bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photocrosslinking of ethylene‐vinyl acetate (EVA)–polyethylene‐octene (POE) copolymer containing halogen‐free flame retardants
Authors: Morselli Giacomo , Villa Marco , Ceroni Paola , Medici Luca , Tarlazzi Fabio , Dossi Stefano , Matteucci Pietro , Galanti Andrea , Magrì Andrea 
Published: April 2023

AbstractPhotocrosslinking of polymers for industrial applications show undoubted advantages related to the mild conditions needed and the economical equipment. However, some issues include: the use of (i) mercury lamps as light sources, which poses concerns about safety and energy consumption, (ii) typical additives, such as halogen‐free flame‐retardant fillers (HFFR) are powdered materials, which can scatter UV photons and avoid a deep penetration of the light. In this study, we explore the UV‐curing of an innovative EVA‐POE blend containing hydrotalcite and aluminum hydroxide as HFFR in the presence of a 370‐nm UV LED, namely Ekopren® XI1321, a plastic used as coverage for electric cables. Two commercially available photoinitiators (benzophenone and ethyl Michler's ketone) were analyzed as well as two crosslinking coagents widely used in industry, that is, triallyl cyanurate and trimethylolpropane trimethacrylate. A comparison with pure EVA and LDPE was performed to show a higher cross‐linked content of the proposed blend, even in the presence of light scattering mineral fillers at high concentration.
A bio‐gel electric actuator prepared from tannic acid and carboxymethyl cellulose by green cross‐linking process with good output performance
Authors: Jia Weikun , Fang Fujian , Xu Yan , Ma Xueyan , Wang Lan 
Published: April 2023

AbstractIn this article, a chitosan‐based bio‐gel electric actuator with tannic acid and carboxymethyl cellulose (CMC)as cross‐linked materials was fabricated. By evaluating the output force and electrochemical characteristics of the electric actuator under different doping amounts of tannic acid and CMC, it was found that the sample with appropriate amount of cross‐linking can improve its output force, service life, specific capacitance. Infrared spectroscopy, scanning electron microscopy(SEM), and ion channel test showed that tannic acid and CMC were uniformly distributed in the chitosan matrix. The proper crosslinking was beneficial to transform the internal dense and uniform structure into a loose and porous structure, promote the migration of ions, improve the electrochemical performance of the electric actuator, and thereby improve its output performance. This study provided a facile and eco‐friendly method to construct chitosan‐based electromotive membrane with enhanced output properties.
One amino acid drives the lipid droplet targeting sequence of a new noncoding RNA‐encoded protein to mitochondrion
Authors: Yuan Quan , Zheng Kaixuan , Huang Ting , Zhi Zelun , Xu Yilu , Cui Liujuan , Liu Pingsheng , Zhang Shuyan 
Published: April 2023

AbstractOver the past decade, the majority of the mammalian genome considered to be noncoding has been revealed to be able to produce proteins. Many RNA molecules, mis‐annotated as noncoding, actually are predicted to code for proteins. Some of those proteins have been identified and verified to play critical roles in multiple biological processes. The lipid droplet (LD) is a unique cellular organelle bound with a phospholipid monolayer membrane, and is closely associated with cellular lipid metabolism and metabolic disorders. However, it is still unclear how a protein targets to LDs. Here we identified a new protein on LDs, LDANP2, which is encoded by noncoding RNA, through a proteomics‐based strategy. The key sequence for its localization on LDs, Truncation 3, is predicted to form an amphipathic helix. Surprisingly, the deletion of the first amino acid in Truncation 3 resulted in mitochondrial localization. How the types of amino acids would determine the LD or mitochondrial localizations of the protein was studied. The findings introduce a useful strategy to mine for new proteins and would provide clues to the understanding of how a protein would find its right organelle, with phospholipid monolayer or bilayer membrane.
FIGHT‐PD: A feasibility study of periodized boxing training for Parkinson disease
Authors: Blacker David J. , Fazio Raimondo , Tucak Claire , Beranek Phillip , Pollard Connor , Shelley Tegan , Rajandran Sanathraj , Holbeche Georgina , Turner Mitchell , Cruickshank Travis 
Published: April 2023

AbstractBackgroundBoxing training has become a popular form of exercise for people with Parkinson disease (PD). There is a dearth of high‐quality feasibility, safety, and efficacy data on boxing training for PD. Feasibility of Instituting Graduated High‐intensity Training (FIGHT‐PD) aimed to examine these features in a periodized boxing training program featuring high‐intensity physical and cognitive demands.ObjectiveTo conduct a feasibility study, aiming to address deficiencies in the current knowledge base and to provide data for future studies.DesignSingle‐arm, open‐label feasibility.SettingUniversity department and medical research institute.ParticipantsTen people with early stage PD without contraindications to intense exercise, identified from a database of participants interested in boxing training.InterventionsA 15‐week exercise program with three 1‐hour sessions per week, with each session including warmup and then rounds of noncontact boxing using a training device. Three distinct blocks of 5 weeks including active rest.
Boxers Development: focus on training technique
Boxers Cardio: increasing intensity, including high‐intensity interval training
Boxers Brain: focus on cognitively challenging dual task training
Main Outcome MeasuresProcess, resource, and management measures including recruitment and retention rates, timelines and costs, and compliance with prescribed exercise targets. Clinical outcomes were safety (adverse events), training intensity (using heart rate and perceived exertion monitoring), tolerability (pain, fatigue, and sleep scores), and pre‐ and postprogram Unified Parkinson Disease Rating Scale (UPDRS‐III).ResultsAmong 10 participants from a pool of 82 (recruitment rate = 12%), there were no withdrawals; 348/360 workouts were completed (adherence = 97.7%); 4/348 (1.1%) workouts were missed due to minor injury. Nine of 10 participants showed improvement in UPDRS motor score.ConclusionsFIGHT‐PD provides a depth of feasibility and safety data, methodological detail, and preliminary results that is not described elsewhere and could provide a useful basis for future studies of boxing training for PD.
Hillslope erosional features and permafrost dynamics along infrastructure in the Arctic Foothills, Alaska
Authors: Stephani Eva , Darrow Margaret M. , Kanevskiy Mikhail , Wuttig Frank , Daanen Ronald P. , Schwarber Jaimy A. , Doré Guy , Shur Yuri , Jorgenson Mark T. , Croft Peppi , Drage Jeremiah S. 
Published: April 2023

AbstractAbrupt thaw of ice‐rich permafrost in the Arctic Foothills yielded to the formation of hillslope erosional features. In the infrastructure corridor, we observed thermal erosion and thaw slumping that self‐healed near an embankment. To advance our understanding of processes between infrastructure and hillslope erosional features (INF‐HEF), we combined climate and remote sensing analyses to field investigations to assess an INF‐HEF system and validate our findings in a broader area along the infrastructure corridor. We identified that thaw consolidation along an embankment formed a thermokarst ditch that was ubiquitous in the broader study area, and which was extensively affected by shrubification and supported other positive feedback (e.g., snow accumulation, water impoundment, and weakened vegetation mat). The thermokarst ditch facilitated channelization of cross‐drainage water, thus increasing the terrain vulnerability to thermal erosion that evolved into thaw slumping after heavy rainfalls. The terrain resilience to thaw slumping benefited from the type of ground ice and topography prevailing at our site. The lateral discontinuity of massive ice in an ice‐wedge polygonal system (i.e., interchange soil and massive ice) compounded to a low‐slope gradient with topographic obstacles (e.g., baydzherakhs) decreased slumping activity and supported self‐stabilization.
The functional roles of m6A modification in prostate cancer
Authors: Zhang Fa , Chen Feng , Wang Chao , Zhou Feng‐Hai 
Published: April 2023

AbstractProstate cancer (PCa) is the most prevalent malignancy of the male genitourinary system, and its etiology suggests that genetics is an essential risk factor for its development and progression, while exogenous factors may have an significant impact on this risk. Initial diagnosis of advanced PCa is relatively frequent, and androgen deprivation therapy (ADT) is the predominant standard of care for PCa and the basis for various novel combination therapy regimens, and is often required throughout the patient's subsequent treatment. Although diagnostic modalities and treatment options are evolving, some patients suffer from complications, including biochemical relapse, metastasis and treatment resistance. Mechanisms of PCa pathogenesis and progression have been the focus of research. N6‐methyladenosine (m6A) is an RNA modification involved in cell physiology and tumor metabolism. It has been observed to affect the evolution of diverse cancers through the regulation of gene expression. Genes associated with m6A are prominent in PCa and are involved in multiple aspects of desmoresistant PCa occurrence, progression, PCa bone metastasis (BM), and treatment resistance. Here, we explore the role of m6A modifications in promoting PCa.
MicroRNA‐147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A
Authors: Natani Sirisha , Ramakrishna Maresha , Nallavolu Teja , Ummanni Ramesh 
Published: April 2023

AbstractBackgroundProstate cancer (PCa) is the leading cause of cancer related deaths in men, often androgen deprivation therapy (ADT) leads to the progression of androgen independent PCa (AIPC) which further leads to Neuroendocrine PCa (NEPC). Identifying the molecular mechanisms which navigate the neuroendocrine differentiation (NED) of PCa cells is clinically relevant. It has been suggested that the micro RNAs (miRNAs) play an important role in the regulation of intrinsic mechanisms relevant to tumor progression, resistance as a result leads to poor prognosis. miR‐147b has been transpiring as one of the deregulated miRNAs associated with the occurrence of multiple cancers. The present study has studied the role of miRNA‐147b in inducing NEPC.MethodsTo investigate the functional role of miR‐147b in NEPC, we have expressed miRNA mimics or inhibitors in PCa cells and monitored the progression of NEPC along with PCa cell proliferation and survival. The molecular mechanism miRNA‐147b follows was studied using western blot and reverse transcription polymerase chain analysis. miRNA target prediction using bioinformatics tools followed by target validation using luciferase reporter assays was performed.ResultsIn the present study, we found that miR‐147b is highly expressed in AIPC cell lines in particular neuroendocrine cells NCI‐H660 and NE‐LNCaP derived from LNCaP. Mechanistic studies revealed that overexpression of miR‐147b or miRNA mimics induced NED in LNCaP cells in in‐vitro while its inhibitor reversed the NE features (increased NE markers and reduced prostate specific antigen) of PC3, NCI‐H660 and NE‐LNCaP cells. In addition, miR‐147b reduced the proliferation rate of LNCaP cells via elevated p27kip1 and lowered cyclin D1 for promoting differentiation. In reporter assays, we have identified ribosomal protein S15A (RPS15A) is a direct target of miRNA‐147b and RPS15A expression was negatively regulated by miR‐147b in PCa cells. Furthermore, we also report that RPS15A is downregulated in NEPC cells and its expression is inversely correlated with NE markers.ConclusionTargeting the miR‐147b ‐ RPS15A axis may overcome the progression of NEPC and serve as a novel therapeutic target to attenuate NED progression of PCa.
Efficacy of entomopathogenic fungi, nematodes and spinetoram combinations for integrated management ofThrips tabaci
Authors: Wakil Waqas , Gulzar Sehrish , Prager Sean Michael , Ghazanfar Muhammad Usman , Shapiro‐Ilan David I 
Published: April 2023

AbstractBACKGROUNDTwo consecutive field trials using a blend of entomopathogens in combination with a new chemistry insecticide were conducted to determine treatment effects on onion thrips (Thrips tabaciLindeman) populations, crop damage, plant development, crop yield and impact on natural enemies. Products were tested in an onion cropping system and included the insect pathogenic fungusBeauveria bassiana(isolate WG‐11), an entomopathogenic nematodeHeterorhabditis bacteriophora(strainVS) and the new‐chemistry chemical insecticide spinetoram.RESULTSIn all treatments, a significant decrease in thrips per plant population was detected in both trials. Overall, dual application of entomopathogens and insecticide was more effective than singly applied treatments. The lowest number of thrips larvae (1.96 and 3.85) and adults (0.00 and 0.00) were recorded when treated with dual application ofB. bassianaand spinetoram at 7 days post application (DPA) after the second spray application in 2017and 2018, respectively. Damage on onion plants was considerably decreased in all treatments relative to the control. The lowest damage was observed on onion plants treated withB. bassiana + spinetoram at 7 DPA after the second spray application during both years. A significant decrease in the number of natural enemies (beetles, spiders, mites, lacewings, ants and bugs) on onion plants was recorded during both years. Insect pathogens when applied alone and in combination with each other considerably protected arthropod natural enemies compared to insecticide application applied alone. Significant increase in plant agronomic traits was observed compared to the control. Among all the treatments,B. bassiana + spinetoram produced maximum leaf length, leaf weight, total leaves, neck diameter, bulb diameter, number of rings per bulb, bulb weight, dry matter and plant yield following the 2017and 2018 applications, respectively.CONCLUSIONThe findings of the study reveal the potential of using insect pathogens and insecticide for control ofT. tabaci. However, combinations containing spinetoram are harmful to nontarget organisms, whereas biological control agents help in protecting biodiversity in onion agroecosystems. © 2023 Society of Chemical Industry.
Prevention effect of total ginsenosides and ginseng extract from Panax ginseng on cyclophosphamide‐induced immunosuppression in mice
Authors: Zhang He , Sun Yue , Fan Meiling , Zhang Yuyao , Liang Zuguo , Zhang Lancao , Gao Xiang , He Xinzhu , Li Xiangyan , Zhao Daqing , Sagratini Gianni , Su Hang , Qi Wenxiu 
Published: April 2023

AbstractOral decoction is widely applied in traditional Chinese medicines. The polysaccharides of decoction promote the exposure of small molecules and increase their bioavailability. This study mainly compared the component and activities of total ginsenosides (TGS) and ginseng extract (GE) on immunosuppressed mice induced by cyclophosphamide. Thirty‐two mice were randomly divided into control, model, TGS, and GE groups. The mice were orally administered for 28 days and then injected with cyclophosphamide on the last four days. The results of component analysis showed the total content of 12 ginsenosides in TGS (67.21%) was higher than GE (2.04%); the total content of 17 amino acids in TGS (1.41%) was lower than GE (5.36%); the total content of 10 monosaccharides was similar in TGS (74.12%) and GE (76.36%). The animal results showed that both TGS and GE protected the hematopoietic function of bone marrow by inhibiting cell apoptosis, and recovering the normal cell cycle of BM; maintained the dynamic balance between the Th1 and Th2 cells; also protected the spleen, thymus, and liver. Meanwhile, TGS and GE protected the intestinal bacteria of immunosuppressed mice by increasing the abundance of lactobacillus and decreasing the abundance of the odoribacter and clostridia_UCG‐014. The prevention effect of GE was superior to TGS in some parameters. In conclusion, TGS and GE protected the immune function of immunosuppressed mice induced by cyclophosphamide. Meanwhile, GE showed higher bioavailability and bioactivity compared with TGS, because the synergistic effect of polysaccharides and ginsenosides plays an important role in protecting the immune function.
Probabilistic interpretation of algebraic inequalities related to reliability and risk
Authors: Todinov Michael T. 
Published: April 2023

AbstractThe paper explores the probabilistic interpretations of algebraic inequalities and presents several findings. First, the inequality of the additive ratios can be used to increase the probability of an event occurring within a set of mutually exclusive and exhaustive events. The interpretation of this inequality produced a counter‐intuitive result, that for suppliers delivering the same quantity of reliable products alongside unknown numbers of unreliable products, the probability of purchasing a reliable product from a randomly selected supplier is higher than the probability of purchasing a reliable product from the market formed by all suppliers. Next, the paper discusses how averaging the reliabilities of components from different varieties can lead to a significant overestimation of the calculated system reliability, as demonstrated by another algebraic inequality interpretation. Finally, the paper derives tight bounds for the reliability of demand in a load‐strength interference model by interpreting the Hayashi's inequality. Notably, these bounds do not depend on the shape of the load distribution and only require the strength distribution to be known in relatively small vicinities of the lower and upper bound of the load.
Positioning failure error identification of industrial robots based on particle swarm optimization and Kriging surrogate modeling
Authors: Shen Wanghao , Liu Guojun , He Jialong , Li Guofa , Han Liangsheng 
Published: April 2023

AbstractTo tackle the low identification accuracy of robot positioning, this paper proposes a positioning failure error identification method for industrial robots, combining the Kriging surrogate model and the improved particle swarm optimization algorithm. First, based on the Denavit‐Hartenberg and the small displacement screw methods, the kinematic model of a six‐degree‐of‐freedom industrial robot with joint errors is constructed. Then, the Kriging surrogate model of the kinematic error is constructed, which is trained by generated training samples. Finally, the joint error identification of industrial robots is solved by an improved particle swarm optimization algorithm based on exponential inertia weight and sub‐population cooperation under the multi‐attitude positioning condition. The simulation results show that the proposed optimization algorithm can significantly improve the convergence accuracy and accurately identify the actual errors at each joint of the industrial robot.
Targeted alveo‐pleural fistula endobronchial valve treatment using ventilation scintigraphy
Authors: Sidhu Calvin , Ratnagobal Shoba , Thomas Rajesh , Lee Gary Y. C. , Drudy Enya , Francis Roslyn J. 
Published: April 2023

AbstractPersistent air‐leaks can be difficult to localize in radiology. Bronchoscopic management of air‐leaks requires identification of the leak's location to allow suitable targeted treatment. One‐way endobronchial valves have become a suitable option for persistent air‐leaks. In this report, a combination scintigraphy and one‐way endobronchial valve treatment successfully resolved a persistent air‐leak.
Nonlinear feedback switching rule design for sector‐bounded switched systems
Authors: Lunardi Henrique , Dezuo Tiago , Trofino Alexandre 
Published: April 2023

AbstractThis article presents a robust switching rule design technique for a class of nonlinear and uncertain switched systems. The approach is based on a state transformation that allows for nonlinear state feedback. The results are given in terms of linear matrix inequality problems and they guarantee global asymptotic stability of the closed‐loop system even if sliding modes occur on any switching surface. The class of systems considered is general enough to include multiple time varying sector‐bounded nonlinearities associated with real‐time changes in the operation point. The potential of the method is illustrated through photovoltaic systems, in which the nonlinear I–V characteristic of the modules is treated as a sector‐bounded function. As the slope of the sectors depend on the environmental conditions, robust sectors containing the nonlinearities for any uncertain uniform operation condition are derived.
A new formulation of sparse multiple kernel k$$ k $$‐means clustering and its applications
Authors: Qu Wentao , Xiu Xianchao , Sun Jun , Kong Lingchen 
Published: April 2023

AbstractMultiple kernel ‐means (MKKM) clustering has been an important research topic in statistical machine learning and data mining over the last few decades. MKKM combines a group of prespecified base kernels to improve the clustering performance. Although many efforts have been made to improve the performance of MKKM further, the present works do not sufficiently consider the potential structure of the partition matrix. In this paper, we propose a novel sparse multiple kernel ‐means (SMKKM) clustering by introducing a ‐norm to induce the sparsity of the partition matrix. We then design an efficient alternating algorithm with curve search technology. More importantly, the convergence and complexity analysis of the designed algorithm are established based on the optimality conditions of the SMKKM. Finally, extensive numerical experiments on synthetic and benchmark datasets demonstrate that the proposed method outperforms the state‐of‐the‐art methods in terms of clustering performance and robustness.
Pomegranate Peel Extract‐Mediated Green Synthesis of Silver Nanoparticles: Evaluation of Cytotoxicity, Antioxidant, and Anti‐esophageal Cancer Effects
Authors: Fu Yulei , Li Jianying , Almasi Maryam 
Published: April 2023

AbstractPomegranate is one of the popular fruits in Asian culture. Pomegranate has many pharmaceutical applications in folklore medicine. In the present study, the extract of the dried peel of pomegranate was used as a reducing agent for the green synthesis of silver nanoparticles. Various chemical methods such as FE‐SEM, XRD, and FT‐IR were used to characterize AgNPs. The results of XRD showed 45.55 nm for the crystal size of AgNPs. A spherical morphology was confirmed for the nanoparticles using FE‐SEM images with an average size of 63.15 nm the nanoparticles. In the cellular and molecular part of the recent study, the treated cells with AgNPs were assessed by MTT assay for 48 h about the cytotoxicity and anti‐human esophageal cancer properties on normal (HUVEC) and esophageal cancer cell lines i. e. KYSE‐30, KYSE‐50, KYSE‐70, KYSE‐110, KYSE‐270, OE33, ESO26 and FLO‐1. The IC50s of AgNPs were 487, 500, 435, 461, 285, 338, 253 and 288 μg/mL against KYSE‐30, KYSE‐50, KYSE‐70, KYSE‐110, KYSE‐270, OE33, ESO26 and FLO‐1 cell lines, respectively. The viability of malignant esophageal cell lines reduced dose‐dependently in the presence of AgNPs. It seems that the anti‐human esophageal cancer effect of recent nanoparticles is due to their antioxidant effects.