bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Influencing Postoperative Recovery Time of Patients With Gastric Cancer
Authors: Shao Jun , Xie Jiang , Sun Peng , Zhang Yunpeng , Chen Daqing , Chen Ying , Xu Ming 
Published: May 2023

Background:
To explore the factors associated with prolonged enhanced recovery after surgery (ERAS) time in gastric cancer patients who underwent gastrectomy.

Methods:
This was a retrospective of patients with gastric cancer who received ERAS at our hospital between 01/2014 and 01/2022. The outcome was prolonged ERAS time. Factors associated with prolonged ERAS time of patients undergoing gastric cancer surgery were analyzed by logistic regression.

Results:
Among 663 patients, 182 (27.6%) patients had a prolonged ERAS time. The postoperative time to the first flatus time was 2.8 ± 1.2 days. There were 41 (6.2%) patients with intestinal obstruction, 25 (3.8%) with abdominal infection, and four (0.5%) with anastomotic leakage. The multivariable analysis showed that age >80 years (OR = 1.57, 95% CI: 1.31–4.40, P = 0.048), laparoscopic surgery (OR = 0.45, 95% CI: 0.21–0.95, P = 0.035), intraoperative jejunostomy (OR = 334.60, 95% CI: 2.81–39,831.90, P = 0.017), postoperative time to the first flatus time (OR = 3.79, 95% CI: 1.23–11.68, P = 0.021), total gastrectomy (OR = 0.08, 95% CI: 0.01–0.94, P = 0.044), and patient compliance with ERAS (OR = 0.01, 95% CI: 0–0.09, P < 0.001) were independently associated with prolonged ERAS time.

Conclusions:
Age >80 years, laparoscopic surgery, intraoperative jejunostomy, postoperative time to the first flatus time, total gastrectomy, and patient compliance with ERAS might be factors associated with prolonged ERAS time in gastric cancer patients.
Delay and Disparity in Observed vs Predicted Incidence Rate of Screenable Cancer During the COVID-19 Pandemic
Authors: Romatoski Kelsey S , Chung Sophie H , Kenzik Kelly , Rasic Gordana , Ng Sing Chau , Tseng Jennifer F , Sachs Teviah E 
Published: May 2023

BACKGROUND:
The COVID-19 pandemic resulted in disruption of healthcare services, including cancer screenings, yet data on this are limited. We sought to compare observed and expected cancer incidence rates for screenable cancers, quantifying potential missed diagnoses.

STUDY DESIGN:
Lung, female breast, and colorectal cancer patients from 2010 to 2020 in the National Cancer Database were standardized to calculate annual incidence rates per 100,000. A linear regression model of 2010 through 2019 incidence rates (pre-COVID) was used to calculate predicted 2020 incidence compared with observed incidence in 2020 (COVID) with subanalyses for age, sex, race, ethnicity, and geographic region.

RESULTS:
In total, 1,707,395 lung, 2,200,505 breast, and 1,066,138 colorectal cancer patients were analyzed. After standardizing, the observed 2020 incidence was 66.888, 152.059, and 36.522 per 100,000 compared with the predicted 2020 incidence of 81.650, 178.124, and 44.837 per 100,000, resulting in an observed incidence decrease of –18.1%, –14.6%, and –18.6% for lung, breast, and colorectal cancer, respectively. The difference was amplified on subanalysis for lung (female, 65 or more years old, non-White, Hispanic, Northeastern and Western region), breast (65 or more years old, non-Black, Hispanic, Northeastern and Western region), and colorectal (male, less than 65 years old, non-White, Hispanic, and Western region) cancer patients.

CONCLUSIONS:
The reported incidence of screenable cancers significantly decreased during the COVID-19 pandemic (2020), suggesting that many patients currently harbor undiagnosed cancers. In addition to the human toll, this will further burden the healthcare system and increase future healthcare costs. It is imperative that providers empower patients to schedule cancer screenings to flatten this pending oncologic wave.
Prevalence and epidemiological characteristics of methicillin-resistant Staphylococcus aureus isolated from cattle as a part of the One Health approach
Authors: Venugopal Nimita , Tewari Rituparna , Ganaie Feroze A. , Mitra Susweta , Shome Rajeswari , Shome Bibek R. 
Published: May 2023

In India, limited studies are available on the epidemiological aspects of methicillin-resistant Staphylococcus aureus (MRSA) infections in both animal and human settings. Herein, we investigated the prevalence, antimicrobial resistance profile, and molecular characteristics of MRSA isolates collected from cattle. Out of 66 mecA positive staphylococcus, species-specific multiplex PCR detected 24% (n=16) of isolates as MRSA. Maximum antibiotic resistance was seen against cloxacillin (94%, n=15) and least for enrofloxacin and cephalothin (each 13%, n=2). Overall, 13% (n=2) of MRSA isolates were multidrug-resistant. Molecular characterization by SCCmec typing identified 88% (n=14) of MRSA isolates as type V. Twelve isolates (75%) belonged to novel spa-type t17242, of which 67% (n=8) belonged to agr type I. MLST analysis revealed ST 1687 (50%, n=8) as the most predominant sequence type. Circulation of different MRSA clones among the cattle populace offers a risk of transmission to humans through direct contact, food chain, or environmental contamination. Thus, continuous monitoring of MRSA strains is imperative for early diagnosis and for establishing effective treatment strategies to restrain the disease burden caused by MRSA infections.
Clarity and precision in legal language: Linguistic-discursive analysis of Organic Law 3/2021 on the regulation of euthanasia in Spain
Authors: Hernando-Garreta A. , Centeno C. , Olza I 
Published: May 2023

AbstractSpain has recently regulated the practice of euthanasia through the Organic Law 3/2021. The social relevance of this law clear, as it directly affects fundamental rights enshrined in the Spanish Constitution. The aim of this article is to examine the clarity and precision of the discourse with which the legislator refers to the context of end-of-life care. A linguistic-discursive analysis of the Organic Law 3/2021 is carried out using a mixed methodological approach. The data are categorized and quantified in order to detect potential designative and interpretative problems. We find argumentative inconsistencies in the preamble (n=2) and abundant problematic lexical-semantic choices (n=151) such as vagueness, ambiguity, euphemisms, improper epistemic expressions, evaluative adjectives, verbs of appreciation. Although a legal text must be sufficiently abstract given its generalizable nature, the euthanasia law presents a series of phenomena that affect its interpretation and are potentially negative for its procedural concreteness and effective execution.
Robust estimation of dynamic cerebrovascular reactivity using breath-holding fMRI: application in diabetes and hypertension
Authors: Nanayakkara Nuwan D. , Meusel Liesel-Ann , Anderson Nicole D. , Chen J. Jean 
Published: May 2023

AbstractBreath-holding (BH) tasks during functional magnetic resonance imaging (fMRI) acquisitions are gaining popularity for non-invasive mapping of carbon-dioxide (CO2) driven cerebrovascular reactivity (CVR), which is a valuable clinical marker of vascular function. However, compliance to BH tasks is often unclear, and the ability to record end-tidal CO2often limited, rendering the optimal analysis of BH fMRI data a challenge. In this work, we demonstrate an adaptive data-driven approach for estimating CVR from BH fMRI data that minimizes errors due to subject non-compliance and regional CVR time delay variability. Building on previous work, we propose a frequency-domain-based approach for CVR estimation without the need for end-tidal CO2(PETCO2) recordings. CVR amplitude is estimated in units of %ΔBOLD directly from the data-driven BH frequency. Serious deviations from the designed task paradigm were suppressed and thus did not bias the estimated CVR values. We demonstrate our method in detecting regional CVR amplitude and time-lag differences in a group of 56 individuals, consisting of healthy (CTL), hypertensive (HT) and diabetic-hypertensive (DM+HT) groups of similar ages and sex ratios. The CVR amplitude was lowest in HT+DM, and HT had a lower CVR amplitude than CTL regionally but the voxelwise comparison did not yield statistical significance. Notably, we demonstrate that the voxelwise CVR time delay estimated in Fourier domain is a more sensitive marker of vascular dysfunction than CVR amplitude. While HT+DM seems to confer longer CVR delays, HT seems to confer shorter delays than CTL. These are the first MRI-based observations of CVR time delay differences between diabetic-hypertensive patients and healthy controls. These results demonstrate the feasibility of extracting CVR amplitude and CVR time delay using BH challenges without PETCO2recordings, and the unique clinical value of CVR time-delay information.
Helicobacter pyloriattachment-blocking antibodies protect against duodenal ulcer disease
Authors: Bugaytsova Jeanna A. , Moonens Kristof , Piddubnyi Artem , Schmidt Alexej , Edlund Johan Olofsson , Lisiutin Gennadii , Brännström Kristoffer , Chernov Yevgen A. , Thorel Kaisa , Tkachenko Iryna , Sharova Oleksandra , Vikhrova Iryna , Butsyk Anna , Shubin Pavlo , Chyzhma Ruslana , Johansson Daniel X. , Marcotte Harold , Sjöström Rolf , Shevtsova Anna , Bylund Göran , Rakhimova Lena , Lundquist Anders , Berhilevych Oleksandra , Kasianchuk Victoria , Loboda Andrii , Ivanytsia Volodymyr , Hultenby Kjell , Persson Mats A. A. , Gomes Joana , Matos Rita , Gartner Fátima , Reis Celso A. , Whitmire Jeannette M. , Merrell D. Scott , Pan-Hammarström Qiang , Landström Maréne , Oscarson Stefan , D’Elios Mario M. , Agreus Lars , Ronkainen Jukka , Aro Pertti , Engstrand Lars , Graham David Y. , Kachkovska Vladyslava , Mukhopadhyay Asish , Chaudhuri Sujit , Karmakar Bipul Chandra , Paul Sangita , Kravets Oleksandr , Camorlinga Margarita , Torres Javier , Berg Douglas E. , Moskalenko Roman , Haas Rainer , Remaut Han , Hammarström Lennart , Borén Thomas 
Published: May 2023

SUMMARYThe majority of the world population carry the gastric pathogenHelicobacter pylori. Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism whereH. pyloriattachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority ofH. pyloricarriers. These antibodies block binding of theH. pyloriattachment protein BabA by mimicking BabA’s binding to the ABO blood group glycans in the gastric mucosa. However, many individuals demonstrate low titers of BabA blocking antibodies, which is associated with an increased risk for duodenal ulceration, suggesting a role for these antibodies in preventing gastric disease.
Evaluation of the implementation and effects of management through care and services pathways: A protocol study
Authors: Maillet Lara , Thiebaut Georges Charles , Goudet Anna , Godbout Isabelle , Touati Nassera , Smits Pernelle , Duhoux Arnaud , Breton Mylaine , Abou-Malham Sabina , Couturier Yves , Gilbert Frédéric , Marchand Jean-Sébastien , Denis Jean-Louis 
Published: May 2023

AbstractBackgroundIn 2015, the Government of Quebec undertook a vast reorganization of its health and social services network. This reform mainly aimed to promote and simplify access to services for the population, contributing to the improvement of the quality and safety of care, and increasing the efficiency and effectiveness of the network. Since 2016, several health care organizations (HCOs) have pushed reform even further by developing management through care and service pathways (MCSP). This study aims to identify, in a processual manner, the different factors involved in implementing MCSP in different HCOs, in the turbulent context of the COVID-19 pandemic.MethodThe methodology of this research project is based on developmental evaluation. The objective of developmental evaluation is to guide organizations and actors in the adaptation and development of innovations in complex and turbulent environments. Data will be collected over a three-year period using five strategies: i) organizational questionnaires; ii) analysis of clinical-administrative databases; iii) documentary analysis (grey and scientific literatures); iv) participant observations and v) semi-structured interviews with key actors involved in the implementation of MCSP.DiscussionIn addition to the operationalization of pathways, the implementation of MCSP i) involves transforming the governance of the health care organization both at the strategic and operational levels and ii) is a demanding process that requires changes in practices, modifications in the allocation and configuration of resources and the development of new collaborations between the different actors in the organization, the partners and the users involved in this transformation. Several studies claim that governance innovations can create conditions that are favourable to the emergence of innovations in terms of available services and responding to the needs of populations. This research will develop knowledge of the factors involved in implementing MCSP in complex and turbulent contexts and propose scale-up across the province.
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
Authors: Prabhakar Apurva T. , James Claire D. , Fontan Christian T. , Otoa Raymonde , Wang Xu , Bristol Molly L. , Hill Ronald D. , Dubey Aanchal , Wu Shwu-Yuan , Chiang Cheng-Ming , Morgan Iain M. 
Published: May 2023

AbstractDuring the human papillomavirus 16 life cycle, the E2 protein binds simultaneously to the viral genome and host chromatin throughout mitosis, ensuring viral genomes reside in daughter cell nuclei following cell division. Previously, we demonstrated that CK2 phosphorylation of E2 on serine 23 promotes interaction with TopBP1, and that this interaction is required for optimum E2 mitotic chromatin association and plasmid segregation function. Others have implicated BRD4 in mediating the plasmid segregation function of E2 and we have demonstrated that there is a TopBP1-BRD4 complex in the cell. We therefore further investigated the role of the E2-BRD4 interaction in mediating E2 association with mitotic chromatin and plasmid segregation function. Using a combination of immunofluorescence and our novel plasmid segregation assay in U2OS and N/Tert-1 cells stably expressing a variety of E2 mutants, we report that direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for E2 association with mitotic chromatin and plasmid segregation. We also identify a novel TopBP1 mediated interaction between E2 and the BRD4 extra-terminal (ET) domainin vivo. Overall, the results demonstrate that direct interaction with TopBP1 and the BRD4 CTM are required for E2 mitotic chromatin association and plasmid segregation function. Disruption of this complex offers therapeutic options for targeting segregation of viral genomes into daughter cells, potentially combatting HPV16 infections, and cancers that retain episomal genomes.ImportanceHPV16 is a causative agent in around 3-4% of all human cancers and currently there are no anti-viral therapeutics available for combating this disease burden. In order to identify new therapeutic targets, we must increase our understanding of the HPV16 life cycle. Previously, we demonstrated that an interaction between E2 and the cellular protein TopBP1 mediates the plasmid segregation function of E2, allowing distribution of viral genomes into daughter nuclei following cell division. Here, we demonstrate that E2 interaction with an additional host protein, BRD4, is also essential for E2 segregation function, and that BRD4 exists in a complex with TopBP1. Overall, these results enhance our understanding of a critical part of the HPV16 life cycle and presents several therapeutic targets for disruption of the viral life cycle.
Scaffold-level genome assemblies of two parasitoid biocontrol wasps reveal the parthenogenesis mechanism and an associated novel virus
Authors: Inwood S.N , Skelly J , Guhlin J , Harrop T , Goldson S , Dearden P.K 
Published: May 2023

AbstractBackgroundBiocontrol is a key technology for the control of pest species.Microctonusparasitoid wasps (Hymenoptera: Braconidae) have been released in Aotearoa New Zealand as biocontrol agents, targeting three different pest weevil species. Despite their value as biocontrol agents, no genome assemblies are currently available for theseMicroctonuswasps, limiting investigations into key biological differences between the different species and strains.Methods and findingsHere we present high-quality genomes forMicroctonus hyperodaeandMicroctonus aethiopoides, assembled with short read sequencing and Hi-C scaffolding. These assemblies have total lengths of 106.7 Mb forM. hyperodaeand 129.2 Mb forM. aethiopoides, with scaffold N50 values of 9 Mb and 23 Mb respectively. With these assemblies we investigated differences in reproductive mechanisms, and association with viruses betweenMicroctonuswasps. Meiosis-specific genes are conserved in asexualMicroctonus, within-situhybridisation validating expression of one of these genes in the ovaries of asexualMicroctonus aethiopoides. This implies asexual reproduction in theseMicroctonuswasps involves meiosis, with the potential for sexual reproduction maintained. Investigation of viral gene content revealed candidate genes that may be involved in virus-like particle production inM. aethiopoides, as well as a novel virus infectingM. hyperodae, for which a complete genome was assembled.Conclusion and significanceThese are the first published genomes forMicroctonuswasps used for biocontrol in Aotearoa New Zealand, which will be valuable resources for continued investigation and monitoring of these biocontrol systems. Understanding the biology underpinningMicroctonusbiocontrol is crucial if we are to maintain its efficacy, or in the case ofM. hyperodaeto understand what may have influenced the significant decline of biocontrol efficacy. The potential for sexual reproduction in asexualMicroctonusis significant given that empirical modelling suggests this asexual reproduction is likely to have contributed to biocontrol decline. Furthermore the identification of a novel virus inM. hyperodaehighlights a previously unknown aspect of this biocontrol system, which may contribute to premature mortality of the host pest . These findings have potential to be exploited in future in attempt to increase the effectiveness ofM. hyperodaebiocontrol.
The circular potential of a Bio-District: indicators for waste management
Authors: Poponi Stefano , Ruggieri Alessandro , Pacchera Francesco , Arcese Gabriella 
Published: May 2023

PurposeThis work aims to assess the potential of a Bio-District as a model for applying the circular economy concerning the waste scope. It aims to understand the capability of organic farms to manage waste with a circular perspective, starting with the use of indicators that directly or indirectly impact the waste scope.Design/methodology/approachThis study is based on previous work that identified and systematised the circular indicators of the agri-food sector within a dashboard. With this research as a basis, the indicators within the waste scope in the dashboard were extracted. Cross-linked indicators with an indirect connection to the waste scope were also systematised and tested in a case study. Primary and secondary data were used for the study. The primary data came from a semi-structured interview, and the secondary data were from official databases.FindingsThe work highlights two important results. The first allows the definition of a subclassification of indicators by product and organisation, extracting those with a cross-linked characteristic concerning the waste scope. Secondly, the indicators' application shows the farm's circular and waste valorisation potential within the Bio-District. The study also made it possible to test a new indicator, the “Potential Energy Biomass Recovery”, to measure the farm's potential to produce energy from waste.Originality/valueThis research proposes a new circular economy approach to evaluate waste management in the agri-food sector.
The impact of digital technologies on business competitiveness: a comparison between Latin America and Europe
Authors: Bacca-Acosta Jorge , Gómez-Caicedo Melva Inés , Gaitán-Angulo Mercedes , Robayo-Acuña Paula , Ariza-Salazar Janitza , Mercado Suárez Álvaro Luis , Alarcón Villamil Nelson Orlando 
Published: May 2023

Purpose
This study aims to examine how the adoption of digital technologies affects the business competitiveness of countries in Latin American and European countries.

Design/methodology/approach
This study used a structural model based on factors representing the pillars of the Global Competitiveness Index: financial system, adoption of information and communication technologies (ICT), skills, labor market, product market, macroeconomic stability, business dynamism and gross domestic product (GDP) purchasing power parity (PPP) as a percentage of the total world value. The authors considered 17 Latin American and 28 European countries. The model was analyzed by partial least squares-structural equation modeling.

Findings
ICT adoption in Latin American countries is a strong predictor of business dynamism (66% of the variance), skills (81% of the variance), product market (75% of the variance), labor market (42% of the variance) and financial system (49% of the variance). Similarly, ICT adoption in European countries is a strong predictor of business dynamism (35.6% of the variance), skills (72.2% of the variance), product market (51.6% of the variance), labor market (81.7% of the variance, but with a negative path coefficient) and financial system (38% of the variance).

Practical implications
Latin American countries should create policies to build skills to increase ICT adoption, and improve business and labor market dynamism. A theoretical implication is that the authors propose two structural models based on the GCI that best explains competitiveness in Europe and Latin America.

Originality/value
Using GCI data, the authors present empirical evidence on the predictors of competitiveness across 17 Latin American and 28 European countries with a special focus on the adoption of digital technologies.
An unconditionally energy-stable scheme for the convective heat transfer equation
Authors: Liu Xiaoyu , Dong Suchuan , Xie Zhi 
Published: May 2023

Purpose
This paper aims to present an unconditionally energy-stable scheme for approximating the convective heat transfer equation.

Design/methodology/approach
The scheme stems from the generalized positive auxiliary variable (gPAV) idea and exploits a special treatment for the convection term. The original convection term is replaced by its linear approximation plus a correction term, which is under the control of an auxiliary variable. The scheme entails the computation of two temperature fields within each time step, and the linear algebraic system resulting from the discretization involves a coefficient matrix that is updated periodically. This auxiliary variable is given by a well-defined explicit formula that guarantees the positivity of its computed value.

Findings
Compared with the semi-implicit scheme and the gPAV-based scheme without the treatment on the convection term, the current scheme can provide an expanded accuracy range and achieve more accurate simulations at large (or fairly large) time step sizes. Extensive numerical experiments have been presented to demonstrate the accuracy and stability performance of the scheme developed herein.

Originality/value
This study shows the unconditional discrete energy stability property of the current scheme, irrespective of the time step sizes.