bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of MI-oriented versus CBT-oriented adjunctive treatments: impacts on therapeutic alliance and patient engagement during hospital treatment for an eating disorder
Authors: Mills Jennifer S. , Poulin Lauren E. , Kirsh Gillian 
Published: June 2023

Abstract
Background
Our aim was to compare MI-oriented versus CBT-oriented adjunctive treatments to test whether an MI approach is superior in terms of improving therapeutic alliance and engagement among individuals with an eating disorder. The current study was a pilot randomized controlled trial with random allocation to either MI-oriented or a CBT-oriented adjunctive treatment group completed concurrently with a hospital-based group program for adults. Both adjunctive treatment conditions consisted of three individual therapy sessions and a self-help manual.

Methods
Sixty-five outpatients receiving hospital treatment for a diagnosed eating disorder were randomly assigned to a treatment group. Measures of working therapeutic alliance, engagement, treatment completion, and clinical impairment were completed at preadmission, mid-treatment, and at the end of treatment.

Results
Working alliance increased equivalently in both conditions over time in treatment. Similarly, there were no differences between conditions in terms of engagement. Regardless of therapy orientation, greater use of the self-help manual predicted lowered eating disorder risk; stronger patient ratings of therapeutic alliance predicted decreased feelings of both ineffectiveness and interpersonal problems.

Conclusion
This pilot RCT provides further evidence that both alliance and engagement are important for treatment of an eating disorder; however, there was no clear advantage of MI over CBT as an adjunctive treatment approach to improving alliance or engagement.
Trial registration: ClinicalTrials.gov ID #NCT03643445 (proactive registration).
GIS-based inventory for safeguarding and promoting Portuguese glazed tiles cultural heritage
Authors: Santos Bertha , Gonçalves Jorge , Almeida Pedro G. , Martins-Nepomuceno Ana M. T. 
Published: June 2023

Abstract
Innovative, non-invasive, digital, and cost-effective instruments for systematic inventory, monitoring and promotion are a valuable resource for managing tangible and intangible cultural heritage. Due to its powerful and effective inventory and analysis potential, which allows supporting central and local entities responsible for cultural heritage management, Geographic Information Systems (GIS) have proven to be an appropriate information technology for developing these kinds of instruments. Given the above, this work aims to introduce a GIS-based instrument to support inventorying, safeguarding, tourism, and cultural promotion of the traditional Portuguese glazed tile (‘azulejo’, in Portuguese) to raise general awareness of the importance of this unique Portuguese heritage. To the best of the authors’ knowledge, there is no other instrument available with inventory and safeguarding management functions that is accessible and affordable, developed to be used at a municipal level and that contributes to the enrichment of the cultural and tourist information. Information from 70 tile works located in the Portuguese city of Covilhã was used to test the proposed GIS tool, resulting in a georeferenced alphanumeric, graphical, image and drawing inventory and in three pedestrian routes for touristic and cultural heritage promotion. The results were validated by both the research team and the municipality of Covilhã, foreseeing its expansion and daily use in the management of the heritage of the traditional Portuguese glazed tile. The proposed instrument can be replicated in other locations and easily implemented and managed by municipalities or institutions dealing with the protection of cultural heritage.
Highly sensitive ultrasound detection using nanofabricated polymer micro-ring resonators
Authors: Lee Youngseop , Zhang Hao F. , Sun Cheng 
Published: June 2023

AbstractPhotoacoustic (PA) imaging enables noninvasive volumetric imaging of biological tissues by capturing the endogenous optical absorption contrast. Conventional ultrasound detectors using piezoelectric materials have been widely used for transducing ultrasound signals into the electrical signals for PA imaging reconstruction. However, their inherent limitations in detection bandwidth and sensitivity per unit area have unfortunately constrained the performance of PA imaging. Optical based ultrasound detection methods emerge to offer very promising solutions. In particular, polymer micro-ring resonators (MRRs) in the form of integrated photonic circuits (IPC) enable significant reduction for the sensing area to 80 μm in diameter, while maintaining highly sensitive ultrasound detection with noise equivalent pressure (NEP) of 0.49 Pa and a broad detection frequency range up to 250 MHz. The continued engineering innovation has further transformed MRRs to be transparent to the light and thus, opens up a wide range of applications, including multi-modality optical microscope with isometric resolution, PA endoscope, photoacoustic computed tomography (PACT), and more. This review article summarizes and discusses the evolution of polymer MRR design and the associated nanofabrication process for improving the performance of ultrasound detection. The resulting novel imaging applications will also be reviewed and discussed.
Acute disseminated encephalomyelitis with optic neuritis and mononeuritis multiplex following COVID-19 vaccination: case report
Authors: Chittilappilly Jomal Mathew , Kaitharath Sholy Vareed 
Published: June 2023

Abstract
Background
Acute disseminated encephalomyelitis (ADEM) is an extremely rare complication of COVID-19 vaccination with very few reports worldwide. Concomitant peripheral nervous tissue involvement in ADEM is very uncommon.

Case presentation
We report the case of a 52 year aged lady who developed headache and focal neurological deficits after 10 days of COVID-19 vaccination. Her evaluation suggested ADEM with optic neuritis and mononeuritis multiplex. She responded to pulse methylprednisolone therapy.

Conclusions
COVID-19 vaccine may be associated with ADEM, optic neuritis and concurrent peripheral nervous system inflammation in rare instances.
A G-type lectin receptor-like kinase in Nicotiana benthamiana enhances resistance to the fungal pathogen Sclerotinia sclerotiorum by complexing with CERK1/LYK4
Authors: Pi Lei , Zhang Yifan , Wang Jinghao , Wang Nan , Yin Zhiyuan , Dou Daolong 
Published: June 2023

AbstractFungal pathogens are among the main destructive microorganisms for crops and ecosystems worldwide, causing substantial agricultural and economic losses. Plant cell surface-localized lysin motif (LysM)-containing receptor-like kinases (RLKs) or receptor-like proteins (RLPs) enhance plant resistance to fungal pathogens via sensing chitin, which is a conserved component of the fungal cell wall. Other types of RLKs also regulate chitin signaling via distinct mechanisms in plants. In this study, we identified a G-type lectin RLK, NbERK1, which positively regulated chitin signaling and resistance to the fungal pathogen Sclerotinia sclerotiorum in the model plant Nicotiana benthamiana. In addition, the LysM-RLK NbCERK1/NbLYK4 was shown to mediate plant resistance to S. sclerotiorum positively. Further, the association of chitin-induced NbCERK1-NbLYK4 was found to be essential for chitin perception and signaling. Importantly, NbERK1 was associated with NbCERK1/NbLYK4 and positively regulated chitin-induced NbCERK1-NbLYK4 association. Moreover, chitin could induce the dissociation of NbERK1 from the NbCERK1-NbLYK4 complex. Also, the kinase activity of NbERK1 was likely essential for this dissociation and plant resistance-enhancing activity of NbERK1. Together, these results suggest that NbERK1 is a novel component of the chitin receptor complex and enhances plant resistance to fungal pathogens via regulating chitin signaling.
Quantum algorithm for the covariance matrix preparation and its application
Authors: Ning T. , Yang Y. L. 
Published: June 2023

Abstract
Performing the eigendecomposition of the covariance matrix of the dataset is of great significance in the field of machine learning. However, classical operations will become time-consuming when involving large data sets. In this paper, in order to address this problem, we design an efficient quantum algorithm to prepare the covariance matrix state by means of quantum amplitude estimation. After that, we research on its application in principal component analysis and Mahalanobis distance calculation. Specifically, we obtain the transformation matrix for quantum principal component analysis based on the singular value estimation algorithm and the amplitude amplification algorithm. Furthermore, we invoke the quantum matrix inversion algorithm to calculate the Mahalanobis distance. The final complexity analysis shows that our proposed algorithms can achieve speedup compared to their classical counterparts under certain conditions.
Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome
Authors: Tora Rana , Welch James , Sun Jian , Agarwal Sunita K , Bell Debra A , Merino Maria , Weinstein Lee S , Simonds William F , Jha Smita 
Published: June 2023

Abstract

Context
Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a heritable form of primary hyperparathyroidism caused by germline inactivating mutations in CDC73 encoding parafibromin and is associated with an increased risk of parathyroid cancer. There is little evidence to guide the management of patients with the disease.

Objective
(1) Characterize the natural history of HPT-JT, (2) correlate genotype and histology of parathyroid tumors with parafibromin immunostaining, (3) understand molecular changes downstream to CDC73 loss.

Design
Retrospective study of patients with HPT-JT syndrome (genetically confirmed or affected first-degree relatives). Independent review of uterine tumor from 2 patients and staining for parafibromin on parathyroid tumors from 19 patients (13 adenomas, 6 carcinomas) was performed. RNA-sequencing was performed in 21 parathyroid samples (8 HPT-JT-related adenomas, 6 HPT-JT-related carcinomas, and 7 sporadic carcinomas with wild-type CDC73).

Results
We identified 68 patients from 29 kindreds with HPT-JT with median age at last follow-up of 39 [interquartile range, 29-53] years. A total of 55/68 (81%) developed primary hyperparathyroidism; 17/55 (31%) had parathyroid carcinoma. Twelve of 32 (38%) females developed uterine tumors. Of the 11 patients who had surgical resection for uterine tumors, 12/24 (50%) tumors were rare mixed epithelial mesenchymal polypoid lesions. Four of 68 patients (6%) developed solid kidney tumors; 3/4 had a CDC73 variant at p.M1 residue. Parafibromin staining of parathyroid tumors did not correlate with tumor histology or genotype. RNA-sequencing showed a significant association of HPT-JT-related parathyroid tumors with transmembrane receptor protein tyrosine kinase signaling pathway, mesodermal commitment pathway, and cell-cell adhesion.

Conclusions
Multiple, recurrent atypical adenomyomatous uterine polyps appear to be enriched in women with HPT-JT and appear characteristic of the disease. Patients with CDC73 variants at p.M1 residue appear predisposed to kidney tumors.

Clinical Trial number
NCT04969926
Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy
Authors: Dineen Rosemary A , Martin-Grace Julie , Ahmed Khalid Mohamed Saeed , Taylor Angela E , Shaheen Fozia , Schiffer Lina , Gilligan Lorna C , Lavery Gareth G , Frizelle Isolda , Gunness Anjuli , Garrahy Aoife , Hannon Anne Marie , Methlie Paal , Eystein Sverre Husebye , Stewart Paul M , Tomlinson Jeremy W , Hawley James M , Keevil Brian G , O’Reilly Michael W , Smith Diarmuid , McDermott John , Healy Marie-Louise , Agha Amar , Pazderska Agnieszka , Gibney James , Behan Lucy-Ann , Thompson Chris J , Arlt Wiebke , Sherlock Mark 
Published: June 2023

Abstract

Background
Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). We hypothesize that corticosteroid metabolism is altered in patients with AI because of the nonphysiological pattern of current immediate release hydrocortisone (IR-HC) replacement therapy. The use of a once-daily dual-release hydrocortisone (DR-HC) preparation, (Plenadren®), offers a more physiological cortisol profile and may alter corticosteroid metabolism in vivo.

Study Design and Methods
Prospective crossover study assessing the impact of 12 weeks of DR-HC on systemic GC metabolism (urinary steroid metabolome profiling), cortisol activation in the liver (cortisone acetate challenge test), and subcutaneous adipose tissue (microdialysis, biopsy for gene expression analysis) in 51 patients with AI (primary and secondary) in comparison to IR-HC treatment and age- and BMI-matched controls.

Results
Patients with AI receiving IR-HC had a higher median 24-hour urinary excretion of cortisol compared with healthy controls (72.1 µg/24 hours [IQR 43.6-124.2] vs 51.9 µg/24 hours [35.5-72.3], P = .02), with lower global activity of 11β-HSD2 and higher 5-alpha reductase activity. Following the switch from IR-HC to DR-HC therapy, there was a significant reduction in urinary cortisol and total GC metabolite excretion, which was most significant in the evening. There was an increase in 11β-HSD2 activity. Hepatic 11β-HSD1 activity was not significantly altered after switching to DR-HC, but there was a significant reduction in the expression and activity of 11β-HSD1 in subcutaneous adipose tissue.

Conclusion
Using comprehensive in vivo techniques, we have demonstrated abnormalities in corticosteroid metabolism in patients with primary and secondary AI receiving IR-HC. This dysregulation of pre-receptor glucocorticoid metabolism results in enhanced glucocorticoid activation in adipose tissue, which was ameliorated by treatment with DR-HC.
Transcriptional bursting: stochasticity in deterministic development
Authors: Leyes Porello Emilia A. , Trudeau Robert T. , Lim Bomyi 
Published: June 2023

ABSTRACT
The transcription of DNA by RNA polymerase occurs as a discontinuous process described as transcriptional bursting. This bursting behavior is observed across species and has been quantified using various stochastic modeling approaches. There is a large body of evidence that suggests the bursts are actively modulated by transcriptional machinery and play a role in regulating developmental processes. Under a commonly used two-state model of transcription, various enhancer-, promoter- and chromatin microenvironment-associated features are found to differentially influence the size and frequency of bursting events – key parameters of the two-state model. Advancement of modeling and analysis tools has revealed that the simple two-state model and associated parameters may not sufficiently characterize the complex relationship between these features. The majority of experimental and modeling findings support the view of bursting as an evolutionarily conserved transcriptional control feature rather than an unintended byproduct of the transcription process. Stochastic transcriptional patterns contribute to enhanced cellular fitness and execution of proper development programs, which posit this mode of transcription as an important feature in developmental gene regulation. In this Review, we present compelling examples of the role of transcriptional bursting in development and explore the question of how stochastic transcription leads to deterministic organism development.
Host species differences in the thermal mismatch of host–parasitoid interactions
Authors: Malinski Katherine H. , Sorenson Clyde E. , Moore M. Elizabeth , Willett Christopher S. , Kingsolver Joel G. 
Published: June 2023

ABSTRACT
Extreme high temperatures associated with climate change can affect species directly, and indirectly through temperature-mediated species interactions. In most host–parasitoid systems, parasitization inevitably kills the host, but differences in heat tolerance between host and parasitoid, and between different hosts, may alter their interactions. Here, we explored the effects of extreme high temperatures on the ecological outcomes – including, in some rare cases, escape from the developmental disruption of parasitism – of the parasitoid wasp, Cotesia congregata, and two co-occurring congeneric larval hosts, Manduca sexta and M. quinquemaculata. Both host species had higher thermal tolerance than C. congregata, resulting in a thermal mismatch characterized by parasitoid (but not host) mortality under extreme high temperatures. Despite parasitoid death at high temperatures, hosts typically remain developmentally disrupted from parasitism. However, high temperatures resulted in a partial developmental recovery from parasitism (reaching the wandering stage at the end of host larval development) in some host individuals, with a significantly higher frequency of this partial developmental recovery in M. quinquemaculata than in M. sexta. Hosts species also differed in their growth and development in the absence of parasitoids, with M. quinquemaculata developing faster and larger at high temperatures relative to M. sexta. Our results demonstrate that co-occurring congeneric species, despite shared environments and phylogenetic histories, can vary in their responses to temperature, parasitism and their interaction, resulting in altered ecological outcomes.
Adherence to Extended Venous Thromboembolism Prophylaxis and Outcomes After Complex Gastrointestinal Oncologic Surgery
Authors: Mavros Michail N. , Johnson Lauren A. , Schootman Mario , Orcutt Sonia T. , Peng Cheng , Martin Bradley C. 
Published: June 2023

Abstract
Background
Clinical guidelines recommend extended venous thromboembolism (VTE) prophylaxis for cancer patients after major gastrointestinal (GI) operations. However, adherence to the guidelines has been low, and the clinical outcomes not well defined.

Methods
This study retrospectively analyzed a random 10 % sample of the 2009–2022 IQVIA LifeLink PharMetrics Plus database, an administrative claims database representative of the commercially insured population of the United States. The study selected cancer patients undergoing major pancreas, liver, gastric, or esophageal surgery. The primary outcomes were 90-day post-discharge VTE and bleeding.

Results
The study identified 2296 unique eligible operations. During the index hospitalization, 52 patients (2.2 %) experienced VTE, 74 patients (3.2 %) had postoperative bleeding, and 140 patients (6.1 %) had a hospital stay of at least 28 days. The remaining 2069 operations comprised 833 pancreatectomies, 664 hepatectomies, 295 gastrectomies, and 277 esophagectomies. The median age of the patients was 49 years, and 44 % were female. Extended VTE prophylaxis prescriptions were filled for 176 patients (10.4 % for pancreas, 8.1 % for liver, 5.8 % for gastric cancer, and 6.5 % for esophageal cancer), and the most used agent was enoxaparin (96 % of the patients). After discharge, VTE occurred for 5.2 % and bleeding for 5.2 % of the patients. The findings showed no association of extended VTE prophylaxis with post-discharge VTE (odds ratio [OR], 1.54; 95 % confidence interval [CI], 0.81–2.96) or bleeding (OR, 0.72, 95 % CI, 0.32–1.61).

Conclusions
The majority of the cancer patients undergoing complex GI surgery did not receive extended VTE prophylaxis according to the current guidelines, and their VTE rate was not higher than for the patients who received it.
Digital transformation of organizations and their organizational cultures. A case study in a national defense industry
Authors: Kapotas Spyridon 
Published: June 2023

Digital transformation has become vital for organizations in order for them to differentiate from competitors providing a competitive advantage in the fast-changing environment they operate. Digital transformation is considered as a radical transformation affecting organization’s products, services, people and processes while improving performance. It is a risky and tremendous challenge for most organizations. Based on a dissertation with the current paper an approach on digital transformation, in a national defense company is attempted. Products and services provided are characterized through high quality standards and a strong culture. Those characteristics are considered a fruitable ground for providing a framework to transform an organization into a digital one. Taking into consideration the above, literature research on digital transformation of organizations and their benefits are provided. The digitalization process is analyzed in order to show the building blocks of transforming the organization into a digital one. However, in order to start such a process, the organization has to have an adaptive high performance organization culture. This is considered as the base to start the digitalization process. In order for the organization to have such a culture, current situation has to be assessed and certain actions to be taken. An assessment of above-mentioned company is presented and actions proposed. It is obvious that organizational digital transformation is inextricably linked with an organizational culture change. The benefits and barriers from such a transformation are shown and finally proposals presented regarding a digital strategy implementation as well as a vision and mission statement for the company.
EL Classifications: M14.
Key words: Digital transformation, digitalization process, digital strategy, organizational culture change, vision and mission statement
The Impact of COVID – 19 First Outbreak on Greek Private High Schools & The Distance Learning Experience
Authors: Malagkoniari Maria , Deliou Cleopatra 
Published: June 2023

Although when we speak of COVID – 19 the main affect concerns the health of individuals, it is clear that the pandemic has also affected many aspects of life such as the educational sector. Both teachers and students in Greece faced the challenge of the implementation of distance learning, national wide, during the pandemic.
There is still a lack of a proper theoretical model and comprehensive scientific tools to measure the impact of COVID – 19 in education. The purpose of this research is to study and analyze whether distance learning affected the Greek private high schools in different ways such as in terms of students’ graduation or their success rate in the PanHellenic Exams, during the first outbreak of the COVID-19 pandemic.
Based on literature and feedback received from high schools’ principals we captured important results over the use of distance learning and its effectiveness. More specifically, through the quantitative study performed on 63 out of 79 private high schools’ principals, the researchers reached the conclusion that the majority of private schools managed distance education successfully. It was proved that both teaching and administrative staff were highly competent and skilled in the use of new technologies and therefore, distance education was not treated as a problematic situation but it steadily became part of each school’s daily routine.

EL Classifications: Μ19 (M: Business Administration and Business Economics/ Marketing/ Accounting/ Personnel Economics – Μ1: Business Administration – M19: Others)

Key words: Distance Education, COVID – 19 Pandemic, Greek Private High Schools, Principals