bluuebunny/crossref_metadata_2025_split huggingface dataset:
DONSON is required for CMG helicase assembly in the mammalian cell cycle
Authors: Evrin Cecile , Alvarez Vanesa , Ainsworth Johanna , Fujisawa Ryo , Alabert Constance , Labib Karim P.M. 
Published: August 2023

AbstractDONSON is one of 13 genes mutated in a form of primordial microcephalic dwarfism known as Meier-Gorlin Syndrome. The other 12 encode components of the CDC45-MCM-GINS helicase, around which the eukaryotic replisome forms, or are factors required for helicase assembly during DNA replication initiation. A role for DONSON in CDC45-MCM-GINS assembly was unanticipated, since DNA replication initiation can be reconstitutedin vitrowith purified proteins from budding yeast, which lacks DONSON. Using mouse embryonic stem cells as a model for the mammalian helicase, we show that DONSON binds directly but transiently to CDC45-MCM-GINS during S-phase and is essential for chromosome duplication. Rapid depletion of DONSON leads to the disappearance of the CDC45-MCM-GINS helicase from S-phase cells and our data indicate that DONSON is dispensable for loading of the MCM2-7 helicase core onto chromatin during G1-phase, but instead is essential for CDC45-MCM-GINS assembly during S-phase. These data identify DONSON as a missing link in our understanding of mammalian chromosome duplication and provide a molecular explanation for why mutations in human DONSON are associated with Meier-Gorlin syndrome.
Can national productions replace imports in West African countries? Estimation of the Marshall–Lerner–Robinson condition (MLRC)
Authors: Oloukoi Laurent 
Published: August 2023

PurposeThis article examines if the national productions of West African Economic and Monetary Union (WAEMU) countries can be substituted for the imports by testing MLRC in these countries.Design/methodology/approachThe Mundell–Fleming model (MMF) is the analytical framework adopted in this paper with import demand and export supply functions estimation borrowed to Thirlwall (1979). This study covers four countries in West Africa from 1990 to 2021. The estimation procedure used is an Autoregressive Distributed Lag (ARDL) approach to cointegration.FindingsThe findings reveal that there is a strong marginal propensity to import in the WAEMU countries. The hypothesis of a non-significant price effect on imports in the short-term is confirmed for several countries while only Togo satisfies the MLRC in the short and long run.Originality/valueThis study presents several originalities: (1) it evaluates MLRC with a clear analytical framework; (2) unlike other studies, this article quantifies the MLRC from a theoretical, econometric and empirical point of view; (3) this article presents the results country by country in order to reveal heterogeneity between countries; (4) this study adds to the Marshall–Lerner condition for the derivation of Robinson by considering a situation where initially the trade balance is not in equilibrium.
The future of work: A hybrid work model in a public sector organisation
Authors: Malila Cecilia , Daya Preeya , Bick Geoff 
Published: August 2023

Subject area of the teaching case:
This teaching case covers aspects of leadership development, strategy, change management, organisational behaviour, and people management. The case explores the following themes:

Workplace transformation and culture: the challenges and opportunities of remote/hybrid work in large government enterprises and maintaining the culture when moving remote
Leadership and change: the different perspectives that a leader can take into consideration when leading the business during turbulent and uncertain times and managing the change process in large organisations
Strategic decision-making: the application of analytical skills by senior management when making strategic decisions in a business

Student level:
The primary audience for this teaching case is management education programmes including: Master of Business Administration (MBA), Postgraduate Diploma (PGDip), specialist Masters in Management, and certain Executive Education programmes.

Brief overview of the teaching case:
This case deals with a public-sector entity that collects taxation revenue for the South African government. In 2020, the operations of this public entity are severely affected by the Covid-19 pandemic. The mandatory shift of the workforce from in-office to a remote work-from-home set-up, results in the entity switching to a hybrid work model in order to achieve its goals as an essential service. Protagonist Dr Zanele Twazi, executive head of the public entity's research department, is tasked by the commissioner to conduct a review on the hybrid work model. As the commissioner is also in the process of reviving the GSB: 2023-1 The future of work: A hybrid work model in a public sector organisation 2 organisational culture to regain public trust following multiple corruption scandals, the pandemic adds to this pressure. Dr Twazi must share employee feedback on the remote work option. Meanwhile, the leadership team has to decide if the work model will serve this public entity in achieving its strategy, and from an organisational culture viewpoint, if it is the best fit for the future.

Expected learning outcomes:
The key learnings from this case include the following:

Organisational work model: A suitable work model is dependent on the organisational mandate as well as its culture.
Culture and organisational goals: An organisational work model additionally impacts the future sustainability of the organisation and its ability to achieve its short- and long-term goals.
Change management framework: For teams to effectively adapt to a hybrid work model, managers have to be empowered to lead and be able to facilitate the change.
Does e-government development moderate the impact of female labor participation on national cybersecurity maturity? An empirical investigation
Authors: Dev Manimay , Saha Debashis 
Published: August 2023

Purpose
This paper aims to investigate the relationship of female participation in labor force with the cybersecurity maturity of nations and the enabling role of e-government development in moderating the same.

Design/methodology/approach
The authors have conducted fixed-effects regression using archival data for 149 countries taken from secondary sources. Furthermore, the authors have grouped the sample countries into four levels of cybersecurity maturity (unprepared, reactive, anticipatory and innovative) using clustering techniques, and studied the influence of their interest variables for individual groups.

Findings
Results show that female participation in labor force positively influences national cybersecurity maturity, and e-government development positively moderates the said relationship, thereby enabling the empowerment of women.

Practical implications
Encouraging broader participation of women in the labor force and prioritizing investments in e-government development are essential steps that organizations and governments may take to enhance a country’s cybersecurity maturity level.

Originality/value
This study empirically demonstrates the impact of the nuanced interplay between female participation in labor force and the e-government development of a nation on its cybersecurity maturity.
Examining the attitudes towards further education of students in the bachelor training programmes of higher education
Authors: Cseh-Papp Imola , Varga Erika , Juhász Tímea 
Published: August 2023

PurposeBased on empirical data, this study investigates the intention of BA/BSc students in higher education to either pursue their studies or start working.Design/methodology/approachThis paper analyses how students' attitudes towards higher education and studying (quality of undergraduate education and performance in higher education), as well as the intention to meet labour market needs, influence the decision of pursuing studies in a Master's programme.FindingsThe main reason why respondents do not intend to pursue their studies is not because they do not want to work. It is primarily the acquisition of knowledge and the motivation to learn that encourages students to stay in higher education. Moreover, individual performance in Bachelor programmes has no influence on the decision made by students to study or work after graduation.Research limitations/implicationsAs for the limitations of the study, the authors have to mention that although the survey is based on data from a single country, the similarity of the international and Hungarian previous research results suggests that similar results would have been obtained in an international sample. Furthermore, the impact of the current ongoing epidemic on the further learning of young people in tertiary education at primary level could not be investigated by the authors.Practical implicationsThe bivariate logistic regression results show that the correlation between secure job placement in a field of study and the quality of education is not significant. Furthermore, students are primarily motivated by the desire to learn and acquire knowledge. The reasons can therefore be explored based on the analysis of more detailed data, which could be the subject of a subsequent study.Originality/valueThe authors conducted their research in Hungarian higher education at seven universities between 2019 and 2020 to determine the influencing factors of career choice decisions, the degree of students' satisfaction with their selected course, their attitude towards higher education and learning, their job opportunities after graduation and the extent to which their decision is made according to their labour market orientation. Although the study relies on data from a single nation, the similarity between the findings of previous international (Hovdhaugen and Ulriksen, 2021; Sikyr et al., 2019); and Hungarian (Berezvai, 2022; Kiss and Varga, 2022) research suggests that an international sample would have produced similar results.
Sequencing statements: using behaviour sequence analysis with statement analysis to indicate deception
Authors: Richards Yasmin , McClish Mark , Keatley David 
Published: August 2023

Purpose
Understanding when an individual is being deceptive is an important part of police and criminal investigations. While investigators have developed multiple methods, the research literature has yet to fully explore some of the newer applied techniques. This study aims to investigate statement analysis, a recent approach in forensic linguistic analysis that has been applied to criminal investigations.

Design/methodology/approach
Real-world statements of individuals exposed as deceptive or truthful were used in the analyses. A behaviour sequence analysis approach is used to provide a timeline analysis of the individuals’ statements.

Findings
Results indicate that sequential patterns are different in deceptive statements compared to truthful statements. For example, deceptive statements were more likely to include vague words and temporal lacunas, to convince investigators into believing that the suspect was not present when the crime occurred. The sample in this research did not use one deceptive indicator, instead, electing to frequently change the order of deceptive indicators. Gaps in deception were also noted, and there was common repetition found in both the deceptive and truthful statements. While gaps are predicted to occur in truthful statements to reflect an absence of deception, gaps occurring in the deceptive statements are likely due to cognitive load.

Originality/value
The current research provides more support for using statement analysis in real-world criminal cases.
The effect of Islamic attributes, destination image, scepticism, perceived value and halal awareness on the intention to engage in Muslim-friendly travel
Authors: Rostiani Rokhima , Firdausi Asri Sekar Mawar , Arini Hilya Mudrika , Mulyani Yun Prihantina , Sunarharum Tri Mulyani 
Published: August 2023

Purpose
This study aims to empirically test the influence of pull factors on the intention to engage in Muslim-friendly travel. This study proposes a distinct path between Islamic attributes and emotional value and scepticism, along with destination image and its functional value. This study also proposes the role of halal awareness in moderating the relationship between Islamic attributes and scepticism.

Design/methodology/approach
This study used a quantitative approach using an online survey. The authors purposively selected younger individuals who had travelled inside the country at least three times during the past five years. With a total of 416 valid responses, this study used variance-based partial least squares to test the hypotheses.

Findings
The results show that intention to engage in Muslim-friendly travel is positively influenced by emotional and functional values, but negatively by scepticism. Emotional value and scepticism are influenced by Islamic attributes, whereas functional value is influenced by destination image. More specifically, halal awareness is proven to moderate the relationship between Islamic attributes and scepticism, in which individuals with a higher level of halal awareness tend to be less sceptical about halal offerings.

Originality/value
This study supports a previous study in which emotional and functional values are considered differently by consumers. Furthermore, the dual role of Islamic attributes, as pull factors, is confirmed, providing a deeper understanding of its influence on emotional value and scepticism. To the best of the authors’ knowledge, this study is also the first to investigate the role of halal awareness in increasing the level of scepticism among Muslim consumers.
Faculty perceptions of online presence: intercultural considerations
Authors: Yousef Dima , Takshe Aseel A. , Contu Davide 
Published: August 2023

Purpose
The Covid-19 pandemic forced educational institution to rapidly switch to online delivery. Even if the pandemic seems to be over, online learning will continue to constitute at least a part of the course’s delivery in the future. With that in mind, this study aims to explore the factors that influence teaching presence online and how these perceptions will guide teachers to adopt practices that will impact their presence accordingly. Given the changes implemented due to the pandemic, this study is essential to identify the significance of teaching and social presence in online classes.

Design/methodology/approach
Semi-structured interviews were used to find answers to the posed research questions. Exploring the perceptions and experiences of four university teachers, this study, informed by the community of inquiry (CoI) model, investigated the impact of teaching and social presence on the online learning experience in higher education.

Findings
The findings indicate that teachers acknowledged the importance of these two elements in teaching online. Moreover, the study investigates how teachers could establish teaching and social presence to enhance the online learning experience.

Originality/value
The study explores teachers’ views on the importance of presence, their practices to achieve in an online learning environment and addresses a gap in the literature on “teaching presence from the educator’s perspective, [since] most studies exploring the student’s perspective” (Gurley, 2018, p. 200).
Investigating the asymmetric impact of renewable energy consumption and trade openness for carbon emission abatement using N-ARDL approach: a case of India
Authors: Roy Hiranmoy , Rej Soumen , Rajaiah Jayaraj 
Published: August 2023

PurposeThis study investigates the asymmetric influence of renewable energy consumption (REC) and trade openness (TO) in the pathway of decarbonizing of Indian economy.Design/methodology/approachBy exploiting fifty years of annual time series data spanning from 1970 to 2019 with the augmentation of nonlinear autoregressive distributed lag technique with the consideration of GDP and industry value added (IVA) as control variables.FindingsOur This research not only demonstrates the asymmetric association among the employed variables but also shows that negative shock to REC stimulates emissions, where as positive shock on the same policy variable promotes environmental quality improvement. Negative shock to TO is found to be associated with the corresponding increase of environmental quality, but the positive shock on the same intensifies environmental pollution. IVA is also found to be associated with intensifying environmental squalor. In addition, the research provides the empirical evidence of existence of “EKC” hypothesis in India as long-run coefficient associated with GDP looks smaller than short-run coefficient of GDP.Research limitations/implicationsIt was difficult to include may other causal variables due to nonavailability of data pertaining to those variables.Practical implicationsMoreover, some policy guidelines have also been recommended for India at the end that may aid India to achieve net zero emissions by 2070.Originality/valueThis is an original research paper carried out by the authors and has not yet been submitted elsewhere.
Current status of low‐density lipoprotein apheresis treatment for patients with peripheral artery disease and chronic kidney disease in Japanese clinical database
Authors: Watanabe Yu , Tanaka Akihito , Furuhashi Kazuhiro , Maruyama Shoichi 
Published: August 2023

AbstractIntroductionPatients with peripheral arterial disease (PAD) have a poorer prognosis than those without PAD. PAD complications worsen the prognosis of patients with chronic kidney disease (CKD), especially those on maintenance dialysis. Although low‐density lipoprotein apheresis (LDL‐A) is expected to be effective in treating severe PAD, there are no large‐scale reports on the prognosis of patients undergoing LDL‐A.MethodsWe obtained a clinical database from April 2008 to August 2021 and selected 924 238 patients with CKD. We selected patients with disease codes of lower limb arteriosclerosis obliterans, arteriosclerosis obliterans, and critical limb ischemia or foot ulcer. Patients who were prescribed antithrombotic medications were included. Patients who used steroids were excluded. Among these patients, those undergoing blood purification considered LDL‐A were selected, and their current status was investigated.ResultsWe included 147 patients (113 males and 34 females). The mean patient age was 70 ± 10 years. Diabetes mellitus was present in 86%, ischemic heart disease in 34%, and stroke in 48%. Maintenance dialysis patients accounted for 86% of the patients. Statins were administered to 40% of the patients, and bypass surgery was performed in 2.7%. The median observation period was 812 days, and the mortality rate was 41%.ConclusionLDL‐A was performed in a small population of patients with CKD with the most severe form of PAD. The prognosis for these patients is extremely poor. Therefore, strategies to improve prognosis are important.
A case of severe paraneoplastic glutamic acid decarboxylase antibody‐spectrum disorder with improvement through prior immunotherapy before surgical intervention
Authors: Nozuma Satoshi , Yuji‐Takeuchi Mika , Nakamura Tomonori , Saigo Ryuji , Masuda Mirai , Ando Masahiro , Sakiyama Yusuke , Miyata Ryo , Tabata Kazuhiro , Matsuura Eiji , Takashima Hiroshi 
Published: August 2023

AbstractBackgroundInitially associated with stiff‐person syndrome, antibodies to glutamic acid decarboxylase (GAD) antibodies are now recognized as indicators of GAD antibody‐spectrum disorders (GAD‐SD), which encompass cerebellar ataxia, autoimmune epilepsy and limbic encephalitis. Paraneoplastic neurological syndromes associated with GAD‐SD are rare, and optimal timing of surgical intervention and impact on neurological symptoms remain poorly understood.Case PresentationWe present the case of a 65‐year‐old woman who developed overlapping symptoms of cerebellar ataxia and stiff‐person syndrome detected through high‐titer GAD antibodies in both serum and cerebrospinal fluid, alongside the presence of a thymoma. Due to severe dysphagia and gait ataxia that rendered her bedridden on admission, surgical intervention was initially deferred. Instead, she received immunotherapies including intravenous methylprednisolone and intravenous immunoglobulin, which remarkably improved neurological symptoms. However, a decline in symptoms occurred on tapering oral prednisolone. Subsequently, a thoracoscopic thymectomy was carried out 27 months after symptom onset, leading to further neurological improvement and successful reduction of prednisolone.ConclusionIn paraneoplastic GAD‐SD cases with severe symptoms at presentation, prioritizing immunotherapy and considering surgical intervention once the symptoms have stabilized might be advantageous.
Postherpetic granulomatous dermatitis occurring in the setting of immune checkpoint inhibitor therapy: A case report
Authors: Hetzel John D. , Diamond Davis C. , Ramsey Zachary C. , Henson John W. , Powell Matthew R. 
Published: August 2023

AbstractWe report a case of a 72‐year‐old man presenting with a 2‐month history of a persistent, painful rash of the chest, axilla, and back. He had a history of recently resolved varicella zoster virus reactivation in the same distribution of the current rash and metastatic malignant melanoma treated with nivolumab and ipilimumab. The histopathology was consistent with granulomatous dermatitis (GD), and a diagnosis of postherpetic isotopic response manifesting as GD was made. Given the paucity of reported cases of postherpetic GD in the setting of treatment with immune checkpoint inhibitors (ICIs), we discuss the clinicopathologic features of this case and potential mechanisms by which ICIs may contribute to the development of granulomatous disease.
High‐throughput sequencing of maize dwarf mosaic virus from common reed in a wetland
Authors: Ilbağı Havva , Masonbrink Rick , Miller W. Allen 
Published: August 2023

AbstractCommon reed is a widespread aquatic grass in wetland areas of Turkey. In reed samples, RNAs with the sequence of the Maize dwarf mosaic virus (MDMV) were found using high‐throughput sequencing. The nearly complete genome sequence comprised 9514 nucleotides. It contains a 5′ UTR of at least 145 nucleotides, a 3′ UTR of at least 237 nucleotides, and an ORF encoding a single polyprotein of 3041 amino acid residues. Two partial sequences were 7709 nt and 7858 nt long, respectively. Three reed sequences contained 22 nt, 25 nt, and 80 nt insertions in the 5′UTR, respectively. The coding region of MDMV TR‐34 (49%) was more conserved than UTRs (34.3%) compared to Johnsongrass mosaic virus (JGMV), Sugarcane mosaic virus (SCMV), and Sorghum mosaic virus (SrMV). MDMV‐TR34 reed isolate shares 91%–53.1% nucleotide identity and 98.2%–49% amino acid sequence similarity with other MDMV and three potyvirus sequences, respectively. Recombination analysis indicated six putative recombination events. In 2020–2022, the survey studies showed that 25 of 260 reed samples were infected with MDMV at the infection rate of 9.6% in Tekirdag province. This result is the first report of the complete nucleotidesequence of MDMV in the common reed, a reservoir host for cereals growing areas in Turkey.