bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Soybean Waste Ash as Additional Ingredients Against the Compression Strenght of Concrete
Authors: Kustirini Anik , Budiningrum Diah Setyati , Purnijanto Bambang , Amanuyasa Yuda , Aji Juniarto Bayu 
Published: May 2023

Abstract
Concrete is an element that is needed in various kinds of civil engineering building construction. This research aims to investigate the effect of adding soybean waste ash on the compressive strength of concrete. Soybean waste ash content used in manufacturing concrete samples was 0%, 3%, 6%, and 9%. The planned compressive strength is 20 MPa. In this study, 9 samples of each test object were made with a cylindrical mold size of 15cm X 30cm. The compressive strength test was carried out when the concrete was 7 days, 14 days, and 28 days. It was concluded that the concrete with the added material of soybean waste ash increased in each test age. The maximum concrete compressive strength occurs at 28 days with 6% soybean waste ash content, with concrete compressive strength of 27.30 MPa.
Feed Durability and Feed Quality of Concentrate Feed with Addition of Monosodium Glutamate Manufacturing by-products
Authors: Aprilliza M N , Krishna N H , Mariyono  , Pamungkas D 
Published: May 2023

Abstract
This research was conducted at the Nutrition and Animal Feed Laboratory, Beef Cattle Research Institute, Grati, Pasuruan, East Java. This study aimed to determine the effect of the addition of MSG by-product on the durability and nutritional content of the concentrate. The material used in this research was concentrate, which contained several raw materials and was added with MSG by-product with several levels. The treatments applied were: Treatment A: 5 Kg Concentrate (C) + 12% MSG by product (OP); Treatment B: C + 16% OP; Treatment C: C + 20% OP; and Treatment D: C + 24% OP. Observations on variables were carried out for 4 weeks, and the data obtained were analyzed descriptively. The results showed that until the fourth week of storage, there were no differences in flavor, clumpiness, louse, and fungus in treatments A, B, C, and D. In the color of the concentrate, it was known that treatment D had a brownish color but was the darkest when compared to the other treatments and the dust produced by treatment A appears to have the highest dust. However, it was found that the total acid content in treatment D has the highest total acid content, as a result of adding the highest OP concentration and resulting in the highest total acid formation when fermentation occurs during the feed shelf life. Based on these data, it can be concluded that adding OP to the concentrate could maintain its durability and quality until the fourth week of storage in the feed warehouse.
Internally crosslinked alginate-based bioinks for the fabrication of in vitro hepatic tissue models
Authors: Guagliano Giuseppe , Volpini Cristina , Camilletti Jacopo , Donnaloja Francesca , Briatico-Vangosa Francesco , Visai Livia , Petrini Paola 
Published: May 2023

Abstract
Bioprinting is a key technique to fabricate cell-laden volumetric constructs with controlled geometry. It can be used not only to replicate the architecture of a target organ but also to produce shapes that allow for the mimicry, in vitro, of specific desired features. Among the various materials suitable to be processed with this technique, sodium alginate is currently considered one of the most appealing because of its versatility. To date, the most widespread strategies to print alginate-based bioinks exploit external gelation as a primary process, by directly extruding the hydrogel-precursor solution into a crosslinking bath or within a sacrificial crosslinking hydrogel, where the gelation takes place. In this work, we describe the print optimization and the processing of Hep3Gel: an internally crosslinked alginate and ECM-based bioink for the production of volumetric hepatic tissue models. We adopted an unconventional strategy, by moving from the reproduction of the geometry and the architecture of liver tissue to the use of bioprinting to fabricate structures that can promote a high degree of oxygenation, as is the case with hepatic tissue. To this end, the design of structures was optimized by employing computational methods. The printability of the bioink was then studied and optimized through a combination of different a priori and a posteriori analyses. We produced 14-layered constructs, thus highlighting the possibility to exploit internal gelation alone to directly print self-standing structures with finely controlled viscoelastic properties. Constructs loaded with HepG2 cells were successfully printed and cultured in static conditions for up to 12 d, underlining the suitability of Hep3Gel to support mid/long-term cultures.
Closed corner divertor with B × ∇B away from the divertor: a promising divertor scenario for tokamak power exhaust
Authors: XU Guosheng , JIA Guozhang , DING Genfan , TAO Yuqiang , MENG Lingyi , YU Lin , WANG Liang , LIU Jianbin 
Published: May 2023

Abstract
A major challenge facing the steady-state operation of tokamak fusion reactors is to develop a viable divertor solution with order-of-magnitude increase in power handling capability as compared with present experience. A recently developed divertor concept for this end has been tested recently on EAST tokamak through combining the effects of a closed divertor corner and
E ×
B
drifts. The
E ×
B
drifts in the divertor move particles towards the outer divertor corner area in the scrape-off layer for
B
× ∇B directed away from the divertor, which can significantly enhance the particle concentration there, facilitating divertor detachment. In recent EAST experiments, the effects have been demonstrated where the lowest electron temperature at the divertor plate is obtained with strike point located close to the corner in the horizontal target and with
B
× ∇B away from the divertor. These experimental results are in reasonable agreement with SOLPS-ITER simulations including drift effects, suggesting that the new divertor concept potentially provides a promising divertor solution for long-pulse operations of future tokamak fusion reactors with much higher power fluxes.
Preparation and performance optimization of resistive flexible temperature sensors prepared by inkjet printing method
Authors: Wang Shuilian , Hu Yuxuan , Ma Lisha , Cui Xiaoqing , Peng Yuan , Zheng Jiahui , Qiao Lu , Ma Haitao , Wang Rui , Zhang Hongyan 
Published: May 2023

Abstract
In recent years, inkjet printing has been widely used in the field of flexible sensor preparation. However, the effects of inkjet printing parameters and post-processing conditions on sensor performance have not been systematically investigated. Simple fabrication and optimized performance are eagerly desired for the practical use of temperature sensors in wearable healthcare devices. Herein, we report the resistive flexible temperature sensor fabricated on polyethylene terephthalate (PET) substrates with silver nanoparticles (AgNPs)-based ink using an inkjet printer. We have thoroughly investigated and optimized the sensitivity and linearity between the resistance and temperature of inkjet-printed temperature sensors by adjusting droplet spacing and curing conditions (temperature and time). In conclusion, the droplet spacing of 20 µm and the curing condition of 30 min at 150 °C were determined as the optimized parameters. With optimized process parameters, the temperature sensor has a high sensitivity of 0.084 °C−1 and a linear coefficient of 0.999 between relative resistance and temperature in the range of 30 °C–100 °C. Furthermore, it has a fast response time (7 s) and high stability against repeated bending deformation of 500 cycles. The prepared wearable sensors have potential application prospects in temperature monitoring.
VI—On Type Distinctions and Expressivity
Authors: Florio Salvatore 
Published: May 2023

AbstractQuine maintained that philosophical and scientific theorizing should be conducted in an untyped language, which has just one style of variables and quantifiers. By contrast, typed languages, such as those advocated by Frege and Russell, include multiple styles of variables and matching kinds of quantification. Which form should our theories take? In this article, I argue that expressivity does not favour typed languages over untyped ones.
Nightingale: web components for protein feature visualization
Authors: Salazar Gustavo A , Luciani Aurélien , Watkins Xavier , Kandasaamy Swaathi , Rice Daniel L , Blum Matthias , Bateman Alex , Martin Maria 
Published: May 2023

Abstract

Motivation
The visualization of biological data is a fundamental technique that enables researchers to understand and explain biology. Some of these visualizations have become iconic, for instance: tree views for taxonomy, cartoon rendering of 3D protein structures or tracks to represent features in a gene or protein, for instance in a genome browser. Nightingale provides visualizations in the context of proteins and protein features.

Results
Nightingale is a library of re-usable data visualization web components that are currently used by UniProt and InterPro, among other projects. The components can be used to display protein sequence features, variants, interaction data, 3D structure, etc. These components are flexible, allowing users to easily view multiple data sources within the same context, as well as compose these components to create a customized view.

Availability and implementation
Nightingale examples and documentation are freely available at https://ebi-webcomponents.github.io/nightingale/. It is distributed under the MIT license, and its source code can be found at https://github.com/ebi-webcomponents/nightingale.
FLONE: fully Lorentz network embedding for inferring novel drug targets
Authors: Yue Yang , McDonald David , Hao Luoying , Lei Huangshu , Butler Mark S , He Shan 
Published: May 2023

Abstract

Motivation
To predict drug targets, graph-based machine-learning methods have been widely used to capture the relationships between drug, target and disease entities in drug–disease–target (DDT) networks. However, many methods cannot explicitly consider disease types at inference time and so will predict the same target for a given drug under any disease condition. Meanwhile, DDT networks are usually organized hierarchically carrying interactive relationships between involved entities, but these methods, especially those based on Euclidean embedding cannot fully utilize such topological information, which might lead to sub-optimal results. We hypothesized that, by importing hyperbolic embedding specifically for modeling hierarchical DDT networks, graph-based algorithms could better capture relationships between aforementioned entities, which ultimately improves target prediction performance.

Results
We formulated the target prediction problem as a knowledge graph completion task explicitly considering disease types. We proposed FLONE, a hyperbolic embedding-based method based on capturing hierarchical topological information in DDT networks. The experimental results on two DDT networks showed that by introducing hyperbolic space, FLONE generates more accurate target predictions than its Euclidean counterparts, which supports our hypothesis. We also devised hyperbolic encoders to fuse external domain knowledge, to make FLONE enable handling samples corresponding to previously unseen drugs and targets for more practical scenarios.

Availability and implementation
Source code and dataset information are at: https://github.com/arantir123/DDT_triple_prediction.

Supplementary information
Supplementary data are available at Bioinformatics Advances online.
Molecular basis of FAAH-OUT-associated human pain insensitivity
Authors: Mikaeili Hajar , Habib Abdella M , Yeung Charlix Wai-Lok , Santana-Varela Sonia , Luiz Ana P , Panteleeva Kseniia , Zuberi Sana , Athanasiou-Fragkouli Alkyoni , Houlden Henry , Wood John N , Okorokov Andrei L , Cox James J 
Published: May 2023

Abstract
Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain insensitivity disorders. Here we report how the recently discovered brain and dorsal root ganglia-expressed FAAH-OUT long non-coding RNA (lncRNA) gene, which was found from studying a pain-insensitive patient with reduced anxiety and fast wound healing, regulates the adjacent key endocannabinoid system gene FAAH, which encodes the anandamide-degrading fatty acid amide hydrolase enzyme.
We demonstrate that the disruption in FAAH-OUT lncRNA transcription leads to DNMT1-dependent DNA methylation within the FAAH promoter. In addition, FAAH-OUT contains a conserved regulatory element, FAAH-AMP, that acts as an enhancer for FAAH expression.
Furthermore, using transcriptomic analyses in patient-derived cells we have uncovered a network of genes that are dysregulated from disruption of the FAAH-FAAH-OUT axis, thus providing a coherent mechanistic basis to understand the human phenotype observed.
Given that FAAH is a potential target for the treatment of pain, anxiety, depression and other neurological disorders, this new understanding of the regulatory role of the FAAH-OUT gene provides a platform for the development of future gene and small molecule therapies.
Health Care in Service of Life: Preventative Medicine in Light of the Analogia Entis
Authors: Hirschfeld Mary 
Published: May 2023

Abstract
The medicalization of risk rests on foundational assumptions shared by economics and public health. Economists, however, think in terms of pursuing an array of goods, and hence, they offer useful critiques of the irrationality involved in trying to subordinate all goods to one narrow good, like avoiding death from a particular disease. Many of our approaches to health do not appear to be fully rational, suggesting that the deeper motivation lying behind our concerns about health are to be found in something other than the impulse to extend human lives as much as possible. This paper draws on the theology of St. Thomas Aquinas to sketch a richer way of thinking about the goods we pursue in health care that can help us to avoid the pitfalls associated with the medicalization of risk.
Evaluation of advanced imaging biomarkers at kidney failure in patients with ADPKD: a pilot study
Authors: Wigerinck Stijn , Gregory Adriana V , Smith Byron H , Iliuta Ioan-Andrei , Hanna Christian , Chedid Maroun , Kaidbay Hasan-Daniel N , Senum Sarah R , Shukoor Shebaz , Harris Peter C , Torres Vicente E , Kline Timothy L , Chebib Fouad T 
Published: May 2023

ABSTRACT

Background
Autosomal dominant polycystic kidney disease (ADPKD) presents with variable disease severity and progression. Advanced imaging biomarkers may provide insights into cystic and non-cystic processes leading to kidney failure in different age groups.

Methods
This pilot study included 39 ADPKD patients with kidney failure, stratified into three age groups (&lt;46, 46–56, &gt;56 years old). Advanced imaging biomarkers were assessed using an automated instance cyst segmentation tool. The biomarkers were compared with an age- and sex-matched ADPKD cohort in early chronic kidney disease (CKD).

Results
Ht-total parenchymal volume correlated negatively with age at kidney failure. The median Ht-total parenchymal volume was significantly lower in patients older than 56 years. Cystic burden was significantly higher at time of kidney failure, especially in patients who reached it before age 46 years. The cyst index at kidney failure was comparable across age groups and Mayo Imaging Classes. Advanced imaging biomarkers showed higher correlation with Ht-total kidney volume in early CKD than at kidney failure. Cyst index and parenchymal index were relatively stable over 5 years prior to kidney failure, whereas Ht-total cyst volume and cyst parenchymal surface area increased significantly.

Conclusion
Age-related differences in advanced imaging biomarkers suggest variable pathophysiological mechanisms in ADPKD patients with kidney failure. Further studies are needed to validate the utility of these biomarkers in predicting disease progression and guiding treatment strategies.
Changes in laboratory results in transgender individuals on hormone therapy: a retrospective study and practical approach
Authors: Boekhout-Berends Evelien T M , Wiepjes Chantal M , Nota Nienke M , Schotman Hans H M , Heijboer Annemieke C , den Heijer Martin 
Published: May 2023

Abstract

Objective
Interpreting laboratory results for transgender individuals who started hormone therapy requires careful consideration, specifically for analytes that have sex-specific reference intervals. In literature, conflicting data exist on the effect of hormone therapy on laboratory parameters. By studying a large cohort, we aim to define what reference category (male or female) is most appropriate to use for the transgender population over the course of gender-affirming therapy.

Methods
A total of 2201 people (1178 transgender women and 1023 transgender men) were included in this study. We analyzed hemoglobin (Hb), hematocrit (Ht), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), creatinine, and prolactin, at 3 different time points: pretreatment, during hormone therapy, and after gonadectomy.

Results
For transgender women, Hb and Ht levels decrease after initiation of hormone therapy. The concentration of liver enzymes ALT, AST, and ALP decreases whereas the levels of GGT do not change statistically significantly. Creatinine levels decrease whereas prolactin levels rise in transgender women during gender-affirming therapy. For transgender men, Hb and Ht values increase after starting hormone therapy. Liver enzymes and creatinine levels increase statistically significantly as well upon hormone therapy while prolactin concentrations decrease. Overall, reference intervals in transgender people after 1 year on hormone therapy resembled those of their affirmed gender.

Conclusions
Generating transgender-specific reference intervals is not essential to correctly interpret laboratory results. As a practical approach, we recommend to use the reference intervals of the affirmed gender from 1 year onwards after starting hormone therapy.
Previous antithrombotic therapy does not have an impact on the in-hospital mortality of patients with upper gastrointestinal bleeding
Authors: Hozman Marek , Hassouna Sabri , Grochol Lukas , Waldauf Petr , Hracek Tomas , Pazdiorova Blanka Zborilova , Adamec Stanislav , Osmancik Pavel 
Published: May 2023

Abstract
The association between antithrombotics (ATs) and the risk of gastrointestinal bleeding is well known; however, data regarding the influence of ATs on outcomes are scarce. The goals of this study are: (i) to assess the impact of prior AT therapy on in-hospital and 6-month outcomes and (ii) to determine the re-initiation rate of the ATs after a bleeding event. All patients with upper gastrointestinal bleeding (UGB) who underwent urgent gastroscopy in three centres from 1 January 2019 to 31 December 2019 were retrospectively analysed. Propensity score matching (PSM) was used. Among 333 patients [60% males, mean age 69.2 (±17.3) years], 44% were receiving ATs. In multivariate logistic regression, no association between AT treatment and worse in-hospital outcomes was observed. Development of haemorrhagic shock led to worse survival [odds ratio (OR) 4.4, 95% confidence interval (CI) 1.9–10.2, P &lt; 0.001; after PSM: OR 5.3, 95% CI 1.8–15.7, P = 0.003]. During 6-months follow-up, higher age (OR 1.0, 95% CI 1.0–1.1, P = 0.002), higher comorbidity (OR 1.4, 95% CI 1.2–1.7, P &lt; 0.001), a history of cancer (OR 3.6, 95% CI 1.6–8.1, P &lt; 0.001) and a history of liver cirrhosis (OR 2.2, 95% CI 1.0–4.4, P = 0.029) were associated with higher mortality. After a bleeding episode, ATs were adequately re-initiated in 73.8%. Previous AT therapy does not worsen in-hospital outcomes in after UGB. Development of haemorrhagic shock predicted poor prognosis. Higher 6-month mortality was observed in older patients, patients with more comorbidities, with liver cirrhosis and cancer.
Physical activity levels and statin therapy: differences between symptomatic and asymptomatic statin users
Authors: Allard N A E , Bakker E A , Janssen L , Baltussen D C J , Hopman M T E , Timmers S , Assendelft W J J , Van De Laar F A 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Combining statin treatment and physical activity is highly effective to reduce cardiovascular diseases. Statin use may exacerbate statin-associated muscle symptoms (SAMS), making an active lifestyle more difficult for statin users. It is, however, unknown whether daily activity patterns differ between symptomatic and asymptomatic statin users.

Purpose
To objectively assess physical activity levels and sedentary time and compare these between long-term statin users with or without muscle complaints.

Methods
Ninety-seven symptomatic (66±9 years, 74% male) and 97 asymptomatic statin users, matched for age and gender in a 1:1 ratio, were recruited from general practitioners offices. Physical activity patterns were measured using the activPAL3 micro monitor, which was attached to the upper right thigh. Participants wore the activity monitor 24 hours per day during 7 consecutive days and were asked to maintain normal daily activities.

Results
Symptomatic statin users performed less physical activity of moderate to vigorous intensity per day (61.1 min, IQR: 43.1-77.0 min) compared to asymptomatic statin users (69.1 min, IQR: 50.7-94.6 min; P=0.02). There were no differences in physical activity levels of light intensity or sedentary time between the statin groups. Symptomatic statin users took less steps per day (7560 steps, IQR: 5649-9692 steps) compared to asymptomatic statins users (8721 steps, IQR 6306-11791 steps; P=0.02).

Conclusion
Symptomatic statin users have reduced levels of physical activity compared to asymptomatic statin users. These findings highlight the clinical relevance to explore possibilities for symptomatic statin users to increase physical activity levels and the associated health benefits.
Sodium content in Swedish processed food items compared to other countries
Authors: Karlsson K , Radholm K , Dunford E , Wu J , Neal B , Sundstrom J 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Dietary sodium has a dose-response relationship with cardiovascular disease, and sodium intake in Sweden exceeds national and international recommendations. Two thirds of dietary sodium intake comes from processed foods, and adults in Sweden eat more processed foods than any other European country. We hypothesised that sodium content in Swedish processed foods is higher than other countries due to the high sodium intake in the Swedish population.

Purpose
To investigate sodium content in Swedish processed food items, and how it differs from Australia, France, Hong Kong, South Africa, the United Kingdom and the United States.

Method
Data were collected from retailers by trained research staff using standardised methods. Ten food categories were compared using Kruskal-Wallis test of ranks.

Results
Compared to other countries, Sweden had among the highest sodium content in the ‘dairy’ and ‘convenience foods’ categories, but among the lowest in ‘cereal and grain products’, ‘seafood and seafood products’ and ‘snack foods’ categories. The highest sodium contents in the Swedish data were found in the ‘meat and meat products’ category.

Conclusion
Contrary to our hypothesis, Swedish processed foods had overall lower sodium content than most other included countries. Sodium content differed substantially between countries in all food categories. Swedish foods had higher sodium content than other countries in increasingly consumed food categories.