bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protecting human amnion and chorion matrices during processing: Performance enhancement in a diabetic mouse model and human co‐culture system
Authors: Sanders Mitchell Corey , Balaji Swathi , Martin W. Blake , Siegmund Nikole , Poland Lindsay , Sanders Hanna Mia , Wei Da , Kaliada Hanna , Littlejohn Sara , Ganey Timothy 
Published: May 2023

AbstractRecent evidence suggests that protecting human amnion and chorion matrices (HACM) during processing enhances the performance of HACM for wound repair and tissue regeneration. We utilised a diabetic (db/db) delayed wound healing mouse model. Treatment of db/db full‐thickness excisional wounds with HACM, processed with a polyampholyte preservative accentuated the proliferative phase of wound healing that decreased the time necessary to heal wounds. Polyampholyte protection improved the preservation of growth factors and cytokines during room temperature storage following E‐beam sterilisation and improved its function in wound healing applications. Our findings indicate protected HACM tissue up‐regulated MIP2, NF‐kB, TNF‐α, KI‐67, and Arg1 (0.6‐fold to 1.5‐fold) but those changes were not statistically significant. Immunofluorescent assessment identifying cell activity illustrated an induction of the proliferative phase of wound healing and a switch from an inflammatory macrophage phenotype (M1) to a pro‐regenerative macrophage phenotype (M2a). Genomic profiling of 282 genes was performed using Nanostring from co‐cultures of human macrophages and fibroblasts. The polyampholyte + HACM‐treated group, compared with the HACM or polyampholyte alone groups, had a statistically significant up‐regulation (32–368 fold) of 12 genes primarily involved in macrophage plasticity including CLC7, CD209, CD36, HSD11B1, ICAM1, IL1RN, IL3RA, ITGAX, LSP1, and PLXDC2 (adj. p‐value < 0.05). The polyampholyte alone group demonstrated statistically significant down‐regulation of four genes ADRA2, COL7A1, CSF3, and PTGS2 (adj. p < 0.05). The HACM alone group up‐regulated four genes ATG14, CXCL11, DNMT3A, and THBD, but the results were not statistically significant. Biomechanical measurements indicated that wounds treated with polyampholyte‐protected HACM had more tensile integrity compared with wounds treated with HACM alone. These findings indicate that better protection of HACM during processing stabilises the HACM matrix, which may lead to improved wound healing outcomes.
Ancistroceruswasps (Hymenoptera, Vespidae) from the Centre of Europe: Phylogeny, cryptic species, neutral and non‐neutral markers
Authors: Budrys Eduardas , Orlovskytė Svetlana , Lazauskaitė Miglė , Budrienė Anna 
Published: May 2023

AbstractThe aim of the study was to clarify the phylogenetic relationships among Northern EuropeanAncistrocerusand comparison of the applicability of evolutionarily neutral and non‐neutral markers for reconstruction of phylogeny. We used a 19,400 bp long dataset that included parts of mitochondrial DNA, nuclear rDNA operon, and 10 nuclear protein‐coding genes. Application of molecular barcoding and species delimitation algorithms unveiled a presence of cryptic species,A. balticussp. n., in the trap‐nesting wasp communities of the centre of Europe. We assessed the morphological, biological, and ecological differences of it from the siblingA. trifasciatusand updated the regional identification key. Phylogeny reconstruction using the neutral and the presumably non‐neutral markers resulted in different tree topologies. Evolutionary congruence of the rDNA operon with the other markers was relatively low. Evolutionary rate of the mitochondrial genes was 7–8 times as high as that of the exons of the nuclear genes, therefore, the mitochondrial markers overshadowed the nuclear ones in the phylogeny reconstructions. We assumed that at the speciation level, we might consider two different patterns of phylogeny: one based on evolutionary time and neutral changes, and the other based on adaptive evolutionary pathways under directional selection pressures. We assessed the effect of directional selection on the nuclear protein‐coding genes, applying the Spearman's rank correlation between pairwise phylogenetic distances among species, estimated using exons, and these distances, estimated using introns. One of these markers demonstrated a lack of positive correlation, implying a variable directional selection pressure on the coded protein. The publication has been registered on ZooBank: urn:lsid:zoobank.org:pub:13BD28D0‐736D‐4B2A‐B5CF‐4824BD4CDCFB.
Design of a Reconfigurable Mobile Collaborative Manipulator for Industrial Applications
Authors: Baldassarri Alberto , Bertelli Michele , Carricato Marco 
Published: May 2023

Abstract
This paper addresses the design of a reconfigurable mobile manipulator consisting of a mobile base and a collaborative serial robot. The robotic system is meant to work in an industrial environment and perform different logistic tasks. Unlike commercial solutions, the mobile base and the anthropomorphic arm are free to decouple and work separately as two different entities, thus optimizing working times and maximizing the hardware utilization ratio. The proposed mobile manipulator is equipped with an automatic braking system to ensure safety and stability during manipulation, a lifting system that allows the robotic arm to work at different heights, and a spatial referencing process to compensate for positioning error of the mobile base. An illustrative working cycle is implemented in an industrially relevant environment to test all features and show potentialities, in terms of flexibility and reconfigurability, of the presented solution.
Targeted depletion of
pks
+ bacteria from a fecal microbiota using specific antibodies
Authors: Blanco-Míguez Aitor , Marcos-Fernández Raquel , Guadamuro-García Lucía , Fdez-Riverola Florentino , Cubiella Joaquín , Lourenço Anália , Margolles Abelardo , Sánchez Borja 
Published: May 2023

ABSTRACT

The
pks
island is one of the most prevalent pathogenicity islands among the
Escherichia coli
strains that colonize the colon of colorectal carcinoma (CRC) patients. This pathogenic island encodes the production of a nonribosomal polyketide-peptide named colibactin, which induces double-strand breaks in DNA molecules. Detection or even depletion of this
pks
-producing bacteria could help to understand the role of these strains in the context of CRC. In this work, we performed a large-scale
in silico
screening of the
pks
cluster in more than 6,000 isolates of
E. coli
. The results obtained reveal that not all the
pks
-detected strains could produce a functional genotoxin and, using antibodies against
pks
-specific peptides from surface cell proteins, a methodology for detection and depletion of
pks
+ bacteria in gut microbiotas was proposed. With our method, we were able to deplete a human gut microbiota of this
pks
+ strains, opening the door to strain-directed microbiota modification and intervention studies that allow us to understand the relation between these genotoxic strains and some gastrointestinal diseases.

IMPORTANCE

The human gut microbiome has also been hypothesized to play a crucial role in the development and progression of colorectal carcinoma (CRC). Between the microorganisms of this community, the
Escherichia coli
strains carrying the
pks
genomic island were shown to be capable of promoting colon tumorigenesis in a colorectal cancer mouse model, and their presence seems to be directly related to a distinct mutational signature in patients suffering CRC. This work proposes a novel method for the detection and depletion of
pks
-carrying bacteria in human gut microbiotas. In contrast to methods based on probes, this methodology allows the depletion of low-abundance bacterial strains maintaining the viability of both targeted and non-targeted fractions of the microbiota, allowing the study of the contribution of these
pks
-carrying strains to different diseases, such as CRC, and their role in other physiological, metabolic or immune processes.
Zircon-Based Comparative Geothermometry of the Adzh-Bogd Granitoid Pluton, Southern Mongolia
Authors: Andreeva O. A. , Aranovich L. Ya. , Kozlovsky A. M. , Golunova M. A. , Kaplanskaya D. D. , Borisovsky S. E. 
Published: May 2023

Abstract
The Adzh-Bogd pluton, that is located in the Transaltai Gobi area within the Hercynides of the Central Asian fold belt, is composed of rocks of two main intrusive phases: the early two feldspar granites are intruded by late alkali-feldspar granites. Zircon was chosen as the indicator mineral for interpretation of the thermal evolution of these granitoids. Two main approaches were proposed for using this mineral as a geothermometer: the zircon-saturated temperature and the Zr–Hf geothermometer. Both approaches show a similar pattern of the formation of granitoids. The early two feldspar and late alkali-feldspar granites crystallized at temperatures of 700–770 and 810–850°C, respectively. The thermobarogeochemical studies of melt inclusions in zircon from the late alkali-feldspar granites show similar temperatures of their formation (825–850°C). Our estimations of the crystallization temperature of granites of two phases of the Adzh-Bogd pluton indicate a significantly higher (by 100–120°C) temperature of the formation of alkali-feldspar granites in comparison with earlier two feldspar granites. The much higher temperature requires an additional heat source, which could be related to mantle melts. Their involvement in the formation of the Adzh-Bogd pluton is evident from the presence of mafic dikes, which divide the rocks of two granite intrusive phases. The contrasting temperature regime of nearly synchronous calc-alkaline and alkaline intrusive phases is shown for the first time in our work.
Magma Composition and Formation Conditions of Alkaline-Salic Rocks of the Early Mesozoic Adaatsag Bimodal Association of the Kharkhorin Rift Zone, Central Asia: Data from the Study of Melt Inclusions in Minerals
Authors: Andreeva I. A. , Yarmolyuk V. V. , Borisovsky S. E. 
Published: May 2023

Abstract
The composition and formation conditions of magmas of comendites of the Early Mesozoic Adaatsag volcanic association are determined using electron and ion microprobe analysis of melt inclusions, and mechanisms favorable for the accumulation of trace and rare earth elements are identified. The melt and fluid inclusions are found in quartz of comendites sampled in various parts of the section of a volcanic sequence. The melt inclusions consist of glass, a gas bubble, and daughter minerals (fluorite, polylithionite, and K-feldspar). The composition of a gas phase in melt inclusions was studied using Raman spectroscopy. The dominant gas phase components include water and hydrogen. The fluid inclusions are aqueous fluids probably corresponding to KF. The thermometric studies of melt inclusions and the analysis of glasses of homogenized melt inclusions in quartz phenocrysts of comendites showed that magmas crystallized from water-saturated rare metal melts with high Li, Zr, F, Rb, Nb, Y, and Th contents at a temperature of 880–930°C and a pressure of 1000 bar at a depth of ~3.5 km accompanied by degassing. The comparison of our data of the study of melt inclusions in phenocrysts of alkaline salic rocks of the coeval Adaatsag, Dzarta-Khuduk, and Sant volcanic associations, which occur within the Kharkhorin Rift Zone, revealed common principles of magma evolution. This allowed us to propose a similar mechanism of their formation, involving the accumulation of many rare and rare-earth elements, as well as volatile components (F, H2O) in the process of crystallization differentiation. Subsequently, a salt melt rich in Li, F and water could be separated from such comendite magmas. The detection of fluoride aqueous inclusions in quartz allows us to suppose the further evolution of the salt melt leading to the appearance of a concentrated aqueous fluid and the possible participation of the latter in metasomatic processes.
Effect of Sulfur Concentration on Olivine Sulfidation under Lithospheric Mantle PT-parameters
Authors: Bataleva Y. V. , Furman O. V. , Zdrokov E. V. , Borzdov Y. M. , Palyanov Y. N. 
Published: May 2023

Abstract
Experimental studies aimed at the modeling of interaction processes of sulfur-bearing metasomatic agents with mantle silicates and assessing the effect of sulfur concentration on olivine sulfidation were carried out in the Fe,Ni-olivine—sulfur system using the high-pressure multi-anvil apparatus BARS (1050 and 1450°C, 6.3 GPa, 40–60 h, sulfur concentrations (Xs) 0.1, 2, and 6 mol %). It has been established that as a result of the recrystallization of Fe,Ni-olivine in a sulfur melt, Fe and Ni are extracted from olivine into this melt, and formation of Fe,Ni-sulfides (or sulfide melts) and low-iron, low-nickel silicates takes place. The key indicator characteristics of the olivine sulfidation process are determined depending on the temperature and sulfur concentration, including characteristic phase assemblages, regularities in the evolution of the chemical compositions of mineral and melt phases, and structural features of olivine crystals. It has been experimentally established that reducing sulfur-bearing metasomatic agents, even in minimal concentrations and at relatively low temperatures, are capable of dissolving and transporting mantle silicates and sulfides, and can play an important role in sulfide ore formation in the mantle.
Geophysical Effects of the Active Stage of the Stromboli Volcano Eruption on October 9, 2022
Authors: Spivak A. A. , Loktev D. N. , Rybnov Yu. S. , Riabova S. A. , Tikhonova A. V. 
Published: May 2023

Abstract
The response of the microbaric background and variations in the Earth’s magnetic and electric fields to the paroxysmal activity of the Stromboli Volcano (October 9, 2022, Italy) was analyzed using the results of instrumental observations carried out in the surface atmosphere. The stage of active volcanic eruption was accompanied by the generation of an acoustic signal and pronounced variations in the geomagnetic and atmospheric electric fields at considerable distances both during the period of volcano activity and with the arrival of the infrasonic wave at the observation point. The volcanic eruption was noted to cause a response as critical frequency variations of the F2 layer in the ionosphere.
Regional Effects of Global Climate Changes in the Ural River Basin
Authors: Sivokhip Zh. T. , Pavleichik V. M. , Chibilyov A. A. 
Published: May 2023

Abstract
The study data obtained on regional climate changes (surface layer temperature and atmospheric precipitation) in the Ural River basin are reported for a 70-year period (1950–2020). Variations in the basic parameters of the regional climate in the basin studied were obtained by standard statistical data analysis, as well as by calculation of the integral climate anomaly indices. Statistically significant linear trend coefficients illustrate a steady increase in the average annual air temperature in the Ural River basin. The largest contribution to the growth of this parameter is made in the first three months of the calendar year (January–March) and the autumn months (October–November). The long-term course of precipitation values is devoid of unidirectional and statistically significant trends. The important macroregional trend is an increase in precipitation during the cold period. In conclusion, it should be noted that the diverse physical and geographical conditions of the regional climate are indicative of a spatially nonuniform response to the global and macroregional changes.
Copper Isotope Composition of Pt–Fe Minerals from the Nizhny Tagil Massif, Middle Urals: First Results
Authors: Malitch K. N. , Soloshenko N. G. , Votyakov S. L. , Badanina I. Yu. , Okuneva T. G. , Sidoruk A. R. 
Published: May 2023

Abstract
In order to provide further insights into the origin of Pt–Fe minerals, this study presents the first copper isotope data for Pt–Fe minerals from the Nizhny Tagil massif, an international standard of the zoned Ural-type complexes. The chemical and isotopic composition of Pt–Fe minerals were determined by electron microprobe analysis, chemical sample preparation with selective chromatographic separation of copper from a solution of the studied sample, followed by high-precision determination of the δ65Cu value using multiple-collector inductively coupled plasma mass-spectrometry. The majority of platinum group minerals (PGM) from chromitites of the Alexandrovsk Log and Krutoy Log deposits within the Nizhny Tagil massif are formed by Pt–Fe minerals, among which high-temperature ferroan platinum (Pt2Fe) containing subordinate inclusions of Os–Ir alloys and laurite (RuS2) predominate over other PGM. The concentrations of copper and δ65Cu values in the studied samples of ferroan platinum vary from 0.4 to 1.4 wt % Cu and from –0.37 to 0.26‰, respectively. Secondary low-temperature PGM assemblage is represented by the tetraferroplatinum (PtFe)—tulameenite (PtFe0.5Cu0.5) solid solutions series. The concentrations of copper in these PGM vary in the range of 6.8–11.3 wt %; the values of δ65Cu are characterized by lighter Cu-isotopic compositions ranging from –1.15 to –0.72‰. The lighter Cu-isotopic composition in secondary Cu-bearing PGM compared to that in ferroan platinum (δ65Cu = –1.01 ± 0.17‰, n = 8 and δ65Cu = 0.03 ± 0.23‰, n = 7, respectively) is consistent with a secondary nature of isotopic variations, due to evolved composition of the ore-forming fluid during the low-temperature formation of the tetraferroplatinum—tulameenite solid solution series.
Ensemble Modeling of Ice Sheet Dynamics in the Last Glacial Cycle
Authors: Ploskov A. N. , Eliseev A. V. , Mokhov I. I. 
Published: May 2023

Abstract
Ensemble simulations (taking into account to the uncertainty of paleoclimate reconstructions) with a model of ice sheet dynamics for the last glacial cycle (128 kyr) are carried out. In general, the model realistically reproduces the spatial structure of the ice sheets and the heights of their domes in the Northern Hemisphere, as well as the associated changes in the ocean level. Perturbations with a sufficiently large amplitude of paleoclimate data in the model show significant differences in the results of modeling the ice sheets of the Northern Hemisphere from the data obtained for the initial paleoreconstruction, including for the Last Glacial Maximum and the time interval of 58‒51 ka (the initial part of MIS3). According to the simulation results, the uncertainty of global reconstructions for the Last Glacial Maximum is 2°С, which is consistent with the existing estimates.
Ancilla-driven blind quantum computation for clients with different quantum capabilities
Authors: Dai Qunfeng , Quan Junyu , Lou Xiaoping , Li Qin 
Published: May 2023

AbstractBlind quantum computation (BQC) allows a client with limited quantum power to delegate his quantum computational task to a powerful server and still keep his input, output, and algorithm private. There are mainly two kinds of models about BQC, namely circuit-based and measurement-based models. In addition, a hybrid model called ancilla-driven universal blind quantum computation (ADBQC) was proposed by combining the properties of both circuit-based and measurement-based models, where all unitary operations on the register qubits can be realized with the aid of single ancilla coupled to the register qubits. However, in the ADBQC model, the quantum capability of the client is strictly limited to preparing single qubits. If a client can only perform single-qubit measurements or a few simple quantum gates, he will not be able to perform ADBQC. This paper solves the problem and extends the existing model by proposing two types of ADBQC protocols for clients with different quantum capabilities, such as performing single-qubit measurements or single-qubit gates. Furthermore, in the two proposed ADBQC protocols, clients can detect whether servers are honest or not with a high probability by using corresponding verifiable techniques.
Generalizing the relation between the Kauffman bracket and Jones polynomial
Authors: Kaiser Uwe 
Published: May 2023

We generalize Kauffman’s famous formula defining the Jones polynomial of an oriented link in [Formula: see text]-space from his bracket and the writhe of an oriented diagram [L. Kauffman, State models and the Jones polynomial, Topology 26(3) (1987) 395–407]. Our generalization is an epimorphism between skein modules of tangles in compact connected oriented [Formula: see text]-manifolds with markings in the boundary. Besides the usual Jones polynomial of oriented tangles we will consider graded quotients of the bracket skein module and Przytycki’s [Formula: see text]-analog of the first homology group of a [Formula: see text]-manifold [J. Przytycki, A [Formula: see text]-analogue of the first homology group of a [Formula: see text]-manifold, in Contemporary Mathematics, Vol. 214 (American Mathematical Society, 1998), pp. 135–144]. In certain cases, e.g., for links in submanifolds of rational homology [Formula: see text]-spheres, we will be able to define an epimorphism from the Jones module onto the Kauffman bracket module. For the general case we define suitably graded quotients of the bracket module, which are graded by homology. The kernels define new skein modules measuring the difference between Jones and bracket skein modules. We also discuss gluing in this setting.
The Impact of Judgment Variability on the Consistency of Offline Effectiveness Measures
Authors: Rashidi Lida , Zobel Justin , Moffat Alistair 
Published: May 2023

Measurement of the effectiveness of search engines is often based on use of relevance judgments. It is well known that judgments can be inconsistent between judges, leading to discrepancies that potentially affect not only scores but also system relativities and confidence in the experimental outcomes. We take the perspective that the relevance judgments are an amalgam of perfect relevance assessments plus errors; making use of a model of systematic errors in binary relevance judgments that can be tuned to reflect the kind of judge that is being used, we explore the behavior of measures of effectiveness as error is introduced. Using a novel methodology in which we examine the distribution of “true” effectiveness measurements that could be underlying measurements based on sets of judgments that include error, we find that even moderate amounts of error can lead to conclusions such as orderings of systems that statistical tests report as significant but are nonetheless incorrect. Further, in these results the widely used recall-based measures AP and NDCG are notably more fragile in the presence of judgment error than is the utility-based measure RBP, but all the measures failed under even moderate error rates. We conclude that knowledge of likely error rates in judgments is critical to interpretation of experimental outcomes.