bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wastewater-based SARS-CoV-2 airport surveillance: key trends at the Cape Town International Airport
Authors: Nkambule Sizwe , Johnson Rabia , Mathee Angela , Mahlangeni Nomfundo , Webster Candice , Horn Suranie , Mangwana Noluxabiso , Dias Stephanie , Sharma Jyoti Rajan , Ramharack Pritika , Louw Johan , Reddy Tarylee , Surujlal-Naicker Swastika , Mdhluli Mongezi , Gray Glenda , Muller Christo , Street Renee 
Published: March 2023

Abstract
Monitoring of SARS-CoV-2 RNA in wastewater has revealed the role of mobility in the transmission of coronavirus disease (COVID-19), and the surveillance of airport wastewater in cities across the world has demonstrated how travel entry points can give an indication of trends in transmission. This study undertook wastewater surveillance at the Cape Town International Airport (CTIA) to assess the use of a WBE approach to provide supplementary information on the presence of COVID-19 at a key air travel entry point in South Africa. Grab wastewater samples (n = 55) were collected from the CTIA wastewater pump station and analysed using quantitative real-time polymerase chain reaction (qRT-PCR) method. The study found a correlation between the wastewater data and clinical cases reported in the City of Cape Town during various time periods and during the peak of a COVID-19 wave. Highly elevated viral loads in the wastewater were observed at times there was increased mobility through the airport. The study also revealed elevated viral load levels at the airport despite the stricter restrictions and through the lower restrictions. The study findings indicate wastewater surveillance and airports can provide supplementary information to airport authorities to assess the impacts of imposed travel restrictions.
What Cannot Be Deconstructed? Truth
Authors: Kozak Piotr 
Published: March 2023

In this paper, I discuss the interpretation of the method of deconstruction in David J. Gunkel’s Deconstruction (MIT Press 2021). I focus on the relationship between deconstruction and truth. I hold that the concept of truth is indispensable for deconstruction since truth introduces correctness conditions for the deconstructive method. However, I claim that truth, being essential and primitive for deconstruction, is fundamentally inaccessible for being analyzed by the latter.
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Received: 19/10/2022. Reviewed: 13/12/2022. Accepted: 20/12/2022.
Cationic Ruthenium for C-H Activation Reactions
Authors: Purohit Priyank 
Published: March 2023

Abstract:
C-C bond formation in a regiospecific and atom economic manner has been a challenge,
which was tried to be resolved through directing group and organometals-based C-H
activation strategy. The C-H activation and its advantages are well explored in the field of
organic chemistry, with the relevant mechanistic approach of the regioselective C-H activation
of the aryl group. Organometals like Ru, Pd, Pt, Ni, etc. have been best discovered for the
innate C-H activation where the pre-activation of the inert C-H bond was not found necessary.
In the progress of these reactions through organometals, the various forms of ruthenium have
been tried with the different directing groups as well as the substrate. Here in we are focusing
mainly on cationic ruthenium, and its use in the C-H activation. The cationic ruthenium
shows unique characteristics like reactivity with an inert substrate, which is been highlighted
here in the examples. The formation and its, mechanistic role is also exemplified with the diagrammed representation
of C-H activation and its catalytic cycle. The application of the cationic ruthenium will give complete
knowledge about cationic ruthenium and its application in C-H activation.
Chemistry of Thieno[2,3-c]quinoline Derivatives Part (VII), Reactivities, and Biological Activities
Authors: Gouda Moustafa A. , Alansari Rayan M. , Abu-Hashem Ameen A. , El-Gazzar Abdel-Rahman B.A. , Abdelgawad Ahmed A.M. , Salem Mohammed A. 
Published: March 2023

Abstract:
In this review, numerous thieno[2,3-c]quinoline derivatives (TQs2, 3-c) are presented from
a variety of angles, including various preparation and processing techniques, using cutting-edge
equipment. Numerous chemical processes in this review demonstrate how (TQs2, 3-c) were made
from arylamines, ketones, aldehydes, carboxylic acids, and other chemical reagents. The amidation,
tandem C-C and C-N bond creation accelerated by palladium, Vilsmeier reaction, and Pictet-Spengler
chemical reactions were used to shed light on how (TQs2, 3-c) was made.
Current Advances in Wound Healing and Regenerative Medicine
Authors: Fani Nesa , Moradi Maryam , Zavari Roxana , Parvizpour Farzad , Soltani Adele , Arabpour Zohreh , Jafarian Arefeh 
Published: March 2023

Abstract:
Treating chronic wounds is a common and costly challenge worldwide. More advanced treatments
are needed to improve wound healing and prevent severe complications such as infection and amputation.
Like other medical fields, there have been advances in new technologies promoting wound healing
potential.

:
Regenerative medicine as a new method has aroused hope in treating chronic wounds. The technology
improving wound healing includes using customizable matrices based on synthetic and natural polymers,
different types of autologous and allogeneic cells at different differentiation phases, small molecules,
peptides, and proteins as a growth factor, RNA interference, and gene therapy. In the last decade, various
types of wound dressings have been designed. Emerging dressings include a variety of interactive/
bioactive dressings and tissue-engineering skin options. However, there is still no suitable and effective
dressing to treat all chronic wounds.

:
This article reviews different wounds and common treatments, advanced technologies and wound dressings,
the advanced wound care market, and some interactive/bioactive wound dressings in the market.
Anlotinib Inhibits Proliferation and Induces Apoptosis in B-cell Acute Lymphoblastic
Leukemia by Targeting the BTK and AKT/mTOR Pathway
Authors: Shi Xiaowei , Li Shuangyue , Tang Shanhao , Lu Ying 
Published: March 2023

Background:
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults,
whose known drug treatments are limited and expensive.

Objective:
This investigation aimed to investigate the therapeutic potential of anlotinib in B-cell acute lymphoblastic
leukemia (B-ALL).

Methods:
The B-ALL cell lines Nalm-6 and BALL-1 were used to verify the therapeutic potential of anlotinib in BALL.
The cell activity was measured by Cell Counting Kit-8. Apoptosis was detected by Annexin V-FITC/PI double
staining combined with flow cytometry. Afterward, the binding capacity of anlotinib to the critical protein was predicted
by molecular docking, and the protein changes in the related pathways downstream of the target proteins were verified
by western blot. Finally, the effect of anlotinib on the survival rate was verified in B-ALL nude mice.

Results:
Anlotinib inhibited the proliferation of the B-ALL cell lines, Nalm-6, and BALL-1, and promoted apoptosis.
Molecular docking results showed that it had the potential binding ability to BTK. Western blot revealed that anlotinib
was able to inhibit the phosphorylation of BTK, AKT, and mTOR, thereby inhibiting the proliferation of B-ALL cells.
In addition, anlotinib suppressed weight loss and prolonged the survival time of mice.

Conclusion:
To summarize, anlotinib can inhibit the proliferation of B-ALL and promotes apoptosis by inhibiting the
phosphorylation of BTK and AKT, and mTOR.
Pharmacology, Ethnopharmacology, and Phytochemistry of Medicinally
Active Moringa oleifera: A Review
Authors: Kumar Nitin , Sharma Shikha 
Published: March 2023

Abstract:
Moringa oleifera (MO), which belongs to the family Moringaceae, is a significant medicinal
plant that is also one of the species farmed in the greatest quantity worldwide. All its components, including
its leaves, roots, seeds, flowers, bark, stems, and green pods, have a wide range of medicinal properties
and are exceptionally high in nutritional content. Some of the important medicinal properties of the
plant include anticancer, antiasthmatic, antipyretic, antiepileptic, anti-inflammatory, antiulcerative, cholesterol-
lowering, antioxidant, antidiabetic, hepatoprotective, diuretic, CNS depressant, antibacterial, antifungal,
anthelmintic, antibiotic, analgesic, antimalarial, antispasmodic, etc. Its nutritional value is attributed
to the presence of proteins, carbohydrates, minerals, vitamins, amino acids, α-carotene, and various
phenolic compounds. The purpose of this review is to present a synopsis of the ethnobotany, nutritive,
and phytochemical profiles of various parts as well as the pharmacological properties of MO, with a particular
emphasis on the several processes that are responsible for its multispectral activity. Additionally, it
highlights studies on the safety profile, medication interactions, and relevant clinical trials. MO is used in
pharmaceutics as an active extract in metallic nanoparticles and as an excipient in different pharmaceutical
products. Other applications related to its water-purifying features, such as biodiesel, biogas, and biopesticide,
are also discussed in the present article. Thus, the review provides necessary information proving
that each part of MO has beneficial effects, and the plant can be studied extensively for many research
aspects.
A Comprehensive Review on the Anti-inflammatory Activity of Chalconesderived
Moieties
Authors: Mittal Roopal , Sharma Shailesh , Kushwah Ajay Singh , Yaqoob Obaid , Kumari Deepika 
Published: March 2023

Background:
In recent decades, all-embracing research accounting for thousands of natural
bioactive compounds have been detailed on behalf of their origin, pharmacological activity, active
phytoconstituents, and therapeutic applications. Chalcones, secondary metabolites have shown
therapeutic potential against various forms of inflammation, pain, and cancer in multiple research
papers targeting their pathway inhibition and their significant therapeutic activity.

Area Covered:
Diverse aspects of chalcones have been focused on with their biological source,
pathway inhibition, and pharmacological activity.

Objectives:
This study aims to focus on the chalcones being the origin of ethnopharmacological, possess
extensive pharmacological activities, including anti-neoplastic, antimicrobial, anti-inflammatory,
antioxidant, anti-acne, anti-aging, hepatoprotective, neuroprotective, psychoactive, anti-parasitic,
and many others.

Method:
Chalcones display anti-inflammatory activity via COX-2, NO synthase, and TNF-α inhibition.
Furthermore, comprehensive studies will be discussed with a viewpoint of the chalcones’s role
in the alleviation of inflammation. According to recent advancements, chalcones clinically have been
used in the treatment of inflammation, anti-aging, oxidative stress reduction, autophagy, and apoptosis.

Conclusion:
This article focuses on the molecular progression of inflammation and the chalcone role in combating inflammation by targeting inflammatory mediators and pathways.
Pengenalan Tanda Arah untuk Navigasi Automatic Guided Vehicle berbasis Raspberry Pi
Authors: Florentinus Budi Setiawan  , Rachmat Hidayat  , Leonardus Heru Pratomo  , Slamet Riyadi  
Published: March 2023

Perkembangan zaman modern di sektor teknologi robotika dan mekanisasi telah meningkat sangat signifikan dalam beberapa dekade ini karena efisiensinya yang tinggi dari aspek waktu dan tenaga. Pada sistem mobilisasi barang untuk pemanfaatan perusahaan, khususnya bagian industri dan bagian pergudangan, salah satu robot yang digunakan adalah kendaraan berpemandu otomatis pengangkut barang atau yang biasa disebut sebagai automatic guided vehicle (AGV). Salah satu metode navigasi lama di AGV adalah penggunaan sebuah sensor untuk mengikuti pola garis pada objek yang terdeteksi, yaitu garis pada lantai. Metode tersebut kurang efektif karena lambat laun objek pola garis di lantai tersebut akan menghilang akibat efek dari gaya gesek roda AGV, sehingga tidak lagi dapat terdeteksi oleh sensor kamera. Oleh sebab itu, diperlukan sebuah peningkatan metode navigasi AGV agar dapat menjadi sebuah inovasi yang berkelanjutan. Metode navigasi ini menggunakan empat objek gambar yang diposisikan pada area yang dilintasi robot AGV dan kamera sebagai sensor yang menghadap ke depan, sehingga AGV dapat dengan presisi mendeteksi pola objek gambar menggunakan bantuan computer vision menggunakan library perangkat lunak OpenCV. Selanjutnya, pola objek gambar yang sudah terdeteksi diproses oleh sebuah program yang dirancang pada perangkat komputer mini Raspberry Pi 4 Model B. Hasil pengujian membuktikan bahwa metode ini mampu mendeteksi objek gambar yang berada di area yang terjangkau kamera dan berhasil menampilkan keluaran dari objek gambar tersebut. Sistem berhasil mengenali objek secara cukup akurat, dengan parameter jarak 10–95 cm dan melalui beberapa percobaan. Analisis kecepatan putaran roda depan dan belakang AGV dilakukan menggunakan osiloskop dan takometer sebagai alat pengukur kecepatan atau rotasi roda.
Pengaturan Posisi Sudut Motor DC menggunakan Proporsional Integral (PI) Control untuk Kicker Robot Sepak Bola Beroda
Authors: Hais Yosi Riduas , Saputra Oki , Zahidarrifqi Mhd. 
Published: March 2023

Penendang (kicker) merupakan suatu komponen pada robot sepak bola beroda yang berfungsi untuk menendang bola. Kicker dapat dibangun dengan berbagai cara, salah satunya dengan memanfaatkan motor DC. Untuk menghasilkan tendangan yang kuat dan stabil diperlukan prime mover berupa dua motor DC yang di-couple. Penerapan strategi ini menimbulkan masalah berupa sulitnya sikronisasi kedua motor DC tersebut. Penelitian ini difokuskan pada penerapan PI control untuk pengaturan posisi sudut kicker pada dua motor DC PG45. Didapatkan hasil bahwa kicker mampu mencapai posisi 45o, 56o, 75o dan 91o dengan error steady state yang dihasilkan sebesar 1o pada posisi 55o dan 90o serta kelajuan tendangan rata – rata masing – masing parameter sebesar 21,323 m/s, 43,422 m/s, 5,169 m/s dan 4,032 m/s.
Prototype Sistem Pendeteksi Objek Mobil pada Lampu Lalu Lintas Menggunakan Metode Blob Detection
Authors: Aulia Ursi , Fuady Samratul , Hais Yosi Riduas 
Published: March 2023

Perkembangan sistem ketenagalistrikan semakin pesat sejalan dengan pengembangan energi baru terbarukan. Intermittent menjadi masalah utama pembangkit listrik terbarukan, sehingga penggunaan baterai menjadi solusi. Namun hal ini justru menghasilkan limbah bahan beracun dan berbahaya sehingga tujuan untuk menciptakan energi bersih tidak dapat tercapai. Pengembangan photovoltaic (PV) dengan sistem grid tied dapat menjadi solusi dari masalah tersebut. Manfaat dari penggunanaan PV dengan sistem grid tied adalah konsumen dapat menyuplai daya di kondisi daya berlebih dan digantikan pada malam hari sehingga ada pemotongan dari pembayaran listrik setiap bulannya. Dengan begitu, teknologi penyimpanan tidak lagi digunakan pada sistem ini dan terjadi dampak posisitif dari sisi ekonomi pada konsumen. Penelitian ini menganalisis aliran daya sebelum dan sesudah penggunaan PV pada beban home area network dan menghitung dampak ekonomi pada konsumen setelah menyuplai listrik pada grid utiliti.
(Synthetic) Data-driven identification of governing equations of aseismic/seismic fault slip and frictional heterogeneities
Authors: Biswas Pulak , Ray Sohom 
Published: March 2023

Models of fault slip development generally consider interfacial strength
to be frictional and deformation of the bounding medium to be elastic.
The frictional strength is usually considered as sliding rate- and
state-dependent. Their combination, elastic deformation due to
differential slip and rate-state frictional strength, leads to nonlinear
partial differential equations (PDEs) that govern the spatio-temporal
evolution of slip. Here, we investigate how data on fault slip rate and
stress can directly discover the complex system (of PDEs) that
governs aseismic slip development. We first prepare (synthetic) data
sets by numerically solving the forward problem of slip rate and fault
stress evolution with models, such as a thin laterally deformable layer
over a thick substrate. We now identify the variables, for example, slip
rate or friction state variable, and use nonlinearity
identification algorithms to discover the governing PDE of the chosen
variable.
In particular, we use sparse identification of nonlinear dynamics
algorithm (SINDy, Brunton et al., 2016) where we solve a regression
problem, Ax=y. Here, y is the time derivative of the
variable of interest, for example, slip rate. A is a large
matrix (library) with all possible candidate functions that may appear
in the slip rate evolution PDE. The entries in x, to be solved
for, are coefficients corresponding to each library function in matrix
A. We update A according to the solutions x
so that A’s column space can span the dynamics we seek to find.
To find the suitable column space for A, we encourage
sparse solutions for x, suggesting that only a few
columns in matrix A are dominant, leading to a
parsimonious representation of the governing PDE.
We show that the algorithm successfully recovers the terms of the PDE
governing fault slip and could also find the frictional parameter, for
example, a/b, where a and b, respectively, are the magnitudes that
control direct and evolution effects. Moreover, the algorithm can also
determine whether the associated state variable evolves as aging- or
slip-law types or their combination. Further, with the data set prepared
from distinct initial conditions, we show that the SINDy can also
determine the problem parameter’s spatial distribution
(heterogeneities) from fault slip rate and stress data.
Tirzepatide reduces appetite, energy intake and fat mass in people with T2D
Authors: Heise Tim , Hans DeVries J , Urva Shweta , Li Jing , Pratt Edward J. , K. Thomas Melissa , Mather Kieren J. , A. Karanikas Chrisanthi , Dunn Julia , Haupt Axel , Milicevic Zvonko , Coskun Tamer 
Published: March 2023

<p> </p>
<p><strong>OBJECTIVE</strong>: To evaluate effects of tirzepatide on body composition, appetite and energy intake to address the potential mechanisms involved in body weight loss with tirzepatide.</p>
<p><strong>RESEARCH DESIGN AND METHODS</strong>: In a secondary analysis of a randomized, double-blind, parallel-arm study, the effects of tirzepatide 15 mg (N=45), semaglutide 1 mg (N=44) and placebo (N=28) on body weight and composition, appetite, and energy intake were assessed at baseline and Week 28.</p>
<p><strong>RESULTS</strong>: Tirzepatide treatment demonstrated significant reductions in body weight compared to placebo and semaglutide, resulting in greater fat mass reduction. Tirzepatide and semaglutide significantly reduced appetite vs placebo. Appetite scores and energy intake reductions did not differ between tirzepatide and semaglutide. </p>
<p><strong>CONCLUSIONS</strong>: Differences in energy intake during <em>ad libitum </em>lunch were not sufficient to explain the different weight outcomes. Further evaluation is needed to assess mechanistic differences related to tirzepatide actions on 24-hour energy intake, substrate utilization and energy expenditure.</p>
Development of welding discontinuity identification system using statistical texture feature extraction and ANN classification on digital radiographic image
Authors: Ahmadi Haerul , Arifian Dandi , Mulyono Tasih , Pribadi Bangun , Rachmanita Risse Entikaria 
Published: March 2023

Discontinuity in welds is one of the causes of the quality of a connection in the material decreases function. Undamaged test with radiographic method is one of the tests to see the quality of a weld. The test results are radiograph images and evaluated by a radiographer. So this research is designed by optimizing a system to help the work of a radiography expert in identifying discontinuities by utilizing the Matlab Application. On this system uses the method of characteristic extraction and classification of neural networks (AAN). The system uses a characteristic extraction method with geometric invariant moment (GIM) algorithms and a gray level co-occurenece matrix (GLCM) as identification values used in the classification process. The calcification process uses a backpropagation-type multilayer Artificial Neural Network. The types of discontinuities used as data in this system are incompleted of penetration, crack, wormhole, and distributed porosity using a total of 800 datasets of radiograph imagery data. This data sharing is organized using k fold cross validation. The study conducted 15 experiments in system testing to prove the truth in identifying. The results of the experiment resulted in the highest average performance score reaching 93.33%
Behavior of Pile Group Constructed on Clayey Soil under El-Centro Seismic
Authors: Afnan H. Ali  , O. Abbas Hassan , Abd Safa H. , Mohamed Sreh Muftah 
Published: March 2023

Over the past decades, pile foundations used to support buildings through a transfer of superstructure loads into more stable soil strata than surface soil layers. Buildings are exposed to seismic force, pile undergoes more stress through the significant vibration of the surrounding soil in addition to the static stresses of buildings. The investigation of the behavior of pile foundations under the influence of earthquakes is still limited or not well described. Further, this paper presents a theoretical study to evaluate the vertical settlement and horizontal displacement of piles embedded in clay and silty soil of Baqubah soil under the effect of the acceleration time history of the 1940 El-Centro earthquake. The study was carried out by using the commercial finite element software PLAXIS 3D. A three-dimensional analysis of the soil-pile foundation for four multi-story buildings is performed with different diameters (0.5, 0.7, and 1) m for the corner, exterior, and interior pile, respectively. The linear elastic model for pile foundation and the Mohr-Coulomb model for soil layers were used in this numerical analysis. The research showed that vertical settlement and horizontal displacement increase as the duration of the earthquake increases, and horizontal displacement with values smaller than vertical displacement. Also, the results showed the vertical settlement is similar for different diameters, in contrast to the horizontal displacement, which was of different values with a range between (3% to 22%) when the diameter increased from 0.5m, 0.7m, and 1m. Also, it can be observed that values increased with the direction of the earthquake from the right to the left side of the pile-soil system with a range of (12% to 32%).
Murottal Qur'an Psychotherapy on Breast Cancer Survivors in South Sulawesi
Authors: Azriful Azriful , Wahyuddin Wahyuddin , Jusriani Rini 
Published: March 2023

Indonesia is ranked 8th in Southeast Asia with a high cancer incidence, with a breast cancer proportion of 16.7%. Chemotherapy, which is usually done, has side effects and stress for breast cancer survivors, so a solution that has minimal side effects and is easy to do is needed. This study aims to assess the effect of murottal Qur'an psychotherapy on breast cancer survivors in South Sulawesi. This study was qualitative with a phenomenological study approach. The key informants were breast cancer survivors who were Think Survive Cancer Woman Support Group community members. Data were collected through observation, in-depth interviews, and documentation by triangulating sources, methods, and times. The reinforcing factor for doing murottal Al-Qur'an psychotherapy is family support, especially from husbands, health workers' support, and the support of fellow survivors. Through murottal Al Qur'an, the self-acceptance of survivors to carry out their duties and obligations as wives and mothers of their children become better. Murottal Al-Qur'an Psychotherapy positively impacts the stress level of breast cancer survivors. Murottal Al-Qur'an psychotherapy provides a sense of calm for breast cancer survivors so that it has a positive effect in reducing stress.