bluuebunny/crossref_metadata_2025_split huggingface dataset:
The advanced leadless leadframe package and its characteristics
Authors: Kim ByongJin , Jeon HyeongIl , Kim GiJeong , Bang WonBae , Khim JinYoung 
Published: February 2023

Purpose
The purpose of this study is to offer the advanced leadless leadframe package which achieve small form factor and high thermal and electrical performance, according to the continuous market requirement. Because of demand and trends, new package structures that can accommodate many pins (I/Os) while maintaining the excellent thermal and electrical properties of the leadframe package was studied. Different from conventional leadframe and laminate packages, it must have the large-exposed pad for thermal dissipation and design flexibility to deploy signal, ground and power selectively.

Design/methodology/approach
In this study, the routable molded leadframe (rtMLF®) package applying the pre-resin MLF substrate was introduced. The structural advantages, in terms of design flexibility, were checked by adopting the specific electrical feature. Also, the excellence of thermal and electrical performance was confirmed by simulation. The sample was manufactured, and its package robustness was validated by reliability test.

Findings
rtMLF package that enables one layer substrate but routable pattern on top layer differently from existing leadframe package was developed and studied if it overcome the limitations of leadframe and laminate products. Asymmetric land layout was designed and special features to keep electrical interference was applied to prove design flexibility. The thermal and electrical simulation has been executed to check the advantages. And key differentiations were identified. Finally, actual sample was manufactured, and structural robustness was validated by package level and board level reliability.

Originality/value
The differentiation of new semiconductor package was introduced and its excellence was verified by electrical and thermal simulation as well as reliability test. It is expected to be adopted for alternative solutions not covered by the existing products.
A Second Scottish Independence Referendum: Should the Diaspora get a Vote?
Authors: Leith Murray Stewart , Sim Duncan 
Published: February 2023

AbstractThe 2014 Scottish independence referendum settled little in terms of Scotland's constitutional future. The after‐effects of what was the largest exercise in democracy in Scottish history certainly increased Scotland's devolved authority but, following withdrawal from the EU and with continuing differences and disagreements between the Westminster and Scottish governments, there have been increasing demands for a second referendum. One aspect of these conversations has been about the voting rights of Scots living outside Scotland, whose relationship with the nation would certainly be impacted by any successful vote for Scottish independence. And yet, they have had no voice in that decision and despite calls for their inclusion in any future vote, such inclusion remains unlikely. This article examines the reasons why such inclusion would be challenging and then considers what the Scottish diaspora think about Scottish independence and voting rights, by considering qualitative responses to a survey of members of the Scottish diaspora.
Factors associated with a lack of health care utilization among Veterans after a positive suicide screen in the emergency department
Authors: Laliberte Avery Z. , Salvi Apoorva , Hooker Elizabeth , Roth Brandon , Handley Robert , Carlson Kathleen , Hynes Denise , Tuepker Anaïs , Chen Jason I. 
Published: February 2023

AbstractObjectivesMany Veterans at high risk for suicide are identified in Veterans Health Administration (VHA) emergency departments (ED). Little is known about what may predict care utilization in this population. To address this knowledge gap, we explored factors associated with Veterans' lack of VHA care utilization following a positive suicide risk screen in the ED.MethodsIn a retrospective observational study, we identified all patients who were seen in a VHA ED from October 1, 2019, to September 30, 2020. We examined factors associated with not utilizing VHA mental health (MH) and all VHA care in the 6 months following a positive suicide ED screen. Predictors included comorbidity, homelessness, and MH visit and diagnosis history.ResultsWe identified 23,446 Veterans with a positive suicide risk screen in the ED in fiscal year 2020. Overall, 4.1% had no VHA MH visits 6 months postscreen. The probability of not utilizing MH care was significantly higher for Veterans with no comorbidity (4.7% vs. 3.4% for mild comorbidity), no MH diagnosis (10.5% vs 2.8%), no past‐year MH visits (13.6% vs 2.3%), and no past‐year homelessness (5.4% vs. 1.1%). A smaller proportion of the population did not receive any VHA care 6 months postscreen (0.5%). Veterans who did not experience homelessness (0.6% vs 0.2%), had no MH diagnosis (1.6% vs. 0.3%), and had no previous MH visits (1.9% vs 0.2%) were significantly more likely to not utilize VHA care.ConclusionsVeterans who do not utilize VHA care after a positive suicide risk screen appear to have fewer documented health and housing concerns than those who do receive care. Yet, Veterans with a positive suicide risk screen who are otherwise healthy may remain at elevated risk for suicide following their ED visit. ED providers may consider enhanced follow‐up care to mitigate suicide risk for these Veterans.
STK36 splice site variant in an Australian Shepherd dog with primary ciliary dyskinesia
Authors: Christen Matthias , Ludwig‐Peisker Odette , Jagannathan Vidhya , Hetzel Udo , Schönball Ulrike , Leeb Tosso 
Published: February 2023

AbstractPrimary ciliary dyskinesia (PCD) represents a group of diseases characterized by impaired movement of cilia and subsequent health problems in diverse organ systems, notably the respiratory tract. Almost 50 candidate genes for PCD are known in humans. In this study, we investigated an Australian Shepherd dog with a history of recurrent respiratory infections and nasal discharge. A transmission electron microscopy investigation led to the diagnosis of PCD with central pair defect, in which the normal 9:2 arrangement of respiratory cilia was altered and reduced to a 9:0 arrangement. Whole genome sequencing data from the affected dog was obtained and searched for variants in PCD candidate genes that were not present in 918 control genomes from different breeds. This revealed a homozygous single base pair exchange at a splice site of STK36, XM_038585732.1:c.2868‐1G>A. The mutant allele was absent from 281 additionally genotyped Australian Shepherd dogs. RT‐PCR confirmed aberrant splicing in the affected dog with the skipping of exon 20 and the insertion of a cryptic exon, which is predicted to lead to a premature stop codon and truncation of 36% of the STK36 wild‐type open reading frame, XP_038441660.1:(p.Met957Profs*11). STK36 variants were previously reported to cause PCD in humans and mice. The knowledge from other species together with the absence of the mutant allele in more than 1000 control dogs suggests STK36:c.2868‐1G>A as the most likely candidate variant for PCD in the investigated case.
Mainstream genetic testing for high‐grade ovarian, tubal and peritoneal cancers: A tertiary referral centre experience
Authors: Srinivasa Shweta , Bowman Michelle , Titterton Leanna , Harnett Paul , Brand Alison , Kirk Judy , Ragunathan Abiramy 
Published: February 2023

BackgroundFifteen percent of ovarian, tubal, and peritoneal (OTP) invasive epithelial cancers are linked to an underlying heritable pathogenic variant (PV) in the BRCA1/2 cancer susceptibility genes. Identifying a PV has management implications for an affected individual and relatives. Cancer team‐facilitated genetic testing (mainstreaming) aims to provide equitable systematic access to genetic testing for appropriate patients.AimTo evaluate a multi‐disciplinary team (MDT)‐led mainstream germline genetic testing program for OTP cancer at a tertiary referral centre.Materials and methodsWe conducted a retrospective review of our MDT‐led mainstream genetic testing program initiated in June 2017. We included all patients diagnosed with OTP cancer registered with the hospital gynaecological oncology MDT from program initiation to December 2020. Patients were considered eligible for testing if they were diagnosed with a high‐grade epithelial OTP AND ≤70 years, OR if >70 with a first/second degree relative with breast and/or ovarian cancer OR Jewish ancestry.ResultsOf 205 women diagnosed with high‐grade epithelial OTP cancer, 140 were eligible for mainstreaming. Eight‐five percent were mainstreamed, with the gynae‐oncologists facilitating 64.5% of tests. The overall PV detection rate in BRCA1/2 was 10.1% (BRCA1 n = 9, BRCA2 n = 3). The median turnaround time (TAT) was 44.5 days (range 16–118). All women with PV were referred to the Familial Cancer Service for further assessment and five (of six eligible; 83%) were subsequently treated with polyadenosine diphosphate ribose polymerase inhibitors. Cascade testing was undertaken in 75% of families with a mean of three relatives tested per proband.ConclusionMainstreamed genetic testing is feasible, with an acceptable TAT, ensuring adequate opportunity to inform treatment decisions. Tumour testing and inclusion of moderate‐risk cancer predisposition genes in mainstreaming represent potential pathways that will require further exploration.
From the Mountains to the Sea—Ki Uta ki Tai: Ecological Enclosure, Interconnection, and Subjectivity in the Commons
Authors: Virens Abbi 
Published: February 2023

AbstractThis paper explores the ways in which the affective and material dimensions of the commons come together to produce commoner subjectivities. Threats of enclosure can draw attention to the ways in which subjectivity reproduction is dependent on an environment which enables embodied acts of care. Using the example of the East Otago Taiāpure and Waikouaiti Mātaitai, a form of customary fisheries management in New Zealand, this paper illustrates the limitations of the institutionalised commons in its capacity to create an effective caring and protective space. Historical colonial transformation of the landscape and contemporary industrial activities have resulted in an “ecological enclosure” of the area, threatening the health of the ecosystem and its ability to encourage Māori subjectivities, specifically, kaitiakitanga, a relational responsibility to care for the physical and social environment.
Editorial: considerations for expanding treatment in grey zone chronic hepatitis B patients—authorsʼ reply
Authors: Huang Rui , Wang Jian , Yan Xiaomin , Zhu Chuanwu , Wu Chao 
Published: February 2023

LINKED CONTENTThis article is linked to Wang et al papers. To view these articles, visit https://doi.org/10.1111/apt.17272 and https://doi.org/10.1111/apt.17340
Letter: the diagnostic value of ultrasound‐based versus CT‐based sarcopenia measurement in cirrhosis – authors' reply
Authors: Artru Florent , Louvet Alexandre 
Published: February 2023

LINKED CONTENTThis article is linked to Artru et al papers. To view these articles, visit https://doi.org/10.1111/apt.16080 and https://doi.org/10.1111/apt.17343
The mythology of ‘Big Data’ as a source of corporate power
Authors: Maffie Michael David 
Published: February 2023

AbstractIn this article, the author explores how companies leverage the mythology of their ‘Big Data’ as a source of power. Drawing on two case studies from the ‘gig’ economy, the author finds that the mythology of Big Data allows companies to claim a monopoly over truth about their industries, marginalizing external researchers. In doing so, companies position themselves as the only legitimate source of knowledge about labour conditions on their services, granting them influence over their regulatory environment.
Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats
Authors: Manni Luigi , Leotta Eleonora , Mollica Ilia , Serafino Annalucia , Pignataro Annabella , Salvatori Illari , Conti Giorgio , Chiaretti Antonio , Soligo Marzia 
Published: February 2023

Background and PurposeTraumatic brain injury (TBI) comprises a primary injury directly induced by impact, which progresses into a secondary injury leading to neuroinflammation, reactive astrogliosis, and cognitive and motor damage. To date, treatment of TBI consists solely of palliative therapies that do not prevent and/or limit the outcomes of secondary damage and only stabilize the deficits. The neurotrophin, nerve growth factor (NGF), delivered to the brain parenchyma following intranasal application, could be a useful means of limiting or improving the outcomes of the secondary injury, as suggested by pre‐clinical and clinical data.Experimental ApproachWe evaluated the effect of acute intranasal treatment of young (20‐postnatal day) rats, with NGF in a TBI model (weight drop/close head), aggravated by hypoxic complications. Immediately after the trauma, rats were intranasally treated with human recombinant NGF (50 μg·kg−1), and motor behavioural test, morphometric and biochemical assays were carried out 24 h later.Key ResultsAcute intranasal NGF prevented the onset of TBI‐induced motor disabilities, and decreased reactive astrogliosis, microglial activation and IL‐1β content, which after TBI develops to the same extent in the impact zone and the hypothalamus.Conclusion and ImplicationsIntranasal application of NGF was effective in decreasing the motor dysfunction and neuroinflammation in the brain of young rats in our model of TBI. This work forms an initial pre‐clinical evaluation of the potential of early intranasal NGF treatment in preventing and limiting the disabling outcomes of TBI, a clinical condition that remains one of the unsolved problems of paediatric neurology.
The intersections of socioeconomic position, gender, race/ethnicity and nationality in relation to oral conditions among American adults
Authors: Madera Meisser , Delgado‐Angulo Elsa Karina , Bashir Nasir Zeeshan , Bernabe Eduardo 
Published: February 2023

AbstractObjectiveThe objective of the study was to evaluate how gender, socioeconomic position (SEP), race/ethnicity and nationality intersect to structure social inequalities in adult oral health among American adults.MethodsData from adults aged 20 years or over who participated in the National Health and Nutrition Examination Survey (NHANES) 2009–2018 were analysed. The outcomes were poor self‐rated oral health and edentulism among all adults (n = 24 541 and 21 446 participants, respectively) and untreated caries and periodontitis among dentate adults (n = 16 483 and 9829 participants, respectively). A multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) was conducted for each outcome, by nesting individuals within 48 intersectional strata defined as combinations of gender, SEP, race/ethnicity and nationality. Intersectional measures included the variance partition coefficient (VPC), the proportional change in variance (PCV) and predicted excess probability due to interaction.ResultsSubstantial social inequalities in the prevalence of oral conditions among adults were found, which were characterized by high between‐stratum heterogeneity and outcome specificity. The VPCs of the simple intersectional model showed that 9.4%–12.7% of the total variance in the presentation of oral conditions was attributed to between‐stratum differences. In addition, the PCVs from the simple intersectional model to the intersectional interaction model showed that 84.1%–97.1% of the stratum‐level variance in the presentation of oral conditions was attributed to the additive effects of gender, SEP, race/ethnicity and nationality. The point estimates of the predictions for some intersectional strata were suggestive of an intersectional interaction effect. However, the 95% credible intervals were very wide and the estimations inconclusive.ConclusionsThis analysis highlights the value of the intersectionality framework to understand heterogeneity in social inequalities in oral health. These inequalities were mainly due to the additive effect of the social identities defining the intersectional strata, with no evidence of interaction effects.
Implication of heart rate variability on cerebral small vessel disease: A potential therapeutic target
Authors: Tian Yu , Yao Dongxiao , Pan Yuesong , Wang Mengxing , Meng Xia , Zhao Xingquan , Liu Liping , Wang Yongjun , Wang Yilong 
Published: February 2023

AbstractObjectiveThis study aimed to investigate the relationships of heart rate variability (HRV) with the presence, severity, and individual neuroimaging markers of cerebral small vessel disease (CSVD).MethodA total of 4676 participants from the Third China National Stroke Registry (CNSR‐III) study were included in this cross‐sectional analysis. CSVD and its markers, including white matter hyperintensity (WMH), lacunes, enlarged perivascular spaces (EPVS), cerebral microbleeds (CMBs), and brain atrophy (BA), were evaluated. Two common HRV parameters, including the square root of the mean of the sum of the squares of differences between adjacent N–N intervals (RMSSD) and the standard deviation of all N–N intervals (SDNN), were used to evaluate the function of the autonomic nervous system (ANS). Binary or ordinal logistic regression analyses were performed to investigate the association between HRV and CSVD. In addition, two‐sample mendelian randomization (MR) analyses were performed to investigate the causality of HRV with CSVD.ResultsRMSSD was significantly associated with total burden of CSVD (Wardlaw's scale, common odds ratio [cOR] 0.80, 95% confidence interval [CI] 0.67–0.96, p = 0.02; Rothwell's scale, cOR 0.75, 95% CI 0.60–0.93, p = 0.008) and the presence of CSVD (Rothwell, OR 0.75, 95% CI 0.60–0.93, p = 0.008). However, no significant associations between SDNN and the presence or total burden of CSVD were observed. Moreover, RMSSD was related to WMH burden (OR 0.80, 95% CI 0.66–0.96, p = 0.02), modified WMH burden (cOR 0.82, 95% CI 0.69–0.97, p = 0.02), and Deep‐WMH (OR 0.75, 95% CI 0.62–0.91, p = 0.003), while SDNN was related to Deep‐WMH (OR 0.80, 95% CI 0.66–0.96, p = 0.02) and BA (cOR 0.80, 95% CI 0.68–0.95, p = 0.009). Furthermore, adding HRV to the conventional model based on vascualr risk factors enhanced the predictive performance for CSVD, as validated by the integrated discrimination index (p < 0.05). In addition, no causality between HRV and CSVD was observed in two‐sample MR analyses.ConclusionDecreased HRV may be a potential risk factor of CSVD, implying the possible role of the ANS in the pathogenesis of CSVD.
Surface smoothness of resin composites after polishing—A systematic review and network meta‐analysis of in vitro studies
Authors: de Oliveira Ananda Gomes , Rocha Rafael Santos , Spinola Manuela da Silva , Batista Graziela Ribeiro , Bresciani Eduardo , Caneppele Taciana Marco Ferraz 
Published: February 2023

AbstractA systematic review and network meta‐analysis was performed to provide evidence for the best polishing protocol for different types of resin composites to minimize surface roughness. A search was performed in PubMed, Scopus, Web of Science, LILACS, BBO, EMBASE, and Cochrane Library on July 2, 2019 (updated in December, 2020). In vitro studies that included at least two systems for polishing resin composites and analyzed surface roughness were included. The risk of bias was evaluated. A random‐effects Bayesian‐mixed treatment comparison model was used to compare surface roughness in resin composites with the different types of polishers. Surface under the cumulative ranking curve (SUCRA) analysis was performed to rank the probability for the best polishing system. After removal of duplicates, title and abstract screening yielded 34 studies. Network meta‐analysis was not possible for hybrid and microhybrid composites. SUCRA analysis showed that abrasive paper discs allowed greater surface smoothness for nanohybrid and nanofill composites to a probability of between 83% and 91.6%. Silicon carbide brush had a 78.2% probability of being the best system for microfill composites. The use of abrasive paper disc polishers showed a favorable result in nanofill and nanohybrid resin composites. Silicon carbide brush has a greater chance of promoting a smoother surface for microfill resin composites.
Marital satisfaction in covenant versus standard marriages: Is there a difference?
Authors: Su Tom , Ledermann Thomas 
Published: February 2023

AbstractAfter the rapid increase of the American divorce rate in the late 20th century, one of the most conspicuous efforts of the marriage movement in the 1990s that was used to increase marital stability was the legislation of the covenant marriage license, a more restricted marriage license issued in three different states of the U.S. To investigate the marital life of newlywed covenant versus standard couples, a large‐scale 5‐year couple study was conducted between 1998 and 2003 in Louisiana. The present study uses this large‐sample, multiple‐wave, multiple‐group dyadic dataset to examine differences in co‐development and divorce rates in 297 covenant and 380 standard mixed‐sex couples using a multiple group growth curve modeling and survival analysis. We examined differences in marital trajectories between covenant and standard couples as well as between husbands and wives in each marital group. The results show (1) that the couples in both groups experienced, on average, declines in marital satisfaction, and such a decline was slower in covenant husbands than their wives as well as those in standard marriages, and (2) that co‐development in marital satisfaction was more prominent in standard marriages than in covenant marriages, meaning standard couple's marital satisfaction declined at a more similar rate than that of covenant couples. We provide possible explanations and discuss practical implications.