bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy of Human Papillomavirus Vaccination as an Adjuvant Therapy in Recurrent Respiratory Papillomatosis
Authors: Ponduri Anusha , Azmy Monica C. , Axler Eden , Lin Juan , Schwartz Rachel , Chirilă Magdalena , Dikkers Frederik G. , Yang Christina J. , Mehta Vikas , Gangar Mona 
Published: January 2023

ObjectiveTo characterize the efficacy of human papillomavirus (HPV) vaccination as an adjuvant therapy in recurrent respiratory papillomatosis (RRP).Data SourcesPubMed, Embase, Cochrane, Google Scholar, ClinicalTrials.gov, and Web of Science databases were queried for articles published before April 2021.Review MethodsAll retrieved studies (n = 870) were independently analyzed by two reviewers according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) statement using predefined inclusion and exclusion criteria. 13 studies met inclusion criteria. A random‐effects meta‐analysis was performed to study intersurgical interval (ISI) and number of surgical procedures per year before and after vaccination.ResultsThe systematic review included 13 studies, comprising 243 patients. All studies utilized the Gardasil® quadrivalent vaccine, and one study (Yiu et al. 2019) utilized both the quadrivalent and Gardasil® 9‐valent vaccines. Our meta‐analysis included 62 patients with ISI data across 4 studies, and 111 patients with data on the number of surgical procedures per month across 7 studies. The mean number of surgical procedures decreased by 4.43 per year after vaccination (95% CI, −7.48 to −1.37). Mean ISI increased after vaccination, with a mean difference of 15.73 months (95% CI, 1.46–29.99). Two studies reported on HPV sero‐conversion, with HPV seropositivity of 100% prior to vaccination and 25.93% after vaccination.ConclusionThe addition of HPV vaccination was associated with an increase in time between surgeries and reduction in the number of surgical procedures required. HPV vaccination may be a beneficial adjuvant treatment for RRP.Level of EvidenceNA Laryngoscope, 133:2046–2054, 2023
Carolyn's Window Approach to Unilateral Frontal Sinus Surgery
Authors: Seresirikachorn Kachorn , Sit Andrea , Png Lu Hui , Kalish Larry , Campbell Raewyn G. , Alvarado Raquel , Harvey Richard J. 
Published: January 2023

ObjectivesDue to the complexity and variety of the frontal recess and sinus anatomy, traditional Draf 2a frontal sinus surgery is challenging. The thickness of the nasofrontal beak and anterior–posterior dimensions of the frontal recess contribute to this complexity. Carolyn's window technique eliminates the limitation of anterior–posterior depth to facilitate a Draf 2a frontal sinusotomy. The approach is a 0° endoscope technique and provides an excellent view of the frontal sinus and recess. We describe Carolyn's window approach to frontal sinus surgery and the perioperative outcomes.MethodsConsecutive adult patients in whom Carolyn's window technique was applied for frontal sinus dissection as part of the endoscopic management of both inflammatory and neoplastic disease were assessed. The primary outcome was frontal sinus patency. Secondary outcomes were surgical morbidity, defined as early (<90 days) or late (>90 days).ResultsForty‐five patients (49.1 ± 17.9 years, 48.9% Female) were assessed. All patients had successful frontal sinus patency (100% [95CI: 92.1%–100%]). Morbidities were adhesion (4.8%), crusting (2.4%), pain (1.2%), and bleeding (1.2%) in the early postoperative period. There were no other morbidities in the early and late postoperative periods.ConclusionCarolyn's window approach to frontal sinusotomy is a technique that evolves from previously described approaches. Successful frontal sinus patency with very low morbidities is achieved while still working with a 0° endoscope. The “axillectomy” performed simplifies frontal recess surgery by removing the anteroposterior diameter limitation and the dexterity required in angled endoscopy and instrumentation. The inferior‐based lateral wall mucosal flap and free mucosal grafting expedite the mucosal healing process. Laryngoscope, 133:2496–2501, 2023
Evaluation of Mobile and Digital Single‐Lens Reflex Photography for Facial Surgical Analysis
Authors: Deot Neal , Kiprovski Aleksandar , Hatala Adam , Obayemi Ade , Suryadevara Amar , Davila Richard O. 
Published: January 2023

ObjectivesHigh‐quality perioperative photography is imperative to good surgical planning in facial reconstructive and aesthetic surgery. We explore the utility of an add‐on smartphone telephoto lens to avoid the distortions noted in prior studies using smartphone cameras.MethodsStandard perioperative photographs of the same subject were taken with three distinct cameras using a dual‐ring light setup. The three camera setups iPhone 11 alone, iPhone 11 with the 58 Moment telephoto lens attachment, and a D3300 Nikon DSLR APS‐C sensor camera with a 60 mm NIKKOR F2.8G ED macro lens were compared using a 47‐question online survey consisting of demographic and image‐specific questions sent to plastic surgeons.ResultsForty‐nine facial plastic surgeons completed the survey. The iPhone 11 alone was identified as having the lowest quality for central/peripheral distortion (83%), columella/caudal septum/alar anatomy (58.3%), and skin quality (38.3%). With the addition of the telephoto lens, the ability to assess all categories was significantly improved. 53.1% (n = 26) of respondents found the iPhone 11 + 58 mm telephoto lens setup to be the most useful for perioperative surgical planning.ConclusionsSmartphone photography with the addition of a telephoto lens can offer a comparable option to the DSLR with regard to photo quality and detail.SummaryA telephoto add‐on lens is an effective solution to overcome the central distortion seen in images taken by the iPhone for perioperative photography. This photo quality was found to be comparable to that of traditional DSLR cameras in our survey study.Level of Evidence3 Laryngoscope, 133:2590–2596, 2023
Non‐contrast estimate of blood–brain barrier permeability in humans using arterial spin labeling and magnetization transfer at 7 T
Authors: Mahmud Sultan Z. , Denney Thomas S. , Bashir Adil 
Published: January 2023

AbstractBlood–brain barrier (BBB) dysfunction is associated with a number of central nervous system diseases. This study demonstrates the application of a novel noninvasive technique to measure the BBB permeability in the human brain at 7 T. The technique exploits the fact that, when tissue macromolecules are saturated by off‐resonance RF pulse, the intravascular and the extravascular (tissue) water experience different magnetization transfer effects. This principle was combined with arterial spin labeling to distinguish between the intravascular and the tissue water, and was used to calculate perfusion, water extraction fraction (E), and BBB permeability surface area product for water (PS). Simultaneous coregistered magnetization transfer ratio maps were also generated that can provide valuable additional information. Eighteen healthy volunteers (seven females), age = 27 ± 11 years and weight = 65 ± 9 kg, participated in the study. Average perfusion was 67 ± 5 and 29 ± 4 ml/100 g/min (p < 0.05); and E was 0.921 ± 0.025 and 0.962 ± 0.015 (p < 0.05) in the gray matter (GM) and the white matter (WM), respectively. PS was higher in the GM (171 ± 20 ml/100 g/min) compared with the WM (95 ± 18 ml/100 g/min) (p < 0.05). The parameters exhibited good reliability with test re‐test experiments. The sensitivity of this technique was demonstrated by 200 mg caffeine intake, which resulted in a decrease in the resting PS by ~31%.
Persistent SARS‐CoV‐2 infection in patients seemingly recovered from COVID‐19
Authors: Bussani Rossana , Zentilin Lorena , Correa Ricardo , Colliva Andrea , Silvestri Furio , Zacchigna Serena , Collesi Chiara , Giacca Mauro 
Published: January 2023

AbstractSARS‐CoV‐2 infection is clinically heterogeneous, ranging from asymptomatic to deadly. A few patients with COVID‐19 appear to recover from acute viral infection but nevertheless progress in their disease and eventually die, despite persistent negativity at molecular tests for SARS‐CoV‐2 RNA. Here, we performed post‐mortem analyses in 27 consecutive patients who had apparently recovered from COVID‐19 but had progressively worsened in their clinical conditions despite repeated viral negativity in nasopharyngeal swabs or bronchioalveolar lavage for 11–300 consecutive days (average: 105.5 days). Three of these patients remained PCR‐negative for over 9 months. Post‐mortem analysis revealed evidence of diffuse or focal interstitial pneumonia in 23/27 (81%) patients, accompanied by extensive fibrotic substitution in 13 cases (47%). Despite apparent virological remission, lung pathology was similar to that observed in acute COVID‐19 individuals, including micro‐ and macro‐vascular thrombosis (67% of cases), vasculitis (24%), squamous metaplasia of the respiratory epithelium (30%), frequent cytological abnormalities and syncytia (67%), and the presence of dysmorphic features in the bronchial cartilage (44%). Consistent with molecular test negativity, SARS‐CoV‐2 antigens were not detected in the respiratory epithelium. In contrast, antibodies against both spike and nucleocapsid revealed the frequent (70%) infection of bronchial cartilage chondrocytes and para‐bronchial gland epithelial cells. In a few patients (19%), we also detected positivity in vascular pericytes and endothelial cells. Quantitative RT‐PCR amplification in tissue lysates confirmed the presence of viral RNA. Together, these findings indicate that SARS‐CoV‐2 infection can persist significantly longer than suggested by standard PCR‐negative tests, with specific infection of specific cell types in the lung. Whether these persistently infected cells also play a pathogenic role in long COVID remains to be addressed. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Clinical evaluation of late outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER 2 study
Authors: Feijen Elizabeth A. M. , Teepen Jop C. , van Dulmen‐den Broeder Eline , van den Heuvel‐Eibrink Marry M. , van der Heiden‐van der Loo Margriet , van der Pal Helena J. H. , de Vries Andrica C. H. , Louwerens Marloes , Bresters Dorine , Versluys Birgitta , de Ridder Hanneke , Veening Margreet , van Leeuwen Flora E. , Grootenhuis Martha , Maurice‐Stam Heleen , van Santen Hanneke M. , Neggers Sebastian J. C. M. M. , Pluijm Saskia , den Hartogh Jaap , Ronckers Cécile M. , Tissing Wim J. E. , Loonen Jacqueline J. , Kremer Leontien C. M. 
Published: January 2023

AbstractBackgroundChildhood cancer survivors face late health problems; despite advances in research, details on risk remain unclear. We describe the methodological aspects of the Dutch Childhood Cancer Survivor Study (DCCSS) cross‐sectional clinical study (LATER 2 study).ProcedureFrom the multi‐center DCCSS LATER cohort of 6165 five‐year survivors diagnosed during 1963–2001, we invited 4735 eligible survivors in 2016, as well as siblings and parents of survivors. Gaps in evidence identified during development of surveillance guidelines were translated into clinical research questions for 16 outcome‐specific subprojects. The regular care visit to the LATER outpatient clinic forms the backbone of outcome assessment complemented with research‐defined measurements (physical examination, clinical tests, questionnaires). Furthermore, blood/saliva samples were taken for deoxyribonucleic acid (DNA) extraction.ResultsIn total, 2519 (53.2%) survivors participated in the LATER 2 study. When comparing participants with nonparticipants, we observed that males, CNS survivors, and those treated with surgery only were less likely to participate. Of the participating survivors, 49.3% were female. Median time since childhood cancer diagnosis was 26.9 years (range 14.8–54.7 years) and median attained age was 34.4 years (range 15.4–66.6 years).ConclusionsThe high‐quality data generated in the LATER 2 study will provide valuable insights into risks of and risk factors for clinical and physical and psychosocial health outcomes and factors for early recognition of those health outcomes in long‐term childhood cancer survivors. This will contribute to fill in important gaps in knowledge and improve the quality of life and care for childhood cancer survivors.
Response to sirolimus in capillary lymphatic venous malformations and associated syndromes: Impact on symptomatology, quality of life, and radiographic response
Authors: Engel Elissa R. , Hammill Adrienne , Adams Denise , Phillips Roderic J. , Jeng Michael , Tollefson Megha M. , Iacobas Ionela , Schiff Deborah , Greenberger Shoshana , Kelly Michael , Frieden Ilona , Zaghloul Nibal , Drolet Beth , Geddis Amy , Goldenberg Dov , Ricci Kiersten 
Published: January 2023

AbstractBackgroundCapillary lymphatic venous malformations (CLVM) and associated syndromes, including Klippel–Trenaunay syndrome (KTS) and congenital lipomatous overgrowth, vascular malformation, epidermal nevi, skeletal, and spinal syndrome (CLOVES), are underrecognized disorders associated with high morbidity from chronic pain, recurrent infections, bleeding, and clotting complications. The rarity of these disorders and heterogeneity of clinical presentations make large‐scale randomized clinical drug trials challenging. Identification of PIK3CA (phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha [gene]) mutations in CLVM has made targeted medications, such as sirolimus, attractive treatment options. The aim of this study was to investigate the safety and efficacy of sirolimus therapy in CLVM.ProcedureA combined prospective and retrospective cohort of pediatric and young adult patients with CLVM treated with sirolimus was evaluated for disease response, including symptom improvement, quality of life (QOL), and radiologic response. Sirolimus dosing regimens and toxicities were also assessed.ResultsTwenty‐nine patients with CLVM, including KTS and CLOVES, were included. Ninety‐three percent of patients reported improved QOL, and 86% had improvement in at least one symptom. Most significantly, improvement was noted in 100% of patients with bleeding and 89% with thrombotic complications with corresponding decreases in mean D‐dimer (p = .008) and increases in mean fibrinogen (p = .016). No patients had progressive disease on sirolimus. Most common side effects included neutropenia, lymphopenia, infection, and aphthous ulcers/stomatitis. No toxicities were life‐threatening, and none required long‐term discontinuation of sirolimus.ConclusionSirolimus appears to be effective at reducing complications and improving QOL in patients with CLVM and associated syndromes. In this patient cohort, sirolimus was well tolerated and resulted in few treatment‐related toxicities.
Sustainable intensification with irrigation raises farm profit despite climate emergency
Authors: Muleke Albert , Harrison Matthew Tom , Eisner Rowan , de Voil Peter , Yanotti Maria , Liu Ke , Monjardino Marta , Yin Xiaogang , Wang Weilu , Nie Jiangwen , Ferreira Carla , Zhao Jin , Zhang Feng , Fahad Shah , Shurpali Narasinha , Feng Puyu , Zhang Yunbo , Forster Daniel , Yang Rui , Qi Zhiming , Fei Wang , Gao Xionghui , Man Jianguo , Nie Lixiao 
Published: January 2023

Societal Impact StatementDespite comprising a small proportion of global agricultural land use, irrigated agriculture is enormously important to the global agricultural economy. Burgeoning food demand driven by population growth—together with reduced food supply caused by the climate crisis—is polarising the existing tension between water used for agricultural production versus that required for environmental conservation. We show that sustainable intensification via more diverse crop rotations, more efficient water application infrastructure and greater farm area under irrigation is conducive to greater farm business profitability under future climates.Summary

Research aimed at improving crop productivity often does not account for the complexity of real farms underpinned by land‐use changes in space and time.
Here, we demonstrate how a new framework—WaterCan Profit—can be used to elicit such complexity using an irrigated case study farm with four whole‐farm adaptation scenarios (Baseline, Diversified, Intensified and Simplified) with four types of irrigated infrastructure (Gravity, Pipe & Riser, Pivot and Drip).
Without adaptation, the climate crisis detrimentally impacted on farm profitability due to the combination of increased evaporative demand and increased drought frequency. Whole‐farm intensification—via greater irrigated land use, incorporation of rice, cotton and maize and increased nitrogen fertiliser application—was the only adaptation capable of raising farm productivity under future climates. Diversification through incorporation of grain legumes into crop rotations significantly improved profitability under historical climates; however, profitability of this adaptation declined under future climates. Simplified systems reduced economic risk but also had lower long‐term economic returns.
We conclude with four key insights: (1) When assessing whole‐farm profit, metrics matter: Diversified systems generally had higher profitability than Intensified systems per unit water, but not per unit land area; (2) gravity‐based irrigation infrastructure required the most water, followed by sprinkler systems, whereas Drip irrigation used the least water; (3) whole‐farm agronomic adaptation through management and crop genotype had greater impact on productivity compared with changes in irrigation infrastructure; and (4) only whole‐farm intensification was able to raise profitability under future climates.
Global output feedback control for large‐scale time‐delay systems with inherent nonlinearities and measurement uncertainty
Authors: Yu Weiyong , Sun Guocheng , Guo Qianjin , Liu Qiang 
Published: January 2023

AbstractThis paper investigates the problem of global state regulation by output feedback for a class of large‐scale nonlinear time‐delay systems with inherent nonlinearities and unknown measurement sensitivity. The uncertain nonlinearities are bounded by nonlinear growth of lower triangular unmeasurable (delayed) states multiplied by the unknown constant, polynomial‐of‐output and polynomial‐of‐input. Different from closely related works, the simultaneous existence of complicated nonlinearities and unknown measurement sensitivity makes the problem more involved and complex. Based on the dynamic gain scaling technique, we design a set of new adaptive output feedback controllers with a simpler structure by constructing two Lyapunov–Krasovskii functionals appropriately, which can globally regulate all states of the large‐scale systems. An illustrative example is proposed to demonstrate the validity of the presented control scheme.
Synthesis of in situ Generated Cu−CNT Hybrid Nanofluid and the Study of Their Thermo‐physical Properties
Authors: Gupta Nikita , Gupta Shipra Mital , Sharma S. K. 
Published: January 2023

AbstractIn recent years, numerous investigations have been carried out in heat transfer applications for CNT nanofluid as it possesses a high thermal conductivity compared to conventional fluids. Hydrophobicity of CNT poses a challenge to disperse CNT in polar basefluid. Surfactants can solve this issue up to a certain extent only but have some associated disadvantages such as foam formation, stickiness and viscosity enhancement responsible for an increase in power required to pump Nanofluid in heat transfer devices. This work presents preparation of a hybrid nanofluid as an alternative. Cu−CNT hybrid nanoparticles were generated in this research using in‐situ preparation of Cu nanoparticles in the presence of CNT and dispersion in double distilled water without addition of surfactant to produce a stable nanofluid. FESEM with EDX confirms copper nanoparticles present on outer surface of MWCNT and Raman spectroscopy confirmed the covalent functionalization. Spectral analysis, Zeta potential, and DLS were used to evaluate the dispersibility of Cu−CNT hybrid nanofluid. The results showed that the samples were extremely stable, with maximum stability of about 168 days. XRD pattern of Cu−CNT hybrid nanoparticles confirmed the existence of Cu and CNT. Nanofluid demonstrated a minor increase in density and viscosity compared to basefluid water due to addition of nanoparticles. An increase in thermal conductivity was also observed, which is critical for heat transfer applications.
Rational Design, Synthesis, Docking Simulation, and ADMET Prediction of Novel Barbituric‐hydrazine‐phenoxy‐1,2,3‐triazole‐acetamide Derivatives as Potent Urease Inhibitors
Authors: Hosseinzadeh Nouraddin , Nazari Montazer Mohammad , Mohammadi‐Khanaposhtani Maryam , Valizadeh Yousef , Amanlou Massoud , Mahdavi Mohammad 
Published: January 2023

AbstractUrease is an important target for the treatment of Helicobacter pylori infection. In this study, several pharmacophores for the inhibition of urease were considered and coupled to design new molecules capable of acting as potent urease inhibitors. Literature review reveals that barbituric‐hydrazine, phenoxy‐1,2,3‐triazole, and acetamide moieties are pharmacophores for urease inhibition. Therefore, in this study, the barbituric‐hydrazine‐phenoxy‐1,2,3‐triazole‐acetamide scaffold was designed and twelve derivatives 9 a–l of it were synthesized and evaluated. The urease inhibition assay of these compounds revealed that all new title compounds, except for one compound, with IC50 values of 0.73 to 5.27 μM were more potent than standard inhibitor thiourea. The most potent compound inhibited urease in a mixed‐type inhibition mode and interacted as well with the urease active site. In silico drug‐likeness and toxicity studies of the most potent compounds predicted that these compounds passed successfully Lipinski's rule of five and had no carcinogenicity on the rat.
Thiol Functionalized Aloe Vera Fibre Filter: A Simple Portable Water Filter For Heavy Metal Ion Removal
Authors: Ram Thimmiah Bhargavi , Nallathambi Gobi 
Published: January 2023

AbstractA novel high efficient filtration system for heavy metal ion adsorption from water bodies has been developed. It is a cost‐efficient filtration system that removes Pb2+ and Cd2+ ions effectively in an efficient manner. Aloe vera fibre that has been alkali‐treated and given a thiol functional is stuffed into a porous tube with a packing density of 0.2, and the porous tube is covered with polyacrylonitrile nanofibre. Functionalized aloe vera fibre and PAN nano fibres were characterized by various techniques such as X‐ray difractiomatry (XRD), Attenuated total reflection‐fourier transforms infrared spectroscopy (ATR‐FTIR), thermo gravimetric analysis (TGA), tensile tester and scanning electron microscopy (SEM). Furthermore, the heavy metal ion removal efficiency of filtration system was examined by inductively coupled plasma‐optical emission spectrometry (ICP‐OES). Inductively coupled plasma‐optical emission spectrometry (ICP‐OES) was used to evaluate the effectiveness of the filtering system‘s ability to remove heavy metal ions. In order to conduct column adsorption tests, the initial metal ion concentration was varied. The breakthrough curves of the trials were then analysed. With the aid of Thomas adsorption isotherm and Yoon‐Nelson model, the adsorption mechanism of thiol functionalized aloe vera fibre was thoroughly investigated. The portable filter has the ability to continuously treat waste water, which is a useful function.