bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regression study on fruit‐setting days of purple eggplant fruit based on in situ VIS‐NIRS and attention cycle neural network
Authors: Huang Bohan , Xue Long , Yang Jie , Yin Chaoyang , Liao Keke , Liu Muhua , Li Jing , Shang Mengmeng 
Published: January 2025

AbstractIn the intelligent harvesting of eggplant, the lack of in situ identification technology makes it challenging to determine the maturity of purple eggplant fruit. The length of the fruit‐setting date can determine when the eggplant is ready to be harvested. This study uses deep learning techniques to predict the date of fruit maturity. First, we proposed a fruit‐setting days prediction method based on fruit spectroscopy and neural networks. Second, we collected the field in situ spectral data of purple eggplant fruit during 15–33 days of fruit setting using a portable spectrometer, covering 500–1000 nm. A fruit‐setting time regression network combining multi‐scale convolution, multi‐head attention mechanism, and long short‐term memory recurrent neural network was constructed using the collected in situ spectral data. The model demonstrated better fitting performance than traditional machine learning models such as backpropagation neural network, random forest, support vector machine, and partial least squares regression in the regression task of fruit‐setting days. After testing various spectral preprocessing methods, the best fitting effect was found on the standard normal variate–processed dataset, with R2 of 0.876 and RMSE(root mean square error) of 2.148 days. Furthermore, the feasibility of each model module was analyzed in depth through ablation experiments, confirming each component's role in improving the model's performance. The network attention weight was also analyzed, and the model has strong detail mining ability in a specific spectral interval. In summary, the combination of visible and near‐infrared spectroscopy and attention cycle neural network is an effective method to predict the fruit‐setting days of purple eggplant fruit.Practical Application
A prediction method of fruit‐setting days based on fruit spectral characteristics and recurrent neural network regression was proposed.
A novel approach to detecting and disclosing in situ surface VIS‐NIRS reflectance data of eggplant fruit during ripening is presented for the first time.
A set of long‐term and short‐term memory networks based on multi‐scale convolution and multi‐head attention mechanisms was constructed for spectral data fitting.
Through the ablation test method and attention weight analysis, the function of each module in the network and the interpretability of feature extraction are explored.
Visual annual reports and stock price crash risk
Authors: Xiang Rui , Song Congmin , Lin Rongyu , Shen Lu 
Published: January 2025

AbstractUsing a sample of Chinese A‐Share listed companies during 2018–2023, we explore the influence of visual annual reports (VARs) on stock price crash risk. The results suggest that VARs are negatively associated with crash risk, and several robustness and endogeneity examinations validate our primary findings. Mechanism analyses reveal that reduced information asymmetry and increased internal control quality may serve as potential pathways through which VARs influence crash risk. Additionally, cross‐sectional examinations suggest that the negative relation between VARs and crash risk is more pronounced for companies with poor annual report readability and limited external monitoring.
Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial
Authors: Aktas Ozge Nur , Mateja Allyson , Li Min (Jenny) , Chatman Lindsay , Grieco Megan C. , Baloh Carolyn H. , Huffaker Michelle , Wheatley Lisa M. , du Toit George , Lack Gideon , Brittain Erica , Frischmeyer‐Guerrerio Pamela A. 
Published: January 2025

ABSTRACTBackgroundIntestinal barrier dysfunction may lead to a break in tolerance and development of food allergy (FA). There is contradictory evidence on whether intestinal permeability (IP) is altered in IgE‐mediated FA. Thus, we sought to determine whether IP differed between children with eczema who did (FA group) or did not (atopic controls, ACs) develop FA and whether peanut sensitization, allergy, and early introduction impacted IP using serum biomarkers zonulin, soluble CD14, and Intestinal Fatty Acid Binding Protein among randomly selected participants enrolled in the Learning Early About Peanut allergy trial.MethodsFA group was defined as having at least one FA at either baseline (4–11 months) or 60 months of age (V60). ACs had eczema at baseline and no FA at either visit. Serum IP markers (sIPMs) were measured by ELISA at baseline and V60, and their relationship with the clinical characteristics of participants was analyzed using parametric tests and linear regression models.ResultsWe evaluated 237 FA subjects and 76 ACs. sIPM levels were similar in FA subjects and ACs at baseline and V60. Age when the child first developed any FA (< 1 year vs. > 1 year), eczema severity, peanut sensitization, peanut allergy, and early peanut introduction were not statistically significantly associated with sIPM levels. Total IgE and eosinophil levels, peanut‐specific IgE, IgG4, and IgG4/IgE ratio were not correlated with sIPM levels.ConclusionsNo differences in sIPMs were detected to support altered IP in infants with FA compared to ACs or following early peanut introduction among peanut‐sensitized children.
Cardiomyocyte engineering: The meeting point of transcription factors, signaling networks, metabolism and function
Authors: Piven Oksana O. , Vaičiulevičiūtė Raminta , Bernotiene Eiva , Dobrzyn Pawel 
Published: January 2025

AbstractDirect cardiac reprogramming or transdifferentiation is a relatively new and promising area in regenerative therapy, cardiovascular disease modeling, and drug discovery. Effective reprogramming of fibroblasts is limited by their plasticity, that is, their ability to reprogram, and depends on solving several levels of tasks: inducing cardiomyocyte‐like cells and obtaining functionally and metabolically mature cardiomyocytes. Currently, in addition to the use of more classical approaches such as overexpression of exogenous transcription factors, activation of endogenous cardiac transcription factors via controlled nucleases, such as CRISPR, represents another interesting way to obtain cardiomyocytes. Therefore, special attention is given to the potential of synthetic biology, in particular the CRISPR system, for the targeted conversion of only certain subpopulations of fibroblasts into cardiomyocytes. However, obtaining functionally and metabolically mature cardiomyocytes remains a challenge despite the range of recently developed approaches. In this review, we summarized current knowledge on the function and diversity of human cardiac fibroblasts and alternative cell sources for in vitro human cardiomyocyte models. We examined in detail the transcription factors that initiate cardiomyogenic reprogramming and their interactions. Additionally, we critically analyzed the strategies used for the metabolic and physiological maturation of induced cardiomyocytes.
IgE and cardiac disease
Authors: Levick Scott P. 
Published: January 2025

AbstractIgE acts primarily via the high affinity IgE receptor (FcεRI) and is central to immediate hypersensitivity reactions (anaphylaxis). However, IgE is also important in the development of chronic hypersensitivity reactions (allergy). In the cardiovascular system, numerous clinical studies have investigated serum IgE levels, mainly in the context of myocardial infarction, and have established a clear association between IgE and ischemic cardiac events. While animal studies demonstrate that IgE can cause atherosclerotic plaque formation, this is complicated by clinical reports that IgE is associated with non‐fatal ischemic events and not with fatal events, raising the possibility that IgE could be protective in this setting. In terms of non‐ischemic cardiac disease, little information is available clinically for IgE; however, animal models also indicate that IgE promotes adverse effects in this setting as well. This review article will present the clinical studies that have established a relationship between serum IgE levels and cardiac disease, particularly myocardial infarction. This review article will also discuss animal studies that provide mechanistic understanding of how IgE can exert chronic effects in the heart. This article also attempts to address the question of whether IgE is causative of cardiac disease or is a response to cardiac disease.
Transient receptor potential melastatin 7 cation channel, magnesium and cell metabolism in vascular health and disease
Authors: Abidin Belma Melda , Rios Francisco J. , Montezano Augusto C. , Touyz Rhian M. 
Published: January 2025

AbstractPreserving the balance of metabolic processes in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), is crucial for optimal vascular function and integrity. ECs are metabolically active and depend on aerobic glycolysis to efficiently produce energy for their essential functions, which include regulating vascular tone. Impaired EC metabolism is linked to endothelial damage, increased permeability and inflammation. Metabolic alterations in VSMCs also contribute to vascular dysfunction in atherosclerosis and hypertension. Magnesium (Mg2+) is the second most abundant intracellular divalent cation and influences molecular processes that regulate vascular function, including vasodilation, vasoconstriction, and release of vasoactive substances. Mg2+ is critically involved in maintaining cellular homeostasis and metabolism since it is an essential cofactor for ATP, nucleic acids and hundreds of enzymes involved in metabolic processes. Low Mg2+ levels have been linked to endothelial dysfunction, increased vascular tone, vascular inflammation and arterial remodeling. Growing evidence indicates an important role for the transient receptor potential melastatin‐subfamily member 7 (TRPM7) cation channel in the regulation of Mg2+ homeostasis in EC and VSMCs. In the vasculature, TRPM7 deficiency leads to impaired endothelial function, increased vascular contraction, phenotypic switching of VSMCs, inflammation and fibrosis, processes that characterize the vascular phenotype in hypertension. Here we provide a comprehensive overview on TRPM7/Mg2+ in the regulation of vascular function and how it influences EC and VSMC metabolism such as glucose and energy homeostasis, redox regulation, phosphoinositide signaling, and mineral metabolism. The putative role of TRPM7/Mg2+ and altered cellular metabolism in vascular dysfunction and hypertension is also discussed.
Cultural Brokering in Immigrant Families
Authors: Subramoney Sivenesi , Walle Eric A. , Main Alexandra , Magaña Dalia 
Published: January 2025

ABSTRACTCultural brokering refers to the process of youth (i.e., children, adolescents, and emerging adults) from immigrant families interpreting cultural norms for others. Cultural brokering is not an acontextual, individual, or passive experience but varies by context (e.g., situational demands), is interpersonal (e.g., involves the broker and a social partner), and involves the cultural broker serving as a socializing agent. While researchers have sought to understand how cultural brokering affects the broker (i.e., the individual interpreting for others), findings vary. In this article, we advance the understanding of cultural brokering across development by drawing attention to pertinent aspects of this experience that have been largely overlooked. First, we review distinct forms of cultural brokering. Next, we consider how cultural brokering affects the psychological adjustment and well‐being of immigrant youth. Finally, we suggest research to deepen the understanding of cultural brokering across development.
Featured Cover
Authors: Mutlu Mehmet Burak , Karakaya Taner , Çelebi Hamide Betül Gerik , Duymuş Fahrettin , Seyhan Serhat , Yılmaz Sanem , Yiş Uluç , Atik Tahir , Yetkin Mehmet Fatih , Gümüş Hakan 
Published: January 2025

The cover image is based on the article Utility of Optical Genome Mapping in Repeat Disorders by Mehmet Burak Mutlu et al., https://doi.org/10.1111/cge.14633.
image
Segmental colectomy versus total proctocolectomy for ulcerative colitis: A systematic review and meta‐analysis
Authors: Lincango Eddy P. , Dominguez Oscar Hernandez , Connelly Tara M. , Sobrado Lucas F. , Sancheti Himani , Liska David , Lipman Jeremy , Kessler Hermann , Bhama Anuradha , Kanters Arielle E. , Valente Michael , Hull Tracy , Holubar Stefan D. , Steele Scott R. 
Published: January 2025

AbstractAimTotal proctocolectomy (TPC) is the standard of care for patients with ulcerative colitis (UC) and dysplasia not amenable to endoscopic management. However, the risks of an extensive resection may outweigh the benefits in high‐risk surgical patients. Therefore, we performed a systematic review and meta‐analysis to assess postoperative outcomes between segmental colectomy (SEG) versus TPC in patients with UC.Study designGlobal databases were searched from inception until August 2022 for comparative studies reporting the postoperative outcomes of patients with UC undergoing SEG versus TPC. The primary outcomes were subsequent neoplasia development and overall survival. Odds ratios (ORs), hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated. The Newcastle–Ottawa Scale and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) were used for quality‐of‐evidence assessment.ResultsEight retrospective studies comprising 4856 patients were included. Overall, 1620 (33%) patients underwent SEG. SEG patients were older, had more comorbidities and mostly underwent right colectomy (40%) and sigmoidectomy (16%). Most studies included UC patients and concomitant colorectal cancer. Reoperation and Clavien–Dindo III–IV odds were equivalent (OR 3.17; 95% CI 0.12, 81.25; I2 66%; OR 0.79; 95% CI 0.48, 1.31; I2 74%). There was no difference in neoplasia development (OR 5.05, 95% CI 0.37, 68.66; I2 61%) nor in overall survival (HR 1.20, 95% CI 0.73, 1.97; I2 61%). The risk of bias was high in all included studies and the quality of evidence was low.ConclusionLow‐quality evidence failed to demonstrate any discernible differences in the postoperative outcomes between SEG and TPC. However, given the limited granularity of the analysed data and the high likelihood of imprecise results, we cannot assert that SEG and TPC are equivalent. Furthermore, there was a suggestion of an elevated risk of neoplasia development and inferior overall survival in the SEG group.
Intergenerational Living: Thai Cultural Frictions and Taboos in Changing Times
Authors: SUPAWATANAKUL ADISORN , TANMAHASMUT PIYATHEP 
Published: January 2025

As extended families grow in number, property development in Thailand increasingly focuses on single‐family homes. Our client, Magnolias Quality Development Corporation (MQDC), has introduced a new property brand centered on intergenerational living, embracing the Thai traditional concept of “Katanyu,” gratitude. While the benefits of such living arrangements are widely discussed, there is limited information on the associated challenges due to their taboo nature.These research projects were initiated to understand how family members coexist under one roof while maintaining their relationships, following Thai reciprocity norms. The findings reveal that intergenerational households face complex dynamics in family relationships and living spaces. These dynamics are influenced by shifting financial power and the evolving lifestyles of the younger generation. We also seek to explore how thoughtful space design can alleviate tensions within the family, fostering harmony among intergenerational families who embrace the Katanyu concept.
What You Find When You Find No One: Finding the Light out of Darkness
Authors: JANISSE LAURA , DAILEY FRANCES DiMARE 
Published: January 2025

In the past year, our team encountered unexpected friction when recruiting efforts resulted in zero participants for two different user populations on two health projects. For one project, we were searching for women experiencing pain related to their perimenopause. And for the other project, we were searching for people who were in early stages of their chronic kidney disease. We hadn't experienced finding no one before. We were forced to pause and question our approach and work. It all felt heavy – zero recruits, the need to find direction for what to do next, and ability to discover the insight for why this happened. Finding no one had critical design and business impact for our team and cross‐functional partners.Join us as we share how we emerged from the darkness of zero, how we found motivation to push through and unpack the friction, and how we ended up in a better position because of zero. We hope our story helps the community see friction as a gift when they encounter it in the future, and that it inspires us, as research practitioners, to question what blind spots might exist within our practice and work.
Effects of Bank Capital and Lending on Leverage, Risk, and Growth of Nonfinancial Firms
Authors: Baran Lindsay , Patel Ajay , Sorokina Nonna 
Published: January 2025

ABSTRACTThis paper examines the impact of bank capital on the capital structure of nonfinancial firms, focusing on lenders and commercial borrowers from 2000 to 2019. We find a positive relationship between firm leverage and bank capital, with lending serving as a key channel for this effect. Additionally, increased lending is associated with higher firm risk and slower growth. Our deal‐level analysis reveals consistent findings with those at the firm level: greater lending is linked to higher spreads, more tranches, more secured loans, fewer lenders per deal, and longer maturities, all of which indicate increased borrower risk. This study offers new insights into how bank capital structure policies influence the financial structure of nonfinancial firms and contributes to the broader debate on the spillover effects of risk‐reduction measures in the financial sector, such as capital regulation, on the real economy.
A survey of NHS nurses' delivery of treatments to prevent recurrence of venous leg ulcers
Authors: Alkahtani Abeer Muflih , Dumville Jo C. , Armitage Christopher J. 
Published: January 2025

AbstractPreventing recurrence of venous leg ulcers can be achieved through strongest tolerated compression and endo‐venous ablation surgery, but it is not clear how often this is done in practice. This study explores (1) nurses' awareness of strongest tolerated compression and endo‐venous ablation surgery as prophylactic treatments for venous leg ulcer, (2) how often these treatments are offered, and (3) assessment of the barriers and enablers to deploying those treatments using the capabilities, opportunities and motivations model of behaviour change. An online cross‐sectional survey was conducted among nurses who treat and manage venous leg ulcers across the United Kingdom. Data were analysed descriptively using within‐participants ANOVA, within‐participants MANOVA and multiple linear regression. We received 96 questionnaire responses. All the respondents reported that they were aware of strongest compression to prevent recurrence while 87.5% reported they were aware of endo‐venous ablation surgery for recurrence prevention. Nurses' capabilities, opportunities, and motivations to offer the strongest tolerated compression were significantly greater when offering the strongest compression compared with referring to vascular surgery. Both preventative treatments were associated with marked deficits in opportunities (social and physical) and automatic motivation. Interventions targeted at increasing nurses' opportunities and boosting their motivation are needed to support the delivery of both preventive treatments. Further research is required to gain in‐depth understanding of those barriers and enablers to identify candidate behaviour change techniques.
Comprehensive cost‐of‐illness analysis of pressure ulcer treatment: A real‐world study at a Czech university hospital
Authors: Krupová Lenka , Pokorná Andrea , Krupa Miroslav , Benešová Klára 
Published: January 2025

AbstractPressure ulcers (PUs) impose a significant economic burden on healthcare systems, affecting patient quality of life and leading to substantial treatment costs. This study presents a cost‐of‐illness analysis of PU treatment in hospitalized patients in the Czech Republic, based on real‐world clinical data. The analysis was conducted using a comprehensive methodology at a Czech university hospital, involving 304 hospitalizations. The study included all hospitalized patients with PUs. Data were collected employing a bottom‐up, person‐based approach, which refers to the collection and analysis of cost data at the individual patient level. This method captures detailed resource utilization for each patient. The methodology accounted for both systemic and local costs, including materials, medications, caregiver time, and procedures. The study involved 304 hospitalizations, with a mean length of stay of 13 days. The total cost of PU treatment, excluding pharmacotherapy, had a median of €678, while including pharmacotherapy, the median cost rose to €929. Younger patients incurred higher treatment costs. Significant cost variations were observed among different departments. We developed and applied a novel cost model to quantify the expenses associated with PUs, which accurately highlighted the financial burden in the hospital care setting. We present a rigorous methodology for PU cost‐of‐illness analysis, providing a valuable tool for future research and clinical practice. This comprehensive approach supports the development of targeted interventions to reduce the incidence and severity of PUs, ultimately improving patient care and reducing healthcare costs.
Six‐Month Emergent Readmissions Following Hospitalization for Atrial Fibrillation Amid the Syrian Conflict: A Real‐World Observational Cohort Study
Authors: Antoun Ibrahim , Alkhayer Alkassem , Alkhayer Alamer , Yazji Khaled , Somani Riyaz , Ng G. André , Zakkar Mustafa 
Published: January 2025

ABSTRACTBackgroundAtrial fibrillation (AF) is the most common arrhythmia worldwide. However, data regarding readmissions following index admission for AF in the developing world are not well described. This study assessed the rate, predictors, and trends of 6‐month readmission after index admission for AF in Syria.MethodsWe included adult patients who had an index admission with AF to Latakia's tertiary center between July 2021 and November 2023. Patients were monitored for readmission for 6 months after index discharge. Data were taken from the patient's medical notes.ResultsA total of 649 patients were included in the final analysis, of which 320 (49%) were readmitted to the hospital within 6 months following index admission. Cardiac causes were the most common cause of readmission in 76% of patients, of which 70% were AF. Readmitted patients had a higher median age (64 vs. 58; p = 0.001) and fewer males (49% vs. 36%; p = 0.001). In multivariate analysis, factors that independently increased 6‐month readmission risk were age ≥ 60 years (hazard ratio [HR]: 1.7, 95% CI: 1.4−2.2), females (HR: 2.2, 95% CI: 1.6−2.7), and congestive heart failure (CCF) (HR: 2.1, 95% CI: 1.4−2.6). Most cardiac readmissions (76%) happened during the first 60 days following index discharge.ConclusionAlmost half the patients were readmitted within 6 months after an index admission for AF. Females, CCF, and advancing age were independently associated with an increased risk of 6‐month readmission.