bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid-Derived Suppressor–Cell Dynamics Control Outcomes in the Metastatic Niche
Authors: Kreger Jesse , Roussos Torres Evanthia T. , MacLean Adam L. 
Published: February 2023

Abstract
Myeloid-derived suppressor cells (MDSC) play a prominent role in the tumor microenvironment. A quantitative understanding of the tumor–MDSC interactions that influence disease progression is critical, and currently lacking. We developed a mathematical model of metastatic growth and progression in immune-rich tumor microenvironments. We modeled the tumor–immune dynamics with stochastic delay differential equations and studied the impact of delays in MDSC activation/recruitment on tumor growth outcomes. In the lung environment, when the circulating level of MDSCs was low, the MDSC delay had a pronounced impact on the probability of new metastatic establishment: blocking MDSC recruitment could reduce the probability of metastasis by as much as 50%. To predict patient-specific MDSC responses, we fit to the model individual tumors treated with immune checkpoint inhibitors via Bayesian parameter inference. We reveal that control of the inhibition rate of natural killer (NK) cells by MDSCs had a larger influence on tumor outcomes than controlling the tumor growth rate directly. Posterior classification of tumor outcomes demonstrates that incorporating knowledge of the MDSC responses improved predictive accuracy from 63% to 82%. Investigation of the MDSC dynamics in an environment low in NK cells and abundant in cytotoxic T cells revealed, in contrast, that small MDSC delays no longer impacted metastatic growth dynamics. Our results illustrate the importance of MDSC dynamics in the tumor microenvironment overall and predict interventions promoting shifts toward less immune-suppressed states. We propose that there is a pressing need to consider MDSCs more often in analyses of tumor microenvironments.
Comparison between horizontal and vertical axis wind turbine
Authors: Al-Rawajfeh Mohammad A. , Gomaa Mohamed R. 
Published: February 2023

Since ancient times, wind energy has been exploited in various fields, it was at the beginning used to rotate pumps for the purposes of agriculture and irrigation. At the beginning of the 18th century, wind turbines began to produce electricity with modest capacities. In the following years, the capacities of the turbines increased and it became necessary to deal with this increase by reducing losses and inventing new designs for turbines Suitable for working conditions and installation location. The rotor power coefficient in a wind turbine can reach 0.59 which is called the bets limit. The vertical axis wind turbine (VAWT) design was invented for working conditions, capacities, and places, in which it may be difficult to install older Horizontal axis wind turbines (HAWT). The efficiency of the HAWT is still higher than the VAWT, in addition, the amount of efficiency in the HAWT is greater than the VAWT by 25% but the VAWT has the amount of torque more than the HAWT. The main objective of this research is to compare the VAWT and the HAWT, taking into account several aspects which have been reviewed to try to understand the importance of the two designs.
Multimodal Comparisons of Results Achieved by Different Side Branch Ballooning Techniques for Bifurcation Provisional Stenting
Authors: Bianchini Francesco , Cangemi Stefano , DeVos Amanda , Bielecki Michael , Aurigemma Cristina , Romagnoli Enrico , Trani Carlo , Iaizzo Paul Anthony , Burzotta Francesco 
Published: February 2023

Background:
Stepwise provisional stenting is the gold standard for percutaneous coronary intervention (PCI) on bifurcation lesions, but the optimal ballooning technique for eventual side branch treatment is not established. The objective of the present study was to compare the stent configuration obtained by 2 different side branch optimization techniques performed after main vessel (MV) stent implantation: proximal optimization technique+kissing balloon inflation+final proximal optimization technique (POT/KBI/POT [PKP]) versus proximal optimization technique+isolated side branch dilation+final proximal optimization technique (POT-side-POT [PSP]).

Methods:
We realized a 1:1 prospective randomized trial comparing bifurcation PCI conducted (under angiographic and angioscopic visualization) with either PKP or PSP in reanimated swine hearts using commercially available drug-eluting stents. After PCI, the obtained stent configuration (expansion, eccentricity, apposition) was assessed by optical coherence tomography and micro-computed tomography dividing the stent in 4 segments. Primary study end point was minimum stent expansion at the distal MV segment.

Results:

A total of 30 PCIs were successfully performed according to randomization obtaining overall good results (average minimum stent expansion >90% at optical coherence tomography and micro-computed tomography) with PSP or PKP. Minimum stent expansion at the distal MV segment was significantly higher with PKP as compared with PSP at optical coherence tomography (97.9±4.2% versus 91.0±7.7%;
P
=0.002) and micro-computed tomography (98.1±4.1% versus 91.3±7.9%;
P
=0.006). Other significant findings included higher stent eccentricity index at proximal MV with PSP, higher side branch scaffolding length and lower malapposition (at bifurcation core and distal MV) with PKP.

Conclusions:
This first prospective randomized trial in a unique non-atherosclerotic preclinical environment showed that bifurcation PCI conducted with PSP and PKP achieves different stent configurations. These findings might be useful in bifurcation PCI practice and call for further evaluations in clinical ground.
Sex‐Specific Risk Factors for Deep Venous Thrombosis and Pulmonary Embolism in a Population‐Based Historical Cohort Study of Middle‐Aged and Older Individuals
Authors: Brink Annie , Elf Johan , Svensson Peter J. , Engström Gunnar , Melander Olle , Zöller Bengt 
Published: February 2023

Background
Whether sex‐specific differences exist for risk factors for pulmonary embolism (PE) and deep venous thrombosis (DVT), with the exception of pregnancy and estrogen therapy, has been sparsely studied. We aimed to study whether sex‐specific differences of risk factors exist for noncancer‐related DVT and PE in middle‐aged and older individuals without cardiovascular history or previous diagnosis in a population‐based historical (retrospective) cohort.

Methods and Results
Potential venous thromboembolism (VTE) risk factors were registered at baseline in 15 807 women and 9996 men aged 44 to 74 years, who participated in the Malmö Diet and Cancer study (1991–1996). We excluded subjects with a previous history of VTE, cancer, a diagnosis of cardiovascular disease, or a diagnosis of cancer‐associated VTE during follow‐up. Patients were followed up from baseline until the first event of PE or DVT, death, or December 31, 2018. During the follow‐up period, 365 (2.3%) women and 168 (1.7%) men were affected by first DVT, and 309 (2.0%) women and 154 (1.5%) men were affected by first PE. In the multivariable Cox regression models, the anthropometric obesity markers of weight, body mass index, waist and hip circumference, fat percentage, and muscle weight were in a dose‐dependent way associated with DVT and PE among women but not men. In an analysis that included patients with cardiovascular disease and cancer‐related VTE, the results were similar for women. For men, several obesity measures became significantly associated with PE or DVT but were weaker than in women, especially for DVT.

Conclusions
Anthropometric obesity measures are more important risk factors for both DVT and PE among women than men, especially for individuals without cardiovascular history or previous diagnosis or cancer‐related VTE.
Impact of Time to Treatment on Endovascular Thrombectomy Outcomes in the Early Versus Late Treatment Time Windows
Authors: Asdaghi Negar , Wang Kefeng , Gardener Hannah , Jameson Angus , Rose David Z. , Alkhachroum Ayham , Gutierrez Carolina M. , Ying Hao , Mueller-Kronast Nils , Sur Nicole B. , Dong Chuanhui , Gordon Perue Gillian , LePain Marissa , Koch Sebastian , Krementz Nastajjia , Marulanda-Londoño Erika , Hanel Ricardo , Mehta Brijesh , Yavagal Dileep R. , Rundek Tatjana , Sacco Ralph L. , Romano Jose G. ,   for the Florida Stroke Registry*
Published: February 2023

Background:
The impact of time to treatment on outcomes of endovascular thrombectomy (EVT) especially in patients presenting after 6 hours from symptom onset is not well characterized. We studied the differences in characteristics and treatment timelines of EVT-treated patients participating in the Florida Stroke Registry and aimed to characterize the extent to which time impacts EVT outcomes in the early and late time windows.

Methods:
Prospectively collected data from Get With the Guidelines–Stroke hospitals participating in the Florida Stroke Registry from January 2010 to April 2020 were reviewed. Participants were EVT patients with onset-to-puncture time (OTP) of ≤24 hours and categorized into early window treated (OTP ≤6 hours) and late window treated (OTP >6 and ≤24 hours). Association between OTP and favorable discharge outcomes (independent ambulation, discharge home and to acute rehabilitation facility) as well as symptomatic intracerebral hemorrhage and in-hospital mortality were examined using multilevel-multivariable analysis with generalized estimating equations.

Results:

Among 8002 EVT patients (50.9% women; median age [±SD], 71.5 [±14.5] years; 61.7% White, 17.5% Black, and 21% Hispanic), 34.2% were treated in the late time window. Among all EVT patients, 32.4% were discharged home, 23.5% to rehabilitation facility, 33.7% ambulated independently at discharge, 5.1% had symptomatic intracerebral hemorrhage, and 9.2% died. As compared with the early window, treatment in the late window was associated with lower odds of independent ambulation (odds ratio [OR], 0.78 [0.67–0.90]) and discharge home (OR, 0.71 [0.63–0.80]). For every 60-minute increase in OTP, the odds of independent ambulation reduced by 8% (OR, 0.92 [0.87–0.97];
P
<0.001) and 1% (OR, 0.99 [0.97–1.02];
P
=0.5) and the odds of discharged home reduced by 10% (OR, 0.90 [0.87–0.93];
P
<0.001) and 2% (OR, 0.98 [0.97–1.00];
P
=0.11) in the early and late windows, respectively.

Conclusions:
In routine practice, just over one-third of EVT-treated patients independently ambulate at discharge and only half are discharged to home/rehabilitation facility. Increased time from symptom onset to treatment is significantly associated with lower chance of independent ambulation and ability to be discharged home after EVT in the early time window.
Care Is a Relationship
Authors: Slaughter Anne-Marie 
Published: February 2023

Abstract
Care, defined as caregiving, should be understood as a relationship rather than an activity: a relationship of nurture and development that imbues a set of actions, or “services,” with a positive impact on the person or being that is cared for. Valuing care as part of a new moral political economy will thus require figuring out how to value relationships apart from goods and services. Moreover, care is a relationship that is grounded more in identity than reciprocity: an expansion of the self to embrace the interests of others as one's own. From this perspective, mutuality and solidarity are just as natural an expression of the human condition as reciprocity, proceeding from identity rather than individuation.
Biophilic Markets
Authors: Beinhocker Eric D. 
Published: February 2023

Abstract
Markets must be made biophilic: that is, compatible with life flourishing on Earth. To do so, we must abandon prevailing notions of market efficiency and reconceive markets as social evolutionary systems embedded in nature. Such a reconception enables us to see that constraining markets within biophysical boundaries would not result in zero-sum trade-offs with the economy, but instead would drive market evolution to new forms of prosperity.
Unchaining Workers
Authors: Charo R. Alta 
Published: February 2023

Abstract
An influential report on protecting the medical supply chain in the next pandemic fails to include a commitment to protecting the workers who protect the supply chain. The securing strategy outlined by Richard Locke, Ben Armstrong, Samantha Schaab-Rozbicki, and Geordie Young offers examples of such an approach, and the analytical framework for protecting the chain-awareness, mitigation, preparedness, and response-can be applied equally well to the workforce. Considerations of equity and fairness should lead us to unchain the workers strung along the chain of medical and consumer supplies.
Is There a Proper Scope for Markets?
Authors: Fleurbaey Marc 
Published: February 2023

Abstract
Debra Satz's brilliant essay highlights that it is insufficient to study markets in terms of efficiency and potential market failures, as they have deep effects on people and societies. This line of thought could inspire the project of building a general theory of social interactions, in which the specific properties of market transactions would be identified, and their influence on society at large, depending on the surrounding institutions and social structure, could be understood. In this brief essay, personal care provides an example of the complex ramifications of different arrangements for social interactions.
Are Moral Firms Committed Firms?
Authors: Mayer Colin 
Published: February 2023

Abstract
Corporate purpose is everywhere, but will it stay? Is it a business revolution or a passing fad, destined to go the way of so many business concepts? Reliance on the good judgment and goodwill of corporate leaders is a justifiable cause for concern, and resort is often sought instead in the apparently safe harbor of public regulation. But reliance should not be placed on governments and regulators alone to constrain the corporate giants in the face of a system that motivates abusive behavior. Instead, attention should be devoted to alignment of the intrinsic interests of corporations with those of society more generally.
“We're all in this fight together”: African American and Latinx Parent-Activists in Boston Schools
Authors: M. F. Cruz Tatiana 
Published: February 2023

Abstract
This essay examines the parallel African American and Latinx educational movements in the decades prior to mandated school desegregation or the “busing crisis” of 1974. It focuses on working-class mother-activists who employed various organizing strategies in the pursuit of educational justice in the Jim Crow North.
Geostrophic Eddies Spread Near-Inertial Wave Energy to High Frequencies
Authors: Dong Wenjing , Bühler Oliver , Smith K. Shafer 
Published: February 2023

Abstract
The generation of broadband wave energy frequency spectra from narrowband wave forcing in geophysical flows remains a conundrum. In contrast to the long-standing view that nonlinear wave–wave interactions drive the spreading of wave energy in frequency space, recent work suggests that Doppler-shifting by geostrophic flows may be the primary agent. We investigate this possibility by ray tracing a large number of inertia–gravity wave packets through three-dimensional, geostrophically turbulent flows generated either by a quasigeostrophic (QG) simulation or by synthetic random processes. We find that, in all cases investigated, a broadband quasi-stationary inertia–gravity wave frequency spectrum forms, irrespective of the initial frequencies and wave vectors of the packets. The frequency spectrum is well represented by a power law. A possible theoretical explanation relies on the analogy between the kinematic stretching of passive tracer gradients and the refraction of wave vectors. Consistent with this hypothesis, the spectrum of eigenvalues of the background flow velocity gradients predicts a frequency spectrum that is nearly identical to that found by integration of the ray tracing equations.
Post hoc longitudinal assessment of the efficacy and safety of recombinant factor IX Fc fusion protein in hemophilia B
Authors: Shapiro Amy D. , Kulkarni Roshni , Ragni Margaret V. , Chambost Hervé , Mahlangu Johnny , Oldenburg Johannes , Nolan Beatrice , Ozelo Margareth C. , Foster Meredith C. , Willemze Annemieke , Barnowski Christopher , Jain Nisha , Winding Bent , Dumont Jennifer , Lethagen Stefan , Barnes Chris , Pasi K. John 
Published: February 2023

Abstract
Long-term efficacy and safety of the extended half-life recombinant factor IX Fc fusion protein (rFIXFc) has been established among previously treated patients with severe hemophilia B in 2 phase 3 trials (B-LONG [#NCT01027364] and Kids B-LONG [#NCT01440946]) and a long-term extension study (B-YOND [#NCT01425723]). In this study, we report post hoc analyses of pooled longitudinal data for up to 6.5 years for rFIXFc prophylaxis. In the B-LONG study, subjects ≥12 years received weekly dose-adjusted prophylaxis (WP; starting dose, 50 IU/kg), individualized interval-adjusted prophylaxis (IP; initially, 100 IU/kg every 10 days), or on-demand dosing. In the Kids B-LONG study, subjects &lt;12 years received 50 to 60 IU/kg every 7 days, adjusted as needed. In the B-YOND study, subjects received WP (20-100 IU/kg every 7 days), IP (100 IU/kg every 8-16 days), modified prophylaxis, or on-demand dosing; switching between treatment groups was permitted. A total of 123 subjects from B-LONG and 30 from Kids B-LONG study were included, of whom 93 and 27, respectively, enrolled in the B-YOND study. The median cumulative duration of treatment was 3.63 years (range, 0.003-6.48 years) in B-LONG/B-YOND and 2.88 years (range, 0.30-4.80 years) in Kids B-LONG/B-YOND group. Annualized bleed rates (ABRs) remained low, annualized factor consumption remained stable, and adherence remained high throughout treatment. Low ABRs were also maintained in subjects with dosing intervals ≥14 days or with target joints at baseline. Complete resolution of evaluable target joints and no recurrence in 90.2% of baseline target joints during follow-up were observed. rFIXFc prophylaxis was associated with sustained clinical benefits, including long-term bleed prevention and target joint resolution, for severe hemophilia B.
Reconstructing B cell lineage trees with minimum spanning tree and genotype abundances
Authors: Abdollahi Nika , Jeusset Lucile , de Septenville Anne , Davi Frederic , Bernardes Juliana Silva 
Published: February 2023

AbstractB cell receptor (BCR) genes exposed to an antigen undergo somatic hypermutations and Darwinian antigen selection, generating a large BCR-antibody diversity. This process, known as B cell affinity maturation, increases antibody affinity, forming a specific B cell lineage that includes the unmutated ancestor and mutated variants. In a B cell lineage, cells with a higher antigen affinity will undergo clonal expansion, while those with a lower affinity will not proliferate and probably be eliminated. Therefore, cellular (genotype) abundance provides a valuable perspective on the ongoing evolutionary process. Phylogenetic tree inference is often used to reconstruct B cell lineage trees and represents the evolutionary dynamic of BCR affinity maturation. However, such methods should process B-cell population data derived from experimental sampling that might contain different cellular abundances. There are a few phylogenetic methods for tracing the evolutionary events occurring in B cell lineages; best-performing solutions are time-demanding and restricted to analysing a reduced number of sequences, while time-efficient methods do not consider cellular abundances. We propose ClonalTree, a low-complexity and accurate approach to construct B-cell lineage trees that incorporates genotype abundances into minimum spanning tree (MST) algorithms. Using both simulated and experimental data, we demonstrate that ClonalTree outperforms MST-based algorithms and achieves a comparable performance to a method that explores tree-generating space exhaustively. Furthermore, ClonalTree has a lower running time, being more convenient for building B-cell lineage trees from high-throughput BCR sequencing data, mainly in biomedical applications, where a lower computational time is appreciable. It is hundreds to thousands of times faster than exhaustive approaches, enabling the analysis of a large set of sequences within minutes or seconds and without loss of accuracy. The source code is freely available at github.com/julibinho/ClonalTree.
Reporting quality of scoping reviews in dental public health
Authors: Dotto Lara , dos Santos Mateus Bertolini Fernandes , Sarkis-Onofre Rafael 
Published: February 2023

Abstract
Background
The study aimed to explore reporting characteristics of scoping reviews in dental public health and the impact of some factors on the reporting quality.

Methods
This study searched for dental public health scoping reviews in PubMed and Scopus without year restrictions and restricted to English-language publications. Study selection was undertaken by two reviewers independently. One reviewer, after training, extracted data from included studies considering general study characteristics and reporting characteristics. The impact of PRISMA-ScR publication, journal endorsement, and use of study protocol on the reporting was explored.

Results
Eighty-one scoping reviews were included. Five items presented rates of appropriate reporting higher than 80% considering the overall percentage. Related to the impact of PRISMA-ScR publication, six items were found more often in scoping reviews published after the publication of PRISMA-ScR than in scoping reviews published before the publication of PRISMA-ScR. With regards to journals endorsement, only two reporting characteristics were found more often in scoping reviews published in journals that endorse the PRISMA-ScR statement than in scoping reviews published in non-endorsers journals. Last, regarding the use of the pre-specified protocol, five reporting characteristics presented differences in studies reporting the use of pre-specified protocol than in studies that did not mention the use of a protocol. All differences were statistically significant.

Conclusions
Important information is missing in the included scoping reviews demonstrating crucial reporting problems.
Practical basket design for binary outcomes with control of family-wise error rate
Authors: Asano Junichi , Sato Hiroyuki , Hirakawa Akihiro 
Published: February 2023

Abstract
Background
A basket trial is a type of clinical trial in which eligibility is based on the presence of specific molecular characteristics across subpopulations with different cancer types. The existing basket designs with Bayesian hierarchical models often improve the efficiency of evaluating therapeutic effects; however, these models calibrate the type I error rate based on the results of simulation studies under various selected scenarios. The theoretical control of family-wise error rate (FWER) is important for decision-making regarding drug approval.

Methods
In this study, we propose a new Bayesian two-stage design with one interim analysis for controlling FWER at the target level, along with the formulations of type I and II error rates. Since the difficulty lies in the complexity of the theoretical formulation of the type I error rate, we devised the simulation-based method to approximate the type I error rate.

Results
The proposed design enabled adjustment of the cutoff value to control the FWER at the target value in the final analysis. The simulation studies demonstrated that the proposed design can be used to control the well-approximated FWER below the target value even in situations where the number of enrolled patients differed among subpopulations.

Conclusions
The accrual number of patients is sometimes unable to reach the pre-defined value; therefore, existing basket designs may not ensure defined operating characteristics before beginning the trial. The proposed design that enables adjustment of the cutoff value to control FWER at the target value based on the results in the final analysis would be a better alternative.