bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can collaboration among health and social care workers play a role in addressing geriatric care challenges? A qualitative case study in Central Vietnam
Authors: Vo Man Thi Hue , Nakamura Keiko , Seino Kaoruko , Moncatar T J Robinson T , Han Tran Dai Tri , Siongco Kathryn Lizbeth L , Tashiro Yuri , Van Vo Thang 
Published: September 2023

AbstractBackgroundVietnam's healthcare system offers limited services and facilities for older adults. This study explored the perceptions of health and social care workers regarding geriatric care issues, their impact on older adults and the potential of collaboration for enhancing older adults’ health and well-being.MethodsThis qualitative case study employed 27 focus group discussions and two in-depth interviews with 174 participants in Thua Thien Hue Province, Vietnam. An inductive thematic analysis was conducted.ResultsAccording to the participants, the major challenges that hindered geriatric care consisted of caregiver and care recipient issues, which were identified to constrain care accessibility, resulting in decreased physical, mental and social health. Across different settings and professions, collaboration was considered a routine and natural aspect of daily work. It was perceived that establishing and strengthening collaboration could facilitate improvement in health and social welfare services through the prioritization of needs and enhancement of caregiver skills and training.ConclusionsCollaboration was viewed as ad hoc but indispensable for addressing the identified geriatric care issues that could improve the general health and well-being of older adults. The findings indicate a need for better collaboration in Vietnam, achieved through defined guidelines, training and improved interprofessional education and practice.
Are unknown co-medications, over-the-counter and off-label drug use still problems among people living with HIV? Results from a transversal survey in 23 centres in France
Authors: Tetart Macha , Passecountrin Priscila , Lesourd Anaïs , Sanderink Diane , Le Moal Gwenaël , Surgers Laure , Beraud Guillaume , Katlama Christine , Robineau Olivier , Parienti Jean-Jacques ,   the COMEDWEEK Study group, Tetart Macha , Passecountrin Priscila , Lesourd Anaïs , Sanderink Diane , Le Moal Gwenaël , Surgers Laure , Bonneton Marion , Etienne Manuel , Beraud Guillaume , Katlama Christine , Robineau Olivier , Parienti Jean-Jacques , Valin Nadia , Fontier Clotilde , Lucarelli Aude , Letertre-Gibert Paule , Hentzien Maxime , Fournier Anna , Legrain Agathe , Ménard Amélie , Salmon Dominique , Markowicz Samuel , Garnotel Marie , Janssen Cécile , Bataille Pierre , Castan Bernard , Zabbe Jean-Benoît , Jacomet Christine , Chirio David , Puges Mathilde 
Published: September 2023

Abstract

Introduction
Polypharmacy can lead to drug–drug interactions (DDIs), especially with ART. The burden of co-medications, including over-the-counter (OTC) drugs and self-medications, could be underestimated. We aimed to investigate the proportion of people living with HIV (PLHIV) with declared and undeclared co-medications, as well as their potential burden.

Methods
We conducted a national, multicentre, 1 week cross-sectional study between 10 December and 16 December 2019 in 23 French hospitals amongst consecutive adult PLHIV presenting for a routine outpatient visit. A standardized questionnaire filled in by the physicians assessed all medications and other active chemical substances taken by the PLHIV.

Results
Overall we enrolled 496 participants from 23 centres. Median age was 50.6 years; ART regimens included an integrase inhibitor in 61% (n = 302), an NNRTI in 34% (n = 169) and a PI in 14% (n = 70) of the cases. Co-medications involved 392 (79%) PLHIV, among which 85 (17%) received polypharmacy (≥5 medications). Previously unknown co-medications or other active substances were found for 32% (n = 159) of the participants. Corticosteroids (9%, n = 46) and proton pump inhibitors (10%, n = 50) were frequently administered. These co-medications did not differ according to age range. Illegal drug use was declared by 11% (n = 54) and OTC drugs by 23% (n = 113) of PLHIV. Potential DDIs were discovered for 11% (n = 53), leading to treatment modifications in 47% (25/53) of cases.

Conclusions
Potential DDIs that lead to therapeutic modifications remain significant whatever the age of PLHIV. More devoted time to identify co-medications and OTC treatment is needed in all PLHIV.
Nitrogen and lysine utilization efficiencies, protein turnover, and blood urea concentrations in crossbred grower pigs at marginal dietary lysine concentration
Authors: Berghaus Daniel , Haese Eva , Weishaar Ramona , Sarpong Naomi , Kurz Alina , Seifert Jana , Camarinha-Silva Amélia , Bennewitz Jörn , Chillon Thilo , Stefanski Volker , Rodehutscord Markus 
Published: September 2023

Abstract
Nitrogen utilization efficiency (NUE) and lysine utilization efficiency (LUE) are key indicators of sustainable pork production and vary depending on nutritional and non-nutritional factors. The objective was to study NUE and LUE together with concentrations of blood urea nitrogen (BUN) and other metabolites in growing pigs fed diets with marginal Lys concentrations at 11–13 wk (40.5 kg mean BW) and 14 to 16 wk (60.2 kg mean BW). The cereal grain–soybean meal-based diets contained 10.6 and 7.9 g Lys/kg DM in periods 1 and 2, respectively. Feed intake and BW were measured for 508 individually penned pigs, and blood samples were collected 5 h after morning feeding at weeks 13 and 16. A subgroup of 48 barrows was used in a nitrogen (N) metabolism trial at weeks 13 and 16. In this subgroup, the mean N retention of pigs (27.3 g N/d) and mean LUE (70%) were not different between the periods, but NUE was higher in period 1 (47%) than in period 2 (43%) (P &lt; 0.001). After administration of a single dose of 15N labeled glycine and measurement of 15N recovery in urine, the calculated whole-body protein turnover did not differ between the periods. The rate of protein synthesis was positively correlated with NUE (P &lt; 0.001), but protein degradation was not. Excretion of urea-N in urine accounted for 80% of the total urinary N and was positively correlated with BUN. The N retention of all 508 pigs was estimated using an equation that was derived from the N metabolism data. N retention was on average 31.4 g/d, equal in both periods, and higher in barrows than in gilts in period 2, but not in period 1 (P = 0.003). The calculated NUE was, on average, 47% and was lower in barrows than in gilts (P &lt; 0.001) and higher in period 1 than in period 2 (P &lt; 0.001). The calculated LUE was, on average, 71%, and was lower in barrows than in gilts in period 2, but not in period 1 (P &lt; 0.001). The BUN concentration was higher in barrows than in gilts (P &lt; 0.001) and higher in period 1 than in period 2 (P &lt; 0.001). BUN concentration was negatively correlated with NUE in Periods 1 (r = -0.50) and 2 (r = -0.15) (P &lt; 0.05). We concluded that the maximum LUE was in the range of 70–72% under the conditions of this study, and only small differences between the periods and sexes existed. Protein synthesis, rather than degradation, appears to affect NUE. BUN concentration may be useful for estimating NUE in a large group of animals fed a diet with a marginal Lys concentration.
Detection of thiocyanate in postmortem blood of a fatal potassium thiocyanate-poisoning patient using gas chromatography–mass spectrometry
Authors: Kang Minji , Moon Sungmin , Kim Byungjoo , Kim So-Hyun , Kim Junghyun , Park Heejin , Choi Hyeyoung , Kim Seongho , Park Meejung 
Published: September 2023

Abstract
Thiocyanate is an inorganic compound used in industrial applications. Here, we report a case of suicidal death due to acute thiocyanate overdose. A 44-year-old man who consumed an unknown amount of thiocyanate solution was transferred to the emergency room and died 2 h after admission. An autopsy was performed 2 days after death. General toxicological analysis of blood using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–tandem mass spectrometry found no drug or alcohol. Quantification using GC–MS post-derivatization with pentafluorobenzyl bromide revealed 2,290 and 1,920 mg/L of thiocyanate in the heart and femoral blood samples, respectively. Thus, the cause of death was attributed to thiocyanate overdose. This study provides useful information for the interpretation of thiocyanate-related fatalities.
Dominance Effects in the Wild
Authors: Fridman Ariel , Amir On , Hansen Karsten T 
Published: September 2023

Abstract
In real-world marketplaces, one may encounter an alternative that is inferior to another one in the assortment. While the presence of such seemingly irrelevant inferior alternatives should ostensibly have no influence on consumers’ decisions, an extensive literature using stylized lab experiments has found that, surprisingly, their presence matters. Specifically, the dominance effect suggests that the presence of an inferior alternative shifts consumer’s preferences toward the alternative made to be superior. However, null results in some recent lab studies and a lack of real-world evidence call into question whether, when, and how the effect exists. In this work, we find clear evidence that dominance matters in the wild. We also identify an important moderator for the dominance effect—preference uncertainty—and test it in both a real-world marketplace for digital freelance services and a lab experiment. Further, we find evidence for additional moderators that help explain how the effect works, including the count of dominated alternatives and the magnitude of dominance, consistent with a perceptual mechanism. This work is the first to use consequential field data to shed light on when and why the dominance effects occur, with implications for marketers, choice architects, user interface designers, and policymakers.
Decentralization and Corruption in Public Service Delivery: Local Institutional Arrangements That Can Help Reduce Governance Risks
Authors: Zarychta Alan , Benedum Michelle E , Sanchez Emily , Andersson Krister P 
Published: September 2023

Abstract
Decentralization reform has both advantages and risks. Bringing service delivery “closer to the people” can improve information flows and strengthen accountability, but it may also leave systems vulnerable to elite capture and corruption by municipal government officials. While past research has acknowledged the possibility of corruption under decentralization, relatively little work has connected those risks to features of these reforms or specific local institutional arrangements. To explore the conditions that can help mitigate the risks of corruption under decentralization, we study the case of health sector reform in Honduras where municipal governments, associations, and NGOs each serve as intermediary-managing organizations under a common decentralized health service delivery model. We argue that three types of institutional arrangements reflecting local accountability practices serve as checks on the authority granted through decentralization and can help guard against corruption: external supervision, civil society engagement, and public participation. Empirically, we draw on data from more than 600 street-level bureaucrats, valuable but under-utilized informants about municipal corruption, across a matched sample of 65 municipalities with contrasting forms of administration. We find that reported corruption is highest under decentralization led by municipal governments, as compared to association- or NGO-led varieties. Both external supervision and civil society engagement help attenuate the positive association between decentralization and corruption, but public participation does not. Overall, this research highlights the importance of considering reform features and local conditions when designing policies to help manage risks and support effective social sector decentralization.
Studying with a teacher: education beyond the logic of progress
Authors: Zamojski Piotr 
Published: September 2023

AbstractThe article presents a thought experiment aimed at indicating a possibility for thinking education beyond the logic of progress. In its first part, the argument reconstructs the entanglement of the modern idea of progress (as found in Francis Bacon and Comenius) and education, while tracking down the specific coupling of obedience and conquest at work. Through such an analysis a link between the ideas of progress and of emancipation is determined, which leads to the acknowledgement of the difficulty of the task of imagining education outside of the logic of progress. In the second part an attempt is made to match this task by suggesting that when studying with a teacher, the logic of progress is deactivated. A phenomenological analysis of the practices involved in studying with a teacher points to a specific way of living together that such a collective study involves. This way of living together is formed by continual exercises in the humble equality realized through shared attention to something worthy of study: this stems from attentiveness to what exists, and it develops an attitude of care and respect for being as such.
Exploring the extensin gene family: an updated genome-wide survey in plants and algae
Authors: Cheng Sou-Yu , Chu Ping-Kuan , Chen Yi-Jing , Wu Yun-Hsuan , Huang Ming-Der 
Published: September 2023

Abstract
Extensins (EXTs), a class of hydroxyproline-rich glycoprotein with multiple Ser-Pro3–5 motifs, are known to play roles in cell wall reinforcement and environmental responses. EXTs with repetitive Tyr-X-Tyr (YXY) motifs for crosslinking are referred as crosslinking EXTs. Our comprehensive study spanned 194 algal and plant species, categorizing EXTs into seven subfamilies: classical extensins (EXT I and II), arabinogalactan-protein extensins (AGP-EXTs), proline-rich extensin-like receptor kinases (PERKs), leucine-rich repeat extensins (LRX I and II), formin homology (FH) domain-containing extensins (FH-EXTs), proline-rich, arabinogalactan proteins, conserved cysteines (PAC) domain-containing extensins (PAC I and II), and eight-cysteine motif (8CM)-containing extensins (8CM-EXTs). In the examined dataset, EXTs were detected ubiquitously in plants but infrequently in algae, except for one Coccomyxa and four Chlamydomonadales species. No crosslinking EXTs were found in Poales or certain Zingiberales species. Notably, the previously uncharacterized EXT II, PAC II, and liverwort-specific 8CM-EXTs were found to be crosslinking EXTs. EXT II, featuring repetitive YY motifs instead of the conventional YXY motif, was exclusively identified in Solanaceae. Furthermore, tandem genes encoding distinctive 8CM-EXTs specifically expressed in the germinating spores of Marchantia polymorpha. This updated classification of EXT types allows us to propose a plausible evolutionary history of EXT genes during the course of plant evolution.
Tetracosanoic acids produced by 3-ketoacyl-CoA synthase 17 are required for synthesizing seed coat suberin in Arabidopsis
Authors: Kim Ryeo Jin , Han Sol , Kim Hyeon Jun , Hur Ji Hyun , Suh Mi Chung 
Published: September 2023

Abstract
Very long-chain fatty acids (VLCFAs) are precursors for the synthesis of membrane lipids, cuticular waxes, suberins, and storage oils in plants. 3-Ketoacyl CoA synthase (KCS) catalyzes the condensation of C2 units from malonyl-CoA to acyl-CoA, the first rate-limiting step in VLCFA synthesis. In this study, we revealed that Arabidopsis KCS17 catalyzes the elongation of C22–C24 VLCFAs required for synthesizing seed coat suberin. Histochemical analysis of Arabidopsis plants expressing GUS (β-glucuronidase) under the control of the KCS17 promoter revealed predominant GUS expression in seed coats, petals, stigma, and developing pollen. The expression of KCS17:eYFP (enhanced yellow fluorescent protein) driven by the KCS17 promoter was observed in the outer integument1 of Arabidopsis seed coats. The KCS17:eYFP signal was detected in the endoplasmic reticulum of tobacco epidermal cells. The levels of C22 VLCFAs and their derivatives, primary alcohols, α,ω-alkane diols, ω-hydroxy fatty acids, and α,ω-dicarboxylic acids increased by ~2-fold, but those of C24 VLCFAs, ω-hydroxy fatty acids, and α,ω-dicarboxylic acids were reduced by half in kcs17-1 and kcs17-2 seed coats relative to the wild type (WT). The seed coat of kcs17 displayed decreased autofluorescence under UV and increased permeability to tetrazolium salt compared with the WT. Seed germination and seedling establishment of kcs17 were more delayed by salt and osmotic stress treatments than the WT. KCS17 formed homo- and hetero-interactions with KCR1, PAS2, and ECR, but not with PAS1. Therefore, KCS17-mediated VLCFA synthesis is required for suberin layer formation in Arabidopsis seed coats.
Characterizing the true descendants of the first stars
Authors: Vanni Irene , Salvadori Stefania , Skúladóttir Ása , Rossi Martina , Koutsouridou Ioanna 
Published: September 2023

ABSTRACT
The metal-poor stars in the Galactic halo are thought to show the imprints of the first (Pop III) stars, and thus provide a glance at the first episodes of star formation. In this work, we aim at understanding whether all very metal-poor stars formed in environments polluted by Pop III supernovae (SNe) and at what level. With a general parametric model for early metal enrichment, we study the chemical abundances (from C to Zn) of an environment imprinted by a single Pop III SN. We investigate how these abundances depend on the initial mass and internal mixing of Pop III stars, as well as on their SN explosion energy. We then study how subsequent generations of normal (Pop II) SNe affect the Pop III chemical signatures. By comparing the observed chemical abundances with our model predictions, we show that stars with [C/Fe] &gt; +2.5 form in environments polluted purely by low-energy Pop III SNe (ESN &lt; 2 × 1051 erg). At lower [C/Fe], stars can be imprinted either by Pop III only, or also by normal Pop II SNe. The probability of being enriched by Pop II SNe increases as [C/Fe] decreases. When Pop II stars contribute more to the pollution, they wash out the diverse chemical peculiarities left by the different Pop III SNe, and the chemical dispersion between their descendants decreases. We conclude that C-normal stars ($\rm [C/Fe] \le +0.7$) have likely been enriched by Pop II SNe at a $\ge 50~{{\ \rm per\ cent}}$ level and we identify in the abundance scatter a key diagnostic to pinpoint the signature of Pop III SNe.
ALMA Lensing Cluster Survey: average dust, gas, and star-formation properties of cluster and field galaxies from stacking analysis
Authors: Guerrero Andrea , Nagar Neil , Kohno Kotaro , Fujimoto Seiji , Kokorev Vasily , Brammer Gabriel , Jolly Jean-Baptiste , Knudsen Kirsten , Sun Fengwu , Bauer Franz E , Caminha Gabriel B , Caputi Karina , Neumann Gerald , Orellana-González Gustavo , Cerulo Pierluigi , González-López Jorge , Laporte Nicolas , Koekemoer Anton M , Ao Yiping , Espada Daniel , Arancibia Alejandra M Muñoz 
Published: September 2023

ABSTRACT
We develop new tools for continuum and spectral stacking of Atacama Large Millimeter/submillimeter Array (ALMA) data, and apply these to the ALMA Lensing Cluster Survey. We derive average dust masses, gas masses, and star-formation rates (SFRs) from the stacked observed 260-GHz continuum of 3402 individually undetected star-forming galaxies, of which 1450 are cluster galaxies and 1952 field galaxies, over three redshift and stellar mass bins (over z = 0–1.6 and log$M_{*} \, [{\rm M}_{\odot }] = 8$–11.7), and derive the average molecular gas content by stacking the emission line spectra in a SFR-selected subsample. The average SFRs and specific SFRs of both cluster and field galaxies are lower than those expected for main-sequence (MS) star-forming galaxies, and only galaxies with stellar mass of log$M_{*} \, [{\rm M}_{\odot }] = 9.35$–10.6 show dust and gas fractions comparable with those in the MS. The ALMA-traced average ‘highly obscured’ SFRs are typically lower than the SFRs observed from optical to near-infrared spectral analysis. Cluster and field galaxies show similar trends in their contents of dust and gas, even when field galaxies were brighter in the stacked maps. From spectral stacking we find a potential CO (J = 4 → 3) line emission (signal-to-noise ratio being ∼4) when stacking cluster and field galaxies with the highest SFRs.
The influence of subhaloes on host halo properties
Authors: Mezini Lorena , Fielder Catherine E , Zentner Andrew R , Mao Yao-Yuan , Wang Kuan , Wu Hao-Yi 
Published: September 2023

ABSTRACT
Within the ΛCDM cosmology, dark matter haloes are composed of both a smooth component and a population of smaller gravitationally bound subhaloes. These components are often treated as a single halo when properties, such as density profiles, are extracted from simulations. Recent work has shown that density profiles change substantially when subhalo mass is excluded. In this paper, we expand on this result by analysing three specific host halo properties – concentration (cNFW), spin (λB), and shape (c/a) – when calculated only from the smooth component of the halo. This analysis is performed on both Milky Way-mass haloes and cluster-mass haloes in high-resolution zoom-in N-body simulations. We find that when subhaloes are excluded, the median value of (1) cNFW is enhanced by $\approx 30\pm 11$ and $\approx 77\pm 8.1~{{\ \rm per\ cent}}$ for Milky Way-mass ($10^{12.1}\, \text{M}_\odot$) and cluster-mass ($10^{14.8}\, \text{M}_\odot$) haloes, respectively, (2) λB is reduced for Milky Way-mass by $\approx 11\pm 4.9~{{\ \rm per\ cent}}$ and cluster-mass haloes by $\approx 27\pm 3.5~{{\ \rm per\ cent}}$. Additionally, with the removal of subhaloes, cluster-mass haloes tend to become more spherical as the ratio of minor-to-major axis, c/a, increases by $\approx 11\pm 3.6~{{\ \rm per\ cent}}$, whereas Milky Way-mass haloes remain approximately the same shape with c/a changed by $\approx 1.0\pm 5.8~{{\ \rm per\ cent}}$. Fractional changes of each of these properties depend primarily on the amount of mass in subhaloes and, to a lesser extent, mass accretion history. Our findings demonstrate that the properties of the smooth components of dark matter haloes are biased relative to the total halo mass.
Numerical modelling of the lobes of radio galaxies – Paper V: universal pressure profile cluster atmospheres
Authors: Stimpson M , Hardcastle M J , Krause M G H 
Published: September 2023

ABSTRACT
We present relativistic magnetohydrodynamic modelling of jets running into hydrostatic, spherically symmetric cluster atmospheres. For the first time in a numerical simulation, we present model cluster atmospheres based upon the universal pressure profile (UPP), incorporating a temperature profile for a ‘typical’ self-similar atmosphere described by only one parameter – M500. We explore a comprehensive range of realistic atmospheres and jet powers and derive dynamic, energetic, and polarimetric data which provide insight into what we should expect of future high-resolution studies of AGN outflows. From the simulated synchrotron emission maps which include Doppler beaming we find sidedness distributions that agree well with observations. We replicated a number of findings from our previous work, such as higher power jets inflating larger aspect-ratio lobes, and the cluster environment impacting the distribution of energy between the lobe and shocked regions. Comparing UPP and β-profiles we find that the cluster model chosen results in a different morphology for the resultant lobes with the UPP more able to clear lobe material from the core; and that these different atmospheres influence the ratio between the various forms of energy in the fully developed lobes. This work also highlights the key role played by Kelvin–Helmholtz instabilities in the formation of realistic lobe aspect ratios. Our simulations point to the need for additional lobe-widening mechanisms at high jet powers, for example jet precession. Given that the UPP is our most representative general cluster atmosphere, these numerical simulations represent the most realistic models yet for spherically symmetric atmospheres.