bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Health-Related Quality of Life (OHQoL) in implant-supported rehabilitations: a longitudinal prospective single-center observational cohort study
Authors: Manfredini Mattia , Pellegrini Matteo , Rigoni Marta , Beretta Mario , Maiorana Carlo , Poli Pier Paolo 
Published: July 2023

Abstract

Background.To evaluate Oral Health-Related Quality of Life (OHRQoL) perceived by the patient before and after implant-prosthetic rehabilitation, to determine the physical and psychological impact that dental implants and related prosthetic rehabilitations could have in partial or edentulous patients. Finally, it was evaluated if demographic and clinical variables could influence the patient's perceived OHRQoL.
Methods.A longitudinal prospective single-center observational cohort study was conducted with patients requiring implant-prosthetic rehabilitation to evaluate OHRQoL before (T0), during (T1), and after treatment (T2) with implant-prosthetic rehabilitations. The three scores obtained at T0, T1, and T2, respectively, were compared with the variables patient's sex, age, implants placed in the aesthetic zone versus nonaesthetic zone, number of implants used in the rehabilitation, site of rehabilitation, type of definitive prosthetic rehabilitation, and type of recipient's bone.
Results. A total of 100 patients rehabilitated with 427 implants were enrolled. Statistically significant data emerged regarding the total OHRQoL score, its 7 domains, and VAS score in the 3 times considered and in relation to gender, age, aesthetics, implants number, dental arch, type of prosthesis, and type of surgery.
Conclusions. Implant-prosthetic rehabilitations significantly improve OHRQoL and aesthetics in edentulous or partially edentulous patients. The change in OHRQoL is accompanied by a marked improvement in the patient's aesthetic perception of the new smile similar in all intervals of the study.
Hemoglobin-to-platelet-count ratio is an independent predictor of cardiovascular fitness in children: Does residential air quality provide the mechanism?
Authors: Nevill Alan M , Reuter Cézane Priscila , Brand Caroline , Sehn Ana Paula , Renner Jane Dagmar Pollo , Lemes Vanilson Batista , Duncan Michael 
Published: July 2023

Abstract
Cardiorespiratory fitness (CRF) is a well-known and robust indicator of health in childhood, as well as a valuable predictor of all-cause mortality in adulthood. Understanding the associations and possible mechanisms between CRF and residential location is an important focus for public health research. A cross-sectional sample of 2250 children and adolescents, aged 6 to 17 years, were recruited from public and private schools in Santa Cruz do Sul, Rio Grande do Sul, Brazil. In addition to age, sex, and body size measurements, we also recorded hemoglobin and platelet count measurements using venous blood samples (10ml). CRF was predicted using the 6-minute run/walk test. The association between CRF and a range of possible predictors was explored using allometry. Results identified a novel and independent association between the hemoglobin-to-platelet count ratio and children’s CRF, having controlled for the usual confounding variables of age, sex, and body size. We also provide evidence of a possible mechanism for this association, having identified reduced measures of hemoglobin and increased platelet counts observed in children living in urban (vs rural) areas. These results suggest the need for more effective public health practices and policies related to the health effects of the built environment for children and adults in Brazil. We can also speculate that similar changes in health policy are necessary in congested cities worldwide, such as the introduction of ultra-low emission zones in London (introduced in April 2019).
Genomic analysis of the marine fungi Rhodotorula sphaerocarpa ETNP2018 reveals adaptation to the open ocean
Authors: Lane Dylan M. , Valentine David L. , Peng Xuefeng 
Published: July 2023

Abstract
Background
Despite a rising interest in the diversity and ecology of fungi in the ocean, there are few published genomes of fungi isolated from the ocean. The basidiomycetous yeast genus Rhodotorula are prevalent and abundant in the open ocean, and they have been isolated from a wide range of other environments. Many of these environments are nutrient poor, such as the Antarctica and the Atacama deserts, raising the question as to how Rhodotorula yeasts may have adapted their metabolic strategies to optimize survival under low nutrient conditions. In order to understand their adaptive strategies in the ocean, the genome of R. sphaerocarpa ETNP2018 was compared to that of fourteen representative Rhodotorula yeasts, isolated from a variety of environments.
Results
Rhodotorula sphaerocarpa ETNP2018, a strain isolated from the oligotrophic part of the eastern tropical North Pacific (ETNP) oxygen minimum zone (OMZ), hosts the smallest of the fifteen genomes yet encodes an average number of proteins and transcription factors. Its genome exhibits a distinct reduction in genes dedicated to Major Facilitator Superfamily transporters as well as biosynthetic enzymes. However, its core metabolic pathways are fully conserved. Our research indicates that the selective pressures of the ETNP OMZ favor a streamlined genome with reduced overall biosynthetic potential balanced by a stable set of core metabolisms and an expansion of mechanisms for nutrient acquisition.
Conclusions
In summary, this study offers novel insights into the adaptation of fungi to the oligotrophic ocean and provides valuable information for understanding the ecological roles of fungi in the ocean.
The impact of residual inflammatory risk of albumin combined with C-reactive protein on long-term mortality in cardiovascular disease patients
Authors: Zhu Houyong , Wang Hanxin , Zhu Xinyu , Xu Xiaoqun , Yang Chao , Liu Xiao , Chen Qilan , Fang Xiaojiang , Gao Beibei , Ping Yan , Tong Guoxin , Xie Jianchang , Jin Xiangbo , Guan Yihong , Zhao Guoying , Chen Tielong , Huang Jinyu 
Published: July 2023

Abstract
Purpose
The secondary prevention strategy for cardiovascular disease (CVD) does not include anti-inflammatory treatment, which may lead to some patients being in a high inflammatory state for a long time. The aim of this study was to assess the association between the residual inflammatory risk based on Glasgow Outcome Score (GPS) and long-term mortality in patients with CVD.
Methods
This study included 3833 patients (≥ 20 years old) with CVD in the National Health and Nutrition Survey from 1999 to 2010. The death result is determined by the correlation with the national death index on December 31, 2019. GPS consists of serum C-reactive protein and albumin. The main outcome was all-cause death, including cardiac death and non-cardiac death. The Cox proportional hazards adjusted for demographic factors and traditional cardiovascular risk factors were used to test the impact of GPS level on mortality. The sensitivity analysis included components of CVD, heart failure, coronary heart disease, angina, heart attack, and stroke.
Results
Among 3833 CVD patients with a median follow-up of 9.6 years, 2431 all-cause deaths, 822 cardiac deaths, and 1609 non-cardiac deaths were recorded. After full model adjustment, compared with the GPS (0) group, the risk ratio (HR) of all-cause death for GPS (1) and GPS (2) were 1.667 (95% confidence interval (CI), 1.490–1.865) and 2.835 (95% CI, 2.077–3.869), respectively (P for trend < 0.001). Compared with the GPS (0) group, the HR of cardiac death for GPS (1) and GPS (2) were 1.693 (95% CI, 1.395–2.053) and 2.268 (95% CI, 1.264–4.070), respectively (P for trend < 0.001). Compared with the GPS (0) group, the HR of non-cardiac death for GPS (1) and GPS (2) were 1.656 (95% CI, 1.443–1.901) and 3.136 (95% CI, 2.171–4.530), respectively (P for trend < 0.001). The results of the sensitivity analysis were almost consistent with the overall cohort.
Conclusions
Using the US national database, and adjusting for a large number of potential confounders through flexible modeling, we found that residual inflammatory risk based on GPS was strongly associated with a increased risk of death in patients with CVD and that the higher GPS level was associated with an increased risk of death, and this score, which consists of readily available biomarkers, may in the future be used for risk stratification and potentially for improving patient outcomes.
Short and decadal impacts of seafloor physical perturbation on the abundances of Lebensspuren ‘traces of life’ in the Peru Basin manganese nodule province.
Authors: Purser Autun , Vornsand Ina , Boehringer Lilian , Thomsen Laurenz 
Published: July 2023

Abstract
Interest in deep sea mining for polymetallic nodules as an alternative source to onshore mines for various high technology metals has risen in recent years, as demands and costs have increased. The need for studies to assess its short- and long-term consequences on polymetallic nodule ecosystems is therefore also increasingly prescient. Recent image-based expedition studies have described the temporal impacts on epi-/megafauna seafloor communities across these ecosystems at particular points in time. However, these studies have failed to capture information on large infauna within the sediments or give information on potential transient and temporally limited users of these areas, such as mobile surface deposit feeders or fauna responding to bloom events or food fall depositions. This study uses data from the Peru Basin polymetallic nodule province where the seafloor was disturbed in 1989 and 2015 to simulate mining disturbance. To try and address the shortfall on transient fauna and infauna use of these various disturbed and undisturbed regions of nodule-rich seafloor, images collected 6 months after the 2015 disturbance event were inspected and all Lebensspuren, ‘traces of life’ were characterized by type and logged, along with whether they occurred on undisturbed seafloor, or regions disturbed in 1989 or 2015. The results show that traces of surface/ocean interface use of disturbed areas by infauna and mobile fauna are at least 50% lower, even 26 years after disturbance, with many trace categories not present in even low numbers on disturbed seafloor areas.
Safety assessments and clinical features of PARP inhibitors from real-world data of Japanese patients with ovarian cancer
Authors: Uekusa Ryosuke , Yokoi Akira , Watanabe Eri , Yoshida Kosuke , Yoshihara Masato , Tamauchi Satoshi , Shimizu Yusuke , Ikeda Yoshiki , Yoshikawa Nobuhisa , Niimi Kaoru , Suzuki Shiro , Kajiyama Hiroaki 
Published: July 2023

Abstract
Background
Poly (ADP-ribose) polymerase (PARP) inhibitors, such as olaparib and niraparib, have been increasingly used in ovarian cancer treatment. However, the real-world safety data of these drugs in Japanese patients and the predictability of treatment interruptions are limited.
Methods
This retrospective study included 181 patients with ovarian cancer who received olaparib or niraparib at two independent hospitals in Japan between May 2018 and December 2022. Clinical information and blood sampling data were collected. Patient characteristics, treatment history, and hematological data trends were compared, and the predictability of treatment interruptions based on blood sampling data was examined.
Results
Regarding patient backgrounds, the olaparib group had higher proportions of patients with serous carcinoma, BRCA positivity, homologous recombination deficiency, and those receiving maintenance therapy after recurrence treatment than the niraparib group. Regarding toxicity properties, the most common reasons for discontinuation in the olaparib group were anemia, fatigue, and nausea, while discontinuation was primarily due to thrombocytopenia in the niraparib group. Thrombocytopenia caused by niraparib treatment occurred earlier than anemia caused by olaparib treatment. Patients with a low body mass index or who had undergone several previous treatment regimens were more likely to discontinue treatment due to adverse effects within the first 3 months. Although we analyzed blood collection data, predicting treatment interruptions due to blood toxicity using blood data was challenging.
Conclusions
In this study, we revealed the characteristics of patients and the timing of interruptions for each drug, highlighting the importance of carefully managing adverse effects, particularly during the early treatment stages.
The role of antipsychotics and other drugs on the development and progression of Neuroleptic Malignant Syndrome
Authors: Kyotani Yoji , Zhao Jing , Nakahira Kiichi , Yoshizumi Masanori 
Published: July 2023

Abstract
Neuroleptic malignant syndrome (NMS) is a rare but serious and sometimes fatal complication in patients taking antipsychotic drugs, and its underlying mechanism still remains unclear. The pharmacotherapy for psychotic disorders is complicated and often involves a combination of two or more drugs, including drugs other than antipsychotics. In the present study, we used the Japanese Adverse Drug Event Report (JADER) database to broadly investigate the drugs associated with NMS, following their related pathways, as well as the drug-drug interactions (DDIs) in NMS. All analyses were performed using data from the JADER database from April 2004 to May 2022. Single-drug signals were evaluated using the reporting odds ratio (ROR) and proportional reporting ratio (PRR), and drug pathways were investigated using the Kyoto Encyclopedia of Genes and Genomes (KEGG). DDIs were evaluated using the Ω shrinkage measure and Chi-square statistics models. All drugs associated with 20 or more NMS cases in the JADER database exhibited signals for NMS, including non-antipsychotics. Pathways associated with the drugs included the dopaminergic or serotonergic synapses related to antipsychotics. DDIs leading to NMS were confirmed for several drug combinations exhibiting single-drug signals. This study confirmed the significant association of various drugs, including non-psychotics, with NMS and suggested that various pathways related to these drugs may be involved in the progression of NMS. In addition, several combinations of these drugs were found to interact (DDI), increasing the risk of NMS, which suggests that appropriate caution should be taken when administering these drugs.
Assessment of Hypoxemia among Young Adults with Sickle Cell Anaemia in Steady State: A cross‑sectional study
Authors: Asafa Muritala A. , Ahmed Ibrahim O. , Afolabi Michael S. , Bolarinwa Rahman A. , Ogunlade Oluwadare 
Published: July 2023

Abstract
Objectives
Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis which can cause tissue ischaemia that leads to an end organ damage. The hallmark of SCA is chronic anaemia and recurrent vaso-occlusive crisis. The aim of this study is to compare the oxygen saturation of sickle cell anaemic individuals with the normal haemoglobin type (Hb AA) control and also to determine the prevalence of hypoxemia among SCA.
Results
Two-hundred and twenty-two (136 Hb SS and 86 Hb AA) participated in the study. The mean ± SD of age (years), oxygen saturation (%) and pulse rate (bpm) of participants with sickle cell anaemia and Hb AA control were 21.85 ± 3.04 and 22.14 ± 3.18 (t = 0.701, p = 0.436), 95.21 ± 3.02 and 98.07 ± 0.81 (t=-8.598, p < 0.0001) and 77.10 ± 9.28 and 73.16 ± 8.52 (t = 3.173, p = 0.002) respectively. The prevalence of hypoxemia among SCA participants was 47.1%. Prevalence of hypoxemia in males with SCA was 60.9% while 39.1% of the females had hypoxemia.
Surviving a tiger attack at a Japanese safari park: A case report
Authors: Fujii Kouichi , Kikuchi Jin , Uchida Masatoshi , Machida Masanari , Tsuchiya Midori , Hayashi Kentaro , Maekawa Nana , Houzimi Hajime , Honda Arata , Wake Koji 
Published: July 2023

Abstract
Background:Big cat bites are highly lethal due to the enormous bite force of these animals. This article reviews the morphology of these types of injuries and key points of management through a survival case at a Japanese safari park.
Case presentation: We report the case of a 26-year-old female keeper who was attacked by a tiger. She was quickly transported to our university hospital by ambulance helicopter. The keeper was severely bitten on the head and face and had wounds all over her body. Craniofacial repair was performed by emergency surgery. She suffered mild facial nerve paralysis and trismus because of being bitten by the tiger, and is currently recovering.
Conclusions:A multidisciplinary approach of the severe tiger bites successfully treated a young woman cosmetically and mentally. Animal farms and zoos that keep tigers should take strict measures to avoid direct confrontation with tigers.
Surgical and radiological perspectives for the Spinal Accessory Nerve passing through a fenestrated Internal Jugular Vein: case series and literature review
Authors: Guarino Pierre , Tesauro Paolo , Mattioli Francesco , Caporale Claudio Donadio , Presutti Livio , Giordano Leone 
Published: July 2023

Abstract
Rationale
The preservation of the spinal accessory nerve (SAN) represents a key goal in head and neck oncologic surgery during selective neck dissection. This study aims to illustrate the anatomical variants of the XI cranial nerve, delving into the relationship between the spinal nerve and the internal jugular vein (IJV), as well as the surgical implications.
Materials and Methods
Two cases of patients who underwent oncologic surgery with neck dissection are described. Both cases found the SAN passing through the fenestration of the internal jugular vein.
An independent literature review was conducted alongside the case report using the Medline and PubMed databases. Articles were selected by searching for the following key words: "spinal accessory nerve," "cranial nerve XI," "shoulder syndrome," "fenestrated jugular vein," "anatomy," "surgical anatomy," and "anatomical variant."
This review aims to describe: the incidence of the anatomical variants of the accessory nerve, its resulting surgical implications, the imaging techniques useful in their identification and the underlying embryology.
Results
According to the literature, in the majority of cases (67–96%), the SAN traces a lateral course to the IJV. Less frequently, the XI cranial nerve courses medial to the IJV. A rarer anatomical variant, as described in the case report of this article, sees the nerve crossing through the fenestration of the vein (incidence: 0.48–3.3%). One report also indicates the nerve splitting around the internal jugular vein.
Conclusions
Anatomic variants of the spinal nerve are less frequent but their knowledge is of paramount importance to the head and neck surgeon in order to avoid iatrogenic damage to the SAN and the IJV.
Possible Influence of Psychological Distance to Women’s Intrasexual Mating Competition
Authors: Widman David R. , Fisher Maryanne L. , Burch Rebecca L. 
Published: July 2023

Abstract
Purpose
Researchers have studied intrasexual competition by priming the competition using a variety of techniques, including manipulated sex ratios and vignettes implying a competition either for resources critical for obtaining mates or directly for mates. When priming intrasexual competition, changes in the dependent variable of interest are generally taken as prima facie evidence of intrasexual competition; few researchers have tried to independently assess intrasexual competition.
Methods
The studies presented here replicate and extend one such state measure of intrasexual competition using words taken from the Positive and Negative Affect Schedule (PANAS) with additional competition words (PANAS-Short Form with an added competitive subscale). The first study used a vignette manipulation and the second used a sex ratio manipulation. Participants then responded to the modified PANAS, the Intrasexual Competition Scale (ICS) and the Intrasexual Rivalry Scale (IRS).
Results
Results indicated that neither manipulation resulted in differences on the ICS or IRS. There were differences on the negative and competitive subscales of the modified PANAS, but only for the vignettes manipulation; sex ratio did not result in effects on any of the subscales. These results suggest that different intrasexual competition primes may not be accessible by a single measure.
Conclusion
One explanation may be that the vignettes specify a target while the unbalanced sex ratios do not, which could create a difference in the psychological distance to a target. Studies in non-human animals have shown that distance and time to reinforcement affects the types of responses and conditioned responses that the reinforcer can support (e.g., behavior systems, Timberlake & Lucas, 1989), which we apply to this work.
Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction
Authors: Nakamura Takuya , Watanabe Makoto , Sugiura Junichi , Kyodo Atsushi , Nobuta Saki , Nogi Kazutaka , Nakada Yasuki , Ishihara Satomi , Hashimoto Yukihiro , Nakagawa Hitoshi , Ueda Tomoya , Seno Ayako , Nishida Taku , Onoue Kenji 
Published: July 2023

Abstract
This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 877 patients who underwent emergency PCI for AMI were examined. AKI was defined as serum creatinine (SCr) ≥ 0.3 mg/dL or ≥ 50% from baseline within 48 h after PCI. Persistent AKI was defined as residual impairment of SCr ≥ 0.3 mg/dL or ≥ 50% from baseline 1 month after the procedure. The primary outcome was the composite endpoints of death, myocardial infarction, hospitalization for heart failure, stroke, and dialysis. AKI and persistent AKI were observed in 82 (9.4%) and 25 (2.9%) patients, respectively. Multivariate Cox proportional hazards analysis demonstrated that persistent AKI, but not transient AKI, was an independent predictor of primary outcome (hazard ratio, 4.99; 95% confidence interval, 2.30–10.8; P < 0.001). Age > 75 years, left ventricular ejection fraction < 40%, and a high maximum creatinine phosphokinase MB level were independently associated with persistent AKI. Persistent AKI was independently associated with worse clinical outcomes in patients who underwent emergency PCI for AMI. Advanced age, poor cardiac function, and large myocardial necrosis were predictors of persistent AKI.