bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remission of chronic blastocystosis using ciprofloxacin
Authors: Rojas‐Jaimes Jesús , Vesco‐Monteagudo Eduardo 
Published: June 2023

AbstractBlastocystis hominis is a controversial parasite because of its taxonomy and its treatment. In this report, an immunocompetent person with chronic blastocystosis, in whom a series of treatments were used without success, except for the use of ciprofloxaci. Ciprofloxacin could be an antibiotic of choice in chronic blastocystosis.
Cytomegalovirus‐induced oral ulcers: A case report and literature review
Authors: Pinana Margaux , Rapoport Camille , Champtiaux Nicolas , Lescaille Géraldine , Allenbach Yves , Rochefort Juliette 
Published: June 2023

Key Clinical MessageCytomegalovirus (CMV) ulcerations are rare clinical entities, but their occurrence is favored in immunocompromised patients who present a favorable environment for opportunistic infections. We describe the case of a patient treated for a systemic lupus erythematosus suffering from deep oral ulcerations. The case illustrates the complexity of establishing a precise etiological diagnosis of CMV lesions, as the diagnostic hypothesis can be varied: related to an immunodeficiency disorder or drug‐induced toxidermia.
Long‐standing laryngeal rhinoscleroma with rare Mikulicz cells
Authors: Peerani Raheem , Shah Manish , Minnema Brian , Ghaffar Hasan , Chetty Runjan , Delabie Jan , Perez‐Ordonez Bayardo , Xia Daniel 
Published: June 2023

Key Clinical MessageRhinoscleroma is an infectious granulomatous disease. It is important to identify pathognomonic Mikulicz cells on microscopy, as these can be rare and the chronic inflammatory infiltrate can appear otherwise nonspecific on biopsies.
Mass Transfer Behavior of a Rotating Packed Bed of Raschig Rings Suitable for Wastewater Treatment
Authors: Soliman Mohamed S. , Nosier Shaaban A. , Hussein Mohamed , Abdel-Aziz Mohamed H. , Sedahmed Gomaa H. , El-Naggar Mohamed A. 
Published: June 2023

AbstractThe mass transfer behavior of a rotating packed bed of Raschig rings was examined to increase the rate of liquid‐solid diffusion‐controlled reactions common in the production of fine chemicals, pharmaceuticals, and wastewater treatment. The aim was to measure the enhancing effect of the centrifugal force and the high area per unit volume of the bed, using diffusion‐controlled copper dissolution in acidified dichromate as the experimental approach and the bed rotation speed, the Raschig ring diameter, and the bed height as variables. A dimensionless mass transfer equation suited for scaling up and reactor design was used to correlate the data. Measurement of the specific mechanical power consumption ε of the rotating bed under different conditions revealed that the energy utilization efficiency increases with decreasing bed rotation speed.
Assignment of the absolute configuration of molecules that are chiral by virtue of deuterium substitution using chiral tag molecular rotational resonance spectroscopy
Authors: Vang Zoua Pa , Sonstrom Reilly E. , Scolati Haley N. , Clark Joseph R. , Pate Brooks H. 
Published: June 2023

AbstractChiral tag molecular rotational resonance (MRR) spectroscopy is used to assign the absolute configuration of molecules that are chiral by virtue of deuterium substitution. Interest in the improved performance of deuterated active pharmaceutical ingredients has led to the development of precision deuteration reactions. These reactions often generate enantioisotopomer reaction products that pose challenges for chiral analysis. Chiral tag rotational spectroscopy uses noncovalent derivatization of the enantioisotopomer to create the diastereomers of the 1:1 molecular complexes of the analyte and a small, chiral molecule. Assignment of the absolute configuration requires high‐confidence determinations of the structures of these weakly bound complexes. A general search method, CREST, is used to identify candidate geometries. Subsequent geometry optimization using dispersion corrected density functional theory gives equilibrium geometries with sufficient accuracy to identify the isomers of the chiral tag complexes produced in the pulsed jet expansion used to introduce the sample into the MRR spectrometer. Rotational constant scaling based on the fact that the diastereomers have the same equilibrium geometry gives accurate predictions allowing identification of the homochiral and heterochiral tag complexes and, therefore, assignment of absolute configuration. The method is successfully applied to three oxygenated substrates from enantioselective Cu‐catalyzed alkene transfer hydrodeuteration reaction chemistry.
The firm is dead; long live the firm: Classifying firm survival after mergers and acquisitions
Authors: Madden Timothy M. , Madden Laura T. , Smith Anne D. , Strickling Jason A. 
Published: June 2023

AbstractIdentifying the surviving firms following mergers and acquisitions (M&A) presents challenges in organizational research. The paper offers a solution to this issue by examining prior research on M&A and firm survival to identify three empirically‐relevant criteria—strategic intent, corporate name retention, and top management team composition—and integrate them into a process‐driven typology of firm survival following M&A. To demonstrate the utility of this method, we apply this typology to an industry rich with M&A activity: the United States telecommunications industry.
Water hyacinth as a green and sustainable material for carbon aerogel electrodes utilized in membrane capacitive deionization
Authors: Nguyen Ngan Tuan , Duong Thu Thuy T. , Phan Thuy Van T. , Truong Cong Chien , Nguyen Van Vien , Tran Thanh Nhut , Nguyen Thanh Tung , Anh Tuan Huynh , Hoang Sy Minh Tuan , Ngo Hoang Long , Chung Nguyen Thi Kim 
Published: June 2023

AbstractWater hyacinth is a substantial and quick‐growing plant that can strongly invade and negatively affect the aquatic ecosystem, causing many problems to the water environment by consuming nutrients and oxygen from surface water. However, the hierarchical porous carbon derived from water hyacinth can be employed for the removal of oil spills, heavy metals, or wastewater nutrients. Recently, water‐hyacinth‐derived carbon aerogel has been utilized as electrode for the desalination of brackish water using membrane capacitive deionization (MCDI) technology. In this research, lignocellulose aerogels were synthesized from water hyacinth, which were then pyrolyzed to obtain carbon aerogel and then treated with KOH to acquire activated carbon aerogel, with the corresponding surface area of 51 and 100 m2 g−1. The desalination capacity of the MCDI device was also evaluated using a 200 ppm NaCl feed water solution with an applied potential of 1.2 V. A high salt adsorption capacity value of 14.69 mg g−1 was achieved after 3000 s. These results will lead a new research area of biomass and bio‐waste conversion to fabricate CDI‐utilized carbon aerogel electrodes.
Groundwater constituents and the incidence of kidney cancer
Authors: Soerensen Simon John Christoph , Montez‐Rath Maria E. , Cheng Iona , Gomez Scarlett Lin , Oh Debora L. , Jackson Christian , Li Jinhui , Rehkopf David , Chertow Glenn M. , Langston Marvin E. , Ganesan Calyani , Pao Alan C. , Chung Benjamin I. , Leppert John T. 
Published: June 2023

AbstractBackgroundKidney cancer incidence demonstrates significant geographic variation suggesting a role for environmental risk factors. This study sought to evaluate associations between groundwater exposures and kidney cancer incidence.MethodsThe authors identified constituents from 18,506 public groundwater wells in all 58 California counties measured in 1996–2010, and obtained county‐level kidney cancer incidence data from the California Cancer Registry for 2003–2017. The authors developed a water‐wide association study (WWAS) platform using XWAS methodology. Three cohorts were created with 5 years of groundwater measurements and 5‐year kidney cancer incidence data. The authors fit Poisson regression models in each cohort to estimate the association between county‐level average constituent concentrations and kidney cancer, adjusting for known risk factors: sex, obesity, smoking prevalence, and socioeconomic status at the county level.ResultsThirteen groundwater constituents met stringent WWAS criteria (a false discovery rate <0.10 in the first cohort, followed by p values <.05 in subsequent cohorts) and were associated with kidney cancer incidence. The seven constituents directly related to kidney cancer incidence (and corresponding standardized incidence ratios) were chlordane (1.06; 95% confidence interval [CI], 1.02–1.10), dieldrin (1.04; 95% CI, 1.01–1.07), 1,2‐dichloropropane (1.04; 95% CI, 1.02–1.05), 2,4,5‐TP (1.03; 95% CI, 1.01–1.05), glyphosate (1.02; 95% CI, 1.01–1.04), endothall (1.02; 95% CI, 1.01–1.03), and carbaryl (1.02; 95% CI, 1.01–1.03). Among the six constituents inversely related to kidney cancer incidence, the standardized incidence ratio furthest from the null was for bromide (0.97; 95% CI, 0.94–0.99).ConclusionsThis study identified several groundwater constituents associated with kidney cancer. Public health efforts to reduce the burden of kidney cancer should consider groundwater constituents as environmental exposures that may be associated with the incidence of kidney cancer.
Flexible system software scheduling for asymmetric multicore systems with PMCSched: A case for Intel Alder Lake
Authors: Bilbao Carlos , Saez Juan Carlos , Prieto‐Matias Manuel 
Published: June 2023

SummaryAsymmetric multicore processors (AMPs) couple high‐performance big cores and power‐efficient small ones, all exposing a shared instruction set architecture to software, but with different microarchitectural features. The energy efficiency benefits of AMPs, together with the general‐purpose nature of the various cores, have led hardware manufacturers to build commercial AMP‐based products, first for the mobile and embedded domains, and more recently, for the desktop market segment, as with the Intel Alder Lake processor family. This trend indicates that AMPs may become a solid and more energy efficient replacement for symmetric multicores in a wide range of application domains. Previous research has demonstrated that the system software can substantially improve scheduling—critical to get the most out of heterogeneous cores—by leveraging hardware facilities that are directly managed by the OS, such as performance monitoring counters, or the recently introduced Intel Thread Director technology. Unfortunately, the OS‐level support enabling access to these hardware facilities may often take a long time to be adopted in operating systems, or may come in forms that make its utilization challenging from specific levels of the system software stack, especially in production systems. To fill this gap, we propose PMCSched, an open‐source framework enabling rapid development and evaluation of custom scheduling‐related support in the Linux kernel. PMCSched greatly simplifies the design and implementation of a wide range of scheduling policies for multicore systems that operate at different system software layers without requiring to patch the kernel. To demonstrate the potential of our framework, we conduct a set of experimental case studies on asymmetry‐aware scheduling for Intel Alder Lake processors.
Quantum Dot‐Vitrimer Composites: An Approach for Reprocessable, Self‐Healable, and Sustainable Luminescent Materials
Authors: Zhang Yong‐Yun , Liu Kuan‐Ting , Fang Mu‐Huai , Leung Man‐kit 
Published: June 2023

AbstractQuantum dots (QDs) are of great concern in many fields. However, they suffer from high toxicity and may lead to environmental pollution. We report the development of a QD‐vitrimer composite with reprocessable, self‐healable, and sustainable properties. Our QD‐vitrimer composite reveals fine transparency and highly uniform QDs distribution without significant aggregation. The photoluminescence quantum yield (PLQY) is basically about four times higher than the commercial QD films. The QD‐vitrimer composites can be recycled at least three times without any significant loss in structure and luminescence efficiency. A prototype light‐emitting diode device is fabricated to demonstrate the promising potential of QD‐vitrimer composites in real application. This research sheds light on developing environmentally friendly luminescent materials and opens up an avenue for designing advanced nanomaterials‐vitrimer composites.
Single‐cell RNA sequencing reveals a mechanism underlying the susceptibility of the left atrial appendage to intracardiac thrombogenesis during atrial fibrillation
Authors: Yang Jie , Tan Hu , Sun Mengjia , Chen Renzheng , Jian Zhao , Song Yuanbin , Zhang Jihang , Bian Shizhu , Zhang Bo , Zhang Yi , Gao Xubin , Chen Zhen , Wu Boji , Ye Xiaowei , Lv Hailin , Liu Zhen , Huang Lan 
Published: June 2023

AbstractBackgroundAtrial fibrillation (AF) is associated with an increased risk of thrombosis of the left atrial appendage (LAA). However, the molecular mechanisms underlying this site‐specificity remain poorly understood. Here, we present a comparative single‐cell transcriptional profile of paired atrial appendages from patients with AF and illustrate the chamber‐specific properties of the main cell types.MethodsSingle‐cell RNA sequencing analysis of matched atrial appendage samples from three patients with persistent AF was evaluated by 10× genomics. The AF mice model was created usingTbx5knockout mice. Validation experiments were performed by glutathione S‐transferase pull‐down assays, coimmunoprecipitation (Co‐IP), cleavage assays and shear stress experiments in vitro.ResultsIn LAA, phenotype switching from endothelial cells to fibroblasts and inflammation associated with proinflammatory macrophage infiltration were observed. Importantly, the coagulation cascade is highly enriched in LAA endocardial endothelial cells (EECs), accompanying the up‐regulation of a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) and the down‐regulation of the tissue factor pathway inhibitor (TFPI) and TFPI2. Similar alterations were verified in an AF mouse model (Tbx5+/−) and EECs treated with simulated AF shear stress in vitro. Furthermore, we revealed that the cleavage of both TFPI and TFPI2 based on their interaction with ADAMTS1 would lead to loss of anticoagulant activities of EECs.ConclusionsThis study highlights the decrease in the anticoagulant status of EECs in LAA as a potential mechanism underlying the propensity for thrombosis, which may aid the development of anticoagulation therapeutic approaches targeting functionally distinct cell subsets or molecules during AF.
Local adaptation and host specificity to copepod intermediate hosts by the tapeworm Schistocephalus solidus
Authors: Shim Kum C. , Peterson Christopher R. , Bolnick Daniel I. 
Published: June 2023

AbstractHost–parasite coevolution may lead to patterns of local adaptation in either the host or parasite. For parasites with complex multi‐host life cycles, this coevolution may be more challenging as they must adapt to multiple geographically varying hosts. The tapeworm Schistocephalus solidus exhibits some local adaptation to its second intermediate host, threespine stickleback, to which the parasite is strictly specialized. However, the tapeworm's adaptation to its first intermediate host (any of a number of copepod species) is not documented. We investigated if there was local adaptation and host specify in the tapeworm Schistocephalus solidus to its copepod first intermediate hosts. We exposed copepods from five lakes in Vancouver Island (BC, Canada) to local (i.e. same lake) and foreign tapeworms in a reciprocal exposure experiment. Results indicate that the tapeworm is not locally adapted to the copepods. Instead, we observed moderate‐effect host specificity, infection rates being higher in certain copepod species than in others. Infection rates also varied among cestode populations. These results show that although S. solidus infects multiple copepod genera, they are not equally competent hosts. Differences in S. solidus epidemiology among lakes is likely to be driven more by this partial specialization, than by local adaptation to first intermediate hosts.
Host age affects the performance of the root hemiparasitic plant Rhinanthus alectorolophus
Authors: Moncalvillo Belén , Matthies Diethart 
Published: June 2023

AbstractInteractions between root hemiparasitic plants and their hosts are strongly affected by host identity, but may also depend on the condition of the host. An important determinant of host quality could be host age, as it may influence host size, allocation patterns, responses to infection, and the strength of competition for light between parasite and host. We investigated the effects of host species identity, host age and above‐ground separation of hemiparasite and host on the interactions between the hemiparasite Rhinanthus alectorolophus and five host species in a factorial experiment. The host species were planted at six different times, from 10 weeks before the parasite was planted to 4 weeks after. Host age strongly influenced the performance of the parasite, but these effects also varied among host species. Parasites grew largest with hosts planted at the same time or 2 weeks earlier, but their performance strongly declined both with increasing host age and with the time they grew autotrophically. A large part of the variation due to host age but not of that due to host species identity could be related to the negative influence of host size at the likely time of parasite attachment. The low quality of older hosts was not due to light competition, suggesting that effective exploitation of these hosts was prevented by other factors like harder roots, stronger defense against parasite attack or competition for resources taken up by the host roots. Suppression of host growth by the parasites declined with increasing host age. The results indicate that the choice of host age may influence the results of studies on hemiparasites. They also highlight the importance for annual root hemiparasites of attachment in early spring, that is, at a time when their mostly perennial hosts produce fresh roots but are still poorly developed above ground.
Seasonal and perennial water populations of an endemic crayfish differ in behavioural responses to drying but not metabolism
Authors: Emery‐Butcher Holly E. , Beatty Stephen J. , Robson Belinda J. 
Published: June 2023

AbstractCrayfish perform important roles within freshwater ecosystems, including in regions where global warming is causing prolonged drying of waterbodies. However, little is known about responses of crayfish to habitat drying from both a behavioural and physiological perspective. We compared burrowing ability, survival and metabolism of the crayfish Cherax quinquecarinatus from a seasonal stream and a perennial stream. Burrowing ability and crayfish survival were quantified in a mesocosm experiment contrasting sediment type (sand vs. clay/sand mixture) and water regime. Aerobic scope, standard metabolic rate (SMR) and maximum metabolic rate (MMR) were also compared using intermittent flow respirometry. Crayfish from the seasonal stream showed limited burrowing ability but higher survival in the drying treatment, while the perennial stream crayfish burrowed strongly in the clay/sand sediment. Higher survival suggests that crayfish from seasonal streams might be physiologically better adapted to drying. Larger crayfish burrowed more proficiently, reaching the saturated hyporheic zone refuge in the clay/sand sediment treatment. SMR/MMR/aerobic scope did not differ between populations or respirometry runs; however, SMR differed between individuals, perhaps due to personality traits. There was a significant negative relationship between MMR/aerobic scope and weight. Sediment type may limit C. quinquecarinatus burrowing and persistence through drying. Crayfish populations did not differ in terms of metabolism; however, crayfish from seasonal habitats may possess more efficient physiological adaptations to drying. This study highlights the need for greater research attention on the effects of climatic drying on both the behaviour and the physiology of species exposed to climate change.
Advances in separation and identification of biologically important milk proteins and peptides
Authors: Stastna Miroslava 
Published: June 2023

AbstractMilk is a rich source of biologically important proteins and peptides. In addition, milk contains a variety of extracellular vesicles (EVs), including exosomes, that carry their own proteome cargo. EVs are essential for cell–cell communication and modulation of biological processes. They act as nature carriers of bioactive proteins/peptides in targeted delivery during various physiological and pathological conditions. Identification of the proteins and protein‐derived peptides in milk and EVs and recognition of their biological activities and functions had a tremendous impact on food industry, medicine research, and clinical applications. Advanced separation methods, mass spectrometry (MS)‐based proteomic approaches and innovative biostatistical procedures allowed for characterization of milk protein isoforms, genetic/splice variants, posttranslational modifications and their key roles, and contributed to novel discoveries. This review article discusses recently published developments in separation and identification of bioactive proteins/peptides from milk and milk EVs, including MS‐based proteomic approaches.
Biogas production potential from animal farm waste in Bangladesh: Case studies of two selected farms
Authors: Das Priyom , Islam Kazi Sifatul , Uddin S. M. Mijan 
Published: June 2023

AbstractIncreasing prices of conventional energy sources and ongoing environmental pollution have encouraged policymakers to search for sustainable energy resources. In developing countries, livestock waste is often mismanaged and negatively impacts the environment. Bioenergy production from agricultural and animal wastes can be a viable solution. This study conducted a month‐wise survey on a multipurpose farm and a dairy farm in Chattogram, Bangladesh, to estimate the bioenergy potential from farm livestock waste. Based on the survey, mathematical modeling was applied to estimate the selected farm's theoretical bioelectricity, biogas and biofertilizer production potential. The analysis shows that the multipurpose and dairy farm have an annual biogas production potential of 209,660.2 and 1,205,035.5 m3, generating 3.77E+05 and 2.17E+06 kWhyr−1 of bioelectricity, respectively. The multipurpose farm and the dairy farm could generate 982.03 and 16092.49 tons of bio manure yearly and had an annual biofertilizer potential of 64.36 and 2090.91 tons. Both environmental and economic analyses show that both farms have good greenhouse gas mitigation potential and can earn significant revenue by selling electricity and biofertilizer in the market. The outcome can provide valuable guidelines for policymakers to invest in bioenergy production from farm animal waste.