bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quadrature Domains for the Helmholtz Equation with Applications to Non-scattering Phenomena
Authors: Kow Pu-Zhao , Larson Simon , Salo Mikko , Shahgholian Henrik 
Published: December 2022

AbstractIn this paper, we introduce quadrature domains for the Helmholtz equation. We show existence results for such domains and implement the so-called partial balayage procedure. We also give an application to inverse scattering problems, and show that there are non-scattering domains for the Helmholtz equation at any positive frequency that have inward cusps.
Influence of Surface Roughness on Press Fits
Authors: Persson B. N. J. 
Published: December 2022

AbstractA press fit, also known as interference fit or friction fit, is a form of fastening between two tight fitting mating parts (usually two bodies with cylinder or conical surfaces) that produces a joint which is held together by friction after the parts are pushed together. I discuss the influence of surface roughness on the design of press fits. This topic has been addressed in the engineering community but only on an empirical level without a scientific backup. Here, I will apply the Persson contact mechanics theory to show how to include the surface roughness in the design criteria. I argue that one should use what I denote as the cylinder “stylus width” rather than the “caliper width” when determining the influence of the surface roughness of the compression (also denoted as the interference). In the classical approach using the caliper width, the compression is assumed to be independent of the elastic properties of the solids, but in the more accurate approach presented here using the stylus width the compression depends on the elastic properties and on the surface roughness power spectra of the involved solids. A detailed discussion of the relation between the root-mean-square roughness amplitude $$h_{\mathrm{rms}}$$

h
rms

and the maximum asperity height $$h_{\mathrm{max}}$$

h
max

, of interest in its own right, is also presented as it is needed for determining the relation between the stylus and caliper derived compression’s.
Graphical Abstract
Topsoil Carbon Stocks in Urban Greenspaces of The Hague, the Netherlands
Authors: Kortleve Anniek J. , Mogollón José M. , Heimovaara Timo J. , Gebert Julia 
Published: December 2022

AbstractUrbanization influences soil carbon (C) stocks and flows, which, in turn, affect soil-derived ecosystem services. This paper explores soil C storage in urban greenspaces in the Dutch city of The Hague along a transect from the suburban seaside towards the city centre, reflecting a toposequence from dune to peaty inland soils. C storage and C mineralisation potential were evaluated in relation to soil type and greenspace categories. Several soil-quality characteristics were measured, including dissolved organic C, pH, electrical conductivity, nitrogen, phosphorus, sulphur, calcium carbonate, and the water-holding capacity of the soil to evaluate what drives soil C storage in the urban context. The total SOC storage of the upper 30 cm of the greenspaces in The Hague (20.8 km2 with 37% greenspace) was estimated at 78.4 kt, which was significantly higher than assumed given their soil types. Degradability of soil organic matter in laboratory batch tests varied between 0.2 and 3 mg C gSOC−1 day−1. Degradability was highest in the seaside dune soils; however, extrapolated to the topsoil using the bulk density, topsoil C mineralization was higher in the urban forest. Soils beneath shrubs appeared to be hotspots for C storage, accounting for only 13% of the aerial cover but reflecting 24% of the total C storage. Land ownership, land use, greenspaces size, litter management and soil type did not result in significantly different C stocks, suggesting that processes driving urban soil C storage are controlled by different factors, namely land cover and the urbanization extent.
Influencing factors on ureolytic microbiologically induced calcium carbonate precipitation for biocementation
Authors: Erdmann N. , Strieth D. 
Published: December 2022

AbstractMicrobiologically induced calcium carbonate precipitation (MICP) is a technique that has received a lot of attention in the field of geotechnology in the last decade. It has the potential to provide a sustainable and ecological alternative to conventional consolidation of minerals, for example by the use of cement. From a variety of microbiological metabolic pathways that can induce calcium carbonate (CaCO3) precipitation, ureolysis has been established as the most commonly used method. To better understand the mechanisms of MICP and to develop new processes and optimize existing ones based on this understanding, ureolytic MICP is the subject of intensive research. The interplay of biological and civil engineering aspects shows how interdisciplinary research needs to be to advance the potential of this technology. This paper describes and critically discusses, based on current literature, the key influencing factors involved in the cementation of sand by ureolytic MICP. Due to the complexity of MICP, these factors often influence each other, making it essential for researchers from all disciplines to be aware of these factors and its interactions. Furthermore, this paper discusses the opportunities and challenges for future research in this area to provide impetus for studies that can further advance the understanding of MICP.
Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer’s disease
Authors: Ballesteros-Álvarez Josué , Nguyen Wynnie , Sivapatham Renuka , Rane Anand , Andersen Julie K. 
Published: December 2022

Abstract
In the present study, we investigated the effects of urolithin A (UA), a metabolite generated from ellagic acid via its metabolism by gut bacteria, as an autophagy activator with potential neuroprotective activity. WT and 3xTg-AD mice were administered long-term intermittent dietary supplementation with UA. UA was found to prevent deficits in spatial memory, cued fear response, and exploratory behavior in this model. It also decreased the Aβ plaque burden in areas of the hippocampus where these protein deposits are prominent in the model. Interestingly, correlation analyses demonstrate that Aβ plaque burden positively correlates with enhanced spatial memory in 3xTg-AD mice on a control diet but not in those supplemented with UA. In contrast, Aβ42 abundance in cortical and hippocampal homogenates negatively correlate with spatial memory in UA-fed mice. Our data suggest that plaque formation may be a protective mechanism against neurodegeneration and cognitive decline and that targeting the generation of proteotoxic Aβ species might be a more successful approach in halting disease progression. UA was also found to extend lifespan in normal aging mice. Mechanistically, we demonstrate that UA is able to induce autophagy and to increase Aβ clearance in neuronal cell lines. In summary, our studies reveal UA, likely via its actions as a autophagy inducer, is capable of removing Aβ from neurons and its dietary administration prevents the onset of cognitive deficits associated with pathological Aβ deposition in the 3xTg-AD mouse model as well as extending lifespan in normal aging mice.
Biodegradable Mg Electrodes for Iontophoretic Transdermal Drug Delivery
Authors: Jeong Goeen , Han Hyung-Seop , Jeon Hojeong , Kim Yu-Chan , Jang Ho Won , Ok Myoung-Ryul 
Published: December 2022

AbstractBiodegradable metals have received limited attention for application in transdermal drug delivery, although metallic microneedles (MNs) and iontophoresis have been thoroughly researched for this purpose. Here, we present Mg as a salient candidate for an MN electrode. Its metallic properties enable the application of voltage to enhance the diffusion of charged drug molecules, while hydrogen gas generated during Mg corrosion prevents its application to electrodes. The Mg MN electrode was fabricated using a nanosecond laser, and the amount of hydrogen gas were measured with applied potential during iontophoresis. Accordingly, an appropriate potential window for iontophoresis was established based on the combined effect of enhanced drug diffusion by applied electric potential and impediment from hydrogen generation. The dye permeation tests of the Mg MN on the porcine skin demonstrated the combined effect of the Mg MN and iontophoresis. The dye migration decreased at higher voltages due to excess hydrogen generation and the corrosion of needle tips, both making the diffusion of charged dye molecules along the Mg MN surface harder. These results demonstrate optimal potential range of Mg MN electrodes for transdermal drug delivery with an electric field and bubble generation during iontophoresis.Graphical Abstract
Bohemicardia hainense (Maurer) revisted: insights into ontogeny and variability of a Devonian hippocardiid rostroconch (Conocardiida: Hippocardiidae)
Authors: Friedel Julia C. , Amler Michael R. W. , Balik Berna 
Published: December 2022

AbstractRe-examination of type material and abundant specimens enable the reinstatement of ‘Conocardium hainense Maurer, 1885’, a species erroneously synonymised with Babinicardia clathrata by Rogalla and Amler. Based on the completely reconstructed morphology, C. hainense can be assigned to the genus Bohemicardia within the Hippocardiidae of the Hippocardioidea. About 600 specimens from a single locality available for study including a wide range of ontogenetic stages allow documentation of allometric growth, with shell width increasing faster than shell height. Protoconchs are not preserved, leaving the development from larval stages to early juveniles unrecorded. The large number of specimens confirms a rather narrow range of morphological variation within the taxon. Based on the preservation of the rarely observed external shell layer, conclusions on shell shape, presence of a hood and external shell ornamentation of the taxon are possible. The material confirms that recognising different shell layer architecture in conocardiid rostroconchs is a prerequisite for specific identification and basic taxonomy.
The Potential of Prairie Pothole Wetlands as an Agricultural Conservation Practice: A Synthesis of Empirical Data
Authors: Ross Caryn D. , McKenna Owen P. 
Published: December 2022

AbstractNutrient pollution causing harmful algal blooms and eutrophication is a major threat to aquatic systems. Throughout North America, agricultural activities are the largest source of excess nutrients entering these systems. Agricultural intensification has also been a driver in the historical removal of depressional wetlands, contributing to increased hydrological connectivity across watersheds, and moving more nutrient runoff into terminal waterbodies such as the Laurentian Great Lakes and Gulf of Mexico. The Prairie Pothole Region of North America (PPR) supports grassland, cropland, wetland, and riverine systems that connect to the Missouri, Mississippi, and Red River Basins. There is a need to synthesize scientific understanding to guide more targeted conservation efforts and better understand knowledge gaps. We reviewed 200 empirical studies and synthesized results from across a minimum of 9 and maximum of 43 wetland basins (depending on the variable data available). We found an average wetland removal rate of nitrate and phosphate of 53% and 68%, respectively. Literature also showed sedimentation rates to be twice as high in wetland basins situated within croplands compared to grasslands. Our synthesis enhances understanding of nutrient processing in wetlands of the PPR and highlights the need for more empirical field-based studies throughout the region.
Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality
Authors: Skibińska Izabela , Andrusiewicz Mirosław , Jendraszak Magdalena , Żbikowska Aleksandra , Jędrzejczak Piotr , Kotwicka Małgorzata 
Published: December 2022

AbstractSperm cells are target cells for both estrogens and xenoestrogens. Due to the specific structure of spermatozoa, these hormonal compounds may act on sperm in a non-genomic mechanism only. However, the ESR-mediated signaling pathways are still poorly understood. In this study, we obtained 119 samples from male participants of Caucasian descent who donated semen for standard analysis. We analyzed gene expression of estrogen receptors (ESR1andESR2) and their coregulators—proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), and cellular kinase c-Src (SRC). RNA level was established using reverse-transcribed RNA as a template, followed by a polymerase chain reaction. Proteins’ presence was confirmed by western blot and immunocytochemistry techniques. “Normal” values of semen parameters were defined as follows: > 32% sperm with progressive motility, > 4% sperm cells with normal morphology, > 15 × 106sperm per mL, > 58% live spermatozoa and leukocyte amount < 106cells per mL, according to WHO 2010 reference. Semen parameters that deviated from these “normal” values were labeled as “abnormal”. Gene expression ratios revealed significant, moderate, and negative correlations forESR1/ESR2and weak, negativeESR2/PELP1correlations in the subgroup of patients with abnormal values of semen parameters. In addition, SRC/PELP1 was moderately and positively correlated in the subgroup with parameters within the reference values established by WHO 2010. Our study showed that both PELP1 scaffolding protein and SRC kinase might influence semen quality via ESRs. It seems that not the expression of a single gene may affect the sperm quality, but more gene-to-gene mutual ratio. Characterization of estrogen-signaling pathway-related genes’ modulated expression in sperm cells could aid in better understanding sperm biology and quality.
Development of a new correlation for pre-dry out evaporative heat transfer coefficient of R290 in a microchannel
Authors: Ghazali Muhammad Aliff Haikal , Mohd-Yunos Yushazaziah , Pamitran Agus Sunjarianto , Jong-Taek Oh , Mohd-Ghazali Normah 
Published: December 2022

AbstractAlthough many correlations have and are being developed for two-phase heat transfer coefficient correlation in microchannels, none has the desired accuracy yet. This paper presents prospective improvements in the convective heat transfer coefficient correlation accuracy for the dry-out conditions; when the heat transfer coefficient drops at a certain vapor quality. An accurate heat transfer coefficient forecast is needed to minimize over or under design, conserve energy and material, and maximize the performance. R290 has been reported to be more energy efficient than R22. A new correlation relevant for R290 across 831 sets of experimental data points in a microchannel was generated by optimizing six variables in the nucleate boiling suppression factor, S, and force convective factor, F, of a selected superposition type correlation. The new correlation was optimized for saturation temperature ranging between 5 and 25 °C, diameter ranging between 1.0 and 6.0 mm, heat flux ranging between 2.5 and 60 kW/m2, and mass flux ranging between 50 and 500 kg/m2s. The MAE was reduced from 21.84 to 17.02% for pre-dry out data. The new correlation may be utilized to estimate the heat transfer coefficient of R290 in heat transfer analysis in a microchannel under the investigated operating conditions. The optimization approach utilized here has the potential of continuously improving the MAE of any heat transfer correlation for any refrigerants considered.
Multi‐Year CALIPSO Observations of Ubiquitous Elevated Aerosol Layer in the Free Troposphere Over South Asia: Sources and Formation Mechanism
Authors: Kumar G. , Madhavan B. L. , Sahu L. K. , Kumar Y. B. , Vernier J.‐P. , Liu H. , Zhang B. , Pandit A. K. , Manchanda R. K. , Dadhwal V. K. , Sinha P. R. 
Published: December 2022

AbstractThe vertical distribution of aerosols in the lower troposphere is critically important for assessing their impact on Earth's radiation budget and modulation of cloud microphysics. This study analyzed cloud‐free aerosol extinction coefficient (βext), aerosol subtypes, and particulate depolarization ratios obtained from CALIOP (Cloud‐Aerosol Lidar with Orthogonal Polarization) over the six regions of India during 2008–2018. We investigated unprecedented climatology of the physical and optical characteristics of elevated aerosol layers (EALs) along with their source and formation mechanism. The key findings include: (a) EALs over the Indian region were persistent between 4 and 6 km during all seasons, (b) geometrical layer thickness of EALs increased up to 36.7% and 25% from the annual mean during summer and fall seasons, respectively, compared to that of spring and winter, (c) dust and polluted dust accounted for up to 50%–80% from near‐surface to 6 km and up to 80%–90% of the EALs between 4 and 6 km, respectively for all the seasons and regions, (d) we anticipated that locally confined recirculation coupled with stratified stable layer capped within turbulent layers could be a possible mechanism of formation of stratified EALs between 4 and 6 km during winter‐spring‐fall, while in summer, vertical transport of pollutants from the PBL to mid‐troposphere due to enhanced deep convection served as a key formation mechanism of the EALs, (e) the second Modern‐Era Retrospective analysis for Research and Applications Global Modeling Initiative model reasonably simulated the shape and vertical gradient of βext with significant differences in magnitude below 4 km; however, it fails to reproduce EALs for all seasons and regions during the study period.
Water Availability and Land Management Control Catchment‐Scale Agricultural Nitrogen and Phosphorous Use Efficiencies
Authors: Scaini Anna , Vico Giulia , Thorslund Josefin , Hugelius Gustaf , Manzoni Stefano 
Published: December 2022

AbstractIn arable systems, large amounts of nutrients, particularly of nitrogen (N) and phosphorus (P), are not efficiently converted into harvestable products and are lost from agricultural systems, with negative consequences for agricultural productivity and the environment. These nutrient losses are mediated by hydroclimatic processes causing nutrient leaching and volatilization. We quantify over the period 1987–2012 how water availability through the evaporative ratio (actual evapotranspiration divided by precipitation) and irrigation, agricultural practices, and edaphic conditions jointly affect nutrient use efficiencies in 110 agricultural catchments in the United States. We consider N and P use efficiencies (nitrogen use efficiency [NUE] and phosphorous use efficiency [PUE]) defined as ratios of catchment‐scale N and P in harvested products over their respective inputs, as well as the NUE/PUE ratio, as an indication of catchment‐scale N and P imbalance. Both efficiencies increase through time because of changes in climate and agronomic practices. Setting all else at the median value of the data set, NUE and PUE increased with evaporative ratio by 0.5% and 0.2% when increasing the evaporative ratio by 20% and by 4.9% and 18.8% in the presence of irrigation. NUE was also higher in catchments where maize and soybean were dominant (increasing by 2.3% for a 20% increase in maize and soybean fractional area). Soil properties, represented by mineral soil texture and organic matter content, had only small effects on the efficiencies. Our results show that both climatic conditions and crop choice are important drivers of nutrient use efficiencies in agricultural catchments.
Seeking Repeating Anthropogenic Seismic Sources: Implications for Seismic Velocity Monitoring at Fault Zones
Authors: Sheng Y. , Mordret A. , Brenguier F. , Boué P. , Vernon F. , Takeda T. , Aoki Y. , Taira T. , Ben‐Zion Y. 
Published: December 2022

AbstractSeismic velocities in rocks are highly sensitive to changes in permanent deformation and fluid content. The temporal variation of seismic velocity during the preparation phase of earthquakes has been well documented in laboratories but rarely observed in nature. It has been recently found that some anthropogenic, high‐frequency (>1 Hz) seismic sources are powerful enough to generate body waves that travel down to a few kilometers and can be used to monitor fault zones at seismogenic depth. Anthropogenic seismic sources typically have fixed spatial distribution and provide new perspectives for velocity monitoring. In this work, we propose a systematic workflow to seek such powerful seismic sources in a rapid and straightforward manner. We tackle the problem from a statistical point of view, considering that persistent, powerful seismic sources yield highly coherent correlation functions (CFs) between pairs of seismic sensors. The algorithm is tested in California and Japan. Multiple sites close to fault zones show high‐frequency CFs stable for an extended period of time. These findings have great potential for monitoring fault zones, including the San Jacinto Fault and the Ridgecrest area in Southern California, Napa in Northern California, and faults in central Japan. However, extra steps, such as beamforming or polarization analysis, are required to determine the dominant seismic sources and study the source characteristics, which are crucial to interpreting the velocity monitoring results. Train tremors identified by the present approach have been successfully used for seismic velocity monitoring of the San Jacinto Fault in previous studies.
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
Authors: Sæther Linn Sofie , Ueland Thor , Haatveit Beathe , Maglanoc Luigi Angelo , Szabo Attila , Djurovic Srdjan , Aukrust Pål , Roelfs Daniel , Mohn Christine , Ormerod Monica Bettina Elkjaer Greenwood , Lagerberg Trine Vik , Steen Nils Eiel , Melle Ingrid , Andreassen Ole Andreas , Ueland Torill 
Published: December 2022

AbstractA potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for inter-individual variance in both cognitive functioning and inflammatory/immune status. This study aimed to investigate covariance patterns between inflammatory/immune-related markers and cognitive domains and further elucidate heterogeneity in a large SMI and healthy control (HC) cohort (SZ = 343, BD = 289, HC = 770). We applied canonical correlation analysis (CCA) to identify modes of maximum covariation between a comprehensive selection of cognitive domains and inflammatory/immune markers. We found that poor verbal learning and psychomotor processing speed was associated with higher levels of interleukin-18 system cytokines and beta defensin 2, reflecting enhanced activation of innate immunity, a pattern augmented in SMI compared to HC. Applying hierarchical clustering on covariance patterns identified by the CCA revealed a high cognition—low immune dysregulation subgroup with predominantly HC (24% SZ, 45% BD, 74% HC) and a low cognition—high immune dysregulation subgroup predominantly consisting of SMI patients (76% SZ, 55% BD, 26% HC). These subgroups differed in IQ, years of education, age, CRP, BMI (all groups), level of functioning, symptoms and defined daily dose (DDD) of antipsychotics (SMI cohort). Our findings suggest a link between cognitive impairment and innate immune dysregulation in a subset of individuals with severe mental illness.