bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicenter study of artificial intelligence-aided software for detecting visible clinically significant prostate cancer on mpMRI
Authors: Sun Zhaonan , Wang Kexin , Kong Zixuan , Xing Zhangli , Chen Yuntian , Luo Ning , Yu Yang , Song Bin , Wu Pengsheng , Wang Xiangpeng , Zhang Xiaodong , Wang Xiaoying 
Published: April 2023

Abstract
Background
AI-based software may improve the performance of radiologists when detecting clinically significant prostate cancer (csPCa). This study aims to compare the performance of radiologists in detecting MRI-visible csPCa on MRI with and without AI-based software.

Materials and methods
In total, 480 multiparametric MRI (mpMRI) images were retrospectively collected from eleven different MR devices, with 349 csPCa lesions in 180 (37.5%) cases. The csPCa areas were annotated based on pathology. Sixteen radiologists from four hospitals participated in reading. Each radiologist was randomly assigned to 30 cases and diagnosed twice. Half cases were interpreted without AI, and the other half were interpreted with AI. After four weeks, the cases were read again in switched mode. The mean diagnostic performance was compared using sensitivity and specificity on lesion level and patient level. The median reading time and diagnostic confidence were assessed.

Results
On lesion level, AI-aided improved the sensitivity from 40.1% to 59.0% (18.9% increased; 95% confidence interval (CI) [11.5, 26.1]; p < .001). On patient level, AI-aided improved the specificity from 57.7 to 71.7% (14.0% increase, 95% CI [6.4, 21.4]; p < .001) while preserving the sensitivity (88.3% vs. 93.9%, p = 0.06). AI-aided reduced the median reading time of one case by 56.3% from 423 to 185 s (238-s decrease, 95% CI [219, 260]; p < .001), and the median diagnostic confidence score was increased by 10.3% from 3.9 to 4.3 (0.4-score increase, 95% CI [0.3, 0.5]; p < .001).

Conclusions
AI software improves the performance of radiologists by reducing false positive detection of prostate cancer patients and also improving reading times and diagnostic confidence.

Clinical relevance statement
This study involves the process of data collection, randomization and crossover reading procedure.

Graphical Abstract
Meningitis caused by Chromobacterium haemolyticum suspected to be derived from a canal in Japan: a case report
Authors: Iwamoto Kumi , Yamamoto Masaki , Yamamoto Atsushi , Sai Toshi , Mukai Toshiko , Miura Noriko , Kozono Haruhisa , Onishi Shigeki , Ohno Seiko , Iwamoto Nobuki , Matsumura Yasufumi , Nagao Miki , Urata Yoji 
Published: April 2023

Abstract
Background
The genus Chromobacterium, of which 12 species have been recognized, comprises bacteria that reside in tropical and subtropical environments. Of these species, Chromobacterium violaceum and Chromobacterium haemolyticum are known to cause infections in humans. There have been few reports of infections caused by Chromobacterium haemolyticum.

Case presentation
Chromobacterium haemolyticum was detected in spinal fluid and blood samples isolated from a 73-year-old Japanese male patient who fell into a canal in Kyoto City, Japan and developed bacteremia and meningitis. Although meropenem and vancomycin were administered, this patient died 9 days after admission. Although the infection was misidentified as being caused by Chromobacterium violaceum by conventional identification methods, average nucleotide identity analysis revealed that the causative pathogen was Chromobacterium haemolyticum. The same bacteria were also detected in the canal in which the accident occurred. Phylogenetic analysis of the strain isolated from the patient and the strain isolated from the canal suggested that the two strains were very closely related.

Conclusions
Chromobacterium haemolyticum can be misidentified as Chromobacterium violaceum by conventional identification methods and tends to be more resistant to β-lactams than Chromobacterium violaceum. Pigment production and β-hemolysis on blood sheep agar can provide clues for the early identification of Chromobacterium haemolyticum.
Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury
Authors: Fu Zhangning , Zhang Yifan , Geng Xiaodong , Chi Kun , Liu Chao , Song Chengcheng , Cai Guangyan , Chen Xiangmei , Hong Quan 
Published: April 2023

AbstractConsidering the high prevalence and the lack of targeted pharmacological management of acute kidney injury (AKI), the search for new therapeutic approaches for it is in urgent demand. Mesenchymal stem cells (MSCs) have been increasingly recognized as a promising candidate for the treatment of AKI. However, clinical translation of MSCs-based therapies is hindered due to the poor retention and survival rates as well as the impaired paracrine ability of MSCs post-delivery. To address these issues, a series of strategies including local administration, three-dimensional culture, and preconditioning have been applied. Owing to the emergence and development of these novel biotechnologies, the effectiveness of MSCs in experimental AKI models is greatly improved. Here, we summarize the different approaches suggested to optimize the efficacy of MSCs therapy, aiming at promoting the therapeutic effects of MSCs on AKI patients.
Preliminary feasibility of integrating tobacco treatment into SUD peer recovery coaching: a mixed-methods study of peer recovery coaches
Authors: Streck Joanna M. , Regan Susan , Werner Michael , Glynn Alexia , Villanti Andrea C. , Park Elyse R. , Wakeman Sarah E. , Evins A. Eden , Rigotti Nancy A. 
Published: April 2023

Abstract
Background
Individuals with substance use disorder (SUD) have high prevalence of cigarette smoking and difficulty quitting. Peer recovery coaches (PRCs; individuals with lived SUD experience) facilitate SUD behavior change in recoverees but it is unknown if/how they address tobacco treatment in SUD recovery coaching. We assessed PRC’s tobacco-related practices and attitudes about tobacco treatment in SUD recovery.

Methods
The Tobacco use In Peer-recovery Study (TIPS) was a cross-sectional mixed-methods pilot survey (January–March 2022) of the 26 PRCs employed by a Massachusetts-based healthcare system’s 12 SUD treatment clinics/programs. PRCs completed a quantitative survey (n = 23/26; 88%) and a telephone-based qualitative interview (n = 20/26; 77%).

Results
One-third of PRCs reported current smoking, 50% reported former smoking, and 18% never smoked. Among PRCs, 61% reported accompanying recoverees outdoors to smoke, 26% smoked with recoverees, 17% had provided cigarettes to recoverees, 32% used smoking to help build peer-relationships, and 74% rated smoking as socially acceptable in SUD treatment. PRCs reported regularly talking to recoverees about tobacco treatment (65%), believed they should have a role in helping recoverees quit smoking (52%), and were interested in tobacco treatment training (65%). A majority of both nonsmoking and current smoking PRCs (73% vs. 57%) regularly talked to recoverees about quitting smoking.

Conclusion
PRCs’ attitudes about integrating tobacco treatment into SUD recovery coaching were generally positive and PRCs reported they could have a role in helping recoverees with tobacco treatment. Barriers to integrating tobacco treatment into SUD recovery include use of cigarettes as a peer-recovery tool and high prevalence and social acceptability of smoking in SUD recovery.
A qualitative study on the perception of infection prevention and control measures among healthcare workers without patient contact during the SARS-CoV-2 pandemic
Authors: Ehrenzeller Selina , Kuehl Richard , Durovic Ana , Martinez Aurélien Emmanuel , Battegay Manuel , von Rotz Matthias , Fringer André , Tschudin-Sutter Sarah 
Published: April 2023

AbstractWe conducted a qualitative interview-based study to examine the perception of infection prevention and control (IPC) measures implemented during the COVID-19 pandemic among healthcare workers (HCWs) without patient contact in a tertiary academic care center. We compared these findings to those derived from interviews of HCWs with patient contact from the same institution using the same study design. The following main four themes were identified: (1) As for HCWs with patient contact, transparent communication strongly contributes to employees’ sense of security. (2) Information on personal protective equipment (PPE) usage needs to be stratified according to different educational backgrounds and professions. (3) Consistency of IPC measures was positively perceived yet a desire for constant reminders to counteract the fatigue effect played a more significant role for HCWs without patient contact. (4) As compared to HCWs with patient contact, HCWs without patient contact preferred uniform digital training resources rather than more face-to-face training. This study shows that the needs of HCWs with and without patient contact differ and need to be considered in pandemic management.
Variation of the Hydraulic Conductivity and the Mechanical Characteristics of Plastic Concrete with Time
Authors: Basha Ali , Mansour Walid 
Published: April 2023

AbstractSand-bentonite-cement are commonly used as cut-off walls to isolate polluted soils or in ground improvement technologies and as retaining structures as secant pile wall. In this research, a laboratory program consisted from 105 sample were prepared and tested between different tests, such as hydraulic conductivity, porosity, and compressive strength to monitor the mechanical behavior of sand-bentonite-cement at different ages. Based on the experimental relationships between hydraulic conductivity coefficient and samples age; there were reduction due to added bentonite to mixture reach about 35.0% at 7 days. Moreover, the average reduction in the compressive strength of plastic concrete samples with bentonite was lower by average range about 51.0% than the compressive strength of plastic concrete samples without bentonite at 7 days. In this study, proposed formulas were derived to estimate the splitting tensile strength based on the compressive strength and the hydraulic conductivity in terms of the bentonite/cement ratio and testing age. The predicted values showed well agreement with the experimental records for samples of sand-bentonite-cement mixtures where the standard deviation and coefficient of variation were 0.02, and 0.94%, respectively.
Songbirds initiate migratory flights synchronously relative to civil dusk
Authors: Cooper Nathan W. , Dossman Bryant C. , Berrigan Lucas E. , Brown J. Morgan , Brunner Alicia R. , Chmura Helen E. , Cormier Dominic A. , Bégin-Marchand Camille , Rodewald Amanda D. , Taylor Philip D. , Tonra Christopher M. , Tremblay Junior A. , Marra Peter P. 
Published: April 2023

AbstractBackgroundEach spring and fall billions of songbirds depart on nocturnal migrations across the globe. Theory suggests that songbirds should depart on migration shortly after sunset to maximize their potential for nightly flight duration or to time departure with the emergence of celestial cues needed for orientation and navigation. Although captive studies have found that songbirds depart during a narrow window of time after sunset, observational studies have found that wild birds depart later and more asynchronously relative to sunset than predicted.MethodsWe used coded radio tags and automated radio-telemetry to estimate the time that nearly 400 individuals from nine songbird species departed their breeding or wintering grounds across North America. We also assessed whether each species was most likely beginning long-distance migratory flights at departure or instead first making non-migratory regional flights. We then explored variation in nocturnal departure time by post-departure movement type, species, age, sex, and season.ResultsWe found that 90% of individuals from species that were likely initiating long-distance migratory flights departed within 69 min of civil dusk, regardless of species, season, age, or sex. By contrast, species that likely first made non-migratory regional movements away from the migratory destination departed later and more asynchronously throughout the night. Regardless of post-departure movement type, 98% of individuals departed after civil dusk but otherwise showed no preference in relation to twilight phase.ConclusionsAlthough the presence of celestial orientation cues at civil dusk may set a starting point for departure each night, the fact that species likely beginning long-distance migration departed earlier and more synchronously relative to civil dusk than those first making non-migratory regional movements is consistent with the hypothesis that departing promptly after civil dusk functions to maximize the potential for nightly flight duration and distance. By studying the onset of migration, our study provides baseline information about departure decisions that may enhance our understanding of departure timing throughout migration.
Quantification of the effect of gas–water–equilibria on carbonate precipitation
Authors: Zacherl Lilly , Baumann Thomas 
Published: April 2023

AbstractThe expanding geothermal energy sector still faces performance issues due to scalings in pipes and surface level installations, which require elevated operation pressure levels and costly maintenance. For facilities in the North Alpine Foreland Basin, the precipitation of $${\hbox {CaCO}}_{3}$$

CaCO
3

is the main problem which is a consequence of the disruption of the lime-carbonic acid equilibrium during production. The formation of gas bubbles plays a key role in the scaling process. This work presents experiments in a bubble column to quantify the effects of gas stripping on carbonate precipitation and an extension of PhreeqC to include kinetic exchange between a gas phase and water for the simulation of the experimental results. With the same hybrid model not only precipitation of $${\hbox {CaCO}}_{3}$$

CaCO
3

but also the dissolution of scalings by the injection of $${\hbox {CO}}_{2}$$

CO
2

could be quantified. The bubble column was filled with tap water and brine. By varying the ionic strength of the solution, a wider range of geothermal waters was covered. Air and $${\hbox {CO}}_{2}$$

CO
2

were introduced at the bottom. The precipitates built on the column wall were analyzed with Raman spectroscopy: injecting air into tap water at low ionic strength led to the formation of aragonite with 59.8% of the precipitates remaining at the column wall and the rest as particles in dispersion. At moderate ionic strength the dominant polymorph was calcite and 81.5% of the crystals were attached to the wall. At high ionic strength precipitation was inhibited. The presence of crystallization nuclei reduced the time for precipitation, but not the amount of scalings formed. Injecting $${\hbox {CO}}_{2}$$

CO
2

into the solution completely removed the scalings from the column wall. The model and its experimental backup lay the foundation for a process-based prediction of the scales (not only) in geothermal systems.
Applications of remote epitaxy and van der Waals epitaxy
Authors: Roh Ilpyo , Goh Seok Hyeon , Meng Yuan , Kim Justin S. , Han Sangmoon , Xu Zhihao , Lee Han Eol , Kim Yeongin , Bae Sang-Hoon 
Published: April 2023

AbstractEpitaxy technology produces high-quality material building blocks that underpin various fields of applications. However, fundamental limitations exist for conventional epitaxy, such as the lattice matching constraints that have greatly narrowed down the choices of available epitaxial material combinations. Recent emerging epitaxy techniques such as remote and van der Waals epitaxy have shown exciting perspectives to overcome these limitations and provide freestanding nanomembranes for massive novel applications. Here, we review the mechanism and fundamentals for van der Waals and remote epitaxy to produce freestanding nanomembranes. Key benefits that are exclusive to these two growth strategies are comprehensively summarized. A number of original applications have also been discussed, highlighting the advantages of these freestanding films-based designs. Finally, we discuss the current limitations with possible solutions and potential future directions towards nanomembranes-based advanced heterogeneous integration.
Graphical Abstract
A technical note on autologous iliac crest bone grafting for restoration of the distal tibial articular surface
Authors: Hasan Bahaa Zakarya , Mesregah Mohamed Kamal 
Published: April 2023

AbstractPurposeThis technical note describes a reconstructive technique of the distal tibial articular surface using autologous iliac crest bone graft.MethodsFollowing curettage and high‐speed burring of giant cell tumor of bone (GCTB) of the distal tibial articular surface, the resulting cavity was filled, and the articular surface was reconstructed using autologous tricortical iliac crest bone graft. The graft was fixed to the tibia with a plate.ResultsThe smooth congruent articulating surface of the distal tibia was restored. Full ankle range of motion was achieved. No recurrence was detected in the follow‐up imaging.ConclusionsThe currently reported technique using autologous tricortical iliac crest bone graft is a viable option for reconstructing the articular surface of the distal tibia.
Current advances for omics-guided process optimization of microbial manufacturing
Authors: Wan Shengtong , Liu Xin , Sun Wentao , Lv Bo , Li Chun 
Published: April 2023

AbstractCurrently, microbial manufacturing is widely used in various fields, such as food, medicine and energy, for its advantages of greenness and sustainable development. Process optimization is the committed step enabling the commercialization of microbial manufacturing products. However, the present optimization processes mainly rely on experience or trial-and-error method ignoring the intrinsic connection between cellular physiological requirement and production performance, so in many cases the productivity of microbial manufacturing could not been fully exploited at economically feasible cost. Recently, the rapid development of omics technologies facilitates the comprehensive analysis of microbial metabolism and fermentation performance from multi-levels of molecules, cells and microenvironment. The use of omics technologies makes the process optimization more explicit, boosting microbial manufacturing performance and bringing significant economic benefits and social value. In this paper, the traditional and omics technologies-guided process optimization of microbial manufacturing are systematically reviewed, and the future trend of process optimization is prospected.
Drug interactions between ALK inhibitors and warfarin with concurrent use of bucolome: a case report
Authors: Kato Takashi , Kunimoto Yusuke , Kitagawa Manabu , Asai Yuichiro , Kimyo Tomoko , Nakata Hiromasa , Takahashi Mamoru , Chiba Hirofumi , Takahashi Hiroki , Miyamoto Atsushi , Fukudo Masahide 
Published: April 2023

Abstract
Background
Alectinib, crizotinib, and ceritinib, are anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) that exhibit high protein binding, and their metabolism is associated with the cytochrome P450 (CYP) isoenzymes 2C9 or 3A4. The plasma protein binding rate of warfarin, which is used to prevent and treat venous thromboembolism, is also high. Warfarin is a racemate of S-warfarin and R-warfarin, which are metabolized by CYP2C9 and CYP3A4, respectively. Reports on the drug interactions between each of the above-mentioned ALK-TKIs and warfarin with concurrent use of bucolome are currently lacking.
Case presentation.
We report a case of a patient receiving warfarin and bucolome, whose international normalized ratio (INR) increased after sequential treatment with alectinib, crizotinib, and ceritinib. The patient was a 61-year-old man with a history of aortic valve regurgitation, who was receiving warfarin treatment following aortic valve replacement. Bucolome, which can enhance the effect of warfarin, was also used simultaneously. The patient was diagnosed with primary lung adenocarcinoma, and ALK rearrangement was detected during second-line chemotherapy. After progression of the disease with chemotherapy, sequential treatment with alectinib, crizotinib, and ceritinib was initiated. Pretreatment INR values were in the therapeutic range (target INR of 2–3) but increased to supratherapeutic levels each time after initiation of alectinib, crizotinib, or ceritinib treatment. Adjustment of warfarin dose or discontinuation of bucolome were necessary to maintain the therapeutic INR range. There were no serious bleeding events or substantial changes in dietary intake.
Displacement of plasma protein binding or competitive inhibition of metabolism by alectinib, crizotinib, and ceritinib could increase the plasma concentration of the unbound form of warfarin, resulting in high INR values. In addition, alectinib, crizotinib, and ceritinib might cause displacement of bucolome from plasma proteins, followed by displacement of warfarin or inhibition of warfarin metabolism caused by the unbound form of bucolome.

Conclusions
Close monitoring of INR and adjustment of warfarin dosage are needed during treatment with alectinib, crizotinib, or ceritinib in patients who receive warfarin with concurrent use of bucolome.
Historical perspective and recent progress in cardiac ion channelopathies research and clinical practice in Hong Kong
Authors: Leung Keith Sai Kit , Huang Helen , Chung Cheuk To , Radford Danny , Lakhani Ishan , Li Christien Ka Hou , Li Tommy Wai Kei , Ranjithkumar Simon , Rajan Rajesh , Roever Leonardo , Garcia-Zamora Sebastian , Bazoukis George , Liu Tong 
Published: April 2023

AbstractCardiac ion channelopathies encompass a set of inherited or acquired conditions that are due to dysfunction in ion channels or their associated proteins, typically in the presence of structurally normal hearts. They are associated with the development of ventricular arrhythmias and sudden cardiac death. The aim of this review is to provide a historical perspective and recent advances in the research of the cardiac ion channelopathies, Brugada syndrome, long QT syndrome and catecholaminergic polymorphic ventricular tachycardia, in Hong Kong, China. In particular, recent works on the development of novel predictive models incorporating machine learning techniques to improve risk stratification are outlined. The availability of linked records of affected patients with good longitudinal data in the public sector, together with multidisciplinary collaborations, implies that ion channelopathy research efforts have advanced significantly.