bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Lipoherb with Metformin on Metabolic Parameters and Sex Hormones in Rats with Polycystic Ovary Syndrome
Authors: Tavakoli Fatemeh , Emami Azadeh , Heydari Behrooz , Abbasi Mohsen , Rezvani Mohammad Ebrahim 
Published: February 2023

Introduction: The purpose of the present study was comparing the effects of Lipoherb with metformin on metabolic changes and sex hormones of rats with polycystic ovary syndrome
Methods: Thirty female Wistar rats were divided into 5 groups (n=6). Group (1): received normal saline for 56 days, group (2): received letrozole (1mg/kg) for 28 days and normal saline for the next 28 days, group (3): in the first 28 days, they received letrozole carrier and in the next 28 days, they received Lipoherb (320 mg/kg), group (4): they received letrozole (1mg/kg) for 28 days and Lipoherb (320 mg/kg) in the next 28 days, group (5): they received letrozole (mg/kg) for 28 days and metformin (250 mg/kg) in the next 28 days. Letrozole at the dose of 1 mg/kg for 28 days induced polycystic ovary syndrome. At the beginning and at the end of the experiment, fasting blood sugar level, lipid profile and sex hormones were measured by ELISA method.
Results: Blood sugar in the letrozole plus metformin group was significantly lower than letrozole group (P<0.01). The amount of serum triglyceride and LDL cholesterol in the group that received letrozole and Lipoherb were significantly decreased compared to letrozole group (P>0.05). In the same group, total cholesterol concentration also decreased significantly compared to other groups (P>0.01). The serum level of estrogen in the group received Lipoherb was significantly lower compared to letrozole group (P<0.05).
Conclusion: Compared to metformin, Lipoherb had more ability to correct the metabolic symptoms of rats with polycystic ovary syndrome. However, the hormonal effects of Lipoherb did not differ significantly from the hormonal effects of metformin in polycystic ovary syndrome.
Construção de um novo perfil de radiação solar e temperatura do ar a partir de padrões climáticos conhecidos para a cidade de Belém-PA
Authors: Borges Larissa dos Santos , Nobre Jean Carlos de Almeida , Sousa David Lohan Pereira de , Andrade Luiz Claudio Fialho 
Published: February 2023

Nesta pesquisa manipulam-se cinco bases de dados diferentes, para obtenção de um novo perfil climático a partir de uma análise estatística da média, mínima, máxima e desvio padrão das variáveis de radiação solar e temperatura do ar para a cidade de Belém-PA. Existe um período de catalogação para cada arquivo climático, no TMY (2007-2021) são quatorze anos de coleta de dados, SWERA (1973-1997) vinte e quatro anos, IWEC (1982-1995) treze anos, TRY (1964) um ano e INMET (2010) um ano. A variabilidade da coleta amostral, permitiu realizar uma simulação mais precisa dos valores médios das variáveis estudadas. A disposição dos dados climatológicos no acervo dos arquivos utilizados necessita de um tratamento estatístico a fim de viabilizar o seu uso em pesquisas e simulações na área de desempenho térmico e eficiência energética. Nessa área, uma das dificuldades enfrentadas pelos pesquisadores é a escolha do arquivo climático, dessarte, foi feita a análise de fontes distintas de coleta e extraído um novo conjunto de dados. Foi simulado com auxílio do software OpenStudio, o comportamento das temperaturas de bulbo seco e bulbo úmido e das taxas de radiação solar direta e difusa para cada arquivo climático, no intuito utilizar medidas de centralidade e dispersão como parâmetros na obtenção e validação estatística do novo perfil.
„Woleli opowieść o życiu”. O dwóch picture-bookach Iwony Chmielewskiej
Authors: Jarniewicz Jerzy 
Published: February 2023

Artykuł, poświęcony rosnącej popularności picture-booków i kłopotom z ich definicją, koncentruje się na twórczości Iwony Chmielewskiej, autorki związanej z tematyką Zagłady. Szczegółowo omówione zostają jej dwie książki, Pamiętnik Blumki (2011) i Dopóki niebo nie płacze (2016), reprezentujące różne odmiany tego gatunku, będące eksperymentami w poszukiwaniu nowych form książki jako materialnego i wizualnego obiektu, narzucającego nielinearny porządek odbioru i problematyzującego relacje między słowem a obrazem. Podjęte zostają również kwestie etyczne w literaturze o Holokauście, wyrażające się często w wyborze między realistycznym obrazowaniem, metaforycznym skrótem a milczeniem.
Cały świat jest alegorią. Recenzja książki Magdaleny Kuran „Przez zarzuconą subtelną bawełnicę…” – cognitio symbolica w kazaniach reformata Antoniego Węgrzynowicza (źródła, zastosowania, konteksty), Wydawnictwo Uniwersytetu Łódzkiego, Łódź 2022
Authors: Walińska Marzena 
Published: February 2023

Recenzja dotyczy książki Magdaleny Kuran „Przez zarzuconą subtelną bawełnicę…” – cognitio symbolica w kazaniach reformata Antoniego Węgrzynowicza (źródła, zastosowania, konteksty) (Łódź 2022). Tekst zawiera omówienie najważniejszych zagadnień poruszonych w monografii: wyjaśnienie znaczenia i roli teologii symbolicznej (oraz będącej jej częścią zasady cognitio symbolica) w twórczości Antoniego Węgrzynowicza – osiemnastowiecznego kaznodziei, członka zakonu krakowskich reformatów, autora kilkuset kazań w językach polskim i łacińskim. Podkreśla się umiejętność Autorki w rozpoznawaniu i opisie zastosowanych zabiegów alegoryzacyjnych na różnych poziomach tekstu (koncept całego zbioru, budowa poszczególnych kazań, wybrane przykłady argumentacji). Recenzowana publikacja zostaje oceniona jako niezwykle wartościowa, zarówno ze względu na bogaty materiał źródłowy, erudycję i umiejętności analityczne Autorki, jak i całościowe ujęcie twórczości krakowskiego kaznodziei.
Pengembangan Program Latihan Freeletics Terhadap Indeks Massa Tubuh (Imt) Dan Vo2max di Komunitas Freeletics Kota Surabaya
Authors: Renato Adrian , Cholid Abd , Suharti  
Published: February 2023

Kegiatan belajar dan pekerjaan yang memiliki tuntutan tugas yang harus diselesaikan dengan batas waktu yang relatif singkat. Berdampak pada berkurangnya intensitas waktu beristirahat yang dapat menimbulkan berbagai macam penyakit, meningkatnya stres seseorang yang dapat memicu kelebihan berat badan. 13,5% orang dewasa usia 18 Tahun keatas mengalami kelebihan berat badan, 28,7% mengalami Obesitas (IMT ≥ 25). Kapasitas VO2Max juga berpengaruh terhadap kinerja yang baik seseorang dalam menunjang setiap produktifitasnya dan seseorang memiliki kapasitas VO2Max yang berbeda-beda. Freeletics adalah olahraga yang menggunakan berat badan sebagai hambatannya. Melatih kekuatan otot dan daya tahan tubuh. Sifat gerakan yang intens membuat tubuh mampu membakar banyak kalori dalam tubuh. Komunitas olahraga Freeletics Kota Surabaya merupakan salah satu komunitas olahraga yang dapat memicu seseorang lebih tertarik untuk melakukan aktifitas olahraga, dapat menambah pertemanan, berpotensi meningkatkan hubungan kerjasama dalam suatu pekerjaan, dan dapat menghindari efek bosan dalam melakukan olahraga sendirian. Peneliti merumuskan penelitian pengembangan program latihan Freeletics terhadap indeks massa tubuh (IMT) dan VO2Max di komunitas Freeletics kota Surabaya. Metode penelitian menggunakan Metode Kuantitatif, dengan rancangan dukungan eksperimen Pre-Experiment dengan One Group Pretest-Posttest difungsikan pada suatu kumpulan tertentu. Berdasarkan klasifikasi sesuai Sampling Purposive yang memenuhi berjumlah 8 orang tergabung dalam 12 Weeks Program Batch 8. Beberapa uji analisis yang digunakan untuk mengolah data seperti uji normalitas, uji homogenitas, dan uji t. hasil dari pengolahan data uji normalitas, uji homogenitas, dan uji t sebagai berikut: (a) Uji Normalitas Pengolahan data: (1) Pretest dan Postest Indeks Massa Tubuh (IMT) dengan skor Signifikasi 0.181 > 0,05 dan 0.402 > 0,05, sehingga berdasarkan uji normalitas data IMT mengasilkan distribusi normal. (2) Pretest dan Postest VO2Max dengan skor Signifikasi Pretest dan Postest VO2Max pada uji Kolmogorov-Smirnov 0.332>0,05 dan 0.263>0,05, sehingga berdasarkan uji normalitas data VO2Max mengasilkan distribusi normal; (b) Uji Homogenitas di dapat skor Signifikasi IMT dan VO2Max pada uji homogenitas sebesar 0.003<0,05, hasil data data bervariasi atau bersifat Heterogen; (c) Uji t diperoleh skor Sig. (2-tailed) sebesar (0.004 < dari 0.05), menunjukan nilai Sig. (2-tailed) lebih kecil nilai probabilitas 0,05 dan dapat disimpulkan ada pengaruh program latihan Freeletics terhadap indeks massa tubuh (IMT) dan VO2 Max.
Molecular detection by some virulence genes of Salmonella enterica subsp. enterica isolated from the stool of children with diarrhea
Authors: Maaroof Mohammed Nadhir , Dhayea Ahmed Hussein 
Published: February 2023

Diarrhea is a real disease in childhood which could cause death. Therefore, this study was conducted to isolate Salmonella from 350 stool samples taken from children under five years in age, suffering from diarrhea during the period from March 2019 to March 2020 in Tikrit city / Iraq. The results showed the possibility to isolate ten isolates of Salmonella enterica subsp. Enterica, an infection rate, represents 2.875% of the total rate of patients who suffer from diarrhea. The virulence genes were investigated for ten isolates of S. enterica subsp. enterica, the result is that all isolates possessed the genes stn, invA, lpfA with an appearance percentage of 100%, while the percentage of appearance of pefA and fimH genes was 80% and 60%, respectively. All these isolates as Iraqi detection have been submitted to NCBI then accepted as ten Iraqi strains were in NCBI. All strains were concordance of 99-100% with the Salmonella enterica subsp. enterica Strains of Taiwan (CP085821.1), the United Kingdom (OU943338.1), China (CP085699.1), South Korea (CP077760.1), Pakistan (OK035700.1) and Hong Kong (CP0823381.1) in addition to four US states.
Watermark Based on Singular Value Decomposition
Authors: Qazzaz Ali Abdulazeez Mohammed Baqer , Kadhim Neamah Enad 
Published: February 2023

Watermarking operation can be defined as a process of embedding special wanted and reversible information in important secure files to protect the ownership or information of the wanted cover file based on the proposed singular value decomposition (SVD) watermark. The proposed method for digital watermark has very huge domain for constructing final number and this mean protecting watermark from conflict. The cover file is the important image need to be protected. A hidden watermark is a unique number extracted from the cover file by performing proposed related and successive operations, starting by dividing the original image into four various parts with unequal size. Each part of these four treated as a separate matrix and applying SVD on it, the diagonal matrix is selected to determine its norm. The four norms will be processed to produce one unique number used as a watermark and this number can be developed in future by exploiting some other features in constructing watermark number other than SVD process to construct two watermark numbers, each one of them owned special methodology, for avoiding some challenges and changings in the transformation process.
Effects of Water Stress, Nitrogen, Magnesium and their Interactions on Some Growth Characteristics and Essential Oil content of Rosemary (Rosmarinus officinalis L.)
Authors: Khaleel Nahla M. A. , Sarmamy Abdulghany O. I. 
Published: February 2023

A factorial experiment was applied with four replicates on rosemary plants (Rosmarinus officinalis L.) grown in pots inside the glasshouse of the Department of Biology, College of Science, Salahaddin University, Erbil, Iraq, during April, 2019 to July, 2020, to determine the effects of soil moisture content ( SM1: 100% and SM2: 60% field capacity), nitrogen fertilizer (N1: 100, N2: 200 and N3: 300kg/hectare), and magnesium fertilizer (Mg1: 0.0, Mg2: 30 and Mg3: 60kg/hectare) and their interactions on some growth characteristics and essential oil content of rosemary plants. Two cuttings were taken from rosemary shoots (on March, 2020 and July, 2020) after 12 and 15 months of planting respectively. Results showed that cutting 1: SM2 decreased plant height, number of branches, Shoot fresh weight (FW), shoot dry weight (DW), leaves DW & stem DW. N3 increased plant height, number of branches, Shoot FW, shoot DW, leaves DW, stems FW & stem DW. Interaction treatment SM1N3Mg3 increased plant height, Shoot FW, shoot DW, leaves DW, stems FW and stem DW, while in cutting 2: SM2 decreased shoot DW, stems FW and stem DW. N3 increased Shoot FW and stem DW. Mg3 increased Root FW, but decreased stems FW. SM1N3Mg1 increased stem DW. In cutting 1+ cutting 2, SM2 decreased accumulative stem DW and biological yield FW. N3 increased accumulative Shoot FW; Accumulative leaves DW, accumulative stem FW, accumulative yield FW and biological yield DW. Mg3 increased biological yield FW, while SM1N3Mg3 treatment increased accumulative shoot DW, accumulative leaves DW, biological yield FW, and biological yield DW. In the second harvest, SM2 and Mg2 decreased rosemary essential oil %, N3 and SM1N3Mg2increased EO% and concrete content, while SM1Mg2 increased EO.
STRAS:a snakemake pipeline for genome wild Short Tandem Repeats Annotation and Score
Authors: Zhang Mengna 
Published: February 2023

Abstract
High-throughput whole genome sequencing (WGS) is clinically used in finding single nucleotide variants and small indels. Several bioinformatics tools are developed to call short tandem repeats (STRs) copy numbers from WGS data, such as ExpansionHunter denovo, GangSTR and HipSTR. However, expansion disorders are rare and it is hard to find candidate expansions in single patient sequencing data with ~ 800,000 STRs calls. In this paper I describe a snakemake pipeline for genome wild STRs Annotation and Score (STRAS) using a Random Forest (RF) model to predict pathogenicity. The predictor was validated by benchmark data from Clinvar. True positive rate was 100%. True negative rate was 98.3%. False positive rate was 0% and false negative rate was 1.7%. Sensitivity was 100% and specificity was 93.6%. The results showed STRAS could be a useful tool for clinical researchers to find STR loci of interest and filter out neutral STRs. STRAS is freely available at https://github.com/fancheyu5/STRAS
Detect Acute Porphyrias in Emergency Departments (DePorED) – A pilot study
Authors: Diehl-Wiesenecker Eva , Blaschke Sabine , Wohmann Nils , Kubisch Ilja , Stauch Thomas , Mainert Mona , Helm Franziska , von Wegerer Sabine , Pittrow David , Frank Jorge , Stölzel Ulrich , Somasundaram Rajan 
Published: February 2023

Abstract

Background Acute porphyrias (APs) are a group of rare metabolic diseases related to a disturbed heme biosynthesis. Symptoms may first occur as life threatening attacks, comprising abdominal pain and/or variable neuro-psychiatric symptoms, thus leading to presentation in emergency departments (ED) first. Due to the low prevalence, diagnosis of AP is often missed, even after readmission to the ED. Therefore, strategies are needed to consider APs in ED patients with unexplained abdominal pain, especially since early and adequate treatment will avoid an unfavorable clinical course. Aim of this prospective study was to investigate the prevalence of APs in ED patients and thus, addressing feasibility of screening for rare diseases, such as APs in the real life setting. Methods From September 2019 to March 2021, patients presenting to the ED of three German tertiary care hospitals with moderate to severe prolonged abdominal pain (Visual Analog Scale, VAS > 4 out of 10 points) not otherwise explained were screened and prospectively enrolled. In addition to standard of care (SOC) diagnostics a blood and urine sample for plasma fluorescence scan and biochemical porphyrin analysis were sent to a certified German porphyria laboratory. Results Overall, of 653 screened patients, 68 patients (36 females; mean age 36 years) were included for biochemical porphyrin analysis. No patient with AP was detected. The most frequent discharge diagnoses included “abdominal and digestive symptoms” (n = 22, 32%), “gastroesophageal diseases” (n = 18, 27%), “infectious bowel disease” (n = 6, 9%) and “biliopancreatic diseases” (n = 6, 9%). Although not primarily addressed, we observed an increase in knowledge of the ED staffs at all study sites regarding our screening algorithm and thus, awareness for APs. Conclusions To the best of our knowledge, we performed the first prospective screening project for APs in the ED. Although we detected no patient with AP in this study, we demonstrated the feasibility of a multicenter screening process for APs by building up a well-working infrastructure comprising laboratory testing as well as data management. This enables the set-up of a larger scale revised follow-up study with a central focus on structured education, thus, possibly acting as blueprint for other rare diseases.
Metabolomic profiling of Wilson disease, an inherited disorder of copper metabolism, and diseases with similar symptoms but normal copper metabolism
Authors: Qiu Yijie , Su Mingchuan , Xiao Xina , Zhou Dingzi , Xie Linshen 
Published: February 2023

Abstract
Wilson’s disease (WD) is an inherited disorder that leads to copper accumulation, but the detailed pathogenic mechanism is uncertain and diagnosis can be difficult without genetic testing because of similarities to other more common diseases.To investigate the metabolomic features of WD, and elucidate its difference with other normal copper metabolism disease.We performed targeted and untargeted metabolomic profiling using ultra-high performance liquid chromatography-tandemmassspectrometry (UPLC-MS/MS) and liquid chromatography-tandemmassspectrometry (LC-MS).We compared the metabolomic profiles of two subgroups of WD patients, hepatic WD(H-WD)and neurological WD (N-WD); of H-WD patients and liver cirrhosis patients (who have similar symptoms, but normal copper levels);and of N-WD patients and Parkinson’s disease patients (who have similar symptoms, but normal copper levels). Pairwise comparisons indicated distinctive metabolomic profiles for male and female WD patients, H-WD and N-WD patients, N-WD and Parkinson’s disease patients, and H-WD and liver cirrhosis patients. We then used logistic regression analysis, receiver operating characteristic (ROC) analysis, and model construction to identify candidate diagnostic biomarkers that distinguish H-WD from liver cirrhosis, and N-WD from Parkinson’s disease. Based on the spatial distribution of the data obtained by PLS-DA analysis, we found that there are different hydrophilic metabolites (aminoacyl-tRNA biosynthesis; alanine, aspartate, and glutamate metabolism; phenylalanine metabolism; arginine biosynthesis; and nicotinate and nicotinamide) and lipophilic metabolites (TG(16:0_16:1_22:6), TG(16:0_16:0_22:6) and TG(16:0_16:1_22:5)) between H-WD and N-WD. Furthermore, WD patients have metabolic characteristics that distinguish it from other analogous diseases (liver cirrhosis and Parkinson's disease). Through analysis, WD showed significant differences in the levels of metabolites in some critical metabolism pathways and in the levels of many lipids. ROC analysis indicated that 3 metabolites may be considered as candidate biomarkers for diagnosing WD.
Interactive mechanical product innovation design method based on FBS extended by behavior layer
Authors: BAI Zhonghang , SUN Yiwei , ZHANG Jinzhu , LI Chenhui , HAO Yufan , TAN Runhua 
Published: February 2023

Abstract
Function-behavior-structure (FBS) method models the functional structure and principle scheme in conceptual design by connecting three variables: product function, behavior, and structure. The traditional FBS method cannot deal effectively with the cooperation problem between man and machine in the function achievement process. This paper proposes an FBS-based interactive mechanical product design method by extending the behavior layer. First, define and transform operational behavior from the function to the behavior layer. Second, the genetic engineering method is used in expected operational behavior design. In this part, the operational behavior as genetic information is constructed to operational behavior genes model by Extenics theory. Based on a homology product sample library, screen the target gene through the GloVe model and similarity algorithm. The original operational behavior is then modified to an expected one by Extenics transformation. Finally, the product structure is obtained through an analogy transformation process. This way, the operational behavior problem in the interactive mechanical product can be solved by this FBS design process. The feasibility and effectiveness of the proposed process are verified in the development of an apple picking device.
Extracting functionally accurate context-specific models of Atlantic salmon metabolism
Authors: Vik Jon Olav , Molversmyr Håvard , Øyås Ove , Rotnes Filip 
Published: February 2023

Abstract
Constraint-based models (CBMs) are used to study metabolic network structure and function in organisms ranging from microbes to multicellular eukaryotes. Published CBMs are usually generic rather than context-specific, meaning that they do not capture differences in reaction activities, which, in turn, determine metabolic capabilities, between cell types, tissues, environments, or other conditions. Only a subset of a CBM's metabolic reactions and capabilities are likely to be active in any given context, and several methods have therefore been developed to extract context-specific models from generic CBMs through integration of omics data. We tested the ability of six model extraction methods (MEMs) to create functionally accurate context-specific models of Atlantic salmon using a generic CBM (SALARECON) and liver transcriptomics data from contexts differing in water salinity (life stage) and dietary lipids. Three MEMs (iMAT, INIT, and GIMME) outperformed the others in terms of functional accuracy, which we defined as the extracted models' ability to perform context-specific metabolic tasks inferred directly from the data, and one MEM (GIMME) was faster than the others. Context-specific versions of SALARECON consistently outperformed the generic version, showing that context-specific modeling better captures salmon metabolism.
Hematological Characteristics of Autochthonous Hypermicrofilaremic Dirofilariosis in Dogs in Kannur District of Kerala
Authors: Edana Georgen G. , P PREENA , Balan C. , Sarangom Sherin B. , Vijayakumar K. 
Published: February 2023

Abstract
This study aimed to determine whether autochthonous high-intensity D. repens microfilaremia leads to haematological changes in companion dogs. Dogs with hypermicrofilaremia presented to the District Veterinary Centre, Kannur were selected for the study. A total of one hundred animals were positive for hypermicrofilariaemia with D. repens based on peripheral blood smear examination and Knott’s test. Of these, three dogs were concurrently positive for sheathed microfilaria (MF) of Brugia spp. Interestingly, an adult live worm of D. repens approximately eight cm in length was detected on a subcutaneous mass on the hind limb of a hypermicrofilaremic animal in the study. We compared the hematological parameters of 100 autochthonous hypermicrofilaremic dogs and 15 uninfected dogs. The hematological findings in the study are nonregenerative mild to moderate anemia, moderate to severe thrombocytopenia, leucocytosis with granulocytosis, lymphocytosis and monocytosis in comparison to the uninfected group of dogs. The pathogenicity of naturally occurring hypermicrofilaremia is poorly studied, and knowledge of its epidemiology, host-parasite relationship and impact on various organs is warranted for better prevention and control, especially in hot-spot areas.