bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Serum Lactate Dehydrogenase and Uric Acid in Preeclampsia and Eclampsia: Can they Predict Adverse Fetomaternal Outcome?
Authors: Moharana Jayashree Jayabharati , Mishra Ruchi , Nayak Ajit Kumar 
Published: August 2023

Background:
Hypertensive disorders of pregnancy affect 3%–5% of all pregnancies, contributing immensely to maternal morbidity and mortality. According to the WHO, the incidence of deaths due to preeclampsia and eclampsia in developing and developed countries is 2.8% and 0.4%, respectively. Lactate dehydrogenase (LDH) and uric acid are good predictors of disease severity.

Aim:
This study aims to determine the fetomaternal outcome in relation to abnormal serum levels of LDH and uric acid.

Materials and Methods:
A cross-sectional study was carried out in 1200 patients with preeclampsia and eclampsia at a tertiary care center over 2 years. Patients were divided into – Group A: patients with normal LDH (≤300 IU/L) and uric acid (<6 mg/dl) (n = 300). Group B: patients with abnormal LDH and uric acid (n = 900), who were further divided into mild and severe preeclampsia and eclampsia. Abnormal serum values were stratified into groups for easier comparison. The results were compared in terms of maternal and perinatal outcomes.

Results:
The incidence of preeclampsia and eclampsia in our study is 3.14% and 1.57%, respectively. Significant changes in LDH and uric acid were associated with increased severity of the disease (LDH – 1116.94 ± 4.78; uric acid – 9.2 ± 2.89). Higher incidence of maternal and fetal complications was seen with severe preeclampsia and eclampsia with LDH >800 IU/L and uric acid >6 mg/dl.

Conclusion:
Standard antenatal follow-up should be carried out for early detection and prevention of preeclampsia, with strict monitoring of serum uric acid level and LDH. This may reduce the maternal and fetal complications due to preeclampsia.
Serum Vitamin D Levels and Dry Eye Disease in Postmenopausal Women: A Case–Control Study at a Tertiary Care Center in Rural Haryana
Authors: Malik Diksha , Garg Renu , Sethi Sumita , Mahendru Rajiv , Singh Sanjeet 
Published: August 2023

Background:
Despite the high prevalence of Vitamin-D insufficiency and high susceptibility to dry eye disease (DED) in postmenopausal women (PMW), correlation between DED and Vitamin D has not been explored in PMW in any Indian study.

Aims and Objectives:
To explore the correlation between serum Vitamin D levels in PMW with and without DED, in a hospital-based population in rural Haryana.

Materials and Methods:
Subjective (ocular surface disease index [OSDI] questionnaire) and objective clinical tests were undertaken for DED diagnosis. 25(OH) Vitamin D was measured in serum using enzyme-linked immunosorbent assay; insufficient (10–30 ng/ml) and deficient (<10 ng/ml). Descriptive statistics were analyzed by mean ± standard deviation for continuous and frequencies for the categorical variables; Student’s t-test used to find out mean difference in Vitamin D levels; P < 0.05 was considered statistically significant.

Results:
One hundred and forty PMW (60.1 ± 5.32 years) were included; Group-A (Controls; no DED; n: 70); Group-B (Cases; DED diagnosed by OSDI scores; n: 70); Subgroup-B1 (clinical tests negative; n: 30) and B2 (clinical tests positive; n: 40). There was no statistically significant difference in OSDI scores between B1 and B2. Significantly lower mean Vitamin D levels were found in cases (14.36 ± 4.08 ng/ml) as compared to controls (19.19 ± 6.4 ng/ml) (P = 0.001) and in B2 (13.15 ± 3.51 ng/ml) as compared to B1 (15.57 ± 4.66 ng/ml) (P = 0.01).

Conclusion:
There were significantly low levels of Vitamin-D in clinically established DED. Evaluating Vitamin D levels as a part of the dry eye workup in PMW is recommended. OSDI scores were not aligned with the clinical test scores; questionnaire-based tests alone may not be sufficient for diagnosing DED.
Diagnostic Efficacy of Chest CT Imaging in Diagnosis of COVID-19 Cases Based on Duration of Symptoms
Authors: Trivedi S , Javed NB , Desai RS , Issar P 
Published: August 2023

ABSTRACT

Background:
Chest computed tomography (CT) imaging provides results more rapidly and with higher sensitivity than reverse transcription polymerase chain reaction in diagnosis of COVID-19.

Aim:
To evaluate diagnostic efficacy of chest CT imaging in diagnosis of COVID-19 cases based on age and duration of symptoms.

Materials and Methods:
A retrospective study conducted during December 2020 to June 2021 in a tertiary care hospital, India. Total 495 patients with typical clinical symptoms of COVID-19, reverse transcription polymerase chain reaction positive for COVID-19 and had undergone chest CT imaging were included. Descriptive statistical analysis was performed for all the variables. Receiver operating characteristic curve analysis was used to determine threshold value of chest CT severity score (CT_SS) based on duration of symptoms and age to diagnose COVID-19.

Results:
Mean age of patients was 61.86 ± 10.77 years and 367 (71.4%) patients were male. Ground glass opacities were observed in 456 (92.1%) patients and in 332 (67.1%) patients, multilobes were affected. Total CT_SS showed positive correlation with age (r = 0.257) and duration of symptoms (r = 0.625). Total CT_SS >6 after a duration of 2 days of symptoms identified COVID-19 cases with sensitivity 90.8% (95% confidence interval [CI]: 87.5%-93.5%) and specificity 84.6% (95% CI: 76.2%-90.9%). Total CT_SS >11 in patients aged more than 60 years identified COVID-19 cases with sensitivity 47.4% (95% CI: 41.2%-53.6%) and specificity 87.3% (95% CI: 82.3%-91.4%).

Conclusion:
Threshold value of CT_SS determined will help to expedite diagnosis of COVID-19 patients by the clinicians in an early stage especially in India and other developing countries which have a high patient volume and limited health resources.
Cyclin D1 Expression, Clinicopathological Characteristics, and 2-Year Survival Rate of Gastric Cancer in Cipto Mangunkusumo General Hospital
Authors: Cahyanur R , Utari AP , Rahadiani N 
Published: August 2023

ABSTRACT

Background:
Cyclin D1 is a protein that can increase the proliferation of cancer cells. Its expression has been found in various malignancies, including gastric cancer. Cyclin D1 examinations have not been routinely performed for gastric cancer cases in Indonesia. A recent study of cyclin D1 in gastric cancer was associated with lymph node involvement, metastasis, poor prognosis, and a lack of response to platinum chemotherapy.

Aim:
This study aimed to determine the relationships among cyclin D1 expression, clinicopathological features, and 2-year survival rates in gastric cancer.

Materials and Methods:
This retrospective cohort study used medical records and paraffin blocks of patients suffering from gastric cancer at Cipto Mangunkusumo General Hospital, Jakarta, between 2015 and 2020. Data analysis was performed using Statistical Package for the Social Sciences (SPSS) version 20. The data were collected from 39 subjects, most of whom experienced eating disorder (69.23%), weight loss (76.92%), melena (53.85%), and anemia (51.28%). Tumor location was mostly found in the cardia and corpus of the gaster.

Results:
This study found that the proportion of overexpression of cyclin D1 was 30.77%. Cyclin D1 expression was greater in subjects with liver metastases (50% vs. 14.8%, P = 0.04). Cyclin D1 expression was not associated with tumor location, tumor, node, and metastasis (TNM) stage, or histopathological findings. Analysis of the 2-year survival rate did not find any differences between patients with cyclin D1 overexpression and those with cyclin D1 negative.

Conclusions:
Cyclin D1 expression was associated with liver metastases in patients with gastric cancer.
Analysis of Diagnoses of Chest Injuries in a Nigerian Trauma Center
Authors: Okoye OG , Gwaram UA , Olaomi OO , Adamu YB , Apollo DK 
Published: August 2023

ABSTRACT

Background:
Chest injury is one of the most common types of trauma-related injuries accounting for about 10% of trauma admissions in emergency services. The injuries may be immediate, life-threatening, or potentially life-threatening based on diagnosis after initial assessment. This study is intended to analyze the pattern of diagnosis found in chest-injured patients in a trauma center of a developing country.

Methods:
This is a retrospective study carried out in the trauma center of the National Hospital Abuja, Nigeria, between January 2015 and December 2017, as an analysis of the existing trauma registry. Data procession was done using SPSS version 24.0. Results were presented in tables and figures.

Results:
A total of 637 patients’ data was studied, male to female ratio of 3.58 and mean age of 34.18 ± 11.34 years. More patients sustained isolated chest injury (59.5%) and blunt chest injury (78%). The most frequent diagnosis was chest wall soft tissue injury (CWSTI) (46.6%) despite the exclusion of minor chest wall injuries who did not require any form of observation. Haemothorax and rib fractures were the next most common diagnoses after CWSTI constituting 13.5% and 8.7%, respectively, while flail chest and aortic injuries were the least comprising 0.6% and 0.2%, respectively. The commonest associated injuries were traumatic brain injury (11.3%), extremity fractures (11.1%), and abdominal injuries (7.8%). Penetrating injuries were more significantly associated with male gender and isolated chest injuries (P < 0.001).

Conclusion:
Chest wall soft tissue injuries constitute a large proportion of chest injuries seen in our setting. Despite its relatively low importance in the medical literature, it should be given attention in resource-poor settings in order to minimize missed significant injuries in the absence of diagnostic facilities. Therefore, high index of suspicion and low threshold for observation should be practiced in this group of patients.
The Effect of Kinesio Taping on Acute Pain, Breastfeeding behavior and Comfort Level in Women with Cesarean Section: A Randomized Controlled Trial
Authors: Uzunkaya-Öztoprak P , Koç G , Özyüncü Ö 
Published: August 2023

ABSTRACT

Background:
Kinesio taping is used to provide rehabilitation after surgical operations.

Aim:
The aim of this study is to determine the effect of kinesio taping (KT) on acute pain, breastfeeding behavior, and comfort level in women with cesarean section.

Subjects and Methods:
This was a randomized, single-blinded study. Women (n = 48) were randomly assigned to KT (n = 24) and control (n = 24) groups. KT was applied to both breasts and rectus abdominis muscles of those in the intervention group at the 8-hour postpartum. VAS (Visual Analogue Scale), LATCH (Breastfeeding Charting System and Documentation Tool), PBSES (Postpartum Breastfeeding Self-Efficacy Scale), and PCS (Postpartum Comfort Scale) were performed on the women in both the intervention and control groups on the 0th, 1st and 2nd postoperative days. Data were analyzed using descriptive statistics, the independent samples t-test, the Chi-square test, and the Friedman test.

Results:
Compared to the control group, the pain level was significantly reduced in the KT group (χ2 = 67,225; P = 0.001), breastfeeding self-efficacy increased (F = 221.940; P = 0.001) and the postpartum comfort level (χ2 = 36.432; P = 0.001) improved.

Conclusion:
In the study, it has been shown that KT has important effects on pain management, breastfeeding success, and increasing comfort level in women with cesarean section compared to the control group and the initial period, and can be used safely.
Optimal Ropivacaine Concentration for Ultrasound-Guided Erector Spinae Plane Block in Patients who underwent Video-Assisted Thoracoscopic Lobectomy Surgery
Authors: Chung HW , Chang H , Hong D , Yun HJ , Chung HS 
Published: August 2023

ABSTRACT

Background:
An ultrasound-guided erector spinae plane block (ESPB) has emerged as an effective way to control postoperative pain and may be a good alternative way to an epidural block. However, relevant research on the appropriate concentration of local anesthetics for an ESPB remains scarce.

Aims:
This study aimed to investigate the optimal concentration of ropivacaine for an ESPB in patients undergoing video-assisted thoracoscopic surgery (VATS).

Methods:
A total of 68 patients who underwent a VATS lobectomy were enrolled. An ipsilateral ultrasound-guided ESPB was performed with three different ropivacaine concentrations as a local anesthetic: 0.189% (G1), 0.375% (G2), and 0.556% (G3). The total amount of perioperative remifentanil administered, patient-controlled analgesia (PCA) applied, and rescue drugs for postoperative analgesia during the 24 h after surgery were acquired, and numeric rating scale (NRS) scores were obtained.

Results:
The total amount of intraoperative remifentanil administered was 7.20 ± 3.04 mcg/kg, 5.32 ± 2.70 mcg/kg, and 4.60 ± 1.75 in the G1, G2, and G3 groups, respectively. G2 and G3 had significantly lower amounts of remifentanil administered than the G1 group (P = 0.02 vs. G2; P = 0.003 vs. G3). The G3 group needed more inotropes than the G1 and G2 groups in the perioperative period (P = 0.045). The NRS scores, PCA, and rescue drug were not significantly different in the three groups.

Conclusion:
The optimal concentration of ropivacaine recommended for an ESPB was 0.375%, which was effective in controlling pain and reducing the intraoperative opioid requirements with minimal adverse reactions such as hypotension.
Comparison of Success, Complication and Satisfaction Rates of TOT and TVT-O Surgical Techniques
Authors: Yalçın K 
Published: August 2023

ABSTRACT

Background:
Two different surgical techniques “inside-out” and “outside-in” have been described for transobturator tape procedure, one of the most preferred methods for the surgical treatment of stress urinary incontinence in the last ten years. This study aimed to compare the success, complication, and patient satisfaction rates related to both techniques in patients who underwent transobturator tape procedure due to stress urinary incontinence in a 21-month period.

Patients and Method:
A total of 71 patients including 46 patients who underwent transobturator tape operation with “outside-in” technique and 25 patients who underwent tension-free vaginal tape obturator operation with “inside-out” technique were involved in this study. Patients were evaluated in aspect of postoperative complications, pelvic examination results, stress test results, satisfaction, and quality of life scales.

Results:
Patients operated with both techniques were similar in terms of age, body mass index 15, and menopausal status. Considering the complication rates, dyspareunia was found to be higher in the group using the inside-out technique (p = 0.002). Operation success rates were similar in the two surgical techniques both in subjective and objective evaluation. In addition, although there were differences between the two groups in terms of patient satisfaction rate and quality of life score, overall satisfaction rates were found to be high.

Conclusion:
Transobturator tape operation is a procedure that provides high success rates in the treatment of stress urinary incontinence regardless of the used technique. Operation success rates, patient satisfaction rates, and postoperative quality of life scores were found to be almost similar in both surgical techniques.
Fingernail form as a Post-Extraction Guide for Selecting the Maxillary Central Incisor Tooth form in the Saudi Arabian Population: A Novel Application of CAD Software
Authors: Joseph AM , Aldhuwayhi SD , Mustafa MZ , Deeban Y , Thakare AA , Joseph A 
Published: August 2023

ABSTRACT

Background:
Human teeth and nails have demonstrated similar factors genetically, embryologically, and morphologically. The fingernail form may be used as a post-extraction guide for selecting the tooth form.

Aim:
To evaluate the correlation between the maxillary left central incisor tooth form with the left index, middle, and ring fingernails in the Saudi Arabian population.

Materials and Methods:
A descriptive cross-sectional study with purposive sampling was done among 200 Saudi participants. The maxillary left central incisor and the left index, middle, and ring fingernail were scanned using an intraoral scanner. The 3D digital images were converted to 3D models. The tooth form (tooth length, tooth width, and tooth shape) and nail form (nail length, nail width, and nail shape) were measured using the CAD software. Pearson’s correlation coefficient and T-test were used for statistical analysis (P < 0.05).

Result:
A significant correlation exists between tooth length and nail length, with a maximum correlation toward index nail length (P = 0.015). A significant correlation exists between tooth width and nail width, with a maximum correlation toward ring nail width (P = 0.002). A significant correlation exists between tooth length and nail length in females with a maximum correlation toward index nail length in females (P = 0.001). The mean percentage of similarity between tooth and nail shape (index, middle, and ring) in males and females shows a highly significant difference between them (P = 0.001). The results indicate that the tooth and nail shape are similar (70 to 90%) based on the criteria set by the software.

Conclusion:
A definite correlation exists between maxillary central incisor tooth form and fingernail form. The fingernail form may be used as a post-extraction guide for selecting the maxillary central incisor tooth form in the Saudi Arabian population.
Efficiency and Clinical Results of Bleomycin Injection in the Treatment of Lymphatic Malformations
Authors: Siki FÖ , Sarikaya M , Gündüz M , Sekmenli T , Köksal Y , Çiftci İ 
Published: August 2023

ABSTRACT

Background:
Lymphatic malformations (LMs) are rare congenital anomalies. The traditional treatment is surgical excision, but intralesional sclerosing agent injection is also preferred as the first-choice treatment because of postoperative frequent recurrences, poor cosmetic results, and high complication rate. We aimed to evaluate the efficacy of sclerosing agent injection used in the treatment of LMs in children.

Materials and Methods:
We retrospectively analyzed the children who were treated for LM between January 2011 and January 2022. The lesion sizes of the patients who were injected with sclerosant (Bleomycin) under sedation anesthesia, measured by ultrasound before and after the treatment, were recorded, and the difference between them was statistically evaluated.

Results:
Fifteen patients were retrospectively analyzed. The mean age was 45.2 ± 14.1 months. Of these, ten (66.6%) were male and five (33.3%) were female (F/M = 1/2). The mean age of male patients was 55 ± 20.1 months; the mean age of female patients was 25.8 ± 11. Seven patients had a single dose, two had twice, and six had three and more. The mean measurable size of macrocystic lesions before treatment was 55.2 ± 28.4 mm; after treatment, it was 23.8 ± 18.2 mm. Although no measurable shrinkage was detected in microcystic lesions, it was observed that the lesion shrank to allow surgical resection. With the statistical analysis, it was seen that there was a statistically significant difference between the dimensions before and after the treatment (P < 0.05) and the sclerosant injection had a great effect on the treatment (R: 0.89).

Conclusion:
Intralesional injection of bleomycin is less effective for microcystic or mixed-type LMs, but provides an effective reduction for a safe surgical procedure. It is an effective treatment for macrocystic lesions.
THE MODERATING ROLE OF PROCUREMENT GOVERNANCE ON THE RELATIONSHIP BETWEEN SUPPLY CHAIN AGILITY AND SERVICE DELIVERY OF THE PUBLIC HEALTH CARE SECTOR IN THE COUNTY GOVERNMENTS OF WESTERN REGION, KENYA.
Authors: Machuki Mogere Kelvin 
Published: August 2023

Supply Chain Management is a crucial activity that entails overseeing the movement of materials form the source, throughput, to the end consumer. However, in this endeavour, there are increased instances of uncertainties i.e. speeds of delivery, flexibility and environmental factors that affect the services rendered to the end consumer. This drives the concept of supply chain agility which focuses on the speeds of response to any changes in the consumer demands. The healthcare sector has undergone significant changes within the past decades. Amidst these changes, attaining efficient and effective healthcare service delivery remains a distant prospect among multiple nations. This study therefore sought to find out the moderating role of procurement governance on the relationship between supply chain agility and service delivery in the Public health care sector in the county governments of the western region. The hypothesis for the study was: - Procurement Governance has no significant influence on the relationship between Supply Chain Agility and Service Delivery of the Public Health care sector in the County Governments of Western Region The study was anchored on three theories, theory of Human Service Delivery, Dynamic Capability Perspectives and Institutional Theory. The study adopted a Positivist research philosophy and a descriptive survey research design and the target population was 284 respondents of the four level 5 county hospitals in the western region. Questionnaires and interview schedules were used for data collection and analyzed using descriptive and inferential statistics. Data was presented using tables, scree plots and scatter plots. The study is of value to researchers and academicians, County government authorities and residents of the four counties. 258 respondents participated in the study and preliminary data checking, screening and cleaning was done. Validity and reliability statistics were done and they indicated that the research instruments were adequate for their purpose. Diagnostic tests were also conducted and none of the variables violated these assumptions. Regression analysis was done for the Supply Chain Agility and service delivery. Supply chain agility accounted for 44.5% of the changes in Service Delivery, but with the introduction of procurement governance as a moderator, the R2 value rose to 59.4% with p˂0.05. This indicated that Procurement Governance was a significant moderator of the relationship. The study recommended that hospitals to should pay attention to three main aspects of procurement governance. First, they should set rules and policies that describe the authoritative position regarding the standards, principles, and objectives of the procurement process. Such standards include transparency and Accountability.
MODEL PEMBELAJARAN APTITUDE TREATMENT INTERACTION (ATI) UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIK SISWA PADA MATERI PROGRAM LINIER DI SMAN 1 PADANG TIJI
Authors: Saputra Hery , Raisna Raisna 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui apakah model pembelajaran ATI (Aptitude Treatment Interaction) dapat meningkatkan kemampuan pemecahan masalah matematik siswa pada materi program linier. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian eksperimen. Populasi penelitian ini adalah kelas XI SMA Negeri 1 Padang Tiji, sementara sampel penelitian ini kelas XI IPA 2 sebagai kelas kontrol dan kelas XI IPA 3 sebagai kelas eksperimen. Sampel penelitian ini dipilih dengan menggunakan teknik cluster sampling. Metode pengumpulan data menggunakan pre test dan post test. Analisis data menggunakan uji perbedaan dua rata-rata. Hasil penelitian menunjukkan bahwa Ada perbedaan yang signifikan model pembelajaran Aptitude Treatment Interaction terhadap kemampuan pemecahan masalah pada materi Program Linier peserta didik kelas XI SMAN 1 Padang Tiji. Hal ini ditunjukkan oleh perhitungan uji perbedaan dua rata-rata diperoleh Ttabel = 2,02 Thitung = 0,34358 maka H­0 ditolak dan Ha diterimaKata kunci: ATI (Aptitude Treatment Interaction), Kemampuan Pemecahan Masalah