bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of space arrangement between anterior teeth on their retraction with clear aligners in first premolar extraction treatment: a finite element study
Authors: Cao Yuan , Wang Zhi-Wei , Chen Da , Liu Lu , Li Deng-Xin , Li Ni , Ying Si-Qi , Liu Xin , Jin Fang 
Published: September 2023

Abstract
Introduction
Clear aligner therapy has become increasingly popular in recent years, although it has encountered several difficulties in premolar extraction treatment. These difficulties include anterior dentition, lingual tipping and extrusion. The design of the present clinical scheme usually set a tiny space between the anterior teeth before retraction in order to obtain an ideal outcome. The objective of our research was to analyze the effect of the existing spaces during retraction.

Methods
Models including maxillary dentition without first premolars, maxilla, periodontal ligaments, gingiva, or aligners were constructed and imported to an ANSYS workbench. Five groups of models were created: without spaces and with 0.25, 0.50, 0.75 and 1.00 mm spaces between the anterior dentition. A 0.20 mm retraction step was applied to all the groups.

Results
As the spaces between the anterior dentition increased, the bowing effect of the aligner caused by the passive forces decreased gradually. Accordingly, the degree of extrusion of the anterior dentition was alleviated significantly, while sagittal movement was reduced. However, the overall movement tended to be a bodily displacement rather than tipping. Meanwhile, maximum Von Mises stress of the periodontal ligaments (PDLs) was markedly decreased.

Conclusion
These analyses indicate that spaces between the anterior dentition during anterior retraction are beneficial for decreasing the tendency for extrusion of the anterior dentition and require provision of anchorage. Appropriate spaces can be designed to lest the lingual tipping and extrusion effect of the anterior teeth while simultaneously reducing the maximum stresses on PDLs.
Calcium dynamics during the growth of Agaricus bisporus: implications for mushroom development and nutrition
Authors: Wu Juan , Wang Rui , Liu Xue , Ni Ying , Sun Hui , Deng Xiaonan , Wan Lingzhong , Liu Fangzhi , Tang Jun , Yu Junjie , Yan Xiaoming 
Published: September 2023

Abstract
Background
Agaricus bisporus (A. bisporus) is highly valued for its nutritional benefits and delicious taste, making it one of the most widely cultivated, highest yielding, and most consumed edible mushrooms worldwide. The yield and quality of A. bisporus were affected by its culture medium and environment. Among the culture base, the precise impact of calcium on A. bisporus cultivation and the dynamic changes in calcium concentration and chemical environment during the cultivation process remain unclear. This study aims to investigate the changes in calcium content and forms during the growth of A. bisporus and their implications for mushroom growth and nutrition.

Results
Through the analysis of samples collected during the composting phase, mycelial development phase, and A. bisporus harvesting phase, the role of calcium in the growth process of button mushrooms is revealed. During the composting phase, the calcium content remains relatively stable, suggesting a consistent calcium source in the compost. The fermentation process shows a significant decrease in carbon content and an increase in oxygen content, indicating the degradation and oxidation of organic matter. In the mycelial development phase, both the cover soil and compost experience a decrease in calcium content, with a more pronounced reduction observed in the covering soil, indicating its primary role as an energy source for enzymatic activity and metabolic processes of the mycelium. During the A. bisporus harvesting phase, the changes in calcium, carbon, and oxygen content become less prominent, indicating a stable state of fruiting bodies growth that no longer requires a significant supply of organic matter.

Conclusions
Analysis of calcium forms reveals the presence of different calcium compounds, likely influenced by soil calcium sources, microbial activities, and mushroom metabolic byproducts. Calcium plays a crucial regulatory role in the growth and quality of A. bisporus. This study provides valuable insights into the significance of calcium in A. bisporus growth and offers theoretical guidance for optimizing mushroom production and quality improvement.

Graphical Abstract
High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury
Authors: Xu Yonghao , Zhang Yu , Zhang Jie , Liang Weibo , Wang Ya , Zeng Zitao , Liang Zhenting , Ling Zhaoyi , Chen Yubiao , Deng Xiumei , Huang Yongbo , Liu Xiaoqing , Zhang Haibo , Li Yimin 
Published: September 2023

AbstractBackgroundMechanical ventilation may cause pulmonary hypertension in patients with acute lung injury (ALI), but the underlying mechanism remains elucidated.MethodsALI was induced in rabbits by a two-hit injury, i.e., hydrochloric acid aspiration followed by mechanical ventilation for 1 h. Rabbits were then ventilated with driving pressure of 10, 15, 20, or 25 cmH2O for 7 h. Clinicopathological parameters were measured at baseline and different timepoints of ventilation. RNA sequencing was conducted to identify the differentially expressed genes in high driving pressure ventilated lung tissue.ResultsThe two-hit injury induced ALI in rabbits was evidenced by dramatically decreased PaO2/FiO2in the ALI group compared with that in the control group (144.5 ± 23.8 mmHg vs. 391.6 ± 26.6 mmHg,P < 0.001). High driving pressure ventilation (20 and 25 cmH2O) significantly elevated the parameters of acute pulmonary hypertension at different timepoints compared with low driving pressure (10 and 15 cmH2O), along with significant increases in lung wet/dry ratios, total protein contents in bronchoalveolar lavage fluid, and lung injury scores. The high driving pressure groups showed more pronounced histopathological abnormalities in the lung compared with the low driving pressure groups, accompanied by significant increases in the cross-sectional areas of myocytes, right ventricular weight/body weight value, and Fulton’s index. Furthermore, the expression of the genes related to ferroptosis induction was generally upregulated in high driving pressure groups compared with those in low driving pressure groups.ConclusionsA rabbit model of ventilation-induced pulmonary hypertension in ALI was successfully established. Our results open a new research direction investigating the exact role of ferroptosis in ventilation-induced pulmonary hypertension in ALI.
On a large magmatic fluid reservoir oblique to the volcanic front in the southern part of NE Japan revealed by the magnetotelluric survey
Authors: Diba Dieno , Uyeshima Makoto , Ichiki Masahiro , Sakanaka Shin’ya , Tamura Makoto , Yuan Yiren , Gresse Marceau , Yamaya Yusuke , Usui Yoshiya 
Published: September 2023

AbstractMany active volcanoes and various types of seismic activities exist in the southern part of the Northeast Japan subduction zone. One of the geologically most interesting features in this area is the sequential explosive eruptions of a group of volcanoes. The group consists of Mt. Azuma and Mt. Adatara on the volcanic front line, Mt. Bandai west of the volcanic front, and Mt. Numazawa on the back-arc side. A previous petrological study on the eruption products regarded Mt. Numazawa as an anomalous back-arc volcano because its lavas are similar to those of volcanoes on the volcanic front. The reason behind this unique connection was unclear, and hence, this study was intended to understand the deep fluids distribution beneath the area. For this purpose, a 3-D regional electrical resistivity structure was estimated from a series of wide-band magnetotelluric surveys, with 45 observation points deployed from the fore-arc to the back-arc sides. The most important feature of the resistivity structure is a large conductive zone in the central part of the area, spanning from the upper mantle to the lower crust. Interestingly, the lateral elongation of the conductor is oblique to the volcanic front line and consistent with the spatial distribution of the group of volcanoes and the low-frequency earthquake clusters around them. Therefore, the conductor most likely represents a large, elongated magmatic fluid reservoir beneath the volcanoes. Hydrous partial melting might be the cause of the enhanced conductivity.
Graphical Abstract
Tyrosine-kinase inhibitor combined with iodine-125 seed brachytherapy for hepatocellular carcinoma refractory to transarterial chemoembolization: a propensity-matched study
Authors: Guo Yongjian , Wu Jingqiang , Liang Licong , Zhu Kangshun , Zhou Jingwen , Lin Liteng , Chen Ye , Cao Bihui , He Mingji , Lian Hui , Huang Wensou , Cai Mingyue 
Published: September 2023

Abstract
Purpose
To investigate the efficacy and safety of tyrosine-kinase inhibitor (TKI) combined with iodine-125 seed brachytherapy (TKI-I) versus TKI alone for patients with hepatocellular carcinoma (HCC) refractory to transarterial chemoembolization (TACE).

Methods
Data of patients with TACE-refractory HCC who received TKI (sorafenib or lenvatinib) or TKI-I from September 2018 to December 2020 were retrospectively analyzed. A propensity score matching (PSM) was performed to diminish potential bias. The primary endpoints were overall survival (OS) and time to progression (TTP). Tumor responses and treatment-related adverse events (TRAEs) were also compared between the two groups.

Results
A total of 132 patients were included in this study. Under PSM, 48 paired patients were selected for comparison. The median OS was 23.2 (95% CI 20.9–25.1) months in the TKI-I group versus 13.9 (95% CI 11.1–16.7) months in the TKI group (P < 0.001). The median TTP was 12.8 (95% CI 10.1–15.5) months in the TKI-I group versus 5.8 (95% CI 5.0-6.6) months in the TKI group (P < 0.001). Patients in the TKI-I group had higher objective response rate (68.8% vs. 33.3%, P = 0.001) and disease control rate (89.6% vs. 66.7%, P = 0.007) than those in the TKI group. The incidence and severity of TRAEs in the TKI-I group were comparable to those in the TKI group (any grade, 89.7% vs. 92.2%, P = 0.620; ≥grade 3, 33.8% vs. 32.8%, P = 0.902).

Conclusions
TKI-I was safe and significantly improved survival over TKI alone in HCC patients with TACE refractoriness.
Rhenium solubility and speciation in aqueous fluids at high temperature and pressure
Authors: Mysen Bjorn 
Published: September 2023

AbstractIn order to characterize rhenium transport via infiltration of fluids in the Earth's interior, the solubility and solution mechanisms of ReO2 in aqueous fluids were determined to 900 °C and about 1710 MPa by using an externally–heated hydrothermal diamond anvil cell. In order to shed light on how Re solubility and solution mechanisms in aqueous fluids can be affected by interaction of Re with other solutes, compositions ranged from the comparatively simple ReO2–H2O system to compositionally more complex Na2O–ReO2–SiO2–H2O fluids. Fluids in the ReO2–SiO2–H2O, SiO2–H2O, Na2O–SiO2–H2O, and Na2O–ReO2–H2O systems also were examined. The presence of Na2O enhances the ReO2 solubility so that in Na2O–ReO2–H2O fluids, for example, Re solubility is increased by a factor of 10–15 compared with the Re solubility in Na2O-free ReO2–H2O fluids. The SiO2 component in ReO2–SiO2–H2O causes reduction of ReO2 solubility compared with ReO2–H2O fluids. The ReO2 solubility in the Na-bearing Na2O–ReO2–SiO2–H2O fluids is greater than that in fluids in both the ReO2–H2O and ReO2–SiO2–H2O systems. Rhenium is dissolved in aqueous fluid as ReO4-complexes with Re in fourfold coordination with oxygen. Some, or all, of the oxygen in these complexes is replaced by OH-groups depending on whether Na2O also is present. It is proposed that during dehydration of hydrated subduction zone mineral assemblages in the upper mantle, the alkali/alkaline earth ratio of the source of the released aqueous fluid affects the extent to which Re (and other HFSE) can be transported into an overlying peridotite mantle wedge. The infiltration of such fluids will, in turn, affect the Re content (and Re/Os ratio) of magma formed by partial melting of this peridotite wedge.
Effect of Hypoxia Conditioning on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis
Authors: He Zhijian , Qiang Lijun , Liu Yusheng , Gao Wenfeng , Feng Tao , Li Yang , Yan Bing , Girard Olivier 
Published: September 2023

Abstract
Background
The effects of hypoxia conditioning, which involves recurrent exposure to hypoxia combined with exercise training, on improving body composition in the ageing population have not been extensively investigated.

Objective
This meta-analysis aimed to determine if hypoxia conditioning, compared to similar training near sea level, maximizes body composition benefits in middle-aged and older adults.

Methods
A literature search of PubMed, EMBASE, Web of Science, Scopus and CNKI (China National Knowledge Infrastructure) databases (up to 27th November 2022) was performed, including the reference lists of relevant papers. Three independent reviewers extracted study characteristics and health outcome measures. Search results were limited to original studies of the effects of hypoxia conditioning on body composition in middle-aged and older adults.

Results
Twelve studies with a total of 335 participants were included. Hypoxia conditioning induced greater reductions in body mass index (MD = -0.92, 95%CI: -1.28 to -0.55, I2 = 0%, p < 0.00001) and body fat (SMD = -0.38, 95%CI: -0.68 to -0.07, I2 = 49%, p = 0.01) in middle-aged and older adults compared with normoxic conditioning. Hypoxia conditioning improved lean mass with this effect not being larger than equivalent normoxic interventions in either middle-aged or older adults (SMD = 0.07, 95%CI -0.12 to 0.25, I2 = 0%, p = 0.48). Subgroup analysis showed that exercise in moderate hypoxia (FiO2 > 15%) had larger effects than more severe hypoxia (FiO2 ≤ 15%) for improving body mass index in middle-aged and older adults. Hypoxia exposure of at least 60 min per session resulted in larger benefits for both body mass index and body fat.

Conclusion
Hypoxia conditioning, compared to equivalent training in normoxia, induced greater body fat and body mass index improvements in middle-aged and older adults. Adding hypoxia exposure to exercise interventions is a viable therapeutic solution to effectively manage body composition in ageing population.
Patients’ experiences with participating in a team-based person-centred intervention for patients at risk of or diagnosed with COPD in general practice
Authors: Kolltveit Beate-Christin Hope , Graue Marit , Borge Christine Råheim , Frisk Bente 
Published: September 2023

Abstract
Background
Symptoms and complications of chronic obstructive pulmonary disease (COPD) can affect daily activities and quality of life, and patients with COPD require long-term follow-up by their general practitioner. Providing patients with or at risk of COPD practical skills and motivation to improve their self-management is important. On this background, an interdisciplinary follow-up program was designed based on the Guided Self-Determination counselling method to facilitate problem-solving and mutual decision-making between healthcare professionals and patients. The aim of the study was to explore patients and healthcare professionals` experiences with the Guided Self-Determination-program to investigate feasibility issues.

Methods
A qualitative design was used to get insights in the experiences of receiving the Guided Self-Determination counselling program. In total, 13 patients with COPD (mean age 71.7 ± 7.7 years) 4 were current smokers, and 7 at risk of COPD (mean age 54.1 ± 9.9 years) all current smokers, received the Guided Self-Determination program. The researchers performed individual semi-structured telephone interviews after the 12 months Guided Self-Determination program with two patients at risk of COPD, four patients with COPD, three nurses, and five general practitioners. The intervention consisted of structured consultations with the nurse and patient in collaboration with the general practitioner at baseline and after 3, 6, and 12 months. The Guided Self-Determination method comprised facilitation of a mutual reflection process between the patient and the nurse to enhance self-management skills. Each consultation lasted for 60 min. The interviews were analysed using thematic analyses.

Results
Two themes were identified: (1) A structured follow-up is challenging but motivating. (2) A counselling method that opens for conversation, but it requires resources.

Conclusions
The findings indicated that patients with or at risk of COPD experienced enhanced self-management skills after participating in a structured and systematic team-based follow-up in general practice with use of the Guided Self-Determination method. The regularity of the follow-up seemed to be important to succeed to help the patients making lifestyle changes to increase health benefits. However, the Guided Self-Determination method was experienced as time consuming among the general practitioners and nurses, and there are currently no available financial rates for this type of treatment in Norway which may be a barrier to further implementation.

Trial registration
The trial is registered in ClinicalTrials.gov (ID: NCT04076384).
Biocompatible Ti
3
Au–Ag/Cu thin film coatings with enhanced mechanical and antimicrobial functionality
Authors: Lukose Cecil Cherian , Anestopoulos Ioannis , Panagiotidis Iraklis-Stavros , Zoppi Guillaume , Black Anna M. , Dover Lynn G. , Bowen Leon , Serrano-Aroca Ángel , Liu Terence Xiaoteng , Mendola Lorenzo , Morrone Davide , Panayiotidis Mihalis I. , Birkett Martin 
Published: September 2023

Abstract

Background

Biofilm formation on medical device surfaces is a persistent problem that shelters bacteria and encourages infections and implant rejection. One promising approach to tackle this problem is to coat the medical device with an antimicrobial material. In this work, for the first time, we impart antimicrobial functionality to Ti
3
Au intermetallic alloy thin film coatings, while maintaining their superior mechanical hardness and biocompatibility.

Methods

A mosaic Ti sputtering target is developed to dope controlled amounts of antimicrobial elements of Ag and Cu into a Ti
3
Au coating matrix by precise control of individual target power levels. The resulting Ti
3
Au-Ag/Cu thin film coatings are then systematically characterised for their structural, chemical, morphological, mechanical, corrosion, biocompatibility-cytotoxicity and antimicrobial properties.

Results

X-ray diffraction patterns reveal the formation of a super hard β-Ti
3
Au phase, but the thin films undergo a transition in crystal orientation from (200) to (211) with increasing Ag concentration, whereas introduction of Cu brings no observable changes in crystal orientation. Scanning and transmission electron microscopy analysis show the polyhedral shape of the Ti
3
Au crystal but agglomeration of Ag particles between crystal grains begins at 1.2 at% Ag and develops into large granules with increasing Ag concentration up to 4.1 at%. The smallest doping concentration of 0.2 at% Ag raises the hardness of the thin film to 14.7 GPa, a 360% improvement compared to the ∼4 GPa hardness of the standard Ti
6
Al
4
V base alloy. On the other hand, addition of Cu brings a 315—330% improvement in mechanical hardness of films throughout the entire concentration range of 0.5—7.1 at%. The thin films also show good electrochemical corrosion resistance and a > tenfold reduction in wear rate compared to Ti
6
Al
4
V alloy. All thin film samples exhibit very safe cytotoxic profiles towards L929 mouse fibroblast cells when analysed with Alamar blue assay, with ion leaching concentrations lower than 0.2 ppm for Ag and 0.08 ppm for Cu and conductivity tests reveal the positive effect of increased conductivity on myogenic differentiation. Antimicrobial tests show a drastic reduction in microbial survival over a short test period of < 20 min for Ti
3
Au films doped with Ag or Cu concentrations as low as 0.2—0.5 at%.

Conclusion

Therefore, according to these results, this work presents a new antimicrobial Ti
3
Au-Ag/Cu coating material with excellent mechanical performance with the potential to develop wear resistant medical implant devices with resistance to biofilm formation and bacterial infection.

Graphical Abstract
The effects of low-fat dairy products fortified with 1500 IU vitamin D3 on serum liver function biomarkers in adults with abdominal obesity: a randomized controlled trial
Authors: Sharifan Payam , Darroudi Susan , Rafiee Mahdi , Roustai Geraylow Kiarash , Hemmati Romina , Rashidmayvan Mohammad , Safarian Mohamad , Eslami Saeid , Vatanparast Hassan , Zare-Feizabadi Reza , Mohammadi-Bjgiran Maryam , Ghazizadeh Hamideh , Khorasanchi Zahra , Bagherniya Mohammad , Ferns Gordon , Rezaie Mitra , Ghayour-Mobarhan Majid 
Published: September 2023

Abstract
Introduction
Vitamin D deficiency has been reported to affect liver function biomarkers. This study was aimed to investigate the effect of consuming vitamin D fortified low-fat dairy products on liver function tests in adults with abdominal obesity.

Methods
This total blinded randomized controlled trial was undertaken on otherwise healthy abdominally obese adults living in Mashhad, Iran. Milk and yogurt were fortified with 1500 IU vitamin D3 nano-capsules. Participants were randomized to receive fortified milk (n = 73), plain milk (n = 73), fortified yogurt (n = 69), and plain yogurt (n = 74) for 10 weeks. Blood samples were taken at baseline and at the end of the study to assess serum levels of vitamin D, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase (ALP), and Gamma glutamyl transferase.

Results
A total of 289 participants completed the study (54% female). The groups were homogenous in terms of age, sex, weight, energy intake, and physical activity level (p-value > 0.05). After the trial, vitamin D serum levels were significantly increased in both groups receiving fortified products (both p < 0.001). There was a significant time*group effect only in serum ALP (p < 0.001).

Conclusion
Consumption of dairy products fortified by 1500 IU vitamin D3 might have detrimental effects on serum levels of some liver enzymes in individuals with abdominal obesity. Further studies needed to determine these effects and underlying mechanisms.
Trial registration: IRCT20101130005280N27.