bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of CytoSorb® on interleukin-6 in cardiac surgery
Authors: Geisler Daniela , Arleth Noemi , Grabenwöger Johannes , Arnold Zsuzsanna , Aschacher Thomas , Winkler Bernhard , Mach Markus , Grabenwöger Martin 
Published: August 2023

ObjectiveCardiac surgery is known to activate a cascade of inflammatory mediators leading to a systemic inflammatory response. Hemadsorption (HA) devices such as CytoSorb® have been postulated to mitigate an overshooting immune response, which is associated with increased morbidity and mortality, and thus improve outcome. We aimed to investigate the effect of CytoSorb® on interleukin (IL)-6 levels in patients undergoing complex cardiac surgery in comparison to a control group.MethodsA total of 56 patients (28 CytoSorb®, 28 control) undergoing acute and elective cardiac surgery between January 2020 and February 2021 at the Department of Cardiac and Vascular Surgery, Clinic Floridsdorf, Vienna, were retrospectively analyzed. The primary endpoint was the difference in IL-6 levels between the CytoSorb® and control group. Secondary endpoint was periprocedural mortality.ResultsCytoSorb®, installed in the bypass circuit, had no significant effect on IL-6 levels. IL-6 peaked on the first postoperative day (HA: 775.3 ± 838.4 vs. control: 855.5 ± 1,052.9 pg/ml, p = 0.856). In total, three patients died in the HA group, none in the control (logistic regression model, p = 0.996). Patients with an increased Euroscore II of 7 or more showed a reduced IL-6 response compared to patients with an Euroscore II below 7 (178.3 ± 63.1 pg/ml vs. 908.6 ± 972.6 pg/ml, p-value = 0.00306).ConclusionsNo significant reduction of IL-6 levels or periprocedural mortality through intraoperative HA with CytoSorb® in patients undergoing cardiac surgery was observed. However, this study was able to show a reduced immunologic response in patients with a high Euroscore II. The routine application of CytoSorb® in cardiac surgery to reduce inflammatory mediators has to be scrutinized in future prospective randomized studies.
Safety, accuracy, and prediction of prognosis in patients with end-stage chronic kidney disease undergoing dobutamine stress cardiac magnetic resonance imaging
Authors: Weberling Lukas D. , Seitz Sebastian , Salatzki Janek , Ochs Andreas , Haney Ailís C. , Siry Deborah , Heins Jannick , Steen Henning , Frey Norbert , André Florian 
Published: August 2023

IntroductionAdvanced chronic kidney disease (CKD) is an independent risk factor for coronary artery disease (CAD). Due to its unique uremia-derived pathophysiology of atherosclerosis and the limitations of using potentially harmful contrast agents, the best non-invasive approach to assess CAD in these patients remains unclear. We sought to investigate the accuracy, safety, and prognosis of patients with severe CKD undergoing dobutamine stress cardiac magnetic resonance imaging (CMR).Materials and methodsIn this retrospective, single-center study, patients on dialysis or with a glomerular filtration rate of &lt;15 ml/min/1.73 m2 who underwent dobutamine stress CMR were included. A rest and stress wall motion analysis was performed using dobutamine/atropine as stressor. The target heart rate was 85% of the maximum heart rate. Periprocedural adverse events and 1-year follow-up data were obtained.ResultsA total of 176 patients (127 men, 49 women) with a mean age of 60.9 ± 14.7 years were included, of which 156 patients were on permanent dialysis. Short-term symptoms such as angina or shortness of breath during stress CMR were frequent (22.1%), but major complications were rare (one patient with myocardial infarction, 0.6%). The 1-year event rate was high (16.4%) with a significant independent correlation to reduced ejection fraction at rest (p = 0.037) and failure to achieve the target heart rate (p = 0.029). The overall accuracy for predicting significant CAD was good (sensitivity of 71.4%, specificity of 98.4%) and excellent if the target heart rate was achieved (83.3%, 97.9%). A negative stress CMR was highly predictive for the absence of major adverse cardiac event or any coronary revascularization during the 1-year follow-up (negative predictive value of 95.0%).DiscussionDobutamine stress CMR is a safe and accurate diagnostic imaging technique in patients at advanced stages of chronic kidney disease. A reduced ejection fraction and the inability to reach the target heart rate are independent predictors of a poor outcome.
Association of systemic immune inflammation index and system inflammation response index with clinical risk of acute myocardial infarction
Authors: Wei Xing , Zhang Zhipeng , Wei Jing , Luo Chunmiao 
Published: August 2023

BackgroundSystemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) are combinations of non-specific inflammatory and adaptive immune response impairments associated with cardiovascular disease. Yet little analysis has been done on SII, SIRI and acute myocardial infarction (AMI) prognosis. The purpose of this study was to investigate the correlation of SII and SIRI with clinical risk factors such as GRACE, Gensini, and QTc after acute myocardial infarction.MethodsThis study enrolled 310 patients with AMI from February 1, 2018, to December 31, 2022, at our institution. Routine blood items calculated SII and SIRI. Two groups were divided according to whether MACE occurred: the MACE group (81 cases) and the NMACE group (229 cases); each group was divided into three groups according to the SII and SIRI tertiles. The relationship between SII, SIRI and MACE was analyzed using multifactorial logistic regression analysis after adjusting for confounders; ROC curves were plotted to examine the predictive value of SII and SIRI for MACE. The correlation between SII and SIRI and potential risk factors such as Gensini, QTc and GRACE was further analyzed.ResultsThe study enrolled 310 patients, comprising 248 men (80%, mean age 60.73 ± 13.695 years) and 62 women (20%, mean age 69.79 ± 11.555 years). In the regression model completely adjusted for confounders, the risk of MACE was higher in AMI patients with SII &gt; 11.00 [OR = 1.061,95% CI (1.018,1.105)] than in SII &lt; 5.98; the risk of MACE was 115.3% higher in AMI patients with SIRI (1.72–3.68) [OR = 2.153, 95% CI (1.251, 3.705)] was 115.3% higher in AMI patients with SIRI &lt; 1.72 and the risk of MACE was 25.1% higher in AMI patients with SIRI &gt; 3.68 [OR = 1.251, 95% CI (1.123, 1.394)] than in AMI patients with SIRI &lt; 1.72. In addition, SII, SIRI, and potential post-infarction risk factors (Gensini, QTc, and GRACE) were also associated.ConclusionSII and SIRI have been significantly associated with post-myocardial infarction MACE and the predictive potential clinically integrated risk factors in AMI patients, for which more attention should be paid to targeted anti-inflammatory therapy in AMI patients to further reduce the incidence of prognostic MACE in AMI patients.
Marianismo and the changing role of Latinas in educational leadership
Authors: Salazar Montoya LeAnne C. , Kew Kristin 
Published: August 2023

This article focuses on the testimonios of accomplished Latina school leaders, shedding light on their upbringing, familial responsibilities, generational poverty, and commitment to challenge the prevailing narrative and break through institutional barriers. We provide an overview of how they shaped and navigated their professional careers despite various barriers and how they blazed new trails for future generations. Cultural norms, familial responsibilities, and uncommon mentorship models for Latina school leaders are discussed. These leaders often missed family gatherings and children's events but had found ways to balance work and life and care for their loved ones. They acted as role models of professional success for their family, friends, and colleagues. They were windows, mirrors, and sliding glass doors for those needing their support.RecommendationsThe women in our research serve as mentors (referred to as femtors) to other women in their fields. Through their achievements, they challenge and overcome the glass ceilings imposed by hegemonic systemic structures that favor and maintain existing social hierarchies by breaking through them. These structures often contribute to the marginalization of certain groups. Our findings from these testimonios fully capture the authenticity and essence of the participants' lived experiences while utilizing a feminist framework to construct research. The themes that emerged include (1) fostering a professional community linking one to other educational professionals, (2) participating in structured mentorship development programs throughout your career, (3) remaining a lifelong learner, (4) fostering professional relationships, and (5) remaining confident yet humble, and being one's authentic self. Finally, as the former Chancellor of New York Schools, Richard Carranza, often says, “Do not get lost trying to keep your job that you forget to do your job.” Our research delves into how these factors have led to their professional success and positioned them at the forefront of their fields. The pathways of the women in this study were similar in that their decisions led to positions of authority, namely superintendency, and gaining recognition for breaking through the traditional glass ceiling. We must consider whether generations of Latinas did not pursue careers or leadership positions outside their homes due to what they felt were their cultural and family obligations. Many agree that marianismo has prevented Latinas from reaching their goals.
Research on explosive damage effects of tungsten fiber-reinforced Zr-based bulk metallic glass matrix composite shell
Authors: Xing Bingnan , Du Chengxin , Du Zhonghua , Fu Huameng , Zhu Zhengwang , Zhou Feng 
Published: August 2023

To expand the application range of explosive fragmentation projectiles, tungsten fiber-reinforced bulk metallic glass matrix composite (WF/Zr-MG) is used as the warhead shell in static explosion experiments, and is compared with 40CrMnSiB steel shells. The experimental results showed that, compared with 40CrMnSiB steel shells, the fragments produced by the WF/Zr-MG shell exhibit a larger aspect ratio, smaller average size, and a greater number of fragments at distances of 3 m and 5 m, with an equal number of fragments at a distance of 8 m. Theoretical calculations showed that the initial velocity of the fragments produced by the WF/Zr-MG shell is lower, but their velocity decay is slower, resulting in a greater determined damage range. The research results showed that WF/Zr-MG can be used as a shell material for explosive fragmentation projectiles, which can enhance their destructive power.
Immunohistochemical distribution of secretagogin in the mouse brain
Authors: Téllez de Meneses Pablo G. , Pérez-Revuelta Laura , Canal-Alonso Ángel , Hernández-Pérez Carlos , Cocho Teresa , Valero Jorge , Weruaga Eduardo , Díaz David , Alonso José R. 
Published: August 2023

IntroductionCalcium is essential for the correct functioning of the central nervous system, and calcium-binding proteins help to finely regulate its concentration. Whereas some calcium-binding proteins such as calmodulin are ubiquitous and are present in many cell types, others such as calbindin, calretinin, and parvalbumin are expressed in specific neuronal populations. Secretagogin belongs to this latter group and its distribution throughout the brain is only partially known. In the present work, the distribution of secretagogin-immunopositive cells was studied in the entire brain of healthy adult mice.MethodsAdult male C57BL/DBA mice aged between 5 and 7 months were used. Their whole brain was sectioned and used for immunohistochemistry. Specific neural populations were observed in different zones and nuclei identified according to Paxinos mouse brain atlas.ResultsLabelled cells were found with a Golgi-like staining, allowing an excellent characterization of their dendritic and axonal arborizations. Many secretagogin-positive cells were observed along different encephalic regions, especially in the olfactory bulb, basal ganglia, and hypothalamus. Immunostained populations were very heterogenous in both size and distribution, as some nuclei presented labelling in their entire extension, but in others, only scattered cells were present.DiscussionSecretagogin can provide a more complete vision of calcium-buffering mechanisms in the brain, and can be a useful neuronal marker in different brain areas for specific populations.
Impact of biological rhythms on the importance hierarchy of constituents in time-dependent functional brain networks
Authors: Bröhl Timo , von Wrede Randi , Lehnertz Klaus 
Published: August 2023

Biological rhythms are natural, endogenous cycles with period lengths ranging from less than 24 h (ultradian rhythms) to more than 24 h (infradian rhythms). The impact of the circadian rhythm (approximately 24 h) and ultradian rhythms on spectral characteristics of electroencephalographic (EEG) signals has been investigated for more than half a century. Yet, only little is known on how biological rhythms influence the properties of EEG-derived evolving functional brain networks. Here, we derive such networks from multiday, multichannel EEG recordings and use different centrality concepts to assess the time-varying importance hierarchy of the networks’ vertices and edges as well as the various aspects of their structural integration in the network. We observe strong circadian and ultradian influences that highlight distinct subnetworks in the evolving functional brain networks. Our findings indicate the existence of a vital and fundamental subnetwork that is rather generally involved in ongoing brain activities during wakefulness and sleep.
Myocardial infarction impaired wall mechanics and hemodynamics in peripheral arteries
Authors: Xue Qiang , Shi Hongyu , Li Li , Jin Qing , Wang Xuan , Huo Yunlong 
Published: August 2023

Myocardial infarction (MI) impaired both cardiac functions and peripheral arteries. The changes in normal and shear stresses in the peripheral artery wall are of importance for understanding the progression of MI-induced heart failure (HF). The aim of the study is to investigate the corresponding changes of normal and shear stresses. The coronary artery ligation was used to induce the MI in Wistar rats. The analysis of wall mechanics and hemodynamics was performed based on in vivo and in vitro measurements. Myocardial infarction increased wall stiffness in elastic carotid and muscular femoral arteries significantly albeit different changes occurred between the two vessels from 3 to 6 weeks postoperatively. Moreover, the hemodynamic analysis showed the gradually deteriorated wall shear stress, oscillatory shear index and relative residence time in the two arteries. This study probably shed light on understanding the interaction between abnormal systemic circulation and peripheral mechanics and hemodynamics during the development of MI-induced HF.
Words for the hearts: a corpus study of metaphors in online depression communities
Authors: Shi Jiayi , Khoo Zhaowei 
Published: August 2023

Purpose/significanceHumans understand, think, and express themselves through metaphors. The current paper emphasizes the importance of identifying the metaphorical language used in online health communities (OHC) to understand how users frame and make sense of their experiences, which can boost the effectiveness of counseling and interventions for this population.Methods/processWe used a web crawler to obtain a corpus of an online depression community. We introduced a three-stage procedure for metaphor identification in a Chinese Corpus: (1) combine MIPVU to identify metaphorical expressions (ME) bottom-up and formulate preliminary working hypotheses; (2) collect more ME top-down in the corpus by performing semantic domain analysis on identified ME; and (3) analyze ME and categorize conceptual metaphors using a reference list. In this way, we have gained a greater understanding of how depression sufferers conceptualize their experience metaphorically in an under-represented language in the literature (Chinese) of a new genre (online health community).Results/conclusionMain conceptual metaphors for depression are classified into PERSONAL LIFE, INTERPERSONAL RELATIONSHIP, TIME, and CYBERCULTURE metaphors. Identifying depression metaphors in the Chinese corpus pinpoints the sociocultural environment people with depression are experiencing: lack of offline support, social stigmatization, and substitutability of offline support with online support. We confirm a number of depression metaphors found in other languages, providing a theoretical basis for researching, identifying, and treating depression in multilingual settings. Our study also identifies new metaphors with source-target connections based on embodied, sociocultural, and idiosyncratic levels. From these three levels, we analyze metaphor research’s theoretical and practical implications, finding ways to emphasize its inherent cross-disciplinarity meaningfully.
Advanced Hybrid Closed Loop users’ satisfaction of telemedicine and telenursing in pediatric and young adult type 1 diabetes
Authors: Bassi Marta , Dufour Francesca , Strati Marina Francesca , Franzone Daniele , Scalas Marta , Lionetti Barbara , Spacco Giordano , Rizza Francesca , Sburlati Prisca , Casalini Emilio , Parodi Stefano , d’Annunzio Giuseppe , Minuto Nicola 
Published: August 2023

Background and aimsThe aim of the study was to evaluate the satisfaction of the use of telemedicine and telenursing in children and young adults with Type 1 Diabetes (T1D) using Advanced Hybrid Closed Loop systems (AHCL) with a focus on the role of connectivity, data download and the ease of technical steps in the set and sensor change procedures.MethodsAn online anonymous survey was administered to AHCL users. The questionnaire consisted of five Clusters: Cluster A-B-C included questions related to the general satisfaction in the use of telemedicine, Cluster D was focused on the role of data download and connectivity, Cluster E was related to satisfaction in telenursing and Cluster F to the perception of ease of execution of the technical steps like changing the infusion set and the sensor.ResultsWe collected 136 completed questionnaires. 83.8% of AHCL users were overall satisfied with the quality of the telemedicine service. 88.2% of patients downloaded AHCL data before visits and the overall quality of televisits (data sharing, connectivity, ease of use) was satisfactory for 85.3% of users. Telenursing support during set and sensor change procedures was considered effective by 98% of AHCL users. The sensor and insulin infusion set change procedure is perceived as different for the two systems: set change simpler for Medtronic (p = 0.011) users, while sensor change was simpler for Tandem users (p = 0.009).ConclusionTelemedicine and telenursing have an essential role in diabetology and are highly appreciated in AHCL users. The nurse support in the education of the use of AHCL systems is effective and must be implemented. Unfortunately, not all patients have the technological tools needed for downloading data at home and using telemedicine services; this represents an important challenge for the future of diabetology and for the equity in accessibility to care.
Urban Governance, Multisectoral Action, and Civic Engagement for Population Health, Wellbeing, and Equity in Urban Settings: A Systematic Review
Authors: Mesa-Vieira Cristina , Gonzalez-Jaramillo Nathalia , Díaz-Ríos Catalina , Pano Octavio , Meyer Sophie , Menassa Marilyne , Minder Beatrice , Lin Vivian , Franco Oscar H. , Frahsa Annika 
Published: August 2023

Objectives: To identify the validated and reliable indicators and tools to assess good governance for population health, wellbeing, and equity in urban settings, and assess processes of multisectoral action and civic engagement as reported by peer-reviewed articles.Methods: We conducted a systematic review searching six databases for observational studies reporting strategies of either urban health, multisectoral action or civic engagement for wellbeing, health, or equity.Results: Out of 8,154 studies initially identified we included 17. From the included studies, 14 presented information about high-income countries. The general population was the main target in most studies. Multisectoral action was the most frequently reported strategy (14 studies). Three studies used Urban Health Equity Assessment and Response Tool (Urban HEART). Health indicators were the most frequently represented (6 studies). Barriers and facilitators for the implementation of participatory health governance strategies were reported in 12 studies.Conclusion: Data on the implementation of participatory health governance strategies has been mainly reported in high-income countries. Updated and reliable data, measured repeatedly, is needed to closely monitor these processes and further develop indicators to assess their impact on population health, wellbeing, and equity.
Impact of Seasonality on Copper Bioavailaility to Crabs (Ucides cordatus, Linnaeus, 1763) in Mangrove Soils of Todos os Santos Bay (Bahia, North Eastern Brazil)
Authors: Ramos Mônica A. V. , Nóbrega Gabriel N. , Ferreira Tiago. O. , Otero Xosé L. 
Published: August 2023

Crab and soil samples were seasonally collected at four mangrove sites (Cacha Prego, CP; Ponta Grossa, PG; Ilha de Maré, IM; and Pitinga, PT) in Todos os Santos Bay, in NE Brazil. Total Cu levels in soils ranged from 2.5 to 89.4 mg kg−1, while in crab organs (muscles, hepatopancreas, and gills), Cu ranged from 20 to 1,320 mg kg−1, with the highest concentrations found in the Ilha de Maré population, where soils showed a clear Cu enrichment. Total Cu content did not explain the abnormally high Cu concentrations observed in crabs from Pitinga, where total content in soil was low. Geochemical partitioning indicated that most of the potentially bioavailable Cu was found in the oxidizable fractions, pyrite and organic matter. Pyrite oxidation during the dry season led to increased Cu bioavailability. This process was of relevance in soils of the Pitinga mangrove, where sulfide oxidation led to soil acidification and to an increase in Cu associated with the most labile fractions.
Actual Problem to Diagnostic and Treatment Onychomycosis
Authors: Рахматов А.Б. , Утаев А.Д. 
Published: August 2023

При лечении 40 пациентов с различными формами онихомикозов был использован Nd:YAG-лазер (1064 нм), позволивший у 95% пациентов получить клинико-микологическое выздоровление, наряду с минимальными побочными эффектами, которые могут встречаться при системной антимикотической терапии.
In the treatment of 40 patients with various forms of onychomycosis, an Nd:YAG laser (1064 nm) was used, which allowed 95% of patients to obtain clinical and mycological recovery, along with minimal side effects that may occur with systemic antimycotic therapy.