bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anger dysregulation and non-suicidal self-injury during adolescence: A test of directionality
Authors: Larsson Johannes , Tilton-Weaver Lauree C. , Zhao Xiang 
Published: July 2023

AbstractNon-suicidal self-injury (NSSI) has been tied to several forms of emotional and behavioral dysregulation in adolescence, with less attention paid to regulation of anger. Most assume that anger dysregulation leads to engagement in NSSI, rather than the reverse. However, it is plausible that NSSI compromises adolescents’ abilities to regulate their emotions, including anger, because it may reduce the development of alternative regulatory strategies and intensify negative emotions by reducing tolerance of distress. Using three waves of data from a sample of adolescents in 17 Swedish schools (n = 1,304 Mage = 13.68, SDage = .67; 89% of Swedish origin; 58% girls), we examined the directionality of ties between NSSI and three forms of anger dysregulation: dysregulated expressions of anger, anger suppression, and low anger reflection. We also looked for differences in magnitude of paths and gender differences. Random-intercept cross-lagged panel models showed that NSSI predicted changes in all forms of anger dysregulation but found no support for the opposite direction. Gender differences were not evident. Results challenge directionality assumptions and support suggestions that adolescents’ anger regulation degrades when they self-injure.
Solar‐Synchronous Tides in Mars Thermosphere CO2, Ar, and N2 Densities From MAVEN
Authors: Forbes Jeffrey M. , Zhang Xiaoli , Fang Xiaohua , Benna Mehdi , González‐Galindo Francisco , Forget Francois , Millour Ehouarn 
Published: July 2023

AbstractMeasurements of CO2, Ar and N2 densities from the Neutral Gas and Ion Mass Spectrometer on the Mars Atmosphere and Volatile Evolution Mission (MAVEN) between 150 and 200 km altitude during 2015–2022 are analyzed to reveal diurnal (DW1), semidiurnal (SW2) and terdiurnal (TW3) solar‐synchronous tides in Mars thermosphere. Multi‐year‐mean tidal perturbations on a diurnal‐ and zonal‐mean background, corrected for solar flux variations, are reported as a function of latitude (48°S–48°N), altitude and solar longitude (Ls). The DW1, SW2 and TW3 amplitudes at for example, 180 km altitude are of order 90%–120%, 15%–20%, and ≲10% for CO2 and Ar, and roughly 2/3 these values for N2, the latter presumably due to the difference in molecular weight from the other species. Through examination of vertical phase progressions, DW1 is concluded to be mainly excited in situ, but SW2 and TW3 contain significant contributions from tides propagating upward from lower altitudes. By analogy with studies for Earth's thermosphere, the DW1 amplitudes and phases are thought to reflect the combined influences of thermal expansion and vertical winds. Points of agreement and disagreement with DW1, SW2, and TW3 amplitudes and phases derived from the Mars Climate Database are noted and interpreted.
Controlling the electro-optic response of a semiconducting perovskite coupled to a phonon-resonant cavity
Authors: Di Virgilio Lucia , Geuchies Jaco J. , Kim Heejae , Krewer Keno , Wang Hai , Grechko Maksim , Bonn Mischa 
Published: July 2023

AbstractOptical cavities, resonant with vibrational or electronic transitions of material within the cavity, enable control of light-matter interaction. Previous studies have reported cavity-induced modifications of chemical reactivity, fluorescence, phase behavior, and charge transport. Here, we explore the effect of resonant cavity-phonon coupling on the transient photoconductivity in a hybrid organic-inorganic perovskite. To this end, we measure the ultrafast photoconductivity response of perovskite in a tunable Fabry–Pérot terahertz cavity, designed to be transparent for optical excitation. The terahertz-cavity field-phonon interaction causes apparent Rabi splitting between the perovskite phonon mode and the cavity mode. We explore whether the cavity-phonon interaction affects the material’s electron-phonon interaction by determining the charge-carrier mobility through photoconductivity. Despite the apparent hybridization of cavity and phonon modes, we show that the perovskite properties in both ground (phonon response) and excited (photoconductive response) states remain unaffected by the tunable light-matter interaction. Yet the response of the integral perovskite-terahertz optical cavity system depends critically on the interaction strength of the cavity with the phonon: the transient terahertz response to optical excitation can be increased up to threefold by tuning the cavity-perovskite interaction strength. These results enable tunable switches and frequency-controlled induced transparency devices.
In vivo evidence of microstructural hypo-connectivity of brain white matter in 22q11.2 deletion syndrome
Authors: Raven Erika P. , Veraart Jelle , Kievit Rogier A. , Genc Sila , Ward Isobel L. , Hall Jessica , Cunningham Adam , Doherty Joanne , van den Bree Marianne B. M. , Jones Derek K. 
Published: July 2023

Abstract22q11.2 deletion syndrome, or 22q11.2DS, is a genetic syndrome associated with high rates of schizophrenia and autism spectrum disorders, in addition to widespread structural and functional abnormalities throughout the brain. Experimental animal models have identified neuronal connectivity deficits, e.g., decreased axonal length and complexity of axonal branching, as a primary mechanism underlying atypical brain development in 22q11.2DS. However, it is still unclear whether deficits in axonal morphology can also be observed in people with 22q11.2DS. Here, we provide an unparalleled in vivo characterization of white matter microstructure in participants with 22q11.2DS (12–15 years) and those undergoing typical development (8–18 years) using a customized magnetic resonance imaging scanner which is sensitive to axonal morphology. A rich array of diffusion MRI metrics are extracted to present microstructural profiles of typical and atypical white matter development, and provide new evidence of connectivity differences in individuals with 22q11.2DS. A recent, large-scale consortium study of 22q11.2DS identified higher diffusion anisotropy and reduced overall diffusion mobility of water as hallmark microstructural alterations of white matter in individuals across a wide age range (6–52 years). We observed similar findings across the white matter tracts included in this study, in addition to identifying deficits in axonal morphology. This, in combination with reduced tract volume measurements, supports the hypothesis that abnormal microstructural connectivity in 22q11.2DS may be mediated by densely packed axons with disproportionately small diameters. Our findings provide insight into the in vivo white matter phenotype of 22q11.2DS, and promote the continued investigation of shared features in neurodevelopmental and psychiatric disorders.
Circulating metabolites modulated by diet are associated with depression
Authors: van der Spek Ashley , Stewart Isobel D. , Kühnel Brigitte , Pietzner Maik , Alshehri Tahani , Gauß Friederike , Hysi Pirro G. , MahmoudianDehkordi Siamak , Heinken Almut , Luik Annemarie I. , Ladwig Karl-Heinz , Kastenmüller Gabi , Menni Cristina , Hertel Johannes , Ikram M. Arfan , de Mutsert Renée , Suhre Karsten , Gieger Christian , Strauch Konstantin , Völzke Henry , Meitinger Thomas , Mangino Massimo , Flaquer Antonia , Waldenberger Melanie , Peters Annette , Thiele Ines , Kaddurah-Daouk Rima , Dunlop Boadie W. , Rosendaal Frits R. , Wareham Nicholas J. , Spector Tim D. , Kunze Sonja , Grabe Hans Jörgen , Mook-Kanamori Dennis O. , Langenberg Claudia , van Duijn Cornelia M. , Amin Najaf 
Published: July 2023

AbstractMetabolome reflects the interplay of genome and exposome at molecular level and thus can provide deep insights into the pathogenesis of a complex disease like major depression. To identify metabolites associated with depression we performed a metabolome-wide association analysis in 13,596 participants from five European population-based cohorts characterized for depression, and circulating metabolites using ultra high-performance liquid chromatography/tandem accurate mass spectrometry (UHPLC/MS/MS) based Metabolon platform. We tested 806 metabolites covering a wide range of biochemical processes including those involved in lipid, amino-acid, energy, carbohydrate, xenobiotic and vitamin metabolism for their association with depression. In a conservative model adjusting for life style factors and cardiovascular and antidepressant medication use we identified 8 metabolites, including 6 novel, significantly associated with depression. In individuals with depression, increased levels of retinol (vitamin A), 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1) (lecithin) and mannitol/sorbitol and lower levels of hippurate, 4-hydroxycoumarin, 2-aminooctanoate (alpha-aminocaprylic acid), 10-undecenoate (11:1n1) (undecylenic acid), 1-linoleoyl-GPA (18:2) (lysophosphatidic acid; LPA 18:2) are observed. These metabolites are either directly food derived or are products of host and gut microbial metabolism of food-derived products. Our Mendelian randomization analysis suggests that low hippurate levels may be in the causal pathway leading towards depression. Our findings highlight putative actionable targets for depression prevention that are easily modifiable through diet interventions.
Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies
Authors: Finze Anika , Biechele Gloria , Rauchmann Boris-Stephan , Franzmeier Nicolai , Palleis Carla , Katzdobler Sabrina , Weidinger Endy , Guersel Selim , Schuster Sebastian , Harris Stefanie , Schmitt Julia , Beyer Leonie , Gnörich Johannes , Lindner Simon , Albert Nathalie L. , Wetzel Christian H. , Rupprecht Rainer , Rominger Axel , Danek Adrian , Burow Lena , Kurz Carolin , Tato Maia , Utecht Julia , Papazov Boris , Zaganjori Mirlind , Trappmann Lena-Katharina , Goldhardt Oliver , Grimmer Timo , Haeckert Jan , Janowitz Daniel , Buerger Katharina , Keeser Daniel , Stoecklein Sophia , Dietrich Olaf , Morenas-Rodriguez Estrella , Barthel Henryk , Sabri Osama , Bartenstein Peter , Simons Mikael , Haass Christian , Höglinger Günter U. , Levin Johannes , Perneczky Robert , Brendel Matthias 
Published: July 2023

Abstractβ-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer’s disease (AD), and biomarkers for these hallmarks have been linked to neuroinflammation. However, the detailed regional associations of these biomarkers with microglial activation in individual patients remain to be elucidated. We investigated a cohort of 55 patients with AD and primary tauopathies and 10 healthy controls that underwent TSPO-, Aβ-, tau-, and perfusion-surrogate-PET, as well as structural MRI. Z-score deviations for 246 brain regions were calculated and biomarker contributions of Aβ (A), tau (T), perfusion (N1), and gray matter atrophy (N2) to microglial activation (TSPO, I) were calculated for each individual subject. Individual ATN-related microglial activation was correlated with clinical performance and CSF soluble TREM2 (sTREM2) concentrations. In typical and atypical AD, regional tau was stronger and more frequently associated with microglial activation when compared to regional Aβ (AD: βT = 0.412 ± 0.196 vs. βA = 0.142 ± 0.123, p < 0.001; AD-CBS: βT = 0.385 ± 0.176 vs. βA = 0.131 ± 0.186, p = 0.031). The strong association between regional tau and microglia reproduced well in primary tauopathies (βT = 0.418 ± 0.154). Stronger individual associations between tau and microglial activation were associated with poorer clinical performance. In patients with 4RT, sTREM2 levels showed a positive association with tau-related microglial activation. Tau pathology has strong regional associations with microglial activation in primary and secondary tauopathies. Tau and Aβ related microglial response indices may serve as a two-dimensional in vivo assessment of neuroinflammation in neurodegenerative diseases.
Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication
Authors: Ye Fangzhou , Liang Yiran , Wang Yajie , Le Yang Robert , Luo Dan , Li Yaming , Jin Yuhan , Han Dianwen , Chen Bing , Zhao Wenjing , Wang Lijuan , Chen Xi , Ma Tingting , Kong Xiaoli , Yang Qifeng 
Published: July 2023

AbstractBreast cancer is the major common malignancy worldwide among women. Previous studies reported that cancer-associated fibroblasts (CAFs) showed pivotal roles in regulating tumor progression via exosome-mediated cellular communication. However, the detailed mechanism underlying the exosomal circRNA from CAFs in breast cancer progression remains ambiguous. Here, exosomal circRNA profiling of breast cancer-derived CAFs and normal fibroblasts (NFs) was detected by high-throughput sequencing, and upregulated circTBPL1 expression was identified in CAF exosomes. The exosomal circTBPL1 from CAFs could be transferred to breast cancer cells and promoted cell proliferation, migration, and invasion. Consistently, circTBPL1 knockdown in CAFs attenuated their tumor-promoting ability. Further exploration identified miR-653-5p as an inhibitory target of circTBPL1, and ectopic expression of miR-653-5p could partially reverse the malignant phenotypes induced by circTBPL1 overexpression in breast cancer. Additionally, TPBG was selected as a downstream target gene, and circTBPL1 could protect TPBG from miR-653-5p-mediated degradation, leading to enhanced breast cancer progression. Significantly, the accelerated tumor progression triggered by exosomal circTBPL1 from CAFs was confirmed in xenograft models. Taken together, these results revealed that exosomal circTBPL1 derived from CAFs contributed to cancer progression via miR-653-5p/TPBG pathway, indicating the potential of exosomal circTBPL1 as a biomarker and novel therapeutic target for breast cancer.
Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
Authors: Ryder Laura , Arendrup Frederic Schrøder , Martínez José Francisco , Snieckute Goda , Pecorari Chiara , Shah Riyaz Ahmad , Lund Anders H. , Blasius Melanie , Bekker-Jensen Simon 
Published: July 2023

AbstractImpairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and rescue pathways. Despite clear evidence that ribosome collision occurs stochastically at a cellular and organismal level, physiologically relevant sources of such aberrations are poorly understood. Here we show that a burst of the cellular signaling molecule nitric oxide (NO) reduces translational activity and causes ribosome collision in human cell lines. This is accompanied by activation of the ribotoxic stress response, resulting in ZAKα-mediated activation of p38 and JNK kinases. In addition, NO production is associated with ZNF598-mediated ubiquitination of the ribosomal protein RPS10 and GCN2-mediated activation of the integrated stress response, which are well-described responses to the collision of ribosomes. In sum, our work implicates a novel role of NO as an inducer of ribosome collision and activation of ribosomal surveillance mechanisms in human cells.
Cysteines 1078 and 2991 cross-linking plays a critical role in redox regulation of cardiac ryanodine receptor (RyR)
Authors: Nikolaienko Roman , Bovo Elisa , Kahn Daniel , Gracia Ryan , Jamrozik Thomas , Zima Aleksey V. 
Published: July 2023

AbstractThe most common cardiac pathologies, such as myocardial infarction and heart failure, are associated with oxidative stress. Oxidation of the cardiac ryanodine receptor (RyR2) Ca2+ channel causes spontaneous oscillations of intracellular Ca2+, resulting in contractile dysfunction and arrhythmias. RyR2 oxidation promotes the formation of disulfide bonds between two cysteines on neighboring RyR2 subunits, known as intersubunit cross-linking. However, the large number of cysteines in RyR2 has been a major hurdle in identifying the specific cysteines involved in this pathology-linked post-translational modification of the channel. Through mutagenesis of human RyR2 and in-cell Ca2+ imaging, we identify that only two cysteines (out of 89) in each RyR2 subunit are responsible for half of the channel’s functional response to oxidative stress. Our results identify cysteines 1078 and 2991 as a redox-sensitive pair that forms an intersubunit disulfide bond between neighboring RyR2 subunits during oxidative stress, resulting in a pathological “leaky” RyR2 Ca2+ channel.
Enhancing polyol/sugar cascade oxidation to formic acid with defect rich MnO2 catalysts
Authors: Yan Hao , Liu Bowen , Zhou Xin , Meng Fanyu , Zhao Mingyue , Pan Yue , Li Jie , Wu Yining , Zhao Hui , Liu Yibin , Chen Xiaobo , Li Lina , Feng Xiang , Chen De , Shan Honghong , Yang Chaohe , Yan Ning 
Published: July 2023

AbstractOxidation of renewable polyol/sugar into formic acid using molecular O2over heterogeneous catalysts is still challenging due to the insufficient activation of both O2and organic substrates on coordination-saturated metal oxides. In this study, we develop a defective MnO2catalyst through a coordination number reduction strategy to enhance the aerobic oxidation of various polyols/sugars to formic acid. Compared to common MnO2, the tri-coordinated Mn in the defective MnO2catalyst displays the electronic reconstruction of surface oxygen charge state and rich surface oxygen vacancies. These oxygen vacancies create more Mnδ+Lewis acid site together with nearby oxygen as Lewis base sites. This combined structure behaves much like Frustrated Lewis pairs, serving to facilitate the activation of O2, as well as C–C and C–H bonds. As a result, the defective MnO2catalyst shows high catalytic activity (turnover frequency: 113.5 h−1) and formic acid yield (>80%) comparable to noble metal catalysts for glycerol oxidation. The catalytic system is further extended to the oxidation of other polyols/sugars to formic acid with excellent catalytic performance.
Accelerating the energy transition towards photovoltaic and wind in China
Authors: Wang Yijing , Wang Rong , Tanaka Katsumasa , Ciais Philippe , Penuelas Josep , Balkanski Yves , Sardans Jordi , Hauglustaine Didier , Liu Wang , Xing Xiaofan , Li Jiarong , Xu Siqing , Xiong Yuankang , Yang Ruipu , Cao Junji , Chen Jianmin , Wang Lin , Tang Xu , Zhang Renhe 
Published: July 2023

AbstractChina’s goal to achieve carbon (C) neutrality by 2060 requires scaling up photovoltaic (PV) and wind power from 1 to 10–15 PWh year−1(refs. 1–5). Following the historical rates of renewable installation1, a recent high-resolution energy-system model6and forecasts based on China’s 14th Five-year Energy Development (CFED)7, however, only indicate that the capacity will reach 5–9.5 PWh year−1by 2060. Here we show that, by individually optimizing the deployment of 3,844 new utility-scale PV and wind power plants coordinated with ultra-high-voltage (UHV) transmission and energy storage and accounting for power-load flexibility and learning dynamics, the capacity of PV and wind power can be increased from 9 PWh year−1(corresponding to the CFED path) to 15 PWh year−1, accompanied by a reduction in the average abatement cost from US$97 to US$6 per tonne of carbon dioxide (tCO2). To achieve this, annualized investment in PV and wind power should ramp up from US$77 billion in 2020 (current level) to US$127 billion in the 2020s and further to US$426 billion year−1in the 2050s. The large-scale deployment of PV and wind power increases income for residents in the poorest regions as co-benefits. Our results highlight the importance of upgrading power systems by building energy storage, expanding transmission capacity and adjusting power load at the demand side to reduce the economic cost of deploying PV and wind power to achieve carbon neutrality in China.
Evolutionary histories of breast cancer and related clones
Authors: Nishimura Tomomi , Kakiuchi Nobuyuki , Yoshida Kenichi , Sakurai Takaki , Kataoka Tatsuki R. , Kondoh Eiji , Chigusa Yoshitsugu , Kawai Masahiko , Sawada Morio , Inoue Takuya , Takeuchi Yasuhide , Maeda Hirona , Baba Satoko , Shiozawa Yusuke , Saiki Ryunosuke , Nakagawa Masahiro M. , Nannya Yasuhito , Ochi Yotaro , Hirano Tomonori , Nakagawa Tomoe , Inagaki-Kawata Yukiko , Aoki Kosuke , Hirata Masahiro , Nanki Kosaku , Matano Mami , Saito Megumu , Suzuki Eiji , Takada Masahiro , Kawashima Masahiro , Kawaguchi Kosuke , Chiba Kenichi , Shiraishi Yuichi , Takita Junko , Miyano Satoru , Mandai Masaki , Sato Toshiro , Takeuchi Kengo , Haga Hironori , Toi Masakazu , Ogawa Seishi 
Published: July 2023

AbstractRecent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated in cancer development1–3. However, our knowledge is still missing with regard to what additional driver events take place in what order, before one or more of these clones in normal tissues ultimately evolve to cancer. Here, using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, we show unique evolutionary histories of breast cancers harbouring der(1;16), a common driver alteration found in roughly 20% of breast cancers. The approximate timing of early evolutionary events was estimated from the mutation rate measured in normal epithelial cells. In der(1;16)(+) cancers, the derivative chromosome was acquired from early puberty to late adolescence, followed by the emergence of a common ancestor by the patient’s early 30s, from which both cancer and non-cancer clones evolved. Replacing the pre-existing mammary epithelium in the following years, these clones occupied a large area within the premenopausal breast tissues by the time of cancer diagnosis. Evolution of multiple independent cancer founders from the non-cancer ancestors was common, contributing to intratumour heterogeneity. The number of driver events did not correlate with histology, suggesting the role of local microenvironments and/or epigenetic driver events. A similar evolutionary pattern was also observed in another case evolving from an AKT1-mutated founder. Taken together, our findings provide new insight into how breast cancer evolves.