bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF THE QUALITY OF VILLAGE-LEVEL CIVIL ADMINISTRATION SERVICES THROUGH THE POPULATION REGISTRATION INFORMATION SYSTEM (SIREP) BY THE TEGAL REGENCY CIVIL REGISTRY SERVICE
Authors: Novitaningrum Diah Ayu , Aji Arie Setianging , Salsabila Fadiya Hayya 
Published: January 2025

Public services provided by the government to the community must be adjusted to the conditions and needs of the community. The differences in conditions of the community results in diverse services provided by the government. Thus, the Tegal Regency Civil Registry Office made an innovation called the Sistem Informasi Registrasi Penduduk (SIPREP/Population Registration Information System). This research aims to find out about the service quality of civil administration services at the village level through SIREP. The research method used is qualitative descriptive with an inductive approach. The data collection techniques used were observation, interviews, and documentation. To analyze service quality, Sinambela’s theory was used with 6 dimensions of excellent service including transparency, accountability, conditional, participatory, equal rights, and balance of rights and obligations. Based on the analysys results, it was clear that the civil administration services at the village level through SIREP managed by the Tegal Regency Civil Registry Service had been running well. However, there were several inhibiting factors, namely limited human resources, lack of public awareness regarding orderly civil administration, and inadequate facilities and infrastructure in village offices so that services could not be provided in all villages in Tegal Regency.

Keywords: Services, Civil Administration, SIREP
THE EFFECTIVENESS OF THE FAMILY PLANNING PROGRAM IN CONTROLLING THE POPULATION GROWTH RATE IN NORTH MINAHASA REGENCY, NORTH SULAWESI PROVINCE
Authors: Sumual Rully , Poli Arnold , Basir Hestiwati , Pabisa Djonny 
Published: January 2025

This research aims to assess the effectiveness of the Family Planning Program in controlling the population growth rate in North Minahasa Regency, North Sulawesi Province. The research employs a qualitative descriptive method to collect and analyze data, with a total of 9 informants. Data collection was conducted through observation, interviews, and documentation. The data analysis process involved reduction, presentation, conclusion, and verification. The research is grounded in Duncan's theory of effectiveness, which consists of three components: (1) Goal Achievement, (2) Integration, and (3) Adaptation. The findings indicate that the Family Planning Program has effectively reduced the population growth rate in North Minahasa Regency by 0.6% compared to the previous year. The success of the program can be attributed to efforts to address various challenges, including enhancing human resource competency through training, conducting continuous socialization during key family-related events, and improving infrastructure, such as providing transportation to facilitate access to services for family planning participants.

Keywords: Effectiveness, Family Planning Program, Population Growth Rate
THE COMMUNICATION STRATEGY OF THE CIVIL SERVICE POLICE UNIT IN THE RELOCATION OF TRADERS AT ANYAR MARKET, TANGERANG CITY, BANTEN PROVINCE
Authors: Barokah Siti Ikpini Rizkiyatul , Aprimawati Baiq 
Published: January 2025

The objectives to be achieved in this study are to analyze and describe the Communication Strategy of the Tangerang City Civil Service Police Unit Banten Province to Anyar Market Traders; analyze and describe the supporting factors and inhibiting factors in the Communication Strategy of the Tangerang City Civil Service Police Unit Banten Province to Anyar Market Traders; analyze and describe the efforts that hinder the Communication Strategy of the Tangerang City Civil Service Police Unit Banten Province to Anyar Market Traders. The research design used is a qualitative descriptive approach, the data collection techniques used are interviews, documentation and observation. The theory used by the author is the theory of strategy according to James Briann Quin which has dimensions including goals, policies and programs. The results of the study show that the Communication Strategy of the Civil Service Police Unit in the relocation of Anyar Market traders in Tangerang City has been running well and succeeded in moving the Anyar market traders to the relocation site provided, this has been described in accordance with the dimensions and indicators of the theory that the author uses, by having a communication strategy used by the Tangerang City Government such as bidding, socialization and dialogue with Anyar Market Traders which is carried out in accordance with conditions in the field and prioritizes the common interest. The inhibiting factors are that the relocation places are far apart; the existence of provocateurs. Supporting factors are, 1) Good coordination and communication with the agencies involved such as PD. Market, Indagkop, Tangerang City Metro Police, Transportation Department, Environmental Service, Kesbangpol 2) have various ways to approach such as wawaran by notifying the Traders by using cars and loudspeakers for sounding related to relocation, socialization by providing direct understanding regarding the process of moving to the relocation site and dialogue with the Anyar Market Traders regarding the obstacles faced.

Keywords: Communication strategy; Civil Service Police Unit; Traders Relocation.
Formulation and Evaluation of Red Sweet Potato (Ipomoea batatas L.) Leaf Antidiabetic Capsules
Authors: Putri Lucienne Agatha Larasati Nugraha , Arisanti Cokorda Istri Sri , Dewi Ni Kadek Santi Maha , Wirasuta I Made Agus Gelgel 
Published: January 2025

Red sweet potato, or Ipomoea batatas L (IBL), has the potential to be developed as a herbal medicine to treat diabetes mellitus. Capsules were chosen for the formulation of IBL. The finished products are required to undergo a series of test in accordance with compendial standards and regulatory requirements for single-dose capsule products. To meet the quality and safety requirements of traditional medicines, efforts are needed to obtain an optimal capsule formula that ensures quality and safety. Mg stearate as a lubricant can be used to improve the flow properties of granules. The aims of this study are to formulate IBL into capsule dosage form and determine the influence of mg stearate in the formulation of IBL capsules. Two formulations were made using dry extract of IBL leaf (F1) and dry extract of IBL leaves with the addition of magnesium stearate (F2). The next stage was to evaluate the capsules with flowability parameters, including compressibility, weight uniformity and disintegration time. The next stage was to evaluate the capsules with several parameters, namely weight uniformity and disintegration time. The results obtained show that the F1and F2 capsule have met the quality and safety requirements set for traditional medicine preparations according to the quality and safety requirements of traditional medicine Compared to the formula without magnesium stearate (F1), the formula with magnesium stearate (F2) had a better compressibility index, which improved flowability, more uniformity of weight, and a longer disintegration time. However, there was no significant difference between the two formulas.
β-ecdysone/PLGA composite scaffolds promote skull defect healing in diabetic rat
Authors: Luo Yicai , Wu Ziwei , Zhang Yingjuan , Qiao Yang , Wei Yinge , Yan Xuan , Ma Xiangyu , Huang Xianxian , Zhong Xiaoxia , Ye Zhimao , Lu Xinping , Liao Hongbing 
Published: January 2025

IntroductionDiabetes mellitus often leads to bone metabolism disorders, hindering bone regeneration and delaying the healing of bone defects. β-Ecdysone, a plant-derived hormone known for its wide range of physiological activities, possesses hypoglycemic effects and promotes osteogenic differentiation. This study developed a composite PLGA slow-release scaffold loaded with β-ecdysone to enhance its bioavailability through topical administration and to investigate its potential to heal diabetic bone defects.MethodsThe composite scaffolds were fabricated using solution casting/particle leaching and freeze-drying techniques. Then a series of characterizations were subjected to test the performance of composite scaffolds, and in vitro safety of the composite scaffolds was tested by CCK8 assay and live/dead cell staining. Further, micro-CT and histology to evaluate the effect of β-E/PLGA composite scaffolds on healing of skull defects in diabetic rats at 4 and 8 weeks after implantation. Simultaneously, the safety of the scaffolds in vivo was also evaluated.ResultsThe material characterization results indicated that, in comparison to the single-pore size scaffold, the composite scaffold exhibited superior porosity, swelling ratio, drug loading capacity, and mechanical properties. Additionally, the composite scaffolds showed appropriate degradation performance and sustained drug release profiles. The CCK8 cytotoxicity assay and live/dead cell staining demonstrated that BMSCs survived and proliferated on the composite scaffold under both low-glucose and high-glucose conditions. Micro-CT and histological investigation demonstrated that β-E/PLGA composite scaffolds promoted new bone growth in the skull defect region of diabetic rats.ConclusionOverall, these findings suggest that the β-E/PLGA composite scaffolds promote the healing of bone defects in diabetic rats. The combination of β-ecdysone and tissue-engineered scaffolds presents a promising approach for treating diabetes-related bone defects.
Aspergillus identification through bronchoscope in intensive care unit – a retrospective, databased cohort study
Authors: Cheng Hsin-I , Lin Chun-Yu , Lin Horng-Chyuan , Lin Shu-Min , Hsieh Meng-Heng , Fang Yueh-Fu , Chang Po-Jui , Hung Wei-Syun , Cheng Ko , Huang Chung−Chi 
Published: January 2025

IntroductionInvasive pulmonary aspergillosis (IPA) increases the risk of mortality of critically ill patients. Diagnostic criteria specifically targeting patients in intensive care units(ICUs) have been developed to improve diagnostic sensitivity. This study investigated health outcomes among patients in ICUs with Aspergillus isolates identified using bronchoscopy.MethodsThis retrospective cohort study obtained data from the Chang Gung Research Database of Chang Gung Memorial Hospital. Patients admitted to the ICU between January 2017 and December 2022 who received bronchoalveolar lavage were enrolled. Patients with a fungus culture yielding Aspergillus spp. isolates or who had an Aspergillus galactomannan antigen index value of &gt;1.0 were categorized into the Aspergillus-positive group.ResultsA total of 2372 patients were enrolled, and 146 patients (6.16%) tested positive for Aspergillus. Of the patients who tested positive for Aspergillus, 37.67% had a positive culture result, and 77.4% had a positive galactomannan antigen result. Patients with Aspergillus isolates were more likely to have a recent influenza infection, concurrent bacterial sepsis, and a cavitation and to die in hospital (in-hospital mortality rate 58.9% vs. 48.57%, P = 0.016).DiscussionIdentifying Aspergillus through bronchoscopy in the ICU is associated with higher mortality rates than in patients who test negative for Aspergillus. Galactomannan antigen from bronchoalveolar lavage may provide higher diagnostic sensitivity.
Cardiac computer tomography-derived radiomics in assessing myocardial characteristics at the connection between the left atrial appendage and the left atrium in atrial fibrillation patients
Authors: Wei Xiao-Xuan , Li Cai-Ying , Yang Hai-Qing , Song Peng , Wu Bai-Lin , Zhu Fang-Hua , Hu Jing , Xu Xiao-Yu , Tian Xin 
Published: January 2025

ObjectivesTo evaluate the feasibility of utilizing cardiac computer tomography (CT) images for extracting the radiomic features of the myocardium at the junction between the left atrial appendage (LAA) and the left atrium (LA) in patients with atrial fibrillation (AF) and to evaluate its asscociation with the risk of AF.MethodsA retrospective analysis was conducted on 82 cases of AF and 56 cases in the control group who underwent cardiac CT at our hospital from May 2022 to May 2023, with recorded clinical information. The morphological parameters of the LAA were measured. A radiomics model, a clincal feature model and a model combining radiomics and clinical features were constructed. The radiomics model was built by extracting radiomic features of the myocardial tissue using Pyradiomics, and employing Least absolute shrinkage and selection operator (LASSO) method for feature selection, combining random forest with support vector machine (SVM) classifier.ResultsThere were 82 cases in the AF group [44 males, 65.00 (59, 70)], and 56 cases in the control group (21 males, 61.09 ± 7.18). Age, BMI, hypertension, CHA2DS-VASC score, neutrophil to lymphocyte ratio (NLR), LAA volume, LA volume, the myocardial thickness at the junction of LAA and LA, the area, circumference, short diameter, and long diameter of the LAA opening, were significantly different between the AF group and the control group (P &lt; 0.05). After conducting multivariate logistic regression analysis, it was found that BMI, the myocardial thickness at the junction of the LAA and the LA, LA volume, NLR and CHA2DS-VASC score were related to AF. 12 radiomics features of the myocardium at the junction of the LAA and the LA were extracted and identified. ROC curve analysis confirmed that the nomogram based on radiomics scores and clinical factors can effectively predict AF (AUC 0.869).ConclusionRadiomics enables the extraction of the myocardial characteristics at the junction of the LAA and the LA, which are related with AF, facilitating the assessment of its relationship with the risk of AF. The combination of radiomics with clinical characteristics enhances the evaluation capabilities significantly.
Prognostication in emergency room patients: comparing ultrasensitive and contemporary quantification of cardiac troponin levels below the 99th percentile
Authors: Carrasquer Anna , Cediel Germán , Gómez-Sanz Alma , Peiró Óscar M. , Fort-Gallifa Isabel , Bardaji Alfredo , Ferreiro Jose Luis 
Published: January 2025

IntroductionCardiac troponin levels below the 99th percentile improve the predictive efficacy for cardiovascular events when associated with relevant clinical variables. However, whether ultra-sensitive analytical methods improve this predictive efficacy over less sensitive or contemporary analytical methods remains unknown.MethodsThis retrospective observational study involved consecutive patients who presented to the emergency department for suspected acute coronary syndrome and underwent measurement of ultra-sensitive cardiac troponin I (Singulex) and contemporary cardiac troponin I (Siemens) with levels below the 99th percentile. The clinical characteristics of these patients were analysed, and the efficacy of both analytical methods for predicting cardiovascular events over a 4-year follow-up period was compared.ResultsIn total, 838 patients were analysed (mean age, 62.9 ± 16.6 years; 42.2% women). Their cumulative incidence of the composite cardiovascular event (death, readmission for myocardial infarction, and readmission for heart failure) was 25.9% over the 4-year follow-up. Both Singulex cardiac troponin I (analysed by quartiles) and Siemens cardiac troponin (analysed as detectable/undetectable) improved the predictive efficacy for the combined event over clinical variables [Harrell's C-index (95% confidence interval): 0.77 (0.74–0.80) vs. 0.79 (0.76–0.81) and 0.77 (0.74–0.80) vs. 0.78 (0.75–0.81), respectively; p = 0.018]. However, there were no statistically significant difference between the two predictive models that included the aforementioned troponin assays.ConclusionsDetectable levels of cardiac troponin using a contemporary analytical method or those near the 99th percentile using an ultra-sensitive analytical method improve the predictive efficacy for cardiovascular events, with no differences between the two methods
A comprehensive analysis of erectile dysfunction prevalence and the impact of prostate conditions on ED among US adults: evidence from NHANES 2001-2004
Authors: Zhang Yuhao , Zang Nan , Xiang Yingyue , Lin Fanlu , Liu Xue , Zhang Jing 
Published: January 2025

BackgroundErectile dysfunction (ED) is characterized by the inability to achieve or maintain penile erection sufficient for intercourse. While previous research suggests a potential link between ED and prostate pathologies, the association between benign prostatic hyperplasia (BPH), prostatitis, prostatic cancer (PCa), and ED remains to be elucidated.MethodsData from participants (40-80 years, n=2225) were extracted from the NHANES 2001-2004 for this observational study. The investigation encompassed the following aspects: assessment of ED prevalence within subgroups, comparison of baseline characteristics between individuals with and without ED, analysis of associations between BPH, prostatitis, PCa, and ED using multivariable weighted logistic regression in the 40-60 and 60-80 age groups and subgroup analysis based on body mass index, hypertension, diabetes, and smoking status.ResultsAmong the 2225 participants, the weighted prevalence of ED was 27.47%, with 16.17% in the 40-60 years age group and 56.98% in the 60-80 years age group. BPH had an ED prevalence of 47.57%, prostatitis 34.62%, and PCa 85.62%. Comparative analysis between ED and non-ED groups revealed significant differences in education levels, PIR, smoking and alcohol status, creatinine, total cholesterol, LDL cholesterol, diabetes, hypertension, BPH, and PCa. Multivariate logistic regression analysis identified BPH as an independent risk factor for ED in the 60-80 years age group (OR=1.93; 95% CI, 1.18-3.18, P=0.02), and PCa was positively associated with ED in both the 40-60 years group (OR=11.90; 95% CI, 1.41-100.50, P=0.03) and the 40-80 years group (OR=7.30; 95% CI, 2.12-25.08, P=0.01). No clear correlation was found between prostatitis and ED. Subgroup analyses indicated that the association between BPH and ED was significant in non-diabetic, overweight/obese, and smoking groups, while the association between PCa and ED was more pronounced in non-diabetic, hypertensive individuals across all body mass index (BMI) categories, and in both smoking and non-smoking groups. Prostatitis showed no significant relationship with ED in any subgroup.ConclusionThe study established BPH and PCa as significant risk factors for ED, with no substantial link detected between prostatitis and ED. This finding highlights the necessity for tailored screening and management protocols for individuals with BPH and PCa to mitigate the burden of ED.
Association between different insulin resistance indices and all-cause mortality in patients with diabetic kidney disease: a prospective cohort study
Authors: Zhu Huan , Chen Yinmei , Ding Dexin , Chen Hui 
Published: January 2025

AimPrevious research has shown a strong association between insulin resistance (IR) and both the onset and advancement of diabetic kidney disease (DKD). This research focuses on examining the relationship between IR and all-cause mortality in individuals with DKD.MethodsThis study utilized data obtained from the National Health and Nutrition Examination Survey (NHANES), spanning the years 2001 to 2018. Insulin resistance was assessed using reliable indicators (HOMA-IR, TyG, TyG-BMI, and METS-IR). The relationship between IR indices and survival outcomes was evaluated through weighted multivariate Cox regression, Kaplan-Meier survival analysis, and restricted cubic spline (RCS) modeling. To examine non-linear associations, the log-likelihood ratio test was employed, with piecewise regression models used to establish confidence intervals and identify threshold values. Diagnostic precision and efficacy were gauged using Receiver Operating Characteristic (ROC) curves, Area Under the Curve (AUC) evaluations, and calibration plots. Moreover, to verify the consistency of our results, stratified analyses and interaction tests were conducted across variables including age, gender, Body Mass Index (BMI), hypertension, and cardiovascular status.ResultsThis research involved a group of 1,588 individuals diagnosed with DKD. Over a median observation period of 74 months, 630 participants passed away. Using weighted multivariate Cox regression along with restricted cubic spline modeling, we identified non-linear associations between the four insulin resistance indices and all-cause mortality. An analysis of threshold effects pinpointed essential turning points for each IR index in this research: 1.14 for HOMA-IR, 9.18 for TyG, 207.9 for TyG-BMI, and 35.85 for METS-IR. It was noted that levels below these thresholds inversely correlated with all-cause mortality. In contrast, values above these points showed a significantly positive correlation, suggesting heightened mortality risks. The accuracy of these four IR metrics as indicators of all-cause mortality was confirmed through ROC and calibration curve analyses.ConclusionIn patients with DKD, an L-shaped association is noted between HOMA-IR and all-cause mortality, while TyG, TyG-BMI, and METS-IR exhibit U-shaped relationships. All four IR indices show good predictive performance.
Golgi protein 73: charting new territories in diagnosing significant fibrosis in MASLD: a prospective cross-sectional study
Authors: Hong Shan , Liu Ziyu , Li Ping , Zhang Jing , Wei Hongshan 
Published: January 2025

ObjectivesTo explore the correlation between serum Golgi protein 73 (GP73) levels and the degree of fibrosis in Metabolic dysfunction associated steatotic liver disease (MASLD); to establish a non-invasive diagnostic algorithm based on serum GP73 and liver elasticity.MethodsThis is a prospective cross-sectional study, including 228 patients diagnosed with MASLD from May 2018 to January 2024 at two tertiary hospitals. Clinical data and hepatic pathological features and the correlation between serum GP73 and liver fibrosis were assessed. A new algorithm was conducted after logistic regression. Receiver Operating Characteristic (ROC) curve was used to compare its diagnostic performance with traditional models.ResultsSignificant fibrosis was diagnosed in 37.2% (85/228) patients. Serum GP73 levels were markedly higher in patients with significant fibrosis than in those without (128 ng/mL v.s 46 ng/mL, p&lt; 0.001). Serum GP73 levels independently predicted significant liver fibrosis (adjusted odds ratio, aOR 1.028, p&lt; 0.001). A new algorithm based on GP73 was developed with a higher area under ROC (AUC) of 0.840 than that of Fibrosis index-4 (p&lt; 0.001).ConclusionsSerum GP73 is an independent risk factor for significant liver fibrosis in MASLD, and the GFA (GP73-Fibroscan-Age) model has good diagnostic efficacy for significant liver fibrosis.