bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed response of net primary productivity with climate change in the Yiluo River basin
Authors: Tian Zihao , Qin Tianling , Wang Huiliang , Li Yizhe , Yan Sheng , Hou Jun , Li Chenhao , Abebe Sintayehu A. 
Published: January 2023

Climatic factors are the main drivers that change net primary productivity (NPP). We chose the Yiluo River Basin as the study area to investigate the response of NPP to climatic factors in the Yellow River’s middle reaches. The temporal and spatial distribution of net primary productivity and the trend change of slope in the basin from 2000 to 2020 are analyzed. In addition, we analyzed the correlation between the NPP and climatic factors (precipitation and temperature) and the time-lag effect. The results show that 1) the annual average NPP in the basin is 556.4 gC/m2/a, the maximum value that occurred in 2019. Most of the NPP’s mutation points in the basin’s forest appeared in 2004, while the NPP’s mutation points in arable land mostly appeared in 2008 and 2009. 2) The slope trend analysis result of NPP from 2000 to 2020 shows that the NPP in 67.88% of the basin shows a significant increasing trend, 3.8% of the basin shows a significant decrease, and the other area show no significant change. 3) The correlation analysis between NPP and climatic factors shows a positive correlation between precipitation and NPP in 62.3% of the basin and a positive correlation between air temperature and NPP in 62.5%. The response of NPP to precipitation and temperature in the basin has different degrees of a time-lag effect. The NPP has a time-lag effect on precipitation in 44.8% of the basin, and its mean lag time is 8 days. NPP has a time-lag effect on temperature in 55.7% of the basin, and its mean lag time is 1 day. This study is beneficial to understanding the influence of climatic factor change on vegetation activities in the Yiluo River Basin. Our study illustrates the significance of time lag in analyzing the relationship between NPP and climatic factors. Furthermore, it provides support for scientific vegetation regulation and allocation, as well as adaptation to climate change in areas similar to the Loess Plateau, based on the lag time distribution corresponding to different vegetation types in different regions of the Yiluo River Basin. After that, these areas’ water resources will be fully utilized by vegetation, and ecological restoration could be accelerated.
Study on small coal pillar in gob-side entry driving and control technology of the surrounding rock in a high-stress roadway
Authors: Wang Wen , Wu Yiheng , Lu Xiaowei , Zhang Guangjie 
Published: January 2023

The technology described as gob-side entry driving was adopted in the Zhaogu No. 1 mine to resolve the issues pertinent to mining succession tension, serious roadway deformation, and support difficulties. The key parameters of coal columns must be studied to ensure the stable support effect of along-air tunneling under high stress. A calculation for the vertical stress of a coal pillar is proposed, and the location of the breaking line in the top plate in the hollowed mining zone is determined by considering the breakage attributes of the basic uppermost large structure of the key layer, combined with the internal and external stress fields, and the limit equilibrium zone theories. FLAC3D software is employed to simulate the geological requirements of the mine, the characteristics of vertical stress of the coal pillar, and the surrounding rock of the roadway under the technical plan of leaving a 4.5-m coal pillar. The software is also used to verify and analyze the actual measurements. The outcomes suggest that the basic roof break is located at 2.65 m on the side of the coal pillar in the near mining area, and there is a trapezoidal internal stability region around the coal pillar that can provide lasting and stable support of the roadway. The displacement of the two helpers of the roadway is between 100 and 500 mm, and the displacements of the top and bottom plates are less than 300 mm, which ensures the roadway is surrounded by rock when the high-stress requirements occur. The safety of the roadway is determined under high-stress conditions.
Study on rock mass failure characteristics of double-hole delayed blasting in interbedding based on particle expansion algorithm
Authors: Cui Jianbin , Liu Xuejun , Xie Liangfu , Qian Jiangu 
Published: January 2023

The existence of the interface between soft and hard rock often makes it difficult to control the blasting effect. Studying the influence of structural plane and delayed initiation time on rock blasting characteristics can make the blasting effect more controllable. In this paper, by using the Particle Flow Code (PFC2D) and particle expansion algorithm, the double-hole delayed blasting experiments of soft-hard rock are carried out, and the results are analyzed from the perspectives of fragment gradation, micro contact force and energy field. Results show that: 1) When blasting in hard rock, if the distance between structural plane and blasthole is about two times the radius of crushing area, it will easier to form large area fragments, and the fragments tend to be crushed with the increase of the distance. When the distance is 2–4 times the radius of crushing area, with the increase of delay time, the overall fragment area value increases first and then decreases, and reaches the maximum when the delay time is 4 ms. 2) When the structural plane existing in the rock mass, the delayed initiation will make the contact force become relatively uniform within a certain range. The main direction of contact force will appear in the uneven state of contact force generated by simultaneous or delayed initiation, which is close to the parallel or vertical direction of blasthole connection. 3) When blasting in hard rock, if the distance between the structural plane and the blasthole is greater than about two times the radius of the crushing area, compared with simultaneous blasting, the peak kinetic energy and peak strain energy of delayed blasting will be reduced by about 33% and 46% respectively.
Precipitation trends (1958–2021) on Ammassalik island, south-east Greenland
Authors: van der Schot Jorrit , Abermann Jakob , Silva Tiago , Jensen Caroline Drost , Noël Brice , Schöner Wolfgang 
Published: January 2023

Along with Arctic warming, climate models project a strong increase in Arctic precipitation in the 21st century as well as an increase in the ratio of liquid to total precipitation. In the precipitation-rich region of south-east Greenland, precipitation changes could locally have significant impacts on runoff. However, climate data are sparse in this remote region. This study focuses on improving our understanding of the past precipitation changes on Ammassalik island in south-east Greenland between 1958 and 2021. To assess past changes in air temperature at 2-meter and precipitation, output from a regional polar climate model (RACMO2.3p2) is evaluated with measurements from automatic weather stations in Tasiilaq and on Mittivakkat glacier. In addition, RACMO2.3p2 is used to assess past seasonal changes in air temperature at 2-meter, precipitation amount, precipitation phase and the altitude of the rain/snow boundary. We find that the climate model accurately represents the monthly average observed air temperature at 2-meter. While total precipitation is overestimated, interannual variability of precipitation is properly captured. We report a significant increase of summer temperature at 2-meter of +0.3°C/decade (p&lt;0.01) at Mittivakkat glacier and +0.2°C/decade (p&lt;0.01) in Tasiilaq in 1958–2021. For the subperiod 1990–2019, the trend in annual averages of temperature at 2-meter in Tasiilaq (+0.8°C/decade, p=0.02) corresponds well to known temperature trends on the Greenland Ice Sheet within the same period. On Mittivakkat glacier a significant trend is not detected within this subperiod (+0.2°C/decade, p=0.25). The modelled liquid precipitation ratio on Ammassalik island increased in all summer months (1958–2015) by +2.0/+1.9/+1.8%/decade in June/July/August respectively. In July and August, these trends were stronger at higher elevations. No statistical evidence is found for trends in other seasons. We also identify monthly increases in the altitude of the rain-to-snow boundary (+25/+23/+20 m/decade in July/August/September respectively).
Research on the efficiency of green development of industry in Chinese prefecture-level oil and gas cities based on super-efficient SBM-DEA model and Malmquist index
Authors: Fei Sun , Chongliang Sun , Jie Luo , Yana An , Haiyan Sun 
Published: January 2023

With the proposal of Industrial Green Development Plan (2016–2020), it is particularly urgent to focus on the industrial green development of oil and gas cities, actively promote industrial energy efficiency, reduce pollution emissions, and measure the efficiency of their industrial green development. Based on the actual situation of oil and gas cities, we apply the Super-SBM model to measure the industrial green development efficiency of oil and gas cities in 15 years from 2004 to 2018, analyze the spatial and temporal evolution trends and characteristics of industrial green development efficiency, and also calculate the Malmquist index to dynamically analyze the industrial green development efficiency of oil and gas cities. The results show that the industrial green development efficiency of oil and gas cities as a whole is not high from 2004 to 2018, showing a gentle “W” type fluctuation change. From the spatial dimension, there are significant differences in industrial green development efficiency among oil and gas cities in the east, central and west, with the efficiency value is relatively higher in the west. The total factor productivity of industrial green development is most influenced by the changes of technical efficiency and technological progress. In view of the above problems, it is recommended to broaden green technology innovation channels, increase green technology innovation investment, build a new mechanism for regional synergistic development, and formulate regional graded development strategies.
Efficacy and safety of switching from febuxostat to dotinurad, a novel selective urate reabsorption inhibitor, in hyperuricemic patients with type 2 diabetic kidney disease: Protocol for a single-arm, open-label, prospective, exploratory study
Authors: Osonoi Takeshi , Saito Miyoko , Hosoya Mitsuru , Douguchi Satako , Ofuchi Kensuke , Katoh Makoto 
Published: January 2023

BackgroundDotinurad is a novel uricosuric drug in Japan with selective and potent urate transporter 1 (URAT1) inhibitory activity. This study aims to evaluate the efficacy and safety of dotinurad in hyperuricemic patients with type 2 diabetic kidney disease by comparing serum levels of urate and plasma and urinary levels of indoxyl sulfate excreted via the urate excretion transporter ATP binding cassette subfamily G member 2 (ABCG2), as indices, with baseline levels after switching from febuxostat to dotinurad.MethodsThis single-center, single-arm, open-label, prospective, exploratory study aims to evaluate the effect of switching from febuxostat to dotinurad on serum urate levels and its background factors. The study will include 50 hyperuricemic patients with type 2 diabetic kidney disease and urate levels exceeding 6 mg/dL despite administration of febuxostat 20 mg/day for at least 3 months. The primary outcome is the achievement rate of serum urate levels of ≤6 mg/dL after 24 weeks of treatment with dotinurad at 0.5 mg to a maximum of 4 mg once daily. Secondary outcomes include the changes in serum urate levels, plasma and urinary indoxyl sulfate levels, and renal injury-related markers from baseline to observation points at weeks 4, 12, and 24.DiscussionThe study hypothesizes that switching to dotinurad may reduce the plasma levels of indoxyl sulfate and increase its urinary levels in patients with hyperuricemia. These suggest that dotinurad can potently lower the serum urate level by inhibiting URAT1 without adversely affecting ABCG2. Thus, findings of this study are expected to provide useful insights into the treatment of hyperuricemia associated with type 2 diabetic kidney disease and the discovery of new possibilities for dotinurad.Ethics and DisseminationPrior to the study, its study protocol was scientifically and ethically reviewed and approved by the Japan Physicians Association Clinical Research Review Board (approval number: JPA007-2204-02). In addition, patients who provide written informed consent will participate in the study. The results of this study will be published through submission to a peer-reviewed scientific journal.Clinical trial registrationhttps://jrct.niph.go.jp/en-latest-detail/jRCTs031220080, identifier jRCTs031220080.
Effects of labor induction in obesity with delayed pregnancy: A retrospective study based on Chinese obese primipara
Authors: Liu Shuhua , Song Bing , Liu Dehong , Zheng Chenmin , Wu Xiumei , Wei Zhaolian , Chen Xianxia 
Published: January 2023

ObjectiveTo test the hypothesis that obese primiparous women with an unfavorable cervix in delayed pregnancy may experience a worse induction of labor.Study designIn total, 467 primiparas with poor cervical condition and delayed pregnancy (gestational age [GA]: &gt;40weeks) were divided into an obese primiparas group (body mass index [BMI] &gt;30kg/m2; n=166) and a non-obese primiparas group (BMI &lt; 30kg/m2; (n=301). Labor was induced by various methods, double balloon, dinoprostone inserts, and amniotomy combined with oxytocin depending on the Bishop score. Experimental data were analyzed by Statistical Product Service Solutions (SPSS).ResultsBMI in the obese primiparas group was higher than in the non-obese group (33.91 ± 2.67 versus 24.09 ± 5.78, p&lt;0.001), and there were significant differences in uterine tone and duration of contractions between the two groups in the second stage of labour (p=0.041, p=0.026, respectively).The rate of cesarean section (CS) was significantly higher in the primiparas group (23.49% versus 12.29%; P=0.002). There was a significant difference between the two groups in terms of the duration of time to vaginal delivery (VD) (18h versus 8h; P &lt;0.001) while the duration until VD in the obese primiparas group within 12 hours and 24 hours was significantly longer (P &lt;0.001). After adjusting for possible confounders, caesarean section rates remained high in the obese primiparas women (OR: 2.564;95%CI1.919,3.864;P&lt;0.001). Similarly, after adjusting for the same confounding factors, obese primiparas women increased the duration until VD within 24 h by 3.598 hours.ConclusionObese primiparas with an unfavorable cervix in delayed pregnancy have a significantly higher risk of CS and a longer duration until VD than non-obese primiparas during labor induction.
Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization
Authors: Bai Haowei , Sha Yanwei , Tan Yueqiu , Li Peng , Zhang Yuxiang , Xu Junwei , Xu Shuai , Ji Zhiyong , Wang Xiaobo , Chen Wei , Zhang Jianxiong , Yao Chencheng , Li Zheng , Zhi Erlei 
Published: January 2023

IntroductionOligoasthenoteratozoospermia (OAT) is a major cause of infertility in males. Only a few pathogenic genes of OAT have been clearly identified till now. A large number of OAT-affected cases remain largely unknown.MethodsHere, Whole-exome sequencing (WES) in 725 idiopathic OAT patients was performed. Ejaculated spermatozoa by OAT patients were microinjected into mouse oocytes to estimate fertilization potential. Diff-quick staining and transmission electron microscopy were performed to evaluate sperm morphology and ultrastructure. The protein expression level and localization In vitro were detected by Western Blotting and Immunocytochemistry.ResultsWe identified four X-linked hemizygous deleterious variants of TAF7L—namely, c.1301_1302del;(p.V434Afs*5), c.699G&gt;T;(p.R233S), c.508delA; (p. T170fs), c.719dupA;(p.K240fs) —in five probands. Intracytoplasmic sperm injection (ICSI) were carried out in M1, M2-1and M3 patient's wife. However only M1 patient’s wife became pregnant after embryo transfer. In vitro study demonstrated significantly reduced fertilization ability in patient with TAF7L mutation. The TAF7L mutation let to abnormal sperm head and impaired histone-to protamine exchange. Variant 719dupA (p. K240fs) resulted in producing a truncated TAF7L protein and localized massively within the nucleus. In addition, TAF7L expression were not able to be detected due to variants c.1301_1302del (p. V434Afs*5) and c.508delA (p. T170fs) In vitro.ConclusionOur findings support that TAF7L is one of pathogenic genes of OAT and deleterious mutations in TAF7L may cause impaired histone-to-protamine affected the chromatin compaction of sperm head.
Enhanced enzymolysis and bioethanol yield from tobacco stem waste based on mild synergistic pretreatment
Authors: Gong Jiang-Shi-Qi , Su Jia-En , Cai Jie-Yun , Zou Ling , Chen Yi , Jiang Yong-Lei , Hu Bin-Bin 
Published: January 2023

The use of mild pretreatment conditions can significantly lower the cost of the biorefining process. This study evaluated a mild pretreatment approach for tobacco stem waste using a combination of dilute acid and dilute alkali. By optimizing the pretreatment conditions, we obtained a high reducing sugar concentration at a pretreatment temperature &lt;100°C. Increasing the acid or alkali strength in a single pretreatment step did not always improve the result; instead, the synergistic effect of both pretreatment components was important. To increase the bioethanol titer, a high solid loading, 30%, was used for bioethanol fermentation. Compared with batch fermentation, enzyme feeding with a shorter feeding period (24 h) enhanced the bioethanol production by 4.32%, generating 86.88 g/L bioethanol. The results provide valuable insights into the effects of two-step acid/alkali pretreatment on enzymolysis. The findings suggest that the optimized synergistic pretreatment process is efficient for bioethanol fermentation.
Cell death-related biomarker SLC2A1 has a significant role in prognosis prediction and immunotherapy efficacy evaluation in pan-cancer
Authors: Wang Yuhang , Wang Kai , Zhang Han , Jia Xiaoteng , Li Xin , Sun Shuai , Sun Daqiang 
Published: January 2023

Introduction: SLC2A1, a member of the SLC transporter family, is involved in a variety of cell death modalities and has been found to be associated with the prognosis and immune microenvironment of a variety of tumors. However, there is a lack of systematic and comprehensive studies on the role of SLC2A1 in pan-cancer.Methods: The mRNA, promoter methylation, and protein expression levels of SLC2A1 in pan-cancer were comprehensively evaluated using GEPIA2.0, TIMER2.0, and UALCAN databases. UCSCXenaShiny based on the cancer genomic atlas pan-cancer data and GEPIA2.0 database were used to assess the prognostic significance of SLC2A1 in pan-cancer. Genetic alterations in SLC2A1 were also evaluated using cBioPortal. The relevance of SLC2A1 to immune infiltrating cells in pan-cancer was evaluated using the XCELL algorithm in combination with the TIMER2.0 database. The correlation of SLC2A1 with the efficacy of immune checkpoint blocker (ICB) therapy was evaluated using the tumor immune dysfunction and exclusion (TIDE) score. The correlation of SLC2A1 with numerous immune-related markers was also evaluated using the TISIDB database. The correlation of SLC2A1 with tumor biological function was evaluated at the single-cell level using the CancerSEA database. Finally, the biological function of SLC2A1 was comprehensively evaluated using gene set enrichment analysis (GSEA) and protein interaction networks.Results: SLC2A1 expression is aberrant in a variety of tumors and is strongly associated with the prognosis of several cancers. SLC2A1 is significantly associated with a variety of immune infiltrating cells including CD8+ T cells, myeloid-derived suppressor cells and macrophages in a variety of tumors. Meanwhile, the expression of SLC2A1 significantly correlated with multiple immune-related markers. In addition, SLC2A1 can also predict the effect of immune checkpoint blocker therapy in some tumors. In a functional analysis, SLC2A1 was significantly associated with hypoxia, epithelial-mesenchymal transition, mTORC1 signaling, and multiple metabolic pathways in pan-cancer.Conclusion: Our study systematically and comprehensively summarizes the prognostic significance and immune-related role of SLC2A1 in pan-cancer and reveals the potential mechanism of SLC2A1 in regulating the tumor microenvironment and tumor behavior, providing a new effective pan-applicable biomarker for prognostic prediction and the evaluation of immunotherapeutic strategies for tumors.
The impact of cross-reactive immunity on the emergence of SARS-CoV-2 variants
Authors: Thompson Robin N. , Southall Emma , Daon Yair , Lovell-Read Francesca A. , Iwami Shingo , Thompson Craig P. , Obolski Uri 
Published: January 2023

IntroductionA key feature of the COVID-19 pandemic has been the emergence of SARS-CoV-2 variants with different transmission characteristics. However, when a novel variant arrives in a host population, it will not necessarily lead to many cases. Instead, it may fade out, due to stochastic effects and the level of immunity in the population. Immunity against novel SARS-CoV-2 variants may be influenced by prior exposures to related viruses, such as other SARS-CoV-2 variants and seasonal coronaviruses, and the level of cross-reactive immunity conferred by those exposures.MethodsHere, we investigate the impact of cross-reactive immunity on the emergence of SARS-CoV-2 variants in a simplified scenario in which a novel SARS-CoV-2 variant is introduced after an antigenically related virus has spread in the population. We use mathematical modelling to explore the risk that the novel variant invades the population and causes a large number of cases, as opposed to fading out with few cases.ResultsWe find that, if cross-reactive immunity is complete (i.e. someone infected by the previously circulating virus is not susceptible to the novel variant), the novel variant must be more transmissible than the previous virus to invade the population. However, in a more realistic scenario in which cross-reactive immunity is partial, we show that it is possible for novel variants to invade, even if they are less transmissible than previously circulating viruses. This is because partial cross-reactive immunity effectively increases the pool of susceptible hosts that are available to the novel variant compared to complete cross-reactive immunity. Furthermore, if previous infection with the antigenically related virus assists the establishment of infection with the novel variant, as has been proposed following some experimental studies, then even variants with very limited transmissibility are able to invade the host population.DiscussionOur results highlight that fast assessment of the level of cross-reactive immunity conferred by related viruses against novel SARS-CoV-2 variants is an essential component of novel variant risk assessments.