bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valuation of cryptoassets in EU insolvency: Challenges and prospects
Authors: Kostoula Theodora 
Published: April 2023

AbstractHow and when to determine the value of cryptoassets in insolvency proceedings? This question becomes more topical with the increasing adoption of volatile cryptoassets such as Bitcoin. As many of these assets do not have an ‘apparent’ value that may be readily ascertainable, it is not always clear how their value may be established. This presents significant challenges to their proper valuation in the context of insolvency proceedings and requires certain attention to efficiently confront the implications on the assessment of claims, the calculation of their value and the determination of the recoverable amount. Accordingly, this Article exposes the arising challenges and implications from an EU insolvency perspective, with the aim to trigger considerations for legislative interventions at EU level.
Revisiting the impact of ASC 280: Liquidity, operating performance, and market value
Authors: Chuwonganant Chairat , Olibe Kingsley O. , Strawser Jeffrey W. , Strawser William R. 
Published: April 2023

AbstractThe Financial Accounting Standards Board (FASB) enacted Statement of Financial Accounting Standards No. 131 (now Accounting Standards Codification 280) to improve the valuation of firms’ future growth opportunities through changes to segment disclosures. Prior research on foreign investment relies primarily on levels analyses. Using both changes and levels analyses, we provide evidence that investments in foreign fixed assets by US firms is significantly and positively related to operating income and net cash flows from operations. Foreign fixed assets are also significantly and positively related to stock prices, returns, and stock liquidity. Generally, our results suggest that increases in international diversification are related to increased operating performance and liquidity, while our price and returns results suggest that investors incorporate geographic asset data in their valuation models.
sCXCL16 as a prognostic biomarker for COVID‐19 outcome
Authors: Boukhalfa Yasmine , Stambouli Nejla , Driss Adel , Daiki Maissa , Abouda Amal , Razgallah Rabie , Gharsallah Hedi , Sellami Walid , Abid Rym , Hannachi Souha , Battikh Riadh , Benmoussa Mohamed , Mazigh Chakib , Ferjani Mustapha , Elgaaied Amel B. , Labbene Iheb 
Published: April 2023

AbstractAs elevated levels of the soluble CXCL16 (sCXCL16) chemokine have been reported in severe coronavirus disease 2019 (COVID‐19) patients, this study examined whether sCXCL16 concentration on the first day of hospitalization predicted death in COVID‐19 patients. A total of 76 patients with COVID‐19 were admitted to the Military Hospital of Tunis, Tunisia, between October 2020 and April 2021, and later classified as survivors or nonsurvivors based on their outcomes. At admission, the groups were matched by age, gender, comorbidities, and the percentage of patients with moderate conditions. On the first day of admission, serum's sCXCL16 concentrations were measured using a magnetic‐bead assay. There was an eightfold increase in serum sCXCL16 levels in the nonsurvivors’ group (3661.51 ± 2464.87 pg/mL vs. 454.3 ± 338.07 pg/mL, p < 0.0001). For the optimal cutoff value of sCXCL16 at 2095 pg/mL, we found a 94.6% sensitivity and a 97.4% specificity, with an area under curve of 0.981 (p = 5.03E−08; 95% confidence interval [95% CI]: 0.951–1.0114). Considering the risk of death at a concentration above the threshold, the unadjusted odds ratio was 36 (p < 0.0001). The adjusted odd ratio was estimated at 1.003 (p < 0.0001; 95% CI: 1.002–1.004). Finally, there was a significant difference between survival and nonsurvival groups in leukocyte numbers (p = 0.006), lymphocytes (p = 0.001), polymorphonuclear neutrophils (p = 0.001), and C‐reactive protein levels (p = 0.007), except for monocytes (p = 0.881). Based on these results, sCXCL16 level could be used for detecting nonsurvival COVID‐19 patients. Therefore, we recommend assessing this marker in hospitalized COVID‐19 patients.
Learning from an equitable, data‐informed response to COVID‐19: Translating knowledge into future action and preparation
Authors: Stanzler Morgen , Figueroa Johanna , Beck Andrew F. , McPherson Marianne E. , Miff Steve , Penix Heidi , Little Jessica , Sampath Bhargavi , Barker Pierre , Hartley David M. 
Published: April 2023

AbstractIntroductionThe COVID‐19 pandemic revealed numerous barriers to effectively managing public health crises, including difficulties in using publicly available, community‐level data to create learning systems in support of local public health decision responses. Early in the COVID‐19 pandemic, a group of health care partners began meeting to learn from their collective experiences. We identified key tools and processes for using data and learning system structures to drive equitable public health decision making throughout different phases of the pandemic.MethodsIn fall of 2021, the team developed an initial theory of change directed at achieving herd immunity for COVID‐19. The theoretical drivers were explored qualitatively through a series of nine 45‐min telephonic interviews conducted with 16 public health and community leaders across the United States. Interview responses were analyzed into key themes to inform potential future practices, tools, and systems. In addition to the interviews, partners in Dallas and Cincinnati reflected on their own COVID‐19 experiences.ResultsInterview responses fell broadly into four themes that contribute to effective, community driven responses to COVID‐19: real‐time, accessible data that are mindful of the tension between community transparency and individual privacy; a continued fostering of public trust; adaptable infrastructures and systems; and creating cohesive community coalitions with shared alignment and goals. These themes and partner experiences helped us revise our preliminary theory of change around the importance of community collaboration and trust building and also helped refine the development of the Community Protection Dashboard tool.ConclusionsThere was broad agreement amongst public health and community leaders about the key elements of the data and learning systems required to manage public health responses to COVID‐19. These findings may be informative for guiding the use of data and learning in the management of future public health crises or population health initiatives.
Construction of an Antithrombotic and Anti‐Inflammatory Polyethersulfone Membrane
Authors: Fu Xiao , Lei Ting , Tang Ci , Peng Jie 
Published: April 2023

AbstractIn addition to being the core factor in thrombosis, thrombin is involved in various inflammatory disease responses, but few studies have examined whether and how it is involved in membrane‐related inflammation. In this study, the thrombin inhibitor dabigatran is used to modify a polyethersulfone dialysis membrane. The modified membrane shows good hydrophilic properties and dialysis performance. It reduces the thrombin level in a targeted manner, thereby significantly inhibiting coagulation factor activation (based on the prothrombin time, international normalized ratio, activated partial thromboplastin time and thrombin time) and reducing the fibrinogen level and platelet adhesion. On thromboelastography, it shows excellent dynamic antithrombotic capacity. The modified membrane inhibited membrane‐related inflammation by inhibiting the production of the inflammatory mediators C‐reactive protein (CRP), interleukin‐6 (IL‐6), and interleukin‐1β (IL‐1β) via the thrombin/complement C5a pathway. Moreover, it is found to be safe in an in vivo study. Thus, the dabigatran‐modified polyethersulfone membrane may reduce dialysis‐related complications through its dual antithrombotic and anti‐inflammatory effects.
Enhanced nuclear translation is associated with proliferation and progression across multiple cancers
Authors: Zou Sailan , Kim Byung‐Wook , Tian Yan , Liu Geng , Zhang Jiawei , Zerda Ricardo , Li Zhuo , Zhang Guixiang , Du Xiao , Lin Weiqiang , Gao Xiang , Huang Wendong , Fu Xianghui 
Published: April 2023

AbstractRecent technological advances have re‐invigorated the interest in nuclear translation (NT), but the underlying mechanisms and functional implications of NT remain unknown. Here we show that NT is enhanced in malignant cancer cells and is associated with rapid cell growth. Nuclear ribopuromycylation analyses in a panel of diverse cell lines revealed that NT is scarce in normal immortalized cells, but is ubiquitous and robust in malignant cancer cells. Moreover, NT occurs in the nucleolus and requires normal nucleolar function. Intriguingly, NT is reduced by cellular stresses and anti‐tumor agents and positively correlates with cancer cell proliferation and growth. By using a modified puromycin‐associated nascent chain proteomics, we further identified numerous oncoproteins that are preferentially translated in the nucleus, such as transforming growth factor‐beta 2 (TGFB2) and nucleophosmin 1 (NMP1). Specific overexpression of TGFB2 and NMP1 messenger RNAs in the nucleus can increase their protein levels and promote tumorigenesis. These findings establish a previously unknown link between NT and malignancy and suggest that cancer cells might have adapted a mechanism of NT to support their need for rapid growth, which highlight the potential of NT in tumorigenesis and might also open up new possibilities for therapeutic targeting of cancer‐specific cellular functions.
Upper tropospheric cloud‐radiation interaction induced by monsoon surge over the South China Sea
Authors: Koseki Shunya , Fonseca Ricardo , Koh Tieh‐Yong , Teo Chee‐Kiat 
Published: April 2023

AbstractWe have investigated cloud formation over the South China Sea in the upper troposphere and its impacts on the radiation budget of the troposphere and ocean surface under monsoon surges using satellite and reanalysis products and an atmospheric numerical model. During strong surges (SS), the upper tropospheric (UT) cloud formation in central South China Sea shows a clear diurnal cycle, peaking around 12–14 local solar time when the incoming solar radiation is the strongest. The enhanced UT clouds attenuate the incoming solar radiation in the upper troposphere reducing the net downward shortwave radiation flux at the surface by approximately 28% in SS compared with no surge case. In contrast the downward longwave radiation flux is enhanced mainly from the middle to upper troposphere in SS. The cooling because of the diminished incoming shortwave radiation overwhelms the warming due to the longwave radiation at the ocean surface. This cloud radiative forcing is observed partly over the cold tongue in sea surface temperature (SST) in the South China Sea. Numerical simulations with a 1‐dimensional slab ocean model suggests that the monsoon‐induced UT cloud radiative forcing contributes partially to maintain and reinforce the SST cold tongue with a tendency of about 0.08 K in 6 days or about 1/6 of one standard deviation of the Cold Tongue Index in December. The latent heat flux due to the monsoon surge is still the most significant factor maintaining the cold tongue.
Treatment‐resistant depression begs for innovation
Authors: Benabou Reina 
Published: April 2023

Major depressive disorder (MDD) is a leading cause of disability in the United States, and an estimated one‐third of the 21 million American adults living with MDD have treatment‐resistant depression (TRD), diagnosed when patients do not respond to two different antidepressants of adequate dose and duration. This creates significant, ongoing burden — emotional, functional and economic — on the individual, their loved ones and society that cannot be overstated.
Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High‐Fat Diet through Regulating the Glycolytic Pathway
Authors: Luo Min , Zhuge Xiuhong , Ji Lin , Wang Jinyuan , Mo Yi , Tan Yongpeng , Zhou Leguang , Lei Xiaocan , Huang Hua 
Published: April 2023

ScopeObesity is a global threat for male infertility, which can cause spermatogenic dysfunction. However, there are no available drugs for the treatment of obesity‐induced spermatogenesis dysfunction. This study characterizes the protective effects of icariin (ICA) on spermatogenesis dysfunction in obese mice.Methods and resultsObese mice are induced by a high‐fat diet to determine whether ICA has a protective effect. ICA treatment reduces body weight and the proportion of abnormal sperm, brings about a recovery of sperm count, and the number of spermatogenic cells. ICA treatment improves histopathological changes of the testes and inhibits testicular apoptosis, as evidenced by reduced the expression of Bax and increased the expression of Bcl‐2, PCNA, WT1, GATA‐4, vimentin, HK2, PKM2, and LDHA in the testes. In vitro, TM4 cells are treated with 0.4 mm palmitic acid (PA) to induce Sertoli cell injury, and are then utilized for ICA treatment. ICA improves PA‐induced decreased TM4 cells viability, reduces the levels of lactate, and increases the levels of pyruvate and the expression of HK2, PKM2, and LDHA and restores the glycolytic process in vitro.ConclusionICA ameliorates spermatogenic dysfunction in obese mice by regulating glycolytic activity, providing effective strategies for obesity treatment.
Variations of the in‐situ stress within nonhomogeneous layers of the subsurface rock induced by changes in pore fluid pressure
Authors: Su Xing , Mehrabian Amin 
Published: April 2023

AbstractThis paper presents a three‐dimensional analytical solution for deformation and stress change inside and outside a porous layer of rock subjected to prescribed axisymmetric disturbance in the pore fluid pressure. The porous layer is confined between two impermeable layers of rock. Different mechanical moduli are considered for the porous and confining strata. The solution is derived from Navier's equations of static equilibrium while considering the continuity of stress and deformation across the rock layers which are assumed to follow linearly poroelastic constitutive behavior. Results for the case of uniform pore fluid pressure change within the porous layer are demonstrated in terms of rock deformation, as well as changes in the magnitude and orientation of principal stresses, inside and outside the porous layer. Variations of these results with key problem parameters including the stiffness ratio of rock layers and the aspect ratio of disturbed pore pressure volume are presented. Findings indicate the large effect of layers heterogeneity on redistribution and reorientation of the in‐situ stress, yet, less significantly on deformation of the porous layer. Results further reveal the substantial error rates that uniaxial strain models may produce in estimating the stress path of depleted or injected reservoirs.
Nephron sparing surgery and surgical management of intravascular extension of Wilms tumor
Authors: Tracy Elisabeth T. , Vasconcelos‐Castro Sofia , Malogolowkin Marcio , Loh Amos Hong Pheng , Kotagal Meera , Glick Richard D. , Warmann Steven , Apezzato Maria Lucia de Pinho , Cost Nicholas G. , Godzinski Jan 
Published: April 2023

AbstractAlthough general treatment approaches for Wilms tumor differ between Children's Oncology Group and Société Internationale d'Oncologie Pédiatrique‐Renal Tumors Study Group protocols, complex tumors that may be candidates for nephron sparing surgery (NSS) and those with intravascular tumor extension represent a management challenge. In both of these scenarios, anatomic considerations are important in guiding management, making these areas of significant similarities in management between the international groups. This paper aims to explore the current approaches to NSS and intravascular tumor extension by both international groups, with attention to the evidence supporting these approaches and current knowledge gaps.
Facile fabrication of flexible TPU‐based microcellular nanocomposite piezoresistive sensors with tunable piezoresistivity via modulating cell structure
Authors: Li Xiao‐Dan , Huang Han‐Xiong 
Published: April 2023

AbstractThermoplastic polyurethane/multi‐wall carbon nanotubes/graphene nanoplates (TPU/MWCNTs/GNPs) microcellular nanocomposites used for assembling flexible piezoresistive sensors are prepared via melt mixing and then supercritical carbon dioxide foaming. The adjustable piezoresistivity and higher resilience of the sensors are achieved by creating tunable closed‐cell structure in the nanocomposites through foaming. The sensor assembled with the microcellular nanocomposite having a relatively uniform cell structure and moderately thicker cell walls exhibits a wider linear response range (0%–45% strain) and relatively higher sensitivity (gauge factor of 1.84). It shows repeatable piezoresistive response and good durability, and can be used to detect typical medium‐high pressure human motions. The sensor assembled with the microcellular nanocomposite having moderately larger cell diameter and thinner cell walls displays a higher sensitivity (gauge factor of 4.17) and obviously lower detection limit (0.8 kPa), but a narrower linear response range (0%–13% strain). It can accurately detect weak human physiological signals. Moreover, the enhanced performances of the sensors are also attributed to the hybrid conductive nanofillers (1D MWCNTs and 2D GNPs) distributing in the cell walls. The strategy for preparing the microcellular nanocomposites in this work gives a guidance for the development of flexible sensors in wide‐range of pressure sensing applications.
Encountering young caregivers: Attitudes and practices of healthcare professionals caring for cancer patients
Authors: Justin Pauline , Dorard Géraldine , Untas Aurélie 
Published: April 2023

AbstractIntroductionCancer and its treatments severely limit patients' daily lives. Relatives of patients may provide caregiving assistance to help patients cope with these limitations. Many children and adolescents—referred to as young caregivers (YCs)—provide support for patients. However, healthcare professionals do not always recognize YCs, and when they do, healthcare professionals are unsure how to support them.ObjectiveThis study aimed to explore healthcare professionals' attitudes toward and practices when encountering YCs and to compare these aspects according to their experiences with YCs.MethodsIn total, 395 oncology healthcare professionals (mean age 43.3 years; 84.8% females) participated in the study and completed an online survey.ResultsOnly 1 in 2 professionals reported ever meeting a YC. The majority identified YCs by YCs' frequent presence in the department. No significant difference in attitudes was observed between professionals who had met a YC and those who had never met one. The support provided by professionals to YCs generally consisted of vigilance and exchanges. However, many professionals expressed a need to know where they can refer YCs for assistance.ConclusionsThese findings underline the importance of improving the practices of healthcare professionals to help them better identify and support the YCs they meet.
Physiotherapy strategies for functional improvement in a child with complicated hereditary spastic paraplegia: 1‐year follow‐up of a case report using a changing criterion design
Authors: Choi Ji‐Young , Oh Duck‐Won , Son Sung‐Min , Kim Chang‐Ju 
Published: April 2023

AbstractBackgroundand Purpose: Hereditary spastic paraplegias (HSP) are a group of clinically diverse genetic disorders that share the neurologic symptom of difficulty in walking due to progressive serious muscle weakness and spasticity in the legs. This study describes a physiotherapy program for improving the functional ability of a child diagnosed with complicated HSP and reports the treatment results.MethodsA 10‐year‐old boy with complicated HSP received a physiotherapy intervention that included strengthening of the leg muscles and treadmill training for 1 h per session, three to four times a week for 6 weeks. Outcome measures included sit‐to‐stand, 10‐m walk, 1‐min walk tests, and gross motor function measures (dimensions D and E).ResultsAfter the intervention, the sit‐to‐stand, 1‐min walk, and 10‐m walk test scores improved by 6.75 times, 2.57 m, and 0.05 m/s, respectively. Furthermore, the gross motor function measure dimensions D and E scores improved by 8% (46%–54%) and 5% (22%–27%), respectively. The gains in each parameter were maintained at the 3‐ and 6‐month and 1‐year follow‐ups.ConclusionThese results suggest that structured physiotherapy programs can benefit the functional rehabilitation of children with complicated HSP.
Gravitational Decoupling as a Generator of Curvature and Matter Distribution
Authors: Tello‐Ortiz Francisco , Bargueño Pedro , Alvarez A. , Contreras Ernesto 
Published: April 2023

AbstractIn this work, we generate curved Lorentzian manifolds from a flat Minkowskian space–time, through the Gravitational Decoupling by the Minimal Geometric Deformation method interpreting the decoupling sector as a generator of curvature and matter distribution. In particular, we obtain some new wormhole geometries by imposing either physically relevant equations of state or certain physically–motivated geometric constraints. These solutions are analyzed in detail. For all these solutions, we study the associated energy conditions, the geometric behavior and construct their embedding diagrams.
Local Activity in a Self‐Assembled Quantum Dot System
Authors: Wan Qin , Zeng Fei , Yu Junwei , Chen Tongjin , Lu Ziao , Pan Feng 
Published: April 2023

AbstractResearch and development of memristor‐based neuromorphic networks has entered the stage of large‐scale application. However, the understanding of the adopted memristors is still vague, meaning a thorough study of their local activity is urgently necessary. Here, an electrode tip is created to focus the electrical field on the active locality, where the NbO quantum dot (QD) self‐assembles in the middle of the Nb‐doped AlNO film. The QD size can fluctuate under an appropriately controlled electron beam or electrical field, suggesting reversible nucleation behavior. The QD system periodically pulses when the input is enhanced to a co‐tunneling threshold or to one that activates the oscillation of the QD size. These two mechanisms are attributed to the local activity accounting for the information‐energy conversion of the QD system. This study presents a more precise and low energy‐consumption approach for neuromorphic computing by manipulating the local activity.
Rapid target screening and quantitative analysis of various environmental pollutants
Authors: Bořík Adam , Nováková Petra , Stroski Kevin M. 
Published: April 2023

RationaleThe presented analytical method demonstrates a straightforward approach for environmental applications based on laser diode thermal desorption (LDTD). The study aims to examine abilities to achieve environmentally relevant outcomes for different types of pollutants with a fast method following the green chemistry principle.MethodsTreatment of environmentally relevant sample matrix (river water) was limited to filtration with a cellulose filter. Samples fortified with analytes were spotted in a LazWell plate and dried before analysis. Samples thermally desorbed using LDTD were detected with Q Exactive hybrid high‐resolution mass spectrometer operation in full‐scan data‐dependent acquisition mode (LDTD‐FullMS‐dd‐MS/MS).ResultsLDTD‐FullMS‐dd‐MS/MS exhibits the lowest quantification limits for anatoxin‐A, atrazine, caffeine, methamphetamine, methylbenzotriazole, paracetamol, perfluorobutanoic acid, perfluorohexanoic acid, and perfluorooctanoic acid of between 0.10 and 1.0 ng mL−1 in the environmentally relevant sample matrix.ConclusionsThe developed method was successfully evaluated for different environmental pollutants and radically reduced sample treatment and time requirements for analysis and sample preparation.