bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the secret codes in N7‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases
Authors: Fang Huan , He Jing , Du Dan , Wang Xue , Xu Xinyu , Lu Linping , Zhou Yefan , Wen Yangyang , He Fucheng , Li Yingxia , Wen Hongtao , Zhou Mingxia 
Published: February 2025

AbstractN7‐methylguanosine (m7G) is one of the most prevalent post‐transcriptional modifications of RNA and plays a critical role in RNA translation and stability. As a pivotal m7G regulator, methyltransferase‐like 1 (METTL1) is responsible for methyl group transfer during the progression of m7G modification and contributes to the structure and functional regulation of RNA. Accumulating evidence in recent years has revealed that METTL1 plays key roles in various diseases depending on its m7G RNA methyltransferase activity. Elevated levels of METTL1 are typically associated with disease development and adverse consequences. In contrast, METTL1 may act as a disease suppressor in several disorders. While the roles of m7G modifications in disease have been extensively reviewed, the critical functions of METTL1 in various types of disease and the potential targeting of METTL1 for disease treatment have not yet been highlighted. This review describes the various biological functions of METTL1, summarises recent advances in understanding its pathogenic and disease‐suppressive functions and discusses the underlying molecular mechanisms. Given that METTL1 can promote or inhibit disease processes, the possibility of applying METTL1 inhibitors and agonists is further discussed, with the goal of providing novel insights for future disease diagnosis and potential intervention targets.Key points
METTL1‐mediated m7G modification is crucial for various biological processes, including RNA stability, maturation and translation.
METTL1 has emerged as a critical epigenetic modulator in human illnesses, with its dysregulated expression correlating with multiple diseases progression and presenting opportunities for both diagnostic biomarker development and molecular‐targeted therapy.
Enormous knowledge gaps persist regarding context‐dependent regulatory networks of METTL1 and dynamic m7G modification patterns, necessitating mechanistic interrogation to bridge basic research with clinical translation in precision medicine.
Qiviut Trace and Macro Element Profile Reflects Muskox Population Trends
Authors: Dickinson Eleanor R. , Mosbacher Jesper Bruun , Arnison Colleen , Beckmen Kimberlee , Côté Steeve D. , Di Francesco Juliette , Hansson Sophia V. , Jahromi Elham Z. , Kinniburgh David W. , Le Roux Gäel , Leclerc Lisa‐Marie , Mavrot Fabien , Schmidt Niels M. , Suitor Michael J. , Taillon Joëlle , Tomaselli Matilde , Kutz Susan J. 
Published: February 2025

ABSTRACTUnderstanding the drivers influencing ungulate population dynamics is crucial for developing conservation and management strategies to support wildlife health. Trace and macro elements are vital for ungulate growth, reproduction and survival. Thus, the trajectory of wildlife populations may be associated with element imbalances. Element concentrations can be measured in hair, an increasingly recognised bio‐monitoring tool. However, a better understanding of the relevance for wild ungulate population dynamics is needed. This study aimed to assess if element profiles in hair reflected the population trajectory of a keystone Arctic ungulate, muskox Ovibos moschatus, and whether benchmarks could be defined for element concentrations to assess population status. We measured qiviut (hair) element concentrations of 11 muskox populations ranging across northern America, including Greenland, and evaluated the association between element concentrations and different population trajectories. Seven trace and macro elements differentiated increasing populations from declining and stable populations using linear discriminant analysis. In general, copper, selenium, iron, manganese and cobalt tended to be at higher concentrations in increasing populations, whereas zinc and calcium were generally at lower concentrations in these populations, though variations were observed among populations. Benchmarks were defined for copper, selenium and iron, indicating populations were more likely to decline below a threshold concentration of these elements (‘limit’) and increase above a threshold concentration (‘target’). ‘Limit’ benchmarks were defined for zinc and calcium where populations were more likely to be increasing below this threshold value. Hair element profiles are a useful indicator of population trajectory in wild ungulate populations. Identified benchmarks can be used to assess population status, complementing ongoing but irregular and expensive monitoring efforts like population surveys, while trace element concentrations can provide insights into the mechanisms driving population change. Hair samples can easily be collected non‐invasively or alongside other monitoring activities, enhancing proactive wildlife management and conservation.
Beat the heat: Movements of a cold‐adapted ungulate during a record‐breaking heat wave
Authors: Sheppard Aidan C. , Hollik Emily Z. , Hecker Lee J. , Jung Thomas S. , Edwards Mark A. , Nielsen Scott E. 
Published: February 2025

AbstractThe frequency and severity of extreme weather events such as heat waves are increasing globally, revealing ecological responses that provide valuable insights toward the conservation of species in a changing climate. In this study, we utilized data from two populations of GPS‐collared female wood bison (Bison bison athabascae) in the boreal forest of northwestern Canada to investigate their movement behaviors in response to the 2021 Western North American Heat Wave. Using generalized additive mixed‐effect models and a model selection framework, we identified a behavioral temperature threshold for wood bison at 21°C. Above this threshold, movement rates decreased from ~100 m/h at 21°C to a low of ~25 m/h at 39°C (150% decrease; −9%/°C). Extreme heat also contributed to changes in diurnal movement patterns, reducing wood bison movement rates and shifting the timing of peak activity from midday to early morning. These findings highlight the behavioral adaptations of female wood bison and underscore the need to understand the behavioral and physiological responses of cold‐adapted mammals to extreme weather events. Subsequent effects of thermoregulatory behavior may impact individual fitness and population viability, particularly at high latitudes where cold‐adapted species are increasingly exposed to severe weather resulting from anthropogenic climate change.
Uncovering the mechanisms underpinning divergent environmental change impacts on biodiversity and ecosystem functioning
Authors: Cadotte Marc W. , Tatsumi Shinichi 
Published: February 2025

AbstractEnvironmental change drivers (ECDs) impact ecological communities in various ways, from enrichment that increases species' performance and abundance, to stressors that reduce their reproduction and growth. These effects can affect species coexistence as well as impact ecosystem functioning and the relationship between biodiversity and ecosystem function (BEF). Predicting the impact of ECDs on communities and BEF relationships requires understanding how ECDs affect fundamental population parameters, including intrinsic rate of increase (r), carrying capacity (K), and interspecific interactions (). Here, we use numerical simulations based on theoretical models to show the explicit links between these parameters and the nature of BEF relationships. Depending on the mean and variance of the effects of ECDs on community members, BEF relationships increase or decrease in both their intercept and slope. We further derive hypotheses about how BEF relationships will be affected by multiple ECDs or when we consider multiple ecosystem functions. Our simple approach to understanding how ECDs affect BEF relationships provides a robust framework to explain why disparate studies and meta‐analyses come to opposing conclusions about resilience or sensitivity of BEF relationships to anthropogenic influences. We show that modeling approaches offer a generalized and predictive understanding to guide biodiversity conservation, restoration, and green infrastructure design under environmental change.
Tracing the Path of Knowledge on “Environmental Governance Processes” for Theory‐Building
Authors: Wood Liza , Vantaggiato Francesca Pia , Scott Tyler 
Published: February 2025

ABSTRACTThe vast range of environmental governance case studies makes one thing clear: social processes are at the heart of environmental problems—and solutions. But fragmentation in how different contributions define and study environmental governance processes prevents us from drawing lessons from the field. What is the extent of knowledge cumulation in the field, and what gaps remain unfilled in this literature? We address these questions by analyzing the bibliometric citation network of English language academic research focused on environmental governance processes. We identify eight clusters of research, where four highly cited “poles” stand out: (1) social‐ecological systems, (2) collaborative governance, (3) global environmental governance, and (4) political ecology. We identify four organizing concepts that are common to all clusters (scale, the importance of social outcomes, consideration of the environment, and the role of government), but with limited shared understandings of them. The field is wider than it is deep, limiting our ability to narrow down on a few overarching theoretical statements. We argue that environmental governance needs to link up with the environmental politics literature to be able address two important roadblocks in environmental governance processes: power asymmetries and trade‐offs of environmental decisions.
Institutional Design of Collaborative Water Governance: The River Chief System in China
Authors: Zhou Xiaomeng , Lin Yanliu , Hooimeijer Pieter , Monstadt Jochen 
Published: February 2025

ABSTRACTCollaborative governance has been increasingly applied in the field of water governance. However, this approach is often criticized for overlooking the political nature of water governance and the necessity of collaboration across multiple dimensions. The river chief system (RCS) in China represents a collaborative water governance approach designed to address collaboration challenges in Chinese water governance sector and ultimately combat its severe river pollution. This study develops a conceptual framework to analyze the institutional design of the RCS and examine its effectiveness in structuring vertical, horizontal, and territorial collaborations in local water governance. Taking the RCS in Xiamen as a case study, we find that public entities predominantly engage in collaborative initiatives mandated by higher‐level authorities, while collaborations between state and nonstate actors mainly focus on information collection and public environmental education. The collaborative processes under the RCS are characterized by the unchallenged authority of political leaders, exclusive decision‐making mechanisms, restricted information flows, implicit pay‐off structures, and limited involvement of nonstate actors. Consequently, the institutional design of the RCS falls short in fostering effective multidimensional collaboration among diverse actors. This study contributes to the literature on collaborative governance by offering insights into the institutional design of collaborative water governance within an authoritarian context and sheds lights on China's recent reforms of environmental governance.
Open Science Practices Among Evaluators: A Survey of AEA Members
Authors: Linnell Dana J. , Tilton Zach 
Published: February 2025

ABSTRACTThis study investigates the extent to which evaluators are aware of, understand, and use open science practices in their evaluation work. Members of the American Evaluation Association were surveyed to gather insights on their open science practices, including the sharing of evaluation plans, materials, data, and reports. The study also explored the facilitators and barriers to adopting open science, the alignment of these practices with professional evaluation standards, and the relevance of the replication crisis to evaluation. While some evaluators are sharing evaluation products—primarily reports—many report limited knowledge of and perceived importance of open science. Significant barriers hinder the sharing of evaluation products, such as concerns about confidentiality, contractual and funder restrictions, and fears of reputational harm or criticism. Additionally, evaluators’ understanding of open science may differ from that of established open science practitioners, highlighting opportunities for the evaluation field to further explore the potential benefits of open science practices. The survey, data, and preprint for this project can be found on the Open Science Framework at https://osf.io/r2sh7/.
Analysis of the Thermal Decomposition and Flammability of Polyurethane Materials Used in Building Insulation and in the Automotive Industry
Authors: Mizera Kamila , Sałasińska Kamila , Borucka Monika , Przybysz Jan , Gajek Agnieszka 
Published: February 2025

ABSTRACTThe development of technology and newer requirements for materials leads to an increase in their production and storage. In the past, serious fires have occurred in public buildings, residential buildings, industrial halls, and warehouses where plastics were used or produced, resulting in disastrous consequences for the environment and human health. For this reason, it is important to examine the risks to people and the environment that arise during a fire in places where these materials are located and stored. Polyurethane foams (PUF) used in building insulation and the automotive industry have been analyzed to determine their flammability and smoke emission during combustion. The thermal stability of PUFs was assessed using simultaneous thermal analysis (STA). Released gases were identified using STA combined with FT‐IR (STA/FT‐IR). Fire resistance and smoke emission during combustion were evaluated using cone calorimetry and a smoke chamber. Differences in thermal decomposition and combustion characteristics, including smoke release, were observed. The combustion of semi‐rigid foam was accompanied by the lowest total smoke release and the lowest total heat release. However, the combustion of flexible foam was characterized by the highest amount of smoke and a high rate of heat release, despite only a 5% weight loss at the highest temperature. In the case of rigid foam, a large residue in the form of a carbonized layer was observed.
Attitudes and Preferences Towards Screening for Dementia From the Perspectives of Healthcare Professionals: An Updated Systematic Review
Authors: Mc Ardle Ríona , Dsouza Abigail , Hagan Alexander , Al‐Oraibi Amani , Hanjari Matilda , Stephan Blossom C. M. , Brayne Carol , Lafortune Louise , Bains Manpreet , Qureshi Nadeem , Robinson Louise 
Published: February 2025

ABSTRACTObjectivesApproximately 55 million people are living with dementia globally. Global policies have suggested that screening for dementia in asymptomatic populations may support risk‐reduction approaches to stem the rising numbers of people with the condition. A previous systematic review of literature up to 2012 indicated that healthcare professionals negatively view dementia screening; however, the research and clinical landscape has made significant advances in the last decade. Therefore, the aim of this systematic review is to re‐examine the attitudes and preferences of healthcare professionals since 2012 regarding primary and community care‐based dementia screening.MethodsThis review was pre‐registered on PROSPERO (CRD42024531455) and followed PRISMA guidelines. Key terms relevant to the aim were input into six databases, and articles between 2012 and 2024 were considered. Titles, abstracts and full texts were independently screened by two reviewers. Articles were eligible for inclusion if peer‐reviewed, written in English, considered primary or community care‐based dementia screening and included healthcare perspectives from either quantitative or qualitative methods.ResultsFrom 18,732 identified titles, 19 articles were included in this review. Seventeen studies presented perspectives from primary care practitioners. Key findings suggest that healthcare professionals have mixed views regarding their willingness to conduct dementia screening, although limited studies suggest an interest in engaging in dementia risk reduction. Common influences on perspectives included knowledge, skills and training; resource provision; access to a dedicated screening service and referral pathways; and stigma.ConclusionsThese findings suggest that healthcare professionals' perspectives and resource are not aligned with international policies promoting dementia screening. When considering implementing evidence‐based dementia screening in the future, a dedicated screening service is recommended.
The Psychosis MRIShared Data Resource (Psy‐ShareD)
Authors: Allen Paul , Zurita Mariana , Easmin Rubaida , Bucci Sara , Kempton Matthew J. , Rogers Jack , Mehta Urvakhsh M. , McGuire Philip K. , Lawrie Stephen M. , Whalley Heather , Gadelha Ary , Murray Graham K. , Garrison Jane R. , Frangou Sophia , Upthegrove Rachel , Evans Simon L. , Kumari Veena ,   the Psy‐ShareD Partnership
Published: February 2025

ABSTRACTNeuroimaging research in the field of schizophrenia and other psychotic disorders has sought to investigate neuroanatomical markers, relative to healthy control groups. In recent decades, a large number of structural magnetic resonance imaging (MRI) studies have been funded and undertaken, but their small sample sizes and heterogeneous methods have led to inconsistencies across findings. To tackle this, efforts have been made to combine datasets across studies and sites. While notable recent multicentre initiatives and the resulting meta‐ and mega‐analytical outputs have progressed the field, efforts have generally been restricted to MRI scans in one or two illness stages, often overlook patient heterogeneity, and study populations have rarely been globally representative of the diversity of patients who experience psychosis. Furthermore, access to these datasets is often restricted to consortia members who can contribute data, likely from research institutions located in high‐income countries. The Psychosis MRI Shared Data Resource (Psy‐ShareD) is a new open access structural MRI data sharing partnership that will host pre‐existing structural T1‐weighted MRI data collected across multiple sites worldwide, including the Global South. MRI T1 data included in Psy‐ShareD will be available in image and feature‐level formats, having been harmonised using state‐of‐the‐art approaches. All T1 data will be linked to demographic and illness‐related (diagnosis, symptoms, medication status) measures, and in a number of datasets, IQ and cognitive data, and medication history will also be available, allowing subgroup and dimensional analyses. Psy‐ShareD will be free‐to‐access for all researchers. Importantly, comprehensive data catalogues, scientific support and training resources will be available to facilitate use by early career researchers and build capacity in the field. We are actively seeking new collaborators to contribute further T1 data. Collaborators will benefit in terms of authorships, as all publications arising from Psy‐ShareD will include data contributors as authors.
Erector spinae plane block with liposomal bupivacaine for post‐cesarean analgesia
Authors: Feldman Sara , Holmes Romel J. , Fuller Matthew , Habib Ashraf S. 
Published: February 2025

AbstractPurposeThe aim of the current study was to assess the analgesic efficacy of erector spinae plane block with liposomal bupivacaine in women undergoing cesarean delivery.MethodsWe prospectively enrolled patients undergoing elective cesarean delivery under spinal or combined spinal epidural anesthesia. At the end of surgery, a bilateral ESPB was performed. All patients received a standardized intraoperative and postoperative multimodal analgesic regimen. Prospectively enrolled patients were matched with historical controls who received the same multimodal analgesic regimen but no truncal blocks. The primary outcome was postoperative oxycodone consumption 0–48 h. Secondary outcomes included opioid consumption through 24 h, time to first opioid rescue, area under the curve of visual analog scale pain intensity scores through 48 h, need for treatment of postoperative nausea and vomiting and pruritus, and proportion of opioid‐free patients.ResultsThirty prospectively enrolled patients were matched with 120 historical controls. There were no significant differences between the groups in 48‐h oxycodone consumption (median, 12.5 [interquartile range (IQR), 5.0–40.0] vs. 25.0 [IQR, 3.8–50.0 mg], P = 0.38). There were also no significant differences between the groups in any of the secondary outcomes, but the area under the curve for pain scores 0–48 h was significantly lower in the ESPB group compared with the historical controls (median, 115 [IQR, 26–151] vs. 140 [IQR, 86–180], P = 0.007).ConclusionESPB with liposomal bupivacaine did not reduce postoperative opioid consumption but was associated with reduced pain scores compared with historical controls not receiving a truncal block. Future studies with a larger sample size are needed to further assess whether ESPB provides clinically significant benefit in this patient population.Trial Registration: The study was registered on clinicaltrials.gov on 12/09/2022 (NCT05664958, principal investigator Ashraf S. Habib https://clinicaltrials.gov/study/NCT05664958).
Diagnosis of Hereditary Leiomyomatosis and Renal Cell Cancer After Subcapsular Renal Hematoma
Authors: Soya Kazuma , Fujimoto Takeru , Takahashi Daisuke , Kohashiguchi Kana , Takei Yusuke , Sugino Yoshio , Iwamura Hiroshi 
Published: February 2025

ABSTRACTIntroductionHereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal dominant genetic disorder. We report a case diagnosed with HLRCC following a subcapsular renal hematoma caused by a tumor.Case PresentationA 28‐year‐old woman with a history of uterine myomas presented with left back pain. Computed tomography revealed a renal mass with a subcapsular hematoma, and coil embolization was performed. The tumor had enlarged rapidly, and 18F‐fluorodeoxyglucose positron emission tomography/computed tomography revealed significant 18F‐fluorodeoxyglucose uptake, suggesting malignancy. Subsequently, robot‐assisted radical nephrectomy was performed. Histopathological examination confirmed papillary renal carcinoma (Stage pT2aN0M0). Fumarate hydratase immunostaining was negative, and a fumarate hydratase gene pathogenic germline variant confirmed the HLRCC diagnosis. No recurrence has been reported for 2 years since the surgery.ConclusionA combination of imaging tests using multiple modalities and close follow‐ups contributed to establishing an accurate diagnosis and providing early definitive treatment.