bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Ethics Training on the Employees’ Information Security Compliance Intentions
Authors: Lee Yongbin , Oh Seungmin 
Published: May 2023

Abstract
Organizations must ensure that employees maintain information security policy (ISP) compliance intentions with respect to published policies to improve their information security (IS) posture. Employees’ noncompliance behaviors make them the weakest link in organizations’ IS. Researchers in different fields of studies utilized ethics training and provided evidence that it has positive effects on employees’ compliance intentions. However, despite the capabilities of ethics training in compliance intention improvement, IS research on the influence of ethics training on employees’ ISP compliance intentions is limited. This nonexperimental quantitative explanatory study addressed the gap in empirical support for investigating whether ethics training influences employees’ ISP compliance intentions.
Diastolic Dysfunction in Cirrhotic Cardiomyopathy: A Prospective Observational Cohort Study on Short-Term Outcomes in Cirrhotic Patients Undergoing TIPS
Authors: Liu Yaozu , Meng Fangmin , Ma Jingqin , Zhang Wen , yu Jiaze , Zhou Yongjie , Zuo Wuxu , Yan Zhiping , Pan Cuizhen , Luo Jianjun 
Published: May 2023

Abstract
Background: The placement of Transjugular intrahepatic portosystemic shunt (TIPS) results in a sudden increase in central circulating blood volume, which requires proper regulation of the cardiovascular system. The presence of diastolic dysfunctional cirrhotic cardiomyopathy (CCM) indicates myocardial dysfunction which may lead to adverse outcomes in patients treated TIPS. The aim of our study was to investigate the impact of diastolic dysfunction on TIPS.
Method: A consecutive case series of patients with cirrhosis aged 18-65 years who underwent TIPS were prospectively studied.
Results: From June 2020 to January 2022, 82 patients were included. According to the Cirrhotic Cardiomyopathy Consortium (CCC), 48.8% had no LVDD, 20.7% had grade 1, 14.6% had grade 2, and 15.9% were indeterminate. The incidence of diastolic dysfunctional CCM is 14.6% in our study. The results indicate that RAP increased after TIPS and returned to baseline after 48 hours in patients with CCM (4.63±2.46 VS 6.42±2.75 p=0.076). In contrast, patients without CCM had lower RAP than baseline after 48 hours (4.63±3.05 VS 5.64±3.19, p=0.001).And no statistical significance was observed in the comparison of various pressures at different times between CCM and non-CCM patients (p>0.05). At the end of follow-up, 5(6.1%) patients died. LAVi(P=0.049, HR 1.169, 95%CI [1.001-1.365]), MELD score(P=0.026, HR=3.082, 95%CI [1.142-8.319]) and preoperative RAP (p =0.044, HR=2.015, 95%CI [1.018-3.987])were significantly associated with the mortality.
Conclusion: In conclusion, cirrhotic patients exhibit an effective regulatory capacity in response to hemodynamic alterations elicited by TIPS within short-term, irrespective of CCM presence.
Electrochemical immunosensor based on Al-TCPP nanomaterial adsorption aggregation signal amplification for the detection of dengue virus NS1 protein
Authors: zhang zixuan , li wei , liu jie , li ying , li chaorui 
Published: May 2023

Abstract
To detect the dengue virus NS1 protein with high sensitivity, this research suggests an electrochemical immunosensor based on the Al-TCPP adsorption aggregation signal amplification approach. We created a type of metal-organic framework (MOF) material called astrophytum myriostigma, which resembles a cactus plant and has a large specific surface area. Additionally, it can produce electrostatic attraction with the amino groups on methylene blue (MB), firmly fix MB on the MOF material, and manage MB reunion after adsorption, which is helpful for electron transmission and amplifies the electrical signal. The cationic dye methylene blue has redox characteristics. It possesses a high electron transfer rate, electrochemical reversibility, and strong biocompatibility. The generated electrochemical immunosensor has good reproducibility and stability, and the relationship between the analyte concentration and electrical signal strength is linear. The suggested immunosensor has a broad detection range from 10 fg/mL to 100 ng/mL with a low detection limit of 9.12 fg/ml under ideal conditions.
Suicide rates before and during the COVID-19 pandemic: a systematic review and meta- analysis
Authors: Varella Ana Paula da Cunha , Griffin Eve , Kabir Zubair 
Published: May 2023

Abstract
Purpose
The effects of the Covid-19 pandemic on mental health issues such as depression and anxiety are well-documented in the literature, but its influence on suicidal patterns shows divergent results. We aim to comprehensively synthesize evidence on potential changes or stability of suicide rates during the Covid-19 pandemic worldwide.
Methods
A comprehensive search of studies reporting suicide rates before and during the COVID-19 pandemic was conducted. Eligible studies reported incidences of confirmed suicides (suspected in special cases) for two time periods, before and during the COVID-19 pandemic. A meta-analysis of proportions using a random-effect model was performed to estimate the pre and during pandemic incidence rates of suicide with 95% confidence intervals. Differences in pre and during pandemic rates were formally tested using a heterogeneity test.
Results
A total of 34 studies were included in the review capturing suicide data from over 40 countries and regions. The meta-analysis outputs did not indicate a significant change in suicide rates during the COVID-19 pandemic. The pooled suicide rate in the studied period before the pandemic was 11.38 (95% CI 9.35–13.42) and in the period during the pandemic was 10.65 (95% CI 8.61–12.68).
Conclusion
No significant change in suicide rates was observed during the COVID pandemic from a global perspective for the periods examined. A longer follow-up can provide additional insights into such suicide trends globally. Improvements in data reporting, specifically with implementation of real-time surveillance, is imperative to provide adequate suicide prevention and support.
Long-term environmental enrichment prevents schizophrenia-like abnormalities and promotes hippocampal Slc6a4 gene demethylation in mice submitted to a two-hit model
Authors: Arraes Greicy Coelho , Barreto Francisco Stefânio , Vasconcelos Germana Silva , Lima Camila Nayane C. , Silva Francisco Eliclécio Rodrigues , Sousa Francisca Cléa Florenço , Libardi Cristiana , Macêdo Danielle S. 
Published: May 2023

Abstract
In the last decades, attention has been called to the need for preventive strategies against neurodevelopmental disorders. In the present study, we aimed to investigate the impacts of long-term environmental enrichment (EE) in preventing behavioral, neurochemical, and epigenetic changes in mice exposed to the two-hit model of schizophrenia. To this end, we used neonatal Swiss mice exposed to the viral mimetic polyinosinic:polycytidylic acid (PolyI:C) as first-hit on postnatal days (PND) 5–7 or sterile saline (zero-hit). On PND21, mice were randomly allocated to cages with standard (SE) or enriched environment (EE). From PND35-44, PolyI:C group was exposed to unpredictable stressors as second-hit. On PND70, after EE's last exposure, the animals underwent behavioral testing, and the hippocampus was collected for biochemical (Iba-1 and DCX) and epigenetic (SLC6A4 gene) analysis. The results showed that fifty days of EE exposure to two-hit mice, i.e., from infancy to adulthood, prevented sensorimotor gating deficits and working memory impairment while improving locomotor and exploratory activity. Furthermore, EE prevented hippocampal Iba-1 increased expression. EE-exposed mice presented increased hippocampal DCX expression. In addition, hippocampal demethylation of the SLC6A4 gene (serotonin transporter), an epigenetic reprogramming mechanism, was observed in the two-hit group submitted to EE. Our results reveal the preventive effects of long-term EE in mice exposed to the two-hit model of schizophrenia by mechanisms related to increased neurogenesis, reduced microglia reactivity, and epigenetic regulation of serotonergic signaling.
A combined model using pre-treatment CT radiomics and clinicopathological features of non-small cell lung cancer to predict major pathological responses after neoadjuvant chemoimmunotherapy
Authors: wang fang , yang hong , chen wujie , ruan lei , jiang tingting , jiang haitao , fang min 
Published: May 2023

Abstract

Objective: To explore the correlation between clinicopathology, CT radiomics and major pathologic response of NSCLC after neoadjuvant chemoimmunotherapy, and to establish a combined model to predict MPR.
Methods: The clinicopathological characteristics of NSCLC patients who received neoadjuvant chemoimmunotherapy in our hospital from January 2019 to April 2021 were retrospectively collected, and pre-treatment CT Radscore was calculated through standard radiomics workflow. Afterward, independent factors were screened, odds ratios were calculated, and a nomogram for predicting MPR was constructed. ROC curves were plotted for models. Finally, the three models were compared using Delong's test.
Results: 211 NSCLC patients were enrolled in this study. Radscore and RECIST assessment results were independent factors for MPR using multivariate logistic regression analysis. The AUC of the combined model was 0.76 (95% CI: 0.68-0.84) in training group, and 0.80 (95% CI: 0.67-0.92) in validation group. Delong's test showed that the AUC of the combined model was significantly different from the radiomics model alone in the training group (p = 0.0067) and also in the validation group (P=0.0009). The calibration curve showed that the predicted MPR was significantly close to the actual MPR of the patient, and the clinical decision curve indicated that the combined model had a higher overall net benefit than the radiomics model alone.
Conclusions: The combined model based on pre-treatment CT radiomics and clinicopathological features showed better predictive power than the independent radiomics model or the independent clinicopathological features, which may better guide the personalized neoadjuvant chemoimmunotherapy treatment strategy.
WITHDRAWN: Microbial life-history strategies in soils under long-term fertilizations
Authors: Wang Xiu , Dai Zhongmin , Lin Jiahui , Zhao Kankan , Brookes Philip C. , Barberán Albert , Kuzyakov Yakov , Xu Jianming 
Published: May 2023

Abstract
Background: The rRNA operon (rrn) copy number is associated with protein synthesis and reproduction, reflecting microbial r- and K-life strategies and influencing soil ecosystem function. Although the positive relationship between microbial community-level rrn copy numbers and nutrient availability has been reported, the association between rrn copy number and soil stoichiometry or environmental stress remains largely unknown, particularly in the context of long-term nutrient inputs.
Results: Using long-term (> 30 years) field experiments across three agro-ecosystems, we consistently found that N fertilization increased the microbial community-level rrn copy number. This increase was equivalently explained by soil CN stoichiometry (22%) and soil acidification (21%). Balanced soil CN stoichiometry favored the growth of N-dependent copiotrophs such as Bacilliand Flavobacteriia containing high rrn copy numbers (an average of 2.5), and enhanced their nutrient competition ability. Moreover, N fertilization-induced soil acidification, as an environmental stressor, increased the abundance of pH-negative responders such as Clostridia and Ktedonobacteria which also contained high rrn copy numbers (2.8), and threatened rare taxa with low rrn copy numbers.
Conclusions: Consequently, our finding challenges the concept of microbial life-strategy regulation solely by nutrient availability, highlighting the novelty of significant contributions of soil stoichiometric balance and environmental stress to microbial strategies in agro-ecosystems under long-term nutrient inputs.
Rare origin and course of the sinoatrial nodal artery: a cadaveric case report
Authors: Madeira M. Dulce , Pinto Filipe F. , Pereira Pedro A. 
Published: May 2023

Abstract
Purpose
Several previous studies reported variations in the origin and course of the sinoatrial nodal artery (SANa). In the present report, we describe a rare variation in the origin, course and relations of the SANa.
Methods
The case herein described was found during a routine dissection performed on a formalin-embalmed human adult male cadaver (82 years old).
Results
During the dissection, we identified the SANa originating from the right coronary artery (RCA) at the level of the inferior border (acute margin) of the heart and coursing upward. The initial part of this vessel is tortuous, and then it follows a straight path parallel to the RCA along the anterior surface of the right atrium. After this part, the artery curves posteriorly and to the left until it reaches the lower border of the right auricle, where it closely approaches the RCA. Finally, the artery runs posteriorly and to the right to follow a course along the medial wall of the right auricle and right atrium to reach a location close to the region of the junction of the superior vena cava and right atrium where it follows its path buried in the myocardium. We also characterized the artery radiologically through the injection of a contrast medium into the RCA and in the SANa.
Conclusion
The knowledge of the anatomical variations of the SANa is of the utmost importance for cardiologists and heart surgeons in order to better understand cardiac disease and accurately plan and execute cardiac interventions and surgical procedures.
Influence of Acculturation and Cultural Values on the Self-Reference Effect
Authors: Gilliam Ashley N. , Gutchess Angela 
Published: May 2023

Abstract
Cultural milieu can influence the way information is processed and what strategies are employed to deal with ever-changing environments. This study assessed whether acculturation and cultural values of East Asians can affect memory, with a specific focus on the self-reference effect in Chinese international students. Participants encoded and retrieved adjectives, with some trials relating the words to the self (i.e., the self-referencing task), another person, or a control condition; participants also completed questionnaires assessing cultural adaptation and self-construal. Results did not show a relationship between acculturation orientation and self-construal and the magnitude of the self-reference effect in memory, defined as better memory for adjectives encoded related to the self compared to those related to close others, in this sample of Chinese international students. Future research should explore effects of acculturation over time, incorporating more heterogeneous samples and sensitive neural measures.
Maintaining the Permanence Principle of Death During Normothermic Regional Perfusion in Controlled Dcd: Results of a Prospective Clinical Study
Authors: Royo-Villanova Mario , Miñambres Eduardo , Sánchez José Moya , Torres Eduardo , Manso Clara , Ballesteros María Ángeles , Parrilla Guillermo , Tudela Gonzalo De Paco , Coll Elisabeth , Pérez-Blanco Alicia , Domínguez-Gil Beatriz 
Published: May 2023

Abstract
Purpose
The use of normothermic regional perfusion (NRP) in donation after the circulatory determination of death (DCD) is limited by concerns associated with the reestablishment of circulation after death declaration. The aim of this study is to confirm that certain technical maneuvers applied during NRP preclude circulation to the brain.
Methods
A non-randomized trial was performed at two Spanish centers. Consecutive adult controlled DCD donors were included. In abdominal NRP (A-NRP), the thoracic aorta was blocked with an intra-aortic occlusion balloon. In thoraco-abdominal NRP (TA-NRP), the arch vessels were clamped and the cephalad ends vented to the atmosphere. Blood from the vented arch vessels drained to the thorax. The mean intracerebral arterial blood pressure (ICBP) was invasively measured at the circle of Willis.
Results
Ten cDCD donors subject to A-NRP (n = 8) and TA-NRP (n = 2) were included. Mean ICBP and mean blood pressure at the thoracic and the abdominal aorta during the circulatory arrest were 16.9 (SD:3.0), 17.2 (SD:3.0) and 17.6 (SD:4.4), respectively. When A-NRP was started, pressure at the abdominal aorta increased to 49.9 (SD:12.5) mmHg, while the ICBP remained unchanged. When TA-NRP was initiated, pressure at the thoracic aorta reached values of 70.5 (SD:17.7) mmHg, but the ICBP remained unmodified. Registered values of ICBP during NRP were 10 mmHg.
Conclusion
Appropriate technical measures applied during NRP preclude circulation to the brain in DCD procedures. This study can help to expand NRP, respecting the dead donor rule and increasing the number and quality of organs available for transplantation.
Unprecedented mortality induced by extreme hot-drought in mature planted Pinus spp stands is locally modulated by soil characteristics
Authors: Gatica Gabriel , Gyenge Javier , Bulfe Nardia María Luján , Pahr Norberto , Tea Fernando Dalla , Fernández María Elena 
Published: May 2023

Abstract
Increased tree mortality associated with hotter-drought events has rarely been recorded in mature commercial plantations. However, we report a recent (2021-2022 warm season) event of this kind that occurred across the Mesopotamian region of Argentina, South America. We aimed to elucidate the mortality timing, rate, and magnitude associated with environmental and stand characteristics at local scale to determine which conditions make these productive systems more vulnerable to extreme climatic events. Using Sentinel-2 satellite images and field-data we estimated the canopy mortality from November 2021 to October 2022, in Pinus spp afforestations (mainly P. taeda). We found that spatio-temporal heterogeneity in canopy mortality was associated with variation in soil and topographic characteristics, but not in stand age and size. Highest-extent, earlier, and advancing faster canopy mortality was observed in shallow soils, while the lowest mortality occurred at depressed and waterlogged areas. Intermediate levels of mortality were observed in deep soils (>1 m), where relatively higher mortality occurred in areas with shallow water table signs, inhibiting deep root development. Our results suggest that sites allowing a deeper rooting system and/or where soil water availability is expected to be higher and long-lasting could represent areas with low-mortality risk for fast-growing pine plantations.
Preoperatively Predict the Minimum Autograft Length Necessary for Reconstructive Surgery of the Posterolateral Corner: A Cadaveric Study.
Authors: Novák Pavel , Raška Otakar , Kuběna Aleš Antonín , Mazura Matěj , Hromádka Rastislav 
Published: May 2023

Abstract
Background: The study aimed to find a correlation between the anthropometric values measurable on X-ray and the necessary length of the graft required for reconstructive surgery of lateral collateral structures-the modified LaPrade reconstruction surgery with single-point femoral fixation.
Methods: The study included 25 cadaveric bodies, forty lower extremities. Standard anatomical dissection techniques were used. Chosen bone parameters were measured and on the identical lower limbs a reconstruction procedure was performed. Portions of the grafts were measured and statistically analysed.
Results: An association between lateral femoral condyle distance and total graft length was found, allowing us to assemble a formula, which provides surgeons to calculate a minimal graft length needed for a complete LaPrade reconstruction surgery with a single-point femoral fixation modification.
Conclusions: Our formula should help decide whether it is possible to use an autograft, where to take the autograft from, and possibly adjust the surgical technique accordingly. A great advantage of the formula is its use based on a preoperative X-ray image.
Level of Evidence: II-III
Differential Expression of Cyclin D-1 in Pituitary Adenoma: Relation to Aggressive Potential
Authors: Uchime Kasiemobi Eberechukwu , Awolola Nicholas Awodele , Charles Anunobi Chidozie , Park Sung-Hye , Bankole Olufemi B. , Banjo Adekunbiola A.F. 
Published: May 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
The Impact of the COVID-19 Pandemic on Clostridioides Difficile Infection Outcomes and Disparities in Care in New York City
Authors: Jesus Gabrielle Hernaiz-De , Zhang Joyce L. , Birhanu Beselot , Grinspan Ari 
Published: May 2023

Abstract
Purpose Social determinants and comorbid conditions are known to influence Clostridioides Difficile infection (CDI) outcomes. The COVID-19 pandemic exacerbated overall health care disparities, and although CDI rates were stable if not lower, patients with CDI had worsened morbidity and mortality. Our purpose is to study the effect of social factors and recently resolved or concomitant COVID-19 infection on CDI outcomes in a metropolitan health system during the pandemic.Methods This was a retrospective, logistic regression of 338 patients extracted from a database of hospitalized patients with CDI at a tertiary urban center in New York City between April 2020 and October 2021. The primary endpoint was severity of infection, and secondary endpoints were intensive care stay and length of hospitalization as well as CDI recurrence, mortality and colectomy within one year.Results Patients insured under Medicaid were more likely to experience mortality during admission (UOR = 2.66, AOR = 3.45, 95%CI: 1.43, 8.29), while all publicly insured patients had higher 1 year mortality (UOR = 2.43, AOR = 2.71, 95%CI: 1.21, 6.06). Concomitant COVID and CDI was associated with severe or fulminant infection (53.8% vs. 84.6%, p = 0.03) compared to no COVID, with no difference in mortality (13.4% vs. 18.2%, p = 0.65).Conclusion There were demographic and insurance-based disparities in CDI care. While patients with concomitant COVID had more severe or fulminant infections, there was no difference in mortality in these patient groups as would have been expected based on severity classification.
An Integrative Literature Review: The Dual Impact of Technological Tools on Health and Technostress Among Older Workers
Authors: Nedeljko Mihael , Gu Yang , Bostan Cristina Maria 
Published: May 2023

Abstract

Introduction: The global population is ageing, life expectancy is gradually increasing, and employment is extended. We wanted to use an integrative literature review to study how using technological tools improves the quality of working life among older workers.
Methods: The integrative literature review method following PRISMA guidelines was used. The selection of articles in English was made according to the following inclusion criteria: scientific papers, content relevance and topicality. The literature search covered the bibliographic-catalogue databases Web of Science, PubMed, and Scopus. After selection, a qualitative content analysis was applied to the data.
Results: From the initial twelve articles, we gained insight into how using technological tools impacts the quality of working life among older workers through a substantive analysis of twelve scientific articles. Two content categories were identified: health of older workers and technostress. Regarding the impact on health, studies have focused on various health outcomes like sleeping quality, mental health, workability arthritis as a chronic condition, physical and quality of life in older community-dwelling low-income, diet, physical activity, stress and tobacco use, stress, and job quality. Studies regarding technostress that we identified show mixed effects of significant and non-significant effects.
Discussion: Digital technologies can potentially improve the quality of working life among older workers but are currently under-researched. Further research is needed to develop effective interventions and evaluate their impact on the quality of life of older workers.