bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of remdesivir on SARS-CoV-2 viral dynamics and mortality in viraemic patients hospitalized for COVID-19
Authors: Hagman Karl , Hedenstierna Magnus , Widaeus Jacob , Arvidsson Emelie , Hammas Berit , Grillner Lena , Jakobsson Jan , Gille-Johnson Patrik , Ursing Johan 
Published: September 2023

Abstract

Background
Studies on the antiviral effects of remdesivir have shown conflicting results. SARS-CoV-2 viraemia could identify patients in whom antiviral treatment may be particularly beneficial.

Objectives
To investigate antiviral effects and clinical outcomes of remdesivir treatment in viraemic patients.

Methods
Viraemic patients hospitalized for COVID-19 with ratio of arterial oxygen partial pressure to fractional inspired oxygen of ≤300, symptom duration ≤10 days, and estimated glomerular filtration rate ≥30 mL/min were included in a cohort. The rate of serum viral clearance and serum viral load decline, 60 day mortality and in-hospital outcomes were estimated. A subgroup analysis including patients with symptom duration ≤7 days was performed.

Results
A total of 318 viraemic patients were included. Thirty-three percent (105/318) received remdesivir. The rate of serum viral clearance [subhazard risk ratio (SHR) 1.4 (95% CI 0.9–2.0), P = 0.11] and serum viral load decline (P = 0.11) were not significantly different between remdesivir-treated patients and controls. However, the rate of serum viral clearance was non-significantly higher [SHR 1.6 (95% CI 1.0–2.7), P = 0.051] and the viral load decline was faster (P = 0.03) in remdesivir-treated patients with symptom duration ≤7 days at admission. The 60 day mortality [HR 1.0 (95% CI 0.6–1.8), P = 0.97] and adverse in-hospital outcomes [OR 1.4 (95% CI 0.8–2.4), P = 0.31] were not significantly different between remdesivir-treated patients and controls.

Conclusions
Remdesivir treatment did not significantly change the duration of SARS-CoV-2 viraemia, decline of serum viral load, 60 day mortality or in-hospital adverse outcomes in patients with ≤10 days of symptoms at admission. Remdesivir appeared to reduce the duration of viraemia in a subgroup of patients with ≤7 days of symptoms at admission.
Effects of the F94L myostatin gene mutation in beef × dairy crossed cattle on muscle fiber type, live performance, carcass characteristics, and boxed beef and retail cut yields
Authors: Waller Bryanne E , Garcia Samuel R , Fuerniss Luke K , Johnson Bradley J , Woerner Dale R , Wulf Duane M 
Published: September 2023

Abstract
Producer live performance data and carcasses from steers (n = 116) resulting from the mating of four Limousin/Angus sires heterozygous for the F94L myostatin mutation to Jersey/Holstein dams were utilized to evaluate the effects of one copy of the F94L allele on live performance, carcass traits and USDA grades, and boxed beef and retail yields. Slaughter data were collected at time of harvest and carcass data were collected 48 hours postmortem. One side from each of the 58 carcasses was fabricated into boxed beef and retail cuts by experienced lab personnel 5–8 d postmortem. One copy of the F94L allele did not affect gestation length, birth weight, percentage of unassisted births, feedlot average daily gain, live weight at harvest, hot carcass weight, or dressing percentage (P &gt; 0.05). Muscle fiber analysis indicated that the increase in muscularity by the F94L allele in the semitendinosus and longissimus was likely due to hyperplasia as there was a 19% increase in the quantity of myosin heavy chain type IIA and IIX fibers in the semitendinosus (P &lt; 0.05) with no effect on muscle fiber size (P &gt; 0.05). Carcasses from steers with one F94L allele had larger ribeye areas (99.2 vs. 92.3 sq.cm.), greater ribeye width:length ratios (0.498 vs. 0.479), lower USDA yield grades (2.21 vs. 2.66), and lower marbling scores (438 vs. 480) (P &lt; 0.05). Additionally, for boxed beef yields, one F94L allele, vs. zero F94L alleles, increased (P &lt; 0.05) 85/15 trimmings (+0.59%), top round (+0.28%), strip loin (+0.12%), eye round (+0.11%), tenderloin (+0.07%), boneless foreshank (+0.07%), cap/wedge (+0.06%), and tri-tip (+0.04%). Overall, carcasses from steers with one F94L allele had a greater boxed beef yield (+1.06%), boxed beef plus 85/15 trimmings yield (+1.65%), and total retail cuts plus ground beef 85/15 yield (+1.78%) than carcasses from steers with zero F94L alleles (P &lt; 0.05). One copy of the F94L allele utilized in beef-on-dairy breeding system had no significant impact on live performance traits but resulted in lower marbling scores and increased muscularity as evidenced through larger, more beef-shaped ribeyes, lower USDA yield grades, and greater carcass cutout yields (both boxed beef and retail yields).
Early- and mid-lactation milk traits are associated with piglet growth during lactation
Authors: Rempel Lea A , Oliver William T , Miles Jeremy R 
Published: September 2023

Abstract
Preweaning piglet growth is tied to milk quality and consumption. To determine the relationship of milk traits from parity 1–4 dams and piglet growth, early- and mid-lactation (day 2 and day 16) milk samples were collected from 48 litters and analyzed for protein, fat, somatic cell count (SCC), lactose, other solids (solids excluding protein and fat), total solids, and milk urea nitrogen (MUN). There were no interactions of parity by day therefore only main effects were tested. Milk volume and percent MUN were greatest (P &lt; 0.05) from fourth parity dams. Nulliparous dams had elevated (P &lt; 0.05) SCC. Several milk traits were different by day. Percent milk protein, fat, and total solids were greater (P &lt; 0.05) from day 2 milk, while percent milk lactose and other solids were greater (P &lt; 0.05) from day 16 milk. Each milk trait was categorically identified as high, moderate, or low at ¼, ½, or ¼ distribution, respectively. Mixed models were used to determine the association of individual milk traits with piglet lactation growth (gain calculated from body weights at birth, day 10, and day 25 weaning; WN). Moderate levels of day 2 milk protein were associated with the greatest (P &lt; 0.05) gain during lactation in comparison to low and high levels. High levels of day 2 milk lactose and day 2 other solids were both related (P &lt; 0.05) to piglet gain over the lactation period. Evaluation of day 16 milk traits with piglet gain over lactation indicated high levels of fat, other solids, and total solids had the greatest (P &lt; 0.05) gain in comparison to moderate and low levels of each trait. Within phase of lactation weight gain, association of day 2 or day 16 milk traits with early weight gain (birth to day 10) or late weight gain (day 10 to WN) were performed. The greatest (P &lt; 0.05) early weight gains were associated with moderate levels of day 2 protein, high levels of day 2 lactose and day 2 other solids, and low levels of day 2 MUN. High levels of day 2 milk lactose and day 16 milk fat were associated (P &lt; 0.05) with piglet gain during late lactation (day 10 to weaning). Genetic selection or improved management that allows for favorable milk traits at critical periods of lactation for improved weight gain will improve pig production.
Urinary bladder matrix for lower extremity split-thickness skin graft donor site
Authors: Bormann Sydney , Lawrence Zachary , Karu Heather 
Published: September 2023

Abstract
Split-thickness skin grafts (STSG) are commonly used to treat soft-tissue defects. Harvesting a STSG creates an additional partial thickness wound at the donor site which must be managed. Many dressings are commercially available for the management of STSG donor sites; however, there is no evidence-based consensus on optimal dressing for site management. Urinary bladder matrix (UBM) is an extracellular matrix that acts as a structural support for tissue remodeling and provides molecular components for repair. Common clinical applications of UBM include coverage of deep wounds, burns, and irradiated skin. Skin grafting from the lower extremities poses a challenge due to the increased dermal tension. UBM-based reconstruction is an alternative method of managing lower extremity skin graft donor sites. This case study demonstrates the use of UBM in the reconstruction of a STSG donor site of the anterolateral thigh, which resulted in satisfactory healing, no pain, and excellent cosmetic and functional outcomes.
Single pulse emission from PSR B0809+74 at 150 MHz using Polish LOFAR station
Authors: Basu Rahul , Lewandowski Wojciech , Kijak Jarosław , Bartosz Śmierciak , Soida Marian , Błaszkiewicz Leszek , Krankowski Andrzej 
Published: September 2023

ABSTRACT
We report the observations of single pulse emission from the pulsar B0809+74 at 150 MHz using the Polish LOFAR station, PL-611. The three major phenomena of subpulse drifting, nulling, and mode changing associated with single pulse variations are prominently seen in these observations. The pulsar has a single-component conal profile and the single pulses are primarily in the ‘normal’ drift mode with periodicity (P3) 11.1 ± 0.5 P for 96 per cent of the observing duration, while the shorter duration ‘slow-drift’ mode has P3 = 15.7 ± 1.2 P. We were able to measure the phase behaviour associated with drifting from the fluctuation spectral analysis that showed identical linear phase variations across the pulse window for both modes despite their different periodic behaviour. Earlier studies reported that the transitions from the normal state to the slow-drift mode were preceded by the presence of nulling with typical durations of 5 to 10 periods. Our observations however seem to suggest that the transition to nulling follows shortly after the pulsar switches to the slow-drift mode and not at the boundary between the modes, with one instance of complete absence of nulling between mode switching. In addition, we also detected a second type of short-duration nulls not associated with the mode changing that showed quasi-periodic behaviour with periodicity PN ∼ 44 ± 7. The variety of features revealed in the single pulse sequence makes PSR B0809+74 an ideal candidate to understand the physical processes in the Partially Screened Gap dominated by non-dipolar magnetic fields.
Formation of the hydrogen line 21-cm in Dark Ages and Cosmic Dawn: dependences on cosmology and first light
Authors: Novosyadlyj Bohdan , Kulinich Yurii , Milinevsky Gennadi , Shulga Valerii 
Published: September 2023

ABSTRACT
We analyse the formation of the redshifted hyperfine structure line 21-cm of hydrogen atom in the Dark Ages, Cosmic Dawn, and Reionization epochs. The evolution of the global differential brightness temperature in this line was computed to study its dependence on the values of cosmological parameters and physical conditions in the intergalactic medium. Variations of the depth of the Dark Ages absorption line at z ∼ 80 with variations of the cosmological parameters Ωb, Ωcdm, ΩΛ, ΩK, and H0 are studied. The standard model with post-Planck parameters predicts a value of the differential brightness temperature in the centre of the absorption line ∼30–50 mK. The profile of this line can be quite another in the non-standard cosmological models, which include the annihilating or decaying dark matter, a primordial stochastic magnetic field, etc. It can be shallower or be an emission bump instead of an absorption trough. It is also shown that the position and depth of the Cosmic Dawn absorption line formed at 10 &lt; z &lt; 30, due to the Wouthuysen–Field effect, is mainly defined by the spectral energy distribution of the first sources of light. If reionization occurs at zri = 7 ± 1, then the differential brightness temperature in the centre of this line is ∼80 mK. During the reionization, the emission with an amplitude of ∼20 mK is possible. It is also shown that the temperature, density, and degree of ionization of the baryonic component are decisive in calculating the intensity of the 21-cm absorption/emission line from these epochs.
The effect of intra-articular steroid injection on the cartilage and tendon thicknesses in juvenile idiopathic arthritis
Authors: Şahin Nihal , Özdemir Çiçek Sümeyra , Paç Kısaarslan Ayşenur , Dursun İsmail , Poyrazoğlu Muammer Hakan , Düşünsel Ruhan 
Published: September 2023

ABSTRACT

Objectives
Intra-articular corticosteroid injection (IACI) is a safe first-line or adjunct therapy used in any subtype of juvenile idiopathic arthritis (JIA). Limited studies evaluated the effect of IACI on cartilage. Our study aimed to examine the femoral cartilage thickness of patients with JIA who received IACI to the knee joint using ultrasound.

Methods
We randomly selected JIA patients who performed IACI in the knee joint. Baseline bilateral joint cartilage and tendon thicknesses were measured. The articular fluid was aspirated, and applied IACI at the same period. Six months after injection, the exact measurements were repeated. Distal femoral cartilage, quadriceps tendon, and distal and proximal patellar tendon thicknesses were compared at the baseline (before IACI) and 6 months after IACI.

Results
Thirty patients with JIA were included, and 23 (76.7%) were female. The median age was 11 years (interquartile range, 6 to 14), and the median disease duration was 3.3 years (interquartile range, 5 months to 5 years). The subtypes of JIA were oligoarticular in 25 (83.3%), polyarticular in 2 (6.7%), enthesitis-related arthritis in 2 (6.7%), and juvenile psoriatic arthritis in 1 (3.3%). Distal femoral cartilage thickness was 2.96 ± 0.79 mm at baseline and 2.85 ± 0.70 mm at 6 months after IACI (P = .35). The tendon thicknesses were similar at 6 months after baseline measurements.

Conclusions
Our findings reveal that knee IACI in patients with JIA did not significantly change cartilage and tendon thicknesses. This observation could indicate that IACIs have no detrimental effects on the cartilage and the tendons.
Epidemiology and Risk Factors for Invasive Fungal Infections in Pancreas Transplant in the Absence of Postoperative Antifungal Prophylaxis
Authors: Zachary Jessica , Chen Jeanne M , Sharfuddin Asif , Yaqub Muhammad , Lutz Andrew , Powelson John , Fridell Jonathan A , Barros Nicolas 
Published: September 2023

Abstract

Background
Invasive fungal infections (IFIs) remain a rare yet dreaded complication following pancreas transplantation. Current guidelines recommend antifungal prophylaxis in patients with 1 or more risk factors. At our center, single-dose antifungal prophylaxis is administered in the operating room but none subsequently, regardless of risk factors. Here we evaluate the 1-year incidence, outcome, and risk factors associated with IFI following pancreas transplantation.

Methods
A retrospective, single-center cohort study was conducted in patients who underwent pancreas transplantation between 1 January 2009 and 31 December 2019. Records were manually reviewed, and cases were adjudicated using consensus definitions. The 1-year cumulative incidence, mortality, and risk factors were analyzed by Kaplan-Meier method and differences between populations were assessed with Fisher test and Mann-Whitney U test.

Results
Three hundred sixty-nine recipients were included. Twelve IFIs were identified: candidiasis (8), aspergillosis (2), histoplasmosis (1), and cryptococcosis (1). Intra-abdominal infections were the most common presentation (5), followed by bloodstream infections (3), disseminated disease (2), pulmonary disease (1), and invasive fungal sinusitis (1). Median time to IFI was 64 days (interquartile range, 30–234 days). One-year cumulative incidence was 3.25% (95% confidence interval, 1.86%–5.65%). There were no significant differences between patients with or without IFI regarding type of transplant (P = .17), posttransplant dialysis (P = .3), rejection (P = .5), cytomegalovirus serostatus (P = .45), or reoperation (P = .19). For patients with IFI, the 1-year graft and patient survival rates were 58% versus 95% (P &lt; .0001) and 75% versus 98.6% (P &lt; .001), respectively.

Conclusions
Our study suggests that the use of a single-dose antifungal prophylaxis administered in the operating room but none subsequently does not result in an increased incidence of IFI following pancreas transplantation.
The silent invader: a case of intrapericardial hydatid cyst with exceptional pulmonary artery involvement
Authors: Soufiani Aida , El-Mhadi Samah , Chraibi Hamza , Agoumy Zineb , Fehri Zineb Fassi , Es-sebbani Sanae , Leghlimi Hasnaa , El Kettani Omar Ech-cherif , Lachhab Fadoua , Tribak Mohammed , Fellat Rokya , Bendagha Nesma , Moughil Said 
Published: September 2023

Abstract
A 70-year-old woman was referred to our cardiology department for the management of dyspnoea. Cardiovascular examination revealed a loud P2, with no sign of right-sided heart failure. Chest X-ray showed a convex left medium cardiac border and a double contour along the right cardiac border. Transthoracic echocardiogram revealed a cystic mass attached to the right ventricle apex. Computed tomography scan showed cyst with fluid density on the apex of the right ventricle; and a honeycomb-like aspect cyst with partial occlusion in the left pulmonary artery. Cardiac magnetic resonance imaging revealed the presence of hydatic intrapericardial cyst that compresses the right ventricular apex; associated with intraluminal left pulmonary artery cyst. Hydatic serology was positive. The patient refused surgery and was discharged on a regimen of Albendazole. She has been followed up closely with a good outcome.
Improved Symptom Change Enhances Quality of Dying in Patients With Advanced Cancer: An East Asian Cross-Cultural Study
Authors: Huang Hsien-Liang , Chen Ping-Jen , Mori Masanori , Suh Sang-Yeon , Wu Chien-Yi , Peng Jen-Kuei , Shih Chih-Yuan , Yao Chien-An , Tsai Jaw-Shiun , Chiu Tai-Yuan , Hiratsuka Yusuke , Kim Sun-Hyun , Morita Tatsuya , Yamaguchi Takashi , Tsuneto Satoru , Hui David , Cheng Shao-Yi 
Published: September 2023

Abstract

Background
Symptom burdens tend to increase for patients with cancer and their families over the disease trajectory. There is still a lack of evidence on the associations between symptom changes and the quality of dying and death. In this context, this research investigated how symptom changes influence the quality of dying and death.

Methods
This international prospective cohort study (the East Asian Collaborative Cross-Cultural Study to Elucidate the Dying Process (EASED), 2017-2019) included 22, 11, and 4 palliative care units across Japan, South Korea, and Taiwan. Eligible participants were adults (Japan and Korea, ≥18 years; Taiwan, ≥20 years) with locally advanced or metastatic cancer. Physical and psychological symptoms were assessed by physicians upon admission and within 3 days before death. Death quality was assessed using the Good Death Scale (GDS), developed in Taiwan. Univariate and multivariate regression analyses were used to identify correlations between symptom severity changes and GDS scores.

Results
Among 998 patients (542 [54.3%] men and 456 [45.7%] women; mean [SD] age = 70.1 [± 12.5] years), persistent dyspnea was associated with lower GDS scores when compared to stable dyspnea (β = −0.427, 95% CI = −0.783 to −0.071). Worsened (−1.381, −1.932 to −0.831) and persistent (−1.680, −2.701 to −0.659) delirium were also significantly associated with lower GDS scores.

Conclusions
Better quality of dying and death was associated with improved symptom control, especially for dyspnea and delirium. Integrating an outcome measurement for the quality of dying and death is important in the management of symptoms across the disease trajectory in a goal-concordant manner.
Galaxy Cruise: Deep Insights into Interacting Galaxies in the Local Universe
Authors: Tanaka Masayuki , Koike Michitaro , Naito Sei’ichiro , Shibata Junko , Usuda-Sato Kumiko , Yamaoka Hitoshi , Ando Makoto , Ito Kei , Kobayashi Umi , Kofuji Yutaro , Kuwata Atsuki , Nakano Suzuka , Shimakawa Rhythm , Tadaki Ken-ichi , Takebayashi Suguru , Tsuchiya Chie , Umemoto Tomofumi , Bottrell Connor 
Published: September 2023

Abstract
We present the first results from GALAXY CRUISE, a community (or citizen) science project based on data from the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP). The current paradigm of galaxy evolution suggests that galaxies grow hierarchically via mergers, but our observational understanding of the role of mergers is still limited. The data from HSC-SSP are ideally suited to improve our understanding with improved identifications of interacting galaxies thanks to the superb depth and image quality of HSC-SSP. We launched a community science project, GALAXY CRUISE, in 2019 and have collected over two million independent classifications of 20686 galaxies at z &lt; 0.2. We first characterize the accuracy of the participants’ classifications and demonstrate that it surpasses previous studies based on shallower imaging data. We then investigate various aspects of interacting galaxies in detail. We show that there is a clear sign of enhanced activities of super-massive black holes and star formation in interacting galaxies compared to those in isolated galaxies. The enhancement seems particularly strong for galaxies undergoing violent mergers. We also show that the mass growth rate inferred from our results is roughly consistent with the observed evolution of the stellar mass function. The second season of GALAXY CRUISE is currently underway and we conclude with future prospects. We make the morphological classification catalog used in this paper publicly available at the GALAXY CRUISE website, which will be particularly useful for machine-learning applications.
Kaon theory: 50 years later
Authors: Buras Andrzej J 
Published: September 2023

Abstract
We summarize the status of the kaon theory 50 years after the seminal paper of Kobayashi and Maskawa [Prog. Theor. Phys. 49, 652 (1973)], who pointed out that six quarks are necessary to have CP violation in the Standard Model (SM) and presented a parametrization of a 3 × 3 unitary matrix that, after the discovery of the charm quark in 1974 and the b quark in 1977, dominated the field of flavor-changing processes. One of the main goals of flavor physics since then has been the determination of the four parameters of this matrix, which we will choose here to be |Vus|, |Vcb|, and the two angles of the unitarity triangle, β and γ, with |Vus| introduced by Cabibbo in 1963. I will summarize the recent strategy for determination of these parameters without new physics (NP) infection. It is based on the conjecture of the absence of relevant NP contributions to ΔF = 2 processes that indeed can be demonstrated by a negative rapid test: the |Vcb|–γ plot. This in turn allows one to obtain SM predictions for rare K and B decays that are the most precise to date. We present strategies for the explanation of the anticipated anomaly in the ratio ε′/ε and the observed anomalies in b → sμ+μ− transitions that are consistent with our ΔF = 2 conjecture. In particular, the absence of NP in the parameter εK still allows for significant NP effects in ε′/ε and in rare kaon decays, moreover, in a correlated manner. Similarly, the absence of NP in ΔMs combined with anomalies in b → sμ+μ− transitions hints at the presence of right-handed quark currents. We also discuss how the nature of neutrinos, Dirac vs. Majorana ones, can be probed in $K\rightarrow \pi \nu \bar{\nu }$ and $B\rightarrow K(K^{*})\nu \bar{\nu }$ decays. The present status of the ΔI = 1/2 rule and ε′/ε is summarized.