bluuebunny/crossref_metadata_2025_split huggingface dataset:
Base‐Controlled Palladium‐Catalyzed Intramolecular ‘One Substrate ‐ Five Reactions’ of 5‐Benzyl‐1‐(2‐halobenzyl)‐2‐phenyl‐1H‐pyrazol‐3(2H)‐ones
Authors: Liu Can , Zhu Xianjin , Liu Yong , Yang Haijun , Fu Hua 
Published: January 2023

AbstractAchieving site‐selectivity and chemoselectivity is enormously challenging for substrates with multi‐reactive sites in organic reactions. One kind of model substrates, 5‐benzyl‐1‐(2‐halobenzyl)‐2‐phenyl‐1H‐pyrazol‐3(2H)‐ones with six reactive sites were chosen as the examples to probe their intramolecular four kinds of five reactions including C(sp3)−H arylation, C(sp2)−H arylation, reductive Heck reaction, and domino Heck reaction/alkylation of aryl C(sp2)−H bonds through variation of the reaction conditions. Screening of the reaction conditions showed that the different bases controlled the palladium‐catalyzed intramolecular site‐selectivity and chemoselectivity of the substrates: (i) Cesium carbonate (Cs2CO3) promoted the benzyl C(sp3)−H arylation of the substrates providing dihydropyrazolo[1,5‐b]isoquinolin‐2(1H)‐ones at 100 °C, and isomerization of the dihydropyrazolo[1,5‐b]isoquinolin‐2(1H)‐ones gave isoquinoline derivatives at a higher temperature (140 °C); (ii) Sodium acetate (NaOAc) mediated the aryl C(sp2)−H arylation of the substrates affording seven‐membered biphenyl N‐heterocycles; (iii) Sodium dichloroacetate (Cl2HCCO2Na) facilitated occurrence of the reductive Heck reaction of the substrates affording 1H‐pyrazolo[5,1‐a]isoindol‐2(8H)‐ones; (iv) Sodium trifluoroacetate (F3CCO2Na) assisted performance of the domino Heck reaction/aryl C(sp2)−H alkylation of the substrates leading to the spiro heterocycles. The ‘one substrate ‐ multiple reactions ‐ multiple products’ strategy greatly reduces cost, increases diversity of products, provides more opportunity for screening of pharmaceutical molecules, and enriches modern organic synthetic chemistry.
The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long‐term follow‐up
Authors: Lashen Ayat G. , Toss Michael S. , Mongan Nigel P. , Green Andrew R. , Rakha Emad A. 
Published: January 2023

AbstractBackgroundThe routine assessment of progesterone receptor (PR) expression in breast cancer (BC) remains controversial. This study aimed to evaluate the role of PR expression in luminal BC, with emphasis on the definition of positivity and its prognostic significance as compared to Ki67 expression.MethodsA large cohort (n = 1924) of estrogen receptor (ER)‐positive/HER2‐negative BC was included. PR was immunohistochemically (IHC) stained on full face sections and core needle biopsies (CNB) where the optimal scoring cutoff was evaluated. In addition, the association of PR with other clinicopathological factors, cellular proliferation, disease outcome, and response to adjuvant therapy were analyzed.ResultsAlthough several cutoffs showed prognostic significance, the optimal cutoff to categorize PR expression into two clinically distinct prognostic groups on CNB was 10%. PR negativity showed a significant association with features of aggressive tumor behavior and poor outcome. Multivariate analyses indicated that the association between PR negativity and poor outcome was independent of tumor grade, size, node stage, and Ki67. PR negativity showed independent association with shorter survival in patients who received endocrine therapy whereas Ki67did not.ConclusionPR IHC expression provides independent prognostic value superior to Ki67. Routine assessment of PR expression in BC using 10% cutoff in the clinical setting is recommended.Plain Language Summary

In this study, we have established an optimal approach to determine the prognostic value of progesterone receptor expression in estrogen receptor‐positive breast cancer patients.

To do this, the levels of progesterone receptor were measured in a large cohort of estrogen receptor‐positive breast cancer patients.

We have refined the definition of progesterone receptor positivity in estrogen receptor‐positive breast cancer.

We show that progesterone receptor expression adds prognostic and predictive value of endocrine therapy in estrogen receptor‐positive breast cancer patients, and our results show that the absence of progesterone receptor is associated with poorer outcomes independent of tumor grade, size, node stage, and Ki67 expression.
Sentiment analysis based on frequency of color names on social media
Authors: Guo Boshuo , Westland Stephen , Lai Peihua 
Published: January 2023

AbstractThis study explores the temporal changes in sentiment associated with eight color names over an 18‐month period at four observation points. We focus on the valence aspect of sentiment. We collected four datasets, each separated by 6 months, and each containing 18 000 mentions of each of the eight color names in English from Twitter users around the world. We calculated the weighted average sentiment score of each instance when a color is mentioned. We find that purple and pink are the most positive in average sentiment score in all observation points, whereas brown, red, and orange are ranked as the lowest in average sentiment score. In terms of relative rank in sentiment value associated with the color names, we find the three consecutive datasets of July 2020, January 2021 and July 2021 are more consistent with one another, while the January 2022 dataset is more different from the earlier three datasets. This finding indicates that the temporal consistency in color‐associated sentiment might maintain within 1 year, while evolve and show more difference in a longer timeline. This study is useful to marketing professionals by revealing that color names are associated with sentiment and that these associations can be monitored using social media data regularly. We suggest that marketers can use our method to analyse the color‐associated sentiment of color names regularly, maybe on an annual basis, in order to choose color names wisely.
Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression
Authors: Pérez‐López Faustino R. , Yuan Junhua , Sánchez‐Prieto Manuel , López‐Baena María T. , Pérez‐Roncero Gonzalo R. , Varikasuvu Seshadri Reddy 
Published: January 2023

AbstractAimsThis systematic review and meta‐analysis examined maternal and cord blood betatrophin levels in pregnant women with gestational diabetes mellitus (GDM) and normoglycemic controls.Material and MethodsPubMed, Cochrane Library, Embase, LILACS, WangFang, and China National Knowledge Infrastructure were searched for literature from inception until May 2022. The primary outcomes were maternal and cord blood betatrophin levels. A random‐effect meta‐analysis was used to estimate the pooled results. The mean differences (MDs) or standardised MDs (SMD) and their 95% confidence intervals (CIs) were calculated. I2 tests were used to evaluate the heterogeneity. The quality of studies was evaluated using the Newcastle–Ottawa Scale.ResultsBetatrophin levels were reported in 22 studies with a total of 3034 pregnant women, and in seven studies including cord blood from 456 infants. Women with GDM display higher betatrophin levels than the normoglycemic controls (SMD = 0.85, 95% CI: 0.38–1.31) during the second half of the pregnancy. The sensitivity analysis indicated that no single study had significantly influenced the betatrophin overall outcomes. There was heterogeneity between the studies as evidenced by high I2 values. Meta‐regression analysis indicated a significant regression coefficient for maternal betatrophin and glycosilated haemoglobin. There was no significant difference in cord blood betatrophin in infants from women with and without GDM (SMD = 0.34, 95% CI: −0.15–0.83). Women with GDM also had significantly higher insulin, glucose, glycosylated haemoglobin, HOMA‐IR, LDL‐cholesterol, HDL‐cholesterol, triglycerides, and body mass index compared with the normoglycemic controls.ConclusionsMaternal betatrophin levels were higher in women with GDM than in the normoglycemic controls. There was no difference in cord blood betatrophin.Systematic Review RegistrationPROSPERO CRD42022311372.
Crystal Structure, Characterization, and Luminescence Properties of Mn4+‐Doped K3Nb2O4F5
Authors: Zimmerhofer Fabian , Seibald Markus , Stoll Christiane , Baumann Dominik , Wurst Klaus , Huppertz Hubert 
Published: January 2023

AbstractIn this paper, we present the high‐pressure/high‐temperature synthesis and characterization of the potassium fluoridooxidoniobate K3Nb2O4F5. Single‐crystal analysis revealed that the phase crystallizes in the trigonal space group
m (hR18) with a=5.799(2), c=21.371(4) Å, V=622.4(4) Å3 and Z=3 at T=299 K exhibiting a structure type closely related to that of Ba2RbFe2F9. The assignment of the anion positions to oxygen and fluorine is based on crystallographic data and BLBS/CHARDI calculations. Further characterization via EDX spectroscopy was carried out, corroborating the ratio of K to Nb. Doping of the title compound with Mn4+ was achieved in a secondary step using a ball‐mill, resulting in a red phosphor material, which was additionally analyzed by luminescence spectroscopy. The emission maximum is located at λmax=630 nm.
Assessing the informational content of card transactions for nowcasting retail trade: Evidence for Latvia
Authors: Brinke Anete , Fadejeva Ludmila , Siliverstovs Boriss , Vilerts Kārlis 
Published: January 2023

AbstractWe use a novel card transaction data maintained at the Central Bank of Latvia to assess their informational content for nowcasting retail trade in Latvia. During the COVID‐19 pandemic in Latvia, the retail trade turnover dynamics underwent drastic changes reflecting the various virus containment measures introduced during three separate waves of the pandemic. We show that the nowcasting model augmented with card transaction data successfully captures the turbulence in retail trade turnover induced by the COVID‐19 pandemic. The model with card transaction data outperforms all benchmark models in the out‐of‐sample nowcasting exercise and yields a notable improvement in forecasting metrics. We conduct our nowcasting exercise in forecast‐as‐you‐go manner or in real‐time squared; that is, we use real‐time data vintages, and we make our nowcasts in real time as soon as card transaction data become available for the target month.
Macro‐financial effects of monetary policy easing
Authors: Apostolakis George N. , Giannellis Nikolaos , Papadopoulos Athanasios P. 
Published: January 2023

AbstractThis study examines the impact of Fed monetary policy shocks on financial stress, inflation, and output growth, considering several advanced and emerging economies. To that end, it uses shadow rates as a proxy measure of unconventional monetary policy actions and a financial stress index as an indicator of financial instability. We apply a global vector autoregressive model and present the outcome of impulse response functions and forecasts of macroeconomic and financial stress variables. Our results show that US output and inflation are positively affected in response to a domestic negative monetary policy shock, whereas financial stress is unresponsive to the same shock. This policy also has international effects, as we find significant spillovers with the US interest rate shock impacting inflation abroad. The findings of this study are useful to policymakers and investors.
Recreational cannabis and opioid distribution
Authors: Raman Shyam , Maclean Johanna Catherine , Bradford W. David , Drake Coleman 
Published: January 2023

AbstractTwenty‐one U.S. states have passed recreational cannabis laws as of November 2022. Cannabis may be a substitute for prescription opioids in the treatment of chronic pain. Previous studies have assessed recreational cannabis laws' effects on opioid prescriptions financed by specific private or public payers or dispensed to a unique endpoint. Our study adds to the literature in three important ways: by (1) examining these laws' impacts on prescription opioid dispensing across all payers and endpoints, (2) adjusting for important opioid‐related policies such as opioid prescribing limits, and (3) modeling opioids separately by type. We implement two‐way fixed‐effects regressions and leverage variation from eleven U.S. states that adopted a recreational cannabis law (RCL) between 2010 and 2019. We find that RCLs lead to a reduction in codeine dispensed at retail pharmacies. Among prescription opioids, codeine is particularly likely to be used non‐medically. Thus, the finding that RCLs appear to reduce codeine dispensing is potentially promising from a public health perspective.
Serum leptin levels in patients with chronic kidney disease and hypertensive heart disease: An observational cross‐sectional study
Authors: Ofori Emmanuel K. , Adekena Christian N. , Boima Vincent , Asare‐Anane Henry , Yorke Ernest , Nyarko Eric N. Y. , Mohammed Bismark N. , Quansah Emmanuel , Jayasinghe Sisitha U. , Amanquah Seth D. 
Published: January 2023

AbstractBackground and AimAdipocytes secrete a peptide hormone called leptin, which plays a crucial role in controlling appetite and energy expenditure. Alterations in leptin concentrations are associated with CKD‐related cardiovascular problems such as hypertensive heart disease (HHD). Despite the link, data on the precise function of leptin in people with CKD and HHD is scant.MethodsAn observational cross‐sectional study involving a total of 108 participants (72 CKD patients with HHD and 36 healthy controls). Their demographic and anthropometric information was collected using a standardized questionnaire. Certain clinical measures such as blood pressure and body mass index (BMI) were assessed. Fasting blood samples were analyzed for levels of plasma glucose (FPG), lipids, creatinine, and leptin. Data were analyzed with SPSS v23.ResultsLeptin, FPG, creatinine and triglyceride levels were all significantly higher in CKD patients with HHD compared to controls (p < 0.01 for all). Furthermore, advanced CKD status (being in stage 5), having a 6‐year diagnosis of HHD, being female, having a higher BMI, and elevation in levels of HDL and FPG contributed significantly to the variance in serum leptin levels in the case group (β = 0.37, 0.22, 0.19, 0.18, 0.27, 0.28; p < 0.05 for all). In the control group, the female gender had the biggest unique effect on circulating leptin levels, followed by BMI and eGFR (β = 0.71, 0.34, −0.22; p < 0.01 for all).ConclusionPatients with CKD who also had HHD reported considerably higher circulating leptin levels. Significantly higher blood leptin levels were shown to be associated with CKD stage 5 in the case group. These results are consistent with the role of leptin in the metabolic complexity seen in CKD patients. There needs to be more research into treatments that aim to lower leptin levels in CKD patients with HHD.
Alvarado or RIPASA? Which one do you use to diagnose acute appendicitis?: A cross‐sectional study
Authors: Heiranizadeh Naeimeh , Mousavi Beyuki Seyyed Mohammad Hossein , kargar Saeed , Abadiyan Aryana , Mohammadi Hamid Reza 
Published: January 2023

AbstractBackground and AimsAcute appendicitis is one of the most common causes of lower abdominal pain, which is considered a general surgical emergency worldwide. The present study aimed to compare the diagnostic value of Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) and Alvarado score systems in diagnosing acute appendicitis.MethodsA prospective cross‐sectional study was conducted at Shahid Sadoughi and Shahid Rahnemoon Hospitals in Yazd between September 2020 and February 2020. The statistical population consisted of all of the patients referred to the Accident and Emergency department with right iliac fossa (RIF) pain. All patients were scored using Alvarado and RIPASA scoring system. sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were computed by using SPSS statistical software. An receiver operating characteristic curve were plotted.ResultsIn present study, one hundred suspected patients with appendicitis who underwent appendectomy were evaluated. The mean age of our study population was 25.2 ± 12.1 years, and the gender distribution was 57% males and 43% females. The sensitivity, specificity, PPV and NPV of RIPASA were 86.6%, 66.7%, 92.2%, and 52.2%, respectively. The sensitivity, specificity, PPV and NPV of Alvarado score were 67.1%, 72.2%, 91.7%, 32.5%, respectively. The diagnostic accuracy was 68% for Alvarado score and 83% for RIPASA. The area under the curve for RIPASA (0.87) was more than that for Alvarado score (0.77).ConclusionThe RIPASA score system had higher sensitivity, PPV, NPV, and accuracy than the Alvarado one. It is recommended for the physician and surgeon to evaluate patients with RIF pain using the RIPASA score.
(Glycan Binding) Activity‐Based Protein Profiling in Cells Enabled by Mass Spectrometry‐Based Proteomics
Authors: Vilen Zak , Reeves Abigail E. , Huang Mia L. 
Published: January 2023

AbstractThe presence of glycan modifications at the cell surface and other locales positions them as key regulators of cell recognition and function. However, due to the complexity of glycosylation, the annotation of which proteins bear glycan modifications, which glycan patterns are present, and which proteins are capable of binding glycans is incomplete. Inspired by activity‐based protein profiling to enrich for proteins in cells based on select characteristics, these endeavors have been greatly advanced by the development of appropriate glycan‐binding and glycan‐based probes. Here, we provide context for these three problems and describe how the capability of molecules to interact with glycans has enabled the assignment of proteins with specific glycan modifications or of proteins that bind glycans. Furthermore, we discuss how the integration of these probes with high resolution mass spectrometry‐based technologies has greatly advanced glycoscience.
Accessory cavitated uterine malformation: Enhancing awareness about this unexplored perpetrator of dysmenorrhea
Authors: Mondal Rana , Bhave Priya 
Published: January 2023

AbstractAn accessory cavitated uterine mass (or malformation) (ACUM) is an isolated cystic uterine lesion located at the lateral aspect of the myometrium just below the insertion of the round ligament. Often the source of severe dysmenorrhea and pelvic pain, this condition is classified as a Müllerian abnormality. Understanding ACUMs, recognizing their clinical appearance, diagnosing an ACUM with ultrasound or magnetic resonance imaging, and advising patients about conservative, medicinal, and surgical treatment options is important to all clinicians. Although ACUM primarily presents with severe dysmenorrhea but can have other clinical symptoms, we have provided a few sample cases to help clinicians prepare for ACUM encounters. We also reviewed the other published literature available on ACUM regarding clinical presentation, etiology, and management. Last but not least, based on our research and the work of others, we offer a set of characteristics that will be useful in diagnosing and treating ACUM. ACUM diagnosis is crucial in clinically suspicious circumstances, and early treatment significantly enhances patients' quality of life.
Mucinous cystadenoma of the renal parenchyma presenting as a Bosniak IIF complex renal cyst
Authors: Nate Takanori , Hatano Koji , Kato Taigo , Kawashima Atsunari , Abe Toyofumi , Fukuhara Shinichiro , Uemura Motohide , Kiuchi Hiroshi , Imamura Ryoichi , Nonomura Norio 
Published: January 2023

IntroductionA primary retroperitoneal mucinous cystadenoma should be surgically resected because of the risk of malignant transformation. However, mucinous cystadenoma of the renal parenchyma is very rare, and preoperative imaging mimics complicated renal cysts.Case presentationA 72‐year‐old woman presented with a right renal mass on computed tomography that was followed up as a Bosniak IIF complicated renal cyst. One year later, the right renal mass gradually increased in size. Abdominal computed tomography showed an 11 × 10 cm mass in the right kidney. A laparoscopic right nephrectomy was performed because cystic carcinoma of the kidney was suspected. Pathologically, the tumor was diagnosed as mucinous cystadenoma of the renal parenchyma. Eighteen months after resection, the disease has not recurred.ConclusionHere, we experienced a case of a renal mucinous cystadenoma as a slowly enlarging Bosniak IIF complex renal cyst.
Estimating worldwide benefits from improved bananas resistant to Fusarium Wilt Tropical race 4
Authors: de Figueiredo Silva Felipe , Kaplan Scott , Tobar Freddy Arturo Magdama , Potts Matthew D. , Martinez Ramon Leonardo Espinel , Zilberman David 
Published: January 2023

AbstractWe assess the economic welfare implications of developing and introducing a gene‐edited banana with resistance against an emerging plant disease, Fusarium oxysporum f.sp. cubense Tropical race 4, on global banana production. Using a model incorporating disease dynamics and diffusion of a technological solution, we find that a 5‐year delay in adoption results in discounted losses of $94 billion. Consumers always lose from delay, while the impact on producers depends on timing and severity of the disease. The results suggest that regulatory delay significantly decreases return on investment from research, and acceptance of a technological solution may depend on the distribution of benefits and costs across stakeholders.
IFNL3/4 polymorphisms as a two‐edged sword: An association with COVID‐19 outcome
Authors: Matic Sanja , Milovanovic Dragan , Mijailovic Zeljko , Djurdjevic Predrag , Sazdanovic Predrag , Stefanovic Srdjan , Todorovic Danijela , Popovic Suzana , Vitosevic Katarina , Vukicevic Vladimir , Vukic Milena , Vukovic Nenad , Milivojevic Nevena , Zivanovic Marko , Jakovljevic Vladimir , Filipovic Nenad , Baskic Dejan , Djordjevic Natasa 
Published: January 2023

AbstractCoronavirus Disease 2019 (COVID‐19) has been ranked among the most fatal infectious diseases worldwide, with host's immune response significantly affecting the prognosis. With an aim to timely predict the most likely outcome of SARS‐CoV‐2 infection, we investigated the association of IFNL3 and IFNL4 polymorphisms, as well as other potentially relevant factors, with the COVID‐19 mortality. This prospective observational case‐control study involved 178 COVID‐19 patients, hospitalized at Corona Center or Clinic for Infectious Diseases of University Clinical Centre Kragujevac, Serbia, followed up until hospital discharge or in‐hospital death. Demographic and clinical data on all participants were retrieved from the electronic medical records, and TaqMan assays were employed in genotyping for IFNL3 and IFNL4 single nucleotide polymorphisms (SNPs), namely rs12980275, rs8099917, rs12979860, and rs368234815. 21.9% and 65.0% of hospitalized and critically ill COVID‐19 patients, respectively, died in‐hospital. Multivariable logistic regression analysis revealed increased Charlson Comorbidity Index (CCI), N/L, and lactate dehydrogenase (LDH) level to be associated with an increased likelihood of a lethal outcome. Similarly, females and the carriers of at least one variant allele of IFNL3 rs8099917 were almost 36‐fold more likely not to survive SARS‐CoV‐2 infection. On the other hand, the presence of at least one ancestral allele of IFNL4 rs368234815 decreased more than 15‐fold the likelihood of mortality from COVID‐19. Our results suggest that, in addition to LDH level, N/L ratio, and CCI, IFNL4 rs368234815 and IFNL3 rs8099917 polymorphisms, but also patients' gender, significantly affect the outcome of COVID‐19.