bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crystal structure of 9-chloro-2,3,4,4a,5,6-hexahydro-1H-pyrido [1′,2′:1,6]pyrazino[2,3-b]quinoxaline, C14H15ClN4
Authors: Chen Qiang , Fu Xian Wu , Yu Yu 
Published: January 2025

Abstract
C14H15ClN4, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 7.4938(4) Å, b = 9.1046(5) Å, c = 11.0448(5) Å, α = 113.516(5)°, β = 91.811(4)°, γ = 109.583(5)°, V = 638.98(6) Å3, Z = 2, Rgt
(F) = 0.0700, wRref
(F
2) = 0.1909, T = 100 K.
Synthesis and crystal structure of-(3S,10S,13S,17S)-N-(2-methoxyphenyl)-10,13-dimethyl-17-((R)-1-(p-tolylamino)ethyl)hexadecahydro-1H-cyclopenta[α]phenanthren-3-amine, C35H50N2O
Authors: Yang Mei , Wei Peng , Sun Yi-Chun , Ye Jiang-Hai , Zou Juan , He Kang 
Published: January 2025

Abstract
C35H50N2O, orthorhombic, P212121 (no. 19), a = 6.7114 Å, b = 19.6699(9) Å, c = 22.7057(10) Å, V = 2,997.4(2) Å3, Z = 4, Rgt
(F) = 0.0401, wRref
(F
2) = 0.0995, T = 297(2) K.
Crystal structure of new barium lithium manganese fluorides: Ba14Li1.87Mn14.13F68 with a Jarlite–related structure
Authors: Chang Hong Young , Kim Sun Woo 
Published: January 2025

Abstract
Ba14Li1.87Mn14.13F68, monoclinic, C2/m (no. 12), a = 16.9675(7) Å, b = 11.5326(5) Å, c = 7.5783(3) Å, β = 102.4190(10)°, V = 1448.22(10) Å3, Z = 1, R

gt
(F) = 0.0177, wR

ref
(F
2) = 0.0454, T = 296(2) K.
ALÉM DO UTILITARISMO: A RUA COMO ESPAÇO DE CONTINUIDADES E AFETIVIDADES
Authors: Claudino Livio Sergio Dias 
Published: January 2025

Resenha de: LEMÕES, Tiago. A família, a rua e os afetos: uma etnografia da construção de vínculos entre homens e mulheres em situação de rua. São Paulo: Novas Edições Acadêmicas, 2013. 257 p. Clique em PDF para acessar o arquivo.
Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry
Authors: Mathara Diddhenipothage Shani A D , Beck Katharina J , Amiyangoda Gayana , Bryce Jillian , Cima Luminita , De Groote Katya , Deyanova Yana , Globa Evgenia , Herrmann Gloria , Juul Anders , Kjaer Anna Sophie L , Pedersen Anette Tønnes , Poyrazoglu Sukran , Probst-Scheidegger Ursina , Sas Theo C J , Fica Simona , Seneviratne Sumudu Nimali , Witczak Justyna Karolina , Orchard Elizabeth , Tomlinson Jeremy W , Ahmed S Faisal , Turner Helen E 
Published: January 2025

IntroductionCardiovascular disease is the most common cause of death in Turner syndrome (TS) for which arterial hypertension has a direct influence and is a key modifiable risk factor.ObjectiveTo investigate the prevalence and patterns of hypertension diagnosis and management in adult patients with TS who are registered in a large international multicentre database (TS-HTN study).MethodsRetrospective multicentre observational study of patients aged ≥18 years included in the I-TS (International-TS) registry (2020–2022), using registry and participating centre-collected data.ResultsTwelve international centres participated, including 182 patients with a median age of 28 years (IQR 23–37.2). Arterial hypertension was recorded in 13.2% (n = 24). The median age at hypertension diagnosis was 27 years (range 10–56), with 92% aged less than 50 years at diagnosis. The majority (75%) were classified as primary hypertension (n = 18). In binomial regression analysis, higher body mass index was the only parameter significantly associated with the occurrence of hypertension (B = 1.487, P = 0.004). Among patients with aortic disease (n = 9), 50% had systolic BP ≥ 130 mmHg and 66.6% had diastolic BP ≥ 80 mmHg during the last clinic review. Angiotensin-converting enzyme inhibitors were the most common (n = 16) medication prescribed, followed by angiotensin receptor blockers (n = 6), beta-blockers (n = 6) and calcium channel blockers (n = 6).ConclusionsArterial hypertension is common in TS and occurs at a young age. Overweight/obesity was a notable risk factor for hypertension. The frequency of suboptimal BP control among high-risk patients highlights the importance of increased awareness and TS-specific consensus guidance on management.
ERα phosphorylated at Ser309 participates in regulating luminal environment of efferent ducts and epididymis in mice
Authors: Wei Jinhua , Cheng Pang , Ma Binfang , Feng Xiao , Ma Junxian , Zhao Jie , Zhao Yanqiu , Li Zhen 
Published: January 2025

In briefThe epididymis plays an important role in sperm maturation and male fertility. This study provides evidence that estrogen receptor alpha (ERα/ESR1) phosphorylated at Ser309 is essential for efferent duct fluid reabsorption and epididymal luminal acidification to create and maintain the optimal luminal milieu in mice.AbstractERα (ESR1) plays an important role in male reproduction and fertility. Its activity is modulated by phosphorylation of multiple amino acid residues. The ERα phosphorylated at serine 305 (S305) in human cells (homologous with serine 309 in mice) induces ligand-independent ERα activity. Here, we studied the effect of ERα phosphorylation at S309 on the reproductive function of male mice. ERα309 (p.S309A, ERαS309A) knock-in (KI) mice were generated by homologous recombination in mouse embryonic stem cells. The ERαS309A KI males were subfertile with decreased sperm motility, dilated lumen and thinned epithelium of efferent ducts. Ultrastructural observation showed that the area of endocytic vesicles and lysosomes in the non-ciliated cells and the number of cilia in the ciliated cells were significantly reduced in the efferent ducts of the ERαS309A KI mice. The pH value of the epididymal fluid was significantly higher in all regions of epididymis in the ERαS309A KI mice. Moreover, the expression of aquaporin 9 (AQP9) in the efferent ducts and carbonic anhydrase XII (CAR12) in the epididymis was decreased in ERαS309A KI mice. The results indicate that the ERα phosphorylated at Ser309 participates in maintaining the unique luminal milieu by regulating the expression of critical regulators of fluid/ion transport in the efferent ducts and epididymis.
ПРОТОТИПИЧЕСКИЙ НАРРАТИВ И СОДЕРЖАТЕЛЬНОЕ РАЗНОБРАЗИЕ НАРРАТИВА
Authors: БАРБАШИНА Э.В. 
Published: January 2025

«Нарративный поворот» является одним из основных, наряду с лингвистическим, онтологическим, произошедшими во второй половине ХХ века. Следствием «нарративного поворота» стало применение нарративного подхода во всех областях социальногуманитарного познания, расширительное понимание самого нарратива, невозможность категоризации нарративных исследований. Варианты различного понимания нарратива обусловлены, вопервых, областью применения: литературоведение, история, социология, психология и др. Вовторых, содержательнометодологическим подходами: конструктивистский, натуралистический, структуралистский, постструктуралистский, герменевтический и др. Втретьих, применением его как одного из многих методов качественных исследований, основного метода, принципа исследования или же признанием нарративной парадигмы. Применение модернизированного варианта принципа «семейного сходства» (Familienähnlichkeit, Л. Витгенштейн) позволяет непротиворечивым образом объединить и структурировать многообразие нарративных исследований.
"Narrative turn" is one of the main, along with linguistic, ontological, that occurred in the second half of the twentieth century. The consequence of the "narrative turn" was the application of the narrative approach in all areas of sociohumanitarian cognition, an expanded understanding of the narrative itself, and the impossibility of categorising narrative research. The variants of different understanding of narrative are conditioned, firstly, by the field of application: literary studies, history, sociology, psychology and others. Secondly, contentmethodological approaches: constructivist, naturalist, structuralist, poststructuralist, hermeneutic, etc. Thirdly, its application as one of the many methods of qualitative research, the main method, research principle or the recognition of the narrative paradigm. The application of a modernised version of the principle of «family resemblance» (Familienähnlichkeit, L. Wittgenstein) allows us to unite and structure the diversity of narrative research in a consistent way.
СТРУКТУРА НАЦІОНАЛЬНОЇ ЕКОНОМІКИ В УМОВАХ ГЛОБАЛЬНИХ ЗМІН
Authors: ЗВЄРЯКОВ Михайло 
Published: January 2025

Проведено теоретичне дослідження структурних змін у національній економіці в умовах глобальних трансформацій. Структура економіки, успадкована Україною, була результатом форсованої індустріалізації, а не продуктом еволюційного розвитку ринкової системи, тому не могла змінюватися під впливом ринкових сил і оновлювати свій виробничий апарат на основі циклічного руху промислового капіталу. Показано, що структурні зміни в національній економіці відбуваються під впливом ринкових сигналів і охоплюють у першу чергу основу економіки – підприємство. Якщо на рівні підприємства здійснюється циклічне оновлення промислового капіталу, то таке підприємство функціонує на ринкових засадах. Проведений аналіз структурних змін під впливом ринкових сил свідчить, що траєкторії руху експортно-сировинних і внутрішньоорієнтованих галузей дедалі більше розходяться.
Дослідження динаміки структури валової доданої вартості за 2010–2022 рр. довело, що в Україні не відбулося суттєвих структурних змін за рахунок модернізації виробництв. Проведені структурні зміни призвели до скорочення переробних галузей промисловості й зростання питомої ваги у створенні доданої вартості сільського господарства, добувної промисловості, а також інформаційної і телекомунікаційної галузей. Структура національної економіки адаптувалася до вимог внутрішнього і зовнішнього попиту. За відсутності структурної політики зміни в структурі економіки відбуваються спонтанно, а не під впливом цілеспрямованих дій державних органів. Запропоновано досягнення Україною конкурентоспроможності на ринках готових товарів визнати метою модернізації, національною стратегією. Остання передбачає проведення структурної політики, яка найповніше відповідатиме особливостям національної стратегії підвищення конкурентоспроможності. Показано, що бажаний напрям структурної політики – інновації, пов’язані з пристосуванням залучених технологій до працюючих підприємств. Це вимагає суттєвих інституційних перетворень, здатних забезпечити наздоганяючий розвиток у повоєнний період.
Epidemiology of Pediatric Functional Abdominal Pain Disorders: A Meta-Analysis
Authors: Koen Vermeijden Nicolaas , de Silva Leilani , Manathunga Supun , Spoolder Daphne , Korterink Judith , Vlieger Arine , Rajindrajith Shaman , Benninga Marc 
Published: January 2025

CONTEXT
Functional abdominal pain disorders (FAPDs) are debilitating disorders with unknown current prevalence.

OBJECTIVE
To estimate global prevalence rates of FAPDs, their entities, and variations by diagnostic criteria, geography, gender, and age.

DATA SOURCES
Medline, Embase, CINAHL, PsycInfo, and Cochrane Library were searched through October 14, 2024.

STUDY SELECTION
Epidemiological studies of birth cohorts, school based, and from general population samples reporting FAPD prevalence in children (aged 4–18 years) using the Rome criteria.

DATA EXTRACTION
Two researchers independently performed screening, data extraction, and quality assessment.

RESULTS
A total of 66 studies, encompassing 201 134 participants from 29 countries, were included. The estimated global pooled prevalence of FAPDs was 11.7% (95% CI, 10.5%–13.1%). The most prevalent type was irritable bowel syndrome (5.8%; 95% CI, 4.5–7.4%), while functional abdominal pain–not otherwise specified was least prevalent (1.2%; 95% CI, 0.7%–2.1%)). Prevalence was highest using Rome III (13.2%; 95% CI, 11.3%–15.3%) and lowest under Rome IV criteria (9.0%; 95% CI, 6.7%–12.0%; P = .05). Girls had higher prevalence (14.4%; 95% CI, 12.5%–16.6%) than boys (9.4%; 95% CI, 7.8%–11.4%; P &lt; .01). FAPDs were nonsignificantly more prevalent in Asia (13.0%; 95% CI, 10.4%–16.3%) compared to Europe (8.3%; 95% CI, 6.4%–10.7%) and North America (7.7%; 95% CI, 4.3–13.6; P = .09). No differences by age (P = .14) were recorded. Contributing factors include anxiety, depression, stress, negative life events, and poor sleep.

LIMITATIONS
Language restrictions, significant interstudy heterogeneity, and underrepresentation from Africa.

CONCLUSIONS AND RELEVANCE
FAPDs affect over 1 in 9 children worldwide, with higher prevalence in girls and those with psychological stressors.
À guisa de apresentação: mulheres escritoras de ontem e de hoje
Authors: QUEIROZ Juliana Maia de , KÜTTER Cíntia Acosta , MÜLLER Andréa Correia Paraíso 
Published: January 2025

O número sessenta e seis da Revista Moara foi idealizado como um espaço de apresentação e discussão das principais pesquisas atuais acerca da literatura escrita por mulheres do século XIX àquelas da contemporaneidade. Nossa chamada recebeu inúmeros artigos, sendo a maioria deles voltados para escritoras brasileiras e alguns poucos que versam também sobre obras de autoras latino-americanas. As leitoras e os leitores de nosso número poderão, assim, realizar um passeio por obras e mulheres que se lançaram ao fazer literário no passado, tais como a oitocentista Maria Benedita Câmara Bormann (Délia), Carolina Maria de Jesus no século XX, chegando aos dias atuais com Conceição Evaristo e Márcia Kambeba, por exemplo.
PENDIDIKAN KARAKTER BERBASIS INOVASI PADA SAAT BELAJAR DARING DI SDIT BANDAR LAMPUNG SELAMA MASA PANDEMI COVID-19
Authors: Ruswanto  , Kalsum Umi , Sunarto  
Published: January 2025

Thei Covid-19 paindeimic hais haid ai significaint impaict on vairious aispeicts of lifei, including thei eiducaition seictor. Thei closurei of schools aind thei shift to distaincei leiairning preiseinteid maijor chailleingeis in deiveiloping chairaicteir eiducaition ait Inteigraiteid Islaimic Eileimeintairy Schools (SDIT). This study aiims to eixplorei thei chailleingeis aind innovaitions impleimeinteid in chairaicteir eiducaition ait Inteigraiteid Islaimic Eileimeintairy Schools (SDIT) Peirmaitai Bundai aind Inteigraiteid Islaimic Eileimeintairy Schools (SDIT) Peilitai Khoitul Ummaih in Baindair Laimpung during thei Covid-19 paindeimic. Thei reiseiairch meithod useid is quailitaitivei with ai caisei study aipproaich, involving in-deipth inteirvieiws with teiaicheirs, studeints, aind paireints, ais weill ais ainailysis of school prograim documeintaition. Thei reisults indicaitei thait Inteigraiteid Islaimic Eileimeintairy Schools (SDIT) Baindair Laimpung faiceid vairious chailleingeis, such ais limiteid sociail inteiraiction, difficultieis in aicceissing teichnology, aind thei disruption of sociail aind reiligious aictivitieis. Howeiveir, thei schools succeieideid in deiveiloping seiveirail innovaitions, such ais thei usei of teichnology in onlinei leiairning, projeict-baiseid leiairning, aind increiaiseid collaiboraition with paireints. Thei rolei of paireints wais ailso cruciail in supporting theiir childrein to einsurei thait chairaicteir eiducaition continueid eiffeictiveily, deispitei thei shift to onlinei leiairning. This study concludeis thait ailthough thei paindeimic poseid vairious chailleingeis, it ailso eincouraigeid thei creiaition of ai morei fleixiblei aind aidaiptivei chairaicteir eiducaition modeil thait cain bei aipplieid in thei futurei. Reicommeindaitions airei provideid to streingthein thei collaiboraition beitweiein schools aind paireints in supporting thei deiveilopmeint of studeints' chairaicteir in thei futurei.
Acumulación de doble sanción como forma de garantizar el control externo de la administración pública
Authors: Pedrolli Serretti André 
Published: January 2025

Esta pesquisa analisa como o Supremo Tribunal Federal aborda a relação entre o direito penal e o direito administrativo, especialmente nas situações em que ambos impõem sanções pelos mesmos fatos. Examina-se o fundamento constitucional do direito penal e seu controle de constitucionalidade, considerando que a Constituição é a referência legítima para a intervenção penal em um Estado Democrático de Direito, através de um método jurídico hermenêutico denominado ponderação. Investiga-se o princípio non bis in idem e sua presença na Constituição brasileira, bem como as condições para sua aplicação. Argumenta-se que permitir sanções criminais e administrativas para o mesmo ato é essencial para garantir a transparência no exercício das funções estatais, embora se reconheça que em outros países, como Espanha e Chile, esta acumulação nem sempre é considerada adequada. Isso engendra a necessidade de analisar sua aplicação no contexto brasileiro.
Implementing and Learning from a Summer Research Data Management Training Program for Student Researchers
Authors: Read Kevin B. , Rutley Sarah 
Published: January 2025

Background
This study explores a library-led research data management (RDM) training program at a Canadian post-secondary institution that targeted students participating in summer research assistantships as well as their faculty supervisors. This paper describes the program in detail and shares findings from a student reflection assignment about practicing RDM for the first time.
Methods
The RDM training program included four requirements: attending an introductory RDM session; attending a data management plan (DMP) workshop; submitting a DMP for feedback; and completing a reflection assignment. Where consent was obtained (n=19), reflection assignments were analyzed using a qualitative content analysis approach.
Results
35 faculty supervisors registered 53 students to participate. 62.2% (n=33) of students completed all components of the program. Perceived benefits of completing a DMP included improved project planning, supporting best practices, potential for data reuse, and team communication. Perceived challenges included the inflexibility of DMPs, difficulty populating DMPs, demands on researchers’ time, and lack of long-term utility. 73.6% of students (n=14/19) reported that building a DMP helped them with their summer projects.
Conclusion
Through instruction, practical engagement, and reflection within the context of real-world research, the program supported participants in learning about and practicing RDM, and provided insights for academic librarians who wish to refine or develop training in their local contexts as they continue to navigate emerging expectations from funders and publishers.
Novel simultaneous oil-water separation strategy with Janus membrane via integrating two opposite wettability microfibers
Authors: Xia Yumin , Jin Wenbin , Wan Hai , Zhang Yao , Liang Yuan , Huang Shuohan , Chen Yuwei , Wei Peng , Wang Yanping , He Yong 
Published: January 2025

Abstract

In the realm of oil-water separation, a prevalent issue is the inherent limitation of most materials to exhibit either hydrophilicity or lipophilicity. This singular affinity impedes the seamless separation of light oil/water and water/heavy oil mixtures. Although some materials have been identified to exhibit Janus wettability—encompassing both lipophilic and hydrophilic properties—further refinement of experimental strategies is essential to accommodate the diverse requirements of separating these mixtures. Our research introduces an innovative approach by mechanically grinding fibers to create two microfibers with distinct wettabilities. Subsequently, an interdigital Janus microfiber membrane (IJMM) was crafted through a filtration process. This IJMM demonstrated exceptional efficiency in the continuous separation of the three-phase system involving light oil, water, and heavy oil, achieving average separation rates of 94% for light oil, 96.7% for water, and 93% for heavy oil. This development effectively addresses the challenge of needing to modify conditions for the separation of various oil/water mixtures. Moreover, we formulated a mixed oil (MO) with a density comparable to that of water for separation, which was designed to replicate the non-stratified conditions of oil and water in complex environments. The IJMM was capable of efficiently and simultaneously separating the MO/water mixtures, with average separation efficiencies of 98.7% for MO and 96.7% for water. Consequently, our membrane via integrating two opposite wettability microfibers presents a novel strategy for the continuous and simultaneous separation of light oil/water/heavy oil mixtures, offering promising prospects for oil-water separation in complex applications with non-stratified conditions.
MassCube: a Python framework for end-to-end metabolomics data processing from raw files to phenotype classifiers
Authors: Fiehn Oliver , Yu Huaxu , Ding Jun , Shen Tong , Liu Min , Li Yuanyue 
Published: January 2025

Abstract

Nontargeted peak detection in LC-MS-based metabolomics must become robust and benchmarked. We present MassCube, a Python-based open-source framework for MS data processing that we systematically benchmarked against other algorithms and different types of input data. From raw data, peaks are detected by constructing mass traces through signal clustering and Gaussian-filter assisted edge detection. Peaks are then grouped for adduct and in-source fragment detection, and compounds are annotated by both identity- and fuzzy searches. Final data tables undergo quality controls and can be used for metabolome-informed phenotype prediction. Peak detection in MassCube achieves 100% signal coverage with comprehensive reporting of chromatographic metadata for quality assurance. MassCube outperforms MS-DIAL, MZmine3 or XCMS for speed, isomer detection, and accuracy. It supports diverse numerical routines for MS data analysis while maintaining efficiency, capable for handling 105 GB of Astral MS data on a laptop within 64 minutes, while other programs took 8-24 times longer. MassCube automatically detected age, sex and regional differences when applied to the Metabolome Atlas of the Aging Mouse Brain data despite batch effects. MassCube is available at https://github.com/huaxuyu/masscube for direct use or implementation into larger applications in omics or biomedical research.
The role of unbalanced segmental duplication in sex chromosome evolution in Australian ridge-tailed goannas
Authors: Dobry Jason , Zhu Zexian , Zhou Qi , Wapstra Erik , Deakin Janine E. , Ezaz Tariq 
Published: January 2025

Abstract

Varanids are known for conserved sex chromosomes, but there are differences in the size of the W chromosome among species representing varying stages of sex chromosome evolution. We tested for homology of the ZW sex chromosome system with size differences in varanids among four species from two lineages in Australia, the Odatria and the Gouldii. We found that while DNA sequences of the sex chromosomes are conserved in the species we tested, we also identified a homologous region on an enlarged autosomal microchromosome that shares sequences with the W chromosome in some isolated populations of V. acanthurus and V. citrinus from the Odatria lineage. The enlarged microchromosome was unpaired in all individuals tested and is likely an unbalanced segmental duplication translocated between chromosome 1, the W, and another microchromosome. This suggests an ancient balanced duplication homologous to the W and the terminal region of the long arm of chromosome 1. The most parsimonious explanation is that the duplicated region likely originated on chromosome 1. We hypothesised in our reconstruction that genes and related DNA sequences associated with the sex-linkage group have likely originated on an autosome. Subsequently, the sequences may have undergone duplication and translocation to the W chromosome, followed by the accumulation of lineage specific repeat elements and amplifications on the W at different rates in various lineages. Lastly, these sequences are likely to have undergone duplication and translocation to another autosomal microchromosome. Given the role of segemental duplications and translocations as important evolutionary drivers of speciation in other taxa, our findings provide broader insight into the evolutionary pathway leading to rapid chromosomal and genic divergence of species.