bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators to recruitment of underrepresented research participants: Perspectives of clinical research coordinators
Authors: Heffernan Marie E. , Barrera Leo , Guzman Zecilly R. , Golbeck Emily , Jedraszko Aneta M. , Hays P. Toddie , Herzog Keith A. , D’Aquila Richard T. , Ison Michael G. , McColley Susanna A. 
Published: August 2023

Abstract

Background:
Insufficient recruitment of groups underrepresented in medical research threatens the generalizability of research findings and compounds inequity in research and medicine. In the present study, we examined barriers and facilitators to recruitment of underrepresented research participants from the perspective of clinical research coordinators (CRCs).

Methods:
CRCs from one adult and one pediatric academic medical centers completed an online survey in April-May 2022. Survey topics included: participant language and translations, cultural competency training, incentives for research participation, study location, and participant research literacy. CRCs also reported their success in recruiting individuals from various backgrounds and completed an implicit bias measure.

Results:
Surveys were completed by 220 CRCs. CRCs indicated that recruitment is improved by having translated study materials, providing incentives to compensate participants, and reducing the number of in-person study visits. Most CRCs had completed some form of cultural competency training, but most also felt that the training either had no effect or made them feel less confident in approaching prospective participants from backgrounds different than their own. In general, CRCs reported having greater success in recruiting prospective participants from groups that are not underrepresented in research. Results of the implicit bias measure did not indicate that bias was associated with intentions to approach a prospective participant.

Conclusions:
CRCs identified several strategies to improve recruitment of underrepresented research participants, and CRC insights aligned with insights from research participants in previous work. Further research is needed to understand the impact of cultural competency training on recruitment of underrepresented research participants.
How does the antimicrobial stewardship provider role affect prospective audit and feedback acceptance for restricted antibiotics in a Canadian tertiary-care center?
Authors: Hammond Keely M. , Kabbani Dima , Doucette Karen E. , Smith Stephanie W. , Lau Cecilia , Bains Serena , Fong Karen , Stewart Jackson , Chen Justin Z. 
Published: August 2023

AbstractOf 731 restricted antimicrobial prescriptions subject to antimicrobial stewardship program (ASP) prospective audit and feedback (PAF) over a 3-year period, 598 PAF recommendations (82%) were fully accepted. Physician auditors had an increased odds of PAF recommendation acceptance, reinforcing the complementary role of the ASP physician in the multidisciplinary ASP team.
A contractor comparison of novel IPT tools and techniques for Brazilian peppertree (Schinus terebinthifolia) management
Authors: Bell Mackenzie E. , Enloe Stephen F. , Leary James K. , Lauer Dwight K. 
Published: August 2023

AbstractBrazilian peppertree (Schinus terebinthifolia Raddi) is a multistemmed shrub or small tree from South America that is invasive in Florida, Texas, Hawaii, and Australia. It forms multistemmed trunks with spreading branches that create dense thickets. State agencies in Florida manage it at annual costs of over $3 million, and individual plant treatment (IPT) techniques are widely used for control. Recent research testing novel hack and squirt approaches with aminopyralid and aminocyclopyrachlor and basal bark treatment with a new triclopyr formulation has shown these treatments are highly effective. However, they have not been evaluated at larger scales, which would be useful to land managers. Therefore, our objective was to compare the reduced hack and squirt technique using aminopyralid and aminocyclopyrachlor herbicides to basal bark treatment with triclopyr on a field scale. We used two contractor crews to apply treatments to twenty-four 0.2-ha plots. Treatments included aminocyclopyrachlor (120 g L−1) or aminopyralid (120 g L−1) applied with the reduced hack and squirt technique and triclopyr ester (108 g L−1) and triclopyr acid (34 g L−1) formulations applied with two basal bark treatment techniques. We confirmed that reduced hack and squirt significantly reduced the amount of herbicide and carrier applied compared with the basal bark treatments. By 540 d after treatment, aminocyclopyrachlor more effectively controlled S. terebinthifolia than aminopyralid with reduced hack and squirt and resulted in control comparable to that seen with either triclopyr basal bark treatment. These results verify reduced hack and squirt treatment with aminocyclopyrachlor and basal bark treatment with triclopyr acid as alternatives to basal bark treatment with triclopyr ester. Both resulted in significantly less herbicide use with comparable efficacy. This operational research approach has accelerated our understanding of novel IPT strategies and their implementation in the field.
Comparing input interfaces to elicit belief distributions
Authors: Crosetto Paolo , de Haan Thomas 
Published: August 2023

Abstract
This paper introduces a new software interface to elicit belief distributions of any shape: Click-and-Drag. The interface was tested against the state of the art in the experimental literature—a text-based interface and multiple sliders—and in the online forecasting industry—a distribution-manipulation interface similar to the one used by the most popular crowd-forecasting website. By means of a pre-registered experiment on Amazon Mechanical Turk, quantitative data on the accuracy of reported beliefs in a series of induced-value scenarios varying by granularity, shape, and time constraints, as well as subjective data on user experience were collected. Click-and-Drag outperformed all other interfaces by accuracy and speed, and was self-reported as being more intuitive and less frustrating, confirming the pre-registered hypothesis. Aside of the pre-registered results, Click-and-Drag generated the least drop-out rate from the task, and scored best in a sentiment analysis of an open-ended general question. Further, the interface was used to collect homegrown predictions on temperature in New York City in 2022 and 2042. Click-and-Drag elicited distributions were smoother with less idiosyncratic spikes. Free and open source, ready to use oTree, Qualtrics and Limesurvey plugins for Click-and-Drag, and all other tested interfaces are available at https://beliefelicitation.github.io/.
COMPARING BIOAPATITE AND COLLAGEN RADIOCARBON DATES FROM A 16TH CENTURY CEMETERY CONTEXT—EL JAPÓN, XOCHIMILCO, MEXICO CITY
Authors: Alarcón Tinajero Edgar , Hadden Carla S , Cherkinsky Alexander 
Published: August 2023

ABSTRACTEl Japón is a 16th century hamlet site in the marshlands of the southern Basin of Mexico in central Mesoamerica. Radiocarbon (14C) dating and OxCal modeling of human bone collagen (n = 11) identifies a range of burials at El Japón cemetery from 1550–1650 cal. CE. The refined chronology identifies use of this rural settlement well after the onset of colonial government-sponsored relocation of Indigenous people to larger settlements (congregaciones). Historically documented information in this work supports chronological modeling beyond stand-alone calibration. Stable isotopic study of bone samples demonstrates similar sources of dietary protein and carbohydrates. The similarity of carbon sources for bone apatite (bioapatite) and collagen offers security that both bone fractions are viable 14C dating opportunities. Recent extension of this work examines bioapatite 14C dates (n = 5) from the same bone samples when quality parameters are met—atomic carbon-nitrogen ratios of 3.2–3.3 and collagen yield of 10–20%. No significant difference is found between collagen and bioapatite dates of the same individuals (p = 0.17, Mann-Whitney U test). 14C dates from human bone samples in this primarily terrestrial dietary context can be successfully acquired from either collagen or bioapatite fractions.
Why ‘Reception History’ Is Not Just Another Exegetical Method: The Case Of Mark's Ending
Authors: Burnet Régis 
Published: August 2023

AbstractThe history of reception is suffering from a fundamental misunderstanding. Since the publication of Truth and Method, everyone has had the impression that reception history is just another exegetical technique. However, the heart of Gadamer's argument is not the history of the effects of the text, but the historicity of understanding: a text is seized only within the limits of the historical situation of its interpreter. To demonstrate this point, this paper takes the example of the Markan ending. Surprisingly, a 16th-century Thomistic theologian, Cajetan, and a contemporary commentary are so close that one might think they are defending the same view of the text. Both intend to maintain the canonicity of verses 9–20, but both point out that it may be adventurous to build any doctrine or practice on these verses alone. But the context is different, obviously. The first one tries to justify a conception of faith that does not depend directly on miracles; the second one affirms a hermeneutic centred on the interpreter's response, being wary of its ecclesiological drifts. This confirms that theological considerations rather than philological ones have prevailed in challenging Mark's ending.
Rezeptionskritik und Rezeptionsgeschichte des Neuen Testaments: Eine methodologische Skizze
Authors: Hoegen-Rohls Christina 
Published: August 2023

German AbstractAngesichts der fortschreitenden Publikation der Encyclopedia of the Bible and Its Reception (EBR), der Weiterarbeit an den Bänden des Evangelisch-Katholischen Kommentars zum Neuen Testament (EKK) und der Fortsetzung von Blackwell's Kommentarserie Through the Centuries lautet die Leitfrage des vorliegenden Artikels: Wie kann zur Theoretisierung und Methodisierung einer Rezeptionsgeschichte des Neuen Testaments beigetragen werden? Um diese Frage zu beantworten und Perspektiven zu entwerfen, unternimmt der Artikel den Versuch einer neuerlichen Klärung der Begriffe ‘Wirkungsgeschichte’ / ‘wirkungsgeschichtliches Bewusstsein’, ‘Auslegungsgeschichte’, ‘Rezeptionsgeschichte’ und schlägt zwei Fragenkataloge vor, die das Vorgehen einer cross-temporal und cross-cultural ausgerichteten Rezeptionskritik des Neuen Testaments inhaltlich und methodisch reflektieren und kontrollieren.
Widowhood and functional impairment: gender-specific trajectories of sensory and masticatory functions
Authors: Song Kyungeun , Kim Jinho 
Published: August 2023

AbstractDespite a large body of research on the effects of widowhood on health, little is known about whether spousal loss is related to functional impairment in widowed persons. This study examines the trajectories of functional impairment (sensory and masticatory functions) before and after spousal loss. This study also investigates whether the temporal changes in functional impairment of widowed people are gendered. Using data from the Korean Longitudinal Study of Ageing over seven waves (42,967 person-observations), this study estimated fixed effects regression models to account for unobserved individual-level heterogeneity. Gender-stratified fixed effects regression models were used to determine whether changes in functional impairment associated with spousal loss differ by gender. The results of this study indicated that the vision of widowed people began to decrease within the first year following spousal loss and persisted through the fourth and subsequent years. By contrast, mastication deterioration occurred only among widowers. Masticatory impairment began during the first year of spousal loss and lasted the entire survey period. No statistically significant reduction in hearing loss was found for both widowers and widows. The results of this study suggest that spousal loss has a long-term effect on functional impairment, particularly in vision and masticatory functions. This study also documents gender heterogeneity in the trajectories of functional impairment before and after spousal loss. Vision impairment was found to be universal among widowers and widows, whereas masticatory impairment was significant only among widows. To address the physical and psychological vulnerability of widowed people, policies should be developed early in the process of adjusting to widowhood.
Kinematic modeling and motion control of a parallel robotic antenna pedestal
Authors: He Shuai , Duan Xuechao , Qu Xianpu , Xiao Jiaxuan 
Published: August 2023

AbstractThis paper deals with kinematic modeling and motion control of a novel antenna pedestal based on parallel robotic mechanism. Its active joints are two sliders equipped with DC motors on a circular rail. The synchronous and asynchronous motions of the two sliders enable the antenna to rotate in azimuth and pitch. In order to solve the problem of trajectory deviation caused by nonlinear friction and other uncertain disturbances, the structure of the antenna is described at the beginning, and then, the kinematic model is established based on geometry method. Then, the fuzzy PI (FPI) control system is designed based on the position feedback of the driving slider to realize the trajectory tracking of the desired curve. Finally, the parameters of the FPI controller are optimized and validated by Simulink simulation experiments. The tracking performance and the effectiveness of the control algorithm on prototype are verified by experiments of typical trajectory following control.
A new approach to a powered knee prosthesis: Layering powered assistance onto strictly passive prosthesis behavior
Authors: Culver Steve C. , Vailati Léo G. , Morgenroth David C. , Goldfarb Michael 
Published: August 2023

Abstract
This article describes a novel approach to the control of a powered knee prosthesis where the control system provides passive behavior for most activities and then provides powered assistance only for those activities that require them. The control approach presented here is based on the categorization of knee joint function during activities into four behaviors: resistive stance behavior, active stance behavior, ballistic swing, and non-ballistic swing. The approach is further premised on the assumption that healthy non-perturbed swing-phase is characterized by a ballistic swing motion, and therefore, a replacement of that function should be similarly ballistic. The control system utilizes a six-state finite-state machine, where each state provides different constitutive behaviors (concomitant with the four aforementioned knee behaviors) which are appropriate for a range of activities. Transitions between states and torque control within states is controlled by user motion, such that the control system provides, to the extent possible, knee torque behavior as a reaction to user motion, including for powered behaviors. The control system is demonstrated on a novel device that provides a sufficiently low impedance to enable a strictly passive ballistic swing-phase, while also providing sufficiently high torque to offer powered stance-phase knee-extension during activities such as step-over stair ascent. Experiments employing the knee and control system on an individual with transfemoral amputation are presented that compare the functionality of the power-supplemented nominally passive system with that of a conventional passive microprocessor-controlled knee prosthesis.
Hedgehog signaling in tissue homeostasis, cancers and targeted therapies
Authors: Jing Junjun , Wu Zhuoxuan , Wang Jiahe , Luo Guowen , Lin Hengyi , Fan Yi , Zhou Chenchen 
Published: August 2023

AbstractThe past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor prognosis and even increased mortality. Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer. A variety of drugs have been developed, including small molecule inhibitors, natural compounds, and long non-coding RNA (LncRNA), some of which are approved for clinical use. This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer. Furthermore, we address status quo and limitations of targeted therapies of HH signaling pathway. Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer, as well as opportunities and challenges of therapeutic targets for cancer.
Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
Authors: Park Soon Young , Jeong Kang Jin , Poire Alfonso , Zhang Dong , Tsang Yiu Huen , Blucher Aurora S. , Mills Gordon B. 
Published: August 2023

AbstractFerroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but not the xCT transporter, is selectively elevated in luminal breast cancer. Consistent with this observation, the majority of luminal breast cancer cell lines are exquisitely sensitive to RSL3 with limited sensitivity to erastin. In RSL3-resistant, but not sensitive, luminal breast cancer cell lines, RSL3 induces HER2 pathway activation. Irreversible HER2 inhibitors including neratinib reversed RSL3 resistance in constitutively RSL3-resistant cell lines. Combination treatment with RSL3 and neratinib increases ferroptosis through mitochondrial iron-dependent reactive oxygen species production and lipid peroxidation. RSL3 also activated replication stress and concomitant S phase and G2/M blockade leading to sensitivity to targeting the DNA damage checkpoint. Together, our data support the exploration of RSL3 combined with irreversible HER2 inhibitors in clinical trials.
LINC02015 modulates the cell proliferation and apoptosis of aortic vascular smooth muscle cells by transcriptional regulation and protein interaction network
Authors: Liu Fangyu , Wang Yulin , Huang Xitong , Liu Dingqian , Ding Wenjun , Lai Hao , Wang Chunsheng , Ji Qiang 
Published: August 2023

AbstractLong intergenic nonprotein coding RNA 2015 (LINC02015) is a long non-coding RNA that has been found elevated in various cell proliferation-related diseases. However, the functions and interactive mechanism of LINC02015 remain unknown. This study aimed to explore the role of LINC02015 in the cell proliferation and apoptosis of vascular smooth muscle cells (VSMCs) to explain the pathogenesis of aortic diseases. Ascending aorta samples and angiotensin-II (AT-II) treated primary human aortic VSMCs (HAVSMCs) were used to evaluate the LINC02015 expression. RNA sequencing, chromatin isolation by RNA purification sequencing, RNA pull-down, and mass spectrometry (MS) were applied to explore the potential interacting mechanisms. LINC02015 expression was found elevated in aortic dissection and AT-II-treated HAVSMCs. Cell proliferation and cell cycle were activated in HAVSMCs with LINC02015 knockdown. The cyclins family and caspase family were found to participate in regulating the cell cycle and apoptosis via the NF-κB signaling pathway. RXRA was discovered as a possible hub gene for LINC02015 transcriptional regulating networks. Besides, the protein interaction network of LINC02015 was revealed with candidate regulating molecules. It was concluded that the knockdown of LINC02015 could promote cell proliferation and inhibit the apoptosis of HAVSMCs through an RXRA-related transcriptional regulation network, which could provide a potential therapeutic target for aortic diseases.
iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays
Authors: Fay Meredith E. , Oshinowo Oluwamayokun , Iffrig Elizabeth , Fibben Kirby S. , Caruso Christina , Hansen Scott , Musick Jamie O. , Valdez José M. , Azer Sally S. , Mannino Robert G. , Choi Hyoann , Zhang Dan Y. , Williams Evelyn K. , Evans Erica N. , Kanne Celeste K. , Kemp Melissa L. , Sheehan Vivien A. , Carden Marcus A. , Bennett Carolyn M. , Wood David K. , Lam Wilbur A. 
Published: August 2023

AbstractWhile microscopy-based cellular assays, including microfluidics, have significantly advanced over the last several decades, there has not been concurrent development of widely-accessible techniques to analyze time-dependent microscopy data incorporating phenomena such as fluid flow and dynamic cell adhesion. As such, experimentalists typically rely on error-prone and time-consuming manual analysis, resulting in lost resolution and missed opportunities for innovative metrics. We present a user-adaptable toolkit packaged into the open-source, standalone Interactive Cellular assay Labeled Observation and Tracking Software (iCLOTS). We benchmark cell adhesion, single-cell tracking, velocity profile, and multiscale microfluidic-centric applications with blood samples, the prototypical biofluid specimen. Moreover, machine learning algorithms characterize previously imperceptible data groupings from numerical outputs. Free to download/use, iCLOTS addresses a need for a field stymied by a lack of analytical tools for innovative, physiologically-relevant assays of any design, democratizing use of well-validated algorithms for all end-user biomedical researchers who would benefit from advanced computational methods.
Ce-mediated molecular tailoring on gigantic polyoxometalate {Mo132} into half-closed {Ce11Mo96} for high proton conduction
Authors: Li Xue-Xin , Li Cai-Hong , Hou Ming-Jun , Zhu Bo , Chen Wei-Chao , Sun Chun-Yi , Yuan Ye , Guan Wei , Qin Chao , Shao Kui-Zhan , Wang Xin-Long , Su Zhong-Min 
Published: August 2023

AbstractPrecise synthesis of polyoxometalates (POMs) is important for the fundamental understanding of the relationship between the structure and function of each building motif. However, it is a great challenge to realize the atomic-level tailoring of specific sites in POMs without altering the major framework. Herein, we report the case of Ce-mediated molecular tailoring on gigantic {Mo132}, which has a closed structural motif involving a never seen {Mo110} decamer. Such capped wheel {Mo132} undergoes a quasi-isomerism with known {Mo132} ball displaying different optical behaviors. Experiencing an ‘Inner-On-Outer’ binding process with the substituent of {Mo2} reactive sites in {Mo132}, the site-specific Ce ions drive the dissociation of {Mo2*} clipping sites and finally give rise to a predictable half-closed product {Ce11Mo96}. By virtue of the tailor-made open cavity, the {Ce11Mo96} achieves high proton conduction, nearly two orders of magnitude than that of {Mo132}. This work offers a significant step toward the controllable assembly of POM clusters through a Ce-mediated molecular tailoring process for desirable properties.