bluuebunny/crossref_metadata_2025_split huggingface dataset:
Khảo sát ảnh hưởng của các chất ổn định tới cấu trúc, màu sắc của sản phẩm sốt cà chua sấy dạng miếng
Authors: Nguyễn Thị Minh Thôi 
Published: February 2023

Những sản phẩm cô đặc từ cà chua ở nước ngoài phát triển rất mạnh, tuy nhiên sốt cà chua sấy dạng miếng có thể sử dụng trong các sản phẩm hamburger, pizza…rất tiện lợi và tạo cảm giác thơm ngon cho người dùng thì chưa có trên thị trường. Để có quy trình chế biến sốt cà chua sấy dạng miếng với cấu trúc, màu sắc và chỉ tiêu cảm quan của sản phẩm đáp ứng nhu cầu người tiêu dùng, các chất tạo cấu trúc pectin, carboxymethiylcellulose (CMC), xanthan gum, tinh bột biến tính (TBBT) được xác định qua các tỷ lệ khác nhau nhờ phương pháp đo cấu trúc, đo màu sắc sản phẩm và phương pháp đánh giá cảm quan. Kết quả cho thấy sản phẩm sử dụng TBBT có cấu trúc mềm nhất so với các chất còn lại. Màu sắc sản phẩm sau 14 ngày bị kích thích dưới điều kiện ánh sáng ở nhiệt độ 40 ± 1oC cho thấy các chỉ số về màu sắc của sản phẩm giảm dần qua thời gian kích thích, trong đó mẫu sử dụng pectin là chất có khả năng giữ màu của sản phẩm tốt hơn so với các chất còn lại. Đánh giá cảm quan bằng phương pháp so hàng mẫu sử dụng TBBT cũng có độ mềm dẻo vừa phải nhất và các chỉ tiêu về màu sắc và cảm quan đều được đánh giá tốt. Vì vậy, chọn mẫu bổ sung TBBT (1%) cho quy trình chế biến sốt cà chua sấy dạng miếng
Burden in caregivers of children with congenital Zika syndrome in Pernambuco, Brazil: analysis and application of the Zarit burden interview scale
Authors: Rego Filho Jerônimo Faustino , Sena Claudia , Wajnsztejn Rubens 
Published: February 2023

With the increase in cases of microcephaly caused by the Zika virus, the demand for special care and a better quality of life for the child and caregiver increased proportionally.

Objective
This study aimed to analyze the burden on caregivers of children with congenital Zika syndrome associated with viral infections in the state of Pernambuco, Brazil using the Zarit Burden interview scale.

Method
A quantitative study was conducted at the Oswaldo Cruz University Hospital, Recife City, State of Pernambuco, Brazil. By convenience sampling, 56 mothers, two grandmothers, and two caregivers were enrolled, all are female. Data were collected from July 2019 to January 2020. In the analysis, the percentage frequencies were calculated. The normality was identified using the Kolmogorov–Smirnov test, and participant profiles were compared using Student’s t-test and analysis of variance. In descriptive statistics, quantitative variables are described by the median and interquartile range and categorical variables by proportions using the Chi-square test.

Results
In the comparative analysis, all factors evaluated were significant, except for the “gestational period in which the disease occurred” (p < 0.111). The significance of differences in all activities was evaluated. In the mean comparison test, only the factor “has a job” was significant (p < 0.043). When comparing the average of caregivers’ responses to the categories of the Zarit burden interview scale, the highest level of burden was regarding the feeling that the child is dependent on the caregiver (3.62 points). Caregiver burden was classified as absence, light, moderate, and high.

Conclusion
The consequences of contracting the Zika virus in the first trimester of pregnancy, lack of paid work, financial scarcity, full-time dedication to the child, and lack of time for themselves increase the burden on caregivers. Thus, caregivers have mild burden.
High-throughput Treg cell receptor sequencing reveals differential immune repertoires in rheumatoid arthritis with kidney deficiency
Authors: Zhang Lu , Jiao Wei , Deng Hui , Hu Congqi , Xu Jia , Yu Jiahui , Liu Lijuan , Zhang Mingying , Liu Jiduo , Chen Guangxing 
Published: February 2023

Background
Regulatory T (Treg) cells are important immune cells that are regulated by adaptive immunity in the composition of Treg-cell subsets and T-cell receptors (TCRs). Treg cells are related to most autoimmune diseases, such as rheumatoid arthritis (RA). In traditional Chinese medicine (TCM), RA is typically attributed to kidney deficiency (KD) associated with the immunosenescence that causes immune dysfunction and the impaired function of Treg cells. So far, however, no mechanism related to KD and immune repertoires has been identified in RA.

Methods
Flow cytometry and high-throughput Treg-cell receptor sequencing were used to investigate the amount of different Treg-cell subsets and the diversity of TCRs between RA patients and healthy subjects, as well as between KD RA and non-KD RA patients. RT-qPCR was used to validate the high-throughput sequencing results.

Results
The data showed that the amount of naïve Treg cells in KD patients was less than in non-KD RA patients (P = 0.004) with no significant differences observed between other subsets. In the TCR of Treg cells, the length of complementarity determining region 3 (CDR3) was low and clonotypes increased in the KD group compared with the non-KD group. The diversity and abundance of Treg TCRs were low, as determined by the Hill number. In addition, several V(D)J combinations, such as T-cell receptor beta variable 7-2 (TRBV7-2), TRBV11-1, TRBV13, TRBV15, and TRBJ2-3, varied significantly between the two groups, indicating that KD causes Treg dysfunction. RT-qPCR shows that FOXP3 expression in peripheral blood Treg is lower in KD than in non-KD.

Conclusion
The results demonstrate the close correlation between KD and immune repertoires in RA and provide a new evaluation method for RA in TCM.
Utility of Trichoderma Amended Compost to Manage Soil Borne Fungal Diseases of Vegetable Crops in Kota District of Rajasthan (India)
Authors: Sharma Lalita , Shrivastava Pratima 
Published: February 2023

In the present research article, Trichoderma species was isolated and multiplied on a growth medium without contamination for compost preparation. The aim of this study was detecting organic substrates of Trichoderma spp. for their antagonistic ability, for this purpose six major agricultural fields of Kota district are selected , from each field about 3-3 samples of soil are collected to detect the percentage of fungal disease incidence and tricho-compost was applied over diseased plants to minimize the fungal attack over vegetable crops. It was observed that the disease incidence is minimized by using tricho-compost mixed with soil in Gopalpura and Balita Village.
The Association between Socio-demographic Factors and the Six Protective Factors that Foster Resilience among Tanzania Primary Schools Teachers
Authors: Habibu Baruani Twalibu , Li Xinyu , Sun Qian 
Published: February 2023

Stress has been counted as a major problem for many teachers; something led some of them to have ineffective job performance within teaching profession. This study designed to examine the association between socio-demographic factors and the six protective factors that foster resilience among Tanzania primary schools teachers. And it was guided by a research question which stated that how have socio-demographic factors associated with six protective factors that foster resilience among Tanzania primary schools teachers?
A total numbers of participants who filled and completed questionnaires were six hundred sixty two. The questionnaire had 36 items measuring six protective factors strongly associated with resiliency within teachers. And it was a Likert Scale ranged from strongly agree to strongly disagree. The six protective factors are such as purpose & expectations (PE), nurture & support (NS), positive connections (PC), meaningful participation (MP), life guiding skills (LGS), and clear & consistent boundaries (CCB).
Confirmatory Factor Analysis (CFA) was applied since we wanted to confirm the usability of scale items to Tanzania primary schools teachers. Basic descriptive statistics such as frequency, percent mean and standard deviation were calculated and used to describe the sample and the characteristics of the respondents. And since resilience of every domain was continuous variables multiple linear regression analysis was performed to determine association of resilience of every domain.
The results of this study show that to a large extent these six protective factors have a great contribution in promoting resilience to primary schools teachers in Tanzania. The factors have been different in developing the level of resilience for the respective teachers according to the environment in which the teachers work in, something leads to different responses for each socio-demographic factors used in this study.
Discriminant Function Analysis of Mandibular Condyle and Notch for Sex Determination
Authors: E. Edet Iboro , Olotu E. J. , Edibamode E. I. 
Published: February 2023

Aim: This research aimed at deriving discriminant function equation from Bicondylar Braedth (BCB) and mandibular Notch Breadth (MNB) for sex determination.
Study Design: A cross-sectional descriptive study was adopted for this research.
Place and Duration of Study: BCB and MNB measurements were obtained from 13 universities across South – South, South – East, North Central and South – west geo – political zones in Nigeria from January to June 2021.
Methodology: BCB and MNB were measured from 52 males and 30 females mandibles using vernire caliper. Data obtained were analyzed using SPSS IBM version 23.0.
Results: Descriptive analysis of BCB showed higher mean values for males 115.46mm compared to females 107.78mm; while MNB showed a higher mean value for females 25.00mm compared to males 24.41mm. Independent t-test analysis of the parameters showed BCB had significant sexual difference while MNB did not show significant sexual difference at 95% confident interval. The discriminant function analysis of BCB well discriminated sex and after cross-validation, BCB accurately predicted 82.7% males and 56.7% females but MNB could not discriminate sex.
Conclusion: BCB is a reliable parameter for sex determination which is fundamental in forensic investigation whereas MNB is not suitable for sex determination.
Comparing the Hospital Frailty Risk Score and the Clinical Frailty Scale Among Older Adults With Chronic Obstructive Pulmonary Disease Exacerbation
Authors: Chin Melanie , Kendzerska Tetyana , Inoue Jiro , Aw Michael , Mardiros Linda , Pease Christopher , Andrew Melissa K. , Pakhale Smita , Forster Alan J. , Mulpuru Sunita 
Published: February 2023

ImportanceFrailty is associated with severe morbidity and mortality among people with chronic obstructive pulmonary disease (COPD). Interventions such as pulmonary rehabilitation can treat and reverse frailty, yet frailty is not routinely measured in pulmonary clinical practice. It is unclear how population-based administrative data tools to screen for frailty compare with standard bedside assessments in this population.ObjectiveTo determine the agreement between the Hospital Frailty Risk Score (HFRS) and the Clinical Frailty Scale (CFS) among hospitalized individuals with COPD and to determine the sensitivity and specificity of the HFRS (vs CFS) to detect frailty.Design, Setting, and ParticipantsA cross-sectional study was conducted among hospitalized patients with COPD exacerbation. The study was conducted in the respiratory ward of a single tertiary care academic hospital (The Ottawa Hospital, Ottawa, Ontario, Canada). Participants included consenting adult inpatients who were admitted with a diagnosis of acute COPD exacerbation from December 2016 to June 2019 and who used a clinical care pathway for COPD. There were no specific exclusion criteria. Data analysis was performed in March 2022.ExposureDegree of frailty measured by the CFS.Main Outcomes and MeasuresThe HFRS was calculated using hospital administrative data. Primary outcomes were the sensitivity and specificity of the HFRS to detect frail and nonfrail individuals according to CFS assessments of frailty, and the secondary outcome was the optimal probability threshold of the HFRS to discriminate frail and nonfrail individuals.ResultsAmong 99 patients with COPD exacerbation (mean [SD] age, 70.6 [9.5] years; 56 women [57%]), 14 (14%) were not frail, 33 (33%) were vulnerable, 18 (18%) were mildly frail, and 34 (34%) were moderately to severely frail by the CFS. The HFRS (vs CFS) had a sensitivity of 27% and specificity of 93% to detect frail vs nonfrail individuals. The optimal probability threshold for the HFRS was 1.4 points or higher. The corresponding sensitivity to detect frailty was 69%, and the specificity was 57%.Conclusions and RelevanceIn this cross-sectional study, using the population-based HFRS to screen for frailty yielded poor detection of frailty among hospitalized patients with COPD compared with the bedside CFS. These findings suggest that use of the HFRS in this population may result in important missed opportunities to identify and provide early intervention for frailty, such as pulmonary rehabilitation.
Most-Cited Patient-Reported Outcome Measures Within Otolaryngology—Revisiting the Minimal Clinically Important Difference
Authors: Peterson Andrew M. , Miller Brevin , Ioerger Patrick , Hentati Firas , Doering Michelle M. , Kallogjeri Dorina , Piccirillo Jay F. 
Published: February 2023

ImportancePatient-reported outcome measures (PROMs) allow clinicians and researchers to assess health-related information from a patient’s perspective. These measures have been used more frequently over the last several decades, but an associated minimal clinically important difference (MCID) is needed to optimize their utility. This narrative review identified the top 100 most-cited otolaryngology-related PROM development and validation publications and assessed the presence and characteristics of the PROMs’ associated MCID.ObservationsIn this narrative review, a literature search in Scopus and Web of Science was conducted on June 29, 2022, using keywords related to PROM development and validation studies in otolaryngology and reference lists. Studies that met the definition of a PROM and assessed an otolaryngologic disorder or study population were included for full-text review. After full-text review of 188 articles, the top 100 most-cited PROM development and validation publications, resulting in 106 total PROMs, were chosen for review. A total of 39 (37%) of the identified PROMs had an associated MCID. Of those reporting an MCID, 14 (35.9%) used an anchor-based method, 12 (30.8%) used a distribution-based method, 10 (25.6%) used both, and 3 (7.7%) did not specify or used neither method. Rhinology had the greatest number of PROMs with an associated MCID (16 of 24, 66%), and pediatrics had the fewest (1 of 13, 7.7%). The median number of citations of PROMs with an MCID was higher than those without an MCID.Conclusions and RelevanceThe majority of the most-cited PROMs in otolaryngology lack an associated MCID. These data indicated that there are a multitude of PROMs that have been cited hundreds of times and used for decades without the ability to identify whether a particular change in score on the instrument is clinically meaningful. There is a need to determine and validate MCIDs for commonly used PROMs to aid clinical research and trial interpretation.
Assessment of ultrasound shear wave elastography: An animal ex‐vivo study
Authors: Wang Xiuming , Zhu Jiaan , Liu Yiqun , Li Wenxue , Chen Si , Zhang Huabin 
Published: February 2023

AbstractObjectivesTo explore the influence of the surrounding environment of the target tissue, lesion size, and rectangular sampling box size on shear wave speed (SWS).MethodsThe tendon SWS was acquired ex‐vivo. Then the tendons were dissected and buried in the couplant (gel) and evaluated by two‐dimensional shear wave elastography (2D‐SWE). Finally, the tendons were placed in the isolated muscles to simulate the intramuscular lesions, and their elasticity was tested under two rectangular sampling box conditions. The isolated complete liver SWS was acquired. Similarly, the large and small pieces of livers were cut out, placed in the muscles, and assessed by SWE under two rectangular sampling box conditions. The SWS acquired under different conditions was compared. Variability was evaluated using the coefficient of variation (CV). The intraclass correlation coefficient (ICC) was used to evaluate repeatability.ResultsThe SWS of the tendons ex‐vivo, buried in the couplant and placed in the isolated muscles showed significant differences (p < 0.001). The ex‐vivo condition produced the highest SWS and CV values. There were significant differences in SWS of livers with different sizes placed in muscles (p < 0.001). The highest SWS value was associated with small pieces of livers. No significant difference was found in SWS acquired under different rectangular box sizes (p > 0.05).ConclusionsUnder the present study conditions, the surrounding environment of the target tissue makes a big difference to lesion SWS values. The lesion size will affect the assessment of its inherent elasticity. The size of the sampling frame has no significant effect on the tissue SWS.
Anti‐Dehydration and Rapid Trigger‐Detachable Multifunctional Hydrogels Promote Scarless Therapeutics of Deep Burn
Authors: An Heng , Zhang Meng , Zhou Liping , Huang Zhe , Duan Yongchao , Wang Cheng , Gu Zhen , Zhang Peixun , Wen Yongqiang 
Published: February 2023

AbstractThere are issues and challenges in treating deep burns because of the long recovery time, frequent dressing changes, wound infection, and easy to form scar that influence aesthetics. Besides, some specific tissues are not suitable for large dressing coverage (e.g., face, perineum). Therefore, an ideal deep burn dressing should have good adhesion properties to fit the wound effectively, painless and quick replacement, resistant to infection, accelerate wound healing, reduce scarring and facilitate monitoring and diagnosis. Herein, an anti‐dehydration and rapid‐trigger multifunctional hydrogel dressing is prepared by interface reaction. The Pacrylamide‐Formylboronicacid‐Tannic acid (PAFT) hydrogels are prepared by a simple method on anti‐dehydration elastomeric membrane, which is obtained using tannic acid as a dynamic cross‐linking agent with 3‐formylboronic acid and acrylamideunder UV light. The hydrogel exhibits a strong interfacial adhesion (892 J m−2 ± 65 J m−2), which rapidly (2 min) decreases (to 180 J m−2 ± 20 J m−2) when in the presence of glucose solution. The hydrogel has excellent anti‐dehydration and moisturizing properties, and also exhibits superior antibacterial properties, hemostasis, and biocompatibility. This hydrogel is transparent allowing effective observation of wound transformation and therapeutics. Moreover, PAFT hydrogel accelerates the healing of deep burns and reduces scars.
Ligand‐Binding Mediated Gradual Ionic Transport in Nanopores
Authors: Varol H. Samet , Förster Claire , Andrieu‐Brunsen Annette 
Published: February 2023

AbstractSelective binding of metal ions to their receptors at the cell membranes is essential for immune reactions, signaling, and opening/closing of the ion channels. Such ligand‐binding‐based pore activities inspire scientists to build metal‐ion‐responsive mesoporous films that can interact with metal ions to tune the ionic nanopore transport. However, to apply these mesoporous films in novel sensing and separation applications, their ligand‐binding‐triggered ionic pore transport needs to be understood fundamentally toward programming the transport of both anions and cations simultaneously and gradually. Herein, it is shown how Ca2+ ion concentration and attachment to the different chemistry silica nanopores tunes finely the nanopore transport of both anions and cations, especially for phosphate‐containing polyelectrolyte (PMEP) functionalized mesopores. This biased ligand binding can gradually regulate the transport of anions and cations, whereas pores without polymers can gradually regulate only the anionic transport. Last, pore polymer functionality related to Ca2+ ion binding also diverts the pores’ adsorption/desorption (reversibility) response. Almost fully reversible Ca2+ binding is observed in non‐functional pores and non‐reversible Ca2+ binding at the PMEP‐modified pores. It is also demonstrated that non/functional pores, even at sub‐µm concentrations, bind only divalent Ca2+ ions, but they are not selective to trivalent Al3+ ions.
Enhance the Properties of BiI3‐Based Resistive Switching Devices via Mixing Ag and Au Electrodes
Authors: Li Chia‐Shuo , Wu Yu‐Tien , Lin Po‐Feng , Chen Bo‐You , Fu Fang‐Yu , Cheng Ju‐Feng , Chang Yu‐Song , Ni I‐Chih , Hsu Yu‐Kuei , Pai Yi‐Hao , Chen Mei‐Hsin 
Published: February 2023

AbstractThe correlation between the electrodes and the properties of the BiI3 device is systematically investigated. The X‐ray and UV photoemission spectroscopies are carried out to study the chemical state and electronic structure of the metal/BiI3 interfaces formed by the in‐situ deposition of BiI3 on the metal. This revealed the upward diffusion of Ag and the self‐formation of a conductive filament; the latter is further confirmed via tunneling electron microscopy. By coating the Au substrate with Ag layers of various thicknesses as a buffer layer, the morphology, surface roughness, chemical states, and quantity of the filament in the BiI3 layer can be manipulated. The device with the structure of Au/10 nm Ag/BiI3/Au demonstrated an ultrahigh on/off ratio of 109, good retention of 104 s, and multistate data storage. This study provides not only a fundamental insight into the interaction of BiI3 with metal, which will be helpful to design resistive switching devices and optoelectronics based on BiI3 material, but also a facile method to control the quantity of conductive filament in the BiI3 layer.
Tumor Cell Derived Lnc‐FSD2‐31:1 Contributes to Cancer‐Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR‐4736
Authors: Geng Xinglong , Li Le , Luo Yan , Yang Wenbo , Hu Jisheng , Zhao Zhongjie , Cheng Chundong , Zhang Tao , Zhang Yangyang , Liu Liwei , Xie Yu , Li Guanqun , Liu Danxi , Bai Rui , Bai Xuewei , Wang Gang , Chen Hua , Wang Yongwei , Chen Hongze , Sun Bei 
Published: February 2023

AbstractPancreatic ductal adenocarcinoma (PDAC) presents with high mortality and short overall survival. Cancer‐associated fibroblasts (CAFs) act as refuge for cancer cells in PDAC. Mechanisms of intracelluar communication between CAFs and cancer cells need to be explored. Long noncoding RNAs (lncRNAs) are involved in the modulation of oncogenesis and tumor progression of PDAC; however, specific lncRNAs and their mechanism of action have not been clarified clearly in tumoral microenvironment. This work aims to identify novel lncRNAs involved in cellular interaction between cancer cells and CAFs in PDAC. To this end, differentially expressed lncRNAs between long‐term and short‐term survival PDAC patients are screened. Lnc‐FSD2‐31:1 is found to be significantly increased in long‐term survival patients. This work then discovers that tumor‐derived lnc‐FSD2‐31:1 restrains CAFs activation via miR‐4736 transported by extracellular vesicles (EVs) in vitro and in vivo. Mechanistically, EVs‐derived miR‐4736 suppresses autophagy and contributes to CAFs activation by targeting ATG7. Furthermore, blocking miR‐4736 suppresses tumor growth in genetically engineered KPC (LSL‐KrasG12D/+, LSL‐Trp53R172H/+, and Pdx‐1‐Cre) mouse model of PDAC. This study demonstrates that intratumoral lnc‐FSD2‐31:1 modulates autophagy in CAFs resulting in their activation through EVs‐derived miR‐4736. Targeting miR‐4736 may be a potential biomarker and therapeutic target for PDAC.