bluuebunny/crossref_metadata_2025_split huggingface dataset:
DosePatch: Physics-Inspired cropping layout for Patch-based Monte Carlo simulations to provide fast and accurate internal dosimetry
Authors: De Benetti Francesca , Brosch-Lenz Julia , González Jorge Mario Guerra , Uribe Carlos , Eiber Matthias , Navab Nassir , Wendler Thomas 
Published: June 2023

Abstract
Background: Dosimetry-based personalized therapy was shown to have clinical benefits e.g. in liver selective internal radiation therapy (SIRT). Yet, there is no consensus about its introduction into clinical practice, mainly as Monte Carlo simulations (gold standard for dosimetry) involve massive computation time. We addressed the problem of computation time and tested a patch-based approach for Monte Carlo simulations for internal dosimetry to improve parallelization. We introduce a physics-inspired cropping layout for patch-based MC dosimetry, and compare it to cropping layouts of the literature as well as dosimetry using organ-S-values, and dose kernels, taking whole-body Monte Carlo simulations as ground truth. This was evaluated in five patients receiving Yttrium-90 liver SIRT.
Results: The patch-based Monte Carlo approach yielded the closest results to the ground truth, making it a valid alternative to the conventional approach. Our physics-inspired cropping layout and mosaicking scheme yielded a voxel-wise error of ≈ 3% compared to whole-body Monte Carlo in soft tissue, while requiring only ≈ 10% of the time.
Conclusions: This work demonstrates the feasibility and accuracy of physics-inspired cropping layouts for patch-based Monte Carlo simulations.
The Effect of Nursing Educators’ Cultural Competence on Health Promotion in Society: A Systematic Review
Authors: Majnoon Sahand , Lotfi Mojgan 
Published: June 2023

Abstract
Introduction
Cultural care is an essential aspect of nursing as a holistic profession. Culture influences individuals’ health behaviours, so nurses should be attentive to cultural diversity. Health promotion and disease prevention are among the main goals of nursing and caring disciplines. Nursing educators play a vital role in transferring cultural care knowledge and skills that can enhance health promotion in society. This study aimed to review the literature on the impact of nursing educators’ cultural competence on social health.
Methods
This was a review study that searched library resources and the PubMed, Google Scholar, Scopus, and Web of Science (WOS) databases using the keywords cultural competence, nursing educators, culture, and health promotion. The search yielded 447 articles published from 1990 to 2023. Out of these, 21 articles that addressed culture, cultural competence, and health promotion were selected after an initial screening and evaluation.
Results
Due to the breadth and importance of the topic, the results were presented in seven sections, and the different dimensions of the topic were discussed according to the research questions. Specifically, the researchers explored culture and its impact on health and care in the first section, defined transcultural nursing in the second section, examined cultural competence and its definitions in the third section, investigated the significance of cultural competence among nursing educators in the fourth section, assessed the cultural competence status of nursing educators in Iran and the world in the fifth section, and analysed the concept of health promotion and the effect of nursing educators’ cultural competence in the sixth and seventh sections, respectively.
Conclusion
Culture-based care provision is crucial for promoting health in society. The cultural competence of nursing educators as the transmitters of this knowledge is highly important. Several studies on health promotion and disease prevention have highlighted this issue. The main findings of these studies have been summarized in this review.
Combined effect of artificial cervical disc replacement and facet tropism on the index-level facet joints: a finite element study
Authors: Rong Xin , Li Jing , Zhang Junqi , Wang Beiyu , Huang Kangkang , Liu Hao 
Published: June 2023

Abstract
Objective
The purpose of this study was to assess the impact of facet tropism on the facet contact force and facet capsule strain after artificial cervical disc replacement (ACDR).
Methods
A finite element model was constructed from computed tomography (CT) scans of a 28-year-old male volunteer. Symmetrical, moderate asymmetrical (7 degrees tropism), and severe asymmetrical (14 degrees tropism) models were created at the C5/C6 level. C5/C6 ACDR was simulated in all models. A 75 N follower load and 1 N⋅m moment was applied to the odontoid process to initiate flexion, extension, lateral bending, and axial rotation, and the range of motions, facet contact forces, and facet capsule strains were recorded.
Results
In the severe asymmetrical model, the right-side FCF increased considerably under extension, right bending, and left rotation compared with the symmetrical model after C5/C6 ACDR. The ride-side FCFs of the severe asymmetrical model under extension, right bending, and left rotation were about 1.7, 3.1, and 1.8 times of those of the symmetrical model, respectively. The facet capsule strains of both the moderate and severe asymmetrical models increased significantly compared with those of the symmetrical model after C5/C6 ACDR. The left-side capsule strains of the severe asymmetrical model were 2.1, 2.4, 1.6, and 8.5 times of those of the symmetrical model under left bending, right bending, left rotation, and right rotation, respectively. The right-side capsule strains of the severe asymmetrical model were 6.3, 1.6, 3.7, and 2.2 times of those of the symmetrical model under left bending, right bending, left rotation, and right rotation, respectively. The stress distribution on the facet surface in the asymmetrical models was different from that in the symmetrical model.
Conclusions
The existence of facet tropism could considerably increase facet contact force and facet capsule strain after ACDR, especially under extension, lateral bending, and rotation. Facet tropism also could result in abnormal stress distribution on the facet joint surface and facet joint capsule. Such abnormality might be a risk factor for post-operative facet joint degeneration progression after ACDR, making facet tropism noteworthy when ACDR was considered as the surgical option.
Allometric Scaling Inspection Through Figurate Numbers
Authors: Adiguzel Yekbun 
Published: June 2023

Abstract
Allometric scaling is a widely-studied, and discussed phenomena in biology that relates the parameters with a power function. There is still space for further investigation. Accordingly, the relationship is aimed to be explained for the first time in this work, through the figurate numbers, specifically the triangular, square, pentagonal, and hexagonal numbers. These mathematical series have not been considered in terms of a possible relation with allometric scaling, which is a mathematical relation in essence. We formulated the possible means of the relation of these figurate numbers with allometric scaling and suggested that their utilization can end up in different exponents and constant multipliers at varying scaling ranges. We also discussed further implications and exemplified the possible association with the blood flow-related metabolic rate adaptation. It is revealed that figurate numbers are having an inherent relation with the allometric scaling.
Intersectionality in transnational English teaching: Exploring the dynamics of privilege and disadvantage in Korean ELT
Authors: Kudaibergenov Meerbek 
Published: June 2023

Abstract

This article explores the niche occupied by transnational English teachers within the context of Korean ELT. Employing intersectionality theory as an analytic framework, the study examines the experiences of Leo (pseudonym), a German national who taught English in Korea circumventing legal restrictions against non-native English-speaking teachers. Through an analysis of Leo's narrative, this research elucidates the complex dynamics of privilege and disadvantage prevalent in the Korean ELT industry. The findings underscore the significance of nationality, race, and marital status in securing a teaching position, revealing a persistent preference for Caucasian teachers and the perpetuation of White supremacy in ELT. Leo's experiences shed light on broader issues of power imbalances, exploitation, and identity tensions that transnational teachers encounter. These findings contribute to a nuanced understanding of the niche occupied by transnational English teachers and provide insights for the development of inclusive and equitable policies and practices in foreign language education.
Impact assessment of relative effectiveness of Ascorbic acid, Salicylic acid and orange juice on soybean cultivar (Glycine Max. L.) under temperature acclimated UV radiation stress
Authors: Arsule Anuja Anil , Nigam Bhavna , Chaudhary Indra Jeet 
Published: June 2023

Abstract

Increasing composition of gaseous pollutant derived by anthropogenic activity disturbed natural atmospheric gaseous composition and deplete the stratospheric ozone layer. Major consequences of this depletion are increase incidents of harmful UV-B radiations reaching to terrestrial surface. Plants being permanent tool to removed harmful effect of solar radiation. Plants use sunlight as primary energy sources, therefore the small increase in UV-B radiation is recognized as harmful for plants. Many studies have shown that solar UV-B radiation causes significantly effect on morphological, physiological and yield components the plant. Therefore the present study conducted for assessment of relative effectiveness of Ascorbic acid, Salicylic acid and orange juice on soybean cultivar (Glycine Max. L.) under temperature acclimated UV radiation stress. Resultants ambient UV radiation caused harmful effect to soybean cultivar and reduce plant biomass 36% at juvenile stage and 40% at vegetative stage as compared to UV filter treatment. The effectiveness of Ascorbic acid, Salicylic acid and orange juice was following the trends 40%OJ > 20%OJ > 50ppm AA > 100ppm AA > 100ppm SA > 50ppm SA as compared to control plant. Based on obtained results orange juice and synthetic ascorbic acid will be useful tool for assessment of harmful effect of UV radiation on plants.
Exploration of the spiritual expectations of patients in a Swiss hemodialysis center
Authors: Mastrangelo Simon , Rochat Etienne , Pruijm Menno 
Published: June 2023

Abstract
Background
Previous American studies suggest that dialysis patients want caregivers to discuss spirituality and mobilize appropriate spiritual resources. Whether this also applies to the Swiss dialysis population, and whether patients' spiritual experiences contribute to their coping mechanisms is unknown. The goal of this pilot study is therefore to explore the spiritual expectations of hemodialysis patients in a Swiss dialysis center.
Methods
A qualitative study was conducted. Semi-structured interviews were performed by an experienced sociologist with dialysis patients in the ambulatory chronic dialysis unit of the University Hospital of Lausanne, Switzerland. The interviews included a set of pre-defined, open questions based on SPIR and HOPE, two validated tools to assess spirituality. The questions included three themes: the role that spirituality plays in patients’ life, in (coping with) their illness and in the recent COVID-19 epidemic. All interviews were recorded, transcribed, and then coded and analyzed following the approach of content analysis.
Results
Interviews took place between February and June 2022. The mean age of the 20 participants was 62.5 years (min 30-max 86), 40% were female. In total 14/20 (70%) patients practiced some form of religion (believers), 4 were agnostics, and 2 defined themselves as atheist. The majority of participants of this study (75%) consider that spirituality can play a positive role to preserve hope and to manage the difficulties caused by the disease and its treatment. The need for spiritual guidance is however not among the patients’ most urgent needs. Although some of them are open to the possibility of spiritual guidance within the hemodialysis unit, none of them expressed this as a formal expectation. Research participants’ level of spirituality and spiritual practice have generally not been significantly impacted by their changing health status, or the recent COVID-19 pandemic. The most frequently mentioned needs are related to social dimensions (isolation, loneliness, need to talk, financial problems).
Conclusions
In this pilot study, the majority of Swiss dialysis patients did not express the wish to discuss more often spiritual issues with dialysis caregivers, but they would appreciate more attention for social and socio-economic difficulties.
Machine Learning for Detecting Trends and Topics from Research Papers and Proceedings in Biomedical Literature
Authors: Dixon Jose , Rahman Md Mahmudur 
Published: June 2023

Abstract
The work presents robust statistical and exploratory analysis to demonstrate the effects of performances of machine learning (ML) classifiers and sampling techniques in document datasets. 1,000 portable document format (PDF) files are divided into five labels from the World Health Organization COVID-19 Research Downloadable Articles and PubMed Central databases for positive and negative papers. PDF files are converted into unstructured raw text files and pre-processed before tokenization. Training size and subsampling were varied experimentally to determine their effect on the performance measures, such as accuracy, precision, recall, and AUC. Supervised classification is performed using the Random Forest, Naïve Bayes, Decision Tree, XGBoost, and Logistic Regression. Imbalanced sampling techniques are implemented using the Synthetic Minority Oversampling Technique, Random Oversampling, Random Undersampling, TomekLinks, and NearMiss to address the problem of distribution of positive and negative samples. R and the tidyverse are used to conduct statistical and exploratory data analysis on performance metrics. The ML classifiers achieve an average precision score of 78% and a recall score of 77%, while the sampling techniques have higher average precision and recall scores of 80% and 81%, respectively. Correcting imbalanced sampling supplied significant p-values from NearMiss, ROS, and SMOTE for precision and recall scores. This work has shown with statistical significance including the analysis of variance (ANOVA) that training size variation, subsampling, and imbalanced sampling techniques with ML algorithms can improve performances in document datasets.
Influence of parameters on performance characteristics and defects during laser micro drilling of titanium alloys using RSM
Authors: Chatterjee Suman , Mahapatra Siba Sankar , Xu Jinyang , Brabazon Dermot 
Published: June 2023

Abstract
Titanium (Ti) and its alloys have received significant attention in recent years, particularly for applications in the medical science, automobile, and aerospace sectors. Drilling is used for around 40 percent to 60 percent of an aeronautical product's material removal processes. Non-conventional machining can be considered to obtain an optimal quality of drilled holes. The present study has employed a pulsed Nd:YAG laser having 250 W average power to perform the micro-drilling on titanium alloy of 0.45 mm thick sheet. The study focuses on determining the impact of laser parameters (gas pressure (4 ~ 8 bar), laser input current (200 ~ 260 A), pulse width (4 ~ 8 ms), and pulse repetition rate (1 ~ 7 Hz)) on performance characteristics during micro drilling on a thin foil of titanium alloy having 0.45 mm thickness. To evaluate the quality of micro-drilled holes, aspects, e.g., circularity, spatter area, and taper, have been considered. The response surface methodology based on the design of experiment technique was employed to estimate the influence of parameters on performance characteristics with the least number of experiments. The study indicates that assistant gas pressure, pulse width, and laser input current are the essential parameters in taper formation and spatter deposition. The study suggests that the increase in pulse repetition rate and pulse width improves the circularity of the hole. The electron micrography of the drilled holes helps to determine the development of the heat-affected zone (HAZ) and micro-crack near drilled holes. The presented research provides a new understanding of how the process parameters contribute to HAZ development, crack occurrence and intensity.
Robust acceleration of Earth system heating observed over the past six decades
Authors: Minière Audrey , von Schuckmann Karina , Sallée Jean-Baptiste 
Published: June 2023

Abstract
Global heating of the Earth system is unequivocal. However, detecting an acceleration of Earth heating has remained elusive to date, despite suggestive evidence of a potential increase in heating rates. In this study, we demonstrate that since 1960, the warming of the world ocean has accelerated at a relatively consistent pace of 0.15±0.02 W/m2/decade, while the land, cryosphere, and atmosphere have exhibited an acceleration pace of 0.013±0.002 W/m2/decade. This has led to a substantial increase in ocean warming, with a magnitude of 0.82±0.47 W/m2 between the decades 1960-1970 and 2010-2020, which overlays significant decadal-scale variability in ocean warming of up to 0.6 W/m2. Our findings withstand a wide range of sensitivity analyses and are consistent across different observation-based datasets. The long-term acceleration of Earth warming aligns qualitatively with the rise in CO2 concentrations and the decline in aerosol concentration during the same period, but further investigations are necessary to properly attribute these changes.
"What is work?”: Perspectives of low-income young adults who use psychoactive substances and participate in a harm reduction-based low-threshold work program
Authors: Guilhon Ana Cecilia Villela , Bertrand Karine , Wagner Vincent , Haig Thomas , Goyette Martin 
Published: June 2023

Abstract
Background. Young adults in situations of social precarity are more exposed to the risks associated with both unemployment and psychoactive substance use. Low-threshold work is a promising alternative for this cohort, yet it has been little studied to date. This qualitative study describes the significance of both work in general and low-threshold work for these individuals.
Methods. Semi-structured interviews were conducted with 23 young adults who had participated in a low-threshold work program. The interviews were transcribed and subsequently analyzed thematically, filtered through a life course theory perspective.
Results. Participants defined “work” as remunerated activity carried out within a formalized framework. The meanings they ascribed to work were somewhat negative, marked by prior experiences of abuse and exploitation. Precarious living conditions were also difficult to reconcile with the routines of full-time employment. However, a different set of meanings was ascribed to low-threshold work. Beyond representing temporary economic relief, it was experienced positively on a number of fronts and categorized by participants as distinctive from what they called “real work.”
Conclusion. Low-threshold work as a harm reduction-based intervention strategy presents a number of potential benefits that include the chance to form lasting relationships, gain exposure to enjoyable work, and be supported in a process of change liable to promote the achievement of certain goals. A broadened definition of work that extends beyond the notion of productivity, as is programs like TAPAJ, could thus provide young people in situations of social precarity with more rewarding income-generating opportunities in addition to fostering feelings of achievement.
Molecular and clinicopathological characteristics of EGFR gene fusions in 35,023 Chinese patients with solid tumors
Authors: Zhang Haiping , Wang Wuping , Li Xiaoxiao , Zhang Dongfeng , Qi Yingxue , He Qianru , Zhang Qin , Luo Ningning , Sun Tingting , Qi Chuang , Wang Xiaoou , Wang Tuo 
Published: June 2023

Abstract
Epidermal growth factor receptor (EGFR) fusions are rare but potentially actionable oncogenic drivers across multiple solid tumors. Here, we assessed the incidence of EGFR fusions and described their impact on prognosis in solid tumors. Panel-based next-generation sequencing (NGS) data of 35,023 patients with different types of solid tumors were collected and analyzed from the Simcere Diagnostics (Nanjing, China) database. A 9563-patient cohort was derived from The Cancer Genome Atlas (TCGA) to explore the relationship between EGFR fusion status and overall survival (OS). In our cohort, 0.303% (106/35016) of patients harbored EGFR fusions. The frequencies of EGFR fusions were different in diverse tumor types, ranging from 0.034–1.613%. Gastroesophageal junction cancer had the highest frequency of fusion (1.613%), followed by medatloblastoma (1.515%) and glioma (1.370%). The fusion partner gene is also different in various cancer types. The top 3 genes that comutated with EGFR fusion were TP53 (mutation frequency, MF: 65%), BRCA2 (MF: 43%), and ALK (MF: 41%). In the TCGA cohort, patients in the EGFR fusion group had a significantly shorter OS than those in the non-EGFR fusion group (p < 0.0001), suggesting that EGFR fusion might be a high-risk factor for poor prognosis. Our study is the first retrospective analysis of EGFR fusions in a large-scale solid tumor population, which may provide a reference for future EGFR-TKI clinical trials with EGFR fusions.
Posaconazole and risk of cutaneous squamous cell carcinoma after lung transplantation: a single institution, retrospective cohort study
Authors: Kuklinski Lawrence F. , Klomhaus Alexandra M. , Shen Amy , Achamallah Natalie , Soriano Teresa T. , Saggar Rajan , Weigt Stephen S. 
Published: June 2023

Abstract
The antifungal voriconazole is often used to reduce the risk of invasive fungal infection after lung transplantation but is associated with an increased risk of cutaneous squamous cell carcinoma (SCC) in this population. The risk of post-transplant SCC related to posaconazole remains incompletely understood. To evaluate the post-transplant risk of SCC related to posaconazole, we created cohorts of lung transplant recipients were created post-transplant antifungal protocol including universal posaconazole prophylaxis (UAP-P), universal voriconazole prophylaxis (UAP-V), and targeted prophylaxis (TAP) with overall low antifungal use. Cumulative incidence of SCC in the UAP-V cohort was higher than either the TAP or UAP-P cohorts but did not differ between the UAP-P and TAP cohorts. In multivariate analysis, the hazard ratio for SCC was not statistically significantly different between the UAP-P and TAP cohorts (hazard ratio = 0.86, p = 0.6294), but was twice as high for the UAP-V cohort compared to the TAP cohort (hazard ratio = 2.06, p = 0.0111). Posaconazole does not appear to be associated with increased risk of SCC after lung transplantation.