bluuebunny/crossref_metadata_2025_split huggingface dataset:
ИЗРАЗЦЫ МАВЗОЛЕЯ АЙША БИБИ В СОБРАНИИ ЦЕНТРАЛЬНОГО ГОСУДАРСТВЕННОГО МУЗЕЯ РЕСПУБЛИКИ КАЗАХСТАН.
Authors: Торежанова Набира , Кулиш Алексей 
Published: March 2023

Аннотация. В статье рассматриваются изразцы, относящиеся к мавзолею Айша биби вблизи г. Тараза. Датировка изразцов, как и самого мавзолея, по-прежнему остается достаточно спорной. После обработки и описания части плиток из собрания Центрального Государственного Музея Республики Казахстан становятся понятны новые черты и детали, важные для решения вопросов хронологии и применения отдельных декоративных элементов в постройке. Местная таразская школа изготовления изразцов складывается в домонгольское время, в XI-XII вв, но некоторые изразцы имеют достаточно поздние черты XIII-XIV вв. Можно предположить, что традиции, приемы создания архитектурного декора и декоративных элементов не исчезают после монгольского завоевания Тараза, а получают дальнейшее развитие.
Материал и методы исследования: Материалом исследования послужила коллеция облицовочных изразцов мавзолея Айша биби из археологического фонда ЦГМ РК. Методологическую основу исследования составили принципы историзма, объективности и системный подход, который позволил объединить различные методы анализа и синтеза. В данной статье были использованы историко-сравнительный, системно-аналитический и статистический методы, которые обеспечили решение поставленных задач.
AN OVERVIEW OF THE GOLDEN HORDE STUDIES AND THE PLACE OF GENGHIZNAME AND SHIBANNAMES AS NATIVE SOURCES IN THE GOLDEN HORDE STUDIES
Authors: Gündoğdu Abdullah 
Published: March 2023

Abstract. Studies on the empire of Genghis are becoming increasingly important not only for understanding the Late Middle Ages of Eurasia, but also for its contemporary periods. In the past two centuries, in connection with the historical importance of Eastern Europe and Inner Asia, a great accumulation has been revealed in studies that reveal the location of the four nations that make up this vast empire, especially the Jochi Ulus.
The oral history tradition, on which the Turk peoples are based, has developed in two branches as Oguzname and Genghizname, harmonizing with the historical tradition of China, then Iran and Islam. Works in Persian and Turkish languages are integrated with Islamic traditions. This historiography tradition forms the basis of the Turkic states' conceptions of dominance. These are the mythology of the Turkic peoples, that is, in a sense, the stenography of prehistory or times that history has not recorded.
TRADITIONS OF THE KAZAKHS ASSOCIATED WITH A PREGNANT WOMAN, CHILDBIRTH AND UPBRINGING (COMPARATIVE ANALYSIS WITH SOME OTHER TURKIC PEOPLES)
Authors: Tynaikulova Moldir 
Published: March 2023

Abstract. The article uses data collected by the author from all over the country. Based on the available data and were divided the Kazakh system of rituals associated with a pregnant woman, her childbirth and upbringing into three main stages: prenatal rites; childbirth customs; postnatal customs. The study revealed that the customs of the Kazakh people are connected with the customs of neighboring peoples, including the Turkic-speaking peoples of Siberia and Central Asia. In addition to the origin of these customs, their semantic meaning was analyzed.
The analysis of customs related to a pregnant woman, given in the article, makes it possible to identify the criteria that influenced and influence the position of a woman in the family and society, raising or lowering her status.
Materials and methods: in ethnographic studies, information about Kazakh customs related to childbirth is extremely rare, so the article materials are based on the authentic personal experiences of the author.
The main principles of the study were differentiated using several methods. The first, comparative-historical method: customs were studied depending on certain features (the time and place of the custom, the composition and number of participants, the main custom actions, the objects used in the custom, the meaning of the custom), and on the basis of them, common and special features were determined in the historical sequence. Second, the method of regularity: to consider the custom as the main component of the traditional worldview and system of life forms. Third, the interdisciplinary method: data from disciplines related to ethnography (linguistics, folklore studies, religious studies) were used to identify stable and changing elements of the custom.
In the course of the work, methods of observation and communication, widely used in the world sociological and ethnological sciences, were also used. The analysis of the traditions of the Kazakh people related to the birth of children by comparing them with the customs of the peoples of Siberia and Central Asia contributed to the differentiation of their genetic and cultural commonality. In the differentiation of the topic from a new point of view, the principles of objective and critical analysis and critical study developed at the present stage were the main ones. Problem-chronological, comparative-historical approaches were also used. In particular, the systematization of comparative data served as the basis for determining the relationship of an ethnographic group with an ethnically related group and the consequences of its influence.
Beretning om Tidsskrift.dk og ebooks.au.dk i 2022
Authors: Fogtmann-Schulz Alexandra , Boserup Thestrup Jesper , Iversen Rie Karen Marie 
Published: March 2023

I 2022 har tidsskrift.dk været en del af Det Kgl. Biblioteks Open Science strategi. Arbejdet i forbindelse med Det Kgl. Biblioteks publiceringsservice har i 2022 været præget af en opgradering af Open Journal Systems (OJS) serveren og Open Monograph Press (OMP) serveren samt den løbende drift af de to servere.
Det Det Kgl. Bibliotek gennemførte i 2022 i samarbejde med Aalborg Universitetsbibliotek, CBS Bibliotek og Directory of Open Access Journals (DOAJ) et projekt for at få optaget flere danske Open Access (OA) tidsskrifter i DOAJ.Der blev udarbejdet nye brugervejledninger, gennemført opdateringer og afholdt vejledning og support til tidsskrifterne.
A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies
Authors: Hunniford Victoria T , Grudniewicz Agnes , Fergusson Dean A , Montroy Joshua , Grigor Emma , Lansdell Casey , Lalu Manoj M ,   On behalf of The Canadian Critical Care Translational Biology Group
Published: March 2023

Background:Multicentric approaches are widely used in clinical trials to assess the generalizability of findings, however, they are novel in laboratory-based experimentation. It is unclear how multilaboratory studies may differ in conduct and results from single lab studies. Here, we synthesized the characteristics of these studies and quantitatively compared their outcomes to those generated by single laboratory studies.Methods:MEDLINE and Embase were systematically searched. Screening and data extractions were completed in duplicate by independent reviewers. Multilaboratory studies investigating interventions using in vivo animal models were included. Study characteristics were extracted. Systematic searches were then performed to identify single lab studies matched by intervention and disease. Difference in standardized mean differences (DSMD) was then calculated across studies to assess differences in effect estimates based on study design (>0 indicates larger effects in single lab studies).Results:Sixteen multilaboratory studies met inclusion criteria and were matched to 100 single lab studies. The multicenter study design was applied across a diverse range of diseases, including stroke, traumatic brain injury, myocardial infarction, and diabetes. The median number of centers was four (range 2–6) and the median sample size was 111 (range 23–384) with rodents most frequently used. Multilaboratory studies adhered to practices that reduce the risk of bias significantly more often than single lab studies. Multilaboratory studies also demonstrated significantly smaller effect sizes than single lab studies (DSMD 0.72 [95% confidence interval 0.43–1]).Conclusions:Multilaboratory studies demonstrate trends that have been well recognized in clinical research (i.e. smaller treatment effects with multicentric evaluation and greater rigor in study design). This approach may provide a method to robustly assess interventions and the generalizability of findings between laboratories.Funding:uOttawa Junior Clinical Research Chair; The Ottawa Hospital Anesthesia Alternate Funds Association; Canadian Anesthesia Research Foundation; Government of Ontario Queen Elizabeth II Graduate Scholarship in Science and Technology
Detection of protein, starch, oil, and moisture content of corn kernels using one-dimensional convolutional autoencoder and near-infrared spectroscopy
Authors: Cataltas Ozcan , Tutuncu Kemal 
Published: March 2023

Background
Analysis of the nutritional values and chemical composition of grain products plays an essential role in determining the quality of the products. Near-infrared spectroscopy has attracted the attention of researchers in recent years due to its advantages in the analysis process. However, preprocessing and regression models in near-infrared spectroscopy are usually determined by trial and error. Combining newly popular deep learning algorithms with near-infrared spectroscopy has brought a new perspective to this area.

Methods
This article presents a new method that combines a one-dimensional convolutional autoencoder with near-infrared spectroscopy to analyze the protein, moisture, oil, and starch content of corn kernels. First, a one-dimensional convolutional autoencoder model was created for three different spectra in the corn dataset. Thirty-two latent variables were obtained for each spectrum, which is a low-dimensional spectrum representation. Multiple linear regression models were built for each target using the latent variables of obtained autoencoder models.

Results
R2, RMSE, and RMSPE were used to show the performance of the proposed model. The created one-dimensional convolutional autoencoder model achieved a high reconstruction rate with a mean RMSPE value of 1.90% and 2.27% for calibration and prediction sets, respectively. This way, a spectrum with 700 features was converted to only 32 features. The created MLR models which use these features as input were compared to partial least squares regression and principal component regression combined with various preprocessing methods. Experimental results indicate that the proposed method has superior performance, especially in MP5 and MP6 datasets.
Comprehensive analysis of COMMD10 as a novel prognostic biomarker for gastric cancer
Authors: Zhao Wenfang , Lin Jiahui , Cheng Sha , Li Huan , Shu Yufeng , Xu Canxia 
Published: March 2023

Background
COMMD10 has an important role in the development of certain tumors, but its relevance to gastric cancer (GC) is unclear. The purpose of this study is to investigate the difference of COMMD10 expression in gastric adenocarcinoma (STAD) and analyze the correlation between COMMD10 expression and prognosis of STAD patients.

Methods
The expression levels of COMMD10 between STAD and normal tissues were explored using the The Cancer Genome Atlas (TCGA) database. In addition, the expression of COMMD10 in GC was further validated by immunohistochemistry (IHC) staining, qRT-PCR and Western blot. Dot blot experiments were used for exploring m6A expression levels in tissues with high and low COMMD10 expression. Kaplan–Meier analysis and COX regression analysis were used to explore the relationship between COMMD10 and STAD prognosis. A nomogram was constructed to predict the survival probability of STAD patients. GO and KEGG functional enrichment of COMMD10-related genes were performed. The Corrlot software package was used to analyze the correlation between COMMD10 expression levels and m6A modifications in STAD. An analysis of immune infiltration based on the CIBERSOFT and the single-sample GSEA (ssGSEA) method was performed.

Results
COMMD10 expression was significantly associated with multiple cancers, including STAD in TCGA. COMMD10 expression was elevated in STAD cancer tissues compared to paracancerous tissues. COMMD10 upregulation was associated with poorer overall survival (OS), clinical stage, N stage, and primary treatment outcome in STAD. Functional enrichment of COMMD10-related genes was mainly involved in biological processes such as RNA localization, RNA splicing, RNA transport, mRNA surveillance pathways, and spliceosomes. The dot blot experiment showed that m6A levels were higher in cancer tissues with high COMMD10 expression compared with paracancerous tissues. COMMD10 was significantly correlated with most m6A-related genes. COMMD10 was involved in STAD immune cells infiltration, correlated with macrophage cells expression.

Conclusion
High COMMD10 expression was significantly associated with poor prognosis in STAD patients, and its functional realization was related to m6A modification. COMMD10 involved in STAD immune infiltration.
The Impact of Intellectual Property Quality on Economic Development: Insights from Jiangsu Province
Authors: Fan XuJia , Zhang Tao 
Published: March 2023

Aims: This paper gets rid of the limitation of patent quantity of intellectual property, strengthens people's protection on the quality of intellectual property, and makes people realize that intellectual property will eventually be transformed into productivity and have an impact on economic development.
Study Design: The quality of intellectual property is measured through three dimensions: patent market (economic) quality, patent technology quality and patent law quality
Methodology: Based on the essence of patent quality, this paper defines and divides the concept, evaluation system and research index of intellectual property quality, and analyzes the internal relationship and influence mechanism between intellectual property quality and economic development.
Results: The quality of intellectual property is positively correlated with economic development.
Conclusion: The research conclusion puts forward new requirements for the transformation efficiency of intellectual property in the technology market of Jiangsu Province. The ultimate destination of patent invention is to serve the society and promote productivity. It is not only necessary to pay attention to the protection of the "source" of intellectual property, but also to enhance the agglomeration effect of intellectual property in the "economic estuary". It is of great practical significance to realize both "quality" and "quantity" of intellectual property for strengthening the construction of intellectual property, perfecting intellectual property system and promoting economic development.
.NET Tools for Software Development: Tool Selection, Key Benefits of .NET Web Applications
Authors: Smorgun Mykola 
Published: March 2023

Aims: This report analysis the top 5 .NET tools that can be used to develop website and software.
Study Design: We have shortlisted the 5 .NET tools that can be used to design and implement website and software.
Methodology: According to Microsoft, .NET is a software-based approach for integrating information, users, technologies, and devices, and it encompasses everything that an organization requires to build and deploy an integrated data architecture: servers used to host services; development tools; and apps that utilize them. We have selected Web essential for Visual studio, Resharper, Ncrunch, NuGet and Elmah tools.
Results: The exposed qualities connect to modern emerging techniques such as components, allocation, software and services, and online redirection. As a result of the available options, .NET is recognized as one of the most extensively used software development platforms. The framework .NET's of devices and technologies as well as their optimal usage in practice, need knowledge with its tool set.
Conclusion: The NET-framework offers a variety of software types, with a focus on producing apps for Windows, mobile devices, and the Internet. Windows applications can be terminal (text-based) or graphical, including drivers, libraries, and services. Applications for mobile devices are created for smartphones and tablets. ASP.NET web services and web applications written for the Internet.
Blood Pressure and Heart Rate Responses in Young Nigerian Women during Passive and Zero-Resistance Active Exercise Tests Compared to Non-Obese Control
Authors: Winifred Chukwukaeme Chidinma , Uchechukwu Dimkpa , Eluemunor Nwaefulu Kester , Frances Okwuonu Ifeoma , Jacinta Umezulike Anuli 
Published: March 2023

Aim: To compare blood pressure (BP) and heart rate (HR) responses to passive and unloaded active leg movements and the neural control mechanisms between obese young female adults and their non-obese control.
Study Design: A case control study.
Place and Duration of Study: Department of Human Physiology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria, between July 2015 to January 2016.
Methodology: Thirty normotensive young women were randomly selected for this study and assigned into two groups- obese (n =15) and non-obese (n =15). Subjects performed a sub-maximal ergometer exercise test. Each group performed separate bouts of 5-minutes passive and unloaded active cycling exercises. BP and HR were recorded at baseline and during the two exercise conditions. All statistics were done using SPSS (version 25). Comparative analyses were done using independent sample t-test (for normally distributed data) or Mann Whitney-U (for abnormally distributed data) or a two-way analysis of variance (ANOVA).
Results: The obese women indicated significantly (p < 0.05) higher HR, systolic BP, diastolic BP, mean arterial pressure (MAP), and rate pressure product (RPP) compared with the non-obese control at baseline, during passive and unloaded active exercise conditions. The magnitude of increase (Δ) in BP from baseline to passive leg movement and ΔHR elicited from passive to unloaded active movement showed no significant differences between the two groups.
Conclusions: The higher mean BP and HR observed in the obese women, at baseline, during passive and unloaded active cycle movements were attributed to poor cardio-respiratory fitness and greater myocardial metabolic demand imposed by excessive adipose tissue. The lack of significant differences in ΔBPbaseline-passive exercise and ΔHRpassive-active, between the two groups, suggests that both mechanoreceptors and central neural command played limited roles in increased BP and HR drive during low-intensity dynamic exercise tests.
Regorafenib, Ipilimumab, and Nivolumab for Patients With Microsatellite Stable Colorectal Cancer and Disease Progression With Prior Chemotherapy
Authors: Fakih Marwan , Sandhu Jaideep , Lim Dean , Li Xiaochen , Li Sierra , Wang Chongkai 
Published: March 2023

ImportanceImmunotherapy combinations with activity in patients with microsatellite stable (MSS) metastatic colorectal cancer need to be identified.ObjectiveTo determine the recommended phase 2 dose (RP2D) of regorafenib, ipilimumab, and nivolumab (RIN) and evaluate its activity in an expansion cohort of patients with MSS metastatic colorectal cancer.Design, Setting, and ParticipantsThis nonrandomized clinical trial was a single-center 3 + 3 dose de-escalation study with an effectiveness expansion cohort at the RP2D. After the identification of the RP2D, a study amendment was executed to explore a regorafenib dose optimization strategy to mitigate skin-related toxic effects. Study enrollment occurred between May 12, 2020, and January 21, 2022. The trial was conducted at a single academic center. A total of 39 patients with MSS metastatic colorectal cancer whose disease progressed after standard chemotherapy and who had not received prior regorafenib or anti–programmed cell death protein 1 therapy were included.InterventionsPatients received regorafenib daily for 21 days every 4 weeks; fixed-dose ipilimumab, 1 mg/kg, intravenously every 6 weeks; and fixed-dose nivolumab, 240 mg intravenously every 2 weeks. Patients were treated until progression, unacceptable toxic effects, or completion of 2 years of therapy.Main Outcomes and MeasuresThe primary end point was RP2D selection. Secondary end points were safety and overall response rate (ORR) according to the Response Evaluation Criteria in Solid Tumours at the RP2D level.ResultsA total of 39 patients were enrolled, 23 (59.0%) were female, median age was 54 years (range, 25-75 years), 3 were Black (7.7%), and 26 were White (66.7%). No dose-limiting toxic effects were noted in the first 9 patients at the starting dose of RIN, with regorafenib dosed at 80 mg daily. No dose de-escalation was needed. This dose was declared the RP2D. Twenty more patients were enrolled at this level. The ORR, median progression-free survival (PFS), and overall survival (OS) in the RP2D cohort were 27.6%, 4 months (IQR, 2-9 months), and 20 months (IQR, 7 months to not estimable), respectively. For the 22 patients without liver metastases, the ORR, PFS, and OS were 36.4%, 5 months (IQR, 2-11), and greater than 22 months, respectively. A dose optimization cohort with regorafenib at 40 mg/d on cycle 1 and 80 mg/d on cycle 2 and beyond was associated with lower skin and immune toxic effects but had limited activity with stable disease for 5 of 10 patients as the best response.Conclusions and RelevanceResults of this nonrandomized clinical trial suggest that RIN at the RP2D demonstrated interesting clinical activity in patients with advanced MSS colorectal cancer without liver metastases. These findings should be confirmed in randomized clinical trials.Trial RegistrationClinicalTrials.gov Identifier: NCT04362839