bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive Clinical, Neuropsychological, and Metabolic Impact of Liver Transplantation in Patients With Argininosuccinate Lyase Deficiency
Authors: Siri Barbara , Greco Benedetta , Martinelli Diego , Cairoli Sara , Guarnera Alessia , Longo Daniela , Napolitano Antonio , Parrillo Chiara , Ravà Lucilla , Simeoli Raffaele , Spagnoletti Gionata , Taurisano Roberta , Veraldi Silvio , Pietrobattista Andrea , Spada Marco , Dionisi‐Vici Carlo 
Published: January 2025

ABSTRACTLiver transplantation (LTx) is increasingly used in Urea Cycle Defects (UCDs) to prevent recurrent hyperammonemia and related neurological irreversible injury. Among UCDs, argininosuccinate lyase deficiency (ASLD) has a more complex phenotype than other UCDs, with long‐term neurocognitive deficits. Therefore, the role of LTx in ASLD is still debated. The impact of LTx on nine patients with early‐onset ASLD was assessed through pre‐ and post‐LTx clinical, neuropsychological, MRI and biochemical evaluations. After LTx, no episodes of metabolic decompensations were reported. Neuropsychological evaluations documented significant improvement in cognitive/developmental functioning especially in patients transplanted in early childhood. Improvements were also highlighted in daily living skills and emotional‐behavioral problems, with a reduction in attention disturbances and somatic complaints. Movement disorders resolved after LTx in patient transplanted in early childhood. Any patients developed epilepsy with stability of EEG alterations after LTx. A positive effect of LTx on other disease‐related outcomes such as growth, diet, medications, hospitalizations, and long‐term ASLD‐related complications was highlighted. The primary biomarker argininosuccinic acid dramatically reduced in plasma after transplantation with a decreasing trend in CSF at long‐term follow‐up. Moreover, health‐related quality of life improved after LTx, especially when assessed through MetabQoL, a tool designed for intoxication diseases such as ASLD. In conclusion, our study showed a global beneficial impact of LTx in early‐onset ASLD patients to avoid episodes of hyperammonemia, and improve neurocognitive outcome, adaptive and behavioral deficits when performed in early childhood with a dramatic benefit in terms of quality of life.
Electronically Preresonant Coherent Anti‐Stokes Raman Scattering Microscopy
Authors: Burde Rushikesh , Reuter Nico , Pruccoli Andrea , Birech Zephania , Winterhalder Martin , Zumbusch Andreas 
Published: January 2025

ABSTRACTCoherent anti‐Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS) microscopy are key techniques for label‐free vibrational imaging. However, their application is often limited by poor sensitivities. Recent advancements have shown that similar to spontaneous resonance Raman spectroscopy, SRS microscopy sensitivity can be greatly enhanced under electronic preresonance conditions. While electronic enhancement of CARS signals in spectroscopy was reported in the 1970s, its application in microscopy remains less explored. This study presents experimental results demonstrating significant sensitivity enhancements in CARS microscopy by choosing excitation wavelengths near electronic transitions in sample molecules, achieving detection levels down to low micromolar concentrations. We also conducted both experimental and theoretical investigations on spectra with and without electronic resonances, addressing the background signals encountered when using this method. Our findings advance the understanding of electronic preresonance effects in CARS and offer practical sensitivity enhancements, broadening the scope for coherent Raman imaging at lower concentrations.
FKBP Prolyl Isomerase 11: A Novel Oncogene Interacting With SRSF1 in Esophageal Squamous Cell Carcinoma
Authors: Ding Zheng , Hou Zhichao , Zhang Tangjuan , Wang Peng , Pan Xue , Li Xiangnan , Zhao Song 
Published: January 2025

ABSTRACTEsophageal squamous cell carcinoma (ESCC) is one of the main subtypes of esophageal carcinoma with high morbidity. This study aimed to explore the role of FKBP prolyl isomerase 11 (FKBP11) in ESCC and investigate the underlying mechanism. FKBP11 levels in ESCC tumor tissues and cell lines were measured. Cell function assays were conducted to evaluate the role of FKBP11 in ESCC cells. The xenograft mouse model was established to validate the effect of FKBP11 on ESCC tumorigenesis in vivo. The co‐immunoprecipitation assay was performed to determine the FKBP11‐interacting proteins. Obvious upregulations in FKBP11 expression were found in ESCC tumor tissues and cell lines. In vitro, FKBP11 knockdown weakened cell proliferation, migration, and invasion capacities and reinforced cell apoptosis in ESCC cells. In vivo, FKBP11 knockdown slowed ESCC tumorigenesis. The following mechanism investigation determined serine and arginine‐rich splicing factor 1 (SRSF1) as the FKBP11‐interacting protein in ESCC cells. FKBP11 directly bound to SRSF1 and FKBP11 knockdown decreased SRSF1 mRNA level. SRSF1 overexpression abrogated the inhibitory effect of FKBP11 knockdown on the proliferation and migration of ESCC cells. KBP11 functions as an oncogene in ESCC by targeting SRSF1.
Neurophysiological Insights into the Pathophysiology of Stiff‐Person Spectrum Disorders
Authors: Moura João , Rocchi Lorenzo , Zandi Michael , Balint Bettina , Bhatia Kailash P. , Latorre Anna 
Published: January 2025

AbstractBackgroundStiff Person Spectrum Disorders (SPSD) are classically defined by the presence of muscle stiffness, spasms and hyperactivity of the central nervous system. There is a notable correlation between neurophysiological features and the clinical hallmark of SPSD, which has greatly encouraged the use of these techniques for diagnostic purposes. Besides, electrophysiological techniques allow for a functional evaluation of the ‘hyperactivity of the CNS’, thus offering the opportunity to clarify the mechanisms underlying this disorder. This review delves into the current knowledge on the electrophysiological aspects of SPSD, highlighting the pivotal role of various studies in unravelling its pathophysiology.MethodsLiterature review for studies on SPSD that included a neurophysiological evaluation.ResultsWe first examined the abnormal neurophysiological findings of SPSD across the central nervous system, from the spinal circuit to the motor cortex. Subsequently, we discussed their pathological implications and explored how these findings can be interpreted within the framework of an immune‐mediated disorder.ConclusionsTwo primary questions remain unanswered: the localization of the primary abnormality within the central nervous system and the connection between the autoimmune basis of SPSD and its neurophysiological aspects. Addressing these questions could provide invaluable insights into SPSD etiology and targeted therapeutic strategies.
Unveiling meteorological synergies in the coupling of an abnormal easterly wave and cutoff low in South Africa's February 2023 rainfall
Authors: Fazel‐Rastgar Farahnaz , Sivakumar Venkataraman , Rostami Masoud , Fallah Bijan 
Published: January 2025

AbstractThis study seeks to understand the meteorological mechanisms that caused widespread and heavy rainfall from 6 to 14 February 2023, over southern Mozambique and the eastern and northeastern areas in South Africa, including Limpopo Province, Mpumalanga Province and northern KwaZulu‐Natal, by examining different outputs from reanalysis datasets. The heavy rainfall had a substantial hydrological impact, leading to significant flooding and disruptions. This research revealed that a slow‐moving cutoff low (COL) system remained over the central parts of South Africa, triggering extensive and heavy rainfall mostly over the northeastern and eastern provinces. The outcomes from the reanalysis datasets display the influence of the weather system and the interaction between an initiated westerly wave, which converted into a near‐stationary upper‐air cold core upper air COL system, and the easterly wind wave associated with the South Indian Ocean Convergence Zone (SICZ), bringing significant warm humid air from the Indian Ocean into the study area. This study revealed an abnormal structural pattern in the wind vectors, low‐pressure trough, upper and mid‐tropospheric westerly flows and humidity compared with the long‐term climate normal values over Mozambique and the northeastern and eastern regions of southern Africa. This event is exciting from a meteorological perspective due to its intensity and duration, the involvement of cyclonic activity and its implications for understanding the impacts of climate change on weather patterns in southern Africa. The heavy rainfall had a substantial hydrological impact, leading to significant flooding and disruptions, providing valuable data for improving forecasting models and disaster preparedness strategies and underscoring the importance of enhancing climate resilience in regions prone to extreme weather.
Role of infant and early‐childhood nutrition on gut inflammation, stunting, growth, and development in the African context: A narrative review
Authors: Ebrahim Mohamedraza , Manji Karim 
Published: January 2025

AbstractThis article synthesizes the existing research evidence from Tanzania, a low‐ to middle‐income country, highlighting the persistent issue of growth stunting. Stunting begins early in life, potentially even in utero. It is becoming increasingly clear that infant and childhood environmental enteric dysfunction plays a significant role in perpetuating the observed stunting. The repercussions of this condition include poor growth and detrimental effects on neurodevelopment, preventing affected children from reaching their full potential. The economic implications of this are substantial. The manuscript outlines the trajectory from low birth weight and suboptimal lactation to altered weaning practices and changes in the gut microbiome. It also presents current perspectives on how to mitigate these adverse effects, with a focus on early interventions in lactation and feeding during the crucial first 1000 days of life.
Cremated Bone in Archaeology: Ethical Considerations in the Excavation, Analysis, Storage, and Display of Cremated Bone in the United Kingdom
Authors: Squires Kirsty , McKinley Jacqueline , Roberts Charlotte A. , Biers Trish 
Published: January 2025

ABSTRACTIn the United Kingdom, the study of archaeological cremated human remains has risen exponentially over the past three decades. Consequently, we are gaining a more rounded understanding of past communities, rather than a skewed perspective caused by an overreliance on studies of human remains from inhumation graves. Yet, ethical considerations related to the excavation, recording, analysis, storage, and display of cremated remains are not explicitly explored in the literature. This paper redresses this imbalance and explores the key ethical challenges based on the authors' professional experiences in commercial archaeology, universities, and museums. Recommendations for best ethical practice are provided and are aimed at all relevant parties who may encounter cremated bone in their place of work. Clearly, best practice can only be achieved by ensuring practitioners (including students) have appropriate ethics training, including consulting with specialists where experience of cremated human bone may be lacking within a team. The attainment of standardized ethical protocols explicitly addressing cremated remains and implementing training initiatives should be spearheaded by professional bodies. Ultimately, we hope this paper will encourage the inclusion of cremated remains in ethical discourses within archaeology, osteoarchaeology, and museology.
Diagnosing Acute Graft‐Versus‐Host Disease in Children Undergoing Hematopoietic Stem Cell Transplantation—Comparison of the Modified Glucksberg Criteria Versus the MAGIC Criteria
Authors: Weischendorff Sarah , Kamari‐Kany Nakisa , Kielsen Katrine , Ifversen Marianne , Müller Klaus 
Published: January 2025

ABSTRACTDiagnosing acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) is challenging due to heterogeneity in interpreting current clinical criteria. Recently, the Mount Sinai Acute GvHD International Consortium (MAGIC) criteria were introduced to improve diagnostic consistency. In a study of 117 pediatric patients undergoing HSCT, the modified Glucksberg and the MAGIC criteria were retrospectively compared. The MAGIC criteria identified significantly more cases of gastrointestinal (GI) aGvHD and increased overall severity, important for guiding systemic treatment. Diagnosing upper GI aGvHD based solely on symptomatology (MAGIC) proved difficult, suggesting a need for stricter definitions. For lower GI aGvHD, the modifications were clearly beneficial, although diarrhea duration remains unspecified.
Evaluation of the effect of triphenyl phosphate on hemp fiber‐reinforced polycarbonate composites for 3D printing applications
Authors: Ceylan Engin Irem , Cakici Alp Nese , Aytac Ayse 
Published: January 2025

AbstractThis study examined the effects of adding plasticizer to 3D printable hemp fiber‐reinforced polycarbonate (PCH) composites to improve composite properties and facilitate the 3D printing process. The plasticizer or flame retardant, triphenyl phosphate (TPP), was added to the PCH composite at three different ratios (5%, 10%, and 20%). The characterization of composites was realized with Fourier‐transformed infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), thermogravimetric analysis (TGA), rheological analysis, tensile testing, limiting oxygen index (LOI), and scanning electron microscope (SEM) analyses. According to DSC results, while the glass transition temperature of pure PC was 148.44°C, it was reduced to 93.74°C with the addition of TPP. TGA analysis showed that PC has the best thermal resistance. The tensile test demonstrated that 20%TPP‐containing samples exhibited a value of 59.52 MPa, representing a 38% increase compared to pure PC. Additionally, the LOI value of this sample is 32.4, increased by 12% compared to pure PC. Furthermore, SEM analysis showed that TPP reduced the gaps between the matrix and fiber. In general, the properties improved with an increase in TPP content. A composite was developed from a partially natural and more sustainable material, with improved properties and 3D printing processability compared to pure polycarbonate.Highlights
10%TPP‐added composite has demonstrated the best thermal resistance
20% TPP‐added composite has 32.4 LOI and 59.52 MPa tensile strength values
Adding hemp fiber to PC did not significantly change the Tg value
20% TPP addition to the composite reduced the Tg value by 63%.
The 3D printing process has become easier with the increasing TPP ratio.
Debonding and collapse simulation of plastic liners for type IV hydrogen storage vessels
Authors: Zha Yan , Jiao Xiangdong , Dang Kaifang , Liu Yuwei , Duan Yuchen , Liu Gonghan , Yang Weimin , Xie Pengcheng 
Published: January 2025

AbstractType IV hydrogen storage vessels, equipped with lightweight, thin plastic liners provide a cost‐effective solution to enhance the storage density of large‐capacity road transport tanks. However, during rapid depressurization, the plastic liner may collapse and debond from the CFRP, compromising the structural integrity and load‐bearing capability of the vessel. To address this critical issue, this study develops an innovative finite element simulation framework that dynamically models the collapse behavior of the liner and interfacial debonding under rapid decompression. The model reveals the sequential progression of liner collapse, which involves initial buckling deformation, CFRP debonding, wrinkling, and eventual partial collapse, leading to structural failure. A comprehensive parametric study was conducted to assess the sensitivity of collapse pressure to various influencing factors. The results indicate that the onset of liner collapse is highly sensitive to initial geometric imperfections. Furthermore, for large‐capacity Type IV hydrogen storage vessels, a liner thickness‐to‐diameter ratio of (w/D = 0.01) significantly improves the liner's resistance to collapse. These findings provide valuable insights into optimizing the design of hydrogen storage vessels to enhance safety and performance.Highlights
Dynamic process of buckling‐debonding‐collapse failure of plastic liner.
The collapse failure of plastic liner is highly sensitive to initial defects.
Thickness to diameter ratio of 0.01 boosts collapse resistance of plastic liner.
Safety Assessment of Influenza Vaccination for Neurological Outcomes Among Older Adults in Japan: A Self‐Controlled Case Series Study
Authors: Ogawa Mitsunori , Takeuchi Yoshinori , Iida Yukino , Iwagami Masao , Uemura Kohei , Ono Sachiko , Michihata Nobuaki , Koide Daisuke , Matsuyama Yutaka , Yasunaga Hideo 
Published: January 2025

ABSTRACTPurposeTo assess adverse neurological risks following influenza vaccination in older adults.MethodsUsing a linked database of healthcare administrative claims data and vaccination records from an urban city in Japan (April 1, 2014, to March 31, 2020), we conducted an observational study utilizing a self‐controlled case series design. We identified individuals aged ≥ 65 years who experienced adverse neurological outcomes, defined as hospitalizations related to epilepsy, paralysis, facial paralysis, neuralgia, neuritis, optic neuritis, migraine, extrapyramidal disorders, Guillain–Barre syndrome, or narcolepsy. We used conditional Poisson regression to analyze within‐subject incidence rate ratios, comparing the risk of these outcomes during risk periods following influenza vaccination (0–6 days and 7–29 days after each vaccination) with nonvaccination periods. Our analysis was adjusted for age and season groups as time‐varying covariates.ResultsWe enrolled 3283 eligible individuals (men: 1643; mean [standard deviation] age: 76 [7.3] years). The incidence rate ratio for the outcome during the risk periods was 0.93 (95% confidence interval, 0.66–1.30) in risk period 1 (0–6 days after vaccination) and 1.14 (0.96–1.35) in risk period 2 (7–29 days after vaccination), respectively.ConclusionsWe found no evidence that the risk of adverse neurological events was increased after influenza vaccination in older adults. These results may help reassure older adults who are hesitant to receive influenza vaccination because of concerns regarding adverse neurological outcomes.
The European Drug–Drug Interaction (EuroDDI) Study Protocol: A Cross‐Country Comparison of Drug–Drug Interaction Prevalence in the Older Community‐Dwelling Population
Authors: Hughes John E. , Menditto Enrica , Mucherino Sara , Orlando Valentina , Moreno‐Juste Aida , Gimeno‐Miguel Antonio , Poblador‐Plou Beatriz , Aza‐Pascual‐Salcedo Mercedes , González‐Rubio Francisca , Ioakeim‐Skoufa Ignatios , Bennett Kathleen , Cahir Caitriona 
Published: January 2025

ABSTRACTBackgroundDrug–drug interactions (DDIs), highly prevalent amongst the elderly, can lead to avoidable medication‐related harm. Cardiovascular and central nervous system (CNS) drugs are commonly implicated. To date, there is no consensus on how to measure DDIs, making comparisons across countries challenging.ObjectiveTo (i) establish a common data model (CDM) to measure DDI prevalence in the older (aged ≥ 70 years) community‐dwelling population of three European countries and (ii) compare and describe cardiovascular and CNS DDI prevalence rates across these countries.MethodsThis cross‐country study will apply a harmonised method of DDI identification and analysis using the WHO ATC classification system and national pharmacy claims data from three European countries (Ireland, Italy, Spain). Patients aged ≥ 70 years dispensed ≥ 2 medications during 2016 will be identified from each country's national database. ‘Severe’ cardiovascular and CNS DDIs (i.e., may result in a life‐threatening event/permanent detrimental effect) will be identified using the British National Formulary and Stockley's Drug Interactions. Two separate lists of ‘severe’ DDIs, per medications reimbursed, will be applied to each database: (i) DDIs relevant to each individual country and (ii) DDIs relevant to all three countries. DDIs will be defined as co‐dispensed (same day) and concomitantly (±7 days) dispensed.ResultsDescriptive statistics, including DDI prevalence and 95% confidence intervals, will be reported for each country. Prevalence will be pooled and compared across countries using random effects models and meta‐regression, where feasible.ConclusionThe EuroDDI study will develop a harmonised method to measure and compare DDI prevalence across health‐related databases in Europe.
Improved infrared stealth and electromagnetic interference shielding performance of polyimide‐derived carbon aerogels by constructing heterogeneous nanopores
Authors: Shen Lu , Jiang Xinyue , Ni Long , Luo Yinfu , Liang Mei , Yang Yunhua , Zhou Shengtai , Zou Huawei 
Published: January 2025

AbstractWith the rapid development of science and technology, there is an increasing demand for lightweight materials with excellent electromagnetic interference (EMI) shielding and infrared stealth performance for space applications. In this study, a series of polyimide/silica (PI/SiO2) aerogels were fabricated by blending, which were dried using supercritical CO2 drying method. Then, PI/SiO2 composite aerogels were carbonized to prepare carbon aerogels with superior thermal insulation and EMI shielding properties. The carbonized PI/SiO2 aerogels contained mesopores which enhanced the interfacial thermal resistance and improved the thermal insulation performance by 69% when compared with those samples without SiO2. The presence of mesopores adjusted the impedance matching of carbon aerogels, which allowed more EM waves to enter inside of the aerogels and dissipate through multiple reflections, thereby achieving absorption‐dominant EMI shielding performance. This study proposed a viable approach to preparing PI‐based carbon aerogels with excellent infrared stealth and EMI shielding performance, which show promising applications in aerospace and related industries.Highlights
The introduction of SiO2 regulated the microstructure of carbon aerogels.
The thermal conductivity of carbon aerogels reached as low as 0.10 W/mK with 3 wt% SiO2.
The EMI performance of carbon aerogel was enhanced from 22.4 to 33.5 dB.