bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Helicobacter heilmannii Gastritis in a Patient With Human Immunodeficiency Virus
Authors: Granger Madison , Knights Sheena 
Published: August 2023

Abstract

Helicobacter heilmannii is an uncommon Helicobacter that is a cause of gastritis in humans similar to Helicobacter pylori (H. pylori). Treatment of H. heilmannii is not well studied, but traditional H. pylori regimens have shown success in case reports. Most case reports are in immunocompetent hosts, so little is known about the interplay between H. heilmannii and the immune system. We report a case of H. heilmannii infection in a patient with well-controlled human immunodeficiency virus infection who was treated with quadruple therapy (tetracycline, metronidazole, bismuth, and proton pump inhibitor) and had successful eradication of his infection.
Prolonged Epstein-Barr Virus DNA Detection in a Case of Infantile Infectious Mononucleosis
Authors: Sato Masayuki , Nagamori Tsunehisa , Izumi Kengo , Takahashi Hironori , Manabe Hiromi , Taketazu Genya , Shirai Masaru 
Published: August 2023

Abstract
Infectious mononucleosis (IM) caused by Epstein-Barr virus (EBV) is a relatively common disease in adolescents and children. There have been few reports on serial changes in EBV DNA load in IM infants, and we herein describe the precise clinical course as well as the kinetics of EBV DNA load in a case of infantile IM. An 11-month-old girl presented with persistent fever, splenomegaly, and rash and was diagnosed with IM on the basis of her EBV DNA load despite the absence of a significant increase in anti–viral capsid antigen-IgM. The result of a cytomegalovirus antigenemia assay was also positive during the acute phase, but this quickly changed to negative. However, despite the spontaneous resolution of symptoms and seroconversion, the EBV DNA load result remained positive for more than 1 year. Although the potential impact from cytomegalovirus infection is uncertain, we speculate that prolonged EBV DNA load may occur in immunocompetent infantile IM patients.
Retrospective Review of Periurethral Lymph Node Dissection in Clinically Localized Prostate Cancer
Authors: Holdren Charla , Pulford Christopher , Keating Kevin , Peifer David , Eames Richard , Wisnewski Samuel , Maatman Thomas 
Published: August 2023

Abstract

Purpose:
The purpose of this study was to evaluate the prevalence of positive periurethral lymph nodes during robotic-assisted radical prostatectomy (RARP) and to investigate the relationship between secondary end points of tumor staging, PSA, and Gleason score.

Materials and Methods:
This study is a retrospective review of 1177 RARPs performed from October 2011 to February 2022. Using pathology reports, the study population was condensed to 58 patients who had periurethral lymph node tissue. This population was then analyzed for the prevalence of malignant tissue in the specimen. A secondary analysis was performed for data on PSA, Gleason score (preoperative and postoperative), and tumor-nodes-metastases (TNM) staging.

Results:
Retrospective analysis demonstrated 9 of 58 specimens (15.5%) to be positive for malignancy. There was a statistically significant (P < .004) correlation between lymph node status and PSA. The average PSA was 17.60 (SD = 15.54) for those with positive periurethral lymph nodes and 7.96 (SD = 6.65) for those with negative periurethral lymph nodes. There was no statistically significant association between lymph node status and preoperative Gleason scores. There was, however, a statistically significant difference across lymph node status and postoperative Gleason scores (X2 (3) = 11.09, P = .01).

Conclusion:
Positive periurethral lymph nodes demonstrated higher average PSAs, postoperative Gleason scores, and TNM staging. Further analysis is required to evaluate potential prognostic implications.
Skincare from the inside out: a pilot project addressing social determinants of health through dermatology
Authors: Kimball Kelly M. , Cowan Rachael A. , Krevh Rachel , Nicholson Adrianna , Shah Payas , Gurumurthy Shreya , Graham Jacqueline 
Published: August 2023

Background:
Many women’s shelters across the nation have programs that emphasize and empower women through career workshops and skills training. However, what is not typically addressed is their dermatological and mental health needs, which are equally important.

Objective:
Through this pilot project, we aim to address the diverse interrelated issues concerning the whole woman and her body/mind systems including skin cancer awareness, skincare, healthy sun habits, self-esteem, mental health, and stress management. By addressing the woman holistically, we hope to positively impact the way she views and values herself.

Methods:
We partnered with a local women’s shelter to host a seminar focused on dermatological and mental health education. Pre- and post-seminar surveys were collected from participants. Surveys were anonymous and aimed to evaluate the success and efficiency of the workshop to guide and improve future seminars. The seminar had three workshops: skin cancer and sun protection, skincare, and mental health and wellness. Upon completion of the seminar, the attendees were provided with the opportunity to receive free skin examinations by two board-certified dermatologists, and referrals were made to Northeast Ohio Medical University’s Student-Run Free Clinic. Upon completion of the seminar, attendees were provided with items such as sunscreen, skincare, and mental health resources.

Results:
The “Skincare from the Inside Out” pilot project proved to be beneficial to residents of both Norma Herr Women’s Shelter.

Limitations:
Limitations of this study were the small sample size (n = 15), due to participation limitations during the COVID-19 pandemic.

Conclusion:
Ultimately, to reduce the morbidity and mortality of dermatologic conditions associated with homelessness, it is imperative to address upstream social determinants of health. Future development of this pilot project will aim toward educating medical professionals on the unique and complex dermatologic and mental health needs of women experiencing homelessness.
HbA1c/C-peptide ratio is associated with angiographic thrombus burden and short-term mortality in patients presenting with ST-elevation myocardial infarction
Authors: Toprak Kenan , Kaplangöray Mustafa , Memioğlu Tolga , İnanir Mehmet , Omar Bahadir , Taşcanov Mustafa Beğenç , Biçer Asuman , Demirbağ Recep 
Published: August 2023

ObjectivesAngiographic high thrombus burden (HTB) is associated with increased adverse cardiovascular events in patients with ST-elevation myocardial infarction (STEMI). HbA1c and C-peptide are two interrelated bioactive markers that affect many cardiovascular pathways. HbA1c exhibits prothrombogenic properties, while C-peptide, in contrast, exhibits antithrombogenic effects. In this study, we aimed to demonstrate the value of combining these two biomarkers in a single fraction in predicting HTB and short-term mortality in patients with STEMI.Methods1202 patients who underwent primary percutaneous coronary intervention (pPCI) for STEMI were retrospectively included in this study. The study population was divided into thrombus burden (TB) groups and compared in terms of basic clinical demographics, laboratory parameters and HbA1c/C-peptide ratios (HCR). In addition, short-term mortality of the study population was compared according to HCR and TB categories.ResultsHCR values were significantly higher in the HTB group than in the LTB group (3.5 ± 1.2 vs. 2.0 ± 1.1;P < 0.001; respectively). In the multivariable regression analysis, HCR was determined as an independent predictor of HTB both as a continuous variable [odds ratio (OR): 2.377; confidence interval (CI): 2.090–2.704;P < 0.001] and as a categorical variable (OR: 5.492; CI: 4.115–7.331;P < 0.001). In the receiver operating characteristic (ROC) analysis, HCR predicted HTB with 73% sensitivity and 72% specificity, and furthermore, HCR's predictive value for HTB was superior to HbA1c and C-peptide. The Kaplan-Meier cumulative survival curve showed that short-term mortality increased at HTB. In addition, HCR strongly predicted short-term mortality in Cox regression analysis.ConclusionsIn conclusion, HCR is closely associated with HTB and short-term mortality in STEMI patients.
Association of single nucleotide polymorphisms (4G/5G) of plasminogen activator inhibitor-1 and the risk factors for placenta-related obstetric complications
Authors: Donmez Hanife Guler , Beksac Mehmet Sinan 
Published: August 2023

Background
Placenta-related obstetric complications (PROCs) such as miscarriage, fetal growth restriction, preeclampsia, and preterm birth are the major causes of maternal and fetal morbidity and mortality. The objective of this study was to search the relevance of plasminogen activator inhibitor-1 (PAI-1) polymorphisms and co-morbidities and the risk factors for PROCs such as miscarriage, fetal growth restriction, preeclampsia, and preterm birth.

Method
This retrospective study analyzed the PAI-1 genotype in a cohort of 268 multiparous women with poor obstetric history. Poor obstetric history was defined as the presence of at least one of the PROCs and/or poor gestational outcomes at the previous pregnancy/pregnancies.

Results
5G allele frequency was higher than the 4G allele frequency in the cohort (0.767 vs. 0.233). The frequencies of having at least one risk factor are relatively similar among the different PAI-1 genotypes (P > 0.05). However, the presence of MTHFR polymorphisms (homozygous and compound heterozygous forms of C677T and A1298G) and hereditary thrombophilia (Factor V Leiden and prothrombin G20210A gene mutations, and FXIII deficiency) were found to be associated with PAI 4G/4G (P = 0.048) and 5G/5G (P = 0.022) genotypes, respectively. Significant differences were not observed in other risk factors and co-morbidities such as autoimmune disorders, chronic inflammatory diseases, history of venous thromboembolism, carbohydrate metabolism disorders, hyperlipidemia, cardiovascular and cerebrovascular diseases depending on PAI-1 genotypes (P > 0.05).

Conclusion

MTHFR polymorphisms were found to be associated with PAI 4G/4G genotype, while 5G/5G genotype was observed more frequently in hereditary thrombophilia cases.
Mechanisms relating to sleeping position to the endotypes of sleep disordered breathing
Authors: Messineo Ludovico , Joosten Simon , Perger Elisa 
Published: August 2023

Purpose
Obstructive sleep apnea (OSA) severity varies considerably depending on the body position during sleep in certain subjects. Such variability may be underpinned by specific, body position-related changes in OSA pathophysiological determinants, or endotypes. Also head position relative to trunk may influence OSA endotypes. However, no studies to our knowledge have reviewed the endotype variations according to head or body position up to now.

Recent findings
Several findings illustrate that supine OSA is mostly attributable to unfavorable upper airway anatomy compared to lateral position. However, a reduced lung volume, with consequent ventilatory instability (or elevated loop gain), may also play a role. Furthermore, preliminary findings suggest that prone and reclined positions may have a beneficial effect on collapsibility and loop gain.

Summary
Sleeping supine induces many unfavorable pathophysiological changes, especially in certain predisposed OSA patients. Little is known on the influence of other sleep positions on key endotypic traits.
Unresectable hepatocellular carcinoma at dawn of immunotherapy era: real-world data from the French prospective CHIEF cohort
Authors: Nguyen-Khac Eric , Nahon Pierre , Ganry Olivier , Ben Khadhra Hajer , Merle Philippe , Amaddeo Giuliana , Ganne-Carrie Nathalie , Silvain Christine , Peron Jean-Marie , Mathurin Philippe , Anty Rodolphe , Uguen Thomas , Decaens Thomas , Riachi Ghassan , Bouattour Mohamed , Baron Aurore , Bronowicki Jean-Pierre , Pageaux Georges-Philippe , Rosmorduc Olivier , Ducournau Gérard , Gilberg Mélina , Tanang Alexandre , Dupin Julien , Gilbert-Marceau Anika , Blanc Jean-Frédéric ,   for the French CHIEF cohort group
Published: August 2023

Background and objectives
Hepatocellular carcinoma epidemiological data are limited in France. The Epidemio Liver Immunotherapy Tecentriq outcome research (ELITor) retrospective study, based on real-world data from the Carcinome HépatocellulaIrE en France (CHIEF) French cohort of hepatocellular carcinoma patients, aimed to get insight into the treatment patterns, the sociodemographic, clinical, biological, and etiological characteristics, and the quality of life of patients with unresectable hepatocellular carcinoma.

Methods and results
Between 1 September 2019 and 4 December 2020, 367 patients from the CHIEF cohort received at least one locoregional (52.8%) chemoembolization or radioembolization or systemic treatment (88.3%) and were selected for ELITor. Most patients had a Barcelona Clinic Liver Cancer (BCLC) C (93.2%) hepatocellular carcinoma stage and were affected by cirrhosis (67.7%). Alcohol was confirmed as the main etiology both as a single etiology (29.1%) and in association with other risk factors (26.9%), mainly metabolic disorders (16.2%).
Tyrosine-kinase inhibitors, mainly sorafenib, were the most administered systemic treatments in first line. Patients who received at least one combination of atezolizumab and bevacizumab during the study period (N = 53) had a better performance status and less portal hypertension frequency than the overall population and more hepatitis B virus infection and fewer metabolic disorders as single etiology. Overall, the global health score before treatment (62.3 ± 21.9) was in line with that of reference cancer patients and worsened in 51.9% of the cases after first-line palliative-intent treatment.

Conclusion
This study provided real-life data on advanced hepatocellular carcinoma characteristics and treatment patterns and described the first patients to receive the atezolizumab-bevacizumab combination before it became the new standard of care for advanced hepatocellular carcinoma.
Clinical course and prognosis of patients with hepatocellular carcinoma and haemophilia
Authors: Matsuda Noritaka , Imai Norihiro , Yokoyama Shinya , Yamamoto Kenta , Ito Takanori , Ishizu Yoji , Honda Takashi , Okamoto Shuichi , Kanematsu Takeshi , Suzuki Nobuaki , Matsushita Tadashi , Ishigami Masatoshi , Kawashima Hiroki 
Published: August 2023

Introduction
Although patients with haemophilia are known to develop hepatocellular carcinoma (HCC) at a lower age than patients without, there are few reports on the clinical course and prognosis of HCC.

Aim
We aimed to investigate the clinical course and prognosis of patients with HCC and haemophilia.

Methods
Twenty-two patients with haemophilia, who were initially diagnosed with HCC between 2003 and 2021, were included. Their clinical courses and prognoses were retrospectively analysed. The results were compared with those of the 24th Nationwide Follow-up Survey of Primary Liver Cancer.

Results
All 22 patients were male; of these, 20 patients had haemophilia A, and 2 had haemophilia B. The mean age of diagnosis was 63 years (range 45–78 years) which is lower than the mean of 72 years reported in the Nationwide Survey. The mean diameter of the largest tumour was 30 mm (range 11–70 mm), and 18 tumours (82%) were solitary at the initial diagnosis. Standard treatments for HCC were performed in all patients. Sixty-one transarterial chemoembolisation, 28 RFA, 10 hepatectomies, and 2 radiation treatments were performed, and molecular-targeted agents were administered to 5 patients during their clinical courses. No deaths were associated with complications of HCC treatments. The median survival time after initial treatment was 6.4 years (range 0.9–18.7 years) which did not differ much from the median survival time of 5.8 years in the Nationwide Survey.

Conclusion
Standard treatment for HCC could improve the prognosis of patients with HCC and haemophilia.
The number of hepatocellular carcinoma foci as predictor of poor response to tumor-directed therapies in patients awaiting liver transplantation: a prospective cohort study
Authors: Aydin Yucel , Koksal Ali R. , Thevenot Paul , Nunez Kelley , Elgamal Mohamed , Koksal Ulkuhan I. , Sandow Tyler , Moehlen Martin , Regenstein Frederic , Tahan Veysel , Cohen Ari 
Published: August 2023

Background and aims
Tumor-directed therapies (TDTs) are a constitutive part of hepatocellular carcinoma (HCC) treatment in patients awaiting liver transplantation (LT). While most patients benefit from TDTs as a bridge to LT, some patients drop out from the waiting list due to tumor progression. The study aimed to determine the risk factors for poor treatment outcome following TDTs among patients with HCC awaiting LT.

Methods
A total of 123 patients with HCC were evaluated with 92 patients meeting Milan Criteria enrolled in the prospective cohort study. Tumor response was evaluated using the modified Response Evaluation Criteria for Solid Tumors for HCC 1 month after the procedure. The risk factors for progressive disease (PD) and dropout were evaluated.

Results
After TDT, 55 patients (59.8%) achieved complete or partial response (44.6% and 15.2% respectively), 17 patients (18.5%) had stable disease, and 20 patients (21.7%) were assessed as PD. Multivariate analysis revealed a significant and independent association between the number of HCC foci and PD (P = 0.03, OR = 2.68). There was no statistically significant association between treatment response and demographics, MELDNa score, pre-and post-treatment alpha-fetoprotein (AFP), cumulative tumor burden the largest tumor size, or TDT modality. PD was the major cause of dropout in our cohort. Pre-treatment AFP levels ≥200 ng/ml had a strong association with dropout after TDTs (P = 0.0005).

Conclusion
This study demonstrated the presence of multifocal HCC is the sole prognostic factor for PD following TDTs in HCC patients awaiting LT. We recommend prioritizing patients with multifocal HCC within Milan criteria by exception points for LT to improve the dropout rate.
A radiomics nomogram based on 18F-FDG PET/CT and clinical risk factors for the prediction of peritoneal metastasis in gastric cancer
Authors: Xie Jiageng , Xue Beihui , Bian Shuying , Ji Xiaowei , Lin Jie , Zheng Xiangwu , Tang Kun 
Published: August 2023

Purpose
Peritoneal metastasis (PM) is usually considered an incurable factor of gastric cancer (GC) and not fit for surgery. The aim of this study is to develop and validate an 18F-FDG PET/CT-derived radiomics model combining with clinical risk factors for predicting PM of GC.

Method
In this retrospective study, 410 GC patients (PM − = 281, PM + = 129) who underwent preoperative 18F-FDG PET/CT images from January 2015 to October 2021 were analyzed. The patients were randomly divided into a training cohort (n = 288) and a validation cohort (n = 122). The maximum relevance and minimum redundancy (mRMR) and the least shrinkage and selection operator method were applied to select feature. Multivariable logistic regression analysis was preformed to develop the predicting model. Discrimination, calibration, and clinical usefulness were used to evaluate the performance of the nomogram.

Result
Fourteen radiomics feature parameters were selected to construct radiomics model. The area under the curve (AUC) of the radiomics model were 0.86 [95% confidence interval (CI), 0.81–0.90] in the training cohort and 0.85 (95% CI, 0.78–0.92) in the validation cohort. After multivariable logistic regression, peritoneal effusion, mean standardized uptake value (SUVmean), carbohydrate antigen 125 (CA125) and radiomics signature showed statistically significant differences between different PM status patients(P < 0.05). They were chosen to construct the comprehensive predicting model which showed a performance with an AUC of 0.92 (95% CI, 0.89–0.95) in the training cohort and 0.92 (95% CI, 0.86–0.98) in the validation cohort, respectively.

Conclusion
The nomogram based on 18F-FDG PET/CT radiomics features and clinical risk factors can be potentially applied in individualized treatment strategy-making for GC patients before the surgery.
Evaluation of the correlation between Altmetric attention score and citation number of top 50 articles in hip fractures: a cross-sectional study
Authors: Fallah Yousef , Soleimani Mohammad , Shafiei Seyyed Hossein , Pishkuhi Mahin Ahmadi 
Published: August 2023

Background:
Publications quality evaluation gets more attention nowadays, because of its impact on researchers ranking and academic journals. Beside traditional bibliometric tools, altemetric metrics have been introduced as tools to evaluate the dissemination of a study by the number of views, mentions, and posts on different websites and social medias.

Method:
In this study, the authors evaluate the correlation between citation number as a traditional tool and altmetric attention score (AAS) as a new method. Scopus database was searched to find the 50 most cited manuscripts on “hip fractures” title from January 2015 to December 2020. After excluding irrelevant subjects, AAS of included articles was collected from the Altmetric.com website. At the last stage, the data were analyzed using statistical tests.

Results:
According to statistical analysis, R
2 was 0.121, and the P-value was 0.017, which shows a weak but statistically significant relationship between citation and AAS. The relationship between the number of mentions on Twitter and the AAS was linear.
The differences observed between the two groups were significant only in “Readers on Mendeley” and “Dimensions”. Results shown that the impact factor of the journal and the AAS of articles had no significant relationship (R
2=0.001, P-value=0.986).

Conclusion:
Findings showed that social media does not seem to be ineffective in disseminating published articles. It has also been shown that Twitter can play a significant role in the propagation of articles on social networks. It is not unreasonable to say that the accessibility of a journal affects the dissemination of an article on social media. In the end, the authors found that the impact factor of the journal could not significantly affect the AAS.
Ectopic primary ductal breast carcinoma of the vulva: a case report and literature review
Authors: Mansour Marah , Zahra Orgwan , Nabulsi Dalia , Alhamwi Aya , Chahin Maya , alani Wael Raghid , Yousef Diaa , Kanbour Ilda , Kurdi Bashar , Mohammad Deeb Ahmad 
Published: August 2023

Background:
Ectopic breast tissue (EBT) is normally found along the rudimentary mammary line, which is located from the axilla to the inguinal region and disappears during embryogenesis. Up to 6% of females around the world suffer from EBT. EBT cancer is rare, with only a few reports in the literature. The diagnosis, and treatment of these rare cases can be very difficult and complex.

Case presentation:
The authors report an interesting case of a 74-year-old female patient with a vulvar lump located on the mons pubis associated with ulceration, pain, and size increase. The histopathological study demonstrated an invasive ductal carcinoma grade 2 arising from EBT in the vulva. Within 4 months of follow-up, the patient’s condition was stable.

Clinical discussion and conclusions:
Throughout this paper, the authors aim to highlight the diagnostic and therapeutic challenges since there are no current guidelines for treatment for such cases. Furthermore, this article describes this rare disease and includes surgical details, difficulties, diagnostic methods, and treatment options.