bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is it only about technology? The interplay between educational technology for mathematics homework, teaching practice, and students’ activities
Authors: Radović Slaviša 
Published: May 2023

AbstractCurrent research on the use of digital technology in education has overgrown. It is becoming clear that technology will not unfold its pedagogical potential outlined in the literature on its own. To harness its full benefits, it is paramount to thoroughly understand the educational context and underlying pedagogical principles. This research reports how an educational technology can support students’ knowledge development from homework mathematics learning practices for 11 to 14 year-old students. The article describes the shift learning goals from producing the correct answer to understanding how to address current and future mathematical challenges as an important interaction between educational technology, teaching practices and student learning activities. The study revealed specific features of technology integration with mathematics teaching and learning practices. The findings highlighted the effectiveness of digital support for homework activities, indicating that there were benefits only when students and teachers used the full range of features and engaged in the process. Finally, the report provides practical tips and ground rules that can contribute to the successful implementation of educational technology for homework activities.
I Wear a Fitbit™; Therefore, I Am a Bitfit: Exploring the Impact of a Fitbit™ Device on Exercise and Work-Related Wellbeing
Authors: Lasikiewicz Nicola , Scudds Annie 
Published: May 2023

AbstractWorkplace wellbeing initiatives supporting mental health often utilise wearable activity trackers to promote physical activity. However, evidence regarding their efficacy is limited. The current study explored the potential for a Fitbit™ to increase engagement in exercise and to moderate the effect of exercise on work-related wellbeing in full-time workers. Participants recorded their work-related wellbeing and physical activity for two consecutive weeks, one wearing a Fitbit™. Results indicated that participants engaged in fewer minutes of exercise when wearing a Fitbit™, and that exercise alone was not associated with better work-related wellbeing. Participants were more frustrated when they exercised but were not wearing a Fitbit™. Participants also reported greater temporal demand when wearing a Fitbit™, which was exacerbated when not engaging in exercise. However, Fitbit™ wear was also associated with greater work-related satisfaction, regardless of whether they had engaged in exercise that day. Our findings imply that wearing a Fitbit™ can moderate the impact of exercise on work-related wellbeing, suggesting that it is not the activity tracker or exercise alone, but the interaction between the two which is key. The potential for wearable trackers to be effective in improving health and wellbeing is more complex than previously anticipated and warrants further investigation.
Cadmium Reduction in Spring Wheat: Root Exudate Composition Affects Cd Partitioning Between Roots and Shoots
Authors: Affholder M. C. , Moazzami A. A. , Weih M. , Kirchmann H. , Herrmann A. M. 
Published: May 2023

AbstractCadmium (Cd) in cereals is one of the major sources of Cd intake by human diets, and solutions to reduce Cd concentrations in wheat still need to be developed. Plant breeding, by selecting low-Cd varieties, can be an important tool to reduce Cd in crops. Knowing the genotypic variation in Cd accumulation and furthering our understanding of the impact of root exudates composition on Cd accumulation in crops may provide valuable information for plant breeding. In this study, we selected nine spring wheat varieties and analysed the accumulation and distribution of Cd in shoots, roots, root surfaces and kernels in relation to their qualitative and quantitative composition of root exudates, determined by 1H-NMR (Proton Nuclear Magnetic Resonance). Results showed that the Cd concentration in shoots at an early stage could be used as a predictor for Cd concentration in kernels. Total Cd uptake was not correlated to the mobility of Cd in the rhizosphere, but total Cd was negatively correlated to Cd adsorbed at the root surface. Furthermore, (i) exudation of organic acids (primarily succinate and acetate) increased Cd concentration in shoots, and (ii) exudation of nucleosides, DNA (deoxyribonucleic acid) degradation products, increased Cd adsorption at the root surface. Therefore, root exudates composition should be taken into account when selecting for low-Cd wheat traits.
An Analytical Approach for Dispatch Operations of Emergency Medical Services: A Case Study of COVID-19
Authors: Liu Jing , Ouyang Ruilin , Chou Chun-An , Griffin Jacqueline 
Published: May 2023

Abstract
Emergency medical services (EMS) aims to deliver timely ambulatory care to incidents in communities. However, the operations of EMS may contend with suddenly increasing demands resulting from unexpected disasters such as disease outbreaks (e.g., COVID-19) or hurricanes. To this end, it usually requires better strategical decisions to dispatch, allocate, and reallocate EMS resources to meet the demand changes over time in terms of demographic and geographic distribution of incidents. In this study, we focus on the operation of the EMS resources (i.e., ambulance dispatch) in response to a demand disruption amid the COVID-19 pandemic. Specifically, we present a analytical framework to (1) analyze the underlying demographic and geographic patterns of emergency incidents and EMS resources; (2) develop a mathematical programming model to identify potential demand gaps of EMS coverage across different districts; and (3) provide a remedial reallocation solution to the EMS system with the existing ambulance capacity. The proposed method is validated with emergency response incident data in New York City for the first COVID-19 surge from March to April 2020. We found that it takes a long incident response time to scenes which reflects unexpected incident demands during COVID-19 surge. To cover such disruptive demands, ambulances need to be reallocated between service districts while meeting the response time standard. The proposed framework can be potentially applied to similar disruptive scenarios in the future and other operational systems disrupted by other disasters.

Highlights

We propose an analytical framework using optimization modeling and simulation techniques for EMS resource allocation in response to a demand disruption amid the COVID-19 pandemic.

We propose mathematical programming models to identify potential demand gaps of EMS coverage across different districts.

We provide a remedial reallocation solution to the EMS system with the existing ambulance capacity.
Molecular mechanism of ferulic acid and its derivatives in tumor progression
Authors: Bao Xingxun , Li Wei , Jia Ruixue , Meng Dandan , Zhang Hairong , Xia Lei 
Published: May 2023

AbstractCancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery, radiotherapy, chemotherapy, and new therapeutic methods such as targeted therapy and immunotherapy, which have been developed rapidly in recent years. Recently, the tumor antitumor effects of the active ingredients of natural plants have attracted extensive attention. Ferulic acid (FA), (3-methoxy-4-hydroxyl cinnamic), with the molecular formula is C10H10O4, is a phenolic organic compound found in ferulic, angelica, jujube kernel, and other Chinese medicinal plants but is also, abundant in rice bran, wheat bran, and other food raw materials. FA has anti-inflammatory, analgesic, anti-radiation, and immune-enhancing effects and also shows anticancer activity, as it can inhibit the occurrence and development of various malignant tumors, such as liver cancer, lung cancer, colon cancer, and breast cancer. FA can cause mitochondrial apoptosis by inducing the generation of intracellular reactive oxygen species (ROS). FA can also interfere with the cell cycle of cancer cells, arrest most cancer cells in G0/G1 phase, and exert an antitumor effect by inducing autophagy; inhibiting cell migration, invasion, and angiogenesis; and synergistically improving the efficacy of chemotherapy drugs and reducing adverse reactions. FA acts on a series of intracellular and extracellular targets and is involved in the regulation of tumor cell signaling pathways, including the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT), B-cell lymphoma-2 (Bcl-2), and tumor protein 53 (P53) pathways and other signaling pathways. In addition, FA derivatives and nanoliposomes, as platforms for drug delivery, have an important regulatory effect on tumor resistance. This paper reviews the effects and mechanisms of antitumor therapies to provide new theoretical support and insight for clinical antitumor therapy.
The language of power and the power of language. Analysis of propaganda’s narrative in Fahrenheit 451
Authors: Forni Lorena 
Published: May 2023

AbstractRay Bradbury’s book is a narrative, in a dystopian context, of how the language of power manages to be pervasive, to infiltrate reality, in people’s experiences, in the consciousness of an entire society, so as to powerfully transform the meanings of commonly used words, as well as the normative qualifications of acts and professions. A reflection will be proposed on some “semantic spies” present in Fahrenheit 451, to highlight the centrality of some uses of language, aimed at influencing not only the behaviour of the members but also at modifying some institutions, manipulating rules and procedures, for the benefit of those who social control operates by administering power. The proposed intervention will deal with the specific function of propaganda language. Finally, a reflection on the power of the word will be proposed, as a tool capable of fully understanding the present and allowing all individuals to lay the foundations for new social, legal and political realities for the future.
CYP2C19 Polymorphism in Ischemic Heart Disease Patients Taking Clopidogrel After Percutaneous Coronary Intervention in Egypt
Authors: Shawky Ahmed , Sabit Hussein , Nazih Mahmoud , Baraka Khalid , El-Zawahry Mokhtar 
Published: May 2023

AbstractBackgroundCardiovascular diseases (CVDs) are considered a leading cause of death worldwide. Allelic variation in theCYP2C19gene leads to a dysfunctional enzyme, and patients with this loss-of-function allele will have an impaired clopidogrel metabolism, which eventually results in major adverse cardiovascular events (MACE). Ischemic heart disease patients (n = 102) who underwent percutaneous cardiac intervention (PCI) followed by clopidogrel were enrolled in the present study.MethodsThe genetic variations in theCYP2C19gene were identified using the TaqMan chemistry-based qPCR technique. Patients were followed up for 1 year to monitor MACE, and the correlations between the allelic variations inCYP2C19and MACE were recorded.ResultsDuring the follow-up, we reported 64 patients without MACE (29 with unstable angina (UA), 8 with myocadiac infarction (MI), 1 patient with non-STEMI, and 1 patient with ischemic dilated cardiomyopathy (IDC)). Genotyping ofCYP2C19in the patients who underwent PCI and were treated with clopidogrel revealed that 50 patients (49%) were normal metabolizers for clopidogrel with genotypeCYP2C19*1/*1and 52 patients (51%) were abnormal metabolizers, with genotypesCYP2C19*1/*2(n = 15),CYP2C19*1/*3(n = 1),CYP2C19*1/*17(n = 35), andCYP2C19*2/*17(n = 1). Demographic data indicated that age and residency were significantly associated with abnormal clopidogrel metabolism. Moreover, diabetes, hypertension, and cigarette smoking were significantly associated with the abnormal metabolism of clopidogrel. These data shed light on the inter-ethnic variation in metabolizing clopidogrel based on theCYP2C19allelic distribution.ConclusionThis study, along with other studies that address genotype variation of clopidogrel-metabolizing enzymes, might pave the way for further understanding of the pharmacogenetic background of CVD-related drugs.
Distributions of random variables involved in discrete censored δ-shock models
Authors: Chadjiconstantinidis Stathis , Eryilmaz Serkan 
Published: May 2023

AbstractSuppose that a system is affected by a sequence of random shocks that occur over certain time periods. In this paper we study the discrete censored
$\delta$
-shock model,
$\delta \ge 1$
, for which the system fails whenever no shock occurs within a
$\delta$
-length time period from the last shock, by supposing that the interarrival times between consecutive shocks are described by a first-order Markov chain (as well as under the binomial shock process, i.e., when the interarrival times between successive shocks have a geometric distribution). Using the Markov chain embedding technique introduced by Chadjiconstantinidis et al. (Adv. Appl. Prob.32, 2000), we study the joint and marginal distributions of the system’s lifetime, the number of shocks, and the number of periods in which no shocks occur, up to the failure of the system. The joint and marginal probability generating functions of these random variables are obtained, and several recursions and exact formulae are given for the evaluation of their probability mass functions and moments. It is shown that the system’s lifetime follows a Markov geometric distribution of order
$\delta$
(a geometric distribution of order
$\delta$
under the binomial setup) and also that it follows a matrix-geometric distribution. Some reliability properties are also given under the binomial shock process, by showing that a shift of the system’s lifetime random variable follows a compound geometric distribution. Finally, we introduce a new mixed discrete censored
$\delta$
-shock model, for which the system fails when no shock occurs within a
$\delta$
-length time period from the last shock, or the magnitude of the shock is larger than a given critical threshold
$\gamma >0$
. Similarly, for this mixed model, we study the joint and marginal distributions of the system’s lifetime, the number of shocks, and the number of periods in which no shocks occur, up to the failure of the system, under the binomial shock process.
Kalikow decomposition for counting processes with stochastic intensity and application to simulation algorithms
Authors: Phi Tien Cuong , Löcherbach Eva , Reynaud-Bouret Patricia 
Published: May 2023

AbstractWe propose a new Kalikow decomposition for continuous-time multivariate counting processes, on potentially infinite networks. We prove the existence of such a decomposition in various cases. This decomposition allows us to derive simulation algorithms that hold either for stationary processes with potentially infinite network but bounded intensities, or for processes with unbounded intensities in a finite network and with empty past before zero. The Kalikow decomposition is not unique, and we discuss the choice of the decomposition in terms of algorithmic efficiency in certain cases. We apply these methods to several examples: the linear Hawkes process, the age-dependent Hawkes process, the exponential Hawkes process, and the Galves–Löcherbach process.
Management of attic retraction pockets
Authors: Honnurappa Vijayendra , Mahajan Nilesh , Vijayendra Vinay Kumar , Vassiliu Sofia , Redleaf Miriam 
Published: May 2023

AbstractObjectiveAttic retraction pockets, classified by degree of invasion and erosion, are reconstructed here as outlined by attic retraction pocket grade.MethodAttic retraction pocket grade, surgical management, subsequent conditions of tympanic membrane and middle ear, and improvement of air–bone gap pure tone average were recorded.ResultsOur management strategy, based on attic retraction pocket grade, was applied to 200 ears: 44 grade I ears had non-surgical management and 156 grade II–V ears had surgical management. All 200 ears were followed up for 36–240 months, showing only 1 attic retraction pocket reformation and 1 adhesive otitis media (complication rate of 1 per cent), and improved air–bone gaps (p< 0.05). An earlier series of 50 grade IV attic retraction pockets used atticotomy with epitympanic reconstruction. These showed attic retraction pocket recurrence or cholesteatoma onset in 34 ears (68 per cent). When these ears were revised per protocol, there was no evidence of cholesteatoma thereafter.ConclusionReconstruction of the ossicles and scutal defect according to attic retraction pocket grade shows long-term stability of the tympanic membrane, middle ear and hearing.
Development and external validation of a prognostic tool for nonsevere COVID-19 inpatients
Authors: Luo Ensi , Zhong Qingyang , Wen Yongtao , Cai Jie , Xie Xia , Zhou Lingjuan 
Published: May 2023

Abstract
To develop a machine learning model and nomogram to predict the probability of persistent virus shedding (PVS) in hospitalized patients with coronavirus disease 2019 (COVID-19), the clinical symptoms and signs, laboratory parameters, cytokines, and immune cell data of 429 patients with nonsevere COVID-19 were retrospectively reviewed. Two models were developed using the Akaike information criterion (AIC). The performance of these two models was analyzed and compared by the receiver operating characteristic (ROC) curve, calibration curve, net reclassification index (NRI), and integrated discrimination improvement (IDI). The final model included the following independent predictors of PVS: sex, C-reactive protein (CRP) level, interleukin-6 (IL-6) level, the neutrophil-lymphocyte ratio (NLR), monocyte count (MC), albumin (ALB) level, and serum potassium level. The model performed well in both the internal validation (corrected C-statistic = 0.748, corrected Brier score = 0.201) and external validation datasets (corrected C-statistic = 0.793, corrected Brier score = 0.190). The internal calibration was very good (corrected slope = 0.910). The model developed in this study showed high discriminant performance in predicting PVS in nonsevere COVID-19 patients. Because of the availability and accessibility of the model, the nomogram designed in this study could provide a useful prognostic tool for clinicians and medical decision-makers.
The plans for Tokyo Bay: the challenge of urban policy, 1950s–1990s
Authors: Hasegawa Junichi 
Published: May 2023

AbstractAt the conclusion of the 1950s in Japan, plans to reclaim and develop Tokyo Bay were proposed by the Japan Housing Corporation's president and a private think tank on economic affairs. The vision was incompatible with dispersion, the basic direction of the state's policy, so it was quickly rejected, but its legacy lived on as the trans-Tokyo Bay highway in 1997. This article argues that the lack of an effective national policy led to contradictory initiatives and divisions among the stakeholders, leaving open the way for the large-scale reclamation and development of Tokyo Bay.
A rare ventriculoarterial connection: double outlet of both ventricles
Authors: Genc Halise Z. , Ozyilmaz Isa , Baş Serap , Kose Banu , Ozturk Erkut , Hatemi Ali C. , Tanidir Ibrahim C. 
Published: May 2023

AbstractVentriculoarterial connection is one of the important points of the segmental approach to congenital cardiac malformations. Double outlet of both ventricles is a rare form where both great arterial roots override the interventricular septum. In this article, we aimed to draw attention to this very rare form of ventriculoarterial connection by presenting an infant case diagnosed using echocardiography, CT angiography, and 3-dimensional modelling.
Inkjet-printed broadband FSS-based absorber with improved absorption characteristics
Authors: Tirkey Manish Mathew , Gupta Nisha 
Published: May 2023

AbstractWe present the design for a thin planar microwave absorber depicting near unity absorption over a wide bandwidth. The absorber consists of a single layer of resistive frequency selective surface inkjet printed over a paper substrate and suspended over a grounded foam. We have been able to achieve 99.99% absorption of normally incident radiations from 9.7 to 11.74 GHz at an extremely low level of −40 dB absorption bandwidth. The proposed absorber is thin (0.22λ0 at the center frequency), polarization-insensitive, and presents −10, −20, −30, and −40 dB fractional bandwidths as 89.83%, 55.41%, 33.30%, and 19.03%, respectively. It is worth mentioning that the design of an absorber with such steep slopes is highly stringent and requires special attention. Finally, we have experimentally demonstrated the perfect broadband absorption characteristics with a fabricated prototype.
Active Deformation Pattern in the Western Flank of the Central Taurides, Southern Margin of the Central Anatolian Plateau: Inferences From Geomorphic Markers and Kinematic Indicators
Authors: Aykut Tunahan , Yıldırım Cengiz , Uysal I. Tonguç 
Published: May 2023

AbstractThe southwestern margin of the Central Anatolian Plateau corresponds to the upper crust of the subduction between African and Anatolian plates, with a high relief of up to 2 km. This mountainous region has distinctive geomorphological features and presents a unique setting to investigate the mechanism of orogenic plateau margin development related to subduction and topographic evolution around the Eastern Mediterranean. We present new kinematic data from exposed fault planes and tectonic landforms from high‐resolution digital elevation models to elucidate the deformation pattern and its relation with the crustal deformation. We evaluate the deformation pattern based on the spatial distribution of kinematic analyses and geomorphic markers like low relief upland surfaces, disrupted karst basins, knickpoints, and deep bedrock incisions from watershed to shoreline. Our geomorphic analysis reveals a post‐orogenic transient actively deforming topography. The geomorphic markers constrain long‐term surface uplift pattern with a mean cumulative surface uplift of 1,710 ± 50 m and shows an increasing trend from west to east, from 1,600 ± 50 to 1,800 ± 50 m. Our results suggest a dome‐like uplift pattern in the west‐east direction across the southern margin that reaches up to maximum cumulative uplift values in the quadrangle of Alanya‐Başyayla‐Ermenek‐Gazipaşa. Our kinematic measurements along the youngest generation of faults revealed an active NE‐SW extensional deformation across a broad 200 km zone in the north of the subduction. Our findings have significant implications for understanding the morphotectonic evolution and post‐orogenic deformation in the plateau margins and geodynamic evolution of the Eastern Mediterranean.
Potential Role of Mid‐Latitude Seaway on Early Paleogene Atlantic Overturning Circulation
Authors: Zhu Chenguang , Zhang Zhongshi , Zhu Chenyu , Zhang Jian 
Published: May 2023

AbstractThe role of the mid‐latitude seaway between the proto‐Paratethys and the North Sea on the early Paleogene ocean circulation is examined with a state‐of‐art earth system model. The early Eocene simulations here demonstrate that the open mid‐latitude seaway captures most relatively fresh surface water from the Arctic and Greenland‐Norwegian Sea and prohibits them from leaking into the Labrador Sea, thus benefiting the Atlantic meridional overturning circulation (AMOC). However, the closure of the seaway triggers the AMOC reduction as more relatively fresh surface water enters the Labrador Sea, and the AMOC finally shuts down. Together with geological reconstructions, our results also provide insights into understanding the evolution of the Atlantic‐Arctic oceanic gateways during the Paleogene.