bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of poly(acrylic acid)/linseed mucilage/chitosan hydrogel for ketorolac release
Authors: Rodríguez‐Loredo Nashiely A. , Ovando‐Medina Víctor M. , Pérez Elías , Corona‐Rivera Miguel A. , Cervantes‐González Elsa , Antonio‐Carmona Iveth D. , Ramos‐Torres Claudia J. 
Published: May 2023

AbstractStudies of smart and biocompatible hydrogels have resulted in the development of efficient drug‐delivery systems controlled by external stimuli. Taking inadequate doses of ketorolac could cause health complications in humans. Therefore, it is necessary the development of a polymeric matrix for controlled drug delivery to extend the release of Ketorolac. In this work, acrylic acid was polymerized using ammonium persulfate as initiator and N,N′‐methylenebisacrylamide as a cross‐linking agent, and in the presence of chitosan (Chit) and linseed mucilage (LS) biopolymers to obtain a composite of PAAc/LS/Chit hydrogel which was used for adsorption and release of ketorolac. Hydrogel was characterized by cryo‐scanning electron microscopy (Cryo‐SEM), Fourier transform infrared spectroscopy, and thermogravimetric analysis. The effects of pH on water hydrogel swelling percentage (S), water absorption percentage (W), and ketorolac‐releasing kinetics were studied. SEM analysis showed hydrogel pore size pH‐depending, with micropore diameters ranging between 5 and 10 nm at acidic pH, while for the hydrogel swollen at pH = 9, bigger pores are observed in the range of 30 to 50 nm. It was observed that S and W increased with the pH of the medium with an S of 608% at a pH of 9 following a Fickian behavior of water diffusion into the hydrogel pore and swelling kinetics represented by a second‐order model. Ketorolac kinetic release was well described through the Korsmeyer‐Peppas mathematical model, with the release rate increasing with the pH, extending the total release time of drug to 20 h.
Feline urethral obstruction secondary to a ballistic foreign object
Authors: Bracchi Lauren , Odunayo Adesola , Ham Kathleen 
Published: May 2023

AbstractAn 8‐year‐old, male neutered, domestic shorthair cat was presented for stranguria, abnormal behaviour and azotaemia. A diagnosis of urethral obstruction was made based on a firm and painful urinary bladder that could not be expressed. Diagnostic workup, inclusive of bloodwork, urinalysis, urine culture and abdominal radiographs, revealed an intraluminal ballistic foreign object. A urinary tract infection was also diagnosed, suspected to be secondary to the ballistic foreign object. A cystotomy was performed and a metallic pellet was removed from the bladder lumen, with no overt signs of a penetrating injury appreciated on evaluation of the body wall and urinary bladder. Clinical signs resolved after surgical intervention, with normal urination appreciated at home after discharge. Urinary obstruction and infection secondary to an intraluminal foreign body is an unusual aetiology for a common feline presenting complaint, and diagnostic imaging should be strongly considered for any patient with a urinary obstruction.
Links between pet ownership and exercise on the mental health of veterinary professionals
Authors: Smith Elliot T. , Barcelos Ana Maria , Mills Daniel S. 
Published: May 2023

AbstractBackgroundConnections between the effects of pet ownership and exercise on mental health have previously been demonstrated in different populations. However, little is known about the potential effects of pet ownership and exercise on the mental health of veterinary professionals. Since these individuals have a high prevalence of poor mental health and suicide, while they deal with pets professionally, we investigated the impact of pet ownership, exercise and different types of pet ownership on this demographic group.MethodVeterinary professionals over 18 years old answered an online questionnaire about pet ownership, exercise, mental health (including anxiety, depression and suicidal ideation) and mental health correlates. Regression models were used to identify variables significantly related to mental health outcomes.ResultsOf 1087 respondents, pet owners were more depressed than non‐owners, while anxiety or suicidal ideation was not associated with pet ownership. Dog and horse owners were psychologically healthier (less anxiety, less suicidal ideation) than non‐owners of these species. Veterinary professionals who ran regularly had lower anxiety and depression. Those who walked regularly and spent less time sitting experienced fewer depression symptoms.ConclusionsRunning, walking and avoiding prolonged sitting might protect the mental health of veterinary professionals. The type of pet owned may be an important factor in the relationship between pet ownership and mental health; however, generally, pet ownership was associated with worse mental health outcomes in this demographic group. Future studies should determine the causal nature of these relationships.
Asymptotic expansion for solution of Maxwell equation in domain with highly oscillating boundary
Authors: Boujemaa Saoussen , Khelifi Abdessatar 
Published: May 2023

AbstractIn this paper, we derive high‐order terms in the asymptotic expansions of the boundary perturbations for the electric field by taking into account of highly oscillating perturbations of an inhomogeneity with regular boundary. We show then that the asymptotic expansions depend on some parameter γ, that describes the depth of irregularity. Our study is rigorous and is founded on Field expansion method.
Introduction: Civil Society Responses to Changing Civic Spaces
Authors: Biekart Kees , Kontinen Tiina , Millstein Marianne 
Published: May 2023

AbstractThis introductory chapter contextualizes how the volume resonates to current global trends and research debates concerning democracy, civil society, and civic space. The chapter shows how the debates on the decline of democracy, civil society actors, and changing civil spaces underpin the book’s agenda of exploring civil society responses to civic space. The chapter argues in favour of contextual and relational analyses of how civil society actors and civic space are negotiated, in the context of historically formed governance systems. It also provides an overview of the chapters of the book underlying their original contributions to ongoing debates.
Conclusions: Spaces of Hope and Despair?
Authors: Biekart Kees , Kontinen Tiina , Millstein Marianne 
Published: May 2023

AbstractThis concluding chapter summarizes the key findings of the individual chapters. It recaps the diverse conceptualizations of civic space used, as well as the restrictions and civil society responses identified. The chapter concludes with reflections on other perspectives not elaborated in this particular volume and on potential agendas for future research.
Philanthropy During COVID-19 Emergency: Towards a Postcolonial Perspective?
Authors: Mendonça Patricia Maria E. , Aoqui Cássio , Cardoso Leticia 
Published: May 2023

AbstractCivic actors started facing an increasingly challenging context with demobilization in recent years in Brazil. In 2019, a conservative government came to power, and the beginning of the pandemic led to deepening inequalities. That was when philanthropy emerged at its strongest: over US $1 billion in private donations were mapped in only three months. This paper presents data on donations during the pandemic and contrasts selected cases with different perspectives of philanthropy. It seeks to answer whether these donations may have had an outlier content for both donors and communities. It was observed that some initiatives started to break with hegemonic models of philanthropy, however, we argue that there is still a high level of resource-dependency from elites and a coloniality of power mindset, which leaves us to the question: “To what extent is a decolonial turn in philanthropy really achievable if its origin is based on colonial thoughts?”.
Beacons of Hope in a Challenging World: Conclusions and Directions for Future Research and Practice
Authors: Guse Tharina , Slezackova Alena , Krafft Andreas M. 
Published: May 2023

AbstractThis chapter summarizes the main tenets of our integrated hope model, followed by salient findings regarding hope in various countries and cultures, reported in this volume. We then identify challenges and future directions for research on hope across cultures and contexts.
Worldviews and Basic Beliefs of Hope
Authors: Krafft Andreas M. , Guse Tharina , Kasprzak Elżbieta , Redlich-Amirav Dorit , Stecz Patryk 
Published: May 2023

AbstractTo further elaborate on the concept of hope outlined in Chap.2, the purpose of this contribution is to investigate the role of basic beliefs and worldviews in sustaining the general perception of hope in different cultures. We begin by introducing the theoretical concepts about the nature of basic beliefs and worldviews, especially with regard to a future-oriented thinking. Employing the Perceived Hope Scale, the Dispositional Hope Scale, the Assumptive Worldviews, and several variables of subjective and psychological well-being, we investigate the levels and predictors of hope in six distinct samples of the Hope Barometer 2017 (N = 6548). Our findings support the notion of hope as a multidimensional phenomenon with certain universal features across cultures while recognizing that people in different cultures experience hope based on specific worldviews, independently from the nation’s economic wealth.
The Extended Frobenius Problem for Fibonacci Sequences Incremented by a Fibonacci Number
Authors: Robles-Pérez Aureliano M. , Rosales José Carlos 
Published: May 2023

AbstractWe study the extended Frobenius problem for sequences of the form $$\{f_a+f_n\}_{n\in \mathbb {N}}$$

{

f
a

+

f
n

}

n
∈
N

, where $$\{f_n\}_{n\in \mathbb {N}}$$

{

f
n

}

n
∈
N

is the Fibonacci sequence and $$f_a$$

f
a

is a Fibonacci number. As a consequence of this study, we show that the family of numerical semigroups associated with these sequences satisfies Wilf’s conjecture.
Epsilon Regularity for the Navier–Stokes Equations via Weak-Strong Uniqueness
Authors: Albritton Dallas , Barker Tobias , Prange Christophe 
Published: May 2023

AbstractWe give a new concise proof of a certain one-scale epsilon regularity criterion using weak-strong uniqueness for solutions of the Navier–Stokes equations with non-zero boundary conditions. It is inspired by an analogous approach for the stationary system due to Struwe.
An inviscid free boundary fluid-wave model
Authors: Kukavica Igor , Tuffaha Amjad 
Published: May 2023

AbstractWe consider the local existence and uniqueness of solutions for a system consisting of an inviscid fluid with a free boundary, modeled by the Euler equations, in a domain enclosed by an elastic boundary, which evolves according to the wave equation. We derive a priori estimates for the local existence of solutions and also conclude the uniqueness. Both, existence and uniqueness are obtained under the assumption that the Euler data belongs to$$H^{r}$$Hr, where$$r>2.5$$r>2.5, which is known to be the borderline exponent for the Euler equations. Unlike the setting of the Euler equations with vacuum, the membrane is shown to stabilize the system in the sense that the Rayleigh–Taylor condition does not need to be assumed.
Influence of hyperthermic intraperitoneal chemotherapy on renal blood perfusion
Authors: Liesenfeld Lukas F. , Brandl Andreas 
Published: May 2023

Abstract
Purpose
Hyperthermic intraperitoneal chemotherapy (HIPEC) is accompanied with an increased risk of acute kidney injury (AKI). Whether AKI is induced by chemotoxicity or hyperthermia-related changes in renal perfusion remains controversial. The influence of HIPEC on renal perfusion has not been evaluated in patients yet.

Methods
Renal blood perfusion was assessed in ten patients treated with HIPEC by intraoperative renal Doppler pulse-wave ultrasound. Ultrasound (US) examinations were performed pre-, intra-, and postoperative with analyses of time-velocity curves. Patient demographics, surgical details, and data regarding renal function were recorded perioperatively. For evaluation of renal Doppler US to predict AKI, patients were divided in two groups with (AKI +) and without (AKI −) kidney injury.

Results
Throughout HIPEC perfusion, neither significant nor consistent changes in renal perfusion could be observed. Postoperative AKI occurred in 6 of 10 participating patients. Intraoperative renal resistive index (RRI) values > 0.8 were observed in one patient developing stage 3 AKI according KDIGO criteria. At 30 min in perfusion, RRI values were significantly higher in AKI + patients.

Conclusion
AKI is a common and frequent complication after HIPEC, but underlying pathophysiology remains elusive. High intraoperative RRI values may indicate an increased risk of postoperative AKI. Present data challenges the relevance of hyperthermia-derived hypothesis of renal hypoperfusion with prerenal injury during HIPEC. More attention should be drawn towards chemotoxic-induced hypothesis of HIPEC-induced AKI and caution applying regimens containing nephrotoxic agents in patients. Further confirmatory and complementary studies on renal perfusion as well as pharmacokinetic HIPEC studies are required.
Diagnostic applications and therapeutic option of Cascade CRISPR/Cas in the modulation of miRNA in diverse cancers: promises and obstacles
Authors: Alinejad Tahereh , Modarressi Shabnam , Sadri Zahra , Hao Zuo , Chen Cheng Shui 
Published: May 2023

AbstractThe Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas technology is a molecular tool specific to sequences for engineering genomes. Among diverse clusters of Cas proteins, the class 2/type II CRISPR/Cas9 system, despite several challenges, such as off-target effects, editing efficiency, and efficient delivery, has shown great promise for driver gene mutation discovery, high-throughput gene screening, epigenetic modulation, nucleic acid detection, disease modeling, and more importantly for therapeutic purposes. CRISPR-based clinical and experimental methods have applications across a wide range of areas, especially for cancer research and, possibly, anticancer therapy. On the other hand, given the influential role of microRNAs (miRNAs) in the regulations of cellular division, carcinogenicity, tumorigenesis, migration/invasion, and angiogenesis in diverse normal and pathogenic cellular processes, in different stages of cancer, miRNAs are either oncogenes or tumor suppressors, according to what type of cancer they are involved in. Hence, these noncoding RNA molecules are conceivable biomarkers for diagnosis and therapeutic targets. Moreover, they are suggested to be adequate predictors for cancer prediction. Conclusive evidence proves that CRISPR/Cas system can be applied to target small non-coding RNAs. However, the majority of studies have highlighted the application of the CRISPR/Cas system for targeting protein-coding regions. In this review, we specifically discuss diverse applications of CRISPR-based tools for probing miRNA gene function and miRNA-based therapeutic involvement in different types of cancers.
Hybridization may endanger the rare North Apennine endemic Cirsium bertolonii
Authors: Michálková Ester , Šmerda Jakub , Plačková Klára , Knoll Aleš , Bureš Petr 
Published: May 2023

AbstractWe examined populations of North Apennine stenoendemicsCirsium bertoloniiin the Apuan Alps and Tuscan-Emilian Apennines and found individuals morphologically shifted to co-occurringC. acaulonorC. erisithales. Hybrid status of these intermediates was confirmed by flow cytometry, morphometrics and amplified fragment length polymorphism (AFLP). We interpreted these hybrids taxonomically asCirsium ×sagrense(C. acaulon × C. bertolonii) andC. ×abetonense(C. bertolonii × C. erisithales). Estimated genome size (2C) was 2244 ± 31 Mbp forC. ×sagrenseand 2152 ± 99 Mbp forC. ×abetonense. Their genomic GC content was 38.95 ± 0.35% and 38.77 ± 0.26%, respectively. Diploid chromosome number 2n = 34 was counted forC.bertolonii, and the previously reported 2n = 12 needs to be considered erroneous. We foundC. bertoloniito be a gynodioecious species (like many otherCirsiumspecies) that is not reproductively isolated by ploidy level or chromosome number from co-occurring congeners. The relatively frequent occurrence ofC. ×sagrensein Monte Sagro (locus classicusofC. bertolonii) and the prevalence ofC. ×abetonensein Alpe Tre Potenze suggest that hybridization occurs repeatedly inC. bertolonii, as also confirmed by older herbarium specimens.C. ×abetonenseproduces ripe achenes and F2 hybrids or backcrosses, as some otherCirsiumhybrids do. Genetic erosion/swamping via interspecific hybridization can therefore pose a risk to the genetic integrity ofC. bertolonii, as it does for some other narrowly endemic high-mountainCirsiumspecies in Europe.
Bacterial communities along parrot digestive and respiratory tracts: the effects of sample type, species and time
Authors: Schmiedová Lucie , Černá Kateřina , Li Tao , Těšický Martin , Kreisinger Jakub , Vinkler Michal 
Published: May 2023

AbstractDigestive and respiratory tracts are inhabited by rich bacterial communities that can vary between their different segments. In comparison with other bird taxa with developed caeca, parrots that lack caeca have relatively lower variability in intestinal morphology. Here, based on 16S rRNA metabarcoding, we describe variation in microbiota across different parts of parrot digestive and respiratory tracts both at interspecies and intraspecies levels. In domesticated budgerigar (Melopsittacus undulatus), we describe the bacterial variation across eight selected sections of respiratory and digestive tracts, and three non-destructively collected sample types (faeces, and cloacal and oral swabs). Our results show important microbiota divergence between the upper and lower digestive tract, but similarities between respiratory tract and crop, and also between different intestinal segments. Faecal samples appear to provide a better proxy for intestinal microbiota composition than the cloacal swabs. Oral swabs had a similar bacterial composition as the crop and trachea. For a subset of tissues, we confirmed the same pattern also in six different parrot species. Finally, using the faeces and oral swabs in budgerigars, we revealed high oral, but low faecal microbiota stability during a 3-week period mimicking pre-experiment acclimation. Our findings provide a basis essential for microbiota-related experimental planning and result generalisation in non-poultry birds.
Vessel size as a marker of survival in estrogen receptor positive breast cancer
Authors: Milosevic Vladan , Edelmann Reidunn J. , Winge Ingeborg , Strell Carina , Mezheyeuski Artur , Knutsvik Gøril , Askeland Cecilie , Wik Elisabeth , Akslen Lars A. , Östman Arne 
Published: May 2023

Abstract
Purpose
Angiogenesis is crucial for tumor growth and is one of the hallmarks of cancer. In this study, we analyzed microvessel density, vessel median size, and perivascular a-SMA expression as prognostic biomarkers in breast cancer.

Methods
Dual IHC staining was performed where alpha-SMA antibodies were used together with antibodies against the endothelial cell marker CD34. Digital images of stainings were analyzed to extract quantitative data on vessel density, vessel size, and perivascular alpha-SMA status.

Results
The analyses in the discovery cohort (n = 108) revealed a statistically significant relationship between large vessel size and shorter disease-specific survival (p = 0.007, log-rank test; p = 0.01, HR 3.1; 95% CI 1.3–7.4, Cox-regression analyses). Subset analyses indicated that the survival association of vessel size was strengthened in ER + breast cancer. To consolidate these findings, additional analyses were performed on a validation cohort (n = 267) where an association between large vessel size and reduced survival was also detected in ER + breast cancer (p = 0.016, log-rank test; p = 0.02; HR 2.3, 95% CI 1.1–4.7, Cox-regression analyses).

Conclusion
Alpha-SMA/CD34 dual-IHC staining revealed breast cancer heterogeneity regarding vessel size, vessel density, and perivascular a-SMA status. Large vessel size was linked to shorter survival in ER + breast cancer.
Chatbots and messaging platforms in the classroom: An analysis from the teacher’s perspective
Authors: Merelo Juan J. , Castillo Pedro A. , Mora Antonio M , Barranco Francisco , Abbas Noorhan , Guillén Alberto , Tsivitanidou Olia 
Published: May 2023

AbstractMessaging platforms are applications, generally mediated by an app, desktop program or the web, mainly used for synchronous communication among users. As such, they have been widely adopted officially by higher education establishments, after little or no study of their impact and perception by the teachers. We think that the introduction of these new tools and the opportunities and challenges they have needs to be studied carefully in order to adopt the model, as well as the tool, that is the most adequate for all parties involved. We already studied the perception of these tools by students, in this paper we examine the teachers’ experiences and perceptions through a survey that we validated with peers, and what they think these tools should make or serve so that it enhances students learning and helps them achieve their learning objectives. The survey has been distributed among tertiary education teachers, both in universitary and other kind of tertiary establishments, based in Spain (mainly) and Spanish-speaking countries. We have focused on collecting teachers’ preferences and opinions on the introduction of messaging platforms in their day-to-day work, as well as other services attached to them, such as chatbots. What we intend with this survey is to understand their needs and to gather information about the various educational use cases where these tools could be valuable. In addition, an analysis of how and when teachers’ opinions towards the use of these tools varies across gender, experience, and their discipline of specialization is presented. The key findings of this study highlight the factors that can contribute to the advancement of the adoption of messaging platforms and chatbots in higher education institutions to achieve the desired learning outcomes.
Why Fly? Prudential Value, Climate Change, and the Ethics of Long-distance Leisure Travel
Authors: Timmer Dick , van der Deijl Willem 
Published: May 2023

AbstractWe argue that the prudential benefits of long-distance leisure travel can justify such trips even though there are strong and important reasons against long-distance flying. This is because prudential benefits can render otherwise impermissible actions permissible, and because, according to dominant theories about wellbeing, long-distance leisure travel provides significant prudential benefits. However, this ‘wellbeing argument’ for long-distance leisure travel must be qualified in two ways. First, because travellers are epistemically privileged with respect to knowledge about what is good for them, they must look critically at their own assessment of the prudential benefits of a trip. Second, the wellbeing argument is unlikely to support prudential arguments for long-distance leisure trips made by frequent flyers.