bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tobramycin and antiglaucoma agents as increasing culprits of periorbital allergic contact dermatitis from topical ophthalmic medications: A 24‐year study from Turkey
Authors: Özkaya Esen , Keskinkaya Zeynep , Babuna Kobaner Goncagül 
Published: March 2023

AbstractBackgroundAllergic contact dermatitis (ACD) from topical ophthalmic medications (TOMs) poses an additional disease burden to patients who already suffer from eye problems.ObjectivesTo investigate the epidemiological/clinical profile of patients with periorbital ACD from TOMs in Turkey.Patients and MethodsThis was a retrospective, cross‐sectional, single tertiary centre study based on files of 75 patch tested patients with suspected periorbital ACD from TOMs among a total of 2801 consecutively patch tested patients with suspected ACD of any origin between 1996 and 2019.ResultsPeriorbital ACD was diagnosed in 25 of 75 (33.3%) patients (female:male = 1.8:1; age range: 6–85 years) with suspected ACD from TOMs showing an overall prevalence of 0.9% (25/2801) among the whole patch test population. Atopy was not present. Tobramycin‐containing TOMs were the most frequent culprits, followed by antiglaucoma preparations. Their frequency increased, whereas no new cases of neomycin‐induced ACD were observed after 2011. Positivities with thimerosal were of unknown clinical relevance, while benzalkonium chloride (BAC) caused ACD in two patients. The diagnosis would be missed in each 20% of patients without performing day (D) 4 and D7 readings and strip‐patch testing. Ten culprits were identified only by testing with patients' own TOMs in eight (32%) patients.ConclusionsAminoglycosides, particularly tobramycin, were the leading cause of ACD from TOMs. The frequency of ACD from tobramycin and antiglaucoma medications increased after 2011. BAC was a rare but important allergen. Additional D4 and D7 readings, strip‐patch testing, and testing with patients' own TOMs seem essential when patch testing with eye medications.
The representation of the economic situation in Lebanese satires: Unfiltered or propaganda in practice?
Authors: Asher Avner , Naor Dan , Mann Yossi 
Published: March 2023

AbstractIn recent years Lebanon has been facing economic challenges. Various Lebanese satire shows deal with the difficult economic situation in Lebanon, displaying the high cost of living, corruption, and poor infrastructure. It seems that these shows are faithfully airing public grievances, but is this the case? Are satire shows looking for the common Lebanese denominator while dealing with economic issues or highlighting the different and divisive issues? Does each TV station follow its sectarian affiliation regarding the economic situation? Or do they present socioeconomic issues neutrally? The article uses Edward S. Herman and Noam Chomsky's propaganda model to answer these questions. By examining six satire shows from five TV stations broadcast mainly between 2011 and 2016, the article will try to determine whether satire shows fit the propaganda model by shaping their messages or airing their sketches unfiltered.
Natural history of epilepsy in argininosuccinic aciduria provides new insights into pathophysiology: A retrospective international study
Authors: Elkhateeb Nour , Olivieri Giorgia , Siri Barbara , Boyd Stewart , Stepien Karolina M. , Sharma Reena , Morris Andrew A. M. , Hartley Thomas , Crowther Laura , Grunewald Stephanie , Cleary Maureen , Mundy Helen , Chakrapani Anupam , Lachmann Robin , Murphy Elaine , Santra Saikat , Uudelepp Mari‐Liis , Yeo Mildrid , Bernhardt Isaac , Sudakhar Sniya , Chan Alicia , Mills Philippa , Ridout Debora , Gissen Paul , Dionisi‐Vici Carlo , Baruteau Julien 
Published: March 2023

AbstractObjectiveArgininosuccinate lyase (ASL) is integral to the urea cycle, which enables nitrogen wasting and biosynthesis of arginine, a precursor of nitric oxide. Inherited ASL deficiency causes argininosuccinic aciduria, the second most common urea cycle defect and an inherited model of systemic nitric oxide deficiency. Patients present with developmental delay, epilepsy, and movement disorder. Here we aim to characterize epilepsy, a common and neurodebilitating comorbidity in argininosuccinic aciduria.MethodsWe conducted a retrospective study in seven tertiary metabolic centers in the UK, Italy, and Canada from 2020 to 2022, to assess the phenotype of epilepsy in argininosuccinic aciduria and correlate it with clinical, biochemical, radiological, and electroencephalographic data.ResultsThirty‐seven patients, 1–31 years of age, were included. Twenty‐two patients (60%) presented with epilepsy. The median age at epilepsy onset was 24 months. Generalized tonic‐clonic and focal seizures were most common in early‐onset patients, whereas atypical absences were predominant in late‐onset patients. Seventeen patients (77%) required antiseizure medications and six (27%) had pharmacoresistant epilepsy. Patients with epilepsy presented with a severe neurodebilitating disease with higher rates of speech delay (p = .04) and autism spectrum disorders (p = .01) and more frequent arginine supplementation (p = .01) compared to patients without epilepsy. Neonatal seizures were not associated with a higher risk of developing epilepsy. Biomarkers of ureagenesis did not differ between epileptic and non‐epileptic patients. Epilepsy onset in early infancy (p = .05) and electroencephalographic background asymmetry (p = .0007) were significant predictors of partially controlled or refractory epilepsy.SignificanceEpilepsy in argininosuccinic aciduria is frequent, polymorphic, and associated with more frequent neurodevelopmental comorbidities. We identified prognostic factors for pharmacoresistance in epilepsy. This study does not support defective ureagenesis as prominent in the pathophysiology of epilepsy but suggests a role of central dopamine deficiency. A role of arginine in epileptogenesis was not supported and warrants further studies to assess the potential arginine neurotoxicity in argininosuccinic aciduria.
Health literacy and consumer health information
Authors: Grant Maria J. 
Published: March 2023

AbstractThe rigours of the past few years have demonstrated the importance of good health literacy levels with the imperative of being able to obtain and interpret information to maintain and improve one's health never more apparent. With this in mind, this issue is focused on consumer health information, the gender and population group differences that exist in information seeking behaviour, the challenges of understanding medical explanations and terminology, and existing criteria to assess and ultimately produce better consumer health information.
Mood management through metaverse enhancing life satisfaction
Authors: Choi Dooyoung , Lee Ha Kyung , Kim Do Yuon 
Published: March 2023

AbstractThis study aims to explore a social metaverse's positive effects as mood management on consumers' life satisfaction and usage intentions. A total of 304 survey responses from active users of a popular social metaverse platform, Zepeto, were collected with help from an online survey firm. Structural equation modeling analysis was conducted using AMOS 25.0. The direct paths from social metaverse consumption as positive mood enhancement and negative mood alleviation to consumers' life satisfaction were significant, which led to greater usage intentions. Positive mood enhancement influenced usage intentions both directly and indirectly through increased life satisfaction; however, the effect of negative mood alleviation on usage intentions was fully mediated by life satisfaction. Interestingly, for the players who spend money in the social metaverse, only the path from negative mood alleviation to usage intentions mediated by life satisfaction was significant.
l‐Arginine and l‐lysine can weaken the intermolecular interactions of main myofibrillar proteins: the roles in improving the tenderness of pork Longissimus lumborum muscle
Authors: Chen Li , Li Rui , Zhou Cunliu 
Published: March 2023

SummaryThis work aims at investigating the mechanisms underlying the effects of l‐arginine and l‐lysine on the tenderness of pork Longissimus lumborum muscle. The results indicated that on day 7, L‐arginine and l‐lysine were able to decrease the shear force from 71.47 to 27.59 or 32.53 N, but raise the myofibrillar fragmentation index from 70.93 to 88.2 or 92.4, compared to the control. Additionally, l‐arginine inhibited the degradation of desmin, troponin‐T and titin; while l‐lysine inhibited the degradation of desmin, troponin‐T, titin and nebulin. l‐Arginine, especially l‐lysine alleviated the Z‐disc damage, while accelerated the M‐line damage. l‐Arginine and l‐lysine promoted the extraction of myosin, titin and some unidentified proteins, decreased ionic bonds but increased hydrophobic interactions. The results suggest that the weakening of the intermolecular interactions between main myofibrillar proteins by l‐arginine or l‐lysine may play crucial roles in improving meat tenderness. The finding may broaden the way to tenderise meat.
Profile of people attending emergency departments with thoughts of self‐harm and suicide: A descriptive study of a nurse‐led programme in Ireland
Authors: Kavalidou Katerina , Zortea Tiago C. , Griffin Eve , Troya M. Isabela 
Published: March 2023

AbstractIncreasing research has been conducted on individuals presenting with self‐harm at emergency departments (EDs). However, less is known about individuals presenting to EDs with only self‐harm ideation. We aimed to describe the characteristics of those attending Irish hospitals with self‐harm ideation and investigate any differences in comparison to those presenting with suicide ideation. A prospective cohort study was conducted on Irish ED presentations due to suicidal and self‐harm ideation. Data were obtained from the service improvement data set of a dedicated nurse‐led National Clinical programme for the assessment of those presenting to Irish emergency departments due to Self‐harm and Suicide‐related Ideation (NCPSHI). A total of 10 602 anonymized presentation data were analysed from 1 January 2018 to 31 December 2019. Descriptive analysis was conducted to compare those with suicidal and self‐harm ideation on sociodemographic and care interventions. Being female and aged <29 were more prevalent among the self‐harm ideation presentations. Compared to the self‐harm ideation group, a higher proportion of those with suicidal thoughts received an emergency care plan (63% vs 58%, p = 0.002) and General Practitioner letter sent within 24 h of presentation (75% vs 69%, p = 0.045). Little variation was found between hospitals for self‐harm ideation in both years. Our study suggests that females and younger populations are more prevalent in hospital presentations due self‐harm ideation, while presentations related to suicidal ideation are more often made by males and involving substance use. Attention should be given to the relationship between clinicians' attitudes towards care provision and the content of suicide‐related ideation ED disclosure.
RETRACTED: Effect of honey dressing in the management of diabetic foot ulcers: A meta‐analysis
Authors: Li Shaoting , Xiao Ting , Ye Ning , Yang Guosheng , Chen Haiting , Liang Xia , Li Tuodi , Wang Jinying , Peng Yaozhong , Li Yuan , Liu Yanping 
Published: March 2023

AbstractA meta‐analysis study to assess the effect of honey dressing (HD) in the management of diabetic foot ulcer (DFU). A comprehensive literature examination till January 2023 was implemented and 1794 linked studies were appraised. The picked studies contained 882 subjects with DFUs were in the picked studies' baseline, 424 of them were using HD, and 458 were using a control. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to calculate the consequence of HD in the management of DFUs after DFU by the dichotomous and continuous styles and a fixed or random model. The HD applied to DFUs caused a significantly higher wound healing rate (OR, 2.06; 95% CI, 1.45‐2.93, P < .001) and lower wound healing time (MD, −10.42; 95% CI, −16.27‐ −4.58, P < .001) compared with the control. The HD applied to DFUs caused a significantly higher wound healing rate and lower wound healing time compared with the control. Although precautions should be taken when commerce with the consequences since most of the picked studies for this meta‐analysis was with low sample sizes.
The effects of a sleep‐focused smartphone application on insomnia and depressive symptoms: a randomised controlled trial and mediation analysis
Authors: Werner‐Seidler Aliza , Li Sophie H. , Spanos Samantha , Johnston Lara , O'Dea Bridianne , Torok Michelle , Ritterband Lee , Newby Jill M. , Mackinnon Andrew J. , Christensen Helen 
Published: March 2023

BackgroundRates of depression are increasing among adolescents. A novel way to reduce depression is by improving sleep. We evaluated whether an app‐based intervention for insomnia improved sleep and depression, and whether changes in insomnia mediated changes in depression.MethodsWe conducted a 2‐arm single‐blind randomised controlled trial at the Black Dog Institute in Australia. Adolescents 12–16 years experiencing insomnia symptoms were randomly allocated to receive Sleep Ninja, an app‐delivered cognitive behavioural therapy program for insomnia, or to an active control group involving weekly text message sleep tips. Assessments took place at baseline, 6 weeks (post‐intervention) and 14 weeks (post‐baseline). Co‐primary outcomes were symptoms of insomnia and depression at post‐intervention (primary endpoint). Intent‐to‐treat analyses were conducted. The trial is registered with the Australian and New Zealand Clinical Trials Registry, number ACTRN12619001462178.ResultsBetween October 25, 2019, and September 6, 2020, 264 participants were randomised to receive Sleep Ninja (n = 131) or to the control group (n = 133). Relative to the control group, those allocated to the intervention reported a greater reduction in insomnia symptoms at 6 weeks (95% CI: −2.96 to −0.41, d = .41) and 14 weeks (95% CI: −3.34 to −0.19, d = .39), and a greater reduction in depression symptoms at 6 weeks (95% CI: −3.46 to −0.56, d = .28) but not 14 weeks (p < 1). Change in insomnia mediated change in depression. No adverse events were reported.ConclusionsAn app‐delivered program for insomnia could be a practical, non‐stigmatising and scalable way to reduce symptoms of insomnia and depression among adolescents experiencing difficulties getting enough good quality sleep.
Dividends and share repurchases during the COVID‐19 economic crisis
Authors: Mazur Mieszko , Dang Man , Vo Thi Thuy Anh 
Published: March 2023

AbstractIn this article, we examine dividends and share repurchases of S&P 1500 firms during the COVID‐19 crisis characterized by the stock market crash and a relatively quick stock price recovery propelled by technology stocks. We find that the great majority of firms either maintain or increase the level of dividends during the crisis period. Yet, the relation between the dividend payout and reported earnings is negative and significant. This relation also holds for other types of payouts, including share repurchases and special dividends. Moreover, we find that both forecasted and realized earnings of up to 1 year into the future are negatively associated with current dividends, implying that existing payout policies are unsustainable in the longer term. Surprisingly, the difference‐in‐differences test shows that firms strongly affected by the COVID‐19 crisis have higher dividend payouts (relative to net earnings) compared to unaffected firms. The same test indicates that strongly affected firms significantly reduce repurchases.
Advancing operational flood forecasting, early warning and risk management with new emerging science: Gaps, opportunities and barriers in Kenya
Authors: Kiptum Augustine , Mwangi Emmah , Otieno George , Njogu Andrew , Kilavi Mary , Mwai Zacharia , MacLeod Dave , Neal Jeff , Hawker Laurence , O'Shea Tom , Saado Halima , Visman Emma , Majani Bernard , Todd Martin C. 
Published: March 2023

AbstractKenya and the wider East African region suffer from significant flood risk, as illustrated by major losses of lives, livelihoods and assets in the most recent years. This is likely to increase in future as exposure rises and rainfall intensifies under climate change. Accordingly, flood risk management is a priority action area in Kenya's national climate change adaptation planning. Here, we outline the opportunities and challenges to improve end‐to‐end flood early warning systems, considering the scientific, technical and institutional/governance dimensions. We demonstrate improvements in rainfall forecasts, river flow, inundation and baseline flood risk information. Notably, East Africa is a ‘sweetspot’ for rainfall predictability at sub‐seasonal to seasonal timescales for extending forecast lead times beyond a few days and for ensemble flood forecasting. Further, we demonstrate coupled ensemble flow forecasting, new flood inundation simulation, vulnerability and exposure data to support Impact based Forecasting (IbF). We illustrate these advances in the case of fluvial and urban flooding and reflect on the potential for improved flood preparedness action. However, we note that, unlike for drought, there remains no national flood risk management framework in Kenya and there is need to enhance institutional capacities and arrangements to take full advantage of these scientific advances.
Modelling economic risk to sea‐level rise and storms at the coastal margin
Authors: Eaves Ashton , Kench Paul , McDonald Garry , Dickson Mark , Storey Belinda 
Published: March 2023

AbstractWe develop a methodological approach through integrated assessment using System Dynamics modelling and Scenario Planning to investigate the economic vulnerability of coastal communities to the compounding impacts of sea‐level rise (SLR) and storm flooding and inundation associated with climate change. The approach uses a coastal flood risk assessment that quantifies physical drivers alongside socio‐economic well‐being for coastal communities to provide a methodology for managing uncertain futures through causal relationships in System Dynamics. A New Zealand case study is used to illustrate the long‐term economic impacts of inaction under different SLR projections and recognise critical tolerance thresholds to help exposed property owners plan their future. Modelling scenarios using this integrated approach identified two stand‐out drivers that influence a behavioural response of communities to coastal inundation at the local scale: first, the ongoing likelihood of risk transfer to the insurance industry, and second, the decisions of households and firms to accept risk for the added value of coastal living. Model outputs suggest that the threat posed by coastal hazards drives a behavioural, socio‐economic response that exceeds the initial economic exposure of capital assets. In the economic short term (1–10 years) and medium term (10–20 years), vulnerable communities accept the risk of capital loss and loss of insurability, favouring the amenity of coastal living. However, in the long term (+20 years), economic losses from repeat flooding increase risk‐based insurance premiums, promote insurance withdrawal and drive negative corrections in property valuations. Unanticipated insights were obtained from the modelling, including the likely timing of tolerance thresholds, particularly the insurance withdrawal point, which is critical to insurer/consumer decision‐making and community planning.
Transcranial Doppler ultrasonography in tuberculous meningitis: A systematic review
Authors: Badillo Stephanie Patricia J. , Navarro Jose C. , Qureshi Adnan I. , Sharma Vijay K. 
Published: March 2023

AbstractBackground and PurposeTuberculous (TB) meningitis is a common type of central nervous system infection, and may cause multifocal cerebral infarctions due to the involvement of cerebral vasculature. This systematic review aims to review and synthesize the utility of transcranial Doppler (TCD) in TB meningitis.MethodsThis is a systematic review of observational studies on the use of TCD in patients diagnosed to have TB meningitis. Study outcomes included changes in TCD parameters during stages of TB meningitis, frequency of neurologic complications (such as hydrocephalus, vasculopathy, and cerebral infarction), correlation of TCD findings with neuroimaging, and functional outcomes.ResultsFive studies were included with a total of 141 participants, with ages from 4 months to 75 years. The most common neurologic complication was hydrocephalus (87.1%), cerebral infarction (29.2%), and arterial stenosis (26.3%). There was increased mean flow velocity (MFV) most commonly in the middle cerebral artery in the early stage of TB meningitis, and decreased MFV in the advanced disease stage. TCD findings of stenosis were well correlated with CT or MR angiogram. Among patients with hydrocephalus, pulsatility indices were significantly decreased after ventriculoperitoneal shunting.ConclusionsA considerable proportion of patients with TB meningitis develop cerebral hemodynamic disturbances which lead to cerebral ischemia and affect clinical outcomes. TCD is a reliable tool for the diagnosis of vasculopathy and increased intracranial pressure and can thus help monitor disease progression and treatment response. Future studies with larger populations and longer follow‐ups are recommended to determine the association of TCD findings with functional outcomes.
Effective algorithms for optimal portfolio deleveraging problem with cross impact
Authors: Luo Hezhi , Chen Yuanyuan , Zhang Xianye , Li Duan , Wu Huixian 
Published: March 2023

AbstractWe investigate the optimal portfolio deleveraging (OPD) problem with permanent and temporary price impacts, where the objective is to maximize equity while meeting a prescribed debt/equity requirement. We take the real situation with cross impact among different assets into consideration. The resulting problem is, however, a nonconvex quadratic program with a quadratic constraint and a box constraint, which is known to be NP‐hard. In this paper, we first develop a successive convex optimization (SCO) approach for solving the OPD problem and show that the SCO algorithm converges to a KKT point of its transformed problem. Second, we propose an effective global algorithm for the OPD problem, which integrates the SCO method, simple convex relaxation, and a branch‐and‐bound framework, to identify a global optimal solution to the OPD problem within a prespecified ε‐tolerance. We establish the global convergence of our algorithm and estimate its complexity. We also conduct numerical experiments to demonstrate the effectiveness of our proposed algorithms with both real data and randomly generated medium‐ and large‐scale OPD instances.
On the Shoulders of Giants Or the Back of a Mule: Awareness of Multiplicity In Citational Politics
Authors: Blell Mwenza 
Published: March 2023

AbstractCitational practices reflect values and valuation in academia. Far from being merely consciously or unconsciously political, they reflect academic “upbringing” in complex ways, and, although one may be unhappy at how they were raised, it still may not be clear how to live better. In this article, I highlight aspects of my upbringing in anthropology, noting how I was instructed in citational practice by senior anthropologists from biological and social anthropology. In exploring my journey from naivete to an understanding of citational politics, I describe two figures, the giant and the mule. These figures illustrate the impacts of the practices I was taught. One comes to us from the history of great white men of Europe, the other from Black feminist anthropological fiction of the United States.