bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of occupational therapy in providing vocational rehabilitation for inflammatory arthritis: A scoping review protocol
Authors: Somerville Susan , Codd Yvonne , Gowran Rosemary Joan 
Published: January 2023

AbstractIntroductionInflammatory arthritis (IA) significantly impacts people's ability to continue in work roles, despite advances in medical management. Employment is acknowledged as important for health and wellbeing. Facilitating work participation and employment reduces social welfare dependence for income, minimising societal cost. Internationally, pathways and processes are developing to maintain people with acquired conditions in the workplace. Occupational Therapy supports this process, with its biopsychosocial approach, giving a framework to consider the complex dynamic of a person's vocational rehabilitation (VR) needs. A scoping review framework was chosen to explore the diverse VR process and emerging focus on Occupational Therapy's role in providing VR for the IA population.MethodsThe methodological framework for scoping reviews will be used to guide the process and structure of the scoping review. A search strategy will be implemented in all the major peer reviewed databases along with grey literature repositories for English language studies. Study selection will use the PRISMA‐ScR flow chart against an agreed eligibility criteria by two independent reviewers. Data extraction from the final selection will be mapped out using tables and a supporting descriptive review reflecting on the original scoping review aim and objectives completed.DisseminationFindings will be disseminated at all levels and in various formats to bring them to the attention of clinicians, researchers and policy makers as VR pathways are established and prioritised for the early IA population.
Comprehensive pelvic muscle assessment: Developing and testing a dual e‐Learning and simulation‐based training program
Authors: Newman Diane K. , Lowder Jerry L. , Meister Melanie , Low Lisa K. , Fitzgerald Colleen M. , Fok Cynthia S. , Geynisman‐Tan Julia , Lukacz Emily S. , Markland Alayne , Putnam Sara , Rudser Kyle , Smith Ariana L. , Miller Janis M. ,   the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium
Published: January 2023

AbstractObjectiveThe Prevention of Lower Urinary Tract Symptoms (PLUS) research consortium launched the RISE FOR HEALTH (RISE) national study of women's bladder health which includes annual surveys and an in‐person visit. For the in‐person exam, a standardized, replicable approach to conducting a pelvic muscle (PM) assessment was necessary. The process used to develop the training, the products, and group testing results from the education and training are described.MethodsA comprehensive pelvic muscle assessment (CPMA) program was informed by literature view and expert opinion. Training materials were prepared for use on an electronicLearning (e‐Learning) platform. An in‐person hands‐on simulation and certification session was then designed. It included a performance checklist assessment for use by Clinical Trainers, who in collaboration with a gynecology teaching assistant, provided an audit and feedback process to determine Trainee competency.ResultsFive discrete components for CPMA training were developed as e‐Learning modules. These were: (1) overview of all the clinical measures and PM anatomy and examination assessments, (2) visual assessment for pronounced pelvic organ prolapse, (3) palpatory assessment of the pubovisceral muscle to estimate muscle integrity, (4) digital vaginal assessment to estimate strength, duration, symmetry during PM contraction, and (5) pressure palpation of both myofascial structures and PMs to assess for self‐report of pain. Seventeen Trainees completed the full CPMA training, all successfully meeting the a priori certification required pass rate of 85% on checklist assessment.ConclusionsThe RISE CPMA training program was successfully conducted to assure standardization of the PM assessment across the PLUS multicenter research sites. This approach can be used by researchers and healthcare professionals who desire a standardized approach to assess competency when performing this CPMA in the clinical or research setting.
Perceptual blindless in nutrition: We are in a critical time to be connected
Authors: Lanuza Fabian , Zamora‐Ros Raul , Petermann‐Rocha Fanny , Andrés‐Lacueva Cristina 
Published: January 2023

AbstractOur health and well‐being are affected by our food systems. The new nutrition reality has been linked to complex food systems, interrelated with several pathways and determinants, including physical, socioeconomic, environmental, and ecological, and lately, has been strongly associated with population health, the increase in chronic diseases, and climate change. We briefly comment on four pillars, namely food environments, food security, food supply, and safety and nutritional epidemiology, all of which are key determinants of food systems. We overview some highlights, challenges, and methodologies with a view to advancing food and nutrition science as an integrated field of research. By modifying food systems, we are able to improve the aging and well‐being of populations and the health of the planet. Trusted science, nutritional education, new scientific‐public communication, integrated policy, investment, food availability, and cultural strategies are all essential for creating better food systems. Perceptual blindness in nutrition must be transformed.
Should we reduce routine surveillance imaging in pediatric germ cell tumors?
Authors: Terenziani Monica , Barretta Francesco , Gattuso Giovanna , Bisogno Gianni , Conte Massimo , Crocoli Alessandro , De Pasquale Maria Debora , Biasoni Davide , Spreafico Filippo , D'Angelo Paolo 
Published: January 2023

AbstractThis paper retrospectively investigated the site and the detection method of relapses in children and adolescents with malignant germ cell tumors enrolled in the TCGM‐AIEOP‐2004 Study and subsequently developed a relapse, in order to evaluate a possible reduction in radiological exposure during follow‐up. Including all malignant cases, serum tumor markers identified a relapse in more than 70% and, according to the selection criteria published by Children Oncology Group in 2018, in more than 90% of cases. These results confirm the importance of serum tumor markers as a relapse detection method, with possible reduction of radiology exams in specific subgroups.
Adequate diagnosis of the cause of Parkinsonism and treatment in an elderly patient with schizophrenia: A case report
Authors: Yoshioka Daisuke , Yamanashi Takehiko , Iwata Masaaki 
Published: January 2023

AbstractBackgroundParkinsonism is frequently observed in patients with schizophrenia, and most patients are diagnosed with drug‐induced parkinsonism. However, comorbidity with idiopathic Parkinson's disease or Parkinson‐plus syndrome is also possible. The pathophysiology and treatment for each of these are entirely different, thus an appropriate diagnosis is required. However, distinguishing them based on clinical symptoms alone is often difficult, and many cases are misdiagnosed. Additionally, Parkinsonism is frequently mistaken for negative symptoms.Case DescriptionWe report a case of 68‐year‐old woman diagnosed with schizophrenia, who was admitted to a welfare center. At approximately age 60, the patient experienced motivation reduction, a loss of appetite, and pain in the extremities. In her mid‐60s, tremor and muscle rigidity appeared; nuclear medicine testing was performed for a detailed examination, resulting in a diagnosis of levodopa‐responsive Parkinson's syndrome. Notably, the patient's parkinsonism and emotional symptoms, which had been considered negative symptoms thus far, improved with levodopa treatment.ConclusionThis case report illustrates the importance of properly diagnosing the cause of parkinsonism in patients with schizophrenia.
Expanded carrier screening: What conditions should we screen for?
Authors: Goldberg James D. , Pierson Summer , Johansen Taber Katherine 
Published: January 2023

AbstractCarrier screening tests reproductive couples for their risk of having children affected by serious monogenic conditions. Carrier screening has historically been offered for certain conditions in high‐risk populations. However, more recent evidence has shown that offering carrier screening to all patients, regardless of their ethnicity, more effectively and equitably identifies at‐risk couples. Coupled with technology that enables screening for a nearly unlimited number of conditions, this expanded carrier screening (ECS) approach is now supported by professional society guidelines. Despite recent recommendations by the American College of Medical Genetics and Genomics to screen all patients who are pregnant or considering pregnancy for 113 conditions, questions remain about what conditions should be included on a core ECS panel. Here, we briefly review the history of carrier screening and guidelines on criteria for panel design. We then suggest which of these criteria are most critical, as well as thresholds to identify which conditions meet these criteria. Based on these interpretations, we recommend a core panel of 64 conditions that would identify the vast majority of at‐risk couples. Widespread adoption of a core panel such as this would result in a marked improvement in the number of patients currently receiving comprehensive carrier screening.
Restrictive resuscitation in patients with sepsis and mortality: A systematic review and meta‐analysis with trial sequential analysis
Authors: Reynolds Paul M. , Stefanos Sylvia , MacLaren Robert 
Published: January 2023

AbstractStudy ObjectiveAlthough fluid resuscitation is recommended by the Society of Critical Care Medicine Surviving Sepsis Campaign Guidelines, risks of volume overload persist.The objective of this systematic review is to assess the effects of a restrictive fluid resuscitation approach in the septic patient both during and after the initial resuscitation period (30  ml/kg).DesignA systematic review and meta‐analysis with trial sequential analysis (TSA) of randomized controlled trials was conducted. Two blinded reviewers independently assessed and included studies that evaluated adult patients with sepsis involving a comparator group with an effective restrictive fluid resuscitation approach. The primary outcome was mortality. Secondary outcomes included rates of acute kidney injury (AKI), renal replacement therapy (RRT), ventilator days, intensive care unit (ICU) and hospital length of stay (LOS), duration of vasopressor therapy, and limb (or digital) ischemia.SettingPubMed and Medline databases were queried for the search.PatientsA total of eight trials in 2375 patients were included.InterventionEffective restrictive fluid resuscitation compared with standard of care.Measurements and Main ResultsThe risk of bias was high in six studies and low in two studies, and all studies implemented fluid restriction after a 30‐ml/kg infusion of fluids. Fluid restriction did not significantly reduce mortality in all studies compared to usual care (37% vs. 40% with usual care; risk ratio [RR] 0.90, 95% confidence interval [CI] 0.76–1.06, p = 0.23, I2 = 24%) or by TSA findings. There were no significant differences in rates of AKI or RRT (5 studies), LOS in ICU (4 studies) or hospital (3 studies), duration of vasopressor therapy (6 studies), or incidence of limb or digital ischemia (3 studies). However, fluid restriction significantly reduced ventilator days as evaluated in seven studies (mean difference − 1.25 days, 95% CI −1.92 to −0.58  days, p = 0.0003, I2 = 90%).ConclusionThis study demonstrated that a restrictive resuscitation strategy in sepsis resulted in no difference in mortality but may reduce ventilator days. Larger randomized trials are required to determine the optimal management of fluids in patients with sepsis.
Extrusion for pharma applications: An update
Authors: Gallas Maël , Boulet Pascal , de Margerie Victoire 
Published: January 2023

AbstractThis paper aims to give an overview of our current research and development on hot‐melt extrusion (HME) for pharmaceutical formulation and drug delivery. Unfortunately, a large percentage of marketed drugs (40%) and those in the development pipeline (90%) are poorly water soluble. We use a few examples to show that solubility of APIs can be drastically improved by using HME to mix them with different biocompatible polymers and playing with the various process parameters (extrusion temperature, screw speed, screw configuration, etc.). The advantages of this technique are then presented as well as the further development needed to make this process fully industrial for pharmaceutical purposes.
Combination of size‐exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma‐derived extracellular vesicles
Authors: Wang Yaojie , Zhang Ying , Li Zhi , Wei Sisi , Chi Xiuping , Yan Xi , Lv Huilai , Zhao Libo , Zhao Lianmei 
Published: January 2023

AbstractExtracellular vesicles (EVs) are lipid membrane vesicles released by live cells that carry a variety of biomolecules, including nucleic acids, lipids, and proteins. Recently, proteins in plasma‐derived EVs have emerged as novel biomarkers with essential functions in the diagnosis and prognosis of human diseases. However, the current methods of isolating EVs from plasma often lead to coisolated impurities in biological fluids. Therefore, before performing any research protocol, the process of extracting EVs from plasma for proteomic analysis must be optimized. In this study, two EV isolation strategies, size exclusion chromatography (SEC) and SEC combined with ion exchange adsorption (SEC + IEA), were compared in terms of the purity and quantity of protein in EVs. Our results demonstrated that, compared to single‐step SEC, SEC combined with IEA could produce plasma‐derived EVs with a higher purity by decreasing the abundance of lipoprotein. Additionally, with MS analysis, we demonstrated that the combination approach maintained the stability and improved the purity of EVs in many plasma samples. Furthermore, by combining SEC with IEA, more cancer‐associated proteins were detected in the plasma of various cancer samples.
Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma
Authors: Hong Han , Chen Xi , Wang Honggang , Gu Xiangqian , Yuan Yin , Zhang Zixiang 
Published: January 2023

AbstractHepatocellular carcinoma (HCC), the most common type of primary liver cancer, often metastasizes to the lungs. The implications of lysine lactylation (Kla), a recently identified histone post‐translational modification (PTM), in the pathology of HCC remain unclear. Here, we report the first proteomic survey of this specific modification in HCC (with no metastasis during 3 years of follow‐up), normal liver tissues, and lung metastasis samples of HCC. Of the 2045 modification sites detected on 960 proteins, 1438 sites on 772 proteins contained quantitative information. Subsequently, we analyzed the differentially modified proteins among the different groups. Differentially lactylated proteins were found to be involved in several biological processes, including‐but not limited to‐amino acid metabolism, ribosomal protein synthesis, and fatty acid metabolism. In addition, we identified numerous highly valuable lactate‐modified proteins from the literature. Among them, we verified the lactate modification levels of the following two tumor‐related proteins and obtained similar results: USP14 and ABCF1. These two modified proteins will be further investigated in our future studies. This paper is the first report on the lactylome of HCC and it provides a reliable foundation for further research on Kla in HCC.
Relationship between enhancement of PEDOT:PSS conductivity by solvent treatment and PSS chain reorganization
Authors: Tounakti Chaima , Decorse Philippe , Kouki Fayçal , Lang Philippe 
Published: January 2023

AbstractThe treatment of water‐soluble PEDOT:PSS copolymer film by DMSO or DMF considerably enhances its electrical conductivity. The mechanism leading to a new molecular conformation in the PEDOT:PSS layer was investigated by in situ ATR, PM‐IRRAS and XPS spectroscopies. The release of PSS chains containing excess [Na+, (−Φ‐SO3−)‐] and (−Φ‐SO3H)‐] moieties by the solvent treatment and the implications of this process are discussed. By comparison with a NaPSS/HPSS adduct, the essential role of the conformational reorganization of the poly(styrene sulfonic/sulfonate) chains via hydrogen bonds between SO3H functions is demonstrated. Residual water molecules play a fundamental role both in the removal of excess sulfonates or sulfonic groups, the separation of the (Na, H, PSS) chains, which can then be extracted, and the establishment of the suitable PEDOT conformation.
Effects of the Jokela type of spinal muscular atrophy‐related G66V mutation on the structural ensemble characteristics of CHCHD10
Authors: Alici Hakan , Uversky Vladimir N. , Kang David E. , Woo Junga Alexa , Coskuner‐Weber Orkid 
Published: January 2023

AbstractThe G66V pathological variant of the coiled‐coil‐helix‐coiled‐coil‐helix domain‐containing protein 10 (CHCHD10), mitochondrial, plays a role in Jokela type spinal muscular atrophy. The wild‐type and G66V mutant‐type CHCHD10 proteins contain intrinsically disordered regions, and therefore, their structural ensemble studies have been experiencing difficulties using conventional tools. Here, we show our results regarding the first characterization of the structural ensemble characteristics of the G66V mutant form of CHCHD10 and the first comparison of these characteristics with the structural ensemble properties of wild‐type CHCHD10. We find that the structural properties, potential of mean force surfaces, and principal component analysis show stark differences between these two proteins. These results are important for a better pathology, biochemistry and structural biology understanding of CHCHD10 and its G66V genetic variant and it is likely that these reported structural properties are important for designing more efficient treatments for the Jokela type of spinal muscular atrophy disease.
Bayesian hierarchical models for adaptive basket trial designs
Authors: Chen Chian , Hsiao Chin‐Fu 
Published: January 2023

AbstractBasket trials evaluate a single drug targeting a single genetic variant in multiple cancer cohorts. Empirical findings suggest that treatment efficacy across baskets may be heterogeneous. Most modern basket trial designs use Bayesian methods. These methods require the prior specification of at least one parameter that permits information sharing across baskets. In this study, we provide recommendations for selecting a prior for scale parameters for adaptive basket trials by using Bayesian hierarchical modeling. Heterogeneity among baskets attracts much attention in basket trial research, and substantial heterogeneity challenges the basic assumption of exchangeability of Bayesian hierarchical approach. Thus, we also allowed each stratum‐specific parameter to be exchangeable or nonexchangeable with similar strata by using data observed in an interim analysis. Through a simulation study, we evaluated the overall performance of our design based on statistical power and type I error rates. Our research contributes to the understanding of the properties of Bayesian basket trial designs.
Impact of pretransplant asplenia vaccination on anti‐A/B antibody titers in prospective ABO incompatible kidney transplant recipients
Authors: Bongetti Elisa , Sandrin Mauro S. , Mulley William R. 
Published: January 2023

AbstractBackgroundAsplenia vaccination is employed before ABO‐incompatible (ABOi) transplantation in case splenectomy is needed. Pneumococcal vaccines have been reported, in different patient groups, to increase anti‐A/B titers, through cross‐reactivity to shared polysaccharide epitopes. We investigated the impact of pretransplant asplenia vaccinations on anti‐A/B antibody titers in prospective ABOi renal transplant recipients.MethodsPublished asplenia vaccine microbial structures were reviewed to assess expression of A/B antigens. All patients who underwent ABOi transplantation at Monash Medical Centre with anti‐A/B titers taken either side of asplenia vaccination were included in a retrospective cohort study between 2007 and 2021. Patients with paired titers without intervening vaccination were included as controls. Paired titers were compared within groups.ResultsA and B antigens were found to be expressed by vaccine specific pneumococcal serotypes. Thirty‐nine ABOi renal transplant recipients received vaccination including at least one pneumococcal vaccine. The most common donor to recipient combination was A1 to O. The median pre‐ and postvaccination anti‐A/B titers were 1:32 and there was no significant change in titers following vaccination (median change in titer 0 dilutions, range –2 to 3, P = 0.43). The same findings were apparent in the control group (n = 20). There was no significant change in titer by donor blood group or vaccine type. No transplants were canceled or delayed by a rise in anti‐A/B titers postvaccination.ConclusionPneumococcal vaccination had no clinically relevant impact on anti‐A/B titers before ABOi transplantation in this cohort. These results provide reassurance regarding the safety of asplenia vaccination before ABOi transplantation.
Real‐time fundus reconstruction and intraocular mapping using an ophthalmic endoscope
Authors: Zhou Dongbo , Takeyama Hayato , Nakao Shintaro , Sonoda Koh‐Hei , Tadano Kotaro 
Published: January 2023

AbstractBackgroundRobotic ophthalmic endoscope holders allow surgeons to execute dual‐hand operations in eye surgery. To prevent needle‐like endoscopes from invading the retina when moving, surgeons expect visual and real‐time information about the relative special relationship between the endoscope and fundus.MethodsThis study develops a real‐time fundus reconstruction method. First, using deep learning, the method estimates the distance between the fundus part corresponding to every pixel of the RGB endoscopic image and the endoscope. Then, by combining the estimated distance with the kinematics of a robotic holder, the point cloud representing the present fundus area is generated, and by which the size and position of the eyeball are estimated.ResultsThis method shows a real‐time frequency of 10 Hz, which is robust to eyeball movement. The error of fundus reconstruction is about 0.5 mm, and the error of eyeball estimation is about 1 mm.ConclusionUsing this fundus reconstruction method can map the position of the endoscope inside the eyeball when using a robotic endoscope holder in eye surgery. The overall accuracy level meets the ophthalmologists' accuracy requirements of ophthalmologists.
Adaptive control for unknown HOFA nonlinear systems without overparametrization
Authors: Liu Cungen , Liu Xiaoping , Wang Huanqing , Zhou Yucheng , Gao Chuang 
Published: January 2023

SummaryThe problem of adaptive control is investigated for unknown mixed high‐order fully actuated (HOFA) nonlinear systems. To deal with the parametric uncertainties, the tuning function is utilized to design an adaptive update law without parameter overestimation. Based on the full‐actuation feature of HOFA nonlinear systems and Lyapunov stability theory, an adaptive controller is constructed and its stability is analyzed. Finally, the effectiveness of the control strategy is verified by simulation results.