bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heavy Oil Late Life Energy Recovery—Maximizing the Value of Mature Thermal Assets
Authors: Beentjes Ivan , Bogatkov Dmitry 
Published: March 2023

AbstractThe Heavy Oil Late Life Energy Recovery (HOLLER) project is the application of geothermal technology in steam assisted gravity drainage (SAGD) wells that are near end of life. While conventional geothermal technology is encumbered by the high cost of drilling deep wells to reach formations with the temperatures required for economic power generation, in situ bitumen producers have access to existing SAGD wells within mature reservoirs that are at shallow depths and high temperatures. The thermal energy from just one SAGD well can produce enough electricity to power thousands of homes for a year and major oilsands producers collectively have thousands of such wells.Our goal is to harness this thermal energy using the existing well inventory to create a closed geothermal system using process effluent water (PEW) such as boiler blowdown or tailings pond water as the heat recovery medium. This strategy has the potential to improve SAGD economics through incremental bitumen recovery, the generation of low-carbon base load electricity, and driving down SAGD greenhouse gas (GHG) emissions by recovering some of the spent energy. This strategy also provides an option to dispose process water and/or tailings water to accelerate the reclamation of tailings ponds. Suncor’s In Situ Technology team applied a stage-gated technology development process to progress HOLLER from Technology Readiness Level (TRL) 0—Idea to TRL 7—Field test. We applied the diverge-converge approach to 30 ideas that were distilled into four recommended commercial solutions. Our de-risking activities include numerical reservoir simulation, chemical process simulation, post-SAGD core and water analysis, laboratory studies for compatibility of various PEW sources with reservoir fluids and rock, core flooding, corrosion studies, facility design, economics, risk and uncertainty analysis, patenting, and testing in the field.As a result of the technology development work, we have developed a three-phase strategy to maximize the value of depleted in situ reservoirs: water disposal, energy recovery and permanent closure. This strategy offers synergies between mining and in situ operations, reduction in GHG emissions and environmental liabilities all while generating a net profit for the enterprise. If applied industry-wide, HOLLER technology has the potential of reducing not only the intensity, but also the absolute GHG emissions, while offering unique opportunities for collaboration between the in situ producers and mining operations.HOLLER is unique in its potential to retroactively reduce the GHG intensity of bitumen already recovered by thermal methods. It offers low emissions incremental bitumen production, nearly emissions-free power generation, increased efficiency of existing facilities through the direct use of recovered heat – while reducing mine tailings liabilities. HOLLER enhances the oilsands industry’s sustainability efforts.
Modeling Two-Phase Flow in Tight Core Plugs with an Application for Relative Permeability Measurement
Authors: Yousefi M. , Dehghanpour H. 
Published: March 2023

Summary
The two-phase flow of immiscible fluids in porous media has been studied for a long time in different disciplines of engineering. Relative permeability (kr) is one of the constitutional relationships in the general equation governing immiscible displacement that needs to be determined. Due to the complexity and nonlinear nature of governing equations of the problem, there is no unique model for relative permeability. The modified Brooks and Corey (MBC) model is the most common model for kr prediction. Here, a practical technique is presented to measure kr for low-permeability tight rocks. We use this experimental data to tune the empirical constants of the MBC model. The proposed method is based on a simple mathematical technique that uses assumptions of frontal advance theory to model the pressure drop along the core plug during two-phase immiscible displacement at constant injection flow rate. We make simplifying assumptions about the highest point on the observed pressure profile and use those assumptions to determine relative permeability of a tight rock sample. In the end, the amount of work for an immiscible displacement is calculated as the area under the pressure-profile curve. The effect of initial water saturation (Swi) and interfacial tension (IFT) is studied on the work required for an immiscible displacement. Using this concept, it is concluded that adding chemical additives such as surfactants to fracturing fluids can help the reservoir oil to remove the water blockage out of the rock matrix more easily while maintaining the flow rate at an economic level.
Revealing the Reversible Solid-State Electrochemistry of Lithium-Containing Conjugated Oximates: Towards a New Functionality for Organic Batteries
Authors: Wang Jiande , Apostol Petru , Rambabu Darsi , Liu Xuelian , Guo Xiaolong , Robeyns Koen , Lakraychi Alae Eddine , Morari Cristian , Gohy Jean-Francois , Gupta Deepak , Vlad Alexandru 
Published: March 2023

Abstract
In the rising advent of organic Li-ion positive electrode materials with increased energy content, chemistries with high redox potential and intrinsic oxidation stability, while in the lithium containing (Li-ion) form, remain a challenge. Molecular engineering of carbonyl compounds and of conjugated sulfonamide chemistries, have provided ground for future developments, while also inciting the search for other organic chemistry functions or classes, with alike properties, and with further improved energy storage metrics. Herein, we report on the solid- phase reversible electrochemistry of a new class of organic redox functionality for batteries, the lithium salts of conjugated oximates. The disclosed first five examples of the oximate class, including cyclic (aromatic), and acyclic (non-aromatic), as well as aliphatic and tetra-functional stereotypes, uncover the complex interplay between the molecular structure and the electroactivity, as well as the potential of this rich family as Li-ion positive electrode materials for batteries. Amongst the exotic features specific to this class of materials, the most appealing one is the reversible electrochemical polymerization – depolymerization accompanying the charge storage process in solid phase, through intermolecular azodioxy coupling (-ONNO-) or the intramolecular furoxan cyclization of the oxidized forms. Over the disclosed materials, the best performing candidate delivers a high reversible capacity of 350 mAh g-1 at an average potential of 3.0 vs. Li+/Li0, attaining 1 kWh kg-1 specific energy content at the material level metric. This work ascertains a strong link between the electrochemistry, organic chemistry and battery science by emphasizing on how different phases, mechanisms and performances can be accessed using a single chemical functionality.
Utility-based accessibility to evaluate transport policies in Latin America
Authors: Guzman Luis A. , Cantillo-Garcia Victor A. , Oviedo Daniel , Arellana Julian 
Published: March 2023

Abstract
There is now a long tradition of accessibility research in Latin American cities, with an increasingly rich set of frameworks and methods from a distributional perspective. Despite such a positive outlook, most accessibility metrics deployed in research and practice do not consider the dimension of (dis)utility, which resonates more clearly with mainstream transport decision-making and planning. This paper seeks to contribute to debates about the use of utility-based measures as inputs for accessibility assessment of transport infrastructure investments in the Global South using discrete choice modeling and its potential as a bridging language between socially nuanced and economics-driven transport planning practices. This paper uses mixed revealed preferences and stated preferences data collected in Bogotá, Colombia. Then, it uses a logsum accessibility metric to estimate the differentiated impact of a set of infrastructure interventions on the accessibility of residents with different income levels and other socioeconomic conditions for accessing opportunities in the city. Particularly, the logsum accessibility metric analyses future innovations and structural additions to Bogotá public transport networks reflecting their effect on the accessibility and consumer surplus in the next 20 years. The proposed approach captures the benefits derived from the opportunity locations and transport infrastructure improvements, which has relevance for debates about transport policy and practice in this and similar urban contexts in the Global South. These accessibility gains could be assigned a monetary value to include in project cost-benefit assessments.
InSpectra – A Platform for Identifying Emerging Chemical Threats
Authors: Feraud Mathieu , O'Brien Jake , Samanipour Saer , Dewapriya Pradeep , Herwerden Denice van , Kaserzon Sarit , Wood Ian , Rauert Cassandra , Thomas Kevin 
Published: March 2023

Abstract
Non-target analysis (NTA) employing high-resolution mass spectrometry (HRMS) coupled with liquid chromatography is increasingly being used to identify chemicals of biological relevance. HRMS datasets are large and complex making the identification of potentially relevant chemicals extremely challenging. As they are recorded in vendor-specific formats, interpreting them is often reliant on vendor-specific software that may not accommodate the advancements in data processing. Here we present InSpectra, a vendor independent automated platform for the systematic detection of newly identified emerging chemical threats.InSpectra is web-based, open-source/access and modular providing highly flexible and extensible NTA and suspect screening workflows. As a cloud-based platform, InSpectra exploits parallel computing and big data archiving capabilities with a focus for sharing and community curation of HRMS data. InSpectra offers a reproducible and transparent approach for the identification, tracking and prioritisation of emerging chemical threats.
Comparing genomes recovered from time-series metagenomes using long- and short-read sequencing technologies
Authors: Orellana Luis H. , Krüger Karen , Sidhu Chandni , Amann Rudolf 
Published: March 2023

Abstract
Background
Over the past years, sequencing technologies have expanded our ability to examine novel microbial metabolisms and diversity previously obscured by isolation approaches. Long-read sequencing promises to revolutionize the metagenomic field and recover less fragmented genomes from environmental samples. Nonetheless, how to best benefit from long-read sequencing and whether long-read sequencing can provide recovered genomes of similar characteristics as short-read approaches remains unclear.
Results
We recovered metagenome-assembled genomes (MAGs) from the free-living fraction at four-time points during a spring bloom in the North Sea. The taxonomic composition of all MAGs recovered was comparable between technologies. However, differences consisted of higher sequencing depth for contigs and higher genome population diversity in short-read compared to long-read metagenomes. When pairing population genomes recovered from both sequencing approaches that shared ≥ 99% average nucleotide identity, long-read MAGs were composed of fewer contigs, a higher N50, and a higher number of predicted genes when compared to short-read MAGs. Moreover, 88% of the total long-read MAGs carried a 16S rRNA gene compared to only 23% of MAGs recovered from short-read metagenomes. Relative abundances for population genomes recovered using both technologies were similar, although disagreements were observed for high and low GC content MAGs.
Conclusions
Our results highlight that short-read technologies recovered more MAGs and a higher number of species than long-read due to an overall higher sequencing depth. Long-read samples produced higher quality MAGs and similar species composition compared to short-read sequencing. Differences in the GC content recovered by each sequencing technology resulted in divergences in the diversity recovered and relative abundance of MAGs within the GC content boundaries.
Sexual dysfunction at 3 and 6 months postpartum. A sub-analisys of the Perineal Massage and Warm Compresses technique during second stage of labor randomized controllled trial (PeMWaC)
Authors: Rodrigues Silvia , Silva Paulo Manuel Marques da , de Sousa Natacha Quintal , Monterroso Ligia , Escuriet Ramon 
Published: March 2023

Abstract
Purpose: Childbirth is a known risk factor for postpartum sexual dysfunction. Perineal massage and warm compresses technique during second stage of labor could reduce perineal trauma. However, women experience perineal pain and dyspareunia regardless of the presence or absence of perineal trauma after spontaneous vaginal birth. Although the influence of this perineal technique protection in sexual dysfunction never was investigated. Compare postpartum sexual function in women undergoing combined perineal massage and warm compresses and those undergoing hands-on technique during second stage of labor.
Methods: An randomised controlled trial (PeMWaC - Perineal Massage and Warm Compresses) was enrolled at Hospital of Braga from March 1st, 2019 to December 31st, 2020. Eight hundred forty eight women were recruited, of whom 496 (62%) completed the Female Sexual Function Index (FSFI) at 3 and 6 months postpartum. A sub-analisys of primary data was performed to assess postpartum sexual dysfunction the FSFI Score was applied at 3 and 6 months postpartum. Sexual dysfunction was defined by FSFI score <26.55.
Results: At 3 months postpartum, overall FSFI scores were not statistically different between the intervention and control groups. When evaluating by each FSFI domain, satisfaction domain had significant lower scores in satisfaction (p=0.048) at 3 months postpartum. At 6 months postpartum, overall FSFI scores were not statistically different between the intervention and control groups. The perineal trauma in relation to perineal protection techniques was not significantly associated with sexual dysfunction at 3 and 6 months postpartum. FSFI scores at 3 or 6 months postpartum was not statistically different between exclusive breastfeed and not exclusive breastfeed women.
Conclusion: PeMWac was not associated with postpartum sexual dysfunction.
Multi-spatial scale land use land cover influences on seasonally dominant water quality along Middle Ganga Basin
Authors: Krishnaraj Ashwitha , Honnasiddaiah Ramesh 
Published: March 2023

Abstract
In this study, we compared catchment, riparian, and reach scale models to assess the effect of LULC on WQ. Using various multivariate techniques, a 14-year data set of 20 WQ variables from 20 monitoring stations (67,200 observations) is studied along the Middle Ganga Basin (MGB). Based on the similarity and dissimilarity of WQPs, the k-means clustering algorithm classified the 20 monitoring stations into four clusters. Seasonally, the three PCs chosen explained 75.69% and 75% of the variance in the data. With PCs > 0.70, the variables EC, pH, Temp, TDS, NO2 + NO3, P-Tot, BOD, COD, and DO have been identified as dominant pollution sources. The applied RDA analysis revealed that LULC has a moderate to strong contribution to WQPs during the wet season but not during the dry season. Furthermore, dense vegetation is critical for keeping water clean, whereas agriculture, barren land and build-up area degrade WQ. Besides that, the findings suggest that the relationship between WQPs and LULC differs at different scales. The stacked ensemble regression (SER) model is applied to understand the model's predictive power across different clusters and scales. Overall, the results indicate that the riparian scale is more predictive than the watershed and reach scales.
Isolation and characterization of a neoxanthin synthase gene functioning in fucoxanthin biosynthesis of Phaeodactyum tricornutum
Authors: Sui J. K. , Zhang Z. Y. , Han J. C. , Yang G. P. , Liu T. Z. , Wang H. 
Published: March 2023

Abstract
Golden-brown xanthophyll fucoxanthin in marine organisms, especially in diatoms, has attracted widespread attention because of its diverse biological activities. However, the biosynthetic pathway of fucoxanthin remains unclear in diatoms. Fucoxanthin may derive from either neoxanthin or diadinoxanthin pathways. However, the key point is whether neoxanthin and its synthesizing genes exist or not. In this study, we successfully identified a few xanthophylls in trace amounts in the concentrated fraction of carotenoids of diatom cultured at different light intensities with the co-chromatography method and cloned the neoxanthin synthase (NXS) gene which was not annotated in diatom genome. The NXS knockdown and knockout experiments show a positive correlation in the accumulation of neoxanthin and zeaxanthin while a negative correlation in violaxanthin and fucoxanthin with the expression of NXS. In vitro assay evidenced that neoxanthin is the precursor for fucoxanthin biosynthesis, indicating that other molecules intermediate the conversion between violaxanthin and fucoxanthin. Overall, we cloned a novel gene functioning in neoxanthin biosynthesis, which should aid in clarifying the fucoxanthin biosynthetic pathway in diatom.
Vietnamese health professionals’ views on the status of the fetus and maternal and fetal health interests: A regional, cross-sectional study from the Hanoi area
Authors: Mogren Ingrid , Lan Pham Thi , Phuc Ho Dang , Holmlund Sophia , Small Rhonda , Ntaganira Joseph , Sengoma Jean Paul Semasaka , Kidanto Hussein Lesio , Ngarina Matilda , Bergström Cecilia 
Published: March 2023

Abstract
Background: Obstetric ultrasound is a significant tool in the clinical management of pregnancy and is increasingly used globally. The status of the pregnant woman and the fetus may vary regarding clinical management, views in the community and legislation. The overall aim of the study was to investigate experiences and views among health professionals in Vietnam on different aspects of the fetus, prioritisation and potential conflicts between maternal and fetal health interests.
Methods: A cross-sectional study design using a structured questionnaire. Eligible participants were obstetricians/gynecologists, midwives and sonographers. Public health facilities were purposively selected to obtain a representative sample in the Hanoi region, Vietnam. The final sample included 882 health professionals.
Results: Participating health professionals were obstetricians/gynecologists (n=289; 32.7%), midwives (n=535; 60.7%) and sonographers (n=58; 6.6%). The mean age was 34.8 years, and mean years in the profession were 10.3. 60.3% of participants agreed that “The fetus is a person from the time of conception”. 19.7% agreed, and 60.5% disagreed with the statement, “The fetus is never a patient, only the pregnant woman can be the patient”. A majority of the participants (54.4%) agreed that “Maternal health interests should always be prioritised over fetal health interests in care provided”, whereas 18.7% disagreed, and 27.1% were neutral. Participants who performed ultrasounds were more likely to agree that “Fetal health interests are being given more weight in decision-making, the further the gestation advances”, compared to those who did not perform ultrasounds (cOR 2.47, CI 1.27-4.79: n=811).
Conclusions: Our results indicate that a large proportion of health professionals in Vietnam assign the fetus the status of being a person, where personhood gradually evolves during pregnancy. To a large extent, the fetus was considered a patient with its own health interests, although a majority gave priority to maternal health interests. Health professionals appear to favour increased legal protection of the fetus. Strengthening the legal status of the fetus might have adverse implications for maternal autonomy however and would need careful monitoring if this were to occur. Maternal reproductive rights might need to be further safeguarded.
Sepsis and shock septic among patients with hematological malignancies: Factors associated with mortality
Authors: Silva Luciane Luz e , Ferreira Diogo Boldim , Goto Janaina Midori , Becker Otavio Monteiro , Tuma Paula , Medeiros Eduardo Alexandrino Servolo 
Published: March 2023

Abstract

Background: Sepsis is the leading cause of death in patients with onco-hematological diseases with mortality rate of up to 60%. Despite the high relevance of sepsis, few studies have analyzed its impact on this population. To evaluate the factors associated with 30- and 90-day mortality in onco-hematological patients and sepsis.
Methods: This retrospective cohort study was conducted at the Euryclides de Jesus Zerbini Transplant Hospital, a tertiary service for patients with hematological malignancies and bone marrow transplantation in São Paulo, Brazil. We included patients diagnosed with sepsis consecutively between August 2013 and July 2016 and followed-up for 30 and 90 days.
Results: Over the 3-year period, 123 patients with sepsis were diagnosed, median age of 59.7 years. The most frequent hematological disease was acute leukemia (31.0%). Sepsis and septic shock occurred in 52.2% and 47.8% of patients, respectively. The mortality rate was 33.9% at 30 days and 49.1% at 90 days. The main infectious diseases were pneumonia (32.7%) and bloodstream infections (30.1%). In multivariate analysis, the factors related to 30-day mortality were Sequential Organ Failure Assessment (SOFA) score (p=0.001), severe neutropenia (p=0.049), thrombocytopenia (p=0.045), and increased bilirubin (p=0.038). The associated factors to 90-day mortality were Sequential Organ Failure Assessment score (p=0.001), thrombocytopenia (p=0.45), and increased bilirubin (p=0.066). Infectious agents were identified in 46.9% of cases. Klebsiella pneumoniae was the predominant species and carbapenem-resistant in 61.5% of cases.
Conclusions: SOFA score, thrombocytopenia and increased bilirubin were factors associated with mortality in onco-hematological patients and sepsis.
Anti-nanodisc antibodies specifically capture nanodiscs and facilitate molecular interaction kinetics studies for membrane protein
Authors: Ogasawara Satoshi , Nakagawa Fuhito , Kikkawa Marin , Chen Sisi , Miyashita Yasuomi , Hamaguchi-Suzuki Norie , Shibuya Minami , Yamashita Soichi , Nagase Lisa , Yasuda Satoshi , Shiroishi Mitsunori , Senda Toshiya , Ito Keisuke , Murata Takeshi 
Published: March 2023

Abstract
Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid environment and better thermostability in a detergent-free buffer. This enables the determination of the thermodynamic and kinetic parameters of small molecule binding by surface plasmon resonance. In this study, we generated a nanodisc specific anti-MSP (membrane scaffold protein) monoclonal antibody biND5 for molecular interaction analysis of nanodiscs. The antibody, biND5 bound to various types of nanodiscs with sub-nanomolar to nanomolar affinity. Epitope mapping analysis revealed specific recognition of 8 amino acid residues in the exposed helix structure of MSP. Further, we performed kinetics binding analysis between adenosine A2a receptor reconstituted nanodiscs and small molecule antagonist ZM241385 using biND5 immobilized sensor chips. These results show that biND5 facilitates the molecular interaction kinetics analysis of membrane proteins substituted in nanodiscs.