bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant-food-derived Bioactives in Managing Hypertension: From Current
Findings to Upcoming Effective Pharmacotherapies
Authors: Butnariu Monica , Fratantonio Deborah , Herrera-Bravo Jesús , Sukreet Sonal , Martorell Miquel , Ekaterina Robertovna Garsiya , Les Francisco , López Víctor , Kumar Manoj , Pentea Marius , Sarac Ioan , Becherescu Alexandra , Cruz-Martins Natália , Setzer William N. , Iriti Marcello , Rasul Suleria Hafiz Ansar , Sharifi-Rad Javad 
Published: January 2023

Abstract:
A sedentary lifestyle has evoked a high risk of cardiovascular (CV) disease, diabetes, and obesity, all of them with high morbimortality rates and with a common denominator, hypertension. Numerous pharmacological drugs have been used for the treatment of hypertension. However, the side effects associated with the use of existing pharmacological therapies have triggered a demand for plant-based medications. In this connection, the aim of this review was to provide an in-depth analysis of the use of plant-derived bioactives for the effective management of hypertension. Phyto-constituents from leaves, bark, stem, roots, seeds, and fruits of medicinal plants grown in our differ-ent regions of the globe have been highly searched. Among them, polyphenols (e.g., flavonoids as quercetin, anthocyanins as cyanidin, tannins as ellagic acid, stilbenes as resveratrol, lignans as honokiol and others as hydroxytyrosol or curcumin), organosulfur compounds (e.g. s-allyl cysteine and allicin), fatty acids (e.g. α-lipoic acid, DHA and oleic acid), alkaloids (e.g. berberine or tetran-drine) and some terpenes have been intensively investigated for the management of hypertension, with effective ability being stated in controlling high blood pressure and related health problems both in vivo and in vitro studies. Some of the activities presented by these bioactive compounds are reducing oxidative stress, renin-angiotensin system control, SIRT1 activation, regulating platelet aggregation and COX activity, anti-atherogenic effects, anti-inflammatory properties, vasorelaxa-tion and other results that translate into the prevention or control of hypertension. The knowledge of these bioactive compounds is important in developing countries where traditional medicine is the majority, but it can also give rise to new approaches in hypertension therapy.
Evaluación de los gases de combustión y material particulado en el aire de parqueaderos del Distrito Metropolitano de Quito, Ecuador
Authors: López Terán Jorge Luis , Correa Abril Jhonny , Cano Yulixis , Bermúdez Portero José 
Published: January 2023

La emisión de gases vehiculares y de material particulado en el aire de las ciudades afectan la calidad del aire y la salud de las personas, situación ligada a las actividades antropogénicas como el transporte vehicular, la actividad industrial y el microclima de cada ciudad. En tal sentido, se determinó la cantidad de gases de combustión y el material particulado producido por automóviles que llegan a dos parqueaderos del Distrito Metropolitano de Quito (DMQ). La recolección de muestras fue realizada empleando un analizador de gases móvil T. El estudio se realizó durante 21 días del año 2017 en dos parqueaderos de automóviles ubicados en el mercado Comité del Pueblo (Sector Centro) y en el mercado San Francisco (Sector Norte) de la ciudad de Quito (Total= 42 días). Los resultados indican que el sector centro presentó valores elevados de los gases SO2, NOx y O3, mientras que en el sector norte se observaron valores altos en NO2, CO2, O3 y CO. Las concentraciones de Ozono (O3), resultaron elevadas en el Sector Centro (112,07 µg/m3), muy cerca del límite máximo permisible establecido, así como las de NOx también se encuentra cerca del límite máximo permisible por la OMS (400 µg/m3). Los datos revelan que a pesar de tener valores significativos de concentración bastante cercanos entre los dos sectores para ciertos gases como el NOx y NO2, también existen grandes diferencias entre los valores obtenidos para O3, CO y NO2. Con relación al material particulado, los valores en ambos sitios fueron similares, observando valores elevados para PM2,5.
Evaluation of Two Web-Based Interventions (Res-Up! and REMOTION) in Routine Outpatient Psychotherapy (Therapy Online Plus—TOP): Protocol for a Randomized Controlled Trial
Authors: Trimpop Leonie Franziska , Bielinski Laura Luisa , Berger Thomas , Willutzki Ulrike 
Published: January 2023

Background
Only 11%-40% of those with a mental disorder in Germany receive treatment. In many cases, face-to-face psychotherapy is not available because of limited resources, such as an insufficient number of therapists in the area. New approaches to improve the German health care system are needed to counter chronification. Web-based interventions have been shown to be effective as stand-alone and add-on treatments to routine practice. Interventions designed for a wide range of mental disorders such as transdiagnostic interventions are needed to make treatment for mental disorders more accessible and thus shorten waiting times and mitigate the chronification of mental health problems. In general, interventions can be differentiated as having either a capitalization (CAP) focus—thus drawing on already existing strengths—or a compensation (COMP) focus—trying to compensate for deficits. Up to now, the effectiveness of transdiagnostic web-based interventions with either a CAP or a COMP focus has not yet been evaluated.

Objective
This study is the first to examine the effectiveness of two transdiagnostic web-based interventions: (1) the activation of resilience and drawing on existing strengths (CAP: Res-Up!) and (2) the improvement of emotion regulation (COMP: REMOTION), compared with care as usual (CAU) in routine outpatient psychotherapy.

Methods
Adults with at least 1 mental health disorder will be recruited at 4 outpatient centers in Germany. Participants will then be randomized equally into 1 of the 2 intervention groups Res-Up! (CAP) and REMOTION (COMP) or into the control group (CAU). Assessments will be made at baseline (T0), at 6 weeks after treatment start (T1), and at 12 weeks after treatment start (T2). A primary outcome will be symptom severity (Brief Symptom Inventory-18). Secondary outcomes will focus on emotion regulation and resilience.

Results
Participant recruitment and data collection started in April 2020 and were ongoing as of July 2022. We expect participants to benefit more from the interventions than from the CAU control on the dimensions of symptom severity, resilience, and emotion regulation. Furthermore, we expect to find possible differences between CAP and COMP. The results of the study are expected in 2023.

Conclusions
This randomized controlled trial will compare CAU with the transdiagnostic web-based interventions Res-Up! and REMOTION, and will thus inform future studies concerning the effectiveness of transdiagnostic web-based interventions in routine outpatient psychotherapy.

Trial Registration
ClinicalTrials.gov NCT04352010; https://clinicaltrials.gov/ct2/show/NCT04352010

International Registered Report Identifier (IRRID)
DERR1-10.2196/41413
Dampak Erosi Terhadap Kehilangan Hara Makro Pada Lahan Agroforestry Kopi Dan Kayu Manis Di Kecamatan Siulak Kabupaten Kerinci
Authors: Wahyu Pratama Zefa , Syarif M. , Junedi Heri 
Published: January 2023

Kabupaten Kerinci terletak pada posisi 01°40’ dan 02°26’ Lintang Selatan, serta 101°08’ sampai
dengan 101°50’ Bujur Timur. Wilayah Provinsi Jambi sepenuhnya berada di selatan garis
2 khatulistiwa. Luas wilayah Kabupaten Kerinci adalah 332.814 Ha atau 3328,14 km . Tanah di
Kecamatan siulak memiliki unsur hara yang rendah serta pH berkisar (4,6-5,18). Kondisi tanah dengan unsur hara yang rendah dalam tanah yang mengakibatkan terhambatnya pertumbuhan tanaman. Penelitian ini bertujuan untuk mengetahui kehilangan hara makro akibat tererosi pada lahan agroforestry kopi dan kayu manis. Penelitian ini telah dilaksanakan di Kecamatan Siulak, Kabupaten Kerinci dengan metode pengukuran langsung di lapangan. Penentuan lokasi penelitian dilakukan secara purposive sampling. Metode analisis yang digunakan adalah metode C-organik (Kurmis), N Total (Kjeldhal), P-tersedia (Bray I), dan K-dd (NH4OAc pH 7.0 1N). Hasil Penelitian menunjukkan3 -1 erosidanaliranpermukaansertakehilanganharasebesaraliranpermukaan10,71m ha ,erosi0,987
3 -1 ton ha−1, pada lahan P1 lebih besar dari lahan P2 dengan aliran permukaan 1,32 m ha , erosi 0,011
-1 -1 -1 ton ha−1. Jumlah kehilangan, N 4,83 g l , P 0,82 g l , dan K 0,0723 g l , pada lahan P1 lebih tinggi
-1 -1 -1 darilahanP2dengan(N0,82gl ,P0,00042gl ,danK0,00240gl ).
Validating the TeenHITSS to Assess Child Abuse in Adolescent Populations
Authors: Day Philip G. , Woods Sarah B. , Gonzalez Leo , Fernandez-Criado Rodolfo , Shakil Amer 
Published: January 2023

Purpose: The purpose of this study is to establish the psychometric properties and diagnostic accuracy of the Teen Hurt-Insult-Threaten-Scream-Sex (TeenHITSS), a 5-item measure used to screen adolescents for family violence in clinical settings.
Methods: Study participants included 251 adolescent participants (n=197 not at-risk subsample; n=56 at-risk subsample), recruited from ambulatory care clinics, a medical center at-risk referral clinic, and area shelters. Participants completed a cross-sectional survey, including the TeenHITSS and Parent-Child Conflict Tactics Scales (CTSPC) questionnaires. We calculated internal reliability, validity, and sensitivity and specificity for the full sample and both subsamples for each screening instrument.
Results: Concurrent validity between the TeenHITSS and CTSPC was strong (r=.71, P&lt;.000). We determined an optimal cutpoint based on sensitivity and specificity for correctly identifying abuse victims as a score of one or greater on the TeenHITSS. The TeenHITSS also proved slightly superior to the CTSPC in differentiating between victims and nonvictims of adolescent abuse (AUC=.79 vs .73, respectively).
Conclusions: The TeenHITSS screening tool performed as well as the CTSPC in correctly classifying at-risk and not-at-risk teenagers and offers much greater utility to providers by supplying an actionable cut score. The findings of this study suggest that TeenHITSS is a valid and reliable tool to screen for physical and sexual abuse in children ages 13 years and older in clinical settings and can help health care providers detect adolescent abuse and initiate intervention and prevention of future abuse.
Severe COVID-19 Infection in Type 1 and Type 2 Diabetes During the First Three Waves in Sweden
Authors: Edqvist Jon , Lundberg Christina , Andreasson Karin , Björck Lena , Dikaiou Pigi , Ludvigsson Johnny , Lind Marcus , Adiels Martin , Rosengren Annika 
Published: January 2023

OBJECTIVEType 2 diabetes is an established risk factor for hospitalization and death in COVID-19 infection, while findings with respect to type 1 diabetes have been diverging.RESEARCH DESIGN AND METHODSUsing nationwide health registries, we identified all patients aged ≥18 years with type 1 and type 2 diabetes in Sweden. Odds ratios (ORs) describe the general and age-specific risk of being hospitalized, need for intensive care, or dying, adjusted for age, socioeconomic factors, and coexisting conditions, compared with individuals without diabetes. Machine learning models were used to find predictors of outcomes among individuals with diabetes positive for COVID-19.RESULTSUntil 30 June 2021, we identified 365 (0.71%) and 11,684 (2.31%) hospitalizations in 51,402 and 504,337 patients with type 1 and 2 diabetes, respectively, with 67 (0.13%) and 2,848 (0.56%) requiring intensive care unit (ICU) care and 68 (0.13%) and 4,020 (0.80%) dying (vs 7,824,181 individuals without diabetes [41,810 hospitalizations (0.53%), 8,753 (0.11%) needing ICU care, and 10,160 (0.13%) deaths). Although those with type 1 diabetes had moderately raised odds of being hospitalized (multiple-adjusted OR 1.38 [95% CI 1.24–1.53]), there was no independent effect on ICU care or death (OR of 1.21 [95% CI 0.94–1.52] and 1.13 [95% CI 0.88–1.48], respectively). Age and socioeconomic factors were the dominating features for predicting hospitalization and death in both types of diabetes.CONCLUSIONSType 2 diabetes was associated with increased odds for all outcomes, whereas patients with type 1 diabetes had moderately increased odds of hospitalization but not ICU care and death.
Perspectives on Rent Generation and Rent Appropriation in Fisheries
Authors: Bertheussen Bernt Arne 
Published: January 2023

The article debates the origin of rent in natural-resource based industries (NRBIs) such as fisheries, and how the rent generated can be appro­priated. The Norwegian fish harvest­ing industry is used to illustrate the arguments. It is argued that the industry-specific institu­tional framework of the fish harvesting industry positively affects the compe­titive forces of the industry, and thereby its economic performance. Fishery management institu­tions create high barriers to entry for outside firms, and they dampen internal rivalry between incumbent firms. As a result, the opportunity to earn what this paper labels institutional rent arises. The article further argues that nature itself and how it is managed through, for example, harvesting rules, enables an NRBI to earn resource rent if the players get free or cheap access to the input factor, in this case fish. Finally, the article argues that it is stakeholders other than the harvesting companies that control both the institutional and resource rents, that is, the owners of the natural resource and the authorities who manage it as well as the industry-specific institu­tional framework. Nevertheless, neither the owners nor the authorities benefit from the industry-specific rent generated. The rent is appropriated by the capital owners and the crew onboard the boats in the form of above-normal profits and above-normal wages. Whether or not such a skewed rent distribution is considered fair and sustainable is a political issue.
ANALISIS KEPEMIMPINAN PENDIDIKAN DI INDONESIA DAN CHINA DALAM UPAYA PENINGKATAN MUTU PENDIDIKAN
Authors: Endaryati Sri Adhi , Marmoah Sri 
Published: January 2023

Principals of Elementary Schools have an effect on improving the quality of education. This research is a descriptive qualitative research. The aim of this research is to describe the leadership of elementary schools in Indonesia and China. Data and data sources are taken from interviews and questionnaires. Sources of literature review data in the form of journals, books, and articles are more effective. Qualitative research methods to enrich information data in depth about the problem to be solved. Data collection techniques with questionnaires, interviews, and literature review. The research data analysis technique is an interactive model of Miles and Huberman which begins with collecting raw data, displaying data, reducing data, verifying data, and concluding data. The results showed that the principal’s leadership influenced the improvement of the education quality of school institutions. Primary school leadership in Indonesia and China share a common commitment to realizing the vision and mission for the advancement of school quality, communicating with teachers about the vision and mission to be achieved, empowering the work climate for teachers professional performance. The difference between principal’s leadership in Indonesia and China lies in the dedication of working time in China is longer than the working time of principals in Indonesia. Indonesia with democratic leadership while China with instructional leadership It is hoped that school principals can improve performance and leadership quality for the advancement of education in Indonesia so as to produce quality and competitive output in 21st century life.
PENGEMBANGAN PERANGKAT PEMBELAJARAN BERBASIS DIGITAL DENGAN APLIKASI ARTICULATE STORYLINE UNTUK MELATIH LITERASI SAINS
Authors: Melani Witri Saidini Mukti , Mukti Rahayu Hanum , Sunandar Ari 
Published: January 2023

Penelitian ini bertujuan mengembangkan perangkat pembelajaran berbasis digital untuk melatih literasi sains. Metode yang digunakan yaitu metode pengembangan Research and Development Sugiono yang terdiri atas 10 tahap namun, pada penelitian ini hanya dilakukan sampai 7 tahap saja yaitu, identifikasi masalah, pengumpulan data, desain perangkat pembelajaran,validasi desain, revisi perangkat, uji coba produk, dan revisi perangkat pembelajaran. Namun uji coba pemakaian, revisi produk, dan produksi masal tidak dilakukan. Hasil penelitian interpretasi kevalidan menunjukkan produk pengembangan perangkat pembelajaran yang dikembangkan terdiri dari aspek bahasa dan aspek media dengan interprestasi 75% valid, dan pada aspek materi 85% dapat dikatakan sangat valid, sedangkan uji kepraktisan diperoleh nilai rata-rata 77% dengan interprestasi valid. Interprestasi hasil respon peserta didik dapat kategori baik dengan nilai 63% sehingga perangkat pembelajaran dikatakan layak untuk digunakan oleh pendidik dan peserta didik dalam proses pembelajaran.

Kata Kunci : Literasi Sains, Perangkat Pembelajaran, Research and Development.
Analisis Politisasi Identitas dalam Kontestasi Politik pada Pemilihan Umum di Indonesia
Authors: M.Si Frenki 
Published: January 2023

Penelitian ini bertujuan untuk menganalisis politisasi identitas dalam kompetisi pada pemilu di Indonesia. Politisasi identitas tersebut berupa mempolitisir simbol-simbol agama dan etnis sebagai alat politiknya. Penelitian ini merupakan penelitian kualitatif, bersifat deskriptif analisi, dari sumber data primer dan sekunder, data dikumpulkan mengunakan riset kepustakaan (library research), data dilolah melalui editing, coding, dan sistematizing, kemudian dianalisis menggunakan analisis kualitatif dengan cara berfikir deduktif. Adapun hasil dari penilitian ini adalah bahwa para kandidat yang ikut serta dalam kontestansi politik pada pemilu berkemungkinan menang manakalah memiliki tiga modal utama yaitu modal sosial, modal politik dan modal ekonomi. Namun, modal sosial yang dimiliki tersebut banyak disalahgunakan untuk menjatuhkan lawan politiknya. Politisasi identitas agama dan etnis minoritas dianggap efektif bagi para kandidat untuk memperoleh dukungan dari masyarakat beragama dan etnis mayoritas. Praktik politisasi identitas senantiasa muncul pada tahun politik, baik itu pada tingkat pemilihan kepala daerah bahkan pemilihan presiden. Permasalahan praktik politisasi identitas pada pemilu di Indonesia patut dicermati, karena praktik tersebut berpotensi mengarah pada dampak yang berlawanan dengan tujuan demokrasi dan menjurus pada perpecahan yang menyebabkan terjadinya instabilitas politik dan disintegrasi bangsa Indonesia. Untuk itu, para kandidat yang terlibat dalam kontesrtasi pilitik pada pemilu hendaknya memiliki kesadaran yang tinggi dan lebih mengutamakan persatuan dan kesatuan bangsa dari daripada kepentingan politik sesaat.
Partial ceratohyoidectomy as surgical treatment for horses with temporohyoid osteoarthropathy: 10 cases (2010–2021)
Authors: Booth Alyson D. , Hidalgo Felipe Lara , Bellezzo Fausto , Young Jenna M. , Bianco Alex W. , Hughes Lauren E. , Maher Mike , Trumble Troy N. , Ernst Nicolas 
Published: January 2023

Abstract

OBJECTIVE
To describe outcomes of horses with temporohyoid osteoarthropathy (THO) treated with partial ceratohyoidectomy.

ANIMALS
10 client-owned horses

PROCEDURES
Medical records from 2 institutions were examined for records of horses with THO treated with partial ceratohyoidectomy between 2010 and 2021. History, signalment, clinical signs, diagnostics, medications, and surgery-related details were recorded. Horses with a minimum of 6 months follow-up were recruited for neurologic and imaging examinations in the hospital or field where radiography of the basihyoid-ceratohyoid articulation were performed along with CT, when available.

RESULTS
10 horses with THO were included (9 unilateral; 1 bilateral). Nine planned partial ceratohyoidectomies were performed in 8 horses, whereas 2 horses had preoperatively planned complete ceratohyoidectomies transitioned to partial ceratohyoidectomies during surgery due to intraoperative complications. Postoperative complications occurred mostly in transitioned surgeries (obstructed airway, tongue mobility issues, and incisional hemorrhage), whereas only 1 horse with a planned ceratohyoidectomy had postoperative complication of rhabdomyolysis. All complications resolved before hospital discharge. Neurologic signs improved in all 10 horses, with 2 showing complete resolution. Nine horses were available for radiographic follow-up, 6 of which also had head CT scans. A space between the ceratohyoid and basihyoid bones was measurable on radiography in all 9 horses, and was confirmed on CT. Three horses demonstrated proliferation of either ceratohyoid or basihyoid bones. The 9 horses with unilateral disease returned to previous work, and the horse with bilateral disease was retired.

CLINICAL RELEVANCE
Partial ceratohyoidectomy is a surgical option for treatment of THO that provides similar clinical outcomes to published reports on ceratohyoidectomy.
The role of selenium in nutrition and the manufacturing of selenium-enriched milk
Authors: Tóth R. Juhászné , Kiss D. , Csapó J. 
Published: January 2023

Abstract
The role of selenium has increased after the discovery of the first seleno-enzyme in the human body. Selenium supports growth, the immune system, the reproductive organs, thyroid and muscle function, has an antioxidant effect, and protects against free radicals. The recommended daily intake of selenium for adults is 55 µg/day, which cannot be covered with food alone in selenium-deficient areas. That is the reason why we chose as our research topic the production of functional food – in this research: milk – in which the selenium level has been elevated naturally.
In our work, we supplemented six Holstein-Friesian cattle feeds with a daily 1, 2, 4, and 6 mg/individual organic selenium, and then we measured the selenium content by ICP-MS. With a selenium enrichment of 1 mg/day, a 60% increase in selenium content was achieved, as the selenium content of milk increased from 32.93 µg/kg to 52.79 µg/kg. With the 2, 4, and 6 mg supplementation, the milk contained 97.2, 182.69, and 231.31 µg/kg selenium respectively. The latter is seven times more than the selenium content of the control sample. We have developed a recommendation for the amount of naturally selenized milk that should be consumed for different age groups. In our opinion, milk with increased selenium content could contribute to improving the selenium status of the population.
Control of Remote Robots by Means of Cell Phones
Authors: Zaatri Abdelouahab , Kelaiaia Ridha 
Published: January 2023

Abstract
Since about two decades, cellular phones coupled to internet and wireless communications are offering many possibilities that can be exploited by classical telerobotics to free human operators from many constraints providing mobility and ubiquitous applications.
This paper presents the design and implementation of an experimental telerobotics system where the human operator supervises and controls remote robots by means of cell phones. To achieve this application, we used Java software namely J2ME platform which is dedicated for programming cell phones and J2SE platform for programming PCs. The adopted software technology of connection between the human operator and the remote robots uses the socket technique with client-server model. The cell phone held by the operator acts as a Client while a PC, situated at the remote robot site, acts as a Server. This application corresponds to Midlet-to-Servlet in Java terminology. Basic simulations and preliminary experiments have been successfully carried out with a three Degrees-of-Freedom (D.O.F) serial robot. These telerobotics systems based on cell phones are effectively offering interesting means to opening new perspectives for mobile and ubiquitous applications.