bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projected Savings for Generic Oncology Drugs Purchased via Mark Cuban Cost Plus Drug Company Versus in Medicare
Authors: Cortese Brian D. , Dusetzina Stacie B. , Luckenbaugh Amy N. , Al Hussein Al Awamlh Bashir , Stimson C.J. , Barocas Daniel A. , Penson David F. , Chang Sam S. , Talwar Ruchika 
Published: June 2023

PURPOSE Self-administered oncology drugs contribute disproportionately to Medicare Part D spending; prices often remain high even after generic entry. Outlets for low-cost drugs such as Mark Cuban Cost Plus Drug Company (MCCPDC) offer opportunities for decreased Medicare, Part D, and beneficiary spending. We estimate potential savings if Part D plans obtained prices such as those offered under the MCCPDC for seven generic oncology drugs. METHODS Using the 2020 Medicare Part D Spending dashboard, Q3-2022 Part D formulary prices, and Q3-2022 MCCPDC prices for seven self-administered generic oncology drugs, we estimated Medicare savings by replacing Q3-2022 Part D unit costs with costs under the MCCPDC plan. RESULTS We estimate potential savings of $661.8 million (M) US dollars (USD; 78.8%) for the seven oncology drugs studied. Total savings ranged from $228.1M USD (56.1%) to $2,154.5M USD (92.4%) compared with 25th and 75th percentiles of Part D plan unit prices. The median savings replacing Part D plan prices were abiraterone $338.0M USD, anastrozole $1.2M USD, imatinib 100 mg $15.6M USD, imatinib 400 mg $212.0M USD, letrozole $1.9M USD, methotrexate $26.7M USD, raloxifene $63.8M USD, and tamoxifen $2.6M USD. All 30-day prescription drug prices offered by MCCPDC generated cost savings except for three drugs offered at the 25th percentile Part D formulary pricing: anastrozole, letrozole, and tamoxifen. CONCLUSION Replacing current Part D median formulary prices with MCCPDC pricing could yield significant savings for seven generic oncology drugs. Individual beneficiaries could save nearly $25,200 USD per year for abiraterone or between $17,500 USD and $20,500 USD for imatinib. Notably, Part D cash-pay prices for abiraterone and imatinib under the catastrophic phase of coverage were still more expensive than baseline MCCPDC prices.
Differentiated Thyroid Cancers in Young Adults Versus Children: Clinical Characteristics and 10-year Follow-up Outcomes
Authors: Satapathy Swayamjeet , Majeed Althaf K , Ballal Sanjana , Bal Chandrasekhar 
Published: June 2023

Abstract

Background
Differentiated thyroid cancer (DTC) in young adults has been steadily rising in incidence over the decades. However, data on long-term outcomes in this specific cohort remain limited. In this study, we intended to evaluate young adults with DTC with regard to their clinical characteristics and treatment outcomes and compare the same vis-à-vis pediatric patients with DTC.

Methods
Data of pediatric (≤18 years) and young adult (19-39 years) patients with DTC, from 1971 to 2016, were sequentially extracted and analyzed for clinical characteristics, treatment responses, rates of recurrent/persistent disease, and disease-free survival (DFS).

Results
A total of 1803 patients with DTC were included (pediatric cohort: n = 176; young adult cohort: n = 1627). Pediatric patients with DTC had more frequent adverse baseline features including extrathyroidal extension (P = .040), nodal and distant metastases, and American Thyroid Association high-risk disease (P &lt; .001 each). At 2 years posttreatment, young adult patients with DTC had significantly lower incomplete responses compared with pediatric patients with DTC (223/1627; 13.7% vs 94/176, 53.4%, respectively; P &lt; .001). Over a median follow-up of 10.7 years, 120/1627 (7.4%) young adult patients with DTC had recurrent/persistent disease vs 23/176 (13.1%) pediatric patients with DTC (P = .012). The 10-year DFS probability was 93.6% for the young adult patients with DTC vs 88.7% for the pediatric patients with DTC (P = .007). American Thyroid Association high-risk disease and incomplete response at 2 years were independent predictors of significantly worse DFS in the young adult cohort (P &lt; .001 each).

Conclusions
Young adult DTCs behave less aggressively compared with their pediatric counterparts with excellent long-term outcomes. Appropriate initial and dynamic risk stratification can help optimize treatment decisions and follow-up strategies.
Associations of Macronutrients Intake With MRI-determined Hepatic Fat Content, Hepatic Fibroinflammation, and NAFLD
Authors: Chen Shen , Pang Juan , Huang Rong , You Yiran , Zhang Haoyang , Xue Hongliang , Chen Xu 
Published: June 2023

Abstract

Context
A healthy lifestyle is the cornerstone of management in nonalcoholic fatty liver disease (NAFLD). However, the associations between dietary macronutrient composition and different aspects of NAFLD pathology are unclear and dietary recommendations for NAFLD are lacking.

Objective
This work aimed to evaluate the associations of dietary macronutrient composition with hepatic steatosis, hepatic fibroinflammation, and NAFLD.

Methods
In this cross-sectional study, a total of 12 620 UK Biobank participants who completed both the dietary questionnaire and magnetic resonance imaging (MRI) examination were included in this study. Dietary consumption of macronutrient was self-reported and calculated. MRI-determined hepatic fat content, fibroinflammation, and NAFLD were estimated.

Results
First, we found that saturated fatty acid (SFA) intake was associated with higher hepatic steatosis, fibroinflammation, and NAFLD prevalence. In contrast, higher fiber or protein intake was reversely correlated with hepatic steatosis and fibroinflammation. Interestingly, starch or sugar intake was significantly associated with hepatic fibroinflammation, whereas monounsaturated fatty acid (MUFA) intake was negatively correlated with hepatic fibroinflammation. Isocaloric analysis revealed that replacing SFA with sugar, fiber, or protein was significantly associated with a reduction in hepatic steatosis, while replacing starch, sugar, or SFA with protein or MUFA was significantly correlated with a decrease in hepatic fibroinflammation.

Conclusion
Overall, our results demonstrate that specific macronutrients are associated with different aspects of NAFLD, and specific dietary compositions should be recommended for distinct NAFLD-risk populations.
Warm Responsive Neurons in the Hypothalamic Preoptic Area are Potent Regulators of Glucose Homeostasis in Male Mice
Authors: Deem Jennifer D , Phan Bao Anh , Ogimoto Kayoko , Cheng Alice , Bryan Caeley L , Scarlett Jarrad M , Schwartz Michael W , Morton Gregory J 
Published: June 2023

Abstract
When mammals are exposed to a warm environment, overheating is prevented by activation of “warm-responsive” neurons (WRNs) in the hypothalamic preoptic area (POA) that reduce thermogenesis while promoting heat dissipation. Heat exposure also impairs glucose tolerance, but whether this also results from activation of POA WRNs is unknown. To address this question, we sought in the current work to determine if glucose intolerance induced by heat exposure can be attributed to activation of a specific subset of WRNs that express pituitary adenylate cyclase-activating peptide (ie, POAPacap neurons). We report that when mice are exposed to an ambient temperature sufficiently warm to activate POAPacap neurons, the expected reduction of energy expenditure is associated with glucose intolerance, and that these responses are recapitulated by chemogenetic POAPacap neuron activation. Because heat-induced glucose intolerance was not blocked by chemogenetic inhibition of POAPacap neurons, we conclude that POAPacap neuron activation is sufficient, but not required, to explain the impairment of glucose tolerance elicited by heat exposure.
Interplay of Cortisol, Testosterone, and Abdominal Fat Mass in Normal-weight Women With Polycystic Ovary Syndrome
Authors: Dumesic Daniel A , Turcu Adina F , Liu Haiping , Grogan Tristan R , Abbott David H , Lu Gwyneth , Dharanipragada Devyani , Chazenbalk Gregorio D 
Published: June 2023

Abstract

Context
Ovarian and adrenal steroidogenesis underlie endocrine-metabolic dysfunction in polycystic ovary syndrome (PCOS). Adipocytes express aldo-keto reductase 1C3 and type 1 11β-hydroxysteroid dehydrogenase, which modulate peripheral androgen and cortisol production.

Objectives
To compare serum adrenal steroids, including 11-oxygenated androgens (11-oxyandrogens), cortisol, and cortisone between normal-weight women with PCOS and body mass index- and age-matched ovulatory women with normal-androgenic profiles (controls), and assess whether adrenal steroids associate with abdominal adipose deposition.

Design
Prospective, cross-sectional, cohort study.

Setting
Academic medical center.

Patients
Twenty normal-weight women with PCOS and 20 body mass index-/age-matched controls.

Intervention(s)
Blood sampling, IV glucose tolerance testing, and total-body dual-energy x-ray absorptiometry.

Main Outcome Measure(s)
Clinical characteristics, hormonal concentrations, and body fat distribution.

Results
Women with PCOS had higher serum total/free testosterone (T) and androstenedione (A4) levels and a greater android/gynoid fat mass than controls (androgens P &lt; .001; android/gynoid fat mass ratio, P = .026). Serum total/free T and A4 levels correlated positively with android/gynoid fat mass ratio in all women combined (P &lt; .025, all values). Serum 11ß-hydroxyA4, 11-ketoA4, 11ß-hydroxyT, 11-ketoT, cortisol, and cortisone levels were comparable between female types and unrelated to body fat distribution. Serum 11-oxyandrogens correlated negatively with % total body fat, but lost significance adjusting for cortisol. Serum cortisol levels, however, correlated inversely with android fat mass (P = .021), with a trend toward reduced serum cortisol to cortisone ratio in women with PCOS vs controls (P = .075), suggesting diminished 11β-hydroxysteroid dehydrogenase activity.

Conclusion
Reduced cortisol may protect against preferential abdominal fat mass in normal-weight PCOS women with normal serum 11-oxyandrogens.
Queer Futures for an Aging Planet
Authors: Jewusiak Jacob 
Published: June 2023

Abstract
Associated with disaster metaphors such as floods, avalanches, tsunamis, and icebergs, older people have come to take the symbolic form of the environmental impacts they are imagined causing. Yet even as older people are posited as the cause and imaginatively take the shape of the disaster, they are also registered as especially vulnerable to the effects of rising temperatures and extreme weather. While the tendency toward blame and care are not logically incompatible, this tension has resulted in a cultural narrative that fuels a deep sense of unfairness across generations. This article reads the sterility dystopia—a subgenre of science fiction where a global inability to have children results in aging populations and societal collapse—as registering the anxiety that arises at the intersection of age and the environment. Taking The Children of Men as a case study, I suggest that P. D. James's novel expresses the demographic dread arising from the relative shift in younger and older populations—not of a world lacking children, as we might expect, but of one catastrophized by the overabundance of the old and aging. Pushing against the link between climate activism and generational futurity, I draw on queer theory to argue that intergenerational kinship in the present privileges the values of affiliation, contingency, and immediacy that can inspire a more sustainable future.
Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry
Authors: Stajković Nevena , Liu Yuanyuan , Arsić Aleksandra , Meng Ning , Lyu Hang , Zhang Nan , Grimm Dirk , Lerche Holger , Nikić-Spiegel Ivana 
Published: June 2023

ABSTRACT
The axon initial segment (AIS) is a highly specialized neuronal compartment that regulates the generation of action potentials and maintenance of neuronal polarity. Live imaging of the AIS is challenging due to the limited number of suitable labeling methods. To overcome this limitation, we established a novel approach for live labeling of the AIS using unnatural amino acids (UAAs) and click chemistry. The small size of UAAs and the possibility of introducing them virtually anywhere into target proteins make this method particularly suitable for labeling of complex and spatially restricted proteins. Using this approach, we labeled two large AIS components, the 186 kDa isoform of neurofascin (NF186; encoded by Nfasc) and the 260 kDa voltage-gated Na+ channel (NaV1.6, encoded by Scn8a) in primary neurons and performed conventional and super-resolution microscopy. We also studied the localization of epilepsy-causing NaV1.6 variants with a loss-of-function effect. Finally, to improve the efficiency of UAA incorporation, we developed adeno-associated viral (AAV) vectors for click labeling in neurons, an achievement that could be transferred to more complex systems such as organotypic slice cultures, organoids, and animal models.
The mechanistic basis and adaptive significance of cross-tolerance: a ‘pre-adaptation’ to a changing world?
Authors: Rodgers Essie M. , Gomez Isaza Daniel F. 
Published: June 2023

ABSTRACTProtective responses are pivotal in aiding organismal persistence in complex, multi-stressor environments. Multiple-stressor research has traditionally focused on the deleterious effects of exposure to concurrent stressors. However, encountering one stressor can sometimes confer heightened tolerance to a second stressor, a phenomenon termed ‘cross-protection’. Cross-protection has been documented in a wide diversity of taxa (spanning the bacteria, fungi, plant and animal kingdoms) and habitats (intertidal, freshwater, rainforests and polar zones) in response to many stressors (e.g. hypoxia, predation, desiccation, pathogens, crowding, salinity, food limitation). Remarkably, cross-protection benefits have also been shown among emerging, anthropogenic stressors, such as heatwaves and microplastics. In this Commentary, we discuss the mechanistic basis and adaptive significance of cross-protection, and put forth the idea that cross-protection will act as a ‘pre-adaptation’ to a changing world. We highlight the critical role that experimental biology has played in disentangling stressor interactions and provide advice for enhancing the ecological realism of laboratory studies. Moving forward, research will benefit from a greater focus on quantifying the longevity of cross-protection responses and the costs associated with this protective response. This approach will enable us to make robust predictions of species' responses to complex environments, without making the erroneous assumption that all stress is deleterious.
Infodemic in Public health a reemerging public health threat: a scoping review
Authors: Pai Mithun , Yellapurkar Shweta , Shodhan Shetty Aishwarya 
Published: June 2023

Background: Infodemic is a neologism of ‘information’ and ‘epidemic’ coined in the year 2003. Evidence mapping is a technique to appraise the literature which enables the extent of research activity in a specific area to be discovered. The main objective of this evidence synthesis presents the outcomes of an evidence map that was directed to know the extent of Infodemics and its effects on public health. Methods: The following methods were used to construct this evidence synthesis: Phase I. Construct a Broad Question Referring to the Field of Analysis. Phase II; Defining Key Variables to Be Mapped, identifying the characters of each variable and Outline Inclusion and Exclusion Criteria for the variables. Phase III: Literature search. Phase IV: Screening and Charting the Appropriate Evidence within the Synthesis. Results: Authors identified 55 records through database searching, after screening for duplicates, 53 records screened at title/abstract level of which, 16 records were removed because of lack of complete article or articles were not in English. 37 articles were eligible for full text screening, 37 full-text articles were than assessed for eligibility and only 22 articles were included as per inclusion criteria with an interrater Outcome Kappa value: 0.91. The strength of agreement was considered to be 'excellent'. Conclusions: This synthesis focused majorly on the gaps in the research focused on infodemic. The two main gaps identified were lack of systematically conducted research and poor digital health literacy. As infodemic is a new phenomenon with respect to the COVID-19 pandemic it was an eye opener at different levels of public health, furthermore this evidence map points out areas for further research on the impact of infodemic.
The effect of green mussel (Perna viridis) shells’ hydroxyapatite application on alkaline phosphatase levels in rabbit femur bone defect
Authors: Tjandra Kevin Christian , Novriansyah Robin , Limijadi Edward Kurnia Setiawan , Kuntjoro Lydia , Hendrianingtyas Meita 
Published: June 2023

Background: A non-union fracture is one of the most common complications arising from an untreated fracture. Bone grafts are able to fasten bone healing which can prevent and cure non-union fractures. Therefore, alternative hydroxyapatite bone grafts from waste resources are needed to increase the availability of bone grafts in the healthcare system. A bone substitute, hydroxyapatite (HA), has the ability to prevent non-union fractures. Green mussel shell contains 95.69 percent HA, allowing for an annual production of 133.97–287.07 tons per ha of HA, and is a potent alternative material in the manufacture of HA. Methods: This research was conducted for four months using a true experimental research method with a post-test-only control group design. This study used 36 New Zealand rabbits (Oryctolagus cuniculus) which were divided into 9 groups: positive control, negative control, and intervention at weeks 2, 4 and 6 after the intervention. All groups were subjected to three general procedures: pre-surgery, surgery, and post-surgery. Results: The findings demonstrated that green mussel shell HA has efficacy in accelerating bone healing, better than HA bovine, as compared to the 6-week negative control group and demonstrated a significant difference (p < 0.05). Conclusions: Green mussel hydroxyapatite is proven to be able to fasten and maximize the bone healing process as fast as bovine HA, and even has higher efficacy than bovine HA.
Modeling the spatio-temporal distribution of Karenia brevis blooms in the Gulf of Mexico
Authors: Guirhem Gency L. , Baker Laurie , Moraga Paula 
Published: June 2023

Background: Harmful algal blooms (HABs) of the toxic dinoflagellate Karenia brevis impact the overall ecosystem health. Methods: K. brevis cell counts were extracted from Harmful Algal BloomS Observing System (HABSOS) in situ data and matched with 0.25º resolution environmental information from the Copernicus database to generate spatio-temporal maps of HABs in the Gulf of Mexico (GoM) between 2010 and 2020. The data was used to analyze the relationship between spatial and temporal variability in the presence/absence of K. brevis blooms (≥100,000 cells/L) and biotic and abiotic variables using Generalized Additive Models (GAM). Results: The variability of blooms was strongly linked to geographic location (latitude and salinity), and temporal variables (month and year). A higher probability of K. brevis blooms presence was predicted in areas with negative sea surface height (SSH) values, silicate concentration (0, 30-35 mmol. m-3), sea surface temperature of 22-28 oC, and water currents moving south-westward (225º). The smooth effect of each environmental variable shows a bimodal pattern common in semi-enclosed basins such as GoM. The spatial predictions from the model identified an important permanent area in (1) Southwest Florida (25.8-27.4o latitude), and four seasonally important areas, (2) North Central Florida (3) Central West Florida, (4) Alabama on Gulf Shores and (5) Mississippi with higher bloom probabilities during the fall to winter season (November-January). Results also suggest that HABs can extend until ≥ 300 km offshore; starting to form in March and reaching a peak in September, and were swept to the coastal area during fall and winter. This suggests the role of upwelling and water circulation in GoM for the accumulation of cells and HABs. Information on the spatio-temporal dynamics of K. brevis blooms and understanding the environmental drivers are crucial to support more holistic spatial management to decrease K. brevis blooms incidence in bodies of water.
The Value of Personal Data in Internet Commerce: A High-Stakes Field Experiment on Data Regulation Policy
Authors: Sun Tianshu , Yuan Zhe , Li Chunxiao , Zhang Kaifu , Xu Jun 
Published: June 2023

Personal data have become a key input in internet commerce, facilitating the matching between millions of customers and merchants. Recent data regulations in China, Europe, and the United States restrict internet platforms’ ability to collect and use personal data for personalized recommendation and may fundamentally impact internet commerce. In collaboration with the largest e-commerce platform in China, we conduct a large-scale field experiment to measure the potential impact of data regulation policy and to understand the value of personal data in internet commerce. For a random subset of 555,800 customers on the Alibaba platform, we simulate the regulation by banning the use of personal data in the home page recommendation algorithm and record the matching process and outcomes between these customers and merchants. Compared with the control group with personal data, we observe a significantly higher concentration in the algorithmic recommendation of products in the treatment group and a very sharp decrease in the matching outcomes as measured by both customer engagement (click-through rate and product browsing) and market transaction (sales volume and amount). The negative effect is disproportionate and more pronounced for niche merchants and customers who would benefit more from e-commerce. We discuss the potential economic impact of data regulation on internet commerce as well as the role of personal data in generating value and fostering long-tail innovations. This paper was accepted by Chris Forman, information system. Funding: Z. Yuan wants to acknowledge financial support from NSFC [Grants 72203202, 72192803 and 72141305]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4828 .