bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identified and potential internalization signals involved in trafficking and regulation of Na+/K+ ATPase activity
Authors: Hodeify Rawad , Kreydiyyeh Sawsan , Zaid Leen Mohammad Jamal 
Published: August 2023

AbstractThe sodium–potassium pump (NKA) or Na+/K+ ATPase consumes around 30–40% of the total energy expenditure of the animal cell on the generation of the sodium and potassium electrochemical gradients that regulate various electrolyte and nutrient transport processes. The vital role of this protein entails proper spatial and temporal regulation of its activity through modulatory mechanisms involving its expression, localization, enzymatic activity, and protein–protein interactions. The residence of the NKA at the plasma membrane is compulsory for its action as an antiporter. Despite the huge body of literature reporting on its trafficking between the cell membrane and intracellular compartments, the mechanisms controlling the trafficking process are by far the least understood. Among the molecular determinants of the plasma membrane proteins trafficking are intrinsic sequence-based endocytic motifs. In this review, we (i) summarize previous reports linking the regulation of Na+/K+ ATPase trafficking and/or plasma membrane residence to its activity, with particular emphasis on the endocytic signals in the Na+/K+ ATPase alpha-subunit, (ii) map additional potential internalization signals within Na+/K+ ATPase catalytic alpha-subunit, based on canonical and noncanonical endocytic motifs reported in the literature, (iii) pinpoint known and potential phosphorylation sites associated with NKA trafficking, (iv) highlight our recent studies on Na+/K+ ATPase trafficking and PGE2-mediated Na+/K+ ATPase modulation in intestine, liver, and kidney cells.
Combination of DBD and Catalysts for CH4 and CO2 Conversion: Basics and Applications
Authors: Nozaki Tomohiro , Chen Xiaozhong , Kim Dae-Yeong , Zhan Chunyuan 
Published: August 2023

AbstractThis paper describes dielectric barrier discharge and catalyst combination technology which is applied for dry methane reforming (DMR: CH4 + CO2 = 2CO + 2H2) and reverse water gas shift reaction (RWGS: CO2 + H2 = CO + H2O). The purpose of this paper is not to discuss the efficiency of plasma catalytic conversion of CH4 and CO2, catalyst synthesis method, or diagnostics of surface reactions; it focuses on the macroscopic characterization of DBD and catalyst hybrid reactions for a reactor design and appropriate parameter setting. DBD is characterized by the discharge sustain voltage and the mean discharge current which are readily obtainable from the Lissajous diagram and is further correlated with a power density (W/m3) via Manley's equation. Meantime, power density is decoupled into specific energy density (SEI) and gaseous space velocity (GHSV). SEI provides a guideline for the energy efficiency of the plasma catalytic process, and GHSV is an important measure of residence time or productivity of the process. The DBD-catalyst hybrid reaction is superior to warm discharge alone when it is generated by a high-frequency power source, which is discussed based on the lifetime of vibrationally excited CH4; not only cumulative population of a fundamental mode of vibrationally excited CH4, but also overtone vibrational states of CH4 is anticipated by multiple electron collision at high-frequency operation. The importance of overtone vibrational molecules on surface reaction is proven by molecular beam study, and distinguished from the ladder-climbing mechanism in gas phase plasma chemistry; catalytic reactions would further promote without unavoidable trade-off relationship between reactant conversion rate and energy efficiency. Finally, nonequilibrium product distribution by plasma catalysis is discussed based on the surface reaction model in connection with vibrationally excited molecules.
SubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters
Authors: Pepin Xavier J. H. , Grant Iain , Wood J. Matthew 
Published: August 2023

AbstractPurposeTo construct a detailed mechanistic and physiologically based biopharmaceutics model capable of predicting 1) device-formulation-tissue interaction during the injection process and 2) binding, degradation, local distribution, diffusion, and drug absorption, following subcutaneous injection. This paper is part of a series and focusses on the first aspect.MethodsA mathematical model, SubQ-Sim, was developed incorporating the details of the various substructures within the subcutaneous environment together with the calculation of dynamic drug disposition towards the lymph ducts and venous capillaries. Literature was searched to derive key model parameters in healthy and diseased subjects. External factors such as body temperature, exercise, body position, food or stress provide a means to calculate the impact of “life events” on the pharmacokinetics of subcutaneously administered drugs.ResultsThe model predicts the tissue backpressure time profile during the injection as a function of injection rate, volume injected, solution viscosity, and interstitial fluid viscosity. The shape of the depot and the concentrations of the formulation and proteins in the depot are described. The model enables prediction of formulation backflow following premature needle removal and the resulting formulation losses. Finally, the effect of disease (type 2 diabetes) or the presence of recombinant human hyaluronidase in the formulation on the injection pressure, are explored.ConclusionsThis novel model can successfully predict tissue back pressure, depot dimensions, drug and protein concentration and formulation losses due to incorrect injection, which are all important starting conditions for predicting drug absorption from a subcutaneous dose. The next article will describe the absorption model and validation against clinical data.
Near-death experiences: feasibility and advantages of the mechanistic explanation
Authors: Oleksowicz Michał , Gaitán Leandro 
Published: August 2023

AbstractThe new mechanistic philosophy seeks to identify and explain the mechanisms of various phenomena, including their overall organization and the interactions between the individualized components. This paper argues that among the phenomena that can be approached within the new mechanistic framework are near-death experiences, which can be included within the vast range of experiences that are grouped under the category of religious experience. Such experiences involve a complex set of cognitive, affective, and behavioural processes. Since studying such experiences is far from methodologically simple, we try to show the feasibility of applying the mechanistic explanation to near-death experiences. While some scholars (such as Egil Asprem and Ann Taves) argue that mechanistic explanation can shed new light on the explanation of religion, we instead emphasize neglected limits of such an explanation, as well as its epistemic-methodological advantages in comparison with alternative explanatory models, especially the models proposed by Michael Marsh, Frederick S. Barrett and Roland R. Griffiths.
Dynamic chest radiography for pulmonary vascular diseases: clinical applications and correlation with other imaging modalities
Authors: Yamasaki Yuzo , Kamitani Takeshi , Sagiyama Koji , Hino Takuya , Kisanuki Megumi , Tabata Kosuke , Isoda Takuro , Kitamura Yoshiyuki , Abe Kohtaro , Hosokawa Kazuya , Toyomura Daisuke , Moriyama Shohei , Kawakubo Masateru , Yabuuchi Hidetake , Ishigami Kousei 
Published: August 2023

AbstractDynamic chest radiography (DCR) is a novel functional radiographic imaging technique that can be used to visualize pulmonary perfusion without using contrast media. Although it has many advantages and clinical utility, most radiologists are unfamiliar with this technique because of its novelty. This review aims to (1) explain the basic principles of lung perfusion assessment using DCR, (2) discuss the advantages of DCR over other imaging modalities, and (3) review multiple specific clinical applications of DCR for pulmonary vascular diseases and compare them with other imaging modalities.
Evaluation of the ear ossicles with photon-counting detector CT
Authors: Takahashi Yuka , Higaki Fumiyo , Sugaya Akiko , Asano Yudai , Kojima Katsuhide , Morimitsu Yusuke , Akagi Noriaki , Itoh Toshihide , Matsui Yusuke , Hiraki Takao 
Published: August 2023

AbstractRecently, computed tomography with photon-counting detector (PCD-CT) has been developed to enable high-resolution imaging at a lower radiation dose. PCD-CT employs a photon-counting detector that can measure the number of incident X-ray photons and their energy. The newly released PCD-CT (NAEOTOM Alpha, Siemens Healthineers, Forchheim, Germany) has been in clinical use at our institution since December 2022. The PCD-CT offers several advantages over current state-of-the-art energy-integrating detector CT (EID-CT). The PCD-CT does not require septa to create a detector channel, while EID-CT does. Therefore, downsizing the anode to achieve higher resolution does not affect the dose efficiency of the PCD-CT. CT is an indispensable modality for evaluating ear ossicles. The ear ossicles and joints are clearly depicted by PCD-CT. In particular, the anterior and posterior legs of the stapes, which are sometimes unclear on conventional CT scans, can be clearly visualized. We present cases of congenital anomalies of the ossicular chain, ossicular chain dislocation, tympanosclerosis, and cholesteatoma in which PCD-CT was useful. This short article reports the usefulness of PCD-CT in the 3D visualization of the ear ossicles.
Linking Ambivalent Sexism to Violence-Against-Women Attitudes and Behaviors: A Three-Level Meta-analytic Review
Authors: Gutierrez Brenda C. , Leaper Campbell 
Published: August 2023

AbstractAmbivalent sexism (hostile and benevolent sexism) maintains gender inequalities and has been applied to investigate violence against women (VAW). We conducted a comprehensive three-level meta-analytic review testing ambivalent sexism as predictors of VAW-supportive attitudes and behaviors regarding sexual harassment, sexual assault, and intimate partner violence. Relevant articles published between 1996 and April 2022 were retrieved from the PsycINFO, Pro Quest Dissertations and Theses, Cochrane Database Reviews, ERIC, and Web of Science online databases. A total of 141 reports (with 912 unique effect sizes) met our inclusion criteria (e.g., assessed Glick and Fiske’s 1996 ASI and at least one self-reported measure of VAW-supportive attitudes or men's VAW perpetration and/or proclivity; VAW was limited to violence against women perpetrated by men). Our review revealed hostile and benevolent sexism, respectively, were associated with greater VAW-supportive attitudes across genders (r = .47, 95% CI [.43–.50]; r = .26, 95% CI [.23–.29]) and to greater VAW behaviors among men (r = .23, 95% CI [.19–.27]; r = .08, 95% CI [.04–.12]). Our review also highlighted participant gender, VAW type, and domain of VAW as important moderators. Notably, benevolent sexism was more strongly tied to VAW-supportive attitudes among women (r = .31, 95% CI [.27–.35]) than men (r = .22, 95% CI [.18–.26]). Overall, the results underscore the importance of addressing hostile and benevolent sexism in future research and interventions on VAW.
Culture-based Determination of Verticillium Densities in Soil Overestimates Disease Pressure of Verticillium Wilt of Potato in Manitoba
Authors: Molina Oscar I. , Henriquez Maria A. , Tenuta Mario 
Published: August 2023

AbstractVerticillium wilt affects potato fields in Manitoba where 80% of the fields are planted to the moderately susceptible cultivar, Russet Burbank. An accurate determination of Verticillium dahliae inoculum in soil is critical for disease management. In this study, we investigated the presence of microsclerotia-producing Verticillium species in potato fields in Manitoba and compared published quantitative real-time PCR assays for V. dahliae, V. tricorpus and V. longisporum against a traditional plating method. Selected real-time PCR assays could differentiate and quantify the major microsclerotia-producing species, V. dahliae, V. tricorpus and V. longisporum. Results showed that the presence of V. tricorpus caused an overestimation of V. dahliae propagule density when using the plating method. As a result, Verticillium wilt severity was negatively related to cfu from traditional plating, while positive with the amounts of V. dahliae genomic DNA in soils.
Evaluating the design of digital tools for the transition to an e-continuous assessment in higher education
Authors: Castillo-Manzano José I. , Castro-Nuño Mercedes , López-Valpuesta Lourdes , Sanz-Díaz María Teresa , Yñiguez Rocío 
Published: August 2023

AbstractEvaluation is a crucial part of the teaching and learning process in any higher education institution and one that has gone through a deep change. This has been particularly true since the Bologna Declaration (http://www.ehea.info/page-ministerial-conference-bologna-1999, 1999) ushered in the European higher education area, with the subsequent major rise in the employment of continuous assessment methods focused on student participation. This article analyses the impact on academic performance of e-continuous assessment based on e-tests on a virtual platform as a previous step towards the substitution of the traditional evaluation system, based on a final exam, with a continuous evaluation system, prescribed as an alternative preferred by the regulations of multiple Spanish universities. Microeconometric models have been applied to a database of 250 first-year students on the Business Administration and Management course at the University of Seville (Spain). Our findings show that e-tests could prevent the risk of students dropping out and could also provide a credible predictor of students’ academic marks in the theoretical contents of the subject, but not in those of a practical or applied nature. Based on the results of this evaluation, an e-continuous assessment has been developed in the subject, which has become the majority option for students, with 90% participation, while also increasing pass rates. Moreover, the positive effect of a computing environment does not appear to be limited to the classroom, but also extends to students’ home environments. This teaching experience shows that the swift feedback that e-tools provides, especially in especially in environments of large class size such as in the class evaluated, could support instructors’ personal tutoring of students’ progress and promote a greater implementation of e-continuous assessment in Spanish higher education.
Tergomyan molluscs from the Early Ordovician of the Llangynog Inlier, South Wales, UK
Authors: Cope John C. W. , Ebbestad Jan Ove R. 
Published: August 2023

AbstractA low abundance but diverse fauna of tergomyan molluscs is described from the Llangynog Inlier, Carmarthenshire, South Wales. The specimens originate from a single quarry exposing shallow-water siltstone and mudstone beds of the Early Arenig (early Floian) Bolahaul Member of the Ogof Hên Formation. The fauna includes Proplina areniga sp. nov., Proplina? obtusa sp. nov., Celtopileus calvapex gen. et sp. nov. with preserved muscle scars, Costulaconus mirificus gen. et sp. nov., and Hypseloconus? sp. Comparable tryblidiid taxa are mainly found in the Lower Ordovician of Midwestern USA among species of Proplina Kobayashi, 1933 and Gasconadeoconus Stinchcomb, 1986. The tentative assignment of the predominantly late Cambrian Hypseloconus is symptomatic of the many uncertainties regarding the phylogeny of the tryblidiids. The diverse assemblage of organisms preserved at the single locality represents one of the most remarkable faunas of this age worldwide.
Interference KRT17 reverses doxorubicin resistance in triple-negative breast cancer cells by Wnt/β-catenin signaling pathway
Authors: Wu Liqiong , Ding Wenshuang , Wang Xiaopai , Li Xiubo , Yang Jing 
Published: August 2023

Abstract
Background
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with the highest degree of malignancy and is easily resistant to drugs due to the lack of hormone receptors. Research on the resistance mechanisms in TNBC is particularly important. Keratin 17 (KRT17) is highly expressed in TNBC. Anthracycline doxorubicin (Dox) is a commonly used chemotherapeutic drug for early stage triple-negative breast cancer.

Objective
This study investigated the role of KRT17 in TNBC-Dox resistance.

Methods
Immuno-histochemical staining, qPCR, western blotting (WB), and immunofluorescence were used to detect the expression of KRT17 in TNBC-Dox-resistant patients and in TNBC-Dox-resistant MDA-MB-468 and MDA-MB-231. the effect of KRT17 on the proliferation and migration in KRT17 knockdown of TNBC-Dox-resistant cells was determined by the CCK8, clone formation, transwell invasion and wound healing assays were used to determine.

Results
KRT17 was highly expressed in the TNBC-Dox-resistant cells. Knockdown of KRT17 significantly reduced the IC50s of TNBC-Dox-resistant and parental strains and also reduced the proliferation and invasion abilities of TNBC-Dox-resistant cell lines. KRT17 regulated the Wnt/β-catenin signaling pathway. The inhibitory effect of KRT17 knockdown on the proliferation and migration of TNBC-Dox-resistant cells was reversed by an activator of the Wnt signaling pathway.

Conclusion
KRT17 can inhibit the Wnt/β-catenin signaling pathway, thereby reducing the proliferation and invasion ability of TNBC-Dox-resistant cells.
Benefits of co-creating higher education learning resources: an industry participant perspective
Authors: Laundon Melinda , Williams Penny , Williams Jannine 
Published: August 2023

AbstractThis study investigates the perceived benefits to industry experts who engage with academics to co-create higher education learning resources. Academics are increasingly impelled to involve industry experts in learning and teaching to ensure that curriculum is authentic and relevant and prepares students for future professional careers. While benefits to students are well established by prior research, individual-level research into industry experts’ motivations to contribute to higher education is scant. When approached to co-create authentic learning resources for postgraduate students, industry experts expressed motivations which focused on three areas: desire to maintain valued relationships with academics or the university, desire to improve the student experience by developing innovative learning resources to bridge the gap between theory and practice and desire to build and promote their profession. In-depth, semi-structured interviews with nine human resource management industry experts identified that the benefits of co-creating learning resources went beyond their stated motivations to include unanticipated benefits which can be explained by the professionalism literature. We outline a taxonomy of benefits for industry experts engaging in co-creating authentic learning resources: students, the professional self, the professional community and the organisation. The implications are that universities and academics may draw on these broader benefits to encourage industry experts to participate in higher education learning resource development. The study provides insights into the potential for industry experts to engage in professional self-reflection by contributing to higher education teaching and learning.
Revisiting Universal Variables for Robust, Analytical Orbit Propagation Under the Vinti Potential
Authors: Biria Ashley D. 
Published: August 2023

AbstractTo meet the growing complexity and demands of modern spacecraft missions, analytical solutions to initial value problems see continued use, typically supporting global searches of large trajectory design spaces. These efforts often employ universal two-body orbit propagators for their recognized speed and robustness, but many applications, like active space debris removal, would benefit from a comparable propagator with greater accuracy. Vinti propagators, which consider planetary oblateness, may serve this purpose, but existing Vinti solutions possess computational difficulties in certain orbital regimes. To mitigate these deficiencies, the present study develops and validates an analytical, third-order universal Vinti propagator free of computational difficulties by leveraging standard, oblate spheroidal (OS) universal variables and OS equinoctial orbital elements. Accuracy of the third-order approximation is assessed for multiple examples across an array of orbital regimes. Computational runtime is also evaluated, and performance is directly compared to the benchmark algorithm. On average, the Vinti propagator implemented in this work is only slower than a typical universal Kepler propagator by a factor of 4.0 and slower than by a factor of 1.8, but with greater robustness than the benchmark. The new form of the equations of motion also has favorable implications for the associated boundary value problem.
Clinicians’ perspectives on PET/CT in oncological patients: an Italian National Survey
Authors: Santo Giulia , Miceli Alberto , Lazzarato Achille , Gorica Joana , Nappi Anna Giulia , Jonghi-Lavarini Lorenzo , Dondi Francesco , La Torre Flavia , Filice Angelina , De Rimini Maria Luisa , Evangelista Laura , Panareo Stefano ,   On the behalf of the Young Italian Association of Nuclear Medicine (AIMN) Working Group
Published: August 2023

Abstract
Introduction
The present web-based national survey aims to assess the clinician's perspective toward (1) the indications to perform positron emission tomography/computed tomography (PET/CT) in cancer patients, (2) the utility of the interaction with the referring nuclear medicine physician, and (3) their perception of the clarity, usefulness, and the impact of the PET/CT report.

Methods
We conducted a prospective web-based survey consisting of 31 multiple-choice questions and an open-text field. The questionnaire was administered to Italian clinicians or surgeons who managed oncological patients. Data were analyzed using standard diagrams and the values were expressed as numbers (percentages).

Results
A total of 373 physicians completed the questionnaire. Among the 360 responses finally included in the analysis, the majority came from radiation oncologists (46%), followed by oncologists. For half of the respondents (53%), indications to perform PET/CT examination were “often” clear and easily accessible, but only 16% considered them “absolutely” clear and accessible. Additionally, most respondents (43%) considered “absolutely” necessary to facilitate access to PET/CT indications and their update. The interaction with the referring nuclear medicine physician was generally useful and satisfying. Regarding the nuclear medicine report, 74% considered “absolutely” useful to standardize the report structure, and the presence of semi-quantitative parameters was considered of great importance. Finally, in about half of the cases (53%), PET/CT report impacts patient management with major changes.

Conclusion
To sum up, a “still not” complete confidence with PET/CT indications and the need to facilitate access to indications and their update emerged from our results. Moreover, a structured PET/CT report with a clarification on essential PET features is warranted. In this scenario, the participation of nuclear medicine physicians in guideline oncological committees, national and international oncological conferences as well as continuous training among all specialists involved in cancer patients’ management could be effective strategies to resolve clinicians' concerns about PET/CT, thereby improving the management of cancer patients.