bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levothyroxine therapy, calculated deiodinases activity and basal metabolic rate in obese or nonobese patients after total thyroidectomy for differentiated thyroid cancer, results of a retrospective observational study
Authors: Le Moli Rosario , Malandrino Pasqualino , Russo Marco , Tumino Dario , Piticchio Tommaso , Naselli Adriano , Rapicavoli Valentina , Belfiore Antonino , Frasca Francesco 
Published: February 2023

AbstractIntroductionTherapy for hypothyroid obese patients is still under definition since the thyrotropin‐stimulating hormone (TSH) level is a less reliable marker of euthyroidism than nonobese patients. Indeed, TSH levels positively correlate with body mass index (BMI), and this increase may be a compensatory mechanism aimed at increasing energy expenditure in obese people. In contrast, the correlation of BMI with thyroid hormone levels is not completely clear, and conflicting results have been obtained by several studies. The L‐T4 replacement dose is more variable in obese hypothyroid patients than in nonobese patients, and a recent study indicated that the L‐T4 replacement dose is related to lean body mass in obese thyroidectomized patients. We aimed to study the correlations of L‐T4‐administered dose, thyroid hormone levels and TSH secretion with basal metabolic rate (BMR) and total calculated deiodinase activity (GD) in obese and nonobese athyreotic patients. We also looked for individualized L‐T4 replacement dose set points to be used in clinical practice.MethodsWe studied retrospectively 160 athyreotic patients, 120 nonobese and 40 obese. GD was calculated by SPINA Thyr 4.2, the responsiveness of the hypothalamic/pituitary thyrotrope by Jostel's thyrotropin (TSH) index and BMR by the Mifflin‐St. Jeor formula, the interplay of GD and BMR with L‐T4, thyroid hormones and TSH index (TSHI) was also evaluated.ResultsIn our study, the L‐T4 dose was an independent predictor of GD, and approximately 30% of athyreotic patients under L‐T4 therapy had a reduced GD; FT4 levels were higher and negatively modulated by BMR in obese athyreotic patients respect to nonobese, in these patients a T4 to T3 shunt, in terms of TSHI suppression is observed suggesting a defective hypothalamic pituitary T4 to T3 conversion and a resistance to L‐T4 replacement therapy.ConclusionsL‐t4 dose is the most important predictor of GD, BMR modulates T4 levels in obese athyreotic patients that are resistant to L‐T4 replacement therapy.
The cardiovascular effects of SGLT2 inhibitors, RAS inhibitors, and ARN inhibitors in heart failure
Authors: Ji Peng‐juan , Zhang Zhuo‐ya , Yan Qi , Cao Hui‐li , Zhao Ya‐jing , Yang Bin , Li Jin 
Published: February 2023

AbstractAimsNo studies have comprehensively compared the efficacy of sodium‐glucose cotransporter‐2 (SGLT2) inhibitors, renin–angiotensin system (RAS) inhibitors, and angiotensin receptor neprilysin (ARN) inhibitors based on different type of heart failure, including heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). The aim of this network meta‐analysis was to evaluate the relative efficacy of SGLT2 inhibitor (SGLT2i), RAS inhibitor (RASi) and ARN inhibitor (ARNI) in different types of heart failure.MethodsA systemic literature search was performed from inception to 19 November 2022 for randomized control trials assessing the risk of cardiovascular (CV) death or hospitalization for heart failure (HHF) of these drugs in HF. A network meta‐analysis was performed. Risk ratio (RR) with 95% confidence intervals (CI) were synthesized.ResultsSeventeen studies were selected with a total of 61 489 patients. In patients with HFrEF, ARNI led to a reduced risk of a composite outcome of CV death or HHF when compared with placebo (RR = 0.83, 95% CI 0.77–0.89). Similar trends were observed when focusing on the outcome of CV death or HHF alone. In patients with HFpEF, SGLT2i showed the beneficial effects on the CV death or HHF events when compared with placebo and RASi (RR = 0.82, 95% CI 0.74–0.92; RR = 1.16, 95% CI 1.02–1.31). For CV death, all these three drugs could not show beneficial effects in HFpEF. For the incidence of HHF in HFpEF, both SGLT2i and ARNI demonstrated the beneficial effects but SGLT2i was superior to ARNI. There were no differences in the events of discontinuation under these drugs when compared with placebo or each other in either HFrEF or HFpEF patients. SGLT2i showed the least renal injury among these interventions in HFrEF and there were no differences in the incidence of renal injury of these interventions in HFpEF.ConclusionsAmong these drugs, ARNI showed the greatest ability to lower the incidence of CV death or HHF and SGLT2i exerted the least renal injury in patients with HFrEF. In patients with HFpEF, SGLT2i was associated with a reduction in the risk of CV death or HHF. There were no differences in the incidence of renal injury of these interventions in HFpEF. The intolerance of these drugs were comparable in both HFrEF and HFpEF.
Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels
Authors: Ráduly Arnold Péter , Tóth Attila , Sárkány Fruzsina , Horváth Balázs , Szentandrássy Norbert , Nánási Péter P. , Csanádi Zoltán , Édes István , Papp Zoltán , Borbély Attila 
Published: February 2023

AbstractAimsHeart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers for patients with advanced HFrEF. Omecamtiv mecarbil (OM) is the first direct myosin activator with promising results in clinical studies. Here, we aimed to elucidate the cellular mechanisms of the positive inotropic effect of OM in a comparative in vitro investigation where Ca2+‐sensitizing positive inotropic agents with distinct mechanisms of action [EMD 53998 (EMD), which also docks on the myosin molecule, and levosimendan (Levo), which binds to troponin C] were included.MethodsEnzymatically isolated canine cardiomyocytes with intact cell membranes were loaded with Fura‐2AM, a Ca2+‐sensitive, ratiometric, fluorescent dye. Changes in sarcomere length (SL) and intracellular Ca2+ concentration were recorded in parallel at room temperature, whereas cardiomyocyte contractions were evoked by field stimulation at 0.1 Hz in the presence of different OM, EMD, or Levo concentrations.ResultsSL was reduced by about 23% or 9% in the presence of 1 μM OM or 1 μM EMD in the absence of electrical stimulation, whereas 1 μM Levo had no effect on resting SL. Fractional sarcomere shortening was increased by 1 μM EMD or 1 μM Levo to about 152%, but only to about 128% in the presence of 0.03 μM OM. At higher OM concentrations, no significant increase in fractional sarcomere shortening could be recorded. Contraction durations largely increased, whereas the kinetics of contractions and relaxations decreased with increasing OM concentrations. One‐micromole EMD or 1 μM Levo had no effects on contraction durations. One‐micromole Levo, but not 1 μM EMD, accelerated the kinetics of cardiomyocyte contractions and relaxations. Ca2+ transient amplitudes were unaffected by all treatments.ConclusionsOur data revealed major distinctions between the cellular effects of myofilament targeted agents (OM, EMD, or Levo) depending on their target proteins and binding sites, although they were compatible with the involvement of Ca2+‐sensitizing mechanisms for all three drugs. Significant part of the cardiotonic effect of OM relates to the prolongation of systolic contraction in combination with its Ca2+‐sensitizing effect.
New remote method to systematically extract bedrock channel width of small catchments across large spatial scales using high‐resolution digital elevation models
Authors: Eidmann Johanna Sophie , Gallen Sean 
Published: February 2023

AbstractBedrock river width is an essential geometric parameter relevant to understanding flood hazards and gauging station rating curves, and is critical to stream power incision models and many other landscape evolution models. Obtaining bedrock river width measurements, however, typically requires extensive field campaigns that take place in rugged and steep topography where river access is often physically challenging. Although prior work has turned to measuring channel width from satellite imagery, these data present a snapshot in time, are typically limited to rivers ≥ 10–30 m wide due to the image resolution, and are physically restricted to areas devoid of vegetation. For these reasons, we are generally data limited, and the factors impacting bedrock channel width remain poorly understood. Due to these limitations, researchers often turn to assumptions of width‐scaling relationships with drainage area or discharge to estimate bedrock channel width. Here we present a new method of obtaining bedrock channel width at a desired river discharge through the incorporation of a high‐resolution bare‐earth digital elevation model (DEM) using MATLAB Topotoolbox and the HEC‐RAS river analysis system. We validate this method by comparing modeled results to US Geological Survey (USGS) field measurements at existing gauging stations, as well as field channel measurements. We show that this method can capture general characteristics of discharge rating curves and predict field‐measured channel widths within uncertainty. As high‐resolution DEMs become more available across the United States through the USGS three‐dimensional elevation program (3DEP), the future utility of this method is notable. Through developing and validating a streamlined, open‐source, and freely available workflow of channel width extraction, we hope this method can be applied to future research to improve the quantity of channel width measurements and improve our understanding of bedrock channels.
Methyl jasmonate treatment alleviates chilling injury and improves antioxidant system of okra pod during cold storage
Authors: Liu Yunfen , Liu Yu , Chen Qiumei , Yin Feilong , Song Mubo , Cai Wen , Shuai Liang 
Published: February 2023

AbstractOkra pod is sensitive to low temperature, which results in chilling injury under improper low‐temperature storage. This study aimed to evaluate the effect of different concentrations of methyl jasmonate (MeJA) treatment on okra pod stored at 4 ± 1°C for 12 days and illuminate the mechanism of MeJA alleviating chilling injury. Compared to the control, MeJA treatments maintained lower relative electric conductivity (REC), chilling injury (CI) degree, and lignin content, as well as higher total soluble solids, total soluble sugar, pectin content, and chlorophyll content. The factor analysis was applied to comprehensively evaluate the effects of MeJA so that 1 μmol/L MeJA was screened as the optimum concentration to maintain the okra quality throughout the storage time. In contrast with control, MeJA not only accelerated the generation of antioxidant substances (phenolics and flavonoids) but also increased the superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and peroxidase (POD) activity, inhibited malondialdehyde (MDA), hydrogen peroxide (H2O2) content accumulation, and the polyphenol oxidase (PPO) activity. This work confirmed that MeJA could effectively alleviate chilling injury and maintain the quality during cold‐stored by regulating reactive oxygen species (ROS) metabolism. These results provide theoretical guidance for the application of MeJA in okra storage and preservation.
Big Things, Small Packages: An Update on Microalgae as Sustainable Sources of Nutraceutical Peptides for Promoting Cardiovascular Health
Authors: Ejike Chukwunonso E. C. C. , Ezeorba Timothy P. C. , Ajah Obinna , Udenigwe Chibuike C. 
Published: February 2023

AbstractIn 2017, a review of microalgae protein‐derived bioactive peptides relevant in cardiovascular disease (CVD) management was published. Given the rapid evolution of the field, an update is needed to illumininate recent developments and proffer future suggestions. In this review, the scientific literature (2018–2022) is mined for that purpose and the relevant properties of the identified peptides related to CVD are discussed. The challenges and prospects for microalgae peptides are similarly discussed. Since 2018, several publications have independently confirmed the potential to produce microalgae protein‐derived nutraceutical peptides. Peptides that reduce hypertension (by inhibiting angiotensin converting enzyme and endothelial nitric oxide synthase), modulate dyslipidemia and have antioxidant and anti‐inflammatory properties have been reported, and characterized. Taken together, future research and development investments in nutraceutical peptides from microalgae proteins need to focus on the challenges of large‐scale biomass production, improvement in techniques for protein extraction, peptide release and processing, and the need for clinical trials to validate the claimed health benefits as well as formulation of various consumer products with the novel bioactive ingredients.
Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop‐signal task
Authors: Elton Amanda , Allen John Hunter , Yorke Mya , Khan Farhan , Xu Peng , Boettiger Charlotte A. 
Published: February 2023

AbstractChildhood maltreatment (CM) and a family history (FH) of alcohol use disorder (AUD) are each associated with increased impulsivity. However, their unique or shared brain targets remain unknown. Furthermore, both CM and FH demonstrate sex‐dependent effects on brain and behavior. We hypothesized that CM and FH interact in brain regions involved in impulsivity with sex‐dependent effects. 144 first‐year college students (18–19 years old) with varying experiences of CM and/or FH but without current AUD performed an fMRI stop‐signal task. We tested interactions between FH, CM, and sex on task performance and blood oxygen level‐dependent (BOLD) signal during successful inhibitions. We examined correlations between BOLD response and psychiatric symptoms. Significant three‐way interactions of FH, CM, and sex were detected for brain and behavioral data, largely driven by male subjects. In males, CM was associated with poorer response inhibition but only for those with less FH; males with higher levels of both CM and FH demonstrated better response inhibition. Three‐way interaction effects on voxel‐wise BOLD response during response inhibition were found in bilateral middle frontal gyrus, left inferior frontal gyrus, dorsomedial prefrontal cortex, and posterior cingulate cortex. Network‐level analyses implicated the left frontoparietal network, executive control network, and default‐mode network. Greater BOLD response in these networks correlated with lower depressive, impulsive, and attentional symptoms, reduced alcohol misuse, greater resilience scores, and heightened trait anxiety. The results highlight sex‐divergent effects of heritable and environmental risk factors that may account for sex‐dependent expression of psychopathology in response to risk factors.
Long‐term mortality and cardiovascular events of seven angiotensin receptor blockers in hypertensive patients: Analysis of a national real‐world database: A retrospective cohort study
Authors: Lee Wonjae , Kang Jeehoon , Park Jun‐Bean , Seo Won‐Woo , Lee Seung‐Yeon , Lim Woo‐Hyun , Jeon Ki‐Hyun , Hwang In‐Chang , Kim Hack‐Lyoung 
Published: February 2023

AbstractBackground and AimsAlthough many angiotensin receptor blockers (ARBs) are widely used, comparative data regarding their impact on clinical outcomes are limited. We aimed to compare the clinical effectiveness of seven ARBs on long‐term cardiovascular outcomes in Korean patients with hypertension.MethodsUsing the Korean National Health Insurance Service database, the data of 780,785 patients with hypertension without cardiovascular disease (CVD) who initiated ARB treatment (candesartan, fimasartan, irbesartan, losartan, olmesartan, telmisartan, or valsartan) in 2014 and underwent this treatment for more than 6 months, were analyzed. Cox‐regression analysis was performed using Losartan as a comparator, as it was the most widely used drug, by adjusting age, sex, diabetes, dyslipidemia, smoking, alcohol drinking, exercise, body mass index, systolic blood pressure, albuminuria, estimated glomerular filtration rate, and concomitant medications. The occurrence of mortality and the rate of major adverse cardiovascular events (MACEs) of the six ARBs was compared with that of losartan.ResultsThe median follow‐up duration was 5.94 (interquartile range, 5.87–5.97) years. In the crude analysis of all‐cause mortality and MACEs, fimasartan exhibited the lowest event rates. In the Cox‐regression analysis with adjustment, there was no significant difference in all‐cause mortality among ARBs. The risk of MACEs with ARBs was similar to that with losartan, although the risks with irbesartan (hazard ratio [HR], 1.079; 95% confidence interval [CI], 1.033–1.127; p = 0.007) and candesartan (HR: 1.066; 95% CI, 1.028–1.106; p = 0.015) were slightly higher.ConclusionIn a Korean population of patients with hypertension without CVD, six different ARBs showed similar efficacy to losartan in terms of long‐term mortality and MACEs. Further well‐designed prospective studies are required to confirm our findings.
Towards the development of an isotope‐enabled rainfall‐runoff model: Improving the ability to capture hydrological and anthropogenic change
Authors: Watson Andrew , Vystavna Yuliya , Kralisch Sven , Helmschrot Jörg , van Rooyen Jared , Miller Jodie 
Published: February 2023

AbstractGlobal hydrological alterations are being driven by climate change. However, while modelling tools have been instrumental in identifying these changes, their calibration is often dependent solely on streamflow data, which limits the ability to simulate important hydrological processes with the required level of certainty. Constraining hydrological process simulations is required to identify robust model parameters, reducing model uncertainty and providing a baseline model for climate‐related risk assessments. In this study, stable isotope measurements of rainwater, groundwater and stream water (δ2H and δ18O), together with an end member mixing analysis (EMMA) (as a post‐processing step) were integrated with the Jena adaptative modelling system (JAMS)/J2000 rainfall‐runoff model, named J2000iso. The J2000iso models of δ2H and δ18O were able to achieve a streamflow Nash–Sutcliffe efficiency (NSE) of 0.75 and 0.72 and an isotope mixing Kling–Gupta efficiency (KGE) of 0.51 and 0.60, respectively. Compared with the base version, the J2000iso had a much smaller variability with 56% less ensemble variance in the NSE, 13% more simulated interflow which resulted in a better soil‐moisture simulation at an observation point, and lower simulated flow component uncertainty. The J2000iso δ2H model was more robust than the base version during a subsequent validation in terms of KGE and Bias with 0.60 and 0.002 compared with 0.51 and −0.14 for the base version. The EMMA provided a means to improve the hydrograph separation ability of the JAMS/J2000. As many catchments around the world are still ungauged and are affected by anthropogenic activities, the development and enhancement of isotope‐enabled modelling provides a means to improve the simulation of key hydrological processes.
ZIF‐8‐Derived Dual Metal (Fe, Ni)‐Nitrogen‐Doped Porous Carbon for Superior ORR Performance in Universal Acid‐Base Properties Solutions
Authors: Zhou Zijian , Fang Huiyuan , Liu Yumin , He Lijuan , Zhao Junhui , Liu Mingshuang , Yang Weihua 
Published: February 2023

AbstractFe‐N/C catalysts have currently comparable oxygen reduction reaction (ORR) activity to Pt/C catalysts, which are up for consideration as the most promising non‐precious metal material for research. In spite of this, its development and application are limited by the Fenton effect and insufficient stability. Herein, we have fabricated a FeNi‐nitrogen‐doped porous carbon (FeNi‐NPC) catalyst using solvent thermal method, made from the bimetallic (Fe, Ni)‐doped ZIF‐8. A soft template of glucose was used to control the pore structure and active specific surface area of the catalyst. With the benefit of the electronic effect of the bimetal, FeNi‐NPC catalysts exhibit superior ORR activity and stability to Pt/C catalysts in both acidic (E1/2=0.8672 V) and alkaline (E1/2=0.8663 V) conditions. FeNi‐NPC demonstrated peak power densities in proton exchange membrane fuel cells (PEMFC) of up to 865 mW cm−2, which exceeds the currently reported M‐N/C catalysts. The work presented here will lead to the design of efficient ORR electrocatalysts in PEMFC devices.
Quantitative Chemoproteomic Methods for Reactive Cysteinome Profiling
Authors: Xiao Weidi , Chen Ying , Wang Chu 
Published: February 2023

AbstractReactive cysteines often serve as functional sites on proteins and play important regulatory roles in various biological processes. A chemoproteomic method named “isoTOP‐ABPP” has enabled global profiling of cysteine reactivity in native systems and greatly increased our understanding on reactive cysteinome. This elegant method and its derived chemoproteomic technologies are now widely applied in profiling of reactive cysteinome and the associated post‐translational modifications, discovery of covalent ligands for undruggable targets as well as mechanistic investigation of various biological processes. In this review, we will briefly go over the history of isoTOP‐ABPP, summarize recent developments and applications of chemoproteomic technology in reactive cysteinome profiling, and discuss future directions in this field.
On a persisting curious double standard in behavior analysis: Behavioral scholars' perspectives on procedural fidelity
Authors: St. Peter Claire C. , Brand Denys , Jones Stephanie H. , Wolgemuth Jennifer R. , Lipien Lodi 
Published: February 2023

AbstractProcedural fidelity is the extent to which independent variables are implemented as designed. Despite 40 years of discussion about the importance of procedural fidelity for behavioral research, reporting of fidelity data remains an uncommon practice in behavior‐analytic journals. Researchers have speculated about reasons for underreporting, but the perspectives of scholars about when reporting is warranted or necessary have not yet been explored. Thus, the purpose of this study was to evaluate possible reasons for infrequent reporting of fidelity data in behavior‐analytic studies. To address this purpose, we conducted focus groups with scholars in applied behavior analysis. Five themes emerged regarding why procedural fidelity data are not typically reported. We provide a discussion about how these themes are interrelated and offer suggestions and recommendations to assist with the collection and reporting of fidelity data.