bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extending and refining the fearful ape hypothesis
Authors: Grossmann Tobias 
Published: May 2023

Abstract
The fearful ape hypothesis (FAH) presents an evolutionary-developmental framework stipulating that in the context of cooperative caregiving, unique to human great ape group life, heightened fearfulness was adaptive. This is because from early in human ontogeny fearfulness expressed and perceived enhanced care-based responding and cooperation with mothers and others. This response extends and refines the FAH by incorporating the commentaries' suggestions and additional lines of empirical work, providing a more comprehensive and nuanced version of the FAH. Specifically, it encourages and hopes to inspire cross-species and cross-cultural, longitudinal work elucidating evolutionary and developmental functions of fear in context. Beyond fear, it can be seen as a call for an evolutionary-developmental approach to affective science.
Population trends, size, and potential threats to Bristle-thighed Curlew Numenius tahitiensis: new data from French Polynesia
Authors: Jiguet Frédéric 
Published: May 2023

Summary
Based on censuses in 2021 and 2022 of Bristle-thighed Curlews Numenius tahitiensis on 10 atolls of French Polynesia, the species has declined by c.50% over the last two decades. While the species has recently been down-listed from “Vulnerable” to “Near Threatened”, these new data would qualify it for an “Endangered” Red List status. The non-breeding population on Tuamotu numbers approximately 1,000 curlews and up to 1,500 individuals in all of Eastern Polynesia. On uninhabited islands, the expansion of copra (coconut pulp) exploitation has caused long-term disturbance for curlews, increased predation by pet dogs, and introduced or reinforced non-native rat populations. Climate change, particularly sea-level rise, will add to changes in land use that shrink the suitable habitat for Bristle-thighed Curlews in French Polynesia. As this study shows, obtaining population trends for species breeding in remote areas may best be achieved through surveys at key non-breeding sites.
SMITH AT 300: UNIVERSAL HUMAN NATURE, THE DIVISION OF LABOR, AND AFRICAN DEVELOPMENT
Authors: Lange Jérôme 
Published: May 2023

“Since such, therefore, are the advantages of water-carriage, it is natural that the first improvements of art and industry should be made where this conveniency opens the whole world for a market to the produce of every sort of labour, and that they should always be much later in extending themselves into the inland parts of the country. … All the inland parts of Africa, and all that part of Asia which lies any considerable way north of the Euxine and Caspian seas, the antient Scythia, the modern Tartary and Siberia, seem in all ages of the world to have been in the same barbarous and uncivilized state in which we find them at present. … There are in Africa none of those great inlets, such as the Baltic and Adriatic seas in Europe, the Mediterranean and Euxine seas in both Europe and Asia, and the gulphs of Arabia, Persia, India, Bengal, and Siam, in Asia, to carry maritime commerce into the interior parts of that great continent: and the great rivers of Africa are at too great a distance from one another to give occasion to any considerable inland navigation.”WNI.iii.4–8
An Interdisciplinary Water Risk Assessment Framework for Sustainable Water Management in Ontario, Canada
Authors: Sandhu Guneet , Weber Olaf , Wood Michael O. , Rus Horatiu A. , Thistlethwaite Jason 
Published: May 2023

AbstractThe Province of Ontario in Canada illustrates contemporary water security issues, where despite perception of water abundance, water challenges arise locally. Water risks stem from biophysical dimensions of groundwater depletion, low surface water flows, and degraded quality, and, contextual dimensions of regulatory uncertainty, public concerns and perception. While academic, policy, and practitioner interest is growing, literature reveals major gaps in comprehensive assessment of multidimensional water risks at the subwatershed scale. Addressing these gaps, the study developed a locally attuned and interdisciplinary water risk assessment framework. Using secondary mixed data analysis, the study integrated quantitative and qualitative data for water quantity and quality risks, regulatory trends, water user conflicts for 38 subwatersheds in Ontario. The framework identifies subwatersheds and sectors at high, moderate, and low risk along with media and public concern themes. The study finds high and moderate risk potential in at least 50% of studied subwatersheds for all water risk indicators and challenges the myth of water abundance in Great Lakes watershed of Ontario. The study advances knowledge in water risk assessment by applying social‐ecological perspectives, interdisciplinary approaches of Risk Theory, and mixed methods to provide a comprehensive evaluation of water security and demonstrates integration of social science perspectives in the field of sociohydrology. Our framework assesses interdisciplinary water risks to inform multisector sustainable water management decisions. While spatially scoped to populous subwatersheds of Ontario, this framework can be methodologically generalized to other geographical regions by using local data.
Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix
Authors: Duan Yi , Zhang Xiaozhen , Ying Honggang , Xu Jian , Yang Hanshen , Sun Kang , He Lihong , Li Muchun , Ji Yongtao , Liang Tingbo , Bai Xueli 
Published: May 2023

AbstractHighly desmoplastic and immunosuppressive tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) contributes to tumor progression and resistance to current therapies. Clues targeting the notorious stromal environment have offered hope for improving therapeutic response whereas the underlying mechanism remains unclear. Here, we find that prognostic microfibril associated protein 5 (MFAP5) is involved in activation of cancer-associated fibroblasts (CAFs). Inhibition of MFAP5highCAFs shows synergistic effect with gemcitabine-based chemotherapy and PD-L1-based immunotherapy. Mechanistically, MFAP5 deficiency in CAFs downregulates HAS2 and CXCL10 via MFAP5/RCN2/ERK/STAT1 axis, leading to angiogenesis, hyaluronic acid (HA) and collagens deposition reduction, cytotoxic T cells infiltration, and tumor cells apoptosis. Additionally, in vivo blockade of CXCL10 with AMG487 could partially reverse the pro-tumor effect from MFAP5 overexpression in CAFs and synergize with anti-PD-L1 antibody to enhance the immunotherapeutic effect. Therefore, targeting MFAP5highCAFs might be a potential adjuvant therapy to enhance the immunochemotherapy effect in PDAC via remodeling the desmoplastic and immunosuppressive microenvironment.
Should a matched sibling donor still be considered the primary option for allogeneic hematopoietic cell transplantation in patients over 50 years of age with myelodysplastic syndrome?
Authors: Konuma Takaaki , Itonaga Hidehiro , Ishiyama Ken , Doki Noriko , Uchida Naoyuki , Sawa Masashi , Katayama Yuta , Tanaka Masatsugu , Ueda Yasunori , Onizuka Makoto , Miyakoshi Shigesaburo , Ozawa Yukiyasu , Fukuda Takahiro , Matsuoka Ken-ichi , Tanaka Junji , Kimura Takafumi , Ichinohe Tatsuo , Atsuta Yoshiko 
Published: May 2023

AbstractHuman leukocyte antigen (HLA)-matched sibling donors (MSDs) are the preferred choice for allogeneic hematopoietic cell transplantation (HCT). However, as myelodysplastic syndrome (MDS) is most frequently diagnosed in the elderly, MSDs are also likely to be of advanced age. It is unclear whether an MSD should be considered the primary choice for allogeneic HCT in elderly patients with MDS. We retrospectively compared survival and other outcomes in 1787 patients with MDS over 50 years of age and receiving allogeneic HCT between 2014 and 2020, using either MSD (n = 214), 8/8 allele-matched unrelated donor (MUD) (n = 562), 7/8 allele-MUD (n = 334), or unrelated cord blood (UCB) (n = 677) in Japan. In multivariate analysis, compared to MSD transplants, the risk of relapse was significantly lower following 8/8MUD transplants (hazard ratio [HR], 0.74; P = 0.047), whereas non-relapse mortality was significantly higher following UCB transplants (HR, 1.43; P = 0.041). However, donor type did not determine overall survival, disease-free survival, or graft-versus-host disease (GVHD)-free, relapse-free survival, but chronic GVHD-free, relapse-free survival was better after UCB (HR, 0.80; P = 0.025) and 8/8MUD (HR, 0.81; P = 0.032) compared to MSD transplants. Our study demonstrated that MSDs are not superior to alternative HCT methods, such as 8/8MUD, 7/8MUD, or UCB, in this population.
Anti-vascular endothelial growth factor dosing frequency and visual outcomes in macular oedema following branch retinal vein occlusion
Authors: Modi Yasha S. , Goduni Lediana , Moini Hadi , Gibson Andrea , Boucher Nick , Lucas Genevieve , Dhoot Dilsher S. 
Published: May 2023

Abstract
Objectives
To determine the relationship between treatment frequency with intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents and visual acuity (VA) outcomes in eyes with macular oedema (MO) secondary to branch retinal vein occlusion (BRVO) in US clinical practice.

Methods
Study eyes that initiated anti-VEGF injections between January 2012 and May 2016 were followed for ≥1 year in a retrospective analysis of medical records (Vestrum Health database). Eyes were analysed in 2 cohorts by treatment duration (years 1 and 2) and then in 2 subcohorts by injection frequency (≤6 or ≥7 injections/year).

Results
Among 3099 eyes with MO secondary to BRVO, 1197 (38.6%) received ≤6 injections (mean injections, 4.6; baseline mean VA, 53 letters) and 1902 (61.4%) received ≥7 injections through 1 year (mean injections, 8.8; baseline mean VA, 52 letters). At year 1, mean VA gain from baseline was 10.4 versus 13.9 letters in eyes receiving ≤6 versus ≥7 injections (p < 0.001). At year 2, mean VA in eyes receiving ≤6 (n = 42) versus ≥7 injections (n = 227) was 64 versus 68 letters, respectively (p = 0.19). Mean VA change between the start and end of year 2 in eyes receiving ≥7 injections in year 1 and ≤6 in year 2 differed significantly from that of eyes receiving ≥7 injections in both years (–3.0 vs 0.7 letters, respectively; p < 0.001).

Conclusions
In routine clinical practice, more frequent dosing with anti-VEGF agents was associated with greater visual benefits in eyes with MO secondary to BRVO.
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus
Authors: Navickas Albertas , Asgharian Hosseinali , Winkler Juliane , Fish Lisa , Garcia Kristle , Markett Daniel , Dodel Martin , Culbertson Bruce , Miglani Sohit , Joshi Tanvi , Yin Keyi , Nguyen Phi , Zhang Steven , Stevers Nicholas , Hwang Hun-Way , Mardakheh Faraz , Goga Andrei , Goodarzi Hani 
Published: May 2023

AbstractCancer cells often co-opt post-transcriptional regulatory mechanisms to achieve pathologic expression of gene networks that drive metastasis. Translational control is a major regulatory hub in oncogenesis; however, its effects on cancer progression remain poorly understood. Here, to address this, we used ribosome profiling to compare genome-wide translation efficiencies of poorly and highly metastatic breast cancer cells and patient-derived xenografts. We developed dedicated regression-based methods to analyse ribosome profiling and alternative polyadenylation data, and identified heterogeneous nuclear ribonucleoprotein C (HNRNPC) as a translational controller of a specific mRNA regulon. We found that HNRNPC is downregulated in highly metastatic cells, which causes HNRNPC-bound mRNAs to undergo 3′ untranslated region lengthening and, subsequently, translational repression. We showed that modulating HNRNPC expression impacts the metastatic capacity of breast cancer cells in xenograft mouse models. In addition, the reduced expression of HNRNPC and its regulon is associated with the worse prognosis in breast cancer patient cohorts.
Multimodal spatiotemporal phenotyping of human retinal organoid development
Authors: Wahle Philipp , Brancati Giovanna , Harmel Christoph , He Zhisong , Gut Gabriele , del Castillo Jacobo Sarabia , Xavier da Silveira dos Santos Aline , Yu Qianhui , Noser Pascal , Fleck Jonas Simon , Gjeta Bruno , Pavlinić Dinko , Picelli Simone , Hess Max , Schmidt Gregor W. , Lummen Tom T. A. , Hou Yanyan , Galliker Patricia , Goldblum David , Balogh Marton , Cowan Cameron S. , Scholl Hendrik P. N. , Roska Botond , Renner Magdalena , Pelkmans Lucas , Treutlein Barbara , Camp J. Gray 
Published: May 2023

AbstractOrganoids generated from human pluripotent stem cells provide experimental systems to study development and disease, but quantitative measurements across different spatial scales and molecular modalities are lacking. In this study, we generated multiplexed protein maps over a retinal organoid time course and primary adult human retinal tissue. We developed a toolkit to visualize progenitor and neuron location, the spatial arrangements of extracellular and subcellular components and global patterning in each organoid and primary tissue. In addition, we generated a single-cell transcriptome and chromatin accessibility timecourse dataset and inferred a gene regulatory network underlying organoid development. We integrated genomic data with spatially segmented nuclei into a multimodal atlas to explore organoid patterning and retinal ganglion cell (RGC) spatial neighborhoods, highlighting pathways involved in RGC cell death and showing that mosaic genetic perturbations in retinal organoids provide insight into cell fate regulation.
High-contrast en bloc staining of mouse whole-brain and human brain samples for EM-based connectomics
Authors: Song Kun , Feng Zhihui , Helmstaedter Moritz 
Published: May 2023

AbstractConnectomes of human cortical gray matter require high-contrast homogeneously stained samples sized at least 2 mm on a side, and a mouse whole-brain connectome requires samples sized at least 5–10 mm on a side. Here we report en bloc staining and embedding protocols for these and other applications, removing a key obstacle for connectomic analyses at the mammalian whole-brain level.
Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells
Authors: Islam Mohammad Shahidul , Al-Majid Abdullah Mohammed , Sholkamy Essam Nageh , Barakat Assem , Viale Maurizio , Menichini Paola , Speciale Andrea , Loiacono Fabrizio , Azam Mohammad , Verma Ved Prakash , Yousuf Sammer , Teleb Mohamed 
Published: May 2023

AbstractRecently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment. This directed efforts to invest in designing various combinatorial libraries of spirooxindoles. Herein, we introduce new series of spirooxindoles via hybridization of the chemically stable core spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one and the pyrazole motif inspired by lead pyrazole-based p53 activators, the MDM2 inhibitor BI-0252 and promising molecules previously reported by our group. Single crystal X-ray diffraction analysis confirmed the chemical identity of a representative derivative. Fifteen derivatives were screened for cytotoxic activities via MTT assay against a panel of four cancer cell lines expressing wild-type p53 (A2780, A549, HepG2) and mutant p53 (MDA-MB-453). The hits were 8h against A2780 (IC50 = 10.3 µM) and HepG2 (IC50 = 18.6 µM), 8m against A549 (IC50 = 17.7 µM), and 8k against MDA-MB-453 (IC50 = 21.4 µM). Further MTT experiments showed that 8h and 8j potentiated doxorubicin activity and reduced its IC50 by at least 25% in combinations. Western blot analysis demonstrated that 8k and 8m downmodulated MDM2 in A549 cells. Their possible binding mode with MDM2 were simulated by docking analysis.
Reduced ability to neutralize the Omicron variant among adults after infection and complete vaccination with BNT162b2, ChAdOx1, or CoronaVac and heterologous boosting
Authors: Espíndola Otávio Melo , Fuller Trevon L. , de Araújo Mia Ferreira , Tort Luis Fernando Lopez , Guaraldo Lusiele , Calvet Guilherme , Resende Paola , Bonaldo Myrna , Whitworth Jimmy , Smith Chris , Siqueira Marilda , Brasil Patrícia 
Published: May 2023

AbstractCOVID-19 vaccines have dramatically reduced rates of severe infection requiring hospitalization. However, SARS-CoV-2 variants have reduced vaccine effectiveness at preventing any symptomatic infection. This real-world study analyzed binding and neutralizing antibodies generated after complete vaccination and boosting across three vaccine platforms. Binding antibodies decayed most slowly in people under 60 with hybrid immunity. Neutralizing antibodies against Omicron BA.1 were reduced compared to other variants. The anamnestic anti-spike IgG response to the first boost was more pronounced than after the second boost. Monitoring of the effects of SARS-CoV-2 mutations on disease severity and the effectiveness of therapeutics is warranted.
Attribution and driving force of nitrogen losses from the Taihu Lake Basin by the InVEST and GeoDetector models
Authors: He Xinghua , Tian Jiaming , Zhang Yanqin , Zhao Zihan , Cai Zucong , Wang Yanhua 
Published: May 2023

AbstractQuantifying temporal and spatial changes in reactive nitrogen (Nr) losses from a watershed and exploring its main drivers are the key to watershed water quality improvements. Huge Nr losses continue to threaten the safety of the water environment in the Taihu Lake Basin (TLB). Here, the InVEST and GeoDetector models were combined to estimate Nr losses in the TLB from 1990 to 2020 and explore driving forces. Different scenarios for Nr losses were compared, showing that Nr loss peaked at 181.66 × 103 t in 2000. The key factors affecting Nr loss are land use, followed by elevation, soil, and slope factors, and their mean q-values were 0.82, 0.52, 0.51, and 0.48, respectively. The scenario analysis revealed that Nr losses increased under the business-as-usual and economic development scenarios, while ecological conservation, increased nutrient use efficiency, and reduced nutrient application all contribute to a reduction in Nr losses. The findings provide a scientific reference for Nr loss control and future planning in the TLB.
Training a quantum measurement device to discriminate unknown non-orthogonal quantum states
Authors: Concha D. , Pereira L. , Zambrano L. , Delgado A. 
Published: May 2023

AbstractHere, we study the problem of decoding information transmitted through unknown quantum states. We assume that Alice encodes an alphabet into a set of orthogonal quantum states, which are then transmitted to Bob. However, the quantum channel that mediates the transmission maps the orthogonal states into non-orthogonal states, possibly mixed. If an accurate model of the channel is unavailable, then the states received by Bob are unknown. In order to decode the transmitted information we propose to train a measurement device to achieve the smallest possible error in the discrimination process. This is achieved by supplementing the quantum channel with a classical one, which allows the transmission of information required for the training, and resorting to a noise-tolerant optimization algorithm. We demonstrate the training method in the case of minimum-error discrimination strategy and show that it achieves error probabilities very close to the optimal one. In particular, in the case of two unknown pure states, our proposal approaches the Helstrom bound. A similar result holds for a larger number of states in higher dimensions. We also show that a reduction of the search space, which is used in the training process, leads to a considerable reduction in the required resources. Finally, we apply our proposal to the case of the phase flip channel reaching an accurate value of the optimal error probability.
Age-dependent differences and similarities in the plasma proteomic signature of postoperative delirium
Authors: Oren Rachel L. , Kim Erin J. , Leonard Anna K. , Rosner Bernard , Chibnik Lori B. , Das Sudeshna , Grodstein Francine , Crosby Gregory , Culley Deborah J. 
Published: May 2023

AbstractDelirium is an acute confusional state and a common postoperative morbidity. Prevalent in older adults, delirium occurs at other ages but it is unclear whether the pathophysiology and biomarkers for the condition are independent of age. We quantified expression of 273 plasma proteins involved in inflammation and cardiovascular or neurologic conditions in 34 middle-aged and 42 older patients before and one day after elective spine surgery. Delirium was identified by the 3D-CAM and comprehensive chart review. Protein expression was measure by Proximity Extension Assay and results were analyzed by logistic regression, gene set enrichment, and protein–protein interactions. Twenty-two patients developed delirium postoperatively (14 older; 8 middle-aged) and 89 proteins in pre- or 1-day postoperative plasma were associated with delirium. A few proteins (IL-8, LTBR, TNF-R2 postoperatively; IL-8, IL-6, LIF, ASGR1 by pre- to postoperative change) and 12 networks were common to delirium in both age groups. However, there were marked differences in the delirium proteome by age; older patients had many more delirium-associated proteins and pathways than middle-aged subjects even though both had the same clinical syndrome. Therefore, there are age-dependent similarities and differences in the plasma proteomic signature of postoperative delirium, which may signify age differences in pathogenesis of the syndrome.
Characterizing non-communicable disease trends in undocumented migrants over a period of 10 years in Italy
Authors: Fiorini Gianfrancesco , Franchi Matteo , Pellegrini Giacomo , Rigamonti Antonello Emilio , Sartorio Alessandro , Marazzi Nicoletta , Corrao Giovanni , Cella Silvano Gabriele 
Published: May 2023

AbstractUndocumented migrants represent a large part of the population in Countries of the European Union (EU) such as Italy. Their health burden is not fully understood and likely to be related mainly to chronic conditions. Information on their health needs and conditions may help to target public health interventions but is not found in national public health databases. We conducted a retrospective observational study of non-communicable disease (NCD) burden and management in undocumented migrants receiving medical care from Opera San Francesco, a non-governmental organization (NGO) in Milan, Italy. We analyzed the health records of 53,683 clients over a period of 10 years and collected data on demographics, diagnosis and pharmacological treatments prescribed. 17,292 (32.2%) of clients had one or more NCD diagnosis. The proportion of clients suffering from at least one NCD increased from 2011 to 2020. The risk of having an NCD was lower in men than women (RR = 0.88, 95% CI 0.86–0.89), increased with age (p for trend < 0.001) and changed with ethnicity. African and Asian migrants had a lower risk than Europeans of cardiovascular diseases (RR 0.62 CI 0.58–0.67, RR 0.85 CI 0.78–0.92 respectively) and mental health disorders (RR 0.66 CI 0.61–0.71, RR 0.60 CI 0.54–0.67 respectively), while the risk was higher in Latin American people (RR 1.07 CI 1.01–1.13, RR 1.18 CI 1.11–1.25). There was a higher risk of diabetes in those from Asia and Latin America (RR 1.68 CI 1.44–1.97, RR 1.39 CI 1.21–1.60). Overall, migrants from Latin America had the greatest risk of chronic disease and this was true for diabetes, cardiovascular diseases and mental health disorders. Undocumented migrants demonstrate a significantly different health burden of NCDs, which varies with ethnicity and background. Data from NGOs providing them with medical assistance should be included in structuring public health interventions aimed at the prevention and treatment of NCDs. This could help to better allocate resources and address their health needs.