bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a Deep Learning Algorithm for Continuous, Real‐Time Detection of Atrial Fibrillation Using a Wrist‐Worn Device in an Ambulatory Environment
Authors: Poh Ming‐Zher , Battisti Anthony J. , Cheng Li‐Fang , Lin Janice , Patwardhan Anil , Venkataraman Ganesh S. , Athill Charles A. , Patel Nimesh S. , Patel Chinmay P. , Machado Christian E. , Ellis Jeffrey T. , Crosson Lori A. , Tamura Yuriko , Plowman R. Scooter , Turakhia Mintu P. , Ghanbari Hamid 
Published: September 2023

Background
Wearable devices may be useful for identification, quantification and characterization, and management of atrial fibrillation (AF). To date, consumer wrist‐worn devices for AF detection using photoplethysmography‐based algorithms perform only periodic checks when the user is stationary and are US Food and Drug Administration cleared for prediagnostic uses without intended use for clinical decision‐making. There is an unmet need for medical‐grade diagnostic wrist‐worn devices that provide long‐term, continuous AF monitoring.

Methods and Results

We evaluated the performance of a wrist‐worn device with lead‐I ECG and continuous photoplethysmography (Verily Study Watch) and photoplethysmography‐based convolutional neural network for AF detection and burden estimation in a prospective multicenter study that enrolled 117 patients with paroxysmal AF. A 14‐day continuous ECG monitor (Zio XT) served as the reference device to evaluate algorithm sensitivity and specificity for detection of AF in 15‐minute intervals. A total of 91 857 intervals were contributed by 111 subjects with evaluable reference and test data (18.3 h/d median watch wear time). The watch was 96.1% sensitive (95% CI, 92.7%–98.0%) and 98.1% specific (95% CI, 97.2%–99.1%) for interval‐level AF detection. Photoplethysmography‐derived AF burden estimation was highly correlated with the reference device burden (
R
2
=0.986) with a mean difference of 0.8% (95% limits of agreement, −6.6% to 8.2%).

Conclusions
Continuous monitoring using a photoplethysmography‐based convolutional neural network incorporated in a wrist‐worn device has clinical‐grade performance for AF detection and burden estimation. These findings suggest that monitoring can be performed with wrist‐worn wearables for diagnosis and clinical management of AF.

Registration Information

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04546763.
Earthly fruitfulness and the gods of nature in Rubens’ imagery
Authors: Mcgrath Elizabeth 
Published: September 2023

This article explores themes of fertility and fecundity in Peter Paul Rubens’ work and investigates their role in a peculiar Rubensian category of subject, somewhere between landscape and myth, which can perhaps be described as ‘mythological genre’. Here we see the ancient gods of nature inhabiting the countryside and engaged in their ‘everyday’ activities, though, as in The feast of Venus (Vienna, Kunsthistorisches Museum), their presence is usually sensed rather than seen by any human characters depicted alongside them.
A particular focus of the article is one of Rubens’ most personal works, the Nymphs and satyrs gathering fruit (Madrid, Museo del Prado). It was his happy invention to give the nymphs, satyrs and even the old Silenus the job of collecting fruit together, to keep the cornucopia – symbol of abundance and fecundity – in a state of constant overflow. It has not been realised, however, that Rubens had a classical source for the idea of Silenus and the satyrs helping the nymphs gather apples: a passage in Propertius’ Elegies (II.32.37-40).
The poetry of Propertius was especially familiar to Rubens’ circle as Justus Lipsius planned an edition of the poet’s work. Moreover, the lines had been the subject of a notable emendation by Joseph Justus Scaliger, as well as an extensive discussion by Lipsius in his Antiquae lectiones (III). Rubens was surely familiar with the Propertius passage, whether he came across it in his reading or in his conversations on ancient literature and customs with his brother, Philip, Lipsius’ favourite pupil. In Nymphs and satyrs, the poet’s lines seem to have helped inspire a joyous celebration of the earth’s fruitfulness by the gods of nature themselves.
The role of magnetic resonance imaging in the management of brain metastases: diagnosis to prognosis
Authors: Zakaria Rasheed , Das Kumar , Bhojak Maneesh , Radon Mark , Walker Carol , Jenkinson Michael D 
Published: September 2023

AbstractThis article reviews the different MRI techniques available for the diagnosis, treatment and monitoring of brain metastases with a focus on applying advanced MR techniques to practical clinical problems. Topics include conventional MRI sequences and contrast agents, functional MR imaging, diffusion weighted MR, MR spectroscopy and perfusion MR. The role of radiographic biomarkers is discussed as well as future directions such as molecular imaging and MR guided high frequency ultrasound.
Association between sun-protective behaviors and hypertension: a cross-sectional study from National Health and Nutrition Examination Survey 2009 to 2014
Authors: Yang Shuping , Dai Feng , Wang Zhaokai , Li Ruoshui , Xu Xianzhi , Li Cheng , Hou Xiancun , Liu Yang , Wang Chaofan , Li Dongye , Li Lei , Xu Tongda 
Published: September 2023

Abstract
Background
In previous studies, sun-protective behaviors increased cardiovascular incidence. Our present article is to further analyze the potential relationship between sun-protective behaviors (staying in the shade, wearing long-sleeved clothing, and applying sunscreen) and hypertension.

Method
The present cross-sectional study evaluated 8,613 participants (aged 20–60 years) from the National Health and Nutrition Examination Survey (NHANES) obtained between 2009 and 2014. We performed multiple logistic regression analysis to examine the relationship between sun-protective behaviors and hypertension. Subgroup analysis was then performed. Multiple linear regression analysis was utilized to examine the relationship of sun-protective behaviors and each sun-protective behavior with systolic and diastolic blood pressure, stratified by sex and race.

Results
A total of 8,613 participants (weighted n = 127,909,475) were applied in our study, including 1,694 hypertensive subjects. Our study demonstrated that sun-protective behaviors of the 2–3 category were associated with increased risk of hypertension, but not with higher systolic and diastolic blood pressure. In subgroup analysis, men, Mexican American, and 25 < BMI ≤ 30 who reported sun-protective behaviors (2–3) were prone to hypertension. Multiple linear regression models showed that non-Hispanic white men with sun-protective behaviors (2–3) were positively associated with systolic and diastolic blood pressure. The association between other-Hispanic men with frequent wearing long-sleeved clothing and diastolic blood pressure was positively correlated.

Conclusion
Sun-protective behaviors of the 2–3 category could increase the incidence of hypertension, but not increase systolic and diastolic blood pressure. We only found that non-Hispanic white men who reported sun-protective behaviors (2–3) were positively associated with systolic and diastolic blood pressure. These findings suggested that excessive sun-protective behaviors should be avoided.
The lowest point of fibula (LPF) could be used as a reliable bony landmark for arthroscopic anchor placement of lateral ankle ligaments ----compared with open Broström procedure
Authors: Xie Xin , Chen Linxin , Fan Cunshuai , Song Shouyi , Yu Yin , Jiao Chen , Pi Yanbin 
Published: September 2023

Abstract
Background
Arthroscopic technique procedures was wide accepted for the treatment of chronic ankle instability (CAI). But little acknowledge was involved to the bony landmarks and anatomic features of different bundles of lateral ligaments under arthroscopic view.

Methods
Sixty patients with acute or chronic lateral ankle ligaments injury (LAI) were collected prospectively, and divided randomly into two groups. In arthroscopic group, the bone tunnels were made on the LPF arthroscopically. And in open group, the bone tunnels were made on the Fibular obscure tubercle (FOT) in open procedure. The inferior bundle of ATFL and Arcuate fibre was also identified reference to the LPF and labeled by a PDS II suture penetration. Following that, The distances of the bone tunnels to the different bony markers were measured and compare between two groups. The penetrating locations of PDS II on the inferior bundle of ATFL and Arcuate fibre were also confirmed intraoperatively. And the safe angle of anchor implantation on the axial view was measured on postoperative CT scan.

Results
The distances of bone tunnel to the fibular tip, the fibular insertion of anterior-inferior tibiofibular ligament (AITFL), and the FOT in arthroscopic and open locating groups were 4.9 ± 2.2 and 6.3 ± 2.2 mm, 13.5 ± 2.7 and 12.4 ± 1.1 mm, 5.8 ± 2.2 and 5.6 ± 1.0 mm, respectively. The distances of bone tunnels to the FOT and fibular tip on 3d-CT view was 4.4 ± 1.5 and 4.6 ± 0.9 mm, 14.4 ± 3.2 and 13.2 ± 1.8 mm in arthroscopic and open group, and there were no significant differences between two groups. The safe angle of arthroscopic anchor placement on the axial plan was ranged from 24.9 ± 6.3o to 58.1 ± 8.0o. The PDS II sutures penetrating on the inferior bundles of ATFL and the arciform fibres were also comfirmed successfully by open visualizaion.The average distance of penetration point to the horizontal line cross the fibular tip was 2.3 ± 2.7 mm (ranged from − 3.1 to 6.0 mm), and to the vertical line cross the FOT was 2.7 ± 2.7 mm (ranged from − 2.5 to 7.5 mm).

Conclusion
Take the lowest point of fibula under arthroscopy (LPF) as a bony reference, we could identify the iATFL under arthroscopic visualization. By this way, we could place the suture anchors properly to the fibular footprint and suture the iATFL fibres successfully.
Laparoscopic hiatal hernia repair for treating patients with massive hiatal hernia and iron-deficiency anaemia
Authors: Aili Aikebaier , Maimaitiming Maimaitiaili , Li Yiliang , Maisiyiti Alimujiang , Wang Zhi , Tusuntuoheti Yusujiang , Abudureyimu Kelimu 
Published: September 2023

Abstract
Background
Massive hiatal hernias may result in extraoesophageal symptoms, including iron-deficiency anaemia. However, the role played by hiatal hernias in iron-deficiency anaemia is not clearly understood. We examined the prevalence of anaemia in patients with massive hiatal hernias and the frequency of anaemia resolution after laparoscopic hiatal hernia repair at long term follow-up.

Methods
Patients who underwent laparoscopic hiatal hernia repair from June 2008 to June 2019 were enrolled in this study. We collected the patients’ demographic and clinical data from their medical records, and compared the pre-surgical and post-surgical findings (at 1 week and 3 months post-surgery). All patients with adequate documentation underwent post-surgical follow-up to evaluate improvements in clinical symptoms and signs.

Results
A total of 126 patients with massive hiatal hernias underwent laparoscopic hiatal hernia repair. Of these, 35 (27.8%) had iron-deficiency anaemia. Anaemia was resolution in all the patients and they had significantly reduced GERD-Q scores at 3 months postoperatively (P<0.01) .The mean follow-up period was 60 months. Iron-deficiency anaemia resolution after hiatal hernia repair was achieved in 93.9% of the patients.

Conclusion
Anaemia is common in patients with massive hiatal hernias, and most of our patients were symptomatic because of their anaemia. Moreover, in patients with massive hiatal hernias, iron-deficiency anaemia resolution is likely after laparoscopic hiatal hernia repair.
Mortality and exacerbations associated with Stenotrophomonas maltophilia in chronic obstructive pulmonary disease. A regional cohort study of 22,689 outpatients
Authors: Rønn Christian , Kamstrup Peter , Eklöf Josefin , Toennesen Louise Lindhardt , Boel Jonas Bredtoft , Andersen Christian Ostergaard , Dessau Ram Benny , Wilcke Jon Torgny , Sivapalan Pradeesh , Ulrik Charlotte Suppli , Jensen Jens-Ulrik Stæhr 
Published: September 2023

Abstract
Objectives
The clinical significance of Stenotrophomonas maltophilia in patients with COPD is poorly understood. We aimed to determine whether a lower respiratory tract culture positive for S. maltophilia in COPD patients was independently associated with increased risk of death and hospitalisation for exacerbation of COPD.

Methods
An observational cohort study following outpatients with COPD in Eastern Denmark between 2010 and 2018, with a follow-up period of five years. Presence of S. maltophilia was treated as a time-varying exposure, where patients were considered exposed at the time of the first isolation of S. maltophilia from the lower respiratory tract. The hazard ratio (HR) of death and hospitalisation for acute exacerbations of COPD was assessed using a Cox proportional hazards regression.

Results
Of the total 22,689 patients 459 (2.0%) had a lower respiratory sample positive for S. maltophilia. A total of 7,649 deaths (S. maltophilia positive: 243 (52.9%) and S. maltophilia negative: 7,406 (34.4%)) and 24,912 hospitalisations for exacerbation of COPD (S. maltophilia positive: 1,100 in 459 patients and S. maltophilia negative: 23,821 in 22,230 patients) were registered during the study period. We found that a lower respiratory tract culture positive for S. maltophilia was associated with both increased mortality: HR 3.3 (95% CI 2.6–4.3), and hospitalisation for exacerbation of COPD: HR 3.4 (95% CI 2.8–4.1).

Conclusions
A lower respiratory tract culture positive for S. maltophilia in COPD patients was associated with a substantially increased mortality and hospitalisation for exacerbation of COPD. Randomised controlled trials are proposed to determine whether S. maltophilia should be the target of antibiotic treatment.
Detection and quantification of Plasmodium falciparum in human blood by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a proof of concept study
Authors: Stauning Marius Ahm , Jensen Christian Salgård , Staalsøe Trine , Kurtzhals Jørgen A. L. 
Published: September 2023

Abstract
Background
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) has revolutionized identification of bacteria and is becoming available in an increasing number of laboratories in malaria-endemic countries. The purpose of this proof-of-concept study was to explore the potential of MALDI-TOF as a diagnostic tool for direct detection and quantification of Plasmodium falciparum in human blood.

Methods
Three different P. falciparum strains (3D7, HB3 and IT4) were cultured and synchronized following standard protocols. Ring-stages were diluted in fresh blood group 0 blood drawn in EDTA from healthy subjects to mimic clinical samples. Samples were treated with saponin and washed in PBS to concentrate protein material. Samples were analysed using a Microflex LT MALDI-TOF and resulting mass spectra were compared using FlexAnalysis software.

Results
More than 10 peaks specific for P. falciparum were identified. The identified peaks were consistent among the three genetically unrelated strains. Identification was possible in clinically relevant concentrations of 0.1% infected red blood cells, and a close relationship between peak intensity and the percentage of infected red blood cells was seen.

Conclusion
The findings indicate that the method has the potential to detect and quantify P. falciparum at clinically relevant infection intensities and provides proof-of-concept for MALDI-TOF-based diagnosis of human malaria. Further research is needed to include other Plasmodium spp., wildtype parasite isolates and to increase sensitivity. MALDI-TOF may be a useful tool for mass-screening purposes and for diagnosis of malaria in settings where it is readily available.
Blind estimation of modulation parameters for PCMA signals using frame cyclic features
Authors: Li Fang , Qiu Zhaoyang , Zha Xiong , Li Tianyun 
Published: September 2023

AbstractBlind receiver technologies for paired carrier multiple access (PCMA) signals have always been a challenging task with many technical difficulties, among which the estimation of modulation parameters is a fundamental but important element. Despite some achievements in previous studies, more systematic and sophisticated estimation methods have not been adequately investigated. In this paper, schemes for the blind estimation of the symbol timing phase, amplitude attenuation, frequency offset, and carrier phase for PCMA signals in satellite communications are proposed. The data flow transmitted in satellite communication often has a certain frame structure, the most important of which is the synchronization data, namely the so-called cycle features. The proposed schemes assume that the modulated signals have fixed frame length and frame sync code and that the symbol rate has been estimated when the signals are encoded asynchronously. Distinct from the previous methods, our schemes exploit the sync waveform and the overlapping waveform, which are estimated via singular value decomposition (SVD) (using the frame cyclic features) and interference cancelation, together with their demodulation results as aid data, for the estimation of the desired parameters. The simulation results demonstrate that the schemes are effective in the parameters estimation of PCMA signals and outperform the comparison algorithms.
Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis
Authors: Wang Xiao-bo , Zhou Long-yun , Chen Xu-qing , Li Ran , Yu Bin-bin , Pan Meng-xiao , Fang Lu , Li Jian , Cui Xue-jun , Yao Min , Lu Xiao 
Published: September 2023

Abstract
Background
Spinal cord injury (SCI) is one of the most disabling neurological conditions, afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species scavenger, is expanding its new scope in field of SCI. The objective of this systematic review is to determine the neuroprotective effects and discuss the underlying mechanism of edaravone in management of SCI.

Methods
The systematic review will include the controlled studies evaluating the neurological roles of edaravone on experiment rat models following SCI. The primary outcome will be the 21-point Basso, Beattie, and Bresnahan locomotor rating scale. The secondary outcomes will include the preservation of white matter areas and malondialdehyde levels. Two researchers will independently search PubMed, Embase, Web of Science, Scopus and Cochrane Library from their inception date. Following study selection, data extraction, and assessment of methodological quality in included studies using the SYRCLE’s RoB tool, data from eligible studies will be pooled and analyzed using random-effects models with RevMan 5.3 software. In case of sufficient data, subgroup analyses with respect to species, age, gender, injury characteristics, or administration details will be carried out to explore the factors modifying efficacy of edaravone. For exploring the appropriate dose of edaravone, a network meta-analysis approach will be conducted based on the Bayesian method. Importantly, the proposed mechanisms and changes of related molecules will be also extracted from included studies for comprehensively investigating the mechanisms underlying the neuroprotective effects of edaravone.

Discussion
In this study, we aim to quantitatively analyze the role of edaravone in locomotor recovery and tissue damage in SCI rat model. The efficacy of edaravone in distinct scenarios will be investigated by subgroup analyses, and we expect to predict the candidate dose that offers a superior treatment effect using network meta-analyses. Moreover, a comprehensive framework regarding the neuroprotective mechanisms behind edaravone will be constructed via a combination of systematic and traditional review. This study will bring implications for future preclinical studies and clinical applications of SCI. Nonetheless, in light of the anticipated limitations in animal experimental design and methodological quality, the results in this review should be interpreted with caution.
Women’s experiences with yoga after a cancer diagnosis: a qualitative meta-synthesis—part I
Authors: Price Jenson , Sharma Sitara , Brunet Jennifer 
Published: September 2023

AbstractBackgroundQualitative research on women’s experiences participating in yoga after a cancer diagnosis is growing; systematic synthesis and integration of results are necessary to facilitate the transfer and implementation of knowledge among researchers and end-users. Thus, the purpose of this meta-synthesis was to: (1) integrate findings from qualitative studies, (2) compare and contrast findings to elucidate patterns or contradictions in conclusions, and (3) develop an overarching interpretation of women’s experiences participating in yoga after a cancer diagnosis.MethodsUsing meta-study methodology, six electronic databases were searched using a sensitive search strategy in November 2020, a supplemental scan of reference lists was conducted in August 2021, and the database search was replicated in October 2021. Two reviewers independently screened titles/abstracts and full-texts to determine eligibility.ResultsThe searches yielded 6804 citations after de-duplication. Data from 24 articles meeting the eligibility criteria were extracted, and the results, methods, and theoretical approach(es) were analyzed. The analysis revealed that there was a predominant focus on two focal points in the primary articles: (1) women’s well-being and quality of life (QoL; part I) and (2) intervention preferences (part II). Five overarching categories emerged related to well-being and QoL: (1) yoga can support improvements in multiple dimensions of QoL in women diagnosed with cancer, (2) women diagnosed with cancer experience an interaction between QoL dimensions, (3) elements of yoga that support improvements in QoL dimensions, (4) breathwork and meditation are integral elements of yoga, and (5) yoga practice may support lifestyle behavior change. The articles reviewed had notable limitations related to: (1) reporting about instructor(s), content of the intervention, and environmental characteristics of the setting, (2) identifying and incorporating optimal features in the intervention design, (3) incorporating theory and real-world considerations into the study procedures, and (4) including positive and negative conceptualizations of QoL as an interconnected and multidimensional concept.ConclusionMoving forward, it remains critical to identify the ideal structure and content of yoga programs for promoting well-being and QoL among women diagnosed with cancer, as well as to explore barriers and facilitators to sustainable program implementation.Systematic review registrationPROSPERO CRD42021229253.