bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversible Nanocomposite by Programming Amorphous Polymer Conformation Under Nanoconfinement
Authors: Chen Tiffany , Qian Yiwen , Laine Antoine , Kwon Junpyo , Liu Luofu , Pal Subhadeep , Gupta Supriya , Vargo Emma , Su Gregory M. , Ritchie Robert O. , Keten Sinan , Wang Rui , Salmeron Miquel , Xu Ting 
Published: January 2025

AbstractNanoconfinements are utilized to program how polymers entangle and disentangle as chain clusters to engineer pseudo bonds with tunable strength, multivalency, and directionality. When amorphous polymers are grafted to nanoparticles that are one magnitude larger in size than individual polymers, programming grafted chain conformations can “synthesize” high‐performance nanocomposites with moduli of ≈25GPa and a circular lifecycle without forming and/or breaking chemical bonds. These nanocomposites dissipate external stresses by disentangling and stretching grafted polymers up to ≈98% of their contour length, analogous to that of folded proteins; use both polymers and nanoparticles for load bearing; and exhibit a non‐linear dependence on composition throughout the microscopic, nanoscopic, and single‐particle levels.
Fe/Mo‐Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti‐Breast Cancer Immunity
Authors: Xiang Qinyanqiu , Yang Xue , Zhang Zhiqi , Yang Jie , Li Yingbo , Du Jiawei , Wang Jue , Fan Kai , Yuan Jiaxin , Zhang Jianqiong , Xie Jinbing , Ju Shenghong 
Published: January 2025

AbstractImmunogenic cell death (ICD)‐mediated immunization strategies have great potential against breast cancer. However, traditional strategies neglect the increase in the immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that the adenosine A2A receptor (A2AR) is significantly expressed in breast cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo‐based lipid peroxidation (LPO) nanoamplifiers and A2AR blockade is reported to maximize ICD‐mediated anti‐tumor immunity. This LPO nanoamplifier causes LPO explosion by the Fe (II)‐mediated Fenton reaction and Mo(V)‐mediated Russell mechanism. Subsequently, it elicits the ICD magnification of tumor cells by inducing multiple regulated cell death patterns of ferroptosis, apoptosis, and necroptosis. Additionally, the A2AR antagonist (SCH58261), an immunometabolic checkpoint blocker, is found to relieve ADO‐related immunosuppression, amplify anti‐tumor immunological effects, and elicit immune memory responses. This robust anti‐tumor immunity is observed in primary, distant, pulmonary metastatic, and recurrent tumors. This study provides a novel strategy for optimizing ICD‐mediated immunotherapy and highlights the benefits of combining LPO explosion with A2AR blockade to enhance breast cancer immunotherapy.
Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation
Authors: Kim Eunu , Lee Geon Min , Lee Haeshin 
Published: January 2025

AbstractHair loss affects millions globally, creating a demand for safer, more effective treatments. Traditional treatments like minoxidil often have limited efficacy and side effects. This study explores tannic acid, a polyphenol, as a promising alternative, serving as a multifaceted adhesion mediator that binds to keratin on the hair surface and serves as a reservoir for functional molecules‐salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL)‐collectively termed SCANDAL. Tannic acid forms a stable coating on hair through hydrogen bonding, while its unbound phenolic sites sequester SCANDAL molecules, enabling their controlled release upon exposure to moisture. This gradual release delivers active molecules directly to hair follicles, enhancing hair health and mitigating hair loss. In a seven‐day study with 12 human participants, an average reduction of 56.2 ± 18.2% in the number of shed hairs is observed compared to their baseline counts. The presence of tannic acid on the hair surface is confirmed via X‐ray photoelectron spectroscopy (XPS), and the formation of tannic acid/SCANDAL complexes is visualized using transmission electron microscopy (TEM). This approach demonstrates that hair keratin surfaces can serve as large‐area platforms for controlled release of therapeutic agents, addressing various challenges in hair and scalp health.
Enhancing Prediction Performance and Generalizing for Transverse Behavior of Unidirectional Composites via Strategic Input Feature Augmentation
Authors: Park Minwoo , Jung Jiyoung , Moon Hyeonbin , Park Donggeun , Go Myeong‐Seok , Noh Hong‐Kyun , Lim Jae Hyuk , Ryu Seunghwa 
Published: January 2025

AbstractThis study proposes an efficient method for analyzing complex fracture patterns in the cross‐sections of unidirectional (UD) composites, influenced by the volume fraction (VF) and fiber arrangement, and for predicting the corresponding transverse mechanical responses. Traditional finite element (FE) analysis incurs high computational costs when evaluating responses for every configuration. To address this, deep learning (DL), particularly convolutional neural networks (CNNs), have been applied, but these approaches have typically focused on limited VF spaces, leading to large data requirements and reduced prediction accuracy for new configurations. In this research, a novel DL approach is introduced that can be effectively extended to broader VF spaces by integrating low‐cost, physically insightful auxiliary features as multi‐modal inputs. Specifically, the Mori–Tanaka (MT) feature and stress concentration factor (SCF) are selected as auxiliary inputs and incorporated them into the conventional CNN model for comparative analysis. The results showed that the model incorporating the MT feature significantly improved extrapolation performance in unseen VF spaces while maintaining robust predictive performance as the training dataset size increased. In contrast, the SCF feature does not demonstrate similar benefits. These findings illustrate that integrating advanced features like the MT feature into the DL model can offer more effective and versatile solutions for predicting material properties.
Direct Observation of Anisotropic Coulomb Interaction in a Topological Nodal Line Semimetal
Authors: Kim Hyo Won , Jung Junseo , Lee Gahee , Park Taesu , Jang Won‐Jun , Kim Hoil , Kim Jun Sung , Shim Ji Hoon , Yang Bohm‐Jung , Jeon Sangjun 
Published: January 2025

AbstractThe fundamental characteristics of collective interactions in topological band structures can be revealed by the exploration of charge screening in topological materials. In particular, distinct anisotropic screening behaviors are predicted to occur in Dirac nodal line semimetals (DNLSMs) due to their peculiar anisotropic low‐energy dispersion. Despite the recent extensive theoretical research, experimental observations of exotic charge screening in DNLSMs remain elusive, which is partly attributed to the coexisting trivial bands near the Fermi energy. This study reports the first direct observation of highly anisotropic charge‐screening behavior in the DNLSM SrAs3. Through atomically resolved conductance measurements, a highly anisotropic charge‐screening pattern around charged impurities on a surface is demonstrated. Moreover, the combination of model studies and first‐principles calculations reveals the unique nature of the screening anisotropy in DNLSMs. The results of this study are expected to pave the way for understanding the profound collective behavior of interacting low‐energy fermions in topological materials.
Tape‐Assisted Residual Layer‐Free One‐Step Nanoimprinting of High‐Index Hybrid Polymer for Optical Loss‐Suppressed Metasurfaces
Authors: Park Yujin , Kim Joohoon , Yang Younghwan , Oh Dong Kyo , Kang Hyunjung , Kim Hongyoon , Rho Junsuk 
Published: January 2025

AbstractThe commercialization of metasurfaces is crucial for real‐world applications such as wearable sensors, pigment‐free color pixels, and augmented and virtual reality devices. Nanoparticle‐embedded resin‐based nanoimprint lithography (PER‐NIL) has shown itself to be a low‐cost, high‐throughput manufacturing method enabling the replication of high‐index nanostructures. It has been extensively integrated into the fabrication of hologram metasurfaces, metalenses, and sensors due to its procedural simplicity. Most research on PER‐NIL has been limited to exploring appropriate materials to enhance the efficiency of imprinted metasurfaces, but the intrinsic issue of PER‐NIL lies in the high‐index residual layer remaining on the substrate. This high‐index residual layer generates undesired noise, limiting the efficiency and functionality of imprinted metasurfaces. Despite the need for the removal of the residual layer, it has never been experimentally achieved owing to the different etching rates between the nanoparticles and resin. Here, a new methodology named tape‐assisted PER‐NIL is proposed, achieving one‐step removal of the residual layer using a tape. This novel method enables the replication of residual layer‐free, high‐index metasurfaces. As a result, imprinted residual layer‐free metasurfaces prove their potential in high‐purity dielectric structural colorations by achieving a sharp reflectance peak unattainable with conventional NIL, and in vivid hologram metasurfaces by covering a full 2π phase without unwanted scattering.
Posttranscriptional Control of Neural Progenitors Temporal Dynamics During Neocortical Development by Syncrip
Authors: Wu Jiarui , Yu Haoyang , Dou Xinyi , Yin Bin , Hou Lin , Xue Yuanchao , Qiang Boqin , Shu Pengcheng , Peng Xiaozhong 
Published: January 2025

AbstractThe development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons, remain unclear. Here, the hnRNP family member Syncrip (hnRNP Q) is identified as a key modulator of superficial neuronal differentiation in neocortical neurogenesis. Syncrip knockout in RGCs disrupts differentiation and abnormal neuronal localization, ultimately resulting in superficial cortical layer defects as well as learning and memory impairments in mice. Single‐cell RNA sequencing analysis demonstrated that the knockout of Syncrip disrupts the late‐stage neurogenesis, stalling transcriptional progression in RGCs. Mechanistically, Syncrip maintains the transcription of temporal process‐related transcription factors by recruiting stabilization complexes through phase separation, crucially regulating the Notch signaling pathway that determines the fate of RGCs. Furthermore, pathogenic human mutations in Syncrip weaken its phase‐separation capability, failing to form stable complexes normally. Thus, Syncrip acts as a mediator of posttranscriptional regulatory mechanisms, governing the fate progression of RGCs and the advancement of intrinsic temporal programs. This study establishes an intracellular mechanism for posttranscriptional regulation of progressive fate determination in cortical neurogenesis.
Cellular Core/Sheath Filaments with Thermoresponsive Vacuum Cavities for Prolonged Passive Temperature‐Adaptive Thermoregulation
Authors: Sui Jiayi , Jiang Shoukun , Peng Jinhao , Kang Zhanxiao , Fan Jintu 
Published: January 2025

AbstractActing as the interface between the human body and its environment, clothing is indispensable in human thermoregulation and even survival under extreme environmental conditions. Development of clothing textiles with prolonged passive temperature‐adaptive thermoregulation without external energy consumption is much needed for protection from thermal stress and energy saving, but very challenging. Here, a temperature‐adaptive thermoregulation filament (TATF) consisting of thermoresponsive vacuum cavities formed by the temperature‐responsive volume change of the material confined in the cellular cores of the filament is proposed. Using a droplet‐based microfluidic system, the cellular core/sheath filament using octadecane (OD) as a temperature‐responsive volume‐changing material to form droplet cellular cores within the thermoplastic polyurethane (TPU) sheath is fabricated. It is found that the fabric made of TATF has a remarkable temperature adaptive thermal conductivity, which increases by 83% as the mean fabric temperature increases from 20 °C to 35 °C, due to the volume change of vacuum cavities in the cellular cores of the filament in response to temperature. TATF fabrics have no problem associated with undesirable appearance changes or leakage of encapsulated molten materials as some existing thermoregulatory textiles do, and can therefore have wide applications in functional clothing for prolonged passive personal thermal management.
Tailoring Super‐Performed Chemo‐Sensor via Simulation‐Modeling and MEMS‐Screening
Authors: Xu Wei , Zhang Wukun , Shen Zhengqi , Xu Wenxing , Zhao Jianhao , Li Huizi , He Qingguo , Fu Yanyan , Cheng Jiangong 
Published: January 2025

AbstractChemo‐sensor designing involves a time‐consuming trial‐and‐error screening process, which commonly cannot lead to optimal S4R features (Sensitivity, Selectivity, Speed, Stability, and Reversibility). Due to strong path dependence on reported groups/mechanisms, conventional chemo‐sensors often fail to meet critical application demands, especially in achieving high reversibility without compromising other features. Here, a three‐step screen and design strategy is developed for gaining customized chemo‐sensors, through Structure modeling; MEMS (Micro Electro Mechanical Systems) analysis, and Performance verification. With such a strategy, the coordination hanging anion mechanism is screened out for reversible nerve agent detection and shows reversible emission enhancement by 25.8 times with DCP, ultrasensitive vapor phase detection (5.7 ppb), and rapid response(10 s) and recovery speed (20 s). Such tailored designing strategy for new organic chemo‐sensors will probably play an important role in developing high‐performance sensing system in the future.
Step by step: Anti‐Asian discrimination and bystander intervention
Authors: Woo Bongki , Roth Benjamin 
Published: January 2025

AbstractCombating the recent surge of anti‐Asian racism requires a collective effort that includes the willingness of nontarget bystanders to intervene, but little is known about the circumstances under which they are willing to do so. The present qualitative study explores why non‐Asian bystanders decide to intervene when they witness anti‐Asian racism, and why, under other circumstances, they choose not to. Twenty semi‐structured interviews were conducted with non‐Asian college students who witnessed anti‐Asian discrimination. Guided by the five‐stage sequential decision‐making framework of bystander intervention, we analyzed intervention as a series of stages: seeing the event, recognizing it as worthy of intervention, determining one's responsibility for acting, deciding how to act, and, finally, executing on that plan. The respondents recounted a diverse range of situations and factors in each stage that impacted why they intervened or not. Our findings suggest that the act of intervening increases the bystander's confidence and desire to intervene again in the future. Given the complexity of the bystander decision chain and the compressed timeframe in which it often occurs, we conclude that training on bystander antiracist intervention might benefit from being structured according to the multi‐stage model.
Defluorinative Hydroxylation Promoted by Silica to Access Optically Pure Hexahydrofuranocarbazole via [4+2] Addition Reaction
Authors: Prasad Madavi S. , Bedanta Thoudam , Saha Souvik , Kumar Jha Aman , Bharani Sankar , Chandrasekhar Ponnada 
Published: January 2025

AbstractCrafting an efficient strategy for the synthesis of biologically active and functionally rich hexahydrofuranocarbazole is a highly desirable but demanding pursuit. This research elucidates a groundbreaking strategy involving an unanticipated defluorinative hydroxylation reaction facilitated by silica gel, yielding highly enantio‐ and diastereoselective hexahydrofuranocarbazole frameworks. This method results in the formation of five consecutive chiral centers, including three quaternary stereocenters and an all‐carbon spiro center, via an aminocatalytic asymmetric remote [4+2] addition process. The developed methodology allows for the construction of a diverse array of products (24 examples, up to >99 % ee and 17 : 1 dr), reflecting its notable substrate scope. Furthermore, we demonstrate the feasibility of gram‐scale synthesis and control experiments that underscore the methodological advancements and provide insights into the underlying mechanism.
Multicomponent Polymerization toward Poly(BODIPY‐sulfonamide)s as Unique SO2 Generators for Sonodynamic and Gas Combination Therapy
Authors: Liu Shuxin , Li Juan , Wang Aiguo , Ng Dennis K. P. , Zheng Nan 
Published: January 2025

AbstractIn this work, a multicomponent polymerization (MCP) approach involving bipyrroles, sulfonyl azides, and diynes was developed to afford a library of poly(bipyrrole‐sulfonylimide)s (PPSIs) in high yields and molecular weights, which were further modified to form unique sulfur dioxide (SO2) generators. Bipyrroles served as carbon‐based nucleophiles to undergo Cu‐catalyzed C−C coupling during the MCP. Upon post‐MCP modification by transforming the bipyrrole unit to boron dipyrromethene (BODIPY) and the sulfonylimide moiety to sulfonamide, poly(BODIPY‐sulfonamide)s (PBSAs) were obtained as potent anticancer therapeutic agents. This study disclosed the decomposition and SO2‐releasing ability of PBSAs under ultrasound (US) irradiation. Furthermore, one of these polymers having a reactive oxygen species‐cleavable thioketal linker was modified with triethylene glycol chains to give PBSA‐EG, which was further studied for in vitro and in vivo US‐induced anti‐cancer therapy. Upon tail veil administration of PBSA‐EG nanoparticles into tumor‐bearing mice followed by US irradiation, remarkable tumor suppression was observed. This study demonstrates that the innovative and efficient MCP method can construct polymers bearing the BODIPY‐sulfonamide moieties, which show a great potential as safe and potent materials for combined gas and sonodynamic therapy against cancer.
Design of Cell‐Penetrating Domain Antibodies via a Genetically Encoded β‐Lactam Amino Acid
Authors: Rabb Johnathan D. , Kruse Lucas E. , Lin Qing 
Published: January 2025

AbstractDomain antibodies such as monobodies provide an attractive immunoglobin fold for evolving high‐affinity protein binders targeting the intracellular proteins implicated in cell signalling. However, it remains a challenge to endow cell permeability to these small and versatile protein binders. Here, we report a streamlined approach combining orthogonal crosslinking afforded by a genetically encoded β‐lactam‐lysine (BeLaK) and genetic supercharging to generate cell‐penetrating monobodies. When introduced to the N‐terminal β‐strand of a series of supercharged monobodies, BeLaK enabled efficient inter‐strand crosslinking with the neighbouring lysine. Compared to its non‐crosslinked counterpart, a BeLaK‐crosslinked, +18‐charged monobody exhibited enhanced thermostability and greater cellular uptake at 40 nM. Moreover, this structurally rigidified, supercharged monobody inhibited ERK1/2 phosphorylation in KYSE‐520 esophageal cancer cell line at sub‐micromolar concentration, indicating significant endosomal escape after endocytosis. Together, the discovery of this BeLaK‐encoded, rigidified immunoglobin fold should facilitate the design of cell‐penetrating monobodies targeting intracellular signalling proteins.
Modular Photoswitchable Molecular Glues for Chemo‐Optogenetic Control of Protein Function in Living Cells
Authors: Zhang Jun , Herzog Laura K. , Corkery Dale P. , Lin Tzu‐Chen , Klewer Laura , Chen Xi , Xin Xiaoyi , Li Yaozong , Wu Yao‐Wen 
Published: January 2025

AbstractOptogenetic systems using photosensitive proteins and chemically induced dimerization/proximity (CID/CIP) approaches enabled by chemical dimerizers (also termed molecular glues), are powerful tools to elucidate the dynamics of biological systems and to dissect complex biological regulatory networks. Here, we report a versatile chemo‐optogenetic system using modular, photoswitchable molecular glues (sMGs) that can undergo repeated cycles of optical control to switch protein function on and off. We use molecular dynamics (MD) simulations to rationally design the sMGs and further expand their scope by incorporating different photoswitches, resulting in sMGs with customizable properties. We demonstrate that this system can be used to reversibly control protein localization, organelle positioning, protein‐fragment complementation as well as posttranslational protein levels by light with high spatiotemporal precision. This system enables sophisticated optical manipulation of cellular processes and thus opens up a new avenue for chemo‐optogenetics.
Unveiling Chirality in MoS2 Nanosheets: A Breakthrough in Phase Engineering for Enhanced Chiroptical Properties
Authors: Branzi Lorenzo , Fitzsimmons Lucy , Chunin Igor , Shvets Igor , Gun'ko Yurii K. 
Published: January 2025

AbstractThe development of new synthetic strategies to introduce and control chirality in inorganic nanostructures has been highly stimulated by the broad spectrum of potential applications of these exiting nanomaterials. Molybdenum disulfide is among the most investigated transition metal dichalcogenides due to its promising properties for applications that spread from optoelectronic to spintronic. Herein, we report a new two‐step approach for the production of chiroptically active semiconductor 2H MoS2 nanosheets with chiral morphology based on the manipulation of their crystallographic structure. In the first step, metastable metallic 1T MoS2 nanosheets with chiral morphology were produced via hydrothermal synthesis. Then, thermal annealing was used to progressively tune the conversion of the metallic 1T phase into the thermodynamically stable semiconductor 2H phase while preserving the nanocrystals’ chiral morphology. Our detailed study covers the evolution of the chiroptical properties of the material during the crystallographic phase transition, revealing critical insights into the formation of chiroptically active excitonic transitions. This study represents a unique approach to the production of high‐quality chiral nanomaterials by exploiting phase engineering, and paves the way for the development of new synthetic methods to further expand the range and properties of chiral nanomaterials.