bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-sectional field study comparing hippocampal subfields in patients with post-traumatic stress disorder, major depressive disorder, post-traumatic stress disorder with comorbid major depressive disorder, and adjustment disorder using routine clinical data
Authors: Knaust Thiemo , Siebler Matthias B. D. , Tarnogorski Dagmar , Skiberowski Philipp , Höllmer Helge , Moritz Christian , Schulz Holger 
Published: June 2023

BackgroundThe hippocampus is a central brain structure involved in stress processing. Previous studies have linked stress-related mental disorders, such as post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), with changes in hippocampus volume. As PTSD and MDD have similar symptoms, clinical diagnosis relies solely on patients reporting their cognitive and emotional experiences, leading to an interest in utilizing imaging-based data to improve accuracy. Our field study aimed to determine whether there are hippocampal subfield volume differences between stress-related mental disorders (PTSD, MDD, adjustment disorders, and AdjD) using routine clinical data from a military hospital.MethodsParticipants comprised soldiers (N = 185) with PTSD (n = 50), MDD (n = 70), PTSD with comorbid MDD (n = 38), and AdjD (n = 27). The hippocampus was segmented and volumetrized into subfields automatically using FreeSurfer. We used ANCOVA models with estimated total intracranial volume as a covariate to determine whether there were volume differences in the hippocampal subfields cornu ammonis 1 (CA1), cornu ammonis 2/3 (CA2/3), and dentate gyrus (DG) among patients with PTSD, MDD, PTSD with comorbid MDD, and AdjD. Furthermore, we added self-reported symptom duration and previous psychopharmacological and psychotherapy treatment as further covariates to examine whether there were associations with CA1, CA2/3, and DG.ResultsNo significant volume differences in hippocampal subfields between stress-related mental disorders were found. No significant associations were detected between symptom duration, psychopharmacological treatment, psychotherapy, and the hippocampal subfields.ConclusionHippocampal subfields may distinguish stress-related mental disorders; however, we did not observe any subfield differences. We provide several explanations for the non-results and thereby inform future field studies.
High prevalence of mental disorders: a population-based cross-sectional study in the city of Ilam, Iran
Authors: Kakaei Hojatollah , Maleki Farajolah , Biderafsh Azam , Valizadeh Reza , Mansournia Mohammad Ali , Pakzad Iraj , Pakzad Reza 
Published: June 2023

AimTo determine the age- and sex-standardized prevalence and risk factors of depression, anxiety, and stress symptoms in the city of Ilam.MethodIn this population-based cross-sectional study, 1,350 people were invited using a multi-stage stratified cluster random sampling method. Depression, anxiety, and stress symptoms were measured using the DASS-21 standard questionnaire. For data analysis, multiple ordinal logistic regression was used in Stata version 12 software. A significance level of 5% was considered.ResultsThe data of 1,431 people were analyzed. The age- and sex-standardized prevalence (95% CI) of severe depression, anxiety, and stress symptoms was 19.90% (17.64 to 22.16), 25.95% (23.48 to 28.43), and 15.75% (13.69 to 17.81), respectively. There was a positive association among depression symptoms with female sex (OR: 1.52; p &lt; 0.003), Kurdish ethnicity (OR: 2.15; p &lt; 0.004), low educational level (OR: 1.37; p &lt; 0.031), job losing history (OR: 1.64; p &lt; 0.001), mental disorders history (OR: 2.17; p &lt; 0.001), hopelessness for the future (OR: 5.38; p &lt; 0.001), and history of other diseases (OR: 1.67; p &lt; 0.001). There was a positive association among anxiety symptoms with female sex (OR: 1.72; p &lt; 0.001), job losing history (OR: 1.53; p &lt; 0.003), mental disorders history (OR: 2.11; p &lt; 0.001), hopelessness to future (OR: 3.33; p &lt; 0.001) and history of other diseases (OR: 1.97; p &lt; 0.001). Hopelessness for the future and a history of other diseases were the most effective variables for anxiety symptoms and stress symptoms.ConclusionA significant proportion of Ilam’s urban population suffers from mental disorders. Increasing people’s awareness, establishing counseling centers, and improving infrastructure should be considered by mental health policymakers who work in the province.
Antibiotic resistance of Streptococcus pneumoniae in Vietnamese children with severe pneumonia: a cross-sectional study
Authors: Tran-Quang Khai , Nguyen-Thi-Dieu Thuy , Tran-Do Hung , Pham-Hung Van , Nguyen-Vu Trung , Tran-Xuan Bach , Larsson Mattias , Duong-Quy Sy 
Published: June 2023

BackgroundStreptococcus pneumoniae is the most common bacterium that causes community-acquired pneumonia (CAP) in children. The rate of S. pneumoniae resistance to antibiotics is increasing, particularly in patients with severe CAP. Therefore, the level of antibiotic resistance of S. pneumoniae causing severe CAP in Vietnamese children requires regular monitoring.MethodsThis was a cross-sectional descriptive study. Nasopharyngeal aspiration specimens from children were cultured, isolated, and examined for S. pneumoniae. Bacterial strains were assessed for antimicrobial susceptibility, and the minimum inhibitory concentration (MIC) was determined.ResultsEighty-nine strains of S. pneumoniae were isolated from 239 children with severe CAP. The majority of isolates were completely non-susceptible to penicillin (1.1% intermediate, 98.9% resistant) and highly resistant to erythromycin (96.6%) and clarithromycin (88.8%); the rate of resistance to ceftriaxone was 16.9%, with the proportion of intermediate resistance at 46.0%; 100% of strains were susceptible to vancomycin and linezolid. For most antibiotics, MIC50 and MIC90 were equal to the resistance threshold according to the Clinical and Laboratory Standards Institute 2021; penicillin had an eight-fold increase in MIC90 (64 mg/L) and ceftriaxone had a 1.5-fold increase in MIC90 (6 mg/L).ConclusionStreptococcus pneumoniae isolates described in this study were resistant to many antibiotics. Penicillin should not be the first-line antibiotic of choice, and ceftriaxone at an enhanced dose should be used instead.
Using knowledge graphs to infer gene expression in plants
Authors: Thessen Anne E. , Cooper Laurel , Swetnam Tyson L. , Hegde Harshad , Reese Justin , Elser Justin , Jaiswal Pankaj 
Published: June 2023

IntroductionClimate change is already affecting ecosystems around the world and forcing us to adapt to meet societal needs. The speed with which climate change is progressing necessitates a massive scaling up of the number of species with understood genotype-environment-phenotype (G×E×P) dynamics in order to increase ecosystem and agriculture resilience. An important part of predicting phenotype is understanding the complex gene regulatory networks present in organisms. Previous work has demonstrated that knowledge about one species can be applied to another using ontologically-supported knowledge bases that exploit homologous structures and homologous genes. These types of structures that can apply knowledge about one species to another have the potential to enable the massive scaling up that is needed throughin silicoexperimentation.MethodsWe developed one such structure, a knowledge graph (KG) using information from Planteome and the EMBL-EBI Expression Atlas that connects gene expression, molecular interactions, functions, and pathways to homology-based gene annotations. Our preliminary analysis uses data from gene expression studies inArabidopsis thalianaandPopulus trichocarpaplants exposed to drought conditions.ResultsA graph query identified 16 pairs of homologous genes in these two taxa, some of which show opposite patterns of gene expression in response to drought. As expected, analysis of the upstream cis-regulatory region of these genes revealed that homologs with similar expression behavior had conserved cis-regulatory regions and potential interaction with similar trans-elements, unlike homologs that changed their expression in opposite ways.DiscussionThis suggests that even though the homologous pairs share common ancestry and functional roles, predicting expression and phenotype through homology inference needs careful consideration of integrating cis and trans-regulatory components in the curated and inferred knowledge graph.
Implementation and assessment of a novel non-clinical skills curriculum for urology residents
Authors: Sheetz Tyler , Diab Dinah , Scimeca Alicia , Bellows Fara , Sharp David S. , Lee Cheryl T. , Posid Tasha 
Published: June 2023

BackgroundUrology is an increasingly competitive specialty that procures a highly selected and clinically excellent cohort of residents. However, other training needs such as leadership and professional development go underrecognized despite an identified need for formal training in these areas. The aim of this study was to implement, evaluate, and pilot a non-clinical skills curriculum, a novel individualized professional development workshop series, at a single institution.MethodsEighteen urology residents (15/year, 3 graduates/year) participated in this study over the course of two academic years. A pre-curriculum needs assessment was completed by 15 residents in Year 1 for purposes of curriculum design. The curriculum itself was a series of 1-hour monthly workshops given by an expert speaker on topics relevant to healthcare delivery, leadership and career promotion across various contexts. Survey-based assessments tracked gains in subject knowledge and satisfaction via a pre-post test design.ResultsThe pre-curriculum needs assessment indicated that trainees desired additional instruction in non-clinical skills (ps&gt;0.1) and endorsed formal teaching to ensure success in their future careers (p&lt;0.001). Trainees reported pre- to post-curriculum gains across each individual learning topic (Mean=20%, p&lt;0.001) with an aggregate increase in subject knowledge of 17% for senior residents and 21% for junior residents (p&lt;0.001).ConclusionA non-clinical skills curriculum implemented as a pilot ‘Hidden Curriculum’ for urology trainees was feasible and resulted in significant gains in non-clinical subject knowledge. Workshops were highly rated and trainees reported high satisfaction with the curriculum.
Biomechanics of wheelchair turning manoeuvres: novel insights into wheelchair propulsion
Authors: Chaikhot Dhissanuvach , Taylor Matthew J. D. , de Vries W. H. K. , Hettinga Florentina J. 
Published: June 2023

IntroductionWheelchair turning biomechanics is an under researched area despite its obvious relevance to functional mobility of wheelchair users. Wheelchair turns might be linked to a higher risk of upper limb injuries due to the increased forces and torques potentially associated with asymmetric movement. Our aim was to obtain a better theoretical understanding of wheelchair turning by biomechanically analyzing turns compared to steady-state straightforward propulsion (SSSFP).MethodsTen able-bodied men received 12-min familiarization and 10 trials (in a random order) of SSSFP and multiple left and right turns around a rectangular course. A Smartwheel was mounted at the right wheel of a standard wheelchair to measure kinetic parameters during SSSFP and of the inner hand during right turns and the outer hand during left turns. A repeated measures ANOVA was used to detect differences across tasks.ResultsTwo strategies were identified: 3% demonstrated roll turns and 97% spin turns. Spin turns consisted of three phases: approach, turning and depart phase. The turning phase was accomplished by increasing peak force (72.9 ± 25.1 N vs. 43.38 ± 15.9 N in SSSFP) of the inner hand, while maintaining high push frequency of the outer hand (1.09 ± 0.20 push/s vs. 0.95 ± 0.13 push/s in SSSFP). Peak negative force and force impulse during the turning phase were much higher than SSSFP, 15.3 ± 15.7 and 4.5 ± 1.7 times higher, respectively.ConclusionThe spin turn strategy might carry an increased risk of upper limb injuries due to higher braking force and requires particular attention by rehabilitation professionals to preserve upper limb function of long-term wheelchair users.
Productive efficiency of beef cattle production in Botswana: a latent class stochastic meta-frontier analysis
Authors: Bahta Sirak , Temoso Omphile , Ng'ombe John N. , Rich Karl M. , Baker Derek , Kaitibie Simeon , Malope Patrick 
Published: June 2023

IntroductionEfficiency in food production is crucial for sustainable agriculture in developing countries. This paper contributes to the existing literature by presenting an innovative approach to modeling productive efficiency in beef cattle production. Treating farm performance across regions as unobserved heterogeneity, we determine technical efficiency of beef cattle production in Botswana. We aim to shed light on the factors influencing efficiency in this sector.MethodsThe study utilized block-level data from various annual agricultural surveys (2006–2014) covering 26 agricultural districts and six agro-ecological regions in Botswana. We employed a latent class stochastic frontier model complemented with the stochastic meta-frontier analysis.ResultsResults show that the best performing farming systems in terms of efficiency are districts with well-developed infrastructure and better access to output and input markets. In contrast, the farming systems that perform poorly consist of agricultural districts without access to livestock advisory centers, with higher average temperatures and foot and mouth disease, limiting access to export markets. The mean technical efficiency scores for beef production for agricultural districts in class one and two were 62 and 59%, respectively, implying high potential to improve beef production using the same level of agricultural inputs through efficiency-enhancing investments.DiscussionBased on our results, it is crucial for agricultural policies to prioritize regionally specific investments that address the needs of the under-performing districts. By targeting the lagging districts, policymakers can help beef producers improve their input efficiency and bridge the technological gaps to the meta-frontier. This can be achieved through investments in infrastructure, access to livestock advisory services, and disease control measures. Such efforts will not only enhance the efficiency of beef production but also contribute to the overall sustainability of the agricultural sector in Botswana.
The Effects of Temperature and Humidity Index on Growth Performance, Colon Microbiota, and Serum Metabolome of Ira Rabbits
Authors: Li Keyao , Abdelsattar Mahmoud M. , Gu Mingming , Zhao Wei , Liu Haoyu , Li Yafei , Guo Pingting , Huang Caiyun , Fang Shaoming , Gan Qianfu 
Published: June 2023

This study investigates the effects of different THI values on growth performance, intestinal microbes, and serum metabolism in meat rabbits. The results showed that there were significant differences in THI in different location regions of the rabbit house. The high-THI group (HG) could significantly reduce average daily gain and average daily feed intake in Ira rabbits (p < 0.05). The low-THI group (LG) significantly increased the relative abundance of Blautia (p < 0.05). The HG significantly increased the relative abundance of Lachnospiraceae NK4A136 group and reduced bacterial community interaction (p < 0.05). The cytokine–cytokine receptor interactions, nuclear factor kappa B signaling pathway, and toll-like receptor signaling pathway in each rabbit’s gut were activated when the THI was 26.14 (p < 0.05). Metabolic pathways such as the phenylalanine, tyrosine, and tryptophan biosynthesis and phenylalanine metabolisms were activated when the THI was 27.25 (p < 0.05). Meanwhile, the TRPV3 and NGF genes that were associated with heat sensitivity were significantly upregulated (p < 0.05). In addition, five metabolites were found to be able to predict THI levels in the environment with an accuracy of 91.7%. In summary, a THI of 26.14 is more suitable for the growth of meat rabbits than a THI of 27.25, providing a reference for the efficient feeding of meat rabbits.
Navarro y riojano yasa, vasco jasa: ¿paleoeuropeo *isa / *aisa?
Authors: González Bachiller Fabián 
Published: June 2023

Se estudia en este trabajo la difusión de la voz yasa ‘torrentera’, ‘crecida’, tanto en la toponimia (medieval y moderna) como en el habla de hoy; el área de difusión de dicha voz comprende solamente La Rioja oriental y Navarra meridional.
Se pone en relación con el vasco jasa ‘lluvia fuerte’, así como con el topónimo altoaragonés Chasa, y se formula la hipótesis de que el origen de todas estas formas puede estar en la raíz paleoeuropea, de carácter hidronímico, *isa / *aisa, acaso a través de la variante *iasa.
SEJARAH PENDIDIKAN ISLAM PADA MASA DINASTI FATIMIYAH DI MESIR ( 909 – 1171 M )
Authors: Permatasari Tia , Ulya Neng 
Published: June 2023

Dinasti Fatimiyah adalah Dinasti Syiah yang didirikan oleh Ubaidullah Almahdi. Dinasti ini dari tahun 909 hingga 1171 Masehi. Fatimiyah adalah dinasti Syiah yang diperintah oleh 14 khalifah. Dinasti ini didirikan oleh keturunan Nabi Muhammad melalui Ali bin Abi Thalib dan Fathimah. Kata Fatimiyah berasal dari Fatimah Az Zahra binti Rasulullah SAW. Wilayah dinasti Fatimiyah adalah Afrika Utara, Mesir, dan Suriah. Lembaga pendidikan yang digunakan oleh dinasti Fatimiyah antara lain: Masjid, Istana, Perpustakaan dan Dar Al – 'Ilmu. Mengembangkan pengetahuan tentang dinasti Fatimiyah seperti: Bahasa dan Sastra, Filsafat, Kedokteran dan Sya’ir. Tujuan penulisan in adalah untuk mendeskripsikan sejarah pendidikan Islam pada masa dinasti Fatimiyyah di wilayah Mesir. Metode yang digunakan adalah study literatur.
KONTRIBUSI PEMIKIRAN FILSAFAT IQBAL BAGI PENEGAKAN HAK ASASI MANUSIA
Authors: Anshori Lidinillah Mustofa 
Published: June 2023

Abstrak
Hak Asasi Manusia (HAM) merupakan anugerah Tuhan yang diberikan kepada manusia sejak lahir. Namun dalam kehidupan sosial masyarakat, fenomena pelanggaran Hak Asasi Manusia (HAM) masih terjadi sepanjang tahun, selain itu kurangnya kesadaran pentingnya untuk menghargai Hak Asasi Manusia (HAM) masih terjadi pada kalangan masyarakat. Sehingga masyarakat harus dapat mempraktekan hak yang seharusnya dimiliki oleh masing-masing individu dalam kehidupan masyarakat. Salah satu tokoh pemikir yaitu Iqbal memiliki gagasan tentang kemanusiaan yang progresif pemikirannya tentang manusia. Progresivitas Iqbal juga nampak dalam pendapatnya bahwa ada dua cara peneguhan diri sehingga manusia menjadi eksis, yakni cara intelektual dan cara vital. Kedua cara itu sama-sama penting dan sama-sama diperlukan. Metode dalam penelitian ini yaitu kualitatif yang didukung berbagai sumber referensi yang mendukung. Hasil dari kajian ini menunjukkan bahwa pemikiran filsafat Iqbal memiliki kontribusi dalam upaya penegakan Hak Asasi Manusia, karena relevan dengan prinsip-prinsip pelaksanaan Hak Asasi Manusia (HAM)

Kata Kunci : Hak Asasi Manusia, Filsafat Iqbal, Progresivitas, kemanusiaan
Hubungan Pengetahuan Mengenai Gigi Tiruan dengan Status Kebersihan Gigi dan Mulut pada Pengguna Gigi Tiruan Usia 40-50 Tahun
Authors: Sondang Sondang , Rosma Manta , Simaremare Rosdiana T. 
Published: June 2023

Abstract: Knowledge of dentures affects dental and oral hygiene status. This study aimed to determine the relationship between knowledge about denture with dental and oral hygiene status (OHI-S) among denture wearers aged 40-50 years. This was a descriptive and analytical study with a cross sectional design. Samples were 40 denture wearers of Desa Tanjung Morawa B Dusun IV Kabupaten Deli Serdang, Indonesia. The results showed that eight subjects (20.0%) had good knowledge about dentures, 22 subjects (55.0%) had fair knowledge about dentures, and 10 subjects (25.0%) had poor knowledge about dentures. Examination of dental and oral hygiene status (OHI-S) showed nine subjects (22.5%) had good dental and oral hygiene, 18 subjects (45.0%) had moderate dental and oral hygiene, and 13 subjects (32.5%) had poor dental and oral hygiene. The chi-square test showed a relationship between knowledge and status of dental and oral hygiene among the subjects (p=0.03). In conclusion, there is a relationship between knowledge about denture with dental and oral hygiene status among denture wearers at Desa Tanjung Morawa B Dusun IV Kabupaten Deli Serdang, Indonesia.
Keywords: knowledge about wearing denture; dental and oral hygiene; denture wearers

Abstrak: Pengetahuan tentang gigi tiruan memengaruhi status kebersihan gigi dan mulut. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan mengenai penggunaan gigi tiruan dengan status kebersihan gigi dan mulut pada pengguna gigi tiruan berusia 40-50 tahun. Jenis penelitian ialah deskriptif dengan desain potong lintang. Sampel penelitian sebanyak 40 orang masyarakat Desa Tanjung Morawa B Dusun IV Kabupaten Deli Serdang pengguna gigi tiruan, yang dilakukan pengukuran tingkat pengetahuan serta tingkat kebersihan gigi dan mulut (OHI-S). Analisis data menggunakan uji statistik chi-square. Hasil penelitian memperlihatkan bahwa untuk tingkat pengetahuan tentang penggunaan gigi tiruan terdapat delapan subyek (20,0%) memiliki pengetahuan baik, 22 subyek (55,0%) memiliki pengetahuan cukup, dan 10 subyek (25,0%) memiliki pengetahuan kurang. Penilaian tingkat kebersihan gigi dan mulut (OHI-S) mendapatkan sembilan subyek (22.5%) dengan status kebersihan gigi baik, 18 subyek (45,0%) dengan status kebersihan gigi sedang, dan 13 subyek (32,5%) dengan status kebersihan gigi buruk. Hasil uji statistik menunjukkan hubungan antara pengetahuan dengan status kebersihan gigi dan mulut pada pengguna gigi tiruan usia 40-50 tahun (p=0,03). Simpulan penelitian ini ialah terdapat hubungan pengetahuan mengenai penggunaan gigi tiruan dengan status kebersihan gigi dan mulut pada pengguna gigi tiruan usia 40-50 tahun di Desa Tanjung Morawa B Dusun IV Kabupaten Deli Serdang
Kata kunci: pengetahuan mengenai penggunaan gigi tiruan; status kebersihan gigi dan mulut; pengguna gigi tiruan
Energy distribution function of substrate incident negative ions in magnetron sputtering of metal-doped ZnO target measured by magnetized retarding field energy analyzer
Authors: Matsuda Yoshinobu , Watanabe Koki , Uzunoe Shoma , Furusato Tomohiro 
Published: June 2023

Abstract
The energy distribution function of the substrate incident negative ions during magnetron sputtering of a metal-doped zinc oxide target was measured using a home-made retarding field energy analyzer (RFEA) with a magnetic field region. The cross-field region in front of the RFEA injection aperture allows the bulk electrons in the plasma into the RFEA are dramatically suppressed, while the inflow of negative ions emitted from the oxide target is largely unaffected. Negative ions were found to be mainly emitted from the target erosion area and incident on the opposing substrate with ion energy equivalent to the target applied voltage. Compared to energy-resolved mass spectrometers, which require differential pumping and are large and not very portable, magnetized RFEA is inexpensive, compact and easy to sweep in space, although there is no mass separation.
Instant switching control between two types of plasma-driven liquid flows
Authors: Kawasaki Toshiyuki , Shen Kecheng , Shi Heping , Koga Kazunori , Shiratani Masaharu 
Published: June 2023

Abstract
Plasma-driven liquid flows that are generated in bulk liquid by plasma irradiation are one of the key factors in understanding the interaction between plasma and liquid. In this work, the direction of the plasma-driven liquid flow was successfully switched and controlled only by changing the frequency of argon plasma jet generation. The liquid flow could switch in the opposite direction within 3 s after the frequency change. Changes in the emission spectra with frequency have an important effect on the liquid flows, with results from current waveforms indicating that the frequency also changes the characteristics of the plasma jet.