bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation
Authors: Algharably Engi Abdelhady , Di Consiglio Emma , Testai Emanuela , Pistollato Francesca , Bal-Price Anna , Najjar Abdulkarim , Kreutz Reinhold , Gundert-Remy Ursula 
Published: March 2023

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied quantitative in vitro–in vivo extrapolation (QIVIVE) based on in vitro concentration and non-choline esterase-dependent effects data combined with Benchmark dose (BMD) modelling to predict oral maternal CPF exposure during pregnancy leading to fetal brain effect concentration. By comparing the results with data from epidemiological studies, we evaluated the contribution of the in vitro endpoints to the mode of action (MoA) for CPF-induced DNT.Methods: A maternal-fetal PBK model built in PK-Sim® was used to perform QIVIVE predicting CPF concentrations in a pregnant women population at 15 weeks of gestation from cell lysate concentrations obtained in human induced pluripotent stem cell-derived neural stem cells undergoing differentiation towards neurons and glia exposed to CPF for 14 days. The in vitro concentration and effect data were used to perform BMD modelling.Results: The upper BMD was converted into maternal doses which ranged from 3.21 to 271 mg/kg bw/day. Maternal CPF blood levels from epidemiological studies reporting DNT findings in their children were used to estimate oral CPF exposure during pregnancy using the PBK model. It ranged from 0.11 to 140 μg/kg bw/day.Discussion: The effective daily intake doses predicted from the in vitro model were several orders of magnitude higher than exposures estimated from epidemiological studies to induce developmental non-cholinergic neurotoxic responses, which were captured by the analyzed in vitro test battery. These were also higher than the in vivo LOEC for cholinergic effects. Therefore, the quantitative predictive value of the investigated non-choline esterase-dependent effects, although possibly relevant for other chemicals, may not adequately represent potential key events in the MoA for CPF-associated DNT.
Urea derivative MTU improves stress tolerance and yield in wheat by promoting cyclic electron flow around PSI
Authors: Nisler Jaroslav , Kučerová Zuzana , Koprna Radoslav , Sobotka Roman , Slivková Jana , Rossall Stephen , Špundová Martina , Husičková Alexandra , Pilný Jan , Tarkowská Danuše , Novák Ondřej , Škrabišová Mária , Strnad Miroslav 
Published: March 2023

Increasing crop productivity under optimal conditions and mitigating yield losses under stressful conditions is a major challenge in contemporary agriculture. We have recently identified an effective anti-senescence compound (MTU, [1-(2-methoxyethyl)-3-(1,2,3-thiadiazol-5yl)urea]) in in vitro studies. Here, we show that MTU delayed both age- and stress-induced senescence of wheat plants (Triticum aestivum L.) by enhancing the abundance of PSI supercomplex with LHCa antennae (PSI-LHCa) and promoting the cyclic electron flow (CEF) around PSI. We suppose that this rarely-observed phenomenon blocks the disintegration of photosynthetic apparatus and maintains its activity as was reflected by the faster growth rate of wheat in optimal conditions and under drought and heat stress. Our multiyear field trial analysis further shows that the treatment with 0.4 g ha-1 of MTU enhanced average grain yields of field-grown wheat and barley (Hordeum vulgare L.) by 5-8%. Interestingly, the analysis of gene expression and hormone profiling confirms that MTU acts without the involvement of cytokinins or other phytohormones. Moreover, MTU appears to be the only chemical reported to date to affect PSI stability and activity. Our results indicate a central role of PSI and CEF in the onset of senescence with implications in yield management at least for cereal species.
The therapeutic effects of attending a one-day outpatient service on patients with gestational diabetes and different pre-pregnancy body mass indices
Authors: Cao Yan-Min , Ma Min , Wang Wei , Cai Na-Na 
Published: March 2023

PurposeThis study investigated the effects of attending a one-day outpatient service on the outcomes of patients with gestational diabetes mellitus (GDM) and different pre-pregnancy body mass indices (BMIs).MethodsThe study recruited 311 pregnant women with GDM into a one-day outpatient service at The Fourth Hospital of Shijiazhuang from September 2019 to December 2021. They were randomly assigned to three groups, based on their pre-pregnancy BMI as follows: group A, BMI &lt; 18.5 kg/m2; group B, 18.5 ≥ BMI &gt; 25.0 kg/m2; group C, BMI ≥25 kg/m2. The following information was collected from all the participants: fasting blood glucose, hemoglobin A1c (HbA1C), insulin dose, gestational weight gain, weight gain after the one-day outpatient service, and perinatal outcomes.ResultsThe three groups showed significant differences in fasting blood glucose and HbA1C, insulin treatment rate, and the incidence of pregnancy hypertension/preeclampsia and neonatal jaundice (all P &lt; 0.05). The rate of excessive gestational weight gain in all of the groups also reflected significant differences (P &lt; 0.05). Group A showed the lowest weight gain, while group C gained the most weight. There is no significant difference in the incidences of hypertension/preeclampsia, neonatal jaundice, or premature birth between patients with weight loss/no weight gain and those with positive weight gain.ConclusionOne-day diabetes outpatient integrated management may effectively help to manage weight gain and blood glucose in patients with GDM and different pre-pregnancy BMIs. Dietary control after a GDM diagnosis may have helped to avoid weight gain entirely, as well as negative weight gain, but did not increase the risk of maternal and infant-related complications.
Emergency medical service personnel' post-traumatic stress disorder and psychological detachment: The mediating role of presenteeism
Authors: Liao Dandan , Long Yanqiong , Yu Tao , Kang Xiaoyan , Liu Shulai , Yan Jin , Zhang AiDi 
Published: March 2023

BackgroundEmergency medical service personnel are subjected to various stressors, which makes them more likely to develop post-traumatic stress disorder symptoms. Studies have shown that psychological detachment and presenteeism play a role at the level of post-traumatic stress disorder. There is no study to examine the relationship between psychological detachment, presenteeism, and post-traumatic stress disorder among emergency medical service personnel.ObjectiveThe main objective of the study is to investigate the effects of presenteeism in explaining the relationship between psychological detachment and post-traumatic stress disorder among emergency medical service personnel.DesignA cross-sectional study was conducted among 836 emergency medical service personnel in 51 counties and cities in Hunan Province, China.MethodsThey were anonymously investigated by using the Impact of Event Scale-Revised (IES-R), the Stanford Presenteeism scale-6 (SPS-6), and the Psychological Detachment Scale. Statistic description, univariate analysis, pearson correlation, and structural equation model were adopted to analyze the data.ResultsThe mean score of IES-R, SPS-6, and the psychological detachment scale were 22.44 ± 16.70, 15.13 ± 4.20, and 11.30 ± 4.24. Post-traumatic stress disorder was positively relevant with presenteeism (r = 0.381, p&lt; 0.01), but negatively correlated with psychological detachment (r = −0.220, p &lt; 0.01). And presenteeism partially mediated the association between psychological detachment and post-traumatic stress disorder.ConclusionsThe results show a high prevalence of post-traumatic stress disorder symptoms in EMS personnel, presenteeism can statistically significantly predict post-traumatic stress disorder symptoms. If hospital management can reduce the presenteeism of emergency medical service personnel, this will help them reduce post-traumatic stress disorder symptoms.
Impact of the COVID pandemic on mental health and training opportunities of Public Health Residents from 4 European countries: A cross-sectional study
Authors: Failla Giovanna , Caminiti Marta , Chen-Xu José , Lo Moro Giuseppina , Berselli Nausicaa , Cabral Ferreira Madalena , Malcata Filipa , Peyre-Costa David , Croci Roberto , Soldà Giorgia , Capodici Angelo , Morcavallo Caterina , Traglia Francesco , Cedrone Fabrizio , Storti Ilaria , Jaquete Alfonso Alonso , Antinozzi Martina , Vasiliu Anca 
Published: March 2023

ObjectivesThere is little evidence on the impact of the COVID-19 pandemic on Public Health Residents' (PHR) mental health (MH). This study aims at assessing prevalence and risk factors for depression, anxiety and stress in European PHR during the COVID-19 pandemic.MethodsBetween March and April 2021, an online survey was administered to PHR from France, Italy, Portugal and Spain. The survey assessed COVID-19 related changes in working conditions, training opportunities and evaluated MH outcomes using the Depression Anxiety Stress Scales-21. Multivariable logistic regressions were applied to identify risk factors.ResultsAmong the 443 respondents, many showed symptoms of depression (60.5%), anxiety (43.1%) and stress (61.2%). The main outcome predictors were: female gender for depression (adjOR = 1.59, 95%CI [1.05–2.42]), anxiety (adjOR = 2.03, 95%CI [1.33–3.08]), and stress (adjOR = 2.35, 95%CI [1.53–3.61]); loss of research opportunities for anxiety (adjOR = 1.94, 95%CI [1.28–2.93]) and stress (adjOR = 1.98, 95%CI [1.26–3.11]); and COVID-19 impact on training (adjOR = 1.78, 95%CI [1.12–2.80]) for depression.ConclusionsThe pandemic had a significant impact on PHR in terms of depression, anxiety and stress, especially for women and who lost work-related opportunities. Training programs should offer PHR appropriate MH support and training opportunities.
Research on the establishment of evaluation index system of the aging construction of the community
Authors: Li Kun , Mei Wen-Bing , Huang Yi-Zhe 
Published: March 2023

IntroductionConstructing the evaluation index system for the community's aging-friendly construction can provide a decision-making basis for the overall investment and priority satisfaction strategy for the community's aging-friendly construction.MethodsThrough questionnaire survey and statistical analysis, this paper evaluates and analyzes the satisfaction level of various indicators of the community's aging-friendly construction.ResultsThe results show that the community's humanistic care, public environment, and socio-economic criteria are significantly linearly linked to the overall construction satisfaction level. There are significant differences in the general satisfaction level of older adults in the variables of “age, educational background, residence duration, residence personnel, number of children, and marital status”.DiscussionTo this end, the article concludes with specific recommendations that improving older-adult care services for older adults with low age and high education, helping older adults in the community to familiarize themselves with the community environment as soon as possible, cultivating the professional abilities of community service personnel, reflecting the warmth of the community for older-adult care and improving social security capabilities are the core content of the future community building for aging.
Particulate matter exposure in construction sites is associated with health effects in workers
Authors: Sekhavati Eghbal , Yengejeh Reza Jalilzadeh 
Published: March 2023

BackgroundExposure to suspended particulate matters (PMs) at high concentrations, mainly observed in the construction workplace, is found to be a risk factor for major health outcomes. The present study was conducted to investigate the degree of exposure to suspended PMs in different stages of construction of the buildings and the health risk associated with the exposure in Lar, Fars, Iran.MethodsIn this cross-sectional study, two construction sites were selected in Lar. Cancer and non-cancer health risks of exposure to PM2.5 and PM10 were assessed using the US Environmental Protection Agency method in three-dimensions: inhalation, digestion, and dermal absorption. The hazard quotient (HQ) and total cancer risk (TCR) were considered as parameters for risk analysis.ResultsThe highest level of non-cancer risk for workers in the concentrations of PM2.5 and PM10 particles in the drilling process were determined to be 2.97 × 10−1 and 8.52 × 10−2, respectively. In the cancer risk analysis, PM10 concentrations were estimated to be at the highest level (1.7 × 10−7) in the drilling process and the lowest level (4.29 × 10−8) in the facilities process. For suspended PM2.5, it was an unacceptable risk level in all processes, except for the implementation of facilities.ConclusionThese results show that the construction industry, especially in developing countries such as Iran, needs better management to maintain the health of construction workers.
The impacts of public hospital comprehensive reform policies on hospital medicine cost, revenues and healthcare expenditures 2014–2019: An analysis of 103 tertiary public hospitals in China
Authors: Pan Lin , Xiao Kai , Zhu Huanhuan , Luo Li 
Published: March 2023

ObjectiveTo explore the impact of implementation of the comprehensive public hospital reform policy (CPHRP) on medicine costs, revenues and medical expenditures in tertiary public hospitals in China.MethodsThe data of this study was collected from local administrations to obtain operational data of healthcare institutions and medicine procurement data for 103 tertiary public hospitals from 2014 to 2019. The propensity matching score method and the difference-in-difference method were used jointly to assess the impact of reform policies on tertiary public hospitals.ResultsAfter the implementation of the policy, drug revenue in the intervention group decreased by ¥ 86.3 million (p = 0.076) compared to the control group; medical service revenue increased by ¥ 108.5 million (p &lt; 0.001); government financial subsidies increased by ¥ 20.3 million (p = 0.085); the average medicine cost per outpatient and emergency visit decreased by ¥ 15.2 (p = 0.062); the average medicine cost per hospitalization decreased by ¥ 504 (p = 0.040); however, the medicine cost decreased by ¥ 38.2 million (p = 0.351), the average cost per visit for outpatient and emergency decreased by ¥ 0.562 (p = 0.966), the average cost per hospitalization decreased by ¥ 152 (p = 0.844), which are not significant.ConclusionsThe implementation of reform policies has changed the revenue structure of public hospitals; the proportion of drug revenue decreased, while the proportion of service income increased, especially in service income and government subsidies. Meanwhile, the average medicine cost of outpatient, emergency, and inpatient visits per time were all reduced, which played a certain role in reducing the disease burden of patients.
De internato a assentamento: um panorama do desenvolvimento rural sustentável em batatais através do assentamento nossa terra
Authors: Donda Arianne Caus , Fonseca Denis Cezar , Da Silva Rodolfo de Tarso , Prado Vinicius Amorim 
Published: March 2023

Este artigo analisou dentro de uma perspectiva temática da política pública e de desenvolvimento rural sustentável o Assentamento Nossa Terra, localizado no interior de São Paulo. O assentamento Nossa Terra foi implantado em 239,765 hectares por meio do decreto Nº 49.416 de 23 de fevereiro de 2005, que estabeleceu a transferência da administração da Fundação Estadual do Bem-Estar do Menor (FEBEM-SP) para a Secretaria da Justiça e da Defesa da Cidadania e, com isso, permitiu a utilização da área pela Fundação Instituto de Terras do Estado de São Paulo. Neste sentido, este estudo analisou conceitos como: cluster, complexo agroindustrial, cadeia produtiva e ainda o arranjo produtivo local para discutir as principais características do assentamento. Analisou também os stakeholders envolvidos na implantação do assentamento e o planejamento estratégico para mostrar a importância do Zoneamento Ecológico-Econômico (ZEE), para o Brasil e no estado de São Paulo. A metodologia utilizada foi a pesquisa documental, através de uma análise da Lei 6.938 de 31 de Agosto de 1981; o Decreto 4.297 que trata do ZEE, como instrumento da Política Nacional do Meio Ambiente; O Plano Diretor do Município de Batatais; O Plano Municipal do Desenvolvimento Agropecuário Plurianual de São Paulo 2014-2017 e sites do governo federal, estadual e municipal que foram usados para consultas e coletas de dados. A pesquisa demonstrou que o assentamento em questão pode vir a contribuir com o desenvolvimento rural sustentável tendo o ZEE como uma possível alavanca para a sustentabilidade da cidade de Batatais no interior paulista. O ZEE mostrou-se como um importante instrumento para a elaboração de políticas e decisões públicas, estabelecendo indicadores que possibilitam que seja realizada a avaliação e o monitoramento das políticas e ações públicas nas zonas ambientais sendo aliado a um plano diretor institucionalizado. Ambos os instrumentos podem servir de alavanca para as diversas áreas do município, principalmente para o desenvolvimento econômico e desenvolvimento sustentável, importantíssimos para o atual momento que o nosso planeta enfrenta.
Sostenibilidad empresarial y la gestión de recursos humanos: un análisis comparativo entre las pequeñas y medianas empresas de Lagos de Moreno y La Zona Metropolitana de Guadalajara, Jalisco
Authors: Navarrete-Báez Francisco Ernesto , Medina Ana Maria Macias 
Published: March 2023

En este trabajo se muestra prácticas de sostenibilidad empresarial a través de la gestión del área de recursos humanos (RRHH) de las pequeñas y medianas empresas (PYME) en cuanto a su representatividad en la dirección de prácticas de desarrollo sustentable empresarial, que incluye tres categorías: la integración de prácticas de RRHH, las implicaciones que éstas generan, y los motivos por lo cual los empresarios las llevan a cabo. Se hizo un análisis comparativo entre una muestra de PYME ubicadas en la ciudad de Lagos de Moreno, y otras ubicadas en la Zona Metropolitana de Guadalajara (ZMG), ambas en el estado de Jalisco, México, debido a estar ubicadas dentro de uno los polos de más desarrollo económicos del país, lo que implica una gran competencia entre sí. Aplicando un cuestionario de desarrollo propio que incluyó 15 preguntas sobre el tema. Se hizo uso de la estadística tanto descriptiva como inferencial, utilizando la herramienta de análisis de la varianza ANOVA. Donde se planteó si es determinante el impacto en el desarrollo sustentable de esta gestión de RRHH en estas empresas. Se encontró que no hubo diferencia significativa entre las empresas de ambas regiones, y que, en algunas variables analizadas, la región de Lagos de Moreno estuvo por arriba que la de la ZMG.
Simulation of Shrouded Wind Turbine Performance
Authors: Elbakry Hossam , Attia Ahmed 
Published: March 2023

<p>The objective of this research is to enhance the diffuser parameters of shrouded Wind Turbine (Diffuser Augmented Wind Turbine DAWT). The study investigates different parameters of diffuser shape like inlet shroud curvature, diffuser flange height and the downstream splitter open angle. The focus on these parameters are to develop the optimum condition of diffuser parameters for the aspect of power and thrust force coefficients. For that purpose, two diffuser cases have been recommended as an effective design in increasing wind speed in the literature. In addition to the two diffuser cases, a simulated model of wind turbine designed using blade element momentum (BEM) technique and has been validated with a Wind Turbine (AMPAIR-300). Each case has been simulated and analyzed using design software Solid-works and Computational Fluid Dynamic (CFD) Software Fluent-ANSYS-15. As per the study, for diffuser case-1, the diffuser splitter degrades the diffuser effect and not recommended as a tool of power augmentation, also adding inlet shroud directs the wind flow into the inlet of diffuser and the diffuser flange effect on the power enhancement was significant and also its induced axial load was significant, and it is recommended to use the splitter at the area downstream of the diffuser surface and to modify the diffuser shroud shape to decreases the axial thrust effect with enhancing the power coefficient. </p>
الصورة الذهنية عن كلية التمريض في جامعة الكوفة لدى طلبة المرحلة الرابعة
Authors: الخياط حسام 
Published: March 2023

إن الصورة الذهنية تحدد وترسم ملامح وسمات الأشخاص والمؤسسات والدول، ويتوقف ضعف او قوة هذه الصورة على طبيعة اتصال الأفراد مع المؤسسة أو الدولة أو الأشخاص، فمن خلال هذا الاتصال يمكن تحديد الصورة الذهنية تجاه الأشياء، تمثلت المشكلة البحثية للبحث المعنون بـ( الصورة الذهنية عن كلية التمريض في جامعة الكوفة لدى طلبة المرحلة الرابعة ) في تحديد ملامح هذه الصورة لدى الطلبة، وتتمثل أهداف البحث بالوقوف على مدى اهتمام الكلية بطلبتها، وتحديد مدى الفائدة العلمية التي حققها الطلبة خلال دراستهم، ومعرفة كفاءة الملاك التدريسي، والسمعة العلمية التي تتمتع بها الكلية ، ويعد هذا البحث من البحوث الوصفية، إذ اعتمد فيه الباحث على المنهج المسحي باستخدام أداة الاستبانة، كما تحدد مجتمع البحث بطلبة المرحلة الرابعة في كلية التمريض بجامعة الكوفة، وقد اعتمد الباحث على أسلوب العينة العشوائية.
وقد توصل البحث الى أن الكلية تهتم وبشكل كبير بطلبتها، كما تتمتع بسمعة علمية طيبة، وكذلك تمتلك ملاك تدريسي ذو كفاءة عالية، وكذلك تحقيق فائدة علمية خلال الدراسة فيها، وبينت النتائج بأن أغلب الطلبة لم تكن لديهم معرفة بالكلية مسبقاً، كما أن كفاءة خريجيها لم تكن عالية، مع قصور الكلية تجاه الطلبة في توفير الفرص للمشاركة في المحافل العلمية.
O entrelace do perfil do professor com a formação profissional do enfermeiro com compromisso social
Authors: Chrizostimo Miriam Marinho , Sanchez Maritza Consuelo Ortiz , Xavier Maria Lelita , Silvino Zenith Rosa , Chrizostimo Raquel Marinho 
Published: March 2023

Historicamente, a formação profissional do enfermeiro abarca campos da educação e da saúde.O problema está no perfil dos docentes de escolas de enfermagem federais para cumprimento do Projeto Pedagógico de Curso, com vista ao exercí­cio e í prática com compromisso social. Há de se justificar pelo entendimento do perfil dos professores entrelaçado com o pano de fundo que é a formação e o compromisso social. A questão norteadora: Qual é o perfil profissional dos professores que atuam na formação de enfermeiros? O objetivo é investigar o perfil profissional dos professores para abarcar a formação de enfermeiros com compromisso social. O método prevê estudo de caso realizado em 2014. Abordagem quanti-qualitativa. Aporte de Pierre Bourdieu. O resultado traz tabelas descritivas com dados quantitativos e discussão sobre aspectos obtidos a partir da entrevista. A discussão está em torno da violência simbólica e dominação masculina e a conclusão vem do compromisso social que suscita comportamento social, abarca ética e competência profissional na prática do enfermeiro docente e assistencial, a atitude profissional produzida pela estrutura social.