bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Molecular Imaging Find a Path to Navigate Evolving Breast Cancer Treatments?
Authors: Linden Hannah M. , Mankoff David A. 
Published: March 2023

Summary[18F]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker. Like IHC, FES positivity predicts clinical benefit of endocrine therapy. In addition, FES measures the target activity in endocrine agent drug development. A recent study found that whole body tumor heterogeneity of expression predicts clinical benefit, and serial FES monitors estrogen receptor blockade and posttreatment release.See related article by Iqbal et al., p. 2075
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis
Authors: Cai Wenbin , Liu Le , Shi Xuelian , Liu Yanan , Wang Jin , Fang Xuan , Chen Zhipeng , Ai Ding , Zhu Yi , Zhang Xu 
Published: March 2023

Background:
Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to myocardial cell loss and fibrosis. Prevention of cell death is important to protect cardiac function after I/R injury. The process of reperfusion can lead to multiple types of cardiomyocyte death, including necrosis, apoptosis, autophagy, and ferroptosis. However, the time point at which the various modes of cell death occur after reperfusion injury and the mechanisms underlying ferroptosis regulation in cardiomyocytes are still unclear.

Methods:
Using a left anterior descending coronary artery ligation mouse model, we sought to investigate the time point at which the various modes of cell death occur after reperfusion injury. To discover the key molecules involved in cardiomyocyte ferroptosis, we performed a metabolomics study. Loss/gain-of-function approaches were used to understand the role of 15-lipoxygenase (Alox15) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Pgc1α) in myocardial I/R injury.

Results:
We found that apoptosis and necrosis occurred in the early phase of I/R injury, and that ferroptosis was the predominant form of cell death during the prolonged reperfusion. Metabolomic profiling of eicosanoids revealed that Alox15 metabolites accumulated in ferroptotic cardiomyocytes. We demonstrated that Alox15 expression was specifically increased in the injured area of the left ventricle below the suture and colocalized with cardiomyocytes. Furthermore, myocardial-specific knockout of Alox15 in mice alleviated I/R injury and restored cardiac function. 15-Hydroperoxyeicosatetraenoic acid (15-HpETE), an intermediate metabolite derived from arachidonic acid by Alox15, was identified as a trigger for cardiomyocyte ferroptosis. We explored the mechanism underlying its effects and found that 15-HpETE promoted the binding of Pgc1α to the ubiquitin ligase ring finger protein 34, leading to its ubiquitin-dependent degradation. Consequently, attenuated mitochondrial biogenesis and abnormal mitochondrial morphology were observed. ML351, a specific inhibitor of Alox15, increased the protein level of Pgc1α, inhibited cardiomyocyte ferroptosis, protected the injured myocardium, and caused cardiac function recovery.

Conclusions:
Together, our results established that Alox15/15-HpETE–mediated cardiomyocyte ferroptosis plays an important role in prolonged I/R injury.
Transcriptomics-Based Subphenotyping of the Human Placenta Enabled by Weighted Correlation Network Analysis in Early-Onset Preeclampsia With and Without Fetal Growth Restriction
Authors: Ackerman William E. , Buhimschi Catalin S. , Brown Thomas L. , Zhao Guomao , Summerfield Taryn L. , Buhimschi Irina A. 
Published: March 2023

Background:
Placental disorders contribute to pregnancy complications, including preeclampsia and fetal growth restriction (FGR), but debate regarding their specific pathobiology persists. Our objective was to apply transcriptomics with weighted gene correlation network analysis to further clarify the placental dysfunction in these conditions.

Methods:
We performed RNA sequencing with weighted gene correlation network analysis using human placental samples (n=30), separated into villous tissue and decidua basalis, and clinically grouped as follows: (1) early-onset preeclampsia (EOPE)+FGR (n=7); (2) normotensive, nonanomalous preterm FGR (n=5); (2) EOPE without FGR (n=8); (4) spontaneous idiopathic preterm birth (n=5) matched for gestational age; and (5) uncomplicated term births (n=5). Our data was compared with RNA sequencing data sets from public databases (GSE114691, GSE148241, and PRJEB30656; n=130 samples).

Results:

We identified 14 correlated gene modules in our specimens, of which most were significantly correlated with birthweight and maternal blood pressure. Of the 3 network modules consistently predictive of EOPE±FGR across data sets, we prioritized a coexpression gene group enriched for hypoxia-response and metabolic pathways for further investigation. Cluster analysis based on transcripts from this module and the glycolysis/gluconeogenesis metabolic pathway consistently distinguished a subset of EOPE±FGR samples with an expression signature suggesting modified tissue bioenergetics. We demonstrated that the expression ratios of
LDHA
/
LDHB
and
PDK1
/
GOT1
could be used as surrogate indices for the larger panels of genes in identifying this subgroup.

Conclusions:
We provide novel evidence for a molecular subphenotype consistent with a glycolytic metabolic shift that occurs more frequently but not universally in placental specimens of EOPE±FGR.
Stable Income, Stable Family
Authors: Lindo Jason M. , Regmi Krishna , Swensen Isaac D. 
Published: March 2023

Abstract
We document the effect of unemployment insurance generosity on divorce and fertility using an identification strategy that leverages state-level changes in maximum benefits over time and comparisons across workers who have been laid off and those that have not been laid off. The results indicate that higher maximum benefit levels mitigate the effects of layoffs. In particular, they mitigate increases in divorce associated with men's layoffs; increases in separations associated with women's layoffs; reductions in fertility associated with men's layoffs; and increases in fertility associated with women's layoffs.
Evaluating Policies Early in a Pandemic: Bounding Policy Effects with Nonrandomly Missing Data
Authors: Callaway Brantly , Li Tong 
Published: March 2023

Abstract
During the early part of the Covid-19 pandemic, national and local governments introduced a number of policies to combat the spread of Covid-19. In this paper, we propose a new approach to bound the effects of such early-pandemic policies on Covid-19 cases and other outcomes while dealing with complications arising from (i) limited availability of Covid-19 tests, (ii) differential availability of Covid-19 tests across locations, and (iii) eligibility requirements for individuals to be tested. We use our approach study the effects of Tennessee's expansion of Covid-19 testing early in the pandemic and find that the policy decreased Covid-19 cases.
Selecting Top Bureaucrats: Admission Exams and Performance in Brazil
Authors: Dahis Ricardo , Schiavon Laura , Scot Thiago 
Published: March 2023

Abstract
In the absence of strong incentives, public service delivery is crucially dependent on bureaucrat selection. Despite wide adoption by governments, it is unclear whether civil service examinations reliably select for job performance. We investigate this question focusing on state judges in Brazil. Exploring monthly data on judicial output and cross-court movement, we estimate that judges account for at least 23% of the observed variation in the number of cases disposed. With novel data on admission examinations, we show that judges with higher grades perform better than lower-ranked peers. Our results suggest competitive examinations can be an effective way to screen candidates.
Announcement-Specific Decompositions of Unconventional Monetary Policy Shocks and Their Effects
Authors: Lewis Daniel J. 
Published: March 2023

Abstract
I propose to identify announcement-specific decompositions of asset price changes into monetary policy shocks exploiting heteroskedasticity in intraday data, accommodating both changes in the nature of shocks and the state of the economy across announcements. I compute decompositions with respect to Fed Funds, forward guidance, asset purchase, and Fed information shocks from January 1996 to December 2019. The decompositions illustrate which announcements of unconventional policy measures had significant effects during the Great Recession. Overall, forward guidance and asset purchases have significant effects on yields, spreads, equities, and uncertainty, but the effects of monetary policy vary over time, particularly asset purchases.
Influence-Seeking in U.S. Corporate Elites' Campaign Contribution Behavior
Authors: Teso Edoardo 
Published: March 2023

Abstract
I show that U.S. corporate elites use contributions to political campaigns as a tool of political influence by leveraging a new panel on the contributions to members of U.S. Congress (MCs) from 401,557 corporate leaders of 14,807 U.S. corporations over 1999-2018. Donations increase by 11% when a politician is assigned to a committee dealing with policy issues relevant to a corporate leader's company. The effect is driven by donations to MCs with the greatest power in the committees. I estimate that, absent an influence motive, donations from corporate leaders during this period would have been lower by $20 million.
Opposing effects of vigilance and foraging on escape behaviour in hooded crows
Authors: Novčić Ivana 
Published: March 2023

Abstract
Escape represents an important component of animals’ antipredator behaviour entailing both benefits and costs dependent on a moment an animal flees upon predator’s approach. In this study, I examined how the level of vigilance and foraging activity affected escape decision in the urban hooded crow Corvus cornix, predicting that alert distance (AD) and flight initiation distance (FID) should be positively affected by the level of vigilance and negatively affected by foraging activity, whereas buffer distance (BD) should be negatively affected by the level of vigilance and positively affected by foraging activity. Using LMMs it was shown that percent of time crows allocated to vigilance was positively correlated with AD and FID, whereas foraging activity of crows had negative impact on AD and FID. In addition, both AD and FID were positively related to starting distance (SD), while AD was also positively influenced by tree coverage. BD was positively affected by foraging activity and AD. This study demonstrated that more vigilant birds detected predators earlier, which is in accordance with the major function of vigilance. Also, it was shown that foraging crows delayed their escape, once the predator has been detected, as benefits of delayed flight, such as feeding on a profitable food item or within a profitable patch, may outweigh costs, which is consistent with the optimal escape theory.
Small Spaces and Multiple Contexts: Nootka Sound’s Global Locality 1774–1794
Authors: Berg Maxine 
Published: March 2023

Abstract
This article conveys the power of place in global history through the multiple perceptions of space and possession in one small remote locality – Nootka Sound on the Northwest coast of Vancouver Island, British Columbia. This space was, for a brief period between the 1770s and 1790s, connected with many parts of the world. Microhistorical methodologies applied to the texts of traders and explorers and turned to the study of a locality such as Nootka Sound reveal the close global connections of agents and events and help us to challenge the frameworks of global history.
Introduction: Global Microhistory of the Local and the Global
Authors: Berg Maxine 
Published: March 2023

Abstract
This Special Issue addresses recent discussions of the potential historical approach of “global microhistory.” The six articles gathered here are based in the study of Africa, South Asia, the northwest Pacific coast of North America, and Europe, as well as in the recent methodologies of global history and microhistory. They focus on methodology and on the empirical study of ways of connecting local spaces and networks with global dynamics. All are set in social and economic formations that have too often been bypassed in the cultural and literary approaches of some microhistory and the political approaches of some global history.
Feminist Ecological Pacifism and Care in the Anthropocene
Authors: Väyrynen Tarja 
Published: March 2023

Abstract
The shared materiality of all living entities on the planet and their connectivity becomes an invitation to rethink pacifism to explore new forms of being in the world. This paper asks how we can think about the environment, violence, and pacifism when the older conceptions of violence do not capture all of its complex and interrelational features in the Anthropocene. Feminist new materialism moves away from anthropocentrism and offers an alternative trajectory for thinking about the environment and practicing pacifism in light of environmental, slow, and epistemic violence. It emphasises that since we are always already part of the world and thereby ethically responsible for the intra-actions we share with all beings, we bear a ‘response-ability’ (Barad 2012, 206–207). As a radical theory and practice, feminist environmental pacifism makes visible the violent socio-political complexities of human – nature connections and suggests caring about earthly co-existence with all beings.
A Time – and a Project – for Pacifism and Nonviolence Studies
Authors: Cady Duane L. 
Published: March 2023

Abstract
Why is it time to take pacifism and nonviolence studies more seriously? I attempt to show that pacifism and nonviolence studies are not only helpful but are necessary to understand and root out a presumption about violence that has persisted throughout human history, a presumption through which the vast majority of humans on earth experience our world. I am referring to the seemingly universal human inclination to take violence for granted as a necessary – even moral – means for human thriving, safety, and progress. We are told that it is human nature to fight or flee danger. In what follows I explore the possibility that fighting and fleeing may not be natural but cultural, and that they may not exhaust human options in response to danger. I then discuss the presumption of violence and consider the role of pacifist and nonviolence studies in analyzing and even deconstructing it by exploring a reasonable alternative view.
Pacifism and Nonviolence: Discerning the Contours of an Emerging Multidisciplinary Research Agenda
Authors: Christoyannopoulos Alexandre 
Published: March 2023

Abstract
Pacifism and nonviolence have separable foci and origins, yet also share important similarities, and their respective histories are mutually imbricated. Both have, furthermore, been attracting growing scholarly interest. However, that scholarship has so far been scattered in disparate sub-disciplinary debates and specialist publications. The time has come for an ambitious multidisciplinary agenda to coordinate research on topics including: the varieties of approaches to nonviolence and pacifism; accusations against pacifism; tensions between pacifism and nonviolence; theories and practices outside the Global North; the multiple consequences of violence; violence and nonviolence in political thought; the relationship between violence/nonviolence and gender, race, and other social identities; the religious roots of pacifism and nonviolence; the place of violence and nonviolence in popular culture; practical nonviolent policies of governance; predominant assumptions concerning violence in ir; the threshold characteristics of ‘violence’; and methodological challenges in the study and pedagogy of nonviolence and pacifism.
The Critical Challenge of Pacifism and Nonviolent Resistance Then and Now: From Sand Creek, and Ukraine to Climate Change
Authors: Crawford Neta C. 
Published: March 2023

Abstract
Pacifism and nonviolence are ethical, political, and practical policy/strategy arguments that articulate alternative visions of politics, security, and social relations. They bring different perspectives to the problem of aggression and resistance to it, such as in the Ukraine war, and to the longer term climate crisis. Because pacifism and the potential efficacy of nonviolent action challenge militarist assertions about the morality and effectiveness of military force, they provide tools for an effective critique of the war system, not only at the fringes where one is debating policy alternatives, but at the core. Research should explore the spectrum of pacifism and nonviolence—from peaceful societies to nonviolent direct action and defensive defense. The non-participation of US soldiers in the Sand Creek Massacre illustrates both the bravery and limits of non-participation and the potential importance of the philosophical links between pacifism and cognate movements in shaping the motivation to resist violence.
A Gridded Monthly Precipitation Merged Rain Gauge and Satellite Analysis Dataset for the Tian Shan Range between 1981 and 2019
Authors: Zhao Chuancheng , Yao Shuxia , Ding Yongjian , Zhao Qiudong 
Published: March 2023

Abstract
An accurate and reliable precipitation product on regular grids is essential for understanding trends and variability within climate studies, for weather forecasting, and in hydrology and agrometeorology applications. However, the construction of high-resolution spatiotemporal precipitation grid products is challenging for complex terrain with sparse rain gauge networks and when only coarse spatial resolutions of satellite data are available. The objective of this study was to consequently provide a practical method to create a grid precipitation product by merging accurate quantitative observations from weather stations with continuous spatial information and from a satellite-based estimate product. The new gridded precipitation product exhibits a monthly temporal resolution and a spatial resolution of 0.01° for the Tian Shan range, extending back to 1981. To overcome the limitation of low densities and sparse distributions of meteorological stations in the complex terrain of the Tian Shan, a suitable interpolation of Australian National University Spline (ANUSPLIN) was used to interpolate grid precipitation based on in situ data. The interpolation grid precipitation was then merged with the satellite precipitation product developed by the U.S. Geological Survey and the Climate Hazards Group. After evaluation and validation using withheld stations and comparison to reference datasets, the result indicated that the merged product exhibits considerable promise for application in complex terrain. The method can be widely applied and is expected to construct precipitation products with high spatial and temporal resolution by merging multiple precipitation data sources.

Significance Statement
The purpose of this study is to construct a gridded precipitation dataset by merging the interpolation precipitation based on in situ observation and a satellite precipitation product in arid mountain regions. This is important because gridded precipitations are essential to the evaluation of climate model output and detection of trends in mean climate and climate extremes. Our results present a guide on merging frameworks to construct precipitation datasets used multisource data sources for regions with complex topography, precipitation scarcity, and ungauged and sparse collection.
Propagation Diversity of Quasi-Biweekly Oscillation of Summer Precipitation in the Middle and Lower Reaches of the Yangtze River
Authors: Yao Suxiang , Liu Yishan , Huang Qian 
Published: March 2023

Abstract
Summer precipitation in the middle and lower reaches of the Yangtze River (MLYR) has obvious characteristics of intraseasonal oscillation, but there are different inferences about its propagation. Based on observed precipitation and ERA5 data, the propagation diversity of summer quasi-biweekly precipitation in the MLYR is analyzed. The results show that summer precipitation in the MLYR has obvious quasi-biweekly oscillation (QBWO) characteristics, and precipitation QBWO events can be classified into three categories: southward, northward, and local oscillation events. The frequency of southward events is significantly higher than that of northward or local oscillation events. For southward events, a wave train is observed in the mid–high latitudes and propagates southward in East Asia. The northward and local oscillation events are closely related to the QBWO of the northwest Pacific in low latitudes. The meridional asymmetry of quasi-biweekly divergence and background wind is responsible for the diversity of QBWO propagation. Quasi-biweekly convergence is usually located on the south of the quasi-biweekly cyclone, so the convergence interacts with geostrophic vorticity to guide the quasi-biweekly cyclone to move southward; in the southerly basic flow, north of the quasi-biweekly cyclone is positive relative vorticity advection, which leads the quasi-biweekly cyclone to move northward. Therefore, quasi-biweekly disturbances originating from north of the MLYR, with weak basic wind, mainly move southward under the influence of convergence. However, quasi-biweekly disturbances at low latitudes move northward under the guidance of relative vorticity advection due to the strong basic flow. A disturbance originating from the MLYR presents local oscillation under the coaction of quasi-biweekly relative vorticity advection and divergence.
A Submonthly Scale Causal Relation between Snow Cover and Surface Air Temperature over the Autumnal Eurasian Continent
Authors: Komatsu Kensuke K. , Takaya Yuhei , Toyoda Takahiro , Hasumi Hiroyasu 
Published: March 2023

Abstract
Snow cover (SC) is an important contributor to atmospheric predictability on subseasonal to seasonal time scales. This paper evaluates the submonthly scale cause-and-effect relationship between SC and surface air temperature (SAT) in Eurasia, which has been typically overlooked in previous statistical analyses of subseasonal to seasonal atmospheric predictability. We focus on the November east–west dipolar SC pattern, a dominant large-scale SC phenomenon. We use an information flow analysis, based on information theory, to infer causal relations not revealed by conventional correlation analysis. This analysis indicates a one-way causality from SAT to SC around the west pole (Europe) in boreal autumn (November), implying that SC has little influence on the time evolution of SAT. In contrast, causality from SC to SAT is significant around the east pole (the Mongolian Plateau). An atmospheric model experiment suggests that the SAT response to SC can persist for a month via snow–albedo feedback, although the response of the upper atmosphere in the model is small. Furthermore, the subseasonal hindcasts show that the contribution of SC may affect the predictability of SAT for up to four weeks around the east pole. We suggest that the geographical and climatological atmospheric conditions are favorable for generating a positive albedo feedback as a “hotspot” of SC–SAT coupling around the east pole in autumn. The agreement of our causality analysis with other analytical and modeling approaches underscores the cause-and-effect relationship between SC and SAT and its contribution to the subseasonal predictability over autumnal Eurasia.