bluuebunny/crossref_metadata_2025_split huggingface dataset:
Untargeted metabolomics revealing changes in aroma substances in flue-cured tobacco
Authors: Zou Ling , Su Jiaen , Xu Tianyang , Ji Xinwei , Wang Tao , Chen Yi , Jiang Yonglei , Qiu Jingwen , Zhang Qi , Hu Binbin 
Published: April 2023

Abstract
The composition and content of aroma substances in flue-cured tobacco (Nicotiana tabacum L.) will affect the quality of tobacco. To investigate the correlation between various aroma substances of K326 before and after flue-curing, and their impact on tobacco quality and diversity, this study employed the middle leaves of K326 and KRK26 as test materials. Samples were collected both before and after flue-curing for untargeted metabolomics analysis. The results of K326 showed that 584 metabolites were significantly different and there were 44 aroma-related metabolites, including alcohols, aldehydes, phenols, organic acids, etc. The analyzed aroma compounds consist of 37 known tobacco aroma substances, while 7 metabolites, previously not associated with tobacco aroma, have been identified as aroma substances in other food products. These findings suggest that these seven metabolites might may be potential tobacco aroma compounds. Further analysis showed that the content of phenols, alcohols, and aldehydes increased significantly after flue-curing, but the content of organic acids decreased. Furthermore, the analysis of KRK26 revealed a correlation between the quantity of aroma substances and the type of tobacco. These findings serve as a reference for enhancing the flue-curing process of K326 and optimizing the industrial production of cigarettes that use cured K326 tobacco leaves.
Impact of Entrepreneurial Orientation on MSME Performance: Mediating Role of Entrepreneurial Competency
Authors: Goyal Arpita , Mishra Uma Sankar 
Published: April 2023

Abstract
This study uses entrepreneurial competencies as a mediating element to explore the scope and pattern of influence of entrepreneurial orientation (EO) on micro, small and medium entrepreneur (MSME) business success. The study’s target population was small-scale business owners and employees from Rajasthan, India. A sample of 339 small companies was selected through the purposive sampling method. Data were gathered through a survey instrument designed given an appropriate theoretical context. The survey instrument was tested for its proper validity and reliability. Further, we used the structural equation modeling approach to test the hypotheses. Derived findings indicated that the direct impact of entrepreneurial orientation (EO) on firm performance was significant. Additionally, the relationship between EO and MSME performance was partially mediated by entrepreneurial competencies. The conceptual framework and findings offer the MSME sector entrepreneur new directions for positioning their product in customers’ minds and supporting the growth of an innovative and opportunistic mindset. The current research findings help to outperform the competition and take advantage of market opportunities. The organization must be able to correctly match what it delivers to the consumer with the needs and demands of the customer.
Study on the influence of dual-winding optimization design on the torque and suspension performance of bearingless motor
Authors: Qiu Hongbo , He Kun 
Published: April 2023

AbstractThe bearingless motor with dual-winding embedded in the stator can not only produce electromagnetic torque and can also produce suspension force to support the rotor suspension, and the design of the dual-winding will directly affect the torque and suspension performance of the motor. It is a complex problem of multi-objective optimization, multi-performance coupling, and multi-parameter collaborative optimization, which is great significance to improve the comprehensive performance of the motor. Firstly, in order to solve the problem of slot space ratio and turns design of dual-winding under the restriction of stator slot space and thermal loading, the calculation formulas of the electromagnetic torque and the suspension force are derived. The influence of dual-winding design on electromagnetic loading, thermal loading, torque and suspension performance are analyzed. The linear variation of electromagnetic torque with the slot space ratio of torque winding is obtained, and the influence of the dual-winding magnetic motive force on suspension force is clarified. Secondly, in order to obtain the dual-winding design scheme with the optimal torque and suspension performance, the performance parameters of the motor are calculated by finite element method and the influence of the slot space ratios of the torque winding on the torque and suspension performance is analyzed. Based on the coupling analysis of the electromagnetic torque and the suspension force in the case of different thermal loading distributions of dual-winding, the dual-winding optimal design of the bearingless motors is given. Finally, the suspension force of a prototype is tested by experiment.
A condition evaluation ensemble for power metering HPLC units within complex data scenarios
Authors: Jiyang Liu , Chenhao Sun , Zhuoran Xu , Yanzheng Liu , Zhengjie Sun , Shiqin Wang 
Published: April 2023

Abstract
The High-Speed Power Line Carrier Communication (HPLC) enables the connections among power metering devices in integrated energy systems, and thus their satisfying operations are indispensable for system reliabilities. In order to more precisely diagnose their conditions especially in real complex data scenes, a multi-model evaluation ensemble is proposed in this paper. Firstly, typical IoT application contexts of customer-side metering equipment are analyzed, thus the corresponding main impact factors along with their performance evaluation indices can be probed. Next, to handle the multi-source, heterogeneous, high-dimensional datasets during applications, the Kernel Independent Component Analysis (KICA) is established to diminish data dimensionalities, thus the individual weights of each index can be rated. On the other hand, the Component Importance Measure (CIM) model is built to differentiate the impact degree of each indicator on the overall IoT connection performance, where the influence of dissimilar index on the entire performance, rather than the proportion or frequency, will be directly assessed to determine their impact weights. Ergo, a comprehensive diagnosis can be achieved via these two-fold total weights accordingly. Finally, the feasibility and effectiveness of the proposed method can be verified by an empirical case study, which is conducive to further improving the accuracy and rationality of HPLC condition evaluations.
DinSAR coseismic deformation measurements of the Mw 8.3 Illapel earthquake (Chile)
Authors: Calvet Agustín , Balbarani Sebastián , Gende Mauricio 
Published: April 2023

Abstract
The beginning of radars goes back to the 1930s where its main boost was related to the second world war. Nowadays, the techniques associated with radars are focused around a vast variety of civil, geodetic, and military applications. The development of the synthetic aperture principle, in the 1950s and 1960s, gave birth to a lot of new applications, and together with the technological progress of the last decades, the technique of interferometry with synthetic aperture radar (SAR) data became one of the most powerful ones for sensing remotely, with high quality and a vast spatial coverage. We used Sentinel-1 data and the differential interferometry SAR (DinSAR) technique to map and measure the surface deformation related to the 2015 Mw 8.3 Illapel earthquake (Chile). We also validated the results, by analysing the temporal variation of coordinates acquired from global navigation satellite system observations and projecting them in the geometry of the SAR system. Using this application we prove the DinSAR technique to be useful and powerful for the observation and analysis of surface deformation caused by the release of stress during the Mw 8.3 Illapel earthquake. It proved to be an efficient tool to detect and map the surface deformation with high spatial resolution in an approximate area of 20,000 km2.
Hegel and Nietzsche on Self-Judgment, Self-Mastery, and the Right to One’s Life
Authors: Yigit Emir 
Published: April 2023

Abstract
Nietzsche’s views regarding suicide are usually interpreted as a response to Christian, Kantian, and Schopenhauerian ethics. Here, they are defended on the basis of his notion of life as an aesthetic phenomenon in order to provide extramoral responses to such challenges as the following: a) whether the self can deliver the right kind of judgment regarding her life, b) how suicide can be considered an empowerment of the will, and c) whether suicide can be considered an exercise of freedom by the subject who thereby cancels the very grounds and means for will and action. Reconstructed as a response to Hegel’s argument against suicide on the grounds that one is not the master of oneself and that one therefore lacks the proper means to judge one’s life, Nietzsche’s position provides the epistemic footing to ground an alternate notion of self-mastery as well as the necessary insight regarding one’s life. It is shown that this reading of Nietzsche’s argument is in alignment with his non-dualism and expressivist views regarding agency. Finally, a response is formulated to the socially-grounded arguments prohibiting suicide on the basis of this reading of Nietzsche’s position.
A brief review of the application of microextraction by packed sorbent for antibiotics analysis from biological, food, and environmental samples
Authors: Granados-Guzmán Graciela , Díaz-Hernández Mónica , Alvarez-Román Rocío , Cavazos-Rocha Norma , Portillo-Castillo Omar J. 
Published: April 2023

Abstract
Currently, sample preparation is the most laborious part of the analytical process, requiring the most time and being susceptible to the most errors. In this context, numerous investigations have focused on the miniaturization of these techniques to reduce work time, costs, and errors. In this regard, microextraction by packed sorbent (MEPS) is a simple, fast, and robust sample preparation technique suitable for easy automation in several analytical systems and is applied to a wide variety of samples. Antibiotics are among the most commonly used drugs; however, their extensive and inappropriate use has garnered significant attention in the environment, human health, and food safety. This brief review is intended to provide an overview of recently reported antibiotic extraction methods based on MEPS, with a special interest in those applied to the analysis of biological, environmental, and food samples. In addition, the sample pretreatment step before extraction by the MEPS device was highlighted, as was the description of the sample-related steps within the MEPS procedure, such as extraction, washing, and elution.
Kinetics of simultaneous degradation of brilliant green and methyl orange using biosynthesized high functional Ag nanoparticles
Authors: Ali Faisal , Safdar Anosha , Younas Umer , Sillanpaa Mika , Pervaiz Muhammad , Nazir Arif , Naeem Muhammad , Iqbal Munawar , Al-Kahtani Abdullah A. , Tighezza Ammar Mohamed 
Published: April 2023

Abstract
Nanoparticles synthesised using natural resources is a cost-effective and ecofriendly technique with a number of advantages. In current work, silver nanoparticles (AgNPs) have been synthesized using the extract of Fragaria ananassa seeds. The extract was used as a source of phytochemicals that can act as reducing and stabilizing agents. The characteristics of AgNPs were determined by UV/Visible, FTIR, SEM, XRD and Dynamic light scattering (DLS) techniques. The appearance of the distinctive absorption peak in UV-visible spectra at 430 nm confirmed the formation of AgNPs. The involvement of different bioactive functional groups with AgNPs was authenticated by FTIR studies. Particle size and morphology was confirmed by DLS, SEM and XRD analysis. The catalytic potential of AgNPs for the removal of poisonous organic dyes, brilliant green (BG) and methyl orange (MO) was also tested. Effect of different parameters including the catalyst concentration, dyes concentration and presence of different salts on the degradation of dyes was investigated. Nano-size and well-distributed nature of AgNPs, BG and MO dyes were degraded rapidly individually as well as simultaneously. The degradation process obeyed pseudo first order kinetics. Authors concluded that AgNPs synthesized using environment friendly and cost-effective method, can be used as a new tool to combat pollution caused by carcinogenic organic dyes.
Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome
Authors: Mathur Anukriti , Kay Callum , Xue Yansong , Pandey Abhimanu , Lee Jiwon , Jing Weidong , Enosi Tuipulotu Daniel , Lo Pilato Jordan , Feng Shouya , Ngo Chinh , Zhao Anyang , Shen Cheng , Rug Melanie , Miosge Lisa A , Atmosukarto Ines I , Price Jason D , Ali Sidra A , Gardiner Elizabeth E , Robertson Avril AB , Awad Milena M , Lyras Dena , Kaakoush Nadeem O , Man Si Ming 
Published: April 2023

AbstractInflammasome signaling is a central pillar of innate immunity triggering inflammation and cell death in response to microbes and danger signals. Here, we show that two virulence factors from the human bacterial pathogen Clostridium perfringens are nonredundant activators of the NLRP3 inflammasome in mice and humans. C. perfringens lecithinase (also known as phospolipase C) and C. perfringens perfringolysin O induce distinct mechanisms of activation. Lecithinase enters LAMP1+ vesicular structures and induces lysosomal membrane destabilization. Furthermore, lecithinase induces the release of the inflammasome‐dependent cytokines IL‐1β and IL‐18, and the induction of cell death independently of the pore‐forming proteins gasdermin D, MLKL and the cell death effector protein ninjurin‐1 or NINJ1. We also show that lecithinase triggers inflammation via the NLRP3 inflammasome in vivo and that pharmacological blockade of NLRP3 using MCC950 partially prevents lecithinase‐induced lethality. Together, these findings reveal that lecithinase activates an alternative pathway to induce inflammation during C. perfringens infection and that this mode of action can be similarly exploited for sensing by a single inflammasome.
Two cases of cardiomyopathy associated with phaeochromocytoma successfully managed with veno-arterial extracorporeal membrane oxygenation (V-A ECMO)
Authors: Fennell David , Miller Clare , Ludgate Stephen , Conneely John , O’Brien Serena , Conrick-Martin Ian , Hastings Jennifer , McQuaid Siobhán E 
Published: April 2023

Summary
Phaeochromocytoma, a rare neuroendocrine tumour of chromaffin cell origin, is characterised by catecholamine excess. Clinical presentation ranges from asymptomatic disease to life-threatening multiorgan dysfunction. Catecholamine-induced cardiomyopathy is a dreaded complication with high lethality. While there is lack of evidence-based guidelines for use of veno-arterial extracorporeal membrane oxygenation (V-A ECMO) in the management of this condition, limited to case reports and small case series, V-A ECMO has been reported as ‘bridge to recovery’ therapy, providing circulatory support in the initial period of stabilisation prior to surgery. We report on two patients presenting with catecholamine-induced cardiomyopathy and circulatory collapse who were successfully treated with V-A ECMO for 5 and 6 days, respectively, providing initial haemodynamic support. After stabilisation and introduction of alpha-blockade, both cases had favourable outcomes, with successful laparoscopic adrenalectomies on days 62 and 83 of admission, respectively. Our case reports provide further support for the use of V-A ECMO in the treatment of such gravely ill patients.

Learning points

Phaeochromocytoma should be considered in the diagnosis of patients presenting with acute cardiomyopathy.

Management of catecholamine-induced cardiomyopathy is complex and requires multidisciplinary specialist input.

Pre-operative management of phaeochromocytoma involves alpha-blockade; however, haemodynamic instability in the setting of cardiogenic shock can preclude alpha-blockade use.

Veno-arterial extracorporeal membrane oxygenation is a life-saving intervention which may be considered in cases of acute catecholamine-induced cardiomyopathy and cardiogenic shock in order to provide the required haemodynamic support in the initial phase of treatment, enabling the administration of traditional pharmacological agents, including alpha-blockade.
Reversibility in male idiopathic osteoporosis possible
Authors: Jamall Ijaz S , Ullery Michael C , Rocchietti March Massimiliano , Pignatti Elisa , Rochira Vincenzo , Brücher Björn L D M 
Published: April 2023

Summary
A 44-year-old athletic man presented in 2009 with severe low back pain. Dual-energy x-ray absorptiometry revealed severe osteoporosis; serum testosterone was 189 ng/dL while serum estradiol (E2) measured by liquid chromatography/mass spectrometry was 8 pg/mL. DNA was extracted and sequenced from a blood sample from the patient since his maternal first cousin also had low bone mass and both patients were screened for aromatase dysfunction by PCR analysis for the CYP19A1 gene, which encodes aromatase. No known pathologic mutations were observed in the coding exons, but novel single nucleotide polymorphisms were detected both in the proband and in his cousin. Treatment with topical testosterone started in August 2010. Over the next 8 years, testosterone dosage was varied and switched from topical gel to injections and maintained on depo-injections of testosterone at about 60 mg once per week. Re-examination in March 2012 included a brain MRI to exclude pituitary lesions; hyperparathyroidism was ruled out (normal serum parathyroid hormone, calcium, and calcium to phosphorous ratio) and celiac disease was excluded (negative transglutaminase antibodies). Follow-up in October 2018 showed improved bone mineral density of the lumbar spine by 29% and of the left femoral hip by 15% compared to baseline measurements. This reveals the importance of measuring serum E2 for making the correct diagnosis, as well as for monitoring a therapeutic effect. Herein, we propose treatment of male osteoporosis where serum E2 levels are below about 20 pg/mL with testosterone to reverse osteoporosis.

Learning points

Estrogen deficiency in the diagnosis of male idiopathic osteoporosis.

Importance of serum estradiol in male osteoporosis.

Role of polymorphisms in aromatase gene on bone health.

Reversal of osteoporosis.

Tailored testosterone treatment for bone health.
Activity and Recovery Among Youth With Concussion: A Meta-analysis
Authors: Chauhan Rochelle , Cheng Anika , Tsow Rebecca , Sakakibara Brodie M. , Babul Shelina , Schmidt Julia 
Published: April 2023

CONTEXTConcussions in youth are highly prevalent. Previously, rest was prescribed to prevent adverse outcomes; however, early return to activity is emerging to improve the recovery trajectory.OBJECTIVESTo evaluate the effectiveness of early return to physical and social activity interventions on recovery outcomes in youth with concussion.DATA SOURCESA systematic review was conducted up to October 2022.STUDY SELECTIONWe included randomized controlled trials (RCTs) and non-RCTs that reported effects of activity-based interventions on symptoms, quality-of-life (QoL), and return to preinjury activity levels in children and youth after a concussion.DATA EXTRACTIONThree authors independently extracted data on publication year and country, study setting and design, sample size, participant demographics, intervention, outcome(s), and author conclusion. Meta-analysis was conducted on appropriate RCTs.RESULTSTwenty-four studies were included in the final review, of which 10 were RCTs. There was a significant effect of activity interventions on symptom reporting (standardized mean difference, 0.39 [95% confidence interval, 0.15 to 0.63]; I2, 0%; P = .002). There was not a significant effect of activity-based interventions on QoL (mean difference, −0.91 [95% confidence interval, −7.76 to 5.94]; I2, 0%; P = .79). No meta-analysis was performed on return to preinjury activity levels because of insufficient number of RCTs conducted.LIMITATIONSOne outcome was excluded from the meta-analysis. Interventions emphasizing social activity were lacking.CONCLUSIONSFindings indicate that activity-based interventions may significantly improve concussion symptoms. There is insufficient data to understand the effect of activity-based intervention on QoL and return to preinjury activity levels.
Li-Fi technology based long range free-space communication data transmit system evaluation
Authors: Faruq Omar , Shahriar Rahman Kazi Rubaiyat , Jahan Nusrat , Rokoni Sakib , Rabeya Mosa 
Published: April 2023

AbstractThe most flexible and reliable technological system is Wi-Fi, which is made possible by a wireless connection that transmits data using radio frequencies. Wi-Fi networks, however, encounter numerous issues related to power supply, availability, efficiency, and security as a result of the various access points. While relational waves describe the medical device, Wi-Fi radios produce radio waves that are very dangerous for patients. This document offers line-of-sight communication between the transmitter and receiver using LED technology. Li-Fi technology is a method that transmits audio data using LED light, which is faster and more efficient than Wi-Fi. Since it is practically ubiquitous, light can be used for communication as well. A cutting-edge technology called optical communication includes a subset called light fidelity. By sending out visible light, the Li-Fi device enables wireless intranet communication. This paper is an in-depth study and analysis of Light Fidelity (Li-Fi), a novel technology that transmits data at high speeds over a wide spectrum by using light as a medium of transmission. The research fields that are pertinent to Li-Fi networks are thoroughly analyzed and categorized in this paper: high speed data transmission, receiving, sharing, broadcasting through light in free space optical communication system by Li-Fi technology. In this paper, we followed some methods and developed a unique method to develop this study: VLC, OOK, a Lambertian discharge mechanism, LOS, NLOS, or a CMOS optical receiver. The proposed model tested transmits and receives audio, video, and other data, which is very high-rated and near the 2 GB/s range.
Listeriosis myeloma multiplexben
Authors: Sánta Hermina , Müller Zsófia , Dömötör Mária , Berzy Klára , Sashalmi Soma , Gulyás Ádám , Bátai Árpád 
Published: April 2023

A listeriosis fakultatívan intracelluláris, Gram-pozitív baktérium által okozott, fekoorálisan, fertőzött élelmiszerrel terjedő fertőzés, mely elsősorban immunszupprimált betegeknél, időseknél és várandósoknál okoz súlyos betegséget.Egy myeloma multiplex miatt második vonalban bortezomib, lenalidomide és dexamethason kezelésben részesült betegünk esete kapcsán hívnánk fel a figyelmet erre a ritka, megfelelő diagnosztika és terápia nélkül jelentős halálozással járó kórképre.Betegünk otthonában tévedésből két héten át napi 20 mg dexamethasont szedett. Kórházi felvételekor pár napja spontán szűnő hasmenésre panaszkodott. Észlelésünk második napján betegünk aluszékonnyá vált, fejfájást jelzett, lázassá vált. Tenyésztésekre történő mintavételt követően empirikusan, ismert penicillinallergia miatt, meropenemterápia indult. Hemokultúrából Listeria monocytogenes tenyészett ki. A 14 napig alkalmazott antibiotikus terápia hatására betegünk állapota fokozatosan javult, majd emittálhatóvá vált. Szövődményt nem észleltünk.