bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution
Authors: Sunagawa Junya , Kim Kwang Su , Park Hyeongki , Komorizono Ryo , Choi Sooyoun , Torres Lucia Ramirez , Woo Joohyeon , Jeong Yong Dam , Hart William S , Thompson Robin N. , Aihara Kazuyuki , Iwami Shingo , Yamaguchi Ryo 
Published: February 2023

AbstractDuring the COVID-19 pandemic, human behavior change as a result of nonpharmaceutical interventions such as isolation may have induced directional selection for viral evolution. By combining previously published empirical clinical data analysis and multi-level mathematical modeling, we found that the SARS-CoV-2 variants selected for as the virus evolved from the pre-Alpha to the Delta variant had earlier and higher infectious periods but a shorter duration of infection. Selection for increased transmissibility shapes the viral load dynamics, and the isolation measure is likely to be a driver of these evolutionary transitions. In addition, we showed that a decreased incubation period and an increased proportion of asymptomatic infection were also positively selected for as SARS-CoV-2 mutated to the extent that people did not isolate. We demonstrated that the Omicron variants evolved in these ways to adapt to human behavior. The quantitative information and predictions we present here can guide future responses in the potential arms race between pandemic interventions and viral evolution.
Cytosolic retention of the mitochondrial protease HtrA2 during mitochondrial protein import stress (MPIS) triggers the DELE1-HRI pathway
Authors: Bi Paul Y. , Killackey Samuel A. , Schweizer Linus , Arnoult Damien , Philpott Dana J. , Girardin Stephen E. 
Published: February 2023

ABSTRACTMitochondrial stress inducers, such as the proton ionophore carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and the ATPase pump inhibitor oligomycin, trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged forms of DELE1 showed that these stresses induced the accumulation of a cleaved form of DELE1, DELE1-S, which stimulates HRI. Here, we report that mitochondrial protein import stress (MPIS) is an overarching stress that triggers the DELE1-HRI pathway, and that endogenous DELE1 could be cleaved into two forms, DELE1-S and DELE1-VS, the latter accumulating only upon non- depolarizing MPIS. We further showed that DELE1 specifically senses MPIS triggered by the inhibition of the TIM23 complex at the inner mitochondrial membrane (IMM). While MPIS can also cause mitophagy induction through engagement of the NLRX1-RRBP1 pathway, we observed that DELE1-HRI and NLRX1-RRBP1 signaling were engaged independently upon MPIS. Surprisingly, our results suggest that in our cellular model the mitochondrial protease OMA1 was dispensable for DELE1 cleavage upon MPIS. Instead, we identified a key role for another mitochondrial protease, HtrA2, in mediating the cleavage of DELE1 into DELE1-S and DELE1- VS. Our data further suggest that DELE1 is likely cleaved into DELE1-S by HtrA2 in the cytosol, while the DELE1-VS form might be generated during halted translocation of the protein into mitochondria. Together, this study identifies MPIS as the overarching stress detected by DELE1 and identifies HtrA2 as a critical protease involved in DELE1 processing.
A discursive exploration of gender in primary textbooks of English in Pakistan
Authors: Dar Shazia Riaz , Bano Sobia 
Published: February 2023

PurposeThis study intends to unveil the imbalance in gender portrayal, reflected in English textbooks, used at the primary level in the four provinces of Pakistan.Design/methodology/approachWithin the framework of feminist critical discourse analysis (FCDA), this paper aims to explore the ways in which gender stereotypes and ideologies are inculcated through the discursive schemes in the selected textbooks. The methodology adopted is to connect the linguistic features in the texts (the Micro) to the social factors (the Macro). The analysis has been done on two levels: on the first level, the content analysis was employed to quantify the gender representation in the textbook. On the second level, the discourse analysis was carried out to view gender stereotypes in the wide spectrum of social norms.FindingsThe results of this study reveal a significant disproportion and imbalance in gender representation in the four books. They clearly show that the textbooks in Pakistan contribute to the socialization of children in a very traditional and stereotypical way. The findings of the study recommend extensive awareness at societal level in general, and particular reforms in the education sector for a step toward a progressive and prosperous society.Originality/valueThe current paper is innovative as it demystifies how gendered ideologies are ingrained in the curriculum, used for English language teaching in a developing country like Pakistan. It fosters the value addition in existing research since it investigated the gender disparity systematically by employing quantitative content and qualitative FCDA.
Do all brand CSR initiatives make consumers happy? The role of CSR-brand (mis)fit and sense of relatedness
Authors: Gilal Faheem Gul , Gilal Naeem Gul , Martinez Luis F. , Gilal Rukhsana Gul 
Published: February 2023

Purpose
This paper aims to explore whether brand corporate social responsibility (CSR) initiatives increase consumers’ happiness via a mediating mechanism of emotional brand attachment and to examine how brand CSR’s effect may be moderated by CSR fit (e.g. CSR-brand fit vs misfit) and sense of relatedness (e.g. low vs high).

Design/methodology/approach
A series of six studies (including the one that is available online), combining field and experimental data, were conducted to test the hypothesized relationships.

Findings
Results support the hypothesis that brand CSR initiatives make consumers happy by increasing their attachment to the brand (Studies 1 and 2). This effect is strengthened both directly and indirectly through emotional attachment when brands engage in CSR fit activities (Study 3), but it is weakened when brands engage in CSR misfit activities (Study 4). Furthermore, the effect is more pronounced when brands choose CSR activities that have a high sense of relatedness, and it is eliminated when brands use CSR activities with a low sense of relatedness (Study 5). Finally, the results indicate that when brand CSR programs make consumers happy, they become more likely to purchase, spread positive word of mouth and pay a premium (Study 6).

Originality/value
This research has several major implications for business-to-consumer companies that are unsure about the value of brand CSR initiatives, want to make consumers happy but are unsure which CSR strategies to focus on and/or have decided to launch CSR initiatives but lack guidance on the specific strategies relevant to their desired performance outcomes.
Competition–banking stability: the moderating role of government intervention quality in North African countries
Authors: Basty Nadia , Ghazouani Ines 
Published: February 2023

PurposeThis study investigates how bank competition affects financial stability and whether government intervention contributes to shaping this relationship in North African countries.Design/methodology/approachA review of the literature on the subject was conducted, combined with an empirical analysis that used a two-step system generalized method of moments (GMM) and a sample of 45 banks operating in North African countries over the period 2005–2019.FindingsThe findings reveal a quadratic relationship between competition and banking stability in North African countries. Competition–stability view and competition–fragility view could be applied at the same time for North African banks. Additionally, in this context, results highlight a negative impact of government intervention on financial stability in a competitive financial sector. North African banks operating in a high government intervention quality environment tend to engage in high-risk investments. Robustness checks with alternative measures of competition and banking stability also show consistent results.Originality/valueTo the authors’ knowledge, this is the first time that the North African context has been explored to determine the role of the quality of government intervention in the relationship between competition and banking system fragility. This paper seeks to cover the shadow field in existing literature through further new information. Thus, it contributes to the emerging market banking literature by showing that both high and low levels of competition can improve financial stability in North African countries. Moreover, it expands its contribution by displaying the moderator effect of intervention quality on the bank competition–stability relationship.
Interrogating the environmental accountability of foreign oil and gas companies in Basra, Iraq: a stakeholder theory perspective
Authors: Morrison Leanne J. , Alshamari Alia , Finau Glenn 
Published: February 2023

PurposeThis paper aims to interrogate the accountabilities of the foreign companies which have directly invested in the Iraqi oil and gas industry.Design/methodology/approachUsing both qualitative and quantitative methodologies, the authors first map the stakeholder accountabilities (qualitative) of foreign oil and gas companies and second, the authors seek to demonstrate quantitatively – through structural break tests and publicly available sustainability reports – whether these companies have accounted for their environmental and social impacts both to Iraqi people and to the global community.FindingsThe authors find that the Western democratic values embedded in stakeholder theory, in terms of sustainability, do not hold the same meaning in cultural contexts where conceptions and application of Western democratic values are deeply problematic. This paper identifies a crucial problem in the global oil supply chain and problematises the application of traditional theoretical approaches in the context of the Iraqi oil and gas industry.Practical implicationsImplications of this study include the refocus of attention onto the local and global environmental impacts of the Iraqi oil and gas industry by foreign direct investments. Such a refocus highlights the reasons and ways that decision makers should accommodate these less salient stakeholders.Originality/valueThe primary contribution is the critique of the lack of environmental accountability of foreign direct investment companies in the Iraqi oil and gas industry. The authors also make theoretical and methodological contributions via the problematisation of the cultural bias inherent in traditional stakeholder theories, and by introducing a quantitative method to evaluate the accountabilities of companies.
Numerical study on influence of inclination and sinusoidal heating on magneto-convection in an inclined lid-driven cavity
Authors: Sivanandam Sivasankaran , Marimuthu Bhuvaneswari 
Published: February 2023

PurposeThe numerical analysis is to scrutinize the collective effect of convective current along with the thermal energy transport in an inclined lid-driven square chamber with sine curve based temperature at the lower wall in the existence of unchanging external magnetic field. Insulation has been placed on the left and right of the box to increase the effective space volume of the shell. The thermal condition at ceiling wall is kept lower than the one on the floor.Design/methodology/approachThe finite volume method employs to discretize (non-dimensional) system of equations govern the model. The heat transfer rate is measured by adjusting various variables, such as the Richardson number Hartmann number, inclination of an enclosure.FindingsThe flow behavior of enclosure convection is more highly influenced within the natural convection when enclosure inclination varies as well as magnetic field strength. The overall heat transfer rate decreases due to increase in both the Hartmann number as well as Richardson number.Practical implicationsThe results of the present study are very useful to the cooling of electronic equipments.Social implicationsThe study model is useful to the thermal science community and modelling field.Originality/valueThis research is a novel work on mixed convection flow in an inclined chamber with sinusoidal heat source.
A review of the interrelationships and characteristics of Building Information Modeling, Integrated Project Delivery and Lean Construction maturity models
Authors: Rashidian Sara , Drogemuller Robin , Omrani Sara , Banakar Fereshteh 
Published: February 2023

PurposeThe application of integrated project delivery (IPD) in conjunction with building information modeling (BIM) and Lean Construction (LC) as the efficient method for improving collaboration and delivering construction projects has been acknowledged by construction academics and professionals. Once organizations have fully embraced BIM, IPD and LC integration, a measurement tool such as a maturity model (MM) for benchmarking their progress and setting realistic goals for continuous improvement will be required. In the context of MMs literature, however, no comprehensive analysis of these three construction management methods has been published to reveal the current trends and common themes in which the models have approached each other.Design/methodology/approachTherefore, this study integrates systematic literature review (SLR) and thematic analysis techniques to review and categorize the related MMs; the key themes in which the interrelationship between BIM, IPD and LC MMs has been discussed and conceptualized in the attributes; the shared characteristics of the existing BIM, IPD and LC MMs, as well as their strengths and limitations. The Preferred Reporting Items for Systematic Reviews (PRISMA) method has been used as the primary procedure for article screening and reviewing published papers between 2007 and 2022.FindingsDespite the growth of BIM, IPD and LC integration publications and acknowledgment in the literature, no MM has been established that holistically measures BIM, IPD and LC integration in an organization. This study identifies five interrelated and overlapping themes indicative of the collaboration of BIM, IPD and LC in existing MMs' structure, including customer satisfaction, waste minimization, Lean practices and cultural and legal aspects. Furthermore, the MMs' common characteristics, strengths and limitations are evaluated to provide a foundation for developing future BIM, IPD and LC-related MMs.Practical implicationsThis paper examines the current status of research and the knowledge gaps around BIM, IPD and LC MMs. In addition, the highlighted major themes serve as a foundation for academics who intend to develop integrated BIM, IPD, and LC MMs. This will enable researchers to build upon these themes and establish a comprehensive list of maturity attributes fulfilling the BIM, IPD and LC requirements and principles. In addition, the MMs' BIM, IPD and LC compatibility themes, which go beyond themes' intended characteristics in silos, increase industry practitioners' awareness of the underlying factors of BIM, IPD and LC integration.Originality/valueThis review article is the first of a kind to analyze the interaction of IPD, BIM and LC in the context of MMs in current AEC literature. This study concludes that BIM, IPD and LC share several joint cornerstones according to the existing MMs.
Assessing children to identify developmental coordination disorder: A survey of occupational therapists in Australia
Authors: Hunt Jacqui , Zwicker Jill , Godecke Erin , Raynor Annette 
Published: February 2023

AbstractBackgroundDevelopmental coordination disorder (DCD), a prevalent neurodevelopmental disorder with motor and psychosocial consequences, can significantly impact children's quality of life. In Australia, most children with diagnosed/suspected DCD have received occupational therapy services, more so than any other health service. As such, occupational therapists are key in identification and treatment and require a sound knowledge of diagnostic criteria and the best evidence for practice. This study explored current occupational therapy services for children with DCD. Areas for development are identified to improve the identification of, and subsequent intervention for, children with DCD.MethodsIn this cross‐sectional study, an online survey was completed in September and October 2020 by 175 occupational therapists working in Australia.ResultsAlthough all therapists worked with children who met the criteria for DCD diagnosis, 70% worked with children with no specific diagnosis and 50% worked with children with outdated diagnostic labels. Australian occupational therapists used similar models/frameworks (commonly a multisensory/sensory processing approach) to guide practice with children with DCD, regardless of therapist characteristics, practice setting (clinic/community, rural/urban), how therapy is funded, or the state where the therapists completed their training/currently practiced. Although assessment practices did not differ significantly, therapists with greater years of paediatric practice and those who studied and/or practiced in Western Australia were more likely to assess to identify DCD. Half of the therapists did not assess to identify DCD; however, 60% of assessing therapists reported best practice methods in assessment for DCD, indicating emerging best practices in the Australian context.ConclusionThe findings from this study suggest that small adaptations to current occupational therapy practice may enhance the early identification of children with DCD in Australia. The existing gaps in evidence to practice must be addressed to improve current Australian practice and increase access to appropriate services and ultimately improve the quality of life for children with DCD.
Limited sampling strategy to predict free mycophenolic acid area under the concentration–time curve in paediatric patients with nephrotic syndrome
Authors: Sobiak Joanna , Żero Paweł , Zachwieja Jacek , Ostalska‐Nowicka Danuta , Pawiński Tomasz 
Published: February 2023

AbstractIn paediatric patients, there is no data on the recommended area under the concentration–time curve from 0 to 12 h (AUC0−12) for free mycophenolic acid (fMPA), which is the active form of the drug, responsible for the pharmacological effect. We decided to establish the limited sampling strategy (LSS) for fMPA for its use in MPA therapeutic monitoring in children with nephrotic syndrome treated with mycophenolate mofetil (MMF). This study included 23 children (aged 11 ± 4 years) from whom eight blood samples were collected within 12 h after MMF administration. The fMPA was determined using the high‐performance liquid chromatography with fluorescence detection method. LSSs were estimated with the use of R software and bootstrap procedure. The best model was chosen based on a number of profiles with AUC predicted within ± 20% of AUC0−12 (good guess), r2, mean prediction error (%MPE) of ±10% and mean absolute error (%MAE) of less than 25%. The fMPA AUC0−12 was 0.1669 ± 0.0697 μg h/mL and the free fraction was within 0.16%–0.81%. In total, there were 92 equations developed of which five fulfilled the acceptance criteria for %MPE, %MAE, good guess >80% and r2 > 0.900. These equations consisted of three time points: model 1 (C1, C2, C6), model 2 (C1, C3, C6), model 3 (C1, C4, C6), model 5 (C0, C1, C2), and model 6 (C1, C2, C9). Although blood sampling up to 9 h after MMF dosing is impractical, it is crucial to include C6 or C9 in LSS to assess fMPA AUCpred correctly. The most practical fMPA LSS, which fulfilled the acceptance criteria in the estimation group, was fMPA AUCpred = 0.040 + 2.220 × C0 + 1.130 × C1 + 1.742 × C2. Further studies should define the recommended fMPA AUC0−12 value in children with nephrotic syndrome.
Jacques de Vitry (d. 1240) and the Religious Life of his Time
Authors: BARTLETT ROBERT 
Published: February 2023

AbstractIn this article the scholar, preacher and bishop Jacques de Vitry (d. 1240) is taken as a vantage point to look at the religious life of his time. He had personal involvement with the nascent university of Paris, the earliest beguines of the Low Countries, the crusades against heretics and Muslims, and the first friars. He left varied and vivid descriptions of these movements. His writings also constantly reveal a counter‐current of scepticism and derision on the part of those who dismissed these religious movements as sanctimonious or hypocritical.
Writing Doctors, Body Work, and Body Texts in the French Revolution
Authors: Broomhall Susan 
Published: February 2023

AbstractThis paper explores the construction of the identities of Philippe Curtius and his protégé Marie Grosholtz, known as Madame Tussaud, as providers of medical and health services, body workers, and entrepreneurs in key works that charted their experiences during the volatile period of the French Revolution. As purveyors of entertainment that derived its attraction from perceived close rendering of the likenesses of noteworthy individuals, modellers in wax required attentive discernment of bodies, or at least the capacity for imaginative descriptive skills, establishing a professional language for body work. Moreover, Tussaud's account explicitly foregrounds complex gender dynamics as a young woman interacting with the bodies of male and female clients. This essay explores how important eighteenth‐century gendered conceptualizations of body work are revealed in the body texts produced in this period.
Bio‐citizens online: A content analysis of pro‐ana and weight loss blogs
Authors: Sheppard Amy , Ricciardelli Rose 
Published: February 2023

AbstractCurrent neoliberal ideology in Western society encourages individuals to self‐monitor their body to control population health. The resulting self‐surveillance includes weight management, promoted as a marker of health. Disordered eating, like anorexia, is framed as a health disorder. However, weight loss is framed as a health initiative; we argue that these framings are engaging with the same body project, encouraging thinness as a marker of health and good bio‐citizenry. Using content analysis to compare online blog context created by individuals engaged in weight loss and individuals who identify as pro‐anorexia, we argue and evidence that both groups are engaged in body projects with shared parameters. Findings suggest each group is striving to embody a thin ideal through weight management. Specifically, weight loss bloggers and pro‐ana bloggers demonstrate similar diet and exercise behaviours in online diaries detailing their weight loss experiences. Thus, weight loss and anorexia exist on the same spectrum of responsible bio‐citizenry.