bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning Approaches: Cross-Cultural Differences (Spain–Argentina) and Academic Achievement in College Students
Authors: Freiberg-Hoffmann Agustín , Romero-Medina Agustín , López-Fernández Beatriz , Fernández-Liporace Mercedes 
Published: June 2023

Abstract
Learning approaches describe the students’ degree of cognitive commitment to learning in diverse types of academic tasks and educational environments. Even though from a micro-level perspective different profiles of approaches have been identified in high-achievement undergraduates attending several majors, such profiles have not been examined from a macro-level approach in terms of distinct educational cultures. Therefore, the research involved two studies conducted on undergraduates from Argentina and Spain: The first one was aimed at analyzing the psychometric features of the Approaches and Study Skills Inventory for Students (ASSIST) whereas the second was focused on examining the learning approaches profiles of high and low achievers attending the same major (Psychology) in two different educational cultures (Spain and Argentina). The scale’s original internal structure, examined on a sample of 400 participants (50% Spanish), was verified except for one item, which was fatherly eliminated. The resulting structure was tested and proven verified in a new sample (N = 1,334; 58.3% Spanish) by confirmatory factor analysis, factorial invariance, and internal consistency studies. External validity evidence was examined as well. Additionally, norms to be used in the professional field were calculated.
Profiles of learning approaches by academic achievement from each country were examined by latent class analysis. In both cases, high achievers reported higher and more frequent use of the Deep and Strategic approaches and lower and less frequent usage of the Surface one. Further studies should replicate these analyses in undergraduates attending other majors in order to test the hypothesis sustaining these findings’ generalization.
Goal Adjustment and Subjective Well-Being in Adulthood
Authors: Leipold Bernhard , Loepthien Tim , Loidl Barbara , Saalwirth Christina 
Published: June 2023

Abstract: Studies on motivational development in adulthood often use self-report measures to examine the relationship between aspects of goal adjustment (accommodative coping, detachment from goals, goal pursuit), and well-being. Most have focused on how tendencies in general goal adjustment regulate subjective well-being. The present study examined the longitudinal associations between well-being (life satisfaction, positive affect) and goal adjustment and between accommodative coping and goal pursuit. Variables were assessed in a three-wave longitudinal study (intervals of about 1 year) with a sample of N = 305 adults aged 30–78 years. Longitudinal effects were computed with latent growth models. Results showed that increases in well-being predicted increases in goal pursuit and accommodative coping (positive reappraisal/personal growth, acceptance, reorientation). Increases in accommodative coping predicted increases in goal pursuit and goal detachment. The initial level of goal pursuit predicted decreases in accommodative coping, and the initial level of accommodative coping predicted increases in well-being. In sum, the study demonstrated that subjective well-being is a resource for goal pursuit and accommodative coping, but also that an increase in well-being profits from both. The study provided evidence for the growing relationships of goal adjustment facets.
A Simulation of Artificial Neutral Gas‐Dust Plasma in the Ionosphere
Authors: Feng Jie , Guo Lixin , Xu Bin , Wu Jian , Li Haiying , Liang Yonggan , Xu Zhengwen , Zhao Haisheng , Ma Zhengzheng , Wang Cheng 
Published: June 2023

AbstractDusty plasma is generally defined as a plasma system containing a large number of nano‐ or micron‐sized dust particles. Its plasma properties and propagation properties of wave travel through it is of great scientific significance to the understanding of many fundamental problems in space physics and astrophysics. Based on previous studies on rocket exhaust and Polar Mesosphere Summer Echoes, fluid mechanics and dust microphysics are combined to simulate the ionospheric plasma structure generated by neutral gases and charged aerosols using fluid theory and kinetic theory. The Total Electron Content of the in‐situ detection beacon is simulated and compared with the experimental phenomenon given in Charged Aerosol Release Experiment by Bernhardt et al. The ray tracing algorithm is used to simulate the path deflection of the radio wave when it passes through the artificial disturbance area generated by the gas‐solid mixture, and the simulation results of ionosonde and analysis are given. Since the neutral gas expands substantially isotropically after being released, the resulting depleted structure is an approximately isotropic sphere, or an acorn‐like structure. The solid particles are constrained by the nozzle, and particles will distribute within a spray angle, and the depletion structure will appear as a “broom‐like” or “cone‐like” structure. If the size of dust particles is small enough, the particle movement will be restricted by the geomagnetic field, resulting in a “squid‐like” ionospheric structure. Because of the fishtail‐like sharp boundary, radio waves passing through it are deflected in a specific path, which is markedly different from the effect of pure neutral gas injected into the ionosphere.
A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer
Authors: Meng Delong , Zhao Xin , Yang Yu Chi , Navickas Albertas , Helland Ciara , Goodarzi Hani , Singh Mallika , Bandyopadhyay Sourav 
Published: June 2023

AbstractActivation of the PI3K-mTOR pathway is central to breast cancer pathogenesis including resistance to many targeted therapies. The mTOR kinase forms two distinct complexes, mTORC1 and mTORC2, and understanding which is required for the survival of malignant cells has been limited by tools to selectively and completely impair either subcomplex. To address this, we used RMC-6272, a bi-steric molecule with a rapamycin-like moiety linked to an mTOR active-site inhibitor that displays >25-fold selectivity for mTORC1 over mTORC2 substrates. Complete suppression of mTORC1 by RMC-6272 causes apoptosis in ER+/HER2− breast cancer cell lines, particularly in those that harbor mutations in PIK3CA or PTEN, due to inhibition of the rapamycin resistant, mTORC1 substrate 4EBP1 and reduction of the pro-survival protein MCL1. RMC-6272 reduced translation of ribosomal mRNAs, MYC target genes, and components of the CDK4/6 pathway, suggesting enhanced impairment of oncogenic pathways compared to the partial mTORC1 inhibitor everolimus. RMC-6272 maintained efficacy in hormone therapy-resistant acquired cell lines and patient-derived xenografts (PDX), showed increased efficacy in CDK4/6 inhibitor treated acquired resistant cell lines versus their parental counterparts, and was efficacious in a PDX from a patient experiencing resistance to CDK4/6 inhibition. Bi-steric mTORC1-selective inhibition may be effective in overcoming multiple forms of therapy-resistance in ER+ breast cancers.
Telomere DNA length regulation is influenced by seasonal temperature differences in short-lived but not in long-lived reef-building corals
Authors: Rouan Alice , Pousse Melanie , Djerbi Nadir , Porro Barbara , Bourdin Guillaume , Carradec Quentin , Hume Benjamin CC. , Poulain Julie , Lê-Hoang Julie , Armstrong Eric , Agostini Sylvain , Salazar Guillem , Ruscheweyh Hans-Joachim , Aury Jean-Marc , Paz-García David A. , McMinds Ryan , Giraud-Panis Marie-Josèphe , Deshuraud Romane , Ottaviani Alexandre , Morini Lycia Die , Leone Camille , Wurzer Lia , Tran Jessica , Zoccola Didier , Pey Alexis , Moulin Clémentine , Boissin Emilie , Iwankow Guillaume , Romac Sarah , de Vargas Colomban , Banaigs Bernard , Boss Emmanuel , Bowler Chris , Douville Eric , Flores Michel , Reynaud Stéphanie , Thomas Olivier P. , Troublé Romain , Thurber Rebecca Vega , Planes Serge , Allemand Denis , Pesant Stephane , Galand Pierre E. , Wincker Patrick , Sunagawa Shinichi , Röttinger Eric , Furla Paola , Voolstra Christian R. , Forcioli Didier , Lombard Fabien , Gilson Eric 
Published: June 2023

AbstractTelomeres are environment-sensitive regulators of health and aging. Here,we present telomere DNA length analysis of two reef-building coral genera revealing that the long- and short-term water thermal regime is a key driver of between-colony variation across the Pacific Ocean. Notably, there are differences between the two studied genera. The telomere DNA lengths of the short-lived, more stress-sensitive Pocillopora spp. colonies were largely determined by seasonal temperature variation, whereas those of the long-lived, more stress-resistant Porites spp. colonies were insensitive to seasonal patterns, but rather influenced by past thermal anomalies. These results reveal marked differences in telomere DNA length regulation between two evolutionary distant coral genera exhibiting specific life-history traits. We propose that environmentally regulated mechanisms of telomere maintenance are linked to organismal performances, a matter of paramount importance considering the effects of climate change on health.
Diversity of the Pacific Ocean coral reef microbiome
Authors: Galand Pierre E. , Ruscheweyh Hans-Joachim , Salazar Guillem , Hochart Corentin , Henry Nicolas , Hume Benjamin C. C. , Oliveira Pedro H. , Perdereau Aude , Labadie Karine , Belser Caroline , Boissin Emilie , Romac Sarah , Poulain Julie , Bourdin Guillaume , Iwankow Guillaume , Moulin Clémentine , Armstrong Eric J. , Paz-García David A. , Ziegler Maren , Agostini Sylvain , Banaigs Bernard , Boss Emmanuel , Bowler Chris , de Vargas Colomban , Douville Eric , Flores Michel , Forcioli Didier , Furla Paola , Gilson Eric , Lombard Fabien , Pesant Stéphane , Reynaud Stéphanie , Thomas Olivier P. , Troublé Romain , Zoccola Didier , Voolstra Christian R. , Thurber Rebecca Vega , Sunagawa Shinichi , Wincker Patrick , Allemand Denis , Planes Serge 
Published: June 2023

AbstractCoral reefs are among the most diverse ecosystems on Earth. They support high biodiversity of multicellular organisms that strongly rely on associated microorganisms for health and nutrition. However, the extent of the coral reef microbiome diversity and its distribution at the oceanic basin-scale remains to be explored. Here, we systematically sampled 3 coral morphotypes, 2 fish species, and planktonic communities in 99 reefs from 32 islands across the Pacific Ocean, to assess reef microbiome composition and biogeography. We show a very large richness of reef microorganisms compared to other environments, which extrapolated to all fishes and corals of the Pacific, approximates the current estimated total prokaryotic diversity for the entire Earth. Microbial communities vary among and within the 3 animal biomes (coral, fish, plankton), and geographically. For corals, the cross-ocean patterns of diversity are different from those known for other multicellular organisms. Within each coral morphotype, community composition is always determined by geographic distance first, both at the island and across ocean scale, and then by environment. Our unprecedented sampling effort of coral reef microbiomes, as part of theTaraPacific expedition, provides new insight into the global microbial diversity, the factors driving their distribution, and the biocomplexity of reef ecosystems.
Transposon signatures of allopolyploid genome evolution
Authors: Session Adam M. , Rokhsar Daniel S. 
Published: June 2023

AbstractHybridization brings together chromosome sets from two or more distinct progenitor species. Genome duplication associated with hybridization, or allopolyploidy, allows these chromosome sets to persist as distinct subgenomes during subsequent meioses. Here, we present a general method for identifying the subgenomes of a polyploid based on shared ancestry as revealed by the genomic distribution of repetitive elements that were active in the progenitors. This subgenome-enriched transposable element signal is intrinsic to the polyploid, allowing broader applicability than other approaches that depend on the availability of sequenced diploid relatives. We develop the statistical basis of the method, demonstrate its applicability in the well-studied cases of tobacco, cotton, andBrassica napus, and apply it to several cases: allotetraploid cyprinids, allohexaploid false flax, and allooctoploid strawberry. These analyses provide insight into the origins of these polyploids, revise the subgenome identities of strawberry, and provide perspective on subgenome dominance in higher polyploids.
Host transcriptomic plasticity and photosymbiotic fidelity underpin Pocillopora acclimatization across thermal regimes in the Pacific Ocean
Authors: Armstrong Eric J. , Lê-Hoang Julie , Carradec Quentin , Aury Jean-Marc , Noel Benjamin , Hume Benjamin C. C. , Voolstra Christian R. , Poulain Julie , Belser Caroline , Paz-García David A. , Cruaud Corinne , Labadie Karine , Da Silva Corinne , Moulin Clémentine , Boissin Emilie , Bourdin Guillaume , Iwankow Guillaume , Romac Sarah , Agostini Sylvain , Banaigs Bernard , Boss Emmanuel , Bowler Chris , de Vargas Colomban , Douville Eric , Flores Michel , Forcioli Didier , Furla Paola , Galand Pierre E. , Gilson Eric , Lombard Fabien , Pesant Stéphane , Reynaud Stéphanie , Sullivan Matthew B. , Sunagawa Shinichi , Thomas Olivier P. , Troublé Romain , Thurber Rebecca Vega , Zoccola Didier , Planes Serge , Allemand Denis , Wincker Patrick 
Published: June 2023

AbstractHeat waves are causing declines in coral reefs globally. Coral thermal responses depend on multiple, interacting drivers, such as past thermal exposure, endosymbiont community composition, and host genotype. This makes the understanding of their relative roles in adaptive and/or plastic responses crucial for anticipating impacts of future warming. Here, we extracted DNA and RNA from 102 Pocillopora colonies collected from 32 sites on 11 islands across the Pacific Ocean to characterize host-photosymbiont fidelity and to investigate patterns of gene expression across a historical thermal gradient. We report high host-photosymbiont fidelity and show that coral and microalgal gene expression respond to different drivers. Differences in photosymbiotic association had only weak impacts on host gene expression, which was more strongly correlated with the historical thermal environment, whereas, photosymbiont gene expression was largely determined by microalgal lineage. Overall, our results reveal a three-tiered strategy of thermal acclimatization in Pocillopora underpinned by host-photosymbiont specificity, host transcriptomic plasticity, and differential photosymbiotic association under extreme warming.
Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice
Authors: Persaud Avinash K. , Bernier Matthew C. , Massey Michael A. , Agrawal Shipra , Kaur Tejinder , Nayak Debasis , Xie Zhiliang , Weadick Brenna , Raj Ruchika , Hill Kasey , Abbott Nicole , Joshi Arnav , Anabtawi Nadeen , Bryant Claire , Somogyi Arpad , Cruz-Monserrate Zobeida , Amari Foued , Coppola Vincenzo , Sparreboom Alex , Baker Sharyn D. , Unadkat Jashvant D. , Phelps Mitch A. , Govindarajan Rajgopal 
Published: June 2023

AbstractConcentrative nucleoside transporters (CNTs) are active nucleoside influx systems, but their in vivo roles are poorly defined. By generating CNT1 knockout (KO) mice, here we identify a role of CNT1 in the renal reabsorption of nucleosides. Deletion of CNT1 in mice increases the urinary excretion of endogenous pyrimidine nucleosides with compensatory alterations in purine nucleoside metabolism. In addition, CNT1 KO mice exhibits high urinary excretion of the nucleoside analog gemcitabine (dFdC), which results in poor tumor growth control in CNT1 KO mice harboring syngeneic pancreatic tumors. Interestingly, increasing the dFdC dose to attain an area under the concentration-time curve level equivalent to that achieved by wild-type (WT) mice rescues antitumor efficacy. The findings provide new insights into how CNT1 regulates reabsorption of endogenous and synthetic nucleosides in murine kidneys and suggest that the functional status of CNTs may account for the optimal action of pyrimidine nucleoside analog therapeutics in humans.
Understanding and design of metallic alloys guided by phase-field simulations
Authors: Zhao Yuhong 
Published: June 2023

AbstractPhase-field method (PFM) has become a mainstream computational method for predicting the evolution of nano and mesoscopic microstructures and properties during materials processes. The paper briefly reviews latest progresses in applying PFM to understanding the thermodynamic driving forces and mechanisms underlying microstructure evolution in metallic materials and related processes, including casting, aging, deformation, additive manufacturing, and defects, etc. Focus on designing alloys by integrating PFM with constitutive relations and machine learning. Several examples are presented to demonstrate the potential of integrated PFM in discovering new multi-scale phenomena and high-performance alloys. The article ends with prospects for promising research directions.
Genetically adjusted PSA levels for prostate cancer screening
Authors: Kachuri Linda , Hoffmann Thomas J. , Jiang Yu , Berndt Sonja I. , Shelley John P. , Schaffer Kerry R. , Machiela Mitchell J. , Freedman Neal D. , Huang Wen-Yi , Li Shengchao A. , Easterlin Ryder , Goodman Phyllis J. , Till Cathee , Thompson Ian , Lilja Hans , Van Den Eeden Stephen K. , Chanock Stephen J. , Haiman Christopher A. , Conti David V. , Klein Robert J. , Mosley Jonathan D. , Graff Rebecca E. , Witte John S. 
Published: June 2023

Abstract
Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer-related PSA variation has potential to improve screening utility. In this study, we discovered 128 genome-wide significant associations (P < 5 × 10−8) in a multi-ancestry meta-analysis of 95,768 men and developed a PSA polygenic score (PGSPSA) that explains 9.61% of constitutive PSA variation. We found that, in men of European ancestry, using PGS-adjusted PSA would avoid up to 31% of negative prostate biopsies but also result in 12% fewer biopsies in patients with prostate cancer, mostly with Gleason score <7 tumors. Genetically adjusted PSA was more predictive of aggressive prostate cancer (odds ratio (OR) = 3.44, P = 6.2 × 10−14, area under the curve (AUC) = 0.755) than unadjusted PSA (OR = 3.31, P = 1.1 × 10−12, AUC = 0.738) in 106 cases and 23,667 controls. Compared to a prostate cancer PGS alone (AUC = 0.712), including genetically adjusted PSA improved detection of aggressive disease (AUC = 0.786, P = 7.2 × 10−4). Our findings highlight the potential utility of incorporating PGS for personalized biomarkers in prostate cancer screening.
Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans
Authors: Geva-Sagiv Maya , Mankin Emily A. , Eliashiv Dawn , Epstein Shdema , Cherry Natalie , Kalender Guldamla , Tchemodanov Natalia , Nir Yuval , Fried Itzhak 
Published: June 2023

AbstractMemory consolidation during sleep is thought to depend on the coordinated interplay between cortical slow waves, thalamocortical sleep spindles and hippocampal ripples, but direct evidence is lacking. Here, we implemented real-time closed-loop deep brain stimulation in human prefrontal cortex during sleep and tested its effects on sleep electrophysiology and on overnight consolidation of declarative memory. Synchronizing the stimulation to the active phases of endogenous slow waves in the medial temporal lobe (MTL) enhanced sleep spindles, boosted locking of brain-wide neural spiking activity to MTL slow waves, and improved coupling between MTL ripples and thalamocortical oscillations. Furthermore, synchronized stimulation enhanced the accuracy of recognition memory. By contrast, identical stimulation without this precise time-locking was not associated with, and sometimes even degraded, these electrophysiological and behavioral effects. Notably, individual changes in memory accuracy were highly correlated with electrophysiological effects. Our results indicate that hippocampo–thalamocortical synchronization during sleep causally supports human memory consolidation.
SciSciNet: A large-scale open data lake for the science of science research
Authors: Lin Zihang , Yin Yian , Liu Lu , Wang Dashun 
Published: June 2023

AbstractThe science of science has attracted growing research interests, partly due to the increasing availability of large-scale datasets capturing the innerworkings of science. These datasets, and the numerous linkages among them, enable researchers to ask a range of fascinating questions about how science works and where innovation occurs. Yet as datasets grow, it becomes increasingly difficult to track available sources and linkages across datasets. Here we present SciSciNet, a large-scale open data lake for the science of science research, covering over 134M scientific publications and millions of external linkages to funding and public uses. We offer detailed documentation of pre-processing steps and analytical choices in constructing the data lake. We further supplement the data lake by computing frequently used measures in the literature, illustrating how researchers may contribute collectively to enriching the data lake. Overall, this data lake serves as an initial but useful resource for the field, by lowering the barrier to entry, reducing duplication of efforts in data processing and measurements, improving the robustness and replicability of empirical claims, and broadening the diversity and representation of ideas in the field.