bluuebunny/crossref_metadata_2025_split huggingface dataset:
Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04)
Authors: Mohan Arathi , Griffith Kent A. , Wuchu Fulei , Zhen David B. , Kumar-Sinha Chandan , Crysler Oxana , Hsiehchen David , Enzler Thomas , Dippman Dominique , Gunchick Valerie , Achreja Abhinav , Animasahun Olamide , Choppara Srinadh , Nenwani Minal , Chinnaiyan Arul M. , Nagrath Deepak , Zalupski Mark M. , Sahai Vaibhav 
Published: April 2023

Abstract

Purpose:
Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC).

Patients and Methods:
Cell viability assays of devimistat ± gemcitabine and cisplatin (GC) were performed and the effect of devimistat on mitochondrial respiration via oxygen consumption rate (OCR) was evaluated. A phase Ib/II trial was initiated in patients with untreated advanced BTC. In phase Ib, devimistat was infused over 2 hours in combination with GC on days 1 and 8 every 21 days with a primary objective to determine the recommended phase II dose (RP2D). Secondary objectives included safety, overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).

Results:
In vitro, devimistat with GC had a synergistic effect on two cell lines. Devimistat significantly decreased OCR at higher doses and in arms with divided dosing. In the phase Ib trial, 20 patients received a median of nine cycles (range, 3–19). One DLT was observed, and the RP2D of devimistat was determined to be 2,000 mg/m2 in combination with GC. Most common grade 3 toxicities included neutropenia (n = 11, 55%), anemia (n = 4, 20%), and infection (n = 3, 15%). There were no grade 4 toxicities. After a median follow-up of 15.6 months, ORR was 45% and median PFS was 10 months (95% confidence interval, 7.1–14.9). Median OS is not yet estimable.

Conclusions:
Devimistat in combination with GC is well tolerated and has an acceptable safety profile in patients with untreated advanced BTC.
Oligometastases: Characterizing the Role of Epigenetic Regulation of Epithelial–Mesenchymal Transition
Authors: Katipally Rohan R. , Pitroda Sean P. , Weichselbaum Ralph R. , Hellman Samuel 
Published: April 2023

Abstract
The “oligometastasis” hypothesis proposes that metastases exist as a spectrum and are not always disseminated. According to this theory, a subset of patients with metastatic disease could benefit from aggressive local therapies. However, the identification of patients most likely to exhibit an oligometastatic phenotype remains challenging. Recent literature focusing on basic and translational studies has identified novel epigenetic regulators of epithelial–mesenchymal transition (EMT) and the emergence of a spectrum of metastatic behavior. Herein, we review these scientific advances and suggest that the spectrum of metastatic virulence produced by these epigenetic mechanisms broadly contributes to the emergence of clinically evident “oligometastases.” Epigenetic regulation of EMT programs can result in a spectrum of cell trajectories (e.g., quasi-mesenchymal and highly mesenchymal states) with differential propensity to develop metastases. We propose that quasi-mesenchymal cell states may be associated with a polymetastatic phenotype, whereas highly mesenchymal cell states may be associated with a more oligometastatic phenotype. The mechanisms governing epigenetic regulation of EMT and its array of intermediate states are multifaceted and may contribute to the development of the metastatic spectrum observed clinically. Within this context, translational studies that support the role of EMT and its epigenetic regulation are discussed. Continued translation of these mechanistic discoveries into novel biomarkers may help optimally select patients most likely to exhibit an oligometastatic phenotype and benefit from aggressive local therapies, such as surgery, radiotherapy, and other ablative procedures.
Syntax and Pronominal Competence in Post-Classical Greek and the Septuagint
Authors: Dhont Marieke 
Published: April 2023

Abstract
Scholars are often struck by the frequent use of pronouns in the Septuagint, particularly placed in postposition, linking both these aspects to the translation technique or the competency of the translators. In this article, I argue that pronominal usage in the Septuagint can be linked to developments in post-classical Greek more so than to interference from the source text. I focus particularly on pronominal usage in relation to syntax and word order to show that the traditional approach to translation technique has limited our understanding of linguistic features in the Septuagint, and deal with questions that arise from an approach to the Septuagint as reflective of post-classical Greek, namely, what can pronouns in the Septuagint tell us about the educational background of the translators and their translation methods?
Plectrocnemia aristovi sp. nov., a new fossil species of Polycentropodidae (Insecta: Trichoptera) from Eocene Rovno amber
Authors: MELNITSKY STANISLAV I. , IVANOV VLADIMIR D. 
Published: April 2023

Forty-five species of caddisflies are known from Rovno amber (Ivanov et al., 2016; Perkovsky, 2017; Melnitsky et al., 2021a–c). The new 24 caddisfly species from 8 families (Psychomyiidae – 1, Polycentropodidae – 11, Ecnomidae – 2, Philopotamidae – 2, Hydroptilidae – 4, Phryganeidae – 1, Lepidostomatidae – 1, Leptoceridae – 3) of Rovno amber are described in recent papers of last decade (Melnitsky & Ivanov, 2010, 2013, 2016 a, b; Melnitsky et al., 2021a–c). The family Polycentropodidae includes more than 910 species in the world fauna, of which about 100 are fossils (Morse, 2023). The genus Plectrocnemia contains over 160 species; representatives of this genus are widespread in the Holarctic and Oriental realms. The genus Plectrocnemia is represented by 27 fossil species in the Paleogene resins of Europe, five of which are noted in Rovno amber (Melnitsky et al., 2021a). Three species: Plectrocnemia nastigermania Melnitsky & Ivanov, 2013, Plectrocnemia ucrainum Melnitsky & Ivanov, 2013, and Plectrocnemia kirmikhia Melnitsky, Ivanov & Perkovsky, 2021 are endemic to Rovno amber. Here we describe a new species from the genus Plectrocnemia from the Rovno amber.
Comparison of Three Radar-Based Precipitation Nowcasts for the Extreme July 2021 Flooding Event in Germany
Authors: Saadi Mohamed , Furusho-Percot Carina , Belleflamme Alexandre , Trömel Silke , Kollet Stefan , Reinoso-Rondinel Ricardo 
Published: April 2023

Abstract
Quantitative precipitation nowcasts (QPN) can improve the accuracy of flood forecasts, especially for lead times up to 12 h, but their evaluation depends on a variety of factors, namely, the choice of the hydrological model and the benchmark. We tested three precipitation nowcasting techniques based on radar observations for the disastrous mid-July 2021 event in seven German catchments (140–1670 km2). Two deterministic [advection-based and spectral prognosis (S-PROG)] and one probabilistic [Short-Term Ensemble Prediction System (STEPS)] QPN with a maximum lead time of 3 h were used as input to two hydrological models: a physically based, 3D-distributed model (ParFlowCLM) and a conceptual, lumped model (GR4H). We quantified the hydrological added value of QPN compared with hydrological persistence and zero-precipitation nowcasts as benchmarks. For the 14 July 2021 event, we obtained the following key results. 1) According to the quality of the forecasted hydrographs, exploiting QPN improved the lead times by up to 4 h (8 h) compared with adopting zero-precipitation nowcasts (hydrological persistence) as a benchmark. Using a skill-based approach, obtained improvements were up to 7–12 h depending on the benchmark. 2) The three QPN techniques obtained similar performances regardless of the applied hydrological model. 3) Using zero-precipitation nowcasts instead of hydrological persistence as benchmark reduced the added value of QPN. These results highlight the need for combining a skill-based approach with an analysis of the quality of forecasted hydrographs to rigorously estimate the added value of QPN.
Effect of CADM1 on TPF-induced chemotherapy in laryngeal squamous cell carcinoma
Authors: Nie Jiani , Li Lianhe , Tan Fuxian , Wang Hongmei , Wang Hongmin , Zou Liangyu , Wen Zhenlei 
Published: April 2023

Objectives To explore the relationship between CADM1 expression and sensitivity to TPF-induced chemotherapy in laryngeal squamous cell carcinoma (LSCC) patients, then investigate its potential mechanisms. Methods Differential CADM1 expression was examined in chemotherapy-sensitive and chemotherapy-insensitive LSCC patient samples after TPF-induced chemotherapy using microarray analysis. Receiver operating characteristic (ROC) curve analysis and bioinformatics approaches were used to investigate the diagnostic value of CADM1. Small interfering RNAs (siRNAs) were used to knock down CADM1 expression in an LSCC cell line. Differential CADM1 expression was compared by qRT-PCR assays in 35 LSCC patients treated with chemotherapy, including 20 chemotherapy-sensitive and 15 chemotherapy-insensitive patients. Results Public database and primary patient data both suggest that CADM1 mRNA is expressed at lower levels in chemotherapy-insensitive LSCC samples, suggesting its potential usefulness as a biomarker. Knockdown of CADM1 with siRNAs led to decreased sensitivity of LSCC cells to TPF chemotherapy. Conclusions Upregulation of CADM1 expression can alter the sensitivity of LSCC tumors to TPF induction chemotherapy. CADM1 is a possible molecular marker and therapeutic target for induction chemotherapy in LSCC patients.
Long-term volume reduction in renal angiomyolipomas embolized by gelatin sponge particles with or without supplementary microcoil embolization
Authors: Zhang Xixi , Kuwatsuru Ryohei , Toei Hiroshi , Yashiro Daisuke , Sokooshi Hideaki , Kuwatsuru Yoshiki 
Published: April 2023

Objective To examine the effect of supplementary microcoil embolization on the long-term progression of angiomyolipomas embolized using gelatin sponge particles (GSPs). Methods This retrospective study included 29 unruptured angiomyolipomas in 25 patients, treated by complete embolization and radiological follow-up for ≥3 years. Embolization was performed using GSPs and supplementary microcoils. Supplementary microcoil embolization affecting >90% of the tumor vasculature was defined as microcoil embolization. Tumor volumes pre- and post-embolization were measured by computed tomography or magnetic resonance imaging. Results Eleven tumors received supplementary microcoil embolization and 18 tumors did not. Relative tumor reduction at >3 years post-embolization was significantly greater in tumors with supplementary microcoil embolization compared with tumors without microcoil embolization (81% ± 8% vs. 55% ± 29%). Fourteen tumors tended to show volume regrowth and the volumes of the remaining 15 tumors continued to decline. Tumors without supplementary microcoil embolization were more likely to show volume regrowth during follow-up than tumors with supplementary microcoil embolization (78% vs. 0%, respectively). Conclusions When using a combination of GSPs and microcoils, supplementary microcoil embolization should be carried out to ensure maximum long-term reduction in tumor volume in patients with angiomyolipomas.
Make a good impression: Recommend different products for self-presentation
Authors: Wang Lili , Chen Hanyu (Yuki) , Zhang Xuan 
Published: April 2023

Word-of-mouth (WOM) has become one of the most important ways consumers obtain and deliver self-image. However, little research has investigated how product type influences consumers’ WOM intention through self-presentation motivation. Across six studies, this research explores how, why, when, and for whom the product type matters in self-presentation and WOM. Specifically, Study 1A and Study 1B demonstrate that consumers are more likely to engage in WOM for experiential (vs material products) regardless of the type of WOM. Study 2 investigates whether this effect is mediated by promotion-oriented rather than prevention-oriented self-presentation. Finally, three moderator studies, including self-affirmation (Study 3), materialism (Study 4), and need for uniqueness (Study 5), illustrate when and whose WOM intention is more likely to be influenced. This research contributes to theory and practice in impression management and the growing literature on WOM intention. JEL Classification: M310 Marketing and M370 Advertising
An Examination of the Non-linear Relationship Between Cognition and Total Hemoglobin Among the Cognitively Normal Older Adults by Gender
Authors: Min Se Hee , Schnall Rebecca , Lee Chiyoung , Topaz Maxim 
Published: April 2023

Objectives: This exploratory study aimed to identify the potential non-linear relationship between hemoglobin (Hgb) and cognition among cognitively normal older adults and how this relationship differs in terms of gender in generalized additive models (GAM). Methods: This is a secondary data analysis using Wave II (2010–2011) data from the National Social Life, Health, and Aging Project. A generalized additive model was used to understand the non-linear relationship between Hgb and cognition, and to identify critical Hgb point related to cognition. Results: While both genders had a non-linear association between Hgb and cognition, the degree of non-linearity was more pronounced in male older adults with EDF value close to 2. The inflection point of 15.10 g/dL for male older adults and inflection point of 11.72 g/dL for female older adults were obtained. Conclusion: Further studies are needed to validate these results and develop precision medicine approaches to integrate these results into clinical practice.
A global view on digital legal deposit: what could be learned?
Authors: Neshat Narges , Ghasemi Rahim 
Published: April 2023

Aim Procedures for legal deposit of the print material are well established and widely practiced. Such procedures, however, are not necessarily applicable to the digital environment, mainly because bibliographic specifications of print material do not match those of digital objects and digital environment. The history of legal deposit of publications in Iran goes back to 1906. Since then, the press, publishers, public and private institutions are required to deposit one or more copies of their published material to the National Library of Iran (NLIR). However, reports have always indicated incomplete deposit or lack of coherent and comprehensive policies, especially with regard to digital resources. The present study aims to propose a framework for NLIR by comparing several national libraries. Methodology This research examined the policies and practices of 10 large national libraries that according to the World atlas (2018) have been ranked the highest in terms of the number and variety of resources. They were the Library of Congress, the British Library, National Library and Archives of Canada (LAC), and national libraries of France, Germany, Denmark, Spain, Australia, Japan, and China. The data related to digital legal deposit implementation was collected from various sources including directories; official publications of international organizations, national legal deposit laws and regulations. Findings A global trend towards legal deposit to cover digital publications and preservation of comprehensive national archives is developing. In Iran, there was no mechanisms for identification, selection and deposit of digital materials either do not exist or are inappropriate for some types of publications. Conclusion National libraries and other libraries are at the forefront of research and development in the field of legal deposit. In this research, an effort was made to design and propose a framework for depositing digital material at NLIR drawing on the policies and practices of the top 10 national libraries. The proposed framework has two parts. The first includes elements such as introduction, general principles, resources comprehensiveness, legal deposit method, the origin of publications, collaboration and partnership, and legal considerations. In the second part -the plan-areas addressed in the first part are discussed in detail.
Solvent Absorption by Carbon Fibre Reinforced PEEK Laminates
Authors: Pritchard Geoffrey , Randies Steven J. 
Published: April 2023

The absorption of organic liquids by polyaryl ether-etherketone (PEEK) was investigated. Experiments with carbon fibre reinforced PEEK immersed in liquids of linear and cyclic molecules at 23°±2°C show that three important parameters (molecular size, shape, and polarity) have important effects on the diffusion rate. For the purposes of this study, using fibrous laminates rather than unreinforced polymers ensured matrix samples which were well-characterised and representative of practical materials with respect to crystallinity. Special attention was directed to alkanes and alcohols. Three dimensional plots of weight absorption against hydrogen bonding capacity and the product of molar volume and solubility parameter mismatch are presented. Implications for solvent resistance are suggested.
Experimental Verification on Simulating Shrinkage and Warpage of Thin Compression Moulded SMC Parts
Authors: Osswald Tim A. , Sun Esther M. , Tseng Shi-Chang 
Published: April 2023

One of the important issues in designing plastic parts, especially those that are fibre reinforced, is to predict shrinkage and warpage of the moulded parts. Shrinkage and warpage result from material inhomogeneities caused by flow induced fibre orientation, curing, poor thermal mould lay-out, and processing conditions. Shrinkage and warpage are directly related to residual stresses which result from locally varying strain fields that occur during the curing or solidification stage of a manufacturing process. This paper presents research conducted in numerical simulation and experimental investigation of the shrinkage and warpage of compression moulded fibre reinforced composite parts. A coupled temperature and stress simulation program with a three-noded shell element formulation was developed to calculate the residual stress build-up during curing and solidification stages of a compression moulding process. The numerical model also included the spring forward effect present in curved parts. Correlation between experimentally measured and simulated shrinkage and warpage of the moulded composites is presented for various geometries and processing conditions. The simulated results have shown excellent agreement with the experimental data. The results indicated that fibre orientation distributions which vary with different charge locations have a significant effect on the final warpage. Shrinkage and warpage can be substantially reduced by using lower shrinkage polyester matrix or by increasing the fibre content within the charge. Unsymmetric curing caused by uneven mould temperatures leads to a thermal moment which could increase or possibly even reduce warpage of a finished part. Preheating or increasing the fibre content of the charge could also help reduce the final warpage. The spring forward effect was found to be significant in large-curved parts.
Studies on Self-Crosslinking Blend System Based on Polychloroprene and Polyacrylamide: Cure Characteristics, Physical Properties and Degradation
Authors: Kole S. , Tripathy D.K. , De P.P. 
Published: April 2023

Polychloroprene and polyacrylamide form a self-crosslinking blend during mixing and moulding in the temperature range 140 to 190°C and mis inter-crosslinking is revealed by a torque rise in the rheometric studies. The nature of the stress-strain curves of the blend indicates the generation of a bonded structure where one soft matrix is bonded with a rigid phase and the bonding fails after a critical loading. The results of hysteresis measurements are in agreement with a bonded structure. The SEM study shows that the majority of the polyacrylamide particles are covered with a layer of rubber matrix. It also shows the distribution of particles and the extent of breakdown of the particles in various blends. The SEM observations are also in line with interfacial bonding and help in understanding the physical properties of various blends based on the extent of inter-crosslinking reaction. Thermogravimetric analysis of aqueous solutions, cast film, and dry powdered of polyacrylamide confirms the role of moisture in polyacrylamide degradation. It also confirms that although polychloroprene imparts some water resistance to the polyacrylamide component, it still remains degradable by water.
NDT of Composite Materials - Problems and Solutions 1. NDT as a Source of Information
Authors: Matiss I. 
Published: April 2023

This introductory paper is devoted to highlighting distinctive features of the non-destructive testing (NDT) techniques used in the study of polymers and composite materials. More than 30 years experience at the Institute of Polymer Mechanics has shown that success in the application of NDT to advanced materials depends crucially on the optimal choice of the technique and on the skill of the operator. The reason for a special approach to testing of these materials is that a number of specific features characterise composite structures. Analysis of these features, recommendations to increase the reliability and the accuracy of the NDT methods and a search for new testing techniques are the major areas of research carried out in the Institute. The following topics will be covered: 1. Non-destructive testing as a source of information. 2. Relaxation spectrometry for the structural study of polymers and polymer composites. 3. Modelling of dielectric relaxation phenomena.
Preparation and Characterisation of Polyacrylic Acid Leucaena Gum as a Thickener in Reactive Dye Printing Pastes
Authors: Kantouch F. , Ragheb A. 
Published: April 2023

Polyacrylic acid-leucaena gum was prepared by the polymerisation of acrylic acid on leucaena gum using potassium persulphate as initiator. The rheological properties of the gums and their utilisation as thickening agents in printing cotton fabrics with reactive dyes were investigated. It was found that polyacrylic acid-leucaena gum pastes are characterised by a non-Newtonian pseudoplastic behaviour. The apparent viscosity depends on the amount of acrylic acid. Cotton fabric samples printed with cibacron blue 3R acquire soft handle and colour fastness properties nearly identical with those printed using sodium alginate paste; the highest colour strength was obtained using a mixture of polyacrylic acid/leucaena gum with sodium alginate at a ratio of 1:3 w/w.