bluuebunny/crossref_metadata_2025_split huggingface dataset:
Report of the 23rd nationwide follow‐up survey of primary liver cancer in Japan (2014–2015)
Authors: Iijima Hiroko , Kudo Masatoshi , Kubo Shoji , Kurosaki Masayuki , Sakamoto Michiie , Shiina Shuichiro , Tateishi Ryosuke , Osamu Nakashima , Fukumoto Takumi , Matsuyama Yutaka , Murakami Takamichi , Takahashi Arata , Miyata Hiroaki , Kokudo Norihiro 
Published: August 2023

AbstractFor the 23rd Nationwide Follow‐up Survey of Primary Liver Cancer in Japan, data from 20 889 newly registered patients and 42 274 previously registered follow‐up patients were compiled from 516 institutions over a 2‐year period from January 1, 2014 to December 31, 2015. Basic statistics compiled for patients newly registered in the 23rd survey were cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment‐related factors, pathological diagnosis, recurrence status, and autopsy findings. Compared with the previous 22nd survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, had more patients with non‐B non‐C HCC, had smaller tumor diameter, and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma, and combined hepatocellular cholangiocarcinoma (combined HCC and intrahepatic cholangiocarcinoma) by treatment type and background characteristics for patients newly registered between 2004 and 2015 whose final outcome was survival or death. The median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter, Child–Pugh grade, or albumin‐bilirubin grade) and by treatment type (hepatectomy, radiofrequency ablation therapy, transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy, and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2015 into five time period groups. The data obtained from this nationwide follow‐up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer in the world.
Comparison of the performance of two automatic cell morphology analyzers for peripheral‐blood leukocyte morphology analysis: Mindray MC‐100i and Sysmex DI‐60
Authors: Zhang Shihong , He Yongjian , Wu Wenjing , Tan Hongxia , Xie Shuhua , Liu Min , Chen Wei , Sun Dehua 
Published: August 2023

AbstractIntroductionTo compare the morphological classification ability of peripheral‐blood leukocytes of the automatic cell morphology analyzers MC‐100i and DI‐60.Methods(1) MC‐100i and DI‐60 were used to analyze leukocytes in 432 venous blood samples collected from three tertiary hospitals across China. The preclassification results were compared with the results reported by senior morphological experts (postclassification results) to evaluate the accuracy, sensitivity, specificity, and consistency of leukocyte preclassification for both instruments. (2) In 200 of the 432 blood samples, morphological experts conducted manual microscopic examination for various types of leukocytes. The correlation between the MC‐100i and DI‐60 leukocyte postclassification results and the expert microscopist results were analyzed.Results(1) MC‐100i preclassified leukocytes and nucleated red blood cells (RBCs). Compared with the postclassification results, the total leukocyte preclassification accuracy of MC‐100i was 97.16%, while that of DI‐60 was 87.24%. The sensitivity of MC‐100i to abnormal cells (including blasts, promyelocytes, neutrophilic myelocytes, neutrophilic metamyelocytes, reactive lymphocytes, abnormal promyelocytes, plasma cells, abnormal lymphocytes and nucleated RBCs) was 90.24%, which was significantly higher than the 50.72% sensitivity of DI‐60. (2) Comparing the postclassification results with manual microscopy, except for reactive lymphocytes and basophils, the MC‐100i and DI‐60 results had good correlations with various leukocyte types and nucleated RBCs (r > 0.85), and MC‐100i was better than DI‐60 in the recognition of basophils.ConclusionBoth MC‐100i and DI‐60 have good detection ability for five normal types of leukocytes in peripheral blood. MC‐100i has significantly better detection sensitivity for abnormal cells in peripheral blood than DI‐60.
Validation of the culturally adapted Edinburgh postpartum depression scale among east Asian, southeast Asian and south Asian populations: A scoping review
Authors: Salehi Ashkan , Zhang Melody , Kithulegoda Natasha , Vigod Simone , Ivers Noah 
Published: August 2023

AbstractThe Edinburgh Postnatal Depression Scale (EPDS) is a widely used self‐report instrument to screen for postpartum depression (PPD). Assessing the relevance of the EPDS as a screening tool for minority ethnic populations is pertinent for ensuring culturally appropriate care. This scoping review aimed to explore what is known about the cultural adaptations of the EPDS in antepartum and postpartum mothers and fathers in East Asian, Southeast Asian and South Asian populations, and to what extent these adaptations are able to accurately screen for postpartum depression symptoms among these cultural groups. The scoping review was guided by the PRISMA‐ScR checklist. The search strategy included databases of MEDLINE, PsycINFO, EMBASE, CINAHL and Grey literature. Included studies were primary articles published in English language peer‐reviewed journals that investigated the validation or cultural adaptation of the EPDS in mothers who were pregnant and/or had recently given birth, or fathers who were new parents, and were limited to the following cultural groups, whether living locally or abroad in a foreign country: East Asian, Southeast Asian or South Asian populations. Thirty‐six of 2469 studies met criteria for inclusion. Twenty‐one of 36 studies utilizing a culturally validated EPDS demonstrated a cut‐off score lower than the original recommended cut‐off. Important themes identified included the Role of Culture, Somatization of PPD, Method of Interview, and contrasting performance compared to other scales used to assess depression and/or anxiety. Accessibility to translated and validated EPDS and mindfulness of ethnically relevant EPDS cut‐off scores are critical when using this tool among minority ethnic populations.
Climate risks and forecastability of the weekly state‐level economic conditions of the United States
Authors: Cepni Oguzhan , Gupta Rangan , Liao Wenting , Ma Jun 
Published: August 2023

AbstractIn this paper, we first utilize a dynamic factor model with stochastic volatility (DFM‐SV) to filter out the national factor from the local components of weekly state‐level economic conditions indexes of the United States (US) over the period of April 1987 to August 2021. In the second step, we forecast the state‐level factors in a panel data set‐up based on the information content of corresponding state‐level climate risks, as proxied by changes in temperature and its SV. The forecasting experiment depicts statistically significant evidence of out‐of‐sample predictability over a one‐month‐ to one‐year‐ahead horizon, with stronger forecasting gains derived for states that do not believe that climate change is happening and are Republican. We also find evidence of national climate risks in accurately forecasting the national factor of economic conditions. Our analyses have important policy implications from a regional perspective.
The impact of stockout‐based switching on fill rates
Authors: Pritchard Alan M. , Sweeney Kevin D. , Çelebi Heidi , Evers Philip T. 
Published: August 2023

AbstractThe possibility of product substitution due to a stockout provides retailers with a buffer against lost sales but can also complicate the management of inventory because both substitute and primary demand affect inventory levels. Since most retailers make their inventory decisions around a desired service level (e.g., fill rate), it is important to understand how customer substitution behavior can influence different measures of customer service. In this study, an extensive theoretical framework is presented and used to develop a decision tree approach for predicting realized item and category fill rates. We find that item fill rate is primarily a function of the target service level of the focal item and the willingness to switch from an alternate item to the focal item. Category fill rate is influenced by the target service level of both items, with willingness to switch amplifying their effect. The decision tree approach is found to be an accurate predictor in most cases, however, it tends to overestimate item fill rate when the willingness to substitute from the alternate item increases. The approach also accurately predicts category fill rates, outside of scenarios with asymmetric substitutability.
Value of genotyping and scar‐phenotyping for VT ablation procedures in patients with nonischemic left ventricular cardiomyopathies
Authors: Kovacs Boldizsar , Ghannam Michael , Liang Jackson , Moccoro Emmeline , Attili Anil , Cochet Hubert , Helms Adam , Latchamsetty Rakesh , Jongnarangsin Krit , Morady Fred , Bogun Frank 
Published: August 2023

AbstractIntroductionVariants of cardiomyopathy genes in patients with nonischemic cardiomyopathy (NICM) generate various phenotypes of cardiac scar and delayed enhancement cardiac magnetic resonance (DE‐CMR) imaging which may impact ventricular tachycardia (VT) management.MethodsThe objective was to compare the findings of cardiomyopathy genetic testing on DE‐CMR imaging and long‐term outcomes among patients with NICM undergoing VT ablation procedures. Image phenotyping and genotyping were performed in a consecutive series of patients referred for VT ablation and correlated to survival free of VT. Scar depth index (SDI) (% of scar at 0‐3 mm, 3‐5 mm and >5 mm projected on the closest endocardial surface) was determined.ResultsForty‐three patients were included (11 women, 55 ± 14 years, ejection fraction (EF) 45 ± 16%) and were followed for 3.4 ± 2.9 years. Pathogenic variants (PV) were identified in 16 patients (37%) in the following genes: LMNA (n = 5), TTN (n = 5), DSP (n = 2), AMLS1 (n = 1), MYBPC3 (n = 1), PLN (n = 1), and SCN5A (n = 1). A ring‐like septal scar (RLSS) pattern was more often seen in patients with pathogenic variants (66% vs 15%, p = .001). RLSS was associated with deeper seated scars (SDI >5 mm 30.6 ± 22.6% vs 12.4 ± 16.2%, p = .005), and increased VT recurrence (HR 5.7 95% CI[1.8‐18.4], p = .003). After adjustment for age, sex, EF, and total scar burden, the presence of a PV remained independently associated with worse outcomes (HR 4.7 95% CI[1.22‐18.0], p = .02).ConclusionsPreprocedural genotyping and scar phenotyping is beneficial to identify patients with a favorable procedural outcome. Some PVs are associated with an intramural, deeper seated scar phenotype and have an increase of VT recurrence after ablation.
The initial number of fetuses in multiple pregnancy before reduction affects perinatal outcomes
Authors: Akkuş Fatih , Doğru Şükran , Atcı Aslı Altınordu , Dal Yusuf , Arıcı Elifsena Canan Alp , Acar Ali 
Published: August 2023

AbstractObjectiveIn this study, we aimed to evaluate the perinatal outcomes of dichorionic diamniotic (DCDA) twin pregnancies reduced by the fetal reduction (FR) procedure and cases with continuing DCDA twin pregnancies without FR.Materials and MethodsFR performed in a university hospital in the last 10 years was evaluated. Pregnancies reduced to DCDA twin pregnancies by reduction from three or more pregnancies and pregnancies that started with DCDA twins and continued with DCDA twins were compared in terms of perinatal outcomes. In the subgroup analysis, those who were reduced from three‐chorionic three‐amniotic (TCTA) triplets to DCDA twins and those who were reduced to DCDA twin pregnancies from four or more were compared in terms of perinatal outcomes.ResultsA total of 119 pregnant women were included in the study, 36 patients underwent FR, while 83 patients were DCDA twins who did not undergo FR. The groups were similar in terms of preterm delivery (p = 0.370). There was a higher rate of miscarriage (21.4% vs. 0.0%, p = 0.019) in the group that was reduced to DCDA twins from quadruplet and above pregnancies compared to the group that was reduced from TCTA triplets to DCDA twins. The gestational week at birth was lower in the group reduced to DCDA twins from quadruplets and above pregnancies (31.00 ± 4.31 vs. 34.64 ± 2.88, p = 0.019).ConclusionThe study's results show that the perinatal outcomes of multiple pregnancies with and without FR are the same As the number of reduced fetuses increases, the rates of preterm birth and miscarriage also increase.
There is a party in my head and no one is invited: Resting‐state electrocortical activity and solitude
Authors: Huang Chengli , Butterworth James W. , Finley Anna J. , Angus Douglas J. , Sedikides Constantine , Kelley Nicholas J. 
Published: August 2023

AbstractObjectiveWhat are the motivational underpinnings of solitude? We know from self‐report studies that increases in solitude are associated with drops in approach motivation and rises in avoidance motivation, but only when solitude is experienced as non‐self‐determined (i.e., non‐autonomous). However, the extent to which individual differences in solitude relate to neurophysiological markers of approach–avoidance motivation derived from resting‐state electroencephalogram (EEG) is unknown. These markers are Frontal Alpha Asymmetry, beta suppression, and midline Posterior versus Frontal EEG Theta Activity.MethodWe assessed the relation among individual differences in the reasons for solitude (i.e., preference for solitude, motivation for solitude), approach–avoidance motivation, and resting‐state EEG markers of approach–avoidance motivation (N = 115).ResultsGeneral preference for solitude was negatively related to approach motivation, observed in both self‐reported measures and EEG markers of approach motivation. Self‐determined solitude was positively related to both self‐reported approach motivation and avoidance motivation in the social domain (i.e., friendship). Non‐self‐determined solitude was positively associated with self‐reported avoidance motivation.ConclusionThis research was a preliminary attempt to address the neurophysiological underpinnings of solitude in the context of motivation.
Characterization of sugarcane mosaic virus from Cymbopogon spp. plants in Brazil
Authors: Bello Vinicius Henrique , Carpim Larissa , Kitajima Elliot Watanabe , Rezende Jorge Alberto Marques 
Published: August 2023

AbstractIn April 2022, virus‐like symptoms were observed in a Cymbopogon spp. plant grown in the backyard of a house and in Java citronella (C. winterianus) plants in a flower shop in Piracicaba, São Paulo State, Brazil. In April 2023, ca. 700,000 Ceylon citronella (C. nardus) plants showing symptoms of mosaic were observed in a field crop in Dois Corrégos (SP). Evidence for a possible potyvirus infection was revealed by electron microscopy and confirmed by molecular assays. Nucleotide sequencing of amplicons from RT‐PCR identified the potyvirus infecting a Cymbopogon spp. plant, Java and Ceylon citronella as sugarcane mosaic virus (SCMV, genus Potyvirus). Phylogenetic analysis of the coat protein gene indicated that the SCMV isolates from Cymbopogon (C1), Java (JC1), and Ceylon citronella (CC) belong to the clade of SCMV from sugarcane. The C1 isolate, and an isolate from sugarcane (SCMV‐SU) (control) were mechanically transmitted to Java citronella, sorghum, sugarcane and maize plants. Aphis gossypii transmitted the C1 and SU isolates to Java citronella plants, while Melanaphis sacchari transmitted only the SU isolate to Java citronella plants. This is the first molecular characterization of SCMV from Cymbopogon spp. plants.
Gastric electrical stimulation is safe during pregnancy and delivery: Results from a French cohort
Authors: Soliman Heithem , Schalla Martha A. , Coffin Benoît , Gourcerol Guillaume 
Published: August 2023

AbstractBackgroundGastric electrical stimulation (GES) is an effective therapy in medically refractory chronic nausea and vomiting. GES is assumed to be a contraindication for pregnancy. We examined the safety of GES during pregnancy and its clinical impact on vomiting symptoms.MethodsA retrospective study was performed in two tertiary centers including all female patients of childbearing age implanted with GES. Patients without pregnancy while on GES were asked about their desire and concerns about pregnancy. Patients who were pregnant while on GES therapy were interviewed about the course of the pregnancy and labor, as well as the health of the children.Key ResultsAmong 91 patients implanted at childbearing age, 54 patients without pregnancy answered the questionnaire. Nine patients (16.7%) reported a desire for pregnancy and five patients (7.4%) reported worries about the safety of GES during pregnancy. Sixteen pregnancies were reported in 10 patients. All pregnancies ended in a live birth with premature birth in 12 pregnancies (75.0%). No health concern was currently noted in these children. No severe GES‐related complications occurred during pregnancy with only pain at the implantation site reported during 3 pregnancies (18.8%). The severity and frequency of nausea and vomiting significantly increased during the first trimester (p = 0.04 and p = 0.005, respectively) and decreased after the delivery, becoming lower than before the pregnancy (p = 0.044 and p = 0.011, respectively).Conclusion & InferencesPatients are concerned regarding pregnancy while being treated with GES. No serious maternal or fetal complications related to GES were noted in our cohort.
Calmodulin and calmodulin‐like protein‐mediated plant responses to biotic stresses
Authors: Zeng Houqing , Zhu Qiuqing , Yuan Peiguo , Yan Yan , Yi Keke , Du Liqun 
Published: August 2023

AbstractPlants have evolved a set of finely regulated mechanisms to respond to various biotic stresses. Transient changes in intracellular calcium (Ca2+) concentration have been well documented to act as cellular signals in coupling environmental stimuli to appropriate physiological responses with astonishing accuracy and specificity in plants. Calmodulins (CaMs) and calmodulin‐like proteins (CMLs) are extensively characterized as important classes of Ca2+ sensors. The spatial‐temporal coordination between Ca2+ transients, CaMs/CMLs and their target proteins is critical for plant responses to environmental stresses. Ca2+‐loaded CaMs/CMLs interact with and regulate a broad spectrum of target proteins, such as ion transporters (including channels, pumps, and antiporters), transcription factors, protein kinases, protein phosphatases, metabolic enzymes and proteins with unknown biological functions. This review focuses on mechanisms underlying how CaMs/CMLs are involved in the regulation of plant responses to diverse biotic stresses including pathogen infections and herbivore attacks. Recent discoveries of crucial functions of CaMs/CMLs and their target proteins in biotic stress resistance revealed through physiological, molecular, biochemical, and genetic analyses have been described, and intriguing insights into the CaM/CML‐mediated regulatory network are proposed. Perspectives for future directions in understanding CaM/CML‐mediated signalling pathways in plant responses to biotic stresses are discussed. The application of accumulated knowledge of CaM/CML‐mediated signalling in biotic stress responses into crop cultivation would improve crop resistance to various biotic stresses and safeguard our food production in the future.
Expanding the clinical and immunological phenotype of prolidase deficiency: A case report
Authors: Basu Suprit , Barman Prabal , Das Jhumki , Kabeerdoss Jayakanthan , Attri Savita Verma , Mahajan Rahul , Vignesh Pandiarajan , Rawat Amit 
Published: August 2023

AbstractProlidase deficiency (PD) is a rare autosomal recessive disorder associated with recurrent infections, immune dysregulation, and autoimmunity. PD is characterized by persistent dermatitis, skin fragility, and non‐healing ulcerations on the lower limbs as its main dermatologic characteristics. Herein, we report a boy with PD due to a novel variant in PEPD who had abnormal facies, cognitive impairment, corneal opacity, recurrent infections, and persistent non‐healing leg ulcers. Th17 lymphocyte counts and phosphorylated‐STAT5 expression following IL‐2 stimulation were reduced in our patient as compared to healthy control.
Neural dynamics of vicarious physical pain processing reflect impaired empathy toward sexually objectified versus non‐sexually objectified women
Authors: Cogoni Carlotta , Monachesi Bianca , Mazza Veronica , Grecucci Alessandro , Vaes Jeroen 
Published: August 2023

AbstractSexually objectified women are perceived as dehumanized. This may affect the behavioral and neural responses underlying the observer's empathic reactions for their physical pain, although this hypothesis still lacks empirical support. In the present study, we measured the electrophysiological activity of 30 participants (14 females and 16 males), in an empathy for physical pain paradigm in which pictures of sexualized and non‐sexualized women were presented in painful and non‐painful situations. The behavioral results revealed that sexualized women were evaluated as experiencing less pain than non‐sexualized women. Neural evidence corroborated this finding showing that the perception of vicarious physical pain is lacking for sexualized women in both event‐related potentials (ERPs) and brain oscillation domains. Specifically, the P2 component and the event‐related synchronization/desynchronization (ERS/ERD) on the mu frequency band differed between painful and non‐painful stimulation exclusively when women were not sexualized. Our results provide the first evidence that the neurophysiological responses to the vicarious experience of physical pain are dampened or even absent for sexualized women. These findings expand our understanding of the neurophysiological signatures of empathic processes and highlight the detrimental effect of a sexual‐objectification bias in everyday contexts.
Examination of real‐time variation in interpersonal hopelessness and suicidal desire in a college student sample reporting past‐2‐week suicidal ideation
Authors: Gerner Jessica L. , Moscardini Emma H. , Mitchell Sean M. , Hill Ryan M. , Tucker Raymond P. 
Published: August 2023

AbstractIntroductionInterpersonal hopelessness (IH), as outlined in the Interpersonal Theory of Suicide, is theorized to include two correlated, distinct constructs: hopelessness about one's thwarted belongingness (IH‐TB) and about perceived burdensomeness on others (IH‐PB). Few studies have explored IH, and none have explored its temporal stability or prospective prediction of suicidal desire.MethodsUndergraduates (N = 43) selectively recruited for past‐2‐week suicidal ideation completed five ecological momentary assessment surveys per day for 10‐days. Intraclass correlations, root mean square of successive differences, and multilevel models were used to examine the data and test relationships among predictor variables.ResultsIH‐TB and IH‐PB demonstrated greater temporal stability than general hopelessness. IH‐TB, IH‐PB, and their interaction were significant predictors of suicidal desire concurrently and prospectively. IH‐PB was no longer significantly predictive of suicidal desire when adjusting for general hopelessness. Post‐hoc models showed that suicidal desire was not predictive of IH‐TB, IH‐PB, or their interaction suggesting the relationship is not recursive.ConclusionResults showed that interventions aimed at decreasing one's hopelessness specific to TB and PB may be beneficial for decreasing suicidal desire. Future research should seek to replicate these results in larger and more diverse samples and consider the use of shorter ambulatory assessment intervals.