bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitophagy in metabolic syndrome
Authors: Miao Mei‐Qi , Han Yu‐Bo , Liu Li 
Published: April 2023

AbstractMetabolic syndrome (MS), a chronic and non‐communicable pathological condition, is characterized by a constellation of clinical manifestations including insulin resistance, abdominal adiposity, elevated blood pressure, and perturbations in lipid metabolism. The prevalence of MS has increased dramatically in both developed and developing countries and has now become a truly global problem. Excessive energy intake and concomitant obesity are the main drivers of this syndrome. Mitophagy, in which cells degrade damaged mitochondria through a selective form of autophagy, assumes a crucial position in the regulation of mitochondrial integrity and maintenance. Abnormal mitochondrial quality could result in a spectrum of pathological conditions related to metabolic dysfunction, including metabolic syndrome, cardiovascular ailments, and neoplasms. Recently, there has been a proliferation of research pertaining to the process of mitophagy in the context of MS, and there are various regulatory pathways in MS, including pathways like the ubiquitin‐dependent mechanism and receptor‐mediated mechanisms, among others. Furthermore, studies have uncovered that the process of mitophagy serves a defensive function in the advancement of Metabolic Syndrome, and inhibition of mitophagy exacerbates the advancement of MS. As a result, the regulation of mitophagy holds great promise as a therapeutic approach in the management of Metabolic Syndrome. In this comprehensive analysis, the authors present a synthesis of the diverse regulatory pathways involved in mitophagy in the context of Metabolic Syndrome, as well as its modes of action in metabolic disorders implicated in the development of MS, Including obesity, insulin resistance (IR), and type 2 diabetes mellitus (T2DM), offering novel avenues for the prophylaxis and therapeutic management of MS.
Autologous blood transfusion promotes autophagy and inhibits hepatocellular carcinoma progression through HIF‐1α signalling pathway
Authors: Bai Yu , Liu Tong , Cui Ying‐Hui , Li Zhen‐Zhou , Zhou Xiao‐Fang , Cheng Yong , Wang Jin‐Huo , Guo Jian‐Rong 
Published: April 2023

AbstractTo explore the molecular mechanism of autologous blood transfusion promoting autophagy of hepatocellular carcinoma (HCC) cells and inhibiting the HCC progression through HIF‐1α signalling pathway. This is a research paper. Rat hepatocellular carcinoma model and HepG2 cell model were built. The rats with HCC were conducted a surgery, and their blood was collected for detection to detect the recurrence and metastasis of the rats. Western blot was used to analysed the expression of HIF‐1α, TP53, MDM2, ATG5 and ATG14 protein. The apoptosis rate of HepG2 cells was detected by flow cytometry, and autophagosomes were observed by transmission electron microscopy. HIF‐1α expression was measured by immunofluorescence assay. The expressions of HIF‐1α, TP53, MDM2, ATG5 and ATG14 protein were highest in model + autoblood group compared with the model group. HIF‐1α content of model group was higher, but content of TP53, MDM2, ATG5 and ATG14 in the model group is the second. The highest apoptosis rate was found in HepG2 + autoblood group. The number of autophagosomes in HepG2 + autoblood was obviously larger than that of HepG2 + autoblood + inhibitor. HIF‐1α expression of immunofluorescence assay showed that high expression of HIF‐1α was clearly observed in HepG2 and HepG2 + autoblood group from confocal observation. However, there was no HIF‐1α protein expression in HepG2 + autoblood + inhibitor group. The migration rate in HepG2 group, HepG2 + autoblood group and HepG2 + autoblood + inhibitor group was 85.71 ± 7.38%, 14.36 ± 6.54% and 61.25 ± 5.39%, respectively. Autologous blood transfusion promotes autophagy of HCC cells through HIF‐1α signalling pathway, which further inhibits HCC migration and erosion.
Effect of different finishing and polishing procedures on surface roughness and microbial adhesion on highly‐filled composites for injectable mold technique
Authors: Vulović Stefan , Stašić Jovana N. , Ilić Jugoslav , Todorović Miloš , Jevremović Danimir , Milić‐Lemić Aleksandra 
Published: April 2023

AbstractObjectiveTo evaluate the effect of different finishing and polishing procedures on surface roughness and microbial adhesion and viability of Streptococcus mutans on novel highly‐filled composites for injectable mold technique.Materials and MethodsOne hundred sixty specimens were divided into four material groups: FSF (Filtek Supreme Flowable Restorative), TE (Tetric EvoFlow), GUI (G‐aenial Universal Injectable) and GUF (G‐aenial Universal Flo). Within each group, specimens were split regarding finishing and polishing (F/P) procedures into: SLD (Sof‐Lex Discs), SLS (Sof‐Lex Spirals), OG (OneGloss) and PG (PoGo). Surface roughness was analyzed using profilometer (Ra and Rz) and scanning electron microscopy (SEM) and Strep. mutans biofilm formation was analyzed using colony forming unit (CFU) and cell viability assay. Two‐way analysis of variance (ANOVA) followed by Tukey's post hoc test were used for comparison among groups, Pearson's coefficient was applied for the correlation between Ra and CFU/ml and all data were presented as mean ± SD.ResultsBoth materials and F/P procedures affect Ra, Rz and Strep. mutans CFU/ml values (p ≤ 0.05). Considering the Ra and Rz, GUI and GUF revealed lower values, compared to FSF and TE and SLD and SLS revealed lower values, compared to OG and PG. Considering the Strep. mutans CFU/ml and viability, GUI and TE presented lower values, compared to GUF and FSF and SLD and SLS presented lower values, compared to OG and PG. Moderate positive correlation was found between Ra and CFU/ml (r = 0.552).ConclusionsThe smoothest surfaces possess GUI and GUF, among materials and SLD and SLS, among F/P procedures. GUI adhered the lowest amount of Strep. mutans, due to the smoothest surfaces. FSF and GUF revealed the highest amount of Strep. mutans, due to bis‐GMA, bis‐MEPP and TEGDMA in their composition.Clinical SignificanceThe findings of the present study may be beneficial for the proper selection of highly‐filled composites and an adequate finishing and polishing procedure when performing the injectable mold composite resin veneer technique.
Construction and analysis of the forced vibration model of separating screen under a dropped potato
Authors: Shang Zhenyu , Wang Fang , Xie Shengshi , Deng Weigang , Li Junru , Guo Yaping , Lu Kailiang , Gai Xiuzhi , Ji Xinjie 
Published: April 2023

AbstractTo determine the damage characteristics of potato falling on the separating screen and their relationship with the vibration characteristics, it is expected to provide a reference for the structural optimization of potato harvesting related machinery. The vibration characteristics of the separating screen were theoretically analyzed and a forced vibration model of separating screen was developed. The effects of vibration model parameters on the damage volume of potatoes were studied by single‐factor experiments with fall height, potato mass, fall direction, and potato varieties as experimental factors. Especially, the changes of decay coefficient α and the potato damage volume with test factors were obtained: the attenuation coefficient α increased with increasing falling height and potato mass and showed a significant correlation with potato damage volume. The decay coefficient α becomes largest when the potato falls along the length direction and smallest when it falls along the thickness direction. The α decreased with increasing hardness of potato varieties and showed a significant negative correlation with potato damage volume. Fitting equations between the attenuation coefficient α and the damage volume for each effects were established to predict the potato damage under different height, mass, and variety, as follows: V1 = 498035α − 2516, V2 = 209646α − 286, and V3 = −84397α + 1149.Practical ApplicationsDuring the mechanized harvest process, severe potato damage occurred on the swing separation screen. This will seriously affect the quality and economic value of potatoes. At present, there are few studies on the vibration damage theory and experiment during potato harvest. Therefore, in order to clarify the vibration characteristics of the separation screen and its relationship with the potato damage characteristics, we studied the influence of the vibration characteristics on the potato damage through the drop test, and established the vibration model of the separation screen. The relationship between the model parameters and the potato damage volume was further explored, and a mathematical model was developed to predict the volume of potato damage. This study provides a reference for the study of the coupled vibration of the potato soil mixture and the optimization of the potato soil separation device.
The relationship between Meckel's cartilage resorption and incisor tooth germ in mice
Authors: Shimazu Yoshihito , Taya Yuji , Soeno Yuuichi , Kudo Tomoo , Sato Kaori , Takeda Mamoru 
Published: April 2023

AbstractOur understanding of the initiation and cellular mechanisms underlying endochondral resorption of Meckel's cartilage (MC) remains limited. Several studies have shown that the resorption site of MC and the mandibular incisor tooth germ are located close to each other. However, whether incisor tooth germ development is involved in MC resorption remains unclear. In this study, we aimed to elucidate the spatio‐temporal interaction between the initiation site of MC resorption and the development of incisor tooth germs in an embryonic mouse model. To this effect, we developed a histology‐based three‐dimensional (3D) reconstruction technique using paraffin‐embedded serial sections of various tissues in the jaw. The serial sections were cut in the frontal section and the tissue constituents (e.g., MC, incisor, and mineralized mandible) were studied using conventional and enzyme‐based histochemistry. The outline of each component was marked on the frontal sectional images and 3D structures were constructed. To assess the vascular architecture at the site of MC resorption, immunohistochemical staining using anti‐laminin, anti‐factor VIII, and anti‐VEGF antibodies was performed. MC resorption was first observed on the lateral incisor‐facing side of the cartilage rods at sites anterior to the mental foramen on E16.0. The 3D analysis suggested that: (a) the posterior region of the clastic cartilage resorption corresponds to the cervical loop of the incisor; (b) the cervical portion of the tooth germ inflates probably due to temporal cellular congestion prior to differentiation into matrix‐producing cells; (c) the incisor tooth germ tissue is present in close proximity to MC even in mouse with continuously growing tooth and determines the disappearance of MC as the tooth development.
Respiratory device‐related pressure injuries in hospitalised adults: An integrative review
Authors: Fidalgo De Faria Maíla , Bontempo De Azevedo Lorena , Faria De Oliveira Karoline , Guimarães Raponi Maria Beatriz , Da Silva Alves Filgueira Viviane , Marques Dos Santos Felix Márcia , Sagrario Gómez Cantarino Maria , Barbosa Maria Helena 
Published: April 2023

AbstractObjectiveTo identify the main ventilatory support medical devices related to the occurrence of pressure injuries in hospitalised adults, as well as the most frequent anatomical localisations of these injuries.MethodsThe Integrative review was registered at Open Science Framework as per DOI 10.17605/OSF.IO/P3NTZ. Two independent reviewers, in May 2022, searched the databases: PubMed, Embase, Cochrane Database of Systematic Reviews, LILACS and CINAHL; no language or publication year restriction. The review question was: What are the ventilatory support medical devices that cause PIs in hospitalised adults more often? The terms for searching the database were: “adult,” “noninvasive ventilation,” “artificial respiration.” and “pressure injury,” and their synonyms. This review followed the PRISMA checklist.ResultsThe final sample was 21 articles. Oxygen nasal catheters caused up to 40.7% of the pressure injuries by ventilatory support devices identified, all in the ears. Noninvasive mechanical ventilation oronasal masks presented an incidence of pressure injuries of 63.3%. The nasal bridge was the site most affected by this mask. The Set of Holders for Insight® endotracheal tubes was the device that caused the most pressure injuries, with an incidence of 75%, affecting lip commissure. Tracheostomy cannula accounted for 18.2% of the pressure injuries related to ventilatory support devices; all lesions were in the neck.ConclusionThe ventilatory support devices causing pressure injuries and the most affected sites were, respectively, nasal catheters, ears; masks, nasal bridge; endotracheal tubes, lip commissures; tracheostomy cannulas, neck.Relevance for clinical practiceKnowing which respiratory devices cause pressure injuries more often in hospitalised adults and which anatomical localisations are more likely to be affected is fundamental for adopting preventive measures and reducing the occurrence of this problem.No patient or public contributionNo patient or public contribution because of the review.
Residual pulmonary infiltrates, symptoms and diffusion impairment at 1‐year after severe COVID‐19 infection have different associated factors
Authors: Menéndez Rosario , Méndez Raúl , Latorre Ana , González‐Jiménez Paula , Peces‐Barba Germán , Molina María , España Pedro Pablo , García Estela , Consuegra‐Vanegas Angélica , Pando‐Sandoval Ana , Panadero Carolina , Figueira‐Gonçalves Juan Marco , De la Rosa David , Sibila Oriol , Martínez‐Pitarch María Dolores , Toledo Nuria , Cejudo Pilar , Almonte‐Batista Wanda , Macías‐Paredes Abigail , Badenes Diana , Pérez‐Rodas Eli Nancy , Lázaro Javier , Quirós Sarai , Cordovilla Rosa , Cano‐Pumarega Irene , Torres Antoni ,   RECOVID
Published: April 2023

AbstractIntroductionAfter severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1‐year follow‐up. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (DLCO) at 1‐year follow‐up in patients from the Spanish Registry RECOVID.MethodsRECOVID collected symptom and radiological and functional lung tests data on hospitalized patients with coronavirus disease 2019 during the acute phase and at the 6‐ and 12‐month follow‐up visits.ResultsOf the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow‐up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae and 31% had reduced DLCO. Independently associated factors included female sex, asthma and the requirement for invasive or non‐invasive mechanical ventilation. Complete radiological resolution was 72.2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO2/FiO2 <450 or CURB‐65 ≥2. Reduced DLCO was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO2/FiO2 <450 and CURB‐65 ≥2 and the requirement of respiratory support.At 12 months, a proportion of the asymptomatic patients showed reduced DLCO (9.5%), radiological findings (25%) or both (11%).ConclusionsThe factors associated with symptom persistence, incomplete radiological resolution and DLCO <80% differed according to age, sex, comorbidities and respiratory support. The burden of symptoms, reduced DLCO and incomplete radiological resolution were considerable in patients with SARS‐CoV‐2 pneumonia at the 1‐year follow‐up after hospitalisation.
Testing R&D‐Based Endogenous Growth Models*
Authors: Kruse‐Andersen Peter K. 
Published: April 2023

AbstractThis study examines US productivity growth through the lens of R&D‐based growth models. A general R&D‐based model, nesting different model varieties, is developed. These varieties are tested using a novel cointegrating relationship and US data for the period 1953–2018. The results provide evidence against the widely used fully endogenous variety and support for other varieties including the semi‐endogenous variety. Further, the results are systematically consistent with the presence of fishing‐out effects in knowledge production, implying that productivity‐enhancing innovations become increasingly harder to achieve as technologies become more advanced. Forecasts suggest that the US productivity growth slowdown continues over the coming decades.
Successful Repair of M. obliquus Internus Abdominis Avulsion at the Iliac Crest—Operative Technique in Professional Soccer Players
Authors: Lohrer Heinz , Höferlin Andreas 
Published: April 2023

ObjectiveSports related injuries to the anterolateral abdominal wall have been described as side strain injuries or hip pointer. So far, only a few cases of avulsion injuries of the m. obliquus internus abdominis muscle from the iliac crest have been described. All were treated conservatively. The aim of this study is to present the surgical technique.MethodsThis report presents three cases of professional soccer players who were treated surgically with transosseous reattachment to the iliac crest. These male players were 23, 25, and 29 years old. Two of them suffered a direct contusion and one an indirect injury. The diagnosis was suspected based on the patient's history and clinical examination and confirmed by MRI. In each case, the fibrocartilaginous layer of the m. obliquus internus was separated 2 cm from the iliac crest. All three players were operated by aponeurotic m. obliquus internus refixation to the lateral iliac crest (three transosseous drill holes). Return to play was 55, 60, and 122 days postoperatively. Functional limitations, symptoms, sports/recreational activities, and quality of life in terms of occupational, social, emotional, and lifestyle concerns were measured using the iHOT 12 instrument at 11.1 and 9.7 years postoperatively.ResultsSix weeks postoperatively, sport‐specific training was started. After 2 to 4 months, all three patients were fully reintegrated into their elite sports and unrestricted sports ability was achieved. Long‐term follow‐up was performed using the German version of the iHOT‐12 questionnaire and 92.7% and 99.9% were calculated for the two German speaking soccer players.ConclusionsOur cases demonstrate that transosseous suture reattachment was a successful procedure that allowed a safe and predictable return to sport. Full performance and excellent, long lasting treatment results were achieved.
Mpox in the United States: Current implications for public health nursing
Authors: Blackwell Christopher W. , Hicks Rodney W. , Castillo Humberto López , Guido‐Sanz Francisco , Anderson Mindi 
Published: April 2023

AbstractIn 2022, mpox, an orthopoxvirus first isolated in 1958 in cynomolgus monkeys, became a global public health threat. While the virus can be communicated through skin‐to‐skin contact from any infected person to non‐infected person, most cases in the United States have been in gay and bisexual men. Consequently, early public health and community‐based efforts concentrated on reducing infections in this population. This article explores current mpox case count epidemiologic data and trends. In addition, vaccination indications, contraindications, adverse events, and national administration data are provided along with directions for nurses and other clinicians moving forward in the outbreak.
Assessment of nucleus accumbens impairment in a rat model of postoperative cognitive dysfunction using diffusion tensor imaging
Authors: Guo Xin‐Gui , Kang Li‐Qing , Wang Ning , Wang Jie‐Xia 
Published: April 2023

BackgroundPostoperative cognitive dysfunction (POCD) often occurs in elderly patients, causing depression and other symptoms. Nucleus accumbens (NAc) is involved in depression. We investigate the diffusion tensor imaging (DTI) parameters of NAc in a POCD model of depression.MethodsTwenty‐month‐old male Sprague–Dawley (SD) rats were randomly divided into the POCD and Sham groups. The POCD group underwent exploratory laparotomy to establish a POCD depression model, while the Sham group underwent a sham operation. The fractional anisotropy (FA) and mean diffusivity (MD) values of the bilateral NAc, behavioural changes of forced swimming test and sucrose preference rate, and pathological changes of glial fibrillary acidic protein (GFAP) fluorescent intensity were observed at 15 days (D15) and 30 days (D30) after the operation.ResultsThe FA value of the bilateral NAc area in the POCD group was lower than that in the Sham group at the two time periods after the operation (P < 0.05). However, the MD value at D30 was higher in the POCD group than in the Sham group (P < 0.05). The FA value in the POCD group was lower at D30 than at D15 (P < 0.05). The floating time was prolonged while the sucrose preference rate was decreased in the POCD group compared with the Sham group (P < 0.05). The floating time in the POCD group was longer at D30 than at D15. However, the sucrose preference rate in the POCD was lower at D30 than at D15. The GFAP fluorescent intensity in the bilateral NAc region in the POCD group was higher than in the Sham group (P < 0.05).ConclusionMicrostructural changes of the NAc area are associated with POCD related depression. In addition, FA and MD were demonstrated to be effective in diagnosing and monitoring postoperative depression and its severity.
Follow the hand that feeds you? The effects of non‐governmental cash transfers on citizenship
Authors: Grisolia Filippo , Dewachter Sara , Holvoet Nathalie 
Published: April 2023

AbstractCash transfers (CT) are increasingly used as fundamental components of countries' poverty reduction and social protection strategies. Yet not much is known about how these interventions shape beneficiaries' relations with the state and citizenship in general, and even less evidence is available on how CTs distributed by non‐state actors affect the aforementioned variables. This paper analyses how a non‐governmental universal unconditional mobile CT (a small‐scale universal basic income experiment), handed out by a foreign NGO in a rural Ugandan village, influenced citizenship. The article zooms in on effects on recipients' perceptions of the state and interactions with government representatives, where both could potentially yield repercussions on the broader social contract. The study implements matching techniques and social network analysis to explore how the transfer influenced citizenship over time. Results suggest that the CT generated a positive effect on the non‐state actor's legitimacy, without necessarily causing a lasting impact on the legitimacy of the state. Major impacts were recorded in the treatment village's ‘call‐to‐action’ network, highlighting patterns of change in beneficiaries' relations with local duty bearers, such as the crowding out of (multiple) local leaders by an external actor linked to the CT project. These findings confirm the possibility of inducing unintended effects in local communities through CT initiatives implemented by non‐state actors.