bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher D‐dimer and activated partial thromboplastin time are poor prognostic factors in patients with peritoneal dialysis‐related peritonitis
Authors: Huang Ya‐Juan , Xiong Li‐Ping , Zhang Xing , Zhou Jia‐Fan , Zhang Rui 
Published: June 2023

AbstractIntroductionCoagulation system dysfunction is associated with adverse outcomes of peritoneal dialysis (PD) and bacterial infection. We investigated the association between coagulation system and treatment failure of peritoneal dialysis‐related peritonitis (PDRP).MethodsWe collected records of patients aged ≥18 years with PDRP. PDRP episodes were divided into: shortened activated partial thromboplastin time (APTT) group and prolonged APTT group, low D‐dimer (DD) group and high DD group. The baseline characteristics of the groups were collected and compared. The association between APTT, DD and treatment failure of PDRP was analyzed using logistic regression analysis.ResultsThirty episodes of treatment failure were observed in 110 episodes of PDRP in our study. After adjusting for variables, prolonged APTT (OR = 1.166 [1.049–1.296], p = 0.004) or high level of DD (OR = 1.374 [1.057–1.787], p = 0.017) was associated with treatment failure of PDRP.ConclusionProlonged baseline APTT or high level of DD increased the risk of treatment failure of PDRP.
Reduction of class I histone deacetylases ameliorates ER‐mitochondria cross‐talk in Alzheimer's disease
Authors: Marinho Daniela , Ferreira Ildete Luísa , Lorenzoni Ricardo , Cardoso Sandra M. , Santana Isabel , Rego A. Cristina 
Published: June 2023

AbstractSeveral molecular mechanisms have been described in Alzheimer's disease (AD), including repressed gene transcription and mitochondrial and endoplasmic reticulum (ER) dysfunction. In this study, we evaluate the potential efficacy of transcriptional modifications exerted by inhibition or knockdown of class I histone deacetylases (HDACs) in ameliorating ER‐mitochondria cross‐talk in AD models. Data show increased HDAC3 protein levels and decreased acetyl‐H3 in AD human cortex, and increased HDAC2‐3 in MCI peripheral human cells, HT22 mouse hippocampal cells exposed to Aβ1–42 oligomers (AβO) and APP/PS1 mouse hippocampus. Tacedinaline (Tac, a selective class I HDAC inhibitor) counteracted the increase in ER‐Ca2+ retention and mitochondrial Ca2+ accumulation, mitochondrial depolarization and impaired ER‐mitochondria cross‐talk, as observed in 3xTg‐AD mouse hippocampal neurons and AβO‐exposed HT22 cells. We further demonstrated diminished mRNA levels of proteins involved in mitochondrial‐associated ER membranes (MAM) in cells exposed to AβO upon Tac treatment, along with reduction in ER‐mitochondria contacts (MERCS) length. HDAC2 silencing reduced ER‐mitochondria Ca2+ transfer and mitochondrial Ca2+ retention, while knockdown of HDAC3 decreased ER‐Ca2+ accumulation in AβO‐treated cells. APP/PS1 mice treated with Tac (30 mg/kg/day) also showed regulation of mRNA levels of MAM‐related proteins, and reduced Aβ levels. These data demonstrate that Tac normalizes Ca2+ signaling between mitochondria and ER, involving the tethering between the two organelles in AD hippocampal neural cells. Tac‐mediated AD amelioration occurs through the regulation of protein expression at MAM, as observed in AD cells and animal models. Data support transcriptional regulation of ER‐mitochondria communication as a promising target for innovative therapeutics in AD.
Acyl coenzyme A binding protein (ACBP): An aging‐ and disease‐relevant “autophagy checkpoint”
Authors: Montégut Léa , Abdellatif Mahmoud , Motiño Omar , Madeo Frank , Martins Isabelle , Quesada Victor , López‐Otín Carlos , Kroemer Guido 
Published: June 2023

AbstractAcyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI), is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic radiation. In several eukaryotic phyla, ACBP/DBI transcends its intracellular function in fatty acid metabolism because it can be released into the extracellular space. This ACBP/DBI secretion usually occurs in response to nutrient scarcity through an autophagy‐dependent pathway. ACBP/DBI and its peptide fragments then act on a range of distinct receptors that diverge among phyla, namely metabotropic G protein‐coupled receptor in yeast (and likely in the mammalian central nervous system), a histidine receptor kinase in slime molds, and ionotropic gamma‐aminobutyric acid (GABA)A receptors in mammals. Genetic or antibody‐mediated inhibition of ACBP/DBI orthologs interferes with nutrient stress‐induced adaptations such as sporulation or increased food intake in multiple species, as it enhances lifespan or healthspan in yeast, plant leaves, nematodes, and multiple mouse models. These lifespan and healthspan‐extending effects of ACBP/DBI suppression are coupled to the induction of autophagy. Altogether, it appears that neutralization of extracellular ACBP/DBI results in “autophagy checkpoint inhibition” to unleash the anti‐aging potential of autophagy. Of note, in humans, ACBP/DBI levels increase in various tissues, as well as in the plasma, in the context of aging, obesity, uncontrolled infection or cardiovascular, inflammatory, neurodegenerative, and malignant diseases.
Conservation intensification under risk: An assessment of adoption, additionality, and farmer preferences
Authors: Canales Elizabeth , Bergtold Jason S. , Williams Jeffery R. 
Published: June 2023

AbstractConservation practices used on agricultural cropland can provide important ecosystem services. The United States relies largely on voluntary programs to incentivize adoption of conservation practices, but the success of these efforts relies on good program design. We use a choice experiment to evaluate farmers' willingness to adopt more intensive in‐field conservation practices (continuous no‐till, conservation crop rotation, cover crops, and variable rate application of inputs) using a nonlinear extended expected utility framework that incorporates risk under a conservation contract. We contribute to the literature by providing insights regarding producers' preference for incentive payment mechanism (federal program or carbon market) and the incentive payment needed to induce additionality and practice continuity. We find that although an additional payment might be needed to promote practice continuity among farmers who have previously adopted cover crops, in the case of continuous no‐till, adopters might be willing to forgo additional payment to continue benefiting from the use of this practice. Our results also revealed producers prefer conservation contracts accruing higher off‐farm environmental benefits and federally administered over carbon market programs. This is an important result given an increased public interest in climate change and new proposed carbon mitigation policies and private carbon market initiatives.
Factors beyond diagnosis and treatment that are associated with return to work in Australian cancer survivors—A systematic review
Authors: Forbes Danielle , Lisy Karolina , Wood Colin , White Victoria , Evans Sue , Afshar Nina , Ristevski Eli , Sharma Arun , Changrani Krisha , Jefford Michael 
Published: June 2023

AbstractReturn to work (RTW) is a marker of functional recovery for working‐age cancer survivors. Identifying factors that impact on RTW in cancer survivors is an essential step to guide further research and interventions to support RTW. This systematic review aimed to identify nontreatment, non‐cancer‐related variables impacting RTW in Australian cancer survivors. A systematic search was conducted in EMBASE, PsycINFO, CINAHL, PubMed, and Google Scholar. Studies were eligible if they included: (1) adults living post diagnosis of malignancy; (2) quantitative data for nontreatment, non‐cancer‐related variables impacting RTW; (3) only Australian participants. Included studies were critically appraised, and relevant data extracted and synthesized narratively. Six studies were included in the review, published between 2008 and 2020. Studies were of variable quality and mixed methodologies. One study included malignancies of any type with the remainder focusing on survivors of colorectal cancer (n = 3), oropharyngeal cancer (n = 1), and glioblastoma multiforme (n = 1). Multiple factors were related to RTW in individual studies, including older age, presence of three or more comorbidities, fewer work hours pre‐morbidly, lower body mass index, longer than recommended sleep duration, and not having private health insurance; however, there was limited consistency in findings between studies. Other variables examined included: occupation type, household income, healthy lifestyle behaviors, flexibility, and duration of employment with workplace; however, no significant associations with RTW were reported. Further research is required to gather compelling evidence on factors that influence RTW in Australian cancer survivors.
Potential impact of climate change on spatial distribution of two savannah amphibian species in West Africa
Authors: Ayoro Joëlle Halamoussa , Nicolas Violaine , Segniagbeto Gabriel Hoinsoudé , Hema Emmanuel Midibahaye , Ohler Annemarie , Kabré Gustave Boureima 
Published: June 2023

AbstractClimate change affects biodiversity, notably by modifying species habitats. In the West African savannahs, amphibian species are widespread. Despite their importance in ecosystems, little is known about the potential impacts of future climate change on these amphibians, hence the need to study the future distribution patterns of West African savannah amphibian species. We performed species distribution modelling to forecast the current and future distribution of two species Hyperolius nitidulus and Ptychadena bibroni in West Africa. Based on the global climate model MIROC5 and two future climate scenarios (RCP 4.5 and RCP 8.5), we assessed trends in the evolution of suitable habitat areas of these two amphibian species. We found that H. nitidulus is likely to lose significant proportions of their current habitats in the future due to climate change, while P. bibroni is likely to gain new suitable habitats. Our study suggests that some savannah amphibian species that are currently classified as Least Concern by the IUCN would be negatively affected by future climate change as shown by the distribution patterns of H. nitidulus. It is therefore necessary to consider all amphibian species, whether widely distributed or endemic, in future conservation strategies for amphibians in West Africa.
Does cooperative membership enhance inorganic fertilizer use intensity? Panel data evidence from maize farmers in Ethiopia
Authors: Geffersa Abebayehu Girma 
Published: June 2023

AbstractAgricultural cooperatives are increasingly being viewed as an effective means of promoting agricultural technologies in developing countries. This paper examines the effects of cooperative membership on inorganic fertilizer use intensity. Employing a three‐wave panel dataset relating to smallholder maize farmers in Ethiopia, we model inorganic fertilizer application as a two‐step decision‐making process involving both fertilizer adoption and its use intensity. To reflect these two related steps, we use a double‐hurdle model. We account for unobservable household heterogeneity and endogeneity utilizing a correlated random‐effects framework and a control function approach. The findings reveal that cooperative membership increased inorganic fertilizer use intensity, as well as the probability of it being used in the first place by 4.2% and 5.3%, respectively. Following further examination of who benefits most among cooperative members, we discovered that membership benefits all farmers in terms of fertilizer use intensity, irrespective of the members’ poverty status. However, we did not observe a significant effect of cooperative membership on the likelihood of fertilizer use by land‐poor and less asset‐endowed households. This highlights the necessity of implementing policies that provide poor and marginalized Ethiopian maize farmers with resources that enhance the contribution agricultural cooperatives make to their well‐being.
Survey content validation evaluating the dissemination and implementation of deprescribing guidelines
Authors: Cheng Chun Hei Justin , Langford Aili V. , Gnjidic Danijela , Farrell Barbara J. , Schneider Carl R. 
Published: June 2023

AbstractBackgroundPolicies, protocols and processes within organisations can facilitate or hinder guideline adoption. There is limited knowledge on the strategies used by organisations to disseminate and implement evidence‐based deprescribing guidelines or their impact.MethodsWe aimed to develop an online survey targeting key organisations involved in deprescribing guideline endorsement, dissemination, modification or translation internationally. Survey questions were drafted, mirroring the six components of the reach, effectiveness, adoption, implementation and maintenance (RE‐AIM) framework. Content validation was undertaken and established by a panel of clinicians, researchers and implementation experts.ResultsA 52‐item survey underwent two rounds of content validation. The minimum threshold (I‐CVI > 0.78) for relevance and importance was met for 39 items (75%) in the first round and 44 of 48 items (92%) in the second round. The expert panel concluded that the adoption, implementation and effectiveness survey sections were largely relevant and important to this topic, whereas the reach and maintenance sections were harder to understand and may be less pertinent to the research question.ConclusionsA 44‐item survey investigating dissemination and implementation strategies for deprescribing guidelines has been developed and its content validated. Widespread survey distribution may identify effective strategies and inform dissemination and implementation planning for newly developed guidelines.
Additional lesions identified by genomic microarrays are associated with an inferior outcome in low‐risk chronic lymphocytic leukaemia patients
Authors: Rigolin Gian Matteo , Traversa Alice , Caputo Viviana , Del Giudice Ilaria , Bardi Antonella , Saccenti Elena , Raponi Sara , Ilari Caterina , Cafforio Luciana , Giovannetti Agnese , Pizzuti Antonio , Guarini Anna , Foà Robin , Cuneo Antonio 
Published: June 2023

SummaryWe explored the relevance of genomic microarrays (GM) in the refinement of prognosis in newly diagnosed low‐risk chronic lymphocytic leukaemia (CLL) patients as defined by isolated del(13q) or no lesions by a standard 4 probe fluorescence in situ hybridization (FISH) analysis. Compared to FISH, additional lesions were detected by GM in 27 of the 119 patients (22.7%). The concordance rate between FISH and GM was 87.4%. Discordant results between cytogenetic banding analysis (CBA) and GM were observed in 45/119 cases (37.8%) and were mainly due to the intrinsic characteristics of each technique. The presence of additional lesions by GM was associated with age > 65 years (p = 0.047), advanced Binet stage (p = 0.001), CLL‐IPI score (p < 0.001), a complex karyotype (p = 0.004) and a worse time‐to‐first treatment in multivariate analysis (p = 0.009). Additional lesions by GM were also significantly associated with a worse time‐to‐first treatment in the subset of patients with wild‐type TP53 and mutated IGHV (p = 0.025). In CLL patients with low‐risk features, the presence of additional lesions identified by GM helps to identify a subset of patients with a worse outcome that could be proposed for a risk‐adapted follow‐up and for early treatment including targeted agents within clinical trials.
The role of legitimizing the social hierarchy in the impact of status on perceived assertiveness and competence
Authors: Louvet Eva , Ehrke Franziska , Gaubert Cécile , Tran H. Long 
Published: June 2023

AbstractThe present research aimed to examine how perceivers' system‐justifying beliefs moderate the way they evaluate high‐ versus low‐status targets on assertiveness and competence. In three experimental studies, we manipulated a target's hierarchical position within his company's organization. Participants rated the target on traits reflecting assertiveness and competence. Their system‐justifying beliefs were assessed in an ostensibly unrelated study. Results consistently showed that participants inferred assertiveness from the target's hierarchical position regardless of system justification, whereas the relationship between social status and competence was consistently moderated by system‐justifying beliefs: only participants high in system justification ascribed more competence to the high‐status target than to the low‐status target. These findings are in line with the hypothesis suggesting that inferring competence from high‐status positions could rely on the tendency to justify social inequalities, whereas inferring assertiveness would not.
Predicting bottom current deposition and erosion on the ocean floor
Authors: Beelen Daan , Wood Lesli J. 
Published: June 2023

AbstractMapping sediment deposition and erosion by thermohaline ocean bottom currents is important for the development of ocean infrastructure, future geo resources and understanding the sedimentology of contourites and abyssal sediment wavefields. However, only a limited percentage (estimated 20%) of the ocean floor has been mapped directly through seismic or sonar imaging. To better delineate where zones of bottom current deposition and erosion exist, we develop a prediction from numerical model solutions and sedimentological measurements of the ocean floor. This is achieved by integrating three types of data, which include the following: (1) bottom current shear stress from a model run of the HYCOM numerical ocean model; (2) sedimentation rates from ocean lithospheric age and sediment thickness from the GlobSed Model; (3) the measured extents of bottom current deposits from sonar observations. Shear stresses and sedimentation rates inside and outside the mapped extents of bottom current deposits allow us to quantify the conditions that are conducive for bottom current deposition. These conditions are then extrapolated and displayed on a 1/12° arcsecond resolution map of the world's oceans and validated through comparison with known, mapped systems. Based on our prediction, around 12% of the ocean has significant deposition by bottom currents while only 1% has erosion. Most bottom current activity occurs where thermohaline currents impinge upon the ocean floor like on continental slopes or some areas of the abyssal plain. Deposition and erosion also occur where constriction of ocean bottom currents takes place as in straits and seaways. Inland basins (i.e. seas) and continental shelves are mostly disconnected from global‐ocean thermohaline bottom current conveyors and, therefore, have limited bottom current deposition and erosion. Mid‐ocean ridges also have little bottom current deposition due to low sediment supply.
The extraordinary Namche Barwa sediment factory in the Eastern Himalayan Syntaxis
Authors: Dong Xiaolong , Hu Xiumian , Garzanti Eduardo , Liang Wendong , Li Guangwei , Lai Wen , Wang Chengshan , Han Zhongpeng , Deng Tao , Li Zhengchen 
Published: June 2023

AbstractThe Namche Barwa Syntaxis (NBS) is one of the most productive detrital factories on Earth. Previous studies have shown that the NBS supplies large amounts of sediment to the Brahmaputra River, although the sources and controlling factors of sediment production have not been ascertained in detail. This study presents petrographic and heavy‐mineral data for 43 sand samples collected in the Yarlung and Parlung river catchments covering the entire NBS and surrounding areas. Combined with U–Pb ages of detrital zircons, our data indicate that 89 ± 11% of Yarlung River sediments downstream of the NBS are produced in the Yarlung and Parlung gorges. The annual sediment flux of the Yarlung River increases by a factor of 20 within ca. 250 km from upstream of the NBS (ca. 10 Mt) to downstream (ca. 200 Mt/a). The Yarlung and Parlung gorges, representing only ca. 1% of the Yarlung‐Brahmaputra catchment area, contribute 74 ± 9% of the total Brahmaputra sediment flux. Average interannual erosion rates in the Yarlung and Parlung gorges corresponding to these fluxes are calculated to be 9.2 ± 1.2 mm/a and 6.5 ± 2.1 mm/a respectively. Focused erosion of the Namche Barwa Complex and Yarlung Suture Zone in the gorge, where high‐grade metamorphic rocks are exposed, is a consequence of high channel steepness (ksn values up to 800–1800), high stream power and extreme events including frequent earthquakes and landslides. The coupling between surface erosion and tectonic uplift in the Yarlung Gorge is in full agreement with the tectonic aneurism model of NBS evolution.
Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK‐dependent colorectal cancer
Authors: Shimizu Shota , Kondo Jumpei , Onuma Kunishige , Coppo Roberto , Ota Kasumi , Kamada Mayumi , Harada Yohei , Tanaka Yoshihisa , Nakazawa Mai Adachi , Tamada Yoshinori , Okuno Yasushi , Kawada Kenji , Obama Kazutaka , Coffey Robert J. , Fujiwara Yoshiyuki , Inoue Masahiro 
Published: June 2023

AbstractThe bone morphogenetic protein (BMP) pathway promotes differentiation and induces apoptosis in normal colorectal epithelial cells. However, its role in colorectal cancer (CRC) is controversial, where it can act as context‐dependent tumor promoter or tumor suppressor. Here we have found that CRC cells reside in a BMP‐rich environment based on curation of two publicly available RNA‐sequencing databases. Suppression of BMP using a specific BMP inhibitor, LDN193189, suppresses the growth of select CRC organoids. Colorectal cancer organoids treated with LDN193189 showed a decrease in epidermal growth factor receptor, which was mediated by protein degradation induced by leucine‐rich repeats and immunoglobulin‐like domains protein 1 (LRIG1) expression. Among 18 molecularly characterized CRC organoids, suppression of growth by BMP inhibition correlated with induction of LRIG1 gene expression. Notably, knockdown of LRIG1 in organoids diminished the growth‐suppressive effect of LDN193189. Furthermore, in CRC organoids, which are susceptible to growth suppression by LDN193189, simultaneous treatment with LDN193189 and trametinib, an FDA‐approved MEK inhibitor, resulted in cooperative growth inhibition both in vitro and in vivo. Taken together, the simultaneous inhibition of BMP and MEK could be a novel treatment option in CRC cases, and evaluating in vitro growth suppression and LRIG1 induction by BMP inhibition using patient‐derived organoids could offer functional biomarkers for predicting potential responders to this regimen.
Genetic and nongenetic mechanisms for colorectal cancer evolution
Authors: Kok Sau Yee , Nakayama Mizuho , Morita Atsuya , Oshima Hiroko , Oshima Masanobu 
Published: June 2023

AbstractThe stepwise accumulation of key driver mutations is responsible for the development and malignant progression of colorectal cancer in primary sites. Genetic mouse model studies have revealed combinations of driver gene mutations that induce phenotypic changes in tumors toward malignancy. However, cancer evolution is regulated by not only genetic alterations but also nongenetic mechanisms. For example, certain populations of metastatic cancer cells show a loss of malignant characteristics even after the accumulation of driver mutations, and such cells are eliminated in a negative selection manner. Furthermore, a polyclonal metastasis model has recently been proposed, in which cell clusters consisting of genetically heterogeneous cells break off from the primary site, disseminate to distant organs, and develop into heterogenous metastatic tumors. Such nongenetic mechanisms for malignant progression have been elucidated using genetically engineered mouse models as well as organoid transplantation experiments. In this review article, we discuss the role of genetic alterations in the malignant progression of primary intestinal tumors and nongenetic mechanisms for negative selection and polyclonal metastasis, which we learned from model studies.