bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality by Design Enabled Systematic Optimization of Calcineurin Inhibitor
loaded Polymeric Nanoparticles for Sustained Topical Delivery in Psoriasis
Authors: Ahlawat Priyanka , Patel Shruti , Dharmasi Abhay , Patel Asha 
Published: January 2023

Background:
The present work describes the systematic development and optimization of
cyclosporine-A loaded biodegradable polymeric nanoparticulate system using quality by design paradigm,
to achieve an effective and sustained release of the cyclosporine-A to the targeted lesion of
plaque psoriasis.

Methods:
The polymeric nanoparticles were formulated using the solvent emulsification method using
Polycaprolactone and Hyaluronic acid as polymers. An Ishikawa fishbone diagram was constructed
for risk assessment and to describe various plausible product and process variables influencing the
quality target product profile. Critical process and product parameters were further optimized by Response
surface methodology using Central Composite Design by Minitab 19 Software. The development
and optimization of cyclosporine-A loaded biodegradable polymeric nanoparticles were further
carried out by developing the relationship of independent variables viz. amount of polymers polycaprolactone
and hyaluronic acid on dependent variables viz. particle size, zeta potential, and entrapment
efficiency and exploring their interactions. Validation of the model was done by checkpoint
analysis method.

Results:
The particle size, zeta potential, and Entrapment efficiency of the optimized polymeric nanoparticles
were found to be 317.2 ± 1.271, -0.249 ± 0.903 mV and 83.33 ± 1.124%, respectively. SEM
images of the lyophilized nanoparticles showed spherical particles. In-vitro drug release study showed
a slow and sustained release of 88.52 ± 1.10% of drugs up to 14 days.

Conclusion:
The nanoparticulate system would also help in overcoming the problem associated with
poor water solubility and low permeability of the drug and will explore drug loaded biodegradable
polymeric nanoparticles as a novel platform for effective therapy of psoriasis.
Study on Thermal Decomposition Mechanisms of Indian Honey of
Different Origins using Differential Scanning Calorimetry and
Vector Elemental Analyzer Techniques
Authors: Sajid Mohamad Abdul , Marojus Sateesh , Basha Hakeem Aleem , Chaudhary Anil Kumar , Jaleeli Kaleem Ahmad 
Published: January 2023

Background:
This paper reports the thermal decomposition mechanisms of
five pure honey samples of Indian origin using Differential Scanning Calorimetry (DSC)
and Euro Vector Elemental Analyzer (EVEA) techniques.

Methods:
We have identified three transition temperatures along with a change in specific
heat capacity (ΔCp), change in enthalpy (ΔH), and Gibbs free energy (ΔG) of these
samples. Finally, samples were subjected to thermal elemental analyses to quantify the
released amount of O, N, C, and H. Since glucose, fructose, and sucrose are the principal
ingredients, they are present in the honey sample, along with good numbers of other
organic molecules in small quantities. In addition, we have also recorded the C, H, and
O percentages of pure glucose, fructose, and sucrose powders and correlated the ratio of
C/H and C/O with honey samples.

Results:
The decomposition temperature for honey samples lies between 113.83°C and
127.07°C range. The ratios of these elements help us to ascertain the purity of these
samples as well as to identify the dominating percentage of principal ingredients present
in the given honey sample.

Conclusion:
The obtained experimental results were further used to identify the source
of origin and medicinal quality and stability of honey samples.
Microwave Assisted Aza-michael Additions Towards β-amino Acids
Authors: Yinqi Fan , Magdalini Matziari 
Published: January 2023

Background:
β-amino acids are non-natural amino acids, where the amino group is
attached to the β-carbon instead of the α-carbon. Peptides containing β-amino acids present with
particular secondary structures and remarkable chemical and biological properties. β-peptides are
used as peptidomimetics, based on the resistance to hydrolysis in vivo, with various important applications
in the field of Medicine.

Methods:
Several synthetic methods have appeared in recent years, with the Aza- Michael conjugate
addition reactions, being a very effective approach towards β-amino acids. Microwave irradiation
mediated reactions have also attracted much interest since they significantly improve the
reaction yields while reducing the reaction time and avoiding by-products formation. The aim of
this project has been the development of a reliable and general synthetic methodology towards β2
and β3 amino acids with the use of conjugate additions of N-nucleophiles to substituted acrylate
derivatives. The application of effective catalysts has been also examined here.

Results:
The results show that the acrylate precursors of β2 and β3 amino acids with side chains
corresponding to Phe, Asp, Ile, Leu, Val, and Tyr have been synthesized successfully by using a
one-pot Horner-Wadsworth-Emmons reaction, and they have been used for the addition of Nnucleophiles,
with a study on conditions and yields optimization.

Conclusion:
With the main challenge for β-amino acid synthesis being that there is still no general
method to synthesize different types of β-amino acids corresponding to all-natural α-amino
acids, the proposed synthetic methodology may offer this possibility.
Antimicrobial Therapeutic Strategies for Enterococcus faecalis In Dental
Infections - Past, Present and Future
Authors: Lokitha R.  , Nandakumar Namitha , Harish K.  , Arulmozhi P.  , Jayakumar Aarthi , Anbarasi K.  , Paul C. Benedict 
Published: January 2023

Abstract:
Enterococcus faecalis is a common opportunistic pathogen that can infect various
tissues in the human body and in particular, the oral cavity. It has been implicated in periodontal
disease, oral mucosal lesions in immunocompromised patients, peri-implantitis, peri-radicular
abscesses, and root canal infections. They are also most prevalent in secondary endodontic
infections and are recognized as treatment-resistant bacteria in the root canal. Virulence factors
help in this pathogenicity as some factors aid its adherence to the surface. It has become a
research focus in recent times for its resistance to various antibiotics like vancomycin and so,
the search for alternative therapeutic approaches has also evolved. Although various chemical
irrigants such as sodium hypochlorite (NaOCl), chlorhexidine (CHX), iodine potassium iodide
(IKI), calcium hydroxide (Ca(OH)2) and chlorine dioxide (ClO2) have been used for years, the
use of plant extracts and essential oils have attracted the researchers to explore their activity
against various dental pathogens like E. faecalis. Recently, it has been found that the phages
are more effective in treating biofilm than antibiotics and it has also been observed that they
are effective when used in combination with antibiotics. In this review, we have presented
various treatment strategies that have been in use for treating dental infections and also discussed
future therapeutic approaches, which, may help unfold promising novel strategies.
Error Prediction Method of Electronic Voltage Transformer based on Improved
Prophet Algorithm
Authors: Li Zhenhua , Zhong Yue , Abu-Siada Ahmed , Li Qiu 
Published: January 2023

Background:
Electronic voltage transformer (EVT) is an essential metering device for
future substation automation systems. One of the main drawbacks of EVT is its poor long-term
stability, which affects its measurement accuracy. This will, in turn, adversely affect the entire
protection and control systems it is employed for.

Objective:
Aiming at reducing the EVT measurement error over long-term operation, an EVT error
prediction method combining Prophet, temporal convolutional network (TCN) and selfattention
is proposed in this paper.

Methods:
The proposed method is based on building prophet and TCN error prediction models to
estimate preliminary prediction values. On this basis, self-attention is introduced to further extract
features and make full use of the useful information in historical data. Then the secondary prediction
can be achieved, and the final predicted value can be reported as an output.

Results:
The proposed method is validated by applying the error data of an EVT in a substation to
its historical operation. The results show that the model can effectively predict the error trend of
EVT.

Conclusion:
The prediction results of this method are similar to the fluctuations of the actual values,
indicating that it provides a new reliable method for error prediction of EVT.
A Narrative Systematic Review of the Effectiveness of Repetitive
Transcranial Magnetic Stimulation (rTMS) in the Treatment and
Management of Borderline Personality Disorder
Authors: Kafas Georgios , Umla-Runge Katja 
Published: January 2023

Background:
Borderline Personality Disorder (BPD) is a psychiatric condition that
affects approximately 2% of the population worldwide. It can present many challenges and can
therefore be difficult to treat successfully by mental health professionals.

Aim:
The aim of this systematic review was to detect whether repetitive Transcranial Magnetic
Stimulation (rTMS) is an effective intervention for the management of BPD to the point where
there would be a reduction of the BPD symptoms and challenging behaviour.

Methods:
A literature search was conducted systematically using the following databases:
PROSPERO, PUBMED, GOOGLE SCHOLAR, WEB OF SCIENCE, COCHRANE
LIBRARY, SCOPUS, EMBASE and CLINICALTRIALS.GOV. Included studies were primary
research studies of adult patients with a diagnosis of BPD who received rTMS treatment.

Results:
Nine studies were identified which ranged from a case report to a randomised controlled
trial (RCT). While rTMS improved certain symptoms of BPD patients, such as affective
instability, impulsivity and outbursts of anger; overall, some results lacked statistical significance
and, due to the lack of robust evidence, it is uncertain if rTMS is an effective intervention
for BPD.

Conclusions:
rTMS treatment showed some promising results in reducing the severity of
symptoms for a number of patients. Studies varied with regard to the location of the target
stimulation site, including different prefrontal brain regions and the cerebellum, as well as other
rTMS protocol characteristics. These methodological differences in the application of the
intervention and their impact on BPD symptomatology need to be explored more systematically
in future research. Higher quality studies with larger sample sizes are needed in order to assess
further the effectiveness of rTMS interventions on BPD symptoms.
The Impacts of Computer-Aided Detection of Colorectal Polyps on Subsequent Colonoscopy Surveillance Intervals: Simulation Study
Authors: Lui Ka Luen Thomas , Liu Sze Hang Kevin , Leung Kathy , Wu Joseph T , Zauber Ann G , Leung Wai Keung 
Published: January 2023

Background
Computer-aided detection (CADe) of colorectal polyps has been shown to increase adenoma detection rates, which would potentially shorten subsequent surveillance intervals.

Objective
The purpose of this study is to simulate the potential changes in subsequent colonoscopy surveillance intervals after the application of CADe in a large cohort of patients.

Methods
We simulated the projected increase in polyp and adenoma detection by universal CADe application in our patients who had undergone colonoscopy with complete endoscopic and histological findings between 2016 and 2020. The simulation was based on bootstrapping the published performance of CADe. The corresponding changes in surveillance intervals for each patient, as recommended by the US Multi-Society Task Force on Colorectal Cancer (USMSTF) or the European Society of Gastrointestinal Endoscopy (ESGE), were determined after the CADe was determined.

Results
A total of 3735 patients who had undergone colonoscopy were included. Based on the simulated CADe effect, the application of CADe would result in 19.1% (n=714) and 1.9% (n=71) of patients having shorter surveillance intervals, according to the USMSTF and ESGE guidelines, respectively. In particular, all (or 2.7% (n=101) of the total) patients who were originally scheduled to have 3-5 years of surveillance would have their surveillance intervals shortened to 3 years, following the USMSTF guidelines. The changes in this group of patients were largely attributed to an increase in the number of adenomas (n=75, 74%) rather than serrated lesions being detected.

Conclusions
Widespread adoption of CADe would inevitably increase the demand for surveillance colonoscopies with the shortening of original surveillance intervals, particularly following the current USMSTF guideline.
A Gamified Real-time Video Observed Therapies (GRVOTS) Mobile App via the Modified Nominal Group Technique: Development and Validation Study
Authors: Abas Siti Aishah , Ismail Nurhuda , Zakaria Yuslina , Ismail Ismassabah , Mat Zain Nurul Hidayah , Yasin Siti Munira , Ibrahim Khalid , Razali Asmah , Mohd Yusoff Mas Ahmad Sherzkawee , Ahmad Norliza , Chinnayah Thilaka 
Published: January 2023

BackgroundThe success rate of tuberculosis (TB) treatment in Malaysia remains below the recommended World Health Organization target of 90% despite the implementation of directly observed therapy, short-course, a physical drug monitoring system, since 1994. With increasing numbers of patients with TB in Malaysia defaulting on treatment, exploring another method to improve TB treatment adherence is vital. The use of gamification and real-time elements via video-observed therapies in mobile apps is one such method expected to induce motivation toward TB treatment adherence.ObjectiveThis study aimed to document the process of designing, developing, and validating the gamification, motivation, and real-time elements in the Gamified Real-time Video Observed Therapies (GRVOTS) mobile app.MethodsThe modified nominal group technique via a panel of 11 experts was used to validate the presence of the gamification and motivation elements inside the app, which were assessed based on the percentage of agreement among the experts.ResultsThe GRVOTS mobile app, which can be used by patients, supervisors, and administrators, was successfully developed. For validation purposes, the gamification and motivation features of the app were validated as they achieved a total mean percentage of agreement of 97.95% (SD 2.51%), which was significantly higher than the minimum agreement score of 70% (P<.001). Further, each component of gamification, motivation, and technology was also rated at 70% or more. Among the gamification elements, fun received the lowest scores, possibly because the nature of serious games does not prioritize the fun element and because the perception of fun varies by personality. The least popular element in motivation was relatedness, as stigma and discrimination hinder interaction features, such as leaderboards and chats, in the mobile app.ConclusionsIt has been validated that the GRVOTS mobile app contains gamification and motivation elements, which are intended to encourage medication adherence to TB treatment.
Heat management of thermally coupled reactors for conducting simultaneous endothermic and exothermic reactions
Authors: Chen Junjie 
Published: January 2023

Computational fluid dynamics simulations are carried out to better
understand how to manage thermally coupled reactors for conducting
simultaneous endothermic and exothermic reactions. Particular emphasis
is placed upon the mechanisms involved in the heat transfer processes in
thermally coupled reactors for hydrogen production by steam reforming.
The effects of catalyst layer thickness on the enthalpy of reaction,
methanol conversion, and hydrogen yield are delineated. The oxidation
and reforming reaction rates involved in the endothermic and exothermic
processes are determined. Contour maps denoting temperature, enthalpy,
and species mole fractions are constructed and design recommendations
are made. The results indicate that the waste heat can efficiently be
recovered in a low-temperature region, although the reactivity of a
steam reforming reaction is low in such a region. The steam reforming
device is configured as to be heated by part of the combustion heat to
cause a steam reforming reaction in the device. The steam reforming
reaction is endothermic and is therefore typically carried out in an
externally heated steam reforming reactor. The incorporation of a
simultaneous exothermic reaction to provide an improved heat source can
provide a typical heat flux of roughly an order of magnitude above the
convective heat flux. Structured catalysts offer heat transfer benefits
and extra activity, which is more effective in the inlet zone of the
steam reformer. The metallic support is formed substantially to have the
same shape as the reactor wall and is arranged in a direct heat
conduction relationship with the reactor wall. Desirably all of the
tubes contain the same proportions of structured catalyst and
particulate catalyst, which provides the benefits of the higher
activity, higher heat transfer, and low pressure drop of the structured
catalyst at the inlet end and the benefit of the stronger particulate
catalyst at the outlet end. Heat transport is more efficient when
catalyzed hardware is used in the steam reforming process.
Keywords: Heat transfer; Heat management; Heat fluxes; Heat
losses; Heat resistances; Heat exchange
Raiz espiritual da Teologia da Libertação
Authors: Leite Pedro Igor 
Published: January 2023

O presente artigo se propõe revisitar parte da obra de Gustavo Gutiérrez com o intuito de investigar, do ponto de vista epistemológico, o método próprio de sua teologia. Nesta empreitada, partimos da espiritualidade como raiz da grande Teologia da Libertação. É, de fato, na experiência místico-contemplativa, interpretada posteriormente como práxis cristã que acontecerá a intuição para uma metodologia estruturada em dois momentos intercruzados: de um lado, a práxis como ato primeiro, lugar da experiência, do silêncio, da compaixão e solidariedade; de outro, como ato segundo, a reflexão crítica, científica, elaborada à luz do silêncio primeiro. Todo este projeto para não cair em esterilidade teórica ou utópica precisa ser interpretado através da perspectiva do pobre, de duas formas: através da imersão em seu mundo próprio e com o auxílio das ciências sociais, mesmo que para isto seja necessário o aporte da análise marxista, lida de modo crítico e atento às incompatibilidades teóricas com a fé cristã. Este caminho metodológico-espiritual orienta a Igreja a fazer uma opção preferencial pelos pobres, a fim de uma libertação integral, capaz de dar autêntico testemunho da ressurreição.

Palavras-chave: metodologia; pobre; libertação; espiritualidade; Gutiérrez.
Digital Communication & Socialization Using Media Video Content During Pandemic
Authors: Valentina Anny , Chrissandy Ruby , Jesslyn Brigitta , Setyanto Yugih 
Published: January 2023

A continuation research about the media used by human to communicate during PSBB period. This content of this research is about type of creative contents that can be used on social media. From the previous research, it was found that, in order to survive during pandemic and to live their daily lives, human need socializing and entertainment. Those are two important things for them. The purpose of this research is to find out types of media and digital content that are not only interesting to the respondent but also effective in conveying the communication message and can be utilize as a socialization platform. The concept of "social-media forum" which is applied to the published contents is considered different from other content in general. When the speaker invited is a person who also experiencing the same problem, audience interprets them as a friend who understand the problem and their feelings deeply, and from this angle it is hoped that the speaker and the audience can start to bond to exchange stories and opinions, not particularly about the solutions but might be just a perspective from different angle. However, doing this in virtually because of pandemic is tiring, all parties involved felt extreme fatigue after the event was over. It is because virtual meetings force human brain and body to put more focus and more alert for a long time, in the end, even casual conversation feels tiring. The samples taken for this research are located in Jakarta, focused to 20-29 years old men and women. Data collection method is using qualitative approach with observation techniques, literature study, FGD, and interviews. When situations force us to shift into the digital and virtual realms, a recommendation for creative content format for screen-based social media is needed to be studied further, resulting in all parties involved do not have to feel an extreme fatigue but can become a useful communicator who offers solutions to others.
<p>relationship of deprivation and gender to perception of barriers, optimism and attachment during the postsecondary transition</p>
Authors: Douglas Walter , Topping Keith 
Published: January 2023

Introduction. High school students’ self-reports about their perception of barriers, optimism and attachments in relation to the postsecondary transition were examined.Method. Factor analysis of an inventory administered to 1044 high school students (573 males and 471 females) who attended six urban schools identified three factors.Results. ANOVA indicated that students living in areas of higher deprivation reported perception of more career barriers and fewer career scaffolding attachments. Males were more optimistic about their career prospects but reported fewer career scaffolding attachments. There was an interaction between deprivation and gender with regard to career optimism.Discussion and Conclusion. These results contribute to an explanation of why failure to obtain a positive postsecondary destination is more prevalent in young people living in areas of greater social deprivation, and in males rather than females. The implications for practice, policy and future research are discussed.
الحركة العمرانية والفنية في فرنسا على عهد لويس الرابع عشر1661-1715
Authors: AL-Tikrity Harith A. , Kadoori Al-Naserre Lekaa Monther 
Published: January 2023

عرف عن الشعب الفرنسي رغبته الكبيرة في اظهار كل ما هو جديد ومبتكر في مجالي الاعمار والادب وقد تزامن ذلك مع وجود شخصية لويس الرابع عشر فقد عرف عنه شغفه في اظهار مملكته بأبهى صورة في جميع المجالات ولاسيما العمرانية والفنية، لذلك تم اختيار عنوان البحث بـــــ " الحركة العمرانية والفنية في فرنسا على عهد لويس الرابع عشر 1661-1715" . وتم تقسيمه على ثلاثة محاور ناقش المحور الأول القصور والحدائق العامة، اما المحور الثاني فدرس فنون الأثاث والمقاعد في عهد الملك لويس الرابع عشر، في حين وضح المحور الثالث تطور الحياة الفنية مرحلة استلام العرش .
توصل البحث إلى مجموعة من النتائج اهمها:

لم تشغل الحروب الخارجية والصراعات الداخلية لويس الرابع عشر عن البناء والاعمار والاهتمام بالفنون والآداب .
اظهرت أعماله قوته وصلابته ووسع افقه في التفكير والابداع بطريقة نقلت عموم جماهير الشعب من تعدد الزعماء والقادة والسادة إلى طبيعة الرجل الواحد والسيد الاعلى .
كان حب الملك نفسه للموسيقى والرقص وباقي الفنون اثر اكبر من غيره وذلك لممارسته هو شخصياً لتلك الأعمال وتحديد نواقصها والاعناء بها .
اثبتت أعمال الملك بصورة عامة على مدى رغبته الحقيقية في نقل المملكة إلى مرحلة جديدة من البناء والتطور الفني والادبي .