bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Sustainable and Equitable Blue Recovery to the COVID-19 Crisis
Authors: Northrop Eliza , Konar Manaswita , Frost Nicola , Hollaway Elizabeth 
Published: May 2023

AbstractA healthy ocean is the foundation for prosperous, healthy and vibrant economies. There is an unprecedented opportunity, through global stimulus and recovery responses to the COVID-19 crisis, to reset and rebuild economic activities in ways that will ensure a more sustainable, equitable and resilient ocean economy fit for everyone’s future. This report provides a roadmap to achieve this vision.
The Ocean Genome: Conservation and the Fair, Equitable and Sustainable Use of Marine Genetic Resources
Authors: Blasiak Robert , Wynberg Rachel , Grorud-Colvert Kirsten , Thambisetty Siva , Bandarra Narcisa M. , Canário Adelino V. M. , Silva Jessica da , Duarte Carlos M. , Jaspars Marcel , Rogers Alex D. , Sink Kerry , Wabnitz Colette C. C. 
Published: May 2023

AbstractThe ‘ocean genome’ is the foundation upon which all marine ecosystems rest and is defined here as the ensemble of genetic material present in all marine biodiversity, including both the physical genes and the information they encode. The dynamics of the ocean genome enable organisms to adapt to diverse ecological niches and changing environmental conditions. The ocean genome also determines the productivity and resilience of biological resources, including fisheries and aquaculture, which collectively support global food security, human well-being and a sustainable ocean economy.
National Accounting for the Ocean and Ocean Economy
Authors: Fenichel Eli P. , Milligan Ben , Porras Ina , Addicott Ethan T. , Árnasson Ragnar , Bordt Michael , Djavidnia Samy , Dvarskas Anthony , Goldman Erica , Grimsrud Kristin , Lange Glenn-Marie , Matuszak John , Muawanah Umi , Quaas Martin , Soulard François , Vestergaard Niels , Zhang Junjie 
Published: May 2023

AbstractRealising the goal of the High Level Panel for a Sustainable Ocean Economy (Ocean Panel) to catalyse the transition to a sustainable ocean economy depends on coordinating and managing humanity’s relationship with the ocean and the broader environment. This task requires organising information that currently is often disorganised, spread across multiple government agencies or in a few cases not yet available. National ocean accounts would provide countries with the information needed to guide ambitious and broad- based plans to develop ocean economies and to capitalise on marine opportunities (European Union Directorate-General of Maritime Affairs and Fisheries and Joint Research Centre 2018; Economist Intelligence Unit 2015), while protecting the ocean for generations to come in accordance with the Sustainable Development Goals, most notably SDG 14, ‘Life below Water’. The ‘blue-ing’ of the ocean economy—or making the ocean economy sustainable—requires ensuring that the ocean continues to provide at least the current levels of opportunity; ‘measuring the ocean economy gives a country a first-order understanding of the economic importance of the seas’ (Economist Intelligence Unit 2015). The old adage goes that ‘what gets measured, gets managed’, or more accurately, that ‘if you cannot measure it, you cannot improve it’. Sound decision- making requires organised information.
Theoretical Foundations and a Transdisciplinary Concept of Hope
Authors: Krafft Andreas M. , Guse Tharina , Slezackova Alena 
Published: May 2023

AbstractThe current chapter has the primary purpose of laying the theoretical grounds on which the cross-cultural empirical research program of the Hope Barometer between 2017 and 2021 was developed and executed. The two main goals of this chapter correspond to the inter- and transdisciplinary methodology applied in our work. The first goal is to give a brief interdisciplinary overview of psychological, philosophical, and theological theories presenting different perspectives from which the existential phenomenon of hope has been studied. Following previous research, hope will be examined along six general dimensions, which highlight the nature of hope as cognition, as affect, as behavior, as a social phenomenon, as a virtue, and from a religious perspective. Based on the similarities and complementary views of these different conceptualizations of hope, a basic transdisciplinary concept or model of hope will be presented. The proposed concept should do justice to the essence of hope, taking into account the diversity of situations in which people might hope and being sensitive to different cultural backgrounds. Our conceptualization of hope contains three fundamental elements, which are (1) a wish or desire for a valuable good, (2) the belief that the realization of this wish is possible but uncertain or even unlikely, and (3) the trust in the availability of current or future internal and external resources which can facilitate the fulfillment of the hoped-for good in the face of obstacles and setbacks. We understand wish, belief, and trust as the universal elements in the process of hoping. In concrete situations and different cultural contexts, these three elements can assume different forms and characteristics related to those mentioned above cognitive, affective, behavioral, social, religious, and value dimensions. The singular elements and dimensions serve as the core research domains, which will be elaborated on in detail in the following chapters of the book.
The isospin-3 three-particle K-matrix at NLO in ChPT
Authors: Baeza-Ballesteros Jorge , Bijnens Johan , Husek Tomáš , Romero-López Fernando , Sharpe Stephen R. , Sjö Mattias 
Published: May 2023

Abstract
The three-particle K-matrix, $$ {\mathcal{K}}_{\textrm{df},3} $$

K

df
,
3

, is a scheme-dependent quantity that parametrizes short-range three-particle interactions in the relativistic-field-theory three-particle finite-volume formalism. In this work, we compute its value for systems of three pions at maximal isospin through next-to-leading order (NLO) in Chiral Perturbation Theory (ChPT). We compare the values to existing lattice QCD results and find that the agreement between lattice QCD data and ChPT in the first two coefficients of the threshold expansion of $$ {\mathcal{K}}_{\textrm{df},3} $$

K

df
,
3

is significantly improved with respect to leading order once NLO effects are incorporated.
Evaluation of miRNA-16–2-3P, miRNA-618 levels and their diagnostic and prognostic value in the regulation of immune response during SARS Cov-2 infection
Authors: Hassan Nourelhoda E. , Moselhy Walaa A. , Eldomany Ehab B. , Kholef Emad Farah Mohamad 
Published: May 2023

AbstractFollowing the announcement of the pandemic of COVID-19 in December 2019, several studies focused on how to early predict the severity of the disease in symptomatic and asymptomatic patients. Many cytokines including interleukin-6, interleukin-8, and tumor necrotic factors have been concluded as strong indicators for COVID-19 infection. Additionally, miRNAs have been associated with dysregulation in the immune system. The aim of this study are the following: (1) to estimate the level of miRNA-16–2-3P, miRNA-618, IL-8, IL-1β as predictors for SARS-CoV-2 complications in PCR negative and positive patients; (2) to assess the biological role and effect of these miRNAs on SARS-CoV-2 pathogenicity. Our study showed that the level of IL-1β had been significantly associated with patient who need hospitalization, also the alteration of the level of miRNA-16–2-3P, miRNA-618 is positively correlated with the admission of these patients and influence the outcomes of SARS-cov-2 infection. Measurement of miRNA-16–2-3P, miRNA-618, IL-1β could be a good predictor of COVID-19 patient outcome. However the measurement of IL-8 levels during immune responses in the admitted and in ICU patients could have a prognostic value.
Enhanced HPV16 E6/E7+ tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides
Authors: Stegmann Toon , Wiekmeijer Anna-Sophia , Kwappenberg Kitty , van Duikeren Suzanne , Bhoelan Farien , Bemelman Denzel , Beenakker Thomas J. M. , Krebber Willem-Jan , Arens Ramon , Melief Cornelis J. M. 
Published: May 2023

AbstractTherapeutic cancer vaccines trigger CD4 + and CD8 + T cell responses capable of established tumor eradication. Current platforms include DNA, mRNA and synthetic long peptide (SLP) vaccines, all aiming at robust T cell responses. SLPs linked to the Amplivant® adjuvant (Amplivant-SLP) have shown effective delivery to dendritic cells, resulting in improved immunogenicity in mice. We have now tested virosomes as a delivery vehicle for SLPs. Virosomes are nanoparticles made from influenza virus membranes and have been used as vaccines for a variety of antigens. Amplivant-SLP virosomes induced the expansion of more antigen-specific CD8 + T memory cells in ex vivo experiments with human PBMCs than Amplivant-SLP conjugates alone. The immune response could be further improved by including the adjuvants QS-21 and 3D-PHAD in the virosomal membrane. In these experiments, the SLPs were anchored in the membrane through the hydrophobic Amplivant adjuvant. In a therapeutic mouse model of HPV16 E6/E7+ cancer, mice were vaccinated with virosomes loaded with either Amplivant-conjugated SLPs or lipid-coupled SLPs. Vaccination with both types of virosomes significantly improved the control of tumor outgrowth, leading to elimination of the tumors in about half the animals for the best combinations of adjuvants and to their survival beyond 100 days.
Flatfoot over the centuries: the background of current conservative and operative treatments
Authors: Biz Carlo , Cerchiaro Mariachiara , Mori Fabiana , Rossin Alessandro , Ponticiello Mattia , Crimì Alberto , Ruggieri Pietro 
Published: May 2023

Abstract

Purpose

Although flatfoot is a widespread human condition, historical medical texts and ancient illustrations on this deformity are extremely rare. Nowadays, doubts regarding its management remain unsolved. This historical review aims to identify the presence of pes planus since the prehistoric era and examine the treatments proposed over the centuries up to the present.

Method
For this propose, we performed an extensive electronic search of the relevant literature, complemented by a manual search of additional sources from archaeological to artistic, literary, historical, and scientific accounts, describing flatfoot and its treatment in different eras.

Results
Flatfoot accompanied the evolutionary timeline of human species: from Lucy Australopithecus to Homo Sapiens. It was described among various diseases suffered by Tutankhamun (1343–1324 B.C.), while the first anatomical description dates to Emperor Trajan (53–117 A.D.) and the medical studies of Galen (129–201 A.D.). It was also represented in the anatomical drawings of Leonardo da Vinci (1452–1519) and Girolamo Fabrici d'Acquapendente (1533–1619). Historically, the conservative treatment by insoles was the only one proposed until the nineteenth century. Since then, the most popular surgical procedures performed for correction have been osteotomies, arthrodesis, arthrorisis, and tendon lengthening and transfer.

Conclusion
During the centuries, conservative therapeutic strategies have not radically changed in their substance, while operative ones have become the protagonists during the twentieth century up to the present. Nevertheless, after more than 2000 years of history, there is no consensus regarding the best indication for the flatfoot and if it really needs to be treated.
Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart
Authors: Smith Kelly A. , Dominado Nicole , Briffa Jessica F. 
Published: May 2023

AbstractTransmembrane protein 161b (Tmem161b) was recently identified in multiple high-through-put phenotypic screens, including in fly, zebrafish, and mouse. In zebrafish, Tmem161b was identified as an essential regulator of cardiac rhythm. In mouse, Tmem161b shows conserved function in regulating cardiac rhythm but has also been shown to impact cardiac morphology. Homozygous or heterozygous missense mutations have also recently been reported for TMEM161B in patients with structural brain malformations, although its significance in the human heart remains to be determined. Across the three model organisms studied to date (fly, fish, and mouse), Tmem161b loss of function is implicated in intracellular calcium ion handling, which may explain the diverse phenotypes observed. This review summarises the current knowledge of this conserved and functionally essential protein in the context of cardiac biology.
Performance analysis of gallium nitride-based DH-HEMT with polarization-graded AlGaN back-barrier layer
Authors: Kalita Sanjib , Awadhiya Bhaskar , Changmai Papul 
Published: May 2023

AbstractIn this paper, polarization-graded AlGaN back-barrier nanolayer has been introduced to improve the DC and RF parameters of gallium nitride-based high electron mobility transistors (HEMT). To explore the characteristics, both graded and non-graded double heterojunction high electron mobility transistor (DH-HEMT) structures are optimized using SILVACO-ATLAS physical simulator. Enhanced DC and RF parameters have been observed in the optimized graded DH-HEMT. In this paper, we have also studied the development of the quantum wells at the AlGaN/GaN interfaces due to the conduction band discontinuity in both structures.
Development and validation of a gene expression-based nomogram to predict the prognosis of patients with cholangiocarcinoma
Authors: Wang Wei , Wu Chen , Xu Lijun , Li Peilin , Wang Kai , Li Guangbing , Zhao Shanshan , Li Yongsheng , Fan Xiaoyu , Wang Weifeng , Hu Meizhen , Wu Jing , Xu Shifeng 
Published: May 2023

Abstract
Aim
To establish and validate a prognostic nomogram of cholangiocarcinoma (CCA) using independent clinicopathological and genetic mutation factors.

Methods
213 patients with CCA (training cohort n = 151, validation cohort n = 62) diagnosed from 2012 to 2018 were included from multi-centers. Deep sequencing targeting 450 cancer genes was performed. Independent prognostic factors were selected by univariate and multivariate Cox analyses. The clinicopathological factors combined with (A)/without (B) the gene risk were used to establish nomograms for predicting overall survival (OS). The discriminative ability and calibration of the nomograms were assessed using C-index values, integrated discrimination improvement (IDI), decision curve analysis (DCA), and calibration plots.

Results
The clinical baseline information and gene mutations in the training and validation cohorts were similar. SMAD4, BRCA2, KRAS, NF1, and TERT were found to be related with CCA prognosis. Patients were divided into low-, median-, and high-risk groups according to the gene mutation, the OS of which was 42.7 ± 2.7 ms (95% CI 37.5–48.0), 27.5 ± 2.1 ms (95% CI 23.3–31.7), and 19.8 ± 4.0 ms (95% CI 11.8–27.8) (p < 0.001), respectively. The systemic chemotherapy improved the OS in high and median risk groups, but not in the low-risk group. The C-indexes of the nomogram A and B were 0.779 (95% CI 0.693–0.865) and 0.725 (95% CI 0.619–0.831), p < 0.01, respectively. The IDI was 0.079. The DCA showed a good performance and the prognostic accuracy was validated in the external cohort.

Conclusion
Gene risk has the potential to guide treatment decision for patients at different risks. The nomogram combined with gene risk showed a better accuracy in predicting OS of CCA than not.
Awake craniotomy does not lead to increased psychological complaints
Authors: Wajer I. M. C. Huenges , Kal J. , Robe P. A. , van Zandvoort M. J. E. , Ruis C. 
Published: May 2023

Abstract

Background
Patients with brain tumours are increasingly treated by using the awake craniotomy technique. Some patients may experience anxiety when subjected to brain surgery while being fully conscious. However, there has been only limited research into the extent to which such surgeries actually result in anxiety or other psychological complaints. Previous research suggests that undergoing awake craniotomy surgery does not lead to psychological complaints, and that post-traumatic stress disorders (PTSD) are uncommon following this type of surgery. It must be noted, however, that many of these studies used small random samples.

Method
In the current study, 62 adult patients completed questionnaires to identify the degree to which they experienced anxiety, depressive and post-traumatic stress complaints following awake craniotomy using an awake-awake-awake procedure. All patients were cognitively monitored and received coaching by a clinical neuropsychologist during the surgery.

Results
In our sample, 21% of the patients reported pre-operative anxiety. Four weeks after surgery, 19% of the patients reported such complaints, and 24% of the patients reported anxiety complaints after 3 months. Depressive complaints were present in 17% (pre-operative), 15% (4 weeks post-operative) and 24% (3 months post-operative) of the patients. Although there were some intra-individual changes (improvement or deterioration) in the psychological complaints over time, on group-level postoperative levels of psychological complaints were not increased relative to the preoperative level of complaints. The severity of post-operative PTSD-related complaints were rarely suggestive of a PTSD. Moreover, these complaints were seldom attributed to the surgery itself, but appeared to be more related to the discovery of the tumour and the postoperative neuropathological diagnosis.

Conclusions
The results of the present study do not indicate that undergoing awake craniotomy is associated with increased psychological complaints. Nevertheless, psychological complaints may well exist as a result of other factors. Consequently, monitoring the patient’s mental wellbeing and offering psychological support where necessary remain important.
Changes in knee joint destruction patterns among patients with rheumatoid arthritis undergoing total knee arthroplasty in recent decades
Authors: Takeda Ryutaro , Matsumoto Takumi , Omata Yasunori , Inui Hiroshi , Taketomi Shuji , Nagase Yuichi , Nishikawa Takuji , Oka Hiroyuki , Tanaka Sakae 
Published: May 2023

Abstract
Objectives
This study aimed to investigate the trend of joint destruction patterns on knee radiographs of patients with rheumatoid arthritis (RA) undergoing total knee arthroplasty (TKA) over the past 16 years.

Method
Medial joint space, lateral joint space, medial spur area, lateral spur area (L-spur), and femoro-tibial angle were obtained from 831 preoperative knee radiographs of patients with RA who underwent TKA between 2006 and 2021 using software capable of automatic measurements. Non-hierarchical clustering was performed based on these five parameters. Trends in the five individual radiographic parameters and the ratio of each cluster were investigated during the target period. Moreover, clinical data from 244 cases were compared among clusters to identify factors associated with this trend.

Results
All parameters, except for L-spur, showed significant increasing trends from 2006 to 2021. The radiographs were clustered into groups according to the characteristic pattern of radiographic findings: cluster 1 (conventional RA type), with bicompartmental joint space narrowing (JSN), less spur formation, and valgus alignment; cluster 2 (osteoarthritis type), with medial JSN, medial osteophytes, and varus alignment; and cluster 3 (less destructive type), with mild bicompartmental JSN, less spur formation, and valgus alignment. The ratio of cluster 1 showed a significantly decreasing trend contrary to the significantly increasing trend in clusters 2 and 3. The DAS28-CRP of cluster 3 was higher than those of clusters 1 and 2.

Conclusions
Radiographs of TKA recipients with RA are increasingly presenting osteoarthritic features in recent decades.

Key Points• Using automated measurement software, morphological parameters were measured from radiographs of 831 patients with rheumatoid arthritis who had undergone TKA in the past 16 years.• Cluster analysis based on the radiographic parameters revealed that the radiographs of patients with end-stage knee arthritis requiring total knee arthroplasty were classified into three groups.• In patients with rheumatoid arthritis who have undergone total knee arthroplasty in the past 16 years, the proportion of clusters with features of osteoarthritis and difficult-to-treat rheumatoid arthritis has increased, while the proportion of conventional rheumatoid arthritis has decreased.
Cohomology of the discrete de Rham complex on domains of general topology
Authors: Di Pietro Daniele A. , Droniou Jérôme , Pitassi Silvano 
Published: May 2023

AbstractIn this work we prove that, for a general polyhedral domain of $$\mathbb {R}^3$$

R

3

, the cohomology spaces of the discrete de Rham complex of Di Pietro and Droniou (Found Comput Math 23:85–164, 2023, https://doi.org/10.1007/s10208-021-09542-8) are isomorphic to those of the continuous de Rham complex. This is, to the best of our knowledge, the first result of this kind for a fully computable arbitrary-order complex built from a general polyhedral mesh.
Amoral Management and the Normalisation of Deviance: The Case of Stafford Hospital
Authors: Entwistle Tom , Doering Heike 
Published: May 2023

AbstractInquiries into organisational scandals repeatedly attribute wrongdoing to the normalisation of deviance. From this perspective, the cause of harm lies not in the actions of any individual but rather in the institutionalised practices of organisations or sectors. Although an important corrective to dramatic tales of bad apples, the normalisation thesis underplays the role of management in the emergence of deviance. Drawing on literatures exploring ideas of amoral (Carroll in Bus Horiz 30(2):7–15, 1987) or ethically neutral leadership (Treviño et al. in Calif Manag Rev 42(4):128–142, 2000) we seek to bring management back into the explanation of organisational wrongdoing. Amoral theorists point to management’s ethical silence, but they also describe the way in which that silence is sustained by a series of organisational characteristics. We build on this work in arguing that it is management’s deliberate focus on bottom line performance, the diffusion of responsibility and high levels of organisational identification that explain the emergence of wrongdoing. We apply these ideas to the case of the UK’s Stafford hospital which hit the headlines in 2009 when it was reported that poor standards of care had led to a mortality rate markedly above that expected for a hospital of its type. We conclude with a discussion of the circumstances which translate amoral management into unethical outcomes.
The Enemy Hates Best? Toxicity in League of Legends and Its Content Moderation Implications
Authors: Aguerri Jesús C. , Santisteban Mario , Miró-Llinares Fernando 
Published: May 2023

AbstractIn recent decades, many sectors of our society have been digitized, and much of our life has moved to cyberspace, especially in terms of entertainment. Users meet, relate, and cooperate in the new public space that is the internet and form digital communities. Video games play a leading role in the formation of such communities. However, these communities also present antisocial behaviors, ranging from disruptive actions to harassment and hate speech. Such behaviors, encompassed under the umbrella term toxicity, are a major concern for both users and those in charge of moderating these spaces. This article focuses on toxicity in today’s leading online video game League of Legends. Three hundred twenty-eight matches were reviewed using a system of two judges to study the prevalence of these problematic behaviors. We find that 70% of matches were affected by disruptive behavior. Nevertheless, only 10.9% of the analyzed matches were exclusively affected by downright harmful behavior. In our view, the results have relevant implications for content moderation policy that are also addressed in this paper.