bluuebunny/crossref_metadata_2025_split huggingface dataset:
International experience of using report forms for hospital-based health technology asssessment
Authors: Філінюк О. М. , Бабенко М. М. 
Published: March 2023

Hospital-based health technology assessment (HB-HTA) is one of the components of public management and support hospital managers to science-based decision-making regarding the implementation of new and innovative health technologies (HT). HB-HTA includes the processes and methods used to make HTA reports in and for hospitals. Ukraine has already started implementing hospital-based HTA, but a number of steps are still needed to fully implement HTA at the hospitals. One of them is the choice of HB-HTA report form, which will be appropriate to use in the practical activities of hospitals in Ukraine.
The purpose of the study is to analyse the international experience of using different HB-HTA report form with the aim of selecting the optimal HB-HTA report form for hospitals in Ukraine. There were analysed different forms of HTA reports in Ukraine regulatory framework, international scientific literature, the AdHopHTA handbook, which included the following countries: Norway, Finland, Turkey, Spain, Austria, Italy, Estonia, Denmark, Switzerland, in international HTA database INAHTA, Canadian and Kazakhstan report databases. The methods of content analysis, systematization and generalization were used.
Making managerial decisions about investment or disinvestment in health technology requires information that meets the hospital stakeholders needs. Such scientifically based information is provided by HB-HTA report form.
There are a wide range of HB-HTA reports forms in terms of content, subject matter, structure and resources (time and staff). Each is based on the EUnetHTA HTA core model. For introducing a hospital-based HTA, the countries of the world most often choose the mini-HTA form. Mini-HTA supports hospital managers to make science-based strategic decisions of the introduction of new treatment methods, new indications for the use of existing technology, medical equipment, medical devices, or stopping the usage of health technology. The choice between performing a mini-HTA or a more comprehensive hospital-based HTA often requires a balance between the quality and thoroughness and the necessary speed of assessment in a specific situation.
From the authors' point of view, the most applicable to Ukrainian context is the mini-HTA form. Adapting mini-HTA and approving it as a recommended report form at the state level will provide an opportunity to more widely HTA usage by hospitals in Ukraine.
Attributes of pharmacy's educational activities according to good pharmacy practice standards from the perspective of patients with diabetes
Authors: Власенко І. О. , Давтян Л. Л. 
Published: March 2023

According to the Good Pharmaceutical Practice (GPP) Standards of Quality of Pharmacy Services, pharmacists should participate in preventive measures to improve the health of the population and prevent disease. The problem of diabetes is becoming increasingly relevant due to its prevalence and a significant number of undiagnosed cases. Patients with diabetes are frequent visitors to pharmacies and have specific needs for treatment.
The purpose of the study was to determine the attributes of pharmaceutical educational activities in pharmacies according to the standards of GPP from the perspective of patients with diabetes, as well as to compare the obtained results with similar ones in other countries.
The objects of the study were information sources regarding the involvement of pharmacists in the strategy of preventing diabetes in other countries, using literature review and analytical methods. To study the perspective of patients with diabetes, a semi-structured in-depth interview of patients with diabetes who use insulin therapy was applied.
Based on research using the semi-structured in-depth interview method, attributes of educational activities were identified in providing pharmaceutical care to patients with diabetes according to GPP standards: identifying individuals with risk factor of diabetes and people with undiagnosed diabetes; group training of diabetes patients in self-management control; and recommendations flu vaccination in the pre-epidemic period. The availability of diabetes risk factor detection and blood glucose testing in pharmacies contributes to early diagnosis and motivates patients to change their lifestyles. Training people with diabetes by qualified specialists are important for diabetes patients. The organasing of the «diabetes self management school» in pharmacies will increase the accessibility of training for diabetes patients and at the same time enhance the role of pharmacists in clinical practice and the social image of the pharmacy. To promote flu vaccination among patients with diabetes, pharmacists should be actively involved in providing information and promoting vaccination.
The identified attributes of educational activities in providing pharmaceutical care according to GPP standards have already been implemented in many countries of the world and have demonstrated their high efficiency for the health care system.
The Influence of Time Budget Pressure, Time Deadline Pressure and Work Stress on Audit Quality of External Auditor
Authors: Iksan Dodik Juliardi 
Published: March 2023

The purpose of this study was to try the goods of time pressure, deadline pressure, and work pressure on test quality among PAF observers in Malang City. The logical model exercised is a multitudinous retrogression dissection where the dependent variables are time pressure( X1), deadline pressure( X2), job pressure( X3) and the independent variable is test quality( Y). The study population was his PAF accountants in Malang, totaling 86. The sample exercised comported of her 52 repliers, utilizing a accessible sample of his eight account enterprises( PAF) in Malang megacity. A Likert scale( 1- 4) questionnaire is exercised for the dimension. Data source is primary. This study shows that time pressure, deadline pressure, and job pressure don't affect the quality of foreign checkups. terminations of this study are that the questionnaire effects don't give his 100 valid comebacks due to lack of management, that the repliers are pacified by youthful observers, and that the study effects are in this range. Secondly, it can not be generalized to multitudinous regions in Indonesia. Research will be limited to a defined bone in Malang City.
EFEKTIVITAS PENGELOLAAN BADAN USAHA MILIK DESA DALAM PEMBERDAYAAN MASYARAKAT DI DESA SIGERONGAN
Authors: Darusman Erwin , Suharyani Suharyani 
Published: March 2023

The problem raised in this study is how the effectiveness of the management of Village-Owned Enterprises in community empowerment in Sigerongan Village. This study aims to determine the level of effectiveness of the management of Village-Owned Enterprises in community empowerment in Sigerongan Village. This study uses an evaluative method with the CIPP model (context, input, process, product). This study does not use a sample because the population is less than one hundred, while the number of subjects is 20 people and the data collection techniques used are questionnaires, observation, documentation. The analytical method used is a Likert scale percentage technique analysis with the respondent's answer score formula for the ideal score times 100%. The results of the analysis of the Likert scale percentage technique show that the context component is in the very effective category, namely 88.5%, the input component is in the very effective category, namely 81.5%, the process component is in the very effective category, which is 80.4% and the last component is the the product is in the effective category, which is 79.25%. While the overall results are in the very effective category, namely 82.8%, which means that it has been running very effectively. So it can be concluded that the effectiveness of the management of Village Owned Enterprises in community empowerment in Sigerongan Village has been running effectively with the objectives to be achievedKey Words: Effectiveness, Management, Village Owned EnterprisesMasalah yang diangkat dalam penelitian ini adalah bagaimana efektivitas pengelolaan Badan Usaha Milik Desa dalam pemberdayaan masyarakat di Desa Sigerongan. Penelitian ini bertujuan untuk mengetahui tingkat efektivitas pengelolaan Badan Usaha Milik Desa dalam pemberdayaan masyarakat di Desa Sigerongan. Penelitian ini menggunakan metode evaluative dengan model CIPP (context, input, process, product). Penelitian ini tidak menggunakan sampel karena jumlah populasinya kurang dari seratus, adapun jumlah subjek berjumlah 20 orang dan teknik pengumpulan data yang digunakan yaitu angket, observasi, dokumentasi. Metode analisis yang digunakan adalah analisis teknik persentase skala likert dengan rumus skor jawaban responden bagi skor ideal kali 100%. Hasil dari analisis teknik persentase skala likert ini menunjukan bahwa komponen context masuk kategori sangat efektif yakni 88,5%, komponen input masuk kategori sangat efektif yakni 81,5%, komponen process masuk kategori sangat efektif yakni 80,4% dan yang trakhir adalah komponen product masuk kategori efektif yakni 79,25%. Sedangkan hasil keseluruhan berada pada kategori sangat efektif yakni 82,8%, yang brarti sudah berjalan secara sangat efektif. Jadi dapat disimpulkan bahwa efektivitas pengelolaan Badan Usaha Milik Desa dalam pemberdayaan masyarakat di Desa Sigerongan sudah berjalan secara efektif sehingga yang direncanakan bias tercapaKata Kunci: Efktivitas, Pengelolaan, Badan Usaha Milik Desa
IMPLEMENTASI ADMINISTRASI SEKOLAH DASAR NEGERI 30 AMPENAN
Authors: Anam M. Chairul , Muzanni Ahmad , Hadi Samsul 
Published: March 2023

The purpose of this research is to describe the management of the primary school 30 Ampenan. This research is a qualitative descriptive study, the results of which show that, first, the implementation of student management has been effective: all student management requirements are complete and well organized, can run effectively even though there is no administrative staff. Fourth, the application of financial administration is related to financial standards , which includes: Investment costs, management costs and personnel costs Fifth, there are problems in the implementation of management, which have an impact on administrative inefficiencies.Keywords: implementastion, elementary school, administration.Abstrak: Tujuan dari penelitian ini adalah untuk mendeskripsikan pengelolaan SDN 30 Ampenan. Penelitian ini merupakan penelitian deskriptif kualitatif, yang hasilnya menunjukkan bahwa, pertama, pelaksanaan manajemen kemahasiswaan sudah efektif: semua persyaratan manajemen kesiswaan lengkap dan tertata dengan baik, dapat berjalan dengan efektif meskipun tidak ada staf Tata Usaha.Keempat, penerapan administrasi keuangan terkait dengan standar keuangan, yang meliputi: Biaya investasi, biaya manajemen dan biaya personel Kelima, terdapat masalah dalam pelaksanaan manajemen, yang berdampak pada inefisiensi adminstrasi.Kata Kunci: implementasi, sekolah dasar, administrasi
Meningkatkan Hasil Belajar IPA dalam Memahami Rangkaian Listrik Seri Melalui Penerapan Metode Eksperimen Pada Siswa Kelas VI SDN 1 Mantang
Authors: Irfan Ahmad Zainul , Najamuddin M. 
Published: March 2023

Abstract : This study aims to improve science learning outcomes in understanding series electrical circuits through the application of experimental methods in grade VI students of SDN 1 Mantang in the odd semester of the 2022/2023 academic year. The method used in this research is the experimental method in class VI students of SDN 1 Mantang. The experimental method is one of the teaching methods that in its presentation is appropriate / suitable to be applied in learning Natural Sciences, because with this method students can develop optimal thinking skills. This class action research was conducted in two cycles on 32 students consisting of 11 male students and 21 female students. After the research was conducted, students' understanding and learning outcomes of science lessons on series electrical circuits material increased by using experimental methods with an average score of 66 in cycle I to 86.5 in cycle II. In the efforts made by researchers in improving science learning outcomes, it can be concluded that the experimental method is very helpful for teachers in carrying out the learning process, especially when demonstrating with media or materials as a medium for student learning.Keywords: Improvement, Science Learning Outcomes, Experimental MethodAbstrak : Penelitian ini bertujuan untuk meningkatkan hasil belajar IPA dalam memahami rangkaian listrik seri melalui penerapan metode eksperimen pada siswa kelas VI SDN 1 Mantang semester ganjil tahun pelajaran 2022/2023. Metode yang digunakan dalam penelitian ini adalah metode eksperimen pada siswa kelas VI SDN 1 Mantang. Metode eksperimen adalah merupakan salah satu metode mengajar yang dalam penyajiannya sesuai/cocok untuk diterapkan dalam pembelajaran Ilmu Pengetahuan Alam, karena dengan metode ini siswa dapat mengembangkan kemampuan berfikir secara optimal. Penelitian tindakan kelas ini dilakukan sebanyak dua siklus terhadap 32 orang siswa yang terdiri dari 11 siswa laki-laki dan 21 siswa perempuan. Setelah penelitian dilakukan, pemahaman dan hasil belajar siswa terhadap pelajaran IPA materi rangkaian listrik seri menjadi meningkat dengan menggunakan metode eksperimen dengan nilai rata-rata dari 66 pada siklus I menjadi 86,5 pada siklus II. Dalam usaha yang dilakukan peneliti dalam meningkatkan hasil belajar IPA dapat disimpulkan bahwa dengan metode eksperimen sangat membantu guru dalam melakukan proses pembelajaran terutama saat melakukan peragaan dengan media atau bahan sebagai media belajar siswa. Kata konci: Peningkatan, Hasil Belajar IPA, Metode Eksperimen
Exploring the Parental Experiences in the Media: A Qualitative Analysis of Articles Written by Parents of Children with Autism in Bosnia and Herzegovina
Authors: Celebic Elvira , Memisevic Haris 
Published: March 2023

Aim: This paper presents a qualitative study of the experiences of parents raising children with autism, as reflected in the media. The study aimed to explore the lived experiences of parents of children with autism and the challenges they face in Bosnia and Herzegovina.
Methods: A content analysis of 20 media articles featuring parents of autistic children was conducted. The articles were selected from a range of sources, including newspapers, magazines, and online news portals.
Results: We identified four major themes: supports, education, spousal relationships, and future. It should be noted that these themes are often intertwined.
Conclusion: The findings highlight the importance of providing support and resources to parents of children with autism, as well as the need for greater awareness and understanding of the challenges they face. The implications of these findings for policy and practice are discussed, and suggestions for future research are presented.
Sex differences in cocaine self-administration by Wistar rats after predator odor exposure
Authors: Templeton-Jager Taylor J. , Diarra Siga , Gilpin Nicholas W. 
Published: March 2023

Traumatic stress disorders are defined in part by persistent avoidance of trauma-related contexts. Our lab uses a preclinical model of traumatic stress using predator odor (i.e., bobcat urine) in which some but not all rats exhibit persistent avoidance of odor-paired stimuli, similar to what is seen in humans. Bobcat urine exposure increases alcohol consumption in male Avoider rats, but it has not been tested for its effects on intake of other drugs. Here, we tested the effect of bobcat urine exposure on cocaine self-administration in adult male and female Wistar rats. We did not observe any effect of bobcat urine exposure on cocaine self-administration in male or female rats. We observed that (1) female rats with long access (6 h) to cocaine self-administer more cocaine than long-access males, (2) long-access males and females exhibit escalation of cocaine intake over time, (3) stressed rats gain less weight than unstressed rats following acute predator odor exposure, (4) baseline cocaine self-administration is predictive of subsequent cocaine self-administration. The results of this study may inform future work on predator odor effects on cocaine self-administration.
Selenium speciation-dependent cancer radiosensitization by induction of G2/M cell cycle arrest and apoptosis
Authors: Nie Shiqing , He Xin , Sun Zhiting , Zhang Yan , Liu Ting , Chen Tianfeng , Zhao Jianfu 
Published: March 2023

Introduction: Radiation therapy has Q6long been a routine and effective treatment for non-small cell lung cancer (NSCLC), but the radioresistance and side effects have limited its application. In recent years, the superiority showed by trace element selenium in tumor radiotherapy sensitization has received wide attention. However, different forms of selenium compounds exhibit different chemical properties and their mechanisms of action on tumors may be different.Methods: Human non-small cell lung cancer SPC-A1 cells were studied. Drug toxicity was detected by MTT assay. The selenium content absorbed in vitro at different time points was detected by ICP-MS. Colony formation were conducted to observe the radiosensitization effect of different selenium compounds on SPC-A1 cells, and to compare the proliferation ability of SPC-A1 cells treated by radiation alone and radiation combined with different selenium compounds. Cell migration was detected by cell scratch assay. The changes of cell cycle and apoptosis were detected by flow cytometry. DCFH-DA fluorescent probe was used to detect the effects of different selenium compounds combined with X-ray on ROS production.Results: In this study, these four representative selenium compounds all have a certain ability to enhance the ability of radiotherapy to inhibit tumor cell proliferation and migration, and the mechanism may be related to blocking cell cycle in G2/M phase, activating the caspase cascade and reducing intracellular ROS levels to induce tumor cell apoptosis. Among them, -2-valent organic selenium has the most obvious effect, mainly inhibits cell migration, and induces early apoptosis by activating a large number of caspase-3, and arrest the cell cycle in S phase and G2/M phase. 0-valent selenium nanoparticles mainly arrest the cell cycle in G2/M phase. +4-valent inorganic selenium exerts its antitumor effects primarily by inhibiting tumor cell migration and inducing early apoptosis of tumor cells.Discussion: In this paper, the antitumor effects of four different forms of selenium compounds combined with X-rays on SPC-A1 cells were investigated, and their inhibitory effects on the proliferation and migration of cancer cells and their mechanisms were examined. We found that the radiosensitizing effect of selenium on NSCLC was closely related to its selenium form through the study of the sensitizing effect of different kinds of selenium compounds on radiotherapy.
Comparison of current treatment strategy for osteonecrosis of the femoral head from the perspective of cell therapy
Authors: Wang Jiaqian , Xu Peirong , Zhou Liang 
Published: March 2023

Aims: The purpose of our study is to compare the effects of core decompression (CD) and bone grafting (BG) on osteonecrosis of the femoral head (ONFH). And evaluate the efficacy of CD based on cell therapy to provide guidance for the dose and number of cells.Methods: We searched PubMed, Embase, and the Cochrane Library between 2012 and 2022, with keywords including “osteonecrosis of the femoral head”, “core decompression” and “bone grafting”. We selected comparative studies of CD and BG, and the comparison of CD combined with bone marrow (BM) transplantation and CD alone. Changes in hip pain were assessed by VAS, hip function were assessed by HHS and WOMAC, and THA conversion rate was used as an evaluation tool for femoral head collapse. From these three aspects, the dose of bone marrow and the number of cells transplantation were subgroup analyzed.Results: Eleven studies were used to compare the efficacy of CD and BG. There was no significant difference in HHS, and the THA conversion rate of BG was significantly lower than that of CD. Thirteen CD studies based on cell therapy were included in the meta-analysis. Bone marrow aspiration concentrate (BMAC) can significantly improve VAS (mean difference (MD), 10.15; 95% confidence intervals (CI) 7.35 to 12.96, p &lt; 0.00001) and reduce THA conversion rate (odds ratio (OR), 2.38; 95% CI 1.26 to 4.47, p = 0.007). Medium dose bone marrow fluid has a lower p-value in THA conversion rate. The p values of bone marrow mononuclear cells (BMMC) of 109 magnitude in VAS score were lower.Conclusion: In general, there is no consensus on the use of BG in the treatment of ONFH. The enhancement of cell-based CD procedure shows promising results. Using 20 mL BMAC and 109 magnitude BMMC is likely to achieve better results.
The incremental significance of heart rate recovery as a predictor during exercise-stress myocardial perfusion SPECT imaging in individuals with suspected coronary artery disease
Authors: Yang Shuai , Xi Rui , Li Bing-Bing , Wang Xin-Chao , Song Li-Wei , Ji Tian-Xiong , Ma Hui-Zhu , Lu Hai-Li , Zhang Jing-Ying , Li Si-Jin , Wu Zhi-Fang 
Published: March 2023

BackgroundMajor adverse cardiac events (MACE) are more likely to occur when abnormal heart rate recovery (HRR). This study aimed to assess the incremental predictive significance of HRR over exercise stress myocardial perfusion single-photon emission computed tomography (MPS) results for MACE in individuals with suspected coronary artery disease (CAD).MethodsBetween January 2014 and December 2017, we continually gathered data on 595 patients with suspected CAD who received cycling exercise stress MPS. HRR at 1, 2, 3, and 4 min were used as study variables to obtain the optimal cut-off values of HRR for MACE. The difference between the peak heart rate achieved during exercise and the heart rate at 1, 2, 3, and 4 min was used to calculate the HRR, as shown in HRR3. Heart rate variations between two locations in time, such as HRR2 min−1 min, were used to establish the slope of HRR. All patients were followed for a minimum of 4 years, with MACE as the follow-up goal. The associations between HRR and MACE were assessed using Cox proportional hazards analyses.ResultsPatients with MACE were older (P = 0.001), and they also had higher rates of hypertension, dyslipidemia, diabetes, abnormal MPS findings (SSS ≥ 5%), medication history (all P &lt; 0.001), and lower HRR values (all P &lt; 0.01). Patients with and without MACE did not significantly vary in their HRR4 min−3 min. The optimal cut-off of HRR1, 2, and 3 combined with SSS can stratify the risk of MACE in people with suspected CAD (all P &lt; 0.001). HRR 1, 2, and 3 and its slope were linked to MACE in multivariate analysis, where HRR3 was the most significant risk predictor. With a global X2 increase from 101 to 126 (P &lt; 0.0001), HRR3 demonstrated the greatest improvement in the model's predictive capacity, incorporating clinical data and MPS outcomes.ConclusionsHRR at 3 min has a more excellent incremental prognostic value for predicting MACE in patients with suspected CAD following cycling exercise stress MPS. Therefore, incorporating HRR at 3 min into known predictive models may further improve the risk stratification of the patients.