bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiative association of P+(3P) and O(3P) for the PO+ formation
Authors: Qin Zhi , Hu Peigen , Li Jing , Liu Linhua 
Published: May 2023

ABSTRACT
Phosphorus (P) is essential for the development of life since it is a fundamental element in many important biological molecules. Due to its biogenic importance, many astrochemists have begun to investigate the possibility of the phosphorus-bearing species formed in interstellar environments. Radiative association (RA) is a possible way for the formation of the phosphorus monoxide ion (PO+) in interstellar and related environments. Laboratory measurements are almost impossible to carry out, so theoretical calculations are essential for investigating such formation mechanism of PO+. The quantum mechanical method is used to obtain its cross sections and rate coefficients. Thirty contributing processes for the computation of the total rate coefficient are considered, including 22 transition dipole processes and eight permanent dipole processes. The total rate coefficient varies little over the entire temperature range of 1–10 000 K and its magnitude is of the order of (4–8) × 10−17 cm3 s−1. The 2 1Σ+ → X 1Σ+ transition process dominates the formation of PO+ by RA over the entire temperature range considered here. The C 1Π → X 1Σ+ and 2 3Σ+ → a 3Σ+ are also relatively important, but their rate coefficients are about an order of magnitude smaller than that of the 2 1Σ+ → X 1Σ+ channel. The obtained cross sections and rate coefficient can be used to model the P astrochemistry in the interstellar medium.
Redshift evolution of the dark matter haloes shapes
Authors: Cataldi P , Pedrosa S E , Tissera P B , Artale M C , Padilla N D , Dominguez-Tenreiro R , Bignone L , Gonzalez R , Pellizza L J 
Published: May 2023

ABSTRACT
In this work, we aim at investigating the morphology evolution of Milky Way mass-like dark matter haloes selected from the cielo and IllustrisTNG projects. The connection between halo shapes and their environment has been studied in previous works at z = 0 but their connection remains yet to be fully understood. We focus on the evolution across cosmic time of the halo shapes and the relation with the infalling material, using hydrodynamical simulations. Our findings show that haloes tend to be more triaxial at earlier times as a consequence of stronger accretion in the direction of the filaments. As the haloes evolve towards a dominant isotropic accretion mode and relaxation, their shape at 20 per cent of the virial radius becomes more spherical. In agreement with previous results, baryons have an important effect within the inner regions of the haloes, driving them from triaxial to rounder shapes. We also find a correlation between the strength of the quadrupole infalling mode and the degree of ellipticity of the haloes: as the filament strength decreases steadily with redshift, the haloes became more spherical and less elliptical.
Long-term relationships between the abundance of pest molluscs and weather in agricultural fields in South Australia
Authors: Baker Geoff H 
Published: May 2023

ABSTRACT
Invasive snails, Cernuella virgata, Theba pisana and Cochlicella acuta, infest grain crops prior to harvest in early summer in southern Australia. They breed in autumn–early winter and peak in abundance in spring following the recruitment of young snails. Long-term studies (20 years) were established on three farms in South Australia (two practicing pasture–cereal rotations and one continuous cropping) to better understand the role of prevailing weather in driving the population dynamics of the three snail species and to develop predictive models that might assist farmers and off-farm grain handlers to anticipate future peaks in snail abundance and tailor their management practices accordingly. The three species are asynchronous in their population dynamics; they peak in numbers in different years. The abundance of C. virgata in late spring (preharvest) was most closely associated with, and could be broadly predicted by, the previous autumn to spring rainfall, but no significant associations were found between the rainfall and the abundance of C. acuta and T. pisana. Local air temperatures had little apparent association with the abundance of all three species. Broader scale weather, exemplified by the El Niño Southern Oscillation Index, was only occasionally, and weakly, related to the spring abundance of C. virgata.
Formal Excess in the Opening Movement of Fanny Hensel’s String Quartet in E♭ Major (1834)
Authors: Kim Catrina S 
Published: May 2023

Abstract
This article analyzes the Adagio opening movement of Fanny Hensel’s sole string quartet by reading the ways in which it dialogues with several genres: the increasingly independent early nineteenth-century slow introduction; the slow first movement; eighteenth- and early nineteenth-century sonata form; and the fantasia. I build this generic context by considering the historical development of the slow introduction and drawing attention to such overlapping identities in two cello sonata movements by Ludwig van Beethoven and in Hensel’s Sonata o Fantasia in G minor for Piano and Cello (1829).
A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium
Authors: Vindry Caroline , Guillin Olivia , Wolff Philippe , Marie Paul , Mortreux Franck , Mangeot Philippe E , Ohlmann Théophile , Chavatte Laurent 
Published: May 2023

Abstract
The selenocysteine (Sec) tRNA (tRNA[Ser]Sec) governs Sec insertion into selenoproteins by the recoding of a UGA codon, typically used as a stop codon. A homozygous point mutation (C65G) in the human tRNA[Ser]Sec acceptor arm has been reported by two independent groups and was associated with symptoms such as thyroid dysfunction and low blood selenium levels; however, the extent of altered selenoprotein synthesis resulting from this mutation has yet to be comprehensively investigated. In this study, we used CRISPR/Cas9 technology to engineer homozygous and heterozygous mutant human cells, which we then compared with the parental cell lines. This C65G mutation affected many aspects of tRNA[Ser]Sec integrity and activity. Firstly, the expression level of tRNA[Ser]Sec was significantly reduced due to an altered recruitment of RNA polymerase III at the promoter. Secondly, selenoprotein expression was strongly altered, but, more surprisingly, it was no longer sensitive to selenium supplementation. Mass spectrometry analyses revealed a tRNA isoform with unmodified wobble nucleotide U34 in mutant cells that correlated with reduced UGA recoding activities. Overall, this study demonstrates the pleiotropic effect of a single C65G mutation on both tRNA phenotype and selenoproteome expression.
Contact Days Associated With Cancer Treatments in the CCTG LY.12 Trial
Authors: Gupta Arjun , Hay Annette E , Crump Michael , Djurfeldt Marina S , Zhu Liting , Cheung Matthew C , Shepherd Lois E , Chen Bingshu E , Booth Christopher M 
Published: May 2023

Abstract

Background
When cancer treatments have similar oncologic outcomes, the number of days with in-person healthcare contact (“”contact days’’) can help contextualize expected time use with each treatment. We assessed contact days in a completed randomized clinical trial.

Patients and Methods
We conducted a secondary analysis of the CCTG LY.12 RCT that evaluated 2-3 cycles of gemcitabine, dexamethasone, and cisplatin (GDP) vs. dexamethasone, cytarabine, and cisplatin (DHAP) in 619 patients with relapsed/refractory lymphoma prior to stem cell transplant. Primary analyses reported similar response rates and survival. We calculated patient-level “contact days” by analyzing trial forms. The study period was from assignment to progression or transplant. Days without healthcare contact were considered “home days’’. We compared measures of contact days across arms.

Results
The study period was longer in the GDP arm (median 50, vs. 47 days, P = .007). Contact days were comparable in both arms (median 18 vs 19, P = 0.79), but home days were higher in the GDP arm (median 33 vs 28, P &lt; .001). The proportion of contact days was lower in the GDP arm (34%, vs. 38%, P = .009). The GDP arm experienced more contact days related to planned outpatient chemotherapy (median, 10 vs. 8 days), but the DHAP arm experienced many more inpatient contact days (median, 11 vs. 0 days).

Conclusions
Measures of time use, such as contact days, can be extracted from RCTs. In LY.12, despite comparable oncologic outcomes, GDP was associated with fewer contact days. Such information can guide decision-making for patients with hematological cancers, who already face significant healthcare contact.
Investigating association between gut microbiota and sarcopenia-related traits: a Mendelian randomization study
Authors: Zhao Jiaxi , Liang Rui , Song Quhong , Song Shiyu , Yue Jirong , Wu Chenkai 
Published: May 2023

Abstract

Background
Observational studies have indicated a potential link between gut microbiota and sarcopenia. However, the underlying mechanisms and a causal relationship have not been established. Thus, the objective of this study is to examine the possible causal association between gut microbiota and sarcopenia-related traits, including low hand-grip strength and appendicular lean mass (ALM), to shed light on the gut–muscle axis.

Methods
To investigate the potential impact of gut microbiota on low hand-grip strength and ALM, we utilized a two-sample Mendelian randomization (MR) approach. Summary statistics were obtained from genome-wide association studies of gut microbiota, low hand-grip strength, and ALM. The primary MR analysis employed the random-effects inverse-variance weighted (IVW) method. To assess the robustness, we conducted sensitivity analyses using the MR pleiotropy residual sum and outlier (MR-PRESSO) test to detect and correct for horizontal pleiotropy, as well as the MR-Egger intercept test and leave-one-out analysis.

Results
Alcaligenaceae, Family XIII, and Paraprevotella were positively associated with the risk of low hand-grip strength (P-values &lt; 0.05). Streptococcaceae were negatively associated with low hand-grip strength (P-values &lt; 0.05). Eight bacterial taxa (Actinomycetales, Actinomycetaceae, Bacteroidaceae, Porphyromonadaceae, Prevotellaceae, Bacteroides, Marvinbryantia, and Phascolarctobacterium) were associated with a higher risk of ALM (P-values &lt; 0.05). Eubacterium fissicatena group was negatively associated with ALM (P-values &lt; 0.05).

Conclusion
We found several gut microbiota components causally associated with sarcopenia-related traits. Our findings provided insights into novel strategies for the prevention and treatment of sarcopenia through the regulation of the gut microbiota, contributing to a better understanding of the gut–muscle axis.
High-resolution genome mapping and functional dissection of chlorogenic acid production in Lonicera maackii
Authors: Li Ruili , Xu Jing , Qi Zengxing , Zhao Shiwei , Zhao Ran , Ge Yanrui , Li Ruofan , Kong Xiuya , Wu Zhenying , Zhang Xi , He Qizouhong , Zhang Yan , Liu Ping-Li , Zhu Lei , Mao Jian-Feng , Fu Chunxiang , Komis George , Grünhofer Paul , Schreiber Lukas , Lin Jinxing 
Published: May 2023

Abstract
Amur honeysuckle (Lonicera maackii) is a widely used medicinal plant of the Caprifoliaceae family that produces chlorogenic acid. Research on this plant mainly focuses on its ornamental value and medicinal compounds, but a reference genome sequence and molecular resources for accelerated breeding are currently lacking. Herein, nanopore sequencing and high-throughput chromosome conformation capture (Hi-C) allowed a chromosome-level genome assembly of L. maackii (2n = 18). A global view of the gene regulatory network involved in the biosynthesis of chlorogenic acid and the dynamics of fruit coloration in L. maackii was established through metabolite profiling and transcriptome analyses. Moreover, we identified the genes encoding hydroxycinnamoyl-CoA quinate transferase (LmHQT) and hydroxycinnamoyl-CoA shikimic/quinate transferase (LmHCT), which localized to the cytosol and nucleus. Heterologous overexpression of these genes in Nicotiana benthamiana leaves resulted in elevated chlorogenic acid contents. Importantly, HPLC analyses revealed that LmHCT and LmHQTs recombinant proteins modulate the accumulation of chlorogenic acid (CGA) using quinic acid and caffeoyl CoA as substrates, highlighting the importance of LmHQT and LmHCT in CGA biosynthesis. These results confirmed that LmHQTs and LmHCT catalyze the biosynthesis of CGA in vitro. The genomic data presented in this study will offer a valuable resource for the elucidation of CGA biosynthesis and facilitating selective molecular breeding.
The Surprising Positive Asymmetry in the Impact of Organizational Justice on Police Outcomes
Authors: Peacock Robert P , Ivković Sanja Kutnjak , Wu Yuning , Sun Ivan , Vinogradac Marijan , Vinogradac Valentina Pavlović 
Published: May 2023

Abstract
As police organizational justice research continues to mature, this article examines whether an asymmetry exists between positive and negative supervisory experiences on officer perceptions of police performance. The study builds on new theoretical developments in organizational justice that argues for better capturing the independent roles of just and unjust supervisory behaviour. A generally held, but untested, view in the organizational behaviour literature suggests a negative bias: perceptions of unjust supervisors affect employee outcomes more than those viewed as procedurally just. This cross-national test of the impact of supervisory procedural justice finds the existence of a strong positive bias across officer attitudes on police-citizen interactions and rule compliance. Specifically, officer perceptions of just supervisors have a greater influence on officer attitudes toward procedural justice, procedural injustice, and rule compliance in their interactions with the public.
Sustained cell-mediated but not humoral responses in rituximab-treated rheumatic patients after vaccination against SARS-CoV-2
Authors: Thomas Κonstantinos , Grigoropoulos Ioannis , Alexopoulou Panagiota , Karofylakis Emmanouil , Galani Irene , Papadopoulou Kyriaki Korina , Tsiavou Anastasia , Ntourou Aliki , Mavrou Eleftheria , Qevani Irina , Katsimbri Pelagia , Koutsianas Christos , Mavrea Evgenia , Vassilopoulos Dimitrios , Pournaras Spyros , Tsiodras Sotirios , Boumpas Dimitrios , Antoniadou Anastasia 
Published: May 2023

Abstract

Objectives
B-cell depleting monoclonal antibodies are associated with increased COVID-19 severity and impaired immune response to vaccination. We aimed to assess the humoral and cell mediated (CMI) immune response after SARS-CoV-2 vaccination in rituximab (RTX)-treated rheumatic patients.

Methods
Serum and whole blood samples were collected from RTX-treated rheumatic patients 3–6 months after last vaccination against SARS-CoV-2. Serum was tested by ELISA for quantitative detection of anti-spike SARS-CoV-2 IgG. Cell-mediated variant-specific SARS-CoV-2 immunity (CMI) was assessed by interferon-γ release assay Covi-FERON FIA. Patients were interviewed for breakthrough COVID-19 infection (BTI) 3 months post sampling.

Results
Sixty patients were studied after a median (IQR) of 179 (117–221.5) days from last vaccine to sampling. Forty (66.7%) patients had positive Covi-FERON and 23 (38.3%) had detectable anti-spike IgG. Covi-FERON positive patients had lower median RTX cumulative dose [6 (4–10.75) vs 11 (6.75–14.75) grams, (P = 0.019)]. Patients with positive anti-spike IgG had received fewer RTX cycles [2 (2–4) vs 6 (4–8), P = 0.002] and cumulative dose [4 (3–7) vs 10 (6.25–13) grams, P = 0.002] and had shorter time from last vaccination to sampling [140 (76–199) vs 192 (128–230) days, P = 0.047]. Thirty-seven percent were positive only for Covi-FERON and 7% only for anti-spike IgG. Twenty (33.3%) BTI occurred post sampling, exclusively during Omicron variant predominance. The proportion of patients with CMI response against Delta variant was lower in patients who experienced BTI (25% vs 55%, P = 0.03).

Conclusions
Four out of ten RTX-treated vaccinated patients show lasting cell-mediated immune response despite undetectable anti-spike antibodies. Cumulative RTX dose affects both humoral and cell-mediated responses to SARS-CoV-2 vaccines. Cell-mediated immune responses call for attention as a vaccine efficacy marker against SARS-CoV-2.
Belimumab and antimalarials combined against renal flares in patients treated for extra-renal systemic lupus erythematosus: results from 4 phase III clinical trials
Authors: Gomez Alvaro , Jägerback Sandra , Sjöwall Christopher , Parodis Ioannis 
Published: May 2023

Abstract

Objectives
To determine the effect of antimalarial agents (AMA) and different doses and pharmaceutical forms of belimumab on preventing renal flares in patients with SLE treated for extra-renal disease.

Methods
We pooled data from the BLISS-52, BLISS-76, BLISS-SC and BLISS-Northeast Asia trials of belimumab (n = 3225), that included patients with active SLE yet no severe ongoing nephritis. Participants were allocated to receive intravenous belimumab 1 mg/kg, intravenous belimumab 10 mg/kg, subcutaneous belimumab 200 mg, or placebo in addition to standard therapy. We estimated hazards of renal flare development throughout the study follow-up (52–76 weeks) using Cox regression analysis.

Results
In total, 192 patients developed a renal flare after a median of 197 days. Compared with placebo, the risk of renal flares was lower among patients receiving intravenous belimumab 10 mg/kg (HR: 0.62; 95% CI: 0.41, 0.92; P = 0.018) and intravenous belimumab 1 mg/kg (HR: 0.42; 95% CI: 0.22, 0.79; P = 0.007), while no significant association was found for subcutaneous belimumab 200 mg. AMA use yielded a lower hazard of renal flares (HR: 0.66; 95% CI: 0.55, 0.78; P &lt; 0.001). The protection conferred was enhanced when belimumab and AMA were co-administered; the lowest flare rate was observed for the combination intravenous belimumab 1 mg/kg and AMA (18.5 cases per 1000 person-years).

Conclusions
The protection conferred from belimumab against renal flare development in patients treated for extra-renal SLE appears enhanced when belimumab was administered along with AMA. The prominent effect of low-dose belimumab warrants investigation of the efficacy of intermediate belimumab doses.

Clinical trial identification
BLISS-52: NCT00424476; BLISS-76: NCT00410384; BLISS-SC: NCT01484496; BLISS-NEA: NCT01345253.
Effects of rainfall and temperature on background signal of radiation portal monitor
Authors: Sim Hayoung , Choi Hyosang , Baek Seungho , Seo Hee , Choi Hyeonjun , Kim Haneul , Jang Jaeho 
Published: May 2023

Abstract
For homeland security, radiation portal monitors (RPMs) have been widely used to detect illegal radioactive materials at seaports, airports, nuclear facilities and other highly secured establishments. In general, commercial RPMs are based on a large plastic (i.e. PVT-polyvinyl toluene) scintillator detector and the associated electronics. In order to detect radioactive materials passing through the RPM, the alarm criterion should be set according to the background level, which depends on the operating location due to not only composition differences in soil and rocks but also weather variation (i.e. rainfall and temperature). It is well known that RPM background signal level increases with rainfall and that the PVT signal depends on the temperature due to scintillation light yield variation. In this study, the background signal level of two commercial RPMs (models: 4525-3800 and 7000, Ludlum), both of which are installed and operated at the Incheon and Donghae ports in Korea, was analysed by reference to a 3-year database of minute-to-minute RPM background signals and a rainfall-and-temperature database provided by the Korea Meteorological Administration (KMA). In terms of rainfall, the variation of the background signal level was examined with reference to the amount of rainfall. The averaged variation in the background signal level, which was as high as ~20% as a function of the amount of rainfall, was found to be dependent on a region’s specific concentration of 222Rn in the atmosphere. In terms of temperature, the background signal level varied by ~4.7% within the temperature range of −5 to 30°C for the four studied sites (i.e. two sites per region for the Incheon and Donghae regions). Knowledge of the dependency of RPM background signal level on rainfall amount and temperature could be used to achieve more realistic estimation of the background radiation level for optimising commercial RPMs’ alarm criteria.
PyMCGPU-IR Monte Carlo code test for occupational dosimetry
Authors: Balcaza Víctor García , Bosman David Fernández , Badal Andreu , Von Barnekow Ariel , O’Connor Una , Camp Anna , López Joan Aranda , Ginjaume Mercè , Duch María Amor 
Published: May 2023

Abstract
PyMCGPU-IR is an innovative occupational dose monitoring tool for interventional radiology procedures. It reads the radiation data from the Radiation Dose Structured Report of the procedure and combines this information with the position of the monitored worker recorded using a 3D camera system. This information is used as an input file for the fast Monte Carlo radiation transport code MCGPU-IR in order to assess the organ doses, Hp(10) and Hp(0.07), as well as the effective dose. In this study, Hp(10) measurements of the first operator during an endovascular aortic aneurysm repair procedure and a coronary angiography using a ceiling suspended shield are compared to PyMCGPU-IR calculations. Differences in the two reported examples are found to be within 15%, which is considered as being very satisfactory. The study highlights the promising advantages of PyMCGPU-IR, although there are still several improvements that need to be implemented before its final clinical use.
Should the ISO slab phantom be used for calibrations in terms of the new ICRU 95 operational quantity personal dose?
Authors: Merza Victor , Hranitzky Christian , Steurer Andreas , Maringer Franz Josef 
Published: May 2023

Abstract
The applicability of the ISO slab phantom as calibration phantom for the new ICRU report 95 quantity personal dose should be legitimated by simulations and measurements of backscatter factors on the ISO slab phantom and, comparatively, on a human-like Alderson Rando phantom. An ionization chamber was used to determine backscatter factors for standardized X-ray spectra in the energy range of 16–250 keV and for gamma radiation of 137Cs (662 keV) and 60Co (1250 keV). For the validation of measurement results on the ISO slab, the results were compared with those obtained by means of Monte Carlo simulations using MCNP 6.2. Since the deviations of the backscatter factors on the ISO slab from those on the Alderson Rando were within ±5%, it could be concluded that it is not necessary to develop a new calibration phantom for the assessment of personal dose.