bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microglial Expression of the Wnt Signaling ModulatorDKK2Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models
Authors: Aghaizu Nozie D. , Jolly Sarah , Samra Satinder K. , Kalmar Bernadett , Craessaerts Katleen , Greensmith Linda , Salinas Patricia C. , De Strooper Bart , Whiting Paul J. 
Published: January 2023

AbstractWnt signaling is crucial for synapse and cognitive function. Indeed, deficient Wnt signaling is causally related to increased expression ofDKK1,an endogenous negative Wnt regulator, and synapse loss, both of which likely contribute to cognitive decline in Alzheimer’s disease (AD). Increasingly, AD research efforts have probed the neuroinflammatory role of microglia, the resident immune cells of the CNS, which have furthermore been shown to be modulated by Wnt signaling. TheDKK1homologDKK2has been previously identified as an activated response and/or disease-associated microglia (DAM/ARM) gene in a mouse model of AD. Here, we performed a detailed analysis ofDKK2in mouse models of neurodegeneration, and in human AD brain. InAPP/PS1andAPPNL-G-FAD mouse model brains as well as inSOD1G93AALS mouse model spinal cords, but not in control littermates, we demonstrated significant microgliosis and microglialDkk2mRNA upregulation in a disease-stage-dependent manner. In the AD models, these DAM/ARMDkk2+microglia preferentially accumulated close to βAmyloid plaques. Furthermore, recombinant DKK2 treatment of rat hippocampal primary neurons blocked WNT7a-induced dendritic spine and synapse formation, indicative of an anti-synaptic effect similar to that of DKK1. In stark contrast, no such microglialDKK2upregulation was detected in the postmortem human frontal cortex from individuals diagnosed with AD or pathologic aging. In summary, the difference in microglial expression of the DAM/ARM geneDKK2between mouse models and human AD brain highlights the increasingly recognized limitations of using mouse models to recapitulate facets of human neurodegenerative disease.
Deeper Than You Think: Partisanship-Dependent Brain Responses in Early Sensory and Motor Brain Regions
Authors: Katabi Noa , Simon Hadas , Yakim Sharon , Ravreby Inbal , Ohad Tal , Yeshurun Yaara 
Published: January 2023

Recent political polarization has illustrated how individuals with opposing political views often experience ongoing events in markedly different ways. In this study, we explored the neural mechanisms underpinning this phenomenon. We conducted fMRI scanning of 34 right- and left-wing participants (45% females) watching political videos (e.g., campaign ads and political speeches) just before the elections in Israel. As expected, we observed significant differences between left- and right-wing participants in their interpretation of the videos' content. Furthermore, neuroimaging results revealed partisanship-dependent differences in activation and synchronization in higher-order regions. Surprisingly, such differences were also revealed in early sensory, motor, and somatosensory regions. We found that the political content synchronized the responses of primary visual and auditory cortices in a partisanship-dependent manner. Moreover, right-wing (and not left-wing) individuals' sensorimotor cortex was involved in processing right-wing (and not left-wing) political content. These differences were pronounced to the extent that we could predict political orientation from the early brain-response alone. Importantly, no such differences were found with respect to neutral content. Therefore, these results uncover more fundamental neural mechanisms underlying processes of political polarization.SIGNIFICANCE STATEMENTThe political sphere has become highly polarized in recent years. Would it be possible to identify the neural mechanisms underpinning such processes? In our study, left- and right-wing participants were scanned in fMRI while watching political video clips just before the elections in Israel. We found that political content was potent in synchronizing the brain responses of individuals holding similar views. This was far more pronounced in individuals holding right-wing views. Moreover, partisan-dependent differences in neural responses were identified already in early sensory, somatosensory, and motor regions, and only for political content. These results suggest that individuals' political views shape their neural responses at a very basic level.
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis
Authors: Zeng Zhan‐Cheng , Pan Qi , Sun Yu‐Meng , Huang Heng‐Jing , Chen Xiao‐Tong , Chen Tian‐Qi , He Bo , Ye Hua , Zhu Shun‐Xin , Pu Ke‐Jia , Fang Ke , Huang Wei , Chen Yue‐Qin , Wang Wen‐Tao 
Published: January 2023

AbstractN6‐Methyladenosine (m6A) is an important RNA modification catalyzed by methyltransferase‐like 3 (METTL3) and METTL14. m6A homeostasis mediated by the methyltransferase (MTase) complex plays key roles in various biological processes. However, the mechanism underlying METTL14 protein stability and its role in m6A homeostasis remain elusive. Here, we show that METTL14 stability is regulated by the competitive interaction of METTL3 with the E3 ligase STUB1. STUB1 directly interacts with METTL14 to mediate its ubiquitination at lysine residues K148, K156, and K162 for subsequent degradation, resulting in a significant decrease in total m6A levels. The amino acid regions 450–454 and 464–480 of METTL3 are essential to promote METTL14 stabilization. Changes in STUB1 expression affect METTL14 protein levels, m6A modification and tumorigenesis. Collectively, our findings uncover an ubiquitination mechanism controlling METTL14 protein levels to fine‐tune m6A homeostasis. Finally, we present evidence that modulating STUB1 expression to degrade METTL14 could represent a promising therapeutic strategy against cancer.
The Antinomy of Philology (an Approach by Jules David)
Authors: Eloeva Fatima 
Published: January 2023

The paper presents an attempt to reconstruct the original method of mastering the Modern Greek, created for classical philologists by a talented researcher and classical philologist Jules David. Jules David (Charles-Louis-Jules David, 1783–1854) was the son of Jacques-Louis David (1748–1825), apparently the most successful and well paid artist in the entire history of France, the creator of neoclassicism. We will try to show that his scientific conception presents an interesting attempt to establish a connection between the ancient and modern state of the Greek continuum. Jules David’s linguo-didactic approach is innovative and unexpected – while discussing the standard of the Greek language, he managed to combine elegantly the descriptive and prescriptive aspects of the language analysis. His main work, the Comparative description of the Ancient Greek and Demotic Languages (Συνοπτικός παραλληλισμός της ελληνικής και γραικικής απλοελληνικής γλώσσης) is a fascinating attempt to establish the parallels of the Ancient Greek and Modern Greek languages. In addition Jules David set himself another and not trivial task indeed – to make classical philologists, dealing with the Ancient Greek, feel that they are dealing with a living language, and not with a dead scheme. We believe that this strategy of David, due to its originality, has not been fully understood by researchers and can be compared with the views of another outstanding neo-Hellenist and philosopher Nikolaj Bakhtin, the brother of philosopher Mikhail Bakhtin (1884–1950).
First-Principles Investigation of Concentration Effects on the Electronic and Vibrational Properties of a Boron Aluminum Phosphide Alloy with Wurtzoid Nanostructure
Authors: Fayyadh H.A. 
Published: January 2023

The vibrational and electronic properties of the binary wurtzoids Al7P7 and B7P7 and the ternary one BxAl7-xP7 have been investigated by the use of the approximation of the Density Functional Theory (DFT). By varying the concentration x, we carried out the calculations and various simulations of the bond lengths, energy gap, density of states, force constants, reduced masses, and infrared and Raman spectra. The geometric nanostructure of BxAl7-xP7 wurtzoid has been analyzed using the Gauss view 05 program. As the concentration of B increases, the energy gap widens, indicating that the estimations are consistent with the experimental longitudinal optical measurements. We utilize the theoretical ab initio technique to mimic the properties and nanostructures of BxAl7-xP7 wurtzoid using DFT B3LYP with the 6-311-G** basis sets and the GGA calculations with all electrons.
Aplicativos para autogestão do diabetes tipo 1 em usuários de sistema de infusão contínua de insulina
Authors: Albuquerque Brandão Maria Girlane Sousa , Ximenes Maria Aline Moreira , Teixeira Carla Regina de Sousa , Veras Vivian Saraiva 
Published: January 2023

Objetivo: Identificar e descrever as características dos aplicativos móveis para autogestão do diabetes mellitus tipo 1 em usuários de sistema de infusão contínua de insulina.
Método: Revisão integrativa, com buscas efetuadas no mês de junho de 2020, a partir dos artigos publicados PUBMED, CINAHL, Cochrane Library, Web of Science e Scopus. Considerou-se como critério de elegibilidade estudos que abordavam sobre aplicativos móveis para autogestão do DM1 em usuários de Sistema de Infusão Contínua de Insulina, sem restrição temporal. Foram excluídos apenas estudos indisponíveis.
Resultados: Após a análise de duas revisoras independentes foram incluídos na análise final 14 estudos e identificados 11 aplicativos móveis para smartphones que podem auxiliar no autogerenciamento do DM1, nomeados como iDECIDE, Sugar Sleuth, VoiceDiab, Blip, GoCARB, Nightscout, Gerenciamento Inteligente de Diabetes, Calculadora móvel de troca de Alimentos, Insulin Pump, DiaMob e Diário Interativo sobre Diabetes.
Conclusão: Os aplicativos móveis foram desenvolvidos para promover mudanças de comportamento e ajustes no tratamento de maneira positiva, tanto em resultados clínicos quanto na qualidade de vida e autogestão do diabetes em pessoas com DM1. Aplicativos móveis para smartphones podem auxiliar no autogerenciamento do DM1, por possibilitar auxílio na decisão de aplicação de insulina, controle glicêmico, análise na necessidade de insulina nas refeições, gestão alimentar, cálculo dos componentes alimentares nas refeições, monitoramento contínuo da glicose e cálculo automático de bolus de carboidratos e insulina.
Práticas de estudo na comunidade acadêmico-digital
Authors: Marigo Adriana Fernandes Coimbra , Reyes Claudia , Bozzini Isabela Custódio Talora 
Published: January 2023

Este texto relata a experiência de três professoras universitárias a partir de um projeto apresentado ao Programa de Assistência Estudantil (PAE), elaborado com o intuito de introduzir os estudantes no ensino remoto emergencial no contexto da pandemia da COVID-19. O curso proposto “Práticas de Estudo na Comunidade Acadêmico-Virtual”, teoricamente fundamentado na aprendizagem dialógica, trouxe elementos essenciais para o bom desempenho dos estudantes, explorando diferentes linguagens acadêmicas muito utilizadas nos cursos de graduação: leitura crítica, escrita de resumos e resenhas, elaboração e gravação de seminários. Os estudantes inscritos eram de diferentes cursos de graduação da universidade e estavam em semestres iniciais em sua maioria. Entendemos que a oferta do curso, baseado em evidências científicas de máximas aprendizagens foi fundamental para o acompanhamento dos estudantes em seus cursos de graduação e para nossa formação continuada, oportunizando a vivência da co-docência. Nesse sentido, pudemos evidenciar que a diversidade das docentes (de formação, atuação profissional e tempo na universidade) foram determinantes para que todos os objetivos fossem alcançados.
Ações extensionistas em uma disciplina de educação ambiental
Authors: Souza Jana Magaly Tesserolli de , Morais Josmaria Lopes de 
Published: January 2023

Introdução/Objetivo: Este trabalho foi escrito com o objetivo de promover reflexão sobre uma experiência de curricularização da extensão em uma disciplina de graduação. A disciplina de Educação Ambiental foi ministrada no formato remoto durante a pandemia da COVID-19, em uma universidade pública do sul do Brasil. Metodologia: A pesquisa com abordagem qualitativa de natureza exploratória apresenta oito ações extensionistas de sensibilização ambiental idealizadas e implementadas pelos estudantes de diferentes cursos de graduação durante dois semestres letivos. Neste estudo são destacados dois desafios: o primeiro, trabalhar de forma remota, e o segundo, ministrar uma disciplina com o compromisso de realização de ações de extensão pelos graduandos organizados em equipes. Resultados: Os resultados revelaram que, além do protagonismo dos estudantes, as ações de extensão contribuíram para a divulgação e sensibilização quanto a temáticas de interesse ambiental. Conclusão: Entende-se que uma disciplina de caráter extensionista, embora exija uma dedicação maior tanto de professores quanto de graduandos, se configura como uma possibilidade viável de inserir a extensão universitária no currículo dos cursos de graduação, de promover a formação integral dos estudantes e de contribuir para a transformação da sociedade.
Effects of cane- and spur-retained node numbers on the pre-flowering vegetative growth of cane-pruned Sauvignon blanc
Authors: Epee Paul T. M. , Schelezki Olaf , Trought Michael C. T. , Werner Armin , Hofmann Rainer W. , Almond Peter , Charters Stuart , Parker Amber 
Published: January 2023

In established vineyards, node number retention at winter pruning is the first step to achieving and maintaining vine balance. Balanced vines exhibit timely and quasi-uniform 100 percent budburst. To understand how vine capacity and balance are expressed before flowering, mature Sauvignon blanc vines were pruned according to a 5 [total node numbers on canes: 10, 20, 30, 40, 50] x 3 [total node numbers on spurs: 1, 2, 3] factorial design in one site, and in two other sites according to a 5 [total node numbers on canes: 10, 20, 30, 40, 50] x 2 [total node numbers on spurs: 1, 2] factorial design. Two spurs of one, two or three nodes each were retained on either side of the vine. The number of canes laid down per vine was one, two, three and four canes each of 10 nodes for the 10-, 20-, 30- and 40-node treatments, and four canes averaging 12.5 nodes for the 50-node treatment. The budburst percentage was calculated on the whole vine, canes, and spurs. Blind nodes, count shoots, non-count shoots and double shoots were counted and mapped along canes and spurs. Many non-count shoots were measured on the vine head of 10-node vines (29.5 ± 3.0 shoots, p < 0.001), compared to 50-node vines (2.8 ± 1.9 shoots, p < 0.001). 50-node vines had an overall budburst of 100 %, despite having the highest number of blind nodes (7.6 ± 0.3 nodes, p < 0.001). These were mainly located at the canes’ proximal sections relative to the vine head and were likely caused by correlative inhibition and primary bud necrosis. Cane budburst provided a more accurate assessment of the vine response to node loading than vine budburst. The number of double shoots was not associated with the vine node load, as they appeared on both low-node and high-node vines. Three-node spurs developed more blind nodes than one-node and two-node spurs (p < 0.001). Based on the findings of this research, we recommend a composite metric (cane percent budburst, cane blind node count and head shoot count) to assess vine capacity and balance between budburst and flowering, and the practice of retaining one- or two-node spurs at cane pruning is also justified.
Exploring Sociolects in Audiovisual Texts. A New Concept?
Authors: Martínez Sierra Juan José 
Published: January 2023

This article is based on a consideration of the audiovisual text as a system in which different signifying codes converge, giving it a multimodal nature. Studies on the nature of the audiovisual text have addressed a multitude of aspects to date, although there are still concepts to be explained within the audiovisual paradigm. One such aspect has to do with varieties of language, specifically with the notion of sociolect. After a review of the literature, fragments of television sitcoms will be analysed to observe the possible audiovisual nature of the given sociolect. Specifically, it will be illustrated how language levels, slang, and scientific-technical language deal with audiovisual humour. The idea will be fostered that in this type of text, sociolects go beyond the linguistic scope and connect with the aural and visual dimensions. Accordingly, phenomena such as humour can be constructed thanks to elements that surpass a purely linguistic conception of sociolects.
Keywords: Audiovisual translation, Signifying codes, Language variation, Sociolects
Remote Interpreting in Spain after the Irruption of COVID-19: A Mapping Exercise
Authors: Lázaro Gutiérrez Raquel , Nevado Llopis Almudena 
Published: January 2023

Remote interpreting, particularly telephone interpreting, was implemented in Spain less than 20 years ago and, since then, it has become increasingly common. Its use has even increased during the last months, due to COVID-19 circumstances and the subsequent growth of telecommuting. This paper aims at mapping remote interpreting services in Spain. With that purpose, structured qualitative interviews were conducted with representatives of the six main Spanish companies offering these services. The results show a diffusion of telephone interpreting across the country and an incipient presence of video-link interpreting. Nevertheless, more attention to quality performance and working conditions should be paid.
Keywords: Telephone interpreting, Video-link interpreting, Mapping, Qualitative interviews, Spain
Finding ethics in and out of codes: ethical dilemmas faced by healthcare interpreting student interns
Authors: Álvaro Aranda Cristina 
Published: January 2023

Establishing a code of ethics is a requirement an occupation must meet to become a full-fledged profession. In healthcare interpreting, several professional associations have published their own codes. Students are introduced to these codes in the classroom, but when they access the profession they often face ethical dilemmas that may overlap with their professional obligations. This paper explores a series of ethical dilemmas faced by students that first encounter the workplace as part of an internship programme. Drawing on participant observation and post-encounter interviews, we identify ethical dilemmas, describe the interns’ behaviour, and illustrate the rationale behind their choices. This allows us to isolate factors that hinder participants from strict adherence to codes of ethics (i.e., the theory-practice gap, contextual restrictions, and human emotion). In the light of results obtained, we encourage trainers and interpreters to develop critical ethical thinking in different healthcare scenarios to facilitate assessing the consequences of (not) following a code of ethics.
Keywords: Healthcare interpreting, Ethical dilemmas, Code of ethics, Student interns, Training
Are we teaching what they need? Going beyond employability in Translation Studies
Authors: Sánchez Ayuso Pablo , Haro Soler María del Mar , García de Quesada Mercedes 
Published: January 2023

As lecturers and researchers in translation and interpreting, we are aware of the need to design curricula so that students are well equipped, and able to respond to the requirements of modern society. In the world today, there is an evident gap between what is actually taught in higher education and what should be taught to meet student needs. Even though various studies have already focused on the impact of constructs, such as self-regulation, empathy, or creativity, on performance quality, there is still a long way to go. In order to bridge this gap and highlight the role of the university as a transformational agent, our study uses LifeComp, the European framework for the personal, social, and learning to learn key competence. The objective of this research was firstly to discover the transversal competences that are most highly valued by employers in the language industry sector; and secondly, to identify the competences that need more attention in curricula. For this purpose, a questionnaire-based study was designed and administered to translation companies based in Spain. The results obtained indicate that these competences are necessary to foster employability as well as real wealth creation in a lifelong learning context. This study is part of a broader project within the LifeComp framework, in which a competence-based psycho-educational intervention was designed and is now integrated in the translation and interpreting degree programme at the University of Granada (Spain).
Keywords: Competence-based learning, LifeComp, Curriculum design, Higher education, Employability
Por uma cartografia do (r)existir cotidiano: o viver e as práticas espaciais da comunidade LGBTQIA+ no município de Pelotas
Authors: Alves Pedro , Siqueira Gabriela , Duarte Tiaraju 
Published: January 2023

O presente trabalho discute a construção de uma cartografia social da resistência LGBTQIA+ no espaço urbano do município de Pelotas. A análise é fruto da aproximação de duas pesquisas acadêmicas, sendo a primeira um trabalho de conclusão de curso de licenciatura em Geografia intitulado “As múltiplas territorialidades do medo e violência LGBTQIA+ na cidade de Pelotas: Corpos em processo de exclusão” e o segunda um projeto desenvolvido junto ao grupo de pesquisa “Margens: grupos em processo de exclusão e suas formas de habitar Pelotas/RS” que investiga como os atores pertencentes a comunidade LGBTQIA+ fazem-cidade e exercem seu direito à cidade. Frente a esta apresentação, o objetivo do presente artigo é identificar e cartografar as violências vivenciadas e as estratégias de enfrentamento desenvolvidas por quem é LGBTQIA+ na cidade de Pelotas, possibilitando neste sentido construir recursos didáticos voltados a conscientização desta situação. Em termos metodológicos, para elencar os pontos que seriam marcados em nossa cartografia recorremos, além das pesquisas mencionadas anteriormente, a revisão bibliográfica de trabalhos que abordam questões relacionadas a pessoas LGBTQIA+ no contexto de Pelotas e que tratassem de lugares ou acontecimentos que envolvessem formas de resistência na cidade. O caminho que seguimos para construção da cartografia teve grande influência dos entendimentos, expostos no artigo “Mapas, mapeamentos e a cartografia da realidade”, do geógrafo Seemann (2003). Além disso, para a realização do artigo foram utilizados vídeos, colagens digitais, colagens digitais em vídeos, narrativas, imagens, como formas de representar um cenário urbano que está em constante movimento, construído e reconstruído pela incessante relação entre periferias e centro (AGIER, 2015). Como base conceitual, partimos de um entendimento de resistência formulado por Michel Foucault (1988). Como resultados, podemos visualizar que a cartografia possibilitou identificar locais considerados seguros ou representativos (MAGNANI, 1993) que puderam inclusive se apresentar como formas táticas (CERTEAU, 2008) para fazer-cidade e exercer o direito à cidade (AGIER, 2015) - de pessoas LGBTQIA+. Estes elementos foram explorados por nós como forma de apresentar com diferentes linguagens e possibilidades, por meio da elaboração dos recursos didáticos, uma cidade de Pelotas que é feita de resistência, ainda que em suas dinâmicas existem inúmeras situações de violência. Assim, utilizamos da cartografia como forma de contar, como coloca Jörn Seemann (2003), que a cidade é feita por pessoas LGBTQIA+ através da articulação criativa de ações de lutas e táticas cotidianas para contornar estas violências.