bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of grafting silane coupling agents on superhydrophobicity of carbonyl iron/SiO2 particles for efficient oil/water mixture and emulsion separation
Authors: Rabbani Yahya , Shayesteh Hadi , Haghshenas Nima , Safarzadeh Khosrowshahi Mobin 
Published: January 2023

AbstractThe present study demonstrated the wettability properties of grafting silane coupling agents on carbonyl iron (CI)/SiO2 particles for efficient oil/water mixture and emulsion separation. CI particles were first reacted with Tetraethoxysilane (TEOS) to create a magnetic component. Then, CI/SiO2 particles were altered by 1H,1H,2H,2H-perfluorodecyltriethoxysilane (FAS) and Hexamethyldisilazane (HDMS) to create magnetic superhydrophobic/superoleophilic, recyclable, and reusable sorbent powders. The water contact angle (WCA) values of the as-prepared particles, CI, CI/SiO2, CI/SiO2@FAS, and CI/SiO2@HMDS, were 5.4° ± 1.3°, 6.4° ± 1.4°, 151.9° ± 2.1°, and 170.1° ± 1.1°, respectively. In addition, the oil contact angles (OCAs) of a variety of oils were found to be equivalent to 0°. Hence, superhydrophobic/superoleophilic particles for kind of different oils were shown sorption capacities of 1.7–3.1 g/g and 2.5–4.3 g/g for CI/SiO2@FAS, and CI/SiO2@HMDS, respectively. Besides, for 1%w/w hexane/water emulsion separation efficiency higher than 99%, the lowest mass was obtained at 50 and 200 mg for CI/SiO2@HDMS and CI/SiO2@HDMS, respectively, suggesting a new effective material for separating tiny oil droplets. Also, the reusability and chemical durability of the superhydrophobic samples made them a prime candidate for use in different harsh conditions.
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis
Authors: Fujimori Takeshi , Shibayama Yuki , Kanda Takahiro , Suzuki Kenta , Ogawa Daisuke , Ishikawa Ryou , Kadota Kyuichi , Matsunaga Toru , Tamiya Takashi , Nishiyama Akira , Miyake Keisuke 
Published: January 2023

AbstractGlioblastoma is characterized by a strong self-renewal potential and poor differentiated state. We have reported previously that the (pro)renin receptor [(P)RR] is a potential target for glioma therapy by silencing the (P)RR gene. Here, we have examined the effects of a monoclonal antibody against (P)RR on gliomagenesis. Human glioma cell lines (U251MG and U87MG) and a glioma stem cell line (MGG23) were used for the in vitro study. The expressions of the Wnt/β-catenin signaling pathway (Wnt signaling pathway) components and stemness markers were measured by Western blotting. The effects of the (P)RR antibody on cell proliferation, sphere formation, apoptosis and migration were also examined. Subcutaneous xenografts were also examined in nude mice. Treatment with the (P)RR antibody reduced expression of Wnt signaling pathway components and stemness markers. Furthermore, the (P)RR antibody reduced cell proliferation and decreased sphere formation significantly. The treatment also suppressed migration and induced apoptosis. In a subcutaneous xenograft model, systemic administration of the (P)RR antibody reduced tumor volume significantly. These data show that treatment with the (P)RR antibody is a potential therapeutic strategy for treating glioblastoma.
The effects of torsion on horizontal motor fusion and stereopsis
Authors: Feng Tongzhu , Li Yueping , Zhang Wei 
Published: January 2023

AbstractTo investigate the effects of ocular torsion on horizontal motor fusion and stereopsis in normal adults and to probe the effects of torsion on peripheral fusion, macular fusion and foveal fusion. Twenty-five normal adults aged 30–38 were enrolled in this study. During the synoptophore assessment, the break points (BP) and recovery points (RP) of convergent fusion (CF) and divergent fusion (DF) and random-dots stereopsis were measured and analyzed at intorsion and extorsion of 3°, 5°, 7°, and 9°. According to the different sizes of the retinal areas stimulated by the synoptophore slides, fusion was classified into three categories: peripheral fusion (p-F), macular fusion (m-F) and foveal fusion (f-F). The p-F, m-F and f-F were analyzed and compared at the same torsional angle. There were significant differences in BPCF, RPCF, BPDF and RPDF among different torsion angles (ANOVA, P < 0.05). The Tukey's multiple comparison test showed that BPCF and RPCF of p-F, m-F and f-F decreased significantly at extorsion and intorsion ≥ 5°, compared with baseline (0° torsion) (P < 0.05). Compared with the baseline, BP of DF decreased significantly at torsion angles ≥ 3°, ≥ 5° and ≥ 7° for p-F, m-F, and f-F, respectively (P < 0.05), and RP of DF decreased significantly at torsion angles ≥ 5°, ≥ 9° and ≥ 7° for p-F, m-F, and f-F, respectively (P < 0.05). Comparison among p-F, m-F and f-F revealed significant differences only in BPCF at an intorsion of 3°, extorsion of 3° and the baseline (ANOVA, P < 0.05). There was a significant difference in the proportion of subjects with different sizes of RDS at different torsional angles (Fisher's exact test, P = 0.000). Fine stereopsis was damaged with increasing torsion. Torsion within the normal range of cyclofusion affects the horizontal motor fusion of convergent and divergent fusion and stereopsis. Torsion ≥ 5° should be considered during strabismus surgery for regaining fine binocular vision.
Non-reciprocal acoustoelectric microwave amplifiers with net gain and low noise in continuous operation
Authors: Hackett Lisa , Miller Michael , Weatherred Scott , Arterburn Shawn , Storey Matthew J. , Peake Greg , Dominguez Daniel , Finnegan Patrick S. , Friedmann Thomas A. , Eichenfield Matt 
Published: January 2023

AbstractPiezoelectric acoustic devices that are integrated with semiconductors can leverage the acoustoelectric effect, allowing functionalities such as gain and isolation to be achieved in the acoustic domain. This could lead to performance improvements and miniaturization of radio-frequency electronic systems. However, acoustoelectric amplifiers that offer a large acoustic gain with low power consumption and noise figure at microwave frequencies in continuous operation have not yet been developed. Here we report non-reciprocal acoustoelectric amplifiers that are based on a three-layer heterostructure consisting of an indium gallium arsenide (In0.53Ga0.47As) semiconducting film, a lithium niobate (LiNbO3) piezoelectric film, and a silicon substrate. The heterostructure can continuously generate 28.0 dB of acoustic gain (4.0 dB net radio-frequency gain) for 1 GHz phonons with an acoustic noise figure of 2.8 dB, while dissipating 40.5 mW of d.c. power. We also create a device with an acoustic gain of 37.0 dB (11.3 dB net gain) at 1 GHz with 19.6 mW of d.c. power dissipation and a non-reciprocal transmission of over 55 dB.
Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model
Authors: Custodio Raly James Perez , Kim Hee Jin , Kim Jiyeon , Ortiz Darlene Mae , Kim Mikyung , Buctot Danilo , Sayson Leandro Val , Lee Hyun Jun , Kim Bung-Nyun , Yi Eugene C. , Cheong Jae Hoon 
Published: January 2023

AbstractChildren with attention-deficit/hyperactivity disorder (ADHD) often struggle with impaired executive function, temporal processing, and visuospatial memory, hallmarks of the predominantly inattentive presentation (ADHD-PI), subserved by the hippocampus. However, the specific genes/proteins involved and how they shape hippocampal structures to influence ADHD behavior remain poorly understood. As an exploratory tool, hippocampal dentate gyri tissues from thyroid hormone-responsive protein overexpressing (THRSP OE) mice with defining characteristics of ADHD-PI were utilized in proteomics. Integrated proteomics and network analysis revealed an altered protein network involved in Wnt signaling. Compared with THRSP knockout (KO) mice, THRSP OE mice showed impaired attention and memory, accompanied by dysregulated Wnt signaling affecting hippocampal dentate gyrus cell proliferation and expression of markers for neural stem cell (NSC) activity. Also, combined exposure to an enriched environment and treadmill exercise could improve behavioral deficits in THRSP OE mice and Wnt signaling and NSC activity. These findings show new markers specific to the ADHD-PI presentation, converging with the ancient and evolutionary Wnt signaling pathways crucial for cell fate determination, migration, polarity, and neural patterning during neurodevelopment. These findings from THRSP OE mice support the role of Wnt signaling in neurological disorders, particularly ADHD-PI presentation.
Insights into pyrrolysine function from structures of a trimethylamine methyltransferase and its corrinoid protein complex
Authors: Li Jiaxin , Kang Patrick T. , Jiang Ruisheng , Lee Jodie Y. , Soares Jitesh A. , Krzycki Joseph A. , Chan Michael K. 
Published: January 2023

AbstractThe 22nd genetically encoded amino acid, pyrrolysine, plays a unique role in the key step in the growth of methanogens on mono-, di-, and tri-methylamines by activating the methyl group of these substrates for transfer to a corrinoid cofactor. Previous crystal structures of the Methanosarcina barkeri monomethylamine methyltransferase elucidated the structure of pyrrolysine and provide insight into its role in monomethylamine activation. Herein, we report the second structure of a pyrrolysine-containing protein, the M. barkeri trimethylamine methyltransferase MttB, and its structure bound to sulfite, a substrate analog of trimethylamine. We also report the structure of MttB in complex with its cognate corrinoid protein MttC, which specifically receives the methyl group from the pyrrolysine-activated trimethylamine substrate during methanogenesis. Together these structures provide key insights into the role of pyrrolysine in methyl group transfer from trimethylamine to the corrinoid cofactor in MttC.
Satellite-based quantum information networks: use cases, architecture, and roadmap
Authors: de Forges de Parny Laurent , Alibart Olivier , Debaud Julien , Gressani Sacha , Lagarrigue Alek , Martin Anthony , Metrat Alexandre , Schiavon Matteo , Troisi Tess , Diamanti Eleni , Gélard Patrick , Kerstel Erik , Tanzilli Sébastien , Van Den Bossche Mathias 
Published: January 2023

AbstractQuantum Information Networks (QINs) attract increasing interest, as they enable connecting quantum devices over long distances, thus greatly enhancing their intrinsic computing, sensing, and security capabilities. The core mechanism of a QIN is quantum state teleportation, consuming quantum entanglement, which can be seen in this context as a new kind of network resource. Here we identify use cases per activity sector, including key performance targets, as a reference for the network requirements. We then define a high-level architecture of a generic QIN, before focusing on the architecture of the Space segment, with the aim of identifying the main design drivers and critical elements. A survey of the state-of-the-art of these critical elements is presented, as are issues related to standardisation. Finally, we explain our roadmap to developing the first QINs and detail the already concluded first step, the design and numerical simulation of a Space-to-ground entanglement distribution demonstrator.
On hardware aging for practical RIS‐assisted communication systems
Authors: Wang Ke , Lam Chan‐Tong , Ng Benjamin K. 
Published: January 2023

AbstractIn this letter, reconfigurable intelligent surface (RIS) is studied from an electronic device reliability perspective. Runtimes and lifetimes of the RIS are introduced for the first time as impairment factors that degrade the system performance. In particular, Weibull distributions are used to model the runtime‐related hardware aging (HA) effect on the RIS at first. Then, a practical RIS‐assisted system model with phase‐dependent amplitude variations, residual hardware impairments, and HA effects, is obtained. Besides, closed‐form expressions of the received signal power and spectral efficiency for the proposed system are also derived. Analytical and numerical evaluations reveal that the HA effect on the RIS is the major impairment factor when the runtime is beyond the lifetime of the RIS.
Port‐assignment modelling of anti‐parallel Schottky barrier diode and 0.3‐THz sub‐harmonic mixer design
Authors: Kim Young‐Ho , Shin Jun‐Hwan , Park Dong Woo , Lee Il‐Min , Park Kyung Hyun 
Published: January 2023

AbstractThis letter presents a new port‐assignment model of an anti‐parallel Schottky barrier diode (AP‐SBD) and a 0.3‐THz sub‐harmonic mixer (SHM) as the application design. Using the proposed method, the AP‐SBD is accurately modelled compared to conventional modelling methods. Because the characteristics of an AP‐SBD have the greatest impact on mixer performance, an accurate modelling method for AP‐SBD helps design SHMs with good performance. To verify the proposed modelling in the terahertz region, a 0.3‐THz SHM based on the modelled AP‐SBD is designed and assembled. The measurement result reveals that the optimal double‐sideband (DSB) conversion loss of the mixer is 6.7 to 10.1 dB within 279 to 318 GHz when the fixed local oscillator (LO) signal is 6.4 dBm at 152 GHz. All measurement results confirm that the proposed methodology is concise and feasible for the design of terahertz SHMs.
Pediatric Multiple Sclerosis—Experience of a Tertiary Care Center
Authors: Martins Cecília , Samões Raquel , Silva Ana Martins , Santos Ernestina , Figueiroa Sónia 
Published: January 2023

Abstract
Background Pediatric-onset multiple sclerosis (POMS) accounts for 3 to 10% of all MS diagnoses. POMS is usually characterized by prominent disease activity, and patients are at higher risk of developing physical disability and cognitive impairment.
Objective This article characterizes a cohort of POMS patients followed at the pediatric neurology unit of a Portuguese tertiary hospital.
Methods Retrospective observational study. Clinical records of all patients with POMS between 2011 and 2020 were revised.
Results A total of 21 patients, with a female:male ratio of 11:10 and a mean age of onset of 14.8 years were included. Clinical manifestations at presentation included myelitis in eight patients (two with associated brainstem syndrome), optic neuritis in six (one with associated cerebellar syndrome), supratentorial symptoms in four, and isolated brainstem syndrome in two. Twenty patients had oligoclonal immunoglobulin G bands in cerebrospinal fluid. Supra- and infratentorial involvement was identified in the first brain magnetic resonance imaging of nine patients. Initial relapses were treated with intravenous steroids in 19 patients. The mean time for diagnosis was 2.8 months. Eleven patients were on first-line treatment (nine on β-interferon, two on teriflunomide) and 10 on second-line treatment (six on natalizumab, three on fingolimod, one on ocrelizumab). The mean annual relapse rate was 0.29 (range, 0.01–3), and the median Expanded Disability Status Scale was 1. Four patients reported learning disabilities and/or cognitive deficits.
Conclusion About half of patients in this cohort were on second-line disease-modifying treatment, with 19% showing cognitive impairment. Efforts to establish an early diagnosis are crucial to improving these patients' outcomes.
Clinical Features of COVID-19 and Differentiation from Other Causes of CAP
Authors: Gao Catherine A. , Pickens Chiagozie I. , Morales-Nebreda Luisa , Wunderink Richard G. 
Published: January 2023

AbstractCommunity-acquired pneumonia (CAP) is a significant cause of morbidity and mortality, one of the most common reasons for infection-related death worldwide. Causes of CAP include numerous viral, bacterial, and fungal pathogens, though frequently no specific organism is found. Beginning in 2019, the COVID-19 pandemic has caused incredible morbidity and mortality. COVID-19 has many features typical of CAP such as fever, respiratory distress, and cough, and can be difficult to distinguish from other types of CAP. Here, we highlight unique clinical features of COVID-19 pneumonia such as olfactory and gustatory dysfunction, lymphopenia, and distinct imaging appearance.
Risk Factors Associated with Postoperative CSF Leak in Extrasellar Tumors
Authors: Zhang Huan , Peeters Sophie , Vengorivich Gennadiy , Antoury Layal , Park Ki Wan , Wells Christine , Suh Jeffrey D. , Lee Jivianne T. , Heaney Anthony , Bergsneider Marvin , Kim Won , Wang Marilene B. 
Published: January 2023

Abstract
Objective While postoperative cerebrospinal fluid (CSF) leak rates of pituitary tumors have been frequently studied, there are fewer studies examining postoperative CSF leak rates for extrasellar tumors. The purpose of this study was to identify risk factors for the development of postoperative CSF leak in patients undergoing endoscopic surgery for extrasellar tumors.
Methods A retrospective chart review was done for patients who underwent endoscopic resection for extrasellar tumors between 2008 and 2020. Age, gender, tumor type, tumor location, tumor size, reconstruction technique, medical comorbidities, and other potential risk factors were identified. Data was analyzed to identify significant risk factors for development of postoperative CSF leak.
Results There were 100 patients with extrasellar tumors who developed intraoperative CSF leaks. Seventeen patients (17%) developed postoperative CSF leaks. Leaks occurred at a median of 2 days following surgery (range 0–34 days). Clival tumors had a significantly higher incidence of postoperative leak than those in other sites (p < 0.05). There were no significant differences in other locations, body mass index, tumor size, reconstruction technique, medical comorbidities, or other factors. There were nearly twice as many intraoperative grade III leaks in those who developed postoperative CSF leak, but this was not statistically significant (p = 0.12).
Conclusion Extrasellar tumors, particularly clival tumors, have a higher rate of postoperative CSF leak than pituitary tumors. Prophylactic lumbar drains can be considered for patients at high risk for developing postoperative CSF leak.
Prenatal Vaccination Patterns among Birthing Individuals with History of Preterm Birth in the Pre- and Post-COVID Era
Authors: Ramey-Collier Khaila L. , Okunbor Jennifer I. , Lunn Siera R. , Feng Kelvin , Truong Tracy , Weaver Kristin E. , Swamy Geeta K. , Wheeler Sarahn M. 
Published: January 2023

Objective This study aims to explore vaccination acceptance among individuals with a history of preterm birth between March and June during the pre-COVID (2019), early-COVID (2020), and late-COVID (2021) periods.
Study Design This is a cross-sectional, retrospective cohort study of pregnant individuals with a history of preterm birth (<37 weeks' gestation) who initiated care of a subsequent pregnancy during pre-COVID (March–June 2019), early-COVID (March–June 2020), or late-COVID (March–June 2021). The primary outcome of interest was vaccination status for influenza, Tdap, and COVID-19 vaccines. Fisher's exact and chi-square tests were used to investigate association between vaccination status and time periods, race/ethnicity, and insurance.
Results Among 293 pregnancies, influenza vaccination rate was highest in early-COVID (p < 0.05). There was no statistically significant difference in Tdap or COVID-19 vaccination between time periods. COVID-19 vaccination was highest in individuals with private insurance (p < 0.05). There was no statistically significant difference in vaccination status by race/ethnicity.
Conclusion In this study on high-risk pregnant individuals, the majority of our cohort remained unvaccinated against COVID-19 into the late-COVID period. Additionally, their influenza vaccination rates were greater than the national average in early-COVID and substantially lower than the national average in late-COVID. This shift in influenza vaccination acceptance may have been sparked by COVID-19 vaccine distribution beginning in January 2021 leading to overall vaccination hesitancy. Standardized guidelines and counseling concerning prenatal safety in recommended immunizations may serve as important tools of reassurance and health promotion.
Key Points
Spin-state gaps and self-interaction-corrected density functional approximations: Octahedral Fe(II) complexes as case study
Authors: Romero Selim , Baruah Tunna , Zope Rajendra R. 
Published: January 2023

Accurate prediction of a spin-state energy difference is crucial for understanding the spin crossover phenomena and is very challenging for density functional approximations, especially for local and semi-local approximations due to delocalization errors. Here, we investigate the effect of the self-interaction error removal from the local spin density approximation (LSDA) and Perdew–Burke–Ernzerhof generalized gradient approximation on the spin-state gaps of Fe(II) complexes with various ligands using recently developed locally scaled self-interaction correction (LSIC) by Zope et al. [J. Chem. Phys. 151, 214108 (2019)]. The LSIC method is exact for one-electron density, recovers the uniform electron gas limit of the underlying functional, and approaches the well-known Perdew–Zunger self-interaction correction (PZSIC) as a particular case when the scaling factor is set to unity. Our results, when compared with reference diffusion Monte Carlo results, show that the PZSIC method significantly overestimates spin-state gaps favoring low spin states for all ligands and does not improve upon density functional approximations. The perturbative LSIC-LSDA using PZSIC densities significantly improves the gaps with a mean absolute error of 0.51 eV but slightly overcorrects for the stronger CO ligands. The quasi-self-consistent LSIC-LSDA, such as coupled-cluster single double and perturbative triple [CCSD(T)], gives a correct sign of spin-state gaps for all ligands with a mean absolute error of 0.56 eV, comparable to that of CCSD(T) (0.49 eV).
Non-negligible roles of charge transfer excitons in ultrafast excitation energy transfer dynamics of a double-walled carbon nanotube
Authors: Xie Rui-Fang , Zhang Jing-Bin , Wu Yang , Li Laicai , Liu Xiang-Yang , Cui Ganglong 
Published: January 2023

Herein, we employed a developed linear response time dependent density functional theory-based nonadiabatic dynamics simulation method that explicitly takes into account the excitonic effects to investigate photoinduced excitation energy transfer dynamics of a double-walled carbon nanotube (CNT) model with different excitation energies. The E11 excitation of the outer CNT will generate a local excitation (LE) |out*〉 exciton due to its low energy, which does not induce any charge separation. In contrast, the E11 excitation of the inner CNT can generate four kinds of excitons with the LE exciton |in*〉 dominates. In the 500-fs dynamics simulation, the LE exciton |in*〉 and charge transfer (CT) excitons |out−in+〉 and |out+in−〉 are all gradually converted to the |out*〉 exciton, corresponding to a photoinduced excitation energy transfer, which is consistent with experimental studies. Finally, when the excitation energy is close to the E22 state of the outer CNT (∼1.05 eV), a mixed population of different excitons, with the |out*〉 exciton dominated, is generated. Then, photoinduced energy transfer from the outer to inner CNTs occurs in the first 50 fs, which is followed by an inner to outer excitation energy transfer that is completed in 400 fs. The present work not only sheds important light on the mechanistic details of wavelength-dependent excitation energy transfer of a double-walled CNT model but also demonstrates the roles and importance of CT excitons in photoinduced excitation energy transfer. It also emphasized that explicitly including the excitonic effects in electronic structure calculations and nonadiabatic dynamics simulations is significant for correct understanding/rational design of optoelectronic properties of periodically extended systems.