bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban resilience, digital technologies, and the economic recovery of a city from the pandemic
Authors: Zou Yonghua 
Published: May 2023

AbstractThe COVID‐19 pandemic has devastated the world economy, which has made global economic recovery a considerable challenge. When a city experiences disasters, it needs to utilize innovative governance instruments, such as digital technologies, to foster economic recovery resilience. This article proposes a theoretical framework aimed at revealing the interconnection between digital technologies and economic recovery resilience, and it presents the case of Hangzhou, China, to illustrate this framework. This article finds that digital technologies can foster economic recovery resilience by sustaining a collaborative network during disasters. This article also reveals that government‐sponsored platforms, public‐private partnerships, and citizen coproduction are the underlying dynamics through which digital technologies build resilience. This article provides a nuanced understanding of how digital technologies might impact the theory and practice of economic recovery resilience in the digital era.
Geriatric Nutritional Risk Index is a predictor of tolerability of antifibrotic therapy and mortality risk in patients with idiopathic pulmonary fibrosis
Authors: Mochizuka Yasutaka , Suzuki Yuzo , Kono Masato , Hasegawa Hirotsugu , Hashimoto Dai , Yokomura Koshi , Inoue Yusuke , Yasui Hideki , Hozumi Hironao , Karayama Masato , Furuhashi Kazuki , Enomoto Noriyuki , Fujisawa Tomoyuki , Inui Naoki , Nakamura Hidenori , Suda Takafumi 
Published: May 2023

AbstractBackground and ObjectiveIdiopathic pulmonary fibrosis (IPF) is characterized by progressive lung fibrosis of unknown aetiology. Epidemiological studies have suggested that IPF progression may negatively affect nutritional status. Weight loss during antifibrotic therapy is also frequently encountered. The association of nutritional status and outcome has not been fully evaluated in IPF patients.MethodsThis retrospective multicohort study assessed nutritional status of 301 IPF patients receiving antifibrotic therapy (Hamamatsu cohort, n = 151; Seirei cohort, n = 150). Nutritional status was evaluated using the Geriatric Nutritional Risk Index (GNRI). The GNRI was calculated based on body mass index and serum albumin. The relationship between nutritional status and tolerability of antifibrotic therapy as well as mortality was explored.ResultsOf 301 patients, 113 (37.5%) had malnutrition‐related risk (GNRI < 98). Patients with malnutrition‐related risk were older, had increased exacerbations and worse pulmonary function than those without a GNRI status <98. Malnutrition‐related risk was associated with a higher incidence of discontinuation of antifibrotic therapy, particulary due to gastrointestinal disturbances. IPF patients with malnutrition‐related risk (GNRI < 98) had shorter survival than those without such risk (median survival: 25.9 vs. 41.1 months, p < 0.001). In multivariate analysis, malnutrition‐related risk was a prognostic indicator of antifibrotic therapy discontinuation and mortality, independent of age, sex, forced vital capacity, or gender–age–physiology index.ConclusionNutritional status has significant effects on the treatment and outcome in patients with IPF. Assessment of nutritional status may provide important information for managing patients with IPF.
Missing: A correlation between exchange rate misalignment and GDP growth
Authors: Goncalves Carlos , Rodrigues Mauro 
Published: May 2023

AbstractThe impact of real exchange rate movements on growth is a hotly debated issue in policy and academic circles. We provide evidence that this association is very weak for a broad panel of countries. Controlling for initial GDP, country and time fixed effects, a more depreciated currency is associated with higher growth only if the savings rate is not included as a control. Further, even if the latter is not added to the estimation, the correlation becomes insignificant when outliers or very small countries are left out. Importantly, this also holds for the specific subsample of emerging economies.
Treatment of canine periocular dermatitis with rhytidectomy (surgical face‐lift) and fluorescence photobiomodulation: A case report
Authors: Knollinger Amy , Morgan Paul , Loek Rachael , Laporte Carine 
Published: May 2023

AbstractCanine periocular dermatitis may be associated with excessive facial folds and heavy brows (EFF‐HB). There is no gold standard therapy for EFF‐HB‐associated periocular dermatitis, and conventional medical management may fail. Herein, we describe periocular fluorescence photobiomodulation and rhytidectomy as novel approaches to treat EFF‐HB‐associated periocular dermatitis refractory to medical management.
Successful management of minoxidil 5% toxicosis in 2 cats from the same household
Authors: Johnson Tyler E. , Fick Meghan E. , Haraschak Jenica L. , Vernier Mara E. , Kadotani Saki 
Published: May 2023

AbstractObjectiveTo describe the successful management of 2 cats following ingestion of minoxidil 5%.Series SummaryTwo 2‐year‐old neutered male Savannah cats were presented following suspected minoxidil 5% ingestion. Both cats developed significant myocardial injury, and clinical signs were consistent with congestive heart failure, supported by cardiac troponin I concentrations, echocardiogram, and thoracic radiographs. They required vasopressor therapy and were decontaminated with intravenous lipid emulsion therapy. Following decontamination, both cats were successfully discontinued from vasopressor therapy, and their clinical signs resolved within 24 hours. The cats were successfully discharged without long‐lasting cardiac compromise. Their echocardiograms and cardiac troponin concentration 7 weeks after discharge were within reference intervals.New or Unique InformationThis is the first detailed report of the successful management of cats following minoxidil 5% ingestion.
Amino Acid-Based Beverage Interventions Ameliorate Exercise-Induced Gastrointestinal Syndrome in Response to Exertional-Heat Stress: The Heat Exertion Amino Acid Technology (HEAAT) Study
Authors: Costa Ricardo J.S. , Henningsen Kayla , Gaskell Stephanie K. , Alcock Rebekah , Mika Alice , Rauch Christopher , Cheuvront Samuel N. , Blazy Phil , Kenefick Robert 
Published: May 2023

The study aimed to determine the effects of two differing amino acid beverage interventions on biomarkers of intestinal epithelial integrity and systemic inflammation in response to an exertional-heat stress challenge. One week after the initial assessment, participants (n = 20) were randomly allocated to complete two exertional-heat stress trials, with at least 1 week washout. Trials included a water control trial (CON), and one of two possible amino acid beverage intervention trials (VS001 or VS006). On VS001 (4.5 g/L) and VS006 (6.4 g/L), participants were asked to consume two 237-ml prefabricated doses daily for 7 days before the exertional-heat stress, and one 237-ml dose immediately before, and every 20 min during 2-hr running at 60% maximal oxygen uptake in 35 °C ambient conditions. A water volume equivalent was provided on CON. Whole blood samples were collected pre-, immediately post-, 1 and 2 hr postexercise, and analyzed for plasma concentrations of cortisol, intestinal fatty acid protein, soluble CD14, and immunoglobulin M (IgM) by ELISA, and systemic inflammatory cytokines by multiplex. Preexercise resting biomarker concentrations for all variables did not significantly differ between trials (p > .05). A lower response magnitude for intestinal fatty acid protein (mean [95% CI]: 249 [60, 437] pg/ml, 900 [464, 1,336] pg/ml), soluble CD14 (−93 [−458, 272] ng/ml, 12 [−174, 197] ng/ml), and IgM (−6.5 [−23.0, 9.9] MMU/ml, −10.4 [−16.2, 4.7] MMU/ml) were observed on VS001 and V006 compared with CON (p < .05), respectively. Systemic inflammatory response profile was lower on VS001, but not VS006, versus CON (p < .05). Total gastrointestinal symptoms did not significantly differ between trials. Amino acid beverages’ consumption (i.e., 4.5–6.4 g/L), twice daily for 7 days, immediately before, and during exertional-heat stress ameliorated intestinal epithelial integrity and systemic inflammatory perturbations associated with exercising in the heat, but without exacerbating gastrointestinal symptoms.
Examining the Effect of Time-From-Treatment on Activities of Daily Living Kinematics in Breast Cancer Survivors
Authors: Wills Rebecca A.M. , Maciukiewicz Jacquelyn M. , Mourtzakis Marina , Dickerson Clark R. 
Published: May 2023

Breast cancer affects one in 8 females with a 5-year survival rate of 89%. Up to 72% of breast cancer survivors have trouble with activities of daily living (ADL) following treatment. Increased time-from-treatment improves some measures of function, yet ADL limitations persist. Therefore, this study assessed the effect of time-from-treatment on upper extremity kinematics during ADLs in breast cancer survivors. Twenty-nine female breast cancer survivors were divided into 2 groups: <1 year (n = 12) and 1–2 years (n = 17) from treatment. Kinematics were collected during 6 ADL tasks, and humerothoracic joint angles were quantified. A 2-way mixed analysis of variance assessed the effects of time-from-treatment and arm on maximum angles for each ADL. Decreased maximum angle existed for breast cancer survivors with increased time-from-treatment during all ADLs. Breast cancer survivors in the 1–2 years group used ∼28° to 32° lower elevation, ∼14° to 28° lower axial rotation, and ∼10° to 14° lower plane of elevation range across tasks. Decreased ranges of arm movement during ADLs with increased time-from-treatment may reflect compensatory movement strategies. Recognizing this shift in strategies and accompanying underlying disease progression can help inform responses to functional performance limitations in breast cancer survivors as delayed effects are present posttreatment.
Impact of gender on clinical features and outcomes of ocular toxoplasmosis
Authors: Lyons Matilda R , Arantes Tiago , Vieira Barbara R , Furtado Joao M , Smith Justine R 
Published: May 2023

AimTo investigate the effect of gender on the clinical features and outcomes of ocular toxoplasmosis.Methods262 patients (139 women and 123 men) presenting to a tertiary referral uveitis service in Ribeirão Preto, Brazil, with serological and clinical evidence of ocular toxoplasmosis were prospectively enrolled in an observational study. Predefined data items including demographics, descriptors of uveitis and ocular toxoplasmosis, best-corrected visual acuity and ocular complications were disaggregated by gender and compared statistically.ResultsApproximately equal numbers of women and men had active versus inactive ocular toxoplasmosis. In both women and men, most infections were remotely acquired. Men were significantly more likely to present with primary active disease than women (24.4% vs 12.9%); conversely, women were significantly more likely to present with recurrent active disease than men (36.0% vs 28.5%). One toxoplasmic retinal lesion was observed in more eyes of men than eyes of women (50.4% vs 35.3%), while women’s eyes were more likely to have multiple lesions than men’s eyes (54.7% vs 39.8%). Lesions in women’s eyes were significantly more likely to occur at the posterior pole compared with those in men’s eyes (56.1% vs 39.8%). Measures of vision were similar for women and men. There were no significant differences in measures of visual acuity, ocular complications, and occurrence and timing of reactivations between the genders.ConclusionOcular toxoplasmosis has equivalent outcomes in women and men, with clinical differences in the form and type of disease, as well as characteristics of the retinal lesion.
Association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy: prospective, population based cohort study
Authors: Örtqvist Anne K. , Magnus Maria C. , Dahlqvist Elisabeth , Söderling Jonas , Johansson Kari , Sandström Anna , Håberg Siri E. , Stephansson Olof 
Published: May 2023

ObjectiveTo study the association between SARS-CoV-2 infection and newly diagnosed hypertension during pregnancy.DesignProspective, population based cohort study.SettingAll singleton pregnancies after 22 completed gestational weeks registered in the Swedish Pregnancy Register and the Medical Birth Registry of Norway, from 1 March 2020 to 24 May 2022.Participants312 456 individuals available for analysis (201 770 in Sweden and 110 686 in Norway), with pregnancies that reached 42 completed gestational weeks by the end of follow-up in the pregnancy registries, excluding individuals with SARS-CoV-2 infection before pregnancy and those with a diagnosis of pre-existing hypertension or onset of hypertension before 20 gestational weeks.Main outcome measuresNewly diagnosed hypertension during pregnancy was defined as a composite outcome of a diagnosis of gestational hypertension, pre-eclampsia, HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome, or eclampsia, from gestational week 20 to one week after delivery. The association between SARS-CoV-2 infection and hypertension during pregnancy was investigated with a stratified Cox proportional hazard model, adjusting for maternal age, body mass index, parity, smoking, region of birth, education, income, coexisting medical conditions, previous hypertension during pregnancy, number of healthcare visits during the past year, and vaccination against SARS-CoV-2. Pre-eclampsia was also analysed as a separate outcome.ResultsOf 312 456 individuals available for analysis, 8% (n=24 566) had SARS-CoV-2 infection any time during pregnancy, 6% (n=18 051) had a diagnosis of hypertension during pregnancy, and 3% (9899) had pre-eclampsia. SARS-CoV-2 infection during pregnancy was not associated with an increased risk of hypertension during pregnancy (adjusted hazard ratio 0.99, 95% confidence interval 0.93 to 1.04) or pre-eclampsia (0.98, 0.87 to 1.10). The results were similar for SARS-CoV-2 infection in all gestational trimesters and in different time periods that corresponded to dominance of different variants of the SARS-CoV-2 virus.ConclusionsThis population based study did not find any evidence of an association between SARS-CoV-2 infection during pregnancy and an increased risk of hypertension during pregnancy or pre-eclampsia.
Association between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database
Authors: Dai Lingli , Yu Yun , Wang Kunling , Hu Cuining , Wu Dan , Shan Shan 
Published: May 2023

ObjectiveTo evaluate the association of triglyceride–glucose (TyG) index on admission with outcomes of critically ill patients.DesignA retrospective study.SettingA population-based cohort study of Medical Information Mart for Intensive Care III Database (MIMIC III).ParticipantsAll intensive care unit admissions were extracted from MIMIC III.Main outcome measuresThe TyG index was calculated as ln [triglycerides (mg/dL)×glucose (mg/dL)/2]. The primary endpoint was 360-day mortality.ResultsA total of 3902 patients with an average age of 63.1±15.9 years old were enrolled, including 1623 (41.6%) women. The 360-day mortality was lower in a higher TyG group. Compared with the lowest TyG group, the HR of 360-day mortality was 0.79 (95% CI (0.66, 0.95); p=0.011) in the fully adjusted Cox model and 0.71 (95% CI (0.59, 0.85); p<0.001) in the stepwise Cox model. In the subgroup analysis, an interaction effect was detected between TyG index and gender.ConclusionsA lower TyG index was associated with the risk of 360-day mortality in critically ill patients, which could be a predictor of long-term survival of critically ill patients.
Medication use and comorbidities in an increasingly younger osteoarthritis population: an 18-year retrospective open-cohort study
Authors: Graham Jove , Novosat Tonia , Sun Haiyan , Piper Brian J , Boscarino Joseph A , Kern Melissa S , Hayduk Vanessa A , Beck Craig , Robinson Rebecca L , Casey Edward , Hall Jerry , Dorling Patricia , Wright Eric 
Published: May 2023

ObjectivesAs understanding of the pathogenesis and treatment strategies for osteoarthritis (OA) evolves, it is important to understand how patient factors are also changing. Our goal was to examine demographics and known risk factors of patients with OA over time.DesignOpen-cohort retrospective study using electronic health records.SettingLarge US integrated health system with 7 hospitals, 2.6 million outpatient clinic visits and 97 300 hospital admissions annually in a mostly rural geographic region.ParticipantsAdult patients with at least two encounters and a diagnosis of OA or OA-relevant surgery between 2001 and 2018. Because of geographic region, over 96% of participants were white/Caucasian.InterventionsNone.Primary and secondary outcome measuresDescriptive statistics were used to examine age, sex, body mass index (BMI), Charlson Comorbidity Index, major comorbidities and OA-relevant prescribing over time.ResultsWe identified 290 897 patients with OA. Prevalence of OA increased significantly from 6.7% to 33.5% and incidence increased 37% (from 3772 to 5142 new cases per 100 000 patients per year) (p<0.0001). Percentage of females declined from 65.3% to 60.8%, and percentage of patients with OA in the youngest age bracket (18–45 years) increased significantly (6.2% to 22.7%, p<0.0001). The percentage of patients with OA with BMI ≥30 remained above 50% over the time period. Patients had low comorbidity overall, but anxiety, depression and gastro-oesophageal reflux disease showed the largest increases in prevalence. Opioid use (tramadol and non-tramadol) showed peaks followed by declines, while most other medications increased slightly in use or remained steady.ConclusionsWe observe increasing OA prevalence and a greater proportion of younger patients over time. With better understanding of how characteristics of patients with OA are changing over time, we can develop better approaches for managing disease burden in the future.
Mapping the evidence on assessment of fitness to work at heights: a scoping review protocol
Authors: Swart Lyndsey , Claassen Nicolaas , Buys Tania 
Published: May 2023

IntroductionFalls from height are a leading cause of serious injury and fatality globally. In South Africa, work at heights is regulated by occupational health and safety legislation, which places responsibility on employers to ensure their workers are fit for high-risk work. There is however no formal procedure or consensus on how fitness to work at heights should be assessed. This paper presents an a priori protocol for a scoping review that seeks to identify and map the current evidence base around the assessment of fitness to work at heights. It forms the initial phase of a PhD study aimed at developing an interdisciplinary consensus statement for assessing fitness to work at heights in the South African construction industry.Methods and analysisThis scoping review will follow the Joanna Briggs Institute (JBI) scoping review framework and will be guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping reviews (PRISMA-ScR) checklist. An iterative search will be conducted in a selection of multidisciplinary databases including, Proquest Central, PubMed, Scopus, Science Direct, Web of Science, PsychINFO and Google Scholar. Thereafter, searches for grey literature will be performed in Google.com and websites of various national and international agencies, governing bodies and professional organisations with an interest in occupational health and work at heights. Where appropriate, targeted requests for clarification for further information will be undertaken with information sources. A descriptive qualitative content analysis of the results will be conducted and a level of evidence rating will be assigned to each study using the JBI approach. This will allow us to provide some commentary on the rigour of the existing evidence base.Ethics and disseminationEthics approval for the PhD study was granted by the Research Ethics Committee, Faculty of Health Sciences, University of Pretoria, ethics reference number, 486/2021. Results of the scoping review will be submitted to a scientific journal for publication.Trial registration numberThis protocol is registered on the Open Science Framework at osf.io/yd5gw.
Initial characteristics and course of disease in patients with suspected COVID-19 managed in general practice: a prospective, multicentre cohort study
Authors: Phan Tan-Trung , Mirat William , Brossier Sophie , Boutin Emmanuelle , Fabre Julie , Hoonakker Jean-Denis , Bastuji-Garin Sylvie , Renard Vincent , Ferrat Emilie 
Published: May 2023

ObjectivesTo describe and compare the initial clinical characteristics of a cohort of patients with suspected COVID-19 managed by general practitioners (GPs); to assess whether 3-month persistent symptoms were more frequent among confirmed cases than among no-COVID cases; and to identify factors predictive of persistent symptoms and adverse outcomes among confirmed cases.Design and settingA comparative, prospective, multicentre cohort study in primary care in the Paris region of France.Participants521 patients aged ≥18 with suspected COVID-19 were enrolled between March and May 2020.Outcome measuresInitial symptoms, COVID-19 status, persistent symptoms 3 months after inclusion and a composite criterion for potentially COVID-19-related events (hospitalisation, death, emergency department visits). The final COVID-19 status (‘confirmed’, ‘no-COVID’ and ‘uncertain’ cases) was determined by the GP after the receipt of the laboratory test results.Results516 patients were analysed; 166 (32.2%) were classified into the ‘confirmed COVID’ group, 180 (34.9%) into the ‘no-COVID’ group and 170 (32.9%) in the ‘uncertain COVID’ group. Confirmed cases were more likely to have persistent symptoms than no-COVID cases (p=0.09); initial fever/feeling feverish and anosmia were independently associated with persistent symptoms. At 3 months, we observed 16 (9.8%) COVID-19-related hospital admissions, 3 (1.8%) intensive care unit admissions, 13 (37.1%) referrals to an emergency department and no death. Age >70 and/or at least one comorbidity (OR 6.53; 95% CI 1.13–37.84; p=0.036), abnormalities in a lung examination (15.39; 95% CI 1.61–146.77; p=0.057) and two or more systemic symptoms (38.61; 95% CI 2.30–647.40; p=0.011) were associated with the composite criterion.ConclusionsAlthough most patients with COVID-19 in primary care had mild disease with a benign course, almost one in six had persistent symptoms at 3 months. These symptoms were more frequent in the ‘confirmed COVID’ group. Our findings need to be confirmed in a prospective study with longer follow-up.