bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abdominal Cancer Pain Admission in Emergency Department Vs Oncology Emergency Department
Authors: Zaslavsky Kristina , Morag Ofir , Jurkowicz Menucha , Pesah Galia , Levitan Michelle , Goor-Aryeh Itay 
Published: September 2023

Abstract
Purpose
to investigate the rates of hospitalization, opioid prescription, supportive care, hospice referral and 30-day all-cause mortality in metastatic cancer patients with abdominal pain complaints admitted to general emergency room (ER) versus the Oncology Emergency Medicine (OEM).
Methods
A retrospective cohort study was evaluated, consisting of metastatic patients with abdominal pain complaints admitted to the ER or OEM at Sheba Medical Center, between June, 2020 and May, 2022. The MDClone ADAMS Platform, a healthcare data analytics environment, was used for data collection.
Results
Patients visiting the OEM were 70% less likely to be hospitalized than patients visiting the ER (p < 0.01) and a greater proportion of patients admitted to the OEM received supportive care and hospice referrals (p < 0.01). In both emergency departments, patients who received biologic treatment were less likely to be hospitalized (p = 0.02), while patients who received opioids, fluids and antibiotics were more likely require hospitalization (p = 0.03), (p = 0.01), and (p = < 0.00) respectively.
Conclusion
Our study found out that an OEM with oncology-specific expertise enabled patients suffering from metastatic cancer to receive optimal care.
Differential growth and metal accumulation response of castor bean genotypes on a lead contaminated soil
Authors: Naveed Sahar , Mahmood Sajid , Ishaque Wajid 
Published: September 2023

Abstract
In Pakistan, probably thousands of hectares are contaminated with heavy metals. As castor plant is hyper-accumulator of heavy metals, its cultivation in the area of lead (Pb) contamination can show great potential in terms of remediation of soils. Present study aimed to evaluate the phytoremediation potential of different castor genotypes, NIAB Gold, NIAB Spineless, NIAB-2020, DS-30 and C-3 grown in pots filled with 5 kg soil, spiked with various concentrations of Pb (0, 100, 200, 400, and 800 mg kg− 1). Results showed that plant biomass and photosynthetic pigments reduced significantly with increasing Pb concentrations. Activities of superoxide dismutase and peroxidase were decreased significantly whereas catalase and ascorbate peroxidase were increased with increasing Pb levels in all genotypes. At 800 mg Pb kg− 1 soil, the highest catalase and ascorbate peroxidase activities of 12.23 and 64.43 mM/g FW, respectively, were recorded in DS-30 followed by NIAB-2020. The highest total soluble proteins (8.44 mg g− 1) were recorded in DS-30 followed by NIAB-2020 under Pb contamination at 800 mg kg− 1 soil. Lead uptake increased significantly with increasing levels of Pb and highest uptake in roots were recorded in NIAB-2020 (302 mg kg− 1) followed by DS-30 (299 mg kg− 1) under Pb contamination at 800 mg kg− 1. All genotypes showed metal translocation factor less than 1 under all Pb levels. In conclusion, NIAB-2020 and DS-30 possessed good potential with better Pb accumulation, osmolytes production and antioxidant activities compared to other castor bean genotypes.
Dynamical Onset of Light-Induced Unconventional Superconductivity – a Yukawa-Sachdev-Ye-Kitaev study
Authors: Grunwald Lukas , Kennes Dante , Passetti Giacomo 
Published: September 2023

Abstract
We investigate the dynamical onset of superconductivity in the exactly solvable Yukawa-Sachdev-Ye-Kitaev model.
It hosts an unconventional superconducting phase that emerges out of a non-Fermi liquid normal state, providing a toy model for superconductivity in a strongly correlated system.
Analyzing dynamical protocols motivated by theoretical mechanisms proposed for light-induced superconductivity, that is light-induced cooling and the dressing of Hamiltonian parameters, we investigate the exact relaxation resulting out of undercooling and interaction quenches.
While, in contrast to BCS theory, it is not possible for superconductivity to emerge following interaction quenches across the superconducting phase transition, we find that the dynamical relaxation of undercooled states universally leads to superconductivity. Despite the strong correlations, the emerging order parameter dynamics are well captured by a coarse grained Ginzburg-Landau theory for which we determine all parameters from microscopics.
Retrospective cohort study of the predictors of weight loss after 3 months of treatment with Liraglutide for patients with obesity/overweight at the “Centre d’Obésité et de Contrôle du Poids” (COCP)
Authors: Moujaes Ghassan , Azzam Wael , Maalouf Mario , Wakim Victor , Fares Jocelyn Eid 
Published: September 2023

Abstract
Objective:Different responses were observed in patients on Liraglutide therapy, where data showed more significant weight loss in some people compared to others. The aim of this study was to assess the percentage of weight loss and to determine possible weight loss predictors in Lebanese patients with obesity/overweight who were treated with Liraglutide.
Methods: This was a retrospective cohort study involving patients with obesity/overweight from the Middle East Institute of Health (MEIH) in Lebanon. Patient charts were reviewed between 2014 and 2018. A total of 100 patients fulfilled the criteria and were followed up for 3 months. Measures collected were weight and waist circumference at baseline, after 1 and after 3 months of therapy, age, gender, BMI, metformin use and presence of diabetes, hypertension or dyslipidemia.
Results: A significant weight loss of 5.79 kg and decrease in waist circumference of 7.53 cm was found after 3-months follow up. None of the chosen predictors (age, gender, cumulative liraglutide dose, weight loss after 1-month, diabetes, hypertension, dyslipidemia, HOMA-IR and concomitant Metformin treatment) could significantly predict the response to therapy.
Conclusion:Our results confirm the efficacy of Liraglutide in people with obesity/overweight in Lebanon. None of the chosen predictors seems to predict the long-term efficacy of the drug in order to identify patients who will benefit from treatment continuation.
Corrosion of carbon steel rebar in binary blended concrete with accelerated chloride transport
Authors: Hoque Kazi Naimul , Presuel-Moreno Francisco , Nazim Manzurul 
Published: September 2023

Abstract
Samples with two different binary blended concrete mixes were prepared, one containing cement replacement of 50% slag (referred here as SL mix) and the other containing cement replacement of 20% fly ash (termed here as FA mix). The water to cementitious ratio used to produce concrete specimens was 0.41. On the top surface of each specimen, various reservoir lengths that ranged from 2.5 cm to 17.5 cm were fitted, and these reservoirs were filled with a 10% NaCl solution. Electromigration was used to accelerate the transport of chlorides, with an applied potential of 9V at first, and subsequently reduced to 3V after about a week. For a period of about 1100 days, the corrosion related parameters such as concrete solution resistance, rebar potential, and corrosion current were monitored via the rebar potential measurements, linear polarization resistance (LPR) and electrochemical impedance spectroscopy (EIS) measurements, the latter used only to obtain the solution resistance. The corrosion current values determined through experimental observations were then converted to mass loss using Faraday’s law. The readings of corrosion current values (last 10 sets of readings) as well as the calculated mass loss values were found to be larger for the rebars embedded in specimens prepared with SL mix, followed by rebars embedded in specimens prepared with FA mix. Corrosion current and calculated mass loss values in general tended to increase with increasing solution reservoir lengths. No cracks or corrosion products that reached the surface of the concrete were observed on the specimens for the duration of the reported monitored propagation period. This study offers a framework for future studies on accelerated steel corrosion in concrete.
Response of Elymus nutans seedling physiology and endogenous hormones to drought and salt stress
Authors: Long Jianting , Liu Dandan , Qiao Wei , Wang Yanwei , Miao Yanjun , Baosai Henna 
Published: September 2023

Abstract
Elymus nutans, a pioneer plant for the restoration of high quality pasture and vegetation, is widely used to establish artificial grasslands and ecologically restore arid and salinized soils. To investigate the effects of drought stress and salt stress on the physiology and endogenous hormones of E. nutans seedlings, this experiment configured the same environmental water potential of PEG-6000 and NaCl stress to investigate the effects of drought stress and salt stress, respectively, on E. nutans seedlings under the same environmental water potential. The results showed that although the physiological indices and endogenous hormones of the E. nutans seedlings responded differently to drought stress and salt stress under the same environmental water potential, the physiological indices of E. nutans leaves and roots were comprehensively evaluated using the genus function method, and the physiological indices of the E. nutans seedlings under the same environmental water potential exhibited better salt tolerance than drought tolerance. The changes in endogenous hormones of the E. nutans seedlings under drought stress were analyzed to find that treatment with gibberellic acid (GA3), gibberellin A7 (GA7), 6-benzyladenine (6-BA), 6-(y,y-dimethylallylaminopurine) (2.IP), trans-zeatin (TZ), kinetin (KT), dihydrozeatin (DHZ), indole acetic acid (IAA), and 2,6-dichloroisonicotininc acid (INA) was more effective than those under drought stress. By analyzing the amplitude of changes in the endogenous hormones in E. nutans seedlings, the amplitude of changes in the contents of GA3, GA7, 6-BA, 2.IP, TZ, KT, DHZ, IAA, isopentenyl adenosine (IPA), indole-3-butyric acid (IBA), naphthalene acetic acid (NAA), and abscisic acid was larger in drought stress compared with salt stress, which could be because the endogenous hormones are important for the drought tolerance of E. nutans itself. The amplitude of the changes in the contents of DHZ, TZR, salicylic acid, and jasmonic acid was larger in salt stress compared with salt stress. Changes in the content of melatonin were larger in salt stress compared with drought stress, which could indicate that endogenous hormones and substances are important for the salt tolerance of E. nutans itself.
Lymphocyte subsets and inflammatory factors as predictors of immunotherapy efficacy in patients with hepatocellular carcinoma
Authors: Gao Shuyue , Cheng Jiamin , Qian Niansong 
Published: September 2023

Abstract
Objective：We aimed to investigate the correlation between lymphocyte subpopulations expressing inhibitor receptors, IL-6 levels, and the efficacy of immunotherapy in patients with hepatocellular carcinoma.
Methods：Blood samples were prospectively collected before and after immunotherapy from patients with intermediate and advanced hepatocellular carcinoma who were treated with immunotherapy at the Fifth Medical Center of the PLA General Hospital from August 2022 to May 2023. According to the efficacy of the patients, patients were divided into effective and ineffective groups, with 20 in the effective group and 24 in the ineffective group. We compared changes in lymphocyte subsets and IL-6 levels between the two groups. Optimal cut-off value was determined using ROC curves. Then, patients were categorized into high and low groups based on cut-off value, and the disease control rates were compared.
Results：Before immunotherapy, there were no significant differences in the baseline levels of lymphocyte subsets (PD1+TIM3+T/T, TIGIT+T/T, TIM3+T/T, CTLA4+T/T, LAG3+T/T, PD1+T/T) and IL-6 between the two groups (P>0.05). After immunotherapy, the levels of PD1+TIM3+T/T, TIGIT+T/T, and IL-6 in the effective group were lower than those in the ineffective group and these differences were statistically significant (P=0.001, P=0.008, P=0.000). However, the levels of other lymphocyte subsets showed no significant difference. Using the ROC curve to assess efficacy prediction, PD1+TIM3+T/T, TIGIT+T/T and IL-6 demonstrated high predictive ability (AUC=0.8, AUC=0.83, AUC=0.73). The predictive value of efficacy was further improved when all three factors were combined (AUC=0.93, P=0.000). Based on the ROC curve, we identified optimal cut-off value for three factors. Notably, patients with values below the optimal cut-off value had higher disease control rate.
Conclusion：The levels of PD1+TIM3+T/T, TIGIT+T/T, and IL-6 after immunotherapy may serve as predictors of treatment efficacy in patients with hepatocellular carcinoma.
An Arrhythmia Classification Approach via Deep Learning Using Single-lead ECG
Authors: Liu Liong-Rung , Huang Ming-Yuan , Huang Shu-Tien , Kung Lu-Chih , Lee Chao-hsiung , Yao Wen-Teng , Tsai Ming-Feng , Hsu Cheng-Hung , Chu Yu-Chang , Hung Fei-Hung , Chiu Hung-Wen 
Published: September 2023

Abstract
Arrhythmia, a frequently encountered and life-threatening cardiac disorder, can manifest as a transient or isolated event. Traditional automatic arrhythmia detection methods have predominantly relied on QRS-wave signal detection. Contemporary research has focused on the utilization of wearable devices for continuous monitoring of heart rates and rhythms through single-lead electrocardiogram (ECG), which holds the potential to promptly detect arrhythmias. However, in this investigation, we employed a convolutional neural network (CNN) to classify distinct arrhythmias without necessitating a signal detection step. The ECG data used in this study were sourced from publicly available databases. We randomly selected 5-second and 10-second segments of single-lead ECG data, accurately labeled for various arrhythmias, to train a one-dimensional CNN. In our experimental setup, the CNN model exhibited the capability to differentiate between Normal Sinus Rhythm (NSR) and various arrhythmias, including Atrial Fibrillation (AFIB), Atrial Flutter (AFL), Wolff-Parkinson-White syndrome (WPW), Ventricular Fibrillation (VF), Ventricular Tachycardia (VT), Ventricular Flutter (VFL), Mobitz II AV Block (MII), and Sinus Bradycardia (SB). Notably, both 10-second and 5-second ECG segments yielded a classification accuracy averaging 97.31%. This underscores the practicality of utilizing even brief 5-second recordings to detect arrhythmias in real-world scenarios.
Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinoma
Authors: Li Shang , Meersma Gert Jan , Kupryjanczyk Jolanta , de Jong Steven , Wisman G. Bea A. 
Published: September 2023

Abstract

Background: The poor chemo-response and high DNA methylation of ovarian clear cell carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the mutational landscape of the human kinome and additional cancer-related genes and found deleterious mutations in ARID1A, a component of the SWI/SNF chromatin-remodeling complex, in 46% of OCCC patients. The present study aims to comprehensively investigate whether ARID1Aloss and genome-wide DNA methylation are co-regulated in OCCC and identify putative therapeutic targets epigenetically regulated by ARID1A.
Methods: DNA methylation of ARID1Amt/ko and ARID1Awt OCCC tumors and cell lines were analyzed by Infinium MethylationEPIC BeadChip. The clustering of OCCC tumors in relation to clinical and mutational status of tumors were analyzed by hierarchical clustering analysis of genome-wide methylation. GEO expression profiles were used to identify differentially methylated (DM) genes and their expression level in ARID1Amt/ko vs ARID1Awt OCCCs. Combining three pre-ranked GSEAs, pathways and leading-edge genes epigenetically regulated by ARID1A were revealed. The leading-edge genes that passed the in-silico validation and showed consistent ARID1A-related methylation change in tumors and cell lines were regarded as candidate genes and finally verified by bisulfite sequencing and RT-qPCR.
Results: Hierarchical clustering analysis of genome-wide methylation showed two clusters of OCCC tumors. Tumor stage, ARID1A/PIK3CAmutations and TP53 mutations were significantly different between the two clusters. ARID1A mutations in OCCC were related to DM promoter or gene-body CpG islands of 2004 genes. Three pre-ranked GSEAs collectively revealed the significant enrichment of EZH2- and H3K27me3-related gene-sets by the ARID1A-related DM genes. Leading-edge DM genes (238) were extracted from the enriched gene-sets, of which 13 passed the expression-based in-silico validation and showed consistent ARID1A-related methylation change in tumors and cell lines. Bisulfite sequencing and RT-qPCR analysis showed promoter hypermethylation and lower expression of IRX1, TMEM101 and TRIP6 in ARID1Amt compared to ARID1Awt OCCC cells, which was reversed by 5-aza-2′-deoxycytidine treatment.
Conclusions: Our study shows that ARID1A loss is related to the differential methylation of a number of genes in OCCC. ARID1A-dependent DM genes have been identified as key genes of many cancer-related pathways that may provide new candidates for OCCC targeted treatment.
Genetic diversity and phylogenetic analyses of Asian lineage of Zika virus whole genome sequencing derived from Culex quinquefasciatus mosquitoes and urine of patients during the epidemic in Thailand
Authors: Phumee Atchara , Chitcharoen Suwalak , Sutthanont Nataya , Intayot Proawpilart , Wacharapluesadee Supaporn , Siriyasatien Padet 
Published: September 2023

Abstract
Zika virus (ZIKV) is a mosquito-borne flavivirus that is emerging and re-emerging. Since 2010, sporadic ZIKV cases have been reported annually in Thailand, with over 1,000 confirmed positive cases in 2016. High-throughput sequencing technologies, such as whole genome sequencing (WGS), have recently enabled the rapid sequencing of pathogen genomes. Therefore, this study used multiplex amplicon sequencing by the Illumina Miseq to describe the ZIKV WGS. Six ZIKV WGS were obtained from three samples of field-caught Culex quinquefasciatus mosquitoes and three urine samples collected from human in three different provinces of Thailand. Additionally, one ZIKV isolate was successfully isolated from a female Cx. quinquefasciatus. Based on WGS analysis, the timing of the 2020 outbreak correlates with the acquisition of five amino acid changes in the Asian lineage ZIKV strains from Thailand 2006, Cambodia 2010 and 2019, and Philippines 2012, including C-T106A, prM-V1A, E-V473M, NS1-A188V, and NS5-M872V. This mutation was found in all seven WGS, which was previously reported to be associated with significantly higher mortality rates. Moreover, phylogenetic analysis indicated that the seven ZIKV sequences belonged to the Asian lineage. The genomic region of the E gene showed the highest nucleotide diversity (0.7–1.3%). The data can be applied to develop molecular tools to better understand the virus's patterns and evolution. Furthermore, it could indicate potential targets for development of more effective to control and prevent the zika outbreak.
Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection
Authors: Israely Tomer , Tamir Hadas , Noy-Porat Tal , Melamed Sharon , Cherry Lilach , Barlev-Gross Moria , Alcalay Ron , Yahalom-Ronen Yfat , Achdout Hagit , Politi Boaz , Erez Noam , Weiss Shay , Rosenfeld Ronit , Epstein Eyal , Mazor Ohad , Makdasi Efi , Paran Nir 
Published: September 2023

Abstract
The eradication of smallpox was officially declared by the WHO in 1980, leading to discontinuation of the vaccination campaign against the virus. Consequently, immunity against smallpox and related orthopoxviruses like Monkeypox virus gradually declines, highlighting the need for efficient countermeasures not only for the prevention, but also for the treatment of already exposed individuals. We have recently developed human-like monoclonal antibodies (mAbs) from vaccinia virus-immunized non-human primates. Two mAbs, MV33 and EV42, targeting the two infectious forms of the virus, were selected for in vivo evaluation, based on their in vitro neutralization potency. A single dose of either MV33 or EV42 administered 3 days post-infection (dpi) provided full protection against lethal ectromelia virus challenge. Importantly, a combination of both mAbs conferred full protection even when provided 5 dpi. Whole-body bioimaging and viral load analysis revealed that combination of the two mAbs allowed for faster and more efficient clearance of the virus from target organs compared to either MV33 or EV42 separately. The combined mAbs treatment further conferred post-exposure protection against the currently circulating Monkeypox virus, highlighting their therapeutic potential against other orthopoxviruses.
A human rules-based game agent with TDGG and VGD for online air target intention recognition
Authors: Chen Li , Yang Jing 
Published: September 2023

Abstract
Air target intention recognition (ATIR) is critical in the modern air defense operations. Through the analysis of typical air defense combat scenarios, first, the paper defines the intention space and intention parameters of air units based on military experience and domain knowledge. Then, a human rules-based game agent for online intention recognition is proposed, with no training, no tagging, no big data support, which is not only for intention recognition, parameters prediction, but for formation identification of air targets. The most critical point of the agent is the introduction and application of thermal distribution grid graph (TDGG) and virtual grid dictionary (VGD), where the former is used to identify the formation information of air targets, and the latter is used to optimize the storage space and simplify the access process for the large-scale and real-time combat information. Finally, to have a performance evaluation and application analysis for the algorithm, we carried out a data instance analysis of ATIR and an air defense warfare simulation experiment based on a Wargame platform, both of them verified the effectiveness, practicality and feasibility of the proposed game agent compared with the classical k-means and the sector-based forward search method.