bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing laser brightness in a rare-earth-free system
Authors: Fan Chenchen , hao xiulu , Yao Tianfu , Wu Jian , Leng Jinyong , Zhou Pu 
Published: August 2023

Abstract
Multimode fibers, which support a complex mix of spatial and temporal nonlinear phenomena, have recently reemerged as a viable experimental platform for studying intricate physical processes. Additionally, their high-power handling abilities enable them widely used in applications beyond telecommunications. Within this research paper, we conducted a comprehensive theoretical analysis of the nonlinear dynamics involved in the process of Kerr effect-enhanced beam cleanup during stimulated Raman scattering in multimode graded-index fibers. Leveraging this nonlinear dynamic, and spectral synthesis technology to enhance the pump brightness, high-brightness radiation with previously unprecedented power is experimentally generated in a rare-earth-free and purely passive fiber-based system. This experimental achievement serves as compelling evidence for the immense capability of the localized Kerr effect-enhanced Raman beam cleaning as a highly efficient brightness converter. And this extraordinary contribution unveils invaluable and revolutionary insights that forge an entirely new frontier in the realm of laser design, delivering an unprecedented vantage point that transcends conventional boundaries. © The Author(s) 2023
Development of a Novel Electronic Record System for Documentation and Efficient Workflow for Community Health Workers
Authors: Acharya Harshdeep , Sykes Kevin J. , Neira Ton Mirás , Scott Angela , Pacheco Christina M. , Sanner Matthew , Ablah Elizabeth A. , Oyowe Kevin , Ellerbeck Edward F. , Greiner K. Allen , Corriveau Erin A. , Finocchario-Kessler Sarah 
Published: August 2023

Abstract

Community health workers (CHWs) can be a crucial extension of public health resources to address health inequities, but systems to document CHW efforts are often fragmented and prone to unneeded redundancy, errors, and inefficiency. We sought to develop a more efficient data collection system for recording the wide range of community-based efforts performed by CHWs. The Communities Organizing to Promote Equity (COPE) project is an initiative to address health disparities across Kansas, in part, through the deployment of CHWs. Our team iteratively designed and refined the features of a novel data collection systems for CHWs. Pilot tests with CHWs occurred over several months to ensure the functionality supported their daily use and to identify areas for improvement. At launch, the database had 60 active users in 20 counties. To our knowledge, this is one of the first single-platform systems allowing for the collection of information about partner organizations, community outreach events, client encounters, and progress toward client's goals. Documented client interactions begin with needs assessments (modified versions of the Arizona Self-sufficiency Matrix and PRAPARE) and continue with longitudinal tracking of progress toward goals. A user-specific automated alerts-based dashboard displays clients needing follow-up and upcoming events. Our database extends beyond conventional electronic medical records and provides flexibility for ever-changing needs. The COPE Database provides real-world data on CHW accomplishments, improving the uniformity of data collection to enhance monitoring and evaluation. This database can serve as a model for community-based documentation systems and be adapted for use in other community settings.
Adverse events profiles of liposomal and conventional doxorubicins: An updated comprehensive analysis of the FDA adverse event reporting system
Authors: Li Zhengjun , Su Huiling , Jia Jing , Mao Yuxiang , Zhu Riran 
Published: August 2023

Abstract
The clinical application of doxorubicin (DOX) is constrained by its side effects. Liposomal doxorubicin was developed to mitigate these limitations, showing improved toxicity profiles. However, the adverse events associated with liposomal doxorubicin and CDOX have not yet been comprehensively evaluated in clinical settings. The FAERS data from January 2004 to December 2022 were collected to analyze the adverse events of liposomal DOX and CDOX. Disproportionate analysis and Bayesian analysis were employed to quantify this association. Our analysis incorporated 68,803 adverse event reports related to liposomal doxorubicin and CDOX. The relative odds ratios (RORs, 95%CI) for febrile neutropenia associated with CDOX, Doxil®/Caelyx®, and Myocet® were 42.45(41.44;43.48), 17.53(16.02;19.20), and 34.68(26.63;45.15) respectively. For cardiotoxicity, they were 38.87(36.41;41.49), 17.96(14.10;22.86), and 37.36(19.34;72.17). For Palmar-Plantar Erythrodysesthesia (PPE), the RORs were 6.16(5.69;6.68), 36.13(32.60;40.06), and 19.69(11.59;33.44). Regarding onset time, significant differences adverse events including neutropenia, PPE, pneumonia and malignant neoplasm progression. This study indicates that the use of CDOX warrants careful monitoring for cardiotoxicity, PPE, and interstitial lung disease, especially with Doxil®. Additionally, the onset time of febrile neutropenia, malignant neoplasm progression, and pneumonia associated with liposomal doxorubicin merits particular attention. Continuous surveillance, risk evaluations, and additional comparative studies between liposomal doxorubicin and CDOX are recommended.
Genomic characteristics and comparative analysis of chloroplast genome in Magnoliaceae
Authors: Ma Fei , Fu Chun 
Published: August 2023

Abstract
Magnoliaceae is a relatively primitive angiosperm, which is of great significance for the study of long chain of biological evolution. In this study, the chloroplast genome of Magnoliaceae was analyzed, and the codon usage pattern preference of Magnoliaceae chloroplast genome was analyzed by CondonW1.4.2 and EMBOSS. The chloroplast genome content of 63 Magnoliaceae plants was lower than 50%, and the NC value was higher than 35, indicating that the chloroplast genome codon use was weak. Based on the analysis of ENC-plot, it is indicated that the main factor affecting the use bias of chloroplast genome codon in Magnoliaceae is the influence of base mutation. There is A preference for A or T in the use of codons. The analysis of the genome structure of Magnoliaceae showed that Magnoliaceae has a typical four-segment ring structure of angiosperms, including a single copy region, a large copy region and a reverse repeat region, and the IR region of Magnoliaceae chloroplast genome showed a non-significant expansion trend. In this study, the chloroplast genome structure and codon preference of Magnoliaceae were analyzed to provide scientific basis for the accurate identification of species and germplasm resources of Magnoliaceae. The phylogenetic tree of 63 species of Magnoliaceae was established by using the maximum likelihood method to explore the phylogenetic relationships among species, and to provide scientific basis for further research on the phylogenetic relationships of Magnoliaceae.
Autologous Stem Cell Transplant Followed by Two Years of Post-transplant Therapy for Older Patients With Multiple Myeloma: A Prospective Phase II Trial
Authors: Strouse Christopher , Mott Sarah , Smith Brian , Magalhaes-Silverman Margarida , Farooq Umar , Zhan Fenghuang , Jethava Yogesh , Tricot Guido 
Published: August 2023

Abstract
High dose melphalan and hematopoietic stem cell transplantation (HSCT) is a standard treatment for eligible patients with multiple myeloma (MM). Intensified transplant regimens, if safe, may improve patient outcomes. Thus, we evaluated the safety and efficacy of intensified conditioning with HSCT followed by a two-year triple agent maintenance in patients aged ≥65 with recently diagnosed multiple myeloma MM.

The induction therapy was dexamethasone, cisplatin, doxorubicin, cyclophosphamide, and etoposide infusion. This was followed by conditioning with bortezomib, thalidomide, dexamethasone and high dose melphalan with HSCT. Post-transplant maintenance was given for 24 months, consisting of cycles of bortezomib, thalidomide, and dexamethasone followed by cycles of bortezomib, cyclophosphamide, and dexamethasone.

We enrolled 41 patients. Median age was 68 years. The best overall response was stringent complete response (sCR) in 85% of patients. The median progression-free survival (PFS) was 76.4 months. The 48-month PFS and overall survival rates were 64% and 83%, respectively. One patient died from transplant related toxicity (2.4%).

The high rate of CR, favorable median PFS, and good safety profile demonstrate the feasibility and efficacy of this regimen in older transplant-eligible patients. The study highlights that HSCT should be entertained and is probably the treatment of choice in eligible patients.
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors
Authors: Landén Ning Xu , Piipponen Minna , Bian Xiaowei , Liu Zhuang , Sangsuwan Traimate , Maselli Monica , Diaz Candice , Luo Lihua , Archambault Louis , Haghdoost Siamak , Fradette Julie , Sommar Pehr , Halle Martin 
Published: August 2023

Abstract

Long-term toxicities caused by cancer treatments have recently gained increasing recognition due to a steadily growing population of cancer survivors. Radiotherapy (RT) is a common treatment known to unintentionally harm surrounding normal tissuesincluding the skin, hindering wound healing even years after treatment. Our study aimed to elucidate the underlying mechanisms of these late-onset adverse effects caused by RT. By comparing paired skin biopsies from previously irradiated (RT+) and non-irradiated (RT−) sites in breast cancer survivors who underwent RT years ago, we discovered compromised wound healing capacity and impaired fibroblast functions in the RT+ skin. By employing ATAC-seq, we identified altered chromatin landscapes in RT+ fibroblasts, pinpointing THBS1 as a crucial epigenetically primed wound repair-related gene. Further confirmation of THBS1's significance during wound repair came from single-cell RNA-sequencing and spatial transcriptomic analysis of human wounds. Remarkably, heightened and sustained THBS1 expression was observed in RT+ fibroblasts in both mouse and human radiation wound models, leading to impaired fibroblast motility and contractility. Encouragingly, our study found that treatment with anti-THBS1 antibodies promoted ex vivo wound closure in RT+ skin from breast cancer survivors. These findings indicate that dermal fibroblasts retain a long-term radiation memory recorded in the form of epigenetic changes. Targeting this maladaptive epigenetic memory shows promise for mitigating the late-onset adverse effects caused by RT, offering potential solutions to improve the quality of life for cancer survivors.
Resilience through the Lens of Optimism, Self-Esteem, Life Satisfaction, and Virtues: Hierarchical Regression Analysis
Authors: Kim Jeong Han , Ntinda Kayi , Mora Elaine , Salinas Analynn , Rangel Gabriela , Lopez Jacqueline Mercado , Livingston Tori , Lee Dong Hun 
Published: August 2023

Abstract

Background The present study is to examine the effect virtues (courage, practical wisdom, integrity, committed action, emotional transcendence) in predicting resilience. Methods 595 adults participated in the study. At the first stage of regression analysis, resilience was predicted based on participants’ optimism, self-esteem, and life satisfaction scores. Then, five virtues that include courage, integrity, practical wisdom, committed action, and emotional transcendence were added in the second stage regression model, and changes in the Adjusted R2 were inspected via hierarchical regression analysis. Results In the first stage, 21% of the variance in resilience was explained by the combination of optimism, self-esteem, and life satisfaction. With the addition of virtue factors, the total variance of resilience explained was then improved to 56%. Conclusion Change in the Adjusted R2was 35%, indicative of virtue effect. Virtue was a popular concept in the early history of behavior science but became disfavored with the rise of empiricism as it was viewed as a moral and philosophical construct. The results of this study reassure that virtue can be studied empirically and findings necessitate additional research into the virtue effect in the context of resilience and adjustment to life's challenges.
CryoEM reveals the structure of an archaeal pilus involved in twitching motility.
Authors: Daum Bertram , Gaines Mathew , Sivabalasarma Shamphavi , Isupov Michail , Haque Risat , McLaren Mathew , Hanus Cyril , Gold Vicki , Albers Sonja-Verena 
Published: August 2023

Abstract

Amongst the major archaeal filament types, several have been shown to closely resemble bacterial homologues of the Type IV pili (T4P). Within Sulfolobales, member species encode for three types of T4P, namely the archaellum, the UV-inducible pilus (Uvp) and the archaeal adhesive pilus (Aap). Whereas the archaellum functions primarily in swimming motility, and the Uvp in UV-induced cell aggregation and DNA-exchange, the Aap plays an important role in adhesion and twitching motility. All previously solved Aap appear to have almost identical helical structures. Here, we present a cryoEM structure of the Aap of the archaeal model organism Sulfolobus acidocaldarius. We identify the component subunit as AapB and find that while its structure follows the canonical T4P blueprint, it adopts three distinct conformations within the pilus. The tri-conformer Aap structure that we describe challenges our current understanding of pilus structure and sheds new light on the principles of twitching motility.
Clinical evaluation of droplet digital PCR in the early identification of suspected sepsis patients in the emergency department: A prospective observational study
Authors: Jiang Sen , Zhao Dongyang , Wang Chunxue , Liu Xiandong , Yang Qian , Bao Xiaowei , Dong Tiancao , Li Gen , Gu Yi , Ye Yangqin , Sun Bingke , Xu Shumin , Zhou Xiaohui , Fan Lieying , Tang Lunxian 
Published: August 2023

Abstract

Background
Rapid and accurate diagnosis of the causative agents is essential for clinical management of bloodstream infections (BSIs) that might induce sepsis/septic shock. A considerable number of suspected sepsis patients initially enter the health-care system through an emergency department (ED), hence it is vital to establish an early strategy to recognize sepsis and initiate prompt care in ED. This study aimed to evaluate the diagnostic performance and clinical value of droplet digital PCR (ddPCR) assay in suspected sepsis patients in the ED.
Methods
This was a prospective single-centered observational study including patients admitted to the ED from 25 October 2022 to 3 June 2023 with suspected BSIs screened by Modified Shapiro Score (MSS) score. The comparison between ddPCR and blood culture (BC) was performed to evaluate the diagnostic performance of ddPCR for BSIs. Meanwhile, correlative analysis between ddPCR and the inflammatory and prognostic-related biomarkers were conducted to explore the relevance. Further, the health economic evaluation of the ddPCR was analyzed.
Results
258 samples from 228 patients, with BC and ddPCR performed simultaneously, were included in this study. The etiological diagnosis revealed that the ddPCR yielded 147 positive results, with a positive rate of 56.98%. In contrast, BC only detected 18 positives, 88.8% of which were identified by ddPCR. When considering BSIs with comprehensive microbiological testing, ddPCR shows an overall sensitivity of 91.73% and specificity of 81.6%, the optimal diagnostic power for quantifying BSI through ddPCR is achieved with a copy cutoff of 166. We further found that ddPCR exhibited a high accuracy especially in liver abscess patients. Among all the identified virus by ddPCR, EBV has a substantially higher positive rate with a link to immunosuppression. Moreover, the copies of pathogens in ddPCR were positively correlated with various markers of inflammation, coagulation, immunity as well as prognosis. With high sensitivity and specificity, ddPCR facilitates precision antimicrobial stewardship and reduces health care costs.
Conclusions
The multiplexed ddPCR delivers precise and quantitative load data on the causal pathogen, offers the ability to monitor the patient's condition and may serve as early warning of sepsis in time-urgent clinical situations as ED.
Factors Associated With Mental Health Outcomes Among Professional Athletes During the Social Isolation to COVID-19 Pandemic
Authors: Fernandes Isabelle A. , Costa Élida , Nicoliche Eduardo , Machado Caroline , Souza Erik , Ribeiro Pedro , Velasques Bruna 
Published: August 2023

Abstract
Purpose: The impact of the COVID-19 pandemic on athletes' mental health has been significant, leading to concerns about their careers due to suspended training and competitions. Thus, understanding the psychological mechanisms involved is crucial to promote mental health in athletes. This study aimed to evaluate the effects of the pandemic on the mental health of high-performance athletes.
Methods: A total of 676 participants completed an online form during the early stages of the pandemic, providing demographic data and responding to four inventories measuring psychological variables.
Results: results indicated that women, young adult athletes, and those facing financial loss exhibited higher levels of anxiety, depression, insomnia, and distress. Athletes receiving psychological assistance showed increased distress levels, while isolation did not significantly influence symptoms.
Conclusion: the COVID-19 pandemic negatively affected the mental health of professional athletes, particularly those experiencing financial difficulties, women, and young adults. However, further research is necessary to comprehend these findings' mechanisms.
Addressing the missing mass problem in galaxy clusters that is found with MOND-type theories
Authors: Penner A. Raymond 
Published: August 2023

Abstract
The MOND-type theories of AQUAdratic Lagrangian (AQUAL) and GRavitational Anti- Screening (GRAS) are applied to galaxy clusters. It will be shown that treating the baryonic mass distribution of the intracluster gas as being continuous leads to neglecting an important contribution to the clusters overall gravitational field. This is the localized mass density distribution that falls out from the theory which surrounds the protons within the gas. Including this contributor leads to an additional boost of approximately 60% to the gravitational field of clusters, over what MOND-type theories have previously been taken to provide. This accounts for most, if not all, of the shortfall of gravity or mass that has been attributed to clusters when MOND-type theories are used.
Research on User Demand Determination Method and Marketing Strategy for Home Broadband Business Based on Data Mining
Authors: Yang Xingchang 
Published: August 2023

Abstract

With the increasing demand for internet access, operators have launched home broadband business marketing activities targeting home users. However, due to the serious homogenization of products in the market and the unreasonable design of marketing plans, the related marketing work has certain difficulties. To address the above issues, this study first utilized MR fingerprint algorithm to construct a positioning model to confirm the location of household users. Then, by designing demand recognition indicators and using decision arithmetic to construct a demand model, the user’s needs and preferences were extracted to form a multi-dimensional user profile. Finally, precise marketing strategies were developed in the form of gifts based on the user’s location and personal needs. It is verified that the MR localization model has a recall rate of 95.2% and an accuracy rate of 96.2%. The on-demand model has a coverage rate of 83.8%, an accuracy rate of 96.3%, and a model accuracy of 89.7%. The proposed precision marketing strategy can achieve a success rate of 13.3% for cross network customers and 31.3% for marketing, and the failure rate of precision marketing strategy is lower than that of traditional marketing strategy among different reasons for marketing failure. Therefore, the MR positioning model proposed in the article has certain application value, and the developed precise marketing strategy has good marketing effects.
Phenolic resin derivatized TiO 2 -walnut shell carbon hybrid materials for solar photocatalytic phenol removal
Authors: Li Tao , Zhou Shiping , Li， Fengchuan , Li Huijuan 
Published: August 2023

Abstract
In this study, phenolic resin modified TiO2 (PF/TiO2), TiO2/WSC (Walnut shell carbon) and PF/TiO2/WSC hybrid composites were successfully synthesized by sol-gel method. The obtained TiO2-based composites were characterized by XRD, SEM, FTIR and XPS techniques. The phase characterization results showed that TiO2 phase is anatase in PF/TiO2/WSC (300℃, 2h) composite material, also TiO2 was uniformly loaded on the surface of the WSC to make the binding energy of Ti shift. Ti–O–C bonds are formed in the prepared TiO2/WSC and PF/TiO2/WSC (300℃, 2h) photocatalyst. When the catalyst dosage was 2.0 g/L, the initial phenol concentration was 80 mg/L, 10%PF/30%TiO2/WSC composite showed the best activity and its degradation rate was 88.14% under sunlight for 150 min. The active centers of PF/TiO2/WSC photocatalytic degradation of phenol were ·OH and ·O2- , and the photocatalytic degradation mechanism was proposed. The synergistic system of WSC adsorption and the superior photocatalytic performance of phenolic resin modified TiO2 achieved high degradation efficiency of pollutants in water and provided a new idea for solar photocatalytic removal of pollutants.
The solid solution in the system NaMgAl(SO4)3-KMgAl(SO4)3
Authors: Jensen Peter Grouleff , Balic-Zunic Tonci , Nielsen Ulla Gro , Kofoed Philip Miguel 
Published: August 2023

Abstract
We synthesized six samples in the compositional field NaMgAl(SO4)3-KMgAl(SO4)3 in 20 mol% increments from pure Na to pure K compounds. We investigated them by Powder X-Ray Diffraction, 23Na, and 27Al Nuclear Magnetic Resonance spectroscopy. The results confirm NaMgAl(SO4)3 as a unique phase identical to a new mineral found in fumaroles of Eldfell and Hekla volcanoes in Iceland. It tolerates less than 10 mol% K substitution for Na. There exists a compositional gap to around Na0.65K0.35MgAl(SO4)3 from where a solid solution extends to KMgAl(SO4)3. The mineral koryakite [NaKMg2Al2(SO4)6] is a member of the latter solid solution series. The crystal structures of all (Na,K)MgAl(SO4)3 phases are akin to NASICON (NA Super Ionic CONductor). NaMgAl(SO4)3 has R-3c symmetry and a disordered distribution of Mg and Al among the octahedral sites with only one unique site for the alkali atom. The members of the solid solution have R-3 symmetry with ordered Mg-Al distribution and two unique alkali sites with different preference for Na and K. In the crystal structure, the coordination of Na or K are trigonal antiprismatic and these share bases with two octahedral Mg/Al coordinations. These polyhedra are arranged in rows parallel to [001] interconnected by SO4 tetrahedral groups. The alkali atoms from a row lie on approximately the same (001) layers as the octahedrally coordinated atoms from the three neighboring rows. On the same level, parallel to (001), there are gaps in the other three neighboring rows where channels containing Na+ or K+ ions are formed.