bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-10 Modulation Increases Pyrazinamide’s Antimycobacterial Efficacy against Mycobacterium tuberculosis Infection in Mice
Authors: Dwivedi Varun , Gautam Shalini , Beamer Gillian , Stromberg Paul C , Headley Colwyn A , Turner Joanne 
Published: June 2023

Abstract
Mechanisms to shorten the duration of tuberculosis (TB) treatment include new drug formulations or schedules and the development of host-directed therapies (HDTs) that better enable the host immune system to eliminate Mycobacterium tuberculosis. Previous studies have shown that pyrazinamide, a first-line antibiotic, can also modulate immune function, making it an attractive target for combinatorial HDT/antibiotic therapy, with the goal to accelerate clearance of M. tuberculosis. In this study, we assessed the value of anti–IL-10R1 as an HDT along with pyrazinamide and show that short-term anti–IL-10R1 blockade during pyrazinamide treatment enhanced the antimycobacterial efficacy of pyrazinamide, resulting in faster clearance of M. tuberculosis in mice. Furthermore, 45 d of pyrazinamide treatment in a functionally IL-10–deficient environment resulted in sterilizing clearance of M. tuberculosis. Our data suggest that short-term IL-10 blockade with standard TB drugs has the potential to improve clinical outcome by reducing the treatment duration.
FARG‘ONA MEZOLIT VA NEOLIT DAVRI JAMOALARINI O‘ZARO MADANIY ALOQALARI XUSUSIDA
Authors: Mirsoatova Sayyora , Muhsiddinov Ahrorbek 
Published: June 2023

Ushbu maqolada Farg‘ona vodiysining mezolit va neolit davri jamoalarining o‘zaro madaniy aloqalari, neolit davrida odamlarning o‘troq turmush tarziga o‘tishi va bu dehqon jamoalari o‘rtasida o‘zaro aloqalar rivojlanishiga imkon berishi Markaziy Farg‘ona madaniyatiga oid mezolit va neolit davri yodgorliklarini tadqiqotida qo‘shni Kaltaminor, Sazag‘on hamda Hisor jamoalari bilan o‘zaro madaniy aloqada bo‘lganliklari va boshqa bir qator masalalar yuzasidan so‘z yuritilgan.
АГРОКЛАСТЕРЛАР ВА УЛАРНИНГ РИВОЖЛАНИШИДА РАҚАМЛИ ТЕХНОЛОГИЯЛАРНИНГ ЎРНИ
Authors: Урдушев Хамракул , Мавлянов Мажид , Эшанкулов Сирожиддин , Розиева Гулхаё 
Published: June 2023

Бугунги кунда Ўзбекистонда иқтисодиётнинг барча соҳаларида рақамли технологиялардан фаол фойдаланилиш кузатилмоқда. Қишлоқ хўжалиги ҳам бундан мустасно эмас, давлат фаровонлигини оширишда рақамлаштириш асосий роллардан бирини ўйнайди. Ўзбекистон қишлоқ хўжалигида агрокластерлар тизими ва рақамли технологиялар жорий этилмоқда. Мақолада, қишлоқ хўжалигида рақамли технологияларни жорий этишнинг аҳамияти ёритилган. Рақамлаштиришда ривожланган хорижий давлатларда эришилган натижалар таҳлил қилинган. Қишлоқ хўжалиги корхоналари ишлаб чиқариш жараёнларини рақамли трансформация қилиш масалалари ёритилган.
ANALYSIS OF THE EFFECT OF DOWN TIME ON PRODUCTIVITY AT PT. EASTERN PEARL FLOUR MILLS MAKASSAR
Authors: Ahmad Ilham , Saleh Rahmawati , Rahmaniar Rahmaniar 
Published: June 2023

Productivity is a comparison between the results achieved (output) with the overall required resources (input) or a comparison between the results achieved with the role of labor per unit time.
The purpose of this study was to study Down Time analysis techniques for productivity in a wheat processing company (PT. Eastern Pearl Flour Mills Makassar), which produces wheat flour products of the Gatotkaca, Gunung, Kompas and Gerbang types. Down Time is the amount of time when a tool/machine cannot operate due to failure, but the factory can still operate because there are still other tools/machines that can replace functions so that the production process can still run.
Based on the data analysis of the calculation of down time for manpower, it shows that the existence of down time during the process will affect the level of productivity (actual and standard). The value of down time from the calculation of working hours minus work effectiveness results in down time for each production area each month. The manpower down time results from all areas, namely in the area of 0 minutes/month. While the amount of data from the analysis of down time calculations for machines in all areas has a higher number of machine down times, namely in the milling area of 28 hours. And for the lowest results, namely in the area of unloading, cleaning, and packing, it is 0 hours.
Gelenek, Tabu ve Şehirleşme Ekseninde Tokat Yöresi Sıraçları
Authors: KOÇAK Alirıza 
Published: June 2023

Türk kültürünün önemli parçalarından olan Alevilik Anadolu ve Balkan coğrafyalarında farklı kültürel topluluklar meydana getirmiştir. Tokat, bu inanç topluluğunun nüfus bakımından yoğun olduğu bir bölgedir. Zile’ye bağlı Acısu köyünde bulunan Anşa Bacı dergâhına intisap etmiş olan Sıraçlar Anadolu’da kadim Türk kültürünün izlerinin halen yakın zamana kadar canlı şekilde yaşatan bir topluluktur. Bu çalışma ile Sıraçların kapalı toplumsal yapıları dolayısıyla koruyarak yirminci yüzyıla kadar taşıdıkları kültürel niteliklerinin modern hayat şartları nedeniyle ne şekilde değiştiği ortaya konulacaktır.
Çalışma, Sigmung Freud tarafından Polenezya yerlilerinin toplumsal yaşamını tetkik etmek için kullanılmış olan tabu kavramı ve şehirleşmeye bağlı kültürel değişimler çerçevesinde Sıraçların geleneksel hayat tarzlarında meydana gelen değişimi evlilik ve ölüm ritüellerine dair uygulama ve inançlar bağlamında ele almaktadır.
Araştırma, bölgedeki Sıraç topluluğunun inanç merkezi olan Tokat ili Zile İlçesi Acısu köyü merkeze alınarak alan araştırmasıyla gerçekleştirilmiştir. Araştırmada otantik Sıraç kültürü halen köyde yaşayan Sıraç babaları ve köy halkından derlenirken modern hayatın geleneksel toplum yapısına etkileri konusunda şehrin kültürel habitatında yaşamakta olan Sıraçların görüşleri araştırmaya dahil edilmiştir.
Sonuç olarak Sıraçların kapalı toplum yapısı içerisinde yüzlerce yıl korudukları gelenek ve inanç unsurlarının kente göç ve dış dünya ile kurulan mecburi bağ neticesinde değişmeye ve bu kültürün otantik halini kaybetmeye başladığı tespit edilmiş; bu kültürün hangi unsurlarının tespit edilmesi gerektiğine dair değerlendirmeler yapılmıştır.
OCULAR CHANGES IN PREGNANT WOMEN
Authors: ATTYIA RASHID  , HUSSAIN AHMAD KHAQAN  , RUBINA YOUSAF  , QUNDEEL ZAHRA  , FARRUKH JAMEEL  
Published: June 2023

Objective: Pregnancy results in a lot of hormonal changes in the body and the eyes are no exception. These ocular changes could be physiologic, pathologic or a modification of a pre-existing condition. The aim of this study was to determine physiologic ocular changes that are associated with pregnancy in healthy women.
Materials and Methods: A total of 100 women were followed longitudinally through out the course of their pregnancy and 6 weeks postpartum. The women were recruited at 8 weeks of pregnancy at the anti-natal clinic in the Department of Obstetrics and Gynecology, Mansoorah Teaching Hospital,Lahore. The women were aged between 20 and 35 years. Tests carried out included visual acuity, ophthalmoscopy, retinoscopy, and tonometry. The tests were carried out in each of the three trimesters of pregnancy and 6 weeks postpartum.
Results: There was a fall in intraocular pressure across the trimesters and this was very significant (P<0.0001). Postpartum, the intraocular pressure began to rise. The difference between the third trimester and post-partum values was also statistically significant (P< 0.0001). The difference in visual acuity through out the pregnancy was not significant (P= 0.8477). Although, there was a fall in refractive error across the different trimesters, it was not statistically significant (P=0.3). There was also no difference in the third trimester and the 6 weeks postpartum values of both visual acuity and refractive error.
Conclusion: Ocular changes associated with pregnancy are transient and most tend to resolve postpartum, with values returning to near pre-pregnant state.
MALNUTRITION IS PREVALENT AMONG CHILDREN (2 MONTHS - 5 YEARS) SUFFERING FROM ACUTE RESPIRATORY TRACT INFECTIONS (ARI)
Authors: ABDUR REHMAN KHOKHAR  , M. SHAHID FARUQI  , ABDUL SATTAR  , Q. A. REHMAN  , KHAWAR IQBAL  
Published: June 2023

Background: Malnutrition is a worldwide problem and leading cause of childhood mortality and morbidity. Under nutrition in all its forms is still common is south East Asia.
Objective: To determine prevalence of malnutrition among children suffering from ARI and to find association between them.
Patients and Methods: This study was carried out at DHQ Hospital Dera Ghazi Khan from December 2008 to March 2009. Study population included children from OPD and indoor of Pediatric Department. It was a descriptive cross sectional study. Total of 350 ARI patients of age 2 months-5 years, 172 girls and 178 boys were enrolled. Responses to structured questionnaires were collected from all patients.
Results: Prevalence of malnutrition in age group 2 months-l year was 19%. There is increased incidence of malnutrition with increase of age. At 2 years age protein caloric malnutrition PCM was 12.5% among boys and 14% among girls. At age group 3, 4, 5, PCM was 13%, 20%, 27% respectively.
Conclusion: The prevalence of mal-nutrition was high at age group 1 year than 2 - 8 months, 2- 4 years while the PCM was observed as high as 25% at age group 5 years. ARI has significant relation with protein caloric Malnutrition.
TREND AMONG DOCTORS REGARDINGTHEIR OWN CERVICAL CANCER SCREENING
Authors: SADIA RIZWAN  , AMNA SHAHID  , NUZHAT KHAWAJA  
Published: June 2023

Background: Cervical cancer can be prevented, by regular screening by a test, called Pap smearand the most important risk factor for cervical cancer is “never having been screened”. Screening for cancer of the cervix remains a neglected health care issue in Pakistan.
Objective: To assess the practices/ trends and attitude about personal Pap smear among female doctors working in field of obstetrics and gynecology.
Study Design: Cross sectional descriptive study
Place of study: Obstetrics and Gynaecology Department, Lahore General Hospital Lahore.
Methodology: Five hundred lady doctors working in field of obstetrics and gynaecology were interviewed using a questionnaire. Data collected was analyzed by SPSS version 10.
Results: Only 3.60% of lady doctors ever had Pap smear and 1.40% had regular Pap smear.Mean age of respondents was 36 year. Only 08%were of parity more than five, mean age of marriage was 26 years and 1.4% were married twice. Oralcontraceptive pills user were 14.6%.The most common reasons of not having Pap smear were embarrassment (16%), busy schedule and considering that they do not have risk of cervical cancer (14 %)and lack of counseling / reminder (11.20%).
Conclusion: Female health professionals working in the field of obstetrics and gynaecology have negligible uptake of cervical cancer screening for their own selves despite being exposed to some of theimportant risk factors for carcinomacervix, which reflects their perception regarding importance of cervical cancer screening for women’s wellbeing. The results of this study may serve as a baseline for future comparisons. A larger community-based study may establish the exact trend, and will guide further planning in this regard.
Pemanfaatan Internet Sebagai Sumber Pembelajaran Di Sd Negeri Pondok Ranji 02
Authors: Ramadani Putri , Maknun Lu’luil 
Published: June 2023

Penelitian ini merupakan penelitian kualitatif deskriptif yang bertujuan untuk mengungkap terkait dengan pemanfaatan internet sebagai sumber pembelajaran, yang dilakukan di SD NEGERI PONDOK RANJI 02. Pengumpulan data dilakukan dengan mengadakan metode wawancara, observasi, dan dokumen. Hasil dari wawancara, observasi dan dokumen kemudian dianalisis dengan teknik deskriptif. Data dilakukan dengan menggunakan triangulasi data yaitu membandingkan data hasil observasi dengan data hasil wawancara dan dengan dokumen. Hasil penelitian tentang bagaimana Pemanfaatan internet sebagai sumber pembelajaran SD NEGERI PONDOK RANJI 02 , Bentuk pemanfaatan internet sebagai sumber pembelajaran SD NEGERI PONDOK RANJI 02 yang dilakukan oleh guru dan siswa adalah dengan penugasan oleh guru, siswa diberikan tugas untuk mencari, mempelajari, dan mengungkapkan pada saat pembelajaran untuk memperkaya keterbatasan materi yang ada pada buku dan lembar kerja anak yang digunakan pada saat pembelajaran dan untuk menjawab pertanyaan-pertanyaan yang muncul pada saat diskusi, keinginan anak yang tinggi untuk mencari pengetahuan dari berbagai sumber yang didapat melalui browsing dan searching di internet.
Penerapan Meteode Card Sort Untuk Meningkatkan Keaktifan Siswa Kelas V Pada Pelajaran Al-Qur’an Hadits
Authors: Alwan Muhammad 
Published: June 2023

Penelitian ini bertujuan untuk meningkatkan keaktifan siswa dalam proses pembelajaran.Penelitian ini dirancang dengan menggunakan Penelitian Tindakan Kelas. Instrumen penelitian yang dipakai dalam penelian ini adalah lembar observasi dan catatan lapangan digunakan untuk memperoleh data atauinformasi yang berkaitan dengan situasi kelas yang tidak tercantum dalam lembar observasi.Dalam penelitian ini catatan lapangan digunakan untuk mengamati hal-hal yang terjadi didalam kelas selam penerapan metode pembelajaran card sort. Hasil penelitian menunjukkanbahwa pada siklus I rata-rata keaktifan siswa sudah menunjukkan kategori tidak aktif dengan nilai 46,66% . Selanjutnya pada siklus II rata-rata keaktifan siswa sudah menunjukkan kategori cukup aktif dengan nilai 60%, akan tetapi pada siklus ini masih perlu dilakukan perbaikan sehingga peneliti menggunakan siklus III, Pada siklus III rata-rata keatifan siswa sudah menunjukkan angka 80% kategori aktif. Dengan demikian, metode pembelajaran Card Sort dapat direkomendasikan kepada guru dalam melaksanakan pembelajaran.
Análise dos resultados econômicos dos juizados especiais não-criminais do Tribunal de Justiça do Estado de Pernambuco no período de 2016 a 2020
Authors: Silva Antônio Alves da , Gomes Anailson Márcio 
Published: June 2023

Este estudo buscou elaborar e analisar as Demonstrações do Resultado Econômico (DRE) do Juizados Especiais Não-Criminais integrantes do Judiciário pernambucano no período de 2016 até 2020. Usou o modelo proposto por Slomski (1996) e a NBCT SP 16.11 do Conselho Federal de Contabilidade. O custo de oportunidade identificado para os órgãos analisados foi o custo do serviço prestado pela Justiça comum, sendo alternativa aplicável tendo em vista a atividade jurisdicional ser precípua de Estado. Nesse sentido foram comparadas as estruturas de custos dos Juizados supracitados com a estrutura de custos da instituição pernambucana. O cálculo dos custos da Justiça comum foi feito através da abordagem de custeio de absorção integral, onde se ajustou os valores de Variações Patrimoniais Diminutivas com as depreciações dos bens móveis calculadas. Observou-se que as informações geradas pela contabilidade atendem aos requisitos das normas contábeis aplicados ao Setor Público, restando apenas ajustar somando a depreciação de bens móveis às despesas reconhecidas nos períodos, usou-se as regras já definidas pela instituição para fins de cálculo da depreciação e composição do custo total dos serviços prestados. Foi identificado que apenas 25,30% dos Juizados apresentaram resultados econômicos negativos, não havendo padrão de concentração do ponto de vista geográfico (interior ou região metropolitana). Apresentam-se como limitações os critérios de rateio utilizados e os custos de manutenção de sistemas de informações que não foram possíveis atribuir. Sugere-se para pesquisas futuras a elaboração de DRE’s em outros órgãos do Poder Judiciário, para que se forme um panorama da realidade nacional.
Validitas Perangkat Pembelajaran Konsep Fluida Berbasis Science Technology Engineering Art Mathematic (STEAM) Berorientasi Education For Sustainable Development (ESD)
Authors: Widarti Rezki , Khoiri Nur , Roshayanti Fenny 
Published: June 2023

Tujuan penelitian ini ialah untuk memperoleh perangkat pembelajaran yang dapat diintegrasikan dengan STEAM berorientasi ESD pada materi fluida yang valid. Jenis penelitian ini adalah penelitian pengembangan (Research and Development) menggunakan model Borg and Gall yang disederhanakan menjadi tiga langkah yang terdiri atas pendahuluan, pengembangan, dan pengujian. Teknik pengumpulan data dengan memberikan angket validasi ahli dan praktisi pendidikan, dan dokumentasi. Teknik analisis data terdiri dari dua teknik, teknik pertama kuantitatif berupa hasil presentase validasi perangkat pembelajaran, dan teknik kedua adalah kualitatif yang berasal dari saran dan komentar validator. Hasil penelitian menunjukkan bahwa perangkat pembelajaran fisika berbasis STEAM berorientasi ESD memiliki hasil sangat valid. Hasil validasi ahli untuk silabus 93%, RPP 81%, e-modul 88% dan LKPD 78%. Hasil validasi praktisi pendidikan untuk silabus memiliki presentase 92%, RPP 94% E-modul 91% dan LKPD 91%.
Pengaruh Media Youtube Stand Up Comedy pada Pembelajaran Lawakan Tunggal terhadap Kemampuan Berbicara Kelas X SMKN 7 Semarang
Authors: Santika Mila , Ulumuddin Arisul , Kismiyati Sri 
Published: June 2023

Pada praktik lawakan tunggal yang dilakukan di depan kelas masih banyak siswa yang kebingungan dalam menyampaikan materi yang telah ditulis. Pada penampilan pertama peserta didik lebih banyak mengungkapkan secara monoton dan tidak terlihat bahwa materi yang disampaikan adalah bentuk humor. Peserta didik masih kebingungan untuk memulai kata, memberikan mimik muka yang sesuai dengan apa yang dikatakan sehingga siswa lain yang menonton tidak memahami maksud humor yang disampaikan. Tujuan dari eksperimen ini yaitu untuk mengetahui pengaruh dari pengaruh media YouTube Stand Up Comedy pada pembelajaran lawakan tunggal terhadap kemampuan berbicara kelas X SMKN 7 Semarang. Peneliti menggunakan metode eksperimen dengan melakukan uji normalitas dan uji T. Hasil nilai rata-rata pre-test yaitu 73,78 dan nilai rata-rata post-test yaitu 80,39. Hasil dari eksperimen menunjukkan tabel uji paired sample t-test diperoleh nilai signifikansi (2-tailed) yaitu 0,000 < 0,05. Dari hasil tersebut maka Hipotesis 0 ditolak dan Hipotesis a diterima. Simpulan dari hasil penelitian yaitu adanya pengaruh penggunaan media YouTube stand up comedy pada pembelajaran lawakan tunggal terhadap kemampuan berbicara kelas X SMKN 7 Semarang. Saran untuk penelitian selanjutnya untuk mengoptimalkan proses pengambilan data agar data yang diperoleh lebih valid.
Innovación y productividad en cadenas de suministro inteligentes en la postpandemia
Authors: Vázquez Valerio Gabriel Adrián 
Published: June 2023

La tendencia postpandemia orienta a MIPYMES a tecnología que impacta el funcionamiento de almacenes en operaciones de cadenas de suministro en México. El incremento del comercio electrónico mexicano ha exigido innovación en procesos logísticos de información gerencial siendo el eje rector del artículo, infiriendo este como un actor aditivo principal en los nuevos escenarios empresariales y al factor humano como creador principal de la ventaja competitiva incrementando valor a procedimientos que direccionen resultados y conduzcan estratégicamente cambios económicos globales y de salud mundial que infieren en la productividad de los negocios en el contexto digital logístico. En el artículo se utiliza una metodología cualitativa de corte descriptivo. Y cuantitativo de corte analítico. Se analiza una muestra representativa de empresas mexicanas utilizando escala Likert. Se examinan las variables de investigación determinando la objetividad que confluye en analizar tecnologías de información gerencial y el impacto de los microchips en la maximización de operaciones y concentración de información de las cadenas de suministro en la mediana y pequeña empresa de México comprendiendo el paradigma actual de postpandemia covid-19. El análisis compara los periodos 2021 y 2022 de actividad comercial en empresas mexicanas realizando una proyección para el 2023 del crecimiento tecnológico que incremente la productividad haciendo la simulación de operaciones del comercio electrónico que impulse el desarrollo en cadenas de suministro de pymes en México para lograr resultados.
Cooperación Propuesta del Sistema Integrado de Alimentación y Manejo para la Producción de Leche de forma Sostenible en la CPA Ofelio Caballero Peña
Authors: Cobas Villa Katia , Rodríguez Aguilera Yurisan , Cruz Prieto Elisabeth 
Published: June 2023

El presente trabajo, titulado Sistema Integrado de Alimentación y Manejo para la Producción de Leche en la CPA Ofelio Caballero Peña, socializa los resultados alcanzados en fue realizado para atenuar los problemas que inciden en la baja producción lechera. El diagnóstico de las limitantes se realizó a través de intercambios y asesoramientos, con el ánimo de buscar mejoras en este sentido en la organización. Para esto se tuvo en cuenta las características de los sistemas productivos, efectuándose el correspondiente análisis en cada lugar, incluyendo las instalaciones, la preparación de los colectivos, entre otros aspectos, se efectuaron las observaciones proporcionales a cada uno de los procesos productivos, la aplicación de nuevas tecnologías, lo acontecido en el cuidado del medio ambiente, en el ambiente de control y el desempeño de todos los factores políticos y administrativos; se tomaron en cuenta los indicadores de la eficiencia económica. Se concluye que con el suministro de plantas forrajeras y proteicas como El Kingrass, La Titónia, La Moringa, La Morera, y La Caña de Azúcar aparejado al Programa integral para la mejora de la producción y de la calidad de la leche. Con estas medidas se incrementan los volúmenes productivos, lo cual conlleva a un excelente nivel de sostenibilidad en la vaquería y por ende en la cooperativa.
Afectaciones de salud en estudiantes durante modalidad en línea derivado de la pandemia
Authors: Cortez Aguirre Claudia , Ferrer Gutiérrez Oscar , Laurencio Castillo Edmundo Jesús 
Published: June 2023

Con la llegada de la Pandemia de SARS-CoV-2 en 2019, diversos sectores se vieron en la necesidad de implementar estrategias que les permitiera continuar con sus actividades y ofreciendo sus servicios, el claro ejemplo se muestra en el sector educativo, que de manera obligada y como respuesta al reto de seguir brindando educación, trasladó las clases presenciales totalmente a distancia, lo que implicó que los estudiantes de los diferentes niveles educativos empezaran a utilizar diversas plataformas digitales e invirtieran tiempo en todo lo relacionado a esta forma de trabajo. Para llevar a cabo la educación en línea fue necesario el uso de dispositivos móviles o computadoras que facilitaron la conectividad de docentes y alumnos. Sin embargo, conllevó a un aumento del tiempo en que se permanece sentado, a adaptar espacios dentro del hogar para poder recibir las clases, así como al cambio de algunos hábitos poco saludables. Esta investigación se realiza para determinar las afectaciones de salud que los estudiantes presentan a raíz de la implementación de la modalidad en línea. La recolección de información fue mediante la aplicación de un cuestionario en línea a 209 estudiantes de nivel medio superior en el Plantel Cuauhtémoc de la Escuela Preparatoria de la Universidad Autónoma del Estado de México (UAEMéx), de los cuales 67.9% de sexo femenino y 32.1% masculino, en un rango de edad de 15 a 17 años.