bluuebunny/crossref_metadata_2025_split huggingface dataset:
The emotional component of insomnia disorder: A focus on emotion regulation and affect dynamics in relation to sleep quality and insomnia
Authors: Meneo Debora , Samea Fateme , Tahmasian Masoud , Baglioni Chiara 
Published: July 2023

SummaryTheoretical models of insomnia disorder recognise an emotional component in the maintenance of the disorder. Nonetheless, the field of emotions is vast and different processes are involved in psychological well‐being. The present narrative review focusses on emotion regulation and affect dynamics, synthesising some of the most recent and relevant evidence on emotions in relation to the quality of sleep and to insomnia disorder. The literature underlines the close association between impaired sleep quality and difficulties in regulating emotions. Impaired sleep quality is also associated with reduced positive affect and increased negative affect, but little evidence supports a bi‐directional association between affective states and sleep. Affect variability in relation to sleep has been less investigated. Initial evidence suggests that high variability in positive affect has a negative impact on sleep. Neurobiological and behavioural evidence indicates that insomnia disorder is associated with emotion dysregulation, negative affect, and a distinct daily profile of affective states. More research is needed on the affective experience of patients with insomnia disorder, adopting multiple sampling of affect across the day and the week. Understanding how the unfolding of emotions over time interact with sleep alterations may help to improve the tailoring and monitoring of treatments addressing disturbed emotional processes in insomnia disorder.
A systematic review of ecological momentary assessment studies of appetite and affect in the experience of temptations and lapses during weight loss dieting
Authors: Randle Mark , Ahern Amy L. , Boyland Emma , Christiansen Paul , Halford Jason C. G. , Stevenson‐Smith Jack , Roberts Carl 
Published: July 2023

SummaryDietary temptations and lapses challenge control over eating and act as barriers toward successful weight loss. These are difficult to assess in laboratory settings or with retrospective measures as they occur momentarily and driven by the current environment. A better understanding of how these experiences unfold within real‐world dieting attempts could help inform strategies to increase the capacity to cope with the changes in appetitive and affective factors that surround these experiences. We performed a narrative synthesis on the empirical evidence of appetitive and affective outcomes measured using ecological momentary assessment (EMA) during dieting in individuals with obesity and their association with dietary temptations and lapses. A search of three databases (Scopus, Medline, and PsycInfo) identified 10 studies. Within‐person changes in appetite and affect accompany temptations and lapses and are observable in the moments precipitating a lapse. Lapsing in response to these may be mediated through the strength of a temptation. Negative abstinence‐violation effects occur following a lapse, which negatively impact self‐attitudes. Engagement in coping strategies during temptations is effective for preventing lapses. These findings indicate that monitoring changes in sensations during dieting could help identify the crucial moments when coping strategies are most effective for aiding with dietary adherence.
Visual short‐term memory‐related EEG components in a virtual reality setup
Authors: Klotzsche Felix , Gaebler Michael , Villringer Arno , Sommer Werner , Nikulin Vadim , Ohl Sven 
Published: July 2023

AbstractVirtual reality (VR) offers a powerful tool for investigating cognitive processes, as it allows researchers to gauge behaviors and mental states in complex, yet highly controlled, scenarios. The use of VR head‐mounted displays in combination with physiological measures such as EEG presents new challenges and raises the question whether established findings also generalize to a VR setup. Here, we used a VR headset to assess the spatial constraints underlying two well‐established EEG correlates of visual short‐term memory: the amplitude of the contralateral delay activity (CDA) and the lateralization of induced alpha power during memory retention. We tested observers' visual memory in a change detection task with bilateral stimulus arrays of either two or four items while varying the horizontal eccentricity of the memory arrays (4, 9, or 14 degrees of visual angle). The CDA amplitude differed between high and low memory load at the two smaller eccentricities, but not at the largest eccentricity. Neither memory load nor eccentricity significantly influenced the observed alpha lateralization. We further fitted time‐resolved spatial filters to decode memory load from the event‐related potential as well as from its time‐frequency decomposition. Classification performance during the retention interval was above‐chance level for both approaches and did not vary significantly across eccentricities. We conclude that commercial VR hardware can be utilized to study the CDA and lateralized alpha power, and we provide caveats for future studies targeting these EEG markers of visual memory in a VR setup.
Large‐group simulation as a learning method to promote interprofessional collaboration and older adults' patient centered‐care
Authors: Tuononen Tiina A. , Saaranen Terhi , Holopainen Tiina , Suominen Anna Liisa , Silén‐Lipponen Marja 
Published: July 2023

AbstractAimsThis study described the influence of a large‐group simulation on social and health care students´ working life competence concerning interprofessional collaboration (IPC) and patient centered‐care.Methods and resultsThe target group (n = 319) was social and health care students from several different degree programs taking part in a large‐group simulation concerning older people´s oral health as a part of his comprehensive well‐being and health. Data were collected with a questionnaire containing background questions, statements about interprofessional practice and open‐ended questions about learning experiences. The number of respondents was 257, including 51 oral health care students (OHCS). The data were analyzed using descriptive and statistical methods and content analysis.Working life competencies covers the overall social and collaborative skills which health‐care professionals need in their work. They were reported to be improved in IPC and patient‐centered care (PCC). The main described learning experiences in open responses included appreciating different professionals’ competencies and the importance of interprofessional decision‐making, interpersonal communication competence and patient‐centered attitudes in care provision.ConclusionThe large‐group simulation is a good model for educating larger student groups simultaneously and it functioned well in improving understanding of IPC and PCC among older adults.
Evaluating the Influence of Foreign Exchange Policy Regime on the Construction Sector in Nigeria
Authors: Saka Najimu , Moyanga Dorcas Titilayo 
Published: July 2023

In developing economies, foreign exchange policy regime (FEPR) play a critical role in the viability of all sectors of the economy. In Nigeria, the economy is dependent on foreign inputs from contracting services, technology, materials, expatriates, etc. Therefore, this study investigated the impact of FEPR on the performance of the construction sector in Nigeria. To achieve this goal, time series data was extracted from United Nations Statistics Division (UNSD) on the construction sector, gross domestic product (GDP) and FEPR for 50 years spanning from 1970 to 2019. The study uses econometric approach including tests of stationarity and co-integration as well as the generalized method of moment (GMM) to model the relationships between the variables. The study reveals that the 1986 FEPR reform had significant and negative effect on the construction sector output in Nigeria. This implies that the performance of the construction sector is affected by the state of the economy and government policy. This study proves that the foreign exchange policy regime does not significantly influence the construction industry during the period of review. It also ascertained that the development of the construction sector depends more on previous construction outputs and only altered due to oil export shock. Hence, this study recommends that sustainable construction development strategies should be implemented to eliminate construction sector challenges and reduce the effect of foreign exchange rate volatility on the construction sector. Finally, monetary and fiscal policies that can engender sustainable growth and development of the construction sector should be implemented.
Heteroleptic Cobalt Complexes with Abnormally Coordinated N-Heterocyclic Carbene
Authors: Petrov P. A. , Nikolaevskii S. A. , Yambulatov D. S. , Sukhikh T. S. , Starikova A. A. , Kiskin M. A. , Sokolov M. N. , Eremenko I. L. 
Published: July 2023

Abstract
The reaction of cobalt pivalate [Co(Piv)2]n and in situ generated N‑heterocyclic carbene IPrPh (1,3-bis(2,6-diisopropylphenyl)-2-phenylimidazol-4-ylidene) affords heteroligand complexes [Co2(Piv)4-(IPrPh)2] (I), [Co2(Piv)2.8(OtBu)1.2(IPrPh)2] (II), and [Co3(μ3-O)(Piv)4(IPrPh)2] (III). The structures of complexes II·C6H14 and III are determined by X-ray diffraction (XRD) (CIF files CCDC nos. 2216724 and 2216725, respectively). Exchange spin-spin interactions between the magnetic Со2+ ions in the synthesized compounds are estimated by quantum chemical calculations.
Cryptanalysis of quantum private comparison with six-particle maximally entangled states
Authors: Tsai Chia-Wei , Yang Chun-Wei , Wang Chun-Hsiang , Lin Jason 
Published: July 2023

The measurement property of the six-particle maximally entangled state was used by Sun [Mod. Phys. Lett. A 37, 2250149 (2022)] to design a quantum private comparison (QPC) protocol. However, this study points out that the entanglement property of the six-particle maximally entangled state is inconsequential as a security measure; that is, participants waste resources to store the entanglement state and perform the Bell measurement without obtaining any additional security advantage. Although a third party (TP) cannot obtain information regarding the participants’ secret messages through an attack, an attack renders the six-particle entanglement redundant. Accordingly, this study proposed an improved QPC protocol to prevent third-party attacks.
The Politics of Play: Ugo La Pietra's Design Without Ends
Authors: Fardin J. Igor 
Published: July 2023

Abstract
This article investigates the potential of play for design practice and theory. First, drawing on the works of linguist Emile Benveniste and philosopher Giorgio Agamben, I propose a theoretical understanding of play as an act capable of suspending and deactivating means-end relations. Second, I articulate what this deactivating potential of play entails for the field of design through close readings of a series of works by Italian architect, artist, and designer Ugo La Pietra. In doing so, I uncover the politics that this deactivation within design seems to point towards—a politics of play.
Micro-structural white matter abnormalities in new daily persistent headache: a DTI study using TBSS analysis
Authors: Mei Yanliang , Wang Wei , Qiu Dong , Yuan Ziyu , Bai Xiaoyan , Tang Hefei , Zhang Peng , Zhang Xue , Zhang Yaqing , Yu Xueying , Sui Binbin , Wang Yonggang 
Published: July 2023

Abstract
Background
New daily persistent headache (NDPH) is a rare primary headache disorder characterized by daily and persistent sudden onset headaches. The pathogenesis of NDPH remains unclear, and there are few white matter imaging studies related to NDPH. The purpose of this study was to investigate the micro-structural abnormalities of white matter in NDPH and provided insights into the pathogenesis of this disease based on tract-based spatial statistics (TBSS).

Methods
Twenty-one patients with NDPH and 25 healthy controls (HCs) were included in this study. T1 structural and diffusion magnetic resonance imaging (MRI) were acquired from all participants. Differences in the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) between patients with NDPH and HCs were investigated using TBSS analysis.

Results
Significantly decreased FA, increased MD and RD were found in patients with NDPH compared to HCs. White matter regions overlaid with decreased FA, increased MD and RD were found in 16 white matter tracts from the Johns Hopkins University ICBM-DTI-81 White-Matter Atlas and Johns Hopkins University White-Matter Tractography Atlas. Specifically, these white matter regions included the right anterior thalamic radiation (ATR), body of the corpus callosum (BCC), bilateral cingulum, left hippocampal cingulum (CGH), left corticospinal tract (CST), forceps major, fornix, left inferior fronto-occipital fasciculus (IFOF), bilateral inferior longitudinal fasciculus (ILF), left posterior limb of the internal capsule (PLIC), right retrolenticular part of the internal capsule (RPIC), splenium of the corpus callosum (SCC), right superior longitudinal fasciculus (SLF) and left uncinate fasciculus (UF). After Bonferroni correction, there were no correlations between the FA, MD, AD and RD values and the clinical characteristics of patients with NDPH (p > 0.05/96).

Conclusion
The results of our research indicated that patients with NDPH might have widespread abnormalities in the white matter of the brain.
Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer
Authors: Wei Si-Liang , Ye Jing-Jing , Sun Li , Hu Lei , Wei Yuan-Yuan , Zhang Da-Wei , Xu Meng-Meng , Fei Guang-He 
Published: July 2023

Abstract
Background
The gefitinib resistance mechanism in non-small cell lung cancer (NSCLC) remains unclear, albeit exosomal circular RNA (circRNA) is known to possibly play a vital role in it.

Methods
We employed high-throughput sequencing techniques to detect the expressions of exosomal circRNA both in gefitinib-resistant and gefitinib-sensitive cells in this study. The circKIF20B expression was determined in serum exosomes and tissues of patients by qRT-PCR. The structure, stability, and intracellular localization of circKIF20B were verified by Sanger sequencing, Ribonuclease R (RNase R)/actinomycin D (ACTD) treatments, and Fluorescence in situ hybridization (FISH). The functions of circKIF20B were investigated by 5-Ethynyl-20-deoxyuridine (EdU), flow cytometry, Cell Counting Kit-8 (CCK-8), oxygen consumption rate (OCR), and xenograft model. Co-culture experiments were performed to explore the potential ability of exosomal circKIF20B in treating gefitinib resistance. The downstream targets of circKIF20B were determined by luciferase assay, RNA pulldown, and RNA immunoprecipitation (RIP).

Results
We found that circKIF20B was poorly expressed in the serum exosomes of gefitinib-resistant patients (n = 24) and the tumor tissues of patients with NSCLC (n = 85). CircKIF20B was negatively correlated with tumor size and tumor stage. Decreasing circKIF20B was found to promote gefitinib resistance by accelerating the cell cycle, inhibiting apoptosis, and enhancing mitochondrial oxidative phosphorylation (OXPHOS), whereas increasing circKIF20B was found to restore gefitinib sensitivity. Mechanistically, circKIF20B is bound to miR-615-3p for regulating the MEF2A and then altering the cell cycle, apoptosis, and mitochondrial OXPHOS. Overexpressing circKIF20B parental cells can restore sensitivity to gefitinib in the recipient cells by upregulating the exosomal circKIF20B expression.

Conclusions
This study revealed a novel mechanism of circKIF20B/miR-615-3p/MEF2A signaling axis involving progression of gefitinib resistance in NSCLC. Exosomal circKIF20B is expected to be an easily accessible and alternative liquid biopsy candidate and potential therapeutic target in gefitinib-resistant NSCLC.

Graphical Abstract
An Atlas of Variant Effects to understand the genome at nucleotide resolution
Authors: Fowler Douglas M. , Adams David J. , Gloyn Anna L. , Hahn William C. , Marks Debora S. , Muffley Lara A. , Neal James T. , Roth Frederick P. , Rubin Alan F. , Starita Lea M. , Hurles Matthew E. 
Published: July 2023

AbstractSequencing has revealed hundreds of millions of human genetic variants, and continued efforts will only add to this variant avalanche. Insufficient information exists to interpret the effects of most variants, limiting opportunities for precision medicine and comprehension of genome function. A solution lies in experimental assessment of the functional effect of variants, which can reveal their biological and clinical impact. However, variant effect assays have generally been undertaken reactively for individual variants only after and, in most cases long after, their first observation. Now, multiplexed assays of variant effect can characterise massive numbers of variants simultaneously, yielding variant effect maps that reveal the function of every possible single nucleotide change in a gene or regulatory element. Generating maps for every protein encoding gene and regulatory element in the human genome would create an ‘Atlas’ of variant effect maps and transform our understanding of genetics and usher in a new era of nucleotide-resolution functional knowledge of the genome. An Atlas would reveal the fundamental biology of the human genome, inform human evolution, empower the development and use of therapeutics and maximize the utility of genomics for diagnosing and treating disease. The Atlas of Variant Effects Alliance is an international collaborative group comprising hundreds of researchers, technologists and clinicians dedicated to realising an Atlas of Variant Effects to help deliver on the promise of genomics.
Unusual presentation of Pott disease and diagnostic challenges in a resource-limited setting: a case report
Authors: Byamukama Anacret , Acan Moses , Sebikali Mugisha Julius 
Published: July 2023

Abstract
Background
Pott disease is rare and responsible for only 1%–2% of all tuberculosis cases. It poses diagnostic challenges in resource-limited settings due to unusual presentation and limited investigative capacity, resulting in debilitating sequelae if diagnosed late.

Case presentation
We present a case of severe Pott disease of the lumbar spine, with a large paravertebral abscess tracking down to the gluteal region in a 27-year-old Black African Ugandan woman living with human immunodeficiency virus, whose main complaint was right lower abdominal pain. She was initially misdiagnosed from the peripheral clinics as a case of lumbago and later with a psoas abscess. The diagnosis of severe Pott disease was established at the regional referral hospital following an abdominal computed tomography scan, and the patient was appropriately initiated on anti-tuberculosis drugs. However, only abscess drainage and provision of a lumbar corset were possible, with no neurosurgical intervention done on the spine due to financial constraints. Clinical review at 2, 6, and 12 months revealed improvement.

Conclusions
Pott disease may present with non-specific symptoms such as abdominal pain resulting from pressure effects of an expansile cold abscess. This, coupled with limited diagnostic capacity in resource-limited settings; results in significant morbidity and possible mortality. Hence, there is need to train clinicians to increase their index of suspicion and equip health units with basic radiological equipment, such as x-ray, for timely detection and subsequent management of Pott disease.
Tensile Test and Numerical Simulation Investigations on the Mechanical Properties of a New Type of Slightly Curved Arc HRB400 Steel Bars in Mass Concrete
Authors: Gao Li , Zhuang Mei-Ling , Zhu Fangzhi , Sun Chuanzhi , Yang Jun 
Published: July 2023

AbstractThe temperature stress in mass concrete structure is relatively high during construction, which usually leads to temperature cracks. To solve this problem, concrete blocks are usually placed by setting wide slots. Connecting the truncated steel bars at the position of the wide slots by welding or extruding sleeves has many disadvantages. To solve the problem of temperature-induced stress loss, a new type of slightly curved arc HRB400 (SCAHRB400) steel bars was proposed without cutting off the steel bars in this article. Tensile tests and numerical simulations were performed for five types of SCAHRB400 steel bars considering geometric and material nonlinearity. Based on the test results and numerical simulation results, the equivalent stress–strain relationships of SCAHRB400 steel bars were established, and the emergence of the plastic zone of SCAHRB400 steel bars in the tensile process were observed, the tensile properties of SCAHRB400 steel bars were analyzed and discussed. The test results indicate that SCAHRB400 steel bars are prone to local yielding near the crown of large arches and at the connection of horizontal and arc sections. The numerical simulation equivalent stress–strain curves have good regularity. The equivalent stress–strain curves of slightly curved arc HRB400 and HRB335 steel bars have the similar changing law. When the stress is small, the tensile stiffness and compressive axial stiffness of slightly curved arc HRB400 and HRB335 steel bars are similar; when the stress is large, the axial stiffness of SCAHRB400 steel bars is greater than that of slight curved arc HRB335 steel bars. Through test and numerical simulation studies, the theoretical basis can be established for the engineering application of new slightly curved arc steel bars in mass concrete.