bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of and Approach to Taking a History of Exposures to Occupational Respiratory Hazards
Authors: Weissman David N. , Radonovich Lewis J. 
Published: April 2023

AbstractOccupational respiratory diseases are caused by exposure to respiratory hazards at work. It is important to document those exposures and whether they are causing or exacerbating disease because these determinations can have important impacts on diagnosis, treatment, job restrictions, and eligibility for benefits. Without investigation, it is easy to miss clinically relevant exposures, especially in those with chronic diseases that can have work and nonwork causes. The first and most important step in identifying exposures to respiratory hazards at work is to take an appropriate history. For efficiency, this is a two-step process. An initial quick screening history is done by asking only a few questions. Follow-up questions are asked if there are positive responses to the screening questions or if an occupational etiology is suspected based on the clinical presentation. Electronic health records have promise for facilitating this process. Follow-up to the screening history may include additional questions, evaluating additional sources of information about workplace exposures, and medical testing. Radiographic findings or tests conducted on noninvasive samples or lung tissue can be used as biomarkers. Online resources can be used to learn more about exposures associated with occupations and industries and to see if investigations evaluating exposures were performed in the patient's own workplace. It is important to adhere to the patient's wishes about contacting the employer. With patient consent, the employer can be an important source of information about exposures and, if a problem exists, has an important role in taking corrective action. Consultation for challenging cases is available from a variety of professional and governmental entities. If a clinician identifies a significant public health issue, such as an occupational disease outbreak, it is important to notify relevant public health authorities so that steps can be taken to prevent additional exposures and appropriately care for those already exposed.
Evaluation of Changes in Leukocyte Surface Markers in the Early Diagnosis of Late-Onset Neonatal Sepsis
Authors: Korkmaz Seven Efsun , Aydemir Cumhur , Tekin Ishak Ozel 
Published: April 2023

Abstract
Objective This study aimed to evaluate the cluster of differentiation (CD)64, CD16, CD11b, CD63 human leukocyte antigen-DR (HLA-DR), and CD62L leukocyte surface marker abnormalities using flow cytometry in the early diagnosis of late-onset neonatal sepsis.
Methods Forty-four neonates were included in this study. Of them, 22 neonates with clinical late-onset neonatal sepsis were included in the study group, and the remaining 22 neonates without sepsis were considered the control group. Complete sepsis screening was performed. Additionally, monocyte and neutrophil surfaces marker were examined using flow cytometry.
Results The expression of the leukocyte surface markers CD16 and CD64 on monocytes and neutrophils was significantly higher in the study group than in the control group (p < 0.05), while the CD63, CD62L, CD11b, and HLA-DR levels were similar to those in the control group (p > 0.05). Furthermore, receiver operating characteristic curve analysis indicated that neutrophil CD64 (nCD64) is a diagnostic marker for neonatal sepsis, with an area under the curve of 0.901. The CD64 and CD16, which are the respective leukocyte surface markers on neutrophils and monocytes, are useful tests in the early diagnosis of late-onset neonatal sepsis.
Conclusion In addition to acute phase proteins, cell surface antigens such as CD16 and more specifically CD64 should be used in routine investigations for the early diagnosis of late-onset neonatal sepsis. Such use in combination with acute phase reactants can improve diagnostic accuracy.
Collostructional analysis on Chinese modal verb construction neng bu neng + VP
Authors: Shan Weijia , Lin Zhengjun 
Published: April 2023

Abstract
This paper aims to investigate the meanings of Chinese neng (modal verb) bu
(negative word) neng (modal verb) + VP construction and explores the meaning motivations behind them. The present
paper employs the method of collostructional analysis, R software and BLCU Corpus Center1
(BCC) are used to process the linguistic data. It is found that the prototypical meaning of the target construction is “let
something (not) happen or let someone (not) do something” with the sense of negotiation and interaction and its extensional
meanings include “getting an expected result”, “continuation”, “obtaining”, “specific actions containing causation, motion,
communication, vision, life, and mental activities”. The meaning motivations of the construction lie in the force experience of
human from his/her interaction with the outside world, and in the semantic interaction of its constituent words
neng and bu.
Energy resolution of the LZ detector for high-energy electronic recoils
Authors: Pereira G. , Silva C. , Solovov V.N. 
Published: April 2023

Abstract
The LUX-ZEPLIN (LZ) detector is a dual-phase liquid xenon time projection chamber (TPC) installed at the Sanford Underground Research Facility (Lead, South Dakota) at a depth of 1478 meters. Although the main objective of LZ is the direct detection of dark matter, its low background environment allows for the search of other rare processes, such as the neutrinoless double beta decay of xenon isotopes 134Xe and 136Xe with the respective Q-values of 826 keV and 2458 keV. The sensitivity of the detector to these decays is directly determined by the energy resolution, which, in turn, is degraded by non-uniformities in detector response. In this work, we present a novel method to correct, in the data, the non-uniformity of the light collected by an array of photosensors in a scintillation detector. This method is based on the knowledge of the light response functions of individual photosensors. With these techniques, we report, at a very early phase of the detector operations, a state-of-the-art energy resolution (σ/μ) of (0.67 ± 0.01)% at 2614 keV for the fiducial volume of 5.6 tonnes of liquid xenon.
Surface plasmon enhanced fluorescence: self-consistent classical treatment in the quasi-static limit
Authors: Genov Dentcho A 
Published: April 2023

Abstract
The problem of enhanced molecular emission in close proximity to dielectric and metallic interfaces is of great importance for many physical and biological applications. Here we present an exact treatment of the problem from the view point of classical electromagnetism. Self-consistent analytical theory of the surface enhanced fluorescence (SEF) is developed for configurations consisting of an emitter in proximity to core–shell metal-dielectric nanoparticles. The dependence of the fluorescence enhancement on the excitation laser and fluorescence frequencies and distance of the emitter to the nanoparticle interface are studied. The developed theory predicts enhanced fluorescence at intermediate distances as well as emission quenching into non-radiative surface plasmon (SP) modes dominating the response for short distances. The conditions for optimal emission enhancement for two core–shell configurations are determined and a comparison to published experimental data is performed showing a good correspondence between theory and experiment. The developed model can be applied toward analyzes and optimizations of various applications related to SP enhance fluorescence spectroscopy.
A Reexamination ofIn Vitro Fertilization
Authors: Muñoz Michael G 
Published: April 2023

AbstractFor the sake of consistency with settled principles from other theological and ethical questions, there is a need for a Christian reexamination of in vitro fertilization (IVF). Both Old and New Testaments demonstrate that human personal life begins at conception or fertilization. Additionally, the Bible teaches that human beings are persons in the image of God from the very beginning of their existence. Thus, it can be concluded that the embryos created via IVF are persons in God’s image. Applying this to the destruction and freezing of embryos, several limitations or restrictions present themselves—embryos should not be purposefully destroyed or wasted, all embryos ought to be implanted, and embryos should not be frozen. Ultimately, however, due to the immense quantity of embryo wastage, it is concluded that Christians should avoid this form of assisted reproductive technology and consider it a pro-life issue.
Kidney injury molecule 1 (KIM-1): a potential biomarker of acute kidney injury and tubulointerstitial injury in patients with ANCA-glomerulonephritis
Authors: Brilland Benoît , Boud'hors Charlotte , Wacrenier Samuel , Blanchard Simon , Cayon Jérôme , Blanchet Odile , Piccoli Giorgina Barbara , Henry Nicolas , Djema Assia , Coindre Jean-Philippe , Jeannin Pascale , Delneste Yves , Copin Marie-Christine , Augusto Jean-François 
Published: April 2023

ABSTRACT

Background
Kidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein expressed by proximal tubular cells, recognized as an early, sensitive and specific urinary biomarker for kidney injury. Blood KIM-1 was recently associated with the severity of acute and chronic kidney damage but its value in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis with glomerulonephritis (ANCA-GN) has not been studied. Thus, we analyzed its expression at ANCA-GN diagnosis and its relationship with clinical presentation, kidney histopathology and early outcomes.

Methods
We assessed KIM-1 levels and other pro-inflammatory molecules (C-reactive protein, interleukin-6, tumor necrosis factor α, monocyte chemoattractant protein-1 and pentraxin 3) at ANCA-GN diagnosis and after 6 months in patients included in the Maine-Anjou registry, which gathers data patients from four French Nephrology Centers diagnosed since January 2000.

Results
Blood KIM-1 levels were assessed in 54 patients. Levels were elevated at diagnosis and decreased after induction remission therapy. KIM-1 was associated with the severity of renal injury at diagnosis and the need for kidney replacement therapy. In opposition to other pro-inflammatory molecules, KIM-1 correlated with the amount of acute tubular necrosis and interstitial fibrosis/tubular atrophy (IF/TA) on kidney biopsy, but not with interstitial infiltrate or with glomerular involvement. In multivariable analysis, elevated KIM-1 predicted initial estimated glomerular filtration rate (β = –19, 95% CI –31, –7.6, P = .002).

Conclusion
KIM-1 appears as a potential biomarker for acute kidney injury and for tubulointerstitial injury in ANCA-GN. Whether KIM-1 is only a surrogate marker or is a key immune player in ANCA-GN pathogenesis remain to be determined.
Intra-cardiac tumour and bicuspid aortic valve in a patient with neurofibromatosis type 1—rare associations: a case report
Authors: MacLeod Claire , Mangion Kenneth , Roditi Giles , Ahmad Faheem 
Published: April 2023

Abstract

Background
Neurofibromatosis (NF) is an autosomal dominant neurocutaneous disease with multi-system involvement. Three cardiovascular associations are recognized but infrequently reported: congenital heart disease, vasculopathy, and hypertension. Cardiac outflow tract pathology, pulmonary stenosis, and aortic co-arctation have been described in the literature with varying frequency. The incidence of intra-cardiac tumour is exceeding rare.

Case summary
A 53-year-old man presented to the neurosurgical team with myelopathy secondary to cord compression arising from multiple cervical neurofibromas secondary to NF-1. Further cardiac evaluation with echocardiography and cardiac MRI uncovered the presence of both a bicuspid aortic valve (with mild aortic stenosis and moderate aortic regurgitation) and a concurrent intra-cardiac tumour of the mitral papillary muscle; a combined finding which was not reported previously. Serial evaluation confirmed stable disease with no major progression over time.

Discussion
Our case highlights the importance of recognizing cardiovascular manifestations of NF-1 and instituting appropriate screening and surveillance strategies. Targeted non-invasive imaging strategies may be more suited for this purpose over routine clinical examination alone.
Ulster Unionist Political Thought in the Era of the Northern Ireland Troubles, 1968–1998
Authors: Corthorn Paul 
Published: April 2023

Abstract
This article examines Ulster Unionist political thought, in its widest sense, against the backdrop of the Northern Ireland Troubles. During this period, Ulster Unionists sought to resist nationalist and republican arguments for the unification of Ireland and to articulate their position to supporters and wider audiences. As Direct Rule from London followed the suspension of the unionist-dominated Northern Ireland parliament at Stormont in 1972 and its abolition the following year, internal unionist debate intensified over the constitutional future of Northern Ireland. Defining Ulster Unionism broadly, at a time when its organisational forms were proliferating, the article considers the Ulster Unionist Party and its offshoot Vanguard, as well as the Democratic Unionist Party and the paramilitary organisations, the Ulster Volunteer Force and the Ulster Defence Association, and their affiliated political bodies. The article analyses, in turn, the four competing unionist visions of the future: a return to majority-rule devolution; independence; closer integration with Great Britain; and power-sharing devolution. Not attempting a detailed consideration of the policy proposals, the article instead explores the connections forged between Ulster Unionist political ideas, some of them of long pedigree, and wider debates. It shows that, at a time of considerable change for the United Kingdom, Ulster Unionist argument reflected—much more than is currently understood, and sometimes in a pronounced form—a wide range of interconnected contemporary British disputes. These not only concerned the constitution, nationality and sovereignty, but also permissiveness, political parties, decline, the end of empire, Thatcherism and European integration.
Genotypic Diversity of Childhood Rhinovirus Infections
Authors: Schmit Kathryn M , DeMuri Gregory P , Eickhoff Jens C , Bochkov Yury , Gern James E , Wald Ellen R 
Published: April 2023

Abstract
Our objective was to describe the distribution of rhinovirus (RV) by species and type in both symptomatic and asymptomatic children in a prospective study over multiple years. A large and diverse distribution of RV types was seen among children with and without symptoms. RV-A and RV-C were predominant at all visits.
Case report: a rare case of gastroduodenal intussusception caused by GIST in an elderly patient and literature review
Authors: Singh Khushboo , Hlayhel Ahmad , Kulkarni Sayali , Christian Derick 
Published: April 2023

AbstractGastroduodenal intussusception is a rare phenomenon in adults and is caused by gastrointestinal stromal tumors (GIST) in the majority of the documented cases. It commonly presents with abdominal pain, vomiting and melena. GIST is the most common gastrointestinal mesenchymal tumor in gastric and non-gastric locations. It is characterized classically by KIT or PGDFRA expression, and immunohistochemical analysis is the mainstay of diagnosis. Surgical resection provides definitive treatment in 70% of the cases. Here, we present a rare case of gastroduodenal intussusception caused by GIST in an elderly patient.
An Exploration of Accessibility to Trauma-Focused Education and Knowledge Among Music Therapists
Authors: Beach Christopher 
Published: April 2023

Abstract
A substantial number of children and adults in American society have been exposed to violence, marginalization, prejudice, or other traumatic experiences. Thus, it is imperative that those in helping professions have adequate training and resources to recognize and respond to the signs, symptoms, and risks of trauma. Like other helping professionals, music therapists are increasingly called to recognize the impact trauma can have on the communities they serve, but little is known about music therapists’ knowledge and awareness of trauma concepts. A survey was distributed to all board-certified music therapists in the United States that sought to examine the accessibility of educational and professional trainings related to trauma, as well as self-perceived competency in working with service users who have experienced trauma. Of the 8,602 emails distributed (CBMT), 958 different responses were returned, 945 of which consented to participate for a 10.9% response rate. Results indicated a substantial interest in trauma work among music therapists (88.04%); however, almost half of respondents (48.86%) have indicated a lack of access to these trainings for any given reason, leading to limited self-perceived competency in trauma work. This limitation in self-perceived competency in trauma work might exist due to a lack of consistent education and training provided to music therapists, regardless of the mode of education. By not addressing this gap in the profession, harm might be done to those who utilize music therapy services. A breakdown of conglomerate music therapist trauma-specific knowledge is provided, along with identified areas of trauma-concept interest.
Patient and Process Outcomes among Pediatric Patients Undergoing Appendectomy during the COVID-19 Pandemic: An International Retrospective Cohort Study
Authors: Matava Clyde T. , Tighe Nathaniel T. G. , Baertschiger Reto , Wilder Robert T. , Correll Lynnie , Staffa Steven J. , Zurakowski David , Kato Meredith A. , Meier Petra M. , Raman Vidya , Reddy Srijaya K. , Roque Remigio A. , Peterson Melissa Brooks , Zhong John , Edala Thejovathi , Greer Timothy J. , von Ungern-Sternberg Britta S. , Cravero Joseph , Simpao Allan F. ,   for the PEACOC Collaborators
Published: April 2023

Background
COVID-19 forced healthcare systems to make unprecedented changes in clinical care processes. The authors hypothesized that the COVID-19 pandemic adversely impacted timely access to care, perioperative processes, and clinical outcomes for pediatric patients undergoing primary appendectomy.

Methods
A retrospective, international, multicenter study was conducted using matched cohorts within participating centers of the international PEdiatric Anesthesia COVID-19 Collaborative (PEACOC). Patients younger than 18 yr old were matched using age, American Society of Anesthesiologists Physical Status, and sex. The primary outcome was the difference in hospital length of stay of patients undergoing primary appendectomy during a 2-month period early in the COVID-19 pandemic (April to May 2020) compared with prepandemic (April to May 2019). Secondary outcomes included time to appendectomy and the incidence of complicated appendicitis.

Results
A total of 3,351 cases from 28 institutions were available with 1,684 cases in the prepandemic cohort matched to 1,618 in the pandemic cohort. Hospital length of stay was statistically significantly different between the two groups: 29 h (interquartile range: 18 to 79) in the pandemic cohort versus 28 h (interquartile range: 18 to 67) in the prepandemic cohort (adjusted coefficient, 1 [95% CI, 0.39 to 1.61]; P < 0.001), but this difference was small. Eight centers demonstrated a statistically significantly longer hospital length of stay in the pandemic period than in the prepandemic period, while 13 were shorter and 7 did not observe a statistically significant difference. During the pandemic period, there was a greater occurrence of complicated appendicitis, prepandemic 313 (18.6%) versus pandemic 389 (24.1%), an absolute difference of 5.5% (adjusted odds ratio, 1.32 [95% CI, 1.1 to 1.59]; P = 0.003). Preoperative SARS-CoV-2 testing was associated with significantly longer time-to-appendectomy, 720 min (interquartile range: 430 to 1,112) with testing versus 414 min (interquartile range: 231 to 770) without testing, adjusted coefficient, 306 min (95% CI, 241 to 371; P < 0.001), and longer hospital length of stay, 31 h (interquartile range: 20 to 83) with testing versus 24 h (interquartile range: 14 to 68) without testing, adjusted coefficient, 7.0 (95% CI, 2.7 to 11.3; P = 0.002).

Conclusions
For children undergoing appendectomy, the COVID-19 pandemic did not significantly impact hospital length of stay.

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New
The Response of the Infant to the Father's Voice
Authors: Jasin Lisa R. , Newnam Katherine M. 
Published: April 2023

Background:
Premature infants are at increased risk for language delays. The auditory system hears sounds at 25 weeks' gestation; therefore, infants in the neonatal intensive care unit (NICU) may miss crucial language exposure during the period when neural pathways for language processing are developing. Supporting the synergistic relationship between fathers and newborns promotes connections through early language to strengthen engagement and promote infant neurodevelopment.

Purpose:
To determine what is known about preterm infants' response to the male voice.

Data Sources:
Three databases and forward searching of reference lists were used to locate articles addressing the clinical question: “What strategies can be used in the NICU to support purposeful language development?”

Study Selection:
Empiric, primary research studies were included if they were published in English without date restriction.

Data Extraction:
The authors evaluated each study's quality using a validated 16-item assessment tool (QATSDD) developed for studies with diverse designs; data were extracted and organized following Garrard's Matrix Method.

Results:
The aim of this evidence-based review is to report the way an infant responds to the paternal voice. Findings promote a better understanding of individual infant response to paternal voice, including conversational turns and engagement behaviors. Although informative, this review highlights a clear gap in the evidence, supporting standardized methodology.

Implications for Practice and Research:
Fathers should be encouraged to communicate vocally early and often to facilitate bonding in the NICU. Encouraged future study of father–infant communication to support bonding, relationship building, and neurodevelopmental outcomes is paramount.