bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYSIS OF FINANCIAL PERFORMANCE WITH RGEC METHOD AT REGIONAL DEVELOPMENT BANK LISTED ON THE INDONESIAN STOCK EXCHANGE
Authors: Suwedy Suwedy , Kasim Muhammad Yunus , Husnah Husnah 
Published: June 2023

This research intends to analyze the financial performance at Regional Development Banks listed on the Indonesian Stock Exchange for the 2016-2020 period using the RGEC (Risk Profile, Good Corporate Governance, Earnings, Capital). This research applied quantitative descriptive approach. Data were collected through annual financial reports published in each bank of 3 regional banks. Results of this research reveals that the financial performance at regional development Banks listed on the on the Indonesian Stock Exchange for the 2016-2020 period is identified through the Risk Profile, namely by analyzing financing risk with the NPL ratio of regional banks BJBR in the very good category, BJTM in the good category and BEKS is adequate but was not in good category in 2020 period. Liquidity risk analysis with the LDR ratio of regional banks of BJTM for the 2016 period is adequate, the 2017 period is good and in the period of 2018-2020 it is very good, the BJBR bank is in the adequate category and the BEKS bank for the 2016 and 2018 periods is good, the 2017 and 2019 periods it is in category of good, the 2020 period it is not good.

Keywords: Risk Profile, Good Corporate Governance, Earning, Capital (RGEC).
Raptor couples mTORC1 and ERK1/2 inhibition by cardamonin with oxidative stress induction in ovarian cancer cells
Authors: Zhu Yanting , Wang Shifeng , Niu Peiguang , Chen Huajiao , Zhou Jintuo , Jiang Li , Li Danyun , Shi Daohua 
Published: June 2023

Background
A balance on nutrient supply and redox homeostasis is required for cell survival, and increased antioxidant capacity of cancer cells may lead to chemotherapy failure.

Objective
To investigate the mechanism of anti-proliferation of cardamonin by inducing oxidative stress in ovarian cancer cells.

Methods
After 24 h of drug treatment, CCK8 kit and wound healing test were used to detect cell viability and migration ability, respectively, and the ROS levels were detected by flow cytometry. The differential protein expression after cardamonin administration was analyzed by proteomics, and the protein level was detected by Western blotting.

Results
Cardamonin inhibited the cell growth, which was related to ROS accumulation. Proteomic analysis suggested that MAPK pathway might be involved in cardamonin-induced oxidative stress. Western blotting showed that cardamonin decreased Raptor expression and the activity of mTORC1 and ERK1/2. Same results were observed in Raptor KO cells. Notably, in Raptor KO cells, the effect of cardamonin was weakened.

Conclusion
Raptor mediated the function of cardamonin on cellular redox homeostasis and cell proliferation through mTORC1 and ERK1/2 pathways.
Bicol College Ed. D. and Ph. D. Graduates from 2012-2021: A Tracer Study
Authors: Esparrago Milagros 
Published: June 2023

A school tracer study is a research method used to track the progress and outcomes of a school's graduates over time. In addition, school tracer studies can help to identify trends and patterns in education and employment outcomes across different countries and regions, allowing for cross-country comparisons and the identification of best practices. A tracer study on the Master of Science Graduates in Disaster Risk Management of the Central Bicol State University of Agriculture determined the employability of the Master of Science in Disaster Risk Management (MSDRM) graduates to provide input to curriculum innovation. The majority of the tracer studies reviewed were from the undergraduate and master’s levels. This tracer study on graduates of the doctoral programs, EdD and PhD of Bicol College Inc. is a novel undertaking. The descriptive–quantitative research design was used employing the saturated sampling technique. A database of these graduates was established, and it was found that lifelong learning and service to the community are very relevant among doctoral degree graduates. Open career for postdoctoral studies is a challenge to them. Results showed that the majority of the respondents are females, with ages ranging from 40-60 years old. It took them 3-5 years to complete the degree, enroll in the degree program for professional growth and mostly be promoted after completion. Ten respondents obtained recognition and awards at the local, regional, national, and international level. One graduate even passed the Career Executive Service Written Examination, a qualification for directorship.
Análise da aplicação da contabilidade de gestão ambiental em uma indústria salineira
Authors: Lima Eli de Sousa , De Oliveira Auris Martins , Silva Sérgio Luiz Pedrosa , De Oliveira Adriana Martins , Valdevino Rosângela Queiroz Souza , Paiva Antonio Claudio Noberto , Almeida Cássio Rodrigo da Costa , Lopes Jorge Eduardo de Medeiros 
Published: June 2023

A contabilidade de gestão ambiental tem adquirido grande relevo na esfera administrativa das organizações. No entanto, ainda é marcante e visível que muitas empresas têm negligenciado sua aplicação, investindo mais no aspecto meramente financeiro, colocando em segundo plano as questões do meio ambiente. Boa parte dessas organizações, sobretudo as do setor industrial são consideradas as maiores responsáveis pelos impactos ambientais. A contabilidade ambiental é uma ramificação da tradicional, mas não é uma imposição pelo governo, e sim uma ferramenta valorizada e utilizada por gestores que possuem uma visão estratégica sobre o cuidado com a natureza, focada na sustentabilidade. Quanto ao objetivo deste artigo, consiste em saber se a indústria analisada tem consciência da importância da contabilidade de gestão ambiental, bem como se a mesma a utiliza no processo administrativo. Como metodologia, foi realizado um estudo de caso numa empresa do ramo salineiro localizada na cidade Grossos/RN. No que diz respeito ao modelo do plano de contas adotado pela empresa, bem como ao seu orçamento, foi constatado que não é efetuado uma separação entre as contas tradicionais (ativo, passivo, despesa, receita e custo) e as contas ambientais (ativo ambiental, passivo ambiental, despesa ambiental, receita ambiental e custo ambiental). Ao término da pesquisa, pôde-se verificar que a indústria salineira estudada, apesar de atribuir um enorme grau de importância à aplicação da contabilidade de gestão ambiental nas organizações, não a utiliza no processo de gestão dos seus negócios.
Safety of Targeted Axillary Dissection After Neoadjuvant Therapy in Patients With Node-Positive Breast Cancer
Authors: Kuemmel Sherko , Heil Joerg , Bruzas Simona , Breit Elisabeth , Schindowski Dorothea , Harrach Hakima , Chiari Ouafaa , Hellerhoff Karin , Bensmann Elena , Hanf Volker , Graßhoff Sven-Thomas , Deuschle Petra , Belke Kerstin , Polata Silke , Paepke Stefan , Warm Mathias , Meiler Johannes , Schindlbeck Christian , Ruhwedel Wencke , Beckmann Ulrike , Groh Ulrich , Dall Peter , Blohmer Jens-Uwe , Traut Alexander , Reinisch Mattea 
Published: June 2023

ImportanceThe increasing use of neoadjuvant systemic therapy (NST) has led to substantial pathological complete response rates in patients with initially node-positive, early breast cancer, thereby questioning the need for axillary lymph node dissection (ALND). Targeted axillary dissection (TAD) is feasible for axillary staging; however, data on oncological safety are scarce.ObjectiveTo assess 3-year clinical outcomes in patients with node-positive breast cancer who underwent TAD alone or TAD with ALND.Design, Setting, and ParticipantsThe SenTa study is a prospective registry study and was conducted between January 2017 and October 2018. The registry includes 50 study centers in Germany. Patients with clinically node-positive breast cancer underwent clipping of the most suspicious lymph node (LN) before NST. After NST, the marked LNs and sentinel LNs were excised (TAD) followed by ALND according to the clinician’s choice. Patients who did not undergo TAD were excluded. Data analysis was performed in April 2022 after 43 months of follow-up.ExposureTAD alone vs TAD with ALND.Main Outcomes and MeasuresThree-year clinical outcomes were evaluated.ResultsOf 199 female patients, the median (IQR) age was 52 (45-60) years. A total of 182 patients (91.5%) had 1 to 3 suspicious LNs; 119 received TAD alone and 80 received TAD with ALND. Unadjusted invasive disease-free survival was 82.4% (95% CI, 71.5-89.4) in the TAD with ALND group and 91.2% (95% CI, 84.2-95.1) in the TAD alone group (P = .04); axillary recurrence rates were 1.4% (95% CI, 0-54.8) and 1.8% (95% CI, 0-36.4), respectively (P = .56). Adjusted multivariate Cox regression indicated that TAD alone was not associated with an increased risk of recurrence (hazard ratio [HR], 0.83; 95% CI, 0.34-2.05; P = .69) or death (HR, 1.07; 95% CI, 0.31-3.70; P = .91). Similar results were obtained for 152 patients with clinically node-negative breast cancer after NST (invasive disease-free survival: HR, 1.26; 95% CI, 0.27-5.87; P = .77; overall survival: HR, 0.81; 95% CI, 0.15-3.83; P = .74).Conclusions and RelevanceThese results suggest that TAD alone in patients with mostly good clinical response to NST and at least 3 TAD LNs may confer survival outcomes and recurrence rates similar to TAD with ALND.
A Mitochondria‐Targeted NIR‐II AIEgen Induced Pyroptosis for Enhanced Tumor Immunotherapy
Authors: Yu Kaiwu , Ye Binglin , Yang Huang , Xu Xinxin , Mao Zhengwei , Zhang Qinghua , Tian Mei , Zhang Haoke , Zhang Hong , He Qinggang 
Published: June 2023

AbstractCancer immunotherapy is a favorable strategy for facilitating anti‐tumor immunity, but it shows limited benefits in clinical practice owing to the immunosuppressive tumor microenvironment. Pyroptosis shows great immunostimulatory effect on tumor, whereas the lack of pyroptotic inducer with imaging property has restricted its progress in tumor theranostics. Herein, a mitochondria‐targeted aggregation‐induced emission (AIE) luminogen (TPA‐2TIN) with NIR‐II emission is designed for highly efficient induction of tumor cell pyroptosis. The fabricated TPA‐2TIN nanoparticles can be efficiently taken up by tumor cells and selectively accumulated in tumor for a long term observed by NIR‐II fluorescence imaging. More importantly, the TPA‐2TIN nanoparticles can effectively stimulate immune responses both in vitro and in vivo mediated by the mitochondrial dysfunctions and the subsequent activation of the pyroptotic pathway. Ultimately, the reversal of the immunosuppressive tumor microenvironment significantly enhances the immune checkpoint therapy. This study paves a new avenue for adjuvant immunotherapy of cancer.
Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers
Authors: Ihara Yuta , Yamagishi Hiroshi , Naito Masanobu , Yamamoto Yohei 
Published: June 2023

AbstractMachine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large datasets. Here, we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical space. For constructing a dataset, four polymers were precipitated from 416 solvent/nonsolvent combinations, and the morphology of the resulting precipitates were collected. The dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector machine. Thereby, we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation behavior. The predicted appropriate solvents are those with low hydrogen bonding capability, low polarity, and small molecular volume. Furthermore, we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space, which is the origin of the conventional difficulty in identifying the trend. The extraordinary axis points toward a void region, indicating the potential value of synthesizing novel solvents located therein.
Dinitrogen Functionalization with Carbon Dioxide and Carbon Disulfide Giving Symmetric and Unsymmetric Hydrazido Complexes
Authors: Ishida Yutaka , Hasegawa Sui , Kawaguchi Hiroyuki 
Published: June 2023

AbstractHere we show that a tridentate bis(aryloxide)anilide‐ligated titanium/potassium scaffold promotes functionalization of coordinated N2 with CO2 and CS2 through formation of N−C bonds. Treatment of a naphthalene complex with N2 gave an end‐on bridging dinitrogen complex featuring a [Ti2K2N2] core. The dinitrogen complex underwent insertion of CO2 into each Ti−NN bond to afford an N,N′‐dicarboxylated hydrazido complex. Stepwise nitrogen‐carbon bond formation at coordinated N2 proceeded to afford an unsymmetric hydrazido complex upon sequentially treating the dinitrogen complex with CS2 and CO2. Addition of Me3SiCl to the dicarboxylated hydrazido complex resulted in partial silylation of the carboxylate groups but did not lead to removal of the functionalized N2 unit from the metal centers. However, reduction of the dicarboxylated hydrazido complex with potassium naphthalenide afforded an oxo‐bridged dinuclear complex along with release of free potassium cyanate.
Diversification of Glycosyl Compounds via Glycosyl Radicals
Authors: Jiang Yi , Zhang Yijun , Lee Boon Chong , Koh Ming Joo 
Published: June 2023

AbstractGlycosyl radical functionalization is one of the central topics in synthetic carbohydrate chemistry. Recent advances in metal‐catalyzed cross‐coupling chemistry and metallaphotoredox catalysis provided powerful platforms for glycosyl radical diversification. In particular, the discovery of new glycosyl radical precursors in conjunction with these advanced reaction technologies have significantly expanded the space for glycosyl compound synthesis. In this Review, we highlight the most recent progress in this area starting from 2021, and the reports included will be categorized based on different reaction types for better clarity.
Framework‐Hotspot Enhanced Trans Cleavage of CRISPR‐Cas12a for Clinical Samples Detection
Authors: Li Fengqin , Li Junru , Yang Weiqiang , Yang Shuai , Chen Congshuo , Du Ling , Mei Junyang , Tang Qianyun , Chen Xiaojing , Yao Chi , Yang Dayong , Zuo Xiaolei , Liu Peifeng 
Published: June 2023

AbstractThe trans‐cleavage property of CRISPR‐Cas12a system makes it an excellent tool for disease diagnosis. Nevertheless, most methods based on CRISPR‐Cas system still require pre‐amplification of the target to achieve the desired detection sensitivity. Here we generate Framework‐Hotspot reporters (FHRs) with different local densities to investigate their effect on trans‐cleavage activity of Cas12a. We find that the cleavage efficiency increases and the cleavage rate accelerates with increasing reporter density. We further construct a modular sensing platform with CRISPR‐Cas12a‐based target recognition and FHR‐based signal transduction. Encouragingly, this modular platform enables sensitive (100 fM) and rapid (<15 min) detection of pathogen nucleic acids without pre‐amplification, as well as detection of tumor protein markers in clinical samples. The design provides a facile strategy for enhanced trans cleavage of Cas12a, which accelerates and broadens its applications in biosensing.
Bimetal‐Organic Framework Nanoboxes Enable Accelerated Redox Kinetics and Polysulfide Trapping for Lithium‐Sulfur Batteries
Authors: Zhu Zhuo , Zeng Yinxiang , Pei Zhihao , Luan Deyan , Wang Xin , Lou Xiong Wen (David) 
Published: June 2023

AbstractLithium‐sulfur (Li−S) batteries are considered as promising candidates for next‐generation energy storage systems in view of the high theoretical energy density and low cost of sulfur resources. The suppression of polysulfide diffusion and promotion of redox kinetics are the main challenges for Li−S batteries. Herein, we design and prepare a novel type of ZnCo‐based bimetallic metal–organic framework nanoboxes (ZnCo‐MOF NBs) to serve as a functional sulfur host for Li−S batteries. The hollow architecture of ZnCo‐MOF NBs can ensure fast charge transfer, improved sulfur utilization, and effective confinement of lithium polysulfides (LiPSs). The atomically dispersed Co−O4 sites in ZnCo‐MOF NBs can firmly capture LiPSs and electrocatalytically accelerate their conversion kinetics. Benefiting from the multiple structural advantages, the ZnCo‐MOF/S cathode shows high reversible capacity, impressive rate capability, and prolonged cycling performance for 300 cycles.
Solvation Structure with Enhanced Anionic Coordination for Stable Anodes in Lithium‐Oxygen Batteries
Authors: Huang Yaohui , Geng Jiarun , Jiang Zhuoliang , Ren Meng , Wen Bo , Chen Jun , Li Fujun 
Published: June 2023

AbstractLi‐O2 batteries have garnered much attention due to their high theoretical energy density. However, the irreversible lithium plating/stripping on the anode limits their performance, which has been paid little attention. Herein, a solvation‐regulated strategy for stable lithium anodes in tetraethylene glycol dimethyl ether (G4) based electrolyte is attempted in Li‐O2 batteries. Trifluoroacetate anions (TFA−) with strong Li+ affinity are incorporated into the lithium bis(fluorosulfonyl)imide (LiTFSI)/G4 electrolyte to attenuate the Li+‐G4 interaction and form anion‐dominant solvates. The bisalt electrolyte with 0.5 M LiTFA and 0.5 M LiTFSI mitigates G4 decomposition and induces an inorganic‐rich solid electrolyte interphase (SEI). This contributes to decreased desolvation energy barrier from 58.20 to 46.31 kJ mol−1, compared with 1.0 M LiTFSI/G4, for facile interfacial Li+ diffusion and high efficiency. It yields extended lifespan of 120 cycles in Li‐O2 battery with a limited Li anode (7 mAh cm−2). This work gains comprehensive insights into rational electrolyte design for Li‐O2 batteries.
A Cysteine‐Directed Proximity‐Driven Crosslinking Method for Native Peptide Bicyclization
Authors: Chen Fa‐Jie , Pinnette Nicole , Yang Fan , Gao Jianmin 
Published: June 2023

AbstractEfficient and site‐specific modification of native peptides and proteins is desirable for synthesizing antibody‐drug conjugates as well as for constructing chemically modified peptide libraries using genetically encoded platforms such as phage display. In particular, there is much interest in efficient multicyclization of native peptides due to the appeals of multicyclic peptides as therapeutics. However, conventional approaches for multicyclic peptide synthesis require orthogonal protecting groups or non‐proteinogenic clickable handles. Herein, we report a cysteine‐directed proximity‐driven strategy for the constructing bicyclic peptides from simple natural peptide precursors. This linear to bicycle transformation initiates with rapid cysteine labeling, which then triggers proximity‐driven amine‐selective cyclization. This bicyclization proceeds rapidly under physiologic conditions, yielding bicyclic peptides with a Cys‐Lys‐Cys, Lys‐Cys‐Lys or N‐terminus‐Cys‐Cys stapling pattern. We demonstrate the utility and power of this strategy by constructing bicyclic peptides fused to proteins as well as to the M13 phage, paving the way to phage display of novel bicyclic peptide libraries.
Dimeric Manganese‐Catalyzed Hydroalkenylation of Alkynes with a Versatile Silicon‐Based Directing Group
Authors: Pang Yubo , Chen Shuai , Han Jie , Zhu Chengjian , Zhao Chuan‐Gang , Xie Jin 
Published: June 2023

AbstractHerein, we present a manganese‐catalyzed, branched‐selective hydroalkenylation of terminal alkynes, under mild conditions through facile installation of a versatile silanol as a removable directing group. With an alkenyl boronic acid as the coupling partner, this reaction produces stereodefined (E,E)‐1,3‐dienes with high regio‐, chemo‐ and stereoselectivity. The protocol features mild reaction conditions such as room temperature and an air atmosphere, while maintaining excellent functional group compatibility. The resulting 1,3‐dienesilanol products serve as versatile building blocks, as the removal of the silanol group allows for the synthesis of both branched terminal 1,3‐dienes for downstream coupling reactions, as well as stereoselective construction of linear (E,E)‐1,3‐dienes and (E,E,E)‐ or (E,E,Z)‐1,3,5‐trienes. In addition, a Diels–Alder cycloaddition can smoothly and selectively deliver silicon‐containing pentasubstituted cyclohexene derivatives. Mechanistic investigations, in conjunction with DFT calculations, suggest a bimetallic synergistic activation model to account for the observed enhanced catalytic efficiency and good regioselectivity.
A Highly Accurate pH Detection Method for Sweat Analysis using a Printed 96‐Microwell Colorimetric Sensor Array
Authors: Sasaki Yui , Lyu Xiaojun , Minami Tsuyoshi 
Published: June 2023

AbstractInvited for this month's cover are is the collaborating group of Prof. Minami at The University of Tokyo. The cover picture shows a printed 96‐microwell paper‐based colorimetric sensor array to detect pH changes below the decimal point in human sweat. More information can be found in the Research Article by Yui Sasaki, Xiaojun Lyu, and Tsuyoshi Minami.
Synthesis and evaluation of multitarget new 2‐aminothiazole derivatives as potential anti‐Alzheimer's agents
Authors: Bardakkaya Merve , Kilic Burcu , Sagkan Rahsan Ilıkcı , Aksakal Fatma , Shakila Shakila , Dogruer Deniz S. 
Published: June 2023

AbstractIn this study, two diverse series of 2‐aminothiazole‐based multitarget compounds, one propenamide and the other propanamide derivatives, were designed and synthesized. Subsequently, their anticholinesterease and antioxidant (ORAC) activities were tested. Among them, compound 3e was the most potent acetylcholinesterase (AChE) inhibitor (AChE IC50 = 0.5 μM, butyrylcholinesterase [BChE] IC50 = 14.7 μM) and compound 9e was the most potent BChE inhibitor (AChE IC50 = 3.13 μM, BChE IC50 = 0.9 μM). Kinetic experiments showed that both compounds were mixed‐type inhibitors. According to the anticholinesterease activity results, five compounds (3e, 4e, 5e, 9d, and 9e) were selected for further activity studies, all of which are dual cholinesterase inhibitors. Then, selected compounds were investigated in terms of their metal chelation activity. Moreover, their neuroprotective effects against H2O2‐induced damage in the PC12 cell line were evaluated at 10 μM and the results showed that the neuroprotective effect of 3e was 53% compared with the reference ferulic acid (77%). 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) results of selected compounds revealed that the compounds were noncytotoxic. Additionally, 3e was more effective in reducing lipopolysaccharides‐induced interleukin‐1β (IL‐1β), IL‐6, tumor necrosis factor‐α (TNF‐α), and nitric oxide (NO) production in the human monocyte derived from patient with acute monocytic leukemia cell line compared with other selected compounds. Finally, a molecular docking study was also performed.