bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipidomic Landscape of Circulating Extracellular Vesicles Isolated from Adolescents Exposed to Ethanol Intoxication: A Sex Difference Study
Authors: Perpiñá-Clérigues Carla , Mellado Susana , Català-Senent José F. , Ibáñez Francesc , Costa Pilar , Marcos Miguel , Guerri Consuelo , García-García Francisco , Pascual Maria 
Published: March 2023

Abstract
Background:Lipids represent essential components of extracellular vesicles (EVs), playing structural and regulatory functions during EV biogenesis, release, targeting, and cell uptake. Importantly, lipidic dysregulation has been linked to several disorders, including metabolic syndrome, inflammation, and neurological dysfunction. Our recent results demonstrated the involvement of plasma EV microRNAs as possible amplifiers and biomarkers of neuroinflammation and brain damage induced by ethanol intoxication during adolescence. Considering the possible role of plasma EV lipids as regulatory molecules and biomarkers, we evaluated how acute ethanol intoxication differentially affected the lipid composition of plasma EVs in male and female adolescents and explored the participation of the immune response.
Methods:Plasma EVs were extracted from humans and wild-type (WT) and Toll-like receptor 4 deficient (TLR4-KO) mice. Preprocessing and exploratory analyses were conducted after the extraction of EV lipids and data acquisition by mass spectrometry. Comparisons between ethanol-intoxicated and control human female and male individuals and ethanol-treated and untreated WT and TLR4-KO female and male mice were used to analyze the differential abundance of lipids. Annotation of lipids into their corresponding classes and a lipid set enrichment analysis were carried out to evaluate biological functions.
Results: We demonstrated, for the first time, that acute ethanol intoxication induced a higher enrichment of distinct plasma EV lipid species in human female adolescents than in males. We observed a higher content of the PA, LPC, unsaturated FA, and FAHFA lipid classes in females, whereas males showed enrichment in PI. These lipid classes participate in the formation, release, and uptake of EVs and the activation of the immune response. Moreover, we observed changes in EV lipid composition between ethanol-treated WT and TLR4-KO mice (e.g., enrichment of Glycerphosphoinositols in ethanol-treated WT males), and the sex-based differences in lipid abundance are more notable in WT mice than in TLR4-KO mice. All data and results generated have been made openly available on a web-based platform (http://bioinfo.cipf.es/sal).
Conclusions: Our results suggest that binge ethanol drinking in human female adolescents leads to a higher content of plasma EV lipid species associated with EV biogenesis and the propagation of neuroinflammatory responses than in males. In addition, we discovered greater differences in lipid abundance between sexes in WT mice compared to TLR4-KO mice. Our findings also support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation during adolescence.
WITHDRAWN: Inter-rater Reliability of Risk of Bias Tools for Non-Randomized Studies
Authors: Kalaycioglu Isabel , Rioux Bastien , Briard Joel Neves , Nehme Ahmad , Touma Lahoud , Dansereau Benedicte , Veilleux Ariane , Keezer Mark 
Published: March 2023

Abstract
PURPOSE
There is currently no recommended risk of bias (ROB) tools to assess the internal validity of systematic reviews involving exposure or frequency studies. We aimed to first identify and secondly compare the inter-rater reliability (IRR) of six commonly used tools for frequency (Loney scale, Gyorkos checklist, American Academy of Neurology [AAN] tool) and exposure (Newcastle-Ottawa scale, SIGN50 checklist, AAN tool) studies in neurology.
METHODS
Six raters independently assessed the ROB of 30 frequency and 30 exposure studies using the 3 respective ROB tools. Articles were rated on a 3-level summary measure of ROB (low, intermediate, or high). We calculated an intraclass correlation coefficient (ICC) for each tool and category of ROB tool. We compared the IRR between ROB tools and tool type by inspection of overlapping ICC 95% CIs and by comparing their coefficients after transformation to Fisher Z values. We assessed criterion validity of the AAN ROB tools by calculating an ICC for each rater in comparison with the original ratings from the AAN.
RESULTS
All individual ROB tools had at least a substantial IRR (ICC point estimate = 0.61–0.80). The IRR was almost perfect (ICC point estimate > 0.80) for the AAN frequency tool and the SIGN50 checklist. All tools were comparable in IRR, except for the AAN frequency tool which had a significantly higher ICC than the Gyorkos checklist (p = 0.021) and trended towards a higher ICC when compared to the Loney scale (p = 0.085). When examined by category of ROB tool, scales and checklists had a substantial IRR, whereas the AAN tools had an almost perfect IRR. For the AAN ROB tools, the average agreement between our raters and the original AAN ratings was moderate.
CONCLUSION
All tools had substantial IRR except for the AAN frequency tool and the SIGN50 checklist, which both had an almost perfect IRR. The AAN ROB tools were the only category of ROB tool to demonstrate an almost perfect IRR. This category of ROB tool had fewer and more simple criteria. Overall, parsimonious tools with clear instructions, such as those from the AAN, may provide more reliable ROB assessments.
Lomitapide: A Medication Use Evaluation &amp; a Formulary Perspective
Authors: Esba Laila Carolina Abu , Alharbi Hani 
Published: March 2023

Abstract

Background and aims: Lomitapide is approved for lowering LDL-C in homozygous familial hypercholesterolemia, a rare genetic disorder. The evidence on its safety and efficacy from a small clinical trial requires further validation on effectiveness and safety in real-world. The aim of this study was to utilize institutional data on effectiveness and safety of lomitapide; to assist in formulating a perspective on adding it to the formulary.
Methods: This was a retrospective review of patients that were actively being prescribed lomitapide at King Abdulaziz Medical City, Riyadh, Saudi Arabia from 2019 to 2022. Data collection included: demographics, confirmed gene mutation results, duration of lomitapide therapy, baseline, on treatment, and last LDL-C, percent reduction in LDL-C after 1-3 months of therapy (whichever was first available), other LDL-C lowering therapies used, liver function tests, adverse effects and compliance.
Results: Eight adult patients were included in the review, the mean age was 25.5 years old, ~75% were female, and the duration of treatment with lomitapide ranged from 9 months to 3 years. None of the patients were on continuous LDL-apheresis. The mean baseline LDL-C at presentation to our facility was 17.2 mmol/L (range 11.78- 21.97 mmol/L), the mean percent drop in LDL-C with lomitapide was 34.1% (range 0- 87%), gastrointestinal disturbances were documented in 50% of the patients, and no cases of severe liver toxicities or increase in liver enzymes were seen.
Conclusions: In our cohort of adult patients, lomitapide showed an overall modest reduction in LDL-C, with no cases of increase in liver enzymes and documented intolerance indicating that most patients were likely non-compliant. This review revealed important considerations when reimbursing expensive medications for rare diseases. Real-world evidence in real-time can support health care systems in price negotiations and reaching mutual agreements that eventually can improve patient access to care.
Effect of Balint Group on Burnout and Self-efficacy of Nurse Leaders in China: A Randomised Controlled Trial
Authors: Shan Qu , Leonhart Rainer , Zhijuan Xie , Minjie Zheng , Xinxin Shi , Bai Xinzhu , Xiangyan Kong , Fritzsche Kurt 
Published: March 2023

Abstract
Background: Burnout is common among nurses and is related to negative outcomes of medical care. This study aimed to explore the effectiveness of Balint group activities in burnout reduction among nurse leaders in a Chinese hospital.
Methods: This was a randomised controlled trial with a pre- and post-test. A total of 80 nurse leaders were randomly assigned to either a Balint group (n=40) or a non-Balint group (n=40). Participants in the Balint group completed Balint training for a period of three months. Participants in both groups completed the Maslach Burnout Inventory-Human Services Survey (MBI) and the General Self-Efficacy Scale (GSES) at the beginning and end of the study. Balint group members also completed the Group Climate Questionnaire-Short Form.
Results: In the Balint group, 33 participants attended all sessions of the Balint intervention, and in the non-Balint group, all 40 participants completed the study. Analysis of variance with repeated measures demonstrated a statistically significant difference on the MBI subscale of personal accomplishment (F=9.598, p=0.003) between the Balint and non-Balint groups. However, there were no significant differences between the groups on the MBI subscales of emotional exhaustion (F=0.110, p=0.740) and depersonalization (F=0.75, p=0.387), and the GSES (F=0.709, p=0.403).
Conclusions: Balint group helped reduce burnout among nurse leaders, especially to personal accomplishment.
Ionic Liquid and Glucosamine Modified Magnetic Nanoparticles for Stabilization of Nano sized Palladium and Study of its Catalytic Activity
Authors: Zareh Fatemeh , Gholinejad Mohammad , Sheibani Hassan , Sansano José Miguel 
Published: March 2023

Abstract
A magnetic nanocomposite comprising imidazolium ionic liquid and glucosamine is successfully synthesized and used for stabilization of Pd nanoparticles. This new material, Fe3O4@SiO2@IL/GA-Pd, is characterized by scanning electron microscopy (SEM), transition electron microscopy (TEM), X-ray diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FT-IR), elemental maps, energy dispersive X-Ray analysis (EDX) and vibrating-sample magnetometer (VSM). Prepared nanocomposite is applied as a catalyst in reduction of nitroaromatic compounds to desired amines at room temperature as well as in reductive degradation of organic dyes such as methylene Blue (MB), methyl orange (MO) and rhodamine B (RhB). Results show that the catalyst has excellent catalytic activity in the already mentioned reactions and easily recycled and reused for 11 consecutive cycle without its changing catalytic activity. TEM, XRD and VSM are confirmed the stability of the reused catalyst.
Educational intervention for the promote behaviors related to oral health: a randomized trial protocol
Authors: Marashi Seyedeh Zahra , Hidarnia Alireza , Kazemi Seyedeh Somayeh , Zarei Fatemeh 
Published: March 2023

Abstract
Background: Oral health is an essential part of the overall health in infants, children, and adolescents; because oral diseases have effect on growth performance and quality of life. Given that adolescence is associated with many changes, including physical, sexual and psychosocial changes, and on the other hand, nowadays; many adolescents use mobile applications to monitor their lifestyle behaviors and improve their health. Therefore, the present study will be conducted with the aim of the effect of educational intervention based on self-efficacy theory on promoting adolescent oral health behaviors through the mobile application.
Methods: This is a randomized controlled trial that will be done in two steps. The first stage is related to a descriptive-analytical study; at this stage, determination the current status and educational need assessment of behaviors related to oral health and will be reviewed eligible individuals. The second stage is an experimental study, which is based on the results of a descriptive-analytical study and intervention design. At this stage, eligible adolescents are divided into two groups of intervention and control based on randomized allocation. Then the interventions will be implemented by using of educational strategies based on the self-efficacy theory. Evaluations will be performed with a standard questionnaire of self-efficacy and behaviors related to oral health (knowledge, attitude, behavior), at three points of time (1) Before intervention, (2) one month and (3) three months after the intervention.
Discussion: Adolescents who are in the early stages of permanent teeth; and this unfavorable condition of the mouth and teeth can have negative effects on the longevity of permanent teeth. This study is an attempt to investigate the impact of interventions in promotion behaviors related to oral health of adolescents through the mobile application.
Trial Registration: Iranian Registry of Clinical Trial (IRCT) IRCT20200120046204N1. Registered on 24 September 2022 Ethics code: IR.MODARES.REC.1401.125
Are Dogs Suitable Proxies for Humans in Archaeological Isotopic Dietary Assessments? Bayesian Analyses of Bone Collagen Stable Isotope Ratios from Ancestral Iroquoian Sites
Authors: Hart John P. 
Published: March 2023

Abstract
Under the archaeological canine surrogacy approach (CSA) it is assumed that because dogs were reliant on humans for food, they had similar diets to the people with whom they lived. As a result, the stable isotopes of their tissues (bone collagen and apatite, tooth enamel and dentine collagen) will be close to the humans with whom they cohabited. Therefore, in the absence of human tissue, dog tissue isotopes can be used to reconstruct past human diets. Here d13C and d15N ratios on previously published dog and human bone collagen from fourteenth-seventeenth century AD ancestral Iroquoian village archaeological sites and ossuaries in southern Ontario are used with MixSIAR, a Bayesian dietary mixing model, to determine if dog stable isotope ratios are good proxies for human diets. The modeling results indicate that human and dogs had different diets. Human dietary protein came primarily from maize and high trophic level fish and dogs from maize, terrestrial animals, low trophic level fish, and human feces. This indicates that CSA is likely not a valid approach for the reconstruction of ancestral Iroquoian diets.
On graded fuzzy n-absorbing hyperideals in graded multiplicative hyperrings
Authors: Ghiasvand Peman , Al-Zoubi K. , Farzalipour F. 
Published: March 2023

Abstract
ABSTRACT. Let G be a group with identity e and R be a graded commutative multiplicative hyperring. In this article, we study the notion of graded fuzzy multiplicative hyperrings as a generalization of fuzzy multiplicative hyperrings. Also, we introduce and study the notion of graded fuzzy n-absorbing hyperideals of R as a generalization of fuzzy prime hyperideals. Many properties, examples and characterizations of graded fuzzy n-absorbing hyperideals of R are introduced. Moreover, among other results in this paper, we investigate graded fuzzy strongly n-absorbing hyperideals, graded fuzzy weakly completely n-absorbing hyperideals and graded fuzzy k-n-absorbing hyperideals. We obtain some basic properties and new results of this case of structures.
2010 Mathematics Subject Classification: 08A72, 20N20, 16W50
Facile fabrication of CuFe2O4 coated with Carbon Quantum Dots nanocomposite as an efficient heterogeneous catalyst toward the reduction of nitroaniline compounds for management of aquatic resources
Authors: Naghash-Hamed Samin , Arsalani Nasser , Mousavi Seyed Borhan 
Published: March 2023

Abstract
The main objective of the current study is to scrutinize the fabrication of facile carbon quantum dots (CQDs) of glucose along with CuFe2O4-CQD nanocomposite and its catalytic reduction towards 2-Nitroaniline (2-NA) and 4-Nitroaniline (4-NA). Considering this, glucose-CQDs and nanocomposite of CuFe2O4-CQD were synthesized via hydrothermal and co-precipitation methods, respectively. Afterward, the fabricated nanocomposite as a promising nanocatalyst was employed to catalyze the 2-NA and 4-NA as a model of toxic organic pollutants into the 1,2-diaminobenzene (1,2-DAB) and 1,4-diaminobenzene (1,4-DAB) with a reducing agent of sodium borohydride (NaBH4), sequentially. The developed CQDs and magnetic nanocomposite were analyzed using FT-IR, XRD, VSM, SEM, TEM, BET surface area, BJH pore volume, and UV-Vis techniques. The results explicated that the magnetically recyclable CuFe2O4-CQD catalyst demonstrated high activity (∼ 96.7 % conversion within 45 s, for 2-NA and ∼ 96.5 % conversion within 18 s, for 4-NA) and efficient recyclability (up to 5 Cycles). The pseudo-second-order apparent reaction constant rate (k2) of 2-NA and 4-NA reduction were 7.12×10-2 and 1.77×10-1, respectively. These findings reveal that the fabricated catalyst offers a new method for the simultaneous reduction of 2-nitroaniline as well as 4-nitroaniline simply for environmental safety purposes.
Controlling the Skyrmion Density and Size for Quantized Convolutional Neural Networks
Authors: LONE AIJAZ H. , Ganguly Arnab , Li Hanrui , El-Atab Nazek , Das Gobind , Fariborzi H. 
Published: March 2023

Abstract
Skyrmion devices show energy-efficient and high-integration data storage and computing capabilities. Herein, we present the results of experimental and micromagnetic investigations of the creation and stability of magnetic skyrmions in the Ta/IrMn/CoFeB/MgO thin-film system. We investigate the magnetic-field dependence of the skyrmion density and size using polar magneto-optic Kerr effect (MOKE) microscopy supported by a micromagnetic study. The evolution of the topological charge with time under a magnetic field is investigated, and the transformation dynamics are explained. Furthermore, considering the voltage control of these skyrmion devices, we evaluate the dependence of the skyrmion size and density on the Dzyaloshinskii–Moriya interaction and the magnetic anisotropy. We furthermore propose a skyrmion-based synaptic device based on the results of the MOKE and micromagnetic investigations. We demonstrate the spin-orbit torque–controlled discrete topological resistance states with high linearity and uniformity in the device. The discrete nature of the topological resistance (weights) makes it a candidate to realize hardware implementation of weight quantization in a quantized neural network (QNN). The neural network is trained and tested on the CIFAR-10 dataset, where the devices act as synapses to achieve a recognition accuracy of ~ 87%, which is comparable to the result of ideal software-based methods.
The impact of fast food marketing on brand preferences and fast food intake of youth aged 10-17 across six countries
Authors: Bagnato Mariangela , Roy-Gagnon Marie-Hélène , Vanderlee Lana , Hammond David , Kent Monique Potvin 
Published: March 2023

Abstract
Background
Consumption of fast food, which is associated with poor diet, weight gain and the development of noncommunicable diseases, is high amongst youth. Fast food marketing, a modifiable determinant of excess weight and obesity, affects youth’s food-related behaviours. This study aimed to examine the relationship between exposure to fast food marketing and the fast food brand preferences and intake amongst youth aged 10-17 across six countries.
Methods
Data from 9,695 youth respondents living in Australia, Canada, Chile, Mexico, the United Kingdom (UK) and the United States (US) were analyzed from the 2019 International Food Policy Youth Study. Survey measures assessed exposure to fast food marketing and brand-specific marketing, and preference for these brands and fast food intake. Regression models adjusted for age, sex, income adequacy and ethnicity were used to examine the associations.
Results
Exposure to fast food marketing was positively associated with brand preferences and intake consistently across most countries. Overall, preference for McDonald’s (OR:1.97; CI:1.52, 2.56), KFC (OR:1.61; CI:1.24, 2.09) and Subway (OR:1.73; CI:1.34, 2.24) were highest when exposed to general fast food marketing ≥2x/week compared to never. Preference for McDonald’s (OR:2.32; CI:1.92, 2.79), KFC (OR:2.28; CI:1.95, 2.68) and Subway (OR:2.75; CI:2.32, 3.27) were also higher when exposed to marketing for each brand compared to not. Fast food intake was highest in Chile (IRR:1.90; CI:1.45, 2.48), the UK (IRR:1.40; CI:1.20, 1.63), Canada (IRR:1.32; CI:1.19, 1.48), Mexico (IRR:1.26; CI:1.05, 1.53) and the US (IRR:1.21; CI:1.05, 1.41) when exposed to general fast food marketing ≥2x/week compared to never and was higher
across most countries when exposed to brand-specific marketing compared to not. Respondents classified as ethnic minorities were more likely to report consuming fast food than ethnic majorities, and females were less likely to report consuming fast food than males.
Conclusions
Exposure to fast food marketing is consistently and positively associated with brand preferences and fast food intake in all six countries. Our results highlight the need for strict government regulation to reduce exposure of unhealthy food marketing to youth in all six countries.
Maternal Mental Health and Breastfeeding Support in Tertiary Hospital Nurseries in Nigeria
Authors: Alao Michael Abel , Ibrahim Olayinka Rasheed , Yekini Sakiru Abiodun , Sotimehin Sikirat Adetoun , Diala Udochukwu Michael , Briggs Datonye Christopher , Musa Aishatu Zaidu , Imam Zainab Oluwatosin , Famutimi Esther oluwatoyin , Idris Adedeji Abiodun , Ayuk Adaeze C. , Iloh Kenechukwu Kosisochukwu , Odimegwu Chioma Laura , Adeyemi Ayomide Toluwanimi , Medupin Patricia F , Adeniyi Yetunde C. , Nnamani Kenechi Ogbodo , Tongo Olukemi Oluwatoyin 
Published: March 2023

Abstract

Background
The postpartum period is associated with an increased risk of maternal mental disorders. The combined effect of having the mother's infant admitted to a tertiary hospital in a low-resource setting and the need to exclusively breastfeed the infant may exaggerate this risk. This study aimed to determine the breastfeeding support provided to mothers whose infants were hospitalised in Nigerian tertiary hospital nurseries and the prevalence of common mental health disorders among this population.
Methods
This was a national cross-sectional study involving mothers of hospitalised infants from eleven Nigerian tertiary hospitals between May and August 2022. To assess mothers' mental health and breastfeeding support, we utilised the WHO self-reporting Questionnaire 20 and an adapted WHO/UNICEF ten-step breastfeeding support package.
Results
Of the 1,120 mothers recruited from neonatal nurseries in the six geopolitical zones in Nigeria, only 895 had a complete dataset for analysis. The mean age of the mothers was 29.9 ±6.2; with 54.7% belonging to the low-socioeconomic class. Most of the mothers (835, 93.3%) received antenatal care, and 591: 66.0% were delivered at term. Overall, less than half (427; 47.7%) of the mother received optimal breastfeeding support. One in every four, 216; 24.0% of nursing mothers (95% CI: 21.235 to 26.937%) had common mental disorders (CMD). History of mental health disorders was reported in 41; 4.6% of the nursing mothers. Overall, the lowest performing areas of breastfeeding support were family-centred care (198, 22.1%), practical skill demonstration in the ward (n=279, 31.2%), and antenatal clinics (n=294, 32.8%). CMDs were statistically significantly associated with the healthcare provider's practical breastfeeding skill demonstration and the provision of storage facilities for breastmilkand family-centered-care. Across Nigeria's six geopolitical zones, there was an inverse relationship between optimal breastfeeding support and the proportion of mothers with CMDs. The northern zone provided better breastfeeding support and had fewer CMDs than the southern region of the country.
Conclusion
Common mental disorders are prevalent among nursing mothers in Nigerian tertiary hospital nurseries, and they are inversely related to breastfeeding support. Urgently required in tertiary hospitals for improved and sustainable breastfeeding practices are a focus on family-centred care and enhanced health workers’ practical breastfeeding support skills.