bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clavipectoral fascia plane block spread: an anatomical study
Authors: Labandeyra Hipolito , Heredia-Carques Cristina , Campoy José Cros , Váldes-Vilches Luis Fernando , Prats-Galino Alberto , Sala-Blanch Xavier 
Published: September 2023

BackgroundThe clavipectoral fascia plane block (CPB) is a novel anesthetic management strategy proposed by Valdes-Vilches for clavicle fractures. This study aimed to investigate the distribution of the injected solution around the clavicle and the surrounding tissues.MethodsTwelve clavicle samples were acquired from six cadavers. CPB was conducted using a 20 mL solution comprising methylene blue and iodinated contrast agent to improve visibility of the injected substance’s dispersion. Methylene blue spread was assessed through anatomical dissection across distinct planes (subcutaneous, superficial muscular, deep muscular, and periosteal layers of the clavicle) in five cadavers. For the purpose of comparing methylene blue distribution, CT scans were performed on three cadavers.ResultsMethylene blue was detected in the medial, intermediate, and lateral supraclavicular nerves, as well as superficial muscles including the deltoid, trapezius, sternocleidomastoid, and pectoralis major. However, no staining was observed in the deep muscle plane, including the subclavius, pectoralis minor, and clavipectoral fascia (CPF). Anterosuperior periosteum exhibited staining in 54% of surface, while only 4% of the posteroinferior surface. CT images displayed contrast staining in anterosuperior periclavicular region, consistent with observations from sagittal sections and anatomical dissections.ConclusionThe CPB effectively distributes the administered solution in the anterosuperior region of the clavicular periosteum, superficial muscular plane, and supraclavicular nerves. However, it does not affect the posteroinferior region of the clavicular periosteum or the deep muscular plane, including the CPF.
Changes in prevalence ofMycoplasma genitaliummacrolide and fluoroquinolone resistance: notes from a 13-year retrospective survey in Dalarna County, Sweden
Authors: Drud Suhella Tulsiani , Anagrius Carin , Loré Britta , Elfving Karin , Jensen Jørgen Skov 
Published: September 2023

ObjectiveMacrolide and fluoroquinolone resistance inMycoplasma genitalium(MG) is of emerging global concern. Compared with neighbouring countries such as Denmark, Sweden has had lower rates of macrolide resistance while fluoroquinolone resistance rates are less well documented. This study retrospectively examined macrolide, fluoroquinolone and multidrug resistance rates from Dalarna County, Sweden over a 13-year period.MethodsMG-positive samples from 2006 to 2018 from patients examined at the Department of Venereology, Central Hospital, Falun, Sweden were tested by sequencing for macrolide resistance mutations (MRM) and fluoroquinolone resistance-associated mutations (QRAM) in theparCandgyrAsubunit regions. A subset of these samples from 2006 to 2011 have been reported on previously, although only for MRM.ResultsOf 874 samples, 98 (11.2%, 95% CI 9.1% to 13.6%) had mutations associated with resistance to macrolides and 19 of 828 (2.3%, 95% CI 8.9% to 23.1%) to quinolones. Mutations associated with resistance to both drugs were detected in 5 of 828 (0.6%, 95% CI 0.1% to 1.4%) samples overall. A significant positive linear trend (p=0.004) for an increase in the rate of macrolide resistance was observed (from 0% in 2006 to 31% in 2018) while the increase in QRAM from 0% in 2006 to 12.3% in 2018 was not statistically significant.ConclusionsDespite a decrease in macrolide and fluoroquinolone consumption in Sweden, there was an overall increase in MG macrolide, fluoroquinolone and dual resistance from 2006 to 2018, although the difference in fluoroquinolone resistance rates was not statistically significant. In order to maintain comparably low resistance rates, resistance-guided therapy for MG infections will be crucial.
The external time-of-flight wall for CEE experiment
Authors: Wang Botan , Xu Haoqian , Chen Xiaolong , Wang Yi , Han Dong , Zhao Lei , Guo Baohong 
Published: September 2023

AbstractA heavy-ion collision facility called the cooler storage ring (CSR) external-target experiment (CEE) is scheduled in Lanzhou, China. The time measurement of the charged particles at the forward angle will be conducted by the external time-of-flight (eTOF) subsystem, which is built with multigap resistive plate chambers (MRPC). This work describes the tasks, performance criteria, detector layout, and prototype test results while outlining the technical design and development status of the CEE-eTOF wall. The effectiveness of the wall design has been validated using a FairRoot-based simulation, which is an essential part of the verification. With a $$3.2 \times 1.6~\textrm{m}^2$$

3.2
×
1.6

m
2

coverage, a 60 ps overall time resolution, and a 2.6 m distance from the collision point, the eTOF wall enables the particle identification, system triggering, and event selection in cooperation with other related detectors. A novel structure called sealed MRPC will be applied to the subsystem. The design considerations of this type, prototype test, and results are also described in this paper.
A self-gravitating system composed of baryonic and dark matter analysed from the post-Newtonian Boltzmann equations
Authors: Kremer Gilberto M. , Ourabah Kamel 
Published: September 2023

AbstractWe study the Jeans gravitational instability for a mixture of baryonic and dark matter particles, in the post-Newtonian approximation. We adopt a kinetic model consisting of a coupled system of post-Newtonian collisionless Boltzmann equations, for each species, coupled to the post-Newtonian Poisson equations. We derive the stability criterion, accounting for both post-Newtonian corrections and the presence of dark matter. It is shown that both effects give rise to smaller Jeans masses, in comparison with the standard Jeans criterion, meaning that a smaller mass is needed to begin the gravitational collapse. Taking advantage of that, we confront the model with the observational stability of Bok globules, and show that the model correctly reproduces the data.
Advanced Image Processing Techniques for Medical Image Retrieval Using Visual Features and Distance Measures
Authors: Krishnamoorthy Sujatha , Lakshmi S. Venkata , Janet J. , Sundararaj Vinu 
Published: September 2023

Recently, there has been a rapid increase in the volume of medical image repositories because of the maximized utilization of digitized image data in hospitals. As a result, there is a complexity in querying and handling such large databases, which has led to the development of a novel Content-Based Medical Image Retrieval (CBMIR) technique. In this work, the CBMIR technique is developed using three types of visual features (i.e., color, texture and shape) along with 12 distance measures, and is optimized with the Crossover-Gravitational Search Algorithm (CRO-GSA). For ease, we named this technique Content-Based Medical Image Retrieval using Visual features with CRO-GSA (CBMIRVC). The initial step of our CBMIRVC technique is to extract three types of visual features from the images. Then, each type of feature is employed with a suitable distance measure, which is used for the computation of image similarities between the medical images in the database and a provided query image. The optimization of our proposed CBMIRVC technique is done by the CRO-GSA algorithm. This algorithm optimizes the CBMIRVC technique by identifying the optimal combinations of visual features and similarity measures. Additionally, optimal weights are computed in accordance with the three types of features for the three similarities. Experimental validations were done using retrieved cancer-related and endoscopic color images from databases holding numerous image categories. The experimental outcome shows that our proposed CBMIRVC technique outperforms other conventional image retrieval techniques by effectively retrieving similar images from large databases.
User-Aware Rendering: Merging the Strengths of Device- and User-Perspective Rendering in Handheld AR
Authors: Hueber Sebastian , Wilhelm Johannes , Schäfer René , Voelker Simon , Borchers Jan 
Published: September 2023

In handheld AR, users have only a small screen to see the augmented scene, making decisions about scene layout and rendering techniques crucial. Traditional device-perspective rendering (DPR) uses the device camera's full field of view, enabling fast scene exploration, but ignoring what the user sees around the device screen. In contrast, user-perspective rendering (UPR) emulates the feeling of looking through the device like a glass pane, which enhances depth perception, but severely limits the field of view in which virtual objects are displayed, impeding scene exploration and search.
We introduce the notion of User-Aware Rendering. By following the principles of UPR, but pretending the device is larger than it actually is, it combines the strengths of UPR and DPR. We present two studies showing that User-Aware AR imitating a 50% larger device successfully achieves both enhanced depth perception and fast scene exploration in typical search and selection tasks.
Capturing Types
Authors: Boruch-Gruszecki Aleksander , Odersky Martin , Lee Edward , Lhoták Ondřej , Brachthäuser Jonathan 
Published: September 2023

Type systems usually characterize the shape of values but not their free variables. However, many desirable safety properties could be guaranteed if one knew the free variables captured by values. We describe

CC
< :◻

, a calculus where such captured variables are succinctly represented in types, and show it can be used to safely implement effects and effect polymorphism via scoped capabilities. We discuss how the decision to track captured variables guides key aspects of the calculus, and show that

CC
< :◻

admits simple and intuitive types for common data structures and their typical usage patterns. We demonstrate how these ideas can be used to guide the implementation of capture checking in a practical programming language.
Determinants and Outcomes Associated With Skilled Nursing Facility Use After Coronary Artery Bypass Grafting: A Statewide Experience
Authors: Thompson Michael P. , Stewart James W. , Hou Hechuan , Nathan Hari , Pagani Francis D. , DeLucia Alphonse , Theurer Patricia F. , Prager Richard L. , Hawkins Robert B. , Likosky Donald S. 
Published: September 2023

BACKGROUND:
Skilled nursing facility (SNF) care is frequently used after cardiac surgery, but the patterns and determinants of use have not been well understood. The objective of this study was to evaluate determinants and outcomes associated with SNF use after isolated coronary artery bypass grafting.

METHODS:
A retrospective analysis of Medicare Fee-For-Service claims linked to the Society of Thoracic Surgeons clinical data was conducted on isolated coronary artery bypass grafting patients without prior SNF use in Michigan between 2011 and 2019. Descriptive analysis evaluated the frequency, trends, and variation in SNF use across 33 Michigan hospitals. Multivariable mixed-effects regression was used to evaluate patient-level demographic and clinical determinants of SNF use and its effect on short- and long-term outcomes.

RESULTS:

In our sample of 8614 patients, the average age was 73.3 years, 70.5% were male, and 7.7% were listed as non-White race. An SNF was utilized by 1920 (22.3%) patients within 90 days of discharge and varied from 3.2% to 58.3% across the 33 hospitals. Patients using SNFs were more likely to be female, older, non-White, with more comorbidities, worse cardiovascular function, a perioperative morbidity, and longer hospital lengths of stay. Outcomes were significantly worse for SNF users, including more frequent 90-day readmissions and emergency department visits and less use of home health and rehabilitation services. SNF users had higher risk-adjusted hazard of mortality (hazard ratio, 1.41 [95% CI, 1.26–1.57];
P
<0.001) compared with non-SNF users and had 2.7-percentage point higher 5-year mortality rate in a propensity-matched cohort of patients (18.1% versus 15.4%;
P
<0.001).

CONCLUSIONS:
The use of SNF care after isolated coronary artery bypass grafting was frequent and variable across Michigan hospitals and associated with worse risk-adjusted outcomes. Standardization of criteria for SNF use may reduce variability among hospitals and ensure appropriateness of use.
Association of PCSK9 Inhibitor Initiation on Statin Adherence and Discontinuation
Authors: LaFratte Christopher , Peasah Samuel K. , Huang Yan , Hall Deanne , Patel Urvashi , Good Chester B. 
Published: September 2023

Background
PCSK9is (proprotein convertase subtilisin/kexin type 9 inhibitors) are well tolerated, potently lower cholesterol, and decrease cardiovascular events when added to statins. However, statin adherence may decrease after PCSK9i initiation and alter clinical outcomes. We evaluate the association of PCSK9i initiation on statin discontinuation and adherence.

Methods and Results

In this retrospective pre‐post difference‐in‐difference analysis, new PCSK9i claims were propensity matched with statin‐alone users (April 2017–September 2019). The primary outcomes were statin adherence (proportion of days covered) and statin discontinuation (absence of statin coverage for at least 60 days) 12 months following PCSK9i initiation. Secondary outcomes included low‐density lipoprotein cholesterol levels after 1 year. A total of 220 538 statin users and 700 PCSK9i users were identified, from which 178 on PCSK9i were included and matched to 712 on statins alone. At 12 months, mean statin proportion of days covered decreased from 67% to 48% in the PCSK9i group but increased from 68% to 86% in the statin‐alone groups (
P
<0.0001). Statin discontinuation rates increased from 11% to 39% in the PCSK9i group and from 7% to 9% in the statin‐alone group (
P
=0.0041). Patients with low‐density lipoprotein cholesterol <70 mg/dL increased from 5% to 68% with PCSK9i but increased from 16% to 24% with statins alone (
P
<0.0001). Changes in hospitalization rates were similar between both groups during the follow‐up period.

Conclusions
PCSK9i initiation was associated with decreased low‐density lipoprotein cholesterol, higher statin discontinuation, and reduced statin adherence.
Zymosan A Improved Doxorubicin‐Induced Ventricular Remodeling by Evoking Heightened Cardiac Inflammatory Responses and Healing in Mice
Authors: Xu Guiwen , Hao Zhujing , Xiao Wei , Tan Ruopeng , Yuan Mengyang , Xia Yunlong , Liu Yang 
Published: September 2023

Background
Doxorubicin‐induced myocardial injury is reflected by the presence of vacuolization in both clinical and animal models. The lack of scar tissue to replace the vacuolizated cardiomyocytes indicates that insufficient cardiac inflammation and healing occurred following doxorubicin injection. Whether improved macrophage activity by zymosan A (zymosan) ameliorates doxorubicin‐induced ventricular remodeling in mice is unknown.

Methods and Results
Mice were intravenously injected with vehicle or doxorubicin (5 mg/kg per week, 4 weeks), and cardiac structure and function were assessed by echocardiography. Two distinct macrophage subsets in hearts following doxorubicin injection were measured at different time points by flow cytometry. Moreover, cardiomyocyte vacuolization, capillary density, collagen content, and ventricular tensile strength were assessed. The therapeutic effect of zymosan (3 mg/kg, single injection) on doxorubicin‐induced changes in the aforementioned parameters was determined. At the cellular level, the polarization of monocytes to proinflammatory or reparative macrophages were measured, with or without doxorubicin (0.25 and 0.5 μmol/L). Doxorubicin led to less proinflammatory and reparative macrophage infiltration in the heart in the early phase, with decreased cardiac capillary density and collagen III in the chronic phase. In cell culture, doxorubicin (0.5 μmol/L) repressed macrophage transition toward both proinflammatory and reparative subset. Zymosan enhanced both proinflammatory and reparative macrophage infiltration in doxorubicin‐injected hearts, evoking a heightened acute inflammatory response. Zymosan alleviated doxorubicin‐induced cardiomyocyte vacuolization in the chronic phase, in parallel with enhanced collagen content, capillary density, and ventricular tensile strength.

Conclusions
Zymosan improved cardiac healing and ameliorated doxorubicin‐induced ventricular remodeling and dysfunction by activating macrophages at an optimal time.
Multivariate Emulation of Kilometer-Scale Numerical Weather Predictions with Generative Adversarial Networks: A Proof of Concept
Authors: Brochet Clément , Raynaud Laure , Thome Nicolas , Plu Matthieu , Rambour Clément 
Published: September 2023

Abstract
Emulating numerical weather prediction (NWP) model outputs is important to compute large datasets of weather fields in an efficient way. The purpose of the present paper is to investigate the ability of generative adversarial networks (GANs) to emulate distributions of multivariate outputs (10-m wind and 2-m temperature) of a kilometer-scale NWP model. For that purpose, a residual GAN architecture, regularized with spectral normalization, is trained against a kilometer-scale dataset from the AROME Ensemble Prediction System (AROME-EPS). A wide range of metrics is used for quality assessment, including pixelwise and multiscale Earth-mover distances, spectral analysis, and correlation length scales. The use of wavelet-based scattering coefficients as meaningful metrics is also presented. The GAN generates samples with good distribution recovery and good skill in average spectrum reconstruction. Important local weather patterns are reproduced with a high level of detail, while the joint generation of multivariate samples matches the underlying AROME-EPS distribution. The different metrics introduced describe the GAN’s behavior in a complementary manner, highlighting the need to go beyond spectral analysis in generation quality assessment. An ablation study then shows that removing variables from the generation process is globally beneficial, pointing at the GAN limitations to leverage cross-variable correlations. The role of absolute positional bias in the training process is also characterized, explaining both accelerated learning and quality-diversity trade-off in the multivariate emulation. These results open perspectives about the use of GAN to enrich NWP ensemble approaches, provided that the aforementioned positional bias is properly controlled.
Is the Climate of the Congo basin Becoming Less Able to Support a Tropical Forest Ecosystem?
Authors: Vizy Edward K. , Manoj Harisankar , Cook Kerry H. 
Published: September 2023

Abstract
Ongoing degradation of the Congolese rain forest is documented, but the individual roles of climate change and deforestation are unknown. A modified version of the Centro de Previsao de Tempo e Estudios Climaticos (CPTEC) potential vegetation model (PVM) forced by ERA5 reanalysis data translates decadal climate states (1980–2020) into natural vegetation distributions to identify regions where climate change could have played a role in changing vegetation. These areas are then examined to understand how and why these climate changes could affect the tropical rain forest coverage. Between the 1980s and the 2010s, the climate over the northern and southern Congo basin rain forest margins becomes less able to support the forest. In the north, strong, negative meridional moisture gradients in boreal winter separate warm, dry conditions to the north from the cooler, moist rain forest. By the 2010s greenhouse gas warming deepens the low-level trough in the north, enhancing the inflow of drier subtropical air. A similar drying response occurs over the southern margin during austral winter when the low-level westerly transport of Atlantic moisture decreases in association with warming and reduced low-level heights over the equatorial Congo basin. In the interior, climate conditions also become less favorable along major transportation routes by the 2010s due to human intervention/deforestation. Along coastal Angola, the climate becomes more favorable for tropical forest vegetation when coastal upwelling weakens and SSTs warm in response to changes in the South Atlantic subtropical anticyclone. These results have implications for the future as global warming continues.
Atmospheric Flash Drought in the Caribbean
Authors: Ramseyer Craig A. , Miller Paul W. 
Published: September 2023

Abstract
Despite the intensifying interest in flash drought both within the United States and globally, moist tropical landscapes have largely escaped the attention of the flash drought community. Because these ecozones are acclimatized to receiving regular, near-daily precipitation, they are especially vulnerable to rapid-drying events. This is particularly true within the Caribbean Sea basin where numerous small islands lack the surface and groundwater resources to cope with swiftly developing drought conditions. This study fills the tropical flash drought gap by examining the pervasiveness of flash drought across the pan-Caribbean region using a recently proposed criterion based on the evaporative demand drought index (EDDI). The EDDI identifies 46 instances of widespread flash drought “outbreaks” in which significant fractions of the pan-Caribbean encounter rapid drying over 15 days and then maintain this condition for another 15 days. Moreover, a self-organizing maps (SOM) classification reveals a tendency for flash drought to assume recurring typologies concentrated in one of the Central American, South American, or Greater Antilles coastlines, although a simultaneous, Caribbean-wide drought is never observed within the 40-yr (1981–2020) period examined. Furthermore, three of the six flash drought typologies identified by the SOM initiate most often during Phase 2 of the Madden–Julian oscillation. Collectively, these findings motivate the need to more critically examine the transferability of flash drought definitions into the global tropics, particularly for small water-vulnerable islands where even island-wide flash droughts may only occupy a few pixels in most reanalysis datasets.

Significance Statement
The purpose of this study is to understand if flash drought occurs in tropical environments, specifically the Caribbean. Flash droughts represent a quickly evolving drought, which have particularly acute impacts on agriculture and often catch stakeholders by surprise as conditions evolve rapidly from wet to dry conditions. Our results indicate that flash droughts occur with regular periodicity in the Caribbean. Expansive flash droughts tend to occur in coherent subregional clusters. Future studies will further investigate the drivers of these flash droughts to create early warning systems for flash drought.