bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening and prenatal diagnosis of survival motor neuron gene deletion in pregnant women in Zhaoqing city, Guangdong Province
Authors: Huang Zhiwei , Yang Qingchan , Ye Jianxiang , Huang Jianxing , Lin Jin , Chen Jing , Liang Zizhao , Cao Zijie 
Published: March 2023

Abstract
Objective
A total of 5,200 pregnant women in Zhaoqing city, Guangdong Province, were screened to identify spinal muscular atrophy (SMA) mutation carriers to guide the prevention of SMA and prevent the birth of children with SMA.

Methods
Exons 7 and 8 (E7 and E8) of the survival motor neuron (SMN) 1 gene were detected in women using real-time fluorescence quantitative polymerase chain reaction. SMN1 and SMN2 copy numbers in those who were initially identified as carriers were verified via targeted region capture and next-generation sequencing. When both partners were identified as carriers, prenatal diagnosis of the fetus was performed.

Results
Among the screened women, 75 SMA carriers (71 cases had both E7 and E8 heterozygous deletions and 4 cases only had an E7 heterozygous deletion) were identified, with a carrier frequency of 1.44% (95% confidence interval: 1.31–1.65%). Three couples where both spouses were identified as SMA carriers, and their three fetuses were subjected to prenatal genetic analysis. Of the three, one had homozygous deletions of E7 and E8 and the other two had heterozygous deletions of E7 and E8. After a detailed prenatal consultation, the former couple decided to terminate the pregnancy.

Conclusion
Through screening and prenatal diagnosis of pregnant women in Zhaoqing city, Guangdong Province, the incidence of SMA can be reduced, prevention of birth defects can be improved, incidence of birth defects can be effectively minimized.
How to accurately preoperative screen nipple-sparing mastectomy candidate—a nomogram for predicting nipple-areola complex involvement risk in breast cancer patients
Authors: Xu Yuanbing , Pan Dai , Liu Yi , Liu Hanzhong , Sun Xing , Zhang Wenjie , Hu Chaohua 
Published: March 2023

Abstract
Background
Nipple-sparing mastectomy (NSM) offers superior cosmetic outcomes and has been gaining wide acceptance. It has always been difficult to objectively quantify the risk of nipple-areola complex involvement (NACi). The goal was to develop a prediction model for clinical application.

Methods
Patients who had a total mastectomy (TM) between January 2016 and January 2020 at a single institute formed the development cohort (n = 578) and those who had NSM + immediate breast reconstruction (IBR) between January 2020 and January 2021 formed the validation cohort (n = 112). The prediction model was developed using univariate and multivariate logistic regression studies. Based on NACi risk variables identified in the development cohort, a nomogram was created and evaluated in the validation cohort. Meanwhile, stratified analysis was performed based on the model’s risk levels and was combined with intraoperative frozen pathology (IFP) to optimize the model.

Results
Tumor central location, clinical tumor size (CTS) > 4.0 cm, tumor-nipple distance (TND) ≤ 1.0 cm, clinical nodal status positive (cN +), and KI-67 ≥ 20% were revealed to be good predictive indicators for NACi. A nomogram based on these major clinicopathologic variables was employed to quantify preoperative NACi risk. The accuracy was verified internally and externally. The diagnostic accuracy of IFP was 92.9%, sensitivity was 64.3%, and specificity was 96.9% in the validation group. Stratified analysis was then performed based on model risk. The diagnostic accuracy rates of IFP and NACiPM in low-risk, intermediate-risk, and high-risk respectively were 96.0%, 93.3%, 83.9%, 61.3%, 66.7%, and 83.3%.

Conclusion
We created a visual nomogram to predict NACi risk in breast cancer patients. The NACiPM can be used to distinguish the low, intermediate, and high risk of NAC before surgery. Combined with IFP, we can develop a decision-making system for the implementation of NSM.
Mobile Robotic Balance Assistant (MRBA): a gait assistive and fall intervention robot for daily living
Authors: Li Lei , Foo Ming Jeat , Chen Jiaye , Tan Kuan Yuee , Cai Jiaying , Swaminathan Rohini , Chua Karen Sui Geok , Wee Seng Kwee , Kuah Christopher Wee Keong , Zhuo Huiting , Ang Wei Tech 
Published: March 2023

Abstract
Background
Aging degrades the balance and locomotion ability due to frailty and pathological conditions. This demands balance rehabilitation and assistive technologies that help the affected population to regain mobility, independence, and improve their quality of life. While many overground gait rehabilitation and assistive robots exist in the market, none are designed to be used at home or in community settings.

Methods
A device named Mobile Robotic Balance Assistant (MRBA) is developed to address this problem. MRBA is a hybrid of a gait assistive robot and a powered wheelchair. When the user is walking around performing activities of daily living, the robot follows the person and provides support at the pelvic area in case of loss of balance. It can also be transformed into a wheelchair if the user wants to sit down or commute. To achieve instability detection, sensory data from the robot are compared with a predefined threshold; a fall is identified if the value exceeds the threshold. The experiments involve both healthy young subjects and an individual with spinal cord injury (SCI). Spatial Parametric Mapping is used to assess the effect of the robot on lower limb joint kinematics during walking. The instability detection algorithm is evaluated by calculating the sensitivity and specificity in identifying normal walking and simulated falls.

Results
When walking with MRBA, the healthy subjects have a lower speed, smaller step length and longer step time. The SCI subject experiences similar changes as well as a decrease in step width that indicates better stability. Both groups of subjects have reduced joint range of motion. By comparing the force sensor measurement with a calibrated threshold, the instability detection algorithm can identify more than 93% of self-induced falls with a false alarm rate of 0%.

Conclusions
While there is still room for improvement in the robot compliance and the instability identification, the study demonstrates the first step in bringing gait assistive technologies into homes. We hope that the robot can encourage the balance-impaired population to engage in more activities of daily living to improve their quality of life. Future research includes recruiting more subjects with balance difficulty to further refine the device functionalities.
Oligonucleotide usage in coronavirus genomes mimics that in exon regions in host genomes
Authors: Iwasaki Yuki , Abe Takashi , Ikemura Toshimichi 
Published: March 2023

AbstractBackgroundViruses use various host factors for their growth, and efficient growth requires efficient use of these factors. Our previous study revealed that the occurrence frequency of oligonucleotides in the influenza virus genome is distinctly different among derived hosts, and the frequency tends to adapt to the host cells in which they grow. We aimed to study the adaptation mechanisms of a zoonotic virus to host cells.MethodsHerein, we compared the frequency of oligonucleotides in the genome of alpha- and betacoronavirus with those in the genomes of humans and bats, which are typical hosts of the viruses.ResultsBy comparing the oligonucleotide frequency in coronaviruses and their host genomes, we found a statistically tested positive correlation between the frequency of coronaviruses and that of the exon regions of the host from which the virus is derived. To examine the characteristics of early-stage changes in the viral genome, which are assumed to accompany the host change from non-humans to humans, we compared the oligonucleotide frequency between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the beginning of the pandemic and the prevalent variants thereafter, and found changes towards the frequency of the host exon regions.ConclusionsIn alpha- and betacoronaviruses, the genome oligonucleotide frequency is thought to change in response to the cellular environment in which the virus is replicating, and actually the frequency has approached the frequency in exon regions in the host.
The efficacy of nalmefene on anesthetic recovery of patients: a study protocol for a multicenter randomized controlled trial
Authors: Ma Xiaowen , Liu Jueying , Tang Ying , Lian Qiueyue , Huai Xiaorong , Liu Wanfeng , Su Diansan 
Published: March 2023

Abstract
Introduction
So far, the recovery quality after general anesthesia is still unsatisfied. Nalmefene is a drug to treat opioid overdose and reverse opioid actions. We aim to investigate the efficacy of nalmefene on optimizing the recovery quality of patients after general anesthesia.

Methods
It is a prospective, placebo-controlled, two-arm parallel groups, multicentre, double-blind, randomized (PPPMDR) clinical trial. The participants (n = 520) will be randomly assigned into two groups. Each patient will receive either: a single dose of nalmefene 0.25 µg/kg in the intervention group, or the same volume of 0.9% NaCl solution in the control group at the end of the surgery. The primary outcome will be the time interval between the end of anaesthesia and recovery endpoints achieved (Aldrete recovery score ≥ 9) in post-anesthesia care unit (PACU). The other variables are the time interval from the end of operation to extubation; Richmond Agitation Sedation Scale (RASS) score at extubation; the time at Montreal Cognitive Assessment Scale (MoCA) orientation score ≥ 5; visual analog scale (VAS) score and adverse effects including postoperative nausea and vomiting (PONV), and pruritus in PACU and 24 h postoperatively.

Analysis
This trial aims to study whether small dose of nalmefene can shorten the time from the end of surgery to Aldrete score ≥ 9 and improve opioid-induced side effects.This trial focuses on providing the reliable clinical evidence for satisfactory quality of recovery.

Ethics and dissemination
This clinical trial has been approved and supported by the ethics committee of the Renji Hospital, Shanghai Jiaotong University, School of Medicine (KY2020-150); Shanghai Tongren Hospital (2021–030-01);The First Affiliated Hospital of Guangxi Medical University (2021–032); and The First Affiliated Hospital of Zhengzhou University(2021-KY-0495–003). Analysis of the study results will be submitted to a peer-reviewed journal for publication.

Trial registration
ClinicalTrials.gov, NCT04713358, Registered on September 23, 2021.
Influence of Aeolian Sand on Capillary Water Absorption of Concrete Under Freeze–Thaw Conditions
Authors: Li Yugen , Zhang Huimei , Chen Shaojie , Wang Hairen , Liu Xiaoyu , Gao Wei 
Published: March 2023

AbstractAeolian sand (AS) can become a green resource for concrete after the reasonable utilization. Study the evolution of AS concrete (ASC) capillary water absorption (CWA) under freeze–thaw (FT) conditions is of great significance for its popularization and application. One-dimensional (1D) CWA test was performed to analyze the effects of AS and freeze–thaw cycling (FTC) on concrete water absorption characteristics. Pore relative saturation (PRS) and pore saturation were defined to reveal the influence mechanism of AS content on concrete water absorption under FT conditions and predict the moisture distribution in damaged ASC combining with the capillary mechanics theory. The results showed that concrete frost resistance increased with increased AS content and the optimal frost resistance achieved with 100% AS replacement despite its low strength. The initial water absorption rate (WAR), pore saturation, and saturation speed of the ASC decreased with increased AS, while the PRS increased with low AS content but decreased with excessive AS. The water absorption depth increased with increased mass and dynamic elastic modulus loss rates. The mechanism regarding why excessive AS improved concrete frost resistance lay in its internal pore structure and large pore ratio, which reduced pore content that can easily absorb water, enclosed a higher volume of air bubbles, and easily formed "air locking," thereby increasing water transmission resistance and forming long transmission paths during the process of CWA.
Prediction of hepatic decompensation and hepatocellular carcinoma after direct-acting antiviral therapy in patients with hepatitis C-related liver cirrhosis: a cohort study
Authors: Marie Mohamad Saeed , Shousha Hend Ibrahim , Abdelrazek Wael , Hassany Mohamad , Dabees Hosam , Abdelghafour Reem , Aboganob Walaa mosaad , Said Mohamed 
Published: March 2023

AbstractAimThis study aimed to evaluate the rate of hepatic decompensation and de novo HCC and identify their independent factors in HCV genotype 4-infected patients with compensated liver cirrhosis following successful direct-acting antiviral (DAA) therapy.MethodsThis prospective cohort study included 1789 patients with HCV genotype 4-related compensated liver cirrhosis who achieved viral eradication after DAAs. Baseline and follow-up clinical, laboratory, albumin-bilirubin score (ALBI), and abdominal ultrasound were recorded to detect hepatic decompensation and de novo HCC. Logistic regression was performed to evaluate the variables associated with decompensation and HCC.ResultsDuring the 24-month period of follow-up, 184 (10.28%) patients developed hepatic decompensation. Ascites was the commonest presentation. Baseline serum albumin, bilirubin, and platelet count were the independent factors associated with hepatic decompensation (P-values 0.022, 0.03, and < 0.001, respectively). A formula was developed for the prediction of decompensation using these 3 factors (AUC: 0.641 at cutoff 0.1098969 with a sensitivity of 59.9% and specificity of 61.7%). Pre-treatment ALBI score could predict decompensation at cutoff value − 2.5184, AUC 0.609, sensitivity 58.3%, and specificity 59.7%. Post-treatment ALBI score could predict hepatic decompensation after DAA therapy at cutoff value − 2.9521, AUC 0.597, sensitivity 48.1%, and specificity 75.5%. Sixteen (0.9%) patients developed de novo HCC. Age (odds ratio: 1.061, 95%, confidence interval: 1–1.126) and male gender (OR 3.450, 95% CI 1.105–10.769) were the independent factors associated with the development of de novo HCC but not the ALBI score.ConclusionBaseline demographic and laboratory data could predict hepatic decompensation and HCC in patients with compensated liver cirrhosis after successful DAA therapy
Ο «κόσμος» ως «τεύχειν»: Ανθρωπολογικές διαστάσεις της σκέψης του Κώστα Παπαϊωάννου
Authors: Πέτσιος Κωνσταντίνος Θ. 
Published: March 2023

Ἐπιδίωξή μας στὴν παρούσα μελέτη εἶναι ἡ ἀνάδειξη τῶν ἐσωτερικῶν νοηματικῶν ἀρθρώσεων τῆς φιλοσοφικῆς σκέψης τοῦ Νεοέλληνα φιλοσόφου Κώστα Παπαϊωάννου, ἀναφορικὰ μὲ τὰ κριτήρια ποὺ μορφοποιοῦν τὴν ἀνθρώπινη πράξη καὶ συγκροτοῦν τὸ πεδίο τοῦ Πολιτικοῦ. Σύμφωνα μὲ τὸν Παπαϊωάννου, ὁ ἀρχαιοελληνικὸς πολιτισμὸς ἑδραζόταν στὴν ἑνότητα ἀνθρώπου-φύσης, μὲ ἀποτέλεσμα ἡ αὐτόβουλη παρουσία τοῦ ἀνθρωπίνου ὑποκειμένου νὰ νοηματοδοτεῖ τὸ «τεύχειν» ὡς ἀέναη δημιουργικὴ καὶ ἐνσυνείδητη παραγωγὴ νοήματος, δηλαδὴ φανέρωση ἀτομικὴ καὶ πραγμάτωση συλλογικὴ στὸ πεδίο τοῦ κοινωνικῶς ὑπάρχειν. Μέσα ἀπὸ τὸ θεωρητικὸ αὐτὸ πρίσμα, εἴμαστε σὲ θέση νὰ κατανοήσουμε τὴν καταλυτικὴ κριτικὴ τοῦ Παπαϊωάννου τόσο στὸν «μηδενισμὸ» ποὺ ἀναδύθηκε στὴν εὐρωπαϊκὴ σκέψη κατὰ τὸν ὕστερο 19οαἰώνα, ὅσο καὶ στὸν σοβιετικὸ μαρξισμό.
Το αίτημα της συμφιλίωσης του Λόγου με την Ύπαρξη. Επιδράσεις του Κ. Jaspers στο έργο του Κ. Παπαϊωάννου
Authors: Βάσση Παναγιώτα 
Published: March 2023

Ένα από τα κομβικά ζητήματα που απασχολούν τον φιλοσοφικό στοχασμό του Παπαϊωάννου είναι η εργαλειοποίηση του Λόγου στη νεωτερική εποχή και η απορρέουσα εξ αυτού συρρίκνωση της Ύπαρξης. Σε αυτό το πλαίσιο, όπου ο άνθρωπος αφενός δεν θεμελιώνει και δεν εξαρτά καμία βεβαιότητα και κανέναν κανόνα από ένα υπερβατικό ον, όπου γκρεμίζονται οι θεολογικές βεβαιότητες του χριστιανικού κόσμου, αλλά ταυτόχρονα δεν μπορούν να επανεπινοηθούν οι βεβαιότητες του αρχαίου ελληνικού κόσμου, το ερώτημα είναι: τι συνέχει πλέον τον κόσμο, ποιο το νόημα της ζωής; Προκειμένου να απαντήσει σε αυτό το ερώτημα, καταφεύγει ο Παπαϊωάννου στη μέριμνα για το Είναι των υπαρξιστών και του Jaspers ειδικότερα. Χάρη σε αυτή τη θεώρηση, θεμελιώθηκε η απόπειρα συμφιλίωσης του Λόγου με την Ύπαρξη και η φιλοσοφία περιέλαβε, ως Philosophia Perennis, τα ζητήματα της θνητότητας, της τραγικότητας, αλλά και της ελευθερίας της ανθρώπινης ύπαρξης —που συνίστανται στο άνοιγμα της ύπαρξης σε αυτό που την υπερβαίνει. Πρόκειται για τη μετάθεση της φιλοσοφίας από το λογικό εγώ του υποκειμένου που φιλοσοφεί στην ύπαρξη ως ολότητα. Στην παρούσα εισήγηση θα αναδείξουμε σε αυτό το ζήτημα τις επιδράσεις του Jaspers στο έργο του Παπαϊωάννου.
Από την επαναστατημένη μάζα στη μαζική δημοκρατία
Authors: Παρούσης Μιχαήλ 
Published: March 2023

Tο έργο του Παπαϊωάννου συμβάλλει αποφασιστικά στη συγκρότηση του γνωστικού αντικειμένου της Σύγχρονης Ελληνικής Φιλοσοφίας. Ο ίδιος εντάσσεται στη μεταπολεμική γενιά των σύγχρονων φιλοσόφων μας, εκείνη που κατ' αρχάς γοητεύτηκε από τον Μαρξισμό ως υλιστική φιλοσοφία, αλλά κατέληξε στην κριτική όχι μόνο του γραφειοκρατικού ολοκληρωτικού σοβιετικού μοντέλου, μα και στην απόρριψη των βασικών θέσεων του ίδιου του Μαρξ. Τόσο ο Καστοριάδης, όσο και ο Παπαϊωάννου, ανανοηματοδοτούν την ιστορική αποτύπωση της κλασικής αρχαιότητας. Ο πρώτος στηρίζει σε αυτήν την αναζήτηση της αυτονομίας, ο δεύτερος τη συγκρότηση της έννοιας της "μάζας", καθώς συνδέει τη θεατροκρατία, ως το ενοποιητικό στοιχείο του Δήμου, με τους θεσμούς της άμεσης δημοκρατίας, για να στηρίξει μια θετική έννοια της μαζικής δημοκρατίας. Αυτή η έννοια αντιπαραβάλλεται με τις αντιλήψεις περί μαζικής κοινωνίας του 19ου και του 20ού αιώνα, από τον Λε Μπόν μέχρι τον Ρωλς και τους κοινοτιστές.
The Value of Social Media Data in Fashion Forecasting
Authors: Fu Youran , Fisher Marshall 
Published: March 2023

Problem definition: How to use social media to predict style color and jeans fit sales for a retailer. Academic/practical relevance: Neither retail practice nor the academic literature provides a method for using social media to predict style color and jeans fit sales for a retailer. We present and validate a systematic approach for doing that. Methodology: Demand forecasting in the fashion industry is challenging due to short product lifetimes, long manufacturing lead times, and constant innovation of fashion products. We investigate the value of social media information for color trends and jeans fit forecasting. We partner with three multinational retailers, two apparel and one footwear, and combine their proprietary data sets with web-crawled publicly available data on Twitter and the Google Search Volume Index. We implement a variety of machine learning models to develop forecasts that can be used in setting the initial shipment quantity for an item, arguably the most important decision for fashion retailers. Results: Our findings show that fine-grained social media information has significant predictive power in forecasting color and fit demands months in advance of the sales season, and therefore greatly helps in making the initial shipment quantity decision. The predictive power of including social media features, measured by the improvement of the out-of-sample mean absolute deviation over current practice ranges from 24% to 57%. Managerial implications: To our knowledge, this study is the first to explore and demonstrate the value of social media information in fashion demand forecasting in a way that is practical and operable for fashion retailers. With consistent results across all three retailers, we demonstrate the robustness of our findings over market and geographic heterogeneity, and different forecast horizons. Moreover, we discuss potential mechanisms that might be driving this significant predictive power. Our results suggest that changes in fashion demand are driven more by “bottom-up” changes in consumer preferences than by “top-down” influence from the fashion industry. Funding: This work was supported by Wharton School Fishman-Davidson Center for Service and Operations Management, the Wharton School Baker Retailing Center, and the Wharton School Risk Management Center Russell Ackoff Doctoral Student Fellowship. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1193 .
Complications following ankle arthroscopy
Authors: Arshad Zaki , Aslam Aiman , Al-shdefat Sofyan , Khan Rahul , Jamil Omar , Bhatia Maneesh 
Published: March 2023

AimsThis systematic review aimed to summarize the full range of complications reported following ankle arthroscopy and the frequency at which they occur.MethodsA computer-based search was performed in PubMed, Embase, Emcare, and ISI Web of Science. Two-stage title/abstract and full-text screening was performed independently by two reviewers. English-language original research studies reporting perioperative complications in a cohort of at least ten patients undergoing ankle arthroscopy were included. Complications were pooled across included studies in order to derive an overall complication rate. Quality assessment was performed using the Oxford Centre for Evidence-Based Medicine levels of evidence classification.ResultsA total of 150 studies describing 7,942 cases of ankle arthroscopy in 7,777 patients were included. The overall pooled complication rate was 325/7,942 (4.09%). The most common complication was neurological injury, accounting for 180/325 (55.4%) of all complications. Of these, 59 (32.7%) affected the superficial peroneal nerve. Overall, 36/180 (20%) of all nerve injuries were permanent. The overall complication rate following anterior ankle arthroscopy was 205/4,709 (4.35%) compared to a rate of 35/528 (6.6%) following posterior arthroscopy. Neurological injury occurred in 52/1,998 (2.6%) of anterior cases using distraction, compared to 59/2,711 (2.2%) in cases with no distraction. The overall rate of major complications was 16/7,942 (0.2%), with the most common major complication – deep vein thrombosis – occurring in five cases.ConclusionThis comprehensive systematic review demonstrates that ankle arthroscopy is a safe procedure with a low overall complication rate. The majority of complications are minor, with potentially life-threatening complications reported in only 0.2% of patients.Cite this article: Bone Joint J 2023;105-B(3):239–246.