bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite‐element simulation of in‐plane tear propagation in the dissected aorta: Implications for the propagation mechanism
Authors: Han Han , Guo Baolei , Gao Peng , Yang Fan , Sun Cuiru , Hill Nicholas A. , Liu Haofei 
Published: June 2023

AbstractComputer modeling and numerical simulation are essential for understanding the progression of aortic dissection. However, tear propagation has not been properly modeled and simulated. The in‐plane dissection propagation between concentrically distributed elastic lamellae is modeled using the cohesive zone method with a bilinear traction‐separation law. The parameters of cohesive elements are calibrated for the three modes of interfacial damage in the media, enabling quantitative predictions of in‐plane tear propagation. An idealized cylindrical tube‐shaped bilayer thick‐wall model of the aorta is employed to elucidate the influence of geometrical parameters, loading conditions and residual stress on the tear propagation. While the model is capable of replicating that deeper, larger tears are associated with lower critical pressure, new findings include: (i) Larger axial stretch leads to lower critical pressure; (ii) Increased magnitude of residual stress is associated with higher critical pressure; (iii) Pressure difference between true and false lumen alters the critical pressure; (iv) The interfacial damage is mostly opening mode in the axial direction, but shear‐dominated in the circumferential direction; (v) Damage due to the opening mode is associated with smaller fracture energy, which makes it easier to propagate than the shear and the mixed modes. (vi) The deformed shape of the tear, which is related to its geometrical features and loading conditions, modulates the critical pressure via two pathways: (a) deformed shapes are associated with specific modes of damage, which influences the critical pressure, and (b) deformed shapes modulate the critical pressure directly via geometrical constraints.
Memristive Effect in Ti3C2Tx (MXene) Polyelectrolyte Multilayers
Authors: Aglikov Aleksandr , Volkova Olga , Bondar Anna , Moskalenko Ivan , Novikov Alexander , Skorb Ekaterina V. , Smirnov Evgeny 
Published: June 2023

AbstractThe emerging novel class of two‐dimensional materials – MХenes – have attracted significant research attention. However, there are only few reports on using the most prominent member of the MXene family, Ti3C2Tx, as an active material for memristive devices within a polyelectrolyte matrix and its deposition on inert electrodes like ITO and Pt. In this study, we systematically investigate Ti3C2Tx MXenes synthesized with two classical delamination agents, such as lithium chloride and tetramethylammonium hydroxide, to identify the most suitable candidate for memristive device applications. The characteristics of memristors based on the hybrid structures consisting of MXene−polyelectrolyte multilayers, specifically polyethyleneimine (PEI) and poly(sodium 4‐styrenesulfonate) (PSS) are explored. The PEI(MXene)/PSS memristor exhibits a voltage threshold (VSET/RESET) range of 1.5–2.0 V, enabling the transition from a high‐resistive state (HRS) to a low‐resistive state (LRS), along with a significant current switching ratio of approximately two orders of magnitude. The observed VSET/RESET difference of approximately 4 V is further supported by density functional theory (DFT) calculated redox potential. These findings underscore the potential of polyelectrolyte‐based memristors, such as the in PEI−Ti3C2Tx−PSS system, in facilitating the development of highly functional, self‐assembled memristive devices with diverse applications.
The Rat Genome Database: Genetic, Genomic, and Phenotypic Data Across Multiple Species
Authors: Laulederkind Stanley J. F. , Hayman G. Thomas , Wang Shur‐Jen , Kaldunski Mary L. , Vedi Mahima , Demos Wendy M. , Tutaj Monika , Smith Jennifer R. , Lamers Logan , Gibson Adam C. , Thorat Ketaki , Thota Jyothi , Tutaj Marek A. , de Pons Jeffrey L. , Dwinell Melinda R. , Kwitek Anne E. 
Published: June 2023

AbstractThe laboratory rat, Rattus norvegicus, is an important model of human health and disease, and experimental findings in the rat have relevance to human physiology and disease. The Rat Genome Database (RGD, https://rgd.mcw.edu) is a model organism database that provides access to a wide variety of curated rat data including disease associations, phenotypes, pathways, molecular functions, biological processes, cellular components, and chemical interactions for genes, quantitative trait loci, and strains. We present an overview of the database followed by specific examples that can be used to gain experience in employing RGD to explore the wealth of functional data available for the rat and other species. © 2023 Wiley Periodicals LLC.Basic Protocol 1: Navigating the Rat Genome Database (RGD) home pageBasic Protocol 2: Using the RGD search functionsBasic Protocol 3: Searching for quantitative trait lociBasic Protocol 4: Using the RGD genome browser (JBrowse) to find phenotypic annotationsBasic Protocol 5: Using OntoMate to find gene‐disease dataBasic Protocol 6: Using MOET to find gene‐ontology enrichmentBasic Protocol 7: Using OLGA to generate gene lists for analysisBasic Protocol 8: Using the GA tool to analyze ontology annotations for genesBasic Protocol 9: Using the RGD InterViewer tool to find protein interaction dataBasic Protocol 10: Using the RGD Variant Visualizer tool to find genetic variant dataBasic Protocol 11: Using the RGD Disease Portals to find disease, phenotype, and other informationBasic Protocol 12: Using the RGD Phenotypes & Models Portal to find qualitative and quantitative phenotype data and other rat strain–related informationBasic Protocol 13: Using the RGD Pathway Portal to find disease and phenotype data via molecular pathways
Comparative efficacy of topical povidone‐iodine and chlorhexidine gel on dental plaque regrowth in toddlers: A randomized controlled trial
Authors: Basha Nour Al , Karkoutly Mawia , Bshara Nada 
Published: June 2023

AbstractObjectivesThis study aimed to compare and evaluate the efficacy of topical use of povidone‐iodine (PVP‐I) solution and chlorhexidine (CHX) gel on dental plaque regrowth after 3 and 7 days in toddlers aged 24–36 months.Materials and MethodsA randomized controlled trial that included45healthy toddlers aged 24–36 months, who were randomly assigned to three groups. The first group received a placebo (distilled water (DW)) (negative control). The second group received topical CHX gel (0.2% w/v) (positive control). The third group received topical PVP‐I solution (10% w/v). Plaque accumulation was measured at the baseline (t0), after 3 days (t1) and after 7 days (t2) using the Turesky‐modified Quigley–Hein plaque index (TMQHPI). Oral hygiene practices were prohibited during the trial period. The trial ID is ACTRN12623000567628.ResultsIn the DW group, the mean of the TMQHPI score was 1.89 ± 0.67 at t0and decreased to 1.45 ± 0.66 at t1(p = .028). Similarly, in the CHX group, the mean of the TMQHPI score was 1.83 ± 1.06 at t0and decreased to 1.02 ± 0.99 at t1(p = .033). Regarding the PVP‐I group, the mean of the TMQHPI score went from 1.84 ± 0.85 to 1.01 ± 0.61 at t1and then increased to 1.57 ± 0.74 at t2. Those changes were statistically significant (p = .001) and (p = .002), respectively. No statistically significant difference was noted between TMQHPI scores at t0(p= .789). Regarding t1and t2, no statistically significant difference was found between the three groups (p > .05).ConclusionCHX and PVP‐I efficacy lasted only for 3 days, and PVP‐I was not superior to CHX in terms of plaque control in toddlers. However, further studies are needed to determine the long‐term efficacy of these antiplaque agents in toddlers.
Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1
Authors: Gu Xin , Meng Haoyu , Peng Chengyi , Lin Shiyu , Li Baihong , Zhao Lin , Yang Xue , Wang Guangyan , Cai Wenyuan , Zhou Jiawen , Liu Shuiyuan , Wu Peng , Du Yingqiang , Jin Jianliang , Wang Xiaoyan 
Published: June 2023

BackgroundChronic changes caused by a high‐fat diet (HFD) may be associated with weakened lung function in obese patients. However, few studies have focused on the role of senescent cells in HFD‐induced pulmonary fibrosis. This study aimed to determine whether (i) obesity causes the accumulation of aging cells in the lungs, (ii) p16 accumulation in aging epithelial cells or fibroblasts exacerbates long‐term HFD‐induced senescence‐associated pulmonary fibrosis (SAPF) and (iii) p16 deletion or clearance of aging cells ameliorates HFD‐induced SAPF through inactivation of the inflammasome and metabolic remodelling.MethodsTwelve‐month old male mice of p16INK4a (hereafter p16) knockout (p16−/−) and wild‐type (WT), ApoE knockout (ApoE−/−) and ApoE−/−p16−/− were fed a HFD to induce obesity, and the effects of treatment with the senolytic drug ABT263 or the SGK1 specific inhibitor EMD638683 on fibrosis, inflammaging, gene expression, integrin‐inflammasome signalling and metabolism were examined. A549 and IMR‐90 cells were transduced with p16‐overexpressing adenovirus, and treated with palmitic and oleic acids (P&O) to induce steatosis in vitro.ResultsWe found that long‐term HFD promoted the expression of p16 and the increase of senescent cells in the lung. P16 knockout or ABT263 treatment alleviated pulmonary fibrosis, the increase of senescent cells and senescence‐associated secretory phenotype (SASP) in HFD‐fed mice, as well as in P&O‐treated A549 and IMR‐90 cells. RNA sequencing and bioinformatics analyses revealed that p16 knockout inhibited activation of the integrin‐inflammasome pathway and cellular glycolysis. Mass spectrometry, co‐immunoprecipitation and GST pull‐down assays demonstrated that p16 bound to the N‐terminal of SGK1, thereby interfering with the interaction between the E3 ubiquitin ligase NEDD4L and SGK1, and subsequently inhibiting K48‐polyubiquitin‐dependent degradation of SGK1 mediated by the NEDD4L–Ubch5 complex. EMD638683 was found to alleviate HFD‐induced pulmonary fibrosis and activation of the integrin‐inflammasome pathway.ConclusionP16 accumulation promoted activation of integrin– inflammasome pathway and cell glycolysis by binding to the N– terminal of SGK1, intefering with the interaction between the E3 ubiquitin ligase NEDD4L and SGK1, thereby inhibiting K48– polyubiquitin– dependent degradation of SGK1 mediated by the NEDD4L–Ubch5 complex. ABT263 or EMD638683 could be used as potential drugs to treat pulmonary fibrosis in obese patients.
Technical outcomes and postprocedural courses of mucosal incision‐assisted biopsy for possible gastric gastrointestinal stromal tumors: A series of 48 cases (with video)
Authors: Koizumi Eriko , Goto Osamu , Nakagome Shun , Habu Tsugumi , Ishikawa Yumiko , Kirita Kumiko , Noda Hiroto , Higuchi Kazutoshi , Onda Takeshi , Akimoto Teppei , Omori Jun , Akimoto Naohiko , Iwakiri Katsuhiko 
Published: June 2023

AbstractObjectiveMucosal incision‐assisted biopsy (MIAB) has been introduced as an alternative to endoscopic ultrasound‐guided fine needle aspiration for tissue sampling of subepithelial lesions. However, there have been few reports on MIAB, and the evidence is lacking, particularly in small lesions. In this case series, we investigated the technical outcomes and postprocedural influences of MIAB for gastric subepithelial lesions 10 mm or greater in size.MethodsWe retrospectively reviewed cases with the intraluminal growth type of possible gastrointestinal stromal tumors, in which MIAB was performed at a single institution between October 2020 and August 2022. Technical success, adverse events, and clinical courses following the procedure were evaluated.ResultsIn 48 MIAB cases with a median tumor diameter of 16 mm, the success rate of tissue sampling and the diagnostic rate were 96% and 92%, respectively. Two biopsies were considered sufficient for making the definitive diagnosis. Postoperative bleeding occurred in one case (2%). In 24 cases, surgery has performed a median of two months after MIAB, and no unfavorable findings caused by MIAB were seen intraoperatively. Finally, 23 cases were histologically diagnosed as gastrointestinal stromal tumors, and no patients who underwent MIAB experienced recurrence or metastasis during a median observation period of 13 months.ConclusionsThe data indicated that MIAB appears feasible, safe, and useful for histological diagnosis of gastric intraluminal growth types of possible gastrointestinal stromal tumors, even those of a small size. Postprocedural clinical effects were considered negligible.
Reef island evolution in a turbid‐water coral reef province of the Indo‐Pacific
Authors: Bonesso Joshua L. , Cuttler Michael V. W. , Browne Nicola K. , Mather Caroline C. , Paumard Victorien , Hiscock William T. , Callow John N. , O'Leary Michael 
Published: June 2023

AbstractCoral reef islands are vulnerable landforms to environmental change. Constructed of largely unconsolidated reef‐derived sediments, they are highly sensitive to variations in metocean boundary conditions, raising global concern about their future resilience and stability in the face of increased natural hazards, sea‐level rise and anthropogenic climate change. This study examines the evolution of an inshore turbid reef island from the southern Pilbara region of Western Australia (Indo‐Pacific) using detailed analyses of island chronostratigraphy (composition, texture) and geochronology (21 in‐situ radiometric dates) from Eva Island. Downcore, composition of island‐grade (reef‐derived) sediments were homogenous, dominated by molluscan (37%–42%) and coral (32%–37%) constituents. The 14C radiometric dating of island sediments, beachrock and coral microatolls identified five stages of island formation across changing sea‐level regimes over the mid to late Holocene: (1) limestone platform accretion at ca 6,000 cal yr BP, coinciding with reef decline or ‘give‐up’ on neighbouring Exmouth Gulf reefs; (2) sand cay (i.e. core) initiation and vertical aggregation at ca 5,000 cal yr BP during the point of sea‐level regression to current levels; (3) major accretion and lateral progradation of the island between 3,500 cal yr BP and 2,500 cal yr BP including the modification of island shorelines through alongshore reworking of sediment; (4) lateral accretion and minor expansion to the north and formation of beachrock pavement between 2,500 and 650 cal yr BP; and (5) planform adjustment (erosion of the north‐west island) and backstepping under stabilised sea levels over the past 650 years. While this model is comparative to studies on island formation following incremental sea‐level fall following the mid‐Holocene highstand, it demonstrates active landform readjustment under stabilised sea levels over the past 2,000 years, probably the influence of local‐scale metocean boundary conditions within climate windows across the mid to late Holocene period (i.e. independent of sea‐level fluctuations). Importantly, while sediment production rates are predicted to be lower in turbid‐water reef systems than clear water, Eva Island shows no change in carbonate producers (i.e. proportion of mollusc and coral) over the course of island building, indicating the carbonate factory has not experienced significant adjustments in reef ecology, but has remained stable despite low water quality.
Predicting diabetic foot ulceration using routinely collected data in a foot clinic. What level of prognostic accuracy can be achieved?
Authors: Naemi Roozbeh , Balasubramanian Gayathri , Darvel Tracey , Chockalingam Nachiappan 
Published: June 2023

AbstractThis study aimed to investigate the efficacy of using routinely collected clinical data in predicting the risk of diabetic foot ulcer (DFU). The first objective was to develop a prognostic model based on the most important risk factors objectively selected from a set of 39 clinical measures. The second objective was to compare the prediction accuracy of the developed model against that of a model based on only the 3 risk factors that were suggested in the systematic review and meta‐analyses study (PODUS). In a cohort study, a set of 12 continuous and 27 categorical data from patients (n = 203 M/F:99/104) who attended a specialised diabetic foot clinic were collected at baseline. These patients were then followed‐up for 24 months during which 24 (M/F:17/7) patients had DFU. Multivariate logistic regression was used to develop a prognostic model using the identified risk factors that achieved p < 0.2 based on univariate logistic regression. The final prognostic model included 4 risk factors (Adjusted‐OR [95% CI]; p) in total. Impaired sensation (116.082 [12.06–1117.287]; p = 0.000) and presence of callus (6.257 [1.312–29.836]; p = 0.021) were significant (p < 0.05), while having dry skin (5.497 [0.866–34.89]; p = 0.071) and Onychomycosis (6.386 [0.856–47.670]; p = 0.071) that stayed in the model were not significant. The accuracy of the model with these 4 risk factors was 92.3%, where sensitivity and specificity were 78.9%, and 94.0% respectively. The 78.9% sensitivity of our prognostic 4‐risk factor model was superior to the 50% sensitivity that was achieved when the three risk factors proposed by PODUS were used. Also our proposed model based on the above 4 risk factors showed to predict the DFU with higher overall prognostic accuracy. These findings have implications for developing prognostic models and clinical prediction rules in specific patient populations to more accurately predict DFU.
Vulnerability of sea turtle nesting sites to erosion and inundation: A decision support framework to maximize conservation
Authors: Gammon Malindi , Whiting Scott , Fossette Sabrina 
Published: June 2023

AbstractSandy beaches provide essential nesting habitats for sea turtles but are threatened globally by a rapidly changing climate. Identifying which nesting sites are at the greatest risk from erosion and inundation remains an important goal of sea turtle conservation globally. Yet, efforts to identify at‐risk sites have been hindered by the ability to model complex processes and incomplete information on nesting distribution and abundance. To assess the erosion and inundation risk to the reproductive success of a discrete genetic stock of flatback turtles (Natator depressus) across its nesting range in the Pilbara region of Western Australia, we used the Integrated Valuation of Ecosystem Services and Trade‐offs (InVEST) Coastal Vulnerability Model. A relative exposure index was calculated for 402 nesting beaches in terms of six geophysical variables: wind and wave exposure, surge potential, relief, observed sea level rise, and coastal geomorphology, and coupled with published information on the distribution and abundance of turtle tracks in the region. The majority of beaches (74%) had intermediate to high exposure. In particular, 36% of beaches with a high abundance of flatback tracks (the top 25% of the frequency distribution) had a high exposure (the top 25% of the frequency distribution). This suggests that coastal exposure is a key vulnerability to the reproductive success of sea turtles that nest in this region. Promisingly, five beaches with a high abundance of turtle tracks also had a low exposure (bottom 25% of the frequency distribution), and these beaches may be critical for the long‐term resilience of the stock against sea level rise and severe storms. Exposure varied across nesting sites, and the approach presented here allows for a rapid and broadscale assessment of relative erosion and inundation risks at a scale most relevant to management.
A quantitative model to ensure capacity sufficient for timely access to care in a remote patient monitoring program
Authors: Chang Annie , Gao Michael Z. , Ferstad Johannes O. , Dupenloup Paul , Zaharieva Dessi P. , Maahs David M. , Prahalad Priya , Johari Ramesh , Scheinker David 
Published: June 2023

AbstractIntroductionAlgorithm‐enabled remote patient monitoring (RPM) programs pose novel operational challenges. For clinics developing and deploying such programs, no standardized model is available to ensure capacity sufficient for timely access to care. We developed a flexible model and interactive dashboard of capacity planning for whole‐population RPM‐based care for T1D.MethodsData were gathered from a weekly RPM program for 277 paediatric patients with T1D at a paediatric academic medical centre. Through the analysis of 2 years of observational operational data and iterative interviews with the care team, we identified the primary operational, population, and workforce metrics that drive demand for care providers. Based on these metrics, an interactive model was designed to facilitate capacity planning and deployed as a dashboard.ResultsThe primary population‐level drivers of demand are the number of patients in the program, the rate at which patients enrol and graduate from the program, and the average frequency at which patients require a review of their data. The primary modifiable clinic‐level drivers of capacity are the number of care providers, the time required to review patient data and contact a patient, and the number of hours each provider allocates to the program each week. At the institution studied, the model identified a variety of practical operational approaches to better match the demand for patient care.ConclusionWe designed a generalizable, systematic model for capacity planning for a paediatric endocrinology clinic providing RPM for T1D. We deployed this model as an interactive dashboard and used it to facilitate expansion of a novel care program (4 T Study) for newly diagnosed patients with T1D. This model may facilitate the systematic design of RPM‐based care programs.
The high‐frequency phenomenon of copper clad aluminum wires which are lower the alternating current resistance than copper solid wires, and the application of copper clad aluminum wires to the electrical equipment
Authors: Ueda Katsuhiko , Hung Chefen 
Published: June 2023

AbstractThe paper is proposed approximate formulas of the ac resistance of lead wires and coils which made by using copper clad aluminum (CCA) wires. There are the frequency range that the ac resistance of CCA wires is lower than it of cupper solid wires for lead wires and coils of an electrical equipment. It is shown that the application of CCA wires is economical as comparing with copper solid wires, if the design is due to successful calculation in the electrical equipment. The measured resistance is compared with the formula. CCA wires is an example of multiple conductors which shall be expected to apply in future.
Pyrazine Derivative as Supramolecular Host for Immobilization of Palladium Nanoparticles for Efficient Suzuki Coupling
Authors: Sharma Sonia , Kumar Manoj , Bhalla Vandana 
Published: June 2023

AbstractPalladium nanoparticles (NPs) have been extensively explored as unique catalyst for carbon‐carbon coupling reactions. Nonetheless, because of extreme tendency of nanoparticles to undergo agglomeration, the immobilization of these metal NPs on organic frameworks is an important area of research. The present investigation demonstrates the synthesis of pyrazine derivative PYZ‐TA as a supramolecular host for holding co‐released Pd NPs derived from the original catalyst (Pd(II)) under standard Suzuki coupling. Unprecedent, physical bars are not required to capture Pd NPs within the pores of supramolecular host. The as obtained catalyst PYZ‐TA@Pd exhibits high potential to undergo self‐assembly in solid as well as in liquid state. The PYZ‐TA@Pd ensemble shows high catalytic activity and recyclability (up to seven cycles) in Suzuki‐Miyaura coupling reactions using low palladium loading and provides the corresponding products in excellent yields (up to 98 %). Therefore, this study provides an efficient strategy to develop an easy to synthesize palladium centered solid catalyst through coordination between organic host and Pd NPs.