bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of stem cell therapy in patients with Diabetes Mellitus – A Systematic Review and Meta-analysis
Authors: Manikandan Srinivasan , Hariprasad Roopa , Bagepally Bhavani Shankara 
Published: January 2025

Abstract

Background
To support the development of a national guideline on stem cell therapy, the Department of Health Research, India, commissioned this systematic review to evaluate the efficacy and safety of various stem cell types in patients with type 1 and type 2 diabetes mellitus (DM), focusing on patient-important outcomes.
Methods
Following PRISMA guidelines, a literature search was conducted in PubMed, Embase, Web of Science, and Cochrane databases from inception to August 30, 2024. Critical outcomes for type 1 DM included insulin-free periods, hypoglycemic episodes, quality of life, and serious adverse events. For type 2 DM, outcomes included HbA1c, insulin requirements at 6, 12, and 24 months, and serious adverse events. Meta-analyses used random- or fixed-effects models based on heterogeneity (Chi-square test and I²). Risk of bias was assessed using Cochrane Risk of Bias Tool 2.0, and evidence certainty was evaluated with GRADE.
Results
The search identified 11,026 articles, of which 20 randomized controlled trials (RCTs) were included, encompassing 427 and 351 patients in the intervention and control groups, respectively, with follow-ups ranging from 3 to 96 months. Predominantly studied therapies included mesenchymal and bone marrow mononuclear stem cells. In type 1 DM, stem cell therapy showed no significant improvement in quality of life [MD: 3.15% (95% CI: -0.80 to 7.10), I² = 0%] or reduction in hypoglycemic episodes [RR: 0.90 (95% CI: 0.56 to 1.45), I² = 0%]. In type 2 DM, stem cell therapy significantly reduced insulin requirements at 6, 12, and 24 months, with MDs of -14.42 IU/day (95% CI: -24.25 to -4.59, I² = 91.64%), -17.79 IU/day (95% CI: -26.39 to -9.18, I² = 70.96%), and − 35.73 IU/day (95% CI: -40.82 to -30.64, I² = NA), respectively, with a low certainty of evidence.
Conclusion
Stem cell therapy did not achieve an insulin-free state or improved quality of life in type 1 DM patients. However, it reduced insulin requirements by 14–36 units over 6–24 months in type 2 DM patients, without significant glycemic control. Larger, high-quality RCTs with extended follow-ups are essential to determine the therapeutic potential of stem cell therapy in diabetes mellitus.
PROSPERO ID: CRD42023451602
In Vitro and In Vivo Germination of Novel F1 Hybrid Banana Calcutta 4 × Neypoovan Tetraploid Enhanced by Gibberellin and Indole-3-acetic acid
Authors: - Bhuvaneshwari - , Rex Gilbert Ross , - Ramajayam - , - Sivashankari - 
Published: January 2025

Abstract

This work focuses on rescuing and germinating embryos from F1 hybrid seeds obtained from the cross of Calcutta 4 and Neypoovan tetraploids. The goal was to assess the effects of growth regulators gibberellic acid (GA3) and indole-3-acetic acid (IAA) on seed germination and early seedling development in vitro and in vivo.The seeds were hydro-primed and surface-sterilized for 48 hours before being treated with different concentrations of GA3 (5 and 10 ppm) and IAA (5 and 10 ppm). The seeds were hydro-primed and surface-sterilized for 48 hours before being subjected to various concentrations of GA3 (5 and 10 ppm) and IAA (5 and 10 ppm). Embryo rescue was performed using Murashige and Skoog (MS) media for in vitro germination, with in vivo germination observed for comparison. The results showed that the maximum germination rate (77.78%) and better shoot and root growth were attained under in vitro conditions with GA3 at 5 ppm, with early shoot emergence at 8.40 days and shoot length reaching 6.63 mm. In vivo germination rates, however, were much lower, with just 6.67% germination in seeds treated with GA3 at 5 and 10 ppm and 0% in those treated with IAA. GA3 at 5 ppm was determined to be the best concentration for increasing germination and development of Calcutta 4 x Ney Poovan tetraploid hybrid seeds, especially in vitro.
Severe Central Airway Obstruction Secondary to a Endobronchial Central Airway Obstruction Secondary to Primary B-cell Lymphoma With : three case reports and literature review
Authors: LI Cai-li , ZHOU Wei , CHEN Mo , LI Shuo , CHEN Bao-yuan , WANG Yu-bao , ZHAO Hai-yan , FENG Jing 
Published: January 2025

Abstract

Central airway obstruction can be secondary to extrinsic compression from surrounding structures, direct extension from an adjacent tumor, metastatic disease and, less commonly primary intrinsic endobronchial malignancies.To our knowledge, nearly few reports of an isolated central airway lesion by primary lymphoma without extrathoracic or extra-nodal manifestation have been published to date. This is the first case about malignant trachea obstruction caused by primary B-cell lymphoma without involvement of the main stem bronchi, lobar bronchus and mediastinum. Cases presentation: The three patients were admitted to hospital for coughing accompanied by wheezing that recent exacerbated. The chest computed tomography scan revealed a soft tissue-density mass within the central trachea. Pathological analysis showed that these were lymphoma. No enlarged mediastinal or cervical lymph nodes were found.. Conclusion: A high suspicion of endobronchial lymphoma is warranted in the differential diagnosis of a pathological mass located in central airway.
Does bullying occur in preschool? A survey of French preschool workers’ perceptions and beliefs about bullying
Authors: Martelli Inès , Grand Estelle , Dewandre Antoinette , Habib Marianne , Villemonteix Thomas 
Published: January 2025

Abstract

School bullying constitutes a significant adverse childhood experience for both victims and perpetrators. Teachers and school staff play a pivotal role in identifying and preventing bullying. Although extensively studied among school-aged children, research on bullying in preschool settings remains scarce. This study used quant data to explore the perceptions and beliefs of French preschool staff (N = 191) regarding bullying, focusing on definitional aspects, observed bullying behaviors in preschool environments, the roles of school staff and parents, and beliefs about prevention. The findings reveal that French preschool staff's understanding of bullying definitions diverges somewhat from those commonly found in the scientific literature. Moreover, participants expressed hesitancy in applying the term "bullying" to describe aggressive interactions among preschool-aged children. The results further indicate that professional training for preschool staff could be enhanced to promote more effective interpersonal dynamics within teams. While participants emphasized the importance of implementing prevention programs in French preschools and actively engaging parents, they reported limited implementation of such initiatives. These findings align with existing literature but also highlight unique contextual factors shaped by French educational policies and anti-bullying legislation.
Insights into the Formation of Covalent Organic Frameworks by Probing Interfacial Water Structure using Vibrational Sum Frequency Generation Spectroscopy
Authors: Pandey Ravindra , Kumar Yogesh , Varanasi Srinivasa 
Published: January 2025

Abstract

Covalent organic frameworks (COFs) are an emerging class of porous materials with diverse applications across multiple fields. Most of the ongoing research related to COFs predominantly focuses on developing new materials through novel linkers and innovative reactions, as well as exploring their applications. A detailed molecular-level understanding of COF synthesis is essential for developing advanced materials. The water structure adjacent to COFs can significantly influence the design of highly efficient materials for heterogeneous catalysis, photocatalytic water splitting, and water purification, as well as aid in understanding the charge storage mechanism in COF-based electrodes at electrode/electrolyte interfaces. To address this issue, we synthesized a 2D COF thin film via photon-assisted imine condensation at the water-air interface and investigated the process using vibrational sum frequency generation (VSFG) spectroscopy. We examined the role of a catalyst, light, and interfacial water molecules in the synthesis of COF. VSFG spectroscopy is utilized to successfully distinguish between amorphous and crystalline thin films of COF on the water surface. Moreover, it was found that water exhibits increased ordering and stronger hydrogen bonding in proximity to COF interfaces.
Clinical efficacy of choledochoscopy using pancreaticobiliary imaging-guided catheter to diagnose and treat biliary pancreatitis via the cystic duct, common bile duct, and duodenum
Authors: Li Po , Cheng Jianrong , Hou Yiru , Cui Feifei , Chen Qian , Ma Ruirui , Sun Huiling , Wang Nan , Yao Jiaxi , Chen Xiaojun 
Published: January 2025

Abstract

This clinical study aimed to explore the clinical efficacy of performing a choledochoscopy with a 9FR disposable pancreaticobiliary imaging-guided catheter to diagnose and treat acute biliary pancreatitis caused by common bile duct stones. A retrospective analysis was conducted involving patients who underwent laparoscopy with a 9FR disposable pancreaticobiliary imaging-guided catheter. Endoscopy was conducted via the gallbladder duct, common bile duct, hepatopancreatic ampulla, duodenal papilla, and descending duodenal lumen between January 2020 and January 2024 at our institution. Clinical indicators were analyzed and postoperative treatment effects were monitored. Sixty-six patients underwent surgery, including fifty with secondary common bile duct stones and sixteen with primary common bile duct stones. The operative time ranged from 80 to 290 minutes ( 138.79 ± 36.86 minutes). Intraoperatively, blood loss ranged from 5 to 50 mL (13.03 ± 7.06 mL) and average postoperative lengths of hospital stays of 9.95 ± 2.43 days were recorded. All patients were followed up for 6 to 12 months. No pancreatitis, recurrence of common bile duct stones, bile fistulas, or stenosis of the common bile duct were observed. Abdominal ultrasound examination of the common bile duct and pancreas showed no abnormalities, and biochemical indicators were within normal ranges. Laparoscopy using a 9FR disposable pancreaticobiliary imaging-guided catheter through the gallbladder duct, common bile duct, hepatopancreatic ampulla, duodenal papilla, and descending duodenal cavity is beneficial for diagnosing and treating common bile duct microstones. The procedure can relieve biliary obstruction, curb further progression of acute biliary pancreatitis, accelerate the recovery process of postoperative gastrointestinal function, improve liver and pancreatic function in patients, and reduce the incidence of related complications. This technique is safe and feasible; however, the surgical difficulty is high. The operator must be skilled in laparoscopy and choledochoscopy, and minimally invasive surgical techniques. Cases must be strictly screened.
A Cloud-Edge Collaborative Model Training Framework for Assisted Classification of Middle Ear Diseases Based on Ultra-High-Resolution Temporal Bone CT ImagesAbstract
Authors: Wu Ting , Tang Yu , Che Zigang , Zhao Jiangjiang , Wang Jue , Wu Yanfeng , Meng Wei , He Shuangba 
Published: January 2025

Abstract

Objective: Cholesteatoma and otitis media are two of the most common middle ear diseases, of which the treatment principles are different, making the differentiation between them of significant importance. Both chronic suppurative otitis media (CSOM) and middle ear cholesteatoma (MEC) can appear on CT images as low-density soft tissue-like masses partially filling the middle ear and mastoid cavities. However, typical CT imaging of MEC may show progressive destruction of auditory structures and adjacent cranial bones. Compared to high-resolution CT (HRCT), ultra-high-resolution CT (U-HRCT) offers inherent continuity and a more detailed display of the fine structures of the middle ear. This study proposes a "cloud-edge" collaborative training framework for middle ear disease classification that exploits temporal bone U-HRCT imaging data. By integrating the YOLO recognition algorithm, this framework aims to achieve auxiliary classification of MEC and CSOM based on U-HRCT images.
Methods: In the cloud-edge collaborative framework, the edge devices acquire U-HRCT imaging data and perform auxiliary classification of middle ear diseases using image recognition and inference techniques. The imaging data collected by the edge devices are transmitted to the cloud, where a unified model training process is executed, and the model containers are then deployed to the edge devices for future auxiliary diagnosis. The framework employed Mixup and Mosaic methods for data augmentation to enhance model robustness and improve generalization performance. The object detection models of the You Only Look Once (YOLO) family was used, and the final model selection was made based on their performance.
Results: This study found that this cloud-edge collaborative framework can effectively classify temporal bone U-HRCT imaging data for MEC and CSOM. In the test set, the framework successfully collected real CT image data, performed data processing and conducted model training as designed. Eventually, multiple models were trained, with different levels of detection ability assessed by selected metrics, allowing for trade-offs in model selection considering computation time and accuracy. The selected model was then deployed to the edge, where they performed auxiliary classification tasks at the edge device.
Conclusions: This study discussed the significance of temporal bone U-HRCT imaging in the diagnosis of CSOM and MEC and proposed a cloud-edge collaborative model training framework for auxiliary classification from U-HRCT imaging data. This approach maximizes the utility of the data, fully leverages the diversity of image recognition algorithms, and ensures a high level of accuracy in classification.
Acetaminophen, a new tool to refine experimental infectious processes: the case of murine toxoplasmosis
Authors: Moiré Nathalie , Cauty Axel , Rossignol Christelle , Beaugé Corinne , Mérat Laetitia , Lortscher Emilie , Debierre-Grockiego Françoise , Dimier-Poisson Isabelle , Riou Mickaël 
Published: January 2025

Abstract

Over the past few years, animal welfare has taken more place in society and especially in scientific research. It has become necessary to refine the experimental procedures as much as possible in infectiology as in our reference model, toxoplasmosis, in agreement with the 3Rs rule and different ethical concerns. Thus, the establishment of a treatment using analgesics would relieve animals acutely infected with Toxoplasma gondii. However, the use of this analgesic should in no way alter the pathophysiology of the disease and the immune response of the host, so as not to interfere with the initial scientific study. Currently, little is known about the use of acetaminophen in an infectious model. In the present work, we studied the impact of acetaminophen at a reference dose of 30 mg/kg/day in a murine model of acute toxoplasmosis. To do this, zoonotic, telemetric, behavioral, histological and immune parameters were analyzed to better characterize the consequences of a treatment with acetaminophen either via gavage or via self-medication in Gel Water. Acetaminophen administered by gavage did not induce cellular or tissue toxicity and did not alter the physiological development of mice either. Moreover, the very nature of Gel Water, independently of APAP, has had an impact on the immune response. The acetaminophen improved the general well-being and slowed down the appearance of clinical signs without modifying the physiopathology or the immune responses induced by T. gondii. These first results in mice validated our initial hypothesis that acetaminophen appears to be a pharmacological tool to refine and improve animal welfare during the acute phase of toxoplasmosis. Therefore, our project has highlighted the combination of specific markers to contribute to animal welfare in mice. In the long term, the use of acetaminophen could be extended to other infectious models with other target animal species.
Earthquake Rupture Velocity and Stress-Drop Interaction in the Campi Flegrei Volcanic Caldera
Authors: Zollo Aldo , Nazeri Sahar , Muzellec Titouan , Toro Giulio Di 
Published: January 2025

Abstract

During earthquake ruptures, dynamic and static stress releases play a key role in controlling how much energy is radiated as seismic waves, how large is the fault slip, and how quickly the rupture spreads out of the nucleation zone. Here we exploit a time-domain technique using P- and S-waves log-displacement records to estimate the seismic moment, rupture velocity, and radius of the ruptures of 32 Md 3+ earthquakes detected during the 2020-2024 seismic crisis at Campi Flegrei caldera, Italy. Seismic ruptures propagated at sub-shear velocities (0.4-0.9 of shear wave speed) along 100-1000m in radius fault surfaces. Stress-drop estimates show a statistically significant inverse relation with the rupture velocity. The low seismic radiation efficiency confirms that the radiated energy is only a small fraction of the total available strain energy at the source which is mostly dissipated by friction and fracture-related processes. We argue that in volcanic calderas, the energy dissipation related to off-fault rock damage processes is the main cause for low radiation efficiency and inverse relation between the rupture velocity and stress drop. In this geologic environment, ruptures with higher stress drop favor extensive off-fault damage, which can prevent rupture propagation for long distances, limiting the maximum attainable earthquake magnitude.
The Comparative Effectiveness of Single versus Double Perclose ProGlide Devices in Achieving Transfemoral AortIc Valve Replacement Access Site Closure: A Prospective, Multicenter, Randomized Controlled Trial (Single-Closure)
Authors: Jiang Jubo , Wang Lihan , Hu Po , Ren Kaida , Lin Xinping , Zhu QiFeng , Fan Jiaqi , He Yuxin , Guo Yuchao , Liu Qiong , Liang Jie , Li Huajun , Yan Huixiang , Liu Xianbao , Wang Jian’an 
Published: January 2025

Abstract

Background
The Double Perclose ProGlide™ (Abbott Vascular Devices) is widely adopted device for closing the main arterial access in transfemoral transcatheter aortic valve replacement (TF-TAVR),. Prior studies have compared the single device versus double device approach, but yielding controversial results, highlighting a gap in clinical randomized controlled trials.
Trial design
This is an investigator-initiated, open-label, multicenter, randomized controlled trial designed to compare the clinical outcomes of single versus double Perclose closure devices. Eligible participants will include patients over 65 years ,with severe aortic stenosis and are indicated for TF-TAVR. These patients will be randomly assigned in a 1:1 ratio to either the single Perclose closure group or the double Perclose closure group. The primary end point of the trial is the rate of access site or access-related major and minor vascular complications,as defined by the VARC-3 criteria.
Conclusion
This trial aims to compare the clinical outcomes of single versus double Perclose closure. We aim to provide valuable insights into the optimal strategy for large-bore vascular closure in TAVR patients.
Is Endocan a Reliable Biomarker of Bone Tumours
Authors: ŞENOCAK EYÜP , ÖZTÜRK NURİNNİSA , AYGÜN ÜMİT , TOY SERDAR , ÇİÇEK ALİ CAN , AKSAY MEHMET FATİH , HALAÇ ORKUN 
Published: January 2025

Abstract

Endocan, which has an important role in inflammation and angiogenesis, is known to be an effective mediator in evaluating tumour progression and prognosis in many malignant tumour groups. Here, we investigated whether endocan is a biomarker that can be used to distinguish malignant from benign bone tumours. In all, 30 patients with pathologically malignant bone tumours, 30 patients with benign bone tumours, and 30 control patients without a tumour history were included in the study. The age and sex distributions of the three groups were statistically similar. Before biopsy, blood samples were taken from these patients without any medical or surgical intervention. The samples were centrifuged and stored under appropriate conditions. Inflammatory mediators other than endocan were also studied. There was a significant difference in endocan levels in the malignant bone tumour group compared to the benign bone tumour group. Similarly, a significant difference was detected in the group without bone tumours and the groups with benign or malignant bone tumours. A statistically significant correlation was observed between levels of serum endocan and the malignancy potential of bone tumours. The results indicate that endocan can be used as a biomarker to determine whether a bone tumour is benign or malign. Also, according to endocan levels, the severity of a bone tumour can be determined.
Collision Avoidance for Autonomous Ships Using Laser Rangefinder Technology
Authors: Nurdiansari Henna , Septianto Aditya , Setiawan Ariyono 
Published: January 2025

Abstract

This research aims to evaluate the performance of the Collision Avoidance System (CAS) Using a laser rangefinder sensor for Maritime Autonomous Surface Ships (MASS)[1], The system is designed to prevent collisions by providing early warnings and instructions based on the proximity of other objects. The study focuses on testing the CAS’s ability to detect obstacles and trigger Traffic Advisory (TA) and Resolution Advisory (RA) responses[2],[3]. Derived from the Airborne Collision Avoidance System (ACAS) used in aircraft, the maritime CAS system issues warnings and avoidance instructions when potential collisions are detected. It uses a laser rangefinder sensor to measure the distance to obstacles, triggering the TA or RA modes accordingly[4]. The system was tested through experiments assessing the sensor's detection range, obstacle sensitivity, battery life, and performance under varying light conditions. During the tests, the CAS responded appropriately by activating the TA with a buzzer and LED when obstacles were detected within 4000 mm, and engaged the RA by slowing the motor and adjusting the rudder when obstacles were within 2000 mm[5]. The system exhibited high sensitivity and reliable performance in different environments. This research contributes to the development of autonomous maritime technologies and highlights the potential of laser rangefinder sensors to enhance vessel safety and prevent accidents in busy marine settings