bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross‐Cultural Differences in Patient Perceptions of Dyskinesia in Parkinson's Disease
Authors: Kaasinen Valtteri , Luo Sheng , Martinez‐Martin Pablo , Goetz Christopher G. , Stebbins Glenn T. 
Published: January 2023

ABSTRACTBackgroundThe prevalence of levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD) varies among geographical regions. Cultural differences in patient‐based perceptions of LID have not been studied.ObjectiveWe compared patient and clinician evaluations of LID severity across multiple cultures in patients with PD.MethodsThe data set included the Unified Dyskinesia Rating (UDysRS) scores from 16 language translation programs (3566 patients). We defined the Perception Severity Index (PSI) as the ratio between normalized patient‐based subjective ratings (UDysRS Part 1B) and normalized clinician examination (Parts 3 and 4) scores (Part 1B/Parts 3 + 4) and compared the PSI across languages.ResultsThe mean PSI for the Chinese language (2.16) was higher than those of all other languages, whereas the ratio for the Korean language (0.73) was lower than those for Japanese, German, Turkish, Greek, Polish, and Finnish languages (corrected P values <0.05).ConclusionsCulture, as represented by language, affects the subjective perception of LID and needs to be considered in multinational clinical PD trials on dyskinesia. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Analysis of ASS1 gene in ten unrelated middle eastern families with citrullinemia type 1 identifies rare and novel variants
Authors: Daou Melissa , Souaid Mirna , Yammine Tony , Khneisser Issam , Mansour Hicham , Salem Nabiha , Nemr Antony , Awwad Johnny , Moukarzel Adib , Farra Chantal 
Published: January 2023

AbstractBackgroundCitrullinemia type 1 (CTLN1) is a rare autosomal recessive disease caused by argininosuccinate synthetase (ASS) deficiency. Manifestations vary from the acute neonatal or “classic” form to a milder, late‐onset, or “unconventional” form. To date, more than 93 variants in the ASS1 gene located on chromosome 9q43.11 (OMIM #215700) are reportedly responsible for CTLN1. Their incidence and distribution vary according to geographic origins and ethnicity, and a correlation, although not clearly delineated, has been established between the genotype and the phenotype of the disease. Though, in the Middle East, national descriptions of CTLN1 are still lacking.MethodsA total of ten unrelated Middle Eastern families, five Lebanese, two Syrians, and three Iraqis with citrullinemia index cases, were included in this study. Upon informed consent, DNA was extracted from the whole blood of the index patients as well as their parents and siblings. Genetic analysis was carried out by Sanger sequencing of the ASS1 gene.ResultsSeven different variants were identified. Two novel variants, c.286C>A (p.(Pro96Thr), RNA not analyzed) in exon 5 and deletion c.685_688+6del(p.(Lys229Glyfs*4), RNA not analyzed) in exon 10, were found in one Lebanese and one Syrian family, respectively, and were correlated with early‐onset and severe clinical presentation. Five other known variants: c.535T>C (p.(Trp179Arg), RNA not analyzed) in exon 8, c.787G>A (p.(Val263Met), RNA not analyzed) in exon 12, c.847G>A (p.(Glu283Lys), RNA not analyzed) in exon 13, c.910C>T (p.(Arg304Trp), RNA not analyzed) in exon 13, and c.1168G>A (p.(Gly390Arg), RNA not analyzed) in exon 15, were found in Lebanese, Syrian, and Iraqi families, and were associated with diverse clinical presentations.ConclusionTwo novel variants and five known variants were found in a total of ten unrelated Middle Eastern families.
Clinical and genetic findings in Chinese families with congenital ectopia lentis
Authors: Liu Xin , Niu Liman , Zhang Liyun , Jiang Liqiong , Liu Kaiqing , Wu Xueping , Liu Xinhua , Wang Jiantao 
Published: January 2023

AbstractBackgroundCongenital ectopia lentis (EL) refers to the congenital dysplasia or weakness of the lens suspensory ligament, resulting in an abnormal position of the crystalline lens, which can appear as isolated EL or as an ocular manifestation of a syndrome, such as the Marfan syndrome. The fibrillin‐1 protein encoded by the FBN1 gene is an essential component of the lens zonules. Mutations in FBN1 are the leading causes of congenital EL and Marfan syndrome. Owing to the complexity and individual heterogeneity of FBN1 gene mutations, the correlation between FBN1 mutation characteristics and various clinical phenotypes remains unclear.MethodsThis study describes the clinical characteristics and identifies possible causative genes in eight families with Marfan syndrome or isolated EL using Sanger and whole‐exome sequencing.ResultsEight FBN1 mutations were identified in these families, of which three (c.5065G > C, c.1600 T > A, and c.2210G > C) are reported for the first time. Based on in silico analyses, we hypothesized that these mutations may be pathogenic by affecting the fibrillin‐1 protein structure and function.ConclusionThese findings expand the number of known mutations involved in EL and provide a reference for the research on their genotype and phenotype associations.
Depression symptoms and core affect: Results from network and regression analyses
Authors: Vanags Edmunds , Raščevska Malgožata 
Published: January 2023

AbstractDepression is measured in most studies by surveys that sum individual symptom scores into one common variable. Given the high heterogeneity of depressive disorders and the diversity of symptom profiles at the same levels of depression, a significant amount of information is, therefore, not evaluated. In this study, we aimed to investigate how distinct depression symptoms from the tripartite model of anxiety and depression relate to the dimensions of core affect. The study included N = 1102 individuals who completed depression, anxiety and stress, and core affect scales. Participants were recruited from the convenience sample and were aged between 18 and 59 years (M = 39.70; SD = 12.03) with 38.2% men and 61.8% women, whose average number of years spent in education was M = 14.17; SD = 3.63. Correlation and regression analysis with JASP and R software showed that all depressive symptoms were significantly related to the core affect dimensions (valence and activation), and network analysis indicated which symptoms formed undirected interrelationships and what their possible roles were in the model. We concluded that not all depression symptoms in the network model formed similar relationships with the dimensions of core affect, which may be explained through both validity and nonclinical sampling aspects.
Technical note: Extended longitudinal and lateral 3D imaging with a continuous dual‐isocenter CBCT scan
Authors: Reynolds Tess , Hatamikia Sepideh , Ma Yiqun Q. , Dillon Owen , Gang Grace , Stayman J. Webster , O'Brien Ricky 
Published: January 2023

AbstractBackgroundThe clinical benefits of intraoperative cone beam CT (CBCT) during orthopedic procedures include (1) improved accuracy for procedures involving the placement of hardware and (2) providing immediate surgical verification.PurposeOrthopedic interventions often involve long and wide anatomical sites (e.g., lower extremities). Therefore, in order to ensure that the clinical benefits are available to all orthopedic procedures, we investigate the feasibility of a novel imaging trajectory to simultaneously expand the CBCT field‐of‐view longitudinally and laterally.MethodsA continuous dual‐isocenter imaging trajectory was implemented on a clinical robotic CBCT system using additional real‐time control hardware. The trajectory consisted of 200° circular arcs separated by alternating lateral and longitudinal table translations. Due to hardware constraints, the direction of rotation (clockwise/anticlockwise) and lateral table translation (left/right) was reversed every 400°. X‐ray projections were continuously acquired at 15 frames/s throughout all movements. A whole‐body phantom was used to verify the trajectory. As comparator, a series of conventional large volume acquisitions were stitched together. Image quality was quantified using Root Mean Square Deviation (RMSD), Mean Absolute Percentage Deviation (MAPD), Structural Similarity Index Metric (SSIM) and Contrast‐to‐Noise Ratio (CNR).ResultsThe imaging volume produced by the continuous dual‐isocenter trajectory had dimensions of L = 95 cm × W = 45 cm × H = 45 cm. This enabled the hips to the feet of the whole‐body phantom to be captured in approximately half the imaging dose and acquisition time of the 11 stitched conventional acquisitions required to match the longitudinal and lateral imaging dimensions. Compared to the stitched conventional images, the continuous dual‐isocenter acquisition had RMSD of 4.84, MAPD of 6.58% and SSIM of 0.99. The CNR of the continuous dual‐isocenter and stitched conventional acquisitions were 1.998 and 1.999, respectively.ConclusionExtended longitudinal and lateral intraoperative volumetric imaging is feasible on clinical robotic CBCT systems.
Prone position, time to reach nutrition target, and energy/protein achievement rate on the seventh day of intensive care unit stay in patients with COVID‐19: A cohort study
Authors: Richrot Thamy Schossler , Lima Júlia , Stello Bruna Barbosa , Milanez Danielle Silla Jobim , Burgel Camila Ferri , Silva Flávia Moraes 
Published: January 2023

AbstractBackgroundWe aimed to evaluate the mean time to reach the energy (EAR) and protein (PAR) achievement rate among patients with coronavirus disease 2019 (COVID‐19) who did or did not undergo prone position (PP) therapy in the first week of their stay in the intensive care unit (ICU), and the interaction of these nutrition therapy indicators on the association between PP and clinical outcomes.MethodsThis cohort study used retrospective data collected from medical records of patients with COVID‐19 admitted to the ICU (≥18 years). We collected nutrition data, clinical information, prescription of PP, and its frequency during the first week, and clinical outcomes.ResultsPP therapy was administered to 75.2% of 153 patients (61.5 ± 14.8 years, 57.6% males) during the first week of their ICU stay. Patients who underwent PP reached nutrition therapy goals later (4 [3–6] vs 3 [2–4] days; P = 0.030) and had lower EAR (91.9 ± 25.7 vs 101.6 ± 84.0; P = 0.002) and PAR (88.0 ± 27.7 vs 98.1 ± 13.5; P = 0.009) in comparison to those who did not receive PP. Grouping patients who underwent PP according to the EAR (≥70% or <70%) did not show any differences in the incidence of ICU death, duration of mechanical ventilation, or ICU stay (P > 0.05).ConclusionsIn this exploratory study, PP was associated with a delayed time to reach the nutrition target and the lowest EAR and estimated protein requirement on the seventh day of ICU stay in patients with COVID‐19. Permissive enteral nutrition prescription in patients who underwent PP was not associated with worse clinical outcomes.
Optimal control and stabilization for discrete‐time networked control systems with multichannel Markovian packet losses
Authors: Han Chunyan , Zhang Song , Wang Wei , Shen Tao 
Published: January 2023

AbstractThis article is concerned with the optimal control and stabilization for the discrete‐time networked control systems with Markovian fading channels in a diagonal form, which indicates that different channel possesses different correlated fading property. To overcome the essential difficulty resulting from the multi communication channel packet losses and the correlation of the Markov chain, a new multistate Markov chain is introduced, by which the optimal control and stabilization for the NCSs with the diagonal form of Markovian fading channels are transformed into the ones for the general Markovian jump linear system. According to the converted system, a new modified maximum principle is presented, that is, a forward‐backward stochastic difference equation (FBSDE) is obtained. In the finite horizon design, the key step is to seek for the relationship between the system state and optimal costate. By the obtained relation and based on a new coupled difference Riccati equation (CDRE), a necessary and sufficient solvability condition for the optimal control is obtained as well as an explicit expression for the optimal controller. For the infinite horizon case, a new type of coupled Lyapunov function is defined, which keeps consistent with the finite horizon optimal performance index. By introducing a new coupled algebraic Riccati equation and using the defined Lyapunov function, a necessary and sufficient stabilization condition in the mean‐square sense and an infinite horizon optimal controller are presented. Finally, a numerical example is supplied to illustrate the efficiency of the proposed results.
Comparison of bioresorbable bone substitutes, carbonate apatite and β‐tricalcium phosphate, for alveolar bone augmentation with simultaneous implant placement
Authors: Fukuda Naoyuki , Kudoh Keiko , Akita Kazuya , Takamaru Natsumi , Ishikawa Kunio , Miyamoto Youji 
Published: January 2023

AbstractAimThis study histologically compared two bioresorbable bone substitutes with different composition, carbonate apatite (CO3Ap) and beta‐tricalcium phosphate (β‐TCP), through alveolar bone augmentation with simultaneous titanium implant placement in beagle dogs.MethodsBone defects (length 7 mm, width 2 mm, and depth 6 mm) were created bilaterally at mandibular premolar sites and augmented with either CO3Ap or β‐TCP granules after titanium implant installation. The specimens with the surrounding tissue were harvested from the mandible at 4, 12, and 24 weeks postoperatively, and histological evaluation was performed.ResultsMost β‐TCP granules dissolved in early stages postoperatively, resulting in a lower volume of alveolar bone surrounding the titanium implant. By contrast, in the case of CO3Ap group, the alveolar ridge was reconstructed without reducing the alveolar bone height, and almost all implant threads were covered with new bone by at least 12 weeks postoperatively. Quantitatively, the CO3Ap group showed a significantly higher percentage of new bone formation in the alveolar ridge portion at all follow‐ups. Additionally, it demonstrated a significantly higher bone‐to‐implant contact ratio than that of the β‐TCP group at 12 and 24 weeks after implantation (70.8 ± 5.6% vs. 29.3 ± 16.4% and 54.8 ± 6.9% vs. 41.8 ± 2.2%, respectively).ConclusionIn conclusion, based on the superior outcomes noted in this study, CO3Ap is useful for clinical use in alveolar bone augmentation with simultaneous implant placement.
Transforming freshwater politics through metaphors: Struggles over ecosystem health, legal personhood, and invasive species in Aotearoa New Zealand
Authors: Tadaki Marc , Clapcott Joanne , Holmes Robin , MacNeil Calum , Young Roger 
Published: January 2023

AbstractMetaphor, defined as the linguistic substitution of one phenomenon for another, is ubiquitous in environmental science and policy. In science, when used well, metaphors help to make complex and abstract ideas familiar and relatable, while also helping people orient ethically to the natural world. In freshwater science, metaphors structure many aspects of scientific and lay understanding.Yet, while metaphors are often used in environmental science and advocacy, there is a need to join up our currently diffuse understandings about how metaphors can help achieve social transformation for sustainability. Here, we focus on how metaphors are enshrined into institutions, giving them permanence and force as tools for social transformation.We explore three examples of metaphors in environmental science and activism that have ‘gone public’ to shape freshwater politics and governance in Aotearoa New Zealand (henceforth Aotearoa NZ). We focus on the origins, strategic purposes and limitations of the metaphors, the ways they have been institutionalised, and the roles that scientists in particular have played in shaping metaphorical meanings.Metaphors perform diverse political tasks, from mobilising popular support for species removal, to reorienting human obligations to rivers, through to expanding the scope of vision for river management. Scientists play key roles in shaping both regulatory institutions as well as informal norms that affect metaphor implementation. Finally, what makes a ‘good’ metaphor needs to be evaluated in context of who is mobilising the metaphor and what their broader sustainability values and objectives are.Read the freePlain Language Summaryfor this article on the Journal blog.
A novel smart stealth sorafenib delivery system based on the magnetic imprinting material modified by polyethylene glycol
Authors: Wang Duoduo , Bao Yuqi , Tan Yaxin , Liu Lijie , Ye Qiaorong , Zeng Chensi , Tan Ni 
Published: January 2023

AbstractIn order to improve the solubility and the long‐cycle performance of hydrophobic drug sorafenib (SOR), and to obtain an ideal smart drug delivery system for the effective treatment of liver cancer, S‐SMIP, a pH/GSH double‐sensitive sorafenib stealth imprinting material, was successfully prepared by UV‐initiated surface imprinted polymerization on the basis of polyethylene glycol 2000 (PEG2000) acted as “gate keeper” modified magnetic substrate. The results showed that S‐SMIP had a good adsorption capacity of 260.0 mg g−1 and an excellent selectivity factor α 2.33. S‐SMIP's kinetic adsorption data accorded well with the pseudo‐second‐order model and its mechanism was controlled mainly by chemical adsorption. The drug release experiments in vitro indicated S‐SMIP could not only greatly improve the solubility of SOR, but also had the pH/GSH dual‐sensitive response performance. Compared with the non‐stealth imprinted material SMIP, S‐SMIP still had a better long‐cycle effect on the release of SOR, increasing to160 h from 130 h. So, the target material S‐SMIP could greatly prolong the half‐life of SOR, which provided a good idea for the development of a smart drug delivery system.
An evaluation of a decision‐making model on preservice teachers' instructional decision‐making from curriculum‐based measurement progress monitoring graphs
Authors: LaLonde Kate , VanDerwall Rena , Truckenmiller Adrea J. , Walsh Meagan 
Published: January 2023

AbstractThe current study used a randomized control trial to evaluate a decision‐making model on special education preservice candidates' instructional decision‐making and self‐reported confidence ratings when analyzing graphed student data. Thirty‐two special education preservice candidates viewed authentic curriculum‐based measurement (CBM) graphs and selected an instructional decision based on the data. Half of the participants received a decision‐making model (i.e., flowchart) to guide instructional decision‐making and all participants were asked to rate their level of confidence analyzing graphs pre‐ and poststudy. Statistically significant and large differences in the accuracy of instructional decisions and confidence ratings were observed for the participants who used the decision‐making model relative to the control group. The results of the study suggest that a simple, cost‐effective intervention that does not require training from an expert can have a positive impact on teachers' data‐based decision‐making.
Associations between physical health and the alternative model of personality disorders: A cross‐sectional age study
Authors: Stone Lisa E. , Segal Daniel L. 
Published: January 2023

AbstractThe Alternative Model of Personality Disorders (AMPD) is a relatively new dimensional model of personality disorders (PDs) that assesses two diagnostic constructs: personality functioning and pathological personality traits. Thus far, research on the AMPD among older adults has been limited, but the research that does exist suggests limited generalizability to the unique biopsychosocial context of later life. To further examine the applicability of the AMPD to older adults, the purpose of this study was to examine relationships between the AMPD's two constructs with perceived physical health status among younger and older adult samples. Older adults (n = 222) and younger adults (n = 215) completed the Short Form‐36 (SF‐36), Levels of Personality Functioning Scale‐Self‐Report (LPFS‐SR), and Personality Inventory for DSM‐5‐Brief Form (PID‐5‐BF). Correlations and Fisher's z‐tests revealed significantly stronger relationships between the SF‐36 with the LPFS‐SR and PID‐5‐BF domains for older adults than younger adults. Additionally, age group significantly moderated the relationships between personality functioning and pathological personality traits and health. The stronger relationships between health and the AMPD's constructs for older adults suggest meaningful overlap between negative health outcomes and PD pathology. Future research should further investigate specific mechanisms in which personality pathology negatively impacts health in older adults.
Porous polycarbazole materials prepared by ionothermal synthesis method for carbon dioxide adsorption and electrochemical capacitors
Authors: Tao You , Wang Tian‐Xiong , Ding Xuesong , Han Bao‐Hang 
Published: January 2023

AbstractThe scopes of synthesis methods of porous polycarbazole materials are still under continuous developments because the polycarbazole materials with high stability and excellent porosity are suitable for various advanced applications. Here, ionothermal synthesis method for preparing porous polycarbazole materials is reported for the first time, by which a series of polycarbazole materials with good porosity and high yield are synthesized. Thereinto, the ferric chloride plays the roles of catalyst and molten solvent for preparing porous polycarbazole materials. The transformation of the pore structure due to slight carbonization during the process of ionothermal synthesis shows profound impacts on application performances. As intercomparison among these polymers, some porous polycarbazole materials with the predominant micropores possess a good performance of carbon dioxide uptake, others with micro‐mesopore structures show a high capacity of electrochemical energy storage. This simple and practicable method provides a pathway for synthesizing novel porous polycarbazole materials and similar porous organic polymers.