bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between nation and empire: how the state matters in global health
Authors: Harrington John 
Published: January 2023

AbstractThe role of the state has been underplayed in scholarship on global health. Taking a historical view, this paper argues that state institutions, practices and ideologies have in fact been crucial to the realisation of contemporary global health governance and to its predecessor regimes. Drawing on state theory, work on governmentality, and Third World approaches to international law, it traces the origins of the ‘health state’ in late colonial developmentalism, which held out the prospect of conditional independence for the subjects of European empires. Progress in health was also a key goal for nationalist governments in the Global South, one which they sought to realise autonomously as part of a New International Economic Order. The defeat of that challenge to the dominance of the Global North in the 1980s led to the rise of ‘global governance’ in health. Far from rendering the state redundant, the latter was realised through the co-option and disciplining of institutions at national level. To that extent, the current order has an unmistakably imperial character, one which undercuts its declared cosmopolitan aspirations, as evidenced in the approach to vaccine distribution and travel bans during the Covid-19 pandemic.
A non-marine horseshoe crab from the Middle Triassic (Anisian) of the Netherlands
Authors: Klompmaker Adiël A. , van Eldijk Timo J.B. , Winkelhorst Herman , Reumer Jelle W.F. 
Published: January 2023

Abstract
Horseshoe crabs (Xiphosura) have a long evolutionary history starting in the Ordovician, but they have rarely been reported from the Netherlands. We report on the first Triassic horseshoe crab from the Netherlands identifiable to the species level, a specimen of the limulid Limulitella bronnii. We provide the first diagnosis for this species and refigure the holotype. The new specimen was found in the Middle Triassic (Anisian) Muschelkalk sediments of the Vossenveld Formation, in the Illyrian part of the stratigraphic profile of the Winterswijk quarry complex. The Winterswijk specimen represents the youngest occurrence of L. bronnii. The inferred non-marine habitat of this horseshoe crab species elsewhere in conjunction with occurrences of plant and insect remains within the same layer at Winterswijk suggest the specimen herein most probably did not live in marine conditions either. This species has previously been found in non-marine sediments in France and Germany, expanding its geographic range northward. Several faunal elements from Winterswijk including L. bronnii show resemblance to the roughly co-eval non-marine components of the Anisian Grès à Voltzia Formation in NE France, suggesting a paleobiogeographic connection between these regions in Western Europe.
Exploring human biology with N-of-1 clinical trials
Authors: Schork N. J. , Beaulieu-Jones B. , Liang W. S. , Smalley S. , Goetz L. H. 
Published: January 2023

Abstract
Studies on humans that exploit contemporary data-intensive, high-throughput ‘omic’ assay technologies, such as genomics, transcriptomics, proteomics and metabolomics, have unequivocally revealed that humans differ greatly at the molecular level. These differences, which are compounded by each individual’s distinct behavioral and environmental exposures, impact individual responses to health interventions such as diet and drugs. Questions about the best way to tailor health interventions to individuals based on their nuanced genomic, physiologic, behavioral, etc. profiles have motivated the current emphasis on ‘precision’ medicine. This review’s purpose is to describe how the design and execution of N-of-1 (or personalized) multivariate clinical trials can advance the field. Such trials focus on individual responses to health interventions from a whole-person perspective, leverage emerging health monitoring technologies, and can be used to address the most relevant questions in the precision medicine era. This includes how to validate biomarkers that may indicate appropriate activity of an intervention as well as how to identify likely beneficial interventions for an individual. We also argue that multivariate N-of-1 and aggregated N-of-1 trials are ideal vehicles for advancing biomedical and translational science in the precision medicine era since the insights gained from them can not only shed light on how to treat or prevent diseases generally, but also provide insight into how to provide real-time care to the very individuals who are seeking attention for their health concerns in the first place.
Rethinking adoptionism: An argument for dismantling a dubious category
Authors: Coogan Jeremiah 
Published: January 2023

AbstractThis article argues that adoptionism is an anachronistic category when used to describe texts from the first three Christian centuries, a mirage created by later theological controversies about the relationship between the Father and the Son. I survey the evidence for second- and third-century figures and texts generally identified ‘adoptionist’ in order to show that these figures do not advocate a shared christological stance. Instead, we find a variety of distinct postures that disagree with both each other and with common scholarly definitions of adoptionism. Although metaphors of adoption were theologically productive in early Christianity, to identify early Christian figures, texts and movements as adoptionist implies a theological unity that does not exist. The category itself is a problem. Not only are historical adoptionists absent, but early Christian metaphors of adoption and divine sonship functioned within diverse articulations of Jesus’ identity which do not map onto modern definitions.
Exercise testing in patients with multisystem inflammatory syndrome in children-related myocarditis versus idiopathic or viral myocarditis
Authors: Ziebell Daniel , Patel Trisha , Stark Megan , Xiang Yijin , Oster Matthew E. 
Published: January 2023

AbstractBackground:While most children with multisystem inflammatory syndrome in children have rapid recovery of cardiac dysfunction, little is known about the long-term outcomes regarding exercise capacity. We aimed to compare the exercise capacity among patients with multisystem inflammatory syndrome in children versus viral/idiopathic myocarditis at 3–6 months after initial diagnosis.Methods:We performed a retrospective cohort study among patients with multisystem inflammatory syndrome in children in June 2020 to May 2021 and patients with viral/idiopathic myocarditis in August 2014 to January 2020. Data from cardiopulmonary exercise test as well as echocardiographic and laboratory data were obtained. Inclusion criteria included diagnosis of multisystem inflammatory syndrome in children or viral/idiopathic myocarditis, exercise test performed within 3–6 months of hospital discharge, and maximal effort on cardiopulmonary exercise test as determined by respiratory exchange ratio >1.10.Results:Thirty-one patients with multisystem inflammatory syndrome in children and 25 with viral/idiopathic myocarditis were included. The mean percent predicted peak VO2 was 90.84% for multisystem inflammatory syndrome in children patients and 91.08% for those with viral/idiopathic myocarditis (p-value 0.955). There were no statistically significant differences between the groups with regard to percent predicted maximal heart rate, metabolic equivalents, percent predicted peak VO2, percent predicted anerobic threshold, or percent predicted O2 pulse. There was a statistically significant correlation between lowest ejection fraction during hospitalisation and peak VO2 among viral/idiopathic myocarditis patients (r: 0.62, p-value 0.01) but not multisystem inflammatory syndrome in children patients (r: 0.1, p-value 0.6).Conclusions:Patients with multisystem inflammatory syndrome in children and viral myocarditis appear to, on average, have normal exercise capacity around 3–6 months following hospital discharge. For patients with viral/idiopathic myocarditis, those with worse ejection fraction during hospitalisation had lower peak VO2 on cardiopulmonary exercise test.
Simulation of Chorus Wave Excitation in the Compressed/Stretched Dipole Magnetic Field
Authors: Kong Zhenyu , Gao Xinliang , Ke Yangguang , Lu Quanming , Wang Xueyi 
Published: January 2023

AbstractThe properties of chorus waves have been extensively studied, which are important to understand chorus generation and wave‐particle interactions between chorus and energetic electrons. Observations reveal that there exists a distinct day‐night asymmetry for the properties of chorus waves, such as the sweep rate and duration, which is predicted to be relevant to the asymmetric configuration of Earth's background magnetic field. In this paper, using the one‐dimensional (1‐D) particle‐in‐cell (PIC) simulation model with a compressed/stretched dipole magnetic field, we study the dependences of the properties of rising‐tone chorus waves on the background magnetic field. It is demonstrated that the saturated amplitude and the chorus sweep rate increase while the chorus duration decreases with an increase of the compression factor ξ, which represents the compression/stretch degree of the field line. Moreover, the threshold of exciting chorus waves in the compressed dipole field is generally lower than that in the stretched dipole field. These results are useful to understand the chorus excitation and the day‐night asymmetry of chorus properties.
Revisit the Upper Portion of the Japan Sea Proper Water: A Recent Structural Change and Freshening in the Formation Area
Authors: Senjyu Tomoharu , Shiota Kohei 
Published: January 2023

AbstractLong‐term transition in the deep water of the Japan Sea was investigated to understand how oceans respond to climate change. A basin‐scale density decrease in the upper portion of the Japan Sea Proper Water (UJSPW) by 0.01 σθ was detected from the period 1964–1985 (Period I) to that of 2001–2019 (Period II) using Argo‐ and ship‐based data sets. The density decrease was mainly due to a temperature increase of 0.3°C. Based on the pycnostad density, the UJSPW was redefined as the water mass of 27.30–27.33 σθ, along with the core density of 27.30–27.31 σθ. The dissolved oxygen (DO) and thickness in the UJSPW showed a notable decrease between the periods, along with the isopycnal surfaces flattening. Warming down to 700 m and freshening in the upper 300 m were observed in the winter UJSPW formation area in the northwestern Japan Sea. An influence of the hemispheric‐scale regime shift occurred in 1988/1989 on the UJSPW warming was suggested, along with the long‐term trend in the winter air temperature. The freshening in the formation area was attributable to the increase in winter precipitation in the Amur River basin and the decrease in winter sea‐ice extents in the Okhotsk and northern Japan Seas. The intensified stratification in the UJSPW formation area brought a decrease in the amount of the UJSPW formation through the prevention of winter deep convection, which resulted in the thinner thickness and lower DO in the UJSPW in Period II, along with the temperature increase.
Global Sea Surface Cyclogeostrophic Currents Derived From Satellite Altimetry Data
Authors: Cao Yuhan , Dong Changming , Stegner Alexandre , Bethel Brandon J. , Li Chunyan , Dong Jihai , Lü Haibin , Yang Jingsong 
Published: January 2023

AbstractSea surface currents (SSC) derived from the sea surface height anomalies (SSHA) as measured by multi‐satellite altimeters are widely used for various applications including studies on ocean dynamics, marine ecology, and climate change. However, present SSC products estimated on the assumption of an idealized geostrophic balance is biased. To overcome this idealization, this study considers flow curvature in the estimation of sea surface velocities in the global ocean, with the computation scheme validated using numerical model results. It is demonstrated that the inclusion of curvature into SSC estimations significantly changes SSC dynamic features in terms of kinetic energy, enstrophy (the maximum spatial difference is about 15%), and strain rate (the maximum spatial difference is about 10%). Such correction is of importance to the application studies relying on the SSC products from the satellite measured SSHA.
Characterizing Average Seasonal, Synoptic, and Finer Variability in Orbiting Carbon Observatory‐2 XCO2 Across North America and Adjacent Ocean Basins
Authors: Mitchell Kayla A. , Doney Scott C. , Keppel‐Aleks Gretchen 
Published: January 2023

AbstractVariations in atmosphere total column‐mean CO2 (XCO2) collected by the National Aeronautics and Space Administration's Orbiting Carbon Observatory‐2 satellite can be used to constrain surface carbon fluxes if the influence of atmospheric transport and observation errors on the data is known and accounted for. Due to sparse validation data, the portions of fine‐scale variability in XCO2 driven by fluxes, transport, or retrieval errors remain uncertain, particularly over the ocean. To better understand these drivers, we characterize variability in OCO‐2 Level 2 version 10 XCO2 from the seasonal scale, synoptic‐scale (order of days, thousands of kilometers), and mesoscale (within‐day, hundreds of kilometers) for 10 biomes over North America and adjacent ocean basins. Seasonal and synoptic variations in XCO2 reflect real geophysical drivers (transport and fluxes), following large‐scale atmospheric circulation and the north‐south distribution of biosphere carbon uptake. In contrast, geostatistical analysis of mesoscale and finer variability shows that real signals are obscured by systematic biases across the domain. Spatial correlations in along‐track XCO2 are much shorter and spatially coherent variability is much larger in magnitude than can be attributed to fluxes or transport. We characterize random and coherent along‐track XCO2 variability in addition to quantifying uncertainty in XCO2 aggregates across typical lengths used in inverse modeling. Even over the ocean, correlated errors decrease the independence and increase uncertainty in XCO2. We discuss the utility of computing geostatistical parameters and demonstrate their importance for XCO2 science applications spanning from data reprocessing and algorithm development to error estimation and carbon flux inference.
The Roles of Surface Convergence Line and Upper‐Level Forcing on Convection Initiation Ahead of a Gust Front: A Case Study
Authors: Cui Xinyan , Chen Mingxuan , Qin Rui , Li Chun , Han Lei 
Published: January 2023

AbstractUsing observation data and the simulations of Variational Doppler Radar Analysis System (VDRAS), the convection initiation (CI) ahead of a gust front over the Yangtze River Delta in Jiangsu province, China on 5 June 2009 was studied. The CI was located in the exit region of the upper level jet with moderate CAPE. It is found that, there was a northeast‐southwest convergence line near the ground ahead of the gust front, which could not trigger the new convection alone. The upper‐level updraft above the surface convergence line could not trigger the new convection alone either. The superposition of the updraft in the upper and low levels promoted the initiation and development of the new convective cell. Finally, the new convective cell developed continuously to the southwest and southeast, and extended to the southeast under the influence of the upper‐level wind. And the sensitivity experiments show that the surface convergence line and the upper‐level convergence were both important for the CI, especially for the strong convection. This discrete CI ahead of the gust front was influenced by a combination of low‐level and upper‐level factors. In the process of the CI, the updraft in the upper level intensified faster than that in the low level gradually. The buoyancy force was greater than the vertical perturbation pressure gradient force (VPPGF) in the low level, while the VPPGF increased faster than buoyancy in the upper level. Therefore, the dynamics of the updraft in the low and upper levels were different.
Computation of Optical Refractive Index Structure Parameter From Its Statistical Definition Using Radiosonde Data
Authors: Quatresooz Florian , Vanhoenacker‐Janvier Danielle , Oestges Claude 
Published: January 2023

AbstractKnowledge of the optical refractive index structure parameteris of interest for Free Space Optics and ground‐based optical astronomy, as it depicts the strength of the expected scintillation on the received optical waves. Focus is given here to models using meteorological quantities coming from radiosonde measurements as inputs to estimate theprofile in the atmosphere. A model relying on thestatistical definition is presented and applied to recent high‐density radiosonde profiles at Trappes (France) and Hilo, HI (USA). It is also compared to thermosonde measurements coming from the T‐REX campaign. This model enables to obtain site‐specific average profiles and to identify isolated turbulent layers using only pressure and temperature measurements, paving the way for optical site selection. It offers similar performance when compared to a Tatarskii‐based model inspired by the literature.
Rhizobial migration toward roots mediated by FadL-ExoFQP modulation of extracellular long-chain AHLs
Authors: Ji Yuan-Yuan , Zhang Biliang , Zhang Pan , Chen Liu-Chi , Si You-Wei , Wan Xi-Yao , Li Can , Wang Ren-He , Tian Yu , Zhang Ziding , Tian Chang-Fu 
Published: January 2023

Abstract
Migration from rhizosphere to rhizoplane is a key selecting process in root microbiome assembly, but not fully understood. Rhizobiales members are overrepresented in the core root microbiome of terrestrial plants, and here we report a genome-wide transposon-sequencing of rhizoplane fitness genes of beneficial Sinorhizobium fredii on wild soybean, cultivated soybean, rice, and maize. There were few genes involved in broad-host-range rhizoplane colonization. The fadL mutant lacking a fatty acid transporter exhibited high colonization rates, while mutations in exoFQP (encoding membrane proteins directing exopolysaccharide polymerization and secretion), but not those in exo genes essential for exopolysaccharide biosynthesis, led to severely impaired colonization rates. This variation was not explainable by their rhizosphere and rhizoplane survivability, and associated biofilm and exopolysaccharide production, but consistent with their migration ability toward rhizoplane, and associated surface motility and the mixture of quorum-sensing AHLs (N-acylated-L-homoserine lactones). Genetics and physiology evidences suggested that FadL mediated long-chain AHL uptake while ExoF mediated the secretion of short-chain AHLs which negatively affected long-chain AHL biosynthesis. The fadL and exoF mutants had elevated and depleted extracellular long-chain AHLs, respectively. A synthetic mixture of long-chain AHLs mimicking that of the fadL mutant can improve rhizobial surface motility. When this AHL mixture was spotted into rhizosphere, the migration toward roots and rhizoplane colonization of S. fredii were enhanced in a diffusible way. This work adds novel parts managing extracellular AHLs, which modulate bacterial migration toward rhizoplane. The FadL-ExoFQP system is conserved in Alphaproteobacteria and may shape the “home life” of diverse keystone rhizobacteria.
Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria
Authors: Xie Xiao-Qing , Yang Yi , Wang Qiang , Liu Hao-Fei , Fang Xuan-Yu , Li Cheng-Long , Jiang Yi-Zhou , Wang Shuai , Zhao Hong-Yu , Miao Jing-Ya , Ding Shuai-Shuai , Liu Xin-Dong , Yao Xiao-Hong , Yang Wen-Tao , Jiang Jun , Shao Zhi-Ming , Jin Guoxiang , Bian Xiu-Wu 
Published: January 2023

AbstractOnly a small proportion of patients with triple-negative breast cancer benefit from immune checkpoint inhibitor (ICI) targeting PD-1/PD-L1 signaling in combination with chemotherapy. Here, we discovered that therapeutic response to ICI plus paclitaxel was associated with subcellular redistribution of PD-L1. In our immunotherapy cohort of ICI in combination with nab-paclitaxel, tumor samples from responders showed significant distribution of PD-L1 at mitochondria, while non-responders showed increased accumulation of PD-L1 on tumor cell membrane instead of mitochondria. Our results also revealed that the distribution pattern of PD-L1 was regulated by an ATAD3A-PINK1 axis. Mechanistically, PINK1 recruited PD-L1 to mitochondria for degradation via a mitophagy pathway. Importantly, paclitaxel increased ATAD3A expression to disrupt proteostasis of PD-L1 by restraining PINK1-dependent mitophagy. Clinically, patients with tumors exhibiting high expression of ATAD3A detected before the treatment with ICI in combination with paclitaxel had markedly shorter progression-free survival compared with those with ATAD3A-low tumors. Preclinical results further demonstrated that targeting ATAD3A reset a favorable antitumor immune microenvironment and increased the efficacy of combination therapy of ICI plus paclitaxel. In summary, our results indicate that ATAD3A serves not only as a resistant factor for the combination therapy of ICI plus paclitaxel through preventing PD-L1 mitochondrial distribution, but also as a promising target for increasing the therapeutic responses to chemoimmunotherapy.
Mental health support across the sight loss pathway: a qualitative exploration of eye care patients, optometrists, and ECLOs
Authors: Trott M. , Driscoll R. , Bourne R. , Slade J. , Ingleton H. , Farrell S. , Bowen M. , Lovell-Patel R. , Kidd J. , Pardhan S. 
Published: January 2023

Abstract
Background
The process of becoming visually impaired or blind is undoubtedly a highly emotional experience, requiring practical and psychological support. Information on mental health support provision in the UK across the sight-loss pathway, however, is largely unknown, especially amongst healthcare practitioners that are often sought after for advice: the referring optometrist and eye clinic liaison officer (ECLO). This study aims to ascertain the perceived accessibility and quality of mental health support across the sight-loss pathway.

Methods
Semi-structured individual interviews were conducted with patients with a diagnosed eye condition who had received care from a hospital eye service, referring optometrists, and ECLOs. Following interview transcription, results were synthesised in a narrative analysis.

Results
A total of 28 participants were included in the analysis, of which 17 were participants with various eye conditions, five were referring optometrists, and five were ECLOs. After analysis, three broad themes emerged: (1) The emotional trauma of diagnosis (2) Availability of mental health support; (3) The point where mental health support is most needed across the sight-loss pathway. Several patients reporting that they had received no offer of support nor were they signposted to any possible sources. Referring optometrists and ECLO’s agreed.

Conclusion
It is important that referring optometrists are aware of the need for mental health support services and can signpost to local support services including the third sector anytime during the referral process. Future large-scale, UK-wide research into referral practice and signposting for mental health support for patients is warranted, to identify how services can be improved in order to ensure that the wellbeing of patients is maintained.