bluuebunny/crossref_metadata_2025_split huggingface dataset:
NECROPOLÍTICA , NECROPODER:FACE A FACE COM A EXISTÊNCIA HUMANA
Authors: Rigatto Mello Nancy , Aparecida Amador Mascia Marcia 
Published: July 2023

A problemática de desigualdades que permeia a sociedade desde a sua formação é representada por um grupo que mantem a normas para manter-se em convivência e é instalado na mentalidade dela todas as condições sobre as quais a grande maioria das pessoas devem viver e morrer. A centralização do poder, com o agravante do racismo, manteve seu espaço garantido na história da educação, privilegiando e excluindo por motivos similares o acesso ao conhecimento, onde a população serve como um objetivo de produção para a manutenção do poder. Enquanto traremos visões sobe a educação como interesse da sociedade, é importante não perdermos a base de uma estrutura que deveria ser, e para isso pretendemos apresentar a necropolítica e o biopoder e seus desdobramentos para pensarmos a educação e a educação a distância(EaD) .
projetos migratórios de Brasileiras/os na Alemanha no século XXI e as configurações de famílias transnacionais
Authors: Assis Gláucia , Alves Isadora , Canella Francisco , Martendal Laís 
Published: July 2023

A emigração de brasileiros para o exterior tem colocado questões significativas para compreendermos a reconstrução das identidades em diferentes contextos, nesse caso pretendemos analisar a intensificação do fluxo de brasileiras para a Alemanha, na segunda década do século XXI. Este artigo busca discutir os percursos migratórios de brasileiras na Alemanha e como se construíram seus projetos migratórios e os laços sociais com o Brasil configurando famílias transnacionais. A pesquisa é de natureza qualitativa e, devido a pandemia COVID-19, as entrevistas foram realizadas mediadas por computadores, de forma que recorremos às plataformas digitais Google Meet, Zoom, Microsoft Teams e Whatsapp. Neste artigo, apresentamos os resultados a partir da seleção de 05 (cinco) entrevistas, de um total de 22 realizadas, que nos possibilitam compreender a configuração de famílias transnacionais e a caracterização desse fluxo em direção à Alemanha, evidenciando as transformações nas relações familiares e de gênero.
Islam and Traditions of The Bugis Pagatan Coastal Community
Authors: Jamalie Zulfa , Wibowo Fasih 
Published: July 2023

This study concerned the relationship between Islam and traditions commonly practiced by the Bugis Pagatan coastal community. The purpose is to sociologically describe religious life and understand various rites due to a mixture of Islam and traditions. It is a descriptive qualitative, and empirical research that combines sociological, anthropological, and historical approaches to analyze the religious life of the Bugis Pagatan community. The results showed that there are three major traditions in the life of the coastal community, namely religious traditions as part of teaching values (mabbarasanji, massukkiri, mappanrelebbe), rites (mappandretasi'), and life cycle (mappabotting, madutta, mapacci, mappenretojang). Each form of tradition contains religious and cultural symbols as well as deep best values. Religious values found covered devotion, sincerity, and patience, to obtain safety and the blessings of life. Meanwhile, cultural and social values were in the form of honesty, openness, strength, chastity, and honor, to maintenance of harmony and togetherness. Thus, the interaction between Islam and local traditions runs in harmony and mutually reinforces. Islamic acculturation is accepted with the implementation of culture and directed to support spreading the religion. This research recommends the importance of maintaining a harmonious relationship between Islam and culture to prevent conflicts. Penelitian ini mengkaji hubungan antara Islam dan tradisi yang biasa dilakukan oleh masyarakat pesisir Bugis Pagatan. Tujuannya untuk mendeskripsikan secara sosiologis kehidupan beragama dan memahami berbagai ritus akibat percampuran antara Islam dan tradisi. Penelitian ini merupakan penelitian deskriptif kualitatif dan empiris yang memadukan pendekatan sosiologis, antropologis, dan historis untuk menganalisis kehidupan keagamaan masyarakat Bugis Pagatan. Hasil penelitian menunjukkan bahwa terdapat tiga tradisi besar dalam kehidupan masyarakat pesisir Bugis Pagatan, yaitu tradisi keagamaan sebagai bagian dari ajaran nilai (mabbarasanji, massukkiri, mappanrelebbe), ritus (mappandretasi'), dan daur hidup (mappabotting, madutta, mapacci, mappenretojang). Setiap bentuk tradisi mengandung simbol-simbol agama dan budaya serta nilai-nilai terbaik yang mendalam. Nilai religius berupa ketaqwaan, keikhlasan, dan kesabaran, untuk memperoleh keselamatan dan keberkahan hidup. Sedangkan nilai budaya dan sosial berupa kejujuran, keterbukaan, kekuatan, kesucian, dan kehormatan, untuk terpeliharanya kerukunan dan kebersamaan. Kesimpulan, interaksi antara Islam dan tradisi lokal berjalan harmonis dan saling menguatkan. Akulturasi Islam diterima dengan implementasi budaya dan diarahkan untuk mendukung proses penyebaran agama. Penelitian ini merekomendasikan pentingnya menjaga hubungan yang harmonis antara Islam dan budaya untuk mencegah terjadinya konflik.
Satria Piningit: The Concept of Leadership Based on Javanese Local Wisdom
Authors: Mulati Yeni , Purwandari Eny 
Published: July 2023

The discourse on Satria Piningit has been regarded only as a mystical prophecy that emerged during the succession of national leadership in Indonesia. Many political figures use Satria Piningit to get the people's support so they can be elected as leaders. It is hoped that this support will emerge; the prediction about Satria Piningit's arrival is a prevalent discourse among the Javanese people. This article aims to conduct a literature study on Satria Piningit's discourse as a leadership regeneration concept based on Javanese local wisdom. It used the systematic literature review method of fifteen articles that discuss Satria Piningit's discourse as a leadership concept. The concept of Satria Piningit is an idea of ideal leadership based on local Javanese wisdom that can be applied at various levels, from small to national leadership. Discourse on Satria Piningit contributed to the formation of nationalism during the Indonesian independence struggle. This discourse is also closely related to religious expression in Indonesia. The Satria Piningit leadership concept can be developed in more detail as a form of regeneration of leaders based on Javanese local wisdom. Wacana Satria Piningit selama ini dianggap hanya sebagai sebuah ramalan bernuansa mistis yang muncul pada suksesi kepemimpinan nasional. Banyak tokoh politik menggunakan istilah Satria Piningit untuk mendapatkan dukungan rakyat hingga bisa terpilih menjadi pemimpin. Dukungan tersebut diharapkan muncul, karena ramalan tentang kedatangan Satria Piningit, merupakan sebuah wacana yang sangat populer di kalangan masyarakat Suku Jawa. Artikel ini bertujuan untuk melakukan kajian literatur tentang wacana Satria Piningit sebagai sebuah konsep kaderisasi kepemimpinan berbasis kearifan lokal Jawa. Artikel ini menggunakan metode systematic literature review dari lima belas artikel yang membahas wacana Satria Piningit sebagai sebuah konsep kepemimpinan. Konsep Satria Piningit merupakan sebuah ide tentang kepemimpinan ideal berbasis kearifan lokal Jawa yang bisa diterapkan di berbagai jenjang, mulai dari kepemimpinan skala kecil hingga nasional. Wacana Satria Piningit memiliki kontribusi terhadap pembentukan karakter nasionalisme di masa perjuangan kemerdekaan RI. Wacana ini juga sangat berkaitan dengan ekspresi keberagamaan di Indonesia. Konsep Kepemimpinan Satria Piningit bisa dikembangkan menjadi lebih rinci sebagai salah satu bentuk kaderisasi pemimpin berbasis kearifan lokal Jawa.
Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells
Authors: Lin Huan-Ting , Takagi Masatoshi , Kubara Kenji , Yamazaki Kazuto , Michikawa Fumiko , Okumura Takashi , Naruto Takuya , Morio Tomohiro , Miyazaki Koji , Taniguchi Hideki , Otsu Makoto 
Published: July 2023

Abstract
Background: Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic RAS impacts non-transformed hematopoietic progenitor cells (HPCs). Such potential pre-malignant status may characterize HPCs in patients with RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). This study sought to elucidate the biological and molecular alterations in human HPCs carrying monoallelic mutant KRAS (G13C) with no other oncogene mutations.
Methods: We utilized induced pluripotent stem cells (iPSCs) derived from two unrelated RALD patients. Isogenic HPC pairs harboring either wild-type KRAS or monoallelic KRAS (G13C) alone obtainedfollowing differentiationenabled reliable comparative analyses. The compound screening was carried out with an established platform using KRAS (G13C) iPSCs and differentiated HPCs.
Results: Cell culture assays revealed that KRAS (G13C) impacted both myeloid differentiation and expansion characteristics of iPSC-derived HPCs. Comprehensive RNA-sequencing analysis depicted close clustering of HPC samples within the isogenic group, warranting comparative studies performed within the same genetic background. When compared with no stimulation, iPSC-derived KRAS(G13C)-HPCs showed marked similarity with the wild-type isogenic control in transcriptomic profiles. After stimulation with cytokines, however, KRAS(G13C)-HPCs exhibited obvious aberrant cell-cycle and apoptosis responses, compatible with “dysregulated expansion,” demonstrated by molecular and biological assessment. Increased BCL-xL expression was identified amongst other molecular changes unique to mutant HPCs. With screening platforms established for therapeutic intervention, we observed selective activity against KRAS (G13C)-HPC expansion in several candidate compounds, most notably in a MEK- and a BCL-2/BCL-xL-inhibitor. These two compounds demonstrated selective inhibitory effects on KRAS (G13C)-HPCs even with primary patient samples when combined.
Conclusions: Our findings indicate that a monoallelic oncogenic KRAS can confer dysregulated expansion characteristics to non-transformed HPCs, which may constitute a pathological condition in RALD hematopoiesis. The use of iPSC-based screening platforms will lead to discovering treatments that enable selective inhibition of RAS-mutated HPC clones.
Multilocal Genotyping of Sugarcane White Leaf phytoplasma in Thailand.
Authors: Watcharachaiyakup Jutatape , Burns Parichart , Chaphakdee Patchara , Boonsonti Wuttitharuk , Saengmanee Pimpilai , Kositratana Wichai 
Published: July 2023

Abstract
Sugarcan white leaf (SCWL) phytoplasma is a pathogen associated with sugarcane white leaf, a severe disease causing yield losses in sugarcane plantations, particularly in Asian countries. In this study, 174 SCWL symptomatic sugarcane samples were collected from sugarcane growing areas in the North, Northeastern and Central plain of Thailand. The genotyping was performed using partial 16s rDNA and partial internal transcribed spacer and multilocus sequence typing (MLST) based on six genes including tuf, secY, leuS, secA, AAA1 and GroES. The analysis indicated that partial 16s rDNA and partial internal transcribed spacer and other six genes could divide SCWL phytoplasma within sugarcane samples into two groups: 16SrXI-B and 16SrXI-D. Sugarcane samples found throughout the country consisted of SCWL phytoplasma in 16SrXI-B group (85.6%) while 16SrXI-D group was only found in the Northeastern regions. It was either found with 16SrXI-B in Roi et, Kalasin and Mookdahan provinces or alone in Surin province. The outcome of MLST offered extensive diversity studies of SCWL phytoplasma in Thailand which further information for disease management, detection method development and monitoring.
Clinical Performance Improved by Near-Peer Education: What a Powerful Tool!
Authors: Alves André S. , Taramarcaz Victor , Cerutti Bernard , Genevay Stéphane , Schiffer Eduardo , Perron Noelle Junod 
Published: July 2023

Abstract
Introduction
Near-Peer education has been shown to be beneficial in medicine. The aim of the study was to create a near-peer led formative objective structured clinical examination (OSCE) and assess its impact on students’ performance.
Method
The formative OSCE consisted of a 2-hour session during which 3rd year students (junior) practiced clinical skills under the supervision of a tutor (4th -6th year medical student). The tutor facilitated a group of three students playing successively the roles of the clinician, the observer or the patient in three situations. Both groups were asked to respond to an online survey evaluating their self-perceptions regarding the usefulness of the OSCE (Likert scale 1–5). Junior students’ scores (0-100) at the summative 3rd year OSCE were collected.
Results
115 junior students (72%) attended the formative OSCE. 26 tutors were recruited for teaching. Response rates to the online survey were respectively 46% and 61%. Junior students considered they improved their clinical history taking (mean = 4.55 (SD 0.64)), physical exam (mean = 4.60 (SD 0.63)) and clinical reasoning skills (mean = 4.60 (SD 0.69)). They valued tutors’ feedback (mean = 4.81(SD 0.82) and facilitation skills (mean = 4.42 (SD 1.02)). Those who participated to the OSCE had higher global scores (mean = 79.00(7.24)) than non-participants (mean = 75.54 (SD 6.11)) at the summative OSCE (p = 0.015). Tutors perceived they improved their clinical skills (mean = 3.98(SD 0.94)) and learned teaching skills (mean = 4.80 (SD 0.41)).
Conclusion
Near-peer OSCE is a valuable way to improve junior students’ clinical skills and their performance at summative OSCEs. It allows senior students to enhance their own clinical skills and develop teaching skills.
Development of a fatty acid metabolism-related genes predictive model in colon cancer patients
Authors: wang xuan , Chen Min , Bai Shuheng , Li Rong , Lan Ning , Li Wenyang , Wu Fang , Liu Wanyi , Hu Fengyuan , Zhang Xiangxiang , yang yiping , gao ying , ren juan 
Published: July 2023

Abstract
Purpose
Colon cancer (CC) is a malignant tumor with high morbidity and mortality. Fatty acid metabolism, has attracted more attention as an essential part of tumor metabolic reprogramming. This study aimed to investigate the relationship between fatty acid metabolism-related genes and clinical survival outcomes in CC.
Method
We downloaded the mRNA expression profiles and clinical information of CC from the TCGA data portal. Expression of fatty acid metabolism-related genes and survival data of CC samples were extracted. Univariate Cox analysis and LASSO regression analysis were used to identify the fatty acid metabolism-related genes correlated with the prognosis of CC patients. Then, those six prognostic fatty acid metabolism-related genes were used to construct a prognostic model to predict the survival probability of CC patients. Patients were divided into two groups at high and low risk, and the differences in GSEA enrichment, drug sensitivity, immune cell infiltration, the efficacy of immunotherapy, and immune checkpoint expression level between the two groups were discussed. Finally, a novel nomogram integrating the risk score, age, gender, and clinical stages was established to predict the prognosis of CC patients. The Nomogram prediction model's accuracy was evaluated by using calibration plots, ROC curve, and DCA.
Result
449 CC and 41 normal samples were included in this study. A prognostic model based on six fatty acid metabolism-related genes was built to evaluate the prognosis of CC patients. Patients in the high-risk group had poorer overall survival than those in the low-risk group (P < 0.001). The expression level of macrophages and T helper cells were higher, and the expression level of Tregs was lower in the high-risk group. The expression levels of PD-1, LAG3, and CTLA4 were higher in high-risk patients, and the high-risk group had a higher TIDE score, indicating a worse response to immunotherapy. The Calibration plots, ROC curve, and DCA have all proved that the Nomogram system can accurately predict the survival rate of CC patients.
Conclusion
Fatty acid metabolism-related genes can be used as a new therapeutic target for CC and further improve the survival rate of CC patients through individualized therapy.
Induced polarization imparts piezoelectricity in non-crystalline polymer films
Authors: Yang Zhengbao , Yan Xiaodong , Li Xuemu , Long Zhihe , Peng Zehua , Fu Jing , Zhang Zhuomin , Liu Shiyuan , Hong Ying , Li Qi , Zhang Shujun , Damjanovic Dragan 
Published: July 2023

Abstract
Piezoelectric materials produce linear deformation in response to an applied electric field and are essential for precision control devices. The conventional view is that polymers must be crystalline and possess a remanent polarization after an artificial poling in order to gain piezoelectricity. For ferroelectric polymer poly(vinylidene difluoride), the required poling field is exceptionally high, up to 150–200 volts per micron. Here, we circumvent this limitation by utilizing the elastic displacement of the electric dipoles and creating a net polarization. In this case, the dielectric acts as a piezoelectric as long as a bias electric field is applied, with its piezoelectric coefficient increasing proportionally to the strength of the electric field until polarization saturation sets in. Experiments indicate that a sub-coercive field of 68 volts per micron can induce a high piezoelectric coefficient d33 of − 36 picometers per volt in an unpoled poly(vinylidene fluoride-trifluoroethylene) film. The proposed methodology is further extended to amorphous polymers, providing an opportunity to discover new piezoelectrics within the dielectric family.
Conservation tillage promotes crop productivity by changing soil aggregation in oasis farming ecosystems
Authors: Han Chenglong , Zhou Weidi , Gu Yanjie , wang junqiang , Zhou Yanfang , Xue Yunyin , Shi Zhigou , Siddique Kadambot H.M. 
Published: July 2023

Abstract
Background Aims
Conservation tillage benefited soil aggregate function—essential for soil nutrient cycling and plant growth. Nevertheless, little is known about tillage practices' impact on soil particle aggregation, particularly soil nutrients and distribution of enzymes and microbes among different-sized aggregates, and their possible later influence upon other soil functions and processes.
Methods
We conducted a long-term experiment with maize (Zea mays L.) in a region of oasis farming in Northwest China, in which tillage was applied in four treatments: no-tillage, minimal tillage, fold-tillage, and sub-tillage. Soil aggregates were categorized as follow: <0.25 mm (‘micro’), 0.25–2 mm (‘small’), and > 2 mm (‘macro’), whose corresponding nutrient contents, enzymatic activity and stoichiometry were measured, as well as the structure of soil microbial community of those fraction, along with crop productivity.
Results
The no-tillage treatment increased the amount of N, P, and C in soil, the biomass of microbiota, and the availability P and N within micro-aggregates and bulk soil. It also augmented enzymatic activity for acquiring C- and P as well the enzymatic ratio of C: N but decreased that of N: P in micro-aggregates, and promoted crop productivity compared with conventional tillage. Additionally, microbial community structure differed under the four tillage regimes and between the aggregate fractions, especially under conventional tillage, but the tillage system did not affect alpha diversity.
Conclusions
Our results showed that no-tillage restructured the soil microbial community composition of aggregate fractions. Thus, long-term conservation tillage promotes soil functioning and crop productivity by changing soil aggregates in oasis farmland ecosystems.
Histidine reduces the risk of diabetic nephropathy in women by affecting tryptophan metabolism: A cross-sectional study in Chinese patients with type 2 diabetes
Authors: luo weiming , xie mingzhe , wang bowen , zhang wei , zheng jun , Fang Zhong-Ze , Zhang Qiang 
Published: July 2023

Abstract
Objective：This study explored the effect of histidine on the occurrence of diabetic nephropathy in different gender populations and it’s specific possible pathway, as well as the influence of Metformin on the pathway.
Methods：This study retrieved 1031 patients with type 2 diabetes mellitus from the First Affiliated Hospital of Liaoning Medical University in Jinzhou, Liaoning Province, China. We used stepwise logistic regression to analyze the association between histidine and diabetic nephropathy in the general population and in gender-stratified populations. And the mediating effect analysis was used to explore the specific pathway of this relationship in the female population.
Results：The protective effect of histidine on diabetic nephropathy was influenced by gender, and it is significant in woman (univariable: OR: 0.68 (95%CI: 0.5,0.93), multivariable: OR: 0.54 (95%CI: 0.38,0.78)). And the specific pathway of its effect was partly through affecting tryptophan metabolism.
Conclusions：The protective effect of histidine against diabetic nephropathy in the female population was stronger than that in the general population, and was negatively affected by Metformin. This helps us pay more attention to the clinical nutritional and preventive value of histidine and tryptophan in female diabetic patients.
Evaluation of Neuroprotective effect of Cassia occidentalis L. against colchicine induced memory impairment in Wistar rats
Authors: Jadhav Devika , Saraswat Nikita , Vyawahare Neeraj , Shirode Devendra 
Published: July 2023

Abstract

Background: Alzheimer’s disease is a progressive neurological disorder that develops with aging.
Objective: In this research, we have examined the anti - Alzheimer’s effect of ethanolic extract from roots of Cassia occidentalis L. on colchicine induced Alzheimer’s in Wistar rats.
Methods: Ethanolic extract was obtained and spectroscopic, chromatography analysis was performed. Acute toxicity studies using OECD Guidelines 423 were performed to examine and make sure that there were no signs of toxic effects. The induction of AD was done using colchicine which leads to symptoms like neurotoxicity, neuroinflammation, and neurodegeneration. Body weight, behavioral parameters, locomotor activity, biochemical evaluation was performed.
Results: Pharmacognostic analysis showed the presence of vascular bundles, starch grains, fibers, calcium oxalate crystals, elongated parenchyma, and collenchyma mucilage. Presence of phytoconstituens as flavonoids, alkaloids, tannins and phenols was detected. Locomotor activity, Escape latency time, Conditioned avoidance response, Transfer latency were improved with treatment. Interleukin- 6 levels were reduced significantly in treatment Group V (739.2±0.37) than in Group - II (850.6±0.40). Tumor necrosis factor (TNF-α) was decreased in Group - V (1030.93±0.00) than in Group - II (1455.06±1.25). A significant decrease in beta-amyloid protein level was observed in Group- II (2.52± 0.10), (3.33±0.90) as compared to Group- V (5.27±0.09), (5.01±0.10) respectively, in the Hippocampus and Entorhinal cortex. Histopathology of the Hippocampus and Entorhinal cortex showed reduced neuroinflammation, diminished amyloid plaques, and neurodegeneration in the treatment groups.
Conclusions: The ethanolic extract from roots of Cassia occidentalis L. improved memory damage, was neuroprotective in Alzheimer’s induced rats. It restored neuronal degeneration in the Hippocampus, and Entorhinal cortex and reduced oxidative stress.