bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of suicidal ideation among undergraduate students of Obafemi Awolowo University, Ile-Ife, Nigeria
Authors: Adebowale Olusegun F. , Omotehinse Oluwaseun Solomon 
Published: July 2023

PurposeThe main objective of this study is to determine the patterns of suicidal ideation among undergraduate students of Obafemi Awolowo University, Ile-Ife, Osun State.Design/methodology/approachThe study examined the pattern of suicidal ideation among undergraduate students of Obafemi Awolowo University, Ile-Ife, Nigeria. The study adopted a survey research design. The study population comprised all the 28,673 undergraduate students of the university out of which 800 students were selected by stratified random sampling for the study. A questionnaire was used in gathering data for this study. Data collected were analysed using descriptive statistics, cluster and factor analyses. The study concluded that the patterns of suicide ideation among undergraduate students of Obafemi Awolowo University are passive. It is recommended that Obafemi Awolowo University students adopt the physical and online counselling services provided by the institution to aid their mental and psychological well-being.FindingsFindings revealed that the prevalence of suicidal ideation among the students was low (89.9%). Result also showed that pattern of suicidal ideation was passive (85.2%). In addition, result showed that social isolation (31.3%), hopelessness (29.4%), disappointment with school result (26.5%) and unmet expectation (12.9%) were possible factors of suicidal ideation among undergraduate students of Obafemi Awolowo University, Ile-Ife, Nigeria.Research limitations/implicationsThis study only established the patterns of suicidal ideation among students of Obafemi Awolowo University Ile-Ife, without any reference to treatment of students with suicidal ideation. Since the patterns of suicidal ideation had been established, it is suggested that further research be conducted on the treatment and prevention of suicide among the students.Originality/valueThe research was conducted by the researchers, and data were adequately collected and prepared following research ethics and guidelines. Results were presented as revealed by the analysis of the data.
Early laparoscopic cholecystectomy for acute cholecystitis: Does age matter?
Authors: Barka Malek , Jarrar Mohamed Salah , Ben Abdessalem Zied , Hamila Fehmi , Youssef Sabri 
Published: July 2023

AimAdvances in laparoscopic surgery and perioperative care have improved the prognosis of operated patients, especially the oldest among them. This study aimed to assess the outcomes of early laparoscopic cholecystectomy for acute calculous cholecystitis in older adult patients.MethodsA retrospective analysis was carried out of 567 patients who underwent early laparoscopic cholecystectomy for acute calculous cholecystitis between January 2003 and July 2021. The outcomes of older adult patients (≥ 75 years) were compared with those of younger patients.ResultsThe older adult group had significantly more patients with an American Society of Anesthesiologists score ≥3 (37.5% vs 8.3%; P < 0.001) and more severe acute calculous cholecystitis (grade II; 82.8% vs 67%; P = 0.01). There were no significant differences regarding operative time (90 vs 80 min; P = 0.064), conversion rate (20.3% vs 13.5%; P = 0.144), and both intra‐ and postoperative morbidity, principally bile duct injuries (1.6% vs 0%; P = 0.113) and bile leakage (0% vs 1.2%; P = 1).ConclusionEarly laparoscopic cholecystectomy could be proposed safely for older adult patients with mild and moderate acute cholecystitis. Geriatr Gerontol Int 2023; 23: 671–675.
Oral antimicrobial therapy for cellulitis versus outpatient parenteral antimicrobial therapy: a single‐centre audit of cellulitis outcomes
Authors: Bowhay Thomas R. , Tsang Tiffany , Wei Jeremy C. Z. , Edwik Wafa , Fridman Avi , Hubber Julia , Jo Jae Y. , Mckay Nicole , O'Brien Catherine , Osmond‐Wallam Joe , Smythe James , Crump John A. , Arnold Brendan 
Published: July 2023

AbstractBackgroundCellulitis is a common acute skin and soft tissue infection that causes substantial morbidity and healthcare costs.AimsTo audit the impact on cellulitis management, regimen tolerability and outcomes of switching from outpatient parenteral antimicrobial therapy (OPAT) using intravenous (i.v.) cefazolin once daily plus probenecid to oral beta‐lactam therapy (OBLT) using oral flucloxacillin plus probenecid.MethodsWe undertook a retrospective audit on cellulitis management, regimen tolerability and outcomes at the Dunedin Public Hospital Emergency Department (ED) before and after a change of the local outpatient cellulitis treatment pathway from OPAT using i.v. cefazolin once daily plus probenecid to OBLT using oral flucloxacillin plus probenecid.ResultsOPAT was used in 97/123 (78.9%) patients with cellulitis before compared to 1/70 (1.4%) after the pathway change (odds ratio (OR), 0.04, P < 0.01). OBLT was used in 26/123 (21.1%) patients with cellulitis before and 69/70 (98.6%) after (OR, 218.8, P < 0.01). Antimicrobial change due to intolerance occurred in 4/123 (3.2%) patients with cellulitis before and 4/70 (5.7%) after (OR, 1.8, P, not significant (NS)) the pathway change. Inpatient admission within 28 days occurred in 15/123 (12.2%) cellulitis patients before and 9/70 (12.9%) after (OR, 1.1, P, NS) the pathway change.ConclusionsImplementation of a change in outpatient cellulitis treatment pathway resulted in a significant change in prescribing practice. Our findings suggest that OBLT was both tolerable and had similar outcomes to OPAT.
The role of haptoglobin in the diagnosis of preeclampsia and HELLP syndrome and in predicting neonatal outcomes
Authors: Ünal Hamza Bilal , Dal Yusuf , Karagün Şebnem , Coşkun Ayhan 
Published: July 2023

AbstractObjectiveThe study aimed to determine whether maternal serum haptoglobin values could have an effect on predicting diagnosis and neonatal outcomes in preeclampsia and HELLP syndrome.Materials and MethodsHundred sixteen pregnant women who met the inclusion criteria were included in the study. To evaluate whether serum haptoglobin level in maternal blood could be used in early diagnosis of preeclampsia and HELLP syndrome, 49 pregnant women diagnosed with preeclampsia and 13 pregnant women diagnosed with HELLP syndrome were included in the study group, and 54 healthy pregnant women in the control group. The groups were compared regarding maternal serum haptoglobin level, platelet count, ALT, AST, LDH, and uric acid levels. Moreover, the age, obstetric histories, and newborn outcomes of all pregnant women were recorded and compared between groups.ResultsThe mean haptoglobin values were 0.29 ± 0.23 g/L in the HELLP syndrome group, 1.01 ± 0.52 g/L in the preeclampsia group, and 1.16 ± 0.37 g/L in the control group. The mean haptoglobin result was lower in the HELLP syndrome group compared to the preeclampsia and control groups (p < 0.001). While the differences between HELLP syndrome and the control and preeclampsia groups were statistically significant, no significant difference was determined between the preeclampsia and control groups. There was a significant positive correlation between haptoglobin value with the week of delivery, umbilical cord pH value, and the first and fifth‐minute Apgar scores (p < 0.05).ConclusionIt was concluded that haptoglobin values could be used together with other biochemical parameters to diagnose HELLP syndrome and predict newborn outcomes.
Suspected cancer (red flag) referrals: A review of our experience in Northern Ireland
Authors: Causey Christine , Marley John 
Published: July 2023

AbstractAimHead and neck cancer continues to represent a significant source of morbidity and mortality for patients. Alongside prevention, early recognition is key to improving patient outcomes. We aim to present our experience of suspected cancer referrals to the oral surgery/oral medicine units within a dental hospital in Northern Ireland in terms of patient demographic, referral quality, and referral outcome.Materials and MethodsPatients who were referred to the oral surgery or oral medicine departments within the Queen's University Belfast Dental hospital between January and September 2018, and placed on the suspected cancer (Red Flag) pathway, had their records reviewed. Data was extracted by 2 calibrated dentists using predetermined data extraction forms.ResultsOverall, 377 patient referrals were identified with the majority coming from dentists (GDPs) and general practitioners (GMPs). GMP referrals were commonly via the e‐referral system (97%), and GDP via post or email (97%). E‐referrals underwent triage faster than other referral methods. Of the original referrals, 62% remained on the red flag pathway following consultant triage, and all were allocated appointments within 2 weeks. Ulcers, swellings, and white patches were the most referred lesions with just 5.5% of referrals including clinical photographs. Overall, positive predictive value (PPV) was 5.3% (8% for GDPs and 3% for GMPs).ConclusionOur department successfully met the 2‐week target in all cases. PPV does however remain low, but within recognised guidance limits, and could potentially be improved by further education of referrers and/or inclusion of a clinical photo at the time of referral.
Transvenous lead extraction of implantable cardioverter‐defibrillators: A comprehensive outcome‐and risk factor analysis
Authors: Chung Da‐Un , Burger Heiko , Kaiser Lukas , Osswald Brigitte , Bärsch Volker , Nägele Herbert , Knaut Michael , Reichenspurner Hermann , Gessler Nele , Willems Stephan , Butter Christian , Pecha Simon , Hakmi Samer ,   the GALLERY investigators
Published: July 2023

AbstractBackgroundDevice complications, such as infection or lead dysfunction necessitating transvenous lead extraction (TLE) are continuously rising amongst patients with transvenous implantable‐cardioverter‐defibrillator (ICD).ObjectivesAim of this study was to characterize the procedural outcome and risk‐factors of patients with indwelling 1‐ and 2‐chamber ICD undergoing TLE.MethodsWe conducted a subgroup analysis of all ICD patients in the GALLERY (GermAn Laser Lead Extraction RegistrY) database. Predictors for procedural failure and all‐cause mortality were assessed.ResultsWe identified 842 patients with an ICD undergoing TLE with the mean age of 62.8 ± 13.8 years. A total number of 1610 leads were treated with lead dysfunction (48.5%) as leading indication for extraction, followed by device‐related infection (45.4%). Lead‐per‐patient ratio was 1.91 ± 0.88 and 60.0% of patients had dual‐coil defibrillator leads. Additional extraction tools, such as mechanical rotating dilator sheaths and snares were utilized in 6.5% of cases. Overall procedural complications occurred in 4.3% with 2.0% major complications and a procedure‐related mortality of 0.8%. Clinical success rate was 97.9%. All‐cause in‐hospital mortality was 3.4%, with sepsis being the leading cause for mortality. Multivariate analysis revealed lead‐age ≥10 years (OR:5.82, 95%CI:2.1‐16.6; p = .001) as independent predictor for procedural failure. Systemic infection (OR:9.57, 95%CI:2.2‐42.4; p < .001) and procedural complications (OR:8.0, 95%CI:2.8‐23.3; p < .001) were identified as risk factors for all‐cause mortality.ConclusionsTLE is safe and efficacious in patients with 1‐ and 2‐chamber ICD. Although lead dysfunction is the leading indication for extraction, systemic device‐related infection is the main driver of all‐cause mortality for ICD patients undergoing TLE.
U–Pb ID-TIMS Age of Rutile from the North Muya Block Eclogites (Northeastern Transbaikal Area) as a Tracer of the Duration for Exhumation of the Continental Lithosphere
Authors: Skuzovatov S. Yu. , Rizvanova N. G. , Skublov S. G. , Shatsky V. S. 
Published: July 2023

Abstract
Rutile, an abundant mineral phase of high-grade rocks, is used as a tracer of lithospheric evolution for deep zones of orogenic belts. This study presents new ID-TIMS U–Pb geochronological, mineralogical, and geochemical data for rutile from eclogites of the North Muya block (Baikal–Muya fold belt) in order to examine the applicability of its age estimates relative to the exhumation process of high-grade rocks. The assemblage of mineral inclusions in rutile (mainly titanite, epidote, and amphibole) indicate rutile growth through titanite breakdown reactions during prograde metamorphism epidote–amphibolite or amphibolite–facies rocks. The range of Zr contents and estimated Zr-in-rutile crystallization temperatures correspond to conditions from prograde (619–638°С at 1.5 GPa) up to peak ones (659–684°С for 2.5 GPa). The U–Pb age estimate (605 Ma) is notably younger than that of peak eclogitic metamorphism (630 Ma) and highlight the protracted cooling history of the eclogite-bearing complex during its evolution below the closure temperature of the U–Pb isotope system in rutile (~500–525°С) during tectonic denudation or erosion of continental complexes.
Leisure sedentary behaviour increases the risk of venous thromboembolism: a Mendelian randomisation study
Authors: Chen Liang , You Guochang , Yang Zhenmei , Shen Runnan , Zhang Rong , Zhu Dongxi , Wang Linlu , Lin Shen , Lv Lin , Huang Kai 
Published: July 2023

Abstract
Background
Venous thromboembolism (VTE) is a substantial contributor to the global burden of disease. Observational studies have suggested that leisure sedentary behaviours (LSB) are related to the risk of VTE; however, the causal role of LSB in VTE remains unclear.

Methods
Using data obtained from genome-wide association studies in the UK Biobank (N = 422,218), we identified 84, 21, and 4 single nucleotide polymorphisms (SNPs) related to sedentary television (TV) watching, computer use, and driving, respectively. These SNPs were employed as instrumental variables. Summary statistics for SNP-VTE associations was obtained from the FinnGen study (5,403 cases and 130,235 controls). Two-sample Mendelian randomisation (MR) analyses were performed using inverse-variance weighted (IVW), MR-Egger,weighted median, and weighted mode approaches. Sensitivity analyses were conducted to ensure robustness of the results.

Results
The main IVW approach demonstrated a positive association between the genetically predicted sedentary TV watching and the risk of VTE [odds ratio (OR):1.35, 95% confidence interval (CI):1.02—1.80, P = 0.039]. However, no significant association was observed for genetically predicted sedentary computer use or driving and VTE risk. The results from our series of sensitivity analyses, including Cochran’s Q test, MR-Egger intercept test, and MR-Pleiotropy RESidual Sum and Outlier method, further supported these findings.

Conclusion
This study provides evidence of an association between genetically predicted sedentary TV watching and the risk of VTE. Further studies are required to elucidate the underlying causal mechanisms.
The strategy of laparoscopic surgery for asymptomatic antenatally diagnosed choledochal cyst
Authors: Zhang Xuepeng , Jin Jianli , Qiu Tong , Zhou Jiangyuan , Che Guowei , Ji Yi , Xu Zhicheng 
Published: July 2023

Abstract
Background
The aim was to investigate the characteristics, surgical management, and outcomes of asymptomatic patients with antenatally diagnosed choledochal cysts (ADCCs) and to justify the strategy of laparoscopic surgery (LS) for them in our hospital.

Methods
We developed our LS strategy for asymptomatic ADCCs. Patients with asymptomatic ADCCs who underwent LS or open surgery (OS) during January 2010 and January 2020 were included. Patients with recorded symptomatic ADCCs were exclude. All data of group LS and group OS were statistically compared and analyzed.

Results
Twenty-five patients received LS and 18 patients received OS were included. There was no significant difference in baseline characteristics between the groups. A total of 65.1% of biliary sludge formation was detected preoperatively by ultrasonography (US) (72.0% in group LS, 55.6% in group OS, P = 0.26). Compared to the OS group, the LS group had a longer operative time (313.4 ± 27.2 vs. 154.0 ± 11.9 min, P = 0.02), shorter postoperative fasting period (3.1 ± 1.2 vs. 6.2 ± 2.3 days, P = 0.03), and shorter postoperative hospital stay (5.1 ± 1.9 vs. 9.2 ± 1.1 days, P = 0.03). The incidence of late complications, such as reflux cholangitis, adhesive intestinal obstruction, and biliary enteric anastomotic stricture with stone formation, was not significantly different between the two groups. The liver function and liver stiffness of all patients in the two groups were normal.

Conclusions
Based on the strategy for asymptomatic ADCCs in our hospital, the perioperative safety and midterm follow-up results after LS were satisfactory and comparable to those after OS.
Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents
Authors: Ismail Rania S. M. , El Kerdawy Ahmed M. , Soliman Dalia H. , Georgey Hanan H. , Abdel Gawad Nagwa M. , Angeli Andrea , Supuran Claudiu T. 
Published: July 2023

AbstractAn optimization strategy was adopted for designing and synthesizing new series of 2-oxindole conjugates. Selected compounds were evaluated for their antiproliferative effect in vitro against NCI-60 cell lines panel, inhibitory effect on carbonic anhydrase (CA) isoforms (hCAI, II, IX and XII), and protein kinases. Compounds 5 and 7 showed promising inhibitory effects on hCA XII, whereas compound 4d was the most potent inhibitor with low nanomolar CA inhibition against all tested isoforms. These results were rationalized by using molecular docking. Despite its lack of CA inhibitory activity, compound 15c was the most active antiproliferative candidate against most of the 60 cell lines with mean growth inhibition 61.83% and with IC50 values of 4.39, 1.06, and 0.34 nM against MCT-7, DU 145, and HCT-116 cell lines, respectively. To uncover the mechanism of action behind its antiproliferative activity, compound 15c was assessed against a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDFGR and BRAF) showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively. These results were also explained through molecular docking.
Green NiFe2O4 nano-sorbent construction via Foeniculum vulgare extract for efficient barium ions removal
Authors: Elamin Nuha Y. , El-Fattah Wesam Abd , Modwi Abueliz 
Published: July 2023

Abstract
Ba ions were successfully adsorbed using green NiFe2O4-NPs that were generated using Foeniculum vulgare seeds extract. To investigate the structural and textural characteristics of the adsorbent powder, X-ray diffraction (XRD), nitrogen adsorption–desorption isotherm, X-ray photoelectron spectroscopy (XPS), Fourier transformer infrared (FTIR), and scanning/transmission electron microscopy (SEM) examinations were conducted. The FTIR and EDX investigations revealed the formation of NiFe2O4-NPs as indicated by the elemental composition and the bonding patterns. Some remarkable properties, including the growth of crystallite size and lattice parameters, were reached due to the extract addition, as revealed further by XRD examination. The sorption results were consistent with the Langmuir isotherm model, and the kinetic data were in accordance with pseudo-second-order kinetics. As a result of the electrostatic interaction between the negatively charged NiFe2O4-NPs surface and the positively charged Ba (II) ions, the adsorption process improved significantly above pHzc. The NiFe2O4 nanostructures with high competence for Ba2+ adsorption could be nominated to abolish additional harmful metal cations.
Demarcation of Intensity From 3 to 5 Zones Aids in Understanding Physiological Performance Progression in Highly Trained Under-23 Rowing Athletes
Authors: Watts Sophie P. , Binnie Martyn J. , Goods Paul S.R. , Hewlett Jamie , Fahey-Gilmour Jack , Peeling Peter 
Published: July 2023

Abstract
Watts, SP, Binnie, MJ, Goods, PSR, Hewlett, J, Fahey-Gilmour, J, and Peeling, P. Demarcation of intensity from 3 to 5 zones aids in understanding physiological performance progression in highly trained under-23 rowing athletes. J Strength Cond Res XX(X): 000–000, 2023—The purpose of this investigation was to compare 2 training intensity distribution models (3 and 5 zone) in 15 highly trained rowing athletes (n = 8 male; n = 7 female; 19.4 ± 1.1 years) to determine the impact on primary (2,000-m single-scull race) and secondary (2,000-m ergometer time trial, peak oxygen consumption [V̇O2peak], lactate threshold 2 [LT2 power]) performance variables. Performance was assessed before and after 4 months training, which was monitored through a smart watch (Garmin Ltd, Olathe, KS) and chest-strap heart rate (HR) monitor (Wahoo Fitness, Atlanta, GA). Two training intensity distribution models were quantified and compared: a 3-zone model (Z1: between 50% V̇O2peak and lactate threshold 1 (LT1); Z2: between LT1 and 95% LT2; Z3: >95% LT2) and a 5-zone model (T1–T5), where Z1 and Z3 were split into 2 additional zones. There was significant improvement in LT2 power for both male (4.08% ± 1.83, p < 0.01) and female (3.52% ± 3.38, p = 0.02) athletes, with male athletes also demonstrating significant improvement in 2,000-m ergometer time trial (2.3% ± 1.92, p = 0.01). Changes in V̇O2peak significantly correlated with high-quality aerobic training (percent time in T2 zone; r = 0.602, p = 0.02), whereas changes in LT2 power significantly correlated with “threshold” training (percent time in T4 zone; r = 0.529, p = 0.04). These correlations were not evident when examining intensity distribution through the 3-zone model. Accordingly, a 5-zone intensity model may aid in understanding the progression of secondary performance metrics in rowing athletes; however, primary (on-water) performance remains complex to quantify.
La biopolítica y el discurso de la regla
Authors: Gómez-Pineda Floro Hermes , Martínez-Vargas John Fitzgerald 
Published: July 2023

El siglo XXI se está consolidando como la era en que la imposición y el uso del discurso de la biopolítica se han perfeccionado. Con su desarrollo agigantado, surgen profundas transformaciones socioculturales y, por ende, la necesidad de recomprender las relaciones entre las áreas del conocimiento que, por algunos autores, se consideraban separadas y distanciadas en su análisis, tales como la ética, la política y el derecho. Debido a que el discurso de la regla mutó al aparecer la biopolítica, Foucault explica que la regla jurídica derivada de la soberanía transita hacia la regla naturalizada, es decir, a la norma que responde a una sutil colonización de lo jurídico por parte del saber médico. Esta transición solo es posible comprenderla si se entiende qué es el liberalismo y qué es,
entendido como práctica y como racionalización de la gestión del gobierno en cuanto la armonización entre el desorden, la policía y la libertad.