bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kia Tīmata Pai (Best Start): a study protocol for a cluster randomised trial with early childhood teachers to support children’s oral language and self-regulation development
Authors: Reese Elaine , Kokaua Jesse , Guiney Hayley , Bakir-Demir Tugce , McLauchlan Jimmy , Edgeler Clair , Schaughency Elizabeth , Taumoepeau Mele , Salmon Karen , Clifford Amanda , Maruariki Natasha , McNaughton Stuart , Gluckman Peter , Nelson Charles , O'Sullivan Justin , Wei Ran , Pergher Valentina , Amjad Sophia , Trudgen Anita , Poulton Richie 
Published: September 2023

IntroductionOral language skills are associated with children’s later self-regulation and academic skills; in turn, self-regulation in early childhood predicts successful functioning later in life. The primary objective of this study is to evaluate the separate and combined effectiveness of an oral language intervention (Enhancing Rich Conversations, ENRICH) and a self-regulation intervention (Enhancing Neurocognitive Growth with the Aid of Games and Exercise, ENGAGE) with early childhood teachers and parents for children’s oral language, self-regulation and academic functioning.Methods and analysisThe Kia Tīmata Pai (Best Start) study is a cluster randomised controlled trial with teachers and children in approximately 140 early childhood centres in New Zealand. Centres are randomly assigned to receive either oral language intervention only (ENRICH), self-regulation intervention only (ENGAGE), both interventions (ENRICH+ENGAGE) or an active control condition. Teachers’ and parents’ practices and children’s oral language and self-regulation development are assessed at baseline at age 1.5 years and approximately every 9 months to age 5, and academic performance at age 6. Teacher–child interactions will also be videotaped each year in a subset of the centres. Children’s brain and behaviour development and parent–child interactions will be assessed every 6 months to age 6 years in a subgroup of volunteers.Ethics and disseminationThe Kia Tīmata Pai trial and the two substudies (Video Project; Brain and Behaviour Development) have been approved by the University of Otago Human Ethics Committee (Health; H20/116), and reviewed for cultural responsiveness by: the Ngāi Tahu Research Committee (University of Otago), the Māori Advisory Group (University of Auckland, Liggins Institute) and an internal cultural advisory group. Results will be disseminated in international and national peer-reviewed academic journals and communicated to local, national and international organisations serving early childhood teachers, parents and young children. Data will be available via communication with the corresponding author.Trial registration numberACTRN12621000845831.
Robotic and laparoscopic gynaecological surgery: a prospective multicentre observational cohort study and economic evaluation in England
Authors: McCarthy Andrew , Samarakoon Dilupa , Gray Joanne , Mcmeekin Peter , McCarthy Stephen , Newton Claire , Nobbenhuis Marielle , Lippiatt Jonathan , Twigg Jeremy 
Published: September 2023

ObjectiveTo compare the health-related quality of life and cost-effectiveness of robot-assisted laparoscopic surgery (RALS) versus conventional ‘straight stick’ laparoscopic surgery (CLS) in women undergoing hysterectomy as part of their treatment for either suspected or proven gynaecological malignancy.DesignMulticentre prospective observational cohort study.SettingPatients aged 16+ undergoing hysterectomy as part of their treatment for gynaecological malignancy at 12 National Health Service (NHS) cancer units and centres in England between August 2017 and February 2020.Participants275 patients recruited with 159 RALS, 73 CLS eligible for analysis.Outcome measuresPrimary outcome was the European Organisation for Research and Treatment of Cancer Quality of Life measure (EORTC). Secondary outcomes included EuroQol-5 Dimension (EQ-5D-5L) utility, 6-minute walk test (6MWT), NHS costs using pounds sterling (£) 2018–2019 prices and cost-effectiveness. The cost-effectiveness evaluation compared EQ-5D-5L quality adjusted life years and costs between RALS and CLS.ResultsNo difference identified between RALS and CLS for EORTC, EQ-5D-5L utility and 6MWT. RALS had unadjusted mean cost difference of £556 (95% CI −£314 to £1315) versus CLS and mean quality adjusted life year (QALY) difference of 0.0024 (95% CI −0.00051 to 0.0057), non-parametric incremental cost-effectiveness ratio of £231 667per QALY. For the adjusted cost-effectiveness analysis, RALS dominated CLS with a mean cost difference of −£188 (95% CI −£1321 to £827) and QALY difference of 0.0024 (95% CI −0.0008 to 0.0057).ConclusionsFindings suggest that RALS versus CLS in women undergoing hysterectomy (after adjusting for differences in morbidity) is cost-effective with lower costs and QALYs. Results are highly sensitive to the usage of robotic hardware with higher usage increasing the probability of cost-effectiveness. Non-inferiority randomised controlled trial would be of benefit to decision-makers to provide further evidence on the cost-effectiveness of RALS versus CLS but may not be practical due to surgical preferences of surgeons and the extensive roll out of RALS.
Assessing treatment response to oral drugs for multiple sclerosis in real-world setting: a MAGNIMS Study
Authors: Ruggieri Serena , Prosperini Luca , Al-Araji Sarmad , Annovazzi Pietro Osvaldo , Bisecco Alvino , Ciccarelli Olga , De Stefano Nicola , Filippi Massimo , Fleischer Vinzenz , Evangelou Nikos , Enzinger Christian , Gallo Antonio , Garjani Afagh , Groppa Sergiu , Haggiag Shalom , Khalil Michael , Lucchini Matteo , Mirabella Massimiliano , Montalban Xavier , Pozzilli Carlo , Preziosa Paolo , Río Jordi , Rocca Maria A , Rovira Alex , Stromillo Maria L , Zaffaroni Mauro , Tortorella Carla , Gasperini Claudio 
Published: September 2023

BackgroundThe assessment of treatment response is a crucial step for patients with relapsing-remitting multiple sclerosis on disease-modifying therapies (DMTs). We explored whether a scoring system developed within the MAGNIMS (MRI in Multiple Sclerosis) network to evaluate treatment response to injectable drugs can be adopted also to oral DMTs.MethodsA multicentre dataset of 1200 patients who started three oral DMTs (fingolimod, teriflunomide and dimethyl fumarate) was collected within the MAGNIMS network. Disease activity after the first year was classified by the ‘MAGNIMS’ score based on the combination of relapses (0–≥2) and/or new T2 lesions (<3 or ≥3) on brain MRI. We explored the association of this score with the following 3-year outcomes: (1) confirmed disability worsening (CDW); (2) treatment failure (TFL); (3) relapse count between years 1 and 3. The additional value of contrast-enhancing lesions (CELs) and lesion location was explored.ResultsAt 3 years, 160 patients experienced CDW: 12% of them scored ‘0’ (reference), 18% scored ‘1’ (HR=1.82, 95% CI 1.20 to 2.76, p=0.005) and 37% scored ‘2’ (HR=2.74, 95% CI 1.41 to 5.36, p=0.003) at 1 year. The analysis of other outcomes provided similar findings. Considering the location of new T2 lesions (supratentorial vs infratentorial/spinal cord) and the presence of CELs improved the prediction of CDW and TFL, respectively, in patients with minimal MRI activity alone (one or two new T2 lesions).ConclusionsEarly relapses and substantial MRI activity in the first year of treatment are associated with worse short-term outcomes in patients treated with some of the oral DMTs.
Effect of Endovascular Treatment in HERMES Patients With Isolated Occlusion of the Intracranial Internal Carotid Artery
Authors: Kaiser Daniel P.O. , Nguyen Thanh N. , Campbell Bruce C.V. , Saver Jeffrey L. , Dippel Diederik W.J. , Demchuk Andrew M. , Majoie Charles B.L.M. , Brown Scott B. , Mitchell Peter J. , Gerber Johannes C. , Bracard Serge , Guillemin Francis , Jovin Tudor G. , Muir Keith W. , White Philip , Schoene Daniela , Hill Michael D. , Goyal Mayank , Puetz Volker ,   the HERMES Collaborators
Published: September 2023

Background
The optimal management of patients with symptomatic isolated internal carotid artery (ICA) occlusion is unknown. We aimed to assess whether endovascular treatment (EVT) compared with standard medical care was associated with improved functional outcomes in patients with acute symptomatic isolated intracranial ICA occlusion without involvement of the middle or anterior cerebral artery, that is, ICA‐I occlusion. Additionally, we aimed to compare ICA‐I with ICA‐L/T occlusion, which involves themiddle and anterior cerebral artery, respectively.

Methods
We analyzed data from the highly effective reperfusion evaluated in multiple endovascular stroke trials (HERMES) collaboration, which performed an individual patient data meta‐analysis of 7 randomized controlled trials conducted between 2010 and 2017 assessing the benefit of EVT compared to medical management in patients with anterior circulation large vessel occlusion. We assessed the association between EVT and 90‐day good functional outcome (modified Rankin scale scores 0–2), National Institutes of Health Stroke Scale scores at 24 hours, symptomatic intracranial hemorrhage rates and mortality in patients with ICA‐I and ICA‐L/T occlusion.

Results

We included 442 patients with intracranial ICA occlusion, of whom 38 (8.6%) had ICA‐I occlusion. In the ICA‐I group, the median age [interquartile range] was 69.5 [61.7–79.5] years, 42.1% were male, and median baseline National Institutes of Health Stroke Scale was 17 [15–20]. Compared with standard medical care alone, EVT resulted in higher good outcome rates in patients with ICA‐I (42.9% versus 25%;
P
=0.296) and ICA‐L/T occlusion (32.5% versus 14.4%;
P
<0.001), and significant improvement in National Institutes of Health Stroke Scale scores at 24 hours. Mortality and symptomatic intracranial hemorrhage rates were similar between the treatment groups for both occlusion types.

Conclusions
A minority of patients with intracranial carotid occlusion presented with ICA‐I occlusion in the HERMES population. EVT in patients with ICA‐I occlusion and moderate‐to‐severe deficit was safe and tended to be similarly effective as compared to patients with ICA‐L/T occlusion.
Transdisciplinarity, Composition, Expression: Reflections on a Spherical Way of Thinking
Authors: Sá Adriana 
Published: September 2023

Abstract
Bridging art, music, philosophy, and perception science, this article proposes a spherical way of thinking. The term evokes an inclination to sense connections between all things, implying a transdisciplinary approach to the world. The tensions between differing viewpoints can drive us to think beyond any dichotomy, and uncertainty can inspire creativity. By showing how this possibility is reflected in her work, the author hopes to activate new questions and new ways of addressing those questions.
The Text of Aristotle’s Poetics and its Arabic Translation
Authors: Torres Guerra José B. 
Published: September 2023

Abstract
This contribution highlights the importance of the Arabic version of the Poetics in establishing the text of this work. This is a well-known fact, expressly considered in the most recent editio maior of the Poetics. Nonetheless, the latter edition does not discuss all the evidence relating to the Arabic translation. This article examines two much-discussed passages of the Poetics (1454b30-32, 1448a25-28). In the first case, the Arabic testimony, despite not transmitting the text that should be edited, helps to elucidate which variant is preferred. In the second case, the text of the Arabic translation raises the question of whether its variant reading should replace the text accepted in all the editions published over the last two centuries.
Healing Nature
Authors: Lou Loretta I.T. 
Published: September 2023

Abstract
This paper provides the first ethnographic study of spiritual ecology in contemporary Hong Kong. In exploring the life stories of people who wanted to “heal” nature as well as those who were being “healed” by nature through the practice of green living, this paper illuminates the interconnection between self-transformation and social transformation within the green living circle. While the first form of self-transformation occurs when individuals consciously responded to green groups’ appeals to cultivating themselves for the environment, the second mode of self-transformation happens unintendedly as people developed an interest in green living. In conclusion, I argue that the spiritual-ecological practices under the umbrella of green living offered people in Hong Kong a means to introspect, re-organize, and even transform their lives during difficult life events and challenging life transition. In turn, the emotional and spiritual experience of self-transformation not only reinforced people’s faith in the power of nature, such positive experience was also key to perpetuating their interest and efforts in greening Hong Kong and the world beyond.
When words coalesce II
Authors: Hackstein Olav 
Published: September 2023

Abstract
This article is a sequel to my contribution entitled “When words coalesce: chunking and morphophonemic extension” in the volume The Indo-European verb (ed. H. Craig Melchert, 2012: 87–104), and intends to document cases of preverb incorporation for Proto-Indo-European (PIE). Although preverbs occurred as free morphemes with finite verbs in PIE, they could also, under conditions to be specified, undergo a change of their morphemic status from free to bound. I discuss a number of such cases and the conditions under which preverbs could undergo destressing, phonologically regular or irregular reduction, and ultimately fuse with following verbal root morphemes.
Improved Extratropical North Atlantic Atmosphere–Ocean Variability with Increasing Ocean Model Resolution
Authors: Patrizio Casey R. , Athanasiadis Panos J. , Frankignoul Claude , Iovino Doroteaciro , Masina Simona , Famooss Paolini Luca , Gualdi Silvio 
Published: September 2023

Abstract
North Atlantic atmosphere–ocean variability is assessed in climate model simulations from HighResMIP that have low resolution (LR) or high resolution (HR) in their atmosphere and ocean model components. It is found that some of the LR simulations overestimate the low-frequency variability of subpolar sea surface temperature (SST) anomalies and underestimate its correlation with the NAO compared to ERA5. These deficiencies are significantly reduced in the HR simulations, and it is shown that the improvements are related to a reduction of intrinsic (non-NAO-driven) variability of the subpolar ocean circulation. To understand the cause of the overestimated intrinsic subpolar ocean variability in the LR simulations, a link is demonstrated between the amplitude of the subpolar ocean variability and the mean state of the Labrador–Irminger Seas. Supporting previous studies, the Labrador–Irminger Seas tend to be colder and fresher in the LR simulations compared to the HR simulations and oceanic observations from EN4. This promotes upper-ocean density anomalies in this region to be more salinity-controlled in the LR simulations versus more temperature-controlled in the HR simulations and EN4 observations. It is argued that this causes the excessive subpolar ocean variability in the LR simulations by favoring a positive feedback between subpolar upper-ocean salinity and Atlantic meridional overturning circulation (AMOC) anomalies, rather than a negative feedback between subpolar SST and AMOC anomalies as in the HR simulations. The findings overall suggest that the subpolar ocean mean state impacts the variability of the ocean circulation and SSTs, including their relationship with the atmospheric circulation, in the extratropical North Atlantic.
On the Distribution of Convective and Stratiform Precipitation in Tropical Cyclones from Airborne Doppler Radar and Its Relationship to Intensity Change and Environmental Wind Shear Direction
Authors: Wadler Joshua B. , Cione Joseph J. , Rogers Robert F. , Fischer Michael S. 
Published: September 2023

Abstract
Airborne Doppler radar reflectivity data collected in hurricanes on the NOAA P-3 aircraft between 1997 and 2021 were parsed into different modes of precipitation: stratiform precipitation, shallow convection, moderate convection, and deep convection. Stratiform precipitation was the most frequent precipitation mode with 82.6% of all observed precipitation while deep convection was the most infrequent at 1.3%. When stratified by 12-h intensity change, intensifying TCs had a greater areal coverage of total convection in the eyewall compared to weakening and steady-state TCs. The largest difference in the azimuthal distributions in the precipitation modes was in deep convection, which was mostly confined to the downshear-left quadrant in weakening and steady-state hurricanes and more symmetrically distributed in intensifying hurricanes. For all intensity change categories, the most symmetrically distributed precipitation mode was stratiform rain. To build upon the results of a recent thermodynamic study, the precipitation data were recategorized for hurricanes experiencing deep-layer wind shear with either a northerly component or southerly component. Like intensifying storms, hurricanes that experienced northerly component shear had a more symmetric distribution of deep convection than southerly component shear storms, which had a distribution of deep convection that resembled weakening storms. The greatest difference in the precipitation distributions between the shear direction groups were in major hurricanes experiencing moderate (4.5–11 m s−1) wind shear values. Consistent with previous airborne radar studies, the results suggest that considering the distribution of deep convection and the thermodynamic distributions associated with differing environmental wind shear direction could aid TC intensity forecasts.

Significance Statement
This research investigates how the distribution of different types of precipitation are related to tropical cyclone (TC) intensity change. Even though deep convection—the tallest clouds—is the least frequent type of precipitation, it has the strongest relationship to intensity change with uniform distributions around the eyewall associated with intensification. Less significant relationships were noticed for shallower clouds and stratiform (lighter) rain. The study also analyzed how change in direction of the large-scale winds with height (wind shear) influences intensity change. When wind shear is northerly, there is a more symmetric distribution of deep convection compared to when wind shear is southerly. These relationships illustrate how wind shear direction influences TC convective structure and, in turn, TC intensity change.
Inferior vena cava tumor thrombus: clinical outcomes at a canadian tertiary center
Authors: Fatehi Hassanabad Ali , Ball Chad G , Kidd William T 
Published: September 2023

Objective This study reports the surgical management and outcomes of patients with malignancies affecting the IVC. Methods This was a retrospective study that considered patients undergoing surgery for IVC thrombectomy in Calgary, Canada, from 1 January 2010 to 31 December 2021. Parameters of interest included primary malignancy, the extent of IVC involvement, surgical strategy, and medium-term outcomes. Results Six patients underwent surgical intervention for malignancies that affected the IVC. One patient had a retroperitoneal leiomyosarcoma, 1 had hepatocellular carcinoma with thrombus extending into the IVC and right atrium, 1 had adrenocortical carcinoma with IVC thrombus extending into the right atrium, and 3 had clear cell renal cell carcinoma with thrombus extending into the IVC. Surgical strategy for the IVC thrombectomy varied where 5 patients required the institution of cardiopulmonary bypass and underwent deep hypothermic circulatory arrest. No patient died perioperatively. One patient died 15-months post-operatively from aggressive malignancy. Conclusion Different types of malignancy can affect the IVC and surgical intervention is usually indicated for these patients. Herein, we have reported the outcomes of IVC thrombectomy at our center.
Hypoxia-inducible factor-1α is a biomarker for predicting patients with sepsis
Authors: Tong Zewen , Wang Guangjian , Huang Wei , Zhang Hongmin , Xie Fang , Wang Xiaoting 
Published: September 2023

Objective This study aimed to investigate the potential value of serum hypoxia-inducible factor-1α (HIF-1α) concentrations as a biomarker in patients with sepsis. Methods The enrolled patients were divided into the following four groups: the intensive care unit (ICU) control group (n = 33), infection group (n = 29), septic nonshock group (n = 40), and septic shock group (n = 94). An enzyme-linked immunosorbent assay was used to measure serum HIF-1α concentrations on ICU admission. Clinical parameters and laboratory test results were also collected. Results Serum HIF-1α concentrations were significantly higher in the infection group, septic nonshock group, and septic shock group than in the ICU control group. Moreover, HIF-1α concentrations were associated with a better predictive ability for diagnosing sepsis than the Acute Physiology and Chronic Health Evaluation II score, procalcitonin concentrations, and lactate concentrations. Patients with sepsis and HIF-1α concentrations >161.14 pg/mL had a poor prognosis. Conclusions Serum HIF-1α concentrations are a useful biomarker for the diagnosis of sepsis and predicting the prognosis of patients.
Economic Report of General Inpatient Hospice in an Academic Medical Center
Authors: Rezaeiahari Mandana , Brown Clare C. , Schmit Troy , Tilford J. Mick 
Published: September 2023

This study examined if there was difference in cost of care after implementation of scattered bed inpatient hospice, first implemented in October 2021 in an Academic Medical Center in Arkansas. This retrospective, cross-sectional study compared the cost of care during the pre-implementation phase (n = 121, July 2020-March 2021) to patients admitted to hospice care (n = 84, October 2021-June 2022). Hospice length of stay (LOS) was 4 times longer than the LOS after a Do Not Resuscitate order (DNR) was placed for patients in the pre-implementation period. The end of life costs after the implementation of inpatient hospice was 69% less than the end of life costs in the pre-implementation period.
Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell
Authors: Ogata Hiroshi , Kitamura Shigeki , Fujiwara Makoto , Shimizu Masaru , Tan Chengbo , Zhao Songji , Maejima Yuko , Shimomura Kenju 
Published: September 2023

Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (KATP) channels and induces insulin secretion. However, there are no detail reports that measure the effective dose that can close KATP channels and induce insulin secretion. In this study, whole-cell patch clamp recording was utilized to measure the effect of SMX on KATP channel activity on pancreatic β cells. Also, the static incubation assay with mice islets was assessed to measure the insulin secretion capacity of SMX. SMX was shown to inhibit the KATP channel in pancreatic β cell membrane and induce insulin secretion in relatively high concentration. The half maximal inhibitory concentration (IC50) for KATP channel activity of SMX was .46 ± .08 mM. It was also shown that a near IC50 concentration of SMX (.5 mM) was able to nearly fully block the KATP channel when simultaneously applied with low concentration sulfonylurea, tolbutamide (.01 mM). Our present data provide important information for the clinical use of SMX to treat infection in diabetic patients using sulfonylureas.