bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergent patterns of reef fish diversity correlate with coral assemblage shifts along the Great Barrier Reef
Authors: González-Barrios F. Javier , Keith Sally A. , Emslie Michael J. , Ceccarelli Daniela M. , Williams Gareth J. , Graham Nicholas A. J. 
Published: January 2025

Abstract
Escalating climate and anthropogenic disturbances draw into question how stable large-scale patterns in biological diversity are in the Anthropocene. Here, we analyse how patterns of reef fish diversity have changed from 1995 to 2022 by examining local diversity and species dissimilarity along a large latitudinal gradient of the Great Barrier Reef and to what extent this correlates with changes in coral cover and coral composition. We find that reef fish species richness followed the expected latitudinal diversity pattern (i.e., greater species richness toward lower latitudes), yet has undergone significant change across space and time. We find declines in species richness at lower latitudes in recent periods but high variability at higher latitudes. Reef fish turnover continuously increased over time at all latitudes and did not show evidence of a return. Altered diversity patterns are characterised by heterogeneous changes in reef fish trophic groups across the latitudinal gradient. Shifts in coral composition correlate more strongly with reef fish diversity changes than fluctuations in coral cover. Our findings provide insight into the extent to which classic macroecological patterns are maintained in the Anthropocene, ultimately questioning whether these patterns are decoupling from their original underlying drivers.
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates
Authors: Cross Robert W. , Woolsey Courtney , Prasad Abhishek N. , Borisevich Viktoriya , Agans Krystle N. , Deer Daniel J. , Harrison Mack B. , Dobias Natalie S. , Fenton Karla A. , Cihlar Tomas , Nguyen Anh-Quan , Babusis Darius , Bannister Roy , Vermillion Meghan S. , Chu Victor C. , Geisbert Thomas W. 
Published: January 2025

Abstract
The recent outbreak of Marburg virus (MARV) in Rwanda underscores the need for effective countermeasures against this highly fatal pathogen, with case fatality rates reaching 90%. Currently, no vaccines or approved treatments exist for MARV infection, distinguishing it from related viruses like Ebola. Our research demonstrates that the oral drug obeldesivir (ODV), a nucleoside analog prodrug, shows promising antiviral activity against filoviruses in vitro and offers significant protection in animal models. In this study with cynomolgus macaques (n=6), a 10-day regimen of once-daily ODV, initiated 24 hours post-exposure, provided 80% protection against a thousand-fold lethal MARV challenge, delaying viral replication and disease onset. Transcriptome analysis revealed that early adaptive responses correlated with successful outcomes. Compared to intravenous options, oral antivirals like ODV offer logistical advantages in outbreak settings, enabling easier administration and broader contact coverage. Our findings support ODV's potential as a broad-spectrum, oral postexposure prophylaxis for filoviruses.
Porous carbons with complex 3D geometries via selective laser sintering of whey powder
Authors: Llamas-Unzueta Raúl , Reguera-García Alejandro , Montes-Morán Miguel A. , Angel Menéndez J. 
Published: January 2025

Abstract
In addition to the inherent limitations of carbons to melt or flow, a vast majority of carbon precursors deforms during carbonisation, with stereolithography of thermoset resins being the preferred technology for 3D printing of carbons. An alternative is now presented with the possibility of using a melting-based technology, selective laser sintering (SLS), to fabricate 3D structures that withstand carbonisation. The key factor that makes this happen is whey powder, a natural, abundant and cheap by-product of the dairy industry. When heating the whey powder with a laser at 180–200 ºC for a few seconds, whey particles sinter, and 3D structures are obtained layer-by-layer. Carbonisation of the sintered whey structures brings about 3D porous carbons with excellent mechanical properties that preserve the SLS printed form albeit an isotropic shrinkage (approx. 23%). Melanoidins are identified as responsible for both the sintering and the thermoset behaviour during carbonisation of the whey powder.
Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study
Authors: Malky Islam El , Aita Wael Elshazly , Elkordy Alaa , Nasreldeen Marwa , Abdelhafiz Mahmoud , Tael Amr M. , Abdelkhalek Hazem Mo. 
Published: January 2025

Abstract
The most common diagnostic error of IIH is inaccurate funduscopic examination. Moreover, IIH could be diagnosed without papilledema. Trans orbital sonography could be used as a non-invasive and cheap tool for discovering increased ICP (intracranial Pressure). Aim of our study was discovering the changes in ultra-sonographic indices and which one could predict the increased ICP. Sixty-eight patients were diagnosed as definite IIH and 68 healthy volunteers are included in the study who had the same sex and age. ONSD, peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were estimated by transorbital color Doppler. Multivariate linear regression was used to discover the predictors of increased ICP. ROC curve was plotted for the predictor. A statistically significant difference was found between IIH patients and controls regarding ONSD, EDV and RI. Multivariate linear regression revealed that ONSD is the only predictor of increased CSP pressure. Its cut-off value indicating high ICP was 5.7 mm on Rt and Lt eye (AUC: 0.916; 95% confidence interval 0.867–0.965; p < 0.001; 90% sensitivity, 80% specificity at Rt eye. AUC: 0.902; 95% confidence interval 0.845–0.958; p < 0.001; 91% sensitivity, 80% specificity at Lt eye).
NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism
Authors: Brosey Chris A , Shen Runze , Tainer John A 
Published: January 2025

Abstract
Mitochondrial metabolism requires the chaperoned import of disulfide-stabilized proteins via CHCHD4/MIA40 and its enigmatic interaction with oxidoreductase Apoptosis-inducing factor (AIF). By crystallizing human CHCHD4’s AIF-interaction domain with an activated AIF dimer, we uncover how NADH allosterically configures AIF to anchor CHCHD4’s β-hairpin and histidine-helix motifs to the inner mitochondrial membrane. The structure further reveals a similarity between the AIF-interaction domain and recognition sequences of CHCHD4 substrates. NMR and X-ray scattering (SAXS) solution measurements, mutational analyses, and biochemistry show that the substrate-mimicking AIF-interaction domain shields CHCHD4’s redox-sensitive active site. Disrupting this shield critically activates CHCHD4 substrate affinity and chaperone activity. Regulatory-domain sequestration by NADH-activated AIF directly stimulates chaperone binding and folding, revealing how AIF mediates CHCHD4 mitochondrial import. These results establish AIF as an integral component of the metazoan disulfide relay and point to NADH-activated dimeric AIF as an organizational import center for CHCHD4 and its substrates. Importantly, AIF regulation of CHCHD4 directly links AIF’s cellular NAD(H) sensing to CHCHD4 chaperone function, suggesting a mechanism to balance tissue-specific oxidative phosphorylation (OXPHOS) capacity with NADH availability.
Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization
Authors: Zaidi Syed A. H. , Caldwell Ruth B. , Rojas Modesto A. 
Published: January 2025

Abstract
Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme.
Impact of cellulose degradation on space charge dynamics and dielectric properties of Kraft paper impregnated with ester liquid in comparison with mineral oil
Authors: Alshehawy Abdelrahman M. , Matharage Shanika , Wang Zhongdong 
Published: January 2025

AbstractApplying environmentally friendly ester liquids in high‐voltage direct current (HVDC) converter transformers is a technological ambition that requires research on their performance under DC voltages. This paper researched ester liquid‐impregnated Kraft paper through experimentally investigating space charges and dielectric properties under HVDC fields. The study focused mainly on the influence of cellulose degradation. Hence, Kraft papers of different degree of polymerisation impregnated with fresh ester liquid and fresh mineral oil were tested, and their space charges, electric field distortion, conductivity and permittivity were evaluated. Strong correlations were found between these parameters. Electric field distortion in fresh ester liquid‐impregnated paper (ELIP) was higher than that in fresh mineral oil‐impregnated paper (MOIP) but remained almost constant with paper‐ageing. However, electric field distortion increased noticeably in MOIP with paper‐ageing and became higher than that in ELIP. Thus, electric field distortion resulted from space charges and conductivity mismatch under new and ageing conditions must be considered in designing the insulation systems of converter transformers.
Identification of construction materials in Pakistan: A comparative study of typical and green materials
Authors: Hussain Iqra , Waleed Qazi Muhammad , Khan Fakhre Alam , Ahmad Naveed , Yazdan Fazli , Ullah Zahid 
Published: January 2025

AbstractThis research article highlights the pressing demand for sustainable construction techniques in Pakistan's building sector as it significantly contributes to CO2 emissions, exacerbating environmental challenges. Unlike previous studies, this study uses a newly created life cycle assessment tool for comparing standard building methods to green alternatives, emphasizing cost and carbon impact. Green materials may require a more substantial initial investment, yet they offer significant long‐term benefits such as decreased CO2 emissions and cost savings. The study underlines the necessity of employing eco‐friendly techniques in Pakistan's building sector to mitigate the detrimental effects and enhance sustainability.
Depolarization and polarization transfer rates for the C2 (X1 Σ+g, a 3Πu) + H(2S1/2) collisions in the solar photosphere
Authors: Qutub S. , Kalugina Y. N. , Derouich M. 
Published: January 2025

Context. This paper is a continuation of a series of studies that investigated the collisional depolarization of solar molecular lines such as those of MgH, CN and C2. It is focused on the solar molecule C2, which exhibits striking scattering polarization profiles, although its intensity profiles are inconspicuous and barely visible. The current interpretation of the C2 polarization in terms of magnetic fields is incomplete because collisional data are almost completely lacking.
Aims. We accurately compute the collisional depolarization and polarization transfer rates for the C2(X1Σg+,α3Πu) by isotropic collisions with hydrogen atoms H (2S l/2). We also investigate the solar implications of our findings.
Methods. We used the package MOLPRO to obtain potential energy surfaces for the electronic states X1Σg+ and a3Πu of C2, and the code MOLSCAT to study the quantum dynamics of the C2(X1Σg+,α3Πu) + H(2S1/2) systems. We used the tensorial irreducible basis to express the resulting collisional cross sections and rates. Furthermore, sophisticated genetic programming techniques were employed to determine analytical expressions for the temperature and total molecular angular momentum dependence of these collisional rates.
Results. We obtained quantum depolarization and polarization transfer rates for the C2(X1Σg+,α3Πu) + H(2S1/2) collisions in the temperature range T = 2000−15 000 K. We also determined analytical expressions that write these rates as functions of the temperature and total molecular angular momentum. In addition, we show that isotropic collisions with neutral hydrogen can only partially depolarize the lower state of the C2 lines. This highlights that the approximation of neglecting lower-level polarization is limited in modeling the polarization of C2 lines.
Conclusions. Isotropic collisions with neutral hydrogen atoms are a fundamental ingredient for understanding C2 polarization.
Repeated injections of isovaline lead to analgesic tolerance and
cross-tolerance to salicylate but not to morphine in male mice
Authors: Moghimian Maryam , Nazari-Motlagh Reza , Alavi-Kakhki Seyed Sajjad , Ghaffari Mahdi Khorsand , Akbari Elham , Fani Masoumeh , Sadegh Mehdi , Gholami Masoumeh 
Published: January 2025

AbstractTolerance to the antinociceptive effects of opioids is a major concern. Studies
have shown that chronic use of non-steroidal anti-inflammatory (NSAIDs) causes
significant tolerance and cross-tolerance to morphine. Chronic NSAIDs use can
increase the risk of certain diseases, such as peptic ulcers, and exacerbate
others, like heart failure. Therefore, developing novel pharmacological
approaches could provide considerable benefits for chronic therapeutic
procedures. Isovaline with a chemical structure similar to glycine and GABA
induce a significant analgesic effect through GABA-B receptors. In this study,
we investigated the impact of both short-term and long-term use of isovaline on
the immediate response to pain, as well as the development of analgesic
tolerance through daily injection (i.p.) of isovaline (100 mg/kg) for 5 days in
male Balb/c mice. Additionally, on day 6, we examined the potential for
cross-tolerance between isovaline and sodium salicylate (300 mg/kg) or morphine
(5 mg/kg). The findings showed that isovaline injection resulted in a delayed
onset of analgesic effect, a lowered peak effect, and less cumulative pain
relief compared with sodium salicylate and morphine. This analgesic effect
gradually decreased over the five days of isovaline injection. When sodium
salicylate was injected into isovaline-tolerant mice, the antinociceptive effect
decreased, suggesting cross-tolerance to sodium salicylate. However, no such
tolerance was observed following morphine injection. Accordingly, it seems that
chronic isovaline may interact with the sodium salicylate analgesic pathway but
not with morphine.
US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis
Authors: David Yakira , Kakked Gaurav , Confer Bradley , Shah Ruchit , Khara Harshit , Diehl David L , Krafft Matthew Richard , Shah-Khan Sardar M , Nasr John Y , Benias Petros , Trindade Arvind , Muniraj Thiruvengadam , Aslanian Harry , Chahal Prabhleen , Rodriguez John , Adler Douglas G , Dubroff Jason , De Latour Rabi , Tzimas Demetrios , Khanna Lauren , Haber Gregory , Goodman Adam J , Hoerter Nicholas , Pandey Nishi , Bakhit Mena , Kowalski Thomas E. , Loren David , Chiang Austin , Schlachterman Alexander , Nieto Jose , Deshmukh Ameya , Ichkhanian Yervant , Khashab Mouen A. , El Halabi Maan , Kwon Richard S. , Prabhu Anoop , Hernandez-Lara Ariosto , Storm Andrew , Berzin Tyler M. , Poneros John , Sethi Amrita , Gonda Tamas A , Kushnir Vladimir , Cosgrove Natalie , Mullady Daniel , Al-Shahrani Abdullah , D'Souza Lionel , Buscaglia Jonathan , Bucobo Juan Carlos , Rolston Vineet , Kedia Prashant , Kasmin Franklin , Nagula Satish , Kumta Nikhil A , DiMaio Christopher 
Published: January 2025

AbstractEUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS.A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure.A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30–1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22–208.52, P = 0.04) and the occurrence of a LAMS-specific AE (OR 63.60, 95% CI 5.08–799.29, P <0.01) were associated with RAC. AEs occurred in 38 of 109 patients (34.9%) at any time, and in 10 of 109 (9.17%) > 30 days from the index procedure. Most long-term AEs (7 of 109; 6.42%) were LAMS-specific. No technical or clinical factors were associated with occurrence of AEs. LAMS were removed in 24 of 109 patients (22%). There was no difference in RAC or AEs whether LAMS was removed or not.EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.
WEE1 Inhibition by AZD1775 Augments Colorectal Cancer Cells
Susceptibility to VE-822-induced DNA Damage and Apoptosis
Authors: Mihanfar Ainaz , Asghari Faezeh , Majidinia Maryam 
Published: January 2025

AbstractWEE1 is a key tyrosine kinase involved in the cell cycle regulation with
potent anticancer effects in various cancer types including colorectal
cancer. Recent studies have focused on the potential of combinational
inhibition of Ataxia Telangiectasia and Rad-3-related protein (ATR) and WEE1
in increasing apoptosis in cancer cells. Therefore, this study investigates
the effects of inhibiting WEE1, by employing AZD1775, on colorectal cancer
cellsʼ susceptibility to VE-822-induced DNA damage and apoptosis.SW-480 and HT-29 cells were treated with AZD1775 and VE-822, alone and in
combination. MTT assay was used to assess cell proliferation and viability.
The mRNA levels of ATR, checkpoint kinase 1 (CHK1), WEE1, ribonucleotide
reductase (RR) catalytic subunit M1 (RRM1) and RRM2 were measured by
qRT-PCR. Cellular γ-(H2A histone family member X) H2AX levels were measured
by Western blot. Analyses were conducted using ELISA to assess
8-Oxo-2ʼ-deoxyguanosine (8-oxo-dG) levels. Lactate dehydrogenase (LDH) and
ELISA death assays were used to assess apoptosis.The SW-480 and HT-29 cells have low proliferation rate when treated with
VE-822 and AZD1775. The IC50 value for VE-822 was 1.3 μM and 1.6 μM in SW480
and HT-29, respectively. Also, this value for AZD1775 in SW480 was 140 nM
and in HT-29 was 185 nM. The expression levels of ATR, CHK1, WEE1, RRM1, and
RRM2 were significantly downregulated in both cell lines treated with
combination of VE-822 and AZD1775 (P<0.05). DNA damage markers, including
γ-H2AX and 8-oxo-dG were upregulated in these cells. Simultaneous treatment
with VE-822 and AZD177 increased apoptosis capacity of both cell lines.The inhibition of WEE1 via AZD1775 potentiated the anticancer effects of ATR
inhibitor, VE-822, in combating colorectal cancer via targeting DNA
damage.
Day before late regimen vs standard split dose of low-volume PEG-CS for early morning colonoscopy: Multicenter randomized controlled trial
Authors: Pasquale Luigi , Grande Giuseppe , Zagari Rocco Maurizio , Biancheri Paolo , Pisani Antonio , Da Massa Carrara Paola , Germanà Bastianello , Ciliberto Enrico , Cengia Gianpaolo , Lamazza Antonietta , Lorenzini Patrizia , Carati Mariavittoria V , Laterza Liboria , Pigò Flavia , Picascia Desiree , Stillitano Carmelo , Pollastro Matteo , Dal Pont Elisabetta , Maraggi Stefania , Conigliaro Rita , Galloro Giuseppe 
Published: January 2025

AbstractDespite lower patient adherence, the overnight split-dose (SD) intestinal preparation regimen is currently recommended for early morning colonoscopies. Using low-volume preparation, we compared performance of a “day before late” (DBL) regimen, with the whole preparation taken between 8.30 pm and midnight on the day before the endoscopic procedure vs the overnight SD regimen for colonoscopies scheduled between 8 am and 10 am.Patients were randomized to the DBL group (n = 162) or SD group (n = 158). The SD group took the second dose 5 hours before colonoscopy. Successful bowel cleansing, defined as an overall Boston Bowel Preparation Score ≥ 3, safety, compliance and tolerability were assessed in the two groups.The DBL regimen failed to demonstrate non-inferiority compared with the SD regimen in terms of successful bowel cleansing (DBL, 88.2 % vs SD, 98.1%, P < 0.001). Subgroup analysis on colonoscopies before 9 am showed BBPS ≥ 3 rates of 94.6% and 100% in the DBL and SD groups, respectively P = 0.126). The two regimens showed similar compliance and tolerability. Compared with SD patients (25.5%), a lower proportion of DBL patients (13.9%) reported fear of incontinence during the journey to the hospital (P = 0.01).Albeit more tolerable, the DBL regimen was less effective than the SD regimen with regard to successful bowel cleansing for colonoscopies between 8 am and 10 am. Subgroup analysis on colonoscopies scheduled before 9 am showed that the two regimens have similar efficacy, suggesting that the DBL regimen may be a valuable alternative to the SD regimen for very early morning colonoscopies.
Deconstruction at the Time of Post-Truth Politics
Authors: Pusterla Elia R.G. 
Published: January 2025

Abstract
Deconstructionist depiction of fictionality within the relationship between truth and sovereignty helps to understand how time relates to post-truth politics and to counter its proliferation within politics. The article connects the philosophical arguments of Jacques Derrida and Giorgio Agamben to explore the pervasive nature of post-truth within politics. Their differing conceptualisations of the place of time are both fundamentally rooted in the ontological problem of sovereignty, though they yield significantly different implications for post-truth politics. Derrida’s deconstruction of the temporal dimension in politics highlights the intricate relationship between the temporal and epistemological aspects inherent in the fictional narratives reinforced by sovereignty—narratives that fuel post-truth politics. This approach contrasts Agamben’s archaeological political theory, which reveals fictionality by subsuming sovereignty over time. This illuminates the epistemic challenges posed by post-truth politics and contends that deconstructionist epistemological standards are essential heuristics to counter the rise and proliferation of post-truth politics.
Convergence of Poisson point processes and of optimal transport regularization with application in variational analysis of PET reconstruction
Authors: Mauritz Marco , Wirth Benedikt 
Published: January 2025

Abstract
Poisson distributed measurements in inverse problems often stem from Poisson point processes that are observed through discretized or finite-resolution detectors, one of the most prominent examples being positron emission tomography (PET). These inverse problems are typically reconstructed via Bayesian methods. A natural question then is whether and how the reconstruction converges as the signal-to-noise ratio tends to infinity and how this convergence interacts with other parameters such as the detector size. In this article we carry out a corresponding variational analysis for the exemplary Bayesian reconstruction functional from [1,2], which considers dynamic PET imaging (i.e. the object to be reconstructed changes over time) and uses an optimal transport regularization.