bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-variant proof predictive vaccine design based on SARS-CoV-2 spike protein using immunoinformatics approach
Authors: Sahu Lavanya Kumar , Singh Kiran 
Published: January 2023

Abstract
Background
Coronavirus Disease (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus is evolving continuously. The omicron variant of SARS-CoV-2 has the highest mutation in its spike protein, thus making the presently available vaccine ineffective or reducing its efficiency. Furthermore, the majority of the vaccines are constructed using a spike protein sequence from wild-type SARS-CoV-2. This raises the possibility of the virus evolving to the point where the vaccine's effectiveness is completely lost, even after booster doses. The study aims to develop a predictive vaccine as well as the epitopes for the updating of the vaccine sequences of currently available vaccines. In this study, following the immunoinformatics approach, predictive vaccine construction was done with the help of epitopes present on spike proteins of wild-type, delta, and omicron variants that encompass the majority of variants and possible new variants that arise from the combination of circulating variants.

Results
The vaccine that was constructed was stable and immunogenic. The vaccine was constructed with the help of 18 B-cell epitopes, 5 MHC class I epitopes, and 6 MHC class II epitopes. The epitope conservancy analysis suggests that the vaccine will work for the previously known variant of concern. The vaccine bound to TLR4, TLR2, B-cell receptor chains A and B, and ACE2 receptors with a z score of − 1.4, − 1.7, − 1.4, − 1.7, and − 1.4, respectively, with a cluster size of 121 highest for the ACE2 receptor and 46 lowest for B-cell receptor chain A. The C-ImmSim simulation results indicate that the vaccine is generating both humoral and cell-mediated responses at a sufficient level throughout the month upon injection of the vaccine as an antigen.

Conclusion
The study's findings indicate that the vaccine was both stable and immunogenic, providing a sufficient level of immunity. Following experimental validation, the vaccine can be used, and the epitopes can be employed for therapeutic purposes such as antibody synthesis.

Graphical Abstract
Characteristics and clinical outcomes of patients with lung cancer requiring ICU admission: a retrospective analysis based on the MIMIC-III database
Authors: Qian Jie , Qin Ruoyan , Hong Liang , Shi Yangyang , Yuan Haibin , Zhang Bo , Nie Wei , Li Yanwen , Han Baohui 
Published: January 2023

Abstract
Background
Lung cancer (LC) is the most common solid tumor type in the intensive care unit (ICU). This study investigated the characteristics of LC patients admitted to the ICU, the major reasons for their admission, short-term mortality, and associated risk factors.

Methods
Patients with LC were retrospectively identified in the publicly available, large-scale, single-center database Medical Information Mart for Intensive Care (MIMIC) III. Demographic and clinical characteristics, including age, sex, smoking history, comorbidities, type of admission to ICU, major diagnoses, illness severity score as assessed by the Simplified Acute Physiology Score (SAPS) II and the Sequential Organ Failure Assessment (SOFA), ICU length of stay (LOS), use of mechanic ventilation (MV) or vasopressors, the existence of do-not-resuscitate (DNR) orders, and metastatic status were collected. The major reasons for ICU admission were analyzed in subgroups. The multivariate logistic regression analysis was used to determine the factors associated with the 28-day and 6-month mortality.

Results
A total of 1242 ICU admissions were included. Diseases of respiratory (42.7%), nervous (14.3%), and cardiovascular (11.9%) systems accounted for the top reasons for admission. Pneumonia/pneumonitis, respiratory failure, and sepsis were the primary reasons for ICU admission. The median survival was 2.93 (95% CI: 2.42–3.43) months. The 28-day inhospital and the 6-month mortality were 30.6% and 68.2%, respectively. Sepsis (63.9%), respiratory failure (47.0%), and pleural effusion (40.9%) accounted for the top three highest 28-day ICU mortality in all causes. An age ≥ 65 years, a SAPS II ≥ 37, a SOFA ≥ 3, metastasis, and MV use were independent risk factors for an inferior 28-day survival rate, while only metastatic status and SOFA score were associated with the 6-month mortality. SAPS II was accepatable and better than SOFA in predicting 28-day ICU [area under the curve (AUC): 0.714 and 0.658, respectively] or 28-day inhospital mortality (AUC: 0.717 and 0.660, respectively).

Conclusion
The 6-month prognosis for LC patients admitted to ICU was dismal. Multidisciplinary collaboration between intensivists and oncologists to identify high-risk patients and to determine a risk-benefit ratio of ICU treatment may improve survival prospects.
Enhanced Recovery Stem-Cell Transplantation: Multidisciplinary Efforts to Improve Outcomes in Older Adults Undergoing Hematopoietic Stem-Cell Transplant
Authors: Ngo-Huang An , Ombres Rachel , Saliba Rima M. , Szewczyk Nicholas , Adekoya LaToya , Soones Tacara N. , Ferguson Jill , Fontillas Rhodora C. , Gulbis Alison M. , Hosing Chitra , Kebriaei Partow , Lindsay Richard , Marin David C. , Mehta Rohtesh S. , Alousi Amin M. , Srour Samer , Oran Betul , Olson Amanda L. , Qazilbash Muzaffar H. , Rivera Zandra , Champlin Richard E. , Shpall Elizabeth J. , Popat Uday R. 
Published: January 2023

PURPOSE: Older adults have unique risk factors for poor outcomes after hematopoietic stem-cell transplant (HSCT). We sought to determine the impact of our multidisciplinary supportive care program, Enhanced Recovery after stem-cell transplant (ER-SCT), on survival outcomes in patients age 65 years and older who underwent HSCT. PATIENTS AND METHODS: In this retrospective study, clinicodemographic data, nonrelapse mortality (NRM), overall survival (OS), and relapse were compared between 64 patients age 65 years and older who underwent allogeneic stem-cell transplant during ER-SCT program's first year, October 2017 through September 2018, and 140 historical controls age 65 years and older who underwent allogeneic HSCT, January 2015 through September 2017. RESULTS: In the ER-SCT cohort, 41% (26 of 64) of patients were women, and the median (range) age was 68 (65-74) years; in the control cohort, 38% (53 of 140) of patients were women, and the median (range) age was 67 (65-79) years. Hematopoietic cell transplant comorbidity index and donor type/cell source were similar between cohorts. The ER-SCT cohort had a lower 1-year NRM rate (13% v 26%, P = .03) and higher 1-year OS rate (74% v 53%, P = .007). Relapse rate did not differ significantly between cohorts. In multivariate analyses, ER-SCT was associated with improved 1-year NRM (hazard ratio, 0.4; 95% CI, 0.2 to 0.9; P = .02) and improved 1-year OS (hazard ratio, 0.5; 95% CI, 0.3 to 0.9; P = .03). CONCLUSION: A multidisciplinary supportive care program may improve NRM and OS in older patients undergoing allogeneic HSCT. Randomized studies are warranted to confirm this benefit and explore which program components most contribute to the improved outcomes.
Thermal performance of gasifier cooking stoves: A systematic literature review
Authors: Rabby Md Insiat Islam , Uddin Md Wasi , Sheikh Mahafuzur Rahman , Bhuiyan Humayun Kabir , Mumu Tazeen Afrin , Islam Fabliha , Sultana Afsana 
Published: January 2023

A systematic literature review was conducted to summarize the overall thermal performance of different gasified cooking stoves from the available literature. For this purpose, available studies from the last 14 years (2008 to 2022) were searched using different search strings. After screening, a total of 28 articles were selected for this literature review. Scopus, Google Scholar, and Web of Science databases were used as search strings by applying “Gasifier cooking stove” AND “producer gas cooking stove” AND “thermal performance” keywords. This review uncovers different gasified cooking stoves, cooking fuels, and fabrication materials besides overall thermal performances. The result shows that the overall thermal performance of different gasified cooking stoves was 5.88% to 91% depending on the design and burning fuels. The premixed producer gas burner with a swirl vane stove provided the highest overall thermal performance range, which was 84% to 91%, and the updraft gasified stove provided the lowest performance, which was 5.88% to 8.79%. The result also demonstrates that the wood pellets cooking fuel provided the highest thermal performance and corn straw briquette fuel provided the lowest for gasified cooking stoves. The overall thermal performance of wood pellets was 38.5% and corn straw briquette was 10.86%.
Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: An observational study
Authors: H. Fadhel Mohammed , Faris Hassan Ali 
Published: January 2023

Background: Doxorubicin is a crucial anticancer medication, however, cardiotoxicity is a severe adverse effect of doxorubicin therapy. Various mechanisms, including inflammation, have been postulated to account for this negative effect. The omega-7 fatty acid is a polyunsaturated fatty acid with anti-inflammatory and antioxidant properties. Therefore, the study's objective was to see whether omega-7 had any possible protective benefits against doxorubicin-induced cardiotoxicity in male rats. Methods: 28 male Wister rats were split into four groups (seven per group). Group 1 (negative control): healthy animals received normal saline orally as the vehicle for eight successive days and were sacrificed on day nine. Group 2 (positive control): animals that received a single dose of doxorubicin hydrochloride (IP 15mg/kg) were sacrificed the next day. Group 3: the animals were administered omega-7 orally at a 100 mg/kg/day dose for eight days. A single injection of doxorubicin IP (15 mg/kg) was given on day nine. The animals were sacrificed on day 10. Group 4: the animal was administered omega-7 orally at a 300 mg/kg/day dose for eight days. A single injection of doxorubicin IP (15 mg/kg) was given on day nine. The animals were sacrificed on day 10. Serum was collected and used to measure lactate dehydrogenase, creatinine kinase-MB, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta. Results: Lactate dehydrogenase and creatinine kinase-MB levels in group 3 (100mg/kg) were significantly lower than in group 2 (p>0.05) and significantly lower in group 4 (300mg/kg) than in group 2. Tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta levels were considerably lower in the omega-7-treated groups (100 and 300mg/kg) than in the positive control group (p<0.05). Conclusion: Through a mechanism involving the reduction of inflammation, omega-7 may preserve the cardiac tissue against doxorubicin-induced damage.
The medication self-management work system of patients and informal carers from a human factors & ergonomics perspective: A scoping review protocol
Authors: Negoescu Eduard , Marcilly Romaric , Cromie Samuel , Koay Aaron , Grimes Tamasine 
Published: January 2023

Background: Healthcare is increasingly delivered closer to the patients’ homes, which increases the level of responsibility that patients and informal carers take for managing their medication-taking, although this is associated with hazards. Medication self-management has been conceptualised as work taking place in non-formal settings (e.g., households), which are complex systems. Human factors and ergonomics (HFE) models provide a framework for studying such systems. The Systems Engineering Initiative for Patient Safety (SEIPS) is one framework that considers work system elements and how they interact with each other to shape processes that lead to outcomes (e.g., safety). Given the increasing amount of diverse research on patient and carer work and on system-shaping factors, the objectives of this review are to: (i) identify available evidence in a structured and systems-oriented way, (ii) explore approaches that have been applied and (iii) highlight research gaps. Methods: An evidence-informed patient, public and carer involvement (PPCI) approach will be implemented at all post-protocol stages to ensure the relevance, uptake and translation of the scoping review. The review will systematically search MEDLINE, Embase, PsycInfo, CINAHL and Web of Science to identify relevant qualitative studies. The methodological approach will be guided by Johanna Briggs Institute methodology and will be reported according to the PRISMA-ScR standards. Data charting and qualitative content analysis directed by SEIPS will explore how the work system and its constituting elements have been described in the literature and identify specific gaps and opportunities for future research. Borrowing from realist approaches, included studies will be assessed in terms of richness and relevance to our review question. Discussion: Strengths of this scoping review include PPCI and a converging focus on medication safety, medication self-management and HFE. Ultimately, this approach will advance our understanding of this complex system and guide opportunities to broaden and strengthen the evidence base.
Proposal for policy change in the procedure of civil asset forfeiture
Authors: Tzenios Nikolaos 
Published: January 2023

Without the proper due process, the civil asset forfeiture procedure violates the constitutional rights of citizens. The proposal aims to address the current right granted to the police to seize the property of civilians. The authorizing laws established by the Assets Forfeiture Fund and the Equitable Sharing Program are problematic in offering a loophole for the abuse of the property rights of American citizens. While some states have abolished the practice, federal laws still support their enforcement. The deficiencies in the policies raise discussion of the issue of policies for profit as a major aspect of civil asset forfeiture. This proposal is to outlaw instances of civil asset forfeiture without due process on the federal level. On the state level, the preferred outcome would also include reform by repealing the laws allowing property seizure. The resistance to change in the legislature should be addressed by securing the success of the policy, taking advantage of the current unpopularity of unregulated asset forfeiture, and creating the base for integration of the process on the federal level. The proposal calls for identifying stakeholders, analyzing their views, and strengthening their support. The social and political opposition should be addressed by putting emphasis on fundamental American values. The action plan and implementation process are built upon efficient communication by the policy committee to engage stakeholders and the wider public in the process. With clearly defined priorities and budget allocation, the policy will ultimately evolve into a legislative and organizational tool. Using the strategies of ascertainment of stakeholders and reframing issues to ensure appeal to American values, the change at federal and state levels will be achievable. While the change will lead to debate, significant improvement and the protection of rights is attainable in due process.
Group Structure and Information Distribution on the Emergence of Collective Intelligence
Authors: Tang Ming , Liao Huchang 
Published: January 2023

More and more decision-making problems are being solved by groups. Collective intelligence is the ability of groups to perform well when solving complex problems. Thus, it is important to encourage collective intelligence to emerge from groups. In this study, we explore how two critical characteristics of groups, that is, group structure and individual knowledge in groups, influence the emergence of collective intelligence. To do this, we propose a measure for group structure using the collaboration network of a group and a measure for the distribution of individual knowledge in groups. Group structure is measured based on the intensities of links and whether the network is hierarchical or flat. The distribution of individual knowledge is measured from the perspective of whether group information is shared or unique. Social interactions among group members and individual changes in opinion are modeled based on a simulation technique. We find that unbalanced information distribution undermines group performance, whereas group structure can modify the effect of information distribution. We also find that groups with broadly distributed knowledge are good at solving complex problems. Funding: This work was supported by the National Natural Science Foundation of China [Grants 72171158, 71771156 and 71971145].
Synergist effect of antiretroviral therapy adherence and viral load suppression on quality of life of people with HIV/AIDS
Authors: Nurwijayanti Nurwijayanti , Rias Yohanes Andy , Nasution Nurhafizah , Samsudin Rinza Rahmawati , Priyono Djoko , Rosyad Yafi Sabila 
Published: January 2023

Aims: This study investigated the synergistic and independent effects of adherence to antiretroviral therapy (ART) and viral load on quality of life (QoL) among people with HIV/AIDS. Methods: This was a cross-sectional study of 129 patients with HIV/AIDS. The WHOQOL-BREF and the Morisky Medication Adherence Scale were used to measure QoL and adherence respectively. Information on viral load and CD4 cell count was obtained from patients' records and verified by a physician. An additive interaction method was used to estimate the synergistic effect of the linear regression. Findings: Patients who were adhering to ART and had an undetectable viral load had significantly higher scores on four domains of QoL − environment, physical health, social relationships and psychological − than those who were non-adherent. Moreover, ART adherence and undetectable viral load had a positive synergistic effect on QoL after controlling for covariate variables. Conclusion: Participants were more likely to have a good QoL if they had both undetectable viral loads and good ART adherence.
TBK1 and IRF3 are potential therapeutic targets in Enterovirus A71-associated diseases
Authors: Ji Wangquan , Sun Tiantian , Li Dong , Chen Shuaiyin , Yang Haiyan , Jin Yuefei , Duan Guangcai 
Published: January 2023

Background
Enterovirus A71 (EV-A71) is an important causative agent of hand-foot-and-mouth disease (HFMD) associated with enormous healthcare and socioeconomic burden. Although a range of studies about EV-A71 pathogenesis have been well described, the underlying molecular mechanism in terms of innate immune response is still not fully understood, especially the roles of TANK-binding kinase 1 (TBK1) and interferon-regulatory factor 3 (IRF3).

Methodology/principal findings
Here, we applied TBK1 inhibitor and IRF3 agonist, for the first time, to evaluate the antiviral activities of TBK1 and IRF3 in vivo. We found that, through regulating EV-A71-induced type I interferon (IFN) response, IRF3 agonist effectively alleviated EV-A71-induced illness, while TBK1 inhibitor aggravated disease progression. In addition, EV-A71 replication was suppressed in EVA-71-infected mice administrated with IRF3 agonist. On the other hand, more severe pathological alterations of neuronal degeneration, muscle fiber breaks, fractured or fused alveolar walls, and diffuse congestion occurred in EVA-71-infected mice treated with TBK1 inhibitor administration. Furthermore, we determined the concentrations of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), IL-1β, monocyte chemotactic protein-1 (MCP-1), and IL-10 in both lungs and brains of mice and found that TBK1 inhibitor promoted EV-A71-induced inflammatory response, while IRF3 agonist alleviated it, which was consistent with clinical manifestations and pathological alterations.

Conclusions
Collectively, our findings suggest that TBK1 and IRF3 are potential therapeutic targets in EV-A71-induced illness.
Entwicklung und Anwendung eines raumbezogenen Index für Mobilität
Authors: Rammert Alexander 
Published: January 2023

This paper discusses which methods can be used to operationalize mobility in German planning practice. In particular, the index methodology, which is rarely used in planning practice, is suitable for the systematic operationalization of complex phenomena such as mobility. After a short theoretical introduction, the concept of mobility will be operationalized step by step for indexing. For this purpose, in addition to a theoretical construction model for a mobility index, a science-based list of indicators necessary for its calculation is created. Subsequently, this spatial mobility index is calculated on the basis of accessibility and user survey data from the Berlin district of Pankow. As a result, the index clearly shows on maps where people have more or less mobility options. Thus, the mobility index provides a novel method for planning to identify high or low mobility in the study areas.
Systemic investigation of inetetamab in combination with small molecules to treat HER2-overexpressing breast and gastric cancers
Authors: Deng Lan , Zhao Le , Liu Lifen , Huang Haomin 
Published: January 2023

Abstract
Most patients with metastatic breast cancer or gastric cancer who are treated with trastuzumab, an anti-HER2 monoclonal antibody, become refractory to the drug within a year after the initiation of treatment. Although the combination of trastuzumab with pertuzumab produced synergetic effects in the treatment of HER2-overexpressing cancers, not all patients with HER2 overexpression benefited from the trastuzumab plus pertuzumab combination. To improve the clinical benefits of trastuzumab, we systemically investigated the combination of inetetamab (Cipterbin), an analog of trastuzumab, with a variety of small molecules, including tyrosine kinase inhibitors (TKIs) and chemotherapeutic agents in vivo. We showed that pan-TKIs-induced synergistic antitumor effects with inetetamab in the treatment of these two types of cancers and that adding chemotherapeutic agents to the existing TKI plus anti-HER2 monoclonal antibody combination strategies induced additional inhibitory effects, suggesting that such combination strategies may be choices for the treatment of these two tumors. Thus, combination therapies targeting distinct and broad pathways that are essential for tumor growth and survival can be effective for treating metastatic breast cancers and gastric cancers.
Numerical visualization of extensional flows in injection molding of polymer melts
Authors: Tseng Huan-Chang 
Published: January 2023

Abstract
Extensional flows generally take place in a channel with varied cross-sectional areas. During polymer processing with a variety of complex geometric features, it is difficult to separate extensional rates from shear rates in state-of-the-art predictive engineering tools of computational fluid dynamics. The recently proposed method of Tseng [Tseng, H.-C., “A Revisitation of Generalized Newtonian Fluids,” J Rheol 64 493–504 (2020)] decomposed the generalized strain rate as the characteristic shear and extensional rates via the rate-of-deformation tensor rotated along streamline coordinates. As validation for an isothermal center-gated disk flow, the predicted flow field profiles fairly matched the analytical solution for Newtonian fluid. Under injection molding simulations, an objective indicator is defined to visualize the colorful contours of extensional flows encountered in the gate-vicinity and the mid-plane of the cavity’s thickness direction, as well as contraction-expansion channels.