bluuebunny/crossref_metadata_2025_split huggingface dataset:
Front-end design prototyping strategies during remote stakeholder engagement
Authors: Moses Nick D. , Wojciechowski Lauren R. , Daly Shanna R. , Sienko Kathleen H. 
Published: August 2023

AbstractEngineers must engage project stakeholders effectively if stakeholder needs are to be met, and prototypes are key tools for communicating design form and function. Quality stakeholder engagement in the front end of design processes, in particular, is critical in the success or failure of design projects. As remote stakeholder engagement has become increasingly common as industry trends toward distributed design, there is a need to develop the theory and practices behind effective remote design processes, which have not yet been as well-studied as in-person design. This study explored the prototyping strategies for remote stakeholder engagement during front-end design used by 10 engineering practitioners and 10 senior engineering students through semi-structured interviews. Prototyping strategies were found to overlap with many of the strategies described by prior literature that are not specific to remote engagement modes, though several of these strategies were adapted to the remote context, and three emergent strategies for prototyping in remote engagements were identified. Designers’ perceptions of remote versus in-person prototyping strategies for stakeholder engagement in front-end design, including perceived advantages and limitations, were also explored, and recommendations for educators to better prepare engineering students for hybrid and remote work are provided.
Tiny insects, big troubles: a review of BOLD's COI database for Thysanoptera (Insecta)
Authors: Lindner Mariana F. , Gonçalves Leonardo T. , Bianchi Filipe M. , Ferrari Augusto , Cavalleri Adriano 
Published: August 2023

AbstractDNA Barcoding is an important tool for disciplines such as taxonomy, phylogenetics and phylogeography, with Barcode of Life Data System (BOLD) being the largest database of partial cytochromecoxidase subunit I (COI) sequences. We provide the first extensive revision of the information available in this database for the insect order Thysanoptera, to assess: how many COI sequences are available; how representative these sequences are for the order; and the current potential of BOLD as a reference library for specimen identification and species delimitation. The COI database at BOLD currently represents only about 5% of the over 6400 valid thrips species, with a heavy bias towards a few species of economic importance. Clear Barcode gaps were observed for 24 out of 33 genera evaluated, but many outliers were also observed. We suggest that the COI sequences available in BOLD as a reference would not allow for accurate identifications in about 30% of Thysanoptera species in this database, which rises to 40% of taxa within Thripidae, the most sampled family within the order. Thus, we call for caution and a critical evaluation in using BOLD as a reference library for thrips Barcodes, and future efforts should focus on improving the data quality of this database.
The relationship between feed efficiency and behaviour differs between lactating Holstein and Jersey cows
Authors: Thorup Vivi M. , Munksgaard Lene , Terré Marta , Henriksen Julie C. S. , Weisbjerg Martin R. , Løvendahl Peter 
Published: August 2023

AbstractIn dairy production, high feed efficiency (FE) is important to reduce feed costs and negative impacts of milk production on the climate and environment, yet little is known about the relationship between FE, eating behaviour and activity. This research communication describes how cows differing in FE, expressed as daily energy corrected milk production per unit of feed intake, differed in eating behaviour and activity. We used data from a study of 253 lactations obtained from 97 Holstein and 91 Jersey cows milked in an automatic milking system. Automated feed troughs recorded feed intake behaviour and cows wore a sensor that recorded activity from 5 to 200 d in milk (DIM). We used a mixed linear model to estimate random solutions for individual cows for traits of steps, lying and eating behaviour and calculated their correlation with FE during four periods (5–35, 36–75, 76–120 and 121–200 DIM). Separate analyses were performed for each breed and period. We found that individual level correlations between FE and behaviour traits were stronger in Jersey than in Holstein cows. Eating rate correlated weakly negatively to FE in Holstein cows and more strongly so in Jersey cows, such that efficient Jerseys were slower eaters. The physical activity of Jersey cows was weakly and negatively correlated to FE, but this was not the case in Holstein cows. We conclude that eating rate was consistently negatively associated with FE throughout lactation for Jersey cows, but not for Holstein cows.
Genomic advances in the study of the mosquito vector during avian malaria infection
Authors: Hernandez-Caballero Irene , Hellgren Olof , Garcia-Longoria Batanete Luz 
Published: August 2023

AbstractInvertebrate host–parasite associations are one of the keystones in order to understand vector-borne diseases. The study of these specific interactions provides information not only about how the vector is affected by the parasite at the gene-expression level, but might also reveal mosquito strategies for blocking the transmission of the parasites. A very well-known vector for human malaria is Anopheles gambiae. This mosquito species has been the main focus for genomics studies determining essential key genes and pathways over the course of a malaria infection. However, to-date there is an important knowledge gap concerning other non-mammophilic mosquito species, for example some species from the Culex genera which may transmit avian malaria but also zoonotic pathogens such as West Nile virus. From an evolutionary perspective, these 2 mosquito genera diverged 170 million years ago, hence allowing studies in both species determining evolutionary conserved genes essential during malaria infections, which in turn might help to find key genes for blocking malaria cycle inside the mosquito. Here, we extensively review the current knowledge on key genes and pathways expressed in Anopheles over the course of malaria infections and highlight the importance of conducting genomic investigations for detecting pathways in Culex mosquitoes linked to infection of avian malaria. By pooling this information, we underline the need to increase genomic studies in mosquito–parasite associations, such as the one in Culex–Plasmodium, that can provide a better understanding of the infection dynamics in wildlife and reduce the negative impact on ecosystems.
Distribution of large lungworms (Nematoda: Dictyocaulidae) in free-roaming populations of red deer Cervus elaphus (L.) with the description of Dictyocaulus skrjabini n. sp.
Authors: Pyziel Anna Maria , Laskowski Zdzisław , Klich Daniel , Demiaszkiewicz Aleksander Wiaczesław , Kaczor Stanisław , Merta Dorota , Kobielski Janusz , Nowakowska Julita , Anusz Krzysztof , Höglund Johan 
Published: August 2023

AbstractLungworms of the genus Dictyocaulus are causative agents of parasitic bronchitis in domestic and wild ungulates. This study investigates the distribution, morphology and genetic diversity of D. cervi and a new lungworm species, Dictyocaulus skrjabini n. sp. infecting red deer Cervus elaphus, fallow deer Dama dama and moose Alces alces in Poland and Sweden. The study was conducted on 167 red deer from Poland and on the DNA of lungworms derived from 7 fallow deer, 4 red deer and 2 moose collected in Sweden. The prevalence of D. cervi and D. skrjabini n. sp. in dissected red deer in Poland was 31.1% and 7.2%, respectively. Moreover, D. skrjabini n. sp. was confirmed molecularly in 7 isolates of fallow deer lungworms and 1 isolate of red deer lungworms from Sweden. Dictyocaulus skrjabini n. sp. was established based on combination of their distinct molecular and morphological features; these included the length of cephalic vesicle, buccal capsule (BC), buccal capsule wall (BCW), distance from anterior extremity to the nerve ring, the width of head, oesophagus, cephalic vesicle, BC and BCW, as well as the dimensions of reproductive organs of male and female. Additionally, molecular analyses revealed 0.9% nucleotide sequence divergence for 1,605 bp SSU rDNA, and 16.5–17.3% nucleotide sequence divergence for 642 bp mitochondrial cytB between D. skrjabini n. sp. and D. cervi, respectively, and 18.7–19% between D. skrjabini n. sp. and D. eckerti, which translates into 18.2–18.7% amino acid sequence divergence between D. skrjabini n. sp. and both lungworms.
Adam Smith revisited: the relationship between the English woollen manufacture and the availability of coal before the use of steam power
Authors: Sugden Keith , Keibek Sebastian , Wells James , Shaw-Taylor Leigh 
Published: August 2023

AbstractThe timing of textile de-industrialisation in eastern, southern, and western England and the concomitant shift of the woollen manufacture to the West Riding of Yorkshire is examined in temporal detail. The study shows that the manufacture was moving to settlements with cheap coal, low cost of living and running water as early as the sixteenth century. These settlements became key woollen manufacture centres and remained so until the nineteenth century. The industry was located on the West Riding of Yorkshire coal field long before the industrial revolution and the demand for coal to generate steam power.
Transdiagnostic indicators predict developmental changes in cognitive control resting-state networks
Authors: Picci Giorgia , Petro Nathan M. , Son Jake J. , Agcaoglu Oktay , Eastman Jacob A. , Wang Yu-Ping , Stephen Julia M. , Calhoun Vince D. , Taylor Brittany K. , Wilson Tony W. 
Published: August 2023

AbstractOver the past decade, transdiagnostic indicators in relation to neurobiological processes have provided extensive insight into youth’s risk for psychopathology. During development, exposure to childhood trauma and dysregulation (i.e., so-called AAA symptomology: anxiety, aggression, and attention problems) puts individuals at a disproportionate risk for developing psychopathology and altered network-level neural functioning. Evidence for the latter has emerged from resting-state fMRI studies linking mental health symptoms and aberrations in functional networks (e.g., cognitive control (CCN), default mode networks (DMN)) in youth, although few of these investigations have used longitudinal designs. Herein, we leveraged a three-year longitudinal study to identify whether traumatic exposures and concomitant dysregulation trigger changes in the developmental trajectories of resting-state functional networks involved in cognitive control (N = 190; 91 females; time 1 Mage = 11.81). Findings from latent growth curve analyses revealed that greater trauma exposure predicted increasing connectivity between the CCN and DMN across time. Greater levels of dysregulation predicted reductions in within-network connectivity in the CCN. These findings presented in typically developing youth corroborate connectivity patterns reported in clinical populations, suggesting there is predictive utility in using transdiagnostic indicators to forecast alterations in resting-state networks implicated in psychopathology.
Out of the blue: inflammatory myofibroblastic tumour identified during repair of tetralogy of Fallot with absent pulmonary valve
Authors: McKinney Lauren M. , Escalera Robert B. , Downs Emily A. 
Published: August 2023

AbstractInflammatory myofibroblastic tumour of the heart is an exceedingly rare benign neoplasm. While benign, without prompt management its impact can be devastating. Tetralogy of Fallot with absent pulmonary valve is a rare form of CHD. We present the first documented case of inflammatory myofibroblastic tumour of the heart in the presence of tetralogy of Fallot with absent pulmonary valve.
Evangelical attitudes toward Syrian refugees: are evangelicals distinctive in their opposition to Syrian refugees to the United States?
Authors: Roy Oindrila 
Published: August 2023

AbstractThis study analyzes a potential source of immigration policy by comparing attitudes toward Syrian refugees across different religious traditions in the United States. The analysis focuses on the puzzling case of evangelical public opinion, where the views of lay evangelicals showed a contrast with the pro-refugee stance of the church leadership. The current analysis examines the sources of evangelical public opinion by scrutinizing the mediating effects of Muslim stereotypes. The findings from a series of regression analyses using the ANES dataset (2016) suggest that while evangelicals are not distinctive in their opposition to Syrian refugees, they are unique in holding significantly high levels of Muslim stereotypes, which makes them more opposed to allowing refugees from Syria. Additionally, interesting differences in attitudes emerge within the evangelical community, thereby cautioning against generalizing the divide between church leadership and laity. Finally, measures of religiosity demonstrate significant effects on attitudes across religious traditions.
Long‐Term Changes in Concentration and Yield of Riverine Dissolved Silicon From the Poles to the Tropics
Authors: Jankowski Kathi Jo , Johnson Keira , Sethna Lienne , Julian Paul , Wymore Adam S. , Shogren Arial J. , Thomas Patrick K. , Sullivan Pamela L. , McKnight Diane M. , McDowell William H. , Heindel Ruth , Jones Jeremy B. , Wollheim Wilfred , Abbott Benjamin , Deegan Linda , Carey Joanna C. 
Published: August 2023

AbstractRiverine exports of silicon (Si) influence global carbon cycling through the growth of marine diatoms, which account for ∼25% of global primary production. Climate change will likely alter river Si exports in biome‐specific ways due to interacting shifts in chemical weathering rates, hydrologic connectivity, and metabolic processes in aquatic and terrestrial systems. Nonetheless, factors driving long‐term changes in Si exports remain unexplored at local, regional, and global scales. We evaluated how concentrations and yields of dissolved Si (DSi) changed over the last several decades of rapid climate warming using long‐term data sets from 60 rivers and streams spanning the globe (e.g., Antarctic, tropical, temperate, boreal, alpine, Arctic systems). We show that widespread changes in river DSi concentration and yield have occurred, with the most substantial shifts occurring in alpine and polar regions. The magnitude and direction of trends varied within and among biomes, were most strongly associated with differences in land cover, and were often independent of changes in river discharge. These findings indicate that there are likely diverse mechanisms driving change in river Si biogeochemistry that span the land‐water interface, which may include glacial melt, changes in terrestrial vegetation, and river productivity. Finally, trends were often stronger in months outside of the growing season, particularly in temperate and boreal systems, demonstrating a potentially important role of shifting seasonality for the flux of Si from rivers. Our results have implications for the timing and magnitude of silica processing in rivers and its delivery to global oceans.
Retrieval of Monsoon Landslide Timings With Sentinel‐1 Reveals the Effects of Earthquakes and Extreme Rainfall
Authors: Burrows K. , Marc O. , Andermann C. 
Published: August 2023

AbstractMonsoon rainfall triggers hundreds of landslides across Nepal every year, causing significant hazard and mass wasting. Annual inventories of these landslides have been mapped using multi‐spectral satellite images, but these images are obscured by cloud cover during the monsoon, making it impossible to use them to constrain landslide timing. We employ recently developed techniques to derive individual timings from Sentinel‐1 for 579 landslides in 2015, 2017, 2018, and 2019 in Nepal. We use this new timing information alongside satellite rainfall data to identify spatio‐temporal clusters of landslides and associate these with periods of particularly intense rainfall. We also observed that during the 2015 monsoon, many landslides failed earlier and in dryer conditions than in 2017–2019. We use physical models to demonstrate how this requires a temporary loss of hillslope strength following the Mw 7.8 Gorkha Earthquake sequence and suggest a modeled cohesion loss in the range 1–3 kPa.
Transient Deformation Excited by the 2021 M7.4 Maduo (China) Earthquake: Evidence of a Deep Shear Zone
Authors: Jin Zeyu , Fialko Yuri , Yang Hongfeng , Li Yu 
Published: August 2023

AbstractWe use Sentinel‐1 and ALOS‐2 Interferometric Synthetic Aperture Radar (InSAR), and Global Navigation Satellite System (GNSS) data to investigate the mechanisms of coseismic and postseismic deformation due to the 2021 M7.4 Maduo (China) earthquake. We present a refined coseismic slip model constrained by the rupture trace and precisely located aftershocks. The InSAR time series corrected for the atmospheric and decorrelation noise reveal postseismic line of sight displacements up to ∼0.1 m. The displacements are discontinuous along the fault trace, indicating shallow afterslip and velocity‐strengthening friction in the top 2–3 km of the upper crust. The magnitude of shallow afterslip is however insufficient to compensate for the coseismic slip deficit, implying substantial off‐fault yielding. The observed surface deformation does not exhibit obvious features that could be attributed to poroelastic effects. We developed a fully coupled model that accounts for both stress‐driven creep on a deep localized shear zone and viscoelastic relaxation in the bulk of the lower crust. The mid‐ to near‐field data can be reasonably well explained by deep afterslip and/or non‐Maxwellian visco‐elasticity. Our results suggest a power‐law stress exponent of ∼4–4.5 assuming a power‐law rheology, and transient and steady‐state viscosities of 1018 and 1019 Pa s, respectively, assuming a bi‐viscous (Burgers) rheology. However, a good fit to the GNSS data cannot be achieved assuming the bulk viscoelastic relaxation alone, and requires a contribution of deep afterlip and/or a localized shear zone extending through much of the lower crust.
PPP at Low Latitudes With Ionospheric Model Exclusively Based on Single Frequency GNSS Measurements
Authors: Christovam Ana L. , Prol Fabricio S. , Jerez Gabriel O. , Hernández‐Pajares Manuel , Camargo Paulo O. 
Published: August 2023

AbstractSingle frequency users of the Global Navigation Satellite System (GNSS) should correct the ionospheric delay to obtain positioning solutions. A valuable source of ionospheric delay corrections is the global ionospheric models (GIMs) of Vertical Total Electron Content. The accuracy of GIMs is therefore important to improve the positioning accuracy. One of the main issues that affects the GIM performance, especially at low latitude regions, is the high sensitivity of the global positioning system (GPS) L2 frequency to ionospheric scintillation. As an attempt to overcome this issue, in this work, we study the capabilities of using only GPS L1 frequency to compute ionospheric corrections in form of regional ionospheric maps. The performance of the new ionospheric model is evaluated by means of single frequency precise point positioning, comparing the positioning results against the correction using dual‐frequency GPS signals, as well as compared to the corrections provided by GIMs produced by the international GNSS service. As a result, the positioning performance using single frequency model presented similar accuracy to the dual frequency models and, at the same time, provided less observations affected by ionospheric scintillations. These results demonstrate the feasibility of using single frequency GNSS data to develop ionospheric models and to improve the positioning over low latitudes.
Anti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib enhances tumor progression in a transgenic mouse model of ß-cell carcinogenesis
Authors: Egidi Maren Juliane , Krug Sebastian , Haybaeck Johannes , Michl Patrick , Griesmann Heidi 
Published: August 2023

AbstractBackgroundPancreatic neuroendocrine tumors (PNETs) represent a distinct hypervascularized tumor entity, often diagnosed at metastatic stage. Therapeutic efficacy of anti-angiogenic multi-kinase inhibitors is frequently limited by primary or acquired resistance in vivo. This study aimed to characterize the molecular mode of action as well as resistance mechanisms to the anti-angiogenic multi-tyrosine kinase inhibitor (TKI) Regorafenib in vitro and in vivo.MethodsIn vitro, human and murine pancreatic neuroendocrine cell lines were comparatively treated with Regorafenib and other TKIs clinically used in PNETs. Effects on cell viability and proliferation were analyzed. In vivo, transgenic RIP1Tag2 mice were treated with Regorafenib at two different time periods during carcinogenesis and its impact on angiogenesis and tumor progression was evaluated.ResultsCompared to the established TKI therapies with Sunitinib and Everolimus, Regorafenib showed the strongest effects on cell viability and proliferation in vitro, but was unable to induce apoptosis. Unexpectedly and in contrast to these in vitro findings, Regorafenib enhanced proliferation during early tumor development in RIP1Tag2 mice and had no significant effect in late tumor progression. In addition, invasiveness was increased at both time points. Mechanistically, we could identify an upregulation of the pro-survival protein Bcl-2, the induction of the COX2-PGE2-pathway as well as the infiltration of CSF1R positive immune cells into the tumors as potential resistance mechanisms following Regorafenib treatment.DiscussionOur data identify important tumor cell-autonomous and stroma-dependent mechanisms of resistance to antiangiogenic therapies.
Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models
Authors: Dixon Angela , Shim Myoung Sup , Nettesheim April , Coyne Aislyn , Su Chien-Chia , Gong Haiyan , Liton Paloma B. 
Published: August 2023

AbstractGlaucoma is a group of diseases that leads to chronic degeneration of retinal ganglion cell (RGC) axons and progressive loss of RGCs, resulting in vision loss. While aging and elevated intraocular pressure (IOP) have been identified as the main contributing factors to glaucoma, the molecular mechanisms and signaling pathways triggering RGC death and axonal degeneration are not fully understood. Previous studies in our laboratory found that overactivation of autophagy in DBA/2J::GFP-LC3 mice led to RGC death and optic nerve degeneration with glaucomatous IOP elevation. We found similar findings in aging GFP-LC3 mice subjected to chronic IOP elevation. Here, we further investigated the impact of autophagy deficiency on autophagy-deficient DBA/2J-Atg4bko and DBA/2J-Atg4b+/− mice, generated in our laboratory via CRISPR/Cas9 technology; as well as in Atg4bko mice subjected to the experimental TGFβ2 chronic ocular hypertensive model. Our data shows that, in contrast to DBA/2J and DBA/2J-Atg4b+/− littermates, DBA/2J-Atg4bko mice do not develop glaucomatous IOP elevation. Atg4b deficiency also protected against glaucomatous IOP elevation in the experimental TGFβ2 chronic ocular hypertensive model. Atg4 deletion did not compromise RGC or optic nerve survival in Atg4bko mice. Moreover, our results indicate a protective role of autophagy deficiency against RGC death and ON atrophy in the hypertensive DBA/2J-Atg4b+/− mice. Together, our data suggests a pathogenic role of autophagy activation in ocular hypertension and glaucoma.