bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROBOTIC APPROACH IN 10 CASES OF CORPOROCAUDAL PANCREATECTOMY. INITIAL EXPERIENCE OF A BILIO-PANCREATIC UNIT
Authors: Sánchez-Bueno F , Gil Vazquez P J , Ferreras Martínez D , Gómez Pérez B , Gómez Boch F , Alcaraz Solano A , Cugat Andorra E 
Published: January 2023

Abstract

Introduction
The aim of this paper is to analyze the validity and safety of a new robotic approach implantation program in the corporocaudal pancreatectomy (PCC) in a Bilio-Pancreatic Unit, evaluating morbi-mortality and hospital stay.

Methods
Given the controversy of which is the best therapeutic option in distal pancreatectomy in clinical process surgery tributaries, we designed this prospective, non-randomized, single-center study of pancreatic resection with Robotic approach). Ten patients (7 women and 3 men) were included, with a mean age of 57.8 years, (range 36–73 years). In all patients, the body mass index was higher than 30 and the diagnosis was made with a preoperative computed tomography.

Results
The robotic approach was successful in all cases, performing a corporal-caudal pancreatectomy associated with splenectomy. Blood loss was minimal during intervention, not requiring any blood transfusion. The mean operative time was 135.8 minutes. Conversion to open surgery was not necessary. Three patients had postoperative complications when a CT scan diagnosed an intra-abdominal collection in the left hypocondrium. It was resolved by percutaneous radiological drainage. Median hospital stay was 4 days (3–15). There was not perioperative mortality at 90 days. Anatomopathological study showed 5 mucinous cystic neoplasms, 2 adenocarcinomas of the pancreas and 3 well-differentiated neuroendocrine tumors. Mean size of the lesions were 4.8 cm (2.4–9).

Conclusions
Robotic distal pancreatectomy is an effective and safe technique. In addition, postoperative morbidity and hospital stay decreases.
UNUSUAL SURGERY FOR A HEPATOCARCINOMA DISGUISED AS AN ADENOMA
Authors: Perra T , Porcu A 
Published: January 2023

Abstract

Introduction
Hepatic neoformations should always be adequately evaluated, even if they are suspected of being benign. We present a case of suspected hepatic adenoma that turned out to be hepatocarcinoma.

Clinical case
A 38-year-old woman was admitted to the general surgery clinic due to the ultrasound finding of a hepatic neoplasm. Preoperative imaging tests and biopsy led to a diagnosis of hepatic adenoma. An abdominal CT scan showed a polylobulated expansive lesion occupying almost completely hepatic segments 5, 6 and 8 (11 cm) and an additional lesion in S8 (15 mm). The main lesion was in contact with the right hepatic vein, the middle hepatic vein, the retrohepatic vena cava, and the portal vein bifurcation. Surgical exeresis of the neoformation was performed. The surgical approach required subluxation of the liver to get direct control of the veins, rather than proceeding in an anteroposterior direction. The pathological anatomy of the mass was compatible with hepatocellular carcinoma with a solid-trabecular growth pattern and clear cell features. The heterogeneous pattern of neoplastic differentiation was indicative of a hepatocarcinoma developed on a previous adenoma.

Discussion
This case illustrates the challenges that can arise in the diagnosis of hepatocarcinoma. A correct definition and analysis of all the available elements are essential in planning the surgical treatment of liver tumors.
EFFECTIVE POROSITY OF 3D PRINTED SURGICAL MESHES
Authors: Galván Chacón V , Patrocinio Caballero D , Pagador Carrasco B , Duarte León M , Sánchez Margallo F 
Published: January 2023

Abstract

Introduction
According to previous studies, pore size and geometry are crucial factors to assure good clinical results for surgical meshes [refs]. Although commercial surgical meshes are commonly knitted, 3D printing has recently been used to provide additional properties to them [refs]. In general, the mechanical properties of 3D printed meshes are worse, but geometrical control is better than in knitted ones. In this study, a comparison of effective porosity between knitted and 3D printed surgical meshes was performed.

Methods
Pore size and geometry were characterized through optical brightfield microscopy (Nikon E100) and quantified using ImageJ v.1.53e. Several geometries of 3D printed meshes with polypropylene (Prusa i3 MK3 and Smartfil filament) and commercial polypropylene Assumesh meshes (Assut Europe) were evaluated. The 3D printed geometries were triangular and honeycomb while the commercial meshes were knitted.

Results
32.38, 18.65 and 17.26% of the total area of the commercial, triangular and honeycomb meshes were porous, respectively. Although effective porosity was homogeneous on commercial meshes (2.71±0.07 mm2), pore size was smaller in honeycomb (0.088±0.071 mm2) and bigger in triangular (0.201±0.063 mm2) than in commercial meshes (0.105±0.030 mm2).

Conclusions
Some imperfections are generated during the extrusion of filaments that contributes to non-uniform pores in 3D printed meshes. Hence, a post-processing of meshes will be recommended to take advantage of the higher precision of 3D printing.
ANTI-TUMORAL EFFECT OF 5-FLUOROURACIL AND OXALIPLATIN IN A LIVER REGENERATION MODEL
Authors: Novo Sukia I , Mendia Bravo M , Gil Rodríguez E , García-Alonso I , Ruiz Montesinos I , Herrero de la Parte B 
Published: January 2023

Abstract

Introduction
Colorectal cancer liver metastases (CRCLM) continue to be a therapeutic challenge, since their resectability is usually limited by the functionality of the liver remnant. In this context, it is necessary to study the regenerative response of the liver in a selective portal vein ligation (PVL) model, after the administration of 5-fluorouracil and oxaliplatin, and to assess the effect of compensatory hypertrophy on tumor progression.

Methods
Twenty-eight WAG/RijHsd rats carrying CRCLM were divided into four groups: control, PVL, 5FU (50mg/kg) and 5FU+Oxaliplatin (50mg/kg+10mg/kg). After 18 days of tumor development, a dose of the corresponding treatment was administered, performing a PVL of 50% 72h later. Seven days later, tumor size was quantified and a biochemical profile was performed.

Results
The 5FU+Oxaliplatin and 5FU alone treatment decreased tumor growth by 6 and 3 times compared to the PVL and control groups, respectively (p&lt;0.001). At a biochemical level, the combination of drugs resulted in a decrease in albumin levels (3.3 ± 0.39 mg/dl; p&lt;0.02) and a significant weight loss of 10%; however, glucose (152±6.6 mg/dl), AST (161±27.1 IU/L), and ALT (46.7±9.4 IU/L) were not significantly altered. Seven days after PVL, the liver remnant did not change in either group (5FU+Oxaliplatin: 8±1; 5FU: 9.7±1.2; control 9.4±1.9 g; p&gt;0.05).

Conclusion
In our model, the combined therapy of 5-Fluorouracil and oxaliplatin, prior to PVL, does not affect the necessary hepatic regeneration; while the volume of tumor implants decreases, no significant alteration of the biochemical parameters is detected.
DISGUISED INGUINAL HERNIA
Authors: López J , Bosch M , Lillo C , Barreras J A , Caravaca I , García P , Arroyo A , Lacueva J 
Published: January 2023

Abstract

Introduction
Liposarcomas are malignant neoplasms that originate in fatty mesenchymal tissue and are the most common histological subtype of soft tissue sarcomas. They account for 1% of solid tumors in adults and are located mainly in the extremities, with the retroperitoneum being the second most frequent location. Given the rarity and aggressiveness of these tumors, it is advisable to establish a multidisciplinary approach towards them in order to improve the prognosis of patients.

Clinical case
Patient who was operated upon on a scheduled and outpatient basis for a left inguinal hernia. During surgery, a preperitoneal tumor was identified that was removed and revealed a high-grade dedifferentiated liposarcoma. In a second surgical act, a tumor mass of about 10 centimeters in length was found, lodged in the left pelvis and contacting sigma, which extended into the inguinal duct and scrotal pouch. Finally, compartment surgery and a left orchiectomy with end-to-end colo-sigmoid anastomosis were performed.

Discussion
Routine examination of the masses contained in the hernial sacs is recommended since, despite their infrequency (&lt;0.1%), cases of liposarcomas that have their origin in the inguinal canal have been described. Surgery for retroperitoneal sarcomas must be compartmental, which requires the inclusion of viscera close to the tumor in the resection. Complete surgical resection R0 is the only potentially curative treatment. Compartment surgery should be performed by expert surgeons in referral centers with multidisciplinary teams to improve the prognosis of these patients.
NEW TECHNOLOGIES AT THE SERVICE OF THE PATIENT
Authors: Antuña Villa S , Mateos Palacios C , Soto Dopazo M , Arango Bravo A , Nuño Iglesias C , López-Mosquera Bayón E , Álvarez Iglesias B E , Fernández Fernández J C 
Published: January 2023

Abstract

Introduction
In the surgical field, information about operations is traditionally written down in the informed consent form, which often uses technical language that is difficult for patients to understand. Even when accompanied by verbal explanations, patients only seem to retain between 20–60% of the details.
With the purpose of improving the effectiveness of communication with our patients during the surgical process, from the Day Surgery Unit of our hospital we have developed a protocol to provide an audio-visual aid to the information supplied.

Methods
Two explanatory videos were developed for inguinal hernia repair and pilonidal cyst surgery, which were given to the patients under the care of our service using a QR code, both in the preoperative consultation and at discharge. The videos included simple explanations regarding the disease, procedure and postoperative care, in terms easily understandable to the general population. Subsequently, during postoperative follow-ups, feedback from the first 105 patients was collected.

Results
Results showed that, out of the first 105 patients who received the QR code, 72 watched the video, and of those, 100% were satisfied with the quality of the information provided and recognised that it improved their understanding of the procedure.

Conclusions
The use of new technologies, and, more specifically, of audio-visual support, could help to improve the comprehension of information received throughout surgical procedures, since it enables its repeated viewing and its sharing with relatives, which could improve the patient's overall satisfaction.
MICRO-RNA DETECTION FOR THE DIAGNOSIS OF COLON CANCER IN A MURINE MODEL
Authors: Bote J , Moreno-Lobato B , López-Nieto E , Sánchez-Margallo F M 
Published: January 2023

Abstract

Introduction
The main objective of this study was to characterise an animal model of colon cancer in the F344-ApcPircUwm rat through the analysis of microRNAs expressed in plasma by Next Generation Sequencing.

Methods
Colonoscopic follow-ups of the colon cancer model were performed for 10 months (n=60). At each follow-up, 2 ml of whole blood was collected in EDTA tubes, centrifuged for plasma extraction and frozen at - 80 °C. After euthanasia of the animals the different regions of the colon and their respective findings were analysed by histopathological analysis to obtain a ground truth. After this, 14 plasma samples were analysed by Next Generation Sequencing to observe the different expressions of microRNAs between the animals corresponding to the Neoplasia group and the healthy animals (n=6/8).

Results
After the corresponding functional analysis of the microRNAs deregulated in the animals of the colonic adenoma group and the healthy animals, we highlight rno-miR-192–5p, rno-miR-125b-5p and rno-miR-29c-3p, which appear underexpressed in the animals with adenomatous and adenocarcinomatous lesions in the colon.

Conclusions
The microRNAs deregulated in this animal model compared to their healthy counterpart without lesions obtained by liquid biopsy are miR-125b-5p, miR-192–5p and miR-29c-3p and their study could open the door to novel therapeutic strategies for prognosis and diagnosis by studying their expression in animal models that could be transferred to humans in the fight against colon cancer.
Socio-emotional adjustment in children attending family centres: The role of the parent–child relationship
Authors: Calatrava Maria , Swords Lorraine , Spratt Trevor 
Published: January 2023

Abstract
Family services offer the possibility of producing data sets, capable of primary analyses to measure service efficacy, and secondary analyses to develop nuanced understandings of family needs. In this article, we report secondary analysis of data drawn from 1,151 families elicited upon intake to family centres in Ireland. The aim was to examine correlates of children’s socio-emotional functioning, with focus on the quality of relationships between children and parents. Participating families completed surveys containing socio-demographic questions and standardised instruments tapping into children’s social, emotional and behavioural strengths and difficulties, parents’ mental health, and closeness and conflict in parent–child relationship. Findings indicated that parents’ perceptions of their children’s socio-emotional functioning significantly influenced the quality of the child–parent relationship. Higher levels of conflict were significantly associated with psychological difficulties, whilst greater closeness was significantly related to prosocial behaviours. These relationships held after controlling for a range of child, parent and family socio-demographic variables, such as the child’s experience of chronic illness or stressful life events, both of which independently predicted poorer outcomes. Results are discussed in terms of the dynamic, reciprocal nature of family relationships whereby parent–child conflict and children’s problematic socio-emotional functioning likely influence, and are influenced by, each other.
Ap4b1-knockout mouse model of hereditary spastic paraplegia type 47 displays motor dysfunction, aberrant brain morphology and ATG9A mislocalization
Authors: Scarrott Joseph M , Alves-Cruzeiro João , Marchi Paolo M , Webster Christopher P , Yang Zih-Liang , Karyka Evangelia , Marroccella Raffaele , Coldicott Ian , Thomas Hannah , Azzouz Mimoun 
Published: January 2023

AbstractMutations in any one of the four subunits (ɛ4, β4, μ4 and σ4) comprising the adaptor protein Complex 4 results in a complex form of hereditary spastic paraplegia, often termed adaptor protein Complex 4 deficiency syndrome. Deficits in adaptor protein Complex 4 complex function have been shown to disrupt intracellular trafficking, resulting in a broad phenotypic spectrum encompassing severe intellectual disability and progressive spastic paraplegia of the lower limbs in patients. Here we report the presence of neuropathological hallmarks of adaptor protein Complex 4 deficiency syndrome in a clustered regularly interspaced short palindromic repeats-mediated Ap4b1-knockout mouse model. Mice lacking the β4 subunit, and therefore lacking functional adaptor protein Complex 4, have a thin corpus callosum, enlarged lateral ventricles, motor co-ordination deficits, hyperactivity, a hindlimb clasping phenotype associated with neurodegeneration, and an abnormal gait. Analysis of autophagy-related protein 9A (a known cargo of the adaptor protein Complex 4 in these mice shows both upregulation of autophagy-related protein 9A protein levels across multiple tissues, as well as a striking mislocalization of autophagy-related protein 9A from a generalized cytoplasmic distribution to a marked accumulation in the trans-Golgi network within cells. This mislocalization is present in mature animals but is also in E15.5 embryonic cortical neurons. Histological examination of brain regions also shows an accumulation of calbindin-positive spheroid aggregates in the deep cerebellar nuclei of adaptor protein Complex 4-deficient mice, at the site of Purkinje cell axonal projections. Taken together, these findings show a definitive link between loss-of-function mutations in murine Ap4b1 and the development of symptoms consistent with adaptor protein Complex 4 deficiency disease in humans. Furthermore, this study provides strong evidence for the use of this model for further research into the aetiology of adaptor protein Complex 4 deficiency in humans, as well as its use for the development and testing of new therapeutic modalities.
Skin testing might have a diagnostic role in immune complex-mediated hypersensitivity reactions
Authors: Triwatcharikorn Jidapa , Pholmoo Natthiya , Ratanasutiranont Narumol , Rerknimitr Pawinee , Klaewsongkram Jettanong 
Published: January 2023

AbstractClinical applications of skin testing are known to help diagnose IgE-mediated and T-cell-mediated delayed cutaneous reactions. By contrast, drug-induced immune complex-mediated vasculitis is primarily diagnosed based on medical history, clinical setting and laboratory evidence of immune-complex formation, as there are no proven methods to identify the suspect culprit. We report three cases of drug- or biologic-induced immune complex-mediated vasculitis, in which the culprit agents could be confirmed by a positive intradermal test with later reading (between 12 and 24 h after the test), with verification by immunohistochemical or immunofluorescent results. The findings of our study suggest that skin tests with a delayed reading could have a potential role in diagnosing some instances of immune complex-mediated hypersensitivity reactions.
#corticophobia: a review on online misinformation related to topical steroids
Authors: Finnegan Paula , Murphy Michelle , O’Connor Cathal 
Published: January 2023

Abstract
Misinformation in healthcare is at crisis level worldwide, with the internet as primary source of prevarication. Topical corticosteroids (TCS) are a safe and effective treatment used in multiple dermatological conditions. Nonadherence to prescribed TCS can be due to phobia secondary to misinformation. TCS phobia is a complex multifaceted phenomenon that exploits patients with skin disease, creates cognitive dissonance and can obstruct successful treatment. This study aimed to examine the content of TCS-related misinformation available online. A formal review of PubMed was performed using the terms ‘topical corticosteroids’ AND ‘misinformation’ OR ‘disinformation’ OR ‘conspiracy theory, along with an informal Google search using combinations of these terms and further targeted searches on social media applications including Facebook™, Twitter™, Instagram™ and TikTok™. ‘Topical steroid withdrawal’, ‘red skin syndrome’ or ‘TCS addiction’ is a particularly prevalent myth currently being propagated on social media, with most content suggesting that eczema is due to a ‘leaky gut’ or food intolerance and not to skin inflammation. The risks of potential adverse effects such as skin thinning and stunted growth/development are often exaggerated. Multiple websites promoting misinformation were frequently endorsed by companies advertising consultations or testing to identify ‘underlying causes’, or ‘natural’ products as alternative treatments, including ‘herbal’ remedies, which can contain significant quantities of corticosteroids or other potent ingredients. The dermatology community should be vigilant of the type of TCS-related misinformation online and be active in attempts to counteract it with evidence-based advice.
Liver fibrosis for the dermatologist: a review
Authors: Raahimi Mina M , Livesey Amy , Hamilton Jessica , Shipman Alexa R , Aspinall Richard J 
Published: January 2023

Abstract
Methotrexate-induced liver fibrosis is not a well-defined pathology, and many of the reported cases can instead be classified as nonalcoholic fatty liver disease by current diagnostic criteria, which is particularly common in the psoriasis cohort. Liver fibrosis usually takes many years to progress; therefore, screening for liver fibrosis should be done no more regularly than annually at the very most in dermatology practice. An algorithm is presented about how to investigate abnormal liver blood tests and screening tools for liver fibrosis are compared.
Detection of FIP1L1–PDGFRA fusion gene-positive cells in the skin lesion of a patient with hypereosinophilic syndrome
Authors: Kitayama Shohei , Makino Teruhiko , Yoto Ayumi , Mori Shuichi , Furukawa Fumina , Torai Ryotaro , Mizawa Megumi , Shimizu Tadamichi 
Published: January 2023

Abstract
Hypereosinophilic syndrome (HES) is a heterogeneous group of diseases, characterized by persistent hypereosinophilia and end-organ damage. The FIP1L1–PDGFRA (F/P) fusion gene is found in 3–25% of patients with HES and is an oncogenic driver of myeloid neoplasms with clonal eosinophilia. Although cutaneous symptoms are the most common type of symptom in patients who have F/P fusion gene-positive HES (F/P HES), histological reports are limited. We herein present the case of a 78-year-old man with erythematous macules and severe pruritus on his trunk and extremities. Laboratory investigations revealed marked eosinophilia and elevated serum vitamin B12. A histological examination showed massive infiltration of eosinophils and mast cells around the vessels in the upper dermis. Fluorescence in situ hybridization revealed F/P fusion genes in nuclei in the peripheral blood and the skin lesion. The patient was diagnosed with F/P HES, and showed an excellent clinical and haematological response to imatinib.
Recommendation to update the British Society for Cutaneous Allergy corticosteroid series
Authors: Morrow Sarah E , Arianayagam Sanju , Wilkinson Mark , Bourke John , Bertram Chandra Gooptu , Buckley Deirdre A , Chowdhury Mahbub M U , Divekar Preshita , Ghaffar Sharizan Abdul , Green Cathy , Holden Catherine , Johnston Graham A , Mughal Avad , Dhonncha Eilis Nic , Reckling Christine , Scharrer Krisztina , Stone Natalie , Thompson Donna , Wakelin Sarah , Cooper Susan 
Published: January 2023

AbstractBackgroundPatch testing is an important investigation when dermatitis is unresponsive to, or worsened by, topical corticosteroid treatment. There is a balance to be struck between testing too many allergens, which is expensive, time consuming and risks causing sensitization, and testing too few, which risks missing the diagnosis. The current British Society for Cutaneous Allergy (BSCA) corticosteroid series comprises eight allergens and was last updated in February 2007.AimTo review and update the BSCA corticosteroid series.MethodsWe retrospectively analysed data from 16 patch test centres in the UK and Ireland for all patients who were patch tested to a corticosteroid series between August 2017 and July 2019. We recorded the allergens tested, the number and percentage tested to a corticosteroid series and the number of positive results for each allergen. We identified the allergens that test positive in ≥ 0.1% of selectively tested patients.ResultsOverall, 3531 patients were tested to a corticosteroid series in the 16 centres. The number of allergens tested ranged from 7 to 18 (mean 10). The proportion of patch test patients who were tested to a corticosteroid series ranged from 1% to 99%. Six allergens in the 2017 BSCA series tested positive in ≥ 0.1% of patients. Nine allergens not in the BSCA corticosteroid series tested positive in ≥ 0.1% of patients.ConclusionThis audit demonstrates the importance of regular review of recommended series and the significant variations in practice. The new BSCA corticosteroid series that we recommend contains 13 haptens, with the addition of the patient’s own steroid creams as appropriate.