bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons
Authors: Kounoupa Zouzana , Tivodar Simona , Theodorakis Kostas , Kyriakis Dimitrios , Denaxa Myrto , Karagogeos Domna 
Published: February 2023

ABSTRACT
Rho GTPases, among them Rac1 and Rac3, are major transducers of extracellular signals and are involved in multiple cellular processes. In cortical interneurons, the neurons that control the balance between excitation and inhibition of cortical circuits, Rac1 and Rac3 are essential for their development. Ablation of both leads to a severe reduction in the numbers of mature interneurons found in the murine cortex, which is partially due to abnormal cell cycle progression of interneuron precursors and defective formation of growth cones in young neurons. Here, we present new evidence that upon Rac1 and Rac3 ablation, centrosome, Golgi complex and lysosome positioning is significantly perturbed, thus affecting both interneuron migration and axon growth. Moreover, for the first time, we provide evidence of altered expression and localization of the two-pore channel 2 (TPC2) voltage-gated ion channel that mediates Ca2+ release. Pharmacological inhibition of TPC2 negatively affected axonal growth and migration of interneurons. Our data, taken together, suggest that TPC2 contributes to the severe phenotype in axon growth initiation, extension and interneuron migration in the absence of Rac1 and Rac3.
A Theoretical Study on Rate Constants of Excited State Proton Transfer Reaction in Anthracene-Urea Derivatives
Authors: Onozawa Shu , Nishimura Yoshinobu , Matsui Toru 
Published: February 2023

Abstract
We elucidate the origin of the two types of observed fluorescence in a complex consisting of nPUA (1-anthracen-n-yl-3-phenylurea; n = 1, 2, 9) and an acetate ion. By calculating the molecular properties related to the proton transfer reaction in the excited state, we clarified a correlation between the acid dissociation constant in the excited state (pKa) in the urea moiety and the rate constant of the excited state proton transfer reaction. The computed pKa suggests that the proton on the anthracenyl group side is transferred in the case of 1PUA and 2PUA, whereas the proton on the phenyl group side is transferred in 9PUA. Low pKa and activation barriers were calculated for 9PUA, which causes the stability of 9PUA due to the absence of the planarity after the proton transfer reaction.
Systematic review: The effectiveness of 6-thioguanine nucleotide-based dose optimisation of thiopurines in the treatment of inflammatory bowel disease
Authors: Mateen Bilal , Patel Mehul , Akobeng Anthony , Gordon Morris , Hayee Bu'Hussain 
Published: February 2023

Introduction: Clinical guidelines highlight the potential utility of metabolite-based thiopurine dose optimisation strategies in inflammatory bowel disease (IBD). The aim of this review was to summarise the evidence of effectiveness and safety of a 6-thioguanine nucleotide (6-TGN) metabolite-based dosing strategy for maintenance of remission using azathioprine or mercaptopurine in Crohn's disease and ulcerative colitis. Methods: We searched the Cochrane central register of controlled trials, EMBASE, clinicaltrials.gov, the WHO international clinical trials registry platform, and relevant grey literature, up to 1 December 2021. Inclusion criteria were: all randomised (active comparator) controlled trials of azathioprine or mercaptopurine used for the purposes of maintenance of remission in Crohn's disease or ulcerative colitis where the dose in the intervention arm was optimised based on 6-TGN metabolite assay results. Studies of any duration were eligible for inclusion, and no age restrictions were applied. Results: No studies met the eligibility criteria for this review. Four randomised controlled studies (two of which are currently underway) were identified that assessed the effectiveness of metabolite-based dose optimisation for thiopurine therapy, but were not eligible either because they did not differentiate between induction and maintenance therapy or because of a lack of an appropriate active comparator. Conclusions: There is no RCT-based evidence for dose optimisation using a 6-TGN metabolite-based dosing strategy for maintenance of remission in Crohn's disease or ulcerative colitis. Where evidence is available from combination induction and maintenance trials, it suggests that such a strategy is no better than weight-based dosing. Cochrane protocol registration: CD014795
FORMATION AND MAINTENANCE OF LOYALTY OF MEDICAL PERSONNEL
Authors: Skripnichenko L. , Thagalizhokova L. 
Published: February 2023

To analyze the areas of formation and maintenance of loyalty of the staff of medical institutions, a survey of employees of organizations was conducted according to the L. Porter loyalty questionnaire and the eNPS methodology.
The study showed that in the organizations under consideration, an average level of loyalty was formed, relying in most cases on the emotional component. To maintain the existing situation, a systematic assessment of loyalty and satisfaction of personnel is required. With a general positive attitude of employees towards the organization, sharply negative assessments were identified, which is a potential problem area.
Staff loyalty is associated with such advantages of the organization as comfortable working conditions and the prestige of the organization, which gives a competitive advantage in the employer market. The results of the study made it possible to formulate a number of practical recommendations for maintaining and increasing employee loyalty in the organization.
FORMING A STUDENT'S PERSONAL BRAND AS A TOOL FOR POSITIONING IN THE LABOR MARKET (PART I)
Authors: Shchegulina Oksana , Purlieva A. , Semenova E. , Ayzhanov V. 
Published: February 2023

The article presents a description and results of a study of the possibilities of using a student’s personal brand for future positioning in the labor market and in professional activities. The purpose of the study was to determine the correspondence between the expectations of students, the need to form a personal brand for employment opportunities and the role of the personal brand of the applicant for the employer. The methodological basis of the study was a critical analysis of scientific literature, secondary data from ongoing studies, a review of expert opinions and primary empirical information necessary to achieve the goal. The first direction of empirical research (part I) in the form of an Internet survey was a survey of students of a higher educational institution in order to determine the attitude of a given social group to the problems of forming and developing a personal brand. The second area of empirical research (Part II) in the form of an online survey was a survey of HRM specialists in order to identify the importance of a student’s (young specialist’s) personal brand in the process of recruitment and professional development for the employer. To comprehend the obtained empirical information, the methods of generalization and comparative analysis were used. The results of the empirical study indicate that there are some differences in the perceptions of the importance of a personal brand among students and HR professionals. According to the authors, the data obtained confirm the disagreements identified at the stage of analysis of expert assessments in public discussions regarding the significance and necessity of forming a student’s personal brand. Despite this, research needs to be continued. Increasing the coverage in terms of the number and geography of student youth, as well as HR specialists, as representatives of the employer, will provide better results.
Mutaciones y utilidad del procedimiento administrativo especial de extensión de la jurisprudencia del Consejo de Estado a terceros por parte de las autoridades en Colombia, del 4 de julio de 1991 al 31 de diciembre de 2013
Authors: Rubio Jácome Víctor Alberto , Pabón Giraldo Liliana Damaris , Yáñez Meza Diego Armando 
Published: February 2023

En Colombia la creación del Procedimiento Administrativo Especial de Extensión de la Jurisprudencia del Consejo de Estado a Terceros por parte de las Autoridades marcó un hito para la tutela administrativa efectiva, dado que a las administraciones públicas también les compete proteger y garantizar derechos en función de concreción del derecho. En este trámite es angular para su aplicabilidad la existencia de una tipología de providencia especial, la sentencia de unificación proferida por el Consejo de Estado. Pasados cerca de diez años de su diseño e implementación, resulta preciso determinar las principales mutaciones que se le han incorporado principalmente por la Ley y secundariamente por la jurisprudencia a través de autos, con posterior traslado de algunas de esas subreglas en la reforma legal del año 2021, entre otras, con el objetivo de alcanzar una mayor utilidad de este bajo un parámetro estructural: conservar en el diseño procesal la competencia sobre la decisión de extensión en las administraciones públicas.
Teniendo en cuenta lo anterior la presente investigación pretende determinar la utilidad del procedimiento en uno de sus momentos de aplicabilidad, es decir, a partir del 4 de julio de 1991 (promulgación de la Constitución Política de 1991) pasando por el 2 de julio de 2012 (entrada en vigencia de la Ley 1437 de 2011) y hasta el 31 de diciembre del año 2013, para con ello poder caracterizar las principales mutaciones del procedimiento administrativo, precisando algunos de sus aspectos críticos y posibles propuestas para futuras reformas legales.
Implementation of Teaching Factory (TEFA) in Vocational School to Improve Student Work Readiness
Authors: Dwijayanthi Kadek Diah , Rijanto Tri 
Published: February 2023

This research aims to find out the influence of teaching factory implementation on student work-readiness at SMKN 2 Singaraja. The type of research used is qualitative descriptive to find out phenomena related to the implementation of teaching factory. Interview, observation, and documentation methods are used to obtain data. Validity of data used in this study is the triangulation of sources. Data analysis is done in a way; (1) Data Reduction, (2) Presentation, and (3) Conclusion Drawing (Verification) after obtaining data on the ground. Results of this study showed that implementation of the teaching factory at SMKN 2 Singaraja has been quite good in terms of facilities, infrastructure, and industry involvement in the planning of TEFA activities. However, the TEFA implementation system implemented is less able to support student’s readiness, so there needs to be learning application models in implementation of TEFA that can improve student’s ability to think critically, and have a positive influence on work readiness supporting factors in students.
Creating Interactive Online Learning Experiences among Secondary School Students in Lagos State, Nigeria.
Authors: Odo Moses 
Published: February 2023

In the recent time teaching and learning is no more confined to face-to-face exercise where the students are mere listeners instead of fully participate in the class activities. The study is on creating interactive online learning experiences among Secondary School students in Lagos State, Nigeria. It was a survey study and the population for the study included all the teaching staff members of all the Public Senior Secondary School in Shomolu Local Government Area. Random sampling technique was used to select 100 teachers who responded to the developed questionnaire. A structured questionnaire containing 40 questionnaire items were developed on four point scales. The response scale for the questionnaire is Strongly Agree (4), Agree (3), Disagree (2) and Strongly Disagree (1). The questionnaire was face validated while the reliability of the test was determined using test re-test procedure. The findings of the indicated that there are number ways which online learning can be made interactive. These ways include: involving feedback, creating interactive activities, Assignments & Breakout groups, exploring other free ICT tools, limiting seat time, good teachers/student relationship, discourage absenteeism, allow few minutes of jokes among students during classroom activities and creating course content that is engaging and encouraging peer. Teachers and students related challenges to effective and interactive online learning include lack of motivation in online learners, technical difficulties with online teaching tools, time-consuming resources, setting and forgetting online learning activities, poor learning outcomes, lack of appropriate devices, poor learning space at home, stress among students, lack of fieldwork and access to laboratories and loneliness. It was recommended that creating interactive online learning experiences among secondary school students in Lagos State, could be through involving feedback, creating interactive activities, assignments and breakout groups, exploring other free ICT tools, limiting seat time and good teachers/student relationship.
Tradisi Baritan di Dusun Palulo Kabupaten Blitar: Kajian Living Hadis
Authors: Izzah Zahrotul , Darmansyah Fadli Azis , Robiâ€™ Rahmat Fithror 
Published: February 2023

The Baritan tradition that occurs in Palulo hamlet, Blitar Regency is one of the traditions carried out by the Javanese people. This research examines the meaning of the Baritan Tradition according to local residents and relates the values ​​contained in it in the study of living hadith. The study of living hadith focuses on the traditional phenomenon of behavior that lives in society which is based on the hadith of the prophet. The research used is descriptive research that focuses on the baritan ceremony for the residents of Palulo Hamlet, Blitar Regency, East Java Province. Information collection methods used are library research, online research, observation or observation, as well as interviews with several informants. Based on this research, information is obtained that describes the interaction of living hadith through the ceremony. The implementation of the Baritan Tradition is an understanding of the values ​​that exist in society which is carried out together. Contribution of ideas, energy, modules related to the sustainability of the baritan ceremony. And the arrival at the Barıtan ceremony is a manifestation of this understanding.
Visions perifèriques i angles morts. La producció poètica dels cossos a través de la mirada: Raquel Santanera, Maria Sevilla i Pol Guasch
Authors: Matas Revilla Meritxell 
Published: February 2023

Aquest article presenta la relació entre la mirada i la corporalitat en les obres de tres poetes en llengua catalana del segle XXI. El text se centra en els vincles amb els afectes, el paper de les xarxes socials i el món digital, l’explotació dels cossos, el desig i la creació d’identitats. Aquests elements permeten formular un marc interpretatiu pels textos i posar-los en relació amb les principals qüestions teòriques preponderants del període, així com fer una radiografia de tres noms cabdals i una reflexió sobre el moment actual i la consolidació i continuïtat d’aquestes temàtiques en la poesia catalana, que s’enriqueix cada cop més amb veus noves i amb més estils, propostes i aproximacions diverses que no deixen d’augmentar.
Safety and effectiveness of self‐managed abortion using misoprostol alone acquired from an online telemedicine service in the United States
Authors: Johnson Dana M. , Michels‐Gualtieri Mira , Gomperts Rebecca , Aiken Abigail R. A. 
Published: February 2023

AbstractObjectivesTo evaluate self‐reported outcomes and serious adverse events following self‐managed medication abortion using misoprostol alone provided from an online service.Study DesignWe conducted a retrospective record review of self‐managed abortion outcomes using misoprostol obtained from Aid Access, an online telemedicine organization serving United States (US) residents, between June 1, 2020, and June 30, 2020. The main outcomes were the proportion of people who reported ending their pregnancy without instrumentation intervention and the proportion who received treatment for serious adverse events.ResultsDuring the study period, 1016 people received prescriptions for misoprostol. We obtained follow‐up information for 610 (60%) of whom 568 confirmed use of the medication and 42 confirmed non‐use. When taking the medication, 96% were at or less than 10 weeks' gestation and 4% were more than 10 weeks. Overall, 88% (95% CI: 84.6–90.2) reported successfully ending their pregnancy without instrumentation intervention. Of the 568 who took the misoprostol, 12 (2%) reported experiencing one or more serious adverse events and 20 (4%) reported experiencing a symptom of a potential complication.ConclusionsSelf‐managed medication abortion using misoprostol provided by an online telemedicine service has a high rate of effectiveness and a low rate of serious adverse events. Outcomes compare favorably to other service delivery models using a similar regimen. As mifepristone continues to be over‐regulated and the 2022 US Supreme Court ruling allows states to severely restrict access to in‐clinic abortion care, this regimen is a promising option for self‐managed abortion in the US.
The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial
Authors: Ramezani Majid , Reisian Mahnaz , Sajadi Hezaveh Zohreh 
Published: February 2023

Objective
We hypothesize that synbiotic supplementation could modulate the intestinal microbiota and subsequently, improve the condition of hypothyroid patients.

Methods
Fifty-six adult hypothyroid patients were recruited to this double-blind, placebo-controlled, randomized clinical trial. The intervention was 10 weeks of synbiotic (500 mg of 109 CFU/g probiotics plus fructo-oligosaccharide, n = 28) compared to placebo (lactose, magnesium stearate, talc, and silicon dioxide, n = 28). Randomization and allocation to trial groups were carried out using random number sequences drawn from https://sealedenvelope.com/. Primary outcomes were serum thyroid stimulating hormone (TSH) and free thyroxine (FT4), and secondary outcomes were depression, quality of life, and blood pressure (BP). P-values< 0.05 were considered statistically significant.

Results
Analysis on 51 patients who completed the trial showed that TSH and depression (p> 0.05) did not change significantly, while serum FT4 significantly increased in both groups (p = 0.03 and p = 0.02 in symbiotic and placebo respectively). A significant decrease in systolic BP occurred only in the synbiotic group (p = 0.05). Significant improvements occurred regarding different domains and areas of quality of life in the crude and adjusted analysis, including perceived mental health (p = 0.02), bodily pain (p = 0.02), general health perception (p = 0.002), and wellbeing (p = 0.002), which were significantly higher in the synbiotic group.

Conclusions
Ten-week supplementation with synbiotic had no favorable effect on depression and TSH, but it improved blood pressure and quality of life in patients with hypothyroidism. More trials are needed to support or reject these findings.

Trial registration
IRCT20210926052583N1, Iranian Registry of Clinical Trials (IRCT), registered October 1st, 2021.
An evaluation of the risk factors associated with implementing projects of health information technology by fuzzy combined ANP-DEMATEL
Authors: Sharifian Roxana , Ghasemi Farzane , Kharazmi Erfan , Farhadi Payam , Monem Hossein , Shokrpour Nasrin 
Published: February 2023

Background
Application of a Clinical Information System (CIS) like Electronic Patient Record (EPR), PACS system and CPOE has turned into one of the most important criteria of priorities of health care systems. The aims of the clinical information system include improving the physicians’ efficiency level, integrating the caring process, and expanding the fuzzy quality of the services offered to patients. Achievement of these benefits in reality is not an easy task, and there are lots of plans in this field which are doomed to failure. About 50% of the implementation plans of clinical information systems in health care organizations have failed, and this trend is significantly affecting industrial countries. Proper implementation of hospital information systems lies in identifying and assessing the relationships among the most important risk factors of fuzzy. The present study aimed to provide an applicable model for identifying, ranking and evaluating the risk factors associated with projects of clinical information technology in hospitals of Shiraz University of Medical Sciences.

Method
This is an applied study which evaluates the risk factors associated with implementation of clinical information technology projects in hospitals of Shiraz Medical Sciences University. The participants consisted of professionals and senior experts of clinical information technology. Fuzzy logic was used in this study. We also applied ANP-DEMATEL combined model with fuzzy procedure to provide the analytic model of the study

Results
According to the study findings, lack of top-executive supports, and unstable organizational environment were the two most important risk factors, while the main organizational factors and technology were also highly important. In addition, the factors associated with technology had the highest influence on the other studied risk factors.

Conclusion
Hospital authorities can benefit from this proposed model to reduce the risk of implementing the projects of clinical information technology and improve the success coefficient of the risk of such projects.