bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIV in pregnant women group in the Republic of Guinea: frequency and genetic characteristics
Authors: Balde T.A.L. , Shchemelev A. N. , Ostankova Yu. V. , Boumbaly S. , Valutite D. E. , Davydenko V. S. , Serikova E. N. , Zueva E. B. , Anufrieva E. V. , Skvoroda V. V. , Vasileva D. A. , Esaulenko E. V. , Semenov A. V. , Totolian Areg A. 
Published: July 2023

The aim of this study was to assess the prevalence and study of the molecular genetic characteristics of the human immunodeficiency virus in pregnant women of the Republic of Guinea.Materials and methods. The material for the study was blood plasma samples of 972 pregnant women from the Republic of Guinea. The patients were examined for the presence of HIV infection serological (Ag+Ab) and molecular markers (RNA). For patients with a positive PCR result and a sufficient viral load (>500 c/ml), the genetic sequences of the pol gene fragment responsible for the synthesis of pro and rev proteins were obtained by Sanger sequencing. These sequences were used for phylogenetic analysis and examined for drug resistance mutations.Results and discussion. 12.96% of patients was positive in ELISA. Among women who were positive in ELISA, RNA was detected in 76.98% of cases, however, in 11 cases, RNA was detected in patients without serological markers of HIV infection, so the incidence of HIV RNA in the entire surveyed population was 11.11%. In the vast majority of cases, the circulating recombinant form 02_AG is found. Based on the analysis, we assume a significant contribution of recombinant forms of HIV to the genetic diversity of the virus in the region under study.The incidence of DR mutations was quite high (26.80%). The most frequent substitutions were in position 20 of the protease (70.10%, 95% CI 59.96–78.98%), of which the K20I mutation was dominant. In addition, the L10I/V mutation was relatively common, increasing the replication of viruses with other PI resistance mutations. Among the mutations associated with HIV resistance to NNRTIs, a non-polymorphic mutation V179T was found.Conclusion. An important factor influencing the effectiveness of Prevention of Mother to Child Transmission identified in this study was the high prevalence of PDR among pregnant women in Guinea. The high prevalence of drug resistance mutations found in this study in pregnant women, as well as in ART-naive women, indicates that current regimens in Guinea are insufficient to prevent vertical HIV infection.
MENINGKATKAN HASIL BELAJAR SISWA MELALUI METODE DISKUSI PADA MATA PELAJARAN IPS DI KELAS VIII-1 SMP NEGERI 4 MEDAN
Authors: SIREGAR JURIAH 
Published: July 2023

Penelitian ini bertujuan untuk melihat aktivitas dan prestasi belajar siswa saat bekerja dalam kelompok dikelas pada mata pelajaran IPS Terpadu dengan metode diskusi di kelas VIII-1 SMP N 4 Medan. Awal KBM dilakukan tes hasil belajar (Pretes), dengan data rata-rata 23,6 hal tersebut menunjukkan bahwa rata-rata siswa jarang membaca buku sebelum pembelajaran disekolah. Kemudian dilanjutkan KBM, akhir KBM ke II dan KBM ke IV dilakukan tes hasil belajar Postes I dan Postes II hasilnya masing-masing menunjukkan 72,8 dan 85,0. Melihat data tersebut ada perubahan dan perubahan tersebut akibat tindakan guru selama KBM pada Siklus II. Walaupun hasil belajar siswa tuntas tapi data tersebut tuntas minimum ini akibat siswa belum terbiasa belajar saling membantu. Selama KBM siswa kelihatan lebih tertarik terhadap mata pelajaran dan keingintahuannya sedikit lebih tinggi yang mengindikasikan bahwa ketertarikan siswa terhadap pelajaran karena keingintahuannya. Ini merupakan efek dari metode diskusi yang cukup menumbuhkan sikap ingin tahu dan minat terhadap pelajaran. Kata kunci : Metode Diskusi, Hasil Belajar
PENGELOLAAN MODEL PEMBELAJARAN TGT DALAM MENINGKATKAN MOTIVASI BELAJAR IPS KELAS VII-5 SMP NEGERI 3 PERCUT SEI TUAN
Authors: Br. Ginting Idawati 
Published: July 2023

Abstract: Management of Cooperative Learning Model to Improve Learning Motivation TGT IPS In Class VII-5 SMP Negeri 3 Percut Sei Tuan. This study aims to determine how the implementation of cooperative learning model TGT type in improving student motivation .. The research process was conducted in two cycles each of 4 meetings. The results showed an increase in students' motivation high motivation of 16.67% with a mean achievement 43.99% of indicators of motivation to learn in the initial observation, increasing became 33.33% with the average achievement of 46.40% at mid-cycle I and became 61.11% with the average achievement of 69.62% at the end I. in the mid-cycle second cycle students who are highly motivated rose to 80.56% with the average achievement of 75.09%, and at the end of the cycle II reached 91.67% with a mean of 80.99% achievement of indicators of students' motivation. Keywords : Motivation, Learning Methods Abstrak : Pengelolaan Model Pembelajaran Kooperatif Tipe TGT Dalam Meningkatkan Motivasi Belajar IPS Di Kelas VII-5 SMP Negeri 3 Percut Sei Tuan. Penelitian ini bertujuan untuk mengetahui cara penerapan model pembelajaran Kooperatif Tipe TGT dalam meningkatkan motivasi belajar siswa.. Proses penelitian ini dilaksanakan dalam dua siklus masing-masing 4 kali pertemuan. Hasil penelitian menunjukkan peningkatan motivasi belajar siswa yang bermotivasi tinggi dari 16.67% dengan rerata capaian 43.99% dari indikator motivasi belajar pada observasi awal, meningkatan menjadi 33.33% dengan rerata capaian 46.40% pada pertengahan siklus I dan menjadi 61.11% dengan rerata capaian 69.62% pada akhir siklus I. Pada pertengahan siklus II siswa yang bermotivasi tinggi naik mencapai 80.56% dengan rerata capaian 75.09%, dan di akhir siklus II mencapai 91,67% dengan rerata capaian 80.99% dari indikator motivasi belajar siswa. Kata Kunci : Motivasi Belajar, Metode Pembelajaran
PENERAPAN PERMAINAN TRADISIONAL ENGKLEK DALAM MENINGKATKAN KEMAMPUAN KOGNITIF ANAK USIA 5-6 TAHUN DI TK BINA GUNA
Authors: Desvarosa Eliya 
Published: July 2023

Abstract: Application Of Hopscotch Traditional Games Improve Cognitive Ability In Children Aged 5-6 Years In Kindergarten Bina Guna. The aim of research to determine the increase cognitive abilities of children through play hopscotch grouped B1 TK Bina Guna Terrain Academic Year 2015/2016. The subjects were children in group B1 amounted to 16 children. The results of the first cycle analysis of 16 children in the classical there are 4 children (25%) had cognitive abilities develop according to expectations, and 12 children (75%) have the cognitive abilities begin to develop value is 49.60. The second cycle of 16 children 4 children (25%) have the cognitive ability developed very well, 9 children (56%) had cognitive abilities develop according to expectations, and as many as three children (19%) had cognitive abilities began to grow with the average value of the class ie 68.36. Keywords: Traditional Games hopscotch, Cognitive Ability Abstrak : Penerapan Permainan Tradisional Engklek Dalam Meningkatkan Kemampuan Kognitif Anak Usia 5-6 Tahun Di TK Bina Guna. Tujuan penelitian untuk mengetahui peningkatan kemampuan kognitif anak melalui permainan engklek dikelompok B1 TK Bina Guna Medan Tahun Ajaran 2015/2016. Subjek penelitian adalah anak kelompok B1 berjumlah 16 anak. Hasil analisi siklus I dari 16 anak secara klasikal terdapat 4 anak (25%) memiliki kemampuan kognitif berkembang sesuai harapan, dan 12 anak (75%) memiliki kemampuan kognitif mulai berkembang dengan nilai yaitu 49,60. Siklus II dari 16 anak 4 anak (25%) memiliki kemampuan kognitif berkembang sangat baik, 9 anak (56%) memiliki kemampuan kognitif berkembang sesuai harapan, dan sebanyak 3 anak (19%) memiliki kemampuan kognitif mulai berkembang dengan nilai rata-rata kelas yaitu 68,36. Kata Kunci : Permainan Tradisional Engklek, Kemampuan Kognitif
Utilisation of Actiphage in combination with IS900 qPCR as a diagnostic tool for rapid determination of paratuberculosis infection status in small ruminant herds
Authors: Beinhauerova Monika , Slana Iva 
Published: July 2023

Abstract

Introduction

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis, a chronic infectious intestinal disease occurring in domestic and wild ruminants. Early diagnosis of infected herds enabling timely adoption of control measures is tremendously important in view of the fact that the disease has a significant economic impact on farmers. The aim of this study was to evaluate the possibility of rapid detection of viable MAP on small ruminant farms based on environmental sample examination using a novel phage-based test named Actiphage.

Material and Methods
A total of 9 fresh and 28 frozen (8 or 11 years at -70°C) environmental samples originating from paratuberculosis-affected farms were analysed for the presence of MAP by four different diagnostic methods: Actiphage combined with real-time PCR targeting insertion sequence 900 (IS900 qPCR), conventional phage amplification assay, culture (frozen samples only), and direct ĪS900 qPCR.

Results
Viable MAP was detected in one fresh environmental sample using Actiphage–IS900 qPCR. None of the frozen samples tested positive using this diagnostic approach, which was consistent with the results of culture examination also providing information on viability.

Conclusion
This study describes other possible and innovative uses of phage-based methods in paratuberculosis control strategies. The Actiphage-qPCR was found to be less laborious than culture and provided results within six hours, suggesting that it may be a valuable tool for rapid initial determination of the infectious status of farmed animals based on environmental sample examination.
Numerical Analysis of Resistance Characteristics of a Novel High-Speed Quadramaran
Authors: Liu Xin , Yang Jinglei , Wu Defeng , Hou Liang , Li Xiaowen , Wan Qian 
Published: July 2023

Abstract
This paper utilised computational fluid dynamics (CFD) technology to calculate the resistance of a novel high-speed quadramaran in calm water using the Navier‒Stokes (N‒S) equation, analysed the total resistance, frictional resistance, and residual resistance characteristics of this novel high-speed quadramaran at different length Froude numbers, and compared them with the results of a conventional high-speed catamaran with the same displacement. The results showed that the total resistance of the quadramaran had a significant hump at the Froude number of 0.6, due to the complexity of the wave interference among the four demihulls, and the hump value was about 1.6 times that of the catamaran. Above the hump speed, the total resistance of the quadramaran decreased with the increase of the Froude number, until reaching the Froude number of 1.06, when the curve became flat, and it showed a maximum resistance reduction of 40% at the Froude number of 1.66 compared with the catamaran, where the total resistance curve was steep. The frictional resistance of the quadramaran increased gradually with the growth of the Froude number, which was basically consistent with the change trend of the catamaran. The residual resistance of the quadramaran first rose and then reduced with the rising Froude number, the curve showed a large hump due to the adverse wave interference, and the hump value was about 1.7 times that of the catamaran. Above the Froude number of 1.06, as the wave interference changed from adverse to favourable, the quadramaran had lower residual resistance than the catamaran. The bow and stern demihulls of the quadramaran were also analysed for their resistance characteristics. The total resistance of the bow demihulls increased gradually with the increase of the Froude number, the curve had a small hump at the Froude number of 0.7, and above the hump speed, the curve was steep. The total resistance of the stern demihulls first increased and then decreased with the growth of the Froude number, the hump value at the Froude number of 0.85 was significant and was about 2 times that of the bow demihulls, and the curve became flat above the Froude number of 1.51.
Image Processing Method for Cargo Container Identification in a Stack Within the Cargo Temperature Control and Fire Safety System on Container Ships
Authors: Konon Vladyslav 
Published: July 2023

Abstract
The current research is focused on the identification of cargo containers in a stack from their images in the infrared and visible spectra, in order to locate the container-origin of ignition within the cargo temperature control and fire safety system. The relevance of the topic is reinforced by the functional requirements for shipboard safety, which are embodied in Chapter II-2 of the Safety of Life at Sea (SOLAS) Convention, and demanded by the necessity of enhancing safety measures during cargo transportation by the world container fleet. The thermal imager’s field of view (FOV) and the coordinate dependencies between the object and its image have been studied and modelled, and an algorithm for fire detection has been defined within the scope of the current research in connection with the containers within the camera’s FOV. A corresponding verification has been carried out by means of simulation modelling using the Unity and C# programming language capabilities.
Understanding Fuel Saving and Clean Fuel Strategies Towards Green Maritime
Authors: Nguyen Van Nhanh , Rudzki Krzysztof , Dzida Marek , Pham Nguyen Dang Khoa , Pham Minh Tuan , Nguyen Phuoc Quy Phong , Xuan Phuong Nguyen 
Published: July 2023

Abstract
Due to recent emission-associated regulations imposed on marine fuel, ship owners have been forced to seek alternate fuels, in order to meet the new limits. The aim of achieving low-carbon shipping by the year 2050, has meant that alternative marine fuels, as well as various technological and operational initiatives, need to be taken into account. This article evaluates and examines recent clean fuels and novel clean technologies for vessels. The alternative fuels are classified as low-carbon fuels, carbon-free fuels, and carbon neutral fuels, based on their properties. Fuel properties, the status of technological development, and existing challenges are also summarised in this paper. Furthermore, researchers have also investigated energy-saving devices and discovered that zero-carbon and virtually zero-carbon clean fuels, together with clean production, might play an important part in shipping, despite the commercial impracticability of existing costs and infrastructure. More interestingly, the transition to marine fuel is known to be a lengthy process; thus, early consensus-building, as well as action-adoption, in the maritime community is critical for meeting the expectations and aims of sustainable marine transportation.
Employee Productivity: Exploring the Multidimensional Nature with Acculturation, Open Innovation, Social Media Networking and Employee Vitality in the Indian Banking Sector: An Analytical Approach
Authors: Kumari Savita , Jindal Priya , Mittal Amit 
Published: July 2023

Purpose: The multi-dimensional nature of ‘employee productivity’ as a research construct needs extensive exploration, especially in view of the job-resources framework and in terms of stakeholder and accountability perspectives. The research study explored the topic with “individual” perceptions in exploring the pattern and tendency of the impact of acculturation and other organizational resources and protocols on the “perceived employee productivity”.

Theoretical framework: The theoretical implications of the research lie in the empirical exploration of the influences across employees, workplace-provided job resources, and contextual aspects that seem to shape the impetus for employee productivity.

Design/Methodology/Approach: The study delved into the aspects of ‘acculturation’, ‘open innovation’, ‘social media networking’, ‘employee vitality’, and ‘employee productivity’ for measuring the phenomenon in the Indian banking sector. The factors were operationalized with Likert scaling instruments and extractive factor analysis and structural equation modeling were leveraged.

Findings: The study observed a positive significant relationship among acculturation, open innovation, social media networking, employee vitality, and employee productivity in the Indian banking sector.

Research, Practical & Social implications: The research provides evidence that the organizational provision of job resources is a driving force behind the attainment of effective and sustainable employee productivity in the banking service sector. The research outcomes support and vindicate the prior research on the role of job resources in coping with workplace-derived uncertainties and exhibiting workplace productivity.

Originality/Value: The research outcomes illustrate the set of implications that possess meaning for core managerial application. The research has achieved the operationalization of employee productivity based on organizational support in the form of job resources.
PENGGUNAAN APLIKASI CLOUDX DAN QUIZZIZ UNTUK MENDUKUNG PEMBELAJARAN SEJARAH SECARA DARING
Authors: Marbun Tiarima 
Published: July 2023

This remote classroom action research (CAR) was conducted to improve learning outcomes through CloudX, an application media. The subjects of this study were high school students, XII IPS-3 SMA Negeri 2 Tarakan. They are 33 students, consisting of 12 male students and 21 female students. It was chosen since the students are solid and easy to cooperate. There are many problems in it, but the students are generally more responsive to the teacher. This classroom action research was conducted in two cycles with three teaching meetings in each. Both is designed to improve their learning outcomes using the CloudX. The results of the research prove that through the media can improve the students’ learning outcomes, as evidenced by the data in each aspect of observation. The action imlemented has been proved to have a good impact on the learning process. In the learning outcomes aspect, first cycle of meeting 1 showed 63.6% while in the second cycle of meeting 6 it increased to 90.9%% even though there were still 3 students or 9.1% had not achieved minimum completeness and 1 person was never present from the beginning research until the research is completed. Thus, the students who have not completed will be given remedial in a separate meeting in Google Classroom so as to achieve completeness in learning. Thus, learning using the CloudX has been proved to increase the student learning outcomes. It is recommended for teachers to use the CloudX Application in online learning.
Disease Modifying Therapies in Multiple Sclerosis: A Review
Authors: Raza Mohsin 
Published: July 2023

Multiple Sclerosis is a autoimmune demyelinating disease of the nervous system.This review paper evaluates disease modifying therapies for multiple sclerosis , a chronic autoimmune disease of the central nervous system. Over 20 Disease Modifying Therapies are available, categorized into injectables, oral agents, and infusions. The review covers their efficacy, safety, and tolerability. Established injectable Disease Modifying Therapies include interferon beta and glatiramer acetate, while newer oral agents like fingolimod offer conveniencewith more adverse effects. Infusions like natalizumab have higher efficacy but greater risks of adverse events. The paper also discusses newer Disease Modifying Therapies like cladribine. Treatment should be individualized based on patient characteristics, risk factors, and treatment goals. Overall, this review provides a comprehensive summary to aid clinicians in selecting appropriate Disease Modifying Therapies for Multiple Sclerosis.
Characteristics of the use of digital twins by industrial enterprises: the experience of foreign countries and Kazakhstan
Authors: Tashenova L.V. , Babkin A.V. , Mamrayeva D.G. , Kulzhambekova B.Sh. 
Published: July 2023

Object: digital twins, adapted to the tasks of industrial companies.
Methods: content analysis for the purpose of organizing and structuring the main scientific research related to the study of the use of digital twins, their role and importance for industrial companies; the analysis method that allowed to evaluate the current state of digitalization of production processes in companies; a graphic interpretation method that allowed to visualize the obtained results.
Findings: the concept of “digital twin” is considered and the aspects of its application in the sphere of industrial production are analyzed on the example of foreign companies and enterprises of Kazakhstan; the tasks of digital twins and the advantages of their implementation in production are pointed out; the stages of building digital twins were studied.
Conclusions: the study showed that the use of digital twins opens up new opportunities to improve the efficiency and competitiveness of an industrial company. The results provided an opportunity to assess the annually growing interest in the technology of digital twin; based on the analyzed sources, successful examples of the implementation of digital twins in the activities of industrial enterprises of foreign countries and Kazakhstan are considered.
Analysis of the experience of managing the development of giftedness in the education system
Authors: Karkulova А.А. , Satanov A.B. , Zhumageldi N.M. , Shakeyev S.S. 
Published: July 2023

Object: Based on the analysis of managerial experience in the development of giftedness in the education system of foreign countries, the article describes the models for the development of the education of gifted children adopted in the developed countries of the world. A working understanding of giftedness is defined at the present stage of the practice of implementing the education of the gifted in the conditions of Kazakhstani practice in the context of a specialized education system for gifted children. The possibility of using adapted organizational conditions for the development of specialized educational institutions for gifted children is substantiated.
Methods: Theoretical analysis of foreign research materials on the problem of the development of education for gifted children, analysis of the legislative framework of the Republic of Kazakhstan on the research problem.
Findings: The analysis of theoretical materials made it possible to identify the presence of problem areas – the lack of a unified understanding of giftedness in science, which led to the existence in practice of a large number of educational models for the development of gifted children in the developed countries of the world. The grounds for understanding giftedness in Kazakh science are revealed. We believe that the definition of giftedness should have a functional characteristic, which allows using an activity approach in working out a model for the development of the education of gifted children, as well as taking into account the direction of development of the activities of gifted people, focused on the tasks set for the development of state programs.
Conclusions: An analysis of models for the effective development of the education of gifted children, implemented in the developed countries of the world, is presented. We believe it is possible to develop an adaptive development model of the Kazakh model for the development of education for gifted children.