bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender‐specific associations between types of childhood maltreatment and major depressive disorder: A matched case–control study
Authors: Zhou Jia , Feng Lei , Hu Changqing , Pao Christine , Zou Zhiyong , Wang Gang 
Published: June 2023

AbstractIntroductionMajor depressive disorder (MDD) has been found to be nearly twice as prevalent in females as in males. One hypothesis proposed that abused females were particularly prone to MDD. We aim to examine the sex‐specific associations between various types of childhood trauma and MDD.MethodsIn this study, 290 outpatients diagnosed with MDD were recruited from Beijing Anding Hospital, and 290 healthy volunteers were recruited from neighborhoods nearby the hospital, with sex, age, and family history matched. Childhood Trauma Questionnaire‐Short Form (CTQ‐SF) developed by Bernstein et al. was used to assess the severity of five different types of childhood abuse and neglect. McNemar's test and conditional logistic regression models with potential confounders (i.e., marital status, educational level, and body mass index) controlled were used to explore the sex‐specific associations between different types of childhood maltreatment and MDD.ResultsIn the full sample, patients with MDD showed a significant higher rate of any childhood maltreatment (i.e., emotional abuse, sexual abuse, physical abuse, emotional neglect, and physical neglect). Among females, all types of childhood abuse were statistically significant. For males, significant differences were only found in emotional abuse and in emotional neglect.ConclusionIt would appear that MDD in the outpatients is associated with any type of childhood trauma in women and emotional abuse or neglect in men.
Implementation of pharmacogenetic testing in medication reviews in a hospital setting
Authors: Hjemås Bodil Jahren , Bøvre Katrine , Bjerknes Kathrin , Mathiesen Liv , Mellingsæter Marte Christine Rognstad , Molden Espen 
Published: June 2023

AbstractAimTo investigate whether it is feasible to perform pharmacogenetic testing and implement the test results as part of medication reviews during hospitalization of multimorbid patients.MethodsPatients with ≥2 chronic conditions and ≥5 regular drugs with at least one potential gene‐drug interaction (GDI) were included from one geriatric and one cardiology ward for pharmacogenetic testing. After inclusion by the study pharmacist, blood samples were collected and shipped to the laboratory for analysis. For patients still hospitalized at the time when the pharmacogenetic test results were available, the information was used in medication reviews. Recommendations from the pharmacist on actionable GDIs were communicated to the hospital physicians, who subsequently decided on potential immediate changes or forwarded suggestions in referrals to general practitioners.ResultsThe pharmacogenetic test results were available for medication review in 18 of the 46 patients (39.1%), where median length of hospital stay was 4.7 days (1.6‐18.3). The pharmacist recommended medication changes for 21 of 49 detected GDIs (42.9%). The hospital physicians accepted 19 (90.5%) of the recommendations. The most commonly detected GDIs involved metoprolol (CYP2D6 genotype), clopidogrel (CYP2C19 genotype) and atorvastatin (CYP3A4/5 and SLCOB1B1 genotype).ConclusionsThe study shows that implementation of pharmacogenetic testing for medication review of hospitalized patients has the potential to improve drug treatment before being transferred to primary care. However, the logistics workflow needs to be further optimized, as test results were available during hospitalization for less than half of the patients included in the study.
Evaluation of doctors’ experience of psychodynamic psychotherapy training at Leeds and York Partnership NHS Foundation Trust during the COVID‐19 pandemic
Authors: Collin Gwenllian , Turner Oliver , Luthra Vikram 
Published: June 2023

Developing psychotherapeutic competencies is an essential part of psychiatric training. All Core Trainees at Leeds and York Partnership NHS Foundation Trust (LYPFT) saw a patient for psychodynamic psychotherapy until 2020. Due to the pandemic, all face‐to‐face appointments at the LYPFT Medical Psychotherapy Service were paused from March 2020. Patients could choose whether to continue therapy remotely or defer therapy. Supervision was also moved to a remote format. Face‐to‐face therapy sessions resumed from August 2020, with new infection control procedures. This project aimed to establish doctors’ experience of training in delivering psychodynamic psychotherapy at LYPFT during the pandemic. A two‐step methodology was used: an online survey including qualitative and quantitative analysis of the impact of the pandemic; and semi‐structured interviews with thematic analysis. The online survey had a response rate of 68%. Four patients deferred therapy; the mean deferral length was two months. Ten respondents had sessions cancelled due to infection/self‐isolation. Thirteen respondents (commencing therapy pre‐pandemic) delivered therapy face‐to‐face (without personal protective equipment [PPE]). During the pandemic five respondents delivered therapy via phone, six face‐to‐face with PPE. Thirteen were concerned about attaining psychotherapy competencies. Thematic analysis of the interviews identified three main themes (with subthemes). Challenges of delivering therapy during the pandemic were identified, as well as areas of good practice and opportunities.
LaSOM335, active against bladder cancer cells, interferes withLet‐60(hRas) and reducesCD73 expression/activity
Authors: Kagami Luciano Porto , Gonçalves Itamar Luís , da Silva Álisson Coldebella , Silva Aline Castro , das Neves Gustavo Machado , Göethel Gabriela , Spillere Adriano , dos Santos Maitê Roxo , Figueiró Fabrício , Garcia Solange Cristina , Ávila Daiana Silva , Battastini Ana Maria Oliveira , Eifler‐Lima Vera Lucia 
Published: June 2023

AbstractBladder cancer is the fourth most common malignancy in men. It can present along the entire continuum of severity, from mild to well‐differentiated disease to extremely malignant tumors with low survival rates. HumanRASgenes are the most frequently mutated oncogenes in human cancers, and the critical role of aberrant Ras protein function in carcinogenesis is well established. Therefore, considerable efforts have been devoted to the development of anti‐Ras inhibitors for cancer treatment. This study presents the biphenyl dihydropyrimidinone LaSOM 335 with high activity against T24 bladder cancer cells (IC50 = 10.73 ± 0.53 μM) and selectivity of cytotoxicity for this cancer cell line compared to two non‐cancer cell lines investigated. Furthermore, we also show that this compound reduced vulvar development in the mutantlet‐60 gene ofCaenorhabditis elegans.Let‐60 is a homolog of the mammalian Ras gene. In addition, we observed that LaSOM 335 inhibits the enzymatic activity of CD73 and decreases CD73 expression. Possibly, this expression decrease is due to downstream EGFR signaling via the Ras–Raf–ERK pathway, that directly regulates CD73 expression via ERK1/2. Evidence suggests that non‐immunomodulating functions of CD73 play an equally important role for cancer cell survival, progression, and migration. Regarding we also notice that LaSOM 335 was safe in the in vivo model ofC. elegans. The set of these findings makes this biphenyl dihydropyrimidinone a promising candidate for further investigations in the bladder cancer field.
Triangle Influence Supersets for Fast Distance Computation
Authors: Pujol Eduard , Chica Antonio 
Published: June 2023

AbstractWe present an acceleration structure to efficiently query the Signed Distance Field (SDF) of volumes represented by triangle meshes. The method is based on a discretization of space. In each node, we store the triangles defining the SDF behaviour in that region. Consequently, we reduce the cost of the nearest triangle search, prioritizing query performance, while avoiding approximations of the field. We propose a method to conservatively compute the set of triangles influencing each node. Given a node, each triangle defines a region of space such that all points inside it are closer to a point in the node than the triangle is. This property is used to build the SDF acceleration structure. We do not need to explicitly compute these regions, which is crucial to the performance of our approach. We prove the correctness of the proposed method and compare it to similar approaches, confirming that our method produces faster query times than other exact methods.
It is not always chlorhexidine: Identification of benzoxonium chloride and lauramine oxide as culprit allergens in a popular antiseptic in Switzerland
Authors: Wüthrich Héloïse , Yatim Ahmad , Di Lucca Julie , Walker Anna , Ventejou Sarah , Morren Marie‐Anne , Goossens An , Dendooven Ella , Aerts Olivier , Gilliet Michel , Seremet Teofila 
Published: June 2023

AbstractBackgroundA popular antiseptic spray in Switzerland (Merfen spray), containing chlorhexidine digluconate, benzoxonium chloride and lauramine oxide, is frequently used to treat skin wounds. However, it is also increasingly reported as a major cause of adverse skin reactions, including allergic contact dermatitis (ACD).ObjectivesTo investigate the contact allergens responsible for ACD from this antiseptic.Patients/MethodsPatch tests were performed on seven patients with a clinical history compatible with contact dermatitis from this antiseptic mixture.ResultsAll patients presented with acute eczematous reactions following contact with either Merfen spray alone, or with multiple products including this spray. Patients showed positive reactions to this product in both patch tests and repeated open application tests (ROATs). Four patients showed dose‐dependent reactions to both benzoxonium chloride and lauramine oxide. One patient showed a dose‐dependent reaction to the former and a non‐dose‐dependent reaction to the latter. Finally, two subjects showed responses only to lauramine oxide. One patient reacted to chlorhexidine digluconate 0.5% aq. in addition to both other allergens.ConclusionsTwo commercially unavailable allergens, that is, benzoxonium chloride and/or lauramine oxide were identified as major causes of ACD from Merfen antiseptic spray, whereas chlorhexidine digluconate was a contributing culprit in only one patient.
Weight change and risk of obesity‐related complications: A retrospective population‐based cohort study of a UK primary care database
Authors: MedSci Kamlesh Khunti F. , Schnecke Volker , Haase Christiane Lundegaard , Harder‐Lauridsen Nina M. , Rathor Naveen , Sommer Kasper , Morgen Camilla S. 
Published: June 2023

AbstractAimsTo examine associations between weight loss/gain and risk of developing 13 obesity‐related complications (ORCs), stratified by baseline body mass index (BMI).Materials and MethodsIn this retrospective cohort study, we included adults with obesity (>30 kg/m2) from the UK Clinical Practice Research Datalink GOLD database with weight change (−50% to +50%) between Years 1 and 4 (N = 418 774 [median follow‐up: 7 years]). Associations between weight change, baseline BMI and risk of developing ORCs during follow‐up were assessed using Cox proportional hazard models.ResultsThe impact of weight change on ORCs was generally dependent on baseline BMI. Four clear patterns were seen across the 13 outcomes. Pattern 1 showed greatest weight loss benefit for people with low baseline BMI (type 2 diabetes, sleep apnoea, hypertension and dyslipidaemia); Pattern 2 showed most weight loss benefit at lower baseline BMI but no significant weight loss effect at higher baseline BMI (asthma, hip/knee osteoarthritis and polycystic ovary syndrome); Pattern 3 showed benefit in most cardiovascular diseases with weight loss (chronic kidney disease, heart failure, atrial fibrillation and venous thromboembolism), but no additional benefit with >10% weight loss; Pattern 4 showed no clear relationship between weight change and unstable angina/myocardial infarction and depression. We found similar but opposite patterns for weight gain.ConclusionsWeight loss benefit is dependent on weight loss magnitude and initial BMI, and weight gain is associated with a similar risk increase. Four patterns of association were identified between degree of weight change, baseline BMI and 13 ORCs.
Designing a Startup Accelerator as Startup Journey and Business Model
Authors: Møller Jørn Kjølseth 
Published: June 2023

With a focus on international startups in the agricultural and food sector, the Danish startup accelerator Growth Train has been the subject of a detailed analysis concerning the service design of its startup journey and the business model behind the accelerator.An analysis of a Danish startup accelerator is described to understand better and improve the journey that new enterprises face in their early years.
All hat and no cattle: How house bill 2926 paves the way for progress in the reinstatement of parental rights, but falls short of providing parents with an accessible resource
Authors: Coffee Heather 
Published: June 2023

AbstractTexas' foster care system is overpopulated, underfunded, and doing a grave disservice to the children in its care. Specifically, the foster care system is violating the constitutional rights of children regarding how they must be taken care of while in the State's custody. Parents whose custodial rights were involuntarily terminated now have a clear path for petitioning to regain their rights thanks to Texas House Bill 2926. Much of House Bill 2926's value is lost in the legalese used to write it, which is the problem my proposed solution, The 2926 Project, aims to remedy.
Nonlocal approach to fatigue analysis of a welded bicycle frame joint
Authors: Tomaszewski Tomasz 
Published: June 2023

AbstractThe paper attempts to predict the probabilistic fatigue strength scatter bands of a welded bicycle frame joint. The experimental data of the base material and the weld material were approximated by a nonlinear probabilistic model of the Weibull distribution. The fatigue strength for the material at the fatigue crack location was estimated considering the mean stress, residual stress, fatigue notch factor, and hardness profile. The output finite element numerical data of the real welded joint were compared with a nonlocal multiaxial fatigue criterion. The implementation of the volumetric method takes into account the stress gradient effect in the three‐dimensional geometry of the weld toe. The comparative localization of the minimum stress and the real crack indicates the validity of the numerical model. The predicted fatigue strength determines the possible failure of a welded joint at 5·105 cycles.
No detectable upper limit of mineral‐associated organic carbon in temperate agricultural soils
Authors: Begill Neha , Don Axel , Poeplau Christopher 
Published: June 2023

AbstractSoil organic carbon (SOC) sequestration is a promising climate change mitigation option. In this context, the formation of the relatively long‐lived mineral‐associated organic carbon (MAOC) is key. To date, soils are considered to be limited in their ability to accumulate MAOC, mainly by the amount of clay and silt particles present. Using the comprehensive German Agricultural Soil Inventory, we selected 189 samples with a wide range of SOC (5–118 g kg−1) and clay contents (30–770 g kg−1) to test whether there is a detectable upper limit of MAOC content. We found that the proportion of MAOC was surprisingly stable for soils under cropland and grassland use across the whole range of bulk SOC contents. Soil texture influenced the slope of the relationship between bulk SOC and MAOC, but no upper limit was observed in any texture class. Also, C content in the fine fraction (g C kg−1 fraction) was negatively correlated to fine fraction content (g kg−1 bulk soil). Both findings challenge the notion that MAOC accumulation is limited by soil fine fraction content per se.
Emicizumab for acquired haemophilia A: A case series
Authors: Engelen Matthias M. , Vandesande Johan , De Bent Johan , Van Laer Christine , Labarque Veerle , Jacquemin Marc , Peerlinck Kathelijne , Hermans Cedric , Verhamme Peter , Vanassche Thomas 
Published: June 2023

AbstractBackgroundEmicizumab is approved to prevent bleeding in patients with congenital haemophilia A with or without inhibitors. However, no randomized trials addressed the efficacy of emicizumab in acquired haemophilia A (AHA).AimsTo report the clinical and biochemical response of emicizumab in AHA.MethodsThis single‐centre retrospective study included seven adults with AHA between November 2020 and May 2022. We collected patient characteristics, laboratory coagulation parameters, the use of haemostatic agents, bleeds and thrombotic events. Treatment was monitored using chromogenic FVIII assays. The assay with human reagents assesses both the emicizumab FVIII‐like‐activity and native patient FVIII‐activity. The assay with bovine reagents only measures the patients’ native FVIII‐activity as emicizumab does not bind to bovine reagents.ResultsPatients presented with spontaneous hematoma (n = 7), intramuscular bleeding (n = 2), haematuria (n = 2) and/or gastro‐intestinal bleeding (n = 2). Six patients had major bleedings. At diagnosis, APTT was prolonged (91 seconds, IQR 73–103), FVIII activity was 0% (IQR 0–1) and FVIII inhibitor 182 BU/mL (IQR 104–228). Emicizumab was administered weekly (3 mg/kg) for 4 weeks, and thereafter every 2 weeks until regression of the inhibitor. Three patients received activated FVIIa (cumulative dose of 1.7 mg/kg, IQR 1.2‐2.2). All bleedings were controlled after treatment initiation, without further bleeds. After starting emicizumab, FVIII‐like activity reached ≥5% at 12 days (IQR 7–14), whereas recovery of the intrinsic FVIII‐activity ≥5% occurred at 128 days (IQR 88–173), coinciding with the disappearance of the FVIII inhibitor. There were no safety issues.ConclusionIn this AHA case series, no new clinically relevant bleeds were observed after initiation of emicizumab in conjunction with standard immunosuppressive therapy.
Profiling endogenous, environmental, and infectious disease mutational signatures in blastic plasmacytoid dendritic cell neoplasms
Authors: Small Corinn , Mukerjee Soham , Jangam Diwash , Gollapudi Sumanth , Singh Kunwar , Jaye David L. , Aung Phyu P. , Querfeld Christiane , Yao Keluo , Chisholm Karen M. , Pullarkat Sheeja , Wang Sa , Gru Alejandro , Hussaini Mohammad , George Tracy I. , Ohgami Robert S. 
Published: June 2023

AbstractBackgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic disease derived from plasmacytoid dendritic lineage cells. The disease typically shows skin as well as frequent bone marrow and peripheral blood involvement. However, the pathogenesis of this disease is still not well understood. While somatic point mutations and genetic rearrangements have been described in BPDCN, the types and origins of these mutations and relationships to other cancer types is not well understood.Materials and MethodsTo probe the origins of BPDCN, we analyzed the exome sequence data of 9 tumor‐normal pair cases of BPDCN. We utilized SignatureAnalyzer, SigProfiler and a custom microbial analysis pipeline to understand the relevance of endogenous and environmental mutagenic processes.ResultsOur results identified a significant tobacco exposure and aging genetic signature as well as signatures related to nucleotide excision repair deficiency, ultra violet (UV) exposure, and endogenous deamination in BPDCN. We also assessed the samples for microbial infectious disease organisms but did not find a link to a microbial etiology.ConclusionThe identification of a tobacco exposure and aging genetic signature in patients with BPDCN suggests that environmental and endogenous genetic changes may be central to the oncogenesis of BPDCN.
Effectiveness and complications of transcrestal sinus floor elevation using the cushioned grind‐out technique: A retrospective cohort study with up to 7 years of follow‐up
Authors: Gao Jiayu , Yin Wumeng , Liu Yeyu , Zhao Xiangqi , Qu Yili , Man Yi 
Published: June 2023

AbstractAimTo evaluate the effectiveness and complications of the cushioned grind‐out technique. The primary outcome was endo‐sinus bone gain (ESBG), while secondary outcomes included the Schneiderian membrane perforation rate and mid‐ to long‐term implant survival.Materials and MethodsIn this retrospective study, we compared the cushioned grind‐out technique with the classic osteotome technique, establishing statistical models to assess ESBG, membrane perforation rate and implant survival rate.ResultsA total of 259 patients and 340 implants were included. The mean ESBG was 5.31 mm for the cushioned grind‐out group and 4.64 mm for the osteotome group. Multivariable regression analysis revealed that the cushioned grind‐out technique significantly facilitated ESBG (p = .028). Nineteen preparation sites experienced membrane perforation, with rates of 5.5% and 6.4% for the cushioned grind‐out and osteotome groups, respectively. However, the difference was not statistically significant (p = .920). Additionally, the cumulative survival rate of the implants for 7 years was 95.2% and 91.4%, respectively, with the surgical technique not significantly influencing the results.ConclusionsWith 6 months to 7 years of post‐prosthetic restoration review data, our findings show that the cushioned grind‐out technique facilitates a higher ESBG, with no significant difference in membrane perforation or implant failure rate.
Monitoring and characterization of field‐evolved resistance to diamide insecticides in Spodoptera litura collected from eastern China
Authors: Che Wunan , Li Yunyi , Zhang Daofeng , Qu Cheng , Luo Chen , Wang Ran 
Published: June 2023

AbstractSpodoptera litura is a notoriously destructive pest, which infests horticultural plants and economically important crops worldwide. Several generations of diamide insecticides have been used to combat S. litura throughout the world, causing various levels of resistance to this class of insecticides among wild S. litura populations. In this work, we monitored resistance to five diamide insecticides among 10 S. litura populations sampled from eastern China in 2022. In comparison with Lab‐S the susceptible strain, five of the tested populations displayed high susceptibility to three of the five diamide insecticides (cyantraniliprole, broflanilide and tetraniliprole). In contrast, there was significant resistance to the other two tested diamide insecticides, flubendiamide and chlorantraniliprole, in seven of the field‐collected populations. The Shanghai (SH) population showed high resistance to chlorantraniliprole (77.0‐fold), flubendiamide (25.5‐fold) and cyantraniliprole (27.8‐fold), respectively, than the strain of Lab‐S. Results of synergism tests in the SH population revealed that diethyl maleate (DEM) and piperonyl butoxide (PBO) greatly inhibited chlorantraniliprole resistance. The progeny of reciprocal crosses between the Lab‐S and SH populations presented dominance degrees of F1 progenies, suggesting that the chlorantraniliprole resistance was autosomal and incompletely recessive in SH. Above results of the current work offer useful knowledge for future formulation of field pest management strategies, allowing farmers to delay the development of resistance to diamide insecticides and thus promote sustainable management of S. litura.