bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in collaboration structures and impact among prominent researchers in Europe and North America
Authors: Danús Lluís , Muntaner Carles , Krauss Alexander , Sales-Pardo Marta , Guimerà Roger 
Published: April 2023

AbstractScientists collaborate through intricate networks, which impact the quality and scope of their research. At the same time, funding and institutional arrangements, as well as scientific and political cultures, affect the structure of collaboration networks. Since such arrangements and cultures differ across regions in the world in systematic ways, we surmise that collaboration networks and impact should also differ systematically across regions. To test this, we compare the structure of collaboration networks among prominent researchers in North America and Europe. We find that prominent researchers in Europe establish denser collaboration networks, whereas those in North America establish more decentralized networks. We also find that the impact of the publications of prominent researchers in North America is significantly higher than for those in Europe, both when they collaborate with other prominent researchers and when they do not. Although Europeans collaborate with other prominent researchers more often, which increases their impact, we also find that repeated collaboration among prominent researchers decreases the synergistic effect of collaborating.
Boundedness and large time behavior of solutions of a higher-dimensional haptotactic system modeling oncolytic virotherapy
Authors: Zheng Jiashan , Ke Yuanyuan 
Published: April 2023

This paper is concerned with the higher-dimensional haptotactic system modeling oncolytic virotherapy, which was initially proposed by Alzahrani–Eftimie–Trucu [Multiscale modelling of cancer response to oncolytic viral therapy, Math. Biosci. 310 (2019) 76–95] (see also the survey Bellomo–Outada et al. [Chemotaxis and cross-diffusion models in complex environments: Models and analytic problems toward a multiscale vision, Math. Models Methods Appl. Sci. 32 (2022) 713–792]) to model the process of oncolytic viral therapy. We consider this problem in a bounded domain [Formula: see text] with zero-flux boundary conditions. Although the [Formula: see text]-norm of the extracellular matrix density [Formula: see text] is easily obtainable, the remodeling process still causes difficulty due to the deficiency of regularity for [Formula: see text]. Relying on some [Formula: see text]-estimate techniques, in this paper, under the mild condition on parameters, we finally established the existence of global-in-time classical solution, which is bounded uniformly. Moreover, the large time behavior of solutions to the problem is also investigated. Specially speaking, when [Formula: see text], the corresponding solution of the system decays to [Formula: see text] algebraically. To the best of our knowledge, these are the first results on boundedness and asymptotic behavior of the system in three-dimensional space.
Evaluating the Implementation of Patient-Reported Outcomes in Heart Failure Clinic: A Qualitative Assessment
Authors: Brown-Johnson Cati , Calma Jamie , Amano Alexis , Winget Marcy , Harris Sonia R. , Vilendrer Stacie , Asch Steve M. , Heidenreich Paul , Sandhu Alexander T. , Kalwani Neil M. 
Published: April 2023

Background:
Patient-reported outcomes (PROs) may improve care for patients with heart failure. The Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) is a patient survey that captures symptom frequency, symptom burden, physical limitations, social limitations, and quality of life. Despite the utility of PROs and the KCCQ-12, the implementation and routine use of these measures can be difficult. We conducted an evaluation of clinician perceptions of the KCCQ-12 to identify barriers and facilitators to implementation into clinical practice.

Methods:
We conducted interviews with cardiologists from 4 institutions across the United States and Canada (n=16) and observed clinic visits at 1 institution in Northern California (n=5). Qualitative analysis was conducted in 2 rounds: (1) rapid analysis constructed around major themes related to the aims of the study and (2) content analysis with codes derived from the rapid analysis and implementation science.

Results:
Most heart failure physicians and advanced practice clinicians reported that the KCCQ-12 was acceptable, appropriate, and useful in clinical care. Clinician engagement efforts, trialability, and the straightforward design of the KCCQ-12 facilitated its use in clinical care. Further opportunities identified to facilitate implementation include more streamlined integration into the electronic health record and comprehensive staff education on PROs. Participants highlighted that the KCCQ-12 was useful in clinic visits to improve the consistency of patient history taking, focus patient-clinician conversations, collect a more accurate account of patient quality of life, track trends in patient well-being over time, and refine clinical decision-making.

Conclusions:
In this qualitative study, clinicians reported that the KCCQ-12 enhanced several aspects of heart failure patient care. Use of the KCCQ-12 was facilitated by a robust clinician engagement campaign and the design of the KCCQ-12 itself. Future implementation of PROs in heart failure clinic should focus on streamlining electronic health record integration and providing additional staff education on the value of PROs.

Registration:

URL:
https://clinicaltrials.gov
; Unique identifier: NCT04164004.
Endovascular Thrombectomy Versus Best Medical Management Beyond 24 Hours From Last Known Well in Acute Ischemic Stroke Due to Large Vessel Occlusion
Authors: Dhillon Permesh Singh , Butt Waleed , Jovin Tudor G. , Podlasek Anna , McConachie Norman , Lenthall Robert , Nair Sujit , Malik Luqman , Krishnan Kailash , Dineen Robert A. , England Timothy J. 
Published: April 2023

Background
The safety and efficacy of endovascular thrombectomy (EVT) in patients with acute ischemic stroke due to large vessel occlusion presenting beyond 24 hours from last known well (LKW) remains undetermined.

Methods
In this single center study, we identified patients with large vessel occlusion who were eligible for EVT based on noncontrast computed tomography (CT)/CT angiography (without CT perfusion or magnetic resonance imaging) using an Alberta Stroke Program Early CT Score of ≥5, National Institutes of Health Stroke Scale of ≥6, and presenting beyond 24 hours from LKW, between January 2018 and March 2022. During the study period, EVT service limitations meant patients eligible for EVT presenting outside service hours, routinely received best medical management (BMM). Functional and safety outcomes were compared between patients receiving EVT or BMM following multivariable adjustment for age, baseline stroke severity, Alberta Stroke Program Early CT Score, time from LKW, IV thrombolysis, and clot location.

Results

Among 35 patients presenting beyond 24 hours from LKW and eligible for EVT, 19 (54%) were treated with EVT and 16 (46%) with BMM. Alberta Stroke Program Early CT Score were similar across both groups (EVT: 7 [6.75–8] versus BMM: 7 [6–8]), but not the baseline National Institutes of Health Stroke Scale (EVT: 17 [11–19.5] versus BMM: 20 [9.75–26]). No significant difference was observed between the EVT and BMM groups in the symptomatic intracranial hemorrhage (5.3% versus 0%;
P
=0.28) or mortality (26.3% versus 37.5%;
P
=0.42) rates, respectively. The modified Rankin scale at 90 days (adjusted common odds ratio [OR], 1.94; [95% CI 0.42–8.87];
P
=0.39) and functional independence rate, although numerically higher in the EVT group compared with the BMM group (modified Rankin scale≤2; 36.9% versus 18.8%; adjusted OR, 4.34; [95% CI 0.34–54.83];
P
=0.25), were not significantly different. 94.7% of patients treated with EVT achieved successful reperfusion (modified thrombolysis in cerebral infarction 2b–3).

Conclusion
In routine clinical practice, EVT beyond 24 hours from LKW appears safe and feasible, when performed in patients with acute ischemic stroke who were deemed eligible for EVT by noncontrast CT /CT angiography alone. A large collaborative randomized trial assessing the efficacy of EVT beyond 24 hours is warranted. Our findings provide a basis for the sample size estimate for an adequately powered trial.
Interrogating Two Concepts in Islamic Criminal Jurisprudence: Victim’s Family vs. Offender’s Family
Authors: Mohamed Gaber 
Published: April 2023

Abstract
Calls for abolition of the death penalty invariably encounter a negative response by those political regimes which exploit the classical rigid definition of victim’s family concept. The death penalty could not be abolished by the legislative authority because the heirs of victim are the only people who have the right to waive death penalty based on the classical understanding of the definition of the victim’s family. I argue that if the definition of the victim’s family is revisited to have the same flexibility as the offender’s family, the Nation-State may be included in the definition, and the legislative authority will have the power to abolish the death penalty. Furthermore, revisiting these two terms within the contemporary context would have an impact on the gap between Shariʿa and national legal systems. The social contexts of the two legal systems have been shaped based on two different social bases: modernity and pre-modernity. The two different social bases have created a gap that is exploited in many controversial issues, not only the death penalty in the Muslim world but also harsh penalties in some Muslim legal systems, the right of a husband to discipline his wife, gender equality, legal perspectives on homosexuality, the absence of a clear distinction between public and private realms, and ignoring any distinction separating out the role to the public and nation in crimes of homicide and bodily injuries. Thus, the purpose of reviewing these two concepts from a perspective oriented towards the contemporary context is an attempt to bridge the gap between national criminal legal systems and the Shariʿa pre-modern criminal system, so that these controversial issues may be appropriately relocated in the modern national systems of Egypt and the Muslim world.
National Analysis of Motor Vehicle Collision-Associated Mortality Among Opioid Users From 2010 to 2020: The Need for Effective Prevention Policies
Authors: Watts Emelia , Patel Heli , Abella Maveric , Kim Jason , Elkbuli Adel 
Published: April 2023

The purpose of this study is to evaluate the trends in the incidence of opioid-associated motor vehicle fatalities in the United States (US) over the past decade and identify geographic or demographic trends. We conducted a retrospective repeated cross-sectional study utilizing the CDC WONDER Multiple Cause of Death Database to gather data on opioid-associated motor vehicle fatalities from 2010 to 2020. The southern US experienced the highest percent increase in opioid-related fatalities from 2010 to 2020 (263.1%), followed by the Midwest (160.7%), the west (86.3%), and the northeast (10.0%). The use of opioids increases a driver’s risk of motor vehicle crash involvement, especially amongst non-Hispanic White males between 25 and 55 years of age who live in the southern states of the US. There is a need for augmented opioid-related policy concerning the potency and intake of prescription opioids to reduce motor vehicle fatalities.
Assessment of Work Loss Due to COVID-19 Lockdown and its Economic Consequences on Families in Urban Kakinada—A Cross-sectional Study
Authors: Poorna P. Sai , Babu G. Krishna , Priyanka M. Vineela 
Published: April 2023

In India due to the COVID-19 lockdown 122 million people lost their jobs in April. It caused many effects like increased starvation, job loss, poverty, alcoholism and gender violence. This study was undertaken to assess the work loss due to the COVID-19 lockdown and its economic consequences on families in urban Kakinada. A community-based cross-sectional study was conducted during 15 April–15 May in 40th urban ward of Kakinada. The sample size was calculated by taking 10% of the ward population. By the systematic random sampling method, 300 samples were collected. Institutional Ethics Committee approval was obtained before data collection. Data were collected by semi-structured questionnaire and entered in MS Excel 2010 and it was analysed using SPSS 21. Descriptive statistics p value of <.05 was taken as statistically significant. The prevalence of work loss was found to be 42%. Work loss has significantly caused a decrease in the purchase of protective foods like vegetables (10.3%), fruits (22.4%), milk (16.1%), non-veg (36.2%) and groceries (35.1%). About 44.6% have chronic diseases and 34.7% among work loss borrowed money for medical expenditure. It affected the health of families in terms of decreased purchase of protective foods resulting in food insecurity, and increased burden on medical expenditure due to chronic diseases. JEL Code: D1
Recanalization of external iliac artery occlusion in a patient with spinal stenosis using medications: a case report
Authors: Cho Wan-Jae , Chi Hee-Man , Ryu Ji-Hyun , Lee Jun-Seok 
Published: April 2023

Background Iliac artery occlusion accompanied by spinal canal stenosis is rare. All reported cases were treated with endovascular stenting for iliac artery occlusion. We report the first case of external iliac artery occlusion accompanied by spinal stenosis, which was successfully treated with conservative treatment. Case presentation A 66-year-old man with lower extremity pain and claudication visited the outpatient spine clinic. He complained of a tingling sensation in the L5 dermatome of the right leg and L4 dermatome of the left leg. Magnetic resonance imaging showed central stenosis in at the L4–5 and L5–S1 levels, and lateral recess stenosis at the L5–S1 level. The patient's symptoms were ambiguous with mixed neurological claudication and vascular claudication. Computed tomography of the lower extremity artery showed complete occlusion in the right external iliac artery. Conservative treatment with clopidogrel and beraprost sodium was performed. After treatment, his symptoms gradually improved. Clopidogrel and beraprost sodium were continued for 4 years. Follow-up computed tomography at 4 years showed recanalization of the right external iliac artery occlusion. Conclusions We describe a rare case of external iliac artery occlusion and spinal stenosis. External iliac artery occlusion may be successfully treated only with conservative treatment using medication.
Effects on blood parameters from hand-arm vibrations exposure
Authors: Johansson Niclas , Ragnebro Oscar , Stjernbrandt Albin , Graff Pål , Bryngelsson Ing-Liss , Vihlborg Per 
Published: April 2023

Vibration exposure from handheld tools can affect the hands with neurological symptoms and vibration-induced Raynaud’s phenomenon (VRP). The underlying pathophysiological mechanisms are not fully known, however, changes in the composition of blood parameters may contribute to VRP with an increase in blood viscosity and inflammatory response. The aim of this study was to examine the effect on blood parameters in capillary blood from fingers that had been exposed to a vibrating hand-held tool. This study involved nine healthy participants who had been exposed to vibration and an unexposed control group of six participants. Capillary blood samples were collected before and after vibration exposure for the exposed group, and repeated samples also from the control group. The exposed groups were exposed to vibration for a 15-min period or until they reached a 5.0 m/s2 vibration dose. Analysis of blood status and differential counting of leucocytes was performed on the capillary blood samples. The results of the blood samples showed an increase in mean value for erythrocyte volume fraction (EVF), hemoglobin, red blood cell count, white blood cell count and neutrophils, as well as a decrease of mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration. The increase of EVF and neutrophils was statistically significant for samples taken from the index finger but not the little finger. Even though the study was small it showed that an acute vibration exposure to the hands might increase EVF and neutrophilic granulocytes levels in the capillary blood taken from index fingers.
Blade Plate With Autogenous Bone Grafting to Salvage Peri Ankle Nonunions
Authors: Emmelot Mees Paulus , Wagner Robert Kaspar , Janssen Stein Jasper , Kloen Peter 
Published: April 2023

Background: Salvage surgery for a nonunion around the ankle is challenging. Poor bone stock, stiffness, scarring, previous (or persistent) infection, and a compromised soft tissue envelope are common in these patients. We describe 15 cases that underwent blade plate fixation as salvage for a nonunion around the ankle, including patient/nonunion characteristics, Nonunion Scoring System (NUSS), surgical technique, healing rate, complications, and long-term follow-up with 2 patient-reported outcome measures. Methods: This is a retrospective case series from a level 1 trauma referral center. We included all patients that underwent blade plate fixation for a long-standing nonunion of the distal tibia, talus, or failed subtalar fusion. All patients had autogenous bone grafting, including 14 with posterior iliac crest grafts and 2 with femoral reamer irrigator aspirator grafting. Median follow-up was 24.4 months (interquartile range [IQR], 7.7-40). Main outcome measures were (time to) union, and functional outcomes using the 36-item Short Form Health Survey (SF-36) physical component summary (PCS) and mental component summary (MCS), and the Foot and Ankle Outcome Score (FAOS). Results: We included 15 adults with a median age of 58 years (IQR, 54-62). The median NUSS score at the time of index surgery was 46 (IQR, 34-54). Union was achieved after the index procedure in 11 of 15 patients. Additional surgery was performed in 4 of 15 patients. Union was achieved in all patients at a median of 4.2 months (IQR, 2.9-11). The median score for the PCS was 38 (IQR, 34-48, range 17-58, P = .009), for the MCS 52 (IQR, 45-60, range 33-62, P = .701), and for the FAOS 73 (IQR, 48-83). Conclusion: In this series, our use of blade plate fixation with autogenous grafting was an effective method for managing a nonunion around the ankle allowing for alignment correction, stable compression and fixation, union, and fair patient-reported outcome scores. Level of Evidence: Level IV, therapeutic.
New-onset persistent hyperglycemia with initiation of brentuximab treatment
Authors: Quintas Joseph , Mowatt Kelley B , Mullally Jamie A , Steinberg Amir 
Published: April 2023

Introduction The addition of brentuximab vedotin (BV) to adriamycin, vinblastine, and dacarbazine (AVD) has become the standard-of-care approach for advanced stage Hodgkin lymphoma (HL). This case describes a rare presentation of new-onset diabetes mellitus one month after initiation of BV + AVD therapy in a patient with HL. Case report A 41-year-old woman with pre-diabetes and obesity was started on BV + AVD for classical HL, nodular sclerosing type. Six weeks after initiating therapy, she was admitted for abdominal pain, at which time her blood glucose was noted to be 357 mg/dL. Her Hba1c was 8.1%. She required rapid acting insulin, and throughout admission, her glucose ranged from 132 to 263 mg/dL. After discharge, a fasting glucose of over 250 mg/dL deemed her ineligible to have a PET/CT performed to assess disease status. Management and outcome She was started on basal insulin, a DPP4-inhibitor, and a meglitinide analog. After initiation of therapy, her glucose levels were better controlled, and she was able to have her PET scan. Repeat Hba1c was 6.2% three months after initiation of glucose-lowering medications. She completed 6 cycles of BV + AVD therapy, with improving finger stick blood glucose (FSBG), and repeat Hba1c 1 month after completion of therapy was 5.2% on metformin monotherapy. Discussion Reports of brentuximab-induced hyperglycemia are rare in the literature, noted in just a few studies and one case report. Our case demonstrates a need to monitor blood glucose levels carefully during the initiation of BV therapy, especially in individuals with risk factors such as obesity, pre-diabetes mellitus, or diabetes mellitus.
Serum neurofilament light-chain levels and long-term treatment outcomes in relapsing-remitting multiple sclerosis patients: A post hoc analysis of the randomized CombiRx trial
Authors: Cutter Gary , Rudick Richard A , de Moor Carl , Singh Carol M , Fisher Elizabeth , Koster Thijs , Lublin Fred D , Wolinsky Jerry S , McFarland Henry , Jacobson Steven , Naylor Maria L 
Published: April 2023

Background CombiRx was a randomized, double-blind, placebo-controlled phase 3 trial in treatment-naive relapsing-remitting multiple sclerosis (RRMS) patients randomized to intramuscular interferon beta-1a (IM IFN beta-1a), glatiramer acetate (GA), or both therapies. Objective This analysis investigated changes in serum neurofilament light-chain (sNfL) levels in response to treatment and assessed baseline sNfL as a predictor of relapse. Methods RRMS patients treated with IM IFN beta-1a 30 µg weekly + placebo (n = 159), GA 20 mg/mL daily + placebo (n = 172), or IM IFN beta-1a + GA (n = 344) were included. A linear mixed model compared sNfL values over time. Cox regression models analyzed baseline sNfL and gadolinium-enhancing (Gd+) lesions as predictors of relapse. Results In all treatment arms, the proportion of patients with sNfL ≥16 pg/mL decreased significantly from baseline to 6 months and was maintained at 36 months. A significantly higher percentage of patients with both baseline sNfL ≥16 pg/mL and ≥1 Gd+ lesion experienced relapses within 90 days compared to patients with sNfL <16 pg/mL and/or no Gd+ lesions. Conclusion sNfL levels were reduced within 6 months and remained low at 36 months. Results suggest that the combination of lesion activity and sNfL was a stronger predictor of relapse than either factor alone.
A Real-time Look-ahead Trajectory Planning Methodology for Multi Small Line Segments Path
Authors: Zhang Sai , Liu Xinjun , Yan Bingkai , Bi Jie , Han Xiangdong 
Published: April 2023

AbstractWhen a robot is required to machine a complex curved workpiece with high precision and speed, the tool path is typically dispersed into a series of points and transmitted to the robot. The conventional trajectory planning method requires frequent starts and stops at each dispersed point to complete the task. This method not only reduces precision but also causes damage to the motors and robot. A real-time look-ahead algorithm is proposed in this paper to improve precision and minimize damage. The proposed algorithm includes a path-smoothing algorithm, a trajectory planning method, and a bidirectional scanning module. The path-smoothing method inserts a quintic Bezier curve between small adjacent line segments to achieve $$G^{2}$$

G
2

continuity at the junctions. The trajectory planning method utilizes a quartic polynomial and a double-quartic polynomial that can achieve a constant velocity at the velocity limitation. The bidirectional scanning module calculates the velocity at each trajectory planning segment point, simplifying calculation complexity and can be run in real time. The feasibility of the proposed algorithm is verified through simulations and experiments, which can be run in real time. In addition, high machining precision can be achieved by adjusting the relevant parameters.