bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximizing network efficiency by optimizing channel allocation in wireless body area networks using machine learning techniques
Authors: Rao V. Chandra Shekhar , Shanmathi M. , Rajkumar M. , Haleem S.L.A. , Amirthalingam V. , Vanathi A. 
Published: July 2023

AbstractMachine learning (ML) based optimization algorithms have been applied in Wireless Body Area Networks (WBANs) for IoT health care to improve network performance. These algorithms can be used for various purposes, such as Channel allocation, Quality of service, Energy optimization, and Fault tolerance. Using a Q‐learning algorithm in WBANs can help improve the accuracy and efficiency of IoT healthcare systems, leading to better patient outcomes. The learning rate of the Q‐learning is enhanced by utilizing the Adagrad ALR optimizer. Q‐learning with Adagrad ALR optimizer‐based channel allocation can be used to optimize channel allocation by considering factors such as network congestion, link quality, and node power constraints by optimizing channel allocation. It will improve the performance of WBANs, leading to faster and more reliable medical data transmission. The proposed Q‐learning with Adagrad ALR optimizer algorithm dynamically adjusts channel allocation in real‐time based on changing network conditions, leading to more efficient use of available channels. In addition to improving network performance, ALR‐based channel allocation can help extend battery life and reduce energy consumption in WBANs. By optimizing the use of available channels dynamically, ALR algorithms can help reduce the amount of energy consumed by the network, leading to longer battery life and reduced costs associated with IoT healthcare systems. To validate the performance of the proposed Q‐learning with the Adagrad ALR optimizer method, the simulation results were compared with the three existing channel allocation mechanisms such as the Q‐learning method, PEH quality of service, and the Clustering algorithm in terms of throughput, delay, and energy efficiency. The energy efficiency of the proposed algorithm gets enhanced by 17% when compared with the other three algorithms.
Biomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia
Authors: Macica Carolyn M , Tommasini Steven M 
Published: July 2023

ABSTRACTDegenerative osteoarthritis (OA) is recognized as an early‐onset comorbidity of X‐linked hypophosphatemia (XLH), contributing to pain and stiffness and limiting range of motion and activities of daily living. Here, we extend prior findings describing biochemical and cellular changes of articular cartilage (AC) in the phosphate‐wasting environment of XLH to determine the impact of these changes on the biomechanical properties of AC in compression and potential role in the etiology of OA. We hypothesize that despite increased proteoglycan biosynthesis, disruption of the mineralized zone of AC impacts the mechanical properties of cartilage that function to accommodate loads and that therapeutic restoration of this zone will improve the mechanical properties of AC. Data were compared between three groups: wild type (WT), Hyp, and Hyp mice treated with calcitriol and oral phosphate. EPIC microCT confirmed AC mineral deficits and responsiveness to therapy. MicroCT of the Hyp subchondral bone plate revealed that treatment improved trabecular bone volume (BV/TV) but remained significantly lower than WT mice in other trabecular microstructures (p < 0.05). Microindentation AC studies revealed that, compared with WT mice, the mean stiffness of tibial AC was significantly lower in untreated Hyp mice (2.65 ± 0.95 versus 0.87 ± 0.33 N/mm, p < 0.001) and improved with therapy (2.15 + 0.38 N/mm) to within WT values. Stress relaxation of AC under compressive loading displayed similar biphasic relaxation time constants (Taufast and Tauslow) between controls and Hyp mice, although Tauslow trended toward slowed relaxation times. In addition, Taufast and Tauslow times correlated with peak load in WT mice (r = 0.80; r = 0.78, respectively), whereas correlation coefficient values for Hyp mice (r = 0.46; r = 0.21) improved with treatment (r = 0.71; r = 0.56). These data provide rationale for therapies that both preserve AC stiffness and recovery from compression. The Hyp mouse also provides unique insight into determinants of structural stiffness and the viscoelastic properties of AC in the progression of OA. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts‐induced BEAS‐2B cells by modulating MMP‐9/TIMP‐1 signaling
Authors: Xu Wei , Li Fuqiang , Zhu Lihong , Cheng Mingliang , Cheng Yiju 
Published: July 2023

AbstractChronic obstructive pulmonary disease (COPD) has high morbidity and mortality. Here, we aimed to explore the roles and potential correlation of placenta polypeptide injection (PPI) and MMP‐9/TIMP‐1 signaling pathway in COPD. BEAS‐2B cells were treated with cigarette smoke extract (CSE) to establish a COPD cell model in vitro. The cell survival and cytotoxic effect were measured by CCK‐8, LDH release and flow cytometry assays. The inflammatory responses were determined by western blot and ELISA assay. Cell fibrosis was assessed by immunofluorescence and western blot assays. PPI treatment had no cytotoxic effect on BEAS‐2B cells until the final concentration reached to 10%. In the range of 0%–8% final concentration, PPI treatment weakened CSE‐induced the decrease of cell viability and the increase of LDH level in a concentration‐dependent manner. Four percent PPI treatment enhanced cell viability and decreased cell apoptosis of CSE‐treated cells in a time‐dependent manner. Moreover, 4% PPI treatment significantly decreased inflammatory responses and fibrosis induced by CSE, while AMPA (MMPs agonist) had opposite effects. Notably, AMPA reversed the protective roles of PPI on CSE‐induced inflammation and fibrosis. Mechanistically, 4% PPI treatment significantly suppressed MMP‐1, MMP‐2, MMP‐3, MMP‐9, MMP‐13, and MMP‐19 levels, but enhanced TIMP‐1, TIMP‐2, TIMP‐3, and TIMP‐4 levels. Among them, MMP‐9 and TIMP‐1 might be the main target of PPI. PPI effectively attenuated CSE‐induced inflammation and fibrosis in vitro by regulating MMP‐9/TIMP‐1 signaling pathway.
From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers
Authors: Curieses Andrés Celia María , Pérez de la Lastra José Manuel , Andrés Juan Celia , Plou Francisco J. , Pérez‐Lebeña Eduardo 
Published: July 2023

AbstractThe influence of modern lifestyle, diet, exposure to chemicals such as phytosanitary substances, together with sedentary lifestyles and lack of exercise play an important role in inducing reactive stress (RS) and disease. The imbalance in the production and scavenging of free radicals and the induction of RS (oxidative, nitrosative, and halogenative) plays an essential role in the etiology of various chronic pathologies, such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. The implication of free radicals and reactive species injury in metabolic disturbances and the onset of many diseases have been accumulating for several decades, and are now accepted as a major cause of many chronic diseases. Exposure to elevated levels of free radicals can cause molecular structural impact on proteins, lipids, and DNA, as well as functional alteration of enzyme homeostasis, leading to aberrations in gene expression. Endogenous depletion of antioxidant enzymes can be mitigated using exogenous antioxidants. The current interest in the use of exogenous antioxidants as adjunctive agents for the treatment of human diseases allows a better understanding of these diseases, facilitating the development of new therapeutic agents with antioxidant activity to improve the treatment of various diseases. Here we examine the role that RS play in the initiation of disease and in the reactivity of free radicals and RS in organic and inorganic cellular components.
Systematic review and meta‐analysis on the serological, immunological, and cardiac parameters of the multisystem inflammatory syndrome (MIS‐C) associated with SARS‐CoV‐2 infection
Authors: Ghazizadeh Esslami Golnaz , Mamishi Setareh , Pourakbari Babak , Mahmoudi Shima 
Published: July 2023

AbstractDiverse clinical and laboratory features of multisystem inflammatory syndrome (MIS‐C) have been reported in the literature. Despite the worldwide distribution, systemic studies regarding the laboratory results do not exist. Therefore, we aimed to perform this systematic review and meta‐analysis to evaluate the serological, immunological, and cardiac parameters of the MIS‐C associated with SARS‐CoV‐2 infection. We searched the PubMed, Scopus, and Web of Science databases using specific keywords for any papers published in English since the disease onset and the first report until July 19, 2020. The inclusion criteria were children <21 years diagnosed with MIS‐C without any limitation on defining criteria. Forty‐eight studies were included in the final analysis, with a total population size of 3543 children with MIS‐C. The median age of the included patients was 8.3 (6.7–9) years. The pooled prevalence of male patients was 59% (95% CI: 56%–61%) and 62% (95% CI: 55%–69%) were admitted in ICU. The pooled prevalence of positive SARS‐CoV‐2 RT‐PCR, SARS‐CoV‐2 IgM, and SARS‐CoV‐2 IgG antibody tests was 33% (95% CI: 27%–40%), 39% (95% CI: 22%–58%) and 81% (95% CI: 76%–86%), respectively. The positivity rate of the inflammatory markers was as follows: CRP (96%, 95% CI: 90%–100%), d‐dimer (87%, 95% CI: 81%–93%), ESR (81%, 95% CI: 74%–87%), procalcitonin (88%, 95% CI: 76%–97%), ferritin (79%, 95% CI: 69%–87%), and fibrinogen (77%, 95% CI: 70%–84%). The pooled prevalence of elevated brain natriuretic peptide (BNP) level, pro‐BNP, and troponin were found in 60% (95% CI: 44%–75%), 87% (95% CI: 75%–96%), and 55% (95% CI: 45%–64%), respectively. The majority of patients had positive SARS‐CoV‐2 IgG test. Nearly one‐third of the cases showed negative RT‐PCR results. Cardiac and inflammatory markers were elevated in the majority of cases. These findings suggest that hyperinflammation and cardiac dysfunction are common complications of MIS‐C.
Development a novel nomogram model for predicting significant hepatic histological changes in chronic hepatitis B virus carriers
Authors: Kang Na‐Ling , Gao Ya‐Hong , Lin Meng‐Xin , Wu Lu‐Ying , Ye Xiang‐Yang , Lin Hui‐Ming , Ruan Qing‐Fa , Lin Shuo , Liu Hao‐Hang , Huang Ling‐Ling , Jiang Jia‐Ji , Liu Yu‐Rui , Zheng Qi , Mao Ri‐Cheng , Zeng Da‐Wu 
Published: July 2023

AbstractA proportion of chronic hepatitis B virus (HBV) carriers with normal alanine transaminase (ALT) present with significant liver histological changes (SLHC). To construct a noninvasive nomogram model to identify SLHC in chronic HBV carriers with different upper limits of normal (ULNs) for ALT. The training cohort consisted of 732 chronic HBV carriers who were stratified into four sets according to different ULNs for ALT: chronic HBV carriers I, II, III, and IV. The external validation cohort comprised 277 chronic HBV carriers. Logistic regression and least absolute shrinkage and selection operator analyses were applied to develop a nomogram model to predict SLHC. A nomogram model‐HBGP (based on hepatitis B surface antigen, gamma‐glutamyl transpeptidase, and platelet count) demonstrated good performance in diagnosing SLHC with area under the curve (AUCs) of 0.866 (95% confidence interval [CI]: 0.839−0.892) and 0.885 (95% CI: 0.845−0.925) in the training and validation cohorts, respectively. Furthermore, HBGP displayed high diagnostic values for SLHC with AUCs of 0.866 (95% CI: 0.839−0.892), 0.868 (95% CI: 0.838−0.898), 0.865 (95% CI: 0.828−0.901), and 0.853 (95% CI: 0.798−0.908) in chronic HBV carriers I, II, III, and IV, respectively. Additionally, HBGP showed greater ability in predicting SLHC compared with the existing predictors. HBGP has shown high predictive performance for SLHC, and thus may lead to an informed decision on the initiation of antiviral treatment.
Microbial‐driven carbon fixation in natural wetland
Authors: Li Yanmei , Xiong Lingling , Zeng Kun , Wei Yunlin , Li Haiyan , Ji Xiuling 
Published: July 2023

AbstractWith the development of global industrialization, carbon neutrality has become an issue that we must be paid attention to. Microorganisms not only have an important impact on the carbon chemical cycle between the Earth's biosphere and biogeography but also play a key role in maintaining the global organic carbon balance. Wetlands are the main reservoir of organic carbon in the mainland of China, and wetland carbon sinks are indispensable for China to achieve the goal of “dual carbon,” and China has taken the consolidation and improvement of wetland carbon sink capacity as an important part of the carbon peaking action plan. As a unique low‐latitude, high‐altitude seasonal plateau wetland in China, Napahai shows high research value. However, the role of microbes in maintaining dissolved organic carbon balance in this area has not been reported. In the study, six carbon fixation genes, accA, aclB, acsA, acsB, cbbL, and rbcL, were analyzed based on metagenomics to elucidate the rich genetic diversity, uniqueness and differences in the Napahai plateau wetland. It was found that the microbial diversity in the Napahai plateau wetland was different from other habitats. In addition, the aclB gene, a rare taxon with high genetic diversity and rich species in the Napahai plateau wetland, played a key role in the microbial metabolic pathway. Finally, the construction of a metabolic pathway through the Kyoto encyclopedia for genes and genomes revealed the contribution of microbes to carbon fixation and the role of microbes in maintaining the organic carbon balance of the Napahai plateau wetland.
Multimodality imaging of hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Authors: Shahbazian Haneyeh , Mirza‐Aghazadeh‐Attari Mohammad , Borhani Ali , Mohseni Alireza , Madani Seyedeh Panid , Ansari Golnoosh , Pawlik Timothy M. , Kamel Ihab R. 
Published: July 2023

AbstractHepatocellular carcinoma and intrahepatic cholangiocarcinoma are the two most common primary malignant tumors of the liver. The similarities and variations in imaging characteristics that may aid in distinguishing between these two primary tumors will be discussed and outlined in this review. Knowledge of imaging techniques that are currently available would assist in the differentiation between these primary malignancies.
A Medicare Physician Fee Schedule Analysis of Reimbursement Trends in Laryngology from 2000 to 2021
Authors: Xu James R. , Lorenz Robert R. , Mulligan Kathleen M. , Otteson Todd D. , Maronian Nicole C. , Manes R. Peter , Lerner Michael Z. , Bryson Paul C. 
Published: July 2023

ObjectiveThe purpose of this study is to characterize Medicare reimbursement trends for laryngology procedures over the last two decades.MethodsThis analysis used CMS' Physician Fee Schedule (PFS) Look‐Up Tool to determine the reimbursement rate of 48 common laryngology procedures, which were divided into four groups based on their practice setting and clinical use: office‐based, airway, voice disorders, and dysphagia. The PFS reports the physician service reimbursement for “facilities” and global reimbursement for “non‐facilities”. The annual reimbursement rate for each procedure was averaged across all localities and adjusted for inflation. The compound annual growth rate (CAGR) of each procedure's reimbursement was determined, and a weighted average of the CAGR for each group of procedures was calculated using each procedure's 2020 Medicare Part B utilization.ResultsReimbursement for laryngology procedure (CPT) codes has declined over the last two decades. In facilities, the weighted average CAGR for office‐based procedures was −2.0%, for airway procedures was −2.2%, for voice disorders procedures was −1.4%, and for dysphagia procedures was −1.7%. In non‐facilities, the weighted average CAGR for office‐based procedures was −0.9%. The procedures in the other procedure groups did not have a corresponding non‐facility reimbursement rate.ConclusionLike other otolaryngology subspecialties, inflation‐adjusted reimbursements for common laryngology procedures have decreased substantially over the past two decades. Because of the large number of physician participants and patient enrollees in the Medicare programs, increased awareness and further research into the implications of these trends on patient care is necessary to ensure quality in the delivery of laryngology care.Level of EvidenceNA Laryngoscope, 134:247–256, 2024
The structural characteristics and driving mechanism of collaborative innovation network for saline–alkali land development in China
Authors: Yanmei Wang , Yusheng Chen , Zhaofa Sun , Wenjie Sun 
Published: July 2023

AbstractIt is challenging for a single development subject to complete complex scientific research tasks due to the peculiarities of saline–alkali land. Collaborative innovation and cooperation can help break through the common critical technology R&D problems in the development process by sharing information, technology, knowledge, and resources. However, the process of saline–alkali land development in China is slow and the transformation rate of research results is low. Few articles analyze the current situation and driving mechanism of the collaborative innovation network for saline–alkali land development from the perspective of the innovation chain. This paper first constructs an undirected weighted collaborative innovation network from the upstream, midstream, and downstream levels of technological innovation for saline–alkali land development, analyzing the network's structural characteristics and spatial distribution features. Then uses ERGM to explore the internal and external driving mechanism for network formation from network self‐organization, subject characteristics, and exogenous environmental factors. The results demonstrate that the distribution of the collaborative innovation network is relatively uniform. However, there are also clusters, and the clusters are mostly centered on universities and scientific research institutions. Both the development subjects and clusters present regional features. Centrality and transitivity are crucial to the internal driving mechanism. In the external driving mechanism, the Matthew effect is modest, and the homogeneity effect is considerable; Organizational and technical proximity play a positive role; Geographical and institutional proximity play a blocking role. This study also provides practical enlightenment for encouraging horizontal and vertical collaborative innovation of sustainable development of saline–alkali land.
Efficacy evaluation of newly isolated zinc solubilizing bacteria for their potential effect on maize (Zea mays L.) under zinc deficient soil conditions
Authors: Sukhwal Aradhana , Jain Devendra , Sharma Vimal , Ojha S. N. , Jat Gajanand , K. Upadhyay Sudhir , Singh Abhijeet , Mohanty Santosh Ranjan 
Published: July 2023

AbstractZinc solubilizing bacteria (ZSB) induces the conversion of fixed and unavailable soil zinc to readily available zinc contributes plant zinc nutrition and fortification. The present research intended to determine the screening of plant growth‐promoting (PGP) traits of potent ZSB, biochemical and molecular characterization of ZSB, and assessment of potent ZSB for crop yield at the field level. Therefore, in the present study, molecular and functional characterization of native ZSB isolates was done to examine their response to plant growth performance and yield, mobilization of zinc, and acquisition by maize plants. Zinc solubilizing bacterial isolates namely, ZSB1, and ZSB 17 were solubilized insoluble zinc namely, ZnCO3, ZnO, Zn3(PO4)2 and significantly induced growth performance of maize crop at field conditions. A biochemical study revealed that both ZSB isolates were positive for catalase and urease production. Isolates ZSB1 & ZSB17 showed different PGP attributes like production of Indole‐3‐acetic acid (IAA), siderophore, NH3, and HCN. Both isolates were solubilized phosphate, potassium, and silica and showed 1‐aminocyclopropane‐1‐carboxylate (ACC)‐deaminase activity. 16S rRNA amplification and sequence study of ZSB1 and ZSB17 revealed that both the isolates were Cupriavidus sp. and Pantoea agglomerans, respectively, and novel. The results elucidated from pot studies demonstrated that both ZSB1 & ZSB17 were the more suitable isolates than other ZSB isolates, and these isolates were further tested for field studies. Cupriavidus sp. and Pantoea agglomerans strains increased Zn‐translocation toward grains and yield of Maize (cv: P3441) by 19.01% and 17.64%, respectively. We conclude that the novel indigenous ZSB strains substantially heightened zinc mobilization, the yield of maize crop, restore soil health, and can be suitable for biofortification and biofertilizers technology.
Depth profiles of Jerlov water types
Authors: Williamson Craig A. , Hollins Richard C. 
Published: July 2023

AbstractTypical depth profiles of Jerlov water types have been derived to characterize the clarity of the world's oceans. Measured values of the downwelling diffuse attenuation coefficient, taken from a world‐wide database, were quantitatively analyzed. Depth profiles were extracted from more than 2500 data collection campaigns, consisting of the closest‐matching Jerlov water types at the uppermost layer (0–10 m) and the corresponding Jerlov water types at deeper depth layers down to 200 m. A table of “typical” depth profiles for the 10 Jerlov water types was generated based on the maximum campaign count at each depth layer. This new ocean classification will find use in applications where modeling of typical ocean waters requires the depth‐dependence of clarity to be accounted for.
Microwave Plasmonic Exceptional Points for Enhanced Sensing
Authors: Liao Zhen , Peng Xing , Liu, Leilei , Xu Yihao , Xu Kai‐Da , Pan Baicao , Luo, Guo Qing , Liu Yongmin 
Published: July 2023

AbstractThe emergence of exceptional points in a non‐Hermitian system has provided intriguing possibilities to enhance the sensitivity of a sensor, while it is yet a considerable challenge to implement subwavelength non‐Hermitian systems. One possible solution to tackle this challenge is to take advantage of localized surface plasmon resonances, which enable large electromagnetic enhancement at the subwavelength scale. In this work, a novel sensing scheme based on the exceptional points in a spoof plasmonic structure working at microwave frequencies is proposed. It is shown that near‐field plasmonic vortices can be efficiently generated at the exceptional points, resulting in the enhanced sensitivity when detecting a single particle or fluid analytes. Single particle detection with the particle size as small as 1/100 of the operating wavelength is reported. For liquid analysis in the microfluidic system, the sample consumption is down to 0.72 μL. This work demonstrates the ultrahigh sensitivity of exceptional‐point‐based plasmonic sensing and opens up new possibilities for subwavelength and compact sensors operating in the microwave, terahertz, and even far‐infrared regions.