bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic-free Helicobacter pylori eradication – case reports and review of the literature
Authors: Bahadori Babak , Tonninger-Bahadori Katayoun , Nekrep Karl 
Published: January 2023

Abstract
Background: Standard Helicobacter pylori eradication therapy is based on proton pump inhibitors and antibiotics. There are, however, important limitations: increasing antibiotic resistance of Helicobacter pylori, medical contraindications, and an increasing unwillingness among patients to use antibiotics.
Case presentations: We present three exemplary case reports of successful antibiotic-free Helicobacter pylorieradication therapies, one for each of these limiting categories: a 61-year-old female Caucasian patient refractory to prior eradication therapy, an 80-year-old female Caucasian patient with contraindication to antibiotics, and a 41-year-old male Caucasian patient refusing antibiotics. A review of the literature attempts to provide a scientific rationale for proton pump inhibitor-based and probiotics-supported Helicobacter pylorieradication.
Conclusion: Antibiotics-free Helicobacter pylorieradication may offer a therapeutic option for patients in whom classical eradication therapy cannot be conducted or who are refractory to antibiotics. Clinical trials are needed to scientifically evaluate the concept presented here.
First Realization of Quantum Energy Teleportation on Quantum Hardware
Authors: Ikeda Kazuki 
Published: January 2023

Abstract
Teleporting physical quantities to remote locations is a remaining key challenge for quantum information science and technology. Quantum teleportation has enabled the transfer of quantum information, but teleportation of quantum physical quantities has not yet been realized. Here we report the first realization and observation of quantum energy teleportation on real quantum hardware. We achieve this by using several IBM’s superconducting quantum computers. The results are consistent with the exact solution of the theory and are improved by the mitigation of measurement error. Quantum energy teleportation requires only local operations and classical communication. Therefore our results provide a realistic benchmark that is fully achievable with current quantum computing and communication technologies.
Serum free light chains benefit diagnosis of multiple myeloma in orthopaedic patients with normal serum total proteins, creatinine, calcium and hemoglobin
Authors: Jia Zhongwei , Xia Jinxing , Lu Qiong 
Published: January 2023

Abstract
Background:

A substantial number of MM patients with bone destruction are initially admitted into Orthopedics due to bone pain. However, routine laboratory tests usually fail to identify these patients and delay optimal therapy. Therefore, there is a clear medical need in early diagnose MM on these patient population.

Methods

Ninety-four orthopaedic patients were enrolled from July 2019 to December 2021. Of them, 42 patients were diagnosed as MM during postoperative pathology, but exhibited normal serum total proteins, creatinine, calcium and hemoglobin before operation. The rest 52 orthopaedic patients were pathologically excluded from MM and recruited into control group. The immunofixation electrophoresis (IFE) assays were performed to detect sFLC levels of all the subjects for comprehensively analyzed.

Results

The sFLC κ/λ ratios in 37 out of 42 MM patients were outside the reference range (0.31 ~ 1.56). All 42 MM patients were divided into two groups based on sFLC, κ/λ ratio > 1 or κ/λ < 1 respectively. And there were no significant differences in levels of serum total proteins, creatinine, calcium and hemoglobin between these two groups and control group.

Conclusions

This study highlighted the clinical significance of sFLC detection in early diagnosis of MM in orthopedics patients with unexplained bone destruction, supporting appropriate treatment choices preoperatively.
The Comparison of Partial Hemivertebrae Resection versus Total Hemivertebrae Resection by posterior only approach with short-segment fixation in children with Congenital Scoliosis. A minimum of a 4-year follow-up study
Authors: Guo Chaofeng , Zhang HongQi , Alonge Emmanuel , Wang Yuxiang , Ang Deng , Liu ShaoHua 
Published: January 2023

Abstract
The series of complications involved in hemivertebra resection has not yet led to a precise solution. Therefore, we aim to compare less invasive, partial hemivertebra resection versus total hemivertebra resection for this anomaly in children with a long-term follow-up. From 2011 to 2016, we did a retrospective study on 31 patients with congenital scoliosis associated with hemivertebrae who had a posterior-only approach comprising 16 patients with total hemivertebrae resection (TR), 15 patients with partial hemivertebrae resection (PR), and short-segment fusion. There was 31 congenital scoliosis associated with hemivertebrae patients in both the PR and TR groups, and the average mean age at the time of surgery was 6.3 ± 2.0 and 6.0 ± 1.9, respectively. The PR group had an equipotential correction rate of cobb angle at post-operation (4.3 ± 4.9 and 2.2 ± 3.2, P = 0.174) and the last follow-up (8.3 ± 5.4 and 5.5 ± 2.4, P = 0.087) as the TR group. Partial hemivertebra resection is efficient and secure. A less invasive technique obtained an equivalent well-maintained correction rate to the total hemivertebra resection with a better quality of life outcome of the patients.
A Parallel Feature Selection Method Based on NMI-XGBoost and Distance Correlation for Typhoon Trajectory Prediction
Authors: Qiao Baiyou , Hao Yuanqing , Wang Rui , Wang Peirui , Han Donghong , Wu Gang 
Published: January 2023

Abstract

Typhoon trajectory related data involves many factors such as atmospheric factors, oceanic factors, and physical factors. It has the characteristics of high dimension, strong spatio-temporal correlation, and non-linear correlation, which increases the difficulty of typhoon trajectory prediction. Using feature selection approaches to select appropriate prediction factors becomes an important means to reduce the dimension of typhoon trajectory related data and improve the performance and accuracy of typhoon trajectory prediction methods. However, the existing feature selection methods based on linear correlation analysis can not well depict the nonlinear correlation between data features, which results in low accuracy of feature selection. The feature selection methods based on nonlinear correlation analysis are computationally expensive, which affects the timeliness of feature selection. To solve the problem, we propose a parallel feature selection method NX-Spark-DC based on the Spark platform for typhoon trajectory related data. The method firstly filters out the redundant features of typhoon related data by Normalized Mutual Information (NMI) method, subsequently eliminates the useless features by XGBoost machine learning model, and thus reducing the dimension of typhoon related data. On this basis, an improved Spark-based parallel distance correlation algorithm (Spark-DC) is proposed to select the feature combinations with strong correlation. A series of experimental results show that NX-Spark-DC method has high execution efficiency and accuracy, which is significantly better than the existing methods.
A Chinese Collaborative Model for Accelerating Neurofibromatosis Type 1-Associated Research
Authors: Chung Man-Hon , Li Yuehua , Wang Wei , Gu Yihui , Wei Chengjiang , Aimaier Rehanguli , Li Qingfeng , Wang Zhichao 
Published: January 2023

Abstract
Neurofibromatosis type 1 (NF1) is a genetic disorder that affects multiple organ systems. Establishing a multidisciplinary center becomes essential for NF1 management. This study aims to introduce the progress and patient characteristics of the largest NF1 center in China. We retrieved NF1 patient data from 2013 to 2021, including basic personal information, date and department of first admission, location of tumors, and number of re-admission. A total of 725 patients were enrolled in this study, with a mean age of 23.8 years old. Patients were primarily admitted at the age of adolescence and young adulthood. There was not much difference in the number of male and female patients, despite more male patients being observed in adolescence. Both marital and occupational status were negatively affected by the disease. The number of patients admitted each year revealed an increasing trend in general. Regarding deep-seated tumors, 77.6% occurred in the head and neck region, and 3.8% were NF1-associated MPNSTs. Almost a quarter of patients were re-admitted after the first admission, and the mean re-admission time interval was 1.5 years. In summary, we developed the largest multidisciplinary NF1 healthcare center in China, which enables Chinese NF1 patients to access more appropriate healthcare, thereby alleviating the socioeconomic burden of disease among patients.
Dynamic high-pressure microfluidization of pea dietary fiber: Modified structural and adsorption properties and interaction with chlorogenic acid
Authors: Ji Wei , Sheng Guihua , Nan Xijun , Wang Honglei , Li Jiayi , Zhou Quancheng 
Published: January 2023

Abstract
In this study, pea dietary fiber (PDF) was modified by dynamic high-pressure microfluidization (DHPM) technology with the aim to reveal the modulation of the structural and adsorption properties of PDF under different pressures. In addition, pea dietary fiber–chlorogenic acid complexes (PDF-CA) after DHPM treated were obtained, to further investigate the interaction between PDF and CA, and synergistic action of CA and DHPM on PDF. Due to the molecular interplay of PDF-CA, the results showed that PDF and PDF-CA samples with different particle sizes could be obtained after DHPM treatment. Microscopic evaluation of PDF and complexes also showed significant morphological changes; the crystallinity of both PDF and complexes decreased during the treatment, but the trend of thermal stability showed a different shift. In addition, the DHPM treatment made the samples exhibit better water- and oil-holding properties, enhanced their ability to bind glucose and cholesterol, and gradually enhanced the adsorption capacity with increasing pressure. These results illustrated that the structural and adsorption properties of PDF could be effectively modified by DHPM and CA.
Real-life evaluation of NIV to CPAP switch in patients with chronic respiratory failure. A case control study.
Authors: Mathieu Louise , Rabec Claudio , Beltramo Guillaume , Aho Ludwig S. , Tankere Pierre , Schenesse Déborah , Chorvoz Jade , Bonniaud Philippe , Georges Marjolaine 
Published: January 2023

Abstract

Background
Non-invasive ventilation (NIV) is a standard of care for hypercapnic chronic respiratory failure (CRF). Obstructive sleep apnea (OSA) frequently contribute to hypoventilation in CRF. CPAP improves hypercapnia in selected COPD and obese patients. We describe the profile of patients switching from NIV to CPAP in a cohort of patients on long-term NIV and identify factors associated with a successful switch.
Methods
The observational research protocol evaluation committee of the French Pneumology Society approved this case-control study (CEPRO 2022-015). We compared 88 consecutive candidates for a NIV-CPAP switch with 266 controls among 394 ventilated patients treated at the Dijon University Hospital between 2015 and 2020. They followed a standardized protocol including a poly(somno)graphy recorded after NIV withdrawal for three nights. CPAP trial was performed if severe OSA was confirmed. Recurrent hypoventilation was checked after one night and one month under CPAP.
Results
Patients were 53% males, median age 65 [56–74] years, and median BMI 34 [25-38.5] kg/m2. Sixty seven percent of patients were safely switched and remained on CPAP. The probability of a NIV-CPAP switch was correlated to older age (OR:1.3 [1.01–1.06]), CRF etiology (OR for COPD:20.37 [4.2–98,72], obesity:7.31 [1.58–33.74]), circumstances of NIV initiation (OR for acute exacerbation:11.64 [2.03–66.62]), lower pressure support (OR:0.90 [0.73–0.92]), lower baseline PaCO2 (OR:0.85 [0.80–0.91]) and lower compliance (OR:0.76 [0.64–0.90]). Pressure support level was the only factor associated with the outcome of the NIV-CPAP switch.
Conclusions
A NIV-CPAP switch is possible in real life conditions in stable obese and COPD patients with underlying OSA.
À la carte, Streptococcus pneumoniae capsular typing: using MALDI-TOF mass spectrometry and machine-learning algorithms as complementary tools for the determination of PCV13 serotypes and the most prevalent NON PCV13 serotypes according to Argentina’s epidemiology
Authors: Zintgraff Jonathan , Rocca Florencia , Eluchans Nahuel Sánchez , Irazu Lucía , Moscoloni Maria Luisa , Lara Claudia , Santos Mauricio 
Published: January 2023

Abstract

Laboratory surveillance of Streptococcus pneumoniae serotypes is crucial for the successful implementation of vaccines to prevent invasive pneumococcal diseases. The reference method of serotyping is the Quellung reaction, which is labor-intensive and expensive. In the last few years, the introduction of MALDI-TOF MS into the microbiology laboratory has been revolutionary. In brief, this new technology compares protein profiles by generating spectra based on the m/z ratio. We evaluated the performance of MALDI-TOF MS for typing serotypes of S. pneumoniae isolates included in the PCV13 vaccine using a machine learning approach. We challenged our classification algorithms in “real time” with a total of new 100 isolates of S. pneumoniae from Argentinian nationwide surveillance. Our best approach could correctly identify the isolates with a sensitivity of 58.33% ([95%IC 40.7–71.7]); specificity of 81.48% ([95%IC 53.6–79.7]); accuracy of 63.0% ([95%IC 61.9–93.7]); PPV of 80.77% ([95%IC 64.5–90.6]) and NPV of 59.46% ([95%IC 48.9–69.2]). In this work, it was possible to demonstrate that the combination of MALDI-TOF mass spectrometry and multivariate analysis allows the development of new strategies for the identification and characterization of Spn isolates of clinical importance.
Knowledge, Attitude and Practices with respect to Sports Nutrition of Elite Cricketers from India and Impact Evaluation of Nutrition Education Module
Authors: Deota Prachi , Chandorkar Suneeta 
Published: January 2023

Abstract

Purpose Basic sport-specific nutrition knowledge of an athlete can result in better nutrition-based choices. Therefore, it is imperative to explore the existing knowledge, practices and attitude of athletes toward Sports Nutrition and address the gaps if any.
Methods The study was conducted on elite cricketers (n=81; 54 males, 27 females) from urban Vadodara, India. The existing knowledge, attitude and practices of the athletes w.r.t sports nutrition were recorded by administering a semi-structured questionnaire. Based on the identified gaps, a nutrition education booklet was developed and distributed to the participants which was followed by daily reinforcement of the key messages for 21 days. The impact evaluation of the intervention was assessed after a washout period of 2 months.
Results Over 89.3% of the respondents indicated that nutrition support is critical in their sport and over 86.7% believed that a nutritionist should be a member of the sports professionals' team. Only about 21% of the participants consumed solid foods within the recommended period of 30 minutes after the match, which is the window of recovery. In all the squads the post-intervention knowledge scores improved compared to the pre-intervention scores (p=0.000). All the participants consumed some or the other form of supplements; Sports drinks were consumed by 96% of the participants, protein by 44% and BCAA by 3%.
Conclusion The key knowledge deficit areas of the cricketers at the baseline showed significant improvement post-intervention across all the 3 squads thus emphasising the need and benefit of nutrition education for athletes.
On generalized eigenvalue problems of fractional $(p,q)$-Laplace operator with two parameters
Authors: Biswas Nirjan , SK Firoj 
Published: January 2023

Abstract
For s1, s2 ∈ (0, 1) and p, q ∈ (1,∞), we study the following nonlinear Dirichlet eigenvalue
problem with parameters α, β ∈ R driven by the sum of two nonlocal operators:
(−Δ)s1p u + (−Δ)s2q u = α|u|p−2u + β|u|q−2u in Ω, u = 0 in Rd \ Ω,
where Ω ⊂ Rd is a bounded open set. Depending on the values of α, β, we investigate the existence and non-existence of positive solutions to the above problem. A continuous curve in the two-dimensional (α, β)-plane is constructed, which separates the regions of the existence and non-existence of positive solutions. In addition, we prove that the first Dirichlet eigenfunctions of the fractional p-Laplace and fractional q-Laplace operators are linearly independent.
Can paracetamol alter the reproduction regulatory axis of a male Neotropical catfish? A multibiomarker approach
Authors: Perussolo Maiara Carolina , Vicentini Maiara , Lyra Leonardo Skarbek , Silva Lucicleide Ângelo , Rodrigues Mayara dos Santos , Fernandes Leticia Pereira , Fávaro Luis Fernando , Assis Helena Cristina Silva 
Published: January 2023

Abstract

Paracetamol (PCM), or acetaminophen, is one of the most used drugs for human treatment and has been found contaminating the aquatic environment. Besides, it can affect the aquatic biota. The aim of this study was to investigate the effects of PCM in the male catfish Rhamdia quelen reproductive axis after 14 days of exposure. Different biomarkers were evaluated in hypothalamus, liver and gonads, as well as sexual hormone levels. The fish were exposed to solvent (acetone 0.0003%; control group) and to three PCM concentrations: 0.25, 2.5 and 25 µg.L-1, based on environmental concentrations. After the exposure period, they were anesthetized for blood sampling and biometrics and euthanized for tissues collection. From blood, it was obtained plasma for 11 – keto testosterone and 17β – estradiol hormones quantification. The hypothalamus was collected for brain aromatase (cyp19a1b) gene expression; the liver for the vitellogenin (vtg) gene expression and biochemical biomarkers; and gonad for the biochemical and histological biomarkers analyses. No alterations were observed in the hormones levels, sexual maturation or in cyp19a1b and vtg gene expression. In the liver, the non-protein thiols concentration and the superoxide dismutase (SOD) activity were altered. In gonads, glutathione S-transferase (GST), SOD and glutathione peroxidase (GPx) activities changed. The results showed that PCM environmental concentrations can cause alterations in the antioxidant system, mainly in the R. quelen male gonads under the tested conditions. However, no significant changes of hormones levels or the expression of genes related to the reproduction axis were observed.
Diagnostic Accuracy of Plain Computed Tomography (CT) to detect the Morphological Variations of Liver: An update
Authors: Muraleedharan Aparna , Ragavan Saranya , Nayakar Gopinath , Bage Nutan Nalini , Devi Rema , Phansalkar Dilip Shankar 
Published: January 2023

Abstract
Introduction
The prevalence of accessory fissures in the liver ranges from 6% - 56%, as reported by cadaveric studies, which is much higher than the prevalence of 25% on CT scans. Despite reporting many morphological variations in the liver by various cadaveric studies worldwide, the imaging studies are very few. Radiological imaging of patients undergoing liver surgery is a routine preoperative investigation. Despite there are several occasions where liver variations occur as a surprise during surgery which reflects on the diagnostic capacity of CT.
Materials & Methods
60 cadaveric livers removed and stored in 10% Formalin were studied for all morphological abnormalities. The same livers were analysed separately by anatomists using gross examination and radiologists using plain CT imaging. The radiologist reporting the CT findings was blinded from the gross examination findings. The data obtained by both methods were compared by using appropriate statistical methods and the diagnostic accuracy of CT was estimated.
Results
The common surface morphological variations detected were accessory fissures, accessory lobes, pons hepatis and multilobed caudate and quadrate lobes. Out of the total 89 accessory fissures identified by gross examination, only 73 could be detected by CT scan, thus the sensitivity of CT scan in detecting accessory fissures is 82%. Similarly, sensitivity of CT scan in detecting accessory lobes, pons hepatis, and multilobed caudate and quadrate lobe was calculated as 64% (low), 81% and 19% (very low) respectively. Thus, plain CT has variable sensitivity depending on the morphological variation.
Conclusions
This study has highlighted some of the diagnostic inaccuracies that may arise during plain CT examination of liver in a person posted for liver surgery or a person with abdominal trauma. Contrast-enhanced CT scans can circumvent many of these problems. Lack of awareness of these issues may affect the normal course of treatment and prognosis in such patients.
Demodex Prevalence in Mine, Textile and Food Factory Workers with Dermatosis: a cross‐sectional, multicenter study
Authors: Metin Zuhal , Akca Hanife Merve , Ozkoca Defne , Imren Isıl Gogem , Durmaz Koray , Kara Kevser Tuncer , Metin Mahmut Sami , Temiz Selami Aykut , Caf Nazli , Ozyurt Kemal 
Published: January 2023

Abstract
Demodex, a type of mite, lives in human hair follicles. They can multiply very quickly in some conditions and then start to irritate the skin by causing skin disorders. This study aims to compare if working conditions affect the workers' Demodex prevalence so their skin health. A cross-sectional, multicentre study was conducted with three different occupational groups: Mine, Textile and Food Factory Workers (n=102). Determined industry workers who applied to our outpatient dermatology clinics with the complaint of dermatosis in three different cities were included in the study. Demodex positivity was checked by dermoscopy. Differences between categorical variables examined with Chi-square analysis and T test was used to compare continuous variables between groups. 50% Demodex positivity was found in mine workers, %45,3 in food factory workers and 66,7% in textile manufacturing workers. A high rate of Demodex positivity was observed in all three occupational groups. Although the highest positivity rate was observed in textile manufacturing workers, no significant difference was found between the groups (p=0.320). The overall prevalence of Demodex in female workers was statistically significantly higher than in male workers (p=0.029). Exposure of workers to a wide variety of factors in work environments such as textile factories and the fact that women are more sensitive to external factors may have caused the prevalence of Demodex to be higher in these groups. So, a change in the work environment or the use of suitable protective equipment may benefit the treatment of diseases caused by Demodex. But, further studies are needed with larger and various industry groups to make more certain views.