bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cigarette smoke extract impairs gingival epithelial barrier function
Authors: Yamaga Shunsuke , Tanigaki Keita , Nakamura Eriko , Sasaki Naoko , Kato Yuta , Kuboniwa Masae , Matsusaki Michiya , Amano Atsuo , Takeuchi Hiroki 
Published: June 2023

AbstractWe previously showed that junctional adhesion molecule 1 (JAM1) and coxsackievirus and adenovirus receptor (CXADR), tight junction-associated proteins, have important roles to maintain epithelial barrier function in gingival tissues. Smoking is considered to be a significant risk factor for periodontal disease. The present study was conducted to examine the effects of cigarette smoke extract (CSE) on JAM1 and CXADR in human gingival epithelial cells. CSE was found to cause translocation of JAM1 from the cellular surface to EGFR-positive endosomes, whereas CXADR did not. Using a three-dimensional multilayered gingival epithelial tissue model, CSE administration was found to increase permeability to lipopolysaccharide and peptidoglycan, whereas overexpression of JAM1 in the tissue model prevented penetration by those substrates. Furthermore, vitamin C increased JAM1 expression, and inhibited penetration of LPS and PGN induced by CSE. These findings strongly suggest that CSE disrupts gingival barrier function via dislocation of JAM1, thus allowing bacterial virulence factors to penetrate into subepithelial tissues. Furthermore, they indicate that vitamin C increases JAM1 expression and prevents disruption of gingival barrier function by CSE.
Association of systemic adverse reaction patterns with long-term dynamics of humoral and cellular immunity after coronavirus disease 2019 third vaccination
Authors: Yoshida Makoto , Kobashi Yurie , Kawamura Takeshi , Shimazu Yuzo , Nishikawa Yoshitaka , Omata Fumiya , Saito Hiroaki , Yamamoto Chika , Zhao Tianchen , Takita Morihiro , Ito Naomi , Tatsuno Kenji , Kaneko Yudai , Nakayama Aya , Kodama Tatsuhiko , Wakui Masatoshi , Takahashi Kenzo , Tsubokura Masaharu 
Published: June 2023

AbstractThe objective of this study was to clarify the impact of adverse reactions on immune dynamics. We investigated the pattern of systemic adverse reactions after the second and third coronavirus disease 2019 (COVID-19) vaccinations and their relationship with immunoglobulin G against severe acute respiratory syndrome coronavirus 2 spike 1 protein titers, neutralizing antibody levels, peak cellular responses, and the rate of decrease after the third vaccination in a large-scale community-based cohort in Japan. Participants who received a third vaccination with BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna), had two blood samples, had not had COVID-19, and had information on adverse reactions after the second and third vaccinations (n = 2198) were enrolled. We collected data on sex, age, adverse reactions, comorbidities, and daily medicine using a questionnaire survey. Participants with many systemic adverse reactions after the second and third vaccinations had significantly higher humoral and cellular immunity in the peak phase. Participants with multiple systemic adverse reactions after the third vaccination had small changes in the geometric values of humoral immunity and had the largest geometric mean of cellar immunity in the decay phase. Systemic adverse reactions after the third vaccination helped achieve high peak values and maintain humoral and cellular immunity. This information may help promote uptake of a third vaccination, even among those who hesitate due to adverse reactions.
Country-level predictors of COVID-19 mortality
Authors: Brown Paul A. 
Published: June 2023

AbstractThis study aimed to identify country-level predictors of COVID-19 mortality, after controlling for diverse potential factors, and utilizing current worldwide mortality data. COVID-19 deaths, as well as geographic, demographic, socioeconomic, healthcare, population health, and pandemic-related variables, were obtained for 152 countries. Continuous variables were examined with Spearman’s correlation, categorical variables with ANOVA or Welch’s Heteroscedastic F Test, and country-level independent predictors of COVID-19 mortality identified by weighted generalized additive models. This study identified independent mortality predictors in six limited models, comprising groups of related variables. However, in the full model, only WHO region, percent of population ≥ 65 years, Corruption Perception Index, hospital beds/100,000 population, and COVID-19 cases/100,000 population were predictive of mortality, with model accounting for 80.7% of variance. These findings suggest areas for focused intervention in the event of similar future public health emergencies, including prioritization of the elderly, optimizing healthcare capacity, and improving deficient health sector-related governance.
In-vitro and in-silico evidence for oxidative stress as drivers for RDW
Authors: Joosse Huibert-Jan , van Oirschot Brigitte A. , Kooijmans Sander A. A. , Hoefer Imo E. , van Wijk Richard A. H. , Huisman Albert , van Solinge Wouter W. , Haitjema Saskia 
Published: June 2023

AbstractRed blood cell distribution width (RDW) is a biomarker associated with a variety of clinical outcomes. While anemia and subclinical inflammation have been posed as underlying pathophysiology, it is unclear what mechanisms underlie these assocations. Hence, we aimed to unravel the mechanisms in silico using a large clinical dataset and validate our findings in vitro. We retrieved complete blood counts (CBC) from 1,403,663 measurements from the Utrecht Patient Oriented Database, to model RDW using gradient boosting regression. We performed (sex-stratified) analyses in patients with anemia, patients younger/older than 50 and validation across platforms and care settings. We then validated our hypothesis regarding oxidative stress using an in vitro approach. Only percentage microcytic (pMIC) and macrocytic (pMAC) erythrocytes and mean corpuscular volume were most important in modelling RDW (RMSE = 0.40, R2 = 0.96). Subgroup analyses and validation confirmed our findings. In vitro induction of oxidative stress underscored our results, namely increased RDW and decreased erythrocyte volume, yet no vesiculation was observed. We found that erythrocyte size, especially pMIC, is most informative in predicting RDW, but no role for anemia or inflammation. Oxidative stress affecting the size of the erythrocytes may play a role in the association between RDW and clinical outcomes.
Autonomic responses during bladder hydrodistention under general versus spinal anaesthesia in patients with interstitial cystitis/bladder pain syndrome: a randomized clinical trial
Authors: Kim Yoon Jung , Yoon Hyun-Kyu , Kang Yu Jin , Oh Seung-June , Hur Min , Park Hee-Pyoung , Lee Hyung-Chul 
Published: June 2023

AbstractBlocking the abrupt increase in systolic blood pressure associated with autonomic response during bladder hydrodistention in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) is essential for patient safety. We conducted this study to compare autonomic responses during bladder hydrodistention in patients with IC/BPS under general and spinal anaesthesia. Thirty-six patients were randomly allocated to a general anaesthesia (GA, n = 18) or a spinal anaesthesia (SA, n = 18) group. Blood pressure and heart rate were measured continuously and ΔSBP, defined as maximum increases in SBP during bladder hydrodistention from baseline, was compared between groups. Heart rate variability was analysed using electrocardiograms. The post-anaesthesia care unit assessed postoperative pain using a numeric (0–10) rating scale. Our analyses yield a significantly greater ΔSBP (73.0 [26.0–86.1] vs. 2.0 [− 4.0 to 6.0] mmHg), a significantly lower root-mean-square of successive differences in heart rate variability after bladder hydrodistention (10.8 [7.7–19.8] vs. 20.6 [15.1–44.7] ms), and significantly higher postoperative pain scores (3.5 [0.0–5.5] vs. 0.0 [0.0–0.0]) in the GA compared to the SA group. These findings suggest that SA has advantages over GA for bladder hydrodistention in preventing an abrupt increase in SBP and postoperative pain in IC/BPS patients.
Intra-population genomic diversity of the bloom-forming cyanobacterium, Aphanizomenon gracile, at low spatial scale
Authors: Halary Sébastien , Duperron Sébastien , Kim Tiam Sandra , Duval Charlotte , Bernard Cécile , Marie Benjamin 
Published: June 2023

Abstract
Cyanobacteria are oxygenic photosynthetic bacteria that perform a substantial part of the global primary production. Some species are responsible for catastrophic environmental events, called blooms, which have become increasingly common in lakes and freshwater bodies as a consequence of global changes. Genotypic diversity is considered essential for marine cyanobacterial population, allowing it to cope with spatio-temporal environmental variations and to adapt to specific micro-niches in the ecosystem. This aspect is underestimated in the study of bloom development, however, and given little notice in studies of the ecology of harmful cyanobacteria. Here we compared the genomes of four strains of Aphanizomenon gracile, a species of filamentous toxinogenic cyanobacteria (Nostocales) found worldwide in fresh and brackish water. Millimeter-sized fascicles were isolated from a single water sample and have been maintained in culture since 2010. A comparative study revealed extensive heterogeneity in gene contents, despite similar genome size and high similarity indices. These variations were mainly associated with mobile genetic elements and biosynthetic gene clusters. For some of the latter, metabolomic analysis confirmed the production of related secondary metabolites, such as cyanotoxins and carotenoids, which are thought to play a fundamental role in the cyanobacterial fitness. Altogether, these results demonstrated that an A. gracile bloom could be a highly diverse population at low spatial scale and raised questions about potential exchanges of essential metabolites between individuals.
Predictors for Augmentative and Alternative Communication Clinical Service Provision: Closing the Gap
Authors: Johnson Rachel K. , Gohsman Meredith K. 
Published: June 2023

Purpose:
At the core of the clinical services provided by a speech-language pathologist (SLP) is upholding the human right to communicate. Augmentative and alternative communication (AAC) modalities support communication across environments by offering temporary or permanent solutions. Barriers to AAC service provision include translation of knowledge into clinical practice, which remains problematic despite changes to AAC preservice training addressing the knowledge barrier. This study aims to understand the importance of factors impacting the provision of AAC clinical services.

Method:

From the survey data of SLPs (
N
= 530) regarding current AAC service delivery practices, barriers, and professional development preferences in the United States, a hierarchical multiple regression identified the importance between individual and clinical practice variables of knowledge and current use of AAC modalities. A binomial logistic regression predicted the probability of one or more independent variables for barriers to AAC service delivery and learning preferences for AAC-related professional development.

Results:
The factors impacting SLPs' knowledge and barriers to practice are related to clinical practicum experiences. Engagement in AAC-related continuing education (CE) is the primary contributor to the use of AAC service provision. Predictors for barriers to AAC clinical provision are associated with clinical practicum experiences, the average number of patients seen weekly, and geographic region. Preference for CE topics and frequency depend on the work setting.

Conclusions:
Hands-on clinical practicum experience addresses opportunity barriers in AAC service provision, contributing explicitly to the value of collaboration in AAC service delivery and highlights the importance of evidence-based professional development content. The findings from this study are reassuring in that clinicians are using AAC and suggest that high-quality professional development is an effective means to address the gap between knowledge generation and translation in the field.

Supplemental Material:

https://doi.org/10.23641/asha.23202170
A joint denoising and deep learning detector for OFDM‐IM
Authors: Duan Sirui , Liu Jiancheng , Pang Yucai , Yu Xiang , Wu Chao 
Published: June 2023

AbstractOnly a subset of subcarriers are activated in orthogonal frequency division multiplexing‐index modulation (OFDM‐IM), which achieves higher energy efficiency and resists frequency offset. In the OFDM‐IM, the energy of the received signal is computed and then combined with pre‐processed signal to create the input of detection network. Inspired by image denoising technology, this study enhances the detection performance by denoising the pre‐processed data and improving the energy distribution in the OFDM‐IM system. First, considering that the noise reduction process of the pre‐processed signal can effectively mitigate the distortion by noise which affects the detection accuracy, this study proposes a two‐phase neural network termed as Deep‐Denoising‐IM through the combination of a noise reduction network and a deep learning detection method. Then, to better determine the position of the active carriers, a joint decision method of the denoised data and the received signal is designed as the IQ signal of the denoised data may change the quadrant of original signal distribution. In addition, the pre‐processed data sample has insufficient diversity. Considering that data enhancement can increase the noise of the signal samples, this study proposes a method to strengthen the silent carriers in the model training phase, which improves the generalization ability of the model and further enhances the denoising performance. Simulation results show that Deep‐Denoising‐IM outperforms the existing detectors in terms of mean square error (MSE) and bit error rate (BER) under the Rayleigh fading channel.
Performance analysis of uplink optical wireless communications in the presence of a simultaneously transmitting and reflecting reconfigurable intelligent surface
Authors: Salehiyan Alireza , Emadi Mohammad Javad 
Published: June 2023

AbstractRecently, reconfigurable intelligent surface (RIS) has gained research and development interests in modifying wireless channel characteristics in order to improve the performance of wireless communications, especially when the quality of the line‐of‐sight channel is not that good. In this work, for the first time in the literature, we have used simultaneously transmitting and reflecting RIS (STAR‐RIS) in a non‐orthogonal multiple‐access visible light communication system to improve the performance of the system. Achievable rates of the users are derived for two data recovery schemes, single‐user detection (SUD) and successive interference cancellation (SIC). Then, the sum‐rate optimisation problem is formulated for two operating modes of STAR‐RIS, namely energy‐splitting and mode‐switching cases. Moreover, a sequential parametric convex approximation method is used to solve the sum‐rate optimisation problems. The authors have also compared energy‐splitting and mode‐switching cases and showed that these two modes have the same performance. Finally, numerical results for SUD and SIC schemes and two benchmarking schemes, time‐sharing and max‐min fairness, are presented, and spectral‐ and energy‐efficiency, number of STAR‐RIS elements, the position of users, and access point are discussed.
Un historien en interdisciplinarité. Essai d’épistémologie située
Authors: Cornu Pierre 
Published: June 2023

L’essor de la question environnementale dans la recherche française depuis les années 1990 s’est accompagné à la fois d’un fort développement de l’interdisciplinarité et d’une convocation sans cesse plus pressante de l’histoire, d’abord comme récit, ensuite comme méthode. Cette contribution se propose d’analyser ce processus au prisme d’une trajectoire située, celle de l’auteur, historien de métier progressivement intégré à une communauté épistémique formée autour des approches interdisciplinaires des relations entre natures, sciences et sociétés, et amené à y partager l’heuristique du récit comme élucidation de « ce qui arrive au temps » dans l’anthropocène.
Follow-Up and Outcome after Coronary Bypass Surgery Preceded by Coronary Stent Implantation
Authors: Hamiko Marwan , Konrad Nicole , Lagemann Doreen , Gestrich Christopher , Masseli Franz , Oezkur Mehmet , Velten Markus , Treede Hendrik , Duerr Georg Daniel 
Published: June 2023

Abstract
Background Guidelines on myocardial revascularization define recommendations for percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. Only little information exists on long-term follow-up and quality of life (QoL) after CABG preceded by PCI. The aim of our study was to evaluate the impact of prior PCI on outcome and QoL in patients with stable coronary artery disease who underwent CABG.
Methods In our retrospective study, CABG patients were divided in: CABG preceded by PCI: PCI-first (PCF), and CABG-only (CO) groups. The PCF group was further divided in guideline-conform (GCO) and guideline nonconform (GNC) subgroups, according to the SYNTAX score (2014 European Society of Cardiology [ESC]/European Association for Cardio-Thoracic Surgery [EACTS] guidelines). Thirty days mortality, major adverse cardiac events, and QoL using the European Quality-of-Life–5 Dimensions were evaluated.
Results A total of 997 patients were analyzed, of which 784 underwent CABG without (CO), and 213 individuals with prior PCI (PCF). The latter group consisted of 67 patients being treated in accordance (GCO), and 24 in discordance (GNC) to the 2014 ESC/EACTS guidelines. Reinfarction (PCF: 3.8% vs. CO: 1.0%; p = 0.024), re-angiography (PCF: 17.6% vs. CO: 9.0%; p = 0.004), and re-PCI (PCF: 10.4% vs. CO: 3.0%; p < 0.001) were observed more frequently in PCF patients. Also, patients reported better health status in the CO compared to PCF group (CO: 72.48 ± 19.31 vs. PCF: 68.20 ± 17.86; p = 0.01). Patients from the guideline nonconform subgroup reported poorer health status compared to the guideline-conform group (GNC: 64.23 ± 14.56 vs. GCO: 73.42 ± 17.66; p = 0.041) and were more likely to require re-PCI (GNC: 18.8% vs. GCO: 2.4%; p = 0.03). Also, GNC patients were more likely to have left main stenosis (GCO: 19.7% vs. GNC: 37.5%; p < 0.001) and showed higher preinterventional SYNTAX score (GCO: 18.63 ± 9.81 vs. GNC: 26.67 ± 5.07; p < 0.001).
Conclusion PCI preceding CABG is associated with poorer outcomes such as reinfarction, re-angiography, and re-PCI, but also worse health status and higher rehospitalization. Nevertheless, results were better when PCI was guideline-conformant. This data should impact the Heart Team decision.
Unilateral Lung Agenesis: A Case Series and Review of Literature
Authors: Weber Jennifer , Sati Sunil Kumar , Karody Vijender Rao 
Published: June 2023

AbstractUnilateral lung agenesis is a rare congenital abnormality that typically presents with respiratory distress after birth. Prognostic factors include the side of the lung affected along with the presence or absence of other congenital abnormalities. Prenatal imaging can make the diagnosis that can assist the healthcare team in preparing to care for the neonate, as well as set expectations for the family. In this case series, we describe three cases of unilateral lung agenesis, two infants with right lung agenesis, and one with the left. We describe their presentation, provide a brief clinical course, and discuss outcomes.
Is Increasing Parity Associated with Adverse Perinatal Outcomes in Dichorionic Twin Gestations?
Authors: Rao Manasa G. , Debolt Chelsea A. , Wang Kelly , Khurana Sonia G. , Mills Alexandra N. , Paul Keisha , Vieira Luciana , Rebarber Andrei , Fox Nathan S. , Stone Joanne 
Published: June 2023

Objective Dichorionic twins have increased risk of preterm birth and hypertensive disorders of pregnancy. Grand multiparity may be associated with adverse perinatal outcomes in singleton pregnancies, although the effect of increasing parity in twins is unclear. This study aimed to elucidate whether grand multiparity leads to adverse outcomes in dichorionic twins compared with multiparity and nulliparity.
Study Design This was a retrospective review of dichorionic twins at a single institution between January 2008 and December 2019 comparing pregnancy outcomes among grand multiparity, multiparity, and nulliparity. Primary outcome was preterm birth less than 37 weeks. Multivariable regression controlled for differing demographics, prior preterm birth, use of reproductive technologies, and hypertensive disorders of pregnancy. Chi square and Fisher's exact were used for categorical variables and Kruskal–Wallis was used for continuous variables.
Results A total of 843 (60.3%) pregnancies were nulliparous, 499 (35.7%) multiparous, and 57(4.1%) grand multiparous. Univariate analysis indicated that multiparous women had lower incidence of preterm birth less than 37, 34, and 32 weeks (57 vs. 51%, p = 0.04; 19.2 vs. 14.0%, p = 0.02; 9.6 vs. 5.6%, p = 0.01) and that grand multiparous women had lower incidence of preterm birth less than 34 weeks (19.2 vs. 5.3%, p = 0.008) compared with nulliparous women. Multivariable regression confirmed multiparous women had lower odds of preterm birth less than 34 and 32 weeks compared with nulliparous women (<34 wk: odds ratio [OR] = 0.69, 95% confidence interval [CI] = 0.49–0.97, p = 0.03; <32 wk: OR = 0.48, 95% CI = 0.29–0.79, p = 0.004) and that multiparous women (OR = 0.57, 95% CI = 0.42–0.77, p = 0.0002) and grand multiparous women (OR = 0.23, 95% CI = 0.08–0.68, p = 0.0074) had lower incidence of hypertensive disorders of pregnancy when compared with nulliparous women.
Conclusion Grand multiparity is not associated with adverse perinatal outcomes compared with nulliparity or multiparity in dichorionic twins. Increasing parity may protect against incidence of preterm birth and hypertensive disorders of pregnancy even among grand multiparous women.
Key Points