bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promotion of diced cartilage survival and regeneration with grafting of small intestinal submucosa loaded with urine‐derived stem cells
Authors: Li Shang , Wang Rui , Huang Liping , Jiang Yanlin , Xing Fei , Duan Weiqiang , Cen Ying , Zhang Zhenyu , Xie Huiqi 
Published: September 2023

AbstractCartilage absorption and calcification are prone to occur after the implantation of diced cartilage wrapped with autologous materials, as well as prolong the operation time, aggravate surgical trauma and postoperative pain during the acquisition process. Small intestinal submucosa (SIS) has suitable toughness and excellent degradability, which has been widely used in the clinic. Urine‐derived stem cells (USCs), as a new type of stem cells, have multi‐directional differentiation potential. In this study, we attempt to create the tissue engineering membrane material, termed USCs‐SIS (U‐SIS), and wrap the diced cartilage with it, assuming that they can promote the survival and regeneration of cartilage. In this study, after co‐culture with the SIS and U‐SIS, the proliferation, migration and chondrogenesis ability of the auricular‐derived chondrocyte cells (ACs) were significantly improved. Further, the expression levels of chondrocyte phenotype‐related genes were up‐regulated, whilst that of dedifferentiated genes was down‐regulated. The signal pathway proteins (Wnt3a and Wnt5a) were also participated in regulation of chondrogenesis. In vivo, compared with perichondrium, the diced cartilage wrapped with the SIS and U‐SIS attained higher survival rate, less calcification and absorption in both short and long terms. Particularly, USCs promoted chondrogenesis and modulated local immune responses via paracrine pathways. In conclusion, SIS have the potential to be a new choice of membrane material for diced cartilage graft. U‐SIS can enhance survival and regeneration of diced cartilage as a bioactive membrane material.
A single center Israeli experience in pregnancy post lung transplantation: Feasibility of successful two or more full‐term pregnancies in individual lung transplant recipients
Authors: Shtraichman Osnat , Heching Moshe , Bakal Ilana , Rosengarten Dror , Shitenberg Dorit , Shostak Yael , Barac Yaron D. , Peysakhovich Yury , Kramer Mordechai R. 
Published: September 2023

AbstractIntroductionFemale lung transplant recipients (LTRs) of reproductive age are increasingly considering pregnancy due to advances in post‐transplant management and improved survival. We report our experience with pregnancy in LTRs, with an emphasis on two or more successful full‐term pregnancies in individual transplant recipients.MethodsWe conducted a retrospective analysis of pregnancies in LTRs at our transplant center and collected maternal and fetal outcomes.ResultsIn our patient cohort, eight female LTRs conceived a total of 17 pregnancies, resulting in 13 newborns, 12 at full term, and 11 with a birth weight > 2.5 kg. Three of the LTRs had two or more successful full‐term pregnancies. LTRs required a significant tacrolimus dose increase to maintain target trough levels during pregnancy. Six recipients are currently clinically stable and active, three with lung function comparable to pre‐pregnancy values, and three with evidence of chronic lung allograft dysfunction (CLAD), but stable lung function. Two of the eight LTRs died subsequent to childbirth secondary to chronic respiratory failure due to CLAD, at a mean of 11 years post‐transplantation and a mean of 4.5 years after childbirth.ConclusionPregnancy following lung transplantation is feasible and can be achieved with acceptable maternal and newborn outcomes. Importantly, LTRs can successfully have two or more full‐term pregnancies.
Discussion forums and student engagement: A social network analysis perspective
Authors: Kumi Richard 
Published: September 2023

AbstractOnline courses frequently use discussion forums to enhance student engagement, an approach that is critical to fostering positive student learning outcomes. Because discussion forums are common in online classes, many instructors rely on summary statistics and self‐reported measures to assess student engagement. However, these metrics overlook the structural and relational dimensions of student interactions in discussion forums. To complement those other metrics, this study uses social network analysis to examine interactions in a discussion forum to expose the structural and relational dimensions of student interactions. We aggregated data on student interactions in a discussion forum for an undergraduate class with 31 enrolled students. The graphical representation of student interactions in the discussion forum revealed the social positions and roles of students and exposed the strengths and weaknesses in the structural and relational ties. Mathematical analysis accurately measures student interactions in the forum using measures of centrality. Both of those analyses enabled the description and comparison of interactions at the group and individual levels. Social network analysis is a practical method that adds another perspective to our understanding of student interactions in discussion forums. The outcomes of social network analysis can help instructors design courses, devise appropriate teaching interventions, and effectively use forums to engage students to improve learning outcomes.
Association between lactate/albumin ratio and prognosis in patients with acute myocardial infarction
Authors: Chen Yang , Lai Weiyan , Yang Ke , Wu Bingyuan , Xie Dongmei , Peng Chaoquan 
Published: September 2023

AbstractBackgroundThe association between the lactate/albumin ratio (L/A) as a diagnostic indicator and unfavourable clinical outcomes has been established in patients with community‐acquired pneumonia, sepsis and heart failure, but the connection between L/A and all‐cause mortality in patients with acute myocardial infarction (AMI) has yet to be fully understood.MethodsThis was a retrospective cohort study using MIMIC‐IV (v2.2) data, with 2816 patients enrolled and all‐cause mortality during hospitalization as the primary outcome. Kaplan–Meier (KM) analysis was used to compare the all‐cause mortality between high‐level and low‐level L/A groups. Receiver operating characteristic (ROC) curve, Restricted cubic splines (RCS) and Cox proportional hazards analysis were performed to investigate the relationship between L/A ratio and in‐hospital all‐cause mortality.ResultsL/A values were significantly higher in the non‐survivor groups than the survival groups (1.14 [.20] vs. .60 [.36], p < .05), and area under the ROC curve [.734 (95% confidence interval, .694–.775)] was better than other indicators. Data of COX regression analysis showed that higher L/A value supposed to be an independent risk factor for in‐hospital mortality. RCS analysis showed evidence of an increasing trend and a non‐linear relationship between L/A and in‐hospital mortality (p‐value was non‐linear <.05). KM survival curves were significantly lower in the high L/A group than the low L/A group (p < .001), and the former group had an increased risk of in‐hospital mortality compared with the latter one (Log Rank p < .001).ConclusionsL/A demonstrates significant independent predictive power for elevated all‐cause mortality during hospitalization in patients diagnosed with AMI.
Actor–partner effects of coping strategies on emotional exhaustion in dual‐earner couples
Authors: Osca Amparo , Heras‐Recuero Laura 
Published: September 2023

AbstractObjectiveThe objective of this study was to investigate the actor and partner effects of personal coping strategies (behavioral and emotional) on emotional exhaustion, directly and indirectly through work–family conflict, in dual‐earner couples, from a gender perspective.BackgroundPrevious studies support the relevance of personal coping strategies as resources that contribute to better performance in work and family roles and the well‐being of couples. However, few studies have incorporated partner effects and a gender perspective into the analysis.MethodUsing a sample of 131 dual‐earner heterosexual couples, actor–partner interdependence models were tested to analyze the impact of personal coping strategies on both couple members' emotional exhaustion.ResultsActor effects show no gender differences, as experienced work–family conflict increases emotional exhaustion in both couple members. However, mixed results were found for the partner effect. Women's coping strategies appeared to be negatively related to men's work–family conflict, which in turn was negatively related to women's emotional exhaustion. However, the reverse pattern was not observed: men's coping strategies were not related to women's conflict, nor did women's conflict levels affect their partners' emotional exhaustion.ConclusionsMen's and women's personal resources do not equally influence the distribution of roles within the couple or the partners' well‐being.ImplicationsAlthough role sharing reduces women's emotional exhaustion, it is essential to promote their careers. Their career advancement is a matter of justice and a source of benefits for their families.
Genetic sex determination improves Canadian Atlantic salmon (Salmo salar) population assessments
Authors: Robertson Martha J. , Lehnert Sarah J. , Kelly Nicholas I. , Hamilton Lorraine C. , Jones Ross A. , Levy Alex L. , Poole Rebecca , Burke Chantelle M. , Duffy Steven J. , Messmer Amber , Bradbury Ian R. 
Published: September 2023

AbstractEstimating egg deposition for Atlantic salmon population assessments is made difficult by their lack of sexual dimorphism prior to the autumn spawning season. We quantified the effect of sex misclassification from subjective examination of external morphology on egg deposition estimates in four Atlantic salmon populations across multiple years. Sex classification of Canadian salmon using the genetic sex marker (sdY) was accurate (>97%), whereas sex classification based on subjective examination of external morphology was inaccurate, with misclassification rates dependent on sea age, life history, and sampling season. Sex misclassification led to annual egg deposition estimates that ranged from −36% to +56%. We found that sex could not be discriminated based on measures of external morphology.
Collaborative study on the genetics of alcoholism: The strength of collaboration, team science, and longitudinal data
Authors: Ehringer Marissa A. 
Published: September 2023

AbstractThis issue contains a series of articles describing the various resources, studies, results, and future directions for the collaborative study on the genetics of alcoholism (COGA). The collaborative and integrative approach initiated by this group ~30 years ago serves as an excellent example of the strength of team science. Individually, various aspects of COGA would be limited in their impact toward improved understanding of alcohol use disorder. Collectively, their wholistic approach which spans deep longitudinal phenotypic assessments in families to include the application of large‐scale omics technologies and cell‐culture based molecular studies has demonstrated the power of working together.
Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR)
Authors: Roden Anja C , Judge Meagan , den Bakker Michael A , Fang Wentao , Jain Deepali , Marx Alexander , Moreira Andre L , Rajan Arun , Stroebel Philipp , Szolkowska Malgorzata , Cooper Wendy A 
Published: September 2023

AimsThymic epithelial tumours (TET), including thymomas and thymic carcinomas and thymic neuroendocrine neoplasms, are malignant neoplasms that can be associated with morbidity and mortality. Recently, an updated version of the World Health Organization (WHO) Classification of Thoracic Tumours 5th Edition, 2021 has been released, which included various changes to the classification of these neoplasms. In addition, in 2017 the Union for International Cancer Control (UICC) / American Joint Committee on Cancer (AJCC) published the 8th Edition Staging Manual which, for the first time, includes a TNM staging that is applicable to thymomas, thymic carcinomas, and thymic neuroendocrine neoplasms.Methods and ResultsTo standardize reporting of resected TET and thymic neuroendocrine neoplasms the accrediting bodies updated their reporting protocols. The International Collaboration on Cancer Reporting (ICCR), which represents a collaboration between various National Associations of Pathology, updated its 2017 histopathology reporting guide on TET and thymic neuroendocrine neoplasms accordingly. This report will highlight important changes in the reporting of TET and thymic neuroendocrine neoplasms based on the 2021 WHO, emphasize the 2017 TNM staging, and also comment on the rigour and various uncertainties for the pathologist when trying to follow that staging.ConclusionThe ICCR dataset provides a comprehensive, standardized template for reporting of resected TET and thymic neuroendocrine neoplasms.
La negociación colectiva en el trabajo doméstico y su contribución a la regulación y la formalización en Italia
Authors: SEIFFARTH Marlene 
Published: September 2023

ResumenLa negociación colectiva del trabajo doméstico es un fenómeno infrecuente y poco estudiado, pese a su importancia para la regulación y formalización del sector. Italia es uno de los países europeos con mayor número de trabajadores domésticos y uno de los pocos con convenio colectivo nacional. Los sindicatos y las asociaciones de familias empleadoras negocian convenios desde 1974. Los resultados de este estudio cualitativo basado en entrevistas a expertos ponen de manifiesto retos y limitaciones, pero también una formalización en curso del trabajo atípico en este sector pujante, dominado por trabajadoras migrantes, gracias a la negociación colectiva y al compromiso de los interlocutores sociales.
Financial Flexibility and Opportunity Capture: Bridging the Gap Between Finance and Strategy
Authors: Arbogast Stephen V. , Kumar Praveen 
Published: September 2023

Logically, the practice of corporate finance and corporate strategy should be closely coordinated, but in reality there remains a massive gap between the two. This can lead strategically oriented firms to de‐emphasize or even discard NPV. Neither financial theory nor competitive strategy has been very open to the economic value of investment opportunity capture. Strategy must recognize that financial flexibility provides powerful advantages and financial theory must evaluate entire strategic programs rather than discrete, stand‐alone projects.Necessarily, the financial discussion of cost of capital and capital structure has to change. The authors offer two specific concepts to bridge the Gap between Finance and Strategy:1) Reserve Financial Capacity is the annual sum of Free Cash Flow, Financing Flexibility and Cash Reserves over the period envisioned for strategy execution. Individual projects must belong to strategic programs in the sense that they either: 1) keep the base business running; 2) preserve an existing competitive position; or 3) form part of a program to enhance advantage or fashion a strategic breakout.2) Strategically Sustainable Cost of Capital is the true, blended cost of capital required to complete an entire capital program.These concepts provide financial rigor to firms with well‐defined strategies and allow managements to wield Financial Flexibility as a strategic weapon, creating options on unique buying opportunities, such as at the bottom of industry cycles.
An Improved Method for Valuing Mature Companies and Estimating Terminal Value
Authors: Holland David A. 
Published: September 2023

The theory underlying Discounted cash flow (DCF) models is uncontroversial in academia, the economic intuition behind them is straightforward, and the mathematics reassuringly simple. Nevertheless, in practice, they are applied inconsistently with very different valuation results. Because of the assumed infinite life (“going concern”) of a business enterprise, DCF models implicitly assume the ability to forecast future cash flows forever. This forces analysts to make assumptions about the terminal period using simplistic metrics such as P/E or EV/EBITDA to estimate terminal values or to embed a perpetual stream of excess profitability and value creation in the terminal period.The author offers an uncomplicated alternative to these unrealistic assumptions. The first step is to introduce an adjustable fade rate called f. A fade rate of 100% brings about immediate convergence, and a fade rate of 0% specifies no fade and perpetual excess profitability. The notion that excess profits get competed away over time can be modeled by assuming that the spread of (ROIC ‐ r) fades to zero and that economic profit dissipates.Intrinsic value is very sensitive to the fade rate assumption and this helps explain the risk premium for quality stocks. The risk of owning quality stocks is that they lose their economic moat and competitive advantage. An adjustable fade rate provides an excellent means to value the effect of profitability attenuation in a DCF model.
Emetine dihydrochloride alleviated radiation‐induced lung injury through inhibiting EMT
Authors: Wang Xin , Li Mo , Yin Jizhong , Fang Jiayan , Ying Yimeng , Ye Tianxia , Zhang Fangxiao , Ma Shumei , Qin Hongran , Liu Xiaodong 
Published: September 2023

AbstractRadiation‐induced lung injury (RILI), divided into early radiation pneumonia (RP) and late radiation‐induced pulmonary fibrosis (RIPF), is a common serious disease after clinical chest radiotherapy or nuclear accident, which seriously threatens the life safety of patients. There has been no effective prevention or treatment strategy till now. Epithelial‐mesenchymal transition (EMT) is a key step in the occurrence and development of RILI. In this study, we demonstrated that emetine dihydrochloride (EDD) alleviated RILI through inhibiting EMT. We found that EDD significantly attenuated EMT‐related markers, reduced Smad3 phosphorylation expression after radiation. Then, for the first time, we observed EDD alleviated lung hyperaemia and reduced collagen deposit induced by irradiation, providing protection against RILI. Finally, it was found that EDD inhibited radiation‐induced EMT in lung tissues. Our study suggested that EDD alleviated RILI through inhibiting EMT by blocking Smad3 signalling pathways. In summary, our results indicated that EDD is a novel potential radioprotector for RILI.
Improving the diagnosis of Streptococcus iniae using a novel probe‐based qPCR assay combined with an enrichment step
Authors: Phasunon Ramida , Taengphu Suwimon , Panphut Wattana , Chatchaiphan Satid , Dong Ha Thanh , Senapin Saengchan 
Published: September 2023

AbstractStreptococcus iniae is a bacterial pathogen that causes streptococcosis, leading to significant losses in fish aquaculture globally. This study reported a newly developed probe‐based quantitative polymerase chain reaction (qPCR) method for the detection of S. iniae. The primers and probes were designed to target the lactate oxidase gene. The optimized method demonstrated a detection limit of 20 copies per reaction and was specific to S. iniae, as evidenced by no cross‐reactivity when assayed against genetic materials extracted from 23 known aquatic animal pathogens, and fish samples infected with Streptococcus agalactiae or Streptococcus dysgalactiae. To validate the newly developed qPCR protocol with field samples, fish specimens were systematically investigated following the Food and Agriculture Organization of the United Nations & Network of Aquaculture Centres in Asia‐Pacific three diagnostic levels approach, which integrated basic and advanced techniques for disease diagnosis, including observation of gross signs (level I), bacterial isolation (level II), qPCR and 16S rDNA sequencing (level III). The result showed that 7/7 affected farms (three Asian seabass farms and four tilapia farms) experiencing clinical signs of streptococcosis were diagnosed positive for S. iniae. qPCR assays using DNA extracted directly from fish tissue detected S. iniae in 11 out of 36 fish samples (30.6%), while 24 out of 36 samples (66.7%) tested positive after an enrichment step, including apparently healthy fish from affected farms. Bacterial isolation of S. iniae was only successful in a proportion of clinically diseased fish but not in healthy‐looking fish from the same farm. Overall, the newly developed qPCR protocol combined with enrichment would be a useful tool for the diagnosis and surveillance of S. iniae infections in fish populations, thereby aiding in the disease control and prevention.
The associations among executive planning, self‐determination, and quality of life in adolescents with intellectual disability
Authors: Lui M. , Lau G. K. B. , Wong P. K. S. 
Published: September 2023

AbstractBackgroundSkills such as planning and problem solving that are required in self‐determination can be cognitively demanding. It has not yet been examined whether executive functions and intelligence are associated with levels of self‐determination in individuals with intellectual disability (ID), and how that is related to quality of life (QoL). This study examined the associations among executive functions, intelligence, self‐determination, and QoL in adolescents with ID.MethodsSeventy‐nine adolescents aged between 17 and 20 years with mild ID participated in the study. Executive functions were assessed by experimental tasks. Non‐verbal IQ and survey data regarding QoL and self‐determination capacity were collected from the participants.ResultsIn a regression model with QoL as the dependent variable, only executive planning and self‐determination capacity (but not working memory, inhibition and IQ) were significant predictors of QoL. Two mediation models were tested based on the hypotheses, literature and current findings. Model 1 revealed that executive planning had a negative direct effect on QoL when the mediator, self‐determination capacity, was held constant. Model 2 indicated that the significant association between self‐determination and QoL was not mediated by executive planning.ConclusionsThe findings highlighted the crucial significance of self‐determination, in comparison with executive functions and intelligence, for improving the QoL in adolescents with ID. Importantly, higher executive planning skill was even associated with lower QoL if self‐determination was not concurrently strengthened. These findings carry implications for the design of education and intervention programmes aimed at improving QoL of adolescents with ID.
Sunu Coosan: Creating “our tradition” in Senegalese wrestling songs
Authors: Brody Bina 
Published: September 2023

AbstractThis article explores the term “sunu coosan” as a Senegalese trope of self‐articulation and as a semiotic strategy in contemporary discourses surrounding nationhood. The term, meaning "our tradition" in Wolof, is used by professionals as well as lay people in their promotion of the national sport, Làmb wrestling. By examining this phrase within the broad repertoire of Senegalese wrestling songs, I show that the musical commentary performed in the sport of Làmb situates it within a narrative of traditional continuity, subsequently producing a modern tradition for the consumption of the Senegalese nation. I argue that this collection of songs is a performative embodiment of a modern state's struggle to form its national identity. In Senegal's national wrestling arenas, ongoing lyrical engagement with the themes of history, heritage, and morality in genre‐specific, stylized formats, makes these songs the site of both ‘traditional discourse’ and a ‘discourse about tradition’. In this article, I explore three central features of Làmb songs: the use of poetic personas; "out of time narration"; and the recitation of praise poetry. By implementing these stylistic techniques inside and outside of the arena, local musicians continually create a meta‐discourse about the meaning of tradition.