bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blockchain enabled zero trust based authentication scheme for railway communication networks
Authors: Feng Yuan , Zhong Zhangdui , Sun Xiaofang , Wang Lei , Lu Yunlong , Zhu Yongsheng 
Published: April 2023

AbstractWith the introduction of emerging technologies such as cloud computing, the railway communication network has the characteristics of complex structure and blurred boundaries, which leads to a series of security threats including information leakage and malicious access. Specifically, the third-party cloud services are difficult to be supervised, and network traffic is untrustworthy. To ensure system security, we propose a zero-trust security model in this paper. Then, we introduce blockchain and Merkle tree to build a distributed identity storage scheme for guaranteeing reliable, confidential and efficient data updates, and improving authentication efficiency. Furthermore, the proxy was introduced for two-way authentication with cloud servers, so that internal and external threats could be counteracted. Moreover, reputation assessment mechanism has been adopted to reduce the possibility of nodes accessing malicious cloud services. Performance analysis demonstrated that the proposed security model is able to enhance the security, efficiency and stability of the system, and consequently can guarantee the safety and reliability of railway transportation.
Efficacy and factors influencing outcomes of customized music therapy combined with a follow-up system in chronic tinnitus patients
Authors: Liu Yuehong , Yang Siyi , Wang Yulu , Hu Jiahua , Xie Hongbo , Ni Tianyi , Han Zhao 
Published: April 2023

Backgrounds Tinnitus is a meaningless sound signal perceived by the patients in the absence of auditory stimuli. Due to the complex etiology and unclear mechanism, specific therapies for tinnitus are still in the exploratory stage. In recent years, personalized and customized music therapy has been proposed as an effective method for tinnitus treatment. The aim of this study was to explore the efficacy of customized therapy with a well-designed follow-up system in the treatment of tinnitus through a large sample one arm study and to identify the relevant factors affecting the treatment outcome. Methods The study investigated a total of 615 patients with unilateral or bilateral chronic tinnitus who received personalized and customized music therapy for 3 months. A complete follow-up system was designed by the professionals. Questionnaires of Tinnitus Handicap Inventory (THI), Hospital Anxiety and Depression Scale (HADS) and Visual Analogue Scale (VAS) were used to evaluate the therapeutic effects and relevant factors affecting the efficacy of therapy. Results The results showed a decreasing trend in THI and VAS scores after 3 months of therapy, with statistically significant differences between pre- and post-therapy time points ( P < 0.001). All patients were divided into 5 groups according to THI scores, and the mean reduction score in catastrophic, severe, moderate, mild and slight group was 28, 19, 11, 5, 0 respectively. The proportion of tinnitus patients with anxiety was higher than that with depression (70.57% and 40.65%, respectively), and there were statistically significant differences between HADS-A/D scores pre- and post-therapy. Binary logistic regression showed that the baseline of THI, VAS scores, the duration of tinnitus and the state of anxiety prior to therapy were significant influencing factors of therapeutic efficacy. Conclusions The magnitude of reduction in THI scores after music therapy depended on the severity of the patients’ tinnitus, the higher the initial THI scores, the greater the potential for improvement in tinnitus disorders. Music therapy also reduced the anxiety and depression levels of tinnitus patients. Therefore, personalized and customized music therapy with a comprehensive follow-up system may be an effective treatment option for chronic tinnitus patients. Graphical Abstract
A study on the construction of knowledge graph of Yunjin video resources under productive conservation
Authors: Lu Lu , Liang Xu , Yuan Gaoteng , Jing Lulu , Wei Chen , Cheng Chen 
Published: April 2023

Abstract
Nanjing Yunjin, a highly representative Chinese silk weaving handicraft, was included in the Representative List of Intangible Cultural Heritage of Humanity in 2009. However, due to modern silk weaving technology advancements, aesthetic style evolution, and inadequate public recognition of Yunjin culture, the art faces a decline in market recognition and practitioners, posing a risk to its preservation. Addressing this issue necessitates product innovation, efficient knowledge storage, management, and utilization, and enhancing public cultural identity for Yunjin. Following the government’s “productive conservation” concept for intangible cultural heritage (ICH) projects in the handicraft category, this study uses Yunjin video resources as the primary data source. It constructs a domain knowledge graph (DKG) using an ontological approach to effectively and systematically preserve Yunjin knowledge. Furthermore, the study leverages Neo4j network topology to reveal intricate and diverse relationships within Yunjin knowledge, uncovering rich cultural connotations. Lastly, Cypher is employed for semantic queries, graph visualization, and domain expert evaluation. Evaluation results indicate that the constructed Yunjin DKG meets quality standards, supporting the development of products that align with market aesthetics while preserving Yunjin’s intrinsic cultural values. This approach fosters a complementary relationship between economic benefits and ICH. Additionally, the Yunjin DKG application presents a technical path for knowledge interconnection, integration, and discovery within ICH projects in the handicraft category.
Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment
Authors: Zhang Dongdong , Sun Yixin , Lei Min , Wang Yue , Cai Chengfu 
Published: April 2023

Abstract
Background
Drug-induced hearing loss (DIHL) is very common, and seriously affects people's happiness in life. RG108 is a small molecule inhibitor. RG108 is protective against DIHL. Our purpose is to probe the incidence of RG108 on cisplatin-induced ototoxicity.

Materials and methods
In our research, the ototoxicity of RG108 was investigated in HEI-OC1. We observed under the microscope whether RG108 had an effect on cisplatin-induced cochlear hair cells. RNA-seq experiments were further performed to explore possible gene ontology (GO) and pathways. ROS assay was applied to supervisory the effect of RG108 on oxidative harm of auditory cells. In auditory cells, RG108 was tested for its effects on apoptosis-related proteins by Western blotting (WB).

Results
GO analysis showed that RG108 associated with apoptosis. KEGG analysis shows RG108 may act on PI3K-AKT signaling pathway (PASP) in hearing loss. BIOCARTA analysis showed that RG108 may affect oxidative stress by activating NRF2 pathway. ROS ascerted that RG108 could rescue oxidative harm in HEI-OC1. RG108 rescued cisplatin-induced significant increase in Bax and significant decrease in BCL2. RG108 attenuates cisplatin-induced cochlear apoptosis through upregulated phosphorylated PI3K and phosphorylated AKT and down-regulated caspase3. MTT experiments showed that both PI3K and AKT inhibitors could significantly rescue the damage caused by cisplatin to HEI-OC1. RG108 significantly increases the level of NRF2/HO-1/NQO1 in cisplatin-induced cells.

Conclusion
Overall, these results provide evidence that NRF2/PI3K-AKT axis may mediate RG108 in the treatment of DIHL, which provide a broader outlook on drug-induced deafness treatment.
Sleep as a vital sign
Authors: Hirschtritt Matthew E. , Walker Matthew P. , Krystal Andrew D. 
Published: April 2023

AbstractSleep is causally linked to the maintenance of every major physiological body system and disturbed sleep contributes to myriad diseases. The problem is, however, is that patients do not consistently, nor spontaneously, report sleep problems to their clinicians. Compounding the problem, there is no standard-of-care approach to even the most rudimentary of sleep queries. As a result, sleep disturbances remain largely invisible to most clinicians, and consequentially, unaddressed for the patient themselves – thereby exacerbating physical and mental health challenges due to unaddressed sleep problems. In this review, we argue that all patients should be routinely screened with a short, readily available, and validated assessment for sleep disturbances in clinical encounters. If the initial assessment is positive for any subjective sleep-related problems, it should prompt a more thorough investigation for specific sleep disorders. We further describe how a program of short and simple sleep health screening is a viable, efficacious yet currently missing pathway through which clinicians can 1) screen for sleep-related problems, 2) identify patients with sleep disorders, 3) rapidly offer evidence-based treatment, and (if indicated) 4) refer patients with complex presentations to sleep medicine specialists.
Do it fast! Early access to specialized care improved long-term outcomes in rheumatoid arthritis: data from the REAL multicenter observational study
Authors: Albuquerque Cleandro Pires , Reis Ana Paula Monteiro Gomides , Vargas Santos Ana Beatriz , Bértolo Manoel Barros , Júnior Paulo Louzada , Neubarth Giorgi Rina Dalva , Radominski Sebastião Cezar , Guimarães Maria Fernanda B. Resende , Bonfiglioli Karina Rossi , L Cunha Sauma Maria de Fátima , Pereira Ivânio Alves , Brenol Claiton Viegas , Henrique Mota Licia Maria , Santos-Neto Leopoldo , Castelar Pinheiro Geraldo Rocha 
Published: April 2023

Abstract
Background
Early rheumatoid arthritis (RA) offers an opportunity for better treatment outcomes. In real-life settings, grasping this opportunity might depend on access to specialized care. We evaluated the effects of early versus late assessment by the rheumatologist on the diagnosis, treatment initiation and long-term outcomes of RA under real-life conditions.

Methods
Adults meeting the ACR/EULAR (2010) or ARA (1987) criteria for RA were included. Structured interviews were conducted. The specialized assessment was deemed “early” when the rheumatologist was the first or second physician consulted after symptoms onset, and “late” when performed afterwards. Delays in RA diagnosis and treatment were inquired. Disease activity (DAS28-CRP) and physical function (HAQ-DI) were evaluated. Student’s t, Mann-Whitney U, chi-squared and correlation tests, and multiple linear regression were performed. For sensitivity analysis, a propensity score-matched subsample of early- vs. late-assessed participants was derived based on logistic regression. The study received ethical approval; all participants signed informed consent.

Results
We included 1057 participants (89.4% female, 56.5% white); mean (SD) age: 56.9 (11.5) years; disease duration: 173.1 (114.5) months. Median (IQR) delays from symptoms onset to both RA diagnosis and initial treatment coincided: 12 (6–36) months, with no significant delay between diagnosis and treatment. Most participants (64.6%) first sought a general practitioner. Notwithstanding, 80.7% had the diagnosis established only by the rheumatologist. Only a minority (28.7%) attained early RA treatment (≤ 6 months of symptoms). Diagnostic and treatment delays were strongly correlated (rho 0.816; p < 0.001). The chances of missing early treatment more than doubled when the assessment by the rheumatologist was belated (OR 2.77; 95% CI: 1.93, 3.97). After long disease duration, late-assessed participants still presented lower chances of remission/low disease activity (OR 0.74; 95% CI: 0.55, 0.99), while the early-assessed ones showed better DAS28-CRP and HAQ-DI scores (difference in means [95% CI]: -0.25 [-0.46, -0.04] and − 0.196 [-0.306, -0.087] respectively). The results in the propensity-score matched subsample confirmed those observed in the original (whole) sample.

Conclusions
Early diagnosis and treatment initiation in patients with RA was critically dependent on early access to the rheumatologist; late specialized assessment was associated with worse long-term clinical outcomes.
Dynamic de novo adipose tissue development during metamorphosis in Drosophila melanogaster
Authors: Tsuyama Taiichi , Hayashi Yusaku , Komai Hanae , Shimono Kohei , Uemura Tadashi 
Published: April 2023

ABSTRACT
Adipose tissue is a central organ for controlling systemic metabolism both in invertebrates and vertebrates. Here, we have investigated the developmental processes of the adult-type fat body (AFB) in Drosophila. We have established genetic tools that allow visualization and genetic manipulations of cells in the AFB lineage from early in metamorphosis. We identified precursor cells that give rise to the AFB and delineated dynamic cellular behaviors underlying AFB formation. These precursor cells displayed polarized cell shapes and oriented motility, with emigration from the thorax and subsequent dispersal to the abdomen and head. After the migration period, these cells adhered to each other, assembling into the AFB with a sheet-like architecture. Continuous cell proliferation occurred during and after the large-scale migration to achieve appropriate fat tissue mass. Homotypic cell fusion after the sheet formation contributed to the establishment of multinucleated cells in the AFB. We also examined candidate gene functions, and our results argue that ecdysone signaling and the transcription factor Serpent support adult fat body organogenesis.
Increasing Step Frequency Reduces Patellofemoral Joint Stress and Patellar Tendon Force Impulse More at Low Running Speed
Authors: HAGEN MICHIEL , VANMECHELEN ANNA , CLOET EMILE , SELLICAERTS JAN , VAN WELDEN KAAT , VERSTRAETE JESPER , CATELLI DANILO S. , VERSCHUEREN SABINE , VANRENTERGHEM JOS 
Published: April 2023

ABSTRACT

Purpose
Patellofemoral pain syndrome and patellar tendinopathy are important running-related overuse injuries. This study investigated the interaction of running speed and step frequency alterations on peak and cumulative patellofemoral joint stress (PFJS) and patellar tendon force (PTF) parameters.

Methods
Twelve healthy individuals completed an incremental running speed protocol on a treadmill at habitual, increased and decreased step frequency. Peak PFJS and PTF, peak rate of PFJS and PTF development, and PFJS and PTF impulse per kilometer (km) were calculated using musculoskeletal modeling.

Results
With increasing running speed, peak PFJS (P < 0.001) and PTF (P < 0.001) and peak rate of PFJS (P < 0.001) and PTF (P < 0.001) development increased, whereas PFJS (P < 0.001) and PTF (P < 0.001) impulse per km decreased. While increasing step frequency by 10%, the peak PFJS (P < 0.001) and PTF (P < 0.001) and the PFJS (P < 0.001) and PTF (P < 0.001) impulse per kilometer decreased. No significant effect of step frequency alteration was found for the peak rate of PFJS (P = 0.008) and PTF (P = 0.213) development. A significant interaction effect was found for PFJS (P < 0.001) and PTF (P < 0.001) impulse per km, suggesting that step frequency alteration was more effective at low running speed.

Conclusions
The effectiveness of step frequency alteration on PFJS and PTF impulse per km is dependent on the running speed. With regard to peak PFJS and PTF, step frequency alteration is equally effective at low and high running speeds. Step frequency alteration was not effective for peak rate of PFJS and PTF development. These findings can assist the optimization of patellofemoral joint and patellar tendon load management strategies.
Nigella sativa L. seed extracts promote wound healing progress by activating VEGF and PDGF signaling pathways: An in vitro and in silico study
Authors: Palanisamy Chella Perumal , Alugoju Phaniendra , Jayaraman Selvaraj , Poompradub Sirilux 
Published: April 2023

Background: A significant area of clinical research is the development of natural wound healing products and the management of chronic wounds. Healing wounds with medicinal plants has been a practice of ancient civilizations for centuries. Nigella sativa L (N. sativa) is a medicinal plant that has several pharmacological properties. Methods: The present study evaluated the wound healing properties of Nigella sativa L. (N. sativa) seed extracts using normal cell lines such as normal human dermal fibroblasts (NHDFs) and human umbilical vein endothelial cells (HUVECs). The expression levels of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) were analyzed through western blot analysis. Furthermore, computational analyses were carried out to screen the potential bioactive compounds for wound healing applications. Results: The results of the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay revealed that, all the tested solvent extracts of N. sativa seeds (including ethanol, ethyl acetate, chloroform, and petroleum ether) did not exert any cytotoxic effects at the tested concentrations. Furthermore, the western blot analysis showed elevated levels of VEGF and PDGF upon treatment with N. sativa seed extracts. Gas chromatography-mass spectrometry (GC-MS) analysis of N. sativa extracts identified 268 phytocompounds. Molecular docking studies revealed that three phytocompounds of N. sativa extracts, including tricyclo[20.8.0.0(7,16)]triacontane, 1(22),7(16)-diepoxy-, adaphostin and obeticholic acid had strong binding affinity with wound healing-related target proteins, showing docking scores ranging from -5.5 to -10.9 Kcal/mol. These compounds had acceptable Absorption, Distribution, Metabolism, and Excretion (ADME) properties. Conclusions: Based on these results, N. sativa seed extracts might possess potential wound healing properties owing to the presence of a wide range of bioactive components.
Floating photovoltaic systems: photovoltaic cable submersion testing and potential impacts
Authors: Rebelo Ricardo , FIALHO Luis , Novais Maria Helena 
Published: April 2023

Background: Floating photovoltaics (FPV) is an emerging technology that is gaining attention worldwide. However, little information is still available on its possible impacts in the aquatic ecosystems, as well as on the durability of its components. Therefore, this work intends to provide a contribution to this field, analysing possible obstacles that can compromise the performance of this technology, adding to an increase of its reliability and assessing possible impacts. The problem under study is related to the potential submersion of photovoltaic cables, that can lead to a degradation of its electrical insulation capabilities and, consequently, higher energy production losses and water contamination. Methods: In the present study, the submersion of photovoltaic cables (with two different insulation materials) in freshwater and artificial seawater was tested, in order to replicate real life conditions, when FPV systems are located in reservoirs or in the marine environment. Electrical insulation tests were carried out weekly to assess possible cable degradation, the physical-chemical characteristics of the water were also periodically monitored, complemented by analysis to detect traces of copper and microplastics in the water. Results: The results showed that the submersion of photovoltaic cables with rubber sheath in saltwater can lead to a cable accelerated degradation, with reduction of its electrical insulation and, consequently, copper release into the aquatic environment. Conclusions: The test results pointed a probable relationship between submersion of cables with rubber outer shell and water freezing temperatures and the occurrence of accelerated degradation of the cable insulation layer. Reduced insulation resistance values were measured in this cable type after the occurrence of such temperatures, both in salt and freshwater, the cable presented visible exterior degradation signs. For this case copper residues were detected in the water.
Assessment of coping with illness among patients with hepatitis C – on example of research in Poland
Authors: Sierpińska Lidia 
Published: April 2023

Introduction: In Poland approximately 2% of the population are infected with HCV. The majority (70-80%) of persons infected with HCV develop chronic hepatitis C which, when untreated, may lead to cirrhosis and/or hepatocellular carcinoma. The skills of coping with stress and acceptance of chronic illness may motivate patients for participation in treatment and leading a health-promoting life style.
Objective: The aim of the study was assessment of coping with illness in patients with chronic hepatitis C.
Materials and Method: The study included 220 adults with chronic hepatitis C, and was conducted by the method of a diagnostic survey using the Polish questionnaire: Brief Method of Assessment of Coping with Illness (Krótka Metoda Oceny Radzenia Sobie z Chorobą - KMORSZCH), the Acceptance of Illness Scale (AIS), and an author-constructed questionnaire.
Results: The examined group of patients with hepatitis C most strongly presented style oriented on emotions and passivity (mean score 1.20), and style focused on problem solving (mean score 1.05), followed by respondents who presented avoidance-oriented style (mean score 0.98), whereas the style focused on seeking the best solution to the problem was most rarely chosen (mean score 0.77). It was found that the more frequently the respondents presented style oriented on experiencing emotions and passivity, to the significantly lower degree they accepted their illness. Patients with higher education significantly more often presented style focused on seeking the best solution to the problem (p<0.045),while those with the lowest level of education significantly more frequently were oriented on experiencing emotions and passivity (p<0.001). Rural inhabitants significantly more often presented style oriented on experiencing emotions and passivity (p<0.002). The remaining independent variables: gender, age, marital status, number of years of illness, and occupational activity had an insignificant effect on the selection of the style of coping with hepatitis C.
Conclusions: The results of the study confirm the need for psychotherapeutic actions with respect to patients with hepatitis C in order to help them cope with the chronic disease, because they most often chose style oriented on emotions and passivity. Psychological assistance should be provided especially for the group of patients who have difficulty with acceptance of the illness.