bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-Time Monitoring of Weather Radar Network Calibration and Antenna Pointing
Authors: Louf Valentin , Protat Alain 
Published: April 2023

Abstract
We present an integrated framework that leverages multiple weather radar calibration and monitoring techniques to provide real-time diagnostics on reflectivity calibration, antenna pointing, and dual-polarization moments. This framework uses a volume-matching technique to track the absolute calibration of radar reflectivity with respect to the Global Precipitation Measurement (GPM) spaceborne radar, the relative calibration adjustment (RCA) technique to track relative changes in the radar calibration constant, the solar calibration technique to track daily change in solar power and antenna pointing error, and techniques that track properties of light-rain medium to monitor the differential reflectivity and dual-polarization moments. This framework allows for an evaluation of various calibration and monitoring techniques. For example, we found that a change in the RCA is highly correlated to a change in absolute calibration, with respect to GPM, if a change in antenna pointing can first be ruled out. It is currently monitoring 67+ radars from the Australian radar network. Because of the diverse and evolving nature of the Australian radar network, flexibility and modularity are at the core of the calibration framework. The framework can tailor its diagnostics to the specific characteristics of a radar (band, beamwidth, etc.). Because of its modularity, it can be expanded with new techniques to provide additional diagnostics (e.g., monitoring of radar sensitivity). The results are presented in an interactive dashboard at different level of details for a wide and diverse audience (radar engineers, researchers, forecasters, and management), and it is operational at the Australian Bureau of Meteorology.

Significance Statement
Weather radars, like all instruments, require maintenance and upgrades. Rainfall measurements are highly variable and sensitive to change, and this can lead to inconsistencies within a radar network. Calibration is the process to counteract those inconsistencies. Any calibration requires a fixed standard to which the changed/upgraded radar can be compared. The SCAR calibration framework presented herein makes use of several standards to retrieve a full set of diagnostics about the radar data. We apply these techniques over the entire Australian weather radar network and demonstrate that, by using this integrated approach, absolute calibration can be achieved to within 1 dBZ of reflectivity, antenna pointing can be monitored within 0.1°, and the various measurements of the radars can be quality controlled.
Network of burnout, depression, anxiety, and dropout intention in medical undergraduates
Authors: Peng Pu , Chen Shubao , Hao Yuzhu , He Li , Wang Qianjin , Zhou Yanan , Tang Yi-Yuan , Yang Winson Fuzun , Wu Qiuxia , Liu Tieqiao 
Published: April 2023

Background: Burnout, depression, and anxiety are highly prevalent among medical students, which often leads to their attrition. We aim to assess the inter-relationships of depression, burnout, and anxiety symptoms with dropout intention among Chinese medical undergraduates using the network analysis. Method: A total of 3,648 Chinese medical undergraduates were recruited through snowball sampling. Learning burnout scale, 9-item Patient Health Questionnaire (PHQ-9), and General Anxiety Disorder Scale (GAD-7) was used to assess burnout, depression, and anxiety symptoms, respectively. We used the EBICglasso model to estimate the network. We compared the network based on gender, study phase, and clinical experience. Results: After removing repeated submissions and incorrect responses to the trap question, 3,536 participants were included in the final analysis. The prevalence of burnout, depression, anxiety, and dropout intention was 38, 62.7, 38.4, and 39% respectively, which is consistent with previous findings. Network analysis suggested that anxiety and depression items clustered together and displayed several strong bridge connections, while burnout items formed another cluster. All the strongest edges were within the respective distress. Cynicism symptoms ‘I am fed up with study’ and ‘I want to study but I feel that studying is boring’ were the most central symptoms, while ‘fatigue’ and ‘worthless’ were the bridge symptoms within the burnout-depression-anxiety network. Other central symptoms included ‘worthless’, ‘I can handle my courses’, ‘nervous’, and ‘uncontrollable worry’. Cynicism symptoms ‘I am interested in my major’ and ‘I feel that the knowledge I have learned is useless’ were mostly related to dropout intention. Gender, study phase, and clinical experience didn’t affect the global strength of the burnout-depression-anxiety network. Conclusion: Our results indicated the predominance of cynicism symptoms within the burnout-depression-anxiety network and its substantial impact on dropout intention, suggesting that early detection and intervention for cynicism symptoms in Chinese medical students are in urgent need. Other central and bridge symptoms might also serve as potential targets for the prevention and treatment of burnout, depression, and anxiety among medical students. For example, studies suggest cognitive-behavioral therapy could quickly improve ‘worthless’, which might be beneficial in treating burnout, depression, and anxiety in medical students.
Suicides among Children and Adolescents in Paraguay: An 18-year National Exploratory Study (2004–2022)
Authors: Torales Julio , Barrios Iván , Tullo-Gómez Juan Edgar , Melgarejo Osvaldo , Gómez Nora , Riego Viviana , Navarro Rodrigo , García Oscar , Figueredo Pamela , Almirón-Santacruz José , Caycho-Rodríguez Tomás , Castaldelli-Maia João Mauricio , Ventriglio Antonio 
Published: April 2023

Background:Suicide and suicide attempts are impacting events for patients and their relatives, and these behaviors are still taboo among adults and may be even more traumatic when involving children and adolescents.Aim:In this study we aimed to describe suicide rates among children and adolescents in Paraguay over the last decades as well as associated factors such as sociodemographic characteristics and methods used for suicide.Methods:This was an observational and exploratory study describing the frequency and characteristics of suicide among children and adolescents in Paraguay between 2004 and 2022. Official records of all deaths by suicide were reviewed, and statistical analyses were performed. In addition, an attempt was made to predict the number of suicides in the next 5 years using a mathematical model based on simple linear regression.Results:In the 18-year period observed, 940 suicides among children and adolescents were recorded. The mean age was 15.05 ± 1.8 years old. Of these, 51.17% were male, 74.6% were from urban areas, and 22.2% were from the Greater Asunción and Central Department of Paraguay. The most frequently used method of suicide was intentional self-inflicted injury by hanging, strangulation, or suffocation, which all represented 75.3% of the cases. Our mathematical modeling based on simple linear regression determined that the expected yearly number of national suicides in the pediatric population for the following years, from 2023 to 2027, will range between 72 and 81.Conclusion:This study is the first large national epidemiological report on the emerging issue of suicide among children and adolescents in Paraguay. It may be a relevant source of information for mental health professionals, health authorities, and decision makers to develop national prevention strategies and actions against suicide among youths.
Uterine artery embolization for postpartum hemorrhage with placenta accreta spectrum
Authors: Jeon Go Un , Jeon Gyeong Sik , Kim Young Ran , Ahn Eun Hee , Jung Sang Hee 
Published: April 2023

Background The reported success rate of uterine artery embolization (UAE) for postpartum hemorrhage (PPH) differs by the cause of bleeding; in some reports, UAE shows less successful results in patients with placenta accreta spectrum (PAS). Purpose To evaluate the outcome of UAE for treating PPH associated with PAS. Material and Methods From September 2011 to September 2021, 227 patients (mean age = 34.67±4.06 years; age range = 19–47 years) underwent UAE for managing intractable PPH. Patients were divided into two groups: those with PAS (n = 46) and those without PAS (n = 181). Delivery details, embolization details, and procedure-related outcomes were compared between the two groups. P values <0.05 were considered statistically significant. Results The technical success rate was 96.9% (n = 222) and the clinical success rate was 93.8% (n = 215). There were no significant differences in outcome of UAE between the two patient groups. The technical success rate was 95.7% (n = 44) in patients with PAS and 98.3% (n = 178) in patients without PAS ( P = 0.267). The clinical success rate was 91.3% (n = 42) in patients with PAS and 95.6% (n = 173) in patients without PAS ( P = 0.269). There were 24 cases of immediate complications, including pelvic pain (n = 20), urticaria (n = 3), and puncture site hematoma (n = 1). No major complication was reported. Conclusion UAE is a safe and effective method to control intractable PPH for patients with or without PAS.
Impact of Old Age on an Occupation’s Image Over 210 Years: An Age Premium for Doctors, Lawyers, and Soldiers
Authors: Ng Reuben , Indran Nicole 
Published: April 2023

As older adults continue to contribute to the labor force, it is critical that perceptions of them reflect these contributions. We explore whether portraying older adults based on their occupational roles instead of their age is linked to more positive sentiments and test the possibility of an age premium. We created the largest historical corpus of American English—a 600-million-word dataset with over 150,000 texts—spanning 210 years (1810–2019). Top descriptors ( N = 675,213) of nouns related to age, occupation, and age × occupation over 21 decades were compiled and rated for valence (negative-positive) on a 5-point scale. Occupational role-based framing was associated with more positive portrayals than age-based framing. Positive portrayals of older lawyers increased by 22.6% over 210 years. Older doctors (−1.4%) and older soldiers (−10.7%) experienced a decline in positive portrayals, though sentiments toward older doctors, lawyers, and soldiers remained more positive than those toward older adults.
Autologous Tooth Transplantation in Craniofacial Malformations
Authors: Naros Andreas , Schulz Matthias , Finke Hannah , Reinert Siegmar , Krimmel Michael 
Published: April 2023

Objective To evaluate the applicability of transplanted teeth in young patients with craniofacial anomalies Design Observational study Setting Comprehensive Centre for Cleft Palate and Craniofacial Malformations Patients/Participants Patients with craniofacial anomalies who underwent tooth transplantation. Only children with complete clinical and radiological documentation and a follow-up period of at least 1.5 years were included. Interventions Tooth transplantation Main Outcome Measure(s) Retrospective evaluation of clinical records, pre- and postoperative radiographs, and operative charts. Clinical characteristics of patients, preoperative parameters and postoperative outcome parameters were collected. Results A total of 17 patients with 23 tooth transplantations were included. The median follow-up period was 6.7 years. The pooled survival and success rates were 91%. Notably, one out of two teeth that were transplanted into the bone grafted alveolar cleft site had to be extracted, which might indicating a higher risk for this procedure. In total, two transplanted teeth had to be extracted during the follow-up period, one due to external resorption and the other one due to perio-endo lesion. One patient needed endodontic treatment due to pulp necrosis. Conclusion We consider tooth transplantation to be a reliable and suitable procedure in the dental rehabilitation of young patients with craniofacial anomalies and fitting concomitant circumstances. We encourage craniofacial teams to reconsider this option more frequently in appropriate cases.
Clinical outcomes of chronic limb-threatening ischemia due to inflammatory nonatherosclerotic versus atherosclerotic etiologies undergoing revascularization
Authors: Iida Osamu , Takahara Mitsuyoshi , Kodama Akio , Yamaoka Terutoshi , Soga Yoshimitsu , Mano Toshiaki 
Published: April 2023

Background: The scope of clinical guidelines for the management of chronic limb-threatening ischemia (CLTI) is limited to atherosclerotic disease of the lower-extremity arteries. This study aimed to reveal the clinical features and prognoses of CLTI due to inflammatory nonatherosclerotic etiologies undergoing revascularization. Methods: DECOPON (DatabasE of ChrOnic limb-threatening ischemia Presenting ischemic ulcer and gangrene due to nON-atherosclerotic disease) is a multicenter retrospective study that evaluated 465 limbs of 414 patients with CLTI undergoing revascularization for ischemic tissue loss with inflammatory nonatherosclerotic etiologies between 2010 and 2020. Clinical features and prognoses were compared with 930 limbs of 809 patients with atherosclerotic CLTI during the same period. Results: The frequency of conventional atherosclerotic risk factors was significantly lower in the inflammatory nonatherosclerotic group. The inflammatory nonatherosclerotic group had more severe WIfI (wound, ischemia, and foot infection) W and fI grades, and more frequent infrapopliteal and inframalleolar artery diseases with a rarer presence of arterial calcification (all p < 0.05). Adjunctive therapy was more frequently performed in the inflammatory nonatherosclerotic group ( p < 0.05). The inflammatory nonatherosclerotic group had a lower incidence rate of wound healing (0.64-fold, p < 0.001) and a higher incidence rate of major reintervention (2.30-fold, p = 0.006), whereas the risk ratio of all-cause mortality was 0.83-fold ( p = 0.067). The association of inflammatory nonatherosclerotic disease with the delayed wound healing and the susceptibility to major reintervention remained significant even after adjustment for covariates (both p < 0.001). Conclusions: Patient, limb, and lesion characteristics of inflammatory nonatherosclerotic CLTI were considerably different from those of atherosclerotic CLTI. Inflammatory nonatherosclerotic CLTI was less likely to heal than atherosclerotic CLTI.
Parental alienation – a valid experience?
Authors: Meland Eivind , Furuholmen Dag , Jahanlu David 
Published: April 2023

Background: The phenomenon of ‘parental alienation’ is controversial and little explored in the Nordic countries. We wanted to investigate whether parental alienation is a valid concept and how it is perceived in a Nordic context. Material and method: The study was based on an online survey where the participants were self-recruited. We received responses from 1212 participants. Bivariate and multivariate models were used to test the associations between parental alienation and gender, other intimate partner violence, depressive health problems and reduced well-being. Results: Visitation sabotage and parental alienation are realities for both fathers and mothers. It was most frequently directed at fathers, but such behaviour is not gender specific. Eight different alienation strategies have high internal reliability, and all items contribute to high Cronbach’s alpha. Construct validity was confirmed by the fact that parental alienation is strongly associated with visitation sabotage and with other forms of destructive relational behaviour. Visitation sabotage and false accusations increase gradually with the degree of parental alienation. The construct validity of parental alienation was also confirmed by dose–response associations with both mental ill-health and impaired well-being in adjusted analyses. Conclusions: The phenomenon of parental alienation is recognized among parents as a form of harmful behaviour where both mothers and fathers suffer. The construct validity was supported in this study. Such behaviour should be recognized as a form of domestic violence by professional communities in health and social services and be subject to legal action.
Severe lupus flare is associated with a much higher risk of stroke among patients with SLE
Authors: Chang Kuo-Cheng , Lin Ching-Heng , Chen Po-Lin , Wu Yu-Hsuan , Hou Chung-Wei , Huang Jin-An 
Published: April 2023

Background and aim: There are few data on the influence of lupus flare on stroke risk in systemic lupus erythematosus (SLE). In this study, we examined whether a severe lupus flare further increases the risk of stroke among SLE patients. Methods: Using the Taiwan’s National Health Insurance Research Database, we conducted a retrospective population-based cohort study from 2000 to 2016. Each patient with SLE was matched to a non-SLE subject in age, sex, and index date. A severe flare of lupus was identified when an SLE patient was admitted for pulse therapy with intravenous methylprednisolone greater than 250 mg in a single hospitalization. SLE patients were divided into severe flare and non-severe flare groups. Results: In total, 334 of 10,006 patients with SLE had a severe lupus flare, and the remaining 9672 patients were assigned to the non-severe flare group. Ischemic stroke occurred in 29 (8.7%), 485 (5%), and 384 (3.8%) of the patients in the severe flare, non-severe flare, and control groups, respectively. Hemorrhagic stroke occurred in 9 (2.7%), 123 (1.3%), and 37 (0.4%) of patients in the severe flare, non-severe flare, and control groups, respectively. Compared with patients in the non-severe flare group, patients with severe flare had a significantly higher risk of ischemic stroke (adjusted hazard ratio (aHR) = 7.44, 95% confidence interval (CI): 4.93–11.25 vs aHR = 1.52, 95% CI: 1.26–1.83) and hemorrhagic stroke (aHR = 22.49, 95% CI: 10.09–50.12 vs aHR = 4.47, 95% CI: 2.90–6.90). Conclusion: Severe lupus flare is associated with a much higher risk of ischemic and hemorrhagic strokes among SLE patients.
Mortality of multiple sclerosis in Iceland population-based mortality of MS in incidence and prevalence cohorts
Authors: Eliasdottir Olöf , Kjartansson Ólafur , Olafsson Elias 
Published: April 2023

Introduction Mortality is an important feature of the natural history of multiple sclerosis (MS). We report the mortality of all individuals with MS in Iceland, identified in a nationwide population-based study. Patients and Methods The results are based on a prevalence cohort and an incidence cohort. The prevalence cohort consisted of all patients with MS (n = 526) living in Iceland on the 31 December 2007. The incidence cohort consisted of all residents of Iceland (n = 222) diagnosed with MS during 2002 to 2007. Mortality was determined by following both the incidence cohort (from diagnosis) and the prevalence cohort (from the prevalence day) until death or 31 December 2020. The mortality, associated with MS, was compared with that expected in the Icelandic population ( standardized mortality ratio (SMR)). Results (a) Prevalence cohort (n = 526). The mean follow up was 12.0 years (range 0.3–13.0). The SMR was 1.6 (95% confidence interval (CI) 1.3–2.0). (b) Incidence cohort (n = 222). The mean follow up was 15.4 years (range 3.7–18.5). The SMR was 1.2 (95% CI 0.6–2.2). Conclusion During the follow-up period, there was a substantial increase in mortality among the patients with MS, compared with the general population. There was no increase in mortality among the incidence cohort, when followed for up to 18.5 years following diagnosis.
Role of p53/circRNA0085439/Ku70 axis in DNA damage response in lung cells exposed to ZnO nanoparticles: Involvement of epigenetic regulation
Authors: Zhou Meiling , Xiao Liang , Jin Jing , Wang Yin , Guo Peiyu , Luo Jinhua , Skonieczna Magdalena , Huang Ruixue 
Published: April 2023

Abstract
Background
Nano-Zinc oxide (Nano-ZnO) has been increasingly applied in agriculture, industry and biomedicine. However, the genotoxic effects of Nano-ZnO and the underlying mechanisms remain incompletely clear.

Methods
Human bronchial epithelial cell line (HBE) was used to observe the effects of Nano-ZnO on DNA damage repair-related proteins and epithelial mesenchymal transition (EMT) by Western blotting. Then, CRISPR/cas9-based technique was used to create p53 knockout (p53-KO) cell line. RNA-seq analysis was performed to uncover the circular RNA (circRNA) profile after Nano-ZnO treatment in p53-KO cells compared with p53 wild-type (p53-wt) cells. LC–MS/MS was used to discover the potential binding proteins of circRNA_0085439 in the p53 deficiency background after Nano-ZnO treatment. Nano-ZnO-induced DNA damage and EMT were also investigated in vivo by instillation of Nano-ZnO (50 µg/mouse).

Results
Nano-ZnO exposure caused DNA damage and EMT at both in vitro and in vivo background, which was reflected by increased DNA damage associated proteins such as ATM and ATR and γ H2AX. p53 expression increased at the early stage post Nano-ZnO treatment decreased later. RNA-seq assay showed a highest increase of circRNA_0085439 expression in p53-KO cells compared with the p53-wt cells after Nano-ZnO exposure. Silencing of p53 expression promoted its translocation of circRNA_0085439 from cytoplasm to nucleus leading to the formation of circRNA_0085439/Ku70 complex resulting in the decreased expression of Ku70 protein. In addition, increased EMT markers, N-cadherin and Vimentin, was observed in lung epithelial cells and in mouse lungs at day 7 after Nano-ZnO exposure.

Conclusions
This study unraveled the epigenetic mechanisms underlying Nano-ZnO-induced DNA damage and EMT. The effect of Nano-ZnO-induced DNA damage through p53/circRNA_0085439/Ku70 pathway likely contribute to Nano-ZnO-induced cell cytotoxicity and apoptosis. Our findings will provide information to further elucidate the molecular mechanisms of Nano-ZnO-induced cytotoxicity and genotoxicity.
Two birds with one stone: triple negative breast cancer therapy by PtCo bimetallic nanozyme coated with gemcitabine-hyaluronic acid-polyethylene glycol
Authors: Sharifi Majid , Kheradmandi Rasoul , Alizadeh Morteza 
Published: April 2023

AbstractFor the treatment of triple-negative breast cancer (TNBC), without expression of estrogen, progesterone and HER2 receptors, specific treatment guideline is still under criticism, especially in tumor hypoxia. But assuming the molecular similarity of TNBC with breast cancer gene-1-related cancers, gemcitabine may be used in TNBC treatment on the nanozyme platform combined with photodynamic therapy (PDT). After designing the nanozyme with four components, platinum–cobalt: with catalase/peroxidase capabilities, hyaluronic acid: nanozyme targeting by interacting with CD44 receptor, poly[ethylene glycol]: water-soluble macromolecule for immune escape, and Gem: antitumor drug, its physicochemical properties was investigated by thermogravimetric, X-ray diffraction and energy dispersive X-ray, and therapeutic effects in in vitro and in vivo. The results show that platinum–cobalt@gemcitabine-hyaluronic acid-polyethylene glycol (PtCo@Gem-HA-PEG) especially synergized with PDT has high toxicity on 4T1 cells and tumor by enhancing the catalase-/peroxidase-like activities to produce O2, O2•− and •OH, and increase the intracellular free radicals. PtCo@Gem-HA-PEG inhibits tumor development by increasing drug accumulation in the tumor and enhancing apoptotic mechanisms through synergistic activity with PDT. Nevertheless, the major organ damage confirmed by the histological method in the long-term application of PtCo@Gem-HA-PEG, makes their application challenging due to permanent catalytic activity. However, results of improved drug permeability based on reduced hypoxia, higher drug retention, and enzyme-like activity that could be synergized with other therapeutic approaches like a PDT, have made their use attractive. Hence, this study provides a promising path in the TNBC treatment by nanozymes, which requires further toxicological investigations.
Graphic Abstract