bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium-Catalyzed Borylation of Aryl Halides in Water Using Poly (Ethylene Glycol)-Based Surfactants
Authors: Suzuki Noriyuki , Okajima Kanata , Takayama Daijiro , L. Silkenath Bjarne , Yang Zheng , Takeoka Yuko , Rikukawa Masahiro 
Published: January 2025

Background:
Developing environmentally benign processes, such as organic reactions
conducted in water, is desired from the view of sustainable technology. Concerning the palladiumcatalyzed
borylation reactions of aryl halides in water, only a few examples have been reported.

Objective:
This study aimed to develop efficient methods for palladium-catalyzed borylation reactions
of aryl halides in water, not only increasing product yields but also extracting products with
less organic solvents.

Methods:
We adopted polymer surfactants, such as diblock copolymers that consist of poly(Nisopropoylacrylamide)
and a hydrophilic segment, and a poly(ethylene glycol)-based polymer that
consists of poly(ethylene glycol) chain and 4-chloromethylbenzyl moiety.

Results:
Reactions using these polymers gave the borylation products in significantly higher yields
than that in pure water. The efficiency of the extraction process for the products from the reaction
mixtures was evaluated, indicating that the polymer micelles enabled separation processes with less
organic solvent.

Conclusion:
Applying polymer surfactants increased the product yields in Pd-catalyzed borylation
of aryl halides, and it enabled the extraction of the products from the aqueous reaction mixture more
efficiently.
Optimization Removal of Cd (II) from Aqueous Solution by Exhausted Kahwa Coffee Biochar under Various CarbonizationParameters
Authors: Yanti Nika R. , Puari Aninda T. , Rusnam Rusnam , Putri Irriwad 
Published: January 2025

Introduction:
Recently, abundant agricultural solid waste has been utilized as
sustainable biosorbents for removing heavy metals from aqueous solutions. However, the
influence of the carbonization parameters on the specified biosorbent performance has not
been well discussed. In this study, we developed the removal efficiency (RE) of Exhausted
Kahwa Coffee (EKC) as a low-cost and high-efficiency biosorbent for Cd (II) under various
carbonization temperatures (300 - 600 °C) and time (1- 4h).

Method:
The batch biosorption test showed that the EKC biochar with a carbonization
temperature of 500 °C and time of 4 h removed 97% of Cd (II) from the solution. The biosorption
performance was further investigated by integrating the physicochemical changes
in the surface and functional groups of the EKC biochar at different temperatures using
BET, SEM, and FT-IR instruments.

Results:
The FT-IR showed alterations in the functional groups, while the BET data and
SEM images demonstrated that the porous surface of the biochar developed as the temperature
increased. Furthermore, the biosorption test data was plotted in the Langmuir and
Freundlich isotherm models, where the Langmuir isotherm model showed the better fit of
EKC biochar. The maximum biosorption capacity of the EKC biochar on Cd (II) was calculated
at 3.41 mg/g by fitting the equilibrium data to Langmuir isotherm equations.

Conclusion:
It was found that the kinetic data fitted well with Pseudo-Second-Order (PSO)
with a correlation coefficient of R2 = 0.99. These findings imply the influence of the carbonization
parameter on the potential biosorption of the EKC biochar on Cd (II).
Faktor determinan risiko kardiometabolik pada remaja usia 15-18 tahun
Authors: Wiboworini Budiyanti , Shabrina Amalina , Dewi Yulia Lanti Retno , Sari Amelya Augusthina Ayu , Handayani Sutartinah Sri , Damayanti Kusmadewi Eka , Azzahrah Aisyah , Tjung Vivienne 
Published: January 2025

Determinant factors of cardiometabolic risk in adolescents aged 15-18 yearsBackground: Cardiometabolic diseases are increasing worldwide, and the risk of developing them starts as early as adolescence. In the long term, they may lead to comorbidities. Evidence suggests the risk factors of cardiometabolic diseases among adolescents are obesity, excessive food intake, socioeconomic status, breakfast habits, and physical activity, among others. Objective: This study aimed to determine the determinants of cardiometabolic risk in adolescents aged 15-18. Methods: This was a cross-sectional study in Al-Abidin High School Surakarta with 146 study subjects. Cardiometabolic risks were classified using Cardiometabolic Disease Staging (CMDS), waist circumference was measured with Medline, physical activity was measured using a Physical Activity Questionnaire for Adolescents (PAQA), and blood pressure was measured with a sphygmomanometer. Socioeconomic, transportation, and breakfast habits were obtained from the general questionnaire. Chi-square, ANOVA, and logistic regression were then performed using SPSS 23. Results: Gender was significantly associated with cardiometabolic risk (p=0.001). A total of 41.3% of boys were at risk of cardiometabolic (OR=3.964). Socioeconomic, breakfast habits, transportation, and physical activity were not associated with cardiometabolic risk (p>0.05).Conclusion: Boys 15 – 18 years were at a higher risk of cardiometabolic, by 3.694 times greater than girls. Socioeconomic status, breakfast habits, transportation, and physical activity were not correlated with cardiometabolic risk among adolescents.
Environmentally Responsible Behavior: The Roles of Personal Norms, Perceived Value, and Destination Social Responsibility
Authors: Ginting Ginta , Dewi Ike Janita , Maesaroh Imas 
Published: January 2025

Objective: The objective of the study is to analyze the factors that shape tourists' environmentally responsible behavior. The proposed research model integrates norm activation theory, stakeholder theory, and a utilitarian perspective. From the norm activation theory perspective, two variables, namely awareness of consequences and ascribed responsibility, are included in the model as antecedents of personal norms. Destination social responsibility, as a stakeholder effort to promote environmental protection, can strengthen the influence of personal norms on environmentally responsible behavior. Furthermore, the utilitarian perspective in the form of perceived value, which is the benefit that tourists obtain from traveling to a destination, is also a moderating influence of personal norms on environmentally responsible behavior. Methodology: This study involved 255 respondents who had visited Yogyakarta. Data were processed using Smart-PLS to determine the relationships between variables. Finding: The results show that awareness of consequences and ascribed responsibility are factors in forming personal norms. Personal norms have a positive influence on environmentally responsible behavior. Furthermore, the data supported the role of perceived value as a moderator. However, destination social responsibility does not moderate the influence of personal norms on environmentally responsible behavior. Conclusion: The study concludes that the norms activation theory holds that personal norms are antecedents to environmentally responsible behavior. Personal norms’s influence on environmentally responsible behavior is strengthened by perceived value.
Moderating of Inflation Policy and Its Relation to the Effect of Interest Rate and Exchange Rate on Decreasing IHSG
Authors: Subhan Nuruddin 
Published: January 2025

Objectives: The objectives of this research are: 1) to determine the effect of interest rates on the IHSG; 2) to determine the effect of the exchange rate on the IHSG; 3) to know the effect of the interest rate on the IHSG with inflation as moderation; and 4) knowing the effect of the exchange rate on the IHSG with inflation as moderation. Methodology: This research methodology was carried out using a quantitative model with a moderating effect analysis method which was processed using SmartPLS 3.0. The research findings and conclusions show that the significance value of interest rates is 0.747>0.05, which means that interest rates do not influence the IHSG. This means that interest rate movements during 2017-2022 are stable so that it does not cause investors to withdraw shares which has an impact on weakening the IHSG. Furthermore, the significance value of the exchange rate is 0.010<0.05, which means that there is an influence of the exchange rate on the IHSG. This is caused by the instability of the exchange rate in Indonesia during 2017-2022, because an increase in the exchange rate means that dividends distributed will decrease and investors will withdraw their shares, resulting in a weakening of the IHSG. Finding: The moderation of inflation on the effect of interest rates on the IHSG obtained a significance value of 0.000<0.05. Likewise, the moderation of inflation on the impact of the exchange rate on the IHSG obtained a significance value of 0.000<0.05. Conclusion: Inflation significantly moderates the influence of the interest rate and the exchange rate on the IHSG
Harmony of Nature: Building a Healthy Tourism Image Through Green Product Development
Authors: Setini Made , Putra Ida Bagus Udaya , Wahyuni Ni Made , Asih Daru , Triandini Evi 
Published: January 2025

Objectives: Nowadays, village progress has also become a benchmark for the success of development in a country and region. The orientation of this study is to analyze the condition and potential of Subaya Village, Bangli, Kintamani, by using a mixed approach that combines field observation and SWOT analysis. The methodology applied involves in-depth observation of the village's strengths and weaknesses, as well as interviews with village officials and communities to identify opportunities and threats.Methodology: Applied using Analytical Hierarchical Process analysis involves in-depth observation of village strengths and weaknesses, as well as interviews with village officials and communities to identify opportunities and threats (SWOT-AHP). The main focus explored is to collect information from the local community and village officials regarding the potential of Subaya Village. Finding: This study shows that Subaya Village has significant strengths, such as abundant natural resources and rich local culture, which can be utilized for tourism development. However, there are weaknesses in infrastructure and limited human resources that need to be overcome. This research also identifies opportunities to develop ecotourism and community empowerment programs. Threats faced, such as climate change and competition from other regions, require appropriate mitigation strategies. Conclusion: Expected to provide a basis for the sustainable development of Subaya Village and improve community welfare through optimal utilization of local potential, and the utilization of the regional potential of Subaya Village through the development of tourism and ecotourism programs can enhance the welfare of the community while overcoming existing weaknesses and threats
Pre-operative moderate cognitive impairments and their importance in cognitive dysfunction development in post-coronary bypass patients
Authors: Trubnikova O. A. , Tarasova I. V. , Syrova I. D. , Kukhareva I. N. , Maleva O. V. 
Published: January 2025

Aim. To determine the incidence and risk factors of postoperative cognitive dysfunction (POCD) after coronary bypass (CABG) in patients with pre-operative moderate cognitive impairment (MCI).Materials and Methods. Up to CABG two groups were formed, consisting of 50 patients with presence and 51 without MCI. Neuropsychological research (12 tests) was conducted up to CABG, on the 10th day and after 1 year. Early (10 days after surgery) and remote (1 year later) POCD were diagnosed with a 20 % decrease in the rate of 20% of tests.Results. Prior to CABG, they had a lower level of formation (p = 0.03), a lower fraction of the left ventricle ejection, (p = 0.02) and a more severe coronary tract lesion on the SYNTAX scale, (p = 0.01) than patients without MCI. Factors significant for the development of early POCD were the duration of with cardiopulmonary bypass (p = 0.035) and the severity of multi-organ insufficiency, rated on the SOFA scale (p = 0.04). In persons with pre-operative MCI, 72 % of cases were diagnosed with early POCD, 54 % with remote POCD, and 81 % with early POCD.Conclusion. Chronic heart failure with low rates of left ventricular ejection fraction, severe coronary artery damage and low levels of education contribute to the development of MCI in patients with ischemic heart disease. Pre-operational MCI is not the main cause of POCD. However, its presence and development in these patients of early POCD contributes to its retention a year after surgery.
Epidemiological characteristics of mental disorders in the population of the Omsk region. A descriptive study (2010−2022)
Authors: Shirlina N. G. , Shirinskaya N. V. , Zhigalov Y. A. , Stasenko V. L. 
Published: January 2025

Aim. Assessment of epidemiological manifestations of mental disorders in the Omsk region for the period 2010-2022.Materials and methods. A retrospective epidemiological analysis of data from the federal statistical observation form No. 10 «Information on diseases with mental disorders and behavioral disorders (except for diseases related to the use of psychoactive substances)» for the Omsk region for 2010−2022 was carried out. The incidence rates (relative prevalence) of mental disorders per 100,000 population were calculated for the Omsk region as a whole and municipalities, taking into account the distribution of cases among men and women, by age groups 0−19 years, 20−39 years, 40−59 years, 60 years and older, using relative values.Results. The incidence of mental disorders in the Omsk region was 3213.5 per 100 thousand people. Among both sexes, the incidence of PR in the region had a moderate downward trend (Tsn = 1.25 %; p < 0.001). There was a moderate downward trend (Tsn = 1.55 %; p < 0.001) in the incidence of psychoses and dementia among men. There were no trends in the female population and the territory of residence (Tsn. = 0.35 %; Tsn. = 1.07 % in urban areas, p < 0.001 and Tsn. = 0.8 % in rural areas, p < 0.001, respectively). In the younger (0−19 years old) and older (40−59 years old, 60 years old and older) age groups, mental disorders of a non-psychotic nature were in the lead in the structure of the incidence of PR, while mental retardation was a priority at the age of 20-39 years.Conclusion. The incidence of mental disorders in the Omsk region exceeded the national average (by 21.5 %). In dynamics, the trend towards a decrease in the incidence of mental disorders in the region was observed among both sexes, but was largely due to a decrease in this indicator in men. In the age structure of patients with mental disorders in the Omsk region, people aged 20−39 years were in the lead for 2010−2022. A moderate tendency to an increase in the incidence of PD was revealed in the age groups of 60 years and older throughout the region (Tpr. = 1.6 %; p < 0.001), as well as in people aged 40−59 years living in rural areas.
The influence of risk factors for cardiovascular diseases on the morphofunctional properties of mesenchymal stem cells
Authors: Slesareva T. A. , Uchasova E. G. , Dyleva Yu. A. , Belik E. V. , Gruzdeva O. V. 
Published: January 2025

Today, the contribution of mesenchymal stem cells (MSCs) to the mechanism of development of pathologies such as calcification of heart valves and blood vessels is being actively discussed. This is due to the fact that the formation of calcifications in the cardiovascular system (CVS) repeats the process of ossification, that is, it is mediated by specific bone cells - osteocytes. Since MSCs are progenitor cells capable of multilineage differentiation, they are considered as a source of osteocytes in the cardiovascular system. The question of what stimuli activate the osteogenesis program in MSCs localized in the CVS organs remains open. The presence of risk factors for cardiovascular diseases (CVD) has a systemic effect on the body, as it contributes to the development of pathological processes such as hypoxia and inflammation, which lead to remodeling of the MSC niche and changes in their function. This review systematizes scientific studies devoted to the influence of modifiable and non-modifiable CVD risk factors on the morphofunctional properties of MSCs.The purpose of this review is to systematize existing knowledge about the role of modifiable and non-modifiable CVD risk factors in changing the morphology and function of MSCs.The functioning of MSCs depends on the age of the donor and the duration of their cultivation in vitro, due to the activation of cellular aging processes. The influence of gender on MSCs is controversially described in the literature; however, there is evidence of the participation of estrogen in regulating the balance between osteogenic and adipogenic differentiation of progenitor cells. The presence of comorbid conditions such as hypercholesterolemia, obesity, and diabetes mellitus contribute to the acceleration of cellular aging, modification of the MSC phenotype, and influence the activity of their proliferation and differentiation potential. Thus, the complex of pathological processes accompanying obesity and diabetes mellitus leads to a decrease in the differentiated potential of MSCs, and also induces the expression of genes that are markers of cellular aging. An increase in the concentration of cholesterol esters in the microenvironment of MSCs induces a program of osteogenic differentiation in them, and exposure to high density lipoproteins (HDL) has a positive effect on proliferation. Cigarette smoke activates stem cell apoptosis, reduces proliferation, and induces osteogenesis.
Respon Keterlaksanaan E-Book Ilmu Lingkungan Berorientasi Conceptual Change
Authors: Febrianti Yuli , Endang Suswati  , Nopa Nopiyanti  
Published: January 2025

Tujuan dalam penelitian ini adalah menganalisis keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change. Penelitian ini merupakan penelitian deskriptif kualitatif melalui lembar keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change. Teknik pengumpulan data dengan menggunakan kuesioner (angket) berbentuk kuesioner tertutup yang berisikan tentang aspek pengamatan yang diberikan kepada pengamat untuk mengetahui sejauh mana keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change yang dibuat oleh peneliti. Adapun teknik analisis data digunakan untuk menganalisis data yang diperoleh melalui kuesioner (angket) yang telah dinilai oleh pengamat. Analisis data yang digunakan dengan cara mengelompokkan informasi dari data hasil kualitatif yang berupa tanggapan dan hal-hal lain yang ditemukan selama pengamatan. Adapun analisis data dijadikan acuan untuk memperbaiki atau merefisi produk. Data yang diperoleh dianalisis dan diukur persentase respon pengamat melalui pedoman skor penilaian respon pengamat terhadap keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change. Hasil penelitian ini adalah perolehan skor angket yang disi oleh pengamat diperoleh jumlah skor angket 38 dan dihitung menggunakan rumus diperoleh hasil yaitu 95%. Simpulan dalam penelitian ini adalah respon yang positif dari pengamat terhadap keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change sehingga layak digunakan sebagai sumber belajar mandiri.
Kata Kunci—Conceptual Change, E-Book, Ilmu Lingkungan, Kuesioner (Angket), Respon Keterlaksanaan.
Pengaruh Pembelajaran Biologi Berbasis Proyek pada Kurikulum Merdeka terhadap Kemampuan Berpikir Kritis di SMA Muhammadiyah Langsa
Authors: Listya Dinda , Sarjani Tri Mustika , Ariska Raja Novi 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh pembelajaran biologi berbasis proyek pada kurikulum merdeka terhadap kemampuan berpikir kritis di SMA Muhammadiyah Langsa. Penelitian ini menggunakan jenis penelitian eksperimen dengan pendekatan kuantitatif. Desain yang digunakan dalam penelitian ini adalah one group pretest-posttest design. Sampel penelitian ini adalah siswa/siswi kelas X1 (Eksperimen) dan X2 (Kontrol) SMA Muhammadiyah Langsa dengan jumlah 33 siswa. Hasil penelitian meinunjukkan bahwa nilai rata-rata preiteist keilas eikspeirimein seibeisar 41,5 dan keilas kontrol seibeisar 30,65. Seidangkan nilai rata-rata postteist keilas eikspeirimein seibeisar 74,80 dan keilas kontrol seibeisar 51,15. Data dianalisis meinggunakan uji t-teist Polleid Varian. Beirdasarkan uji hipoteisis nilai postteist seibeisar 5,21 deingan taraf signifikan α = 0,05 maka dipeiroleih ftabeil = 2,04 deingan keiteintuan fhitung > ftabeil , 5,21 > 2,04 maka Ho ditolak dan Ha diteirima seihingga dapat disimpulkan teirdapat peingaruh dalam meinggunakan modeil peimbeilajaran beirbasis proyeik teirhadap keimampuan beirpikir kritis siswa di SMA Muhammadiyah Langsa. Dan rata-rata untuk peinilaian karya dari siswa seibeisar 73,43.
Bioprospecting Test of Piper betle Leaf Essential Oil Against Staphylococcus Aureus and Escherichia Coli-Antibiotic Resistant
Authors: Anindita Reza , Beandrade Maya Uzia , Putri Intan Kurnia 
Published: January 2025

One of the efforts to overcome antibiotic resistance is the bioprospection of natural materials that have the potential to be antibacterial. One of the results of distilling natural materials with antibacterial potential is betel leaf essential oil (Piper betle). This study aimed to determine the effect of essential oils on Staphylococcus aureus and Escherichia coli-resistant antibiotics. The design of this study is experimental, with independent variables in the form of essential oils with concentrations of 5%, 10%, 15%, 20%, 25%, and 100%. In contrast, the dependent variable is the diameter of the growth inhibition zone of S. aureus and E.coli bacteria. Essential oil extraction using steam distillation and chemical characterization by GC-MS test. Antibacterial testing uses the Kirb-Bauer method. GC-MS test results were dominant eugenol (3.50%), caryophyllene (3.79%), and Germacrene D (1.19%). The application of essential oils was able to inhibit the growth of S. aureus with inhibition zone diameters of 10.5 mm (moderate), 10.6 mm (moderate), 10.8 mm (moderate), 12.3 mm (strong), 14 mm (strong), and 30.2 mm (very strong), while E. coli was 5.7 mm (moderate), 7.5 mm (moderate), 10.5 mm (moderate), 12 mm (strong), and 30.03 mm (very strong). The results of the ANOVA one-way test showed a value of 11762.7, while the F table was 3.48 (Fcal > Table). This study concludes that administering essential oils with concentrations of 5%, 10%, 15%, 20%, 25%, and 100% can significantly inhibit the growth of S. aureus and E.coli bacteria.