bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting Small and Medium Industries: The Korean Experience
Authors: Yun Yeo-Gyeong 
Published: June 2023

The promotion of small and medium-scale industries is politically an attractive policy for achieving social equity and justice and economically desirable for attaining balanced growth. However, in practice, the promotion of these industries is an extremely difficult task, and usually the policies are costly for the government without producing the desired results. The reason is that it is generally difficult for governments to find a common denominator for establishing and executing policies for promoting small and medium industries because of their large numbers and diversity in their nature of business. There is, therefore, no simple or universal policy strategy. In general, there are two kinds of promotional policies for the development of small and medium industries. One is to create as many industries as possible and help them to survive, and the other is to create and/or help small-scale industries to grow and become medium-scale industries through import substitution for the domestic market and eventually export promotion for the international market. In the case of the Republic of Korea, the government adopted the second approach for promoting small and medium industries.
Block codes on pomset metric
Authors: Shriwastva Atul Kumar , Selvaraj R. S. 
Published: June 2023

Given a regular multiset [Formula: see text] on [Formula: see text], a partial order [Formula: see text] on [Formula: see text], and a label map [Formula: see text] defined by [Formula: see text] with [Formula: see text], we define a pomset block metric [Formula: see text] on the direct sum [Formula: see text] of [Formula: see text] based on the pomset [Formula: see text]. The pomset block metric extends the classical pomset metric introduced by Sudha and Selvaraj and generalizes the poset block metric introduced by Alves et al. over [Formula: see text]. The space [Formula: see text] is called the pomset block space and we determine the complete weight distribution of it. Further, [Formula: see text]-perfect pomset block codes for ideals with partial and full counts are described. Then, for block codes with chain pomset, the packing radius and Singleton bound are established. The relation between maximum distance separable (MDS) codes and [Formula: see text]-perfect codes for any ideal [Formula: see text] is investigated. Moreover, the duality theorem for an MDS pomset block code is established when all the blocks have the same size.
Rapid glacial sedimentation and overpressure in oozes causing large craters on the mid-Norwegian margin: integrated interpretation of the Naust, Kai and Brygge formations
Authors: Bellwald Benjamin , Manton Ben , Lebedeva-Ivanova Nina , Zastrozhnov Dmitry , Myklebust Reidun , Planke Sverre , Forsberg Carl Fredrik , Vanneste Maarten , Locat Jacques 
Published: June 2023

Abstract

Along continental margins with rapid sedimentation, overpressure may build up in porous and compressible sediments. Large-scale release of such overpressure has major implications for fluid migration and slope stability. Here, we study if the widespread crater-mound-shaped structures in the subsurface along the mid-Norwegian continental margin are caused by overpressure that accumulated within high-compressibility oozes sealed by low-permeability glacial muds. We interpret 56 000 km
2
of 3D and 150 000 km
2
of 2D-cubed seismic data in the Norwegian Sea, combining horizon picking, well ties and seismic geomorphological analyses of the crater-mound landforms. Along the mid-Norwegian margin, the base of the glacially influenced sediments abruptly deepens to form 28 craters with typical depths of
c.
100 m, areal extents of up to 5130 km
2
and volumes of up to 820 km
3
. Mounds are observed in the vicinity of the craters at several stratigraphic levels above the craters. We present a new model for the formation of the craters and mounds where the mounds consist of remobilized oozes evacuated from the craters. In our model, repeated and overpressure-driven sediment failure is interpreted to cause the crater-mound structures, as opposed to erosive megaslides. Seismic geomorphological analyses suggest that ooze remobilization occurred as an abrupt energetic and extrusive process. The results also suggest that rapidly deposited, low-permeability and low-porosity glacial sediments seal overpressure that originated from fluids being expelled from the underlying high-permeability and high-compressibility biosiliceous oozes.
Memory Disaggregation: Advances and Open Challenges
Authors: Al Maruf Hasan , Chowdhury Mosharaf 
Published: June 2023

Compute and memory are tightly coupled within each server in traditional datacenters. Large-scale datacenter operators have identified this coupling as a root cause behind fleetwide resource underutilization and increasing Total Cost of Ownership (TCO). With the advent of ultra-fast networks and cache-coherent interfaces, memory disaggregation has emerged as a potential solution, whereby applications can leverage available memory even outside server boundaries.
This paper summarizes the growing research landscape of memory disaggregation from a software perspective and introduces the challenges toward making it practical under current and future hardware trends. We also reflect on our seven-year journey in the SymbioticLab to build a comprehensive disaggregated memory system over ultra-fast networks. We conclude with some open challenges toward building next-generation memory disaggregation systems leveraging emerging cache-coherent interconnects.
Reservoir Sensitivity Analysis of Tight Sandstone and Its Controlling Factors: A Case Study from Chang 4+5 to Chang 6 Reservoirs in N 212 Well Block of Nanniwan Oilfield, Ordos Basin
Authors: Fan Pingtian , Liu Yuetian , Li Ping , Guo Yanqin , Yu Weichu , Li Baiqiang 
Published: June 2023

Reservoir sensitivity can lead to the physical or chemical reactions to block the pore throat. It is helpful for reducing the damage on tight sandstone reservoir to study the reservoir sensitivity and its controlling factors. This paper mainly focuses on the tight sandstone of the Chang 4+5 and Chang 6 reservoirs of the Yanchang Formation in the Nanniwan Oilfield, Ordos Basin. The reservoir sensitivity characteristics were evaluated through the core sensitivity experiment after the petrological and petrophysical analysis and pore structure study. The influencing factors on tight sandstone reservoir sensitivity were discussed from several aspects, such as clay mineral composition, porosity, permeability, and pore structure. The results show that the rock type of the Chang 4+5 and Chang 6 reservoirs in the N 212 well block of the Nanniwan Oilfield is mainly arkose, with the mean porosity of 11.2% and 8.45% and the mean permeability of

0.35
×

10

−
3

μm2 and

0.44
×

10

−
3

μm2, respectively. The clay mineral components mainly include chlorite and illite/smectite. Both the two reservoirs are characterized by moderate to weak velocity sensitivity, moderate to weak water sensitivity, moderate to strong salt sensitivity, weak acid sensitivity, and moderate to weak alkali sensitivity. In specific, the Chang 4+5 reservoir is stronger in velocity and salt sensitivities, while it is weaker in water, acid, and alkali sensitivities than those of the Chang 6. The major controlling factors on reservoir sensitivity are clay mineral component, petrophysical property, and pore structure. Among these, the velocity sensitivity displays the positive correlation with pore structure, porosity, and permeability. The water sensitivity will become strong with the increase of the volume content of illite/smectite, but weak with the getting better of pore structure. The acid sensitivity is positively correlated with the volume content of chlorite but is negatively correlated with pore structure. With the getting better of pore structure, the salt sensitivity and alkali sensitivity will become strong and weak, respectively. The research results can be as the guidance for the tight sandstone reservoir protection in the study area and the adjustment and optimization of the regional reservoir development scheme.
CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer
Authors: Fattori Stéphane , Le Roy Aude , Houacine Jemila , Robert Lucie , Abes Riad , Gorvel Laurent , Granjeaud Samuel , Rouvière Marie-Sarah , Ben Amara Amira , Boucherit Nicolas , Tarpin Carole , Pakradouni Jihane , Charafe-Jauffret Emmanuelle , Houvenaeghel Gilles , Lambaudie Eric , Bertucci François , Rochigneux Philippe , Gonçalves Anthony , Foussat Arnaud , Chrétien Anne-Sophie , Olive Daniel 
Published: June 2023

AbstractRegulatory T cells (Treg) impede effective antitumor immunity. However, the role of Tregs in the clinical outcomes of patients with triple-negative breast cancer (TNBC) remains controversial. Here, we found that an immunosuppressive TNBC microenvironment is marked by an imbalance between effector αβCD8+ T cells and Tregs harboring hallmarks of highly suppressive effector Tregs (eTreg). Intratumoral eTregs strongly expressed PD-1 and persisted in patients with TNBC resistant to PD-1 blockade. Importantly, CD25 was the most selective surface marker of eTregs in primary TNBC and metastases compared with other candidate targets for eTreg depletion currently being evaluated in trials for patients with advanced TNBC. In a syngeneic TNBC model, the use of Fc-optimized, IL2 sparing, anti-CD25 antibodies synergized with PD-1 blockade to promote systemic antitumor immunity and durable tumor growth control by increasing effector αβCD8+ T-cell/Treg ratios in tumors and in the periphery. Together, this study provides the rationale for the clinical translation of anti-CD25 therapy to improve PD-1 blockade responses in patients with TNBC.Significance:An imbalance between effector CD8+ T cells and CD25high effector Tregs marks immunosuppressive microenvironments in αPD-1–resistant TNBC and can be reversed through effector Treg depletion to increase αPD-1 efficacy.
Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma
Authors: Gulay Kevin Christian Montecillo , Zhang Xinlian , Pantazopoulou Vasiliki , Patel Jay , Esparza Edgar , Pran Babu Deepa Sheik , Ogawa Satoshi , Weitz Jonathan , Ng Isabella , Mose Evangeline S. , Pu Minya , Engle Dannielle D. , Lowy Andrew M. , Tiriac Hervé 
Published: June 2023

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a low survival rate. Recently, new drugs that target KRASG12D, a common mutation in PDAC, have been developed. We studied one of these compounds, MRTX1133, and found it was specific and effective at low nanomolar concentrations in patient-derived organoid models and cell lines harboring KRASG12D mutations. Treatment with MRTX1133 upregulated the expression and phosphorylation of EGFR and HER2, indicating that inhibition of ERBB signaling may potentiate MRTX1133 antitumor activity. Indeed, the irreversible pan-ERBB inhibitor, afatinib, potently synergized with MRTX1133 in vitro, and cancer cells with acquired resistance to MRTX1133 in vitro remained sensitive to this combination therapy. Finally, the combination of MRTX1133 and afatinib led to tumor regression and longer survival in orthotopic PDAC mouse models. These results suggest that dual inhibition of ERBB and KRAS signaling may be synergistic and circumvent the rapid development of acquired resistance in patients with KRAS mutant pancreatic cancer.

Significance:
KRAS-mutant pancreatic cancer models, including KRAS inhibitor–resistant models, show exquisite sensitivity to combined pan-ERBB and KRAS targeting, which provides the rationale for testing this drug combination in clinical trials.
Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial
Authors: Ellingsen Espen B. , O'Day Steven , Mezheyeuski Artur , Gromadka Agnieszka , Clancy Trevor , Kristedja Timothy S. , Milhem Mohammed , Zakharia Yousef 
Published: June 2023

Abstract

Purpose:
Cancer vaccines represent a novel treatment modality with a complementary mode of action addressing a crucial bottleneck for checkpoint inhibitor (CPI) efficacy. CPIs are expected to release brakes in T-cell responses elicited by vaccination, leading to more robust immune responses. Increased antitumor T-cell responses may confer increased antitumor activity in patients with less immunogenic tumors, a subgroup expected to achieve reduced benefit from CPIs alone. In this trial, a telomerase-based vaccine was combined with pembrolizumab to assess the safety and clinical activity in patients with melanoma.

Patients and Methods:
Thirty treatment-naïve patients with advanced melanoma were enrolled. Patients received intradermal injections of UV1 with adjuvant GM-CSF at two dose levels, and pembrolizumab according to the label. Blood samples were assessed for vaccine-induced T-cell responses, and tumor tissues were collected for translational analyses. The primary endpoint was safety, with secondary objectives including progression-free survival (PFS), overall survival (OS), and objective response rate (ORR).

Results:
The combination was considered safe and well-tolerated. Grade 3 adverse events were observed in 20% of patients, with no grade 4 or 5 adverse events reported. Vaccination-related adverse events were mostly mild injection site reactions. The median PFS was 18.9 months, and the 1- and 2-year OS rates were 86.7% and 73.3%, respectively. The ORR was 56.7%, with 33.3% achieving complete responses. Vaccine-induced immune responses were observed in evaluable patients, and inflammatory changes were detected in posttreatment biopsies.

Conclusions:
Encouraging safety and preliminary efficacy were observed. Randomized phase II trials are currently ongoing.
AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells
Authors: Sakemura R. Leo , Hefazi Mehrdad , Cox Michelle J. , Siegler Elizabeth L. , Sinha Sutapa , Hansen Michael J. , Stewart Carli M. , Feigin Jennifer M. , Manriquez Roman Claudia , Schick Kendall J. , Can Ismail , Tapper Erin E. , Horvei Paulina , Adada Mohamad M. , Bezerra Evandro D. , Kankeu Fonkoua Lionel Aurelien , Ruff Michael W. , Forsman Cynthia L. , Nevala Wendy K. , Boysen Justin C. , Tschumper Renee C. , Grand Cory L. , Kuchimanchi Kameswara R. , Mouritsen Lars , Foulks Jason M. , Warner Steven L. , Call Timothy G. , Parikh Sameer A. , Ding Wei , Kay Neil E. , Kenderian Saad S. 
Published: June 2023

Abstract
The receptor tyrosine kinase AXL is a member of the TYRO3, AXL, and proto-oncogene tyrosine-protein kinase MER family and plays pleiotropic roles in cancer progression. AXL is expressed in immunosuppressive cells, which contributes to decreased efficacy of immunotherapy. Therefore, we hypothesized that AXL inhibition could serve as a strategy to overcome resistance to chimeric antigen receptor T (CAR T)–cell therapy. To test this, we determined the impact of AXL inhibition on CD19-targeted CAR T (CART19)–cell functions. Our results demonstrate that T cells and CAR T cells express high levels of AXL. Specifically, higher levels of AXL on activated Th2 CAR T cells and M2-polarized macrophages were observed. AXL inhibition with small molecules or via genetic disruption in T cells demonstrated selective inhibition of Th2 CAR T cells, reduction of Th2 cytokines, reversal of CAR T-cell inhibition, and promotion of CAR T-cell effector functions. AXL inhibition is a novel strategy to enhance CAR T-cell functions through two independent, but complementary, mechanisms: targeting Th2 cells and reversing myeloid-induced CAR T-cell inhibition through selective targeting of M2-polarized macrophages.
Host Interactions with Engineered T-cell Micropharmacies
Authors: Bourne Christopher M. , Wallisch Patrick , Dacek Megan M. , Gardner Thomas J. , Pierre Stephanie , Vogt Kristen , Corless Broderick C. , Bah Mamadou A. , Romero-Pichardo Jesus E. , Charles Angel , Kurtz Keifer G. , Tan Derek S. , Scheinberg David A. 
Published: June 2023

Abstract
Genetically engineered, cytotoxic, adoptively transferred T cells localize to antigen-positive cancer cells inside patients, but tumor heterogeneity and multiple immune escape mechanisms have prevented the eradication of most solid tumor types. More effective, multifunctional engineered T cells are in development to overcome the barriers to the treatment of solid tumors, but the interactions of these highly modified cells with the host are poorly understood. We previously engineered prodrug-activating enzymatic functions into chimeric antigen receptor (CAR) T cells, endowing them with a killing mechanism orthogonal to conventional T-cell cytotoxicity. These drug-delivering cells, termed Synthetic Enzyme-Armed KillER (SEAKER) cells, demonstrated efficacy in mouse lymphoma xenograft models. However, the interactions of an immunocompromised xenograft with such complex engineered T cells are distinct from those in an immunocompetent host, precluding an understanding of how these physiologic processes may affect the therapy. Herein, we expanded the repertoire of SEAKER cells to target solid-tumor melanomas in syngeneic mouse models using specific targeting with T-cell receptor (TCR)–engineered T cells. We demonstrate that SEAKER cells localized specifically to tumors, and activated bioactive prodrugs, despite host immune responses. We additionally show that TCR-engineered SEAKER cells were efficacious in immunocompetent hosts, demonstrating that the SEAKER platform is applicable to many adoptive cell therapies.
Supplementary Figure 2 from Metronomic administration of topotecan alone and in combination with docetaxel inhibits epithelial-mesenchymal transition in aggressive variant prostate cancers
Authors: MITRA GHOSH TARASWI , Mazumder Suman , Davis Joshua , YADAV JYOTI , AKINPELU AYUBA , ALNAIM AHMED , KUMAR HARISH , WALIAGHA RAZAN , Church Bird Allison E , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , MISHRA AMARJIT , Yates Clayton C. , MITRA AMIT K , Arnold Robert D 
Published: June 2023

<p>Supplementary Fig. 2 shows Ingenuity pathway analysis (IPA) predictions for European American/ Caucasian American (EA/CA) ARHigh/mCSPC (LNCaP, VCAP, 22RV1), ARLow/mCRPC/NEPC (PC-3, PC-3M, DU145) and African American (AA) ARHigh/mCSPC (MDA-Pca-2b) PCa cell lines as well as normal prostate cell lines RWPE1 and RWPE2.

IPA predicted A) Diseases and biological pathways for development of ARLow/mCRPC/NEPC. Major pathways are cell movement, morbidity, mortality, migration, invasion, survival, viability and development of vasculature- vasculogenesis and angiogenesis. B) Causal network pathway for development of ARLow/mCRPC/NEPC, which include oxidative phosphorylation, p70S6K, unfolded response, TREM1 signaling, NF-kB signaling, ERK5 signaling, IL-8 signaling, BAG2 signaling, Integrin signaling and VEGF signaling. C) IPA predicted HIF1α and EMT as key pathways associated with PCa development in African Americans (AA).</p>
Infarct Core Growth During Interhospital Transfer For Thrombectomy Is Faster At Night
Authors: Seners Pierre , Mlynash Michael , Sreekrishnan Anirudh , Ter Schiphorst Adrien , Arquizan Caroline , Costalat Vincent , Henon Hilde , Bretzner Martin , Heit Jeremy J. , Olivot Jean-Marc , Lansberg Maarten G. , Albers Gregory W. , Schmitt Perrine , Sablot Denis , Lalu Thibault , Bricout Nicolas , Albucher Jean-François , Cognard Christophe , Cordonnier Charlotte , Christensen Soren , Scheldeman Lauranne 
Published: June 2023

BACKGROUND:
Preclinical stroke models have recently reported faster infarct growth (IG) when ischemia was induced during daytime. Considering the inverse rest-activity cycles of rodents and humans, faster IG during the nighttime has been hypothesized in humans.

METHODS:
We retrospectively evaluated acute ischemic stroke patients with a large vessel occlusion transferred from a primary to 1 of 3 French comprehensive stroke center, with magnetic resonance imaging obtained at both centers before thrombectomy. Interhospital IG rate was calculated as the difference in infarct volumes on the 2 diffusion-weighted imaging, divided by the time elapsed between the 2 magnetic resonance imaging. IG rate was compared between patients transferred during daytime (7:00–22:59) and nighttime (23:00–06:59) in multivariable analysis adjusting for occlusion site, National Institutes of Health Stroke Scale score, infarct topography, and collateral status.

RESULTS:

Out of the 329 patients screened, 225 patients were included. Interhospital transfer occurred during nighttime in 31 (14%) patients and daytime in 194 (86%). Median interhospital IG was faster when occurring at night (4.3 mL/h; interquartile range, 1.2–9.5) as compared to the day (1.4 mL/h; interquartile range, 0.4–3.5;
P
<0.001). In multivariable analysis, nighttime transfer remained independently associated with IG rate (
P
<0.05).

CONCLUSIONS:
Interhospital IG appeared faster in patients transferred at night. This has potential implications for the design of neuroprotection trials and acute stroke workflow.
Merchants of Light and Lamps: John Evelyn’s Transition from Descriptive to Experimental Natural History
Authors: Matei Oana 
Published: June 2023

Abstract
This paper discusses the methodological relation between natural history and natural philosophy in the case of John Evelyn (1620–1706). I propose to examine Evelyn’s tree cultivation projects and to identify relevant aspects of his attempt to move from descriptive natural history to experimental natural history. My central argument is that Evelyn’s intention in this endeavour was to develop a series of experimental natural history projects that could provide general laws and axioms of nature as foundations for natural philosophy. I suggest that, considering Bacon’s methodological recommendations regarding the relation between natural history and natural philosophy, Evelyn evolved from one “Baconian” role to another. While in the 1650s Evelyn acted as a “merchant of light,” as he devoted his interest to writing natural history projects based on collecting data and commonplacing different sources, in the 1660s he moved to an advanced role, that of a “compiler” or a “lamp,” in which he composed projects of experimental natural history. In Evelyn’s view, the latter kind of natural history would serve as a methodological step in building a natural philosophy.
Thomas Aquinas on the Metaphysical Structure of Artifacts
Authors: Skrzypek Jeremy W. 
Published: June 2023

Abstract
It is now standard to interpret Aquinas as recognizing two main types of material objects: substances and artifacts, where substances are those material objects that result from some particular substantial form inhering in prime matter, and artifacts are those material objects that result from some particular accidental form inhering in one or more material substances. There are two problems with this standard interpretation. First, there are passages in which Aquinas states that accidental forms should be understood not as inhering in substances from the outside, but as entering into their composition so as to be included among their metaphysical parts. Second, there are passages in which Aquinas states that it is impossible for any accidental form to be shared by two or more substances. This article considers what implications these two observations might have for how we understand the metaphysical structure of artifacts in Aquinas’s ontology.