bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value of cerebrospinal fluid Neutrophil Gelatinase-Associated Lipocalin for differentiation of bacterial meningitis from tuberculous meningitis or cryptococcal meningitis: a prospective cohort study
Authors: Wang Qi , Lin Qingwen , Wang Haiyan , Tang Minjie , Fan Kengna , Zhang Zeqin , Huang Er , Zhang Weiqing , Wang Fengqing , Ou Qishui , liu xiaofeng 
Published: May 2023

Abstract

Background The early differential diagnosis between bacterial meningitis (BM) and tuberculous meningitis (TBM) or cryptococcal meningitis (CM) is still an important clinical challenge. Neutrophil Gelatinase-Associated Lipocalin (NGAL) had been reported as a novel inflammatory biomarker in early stage of infection. This study aimed to explore whether cerebrospinal fluid (CSF) NGAL is a potential biomarker for distinguishing between BM and TBM or CM. Methods Prospectively enrolled the patients with suspected CNS infections at admission and divided them into three case groups: BM (n = 67), TBM (n = 55), CM (n = 51), and an age- and sex-matched hospitalized control (HC, n = 58). Detect the CSF NGAL and evaluate the diagnostic accuracy to distinguish between BM and TBM or CM. Meanwhile, longitudinally measured the CSF NGAL of BM to evaluate whether it would be a monitor of antibacterial treatment. Results The CSF NGAL in BM was significantly higher than in TBM, CM and HC (allP < 0.05), while the serum NGAL was not significantly different among the three case groups. The ROC analysis showed CSF NGAL presented a good diagnostic performance with an AUC of 0.834 (0.770 to 0.886) and at the optimal cutoff value of 74.27 ng/mL with 70.15% sensitivity and 77.36% specificity for discriminating BM with TBM and CM. Meanwhile, the CSF NGAL in the convalescent period of BM was significantly lower than the acute period (P < 0.05). Conclusions CSF NGAL might be a potential biomarker for distinguishing between acute BM and TBM or CM, and it also has some important clinical value for monitoring antibiotic therapy for BM.
Identification and fine mapping of Brmmd1 gene controlling recessive genic male sterility in Brassica rapa L.
Authors: Xiong Xingpeng , Li Xiaoyao , Zhang Shuting , Hu Zhen , Liu Tingting , Qiu Zhengming , Cao Jiashu , Huang Li , Yan Chenghuan 
Published: May 2023

Abstract

Recessive genic male sterility (RGMS) provides an effective approach for the commercial exploitation of heterosis, especially in Brassicacrops. Although some artificial RGMS mutants have been reported in B. rapa, no causal genes derived from these natural mutants have been identified so far. In this study, a spontaneous RGMS mutant Bcajh97-01A derived from the ‘Aijiaohuang’ line traced back to the 1980s was identified. Genetic analysis revealed that the RGMS trait was controlled by a single locus in the Bcajh97-01A/Bsystem. Bulk segregant analysis (BSA) in combination with linkage analysis was employed to delimit the causal gene to an approximate 129 kb interval on chromosome A02. The integrated information of transcriptional levels and the predicted genes in the target region indicated that the Brmmd1 (BraA02g017420) encoding a PHD-containing nuclear protein was the most likely candidate gene. In the RGMS line, a 374 bp miniature inverted-repeat transposable element (MITE) was inserted into the first exon to prematurely stop the Brmmd1 gene translation, thus blocking the normal expression of this gene at the tetrad stage in the Bcajh97-01A. Additionally, a co-segregating structure variation (SV) marker was developed to rapidly screen the RGMS progenies from Bcajh97-01A/B system. Our findings reveal that BraA02g017420 is the causal gene responsible for the RGMS trait. This study lays a foundation for marker-assisted selection and further molecular mechanism exploration of pollen development in B. rapa.
Trajectories of antidepressant use and 6-year change in body weight: a prospective population-based cohort study
Authors: Lassale Camille , Lugon Gabriela , Hernáez Álvaro , Frank Philipp , Marrugat Jaume , Ramos Rafael , Garre-Olmo Josep , Elosua Roberto 
Published: May 2023

Abstract

Background: Antidepressant drug treatment may be associated with weight gain, but long-term studies are lacking.
Methods: We included 3127 adults (1701 women) from the REGICOR study, on average aged 55.6 (SD=11.6) years in 2003-2006, living in North-East of Spain. They had data at two time points (baseline and a median of 6.3 years later) on self-reported antidepressant use, body weight and height, and on baseline smoking, physical activity, diet quality, education, civil status, and depressive symptoms assessed with the Patient Health Questionnaire (PHQ-9) at follow-up. We defined four trajectories of antidepressants use: never use, new use at follow-up, initial use discontinued, persistent use. We used multivariable linear models to estimate the association of these trajectories with the percentage of weight change. In people without obesity at baseline (n=2404), we also estimated the association with obesity incidence at follow-up.
Results: The average 6-year weight gain was 0.53 kg (1.01% body weight), and 24.5% of the participants gained >5% of body weight. The majority (83.6%) of participants did not report any use of antidepressants, 6.2% initiated during follow-up, 5.1% discontinued it, and 5.1% reported their use at both time points. In multivariable analyses, compared to never users, all trajectories were associated with greater weight gain: +1.78% (0.57, 2.98) for initial use discontinued, +2.08% (0.97, 3.19) for new use at follow-up, and +1.98% (95% CI: 0.75, 3.20) for persistent use. In non-obese participants at baseline (n=2404), the odds ratio for becoming obese was 2.06 (1.03, 3.96) for persistent use, and non-statistically significant for the other trajectories.
Conclusions: In a population-based adult cohort, persistent use of antidepressants was strongly associated with weight gain. New and discontinued use was associated with weight gain, but non-significantly to obesity incidence. In light of the obesity pandemic, weight management in the context of antidepressant prescriptions is warranted.
MeViT: Medium-Resolution Vision Transformer for Semantic Segmentation on Landsat Satellite Imagery for Agriculture in Thailand
Authors: Panboonyuen Teerapong , Charoenphon Chaiyut , Satirapod Chalermchon 
Published: May 2023

Abstract
Semantic segmentation is a fundamental task in remote sensing image analysis that aims to classify each pixel in an image into different land use and land cover (LULC) segmentation task. In this paper, We propose MeViT (Medium-Resolution Vision Transformer) on Landsat satellite imagery for the main economic crops in Thailand as follows: (i) para rubber, (ii) corn, and (iii) pineapple. Therefore, our proposed MeViT enhances Vision Transformers (ViTs), one of the modern deep learning on computer vision tasks, to learn semantically rich and spatially-precise multi-scale representations by integrating medium-resolution multi-branch architectures with ViTs. We revised mixed-scale convolutional feedforward networks (MixCFN) by incorporating multiple depth-wise convolution paths to extract multi-scale local information to balance the model’s performance and efficiency. To evaluate the effectiveness of our proposed method, we conduct extensive experiments on the publicly available dataset of Thailand scenes and compare the results with several state-of-the-art deep learning methods such as AutoDeeplab1, SwinTransformer2, Twins3, CSWinTransformer4, SegFormer5, and HRViT6. The experimental results demonstrate that our proposed MeViT outperforms existing methods and performs better in the semantic segmentation of Thailand scenes The evaluation metrics used are precision, recall, F1 score, and mean Intersection over Union (IoU). Among the models compared, MeViT, our proposed model, achieves the best performance in all evaluation metrics. MeViT achieves a precision of 0.9222, a recall of 0.9469, an F1 score of 0.9344, and a mean IoU of 0.8363. These results demonstrate the effectiveness of our proposed approach in accurately segmenting Thai Landsat-8 data. The achieved F1 score of overall using our proposed MeViT is 93.44% that is a major significance of this work.
Development and performance of diagnostic system for small marine Diesel engine functioning in dual fuel system
Authors: Arendt Ryszard , Hupka Jan , Kopczyński Andrzej , Grabowiec Aleksandra 
Published: May 2023

Abstract
The paper presents the PHOTON floating laboratory of Gdansk University of Technology, equipped with a stand for testing a dual fuel (liquid and gaseous) supply system. The influence of the type of fuel on functional effects, emission, and durability of the engine is considered. Engine mooring trials of the unit were carried out to assess the influence of the used fuel on: coolant temperature, lubricating oil temperature, engine housing temperature, and engine vibration in relation to the concentration of nitrogen oxides, carbon oxides, and hydrocarbons in engine exhaust gases for dual engine supply with liquid and gaseous fuel.
Ritual robbery? Disturbation in Early Bronze Age graves in Eastern Poland in the light of microscopic tool marks examinations on the bones
Authors: Hyrchała Anna , Lorkiewicz-Muszyńska Dorota , Sobol Julia , Kurzawska Aldona , Sobkowiak-Tabaka Iwona , Niedźwiedź Józef 
Published: May 2023

Abstract

Analysed graves of the Strzyżów culture, materials obtained and investigated in the last decade, and results of anthropological analysis provided new information on the custom of disturbing burial pits in the Early Bronze Age. It is now possible to suggest and present entirely new conclusions concerning funeral rituals observed by the Strzyżów culture and distinguish five types of disturbed burials from the Early Bronze Age. This paper develops the research of various types of cutmarks disclosed on the bones of the skeleton found in grave no. 13 in Hrubieszów-Podgórze. The authors focused on the application of the morphological characteristics of the bone defects in complex skeletal remains studies, to discuss the possibility of dating occurrence and specifying the tool type. Digital microscopic analysis of different groups of defects (in form of indents, superficial linear grooves, wedge-shaped notches, and gap) was performed. Observed features of the defects of the right fibula and both iliac wings indicate postmortem occurrence, possibly at the same time, using a sharp-edged tool when the bones were ductile, not brittle. Additionally, the localization and characteristics of the tool features imprinted on the fibula and hip bones also indicate the state of skeletonization of the remains at the time the damages occurred. The time interval between death and the occurrence of the revealed bone damage (right fibula and both hip bones) could have been short enough for those still alive to remember the deceased well.
Increased IL-12p70 levels in intraoperative pericardial fluid is predictive of postoperative atrial fibrillation onset after coronary artery bypass surgery
Authors: Liu Yuhua , Xie Enzehua , Yang Yunxiao , Han Zhongyi , Yu Cuntao , Hua Kun , Yang Xiubin 
Published: May 2023

Abstract
Background
Postoperative atrial fibrillation (POAF) is the most frequent complication after heart surgery, prolonging hospital stays, as well as increasing morbidity and death. Previous studies have investigated the determinants of post-heart surgery AF; however, the risk factors contributing to POAF occurrence after coronary artery bypass graft surgery (CABG) remains largely unknown.
Objective
The purpose of this study was to determine if biomarker levels, such as cytokines, within intraoperative pericardial fluid could be used as predictive markers for POAF onset among CABG individuals.
Methods
180 patients with no atrial arrhythmia history, who have undergone CABG, were identified, and the human magnetic Luminex assay was used to measure the levels of 36 pericardial fluid cytokines. POAF development was continuously monitored, using both postoperative electrocardiograms and telemetry strips, until the time of discharge.
Results
POAF was found in 30/124 patients (24.19%). These patients, compared to those with normal sinus rhythms (SR), had significantly higher levels of the interleukin (IL)-12p70 cytokine within their intraoperative pericardial fluids (p < 0.001). Subsequently, IL-12p70 was found to be an independent risk factor for POAF (OR = 1.201; 95% CI, 1.001–1.510; P = 0.014), and ROC analysis determined that the cut-off threshold for predicting POAF onset was 116.435 pg/ml, based on the maximum Youden index (area under the curve: 0.816).
Conclusion
In this study, we demonstrated that increased IL-12p70 levels within intraoperative pericardial fluid was an independent risk factor for POAF, particularly at levels above the cut-off of 116.435pg/ml. This finding thus could serve as a possible marker for detecting future POAF.
Antibiotic prophylaxis during oral implant surgery in Northwest China
Authors: Lin Yao , Yue Jiao , Huang Jing , Cheng Lifei , Pan Wen , Ju Jia , Wei Hongbo , Feng Bin 
Published: May 2023

Abstract
Background
There is still no consensus on prophylactic antibiotics in dental implants in China. This study aims to further understand the current status of prophylactic antibiotics in dental implants in China and to provide evidence-based data for the guidelines of prophylactic antibiotic use in dental implants.
Methods
This study is based on a cross-sectional study of a National dental implant specialist member. The questionnaire survey was conducted from April to December of 2021.It consisted of three parts:the basic information of respondents, the cognitive environment of using prophylactic antibiotics in dental implants in Northwest China, and the use of antibacterial in dental implants.The conclusion was drawn by statistical analysis of the questionnaire survey.
Results
A total of 318 dentists were surveyed. Approximately 65.41% of respondents generally prescribed antibiotics during dental implant surgery, 33.65% just prescribed antibiotics under certain circumstances,and 0.94% never prescribed antibiotics. The most frequently-used antibiotic classes were penicillin (such as amoxicillin), cephalosporin (such as cefazolin), and nitroimidazole (such as metronidazole). It is common to treat patients with a combination of antibiotics. Furthermore, 55.87% of respondents used antibiotics for more than 24 hours in common dental implants, and 85.08% used antibioticsin dental implants with bone grafts.
Conclusions
Since there are no standards for regulations about the choice of varieties, dosage, and course of prescribing antibiotics during dental implants, the use of prophylactic antibiotics is largely based on the experience of dentists. Therefore, it’s necessary to formulate guidelines for using antibiotics in dental implants, improve the standardization of antibiotics, and prevent overuse and bacterial resistance.
Identification and analysis of key miRNA for sex differentiation in hermaphroditic Juglans mandshurica Maxim.
Authors: Li Jingze , Zhang Mengmeng , Wu Jingwen , Qin Baiting , Liu Chunping , Zhang Lijie 
Published: May 2023

Abstract
Background: Juglans mandshurica Maxim. is a monoecious heteromorphic plant. The mechanism of miRNA-mediated sex differentiation and dioecious heterozygosity is unclear.
Results：In this study, 310 known and 278 unknown miRNA were identified and 129 differentially expressed miRNA were screened using high-throughput sequencing technology for microRNA sequencing analysis of male and female flower buds of the protogyny and protandry of Juglans mandshurica. 638 miRNA target genes predicted using PSRobots and these target genes are significantly enriched in reproductive, floral development and phytohormone signaling pathways. Therefore, it is hypothesized that miR159c-3p, miR156d-3p, miR172d, miR171b, miR164a, miR167a, miR319a, miR399a, and miR396t et al. may be the key miRNA affecting sex differentiation in Juglans mandshurica, among which miR164a, miR166c, and miR171c-5p may be the key miRNA for heterosexualism differentiation in Juglans mandshurica. 9 randomly selected miRNAs with significant differences were subjected to real-time fluorescence quantitative PCR to verify the accuracy of high-throughput sequencing. Combined with transcriptome sequencing results for co-analysis, a differential miRNA-differential mRNA primary regulatory network was established.
Conclusion：It was further confirmed that these miRNA play an important role in the sex differentiation of Juglans mandshurica. This study lays the research foundation for the eventual discovery of the molecular mechanism of sex differentiation and heterosexualism in Juglans mandshurica.
Application of ultrasonic bone knife combined with dental electric motor in the extraction of mandibular middle and low impacted teeth
Authors: Wang qian , Zhang T. H. 
Published: May 2023

Abstract
OBJECTIVE: To investigate the clinical application of ultrasonic bone knife (UBK) combined with dental electric motor (DEM) in the extraction of mandibular middle and low impacted teeth.
Methods: From January 2022 to May 2023,200 patients with wisdom teeth were randomly divided into three groups: experimental group A (UBK combined with DEM) and experimental group B (UBK combined with high-speed turbine mobile phone (HSTMP)), control group (bone chisel split crown (BCSC)). The operation time, psychological state during operation, pain, swelling, limitation of mouth opening and other complications on the first, second and third days after operation were recorded.
Results: The operation time of experimental group A(EAG) (12.95 ± 2.12) minutes was shorter than that of experimental group B (EBG) (17.06 ± 2.25) minutes and control group (CG) (23.43 ± 2.18) minutes, the difference was statistically significant (P < 0.05). The psychological state of EAG was significantly lower than that of EBG and CG (P < 0.05). The postoperative pain, swelling, limitation of mouth opening and complications in the EAG were significantly lower than those in the EBG and CG (P < 0.05).
CONCLUSION: UBK combined with DEM in the extraction of mandibular middle and low obstructed teeth has good results, good prognosis, high safety, short operation time, better psychological status of patients, low postoperative pain, swelling, mouth opening restriction and complication rate, and is currently the preferred extraction method.
Speed approach for genetic analysis of quantitative traits in linseed (Linum usitatissimum L.) genotypes under sub temperate conditions of Western Himalayas using shuttle breeding
Authors: S Ranjeet Singh , Paul Satish 
Published: May 2023

Abstract
Gene action studies are important component to formalize the breeding programmes. In the present study, genetic components of variation for different traits were determined in one and half year using triple test cross approach along with shuttle breeding in linseed. Epistasis was observed significant for all studied traits. The [i] type epistasis was significant for days to 50%ﬂowering, days to 75% maturity, secondary branches per plant, capsules per plant, 1000-seed weight and aerial biomass per plant. [j +1] type epistatic interactions were significant for all the traits except seed yield per plant. The additive (D) and dominance (H) component were significant for all the studied traits. This illustrated that both additive and dominance gene actions controlling all the traits but in higher order as epistasis is also present. The average degree of dominance indicated the preponderance of additive type of gene action for aerial biomass per plant, primary branches per plant, seed yield per plant, secondary branches per plant, capsules per plant, days to 50% flowering, harvest index, seeds per capsule, days to 75% maturity and technical height,whereas non-additive type of gene action was preponderant for plant height and 1000-seed weight. The additive gene effects were predominant as compared to dominance effects for almost all of the traits along with seed yield per plant. Under such genetic control in the expression of traits, early generation selection might be beneficial for the improvement of these traits. However, where both additive and dominance gene actions prevail, genetic disassortative mating followed by recurrent selection methodmight be suitable approach towards the genetic improvement of the traits.
Material requirements planning system considering batch size and minimum order quantity for items of suppliers
Authors: Javadi Seyed Mahdi , Sadjadi Seyed Jafar , Makui Ahmad 
Published: May 2023

Abstract
Material requirements planning (MRP) is an intelligent information system and a decision maker that determines the type of raw materials, the amount of them, and their supplying time in order to realize production schedule of products and work-in-process items in a manufacturing system. The inputs of MRP model include bill of materials, master production schedule, lead times, and inventory of the items. The main output of the model is material supplying schedule, and MRP sub-outputs include purchase advice, control report for the consumed items, financial planning, budgeting, and so on.
If in each manufacturing system we split production costs into three kinds of raw material costs, salary costs, and overhead costs, in the real environment, 60-90 percent of total costs are related to raw material costs. Therefore, in each manufacturing system, it is necessary to consider an appropriate inventory control system to control the costs of inventory system and provide right inventory, with right amount, at the right time, at the right price, and with appropriate quality.
In this research, two constraints on the size of the packaging of goods and the minimum order amount that a supplier provides for a product are added to the model. By closing the existing gap, the mentioned model can be operationally implemented and provide appropriate decision-making outputs. Therefore, at first, we will review the introduction and previous researches that have been done in this field. Then, we will describe the components of the material requirements planning model. In the following, the above-mentioned two constraints are added to the model and the material requirements planning system is presented.
Chlorophyllin as a Photosensitizer in Photodynamic Antimicrobial Materials
Authors: Jiang Chenyu , Scholle Frank , Jin Fangyu , Wei Qufu , Wang Qingqing , Ghiladi Reza A. 
Published: May 2023

Abstract
Self-disinfecting materials that are both safe and scalable for production are increasingly in demand, particularly in healthcare settings where they can be used to combat hospital-acquired infections (HAIs). Here, we employed the natural food colorant chlorophyllin (E140ii) as a photosensitizer to prepare photodynamic antimicrobial materials through both chemical conjugation and electrospinning, resulting in chlorophyllin-grafted cotton fabric (Chl-fabric) and chlorophyllin-embedded polyacrylonitrile nanofibers (Chl-NF), respectively. The materials were characterized by a number of physical methods, as was their ability to generate singlet oxygen upon visible light illumination. The best results with Chl-fabric yielded 99.998% inactivation of vancomycin-resistant E. faecium and 99.994% of methicillin-resistant S. aureus after 60 min visible light illumination (400–700 nm, 80 ± 5 mW/cm2), whereas Chl-NF inactivated both bacteria by 99.9999%. Feline calicivirus was also photodynamically susceptible, with 99.8% inactivation by both materials. Gram-negative Klebsiella pneumoniae was not initially susceptible to photodynamic inactivation by Chl-NF, however addition of the photothermal agent MoS2 fully inactivated (99.9999%) this pathogen under NIR illumination, indicative of synergistic photothermal and photodynamic activities. These findings suggest that chlorophyllin can be used in photodynamic antimicrobial materials against drug-resistant Gram-positive bacteria, and that its efficacy can be synergistically amplified in the presence of a photothermal agent against Gram-negative pathogens.