bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiscale analysis on the mechanical behavior and failure mechanism of high strength concrete
Authors: Mei Qiquan , Wu Zhangyu , Yu Hongfa , Zhang Jinhua , Ma Haiyan 
Published: February 2023

AbstractHigh strength concrete (HSC) with superior strength advantage has been gaining widespread attention and engineering endorsement in recent years. For a better understanding of the mechanical responses and failure mechanisms of HSC, a novel three‐dimensional (3D) mesoscale model considering the meso‐structural features of concrete was proposed in this paper. First, a series of uniaxial compressive tests were conducted to investigate the compressive properties of HSC specimens with a strength of 80–90 MPa. After that, a 3D three‐phase mesoscale model consisting of mortar, coarse aggregate, and the interfacial transitional zone (ITZ) between them, was developed to perform the mesoscopic simulations of HSC. Then, systematic analysis and discussions on the compressive properties of HSC were presented in terms of the stress–strain curves, compressive strengths/toughness, failure patterns, cracking process, etc. Results indicate that HSC exhibited obvious brittle failure characteristics, and its strength was significantly related to the water‐to‐cement ratio and mineral admixture. At meso‐level, the cracking behaviors of mortar and ITZ phases were well modeled using the developed mesoscale model. Additionally, it was found that the cracking behavior of HSC was significantly associated with the ITZ characteristics. The developed mesoscale modeling approach has been proven to simulate and investigate concrete's compressive properties in a reliable manner, and can be applied further to the property analysis of concrete materials and structures.
Image‐guided diagnosis and treatment of glioblastoma
Authors: Bian Yongning , Wang Yaling , Chen Xueqian , Zhang Yong , Xiong Shaoqing , Su Dongdong 
Published: February 2023

AbstractGlioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM. In traditional surgical treatment, it is difficult to completely distinguish the boundary between tumor and surrounding normal tissue, resulting in incomplete resection of tumor. Therefore, the diagnosis and treatment of GBM are very challenging. Several molecular probes and nanoprobes have been reported to successfully penetrate the BBB, selectively target and accumulate in GBM to achieve in situ imaging of brain tumors, thus achieving accurate diagnosis and treatment of orthotopic or non‐orthotopic GBM. This paper reviews the advances of molecular probes and nanoprobes in image‐guided diagnosis and treatment of GBM. The design principle, application, and advantages of each probe are enumerated in detail. Finally, the prospects and potential challenges of probes in the diagnosis and treatment of GBM are discussed with a view to further promote the study and application of novel imaging probes in GBM.
Linac-based stereotactic salvage reirradiation for intraprostatic prostate cancer recurrence: toxicity and outcomes
Authors: Cozzi Salvatore , Finocchi Ghersi Sebastiano , Bardoscia Lilia , Najafi Masoumeh , Blandino Gladys , Alì Emanuele , Augugliaro Matteo , Vigo Federica , Ruggieri Maria Paola , Cardano Raffaele , Giaccherini Lucia , Iori Federico , Botti Andrea , Trojani Valeria , Ciammella Patrizia , Iotti Cinzia 
Published: February 2023

Abstract
Background
The rates of local failure after curative radiotherapy for prostate cancer (PC) remain high despite more accurate locoregional treatments available, with one third of patients experiencing biochemical failure and clinical relapse occurring in 30–47% of cases. Today, androgen deprivation therapy (ADT) is the treatment of choice in this setting, but with not negligible toxicity and low effects on local disease. Therefore, the treatment of intraprostatic PC recurrence represents a challenge for radiation oncologists. Prostate reirradiation (Re-I) might be a therapeutic possibility. We present our series of patients treated with salvage stereotactic Re‑I for intraprostatic recurrence of PC after radical radiotherapy, with the aim of evaluating feasibility and safety of linac-based prostate Re‑I.

Materials and methods
We retrospectively evaluated toxicities and outcomes of patients who underwent salvage reirradiation using volumetric modulated arc therapy (VMAT) for intraprostatic PC recurrence. Inclusion criteria were age ≥ 18 years, histologically proven diagnosis of PC, salvage Re‑I for intraprostatic recurrence after primary radiotherapy for PC with curative intent, concurrent/adjuvant ADT with stereotactic body radiation therapy (SBRT) allowed, performance status ECOG 0–2, restaging choline/PSMA-PET/TC and prostate MRI after biochemical recurrence, and signed informed consent.

Results
From January 2019 to April 2022, 20 patients were recruited. Median follow-up was 26.7 months (range 7–50). After SBRT, no patients were lost at follow-up and all are still alive. One- and 2‑year progression free survival (PFS) was 100% and 81.5%, respectively, while 2‑year biochemical progression-free survival (bFFS) was 88.9%. Four patients (20%) experienced locoregional lymph node progression and were treated with a further course of SBRT. Prostate reirradiation allowed the ADT start to be postponed for 12–39 months. Re‑I was well tolerated by all patients and none discontinued the treatment. No cases of ≥ G3 genitourinary (GU) or gastrointestinal (GI) toxicity were reported. Seven (35%) and 2 (10%) patients experienced acute G1 and G2 GU toxicity, respectively. Late GU toxicity was recorded in 10 (50%) patients, including 8 (40%) G1 and 2 (10%) G2. ADT-related side effects were found in 7 patients (hot flashes and asthenia).

Conclusion
Linac-based SBRT is a safe technique for performing Re‑I for intraprostatic recurrence after primary curative radiotherapy for PC. Future prospective, randomized studies are desirable to better understand the effectiveness of reirradiation and the still open questions in this field.
Immediate extubation after single-stage laryngotracheal reconstruction for subglottic stenosis in children
Authors: Tang XinYe , Yang Yang , Zhang ZhiHai , Sun Rong 
Published: February 2023

Abstract
Purpose
To evaluate the feasibility and clarify the appropriate indications for extubation immediately after single-stage laryngotracheal reconstruction (SS-LTR) in pediatric subglottic stenosis (SGS).

Methods
A retrospective study was performed from July 2017 to July 2022. All patients underwent SS-LTR with anterior costal cartilage graft. Information such as demographics, comorbidities, history of intubation or tracheostomy, Classification and grading of airway stenosis, the operation-specific decannulation rate and overall decannulation rate were analyzed.

Results
Twenty-two patients with simple SGS were identified. The median age at SS-LTR was 19 months (IQR = 18.5 months). Fourteen patients (63.6%) were intubated prior to the presentation of symptoms. Fourteen patients (63.6%) required preoperative tracheostomy to maintain a secure airway. Eight patients (36.4%) had congenital SGS, 10 patients (45.5%) had acquired SGS, and 4 patients (18.2%) had mixed SGS. Three patients had Grade II stenosis. Nineteen patients had Grade III stenosis. Comorbidities were found in 10 patients (45.5%). Major comorbidities were pneumonia. Congenital airway anomalies were found in 6 patients (27.3%). After anesthesia, all 22 patients were successfully extubated and returned to the general ward. Twenty patients had a satisfactory airway after SS-LTR. Two patients required reintubation or tracheostomy after operation. Operation-specific decannulation rate was 90.9%. The overall decannulation rate is 100%.

Conclusion
SS-LTR with anterior costal cartilage graft is an effective method to treat simple SGS ranging from Grades I to III in children. Extubation immediately after surgery is safe and feasible.
Local drug delivery in the treatment of furcation defects in periodontitis: a systematic review
Authors: Chatzopoulos Georgios S. , Koidou Vasiliki P. , Tsalikis Lazaros 
Published: February 2023

Abstract
Objectives
To evaluate the effect of subgingival administration of various antimicrobials and host-modulating agents in furcation defects as an adjunct to scaling and root planing (SRP) compared to SRP alone or combined with placebo.

Methods
A systematic review was carried out using MEDLINE-PubMed, Embase, and Scopus for articles up to October 2022 in addition to hand searches. All longitudinal studies that evaluated the effect of subgingival application of antimicrobial and host-modulating agents in furcation defects as adjuncts to SRP compared to SRP alone or SRP + placebo with at least 3 months of follow-up were eligible for inclusion.

Results
A total of eight studies were included. Superior clinical treatment outcomes were shown when alendronate, rosuvastatin, boric acid, simvastatin, and tetracycline (only at 3 months) were utilized in furcation defects in conjunction with SRP alone or SRP + placebo. Significant improvement was reported in radiographic bone defect depth and defect depth reduction when SRP was supplemented with alendronate, rosuvastatin, boric acid, and simvastatin.

Conclusions
Within the limitations of this review, the adjunctive subgingival administration of medications and host-modulating agents in furcation defects may confer additional clinical and radiographic benefits than non-surgical periodontal treatment alone. Future investigations are needed to confirm their long-term effectiveness.

Clinical relevance
Local host modulators and antimicrobials may be used supplementary to enhance the clinical and radiographic treatment outcomes of conventional periodontal therapy in furcation defects.
Clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteraemia
Authors: Papadimitriou-Olivgeris Matthaios , Jacot Damien , Senn Laurence , Guery Benoit 
Published: February 2023

AbstractThis retrospective study, conducted at Lausanne University Hospital (2015–2021), compared Staphylococcus aureus bacteraemia (SABA) patients with or without concomitant bacteriuria (SABU). Among 448 included bacteraemic patients, 62 (13.8%) had S. aureus concurrently isolated from urine. In multivariate analysis, there was a significant difference in the odds of community-onset bacteraemia (P 0.030), malignancy (P 0.002), > 1 pair of positive blood cultures (P 0.037), and persistent bacteraemia for at least 48 h (P 0.045) in patients with concurrent SABU. No difference concerning mortality was found. On the other hand, SABU was associated with higher rates of SABA recurrence after antibiotic cessation.
Induced earthquakes and house prices: the role of spatiotemporal and global effects
Authors: Durán Nicolás , Elhorst J. Paul 
Published: February 2023

AbstractThis paper contributes to the existing literature on the explanation of housing prices. First, our proposed methodology accounts for cross-sectional dependence, both locally and globally, using individual data of more than 200,000 transactions in the three most northern provinces of the Netherlands over the period 1993–2014. Second, the selection of houses within each focal house’s sub-market is not only based on distance and time, but also on their degree of similarity. Third, global cross-sectional dependence is not modeled by time-fixed effects, as in previous studies, but by cross-sectional price averages. Fourth, we accumulate the strength and frequency with which earthquakes affect each focal house before it was sold into one single measure using a seismological model and then subdivide it into different bins to account for nonlinear effects and to determine a threshold below which earthquakes have no effect. This way we are able to investigate the propagation of the detrimental impact of earthquakes on housing prices over space and time without the need to select a reference area in advance, which potentially might also have been affected by earthquakes.
caSPiTa: mining statistically significant paths in time series data from an unknown network
Authors: Tonon Andrea , Vandin Fabio 
Published: February 2023

AbstractThe mining of time series data has applications in several domains, and in many cases the data are generated by networks, with time series representing paths on such networks. In this work, we consider the scenario in which the dataset, i.e., a collection of time series, is generated by an unknown underlying network, and we study the problem of mining statistically significant paths, which are paths whose number of observed occurrences in the dataset is unexpected given the distribution defined by some features of the underlying network. A major challenge in such a problem is that the underlying network is unknown, and, thus, one cannot directly identify such paths. We then propose caSPiTa, an algorithm to mine statistically significant paths in time series data generated by an unknown and underlying network that considers a generative null model based on meaningful characteristics of the observed dataset, while providing guarantees in terms of false discoveries. Our extensive evaluation on pseudo-artificial and real data shows that caSPiTa is able to efficiently mine large sets of significant paths, while providing guarantees on the false positives.
Do students’ personality traits change during medical training? A longitudinal cohort study
Authors: Abbiati Milena , Cerutti Bernard 
Published: February 2023

AbstractMany medical schools incorporate assessments of personal characteristics, including personality traits, in their selection process. However, little is known about whether changes in personality traits during medical training affect the predictive validity of personality assessments. The present study addressed this issue by examining the stability of personality traits and their predictive validity over a 6-year medical training course. Participants were two cohorts of Swiss medical students (N = 272, 72% of students admitted to Year 2) from whom we collected demographic data, Swiss medical studies aptitude test (EMS) scores, Big Five personality traits scores measured at three times and scores on the multiple-choice and objective structured clinical examination parts of the final medical examination. Our findings indicated that personality traits had medium-to-high rank-order stability (r > .60 over 3 years and r > .50 over 6 years). Mean-level changes were moderate for agreeableness (d = + 0.72) and small for neuroticism and conscientiousness (d = -0.29, d = -0.25, respectively). Individual reliable change indices ranged from 4.5% for openness to 23.8% for neuroticism. The predictive validity was similar to that of the first three years of follow-up. To the best of our knowledge, this is the first study to investigate changes in personality across undergraduate curriculum. Medical students’ personality traits were mostly stable across medical school and retain their predictive validity. Consequently, this study supports the use of tools measuring constructs underlying personality traits in selection. In addition, this study confirms that examination formats could favor students with certain personality traits.
Colloidal silver against macrophage infections and biofilms of atypical mycobacteria
Authors: Feizi Sholeh , Cooksley Clare M. , Ramezanpour Mahnaz , Nepal Roshan , Psaltis Alkis J. , Wormald Peter-John , Vreugde Sarah 
Published: February 2023

AbstractSkin and soft tissue infection (SSTI) caused by atypical mycobacteria such as Mycobacterium abscessus and Mycobacterium avium intracellulare complex (MAIC) have increased in recent years. Current therapeutic options are limited, and hence new and better therapies are urgently required. Colloidal Silver (CS) has been identified for its widespread antibacterial properties and silver-impregnated dressings have been used for SSTIs caused by various pathogens. The efficacy of Green Synthesized Colloidal Silver (GSCS) was investigated for bacterial growth inhibition (BGI) using a microdilution method and minimum biofilm eradication concentration (MBEC) using resazurin assay and confocal scanning laser microscopy (CSLM) of M. abscessus (n = 5) and MAIC (n = 5). The antibacterial effect of GSCS against M. abscessus infected macrophages was also evaluated. The in vitro cytotoxicity of GSCS on a human keratinocyte cell line (HaCaT) and neonatal foreskin fibroblasts was analyzed by the crystal violet proliferation assay. Average BGI and MBEC of GSCS varied between 0.7 and 22 ppm for M. abscessus and MAIC. The concentration of 3 ppm reduced M. abscessus-infection in macrophages significantly. GSCS was not cytotoxic to HaCaT and neonatal foreskin fibroblast cells at concentrations < 3 ppm up to 2 h exposure time. GSCS therefore, has the potential for topical application against atypical mycobacterial SSTI.
Implications of strategic position choices by candidates
Authors: Robinette Robbie 
Published: February 2023

AbstractI examine the implications of strategic position choices by candidates under two different voting rules: Instant Runoff and Condorcet-Minimax. A neural net forecasts the chances of winning at different ideologies and candidates alter their ideology to maximize their expected utility. This results in different candidate behavior and outcomes than in the non-strategic scenario. Further, the maximal utility strategy differs significantly between the two voting rules being examined. I propose a refinement to the social utility efficiency metric to account for the different utility of the candidate’s chosen positions and use this metric to contrast the outcomes. Finally, this divergence in strategy calls into question the practice of using data (ballots, or survey data) gathered under one voting rule to analyze a different voting rule.
The Long-Term Effects of the COVID-19 Pandemic on Children’s Writing: a Follow-up Replication Study
Authors: Skar Gustaf B. , Graham Steve , Huebner Alan 
Published: February 2023

AbstractThe COVID-19 pandemic and the move by governments worldwide to cancel in-class instruction and move to emergency remote instruction in March and April of 2020 created an unprecedented disruption in children’s education. As the COVID-19 pandemic took form and continued to impact education in the following 2020/2021 academic year, multiple concerns were raised about possible negative effects on students’ learning. The current longitudinal replication study examined this proposition for second-grade students in Norway. In a previous investigation (Skar et al. Journal of Educational Psychology 114:1553–1566, 2022), we found that scores for quality of writing, handwriting fluency, and attitude toward writing of first-grade children tested immediately after emergency remote instruction ended in the Spring of 2020 (During COVID-19 cohort) were lower than the scores of first-grade students from the same schools tested a year earlier before the start of the pandemic (Before COVID-19 cohort). In the present study, we compared the scores for the During COVID-19 cohort (333 girls, 308 boys) on these same writing measures 1 year later at the end of second grade to a During COVID-19 cohort of second-graders (888 girls, 780 boys) from the same schools tested 2 years earlier before the start of the pandemic. The initial negative impact of the COVID-19 pandemic on first-grade students’ writing observed by Skar et al. (Journal of Educational Psychology 114:1553–1566, 2022) was no longer evident 1 year later at the end of second grade in the current study.
Thalidomide as an Effective Treatment in Sideroblastic Anemia, Immunodeficiency, Periodic Fevers, and Developmental Delay (SIFD)
Authors: Li Yan , Deng Mengyue , Han Tongxin , Mo Wenxiu , Mao Huawei 
Published: February 2023

Abstract

Purpose
Sideroblastic anemia, immunodeficiency, periodic fevers, and developmental delay (SIFD) is an autosomal recessive syndrome caused by biallelic loss-of-function variant of tRNA nucleotidyl transferase 1 (TRNT1). Efficacious methods to treat SIFD are lacking. We identified two novel mutations in TRNT1 and an efficacious and novel therapy for SIFD.

Methods
We retrospectively summarized the clinical records of two patients with SIFD from different families and reviewed all published cases of SIFD.

Results
Both patients had periodic fever, developmental delay, rash, microcytic anemia, and B cell lymphopenia with infections. Whole-exome sequencing of patient 1 identified a previously unreported homozygous mutation of TRNT1 (c.706G > A/p.Glu236Lys). He received intravenous immunoglobulin (IVIG) replacement and antibiotics, but died at 1 year of age. Gene testing in patient 2 revealed compound heterozygous mutations (c.907C > G/p.Gln303Glu and c.88A > G/p.Met30Val) in TRNT1, the former of which is a novel mutation. Periodic fever was controlled in the first month after adalimumab therapy and IVIG replacement, but recurred in the second month. Adalimumab was discontinued and replaced with thalidomide, which controlled the periodic fever and normalized inflammatory markers effectively. A retrospective analysis of reported cases revealed 69 patients with SIFD carrying 46 mutations. The male: female ratio was 1: 1, and the mean age of onset was 3.0 months. The most common clinical manifestations in patients with SIFD were microcytic anemia (82.6%), hypogammaglobulinemia/B cell lymphopenia (75.4%), periodic fever (66.7%), and developmental delay (60.0%). In addition to the typical tetralogy, SIFD features several heterogeneous symptoms involving multiple systems. Corticosteroids, immunosuppressants, and anakinra have low efficacy, whereas etanercept suppressed fever and improved anemia in reports. Bone-marrow transplantation can be used to treat severe SIFD, but carries a high risk. In total, 28.2% (20/71) of reported patients died, mainly because of multi-organ failure. Biallelic mutations located in exon1-intron5 lead to more severe phenotypes and higher mortality. Furthermore, 15.5% (11/71) patients survived to adulthood. The symptoms could be resolved spontaneously in five patients.

Conclusions
Thalidomide can control the inflammation of SIFD and represents a new treatment for SIFD.