bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential diagnosis of familial adult myoclonic epilepsy
Authors: Baykan Betul , Franceschetti Silvana , Canafoglia Laura , Cavalleri Gianpiero L. , Michelucci Roberto , Scheffer Ingrid E. 
Published: February 2023

AbstractObjectiveFamilial adult myoclonic epilepsy (FAME) is an under‐recognized disorder characterized by cortical myoclonus, generalized tonic–clonic seizures, and additional clinical symptoms, which vary depending on the FAME subtype. FAME is caused by pentanucleotide repeat expansions of intronic TTTCA/TTTTA in different genes. FAME should be distinguished from a range of differential diagnoses.MethodsThe differential diagnoses and frequent presentations leading to misdiagnosis of FAME were investigated from the available literature and reported based on an expert opinion survey.ResultsThe phenotypic features of FAME, including generalized tonic–clonic and myoclonic seizures, are also seen in other epilepsy syndromes, such as juvenile myoclonic epilepsy, with a resultant risk of misdiagnosis and lack of identification of the underlying cause. Cortical myoclonus may mimic essential tremor or drug‐induced tremor. In younger individuals, the differential diagnosis includes progressive myoclonus epilepsies (PMEs), such as Unverricht‐Lundborg disease, whereas, in adulthood, late‐onset variants of PMEs, such as sialidoses, myoclonus epilepsy, and ataxia due to potassium channel pathogenic variants should be considered. PMEs may also be suggested by cognitive impairment, cerebellar signs, or psychiatric disorders. Electroencephalography (EEG) may show similarities to other idiopathic generalized epilepsies or PMEs, with generalized spike–wave activity. Signs of cortical hyperexcitability may be seen, such as an increased amplitude of somatosensory evoked potentials or enhanced cortical reflex to sensory stimuli, together with the neurophysiological pattern of the movement disorder.SignificanceRecognition of FAME will inform prognostic and genetic counseling and diagnosis of the insidious progression, which may occur in older individuals who show mild cognitive deterioration. Distinguishing FAME from other disorders in individuals or families with this constellation of symptoms is essential to allow the identification of underlying etiology.
Feature selection of surface topography parameters for fatigue‐damage detection using Pearson correlation method and neural network analysis
Authors: Alqahtani Hassan , Ray Asok 
Published: February 2023

AbstractThe global objective of this study was to investigate the best features of the surface topography for fatigue‐damage detection and classification. The presence of the stress concentration in valleys of the surface topography causes a grain slip and a crack initiation at the surface of the machined structure and finally leads to fatigue failures. Therefore, the surface topography has a major influence on the fatigue strength of the machined structure. An optical confocal measurement system (Alicona) was applied to measure six surface topography parameters. In this paper, feature selection using the Pearson correlation method was adopted to select the best surface textures that provide best the neural network (NN) model performance. The NN model is capable of detecting and classifying the damage with an accuracy of up to
94.4%.
Sarcopenia Definition Outcome Consortium – defined Weakness and Risk of Falls: The National Health and Aging Trends Survey
Authors: Batsis John A. , Haudenschild Christian , Crow Rebecca S. , Gilliam Meredith , Mackenzie Todd A. 
Published: February 2023

AimThe prevalence of obesity continues to rise, as does that of weakness. However, it is unclear how this impacts the risk of falling. We aimed to ascertain the risk of falls using new definitions of clinically defined weakness.MethodsWe applied clinically defined weakness definitions to the National Health and Aging Trends Survey using the Sarcopenia Definitions Outcomes Consortium cutpoints. Three exposure variables were created: grip‐strength‐defined weakness and body mass index [GS/BMI]‐defined obesity; weakness and obesity, weakness and waist circumference‐derived obesity (GS/WC); and weakness defined by a ratio of GS÷BMI. Proportional hazards modeled incident falls as a function of weakness with/without obesity (hazard ratio [HR] [95% confidence intervals]).ResultsOf 4906 respondents aged ≥ 65 years (54.5% female), the mean ± SD grip strength, BMI, and WC were 26.7 ± 10.6 kg, 27.4 ± 5.4 kg/m2, and 99.5 ± 16.3 cm, respectively. Using the neither weakness/obesity as the referent, weakness was associated with incident falls across all definitions (GS/BMI: HR 1.19 [1.07, 1.33]; GS/WC: HR 1.39 [1.19, 1.62]; GS ÷ BMI: HR 1.16 [1.05, 1.28]). Weakness with obesity was associated with falls using GS/WC (HR 1.28 [1.11, 1.48]). Obesity status was associated with falls in both the BMI and the WC definition (1.17 [1.02–1.35], 1.16 [1.05–1.28]).ConclusionOur findings further evaluate the definitions of clinically defined weakness with and without obesity in older adults. As falls are an important patient outcome, establishing this relationship is critical for both clinicians and researchers. Future study should identify high‐risk individuals in order to direct specific interventions to them. Geriatr Gerontol Int 2023; 23: 213–220.
Trajectory and cluster resilience elements: The case of the Brazilian wine cluster of the Serra Gaúcha
Authors: Schmidt Vitor Klein , Zen Aurora Carneiro , Soares Bernardo Fernandes , Bittencourt Bruno Anicet 
Published: February 2023

AbstractThe recent economic, technological, and social shocks have led to a period of high economic uncertainty. The term “economic resilience” has been used to describe how regional clusters deal with and adapt to various shocks. This paper aims to analyze the elements that influence the resilience trajectory of a cluster. We conduct qualitative and exploratory research on the centennial Wine Cluster in Serra Gaúcha, Brazil, using data sources, interviews, and documents. To this end, we first identify seven elements that influence cluster resilience from the literature review. Subsequently, through an empirical case study, we verify whether these elements could represent the resilience of clusters. The results show that these seven elements are integrable and represent dimensions that explain the resilience of the cluster analyzed. Moreover, the findings highlight that resilience and resistance to crises are the historical results of improvements and the development of new routines for clustered companies. This study contributes to the cluster resilience literature and presents elements explaining how regions can adapt to and deal with shocks.
Gender‐role preference matters: How family policy dissemination affects marriage/fertility intentions
Authors: Wang Senhu , Gong Shun 
Published: February 2023

AbstractDespite a wide range of family policies, marriage and fertility rates in Japan remain very low among developed countries. Drawing on data from a national survey experiment, this study aims to examine whether dissemination of existing family policies can increase marriage and fertility intentions of Japanese young individuals and whether the effect depends on their gender‐role preferences. The results show that informing and/or reminding respondents of the existing family policies can significantly increase their marriage intention, but not their fertility intention. Moreover, the effect on marriage intention is moderated by their gender‐role expectations for future spouses. Specifically, the policy information effect is more pronounced among women who expect a relatively equal share of financial responsibilities and among men who expect their future wives to assume the primary housework responsibilities. This suggests that although existing family policies may lower marriage costs for economically independent women, the same policies could potentially exacerbate domestic gender inequalities and women's work‐life conflicts by helping less domestically engaged men enter into marriage. Overall, these findings contribute to the feminist literature on gender and family by highlighting the potential consequences of family policies on the pre‐marriage mechanisms of domestic gender inequalities and calling for actions to change men's traditional gender ideology.
Patient preferences for attributes of injected or infused preventive migraine medications: Findings from a discrete choice experiment
Authors: Schwedt Todd J. , Martin Ashley , Kymes Steven , Talon Brian , Lee Xin Ying , Cady Roger , Asher Divya , Karnik‐Henry Meghana , Mulvihill Emily , Bates Dawn , Beusterien Kathleen 
Published: February 2023

AbstractObjectiveTo assess preferences among adults with migraine for differentiating attributes of injected or infused preventive treatment options and evaluate their importance in determining a treatment choice.BackgroundAdults with migraine and health‐care providers consider many factors when making treatment decisions. Injected or infused preventive migraine treatment options differ in several attributes, including mode of administration and dosing frequency, which may be preferentially selected or avoided by patients. Understanding a patient's preference is important for clinicians as they advise on various treatment options.MethodsA total of 604 US adults diagnosed with migraine participated in an online survey that captured information on demographics, migraine history, and treatment preferences. A discrete choice experiment (DCE) was used to evaluate participants’ preferences for specific attributes of injected/infused preventive migraine therapies. The DCE data were utilized to estimate attribute importance (expressed as a percentage) and identify subgroups that had different distributions of preferences.ResultsIn the overall migraine population, mode of administration (28.8%), durability of effectiveness (27.0%), and speed of onset (25.5%) had the highest relative importance, whereas administration setting (9.9%) and dosing frequency (8.8%) had the lowest. Four distinct subgroups were identified: Group 1 (n = 128) preferred self‐injection administration and durability of effectiveness; Group 2 (n = 189) expressed aversion to cranial injections; Group 3 (n = 158) prioritized rapid speed of onset; and Group 4 (n = 129) favored health‐care provider administration and durability of effectiveness.ConclusionsSpeed of onset, durability of effectiveness, and mode of administration are key moderators of treatment preference among US adults with migraine. Certain segments of the migraine population prioritize specific treatment attributes over others, with intravenous infusion not considered a barrier in three of four identified segments. Clinicians can best help their patients find the right medication if they understand which medication attributes are most and least important to them.
Development of SEDDS formulation containing caffeine for dermal delivery
Authors: de Almeida Igor de Andrade Assunção , Honório Thiago da Silva , do Carmo Flavia Almada , de Freitas Zaida Maria Faria , Simon Alice , Rangel Rodrigues Carlos , Pereira de Sousa Valeria , Cabral Lucio Mendes , de Abreu Letícia Coli Louvisse 
Published: February 2023

AbstractObjectiveThe objective of this work was to develop a self‐emulsifying drug delivery system (SEDDS) containing caffeine for the treatment of cellulite.MethodsSEDDS were prepared using the solution method. 0.5% (w/v) caffeine was added to the previously selected excipients. The system was characterized by droplet size, zeta potential, emulsification time and long‐term stability. In vitro release and skin permeation were investigated using Franz‐type diffusion cells. The cytotoxicity was evaluated on normal human keratinocytes.ResultsCaffeine SEDDS were thermodynamically stable, with a zeta potential less than ‐ 22 mV and droplet size around 30 nm, and were long‐term stable. The permeation study showed that the formulation promoted caffeine accumulation in the skin layers, suggesting an increase in local circulation. Cytotoxicity studies on HaCaT cells were not conclusive as the surfactant used indicated false‐positive results due to its high molar mass.ConclusionIt was possible to obtain a stable SEDDS that could cause an increase in blood flow in the applied area, resulting in cellulite reduction.
Relationship between skin fungal and bacterial microbiomes and skin pH
Authors: Akaza Narifumi , Takasaki Kazuto , Matsudaira Takahiro , Usui Atsuko , Iijima Anna , Miura Shiori , Yashiro Youichi 
Published: February 2023

AbstractObjectiveThe present study investigated the relationship between the skin bacterial and fungal microbiomes and skin pH at sebaceous sites, namely, the forehead, cheek and upper chest. We also examined the relationship between the skin microbiome and transepidermal water loss (TEWL), which is an indicator of rough skin.MethodsThirty healthy Japanese subjects (15 females and 15 males) were enrolled as subjects. The forehead, cheek and upper chest were examined in August (summer) and February (winter). Skin surface samples were collected using the swab method, and the 16s rRNA and ITS regions were analysed using next‐generation sequencing. Skin pH and TEWL were also assessed.ResultsThe changes observed in the skin microbiome were associated with season‐dependent changes in skin pH. An increase in skin pH at the forehead and cheek was associated with a higher relative abundance of Cutibacterium spp., a reduction in bacterial diversity, and a lower relative abundance of Staphylococcus spp. A decrease in skin pH at the upper chest was associated with a higher relative abundance of Malassezia restricta, a lower relative abundance of M. sympodialis and decrease in fungal diversity. Moreover, these changes were also associated with an increase in TEWL.ConclusionThe present results indicate that changes in skin pH are associated with changes in the skin bacterial and fungal microbiomes at sebaceous sites. The changes observed in the skin microbiome were also associated with rough skin.
International student mobility: A systematic review and research agenda
Authors: Luo Yunxin , Latukha Marina , Panibratov Andrei 
Published: February 2023

AbstractThis study aimed to synthesize fragmented knowledge about international student mobility (ISM) in higher education to provide an understanding of existing studies and directions for future research. To this end, the authors conducted a systematic literature review using a hybrid approach that integrated bibliometric analysis with the theory, context, and method (TCM) framework (Paul et al., Journal of World Business, 2017;52(3):327–342). Applying bibliometric analysis, this study found publication trends, prolific journals, influential articles, and major themes in the field, whereas the TCM framework helped identify widely used theories (motivation theory, immigration theory, acculturation theory, learning theory, and capital theory), research contexts (destination country or region, population, and others), and methods in research and provided future study directions. The identified gaps in the existing literature suggest that future research should develop theoretical foundations and research designs to analyse new processes, patterns, and issues in ISM in higher education within the context of today's changing international environment. In addition to identifying the key research themes and research foundations of ISM in higher education, this review can help add value to the ISM literature from a marketing perspective. This is the first comprehensive literature review of this topic using a hybrid approach.
Multiple, speeded assessments: Initial evidence on subgroup differences and applicant perceptions
Authors: Lievens Filip , Corstjens Jan , Herde Christoph N. 
Published: February 2023

AbstractRecently, shorter assessments have emerged as potential alternatives for more resourceful traditional selection approaches. Multiple, speeded assessments (MSAs) represent such an alternative. In MSAs, candidates participate in a large number of short (a maximum of 5 min), behavioral simulations in which they face a variety of job situations. Initial psychometric evidence on the validity of MSAs is promising. Yet, validity represents only one piece of evidence. It is not known whether MSAs disadvantage specific subgroups, which may inhibit diversity. There is also no information on candidates' experience of going through an MSA, which is pivotal for the attractiveness of the organization's selection process. Therefore, this study investigates an MSA in terms of subgroup differences (gender and nationality) and applicant perceptions. Master of Business Administration (MBA) students (N = 96) proceeded through 18 short role‐plays sampling junior management situations. Score differences between men and women were negligible. Yet, there were large score differences between national citizens and foreigners. There was no evidence for predictive bias for nationality, though. Of the applicant reaction measures, interpersonal treatment perceptions contributed most to overall fairness perceptions. These findings add to the evidence in support of MSAs, while also stressing to remain vigilant for potential score differences among subgroups.
RETRACTED: Haemoglobin changes before and after packed red blood cells transfusion in burn patients: A retrospective cross‐sectional study
Authors: Parvizi Arman , Haddadi Soudabeh , Atrkar Roshan Zahra , Kafash Pardis 
Published: February 2023

AbstractThe present study aimed to investigate haemoglobin (Hb) changes before and after packed red blood cell (RBC) transfusion in burn patients. This study was a retrospective cross‐sectional study that was conducted on burn patients in Velayat hospital in Rasht, Iran. The sampling method of this study was consecutive sampling. Data were collected using patient records, including age, gender, body mass index (BMI), total body surface area (TBSA) percentage, length of hospitalisation, Frequency of receiving packed RBCs, and Hb level before each packed RBC transfusion and 4 to 6 hours after transfusion. Paired t tests and analysis of variance (ANOVA) were used to compare the study variables. Pearson's correlation coefficient was used to investigate the relationship between Hb changes after the transfusion of packed RBCs and the study variables. A total of 110 burn patients participated in this study. The average Hb before and after transfusion was 8.07 (SD = 0.97) and 9.16 (SD = 1.01), respectively, which were significantly different (P = .0001). The results showed that there was a significant negative relationship between the variables of age (r = −0.188, P = .0001), BMI (r = −0.110, P = .035), and TBSA percentage (r = −0.122, P = .019) with changes in Hb after transfusion. Also, the duration of hospitalisation had a significant positive relationship with Hb changes after transfusion (r = 0.124, P = .017). In sum, Hb level compensation through packed RBC transfusion in elderly burn patients has more challenges. The number of changes in Hb level after receiving packed RBCs decreased with increasing TBSA, BMI, and age. Also, there was a positive correlation between the duration of hospitalisation and changes in Hb levels.
Analysis of the genomic landscape of inbreeding in two divergent groups of Spanish Florida goats
Authors: Ziegler Tatiana E. , Molina Antonio , Ramón Manuel , Sanchez Manuel , Muñoz‐Mejías Eva , Antonini Alicia , Demyda‐Peyrás Sebastián 
Published: February 2023

AbstractThe analysis of the genomic landscape of inbreeding using runs of homozygosity (ROH) patterns is becoming an interesting tool to partially understand phenotypic differences among individuals. In this study, we analysed genome‐wide ROH patterns in two groups of Florida goats. We first determined the inbreeding levels of each individual by calculating ROH‐based inbreeding coefficients (FROH). Then, the individuals were divided into two groups based onFROH: high inbreeding (HI,FROH >0.1) and low inbreeding (LI,FROH <0.03). Finally, we performed an extensive in‐depth analysis of ROH distribution in each group separately. We found a higher abundance of short ROH in LI, whereas long ROH was more frequent in HI. Furthermore, ROH abundance was not evenly distributed among chromosomes within groups, with some chromosomes showing larger numbers of ROH, like CHI6, CHI7 and CHI27. A different landscape was observed in recent inbreeding (ROH >8 Mb), with significant increases in CHI6, CHI11 and CHI28. Determination of genomic regions with significantly increased ROH (ROH islands—ROHi) showed 13 ROHi related to whole inbreeding and five ROHi associated with recent inbreeding analysis. Within these genomic regions, 123 and 101 genes were identified in HI and LI, respectively, including 10 and seven candidate genes previously related to production, fertility and heat resistance in goats and livestock species.
Individual, interpersonal and environmental correlates of sedentary behaviours in adults with intellectual disabilities
Authors: Chusamer K. , Melville C. A. , McGarty A. M. 
Published: February 2023

AbstractBackgroundSedentary behaviours have adverse health outcomes and adults with intellectual disabilities are at a higher risk of unhealthy lifestyle behaviours. The lack of knowledge relating to sedentary behaviours in adults with intellectual disabilities has impeded the development of effective interventions. This study aimed to investigate individual, interpersonal and environmental correlates that are associated with sedentary behaviours in adults with intellectual disabilities.MethodA secondary analysis of data from The UK Household Longitudinal Study (Understanding Society; collected 2011–2013) was conducted. Twenty‐two predictor variables were included in a stepwise logistic regression, with TV hours during weekdays (≤3 and >3 h/day) used as a proxy for sedentary behaviours. A sample of 266 adults, with mean age of 37.9 and range from 18 to 49 years old, with intellectual disabilities were identified. Because 63.9% were female, 62.4% had children and 28.2% were employed, the sample is likely to be most representative of more able adults with intellectual disabilities.ResultsA significant interaction term between having children and neighbourhood status was found in the initial model so separate models for good and poor‐quality neighbourhoods are reported. Having children only had a significant effect to lower the odds of high TV time among participants living in good quality neighbourhoods (OR 0.10, 95% CI 0.03, 0.25). However, for people living in poor quality neighbourhoods it was better quality leisure services that was associated with lower odds of high TV time (OR 0.48, 95% CI 0.23, 0.90). Being employed only significantly reduced the odds of high TV time in the good quality neighbourhood model (OR 0.35, 95% CI 0.12, 0.78). These effects highlight the importance of environmental effects on lifestyle behaviours of adults with intellectual disabilities.ConclusionsFuture research should aim to expand our understanding of environmental effects on the sedentary behaviours and other lifestyle behaviours of adults with intellectual disabilities.
International Housing Markets and the U.S. Subprime Crisis
Authors: LUO SHIKONG (SCOTT) , MA JUN 
Published: February 2023

AbstractWe propose a novel decomposition approach to study the degree of co‐movement of international housing markets while distinguishing among different economic drivers. We find that the housing market variability for an average country was mainly driven by the common housing risk premium components during the years leading up to the 2007–08 subprime financial crisis. A decrease in the common housing risk premium was followed by a housing boom and economic expansion in the United States prior to the crisis. Our findings add to the understanding of the role of common risk factors across international housing markets before the crisis.