bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning models combining computed tomography semantic features and selected clinical variables for accurate prediction of the pathological grade of bladder cancer
Authors: Deng Zhikang , Dong Wentao , Xiong Situ , Jin Di , Zhou Hongzhang , Zhang Ling , Xie LiHan , Deng Yaohong , Xu Rong , Fan Bing 
Published: May 2023

ObjectiveThe purpose of this research was to develop a radiomics model that combines several clinical features for preoperative prediction of the pathological grade of bladder cancer (BCa) using non-enhanced computed tomography (NE-CT) scanning images.Materials and methodsThe computed tomography (CT), clinical, and pathological data of 105 BCa patients attending our hospital between January 2017 and August 2022 were retrospectively evaluated. The study cohort comprised 44 low-grade BCa and 61 high-grade BCa patients. The subjects were randomly divided into training (n = 73) and validation (n = 32) cohorts at a ratio of 7:3. Radiomic features were extracted from NE-CT images. A total of 15 representative features were screened using the least absolute shrinkage and selection operator (LASSO) algorithm. Based on these characteristics, six models for predicting BCa pathological grade, including support vector machine (SVM), k-nearest neighbor (KNN), gradient boosting decision tree (GBDT), logical regression (LR), random forest (RF), and extreme gradient boosting (XGBOOST) were constructed. The model combining radiomics score and clinical factors was further constructed. The predictive performance of the models was evaluated based on the area under the receiver operating characteristic (ROC) curve, DeLong test, and decision curve analysis (DCA).ResultsThe selected clinical factors for the model included age and tumor size. LASSO regression analysis identified 15 features most linked to BCa grade, which were included in the machine learning model. The SVM analysis revealed that the highest AUC of the model was 0.842. A nomogram combining the radiomics signature and selected clinical variables showed accurate prediction of the pathological grade of BCa preoperatively. The AUC of the training cohort was 0.919, whereas that of the validation cohort was 0.854. The clinical value of the combined radiomics nomogram was validated using calibration curve and DCA.ConclusionMachine learning models combining CT semantic features and the selected clinical variables can accurately predict the pathological grade of BCa, offering a non-invasive and accurate approach for predicting the pathological grade of BCa preoperatively.
Clinical application of indocyanine green fluorescence imaging navigation for pediatric renal cancer
Authors: Feng Jun , Yang Wei , Qin Hong , Xu Jiatong , Liu Shan , Han Jianyu , Li Ning , He Lejian , Wang Huanmin 
Published: May 2023

BackgroundIndocyanine Green (ICG) fluorescence imaging has been widely used in the surgical treatment of adult renal cancers, but its application in pediatric renal cancers has rarely been reported. This study aims to summarize the experience of ICG fluorescence imaging in pediatric renal cancers and explores its safety and feasibility.MethodsThe clinical features, surgical information, ICG administration regimen, near infrared radiography data in vivo and ex vivo and pathological results of children with renal cancers using ICG navigation were analyzed and summarized.ResultsThere were 7 cases of renal cancer, including 4 cases of Wilms tumor (WT), 1 case of malignant rhabdoid tumor of the kidney (MRTK) and 2 cases of renal cell carcinoma (RCC). By intraoperative intravenous injection of ICG from 2.5 to 5 mg (0.05–0.67 mg/kg), the tumors were visualized in 6 cases in vivo or ex vivo, and the tumor visualization failed in 1 case due to renal artery embolization before operation. By injecting 5 mg ICG into the normal renal tissue during the operation, 3 patients achieved fluorescent localization of sentinel lymph nodes. No ICG-related adverse reactions were found in any of the patients during or after operation.ConclusionsICG fluorescence imaging is safe and feasible for renal cancers in children. Intraoperative administration can achieve tumor and sentinel lymph node visualization which will facilitate the development of nephron sparing surgery (NSS). However, the technique is affected by ICG dose, anatomical conditions around the tumor, and renal blood flow. A proper dose of ICG and the complete removal of perirenal fat are helpful for the fluorescence imaging of the tumor. It has potential in the operation of renal cancer in children.
Hydroxychloroquine and azithromycin alter the contractility of living porcine heart slices
Authors: Wu Qin , Ross Abigail J. , Ipek Tugce , Thompson Georgina H. , Johnson Robert D. , Wu Changhao , Camelliti Patrizia 
Published: May 2023

The cardiotoxicity risk of hydroxychloroquine (HCQ) and azithromycin (AZM) has been the subject of intensive research triggered by safety concerns in COVID-19 patients. HCQ and AZM have been associated with QT interval prolongation and drug-induced arrhythmias, however other cardiotoxicity mechanisms remain largely unexplored. Our group has pioneered the living heart slice preparation, an ex-vivo platform that maintains native cardiac tissue architecture and physiological electrical and contractile properties. Here, we evaluated the cardiotoxic effect of HCQ and AZM applied alone or in combination on cardiac contractility by measuring contractile force and contraction kinetics in heart slices prepared from porcine hearts. Our results show that clinically relevant concentrations of HCQ monotherapy (1–10 µM) reduced contractile force and contraction kinetics in porcine slices in a dose-dependent manner. However, AZM monotherapy decreased contractile force and contraction kinetics only at higher concentrations (30 µM). Combination of HCQ and AZM induced a dose-dependent effect similar to HCQ alone. Furthermore, pre-treating porcine heart slices with the L-type calcium channel agonist Bay K8644 prevented the effect of both drugs, while administration of Bay K8644 after drugs interventions largely reversed the effects, suggesting a mechanism involving inhibition of L-type calcium channels. These findings indicate that HCQ and AZM alter cardiac function beyond QT prolongation with significant contractile dysfunction in intact cardiac tissue. Our porcine heart slices provide a powerful platform to investigate mechanisms of drug cardiotoxicity.
Examining the paradoxical effects of kratom: a narrative inquiry
Authors: Smith Kirsten E. , Feldman Jeffrey D. , Dunn Kelly E. , McCurdy Christopher R. , Weiss Stephanie T. , Grundmann Oliver , Garcia-Romeu Albert , Nichels Janeen , Epstein David H. 
Published: May 2023

Introduction: Surveys and case reports have documented kratom use in the United States (US) for over a decade. However, those reports have generally not examined in depth the role kratom plays in the lives of those who use it regularly for sustained periods. Until there are controlled studies of the pharmacology and subjective effects of kratom alkaloids in humans, one of the best sources of insight on kratom-product use remains qualitative data with nuanced descriptions of kratom effects from those who use it regularly.Method: We conducted semistructured qualitative interviews with adults who regularly use kratom products, as part of a laboratory study of kratom-product self-administration. This qualitative component of the study was conducted as a narrative case-report series (n = 10).Results: Despite some differences among participants, all experienced acute combination effects that were largely, even simultaneously, analgesic and stimulatory. Most participants had decreased their dosages over time, and one planned to quit. Five of the 10 participants met DSM-5-based criteria for kratom-use disorder (3 mild, 1 moderate, 1 severe, by symptoms counts). When kratom was inadvertently taken in larger than intended doses, participants described a constellation of symptoms that they called “the wobbles” (a jittery feeling accompanied by what seemed to be nystagmus); this was rare, but could be of scientific and clinical interest as a possible manifestation of serotonin syndrome. Most participants described tolerance but considered kratom generally safe at low-moderate doses, providing perceived benefits with less potential risk for adverse effects compared to pharmaceuticals or illicit drugs.Discussion: In-depth interview data like these help confirm and clarify findings from larger survey studies and clinician-driven case reports. They are needed to inform the policy practice regarding kratom and may also help inform future experimental designs.
Effects of early adjunctive pharmacotherapy on serum levels of brain injury biomarkers in patients with traumatic brain injury: a systematic review of randomized controlled studies
Authors: Mansour Noha O. , Elnaem Mohamed Hassan , Abdelaziz Doaa H. , Barakat Muna , Dehele Inderpal Singh , Elrggal Mahmoud E. , Abdallah Mahmoud S. 
Published: May 2023

Objectives: Traumatic brain injury (TBI) is one of the top causes of morbidity and mortality worldwide. The review aimed to discuss and summarize the current evidence on the effectiveness of adjuvant neuroprotective treatments in terms of their effect on brain injury biomarkers in TBI patients.Methods: To identify relevant studies, four scholarly databases, including PubMed, Cochrane, Scopus, and Google Scholar, were systematically searched using predefined search terms. English-language randomized controlled clinical trials reporting changes in brain injury biomarkers, namely, neuron-specific enolase (NSE), glial fibrillary acid protein (GFAP), ubiquitin carboxyl-terminal esterase L1 (UCHL1) and/or S100 beta (S100 ß), were included. The methodological quality of the included studies was assessed using the Cochrane risk-of-bias tool.Results: A total of eleven studies with eight different therapeutic options were investigated; of them, tetracyclines, metformin, and memantine were discovered to be promising choices that could improve neurological outcomes in TBI patients. The most utilized serum biomarkers were NSE and S100 ß followed by GFAP, while none of the included studies quantified UCHL1. The heterogeneity in injury severity categories and measurement timing may affect the overall evaluation of the clinical efficacy of potential therapies. Therefore, unified measurement protocols are highly warranted to inform clinical decisions.Conclusion: Few therapeutic options showed promising results as an adjuvant to standard care in patients with TBI. Several considerations for future work must be directed towards standardizing monitoring biomarkers. Investigating the pharmacotherapy effectiveness using a multimodal biomarker panel is needed. Finally, employing stratified randomization in future clinical trials concerning potential confounders, including age, trauma severity levels, and type, is crucial to inform clinical decisions.Clinical Trial Registration: [https://www.crd.york.ac.uk/prospero/dis], identifier [CRD42022316327].
Glucagon-like peptide-1 receptor-agonists treatment for cardio-metabolic parameters in schizophrenia patients: a systematic review and meta-analysis
Authors: Khaity Abdulrhman , Mostafa Al-dardery Nada , Albakri Khaled , Abdelwahab Omar A. , Hefnawy Mahmoud Tarek , Yousef Yaman A. S. , Taha Ruaa E. , Swed Sarya , Hafez Wael , Hurlemann Rene , Elsayed Mohamed E. G. 
Published: May 2023

AimsWe performed this meta-analysis to evaluate the efficacy and safety of glucagon-like peptide-1 receptor-agonists (GLP-1RA) treatment on cardio-metabolic parameters among antipsychotic-treated patients with schizophrenia.MethodsWe searched the Web of Science, Cochrane Central Register of Controlled Trials, PubMed, PsycINFO, and Scopus for relevant Randomized Clinical trials (RCTs) from inception until 1 August 2022. Documents were screened for qualified articles, and all concerned outcomes were pooled as risk ratios (RR) or mean difference (MD) in the meta-analysis models using Review Manager (RevMan version 5.4).ResultsPooling data from 7 RCTs (398 patients) showed that GLP-1 RA was superior to placebo with regard to body weight [MD = - 4.68, 95% CI (-4.90,−4.46), P &lt; 0.00001], waist circumference [MD = - 3.66, 95% CI (-3.89,−3.44), P &lt; 0.00001], body mass index (BMI) [MD = - 1.09, 95% CI (-1.25,−0.93), P &lt; 0.00001], systolic blood pressure (SBP) [MD = - 3.07, 95% CI (-3.61,−2.53), P &lt; 0.00001], and diastolic blood pressure (DBP) [MD = - 2.02, 95% CI (-2.42,−1.62), P &lt; 0.00001]. The total effect did not favor either of the two groups with respect to insulin and respiratory adverse events {[MD = - 0.06, 95% CI (-0.36, 0.24), p = 0.70], [RR = 0.66, 95% CI (0.31, 1.40), p = 0.28]; respectively}.ConclusionOur analysis revealed that GLP-1 RA treatment is safe and effective on cardio-metabolic parameters over control in antipsychotic-treated patients with schizophrenia. Nevertheless, the present evidence is not sufficient to confirm the safety and efficacy of GLP-1RA treatment on insulin and respiratory adverse events. Therefore, further studies are recommended.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022333040.
Clinical implantation of 92 VACStents in the upper gastrointestinal tract of 50 patients—applicability and safety analysis of an innovative endoscopic concept
Authors: Lange J. , Knievel J. , Wichmann D. , Kähler G. , Wiedbrauck F. , Hellmich T. , Kandler M. , Bernhardt J. , Scholz D. , Beyna T. , Hausmann J. , Wedi E. , Ellrichmann M. , Hügle U. , Dormann A. J. , Eisenberger C. F. , Heiss M. M. 
Published: May 2023

IntroductionEndoscopic vacuum therapy (EVT) has emerged as a promising treatment option for upper gastrointestinal wall defects, offering benefits such as evacuation of secretions and removal of wound debris by suction, and reduction and healing of wound cavities to improve clinical outcomes. In contrast, covered stents have a high rate of migration and lack functional drainage, while endoluminal EVT devices obstruct the GI tract. The VACStent is a novel device that combines the benefits of EVT and stent placement. Its design features a fully covered Nitinol-stent within a polyurethane sponge cylinder, enabling EVT while maintaining stent patency.MethodsThis study analyzes the pooled data from three different prospective study cohorts to assess the safe practicality of VACStent placement, complete leak coverage, and effective suction-treatment of esophageal leaks. By pooling the data, the study aims to provide a broader base for analysis.ResultsIn total, trans-nasal derivation of the catheter, suction and drainage of secretion via vacuum pump were performed without any adversity. In the pooled study cohort of 92 VACStent applications, the mean stent indwelling time was 5.2 days (range 2–8 days) without any dislocation of the device. Removal of the VACStent was done without complication, in one case the sponge was lost but subsequently fully preserved. Minor local erosions and bleeding and one subsequent hemostasis were recorded unfrequently during withdrawal of the device (5.4%, 5/92) but no perforation or pressure ulcer. Despite a high heterogeneity regarding primary disease and pretreatments a cure rate of 76% (38/50 patients) could be achieved.DiscussionIn summary, insertion and release procedure was regarded as easy and simple with a low potential of dislocation. The VACStent was well tolerated by the patient while keeping the drainage function of the sponge achieving directly a wound closure by continuous suction and improving the healing process. The implantation of the VACStent provides a promising new procedure for improved clinical treatment in various indications of the upper gastrointestinal wall, which should be validated in larger clinical studies.Clinical Trial Registration: Identifier [DRKS00016048 and NCT04884334].
Acquisition of Freezing Tolerance of Resurrection Species from Gesneriaceae, a Comparative Study
Authors: Mihailova Gergana , Gashi Bekim , Krastev Nikola , Georgieva Katya 
Published: May 2023

Resurrection plants have the unique ability to restore normal physiological activity after desiccation to an air-dry state. In addition to their desiccation tolerance, some of them, such as Haberlea rhodopensis and Ramonda myconi, are also freezing-tolerant species, as they survive subzero temperatures during winter. Here, we compared the response of the photosynthetic apparatus of two other Gesneriaceae species, Ramonda serbica and Ramonda nathaliae, together with H. rhodopensis, to cold and freezing temperatures. The role of some protective proteins in freezing tolerance was also investigated. The water content of leaves was not affected during cold acclimation but exposure of plants to −10 °C induced dehydration of plants. Freezing stress strongly reduced the quantum yield of PSII photochemistry (Y(II)) and stomatal conductance (gs) on the abaxial leaf side. In addition, the decreased ratio of Fv/Fm suggested photoinhibition or sustained quenching. Freezing-induced desiccation resulted in the inhibition of PSII activity, which was accompanied by increased thermal energy dissipation. In addition, an increase of dehydrins and ELIPs was detected, but the protein pattern differed between species. During recovery, the protein abundance decreased and plants completely recovered their photosynthetic activity. Thus, our results showed that R. serbica, R. nathaliae, and H. rhodopensis survive freezing stress due to some resurrection-linked traits and confirmed their freezing tolerance.
Fine Resolution Classification of New Ice, Young Ice, and First-Year Ice Based on Feature Selection from Gaofen-3 Quad-Polarization SAR
Authors: Yang Kun , Li Haiyan , Perrie William , Scharien Randall Kenneth , Wu Jin , Zhang Menghao , Xu Fan 
Published: May 2023

A new method of sea ice classification based on feature selection from Gaofen-3 polarimetric Synthetic Aperture Radar (SAR) observations was proposed. The new approach classifies sea ice into four categories: open water (OW), new ice (NI), young ice (YI), and first-year ice (FYI). Seventy parameters that have previously been applied to sea ice studies were re-examined for sea ice classification in the Okhotsk Sea near the melting point on 28 February 2020. The ‘separability index (SI)’ was used for the selection of optimal features for sea ice classification. Full polarization parameters (the backscatter intensity contains the horizontal transmit-receive intensity (σhh0), Shannon entropy (SEi), the spherical scattering component of Krogager decomposition (Ks)), and hybrid polarization parameters (horizontal receive intensity(σrh0), hybrid-pol Shannon entropy (CPSEi), the correlation coefficient (ρrh−rv) between the σrh0 and σrv0, and the surface scattering component of m − α decomposition αs) were determined as the optimal parameters for the different work modes of SAR. The selected parameters were used to classify sea ice by the random forest classifier (RFC), and classification results were validated by manually interpreted ice maps derived from Landsat-8 data. The classification accuracy of OW, NI, YI and FYI reached 95%, 96%, 98% and 85%, respectively.
Geographical Information System (GIS)-Based Landslide Susceptibility Mapping in Malaysia: A Review of Past, Current and Future Trends
Authors: Murthy Tharshini , Yusoff Izham Mohamad , Samsudin Siti Hamsah , Majid Taksiah A. , Abir Ismail Ahmad , Yong Chan Huah , Ismail Mohd Ashraf Mohamad 
Published: May 2023

Landslides are very serious natural disasters that cause much damage and threaten human lives. Landslide susceptibility mapping studies are very common in landslide assessments. Geographic information systems (GISs) have been widely used in many fields, especially in landslide studies. This paper provides a review of GIS-based landslide susceptibility mapping in Malaysia from 2000 to 2022 and analyses the number of publications, study areas involved, parameters and models applied in this field over the past 22 years. The number of publications based on the topic shows an increasing trend, with an average of 2 articles published every year. This paper focused on Malaysia’s territory only. The study areas involved in landslide susceptibility studies are Penang, Perak, Selangor, Sabah, Sarawak, Pahang, Kelantan and Kuala Lumpur. Pahang is the study area of the most articles (10), followed by Penang (8). Moreover, 21 parameters were identified, and the slope was the most used parameter (33 articles). Twenty-five models were used, and logistic regression was the most used model, followed by the frequency ratio, ANN and weighted overlay methods.

Received: 24 January 2023 / Accepted: 22 April 2023 / Published: 5 May 2023
« Notre-Taxe de Paris », dépenses fiscales avec deux biens publics
Authors: Rueda Valeria , Wilemme Guillaume 
Published: May 2023

Cet article présente un nouvel arbitrage entre efficience et équité consécutivement aux déductions d’impôt sur les dons privés pour un bien public, lorsqu’il y a plusieurs biens publics. La déduction d’impôt permet de lever efficacement des fonds publics mais elle peut aussi altérer la part relative des biens publics. Nous déterminons la condition pour qu’une déduction plus généreuse soit efficiente au sens de Pareto, condition pour que l’arbitrage disparaisse. Enfin, nous établissons la formule qui fixe le taux de déduction d’impôt optimal . Classification JEL : H21, H23, H41.
The role of miR-143-3p/FNDC1 axis on the progression of non-small cell lung cancer
Authors: Ma Zhanshu , Gao Qi , Xin Wenjing , Wang Lei , Chen Yan , Su Chang , Gao Songyan , Sun Ruiling 
Published: May 2023

The study aimed to explore the functional role of fibronectin type III domain containing 1 (FNDC1) in nonsmall cell lung cancer (NSCLC), as well as the mechanism governing its expression. The expression levels of FNDC1 and related genes in tissue and cell samples were detected by qRT-PCR. Kaplan-Meier analysis was employed to analyze the association between FNDC1 level and the overall survival of NSCLC patients. Functional experiments such as CCK-8 proliferation, colony formation, EDU staining, migration and invasion assays were conducted to investigate the functional role of FNDC1 in regulating the malignancy of NSCLC cells. Bioinformatic tools and dual-luciferase reporter assay were used to identify the miRNA regulator of FNDC1 in NSCLC cells. Our data revealed the upregulation of FNDC1 at mRNA and protein levels in NSCLC tumor tissues cancer cell lines, compared with normal counterparts. NSCLC patients with higher FNDC1 expression suffered from a poorer overall survival. FNDC1 knockdown significantly suppressed the proliferation, migration and invasion of NSCLC cells, and had an inhibitory effect on tube formation. We further demonstrated that miR-143-3p was an upstream regulator of FNDC1 and miR-143-3p expression was repressed in NSCLC samples. Similar to FNDC1 knockdown, miR-143-3p overexpression inhibited the growth, migration and invasion of NSCLC cells. FNDC1 overexpression could partially rescue the effect of miR-143-3p overexpression. FNDC1 silencing also suppressed the tumorigenesis of NSCLC cells in mouse model. In conclusion, FNDC1 promotes the malignant prototypes of NSCLC cells. miR-143-3p is a negative regulator of FNDC1 in NSCLC cells, which may serve as a promising therapeutic target in NSCLC.