bluuebunny/crossref_metadata_2025_split huggingface dataset:
Falta de medicamentos por parte del estado en enfermedades catastróficas y su aplicación en acción de protección constitucional
Authors: Abendaño Márquez Vanessa del Carmen , Cevallos Ortega Francisco Javier , Quizhpe Guamán Johanna Cecibel , Mena Manzanillas Paulina Leticia 
Published: May 2023

RESUMEN
Dentro del presente trabajo, se presenta una serie de conocimientos específicos sobre la legislación ecuatoriana vigente. Relacionados directamente con la acción de protección tipificada debidamente en la Constitución de la República del Ecuador del año 2008, y las diferentes necesidades que presentan los pacientes con enfermedades catastróficas para poder acceder a medicamentos específicos que no se encuentra debidamente subsidiados por el estado ecuatoriano.
Asimismo, se da a conocer en forma sencilla y técnica un concepto de enfermedades catastróficas. Las normas pertinentes y derechos vigentes (en las diferentes normas legales) de los ciudadanos ecuatorianos que sufren algún tipo de enfermedad catastrófica. Los procedimientos jurídicos (acción de protección), que suele ser una de las herramientas más utilizadas por los abogados para poder conseguir que el Estado ecuatoriano pueda garantizar Derechos Constitucionales básicos que se encuentran dentro de la Carta Magna vigente.
Finalmente, se brinda información necesaria pertinente sobre algunos medicamentos que son de difícil acceso para cubrir ciertas enfermedades catastróficas. Su uso médico es explicado en forma eficiente con la finalidad de dar a comprender la importancia de su aplicación.
La información que se presenta en el actual artículo científico guarda relación directa con la legislación ecuatoriana vigente. Su aplicación es de nivel nacional. La metodología utilizada para la recolección de dicha información nace de los textos vigentes a la presente fecha. Y las muestras y técnicas empleadas son las estadísticas a nivel nacional que son recolectadas por los organismos estatales de salud pública.
Genetic spectrum of familial and sporadic dilated cardiomyopathy: arrhythmic phenotypes associated with mutations in the lamin A/C (LMNA) gene
Authors: Vaikhanskaya T. G. , Sivitskaya L. N. , Kurushka T. V. , Liaudanski A. D. , Danilenko N. G. 
Published: May 2023

Purpose. To study the diagnostic value of cascade family screening and the spectrum of genetic variants in patients with familial and sporadic DCM, assess clinical outcomes and comparative analysis of 5-year event-free survival.Materials and methods. The study included 156 unrelated patients with verified DCM. All patients (aged 46 [34; 57] years; 125 (80%) male; LVEF 31 [24; 38]%; LV EDD 68 [61; 74] mm; follow-up period - 77 [59; 108] months) a complex of clinical and instrumental studies (ECG, ECHO, HM, MRI), cascade family screening with genetic testing (NGS+Sanger) and segregation analysis were performed.Results. Criteria for familial DCM were identified in 73 (46.8%) probands. The genetic cause of DCM was identified in 47 (64,4%) familial cases, while for sporadic form DCM pathogenic variants were detected in 19 (22,9%) patients. The dominant mutations were truncating variants in the titin gene (10,9%) and variants in the lamin A/C (LMNA) gene - 8,33%. As a result of the evaluation of cumulative event-free survival (Kaplan-Meier curves), LMNA carriers showed the poor 5-year prognosis for ventricular tachyarrhythmic events (x2=39.9; p=0,0001) and composite adverse outcomes (x2=12.1; p=0.001). Probands who had a familial DCM (log rang x2=38.5; p=0,0001) showed the worst prognosis and low cumulative survival when compared with patients of the sporadic DCM.Conclusion. Cascade clinical family screening and genetic testing in the DCM cohort increased the level of diagnosis of familial DCM from 4.5% to 46.8%. Associations of LMNA mutations with life-threatening tachyarrhythmias are defined as prognostically significant, that confirms the important role of genetic stratification of arrhythmic risk.
Systematic Study of four species of Genus Hedotettix of family Tetrigidae (Califera: Orthoptera) with three new records from Sindh, Pakistan
Authors: Sanam Saiqa , Riffat Sultana  , Surriya Sanam  
Published: May 2023

Pygmy grasshoppers are ⁓14-20 mm in length, and are recognizable by a long pronotum, that extends over the length of the abdomen. Pygmy grasshoppers usually found near water, such as ponds and steams. Occasionally found in dry habitats, woodlands, rice fields and in sandy areas with lichen. These grasshoppers especially eat roots of plants, seedlings, mosses, fungi, algae and cause considerable damage to crops. In this regard four species of the family Tetrigidae were recorded and three species, namely Hedotettix costatus Hancock, 1912, H. rusticus Bolivar, 1887, H. angustivertex (Bolivar, 1908) are recorded as new country and state records. An attempt has been made to reveal the systematics of Tetrigidae in Sindh by identification based on morphological characterization, ecological distribution, photographs, line drawings and measurements of different parameters to produce a taxonomic key to the species of Sindh.
Assessment of Selected Trace Metals in Commonly Consumed Canned and Raw Food Products in Sindh, Pakistan
Authors: Maitlo Amjad Ali , Ansari Sanaullah , Soomro Amjad Hussain , Memon Almas Fatima , Mughal Insaf Raza , Jaffar Ghulam , Ansari Sanaullah 
Published: May 2023

The current study uses a flame atomic absorption spectrometer to quantify seven trace elements—Chromium (Cr), Cobalt (Co), Zinc (Zn), Manganese (Mn), Sodium (Na), Potassium (K), and Calcium (Ca) in canned and raw food products sold in Sukkur and Khairpur, Sindh, Pakistan. Current study results were compared to WHO/FAO maximum and minimum limits. Most samples were contaminated with trace elements (likely from anthropogenic activities, local industries, and brick kilns) and exceeded the allowable limits. Food products had varied metal content. In canned food products, Cr was max in peas (6.99 mg/kg) and min in pineapple (3.08 mg/kg), Co was max in pineapple (3.11 mg/kg) and min in honey (1.50 mg/kg), Zn was max in tamarind (5.77 mg/kg) and min in pineapple and mushroom (2.95 mg/kg), Mn was max in ginger (0.39 mg/kg) and min in pineapple and mangoes (0.24 mg/kg), Na was max in ginger (167 mg/kg) and min in honey (76.7 mg/kg), and K was max in tamarind (4942 mg/kg) and min in honey (76.7 mg In raw food products, Cr was highest in carrot (6.21 mg/kg) and lowest in pineapple (3.08 mg/kg), Co was highest in pineapple (3.24 mg/kg) and lowest in carrot (1.14 mg/kg), Zn was highest in carrot (6.33 mg/kg) and lowest in pineapple and honey (2.96 mg/kg), Mn was highest in ginger (0.41 mg/kg) and lowest in honey (0.24 mg/kg), Na was highest in garlic (202 mg/kg) and lowest in strawberries (65.1 mg/kg), and K was highest in tamarind (4963 mg/kg) and lowest in butter. In conclusion, to ensure public safety, these elements must be monitored in canned and raw food products
Comparison between presepsin, procalcitonin, and CRP as biomarkers to diagnose sepsis in critically ill patients
Authors: Juneja Deven , Jain Navin , Singh Omender , Goel Amit , Arora Shweta 
Published: May 2023

Abstract

Background and Aims:
Mortality associated with sepsis continues to remain high. Early diagnosis and aggressive management may improve outcomes. Biomarkers may help in early diagnosis, but the search for an ideal biomarker continues. Presepsin has been introduced as a new biomarker, however, it still needs validation before its use becomes routine. In this study, we aimed to compare the efficacy of various biomarkers in patients with suspected sepsis.

Material and Methods:
A retrospective analysis of 100 patients with suspected infection, admitted in the medical intensive care unit (ICU) was conducted. Diagnosis of sepsis was made on the basis of the current surviving sepsis guidelines criteria.

Results:
Out of 100 patients, 70 were diagnosed to have sepsis, and overall ICU mortality was 22%. Overall, C-reactive protein (CRP) was positive in 98, procalcitonin in 75, and presepsin in 64 patients. For diagnosis of sepsis the sensitivity, specificity, and AUC, respectively, for CRP was 98.6%, 3.3%, and 0.725. For procalcitonin (>0.5 ng/ml) it was 87.1%, 53.3%, and 0.776, and for procalcitonin (>1 ng/ml) 70%, 70%, and 0.816, respectively. For presepsin sensitivity, specificity, and AUC, respectively, for diagnosis of sepsis was 77.1%, 66.7%, and 0.734. For ICU mortality, sensitivity and specificity for CRP was 95.5% and 1.3%, for procalcitonin (>0.5) 72.7% and 24.4.%, for procalcitonin (>1) 59.1% and 42.3%, and for presepsin 61.5% and 27.3%, respectively.

Conclusion:
Inflammatory markers may be raised in a large proportion of ICU patients, even in those without sepsis. Procalcitnonin and presepsin had similar efficacy in diagnosing sepsis. However, none of the three biomarkers studied were accurate in predicting ICU mortality.
Медленные сходимости эргодических средних
Authors: Ryzhikov Valerii Valentinovich 
Published: May 2023

Теорема Биркгофа утверждает, что для эргодического автоморфизма средние по времени сходятся к среднему по пространству.
Для заданной последовательности $\psi(n)\to+0$ Кренгель показал, что для любого эргодического автоморфизма существует
такой индикатор, что соответствующие временные средние сходятся п.в. со скоростью, превосходящей $\psi$. Мы даем
новые доказательства отсутствия оценок для скоростей сходимости, отвечая на один из вопросов Подвигина.
Библиография: 4 названия.
PENGARUH MODEL PEMBELAJARAN PROBLEM BASED LEARNING BERBANTUAN FLASHCARD TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS
Authors: Afwah Lutvia Nurul , Hendrastuti Zuida Ratih , Franita Yesi 
Published: May 2023

The purpose of this study is to analyze the effect of the flashcard-assisted Problem Based Learning learning model on the mathematical problem solving ability. The research design used in this study is quasi experimental design. The research method used is quantitative research. The population in this study was the entire class VIII which amounted to 120 students, then for the sample two classes were taken, namely class VIII A as an experimental class and class VIII B as a control class. The sample in this study was taken by cluster random sampling technique. Data collection techniques include interviews, observations, tests, validation, and documentation. The data analysis technique used is the analysis of the average difference in significance test between the two groups with test prerequisites, namely normality tested using the Liliefors test and homogeneity tested using the Bartlett test. Based on the results of analysis and data processing using the t-test, it was obtained that the Sig. (2-tailed) value < 0.05 which means that the rejected and with a significant level of 5%. Based on these results, it can be concluded that there is an influence of the flashcard-assisted Problem Based Learning learning model on the mathematical problem solving ability of grade VIII. This can be a reference that the flashcard-assisted Problem Based Learning model can be used as a relevant learning model to improve students' mathematical problem-solving skills
PEMILIHAN JENIS BIBIT UNGGUL TANAMAN NANAS DENGAN METODE ORESTE
Authors: Ningsih Lisa Setia , Lubis Riri Syafitri , Aprilia Rima 
Published: May 2023

Indonesia is a country that has a tropical climate that is rich in fruits. One of the tropical fruit commodities in Indonesia is pineapple. Pineapple is most interest by public because price of the fruit is cheap, easy to obtain and has a distinctive aroma, taste, and color. Pineapple can be used as a medicinal plant. In the cultivation of pineapple plants, require the availability of good land and availability of seedlings that can be obtained in a vegetative and generative methods. Pineapple seeds obtained by generative means are fruit crowns, tiller shoots, root shoots, fruit shoots, stem cuttings. Meanwhile, pineapple seeds obtained by generative means are pineapple seeds. In pineapple cultivation carried out by pineapple farmers in Panribuan Village, Simalungun Regency, it is still based on farmer’s instincts and feelings, so that pineapple harvests often occur that are less than optimal, are not resistant to pests, yields are less than optimal, harvest age becomes longer. With the alternatives that exist in the decision support system with the ORESTE method to select superior seeds of pineapple plants. A decision support system is one of the ways to organizing information intended to be used in decisions making. ORESTE is a method that was built for conditions where a set of alternatives will be sorted by criteria according to the levels of importance. From the calculation results obtained the best alternative is sapling shoots with the preference value of 1,547
Non-Intrusive Load Monitoring (NILM), Interests and Applications
Authors: TOKAM Leonce Wehnelt , OURO-DJOBO Sanoussi S. 
Published: May 2023

In developing effective energy management mechanisms, new concepts have been developed to provide new approaches. Non-intrusive load monitoring (NILM) is an approach that was originally developed to allow the occupants of a room to identify the contribution of each appliance to the total electricity consumption of the room through a single point measurement device. The aim is to provide customers with information that will enable them to act as `` ` consum'actors", i.e., people who undertake to change their electricity consumption habits for an objective cause. The progress of artificial intelligence in its various forms (machine learning, big data, internet of things) have greatly contributed to increase the interest of NILM among researchers in different fields. Indeed, some of them are adapting this concept to research areas such as water, transport, health, the environment and agriculture. In this context, applications in these fields have been developed to show the potential and benefits of using this approach. In addition to presenting non-intrusive load monitoring (NILM) in its general framework, this article presents the interests and applications of this approach in various fields.
HUBUNGAN MANAJEMEN WAKTU BELAJAR DENGAN HASIL BELAJAR PKN KELAS XI SMK SWASTA HARAPAN BANGSA TAHUN 2022
Authors: Barutu Herlina , Gultom Linda H.M , Purba Alimin , Naiborhu Murni 
Published: May 2023

Tujuan dari penelitian ini adalah untuk mengetahui hubungan yang signifikan antara manajemen waktu belajar dengan hasil belajar kewarganegaraan pada siswa SMK Swasta Harapan Bangsa tahun ini. Studi jenis ini secara deskriptif berkorelasi. Populasi penelitian ini adalah seluruh siswa kelas XI SMK Swasta Harapan Bangsa Tahun 2022 dan populasi penelitian ini adalah 30 orang dengan menggunakan sampel utuh. Instrumen yang digunakan untuk pengumpulan data adalah angket dan dokumen, manajemen waktu pembelajaran memiliki 15 item dengan 4 pilihan yang diuji validitas dan reliabilitasnya, dan hasil belajar meliputi dokumen dengan daftar nilai siswa. Hasil uji analisis normalitas data ketepatan manajemen waktu belajar kelas XI SMK Swasta Harapan Bangsa Tahun 2022 berdistribusi normal dengan perhitungan x2hitung < x2tabel (7,27 < 43,77). Hasil belajar PKn siswa Kelas XI Swasta Harapan Bangsa Tahun 2022 berdistribusi normal dengan hasil hitung x2h < x2t (17,11 < 43,77). Hasil uji linearitas pengelolaan data Manajemen Waktu belajar dengan hasil belajar PKn menggunakan rumus Y = 75,62 + 0,03 X dengan Fhitung > Ftabel (28 > 4,20). Hasil tes manajemen waktu siswa kelas XI SMK Swasta Harapan Bangsa tahun 2022 cenderung cukup (50%) dan hasil belajar PKn kelas XI SMK Swasta Harapan Bangsa tahun 2022 cenderung cukup (63,33%). Berdasarkan hasil analisis koefisien korelasi X dan Y diperoleh rhitung = 1,831 dan rtabel = 0,349 (1,831 > 0,349>. Hal ini menunjukkan bahwa ada hubungan antara manajemen waktu pembelajaran dengan hasil belajar kewarganegaraan siswa kelas XI SMK Swasta Harapan Bangsa dengan uji “t” diperoleh thitung = 4,11 dan ttabel = 1,69 (thitung > ttabel) (4,11 > 1,69), hal ini menunjukkan bahwa terdapat hubungan yang signifikan antara manajemen waktu dengan hasil belajar PKn siswa kelas XI SMK Swasta Harapan Bangsa pada tahun 2022.
HUBUNGAN PEMAHAMAN NILAI GOTONG ROYONG DENGAN SIKAP PEDULI LINGKUNGAN DI DESA SUKA KEC.TIGAPANAH KAB.KARO TAHUN 2022
Authors: Br Tarigan Liasna , Malau Lamris , Purba Alimin , Naiborhu Murni 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui hubungan signifikan antara pemahaman nilai gotong royong dengan sikap peduli lingkungan di desa suka kec. tiganah kab. karo tahun 2022.Jenis penelitian ini adalah deskriptif korelasional.Populasi dalam penilitan ini adalah seluruh masyarakat sejumlah 250 orang.Sampel yang digunakan dalam penelitian ini menggunakan pengambilan sampel teknik total sampel yaitu pengambilan sampel sebanyak 50 orang. Instrumen dalam penelitian ini adalah angket yang terdiri dari 20 item yang memiliki 4 pilihan ( a,b,c,d) yang sebeleumnya telah diuji validitas dan reliabilitasnya. Hasil uji persyaratan analisis data pemahaman nilai gotong royong berdistribusi normal dengan perhitungan x2hitung (39,57) < x2tabel ( 67,504) Data normalitas sikap peduli lingkungan berdistribusi normal dengan hasil perhitungan Y2hitung (39,57) < Y2tabel (67,504 )). Hasil uji linearitas data pemahaman nilai gotong royong dengan motivasi belajar adalah linear dengan persamaan Y = 941,72 +0,68 dikonsultasikan dengan Ftabel diperoleh FHhitung >Ftabel ( 4,34 >4,04).Uji kecenderungan Pemahaman nilai gotong royong (X) kategorikan cenderung sangat tinggi (30%) dan motivasi belajar (Y) kategori cenderung tinggi ( 26%). ..Hasil uji korelasi product moment yang diperoleh thitung > ttabel ( 2,966>0,679). maka hal ini menunjukkan ada hubungan yang signifikan antara pemahaman nilai gotong royong dengan sikap peduli lingkungan didesa suka kec. Tigapanah kab. Karo tahun ka 2022.
UPAYA PIHAK SEKOLAH DALAM PENANAMAN NILAI-NILAI INTEGRASI SOSIAL DENGAN TOLERANSI BERAGAMA SISWA DI SMK HARAPAN BANGSA TAHUN 2022
Authors: Singarimbun Rini Angraini , Rajagukguk Septi Revania , Purba Alimin , Naiborhu Murni 
Published: May 2023

Jenis penelitian ini adalah deskriptif korelasional. Populasi dalam penelitian ini adalah seluruh siswa kelas XII SMK Swasta Harapan Bangsa berjumlah 71 orang yang terdiri dari XII TKJ berjumlah 36 orang dan XII TBSM berjumlah 35 orang Karena populasi jumlah terbatas, maka seluruh populasi dijadikan sampel (sampel total). Instrumen yang digunakan untuk mengumpulkan data adalah angket yang berjumlah 26 item variable (X) untuk yang valid, dan 25 item variable (Y) yang valid. untuk Toleransi Beragama Siswa yang masing-masing terdiri dari 4 option sangat setuju, setuju,tidak setuju, kurang setuju yang sebelumnya telah diuji ke luar sampel untuk mengetahui validitas dan reliabilitas. Hasil uji normalitas data Upaya Pihak Sekolah dalam Penanaman Nilai-nilai Integrasi Sosial (X) di SMK Swasta Harapan Bangsa berdistribusi normal diperoleh Xh2 < Xt2 (78,77 < 91,67). Toleransi Beragama Siswa (Y) di SMK Swasta Harapan Bangsa berdistribusi normal diperoleh Xh2 < Xt2 (73,38 < 91,67). Hasil uji linearitas data Upaya Pihak Sekolah dalam Penanaman Nilai-nilai Integrasi Sosial dengan Toleransi Beragama Siswa adalah linear dengan persamaan Y = 41,87 + 0,458 X dikonsultasikan dengan Fh > Ft (46,71 > 3,98). Hasil uji kecenderungan Upaya Pihak Sekolah dalam Penanaman Nilai-nilai Integrasi Sosial (X) dikategorikan baik (32,39%). Hasil uji kecenderungan Toleransi Beragama Siswa (Y) dikategorikan baik (30,98%).Berdasarkan hasil uji korelasi X dan Y diperoleh rhitung = 0,39 dikonsultasikan dengan r pada taraf signifikan 5% dengan N = 71 diperoleh rtabel = 0,23. Karena rhitung > rtabel (0,39> 0,23) maka hal ini menunjukkan ada hubungan antara kedua variabel. Untuk menguji signifikan hubungan kedua variabel tersebut maka dilanjutkan dengan uji t. Hasil uji t diperoleh thitung= 3,56 ttabel = 1,67. Karena thitung > ttabel (3,56 > 1,66). Hal ini menunjukkan ada hubungan yang signifikan antara Upaya Pihak Sekolah dalam Penanaman Nilai-nilai Integrasi Sosial dengan Toleransi Beragama Siswa Kelas XII SMK Swasta Harapan Bangsa Tahun 2022.
بناء مسائل رياضية شكلية ذات صورة نونية باستخدام الاستقراء (كم عدد المثلثات في المثلث؟)
Authors: AbdelKabeer Salem Ahmed Abdallah 
Published: May 2023

هدف البحث بناء مسائل رياضية شكلية بصورتها النونية حيث كانت التعليمات اللفظية تبدأ بالسؤال كم عدد المثلثات المرسومة في الشكل؟ حيث هذا الشكل هو المثلث لجميع المسائل, استخدم الباحث المنهج الاستقرائي لإيجاد العلاقات العامة لحل أسئلة البحث، كما استخدم الاستقراء الرياضي لبرهنة صحة النتائج. وتوصل الباحث إلى النتائج التالية:

بناء (7) مسائل رياضية شكلية مجموع مثلثاتها تعطى بصورة نونية من الدرجة الأولى.
بناء (8) مسائل رياضية شكلية مجموع مثلثاتها تعطى بصورة نونية من الدرجة الثانية.
بناء (25) مسألة رياضية شكلية مجموع مثلثاتها تعطى بصورة نونية من الدرجة الثالثة.
بناء (3) مسائل رياضية شكلية مجموع مثلثاتها تعطى بصورة نونية من الدرجة الثالثة (فردي و زوجي).
بناء (18) مسألة رياضية شكلية مجموع مثلثاتها تعطى بصورة نونية ذات متغيرين.
بناء (25) مسألة رياضية شكلية متناظرة مجموع مثلثاتها تعطى بصورة نونية.
Vitamin D deficiency in patients with Type 2 diabetes mellitus: its association with microvascular complications
Authors: Vishnumoorthy  , Bhat Smitha 
Published: May 2023

Introduction and Aim: A worldwide epidemic, type 2 diabetes affects 382 million people. Nephropathy, neuropathy, and retinopathy are examples of microvascular consequences. According to estimates, 1 billion people, or close to 15% of the world's population, are vitamin D deficient. There is proof that inadequate vitamin D levels are linked to poor glycaemic management. However, there is a dearth of information from India on a potential connection between a vitamin D deficit and microvascular problems. Therefore, the purpose of our study was to determine if individuals with microvascular consequences of diabetes are more likely to suffer from vitamin D insufficiency.

Materials and Methods: This cross-sectional study was done on 72 diabetic subjects availing the inpatient services of Father Muller Medical College Hospital. Diabetes was diagnosed as per American Diabetes Association guidelines. Subjects were examined for presence of neuropathy, nephropathy and retinopathy by nerve conduction study, urine protein creatinine ratio and fundus examination respectively. Serum vitamin D levels were assessed. Data was recorded and statistically analysed.

Results: Seventy-two patients fulfilling the selection criteria were recruited for this study. 77.8% of subjects had poorly controlled diabetes and 66.66% had vitamin D deficiency. 39 (54.16%) of subjects had microvascular complications of which 28 (38.8%) had neuropathy, 14 (19.4%) had retinopathy and 28 (38.9%) had nephropathy. 71% of patients with microvascular complications had vitamin D deficiency.

Conclusion: Poor glycemic control is strongly correlated with vitamin D insufficiency. Individuals who suffer from microvascular problems tend to have inadequate levels of vitamin D more frequently than people without such difficulties.