bluuebunny/crossref_metadata_2025_split huggingface dataset:
HAMBATAN IMPLEMENTASI SANKSI PIDANA REHABILITASI TERHADAP PENYALAHGUNA DAN PECANDU NARKOTIKA DALAM UPAYA MEMBERANTAS TINDAK PIDANA PENYALAHGUNAAN NARKOTIKA OLEH BADAN NARKOTIKA NASIONAL
Authors: Basworo Naufal Nabawi , Budyatmojo Winarno , Setiyanto Budi 
Published: May 2023

<p><strong>Abstrak</strong></p><p>Penelitian ini bertujuan untuk mengetahui hambatan yang didapati serta upaya apa yang dilakukan oleh Badan Narkotika Nasional dalam mengimplementasikan sanksi pidana rehabilitasi terhadap penyalahguna dan pecandu narkotika. Penulisan hukum ini menggunakan penelitian hukum dengan jenis metode penelitian empiris. Penelitian ini bersifat deskriptif dengan pendekatan kualitatif. Jenis dan sumber data yang digunakan dalam penelitian ini adalah data primer dan data sekunder. Teknik pengumpulan data melalui wawancara dan studi kepustakaan. Lokasi penelitian pada Badan Narkotika Nasional. Hasil penelitian ini, diketahui bahwa dalam mengimplementasikan sanksi pidana rehabilitasi terhadap penyalahguna dan pecandu narkotika terdapat beberapa hambatan yang ditemui oleh Badan Narkotika Nasional, seperti dalam problematika dalam peraturan tindak pidana narkotika, kurangnya sarana dan prasarana, serta pembiayaan. Dalam hal mengupayakan agar rehabilitasi dapat sesuai sasaran dan tujuan disamping hambatan yang ditemukan, Badan Narkotika Nasional tengah berupaya untuk mengajukan revisi Undang-Undang Nomor 35 Tahun 2009 Tentang Narkotika kepada presiden dan Dewan Perwakilan Rakyat, mengedukasi sumber daya manusia yang terdapat di Lembaga Permasyarkatan agar dapat melakukan rehabilitasi, serta meningkatankan anggaran rehabilitasi dan menyusun program-program rehabilitasi sesuai dengan anggaran.</p><p><strong>Kata Kunci :</strong> Implementasi, Rehabilitasi, Tindak Pidana Narkotika.</p><p><strong><em> </em></strong></p><p><strong><em>Abstract</em></strong></p><p><em>This study aims to determine the obstacles encountered and what efforts are made by the National </em> <em>Narcotics Board in implementing criminal sanctions for the rehabilitation of narcotics abusers and addicts. This legal writing uses legal research with the type of empirical research method. Data collection techniques through interviews and literature study. Research location at the National Narcotics Board. </em> <em>The results of this study, it is known that in implementing criminal sanctions for rehabilitation against </em> <em>narcotics abusers and addicts, there are several obstacles encountered by the National Narcotics Board, such as problems in the regulation of narcotics crime, lack of facilities and infrastructure, and financing. In terms of making the rehabilitation work according to the targets and objectives in addition to the obstacles found, the National Narcotics Board is trying to submit a revision of Law Number 35 of 2009 on Narcotics to the president and the House of Representatives, educating human resources in the Penitentiary carry out rehabilitation, as well as increase the rehabilitation budget and prepare rehabilitation programs according to the budget.</em></p><p><strong><em>Keywords : </em></strong><em>Narcotics Crime, Rehabilitation, Research.</em></p>
IKKα kinase coordinates BRD4 and STAT3 signaling to subvert DNA damage-based anticancer therapy
Authors: Pecharroman Irene , Sole Laura , Villanueva Daniel Alvarez , Bertran Joan , Guillén Yolanda , Lobo Teresa , Alonso-Marañon Josune , Martínez Maria , García-Hernández Violeta , Gimenez Gemma , Colomer Carlota , Mulero María Carmen , Gonzales Jessica , Salazar Ramon , Santos Cristina , Garrido Marta , Villanueva Alberto , Borràs Eva , Sabidó Eduard , Bonfill-Teixidor Ester , Iurlaro Raffaella , Montoto Angela , Seoane Joan , Iglesias Mar , Bigas Anna , Espinosa Lluis 
Published: May 2023

Abstract
Activation of the IKK kinase complex has recurrently been linked to colorectal cancer (CRC) initiation and progression. However, identification of downstream effectors other than NF-kB has remained elusive.
Analysis of IKK-dependent substrates after UV-treatment revealed that BRD4 phosphorylation by IKKa is required for chromatin-binding dynamics upon damage. Moreover, IKKa induces the NF-kB-dependent transcription of LIF leading to STAT3 activation, association of BRD4 to STAT3 and recruitment to specific target genes. IKKa abrogation results in defective BRD4 and STAT3 function leading to irreparable DNA damage and apoptotic cell death upon different stimuli. Simultaneous inhibition of BRAF-dependent IKKa activity and JAK/STAT pathway enhanced the therapeutic potential of 5-FU plus irinotecan in CRC patient-derived organoids and is curative in a chemotherapy-resistant CRC xenograft model. Coordinated expression of LIF and IKKa is a poor prognosis marker for CRC patients.
Our data uncover a functional link between IKKa, BRD4 and JAK/STAT signaling with clinical relevance.
Suicidality, depression, and anxiety among Hong Kong veterinarians: a quantitative pilot study
Authors: Chan Camille K.Y. , Wong Paul W.C. 
Published: May 2023

Abstract
Objective
The suicidality and poor mental health conditions of the veterinary profession have drawn increasing attention; however, little is known about the mental health status of veterinarians in Hong Kong. This study aimed to examine the prevalence of suicidality and symptoms of depression and anxiety among Hong Kong veterinarians.
Methods
All veterinarians were registered and practising in Hong Kong at the time of recruitment to the e-survey study between 1 January 2022 and 31 March 2022. Participants’ suicidality, depressive symptoms, and anxiety symptoms were assessed using validated scales.
Results
Data from 56 participants were included in the analysis. Among them, 22.0% self-reported as at risk of suicide, 19.6% had current suicidal ideation, 29.4% had depressive symptoms, 29.4% and anxiety symptoms, and 23.5% were comorbid with depression and anxiety. Our findings were comparable to or higher than those reported in Anglophone and European countries.
Conclusion
Contextual factors affecting the mental health of veterinarians practising in Hong Kong are worth further investigation. It is important to enhance mental health awareness by improving the profession’s mental health literacy as a suicide prevention strategy.
Sixteen-year longitudinal evaluation of blood-based DNA methylation biomarkers for early prediction of Alzheimer’s disease
Authors: Hackenhaar Fernanda Schäfer , Josefsson Maria , Adolfsson Annelie Nordin , Landfors Mattias , Kauppi Karolina , Porter Tenielle , Milicic Lidija , Laws Simon M. , Hultdin Magnus , Adolfsson Rolf , Degerman Sofie , Pudas Sara 
Published: May 2023

Abstract
Background: DNA methylation (DNAm), an epigenetic mark reflecting both inherited and environmental influences, has shown promise for AD prediction.
Objective: Testing long-term predictive ability (>15 years) of existing DNAm-based epigenetic age acceleration (EAA) measures and identifying novel early blood-based DNAm AD-prediction biomarkers.
Methods: EAA measures calculated from Illumina EPIC data from blood were tested with linear mixed-effects models (LMMs) in a longitudinal case-control sample (50 late-onset AD cases; 51 matched controls) with prospective data up to 16 years before clinical onset, and post-onset follow-up. Novel DNAm biomarkers were generated with epigenome-wide LMMs, and Sparse Partial Least Squares Discriminant Analysis applied at pre- (10-16 years), and post-AD-onset time-points.
Results: EAA did not differentiate cases from controls during the follow-up time (p-values>0.05). Three new DNA biomarkers showed in-sample predictive ability on average 8 years pre-onset, after adjustment for age, sex, and white blood cell proportions (p-values: 0.022-< 0.00001). Our longitudinally-derived panel replicated nominally (p=0.012) in an external cohort (n=146 cases, 324 controls). However, its effect size and discriminatory accuracy were limited compared to APOEε4-carriership (OR=1.38 per 1 SD DNAm score increase vs. OR=13.58 for ε4-allele carriage; AUCs=77.2% vs. 87.0%). Literature review showed low overlap (n=4) across 3275 AD-associated CpGs from 8 published studies, and no overlap with our identified CpGs.
Conclusions: The limited predictive value of EAA for AD extends prior findings by considering a longer follow-up time, and with appropriate control for age, sex, APOE, and blood-cell proportions. Results also highlight challenges with replicating discriminatory or predictive CpGs across studies.
Development and application of a quantitative index for predicting unsafe behavior of shop floor workers integrating cognitive failure reports and best worst method
Authors: Shakerian Mahnaz , Choobineh Alireza , Jahangiri Mehdi , Alimohammadlou Moslem , Hasanzadeh Jafar , Nami Mohammad 
Published: May 2023

Abstract
The reliability of shop floor workers, mostly as the last level of a socio-technical system, has been identified as an essential factor in complex systems. This study aimed to develop and apply a quantitative and applicable method to help safety practitioners to manage unsafe behavior in industrial systems. This work is a descriptive-analytical and cross-sectional study, which was conducted in an Iranian manufacturing company. A questionnaire with six main unsafe behavior scales was used to determine the participants’ unsafe behavior scores. Since the effect of each of the six scales on unsafe behavior occurrence was different, the scales were weighted using best-worst method (BWM). Finally, to determine a quantitative score for unsafe behavior of the workers, the total unsafe behavior index (USBItotal) score was computed. The maximum and minimum mean scores were 10.68 and 5.09 for routine violations (RVs) and exceptional violations (EVs), respectively. The present study introduced an innovative proactive tool to provide safety practitioners with a practical hint using a quantitative cost-effective accessible method for predicting cognitive unsafe behavior of shop floor workers.
Evolution of Multicomponent [Pd2ABCD] Cages
Authors: Wu Kai , Benchimol Elie , Baksi Ananya , Clever Guido 
Published: May 2023

Abstract
Self-assembled hosts, inspired by biological receptors and catalysts, show potential for sustainable synthesis, energy conversion and medicine. Implementing multiple functionalities in the form of distinguishable building blocks, however, is difficult without risking narcissistic self-sorting or statistical mess. We report a systematic series of integratively self-assembled heteroleptic cages in which two square-planar PdII cations are bridged by four different bis-pyridyl ligands A, B, C and D via synergistic effects to form a single isomer of lantern-shaped cage [Pd2ABCD] as exclusive product. This ultimate self-sorting goal, forming just one out of 55 possible structures, is reached under full thermodynamic control and can be realized progressively (by combining progenitors such as [Pd2A2C2] with [Pd2B2D2]), directly from ligands and PdII cations, or by mixing all four corresponding homoleptic cages. The rational design of complex multicomponent assemblies, allowing to incorporate chemical moieties in a modular approach, will advance the application level of functional nanosystems.
Modeling policy pathways to maximize renewable energy growth and investment in Democratic Republic of the Congo using OSeMOSYS
Authors: Dalder Jacob , Oluleye Gbemi , Yeganyan Rudolf , Tan Naomi , Cannone Carla , Howells Mark 
Published: May 2023

Abstract
Keeping global warming from evolving into irreversible climate disaster requires immediate and sustained decarbonization of global energy systems. Of urgent priority are the energy systems in low- and middle-income countries (LMICs) where billions of people are projected to gain energy access in the next several decades. Therefore, leapfrogging traditional fossil fuel-based electricity production in favor renewable energy technologies is a critical issue area for sustainability. In the Democratic Republic of the Congo, political and economic challenges mean $44B in external investment is required to achieve its 2030 emissions reduction targets. Additionally, RETs are often more expensive.
This study sought to generate, evaluate, and recommend possible national policies for the DRC government to implement to most effectively boost growth and investment in RETs. Financial incentives were identified as the policy type most practical for DRC. Modeling the resulting energy systems for policy pathways involving a 16% RET subsidy, a 70% fossil fuel tax, and both in combination relative to no-policy baseline scenarios, the scenarios including the tax had the lowest net costs and the highest proportion of RETs (above 90%). Additionally, despite current reliance on hydropower to fulfill 98% of its energy needs, hydropower plays a very minor role in all modeled scenarios. Finally, a post-modeling market potential assessment was performed on the technology that dominated off-grid supply across policy pathways: the 0.3 kW small solar home system (SHS). Based on learning rates for solar PV, demand for the small SHS system in DRC (>160 million units in total) was found to be sufficient to substantially reduce the unit cost as deployment scales.
Putting results into context, emissions reductions for the policy pathways were higher than a past study focused on distributed RETs in DRC, and system costs were 15% higher than estimated in other analysis. These results provide a novel contribution to the literature by demonstrating how financial incentive policies can influence RET uptake in DRC specifically. Ultimately, this study yielded four policy recommendations for the DRC government:
1. Pursue financial incentives to catalyze DRC’s renewable energy supply
2. Tax fossil fuel energy production
3. Re-evaluate focus on hydropower
4. Promote DRC as a healthy market for solar home systems
Knowledge of Obstetric Danger Signs and Birth Preparedness and Complications Readiness among Mobile Pokot Nomadic Pastoralists’ Pregnant Women in Tiaty Sub-County, Baringo County-Kenya
Authors: KIPTULON EVANS Kasmai , Orsolya Mate 
Published: May 2023

Abstract
Problem: Maternal mortality in Kenya remains unacceptably high. Mobile pastoralists communities, Pokot included take the greatest burden of these maternal deaths.Background Knowledge of obstetric danger signs is important for prevention of pregnancy and birth complications as it influences pregnant women to prepare for birth and complications.Aim To assess the level of knowledge of obstetrics danger signs and its effect on Birth Preparedness and complications Readiness among mobile Pokot nomadic pastoralists in Kenya.Methods A descriptive cross-sectional study was conducted among 275 Pokot nomadic pastoralists’ pregnant women using a multistage sampling technique. Chi square (X2) was used to test the association between categorical variables and a P-value of < 0.05 was considered significant.Findings: Majority of the women had high knowledge of obstetric danger signs. However, the level of Birth Preparedness and complication readiness was low.Discussion Knowledge of obstetric danger signs and birth preparedness and complication readiness remains a key subject in fight against maternal mortality especially in pastoralists and unsettled communities where services are unpredictable and disrupted by frequent movements.Conclusion Maternal mortality, which remains a major reproductive health concern in Kenya may be reduced through government and other stakeholders deliberate delivery of quality antenatal care targeting mobile Pokot and other pastoralists living in Kenya.
Are high frequency marsquakes caused by meteoroid impacts? Implications for a seismically determined impact rate on Mars
Authors: Zenhäusern Géraldine , Wojcicka Natalia , Stähler Simon , Collins Gareth , Daubar Ingrid , Knapmeyer Martin , Ceylan Savas , Clinton John , Giardini Domenico 
Published: May 2023

Abstract

The crater density on planetary surfaces is used to determine their ages throughout the solar system, which requires a model for the rate of meteorite impacts of different sizes. For craters smaller than 30 meters, this rate has been observed from the generation of new craters in repeated orbital images. For larger craters, the rate was extrapolated from the lunar surface ages, taking into account the atmospheric removal of small craters. It has been observed that both estimates do not match for crater diameters smaller than 30 meters. The NASA InSight seismometer SEIS provided a new independent constraint, when it recorded seismic signals of several impacts during its mission. These confirmed impacts are part of a larger class of marsquakes (Very High Frequency, VF), all of which have characteristics consistent with an impact origin. We show that these VFs are plausibly caused by meteorite impacts and derive the impact rate required to explain their numbers. An empirical scaling relationship is used to convert between seismic moment and crater diameter. We apply area and time corrections to derive a global impact rate and find that the derived rate is 210--290 craters >8m globally per year, consistent with previously published chronology model rates and above the rates derived from freshly imaged craters.
Identification of the trade-off between speed and efficiency in undulatory swimming using a bio-inspired robot
Authors: Anastasiadis Alexandros , Paez Laura , Melo Kamilo , Tytell Eric , Ijspeert Auke Jan , Mulleners Karen 
Published: May 2023

Abstract
Anguilliform swimmers, like eels or lampreys, are highly efficient swimmers. Key to understanding their performances is the relationship between the body's kinematics and resulting swimming speed and efficiency. But, we cannot prescribe kinematics to living fish, and it is challenging to measure their power consumption. Here, we characterise the swimming speed and cost of transport of a free-swimming undulatory bio-inspired robot as we vary its kinematic parameters, including joint amplitude, body wavelength, and frequency. We identify a trade-off between speed and efficiency. Speed, in terms of stride length, scales with the maximum tail angle, described by the newly proposed specific tail amplitude and reaches a maximum value around the specific tail amplitude of unity. Efficiency needs a whole-body motion, travelling wave-like kinematics, and lower specific tail amplitudes. Our results suggest that live eels choose efficiency over speed and provide insights into the key characteristics affecting undulatory swimming performance.
Next-LSTM: A novel LSTM-based Image Captioning technique
Authors: Singh Priya , Kumar Chandan , Kumar Ayush 
Published: May 2023

Abstract
Recently, Image Captioning has evolved into an immensely popular area in the field of Computer Vision. It strives to generate natural language sentences in order to describe the salient parts of a given image. Research in this area is active and various Machine learning-based Image Captioning models have been proposed in the literature. The main challenge with the existing approaches is effectively extracting image features to generate adequate image captions. Further, there is a need to improve the generalizability of the results on large and diverse datasets. In the current paper, a novel method framework, namely Next-LSTM is proposed for Image Captioning. It first extracts the image features using ResNeXt. It is a powerful convolution neural network-based model that is adopted for the first time in the Image Captioning domain. Later, it applies a Long-short term memory network on the extracted features to generate accurate captions for the images. The proposed framework is then evaluated on the benchmark Flickr-8k dataset on Accuracy. The performance of the proposed framework is also compared to the state-of-the-art approaches and it outperforms the existing approaches.
Vermicompost as an Alternative Substrate to Peat Moss for Strawberry (Fragaria Ananassa) in Hydroponic Culture
Authors: YEGANEH MAHSA AZIZI , SHAHABI ALI ASGHAR , EBADI ALI , ABDOOSI VAHID 
Published: May 2023

Abstract
Background: Consecutive droughts and quantitative and qualitative reduction of surface and underground water resources have caused an increase in greenhouse and hydroponic cultivation for most garden crops, including strawberries, in Iran. On the other hand, most of the inputs of greenhouse crops in Iran are imported. To possibility of replacing vermicompostwith peat moss under hydroponic cultivation, an experiment was done in a split plot based on randomized complete blocks design in three replications in Isfahan (Iran) Agricultural and Natural Resources Research Center in 2019. The main treatment was substrate at four levels included different levels of vermicompost (30 and 50%) and peat moss (30 and 50%) in combination with perlite and sub-treatment were Selva and Camarosa cultivars.
Results: The results showed that Camarosa in 50% perlite/ 50% peat moss and Selva in 50% perlite / 50% peat moss and 70% perlite /30% vermicompost had maximum yield.
Leaf number, chlorophyll index were the highest in Camarosa cultivar in peat moss substrates. Strawberry cultivars had the highest amount of root fresh weight, vitamin Cand soluble solids in substrates containing vermicompost. Camarosa in 50% perlite/ 50% peat moss and Selva in 50% perlite /50% vermicompost had maximumroot dry weight. Also The highest number of inflorescences was related to substrates containing peat moss and 70% perlite / 30% vermicompost. Maximum amount of fresh and dry weight of shoots were observed in 70% perlite/30% peat moss. Selva cultivar had more inflorescences (16.5%) than Camarosa and Camarosa cultivar produced more fresh and dry weight of shoots (16.5%, 23.01%) than Selva.
Conclusion:Both strawberry cultivars in vermicompost and peat moss beds were slightly different from each other, even in traits such as TSS, vitamin C, and root fresh weight, vermicompost was better than peat moss, so since vermicompost is more cost-effective and affordable compared to peat moss, so a slight reduction in some traits in vermicompost in comparison with peat moss, it is justified and can be recommended as an alternative to peat moss in Selva and Camarosacultivar.
Research trends on the relationship between air pollution and cardiovascular diseases in 2013-2022 – A scientometric analysis
Authors: Zheng Daitian , Yang Qiuping , Wu Jinyao , Tian Huiting , Ji Zeqi , Chen Lingzhi , Cai Jiehui , Li Zhiyang , Chen Yexi 
Published: May 2023

Abstract
Exposure to air pollution is linked with an elevated risk of cardiovascular diseases (CVDs) and CVDs-related death. Despite the increasing concern over this issue, there is a shortage of scientometric analysis on the subject in existing databases. Therefore, we propose a scientometric study to explore research hotspots and directions in this topical field over the past decade. The present study employed the core collection of Web of Science (WoS) to obtain all relevant publications. Subsequently, Excel, the Bibliometix R-package, CiteSpace, and VOSviewer were utilized to analyze literature information, encompassing but not limited to annual publications, highly cited papers and co-cited references, journals, authors, countries, organizations, and keywords. Research on air pollution and CVDs has remarkable increase over the past decade. The top researchers are Kan H, Brook RD, Peters A, and Schwartz J. The 3144 articles were published by 4448 institutions in 131 countries/regions. The leading countries are the USA and China. Environmental Research was the most published journal. Mortality, hospital admissions, oxidative stress, inflammation, long-term exposure, fine particulate matter, and PM2.5 are the top areas that merit further investigation and hold significant potential for advancing our understanding of the complex relationship between air pollution and CVDs.