bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphoproteomics implicates glutamatergic and dopaminergic signalling in the antidepressant-like properties of the iron chelator deferiprone
Authors: Uzungil Volkan , Luza Sandra , Opazo Carlos M , Mees Isaline , Li Shanshan , Ang Ching-Seng , Williamson Nicholas A , Bush Ashley I , Hannan Anthony J , Renoir Thibault 
Published: September 2023

AbstractCurrent antidepressants have limitations due to insufficient efficacy and delay before improvement in symptoms. Polymorphisms of the serotonin transporter (5-HTT) gene have been linked to depression (when combined with stressful life events) and to altered response to selective serotonergic reuptake inhibitors. We have previously revealed the antidepressant-like properties of the iron chelator deferiprone in the 5-HTT knock-out (KO) mouse model of depression. Furthermore, deferiprone was found to alter neural activity in the prefrontal cortex of both wild-type (WT) and 5-HTT KO mice. In the current study, we examined the molecular effects of acute deferiprone treatment in the prefrontal cortex of both genotypes via phosphoproteomics. In WT mice treated with deferiprone, there were 22 differentially expressed phosphosites, with gene ontology analysis implicating cytoskeletal proteins. In 5-HTT KO mice treated with deferiprone, we found 33 differentially expressed phosphosites. Gene ontology analyses revealed phosphoproteins that were predominantly involved in synaptic and glutamatergic signalling. In a drug naive cohort, the analysis revealed 21 differentially expressed phosphosites in 5-HTT KO compared to WT mice. We confirmed the deferiprone-induced increase in Tyrosine hydroxylase serine 40 residue phosphorylation (pTH-Ser40) (initially revealed in our phosphoproteomics study) by western blots, with deferiprone increasing pTH-Ser40 expression in WT and 5-HTT KO mice. As glutamatergic and synaptic signalling are dysfunctional in 5-HTT KO mice (and are the target of fast-acting antidepressant drugs such as ketamine), these molecular effects may underpin deferiprone’s antidepressant-like properties. Furthermore, dopaminergic signalling may also be involved in deferiprone’s antidepressant-like properties.
The 18th FINA world masters championships and destination loyalty
Authors: Kim Euisoo , Kim Sukkyu , Jeong Yunduk 
Published: September 2023

PurposeBased on a stimulus–organism–response theory, the purpose of this study is to empirically examine structural equation model linking personal involvement, positive emotions, tourist satisfaction and destination loyalty among sport tourists to a mega sport event. Moreover, moderating effects of place attachment on the relation between the aforementioned variables were investigated.Design/methodology/approachThe validities and reliabilities of the measures were investigated through confirmatory factor analysis, Cronbach's alpha and correlation analysis. A structural equation modelling with maximum likelihood estimation was tested to analyze the relationships among the research variables using 383 participants.FindingsThe results revealed positive associations among stimulus (personal involvement), organism (positive emotions) and response (tourist satisfaction and destination loyalty). Moreover, the authors found moderating effect of place attachment on the relationships between personal involvement and positive emotions, personal involvement and tourist satisfaction and tourist satisfaction and destination loyalty.Research limitations/implicationsThis study holds the potential to aid destination managers in acquiring a more profound comprehension of how personal involvement contributes to elicit positive emotions, keep tourists satisfied and build destination loyalty as well as demonstrating the moderating roles of place attachment. However, generalizing the findings to alternative contexts presents a formidable challenge. Enhancing the applicability of these findings could be achieved through prospective research endeavors that explore visitors in diverse cities spanning various continents.Originality/valueThe study contributed to the literature by providing empirical evidence that personal involvement evokes positive emotions while also plays significant role in improving satisfaction and loyalty. Given the importance of experiences in sport tourism, this study also confirmed the role of positive emotions on tourist satisfaction and destination loyalty. Additionally, this study examined the moderating effect of place attachment, which has not been investigated in sport tourism context.
The effect of perceived quality and customer engagement on the loyalty of users of Spanish fitness centres
Authors: Gálvez-Ruiz Pablo , Calabuig Ferran , Grimaldi-Puyana Moisés , González-Serrano María Huertas , García-Fernández Jerónimo 
Published: September 2023

PurposeThe purpose of this paper is to analyse the influence of perceived quality and customer engagement on perceived value and satisfaction in a model to evaluate loyalty in users of fitness centres.Design/methodology/approachThrough an online questionnaire, the study uses a large sample of 6,584 users from 44 low-cost fitness centres from different cities in Spain. After validating the measurement model, the hypotheses were tested through structural equation (SEM) modelling technique, noting the existence of significant relationships.FindingsThe results showed that two dimensions of perceived quality have a positive influence on perceived value (employees) and satisfaction (facilities). However, the enthused participation dimension of customer engagement also indicated an important impact on perceived value and satisfaction, thus confirming the influence of this dimension in the context of sports services for users' loyalty.Originality/valueWith a large sample, the importance of this study lies in the use of strategies to achieve a greater influence on perceived value and satisfaction, with the aim of increasing customer loyalty in fitness centres. This is why, in addition to the service quality, the influence of the customer engagement dimensions is included, which have not been previously analysed in this emerging business model.
What does expatriate success mean? Developing a comprehensive definition through a systematic literature review
Authors: El Amine Nour R. , Cascón-Pereira Rosalía 
Published: September 2023

PurposeDespite being one of the most used dependent variables in expatriate management research, no clear-cut understanding exists of what expatriate success means. Thus, this study aims to propose an integrative definition of expatriate success by providing an overview of expatriate success's dimensions, antecedents, and their interplay.Design/methodology/approachA systematic literature review (SLR) was conducted to achieve the purpose. A total of 249 empirical studies (quantitative 111, qualitative 50, mixed-methods 17), literature reviews (67) and meta-analyses (4) on expatriate success were reviewed from Web of Science and Scopus databases published from 1990 until December 2021. The study selection criteria followed the PRISMA flowchart steps, and then descriptive and network analyses were performed to identify expatriates' success dimensions, antecedents and their interplay.FindingsThe findings show the interplay among antecedents and dimensions of expatriate success across three levels (individual, interpersonal and organisational) to clarify the concept of expatriate success. Also, the study offers a comprehensive definition of expatriate success based on the dimensions identified.Research limitations/implicationsThe suggested definition of expatriate success elucidates the “atheoretical”, multidimensional and socially constructed nature of the construct and hence, calls for more “theoretical”, multidimensional and subjective considerations of the term to ground human resource management practices addressed to attain expatriates' success.Originality/valueThis paper provides an integrative definition of expatriate success, giving greater insight into the construct, in addition to critically reflecting on it.
Collaborative networks between contractors and subcontractors for infrastructure development: a comparative study of national quality award projects in China
Authors: Zong Haiyi , Wang Guangbin , Cao Dongping 
Published: September 2023

PurposeAs the foundation of social and economic development, infrastructure development projects are characterized by large initial investment, high technical requirements and thus generally delivered through complex contractor–subcontractor collaboration chains. This study aims to characterize the complexity of collaborative networks between contractors and subcontractors for infrastructure development through comparing the structural characteristics and the formation mechanisms of contractor–subcontractor collaborative networks for the following two different types of infrastructure: public works (PWCN) owned and operated by government agencies, and public utilities (PUCN) owned and operated by nongovernment agencies.Design/methodology/approachBased on the method of stochastic actor-oriented models and the longitudinal dataset of National Quality Award Projects in China during 2001–2020, this study compares how the structural characteristics of project-based collaborative networks between contractors and subcontractors for the two types of projects are different and how related micro-mechanisms, including both structure-based endogenous network effects and attribute-based exogenous homophily effects (institutional, organizational and geographical homophily), collectively underpin the formation of the networks.FindingsThe empirical results provide evidence that while the two networks are both characterized by relatively low levels of network density, PWCN is more globally connected around a minority of superconnected contractors as compared with PUCN. The results further reveal that compared with PUCN, the formation of PWCN is more significantly related to the structure-based anti in-isolates effect, suggesting that PWCN is more open for new entrant subcontractors. With regard to the attribute-based homophily effects, the results provide evidence that while both significantly and positively related to the effects of organizational (same company group) and geographical homophily (same location), the formation of PWCN and PUCN is oppositely driven by the institutional homophily effect (same ownership type).Originality/valueAs an exploratory effort of using network perspective to investigate the formation mechanisms of contractor–subcontractor relationships in the infrastructure development domain, this study contributes to a network and self-organizing system view of how contractors select subcontractors in different types of infrastructure projects. The study also provides insights into how contractor–subcontractor collaborative relationships can be better manipulated to promote the development of complex infrastructure in different contexts.
Solution of discrete time–cost trade-off problem with adaptive search domain
Authors: Bettemir Önder Halis , Birgonul M. Talat 
Published: September 2023

PurposeExact solution of time–cost trade-off problem (TCTP) by the state-of-the-art meta-heuristic algorithms can be obtained for small- and medium-scale problems, while satisfactory results cannot be obtained for large construction projects. In this study, a hybrid heuristic meta-heuristic algorithm that adapts the search domain is developed to solve the large-scale discrete TCTP more efficiently.Design/methodology/approachMinimum cost slope–based heuristic network analysis algorithm (NAA), which eliminates the unfeasible search domain, is embedded into differential evolution meta-heuristic algorithm. Heuristic NAA narrows the search domain at the initial phase of the optimization. Moreover, activities with float durations higher than the predetermined threshold value are eliminated and then the meta-heuristic algorithm starts and searches the global optimum through the narrowed search space. However, narrowing the search space may increase the probability of obtaining a local optimum. Therefore, adaptive search domain approach is employed to make reintroduction of the eliminated activities to the design variable set possible, which reduces the possibility of converging into local minima.FindingsThe developed algorithm is compared with plain meta-heuristic algorithm with two separate analyses. In the first analysis, both algorithms have the same computational demand, and in the latter analysis, the meta-heuristic algorithm has fivefold computational demand. The tests on case study problems reveal that the developed algorithm presents lower total project costs according to the dependent t-test for paired samples with α = 0.0005.Research limitations/implicationsIn this study, TCTP is solved without considering quality or restrictions on the resources.Originality/valueThe proposed method enables to adapt the number of parameters, that is, the search domain and provides the opportunity of obtaining significant improvements on the meta-heuristic algorithms for other engineering optimization problems, which is the theoretical contribution of this study. The proposed approach reduces the total construction cost of the large-scale projects, which can be the practical benefit of this study.
LoGE: an unsupervised local-global document extension generation in information retrieval for long documents
Authors: Ayoub Oussama , Rodrigues Christophe , Travers Nicolas 
Published: September 2023

Purpose
This paper aims to manage the word gap in information retrieval (IR) especially for long documents belonging to specific domains. In fact, with the continuous growth of text data that modern IR systems have to manage, existing solutions are needed to efficiently find the best set of documents for a given request. The words used to describe a query can differ from those used in related documents. Despite meaning closeness, nonoverlapping words are challenging for IR systems. This word gap becomes significant for long documents from specific domains.

Design/methodology/approach
To generate new words for a document, a deep learning (DL) masked language model is used to infer related words. Used DL models are pretrained on massive text data and carry common or specific domain knowledge to propose a better document representation.

Findings
The authors evaluate the approach of this study on specific IR domains with long documents to show the genericity of the proposed model and achieve encouraging results.

Originality/value
In this paper, to the best of the authors’ knowledge, an original unsupervised and modular IR system based on recent DL methods is introduced.
Beneath the surface: a bibliometric analysis of the hidden risks and costs of blockchain technology
Authors: Mahmood Zahid , Asif Muhammad , Aljuaid Mohammed , Lodhi Rab Nawaz 
Published: September 2023

PurposeThe purpose of this paper is to identify the negative aspects of blockchain technology and to shed the light on most productive years, countries, authors, sources and frequent keywords.Design/methodology/approachA Web of Science bibliographic data set containing 209 journal articles was evaluated using descriptive and network analytics. A two-step process is adopted in this study; descriptive analysis is initially carried out using RStudio to determine the most productive years, nations, sources and authors, and using co-occurrence of keyword analysis in VOSviewer, the most influential keywords are determined.FindingsThe findings reveal that 2022 is the most prolific year in terms of number of publications. It is discovered that China tops the list for having published the most articles. Similarly, the most productive authors are Kumar A and Abhishek K.Originality/valueTo the best of the authors’ knowledge, this bibliometric analysis is unique in that it takes a thorough approach to examine the negative aspects of blockchain technology and identify research trends and offer insights that might guide future research and practical solutions.
Design and analysis of a continuum manipulator for use in narrow spaces
Authors: Qi Fei , Bai Dongming , Dou Xiaoming , Zhang Heng , Pei Haishan , Zhu Jing 
Published: September 2023

Purpose
This paper aims to present a kinematics analysis method and statics based control of the continuum robot with mortise and tenon joints to achieve better control performance of the robot.

Design/methodology/approach
The kinematics model is derived by the geometric analysis method under the piecewise constant curvature assumption, and the workspace and dexterity of the proposed robot are analyzed to optimize its structure parameters. Moreover, the statics model is established by the principle of virtual work, which is used to analyze the mapping relationship between the bending deformation and the applied forces/torques. To improve the control accuracy of the robot, a model-based controller is put forward.

Findings
Results of the experiments verify the feasibility of the proposed continuum structure and the correctness of the established model and the control method. The force deviation between the theoretical value and the actual value is relatively small, and the mean value of the deviation between the driving forces is only 0.46 N, which verify the established statics model and the controller.

Originality/value
The proposed model and motion controller can realize its accurate bending control with a few deviations, which can be used as the reference for the motion planning and dynamic model of the continuum robot.
Factors predicting young consumers’ purchase intention of non-deceptive counterfeit: evidence from Gulf countries
Authors: Al Balushi Maha , Alam Mirza Mohammad Didarul , Fadlalla Adam Mohamed Ali 
Published: September 2023

Purpose
This study aims to assess both internal and external factors that impact consumer attitudes and intentions with regard to the purchase of non-deceptive counterfeits. More specifically, this study examines the impact of integrity, brand consciousness, performance risk and social risk on the attitude and in turn on the purchase intention of consumers towards non-deceptive counterfeits.

Design/methodology/approach
A total of 679 valid responses from the university students in two different Gulf countries, namely, Oman (264) and Qatar (415) were gathered through a self-administered structured questionnaire and analysed through partial least square‐structural equation modeling.

Findings
All the predictors of consumer attitude appeared significant in both country samples except integrity. However, brand consciousness appeared insignificant in the sample of Oman. In addition, Purchase intention towards the non-deceptive counterfeits was significantly predicted by attitude and subjective norm in both samples.

Originality/value
In the domain of non-deceptive counterfeit literature, the findings of the study will substantially add value. Particularly, in the Gulf country context, the impact of internal psychological and external risk factors on the attitude and purchase intention of non-deceptive counterfeits will enhance the insights of existing literature and extend and proof the robustness of the theory of reasoned action.
The impact of robots and robotic systems on businesses in the workplace: systematic review
Authors: Uğuz Arsu Şerife , Sipahi Döngül Esra 
Published: September 2023

PurposeThis study aims to identify articles examining human-robot interaction and the effects of robotic systems on employment.Design/methodology/approachIn this research, electronic searches were performed for articles published between 2000 and 2022 in Emerald, Springer, PubMed, Science Direct, Wiley and Google Scholar. In the searches of robotic systems with keywords such as “motivation, job satisfaction, job loss, performance, job giving,” 5 quantitative and 5 qualitative studies were included in the systematic review. The selected research was conducted using the Johanna Briggs Analytical Cross-Sectional Studies Checklist from the Joanna Briggs Institute (JBI) critical evaluation lists and the JBI Critical Appraisal Checklist for Qualitative Research, depending on their type. The included studies are mostly on employee-robot collaboration.FindingsAlthough the majority of the articles examined in this study are included in keywords or titles, it is determined that there is a gap in descriptive quantitative studies in the literature on the effects of employee-robot collaboration, robotic systems and robotic systems on variables such as motivation, job satisfaction, job loss, performance and employment, although they do not mention a framework that directly investigates human-robot interaction and the effects of robotic systems on employment.Research limitations/implicationsThere are several limitations in this study. One of them is that, although the databases are comprehensively scanned, only studies published in English between 2000 and 2022 are included in the systematic review. Another limitation is the heterogeneity between studies.Practical implicationsAs a result of the authors’ findings, the practical effects of the research are reflected as follows: It serves as a guide for future studies to fill the gap in the field, especially for academics and researchers working in the field of social sciences on robotic systems and intelligent automations. In addition to the qualitative studies on this subject, there is a need for the use of robotic systems in the field of human resources and management and quantitative studies with more sample sizes, especially at the corporate (firms) and individual (employees) level. Considering that the number of studies on this subject is very insufficient, this research is important in terms of shedding light on future studies.Originality/valueThe authors believe that the impact of robotic systems on employment is one of the few conceptual articles that systematically examines 6 dimensions (job satisfaction, performance, job loss, employment, motivation, employment).
Effect of flaxseed intervention on iron overload and its complications in thalassemia major patients
Authors: Fayyaz Tuba , Qadeer Muhammad Imran , Irfan Muhammad , Amjad Fareeha , Fatima Tamseel , Husnain Shahida 
Published: September 2023

Purpose
Phytochemicals are known for their iron chelation ability with no side effects. Lignans and polyphenols in flaxseed have iron-chelating and antioxidant abilities. Therefore, this study aims to assess the ability of flaxseed to reduce iron overload and minimize its negative health effects.

Design/methodology/approach
A randomized control trial was conducted. A total of 96 patients were enrolled in this study and randomized into three groups: two intervention groups had 3 or 7 g of whole flaxseed and a control group took a placebo (gram seeds). Interventions were administered for 12 weeks. A hematological profile, ferritin quantification in serum, and liver function tests were performed to evaluate the effects of flaxseed.

Findings
It was observed that flaxseed with synthetic iron chelators caused a significant reduction in ferritin levels compared with synthetic chelators. The pre-transfusion hemoglobin level was also improved in the intervention group. A significant reduction (p value 0.0003) in ferritin levels among intervention groups indicated that flaxseed reduced the iron overload. It can be concluded that flaxseed reduced iron overload in thalassemia major patients with no side effects and may reduce iron overload solely when taken in adequate quantity.

Originality/value
Although the study targets a non-specific protein-ferritin for the evaluation of iron-overload, the initial ferritin value and reduction in these levels indicate the efficacy of ferritin for reducing iron overload in thalassemia major patients. Moreover, this is the first study, to the best of the authors’ knowledge, that demonstrates the iron-chelation ability of flaxseed in thalassemia major patients, suggesting the use of flaxseed for iron chelation.