bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a Rational Design of Antibody‐Recruiting Molecules through a Computational Microscopy View of their Interactions with the Target Antibody
Authors: Uvyn Annemiek , Tonneaux Corentin , Fossépré Mathieu , Ouvrier‐Buffet Aude , De Geest Bruno G. , Surin Mathieu 
Published: March 2023

AbstractAntibody recruiting molecules (ARMs) are an innovative class of chimeric molecules, consisting of an antibody‐binding ligand (ABL) and a target‐binding ligand (TBL). ARMs mediate ternary complex formation between a target cell of interest for elimination and endogenous antibodies that are present in human serum. Clustering of fragment crystallizable (Fc) domains on the surface of antibody‐bound cells mediate destruction of the target cell by innate immune effector mechanisms. ARMs are typically designed by conjugating small molecule haptens to a (macro)molecular scaffold, without considering the structure of the respective anti‐hapten antibody. Here we report on a computational molecular modeling methodology that allows for studying the close contacts between ARMs and the anti‐hapten antibody, considering (1) the spacer length between ABL and TBL; (2) the number of ABL and TBL, and (3) the molecular scaffold onto which these are positioned. Our model predicts the difference in binding modes of the ternary complex and predicts which ARMs are optimal recruiters. Avidity measurements of the ARM‐antibody complex and ARM‐mediated antibody recruitment to cell surfaces in vitro confirmed these computational modeling predictions. This kind of multiscale molecular modelling holds potential for design of drug molecules that rely on antibody binding for their mechanism of action.
Attachment, motivational systems and anorexia nervosa: A systematic review and proposed framework for eating disorders
Authors: Budia José Miguel , Alcover Carlos María , Fernández‐Muñoz Juan José , Blanco‐Fernández Ascensión , Félix‐Alcántara Miriam P. 
Published: March 2023

AbstractIntroductionThere is a direct association between patients with insecure attachment style (IAS), behavioural inhibition (BIS) and behavioural activation (BAS) motivational systems, and anorexia nervosa (AN). However, the possible direct relationships between these three variables have not been studied.ObjectiveThe main objective of this study is to analyse the relationship between these variables and propose a framework for analysing and understanding these relationships.MethodologyA systematic review was carried out following the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines, searching the following terms: ‘anorexia’, ‘attachment’ and those related to motivational systems. The final search was limited to publications in English dated between 2014–2022 for ‘anorexia and attachment’ and 2010–2022 for ‘anorexia and BIS/BAS’.ResultsOf the 587 articles retrieved, 30 were included in this study for the textual data analysis of the relationship between anorexia and attachment (17), anorexia and motivational systems (10) and anorexia, attachment and motivational systems (3). An association between avoidant IAS, AN and hypersensitivity to punishment of the BIS was observed in the analysis. A relationship was also observed with hyperreinforcement sensitivity of the BAS. After reviewing the articles, a possible relationship between the three factors, along with other mediating factors, was found.DiscussionAN is directly related to the avoidant IAS and to BIS. Similarly, bulimia nervosa (BN) was directly related with anxious IAS and BAS. However, contradictions were found in the BN–BAS relationship. This study proposes a framework for analysing and understanding these relationships.
Comprehensive review of battery charger structures of EVs and HEVs for levels 1–3
Authors: Berrehil El Kattel Menaouar , Mayer Robson , Ely Fernando , de Jesus Cardoso Filho Braz 
Published: March 2023

SummaryAs battery electric vehicles (BEVs), plug‐in hybrid electric vehicles (PHEVs), and hybrid electric vehicles (HEVs) gain popularity among the consumers, current research initiatives are targeted at developing battery charger structures that can exploit utility power to charge vehicle batteries and thus less dependent on fuel usage. This paper reviews the state of the art and implementation of battery charger structures, charger power levels, and the evolution of publications on electric vehicles in the digital libraries and Espacenet patent base. Charger systems addressed are categorized as a structure with a non‐isolated alternating current (AC)–direct current (DC) stage, structure with an isolated AC–DC stage, and structure with two non‐isolated stages. Advantages and disadvantages of each conductive battery charging structure have been discussed due to weight, volume, cost, necessary equipment, the complexity of topologies, and other factors. In addition, both off‐board and on‐board charger systems with unidirectional or bidirectional power flow are presented. Several electronic converters for power‐level chargers are being developed to allow plug‐in vehicles to be capable of vehicle to grid (V2G), where they can function as distributed resources and power can be returned to the grid.
Color, pH, microbiological, and sensory quality of crickets (Gryllus bimaculatus) flour preserved with ginger and garlic extracts
Authors: Akullo Jolly Oder , Kiage‐Mokua Beatrice N. , Nakimbugwe Dorothy , Ng'ang'a Jeremiah , Kinyuru John 
Published: March 2023

AbstractAlthough spices have been used in food for centuries, little is known about their use to preserve insect‐based foods. This study assessed the flour produced from blanched crickets treated with extracts of either ginger, garlic or both at a ratio of 1:4 (v/w) for color, pH, microbiological profile, sensory quality, and acceptability. Sodium benzoate treated and untreated cricket flour was used as positive and negative controls, respectively. The flour was stored at ambient conditions and analyzed on 0, 30, and 60 days of storage. The pH, moisture content and color change increased during storage but remained within acceptable limits. The total microbial count, yeast and molds significantly decreased with storage duration (p ˂ .05), while fecal coliforms and Escherichia coli were not detected in any of the samples. At the end of the 60‐day storage period, cricket flour treated with sodium benzoate and garlic extracts both had a significantly lowest population of yeast and molds (1.91 log cfu/g). On five point hedonic scale (1. Dislike extremely and 5. Like extremely), color (3.84 ± 0.86–2.55 ± 0.99), aroma (3.59 ± 1.09–2.40 ± 1.01), texture (4.11 ± 0.97–3.11 ± 0.97) and overall acceptability (3.77 ± 0.64–2.83 ± 1.01) sensory scores were all significantly high on day 0 and low on day 60 of storage, respectively. The study concluded that preserving crickets with garlic extracts significantly reduced the population of yeast and molds. Cricket flours were microbiologically safe and acceptable to consumers. Therefore, storage of cricket flour preserved with garlic and ginger extracts for longer periods is recommended. In addition, utilization of the preserved flour as an ingredient in different food applications is recommended to determine its suitability and sensory acceptability.
The quality of systematic reviews/meta‐analyses assessing the effects of ankle–foot orthosis on clinical outcomes in stroke patients: A methodological systematic review
Authors: Shahabi Saeed , Mojgani Parviz , Lankarani Kamran Bagheri , Jalali Maryam 
Published: March 2023

AbstractBackground and AimsGiven the importance of systematic reviews (SRs) for practitioners, researchers, and policymakers, it is essential to assess them to ensure robust methodology and reliable results before applying them. The purpose of this methodological study was to assess the methodological and reporting quality of recently published SRs and/or meta‐analyses (MAs) evaluating the effects of ankle–foot orthoses (AFOs) on clinical outcomes in stroke survivors.MethodsPubMed, Scopus, Web of Science, Embase, ProQuest, CENTRAL, REHABDATA, and PEDro were searched. The research team applied A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR‐2) tool and Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) checklist for evaluating the reporting and methodological quality, respectively, and the ROBIS tool was used to evaluate the risk of bias (RoB) in the included reviews. The quality of the evidence was also judged using the (Grades of Recommendation, Assessment, Development and Evaluation) GRADE method.ResultsIn final, 14 SRs/MAs met inclusion criteria. Evaluation of methodological quality using the AMSTAR‐2 tool demonstrated that the overall quality of included reviews was mostly “critically low” or “low,” except for two studies that were “high.” In addition, the findings showed that the mean score of the reporting quality of the included reviews based on the PRISMA criteria was 24.9, down from 42. In accordance with the overall evaluation applying the ROBIS tool, 14.3% of the review studies were evaluated as high RoB, 64.3% were evaluated as unclear RoB, and 21.4% were evaluated as low RoB. Regarding the level of evidence quality, the GRADE results indicated that the evidence quality of the included reviews was unsatisfactory.ConclusionThis study showed that although the reporting quality of recently published SR/MAs evaluating the clinical effects of AFOs in stroke survivors was moderate, the methodological quality of almost all reviews was suboptimal. Therefore, reviewers must consider a number of criteria in designing, conducting, and reporting their studies to move toward transparent and conclusive results.
Medication therapy problems assessment within medication history objective structured clinical examinations using standardized patients versus peer actors
Authors: Boylan Paul M. , Skrepnek Grant H. , Neely Stephen 
Published: March 2023

AbstractIntroductionStandardized patients (SPs) are actors who role‐play patients in objective structured clinical examinations (OSCEs). Potential benefits of using SPs may include standardized learning experiences and realistic emulations. Use of SPs on academic performance remains unreported.ObjectiveTo compare students' identification of medication therapy problems (MTPs) in medication history OSCEs utilizing SPs versus those utilizing student peer actors.MethodsThis single‐center historical cohort study included two cohorts of third‐year student pharmacists in a capstone course in spring 2019 and 2021. One cohort had peers acting as patients and another interacted with SPs. Students completed two OSCEs and were assessed by faculty using a performance‐based rubric. Outcomes included students' identification of MTPs defined per Pharmacy Quality Alliance Frameworks, OSCE performance, levels of MTP management, and questionnaire item responses.ResultsOne‐hundred forty‐three subjects were enrolled: 86 in the peer and 57 in the SP cohorts. Baseline characteristics between cohorts were similar across age, overall grade point average, and composite Pharmacy College Admission Test score. Fewer students in the SP cohort identified MTPs versus the peer actor cohort on both OSCEs (52.6% vs. 89.7%, p < 0.001, and 64.9% vs. 88.2%, p = 0.001), and OSCE grades were significantly lower in the SP cohort (76.0% vs. 81.5%, p = 0.01, and 76.5% vs. 89.0%, p < 0.001). Medication therapy problem management was significantly different between the cohorts across both OSCEs (p < 0.05). Students responded to questionnaire items by agreeing SPs were effective and improved the OSCEs.ConclusionUse of SPs in medication history OSCEs was associated with significant decreases in students' identification of MTPs and lower OSCE grades. Continued research is warranted to assess factors associated with differences in performance and to provide recommendations optimizing SP and peer actor roles.
MicroRNA‐143‐3p ameliorates collagen‐induced arthritis by polarizing naive CD4+T cells into Treg cells
Authors: Shen Mei‐Yu , Jiang Bao‐Ping , Zhang Ming‐Fei , Wang Xiang , Zhu Hong , Gu Zhen‐Ning , Zhou Xue‐Ping , Lu Yan , Zhou Ling‐Ling 
Published: March 2023

AbstractBackgroundRheumatoid arthritis (RA) is a persistent and systemic autoimmunity disease. The abnormal differentiation of Treg cells is important in pathogenesis. Despite previous studies showed that microRNAs (miRNAs, miR) are pivotal modulators of Treg cells, the effect of miRNAs on Treg cell differentiation and function is not clear. Our study wants to reveal the relationship of miR‐143‐3p with the differentiative ability and biofunction of Treg cells during the development of RA.MethodsThe Expressing level of miR‐143‐3p and cell factor generation in peripheral blood (PB) of RA sufferers were identified by ELISA or RT‐qPCR. The roles of miR‐143‐3p in Treg cell differentiation were studied via ShRNA/lentivirus transfection. Male DBA/1 J mice were separated into control, model, control mimics, and miR‐143‐3p mimics groups to analyze the anti‐arthritis efficacy, the differentiative ability of Treg cells, and the expression level of miR‐143‐3p.ResultsOur team discovered that the Expressing level of miR‐143‐3p was related to RA disease activities in a negative manner, and remarkably related to antiinflammation cell factor IL‐10. In vitro, the expression of miR‐143‐3p in the CD4+T cells upregulated the percentage of CD4+CD25+Fxop3+ cells (Tregs) and forkhead box protein 3 (Foxp3) mRNA expression. Evidently, miR‐143‐3p mimic intervention considerably upregulated the content of Treg cells in vivo, validly avoided CIA progression, and remarkably suppressed the inflammatory events of joints in mice.ConclusionOur findings indicated that miR‐143‐3p could ameliorate CIA through polarizing naive CD4+T cells into Treg cells, which may be a novel strategy to treat autoimmune diseases such as RA.
Inhibition of iron chelate degradation in liquid redox desulfurization by nanoscale MnO2 through H2O2 decomposition
Authors: Wang Jianhong , Jing Yuhe 
Published: March 2023

AbstractBACKGROUNDSignificant operating costs incurred in the liquid‐phase oxidation process using iron chelate catalytic solution (e.g. LO‐CAT) due to degradation and eventual loss of the iron chelate is a serious deficiency. Hydroxyl radicals formed in the Fenton reaction of ferrous chelate with H2O2, generated during the regeneration of the ferrous chelate with air, are responsible for iron chelate degradation. Although iron chelate degradation may be slowed down or inhibited by the catalytic decomposition of H2O2 into O2 and H2O, what is not yet clear is the impact of H2O2 decomposition by MnO2 on iron chelate degradation. In this work, the effects of H2O2 concentration, MnO2 concentration, oxygen as well as the initial pH value on iron chelate degradation in alkaline Fenton system of Fe2+‐EDTA/H2O2 (where EDTA is ethylenediaminetetraacetic acid) were studied.RESULTSResults showed that the percentage degradation of Fe‐EDTA increased with H2O2 concentration and decreased with H2O2 decomposition. In contrast to commercial MnO2, nanoscale MnO2 had much excellent catalytic activity on the decomposition of H2O2; thus 60 mmol L−1 nanoscale MnO2 inhibited Fe‐EDTA degradation by up to 82%. Furthermore, the inhibition in Fe‐EDTA degradation by H2O2 decomposition on nanoscale MnO2 was independent of pH from 6.0 to 8.5, and was related to oxygen concentration.CONCLUSIONNanoscale MnO2 can effectively inhibit the iron chelate degradation in LO‐CAT, and the significant operational costs associated with iron chelate degradation will be reduced by H2O2 decomposition on recyclable nanoscale MnO2 catalysts. © 2023 Society of Chemical Industry (SCI).
Associations among psychosis, mood, anxiety, and posttraumatic stress symptoms: A network analysis
Authors: Astill Wright Laurence , McElroy Eoin , Barawi Kali , Roberts Neil P , Simon Natalie , Zammit Stanley , Bisson Jonathan I 
Published: March 2023

AbstractThe associations among psychotic experiences (i.e., hallucinations and delusions), trauma exposure, and posttraumatic stress symptoms are complex and multidirectional. Using network analysis to understand how psychotic experiences and symptoms of posttraumatic stress disorder (PTSD) relate to one another may identify new interventional targets to treat comorbidity and its underlying pathological processes. This study aimed to use network analysis to examine the associations among psychotic experiences; negative symptoms of psychosis; and symptoms of PTSD, anxiety, and depression. In this population‐based cohort study, 4,472 participants (36.7% male) were assessed for psychotic experiences, negative symptoms of psychosis, PTSD, anxiety, and depression at age 23 (M= 23.86 years,SD= 0.520) or 24 years (M= 24.03,SD= 0.848). Associations among symptoms were assessed via network analysis. Exploratory graph analysis identified three clusters of densely connected symptoms within the overall network: psychotic experiences; PTSD symptoms; and depressive and anxiety symptoms and negative symptoms of psychosis. Psychotic experiences had the strongest associations with other symptoms in the network, and symptoms of anxiety played a key role in bridging psychotic experiences, symptoms of PTSD, and depressive symptoms. Consistent with the stress reactivity and affective models for psychotic experiences, the results suggest that symptoms of anxiety and emotional distress (e.g., hyperarousal, panic) may have a key role in the development and maintenance of psychotic experiences and symptoms of PTSD. Targeting these symptoms may ameliorate symptom burden transdiagnostically.
Averaging principle for stochastic quasi‐geostrophic flow equation with a fast oscillation
Authors: Chen Guanggan , Wang Pin 
Published: March 2023

AbstractThis work is focused on the quasi‐geostrophic flow equation with a fast oscillation governed by a stochastic reaction–diffusion equation. It derives the well‐posedness of the slow–fast system, in which the fast component is ergodic and the slow component is tight. Applying the averaging principle, it is further proved that there exists a limit process, with respect to the singular perturbing parameter ε, where the fast component is averaged out. Moreover, the slow component of the slow–fast system converges to the solution of the averaged equation in some strong sense as ε tends to zero.
H∞‐optimal observer design for systems with multiple delays in states, inputs and outputs: A PIE approach
Authors: Wu Shuangshuang , Peet Matthew M. , Sun Fuchun , Hua Changchun 
Published: March 2023

AbstractThis article investigates the ‐optimal estimation problem of a class of linear system with delays in states, disturbance input, and outputs. The estimator uses an extended Luenberger estimator format which estimates both the present and history states. The estimator is designed using an equivalent Partial Integral Equation (PIE) representation of the coupled nominal system. The advantage of the resulting PIE representation is compact and delay free—obviating the need for commonly used bounding technique such as integral inequalities which typically introduces conservatism into the resulting optimization problem. The ‐optimal estimator synthesis problem is then reformulated as a Linear Partial Inequality (LPI)—a form of convex optimization using operator variables and inequlities. Such LPI‐based optimization problems can be solved using semidefinite programming via the PIETOOLS toolbox in Matlab. Compared with previous work, the proposed method simplifies the analysis and computation process and resulting in observers which are non‐conservtism to 4 decimal places when compared with Pad‐based ODE observer design methodologies. Numerical examples and simulation results are given to illustrate the effectiveness and scalability of the proposed approach.
The Passport as a Medium of Movement
Authors: Lehmuskallio Asko , Haara Paula 
Published: March 2023

AbstractPassports are integral for bodies to move across borders and enable decisions on who is allowed to pass through ports and who has to stay within specific jurisdictional areas. In the nineteenth century, passport documents were still mainly letters of reference, indicating the importance of the issuer. Only later, and increasingly since the First World War, they also became a means of identification. Today, identification in electronic form is key for passport development, which is why centralised and widely standardised registers such as the Finnish Population Information System have become obligatory points of passage for passport development. In this paper, based on empirical research in Finnish archives, museums and among passport developers, we identify four regimes within the history of Finnish passports that all rely on distinct modes of cooperation among applicants, issuers, registers and border officials. While in the nineteenth century passport holders had significant agency in negotiating who they were at border crossings, slowly but surely the ability for a physical body to speak for itself has diminished. Instead, over time, centralised registers were built, which need to be continually updated before any changes in passport documentation can be made. Today, the body is read and deciphered, increasingly with automated means, and the results need to match the information found in electronic form. The passport, as a medium of movement, is only temporarily stabilized for a limited period of time. It is continually modified and developed as the infrastructures for supporting and inhibiting human movement change. Different passport regimes are therefore tied to different modes of cooperation, and only their description allows us to gain an understanding of passports as a medium of movement.
High energy resummed predictions for the production of a Higgs boson with at least one jet
Authors: Andersen Jeppe R. , Hassan Hitham , Maier Andreas , Paltrinieri Jérémy , Papaefstathiou Andreas , Smillie Jennifer M. 
Published: March 2023

Abstract
We present all-order predictions for Higgs boson production plus at least one jet which are accurate to leading logarithm in $$ \hat{s}/{\left|{p}_{\perp}\right|}^2 $$

s
̂

/

p
⊥

2

. Our calculation includes full top and bottom quark mass dependence at all orders in the logarithmic part, and to highest available order in the tree-level matching. The calculation is implemented in the framework of High Energy Jets (HEJ). This is the first cross section calculated with log($$ \hat{s} $$

s
̂

) resummation and matched to fixed order for a process requiring just one jet, and our results also extend the region of resummation for processes with two jets or more. This is possible because the resummation is performed explicitly in phase space. We compare the results of our new calculation to LHC data and to next-to-leading order predictions and find a numerically significant impact of the logarithmic corrections in the shape of key distributions, which remains after normalisation of the cross section.