bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of MCI conversion using sulcal morphometry
Authors: Sighinolfi Giovanni , Mitolo Micaela , Pizzagalli Fabrizio , Lodi Raffaele , Stanzani-Maserati Michelangelo , Remondini Daniel , Capellari Sabina , Liguori Rocco , Tonon Caterina , Testa Claudia 
Published: August 2023

We investigated the capabilities of brain sulcal morphometry and cortical thickness (CT) to predict the conversion from MCI stage to AD and explored the correlation with neuropsychological performance. Sulcal surface, mean depth, length and width were analysed. The width showed the best capability to discriminate between HC, MCI and AD (also in comparison to CT), and was able to distinguish at baseline converter MCI from non-converter MCI. Moreover, the width of specific frontal sulci correlated with memory and language performance. Sulcal morphometry emerged as a useful tool, capable of providing potential biomarkers for MCI conversion.
BOLD PSF: Impact of k-space sampling on T2* contrast
Authors: Engel Maria , Kasper Lars , Pruessmann Klaas 
Published: August 2023

The timing of BOLD-fMRI is typically chosen such that TE matches T2*. This assumes contrast being exclusively elicited by signal differences at TE. While sensible for short or TE-symmetric readouts, such as EPIs, it oversimplifies contrast generation for longer or TE-asymmetric trajectories, such as spirals. We propose the concept of a BOLD PSF for a more comprehensive perspective on the imaging characteristics of a functional experiment. Our findings indicate that TE can be reduced for spiral-out without sacrificing BOLD-sensitivity when compared to EPI. Furthermore, we characterize the intrinsic trade-off between specificity and resolution of the BOLD response under varying TE.
RNA Sequencing for Solid Tumor Fusion Gene Detection: Proficiency Testing Practice and Performance Comparison
Authors: Bridge Julia A. , Halling Kevin C. , Moncur Joel T. , Souers Rhona J. , Hameed Meera R. , Fernandes Helen , Roy Angshumoy , Surrey Lea , Tafe Laura J. , Vasalos Patricia , Lopez-Terrada Dolores H. 
Published: August 2023

Context
Next-generation sequencing–based approaches using RNA have increasingly been used by clinical laboratories for the detection of fusion genes, intragenic rearrangements, and exon-skipping events. Correspondingly, the College of American Pathologists (CAP) has advanced RNA sequencing proficiency testing (PT) to ensure optimal performance of these assays.

Objective
To report on laboratory performance and practices of RNA sequencing for the detection of fusion genes, intragenic rearrangements, and exon-skipping events using CAP PT data from 8 mailings (2018-A through 2021-B).

Design
CAP PT RNA sequencing program results from 153 laboratories across 24 proficiency test specimens, interrogating 22 distinct engineered fusion transcripts, were analyzed for correct identification of the fusion event, associated performance variables, and laboratory practices.

Results
Overall, the 4-year program detection rate (sensitivity) was 95.5% (1486 of 1556 results). False-negative rates were 3.6% (53 of 1463) and 18.3% (17 of 93) for fusion gene and intragenic rearrangement/exon-skipping events, respectively. Only 19 false-positive results were reported among the 8 PT mailings, and most were likely the result of preanalytical or postanalytical errors. There were no practice characteristics (eg, instrumentation, sequencing method) significantly associated with the fusion detection results.

Conclusions
These data reveal a high overall sensitivity and specificity for fusion gene detection by participating laboratories using clinical RNA sequencing. Performance was comparable across all laboratories, regardless of methodology. The fraction of false-negative results for intragenic rearrangement/exon-skipping events was greater than that for the chimeric fusion genes. False-negative results could not be attributed to any specific practice characteristics.
Selecting Green Supplier for Perishable Raw Materials using AHP Method at Nunia Boutique Villa Seminyak
Authors: Paramita Komang Devi , Nadra Nyoman Mastiani , Winia I Nyoman , Mudana I Gede , Anggraheni Raden Roro Rieta 
Published: August 2023

Purpose: The aim of this research is to do the selection for green supplier for perishable raw material at Nunia Boutique Villa, Villa with 8 Units Villa located at Seminyak Badung Bali.
Research methods: One of the methods that used in this research is Analytical Hierarchy Process (AHP) method with Vendor Performance Index (VPI) is a Quality, Cost, Delivery, Flexibility, and Responsiveness (QCDFR) by adding the Environment Management criteria. This research used the AHP method with the expert choice software.
Findings: The final rating of relative importance’s supplier selection criteria was found: the Quality criteria (0.472) was ranked first in the order of priority in the green supplier selection criteria.
Implication: The Cost criteria with 0.192, Environment Management criteria (0.102), Delivery criteria (0.091), Flexibility criteria (0.076) and the last criterion is Responsiveness (0.067).
Analysis of Green Practices Implementation at FourStar by Trans Hotel Restaurant
Authors: Putra Gede Ari Ambara , Bagiastuti Ni Ketut , Astuti Ni Nyoman Sri , Suparta I Ketut , Suja I Ketut 
Published: August 2023

Purpose: This study aims to determine the implementation of green practices that have been implemented and which need to be improved at the FourStar by Trans Hotel restaurant. Green Practice is an action to protect the environment and the resulting product is less damaging to the environment. Restaurants that imple-ment green practice usually focus on reduce, reuse, and recycle as well as energy and efficiency.
Research methods: The research data were sourced from participatory interview and observation methods at the research location which were then processed us-ing triangulation techniques.
Findings: The results of the study show that the implementation of green practic-es has been implemented properly and adequately in restaurants although there are several indicators of green practice that still need to be improved.
Implication: Indicators that need to be maintained include the use of recyclable containers, the use of energy-efficient lighting and the use of a temperature com-fort control system, as well as the installation of signs and policies that need to be implemented, and indicators that need to be improved are educating the pub-lics about green practices in a sustainable manner, Implementing funding for ac-tivities that support environmentally friendly direction and donating organic wastes as the use of animal feed for the community.
Analysis of technical characteristics of typical lower limb balance movements in Tai Chi: a cross-sectional study based on AnyBody bone muscle modeling
Authors: Li Haojie , Wang Xin , Du Zhihao , Shen Shunze 
Published: August 2023

Background
Tai Chi is an excellent traditional Chinese physical fitness exercise, and its unique balancing movements are very important for improving human balance. In this study, the two most representative Tai Chi balance movements, “knee lift balance” and “leg stirrup balance”, were selected to establish the lower limb bone muscle model of Tai Chi balance movements by using computer simulation modeling technology, aiming to analyze the characteristics of the lower limb movement mechanisms of typical balance movements, to provide a quantitative theoretical basis for improving the scientific level of Tai Chi.

Method
A total of 16 subjects were recruited for this study. the BTS three-dimensional motion capture system and three-dimensional force platform were used for motion data acquisition, the physiological electromyographic signals were collected using BTS surface electromyography, and the lower limb bone muscle model of Tai Chi balance movements was established by AnyBody human simulation.

Result
In the knee lift balancing movement, the balance leg hip abduction/adduction angle, hip flexion/extension moment, and the strength of the rectus femoris muscle, biceps femoris short capitis, and iliacus muscle of the amateur group was significantly smaller than that of the professional group (P < 0.01). In the leg stirrup balance movement, the knee flexion/extension angle of the balancing leg in the amateur group was significantly greater than that in the professional group (P < 0.01), and the hip flexion/extension angle, hip inversion/abduction angle, knee flexion/extension moment, hip flexion/extension moment, the strength iliacus, gluteus maximus, and obturator internus were significantly smaller than those in the professional group (P < 0.01). The integral EMG of the biceps femoris of the support leg in the amateur group was significantly smaller than that of the professional group (P < 0.01). The integral EMG of the lateral femoral muscle of the balance leg was significantly smaller than that of the professional group (P < 0.01).

Conclusion
In this study, we found that the balancing leg of the balancing movement has a larger hip joint angle, the stirrup balancing knee joint angle is smaller, and the hip and knee joint moments are larger. This is related to joint activity and muscle activation, and amateurs should pay attention to increasing the range of motion of the hip joint and decreasing the range of motion of the knee joint when practicing to better stimulate exercise of the lower limb joints. In addition, the practice of balancing movements should strengthen the iliacus muscle, which plays an important role in maintaining the stable balance of the lower limbs, and strengthen the knee flexor and extensor muscles and hip adductor/abductor muscles of the balancing leg, thus promoting the stability of the balancing leg movements.
Kamar Ganti Virtual: Retail Berkelanjutan di Era Big Data
Authors: Renaningtyas Luri , Hody Dibya Adipranata 
Published: August 2023

Sejak pandemi penggunaan teknologi dalam setiap aspek kehidupan meningkat. Dengan bantuan teknologi semua dapat diperoleh dengan cepat dan instan. Belanja dilakukan secara remote, termasuk belanja fashion. Retail bergeser dari bangunan fisik di mal menjadi antarmuka di genggaman handphone konsumen. Konsumen tidak perlu datang dan mencoba pakaian yang dibeli. Di Tokopedia atau Shopee, platform belanja online terbesar di Indonesia, segera setelah konsumen memilih pakaian mana yang disuka berdasarkan foto produk yang ditampilkan, konsumen dapat langsung membelinya. Lebih jauh lagi ada aplikasi Virtual Try-On (VTO) seperti Browzwear dan Lalaland yang memungkinkan konsumen mencoba langsung baju yang akan dibeli. Penelitian ini memberikan gambaran kepada pelaku bisnis fashion, akademisi, dan peneliti tentang bagaimana fashion retail mengkomunikasikan produknya kepada konsumennya dengan memanfaatkan Augmented Reality (AR)/Machine Learning (ML)/Computer Vision (CV) di era big data menggunakan dataset yang terdiri dari ribuan atau jutaan foto. Hal ini membuat proses produksi dan konsumsinya lebih cepat dan lebih hemat, sehingga implementasi AI juga dapat dipandang sebagai salah satu alternatif yang berkelanjutan. Metode penelitian terdiri dari dua tahap. Pertama yaitu dengan analisis jurnal-jurnal sains komputer serta investigasi aplikasi-aplikasi AR seperti Zero 10 dan software 3D seperti CLO atau Browzwear, dikaitkan dengan isu berkelanjutan dengan tujuan untuk mengidentifikasi cara kerja Virtual Try-On. Tahap selanjutnya dilakukan analisis terhadap cara kerja VTO dari perspektif komunikasi brand terhadap konsumen, agar dapat mendeskripsikan seperti apa retail berkelanjutan di era big data.
Oral Human Papillomavirus Prevalence and Genotyping Among a Healthy Adult Population in the US
Authors: Giuliano Anna R. , Felsher Marisa , Waterboer Tim , Mirghani Haïtham , Mehanna Hisham , Roberts Craig , Chen Ya-Ting , Lynam Mark , Pedrós Montse , Sanchez Emilio , Sirak Bradley , Surati Shikha , Alemany Laia , Morais Edith , Pavón Miquel Angel 
Published: August 2023

ImportanceIn the US, oropharyngeal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection, is the most frequent HPV-associated cancer, surpassing cervical cancer. However, little is known about oral HPV prevalence and genotype distribution in the general population.ObjectiveTo assess oral HPV prevalence and factors associated with HR and low-risk infection in a general US population.Design, Setting, and ParticipantsPROGRESS (Prevalence of Oral HPV Infection, a Global Assessment) was a cross-sectional observational study conducted between November 2021 and March 2022 in 43 dental offices in the US (24 urban, 13 urban cluster, and 6 rural sites), spanning 21 states. Eligible participants were aged 18 to 60 years, visiting dental clinics for routine dental examination. Dental clinics used targeted sampling to recruit equal distributions of men and women and across age groups.ExposureParticipants provided an oral gargle specimen for HPV DNA and genotyping and completed behavioral questionnaires, and dentists reported oral health status. Detection of HPV DNA and genotyping was performed using the SPF10/DEIA/LiPA25 system at a central laboratory.Main OutcomeOral HPV prevalence.ResultsOf the 3196 participants enrolled, mean (SD) age was 39.6 (12.1) years, and 55.5% were women. Oral HPV prevalence was 6.6% (95% CI, 5.7%-7.4%) for any HPV genotype, and 2.0% (95% CI, 1.5%-2.5%), 0.7% (95% CI, 0.4%-1.0%), and 1.5% (95% CI, 1.1%-1.9%) for HR, HPV-16, and 9-valent-HPV vaccine types, respectively. Among HPV-positive participants, HPV-16 was the most prevalent genotype (12.4% among men and 8.6% among women). Prevalence of HPV was higher in men than women and highest among men aged 51 to 60 years (16.8%, 6.8%, and 2.1% for any HPV, HR HPV, and HPV-16, respectively). Factors associated with HR oral infection included being male (adjusted odds ratio [AOR], 3.1; 95% CI, 1.2-8.5), being aged 51 to 60 years (AOR, 3.3; 95% CI, 1.5-7.3), having 26 or more lifetime male sex partners (AOR, 6.5; 95% CI, 2.3-18.7), and having 6 to 25 lifetime female oral sex partners (AOR, 3.4; 95% CI, 1.3-8.7).Conclusions and RelevanceIn this cross-sectional study, oral HPV burden was highest among older men who may be at higher risk of developing oropharyngeal cancer. In addition to male sex and older age, HR oral HPV infection was also associated with sexual behaviors, including increasing number of male sex partners and female oral sex partners.
Characterization of mechanical and radiation isocenter on an MR‐guided radiotherapy (MRgRT) Linac
Authors: Bassiri Nema , Bayouth John E. , Mittauer Kathryn E. 
Published: August 2023

AbstractBackground and PurposeIn the emerging paradigm of stereotactic radiosurgery being proposed for MR‐guided radiotherapy (MRgRT), assessment of mechanical geometric accuracy is critical for the implementation of stereotactic delivery. We benchmarked the mechanical accuracy of an MR Linac system that lacks an onboard detector/array. Our mechanical tests utilize a half beam block (HBB) geometry that takes advantage of the sensitivity of a partially occluded detector.Materials and MethodsMechanical tests benchmarked the couch, MLC, and gantry geometric accuracy for an MR‐Linac system. An HBB technique was used to irradiate an ionization chamber profiler (ICP) array with partial occlusion of individual detectors for characterization of MLC skew, beam divergence displacement, and RT isocenter localization. The sensitivity of the partially occluded detector's ICP‐X (detector width) and ICP‐Y (detector length) was characterized by displacing the detector relative to radiation isocenter by 0.2 mm increments, introduced through couch motion. The accuracy of the HBB ICP technique was verified with a starshot using radiochromic film, and the reproducibility was verified on a conventional C‐arm Linac and compared to Winston‐Lutz.ResultsThe sensitivity of the HBB technique as quantified through the dose difference normalized to open field as a function of displacement from RT isocenter was 6.4%/mm and 13.0%/mm for the ICP‐X and ICP‐Y orientation, respectively, due to the oblong detector orientation. Couch positional accuracy and sag was within ±0.1 mm. Maximum MLC positional displacement was 0.7 mm with mean MLC skew at 0.07°. The maximum beam divergence displacement was 0.03 mm. The gantry angle was within 0.1°. Independent verification of the RT isocenter localization procedure produced repeatable results.ConclusionThis work serves for characterizing the mechanical and geometric radiation accuracy for the foundation of an MR‐guided stereotactic radiosurgery program, as demonstrated with high sensitivity and independent validation.
Functional 2D Phases in Mixed Dimensional Perovskite Photovoltaics
Authors: Hu Fan , Lou Yan‐Hui , Wang Zhao‐Kui 
Published: August 2023

AbstractOrganic‐inorganic hybrid perovskite solar cells (PSCs) with unique properties exhibit their powerful competitiveness in the photovoltaic field over the past few years. However, the challenges of stability for perovskite devices limit the commercialization and further development. The 2D/3D hybrid structures combine the superior efficiency of bulk perovskites and the superior stability of layered perovskites and gradually get hotspots of the photovoltaic field. In addition, there remains a lack of comprehensive understanding and systematic summary of the function of 2D perovskite attributed to the complex nature of 2D/3D structures. Here, the latest progress of 2D/3D hybrid structures and focus on the functionality of 2D phases in mixed structures and the underlying mechanism from the perspective of their different distributions in the perovskite layer is summarized. Then, the insight and vital factors for overall improvements in the stability of 2D/3D structures are thoroughly discussed. Finally, it is expected that this review will contribute to the present challenges and future research prospects in the photovoltaic industry.
Organic‐Solvent‐Free “Lego‐Like” Modular Preparation of Fab‐Nondestructive Antibody‐Drug Conjugates with Ultrahigh Drug‐to‐Antibody Ratio
Authors: Liu Zhilin , Zhang Honglei , Sun Jiali , Zheng Mengfei , Cui Linjie , Zhang Yu , Cheng Jianjun , Tang Zhaohui , Chen Xuesi 
Published: August 2023

AbstractAntibody‐drug conjugates (ADCs) have exciting possibilities in targeted tumor therapy. However, in the existing ADC preparation processes, the random attachment of the payloads to the antigen‐binding fragments (Fab) greatly increases the risk of disrupting its antigen recognition ability, while the drug‐antibody ratio (DAR) is low, leading to a cumbersome preparation process and low drug delivery efficiency. Herein, poly(glutamic acid) is used to expand the number of drug binding sites, based on the “click chemistry” of azide and DBCO, and the high affinity of Fc‐III‐4C peptide to the crystalline fragment (Fc) of the monoclonal antibodies. Various antibody‐polymer‐drug conjugates are obtained with ultrahigh DAR using this organic‐solvent‐free “Lego‐like” modular construction. Among them, aHER2‐P‐MMAE with DAR of 41.6 achieves tumor growth inhibition (TGI) of 99.7% for both medium‐sized and large SKOV‐3 ovarian tumors, and aPDL1‐P‐MMAE (DAR = 40.7) achieves TGI of 98.5% for MC38 colon tumors. In summary, a universal platform is created to prepare Fab‐nondestructive ADCs with ultrahigh DAR, which can be used to develop precision medicine for personalized anticancer therapy.
Enantioselective Catalytic Synthesis of α‐Stereogenic Chromen‐4‐one Amino Derivatives
Authors: Kovalevsky Ruslan A. , Vasechkin Konstantin V. , Kucherenko Alexander S. , Zlotin Sergei G. 
Published: August 2023

AbstractDirect enantioselective synthesis of 2‐substituted chromen‐4‐ones, bearing the amino group at α‐stereogenic center with respect to the heterocycle is developed. It is based on Mannich‐type asymmetric addition of 3‐hydroxychromen‐4‐one and its analogues to N‐protected imines in the presence of available alkaloid dihydrocuprein. α‐Stereogenic chromenone amino derivatives were formed in this reactions in 81–95% yield with up to 98% ee. The chiral adducts were transformed to diverse enantiomerically enriched chromen‐4‐one functional derivatives.
GGE biplot analysis of genotype by environment interaction and grain yield stability of oat (Avena sativa L.) in Ethiopia
Authors: Kebede Gezahagn , Worku Walelign , Jifar Habte , Feyissa Fekede 
Published: August 2023

AbstractA total of 24 oat genotypes were evaluated across 9 environments using a randomized complete block design with 3 replications. The combined analysis of variance indicated that grain yield was significantly affected by genotype, environment, and genotype by environment interaction (GEI). The environment's main effect explained 44.62% of the total variation, whereas the genotype and GEI captured 28.84% and 26.54%, respectively. The genotype plus genotype by environment (GGE) biplot of the first two principal components also explained (PC1 = 68.46%) and (PC2 = 11.84%) of the GEI sum of squares. G8 (SRCPX80Ab2267), G17 (SRCPX80Ab2310), G5 (Sorataf), G14 (Was), G19 (Bonsa), G22 (SRCPX80Ab2691), G12 (SRCPX80Ab2291), G11 (SRCPX80Ab2806), G4 (CI‐8251), and G16 (Jassari), which were located at the left side of the PC1, showed better grain yield performance. The smaller PC1 values were observed for G19, G14, G8, G11, G12, G17, and G22 showing better grain yield stability. The ideal genotype located at the center of the concentric circles was G19, whereas the desirable genotypes were G14, G8, G11, G12, G17, and G22. The polygon view of the GGE biplot showed that the first mega‐environment contains environment E3 (Ginchi) with G16, whereas the second mega‐environment contains environments E7 (Bekoji) and E8 (Kuyu) with G12 being the winning genotypes. The vertices of the fourth mega‐environments (E6—Kulumsa) were G8 and G17, whereas the remaining environments grouped in the third mega‐environment without vertex genotype. Furthermore, E2 (Ada‐Berga) was an ideal test environment, whereas E5 (D/Zeit), E1 (Holetta), and E4 (Jeldu) were identified as favorable environments. Regarding the mean grain yield and stability, G19, G14, G8, G11, G12, G17, and G22 were the best genotypes that can be considered adapted genotypes to wider environments.
Integrative multi‐omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention‐Deficit/Hyperactivity Disorder
Authors: Hubers Nikki , Hagenbeek Fiona A. , Pool René , Déjean Sébastien , Harms Amy C. , Roetman Peter J. , van Beijsterveldt Catharina E. M. , Fanos Vassilios , Ehli Erik A. , Vermeiren Robert R. J. M. , Bartels Meike , Hottenga Jouke Jan , Hankemeier Thomas , van Dongen Jenny , Boomsma Dorret I. 
Published: August 2023

AbstractThe evolving field of multi‐omics combines data and provides methods for simultaneous analysis across several omics levels. Here, we integrated genomics (transmitted and non‐transmitted polygenic scores [PGSs]), epigenomics, and metabolomics data in a multi‐omics framework to identify biomarkers for Attention‐Deficit/Hyperactivity Disorder (ADHD) and investigated the connections among the three omics levels. We first trained single‐ and next multi‐omics models to differentiate between cases and controls in 596 twins (cases = 14.8%) from the Netherlands Twin Register (NTR) demonstrating reasonable in‐sample prediction through cross‐validation. The multi‐omics model selected 30 PGSs, 143 CpGs, and 90 metabolites. We confirmed previous associations of ADHD with glucocorticoid exposure and the transmembrane protein family TMEM, show that the DNA methylation of the MAD1L1 gene associated with ADHD has a relation with parental smoking behavior, and present novel findings including associations between indirect genetic effects and CpGs of the STAP2 gene. However, out‐of‐sample prediction in NTR participants (N = 258, cases = 14.3%) and in a clinical sample (N = 145, cases = 51%) did not perform well (range misclassification was [0.40, 0.57]). The results highlighted connections between omics levels, with the strongest connections between non‐transmitted PGSs, CpGs, and amino acid levels and show that multi‐omics designs considering interrelated omics levels can help unravel the complex biology underlying ADHD.