bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins
Authors: Roefs Marieke Theodora , Bauzá-Martinez Julia , van de Wakker Simonides Immanuel , Qin Jiabin , Olijve Willem Theodoor , Tuinte Robin , Rozeboom Marjolein , Snijders Blok Christian , Mol Emma Alise , Wu Wei , Vader Pieter , Sluijter Joost Petrus Gerardus 
Published: August 2023

AbstractExtracellular vesicles (EVs) are cell-derived lipid bilayer-enclosed particles that play a role in intercellular communication. Cardiac progenitor cell (CPC)-derived EVs have been shown to protect the myocardium against ischemia-reperfusion injury via pro-angiogenic effects. However, the mechanisms underlying CPC-EV-induced angiogenesis remain elusive. Here, we discovered that the ability of CPC-EVs to induce in vitro angiogenesis and to stimulate pro-survival pathways was lost upon EV donor cell exposure to calcium ionophore. Proteomic comparison of active and non-active EV preparations together with phosphoproteomic analysis of activated endothelial cells identified the contribution of candidate protein PAPP-A and the IGF-R signaling pathway in EV-mediated cell activation, which was further validated using in vitro angiogenesis assays. Upon further purification using iodixanol gradient ultracentrifugation, EVs partly lost their activity, suggesting a co-stimulatory role of co-isolated proteins in recipient cell activation. Our increased understanding of the mechanisms of CPC-EV-mediated cell activation will pave the way to more efficient EV-based therapeutics.
General formalism of the quantum equivalence principle
Authors: Das Saurya , Fridman Mitja , Lambiase Gaetano 
Published: August 2023

AbstractA consistent theory of quantum gravity will require a fully quantum formulation of the classical equivalence principle. Such a formulation has been recently proposed in terms of the equality of the rest, inertial and gravitational mass operators, and for non-relativistic particles in a weak gravitational field. In this work, we propose a generalization to a fully relativistic formalism of the quantum equivalence principle, valid for all background space-times, as well as for massive bosons and fermions. The principle is trivially satisfied for massless particles. We show that if the equivalence principle is broken at the quantum level, it implies the modification of the standard Lorentz transformations in flat space-time and a corresponding modification of the metric in curved space-time by the different mass ratios. In other words, the observed geometry would effectively depend on the properties of the test particle. Testable predictions of potential violations of the quantum equivalence principle are proposed.
Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid
Authors: Gagliardi Geoffroy , Rodriguez-Vieitez Elena , Montal Victor , Sepulcre Jorge , Diez Ibai , Lois Cristina , Hanseeuw Bernard , Schultz Aaron P. , Properzi Michael J. , Papp Kathryn V. , Marshall Gad A. , Fortea Juan , Johnson Keith A. , Sperling Reisa A. , Vannini Patrizia 
Published: August 2023

AbstractIntroductionNon-invasive diffusion-weighted imaging (DWI) to assess brain microstructural changes via cortical mean diffusivity (cMD) has been shown to be cross-sectionally associated with tau in cognitively normal older adults, suggesting that it might be an early marker of neuronal injury. Here, we investigated how regional cortical microstructural changes measured by cMD are related to the longitudinal accumulation of regional tau as well as to episodic memory decline in cognitively normal individuals harboring amyloid pathology.Methods122 cognitively normal participants from the Harvard Aging Brain Study underwent DWI, T1w-MRI, amyloid and tau PET imaging, and Logical Memory Delayed Recall (LMDR) assessments. We assessed whether the interaction of baseline amyloid status and cMD (in entorhinal and inferior-temporal cortices) was associated with longitudinal regional tau accumulation and with longitudinal LMDR using separate linear mixed-effects models.ResultsWe find a significant interaction effect of the amyloid status and baseline cMD in predicting longitudinal tau in the entorhinal cortex (p = 0.044) but not the inferior temporal lobe, such that greater baseline cMD values predicts the accumulation of entorhinal tau in amyloid-positive participants. Moreover, we find a significant interaction effect of the amyloid status and baseline cMD in the entorhinal cortex (but not inferior temporal cMD) in predicting longitudinal LMDR (p < 0.001), such that baseline entorhinal cMD predicts the episodic memory decline in amyloid-positive participants.ConclusionsThe combination of amyloidosis and elevated cMD in the entorhinal cortex may help identify individuals at short-term risk of tau accumulation and Alzheimer’s Disease-related episodic memory decline, suggesting utility in clinical trials.
Deep extractive and catalytic oxidative desulfurization of liquid fuels by using iron(iii) based dication ionic liquids
Authors: Zafar Anham , Din Imtiaz-ud- , Batool Saadia , Palgrave Robert G. , Yousuf Sammer 
Published: August 2023

Five new dicationic ionic liquids(1–5), with varying lengths of alkyl chain and [FeCl3Br]− as the counter anion, have been synthesized, characterized by using FT-IR, Raman spectroscopy, and mass spectrometry besides single crystal X-ray analysis.
Understanding ZIF particle chemical etching dynamics and morphology manipulation: in situ liquid phase electron microscopy and 3D electron tomography application
Authors: Chang Qiang , Yang Dahai , Zhang Xingyu , Ou Zihao , Kim Juyeong , Liang Tong , Chen Junhao , Cheng Sheng , Cheng Lixun , Ge Binghui , Ang Edison Huixiang , Xiang Hongfa , Li Mufan , Song Xiaohui 
Published: August 2023

In situ liquid phase transmission electron microscopy (TEM) and three-dimensional electron tomography are powerful tools for investigating the etching mechanism of MOFs and quantifing the particles morphology.
G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB/N mice
Authors: Vieira Pimentel Renata Lúcia , Braga Janaína Félix , Velloso Elizabeth Portugal Pimenta , Lautner Roberto Queiroga , de Oliveira Marilene Luzia , Todiras Mihail , Alenina Natalia , Bader Michael , de Sousa Felipe Gaia , Beier Suzane Lilian , Santos RAS 
Published: August 2023

Abstract
Background: An unbalance in the renin-angiotensin (Ang) system (RAS) between the Ang II/AT1 and Ang-(1-7)/Mas axis appears to be involved in preeclampsia (PE), in which a reduction in Ang-(1-7) was observed. Here, we tested whether the reduction in the activity of the Ang-(1-7)/Mas axis could be a contributing factor for the development of PE, using Mas-deficient (Mas−/−) mice. Methods and results: Cardiovascular parameters were evaluated by telemetry before, during pregnancy and 4 days postpartum in 20-week-old Mas−/− and wild-type (WT) female mice. Mas−/− mice presented reduced arterial blood pressure (BP) at baseline (91.3 ± 0.8 in Mas−/− vs. 94.0 ± 0.9 mmHg in WT, Diastolic, P&lt;0.05). However, after the 13th day of gestation, BP in Mas−/− mice started to increase, time-dependently, and at day 19 of pregnancy, these animals presented a higher BP in comparison with WT group (90.5 ± 0.7 in Mas−/− vs. 80.3 ± 3.5 mmHg in WT, Diastolic D19, P&lt;0.0001). Moreover, pregnant Mas−/− mice presented fetal growth restriction, increase in urinary protein excretion as compared with nonpregnant Mas−/−, oliguria, increase in cytokines, endothelial dysfunction and reduced ACE, AT1R, ACE2, ET-1A, and eNOS placental mRNA, similar to some of the clinical manifestations found in the development of PE. Conclusions: These results show that Mas-deletion produces a PE-like state in FVB/N mice.
Flow of gas detected from beyond the filaments to protostellar scales in Barnard 5
Authors: Valdivia-Mena M. T. , Pineda J. E. , Segura-Cox D. M. , Caselli P. , Schmiedeke A. , Choudhury S. , Offner S. S. R. , Neri R. , Goodman A. , Fuller G. A. 
Published: August 2023

Context. The infall of gas from outside natal cores has proven to feed protostars after the main accretion phase (Class 0). This changes our view of star formation to a picture that includes asymmetric accretion (streamers), and a larger role of the environment. However, the connection between streamers and the filaments that prevail in star-forming regions is unknown.
Aims. We investigate the flow of material toward the filaments within Barnard 5 (B5) and the infall from the envelope to the protostellar disk of the embedded protostar B5-IRS1. Our goal is to follow the flow of material from the larger, dense core scale, to the protostellar disk scale.
Methods. We present new HC3N line data from the NOEMA and 30 m telescopes covering the coherence zone of B5, together with ALMA H2CO and C18O maps toward the protostellar envelope. We fit multiple Gaussian components to the lines so as to decompose their individual physical components. We investigated the HC3N velocity gradients to determine the direction of chemically fresh gas flow. At envelope scales, we used a clustering algorithm to disentangle the different kinematic components within H2CO emission.
Results. At dense core scales, HC3N traces the infall from the B5 region toward the filaments. HC3N velocity gradients are consistent with accretion toward the filament spines plus flow along them. We found a ~2800 au streamer in H2CO emission, which is blueshifted with respect to the protostar and deposits gas at outer disk scales. The strongest velocity gradients at large scales curve toward the position of the streamer at small scales, suggesting a connection between both flows.
Conclusions. Our analysis suggests that the gas can flow from the dense core to the protostar. This implies that the mass available for a protostar is not limited to its envelope, and it can receive chemically unprocessed gas after the main accretion phase.
Open reduction and polyaxial plating for stemmed knee periprosthetic fractures: A case series
Authors: Gonzalez-Morgado Diego , Andres-Peiro Jose Vicente , Selga Marsa Jordi , Alberto Piedra Calle Carlos , Francesc Nomdedeu Sancho Josep , Teixidor Serra Jordi , Tomas Hernandez Jordi 
Published: August 2023

Introduction: Stemmed total knee arthroplasty (STKA) periprosthetic fractures (PPFs) are an emerging problem affecting frail patients. Their surgical fixation is challenging, due to intramedullary involvement and poor bone stock. Polyaxial locking plating has yielded good results in implant-related femur fractures. We hypothesized that this treatment would provide similar results for STKA PPFs. Methods: Retrospective analysis of consecutive patients with a femoral PPF or inter-implant fracture around a knee revision stem who had undergone open reduction and periprosthetic-specific polyaxial plate fixation. Results: We found 14 cases of mean age 85.4 years. Cerclages were used in 80% of cases. Fixation of a mean 8.6 cortices around the revision stem was achieved, with an overall screw density of 1:2 or 1:3. Four patients lost their ability to walk, while four experienced postoperative local complications. Bone healing was achieved in all except one who died during hospitalization. The 13 remaining survived the first year of follow-up. Conclusion: STKA PPFs are an emerging and challenging problem affecting frail patients. Treatment using polyaxial locking plates provides stable fixation allowing early mobilization despite high complication rates.
Alle Kinder fit für die Schule? Die Gestaltung des
Entwicklungsscreenings im Rahmen der Schuleingangsuntersuchung in
Deutschland
Authors: Preuschhof Claudia , Küster Tess , Rademacher Jeanne , Baumgarten Melanie 
Published: August 2023

ZusammenfassungDie Schuleingangsuntersuchung (SEU) liefert wichtige Informationen zum
Förderbedarf eines Kindes und für die
Gesundheitsberichterstattung. Die SEU sollte den neuesten Stand der Wissenschaft
abbilden und Daten von hoher Qualität erzeugen. Dazu muss sie
wissenschaftlichen Gütekriterien genügen sowie
fortwährend evaluiert und weiterentwickelt werden. In Anbetracht der
Relevanz der Daten und des hohen Personalaufwandes muss sich die SEU in Bezug
auf Sinnhaftigkeit, Inhalte und Struktur einer wissenschaftlichen und
öffentlichen Debatte stellen. Dafür ist eine transparente
Kommunikations- und Veröffentlichungspraxis erforderlich. Der
vorliegende Übersichtsartikel hat das Ziel, die öffentlich
verfügbaren Informationen zu Vorgaben der einzelnen Länder
bezüglich Entwicklungsscreenings in der SEU zusammenzutragen und
hinsichtlich Transparenz, Vollständigkeit und wissenschaftlicher
Güte zu bewerten. Während die erfassten Entwicklungsbereiche
stark übereinstimmen, bestehen große Unterschiede im Zeitpunkt
der SEU, ob ein ein- bzw. mehrstufiges Verfahren eingesetzt wird und inwieweit
alle Kinder von Ärzt*innen des Öffentlichen
Gesundheitsdienstes (ÖGD) untersucht werden. SOPESS ist das am
häufigsten in Deutschland eingesetzte Verfahren, für welches
auch hinreichende Gütekriterien aufgezeigt wurden. Für einige
breitflächig eingesetzte Verfahren fehlen vor allem Validierung und
Normierung. Insgesamt gibt es wenig öffentlich verfügbare
Informationen oder wissenschaftliche Publikationen zur SEU durch den
ÖGD. Die Heterogenität der eingesetzten Verfahren in Deutschland
kann als eine Chance für die Weiterentwicklung und Verbesserung der SEU
betrachtet werden. Wünschenswert hierfür wäre eine
kontinuierliche Kommunikation zwischen Verantwortlichen in den Ländern,
eine gründliche wissenschaftliche Begleitung sowie öffentliche
Debatte.
Aminoacylation of Alkenes by Cooperative NHC and Photoredox Catalysis
Authors: Lezius Lena , Reimler Jannik , Studer Armido , Döben Nadine , Hamm Michael , Daniliuc Constantin G. 
Published: August 2023

AbstractCooperative NHC and photoredox catalysis has gained significant attention as an emerging research field in recent years. Herein, we report a cyclizing aminoacylation of alkenes, which is enabled through the combination of these two catalytic modes. The key step is a radical/radical cross-coupling between a persistent ketyl radical and a transient benzylic or aliphatic C-radical, which is generated through radical cyclization of an oxidatively formed amidyl radical. Several carbamates, amides and sulfonamides containing an alkene moiety and different acyl fluorides can be used as substrates. The resulting products are obtained in moderate to good yields.
Time-frequency volatility spillovers between Chinese renminbi onshore and offshore markets during the COVID-19 crisis
Authors: Wang Liang , Xiong Xianyan , Cao Ziqiu 
Published: August 2023

AbstractThis article investigates the time-frequency volatility spillovers between Chinese renminbi onshore and offshore markets during the COVID-19 crisis. By employing wavelet analysis, we find that: (i) As the timescale increases, the volatility spillovers between renminbi onshore and offshore markets are gradually significant and bidirectional, and they have increased significantly after the COVID-19 outbreak. (ii) The significant volatility spillovers of the two markets are decomposed into many sub-spillovers on different timescales, most possibly precipitated by heterogeneous behaviors across various investment horizons. (iii) During the COVID-19 crisis, the onshore market has the dominant position on price discovery and leads the offshore market.
Toward time resolved dynamic light scattering microscopy: Retrieving particle size distributions at high temporal resolutions
Authors: Urquidi Oscar , Barbosa Natercia , Brazard Johanna , Adachi Takuji B. M. 
Published: August 2023

Dynamic light scattering (DLS) is a widely applied technique in multiple scientific and industrial fields for the size characterization of nanoscale objects in solution. While DLS is typically applied to characterize systems under static conditions, the emerging interest in using DLS on temporally evolving systems stimulates the latent need to improve the time resolution of measurements. Herein, we present a DLS microscopy setup (micro-DLS) that can accurately characterize the size of particles from autocorrelation functions built from sub-100 ms time windows, several orders of magnitude faster than previously reported. The system first registers the arrival time of the scattered photons using a time-correlated single photon counting module, which allows the construction of the autocorrelation function for size characterization based on a time window of freely chosen position and width. The setup could characterize both monomodal (60 or 220 nm polystyrene particles; PS) and multimodal size distributions (e.g., mixture of 20 nm LUDOX and 80 nm PS) with high accuracy in a sub-100 ms time window. Notably, the width of the size distribution became narrower as a shorter time window was used. This was attributed to the ability of the system to resolve the sub-ensemble of the broad size distribution, as the broad distribution could be reconstructed by accumulating the distribution obtained by consecutive 80 ms time windows. A DLS system with high temporal resolution will accelerate the expansion of its application toward systems that evolve as a function of time beyond its conventional use on static systems.
Estimating Mediterranean stand fuel characteristics using handheld mobile laser scanning technology
Authors: Coskuner Kadir Alperen , Vatandaslar Can , Ozturk Murat , Harman Ismet , Bilgili Ertugrul , Karahalil Uzay , Berber Tolga , Tunc Gormus Esra 
Published: August 2023

Background Accurate, timely and easily obtainable information on stand fuel is of great importance in the prediction of fire behaviour. Aims The objective of this study is to measure several stand fuel characteristics with handheld mobile laser scanning (HMLS) in six fuel types for Mediterranean region, and compare the results with traditional field fuel measurements (FFM) in 35 different sampling plots. Methods The measurements involved overstorey (the number of trees, diameter at breast height, crown base height, tree height, maximum tree height, stand crown closure) and understorey (understorey closure, understorey height) fuel characteristics, and ground slope. Correlation analysis and t-test were performed to examine the relationship between FFM and HMLS datasets. In addition, cross-validation statistics (RMSE, rRMSE and R2) were employed to evaluate the accuracy of the HMLS method. Key results The results indicated strong correlations among all fuel characteristics. However, overstorey fuel characteristics were more favourable (r-values between 0.804 and 0.996, P < 0.01) than understorey (r-values between 0.483 and 0.612, P < 0.01). There was no significant difference between FFM and HMLS datasets in all fuel characteristics (P > 0.05). Conclusions The results indicated that the HMLS was practical, cost-effective, time-efficient and required less labour as compared to traditional FFM in plot-level (i.e. 0.1 ha) inventories.
A critique of the adjacency pair dogma
Authors: Cooren François , Dion Frédéric , Balay Matthieu 
Published: August 2023

Abstract
Drawing inspiration from key authors such as Weick, Taylor and Van Every, Greimas, Goffman, Sbisà, and Tsui, we
propose to explore what we call the basic organizing unit, in other words, the minimal form that a sequence of action must take in
order to claim a certain degree of organizationality. In order to empirically test this proposition, we purposively analyze
interactions taking place outside of a classical organizational context, i.e., street hypnosis sessions. What interests us is not
only how these sessions are organized, but also how they organize themselves. Our aim, therefore, is to identify key moments when
a certain organizationality seems to express itself, an organizationality that we propose to detect through the identification of
these basic organizing units. This leads us to show that the adjacency pair model, which has been historically
defined as a fundamental unit of conversational organization should, in fact, be replaced by our triadic model of interaction.
Constituting climate change in dialogic practice
Authors: Smithberger Leanna 
Published: August 2023

Abstract
In this essay, I present data from a regional climate conference
to demonstrate how speakers engage in dialogic practice to constitute a moral
universe of climate actors. I employ the notion of the science-policy-practice
dialogue to introduce three identity categories – scientist expert, elected
policymaker, and practitioner – which participants use to position themselves
and relate to others and their environments. Using discourse analysis, I attend
to the membership categorization devices speakers use to deploy these identity
categories and constitute the cast of climate characters. Speakers assign
themselves and others to identity categories by making claims to enoughness,
which are then used to establish expectations and justify actions.
Debaters’ actions to manage interaction in the context of the debate talk show
Authors: Vasilyeva Alena L. 
Published: August 2023

Abstract
The project explores how conflict is managed in a debate talk show that addresses the current situation in Belarus and its future. The analysis shows that the debaters act as co-designers of the debate activity. They indicate a variety of moves that they find inappropriate (e.g., personal attacks) and use various interactional resources to challenge these actions, which is done directly (e.g., directly naming inappropriate actions) and indirectly (e.g., nonverbal actions). Their interventions are aimed at managing interaction, but at the same time, they undermine their opponents’ image. Furthermore, the study highlights the importance of identities as an interactional resource to shape interaction. The analysis also demonstrates the role of a multi-party structure of the debate in managing interaction.
“Doing being an involved parent”
Authors: Colla Vittoria 
Published: August 2023

AbstractThe present study investigates the increasingly common phenomenon of parental involvement in children’s education from a dialogic perspective. Drawing on video-recorded parent-child homework conversations in Italian families and adopting a conversation analysis-informed approach, the study analyzes how a value-laden cultural notion like ‘family-school partnership’ is given ‘dialogic existence’ through a variety of discursive practices. Specifically, it identifies four practices deployed by parents when supervising children’s homework: (1) making the teacher speak, (2) drawing parallels between family and school, (3) siding with the teacher, and (4) adopting a teacher-like evaluative stance. Beyond their specificities, all these practices reproduce the school’s institutional culture inside the home. It is argued that, through these practices, parents ‘do being involved’ in homework and implement a partnership based on shared values between family and school.