bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crowdfunding and Sustainability of Watermills in the Himalayas: A Bibliometric Analysis
Authors: Dwivedi Prasoom , Joshi Shivam , Dwivedi Alka , Khanduri Aditi , Banerjee Sriparna 
Published: February 2023

Abstract
This study visualizes crowdfunding as a strategically important tool for the revival and survival of watermills in Uttarakhand. There are 500,000 watermills in the region from Afghanistan to Myanmar, between 100,000 to 200,000 in India, and 60,000 in Uttarakhand. These watermills have the potential to generate electricity up to 65000 MW at the rate of 2500 MW/hr that could be monetized at $ 17 million per hour in the northern mountain ranges. These watermills are also used for grinding purposes leading to multidimensional ways for sustainable livelihood. These watermills contribute to the social capital of the region immensely. The Government of India has supported these traditional knowledge-based activities by providing capital support and fiscal incentives. It is observed that despite the availability of government funds, the water mill owners lack finance for revenue expenditure, which is one of the significant barriers to the sustenance of water mills. Repair and maintenance of watermills, support to scale-up activities and other marketing activities, etc. are examples of recurring revenue expenditure. The goal of this descriptive paper broader view of the concept and evolution of crowdfunding based on a bibliometric tool. It analyses all crowdfunding-related publications in Scopus-indexed journals. It analyses the parameters number of papers published during 2011-2021based on various parameters. This study identifies the donation-based method as the least researched method of crowdfunding. It is also brought out that the donation-based method will not be useful in the case of repetitive crowdfunding initiatives.
Nutrient utilization strategies and age-related changes in larix principis-rupprechtii forests of different origins
Authors: Liu Tairui , Bo Fujing , Tan Zhijie , Hu Ruyuan , Ren Xuming , Wang pingan , Guo Jinping , Zhang Yunxiang , Wang Qiwu 
Published: February 2023

Abstract
Aims: Investigations into the nutrient content and changes in the stoichiometry and nutrient resorption strategies of different original forests during their development are of great significance toward the establishment of healthy, high-quality forest ecosystems.
Methods: 24 sample plots with age gradients were established in natural Larix principis-rupprechtii forests and plantations, from which mature and senescent leaves, new branches, fine roots, and soil were collected for analysis. The carbon (C), nitrogen (N), and phosphorus (P) contents were determined, and the stoichiometric ratios and resorption efficiencies were calculated.
Results and Conclusions: The soil organic carbon and total nitrogen of the forests accumulated with advancing age, while the total phosphorus decreased due to higher consumption. Plantation trees tended to store scarce nutrients within inactive plant structures to prevent nutrient loss, whereas natural forest trees maintained a stable nutrient concentration within their active organs. Plantation and natural forest trees adopted highly conservative N and P utilization strategies through improved resorption efficiencies. However, natural forest change was weaker than in plantations. The mature leaves, litter, branches, and fine roots of natural forestswere more susceptible to soil P concentrations, whereas those of their plantation counterparts were more affected by soil N. Nutrient concentrations within the active organs of plantation trees were more strongly dependent on soil than natural forests. We considered that natural forests likely possessed a more extensive range of strategies to deal with the variable compositions and concentrations of soil nutrients, which might strengthen their resilience against the effects of aging.
Metachronous Inflammatory Pseudotumor involving the Lung and the Brain: a case report
Authors: Xu Ze Bing , Deng Yan , Wang Huan , Tang Mengyue 
Published: February 2023

Abstract
Inflammatory pseudotumors (IPT) is a rare neoplasm and frequently involved in the lung during childhood. IPT metachronous or synchronize involves lung and brain is quite rare. Only five cases were reported in English literature and all of them were male children and adolescents, here we reported the sixth case in the middle-aged woman. The definitive diagnosis of the lesions depends on histopathology, which radiological appearance is easily mimic lung cancer combined with brain metastasis.
Identifying the characteristics of and factors driving spatiotemporal water quality variations in the Yellow River Basin, China, from 2008 to 2020
Authors: Liu Shasha , Qiu Yue , Fu Rui , Liu Yun , Suo Chengyu 
Published: February 2023

Abstract
The assessment of water quality has drawn much attention due to its implications in identifying pollution sources and enhancing living environments. We currently lack a systematic understanding of spatiotemporal water quality variations and their drivers in the Yellow River Basin. Therefore, we investigated the spatial and temporal fluctuations in water parameters and the possible factors driving these changes in the watershed. Rescaled range analysis, Pearson correlation test, and a generalized linear model were employed. Over the last 13 years, the permanganate index (CODMn) and ammonia nitrogen (NH3-N) have declined at rates of 0.26 and 0.18 (mg L-1) year-1, respectively, whereas the dissolved oxygen has increased at a rate of 0.19 (mg L-1) year-1. The effective control of CODMn (94.27%) and NH3-N (96.30%) is vital to reduce pollutant discharge and increase ecological protection and restoration. Geographically, the middle reaches had poor water quality and showed a significant positive correlation between NH3-N and coal reservation ( r = 0.89; P < 0.05). The total nitrogen concentrations followed increasing spatiotemporal trends, which may be indicative of the deterioration of major water quality parameters in the near future. Our findings offer insights into the spatiotemporal variations in water quality and the factors driving these changes in the Yellow River Basin. These results can help establish theoretical references for water quality protection and management.
Prevalence of respiratory pathogens in COVID patients
Authors: MICHEL Johnny , STOICA Maria-Alexandra , AOUITI-TRABELSI Myriam , DE OLIVEIRA Fabienne , HONG Eva , JOLY Luc-Marie , DEGHMANE Ala-Eddine , PLANTIER Jean-Christophe , TAHA Muhamed-Kheir 
Published: February 2023

Abstract
Background: Management of a novel respiratory virus causing severe pneumonitis included the use of antibiotics to prevent bacterial co-infections and secondary infections. However, the impact of this antibiotic use on the selection of resistant bacterial isolates needs to be evaluated.
Methods: We conducted a single-center retrospective study from November 14, 2020 to December 31, 2021 to assess the prevalence of several members of the nasopharyngeal microbiota from PCR-positive SARS-CoV-2 subjects. The study population corresponded to 1030 nasopharyngeal swabs positive for SARS-CoV-2 at the university hospital of Rouen site in symptomatic patients aged 16 years and older. Real-time PCR was used to detect the presence of Haemophilus influenzae, Streptococcus pneumonia, Neisseria meningitidis and influenza A virus. An analysis of the ftsI gene was further used to analyze beta-lactam resistance in H. influenzae.
Results: The results reveled less than expected carriage rate with 5% for H. influenzae, 1.2% for N. meningitidisand 3.7% for S. pneumoniae and an absence of influenza A. On the other hand, there was a significant difference (p<0.01) between the "carriage" and "no carriage" groups on age, sex, oxygen therapy and orotracheal intubation, implying a more severe evolution of the COVID-19 in carriers. Analysis of the ftsI gene reveals 26% of predicted resistance to amoxicillin without resistance to third generation cephalosporins.
Conclusions: COVID-19 pandemic has disrupted bacterial and viral epidemiology, leading to lower circulation of several respiratory pathogens.
Facile hermetic TEM grid preparation for molecular imaging of hydrated biological samples at room temperature
Authors: Ren Gang (Gary) , Kong Lingli , Liu Jianfang , Zhang Meng , Lu Zhuoyang , Xue Han , Ren Amy , Liu Jiankang , Li Jinping , Ling Wai Li 
Published: February 2023

Abstract
Although structures of vitrified supramolecular complexes have been determined at near-atomic resolution, elucidating in situ molecular structure in living cells remains a major challenge. Here, we apply a novel but simple liquid-cell technique, developed previously for real-time imaging of the dynamics at a liquid-gas interface, to image wet biological samples. With extra scattering from the liquid phase, the transmission electron micrographs show amplitude contrast comparable to that in negatively stained samples. Single-molecule domains are resolved in the protein complex GroEL imaged in buffer solution at room temperature. Moreover, various stages of virus cell entry, which are transient events with very few structural information to date, are also captured. Morphological details are reconstructed using the technique of individual particle electron tomography. These results demonstrate that this approach can be a valuable yet cost-effective technique complementary to other microscopy techniques for addressing important biological questions at the molecular level.
Dose optimization of silicon for boosting Arbuscular Mycorrhizal fungi colonization and cadmium stress mitigation in maize (Zea mays L.)
Authors: Zia Ubaid Ullah , Niazi Abdul Rehman , Ahmad Zahoor , Alharby Hesham F. , Waraich Ejaz Ahmad , Abbasi Asim , Iqbal Muhammad Aamir , Ahmed Sarfraz , Hina Shozab 
Published: February 2023

Abstract
The foliar applied Silicon (Si) has potential to ameliorate heavy metals especially cadmimum (Cd) toxicity, however Si dose optimization is strategically important for boosting growth of soil microbes and Cd stress mitigation.. Thus, the current research was performed to assess the Si induced physiochemical and antioxidant traits alterations along with Mycorrhizal (VAM) status in maize roots under Cd stress.The trial included foliar Si application at the rate of 0, 5, 10, 15, and 20 ppm while Cd stress was induced after full germination. The response variables included various physiochemical traits such as leaf pigments, protein and sugar contents etc. along with VAM alterations under induced Cd stress. The results revealed that foliage applied Si in higher dose remained effective in improving the leaf pigments,proline, soluble sugar, total proteins, and all free amino acids. Additionally, the same treatment remained unmatched in terms of antioxidant activity compared to lower doses of foliar applied Si.Moreover, VAM was recorded to be at peak under 20 ppm Si treatment. Thus, these encouraging findings may serve as baseline to develop Si foliar application as biologically viable mitigation strategy for maize grown in Cd toxic soils, future studies must test more doses with respect to to varying Cd stress levels along with determining the most responsive crop stage for Si foliar application.
GANT61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma
Authors: Yifeng Sun , Fang Qiongxuan , Liu Wei , Liu Yi , Zhang Chunming 
Published: February 2023

Abstract
Chondrosarcoma is ineffective for conventional radiotherapy and chemotherapy with a poor prognosis. Hedgehog (Hh) signal pathway plays a crucial role in tumor growth and progression, which is constitutive activated in chondrosarcoma. GLI transcription factors as targets for new drugs or interference technology for the treatment of chondrosarcoma are of great significance. In this study, we indicated that the Hedgehog-GLI1 signal pathway is activated in chondrosarcoma, which further enhances the RNAP III signal pathway to mediate endogenous tRNA fragments synthesis. Downstream oncology functions of endogenous tRNA fragments, such as “cell cycle” and “death receptor binding”, are involved in malignant chondrosarcoma. The GANT61, as an inhibitor of GLI1, could inhibit chondrosarcoma tumor growth effectively by inhibiting the RNAP III signal pathway and tRNA-Gly-CCC synthesis in vivo. Induced G2/M cell cycle resting, apoptosis and autophagy were the main mechanisms for the inhibitory effect of GANT61 on chondrosarcoma, which correspond with the above-described downstream oncology functions of endogenous tRNA fragments. We also identified the molecular mechanism by which GANT61-induced autophagy is involved in ULK1 expression and MAPK signaling pathway. Thus, GANT61 will be an ideal and promising strategy for combating chondrosarcoma.
Analysis of the relationship between plasma carnitine levels and non-valvular atrial fibrillation
Authors: Jiang Zong-dian , Zhao Yun-fei , Yang Dong-hui , Sun Jing-yi 
Published: February 2023

Abstract
Objective
To investigate the correlation between plasma carnitine levels and atrial fibrillation and its predictive value in atrial fibrillation by analyzing the changes of plasma carnitine levels in patients with atrial fibrillation (AF) by metabolomics methods.
Methods
The clinical data of consecutive patients with non-valvular atrial fibrillation admitted to the Second Hospital of Dalian Medical University from January 2020 to January 2022 and patients with sinus rhythm admitted for other reasons during the same period were collected, and the relationship between plasma carnitine levels and atrial fibrillation was investigated by analyzing the general clinical characteristics (including age, sex, blood pressure, blood lipids, body mass index, history of smoking, history of alcohol consumption, blood uric acid, left atrial internal diameter, history of hypertension, history of cerebral infarction, history of coronary artery disease) and laboratory test results such as plasma carnitine levels in both groups.
Results
In our study, a total of 195 patients were included in this study, including 90 patients in the atrial fibrillation group (including 45 patients with paroxysmal atrial fibrillation and 45 patients with persistent atrial fibrillation) and 105 patients in the sinus rhythm group. The plasma free carnitine CO, acetyl carnitine C2, propionyl carnitine C3, butyryl carnitine C4, isovaleryl carnitine C5, hydroxyisovaleryl carnitine C5-OH, palmitoyl carnitine C16, octadecanoyl carnitine C18, and 26-carbonyl carnitine C26 were significantly higher in the atrial fibrillation group than in the sinus rhythm group, and the differences were statistically significant (P < 0.05). The plasma acetylcarnitine C2, hydroxybutyrylcarnitine C4-OH, palmitoylcarnitine C16, and hydroxypalmitoylcarnitine C16:1-OH levels were significantly higher in the persistent AF group than in the paroxysmal AF group, and the differences were statistically significant (P < 0.05). Binary logistic regression analysis revealed that age, high-density lipoprotein, left atrial internal diameter, and free carnitine CO were independent risk factors for the development of atrial fibrillation.
Conclusion
Patients with atrial fibrillation have altered plasma levels of some carnitine, and the occurrence of atrial fibrillation may be related to disturbances in the metabolism of this part of carnitine. Free carnitine CO is an independent correlate of atrial fibrillation, and its elevated levels suggest that patients may be prone to atrial fibrillation.
Transfer of the high-temperature adult-plant stripe rust resistance gene Yr62 in four Chinese wheat cultivars
Authors: Zhou Jianian , Zheng Xiaochen , Tan Wenjing , Ma Chunhua , Tian Ran , Yan Qiong , Feng Junming , Zhang Liangqi , Jia Guoyun , Xia Chongjing , Yang Suizhuang , Kang Zhensheng , Chen Xianming , Li Xin , Zhou Xinli 
Published: February 2023

Abstract
Wheat stripe rust is one of the diseases that seriously affect wheat production worldwide. Breeding resistant cultivars is an effective measure to control this disease. The wheat stripe rust resistance gene Yr62 has high-temperature adult-plant resistance (HTAP). In this study, PI 660060, a single gene line containing Yr62, was crossed with four Chinese wheat cultivars, namely, LunXuan987 (LX987), Bainongaikang58 (AK58), ZhengMai9023 (ZM9023) and HanMai6172 (H6172). F1 seeds of four cross combinations were harvested and self-crossed in the field. Then 33 lines with good agronomic traits and high disease resistance were screened in the F9 generation. SSR markers Xgwm251 and Xgwm192 flank linked with the Yr62 were used to detect the presence of Yr62 in these 33 F9 lines. Among them, 22 lines successfully introduced the resistance gene Yr62 and evaluated the agronomic traits. Finally, nine lines with good agronomic traits and disease resistance were successfully selected. The wheat lines finally screened in this study provide material support for the future breeding of wheat for stripe rust resistance.
Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans
Authors: Wang Xueqing , Jiang Quanlong , Zhang Hongdao , He Zhidong , Song Yuanyuan , Chen Yifan , Tang Na , Zhou Yifei , Li Yiping , Antebi Adam , Wu Ligang , Han Jing-Dong , Shen Yidong 
Published: February 2023

Abstract
Ageing in various tissues exhibits common and distinct features. It is critical to decipher the mechanisms underlying ageing in individual tissues. MicroRNAs (miRNAs) are essential regulators in ageing and are recently highlighted as a new class of intercellular signalling molecules. However, little is known about the tissue-specific transcriptomic changes of miRNAs during ageing. C. elegans is a well-established model organism in ageing research. In this study, we isolated five major somatic tissues in young and aged worms and profiled the age-dependent miRNAomic changes within these tissues. In addition to the diverse ageing-regulated miRNA expression across tissues, we discovered numerous miRNAs in the tissues without their transcription. We further profiled miRNAs in the extracellular vesicles (EVs) and found that worm miRNAs undergo inter-tissue trafficking via EVs in an age-dependent manner. Using these datasets, we uncovered the interaction between mir-1 from body wall muscle and DAF-16/FOXO in the intestine, suggesting mir-1 as a messenger in inter-tissue signalling. Taken together, our study systematically investigated miRNAs in the somatic tissues and EVs during ageing, providing a valuable resource to study tissue-autonomous and nonautonomous functions of miRNAs in ageing.
Smart Monitoring System for Silkworm Incubator Using FPGA
Authors: R Mepco Schlenk Engineering College R Assistant Professor Kama , Seruvan D. Senthoor , Kumar K. R.Sathish 
Published: February 2023

Abstract
Sericulture is a growing business in modern world. As silk is consider as one of the richest crop, the demand for silk in world market is rising exponentially. Even though India is a largest consumer of silk but lag in production. China secures the first place in silk production. To nullify the growing demand for silk an automated system is introduced to increase the production of the silk using sensors and FPGA. Temperature, Humidity, light intensity plays major role in Sericulture. A Constant environmental parameters are needed to make silkworms alive .It is proved that a temperature of 27 °C to 28 °C is needed for silkworm to survive. For monitoring purpose humidity sensor (DHT11), gas sensor (MQ5), LDR sensor, temperature sensor(LM35) are used, to monitor environmental parameters of the incubator. SPARTAN 3E is used as a controller to operate cooler and light according to the sensor reading changes. To predict the health conditions of the silkworm, an enhanced Image processing algorithms has been used.
Variation of Soil Gas 222rn/220rn Concentration Ratios Along the Pinarbaşi Segment of Izmi̇r Fault
Authors: Masruoğlu Gülse , ALTUN Ceren , ŞENTÜRK Muhammed Zeki , İçhedef Mutlu , TAŞKÖPRÜ Caner 
Published: February 2023

Abstract
Measurements of 222Rn and 220Rn activity were carried out along the Pınarbaşı segment of the Izmir fault (IF) to get new information on the Izmir Fault (IF) and its seismicity. İzmir Fault is one of the most important active tectonic structures in Turkey's Active Fault Map. Due to very intense urbanization, there is not enough information about the fault. This study also discusses the usability of the 222Rn/220Rn ratio as a geodynamic precursor.
How to Annotate Patient Monitoring Alarms in Intensive Care Medicine for Machine Learning
Authors: Klopfenstein Sophie Anne Inès , Flint Anne Rike , Heeren Patrick , Prendke Mona , Chaoui Amin , Ocker Thomas , Chromik Jonas , Arnrich Bert , Balzer Felix , Poncette Akira-Sebastian 
Published: February 2023

Abstract
Alarm fatigue, a multi-factorial desensitization of personnel toward alarms, can harm both patients and healthcare staff in intensive care units (ICU). False and non-actionable alarms contribute to this condition. With an increasing number of alarms and more patient data being routinely collected and documented in ICUs, machine learning could help reduce alarm fatigue. As data annotation is complex and resource intensive, we propose a rule-based annotation method combining alarm and patient data to classify alarms as either actionable or non-actionable. This study presents the development of the annotation method and provides resources that were generated during the process, such as mappings.
The Relationship of Fibrinogen to Albumin Ratio with the Presence and Severity of Sepsis in Neonates
Authors: Dong Geng , Ma Tingting , Xu Zhe , Zhang Min , Hu Yidi , Yang Junmei , Li Tiewei 
Published: February 2023

AbstractPurpose Previous studies have shown that fibrinogen and albumin are closely related to sepsis. However, the role of fibrinogen (FIB) to albumin (ALB) ratio (FAR) in sepsis was still unclear, especially in neonates. Thus, this study is aimed at investigating whether FAR could independently predict the presence and severity of sepsis in neonates. Methods In this paper, clinical and laboratory data of 1292 neonates were retrospectively collected and divided them into three groups according to clinical diagnosis: control group (n = 555), mild sepsis group (n = 312), and severe sepsis group (n = 425). Neonates with sepsis were further divided into mild sepsis and severe sepsis group according to the severity of sepsis. All statistical analyses were performed using the statistical package SPSS 26.0, as appropriate. Results FAR levels were higher in neonates with sepsis. The prevalence of neonates with overall sepsis, mild sepsis and severe sepsis increased significantly from FAR tertile 1 to tertile 3. Multiple logistic regression analysis showed that FAR was an independent risk factor for the presence of sepsis (OR = 8.641, 95% CI 5.708–13.080, P < 0.001) and severe sepsis (OR = 2.817, 95% CI 1.701–4.666, P < 0.001). ROC curve analysis showed that FAR had a well discriminatory power in predicting sepsis (AUC = 0.67,95% CI 0.64–0.70, P < 0.001) and severe sepsis (AUC = 0.60, 95% CI, 0.57–0.64, P = 0.018). Conclusion In the current study, we demonstrated that FAR was an independent predictor for the presence and severity of neonatal sepsis.