bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tobacco purchasing in Australia during regular tax increases: findings from the International Tobacco Control Policy Evaluation Project
Authors: Cho Ara , Scollo Michelle , Chan Gary , Driezen Pete , Hyland Andrew , Shang Ce , Gartner Coral E 
Published: August 2023

ObjectiveWe examined Australian tobacco purchasing trends, the average self-reported price paid within each purchase type and the association between type of tobacco product purchased and participant characteristics, including quit intentions, between 2007 and 2020.MethodsWe analysed data collected from adults who smoked factory-made and/or roll-your-own (RYO) cigarettes in nine waves (2007–2020) of the International Tobacco Control Policy Evaluation Project Australia Survey (nsample=5452, nobservations=11 534). The main outcome measures were type of tobacco products purchased: RYO, carton, pack or pouch size and brand segment. Logistic regression, fit using generalised estimating equations, was estimated the association between the outcome and participant characteristics.ResultsThe reported price-minimising purchasing patterns increased from 2007 to 2020: any RYO (23.8–43.9%), large-sized pack (2007: 24.0% to 2016: 34.3%); shifting from large-sized to small-sized packs (2020: 37.7%), and economy brand (2007: 37.2% to 2020: 59.3%); shifting from large (2007: 55.8%) to small economy packs (2014: 15.3% to 2020: 48.1%). Individuals with a lower income, a higher nicotine dependence level and no quit intention were more likely to purchase RYO and large-sized packs.ConclusionRYO, large-sized packs and products with a low upfront cost (eg, small RYO pouches and small-sized economy brand packs) may appeal to people on low incomes. Australia’s diverse tobacco pack and pouch sizes allow the tobacco industry to influence tobacco purchases. Standardising pack and pouch sizes may reduce some price-related marketing and especially benefit people who have a low income, are highly addicted and have no quit intention.
Evolution of the dynamics of Airdrop Glacier, western Axel Heiberg Island, over a seven-decade-long advance
Authors: Lauzon Benoît , Copland Luke , Van Wychen Wesley , Kochtitzky William , McNabb Robert 
Published: August 2023

Various remotely sensed data, including historical aerial photographs, declassified intelligence satellite photographs, optical satellite imagery, and synthetic aperture radar data, were used to undertake the first comprehensive reconstruction of the dynamics of Airdrop Glacier on Axel Heiberg Island, Nunavut. Observations show a continuous terminus advance totalling ∼6 km since 1950 and notably less variability in its surface velocities in comparison to adjacent Iceberg Glacier. This advance is concurrent with relatively high flow rates over its entire surface, resulting in significant thickening near the terminus and thinning at higher elevations. Velocities have more than halved from the mid-2000s to 2021, but without any definitive evidence of previous flow instabilities, we cannot confirm whether Airdrop's behaviour is cyclic in nature and therefore characteristic of a surge. Instead, Airdrop Glacier could be experiencing a delayed response to the positive mass balance conditions of the Little Ice Age, which could also explain the advance of other nearby glaciers. Its recent slowdown could then be indicative of a gradual adjustment to recent climatic conditions. This study highlights the need for comprehensive studies of glacier dynamics in the Canadian Arctic to improve our understanding of the factors triggering dynamic instabilities and causing the observed variety of behaviours.
Pionic and radiative transitions from $$T_{c\bar{s}0}^+(2900)$$ to $$D_{s1}^+(2460)$$ as a probe of the structure of $$D_{s1}^+(2460)$$
Authors: Yue Zi-Li , Xiao Cheng-Jian , Chen Dian-Yong 
Published: August 2023

AbstractIn this work, we evaluated the widths of the pionic and radiative transitions from the $$T_{c\bar{s}0}^{+}(2900)$$

T

c

s

¯

0

+

(
2900
)

to the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

in the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

molecular frame and the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

charmed-strange meson frame. Our estimations demonstrate that the transition widths in the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

molecular frame are much larger than those in the the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

charmed-strange meson frame. Specifically, the ratio of the widths of $$\Gamma (T_{c\bar{s}0}^{+}(2900)\rightarrow D_{s1}^{+} \pi ^{0})$$

Γ
(

T

c

s

¯

0

+

(
2900
)

→

D

s
1

+

π
0

)

and $$\Gamma (T_{c\bar{s}0}^{+}(2900)\rightarrow D^{+(0)}K^{0(+)})$$

Γ
(

T

c

s

¯

0

+

(
2900
)

→

D

+
(
0
)

K

0
(
+
)

)

is estimated to be around 0.1 in the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

charmed-strange meson frame, whereas the lower limit of this ratio is 0.67 in the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

molecular frame. Thus, the aforementioned ratio could be employed as a tool for testing the nature of the $$D_{s1}^{+}(2460)$$

D

s
1

+

(
2460
)

.
Possible Factors Related to Mortality of Pregnant Women with COVID-19: A Machine Learning Approach
Authors: Tran Thuy Thi-Thanh , Tran Huy Phuong , Vu Sang Ngoc-Thanh , Tran Tam Thi-Ngoc , Nguyen Thoai Ngoc , Ho Nuong Thi-Xuan , Pham Linh Thi-My , Pham Bao The , Hoang Tuyet Thi-Diem 
Published: August 2023

Background: The COVID-19 pandemic has affected people of all ages and backgrounds, but pregnant women are a particularly vulnerable group. They are at increased risk of severe illness and death from COVID-19, yet there is limited and conflicting data about the factors that contribute to mortality in this population. In this study, we sought to use machine learning (ML) to predict the possible factors associated with mortality in pregnant women with COVID-19. Methods: We collected data from a large cohort of pregnant women who had been diagnosed with COVID-19 at Hung Vuong Hospital. We included a range of demographic, clinical, and laboratory variables in our analysis, such as age, gestational age, comorbidities, symptoms, and laboratory test results. Our goal was to identify the critical factors that could be used to predict mortality in this vulnerable population. We applied several ML models and analyzed the results to determine the most useful predictors. Results: We analyzed a cohort of 550 pregnant women diagnosed with COVID-19, comprising 525 survivors and 25 deaths. Using ML algorithms, we identified key clinical and patient factors that correlated with mortality risk, such as infection severity, pulse rate, breathing patterns, SpO2 levels, rapid diagnostic tests, internal pathology, breathing difficulties, and changes in consciousness. Additionally, several medical test factors were found to be significant, including white blood cells, neutrophils, platelets, C-reactive protein (CRP), procalcitonin, and chest X-ray abnormalities. Our analysis revealed that the Gaussian Naive Bayes (NB) model was the most accurate, with an AUC score of 0.79, demonstrating its potential as a valuable tool for identifying high-risk patients. Conclusions: Our results suggest that the available data can capture the relationship between COVID-19 symptoms and mortality in pregnant women. More studies are needed to improve the accuracy and generalizability of models for predicting mortality risk in this population.
FOXO1 Inhibition Generates Potent Nonactivated CAR T Cells against Solid Tumors
Authors: Marchais Maude , Simula Luca , Phayanouvong Mélanie , Mami-Chouaib Fathia , Bismuth Georges , Decroocq Justine , Bouscary Didier , Dutrieux Jacques , Mangeney Marianne 
Published: August 2023

Abstract
Chimeric antigen receptor (CAR) T cells have shown promising results in the treatment of B-cell malignancies. Despite the successes, challenges remain. One of them directly involves the CAR T-cell manufacturing process and especially the ex vivo activation phase. While this is required to allow infection and expansion, ex vivo activation dampens the antitumor potential of CAR T cells. Optimizing the nature of the T cells harboring the CAR is a strategy to address this obstacle and has the potential to improve CAR T-cell therapy, including for solid tumors. Here, we describe a protocol to create CAR T cells without ex vivo preactivation by inhibiting the transcription factor FOXO1 (CAR TAS cells). This approach made T cells directly permissive to lentiviral infection, allowing CAR expression, with enhanced antitumor functions. FOXO1 inhibition in primary T cells (TAS cells) correlated with acquisition of a stem cell memory phenotype, high levels of granzyme B, and increased production of TNFα. TAS cells displayed enhanced proliferative and cytotoxic capacities as well as improved migratory properties. In vivo experiments showed that CAR TAS cells were more efficient at controlling solid tumor growth than classical CAR T cells. The production of CAR TAS from patients’ cells confirmed the feasibility of the protocol in clinic.
GAMBARAN KEPATUHAN BEROBAT PASIEN RETINOPATI DIABETIK DI PMN RS MATA CICENDO 2021–2022
Authors: Naqiya Wafa , Virgana Rova , Kartasasmita Arief Sjamsulaksan 
Published: August 2023

Pendahuluan: Retinopati diabetik (RD) merupakan komplikasi mikrovaskular penyakit diabetes melitus dengan angka pertumbuhan tinggi. Kepatuhan melakukan pemeriksaan rutin dan menjalankan tindakan khusus dapat mencegah progresivitas penyakit ini. Namun, penelitian mengenai gambaran kepatuhan berobat pasien retinopati diabetik belum pernah dilakukan di Indonesia. Penelitian ini bertujuan untuk mengetahui gambaran kepatuhan berobat pasien retinopati diabetik di PMN RS Mata Cicendo.
Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan metode cross sectional, menggunakan data sekunder dari EMR, dan dilakukan pada periode 1 Januari 2021–31 Desember 2022 di PMN RS Mata Cicendo. Kepatuhan dinilai berdasarkan kepatuhan menjalankan masa awal pengobatan dan diukur melalui data tanggal registrasi, tindakan, dan perencanaan. Hasil penilaian kepatuhan kemudian dikelompokkan berdasarkan derajat retinopati diabetik, tipe diabetes melitus, jenis tindakan, jenis kelamin, usia, pekerjaan, pendidikan terakhir, dan domisili.
Hasil: Penelitian ini melibatkan 887 rekam medis dan 533 (60,1%) di antaranya dikategorikan patuh. Data menunjukkan persentase kepatuhan >60% pada pasien derajat berat seperti Proliverative Diabetic Retinopathy (61,6%); berjenis kelamin perempuan (60,2%); berusia muda kelompok 25–34 tahun (77,4%); berdomisili di Bandung Raya (64,4%) atau luar Jawa Barat (63,5%); berpendidikan terakhir tinggi sarjana muda (68,9%); bekerja sebagai pegawai swasta (67,1%), pengajar (72,7%), wiraswasta (61,3%), atau pensiunan (66,7%); memiliki tipe diabetes melitus terspesifikasi non-insulin dependent (64,2%) atau insulin dependent (80,9%); serta mendapat rekomendasi tindakan laser (64,1%).
Kesimpulan: Secara umum kepatuhan berobat pasien retinopati diabetik di PMN RS Mata Cicendo sudah mencapai >60%. Kepatuhan pasien kontrol dengan jangka waktu menengah (1–3 bulan), panjang (>6 bulan) masih harus ditingkatkan.
Secretory Carcinoma of Breast: A Population-Based Study
Authors: Sanli Ahmet Necati , Tekcan Sanli Deniz Esin , Altundag M. Kadri , Aydogan Fatih 
Published: August 2023

Aim In this study, it was aimed to evaluate the characteristic features and survival of secretory carcinoma of the breast (SCB), which is one of the rare malignant tumors of the breast. Methods Data of patients with histopathological diagnosis of SCB between 2010 and 2019 were extracted from the SEER database. These patients were evaluated in terms of age, race, molecular subtype, grade, estrogen receptor (ER), progesterone receptor (PR), HER2 receptor, TNM stage, surgical status, chemotherapy and radiotherapy treatment. Overall survival (OS) and breast cancer-specific survival (BCSS) of the whole population and subgroups [in terms of surgery procedure (mastectomy/breast-conserving surgery), and hormone receptor status (positive/negative)] were analyzed. Results 70 patients were included in the study. The mean age was 57 years (range 2-82). 32.9% of the patients were diagnosed under the age of 50. 97.1% of the patients were female; 2.9% were male. The vast majority of patients were white race (81.4%). Although the rates of localization were higher in the upper outer quadrant (31.4%), centrally located tumors (18.5%) were also quite common. The most frequently detected molecular subtype was hormone positive/HER2 negative. All patients were non-metastatic, 81.4% of patients did not have lymph node metastases, and most of the patients were stage IA. Median follow-up was 37 months (range 0-118 months). Considering all patients, OS was 76.3%, 5-year OS was 91.8%, and BCSS was 88%, 5-year BCSS was 97.8%. There was no statistically significant difference in OS and BCSS according to subgroups ( P > .01). Conclusion SCB, a rare histopathologic type, has high OS and BCSS rates.
Perinatal depression: The use of the Edinburgh Postnatal Depression Scale to derive clinical subtypes
Authors: Galbally Megan , Watson Stuart J , Boyce Philip , Howard Louise , Herrman Helen 
Published: August 2023

Background: Predicting the course and complications of perinatal depression through the identification of clinical subtypes has been previously undertaken using the Edinburgh Postnatal Depression Scale and has the potential to improve the precision of care and improve outcomes for women and their children. Methods: Edinburgh Postnatal Depression Scale scores were collected twice in pregnancy and twice in the postpartum in a sample of 360 women who met diagnostic criteria for perinatal depression using the Structured Clinical Interview for DSM disorder. These data were used to compare with previous, though conflicting, evidence from cross-sectional studies and extend this by undertaking longitudinal measurement invariance modelling to test the structural validity across the perinatal period. Latent profile and transition modelling was used to identify distinct subtypes of women and assess the utility of these subtypes and transition profiles to predict clinically meaningful outcomes. Results: Although our data supported one of the previously reported three-factor Edinburgh Postnatal Depression Scale structures used to compute subfactor totals for depressed mood, anxiety and anhedonia at both early pregnancy and 6 months postpartum, there was little value in using these Edinburgh Postnatal Depression Scale subfactor scores to identify subtypes predictive of clinically meaningful postpartum symptom subtypes, or of general health, pregnancy and neonatal outcomes. Conclusion: Our study does not support the use of the Edinburgh Postnatal Depression Scale to distinguish perinatal depressive subtypes for the purposes of predicting course and complications associated with perinatal depression. However, the results give guidance on alternative ways to study the value of personalised management in improved outcomes for women living with or at risk for perinatal depression.
Management of cluster headache: Treatments and their mechanisms
Authors: Peng Kuan-Po , Burish Mark J. 
Published: August 2023

Background The management of cluster headache is similar to that of other primary headache disorders and can be broadly divided into acute and preventive treatments. Acute treatments for cluster headache are primarily delivered via rapid, non-oral routes (such as inhalation, nasal, or subcutaneous) while preventives include a variety of unrelated treatments such as corticosteroids, verapamil, and galcanezumab. Neuromodulation is becoming an increasingly popular option, both non-invasively such as vagus nerve stimulation when medical treatment is contraindicated or side effects are intolerable, and invasively such as occipital nerve stimulation when medical treatment is ineffective. Clinically, this collection of treatment types provides a range of options for the informed clinician. Scientifically, this collection provides important insights into disease mechanisms. Methods Two authors performed independent narrative reviews of the literature on guideline recommendations, clinical trials, real-world data, and mechanistic studies. Results Cluster headache is treated with acute treatments, bridge treatments, and preventive treatments. Common first-line treatments include subcutaneous sumatriptan and high-flow oxygen as acute treatments, corticosteroids (oral or suboccipital injections) as bridge treatments, and verapamil as a preventive treatment. Some newer acute (non-invasive vagus nerve stimulation) and preventive (galcanezumab) treatments have excellent clinical trial data for episodic cluster headache, while other newer treatments (occipital nerve stimulation) have been specifically tested in treatment-refractory chronic cluster headache. Most treatments are suspected to act on the trigeminovascular system, the autonomic system, or the hypothalamus. Conclusions The first-line treatments have not changed in recent years, but new treatments have provided additional options for patients.
Effects of different amine-functionalized graphene oxide on the mechanical and thermal properties of polyimide composites
Authors: Zhang Yuxia , Liu Haojie , Liu Menghan , Ma Xiaofan , Shi Haifeng 
Published: August 2023

The utilization of functionalized graphene oxide as nanofillers has attracted significant attention in the development of high-performance composite materials. In this study, amine-functionalized graphene oxide (AFGO) by different amines, including p-phenylenediamine- (PPD-GO) and 4, 4’-diaminodiphenyl ether (ODA-GO), respectively, was prepared and used to synthesize a series of polyimide (PI) composite membranes via in situ polymerization method. The PPD-GO/PI and ODA-GO/PI composite membranes exhibited much higher mechanical and thermal properties than that of neat PI, owing to the diverse interfacial interaction and the surface architecture behavior. Compared to neat PI, the tensile strengths were enhanced 14.6% and 14.5%, the tensile modulus were enhanced 26.9% and 23.2%, and the Tg increased by 9°C and 17.5°C of the PI composite membrane containing 0.3 wt% PPD-GO or ODA-GO, respectively. This study provides a guidance for the development of high-performance PI composite materials through the regulated interfacial structure via the moderate chain length.
The outcomes of penile prosthesis in neurologic patients: a multicentric retrospective series
Authors: Falcone Marco , Capogrosso Paolo , Cirigliano Lorenzo , Geretto Paolo , Preto Mirko , Timpano Massimiliano , Ceruti Carlo , Peretti Federica , Ferro Ilaria , Plamadeala Natalia , Dehò Federico , Bettocchi Carlo , Manfredi Celeste , Spirito Lorenzo , Palmieri Alessandro , Manassero Alberto , Blecher Gideon , Gontero Paolo 
Published: August 2023

Introduction: Neurological disease is a known entity for causing erectile dysfunction (ED). Pharmacological therapies are not always effective these patients – penile prosthesis implant (PPI) is an established surgical treatment option. For a variety of reasons, neurological patients may experience differing outcomes of PPI compared to those whose ED arises from other causes. We investigated outcomes of PPI in neurological patients using the Italian multi-institutional national registry of penile prostheses [Italian Nationwide Systematic Inventarization of Surgical Treatment for ED (INSIST-ED)]. Methods: Patients undergoing PPI were investigated via the INSIST-ED registry, from 2014 to 2021. Data were prospectively recorded by 45 surgeons on a dedicated website ( www.registro.andrologiaitaliana.it ) and reviewed by a data manager. We subselected patients with neurological disease undergoing PPI for ED, and these patients were reviewed at 3, 6, and 12 months, and annually thereafter. Postoperative complications and functional outcomes were evaluated through validated questionnaires [International Index of Erectile Function-5 (IIEF-5), Sexual Encounter Profile 2–3, and Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS)]. A nonvalidated questionnaire was administered to assess patient satisfaction. Results: A total of 33 patients were included with a median age of 49 [interquartile range (IQR) 41–55]. Median follow-up was 83 months (IQR 67–99.5). A penoscrotal approach for PPI was performed in most cases (90.9%), while infrapubic was used in three cases (9.1%). Inflatable and malleable devices were implanted in 30 (90.9%) and 3 cases (9.1%), respectively. Intraoperative complications occurred in one case (3%). Early postoperative complications (<90 days) were observed in three cases (9.1%): two wound dehiscence (Clavien-Dindo G1 and G3a respectively) and one device infection requiring prosthesis explant (Clavien-Dindo G3a). Mechanical failures of inflatable devices were not observed during the follow-up period. Median IIEF-5 before surgery was 8 (IQR 7–9). At the latest follow-up, IIEF-5 was 22 (IQR 19–23.5), and median EDITS was 79 (IQR 64–88). A total of 28 patients (84.8%) self-reported to be fully satisfied with the PPI. Conclusion: Although PPI in the neurological population has been historically considered to be at increased risk, in our study, PPI complications and infections rates in this cohort did not differ from general population.
Mitigating casualty risks from primary fragmentation hazards
Authors: Qin Hao , Stewart Mark G 
Published: August 2023

Primary fragmentation from detonation of high-explosive metal-cased munitions imposes significant risks to the safety of related personnel and the public. Barricades or other protective structures are commonly used to stop fragments and reduce casualty risks caused by detonated munitions when a sufficient safety distance cannot be guaranteed. This study aims to provide decision support for the positioning of barricades that can reasonably mitigate primary fragmentation hazards from the detonation of large calibre munitions using a probabilistic risk assessment approach. This approach enables a stochastic characterization of fragment ejections, stacking effects, fragment trajectories, human vulnerability and fragment hazard reduction by barricade. In a case study, the assessments of casualty risks and effectiveness of barricades were conducted for a single and a pallet of 155 mm projectiles. It was found that barricades with heights exceeding the height of munitions can significantly reduce the hazardous fragment densities and casualty risks beyond the barricade. The benefit of increasing the barricade height becomes marginal when it exceeds the height of munitions.