ultra with FujiLAM strategy showed the highest incidence of early treatment (267.7 per 1000 tested) and lowest mortality (29.0 per 1000 tested), with ICER = 676.9 USD/DALY averted. Probabilistic sensitivity analysis of 10,000 Monte Carlo simulations showed the cost-effective probability of Xpert Ultra with FujiLAM was the highest of all 7 strategies at the willingness-to-pay (WTP) threshold >202USD/DALY averted.

Conclusion
Standard sputum-based TB diagnostic Xpert Ultra with urine-based FujiLAM for TBD testing in HIV-infected individuals appears to be the preferred cost-effective strategy from the perspective of the health service provider of South Africa.
Building element recognition with MTL-AINet considering view perspectives
Authors: Zhang Rongchun , Jing Meiru , Lu Guanming , Yi Xuefeng , Shi Shang , Huang Yi , Liu Lanfa 
Published: July 2023

Abstract
The reconstruction and analysis of building models are crucial for the construction of smart cities. A refined building model can provide a reliable data support for data analysis and intelligent management of smart cities. The colors, textures, and geometric forms of building elements, such as building outlines, doors, windows, roof skylights, roof ridges, and advertisements, are diverse; therefore, it is challenging to accurately identify the various details of buildings. This article proposes the Multi-Task Learning AINet method that considers features such as color, texture, direction, and roll angle for building element recognition. The AINet is used as the basis function; the semantic projection map of color and texture, and direction and roll angle is used for multi-task learning, and the complex building facade is divided into similar semantic patches. Thereafter, the multi-semantic features are combined using hierarchical clustering with a region adjacency graph and the nearest neighbor graph to achieve an accurate recognition of building elements. The experimental results show that the proposed method has a higher accuracy for building detailed edges and can accurately extract detailed elements.
hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/β-catenin signaling pathway
Authors: Du Jun , Zhuo Yingquan , Sun Xu , Nie Meilan , Yang Jiafei , Luo Xi , Gu Huajian 
Published: July 2023

Abstract
Circular RNA has been reported to play a key role in neuroblastoma (NB); however, the role of circ_0000285 in NB remains unclear. The aim of this study was to elucidate the role of circ_0000285 in NB. We studied the expression patterns of miR-582-3p and circ_0000285 in NB tissues and cells using real-time quantitative polymerase chain reaction. The expression of proteins associated with apoptosis (Bax and Bcl-2) and the proteins associated with Wnt/β-catenin (Wnt, p-Gsk-3β, Gsk-3β, β-catenin, and C-myc) were quantified by western blotting. In vivo animal models were prepared for the functional verification of circ_0000285 on tumor growth. The potential binding of circ_0000285 to miR-582-3p was ascertained using dual-luciferase reporter and RNA-binding protein immunoprecipitation experiments. Noticeable upregulation of circ_0000285 expression was observed in NB tumor samples and cell lines. In vivo and in vitro experiments indicated that the absence of circ_0000285 repressed NB cell proliferation and migration, provoked apoptosis, and impaired the activity of Wnt/β-catenin signaling. miR-582-3p is targeted by circ_0000285 and is poorly expressed in NB cells. The additional repression of miR-582-3p in NB cells after circ_0000285 silencing largely recovered circ_0000285 silencing-suppressed NB cell proliferation and migration and enhanced apoptosis. The absence of miR-582-3p restored Wnt/β-catenin signaling activity impaired by the knockdown of circ_0000285. circ_0000285 functions as an miR-582-3p sponge to strengthen Wnt/β-catenin signaling activity, thus exacerbating NB development.
Crystal structure of (E)-2-amino-N′-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)benzohydrazide – dimethylformamide – water (1/1/2), C15H16N4O3·C3H7NO·2H2O
Authors: Wang Xue , Han Jie , Zheng Jing , Yuan Xiao-Jing , Xiong Ying 
Published: July 2023

Abstract
C18H27N5O6, monoclinic, P21/n (no. 14), a = 11.6588(12) Å, b = 7.0645(6) Å, c = 25.700(3) Å, β = 94.899(3)°, V = 2109.0(4) Å3, Z = 4, R
gt(F) = 0.0630, wR
ref(F
2) = 0.1632, T = 273 K.
Crystal structure of 10-methoxy-7,11b,12,13-tetrahydro-6H-pyrazino [2′,3′:5,6]pyrazino[2,1-a]isoquinoline, C15H16N4O
Authors: Wang Zi Wei , Yu Yu 
Published: July 2023

Abstract
C15H16N4O, monoclinic, P21/c (no. 14), a = 10.3021(8) Å, b = 15.7835(13) Å, c = 8.3052(7) Å, β =

90.894

(
7
)

∘

$90.894{\left(7\right)}^{\circ }$

, V = 1350.29(19)
Scopus-Based Study of Sustainability in the Syrian Higher Education Focusing on the Largest University
Authors: Al-Raeei Marwan 
Published: July 2023

Abstract
Achieving an effective sustainable developmental policy is considered a primary goal in a large number of institutions around the world. The application of this policy in universities is reflected throughout the country, especially in developing and low-income countries. This research aims to analyse the sustainability policies adopted at Damascus University during the past 5 years of the Syrian crisis through several factors, with a focus on the analysis based on the SciVal and Scopus databases. We consider Damascus University as an example of an institution of a developing country. We use the method of extracting and analysing the data of the 16 sustainable development goals (SDGs) of Damascus University within Scopus. Based on Scopus and SciVal data, we find that Damascus University made a significant leap in the number of its research related to sustainable development in the year 2022, as these research studies constituted 46.0% of all published, abstracted, and indexed research studies in Scopus by Damascus University researchers. Also, by analysing the citation data which the SDG documents have received, we find that the citations resulted from these documents represent about 53% of the total citation of the university during the same time.
From (semi-)oppositional to non-oppositional middles: the case of Spanishreír(se)
Authors: de Benito Moreno Carlota 
Published: July 2023

AbstractThis paper seeks to explore the possibility that Spanish intransitive verbs showing middle marking with no associated change of valency are a source of non-oppositional middle verbs. In order to do so, a study is conducted of the historical evolution of the middle-marked Spanish verbreír(se)‘to laugh’ as well as other semantically related verbs (such asalegrar(se)‘to be happy, pleased’,regocijarse‘to rejoice’ andburlar(se),mofar(se),escarnecer(se)‘to mock, to ridicule, to make fun of’), where the presence of the middle marker is associated with a valency-reducing diathesis.
Middle voice in Bantu: in- and detransitivizing morphology in Kagulu
Authors: Dom Sebastian , Bar-el Leora , Kanijo Ponsiano Sawaka , Petzell Malin 
Published: July 2023

Abstract
This paper explores the middle voice in Kagulu, a Bantu language of Tanzania. Although not traditionally recognized in Bantu languages, recent research has asserted that middle voice is attested in some Bantu languages. We propose that of eight affixes that might be considered middle markers, Kagulu has two affixes that are part of the middle voice system, each one coding two different detransitivizing voices. We argue that, from a diachronic viewpoint, the underdeveloped voice syncretism of Kagulu’s middle markers is the result of competing morphology and minimal functional innovations towards voice syncretism in the derivational system of Kagulu.
Evidence against unidirectionality in the emergence of middle voice systems
Authors: Inglese Guglielmo , Verstraete Jean-Christophe 
Published: July 2023

AbstractMiddle voice systems are characterized by the distribution of a middle marker over two macro-classes of verbs: oppositional and non-oppositional verbs. In diachronic studies, it has been proposed that the historical link between the two groups is unidirectional, with middle marking spreading from oppositional to non-oppositional verbs. In this paper, we challenge this assumption and discuss two case studies, one from Anatolian and one from Paman languages that show the opposite development, that is, from non-oppositional to oppositional. In both cases, we argue, constructions that originally had a lexically determined distribution develop grammatical functions connected with valency reduction.
Second-Century CE Lexicography: Genre or a Literary Current of Language, Politics, and Social Dynamics?
Authors: Bozia Eleni 
Published: July 2023

Abstract
This paper discusses Greek and Latin lexicography and its literary and socio-cultural manifestations during the second century CE. I argue that Imperial lexicography had an actualized social existence that went beyond the recording of lemmata. More specifically, I maintain that lexicographers used their works not only as technical records and manuals but to legitimize (or not) linguistic forms alongside social phenomena. Additionally, other authors of the High Empire modulated the essence of linguistic idiosyncrasies and incorporated them into literary genres beyond lexica; they thus considered issues of identity and belonging against the backdrop of lexical propriety. This contribution closely studies Moeris and Phrynichus as well as Lucian and Aulus Gellius to show how lexicography transcended literary genre to become a modus dicendi vivendique.
Claretus And the City: The

Glossarius, Its Latin Neologisms and Its Reception in Municipal Administrative Texts
Authors: Nývlt Pavel 
Published: July 2023

Abstract
The influence of Medieval Latin dictionaries on other genres of Medieval Latin literature was limited by two factors: their tendency to preserve ancient hapaxes that appeared nowhere else, and their creativity, resulting in the formation of words no other writer used. A prime example of the latter attitude are the poems written by a 14th-century Czech lexicographer known as Claretus. After a brief outline of the structure of his last and longest versed dictionary, the Glossarius, Claretus’ knack for word-formation is illustrated by several hundred nouns denoting activities, actions, and persons with selected suffixes. Documents created by municipal administration in the 14th and 15th centuries also contain a goodly number of neologisms, even hapax legomena, and verbal overlaps alone are by no means sufficient to prove their authors were acquainted with Claretus’ poems. Nevertheless, I argue that Claretus’ influence is detectable in a handful of administrative texts from medieval Bohemia.
Effect of ethanol and sodium chloride on the physio-chemical properties of Montelukast sodium and its interaction with DNA
Authors: Khan Abbas , Shahid Kashif , Khan Sumayya , Humayun Muhammad , Bououdina Mohamed , Rehman Noor , Sultana Sabiha , Munawar Khurram Shahzad 
Published: July 2023

Abstract
In drug development, it is very important to study the physicochemical properties of drugs under various solution conditions in order to understand their mechanism of action and their interactions with bioactive compounds. In this regard, this study attempts to elucidate the effects of co-solvent and co-solute on the physicochemical properties of Montelukast sodium and its possible interactions with deoxyribonucleic acid (DNA). The physicochemical, volumetric and thermodynamic properties of Montelukast sodium were determined by various measurements such as density, viscosity and surface tension. Most of these measured parameters responded differently when ethanol (co-solvent) and sodium chloride (co-solvent) were added to the drug solution, and/or when the concentration and temperature of the drug solution were changed. Various solution properties such as flow behavior, surface activity and association behavior of Montelukast sodium were also affected by the addition of DNA. UV–Vis spectroscopy was also used to better understand the qualitative and quantitative strength of DNA-drug interactions in water. Using UV–Visible analysis, the Montelukast DNA binding constant (Kb) was determined to be 6.861 × 103 (L Mol−1). Physicochemical and spectroscopic results confirmed that there may be physicochemical type interactions between the drug and DNA. It is also proposed that hydrogen bonding can occur between the oxygen and hydrogen atoms of the Montelukast sodium and the hydrogen, oxygen and nitrogen atoms of the DNA molecule.