bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review
Authors: Bandopadhyay Shinjini , Mandal Sujata , Ghorai Mimosa , Jha Niraj Kumar , Kumar Manoj , Radha  , Ghosh Arabinda , Proćków Jarosław , Pérez de la Lastra José M. , Dey Abhijit 
Published: February 2023

AbstractCentella asiatica is an ethnomedicinal herbaceous species that grows abundantly in tropical and sub‐tropical regions of China, India, South‐Eastern Asia and Africa. It is a popular nutraceutical that is employed in various forms of clinical and cosmetic treatments. C. asiatica extracts are reported widely in Ayurvedic and Chinese traditional medicine to boost memory, prevent cognitive deficits and improve brain functions. The major bioactive constituents of C. asiatica are the pentacyclic triterpenoid glycosides, asiaticoside and madecassoside, and their corresponding aglycones, asiatic acid and madecassic acid. Asiaticoside and madecassoside have been identified as the marker compounds of C. asiatica in the Chinese Pharmacopoeia and these triterpene compounds offer a wide range of pharmacological properties, including neuroprotective, cardioprotective, hepatoprotective, wound healing, anti‐inflammatory, anti‐oxidant, anti‐allergic, anti‐depressant, anxiolytic, antifibrotic, antibacterial, anti‐arthritic, anti‐tumour and immunomodulatory activities. Asiaticoside and madecassoside are also used extensively in treating skin abnormalities, burn injuries, ischaemia, ulcers, asthma, lupus, psoriasis and scleroderma. Besides medicinal applications, these phytocompounds are considered cosmetically beneficial for their role in anti‐ageing, skin hydration, collagen synthesis, UV protection and curing scars. Existing reports and experimental studies on these compounds between 2005 and 2022 have been selectively reviewed in this article to provide a comprehensive overview of the numerous therapeutic advantages of asiaticoside and madecassoside and their potential roles in the medical future.
BASP1 promotes high glucose‐induced endothelial apoptosis in diabetes via activation of EGFR signaling
Authors: Sun Fengnan , Liu Junwei , Wang Yanzheng , Yang Hongmei , Song Danfeng , Fu Haiyan , Feng Xingxing 
Published: February 2023

AbstractAimsDiabetes mellitus is a common chronic disease of glucose metabolism. Endothelial dysfunction is an early event in diabetes complicated by cardiovascular disease. This study aimed to reveal the expression of BASP1 and its biological roles in endothelial cell dysfunction in diabetes complicated by cardiovascular disease.Materials and MethodsBy analyzing the databases related to diabetes complicated with coronary heart disease, BASP1 was screened out as an upregulated gene. Human umbilical vein endothelial cells (HUVECs) and primary mouse aortic endothelial cells were treated with high glucose to establish cell models of diabetes‐related endothelial dysfunction, and the expression changes of BASP1 were verified by RT‐qPCR, western blot, and immunofluorescence. BASP1 was silenced or overexpressed by siRNA or overexpression plasmid, and its effects on cell migration, apoptosis, tube formation, inflammatory response, and ROS were detected. The possible signaling pathway of BASP1 was found and the mechanism of BASP1 on promoting the progression of endothelial dysfunction was explored using the EGFR inhibitor, gefitinib.ResultsBioinformatics analysis indicated that the expression of BASP1 in patients with diabetes mellitus and concomitant coronary heart disease was increased. High glucose induced the upregulation of BASP1 expression in endothelial cells, and showed a time‐dependent relationship. Silencing of BASP1 alleviated the damage of high glucose to endothelial cells. BASP1 regulated EGFR positively. The promoting effect of BASP1 on endothelial cell apoptosis may be achieved by regulating the EGFR pathway.ConclusionBASP1 promotes endothelial cell injury induced by high glucose in patients with diabetes, which may be activated by activating the EGFR pathway.
High‐resolution phylogenetic analysis reveals long‐term microbial dynamics and microdiversity in phytoplankton microbiome
Authors: Choi Chang Jae , Jauzein Cecile , Erdner Deana L. 
Published: February 2023

AbstractPhytoplankton‐bacteria interactions represent the evolution of complex cross‐kingdom networks requiring niche specialization of diverse microbes. Unraveling this co‐evolutionary process has proven challenging because microbial partnerships are complex, and their assembly can be dynamic as well as scale‐ and taxon‐dependent. Here, we monitored long‐term experimental evolution of phytoplankton‐bacteria interactions by reintroducing the intact microbiome into an axenized dinoflagellate Alexandrium tamarense to better understand microbiome assembly dynamics and how microbiome composition could shift and stabilize over 15 months. We examined host functioning by growth rate, photosynthetic capability, cell size, and other physiological signatures and compared it to associated microbial communities determined by 16S rRNA gene sequences. Our results showed that microbiome reconstitution did not restore the intact microbiome, instead a distinct microbial community shift to Roseobacter clade was observed in the re‐established cultures. In‐depth comparisons of microbial interactions revealed no apparent coupling between host physiology and specific bacterial taxa, indicating that highly represented, abundant taxa might not be essential for host functioning. The emergence of highly divergent Roseobacter clade sequences suggests fine‐scale microbial dynamics driven by microdiversity could be potentially linked to host functioning. Collectively, our results indicate that functionally comparable microbiomes can be assembled from markedly different, highly diverse bacterial taxa in changing environments.
The effect of regional massage performed before blood collection on pain and vital signs in newborns
Authors: Küçüktepe Ayşe , Canbulat Şahiner Nejla 
Published: February 2023

AimThis randomised‐controlled trial aims to examine the effect of regional massage performed before blood collection on pain and vital signs in term newborns.MethodsThe study sample consisted of a total of 96 term newborns, 49 in the experimental group and 47 in the control group, in the neonatal intensive care unit (NICU). Before the blood collection process, those in the experimental group received two (2) minutes of massage on their blood collection region, and their pain levels and vital signs were observed. Data were collected using a newborn information form, an intervention follow‐up form, and the Neonatal Infant Pain Scale (NIPS). Statistical analyses of the collected data included descriptive statistics, Chi‐squared test, independent‐samples t test, paired‐samples t test and Cohen's kappa statistic. A value of P < 0.05 was considered statistically significant.ResultsWhile 51% (n = 49) of the newborns were included in the experimental group, 38.5% (n = 37) were born at the 38th gestational week. Their mean post‐natal age was 4.82 ± 4.04 days. The newborns in the experimental and control groups had similar demographic characteristics and blood collection experiences, and there was no statistically significant difference between them (P > 0.05). The mean crying time in the control group (56.9 ± 25.4 s) was significantly longer than that in the experimental group (30.6 ± 29.3 s) (P < 0.05). The newborns in the experimental group had shorter crying times, lower pain levels and heart rate, and higher oxygen saturation than those in the control group.ConclusionThe regional massage intervention reduced pain in term newborns. Therefore, neonatal nurses can be trained to use massage as an alternative infant care practice.
The Icarus flight of speculation: Philosophers' vices as perceived by nineteenth‐century historians and physicists
Authors: ten Hagen Sjang , Paul Herman 
Published: February 2023

AbstractWhy did nineteenth‐century German historians and physicists habitually warn against vices that they believed philosophers in particular embodied: speculation, absence of common sense, and excessive systematizing? Drawing on a rich array of sources, this article interprets this vice‐charging as a rhetorical practice aimed at delineating empirical research from Naturphilosophie and Geschichtsphilosophie as practiced in the heyday of German Idealism. The strawman of “the philosopher” as invoked by historians and physicists served as a negative model for strongly empiricist scholars committed to virtues like precision, thoroughness, and conscientiousness. In their historical narratives, historians and physicists consistently depicted philosophy either as a relic from the past or as a phase that they had virtuously left behind. This boundary work was central to the self‐positioning of both history and physics, which makes clear that the persona of the philosopher mattered not only to philosophers but also to scholars in adjacent disciplines.
Creativity and genius as epistemic virtues: Kant and earlypost‐Kantianson the teachability of epistemic virtue
Authors: Ziche Paul 
Published: February 2023

AbstractThere is a classical paradox in education that also affects the epistemic virtues: the paradox inherent in the demand to develop general strategies for training persons to be free and creative individuals. This problem becomes particularly salient with respect to the epistemic virtue ofcreativity, the more so if we consider a radical form of creativity, namely,genius. This paper explores a historical constellation in which rigorous claims about the standards for knowledge and morality were developed, along with a highly influential notion of genius: the philosophy of Kant and of immediate post‐Kantian philosophers. The paper shows how in this historical moment came together a new notion of “science,” a theory of “genius” and of virtues, and an analysis of the promises and difficulties inherent in educating a virtuous or creative individual. In this constellation of ideas, there also emerges a potentially fruitful account of how to teach intellectual creativity.
Quantitative Easing and Wealth Inequality: The Asset Price Channel*
Authors: De Luigi Clara , Feldkircher Martin , Poyntner Philipp , Schuberth Helene 
Published: February 2023

AbstractWe assess the impact of the ECB's unconventional monetary policy, specifically of quantitative easing (QE), on the distribution of household wealth in nine euro area countries. For this purpose, we estimate the effects of a QE shock on housing and risky financial asset prices by means of local projections. We then use these estimates to carry out micro‐simulations based on data from the Household Finance and Consumption Survey (HFCS). For the majority of the countries under review, expansionary QE via asset prices leads to net wealth inequality increases when measured using wealth indicators that are sensitive to changes at the tails of the wealth distribution. This finding contrasts with results based on the Gini coefficient which point to an equalizing impact of QE. One‐third of the households in our sample holds neither housing nor financial wealth and is thus not directly affected by QE measures through the asset prices channel.
An early Cambrian polyp reveals a potential anemone‐like ancestor for medusozoan cnidarians
Authors: Zhao Yang , Parry Luke A. , Vinther Jakob , Dunn Frances S. , Li Yu‐Jing , Wei Fan , Hou Xian‐Guang , Cong Pei‐Yun 
Published: February 2023

AbstractCnidarians form a disparate phylum of animals and their diploblastic body plan represents a key step in animal evolution. Cnidarians are split into two main classes; anthozoans (sea anemones, corals) are benthic polyps, while medusozoans (hydroids, jellyfishes) generally have alternating life cycle stages of polyps and medusae. A sessile polyp is present in both groups and is widely regarded as the ancestral form of their last common ancestor. However, the nature and anatomy of the ancestral polyp, particularly of medusozoans, is controversial, owing to the divergent body plans of the extant lineages and the scarcity of medusozoan soft tissues in the fossil record. Here, we redescribe Conicula striata Luo & Hu from the early Cambrian Chengjiang biota, south China, which has previously been interpreted as a polyp, lophophorate or deuterostome. Through re‐examination of the holotype and 51 exceptionally preserved specimens, we show that C. striata possessed features of both anthozoans and medusozoan polyps. A conical, annulated organic skeleton (periderm) fully encasing a polyp is found in fossil and living medusozoans, while a tubular pharynx extending from the mouth into a gut partitioned by c. 28 mesenteries, resembling the actinopharynx of anthozoans. Our phylogenetic analyses recover C. striata as a stem‐group medusozoan, implying that the wealth of medusozoan diversity derived, ultimately, from an anemone‐like ancestor.
Here, there, everywhere: The relational geographies of chemsex
Authors: Di Feliciantonio Cesare 
Published: February 2023

AbstractIn recent years sexualised drug use, usually referred to as chemsex, has become the object of intense media health‐related panic and increasing academic scrutiny. Critical social scientists have challenged pathologising perspectives, analysing the socio‐cultural and political economy dimensions of chemsex. Against the silence of geographers in this emerging field, the paper develops a geographical relational analysis of chemsex, focusing on the experiences of gay men living with HIV in two Italian cities (Bologna; Milan) and Italian gay men living with HIV in three English cities (Leicester; London; Manchester). Demonstrating the constitutive role of place in the practice of chemsex, the paper frames place relationally, that is, as the encounter between here and there, the material and the virtual, imagined geographies and lived spaces. To emphasise the central role of place and geographical knowledge to understand chemsex, the paper builds on ‘weak theory’, as it conceives things as open, entangled, connected and in flux, while focusing on ordinary practices and heterogeneity in more‐than‐human worlds. Showing how chemsex represents an embodied, relational geographical encounter among different human and non‐human actors, places (both physical and digital), imaginations and desires, the paper highlights the role of sexual practices in the relational construction of place‐making, therefore calling for an increased engagement with sex itself within the field of geographies of sexualities.
A Perspective Review of Passive Techniques Applied to Control the Swirling Flow Instabilities From the Conical Diffuser of Hydraulic Turbines
Authors: Tanasa Constantin , Bosioc Alin , Stuparu Adrian , Muntean Sebastian , Susan-Resiga Romeo 
Published: February 2023

Abstract
This paper represents a welcome synthesis of the results obtained by the authors over more than a decade. The reason why such an approach is perfectly justified is found in the novelty of the control techniques of decelerated swirling flows from the conical diffuser of hydraulic turbines. The results presented in this paper refer strictly to the new passive control techniques of the swirling flows instabilities from the conical diffuser of hydraulic turbines. Although the results of these new techniques have been disseminated in various papers, it is difficult to outline an overview from a collection of articles. In addition, a lot of valuable information about modern experimental and numerical investigations is not found in articles that usually distill only the most significant results. Therefore, the present paper achieves a welcome unitary synthesis, useful to specialists in the field of turbomachine hydrodynamics. The reluctance of the turbine manufacturers on active control techniques that use external/additional energy sources led us to the choice of passive control techniques review, especially the ones developed in the last years. The first part of the paper analyzes the specialized literature that includes a variety of passive solutions for mitigating self-induced instabilities of decelerated swirling flow downstream of hydraulic turbines. Such inherent instabilities manifest intensely at far from optimal operating regimes and represent one of the challenges of modern hydraulic turbines. The mitigation of these instabilities is an open problem, so far there are no unanimously accepted technical solutions implemented on prototype turbines. The second part of the paper includes detailed investigations on axial water injection with flow-feedback, but also more recent approaches using adjustable diaphragm in the conical diffuser.
In situRaman observations reveal that the gas fluxes of diffuse flow in hydrothermal systems are greatly underestimated
Authors: Li Lianfu , Luan Zhendong , Du Zengfeng , Xi Shichuan , Yan Jun , Zhang Xin 
Published: February 2023

AbstractReduced gases released from hydrothermal vents supply energy to local deep-marine ecosystems and play an important role in global biogeochemical cycles of sulfur and carbon. The habitable, lower-temperature diffuse flow sites in a hydrothermal system generally have higher biomass than focused flow sites. However, a scarcity of observational data of diffuse flows limits our understanding of the role of volatile gases in these environments. We deployed in situ Raman spectroscopy in the Iheya North hydrothermal field of the mid–Okinawa Trough (East China Sea). A Raman probe inserted directly into hydrothermal vent orifices with temperatures of 30–302 °C collected Raman spectra of hydrothermal fluids. In situ observation data show that the greater volume of diffuse flows results in a flux of volatile gases one to two orders of magnitude higher than that from focused flow environments. This indicates the great potential of diffuse flow for supplying energy and material to hydrothermal systems. The role played by diffuse flow should be reassessed.
Carbon released by sill intrusion into young sediments measured through scientific drilling
Authors: Lizarralde Daniel , Teske Andreas , Höfig Tobias W. , González-Fernández Antonio ,   the IODP Expedition 385 Scientists
Published: February 2023

AbstractThe intrusion of igneous sills into organic-rich sediments accompanies the emplacement of igneous provinces, continental rifting, and sedimented seafloor spreading. Heat from intruding sills in these settings alters sedimentary organic carbon, releasing methane and other gasses. Recent studies hypothesize that carbon released by this mechanism impacts global climate, particularly during large igneous province emplacements. However, the direct impacts of sill intrusion, including carbon release, remain insufficiently quantified. Here, we present results from International Ocean Discovery Program (IODP) Expedition 385 comparing drill-core and wireline measurements from correlative sedimentary strata at adjacent sites cored in Guaymas Basin, Gulf of California, one altered by a recently intruded sill and one unaffected. We estimate 3.30 Mt of carbon were released due to this sill intrusion, representing an order of magnitude less carbon than inferences from outcrops and modeling would predict. This attenuated carbon release can be attributed to shallow intrusion and the high heat capacity of young, high-porosity sediments. Shallow intrusion also impacts sub-seafloor carbon cycling by disrupting advective fluxes, and it compacts underlying sediments, increasing potential carbon release in response to subsequent intrusions.
Melting of fault gouge at shallow depth during the 2008 MW 7.9 Wenchuan earthquake, China
Authors: Wang H. , Li H.B. , Di Toro G. , Kuo L.-W. , Spagnuolo E. , Aretusini S. , Si J.L. , Song S.-R. 
Published: February 2023

AbstractTypical rocks at shallow depths of seismogenic faults are fluid-rich gouges. During earthquakes, on-fault frictional heating may trigger thermal pressurization and dynamic fault weakening. We show that frictional melting, rather than thermal pressurization, occurred at shallow depths during the 2008 MW 7.9 Wenchuan earthquake, China. One year after the Wenchuan earthquake, we found an ~2-mm-thick, glass-bearing pseudotachylyte (solidified frictional melt) in the fault gouges retrieved at 732.6 m depth from the first borehole of the Wenchuan Earthquake Fault Scientific Drilling Project. The matrix of pseudotachylyte is enriched in barium and cut by barite-bearing veins, which provide evidence of co- and postseismic fluid percolation. Because pseudotachylyte can be rapidly altered in the presence of percolating fluids, its preservation suggests that gouge melting occurred in a recent large earthquake, possibly the Wenchuan earthquake. Rock friction experiments on fluid-rich fault gouges deformed at conditions expected for seismic slip at borehole depths showed the generation of pseudotachylytes. This result, along with the presence of a second slip zone attributed to the Wenchuan earthquake at 589.2 m depth, implies that during large earthquakes, frictional melting can occur at shallow depths and that seismic slip can be accommodated by multiple faults. This conclusion is consistent with the evidence from surface faulting that multiple ruptures propagated during the Wenchuan earthquake.
HNF1B variant without hyperglycaemia as a cause of isolated profound hypomagnesaemia
Authors: Vollmer Shobitha , Katzman Per , Londahl Magnus 
Published: February 2023

A young man presented unconscious with severe hyponatraemia, hypokalaemia, hypomagnesaemia and metabolic alkalosis. After 4 months of treatment in hospital, the hypomagnesaemia persisted. The patient had no signs of diabetes mellitus, and radiology showed no abnormalities of the kidneys, pancreas or genitourinary tract. A parenteral magnesium load demonstrated renal wasting with increased fractional urinary excretion of magnesium. Genetic tests for Gitelman as well as Bartter syndromes were negative. However, a wider genetic panel revealed that the patient was heterozygous for a deletion on chromosome band 17q12, encompassing the whole HNF1B gene.This case highlights the importance of considering pathogenic HNF1B variants in isolated profound hypomagnesaemia caused by renal wasting. Pathogenic HNF1B variants may partly mimic hypomagnesaemia found in Gitelman and Bartter syndromes and may be present without other features linked to HNF1B variants, including diabetes mellitus.