bluuebunny/crossref_metadata_2025_split huggingface dataset:
Использование флокулянтов для очистки сточных вод
Authors: Ulrich Elena V. , Barkova A.S. 
Published: March 2023

Polymeric flocculants are used to accelerate the separation of solid and liquid phases in the treatment of drinking water and wastewater. Recently, much attention has been paid to flocculants, both synthetic and biobased, due to their advantages for wastewater treatment processes. Flocculants have many advantages such as biodegradability, non-toxicity, the ability to undergo various chemical modifications, and wide availability from renewable sources. This article provides a review of synthetic and biobased flocculants and lists their potential applications in water treatment. Based on the up-to-date data, a new approach is proposed for searching for modified and grafted flocculants, flocculation mechanisms, test methods, and factors influencing this process. Particular attention is paid to flocculants based on chitosan and its derivatives, since they are cheap and environmentally friendly materials used in industrial practice. Keywords: polymers, chitosan, flocculation, bridging, neutralization, environment
Полимерные флокулянты используются для ускорения процессов разделения твердой и жидкой фаз при очистке питьевой воды и сточных вод. В последнее время большое внимание уделяется флокулянтам как на синтетической, так и на биологической основе. Флокулянты обладают рядом преимуществ: биоразлагаемостью, нетоксичностью, способностью подвергаться различным химическим модификациям и широкой доступностью (в том числе флокулянтов, полученных из возобновляемых источников). В статье представлен обзор флокулянтов на синтетической и биологической основах, а также их потенциального применения при очистке воды. Основываясь на сведениях, отраженных в новейшей литературе, описан новационный подход к поиску модифицированных и привитых флокулянтов, механизмов флокуляции, методов испытаний, установлены факторы, влияющие на протекание этого процесса. Особое внимание уделено флокулянтам на основе хитозана и его производных, поскольку они являются дешевыми и экологичными материалами, используемыми в промышленной практике.
РЕСУРСНЫЙ ПОТЕНЦИАЛ РЕГИОНА И МЕТОДИЧЕСКИЕ ПОДХОДЫ К ОЦЕНКЕ ЕГО ЭФФЕКТИВНОГО ИСПОЛЬЗОВАНИЯ И УПРАВЛЕНИЯ
Authors: Миронова Елена 
Published: March 2023

В статье классифицируются различные теоретические взгляды российских и зарубежных регионалистов на определение таких важных понятий, как «регион», «ресурсы», «потенциал», «эффективность использования ресурсного потенциала». Раскрыта инструментальная база к оценке ресурсного потенциала региона с учётом затратного метода и доходного метода, с определением возможной капитализации дохода.
В ходе работы авторами доказано, чтобы оставаться конкурентоспособными и инновационными, регионы должны трансформировать свою экономику в сторону более высоких технологических укладов, уравновешивая структурные элементы своего ресурсного потенциала.
Авторау удалось обосновановать, что для оптимального использования ресурсов конкретного региона и эффективного управления ими необходимо поддерживать баланс между различными компонентами, составляющими его структуру.
SGLT2i alleviates epicardial adipose tissue inflammation by modulating ketone body–glyceraldehyde-3-phosphate dehydrogenase malonylation pathway
Authors: Li Lina , Hua Cuncun , Liu Xiaoyan , Wang Yidan , Zhao Lei , Zhang Yeping , Wang Li , Su Pixiong , Yang Min-Fu , Xie Boqia 
Published: March 2023

Aims
Inflammation in the epicardial adipose tissue (EAT) is a contributor to atrial fibrillation. Studies have reported that sodium glucose co-transporter 2 inhibitor (SGLT2i) can alleviate EAT inflammation. However, the mechanism remains elusive. This study aims to investigate the molecular mechanism of SGLT2i in reducing EAT inflammation and to explore the effects of SGLT2i on atrial fibrosis in atrial fibrillation.

Methods
Sprague–Dawley rats were injected with angiotensin II to induce atrial fibrillation and randomly assigned to receive SGLT2i (n = 6) or vehicle (n = 6). Macrophages (RAW264.7) were treated with ketone bodies; ACC1 knockdown/overexpression and malonyl-CoA overexpression were performed in vitro. The levels of inflammatory cytokines, ACC1, and malonyl-CoA were examined by ELISA. GAPDH malonylation was measured by co-immunoprecipitation.

Results
In atrial fibrillation rats, SGLT2i increased the ketone body levels and decreased the expression of ACC1 and alleviated EAT inflammation and atrial fibrosis. In RAW264.7 cells, ketone bodies decreased the levels of ACC1, malonyl-CoA, and GAPDH malonylation, accompanied by reduced inflammatory cytokines. ACC1 knockdown decreased the expression of malonyl-CoA and GAPDH malonylation and alleviated lipopolysaccharide (LPS)-induced macrophage inflammation; these effects were inhibited by malonyl-CoA overexpression. Furthermore, the protective effects of ketone bodies on macrophage inflammation were abrogated by ACC1 overexpression.

Conclusion
SGLT2i alleviates EAT inflammation by reducing GAPDH malonylation via downregulating the expression of ACC1 through increasing ketone bodies, thus attenuating atrial fibrosis.
Model Pemasaran untuk Meningkatkan Volume Penjualan Ekspor Udang Vaname (Litopenaeus Vannamei) : Studi Kasus UD. Jumari
Authors: Rivaldi Muhammad Adam , Jamil Muhammad , Supristiwendi  , Mahyuddin Thursina 
Published: March 2023

Tujuan dalam penelitian yaitu untuk menganalisis bagaimana strategi pemasaran dan strategi apakah yang paling tepat untuk meningkatkan penjualan ekspor udang vaname (Litopenaeus Vannamei) Pada UD. Jumari Kecamatan Gebang Kabupaten Langkat. Penentuan lokasi penelitian dilakukan secara studi kasus. Desain penelitian dilakukan dengan pendekatan deskriptif kualitatif yang dikuantitatifkan. Pendekatan deskriptif kualitatif ini mengunakan bauran pemasaran (product, price, place, promotion). Analisis data menggunakan analisis SWOT (Strenght, Weakness, Opportunity, Threat), dan analisis QSPM. Hasil penelitian menunjukkan nilai skor IFAS sebesar 2,93 menunjukkan posisi internal yang kuat, nilai skor EFAS sebesar 2,64 menunjukkan bahwa perusahaan merespon peluang dan menghindari ancaman-ancaman yang ada. Pada diagram Cartesius diketahui UD. Jumari berada pada kuadran I dan berada pada jalur yang tepat dengan melakukan strategi agresif. Strategi yang harus diterapkan oleh UD. Jumari adalah mendukung kebijakan pertumbuhan yang agresif (Growth Oriented Strategy). Pada matriks IE, UD. Jumari terletak pada sel 5, hasilnya perusahaan masuk kedalam fase growth yang berkonsentrasi melalui integrasi horizontal dan stability yaitu tidak ada perubahan profit strategi. Matriks SWOT, perusahaan berada pada kotak SO. Prioritas strategi pemasaran yang diperoleh dari hasil analisis dengan menggunakan matriks QSPM adalah Memanfaatkan kualitas udang dan sertifikasi dari kementerian kelautan dan perikanan Indonesia yang dimiliki oleh UD. Jumari agar dapat memperluas pasar dan menjaga citra yang baik dikalangan konsumen untuk meningkatkan penjualan. Peneliti menyarankan UD. Jumari agar dapat tetap mempertahankan serta meningkatkan kualitas daripada udang UD. Jumari dan memperluas dan mengembangkan akses di pasar internasional maupun lokal agar dapat meningkatkan tingkat penjualan.
PENGELOLAAN BRANDING PERUSAHAAN DI MEDIA SOSIAL MELALUI PENDEKATAN CONTENT MARKETING
Authors: Siregar Falaah Saputra , Purnama Hadi , Parsono Slamet 
Published: March 2023

As a newly established company, Etapasbar is aiming to further increasing their brand awareness and branding to customers and Pasar Baru Bandung Merchant. Etapasbar chose to use instagram @etalasepasarbaru as the main social media to communicate with the audience. This research is done to find out how do Etapasbar manage company branding by using content marketing approach in Instagram based on case study of Bahenol, Balantik, and Beja ti Pasbar. Bahenol, Balantik, and Beja ti Pasbar are three main content programs created for fulfilling the need of brand awareness and branding. This research object is the strategic and management of branding in Etapasbar. Data is collected by using interview and observation. Researcher will analyze the three main content programs based on observation then researcher will ask for futher indepth information of the programs. Discussion will be breakdown into three section, flow and strategic management of content, effort of increasing brand awreness, and building branding. This research resulting in the strategic formulation that is used by Etapasbar based on market segmentation, the attempt of increasing brand awareness is done by using attribute that is shown in the content in Instagram, Etapasbar branding is created and formed by satisfaction of customer and registered merchant at Etapasbar.
Keywords: content marketing, corporate branding, erapasbar, social media
Efficacy of fixed duration multidrug therapy for the treatment of multibacillary leprosy: A prospective observational study from Northern India
Authors: Singh Itu , Ahuja Madhvi , Lavania Mallika , Pathak Vinay K , Turankar Ravindra P , Singh Vikram , Sengupta Utpal , Das Loretta , Kumar Archana , Saini Geeta B 
Published: March 2023

Background:
In endemic regions of several countries, the prevalence of leprosy has not come down to the level of elimination. On the contrary, new cases are being detected in large numbers. Clinically, it is frequently noted that despite completion of multibacillary multidrug therapy for 12 months, the lesions remain active, especially in cases with high bacteriological indices.

Aim:
The present study focused on finding out the viable number of Mycobacterium leprae during the 12-month regimen of multibacillary multidrug therapy, at six and 12 months intervals and, attempting to determine their role in disease transmission.

Methods:
Seventy eight cases of multibacillary leprosy cases were recruited from leprosy patients registered at The Leprosy Mission hospitals at Shahdara (Delhi), Naini (Uttar Pradesh) and Champa (Chhattisgarh), respectively. Slit skin smears were collected from these patients which were transported to the laboratory for further processing. Ribonucleic acid was extracted by TRIzol method. Total Ribonucleic acid was used for real-time reverse transcription-polymerase chain reaction (two-step reactions). A standard sample with a known copy number was run along with unknown samples for a reverse transcription-polymerase chain reaction. Patients were further assessed for their clinical and molecular parameters during 6th month and 12th month of therapy.

Results:
All 78 new cases showed the presence of a viable load of bacilli at the time of recruitment, but we were able to follow up only on 36 of these patients for one year. Among these, using three different genes, 20/36 for esxA, 22/36 for hsp18 and 24/36 for 16S rRNA cases showed viability of M. leprae at the time of completion of 12 months of multidrug therapy treatment. All these positive patients were histopathologically active and had bacillary indexes ranging between 3+ and 4+. Patients with a high copy number of the Mycobacterium leprae gene, even after completion of treatment as per WHO recommended fixed-dose multidrug therapy, indicated the presence of live bacilli.

Limitations:
Follow up for one year was difficult, especially in Delhi because of the migratory nature of the population. Patients who defaulted for scheduled sampling were not included in the study.

Conclusion:
The presence of a viable load of bacilli even after completion of therapy may be one of the reasons for relapse and continued transmission of leprosy in the community.
Efficacy and tolerance profile of risperidone use in people with autism spectrum disorder in a clinic in Santarém, Pará, Brazil. A retrospective study
Authors: da Silva João Ferreira , Honorato Marcos Manoel , Cremaschi Renata Maria de Carvalho , Coelho Fernando Morgadinho Santos 
Published: March 2023

Objectives:
This study aimed to obtain the profile of efficacy and tolerance of risperidone in the treatment of people with autism spectrum disorder.

Materials and Methods:
This research was a cross-sectional and retrospective study. The medical records of 100 patients diagnosed with ASD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) were analyzed and measures of central tendency and correlation between variables such as gender, age at diagnosis, symptoms, daily dose, comorbidities, polytherapy, adverse drug effects, and outcome (improvement, worsening, and drug discontinuation) were calculated using Pearson’s R test with a level of statistical significance P < 0.05.

Results:
The male gender was the most affected, corresponding to 80% of the participants. The mean age at diagnosis was 6.88 ± 6.24 and the mean dose was 1.89 ± 1.68 mg/day. The use of risperidone for patients with aggressiveness, hyperactivity, insomnia, or self-harm improved in 76% of patients and adverse effects were reported in 27% of cases. The presence of self-harm implied lower chances of improvement (P = 0.05/r = −0.20). Adverse effects were strong predictors of discontinuation (P = 0.01/r = 0.39), and epileptic patients were more likely to have them (P = 0.02/r = 0.20). Male gender was associated with dosages lower than 2 mg/day (P = 0.05/r = 0.23).

Conclusion:
Risperidone is a good option in the management of secondary symptoms of ASD, generally requiring low doses and presenting an acceptable profile of adverse effects. The age of diagnosis does not affect the drug’s efficiency, but it can make the management of ASD difficult.
Impact of COVID-19 on abused pregnant and lactating women receiving reproductive and child health services at tertiary care hospital, New Delhi, India
Authors: Mahapatro Meerambika , Roy Sudeshna , Nayar Poonam , Panchkaran Suruchi , Jadhav Ashwini 
Published: March 2023

Objectives:
The worldwide healthcare system has been overwhelmed by the COVID-19 pandemic’s emergence and increasing intensification. As a result, essential and routine reproductive child health (RCH) services have been severely harmed. The paper tries to find out the impact of COVID-19 on abused pregnant and lactating women receiving routine RCH services at a tertiary care hospital in New Delhi, India.

Material and Methods:
It is an ethnography study undertaken with 150 abused pregnant and lactating women receiving RCH services at Lok Nayak Hospital, New Delhi. They were called and followed up with over the phone from March 23 to May 22, 2020. The findings revealed that there has been an increase in the incidences of domestic violence.

Results:
The main reasons for difficulty reported by the women were inadequate information on changes in antenatal care at the hospital, lockdown restrictions on travel from one facility to another, a breakdown in communication with the healthcare team, and health system barriers. As a result, it exacerbated pregnant and lactating women’s anxiety and distress. During the crisis, these negative consequences on pregnancy outcomes and maternal health must be taken into account immediately.

Conclusion:
Instead of women seeking information and services, the health system can make normal public health services more accessible to women by offering proactive tailored information over the phone on where to go, when to go, what precautions to take, and so on. For better RCH services to women during pandemics, the government must design a health management system that balances routine care with emergency treatment.
PRÁTICAS DE LETRAMENTO ESCOLAR NUMA PERSPECTIVA CRÍTICA NO PROCESSO DE ENSINO E APRENDIZAGEM NA EDUCAÇÃO DE JOVENS E ADULTOS (EJA)
Authors: Sousa Danúbia da Rocha , Oliveira Francisco Humberlan Arruda de 
Published: March 2023

A pesquisa tem como objetivo analisar as práticas de letramento escolar numa perspectiva crítica no processo de ensino e aprendizagem na educação de jovens e adultos (EJA) da escola estadual Padre Pedro da Silva Oliveira, localizada na cidade de Rio Grande do Piauí (PI). A análise leva em consideração o cotidiano da prática de letramento da turma de jovens e adultos da referida escola. Discutir sobre as praticas de leitura e escrita desenvolvida pelos docentes durante as aulas e averiguar se essas práticas colaboram com o desenvolvimento social e crítico dos alunos. Descrever sobre os conhecimentos adquiridos pelos discentes durante o processo de ensino e aprendizagem, refletindo sobre sua inserção no mundo do trabalho, bens culturais e acesso aos recursos tecnológicos. O embasamento teórico utilizado como suporte tem como base os autores Brito (2011), Gadotti (2013), Haddad (2002), entre outros. Foi aplicado um questionário para cada aluno da turma sobre práticas de letramento escolar trabalhadas em sala de aula. A referida pesquisa está em fase de desenvolvimento, mas as informações colhidas por meio de questionário foram possíveis constatar que muitos dos discentes não têm domínio das diversas formas de letramentos, como interpretação de textos, leituras de jornais, revistas, charges, enfim, eles conseguem ler e escrever sem dificuldades, porém alguns ainda não conseguem interpretar as diferentes formas de leituras (formais e não formais).

Palavras-chave: Cultura letrada; letramento e educação de jovens e adultos.
Evaluation of the High-Throughput Screening System for Assessing the Behavioral Response of FemaleAedes aegyptito Natural Products
Authors: Magalhães Natália M. G. , Achee Nicole L. , Grieco John P. , Espindola Laila S. 
Published: March 2023

ABSTRACTAs part of an arbovirus vector control strategy, chemical control continues to be a mainstay in mitigating the burden of disease. The current arsenal of chemicals used for this purpose, however, are becoming challenged rapidly because of issues of insecticide resistance and environmental pressure. Newer, environmentally friendly actives are of interest to supplement aging chemistries; therefore efforts to screen compounds for insecticidal activity are warranted. This study evaluated the efficacy of the high-throughput screening system (HITSS) for measuring the behavior-modifying actions of Brazilian Cerrado plant extracts, oils, and other compounds against Aedes aegypti. Different concentrations were evaluated, with 8 of 34 samples tested demonstrating either contact irritancy, spatial repellency, or attractiveness. We concluded several natural products screened in this study showed promise for use against mosquito vectors like Ae. aegypti, and that the compact modular HITSS assay constitutes a robust tool for measuring the behavioral responses of mosquitoes in the search for novel insecticides derived from natural products.
Aedes japonicus japonicusin Nebraska and Texas
Authors: Sames William J. , Hamik Jeff , Mann James G. , Bast Joshua D. , Pitts R. Jason 
Published: March 2023

ABSTRACTAedes japonicus japonicus continues to spread westward and in this study, its presence is documented in 8 counties in Nebraska and in Bowie County, TX. In 1998, Ae. japonicus was collected in Connecticut, New Jersey, and New York for the 1st records of this species in North America. Except for Louisiana, it has been reported from all states that border or are east of the Mississippi River. In Canada, it has been reported in Ontario and all eastern provinces. In the Pacific Northwest, it has been reported in Washington, Oregon, and British Columbia, and in the midwestern states that do not border the Mississippi River, Kansas, Oklahoma, and South Dakota are the only states to have reported its presence in peer-reviewed journals.
Status of Vector Control Capabilities and Capacities in Florida and Texas, and its Potential Public Health Consequences
Authors: Peper Steven T. , Xue Rui-De , Presley Steven M. 
Published: March 2023

ABSTRACTIt has been reported that roughly 80% of vector control organizations throughout the southern USA lack critical capabilities to properly address potential vector populations and vector-borne diseases within their jurisdictions. This study further investigated current vector control capabilities and capacity within the states of Florida and Texas. It was reported that only 26% of jurisdictions in Florida and 14% in Texas reported that they were “fully capable.” Both states are among the top 4 states relative to the number of human cases of mosquito-borne diseases, and both states have had local transmission of Zika virus. Respondents from Florida indicated that 88% of jurisdictions have vector control capabilities to some degree, with 65% of those reporting they had sufficient capabilities. Respondents from Texas indicated that 89% of jurisdictions have vector control capabilities to some degree, with 67% of those reporting they had sufficient capabilities. As the prioritization of resource commitment for vector control capabilities varies throughout the USA, it is imperative that each state evaluates their specific needs and current capabilities and capacity to best ensure the public health needs of their constituents.
Habitat-Specific Host Selection Patterns ofCulex quinquefasciatusandCulex nigripalpusin Florida
Authors: Hancock Chip , Camp Jeremy V. 
Published: March 2023

ABSTRACTBlood-engorged Culex quinquefasciatus and Cx. nigripalpus were collected from 140 locations throughout Sarasota County, FL, from 2017 to 2020 to determine local, habitat-specific, and seasonal variations in the host usage patterns of these 2 important arbovirus vectors. Mosquitoes were collected using light traps, gravid traps, and via aspiration of resting shelters. Host was determined from 920 samples using multiple polymerase chain reaction protocols that target mitochondrial sequences specific to mammals, birds, and reptiles. The data were analyzed to test for statistical associations between host class and season or with habitat categories (urban, suburban, and rural). Culex quinquefasciatus took significantly more blood meals from birds compared to mammals, though a seasonal shift to a higher ratio of mammalian host usage was observed in fall. There was a habitat-dependent pattern of host usage by Cx. nigripalpus, with significantly more mammalian hosts identified from mosquitoes captured in rural habitats and a similar ratio of mammalian and avian hosts in urban habitats. In general humans were used as hosts by Cx. nigripalpus less often compared to Cx. quinquefasciatus. In contrast to previous studies, Cx. nigripalpus utilized ectothermic hosts (mostly reptiles) at a much higher ratio and exhibited no apparent seasonal shift in host selection.
Deterrent Effects of Glyphosate on Oviposition and Larval Development ofCulex quinquefasciatus
Authors: Nikbakhtzadeh Mahmood R. , Fuentes Yelissa 
Published: March 2023

ABSTRACTGlyphosate is one of the most common herbicides used to control weeds in the USA. This herbicide can impact the mosquito life cycle through being carried to mosquito habitats by runoff. This study investigates the effects of glyphosate on the larval development and oviposition of a laboratory colony of Culex quinquefasciatus. Our experiments indicated that a concentration of 1 g/liter glyphosate was lethal to larval instars or the larvae impacted were either unable to molt to pupae or never emerged as adults. Larval instars exposed to 0.5 g/liter glyphosate experienced a similar impact; however, the larval stage was extended and pupation was considerably delayed. Mosquitoes oviposited in 0.5 g/liter glyphosate laid the same number of egg rafts as in water, but a considerably lower number of eggs exposed to glyphosate hatched as first instars. If gravid females laid their eggs in 1 g/liter glyphosate versus water, the difference between the 2 groups would be statistically significant and a very low number of eggs exposed to glyphosate could ever hatch into larvae. In an oviposition assay carried out in a cage with 3 choices of water, 0.5 g/liter, and 1 g/liter glyphosate, a higher number of egg rafts were laid in water, followed by 0.5 g/liter and 1 g/liter glyphosate concentrations, respectively. Our study indicated such a severe effect of glyphosate on all immature stages of Cx. quinquefasciatus that no adult could ever emerge.