bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression patterns of CD147 impact the prognosis of liver hepatocellular carcinoma
Authors: Xu Ji-yun , He Hong-Jie , Wu Peng , Li Wen-bin 
Published: March 2023

Abstract
Objectives
1) To explore the pattern of CD147 expression and its applicability in the prognosis of liver hepatocellular carcinoma (LIHC).
2) To establish hazard ratio and probability points for predicting the prognosis of HCC by correlating CD147 expression with clinical characteristics.
3) To determine if CD147 can be a reliable biomarker in LIHC prognosis.
Methods
CD147 expression profile in LIHC and corresponding clinical data were obtained from The Cancer Genome Atlas (TCGA) database. The expression patterns of CD147 were then validated by analyzing data from the Gene Expression Omnibus (GEO) database. In addition, CD147 Immunohistochemistry (IHC) in LIHC was obtained from the Human Protein Atlas (HPA). CD147 expression patterns and clinical characteristics in the prognosis of HCC were analyzed by accessing the UALCAN web resource. Accuracy, sensitivity, and specificity of the CD147 expression profile in predictive prognosis were determined by the Time-dependent Receiver Operating Characteristic (ROC) curves. Kaplan-Meier curves were plotted to estimate the hazard ratio (HR) of survival in LIHC. Univariate and multivariate Cox regression proportional hazards analyses of CD147 expression levels and clinical characteristics as prognostic factors of LIHC were performed. Nomograms were used to establish probability points and predict prognosis.
Results
Data from TCGA and GEO databases revealed that CD147 was significantly overexpressed in LIHC (p = 1.624e-12 and p = 1.2e-05), respectively. The expression of CD147 and prognosis of LIHC were significantly correlated with the clinical characteristicsof LIHC as per the data from the UALCAN web resource (p < 0.05). Kaplan-Meier analysis of CD147 expression in LIHC revealed that the high expression groups showed poor prognosis and an HR of survival > 1 [(Log-rank test, p = 0.000542, HR (in high expression groups) = 1.856, 95% CI (1.308, 2.636)]. ROC curves were plotted to analyze the 1-year, 3-year, and 5-year survival rates, the Area under the ROC curve (AUC) values were 0.675, 95% CI (0.611–0.74); 0.623, 95% CI (0.555–0.692); and 0.664, 95% CI (0.582–9.745) respectively. Univariate Cox analysis of CD147 expression and clinical characteristics of LIHC, and multivariate Cox analysis of CD147 patterns and pTNM-stage showed significant differences [(Uni-Cox, p = 0.00013, HR = 1.42437, 95% CI (1.8838, 1.70723) and p = 0.00066, HR = 1.37612, 95% CI (1.14521, 1.65359); Multi-Cox, p = 0.00578, HR = 1.50746, 95% CI (1.12637, 2.0175) and p= 0.00336, HR = 1.44319, 95% CI (1.12941, 1.84415)]. Nomograms were plotted to establish the probability points and predict prognosis, the total points ranged from 0 to 180, and the C-index value was 0.673, 95% CI (0.6–1.0), p < 0.01.
Conclusions
Overexpression of CD147 was correlated with poor prognosis in LHIC. CD147 expression profile combined with clinical characteristics can reliably predict the prognosis of HCC. CD147 can serve as a biomarker to predict the prognosis of HCC.
The expression and prognostic significance of CCNB1 in colorectal cancer based on TCGA database
Authors: Chen Guo , Wang Feiqing , Tian Tingting , Yang Bin , Yang Zhu , Tang Dongxin 
Published: March 2023

Abstract
Background
Numerous studies have shown that cell cycle-associated protein B1 (Cyclin B1, CCNB1) is overexpressed in many cancers and is involved in cancer cell growth, differentiation, apoptosis, and metastasis. However, the biological functions and molecular mechanisms of CCNB1 in colorectal cancer (CRC) still remain unclear.
Methods
Herein, the HPA database and the UCSC genomic database were used to analyze the mRNA and protein expression levels of CCNB1 in different tissues of humans or vertebrates. The TIMER database was used to evaluate the expression of CCNB1 in various cancer tissue samples and adjacent normal tissue. R statistical software (version 4.2.1) was employed to analyze the relationship between CCNB1 expression and clinicopathological characteristics in the TCGA database. Kaplan-Meier survival curve and Cox regression were performed to evaluate the prognostic value. Receiver operating characteristic (ROC) curve analysis was applied to assess the diagnostic value of CCNB1. Functional enrichment analysis of CCNB1 and its co-expressed genes was performed to explore the potential molecular mechanisms of CCNB1 in CRC. The correlation of critical cell-cycle regulators and the protein-protein interaction (PPI) network of CCNB1 and CRC was established through the STRING (Search Tool for the Retrieval of Interacting Genes) website and GEPIA database.
Results
Significant upregulation of CCNB1 was observed in a variety of tumor tissues, with limited tissue specificity and tumor specificity. TCGA database and immunohistochemistry data demonstrated that CCNB1 expression was significantly upregulated in CRC tumor tissues. In addition, CCNB1 expression was correlated with the clinical stage and TNM stage. The progression-free survival (PFS) was considerably improved in the CCNB1 high-expression group. Univariate and multifactorial Cox analysis indicated that CCNB1 could not be used as an independent prognostic factor for patients with CRC. Moreover, we found that genes such as BCAS3, ZBTB4, PTTG1, H2AZ1, LRP1B, KCNJ9, and SCARNA7 could be potential targets for regulating CCNB1. The gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) analyses revealed that CCNB1 was implicated in multiple cancer-related signaling pathways and biological processes. Meanwhile, CCNB1 expression was significantly correlated with the immune infiltrating levels of diverse immune markers. CCNB1 expression was positively correlated with tumor mutation burden and negatively correlated with several immune checkpoint genes. In addition, the efficacy of chemotherapeutic medicines such as 5-Fluorouracil, bexarotene, bleomycin, camptothecin, and cisplatin significantly differed between the high and low CCNB1 expression groups.
Conclusion
CCNB1 could be a promising biomarker for predicting the diagnosis and prognosis of CRC patients and a potential novel molecular target for tumor immunotherapy.
Synthesis and characterization a new polyoxomolybdate C34H114Fe2Mo12N18Na2O66 and study of its catalytic activity in the production of 1,2,3-triazoles
Authors: Yousofvand Asmaa , Amini Mojtaba , Hosseinifardc Mojtaba , janczak Jan 
Published: March 2023

AbstractA new polyoxomolybdate with a formula of [(C6H12N4-CH3)2Na2(H2O)8](C6H12N4-CH3)2[(H0.5)N(CH2O)3FeMoO18.5(OH)2.5]2·10H2O(1)was synthesized. The structure of the synthesized polyoxomolybdate was investigated by single crystal X-ray diffraction analysis and several other identification techniques such as FT-IR and EDX analysis. It was confirmed that each unit cell of1contains one cation [(C6H12N4-CH3)2Na2(H2O)8]4+and two hexamethylenetetramine cations (C6H12N4-CH3)+, two polyanions [(H0.5)N(CH2O)3FeMoO18.5(OH)2.5]3-with ten water molecules in the crystal lattice. In polyanion, molybdenum metals are bonded to two terminal oxygen atoms and two μ2- (Mo-Mo) and μ3- (Mo-Fe-Mo) bridging oxygen atoms. Iron in the center of the polyanion1is also surrounded by three deprotonated oxygens of trimethanolamine ligand and three μ3- (Mo-Fe-Mo) bridging oxygen atoms. This new polyoxomolybdate was used as an efficient catalyst in the azide-alkyne cycloaddition reaction to produce various 1,2,3-triazoles with high yields.
Two Parallel PageRank Algorithms via Improving Forward Push
Authors: Zhang Qi , Tang Rongxia , Yao Zhengan , Liang Jun 
Published: March 2023

Abstract
PageRank, originally designed to rank web pages, has been widely applied in various fields. With the increasing scale of graphs, accelerating PageRank computation has become an urgent need, and designing parallel algorithms is a feasible solution. In this paper, we propose two parallel PageRank algorithms, IFP1 and IFP2, which are improvements upon the state-of-the-art Personalized PageRank algorithm, Forward Push. Theoretical analysis indicates that IFP1 can take advantage of the DAG structure of a graph, where dangling vertices can improve convergence rates and unreferenced vertices can decrease computation amount. IFP2 further improves upon IFP1 by pushing mass to dangling vertices only once but rather many times, decreasing computation amount even further. Experiments on six datasets illustrate that both IFP1 and IFP2 outperform the Power method, with IFP2 reaching up to 49 times faster than Power method with 38 parallelism.
Surgical ablation for atrial fibrillation: impact of diabetes mellitus
Authors: Kogan Alexander , Grupper Avishay , Sabbag Avi , Ram Eilon , Jamal Tamer , Nof Eyal , Fisman Enrique (Zvi) , Levin Shany , Beinart Roy , Frogel Jonathan , Raanani Ehud , Sternik Leonid 
Published: March 2023

Abstract
Background: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Surgical ablation or "maze procedure" is an option for patients with (AF) undergoing concomitant or isolated cardiac surgery. The aim of this study was to evaluate the impact of DM on early and long-term outcomes of patients following surgical AF ablation.
Methods: We performed an observational cohort study in Israel’s largest tertiary care center. All data of patients who underwent surgical AF ablation, between 2006 and 2021 were extracted from our departmental database. Patients were divided into Group I (non-diabetic patients) and Group II (diabetic patients). We compared the two groups with respect to freedom from recurrent atrial arrhythmia, and mortality rate.
Results: The study population included 606 patients. Group I (non-DM patients), consisting of 484 patients, and Group II (DM type 2 patients), comprised 122 patients. Patients with DM were older, had more hypertension and incidence of cerebrovascular accident (CVA)/transient ischemic attack (TIA), higher EuroSCORE (p <.05 for all), and a longer bypass time - 130±40 vs. 122±36 min (p=0.028). The mean follow-up duration was 39.0 ± 22.7 months. Freedom from atrial fibrillation was similar between the non-DM and DM groups after a 1-year follow-up, 414 (88.2%) vs. 101 (87.1%) (p = 0.511), after a 3-year follow-up, 360 (86.3%) vs. 84 (79.9%) (p = 0.290) and after a 5-year follow-up, 226 (74.1%) vs. 55 (71.5%) (p = 0.622) respectively. Furthermore, 1- and 3-year mortality was similar between non-DM and DM groups, 2.5% vs. 4.9%, (p = 0.226) and 5.6% vs. 10.5% (p = 0.076) respectively. 5-year mortality was higher in Group II (DM patients) compared with Group I (non-DM patients), 11.1% vs. 23.4% (p = 0.009).
Conclusion: Surgical ablation had a high success rate, with freedom from recurrent atrial arrhythmia at 1- 3- and 5- years follow-up in both the DM and non-DM groups. Furthermore,1- and 3-year mortality after surgical ablation was also similar in both groups. However, 5-year mortality was higher in the DM group.
Metal Matrix Composite Fabricated from Electrospun PAN, EGNS/PAN Nanofibers and AL 5049 Alloy by Using Friction Stir Processing
Authors: sobhy saleh , Elbadawi Rehab E. , Zoalfakar Said H. 
Published: March 2023

Abstract
This work is an attempt to fabricate aluminum (AA 5049) matrix composites (AMCs) reinforced with electrospun polyacrylonitrile (PAN) nanofibers and consisting of exfoliated graphite nanosheets (EGNS/PAN) by utilizing friction stir processing (FSP) to improve the mechanical characteristics of AA 5049. PAN and EGNS/PAN nanofibers were fabricated using the electrospinning technique. The average diameter of the electrospun PAN nanofibers is 195 ± 57 nm, and after EGNS incorporation is 180 ± 68nm. The incorporation of nanofiber reinforcement can enhance the mechanical characteristics of AA5049. The mechanical characteristics of AA5049 can be enhanced by the procedure of incorporating nanofibers, making them an ideal choice for applications in the automotive and aerospace industries. PAN and EGNS/PAN nanofiber reinforcement enhanced the hardness to 89 and 98 Hv, respectively. Also, the ultimate tensile strength was raised to 291 MPa and 344 MPa, respectively.
WITHDRAWN: Impact of E-nam on Organic Agriculture Farmers' Economic Growth: a Smart-pls Approach
Authors: SARAT SARAT KUMAR SAMANTARAY , FARHAN MOHD , PRITPAL PRITPAL SINGH , Amit Amit Kakkar 
Published: March 2023

Abstract
To achieve the aim of doubling organic agriculture farmers' income, new sources of revenue and improved possibilities must be identified. The online digital market attempts to reduce transaction costs, bridge information gaps, and facilitate market access for organic agriculture farmers and other stakeholders. To improve efficiency in the current system, the government of India (GOI) developed a National Agriculture Market in 2016 by merging all of the country's existing APMCs marketplaces through a shared electronic platform known as e-NAM. The e-NAM is a mandatory delivery-based trading platform that may aid in lowering the cost of intermediation and increasing organic agriculture farmers' price realization by boosting marketing efficiency and introducing transparency to agriculture marketing. The current study was undertaken in six E-NAM mandis located in four districts of Odisha to evaluate the efficiency of e-NAM, particularly on farmer involvement and the online pricing value system as a result of e-NAM. Data was obtained from organic agriculture farmers, merchants, and mandi authorities during a field survey, as well as live trading on e-NAM commodities prices. The current study has a broader marketing coverage since it identifies farmer concerns and their perspectives in the overall marketing of various goods and also exposes facts about organic agriculture farmers having difficulties in marketing their output through e-NAM.
The genomic domestication landscape is orchestrated by transcription factors regulating brain and craniofacial development
Authors: Benítez-Burraco Antonio , Uriagereka Juan , Nataf Serge 
Published: March 2023

Abstract
Domestication transforms once wild animals into tamed animals that can be then exploited by humans. The process entails modifications in the body, cognition, and behavior that are essentially driven by differences in gene expression patterns. Although genetic and epigenetic mechanisms were shown to underlie such differences, less is known about the role exerted by trans-regulatory molecules, notably transcription factors (TFs) in domestication. In this paper, we conducted extensive in silico analyses aimed to clarify the TF landscape of mammal domestication. We first searched the literature, so as to establish a large list of genes selected with domestication in mammals. From this list, we selected genes experimentally demonstrated to exhibit TF functions. We also considered TFs TFs displaying a statistically significant number of targets among the entire list of (domestication) selected genes. This workflow allowed us to identify 5 candidate TFs (SOX2, KLF4, MITF, NR3C1, NR3C2) that were further assessed in terms of biochemical and functional properties. We found that such TFs-of-interest related to mammal domestication are all significantly involved in the development of the brain and the cranio-facial skull, as well as the immune response and lipid metabolism. A ranking strategy, essentially based on a survey of protein-protein interactions datasets, allowed us to identify SOX2 as the main candidate TF involved in domestication-associated evolutionary changes. These findings should help to clarify the molecular mechanics of domestication and are of interest for future studies aimed to understand the behavioral and cognitive changes associated to domestication.
Validation of a shortened MR imaging protocol for pediatric spinal pathology
Authors: Wu Winnie Shu Yu , Miller Elka , Hurteau-Miller Julie , Thipse Madhura , Kapoor Cassandra , Webster Richard , McAuley David , Tu Albert 
Published: March 2023

Abstract
Objective
Conventional pediatric spine MRI protocols have multiple sequences resulting in long acquisition times. Sedation is consequently required. This study evaluates the diagnostic capability of a limited MRI spine protocol for selected common pediatric indications.
Methods
Spine MRIs at CHEO between 2017 and 2020 were reviewed across pediatric patients younger than four years old. Two blinded neuroradiologists reviewed limited scan sequences and results were independently compared to previously reported findings from the complete imaging series. T2 sagittal sequences from the craniocervical junction to sacrum and T1 axial sequence of the lumbar spine constitute the short protocol, with the outcomes of interest being cerebellar ectopia, syrinx, level of conus, filum < 2mm, fatty filum, and spinal dysraphism.
Results
105 studies were evaluated in 54 male and 51 female patients (mean age 19.2 months). The average combined scan time of the limited sequences was 15 minutes compared to 35 minutes for conventional protocols (delta = 20 minutes). The average percent agreement between full and limited sequences was > 95% in all but identifying a filum < 2mm, where the percent agreement was 87%. Using limited MR sequences had high sensitivity (> 0.91) and specificity (> 0.99) for the detection of cerebellar ectopia, syrinx, fatty filum, and spinal dysraphism.
Conclusion
This study demonstrates that selected spinal imaging sequences allow for consistent and accurate diagnosis of specific clinical conditions. A limited spine imaging protocol has potential as a screening test to reduce the need for full sequence MRI scans. Further work is needed to determine utility of selected imaging for other clinical indications.
Crystallographic Orientation-Dependent Resistive Switching in Ga2O3 Thin Films
Authors: Sun Kai , Lei Ming , Yuan Lei , Peng Bo , Yu Miao , Xie Xin-ming , Zhang Yu-ming , Jia Ren-xu 
Published: March 2023

Abstract
Resistive random-access memories (RRAMs) based on wide-bandgap oxides is not only a promising candidate for next-generation non-volatile storage technology but also a suitable family of materials capable of neural network computing. However, the exact mechanism of resistive switching (RS) is not yet clearly understood. In this paper, we investigate Ga2O3-based RRAMs to understand the microscopic-level RS behavior and its relation to the actual process. We find that the oxygenation process during magnetron sputtering affects the crystallization orientation of Ga2O3 thin films. The XRD analysis reveals that the crystalline orientation of Ga2O3 films deposited with O2 flow is [006], and the prepared devices exhibit a lower operating voltage, a higher high/low resistance state ratio, and a more concentrated distribution. By using first-principles calculations and the climbing image nudged elastic band (CI-NEB) method, we show that the oxygen vacancies of the [006] crystalline Ga2O3 films only need to migrate in the (110) plane to form conductive filaments with an energy barrier of 0.65 eV. In contrast, [122] crystalline Ga2O3 films require additional movement in the Z-axis direction, resulting in a much higher energy barrier. Our results can be utilized to modulate the operating voltage and improve the endurance of Ga2O3-based RRAMs.
Results after intraoperative open and endovascular revascularization of acute mesenteric ischemia
Authors: Kapalla Marvin , Choubey Rahul , Weitz Jürgen , Reeps Christian , Wolk Steffen 
Published: March 2023

Abstract
Background: Acute mesenteric ischemia (AMI) is a dreaded condition with a difficult diagnosis and high mortality. Due to different baseline situations, the frequently performed comparison between endovascular and open surgical treatment is interfered by selection bias. The purpose of this study was to review outcomes in AMI treatment with an open or endovascular approach in association with laparotomy to analyze risk factors of mortality for proper risk stratification.
Methods: The clinical data of 74 patients treated for AMI from 2007 to 2021 were retrospectively reviewed and compared. In-hospital mortality was appointed as the primary study endpoint. Risk factors for mortality were identified by using univariate and multivariate analysis.
Results: In total, 61 patients (82%) were treated open surgically (OT) and, 13 patients (18%) with an endovascular approach (ET) in combination with laparatomy. The etiology of AMI was 53% thrombotic and 47% embolic occlusion. The total in-hospital mortality manifested at 43% (n=32) (OT 41% vs. ET 53.8%; P=0.54). As independent risk factors for in-hospital mortality pneumatosis intestinalis (P=0.01), increased lactate concentration (P=0.04) and ischemic intestinal sections (P=0.01) were identified. Additionally, on univariate analysis patient age, congestive heart failure (> NYHA II) and atrial fibrillation were related with higher mortality.
Conclusions: Morbidity and mortality of AMI remainsat a high level. Conventional open or intraoperative endovascular therapy achieved similar results in patients with indication for laparotomy. Advanced disease stage with ischemic intestinal sections at presentation and cardiovascular comorbidities were associated with adverse outcome.
FLORA: Fuzzy Logic - Objective Risk Analysis for Intrusion Detectionand Prevention
Authors: Bamhdi Alwi 
Published: March 2023

Abstract
The rapid take-up of cloud computing and theevolution of the Internet of Things (IoT) has had an alarming impact on society globally in recent years, which hasled to inescapable and relentless cyber-attacks against dataand information systems, posing a devastating safety, protection and security impact with serious consequences in allsectors depending on Information Communication Technology (ICT). It is only a matter of time before the security ofdata, information systems, and cloud computing platformsand their supporting networks, become increasingly significant as high-value assets, as the number of security breachesescalates to new heights. Invasive and continuous cyber-attacks on information systems and critical infrastructurescontinuously cause damaging impacts across multiple sectors. Traditional protection mechanisms like firewalls andencryption systems have proved vulnerable and to a large extent ineffective to counter sophisticated cyber-attacks. Datasecurity and information systems require a highly protectiveand safer security system such as an Intrusion Detection andPrevention System (IDPS) to minimize risk to its absoluteminimum. A well-formulated and designed security systemwith the correct set of policies and strategies for an IDPS hasalso been deemed an extremely useful mechanism in monitoring and recording digital forensic evidence, which can beused in legal prosecution proceedings in different jurisdictions. Such an IDPS can also provide a high detection rate indetecting various classes of cyber-attack attempts. However,in many cases, it is apparent that the performance of IDPSis hampered by an increasing volume of false alarm rates ifit is not properly designed. This indicates a serious concernin ICT security systems since every false alarm can result ina severe impact on the system and its performance. This research proposes the implementation of a unique Fuzzy Logic-Objective Risk Analysis (FLORA) novel technique that canae-mail: ambamhdi@uqu.edu.sareduce false alarm rates during intrusion detection activitiesto a minimum, yet maintain total security at a high level against serious attacks. The highest percentage of error in fuzzymodel prediction is rated at 0.32%. The low level of errorsshows that fuzzy logic predicting countermeasure results isvery close to the actual experimental countermeasure values.The FLORA model accuracy with a rate of 90.11% demonstrates the vulnerability of a system with a very high levelof confidence, and on average it detects DDoS attacks with90.58% accuracy compared to other forms of DDoS attackdetection systems.