bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electropatterning—Contemporary developments for selective particle arrangements employing electrokinetics
Authors: Lomeli‐Martin Adrian , Ahamed Nuzhet , Abhyankar Vinay V. , Lapizco‐Encinas Blanca H. 
Published: April 2023

AbstractThe selective positioning and arrangement of distinct types of multiscale particles can be used in numerous applications in microfluidics, including integrated circuits, sensors and biochips. Electrokinetic (EK) techniques offer an extensive range of options for label‐free manipulation and patterning of colloidal particles by exploiting the intrinsic electrical properties of the target of interest. EK‐based techniques have been widely implemented in many recent studies, and various methodologies and microfluidic device designs have been developed to achieve patterning two‐ and three‐dimensional (3D) patterned structures. This review provides an overview of the progress in electropatterning research during the last 5 years in the microfluidics arena. This article discusses the advances in the electropatterning of colloids, droplets, synthetic particles, cells, and gels. Each subsection analyzes the manipulation of the particles of interest via EK techniques such as electrophoresis and dielectrophoresis. The conclusions summarize recent advances and provide an outlook on the future of electropatterning in various fields of application, especially those with 3D arrangements as their end goal.
The impact of Disability Insurance reassessment on healthcare use
Authors: Badji Samia , Kavanagh Anne , Petrie Dennis 
Published: April 2023

AbstractSeveral Organisation for Economic Co‐operation and Development countries have constrained Disability Income Insurance (DI) eligibility and reassessed those on DI to encourage workforce participation. But these policies can also have unintended consequences. While receiving less income can directly worsen physical and mental health, the stress related to reassessment and the possibility of losing DI may also adversely affect mental health. This paper uses Australian population‐wide administrative data to explore how a 2014 policy ‐ where DI recipients under 35 were reassessed under stricter criteria ‐ affected healthcare use. We exploit this age targeting using a difference‐in‐difference regression design and find that the policy increased nervous system drug prescriptions (which includes antidepressants). Our findings suggest that the reassessment of DI recipients, even without income loss, may have had a significant negative impact on their mental health. DI reassessment policies may have the unintended consequence of worsening mental health and this needs be considered when deciding if reassessment is worthwhile.
Oral cavity carcinoma in patients with and without a history of lichen planus: A comparative analysis
Authors: Iocca Oreste , Copelli Chiara , Rubattino Stefano , Sedran Luca , Di Maio Pasquale , Arduino Paolo Giacomo , Ramieri Guglielmo , Garzino‐Demo Paolo 
Published: April 2023

AbstractBackgroundOral potentially malignant disorders (OPMD) are associated with the risk of malignant transformation (MT) into oral cavity carcinoma (OCC). Oral lichen planus (OLP) is one of the most common OPMDs in western countries. Although there is a substantial amount of research on progression to cancer, a specific analysis of the clinical characteristics and prognosis of cancer developed in patients with a history of OLP versus patients without a history of OLP has not been investigated so far.MethodsRetrospective evaluation of 82 patients treated for OCC with a known history of OLP compared to a representative sample of 82 patients treated for OCC without a known history of LP. Comparative analyses were performed on age at presentation, sex, TNM staging, clinical characteristics, pathology characteristics, 2‐ and 5‐year overall survival (OS), and disease‐free survival (DFS).ResultsIt was shown that patients with a history of LP were significantly younger at first presentation than patients without a history of LP (mean age difference 6.7 years, 95% CI 3.1–10.3, p < 0.05). Also, patients with a history of OLP were in higher proportion females. The main pathological stage at presentation was significantly lower in the OLP group (p < 0.05). The 2‐year survival analysis showed that DFS and OS were significantly lower in patients without a known history of OLP, with a hazard ratio (HR) of 3.1 (95% CI 1.4–6.8) and HR of 2.6 (95% CI 1.3–5.3), respectively. The 5‐year survival analysis showed that DFS and OS were significantly lower in patients without a known history of OLP, with a hazard ratio of 3.1 (95% CI 1.6–6.2) and of 2.9 (95% CI 1.5–5.6), respectively.ConclusionsCancer arising from OLP has peculiar characteristics compared to cancer in naïve patients. It most commonly affects younger patients, women, and nonsmokers. It is usually diagnosed at earlier stages and appears to have less aggressive behavior at presentation. Moreover, when 2‐ and 5‐year survival is analyzed, it appears that patients in OLP group have an overall and a disease‐free survival advantage. These results suggest that cancer from OLP is less aggressive and thus has a potential biological difference with cancer arising in non‐OLP patients. Further clinical and basic investigations are needed to confirm the results of this study.
Four‐dimensional speckle tracking echocardiography and fragmented QRS in detection of early left ventricular systolic dysfunction in patients with subclinical hyperthyroidism
Authors: Karaca Yücel , Karasu Mehdi , Taşolar Hakan , Evren Bahri 
Published: April 2023

AbstractBackgroundThyroid disorders are associated with many cardiovascular risk factors. The importance of thyroid hormones in the pathophysiology of heart failure is underlined by the European guidelines of the European Society of Cardiology. However, the role of subclinical hyperthyroidism (SCH) in subclinical left ventricular (LV) systolic dysfunction is not entirely clear.MethodsThis cross‐sectional study included 56 SCH patients and 40 healthy volunteers. The 56 SCH group was divided into two subgroups depending on the presence of fragmented QRS (fQRS). In both groups, left ventricular global area strain (LV‐GAS), global radial strain (GRS), global longitudinal strain (GLS), and global circumferential strain (GCS) were obtained with four‐dimensional (4D) echocardiography.ResultsGAS, GRS, GLS, and GCS values were significantly different in SCH patients and in healthy volunteers. GLS and GAS values were lower in the fQRS+ than in the fQRS− group (−17.06 ± 1.00 vs. −19.08 ± 1.71, p < .001, and −26.61 ± 2.38 vs. −30.61 ± 2.57, p < .001, respectively). ProBNP was positively correlated with LV‐GLS (r = 0.278, p = .006) and LV‐GAS (r = 0.357, p < .001). Multiple linear regression analysis showed that fQRS was an independent predictor of LV‐GAS.Conclusions4D strain echocardiography may be helpful for the prediction of early cardiac dysfunction in patients with SCH. The presence of fQRS may be an indicator of subclinical LV dysfunction in SCH.
Spatiotemporal characteristics of high winds in Jilin Province during 1982–2021
Authors: Wei Xiao , Li Kaiwei , Zhao Yunmeng , Yang Yueting , Rong Guangzhi , Guo Ying , Zhang Jiquan 
Published: April 2023

AbstractHigh winds are a type of catastrophic weather characterized by wind speeds over 10.8 m·s−1, occurring in all seasons, and have become more frequent, impacting crop growth, agricultural production and quality of life. It is crucial to understand the spatial and temporal distribution patterns of high winds, as well as their speed and other characteristics, for logical planning of agricultural production and the creation of disaster resilience measures. This study applied the climate tendency, accumulative anomalies, theory of run, Mann–Kendall trend and Theil–Sen median to analyse the spatial and temporal distribution characteristics of the average wind speed and high wind days in Jilin Province, the probability of occurrence of high winds of various magnitudes in different eras, and the gale concentration degree (GCD) throughout Jilin Province for a total of 40 years from 1982 to 2021. The average wind speed and number of high wind days in Jilin Province have decreased over the past 40 years, and this trend has slowed over time. The average GCD in Jilin Province has shown an increasing trend over the last 40 years, with the average GCD being highest in Liouhe and lowest in Linjiang. In general, level six high winds were the main wind hazard level in Jilin Province, with the highest frequency occurring in different seasons and decades. In addition, the occurrence of high wind days is affected by global climate change and different underlying surfaces, which leads to maize and yield reduction. Research on the spatiotemporal distribution of high winds can provide important suggestions for the prevention and management of high wind disasters.
TiO2‐graphene dispersed sulfonated polyphenylenesulfide sulfone nanocomposites for medium temperaturePEMFCs
Authors: Theerthagiri Senthil , Krishnan Srinivasan , Deivanayagam Paradesi , Muthiah Chandran , Kannaiyan Dinakaran 
Published: April 2023

AbstractSulfonated polyphenylene sulphide sulfone (sPPSS) loaded with titania‐graphene (TiO2‐GNS) was synthesized by the polycondensation method and studied their suitability towards proton exchange membrane fuel cell applications. The structural, morphological, and physic‐chemical properties of sPPSS nanocomposites containing varying amounts of (1%, 2%, 3%, and 5%) TiO2‐GNS was investigated by Fourier transform infrared, H1‐NMR, P‐XRD, FE‐SEM, HR‐TEM, Raman spectrum, swelling ratio (SR), water uptake, thermal analysis, oxidative stability (OS) and proton conductivity. Further, the obtained TiO2‐GNS dispersed polymer membrane exhibits greatly reduced water absorption 4.44% and a less volume SR (15.6%). The 5 wt% TiO2‐GNS dispersed sPPSS nanocomposites exhibited a PC value around 2.03 × 10−2 S/cm at 110°C. The sPPSS nanocomposites membrane confirmed admirable OS with a maximum degradation of 39.15% during immersed in the Fenton reagent for 6 h at 80°C.
Formononetin improves the inflammatory response and bone destruction in knee joint lesions by regulating the NF‐kB and MAPK signaling pathways
Authors: Ni Kai‐nan , Ye Lin , Zhang Ye‐jin , Fang Jia‐wei , Yang Tao , Pan Wen‐zheng , Hu Xing‐yu , Lai He‐huan , Pan Bin , Lou Chao , He Deng‐wei 
Published: April 2023

AbstractFormononetin (FMN) is a phytoestrogen that belongs to the isoflavone family. It has antioxidant and anti‐inflammatory effects, as well as, many other biological activities. Existing evidence has aroused interest in its ability to protect against osteoarthritis (OA) and promote bone remodeling. To date, research on this topic has not been thorough and many issues remain controversial. Therefore, the purpose of our study was to explore the protective effect of FMN against knee injury and clarify the possible molecular mechanisms. We found that FMN inhibited osteoclast formation induced by receptor activator of NF‐κB ligand (RANKL). Inhibition of the phosphorylation and nuclear translocation of p65 in the NF‐κB signaling pathway plays a role in this effect. Similarly, during the inflammatory response of primary knee cartilage cells activated by IL‐1β, FMN inhibited the NF‐κB signaling pathway and the phosphorylation of the ERK and JNK proteins in the MAPK signaling pathway to suppress the inflammatory response. In addition, in vivo experiments showed that both low‐ and high‐dose FMN had a clear protective effect against knee injury in the DMM (destabilization of the medial meniscus) model, and the therapeutic effect of high‐dose FMN was stronger. In conclusion, these studies provide evidence of the protective effect of FMN against knee injury.
Bestandssicherung Luegbrücke – Absicherungsbauwerk unter altersschwacher Bestandsbrücke
Authors: Flatz Martin , Kirchmair Martin , Michl Thomas , Lechner Martin 
Published: April 2023

AbstractDie Luegbrücke ist mit einer Gesamtlänge von 1804 m die längste Brücke der Brennerautobahn A13. Sie wurde in den Jahren 1966–1968 erbaut und weist vier Tragwerkshauptfugen zwischen fünf konstruktiven Rahmentragwerken auf. Die Bauteile an den Fugen sind in einem schlechten Erhaltungszustand und nicht mehr sanierbar. Um die Verkehrssicherheit bis zur Inbetriebnahme des Ersatzneubaus sicherstellen zu können, wurden Absicherungskonstruktionen unter allen Tragwerksteilen realisiert, die an den vier Fugen liegen. Diese werden Bestandssicherung Luegbrücke genannt. Sie bestehen im Wesentlichen aus Stahlstützen und daraufliegenden Fachwerken, die unter den Bestand gebaut werden. Aufgrund der Steilheit und Unzugänglichkeit des Geländes wurden die Arbeiten soweit wie möglich von oben durchgeführt. Die 8,5 m hohen und 35 m langen Fachwerke wurden stehend mittels Sondertransport auf der Autobahn antransportiert und anschließend mittels Tandemhub auf den bereits vorbereiteten Stahlstützen und Querverschubbahnen abgelegt. Anschließend wurden die Fachwerke unter die Hauptträger der Bestandsbrücke gezogen und ausgesteift. Bei einem eventuellen Versagen der Spannbeton‐Bestandsbrücke legen sich das gesamte Eigengewicht und die gesamte Nutzlast auf die Bestandssicherungskonstruktion. Da der Spalt max. 20 mm beträgt, besteht zu keinem Zeitpunkt ein Absturzrisiko. Nach entsprechenden Anpassungsarbeiten kann die Luegbrücke voraussichtlich wieder eingeschränkt genutzt werden.
A Semiautomated Analysis of Displacement‐To‐Length Scaling of the Grabens Affecting Lunar Floor‐Fractured Craters
Authors: Luzzi Erica , Nodjoumi Giacomo , Massironi Matteo , Pozzobon Riccardo , Rossi Angelo Pio 
Published: April 2023

AbstractLunar floor‐fractured craters are characterized by the occurrence of radial and concentric grabens, and while their formation mechanism was broadly studied in literature, the relationships between displacement and length of the faults, together with the fault growth, were never examined. We produced a semiautomated Python‐based script able to analyze all the parameters required for this study: displacement, length, width of the grabens, and power law relationship between displacement and length. The results of our investigation, carried on in Komarov, Humboldt, and Atlas craters, showed a sublinear fault growth, suggesting that for some reason the increase in displacement is not linear with respect to length. This can result from the interplay of mechanical discontinuities related to the stratigraphy (which cause a vertical fault restriction, preventing the displacement from developing in depth), and to linkage phenomena. The Dmax/L ratios that resulted from our analyses are higher than previously predicted for the Moon and appear more similar to the values observed on Earth. The slip distribution revealed different stages of fault interaction within the same crater, while the overall maturity of the grabens seems to be significantly high based on the observed symmetry of the grabens. Moreover, our code (public and accessible) can facilitate future works that aim to widen our knowledge about the lunar faults' growth, with all the implications that can improve our understanding of the faults' behavior.
Impact of sex on prognosis in patients with advanced renal cell carcinoma treated with immune checkpoint inhibitors
Authors: Nemoto Yuki , Ishihara Hiroki , Nakamura Kazutaka , Tachibana Hidekazu , Fukuda Hironori , Yoshida Kazuhiko , Kobayashi Hirohito , Iizuka Junpei , Shimmura Hiroaki , Hashimoto Yasunobu , Kondo Tsunenori , Takagi Toshio 
Published: April 2023

Abstract

Background
Prognostic impact of sex in patients with malignancies treated with immune checkpoint inhibitors has been intensively discussed but remains unclear, especially in advanced renal cell carcinoma.

Methods
We retrospectively evaluated a total of 184 patients with advanced renal cell carcinoma treated with either nivolumab plus ipilimumab combined treatment as first-line therapy (n = 73) or nivolumab as later-line therapy (n = 111) at our affiliated institutions. Progression-free survival, overall survival and objective response rate as well as adverse event profile were compared between sexes.

Results
Of the total 184 patients, 48 (26%) were female. Female patients had a significantly shorter progression-free survival than male patients (median: 3.8 vs. 8.3 months, P = 0.0005), but overall survival (median: 39.2 vs. 45.1 months, P = 0.283) and objective response rate (29% vs. 42%, P = 0.119) were not different between them. Similar findings were observed when analyzing within each treatment; in both patient groups treated with nivolumab plus ipilimumab combined therapy and nivolumab monotherapy, progression-free survival was significantly shorter in female than in male patients (P = 0.007, P = 0.017), but overall survival (P = 0.914, P = 0.117) and objective response rate (P = 0.109, P = 0.465) were comparable between them. Moreover, in a more restricted cohort consisting of patients with clear-cell renal cell carcinoma, a shorter progression-free survival in female patients was also observed (3.8 vs. 11.0 months, P &lt; 0.0001).

Conclusions
This retrospective study showed that immune checkpoint inhibitors-based treatment for renal cell carcinoma exhibited less marked effects in female than in male patients. Thus, sex may be an important factor for decision-making on systemic therapy as renal cell carcinoma treatment, although further studies are required to validate the present findings.
RESUSCITATIVE RECTAL BALLOON COMPRESSION COMBINED WITH PELVIC BINDER EFFICIENTLY CONTROLLED FATAL VENOUS HEMORRHAGE IN A HEMODYNAMICALLY UNSTABLE PELVIC FRACTURE CANINE MODEL
Authors: Chu Qinjun , Jin Xiaogao , Bing Hailong , Zhang Chenxi , Bai Jingyue , Li Fang , Lou Junge , Sun Liwei , Lin Lin , Li Liumei , Wang Haibo , Zhou Zhanfeng , Lian Hongkai 
Published: April 2023

ABSTRACT

Objective: This study evaluated the feasibility of a combination of pelvic binder and rectal balloon compression in managing fatal venous hemorrhage in a canine model of pelvic fracture. Methods: Rectums from humans (rectal cancer patients), swine, and canines were retrieved to determine their elasticity by measuring their stress and strain. Canines were selected as the animal model in this study because their rectum demonstrated more reversible strain than swine rectum. Doppler ultrasound was used to assess the effect of rectal balloon volume on the blood flow of pelvic iliac blood vessels in three canines. A rectal balloon of 250 mL was chosen to control pelvic venous bleeding as it could provide a peak effect in reducing the blood flow of bilateral internal iliac veins. Then, the open-book pelvic fracture with fatal bleeding of both internal iliac veins animal model was built. The animals were divided into four groups after the modeled surgery to undergo no treatment, pelvic binder, rectal balloon compression, or a combination of pelvic binder and rectal balloon compression. The treatment efficacy was evaluated based on their survival time, survival rate, blood loss, bleeding rate, infusion rate, blood pH, lactate concentration, the stability of hemodynamics, blood loss, and fluid infusion volume. Results: Our results showed that after the reproducible injuries in both internal iliac veins, the combination of pelvic binder and rectal balloon compression was associated with the best survival rate and survival time compared with the other treatment groups. In addition, the combination of pelvic binder and rectal balloon compression exhibited more stable hemodynamics than the pelvic binder or rectal balloon compression treatment alone. Conclusions: This study demonstrated the potential feasibility of using pelvic binder combined with rectal balloon compression to manage the fatal venous bleeding in pelvic fractures.
Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience
Authors: Hegedüs Panna , Lyakhova Victoria , Velencei Anna , Mayer Márton I. , Zelenak Zsofia , Nyiri Gábor , Hangya Balázs 
Published: April 2023

AbstractParvalbumin (PV)-expressing GABAergic neurons of the basal forebrain (BFPVNs) were proposed to serve as a rapid and transient arousal system. While they have a well-documented role in the regulation of sleep-wake states, whether and how BFPVNs participate in mediating awake behaviors is not known. To address this, we performed bulk calcium imaging and recorded single neuronal activity from the horizontal band of the diagonal band of Broca (HDB) while mice were performing an associative learning task. Genetically identified BFPVNs of the HDB responded with a distinctive, phasic activation to punishment. In contrast, reward only elicited slow and delayed responses, while stimuli predicting behavioral reinforcement (reward or punishment) were followed by a gradual increase of HDB BFPVN firing rates. Optogenetic inhibition of HDB BFPVNs during punishment impaired the formation of cue-outcome associations, suggesting a causal role of these neurons in associative learning. Mapping the input-output connectivity of HDB BFPVNs by anterograde and mono-transsynaptic retrograde tracing experiments showed that these neurons received strong inputs from the hypothalamus, the septal complex and the median raphe region, while they synapsed on diverse cell types in key structures of the limbic system including the medial septum, the retrosplenial cortex and the hippocampus. Bulk calcium imaging performed in these termination regions indicated that HDB BFPVNs broadcast information about aversive stimuli to multiple downstream targets. We propose that the arousing effect of BFPVNs is recruited by aversive stimuli to serve crucial associative learning functions during awake behaviors.
The contemporary football industry: a value-based analysis of social, business structural and organisational stakeholders
Authors: Yiapanas George , Thrassou Alkis , Vrontis Demetris 
Published: April 2023

PurposeFootball exists and evolves in a dynamic ecosystem, displaying a massive and multidimensional influence on most contemporary societies, and football has grown into a significant industry with a plethora of stakeholders. This research is the first to comprehensively identify the key industry stakeholders and their distinct value, from the individual club perspective, and to conceptualise and test their interrelationship toward the development of a corresponding framework of club benefits.Design/methodology/approachThe study applied a multilevel approach to collect and verify qualitative data. It initially developed a preliminary conceptual framework, which was first validated by an expert panel and was subsequently extensively tested in the Cyprus-specific context, which offered fertile ground for such a study. The empirical stage rested on 41 semi-structured, face-to-face interviews with very high-ranking individuals from the top nine football clubs, as well as with key industry stakeholders.FindingsThough the examined industry is partly in line with international norms, it is also highly affected by unique characteristics that alter the various stakeholders' role, producing (even negative) value of varied typologies that is directly linked with the industry's financial, sporting, cultural and social conditions.Research limitations/implicationsThe research ultimately presents scholars, practitioners and policymakers with a systemic and comprehensive understanding of the individual club stakeholder value offerings, delivers a tested framework as a tool for social and business management and prescribes future avenues for research, governance and practice.Originality/valueExtant studies on the subject are either partial or focus on individual stakeholders and evidently lack requisite scientific comprehensiveness. The current research bridges this significant gap in knowledge by exhaustively identifying the key industry stakeholders, explicating their relative social, economic or other value in the individual club perspective and developing a value-based stakeholder framework.