bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predator preferences: a key to effective biological control design
Authors: Steven Winnie , Ombeni Kishimbo , Kweka Eliningaya J. , Kimirei Merikinoi , Cleopa, Cecilia 
Published: June 2023

Objetctive: This experimental study aimed to assess the preference of Gambusia affinis to mosquito larvae of An.gambiae s.s., Cx. quinquefasciatus and Aedes aegypti. Method: Three Gambusia affinis were introduced in a glass container with a dimension of 45cm x 25cmx 25cm. Three larvae densities were used, 90 (30 larvae per species), 120 (40 larvae per species), and 180 (60 larvae per species). Each density experiment was set in triplicate and monitored after 1, 2, 3, and 24 hours. No fish food was added to the container for larvae. Results: Results have shown that in all times A. aegypti has been the most preferred species by Gambusia affinis. Among the tested species, A. aegypti was most prayed with time and in different densities. In mixed models including density, species, and time there was no significant difference among the species predation. Conclusion: Preliminary results have shown that the appropriate choice of predators for each mosquito species can have a great impact on bio-control to substantially complement existing tools.
Public awareness and knowledge of palliative care in Jordan
Authors: Abuelzeet Amaleid Y , Zeilani Ruqayya , Othman Elham H 
Published: June 2023

Background: Public perceptions of palliative care (PC) are crucial to enhance access to PC services and foster a sense of control over health decisions for people at the end of life. Purpose: To assess public knowledge of PC in Jordan. Method: A descriptive cross-sectional design with a stratified self-administered sample of 430 Jordanian citizens from all sectors in Jordan was used. Participants filled out the Palliative Care Knowledge Scale questionnaire. Data were analysed using IBM Statistical Package for the Social Sciences Statistics; descriptive, t-test, analysis of variance and regression test. Results: The mean score on the 13-item Palliative Care Knowledge Scale was 3.51±4.71 (out of 13). This indicates a low level of knowledge about PC among participants; 78.6% (n=338) of the participants had not heard about PC. Participants who worked in health fields, had post-graduate degrees and a high income showed higher awareness of PC than others in the study. Most participants learnt about PC from family members. Conclusion: There is a lack of knowledge of palliative care in Jordanian public society. There is a crucial need to raise public awareness, and implement educational interventions to improve public awareness about palliative care.
HUBUNGAN ANTARA KETERLIBATAN SISWA DENGAN KENAKALAN REMAJA PADA SISWA KELAS XI DI SMA TARUNA NUSANTARA
Authors: Saraswati Monica Nabila 
Published: June 2023

Penelitian ini dilaksanakan dengan tujuan mengetahui hubungan antara keterlibatan siswa dengan kenakalan remaja pada siswa kelas XI di SMA Taruna Nusantara. Kenakalan remaja merupakan menyimpang dari norma-norma sosial di lingkungan tempat remaja itu tinggal. Keterlibatan siswa merupakan keterlibatan siswa sebagai aktivitas sekolah, yaitu aktivitas akademik maupun non-akademik yang melibatkan keterlibatan kognitif, emosi, dan perilaku. Partisipan dalam penelitian ini adalah 169 siswa kelas XI SMA Taruna Nusantara Teknik sampling yang digunakan dalam penelitian ini adalah convenience sampling. Alat ukur yang digunakan adalah skala kenakalan remaja (20 aitem, α= 0,879) dan skala keterlibatan siswa (26 aitem, α=0,894). Analisis data menggunakan analisis statistik non parametrik Spearman’s Rhomenunjukan adanya hubungan negatif yang signifikan antara keterlibatan siswa dengan kenakalan remaja pada siswa kelas XI di SMA Taruna Nusantara. (rxy = -0,789; p < 0,001). Semakin tinggi keterlibatan siswa siswa SMA Taruna Nusantara, maka semakin rendah kenakalan remaja. Sebaliknya, semakin rendah keterlibatan siswa siswa SMA Taruna Nusantara, maka semakin tinggi kenakalan remaja.
MENAKAR PEMAAFAN PADA PENYINTAS CYBERBULLYING
Authors: Setyawan Imam 
Published: June 2023

The purpose of this study is to see an overview of cyberbullying survivors' forgiveness in post-pandemic life. This research uses a quantitative descriptive approach. The research subjects were obtained through a purposive sampling technique, with characteristics, students who are cyberbullying survivors, with an age range of 18-21 years. Screening is carried out with a cyberbullying questionnaire containing questions related to self-identity, types of cyberbullying (based on Willard's theory namely, flaming, harassment, denigration, impersonation, outing & trickery, exclusion, and cyberstalking), repeated experiences of cyberbullying, and perpetrators of cyberbullying, to ensure that the subject is truly are truly survivors of one or more types of cyberbullying. The research subjects were 109 students who were obtained from the screening results and statements of willingness. Data collection uses a scale of forgiveness (25 items, α = .931). Data analysis was performed using the Statistical Packages for Social Sciences (SPSS) version 26.0 program. The results showed that the subject's forgiveness was in the medium category, with a total of 62 people (57%), and the empirical mean was 58.16, within the medium category range (50 – 75). These results indicate that the forgiveness of cyberbullying survivors is not optimal, there are still 32 people (29%), in the low category. This condition occurs because most of the subjects are dealing with more than one type of cyberbullying, as well as the anonymity factor of the perpetrators of cyberbullying, most of whom come from strangers. No significant differences were found between male and female survivors' forgiveness.
Invasive and noninvasive markers of human skeletal muscle mitochondrial function
Authors: Mancilla Rodrigo , Pava‐Mejia Diego , van Polanen Nynke , de Wit Vera , Bergman Maaike , Grevendonk Lotte , Jorgensen Johanna , Kornips Esther , Hoeks Joris , Hesselink Matthijs K. C. , Schrauwen‐Hinderling Vera B. 
Published: June 2023

AbstractMitochondria are organelles that fuel cellular energy requirements by ATP formation via aerobic metabolism. Given the wide variety of methods to assess skeletal muscle mitochondrial capacity, we tested how well different invasive and noninvasive markers of skeletal muscle mitochondrial capacity reflect mitochondrial respiration in permeabilized muscle fibers. Nineteen young men (mean age: 24 ± 4 years) were recruited, and a muscle biopsy was collected to determine mitochondrial respiration from permeabilized muscle fibers and to quantify markers of mitochondrial capacity, content such as citrate synthase (CS) activity, mitochondrial DNA copy number, TOMM20, VDAC, and protein content for complex I–V of the oxidative phosphorylation (OXPHOS) system. Additionally, all participants underwent noninvasive assessments of mitochondrial capacity: PCr recovery postexercise (by 31P‐MRS), maximal aerobic capacity, and gross exercise efficiency by cycling exercise. From the invasive markers, Complex V protein content and CS activity showed the strongest concordance (Rc = 0.50 to 0.72) with ADP‐stimulated coupled mitochondrial respiration, fueled by various substrates. Complex V protein content showed the strongest concordance (Rc = 0.72) with maximally uncoupled mitochondrial respiration. From the noninvasive markers, gross exercise efficiency, VO2max, and PCr recovery exhibited concordance values between 0.50 and 0.77 with ADP‐stimulated coupled mitochondrial respiration. Gross exercise efficiency showed the strongest concordance with maximally uncoupled mitochondrial respiration (Rc = 0.67). From the invasive markers, Complex V protein content and CS activity are surrogates that best reflect skeletal muscle mitochondrial respiratory capacity. From the noninvasive markers, exercise efficiency and PCr recovery postexercise most closely reflect skeletal muscle mitochondrial respiratory capacity.
A Study of Russian Artifacts in the Collection of Imperial Palace in the Qing Dynasty
Authors: Duo Limei 
Published: June 2023

Abstract
This article systematically examines the Russian cultural relics in the collection of the Qing imperial palace and analyzes the remnants of interactions between the Qing court and the Russian court during the reigns of Peter the Great, Nicholas I, and Nicholas II. Russian cultural relics witnessed significant historical events such as the establishment of diplomatic relations between China and Russia, exchange of envoys, and the signing of a series of treaties. They carried the mission of promoting the national cultures and advantageous industries of both countries at that time. In addition, these cultural relics have high aesthetic value and contain reliable and rich historical information.
Genetic analysis of sunflower fatty acids under optimum and water stressed conditions
Authors: Ghaffari Mehdi , Shariati Farnaz 
Published: June 2023

Abstract
In order to study the genetic control of sunflower fatty acids under optimum and water limited conditions a set of 12 sunflower hybrids were evaluated as randomized complete block design with three replications in two separate experiments during two years (2019 and 2020) in Karaj, Iran. The hybrids were obtained by crossing of four male sterile lines and three restorer lines as testers. Water limitation was imposed by water withholding during reproductive stage. Palmitic acid content was governed by both additive and non-additive effects and linoleic acid content by non-additive gene action under optimum and water limited conditions. Stearic acid content was controlled by both additive and non-additive effects in optimum but by additive effects under water limited condition. Oleic acid content was governed by non-additive factors in optimum, while by both additive and non-additive effects in water limited condition. Oil content and leaf temperature were inherited by additive and seed yield by additive and non-additive effects in both conditions. Relative water content and chlorophyll content were controlled by both additive and non-additive effects under optimum but by non-additive effects in water limited condition. According to these results hybrid breeding is suggested for improvement of main sunflower fatty acids under optimum and water limited condition except that selection-based methods for improvement of stearic acid content.
Breast cancer status, grading system, etiology, and challenges in Asia: an updated review
Authors: Tan Xiao Jian , Cheor Wai Loon , Cheng Ee Meng , Ab Rahman Khairul Shakir , Wan Muhamad Wan Zuki Azman , Leow Wai Zhe 
Published: June 2023

Abstract
The number of breast cancer incidences reported worldwide has increased tremendously over the years. Scoping down to Asia, in 2020, the reported incidences of breast cancer are appalling, comprising 1,026,171 cases, occupying up to 45.4% of cases across the globe. Breast cancer is a non-communicable disease, that emerges in variegated forms, self-subsistent, and the etiology is observed to be multifactorial, dependent on the individual reproductive pattern, hormonal factors, diet, physical activity, lifestyle, and exposure to certain advent procedures. Given this complexity, breast cancer is expected to undergo a persistent increment in the number of incidences in near future, exacerbating the public health quality, regardless of race, ethnicity, geographical subgroups, and socioeconomic. In this review article, the authors examine breast cancer in multiple facets, comprising the updated statistics on breast cancer, typically in Asia; etiology of breast cancer; diagnosis of breast cancer; grading system; and challenges in breast cancer from the country’s income perspective. Realizing the ever-increasing demand for quality treatment, here, the article also contemplates common therapies in breast cancer, such as breast-conserving therapy, mastectomy, postmastectomy radiation therapy, neoadjuvant chemotherapy, axillary surgery, chemotherapy, adjuvant medical therapies, biological and targeted therapies, and endocrine therapy. This review article intended to provide a brief yet broad panoramic view of breast cancer, to readers, ranging from newcomers, existing researchers, and relevant stakeholders in the topic of interest.
The inhibitory effects of lobaplatin, or in combination with gemcitabine on triple-negative breast cancer cells in vitro and in vivo
Authors: Jiang Chengyan , Zhang Ye , Xu Xiaoyu , Su Shanshan , Pan Huafeng , Jiang Aiqin 
Published: June 2023

Abstract

Objectives
To study the therapeutic effects of lobaplatin in combination with conventional chemotherapy drugs on triple-negative breast cancer (TNBC) cells.

Methods
We used the CCK-8 assay, flow cytometry, western blotting, and immunofluorescence staining methods to detect the effects of lobaplatin or in combination with gemcitabine on the survival, apoptosis, and cell cycle progression of TNBC cells. A cell-derived xenograft mouse model was used to verify the antitumor effects of lobaplatin alone or in combination with gemcitabine.

Results
Lobaplatin significantly inhibited MDA-MB-468 cell growth in vitro, either alone or in combination with gemcitabine. Lobaplatin arrested the cell cycle at the S phase, induced nuclear cell damage, and promoted apoptosis. Also, the percentage of apoptotic cells was greatly increased when lobaplatin was combined with gemcitabine. Cleaved Caspase-3 and Poly (ADP-Ribose) Polymerase-1 (PARP-1) fragments indicated that lobaplatin promoted apoptosis through the classical pathway. Lobaplatin effectively inhibited the growth of tumors in vivo. Compared with the vehicle group (567.6 ± 126.2 mm3), the tumor volume of the lobaplatin group (302.7 ± 131.6 mm3) was significantly reduced (p<0.01). The combination of lobaplatin and gemcitabine (207.7 ± 83.94 mm3) was a little better than lobaplatin alone in the inhibition of the transplanted tumor (p>0.05).

Conclusions
Lobaplatin alone or in combination with gemcitabine had significant inhibitory effects on MDA-MB-468 cells in vitro. Lobaplatin also significantly inhibited the growth of nude mice xenografts. The synergistic effect between lobaplatin and gemcitabine in vivo was minimal, perhaps due to the low dose of gemcitabine used.
Identification of cancer stem cells derived from U118MG and the involvement of LncRNA-DC and STAT3 in promoting their malignant transformation
Authors: Liu Qingxi , Lv Lihui , Leung Terry , Li Hui , Xiao Hairong , Lu Wange , Ma Wenjian 
Published: June 2023

Abstract

Objectives
Cancer stem cells (CSCs) are a subpopulation of cancer cells that share similarities with somatic stem cells. CSCs are believed to play a key role in carcinogenesis, metastasis, cancer relapse, and drug resistance. Despite their significant impacts, the specific biological markers for the identification of CSCs and their differentiation/transformation mechanisms have not yet been fully characterized.

Methods
Utilizing stem cell markers, the ability to differentiate in multiple directions, and resistance to radiotherapy and chemotherapy, CSCs were identified. To assess the variations in gene expression, gene alterations, protein expression, and cell proliferation between CSCs and U118MG glioma cells, second generation sequencing, Real-Time PCR, Western Blotting, and CCK-8 were employed.

Results
In this study, we identified a subset of CSCs in human U118MG glioma cells that expressed the stem cell biomarkers CD133+, OCT4+, and CD44+. These cells exhibited stem cell-like characteristics such as multilineage differentiation and resistance to chemical and radiation stresses. Notably, they can form neurons with electrical signals and sodium currents. Further study also revealed that the malignant growth of this CSC subset was controlled by long noncoding RNA (Lnc-DC) through the STAT3 pathway.

Conclusions
As a potential therapeutic approach, inhibiting Lnc-DC may be beneficial in hindering carcinogenesis and drug resistance, as it selectively targets the growth of CSCs.
The role of acetylation of histone H3 and H4 in oral squamous cell carcinoma
Authors: Li Lian , Tang Donge , Dai Yong 
Published: June 2023

Abstract
Oral squamous cell carcinoma (OSCC), which commonly develops in the tongue, buccal mucosa, and epithelium of the oral cavity, is the result of an accumulation of genetic and epigenetic alterations. In OSCC, other epigenetic alterations, such as histone modification were present. Histone modification can predict the prognosis of various cancers. Actually, the regulation and remodeling of chromatin structure caused by histone acetylation was crucial for the growth of tumors. Histone acetylation has received extensive research in OSCC, particularly histone H3 and H4. Additionally, the bulk of OSCC treatment plans focused on controlling the degree of histone acetylation. The acetylation sites of histone H3 and H4 that evolved in OSCC and the effects of these modifications on histone are therefore summarized below. Furthermore, the treatment of OSCC was implemented from the realization of normalizing histone acetylation levels in OSCC, and we summarized target drugs in the resumption of OSCC acetylation level. This review could help with understanding and treating OSCC.
Spiritual Care-Kompetenz in der Ausbildung – Skizze einer analytisch-konzeptionellen und empirisch-anwendungsbezogenen Untersuchung
Authors: Magin Susanne 
Published: June 2023

Zusammenfassung

Einleitung: Die Bereitstellung von Spiritual Care in der klinischen Praxis ist durch einen von den Gesundheitsfachpersonen wahrgenommenen Mangel an Spiritual Care-Kompetenz eingeschränkt.

Methode: Spiritual Care-Kompetenz wird im Rahmen der Ausbildung von Gesundheitsfachpersonen mithilfe zweier Untersuchungen beleuchtet. In einer analytisch-konzeptionellen Untersuchung erfolgt eine Begriffsklärung von Spiritual Care-Kompetenz, in einer empirisch-anwendungsbezogenen Untersuchung werden zwei Studien zur Spiritual Care-Kompetenz in der Ausbildung ausgewertet (Magin 2022c).

Ergebnisse: In der ersten Untersuchung wurden Bedeutungsdimensionen herausgearbeitet, die die Spiritual Care-Kompetenz charakterisieren. In der zweiten Untersuchung zeigte zum einen eine Analyse von Interviews, dass die Teilnahme an einem Online-Spiritual Care-Seminar zu Veränderungen in der Spiritual Care-Kompetenz führt. Zum anderen zeigte eine Fragebogenanalyse, dass Spiritual Care-Kompetenz ein veränderbares Konstrukt ist und die Teilnahme am Online-Spiritual Care-Seminar einen signifikanten Einfluss auf die wahrgenommene Spiritual Care-Kompetenz hat. In Zusammenführung beider Untersuchungen konnte das Gesamtverständnis von Spiritual Care-Kompetenz präzisiert werden: Spiritual Care-Kompetenz ist Relations- und Grenzsituationskompetenz und kann durch ein gezieltes Lehrangebot gefördert werden.

Diskussion: Die Ergebnisse sind sowohl für das Verständnis von Spiritual Care-Kompetenz als auch für die Aus- und Weiterbildung in Spiritual Care relevant. Um die Spiritual Care-Kompetenz unter Gesundheitsfachpersonen zu verbessern, gilt es, Spiritual Care-informierte Lehre auszubauen.
Machine learning approach for impedance locus uncertainties
Authors: Bifano Luca , Michel Markus , Weidl Max , Fischerauer Alice , Fischerauer Gerhard 
Published: June 2023

Abstract
This work deals with the determination of the uncertainty of measurement data, determined by electrical impedance spectroscopy. Four different types of sand were measured impedimetrically in a measuring cell designed as a plate capacitor in a frequency range from 20 Hz to 1 MHz. The measuring cell was filled ten times with each sand and 20 impedance spectra were recorded for each filling. The uncertainty at each frequency was determined from the measurement data. It was found that the measurement data variance with a given measuring-cell filling was negligibly small. However, it increased by a factor of up to 100 when the measuring cell was repeatedly emptied and re-filled with the same material. We propose a way to estimate a continuous approximation of the uncertainty band of the impedance locus in the complex plane from the discrete uncertainties at each frequency. It uses a Support Vector Machine (SVM) to generate a regression curve using the discrete uncertainties. The result of the regression was used to estimate the uncertainties of an average impedance locus. The said machine learning tool can handle large amounts of data, classes, and influencing variables. In this manner, it can help to identify cause-effect relationships. Furthermore, at the end of this work a possibility to estimate a continuous uncertainty band along the impedance locus curve via SVM regression is shown. This is an extension to the common methodology in literature, where the uncertainty is only determined at selected individual points of the impedance spectrum.
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
Authors: Karademir Mustafa , Doğan Halef O. , Sahin İnan Zeynep Deniz , Doğan Kübra , Kablan Demet 
Published: June 2023

Abstract

Objectives
Our study aimed to investigate the role of endoplasmic reticulum stress (ER) in brain damage following hepatic ischemia-reperfusion (HIR) injury. Specifically, we characterized the expression of markers of ER stress and histopathologic changes in the brain following HIR.

Methods
Twelve adults female Wistar rats were divided into two experimental groups equally. Group 1 was designed as the control group, and Group 2 was designed as the HIR group. Blood, liver, and brain tissue samples were collected during the sacrifice. The quantitative ELISA kits were used to detect glucose-regulated protein 78 (GRP-78), activating transcription factor 4 (ATF-4), eukaryotic initiation factor 2 alpha (EIF2-A), caspase-3, caspase-9, and CCAAT/enhancer-binding protein (CEBP) in plasma. Histopathological examination was performed for liver and brain tissues.

Results
Higher levels of GRP-78 (p=0.006), ATF4 (p=0.001), and EIF2-Α (p=0.007) were detected in group 2. More damage was detected in liver and brain samples in the histopathological examination of group 2 than in group 1.

Conclusions
Our results demonstrate that ER stress is involved in developing brain damage following hepatic ischemia-reperfusion injury, as evidenced by increased expression of markers of ER stress and neuronal injury.
Formação profissional e mundo do trabalho: reflexões a partir de um curso técnico em enfermagem
Authors: Ferraz Carmo Rose , Nathale Soares Amanda , Carneiro Luiz Brant , De Lima Ferreira Vargas Michely , Dias Bevilacqua Paula 
Published: June 2023

A articulação entre formação e mundo do trabalho norteou o desenvolvimento deste estudo cujo objetivo foi analisar aspectos educativos de um curso técnico em enfermagem e as implicações no trabalho de seus egressos. Foram realizadas entrevistas semiestruturadas com egressos, suas chefias imediatas, a coordenadora do curso e pedagogas que atuavam no curso. Os depoimentos foram tratados pela Análise de Conteúdo a partir das categorias processo educativo e trabalho. Formato, conteúdo e docentes foram bem avaliados pelos egressos. Foram destacadas a relevância da integração entre momentos de concentração e dispersão do curso para a construção gradual do conhecimento e as dificuldades de agregar, ao cotidiano de trabalho, conhecimentos, habilidades e vivências construídas durante o processo educativo. Entendemos que a Educação Permanente em Saúde constitui um caminho para superar essas dificuldades.