bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential vs Myeloablative vs Reduced Intensity Conditioning for Patients with Myelodysplastic Syndromes with an excess of blasts at time of allogeneic haematopoietic cell transplantation: A Retrospective Study by the Chronic Malignancies Working Party of the EBMT
Authors: Potter Victoria , Gras Luuk , Biezen Anja van , Kroeger Nicolaus , Sockel Katja , Ganser Arnold , Finke Jürgen , labussiere helene , de Latour Regis Peffault , Koc Yener , Friis Lone , Salmenniemi Urpu , Jindra Pavel , Schroeder Thomas , Tischer Johanna , Arat Mutlu , Pascual María , de Wreede Liesbeth , Hayden Patrick , Raj Kavita , Drozd-solowska Joanna , Scheid Christof , McLornan Donal , Robin Marie , Yakoub-Agha Ibrahim 
Published: March 2023

Abstract
The optimal conditioning for patients with higher risk MDS receiving potentially curative allogeneic haematopoietic stem cell transplant(allo-HCT) remains to be defined. This is particularly the case for patients with excess of blasts at time of allo-HCT. Sequential(Seq) conditioning, whereby chemotherapy is followed rapidly by transplant conditioning, offers an opportunity to decrease disease burden, potentially improving outcomes allo-HCT outcomes. Herein we present the only analysis comparing Seq to myeloablative(MAC) and reduced intensity conditioning(RIC) specifically focussed on MDS patients with excess of blasts at allo-HCT. 303 patients were identified in the EBMT registry, receiving RIC(n=158,) Seq(n=105,), and MAC(n=40, ). Median follow-up was 67.2 months and median age at allo-HCT was 59.5 years(IQR 53.5 - 65.6). For the entire cohort, 3yr overall survival(OS) was 50%(95% CI45-56%) and relapse free survival(RFS) 45%(95%CI 40-51%). No differences in outcomes were observed per protocol with respect to OS and RFS. On multivariable analysis, lower performance status, worse IPSS-R cytogenetics, sibling donor (compared to 8/8 MUD) and >20% blasts at allo-HCT were associated with worse outcomes. In conclusion, the Seq protocol did little to influence the outcome in this high-risk group of patients, with outcomes mostly determined by baseline disease risk and patient characteristics such as performance status.
Clinical features and treatment outcomes of a patient with retinitis pigmentosa secondary to adult coats' disease
Authors: Fu Wenzhong , Xu Hongxia , Ma Yujun , Jiang Huaiyan 
Published: March 2023

Abstract
Retinitis pigmentosa(RP) is a set of hereditary retinal diseases. We describe a patient who suffered retinitis pigmentosa secondary to adult coats' disease. The patient had undergone pars plana vitrectomy(PPV),intravitreal injection of anti-VEGF drugs as well as steroids. Eventually, the patient had a good anatomical result postoperatively.
Accuracy of Fit for Cobalt-Chromium Bar Over Two Implants Fabricted with Different Manufacturing Techniques‑An in Vitro Study.
Authors: Nassar Hossam I , Fateen Ayman 
Published: March 2023

Abstract
Objective
The purpose of the invitro research was to compare the fit of Cobalt Chromium customized bar fabricated with different manufacturing processes cast metal bar, milled bar and 3D printed bar using scanning electron microscope.
Material and Methods
Clear epoxy resin molds were prepared. In each mold two parallel implants with a 14 mm distance from each other were embedded. Thirty Co-Cr custom bars were constructed and were divided equally into three groups: Group (I) (Co-Cr conv), group (II) milled bar (Co-Cr milled), and group (III) printed bar (Co-Cr print). The marginal fit at implant-abutment interface was scanned using scanning electron microscope (SEM)
Results
There was a significant difference between the three studied groups regarding marginal misfit the between implant and fabricated bars with p-value < 0.001. The highest value of micro-gap distance was found in Co-Cr conventional group (7.95 ± 2.21µm) followed by Co-Cr 3D printed group (4.98 ± 1.73) and the lower value were found in Co-Cr milled (3.22 ± 0.75).
Conclusion
The marginal fit of milled, 3D printed and conventional cast for Co-Cr alloy were within the clinically acceptable range of misfit. CAD/CAM milled Co-Cr bar revealed a superior internal fit at the implant-abutment interface. This was followed by selective laser melting (SLM) 3D printed bar and the least fit was shown for customized bar with the conventional lost wax technique.
Technology Based Supportive Care for Metastatic Breast Cancer Patients
Authors: Schmitz Kathryn H. , Kanski Beth , Gordon Brett , Caru Maxime , Vasakar Monali , Truica Cristina I. , Wang Ming , Doerksen Shawna , Lorenzo Abby , Winkels Renata , Qui Ling , Abdhullah Saeed 
Published: March 2023

AbstractPurposeMetastatic breast cancer (MBC) patients are living longer. However, symptom burden remains a significant issue. Technology-based interventions may be a solution. The purpose of this study was to test a virtual assistant for addressing symptoms in MBC using the Amazon Echo Show with Alexa.MethodsIn this partial crossover randomized trial, the immediate treatment group was exposed to the intervention, called Nurse AMIE (Addressing Metastatic Individuals Everyday) for six months. The comparison group was unexposed for the first 3 months, then exposed for 3 months. The randomized controlled trial (RCT) during the first 3 months allowed for evaluation of intervention effects on symptoms and function. The partial crossover maximized exposure to the intervention for evaluation of feasibility, usability, and satisfaction. RCT outcome data were collected at baseline and 3 months. Feasibility, usability, and satisfaction data were collected throughout the first 3 months of intervention exposure.ResultsForty-two MBC patients were randomized (1:1). Participants were 53±11 years old and 4±7 years from diagnosis with metastatic disease. No significant effects on psychosocial distress, pain, sleep disturbance, fatigue (vitality), quality of life, or chair stands were noted, despite high levels of acceptability (51%), feasibility (65%), and satisfaction (70%).ConclusionA high level of participant acceptability, feasibility, usability, and satisfaction all suggest further research on this platform is warranted. The lack of statistically significant effects on symptoms, quality of life, and function may be the result of small sample size. Clinical Trials.gov Registration number: NCT04673019; Registration date: December 17, 2020
Unravelling the effects of active site densities and energetics on the water oxidation activity of iridium oxides
Authors: Liang Caiwu , Rao Reshma , Svane Karine , Hadden Joseph , Moss Benjamin , Scott Soren , Sachs Michael , Murawski James , Frandsen Adrian , Riley Jason , Ryan Mary , Durrant James , Rossmeisl Jan , Stephens Ifan 
Published: March 2023

Abstract

Understanding what controls the reaction rate on iridium-based catalysts is central to designing more active and stable electrocatalysts for the water oxidation reaction in proton exchange membrane (PEM) electrolysers. Here, we quantify the densities of redox active centres and probe their binding strengths on amorphous IrOx and rutile IrO2 using a combination of operando time-resolved optical spectroscopy, X-ray absorption spectroscopy (XAS) and time of flight secondary ion mass spectrometry (TOF-SIMs). Firstly, our results show that although IrOx exhibits an order of magnitude higher geometry current density compared to IrO2, the intrinsic rates of reaction per active state, on IrOx and IrO2 are comparable at a given potential. Secondly, we establish a quantitative experimental correlation between the intrinsic rate of water oxidation and the energetics of the active states. We use density functional theory (DFT) based models to provide a molecular scale interpretation of our data. We find that the *O species formed at water oxidation potentials have repulsive adsorbate-adsorbate interactions, and thus increasing their coverage weakens their binding and promotes the rate-determining O-O bond formation. Finally, we provide insights into how the intrinsic water oxidation kinetics can be increased by optimising both the binding energy and the interaction strength of the catalytically active states.
Analysis of the disease entities and typical characteristics of day surgery -based on three Public Tertiary A hospitals in China
Authors: wang ying , sun hui 
Published: March 2023

Abstract
Background: Although the number of medical facilities in China that perform day surgeries is rapidly rising, little research has been done on the current state of day surgery performance and patient distribution. This thesis focuses on three more developed tertiary general hospitals in different parts of China where day surgery has been performed in the past. These hospitals offer a wider variety of day surgery procedures, and are located in areas that are more developed. Other medical facilities will benefit from the study's hands-on experience with day surgery.
Methods: 67,337 valid items of data were retrieved from Hospital Information Systems of the three hospitals. In this thesis, descriptive analysis was carried out on basic information about day surgery patients, including composition of patients' major diseases, hospitalization costs. Nonparametric tests were used to compare the data in each group, and the mean standard deviation (x±s) was used to show the trend in the concentration of the relevant indicators. The difference was considered statistically significant at P<0.05.
Results: The largest proportion of day surgery patients are between the ages of 51 and 70. About 57.30% of day surgery patients pay for their medical care with the basic medical insurance of urban employees. Senile cataract, benign breast tumor, and endometrial polyp are the top three major diagnoses of day surgery patients. The cost of consumables accounted for approximately 46.01 percent of the total hospitalization cost for day surgery patients, followed by the cost of treatment, which accounted for approximately 31.01 percent of the total cost.
Conclusions: The majority of day surgery patients are middle-aged and elderly, with fewer children and seniors over 80. The payment system for day surgery that is supported by medical insurance needs to be improved. While each hospital has its own characteristics, the majority of day surgery patients are afflicted with ophthalmic, breast, and reproductive system conditions. The majority of day surgery procedures are secondary and tertiary procedures; the more challenging procedures continue to be primarily general inpatient procedures. Day surgery's development has positive effects on society and the economy.
Health literacy strengths and challenges of people in New South Wales Prisons: A cross-sectional survey using the Health Literacy Questionnaire (HLQ)
Authors: Gill Scott W , Zeki Reem , Kaye Sharlene , Zingirlis Panayiota , Archer Vicki , Lewandowski Amy , Creighton Grantley , Shaw Caron , Bowman Julia 
Published: March 2023

Abstract
Background: Health literacy is an important factor for enabling people to manage their health and live long fulfilling lives. People in prison are frequently from marginalised communities, often out of reach of conventional community based health organisations, and have poorer health outcomes. It is essential to understanding the health literacy profiles of people in prison, and its contribution to the well-established health inequities and outcomes of this population. This study aimed to use a multi-dimensional health literacy measurement tool to describe the strengths and challenges of adults incarcerated in NSW prisons.
Methods: A cross-sectional survey was conducted for people in prison across 14 publicly operated metropolitan prisons. Data were collected from 471 participants using the Health Literacy Questionnaire (HLQ). Participant characteristics and health conditions were also collected. Data were analysed using descriptive statistics. Effect sizes (ES) for standardised differences in means were used to describe the magnitude of difference between participant characteristic groups.
Results: Participants’ median age was 38.0 (range 19 – 91) years. Males comprised 81% of the sample, 21% identified as Aboriginal and/or Torres Strait Islander, and 53% reported a health problem. People in prison had lower scores for all nine HLQ scales when compared to the general Australian population. Small to medium ES were seen for mean differences between most demographic groups. Compared to males, females had lower scores for a majority of the HLQ scales including ‘having sufficient information to manage health’ (ES 0.30 [95% Confidence Interval (CI) 0.07, 0.53]), ‘ability to actively engage with health care professionals’ (ES 0.30 [95% CI 0.06, 0.53]), ‘navigating the healthcare system’ (ES 0.30 [95% CI 0.06, 0.53]), and, ‘ability to find good health information’ (ES 0.33 [95% CI 0.10, 0.57]). Differing health literacy scale scores with small to medium ES were found when comparing participants by legal status. Mainly small ES were seen when comparing other participant characteristic groups.
Conclusions: This study provides insights into the health literacy strengths and challenges for people in NSW prisons. These findings highlight the important role health literacy could have in addressing health disparities in this vulnerable population and can inform prison health services.
Beneficial glycaemic effects of barley bread compared to wheat bread in type 2 diabetes
Authors: Bohl Mette , Gregersen Soeren , Zhong Yuyue , Hebelstrup Kim , Hermansen Kjeld 
Published: March 2023

Abstract
Background:
Cereals foods with a high content of dietary fibres or amylose have potential to lower postprandial glucose levels. Optimisation of cereal foods may delay development of or improve management of type 2 diabetes (T2D).
Methods:
We investigated the impact on postprandial glucose metabolism of bread made of hulless barley flour (50% or 75%) and wheat flour (50% or 25%) or an RNAi-based amylose-only barley flour (AmOn) (50%) and wheat flour (50%) in subjects with T2D.
Design:
Twenty adults with T2D were randomly allocated to one of four bread each corresponding to 50 g carbohydrate at four separate visits. We measured fasting and 4h postprandial responses of glucose, insulin, glucagon, triacylglycerol, free fatty acids, glucagon-like peptide-1 and gastric inhibitory polypeptide. Mixed model ANOVA was used to examine the differences.
Results:
Bread made from 50% AmOn lowered the postprandial glucose by 34%, 27%, 23% (P < 0.05) compared with 100% wheat, 50% or 75% hulless barley, respectively. Bread made from 75% hulless barley reduced the postprandial glucose by 11% (P < 0.05) compared to 100% wheat bread.
Postprandial insulin responses were reduced for 50% AmOn by 24% and 35% (P < 0.05) compared with 100% wheat and 50% hulless barley, respectively. Postprandial insulin was reduced by 22% (P < 0.05) for 75% compared to 50% hulless barley bread.
Conclusions:
Bread made by replacing wheat flour with either 75% hulless barley or 50% AmOn flour lowered postprandial glucose responses compared to 100% wheat bread indicating a beneficial impact in management of T2D.
This trial was registered at clinicaltrials.gov as NCT04646746.
The associations between cardiometabolic index and non-alcoholic fatty liver disease
Authors: Xue Feiben , Zhang Shengguo , He Lingnan , Yang Naibin , Chen Yuanwen 
Published: March 2023

Abstract
Object: To explore the association between cardiometabolic index(CMI) and non-alcoholic fatty liver disease (NAFLD) detected by Fibroscan in Americans.
Methods: A total of 2054 participants from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 were included in this cross-sectional analysis. The diagnosis of NAFLD was based on the following criteria: controlled attenuation parameter(CAP) value≥274 dB/m indicating liver steatosis and exclusion of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and excessive alcohol consumption. The relationship between CMI and NAFLD was assessed using a weighted multivariable logistic regression. Subgroup analyses stratified by gender, race, and BMI were further conducted.
Results: A total of 796 (38.8%) participants were confirmed with NAFLD. CMI was significantly higher in NAFLD group than that in non-NAFLD group (P<0.001). In all the three regression models, CMI were positively associated with the prevalence of NAFLD (model 1: OR=6.76, 95% CI: 5.27 to 8.68; model 2: OR=5.54, 95% CI: 4.30 to 7.14; model 3: OR=2.13, 95% CI: 1.65 to 2.76). After stratified by gender, race and BMI, the positive correlations existed steadily in different subgroups. The smooth curve fit showed an inverted U-shaped association between CMI and the prevalence of NAFLD.
Conclusion: CMI was positively correlated with the prevalence of NAFLD in the general American population. Moreover, the positive relationship between CMI and NAFLD existed steadily after stratified by gender, race, and BMI.
Sulfonic-coordinated Co–N–C solid acid catalysts for high-performance solvent regeneration for efficient carbon capture
Authors: Li Yuchen , Yuan Bingling , Xing Lei , Zhan Guoxiong , chen zhen , Peng Yue , Wang Lidong , li Junhua 
Published: March 2023

Abstract
Atomically dispersed Co–N–C coordination is a promising strategy for providing acidic activity sites for catalytic amine solvent regeneration, but the control of the coordination environment remains a major challenge. Herein, the sulfo group (-SO3H) introduced to improve the Co–N–C coordination and morphology of COF supports. The new coordination configuration (Co–N/C/O) significantly increased the acidic activity of the COF catalysts with single-atom Co and promote the surface areas (696 m2/g). The sulfonic-coordinated Co–N–C (S–Co/NC) catalysts exhibited superior spent solvent regeneration activity at lower concentrations compared with previously described catalysts. Moreover, the maximum desorption rate (3.74 CO2 mmol/min) considerably increased by 733% compared with the catalyst-free reaction, resulting in approximately 39% lower relative heat duty. This study presented an efficient and feasible method for atomic-level tuning of the Co–N–C catalyst for developing excellent solid acid catalysts for energy-efficient amine solvent regeneration.
Dengue virus infection during window period of consecutive outbreaks in Nepal and assessment of clinical parameters
Authors: Rauniyar Ramanuj , Prajapati Sabita , Manandhar Binod , Bastola Anup , Chalise Bimal Sharma , Shrestha Srijan , Khanal Chetana , Thapa Machchhendra , Napit Rajindra , Adhikari Anurag , Manandhar Krishna Das 
Published: March 2023

Abstract
Nepal is an endemic country for dengue infection with rolling of every three year’s clear cyclic outbreaks with exponential growth since 2019 outbreak and the virus gearing towards the non-foci temperate hill regions. However, the information regarding circulating serotype and genotype is not frequent. This research discusses on the clinical features, diagnosis, epidemiology, circulating serotype and genotype among 61 dengue suspected cases from different hospitals of Nepal during the window period 2017–2018 between the two outbreaks 2016 and the then expected 2019 outbreak along with the challenges of DENV infection in Nepal. E-gene sequences from PCR positive samples were subjected to phylogenetic analysis under time to most recent common ancestor tree using Markov Chain Monte Carlo (MCMC) and BEAST v2.5.1. Both evolution and genotypes were determined based on the phylogenetic tree. Serotyping by Real-time PCR and Nested PCR showed the co-circulation of all the 3 serotypes of dengue in the year 2017 and DENV-2 in 2018. Genotype V for DENV-1 and Cosmopolitan Genotype IVa for DENV-2 were detected. The detected Genotype V of DENV-1 in Terai was found close to Indian genotype while Cosmopolitan IVa of DENV-2 found spreading to geographically safe hilly region (now gripped to 9 districts) was close to South-East Asia. The genetic drift of DENV-2 is probably due to climate change and rapid viral evolution which could be a representative model for high altitude shift of the infection. Further, the increased primary infection indicates dengue venturing to new populations. Platelets count together with Aspartate transaminase and Aalanine transaminase could serve as important clinical markers to support clinical diagnosis. The study will support future dengue virology and epidemiology in Nepal.
The novel oncogenic factor TET3 combined AHR to promote Thyroid cancer lymphangiogenesis via HIF-1α/VEGF signaling pathway
Authors: YANG Li-Yun , Zhao Runyu , Qiao Peipei , Cui Jiaxin , Chen Xiaoping , Fang Jinping , Hu An , Huang Shuixian 
Published: March 2023

Abstract
Background
Lymphangiogenesis is an important factor in the invasion and metastasis of thyroid cancer (THCA). The relative researches of lymphangiogenesis have always been a hot topic in THCA, but its specific regulatory mechanism has not been totally clear.
Methods
Public databases including the Cancer Genome Atlas (TCGA), TIMER, GEPIA, and UALCAN database were employed to analyze and visualize the expression and prognosis of TET3 and AHR in THCA. GEPIA and TIMER were used to analyze the correlation between these molecules. Rt-PCR and Western Blot were used to detect the mRNA and protein expression of related proteins. Plate colony formation, cycle, apoptosis, angiogenesis and transwell assay were used to examine the ability of proliferation, lymphangiogenesis and invasion of THCA cells.
Results
TCGA database were showed that TET3 and AHR in tumor tissue compared to normal tissue in THCA. And there was a high correlation between TET3 and AHR. UALCAN and GEPIA database were exhibited that high expression of TET3 and AHR were corelated with THCA TNM stages and poor prognosis of THCA patients. Moreover, the TET3 activation accelerated THCA cells proliferation by inducing G2/M phase arrest and restraining apoptosis, and the AHR inactivation reduced THCA cells proliferation by decreasing G2/M phase arrest and inducing apoptosis in vitro of THCA cells. Notably, TET3 and AHR markedly promoted THCA cells lymphangiogenesis and invasion. In addition, TET3 activation and AHR inactivation regulated HIF-1α/VEGF signaling pathway.
Conclusions
TET3 combined AHR to promote THCA lymphangiogenesis via HIF-1α/VEGF signaling pathway and targeting TET3 and AHR might provide a potential treatment strategy for THCA.
Real-time detection of label-free submicron-sized plastics using flow-channeled differential interference contrast microscopy
Authors: Kim Jae Hun , Han Jiyun , Park Subeen , Seid Mingizem Gashaw , Park Byeongho , Lee Soo Hyun , Kim Hyung Min , Lee Jaesang , Hong Seok Won 
Published: March 2023

Abstract
Owing to the surge in plastic waste generated during the COVID-19 pandemic, concern regarding microplastic pollution in aqueous environments is increasing. Since sub-micron plastics can accumulate in the human body, their real-time detection in water is necessary. However, the decrease in the scattering cross-section of small polystyrene (PS) particles in aqueous media precludes detection by bright-field microscopy. To address this problem, we propose and demonstrate a differential interference contrast (DIC) system that incorporates a magnification-enhancing system to detect PS beads in aqueous samples. To detect micron-scale and sub-micron-scale PS beads in the stationary and mobile phases, a microfluidic chip was designed considering the imaging depth of focus and flow resistance. PS beads of various sizes flowing in deionized and tap water at varying speeds were quantitatively observed under Static and Flow conditions. The real-time detection and quantification of PS beads of size ≥ 200 nm at a constant flow rate in water was successful. It was also possible to classify two different sizes, 2 µm and 750 nm, in a mixed solution. Thus, the proposed novel method can significantly reduce the analysis time and improve the size-detection limit. The proposed DIC microscopy system can be coupled with Raman or IR spectroscopy in future study for chemical composition analysis.