bluuebunny/crossref_metadata_2025_split huggingface dataset:
FIVE-YEAR SURVIVAL OF VANCOUVER B FRACTURES AROUND A CEMENTED POLISHED TAPERED STEM TREATED WITH FIXATION
Authors: Powell-Bowns M.F.R. , Oag E. , Martin D. , Moran M. , Scott C.E.H. 
Published: March 2023

The aim of the study was to report the survival of open reduction and internal fixation (ORIF) of Vancouver B fractures associated with the Exeter Stem (ES) at a minimum of 5 years.This retrospective cohort study assessed 129 consecutive patients with Vancouver B type fractures treated with ORIF from 2008-2016 at a minimum of 5 years. Patient records were examined, and the following recorded: details of primary prosthesis, details of injury, Vancouver classification, details of operative management, complications, and requirement for reoperation. Data was analysed using SPSS. Survival analysis was undertaken using the endpoint ‘reoperation for any reason’.Mean age at fracture was 78.2 (SD10.6, 46-96) and 54 (43%) were female. Vancouver subclassifications were: 24% B1, 70.5% B2 and 5.5% B3. For all Vancouver B fractures, Kaplan Meier analysis demonstrated a 5 year survival free from reoperation of 88.8% (82.0-94.7 95%CI). Fourteen patients required reoperation, most commonly within the first year for non-union and plate fracture (5.4%). Five-year survival for any reoperation differed significantly according to fracture type (p=0.016) and was worst in B1s: B1 76.6% (61.3-91.9); B2 92.6% 986.9-98.3); and 100% of B3. Univariate analysis identified B1 type (p=0.008) and a transverse fracture pattern (p=0.003) to be significantly associated with the need for reoperation.Adopting a strategy of fixation of all Vancouver B fractures involving the ES where the fracture was anatomically reducible and the bone cement interface was well-fixed was associated with a 5 year survival, free from reoperation of 88.8%.
ASSESSING PREOPERATIVE LOWER LIMB CORONAL ALIGNMENT IN THE SETTING OF KNEE ARTHROPLASTY: A COMPARISON OF WEIGHTBEARING HIP-KNEE-ANKLE RADIOGRAPHS WITH INTRAOPERATIVE ASSESSMENT USING CT-BASED NAVIGATION
Authors: Vidakovic H. , Ohly N. 
Published: March 2023

Accurate evaluation of lower limb coronal alignment is essential for effective pre-operative planning of knee arthroplasty. Weightbearing hip-knee-ankle (HKA) radiographs are considered the gold standard. Mako SmartRobotics uses CT-based navigation to provide intra-operative data on lower limb coronal alignment during robotic assisted knee arthroplasty. This study aimed to compare the correlation between the two methods in assessing coronal plane alignment.Patients undergoing Mako partial (PKA) or total knee arthroplasty (TKA) were identified from our hospital database. The hospital PACS system was used to measure pre-operative coronal plane alignment on HKA radiographs. This data was correlated to the intraoperative deformity assessment during Mako PKA and TKA surgery.443 consecutive Mako knee arthroplasties were performed between November 2019 and December 2021. Weightbearing HKA radiographs were done in 56% of cases. Data for intraoperative coronal plane alignment was available for 414 patients. 378 knees were aligned in varus, and 36 in valgus. Mean varus deformity was 7.46° (SD 3.89) on HKA vs 7.13° (SD 3.56) on Mako intraoperative assessment, with a moderate correlation (R= 0.50, p<0.0001). Intraoperative varus deformity of 0-4° correlated to HKA measured varus (within 3°) in 60% of cases, compared to 28% for 5-9°, 17% for 10-14°, and in no cases with >15° deformity. Mean valgus deformity was 6.44° (SD 4.68) on HKA vs 4.75° (SD 3.79) for Mako, with poor correlation (R=0.18, p=0.38).In this series, the correlation between weightbearing HKA radiographs and intraoperative alignment assessment using Mako SmartRobotics appears to be poor, with greater deformities having poorer correlation.
Association of severe mental illness and septic shock case fatality rate in patients admitted to the intensive care unit: A national population-based cohort study
Authors: Lakbar Ines , Leone Marc , Pauly Vanessa , Orleans Veronica , Srougbo Kossi Josue , Diao Sambou , Llorca Pierre-Michel , Solmi Marco , Correll Christoph U. , Fernandes Sara , Vincent Jean-Louis , Boyer Laurent , Fond Guillaume 
Published: March 2023

Background
Patients with severe mental illness (SMI) (i.e., schizophrenia, bipolar disorder, or major depressive disorder) have been reported to have excess mortality rates from infection compared to patients without SMI, but whether SMI is associated with higher or lower case fatality rates (CFRs) among infected patients remains unclear. The primary objective was to compare the 90-day CFR in septic shock patients with and without SMI admitted to the intensive care unit (ICU), after adjusting for social disadvantage and physical health comorbidity.

Methods and findings
We conducted a nationwide, population-based cohort study of all adult patients with septic shock admitted to the ICU in France between January 1, 2014, and December 31, 2018, using the French national hospital database. We matched (within hospitals) in a ratio of 1:up to 4 patients with and without SMI (matched-controls) for age (5 years range), sex, degree of social deprivation, and year of hospitalization. Cox regression models were conducted with adjustment for smoking, alcohol and other substance addiction, overweight or obesity, Charlson comorbidity index, presence of trauma, surgical intervention, Simplified Acute Physiology Score II score, organ failures, source of hospital admission (home, transfer from other hospital ward), and the length of time between hospital admission and ICU admission. The primary outcome was 90-day CFR. Secondary outcomes were 30- and 365-day CFRs, and clinical profiles of patients.
A total of 187,587 adult patients with septic shock admitted to the ICU were identified, including 3,812 with schizophrenia, 2,258 with bipolar disorder, and 5,246 with major depressive disorder. Compared to matched controls, the 90-day CFR was significantly lower in patients with schizophrenia (1,052/3,269 = 32.2% versus 5,000/10,894 = 45.5%; adjusted hazard ratio (aHR) = 0.70, 95% confidence interval (CI) 0.65,0.75, p < 0.001), bipolar disorder (632/1,923 = 32.9% versus 2,854/6,303 = 45.3%; aHR = 0.70, 95% CI = 0.63,0.76, p < 0.001), and major depressive disorder (1,834/4,432 = 41.4% versus 6,798/14,452 = 47.1%; aHR = 0.85, 95% CI = 0.81,0.90, p < 0.001). Study limitations include inability to capture deaths occurring outside hospital, lack of data on processes of care, and problems associated with missing data and miscoding in medico-administrative databases.

Conclusions
Our findings suggest that, after adjusting for social disadvantage and physical health comorbidity, there are improved septic shock outcome in patients with SMI compared to patients without. This finding may be the result of different immunological profiles and exposures to psychotropic medications, which should be further explored.
Evaluation of international guidance for the community treatment of ‘personality disorders’: A systematic review
Authors: Zhan Yuen Wong Nicholas , Barnett Phoebe , Sheridan Rains Luke , Johnson Sonia , Billings Jo 
Published: March 2023

Background
Guidelines for the treatment and management of ‘personality disorders’ have been introduced to provide guidance on best practice based on evidence and views of key stakeholders. However, guidance varies and there is yet to be an overall, internationally recognised consensus on the best mental health care for people with ‘personality disorders’.

Aims
We aimed to identify and synthesise recommendations made by different mental health organisations from across the world on community treatment for people with ‘personality disorders’.

Methods
This systematic review consisted of three stages: 1. systematic literature and guideline search, 2. quality appraisal, and 3. data synthesis. We combined a search strategy involving both systematic searching of bibliographic databases and supplementary search methods of grey literature. Key informants were also contacted to further identify relevant guidelines. Codebook thematic analysis was then conducted. The quality of all included guidelines was assessed and considered alongside results.

Results
After synthesising 29 guidelines from 11 countries and 1 international organisation, we identified four main domains, with a total of 27 themes. Important key principles on which there was consensus included continuity of care, equity of access, accessibility of services, availability of specialist care, taking a whole systems approach, trauma informed approaches, and collaborative care planning and decision making.

Conclusions
Existing international guidelines shared consensus on a set of principles for the community treatment of ‘personality disorders’. However, half of the guidelines were of lower methodological quality, with many recommendations not backed by evidence.
Leaving no one behind in health: Financial hardship to access health care in Ethiopia
Authors: Tsega Yawkal , Tsega Gebeyehu , Taddesse Getasew , Getaneh Gebremariam 
Published: March 2023

Background
Financial hardship (of health care) is a global and a national priority area. All people should be protected from financial hardship to ensure inclusive better health outcome. However, financial hardship of healthcare has not been well studied in Ethiopia in general and in Debre Tabor town in particular. Therefore, this study aimed to assess the incidence of financial hardship of healthcare and associated factors among households in Debre Tabor town.

Methods
Community based cross sectional study was conducted, from May 24/2022 to June 17/2022, on 423 (selected through simple random sampling) households. Financial hardship was measured through catastrophic (using 10% threshold level) and impoverishing (using $1.90 poverty line) health expenditures. Patient perspective bottom up and prevalence based costing approach were used. Indirect cost was estimated through human capital approach. Bi-variable and multiple logistic regressions were used.

Results
The response rate was 95%. The mean household annual healthcare expenditure was Ethiopian birr 12050.64 ($227.37). About 37.1% (95%CI: 32, 42%) of the households spend catastrophic health expenditure with a 10% threshold level and 10.4% of households were impoverished with $1.90 per day poverty line. Being old, with age above 60, (AOR: 4.21, CI: 1.23, 14.45), being non-insured (AOR: 2.19, CI: 1.04, 4.62), chronically ill (AOR: 7.20, CI: 3.64, 14.26), seeking traditional healthcare (AOR: 2.63, CI: 1.37. 5.05) and being socially unsupported (AOR: 2.77, CI: 1.25, 6.17) were statistically significant factors for catastrophic health expenditure.

Conclusion
The study showed that significant number of households was not yet protected from financial hardship of healthcare. The financial hardship of health care is stronger among the less privileged populations: non-insured, the chronically diseased, the elder and socially unsupported. Therefore, financial risk protection strategies should be strengthened by the concerned bodies.
THE FORMATION OF THE INTERNAL MECHANISM OF THE SUSTAINABLE DEVELOPMENT OF THE ENTERPRISES BASED ON THE IMPLEMENTATION OF THE ORGANIZATIONAL-ECONOMIC MEASURES (ON THE MATERIALS OF THE COMPANY "ELSIB")
Authors: Bezmelnitsyn D.A. , Titov V.V. 
Published: March 2023

The paper presents methodological approaches to the formation of development strategy and scientific and practical results obtained in the Research and production Association “ELSIB” PAO for the period 2000-2022. The
Aim of the research is to analyze the results and factors to achieve the strategic goals of the enterprise in terms of reducing the effective demand for its products for these years.
The analysis showed that in difficult economic conditions it is important to build an effective management system that includes certain decision-making mechanisms. Thus, the company should maintain and strengthen the reputation of a reliable partner. The growth of production efficiency and cost optimization allows to increase the competitiveness of the enterprise. Personal work with strategic customers creates long-term relationships. After solving organizational issues in the first place goes to work with the markets. The greatest effect is achieved when implementing the cluster model. Increasing the levels of specialization and deversification leads to an increase in the efficiency of the cluster. The presence of strategic partners allows to provide access to the market segment of packaged supplies.
The development of new product markets requires constant research and development. Innovative technologies and equipment can improve production efficiency. Access to financial resources allows the company to develop and maintain competitive advantages. The main part of the investment should be the company's own funds. The system of coordination of strategic and tactical plans with operational management of production on the basis of network planning and optimization modeling is developed.
The result of the work on the creation of an effective enterprise management system was more than a twofold increase in Contracting in 2022 compared to the volume of orders in 2018.
Pyroptosis-based risk score predicts prognosis and drug sensitivity in lung adenocarcinoma
Authors: Jiang Zhengsong , Wang Xiang , Huang Jinghan , Li Guoyin , Li Shangfu 
Published: March 2023

Abstract
Pyroptosis is a recently identified form of programmed cell death; however, its role in lung adenocarcinoma (LUAD) remains unclear. Therefore, we set out to explore the prognostic potential of pyroptosis-related genes in LUAD. The pyroptosis-related risk score (PRRS) was developed by least absolute shrinkage and selection operator Cox regression and multivariate Cox regression. We found that PRRS was an independent prognostic factor for LUAD. LUAD patients in the high-PRRS group showed a significantly shorter overall survival (OS) and enriched in cell proliferation-related pathways. Then pathway enrichment analyses, mutation profile, tumor microenvironment, and drug sensitivity analysis were further studied in PRRS stratified LUAD patients. Tumor purity (TP) analyses revealed that L-PRRS LUAD patients had a lower TP, and patients in L-TP + L-PRRS subgroup had the most prolonged OS. Mutation analyses suggested that the L-PRRS LUAD patients had a lower tumor mutation burden (TMB), and patients in H-TMB + L-PRRS subgroup had the most prolonged OS. Drug sensitivity analyses showed that PRRS was significantly negatively correlated with the sensitivity of cisplatin, besarotene, etc., while it was significantly positively correlated with the sensitivity of kin001-135. Eventually, a nomogram was constructed based on PRRS and clinical characters of LUAD. Overall, the pyroptosis-related signature is helpful for prognostic prediction and in guiding treatment for LUAD patients.
Crystal structure of (E)-7-fluoro-2-(4-morpholinobenzylidene)-3,4-dihydronaphthalen-1(2H)-one, C21H20FNO2
Authors: Luo Han-Lin , Li Wen-Xuan , Bai Xian-Yong , Meng Qing-Guo , Hou Yun 
Published: March 2023

Abstract

C
21

H
20

F
N

O
2

${\mathrm{C}}_{21}{\mathrm{H}}_{20}\mathrm{F}\mathrm{N}{\mathrm{O}}_{2}$

, triclinic, P1̄ (no. 2), a = 9.2201(7) Å, b = 9.3195(8) Å, c = 11.4012(9) Å, α =

103.880

(
7
)

°

$103.880(7){}^{\circ}$

, β =

100.987

(
7
)

°

$100.987(7){}^{\circ}$

, γ =

115.090

(
7
)

°

$115.090(7){}^{\circ}$

, V = 1796.31(20)

Å
3

${\mathrm{\mathring{\text{A}}}}^{3}$

, Z = 2,

R

g
t

${R}_{gt}$

(F) = 0.0421,

w

R

r
e
f

$w{R}_{ref}$

(

F
2

${\mathrm{F}}^{2}$

) = 0.1136, T = 293 K.
Potato thermoplastic starch nanocomposite films reinforced with nanocellulose
Authors: Sharip Nur Sharmila , Tengku Yasim-Anuar Tengku Arisyah , Ujang Farhana Aziz , Faiz Norrrahim Mohd Nor 
Published: March 2023

Abstract
Potato is a widely available feedstock with biocompatibility and biodegradability properties, making it a strong candidate for producing thermoplastic starch. The application of thermoplastic starch to replace petroleum-based plastic as a sustainable and environmentally friendly approach led to its further improvement through various techniques such as modification and filler reinforcement. Numerous studies have been done addressing the properties enhancement of potato thermoplastic starch through filler reinforcement including nanocellulose. This review focus on the recent and future potential of potato-based starch as one of the feedstocks for producing potato thermoplastic starch composites reinforced with nanocellulose.
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization
Authors: Niaudet Colin , Jung Bongnam , Kuo Andrew , Swendeman Steven , Bull Edward , Seno Takahiro , Crocker Reed , Fu Zhongjie , Smith Lois E H , Hla Timothy 
Published: March 2023

AbstractSphingosine‐1‐phosphate (S1P), the circulating HDL‐bound lipid mediator that acts via S1P receptors (S1PR), is required for normal vascular development. The role of this signaling axis in vascular retinopathies is unclear. Here, we show in a mouse model of oxygen‐induced retinopathy (OIR) that endothelial overexpression of S1pr1 suppresses while endothelial knockout of S1pr1 worsens neovascular tuft formation. Furthermore, neovascular tufts are increased in Apom−/− mice which lack HDL‐bound S1P while they are suppressed in ApomTG mice which have more circulating HDL‐S1P. These results suggest that circulating HDL‐S1P activation of endothelial S1PR1 suppresses neovascular pathology in OIR. Additionally, systemic administration of ApoM‐Fc‐bound S1P or a small‐molecule Gi‐biased S1PR1 agonist suppressed neovascular tuft formation. Circulating HDL‐S1P activation of endothelial S1PR1 may be a key protective mechanism to guard against neovascular retinopathies that occur not only in premature infants but also in diabetic patients and aging people.
El sustrato y arreglo espacial de siembra en la productividad de minijardines clonales de Tectona grandis Linn. F
Authors: Rodríguez-Solís Arantxa , Badilla-Valverde Yorleny , Murillo Olman 
Published: March 2023

Introducción. Tectona grandis es la especie con la mayor área plantada en Costa Rica, por los altos precios en el mercado internacional. La producción de plantas para reforestación se ha tecnificado en el país, se desarrolla basado en tecnologías de ambientes protegidos, que permiten aumentar la productividad, disminuir costos de operación y ofrecer material de siembra durante todo el año. Objetivo. Evaluar el efecto de dos sustratos y cinco densidades de siembra en la productividad de minijardines clonales de Tectona grandis dentro de un ambiente protegido. Materiales y métodos. Se caracterizaron mediante análisis de granulometría y retención de humedad, cuatro sustratos inertes de fácil adquisición, de ellos se seleccionó el polvo de piedra como óptimo. Se estableció un ensayo experimental con diseño factorial 2x5 en San Carlos, Costa Rica, para evaluar dos sustratos (polvo de piedra solo y con 25 % de carbón) y cinco densidades de siembra (cm) de 10x10, 10x5, 7x5, 10x10 con dos plantas por hoyo y 10x10 con una planta en el medio. Cada densidad tuvo cuatro clones como efecto repetición. El ensayo se evaluó durante cinco ciclos continuos de producción de enero a setiembre del 2021. Resultados. El uso del polvo de piedra sin carbón como sustrato, registró la mayor productividad a un menor costo. El arreglo espacial de siembra de 10x10 cm con una planta en el centro (n=145 plantas/m2), registró la mayor producción de brotes por planta madre (1,16). El arreglo 7x5 cm aumentó la productividad hasta en 206 brotes m2/mes. Conclusión. El cambio de densidad de siembra del minijardín clonal, en una primera etapa a 10x10 cm con una planta en el centro, resultó en alto impacto en productividad (74 %), mayor eficiencia en el uso del espacio y mejor gradualidad del cambio en el sistema operativo.
Analysis of CO2-based trans-critical power cycle in waste heat recovery
Authors: Atik Mohammad Atikur Rahman , Imre Attila R. 
Published: March 2023

AbstractCarbon-dioxide-based trans-critical power cycle is a novel technology for waste heat recovery. This technology can handle the high-temperature exhaust gas and can be built in a compact size, which is an important feature for the auxiliary equipment for an internal combustion engine. To obtain the best output, four configurations were constructed: the basic system; one with preheater, another with regenerator and a fourth with preheater and regenerator. Special features of supercritical CO2 make these cycles able to recover more energy than the traditional organic Rankine cycle. According to this study, heat regeneration increases thermal efficiency while preheating influences the net power output. Thus, it is beneficial to add both regenerator and preheater to the basic cycle.
Occurrence of Holotrichous Ciliated Protozoa Inhabiting the Rumen of Domestic Goat Capra Hircus (L.) Families Isotrichidae (Trichostomatida) and Buetschliidae (Prostomatida)
Authors: Sanghai Prashant K. 
Published: March 2023

Rumen fluid samples of domestic goats (Capra hircus L.) were collected from slaughter houses of Kannad (Aurangabad M.S.) for the study of holotrichous ciliate protozoa. As a result of the survey of 169 rumen fluid samples the 3 species of ciliates (Isotricha intestinalis, I. prostoma and Dasytricha ruminantum) from two genera, Family Isotrichidae and one species from the genus Buetschlia (Buetschlia parva) Family Buetschliidae were studied. All these recognized ciliates were morphologically described and compared with their original descriptions and previous reports. The similarities and differences were discussed. The paper reveals that Isotricha intestinalis and Buetschlia parva are the first report in India from the rumen of goat.
The Correlation between Binaural Interaction Component of the Auditory Brainstem Response and Total Score of the Persian Version of the Spatial Hearing Questionnaire
Authors: Hazavei Seyede Mohadeseh , Rouhbakhsh Nematollah , Heidari Atta , Jalaie Shohreh 
Published: March 2023

Background and Aim: People with spatial hearing impairment have difficulty perception of speech in the presence of noise, sound localization, and estimating the distance from the sound source. In this study, the comparison between amplitude and latency of the Binaural Interaction Component of the Auditory Brainstem Response (ABR-BIC) with the total score of the Persian version of the Spatial Hearing Questionnaire (SHQ) in adults with normal hearing and moderate sensorineural hearing loss (SNHL) was evaluated.
Methods: In this cross-sectional comparative study 55, 18–45-year-old individuals including 35 of normal hearing and 20 moderate SNHL participated. All participants underwent the assessments of medical history, otoscopy, conventional audiometry, tympanometry, SHQ questionnaire, and auditory brainstem response (ABR).
Results: There was no significant correlation between the amplitude and latency of the ABR- BIC and the Persian version of the SHQ in normal groups (r=–0.085, r=0.116) and in moderate SNHL groups (r=0.030, r=0.119). The mean value of ABR-BIC range of people with normal hearing and SNHL is statistically significant (p=0.001).
Conclusion: The results showed that the amplitude and latency of ABR-BIC were not correlated with the Persian version of the SHQ in people with normal hearing and with moderate SNHL but statistically significant between the mean amplitude and latency of ABR- BIC in people with normal hearing and people with hearing loss.
Keywords: Auditory brainstem response; spatial hearing questionnaire; binaural interaction component; spatial hearing; spatial hearing disorder