bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmaceutico Analytical Study of Roudra Rasa and Evaluation of Its Anti-Carcinogenic Effect in Selected Cell Lines and Acute Toxicity Studies in Albino Wistar Rats: A Study Protocol
Authors: Khabade Swapnali , Rathi Bharat , Rathi Renu , Chaudhary Piyush 
Published: January 2023

Introduction: There are expected to have become 1.9 million new cancer diagnoses and 609,360 cancer - related deaths in 2022, or about 1,670 mortality each day. Regardless of human development level, throughout the world, the disease is a leading source of morbidity and mortality. Cancer like disorders have been documented also in Indian subcontinent since antiquity. In the 19th century, the very first cancer cases were diagnosed, and the burden of cancer began to climb in the 20th century, when current treatment facilities were severely inadequate. Roudra Rasa is a special Ayurvedic preparation for Arbuda (Cancer) mentioned in Bhaishajya Ratnavali. It has already been tested clinically in Oropharengeal cancer, with Ayurvedic treatment incorporating Roudra Rasa showing a greater benefit. Cancer cell lines of human are useful models for exploring cancer biology and testing the treatment effectiveness of anti - cancer drugs in the lab. That’s why Michigan Cancer Foundation-7 (MCF-7 - Breast), Human Colorectal Adenocarcinoma Cell Line (HT-29 - Colon), Human Lung Adenocarcinoma (HOP-62), Lung cancer epthelial cell (A549 - Lung), and cell line from prostate carcinoma (DU145), prostate cancer cell line (PC-3 - Prostate), these cancer cell lines have chosen to examine Roudra Rasa's anti cancer activity.
Aim and Objectives: Pharmaceutico analytical study of Roudra Rasa and evaluation of its Anti-carcinogenic And acute toxicity studies in selective cell lines and albino Wistar rats respectively.
Materials and Methods: Roudra Rasa will be prepared by traditional method and quality control parameters will be assessed. Anti-carcinogenic activity will be carried out in selected cancer cell lines. and acute toxicity testing will be done in accordance with OECD guidelines 423.
Observations and Results: Observations of pharmaceutical, analytical and experimental studies will be noted and presented in the forms of table, charts, photographs etc.
Conclusion: If Roudra Rasa shows any significant Anti-Carcenogenic activity then it would be safe and efficient medicine for Cancer.
Comparison of antipsychotic prescribing practices following failure of antipsychotic monotherapy in the acute care setting
Authors: Morgan Kaitlyn , Rickert Leah 
Published: January 2023

Abstract

Introduction
Numerous strategies exist following antipsychotic monotherapy failure including transition to another antipsychotic, dosing above FDA recommendations, or dual antipsychotic therapy. This study described antipsychotic prescribing practices on an acute psychiatry unit following antipsychotic monotherapy failure and compared outcomes to determine if any strategy resulted in superior short-term outcomes.

Methods
This retrospective chart review assessed postintervention time to discharge for patients with schizophrenia or schizoaffective disorder requiring therapy change following treatment failure. Secondary outcomes included 30-day readmission rate, length of stay, and discharge chlorpromazine equivalents.

Results
There were no differences in number of past antipsychotic trials between groups (4.8 vs 4.5; P = .73). Of all the patients, 73% (n = 30) discharged on alternative antipsychotic monotherapy while 27% (n = 11) discharged on dual antipsychotic therapy. No patients had doses increased above FDA recommendations. The alternative antipsychotic group had shorter mean postintervention time to discharge (8.8 vs 20.6 days; P = .003) and shorter mean length of stay (16.7 vs 32.1 days; P = .03). Median time to discharge was not statistically significant (6.4 vs 14.0 days; P = .17). The dual antipsychotic group had higher mean chlorpromazine equivalents (723 mg vs 356 mg; P = .002). There was no difference in 30-day readmission rates (16.7% vs 27.3%; χ2 = 0.5765; P = .45).

Discussion
This study found that following failure of antipsychotic monotherapy, transition to an alternative antipsychotic was associated with decreased mean time to discharge as compared to dual antipsychotic therapy. Further studies are needed to assess long-term clinical implications of these findings.
A sobrevida da agenda pós-moderna e seus malabarismos teórico-políticos
Authors: Della Fonte Sandra Soares 
Published: January 2023

Pontuam-se aspectos da construção e das repercussões do discurso pós-moderno no campo educacional brasileiro para evidenciar, à semelhança do que Moraes fez no início dos anos 2000, o seu renovado conservadorismo. Para tanto, ressaltam-se a estruturação desse discurso como uma agenda e alguns de seus rearranjos, em especial os que derivam de seus intelectuais de esquerda. Discutem-se ainda as reações do campo educacional brasileiro diante desses rearranjos. A relação orgânica entre neoliberalismo e neoconservadorismo, assim como pandemia mundial de Covid-19 têm tornado mais evidentes e profundas as aporias e (des)caminhos dessa agenda. A crítica a qualquer relativismo da verdade e depreciação da ciência tem sido assumida por vários segmentos sociais progressistas, fato que, por um lado, favorece a luta contra argumentações da agenda pós, por outro, pode se reverter em força para a renovação de seu conservadorismo.
Characteristics and Outcomes for Hospitalized Patients With Cutaneous T-Cell Lymphoma
Authors: Glinos George , Wei Grace , Nosewicz Jacob , Abdulla Farah , Chen Pei-Ling , Chung Catherine , Kaffenberger Benjamin H. , Querfeld Christiane , Shinohara Michi M. , Sokol Lubomir , Zain Jasmine , Kumar Ambuj , Seminario-Vidal Lucia 
Published: January 2023

ImportanceCutaneous T-cell lymphoma (CTCL) is a group of rare, complex cutaneous malignant neoplasms associated with significant disease burden on patients and the health care system. Currently, the population of patients with CTCL admitted to the hospital remains largely uncharacterized and poorly understood.ObjectiveTo characterize the clinical characteristics, course of hospitalization, and mortality outcomes of an inpatient CTCL cohort.Design, Setting, and ParticipantsThis multicenter retrospective cohort study reviewed medical records for adult patients (age ≥18 years) with a CTCL diagnosis per National Comprehensive Cancer Network guidelines admitted for inpatient hospitalization at 5 US academic medical centers with inpatient dermatology consult services and CTCL clinics between August 2016 and August 2020.Main Outcomes and MeasuresPatient demographics, clinical history and findings, hospitalization courses, and mortality outcomes.ResultsA total of 79 hospitalized patients with CTCL were identified, including 52 (70.3%) men and 22 (29.7%) women, with a median (IQR) age at hospitalization of 62.9 (27-92) years. The majority of admitted patients with CTCL were White (65 patients [82.3%]), had disease classified as mycosis fungoides (48 patients [61.5%]), and had advanced-stage disease (≥IIB, 70 patients [89.7%]). Most hospitalizations were complicated by infection (45 patients [57.0%]) and required intravenous antibiotic therapy (45 patients [57.0%]). In-hospital mortality occurred in 6 patients (7.6%) and was associated with higher body mass index (36.5 vs 25.3), history of thromboembolic disease (50.0% vs 12.3%), and diagnosis of sepsis on admission (66.7% vs 20.5%). At 1-year postdischarge, 36 patients (49.3%) patients had died, and mortality was associated with history of solid organ cancers (27.8% vs 10.8%), wound care as the reason for dermatology consultation (58.3% vs 24.3%), and presence of large cell transformation (58.3% vs 22.9%).Conclusions and RelevanceThe findings of this cohort study improve the understanding of hospitalized patients with CTCL and lend valuable insight into identifying factors associated with both in-hospital and long-term mortality outcomes. This refined understanding of the inpatient CTCL population provides a foundation for larger, more robust studies to identify causal risk factors associated with mortality, development of prognostic scoring systems to estimate the probability of hospital mortality. Overall, the findings may prompt physicians caring for patients with CTCL to implement preventive strategies to diminish hospitalization and improve clinical management across this unique disease spectrum.
Comparison of Opioids Prescribed by Advanced Practice Clinicians vs Surgeons After Surgical Procedures in the US
Authors: Priest Caitlin R. , Waljee Jennifer F. , Bicket Mark C. , Hu Hsou-Mei , Chua Kao-Ping 
Published: January 2023

ImportanceAdvanced practice clinicians (APCs), defined as nurse practitioners and physician assistants, are increasingly being incorporated into surgical teams. Despite this inclusion, there are no recent national data on the role of these clinicians in surgical opioid prescribing or the dosing of such prescriptions.ObjectiveTo calculate the proportion of surgical opioid prescriptions written by APCs and to compare the total and daily dosages of these prescriptions with those written by surgeons.Design, Setting, and ParticipantsThis cross-sectional study used the Optum’s De-Identified Clinformatics Data Mart, which contains deidentified claims from patients with private insurance and Medicare Advantage plans across the US. Adults and children who underwent 1 of 31 inpatient and outpatient surgical procedures from January 1, 2017, through November 30, 2019, were identified. The analysis was limited to procedures with 1 or more perioperative opioid prescriptions, defined as an opioid prescription dispensed within 3 days of the index date of surgery. Data were analyzed from April 1, 2021, to July 31, 2022.ExposuresPrescriber specialty.Main Outcomes and MeasuresThe outcome was the proportion of perioperative opioid prescriptions and refill prescriptions written by APCs. Linear regression was used to compare the total dosage of perioperative opioid prescriptions written by APCs vs surgeons measured in morphine milligram equivalents (MMEs). Models were adjusted for demographic characteristics, comorbidities, opioid-naive status, year of index date, hospitalization or observation status, surgical complications, and surgeon specialty. Analyses were conducted at the procedure level, and patients with multiple procedures were included.ResultsAnalyses included 628 197 procedures for 581 387 patients (358 541 females [57.1%]; mean [SD] age, 56 [18] years). Overall, APCs wrote 119 266 (19.0%) of the 628 197 perioperative opioid prescriptions and 59 679 (25.1%) of the 237 740 refill prescriptions. Perioperative opioid prescriptions written by APCs had higher total dosages compared with those written by surgeons (adjusted difference, 40.0 MMEs; 95% CI, 31.3-48.7 MMEs). This difference persisted in a subgroup analysis limited to opioid-naïve patients (adjusted difference, 15.7 MMEs; 95% CI, 13.9-17.5 MMEs).Conclusions and RelevanceIn this cross-sectional analysis, one-fifth of perioperative opioid prescriptions and one-quarter of refill prescriptions were written by APCs. While surgeons wrote most perioperative opioid prescriptions that were intended for perioperative analgesia, higher total dosages from APCs suggest that opioid stewardship initiatives that support the role of APCs may be warranted.
2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases
Authors: Bass Anne R. , Chakravarty Eliza , Akl Elie A. , Bingham Clifton O. , Calabrese Leonard , Cappelli Laura C. , Johnson Sindhu R. , Imundo Lisa F. , Winthrop Kevin L. , Arasaratnam Reuben J. , Baden Lindsey R. , Berard Roberta , Bridges S. Louis , Cheah Jonathan T. L. , Curtis Jeffrey R. , Ferguson Polly J. , Hakkarinen Ida , Onel Karen B. , Schultz Grayson , Sivaraman Vidya , Smith Benjamin J. , Sparks Jeffrey A. , Vogel Tiphanie P. , Williams Eleanor Anderson , Calabrese Cassandra , Cunha Joanne S. , Fontanarosa Joann , Gillispie‐Taylor Miriah C. , Gkrouzman Elena , Iyer Priyanka , Lakin Kimberly S. , Legge Alexandra , Lo Mindy S. , Lockwood Megan M. , Sadun Rebecca E. , Singh Namrata , Sullivan Nancy , Tam Herman , Turgunbaev Marat , Turner Amy S. , Reston James 
Published: January 2023

ObjectiveTo provide evidence‐based recommendations on the use of vaccinations in children and adults with rheumatic and musculoskeletal diseases (RMDs).MethodsThis guideline follows American College of Rheumatology (ACR) policy guiding management of conflicts of interest and disclosures and the ACR guideline development process, which includes the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. It also adheres to the Appraisal of Guidelines for Research and Evaluation (AGREE) criteria. A core leadership team consisting of adult and pediatric rheumatologists and a guideline methodologist drafted clinical population, intervention, comparator, outcomes (PICO) questions. A review team performed a systematic literature review for the PICO questions, graded the quality of evidence, and produced an evidence report. An expert Voting Panel reviewed the evidence and formulated recommendations. The panel included adult and pediatric rheumatology providers, infectious diseases specialists, and patient representatives. Consensus required ≥70% agreement on both the direction and strength of each recommendation.ResultsThis guideline includes expanded indications for some vaccines in patients with RMDs, as well as guidance on whether to hold immunosuppressive medications or delay vaccination to maximize vaccine immunogenicity and efficacy. Safe approaches to the use of live attenuated vaccines in patients taking immunosuppressive medications are also addressed. Most recommendations are conditional and had low quality of supporting evidence.ConclusionApplication of these recommendations should consider patients’ individual risk for vaccine‐preventable illness and for disease flares, particularly if immunosuppressive medications are held for vaccination. Shared decision‐making with patients is encouraged in clinical settings.
High‐Efficiency Solid‐State Luminescence from Hydrophilic Carbon Dots with Aggregation‐Induced Emission Characteristics
Authors: Wan Zhijun , Li Yuemiao , Zhou Yizi , Peng Dongping , Zhang Xuejie , Zhuang Jianle , Lei Bingfu , Liu Yingliang , Hu Chaofan 
Published: January 2023

AbstractCarbon dots (CDs) have excellent properties and have made great progress in synthesis and applications. However, it is still a challenge to realize convenient preparation and highly emissive solid‐state luminescence without the assistance of matrix. In this study, high‐efficiency hydrophilic yellow emissive CDs (Y‐CDs) with aggregation‐induced emission (AIE) characteristics are synthesized by a one‐pot microwave method. Y‐CDs show weak yellow emission with a photoluminescence quantum yield (PLQY) of 6.14% in aqueous solutions, but exhibit a significantly enhanced PLQY of 58.35% in the solid state. The AIE characteristic is confirmed by the phenomenon that the fluorescence emission intensity of Y‐CDs continues to increase with the gradual increase of the poor solvent fraction. The AIE phenomenon of Y‐CDs is derived from the suppression of surface piperazine groups motions and decrease of the non‐radiative rate, as is verified by a series of experiments. Finally, based on the high PLQY and AIE property, Y‐CDs are applied as a color‐converting layer on blue‐light‐emitting chips to fabricate white‐light‐emitting diodes with color coordinates of (0.31, 0.35), while Y‐CDs are also explored for their potential applications in anti‐counterfeiting, encryption and bioimaging.
Pre‐Protonated Vanadium Hexacyanoferrate for High Energy‐Power and Anti‐Freezing Proton Batteries
Authors: Dong Xiaoyu , Li Zhiwei , Luo Derong , Huang Kangsheng , Dou Hui , Zhang Xiaogang 
Published: January 2023

AbstractProton batteries have been considered as an innovative energy storage technology owing to their high safety and cost‐effectiveness. However, the development of fast‐charging proton batteries with high energy/power density is greatly limited by feasible material selection. Here, the pre‐protonated vanadium hexacyanoferrate (H‐VHCF) is developed as a proton cathode material to alleviate the capacity loss of proton‐free electrode materials during electrochemical tests. The pre‐protonation process realizes fast and long‐distance transport of protons by shortening diffusion path and reducing migration barriers. Benefitting from the enhanced hydrogen bonding network combined with dual redox reactions of V and Fe in protonated H‐VHCF cathode, a high energy density of 74 Wh kg−1 at 1.1 kW kg−1, and a maximum power density of 54 kW kg−1 at 65 Wh kg−1 is achieved for the asymmetric proton batteries coupling with MoO3/MXene anode. Proton transport and double oxidation‐reduction center are verified by theoretical calculations and ex situ experimental measurements. Considering the anti‐freezing availability of proton batteries, 82.5% of its initial capacity is maintained after 10000 cycles under −40 °C at 0.5 A g−1. As a proof‐of‐concept, flexible device fabricated by optimized electrodes and hydrogel electrolytes can power up a light‐emitting diode even under a bent state.
Intrinsically Low Lattice Thermal Conductivity and Anisotropic Thermoelectric Performance in In‐doped GeSb2Te4 Single Crystals
Authors: Chen Peng , Wu Hong , Zhang Bin , Zhou Zizhen , Zheng Sikang , Dai Lu , Huo Yufeng , Zhang De , Yan Yanci , Peng Kunling , Han Guang , Lu Xu , Zhou Xiaoyuan , Wang Guoyu 
Published: January 2023

AbstractLayer‐structured GeSb2Te4 is a promising thermoelectric candidate, while its anisotropy of thermal and electrical transport properties is still not clear. In this study, Ge1–xInxSb2Te4 single crystals are grown by Bridgman method, and their anisotropic thermoelectric properties are systematically investigated. Lower electrical conductivity and higher Seebeck coefficient are observed in the c‐axis due to the higher effective mass in this direction. Intrinsically low lattice thermal conductivity is also observed in the c‐axis due to the weak chemical bonding and the strong lattice anharmonicity proved by density functional theory calculation. Indium doping introduces an impurity band in the bandgap of GeSb2Te4 and leads to the locally distorted density of states near the Fermi level, which contributes to enhanced Seebeck coefficient and improved power factor. Ultimately, a peak zT value of 1 at 673 K and an average zT value of 0.68 within 323–773 K are obtained in Ge0.93In0.07Sb2Te4 along the c‐axis direction, which are 54% and 79% higher than that of the pristine GeSb2Te4 single crystal, respectively. This study clarified the origin of intrinsic low lattice thermal conductivity and anisotropy transport properties in GeSb2Te4, and shed light on the performance optimization of other layered thermoelectric materials.
A Thermodynamic Cycle‐Based Electrochemical Windows Database of 308 Electrolyte Solvents for Rechargeable Batteries
Authors: Wang Da , He Tingting , Wang Aiping , Guo Kai , Avdeev Maxim , Ouyang Chuying , Chen Liquan , Shi Siqi 
Published: January 2023

AbstractRational design of wide electrochemical window (ECW) electrolytes to pair with high‐voltage cathodes is an emerging trend to push the energy density limits of current rechargeable batteries. Traditional single‐electronic/gas‐phase approximation‐based methods (e.g., highest occupied molecular orbital/lowest unoccupied molecular orbital) are increasingly recognized to have large deviations from experiments when predicting ECWs of electrolytes involving complex solvent interactions. Specifically, by examining available experimental ECWs of 68 electrolyte solvents extracted from ≈140 000 literature sources, which are conventionally divided into five functional‐group categories (covering commonly used carbonate‐based ethylene carbonate (EC)/propylene carbonate (PC) and ether‐based tetrahydrofuran), it is found that mean‐absolute‐errors (MAE) of traditional methods reach up to 3.25 V. Herein, a thermodynamic cycle‐based ECW prediction approach is proposed including two long‐term overlooked reorganization‐energy and solvation‐energy corrections, each of which can be quantified by two geometric descriptors (λ and ΔGsol), reducing MAE below 0.68 V. Following this, a database containing ECWs for 308 electrolyte solvents, obtained by traversing single functional‐group substitutions, is established. Furthermore, two omitted solvents with ECWs over 6.00 V and excellent structural stabilities (bond‐length change < 0.10 Å during redox process) are retrieved by stepwise screening of structural/electronic parallel properties. This study demonstrates the benefits of improving ECW prediction accuracy and accumulating descriptors to accelerate rapid screening of superior battery electrolytes.
Transparent High‐Performance Supramolecular Plastics Operating in All‐Weather Environments
Authors: Chen Jiaoyang , Ma Yuhong , Chen Tao , Du Yingjie , Xu Jianhua , Wang Dong , Yang Jing , Hu Po , Jing Jiajie , Yao Bowen , Fu Jiajun 
Published: January 2023

AbstractSupramolecular plastics (SMPs) can be made mechanically robust, repairable, and recyclable, rendering themselves promising alternatives to their conventional predecessors to address environmental concerns. However, dense accumulations of noncovalent bonds generally lead to mechanical brittleness as well as intolerance toward heat and moisture. To resolve this issue, a simple strategy of preparing high‐performance SMP by constructing highly dense, but irregular hydrogen‐bond networks with hierarchical structures is proposed. The resultant SMP exhibits an outstanding combination of good comprehensive mechanical properties (high stiffness, strength, and toughness with ductile failure when fracturing), excellent dynamic behaviors (repairability and recyclability), and high tolerances toward moisture and high temperatures (as high as 90 °C). Additionally, the SMP also shows a high dielectric constant, exhibiting great potential for applications such as healable flexible touch screens and energy storage. Last, through structure characterizations and molecular dynamic simulation, this study provides a fundamental insight into the mechanism behind such high‐performances from nano‐ to micro‐scales, which is expected to inspire the design of a wide range of other SMPs that use different chemistries.
Efficient, Color‐Stable, and Long‐Lived White Organic Light‐Emitting Diodes Utilizing Phosphorescent Molecular Aggregates
Authors: Ameri Lydia , Cao Linyu , Tan Xinqiang , Li Jian 
Published: January 2023

AbstractHighly efficient and stable single‐stack hybrid white organic light‐emitting diode (WOLED) devices are developed using two emissive layers: one with amber‐colored phosphorescent molecular‐aggregate emission from the Pd(II) complex, Pd(II) 7‐(3‐(pyridine‐2‐yl‐κN)phenoxy‐κC)(benzo‐κC)([c]benzo[4,5]imidazo‐κN)[1,2‐a][1,5]naphthyridine, Pd3O8‐Py5, and the other with blue fluorescence emission. An optimized device structure achieves high color stability under various current densities, an external quantum efficiency (EQE) of 45.5%, a power efficiency of 97.4 Lm W−1, and an estimated LT95 (operational time to 95% of the initial luminance) of 50 744 h at an initial luminance of 1000 cd m−2.