bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with Nasal Hyperreactivity Among Asthmatic Patients in Kinshasa, Democratic Republic of Congo: A Cross-Sectional Study
Authors: Mpiana Sympho J. , Bosonkie Marc M. , Kabengele Bénoit O. , Mbunga Branly K. , Kayembe Jean-Marie N. , Nyembue Dieudonné T. 
Published: September 2023

AbstractNasal hyperreactivity (NHR) represents a new phenotype of rhinitis that is less known. Data about the frequency of NHR among people with asthma as well as the nature of the triggers are lacking in our setting. Therefore, we aimed to determine the frequency and factors associated with NHR among Congolese asthmatic patients. From February 2020 to April 2021, we carried out a cross-sectional study among asthmatic outpatients who attended the Otorhinolaryngology and Pneumology Departments of the University Hospital of Kinshasa. Sociodemographic, environmental, clinical, biological, and therapeutic variables were evaluated. Of 152 asthmatic outpatients, 53.3% had NHR (112 females). The average age was 45.8 ± 18.3 years, with predominance of people aged between 18 and 45 years. Allergic rhinitis (67.1%) was the most reported comorbidity. Nasal symptomatology was dominated by sneezing (79.6%), stuffy nose (78.9%) and runny nose (68.4%). Dyspnea (86.2%), cough (74.3%) and shortness of breath (74.3%) were the most frequent pulmonary symptoms. The number of nasal stimuli, a change in temperature (humidity) and physical exertion were the main factors associated with NHR in this study. NHR is frequent among asthmatic patients. Studies on the impact of NHR on the control of asthma and bronchial hyperreactivity are needed.
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer
Authors: Kao Hung-Ying , Pai Chun-Peng , Wang Han , Agarwal Neel , Adams Joshua , Liu Zhenghao , Seachrist Darcie , Keri Ruth , Schiemann William 
Published: September 2023

Abstract
The alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. PML depletion reduces cell proliferation, invasion, and stemness, while heterologous PML1 expression augments these processes and fuels tumor growth and resistance to fulvestrant, an FDA-approved drug for ER + breast cancer, in a mouse model. Moreover, PML1, rather than the well-known tumor suppressor isoform PML4, rescues the proliferation of PML knockdown cells. ChIP-seq analysis reveals significant overlap between PML-, ER-, and Myc-bound promoters, suggesting their coordinated regulation of target gene expression, including genes involved in breast cancer stem cells (BCSCs), such as JAG1, KLF4, YAP1, SNAI1, and MYC. Loss of PML reduces BCSC-related gene expression, and exogenous PML1 expression elevates their expression. Consistently, PML1 restores the association of PML with these promoters in PML-depleted cells. We identified a novel association between PML1 and WDR5, a key component of H3K4 methyltransferase (HMTs) complexes that catalyze H3K4me1 and H3K4me3. ChIP-seq analyses showed that the loss of PML1 reduces H3K4me3 in numerous loci, including BCSC-associated gene promoters. Additionally, PML1, not PML4, re-establishes the H3K4me3 mark on these promoters in PML-depleted cells. Significantly, PML1 is essential for recruiting WDR5, MLL1, and MLL2 to these gene promoters. Inactivating WDR5 by knockdown or inhibitors phenocopies the effects of PML1 loss, reducing BCSC-related gene expression and tumorsphere formation and enhancing fulvestrant’s anticancer activity. Our findings challenge the conventional understanding of PML as a tumor suppressor, redefine its role as a promoter of tumor growth in breast cancer and offer new insights into the unique roles of PML isoforms in breast cancer.
The effect of the geometric influence of trichiral structures on mechanical properties
Authors: İnan Cevher Yusuf , Evis Zafer 
Published: September 2023

Abstract
Auxetic structures are used in many fields such as aerospace, protective equipment, and biomedical due to their extraordinary mechanical behavior. These structures, which are very difficult to manufacture since their lattice structure, can be produced precisely thanks to additive manufacturing. In this article, tri-chiral auxetic structures were designed, fabricated by additive manufacturing, mechanically tested, and a finite element modelling (FEM) was performed. The material model used in FEM was verified. Stress-strain curves were obtained by compression and tensile tests. Experimental and computational results were compared. The main focus of this study was to examine the effect of geometric dimensions of the tri-chiral structure on strength. Multiple regression analysis was applied to the experimental results and parameters that made a significant difference were determined. It was seen that while there is an inverse linear relationship between ligament length and strength, there is a parabolic relationship between thickness and strength. It was found that the tri-chiral structure generally has better against compressive load. In addition, a 4.5 times increase in tensile strength was observed with only the change in geometric dimensions. Thus, it was concluded that the geometrical dimensions significantly affect the mechanical properties of the structure.
Monitoring of phenology and irrigation response of artificial forests based on vegetation remote sensing
Authors: guan peng , Zhu chen Li , Lei Guannan , Zheng Yili 
Published: September 2023

Abstract
Background Although the study of the environmental factors on forest phenology has attracted the attention, and it proposes the influences of moisture and precipitation in the rainy season on the growth change of Populus tomentosa. Methods Here, the near-earth remote sensing devices are applied to monitor the canopy phenology of the planted forest Populus tomentosa B301 cultivated under the full drip irrigation (DIFI), controlled drip irrigation (DICI) and non-irrigation group (CK), calculate the relative green vegetation index, adopt the TIMESAT3.3 procedure to fit the time series curve of phenological index of Populus tomentosa B301, as well as extract the key period of phenological growth. Results Our results showed that: 1) The data of the relative green vegetation index and the forest growth rate of change are different. The tree species under non-irrigation will reach the growth peak at the day 138, 2 days later than the full drip irrigation and controlled drip irrigation; 2) The tree species in the DICI area wither and fall on the day 269, while that in the CK and DIFI area withers and falls on the day 270. The growth season of CK, DIFI and DICI areas ends on the day 307, 315 and 295, respectively. 3) Different irrigation conditions have different responses to forests, and the use of irrigation conditions changes the growth and development process of forests, resulting in significant phenological effects. Conclusions These findings Irrigation has a significant effect on reducing greenhouse gas emissions in forests and can improve water resource utilization efficiency, the stable ecological environment could promote the forest growth.
Oxidative-stress-responsive kinase 1 is the master regulator of proximal tubular sodium transport
Authors: Nakamura Motonobu , Seki George , Satoh Nobuhiko , Takagi Mayuko , Mizuno Tomohito , Tsukada Hiroyuki , Horita Shoko , Sato Yusuke , Kume Haruki , Nangaku Masaomi 
Published: September 2023

Abstract
The with-no-lysine kinase (WNK)/SPS1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (Oxsr1) pathway plays a vital role in renal Na transport in distal nephrons as a master regulator of chloride co-transporters. We previously reported that PPARγ agonists, insulin, and angiotensinII stimulate Na transport in the proximal tubule (PT). Although we suggested the existence of a master regulator, its role remained unclear. Herein, we aimed to investigatewhether the WNK1/Oxsr1 pathway is the master regulator of PT Na transport using isolated human and rat PTs. WNK or SPAK/Oxsr1 inhibitors entirely suppressed the stimulatory effects of insulin or angiotensin II on PT Na reabsorption in freshly isolated human and rat PTs. Furthermore, the sodium-glucose cotransporter (SGLT)2 inhibitor canagliflozin inhibited Oxsr1 phosphorylation, indicating that the SGLT2-regulated WNK1/Oxsr1 pathway integrally regulates Na transport stimulation in the PT. This indicates that Oxsr1 is the master regulator of PT Na reabsorption, and that SGLT2 regulates Oxsr1.
Evaluation the experiences of Iranian women of care during labor and physiological childbirth: Mixed Method Study
Authors: Khodarahmi Shiva , Hajian Sepideh , Zare Elham , Nasiri Malihe 
Published: September 2023

Abstract

Background: Childbirth is considered as a natural and physiological process that has an important effect on the health of mother and newborn. The objective of this study was to investigate the experiences of Iranian women of care during labor and physiological childbirth.
Methods: The present study was conducted by sequential-explanatory mixed method in Hamadan. The first stage was a cross-sectional study on 135 female who were included by convenience sampling method. Data collection tools were Childbirth Experience Questionnaire and Checklist of Assessment of Care during Labor and Physiological Childbirth. The second stage of the study, with the participation of 30 women, was conducted qualitatively 6 months after childbirth using in-depth individual interviews. The results were analyzed by conventional content analysis approach. The quantitative and qualitative data were analyzed using software SPSS 24 and MAXQDA 10.
Results: The total mean score of childbirth experience was 71.98 ± 12.37 out of 100. For different dimensions of childbirth experience, support of care providers (3.47 ±0.54) and individual capacity (3.13 ±0.55) out of 4, had the highest and lowest mean scores of childbirth experience. The process of data analysis at the second stage of the study led to the emergence of 53 final codes, 21 sub-categories, 10 categories and 4 themes include: "different emotional emotions", "service satisfaction", "pleasant experience" and "pleasant experience inhibitors".
Conclusions: Care provided to women based on the principles of physiological childbirth by increasing the security and control, plays a key role in causing a pleasant experience of childbirth.
Incremental dose-response effect of age on mortality in non-seminoma testis cancer patients
Authors: Incesu Reha-Baris , Piccinelli Mattia Luca , Morra Simone , Scheipner Lukas , Tappero Stefano , Barletta Francesco , Garcia Cristina Cano , Tian Zhe , Saad Fred , Shariat Shahrokh F. , Chun Felix K. H. , Briganti Alberto , Terrone Carlo , Ahyai Sascha , Longo Nicola , de Cobelli Ottavio , Tilki Derya , Graefen Markus , Karakiewicz Pierre I. 
Published: September 2023

Abstract
Background
Age ≥ 40 predisposes to higher testis cancer-specific mortality (CSM) in non-seminoma. However, it is unknown, whether an incremental dose-response effect applies to subgroups of testis cancer patients (tertiles aged ≥ 40). We tested this hypothesis in contemporary non-seminoma patients.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database (2004 − 2018) was used. Kaplan-Meier plots and multivariable Cox regression models tested the effect of age on CSM after stratification for stage (I vs. II vs. III).
Results
Of 13,679 non-seminoma patients, 11,034 (81%) were aged < 40 vs. 2,645 (19%) were aged ≥ 40. Of patients aged ≥ 40, 943 were aged 40–44 (young age tertile) vs. 855 were aged 45–52 (intermediate age tertile) vs. 847 were aged ≥ 53 (old age tertile). In overall multivariable analyses relative to patients aged < 40, young age tertile (HR 1.4, p < 0.01), intermediate age tertile (HR 1.9, p < 0.001) and old age tertile (HR 3.6, p < 0.001) were associated with higher CSM. In stage-specific multivariable analyses relative to patients aged < 40, old age tertile predicted higher CSM in stage I (HR 4.7, p < 0.001), stage II (HR 9.9, p < 0.001) and stage III (HR 3.0, p < 0.001). In stage III, intermediate age tertile (HR 1.9, p < 0.001) and young age tertile (HR 1.5, p = 0.007) also predicted higher CSM.
Conclusions
We identified a dose-response effect of increasing age in non-seminoma patients aged ≥ 40, in the overall analysis as well as in stage-specific analyses.
Plant variety selection using interaction classes derived from Factor Analytic Linear Mixed Models: models with information on genetic relatedness
Authors: Smith Alison Barbara , Hobson Kristy , Butler David , Cullis Brian Richard 
Published: September 2023

Abstract
Smith et al. (2021) introduced the interaction class (iClass) approach for multi-environment trials (METs) to address the problem of summarising variety performance across environments in the presence of variety by environment interaction. They developed the approach with respect to a factor analytic linear mixed model (FALMM) in which the genetic effects for different varieties were assumed independent. It is well known that the accuracy of variety selection is greatly enhanced by considering the genetic relatedness of varieties, either via ancestral or genomic information. In the current paper we therefore extend the iClass approach for FALMMs which incorporate such information. We illustrate the utility of the approach for selection of both parental and potential commercial varieties using an early stage breeding MET data-set from Chickpea Breeding Australia.
El Niño signals revealed by AMSU-A brightness temperature observations
Authors: Xia Xinlu , Zou Xiaolei , Zhang Wenjun 
Published: September 2023

Abstract
Reanalysis data are extensively employed in investigation of the tropical large-scale climate variability. In this study, we attempt to use the Advanced Microwave Sounding unit-A (AMSU-A) window channel brightness temperature (TB) observations to examine their relationship with the sea surface temperature (SST). A close relationship is found between the AMSU-A window channel TB and SST in the tropical oceans. A TB Niño Index (TNI) of AMSU-A window (sounding) channels is found to reach its maximum about 2 months ahead of Oceanic Niño Index (ONI) for half of El Niño cases from 1998 to 2020. The AMSU-A sounding channels TNI had minimum values about 1–3 months behind ONI peak month. Spatial correlation maps of AMSU-A window channel TB anomalies with TNI are similar to those of SST anomalies with ONI, featuring a horseshoe-shaped pattern in the tropical Pacific and a dipole-shaped pattern in the tropical Indian Ocean. The AMSU-A retrieved liquid water path (LWP) is also highly correlated with the ONI, with larger values in El Niño years. An active development of tropical convective disturbances and their movement associated with westerly wind bursts may be the reason for the peak TNI to occur 1–3 months earlier than the peak ONI. The potential for AMSU-A TB observations to reveal El Niño signals adds additional satellite data source for El Niño research.
Study on the Impact of Smart City Development on Carbon Emission Efficiency Enhancement in Resource-Based Cities Pursuing Carbon Neutrality Goal
Authors: Wang Chensheng , Han Yukai , Liu Jing 
Published: September 2023

Abstract
This study uses panel data from 114 resource-based cities (RBCs) in China spanning from 2004 to 2018. Employing the super-efficient slack based measure (SBM) model with unexpected outputs, we measure the carbon emission efficiency (CEE) of these cities. Further, the difference-in-differences (DID) model is employed to systematically analyze the effects and underlying mechanisms of smart city pilot policy (SCPP) on CEE in the context of carbon neutrality goals. The findings indicate: (1) There are notable regional disparities in CEE among China’s RBCs. Cities in the eastern region outperform those in the central and western regions. However, the CEE in the central and western cities has improved over time. (2) SCPP have significantly enhanced CEE in RBCs. (3) The efficacy of the SCPP on CEE in RBCs is moderated by advanced human capitalization, green innovation capacity, and the industrial structure advanced Level. (4) The impact of SCPP on the CEE of RBCs varies based on city location and city type.
Effects of the Geometric Characteristics of Graphene Nanoplatelets on the Physico-Rheological Properties of Asphalt Binder
Authors: Almashaqbeh Hashem Khaled , Rushing Grace , Doyle Jesse , Sengottuvelu Dineshkumar , Majdoub Mohammed , Al-Ostaz Ahmed H , Alkhateb Hunain , Nouranian Sasan , Ucak-Astarlioglu Mine 
Published: September 2023

Abstract
While graphene nanoplatelets (GnPs) have emerged as promising nano-modifiers of asphalt binder in recent years, much is still unknown in terms of the existing correlations between the physical, chemical, and geometric characteristics of this nanofiller and observed asphalt binder properties. In this work, we investigate the important correlation between the geometric characteristics of GnPs and the rheological properties of the GnP-modified asphalt binder at high temperatures. Our results indicate that, in general, incorporating GnPs with large mean particle diameters (> 14 µm) and thicknesses (> 8 nm) enhances the high-temperature performance of the asphalt binder. The results of the multiple stress creep and recovery tests confirm that including GnPs in asphalt binder can decrease its permanent deformation by 33.2% and enhance its elastic recovery by 53.9%. Phase images obtained by atomic force microscopy further indicate that the presence of GnPs with large mean particle diameters alters the morphology of the asphalt binder, leading to improved temperature stability and less susceptibility to permanent deformation.
Dynamic output feedback stabilization for a class of nonsmooth stochastic nonlinear systems perturbed by multiple time-varying delays
Authors: Jia Jinping , Dai Hao , Zhang Fandi , Huang Jianwen 
Published: September 2023

Abstract
In this paper, the output feedback stabilization problem is investigated for a class of low-order stochastic nonlinear time-delay systems with the lower-triangular form, where the powers of chained integrators are arbitrary real numbers between 0 and 1, and the multiple time-vary delays act on each system state. Because of the existence of low-order nonlinear terms, the system is not feedback linearizable and differentiable. Nevertheless, we show that an output feedback controller can be systematically designed to ensure the global strong asymptotic stability of the closed-loop system based on an extended stochastic stability theory. In the controller design, the negative effect of the multiple time-varying delays is counteracted by skillfully constructing a novel Lyapunov-Krasovskii functional, and the observer gains are determined by developing a recursive selection procedure. Finally, a numerical example is provided to verified the effectiveness of the proposed method.
Fiber-Type Electrodes for Improved Actuation of Dielectric Elastomer Actuators
Authors: Chortos Alex , Firoozan Mohammadreza , Baghani Mostafa 
Published: September 2023

Abstract
Dielectric elastomer actuators (DEAs) exhibit fast actuation and high efficiencies, enabling applications in optics, wearable haptics, and insect-scale robotics. However, the non-uniformity and high sheet resistance of traditional soft electrodes based on nanomaterials limit the performance and operating frequency of the devices. In this work, we computationally investigate electrodes composed of arrays of stiff fiber electrodes. Aligning the fibers along one direction creates an electrode layer that exhibits zero stiffness in one direction and is predicted to possess high and uniform sheet resistance. A comprehensive parameter study of the fiber density and dielectric thickness reveals that the fiber density primary determines the electric field localization while the dielectric thickness primarily determines the unit cell stiffness. These trends identify an optimal condition for the actuation performance of the aligned electrode DEAs. This work demonstrates that deterministically designed electrodes composed of stiff materials could provide a new paradigm with the potential to surpass the performance of traditional soft planar electrodes.
Family and Job Microsystems as Mediators between Social Integration and Depression among Rural-to-urban Migrant Workers in China: Does Having Sons Make a Difference?
Authors: Shen Guanghui , Tang Jiayi , Fang Juan , Huang Jiahui , Zheng Yawen , Wu Liujun , Yang Xudong , Chen Yu-Hsin , Chen Li 
Published: September 2023

Abstract

Background
Rural-to-urban migrant workers are a vulnerable group at risk of developing depression. Based on the social-ecological systems theory, this study investigates the impact of the lack of social integration on depression, considering the mediating roles of migrant workers' microsystems (family happiness and job burnout). Additionally, the study explores whether having sons influences these associations.
Methods
The sample of 4618 rural-to-urban migrant workers was obtained from the 2018 wave of the China Labor Force Dynamics Survey (CLDS). All the measures in the survey exhibited good reliability, including the Center for Epidemiological Research Depression Scale (CES-D), family happiness, job burnout, and social integration. The data were primarily analyzed using a structural equation model.
Results
Social integration had a direct impact on depression among migrant workers. Additionally, it indirectly affected depression through the mediating roles of family happiness not job burnout. The moderating effect of having sons mainly occurred on the path from social integration to family happiness.
Limitations:
The cross-sectional design impeded the ability to draw causal inferences.
Conclusions
This finding highlights the potential benefits of social integration and family happiness in promoting early prevention of depression among migrant workers. It indicates that the inclination towards having sons among migrant workers continues to impact their mental health.