bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebroprotective effect of sitagliptin and aminoguanidine combination in disorders of cerebral circulation
Authors: Kurkin D. V. , Bakulin D. A. , Morkovin E. I. , Gorbunova Yu. V. , Strygin A. V. , Andriashvili T. M. , Sokolova A. A. , Bolokhov N. S. , Pustynnikov V. E. , Fomichev E. A. , Baskova A. V. , Polodyants S. S. , Kasparova A. V. 
Published: August 2023

The aim of the study was to evaluate a cerebroprotective activity of the sitagliptin and aminoguanidine combination in rats with an acute and chronic cerebral circulation insufficiency, as well as with a traumatic brain injury.Materials and methods. The study was carried out on male Wistar rats in 3 stages using, respectively, a model of a chronic pathology: a chronic cerebral circulation insufficiency (CCCI), as well as 2 models of the acute brain injury (BI): an acute cerebral circulation insufficiency (ACCI), and a traumatic brain injury (TBI). А CCCI was modeled by a bilateral stenosis of the common carotid arteries (by 50%), a model of a hemorrhagic stroke caused by an intracerebral injection of the autologous blood was used as a stroke, a TBI was modeled by a mechanical damage to the brain tissue. To assess the pathology course severity, the following tests were used: Adhesion test, Open field, Morris water maze test, as well as Garcia and Combs&D’Alecy scales. In the animals with an acute damage to the brain at the end of the experiment, the severity of edema of the affected hemisphere was also determined. The treatment was with sitagliptin (10 mg/kg), aminoguanidine (25 mg/kg), or a combination thereof. The obtained data were subjected to the statistical processing.Results. In the course of the study, it was found out that the administration of a sitagliptin and aminoguanidine combination, unlike each of the components, had a cerebroprotective effect in the animals with a chronic or acute damage to the brain, reducing the severity of psychoneurological (cognitive and sensory-motor) disorders, as well as the brain edema.Conclusion. Aminoguanidine, as an iNOS blocker, enhances the action of sitagliptin, preventing the brain edema development and reducing the neurological deficit severity (the severity of cognitive and sensory-motor impairments) in the animals with an acute and chronic cerebral circulation insufficiency.
Development of composition and technology for obtaining antimicrobial composition based on mono- and sesquiterpenoids
Authors: Lakomkina E. V. , Atazhanova G. A. , Akhmetova S. B. , Zilfikarov I. N. 
Published: August 2023

The article reflects the results of the essential oils selection for the compositions with antibacterial and antifungal properties. The technology of their production is represented.The aim of the work was the development of technology and the study structure of new essential oils compositions with antibacterial and antifungal activities.Material and methods. The following plants have been used in the work: the herb of Hyssopus ambiguus (Trautv.) Iljin, the herb of Thymus crebrifolius Klokov, the herb of Thymus marschallianus Willd, the herb of Thymus serpyllum L., and the essential oils obtained from them. The composition of the essential oils was determined by Gas Chromatography Mass Spectrometry. The main physical and chemical parameters of the compositions were evaluated in accordance with the requirements of the Russian State Pharmacopoeia, the XIVth edition. The tests for the antimicrobial activity were carried out using the strains of Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Candida albicans ATCC 10231.Results. Compositions with an activity against microorganisms Staphylococcus aureus, Bacillus subtilis, Escherichia coli and fungi Candida albicans have been obtained and studied. The composition based on essential oils of Hyssopus ambiguus (Trautv.) Iljin and Thymus marschallianus Willd. contained 139 components, the main ones of which are eucalyptol (6.51%) and terpinen-4-ol (1.95%). The composition of essential oils of Hyssopus ambiguus (Trautv. Iljin) and Thymus crebrifolius Klokov contained 137 components (eucalyptol (20.37%), terpinen-4-ol (7.03%), Ʈ-muurol (2.28%), γ-terpinene (2.23%), β-myrcene (2.09%), etc.). The composition of the essential oils of Hyssopus ambiguus (Trautv.) Iljin and Thymus serpyllum L. contained 149 components (the main ones are eucalyptol (7.33%) and α-terpineol (0.9%)).Conclusion. The technology has been proposed and the structure of the essential oils compositions with antibacterial and antifungal activities has been established.
“Off-label” drugs: legal problems and socio-economic aspects of application practice
Authors: Russkikh S. V. , Tarasenko E. A. , Moskvicheva L. I. , Orlov S. A. , Tryakin A. A. , Vorobeva A. V. , Beneslavskaya O. A. , Makarova V. I. , Putilina E. A. , Utkin S. A. 
Published: August 2023

The aim of the work was to analyze Russian and foreign experience in the regulation and application practice of “off-label” drugs in order to develop recommendations on the optimization of their application in clinical practice.Material and methods. The analysis of scientific articles and legal documents of the Russian Federation and foreign countries published from 2011 to 2022 on the websites Consultant Plus, FDA, EMA, NCBI, e-library, as well as a qualitative sociological study conducted in May-August 2022 ‒ 11 in-depth interviews with experts in the field of the healthcare system of the Russian Federation.Results. The social and economic aspects have been considered and the list of legal problems in the application practice of “off-label” drugs has been disclosed. A state analysis of the regulatory and legal framework on the drugs application practice by healthcare professionals in the absence of registered indications for “off-label” drugs use has been presented. The use of an unregistered medicinal product in the territory of the Russian Federation in everyday medical practice has been considered. The analysis of the Russian and foreign experience in regulating the use of drugs in the absence of their registration in the country, as well as the absence of registration of some indications for their prescription in the instructions for the medical use of such drugs has been also carried out. The authors have formulated the key problems of the use of “off-label” drugs in clinical practice. Based on the results of the in-depth interviews, the recommendations of the expert community on the ways to optimize the use of “off-label” drugs have been identified and concretized.Conclusion. The results of this study made it possible to formulate recommendations for expanding the ability of specialists to prescribe “off-label” drugs treatment while maintaining a proper degree of the state control over this process: a legislative consolidation of the regional health authorities’ obligations and responsibilities on the drug provision; creating an open and transparent system for the “off-label” drugs use by patients and their legal representatives, the mandatory full information of the patient about the fact of using the “off-label” drug, as well as the risk and nature of the development of possible adverse reactions. When prescribing these drugs, the patient safety should be the top priority.
Comparison of the modified Blumgart mattress vs. interrupted suture pancreaticojejunostomy in minimally invasive pancreaticoduodenectomy
Authors: Choi Sung Hoon , Kuchta Kristine , Paterakos Pierce , Rojas Aram , Mehdi Syed Abbas , Talamonti Mark S. , Hogg Melissa E. 
Published: August 2023

Aim: The modified Blumgart mattress (BM) and conventional interrupted suture (IS) methods are currently the most widely adopted pancreaticojejunostomy (PJ) techniques utilized during minimally invasive pancreaticoduodenectomy (MIPD). This study aimed to evaluate the postoperative outcomes between the two PJ techniques using robotic and laparoscopic approaches.
Methods: This was a retrospective study involving patients who underwent robotic or laparoscopic pancreaticoduodenectomy (PD) performed by two surgeons from two institutions. Surgical outcomes of the patients were compared according to the PJ techniques of robotic BM (Rob-BM), robotic IS (Rob-IS), and laparoscopic IS (Lap-IS), which were further analyzed among patients who had a soft pancreas and small pancreatic duct, while those with pancreatic ductal adenocarcinoma were excluded from the study.
Results: A total of 230 patients underwent MIPD with 63 Rob-BM, 48 Rob-IS, and 119 Lap-IS for PJ. Within the study population, clinically relevant-postoperative pancreatic fistula (CR-POPF) rates were comparable between Rob-BM and Rob-IS (6.3% vs. 10.4%, P = 0.283) and between Rob-IS and Lap-IS (10.4% vs. 7.6%, P = 0.661). Comparing patients with soft pancreas and small pancreatic duct, CR-POPF rates were not statistically different among the groups [16.0% (Rob-BM) vs. 10.5% (Rob-IS), P = 0.055, and 10.5% (Rob-IS) vs. 10.1% (Lap-IS), P = 0.543]. In the multivariable analysis for risk factors of POPF, soft pancreatic textures and periampullary pathology other than pancreatic cancer were found to be risk factors.
Conclusion: POPF rates after MIPD were not different according to the PJ methods of BM and IS when performed by skilled surgeons.
Analisis Deskriptif terhadap Profit Perusahaan X Periode 2012 – 2021 dengan Bantuan Software R Studio
Authors: Afrinda Aulia Nisa , Abdullah Ahmad Dzikrullah  
Published: August 2023

Tulisan ini memuat analisis deskriptif mengenai profit perusahaan X di Jakarta Selatan menggunakan software R Studio. Profit perusahaan X merupakan laba atau keuntungan yang diperoleh oleh perusahaan X dari hasil pengerjaan proyek permintaan klien. Analisis deskriptif pada penelitian ini merupakan analisis statistika deskriptif secara kuantitatif berupa nilai profit perusahaan X selama 10 tahun, yaitu periode 2012 – 2021 dalam satuan rupiah. Langkah pertama yang dilakukan dalam penulisan laporan ini ialah melakukan kegiatan kerja praktik selama satu bulan di perusahaan X, Jakarta Selatan untuk mendapatkan data yang diinginkan. Langkah kedua yaitu mendeskripsikan data yang didapatkan dengan melakukan uji asumsi normalitas terlebih dahulu, kemudian memulai analisis deskriptif terhadap data profit perusahaan X selama 10 tahun terakhir. Dari analisis deskriptif kuantitatif yang dilakukan menggunakan bantuan sioftware R Studio didapatkan nilai minimum, maximum, mean, median, sum, range, standar deviasi dan koefisien variansi dari data profit perusahaan X. Terakhir, didapatkan pengetahuan mengenai kondisi profit perusahaan X selama 10 tahun terakhir.
Analisis Pengaruh Sektor Pariwisata Terhadap Tingkat Pengangguran Terbuka di Kabupaten/ Kota Daerah Istimewa Yogyakarta
Authors: Benny Banu Adjie  , Atina Ahdika  
Published: August 2023

Penelitian ini dilakukan untuk mengetahui apakah terdapat pengaruh Jumlah Hotel bintang dan non bintang, Jumlah Rumah Makan yang sudah dibina, Jumlah Wisatawan Nusantara dan Mancanegara terhadap Tingkat Pengangguran Terbuka (TPT) di Kabupaten/Kota Provinsi Daerah istimewa Yogyakarta tahun 2016 – 2020. Metode yang digunakan pada penelitian ini adalah metode regresi data panel dengan pengolahan data nya menggunakan software RStudio dan Excel. Data panel merupakan gabungan data time series dengan cross section, setelah dilakukan beberapa beberapa uji, diperoleh model terbaik adalah Random Effect Model (REM) dengan pengaruh cross section. Selain itu diperoleh juga koefesien determinasi (R2) untuk random effect model yaitu sebesar 69.06%. Nilai tersebut menunjukan bahwa kemampuan variable independent dalam menjelaskan variable dependen sebesar 69.06% sedangkan sisanya 30.94% dijelaskan variabel lain yang tidak termasuk model. Dari hasil yang didapatkan, diperoleh kesimpulan bahwa jumlah hotel, Jumlah Restoran dan jumlah wisatawan memiliki pengaruh terhadap tingkat pengangguran terbuka di Kabupaten/Kota Provinsi DIY, dengan hasil uji overall sebesar 1.4327x10-11, lalu dari hasil uji t-statistik diperoleh hasil bahwa variable Jumlah Hotel memiliki pengaruh yang cukup baik dan positif terhadap TPT di Kabupaten/Kota di DIY, sedangkan variable Jumlah wisatawan memiliki pengaruh dan negative terhadap pengangguran terbuka di Provinsi DIY.
Hubungan Tingkat Pendidikan dengan Partisipasi Masyarakat pada Bank Sampah di Wilayah Kecamatan Kemayoran
Authors: Amalia Dinianti  
Published: August 2023

This study is aims to find out the relationship between The Level of Education towards Public Participation at Waste Bank in The Subdistrict Area of Kemayoran. This study was quantitative research. The population were 134 participants of the waste bank in The Subdistrict Area of Kemayoran. The sample was 100 participants. The research sampling techniques were Slovin and Proportional Stratified Sampling. Proportional Stratified Sampling was according to the level of education of people who participated on waste bank. Data collection technique was done by using a questionnaire. The data analysis technique was done by multiple linear analysis. The result shows that there is a significant relationship between The Level of Education towards Public Participation at Waste Bank in The Subdistrict Area of Kemayoran, the result is 0,315 and the determinant coefficient (r2) is 0,099 or 9,9% in percentage. The result means that the level of education only contributes 9,9% as the factor of Public Participation at Waste Bank in The Subdistrict Area of Kemayoran. There are four more factors such as knowledge and skill, gender, types of occupation, and belief of the certain culture which can contribute another 90,1% to Public Participation at Waste Bank in The Subdistrict Area of Kemayoran. This study can be used as the reference for the next study that relates to social and environmental science.
Keywords: Level of Education, Public Participation
Peran Komunitas Pramuwisata Baduy Luar Dalam Mempertahankan Kearifan Lokal
Authors: Firdaus Muhammad Nova , Budiaman  , Nova Scorviana Herminasari  
Published: August 2023

Abstract
This study aims at obtaining data on the role of the community of Baduy Luar guides in an effort to maintain local wisdom along with socio-cultural changes that occur in the Baduy Luar village, Kanekes Village, Lebak Regency, Banten. The researcher uses a qualitative approach. Data collection techniques are carried out by semi-structured interviews, observations, analysis of documents and field notes. The results of the study concluded that the tourism services carried out by the HPI-DPU Baduy were still very simple in general but were in accordance with the concept of tourism services, starting from transfers, guiding tours, and transfer out. The concept of service they are doing is directly related to their strategy in maintaining local wisdom. Their role is at least in the three dimensions of local wisdom, namely: (1) local values; (2) local resources; and (3) local group solidarity. The socio-cultural changes that occur in the Baduy Luar community in the tour community are caused by several factors. Internally, changes occur because of Baduy’s people attitude who are increasingly open. Then externally, changes occur because the Baduy people interact more intensively with outside communities such as meeting tourists, trading, participating in training and farming outside their area.
Keywords: guide community, Baduy community, local wisdom
PERILAKU KONFORMITAS SOSIAL REMAJA TERHADAP MUSIK K-POP SEBAGAI BENTUK IDENTITAS SOSIAL UNIT KEGIATAN MAHASISWA HALLYU UP! EDUTAINMENT BANDUNG
Authors: Listia Maulida Putri  , Budiaman  , Saipiatuddin  
Published: August 2023

Abstract
This research aims to determine (1) know the social conformity behavior of Hallyu Up! Edutainment Bandung on the growth of K-Pop music culture (2) find out the youth of Hallyu Up! Edutainment Student Activity Unit makes K-Pop music a form of social identity. The research methodology used is a qualitative approach with data techniques used are interviews, literature study, and observation. The method in data analysis used is data reduction, data presentation, and drawing conclusions. The results of this study indicate (1) social conformity behavior by teenagers. Hallyu Up! Edutainment Student Activity Unit is cohesiveness, agreement and obedience in a group to the development of K-Pop music, (2) cause of teenagers Hallyu Up! Edutainment Student Activity Unit makes K-Pop music a form of social identity in society, is (a) internal factors, including motivational factors, in-group attractiveness, interests and talents, and agreement in achieving the same goal, (b) external factors, including the influence of friendship groups and social media. Keywords: Social Conformity, Social Identity and K-Pop Music

Abstrak
Penelitian ini bertujuan untuk mengetahui (1) mengetahui perilaku konformitas sosial remaja Unit Kegiatan Mahasiswa Hallyu Up! Edutainment terhadap perkembangan budaya musik K-Pop (2) mengetahui remaja Unit Kegiatan Mahasiswa Hallyu Up! Edutainment menjadikan musik K-Pop sebagai bentuk identitas sosial. Metodologi penelitian yang digunakan adalah pendekatan kualitatif dengan teknik pengumpulan data yang digunakan adalah kegiatan wawancara, studi pustaka, dan observasi. Metode dalam analisis data yang digunakan adalah reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan (1) perilaku konformitas sosial yang dilakukan remaja Unit Kegiatan Mahasiswa Hallyu Up! Edutainment yaitu kekompakan, kesepakatan dan ketaatan dalam sebuah kelompok terhadap perkembangan musik K-Pop, (2) penyebab remaja Unit Kegiatan Mahasiswa Hallyu Up! Edutainment menjadikan musik K-Pop sebagai bentuk identitas sosialnya di masyarakat, yaitu (a) faktor internal, diantaranya faktor motivasi, daya tarik in-group, minat dan bakat, dan kesepakatan dalam mencapai tujuan yang sama, (b) faktor eksternal, diantaranya pengaruh keompok pertemanan dan media sosial.
Kata Kunci: Konformitas Sosial, Identitas Sosial, dan Musik K-Pop
Perbedaan Efektivitas Model Pembelajaran Social Action Berbasis Creative Pedagogy dan Project Based Learning untuk Meningkatkan Kompetensi Kewirausahaan
Authors: Widiastuti Anik , Supriatna Nana , Disman Disman , Nurbayani Siti 
Published: August 2023

Entrepreneurial competence is one of the important competencies to master as one of the keys to preparing a generation that is ready to face the challenges of the 21st century. The importance of entrepreneurial competence has not been fully realized to be integrated into learning and has not been matched by the use of learning models that lead to strengthening entrepreneurial competence in students. This study aims to determine the differences in the effectiveness of Social Action models based on Creative Pedagogy and Project Based Learning to increase entrepreneurial competence. This research is an experimental research pre test-post test control group design. The research respondents were SMP 1 Pakem Sleman DIY students with a total of 32 students in class A as the experimental class and 32 students in class D as the control class who were selected by purposive sampling technique. Data collection techniques using tests, questionnaires, and observation sheets. The results of the study show that the Social Action model based on Creative Pedagogy is more effective in increasing social-creativepreneurship competencies.
Keywords: learning model, social action, creative pedagogy, project based learning, entrepreneurial competence, social studies
HUBUNGAN ANTARA KOMUNIKASI INTERPERSONAL GURU DAN MINAT BELAJAR DENGAN PRESTASI BELAJAR IPS SISWA DI SMP NEGERI 74 JAKARTA
Authors: Purwandari Dian Alifia , Riani Hanifah 
Published: August 2023

HUBUNGAN ANTARA KOMUNIKASI INTERPERSONAL GURU DAN MINAT BELAJAR DENGAN PRESTASI BELAJAR IPS SSISWA DI SMP NEGERI 74 JAKARTA
Oleh: Hanifah Riani dan Hanifah Riani
Abstrak
Penelitian ini bertujuan untuk memperoleh pengetahuan berdasarkan bukti data empiris atau fakta yang sesungguhnya (valid), benar dan dapat dipercaya (reliabel) tentang adanya hubungan komunikasi interpersonal guru dengan prestasi belajar IPS, hubungan minat belajar dengan prestasi belajar IPS, hubungan komunikasi interpersonal guru dan minat belajar secara bersama-sama terhadap prestasi belajar IPS. Metode penelitian yang digunakan adalah metode kuantitatif dengan desain analisis korelasional. Teknik pengambilan sampel yang dilakukan adalah secara acak sederhana dengan adanya proporsional tingkatan.
Berdasarkan analisis data dapat disimpulkan bahwa: 1) Hasil pengujian Signifikan antara Komunikasi Interpersonal Guru dengan Prestasi Belajar IPS ditunjukan pada koefisien korelasi Pearson product moment sebesar 0,754 sedangkan thitung sebesar 5,74> ttabel (1,67). Adapun regresi bersifat linier dengan model persamaan Y= 0,569+0,206X1. 2) Hasil pengujian hipotesis kedua diperoleh kesimpulan bahwa ada hubungan yang signifikan antara minat belajar dengan prestasi belajar IPS ditunjukan pada koefisien korelasi sebesar 0,668 sedangkan thitung sebesar 3,23 > ttabel (1,67). Adapun regresi bersifat linier dengan model persamaan Y =0,654+0,120X2. 3)secara bersama- sama ada hubungan yang signifikan antara variabel komunikasi interpersonal guru (X1) dan minat belajar (X2) dengan prestasi belajar IPS (Y) dengan koefisien korelasi sebesar 0,791. Hasil pengujian hipotesis ketiga diperoleh kesimpulan bahwa 0,362. Hubungan regresi ganda bersifat linier dengan model persamaan Y =0,654+0,151X1 + 0,056 X2. Kontribusi determinasi dari masing-masing bvariabel bebas terhadap variabel terikat adalah: Variabel komunikasi interpersonal guru sebesar 56,7%. Variabel minat belajar sebesar 44,6%. Kontribusi determinasi kedua variabel bebas secara bersama-sama terhadap variabel terikat adalah 62,5 %. Berdasarkan hasil tersebut disimpulkan bahwa prestasi belajar IPS disebabkan oleh dua faktor secara bersamaan yaitu komunikasi interpersonal guru dan minat belajar sebesar 62,5% dan sisanya 37,5% faktor-faktor lainnya yang tidak diteliti dalam penelitian ini.

Kata Kunci: Komunikasi Interpersonal, Minat Belajar, Prestasi Belajar IPS
A Novel Reconstruction Technique for Chronic Distal Biceps Tendon Rupture
Authors: Moriya Koji , Maki Yutaka , Koda Hisao , Tsubokawa Naoto 
Published: August 2023

Case:
A 71-year-old otherwise healthy man presented with an 8-week history of elbow pain and weakness in both elbow flexion and forearm supination. Magnetic resonance imaging revealed complete rupture of the distal biceps tendon insertion associated with 65 mm of proximal retraction. At 10 weeks after initial injury, the patient underwent a novel reconstruction technique using a periosteal flap from the iliac crest; subsequently, all symptoms resolved.

Conclusion:
Chronic distal biceps tendon injuries can be reconstructed safely and effectively using a periosteal flap from the iliac crest that allows not only rigid but also biological graft attachment.