bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong decays of $$ {P}_{\psi}^N{(4312)}^{+} $$ to J/ψ(ηc)p and $$ {\overline{D}}^{\left(\ast \right)}{\Lambda}_c $$ within the Bethe-Salpeter framework
Authors: Li Qiang , Chang Chao-Hsi , Wang Tianhong , Wang Guo-Li 
Published: June 2023

Abstract
Based on the effective Lagrangian in the heavy quark limit, we calculate the one-boson-exchange interaction kernel of $$ {P}_{\psi}^N{(4312)}^{+} $$

P
ψ
N

4312

+

as the $$ \overline{D}{\Sigma}_c $$

D
¯

Σ
c

molecular state in isospin-$$ \frac{1}{2} $$

1
2

. We present the Bethe-Salpeter equation and wave function for the constituent particles to be a (pseudo)scalar meson and a $$ \frac{1}{2} $$

1
2

baryon. By solving the Bethe-Salpeter equation, we obtain $$ {P}_{\psi}^N{(4312)}^{+} $$

P
ψ
N

4312

+

as the $$ \overline{D}{\Sigma}_c $$

D
¯

Σ
c

molecular state with JP = $$ {\left(\frac{1}{2}\right)}^{-} $$

1
2

−

. Combining the effective Lagrangian and the obtained BS wave function, the partial decay widths of $$ {P}_{\psi}^N{(4312)}^{+} $$

P
ψ
N

4312

+

to J/ψp, ηcp, $$ {\overline{D}}^{\ast 0}{\Lambda}_c^{+} $$

D
¯

∗
0

Λ
c
+

and $$ {\overline{D}}^0{\Lambda}_c^{+} $$

D
¯

0

Λ
c
+

are calculated to be 0.17, 0.085, 8.8, and 0.026 MeV, respectively, which are roughly consistent with the LHCb experimental measurements and some other theoretical researches. The obtain results indicate the fraction of $$ {\overline{D}}^{\ast 0}{\Lambda}_c^{+} $$

D
¯

∗
0

Λ
c
+

channel amounts to ~ 90% of $$ {P}_{\psi}^N{(4312)}^{+} $$

P
ψ
N

4312

+

, and is a highly promising channel to be discovered in the near future experiments. Our results favor the interpretation of $$ {P}_{\psi}^N{(4312)}^{+} $$

P
ψ
N

4312

+

as the $$ \overline{D}{\Sigma}_c $$

D
¯

Σ
c

molecular state with JP = $$ {\left(\frac{1}{2}\right)}^{-} $$

1
2

−

and isospin I = $$ \frac{1}{2} $$

1
2

.
The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells
Authors: Luostarinen Samu , Hämäläinen Mari , Pemmari Antti , Moilanen Eeva 
Published: June 2023

Abstract
Background
Transient Receptor Potential Ankyrin 1 (TRPA1) is a cation channel that mediates pain, itch, cough, and neurogenic inflammation in response to pungent compounds such as acrolein in cigarette smoke. TRPA1 is also activated by endogenous factors and promotes inflammation in asthma models. We have recently shown that TRPA1 is upregulated by inflammatory cytokines in A549 human lung epithelial cells. Here, we explored the effects of Th1 and Th2-type inflammation on TRPA1.

Methods and results
TRPA1 expression and function was studied in A549 human lung epithelial cells. To induce inflammation, the cells were exposed to a combination of cytokines TNF-α and IL-1β; and to model Th1 or Th2-type responses, IFN-γ or IL-4/IL-13 was added, respectively. TRPA1 expression (measured by RT-PCR and Western blot) and function (assessed by Fluo-3AM intracellular calcium measurement) was enhanced under the influence of TNF-α + IL-1β. IFN-γ further enhanced TRPA1 expression and function, whereas IL-4 and IL-13 suppressed them. The effects of IFN-γ and IL-4 on TRPA1 expression were reversed by the Janus kinase (JAK) inhibitors baricitinib and tofacitinib, and those of IL-4 also by the STAT6 inhibitor AS1517499. The glucocorticoid dexamethasone downregulated TRPA1 expression, whereas the PDE4 inhibitor rolipram had no effect. Under all conditions, TRPA1 blockade was found to reduce the production of LCN2 and CXCL6.

Conclusions
TRPA1 expression and function in lung epithelial cells was upregulated under inflammatory conditions. IFN-γ further increased TRPA1 expression while IL-4 and IL-13 suppressed that in a JAK-STAT6 dependent manner which is novel. TRPA1 also modulated the expression of genes relevant to innate immunity and lung disease. We propose that the paradigm of Th1 and Th2 inflammation is a major determinant of TRPA1 expression and function, which should be considered when targeting TRPA1 for pharmacotherapy in inflammatory (lung) disease.
Möglichkeiten der funktionellen Bildgebung bei Tinnitus
Authors: Isler Benjamin , Neff Patrick , Kleinjung Tobias 
Published: June 2023

Zusammenfassung
Hintergrund
Die Pathophysiologie des Tinnitus ist nach wie vor nicht ausreichend verstanden. Verschiedene Bildgebungsmethoden helfen beim besseren Verständnis der komplexen Zusammenhänge, die zur Wahrnehmung von Tinnitus führen.

Ziel der Arbeit
Es erfolgt die Vorstellung von verschiedenen funktionellen Bildgebungsmethoden, die in der Erforschung von Tinnitus eingesetzt werden können.

Material und Methoden
Unter Einbezug der aktuellen Fachliteratur zum Thema gehen die Autoren auf die relevanten Bildgebungsmethoden der Tinnitusforschung ein.

Ergebnisse und Schlussfolgerung
Die funktionelle Bildgebung kann Korrelate von Tinnitus aufzeigen. Aufgrund der noch eingeschränkten zeitlichen und räumlichen Auflösung der aktuellen Bildgebungsmodalitäten lässt eine abschließende Erklärung von Tinnitus auf sich warten. Mit der weiteren Verbreitung der funktionellen Bildgebung lassen sich in Zukunft zusätzliche wichtige Erkenntnisse zur Aufklärung von Tinnitus gewinnen.
Topological Modular Forms and the Absence of All Heterotic Global Anomalies
Authors: Tachikawa Yuji , Yamashita Mayuko 
Published: June 2023

AbstractWe reformulate the question of the absence of global anomalies of heterotic string theory mathematically in terms of a certain natural transformation $$\text {TMF} ^\bullet \rightarrow (I_\mathbb {Z}\Omega ^{\text {string} })^{\bullet -20}$$

TMF
∙

→

(

I
Z

Ω
string

)

∙
-
20

, from topological modular forms to the Anderson dual of string bordism groups, using the Segal–Stolz–Teichner conjecture. We will show that this natural transformation vanishes, implying that heterotic global anomalies are always absent. The fact that $$\text {TMF} ^{21}(\text {pt} )=0$$

TMF
21

(
pt
)

=
0

plays an important role in the process. Along the way, we also discuss how the twists of $$\text {TMF} $$
TMF
can be described under the Segal–Stolz–Teichner conjecture, by using the result of Freed and Hopkins concerning anomalies of quantum field theories. The paper contains separate introductions for mathematicians and for string theorists, in the hope of making the content more accessible to a larger audience. The sections are also demarcated cleanly into mathematically rigorous parts and those which are not.
Micelle structure of nonionic surfactants containing carbon dioxide moieties in protic ionic liquids
Authors: Miao Shurui , Gradzielski Michael , Warr Gregory 
Published: June 2023

AbstractPartial substitution of ethylene oxide with carbon dioxide moieties can yield greener nonionic surfactants with comparable functionalities. In water, studies showed that the incorporation of CO2 moieties suppresses the formation of liquid crystalline phases at high concentrations. A similar reduction in solvation and suppression of liquid crystal formation is observed here in the ionic liquids ethylammonium nitrate and propylammonium nitrate. Small-angle neutron scattering is used to study the solvation and packing of micelles in ionic liquids as functions of temperature, concentration, and content of CO2 moieties. By comparing with aqueous solutions, this work shows that while the nature of surfactant-solvent interaction is comparable among water and alkylammonium nitrate ILs, their behaviours in the solvated micelle shell are different. The lack of liquid crystalline phases should be attributed to the small excluded volume of micelles, which can be fine-tuned via ion design and choice of solvent.
Graphical Abstract
The added value of spinal cord lesions to disability accrual in multiple sclerosis
Authors: Ruggieri Serena , Prosperini Luca , Petracca Maria , Logoteta Alessandra , Tinelli Emanuele , De Giglio Laura , Ciccarelli Olga , Gasperini Claudio , Pozzilli Carlo 
Published: June 2023

AbstractSpinal cord MRI is not routinely performed for multiple sclerosis (MS) monitoring. Here, we explored whether spinal cord MRI activity offers any added value over brain MRI activity for clinical outcomes prediction in MS. This is a retrospective, monocentric study including 830 MS patients who underwent longitudinal brain and spinal cord MRI [median follow-up 7 years (range: < 1–26)]. According to the presence (or absence) of MRI activity defined as at least one new T2 lesion and/or gadolinium (Gd) enhancing lesion, each scan was classified as: (i) brain MRI negative/spinal cord MRI negative; (ii) brain MRI positive/spinal cord MRI negative; (iii) brain MRI negative/spinal cord MRI positive; (iv) brain MRI positive/spinal cord MRI positive. The relationship between such patterns and clinical outcomes was explored by multivariable regression models. When compared with the presence of brain MRI activity alone: (i) Gd + lesions in the spine alone and both in the brain and in the spinal cord were associated with an increased risk of concomitant relapses (OR = 4.1, 95% CI 2.4–7.1, p < 0.001 and OR = 4.9, 95% CI 4.6–9.1, p < 0.001, respectively); (ii) new T2 lesions at both locations were associated with an increased risk of disability worsening (HR = 1.4, 95% CI = 1.0–2.1, p = 0.05). Beyond the presence of brain MRI activity, new spinal cord lesions are associated with increased risk of both relapses and disability worsening. In addition, 16.1% of patients presented asymptomatic, isolated spinal cord activity (Gd + lesions). Monitoring MS with spinal cord MRI may allow a more accurate risk stratification and treatment optimization.
Comparison of visual outcomes in adult patients with different types of developmental cataracts after toric multifocal intraocular lenses implantation
Authors: Shen Jiying , Ma Dongmei , Cai Lei , Zhang Limei , Guo Haike , Yang Jin 
Published: June 2023

Abstract
Purpose
To analyze and compare the visual performance and patient satisfaction following the implantation of toric multifocal intraocular lenses (TMIOLs) in adult patients with different types of developmental cataracts (DC) accompanied by corneal astigmatism (CA).

Methods
This is a prospective observational cohort study. Patients diagnosed with DC aged 18–30 years were divided into three groups according to the anatomic location of the lens opacity: cortical, nuclear, and posterior subcapsular (PSC) groups, and implanted with TMIOLs. Visual acuity (VA), postoperative refractive astigmatism (RA), intraocular lens (IOL) rotation, high-order aberrations (HOAs), modulation transfer function (MTF) curve, and Strehl ratio were compared. The functional vision and incidence of photic phenomena were surveyed using questionnaires.

Results
Fifty-five eyes of 37 patients were enrolled and completed a 1-year follow-up. The mean CA was 2.06 ± 0.79 D preoperatively, and the mean RA was 0.29 ± 0.30 D 3-month postoperatively. The IOL rotation was 2.48° ± 1.89°, with no deviation > 10°. At 12 months, mean uncorrected distance VA improved from 0.93 ± 0.41 preoperatively to 0.08 ± 0.08 logarithm of the minimum angle of resolution (logMAR), mean uncorrected near VA increased from 0.45 ± 0.30 preoperatively to 0.12 ± 0.11 logMAR, and mean uncorrected intermediate VA was 0.14 ± 0.08 logMAR. The cortical and nuclear groups displayed better improvements in uncorrected near and intermediate VA than that in the PSC group. Similar results were observed in the 3-month defocus curves, HOAs, MTF curve, halo incidence, and near vision satisfaction.

Conclusion
In adult patients with DC accompanied by CA, TMIOLs implantation achieved good postoperative visual outcomes and significantly reduced glasses dependency. Patients with cortical or nuclear lens opacity showed better whole-course VA and quality of vision, while patients with PSC opacity showed unsatisfactory near vision and suffered more photic phenomena.
Benchmarking outcomes for distal pancreatectomy: critical evaluation of four multicenter studies
Authors: Müller P. C. , Toti J. M. A. , Guidetti C. , Kuemmerli C. , Bolli M. , Billeter A. T. , Müller B. P. 
Published: June 2023

Abstract
Background
Benchmarking is a validated tool for outcome assessment and international comparison of best achievable surgical outcomes. The methodology is increasingly applied in pancreatic surgery and the aim of the review was to critically compare available benchmark studies evaluating distal pancreatectomy (DP).

Methods
A literature search of English articles reporting on benchmarking DP was conducted of the electronic databases MEDLINE and Web of Science (until April 2023). Studies on open (ODP), laparoscopic (LDP), and robotic DP (RDP) were included.

Results
Four retrospective multicenter studies were included. Studies reported on outcomes of minimally invasive DP only (n = 2), ODP and LDP (n = 1), and RDP only (n = 1). Either the Achievable Benchmark of Care™ method or the 75th percentile from the median was selected to define benchmark cutoffs. Robust and reproducible benchmark values were provided by the four studies for intra- and postoperative short-term outcomes.

Conclusion
Benchmarking DP is a valuable tool for obtaining internationally accepted reference outcomes for open and minimally invasive DP approaches with only minor variances in four international cohorts. Benchmark cutoffs allow for outcome comparisons between institutions, surgeons, and to monitor the introduction of novel minimally invasive DP techniques.
Optimal execution with multiplicative price impact and incomplete information on the return
Authors: Dammann Felix , Ferrari Giorgio 
Published: June 2023

AbstractWe study an optimal liquidation problem with multiplicative price impact in which the trend of the asset price is an unobservable Bernoulli random variable. The investor aims at selling over an infinite time horizon a fixed amount of assets in order to maximise a net expected profit functional, and lump-sum as well as singularly continuous actions are allowed. Our mathematical modelling leads to a singular stochastic control problem featuring a finite-fuel constraint and partial observation. We provide a complete analysis of an equivalent three-dimensional degenerate problem under full information, whose state process is composed of the asset price dynamics, the amount of available assets in the portfolio, and the investor’s belief about the true value of the asset’s trend. Its value function and optimal execution rule are expressed in terms of the solution to a truly two-dimensional optimal stopping problem, whose associated belief-dependent free boundary $b$
b
triggers the investor’s optimal selling rule. The curve $b$
b
is uniquely determined through a nonlinear integral equation, for which we derive a numerical solution through an application of the Monte Carlo method. This allows us to understand the value of information in our model as well as the sensitivity of the problem’s solution with respect to the relevant model parameters.
Accuracy of maxillary positioning using computer-designed and manufactured occlusal splints or patient-specific implants in orthognathic surgery
Authors: Malenova Yoana , Ortner Florian , Liokatis Paris , Haidari Selgai , Tröltzsch Matthias , Fegg Florian , Obermeier Katharina T. , Hartung Jens T. , Kakoschke Tamara K. , Burian Egon , Otto Sven , Sabbagh Hisham , Probst Florian A. 
Published: June 2023

Abstract
Objective
To determine the accuracy of maxillary positioning using computer-designed and manufactured occlusal splints or patient-specific implants in orthognathic surgery.

Material and Methods
A retrospective analysis of 28 patients that underwent virtually planned orthognathic surgery with maxillary Le Fort I osteotomy either using VSP-generated splints (n = 13) or patient-specific implants (PSI) (n = 15) was conducted. The accuracy and surgical outcome of both techniques were compared by superimposing preoperative surgical planning with postoperative CT scans and measurement of translational and rotational deviation for each patient.

Results
The 3D global geometric deviation between the planned position and the postoperative outcome was 0.60 mm (95%-CI 0.46–0.74, range 0.32–1.11 mm) for patients with PSI and 0.86 mm (95%-CI 0.44–1.28, range 0.09–2.60 mm) for patients with surgical splints.
Postoperative differences for absolute and signed single linear deviations between planned and postoperative position were a little higher regarding the x-axis and pitch but lower regarding the y- and z-axis as well as yaw and roll for PSI compared to surgical splints.
There were no significant differences regarding global geometric deviation, absolute and signed linear deviations in the x-, y-, and z-axis, and rotations (yaw, pitch, and roll) between both groups.

Conclusions
Regarding accuracy for positioning of maxillary segments after Le Fort I osteotomy in orthognathic surgery patient-specific implants and surgical splints provide equivalent high accuracy.

Clinical relevance
Patient-specific implants for maxillary positioning and fixation facilitate the concept of splintless orthognathic surgery and can be reliably used in clinical routines.
Analysis of the tip interference in low gear ratio internal spur gears with profile modification
Authors: Pedrero José I. , Pleguezuelos Miguel , Sánchez Miryam B. 
Published: June 2023

AbstractThis paper presents a discussion on the influence of the tip relief on the tip interference and contact ratio, as well as a methodology to select proper values of the teeth heights, center distances, rack shift coefficients, and tip reliefs to ensure maximum values of the contact ratio while avoiding tip interference, root interference and pitch interference. The influence of the quasi-static transmission error on the tip interference is also considered in the analysis.
Watch brain circulation in unexplained progressive myelopathy: a review of Cognard type V arterio-venous fistulas
Authors: De Grado Amedeo , Manfredi Chiara , Brugnera Agostino , Groppo Elisabetta , Valvassori Luca , Cencini Federica , Erbetta Alessandra , Ciceri Elisa , Lerario Rosanna , Priori Alberto , Scelzo Emma 
Published: June 2023

Abstract

Background
Intracranial dural arterio-venous fistulas are pathological anastomoses between arteries and veins located within dural sheets and whose clinical manifestations depend on location and hemodynamic features. They can sometimes display perimedullary venous drainage (Cognard type V fistulas—CVFs) and present as a progressive myelopathy. Our review aims at describing CVFs’ variety of clinical presentation, investigating a possible association between diagnostic delay and outcome and assessing whether there is a correlation between clinical and/or radiological signs and clinical outcomes.

Methods
We conducted a systematic search on Pubmed, looking for articles describing patients with CVFs complicated with myelopathy.

Results
A total of 72 articles for an overall of 100 patients were selected. The mean age was 56.20 ± 14.07, 72% of patients were man, and 58% received an initial misdiagnosis. CVFs showed a progressive onset in 65% of cases, beginning with motor symptoms in 79% of cases. As for the MRI, 81% presented spinal flow voids. The median time from symptoms’ onset to diagnosis was 5 months with longer delays for patients experiencing worse outcomes. Finally, 67.1% of patients showed poor outcomes while the remaining 32.9% obtained a partial-to-full recovery.

Conclusions
We confirmed CVFs’ broad clinical spectrum of presentation and found that the outcome is not associated with the severity of the clinical picture at onset, but it has a negative correlation with the length of diagnostic delay. We furthermore underlined the importance of cervico-dorsal perimedullary T1/T2 flow voids as a reliable MRI parameter to orient the diagnosis and distinguish CVFs from most of their mimics.
Automated image-based generation of finite element models for masonry buildings
Authors: Pantoja-Rosero Bryan German , Achanta Radhakrishna , Beyer Katrin 
Published: June 2023

AbstractTo predict the response of masonry buildings to various types of loads, engineers use finite element models, specifically solid-element and macro-element models. For predicting masonry responses to seismic events in particular, equivalent frame models—a subcategory of macro-element models—are a common choice because of their low computational cost. However, an existing bottleneck in modeling pipelines is generating the geometry of the model, which is currently a slow and laborious process that is done manually using computer-aided design tools. In this paper, we address this by automating the modelling process using recent advancements in computer vision and machine learning. We present an image-based end-to-end pipeline that automatically generates finite element meshes for solid-element and equivalent-frame models of the outer walls of free-standing historical masonry buildings. As the input, our framework requires RGB images of the buildings that are processed using structure-from-motion algorithms, which create 3D geometries, and convolutional neural networks, which segment the openings and their corners. These layers are then combined to generate level of detail models. We tested our pipeline on structures with irregular surface geometries and opening layouts. While generating the solid element mesh from the level of detail model is straightforward, generating equivalent frame models required algorithms for segmenting the façade and the meshing. Experts in the field analyzed the generated equivalent frame models and determined them to be useful for numerical modeling. These finite element geometries will be invaluable for future predictions of the seismic response of damaged and undamaged buildings. The codes and dataset are publicly available for future studies and benchmarking (https://github.com/eesd-epfl/FEM_buildings and https://doi.org/10.5281/zenodo.8094306).
Factors associated with treatment adherence to mandibular advancement devices: a scoping review
Authors: van der Hoek Liselotte H. , Rosenmöller Boudewijn R.A.M. , van de Rijt Liza J.M. , de Vries Ralph , Aarab Ghizlane , Lobbezoo Frank 
Published: June 2023

Abstract
Purpose
Obstructive sleep apnea (OSA) is frequently treated with continuous positive airway pressure (CPAP) or mandibular advancement devices (MADs). For various reasons, both treatment options are often affected by low adherence. While factors associated with low CPAP adherence are described in the literature extensively, less is known about adherence to MAD therapy. This scoping review aimed to synthesize the body of literature on the factors associated with adherence to MAD treatment.

Methods
A systematic literature search was conducted using bibliographic databases PubMed, Embase.com, Web of Science, and the Cochrane Library (Wiley) to identify relevant studies that described factors associated with adherence to MAD in the treatment of OSA or snoring combined with OSA in adults.

Results
The literature search yielded a total of 694 references. Forty studies were found eligible for inclusion. The literature showed that factors with a possible negative influence on the adherence to MAD treatment are personality aspects; failing effectiveness of MAD; side effects during MAD therapy; using a thermoplastic MAD; dental treatments during MAD therapy; and a poor first experience with the MAD with inadequate guidance by professionals. Factors that may have a positive effect on MAD adherence include effectiveness of therapy, custom-made MAD, good communication skills of the practitioner, early recognition of side effects, stepwise titration of the MAD, and positive first experience with MAD.

Conclusions
The knowledge of factors associated with MAD adherence can be used to provide further insight into individual adherence to OSA treatments.