bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of the retinoids in topical treatment of skin diseases - the review of the literature
Authors: Szczuraszek Paulina , Szczuraszek Hugo , Sałata Piotr , Paluch Michał , Tomkiewicz Michał , Tomkiewicz Julia , Żuchnik Magda , Licak Gabriela , Bętkowska Paulina , Rybkowska Agnieszka 
Published: February 2023

INTRODUCTION:
Retinoids are a broad group of natural and synthetic compounds derived from vitamin A. Many studies have shown strong anti-aging effects, and they have also been shown to have therapeutic effects on acne vulgaris or psoriasis.
Vitamin A and its derivatives make the skin more elastic and smooth, cause a decrease in fine wrinkles and cause an increase in fibroblast activity and collagen fiber production.
Retinoid compounds regulate biological processes of the skin such as immune processes, angiogenesis, proliferation and differentiation.

THE AIM OF STUDY:
The purpose of this paper is to discuss the effects of retinoids and the use of the substances in skin diseases.

MATERIALS AND METHOD:
Literature review of PubMed, Google Scholar and Science Direct and evaluation of available randomized controlled trials using retinoids in terms of treatment effectiveness in terms of skin quality, anti-aging benefits use in dermatology.

CONCLUSIONS:
Vitamin A and its derivatives plays an important role in anty-aging prevention and treatment of skin diseases, such as acne vulgaris, psoriasis and photo-aging. There are still many ongoing studies and not known opportunities of its use to treat other skin diseases that we should be aware of and keep track of new papers that indicate such.
Microbial alterations of oral cavity and their association with Pancreatic Cancer
Authors: Radziejowska Zuzanna , Bielak Alicja , Gryta Jakub , Iwan Karolina , Janczewska Martyna , Kalicka Maria , Krysa Tomasz , Kolasa Agata , Szklarz Magdalena 
Published: February 2023

Introduction: Pancreatic Cancer (PC), while relatively infrequent, remains one of the deadliest cancers as a result of late diagnosis and absence of preventive measures. Over 50 % of patients diagnosed with PC already suffer metastasis. Combined with lack of effective treatment, the need arises for universal biomarkers specific to PC. In the last decades the importance of human microbiota in its upholding of the body homeostasis has been under radar, in special regards to its association to cancer. Several species of oral microbiome have been linked to increased or decreased risk of developing pancreatic cancer, most notably P.gingivalis and Fusobacteria.

Purpose of the study: The aim of this study is to collect and summarize existing evidence on connection of oral microbiome and pancreatic cancer, as well as to assess their potential use in diagnostics of PC .

Material and method: Literature review was performed, in English databases, using keywords : cancer, pancreatic cancer, pancreatic cancer prevention, oral microbiome, microbe variation, microbial biomarkers.

Results and conclusions: In our systematic review, evident differences between microbial architecture of PC patients and healthy individuals were observed. The data on association between microbiota and risk of developing cancer is limited, however it still provides evidence for relationship between microbial composition and incidence of pancreatic cancer.
Influence of excessive body weight on cancer development and prognosis
Authors: Bielak Alicja , Gryta Jakub , Iwan Karolina , Janczewska Martyna , Kalicka Maria , Krysa Tomasz , Kolasa Agata , Radziejowska Zuzanna , Szklarz Magdalena , Kutermankiewicz Jan 
Published: February 2023

Introduction and purpose
According to the WHO, overweight and obesity are defined as excessive or abnormal accumulation of adipose tissue, leading to deterioration of health. Excessive body weight is a constantly growing public health problem that has reached the scale of a pandemic. Currently, there is ample evidence that excess body weight increases the risk of developing cancer and worsens the prognosis. The aim of this review is to analyze the impact of overweight and obesity on cancer development and prognosis, and to elucidate pathogenesis.
State of knowledge
Based on the current state of knowledge in epidemiology, it is estimated that approximately 20% of all malignancies are related to excessive body weight. So far, there is sufficient evidence to support an association between excess body fat and 13 out of 24 cancer sites: esophagus, gastric cardia, colon, liver, gallbladder, pancreas, postmenopausal breast, endometrium, ovary, kidney, meningioma, thyroid and multiple myeloma. Adipose tissue cells produce growth factors, hormones and cytokines that can interfere with the regulation of cell growth and survival. Excess adipose tissue leads to systemic chronic inflammation, oxidative stress, insulin resistance, hyperinsulinemia, increase in sex hormones, increase in leptin levels and a decrease in adiponectin levels. This leads to DNA defects, stimulation of angiogenesis, cell proliferation and inhibition of apoptosis, and thus promotes the development of cancer. In addition, studies have estimated that excess body weight is responsible for 14% of cancer deaths in men and 20% in women.
Conclusions
Due to the increasing problem of obesity and cancer worldwide and the proven causal relationship between these diseases, it is necessary to intensify nutrition education and promote a healthy lifestyle in order to minimize excessive body weight, and thus reduce the incidence of cancer.
Ventres livres? Pensando sobre cesariana, violência obstétrica e histerectomia no horizonte da justiça reprodutiva
Authors: Acácia Tempesta Giovana , Lemos Cavalcanti Clarissa , Luciano de França Ruhana 
Published: February 2023

O diálogo entre ciências sociais e ciências da saúde vem produzindo reflexões interessantes a respeito das experiências reprodutivas em diferentes contextos sociais. Várias pesquisadoras demonstraram que essas experiências são influenciadas por matrizes de opressão historicamente constituídas e têm conexão direta com as taxas nacionais de morbidade e mortalidade materna e infantil, as quais evidenciam a perpetuação de hierarquias reprodutivas racializadas, resultantes do processo colonial. Neste artigo, propomo-nos a realizar uma revisão bibliográfica sobre aportes das ciências sociais e dos estudos interseccionais e decoloniais que podem contribuir para aprofundar o debate crítico sobre a apropriação biomédica do ciclo reprodutivo das mulheres, focalizando as duas cirurgias ginecológicas mais realizadas no Brasil, a saber, a cesariana e a histerectomia (remoção do útero), bem como a problemática da violência obstétrica. A presente reflexão se desenrola no horizonte político-epistemológico da justiça reprodutiva, fundamenta-se no conceito de racismo estrutural e aposta na educação perinatal crítica como via estratégica para a superação das iniquidades no campo da reprodução.
Optical Vortices in Random Wavefields
Authors: Freund Issac 
Published: February 2023

Vortices (topological phase singularities), which may be either positive or negative
in sign, are found in many different types of optical fields. On every zero crossing of the real or
imaginary part of the wavefield, adjacent vortices must be of opposite sign. This
new "sign principle", which is unaffected by boundaries, leads to the surprising results that for a
given set of zero crossings: (i) fixing the sign of any given vortex automatically
fixes the signs of all other vortices in the wavefield, (ii) the sign of the
first vortex created during the evolution of a wavefield determines the signs of
all subsequent vortices, and (iii) the sign of this first vortex places additional
strong constraints on the future development of the wavefunction. The sign
principle also constrains how contours of equal phase thread through the wavefield from one vortex
to another.
Amplitude topological (AT) singularities are defined (for the first time) in terms
of the gradient of the field amplitude. Such singularities correspond to stationary points of the
amplitude and are located at the intersections of the zero crossings of the x- and y-partial
derivatives of the amplitude. Amplitude maxima and minima are positive AT
singularities and saddle points are negative AT singularities. The sign principle
implies that adjacent AT singularities on any given zero crossing must be of
opposite sign, that in an unbounded wavefield the total number of maxima and minima must equal the
number of saddle points, that in free space stationary points of the amplitude must
first appear as positive-negative AT singularity twins, and that there must exist strong
correlations between neighboring maxima, minima and saddle points.
The numerous, far reaching implications of the sign principle have been verified using a computer
simulation that generates a random Gaussian wavefield.
Regional variation in knowledge and practice regarding common zoonoses among livestock farmers of selective districts in Nepal
Authors: Bagale Kosh Bilash , Adhikari Ramesh , Acharya Devaraj 
Published: February 2023

Background
The majority of Nepalese people are involved in farming. However, due to limited knowledge of zoonoses and poor preventive practices on the part of livestock farmers, vulnerabilities to zoonotic diseases are very high. The main objective of this study was to assess the regional variation in zoonoses-related knowledge and preventive practices of livestock farmers in different ecological regions of Nepal.

Material and methods
Descriptive cross-sectional quantitative research design was followed in the study. The total sample size was 380 livestock farmers from randomly selected three ecological regions of Nepal. Systematic sampling techniques were applied for data collection. Data were entered into an excel sheet and then imported into Statistical Package for Social Sciences (SPSS) software. The data were calculated using descriptive statistics. Univariate, and bivariate analyses were performed, and the result of the study was presented in the form of text and tables based on their nature.

Results
Of the studied six zoonotic diseases, most of the respondents (95.8%) knew about zoonotic bird flu; 90.7% of them, were about rabies; and 54.2% knew about swine flu. However, a few respondents knew about bovine tuberculosis, neurocysticercosis, and brucellosis. Ecologically, the highest number of respondents in Nawalpur had knowledge of rabies (95.3%), and swine flu (61.6%), whereas 98.3% of them had knowledge of avian influenza in Tanahun; and 12.5% of neurocysticercosis in Manang. Regarding zoonoses preventive practices such as regular hand washing with soap water, mask-wearing, gloves, boots, the respondents’ representation of 60.8%, 6.6%, 1.8%, and 1.3% respectively in such practices show that although these are easy and cost-effective, personal protective equipment (PPE), such preventive practices were extremely underperformed. Not only that, only 12% of respondents maintain a standard distance (>15m.) between their house and shed. Similarly, 17% still consumed meat from sick animals, and vaccination of livestock was also found poor coverage (36%) in the study.

Conclusions
Livestock farmers need to be more knowledgeable about many common zoonotic diseases, and their preventive practices still need improvement, with significant regional variation in the study. This has invited various zoonosis threats for them. Therefore, it is recommended that the interventional programs related to common zoonoses be conducted for livestock farmers to solve the problem.
Prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido-Ekiti, Southwestern Nigeria
Authors: Ibrahim Azeez Oyemomi , Bello Ibrahim Sebutu , Ajetunmobi Adewumi Oluwaserimi , Ayodapo Abayomi , Afolabi Babatunde Adeola , Adeniyi Makinde Adebayo 
Published: February 2023

Background
Asymptomatic malaria infections have received less attention than symptomatic malaria infections in major studies. Few epidemiological studies on asymptomatic malaria infections have often focused on pregnant women and children under-five years of age as the most vulnerable groups. However, there is limitation on data regarding asymptomatic infections among the old adult populations, particularly in the study area. Therefore, this study determined the prevalence of asymptomatic malaria infection by microscopy and its determinants among residents of Ido- Ekiti, Southwestern Nigeria.

Methods
A hospital-based cross-sectional study was conducted between July and September 2021 among 232 consenting apparently healthy individuals aged 40 years and above who were recruited during a free health screening program using a standardised interviewer-administered questionnaire. The questionnaire sought information on respondents’ socio-demographics, presence and types of co-morbidity, and the prevention methods being adopted against malaria infection. Venous blood samples were collected and processed for asymptomatic infections using Giemsa-stained blood smear microscopy. Data were analysed using SPSS version 21. Multivariate logistic regression was used to identify factors associated with asymptomatic infections.

Results
Of the total 232 respondents, 19.0% (48/232) were confirmed to be infected with Plasmodium falciparum (95% confidence interval (CI): 14.1% - 24.6%). Lack of formal education (Adjusted odds ratio (AOR): 5.298, 95% (CI): 2.184-13.997), being diabetic (AOR: 4.681, 95% CI: 1.669-16.105), and not sleeping under Long Lasting Insecticide Net (LLINs) (AOR: 4.594, 95% CI: 1.194-14.091), were the determinants of asymptomatic Plasmodium falciparum infection.

Conclusion
The prevalence of asymptomatic Plasmodium falciparum was 19%. Lack of formal education, being diabetic, and not sleeping under LLINs were the determinants of asymptomatic infections.
Development of a data platform for monitoring personal health records in Japan: The Sustaining Health by Integrating Next-generation Ecosystems (SHINE) Study
Authors: Fukuda Haruhisa , Murata Fumiko , Azuma Sachie , Fujimoto Masahiro , Kudo Shoma , Kobayashi Yoshiyuki , Saho Kenshi , Nakahara Kazumi , Ono Rei 
Published: February 2023

Background
The Sustaining Health by Integrating Next-generation Ecosystems (SHINE) Study was developed as a data platform that incorporates personal health records (PHRs) into health-related data at the municipal level in Japan. This platform allows analyses of the associations between PHRs and future health statuses, and supports the production of evidence for developing preventive care interventions. Herein, we introduce the SHINE Study’s profile and describe its use in preliminary analyses.

Methods
The SHINE Study involves the collection of participants’ health measurements and their addition to various health-related data from the Longevity Improvement & Fair Evidence (LIFE) Study. With cooperation from municipal governments, measurements can be acquired from persons enrolled in government-led long-term care prevention classes and health checkups who consent to participate in the SHINE Study. For preliminary analyses, we collected salivary test measurements, lifelog measurements, and gait measurements; these were linked with the LIFE Study’s database. We analyzed the correlations between these measurements and the previous year’s health care expenditures.

Results
We successfully linked PHR data of 33 participants for salivary test measurements, 44 participants for lifelog measurements, and 32 participants for gait measurements. Only mean torso speed in the gait measurements was significantly correlated with health care expenditures (r = -0.387, P = 0.029).

Conclusion
The SHINE Study was developed as a data platform to collect and link PHRs with the LIFE Study’s database. The analyses undertaken with this platform are expected to contribute to the development of preventive care tools and promote health in Japan.
Towards an extended notion of Common Ground in aphasiology
Authors: Graci Roberto 
Published: February 2023

Abstract
This article aims to analyze the evolution of the Common Ground notion in theoretical and sociocognitive fields. Some recent studies from psychology, cognitive sciences, and socio-linguistics have enriched the traditional formulations on CG by analyzing various factors related to the nature of mental processes. It emerged that CG is a dynamic entity where sources of different nature interact in a complex way during the communication process. On the other hand, contemporary clinical investigations on CG and aphasia seem to overlook the multiple and dynamic factors involved in the communication between patients and ordinary speakers. Although most experimental studies prove that any form of knowledge can, in principle, support communication with aphasic patients, it seems that they focus their attention only on an isolated aspect of the situational or past context. A general theory that explains how personal, cultural, or perceptual knowledge jointly mediates the understanding of texts produced by aphasic patients is missing. This work does not intend to offer such a theory. Instead, it has the less ambitious purpose of highlighting the current limitations related to the practice of breaking down and analyzing isolated features of the CG. Highlighting these limitations is essential in pushing aphasiology research towards introducing more complex models of CG adhering to the reality of the facts.
A Dialogized Monologue: A Study of Gu Hongming’s Letters to Richard Wilhelm
Authors: Wu Siyuan 
Published: February 2023

Abstract
This paper examines the twenty-one letters from a Chinese scholar Gu Hongming to a German Sinologist Richard Wilhelm. It is essential to empower the right of speech on the side of Wilhelm by restoring a dialogic discourse from the epistolary space and revealing the innate nature of polemic in Gu’s internally dialogized publications. Their interconnected cultural and social activities represented in these letters may all be regarded as concrete rejoinders that signify their meanings and are signified by their previous context. The interaction between Gu and Wilhelm has cast a far-reaching impact on their developments in either academic thoughts or cultural identities, so much so that only by perceiving their reciprocally infiltrated ideas and related activities in coexistence are we able to understand their richer and fuller personalities developing along a mutual reference line and in a context of an unfinalized dialogue.
Relay fusion frames in Banach spaces
Authors: Hong Guoqing , Li Pengtong 
Published: February 2023

Abstract
The relay fusion frames have been recently introduced in Hilbert spaces to model sensor relay networks and distributed sensor relay systems, which are deeply connected with compressed sensing. In this article, we introduce the notions of relay fusion frames and Banach relay fusion frames in Banach spaces and study certain attractive properties of relay fusion frames in this more general setting. In a particular sense, Schauder frames can be shown to be a special case of relay fusion frames. Moreover, the stability issue of relay fusion frames and Banach relay fusion frames will be addressed.
On the uniqueness of limit cycles for generalized Liénard systems
Authors: Zhou Hui , Yuan Yueding 
Published: February 2023

Abstract
In this article, the general Liénard system

d
x

d
t

=
ϕ

(

y

)

−
F

(

x

)

,

d
y

d
t

=
−
g

(

x

)

\left\{\begin{array}{l}\frac{{\rm{d}}x}{{\rm{d}}t}=\phi (y)-F\left(x),\\ \frac{{\rm{d}}y}{{\rm{d}}t}=-g\left(x)\end{array}\right.

is studied. By using the Filippov transformation, combined with the careful estimation of divergence along the closed orbit, we prove the sufficient conditions for the uniqueness of limit cycles in this system. Our results extend almost all the related existing studies on the Liénard system.
The crystal structure of 1-((1-methyl-1H-1,2,4-triazol-3-yl) methyl)-3-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4,6-trione, C14H11F3N6O3
Authors: Du Yi-Jing , Sun Hong-Shun , Wang Jian-Qiang , Xu Jia-Ying 
Published: February 2023

Abstract
C14H11F3N6O3, orthorhombic, Pbca (no. 61), a = 8.08620(10) Å, b = 15.4730(2) Å, c = 23.5892(2) Å, V = 2951.43(6) Å3, Z = 8, R

gt
(F) = 0.0463, wR

ref
(F
2) = 0.1395, T = 293 K.
Die Geteiltheit virtueller Situationen
Authors: Roth Philip , Laut Christina 
Published: February 2023

Zusammenfassung
Kommunikation ist das Rückgrat vieler organisationaler Prozesse. Gegenwärtig findet eine zunehmende Virtualisierung dieser Kommunikationsprozesse statt. In der bisherigen Forschung dazu wurde primär auf virtuelle Kommunikationskanäle fokussiert. Soziologische Kommunikationstheorien unterstreichen jedoch, dass Kommunikation durch geteilte Situationsdefinitionen gerahmt wird. Da diese Theorien aber von leibhaftiger Kopräsenz ausgehen, ist unklar, inwiefern soziale Situationen auch virtuell geteilt werden. In unserem Beitrag zeigen wir im systematischen Vergleich von face-to-face Kommunikation und softwaregestützter Videotelefonie, welche Aspekte von Situationen unter den jeweiligen Kommunikationsbedingungen geteilt werden und wie sich die jeweilige Situiertheit auf Kommunikation auswirkt. Diese Analyse macht deutlich, wie eine zunehmende Virtualisierung besonders relevante Formen organisationaler Kommunikation verändert. Der Beitrag trägt somit dazu bei, das soziologische Konzept der sozialen Situation für virtuelle Situationen zu öffnen.
Government Intervention and the Improvement of Competitiveness of the National Coffee Industry: The Case of Indonesian Gayo Coffee
Authors: Luneto Riska 
Published: February 2023

This article analyses the Indonesian government's intervention to increase the competitiveness of its national coffee industry, especially one of its speciality coffees known as Gayo coffee. It aims to describe the value of Gayo coffee competitiveness based on the level of production, export volume and income of coffee farmers. In doing so, this study used Michael Porter's competitive advantage analysis which is known as the diamond model concept. The findings show that the four indicators in the diamond model concept cannot be fulfilled to make Gayo coffee a product that has competitive advantages for the government intervention was not sufficient in improving the good climate of the Gayo coffee industry. Stakeholders' cooperation in the coffee industry is needed to improve or continue the government efforts so that the Indonesian coffee industry can be competitive with the ones from other countries.