bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ophthalmic viscoelastics commonly used in cataract surgery: A microbiota investigation
Authors: Dowler Kourtney K. , Vientós‐Plotts Aida , Giuliano Elizabeth A. , McAdams Zachary L. , Dorfmeyer Rebecca A. , Reinero Carol R. , Ericsson Aaron C. 
Published: February 2023

AbstractPurposeTo survey commonly used, sterile ophthalmic viscoelastic materials used during routine cataract surgery for the presence of bacterial DNA and/or viable bacteria and endotoxin quantification.MethodsSamples from three different ophthalmic viscoelastic manufacturers and three different production lots per manufacturer were collected for 16 S ribosomal ribonucleic acid (rRNA) sequencing and conventional aerobic and capnophilic bacterial culture. Other samples of viscoelastic material from the same three manufacturers were collected for endotoxin quantification using a commercially available Limulus amebocyte lysate (LAL) assay. Statistical analysis was performed using Sigma Plot 14.0, and R v4.0.2.0. Differences (p ≤ .05) between sample collection sites in total DNA concentration, microbial richness, mean intra‐group distances, and endotoxin quantification alongside reagent controls were evaluated.ResultsCulture yielded two isolates, identified as Staphylococcus epidermidis and Bacillus megaterium. 16 S rRNA sequencing revealed no differences between brands in richness or overall composition. The most common bacterial DNA detected across all brands was Staphylococcus sp., Cutibacterium sp., Flavobacterium sp., and Lactobacillus sp. A significant difference was found between the median endotoxin concentration between Anvision and Hyvisc® viscoelastic (Anvision: 0.171 EU/mL, Hyvisc®: 0.03 EU/mL; p < .001).ConclusionsNo brand‐specific differences in bacterial DNA were detected in the viscoelastic materials. Staphylococcus, Cutibacterium, Flavobacterium, and Lactobacillus were the dominant contributors to the bacterial DNA detected. Although Anvision viscoelastic samples contained significantly more endotoxin than Hyvisc® viscoelastic samples, endotoxin concentrations were below the FDA limit of 0.2 EU/mL for both manufacturers. These data further the understanding of inflammatory outcomes following cataract surgery.
One-to-One Correspondence of Soft and Hard Pomeron with the Color Dipole Picture of the Gluon Density at Low x
Authors: Boroun G. R. 
Published: February 2023

The correspondence between the gluon density behavior of the color dipole picture (CDP) and the two-Pomeron approach at low x deep inelastic scattering is considered. For photon virtualities of $${{Q}^{2}} \gtrsim 10$$ GeV2, the results for the parametrization and CDP models are defined by the CDP asymptotic limit and are compatible with the soft and hard-Pomeron approach. These results show that the hard-Pomeron trajectory does not guarantee converging towards the asymptotic representation at low and large $${{Q}^{2}}$$ ($${{Q}^{2}} \lesssim 100$$ GeV2) values in a wide range of the virtual-photon–proton energy squared. The gluon distributions can be obtained directly in terms of the proton structure functions and the running coupling and compared with the results from the M. Gluck, P. Jimenez-Delgado and E. Reya (GJR) and A. Martin, W. Stirling, R. Thorne, and G. Watt (MSTW) parametrizations.
Explaining the CDF-II W-boson mass anomaly in the Georgi–Machacek extension models
Authors: Du Xiao Kang , Li Zhuang , Wang Fei , Zhang Ying Kai 
Published: February 2023

AbstractOriginal Georgi–Machacek model can preserve the custodial symmetry at tree level after the electroweak symmetry breaking. Unless additional $$SU(2)_c$$

S
U

(
2
)

c

custodial symmetry breaking effects are significant, the new physics contributions to $$\Delta m_W$$

Δ

m
W

are always very small. Our numerical results show that ordinary GM model can contribute to $$\Delta m_W$$

Δ

m
W

a maximal amount 0.0012 GeV, which can not explain the new CDF-II anomaly on W boson mass. We propose firstly to introduce small misalignment among the triplet VEVs to increase $$\Delta m_W$$

Δ

m
W

, which can give large new physics contributions to $$\Delta m_W$$

Δ

m
W

. Such slightly misaligned triplet VEVs from custodial symmetry preserving scalar potential can still be allowed. Our numerical results indicate that the resulting $$\Delta m_W$$

Δ

m
W

can easily reach the $$1\sigma $$

1
σ

range of CDF-II $$m_W$$

m
W

data and the splitting among the triplet VEVs $$\Delta v$$

Δ
v

($$\equiv v_\xi -v_\chi $$

≡

v
ξ

-

v
χ

) can be as small as 0.8 GeV for $$v_\chi \lesssim 15$$

v
χ

≲
15

GeV. We also propose to introduce an additional custodial symmetry breaking source by extending the GM model with a low scale RH neutrino sector, which can adopt the leptogenesis mechanism and allow moderately large coupling strength $$h_{ij}$$

h

ij

even for triplet VEVs of order GeV. With low scale RH neutrino mass scale of order $$10^2$$

10
2

–$$10^4$$

10
4

TeV, the new physics contribution to $$\Delta m_W$$

Δ

m
W

can reach 0.03 GeV and is much larger than that of ordinary GM model. Combining both custodial $$SU(2)_c$$

S
U

(
2
)

c

symmetry breaking effects, the small misalignment among the triplet VEVs and the moderately large $$h_{ij}$$

h

ij

couplings allowed with RH neutrino sector, the value of $$\Delta m_W$$

Δ

m
W

can still easily reach the $$1\sigma $$

1
σ

range of CDF-II $$m_W$$

m
W

data, with a minimum splitting (among the triplet VEVs) approximately 0.7 GeV for $$v_\chi \lesssim 15$$

v
χ

≲
15

GeV.
Polarization compensation method based on the wave plate group in phase mismatch for free-space quantum key distribution
Authors: Tan Yongjian , Zhang Liang , Sun Tianxing , Song Zhihua , Wu Jincai , He Zhiping 
Published: February 2023

AbstractMaintaining the polarization state in communication terminals is vital for polarization-encoding free-space quantum key distribution (QKD). Wave plate group phase mismatch caused by manufacturing errors, complex environmental effects, and the working wavelength deviation can reduce the polarization compensation effect. We found in theoretical analysis, that increasing phase mismatch of wave plates leads to the compensation method failure and reduces robustness. We propose a complementary polarization compensation method, which can effectively improve the robustness. Experimental results show that this method can improve the compensation effect by 50% at a slight phase mismatch, and realize a polarization extinction ratio exceeding 250:1 at the ergodic area even if the phase deviates to 0.27π. This method is beneficial to the high-stability design of free-space QKD systems and has the potential to be applied to QKD systems operating at multiple wavelengths.
Preliminary Test of Gas Wave Ejector in Coalbed Methane Well Site and Impact Analysis of Fluid Medium Characteristics on Its Pressure Port Design
Authors: Zhao Yiming , Hu Dapeng , Yu Yang , Li Haoran , Feng Qing 
Published: February 2023

Gas wave ejector (GWE) is an efficient energy conversion device which can recover and utilize excess pressure energy of high pressure fluid. It has significant application value in the sustainable development of energy resources, including the exploitation and transportation of natural gas. The first practical application test of GWE in the natural gas industry is completed in this study. The mechanisms and regulations of the effect of actual gas properties on the pressure port design of GWE were also investigated. The primary conclusions are as follows: the composition of working medium significantly affects the propagation velocity of pressure waves. The wave propagation velocity increases as methane purity (φCH4) rises. The equipment efficiency was decreased by up to 23% of the optimal value as a result of the variation in port position brought on by the increase in φCH4 from 0.7 to 1.0. The variation of working pressure ratio has a greater impact on the device performance than the pressure value when the pressure port design kept unchanged. The intake temperature fluctuation in the range of -30°C to 50°C has no obvious influence on the ideal port design. In the coal-bed methane well site industrial test, GWE accomplishes a recovery of low-pressure well by roughly

8.83
×

10

3

N

m

3

/
d

, demonstrating its excellent ejection capacity. In addition, the variable speed test conducted under different working conditions shows that the equipment performance can be effectively enhanced by adjusting the rotation speed as the equipment structure remains unchanged with the changing working pressure/pressure ratio. In the field test range of this study, the increase of equipment ejection rate obtained by speed adjustment can rise up to 12% of the corresponding value at the designed rotation speed.
Association Between Recreational Physical Activity and mTOR Signaling Pathway Protein Expression in Breast Tumor Tissue
Authors: Cheng Ting-Yuan David , Zhang Runzhi , Gong Zhihong , Qin Bo , Cannioto Rikki A. , Datta Susmita , Zhang Weizhou , Omilian Angela R. , Yao Song , Khoury Thaer , Hong Chi-Chen , Bandera Elisa V. , Ambrosone Christine B. 
Published: February 2023

Physical activity (PA) is associated with decreased signaling in the mTOR pathway in animal models of mammary cancer, which may indicate favorable outcomes. We examined the association between PA and protein expression in the mTOR signaling pathway in breast tumor tissue. Data on 739 patients with breast cancer, among which 125 patients had adjacent-normal tissue, with tumor expression for mTOR, phosphorylated (p)-mTOR, p-AKT, and p-P70S6K were analyzed. Self-reported recreational PA levels during the year prior to diagnosis were classified using the Centers for Disease Control and Prevention guideline as sufficient (for moderate or vigorous) PA or insufficient PA (any PA but not meeting the guideline) or no PA. We performed linear models for mTOR protein and two-part gamma hurdle models for phosphorylated proteins. Overall, 34.8% of women reported sufficient PA; 14.2%, insufficient PA; 51.0%, no PA. Sufficient (vs. no) PA was associated with higher expression for p-P70S6K [35.8% increase; 95% confidence interval (CI), 2.6–80.2] and total phosphoprotein (28.5% increase; 95% CI, 5.8–56.3) among tumors with positive expression. In analyses stratified by PA intensity, sufficient versus no vigorous PA was also associated with higher expression levels of mTOR (beta = 17.7; 95% CI, 1.1–34.3) and total phosphoprotein (28.6% higher; 95% CI, 1.4–65.0 among women with positive expression) in tumors. The study found that guideline-concordant PA levels were associated with increased mTOR signaling pathway activity in breast tumors. Studying PA in relation to mTOR signaling in humans may need to consider the complexity of the behavioral and biological factors.Significance:PA increases energy expenditure and limits energy utilization in the cell, which can influence the mTOR pathway that is central to sensing energy influx and regulating cell growth. We studied exercise-mediated mTOR pathway activities in breast tumor and adjacent-normal tissue. Despite the discrepancies between animal and human data and the limitations of our approach, the findings provide a foundation to study the mechanisms of PA and their clinical implications.
Stroke Thrombectomy in the Elderly: Efficacy, Safety, and Special Considerations
Authors: Chen Huanwen , Jindal Gaurav , Miller Timothy R. , Gandhi Dheeraj , Chaturvedi Seemant 
Published: February 2023

Background
Elderly patients account for a major Q2 proportion of ischemic strokes worldwide, and the use of endovascular thrombectomy (EVT) for the elderly has been increasing in recent years. Major clinical trials have demonstrated the benefit of EVT for the general population; however, the degree of benefit is less clear in elderly populations. Although EVT is generally considered safe and effective in healthy elderly adults, there remains controversy as to whether EVT should be offered to all elderly patients, and optimal patient selection and management strategies remain elusive.

Methods
This review consolidates the current literature on the overall efficacy and safety of EVT in the elderly population and highlights multiple topics that are particularly relevant to elderly populations.

Results/Conclusions
Topics discussed include quality of life, patient selection strategies, white matter disease burden, reperfusion of large ischemic cores, bridging thrombolysis, prethrombectomy imaging, as well as technical considerations.
Source-Aware Embedding Training on Heterogeneous Information Networks
Authors: Chan Tsai Hor , Wong Chi Ho , Shen Jiajun , Yin Guosheng 
Published: February 2023

ABSTRACT
Heterogeneous information networks (HINs) have been extensively applied to real-world tasks, such as recommendation systems, social networks, and citation networks. While existing HIN representation learning methods can effectively learn the semantic and structural features in the network, little awareness was given to the distribution discrepancy of subgraphs within a single HIN. However, we find that ignoring such distribution discrepancy among subgraphs from multiple sources would hinder the effectiveness of graph embedding learning algorithms. This motivates us to propose SUMSHINE (Scalable Unsupervised Multi-Source Heterogeneous Information Network Embedding)—a scalable unsupervised framework to align the embedding distributions among multiple sources of an HIN. Experimental results on real-world datasets in a variety of downstream tasks validate the performance of our method over the state-of-the-art heterogeneous information network embedding algorithms.
Evaluation and Projection of Changes in Daily Maximum Wind Speed over China Based on CMIP6
Authors: Zha Jinlin , Shen Cheng , Wu Jian , Zhao Deming , Fan Wenxuan , Jiang Huiping , Zhao Tianbao 
Published: February 2023

Abstract
Future changes in spatiotemporal features of the mean wind speed over China have been extensively reported, but future changes in the maximum wind speed, such as the daily maximum wind speed (DMWS), were rarely estimated. In this study, the performance of Coupled Model Intercomparison Project phase 6 (CMIP6) models in simulating the DMWS changes across China is evaluated, based on which the projection on DMWS is carried out under different shared socioeconomic pathways (SSPs). The observed DMWS shows a significant reduction during all four seasons, with the strongest decrease in spring and the weakest decrease in autumn. The DMWS increases from January to April and decreases from April to August. The spatiotemporal characteristics of the DMWS are captured by the multimodel ensemble of CMIP6; however, the reduction of DMWS in CMIP6 is weaker than those in observations. The performance of CMIP6 in simulating the future DMWS changes over China shows regional and seasonal discrepancies. The projected DMWS exhibits a reduction for all SSPs from 2021 to 2100, and the decreasing trend is increased accompanied by the strength in the forcing scenario. The lower-emission scenario likely avoids the long-term weakening of the DMWS. The effects of strength in forcing scenarios on the trends of DMWS are more significant than the DMWS climate state. The seasonal cycle of the projected DMWS under the different SSPs is consistent with the historical DMWS; however, the strength in the forcing scenario could induce enhanced variability in the month-to-month DMWS difference.

Significance Statement
Estimation and projection of daily maximum wind speed (DMWS) are crucial for many socioeconomic and environmental issues, as DMWS can induce damage to buildings and infrastructure and affect the air quality and frequency of dust storms, among many other aspects. Nevertheless, future changes in the DMWS have rarely been investigated in China. This paper suggests that the lower forcing scenario could effectively avoid the long-term reduction in DMWS. The seasonal cycle of the future DMWS is consistent with the historical DMWS; however, the stronger forcing scenario induces the strengthening of the month-to-month wind speed difference variability. This study provides a scientific basis for decision-makers to formulate policies to deal with climate change.
Quantitative effects of bilirubin structural photoisomers on the measurement of direct bilirubin via the vanadate oxidation method
Authors: Arioka Makoto , Koyano Kosuke , Nakao Yasuhiro , Ozaki Miyo , Nakamura Shinji , Kiuchi Hiroyuki , Okada Hitoshi , Itoh Susumu , Murao Koji , Kusaka Takashi 
Published: February 2023

Background Exposing blood serum samples to ambient white light-emitting diode (WLED) light may accelerate bilirubin photoisomer production. We previously demonstrated the quantitative effect of bilirubin configurational isomers (BCI) on direct bilirubin (DB) value using the vanadate oxidation method. However, the effects of bilirubin structural photoisomers (BSI) remain unclear. Methods In Study 1, the relationship between WLED irradiation time and BSI production was examined. Serum samples from five neonates were irradiated with WLED light for 0, 10, 30, 60 and 180 min. Bilirubin isomer concentration and BSI production rates were calculated. In Study 2, we performed quantitative investigation of BSI effect on DB values: Differences in DB, BCI and BSI values before and after irradiation were calculated as ⊿DB, ⊿BCI and ⊿BSI, respectively. Assuming the coefficient of BCI affecting DB values was ‘ a’, relational expression was ⊿DB = a*⊿BSI + 0.19*⊿BCI. Serum samples from 15 neonates were irradiated with green LED light for 10 and 30 s. The respective bilirubin isomer levels were measured, and the coefficient was derived. Results In Study 1, the median BSI production rate was 0.022 mg/dL per min in specimens with an unconjugated bilirubin concentration of 10.88 mg/dL. In Study 2, assuming that ⊿DB-0.19*⊿BCI was Y and ⊿BSI was X, the relational expression was Y = 0.34 X-0.03 ( R2 = 0.87; p < .01) and a = 0.34. Conclusions Under ambient WLED light, serum sample generated 1.3 mg/dL BSIs in 1 h. Approximately 34% (0.44 mg/dL) of BSI concentrations was measured as DB when using the vanadate oxidation method according to the above equation.
The association of hyperhomocysteinemia with acute post-operative complications following coronary artery bypass grafting
Authors: Panicker Bipin Thomas , Veerapudran Sivaprasad , Damodaran Deepthi , Thomas Ronnie , Krishnan Jayakumar Thanathu 
Published: February 2023

Background Hyperhomocysteinemia is associated with an increased risk for cardiovascular diseases. The influence of hyperhomocysteinemia on post-operative events, after coronary artery bypass surgery graft, is less studied. Methods This cross-sectional study aimed to determine if hyperhomocysteinemia was associated with post-operative complications in patients < 50 years who underwent off-pump coronary artery bypass graft for coronary artery disease. A set of major post-operative complications were considered as primary outcome measures. The independent effect of hyperhomocysteinemia and other risk factors in the incidence of post-operative complications was determined by multivariate analysis. Results The mean homocysteine levels among the study participants who had post-operative complications were significantly higher than those without post-operative complications (17.37 mmol/L vs. 12.84 mmol/L). On multivariate analysis, hyperhomocysteinemia, diabetes mellitus, and higher body mass index (> 25) were significant predictors of adverse events during the post-operative period. Conclusion Hyperhomocysteinemia was a significant predictor of immediate post-operative adverse events after coronary artery bypass surgery graft. Necessary precautions and management strategies have to be evolved for these high-risk subsets.
Associations of antidepressants and antipsychotics with lipid parameters: Do CYP2C19/CYP2D6 genes play a role? A UK population-based study
Authors: Richards-Belle Alvin , Austin-Zimmerman Isabelle , Wang Baihan , Zartaloudi Eirini , Cotic Marius , Gracie Caitlin , Saadullah Khani Noushin , Wannasuphoprasit Yanisa , Wronska Marta , Dawda Yogita , Osborn David PJ , Bramon Elvira 
Published: February 2023

Background: Dyslipidaemia is an important cardiovascular risk factor for people with severe mental illness, contributing to premature mortality. The link between antipsychotics and dyslipidaemia is well established, while evidence on antidepressants is mixed. Aims: To investigate if antidepressant/antipsychotic use was associated with lipid parameters in UK Biobank participants and if CYP2C19 and CYP2D6 genetic variation plays a role. Methods: Review of self-reported prescription medications identified participants taking antidepressants/antipsychotics. Total, low-, and high-density lipoprotein cholesterol (L/HDL-C) and triglycerides derived from blood samples. CYP2C19 and CYP2D6 metabolic phenotypes were assigned from genetic data. Linear regression investigated aims, adjusted for key covariates. Results: Of 469,739 participants, 36,043 took antidepressants (53% female, median age 58, 17% taking cholesterol-lowering medications) and 3255 took antipsychotics (58% female, median age 57, 27% taking cholesterol-lowering medications). Significant associations were found between use of each amitriptyline, fluoxetine, citalopram/escitalopram, sertraline, paroxetine and venlafaxine with higher total cholesterol, LDL-C, and triglycerides and lower HDL-C, compared to participants not taking each medication. Venlafaxine was associated with the worst lipid profile (total cholesterol, adjusted mean difference: 0.21 mmol/L, 95% confidence interval (CI): 0.17 to 0.26, p < 0.001). Antipsychotic use was significantly associated with lower HDL-C and higher triglycerides. In participants taking sertraline, CYP2C19 intermediate metabolisers had higher HDL-C (0.05 mmol/L, 95% CI: 0.01 to 0.09, p = 0.007) and lower triglycerides (−0.17 mmol/L, 95% CI: −0.29 to −0.05, p = 0.007), compared to normal metabolisers. Conclusions: Antidepressants were significantly associated with adverse lipid profiles, potentially warranting baseline and regular monitoring. Further research should investigate the mechanistic pathways underlying the protective effects of the CYP2C19 intermediate metaboliser phenotype on HDL-C and triglycerides in people taking sertraline.
Implementation effect of a hierarchical pharmaceutical service pattern in patients with systemic lupus erythematosus
Authors: Gong Yinhua , Wei Wei , Zhang Wei , Han Qiang , Zhang Chunge 
Published: February 2023

Objectives This study evaluated the effect of implementing a hierarchical pharmaceutical service pattern based on the knowledge–attitude–practice (KAP) intervention theory on patients with systemic lupus erythematosus. Methods Eligible patients were randomly divided into an intervention or control group. Pharmaceutical service classification criteria were formulated and used to provide patients with differing levels of pharmaceutical services. The classification scores and KAP levels of patients before and at various time points after the intervention were analyzed. The rates of acute attacks and adverse reactions, related clinical test indices, and disease activity were evaluated in both groups. Results After 9 months of intervention, the proportions of first- and second-level services in the intervention group declined by 14.43% and 3.94%, respectively, compared with the control group, and the rates of acute attacks and adverse reactions declined by 18.26% and 12.43%, respectively. The KAP level, clinical test indices, and disease activity were significantly different between the groups. Conclusion Providing patients with systemic lupus erythematosus with pertinent hierarchical pharmaceutical services based on the KAP theory was instrumental in changing patients’ behavior and contributed to facilitating disease self-management, thus improving the quality of pharmaceutical services.