bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEXUAL-DIMORPHISM IN HUMAN IMMUNE SYSTEM AGING
Authors: Ucar Duygu , Kuchel George , Banchereau Jacques , Ravichandran Sathyabaarathi , Karakaslar Onur , Diaz Fernando Erra , Marquez Eladio , Marches Radu 
Published: December 2022

Abstract
Differences in immune function and responses contribute to health- and life-span disparities between sexes. However, the role of sex in immune system aging is not well understood. Here, we characterize peripheral blood mononuclear cells from 172 healthy adults 22–93 years of age using ATAC-seq, RNA-seq and flow cytometry. These data reveal a shared epigenomic signature of aging including declining naïve T cells and increasing monocyte and cytotoxic cell functions. These changes are greater in magnitude in men and accompanied by a male-specific decline in B-cell-specific loci. Interestingly, genomic differences between sexes increase after age 65, with men having higher innate and pro-inflammatory activity and lower adaptive activity. In a separate cohort (n=39) we studied how older adults respond to two available pneumococcal vaccines: T-dependent Prevnar and T-independent Pneumovax. How older adults respond to these vaccines at the molecular and cellular level, and whether there are pre-vaccination predictors for vaccine responsiveness, is poorly understood. To address this, we characterized serum antibody responses and peripheral blood leukocyte composition using flow cytometry and transcriptional profiles using RNA-seq, in healthy older adults before and after vaccination. The vaccines induced comparable serological responses and increases in the number of ICOS+ T follicular helper cells. A shared plasmablast transcriptional signature (IGHG2, IGHA1, IGHA2) was induced by both vaccines ten days after vaccination, which is distinct from influenza vaccine responses. Importantly, the pre-vaccination (baseline) ratio of Th1/Th17 cells predicted responsiveness to Prevnar but not to Pneumovax. Interestingly, women had higher levels of Th1/Th17; and responded stronger to Prevnar compared to men. This study uncovered how older adults respond to different pneumococcal vaccines and demonstrated the significance of considering biological sex and the immune cell composition for precision vaccinology.
TOOLS TO SUPPORT NEEDS ASSESSMENTS ON DEMENTIA, COGNITIVE HEALTH, AND CAREGIVING
Authors: Shean John , Sands Talyah , Shah Priya , Donnellan Kelsey 
Published: December 2022

Abstract
Dementia, cognitive health, and caregiving are not always included in community health needs assessments, leading to their absence in public health improvement and strategic plans, and subsequent lack of action and funding to address these needs. In response, the Alzheimer’s Association and the Association of State and Territorial Health Officials published the Needs Assessment Toolkit for Dementia, Cognitive Health, and Caregiving. Designed for state, local, and territorial public health and aging officials, this toolkit helps communities identify unmet needs of older adults, scale up existing community strengths, and promote healthy aging. The toolkit embeds health equity as a cornerstone to assessing community health. It offers approaches to operationalize equity in the assessment process by including wide representation of people from different racial and ethnic backgrounds, geographic locations, and levels of socioeconomic status and educational attainment. The toolkit’s five steps are modular in design and allow jurisdictions to enter the process at any stage. It considers alignment with jurisdiction-wide plans including Alzheimer’s plans, health improvement plans, aging plans, and the Healthy Brain Initiative Road Map, helping public health agencies advance attention to Alzheimer’s through their networks. Developed through an iterative process, expert input from public health and aging practitioners guided the development and organization. Over 1,600 comments were reconciled to ensure usability among stakeholders, elevate equity to an essential component throughout the assessment process, and add value to allied strategic plans. This presentation complements Learn, Plan, Do: Public Health Planning to Address Dementia and Caregiving, abstract ID 1229181.
PEDAGOGY OF AGING: A JOURNEY TOWARD AUTHENTICITY AND WHOLENESS
Authors: Donorfio Laura 
Published: December 2022

Abstract
Innovation in gerontological education has been a driving catalyst since the beginning of my career over 30 years ago. While sometimes seen as a curse, this catalyst has shaped my teaching pedagogy in unimaginable ways. Examples include field trips with 40+ students, developing an aging toolbox for students to make the material more concrete, creating a new interactive television teaching platform over multiple university campuses, developing experiential curriculum and an undergraduate minor in aging, and proudly, developing AGHE’s first teaching institute now in its 11th year. Unexpectedly, at this stage of my career, I have become very aware that my teaching about aging has intersected with my personal aging, shaping my personal pedagogy in profound ways--increased empathy, sensitivity, and social awareness. I am living the subject matter I thought I intimately knew. I am the other. Has my teaching been inauthentic? Hypocritical? Ageist? Please join me for a healthy discussion on how this insight can be leveraged to teach the next generation of aging scholars.
CUMULATIVE (DIS)ADVANTAGE IN COGNITIVE HEALTH: RURAL/URBAN RESIDENCY, HUKOU, AND COGNITIVE AGING IN OLDER CHINESE
Authors: Zhang Yuan , Song Qian , Chen Jen-Hao 
Published: December 2022

Abstract
Urban residency benefits cognition in later life. In China, the household registration system (hukou) creates another place-based advantage/disadvantage for cognitive aging. We exam the interplay of rural/urban residence and hukou across the life-course in creating cumulative advantage/disadvantage in cognitive aging trajectories using longitudinal data from the 2011-2018 China Health and Retirement Longitudinal Study and its Life History Survey. Results from linear mixed effect models show that always urban dwellers with urban hukou exhibited the highest level of cognitive function and the slowest decline, and the always rural dwellers with rural hukou had the worst cognitive function and experienced a faster decline. Rural-to-urban shifts had better cognitive health than always rural dwellers, but the advantages depend on urban hukou attainment and specific mechanisms. This research suggests cumulative advantage/disadvantage in cognitive aging by residence and hukou throughout life and demonstrates that institutional discrimination and exclusionary policy may create inequality in aging processes.
OVERVIEW AND EVIDENCE-BASE FOR PREVENTING LOSS OF INDEPENDENCE THROUGH EXERCISE (PLIÉ)
Authors: Barnes Deborah , Chesney Margaret , Chao Linda , Mehling Wolf 
Published: December 2022

Abstract
PLIÉ was initially developed and tested in the adult day setting. Caregivers reported qualitative improvements in PLWD in psychological, physical, cognitive, and social domains that were supported by class video-recordings. Paired PLIÉ was adapted for the community setting and expanded to include dyads of PLWD and care partners (CPs) who participated in group classes together. PLWD reported significant improvements in self-rated quality of life, and CPs reported psychological, physical, cognitive, and social benefits for PLWD as well as themselves. We then adapted PLIÉ for people with mild cognitive impairment (MCI) and found that it significantly increased default mode network connectivity on resting-state functional MRI scans, while improving quantitative measures of cognitive function, social isolation, physical performance and self-regulation. We also implemented PLIÉ in a VA skilled nursing facility, where a post-implementation evaluation determined that residents, staff and family members all reported psychological, physical, cognitive and social benefits.
MOVING TOGETHER ONLINE FOR PEOPLE LIVING WITH MILD COGNITIVE IMPAIRMENT/DEMENTIA AND CARE PARTNERS
Authors: Nicosia Francesca , Lee Amanda , Chesney Margaret , Lee Jennifer , Benjamin Cynthia , Mehling Wolf , Sudore Rebecca , Barnes Deborah 
Published: December 2022

Abstract
This study used Human Centered Design methods to develop a digital platform tailored for PLWD and test an online version of PLIÉ, called Moving Together. We assessed feasibility and satisfaction of a 12-week online program using completion rates, attendance, and evaluation surveys. 39 people (18 PLWD, 7 MCI, 14 CP) attended 75% classes; 96% rated classes as excellent or good; and 88% were highly likely to recommend Moving Together. Participants reported benefits in social connection (“camaraderie,” “like a family”), emotional well-being (“happier,” “less stressed”), physical function (“stronger,” “more range-of-motion”), cognitive function (“more focus,” “learning new things”), and present-centered body awareness (“more conscious of breathing patterns”). PLWD/MCI experienced improved self-concept (“less immediate shame and more confidence”); and Care Partners reported improved caregiving efficacy (“greater purpose,” “more comfortable”). Online delivery of Moving Together is feasible for people with dementia or mild cognitive impairment and care partners.
DESIGN AND DEVELOPMENT OF MHEALTH FOR DEMENTIA: CURRENT AND FUTURE DIRECTIONS
Authors: Sadarangani Tina , Holden Richard 
Published: December 2022

Abstract
Alzheimer’s disease and related dementias (ADRD) represent an increasingly prevalent group of neurodegenerative chronic diseases for which there is no cure. Progressive functional and cognitive decline in individuals with ADRD places considerable demands on those involved in their care, including clinicians and care partners. Mobile health technology has the potential to support people living with dementia and their care team members, as well as potentially prevent the onset of dementia symptoms. In this symposium we first examine best practices in mhealth application development for dementia care based on applications developed for other chronic illnesses. We then examine mhealth applications being developed in three different NIH-funded studies that address the needs of clinicians, care partners, adult day centers involved in the care of people with dementia, as well as an application for people with mild cognitive impairment. The Aliviado Dementia Care app is a resource that enables clinicians to access best practices for managing behavioral and psychological symptoms of dementia at the point of service. CareMOBI streamlines communication between care partners, adult day centers, and primary care providers, allowing care team members to track and exchange information relevant to dementia care and identify emerging clinical problems. Finally, Spanish-language information and culturally relevant motivational messages to promote physical activity and delay progression to ADRD among those with mild cognitive impairment within the Tiempos Juntos intervention are presented. Our discussion summarizes the current and future direction of mhealth application development in ADRD, and key learnings from presenters’ work.
CAREMOBI: AN APP CONNECTING CAREGIVERS, ADULT DAY CENTERS, AND HEALTHCARE PROVIDERS CARING FOR PEOPLE WITH DEMENTIA
Authors: Sadarangani Tina , Boafo Jonelle , Zhong Jie 
Published: December 2022

Abstract
Fragmented communication between care partners, health care providers, and adult day centers around the needs of persons living with dementia (PLWD) contributes to avoidable health care utilization. CareMOBI, is a user-centered mobile application that streamlines information exchange around datapoints relevant to the care of PLWD. CareMOBI facilitates team-based communication around emerging clinical problems by uniquely integrating the knowledge and day-to-day observations of adult day center staff and care partners. We present a stakeholder engaged approach to iteratively designing and validating an initial prototype. Through interviews and focus groups with adult day center staff (n=31), primary care providers (n=22), and family caregivers (n=13) we identified barriers to communication across settings. We then visually mapped the domains of a future app which we subsequently validated and refined with end-users (n=25). We present our current prototype which synthesizes these findings and addresses key barriers to information exchange across community settings serving PLWD.
THE ROLE OF MULTIDOMAIN IDENTITY AND SOCIAL BACKGROUND FACTORS FOR AGING OUTCOMES
Authors: Drewelies Johanna , Duezel Sandra , Demuth Ilja , Steinhagen-Thiessen Elisabeth , Lindenberger Ulman , Goebel Jan , Stadler Gertraud , Gerstorf Denis 
Published: December 2022

Abstract
Domains of social privilege are predictive of a number of key aging outcomes, such as physical and cognitive functioning. However, less is known about the dynamic interplay of - related but distinct- domains of privilege and how they are associated with cognitive and physical functioning. In the following project, we aim to close this gap by examining the role of multidomain identity and social background factors for initial levels and subsequent changes in psychological, cognitive and physical functioning. Specifically, we identified predefined social privileges within the Berlin Aging Study II (BASE-II) sample (e.g., gender identity, gender conformity, sexuality, education, socioeconomic status, religion) and related these categories, interactively, to markers of physical health (multimorbidity), perceptual speed (digit symbol), and psychosocial functioning (loneliness). Results highlight the dynamic interplay (i.e., intersectionalism) of multidomain identity and social background factors with aging related outcomes across a number of key domains.
DIVERSITY, DISCOVERY, AND AGING REIMAGINED: A CHAT WITH NIA SENIOR LEADERSHIP
Authors: Kelley Amy , Kelley Amy 
Published: December 2022

Abstract
The National Institute on Aging (NIA) at the National Institutes of Health, Department of Health and Human Services, is the federally designated lead agency on aging research and supports research to understand the nature of aging and to extend the healthy, active years of life. In the last six years, NIA has experienced a tripling of its budget. In keeping with NIA’s scientific mission, funding includes significant investments in Alzheimer’s disease (AD) and AD-related dementias research, as well as in non-AD research. This symposium will provide a forum for exploration of the implications of the NIA budget for the general research community. NIA’s senior staff will discuss research priorities and programs supported by the Institute. A question-and-answer session will follow these remarks on current funding and future priorities and research directions of NIA.
USING MULTIDIMENSIONAL SCALING IN COMBINATION WITH CLUSTER ANALYSIS TO STRUCTURE THE PELI-D QUESTIONNAIRE
Authors: Bergmann Johannes-Michael , Stacke Tobias , Purwins Daniel , Manietta Christina , Rommerskirch-Manietta Mike , Stroebel Armin , Roes Martina 
Published: December 2022

Abstract

Background
One way to contribute person-centered care is the use of a preference-based approach. In our project PELI-D the original PELI USA-version for Nursing Homes was (1) translated into German (2) and structured to explore construct validity of the instrument. Objective and Method: The PELI-D instrument (72-items) is used to illustrate how structuring procedures can be used for concept analysis. The approach allows to analyze the instrument from the perspective of the professional caregivers and to identify theoretical relations in further steps, which can be finally validated. For this purpose, the data of 58 professional nurses are analyzed.

Results
We computed a three-dimensional concept map of preferences enabled us in a second step to identify an appropriate cluster solution. The five-cluster solution, which explained 79 percent of the total variance, seemed to offer the best balance between statistical analysis and detailed categorisation through qualitative interpretation.
USING MULTICORRESPONDENCE ANALYSES AND CLUSTER ANALYSIS TO CONSTRUCT TYPES OF CARE ARRANGEMENTS
Authors: Dreyer Jan , Bergmann Johannes-Michael , Koehler Kerstin , Hochgraeber Iris , Pinkert Christiane , Roes Martina , Holle Bernhard 
Published: December 2022

Abstract
Most persons with dementia live at home and are cared for by family carers and professional carers. Together, they form care arrangements to address the needs of persons with dementia. The aim of this study is to (1) uncover the underlying structures of home-based care arrangements for persons living with dementia, (2) construct types of these care arrangements, and (3) compare these types with regard to their stability. In this secondary analysis, data from 320 care arrangements for persons with dementia are analysed using multiple correspondence analysis and hierarchical cluster analysis. The multiple correspondence analysis identified 27 axis that explained the entire variance between all care arrangements. The subsequent cluster analysis identified four types of care arrangements. Two types included spouse-centred care arrangements, and two types included child-centred care arrangements at different phases of the dementia and care trajectory. The types differ with regard to their stability.
EXPLORING STRATEGIES FOR IMPROVED COORDINATION AND INNOVATION IN TRANSPORTATION FOR OLDER PEOPLE
Authors: Silverstein Nina , Jansen Taylor , Bayne Alycia 
Published: December 2022

Abstract
Communities across the nation have outgrown their capacities to meet the transportation needs of older people. While a struggle in the past, for many communities it now is a crisis given an increase in older people with impairments in critical driving skills that lead to driving cessation and/or limitations that preclude them from successfully navigating public transit. It is time for new strategies and innovations to meet these growing challenges. Jansen will describe a pilot study of a regional transit authority’s use of customized software with four Councils on Aging to increase riders’ trips and destinations, improve efficiencies in reporting and dispatching, and increase shared rides across the communities. Gleason will present results of a qualitative study of paratransit managers across the U.S. and their attempts to innovate and adapt to evolving market expectations spurred on by the emergence of transportation network companies (TNC) like Uber and Lyft. Schwartz describes a mixed-methods study of Project TRIP, a rural transportation program designed to increase access to healthcare and other locations for low income and vulnerable populations in rural eastern North Carolina. Lynott introduces AARPs RideSheet, an open-source ride scheduling software application designed for small, demand-responsive transportation providers that incorporates a transactional data specification (TDS) enabling two or more providers to interoperate more efficiently, improving service for their clients. Bayne concludes as discussant bringing in her own work with the CDC on barriers and facilitators to ride sharing and reflecting on the themes presented. Transportation and Aging and Qualitative Research IGs collaboration.
GERONTOLOGICAL BIOSTATISTICS AS THE FOUNDATION OF INTERDISCIPLINARY DATA SCIENCE IN AGING
Authors: Travison Thomas 
Published: December 2022

Abstract
Explosive growth in computing power has increased by orders of magnitude the complexity of data structures and the number of analyses that may be performed per unit time. Contemporary gerontology utilizes diverse data ranging from continuous longitudinal assessments (e.g. motion capture) to complex single-timepoint assessments (e.g. bioimages) to systems-level administrative descriptions of the healthcare delivery environment. Paradoxically, this abundance of resources presents a considerable challenge, as the availability of information threatens to overwhelm mechanistic models of aging supportive of intervention development. To inform precision medicine, gerontological biostatistics therefore embraces the opportunity of collaborating with allied quantitative disciplines to bolster the coherence, reproducibility, and generalizability of findings. This presentation will demonstrate the salient advantages of such interdisciplinary collaborations using the example of design and analysis of an intensely longitudinal study of wearable and environmental sensors, conducted with teams in exercise science and architectural design.
CHRONIC PHYSICAL HEALTH CONDITIONS, DEPRESSIVE SYMPTOMS, AND SELF-RATED HEALTH IN GRANDMOTHERS
Authors: Henrich Christina , Musil Carol , Zausniewski Jaclene , Burant Christopher , Tracy Elizabeth , Jeanblanc Alexandra 
Published: December 2022

Abstract
Grandmothers often participate in caregiving to grandchildren, ranging from informal caregiving to having responsibility for raising grandchildren, but health problems may affect their ability to do so. To better understand potential health problems in grandmother caregivers, this secondary analysis examined 1) longitudinal relationships between chronic physical health conditions, depressive symptoms, and self-rated health with race, age, & marital status, and 2) causal ordering of depressive symptoms and self-rated health, controlling for baseline race, age, marital status, and chronic conditions of 328 Ohio grandmothers across 3 time points over 2 years. The study was guided using Lenz’s Theory of Unpleasant Symptoms. Measures included chronic physical health conditions (modified Charlson), depressive symptoms (CES-D), self-rated health (SF-36), and demographic variables of race (white/nonwhite), age, and marital status (married-partnered/not married). Analyses included correlations and structural equation modeling. Pearson product moment correlations indicated significant relationships (ranging from 0.26 to 0.56) between chronic conditions, depressive symptoms and self-rated health at all three time points. Next, a bivariate autoregressive model was tested using structural equation modeling. The data fit the model well. The goodness of fit results included: Chi square=55.39, TLI=0.94, CFI=0.97, and RMSEA=0.07. Results indicated consistency of depressive symptoms and self-rated health over time, and these were affected by chronic conditions; the causal order indicated that self-rated health impacts depressive symptoms. This study contributes new knowledge about the relationships and causal sequence of self-rated health and depressive symptoms. Implications on practice and research are discussed.