bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Emerging Autonomous Legal Order of the Eurasian Economic Union
Authors: Karliuk Maksim 
Published: June 2023

In this original study of the Eurasian Economic Union, Maksim Karliuk assesses the law and dynamics of functioning of this international organization. Examining the Eurasian Economic Union as an attempt to encourage post-Soviet integration, this book addresses the problematic legal issues of the integration process. Using the legal order autonomy framework, Karliuk carefully selects and organizes the topics included to offer readers a clear, systematic account of the most significant concerns. As well as considering theoretical issues, Karliuk engages with practical solutions to the problems identified. Besides merely outlining the present, this book develops a framework to address gaps and failures in current integration efforts and encourages further research into the complexities of Eurasian integration in the future.
Point-of-Care Ultrasound (PoCUS) and Its Potential to Advance Patient Care in Low-Resource Settings and Conflict Zones
Authors: Dana Elad , Nour A.D. Mahamat , Kpa’Hanba Gombako A. , Khan James S. 
Published: June 2023

Abstract
Point-of-care ultrasound (PoCUS) is used by health care professionals of various specialties worldwide, with excellent results demonstrating significant potential to advance patient care. However, in low resource areas of the world, where other imaging modalities are scarce and the potential of handheld pocket-sized PoCUS devices with great versatility and increasing affordability seems most significant, its use is far from being widespread. In this report, our group of Chadian, Israeli, and Canadian physicians with experience in rural, military, and conflict zone medical aid, discusses the barriers to the implementation of PoCUS in low resource areas and offers potential solutions.
Embodiment of color metaphor: an image-based visual analysis of the Chinese color terms hēi ‘black’ and bái ‘white’
Authors: Dou Jinmeng , Liu Meichun , Chen Tong 
Published: June 2023

AbstractPerceptual information includes sensorimotor and emotional experience regarding the multimodality of the perceptual system. The current study provides an image-based visual analysis on the embodiment of color metaphors through the investigation of (i) the perceptual (dis)similarities between the literal and metaphorical meanings of the Chinese color terms hēi ‘black’ and bái ‘white’ and (ii) the influence of emotional valence on the degree of their perceptual (dis)similarities. Specifically, 24 concepts in three semantic domains were represented as eight-dimensional vectors based on the color information extracted from online images, including two color concepts of black and white, 20 abstract concepts referring to 8 metaphorical meanings of hēi and 12 metaphorical meanings of bái, and two abstract concepts referring to positive and negative affective polarity. Statistical analyses show that (i) the literal and metaphorical meanings of hēi and bái are perceptually distinguishable given their significant perceptual (dis)similarities and (ii) the observed perceptual distinguishability cannot be solely attributed to the (in)consistency of emotional valence associated with the senses. The present study provides nonlinguistic evidence for the embodiment of color metaphors in the Chinese context with an empirical approach that can simultaneously capture the metaphorical mappings and affective associations among cross-domain concepts with sensory data.
Acoustic cues to phrase and clause boundaries in infant-directed speech: Evidence from LENA recordings
Authors: WANG Tianlin , YU Elie ChingYen , HUANG Rong , LANY Jill 
Published: June 2023

AbstractInfant-directed speech (IDS) produced in laboratory settings contains acoustic cues, such as pauses, pitch changes, and vowel-lengthening that could facilitate breaking speech into smaller units, such as syntactically well-formed utterances, and the noun- and verb-phrases within them. It is unclear whether these cues are present in speech produced in more natural contexts outside the lab. We captured LENA recordings of caregiver speech to 12-month-old infants in daylong interactions (N = 49) to address this question. We found that the final positions of syntactically well-formed utterances contained greater vowel lengthening and pitch changes, and were followed by longer pauses, relative to non-final positions. However, we found no evidence that these cues were present at utterance-internal phrase boundaries. Results suggest that acoustic cues marking the boundaries of well-formed utterances are salient in everyday speech to infants and highlight the importance of characterizing IDS in a large sample of naturally-produced speech to infants.
A comparative review on the role of stimuli in idea generation
Authors: Blandino Graziana , Montagna Francesca , Cantamessa Marco , Colombo Samuele 
Published: June 2023

Abstract
This paper reports a systematic literature review with the aim of determining the role of stimuli and other factors, such as timing, the designers’ background, expertise, and experience, in the idea generation phase of conceptual design related to engineering and industrial design and architecture. “Stimulus” is a general expression for a source of information characterized by several features, including the source (internal or external), analogical distance (near or far), and form (textual, visual, or other). Several recent studies have been conducted on this topic involving neurophysiological measurements with significant results. This comprehensive review will help to determine if the neurophysiological results are consistent with those from protocol studies. This allows for determining how the features of stimuli affect – among the related factors – designers’ performance in idea generation. The literature search was carried out using the Snowball and PRISMA methods. A total of 72 contributions were selected from studies adopting protocol analysis or neurophysiological measurements. This study presents a framework to support the selection of stimuli most likely to maximize performance, based on the designer's background and expertise in the different idea generation metrics. The main findings of the framework suggest that visual stimuli enhance the creative performance of designers, regardless of their background, while textual stimuli foster the variety and quality of ideas, but only in engineering and industrial designers. Comparing the findings, the resulting framework reveals aspects of stimuli that require further investigation. These can be considered valuable insights for new directions for design research.
Neuroplasticity and cognitive reserve effects in the Caudate Nucleus of young bilingual adults
Authors: Gallo Federico , Terekhina Liliia , Shtyrov Yury , Myachykov Andriy 
Published: June 2023

AbstractThis study investigates bilingualism-induced neuroplastic and cognitive-reserve effects in the Caudate Nucleus (CN), a structure believed to support both bilingual language control and domain-general executive functioning. We computed a generalized bilingualism index incorporating several dimensions of bilingual experience in a sample of bilingual young adults and tested whether this index would predict behavioral executive performance (measured using a Flanker task) and volumetric differences in the CN. Moreover, we investigated whether bilingualism mitigates the relationship between CN volume and executive performance, a sign of cognitive reserve. Our results indicate that bilingualism facilitates executive performance and induces an inverted U-shaped neuroplastic trajectory in bilateral CN, consistently with the view that structural increases are replaced by functional improvements as bilingual experience progresses. The emergence of bilingualism-induced cognitive reserve effects in CN further supports the view that bilinguals rely progressively less on the availability of structural resources in the face of increased functional efficiency.
Paleo‐Permeability Structure of the Crustal Section of the Samail Ophiolite Based on Automated Detection of Veins in X‐Ray CT Core Images From the Oman Drilling Project
Authors: Akamatsu Y. , Katayama I. , Okazaki K. , Michibayashi K. 
Published: June 2023

AbstractTo assess the paleo‐permeability structure of oceanic crust, we used 3‐D X‐ray Computed Tomography (XCT) images to quantify the distribution and geometry of mineral veins in core samples from Oman Drilling Project Holes GT1A, GT2A, and GT3A, which correspond to the upper to lower crustal sections of the Samail ophiolite. We developed a new method that automatically detects veins in the XCT core images based on iterative adaption of the two‐step Hough transform combined with multiscale Hessian filtering for identifying an elongate structure. Application of the developed method allowed us to identify the geometry and Computed Tomography number of more than 1500 veins with millimeter‐scale apertures in core sections with a total length of ∼1,200 m. High‐CT (HCT) veins in the drilled cores can be related to relatively high‐temperature fluid circulation near the mid‐ocean ridge, whereas Low‐CT (LCT) veins can be related to subsequent low‐temperature fluid circulation. Applying fracture fluid‐flow models to the geometric information for the detected veins, we found that the HCT and LCT vein systems both yielded bulk permeability of 10−13–10−9 m2 for each hole. This indicates that millimeter‐wide fractures can control crustal‐scale permeability, even in the lower oceanic crust. However, these vein systems show different depth dependencies and anisotropies of permeability, possibly reflecting the different spatial variations of high‐ and low‐temperature fluid circulation in oceanic crust.
Ménec Fossae on Europa: A Strike‐Slip Tectonics Origin Above a Possible Shallow Water Reservoir
Authors: Matteoni Pietro , Neesemann Alicia , Jaumann Ralf , Hillier Jon , Postberg Frank 
Published: June 2023

AbstractFaults and fractures may emplace fresh material onto Europa's surface, originating from shallow reservoirs within the ice shell or directly from the subsurface ocean. Ménec Fossae is a region of particular interest as it displays the interaction of several geological features, including bands, double ridges, chaotic terrains, and fossae, within a relatively small area. These features might affect the emplacement of buried material and subsequent exposure of fresh volatiles, prime targets for the upcoming JUICE and Europa Clipper missions in order to assess Europa's astrobiological potential. Previous studies have already revealed that a deep central trough is present at Ménec Fossae, flanked by several subparallel minor troughs and by a few asymmetrical scarps with lobate planforms. The presence of such features has motivated this study, given its potential to provide clear indications on the tectonic regime involved. Through detailed geomorphological‐structural mapping using Galileo Solid State Imager data and terrain analysis on Digital Terrain Models, we could develop a novel hypothesis on the formation mechanisms that might have been involved in the study area. We propose that Ménec Fossae has been shaped by transtensional (strike‐slip with an extensional component) tectonic activity, as indicated by the orientation and relationship of the tectonic features present. Likely, such transtensional tectonism occurred above or associated with shallow subsurface water, consistent with the overall morphology and topography of the study area and the presence of chaotic terrains and double ridges. These results strengthen the case for widely distributed shallow water reservoirs within Europa's ice shell.
Investigating the Effects of Ionospheric Scintillation on Multi‐Frequency BDS‐2/BDS‐3 Signals at Low Latitudes
Authors: Liu Hang , Ren Xiaodong , Zhang Xiaohong , Mei Dengkui , Yang Pengxin 
Published: June 2023

AbstractIonospheric scintillation could seriously disrupt the signal tracking of the global navigation satellite systems (GNSS), further causing positioning accuracy degradation or unavailability. BeiDou navigation satellite system (BDS), a newly developed GNSS by China, has begun to provide global positioning, navigation, and timing service. The objective of the present study is to investigate the effects of ionospheric scintillation on BDS‐2 and BDS‐3 multi‐frequency signals. Ionospheric scintillation monitor receiver data from four monitors in Brazil were collected from October 2021 to May 2022. The results illustrate that S4(B2) and S4(B3) linearly increase with S4(B1) for S4(B1) ≤ 0.6, which is consistent with weak scattering theories, and average experimental ratios of S4(B2)/S4(B1), S4(B3)/S4(B1), and S4(B2)/S4(B3) are less than corresponding theoretical ones by 6.1%, 4.4%, and 1.9%, respectively. Meanwhile, as S4 values increase, lower‐frequency scintillation saturates earlier than higher ones, and the probability of ionospheric scintillation events on B2 and B3 signals is approximately twice (S4 ≥ 0.7) as B1 signals in the equatorial ionization anomaly (EIA) regions. To alleviate the undesirable effects of missing data on GNSS positioning, we first investigate the inter‐frequency relationship and distribution probability of two significant spectral parameters, that is, T (the spectral strength of the phase noise at 1 Hz) and p (the spectral slope of the phase power spectral density) in the tracking jitter model among three BDS frequencies. Results show that the performances among B1, B2, and B3 frequencies have a higher correlation respectively, and their values for B2 and B3 signals are more susceptible to be impacted by ionospheric scintillation.
A New Shear‐Velocity Model of Continental Australia Based on Multi‐Scale Surface‐Wave Tomography
Authors: Magrini Fabrizio , Kästle Emanuel , Pilia Simone , Rawlinson Nicholas , De Siena Luca 
Published: June 2023

AbstractThe Australian Seismological Reference Model (AuSREM) represents a state‐of‐the‐art geophysical synthesis of the Australian continent. To date, its shear‐wave component has limited resolution at lower‐crustal to uppermost‐mantle depths, where it is mainly constrained by sparse measurements collected at the local scale. In this study, we compile a large data set of surface‐wave phase velocities based on seismic ambient noise and teleseismic earthquakes, to produce Rayleigh and Love phase‐velocity maps of continental Australia in a broad period range (4–200 s). Via transdimensional Bayesian inversion, we translate the phase‐velocity maps into a 3‐D shear‐wave velocity model extending to 300 km depth. Owing to the unprecedented seismic coverage and to the joint use of ambient‐noise and teleseismic data, the retrieved model fills a tomographic gap in the known shear‐wave velocity structure of the continent, comprising lower‐crustal to uppermost mantle depths. Consistent with AuSREM, strong velocity heterogeneities in our model highlight the (faster) cratonic blocks and the (slower) sedimentary basins at upper‐crustal depths. At mantle depths, the most prominent feature of the continent is a large‐scale eastward decrease in shear‐wave velocity. We interpret our observations in light of the relevant literature, and produce depth maps of the Moho and lithosphere‐asthenosphere boundary (LAB). Notably, our LAB proxy features a stripe of thicker lithosphere extending to the east coast, which is not visible in the AuSREM LAB model. This observation supports the idea that lateral variations in lithospheric thickness control both the composition and volume of surface volcanism in eastern Australia.
Earthquakes Record Cycles of Opening and Closing in the Enhanced Seismic Catalog of the 2008 Okmok Volcano, Alaska, Eruption
Authors: Garza‐Girón Ricardo , Brodsky Emily E. , Spica Zack J. , Haney Matthew M. , Webley Peter W. 
Published: June 2023

AbstractSeismicity during explosive volcanic eruptions remains challenging to observe through the eruptive noise, leaving first‐order questions unanswered. How do earthquake rates change as eruptions progress, and what is their relationship to the opening and closing of the eruptive vent? To address these questions for the Okmok Volcano 2008 explosive eruption, Volcano Explosivity Index 4, we utilized modern detection methods to enhance the existing earthquake catalog. Our enhanced catalog detected significantly more earthquakes than traditional methods. We located, relocated, determined magnitudes and classified all events within this catalog. Our analysis reveals distinct behaviors for long‐period (LP) and volcano‐tectonic (VT) earthquakes, providing insights into the opening and closing cycle. LP earthquakes occur as bursts beneath the eruptive vent and do not coincide in time with the plumes, indicating their relationship to an eruptive process that occurs at a high pressurization state, that is, partially closed conduit. In contrast, VT earthquakes maintain a steadier rate over a broader region, do not track the caldera deflation and have a larger b‐value during the eruption than before or after. The closing sequence is marked by a burst of LPs followed by small VTs south of the volcano. The opening sequence differs as only VTs extend to depth and migrate within minutes of the eruption onset. Our high‐resolution catalog offers valuable insights, demonstrating that volcanic conduits can transition between partially closed (clogged) and open (cracked) states during an eruption. Utilizing modern earthquake processing techniques enables clearer understanding of eruptions and holds promise for studying other volcanic events.
Modeling E‐Region Artificial Periodic Inhomogeneity
Authors: Hysell D. L. , Rojas E. 
Published: June 2023

AbstractArtificial periodic inhomogeneity or API experiments were conducted at the HAARP facility in Gakona, Alaska, in October 2022. The experiments concentrated on measuring ionospheric irregularities induced in the E‐region. The irregularities exhibited characteristics regarding their occurrence altitudes, rise and fall times, and Doppler shifts comparable to results from experiments conducted previously at HAARP and elsewhere. The irregularities also occurred in discrete altitude bands. Seeking to quantify these results, we constructed a simple, one‐dimensional fluid model which includes the effects of HF wave heating (direct and indirect) together with electron and ion cooling and thermal conduction, ion production, loss, and diffusion. Critically, the model includes a potential solver and can represent the ambipolar electric field. The model produced API irregularities in three distinct altitude bands which decayed according to the ambipolar diffusion rate.
Controversies in CPT® coding in the neonatal intensive care unit: - critical vs. intensive care
Authors: Lakshminrusimha Satyan , Song Clara , Pearlman Stephen A. , Martin Gilbert , Duncan Scott 
Published: June 2023

AbstractProfessional reimbursement to neonatal providers is based on the level of Current Procedural Terminology (CPT®) coding in the NICU, newborn nursery and other areas where neonatal care is provided. Four levels of evaluation and management (E&M) care—critical, intensive, routine-hospital care or normal newborn care can be provided to neonates. The work relative value units (wRVUs) associated with these four levels of care vary widely. This manuscript provides a brief review of basic features associated with each of these four levels with a specific perspective on differences between critical and intensive care codes. Coding and billing are constantly evolving fields with significant variation in interpretation and readers are encouraged to review the current publications on CPT® coding and make an informed decision on the best codes to be used for their patients.
Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response
Authors: Chen Zhao , Lin Changyou , Pei Hong , Yuan Xiaomei , Xu Jia , Zou Mingwei , Zhang Xinyuan , Fossier Amber , Liu Meizhu , Goo Seungah , Lei Lei , Yang Jia , Novick Catherine , Xu Jiqing , Ying Ge , Zhou Zhihong , Wu Jianbo , Tang Chunyi , Zhang Wenying , Wang Zhenping , Wang Zhihao , Zhang Huitang , Guo Wenzhong , Hu Qidong , Ji Henry , Chen Runqiang 
Published: June 2023

AbstractChimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory molecules in the tumor microenvironment, leading to T-cell exhaustion. To overcome this limitation, we have developed a synthetic T-cell receptor (TCR) that targets programmed death-ligand 1 (PD-L1), a molecule that is widely expressed in various solid tumors and plays a pivotal role in T-cell exhaustion. Our novel TCR platform is based on antibody-based binding domain, which is typically a single-chain variable fragment (scFv), fused to the γδ TCRs (TCRγδ). We have utilized the T-cell receptor alpha constant (TRAC) locus editing approach to express cell surface scFv of anti-PD-L1, which is fused to the constant region of the TCRγ or TCRδ chain in activated T cells derived from peripheral blood mononuclear cells (PBMCs). Our results indicate that these reconfigured receptors, both γ-TCRγδ and δ-TCRγδ, have the capability to transduce signals, produce inflammatory cytokines, degranulate and exert tumor killing activity upon engagement with PD-L1 antigen in vitro. Additionally, we have also shown that γ-TCRγδ exerted superior efficacy than δ-TCRγδ in in vivo xenograft model.
Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer’s disease
Authors: Sideris-Lampretsas George , Oggero Silvia , Zeboudj Lynda , Silva Rita , Bajpai Archana , Dharmalingam Gopuraja , Collier David A. , Malcangio Marzia 
Published: June 2023

AbstractMusculoskeletal chronic pain is prevalent in individuals with Alzheimer’s disease (AD); however, it remains largely untreated in these patients, raising the possibility that pain mechanisms are perturbed. Here, we utilise the TASTPM transgenic mouse model of AD with the K/BxN serum transfer model of inflammatory arthritis. We show that in male and female WT mice, inflammatory allodynia is associated with a distinct spinal cord microglial response characterised by TLR4-driven transcriptional profile and upregulation of P2Y12. Dorsal horn nociceptive afferent terminals release the TLR4 ligand galectin-3 (Gal-3), and intrathecal injection of a Gal-3 inhibitor attenuates allodynia. In contrast, TASTPM mice show reduced inflammatory allodynia, which is not affected by the Gal-3 inhibitor and correlates with the emergence of a P2Y12−TLR4−microglia subset in the dorsal horn. We suggest that sensory neuron-derived Gal-3 promotes allodynia through the TLR4-regulated release of pro-nociceptive mediators by microglia, a process that is defective in TASTPM due to the absence of TLR4 in a microglia subset.