bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection of Optimal Well Trajectory Using Multi-Objective Genetic Algorithm and TOPSIS Method
Authors: Yavari Hossein , Qajar Jafar , Aadnoy Bernt Sigve , Khosravanian Rasool 
Published: August 2023

AbstractThis study presents a novel approach for optimizing well paths in extended reach drilling (ERD) wells. Different trajectories can be used for ERD wells, each with its pros and cons. Previous research overlooked certain objective functions in single-objective optimization and lacked an autonomous method for selecting the best solution from Pareto optimal solutions in multi-objective optimizations. Furthermore, they lacked comparing different profiles in well design. Risk assessment and operational factors, which greatly influence optimization and drilling success, were insufficiently considered. This study utilized the multi-objective genetic algorithm (MOGA) and the technique for order preference by similarity to an ideal solution (TOPSIS) method to select the optimal well path based on torque, wellbore length, risk (e.g., keyseat), and required tools. First, all possible trajectories were determined, and MOGA identified the optimal path with minimal torque and length. The fuzzy decision-making method automatically selected the best solution from the Pareto optimal solution set. The associated risks and required tools are evaluated for each trajectory. Finally, the TOPSIS method selected the optimal trajectory based on torque, length, risks, and required tools. The case study demonstrated that the undersection path was the most advantageous trajectory for ERD wells, with a 60% closeness to the ideal state. The multiple build trajectory achieved 57% closeness, while the build and hold and double build paths had lower closeness values (43 and 28%, respectively). Consequently, it can be inferred that in the context of ERD wells, it is preferable to carry out the deviation process at deeper depths.
Cofilin-1 induces acute kidney injury via the promotion of endoplasmic reticulum stress-mediated ferroptosis
Authors: Lin Sihao , Wang Jie , Cao Bin , Huang Yang , Sheng Xujun , Zhu Yingjian 
Published: August 2023

AbstractIschemia–reperfusion injury (IRI) leads to acute kidney injury (AKI), which poses serious threat to public health and society. Many clinical studies were conducted to evaluate several biomarkers in AKI, among which Cofilin-1 remains to be a very promising one. To explore the potential mechanism of Cofilin-1 in AKI, we established an oxygen-glucose-deprivation (OGD)-induced AKI cell model. The overexpression and knock-down Cofilin-1 were used for gain- and loss-of-function. Pharmacological inhibitors were employed to study the related pathways. The results showed that Cofilin-1 was significantly upregulated in AKI cells, knocking down Cofilin-1 protected cells against the effect of OGD treatment and alleviated AKI phenotypes. Overexpression of Cofilin-1 might induce AKI by triggering ferroptosis, inhibiting NF-κB signaling or ER stress pathway attenuated Cofilin-1 induced lipid peroxidation and AKI. We also validated our findings in IRI-induced AKI mouse models in vivo. Our work elucidated that Cofilin-1 might induce AKI via promoting ER stress-mediated ferroptosis and argues it as a biomarker for early diagnosis of AKI. We also expect to offer novel insights on future therapeutic interventions.
From art-science to art-science-in-the-making: transcending boundaries in higher education by (de)constructing them
Authors: van Baalen Wander Matijn 
Published: August 2023

AbstractIn Latour’s bookScience in Action, readers are encouraged to use science-in-the-making as an entry point for understanding science instead of reinforcing the stable reality of ready made science. Building on his work, this study employs an art-science-in-the-making approach to trace how a new art-science initiative is helped into being. The ethnographic work centers on the development of an interinstitutional dual degree program between two art schools and a university in Rotterdam, the Netherlands. Particular attention is paid to the ways in which mundane, bureaucratic practices feed into the stabilization of the new art-science initiative. Too often, these practices remain outside scholarly discussions on art-science. This article argues that being attentive to the practices of “paper shufflers”, to borrow Latour’s terminology, aids our thinking through encounters across difference. Themodus operandiof holding the new intersection together is conceptualized as a mode of syncretism of continuous repair. This modality of being together points to the tendency not to avoid disruptions or threats, but to continuously attend to them anew.
Past changes in and present status of the coastal carbon cycle
Authors: Rixen T. 
Published: August 2023

AbstractData were obtained from the literature to identify past changes in and the present status of the coastal carbon cycle. They indicate that marine coastal ecosystems driving the coastal carbon cycle cover, on average, 5.8% of the Earth’s surface and contributed 55.2% to carbon transport from the climate-active carbon cycle to the geological carbon cycle. The data suggest that humans not only increase the CO2concentration in the atmosphere but also mitigate (and before 1860 even balanced) their CO2emissions by increasing CO2storage within marine coastal ecosystems. Soil degradation in response to the expansion and intensification of agriculture is assumed to be a key process driving the enhanced CO2storage in marine coastal ecosystems because it increases the supply of lithogenic matter that is known to favour the burial of organic matter in sediments. After 1860, rising CO2concentrations in the atmosphere indicate that enhanced CO2emissions caused by land-use changes and the burning of fossil fuel disturbed what was a quasi-steady state before. Ecosystem restoration and the potential expansion of forest cover could mitigate the increase of atmospheric CO2concentrations, but this carbon sink to the atmosphere is much too weak to represent an alternative to the reduction of CO2emission in order to keep global warming below 1.5–2.°C. Although the contribution of benthic marine coastal ecosystems to the global CO2uptake potential of ecosystem restoration is only around 6%, this could be significant given national carbon budgets. However, the impact on climate is still difficult to quantify because the associated effects on CH4and N2O emissions have not been established. Addressing these uncertainties is one of the challenges faced by future research, as are related issues concerning estimates of carbon fluxes between the climate-active and the geological carbon cycle and the development of suitable methods to quantify changes in the CO2uptake of pelagic ecosystems in the ocean.
Cost-effectiveness of social media advertising as a recruitment tool: A systematic review and meta-analysis
Authors: Tsaltskan Vladislav , Sanchez Baez Roel , Firestein Gary S. 
Published: August 2023

Abstract

Background:
Recruitment of study participants is challenging and can incur significant costs. Social media advertising is a promising method for recruiting clinical studies and may improve cost efficiency by targeting populations likely to match a study’s qualifications. Prior systematic reviews of social media as a recruitment tool have been favourable, however, there are no meta-analyses of its cost-effectiveness.

Methods:
Studies evaluating recruitment costs through social media and non-social media methods were identified on MEDLINE and EMBASE. Articles were screened through a two-step process in accordance with PRISMA guidelines. Cost data were extracted from selected articles and meta-analyzed using the Mantel-Haenszel method. The primary outcome was the relative cost-effectiveness of social media compared to non-social media recruitment, defined as the odds ratio of recruiting a participant per US dollar spent. The secondary outcome was the cost-effectiveness of social media recruitment compared to other online recruitment methods only.

Results:
In total, 23 studies were included in the meta-analysis. The odds ratio of recruiting a participant through social media advertising compared to non-social media methods per dollar spent was 1.97 [95% CI 1.24–3.00, P = 0.004]. The odds ratio of recruiting a participant through social media compared to other online methods only was 1.66 [95% CI 1.02–2.72, P = 0.04].

Conclusions:
Social media advertising may be more cost-effective than other methods of recruitment, however, the magnitude of cost-effectiveness is highly variable between studies. There are limited data on newer social media platforms and on difficult-to-reach populations such as non-English speakers or older individuals.
Applying real-world data from expanded-access (“compassionate use”) patients to drug development
Authors: Wasser June S. , Greenblatt David J. 
Published: August 2023

Abstract
Our drug development process has produced many life-saving medications, but patients experiencing rare diseases and similar conditions often are left with limited options for treatment. For an approved treatment to be developed, research on a new candidate or existing drug must validate safety and efficacy based on contemporary research expectations. Randomized clinical trials are conducted for this purpose, but they are also costly, laborious, and time-consuming. For this reason, The 21st Century Cures Act mandates that the US Food and Drug Administration look for alternative methods for approving drugs, in particular exploring the uses of real-world data and evidence. Expanded access (“compassionate use”) is a pathway for the clinical treatment of patients using drugs that are not yet approved for prescribing in the United States. Using real-world evidence generated from expanded-access patients presents an opportunity to provide critical data on patient outcomes that can serve regulatory approval in conjunction with other observational datasets or clinical trials, and in limited circumstances may be the best data available for regulatory review. In doing so, we may also support and encourage patient-centered care and a personalized medicine approach to drug development.
Toggling: How Shifts between Deontology and Virtue Ethics Undermine Public Moral Discourse about Gender and Race
Authors: Zager Sarah 
Published: August 2023

AbstractThis article argues that shifts between deontological and virtue-ethical moral reasoning hamper public moral conversations about misogyny and racism. Using examples ranging from sexual assault to police violence, I show that when someone is accused of committing a moral wrong, they often respond by shifting from deontological to virtue-ethical modes of analysis. This kind of “toggling” between the two enables a person to claim that they are “a good person” even when they have violated important moral rules. In this way, toggling shuts down or makes incoherent our efforts to call one another to moral account, especially (but by no means exclusively) when we are attempting to address issues of systemic oppression and discrimination, including misogyny and racism.
Risky Inquiry: Developing an Ethics for Philosophical Practice
Authors: Basu Rima 
Published: August 2023

AbstractPhilosophical inquiry strives to be the unencumbered exploration of ideas. That is, unlike scientific research, which is subject to ethical oversight, it is commonly thought that it would either be inappropriate, or that it would undermine what philosophy fundamentally is, if philosophical research were subject to similar ethical oversight. Against this, I argue that philosophy is in need of a reckoning. Philosophical inquiry is a morally hazardous practice with its own risks. There are risks present in the methods we employ, risks inherent in the content of the views under consideration, and risks to the subjects of our inquiry. Likely, there are more risks still. However, by starting with the identification of these three risks we can demonstrate not only why an ethics of practice is needed but also which avenues are the most promising for developing an ethics for philosophical practice. Although we might just be in the business of asking questions, we do not merely, in virtue of engaging in philosophical inquiry, absolve ourselves of responsibility for the risks that inquiry incurs.
The proportion of triangles in a class of anisotropic Poisson line tessellations
Authors: Heerten Nils , Krecklenberg Julia , Thäle Christoph 
Published: August 2023

AbstractStationary Poisson processes of lines in the plane are studied, whose directional distributions are concentrated on
$k\geq 3$
equally spread directions. The random lines of such processes decompose the plane into a collection of random polygons, which form a so-called Poisson line tessellation. The focus of this paper is to determine the proportion of triangles in such tessellations, or equivalently, the probability that the typical cell is a triangle. As a by-product, a new deviation of Miles’s classical result for the isotropic case is obtained by an approximation argument.
The impact of wine tasters’ expectations on wine quality ratings and willingness-to-pay
Authors: Masset Philippe , Raub Steffen 
Published: August 2023

AbstractIs it possible to exploit cognitive biases so that a non-professional taster prefers one wine to several other absolutely identical wines? To address this question, three complementary experiments were carried out. Each time, five wines were tasted blind in a tasting laboratory by 24 to 34 tasters. Converging evidence from the experiments shows that participants were not capable of identifying that some of the wines they were tasting were absolutely identical. Moreover, the results show that by providing information about the wines’ ratings, prices, or reputation, tasters’ expectations can be modified, and, as a result, their evaluations of the wines can be altered. Specifically, we show that it is possible to modify the ranking between different wines and to get tasters to prefer a wine over other absolutely identical wines. Finally, a surprising finding was that experienced tasters express stronger opinions and adapt their evaluations more strongly after being given manipulative information on the wines they taste.
Tracing thick and thin concepts through corpora
Authors: Reuter Kevin , Baumgartner Lucien , Willemsen Pascale 
Published: August 2023

AbstractPhilosophers and linguists currently lack the means to reliably identify evaluative concepts and measure their evaluative intensity. Using a corpus-based approach, we present a new method to distinguish evaluatively thick and thin adjectives like ‘courageous’ and ‘awful’ from descriptive adjectives like ‘narrow,’ and from value-associated adjectives like ‘sunny.’ Our study suggests that the modifiers ‘truly’ and ‘really’ frequently highlight the evaluative dimension of thick and thin adjectives, allowing for them to be uniquely classified. Based on these results, we believe our operationalization may pave the way for a more quantitative approach to the study of thick and thin concepts.
Bureaucratic autonomy and the policymaking capacity of United States agencies, 1998–2021
Authors: Bednar Nicholas Ryan 
Published: August 2023

AbstractDespite a renewed interest in the health of the US administrative state, the absence of meaningful time-series measures of bureaucratic capacity hinders the testing of core theories of bureaucratic and executive politics. Using over 190 million personnel records, I estimate 5590 yearly policymaking-capacity scores for 261 unique agencies from 1998 to 2021. These measures provide an invaluable tool as either an independent or dependent variable in studies of administrative policymaking. To illustrate the value of these measures, I test longstanding theories about the relationship between bureaucratic autonomy and capacity. In contrast with emerging survey research, this study demonstrates that agencies with higher levels of structural independence have higher levels of policymaking capacity.
Less is more: partial larvicidal efficacy of plant leachate leads to larger Aedes aegypti mosquitoes
Authors: Marsaro Isabella Bodanese , Cozzer Gilberto Dinis , Cararo Emanuel Rampanelli , Brito Raquel De , Borges William Gabriel , Dal Magro Jacir , Lima-Rezende Cássia Alves , Rezende Renan de Souza 
Published: August 2023

AbstractMajor efforts to control the population of Aedes aegypti mosquitoes involve the use of synthetic insecticides, which can be harmful to the environment. Most plant compounds are eco-friendly and some of them have biocontrol potential, whereas a fraction of these compounds is released into the environment through the leaf-leaching process. We evaluated the effects of secondary compounds from Ateleia glazioviana and Eucalyptus grandis senescent leaf leachates on Ae. aegypti larval mortality, adult emergence time, and wing size using a microcosm approach. The microcosms consisted of 10 larvae kept in water (control) and under four treatments with leachates from a combination of plant species and leaching time (7 or 14 days). Chemical analyses of the leachates showed the presence of carboxaldehyde and Heptatriocotanol, which have antimicrobial properties, potentially reducing the food available for larvae. β-Sitosterol, Stigmasterol, α-Amyrin, and Lupeol are compounds with inhibitory, neurotoxic, and larvicidal effects. Both plant species’ leachates increased larval mortality and decreased emergence time due to the presence of compounds toxic to the larvae. Larger organisms emerged in treatments with 7-days leachates, likely due to the high concentration of dissolved organic matter in the leachates. The higher mortality in 7-days leachates may also increase the organic matter from co-specific decomposition, improving adult size. Therefore, if the mosquito population is not locally extinct, compounds present in leaf leachates may act as a resource enhancing larvae growth, potentially increasing survivors’ fitness. In conclusion, biocontrol attempts using urban green spaces may have unexpected outcomes, such as resulting in larger pest organisms.
MASSIS AMERINA NON PERVSTIS (STAT. SILV. 1.6.18): ANOTHER ITALIAN PASTRY?
Authors: Krasne Darcy A. 
Published: August 2023

AbstractThis article proposes that untethering amerina at Stat. Silv. 1.6.18 from Pliny's mention of varieties of apples and pears called Amerina allows us to read the line as instead referring to a type of pastry originating in Umbrian Ameria, which is within ancient naming practices for pastries and fits better into the context of the catalogue in which the line occurs. In this case, the second half of the catalogue is closely akin to the crustulum et mulsum donative of wealthy Italian patrons in the early empire.
Celtic Nationalisms and the Global Break-up of Britain
Authors: Jackson Ben 
Published: August 2023

AbstractThis response to Stuart Ward'sUntied Kingdomexamines his treatment of Scottish and Welsh nationalisms. This is a crucial part of the book because it is here that Ward completes his narrative arc, which depicts the loss of empire as a fundamentally destabilising force for the UK state and its basis in a shared British identity. So how should we think about the pressure that decolonisation places on British identity within Britain? While admiring much of Ward's treatment of this question, this response suggests that he underestimates the importance of post-war social democracy as a possible alternative basis for British identity and the decay of that social democracy as a causal factor in the rise of Scottish and Welsh nationalisms.
A shared novelty-seeking basis for creativity and curiosity
Authors: Ivancovsky Tal , Baror Shira , Bar Moshe 
Published: August 2023

Abstract
Curiosity and creativity are central pillars of human growth and invention. Although they have been studied extensively in isolation, the relationship between them has not yet been established. We propose that both curiosity and creativity emanate from the same mechanism of novelty seeking. We first present a synthesis showing that curiosity and creativity are affected similarly by a number of key cognitive faculties such as memory, cognitive control, attention, and reward. We then review empirical evidence from neuroscience research, indicating that the same brain regions are involved in both curiosity and creativity, focusing on the interplay between three major brain networks: the default mode network, the salience network, and the executive control network. After substantiating the link between curiosity and creativity, we propose a novelty-seeking model (NSM) that underlies them and suggests that the manifestation of the NSM is governed by one's state of mind.
Toward a theory of minority-party influence in the U.S. Congress: whip counts, amendment votes, and minority leverage in the house
Authors: Jenkins Jeffery A. , Monroe Nathan W. , Provins Tessa 
Published: August 2023

AbstractThe literature on congressional decision-making has largely ignored the influence of the minority party in the legislative process. This follows from the widely held belief that the majority party dominates the agenda-setting process. Though the minority party rarely achieves major policy success in Congress, we argue that the minority has significantly more influence over the legislative agenda than is commonly believed. We posit that, under some conditions, the minority has enough bargaining leverage to get floor votes on their proposals, in the form of both amendments and bills. We test our theoretical expectations with a novel design utilizing whip count data from the House and show that when a whip count on a bill occurs, the likelihood of a minority amendment disappointment and a majority amendment roll increases, respectively. This suggests that the more leverage the minority party has, the more we see their legislative proposals on the floor.
Labour force transitions and changes in quality of life at age 50–55 years: evidence from a birth cohort study
Authors: Watts Paul , Bartley Mel , Blane David , Netuveli Gopalakrishnan 
Published: August 2023

AbstractIn the context of an ageing population and longer working lives, the impact of increasing rates of early exit from the labour force on quality of life is a particularly current concern. However, relatively little is known about the impact on quality of life of later-life labour force transitions and various forms of early exit from the labour force, compared to remaining in employment. This paper examines lifecourse labour force trajectories and transitions in relation to change in quality of life prior to the State Pension Age. Lifecourse data on early life circumstances, labour force trajectories and labour force transitions from 3,894 women and 3,528 men in the National Child Development Study (1958 British Birth Cohort) were examined in relation to change in quality of life, measured by a short-form version of CASP, between the ages of 50 and 55. Women and men differed in the types of labour force transition associated with positive change in quality of life, with men more frequent beneficiaries. For both men and women, labour force exit due to being sick or disabled was associated with a negative change in quality of life, whereas joining the labour force was associated with a positive change in quality of life. Moving into retirement was associated with a positive change in men's quality of life, but not women's. Moving from full-time to part-time employment was associated with a positive change in women's quality of life but not men's. The findings that stand out for their policy relevance are: the threat to the quality of life of both women and men from early labour force exit due to limiting longstanding illness; and women are less likely to experience beneficial labour force exit in the later years of their working life, but are more likely to benefit from a reduction in working hours.