bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accurate ab initio potential energy surface, rovibrational energy levels and resonance interactions of triplet (X~3B1) methylene
Authors: Egorov Oleg , Rey Michaël , Viglaska Dominika , Nikitin Andrei V. 
Published: September 2023

AbstractIn this work, we report rovibrational energy levels for four isotopologues of methylene (CH2, CHD, CD2, and 13CH2) in their ground triplet electronic state (3B1) from variational calculation up to ~10,000 cm−1 and using a new accurate ab initio potential energy surface (PES). Triplet methylene exhibits a large‐amplitude bending vibration and can reach a quasilinear configuration due to its low barrier (~2000 cm−1). To construct the ab initio PES, the Dunning's augmented correlation‐consistent core‐valence orbital basis sets were employed up to the sextuple‐ζ quality [aug‐cc‐pCVXZ, X = T, Q, 5, and 6] combined with the single‐ and double‐excitation unrestricted coupled cluster approach with a perturbative treatment of triple excitations [RHF‐UCCSD(T)]. We have shown that the accuracy of the ab initio energies is further improved by including the corrections due to the scalar relativistic effects, DBOC and high‐order electronic correlations. For the first time, all the available experimental rovibrational transitions were reproduced with errors less than 0.12 cm−1, without any empirical corrections. Unlike more “traditional” nonlinear triatomic molecules, we have shown that even the energies of the ground vibrational state (000) with rather small rotational quantum numbers are strongly affected by the very pronounced rovibrational resonance interactions. Accordingly, the polyad structure of the vibrational levels of CH2 and CD2 was analyzed and discussed. The comparison between the energy levels obtained from the effective Watson A‐reduced Hamiltonian, from the generating‐function approach and from a variational calculation was given.
Nonsense‐mediated mRNA decay suppresses injury‐induced muscle regeneration via inhibiting MyoD transcriptional activity
Authors: Tan Yanjie , Zhang Jing , Jin Yi 
Published: September 2023

AbstractSkeletal muscle regeneration is a crucial physiological process that occurs in response to injury or disease. As an important transcriptome surveillance system that regulates tissue development, the role of nonsense‐mediated mRNA decay (NMD) in muscle regeneration remains unclear. Here, we found that NMD inhibits myoblast differentiation by targeting the phosphoinositide‐3‐kinase regulatory subunit 5 gene, which leads to the suppression of the transcriptional activity of myogenic differentiation (MyoD), a key regulator of myoblast differentiation. This disruption of MyoD transcriptional activity subsequently affects the expression levels of myogenin and myosin heavy chain, crucial markers of myoblast differentiation. Additionally, through up‐frameshift protein 1 knockdown experiments, we observed that inhibiting NMD can accelerate muscle regeneration in vivo. These findings highlight the potential of NMD as a novel therapeutic target for the treatment of muscle‐related injuries and diseases.
Correlation of ultrasound features with Bcl‐2 protein expression in basal cell carcinomas (BCCs)
Authors: Luo Ping‐ping , Chen Yan‐xuan , Zhong Zhi‐rong , Feng Ming‐chu , Wang Jing , Liang Jian‐feng 
Published: September 2023

AbstractBackgroundThe expression of the Bcl‐2 protein is frequently observed in basal cell carcinomas (BCCs), making it a significant biological marker and potential therapeutic target. Skin ultrasonography offers a noninvasive means of obtaining anatomical information about cutaneous tumors.ObjectivesThe purpose of this study was to investigate the correlation between ultrasound features and Bcl‐2 expression in BCCs, to provide a reference for developing pharmacological treatment plans.MethodsAccording to the Bcl‐2 protein expression, 74 BCCs confirmed by surgical pathology were divided into high Bcl‐2 expression BCCs (HB‐BCCs) and low Bcl‐2 expression BCCs (LB‐BCCs). Preoperative lesion ultrasound features were analyzed retrospectively based on Liang's criteria, which included the following features: shape, surface, keratinization, base, infiltration level, internal echogenicity, distribution of hyperechoic spots, posterior echogenic changes, internal Doppler signal, and lesion size (maximum diameter and infiltration depth). The differences of two groups were compared using a chi‐square test or a paired t‐test.ResultsBased on ultrasound features, cystic areas were more frequent in LB‐BCCs (χ2 = 7.015, P = .008). Furthermore, LB‐BCCs exhibited greater infiltration depth than HB‐BCCs (4.86 ± 2.12 mm vs. 2.72 ± 1.40 mm, P = .000), had a higher propensity to infiltrate the subcutaneous tissue (χ2 = 12.422, P = .002), and displayed a more abundant internal Doppler signal within the lesions (χ2 = 24.696, P = .000). Conversely, maximum diameter of the lesions, shape, surface, keratinization, base, hyperechoic spots distribution, and posterior echogenic changes of the lesions did not differ significantly between the two groups.ConclusionsUltrasound features are correlated with Bcl‐2 protein expression level in BCCs. LB‐BCCs show greater infiltration depth, subcutaneous infiltration, more cystic changes and more abundant internal Doppler signal than HB‐BCCs, which may suggest a potential basis for drug selection in BCC chemotherapy.
Roles of thermal advection in setting the Southern Ocean warming pattern
Authors: Wei Yanzhou 
Published: September 2023

AbstractThe Southern Ocean is the major region of global ocean heat gain. Most of the heat gain is concentrated in the region of the Antarctic Circumpolar Current (ACC), but SST within the ACC only exhibits a slight increase. Ocean circulation plays a fundamental role in setting the pattern of temperature response to global warming. In this study, a 1/4° Southern Ocean eddy‐permitting model configured based on the Regional Ocean Modeling System is used to study the role of ocean in setting the warming pattern, by examining the response of ocean temperature and heat budget terms to a uniform air–sea heat flux (Qnet) increase. As Qnet increases by a constant value, the SST increases, but with a smaller value within the ACC region. Consequently, more heat flux in the ACC region is induced from the atmosphere to the ocean through thermal adjustment. Heat budget analyses suggest that the surface warming induced by vertical diffusion is largely offset by the cooling effect of heat advection, especially within the ACC region; however, in the subsurface, the effect of vertical diffusion becomes slight, and heat advection dominates the temperature change and induces warming in the ACC region. These results highlight the importance of heat advection in setting the temperature response pattern to air–sea heat flux increase: by transporting more heat from the surface to the deep ocean, the SST increase within the ACC region becomes smaller, and this induces more heat flux from the atmosphere to the ocean and thus makes the ACC region become a major region of heat gain.
Fabrication and stability of W/O/W emulsions stabilized by gum arabic and polyglycerol polyricinoleate
Authors: Niu Fuge , Zhao Mengdi , Tu Weiwei , Li Zhe , Gao Yi , Du Yixuan , Pan Weichun 
Published: September 2023

AbstractBACKGROUNDIn order to study the effect of adsorption of surfactant at the two interfacial layers on emulsion stability, the kinetically stable water‐in‐oil‐in‐water (W/O/W) emulsion carriers were prepared using polyglycerol polyricinoleate (PGPR) and gum arabic (GA) as emulsifiers. The relationship between the adsorption of the surfactant and the stability mechanism of the emulsions was elucidated.RESULTSWhen the contents of PGPR and GA were low, the interfaces between oil and the inner and outer water phases, respectively, could not be completely covered. However, when the concentration of PGPR was higher than 60 g kg−1, the excess PGPR was adsorbed on the interface between the oil phase and the outer water phase. When the concentration of GA reached 80 g kg−1, more GA was adsorbed to the oil‐in‐water interface. Moreover, the presence of PGPR on the interface could reduce the adsorption capacity of GA. Two types of kinetically stable emulsions were obtained by optimizing the interface composition (60 g kg−1 GA/80 g kg−1 PGPR and 60 g kg−1 PGPR/80 g kg−1 GA). The kinetically stable W/O/W emulsions prepared in this study were successfully used to encapsulate a hydrophilic vitamin (vitamin B12) with an encapsulation efficiency (EE) of 80% and release efficiency (RE) of 95%. The interfacial adsorption GA can accelerate the hydrolysis of fat.CONCLUSIONOverall, this study provides a new strategy for the preparation of W/O/W emulsions, which might be beneficial for application in food, cosmetic, chemical, and pharmaceutical industries. © 2023 Society of Chemical Industry.
Ocrelizumab‐induced psoriasiform dermatitis: Case reports and review of the literature
Authors: Naranjo Guerrero Natalia , González Quesada Alicia , García Minarro Angela , Castro González Elena , Paredes Pérez Ana Begoña , Carretero Hernández Gregorio 
Published: September 2023

AbstractOcrelizumab (OCR) is a humanized anti‐CD20 monoclonal antibody approved for treating multiple sclerosis. We present three patients who developed psoriasiform dermatitis (PsD) during OCR treatment and a review of the cases published to date. We hereby report the first exclusive fingernail involvement. Most of the cases had a mild skin involvement and only one case required OCR discontinuation. No association with arthritis, personal or family history of psoriasis was found. Data compiled suggests that PsD tends to appear within the first year of treatment. There are few studies focusing on B‐lymphocytes in psoriasis and several hypotheses attempt to explain their role. The most widely accepted is the depletion of regulatory B‐lymphocytes with immunomodulatory function through interleukin‐10. However, the exact mechanism by which this occurs with OCR remains unclear and the presented case of anti‐CD20‐induced PsD highlights the importance of continuous monitoring of new treatments in terms of dermatological side effects and the induction of skin diseases, in particular psoriasis. There is also a need to inform the professional community about the possibility of psoriasis in patients with multiple sclerosis and the consequences of this condition.
Experimental research in knowledge management
Authors: Frissen Ilja , Evans M. Max 
Published: September 2023

AbstractAt the heart of any healthy field are explicit theories and concerted efforts to test these theories. In the traditional “textbook” conceptualization of science, the main avenue for developing and testing theory is experimental research, a tool that enables investigators to filter out the noise in order to draw logically valid inferences and conclusions. The objective of this paper is to begin a probe into the use of experimental research in knowledge management (KM). After sketching an image of the nature of experimental research and its advantages, the paper details the results of an analysis of experimental research in the KM literature. The top 20 KM journals were searched in Scopus and Web of Science for any mention of the term “experiment.” In total, 43 papers were identified based on their use of experimental methods and human participants. These studies were coded for purpose, research questions, hypotheses, operationalization of variables, sample parameters, and statistical analysis methods. There appeared to be little evidence for a dedicated and sustained use of experimental research methods. Virtually all studies relied heavily on self‐report questionnaires as the main data collection tool rather than direct behavioral measures. Potential implications are that KM journals may want to elicit and encourage more experimental research, and researchers interested in using experimental methods may want to forge multidisciplinary partnerships, for instance, with experimental psychologists. The implication for KM methodological pedagogy is to further promote and integrate experimental methods.
A balance among irrigation and fertilization regimes to reduce greenhouse gases emissions from saline and alkaline soils
Authors: Zhang Sheng , Zamanian Kazem , Raza Sajjad , Raheb Alireza , Feng Ying , Zhao Xiaoning 
Published: September 2023

AbstractAgricultural practices of nitrogen and irrigation overuse bring lots of environmental problems, such as greenhouse gases (GHGs) emissions, soil, and water pollution. With the fast expansion of saline and alkaline agricultural soils in the Tarim River Basin, field practice must be very cautious facing water limitations and global warming. The GHGs were measured 1–2 times weekly and water and fertilizer use efficiency were evaluated under five treatments: (1) fallow (Control); (2) no N (kg N ha−1) and no irrigation (mm) (0N0W); (3) 200 and 355 (LNLW); (4) 230 and 475 (MNMW), and (5) 320 and 655 (HNHW) (traditional treatment) from 2018 to 2019 under maize in Aksu in the Tarim River Basin. The GHGs increased with fertilization and irrigation. The cumulative GHGs were 0.6–5.9 Mg CO2–C ha−1, 0.2–3.6 kg N2O–N ha−1, and increased significantly with biomass increase. The cumulative CH4 was −0.03 to −0.12 kg C ha−1. The MNMW resulted in the highest average water use efficiency (27 kg ha−1 mm−1), irrigation water use efficiency (32 kg ha−1 mm−1), and agronomic N use efficiency (44 kg kg−1), but the lowest greenhouse gas intensity (0.4 kg CO2‐eq ha−1 grain yield). The MNMW reduced the average of 10 mm water, 5 kg N ha−1 fertilizer, and 4 × 10−3 kg CO2‐eq ha−1 GHGI earning 1 t ha−1 maize compared to HNHW. The CO2 emission had a strong relationship with temperature (T) and soil moisture (W) (CO2 emission = (exp (a + bW + cW2)) Q10(T‐20)/10)) (R2 = 0.59–0.92). The lowest was in the LNLW treatment in 2019; the highest was in the HNHW in 2018). The emission of CO2 responding to fertilization was below the global trend, but that of N2O was above under maize in saline and alkaline soils (pH 7–9). In conclusion, MNMW was the best field management to mitigate GHGs with the highest water and fertilizer use efficiency under maize in saline and alkaline soils in Tarim River Basin, where had the higher N2O emission risk.
A narrative review on nutritional and health benefits of underutilized summer crop to address agriculture challenges: Moth bean (Vigna aconitifolia L.)
Authors: Rani Jyoti , Dhull Sanju Bala , Kinabo Joyce , Kidwai Mohd. Kashif , Sangwan Amit 
Published: September 2023

AbstractA reasonable plant‐based protein supply needs to be found in order to fight protein undernourishment, especially in developing nations. One of the most prominent and underutilized members of the Fabaceae family, moth bean (Vigna aconitifolia L.), has outstanding nutritional and bioactive components. Moth bean is a tropical crop and has ability to grow well at arid and semiarid areas. In addition to vitamins, minerals, lipids, fatty acid, and carbohydrate, moth bean seeds also provide an abundant protein source. Furthermore, the antioxidant and phenolic content of moth bean seeds is also high. If consumed on a regular basis, moth bean legume possesses countless beneficial effect on health and immune system, including the ability to prevent obesity, diabetes, and cardiac diseases in humans. This review focuses on the uses, improved varieties, adaptive constrain, nutritional bioavailability, and health benefits of V. aconitifolia seeds.
Enzyodynamic therapy at nanoscale
Authors: Wang Zeyu , Song Xinran , Huang Hui , Chang Meiqi , Chen Yu 
Published: September 2023

AbstractArtificial enzymes featuring the desirable catalytic activity built on nanomaterials are known as nanozymes. Compared with the natural counterparts, nanozymes have demonstrated distinct characteristics including cost‐effectiveness, ease of preparation, high stability, and excellent recycling efficiency. With the rapid innovation of nanoscience and technology, a growing number of nanozymes have been deeply applied in disease prevention, diagnosis, and treatment. In addition, a multimodal platform for effectively interacting with complicated biologic settings has also been achieved by the inherent nanomaterial and dynamic features of nanozymes, which goes beyond simply serving as an enzyme substitute. In this review, we systematically discuss and highlight the classification and catalytic mechanism of nanozymes, regulation of nanozyme activity as well as the research progresses of nanozyme‐enabled/augmented enzyodynamic therapy in treating cancer based on producing and eliminating reactive oxygen species, bacterial infection, inflammation, neurodegeneration, and radiation‐induced tissue damage. Furthermore, the current challenges and future development direction of nanozymes in enzyodynamic disease therapy have been outlined and outlooked. It is highly anticipated that this review will be of guiding significance for better understanding the physiochemical properties and biological effect of nanozymes and the corresponding emerging enzyodynamic disease therapeutics.
Segmentation of carotid artery vessel wall and diagnosis of carotid atherosclerosis on black blood magnetic resonance imaging with multi‐task learning
Authors: Wu Jiayi , Xin Jingmin , Yang Xiaofeng , Matkovic Luke A. , Zhao Xihai , Zheng Nanning , Li Rui 
Published: September 2023

AbstractBackgroundAtherosclerotic cardiovascular disease is the leading cause of death worldwide. Early detection of carotid atherosclerosis can prevent the progression of cardiovascular disease. Many (semi‐) automatic methods have been designed for the segmentation of carotid vessel wall and the diagnosis of carotid atherosclerosis (i.e., the lumen segmentation, the outer wall segmentation, and the carotid atherosclerosis diagnosis) on black blood magnetic resonance imaging (BB‐MRI). However, most of these methods ignore the intrinsic correlation among different tasks on BB‐MRI, leading to limited performance.PurposeThus, we model the intrinsic correlation among the lumen segmentation, the outer wall segmentation, and the carotid atherosclerosis diagnosis tasks on BB‐MRI by using the multi‐task learning technique and propose a gated multi‐task network (GMT‐Net) to perform three related tasks in a neural network (i.e., carotid artery lumen segmentation, outer wall segmentation, and carotid atherosclerosis diagnosis).MethodsIn the proposed method, the GMT‐Net is composed of three modules, including the sharing module, the segmentation module, and the diagnosis module, which interact with each other to achieve better learning performance. At the same time, two new adaptive layers, namely, the gated exchange layer and the gated fusion layer, are presented to exchange and merge branch features.ResultsThe proposed method is applied to the CAREII dataset (i.e., 1057 scans) for the lumen segmentation, the outer wall segmentation, and the carotid atherosclerosis diagnosis. The proposed method can achieve promising segmentation performances (0.9677 Dice for the lumen and 0.9669 Dice for the outer wall) and better diagnosis accuracy of carotid atherosclerosis (0.9516 AUC and 0.9024 Accuracy) in the “CAREII test” dataset (i.e., 106 scans). The results show that the proposed method has statistically significant accuracy and efficiency.ConclusionsEven without the intervention of reviewers required for the previous works, the proposed method automatically segments the lumen and outer wall together and diagnoses carotid atherosclerosis with high performance. The proposed method can be used in clinical trials to help radiologists get rid of tedious reading tasks, such as screening review to separate normal carotid arteries from atherosclerotic arteries and to outline vessel wall contours.
Implications of COVID‐19 in Airway and Swallowing Function
Authors: Linquest Lauren , Ackerman Kayla , Dewan Karuna 
Published: September 2023

AbstractObjectiveThe acute treatment and complications of the novel COVID‐19 virus have been well studied, but the implications of this novel virus for swallowing function continue to be investigated. The goal of this study is to retrospectively assess airway and swallowing outcomes for those patients who required intensive care unit(ICU)‐level care for COVID‐19 infection.Study DesignComparison of swallowing outcomes through diet change in COVID‐19 patients in the Ochsner‐Louisiana State University (LSU) Hospital ICU.SettingOchsner‐LSU Hospital (Shreveport, Louisiana).MethodsA retrospective chart review was performed from March 2020 to May 2022 to identify patients with a primary diagnosis of COVID‐19. Variables analyzed include age, gender, length of intubation, length of ventilation, airway interventions, use of extracorporeal membrane oxygenation, and diet prior to, during, and after hospitalization for COVID‐19 infection.ResultsTwo hundred and seven patients fit the inclusion criteria. There was a significant difference in discharge diet between those patients who were intubated and those who were not (P = .007). Thirty percent of patients were discharged on a different diet than their baseline with patients on a nonregular diet significantly more likely to discharge to a facility (P = .043). Negative vaccine status was associated with prolonged ICU stay, prolonged duration of intubation, and prolonged duration of ventilation.ConclusionCOVID‐19 continues to present novel challenges with new implications and outcomes being discovered in the third year of the pandemic. Further research is necessary to determine the most effective treatment approaches with respect to optimized speech and swallow outcomes.
A comprehensive review of the recent developments in thermoplastics and rubber blends‐based composites and nanocomposites
Authors: Urtekin Gizem , Ullah Muhammad Saeed , Yildirim Rumeysa , Ozkoc Guralp , Kodal Mehmet 
Published: September 2023

AbstractVarious blends and composites have been prepared during the past decade to address limitations, including the poor mechanical properties of polymers, or to balance out the high cost of synthetic polymers. Rubber‐based thermoplastic blends and composites are being developed to attain improved performance and balanced qualities for usage in a variety of industries, including automotive, packaging, home products, space technology, and biomedical. Thermoplastics can be produced via standard manufacturing procedures and have outstanding qualities like low density, good chemical resistance, and heat resistance. However, rubbers are being used because of their elastic attributes, including their resilience, impact resistance, and good tear strength. These two materials work well together when blended or combined. In this article, an effort was made to narrow the gap between rubbers and thermoplastics. The mechanical, rheological, and morphological properties of the rubber/thermoplastic blends and composites/nanocomposites containing various types of conventional fillers and nanofillers were discussed comprehensively. Blends of these materials can provide too easier melt processing as well as financial benefits. The flexible nature and damping properties of rubber and better thermal stability and thermoplastic processability contributed to the development of high‐performance rubber/thermoplastic composites with better ductility, impact strength, and stiffness. Rubber reduced the high brittleness of thermoplastics because of its resilience and damping properties. In contrast, the poor processability and weak chemical resistance of rubbers were overcome via better processability and higher stiffness of thermoplastics. Rubber‐based thermoplastic composites and nanocomposites have been reported to offer greater flexibility, better processing, high impact strength, and chemical resistance.Highlights
The properties of rubber/thermoplastic blends were discussed in this article.
More recent advancements in rubber/thermoplastic blends were evaluated.
Morphological properties depend on the rubber/thermoplastic blend ratio.
The addition of reinforcements affects the rheological properties.
Dispersion of additives and blend ratio influence the mechanical properties.