bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting SURgery with GEriatric Co-Management and AI (SURGE-Ahead): A study protocol for the development of a digital geriatrician
Authors: Leinert Christoph , Fotteler Marina , Kocar Thomas Derya , Dallmeier Dhayana , Kestler Hans A. , Wolf Dennis , Gebhard Florian , Uihlein Adriane , Steger Florian , Kilian Reinhold , Mueller-Stierlin Annabel S. , Michalski Christoph W. , Mihaljevic André , Bolenz Christian , Zengerling Friedemann , Leinert Elena , Schütze Sabine , Hoffmann Thomas K. , Onder Graziano , Andersen-Ranberg Karen , O’Neill Desmond , Wehling Martin , Schobel Johannes , Swoboda Walter , Denkinger Michael ,   for the SURGE-Ahead Study Group
Published: June 2023

Introduction
Geriatric co-management is known to improve treatment of older adults in various clinical settings, however, widespread application of the concept is limited due to restricted resources. Digitalization may offer options to overcome these shortages by providing structured, relevant information and decision support tools for medical professionals. We present the SURGE-Ahead project (Supporting SURgery with GEriatric co-management and Artificial Intelligence) addressing this challenge.

Methods
A digital application with a dashboard-style user interface will be developed, displaying 1) evidence-based recommendations for geriatric co-management and 2) artificial intelligence-enhanced suggestions for continuity of care (COC) decisions. The development and implementation of the SURGE-Ahead application (SAA) will follow the Medical research council framework for complex medical interventions. In the development phase a minimum geriatric data set (MGDS) will be defined that combines parametrized information from the hospital information system with a concise assessment battery and sensor data. Two literature reviews will be conducted to create an evidence base for co-management and COC suggestions that will be used to display guideline-compliant recommendations. Principles of machine learning will be used for further data processing and COC proposals for the postoperative course. In an observational and AI-development study, data will be collected in three surgical departments of a University Hospital (trauma surgery, general and visceral surgery, urology) for AI-training, feasibility testing of the MGDS and identification of co-management needs. Usability will be tested in a workshop with potential users. During a subsequent project phase, the SAA will be tested and evaluated in clinical routine, allowing its further improvement through an iterative process.

Discussion
The outline offers insights into a novel and comprehensive project that combines geriatric co-management with digital support tools to improve inpatient surgical care and continuity of care of older adults.

Trial registration
German clinical trials registry (Deutsches Register für klinische Studien, DRKS00030684), registered on 21st November 2022.
Therapeutic Banding for Bleeding Duodenal Lymphangiectasias: A Novel Approach
Authors: Duve Robert , Robillard Kevin , Kanehira Kazunori 
Published: June 2023

ABSTRACT
With endoscopic advancements, the number of detected intestinal lymphangiectasias has been on the rise. They are generally considered benign and incidental; occasionally, these lesions carry complications, and best management options need to be established. Bleeding intestinal lymphangiectasias should be considered a rare cause in the differential diagnosis for gastrointestinal bleeding. References in the literature primarily indicate surgical treatment in these situations. In this study, we report an uncommon case of a man with esophageal adenocarcinoma who developed acute gastrointestinal bleeding from duodenal lymphangiectasias that were successfully banded.
Sustainable Development in Danish Public Libraries
Authors: Skøtt Bo 
Published: June 2023

Abstract
In 2015, the United Nations adopted a program of principles, Agenda 2030, to create a more sustainable world and better the living conditions for people. In this ambition, culture plays a crucial role. As such, the world goals seem to be an obvious topic for Danish public libraries, but this has not been the case until recently.
This study is based on a mixed-method approach including document studies, semi-structured interviews, and participation in a practitioners’ conference. It finds that Danish librarians strive to make the world goals comprehensible and articulate the parent institution as local communicators. Libraries are shown to be correctives to current commercial structures, but apart from this display great variation in how far the various libraries are advanced in their sustainable transformation.
The study concludes that public libraries inform citizens about the ambition of the world goals as a starting point for adjustments in the citizens’ actions. Public libraries have ventured into unknown territory, where previous practices do not hold much status. Many library professionals lack this awareness, which is necessary for our understanding of the United Nations world goals as a library policy task.
CHATGPT and the Global South: how are journalists in sub-Saharan Africa engaging with generative AI?
Authors: Gondwe Gregory 
Published: June 2023

Abstract

Study purpose
This study explores the usage of generative AI tools by journalists in sub-Saharan Africa, with a focus on issues of misinformation, plagiarism, stereotypes, and the unrepresentative nature of online databases. The research places this inquiry within broader debates of whether the Global South can effectively and fairly use AI tools.

Design/methodology/approach
This study involved conducting interviews with journalists from five sub-Saharan African countries, namely Congo, DRC, Kenya, Tanzania, Uganda, and Zambia. The objective of the study was to ascertain how journalists in sub-Saharan Africa are utilizing ChatGPT. It is worth noting that this study is a component of an ongoing project on AI that commenced on September 19, 2022, shortly after receiving IRB approval. The ChatGPT project was initiated in January 2023 after discovering that our participants were already employing the Chatbot.

Findings
The study highlights that generative AI like ChatGPT operates on a limited and non-representative African corpus, making it selective on what is considered civil and uncivil language, thus limiting its effectiveness in the region. However, the study also suggests that in the absence of representative corpora, generative AI tools like ChatGPT present an opportunity for effective journalism practice in that journalists cannot completely rely on the tools.

Practical implications
The study emphasizes the need for human agencies to provide relevant information to the tool, thus contributing to a global database, and to consider diverse data sources when designing AI tools to minimize biases and stereotypes.

Social implications
The social implications of the study suggest that AI tools have both positive and negative effects on journalism in developing countries, and there is a need to promote the responsible and ethical use of AI tools in journalism and beyond.

Originality/value
The original value of the study lies in shedding light on the challenges and opportunities associated with AI in journalism, promoting postcolonial thinking, and emphasizing the importance of diverse data sources and human agency in the development and use of AI tools.
Pilipenkova Gora – eine Siedlung der Zarubincy-Kultur am Mittleren Dnjepr
Authors: Iarmulschi Vasile 
Published: June 2023

Zusammenfassung
Einer der wichtigsten Fundplätze der Zarubincy-Kultur im Gebiet des mittleren Dnjepr ist die Siedlung von Pilipenkova Gora. Sie liegt etwa 2,5 km südöstlich der Stadt Kaniw auf einer Landzunge am rechten Ufer des Dnjepr. Das Plateau, auf dem sich der Fundort befindet, umfasst eine Fläche von etwa 1,5 ha. Die Spuren der latènezeitlichen Siedlung erstrecken sich über das gesamte Gebiet des Vorgebirges. Pilipenkova Gora wurde 1945 bei einer von T. S. Passek durchgeführten Feldbegehung entdeckt. Im Jahr 1948 wurden hier archäologische Ausgrabungen durchgeführt, die die Identifizierung von drei (?) Wohnstrukturen ermöglichten, die der Zarubincy-Kultur zugeschrieben werden. Später, in den Jahren von 1966–1970, wurde die Siedlung von E. V. Maksimov ausgegraben und eine Fläche von 3000 m2 freigelegt. Als Ergebnis dieser archäologischen Untersuchungen wurden mehr als 30 Wohngebäuden und 100 Gruben aus der der jüngeren vorrömischen Eisen- und frühen Römischen Kaiserzeit entdeckt.
The Therapeutic Frequency Profile of Subthalamic Nucleus Deep Brain Stimulation in Rats Is Shaped by Antidromic Spike Failure
Authors: Cassar Isaac R. , Grill Warren M. 
Published: June 2023

The therapeutic mechanisms of subthalamic nucleus (STN) deep brain stimulation (DBS) may depend on antidromic activation of cortex via the hyperdirect pathway. However, hyperdirect pathway neurons cannot reliably follow high-stimulation frequencies, and the spike failure rate appears to correlate with symptom relief as a function of stimulation frequency. We hypothesized that antidromic spike failure contributes to the cortical desynchronization caused by DBS. We measuredin vivoevoked cortical activity in female Sprague Dawley rats and developed a computational model of cortical activation from STN DBS. We modeled stochastic antidromic spike failure to determine how spike failure affected the desynchronization of pathophysiological oscillatory activity in cortex. We found that high-frequency STN DBS desynchronized pathologic oscillations via the masking of intrinsic spiking through a combination of spike collision, refractoriness, and synaptic depletion. Antidromic spike failure shaped the parabolic relationship between DBS frequency and cortical desynchronization, with maximum desynchronization at ∼130 Hz. These findings reveal that antidromic spike failure plays a critical role in mediating the dependency of symptom relief on stimulation frequency.SIGNIFICANCE STATEMENTDeep brain stimulation (DBS) is a highly effective neuromodulation therapy, yet it remains uncertain why conventionally used stimulation frequencies (e.g., ∼130 Hz) are optimal. In this study, we demonstrate a potential explanation for the stimulation frequency dependency of DBS through a combination ofin vivoexperimental measurements and computational modeling. We show that high-frequency stimulation can desynchronize pathologic firing patterns in populations of neurons by inducing an informational lesion. However, sporadic spike failure at these high frequencies limits the efficacy of the informational lesion, yielding a parabolic profile with optimal effects at ∼130 Hz. This work provides a potential explanation for the therapeutic mechanism of DBS, and highlights the importance of considering spike failure in mechanistic models of DBS.
Ideación suicida en adolescentes y adultos jóvenes de América Latina y el Caribe: scoping review
Authors: Caro Delgado Angela Gissette , Ballesteros-Cabrera Magnolia del Pilar 
Published: June 2023

Objetivo Identificar factores sociales, interpersonales e individuales asociados a la ideación suicida en adolescentes y adultos jóvenes de América Latina y el Caribe.
Método El tipo de estudio corresponde a una scoping review. Se construyó una ecuación de búsqueda a partir de la estrategia PCC que incluye elementos relacionados con Participantes, Concepto y Contexto. La búsqueda se realizó en las bases de datos Scopus, SAGE y Embase durante los últimos 7 años.
Resultados Se analizaron un total de 44 artículos. La ideación suicida se relacionó con la regulación emocional, el estado de ánimo, el consumo de drogas, el género, los problemas económicos, el apoyo familiar, la violencia, la ruptura con la pareja romántica, la religión y el apoyo social.
Conclusiones Se identificó que los factores individuales vinculados con la ideación suicida son el afecto positivo bajo, el afecto negativo alto, el estado de ánimo deprimido, la ansiedad, la inteligencia emocional, el abuso de alcohol, el consumo de tabaco, la impulsividad, el género femenino y las conductas suicidas. Los factores sociales son el hambre, la pobreza, la violencia, los problemas económicos, la calidad de vida, la clase económica, la religión y el apoyo social limitado. Por último, los factores interpersonales son el apoyo y el funcionamiento familiar, el apoyo de personas significativas, el apoyo de la escuela y de amigos, la ruptura con la pareja romántica, el bajo apoyo de los padres.
Comparison of phenotypic properties of innate lymphoid cells at various stages of rheumatoid arthritis
Authors: Boeva O. S. , Kozlov V. A. , Sizikov A. E. , Korolev M. A. , Chumasova O. A. , Omelchenko V. O. , Kurochkina Yu. D. , Pashkina E. A. 
Published: June 2023

Autoimmune diseases currently take a leading place in terms of frequency of occurrence in the population, among which 1 percent is occupied by rheumatoid arthritis (RA). Remission in this type of disease is extremely rare and requires constant use of pharmacotherapy. Studying the pathogenesis of RA is necessary to study to search for new drug targets. It is known that T helpers 1 (Th) and Th17 are involved in the development of RA. However, some researchers suggest that ILCs play a role in the development of RA. ILCs are “innate analogues” of Th, due to the fact that this subpopulation synthesizes the same cytokines. ILC1 is innate analogs of Th1, ILC2-Th2, ILC3-Th17. ILCs are tissue-resident innate lymphoid cells that have functional diversity and regulate the direction of the immune response through the production of cytokines.We used peripheral blood mononuclear cells (PBMCs) from patients (n = 19) and conditionally healthy donors (n = 10) as material. The group of patients was divided biologic disease-modifying anti-rheumatic drugs (bDMARDs) and Metotrexate (MTX) and of stage of RA (early and very early arthritis, advanced and late). PBMCs were stained with monoclonal antibodies. ILCs were identified as Lin-CD127+, CD294+ILCs (ILC2) were measured in the general population, CD117-CD294-ILCs were identified as ILC1, and CD117+CD294-ILCs were identified as ILC3.We obtained the following results: ILC1 was significantly reduced in patients treated with MTX comparison with patients on bDMARDs and healthy donors. However, patients on MTX with advanced RA had low levels of ILC2 and ILC3 compared to patients on bDMARDs. ILC2 significantly increased in patients with early stages of RA comparison with patients with advanced RA. However, ILC1 was significantly reduced in patients treated with MTX, and ILC3 increased significantly in patients treated with MTX comparison with bDMARDs. Expression of PD1 on ILC1 was increased compared to patients treated with bDMARDs. However, ILC3 patients with advanced stages on MTX had increased expression of PD1 comparison with patients taking bDMARDs. The ILC3 of donors was significantly increased comparison with patients on bDMARDs.
Features of the frequency of occurrence of T-330G <i>IL2</i> gene polymorphism in patients with COVID-19
Authors: Ageeva E. S. , Ablaeva R. N. , Yatskov I. A. , Aleshina O. K. , Rymarenko N. V. , Beloglazov V. A. , Dyadyura E. N. 
Published: June 2023

SARS-CoV-2 infection is the etiopathogenetic factor of the new coronavirus infection. Susceptibility to the virus and, accordingly, the incidence differs in children and adults. On the one hand, this reflects the age-related features of the immune response. On the other hand, it is realized through the production of a number of cytokines, including IL-2, and reflects the genetically determined features of cytokine production. The aim of the study was to analyze the frequency of occurrence of T-330G polymorphic variants of the IL2 gene in patients with a new coronavirus infection. A total of 145 patients were examined, including 31.0% of children (n = 45) and 69.0% of adults (n = 100). The diagnosis of a new coronavirus infection was verified by RT-PCR confirming the presence of the SARS-CoV-2 virus and identifying clinical symptoms of an upper respiratory tract infection. The control group consisted of 50 healthy volunteer donors. Allele-specific PCR with electrophoretic detection in 3% agarose gel (Litech, Russia) was used to analyze the T-330G polymorphism of the IL2 gene. To compare the frequencies of allele combinations, the χ2 test and the odds ratio OR and (95% CI) were used.The dominant genotype in patients with COVID-19 was the heterozygous GT genotype of the T-330G polymorphism of the IL2 gene. In the group of children at risk of developing a new coronavirus infection, the GG genotype of the T-330G polymorphism of the IL2 gene was associated (31.1% in children and 18.0% in the control group, p < 0.05, OR = 2.047). While the homozygous TT genotype of the T-330G polymorphism of the IL2 gene was a protective genotype (its occurrence rate was 26.7% in patients, 54.0% in the control group, p < 0.05, OR = 0.315). In adults, the heterozygous GT genotype of the T-330G polymorphism of the IL2 gene was associated with the risk of developing a new coronavirus infection (in the group of patients – 44.0% versus control – 28.0%, p = 0.028, OR = 2.020). A low risk of developing the disease was associated with the homozygous TT variant of the T-330G polymorphism of the IL2 gene (in the group of patients 37.0% versus control – 54.0%, p = 0.024, OR = 0.500).The T-330G polymorphism of the promoter zone of the IL2 gene differently affects its production. The direction of the immune response and its effectiveness depend on the level of IL-2. Understanding the individual factors that determine the features of the immune response can help in understanding the mechanisms of development of COVID-19-associated diseases and the selection of approaches to personalized methods of their treatment.
Interplay between copper and cobalt in hematopoiesis and the impact of their deficiency on anemia development
Authors: Jiemuratova G. K. 
Published: June 2023

Hematopoiesis is a complex process that requires a specific set of blood components to function properly. Blood diseases can result from imbalances or deficiencies in these components. The body has physiological sensors that respond to environmental changes by maintaining elemental homeostasis. A deficiency in one micronutrient can lead to imbalances in others. The purpose of this study was to investigate the role and interaction of copper, cobalt, and iron in hematopoiesis and to determine the prevalence of anemia in children living in the Aral Sea region.A total of 1120 children and adolescents were examined, and their physical development was measured using anthropometric measurements and laboratory tests. Hair samples were analyzed to determine the children's micronutrient status. The results revealed that 78% of the children had a decrease in hemoglobin, and anemia was more prevalent in adolescents. A correlation was found between high growth and increased levels of erythrocytes and hemoglobin. The study also identified the most common hypomicroelementoses in the Aral Sea region, including copper deficiency in 98.4% of cases, cobalt deficiency in 92.1%, and zinc deficiency in 57.8%.The study also analyzed the ratio of trace elements, revealing an increased Fe/Cu and Fe/Cu ratio in all age groups. Imbalances and deficiencies in copper, cobalt, zinc, and manganese were found to contribute to the development of anemia in children. Hair analysis for trace elements was shown to be significant in the differential diagnosis and treatment of children with anemia.In conclusion, the study highlights the importance of maintaining a proper balance of trace elements in hematopoiesis. Deficiencies in copper, cobalt, zinc, and manganese can contribute to anemia in children, and hair analysis can be used to diagnose and treat the condition. Further research is needed to better understand the role of trace elements in hematopoiesis and their impact on human health.
Metalloproteinase 9 and its role in the pathogenesis of allergic diseases in children
Authors: Semernik O. E. , Lebedenko A. A. , Appoeva A. A. 
Published: June 2023

Metalloproteinases (MMP) play a significant role in the mechanisms of maintaining chronic inflammation and tissue remodeling. The study of concentration changes in these enzymes in the blood serum of children with allergopathology is of great practical and scientific interest.Objective: to study the role of MMP-9 in the pathogenesis of allergic diseases in children. 180 children aged from 1 to 18 years passed a comprehensive clinical and laboratory examination. This study included patients suffering from bronchial asthma (BA) (n = 54), atopic dermatitis (AD) (n = 54) and combination of these pathologies (n = 72). Serum levels of MMP9 were determined by enzyme immunoassay using Cloud-CloneCorp® test systems (USA).The analysis of the obtained data showed that among patients with the established diagnosis of BA, the maximum concentration of this cytokine was registered in children with a moderate course of the disease. The conducted correlation analysis showed the presence of a significant correlation between the severity of asthma and the level of control over the disease (r = 0.63). Similar data was obtained in patients with a combination of BA and AD. In children of this group, there was also a significant increase in serum MMP-9 compared with healthy patients (p = 0.015). The concentration of this matrix metalloproteinase in serum was slightly higher among children with polyvalent sensitization than in patients with monoallergic etiology of the disease (p = 0.272). The values of MMP-9 in patients with only skin manifestations of atopy were significantly higher than in the control group (p = 0.025).The data we obtained showed that all the patients we examined had a significant increase in the level of MMP-9 in the blood serum, which indicates an important role of this cytokine in the pathogenesis of allergic diseases in children.