bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENUNDAAN PELAKSANAAN PERJANJIAN ANTARA PENGGUNA JASA DENGAN WEDDING ORGANIZER PADA MASA PANDEMI COVID-19 DI KOTA BENGKULU
Authors: Mexiarli Afrial , Dwi Arso Dimas , Muljono Slamet , Edytiawarman Edytiawarman 
Published: August 2023

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan Pelaksanaan kerjasama pengguna jasa dengan wedding organizer pada masa covid-19 di Kota Bengkulu Adapun jenis penelitian ini adalah penelitian hukum empiris, dengan metode penelitian kualitatif. Hasil penelitian bahwa: (1). Pelaksanaan kerjasama pengguna jasa dengan Wedding organizer pada masa covid-19 di Kota Bengkulu telah memenuhi unsur force majeure dan pandemi Covid-19 dapat dikualifikasikan sebagai force majeure, karena pada saat pandemi melanda, Pemerintah Indonesia telah menyatakan pandemi Covid-19 sebagai bencana nasional non-alam dengan dikeluarkannya KEPPRES Nomor 12 Tahun 2020 tentang Penetapan Bencana Non-alam Penyebaran coronavirus Disease 2019. Perizinan pernikahan di Kota Bengkulu harus mematuhi protokol kesehatan dan harus ada rekomendasi dari satgas covid-19 serta memenuhi syarat-syarat yang sudah ditentukan, apabila syarat tersebut dilanggar maka tim Satgas covid-19 Kota Bengkulu tidak akan mengeluarkan izin bahkan jika tetap berlangsung akan dibubarkan. Serta jika izin telah dikeluarkan maka harus ditunda dikarenakan munculnya penyebaran covid-19. Maka dari pada itu secara langsung membuat Focus Wedding Organizer tidak lagi dianggap wanprestasi, tetapi hanya diklasifikasikan sebagai force majeure. Di mana dengan terjadinya penundaan pelaksaan perjanjian tersebut membuat Focus Wedding Organizer dan pengguna jasa saling menyelesaikan. (2) Penyelesaian sengketa pada perjanjian pengguna jasa dengan Wedding Organizer dengan AA dan NE akibat keadaan covid-19. Dilakukan dengan musyawarah dan mufakat dimana pihak yang dirugikan akhirnya meminta biaya ganti rugi yang mana dalam kasus ini jumlah yang harus dibayar disetiap bulannya adalah sebesar Rp.1.645.000 (sejuta enam ratus empat puluh lima ribu rupiah) yang dibagi menjadi 5 bulan. Pembayaran angsuran akan di lakukan di setiap tanggal 20 dimulai dari bulan November dan 2020 berakhir pada bulan April 2021.
Kata Kunci : Perjanjian; Penyelesaian Sengketa; Wanprestasi.
IMPLEMENTASI PERATURAN MENTERI KEUANGAN NOMOR 190/PMK.07/2021 TENTANG PENGELOLAAN DANA DESA DI KECAMATAN BANG HAJI KABUPATEN BENGKULU TENGAH
Authors: Nopita Reza , Wulandari Wulandari , Suryaningsih Patricia Ekowati 
Published: August 2023

Bantuan Langsung Tunai Dana Desa adalah bantuan berupa uang yang diberikan kepada keluarga miskin di desa yang bersumber dari dana desa untuk mengurangi dampak pendemi COVID-19. Dalam proses pembagian BLT Dana Desa terdapat 6 kriteria yang diatur dalam Pasal 33 ayat (1) Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa. Penelitian ini bertujuan untuk mengetahui bagaimana implementasi dan faktor penghambat implemetasi Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa di Kecamatan Bang Haji Kabupaten Bengkulu Tengah. Penelitian ini merupakan penelitian hukum empiris. Hasil penelitian ini menunjukkan bahwa implementasi Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa di Kecamatan Bang Haji Kabupaten Bengkulu Tengah belum sesuai dengan Pasal 33 ayat (1), dimana seharusnya ada beberapa kriteria penerima Bantuan Langsung Tunai (BLT) Dana Desa, namun pada Desa Padang Burnai seluruh warga mendapatkan BLT tanpa memperhatikan kriteria yang telah ditentukan oleh pemerintah pusat, kecuali warga yang telah mendapatkan bantuan lainnya dari pemerintah. Sedangkan pada Desa Taba Tengah BLT Dana Desa diberikan kepada warga yang memenuhi kriteria yang telah ditentukan oleh pemerintah pusat. Adapun yang menjadi faktor penghambat dalam pengimplementasian Peraturan Menteri Keuangan Nomor 190/PMK.07/2021 tentang Pengelolaan Dana Desa di Kecamatan Bang Haji diantaranya faktor penghambat dari sisi Pemerintah dan dari sisi Masyarakat.

Kata Kunci : PMK No. 190, implementasi, dana desa, bantuan langsung tunai.
TRANSLATION SHIFTS AND EQUIVALENCE STRATEGY PRODUCED BY INSTAGRAM MACHINE TRANSLATION
Authors: Antika Ria 
Published: August 2023

The fast advancement of technology forces people to use it to simplify their lives. In the translation field, besides human translator, there is also machine translator used to help people in transferring the meaning of a text from source language (SL) to target language (TL). Along with the development of technology and social media, Instagram as one of the most famous social media platforms launched Instagram Machine Translation in 2016 that can help people to translate the captions and comments posted by the users. This study was conducted to identify the types of translation shift and the types of translation equivalence performed by Instagram machine translation in translating the captions on @instagram account from English to Indonesian. By using descriptive qualitative method to reach the goals of the study, the appropriate data were obtained. The data were analyzed based on the translation shifts theory from Catford (1965) and translation equivalence by Nida (1964). The findings showed that all types of Catford’s translation shifts were found in the translation process and the most common type was structure shift. It was also found that Instagram machine translation was successful in transferring the message from SL to TL equivalently.
Keywords: Translation shift, Translation equivalence, Instagram Machine Translation
Tumor-targeted bioactive nanoprobes visualizing of hydrogen peroxide for forecasting chemotherapy-exacerbated malignant prognosis
Authors: Zhang Fan , Jia Yong , Chen Fangman , Zhao Yawei , Li Li , Chang Zhimin 
Published: August 2023

Introduction: Fluorescent visualization of hydrogen peroxide in the tumor microenvironment (TME) is conducive to predicting malignant prognosis after chemotherapy. Two photon microscopy has been employed for in vivo hydrogen peroxide detection owing to its advantages of deep penetration and low phototoxicity.Methods: In this study, a two-photon fluorescent probe (TPFP) was protected by mesoporous silica nanoparticles (MSNs) and masked by cloaking the cancer cell membranes (CM), forming a tumor-targeted bioactive nanoprobe, termed MSN@TPFP@CM.Results: This multifunctional nanoprobe allowed for the effective and selective detection of excessive hydrogen peroxide production in chemotherapeutic Etoposide (VP-16)-challenged tumor cells using two-photon microscopy. After specific accumulation in tumors, VP-16-MSN@TPFP@CM monitored tumor-specific hydrogen peroxide levels and revealed a positive correlation between oxidative stress in the TME and chemotherapy-exacerbated malignant prognosis.Discussion: Given the recent translation of fluorescent imaging into early clinical trials and the high biocompatibility of bioactive nanoprobes, our approach may pave the way for specific imaging of oxidative stress in solid tumors after treatment and provide a promising technology for malignant prognosis predictions.
High specificity of metagenomic next-generation sequencing using protected bronchial brushing sample in diagnosing pneumonia in children
Authors: Zhang Chunyan , Li Zheng , Wang Mengyuan , Zhou Jiemin , Yu Wenwen , Liu Huifang , Hu Bingxue , Wang Shifu 
Published: August 2023

BackgroundLower respiratory tract infections are the leading cause of morbidity and mortality in children worldwide. Timely and accurate pathogen detection is crucial for proper clinical diagnosis and therapeutic strategies. The low detection efficiency of conventional methods and low specificity using respiratory samples seriously hindered the accurate detection of pathogens.MethodsIn this study, we retrospectively enrolled 1,032 children to evaluate the performance of metagenomics next-generation sequencing (mNGS) using bronchoalveolar lavage fluid (BALF) sample and protected bronchial brushing (BB) sample in diagnosing pneumonia in children. In addition, conventional tests (CTs) were also performed.ResultsThe specificity of BB mNGS [67.3% (95% CI 58.6%–75.9%)] was significantly higher than that of BALF mNGS [38.5% (95% CI 12.0%–64.9%)]. The total coincidence rate of BB mNGS [77.6% (95% CI 74.8%–80.5%)] was slightly higher than that of BALF mNGS [76.5% (95% CI 68.8%–84.1%)] and CTs [38.5% (95% CI 35.2%–41.9%)]. During the epidemics of Mycoplasma pneumoniae, the detection rate of M. pneumoniae in the &gt;6-year group (81.8%) was higher than that in the 3–6-year (78.9%) and &lt;3-year groups (21.5%). The highest detection rates of bacteria, fungi, and viruses were found in the &lt;3-year, &gt;6-year, and 3–6-year groups, respectively. mNGS detection should be performed at the duration of 5–7 days after the start of continuous anti-microbial therapy or at the duration of 6–9 days from onset to mNGS test.ConclusionsThis is the first report to evaluate the performance of BB mNGS in diagnosing pulmonary infections in children on a large scale. Based on our findings, extensive application of BB mNGS could be expected.
Development and validation of a novel nomogram for predicting recurrent atrial fibrillation after cryoballoon ablation
Authors: Wei Yue , Lin Changjian , Xie Yun , Bao Yangyang , Luo Qingzhi , Zhang Ning , Wu Liqun 
Published: August 2023

BackgroundFew studies have explored the use of machine learning models to predict the recurrence of atrial fibrillation (AF) in patients who have undergone cryoballoon ablation (CBA). We aimed to explore the risk factors for the recurrence of AF after CBA in order to construct a nomogram that could predict this risk.MethodsData of 498 patients who had undergone CBA at Ruijin Hospital, Shanghai Jiaotong University School of Medicine, were retrospectively collected. Factors such as clinical characteristics and biophysical parameters during the CBA procedure were collected for the selection of variables. Scores for all the biophysical factors—such as time to pulmonary vein isolation (TTI) and balloon temperature—were calculated to enable construction of the model, which was then calibrated and compared with the risk scores.ResultsA 36-month follow-up showed that 177 (35.5%) of the 489 patients experienced AF recurrence. The left atrial volume, TTI, nadir cryoballoon temperature, and number of unsuccessful freezes were related to the recurrence of AF (P &lt; .05). The area under the curve (AUC) of the nomogram's time-dependent receiver operating characteristic curve was 77.6%, 71.6%, and 71.0%, respectively, for the 1-, 2-, and 3-year prediction of recurrence in the training cohort and 77.4%, 74.7%, and 68.7%, respectively, for the same characteristics in the validation cohort. Calibration and data on the nomogram's clinical effectiveness showed it to be accurate for the prediction of recurrence in both the training and validation cohorts as compared with established risk scores.ConclusionBiophysical parameters such as TTI and cryoballoon temperature have a great impact on AF recurrence. The predictive accuracy for recurrence of our nomogram was superior to that of conventional risk scores.
Inclusion of interleukin-6 improved the performance of postoperative acute lung injury prediction for patients undergoing surgery for thoracic aortic disease
Authors: Li Huili , Feng Weiqi , Wang Qiuji , Li Chenxi , Zhu Jiade , Sun Tucheng , Wu Jinlin 
Published: August 2023

BackgroundWe studied acute lung injury (ALI) in thoracic aortic disease (TAD) patients and investigated the predictive effect of interleukin-6 (IL-6) in acute lung injury after thoracic aortic disease.MethodsData on 188 TAD patients, who underwent surgery between January 2016 to December 2021 at our hospital, were enrolled in. We analyzed acute lung injury using two patient groups. Patients with No-ALI were 65 and those with ALI were 123. Univariate logistic, LASSO binary logistic regression model and multivariable logistic regression analysis were performed for acute lung injury.ResultsPreoperative IL-6 level was lower (15.80[3.10,43.30] vs. 47.70[21.40,91.60] pg/ml, p &lt; 0.001) in No-ALI group than in ALI group. The cut-off points, determined by the ROC curve, were preoperative IL-6 &gt; 18 pg/ml (area under the curve: AUC = 0.727). Univariate logistic regression analysis showed 19 features for TAD appeared to be early postoperative risk factors of acute lung injury. Using LASSO binary logistic regression, 19 features were reduced to 9 potential predictors (i.e., Scrpost + PLTpost + CPB &gt; 182 min + D-dimerpost + D-dimerpre + Hypertension + Age &gt; 58 years + IL6 &gt; 18 pg/ml + IL6). Multivariable logistic regression analysis showed that Postoperative creatinine, CPB &gt; 182 min and IL-6 &gt; 18 pg/ml were early postoperative risk factors for ALI after TAD, and the odds ratios (ORs) of postoperative creatinine, CPB &gt; 182 min and IL-6 &gt; 18 pg/ml were 1.006 (1.002–1.01), 4.717 (1.306–19.294) and 2.96 (1.184–7.497), respectively. When postoperative creatinine, CPB &gt; 182 min and IL-6 &gt; 18 pg/ml (AUC = 0.819), the 95% confidence interval [CI] was 0.741 to 0.898. Correction curves were nearly diagonal, suggesting that the nomogram fit well. The DCA curve was then drawn to demonstrate clinical applicability. The DCA curve showed that the threshold probability of a patient is in the range of 30% to 90%.ConclusionsThe inclusion of interleukin-6 demonstrated good performance in predicting ALI after TAD surgery.
Apelin prevents diabetes-induced poor collateral vessel formation and blood flow reperfusion in ischemic limb
Authors: Robillard Stéphanie , Trân Kien , Lachance Marie-Sophie , Brazeau Tristan , Boisvert Elizabeth , Lizotte Farah , Auger-Messier Mannix , Boudreault Pierre-Luc , Marsault Éric , Geraldes Pedro 
Published: August 2023

IntroductionPeripheral arterial disease (PAD) is a major risk factor for lower-extremity amputation in diabetic patients. Unfortunately, previous clinical studies investigating therapeutic angiogenesis using the vascular endothelial growth factor (VEGF) have shown disappointing results in diabetic patients, which evokes the necessity for novel therapeutic agents. The apelinergic system (APJ receptor/apelin) is highly upregulated under hypoxic condition and acts as an activator of angiogenesis. Apelin treatment improves revascularization in nondiabetic models of ischemia, however, its role on angiogenesis in diabetic conditions remains poorly investigated. This study explored the impact of Pyr-apelin-13 in endothelial cell function and diabetic mouse model of hindlimb ischemia.MethodsNondiabetic and diabetic mice underwent femoral artery ligation to induce limb ischemia. Diabetic mice were implanted subcutaneously with osmotic pumps delivering Pyr-apelin-13 for 28 days. Blood flow reperfusion was measured for 4 weeks post-surgery and exercise willingness was assessed with voluntary wheels. In vitro, bovine aortic endothelial cells (BAECs) were exposed to normal (NG) or high glucose (HG) levels and hypoxia. Cell migration, proliferation and tube formation assays were performed following either VEGF or Pyr-apelin-13 stimulation.Results and DiscussionFollowing limb ischemia, blood flow reperfusion, functional recovery of the limb and vascular density were improved in diabetic mice receiving Pyr-apelin-13 compared to untreated diabetic mice. In cultured BAECs, exposure to HG concentrations and hypoxia reduced VEGF proangiogenic actions, whereas apelin proangiogenic effects remained unaltered. Pyr-apelin-13 induced its proangiogenic actions through Akt/AMPK/eNOS and RhoA/ROCK signaling pathways under both NG or HG concentrations and hypoxia exposure. Our results identified the apelinergic system as a potential therapeutic target for angiogenic therapy in diabetic patients with PAD.
Patent iliolumbar artery increase no risk of type II endoleaks after endovascular abdominal aortic aneurysm: a case-control study
Authors: Chen Guo Xin , Liu Dan , Weng Chengxin , Chen Chuwen , Wan Jianghong , Zhao Jichun , Yuan Ding , Huang Bin , Wang Tiehao 
Published: August 2023

ObjectiveThe aims of the present study were to explore the risk factors for type 2 endoleaks (T2ELs) after endovascular aneurysm repair (EVAR) and the association between T2ELs and the iliolumbar artery.Materials and methodsA single-center, retrospective case–control study in West China Hospital was conducted among patients with infrarenal abdominal aortic aneurysm (AAA) who underwent EVAR between June 2010 and June 2019. The associations of patient characteristics, anatomical factors, internal iliac artery embolization, and ILA with the primary outcome were analyzed. The secondary objective was to analyze survival and reintervention between the T2EL group and the non-T2EL group. Kaplan–Meier survival, propensity matching analysis and multivariate logistic regression analysis were used.ResultsA total of 603 patients were included. The median follow-up was 51 months (range 5.0–106.0). There was a significant difference in the diameter of the lumbar artery (LA), middle sacral artery (MSA) and inferior mesentery artery (IMA), proportion of thrombus and LA numbers. The univariate analysis showed that T2ELs were more likely to develop more thrombus in aneurysm cavity (OR = 0.294, p = 0.012), larger MSA (OR = 1.284, p = 0.04), LA (OR = 1.520, p = 0.015), IMA (OR = 1.056, p &lt; 0.001) and more LAs (OR = 1.390, p = 0.019). The multivariate analysis showed that the number of LAs (HR: 1.349, 95% CI: 1.140–1.595, p &lt; .001) and the diameter of the IMA (HR: 1.328, 95% CI: 1.078–1.636, p = 0.008) were significantly associated with T2ELs. There were no new findings from the propensity score matching. The reintervention-free survival rates were significantly different between the two groups (p = 0.048). Overall survival and AAA-related death rates were not different between the two group. This was consistent with the PSM analysis.ConclusionThe iliolumbar artery and the different internal iliac artery interventions may not increase the incidence of T2ELs. But the numbers of LAs and IMA diameter were independent risk factors for T2Els. T2ELs was associated with the reintervention but did not affect long-term survival or increase aneurysm-related mortality after EVAR.
Associated congenital heart disease with Hirschsprung's disease: a retrospective cohort study on 2,174 children
Authors: Wu Yujian , Zhu Yun , Zhang Xu , Feng Jinqing , Xia Huimin , Zhang Yan , Li Jia 
Published: August 2023

ObjectiveTo examine the incidence and phenotypes of congenital heart disease (CHD) in a large cohort of patients with Hirschsprung's disease (HSCR).Study designRetrospective data review of children with HSCR between 2003 and 2020 was conducted at the Provincial Key Laboratory for Structural Birth Defects in Guangzhou, Guangdong, China. HSCR was confirmed by pathological diagnosis. CHD was defined as a gross structural abnormality of the heart or intrathoracic great vessels that is of functional significance.ResultsA total of 2,174 HSCR patients (84.7% males) were studied and 306 of them underwent echocardiography. Overall, 27 children (1.2%) had associated CHD. Among them, CHDs mostly presented as atrial and ventricular septal defects (n = 5 and 12 respectively) and patent ductus arteriosus (n = 4). Three patients (1.4‰) presented as a severe CHD including complete atrioventricular canal, congenitally corrected transposition of the great arteries and double-outlet of right ventricle. Among 14 patients carrying a chromosomal abnormality, CHD was detected in 4 infants (28.6%), all being mild forms of septal defects.ConclusionsSome new and severe types of CHD were found in patients with HSCR. Patients with syndromic features had higher incidence of CHD.
Prognostic significance of delirium in patients with heart failure: a systematic review and meta-analysis
Authors: Niu Ziru , Zhou Jiamin , Li Yongjun 
Published: August 2023

BackgroundDelirium is a common symptom of heart failure (HF) and is associated with increased mortality, prolonged hospital stays, and heightened medical costs. The impact of delirium on the prognosis of HF patients is currently controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic significance of delirium in HF.MethodsRelevant articles were systematically searched in PubMed, Cochrane Library, Web of Science, and Embase based on the PRISMA guidelines. Studies that reported mortality and hospitalization-related outcomes in HF patients with or without delirium using raw or adjusted hazard ratio (HR) and odds ratio (OD) were included. Meta-analysis was then performed to evaluate the effect of delirium in HF patients. Outcomes of interest were all-cause mortality and events of the hospitalization.ResultsOf the 1,501 studies identified, 7 eligible studies involving 12,830,390 HF patients (6,322,846 males and 6,507,544 females) were included in the meta-analysis. There were 91,640 patients with delirium (0.71%) and 12,738,750 patients without delirium (99.28%). HF patients with delirium had higher OR for in-hospital mortality (1.95, 95% CI = 1.30–2.91, P = 0.135), higher pooled HR for 90-day mortality (2.64, 95% CI = 1.06–1.56, P = 0.215), higher pooled HR for 1-year mortality (2.08, 95% CI = 1.34–3.22, P = 0.004), and higher pooled HR for 30-day readmission rate (4.15, 95% CI = 2.85–6.04, P = 0.831) than those without delirium.ConclusionCurrent evidence suggests that combined delirium increases the risk of HF-related mortality and hospitalization-related outcomes in patients with HF. However, more research is needed to assess the impact of delirium on the prognosis of HF patients.
Global trends in research of endoscopic thyroidectomy from 2013 to 2022: a scientometric and visualization analysis
Authors: Zheng Daitian , Yang Qiuping , Wu Jinyao , Zhou Zhongming , Cai Jiehui , Chen Lingzhi , Ji Zeqi , Tian Huiting , Li Zhiyang , Chen Yexi 
Published: August 2023

IntroductionRecently, endoscopic thyroidectomy has been developed and applied to thyroid surgery to achieve minimized neck scar formation and enhanced aesthetic outcomes. Our scientometric research in this paper offers a thorough overview of endoscopic thyroidectomy from 2013 to 2022.MethodsAll pertinent articles on endoscopic thyroidectomy were obtained from the Web of Science Core Collection Database. The data on the number of citations and publications, most prolific countries and institutions, significant authors and journals, top themes, and keywords were analyzed by Biblioshiny, CiteSpace, and VOSviewer.ResultsThere were 758 publications, all of that were found from 2013 to 2022. The output of the annual publication showed an upward trend. A series of cases report by Anuwong et al. published in 2016 received the most citations. The country with the most articles published articles was South Korea, and the two countries with the most collaboration were South Korea and the United States. The most productive journal was Surgical Endoscopy and Other Interventional Techniques. Dionigi G, Kim HY, and Anuwong A were the writers with the most articles published, the highest h- and g-indices, and the strongest link strength, respectively. The keywords “endoscopic thyroidectomy”, “surgical”, “thyroidectomy”, “robotic thyroidectomy”, “experience”, and others were most used.ConclusionThe innovative surgical technique, transoral endoscopic thyroidectomy vestibular approach (TOETVA), leaves no scars and produces optimal cosmetic results. However, the long-term oncologic results for thyroid cancer performed with this approach are still missing. This scientometric analysis can offer valuable insights into the present research standing and key focal points in this domain, enabling researchers to gain a precise understanding of the state-of-the-art research in this area.