bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoconfinement‐Guided Construction of Nanozymes for Determining H2O2 Produced by Sonication
Authors: Li Tong , Wang Yuting , Liu Wanling , Fei Houguo , Guo Cunlan , Wei Hui 
Published: January 2023

AbstractNanomaterials with enzyme‐like activities, termed as nanozymes, have found wide applications in various fields. It has been a long‐term aim to rationally design and synthesize highly active nanozymes and thus to further improve their application performance. Guided by the nanoconfinement effect, we confine cytochrome c (Cyt c) within a mesoporous metal–organic framework (MOF), PCN‐222 nanoparticle (NP), forming a protein/MOF hybrid nanozyme, termed as Cyt c@PCN‐222 NP. The confined Cyt c exhibits around 3–4‐fold higher peroxidase‐like activity than free Cyt c. Due to the increase in the activity of Cyt c, the Cyt c@PCN‐222 NPs exhibit a quite low limit of detection (≈0.13 μM) towards H2O2. Sonication‐induced H2O2 formation in water by using a lab‐quipped ultrasonic cleaner can be sensitively probed, which suggests that H2O2‐sensitive materials should be carefully handled during the utilization of ultrasonic equipment. We speculate that this nanoconfinement strategy can broaden our synthetic methodology for the rational design of nanozymes.
Visible‐Light Promoted Intramolecular para‐Cycloadditions on Simple Aromatics
Authors: Chiminelli Maurizio , Serafino Andrea , Ruggeri Davide , Marchiò Luciano , Bigi Franca , Maggi Raimondo , Malacria Max , Maestri Giovanni 
Published: January 2023

AbstractDearomative cycloadditions are a powerful tool to access a large chemical space exploiting simple and ubiquitous building blocks. The energetic burden due to the loss of aromaticity has however greatly limited their synthetic potential. We devised a general intramolecular method that overcomes these limitations thanks to the photosensitization of allenamides. The visible‐light‐promoted process gives complex [2.2.2]‐(hetero)‐bicyclooctadienes at room temperature, likely through the stabilization of transient (bi)radicals by naphthalene. The reaction tolerates several valuable functionalities, offering a convenient handle for a myriad of applications, including original isoindoles and metal complexes.
Prebiotic Synthesis and Isomerization in Interstellar Analog Ice: Glycinal, Acetamide, and Their Enol Tautomers
Authors: Marks Joshua H. , Wang Jia , Kleimeier N. Fabian , Turner Andrew M. , Eckhardt André K. , Kaiser Ralf I. 
Published: January 2023

AbstractGlycinal (HCOCH2NH2) and acetamide (CH3CONH2) are simple molecular building blocks of biomolecules in prebiotic chemistry, though their origin on early Earth and formation in interstellar media remain a mystery. These molecules are formed with their tautomers in low temperature interstellar model ices upon interaction with simulated galactic cosmic rays. Glycinal and acetamide are accessed via barrierless radical‐radical reactions of vinoxy (⋅CH2CHO) and acetyl (⋅C(O)CH3), and then undergo keto‐enol tautomerization. Exploiting tunable photoionization reflectron time‐of‐flight mass spectroscopy and photoionization efficiency (PIE) curves, these results demonstrate fundamental reaction pathways for the formation of complex organics through non‐equilibrium ice reactions in cold molecular cloud environments. These molecules demonstrate an unconventional starting point for abiotic synthesis of organics relevant to contemporary biomolecules like polypeptides and cell membranes in deep space.
Developmentally Appropriate Care of Pediatric Patients in the Perioperative Setting
Authors: Musselman Elaine , Shea Kathleen , Johnson Lora 
Published: January 2023

ABSTRACTPediatric patients do not undergo procedures exclusively at pediatric specialty facilities. Many perioperative nurses will care for a pediatric patient at some point in their career. Children and their caregivers often experience elevated levels of anxiety during the perioperative experience. Possessing knowledge of the child's age and developmental stage and using effective communication techniques can decrease this anxiety. This article presents insights into the stages of pediatric cognitive and psychosocial development and special pediatric health care considerations. Approaching and interacting with a child in a manner appropriate for their age and developmental stage can foster a more trusting nurse‐child‐caregiver relationship and reassure the caregiver that the perioperative team is providing their child with safe, high‐quality care. Also included are five hypothetical case studies that illustrate effective communication styles and developmentally appropriate techniques that personnel can apply during the pediatric patient's perioperative experience.
Clinical Issues — February 2023
Authors: deKay Karen 
Published: January 2023

THIS MONTH
Frequency of OR wall and ceiling cleaning
Key words: environmental surfaces, high‐touch surfaces, contamination, cleaning frequency, hand contact.
Waterborne pathogen development and associated risks
Key words: Legionella, premise plumbing system, opportunistic pathogens, biofilm, electronic sensor faucet.
Water management program teams and perioperative services
Key words: water supply safety, facility water system, waterborne pathogen prevention plan, faucets, drains.
Minimizing waterborne pathogens in perioperative areas
Key words: waterborne pathogen dispersal, cross contamination, splash guards, high‐risk hardware, sinks.
Bio‐based novolac resins from cashew nut processing waste: Alternative resource for the development of high‐value sustainable products
Authors: da Silva Kássia Teixeira , Oliveira Beatriz S. , da Silva Lucas R. R. , Mattos Adriano L. A. , Mazzetto Selma E. , Lomonaco Diego 
Published: January 2023

AbstractIn the last decades, there is an increasing trend for replacing petro‐based adhesives with sustainable and eco‐friendly alternatives, especially in the wood industry. In this work it was developed and characterized novolac‐type phenolic resins from the full use of the cashew nut shell liquid (CNSL), an agro‐industrial residue and a rich source of phenolic compounds, sustainable alternative to petroleum‐derived chemicals, to develop bio‐based polymers. CNSL and paraformaldehyde were reacted, using oxalic acid as a catalyst, under a solvent‐free methodology. A dark and viscous resin of high molar mass and thermally stable was obtained. The development of highly bio‐based adhesives was proposed by combining CNSL‐based novolac resin (CNSL‐nov) with commercial epoxy resin (DGEBA), as an alternative to conventional hardeners. The use of the epoxy‐novolac system proved to be efficient and promising in obtaining new highly cross‐linked polymers with excellent thermal performance and with potential for wood industry, improving the bio‐based content of high‐performance adhesive.
Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin
Authors: Hile Grace A. , Coit Patrick , Xu Bin , Victory Amanda M. , Gharaee‐Kermani Mehrnaz , Estadt Shannon N. , Maz Mitra P. , Martens Jacob W. S. , Wasikowski Rachael , Dobry Craig , Tsoi Lam C. , Iglesias‐Bartolome Ramiro , Berthier Celine C. , Billi Allison C. , Gudjonsson Johann E. , Sawalha Amr H. , Kahlenberg J. Michelle 
Published: January 2023

ObjectivePhotosensitivity is one of the most common manifestations of systemic lupus erythematosus (SLE), yet its pathogenesis is not well understood. The normal‐appearing epidermis of patients with SLE exhibits increased ultraviolet B (UVB)–driven cell death that persists in cell culture. Here, we investigated the role of epigenetic modification and Hippo signaling in enhanced UVB‐induced apoptosis seen in SLE keratinocytes.MethodsWe analyzed DNA methylation in cultured keratinocytes from SLE patients compared to keratinocytes from healthy controls (n = 6/group). Protein expression was validated in cultured keratinocytes using immunoblotting and immunofluorescence. An immortalized keratinocyte line overexpressing WWC1 was generated via lentiviral vector. WWC1‐driven changes were inhibited using a large tumor suppressor kinase 1/2 (LATS1/2) inhibitor (TRULI) and small interfering RNA (siRNA). The interaction between the Yes‐associated protein (YAP) and the transcriptional enhancer associate domain (TEAD) was inhibited by overexpression of an N/TERT cell line expressing a tetracycline‐inducible green fluorescent protein–tagged protein that inhibits YAP–TEAD binding (TEADi). Apoptosis was assessed using cleaved caspase 3/7 and TUNEL staining.ResultsHippo signaling was the top differentially methylated pathway in SLE versus control keratinocytes. SLE keratinocytes (n = 6) showed significant hypomethylation (Δβ = −0.153) and thus overexpression of the Hippo regulator WWC1 (P = 0.002). WWC1 overexpression increased LATS1/2 kinase activation, leading to YAP cytoplasmic retention and altered proapoptotic transcription in SLE keratinocytes. Accordingly, UVB‐mediated apoptosis in keratinocytes could be enhanced by WWC1 overexpression or YAP–TEAD inhibition, mimicking SLE keratinocytes. Importantly, inhibition of LATS1/2 with either the chemical inhibitor TRULI or siRNA effectively eliminated enhanced UVB‐apoptosis in SLE keratinocytes.ConclusionOur work unravels a novel driver of photosensitivity in SLE: overactive Hippo signaling in SLE keratinocytes restricts YAP transcriptional activity, leading to shifts that promote UVB apoptosis.image
Activation Mechanism of a Peroxymonosulfate‐based Fenton‐like System with Birnessite and Cu2+ Modified Birnessite
Authors: Guo Rujia , Hu Shiyu , Gao Yiqian , Chen Feng 
Published: January 2023

AbstractThe peroxymonosulfate (PMS) activation mechanism is closely related to the structure/configuration of the “active site” of the Fenton‐like catalysts. In this paper, it is shown that Cu2+ chemically bonds the surface of birnessite at the Mn vacancy site to form triple‐corner‐sharing inner‐sphere surface complexes (Cu‐Bir), which regulates the PMS activation mechanism. Birnessite/PMS Fenton‐like system degrades phenol via a non‐radical mechanism, which involves high valent Mn(V)=O generated from the surface reaction of Mn(III) with adsorbed PMS. While Cu‐Bir initiates an additional radical mechanism that involves reactive oxygen species of ⋅O2− and 1O2, and the k value of 5Cu‐Bir is 1.9 times higher than that of Bir. The Fenton‐like reaction mechanism of the Cu‐Bir/PMS system is thus proposed as a radical and non‐radical cooccurrence mechanism, which involves a synergistic effect that the radical pathway accelerates the regeneration of Mn(III) for the non‐radical pathway, and the non‐radical pathway assists to produce 1O2 for the radical pathway.
Surface‐enhanced Raman scattering integrating with machine learning for green tea storage time identification
Authors: Li Fan , Huang Yuting , Wang Xueqing , Wang Dongmei , Fan Meikun 
Published: January 2023

AbstractThe rapid and accurate identification of complex samples still remains a great challenge, especially for those with similar compositions. In this work, we report an integration strategy consisting of surface‐enhanced Raman scattering (SERS) and machine learning to discriminate complex and similar analytes, in this case green tea products with different storage times. Surface‐functionalized Ag nanoparticles (NPs) were used as a SERS substrate to reveal the changes in the sensory components of green tea with variable storage time. Principal components analysis (PCA)‐based support vector machine (SVM) classification was used to extract the key spectral features and identify green tea with different storage times. The results showed that such an integration strategy achieved high predictive accuracy on time tag discrimination for green tea. The multiclass SVM classifier successfully recognized green tea with different storage times at a prediction accuracy of 95.9%, sensitivity of 96.6%, and specificity of 98.8%. Therefore, this work illustrates that the SERS‐based PCA‐SVM platform might be a facile and reliable tool for the identification of complex matrices with subtle differentiations.
A novel membrane stirrer system enables foam‐free biosurfactant production
Authors: Bongartz Patrick , Karmainski Tobias , Meyer Moritz , Linkhorst John , Tiso Till , Blank Lars M. , Wessling Matthias 
Published: January 2023

AbstractBioreactors are the operative backbone, for example, for the production of biopharmaceuticals, biomaterials in tissue engineering, and sustainable substitutes for chemicals. Still, the Achilles' heel of bioreactors nowadays is the aeration which is based on intense stirring and gas sparging, yielding inherent drawbacks such as shear stress, foaming, and sterility concerns. We present the synergistic combination of simulations and experiments toward a membrane stirrer for the efficient bubble‐free aeration of bioreactors. A digital twin of the bioreactor with an integrated membrane‐module stirrer (MemStir) was developed with computational fluid dynamics (CFD) studies addressing the determination of fluid mixing, shear rates, and local oxygen concentration. Usability of the MemStir is shown in a foam‐free recombinant production process of biosurfactants (rhamnolipids) from glucose with different strains ofPseudomonas putidaKT2440 in a 3‐L vessel and benchmarked against a regular aerated process. The MemStir delivered a maximal oxygen transfer rate (OTRmax) of 175 mmol L−1h−1in completely foam‐free cultivations. With a high space‐time yield (STY) of 118 mgRLL−1h−1during a fed‐batch fermentation, the effectiveness of the novel MemStir is demonstrated. Simulations show the generic value of the MemStir beyond biosurfactant production, for example, for animal cell cultivation.
Extraction, Purification and Electrical Characterization of Gross Galactomannan and Purified Galactomannan Obtained from Adenanthera pavonina L. Seeds
Authors: Silva Neto J. F. , Pereira W. O. , Cavalcante L. A. , Oliveira Neto J. G. , Graça M. P. F. , Gavinho S. R. , Amaral F. M. B. , Santos A. O. , Sombra A. S. B. , Mendes Fernando , Macêdo A. A. M. 
Published: January 2023

AbstractAiming of self‐sustainable production, the search for biodegradable and biocompatible materials has brought with it the need to know the physicochemical and dielectric characteristics of polysaccharide‐based composite structures, which can be used as important and promising raw materials for biotechnology and electronic industries. Galactomannans are polysaccharides, extracted from seeds and microbiological sources, consisting of mannose and galactose. In this context, this work aimed to extract, purify and characterize by XRD, FTIR and impedance spectroscopy galactomannan obtained from seeds of Adenanthera pavonina L. The purification process was made with ethyl alcohol at concentrations of 70, 80 and 90 %. Polymeric films were prepared by solvent slow evaporation at low temperatures. XRD measurements revealed that Galactomannan from Adenanthera pavonina L., after purification, has a semi‐crystalline structure due to the identification of two peaks the first between 5.849° and 6.118° and the second between 20.011° and 20.247°. FTIR spectra showed the functional groups associated with monosaccharides of the galactomannan from Adenanthera pavonina L. seeds, as well as the typical polysaccharide bands and peaks, confirmed by literature data. The impedance results give an increment on the state‐of‐the‐art of this biomaterial by showing the existence of dielectric relaxations, independent of the degree of purification, using the dielectric modulus formalism. The permittivity analysis reveals the presence of water in the structure of the film, whose dipoles contribute to the relatively high value of the dielectric constant. From the results obtained, it can be concluded that purified galactomannan has the potential for possible applications in the electronics industry as a green and eco‐friendly dielectric material.
The Preventive and Therapeutic Potential of the Flavonoids in Liver Cirrhosis: Current and Future Perspectives
Authors: Sahu Rakesh , Goswami Sourav , Narahari Sastry G. , Rawal Ravindra K. 
Published: January 2023

AbstractNon‐alcoholic fatty liver disease (NAFLD) may vary from moderately mild non‐alcohol fatty liver (NAFL) towards the malignant variant known as non‐alcoholic steatohepatitis (NASH), which is marked by fatty liver inflammation and may progress to liver cirrhosis (LC), liver cancer, fibrosis, or liver failure. Flavonoids can protect the liver from toxins through their anti‐inflammatory, antioxidant, anti‐cancer, and antifibrogenic pharmacological activities. Furthermore, flavonoids protect against LC by regulation of hepatic stellate cells (HSCs) trans‐differentiation, inhibiting growth factors like TGF‐β and platelets‐derived growth factor (PDGF), vascular epithelial growth factor (VEGF), viral infections like hepatitis‐B, C and D viruses (HBV, HCV & HDV), autoimmune‐induced, alcohol‐induced, metabolic disorder‐induced, causing by apoptosis, and regulating MAPK pathways. These flavonoids may be explored in the future as a therapeutic solution for hepatic diseases.
The student success center network provides national infrastructure for supporting and scaling reform
Authors: Juncos Andrea 
Published: January 2023

AbstractThe Student Success Center Network (SSCN) is dedicated to advancing racial justice and economic mobility by dramatically and equitably increasing the number of students earning postsecondary credentials with labor market value. Managed by Jobs for the Future, the SSCN has worked since 2012 to develop, implement, and scale student success strategies nationally. Each of the 16 statewide Student Success Centers supports community colleges in its state to increase student completion rates, close equity gaps, and strengthen communities. Throughout its history, the SSCN has evolved from a loose association of a few organizations to a powerful “network of networks” that collectively serves over 500 colleges and drives student success reforms, such as Guided Pathways, on a national scale. As the Network grows in size and maturity, it has strengthened its impact as a vehicle for supporting and scaling reform and evolved to meet the changing needs of learners.
Leveraging the coalition of the willing for student success in Michigan
Authors: Schanker Jennifer Ballard , Orians Erica Lee 
Published: January 2023

AbstractThis chapter reflects on how the Michigan Center for Student Success (MCSS) has leveraged its position within a membership organization for community college presidents and trustees to engage in statewide student success efforts in a state with a unique higher education governance structure. With no formal higher education governing body to set policy or coordinate initiatives, the MCSS has relied on individual leaders and practitioners within institutions to create a coalition of the willing who have worked to move the student success agenda forward. The article provides a political and historical context for the center's founding, explores the center's accomplishments, and concludes by discussing considerations for coalition leaders in other states.
Igniting statewide mathematics re‐design: A cross‐sector, grassroots approach
Authors: Henderson Carrie , Ivey Abbey 
Published: January 2023

AbstractMathematics continues to be one of the most significant barriers to student success, particularly in the community college sector. Many students are placed into the algebra‐based track, which is often viewed as the “safe” or most desirable option, when they likely would have been better served in an alternative mathematics pathway more closely aligned to their academic and career goals. However, transformative mathematics re‐design that moves away from the default algebra pathway and traditional content and delivery of instruction is best facilitated by a cross‐sector, faculty‐driven approach to create scalable change to increase student success in mathematics. This chapter highlights the efforts of the Florida Student Success Center in driving statewide mathematics reform and creating distinct statewide mathematics pathways using a grassroots approach driven by experts in the K‐12, college, and university sectors. Practical insight and guidance are provided using Loverme and Kotter's (2019) 8‐Step change process framework.
Differentiation syndrome in patients with acute promyelocytic leukemia
Authors: Elamin Nusiba H. , Rashid Farah , Afana Muhammad S. , Cherif Honar , Yassin Mohamed A. 
Published: January 2023

AbstractA 48‐year‐old male diagnosed with acute promyelocytic leukemia (APL) started on all‐trans‐retinoic acid and arsenic trioxide, developed typical symptoms of differentiation syndrome, and improved dramatically on steroids. Hence, any APL patient started on chemotherapy, needs to be monitored closely for developing differentiation syndrome and to start steroid upon suspicion.
Interhemispheric gravity‐assisted approach for microsurgical resection of a splenium arteriovenous malformation
Authors: Harris Jacob C. , Borja Austin J. , Glauser Gregory , Detchou Donald K. E. , Howard Susanna D. , Choudhri Omar A. 
Published: January 2023

AbstractThe parietal interhemispheric approach employing gravity retraction with skeletonization of bridging veins provides an excellent operative window for safe, curative resection of splenial arteriovenous malformations.
Strain Engineering to Boost Piezocatalytic Activity of BaTiO3
Authors: Ai Jun‐Di , Jin Cheng‐Chao , Liu Dai‐Ming , Zhang Jin‐Tao , Zhang Ling‐Xia 
Published: January 2023

AbstractPiezoelectric materials are sensitive to lattice strain, which is always related with their macroscopic properties. Therefore, it is of scientific significance to improve piezocatalytic performance by strain engineering and clarify the underlying mechanism. Herein, BaTiO3 (BTO) powder is fabricated by a solid‐state reaction and ball‐milling is employed to induce lattice strain in BTO. By prolonging ball‐milling time, the lattice strain increases, leading to an enhancement of tetragonality and piezocatalytic performance of BTO. The strain‐engineered BTO exhibited an excellent piezocatalytic activity, with a degradation rate constant k of ∼0.03 min−1 and a H2 evolution rate of 0.899 mmol g−1 h−1, which are 3 and 3.52 times those of the strain‐free one, respectively. The enhanced piezocatalytic performance can be ascribed to the improved piezoelectricity, piezoelectric polarization and adsorption activities for O2, OH and H of the strain‐engineered BTO. This work not only provides a simple and general method to improve piezocatalytic performance by strain engineering, but also unveils the enhancement mechanism.
CO2 Methanation over Cobalt Nanoparticles Embedded in ZIF‐L–Derived Porous Carbon
Authors: Gholampour Nadia , Zhao Yingrui , Devred François , Sassoye Capucine , Casale Sandra , Debecker Damien P. 
Published: January 2023

AbstractCatalytic hydrogenation of CO2 into CH4 is an effective method to convert waste CO2 and green hydrogen into clean fuel on a large scale. However, the viability of such process largely relies on the development of highly active heterogeneous catalysts. Here, a tailored methanation catalyst, Co nanoparticles immobilized into a highly porous N‐doped carbon matrix, is prepared by the carbonization of a cobalt‐based layered zeolitic imidazolate framework (ZIF−L) material under an argon atmosphere. This catalyst displays a specific activity of 22.3 molCH4/gcat.min at 350 °C, significantly outperforming a similar catalyst derived from the more conventional ZIF‐67 (11.7 molCH4/gcat.min). This is explained by the stabilization of small Co nanoparticles (∼20 nm) and by the presence of abundant medium‐strength basic sites related to the nitrogen doping in the catalyst prepared from ZIF−L. Notably, the new catalyst shows high stability; no deactivation is observed up to 60 hours on stream.