bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating pelvic rotator strength: Investigating asymmetry and its correlation with pelvic rotation angle during active straight leg raise
Authors: Jeon Joo-Young , Kwon Oh-Yun , Yi Chung-Hwi , Ha Sung-Min , Kim Jun-Hee , Han Seung-Yoon 
Published: January 2025

Background Although lumbopelvic rotation control muscle is important to maintain pelvic neutral alignment during active straight leg raise (ASLR), pelvic rotator strength has not been evaluated. Thus, a novel method is needed to measure pelvic rotator strength and to determine whether pelvic rotator muscle asymmetry is related to side difference in transverse plane pelvic rotation angle (TrPRA) during ASLR. Objective To find average pelvic rotator strength, verify the reliability of pelvic rotator strength measurement method, and identify the correlation between pelvic rotator strength asymmetry and side difference in TrPRA during ASLR. Methods Forty healthy participants were enrolled. Pelvic rotator strength was measured using a hand-held dynamometer. TrPRA was measured using a smart KEMA motion sensor. Reliability was analyzed using intraclass correlation coefficient (ICC). The correlation between pelvic rotator strength asymmetry and side difference in TrPRA during ASLR was analyzed using Pearson's correlation coefficient. Results The average pelvic rotator strength was 120.3 N (72.9–202.2) for males and 94.4 N (58–125.8) for females. The reliability of pelvic rotator strength measurement demonstrated good to excellent intra- (ICC = 0.87–0.97) and inter-rater (ICC = 0.93–0.98) values. A significant moderate relationship existed between pelvic rotator strength asymmetry and side difference in TrPRA during ASLR (r = 0.39, p < 0.05). Conclusion The pelvic rotator muscle strength measurement method can be clinically used with good to excellent intra- and inter-rater reliability. Pelvic rotator strength asymmetry should be considered to evaluate and manage the pelvic rotation control during ASLR.
Benefit Finding in Craniofacial Conditions: A Qualitative Analysis of Patient and Parent Perspectives
Authors: Choi Alyssa K. , Korhummel Megan , Belza Caitlyn C. , Herrera Eguizabal Josseline , Olfus Sydney , Rapoport Chelsea S. , Blum Jessica , Tapia Viridiana J. , Drizin Julia H. , Gosman Amanda , Malcarne Vanessa L. 
Published: January 2025

Objective Craniofacial conditions (CFCs) can be associated with adverse effects on quality of life (QoL). However, few studies have examined perceived benefits related to CFCs. This study described perceived benefits in an international sample of children and adolescents with CFCs and their parents. Design Semistructured qualitative interviews were completed in English or Spanish as part of a larger study. Deductive content analysis described and quantified perceived benefits associated with CFCs. Setting Interviews were during standard visits at Rady Children's Hospital-San Diego in the USA and the Hospital Infantil de las Californias in Tijuana, Baja California, Mexico. Participants Patients were ages 7 to 20 years ( n = 32) with CFCs (cleft lip and/or palate, craniosynostosis, microtia, hemifacial microsomia, dermatologic conditions/neurovascular malformations, and trauma-acquired CFC), and parents ( n = 71) had children ages 5 months to 23 years with CFCs. Of the total sample, there were 14 patient-parent dyads. Results A total of 230 benefits were identified. Of the patients (47%) and parents (73%) who identified at least 1 benefit, themes included personal growth (40%), understanding or helping others facing challenges (25%), social relationships (23%), spiritual or religious beliefs (4%), philanthropy (4%), material or external gains (3%), and personal health (1%). Conclusions Patients with CFCs and their parents report multiple positive effects of CFCs on their QoL. These findings indicate that benefit finding is a common experience in this population and may be leveraged by clinicians to help promote positive adjustment to living with a CFC.
The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum
Authors: Mijanović Lucija , Putar Darija , Mimica Lucija , Klajn Sabina , Filić Vedrana , Weber Igor 
Published: January 2025

AbstractProper adhesion of cells to their environment is essential for the normal functioning of single cells and multicellular organisms. To attach to the extracellular matrix (ECM), mammalian cells form integrin adhesion complexes consisting of many proteins that together link the ECM and the actin cytoskeleton. Similar to mammalian cells, the amoeboid cells of the protist Dictyostelium discoideum also use multiprotein adhesion complexes to control their attachment to the underlying surface. However, the exact composition of the multiprotein complexes and the signaling pathways involved in the regulation of adhesion in D. discoideum have not yet been elucidated. Here, we show that the IQGAP-related protein IqgC is important for normal attachment of D. discoideum cells to the substratum. Mutant iqgC-null cells have impaired adhesion, whereas overexpression of IqgC promotes directional migration. A RasGAP C-terminal (RGCt) domain of IqgC is sufficient for its localization in the ventral adhesion focal complexes, while RasGAP activity of a GAP-related domain (GRD) is additionally required for the proper function of IqgC in adhesion. We identify the small GTPase RapA as a novel direct IqgC interactor and show that IqgC participates in a RapA-regulated signaling pathway targeting the adhesion complexes that include talin A, myosin VII, and paxillin B. On the basis of our results, we propose that IqgC is a positive regulator of adhesion, responsible for the strengthening of ventral adhesion structures and for the temporal control of their subsequent degradation.
Percutaneous closure of a traumatic ventricular septal defect: a case report and literature review
Authors: Calderon-Miranda Camilo Andres , Reyes-Cardona Maria Juliana , Lopez-Mora Gabriel Roberto , Guerrero-Pinedo Fernando Andrés , Sanchez-Blanco Jairo , Vesga-Reyes Carlos Enrique , Zambrano-Franco Jorge Alexander , Olaya Pastor 
Published: January 2025

Abstract
Background
Penetrating cardiac trauma is an entity with high pre and intrahospital mortality due to complications such as cardiac tamponade and massive hemothorax. A ventricular septal defect (VSD) occurs in 1–5% of cases and can present early or late. The management strategy for VSD resulting from penetrating cardiac trauma is uncertain.

Case presentation
A 19-year-old man was admitted in cardiorespiratory arrest after a precordial stab wound. Cardiopulmonary resuscitation was initiated achieving return of spontaneous circulation. eFAST evaluation revealed cardiac tamponade, he was taken to emergency left thoracotomy finding a perforation of the free wall of the left ventricle and a tear of the upper lobe of the left lung that were sutured. The patient was discharged and six days later was readmitted with fever and dyspnea. During treatment for a surgical site infection a new-onset pansystolic murmur was found: A transthoracic echocardiogram revealed a 13-mm VSD with left-to-right shunt. A multidisciplinary team recommended percutaneous closure of the defect which was successfully performed without complications.

Conclusions
Traumatic VSD is a rare complication of penetrating cardiac trauma. A thorough clinical and echocardiographic evaluation is essential for its diagnosis and characterization. Symptomatic septal defects, those 10 mm or larger, with Qp: Qs greater than 1.5, or causing complications such as pulmonary hypertension or valvular involvement, are usually closed to prevent progression of heart failure. Management of traumatic VSD has traditionally been surgical. However, a percutaneous intervention is a viable alternative in selected stable patients. Unlike ischemic VSD, early intervention after patient stabilization generally yields favorable outcomes.
Real-world evidence of remdesivir in formerly hospitalized COVID-19 patients: patient-reported and functional outcomes
Authors: Fésü Dorottya , Bárczi Enikő , Csoma Balázs , Polivka Lőrinc , Boga Márton , Horváth Gábor , Varga János Tamás , Sebők Szilvia , Müller Veronika 
Published: January 2025

Abstract
Background
Post-COVID condition (PCC) is characterized by persisting symptoms after the resolution of acute COVID-19. Remdesivir (RDV), a broad-spectrum antiviral drug, has been widely used in patients hospitalized with COVID-19 requiring oxygen therapy. We aimed to evaluate the effects of RDV on PCC by assessing patient-reported and functional outcomes.

Methods
We used the data from a single-center registry, including formerly hospitalized post-COVID patients (N = 293). Propensity score matching (PSM) was used (16 criteria, 1:1 ratio) to obtain two comparable groups: those who received standard-of-care (SOC, N = 94) and those treated with RDV in addition to SOC (SOC + RDV, N = 94). Primary outcomes were asymptomatic status and at least 50% symptom score reduction at post-COVID follow-up. Secondary outcomes included results of pulmonary function (PF) tests, 6-minute walk test (6MWT), and quality-of-life (QoL) questionnaires.

Results
After PSM, baseline patient characteristics showed no significant differences between the two groups. Most patients were still symptomatic (60% vs. 66%). In the SOC + RDV group, the use of oxygen supplementation (94 vs. 80%, p = 0.005) and steroids (97 vs. 88%, p = 0.027) during infection were higher, while patients presented at their post-COVID visits earlier (median 68 vs. 97 days, p = 0.003). Complete or at least 50% symptom resolution were reported at a significantly earlier stage after infection in the SOC + RDV group compared to the SOC group (multivariable-adjusted HR = 2.28, 95% CI = 1.33–3.92, p = 0.003; and HR = 2.08, 95% CI = 1.43–3.02, p < 0.001; respectively). In the SOC + RDV group, fewer patients experienced sleep disturbances at PCC, and sleep-related questionnaires (Pittsburg Sleep Quality Index, PSQI) results showed significantly better sleep quality (14 vs. 27% and 5.9 vs. 7.7 points, respectively). There were no notable differences in results of PF tests, 6MWT, and other QoL questionnaires.

Conclusion
In this propensity score matched cohort, the use of RDV was associated with earlier patient reported symptom resolution during the PCC period, while there were no notable differences in functional outcomes. Our results indicate a possible beneficial effect of RDV in terms of faster symptom resolution after COVID19 infection.

Graphical abstract
Intervention strategies to prevent mental health problems and improve resilience in employed parents from conception until the child is 5 years of age: a scoping review
Authors: Crombag Neeltje , Bollen Bieke , Vancoppenolle Eline , Vandendriessche Thomas , Versmissen Dagmar , Paisi Martha , Shawe Jill , Garthus-Niegel Susan , Bogaerts Annick 
Published: January 2025

Abstract
Aim
To understand the extent and type of evidence in relation to the effectiveness of intervention strategies targeting working pregnant women, and their partners, for the prevention of mental health problems (depression, anxiety) and improving resilience, from conception until the child is 5 years of age.

Methods
A scoping review was conducted searching Pubmed (including Medline), Embase, Web of Science Core Collection and Scopus. Inclusion criteria were based on population (employed parents), context (from -9 months to 5 years postpartum) and concept (mental health problems, resilience and prevention/ preventative interventions).

Results
Of the 17,699 papers screened, 3 full text papers were included. Studies focused on intervention strategies for working parents which showed a relationship with a reduction in mental health problems (depression and/or anxiety). The intervention strategies extracted from the literature referred to ‘social support’. Social support provided by both the social and the work environment correlated with prenatal stress and depressive symptoms in the postpartum period, and supports a healthy work-family balance.

Conclusion
Social support seems to have a positive association with the reduction of mental health problems. However, there are still important gaps in the literature such as a lack of RCT designs to test effectiveness of interventions and systematic reviews. Findings from this study may provide a roadmap for future research to close these gaps in knowledge.
An item response theory analysis of the Dissociative Experiences Scale II: examining psychometric properties and longitudinal stability among Japanese adults
Authors: Ikeda Tatsuya , Urano Yuhei 
Published: January 2025

Abstract
Background
The Dissociative Experiences Scale (DES-II) is widely used globally. However, psychometric properties of the scale have not been adequately examined. The present study aimed to examine the psychometric properties and longitudinal stability of the DES-II.

Method
We collected data at two time points, approximately three and a half years apart. At Time 1 (T1), 1029 participants (515 females, 514 males) with a mean age of 44.64 (± 14.02) responded to the survey. Out of the T1 participants, 210 individuals (105 females, 105 males) also responded to the T2 survey. We conducted item parameters of the DES-II with item response theory (IRT).

Results
Our results showed that the DES-II is suitable for measuring strong dissociative traits, with all items displaying high discriminative power. The cut-off points for the DES-II were within a good range of measurement accuracy, and longitudinal stability over approximately three and a half years was adequate.

Conclusion
In the present study, we applied item response theory (IRT) to the DES-II, which has traditionally been interpreted using classical test theory (CTT). Results suggested the need for item-focused assessment rather than relying solely on mean scores or cut-off points. Specifically, results suggested that the severity levels differed across item ratings, and to set cut-off points for each item based on the severity of the ratings. Furthermore, the possibility of cultural differences in response patterns of the DES-II was indicated. However, few studies have discussed cultural differences based on IRT; hence, further research should examine response patterns of the DES-II across various cultures. In conclusion, the DES-II is a valuable tool for assessing dissociative symptoms, with adequate psychometric properties from an item response theory perspective. Clinicians should consider item-specific responses in their assessments, and further research is needed to explore the scale's applicability across diverse populations.
Measuring a family sense of coherence: a rasch-based study extending dyadic data analyses
Authors: Möllerberg Marie-Louise , Årestedt Kristofer , Hagell Peter , Melin Jeanette 
Published: January 2025

Abstract
Background
Family sense of coherence (FSOC) seems to reduce distress in the family and promote the well-being of the family. Therefore, getting accurate measurements for families with long-term illnesses is of particular interest. This study explores dyadic data analysis from the dyadic- and single-informant perspectives, and the measurement properties of the FSOC-S12 according to the Rasch model.

Methods
Racked and stacked data from 151 dyads were analyzed according to the polytomous Rasch model.

Results
Notably, both the dyadic- and single-informant perspectives (i.e., racked and stacked data set-ups) showed measurement properties with minor deviations from the Rasch model according to fit statistics. However, most items had disordered thresholds and some problems with local dependency. Item hierarchies were similar in both set-ups and there was no differential item functioning (DIF) by role from the dyadic informant perspective. Four items showed DIF by informant role in the single-informant perspective.

Conclusions
Our approach to handling dyadic data has shown both strengths and limitations in the evaluation of FSOC-S12, and the understanding of FSOC as a construct from the family’s view of the family’s ability as a whole (dyadic-informant perspective) and patient’s and family member’s separate views of the family’s ability as a whole (single-informant perspective).
Learning from experience: does providing end-of-life care support for relatives boost personal end-of-life health literacy?
Authors: Meier Clément , Wieczorek Maud , Vilpert Sarah , Borrat-Besson Carmen , Jox Ralf J. , Maurer Jürgen 
Published: January 2025

Abstract
Background
Despite the critical role of health literacy in utilizing palliative care and engaging in advance care planning, limited research exists on the determinants of end-of-life health literacy. This study investigates the association between individuals’ experiences with end-of-life care support to relatives and their end-of-life health literacy among a population-based sample of adults aged 58 and older.

Method
We used data from 1,548 respondents in Switzerland to Wave 8 (2019/2020) of the Survey on Health, Ageing, and Retirement in Europe. Their ability to understand medical jargon, find information, communicate, and make decisions about end-of-life care options was measured with the validated Subjective End-of-Life Health Literacy Scale. Experiences with end-of-life care support include having made medical decisions as healthcare proxy, accompanied, or cared for relatives at the end of life. Associations were estimated using ordinary least squares regressions, controlling for socio-demographic, health, and regional characteristics.

Results
Respondents who experienced being a healthcare proxy (p < 0.001), who accompanied (p < 0.001), or who cared for a relative at the end of life (p < 0.001) tended to have higher levels of end-of-life health literacy. These results remained significant when the three variables were simultaneously included in the multivariable model (p < 0.001, p < 0.001 and p < 0.05).

Conclusions
Our findings suggest that providing end-of-life care support to relatives is associated with higher end-of-life health literacy. Thus, as caregivers gain experience caring for others, targeted interventions could leverage their skills and encourage them to think of engaging in end-of-life planning for themselves.
Explainable unsupervised anomaly detection for healthcare insurance data
Authors: De Meulemeester Hannes , De Smet Frank , van Dorst Johan , Derroitte Elise , De Moor Bart 
Published: January 2025

Abstract
Background
Waste and fraud are important problems for health insurers to deal with. With the advent of big data, these insurers are looking more and more towards data mining and machine learning methods to help in detecting waste and fraud. However, labeled data is costly and difficult to acquire as it requires expert investigators and known care providers with atypical behavior.

Methods
In this work we show how recent advances in machine learning can be used to set up a workflow that can aid investigators in discovering practitioners or groups of practitioners with unusual resource use in order to more efficiently combat waste and fraud. We combine three different techniques, which have not been used in the context of healthcare insurance anomaly detection: categorical embeddings to deal with high-cardinality categorical variables, state-of-the-art unsupervised anomaly detection techniques to detect anomalies and Shapley additive explanations (SHAP) to explain the model output.

Results
The method has been evaluated on providers with a known anomalous profile and with the help of experts of the largest health insurance fund in Belgium. The quantitative experiments show that categorical embeddings offer a significant improvement compared to standard methods and that the state-of-the-art unsupervised anomaly detection techniques generally show an improvement over traditional methods. In a practical setting, the proposed workflow with SHAP was able to detect a previously unknown, anomalous trend among general practitioners.

Conclusions
The proposed workflow is able to detect known care providers with atypical behaviour and helps expert investigators in making informed decisions concerning possible fraud or overconsumption in the health insurance field.
Evaluation of a national framework for rational use of medicines in Kazakhstan and its role in improving medicine use practices at the organizational and national levels
Authors: Zhussupova Gulzira , Aiypkhanova Ainur , Zhaldybayeva Saule , Satmbekova Dinara , Akhayeva Tamila , Kaliyeva Sholpan 
Published: January 2025

Abstract
Background
Kazakhstan inherited the Semashko health system model, known for the centralized adoption of rules at the Ministry of Health (MoH) level that regulate the healthcare system. In 2019 MoH established a national framework with indicators aimed at collecting qualitative and quantitative data from healthcare organizations as part of their annual self-evaluation, and biannual external evaluation by the National Research Center for Health Development (NRCHD). The purpose of this study was to pilot the MoH framework on rational use of medicines and evaluate its effects on medicine use practices in health care organizations and at the national level.

Materials and methods
This cross-sectional study was conducted from October to December 2019 at 22 state-owned primary health care organizations (polyclinics) serving adults and children in Astana, Kazakhstan. Data were collected by trained surveyors visiting each organization. Data were converted to numeric values to arrive at compliance scores for each organization and analyzed to assess each organization’s compliance with set indicators.

Results
The evaluation showed the rational use of medicines was assessed as “excellent” (90% < compliant) in 2 organizations (9% of the sample), “good” (75–89% compliant) in 7 organizations (32%), and “satisfactory” (50–74% compliant) in 13 organizations (59%), with an average compliance rate of 71% across the sample. 22 organization-specific evaluation reports were developed by the evaluator (NRCHD) and sent to health care organizations for corrective actions. Evaluation data triggered two improvements at the national level: correction of the default setting for trade names to international nonproprietary names within the physician ordering feature of the national health information system for medicines, and adoption of a national policy that allowed the exchange of unused stocks of medicines between polyclinics.

Conclusions
Using the national framework allowed the evaluator agency and healthcare organizations to identify organization-specific gaps and triggered improvements in the use of medicines.