bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signatures of r-process elements in kilonova spectra
Authors: Domoto Nanae , Tanaka Masaomi , Wanajo Shinya , Kawaguchi Kyohei 
Published: February 2023

AbstractBinary neutron star (NS) mergers have been expected to synthesize r-process elements and cause electromagnetic radiation called kilonovae. Although r-process nucleosynthesis was confirmed by the observations of GW170817/AT2017gfo, individual elements have not been identified except for strontium. Toward identification of elements in kilonova spectra, we perform radiative transfer simulations in NS merger ejecta. We find that Sr II triplet lines appear in the spectrum, which is consistent with the absorption feature observed in GW170817/AT2017gfo. The synthetic spectrum also shows the strong Ca II triplet lines. Absence of the Ca II line features in GW170817/AT2017gfo implies that the Ca/Sr ratio is < 0.002 in mass fraction, which is consistent with nucleosynthesis for electron fraction ≥ 0.40 and entropy per nucleon (in units of Boltzmann constant) ≥ 25. Identification of absorption lines in near-infrared wavelengths which have not yet been decoded may lead to clarify the abundances synthesized in NS merger ejecta.
Toward an efficient modeling of neutrino-driven winds in binary neutron star mergers
Authors: Gizzi Davide , Rosswog Stephan , O’Connor Evan , Perego Albino , Lundman Christoffer 
Published: February 2023

AbstractWe present a mesh-free, neutrino transport approximation called Advanced Spectral Leakage, designed as a powerful tool for simulations of neutrino-driven winds in binary neutron star mergers with the Smoothed-Particle Hydrodynamics. We post-process a number of snapshots and compare relevant neutrino quantities with respect to computationally more expensive transport approaches. We find that the scheme recovers neutrino luminosities and mean energies within 25% accuracy and is computationally more efficient.
Magnetic fields in galactic binaries and gravitational waves
Authors: Bourgoin A. , Le Poncin-Lafitte C. , Mathis S. , Angonin M.-C. 
Published: February 2023

AbstractThe Laser Interferometer Space Antenna (LISA) mission will observe from space gravitational waves emitted by neutron stars and white dwarfs within galactic binaries. These compact stars can have intense magnetic fields. Therefore, the impact of the magnetic fields on the orbital and the spins evolution of binary systems can potentially be detected by LISA through the GW’s strain. Within the magnetic dipole-dipole approximation, we found that magnetism generates a secular drift of the mean longitude which, in turn, shifts all the frequencies contained in the GW signal. For a quasi-circular orbit, the signal is mainly monochromatic and the magnetic shift is proportional to the product of the magnetic moments and is inversely proportional to the 7/2 power of the semi-major axis. Hence, for a highly magnetic binary system in compact orbit, a non-negligible amount of the frequency measured by LISA might have a magnetic origin.
Exploring Populations of Low Mass Merging Compact Binary Systems with Single Einstein Telescope
Authors: Singh Neha , Bulik Tomasz 
Published: February 2023

AbstractEinstein Telescope (ET), a the future third generation gravitational wave detector will be sensitive to gravitational wave signal down to 1 Hz. We present an algorithm to estimate the parameters of the low mass merging compact binary systems such as localisation, chirp mass, redshift, mass ratios and total mass of the source which are crucial in order to estimate the capability of ET to study various compact binary populations. We analysed the compact binary populations of (i) Pop I and Pop II, (ii) Pop III, and (iii) globular clusters, with single ET.
Physics in Ultra-Strong Magnetic Fields
Authors: Harding Alice K. 
Published: February 2023

AbstractSeveral populations of neutron stars have surface magnetic fields above the critical strength of 4.4 × 1013 G where the electron cyclotron energy equals its rest mass. These include high-field rotation-powered pulsars, X-ray dim isolated neutron stars (XDIN), and magnetars. In such ultra-strong fields, quantum effects in physical processes as well as additional exotic Quantum Electrodynamic processes only occurring at these high field strengths have a significant influence on the emitted radiation. Although very strong magnetic fields play a critical role both inside and outside of neutron stars, I will review primarily processes that operate in the neutron star magnetospheres and how they influence the observed radiation.
A search for optical and near-infrared counterparts of the compact binary merger GW190814
Authors: Thakur Aishwarya Linesh 
Published: February 2023

AbstractWe report on our observing campaign of the compact binary merger GW190814, detected by the Advanced LIGO and Advanced Virgo detectors on August 14th, 2019. This signal has the best localisation of any observed gravitational wave (GW) source, with a 90% probability area of 18.5 deg2, and an estimated distance of ≈240 Mpc. We obtained wide-field observations with the Deca-Degree Optical Transient Imager (DDOTI) covering 88% of the probability area down to a limiting magnitude of w = 19.9 AB. Nearby galaxies within the high probability region were targeted with the Lowell Discovery Telescope (LDT), whereas promising candidate counterparts were characterized through multi-colour photometry with the Reionization and Transients InfraRed (RATIR) and spectroscopy with the Gran Telescopio de Canarias (GTC). We use our optical and near-infrared limits in conjunction with the upper limits obtained by the community to constrain the possible electromagnetic counterparts associated with the merger. A gamma-ray burst seen along its jet’s axis is disfavoured by the multi-wavelength dataset, whereas the presence of a burst seen at larger viewing angles is not well constrained. Although our observations are not sensitive to a kilonova similar to AT2017gfo, we can rule out high-mass (> 0.1 M⊙) fast-moving (mean velocity ≥ 0.3c) wind ejecta for a possible kilonova associated with this merger.
Neutron Star Equation of State Constraints from NICER and Multimessenger Gravitational Wave Observations
Authors: Raaijmakers Geert 
Published: February 2023

AbstractThe dense matter equation of state (EoS), describing the state of matter under the extreme conditions found in neutron stars, is not accurately known. However, significant process has been made in recent years through the emergence of new observational avenues of neutron stars. Firstly, the X-ray timing telescope NICER has delivered two joint mass-radius measurements, for pulsars PSR J0030+0451 and PSR J0740+6620, using pulse profile modeling. Secondly, gravitational wave detections of binary neutron star (BNS) mergers allow for a measurement of the EoS-dependent tidal deformability, as demonstrated in the first detected BNS merger GW170817. Additionally, electromagnetic radiation from the subsequent ultraviolet-optical-infrared transient (the kilonova) originating from the ejected material in GW170817 further probes the binary system and the EoS. We demonstrate how the joint analysis of these multi-messenger observations of neutron stars significantly constrains the dense matter EoS. We then describe, in more detail, a framework to jointly analyse a gravitational wave signal and the accompanying kilonova light curves, focusing on possible future black hole–neutron star (BHNS) mergers. We highlight the potential for multimessenger BHNS to constrain the tidal deformability of the neutron star, thereby increasing our understanding of the dense matter EoS.
A broad-band perspective on circular polarization in radio pulsar observations
Authors: Oswald Lucy S. 
Published: February 2023

AbstractWe investigate the broad-band behaviour of circular polarization in radio pulsar profiles and show the relationship between polarization fraction and what proportion of that polarization is circular, both across frequency, and for a large number of pulsars viewed collectively. The behaviour observed may be explained by pulsar polarization originating from the partially-coherent combination of two linearly-polarized orthogonal modes with different flux spectral indices. (See also the poster in the “supplementary information”.)
Court-packing and democratic decay: A necessary relationship?
Authors: Garcia Holgado Benjamin , Sánchez Urribarri Raúl 
Published: February 2023

AbstractA growing body of literature on the role of courts in democratic backsliding claims that court-packing weakens liberal democracy. However, this is not necessarily the case. The goals of the actors who produce court-packing help to explain why the co-optation of the judiciary can have a substantial negative effect on liberal democracy in some (although not all) cases. In this respect, we distinguish two types of court-packing. First,policy-driven court-packingoccurs when politicians manipulate the composition of courts in order to assure a quick implementation of policies. Although this tends to negatively affect judicial independence, it is not per se a first step towards regime change. Second,regime-driven court-packinghappens when politicians alter the composition of the courts with the goal of eroding democracy. In this case, court-packing’s negative effect on judicial independence has a systemic negative effect on different dimensions of liberal democracy. Relying on a wide range of primary and secondary sources, we conceptualize these two types of court-packing by comparing two cases: Carlos Menem (1989–99) in Argentina, seeking judicial support to carry out pro-market economic reforms, and Hugo Chávez (1999–2013) and Nicolás Maduro (2013–present) in Venezuela, seeking to control the judiciary in the context of democratic backsliding.
Controls on the Salinity of Sedimentary Basinal Fluids Under Constant Chemogravitational Potential Conditions
Authors: Yoshimura Shumpei 
Published: February 2023

AbstractFluids in sedimentary basins exert a crucial influence on various geological phenomena including natural resource formation. Worldwide drilling projects have revealed that the salinity of sedimentary basinal fluids generally increases with depth, irrespective of lithology, age of sediments, or the presence of a halite bed. However, how these vertical salinity variations are produced and what controls the salinity remain unclear. This work examines a new hypothesis that downward‐increasing salinity variations are a natural outcome of the constant chemogravitational potential condition. In a static environment, the salinity is distributed such that the chemogravitational potential of the solute is constant with depth. Once formed, such a distribution would be maintained because no further migration of the solute would occur. To test the hypothesis, a constant chemogravitational potential distribution model was constructed for NaCl–H2O fluids in the sediment column, and NaCl content at each depth was calculated. The results showed that NaCl content monotonically increases with depth, and the variations are similar to the trend of measured data. However, the data were not necessarily completely reproduced by the model, and deviated in some parts from the calculated profile. Such deviation may indicate fluxing of external fluid occurring in these parts, as the constant chemogravitational potential is vulnerable to an advective flow. Therefore, it is proposed that the constant chemogravitational potential condition is a possible endmember theory, influencing natural salinity variations in a static environment.
Equatorial Submesoscale Eddies Contribute to the Asymmetry in ENSO Amplitude
Authors: Wang Chengcheng , Wang Shengpeng , Jing Zhao , Geng Tao , Wang Hong , Wu Lixin 
Published: February 2023

AbstractEl Niño/Southern Oscillation (ENSO) exhibits evident amplitude asymmetry with stronger El Niño than La Niña events. Equatorial submesoscale eddies act as an important damper of ENSO via their induced upward heat flux () from the subsurface to the surface ocean. Yet their effect on ENSO amplitude asymmetry remains unexplored. Using a high‐resolution global climate simulation, we found that strengthening of in the Niño3.4 region during La Niña is more evident than weakening of during El Niño, resulting in stronger damping of La Niña than El Niño events. This asymmetric response of to ENSO is primarily ascribed to that of the temperature fronts associated with larger‐scale processes. Using a recharge oscillator model modified to include the effects of , we show that the asymmetric damping of ENSO by contributes importantly to the ENSO amplitude asymmetry.
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Authors: Casado Pedro , Rio-Machin Ana , Miettinen Juho J. , Bewicke-Copley Findlay , Rouault-Pierre Kevin , Krizsan Szilvia , Parsons Alun , Rajeeve Vinothini , Miraki-Moud Farideh , Taussig David C. , Bödör Csaba , Gribben John , Heckman Caroline , Fitzgibbon Jude , Cutillas Pedro R. 
Published: February 2023

AbstractAcute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landscape of poor prognosis AML we profiled 74 patients from two different centres (in UK and Finland) at the proteomic, phosphoproteomic and drug response phenotypic levels. These data were complemented with transcriptomics analysis for 39 cases. Data integration highlighted a phosphoproteomics signature that define two biologically distinct groups of KMT2A rearranged leukaemia, which we term MLLGA and MLLGB. MLLGA presented increased DOT1L phosphorylation, HOXA gene expression, CDK1 activity and phosphorylation of proteins involved in RNA metabolism, replication and DNA damage when compared to MLLGB and no KMT2A rearranged samples. MLLGA was particularly sensitive to 15 compounds including genotoxic drugs and inhibitors of mitotic kinases and inosine-5-monosphosphate dehydrogenase (IMPDH) relative to other cases. Intermediate-risk KMT2A-MLLT3 cases were mainly represented in a third group closer to MLLGA than to MLLGB. The expression of IMPDH2 and multiple nucleolar proteins was higher in MLLGA and correlated with the response to IMPDH inhibition in KMT2A rearranged leukaemia, suggesting a role of the nucleolar activity in sensitivity to treatment. In summary, our multilayer molecular profiling of AML with poor prognosis and KMT2A-MLLT3 karyotypes identified a phosphoproteomics signature that defines two biologically and phenotypically distinct groups of KMT2A rearranged leukaemia. These data provide a rationale for the potential development of specific therapies for AML patients characterised by the MLLGA phosphoproteomics signature identified in this study.
Mining chicken ileal microbiota for immunomodulatory microorganisms
Authors: Liu Yan , Feng Yuqing , Yang Xinyue , Lv Zhengtian , Li Peng , Zhang Meihong , Wei Fuxiao , Jin Xiaolu , Hu Yongfei , Guo Yuming , Liu Dan 
Published: February 2023

Abstract
The gut microbiota makes important contributions to host immune system development and resistance to pathogen infections, especially during early life. However, studies addressing the immunomodulatory functions of gut microbial individuals or populations are limited. In this study, we explore the systemic impact of the ileal microbiota on immune cell development and function of chickens and identify the members of the microbiota involved in immune system modulation. We initially used a time-series design with six time points to prove that ileal microbiota at different succession stages is intimately connected to immune cell maturation. Antibiotics perturbed the microbiota succession and negatively affected immune development, whereas early exposure to the ileal commensal microbiota from more mature birds promoted immune cell development and facilitated pathogen elimination after Salmonella Typhimurium infection, illustrating that early colonization of gut microbiota is an important driver of immune development. Five bacterial strains, Blautia coccoides, Bacteroides xylanisolvens, Fournierella sp002159185, Romboutsia lituseburensis, and Megamonas funiformis, which are closely related to the immune system development of broiler chickens, were then screened out and validated for their immunomodulatory properties. Our results provide insight into poultry immune system–microbiota interactions and also establish a foundation for targeted immunological interventions aiming to combat infectious diseases and promote poultry health and production.
Current situation of telemedicine research for cardiovascular risk in Japan
Authors: Shibata Shigeru , Hoshide Satoshi 
Published: February 2023

AbstractHypertension continues to be a principal risk factor for the occurrence of cardiovascular disorders, stroke, and kidney diseases. Although more than 40 million subjects suffer from hypertension in Japan, its optimal control is achieved only a subpopulation of patients, highlighting the need for novel approaches to manage this disorder. Toward the better control of blood pressure, the Japanese Society of Hypertension has developed the Future Plan, in which the application of the state-of-art information and communication technology, including web-based resources, artificial intelligence, and big data analysis, is considered as one of the promising solutions. In fact, the rapid advance of digital health technologies, as well as ongoing coronavirus disease 2019 pandemic, has triggered the structural changes in the healthcare system globally, increasing demand for the remote delivery of the medical services. Nonetheless, it is not entirely clear what evidence exists that support the widespread use of telemedicine in Japan. Here, we summarize the current status of telemedicine research, particularly in the field of hypertension and other cardiovascular risk factors. We note that there have been very few interventional studies in Japan that clearly showed the superiority or noninferiority of telemedicine over standard care, and that the methods of online consultation considerably varied among studies. Clearly, more evidence is necessary for wide implementation of telemedicine in hypertensive patients in Japan, and also those with other cardiovascular risk factors.
Delay modulates the immune response to nerve repair
Authors: Golshadi Masoud , Claffey Elaine F. , Grenier Jennifer K. , Miller Andrew , Willand Michael , Edwards Michael G. , Moore Tim P. , Sledziona Michael , Gordon Tessa , Borschel Gregory H. , Cheetham Jonathan 
Published: February 2023

AbstractEffective regeneration after peripheral nerve injury requires macrophage recruitment. We investigated the activation of remodeling pathways within the macrophage population when repair is delayed and identified alteration of key upstream regulators of the inflammatory response. We then targeted one of these regulators, using exogenous IL10 to manipulate the response to injury at the repair site. We demonstrate that this approach alters macrophage polarization, promotes macrophage recruitment, axon extension, neuromuscular junction formation, and increases the number of regenerating motor units reaching their target. We also demonstrate that this approach can rescue the effects of delayed nerve graft.
Janus-type emission from a cyclometalated iron(iii) complex
Authors: Steube Jakob , Kruse Ayla , Bokareva Olga S. , Reuter Thomas , Demeshko Serhiy , Schoch Roland , Argüello Cordero Miguel A. , Krishna Athul , Hohloch Stephan , Meyer Franc , Heinze Katja , Kühn Oliver , Lochbrunner Stefan , Bauer Matthias 
Published: February 2023

AbstractAlthough iron is a dream candidate to substitute noble metals in photoactive complexes, realization of emissive and photoactive iron compounds is demanding due to the fast deactivation of their charge-transfer states. Emissive iron compounds are scarce and dual emission has not been observed before. Here we report the FeIII complex [Fe(ImP)2][PF6] (HImP = 1,1′-(1,3-phenylene)bis(3-methyl-1-imidazol-2-ylidene)), showing a Janus-type dual emission from ligand-to-metal charge transfer (LMCT)- and metal-to-ligand charge transfer (MLCT)-dominated states. This behaviour is achieved by a ligand design that combines four N-heterocyclic carbenes with two cyclometalating aryl units. The low-lying π* levels of the cyclometalating units lead to energetically accessible MLCT states that cannot evolve into LMCT states. With a lifetime of 4.6 ns, the strongly reducing and oxidizing MLCT-dominated state can initiate electron transfer reactions, which could constitute a basis for future applications of iron in photoredox catalysis.
Ecological traits interact with landscape context to determine bees’ pesticide risk
Authors: Knapp Jessica L. , Nicholson Charlie C. , Jonsson Ove , de Miranda Joachim R. , Rundlöf Maj 
Published: February 2023

AbstractWidespread contamination of ecosystems with pesticides threatens non-target organisms. However, the extent to which life-history traits affect pesticide exposure and resulting risk in different landscape contexts remains poorly understood. We address this for bees across an agricultural land-use gradient based on pesticide assays of pollen and nectar collected by Apis mellifera, Bombus terrestris and Osmia bicornis, representing extensive, intermediate and limited foraging traits. We found that extensive foragers (A. mellifera) experienced the highest pesticide risk—additive toxicity-weighted concentrations. However, only intermediate (B. terrestris) and limited foragers (O. bicornis) responded to landscape context—experiencing lower pesticide risk with less agricultural land. Pesticide risk correlated among bee species and between food sources and was greatest in A. mellifera-collected pollen—useful information for future postapproval pesticide monitoring. We provide foraging trait- and landscape-dependent information on the occurrence, concentration and identity of pesticides that bees encounter to estimate pesticide risk, which is necessary for more realistic risk assessment and essential information for tracking policy goals to reduce pesticide risk.