bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Labels as Indicators of Tomato Freshness Using Mangosteen Peel Extract
Authors: Sari Vonny Indah , Susi Neng , Putri Vivin Jenika , Rahmah Anania , Rizal Muhammad 
Published: May 2023

Abstract
Tomato is one of the most popular tropical fruits because it tastes fresh and can be consumed directly or processed as a seasoning, garnish, and industrial raw material. Tomato cultivation is increasing with the increasing demand for tomatoes in the market. As a perishable product, many efforts have been made to maintain the quality of fresh tomatoes, one of which is by packing fresh tomatoes using innovative packaging. Smart packaging is packaging with an additional label to provide information to consumers without touching the product, so that product cleanliness is maintained. Several studies have added synthetic substances as smart labels, which will certainly have a negative impact on fresh products that are consumed directly. For this reason, smart labels were developed on packaging with natural ingredients taken from plant extracts. One that can be used as an indicator on a smart label is the rind of the mangosteen fruit. Mangosteen rind contains high anthocyanin substances, which are very sensitive to changes in pH. This situation can be used as an indicator of changes in pH that accompany a decrease in the quality of tomatoes during storage. This study aimed to determine the action of anthocyanin substances from mangosteen rind as a smart label indicator that detects the freshness of packaged tomatoes during storage, both at room temperature and cold storage.
An axisymmetric metal and metal-oxide grating-structured self-reference fiber optic SPR sensor
Authors: Kushwaha Anupam , Mishra Akanksha , Verma Roli 
Published: May 2023

Abstract
An optical-fiber-based surface plasmon resonance (SPR) sensing probe consisting of axisymmetrical grating is proposed and studied theoretically for the detection of the refractive index (RI). The sensing probe is formed by depositing a plasmonic metal layer on a bare core of optical fiber, followed by an axisymmetric grating layer and an analyte. The grating consists of metal and metal oxide in an alternate manner. The proposed structure of a single channel provides two resonance modes in the transmission SPR spectra. It is found that the mode present at the lower wavelength remains fixed, and the mode present at the higher wavelength is varied when the RI of the analyte is varied, so that the previous one works as a reference mode while the latter one works as a sensing mode. These properties provide the self-referencing capability of the proposed RI sensor in ambient conditions. We have calculated the sensitivity, detection accuracy (DA) and signal to width ratio (SWR) using the SPR spectra of various probes of different combinations of plasmonic metal and metal-oxide gratings to enhance the study. The best performing probe is found to be Ag/Cu-ITO. This optimum probe attained a maximum SWR of 42, sensitivity of 5400 nm RIU−1 and DA of 0.08 nm−1 with the self-referencing capability. The optimum probe also works well for a dispersive analyte within the spectral range. The use of metal oxide provides better adsorption of the analyte as well as high sensitivity. The cumulative properties of self-referencing and the metal oxide of the designed probe make it accurate and useful for the detection of biological elements in the ambient atmosphere.
Characterization of aperiodic surfaces with mesh-based parameters
Authors: Stöckel Stefanie , Segel Frank , Groeger Sophie 
Published: May 2023

Abstract
For technical surfaces, it is important to know their functional purpose and to characterize them accordingly. Therefore, ISO 21920–2 in 2D and ISO 25178–2 in 3D offer parameters that can assess surface functional properties. The topographic portions of a surface, for example hills and dales, can be classified as features and evaluated using feature parameters. However, no parameter exists to describe the spatial distribution of features with regard to the degree of homogeneity for aperiodic surfaces. Here we show the application of the Delaunay triangulation to quantify the spatial distribution respectively the geometric relationship of features. Therefore, the feature points are determined by watershed analysis and the resulting point cloud is meshed in 2D. Based on that mean and standard deviation of the triangle side lengths and the area disorder (AD) are calculated as new parameters. The method is demonstrated for sandblasted and chrome-plated specimens. In addition simulation is used to generate more data for analysis. With the proposed approach the distinction and extent of uniform, homogeneous or inhomogeneous spatial distributions of features with parameter AD can be determined.
Constitutive modeling for elevated temperature flow behavior of a novel Cr-Si alloyed hot stamping steel
Authors: Zhu Rong , Yang Xiaoyu , Mi Zhenli , Jiang Haitao , Yang Yonggang , Wang Mai , Zhang Qi , Wu Yanxin , Li Lei 
Published: May 2023

Abstract
The flow behavior of a novel Cr-Si alloyed hot stamping steel (Cr-Si steel) at elevated temperature was investigated via isothermal compression tests on a Gleeble-3500 thermomechanical simulator with a temperature range of 600 ∼ 900 °C and a strain rate range of 0.1 ∼ 10 s−1. Subsequently, the Arrhenius-type constitutive model, comprising strain compensation, was established in accordance with the friction and adiabatic heating corrected stress-strain curves. Furthermore, the predictability and prediction accuracy of the constitutive model were verified. The results reveal that at a constant strain rate, the flow stress of the Cr-Si steel initially increases as the strain increases before tending to stabilize, owning to the combined effects of work hardening and dynamic recovery. The peak flow stresses decrease as the temperatures increase and the strain rates decrease. The constitutive model can accurately predict the elevated temperature constitutive relationship of the Cr-Si steel during the hot stamping process.
Functional properties of Sr1-xGdxTiO3 ceramics synthesized by solid state reaction method
Authors: Alshoaibi Adil , Bhellar Ikhtiar Hussain , Hussain Fayaz , Zubairi Hareem , Shaikh Sajida , Faouri Sinan 
Published: May 2023

Abstract
Sr1-xGdxTiO3 (0.00 ≤ x ≤ 0.11) ceramics by the addition of Gd3+ on A-sites, were processed and fabricated through the conventional sintering method and optimised the sintering temperature at 1390 °C–1470 °C for 2 h. The experimentation shows that all ceramics are possessed by cubic structure, in which the increment of Gd3+ content, in terms of x, decreases the lattice parameters of the ceramics, as well as affects the grain size. Comparing the results to pure SrTiO3 (STO) compounds, the addition of Gd3+ lowers the mass loss, increased the conductivity as well as permittivity by decreasing the dielectric losses at lower frequencies. The x = 0.03 and 0.01 evidenced the maximum Seeback Coefficient, ∼281 μV K−1 at ∼370 K confirming the higher carrier concentration. Also, the magnetic properties as a function of Gd3+ ions doped with STO showed gradual improvement, showing maximum saturation with the maximum concentration of x.
Immersion vs. Engaged Interactivity in The Autobiography of Jane Eyre’s Storyworld; Or What We Can Learn from Paratextual Traces
Authors: Oestreich Kate Faber 
Published: May 2023

Abstract
This paper uses The Autobiography of Jane Eyre (Nessa Aref and Alysson Hall’s 2013–2014 transmedia adaptation of Charlotte Brontë’s Jane Eyre, hereafter AoJE) to explore the impact of characters’ social media accounts on user interactivity and immersion. AoJE employs the powers of social media to create a modernized and fully-fledged storyworld, yet the users’ overall experience is undermined by the very strategies meant to facilitate engaged interactivity. When social media posts become sites where users not only actively seek additional content but also ‘read’ traces of other users’ interactions with the content, those traces function as paratextual commentary, creating dialogic metaphors. In AoJE, the characters’ social media accounts demand that users remain in a near constant state of metalepsis by accepting and even inverting several previously accepted ontological binaries: character/actor, reader/writer, passive/active, immersive/interactive. The effort required by users to interact successfully with the various platforms additionally underscores the difficulty of consuming (and prosuming) a story that unfolds over multiple platforms, especially once the social media components no longer exist in the immediate present.
Laboratory-Developed Tests Account for a Small Minority of Tests Ordered in an Academic Hospital System
Authors: Rychert Jenna , Schmidt Robert L , Genzen Jonathan R 
Published: May 2023

Abstract

Objectives
To determine the frequency of use of laboratory-developed tests (LDTs) in an academic medical center system.

Methods
Retrospective analysis of 2021 test order data from an academic medical center (hospital, outpatient clinics, and cancer center) was done. Measures included assay type, assay methodology, regulatory status, test order volume, inpatient vs outpatient setting, and provider medical specialty.

Results
Of the 3,016,928 tests ordered in 2021, 2,831,489 (93.9%) were tests cleared, approved, and/or authorized by the US Food and Drug Administration (FDA); 116,583 (3.9%) were LDTs; and 68,856 (2.3%) were standard methods. These test orders were performed using a total of 1,954 distinct assays. Of these, 983 (50.3%) were FDA assays, 880 (45.0%) were LDTs, and 91 (4.7%) were standard methods. Laboratory-developed tests were more commonly ordered in the outpatient vs inpatient setting and represented a higher proportion of the test volume at the cancer center compared with the university hospital (5.6% vs 3.6%, respectively). The top 167 LDT assays accounted for 90% of the LDT volume (104,996 orders). Among the 20 most frequently ordered LDTs were mass spectrometry assays and tests used in the care of immunocompromised patients. Internal/family medicine placed the greatest number of orders (1,044,642) and ordered one of the lowest proportions of LDTs (3.2%).

Conclusions
Laboratory-developed tests made up a small percentage of the total laboratory tests ordered within the academic health system studied.
DBGRU-SE: predicting drug–drug interactions based on double BiGRU and squeeze-and-excitation attention mechanism
Authors: Zhang Mingxiang , Gao Hongli , Liao Xin , Ning Baoxing , Gu Haiming , Yu Bin 
Published: May 2023

AbstractThe prediction of drug–drug interactions (DDIs) is essential for the development and repositioning of new drugs. Meanwhile, they play a vital role in the fields of biopharmaceuticals, disease diagnosis and pharmacological treatment. This article proposes a new method called DBGRU-SE for predicting DDIs. Firstly, FP3 fingerprints, MACCS fingerprints, Pubchem fingerprints and 1D and 2D molecular descriptors are used to extract the feature information of the drugs. Secondly, Group Lasso is used to remove redundant features. Then, SMOTE-ENN is applied to balance the data to obtain the best feature vectors. Finally, the best feature vectors are fed into the classifier combining BiGRU and squeeze-and-excitation (SE) attention mechanisms to predict DDIs. After applying five-fold cross-validation, The ACC values of DBGRU-SE model on the two datasets are 97.51 and 94.98%, and the AUC are 99.60 and 98.85%, respectively. The results showed that DBGRU-SE had good predictive performance for drug–drug interactions.
Medication adherence in relation with physical activity in hypertensive patients : data from a behavioral cardiology unit
Authors: Fragoulis C , Prentakis A G , Kontogianni E , Polyzos D , Tsioufis P A , Fragouli D , Leontsinis I , Mantzouranis E , Sakalidis A , Mavroudis A , Kalos T , Chrysochoou C , Politis A , Tsioufis K P 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background/Introduction
Few studies have examined the relationship between exercise and adherence to antihypertensive medication, examining all possible factors contributing to blood pressure control.

Purpose
The purpose of our study was to access the possible dependence relationship among hypertensive patients visiting the Behavioral Cardiology Unit in a Tertiary Hospital.

Methods
The study population consisted of patients reporting to the Behavioral Cardiology Unit in a Tertiary Hospital during a period of 6 months in 2021. In terms of holistic approach, all patients underwent a thorough clinical in-depth interview, using the Morisky Medication Adherence Scale (MMAS8), the Frail Questionnaire Screening Tool (Frailty Score) and the Patient Health Questionnaire-4 (PHQ-4). All patients also provided full history of exercise (at least 150 minutes of physical activity or 75 minutes of intense activity per week), while completing the Duke Activity Status Index (DASI).

Results
The population consisted of 42 hypertensive patients, 54.8% of them were females, with a mean age of all patients at 55.8±15.2 years. Body Mass Index was averaging at 27.6 kg/m2. Salt consumption above the daily suggested amount (&gt;5gr/day) was reported by 60% of patients, binge drinking by 43% of them, while 43% had a history of active smoking. High adherence was reported by 17 patients (46%), medium adherence by 14 (37.8%) and low adherence by 6 (16.2%). Results indicate a relationship between exercise and adherence to medication. More specifically, Chi-Square test showed statistical significance between exercise and medium medication adherence in MMAS8 (MMAS8: 6-7, p=0.033). Moreover, statistical analysis showed significant relationship between exercise, frailty and PHQ-4 score. Particularly, patients with absence of exercise showed higher level of PHQ-4 score (F=7.07, p=0.011).

Conclusions
Our study highlights the possible dependency relationship of exercise and adherence to medication. Results indicate that patients with good adherence to medication have better behavioral activation. There is need for further research in this domain, to confirm the findings.
Usefulness of heart failure categories based on left ventricular ejection fraction
Authors: Christersson M , Gustafsson S , Lampa E , Almstedt M , Cars T , Arefalk G , Sundstrom J 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Private company. Main funding source(s): This study was sponsored by AstraZeneca.

Introduction
Heart failure, a common disease with a mortality on par with many cancers, is one of the costliest diseases to society in the western world. Current heart failure guidelines are based on categories of left ventricular ejection fraction (LVEF) and have recently introduced a narrow category with mid-range/mildly reduced ejection fraction (HFmrEF; LVEF 41-49%) between the previous categories with reduced (HFrEF; LVEF ≤40%) and preserved (HFpEF; LVEF ≥50%) ejection fraction. The grouping of continuous variables into narrow categories can be questioned if the variability is high.

Purpose
To determine the shape of the LVEF distribution and quantify the stability of LVEF categories over time in a large real-world heart failure population, in order to establish the usefulness of LVEF categories for treatment decisions.

Methods
Population-based observational cohort study of all new cases of chronic heart failure in Region Stockholm, Sweden, from 2016-01-01 until 2020-12-31. All available values of LVEF were collected over time and patients were followed until death or end of study. Mixed models were used to quantify within-person variance in LVEF, and Multistate Markov models, with death as an absorbing state, to quantify the stability of LVEF categories.

Results
During the study period, 8,455 patients were diagnosed with heart failure. LVEF values followed a perfect normal distribution. The standard deviation of the within-person variance in LVEF was 7.4%. Regardless of initial LVEF category, age or sex, the mean time spent in any LVEF category before transition to another category (mean sojourn time) was on average less than 0.6 years (Figure 1). The one-year probabilities of transitioning between states were substantial (Figure 2). Patients with HFmrEF had a probability of 1/4 of remaining in that category one year later; the probability of patients with HFrEF of remaining in that category one year later was 1/4 for women and 1/3 for men; and patients with HFpEF had a probability of remaining in that category of 2/3 for women and 1/2 for men.

Conclusion
In patients with heart failure, LVEF has considerable variability over time. Hence, LVEF has limited use for categorisation of the heart failure population into narrow categories.
Effects of physical exercise on health-related quality of life in coronary heart disease patients. a systematic review and meta-analysis
Authors: Toval A , Bakker E A , Granada-Maia J B , Nunez De Arenas-Arroyo S , Solis-Urra P , Molina-Garcia P , Eijsvogels T M H , Martinez-Vizcaino V , Esteban-Cornejo I , Ortega F B 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): - HEARTY-BRAIN - Effects of Exercise on Brain in Patients with Coronary Heart Disease: The Heart-Brain Connection. Andalusian Plan for Research Development and Innovation (PAIDI). University of Granada. Funding: 116.000 €. PI: F. Ortega. 2021-2021. - VASCULACTIVE. Effects of exercise on brain vascularization in coronary heart disease patients. Spanish Ministry of Economy and Competitiveness (I+D+I RETOS). University of Granada. Funding: 121.000 €. PI: F. Ortega. 2021-2023.

Background
Coronary heart disease (CHD) is the most prevalent type of cardiovascular disease in the world, and a leading cause of mortality and morbidity. Previous research showed that patients with CHD have a decrease in health-related quality of life (HRQoL) during the course of the disease. Physical exercise may attenuate the decline in HRQoL observed in CHD patients.

Purpose
To determine the effect of exercise training interventions on HRQoL in CHD patients.

Methods
A systematic search of controlled trials (CTs) assessing the effects of exercise training on HRQoL in CHD patients was performed in Web of Science, PubMed, Scopus, EMBASE, Cochrane Register, SportDiscus, PsycINFO and Google Scholar from inception to 30 June 2022. A meta-analysis with fixed and random effects was performed on controlled trials (comparing at least one exercise group with one non-exercise group and including a global score of HRQoL assessments before and after the interventions. All statistical analyses were performed using R-Studio.

Results
A total of 26 CTs met all the eligibility criteria and were included in the review (25 randomized CTs and 1 non-randomized CTs). HRQoL was mostly assessed by the SF-36 instrument (11/26) and the MacNew Heart Disease Health-Related Quality of Life questionnaire (8/26). Six out of the 26 studies reported the total score of quality of life and were included in the meta-analysis, which resulted in 8 exercise interventions and 591 participants with a mean age of 61 years, and 33% was women. There was a small (effect size 0.20) borderline overall effect of exercise on HRQoL in CHD patients (95% confidence interval: fixed effect, 0.05–0.36; random effect, -0.06-0.46. The percentage of total variability attributed to between-study heterogeneity [I2] = 44%, P=0.09 (Figure 1).

Conclusions
Findings from this meta-analysis suggest that supervised exercise training may cause a modest improvement in HRQoL in CHD patients. Future studies should explore which type and loads of exercise lead to larger improvements.
Left atrial strain significance in prediction of early atrial fibrillation recurrence after cardioversion and ablation
Authors: Sabanovic-Bajramovic N , Iglica A , Begic E , Begic A , Dzubur A , Naser N , Bajramovic S 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
The fibrosis of the LA, which is characteristic of AF, causes mechanical dysfunction of the LA and may also be present in patients without LA enlargement. LA strain represents a surrogate marker of this mechanical dysfunction. Early detection of LA dysfunction may be crucial in identifying patients who are more likely to experience AF recurrence following cardioversion and ablation. Before cardioversion and ablation, the probability of AF recurrence might be predicted, which could lead to better patient selection, an individualized therapeutic strategy with reduced risk and focused follow-up.

Purpose
The aim of this study was to evaluate the additional predictive value of LA function assessed by using strain echocardiography for early AF recurrence after cardioversion and ablation.

Methods
94 patients diagnosed with symptomatic persistent atrial fibrillation (EHRA symptom score ≥3 (mean age 59.4 ± 12.2 years, 58% male, 42%female), preserved LV ejection fraction were prospectively analyzed. In 39 (41,5%) patients pharmacological cardioversion was done after saturation with antiarhythmic drugs,in 27 (28,7%) patients planed electrical cardioversion was done after medical saturation with antiarrhythmic drugs and failure of pharmacological cardioversion, and in 28 (29,8%) patients planed RF ablation was performed. Complete echocardiography evaluation including strain and volume index LA was performed before cardioversion and ablation. The rhythm evaluation was done in the first month after cardioversion and RF ablation (35±5 days). The primary endpoint was persistent AF recurrence.

Results
29 (30,8%) patients had AF recurrence in the overall study population, independently of duration of AF or method of rhythm control. Peak atrial longitudinal strain (PALS) ≤15% had the highest incremental predictive value for AF recurrence (HR =8.42, 95% CI: 3.17–25.12, p &lt; 0.001). In patients with non-dilated LA, PALS≤15% remained an independent predictor of AF recurrence (HR = 5.32, 95% CI: 1.77–17.42, p = 0.005).

Conclusion
This study shown that, in addition to LA dilatation, LA function as determined by PALS can provide a prognostic value for early AF recurrence after cardioversion or ablation. PALS also predicted AF recurrence in patients with nondilated LA. These findings highlight the additional prognostic usefulness of LA strain and recommend its implementation in the systematic assessment of AF patients prior to the choice of rhythm/rate control.