bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug and alcohol intoxication in major trauma: Associations, trends and outcomes over a decade
Authors: Woliansky Jonathan , Gumm Kellie , Clark Nico , Knott Jonathan , Read David J 
Published: May 2023

AbstractObjectivesDrug and alcohol intoxication is common among injured patients altering trauma presentation and characteristics. However, uncertainty exists regarding the effect of intoxication on injury severity, as well as outcomes. The present study aims to provide an update on substance‐use patterns and their association with traumatic presentation and outcome within a contemporary Australian context.MethodsAll major trauma patients captured in our centre's Trauma Registry between July 2010 and June 2020 were included. Demographic, injury characteristic, outcome and substance‐use data were collected. Differences in injury severity and characteristics were explored using χ2 tests, while outcomes were modelled using adjusted binomial logistic regression.ResultsAmong 9700 patients, 9% were drug‐intoxicated prior to injury, while 9.4% were alcohol‐intoxicated. Drug use almost tripled between 2010 (4.8%) and 2020 (13.3%), while alcohol intoxication fell, from 11.7% to 7.3%, over the same period. Although there were significant differences in trauma mechanism among intoxicated patients, group comparison found no difference in Injury Severity Score for any group. Regarding outcomes, all intoxication resulted in significantly greater odds (odds ratio 1.62–2.41) of ICU admission. No difference in mortality was found among individual substance‐use groups; however, polysubstance‐intoxicated patients had 3.52 times greater odds of dying (95% confidence interval 1.21–10.23) compared to non‐intoxicated patients.ConclusionWithin this contemporary Australian population, we demonstrate escalating rates of drug intoxication and declining rates of alcohol intoxication prior to trauma. Intoxication was associated with more frequent violent and non‐accidental injury, and despite no difference in severity, it was associated with worse outcomes.
Enterprise system implementation and cash flow volatility
Authors: Liu Alfred Z. , Pincus Morton , Xu Sean Xin 
Published: May 2023

AbstractThis study investigates the financial and operational implications of enterprise systems (ESs) in corporate risk management. Using matched difference‐in‐differences analyses based on ES implementation events, we document a significant reduction in the volatility of operating cash flows following ES implementations. We further show that ES implementers have better post‐implementation operational efficiency than matched non‐ES firms and better manage sales, costs of sales, working capital, and operating expenses to reduce operating cash flow volatility. Consistent with the benefits of lower cash flow volatility documented in prior literature, we find ES implementers demonstrate higher investment efficiency, lower reliance on external financing, and higher debt capacity post‐ES‐implementation than the matched non‐ES firms. Our study sheds light on the economic benefits of utilizing ESs in corporate risk management and in so doing responds to the paucity of empirical research in this area.
Uncorrected soil water isotopes through cryogenic vacuum distillation may lead to a false estimation on plant water sources
Authors: Yang Bin , Dossa Gbadamassi G. O. , Hu Yue‐Hua , Liu Lu‐Lu , Meng Xian‐Jing , Du Yi‐Yuan , Li Jia‐Yuan , Zhu Xi‐Ai , Zhang Yong‐Jiang , Singh Ashutosh K. , Yuan Xia , Wu Jun‐En , Zakari Sissou , Liu Wen‐Jie , Song Liang 
Published: May 2023

Abstract

Successful use of stable isotopes (δ2H and δ18O) in ecohydrological studies relies on the accurate extraction of unfractionated water from different types of soil samples. Cryogenic vacuum distillation (CVD) is a common laboratory‐based technique used for soil water extraction; however, the reliability of this technique in reflecting soil water δ2H and δ18O is still of concern.

This study examines the reliability of a newly developed automatic cryogenic vacuum distillation (ACVD) system. We further assessed the impacts of extraction parameters (i.e. extraction time, temperature and vacuum) and soil properties on the recovery of soil water δ2H and δ18O for the ACVD and traditional cryogenic vacuum distillation (TCVD) systems. Finally, we investigated the potential influence of CVD (ACVD and TCVD) technique on the prediction of plant water uptake through a sensitivity analysis.

Both ACVD and TCVD similarly extracted water from the rewetted soils, but none of the CVD systems successfully recovered the isotopic signatures of doped water from soil materials. Mean δ2H offsets of extracted soil water were −2.6 ± 1.3‰ and −2.4 ± 1.7‰ for ACVD and TCVD, respectively, while mean δ18O offsets were −0.16 ± 0.14‰ and −0.39 ± 0.37‰. The isotopic offsets of CVD systems were positively correlated with soil clay content, and negatively correlated with soil water content. Using corrected soil data (with CVD offsets) could improve the prediction of plant water uptake based on its high correlation with the environmental factors.

This study identifies the isotopic offsets of CVD systems (i.e. ACVD and TCVD) and provides possible solutions for better predicting plant water sources. Even though, the wide use of CVD techniques probably induce noticeable uncertainties in the prediction of plants water uptake depths. The dataset of soil water extraction in this study will have implications for the technological development of CVD techniques.
How does a family history of psychosis influence the risk of methamphetamine‐related psychotic symptoms: Evidence from longitudinal panel data
Authors: McKetin Rebecca , Clare Philip J. , Castle David , Turner Alyna , Kelly Peter J. , Lubman Dan I. , Arunogiri Shalini , Manning Victoria , Berk Michael 
Published: May 2023

AbstractAimsTo determine whether the risk of psychotic symptoms during weeks of methamphetamine use was dependent on, increased by, or independent of having a family history of psychosis.DesignSecondary analysis of 13 contiguous 1‐week periods of data (1370 weeks). A risk modification framework was used to test each scenario.SettingGeelong, Wollongong and Melbourne, Australia.ParticipantsParticipants in a randomized controlled trial of treatment for methamphetamine dependence (n = 148) who did not have a primary psychotic disorder on enrolment.MeasurementsPsychotic symptoms in the previous week were defined as a score of 3+ on any of the Brief Psychiatric Rating Scale items of hallucinations, unusual thought content or suspiciousness. Any (vs no) methamphetamine use in the previous week was assessed using the Timeline Followback method. Self‐reported family history of psychosis was assessed using the Diagnostic Interview for Psychosis.FindingsThe risk of psychotic symptoms in the past week was independently associated with methamphetamine use in that week (relative risk [RR] = 2.3, 95% CI = 1.3–4.3) and with having a family history of psychosis (RR = 2.4, 95% CI = 0.9–7.0); the joint risk among participants with a family history of psychosis during weeks when they were using methamphetamine was large (RR = 4.0, 95% CI = 2.0–7.9). There was no significant interaction between a family history of psychosis and methamphetamine use in predicting psychotic symptoms (interaction RR = 0.7 95% CI = 0.3–1.8), but there was a small non‐significant excess risk due to the interaction (0.20 95% CI = −1.63 to 2.03).ConclusionsAmong people dependent on methamphetamine, the relative risk of psychotic symptoms during weeks of methamphetamine use does not appear to be dependent on, or increased by, having a family history of psychosis. However, a family history of psychosis does appear to be an independent risk factor that contributes to the absolute risk of psychotic symptoms in this population.
Myeloid‐derived suppressor cells: Are they involved in gestational diabetes mellitus?
Authors: Hua Siyu , Wang Shanshan , Cai Jinyang , Wu Lamei , Cao Yan 
Published: May 2023

AbstractGestational diabetes mellitus (GDM) is currently the most common metabolic complication during pregnancy, with an increasing prevalence worldwide. Maternal immune dysregulation might be partly responsible for the pathophysiology of GDM. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells, emerging as a new immune regulator with potent immunosuppressive capacity. Although the fate and function of these cells were primarily described in pathological conditions such as cancer and infection, accumulating evidences have spotlighted their beneficial roles in homeostasis and physiological conditions. Recently, several studies have explored the roles of MDSCs in the diabetic microenvironment. However, the fate and function of these cells in GDM are still unknown. The current review summarized the existing knowledges about MDSCs and their potential roles in diabetes during pregnancy in an attempt to highlight our current understanding of GDM‐related immune dysregulation and identify areas where further study is required.
Ivabradine in the treatment of non‐paroxysmal junctional tachycardia with interference atrioventricular dissociation: A case report
Authors: Ying Shuo , Zhang Jing , Fu Nai‐kuan , Zhang Peng 
Published: May 2023

AbstractIvabradine reduces the heart rate by selectively inhibiting the If current of the sinoatrial node, mainly for the treatment of chronic heart failure with decreased left ventricular systolic function and inappropriate sinus tachycardia, but the inhibitory effect on the atrioventricular node is rarely reported. The patient was admitted to hospital mainly because of intermittent chest pain for 7 years, which worsened for 10 days. Admission electrocardiogram (ECG) considered sinus tachycardia, with QS wave and T wave inversion in II, III, aVF, V3R‐V5R, V4–V9 leads, and non‐paroxysmal junctional tachycardia (NPJT) with interference atrioventricular dissociation. After treatment with ivabradine the ECG returned to normal conduction sequence. NPJT with interference atrioventricular dissociation is a fairly rare electrocardiographic phenomenon. This case reports for the first time that ivabradine is used in the treatment of NPJT with interference atrioventricular dissociation. It is speculated that ivabradine has a potential inhibitory effect on the atrioventricular node.
Enduring Colonial Grammars of Self: Infrastructure, Coloniality, Ethnicity
Authors: Lesutis Gediminas 
Published: May 2023

AbstractBuilding on critical geographical scholarship on racialism and coloniality reiterated through infrastructure systems, this article explores how inherently colonial constructs of ethnicity‐as‐identity—as sub‐genres of humanity and further biopolitical differentiation of Blackness—are reworked through contemporary mega‐infrastructures. Focusing on the development of Lamu Port in Kenya, it analyses how infrastructures entrench pre‐existing symbolic and material divisions between ostensibly different ethnic groups and how they perceive themselves within Kenya's body politic. Doing this, the article demonstrates how mega‐infrastructures actively reproduce the sub‐genres of humanity that were set in motion during the colonial period as categories inscribing the racialised, constitutive otherness to Whiteness. The coloniality of power, therefore, endures, reverberating through infrastructures into materialities of the present and the everyday of peoples who continue to rely on colonial grammars of sub‐humanisation to maintain a sense of self in the world of not their own making.
Accounting For Digital Assets
Authors: Jackson Andrew B. , Luu Steven 
Published: May 2023

AbstractRecent years have seen developments in distributed ledger technologies, such as blockchain, that have led to significant growth in the number and type of digital assets available. In this article we review the current practice of the small number of firms globally reporting digital assets on their financial statements. We then assess potential treatments under current GAAP, namely as intangibles, inventory or financial instruments. Finally, we provide policy advice to standard setters, with a call to either develop a new stand‐alone standard or to amend the definition of financial instruments to include cryptocurrencies, to allow greater comparability and understandability in firms’ reporting.Recent years have seen significant growth in the number and type of digital assets available. We review the current practices of firms reporting digital assets. We then assess potential treatments under current GAAP. Finally, we provide policy advice to standard setters, with a call to either develop a new stand‐alone standard or to amend the definition of financial instruments.
Outcomes of allogeneic or autologous stem cell transplantation followed by maintenance chemotherapy in adult patient with B‐ALL in CR1 with no detectable minimal residual disease
Authors: Lv Mengnan , Liu Liangyi , He Yi , Yang Donglin , Ma Qiaoling , Pang Aiming , Zhai Weihua , Wei Jialin , Huang Yong , Chen Xin , Zhang Guixin , Feng Sizhou , Han Mingzhe , Jiang Erlie , Zhang Rongli 
Published: May 2023

AbstractAutologous haematopoietic stem cell transplantation (auto‐HSCT) as a treatment for B‐cell acute lymphoblastic leukaemia (B‐ALL) has been rigorously debated in recent years. We retrospectively analysed the outcomes of 355 adult patients with B‐ALL in first complete remission who had received auto‐HSCT or allogeneic HSCT (allo‐HSCT) in our centre. The treatment efficacy was evaluated from a model stratified on the risk classification and minimal residue disease (MRD) status after three chemotherapy cycles. Auto‐HSCT demonstrated comparable 3‐year overall survival (OS) (72.7% vs. 68.5%, p = 0.441) and leukaemia‐free survival rates (62.8% vs. 56.1%, p = 0.383) compared to allo‐HSCT for patients with negative MRD, while the advantage of lower non‐relapse mortality (1.5% vs. 25.1%, p < 0.001) was offset by a higher cumulative incidence of relapse (CIR) rates (35.7% vs. 18.9%, p = 0.018), especially in high‐risk patients. For patients at high risk and with positive MRD, there was a lower trend of 3‐year OS (50.0% vs. 66.0%, p = 0.078) and significantly higher CIR rates (71.4% vs. 39.1%, p = 0.018) in auto‐HSCT. However, no significant interaction was observed in the tests. In conclusion, auto‐HSCT appears to be an attractive treatment for patients with negative MRD after three chemotherapy cycles. For MRD‐positive patients, allo‐HSCT may be a more effective treatment.
The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B‐cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols
Authors: Öfverholm Ingegerd , Rezayee Fatemah , Heyman Mats , Harila Arja , Arvidsson Linda , Schmiegelow Kjeld , Norén‐Nyström Ulrika , Barbany Gisela 
Published: May 2023

SummaryWe investigated 390 paediatric B‐cell precursor acute lymphoblastic leukaemia (BCP‐ALL) patients treated according to NOPHO ALL 2008, regarding copy number alterations (CNA) of eight loci associated with adverse prognosis, including IKZF1. The impact on outcome was investigated for each locus individually, combined as CNA profiles and together with cytogenetic information. The presence of IKZF1 deletion or a poor‐risk CNA profile was associated with poor outcome in the whole cohort. In the standard‐risk group, IKZF1‐deleted cases had an inferior probability of relapse‐free survival (pRFS) (p ≤ 0.001) and overall survival (pOS) (p ≤ 0.001). Additionally, among B‐other patients, IKZF1 deletion correlated with poor pRFS (60% vs. 90%) and pOS (65% vs. 89%). Both IKZF1 deletion and a poor‐risk CNA profile were independent factors for relapse and death in multivariable analyses adjusting for known risk factors including measurable residual disease. Our data indicate that BCP‐ALL patients with high‐risk CNA or IKZF1 deletion have worse prognosis despite otherwise low‐risk features. Conversely, patients with both a good CNA and cytogenetic profile had a superior relapse‐free (p ≤ 0.001) and overall survival (p ≤ 0.001) in the cohort, across all risk groups. Taken together, our findings highlight the potential of CNA assessment to refine stratification in ALL.
Reuniting philosophy and science to advance cancer research
Authors: Pradeu Thomas , Daignan‐Fornier Bertrand , Ewald Andrew , Germain Pierre‐Luc , Okasha Samir , Plutynski Anya , Benzekry Sébastien , Bertolaso Marta , Bissell Mina , Brown Joel S. , Chin‐Yee Benjamin , Chin‐Yee Ian , Clevers Hans , Cognet Laurent , Darrason Marie , Farge Emmanuel , Feunteun Jean , Galon Jérôme , Giroux Elodie , Green Sara , Gross Fridolin , Jaulin Fanny , Knight Rob , Laconi Ezio , Larmonier Nicolas , Maley Carlo , Mantovani Alberto , Moreau Violaine , Nassoy Pierre , Rondeau Elena , Santamaria David , Sawai Catherine M. , Seluanov Andrei , Sepich‐Poore Gregory D. , Sisirak Vanja , Solary Eric , Yvonnet Sarah , Laplane Lucie 
Published: May 2023

ABSTRACTCancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.
Digital technology use and preoccupation with digital technology as predictors of life satisfaction in children
Authors: Topić Marina Kotrla , Brkljačić Tihana , Brajša‐Žganec Andreja 
Published: May 2023

AbstractObjectiveThis research aims to investigate metric characteristics of the digital technology preoccupation scale and the possibility of predicting life satisfaction in children from 8 to 13 years, based on time spent using digital technology and preoccupation with digital technology.MethodParticipants are 1072 children aged 8 to 13 years and their parents who agreed to participate in the study. Using pen and paper questionnaires, children provided data on their life satisfaction and preoccupation with digital technology (DT), and their parents assessed the average time children used DT during a typical day in a week or during the weekend.ResultsDigital technology preoccupation scale showed good metric characteristics with all five items loading on one factor and good reliability. Boys and older children show more preoccupation with digital technology and lower life satisfaction. Also, boys use DT during the weekend longer than girls. After controlling for the effect of age and gender, and duration of DT use, preoccupation with digital technology explained 3% of the variance of life satisfaction. The total model explained 9% of variance.ConclusionFindings from this study show that preoccupation with digital technology is an important factor to be considered concerning children's life satisfaction, beyond the contribution of time spent using DT.
Novel LSS variants in alopecia and intellectual disability syndrome: New case report and clinical spectrum of LSS‐related rare disease traits
Authors: Elbendary Hasnaa M. , Marafi Dana , Saad Ahmed K. , Elhossini Rasha , Duan Ruizhi , Rafat Karima , Jhangiani Shalini N. , Gibbs Richard A. , Pehlivan Davut , Calame Daniel G. , Posey Jennifer E. , Lupski James R. , Zaki Maha S. 
Published: May 2023

AbstractPathogenic biallelic variants in LSS are associated with three Mendelian rare disease traits including congenital cataract type 44, autosomal recessive hypotrichosis type 14, and alopecia‐intellectual disability syndrome type 4 (APMR4). We performed trio research exome sequencing on a family with a four‐year‐old male with global developmental delay, epilepsy and striking alopecia, and identified novel compound heterozygous LSS splice site (c.14+2T>C) and missense (c.1357 G>A; p.V453L) variant alleles. Rare features associated with APMR4 such as cryptorchidism, micropenis, mild cortical brain atrophy and thin corpus callosum were detected. Previously unreported APMR4 findings including cerebellar involvement in the form of unsteady ataxic gait, small vermis with prominent folia, were noted. A review of all reported variants to date in 29 families with LSS‐related phenotypes showed an emerging genotype–phenotype correlation. Our report potentially expands LSS‐related phenotypic spectrum and highlights the importance of performing brain imaging in LSS‐related conditions.
Correlation between scalp high‐frequency oscillations and prognosis in patients with benign epilepsy of childhood with centrotemporal spikes
Authors: Ji Yichen , Zhang Jun , Lu Hongjuan , Yang Haoran , Zhang Xuan , Liu Huixin , Liu Wenjian , Zhou Wei , Zhang Xiaoling , Sun Wei 
Published: May 2023

AbstractAimsThe study aimed to explore whether high‐frequency oscillations (HFOs) can predict seizure risk and atypical manifestations of benign epilepsy of childhood with centrotemporal spikes (BECTS).MethodsWe recruited 60 patients and divided them into three groups: (1) seizure‐free BECTS, (2) active typical BECTS, and (3) active atypical forms of BECTS. Electroencephalogram was used to record the number, location, average amplitude, and duration of spikes, and spike ripples were analyzed using time‐frequency technology. Multivariable logistic regression analysis was used to investigate independent predictive factors for prognosis.ResultsThe number of sleep spike ripples, rather than spikes, was an independent risk factor for the active period of the disease (odds ratio [OR] = 4.714,p = 0.003) and atypical forms of BECTS (OR = 1.455,p = 0.049); the optimal thresholds for the spike ripple rate were >0 (area under the curve [AUC] = 0.885, sensitivity = 96.15%, specificity = 73.33%) and >0.6/min (AUC = 0.936, sensitivity = 84.21%, specificity = 96.15%), respectively. Furthermore, in typical BECTS, the spike ripple rate showed significant negative correlations with time since the last seizure (ρ = −0.409,p = 0.009) and age (ρ = −0.379,p = 0.016), while the spike rate did not.ConclusionSpike ripple was a marker for distinguishing typical and atypical forms of BECTS and reflected the risk of seizure recurrence better than the spike alone. The present findings might assist clinicians in BECTS treatment.