bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion of innovations through social networks: Determinants and implications
Authors: Gondal Neha 
Published: March 2023

AbstractSocial scientists have long been interested in the diffusion of innovations—the process by which new ideas, behavior, and practices spread between persons, organizations, and even countries. While innovations can enter a community through various channels, ongoing spread of innovations through a community occurs through the medium of social networks—collections of interpersonal or digital relationships connecting actors to each other. Social networks are important for diffusion because relationships foster communication, trust, and flow of information. Diffusion outcomes are also shaped by the structural properties of social networks such as density, centrality, and strength of ties, as well as properties of the innovation and the actors involved in the process. The purpose of the article is twofold: (1) to take stock of the field and review ongoing debates on the role of social networks in the diffusion of innovations and (2) to summarize the sociological implications of the diffusion of innovations through social networks.
Chromosome‐level reference genome of Tetrastigma hemsleyanum (Vitaceae) provides insights into genomic evolution and the biosynthesis of phenylpropanoids and flavonoids
Authors: Zhu Shanshan , Zhang Xinyi , Ren Chaoqian , Xu Xinhan , Comes Hans Peter , Jiang Weimei , Fu Chengxin , Feng Huixia , Cai Liming , Hong Deyuan , Li Kunlun , Kai Guoyin , Qiu Yingxiong 
Published: March 2023

SUMMARYHere, we present a high‐quality chromosome‐scale genome assembly (2.19 Gb) and annotation of Tetrastigma hemsleyanum, a perennial herbaceous liana native to subtropical China with diverse medicinal applications. Approximately 73% of the genome was comprised of transposable elements (TEs), of which long terminal repeat retrotransposons (LTR‐RTs) were a predominant group (69% of the genome). The genome size increase of T. hemsleyanum (relative to Vitis species) was mostly due to the proliferation of LTR‐RTs. Of the different modes of gene duplication identified, transposed duplication (TRD) and dispersed duplication (DSD) were the predominant ones. Genes, particularly those involved in the phenylpropanoid–flavonoid (PF) pathway and those associated with therapeutic properties and environmental stress resistance, were significantly amplified through recent tandem duplications. We dated the divergence of two intraspecific lineages in Southwest (SW) versus Central‐South‐East (CSE) China to the late Miocene (approximately 5.2 million years ago). Of those, the former showed more upregulated genes and metabolites. Based on resequencing data of 38 individuals representing both lineages, we identified various candidate genes related to ‘response to stimulus’ and ‘biosynthetic process’, including ThFLS11, which is putatively involved in flavonoid accumulation. Overall, this study provides abundant genomic resources for future evolutionary, ecological, and functional genomics studies in T. hemsleyanum and related species.
Ultrasonographic Appearance of Gallbladder Neoplasia in 14 Dogs and 1 Cat
Authors: MacLeod Alexandra N. , Reichle Jean K. , Szabo David , Cohen Eli B. , Artiles Charles , Fulkerson Caroline V , Kurihara Manabu , Mattoon John 
Published: March 2023

AbstractUltrasonography is the most commonly used diagnostic imaging tool for gallbladder disease in veterinary medicine. Primary gallbladder neoplasia is an uncommon finding with variable prognosis for which no studies have been published describing their ultrasonographic appearance and diagnosis. This retrospective, multicenter, case series study examines the ultrasonographic appearance of gallbladder neoplasia with histologically or cytologically confirmed diagnoses. A total of 14 dogs and 1 cat were analyzed. All discrete masses were sessile in shape and varied in size, echogenicity, location, and gallbladder wall thickening. All studies with images showing Doppler interrogation exhibited vascularity. Cholecystoliths were an uncommon finding, being present in only one case in this study, unlike in humans. The final diagnosis of the gallbladder neoplasia was neuroendocrine carcinoma (8), leiomyoma (3), lymphoma (1), gastrointestinal stromal tumor (1), extrahepatic cholangiocellular carcinoma (1), and adenoma (1). Findings from this study indicate that primary gallbladder neoplasms have variable sonographic appearances and cytologic and histologic diagnoses.
On the end of evolution – Humankind and the annihilation of species
Authors: Glaubrecht Matthias 
Published: March 2023

AbstractFor too long and with ever‐increasing ferocity during the past decades of an exponentially growing human world population, humankind has been waging a genuine war against nature, of which we ourselves are nevertheless also a part. We are plundering the unique biological treasure, the diversity of species, without which the ecosystems we rely on for our food, our water and so much more would not function. At present, we are already in the midst of a massive decline of populations and species, with a significantly higher extinction rate than the long‐term average. Driven essentially by habitat loss and degradation, direct exploitation through legal and illegal hunting and fishing as well as pesticides and pollution, within decades, 1 million species out of a total of 8 million could go extinct. Alongside climate change, this dramatic decay of biodiversity, that involves also the subsequent loss of ecosystem services, here termed ‘the end of evolution’, is another and by no means lesser threat to humanity. We can still take countermeasures, but we must transform our economy and change our way of living. As most successful strategy the protection of up to 30% of Earth's surface by 2030 was suggested, ideally based on the implementation of a consistent framework of global ecosystems, as it was agreed on by the December 2022 United Nations Conference of Parties (COP15) Montreal meeting for the Conservation on Biological Diversity.
Offshore Logistics: Scenario Planning and Installation Modeling of Floating Offshore Wind Projects
Authors: Torres Esperanza Susana , Thies Philipp R. , Lawless Mark 
Published: March 2023

AbstractThe offshore installation, logistics, and commissioning activities are currently estimated to make up 20% to 30% of the capital expenditures (CAPEX) of offshore wind projects. Technical and geographical factors affect both the CAPEX during construction and the installation schedule, such as a lack of supporting port infrastructure, the availability of specialized vessels, the distance from the wind farm to shore, accessibility, water depths, and seabed conditions. In addition, there are significant risks during the construction phase, such as uncertain durations due to the sensitivity of marine operations to weather conditions. Identifying supply chain requirements is critical in the early stages of project planning in order to avoid time delays and cost overruns during the transport and installation process. This study explores and analyzes the logistic requirements and installation methods of a floating offshore wind (FOW) technology. Using an advanced forecasting and decision support tool, realistic case scenarios are simulated at a variety of potential sites for FOW deployment across the UK. Technical risks associated with installation strategies are identified and classified. The results provide a comparison of key installation performance indicators of each case scenario (e.g., installation rate per wind turbine, weather downtime). This study is of interest to researchers, offshore wind project developers, service providers, and other key stakeholders seeking to optimize planning and logistics to drive down CAPEX costs, reduce the construction downtime, and minimize risks during marine operations.
Flaw-insensitive fatigue resistance of chemically fixed collagenous soft tissues
Authors: Zeng Liangsong , Liu Fengkai , Yu Qifeng , Jin Chenyu , Yang Jian , Suo Zhigang , Tang Jingda 
Published: March 2023

Bovine pericardium (BP) has been used as leaflets of prosthetic heart valves. The leaflets are sutured on metallic stents and can survive 400 million flaps (~10-year life span), unaffected by the suture holes. This flaw-insensitive fatigue resistance is unmatched by synthetic leaflets. We show that the endurance strength of BP under cyclic stretch is insensitive to cuts as long as 1 centimeter, about two orders of magnitude longer than that of a thermoplastic polyurethane (TPU). The flaw-insensitive fatigue resistance of BP results from the high strength of collagen fibers and soft matrix between them. When BP is stretched, the soft matrix enables a collagen fiber to transmit tension over a long length. The energy in the long length dissipates when the fiber breaks. We demonstrate that a BP leaflet greatly outperforms a TPU leaflet. It is hoped that these findings will aid the development of soft materials for flaw-insensitive fatigue resistance.
A New Species of Golden Loach (genus Sabanejewia, Cobitidae) from the Sea of Azov Basin
Authors: Vasil’eva E. D. , Vasil’ev V. P. 
Published: March 2023

Abstract
A new species of golden loach is described from the Don River basin. This species is distinguished from all other Sabanejewia species by the following set of characters: a midlateral row of relatively large 9–16 (more often 13–14) dark blotches along flank usually well developed; no black line along flank; interspaces between midlateral blotches usually with dark pigmentation; some individuals with uniform dark lateral coloration; dorsal fin origin usually in front of pelvic fin origin; body relatively low: body depth noticeably less than the length of the caudal peduncle, usually does not reach 17% standard length—SL, it is contained more than 6 times in SL; dorsal adipose crest on caudal peduncle very weakly developed, ventral crest poorly visible; two black spots at caudal fin base usually merge with each other. Previously, this species was considered conspecific for S. baltica distributed in the Black and Baltic Sea basins, but recent phylogenetic studies have shown that they belong to separate mtDNA phylogenetic lineages.
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals
Authors: Lisano Jonathon K. , Kisiolek Jacob , Flores Victoria , Smoak Peter , Pullen Nicholas A. , Stewart Laura K. 
Published: March 2023

Introduction: This study evaluated depression, monocyte phenotype, and immune function in physically active cannabis users. Methods: Participants ( N = 23) were classified as either cannabis users (CU, n = 11) or non-users (NU, n = 12). White blood cells isolated from blood were analyzed for co-expression of cluster of differentiation 14 and 16 using flow cytometry. Lipopolysaccharide (LPS) was cultured with whole blood and assessed for interleukin-6 and tumor necrosis factor-α (TNF-α) release. Results: The percentage of white blood cells classified as monocytes was not different between groups; however, CU had a significantly greater percentage of monocytes classified as intermediate ( p = 0.02). When standardized per milliliter of blood, CU had significantly greater numbers of total monocytes ( p = 0.01), classical monocytes ( p = 0.02), and intermediate monocytes ( p = 0.01). Intermediate monocytes per milliliter of blood were positively correlated to the number of times CU used cannabis per day ( r = 0.864, p < 0.01) and Beck Depression Inventory-II (BDI-II) score ( r = 0.475, p = 0.03), which was significantly greater in CU (5.1 ± 4.8) compared with NU (0.8 ± 1.0; p < 0.01). CU released significantly less TNF-α per monocyte in response to LPS. Conclusions: CU had altered monocyte phenotypes and functions compared with NU. Elevations in intermediate monocytes were positively correlated with measures of cannabis use and BDI-II score.
Validation of wind measurements from a multirotor RPAS-mounted ultrasonic wind sensor using a ground-based LiDAR system
Authors: Scicluna Leo , Sant Tonio , Farrugia Robert N. 
Published: March 2023

The aim of this research was to establish the validity of wind measurements from on board a multirotor Remotely Piloted Aircraft System (RPAS) for the purposes of wind monitoring applications. A custom-built hexacopter RPAS recorded wind speed and direction by means of an onboard ultrasonic wind sensor, whilst operating in the inherently highly stochastic nature of open field atmospheric conditions. Experimental data were collected during open field hovering flights subject to different ambient conditions with free stream horizontal wind speeds reaching up to 12 m/s. Flights were conducted at different altitudes above ground level and in proximity to a Light Detection and Ranging (LiDAR) remote wind measurement unit that was used as a low-resolution reference meteorological station. Very good correlation was obtained between the RPAS and LiDAR unit for both wind speed and wind direction measurements across all hovering flight altitudes. The RPAS-based wind speed measurements were found to have a consistent 1 m/s positive offset, whilst the RPAS-based wind direction readings had a 6.16° negative offset. These were potentially caused by differences in the localized wind fields between the LiDAR and RPAS measuring positions, as well as by localized RPAS rotor-induced air flows for wind speed measurements and potential slight misalignments in the instruments’ reference datum for wind direction readings.
CCNE1andPLK1Mediate Resistance to Palbociclib in HR+/HER2− Metastatic Breast Cancer
Authors: Guerrero-Zotano Ángel , Belli Stefania , Zielinski Christoph , Gil-Gil Miguel , Fernandez-Serra Antonio , Ruiz-Borrego Manuel , Ciruelos Gil Eva Maria , Pascual Javier , Muñoz-Mateu Montserrat , Bermejo Begoña , Margeli Vila Mireia , Antón Antonio , Murillo Laura , Nissenbaum Bella , Liu Yuan , Herranz Jesús , Fernández-García Daniel , Caballero Rosalía , López-Guerrero José Antonio , Bianco Roberto , Formisano Luigi , Turner Nicholas , Martín Miguel 
Published: March 2023

AbstractPurpose:In hormone receptor–positive (HR+)/HER2− metastatic breast cancer (MBC), it is imperative to identify patients who respond poorly to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and to discover therapeutic targets to reverse this resistance. Non-luminal breast cancer subtype and high levels of CCNE1 are candidate biomarkers in this setting, but further validation is needed.Experimental Design:We performed mRNA gene expression profiling and correlation with progression-free survival (PFS) on 455 tumor samples included in the phase III PEARL study, which assigned patients with HR+/HER2− MBC to receive palbociclib+endocrine therapy (ET) versus capecitabine. Estrogen receptor–positive (ER+)/HER2− breast cancer cell lines were used to generate and characterize resistance to palbociclib+ET.Results:Non-luminal subtype was more prevalent in metastatic (14%) than in primary tumor samples (4%). Patients with non-luminal tumors had median PFS of 2.4 months with palbociclib+ET and 9.3 months with capecitabine; HR 4.16, adjusted P value &lt; 0.0001. Tumors with high CCNE1 expression (above median) also had worse median PFS with palbociclib+ET (6.2 months) than with capecitabine (9.3 months); HR 1.55, adjusted P value = 0.0036. In patients refractory to palbociclib+ET (PFS in the lower quartile), we found higher levels of Polo-like kinase 1 (PLK1). In an independent data set (PALOMA3), tumors with high PLK1 show worse median PFS than those with low PLK1 expression under palbociclib+ET treatment. In ER+/HER2− cell line models, we show that PLK1 inhibition reverses resistance to palbociclib+ET.Conclusions:We confirm the association of non-luminal subtype and CCNE1 with resistance to CDK4/6i+ET in HR+ MBC. High levels of PLK1 mRNA identify patients with poor response to palbociclib, suggesting PLK1 could also play a role in the setting of resistance to CDK4/6i.
Abstract ED11-1: Hormone receptor positive breast cancer
Authors: Ma Cynthia 
Published: March 2023

Abstract
Estrogen receptor (ER) positive breast cancer is a heterogeneous group of diseases. While the major goal of neoadjuvant treatment in patients with locally advanced disease is to downstage the cancer to facilitate resectability and breast-conserving surgery, there is increasing evidence that response in the neoadjuvant setting has prognostic implications in predicting long term relapse outcomes. However, questions remain as to strategies that optimize neoadjuvant treatment selection of endocrine therapy versus chemotherapy, and whether adjuvant therapy could be tailored based on treatment response in the neoadjuvant setting. In this lecture, we will discuss evolving data regarding pathologic and molecular characteristics of ER positive breast cancer that assist with treatment selection in the neoadjuvant setting and the potential role of pathologic and biomarker response to neoadjuvant endocrine therapy in tailoring adjuvant chemotherapy decisions.
Citation Format: Cynthia Ma. Hormone receptor positive breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr ED11-1.
Abstract ED6-2: RT: How short can it be
Authors: Krug David 
Published: March 2023

Abstract
Adjuvant whole-breast radiotherapy for breast cancer has traditionally been delivered over the course of 5 weeks. In the past decades, there has been a paradigm shift towards moderate hypofractionation with 15-16 fractions over 3 weeks based on randomized controlled trials demonstrating comparable oncological safety, decreased acute toxicity and similar long-term toxicity compared to conventional fractionation. More recently, ultra-hypofractionated whole-breast radiotherapy delivered with 5 fractions over 1 week or 5 weeks has been introduced into the clinic. Furthermore, the increasing use of partial-breast irradiation with a de-escalation of the target volume to the region of the lumpectomy cavity has further allowed acceleration of radiotherapy delivery for patients with breast cancer. This lecture will summarize recent advances and data on hypofractionation for breast cancer.
Citation Format: David Krug. RT: How short can it be [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr ED6-2.
Abstract F2-2: Neutrophil elastase and anti-tumor effects
Authors: Becker Lev 
Published: March 2023

Abstract
Cancer cell genetic variability and similarity to host cells have stymied development of broad anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse pathogens and limit host toxicity; however, whether/how innate immunity can produce similar effects in cancer is unknown. Here, we show that human, but not murine, neutrophils release catalytically active neutrophil elastase (ELANE) to kill many cancer cell types while sparing non-cancer cells. On a molecular level, ELANE proteolytically liberates the CD95 death domain, which interacts with histone H1 isoforms to selectively eradicate cancer cells. In pre-clinical models, ELANE attenuates primary tumor growth and produces a CD8+ T cell-mediated abscopal effect to attack distant metastases, therapeutic effects that are improved on by porcine pancreatic elastase, an ELANE homolog that better resists protease inhibitors in the tumor microenvironment. Altogether, our studies suggest that ELANE kills genetically diverse cancer cells with minimal toxicity to non-cancer cells, raising the possibility of developing it as a broad anti-cancer therapy.
Citation Format: Lev Becker. Neutrophil elastase and anti-tumor effects [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr F2-2.
Abstract P1-05-17: Radiomic models based on dynamic contrast-enhanced magnetic resonance imaging predict the immunophenotype reflecting spatial distribution of CD8+ tumor-infiltrating lymphocytes in breast cancer
Authors: Jeon Seung Hyuck , Kim So-Woon , Seo Mirinae , Lim Yu Jin 
Published: March 2023

Abstract
Purpose: This study aimed to develop noninvasive magnetic resonance imaging (MRI)-based radiomic models to predict immunophenotypes of breast cancer. Methods: A total of 182 breast cancer patients who underwent upfront surgery were analyzed, divided into training (n = 137) and validation (n = 45) cohorts. Dynamic contrast-enhanced (DCE)-MRI was acquired, and immunophenotype was determined on the surgical tumor sections: immune-inflamed (high degree of CD8+ T cells infiltrated), -excluded (CD8+ T cells accumulated at invasive margin but not efficiently infiltrated in tumor bed), and -desert (CD8+ T cells absent within tumor and at margins). Based on 833 radiomic features extracted after manual delineation, the least absolute shrinkage and selection operator method was used to build radiomic models. Results: Our radiomic models from the whole tumor sections showed moderate performance in predicting the immune-inflamed versus non-inflamed tumors, showing the highest AUC values, of 0.659 and 0.671 for training and validation cohorts, respectively. Combining the models, much improved predictability was observed, with AUC values of 0.973 and 0.985 for training and validation cohorts, respectively. Other radiomic features from tumor periphery data discriminated immune-excluded versus immune-desert status, with AUC values of 0.993 and 0.984 for training and validation cohorts, respectively. The combined models were also applicable to predicting immunophenotype for different molecular subtypes, with AUC values ≥ 0.867. Conclusions: By integrating the immunohistochemistry profiles, we established MRI-derived radiomic models to predict the detailed immunophenotype of breast cancer. This study suggests the feasibility of noninvasive assessment of tumor immune status in real-world clinics.
Citation Format: Seung Hyuck Jeon, So-Woon Kim, Mirinae Seo, Yu Jin Lim. Radiomic models based on dynamic contrast-enhanced magnetic resonance imaging predict the immunophenotype reflecting spatial distribution of CD8+ tumor-infiltrating lymphocytes in breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-05-17.