bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous scalarization of dyonic black hole in Einstein–Maxwell-scalar theory
Authors: Jiang Jie , Tan Jia 
Published: April 2023

AbstractIn this paper, we study the scalarization of the static and spherically symmetric dyonic Reissner–Nordstrom (RN) black holes in the Einstein–Maxwell-scalar theory where the scalar field is coupled to an electromagnetic Chern–Simons term. When both electric and magnetic charges are present, there exists an unstable region of parametric space for the dyonic RN black holes where the scalarization of black holes should occur. That is to say, mixing electric and magnetic charges can reduce the scalarization in this theory. Firstly, we calculate the perturbation field equations under the dyonic RN black hole background and obtain the corresponding asymptotic-flat perturbation solutions, which are the bifurcation points at the dyonic RN branch. The results show that the perturbation scalarization demands a lower bound of the coupling constant. Then, we calculate the scalarized black hole solutions bifurcating from the dyonic RN solutions. We find that there exist a lot of discrete branches of the scalarized solutions. Contract to the dyonic RN solutions, these scalarized solutions can be overcharged and their mass could even approach zero. After illustrating the behavior of the entropy for the scalarized black holes, we demonstrate that the scalarized configurations might be thermodynamically more stable than GR configurations. Moreover, we also show that for each scalarized branch, the black hole cannot reach the extremal limit with vanishing temperature.
Transcatheter Leadless Pacing in Children: A PACES Collaborative Study in the Real-World Setting
Authors: Shah Maully J. , Borquez Alejandro A. , Cortez Daniel , McCanta Anthony C. , De Filippo Paolo , Whitehill Robert D. , Imundo Jason R. , Moore Jeremy P. , Sherwin Elizabeth D. , Howard Taylor S. , Rosenthal Eric , Kertesz Naomi J. , Chang Philip M. , Madan Nandini , Kutalek Steven P. , Hammond Benjamin H. , Janson Christopher M. , Ramesh Iyer V. , Williams Matthew R. 
Published: April 2023

Background:
Transcatheter Leadless Pacemakers (TLP) are a safe and effective option for adults with pacing indications. These devices may be an alternative in pediatric patients and patients with congenital heart disease for whom repeated sternotomies, thoracotomies, or transvenous systems are unfavorable. However, exemption of children from clinical trials has created uncertainty over the indications, efficacy, and safety of TLP in the pediatric population. The objectives of this study are to evaluate clinical indications, procedural characteristics, electrical performance, and outcomes of TLP implantation in children.

Methods:
Retrospective data were collected from patients enrolled in the Pediatric and Congenital Electrophysiology Society TLP registry involving 15 centers. Patients ≤21 years of age who underwent Micra (Medtronic Inc, Minneapolis, MN) TLP implantation and had follow-up of ≥1 week were included in the study.

Results:
The device was successfully implanted in 62 of 63 registry patients (98%) at a mean age of 15±4.1 years and included 20 (32%) patients with congenital heart disease. The mean body weight at TLP implantation was 55±19 kg and included 8 patients ≤8 years of age and ≤30 kg in weight. TLP was implanted by femoral (n=55, 87%) and internal jugular (n=8, 12.6%) venous approaches. During a mean follow-up period of 9.5±5.3 months, there were 10 (16%) complications including one cardiac perforation/pericardial effusion, one nonocclusive femoral venous thrombus, and one retrieval and replacement of TLP due to high thresholds. There were no deaths, TLP infections, or device embolizations. Electrical parameters, including capture thresholds, R wave sensing, and pacing impedances, remained stable.

Conclusions:
Initial results from the Pediatric and Congenital Electrophysiology Society TLP registry demonstrated a high level of successful Micra device implants via femoral and internal venous jugular approaches with stable electrical parameters and infrequent major complications. Long-term prospective data are needed to confirm the reproducibility of these initial findings.
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy
Authors: Uchehara Best , Coulter Kwee Lydia , Regan Jessica , Chatterjee Ranee , Eckstrand Julie , Swope Sue , Gold Gary , Schaack Terry , Douglas Pamela , Mettu Prithu , Haddad Francois , Shore Scarlet , Hernandez Adrian , Mahaffey Kenneth W. , Pagidipati Neha , Shah Svati H. ,   on behalf of the Project Baseline Health Study Group
Published: April 2023

Background:
Epigenetic clocks estimate chronologic age using methylation levels at specific loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal values in a range of clinical, imaging, and laboratory characteristics.

Methods:

The Project Baseline Health Study recruited 2502 participants, including 1661 with epigenetic age estimates from the Horvath pan-tissue clock. We classified individuals with extreme values as having epigenetic age acceleration (EAA) or epigenetic age deceleration. A subset of participants with longitudinal methylation profiling was categorized as accelerated versus nonaccelerated. Using principal components analysis, we created phenoclusters using 122 phenotypic variables and compared individuals with EAA versus epigenetic age deceleration, and at one year of follow-up, using logistic regression models adjusted for sex (false discovery rate [
Q
] <0.10); in secondary exploratory analyses, we tested individual clinical variables.

Results:

The EAA (n=188) and epigenetic age deceleration (n=195) groups were identified as having EAA estimates ≥5 years or ≤−5 years, respectively. In primary analyses, individuals with EAA had higher values for phenoclusters summarizing lung function and lipids, and lower values for a phenocluster representing physical function. In secondary analyses of individual variables, neutrophils, body mass index, and waist circumference were significantly higher in individuals with EAA (
Q
<0.10). No phenoclusters were significantly different between participants with accelerated (n=148) versus nonaccelerated (n=112) longitudinal aging.

Conclusions:
We report multiple cardiometabolic, hematologic, and physical function features characterizing individuals with EAA. These highlight factors that may mediate the adverse effects of aging and identify potential targets for study of mitigation of these effects.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03154346.
Creativity at rest: Exploring functional network connectivity of creative experts
Authors: Orwig William , Setton Roni , Diez Ibai , Bueichekú Elisenda , Meyer Meghan L. , Tamir Diana I. , Sepulcre Jorge , Schacter Daniel L. 
Published: April 2023

Abstract
The neuroscience of creativity seeks to disentangle the complex brain processes that underpin the generation of novel ideas. Neuroimaging studies of functional connectivity, particularly functional magnetic resonance imaging (fMRI), have revealed individual differences in brain network organization associated with creative ability; however, much of the extant research is limited to laboratory-based divergent thinking measures. To overcome these limitations, we compare functional brain connectivity in a cohort of creative experts (n = 27) and controls (n = 26) and examine links with creative behavior. First, we replicate prior findings showing reduced connectivity in visual cortex related to higher creative performance. Second, we examine whether this result is driven by integrated or segregated connectivity. Third, we examine associations between functional connectivity and vivid distal simulation separately in creative experts and controls. In accordance with past work, our results show reduced connectivity to the primary visual cortex in creative experts at rest. Additionally, we observe a negative association between distal simulation vividness and connectivity to the lateral visual cortex in creative experts. Taken together, these results highlight connectivity profiles of highly creative people and suggest that creative thinking may be related to, though not fully redundant with, the ability to vividly imagine the future.
The U.S.-Mexican Border and Music as a “Border Crosser”
Authors: Hellman Judith Adler 
Published: April 2023

The ever-changing, always porous Mexican-U.S. border region has long been the site of intense and productive cultural and political exchange of every kind, particularly with respect to music. Today, mariachi performance in the United States provides a counternarrative to the discourse of anti-immigrant, anti-Mexican hate language deployed by Donald Trump and his supporters. Accordingly, the rapid spread of interest and proficiency in the production of mariachi music performed by Latino and non-Latino students in schools across the Southwest and as far northeast as New England can be thought of as a kind of social movement. Two case studies—the first a program developed by a Mexican American instructor working predominantly with Mexican American children in an overwhelmingly Anglo town in Connecticut and the second serving an ethnically diverse elementary school in Central New York State where neither the instructor nor more than a few current students are Latino—suggest the potential of this movement for breaking down ethnic and racial barriers. El siempre cambiante y siempre poroso espacio de la frontera México-Estados Unidos ha sido, durante mucho tiempo, el sitio de un intenso y productivo intercambio cultural y político de todo tipo, particularmente con respecto a la música. Hoy en día, las actuaciones de mariachis en los Estados Unidos nos brindan una contranarrativa al discurso del lenguaje de odio antiinmigrante y antimexicano desplegado por Donald Trump y sus partidarios. En consecuencia, la rápida difusión del interés y la creciente competencia en la producción de música de mariachi interpretada por estudiantes latinos y no latinos en escuelas de todo el suroeste de los Estados Unidos y tan al noreste como Nueva Inglaterra puede considerarse una especie de movimiento social. Dos estudios de caso, el primero un programa desarrollado por un instructor mexicoamericano que trabaja predominantemente con niños mexicoamericanos en una ciudad abrumadoramente anglosajona en Connecticut, y el segundo involucrando a una escuela primaria étnicamente diversa en el centro del estado de Nueva York, donde ni el instructor ni la mayor parte de los estudiantes actuales son latinos, sugieren el potencial de este movimiento para romper barreras étnicas y raciales.
Predictive role of magnetic resonance imaging in the distinction of isocitrate dehydrogenase (IDH) mutant grade 4 astrocytomas versus glioblastomas
Authors: Halefoglu Ahmet Mesrur , Camurcuoglu Eyup , Tanik Canan , Kizilkaya Orhan , Yilmaz Adem 
Published: April 2023

Background Isocitrate dehydrogenase (IDH) mutation status is a crucial prognostic factor in high-grade glial tumors. Purpose To investigate whether magnetic resonance imaging (MRI) features can display a diagnostic performance in the determination of IDH mutation in high-grade gliomas. Material and Methods A total of 170 patients including 24 IDH mutant grade 4 astrocytomas and 146 glioblastomas (GBM) were retrospectively examined via contrast-enhanced (CE) MRI before surgery. Immunohistochemistry and genomic sequence analyses were performed on specimen materials for the determination of IDH mutational status. Certain morphological and diffusion-weighted imaging (DWI) parameters were utilized to see if they could play a role to be non-invasive potential imaging predictors in the discrimination of IDH mutant versus wild-type (WT) high-grade gliomas. Results On histopathological examination, IDH mutation was detected in 24 patients with high-grade glioma and 146 of the patients were found to be WT. Certain morphological criteria of tumor location and involvement, tumor margins, visual detection of diffusion restriction on DWI, and quantitative apparent diffusion coefficient (ADC) parameters consisting of ADCmean, ADCmin, and ADCr could be used as imaging predictors in the discrimination of high-grade IDH mutant versus WT tumors. Conclusion Certain MRI morphologic features and visual detection of diffusion restriction on DWI and quantitative ADC parameters consisting of ADCmean, ADCmin, and ADCr can be considered non-invasive, significant independent imaging predictors in the discrimination and can obviate invasive procedures for histopathological diagnosis.
Floating poly(lactic-co-glycolic acid)-based controlled-release drug delivery system for intravesical instillation
Authors: Fu Kai , Zhou Yifei , Hou Jia , Shi Tao , Ni Jie , Li Xue , Zhang Hong 
Published: April 2023

Objectives To investigate the floating, structural, and controlled-release characteristics of a floating poly(lactic-co-glycolic acid) (PLGA)-based controlled-release drug delivery system, and determine the feasibility of this drug delivery system for intravesical instillation. Methods PLGA was dissolved in dimethylacetamide, then mixed with IR780 and doxorubicin (DOX) to prepare a drug delivery system capable of solidification and flotation on water at room temperature. Preparations of PLGA, PLGA+IR780, PLGA+DOX, and PLGA+IR780+DOX were formulated. Their floating characteristics in vivo and in vitro were investigated, along with their structural and controlled-release characteristics. Preparations of saline, DOX, and PLGA+IR780+DOX were also formulated; the content of DOX in bladder tissue delivered by each preparation was determined by fluorescence microscopy. Results PLGA exhibited stable flotation in vivo and in vitro. A honeycomb structure was observed by scanning electron microscopy. When irradiated with a near-infrared laser, IR780 generated heat that vitrified PLGA, allowing controlled release of DOX from the drug delivery system. The PLGA+IR780+DOX preparation achieved the highest content of DOX in bladder tissue. Conclusions Our floating PLGA-based controlled-release drug delivery system exhibited a honeycomb stabilized structure and achieved controlled release when irradiated by a near-infrared laser, making it an ideal drug delivery system for intravesical instillation.
Syrian Refugee Women’s Maternal Mental Health Perceptions, Coping Strategies, and Help-Seeking Practices in Lebanon
Authors: Alnaji Nada A. , Tippens Julie A. , ElRayes Wael 
Published: April 2023

Introduction: Globally, 27 million female refugees of reproductive age are subjected to numerous socio-ecological factors that increase their risks of mental health issues, especially during the postpartum period. This study seeks to explore Syrian refugee mothers’ experiences and perceptions of postpartum depression. Methods: We used a qualitative phenomenological approach to interview purposively sampled typical postpartum Syrian mothers living in informal camps in Lebanon to evaluate their maternal mental health perceptions, coping strategies, and help-seeking practices. Results: Results revealed three major themes: conceptualizing maternal depression as extraordinary and ordinary, cultural perceptions of mental health help-seeking, and coping with negative emotions. Discussions: Findings are critical to Lebanon and other Muslim refugee-hosting countries as they can inform future health policies, health care delivery models, and community interventions. Utilizing culturally and religiously appropriate frameworks in assessing and providing mental health services to this vulnerable group can substantially improve mental health services’ acceptance, utilization, and impact.
Integration of Population Health, Social Determinants, and Social Justice in Transcultural Nursing and Culturally Competent Care: White Paper by the Scholars Education Interest Group
Authors: Pacquiao Dula F. , Maxwell Joanna Basuray , Ludwig-Beymer Patti , Stievano Alessandro , Sagar Priscilla L. , Purnell Larry , Daub Katharyn F. , Halabi Jehad O. 
Published: April 2023

Introduction: As part of its mission to advance Transcultural Nursing worldwide, the Transcultural Nursing Society Scholars upholds the central role of the discipline and cultural competence in advocacy, empowerment, and transformation of the life conditions of disadvantaged populations. This White Paper affirms the Scholars’ core belief in the value of Transcultural Nursing and culturally competent care in addressing social determinants to promote health equity. Methods: The Scholars Education Interest Group proposes recommendations for changes in education, practice, and research undergirding the discipline and expand cultural competence to directly address social structural and historical forces that perpetuate health vulnerability in diverse populations. Results: Collaborative leadership between the TCNS Scholars, Board of Trustess and members should develop initiatives to foster implementation of the recommendations and promote global dissemination of exemplars in education, research and practice. Discussion: Collaborative implementation of recommendations will generate evidence of health equity outcomes through TCN and culturally competent care.
Higher Levels of Tumour-Infiltrating Lymphocytes (TILs) are Associated with a Better Prognosis, While CDK5 Plays a Different Role Between Nonmetastatic and Metastatic Colonic Carcinoma
Authors: Wang Qinghua , Yin Ruihua , Chen Xiaoxiao , Hu Bin , Jiang Bingjing , Tang Wanfen , Zhang Xia , Jin Xiayun , Ying Mingliang , Fu Jianfei 
Published: April 2023

Objective We investigated the prognostic value of cyclin-dependent kinase 5 (CDK5) in a true population-based cohort of patients with colon cancer. Methods 1. Immunohistochemical (IHC) staining was used to retrospectively analyse the expression of CDK5 in colon cancer tissue samples of 296 patients. The χ2 test, Kaplan-Meier method and Cox proportional regression model were used to analyse the difference between the patients with differential expression of CDK5 and with different stages (metastatic and nonmetastatic); 2. The number of tumour-infiltrating lymphocytes (TILs) in tumour sections was determined, and its relationship with prognosis was explored. Results 1. Among 296 patients stained for CDK5, 18 cases (6.09%) showed negative expression, 77 cases (26.01%) showed weak expression (+1), 124 cases (41.89%) showed medium positive expression (2+), and 77 cases (26.01%) showed strong positive expression (3+). The expression of CDK5 was neither related to mismatch repair nor TILs ( p > .05). In non-metastatic patients, longer progression-free survival (PFS) and cancer-specific survival (CSS) were observed in patients with high CDK5 expression (2+ or 3+) than low CDK5 expression (- or 1+), while in metastatic disease, the opposite was true ( p < .001). 2. TILs in 226 patients were detected in the study. Among them, 115 cases (50.88%) showed a low number of TILs (TILs-L), and 111 cases (49.12%) showed a high number of TILs (TILs-H). Patients with a TIL ratio greater than .2 had a significantly better CSS ( p < .001) or PFS ( p = .008) than patients with a lower TIL ratio. By multivariate analysis, TILs-H was a protective factor for CSS, however failed to reach a significant difference (hazard ratio: .59, 95% CI: .33∼1.06, p = .079), and so was the PFS (HR: .65, 95% CI: .29∼1.43, p = .279). Conclusion High expression of CDK5 indicates a good prognosis in nonmetastatic colon cancer, while it is the opposite in metastatic colon cancer, and the expression of CDK5 is unrelated to TILs. Patients with TIL-H have a better prognosis, with a proper cut-off value of 20% for colon cancer.
“Will My Baby Be OK?” A Qualitative Analysis of Pregnant Women’s Suboxone® Online Forum Posts
Authors: Moore Dorothy J. , Butzlaff Alice 
Published: April 2023

Background: Intentional or accidental drug-overdose is a leading cause of mortality in U.S. women of child-bearing age. Opioid use during pregnancy is not only associated with maternal overdose, but with low birth weight at term and neonatal abstinence syndrome (NAS). Buprenorphine was approved as a medication for opioid use disorder (MOUD) in the United States in 2002 and is for many women, a preferred treatment option versus methadone. Buprenorphine is relatively safe during pregnancy and is associated with lower rates of NAS than methadone. Given the importance of MOUD during pregnancy, relatively little information exists regarding patients’ questions and concerns about buprenorphine treatment, including the psychological challenges they face. Aims: The purpose of the study was to describe the perinatal concerns of women with opioid use disorder who posted to an online suboxone forum. Methods: Qualitative descriptive design to analyze some 170 posts from mothers with OUD to an online Suboxone® support forum over the period 2016–2021. Results: The analysis of the interview data revealed 4 important themes: (a) Stigma resulting in self-deprecation, low self-esteem, and low self-efficacy; (b) stigma from family members and loved ones; (c) stigma from the medical profession; and (d) stigma from the community at-large (social stigma). Conclusions: There is compelling evidence to emphasize the importance of open communication and support between medical personnel and patients to ensure optimal outcomes for mother and baby.
Long term outcomes of Yamane technique in various indications
Authors: Sahin Vural Gozde , Guven Yusuf Ziya , Karahan Eyyup , Zengin Mehmet Ozgur 
Published: April 2023

Introduction To describe the clinical and refractive outcomes of Yamane transconjunctival sutureless intrascleral intraocular lens (SIS IOL) fixation technique in aphakic and dislocated IOLs. Methods The aphakic and IOL dispositioned patients who underwent Yamane surgery in Bozyaka Research and Training Hospital were evaluated retrospectively. The demographic data, preoperative & postoperative best-corrected visual acuity (BCVA), spherical equivalent (SE), indication for surgery, additional surgical interventions, complications, the final status of retina, and central macular thickness (CMT) through spectral-domain optic coherence tomography (SD-OCT) were recorded. Results A total of 30 eyes of 30 patients were evaluated. The indication for surgery was aphakia in 24 patients, lens dislocation in 1 patient, and IOL dislocation in 5 patients. The mean age of participants was 64.17 ± 14.69 years, and the mean follow-up was 46.07 ± 7.96 months. The mean BCVA was improved from 0.25 ± 0.22 (−0.94 ± 0.83 log MAR) to 0.49 ± 0.24 in decimals (−0.37 ± 0.27 log MAR) (p:0.041). The mean subjective refraction improved from 10.06 ± 3.10 to −1.45 ± 0.73 D in the final visit (p < 0.05). The mean of cylindrical refraction was −1.22 ± 1.03 D in the postoperative period. At the time surgery, 36.6% of patients required at least one additional surgical procedure. During follow-up period, two (6.7%) out of 30 of patients had retinal detachment, two of the patients (6.7%) occured epiretinal membrane, one of the patients (3.3%) had cystoid macular edema. Conclusion Yamane SIS IOL fixation technique is an effective and reliable surgical option in complicated cases that require additional surgical interventions in long-term follow-up.