bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistemas de costes de calidad para establecimientos de alojamiento turístico
Authors: Mayorga Ases Maria Jose , Velastegui Hernández Rommel Santiago , Mayorga Ases Leticia Abigail , Carranza Calero Diego Mauricio 
Published: August 2023

Introducción. Los sistemas de coste de la calidad (COQ), son metodologías que permiten a los establecimientos de alojamiento turístico evaluar sus recursos se utilizan para relacionadas con la calidad. La implantación de sistemas de costes de calidad es crucial para controlar eficazmente los costes y garantizar la prestación de experiencias de alta calidad a los clientes. Al identificar los distintos tipos de costes de calidad, como los costes de prevención y los costes de evaluación para mejorar su reputación, generar confianza entre los clientes y aumentar su fidelidad. La superación de estos retos requiere una comprensión global de los componentes críticos de la gestión de la calidad en el sector de la hostelería y la integración de los sistemas de costes de calidad en las estrategias generales de gestión. Objetivo. Analizar la importancia del análisis de los costos de la calidad para generar confianza a los clientes. Metodología. Por medio de diez pasos se utiliza una metodología de revisión bibliográfica que consiste en recopilar, analizar y sintetizar la información relevante de diversas fuentes, como libros, artículos académicos y otros documentos, para presentar una visión general del estado del conocimiento sobre los sistemas de costes de calidad para establecimientos de alojamiento turístico. Resultados. Se obtienen ocho resultados principales entre los cuales tenemos: 1. tipos de costes de calidad en los establecimientos de alojamiento turístico. 2. costes de prevención en los establecimientos de alojamiento turístico. 3.costes de evaluación en los establecimientos de alojamiento turístico. 4.costes por fallos internos en establecimientos de alojamiento turístico. 5.costes externos de fracaso en los establecimientos de alojamiento turístico. 6.ventajas de implantar un sistema de costes de calidad en los establecimientos de alojamiento turístico 7. retos de la implantación de un sistema de costes de calidad en los establecimientos de alojamiento turístico. 8.casos prácticos de implantación con éxito de sistemas de costes de calidad en establecimientos de alojamiento turístico. Conclusión. Los sistemas de costes de calidad desempeñan un papel crucial para garantizar el éxito y la competitividad de los establecimientos de alojamiento turístico. La implantación de sistemas de costes de calidad en los establecimientos de alojamiento turístico es crucial para garantizar la mejora continua y el control de la calidad de los servicios prestados, los establecimientos pueden controlar eficazmente los costes y mejorar la experiencia general de los huéspedes. Por medio de la colaboración con las partes interesadas y la adopción de las mejores prácticas, los establecimientos de alojamiento turístico pueden mejorar sus sistemas de costes de calidad y, en última instancia, ofrecer una mejor experiencia a sus huéspedes.
A Retrospective Study on Previously Untreated Non-metastatic Breast Cancer Patients at a Tertiary Care Hospital
Authors: Elahi Md Quadrat E , Islam Md Azizul , Sarwar SM Rahid , Sarkar Fatima 
Published: August 2023

Introduction: The combination of adoxorubicin and cyclophosphamide (AC) followed by a taxane (Docetaxel or Paclitaxel) and epirubicin and cyclophosphamide (EC) followed by a taxane (Docetaxel or Paclitaxel) is a standard regimen for breast cancer patients. In this study, we compared the three-year overall survival (OS) and progression free survival (PFS) of a patient with previously untreated non-metastatic breast cancer patients.
Objectives: To find out the overall survival and progression free survival among previously untreated non-metastatic breast cancer patients after standard chemotherapy.
Methods: Fifty-six patients received four cycles of doxorubicin at a dose of 60mg/m2 and cyclophosphamide at a dose of 600 mg/m2 followed by four cycles of paclitaxel at a dose of 175mg/m2. Thirteen patients received AC followed by four cycles of docetaxel at a dose of 75mg/m2. Twenty-one patients received four cycles of epirubicin (75mg/m2) and cyclophosphamide (600mg/m2), followed by four cycles of paclitaxel (175mg/m2). Twelve patients were given EC followed by four cycles of docetaxel (75mg/m2).
Results: The four groups of patients had similar characteristics. Overall survivalafter three years was 92% in AC followed by paclitaxel, 98% in AC followed by docetaxel, 95% and 97% in EC followed by paclitaxel and docetaxel respectively. One year of PFS in AC followed by paclitaxel and docetaxel was 98% and 100% respectively whereas in EC followed by paclitaxel and docetaxel were 98% and 98% respectively. The four arms had 96%, 98%, 97% and 96% PFS after two years respectively. This research also revealed that four chemotherapy regimens had three-year survival rates of 93%, 98%, 93% and 96% respectively.
Conclusion: AC or EC followed by taxane regimens well suitable regimens for the population of patients with previously untreated non-metastatic breast cancer patients. The findings show the need for continued observation as well as taking into account the treatment of other patients throughout different periods.
JAFMC Bangladesh. Vol 18, No 2 (December) 2022: 11-14
Treatment of Retinopathy of Prematurity by Intravitreal Injection of Bevacizumab
Authors: Hossain Mohammad Ismail , Khan Kamrul Hasan , Sultana Jesmin , Hasan Zulfikar , Hossain Billal , Kadir Syeed Mehbub Ul 
Published: August 2023

Introduction: Retinopathy of prematurity is a vasoproliferative disease of the developing retina that is a significant cause of paediatric morbidity and blindness worldwide. Although management by early treatment ROP (ETROP) criteria has led the way to improving the outcomes of treatment-requiring posterior (zone 1) ROP, the failure rate continues to be significant for aggressive disease. Managing a premature infant with ROP is a significant challenge to ophthalmologists and associated physicians. However, increasingly younger and lower birth-weight infants can survive with advances in neonatal care.
Objectives: To assess the effectiveness of intravitreal injection of Bevacizumab on regression of retinal neovascularization in stage III, Zone 1, 2 retinopathy of prematurity and aggressive posterior retinopathy of prematurity.
Methods: Intravitreal Injection of Bevacizumab (0.625mg/0.025mL) was performed on 34 eyes of 17 newborns with stage III, Zone 1, 2 retinopathy of prematurity and aggressive posterior retinopathy of prematurity. The changes in retinal neovascularization were assessed by frequent fundoscopy.
Results: Retinopathy of prematurity regressed in all the eyes treated. The retinal vascularization proceeded beyond the demarcation line. Four eyes of 2 patients needed repeat injections. One eye needed an additional laser. There was no injection-related complication observed.
Conclusion: Intravitreal injection of Bevacizumab can be considered an effective modality in treating Retinopathy of Prematurity. It is recommended to perform more studies to assess its long-term effect on the body's vascular system.
JAFMC Bangladesh. Vol 18, No 2 (December) 2022: 24-27
Study of Risk Factors and Foeto-maternal Outcome of Gestational Diabetes Mellitus
Authors: Chisty Shahnur , Alam Rifat Binte 
Published: August 2023

Introduction: Gestational diabetes mellitus (GDM) is a common pregnancy complication with complex disease mechanism. Several risk factors may contribute to its onset. Based on recent evidence up-to 15% of all pregnancies may be affected by GDM. Untreated GDM is a severe threat to maternal and neonatal health
Objectives: To determine the risk factors and foeto- maternal outcome of GDM.
Methods: This prospective observational study was conducted on patients who were admitted in Obstetrics & Gynaecology department of CMH, Bogura from June 2020 to May 2021 with the diagnosis of GDM. Data were collected from the patients as well as from the antenatal records in a preformed questionnaire and risk factors and outcomes measured.
Results: A total of 679 patients were admitted during the period of 1 year from June 2020 to May 2021. Among them 50 patients were admitted with GDM. The prevalence of GDM was 7.36%. GDM risks were higher in women aged between 25-29 years and in those with maternal overweight and obesity (58%). Newborns of GDM mother had an increased risk of hypoglycemia (10%), macrosomia (20%), respiratory distress syndrome (8 %) and 42% required NICU admission. Most of the patients (92%) needed cesarean section.
Conclusion: Pre-pregnancy BMI and family history of diabetes in first degree relatives and high parity were the predominant risk factor of GDM in this study. GDM patients are of increase risk of delivery by cesarean section, preterm birth, Newborns of GDM mother are at risk of RDS (Respiratory distress syndrome), macrosomia and neonatal hypoglycemia.
JAFMC Bangladesh. Vol 18, No 2 (December) 2022: 46-50
Effect of quercetin on steroidogenesis and folliculogenesis in ovary of mice with experimentally-induced polycystic ovarian syndrome
Authors: Shah Mohd Zahoor ul haq , Shrivastva Vinoy kumar , Mir Manzoor Ahmad , Sheikh Wajid Mohammad , Ganie Mohd Ashraf , Rather Gulzar Ahmed , Shafi Majid , Bashir Showkeen Muzamil , Ansari Mohammad Azam , Al-Jafary Meneerah A. , Al-Qahtani Mohammad H. , Homeida Abdalelgadir Musa , Al-Suhaimi Ebtesam A. 
Published: August 2023

IntroductionPolycystic Ovary syndrome (PCOS) affects the health of many women around the world. Apart from fundamental metabolic problems connected to PCOS, focus of our study is on the role of quercetin on genes relevant to steroidogenesis and folliculogenesis.MethodsEighteen mature parkes strain mice (4-5 weeks old) weighing 18–21 g were randomly divided into three groups of six each as follows: Group I serves as the control and was given water and a regular chow diet ad lib for 66 days; group II was given oral gavage administration of letrozole (LETZ) (6 mg/kg bw) for 21 days to induce PCOS and was left untreated for 45 days; For three weeks, Group III received oral gavage dose of LETZ (6 mg/kg), after which it received Quercetin (QUER) (125 mg/kg bw orally daily) for 45 days.ResultsIn our study we observed that mice with PCOS had irregular estrous cycle with increased LH/FSH ratio, decreased estrogen level and decline in expression of Kitl, Bmp1, Cyp11a1, Cyp19a1, Ar, lhr, Fshr and Esr1 in ovary. Moreover, we observed increase in the expression of CYP17a1, as well as increase in cholesterol, triglycerides, testosterone, vascular endothelial growth factor VEGF and insulin levels. All these changes were reversed after the administration of quercetin in PCOS mice.DiscussionQuercetin treatment reversed the molecular, functional and morphological abnormalities brought on due to letrozole in pathological and physiological setting, particularly the issues of reproduction connected to PCOS. Quercetin doesn’t act locally only but it acts systematically as it works on Pituitary (LH/FSH)- Ovary (gonad hormones) axis. the Side effects of Quercetin have to be targeted in future researches. Quercetin may act as a promising candidate for medical management of human PCOS.
Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review
Authors: Pledger Sophia L. , Ahmadizar Fariba 
Published: August 2023

BackgroundObesity represents a major and preventable global health challenge as a complex disease and a modifiable risk factor for developing other non-communicable diseases. In recent years, obesity prevalence has risen more rapidly in low- and middle-income countries (LMICs) compared to high-income countries (HICs). Obesity traits are shown to be modulated by an interplay of genetic and environmental factors such as unhealthy diet and physical inactivity in studies from HICs focused on populations of European descent; however, genetic heterogeneity and environmental differences prevent the generalisation of study results to LMICs. Primary research investigating gene-environment interactions (GxE) on obesity in LMICs is limited but expanding. Synthesis of current research would provide an overview of the interactions between genetic variants and environmental factors that underlie the obesity epidemic and identify knowledge gaps for future studies.MethodsThree databases were searched systematically using a combination of keywords such as “genes”, “obesity”, “LMIC”, “diet”, and “physical activity” to find all relevant observational studies published before November 2022.ResultsEighteen of the 1,373 articles met the inclusion criteria, of which one was a genome-wide association study (GWAS), thirteen used a candidate gene approach, and five were assigned as genetic risk score studies. Statistically significant findings were reported for 12 individual SNPs; however, most studies were small-scale and without replication.ConclusionAlthough the results suggest significant GxE interactions on obesity in LMICs, updated robust statistical techniques with more precise and standardised exposure and outcome measurements are necessary for translatable results. Future research should focus on improved quality replication efforts, emphasising large-scale and long-term longitudinal study designs using multi-ethnic GWAS.
The clinical value of progestin-primed ovarian stimulation protocol for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis
Authors: Lin Guangyao , Zhong Xiufang , Li Shengnan , Liu Xiyu , Xu Lianwei 
Published: August 2023

BackgroundTo determine whether progestin-primed ovarian stimulation (PPOS) is more effective for women with diminished ovarian reserve (DOR) than clomiphene citrate (CC)/letrozole (LE) plus gonadotropin in IVF or ICSI treatment.MethodsNine databases were searched until May 24, 2023, to identify relevant studies. Forest plots were used to present the results of this meta-analysis. Begg’s and Egger’s tests were applied to estimate publication bias. Subgroup and sensitivity analysis were performed to check the potential sources of heterogeneity and verify the robustness of the pooled results, respectively.ResultsA total of 14 studies with 4182 participants were included for meta-analysis. There was evidence of a statistically notable increase in clinical pregnancy rate (OR = 1.39, 95%CI [1.01, 1.91], p = 0.05), optimal embryos rate (OR = 1.50, 95%CI [1.20, 1.88], p = 0.0004), and cumulative pregnancy rate (OR = 1.73, 95%CI [1.14, 2.60], p = 0.009), the duration and the amount of gonadotropin required (MD = 1.56, 95%CI [0.47, 2.66], p = 0.005; SMD = 1.51, 95%CI [0.90, 2.12], p &lt; 0.00001), along with decrease cycle cancellation rate (OR = 0.78, 95%CI [0.64, 0.95], p = 0.02), luteinizing hormone (LH) level on the day of hCG (SMD = -0.81, 95%CI [-1.10, -0.53], p &lt; 0.00001), and premature LH surge rate (OR = 0.10, 95%CI [0.07, 0.15], p &lt; 0.00001) when PPOS was used. No evidence for publication bias within results was revealed.ConclusionsBased on evidence-based results, PPOS protocol seems to improve IVF/ICSI outcomes for women with DOR. More research with larger sample sizes and rigorous designs are required to further explore the value of PPOS among women diagnosed with DOR.Systematic review registrationwww.crd.york.ac.uk, identifier CRD42023430202.
Effect of insulin resistance on gonadotropin and bone mineral density in nondiabetic postmenopausal women
Authors: Ye Shujin , Shi Lan , Zhang Zhifen 
Published: August 2023

ObjectiveThe effects of insulin resistance (IR) on bone mineral density (BMD) are unclear. This investigation aimed to assess the impact of IR and hyperinsulinemia on bone health. Determine whether IR mediates the link between follicle-stimulating hormone (FSH) and bone mass in nondiabetic postmenopausal women.DesignRetrospective cross-sectional study.SettingHealth checkup center of Hangzhou Women’s Hospital.MethodsThis study comprised 437 nondiabetic postmenopausal women. BMD was evaluated using dual-energy X-rays. Fasting sera were analyzed for insulin and glucose levels, and indicators related to IR were determined. By pathway analysis, we examined the indirect effects of FSH on BMD via the mediators Homeostatic Model Assessment for insulin resistance (HOMA-IR) and fasting insulin (FINS) after correction for confounding factors.ResultAfter adjusting for age and body mass index (BMI) in linear regression, HOMA-IR and FINS were linked with FSH (P&lt;0.05). IR was stronger among women in the normal BMD group than those in the osteoporosis or osteopenia group. In unadjusted models, BMD was greater in those with higher HOMA-IR and FINS (β=0.027, P=0.006 and β=0.033, P=0.003, respectively). After correcting for BMI and other possible variables, these associations remained. In addition, path models for FSH demonstrated a negative association with BMD by HOMA-IR (95% confidence interval [CI]: -0.0174 to -0.0014) and FINS (95% CI: -0.0188 to -0.002).ConclusionGreater IR was associated with increased BMD in nondiabetic postmenopausal women, regardless of BMI and other variables. HOMA-IR or FINS could play a novel mediating role in FSH-induced BMD suppression.
Invertebrate communities of Bay of Fundy salt marsh pools: comparison of a natural and recovering marsh
Authors: Noel Paula E. , Sharma Bidhya , Chmura Gail L. 
Published: August 2023

Disturbed salt marshes may recover with little additional management once tidal inundation is restored. We assessed the success of such recovery by comparing the invertebrate biota of Bay of Fundy salt marsh pools in a reference site at Dipper Harbour to that of Saints Rest marsh that had been drained for over a century and to which tidal flooding had been returned ~50 years prior to our study. The sediments and vegetation of salt marsh pools were sampled seasonally throughout one year. Average biomass of pool invertebrates ranged from 1.8 to 4.0 g dry wt m−2, depending on the amount of vegetation cover in the pools. The most abundant organisms of the pools were the gastropod Ecrobia truncata (=Hydrobia tottentei), Tubificidae (=Naididae) oligochaetes, and Chironomidae (=Chironomini). We compared overall abundance and biomass of the invertebrates in the pool communities, assessing the month of sampling, pool elevation, and source marsh as explanatory variables. Our analyses revealed that marsh origin of pools seldom explained a significant amount of variance, and when it did, the proportion of variance explained was usually lower than elevation of pools and month of sampling. Diversity of invertebrates found in all pools was higher at the recovering site with species richness &gt;40% higher than in the reference site. We conclude that after an estimated 50 years since dyke failure and return of tidal flooding to Saints Rest marsh, that the ecosystem function represented by pools and their fauna has recovered.
Identification of SNPs in MITF associated with beak color of duck
Authors: Pan Rui , Hua Tian , Guo Qixin , Bai Hao , Jiang Yong , Wang Zhixiu , Bi Yulin , Chen Guohong , Wu Xinsheng , Chang Guobin 
Published: August 2023

Introduction: Beak color—a pigment-related trait—is an important feature of duck breeds. Recently, little research has addressed genetic mechanism of the beak colors in poultry, whereas the process and the regulation factors of melanin deposition have been well described.Methods: To investigate the genetic mechanism of beak colors, we conducted an integrated analysis of genomic selection signatures to identify a candidate site associated with beak color. For this, we used black-billed (Yiyang I meat duck synthetic line H1, H2, H3&amp;HF) and yellow-billed ducks (Cherry Valley ducks and white feather Putian black duck). Quantitative real-time PCR and genotyping approaches were used to verify the function of the candidate site.Results: We identified 3,895 windows containing 509 genes. After GO and KEGG enrichment analysis, nine genes were selected. Ultimately, MITF was selected by comparing the genomic differentiation (FST). After loci information selection, 41 extreme significantly different loci were selected, which are all located in intron regions of MITF and are in almost complete linkage disequilibrium. Subsequently, the site ASM874695v1:10:g.17814522T &gt; A in MITF was selected as the marker site. Furthermore, we found that MITF expression is significantly higher in black-beaked ducks than in yellow-beaked ducks of the F2 generation (p &lt; 0.01). After genotyping, most yellow-billed individuals are found with homozygous variant; at the same time, there are no birds with homozygous variant in black-billed populations, while the birds with homozygous and heterozygous variant share the same proportion.Conclusion:MITF plays a very critical role in the melanogenesis and melanin deposition of duck beaks, which can effectively affect the beak color. The MITF site, ASM874695v1:10:g.17814522T &gt; A could be selected as a marker site for the duck beak color phenotype.
Case report: PIK3CA somatic mutation leading to Klippel Trenaunay Syndrome and multiple tumors
Authors: Serio Viola Bianca , Palmieri Maria , Innamorato Simona , Loberti Lorenzo , Fallerini Chiara , Ariani Francesca , Antolini Enrica , Covarelli Jasmine , Vaghi Massimo , Frullanti Elisa , Renieri Alessandra , Pinto Anna Maria 
Published: August 2023

We report a case of Klippel Trenaunay Syndrome that was monitored both clinically and molecularly over a period of 9 years. A somatic mosaic mutation of PIK3CA (p(E545G)) was identified using both cfDNA NGS liquid biopsy and tissue biopsy. At the age of 56, due to intervening clonal mutations in PIK3CA background, she developed a squamous cell carcinoma in the right affected leg which was treated surgically. Nine years later, lung bilateral adenocarcinoma arose on PIK3CA mutated tissues supported by different clonal mutations. One year later, the patient died from metastases led by a new FGFR3 clone unresponsive to standard-of-care, immunotherapy-based. Our results highlight the presence of a molecular hallmark underlying neoplastic transformation that occurs upon an angiodysplastic process and support the view that PIK3CA mutated tissues must be treated as precancerous lesions. Importantly, they remark the effectiveness of combining cfDNA NGS liquid and tissue biopsies to monitor disease evolution as well as to identify aggressive clones targetable by tailored therapy, which is more efficient than conventional protocols.