bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction of reversible cysteine ligation ability to the biliverdin‐binding cyanobacteriochrome photoreceptor
Authors: Suzuki Takahisa , Yoshimura Masataka , Hoshino Hiroki , Fushimi Keiji , Arai Munehito , Narikawa Rei 
Published: July 2023

Cyanobacteriochrome (CBCR) photoreceptors are distantly related to the canonical red/far‐red reversible phytochrome photoreceptors. In the case of the CBCRs, only the GAF domain is required for chromophore incorporation and photoconversion. The GAF domains of CBCR are highly diversified into many lineages to sense various colors of light. These CBCR GAF domains are divided into two types: those possessing only the canonical Cys residue and those with both canonical and second Cys residues. The canonical Cys residue stably ligates to the chromophore in both cases. The second Cys residue mostly shows reversible adduct formation with the chromophore during photoconversion for spectral tuning. In this study, we focused on the CBCR GAF domain AnPixJg2_BV4, which possesses only the canonical Cys residue. AnPixJg2_BV4 covalently ligates to the biliverdin (BV) chromophore and shows far‐red/orange reversible photoconversion. Because BV is a mammalian intrinsic chromophore, BV‐binding molecules are advantageous for in vivo optogenetic and bioimaging tool development. To obtain a better developmental platform molecule, we performed site‐saturation random mutagenesis and serendipitously obtained a unique variant molecule that showed far‐red/blue reversible photoconversion, in which the Cys residue was introduced near the chromophore. This introduced Cys residue functioned as the second Cys residue that reversibly ligated with the chromophore. Because the position of the introduced Cys residue is distinct from the known second Cys residues, the variant molecule obtained in this study would expand our knowledge about the spectral tuning mechanism of CBCRs and contribute to tool development.
Mycorrhizae enhance reactive minerals but reduce mineral‐associated carbon
Authors: Li Huan , Yu Guang‐Hui , Hao Liping , Qiu Yunpeng , Hu Shuijin 
Published: July 2023

AbstractSoil organic carbon (C) is the largest active C pool of Earth's surface and is thus vital in sustaining terrestrial productivity and climate stability. Arbuscular mycorrhizal fungi (AMF) form symbioses with most terrestrial plants and critically modulate soil C dynamics. Yet, it remains unclear whether and how AMF–root associations (i.e., mycorrhizae) interact with soil minerals to affect soil C cycling. Here we showed that the presence of both roots and AMF increased soil dissolved organic C and reactive Fe minerals, as well as litter decomposition and soil CO2 emissions. However, it reduced mineral‐associated C. Also, high‐resolution nanoscale secondary ion mass spectrometry images showed the existence of a thin coating (0.5–1.0 μm thick) of 56Fe16O− (Fe minerals) on the surface of 12C14N− (fungal biomass), illustrating the close physical association between fungal hyphae and soil Fe minerals. In addition, AMF genera were divergently related to reactive Fe minerals, with Glomus being positively but Paraglomus and Acaulospora negatively correlated with reactive Fe minerals. Moreover, the presence of roots and AMF, particularly when combined with litter addition, enhanced the abundances of several critical soil bacterial genera that are associated with the formation of reactive minerals in soils. A conceptual framework was further proposed to illustrate how AMF–root associations impact soil C cycling in the rhizosphere. Briefly, root exudates and the inoculated AMF not only stimulated the decomposition of litter and SOC and promoted the production of CO2 emission, but also drove soil C persistence by unlocking mineral elements and promoting the formation of reactive minerals. Together, these findings provide new insights into the mechanisms that underlie the formation of reactive minerals and have significant implications for understanding and managing soil C persistence.
Small grassland fragments and connectivity support high arthropod functional diversity in highly modified landscapes
Authors: Korányi Dávid , Gallé Róbert , Torma Attila , Gallé‐Szpisjak Nikolett , Batáry Péter 
Published: July 2023

Abstract
Grassland ecosystems undergo dramatic habitat loss and fragmentation worldwide due to agricultural expansion and intensification. Among different taxonomic groups, grassland arthropods are particularly sensitive to this process and, therefore, are exposed to considerable risk.
Although many studies focus on land use impacts on arthropod diversity, these mostly consider taxonomic diversity and neglect trait‐mediated functional responses. However, studying functional diversity often provides more accurate insights into ecosystem processes.
Here, we assessed the effect of fragment size and connectivity on the functional composition (community‐weighted mean trait values) and diversity (Rao's quadratic entropy) of two diverse and abundant arthropod groups: spiders and true bugs. We assigned functional traits for more than 300 species collected from 30 sandy steppe (forest‐steppes) and 30 loess steppe fragments (kurgans) in the southern part of the Hungarian Great Plain.
Functional responses to fragmentation were observed for spiders in forest‐steppes and for true bugs in kurgans. We found higher functional diversity in better‐connected fragments for spiders and in small fragments for both groups. We collected small, humidity‐preferring and web‐building spiders in small fragments, and there were more ballooning spiders with moist habitat preferences in well‐connected fragments. Furthermore, increasing grassland connectivity resulted in a significantly higher proportion of polyphagous and humidity‐preferring individuals in the true bug communities.
Our results highlight the importance of small grassland fragments in maintaining high arthropod functional diversity. Even small fragments in a well‐connected grassland network can promote ecosystem functioning and associated services within human‐dominated landscapes.
Epidemiology of pressure ulcers in Le Mans General Hospital between 1996 and 2019: Impact of a dedicated “Pressure ulcer, Wounds and Healing” task force
Authors: Marchon Louis , Maillard Hervé 
Published: July 2023

AbstractPressure ulcers (PUs) are one of the most important care‐related ailments, making their prevention a pressing concern for hospital structures. Epidemiology of PU is interesting to adapt human resources and observe the impact of targeted public health measures. Very few data are presented in the French literature. In this context, a dedicated “Pressure ulcer, Wounds and Healing” task force was created in 1996 by a multidisciplinary team of physicians, administrative staff, and paramedics in the CH of Le Mans. Alongside this, an annual prevalence study was performed between 1996 and 2019 in CH of Le Mans, collecting relevant data: the number of patients who presented pressure ulcers, the number of patients who were at risk of developing pressure ulcers, and the severity of these ulcers. This study brings new data about PU epidemiology in France and shows a significant decrease in the prevalence, becoming lower than the national prevalence. Also, a significant time‐related regression of the prevalence was observed, the severity level continually decreased whereas the number of geriatric patients grew and patients with PU's risk remained constant. Finally, the number of patients who developed a PU within the hospitalization decreased too. We observed a link between the creation of the task force and the evolution of pressure ulcer epidemiology, thus recommending that the same practices be adopted in other hospitals and fields of application.
COVID‐19 and primary wound healing: A new insights and advance
Authors: Li Danyi , Cao Wenjie , Zhou Qun , Wu Xiaomin , Song Xiayun , Qin Haofang 
Published: July 2023

AbstractWith the outbreak and pandemic of coronavirus disease‐2019 (COVID‐19), a huge number of people died of it. Apart from lung injuries, multiple organs have been confirmed to be impaired. In COVID‐19 time, primary wound healing processes always prolong, however, its possible underlying mechanisms are still unclear. Therefore, to overcome this clinical problem, clarifying its underlying mechanisms clearly is necessary and urgently needed. In this review, we summarized that COVID‐19 can prolong primary wound healing by inducing excessive inflammation and oxidative stress, disturbing immune system and haematological system, as well as influencing the functions and viability of epidermal stem cells (ESCs). Otherwise, we summarized that the strict control measures of blocking up COVID‐19 pandemic can also have side effects on primary wound healing process.
Phase transition monitoring and temperature sensing via FIR technology in Bi/Sm‐codoped KNN transparent ceramics
Authors: Zhou Ping , Yu Fangyuan , Zeng Xiangfu , Gao Min , Zhao Chunlin , Lin Cong , Lin Tengfei , Luo Laihui , Lin Jinfeng , Wu Xiao 
Published: July 2023

AbstractThe phase transition temperature (e.g., that of orthorhombic‐tetragonal TO‐T) of relaxor ferroelectrics are commonly obtained through electrical method (i.e., temperature dependence of dielectric constant), and the samples need to be coated with metal electrode and tested by a sophisticated impedance analyzer. This contact measuring method is inefficient, inconvenient and easy to damage the sample surface, inapplicable to transparent ferroelectrics. Here, we successfully fabricated Bi/Sm co‐doped K0.5Na0.5NbO3 transparent ceramics with photoluminescent behavior and relaxor‐like ferroelectricity, which simultaneously realized TO‐T monitoring and temperature sensing via fluorescence intensity ratio (FIR) technology. This simple, rapid, noncontact and nondestructive optical way displays small TO‐T deviation (merely 0.78%) compared to the electrical method. And the temperature‐dependent optical characteristics and coercive electric field all present abrupt changes, whose abnormal temperature regions are in accordance with that around TO‐T. In addition, the maximum absolute sensitivity and relative sensitivity of the ceramics reach 0.0072 K−1 (at 533 K) and 0.0111 K−1 (at 453 K), respectively, exhibiting superior optical temperature sensing performance. The tactical use of FIR technology is of great significance for widening the applications of luminescent‐ferroelectric transparent ceramics.
Mg and Al mixed effects on thermal properties in aluminosilicate glasses
Authors: Ke Xuefei , Wang Xiaowei , Wang Yadan , Ren Xiaoming , Tao Haizheng 
Published: July 2023

AbstractBy using the aerodynamic levitation and laser melting technique to well extend the glass‐forming region into the Mg‐rich and peraluminous regime, a series of magnesium aluminosilicate glasses were prepared to investigate the Mg and Al mixed effects on thermal properties, including glass transition temperature (Tg), crystallization behavior, and thermal stability. With the gradual substitution of Mg by Al, Tg exhibits two types of near‐linear rises with different slopes in two compositional regions separated by r = 0.57, where r is equal to the molar ratio of [Al2O3]/([Al2O3] + [MgO]). Moreover, when it comes to other properties, that is, crystallization behavior and thermal stability, this critical point precisely appears at the same r = 0.57. Compared to the slower increase of Tg in Mg‐rich region, the steeper rise of Tg in the peraluminous region is mainly ascribed to the step‐by‐step formation of oxygen triclusters driven by Pauling's second rule. Moreover, the occurrence of the critical point for Tg rise at r = 0.57 rather than the theoretical 0.5 can be seen as a proof of the role of Mg cations partly as a network former.
Online Hate: Is Hate an Infectious Disease? Is Social Media a Promoter?
Authors: Popa‐Wyatt Mihaela 
Published: July 2023

ABSTRACTOur time is marked by a resurgence of hate that threatens to increase oppression. Social media has contributed to this by acting as a medium through which hate speech is spread. How should we model the spread of hate? This article considers two models. First, I consider a simple contagion model. In this model, hate spreads like a virus through a social network. This model, however, fails to capture the fact that people do not acquire hatred from a single infectious contact. Instead, it builds up in a person's beliefs and attitudes through time until the infection reaches a level where the subject themselves becomes a generator of hate speech. Second, to accommodate this, I consider an alternative model known ascomplex contagion. I argue that not only is a complex contagion model more explanatory and predictive, but it can be used to explain why certain features of social media cause it to be a promoter of hate. I conclude by sketching some mitigation strategies.
Technology first: The impact on technology availability for people with intellectual and developmental disabilities
Authors: Friedman Carli 
Published: July 2023

AbstractBackgroundIn the United States, 16 states have adopted Technology First initiatives to improve people with intellectual and developmental disabilities' access to technology.MethodOur aim was to examine if Technology First initiatives impact the allocation of technology in Home and Community‐Based Services (HCBS) for people with intellectual and developmental disabilities. To do so, we analysed HCBS programs from across the United States in fiscal year 2021.ResultsTechnology First states were more likely to offer telehealth service delivery in their HCBS programs. However, we found few other significant differences in allocation of technology – the number of people receiving and projected spending – based on states' Technology First status.ConclusionsWhile these findings do not mean that there is no value in Technology First initiatives, it appears these initiatives have yet to truly impact resource allocation when it comes to HCBS.
SNORA73B promotes endometrial cancer progression through targeting MIB1 and regulating host gene RCC1 alternative splicing
Authors: Chen Xi , Li Qian‐hui , Xie Bu‐min , Ji Yu‐meng , Han Yang , Zhao Yang 
Published: July 2023

AbstractEndometrial cancer (EC) is a common gynaecological malignant tumour with unclear pathogenesis. Small nucleolar RNA (snoRNA) is involved in many biological processes, including those of cancers. Using the Cancer Genome Atlas (TCGA) database, the expression pattern of a snoRNA, SNORA73B, was analysed. The biological functions of SNORA73B were assessed by in vitro proliferation, apoptosis, migration, and invasion assays and in vivo by the xenograft model. RNA sequencing (RNA‐seq) and RNA immunoprecipitation assays were performed to determine the relationship between SNORA73B and its target genes. High‐performance liquid chromatography (HPLC) was performed to detect the pseudouridine content of the mindbomb E3 ubiquitin protein ligase 1 gene (MIB1). The stability of MIB1 mRNA was evaluated using a transcription inhibitor, actinomycin D. By performing co‐immunoprecipitation assays, the change in the ubiquitin levels of the Jagged canonical Notch ligand 1 (Jag 1), caused by SNORA73B and MIB1, was identified. RNA‐seq and qRT‐PCR were performed to detect the alternative splicing of the regulator of the chromosome condensation 1 gene (RCC1). The TCGA database analysis showed that SNORA73B was highly expressed in EC. SNORA73B promoted cell proliferation, migration, and invasion and inhibited apoptosis. SNORA73B modified the pseudouridine content in MIB1 and increased the stability of MIB1 mRNA and protein; thus, it affected Jag 1 ubiquitination and further activated the Notch pathway. SNORA73B also affected the alternative splicing of RCC1, increasing the number of transcripts, RCC1‐T2 and RCC1‐T3, which promoted cell proliferation, migration, and invasion. SNORA73B can be a potential target for EC.
An improved anisotropic continuum model for the flow and heat transfer in grain aeration system
Authors: Liu Wenlei , Chen Guixiang , Zheng Deqian , Ge Mengmeng , Liu Chaosai 
Published: July 2023

AbstractTo investigate the influence of pore structure distribution on the flow and heat transfer during the aeration process of a grain pile, an anisotropic continuous model (ACM) was developed based on the homogeneous continuous model (HCM). The improved ACM includes spatial resistance factors and effective thermal conductivity correction coefficients. The experimental results were compared with the particle‐resolved computational fluid dynamics (PRCFD) and ACM simulation results to verify the accuracy. At higher inlet velocities, the HCM underestimated the pressure drop in the wheat fixed bed, with an average deviation of 21%. In contrast, the improved ACM incorporates the effect of resistance factors and had an average deviation of less than 10% from the experimental. By simulating the pilot‐scale bin aeration system, the accuracy of the improved ACM applied to the real bin was ensured, considering the change in the porosity of the grain pile along the center of the bin to the bin wall and the grain pile height direction. The range of variable porosity distribution was set at .35–.45, and the total average deviation between the ACM simulation static pressure and the experimental value was 9.7% when the inlet airflow velocity was .019 m/s. The simulated temperature of the ACM matches the measured temperature better compared to the temperature values of the grain pile at different heights in the HCM with a constant porosity of .45. Therefore, the impact of four central air collection duct forms on airflow and temperature was discussed, and it was determined that the pipe with a larger diameter at the top and a smaller diameter at the bottom air collection duct was more advantageous when used in a horizontal aeration system by applying the improved ACM to different scenarios.Practical ApplicationsThis study introduces the resistance factor and effective thermal conductivity in a laboratory‐scale fixed bed of wheat. An improved anisotropic continuous model was established for simulating the flow and heat transfer in the fixed bed during the aeration process. The improved anisotropic continuous model accurately reflected the non‐uniformity of fixed bed flow and temperature transfer in the fixed bed. This model can be employed for simulating flow and heat transfer in large‐scale actual storage systems characterized by heterogeneous pore distribution, while ensuring appropriate computational efficiency and precision.
Impaired facial emotion recognition in relation to social behaviours in de novo Parkinson's disease
Authors: Slomp Anne Carien , van der Zee Sygrid , Boertien Jeffrey M. , Gerritsen Marleen J. J. , van Laar Teus , Spikman Jacoba M. 
Published: July 2023

AbstractFacial emotion recognition (FER) is a crucial component of social cognition and is essential in social‐interpersonal behaviour regulation. Although FER impairment is well‐established in advanced PD, data about FER at the time of diagnosis and its relationship with social behavioural problems in daily life are lacking. The aim was to examine FER at the time of PD diagnosis compared to a matched healthy control (HC) group and to associate FER with indices of social behavioural problems. In total, 142 de novo, treatment‐naïve PD patients and 142 HC were included. FER was assessed by the Ekman 60 faces test (EFT). Behavioural problems in PD patients were assessed using the Dysexecutive Questionnaire (DEX‐self and DEX‐proxy) and the Apathy Evaluation Scale (AES‐self). PD patients had significantly lower EFT‐total scores (p = .001) compared to HC, with worse recognition of Disgust (p = .001) and Sadness (p = .016). Correlational analyses yielded significant correlations between AES‐self and both EFT‐total (rs = .28) and Fear (rs = .22). Significant negative correlations were found between DEX‐proxy and both EFT‐total (rs = −.28) and Anger (rs = −.26). Analyses of DEX‐subscales showed that proxy ratings were significantly higher than patient‐ratings for the Social Conventions subscale (p = .047). This DEX‐proxy subscale had the strongest correlation with EFT‐total (rs = −.29). Results show that de novo PD patients already show impaired FER compared to HC. In addition, lower FER is linked to self‐reported apathy and proxy‐reported social‐behavioural problems, especially concerning social conventions. These findings validate the importance of the inclusion of social cognition measures in the neuropsychological assessment even in early PD.
Period Power: Organizational Stigma, Multimodality, and Social Entrepreneurship in the Menstrual Products Industry
Authors: Werner Mirjam D. , Punzi Maria Carmen , Turkenburg A. J. K. 
Published: July 2023

AbstractIn this article, we contribute to the recent direction in the organizational stigma literature that focuses on stigma as providing opportunities for organizations. Drawing on a qualitative abductive study of 90 social enterprises in the menstrual products industry, we extend the literature by showing how the organizational form of social enterprises allows them to put the societal issue of menstruation stigma at the core of their ventures. Specifically, we find that these social enterprises take a disruptive strategy, and we elaborate on the tactics of normalization and moralization on which they draw by highlighting the essential role of multimodality in the process of destigmatizing menstruation. In light of the tabooed nature of menstruation, this multimodal approach is key to challenging existing hidden, taken‐for‐granted norms around menstruation and supplanting them with alternative ones. Our study has important implications for the literatures on organizational stigma, social enterprises, and multimodality and points to their strong conceptual complementarity for understanding processes of societal change.
Gender Differences in Help‐Seeking: A Meta‐analysis of Japanese Studies, Including Unreported Data1
Authors: Nagai Satoru , Kimura Masato , Honda Masahiro , Iida Toshiharu , Mizuno Haruhisa 
Published: July 2023

AbstractThis meta‐analysis integrated and analyzed previous Japanese findings on gender differences in help‐seeking intentions and attitudes. We searched relevant studies using the Citation Information by the National Institute of Informatics database and identified 85 articles. We also analyzed unreported statistical information provided by the primary authors of these studies. The results indicated that women had a higher tendency of intentions to seek help than men (d = −0.143, 95% CI [−0.196, −0.091], k = 64, n = 29,256). Further analysis of the types of help‐seeking showed that women intended to seek help only from friends and family members. In contrast, university students intended to seek help from psychological professionals, physicians, and other formal sources for depressive symptoms, and this intention was higher among male students. Moreover, women had more favorable attitudes about seeking help than men (d = −0.092, 95% CI [−0.156, −0.027], k = 30, n = 11,536). Furthermore, several analyses indicated heterogeneity. However, we could not identify specific potential moderators. We also found that gender differences were smaller in studies that assessed help‐seeking intentions using unvalidated measures.