bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amelioration of Autoimmunity in a Lupus Mouse Model by Modulation of T‐Bet–Promoted Energy Metabolism in Pathogenic Age/Autoimmune‐Associated B Cells
Authors: Han Xiaxia , Gu Shuangshuang , Hong Soon‐Min , Jiang Yang , Zhang Jinsong , Yao Chao , Yin Zhihua , Ye Zhizhong , Ding Huihua , Chen Sheng , Dai Dai , Shen Nan 
Published: December 2022

ObjectiveEmerging evidence indicates that a distinct CD11c+T‐bet+ B cell subset, termed age/autoimmune‐associated B cells (ABCs), is the major pathogenic autoantibody producer in lupus. Human lupus is associated with significant metabolic alterations, but how ABCs orchestrate their typical transcription factors and metabolic programs to meet specific functional requirements is unclear. We undertook this study to characterize the metabolism of ABCs and to identify the regulators of their metabolic pathways in an effort to develop new therapies for ABC‐mediated autoimmunity.MethodsWe developed a T‐bet–tdTomato reporter mouse strain to trace live T‐bet+ B cells and adoptively transferred CD4+ T cells from bm12 mice to induce lupus. We next sorted CD11c+tdTomato+ B cells and conducted RNA sequencing and an extracellular flux assay. A metabolic restriction to constrain ABC formation was tested in human and mouse B cells. We used a bm12‐induced lupus mouse model to conduct the metabolic intervention.ResultsABCs exhibited a hypermetabolic state with enhanced glycolytic capacity. The increased glycolytic rate in ABCs was promoted by interferon‐γ (IFNγ) signaling. T‐bet, a downstream transcription factor of IFNγ, regulated the gene program of the glycolysis pathway in ABCs by repressing the expression of Bcl6. Functionally, glycolysis restriction could impair ABC formation. The engagement of glycolysis promoted survival and terminal differentiation of antibody‐secreting cells. Administration of a glycolysis inhibitor ameliorated ABC accumulation and autoantibody production in the lupus‐induced bm12 mouse model.ConclusionT‐bet can couple immune signals and metabolic programming to establish pathogenic ABC formation and functional capacities. Modulation of ABCs favored a metabolic program that could be a novel therapeutic approach for lupus.image
Open Loop Recycling – Guanidine Iron(II) Polymerization Catalyst for the Depolymerization of Polylactide
Authors: Burkart Lisa , Eith Alexander , Hoffmann Alexander , Herres‐Pawlis Sonja 
Published: December 2022

AbstractA previously reported non‐toxic guanidine‐iron catalyst active in the ring opening polymerization (ROP) of polylactide (PLA) under industrially relevant conditions was evaluated for its activity in the alcoholysis and aminolysis of PLA under mild conditions. Kinetic and thermodynamic parameters were determined for the methanolysis of PLA with [FeCl2(TMG5NMe2asme)] (C1) using 1H NMR spectroscopy. A comparison with the Zn analog of C1 showed that the metal center has a large impact on the activity for the alcoholysis. Further, the influence of different nucleophiles was tested broadening the scope of products from PLA waste. C1 is the first discrete metal catalyst reported to be active in the selective aminolysis of PLA. Catalyst recycling, scale‐up experiments and solvent‐free alcoholysis were conducted successfully strengthening the industrial relevance and highlighting aspects of green chemistry. Moreover, the selective depolymerization of PLA in polymer blends was successful. C1 is a promising catalyst for a circular (bio)plastics economy.
Collagen‐coated agarose–chitosan scaffold used as a skin substitute
Authors: Sang Shengbo , Zhao Yajing , Shen Zhizhong , Cao Yanyan , Cheng Rong , Yan Yayun , Jian Aoqun , Wang Jianming 
Published: December 2022

AbstractA single biomaterial is disadvantageous for constructing skin in vitro, so a mixed biomaterial is more conducive to skin research. In this study, agarose–chitosan scaffolds with a final concentration of 4% were constructed by freeze‐drying, in which the concentration ratios of agarose to chitosan were 1:3, 2:2, and 3:1. The scaffolds were coated with a 3 mg/ml collagen solution, and the mechanical properties were evaluated by studying density, porosity, swelling rate, and degradation rate. The results demonstrated that the agarose–chitosan scaffolds were porous, with porosity reaching 93%. Their densities ranged from 0.1 to 0.16 g/cm3. Analysis of Young's modulus showed that the mechanical properties of the agarose–chitosan scaffolds were significantly enhanced when the agarose content in the agarose–chitosan scaffolds was increased. Moreover, the density and Young's modulus of the agarose–chitosan scaffolds of different concentration ratios were significantly different (p < 0.01). These scaffolds can withstand a certain amount of external pressure, such as that of human skin, making them more suitable for further skin replacement research. In addition, the results of thiazolyl blue tetrazolium bromide (MTT) cell assay and immunofluorescence staining showed that the collagen‐coated agarose–chitosan scaffolds were conducive to keratinocyte proliferation and differentiation. The MTT results revealed significant differences between the agarose–chitosan scaffolds coated with collagen and the agarose–chitosan scaffolds without collagen (p < 0.05). This study provides the potential for in vitro skin research and applications.
Rapid identification of methicillin‐resistant Staphylococcus aureus by MALDI‐TOF MS: A meta‐analysis
Authors: Chen Chaoqun , Zhou Zheng , Cong Liu , Shan Mingzhu , Zhu Zuobin , Li Ying 
Published: December 2022

AbstractInvasive infections caused by methicillin‐resistant Staphylococcus aureus (MRSA) are associated with high mortality and morbidity. The sooner the pathogen is determined, the better it is beneficial to patient. However, routine laboratory inspections are time‐consuming and laborious. A thorough research was conducted in PubMed and Web of Science (until June 2021) to identify studies evaluating the accuracy of MRSA identification by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS). STATA 15.0 software was used to analyze the pooled results of sensitivity, specificity, and 95% confidence intervals (CI). The summary receiver operating characteristic curves (SROC) and area under the curve (AUC) were utilized to show the overall performance of MALDI‐TOF MS. Fifteen studies involving 2471 isolates were included in this study after the final selection in this meta‐analysis. Using the random effects model forest plot to summarize the overall statistics, the sensitivity of MALDI‐TOF MS for identifying MRSA was 92% (95% CI: 81%–97%), and the specificity was 97% (95% CI: 89%–99%). In the SROC curve, the AUC reached 0.99 (95% CI: 97%–99%). Deeks’ test showed no significant publication bias in this meta‐analysis. Compared with clinical reference methods, MALDI‐TOF MS identification of MRSA shows a higher degree of sensitivity and specificity.
Comparison of production of gamma‐decalactone via microbial biotransformation based on different adsorption‐embedding systems
Authors: Chen Julong , Tang Yuxin , Zhang Shuo 
Published: December 2022

AbstractGamma‐decalactone (GDL) is an essential flavor additive with peach‐aroma, which can be prepared via microbial biotransformation from ricinoleic acid (RA). The difficulty of RA dispersion in medium limited its utilization, which made the yield of GDL low. In this study, four adsorbent materials (AM) were investigated to increase RA distribution, including halloysite, clay, SUNSIL‐130NP silica (130NP), and SUNSIL‐130H silica (130H). They were compared with respect to their effects on the biotransformation process, and the mechanism of AM on productivity of Saccharomyces cerevisiae was revealed. Scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis were utilized to reveal the mechanism of AM effect on GDL production. The results showed that AM functioned as an adsorption and slow‐releasing carrier of RA and cell immobilization. RA was crosslinked onto the surface of four AM via hydrogen bonds and the contact area between RA and yeast increased without negative viability effect. The best adsorption‐embedding rate of RA to AM was 70.94% with 130H and the GDL yield improved to 2.79 g L−1. The highest conversion rate was 88.99% with halloysite at 36 h. This study provides a potential strategy to improve GDL yield efficiently via biotransformation on an industrial scale.
Effects of economic regional differences and family on adolescents’ aggressive behaviors: Perspective of ecosystem integration
Authors: Hong Xinwei , Liu Shen , Fan Hang , Xie Hongwei , Fang Shengjie , Zhang Lin 
Published: December 2022

AbstractIntroductionBased on the ecological systems theory and cumulative risk model, the current study aimed to determine the mediating effects of parenting styles, peer relationship, and psychological capital on family socioeconomic status and adolescents’ aggressive behaviors, as well as the moderating effects of economic regional differences.MethodsIn a cross‐sectional design, 1271 Chinese adolescents were recruited to complete the MacArthur Scale, the short‐form Egna Minnen av Barndoms Uppfostran, the Positive PsyCap Questionnaire, the peer support subscale in the Student Personal Perception of Classroom Climate, and the Aggression Questionnaire.ResultsAfter controlling for gender and age, parenting style, peer relationship, and psychological capital not only mediated, but also constituted multiple chains mediation between family socioeconomic status and aggressive behaviors. Moreover, economic regional differences moderated the multiple chains mediation model between family socioeconomic status and aggressive behaviors.ConclusionThe accumulation of multiple adverse factors increases the probability of inducing aggressive behaviors, and the development of psychological capital helps reduce the occurrence of aggressive behaviors in adolescents.
Schwannomas mistaken for metastases of melanoma in PET‐CT: A diagnostic challenge with consequences
Authors: Hirsiger Stefanie , Olariu Radu 
Published: December 2022

AbstractThe incidence of skin cancer and especially cutaneous malignant melanoma is rising, as are indications for staging examinations to detect metastasis. Schwannomas are common benign nerve tumors, which can be mistaken for metastasis even in highly specialized imaging. Risk of nerve lesion is high in inadvertent biopsy.
Treacher Collins syndrome: A case report and review of literature
Authors: Kolsi Nadia , Boudaya Fatma , Ben Thabet Afef , Charfi Manel , Regaieg Chiraz , Bouraoui Amira , Regaieg Ridha , Hentati Nedia , Hamed Amel Ben , Gargouri Abdellatif 
Published: December 2022

AbstractTreacher Collins syndrome (TCS) is one of the rare genetic syndromes which is specified by symmetrical craniofacial dysmorphism without growth abnormalities or neurological disorders. The inheritance is usually autosomal dominant but sometimes it is a sporadic mutation. Prenatal diagnosis could be realized by genetic testing of a chorionic villus sample or amniocentesis if one of the parents is affected. At birth, the most common features are downward‐sloping palpebral clefts, small badly hemmed and folded ears, and mandibular hypoplasia which could lead to respiratory distress. All of these clinical features exist in our case. Goldenhar syndrome shares with TCS some facial features which are not symmetrical and it is also associated with vertebral abnormalities. Some patients with TCS are exposed to many complications and they require multi‐disciplinary medical care. But all of them need psychiatric care to fight social rejection. The aim of our report is to describe the most common features of TCS and similar syndromes. Also, report the involved genetic mutations, some associated complications, and their management.
Cerebral venous thrombosis in a patient with adenomyosis: A case report
Authors: Yadav Jayant Kumar , Thapa Aakar , Bhattarai Anjan , KC Ashmita , Budhathoki Samip Jung , Chandra Avinash , Rajbhandari Reema 
Published: December 2022

AbstractCerebral venous thrombosis can be caused by different conditions such as infectious, structural, hypercoagulable states, hematological, hormonal, collagen, vascular diseases, and oral contraceptive pills among other causes. Adenomyosis has been rarely associated with Cerebral venous thrombosis (CVT). Increased CA‐125 and iron deficiency anemia in adenomyosis may predispose to CVT.
Early amiodarone pneumonitis: A case report
Authors: Soleimani Abbas , Bavandpour Karvane Houshang , Mortezazadeh Masoud , Mofidi Abbas , Seyyed Mahmoudi Seyyed Taher , Kashani Mehdi 
Published: December 2022

AbstractConsider amiodarone pneumonitis as an important differential diagnosis of ARDS, especially in clinically ill patients who recently received Intravenous amiodarone.
Electrochemical Hydrodimerization of Furfural in Organic Media as an Efficient Route to Jet Fuel Precursor
Authors: Temnikova Maria , Medvedev Jury , Medvedeva Xenia , Delva Nyhenflore H. , Khairullina Evgeniia , Krivoshapkina Elena , Klinkova Anna 
Published: December 2022

AbstractUpgrading biomass‐derived compounds to value‐added products, especially fuels, represents a green route alternative to fossil fuels energy sources. Here, we report an efficient electrosynthesis of a jet fuel precursor hydrofuroin from furfural, which is one of the most valuable compounds derived from biomass. Despite the high value of this process, few studies have been focused on the development of synthetic strategies for electrocatalytic hydrodimerization of furfural to hydrofuroin. In this work, we systematically examine how operating parameters, including the electrolyte, applied potential, furfural concentration, and catalyst nature affect the efficiency of hydrofuroin electrosynthesis in organic media. We show that under the optimized conditions, the electrosynthesis can be carried out in a simple undivided cell with a high faradaic efficiency (up to 74 %) and an excellent hydrofuroin yield (up to 100 %).
Probing the Na+/Li+‐ions Insertion Mechanism in an Aqueous Mixed‐Ion Rechargeable Batteries with NASICON‐NaTi2(PO4)3 Anode and Olivine‐LiFePO4 Cathode
Authors: Venkatesha Akshatha , Seth Deepak , Varma Rahul Mahavir , Das Suman , Agarwal Manish , Haider M. Ali , Bhattacharyya Aninda J. 
Published: December 2022

AbstractAqueous rechargeable mixed‐ion batteries (ARMBs), where two types of ions shuttle between the cathode and anode, are an important alternative to conventional non‐aqueous electrolyte‐based rechargeable batteries. Herein, we present fundamental insights into the function of an ARMB comprising of NASICON‐based sodium titanium phosphate (NaTi2(PO4)3/NTP) and olivine‐based lithium iron phosphate (LiFePO4/LFP) employed as the anode and cathode respectively in combination with mixed‐ion electrolytes, x‐M Li2SO4: y‐M Na2SO4 (x+y=1). Electrochemical and ex situ structural studies interestingly reveal a preferential Na+‐ion insertion into NTP, despite the presence of two different cations in the electrolyte. This is strongly supported by molecular dynamics simulations, which show a 1–2 orders higher diffusion coefficient for Na+‐ion than Li+‐ion in NTP. In contrast, co‐insertion of Li+ and Na+‐ions into LFP takes place when cycled in mixed‐ion electrolytes. We also show that batteries with mixed‐ion electrolytes perform better than electrolytes with individual cations.
Mindfulness for the self‐management of negative coping, rumination and fears of compassion in people with cancer: An exploratory study
Authors: Williams Sian , Clarke Seraphine , Edginton Trudi 
Published: December 2022

AbstractBackgroundCancer and its treatments have the potential to significantly impact mental health, provoking feelings of anxiety, depression, and distress, which can last long after treatment is over. One of the most rapidly emerging influences in the healthcare field is mindfulness‐based interventions (MBIs), which are designed to cultivate present moment awareness, attentional flexibility, compassion and acceptance, to reduce physical and psychological distress. However, there is limited research into the efficacy of MBIs or disease specific MBIs in shifting negative coping, ruminative thinking and fears of compassion as primary outcomes in individuals with cancer.AimsThis exploratory study was designed to evaluate inter‐ and intra‐individual change in the management of negative coping, rumination and fears of compassion, following a cancer‐specific mindfulness‐based intervention.Methods and ResultsA single group, non‐experimental, repeated measures study of 22 participants across six cancer care centres explored the efficacy of an 8‐week Mindfulness‐Based Cognitive Therapy for Cancer (MBCT‐Ca) course. The Reliable Change Index (RCI) examined reliable clinical improvement, deterioration, or no change in individuals on the Mental Adjustment to Cancer Scale (MACS), the Ruminative Responses Scale (RRS) and the Fears of Compassion Scale (FCS). About 82% of participants (n = 18) saw an improvement in at least one measure. A significant decrease in primary outcome scores was observed in negative coping, ruminating and fears of self‐compassion. There were significant correlations between the fear of self‐compassion and depressive ruminating, fear of accepting compassion from others and showing it to others pre and post intervention.ConclusionOur findings indicate that the MBCT‐Ca programme may significantly reduce negative coping, ruminating and fears of self‐compassion improving psychological health and wellbeing in cancer survivors.
Graphitic Carbon Nitride Based Materials Towards Photoproduction of H2O2
Authors: Vuong Hoai‐Thanh , Bui Dai‐Phat , Nguyen Duc‐Viet , Pho Phuong Ly , Duc Minh Phan Pham , Do Dat Tran , Hieu Nguyen Huu 
Published: December 2022

AbstractHydrogen peroxide (H2O2) can be considered as one of the world's indispensable chemicals. However, the synthetic process can prompt several severe environmental and human health issues. However, solar H2O2 production may provide opportunities to mitigate such issues. Graphitic carbon nitride (g‐C3N4) has emerged as one promising material for photocatalytic applications due to its unique properties. Although tremendous efforts in engineering g‐C3N4 have been proposed to improve catalytic results, the materials obtained still have some issues. Additionally, the mechanisms behind the production of H2O2 by using such materials are not yet fully understood. Herein, we conducted a literature survey reviewing the production of H2O2 using g‐C3N4‐based materials. The essential aspects of and current challenges in photocatalytic H2O2 generation are discussed, which may provide insight for researchers to overcome barriers and develop sustainable methods for H2O2 production.
The Implications of Coupling an Electron Transfer Mediated Oxidation with a Proton Coupled Electron Transfer Reduction in Hybrid Water Electrolysis
Authors: Mondal Biswajit , Dinda Soumitra , Karjule Neeta , Mondal Sanjit , Raja Kottaichamy Alagar , Volokh Michael , Shalom Menny 
Published: December 2022

AbstractElectrolysis of water is a sustainable route to produce clean hydrogen. Full water‐splitting requires a high applied potential, in part because of the pH‐dependency of the H2 and O2 evolution reactions (HER and OER), which are proton‐coupled electron transfer (PCET) reactions. Therefore, the minimum required potential will not change at different pHs. TEMPO [(2,2,6,6‐tetramethyl‐1‐piperidin‐1‐yl)oxyl], a stable free‐radical that undergoes fast electro‐oxidation by a single‐electron transfer (ET) process, is pH‐independent. Here, we show that the combination of PCET and ET processes enables hydrogen production from water at low cell potentials below the theoretical value for full water‐splitting by simple pH adjustment. As a case study, we combined the HER with the oxidation of benzylamine by anodically oxidized TEMPO. The pH‐independent electrocatalytic oxidation of TEMPO permits the operation of a hybrid water‐splitting cell that shows promise to perform at a low cell potential (≈1 V) and neutral pH conditions.
Spatial scale selection for informing species conservation in a changing landscape
Authors: Monroe Adrian P. , Heinrichs Julie A. , Whipple Ashley L. , O'Donnell Michael S. , Edmunds David R. , Aldridge Cameron L. 
Published: December 2022

AbstractIdentifying the relevant spatial scale at which species respond to features in a landscape (scale of effect) is a pressing research need as managers work to reduce biodiversity loss amid a variety of environmental challenges. Until recently, researchers often evaluated a subset of potential scales of effect inferred from previous studies in other locations, often based on different biological responses and environmental variables. These approaches, however, can create uncertainty as to whether relevant spatial scales were identified, and whether the effects of environmental variables at scale were accurately estimated. Identifying scales of effect is particularly relevant for the greater sage‐grouse (Centrocercus urophasianus), a sagebrush‐obligate species of conservation concern requiring large areas of intact sagebrush cover (Artemisia spp.) for habitat. We demonstrate the application of a scale selection approach that jointly estimates the scale of effect and the effect of sagebrush cover on trends in population size using counts from 584 sage‐grouse leks in southwestern Wyoming (2003–2019) and annual estimates of sagebrush cover from a remote sensing product. From this approach, we estimated a positive effect of mean sagebrush cover with a 95% probability that the scale of effect occurred within 5.02 km of leks. In an average year, we found that lower levels of sagebrush cover within these estimated scales could support increasing trends in sage‐grouse population size when populations were small, but higher levels of sagebrush cover were needed to sustain growing populations when populations were larger. With standardized monitoring and annual estimates of vegetation from remote sensing, this scale selection approach can be applied to identify relevant scales for other populations, species, and biological responses such as demography and movement.
Expecting exclusion: Does bracing for the worst buffer the pain of social exclusion?
Authors: Jauch Melissa , Büttner Christiane M. , Rudert Selma C. , Greifeneder Rainer 
Published: December 2022

AbstractEvidence from different research areas suggests that expecting negative outcomes can buffer their adverse psychological effects. In the context of social exclusion, however, evidence for buffering effects of expectations on individuals’ immediate need threat is mixed and has not been examined in terms of cognitive bracing. We present four studies (N = 1159) that test two competing hypotheses (no buffering vs. buffering effects) and focus on three explanations that may account for the previous mixed findings. Study 1 provides support for buffering effects. However, Studies 2, 3 and 4 do not replicate these effects. An integrative data analysis across the four studies using equivalence tests suggests no meaningful differences in need threat after exclusion. These results suggest that expectations alone may not suffice to buffer immediate need threat or negative affect after exclusion, and illuminate how prior seemingly contradictory evidence may align well. Conceptual and practical implications are discussed.