bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogeomorphic Investigation of Keonjhargarh and Patana Blocks, Keonjhar District, Odisha, India
Authors: Majhee R. , Naik A. S. , Kumar A. , Prakash K. , Kumar S. , Dinpuii L. , Kumar G. , Kumar N. 
Published: May 2023

Abstract
Certain parts of Odisha suffer from acute water scarcity at times due to nature's vagaries as well as improper management of water resources. Despite this, the groundwater situation, in general, does not appear to be very dire. Considering the above, an attempt has been made to perform hydrogeomorphic studies in two administrative blocks within Keonjhar District, Keonjhargarh and Patana. The study area extends between latitudes 21°26ꞌ38″N to 21°51ꞌ35″N and longitudes 85°37ꞌ6″E to 86°02ꞌ03″E with a total area of 1053.455 sq. Km. Survey of India Toposheets of 1:50,000 scale and LISS-III satellite data having a resolution of 30 meters are used to prepare several thematic layers, viz., lithological map, slope map, land-use and land cover map, lineament map and lineament density map, drainage map, and geomorphological map. The raster maps of these factors are assigned a fixed score and weight using the Multi Influencing Factor (MIF) technique. All the thematic layers have been integrated with one another in ArcGIS software to delineate groundwater potential zones using the weighted overlay analysis method. The final integrated layer has been classified into five classes, i.e., ‘Very Good,’ ‘Good,’ ‘Moderate,’ ‘Poor,’ and ‘Very Poor, to delineate groundwater potential zones that are validated using hydrological data. The present study has provided insight into the role played by geomorphological, lithological, climatological, and hydrogeological factors that affect the occurrence, distribution, movement, recharge-discharge, and quality of groundwater in the study area.
METTL3 promotes PGC-1α transcription and alleviates mitochrondrial dysfunction of diabetic nephropathy by targeting lncRNA TUG1 m6A modification
Authors: Chen Tong , Wang Juan , Xu Yanyan , Zhu Yonghong , Jin Ying , Fan Qiuling 
Published: May 2023

Abstract
Background: m6A modification plays an important role in various biological processes and can regulate the function of non-coding RNA. Our research group found the m6A level of lncRNA TUG1 was reduced in HK-2 cells cultured with high glucose. Here we study the impact of the important component of m6A-METTL3 on TUG1 in diabetic nephropathy.
Objective: Explore the m6A modification mechanism of lncRNA TUG1 and whether METTL3 can promote PGC-1α transcription, alleviate mitochrondrial dysfunction and diabetic renal injury.
Methods: Test the m6A modification level of the total RNA and lncRNA TUG1 in HK-2 cells and db/db mice.Detect whether lncRNA TUG1 can combine METTL3 and IGF2BP2 by RIP-PCR. Test the mitochondrial function HK-2 cells and db/db mice. Use transmission electron microscope to observe the morphology of mitochondria in HK-2 cells and db/db mice.
Results: RIP-PCR showed that lncRNA TUG1 could bind to METTL3, and IGF2BP2 could recognize the m6A-modified lncRNA TUG1. IGF2BP2 improved the stability of lncRNA TUG1. High glucose and transfection of siTUG1 in HK-2 cells inhibited PGC-1α pathway, and aggravated mitochondrial dysfunction and morphological damages, while overexpression of METTL3 in HK-2 cells and injection of AAV-METTL3 in db/db mice partially rescued the negative effect.
Conclusion: RNA m6A methylation/demethylation imbalance may be mainly regulated by METTL3 in HK-2 cells, and involved in the occurrence and development of diabetic nephropathy. METTL3 can promote the expression of TUG1 through m6A modification in a IGF2BP2-dependent manner in HK-2 cells, and regulate the PGC-1α pathway to alleviate mitochrondrial dysfunction of diabetic nephropathy.
A novel subset of colonocytes targeted by Citrobacter rodentium
elicits epithelial MHCII-restricted help from CD4 T cells
Authors: Weaver Casey , Zindl Carlene , Wilson Garrett , Chadha Awalpreet , Cai Baiyi , Harbour Stacey , Nagaoka-Kamata Yoshiko , Gao Min , Figge David 
Published: May 2023

Abstract
Interleukin (IL)-22 plays a non-redundant role in immune defense of the intestinal barrier1–3. We recently discovered an indispensable role for T cells, but not ILCs, in sustaining IL-22 signaling required for protection of colonic crypts against invasion during infection by the enteropathogen, Citrobacter rodentium (C.r)4. However, identification of the intestinal epithelial cell (IEC) subsets targeted by T cell-derived IL-22 and how T cell-derived IL-22 sustains activation in IECs are undefined. Here, we identify a novel subset of absorptive IECs in the mid-distal colon that are differentially targeted by C.r and are differentially responsive to IL-22 signaling. Importantly, MHCII expression by these colonocytes was required to elicit T cell-activated IL-22 signaling necessary to resist C.r invasion. Our findings explain the basis for the regionalization of the host response to C.r and demonstrate that epithelial cells must elicit MHCII-dependent help from IL-22–producing T cells to orchestrate immune protection in the intestines.
Application of human-computer interaction virtual reality technology in urban cultural creative design
Authors: Han Sujuan , Liu Shuo , Ren Lili 
Published: May 2023

Abstract
As the in-depth expansion and integrated application of information technology, smart city is one of the important directions for nurturing breakthroughs in the new generation of information technology, and an important part of the development of global strategic emerging industries. In the context of world peace, the world economy is developing rapidly and the process of urbanization is accelerating. The construction of a city not only reflects the economic strength of the city, but also is closely related to the life of the citizens. Therefore, this paper aimed to explore a new way of urban cultural creative design. This paper focused on the application of human-computer interaction virtual reality(VR) technology in urban cultural creative design. For this reason, this paper designed an interactive and immersive urban design simulation platform based on VR technology. In order to choose the viewing angle freely and control the design module freely, this paper proposed improved gesture recognition algorithm and anti-collision algorithm. The algorithm designed in this paper can enable designers to have better presentation effects when working on the platform, making architectural design more intuitive. Experiments show that the average accuracy rate of the gesture recognition algorithm designed in this paper reaches 97.3%, which is 4.1% higher than that of the traditional algorithm; and when the anti-collision algorithm in this paper is set to the optimal parameters, the accuracy rate is as high as 95%. These results fully demonstrate that the human-computer interaction VR technology design platform proposed in this paper has good design performance and can be applied to urban cultural creative design.
Oxidative responses in small juveniles of Colossoma macropomum anesthetized and sedated with Ocimum gratissimum L. essential oil
Authors: Ferreira Andre Lima , Silva Walisson de Souza e , Silva Hugo Napoleão Pereira da , Milarch Carine de Freitas , Palheta Glauber David Almeida , Heinzmann Berta Maria , Pinheiro Carlos Garrido , Baldisserotto Bernardo , Favero Gisele Cristina , Luz Ronald Kennedy 
Published: May 2023

Abstract

This study evaluated the use of essential oil of Ocimum gratissimum (EOOG) for anesthesia and in transport of Colossoma macropomum. Experiment 1, Test 1, anesthesia induction and recovery times were determined using different EOOG concentrations (0, 20, 50, 100, 200, 300 mg L− 1), with two size classes: Juveniles I (0.86 g) and Juveniles II (11.46 g) (independent tests in a completely randomized design). Based on the results of Test 1, in Test 2 Juveniles II were exposed to EOOG concentrations: 0, 20, 100 mg L− 1. Tissue samples were collected immediately after induction and 1 h post-recovery, to assess oxidative status variables. Experiment 2, Juveniles I (0.91 g) and Juveniles II (14.76 g) were submitted to transport in water with different concentrations of EOOG (0, 5, 10 mg L− 1) (independent tests in a completely randomized design). The effects on oxidative status variables were evaluated. Concentrations between 50 and 200 mg L− 1 EOOG can be indicated for Juveniles I, while concentrations between 50 and 100 mg L− 1 EOOG for Juveniles II. The concentration of 100 mg L− 1 EOOG was able to prevent oxidative damage in the liver. In Experiment 2, the concentrations of 5 and 10 mg L− 1 EOOG added to the transport water caused sedation for both studied size classes of juveniles and did not cause oscillations in water quality variables nor any mortality. The concentration of 10 mg L− 1 EOOG improved the oxidative status. It can be concluded that EOOG can be used for anesthesia and transport of C. macropomum.
Buckling analysis of sandwich cylindrical micro shells with functionally graded porous core subjected to uniform magneto-electric fields based on couple stress theory
Authors: Mohammed Layth , Biglari Hasan , Tahami Farid Vakili 
Published: May 2023

Abstract
This study examines the buckling behavior of sandwich cylindrical microshells made of functionally graded materials under uniform magneto-electric load. The analysis utilizes a high-order shear and normal deformation shell theory, incorporating a material length scale parameter from the couple stress theory. Hamilton's principle is used to derive the equations of motion and boundary conditions at both ends. The Navier procedure is employed to determine the dimensionless critical buckling load for three types of functionally graded sandwich cylindrical microshells, with a vector used to represent the uniform magneto-electric fields at both ends. Results indicate that angled functionally graded sandwich cylindrical microshells exhibit higher stiffness in couple stress theory than in normal FGS, resulting in an increased dimensionless critical buckling load. Moreover, the material length scale parameter has a significant impact on the dimensionless critical buckling load across various axial and circumferential wavenumbers. An increase in power-law index n for specific values of dimensionless length scale parameter (l/h) leads to a decrease in DCB load according to MCST.
Robotized indoor phenotyping allows genomic prediction of adaptive traits in the field
Authors: Tardieu Francois , Bouidghaghen Jugurta , Moreau Laurence , Beauchene Katia , Chapuis Romain , Mangel Nathalie , Bosquet LLorenç Cabrera , Welcker Claude , Bogard Matthieu 
Published: May 2023

Abstract
Breeding for resilience to climate change requires considering adaptive traits such as plant architecture, stomatal conductance and growth, beyond the current selection for yield. Robotized indoor phenotyping allows measuring such traits at high throughput for speed breeding, but is often considered as non-relevant for field conditions. We show that maize adaptive traits can be inferred in different fields, based on genotypic values obtained indoor and on environmental conditions in each considered field. The modelling of environmental effects allowed translation from indoor to fields, but also from one field to another field. Furthermore, genotypic values of considered traits matched between indoor and field conditions. Genomic prediction resulted in adequate ranking of genotypes for the tested traits, although with lesser precision for elite varieties presenting reduced phenotypic variability. Hence, it distinguished genotypes with high or low values for adaptive traits, conferring either spender or conservative strategies for the diversity of future climates.
Implementing the free HPV vaccination for eligible girls in Shenzhen, Guangdong: Experience, challenges, and lessons
Authors: Wu Dadong , Liu Peiyi , Song Danhong , Wang He , Chen Siqi , Tang Wanyi , Zhao Xuelian , Zhao Fanghui , Wang Yueyun 
Published: May 2023

Abstract
Cervical cancer is a major public health concern in China, accounting for almost one-fifth of the global incidence and mortality. The recently prequalified domestic bivalent HPV vaccine offers a practical and feasible preventive measure. In response to the WHO's call for action, the National Health Commission established an Action Plan to eliminate cervical cancer by 2030, with the promotion of HPV vaccination for eligible girls as a critical step. Despite this, implementation of the vaccination programme has been patchy, with very low coverage among eligible girls. To address this, a demonstration project was launched in Shenzhen in December 2021 to promote the inclusion of HPV vaccine in the immunisation programme and to address existing barriers to implementation. Using multiple sources of data, this article presents a case study of the demonstration project, analysing its impact on increasing the HPV vaccination rate among eligible girls and identifying any challenges encountered during implementation. The demonstration project has shown promising results in increasing the HPV vaccination rate, promoting public awareness and acceptance of the domestic HPV vaccine, and establishing a model for scaling up the vaccination programme at the municipal level. The success of the project can be attributed to several factors, including the strong governmental commitment, sufficient funding, multi-sectoral collaboration, improved vaccine accessibility and affordability, enhanced capacity of primary care practitioners, and effective health education and communication strategies. Lessons learned from Shenzhen can provide valuable insights for future advocacy and implementation in other areas of China, but challenges must be addressed to achieve universal coverage. These challenges include vaccine hesitancy, expanding the programme to cover a broader age range, and ensuring consistent quality of vaccination services in primary care facilities. Overcoming these challenges will require innovative strategies, public-private partnerships, and sustained funding and resources. Future research should focus on evaluating the long-term effectiveness of the HPV vaccination programme and identifying contextual factors that may impact implementation in different settings. Overall, the effective control of cervical cancer in China will rely on the “political will” to ensure that preventive interventions are incorporated into policies and that programme coverage is equitable and universal.
Identifying inpatient hospitalizations with continuous electroencephalogram monitoring from administrative data
Authors: Fernandes Marta , Westover M. Brandon , Zafar Sahar F. 
Published: May 2023

Abstract
Background Continuous electroencephalography (cEEG) is increasingly utilized in hospitalized patients to detect and treat seizures. Epidemiologic and observational studies using administrative datasets can provide insights into the comparative and cost effectiveness of cEEG utilization. Defining patient cohorts that underwent acute inpatient cEEG from administrative datasets is limited by the lack of validated codes differentiating elective epilepsy monitoring unit (EMU) admissions from acute inpatient hospitalization with cEEG utilization. Our aim was to develop hospital administrative data-based models to identify acute inpatient admissions with cEEG monitoring and distinguish them from EMU admissions.Methods This was a single center retrospective cohort study of adult (≥ 18 years old) inpatient admissions with a cEEG procedure (EMU or acute inpatient) between January 2016-April 2022. The gold standard for acute inpatient cEEG vs. EMU was obtained from the local EEG recording platform. An extreme gradient boosting model was trained to classify admissions as acute inpatient cEEG vs. EMU using administrative data including demographics, diagnostic and procedure codes, and medications.Results There were 9,523 patients in our cohort with 10,783 hospital admissions (8.5% EMU, 91.5% acute inpatient cEEG); with average age of 59 (SD 18.2) years; 46.2% were female. The model achieved an area under the receiver operating curve of 0.92 (95% CI [0.91–0.94]) and area under the precision-recall curve of 0.99 [0.98–0.99] for classification of acute inpatient cEEG.Conclusions Our model has the potential to identify cEEG monitoring admissions in larger cohorts and can serve as a tool to enable large-scale, administrative data-based studies of EEG utilization.
Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy
Authors: Vasanthi Suraj S. , Rao Nikhil S. , Samidurai Manikandan , Massey Nyzil , Meyer Christina , Gage Meghan , Kharate Mihir , Almanza Aida , Wachter Logan , Mafuta Candide , Trevino Lily , Carlo Adriana M , Bryant Elijah , Corson Brooke E. , Wohlgemuth Morgan , Ostrander Morgan , Wang Chong , Thippeswamy Thimmasettappa 
Published: May 2023

AbstractBackgroundAcute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediatestatus epilepticus(SE), reactive gliosis, neurodegeneration, and epileptogenesis as a consequence. Medical countermeasures (MCMs- atropine, oximes, benzodiazepines), if administered in < 20 minutes of OPNA exposure, can control acute symptoms and mortality. However, MCMs alone are inadequate to prevent OPNA-induced brain injury and behavioral dysfunction in survivors. We have previously shown that OPNA exposure-induced SE increases the production of inducible nitric oxide synthase (iNOS) in glial cells in both short- and long- terms. Treating with a water soluble and highly selective iNOS inhibitor, 1400W, for three days significantly reduced OPNA-induced brain changes in those animals that had mild-moderate SE in the rat DFP model. However, such mitigating effects and the mechanisms of 1400W are unknown in a highly volatile nerve agent GD exposure.MethodsMixed-sex cohort of adult Sprague Dawley rats were exposed to GD (132µg/kg, s.c.) and immediately treated with atropine (2mg/kg, i.m) and HI-6 (125mg/kg, i.m.). Severity of seizures were quantified for an hour and treated with midazolam (3mg/kg, i.m.). An hour post-midazolam, 1400W (20mg/kg, i.m.) or vehicle was administered daily for two weeks. After behavioral testing and EEG acquisition, animals were euthanized at 3.5 months post-GD. Brains were processed for neuroinflammatory and neurodegeneration markers. Serum and CSF were used for nitrooxidative and proinflammatory cytokines assays.ResultsWe demonstrate a significant long-term (3.5 months post-soman) disease-modifying effect of 1400W in animals that had severe SE for > 20min of continuous convulsive seizures. 1400W significantly reduced GD-induced motor and cognitive dysfunction; nitrooxidative stress (nitrite, ROS; increased GSH: GSSG); proinflammatory cytokines in the serum and some in the cerebrospinal fluid (CSF); epileptiform spikes and spontaneously recurring seizures (SRS) in males; reactive gliosis (GFAP + C3 and IBA1 + CD68 positive glia) as a measure of neuroinflammation, and neurodegeneration (including parvalbumin positive neurons) in some brain regions.ConclusionThese findings demonstrate the long-term disease-modifying effects of a glial-targeted iNOS inhibitor, 1400W, in a rat GD model by modulating reactive gliosis, neurodegeneration, and neuronal hyperexcitability.
Analysis and design of three-coil radio-energy-efficient transmission system with constant current and constant voltage characteristics
Authors: Yang Tong , Gong Lijiao , Zhang PengFei , Ma XinXin , Guo WangWang , Huang Bo 
Published: May 2023

Abstract
To meet the requirements of constant current (CC) or constant voltage (CV) power supply for sensors and other electric loads, this study proposed two types of three-coil WPT (wireless power transfer) system: one with relay coil and another with dual transmitter and single receiver. On the basis of actual coil parameters and target gains, the transmission characteristics of different circuits were analyzed, the design method of compensation network for three-coil WPT systems with CC and CV characteristics was given, and the transmission efficiency and lateral offset competence of the two designs were compared under the same load resistance. Finally, the correctness and effectiveness of the proposed system’s CV and CC output characteristics and its parameter design method were verified through physical experiments. Results show that under CC condition, the transmission efficiency of the three-coil system with relay coil is lower than the dual-transmitter and single-receiver type. Moreover, under CV, the transmission efficiency and offset characteristics of the former are higher than the latter.
Causal Relationship between Genetically Predicted Psychiatric Disorders and Colorectal Cancer Risk: A Two-Sample Mendelian Randomization
Authors: Liu Yi-Fan , Jia Hui , Wu Miao-Qing , Cao Di , Lv Guang-Zhao , Li Cong , Zhang Rong-Xin , Chen Gong 
Published: May 2023

Abstract
Purpose The main purpose of this study was to examine the causal relationship between various psychiatric disorders and colorectal cancer risk using a two-sample Mendelian randomization analysis. The research question aimed to determine whether a specific psychiatric disorder has a causal link with colorectal cancer.Methods We utilized publicly accessible genome-wide association studies (GWAS) data on psychiatric disorders, including Attention Deficit Hyperactivity Disorder (ADHD), Major Depressive Disorder (MDD), Insomnia, Schizophrenia (SCZ), Bipolar Disorder (BIP), Worry, Panic, Autism Disorder, and Neuroticism. Causal analyses were executed using inverse variance weighting (IVW) and supplemented with methods for sensitivity assessment, pleiotropy testing, and outlier exclusion.Results Our analysis identified a causal relationship solely between BIP and colorectal cancer (OR = 0.90, 95% CI: 0.81–0.99, P = 0.03). Additional analysis revealed a causal effect of type I BIP on colorectal cancer (OR = 0.90, 95% CI: 0.93–0.98, P = 0.01). We found no evidence of a causal impact for other mental disorders on colorectal cancer risk.Conclusion Our study implies that type I BIP exerts a negative causal influence on colorectal cancer risk, offering new perspectives for the study of prevention strategies and pathological mechanisms of colorectal cancer.
Learning Modular Language-Conditioned Robot Policies through Attention
Authors: Zhou Yifan , Sonawani Shubham , Phielipp Mariano , Amor Heni Ben , Stepputtis Simon 
Published: May 2023

Abstract
Training language-conditioned policies is typically time-consuming and resource-intensive. Additionally, the resulting controllers are tailored to the specific robot they were trained on, making it difficult to transfer them to other robots with different dynamics. To address these challenges, we propose a new approach called Hierarchical Modularity, which enables more efficient training and subsequent transfer of such policies across different types of robots. The approach incorporates Supervised Attention which bridges the gap between modular and end-to-end learning by enabling the re-use of functional building blocks. In this contribution, we build upon our previous work, showcasing the extended utilities and improved performance by expanding the hierarchy to include new tasks and introducing an automated pipeline for synthesizing a large quantity of novel objects. We demonstrate the effectiveness of this approach through extensive simulated and real-world robot manipulation experiments.