bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Climate Impact Satisfaction with Life? An Australian Spatial Study
Authors: Lignier Phil , Jarvis Diane , Grainger Daniel , Chaiechi Taha 
Published: December 2022

AbstractIt is now widely acknowledged that climate change will have a considerable impact on various aspects of human existence, and this includes happiness and satisfaction with life. This study adds to the existing literature on the contribution of climate to well-being by exploring the interaction of various climate variables at the national and local levels while controlling for socioeconomic factors. Using climate data covering a 20-yr period and demographic data from the Household Income Labor Dynamics in Australia surveys, several ordinary least squares (OLS) models of interaction are developed to test the proposition that climate does influence life satisfaction. Geographically weighted regression is then applied to explore how the relationship between explanatory variables and life satisfaction varies across different regions of Australia. We find that overall rainfall, temperature, and sunshine have a small but significant effect on individual life satisfaction. The spatial analysis reveals a high level of nonstationarity in the way climate variables impact life satisfaction, suggesting that regional climate type may be an important element influencing the relationship. The understanding of this relationship may assist policy makers who develop resilience and adaptation strategies as we face the impacts of climate change.Significance StatementTo the best of our knowledge, this study is the first investigation of contributions of a wide range of climate factors to individual life satisfaction across a continent-size country that provides a novel spatial analysis of the variations in climate factor impact. The study shows that in regions with climatic conditions of high temperatures and prolonged dry periods, additional heat will adversely affect individual well-being. In view of the anticipated effects of climate change, this finding does not bode well for residents of areas that already have a hot and dry climate, as increasing temperatures and potentially longer droughts are likely to compromise their well-being. This study can inform policy making that considers adaptive climate change strategies for community well-being.
Middle managers’ ethos as an inner motive in developing a caring culture
Authors: Morvati Diako , Hilli Yvonne 
Published: December 2022

Background Middle managers play a key role in promoting a caring culture in nursing homes. However, there is limited knowledge about middle managers’ inner motives and their experiences of their responsibility in developing a caring culture. Research aim The aim of the study is to get a deeper understanding of middle managers’ motives and their experiences of their responsibility to develop a caring culture in nursing homes. Research design A qualitative design with a hermeneutic approach inspired by Gadamer was chosen which guided the interpretation of data. Qualitative semi-structured interviews were conducted. Participants and research context Data were collected from thirteen middle managers in nursing homes, in six municipalities in northern Norway in September and October 2021. Ethical considerations The study was approved by the Norwegian Centre for Research Data. Oral and written informed consent was obtained from participants. Findings The findings show that the middle managers had non- egoistic motives to promote a caring culture as expressed in their attitudes and actions. They felt responsible to promote a caring culture where both patients and staff experienced care and were respected and recognized as unique individuals. Middle managers as good role models are responsible for being present and raising awareness of the importance of care in the nursing home culture by systematically reflecting on care values. However, a strong focus on the financial and administrative demands limits the middle managers’ possibilities to promote a caring culture and prevented them from always acting as they wanted to act, which often causes moral distress. Conclusion Being in contact with inner motives, enables the leader to promote a homelike and caring culture where both patients and staff feels respected and recognized as unique individuals. This study highlights the importance of systematic reflection on caring values in nursing homes which leads to value awareness among all actors.
Relationship between anatomical injury site of rectus femoris muscle strain and time taken to return to play in Japanese professional soccer players
Authors: Shimozaki Kengo , Nakase Junsuke , Asai Kazuki , Yoshimizu Rikuto , Kimura Mitsuhiro , Kanayama Tomoyuki , Yanatori Yusuke , Tsuchiya Hiroyuki 
Published: December 2022

Purpose The rectus femoris has three myotendinous or myoaponeurosis junctions and causes three types of muscle strain anatomically. We aimed to investigate the anatomical injury site of the rectus femoris muscle strain in professional soccer players as well as the characteristic findings on magnetic resonance imaging (MRI) and to evaluate its relationship with the time taken to return to play at competition levels. Methods Thirteen Japanese professional soccer players who sustained injuries to the rectus femoris were included in this study. The mechanism of injury, anatomical injury site, severity, absence of hematomas, and time taken to return to competition were evaluated. Results Ten patients were injured while kicking and three while sprinting. The anatomical injury site was the origin aponeurosis in two cases, intramuscular tendon in eight cases, and distal aponeurosis in three cases. The severity was one-degree in three cases and two-degree in 10 cases. Hematomas were observed in five cases. Cases with injuries caused by sprinting, two-degree injuries, or clear hematomas were associated with significantly longer periods of return to play than the other cases. Additionally, patients with distal aponeurosis-type injuries tended to take a long time to return to the competition. Conclusions In rectus femoris muscle strain, it is important to evaluate the anatomical injury site, severity, and absence of hematomas on MRI. Not only the injury mechanism, a clear hematoma, and high severity but also distal aponeurosis injuries may be associated with long periods of return to play at competition levels.
Tolerability and efficacy of chemoimmunotherapy when administered with a corticosteroid-free anti-emetic regimen
Authors: Tieri Jay , Harris Brent , Melikian Lori , Bullington Susan , Naville-Cook Chad , Crawford Brooke 
Published: December 2022

Background The use of immune checkpoint inhibitors (ICIs) in combination with chemotherapy is commonplace. This study sought to determine whether the omission of corticosteroids from the antiemetic regimen in patients receiving chemoimmunotherapy changes control of nausea and time on ICI therapy. Methods This single-site, retrospective, observational study was conducted at Veteran Health Indiana, a level 1A Veterans Affairs tertiary care facility. All patients who received concurrent chemoimmunotherapy between January 1, 2018, and December 31, 2020, were included. The replacement of corticosteroids with olanzapine in chemoimmunotherapy regimens occurred on March 27, 2019. Outcomes were compared in patients who received corticosteroids as part of antiemetic prophylaxis versus patients in whom corticosteroids were omitted. Outcomes included the proportion of patients achieving an anti-nausea complete control response (CCR) or partial control response (PCR) with antiemetic prophylaxis, and the time on ICI therapy in months. Results Seventy-two patients received a chemotherapeutic agent with a concomitant ICI during the designated time frame and were included for anti-emetogenic and ICI efficacy analysis, 36 patients received corticosteroids with chemoimmunotherapy and 36 patients did not. CCR was achieved in 55.6% of patients who received corticosteroids and in 69.4% of patients who did not. PCR was 19.4% versus 25.0%, respectively. Removal of corticosteroids from chemoimmunotherapy regimens did not result in a significant difference in nausea control or time on ICI therapy. Conclusions Results suggest corticosteroids may be safely continued, or removed and replaced by other novel agents for chemotherapy-induced nausea and vomiting when administered with ICIs.
Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis
Authors: Longoni Giulia , Martinez Chavez Edgar , Young Kimberly , Brown Robert A , Bells Sonya , Fetco Dumitru , Kim Laura , Grover Stephanie A , Costello Fiona , Reginald Arun , Bar-Or Amit , Marrie Ruth Ann , Arnold Douglas L , Narayanan Sridar , Branson Helen M , Banwell Brenda L. , Sled John G , Mabbott Donald J. , Yeh E Ann 
Published: December 2022

Background: The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which can be applied to the study of the ON. Objective: The objective of this study was to investigate the presence of subclinical ON abnormalities in pediatric-onset MS by means of magnetization transfer saturation and evaluate their association with other structural and functional parameters of visual pathway integrity. Methods: Eleven youth living with pediatric-onset MS (ylPOMS) and no previous history of optic neuritis and 18 controls underwent standardized brain MRI, optical coherence tomography (OCT), Magnetoencephalography (MEG)-Visual Evoked Potentials (VEPs), and visual battery. Data were analyzed with mixed effect models. Results: While ON volume, OCT parameters, occipital MEG-VEPs outcomes, and visual function did not differ significantly between ylPOMS and controls, ylPOMS had lower MTsat in the supratentorial normal appearing white matter (−0.26 nU, p = 0.0023), and in both in the ON (−0.62 nU, p < 0.001) and in the normal appearing white matter of the optic radiation (−0.56 nU, p = 0.00071), with these being positively correlated (+0.57 nU, p = 0.00037). Conclusions: Subclinical microstructural injury affects the ON of ylPOMS. This may appear as MTsat changes before being detectable by other currently available testing.
“Shared care” through instant messaging updates in youth care; an interaction analysis
Authors: Sliedrecht Keun Young , Stommel Wyke , Schep Ellen 
Published: December 2022

In this article, we analyse WhatsApp interactions in a youth care setting. In family-style group care, young people temporarily live in the family of professional foster parents (PFP), while they regularly visit their birth parents (BPs). Our data consist of instant messaging of 11 pairs of PFPs and BPs during 2 months. Using Conversation Analysis (CA), we focused on the social interaction between BPs and PFPs, achieved in and through multi-modally constructed sequences of updates—responses. First, updates are used by BPs in the context of the transfer from the child from/to the PFP marking the transfer of responsibility for the child. Second, PFPs use images as updates to provide BPs quasi-primary access to the experiences of the child. Third, updates are given or elicited in the context of prior problems. Across these functions, we observe that while BPs work to display responsibility, PFPs subtly empower BPs as parents.
Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis
Authors: Zhou Mingfang , Li Bo , Chen Yaling , Wang Aqian , Zhu Yining , Li Yu , Su Hongling , Fan Jingchun , Zhang Yan , Cao Yunshan 
Published: December 2022

Background: Misdiagnosis and underdiagnosis of pulmonary hypertension caused by fibrosing mediastinitis (PH-FM) are considerably prevalent due to unspecific symptoms and as well as the lack of awareness of this fatal disease. Objectives: The aim of this study was to evaluate the diagnostic accuracy of the chest X-ray (CXR) for screening the patients with PH-FM from those with pulmonary hypertension (PH). Design: This was a retrospective observational cohort study. Methods: The patients with suspected PH were recruited between October 2014 and October 2020. All the clinical data and CXR findings were collected. The sensitivity, specificity, and likelihood ratio of the CXR features were calculated. Logistic regression was used to identify the factors associated with the CXR characteristics and FM and to generate a prediction model. Finally, the diagnostic efficiency of the prediction model was evaluated using nomogram and internal validation. Results: The patients with PH-FM ( n = 36) and PH caused by the diseases other than FM (PH-non-FM, n = 62) were enrolled. The CXR features, including atelectasis, pleural effusion, consolidation, nodules, calcification, interlobular septal thickening, and interstitial reticulation, were more prevalent in patients with PH-FM than in those with PH-non-FM (all p < 0.05). Atelectasis had a specificity of 97%, a sensitivity of 50%, and a greater accuracy for diagnosing of PH-FM [area under the curve (AUC) = 0.720; 95% CI: 0.634–0.806] than the other factors did. The combination of tuberculosis, natural logarithmic NT-proBNP (lnBNP), atelectasis, pleural effusion, and prominent right heart border constituted a prediction model to distinguish the PH-FM from the PH-non-FM, with a sensitivity of 91.7% and a specificity of 83.9%. The model demonstrated good prediction performance by showing an AUC of 0.922 (95% CI: 0.861–0.983) in the internal validation. Conclusion: In this study, atelectasis was the most specific and accurate CXR characteristic for identifying PH-FM in the PH patients. The combination of atelectasis, pleural effusion, prominent right heart border, tuberculosis, and lnBNP constituted a prediction model that distinguished the PH-FM patients from the PH-non-FM ones with good performance.
Crystal structures of rhodium-containing erlichmanite–laurite solid solutions (Os1–x–yRuxRhyS2: x = 0.09–0.60, y = 0.07–0.10) with unique compositional dependence
Authors: Kitahara Ginga , Yoshiasa Akira , Ishimaru Satoko , Terai Kunihisa , Tokuda Makoto , Nishio-Hamane Daisuke , Tanaka Takahiro , Sugiyama Kazumasa 
Published: December 2022

AbstractRh-rich and Ir-poor erlichmanite–laurite OsS2–RuS2 solid solutions have been discovered at placers in Haraigawa, Misato-machi, Kumamoto, Japan. Microprobe analysis was performed to identify solid solutions containing few sub-components other than Rh. Approximately 10 at.% Rh was found to be present in the solid-solution samples. Structural refinement was performed using four natural samples: Os0.32Ru0.61Rh0.07S2, Os0.49Ru0.43Rh0.08S2, Os0.58Ru0.33Rh0.08S2 and Os0.81Ru0.09Rh0.10S2. The unit-cell parameters for the solid solutions containing Rh from Haraigawa varied from 5.61826(6) to 5.63142(8) Å. The (Os, Ru, Rh)–S distances in the Os1–x–yRuxRhyS2 system were almost constant with a small variation of 0.001 Å. Conversely, the S–S distances varied significantly, with variations approaching 0.1 Å. Rh substitution of Os rather than Ru had a larger impact on the crystal structure. The atomic displacement ellipsoid of both cations and anions was almost spherical, and no elongation along the M–S and S–S bond directions was observed. The bulk Debye temperatures were estimated from the Debye–Waller factor for the sulfide site. The bulk Debye temperatures of pure OsS2 and RuS2 were 688 K and 661 K, respectively, which suggests that the melting point of erlichmanite is higher than that of laurite. The high Debye temperature of OsS2 is inconsistent with the crystallisation of laurite prior to erlichmanite from the primitive magma, which suggests that $f_{\rm S_2}$, rather than temperature, is the main cause of the known crystallisation order. The presence of several percent Rh has a significant effect on the thermal stability of OsS2 and lowers the melting point of the erlichmanite solid solution compared to that of the laurite solid solution.
The electronic tree of life (eToL): a net of long probes to characterize the microbiome from RNA-seq data
Authors: Hu Xinyue , Haas Jürgen G. , Lathe Richard 
Published: December 2022

Abstract
Background
Microbiome analysis generally requires PCR-based or metagenomic shotgun sequencing, sophisticated programs, and large volumes of data. Alternative approaches based on widely available RNA-seq data are constrained because of sequence similarities between the transcriptomes of microbes/viruses and those of the host, compounded by the extreme abundance of host sequences in such libraries. Current approaches are also limited to specific microbial groups. There is a need for alternative methods of microbiome analysis that encompass the entire tree of life.

Results
We report a method to specifically retrieve non-human sequences in human tissue RNA-seq data. For cellular microbes we used a bioinformatic 'net', based on filtered 64-mer sequences designed from small subunit ribosomal RNA (rRNA) sequences across the Tree of Life (the 'electronic tree of life', eToL), to comprehensively (98%) entrap all non-human rRNA sequences present in the target tissue. Using brain as a model, retrieval of matching reads, re-exclusion of human-related sequences, followed by contig building and species identification, is followed by confirmation of the abundance and identity of the corresponding species groups. We provide methods to automate this analysis. The method reduces the computation time versus metagenomics by a factor of >1000. A variant approach is necessary for viruses. Again, because of significant matches between viral and human sequences, a 'stripping' approach is essential. Contamination during workup is a potential problem, and we discuss strategies to circumvent this issue. To illustrate the versatility of the method we report the use of the eToL methodology to unambiguously identify exogenous microbial and viral sequences in human tissue RNA-seq data across the entire tree of life including Archaea, Bacteria, Chloroplastida, basal Eukaryota, Fungi, and Holozoa/Metazoa, and discuss the technical and bioinformatic challenges involved.

Conclusions
This generic methodology is likely to find wide application in microbiome analysis including diagnostics.
High prevalence of dyslipidaemia among persons with diabetes mellitus and hypertension at a tertiary hospital in Blantyre, Malawi
Authors: Katundu Kondwani G. H. , Mukhula Victoria , Phiri Tamara , Phiri Chimota , Filisa-Kaphamtengo Florence , Chipewa Pascal , Chirambo George , Mipando Mwapatsa , Mwandumba Henry C. , Muula Adamson S. , Kumwenda Johnstone 
Published: December 2022

Abstract
Background
Dyslipidaemia drives the process of atherosclerosis, and hence a significant modifiable risk factor complicating hypertension and diabetes. In Malawi, the prevalence, screening and management of dyslipidaemia among persons with diabetes mellitus have not been reported. This study aimed to investigate the prevalence, biochemical characteristics, screening and management practices for dyslipidaemia among persons with diabetes mellitus, hypertension, and diabetes mellitus and hypertension comorbidity at Queen Elizabeth Central hospital in Blantyre, Malawi.

Methods
This was a cross-sectional study conducted in 2021. A total of 256 adult participants (diabetes mellitus = 100); hypertension = 100; both conditions = 56) were included. Medical data and anthropometric measurements were recorded. Blood samples were analysed for HbA1C and serum lipids. Associated risk factors for dyslipidaemia were also assessed.

Results
Dyslipidaemia was prevalent in 58%, 55%, and 70% of participants with diabetes mellitus, hypertension, and both conditions. Low-density lipoprotein cholesterol (LDL-C) dyslipidaemia was the most common in all participant groups. Participants with both diabetes and hypertension had 2.4 times (95% CI 1.2–4.6) increased risk of LDL-C dyslipidaemia than those with diabetes alone (p < 0.02). Being overweight or obese and age over 30 years were risk factors for dyslipidaemia in participants with diabetes mellitus alone (OR 1.3 (95% CI 1.1–1.6), p < 0.04, and OR 2.2 (95% CI 1.2–4.7) (p < 0.01), respectively. Overweight and obesity predicted LDL-C dyslipidaemia in hypertensive patients (OR 3.5 (95% CI 1.2–9.9) p < 0.001). Poorly controlled hypertension and the use of beta-blockers and thiazide diuretics predicted dyslipidaemia among patients with both diabetes mellitus and hypertension (OR 6.50 CI 1.45–29.19; and OR 5.20 CI 1.16–23.36 respectively). None of the participants had a lipogram performed before the study or were on lipid-lowering therapy.

Conclusions
Dyslipidaemia with LDL-C derangement was highly prevalent, especially in individuals with both diabetes mellitus and hypertension, and there was absent use of lipid-lowering therapy. Screening and managing dyslipidaemia should be reinforced to reduce the risk of cardiovascular complications in this population at increased risk.
A novel missense mutation of the STK11 gene in a Chinese family with Peutz-Jeghers syndrome
Authors: Yu Zhen , Liu Lin , Jiang Fang , Ji Yimin , Wang Xiao , Liu Lili 
Published: December 2022

Abstract
Background
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease caused by mutations in the Serine-Threonine Kinase 11 (STK11) gene. This study aimed to diagnose a Chinese pedigree with PJS and to expand the spectrum of STK11 variants.

Methods
We performed an inductive analysis of clinical features, gastrointestinal endoscopy, radiologic imaging, and pathological findings in a Chinese family with PJS. Whole-exome sequencing (WES), Sanger sequencing, and STK11 protein 3D structure prediction were performed for establishing a molecular diagnosis.

Results
The proband, her mother, and grandfather presented with pigmentation spots on lips, oral mucosa, and fingers. Her mother and grandfather also had pigmentation spots on face and feet, while her brother had pigmentation spots only on the lower lip. On endoscopy, polyps were discovered in the proband, her mother, and grandfather. A novel heterozygous mutation (c.521A > C) in exon 4 of STK11 was identified in all four patients, leading to a change from histidine to proline in amino acid 174. The variable site p.H174 was highly conserved in different species on multiple sequence alignment analysis.

Conclusions
We diagnosed a Chinese pedigree with PJS based on clinical features, gastrointestinal endoscopy, and genetic testing results. Our results expanded the spectrum of STK11 variants, which will be helpful for genetic counseling.