bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of defatted coconut flour on functional, nutritional, textural and sensory attributes of rice noodles
Authors: Sundaresan Thirumal , Subramaniam Sanjay , Chinnapa Veeramani , Rajoo Baskar 
Published: July 2023

SummaryDefatted coconut flour (DCF) obtained after the coconut oil extraction was incorporated at different concentrations (0%, 10%, 20%, 30%, 40% and 50%) in rice noodles to increase the fibre and protein content. The functional characteristics of the flour blends and nutritional composition, colour, cooking qualities, textural, antioxidant properties, shelf life and sensory qualities of the noodles were assessed. The incorporation of DCF significantly (P < 0.05) increased Water Solubility Index (WSI), water absorption capacity (WAC) and oil absorption capacity (OAC). In contrast, properties like bulk density, foaming capacity (FC), emulsion activity and viscosity decreased significantly (P < 0.05). Nutrition analysis revealed that DCF‐enriched formulations had significantly more crude fibre, protein, antioxidant, polyphenol, flavonoid and mineral content than the control sample. Furthermore, the incorporation of DCF significantly (P < 0.05) increased swelling volume (2.33 ± 0.06% to 5.65 ± 0.21%), water uptake ratio (108.91 ± 0.03% to 191.21 ± 0.04%), cooking loss (4.61 ± 0.04% to 7.83 ± 0.02%), cooking time (2.62 ± 0.05 to 4.14 ± 0.04 min) and noodle thickness (0.21 to 0.27 cm). When DCF was added to noodles, the ΔE values were significantly (P < 0.05) increased, but the hardness, springiness, cohesiveness, chewiness, resilience, gumminess, L*, hue and chroma were significantly (P < 0.05) decreased. Higher sensory scores were observed when DCF was incorporated up to 10%. The shelf life of the optimised noodles (with 10% DCF) was also assessed. The optimised noodle samples have a shelf life of 351 days at 29 °C. In conclusion, noodles made with DCF had more protein and fibre than those made with rice flour.
Impact of replacing sugar withStevia rebaudianaBertoni leaves on the physical–chemical and sensory characteristics of gluten‐free and lactose‐free cake
Authors: de Souza Nespeca Lucas , Cardoso Flávia Aparecida Reitz , Droval Adriana Aparecida , Marques Leila Larisa Medeiros , Beneti Stéphani Caroline , Heck Stênio Cristaldo , Fuchs Renata Hernandez Barros 
Published: July 2023

SummaryThis study evaluated the influence of replacing sugar withStevia rebaudianaleaves on gluten‐ and lactose‐free cakes' sensory and physicochemical characteristics. The cakes underwent microbiological analysis, texture profile, specific volume, acceptance test and purchase intention, as well as the rate‐all‐that‐apply (RATA) descriptive test. With the results of the acceptance test and texture profile, the desirability function was applied in order to obtain an optimised formulation (FO) with lower values for hardness and chewiness and higher values for overall acceptance. As the stevia content in the cakes increased, the acceptability of these attributes decreased, and the same occurred with purchase intention. In the texture profile, only hardness, chewiness, gumminess and specific volume showed significant differences, influenced by the sugar content, since this component adds positively to the dough and texture of the cakes. Applying the desirability function, the optimised formulation presented a composition of 65% (1.95 g) of stevia and 35% (35 g) of sugar, and new analyses were performed, with a global acceptance of 7.20, for example. It was concluded that it was possible to make gluten‐free and lactose‐free cakes by applying stevia leaves. However, this addition should be done moderately since it is inversely proportional to the acceptability of the attributes.
Effect of UV‐B irradiation on bioconversion of ergosterol to vitamin D2 and its impact on nutritional properties of oyster mushroom (Pleurotus florida)
Authors: Kaur Manpreet , Sharma Shivani , Kaur Ravneet , Kaur Jaspreet , Singh Arashdeep 
Published: July 2023

SummaryVitamin D deficiency is a global concern for vegetarians as most of the vitamin D‐enriched foods are of animal origin. Pleurotus florida is an excellent source of ergosterol, which gets converted into vitamin D2 under UV exposure. The objective of this study was to optimise UV‐B intensity (1.00–2.50 W/cm2) and exposure time (20–120 min) for maximum ergosterol conversion to vitamin D2. The optimisation studies indicated that exposure with intensity (2.00 W/cm2) for 60 min showed maximum vitamin D formation. The analysis of different nutritional parameters revealed no significant impact on total soluble proteins while a significant increase in total phenolic and total flavonoid contents was observed. On the contrary, a significant reduction was observed in riboflavin content of P. florida. Overall, P. florida exposure to UV‐B is a sustainable approach to enhance the vitamin D content for the development of fortified mushroom products or dietary supplements.
CD4 T cells and toxicity from immune checkpoint blockade
Authors: Earland Noah , Zhang Wubing , Usmani Abul , Nene Aishwarya , Bacchiocchi Antonella , Chen David Y. , Sznol Mario , Halaban Ruth , Chaudhuri Aadel A. , Newman Aaron M. 
Published: July 2023

SummaryImmune‐related toxicities, otherwise known as immune‐related adverse events (irAEs), occur in a substantial fraction of cancer patients treated with immune checkpoint inhibitors (ICIs). Ranging from asymptomatic to life‐threatening, ICI‐induced irAEs can result in hospital admission, high‐dose corticosteroid treatment, ICI discontinuation, and in some cases, death. A deeper understanding of the factors underpinning severe irAE development will be essential for improved irAE prediction and prevention, toward maximizing the benefits and safety profiles of ICIs. In recent work, we applied mass cytometry, single‐cell RNA sequencing, single‐cell V(D)J sequencing, bulk RNA sequencing, and bulk T‐cell receptor (TCR) sequencing to identify pretreatment determinants of severe irAE development in patients with advanced melanoma. Across 71 patients separated into three cohorts, we found that two baseline features in circulation—elevated activated CD4 effector memory T‐cell abundance and TCR diversity—are associated with severe irAE development, independent of the affected organ system within 3 months of ICI treatment initiation. Here, we provide an extended perspective on this work, synthesize and discuss related literature, and summarize practical considerations for clinical translation. Collectively, these findings lay a foundation for data‐driven and mechanistic insights into irAE development, with the potential to reduce ICI morbidity and mortality in the future.
Zirconia/garnet multiphase ceramics with high immobilization capacity for Nd confers better physical and chemical stability
Authors: Ge Yong , Xu Baoliang , Liao Yiliao , Zhang Xueyu , Yan Xu , Zheng Caohui , Duan Tao 
Published: July 2023

AbstractMultiphase ceramics have a high application potential in the field of nuclear waste immobilization because of the efficient synergy between the individual phases. In this work, zirconia/garnet multiphase ceramics with high efficient and effective immobilization capacity of trivalent actinides were successfully prepared using conventional solid‐phase sintering. ZrO2 doping increases the lattice site available for nuclide substitution and advance the immobilization capacity of the ceramic substrate for nuclide. At the same time, the phase change of zirconia is used to tougher and improve the physical properties of the ceramic waste form. The feasibility of using multiphase ceramics for the efficient immobilization of trivalent actinides was assessed by studying the phase evolution, microstructure, Vickers hardness, and chemical stability of the multi‐phase ceramics. Zr1‐xNdxO2‐x/2/Ca3‐yNdyZr3‐yFey‐1Fe3O12 multiphase ceramics exhibited superior physical or chemical properties compared to most of the multiphase ceramics as well as the previously prepared single‐phase calcium garnet ceramic waste forms. The Vickers hardness of all the multiphase ceramic samples ranged between 685 and 730 HV0.5. Under the condition of using simulate Bei Shan groundwater as leaching agent, the normalized leaching rates of Nd is approximately 10−6 g·m−2·day−1, showing good chemical stability and achieving efficient and effective immobilization of trivalent actinides. The excellent chemical, as well as physical properties of Zr1‐xNdxO2‐x/2/Ca3‐yNdyZr3‐yFey‐1Fe3O12 multiphase ceramics are expected to make them one of the substrates for more efficient and effective immobilizing of trivalent actinides.
Rapid fabrication of Si3N4 ceramics with gradient appearance and microstructure
Authors: Du Songmo , Zhang Jie , Li Fei , Chen Zhanglin , Zhang Shijia , Zhao Shuo , Cui Wei , Chen Kexin , Liu Guanghua 
Published: July 2023

AbstractSi3N4 ceramics with tailored gradient in color and microstructure were prepared by a rapid cost‐effective one‐step approach. The gradient microstructure was obtained by the manipulation of the dissolution‐reprecipitation process, by controlling the sintering temperature and sintering additive content. In the Si3N4 ceramics, the β‐phase content gradually changed from 84% to 11%. The Si3N4 ceramics exhibited white color on one side and showed a hardness of 19 GPa and fracture toughness of 7 MPa·m1/2 and may be suitable for bio‐implantation applications.
Colored Si3N4 ceramics via constructing Nd3+ doped core‐shell structures
Authors: Liu Ning , Hu Tengfei , Zhang Jingxian , Yusen Duan , Wang Zhen , Dong Shaoming 
Published: July 2023

AbstractSi3N4 ceramics have been attractive casing materials for electronics devices under the 5th generation mobile communication technology because of its outstanding comprehensive properties. However, single color cannot meet the needs of most consumers. Here, a typical strategy, involving forming core‐shell structures by utilizing Nd2O3‐MgO‐YAG system, is proposed to rich color. Scanning transmission electron microscope‐energy dispersive X‐ray spectrometry results confirm the presence of core‐shell structures in the silicon nitride matrix, and the core is pore and the shell is Nd‐enriched liquid phase. The Nd‐rich core‐shell structure as the color center makes the silicon nitride appear cyan or blue.
Basic Human Values and Preferences for an EU‐Wide Social Benefit Scheme
Authors: Reinl Ann‐Kathrin , Seddig Daniel , Dennison James , Davidov Eldad 
Published: July 2023

AbstractPrevious explanations regarding transnational solidarity in the European Union (EU) have mainly focussed on factors including left–right self‐placement, support for European integration and European identity. We expand this model by considering deeper psychological determinants of transnational solidarity: values, operationalised as Schwartz's basic human values of universalism and security. We expect them to exert (1) direct effects on transnational solidarity – measured as support for pan‐European social benefits – and (2) indirect effects via the three aforementioned factors. We test and find evidence to support our theoretical framework using multigroup structural equation modelling and data from the European Social Survey. We further show that the effect size of the value of universalism on preferences for an EU social benefit scheme in each country is positively moderated by that country's net contribution to the EU budget, highlighting the interaction between material interests and psychological value motivations.
Response to uncertainty in developmental origins of health and disease research: commentary on Nomura et al. (2022)
Authors: Nomura Yoko , Newcorn Jeffrey H. , Hurd Yasmin L. 
Published: July 2023

We appreciate the comments of Gilman et al. (2023) on our paper and their acknowledgement of its importance in highlighting the significance of this area of research. Further, their acknowledgment that the primary results of our study are in a range that is similar to those from other published studies of children exposed to highly stressful environmental events emphasizes the validity of our findings and the important extension of our results to children experiencing these events in utero. They, however, raised concerns about some of the results regarding specific types of psychiatric disorders and sex‐specific results related to the prenatal Superstorm Sandy hurricane exposure. We comment on the various issues related to the paper below but will not respond to comments regarding the press coverage of this article, which we think are beyond the scope of this commentary.
Insights into varroa mite (Varroa destructor) infestation levels in local honeybee (Apis mellifera) colonies of Ethiopia
Authors: Gela Alemayehu , Atickem Anagaw , Bezabeh Amssalu , Woldehawariat Yitbarek , Gebresilassie Araya 
Published: July 2023

AbstractThe varroa mite (Varroa destructor) is the most economically important parasitic pest of honey bees (Apis mellifera) that causes global colony decline and loss. Since its first detection in Ethiopia in 2010, little is known about the current infestation levels and contributing factors to the mite's distribution across the country. In this study, we conducted a large‐scale assessment of varroa prevalence and infestation levels in managed colonies across three potential beekeeping regions of Ethiopia; Oromia, Amhara and Southern Nations, Nationalities and Peoples Region (SNNPR). A total of 360 samples from 39 apiaries were collected following standard protocols and the mite prevalence and infestation levels were determined using the established method of varroa research. Overall, 89% of sampled colonies were infested by the mite, with varying prevalence rates across the regions: 95.8% in Oromia, 85.2% in Amhara and 71.9% in SNNPR, indicating the widespread nature of the parasite throughout the country. The varroa infestation levels were lower in local hives (2.6 ± 5.9) than in frame hives (5.0 ± 0.9), and significantly higher in brood bees (5.6 ± 0.8) than in adult bees (1.93 ± 0.17) (p < 0.001). Possible factors contributing to the varied mite prevalence and infestation levels in the country include differences in agro‐ecology, beekeeping practices, host age preference and the nature of bee hives. Therefore, our study provides insights into the current status of varroa prevalence and associated factors across regions in Ethiopia. Further investigation is required to explore the probable impact of the parasite on the health and productivity of local honey bees, in order to design future monitoring strategies.
Optimization of endoscopic ultrasound‐guided tissue sample acquisition for commercially available comprehensive genome profiling
Authors: Ishikawa Kazuma , Ishiwatari Hirotoshi , Sasaki Keiko , Niiya Fumitaka , Satoh Tatsunori , Sato Junya , Matsubayashi Hiroyuki , Minamide Tatsunori , Yamamoto Yoichi , Yoshida Masao , Maeda Yuki , Kawata Noboru , Takada Kazunori , Kishida Yoshihiro , Imai Kenichiro , Hotta Kinichi , Notsu Akifumi , Ono Hiroyuki 
Published: July 2023

AbstractBackground and AimOptimal tumor samples are crucial for successful analysis using commercially available comprehensive genomic profiling (CACGP). However, samples acquired by endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) are occasionally insufficient, and no consensus on the optimal number of needle passes required for CACGP exists. This study aimed to explore the optimal number of needle passes required for EUS‐TA to procure an ideal sample fulfilling the prerequisite criteria of CACGPs.MethodsPatients who underwent EUS‐TA for solid masses between November 2019 and July 2021 were retrospectively studied. The correlation between the acquisition rate of an ideal sample and the number of needle passes mounted on a microscope slide was evaluated. Additionally, the factors predicting a successful analysis were investigated in patients scheduled for CACGP using EUS‐TA‐obtained samples during the same period.ResultsEUS‐TAs using 22‐ and 19‐gauge (G) needles were performed in 336 and 57 patients, respectively. There was a positive correlation between the acquisition rate and the number of passes using a 22‐G needle (38.9%, 45.0%, 83.7%, and 100% for 1, 2, 3, and 4 passes, respectively), while no correlation was found with a 19‐G needle (84.2%, 83.3%, and 85.0% for 1, 2, and 3 passes, respectively). The analysis success rate in patients with scheduled CACGP was significantly higher with ideal samples than with suboptimal samples (94.1%vs55.0%,P < 0.01).ConclusionsThe optimal estimated number of needle passes was 4 and 1–2 for 22‐ and 19‐G needles, respectively.
Geometric morphometric analysis of Pleuronectiformes vertebrae: A new tool to identify archaeological fish remains?
Authors: Dierickx Katrien , Oueslati Tarek , Profico Antonio 
Published: July 2023

AbstractFlatfish (Pleuronectiformes) vertebrae are difficult to identify to species due to the lack of diagnostic features. This has resulted in a lack of understanding of the species abundances across archaeological sites, hindering interpretations of historical fisheries in the North Sea area. We use a new approach, utilising a combined 2D landmark‐based geometric morphometric analysis as an objective and non‐destructive method for species identification of flatfish vertebrae from the North Sea area. Modern specimens were used as a reference to describe the morphological variation between taxa using principal component analysis (PCA) and to trial an automated classification using linear discriminant analysis. Although there is limited distinction between taxa using PCAs, the classification shows high accuracies, indicating that flatfish species identifications using geometric morphometrics are possible. Bone samples (n = 105) from two archaeological sites in the United Kingdom and France were analysed using this approach and their identifications were verified using collagen peptide mass fingerprinting. The success rate of species identification was usually less than 50%, indicating that this technique has limited applicability due to preservation/fragmentation of archaeological fish bone. Nonetheless, this could prove a valuable tool for modern and non‐fragmented samples. Furthermore, the technique applied in this study can be easily adapted to work on other landmark datasets.
Black adolescents' racial discrimination and suicide behaviors: Testing perceived school safety as a protective moderator
Authors: Williams Chelsea D. , Shipman‐Lacewell Jelaina , Shih Shu‐Fang , Wynn Alexandra , de Jesús Elias María , Valrie Cecelia R. 
Published: July 2023

AbstractThe current study examined associations between Black adolescents' (Mage = 15.55, SD = 1.23) racial discrimination and suicide behaviors (i.e., suicide ideation, suicide plan, and suicide attempts), and whether perceived school safety was a protective moderator. Furthermore, we tested gender differences in relations, which were not significant. Racial discrimination predicted greater suicide behaviors, and school safety informed less suicide behaviors. School safety moderated the relation between discrimination and suicide plan, such that at low school safety, discrimination predicted having a suicide plan but was not significant at high school safety. Furthermore, school safety moderated the relation between discrimination and suicide attempts. At low school safety, discrimination predicted more suicide attempts, but was not significant at high school safety.
Mere religiosity is not enough! Spirituality strengthens the relations between religiosity and positive youth development
Authors: Buenconsejo Jet U. , Datu Jesus Alfonso D. 
Published: July 2023

AbstractAlthough prior research shows that either religiosity or spirituality facilitates well‐being, the interaction of both constructs in predicting positive youth development (PYD) in collectivistic contexts remains unknown. This study examined the moderating role of spirituality on the link between religiosity and PYD, including each of its Cs (i.e., competence, confidence, connection, character, and caring) among 1116 Filipino adolescents. Results demonstrate that both religiosity and spirituality are positively correlated with PYD and its dimensions. Furthermore, there is a significant interaction between religiosity and spirituality for the overall PYD construct and the socio‐emotional Cs (i.e., connection, character, and caring). This study highlights the importance of young people's sense of connection with something beyond than themselves (i.e., spirituality) in promoting adolescent thriving.
On Transdisciplinary Possibility: An Interstitial Exploration of American Religious History and Religious Ethics
Authors: Simpson Laura A. 
Published: July 2023

ABSTRACTThis essay explores the intersections of religious ethics and American religious history and advocates for a transdisciplinary approach to scholarship in both disciplines. Four books, each published within the last 4 years, form the foundation of this discussion by modeling distinctive elements of transdisciplinary scholarship: Heathen: Religion and Race in American History by Kathryn Gin Lum; Make Yourselves Gods: Mormons and the Unfinished Business of American Secularism by Peter Coviello; Peaceful Families: American Muslim Efforts Against Domestic Violence by Juliane Hammer; and The Sex Obsession: Perversity and Possibility in American Politics by Janet R. Jakobsen. Each of these texts raises questions that hover at the intersections of religious ethics and American religious history, demonstrating how scholarship in both areas can be strengthened through a destabilization of the disciplines themselves.
Pharmacokinetics of a single oral dose of grapiprant in juvenile pigs (Sus scrofa domestica)
Authors: Kleine Stephanie , Hampton Chiara E. , Smith Christopher , Bussieres Genevieve , Mulon Pierre‐Yves , Seddighi Reza , Cox Sherry , Smith Joe 
Published: July 2023

AbstractBoth pet and research pigs can suffer from some degree of pain from surgery, injuries, or osteoarthritis (OA). Despite this, there is a paucity of data on safe and effective analgesia agents in pigs. Grapiprant is an EP4 antagonist that blocks the action of the pro‐inflammatory prostanoid, PGE2. It has shown efficacy in attenuating pain associated with ovariohysterectomy and OA in dogs. However, there are no data regarding grapiprant in pigs. Therefore, the pharmacokinetic profile of orally administered grapiprant to juvenile pigs (Sus scrofa domestica) was evaluated in this study. Seven juvenile pigs received 12 mg/kg grapiprant orally. Blood was collected from an indwelling jugular catheter using the push–pull method at set timepoints up to 48 hours. Sample analysis was performed with high‐performance liquid chromatography. Mean grapiprant plasma concentration was 164.3 ± 104.7 ng/mL which occurred at 0.8 ± 0.3 h. This study demonstrated that grapiprant concentrations consistent with analgesia in dogs were reached at this dosage in pigs. Further studies are needed to evaluate the efficacy of grapiprant in pigs.