bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure of muoniated trimethylsilylvinyl radicals
Authors: McKenzie Iain , Percival Paul W 
Published: March 2023

Abstract
Muoniated vinyl radicals can be produced by muonium (Mu) addition to triple bonds. Rhodes et al. observed a muoniated radical formed by Mu addition to trimethylsilylacetylene but were unable to determine the structure (J. Chem. Soc., Chem. Commun.
1987, 447). We have performed transverse field muon spin rotation measurements on trimethylsilylacetylene at 298 K and two different applied magnetic fields and observed that two types of muoniated radical were formed: a major product with muon hyperfine coupling constant (A
µ
) of 587.3(1) MHz and a minor product with A
µ
of 570.9(5) MHz. DFT calculations show that Mu addition is preferred to the terminal carbon of the triple bond and that the two resulting radicals are isomers of the Me3SiĊ =CH(Mu) radical. Calculated muon hyperfine coupling constants were used to assign the observed radicals, which have Mu cis and trans to the trimethylsilyl substituent, respectively.
Are Interventions Efficacious at Increasing Human Papillomavirus Vaccinations Among Adults? A Meta-Analysis
Authors: Fleszar-Pavlović Sara E , Cameron Linda D 
Published: March 2023

Abstract

Background
A variety of intervention strategies to improve Human Papillomavirus (HPV) vaccination rates in adults exist; however, they have shown varying efficacy and inconsistent outcomes.

Purpose
This meta-analysis tested the efficacy of HPV vaccination interventions for adults in increasing vaccine intentions, rates of initiation of the vaccine series, and completion rates. The study also tested potential moderators (intervention strategy, theory-based versus nontheory-based interventions, race/ethnicity, gender, study quality) of relationships between intervention receipt and vaccine intentions.

Method
Electronic databases (PsychINFO, Web of Science, Scopus, EBSCO, JSTOR, PubMed) were searched for English-language articles published up to September 2021. Eligible studies included outcomes of vaccine intentions, receipt of the first dose, or vaccine series completion and included intervention and comparison conditions.

Results
The search yielded 38 eligible studies reporting 78 effect sizes. Random effects, multilevel, meta-analytic models revealed a significant, small effect of interventions on vaccine intentions (OR = 0.36, 95% CI [0.07, 0.65]); a nonsignificant effect on vaccine initiation rates (OR = 1.29; 95% CI [0.87, 1.91]); and significant effects on vaccine completion rates (OR = 1.58, 95% CI [1.18, 2.11]). Race/ethnicity, gender, intervention strategy, theory-based interventions, and study quality did not moderate the intervention effects on vaccine intentions.

Conclusion
Evidence supports the efficacy of interventions to increase intentions to receive the HPV vaccine and completion of the HPV vaccine series in adults. However, evidence did not support the efficacy of interventions to increase HPV vaccine initiation. Findings highlight directions for developing more efficacious HPV vaccine interventions for adults.
Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis
Authors: Sharma Breni , Wang Meng , McCreary Cheryl R , Camicioli Richard , Smith Eric E 
Published: March 2023

AbstractBackgroundGait impairment contributes to falls and frailty. Some studies suggest that cerebral small vessel disease (CSVD) is associated with gait impairment in the general population. We systematically reviewed and meta-analysed the literature on associations of CSVD with gait impairment and falls.MethodsThe protocol was published in PROSPERO (CRD42021246009). Searches of Medline, Cochrane and Embase databases were conducted on 30 March 2022. Cross-sectional and longitudinal studies of community-dwelling adults were included, reporting relationships between diagnosis or neuroimaging markers of CSVD and outcomes related to gait or falls. Partial correlation coefficients were calculated and pooled using a random-effects model for meta-analysis.ResultsThe search retrieved 73 studies (53 cross-sectional; 20 longitudinal). Most studies reported an association between CSVD and gait impairments or falls risk: 7/7 studies on CSVD score or diagnosis, 53/67 studies on white matter hyperintensities (WMHs), 11/21 studies on lacunar infarcts, 6/15 studies on cerebral microbleeds and 1/5 studies on perivascular spaces. Meta-analysis of 13 studies found that higher WMH volume was mildly correlated with lower gait speed, in all studies (r = −0.23, 95% confidence interval: −0.33 to −0.14, P &lt; 0.0001). However, there was significant heterogeneity between studies (I2 = 82.95%; tau2 = 0.02; Q = 79.37, P &lt; 0.0001), which was unexplained by variation in age, sex, study quality or if the study adjusted for age.ConclusionsFindings suggest that CSVD severity is associated with gait impairment, history of falls and risk of future falls. Prevention of CSVD should be part of a comprehensive public health strategy to improve mobility and reduce risk of falls in later life.
Against classical paraconsistent metatheory
Authors: Tanaka Koji , Girard Patrick 
Published: March 2023

AbstractThere was a time when ‘logic’ just meant classical logic. The climate is slowly changing, and non-classical logic cannot be dismissed off-hand. However, a metatheory used to study the properties of non-classical logic is often classical. In this paper, we will argue that this practice of relying on classical metatheories is problematic. In particular, we will show that it is a bad practice because the metatheory that is used to study a non-classical logic often rules out the very logic it is designed to study.
SCREE: a comprehensive pipeline for single-cell multi-modal CRISPR screen data processing and analysis
Authors: Wei Hailin , Han Tong , Li Taiwen , Wu Qiu , Wang Chenfei 
Published: March 2023

Abstract
Single-cell CRISPR screens have been widely used to investigate gene regulatory circuits in diverse biological systems. The recent development of single-cell CRISPR screens has enabled multimodal profiling of perturbed cells with both gene expression, chromatin accessibility and protein levels. However, current methods cannot meet the analysis requirements of different types of data and have limited functions. Here, we introduce Single-cell CRISPR screens data analysEs and perturbation modEling (SCREE) as a comprehensive and flexible pipeline to facilitate the analyses of various types of single-cell CRISPR screens data. SCREE performs read alignment, sgRNA assignment, quality control, clustering and visualization, perturbation enrichment evaluation, perturbation efficiency modeling, gene regulatory score calculation and functional analyses of perturbations for single-cell CRISPR screens with both RNA, ATAC and multimodal readout. SCREE is available at https://github.com/wanglabtongji/SCREE.
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis
Authors: Zhang Jiasi , Liu Yuxi , Li Qun , Zuo Liping , Zhang Bo , Zhao Fei , Fan Fengjuan , Luo Shanshan , Hu Yu , Sun Chunyan 
Published: March 2023

Abstract
Overactive fatty acid metabolism is usually found in hematological malignancies including multiple myeloma (MM), but the underlying mechanisms remain unclear. Here, we reveal that acyl-CoA synthetase long-chain family member 4 (ACSL4) is abnormally overexpressed in MM cell lines and MM patients compared to healthy donors. Knockdown of ACSL4 inhibited MM cell proliferation and reduced fatty acid levels possibly by regulating lipid metabolism genes including c-Myc and sterol regulatory element binding proteins (SREBPs). As a propellent in ferroptosis, ACSL4 also determines the sensitivity of MM cells to ferroptosis inducer RSL3. Knockdown of ACSL4 rendered MM cells resistance to ferroptosis. Our findings suggest that ACSL4 is a double-edged sword target in MM. Based on the high expression of ACSL4, ferroptosis induction represents a promising therapeutic strategy for MM.
Not all errors are created equal: decoding the error-processing mechanisms using alpha oscillations
Authors: Li Qing , Yin Shouhang , Wang Jing , Zhang Mengke , Li Zhifang , Chen Xu , Chen Antao 
Published: March 2023

Abstract
Empirical evidence on error processing comes from the comparison between errors and correct responses in general, but essential differences may exist between different error types. Typically, cognitive control tasks elicit errors without conflicts (congruent errors) and with conflicts (incongruent errors), which may employ different monitoring and adjustment mechanisms. However, the neural indicators that distinguish between both error types remain unclear. To solve this issue, behavioral and electrophysiological data were measured while subjects performed the flanker task. Results showed that a significant post-error improvement in accuracy on incongruent errors, but not on congruent errors. Theta and beta power were comparable between both error types. Importantly, the basic error-related alpha suppression (ERAS) effect was observed on both errors, whereas ERAS evoked by incongruent errors was greater than congruent errors, indicating that post-error attentional adjustments are both source-general and source-specific. And the brain activity in alpha band, but not theta or beta band, successfully decoded congruent and incongruent errors. Furthermore, improved post-incongruent error accuracy was predicted by a measure of post-error attentional adjustments, the alpha power. Together, these findings demonstrate that ERAS is a reliable neural indicator for identifying error types, and directly conduces to the improvement of post-error behavior.
The Present and Future of Lipid Testing in Cardiovascular Risk Assessment
Authors: White-Al Habeeb Nicole M A , Higgins Victoria , Wolska Anna , Delaney Sarah R , Remaley Alan T , Beriault Daniel R 
Published: March 2023

Abstract

Background
Lipids play a central role in the pathogenesis of cardiovascular disease (CVD), a leading cause of morbidity and mortality worldwide. Plasma lipids and lipoproteins are routinely measured to help identify individuals at high risk of developing CVD and to monitor patients’ response to therapy. The landscape of lipid testing is rapidly changing, including new ways to estimate traditional lipid parameters (e.g., low-density lipoprotein-cholesterol [LDL-C] calculations) and new lipid parameters that show superiority for risk prediction (e.g., non-high-density lipoprotein-cholesterol [non-HDL-C], apolipoprotein B [apoB], and lipoprotein a [Lp(a)]).

Content
Various national guidelines for managing dyslipidemia to prevent CVD are available, which primarily focus on LDL-C for identifying those at high risk and setting thresholds for optimal response to therapy. However, LDL-C can be calculated and measured in various ways, each with advantages and disadvantages. Importantly, the recently established Sampson–NIH LDL-C equation appears to be superior to preceding calculations, as is clear from the literature and in guidelines. There is now a shift towards using lipid parameters other than LDL-C, such as non-HDL-C, apoB, and Lp(a), to identify high-risk patients and/or establish treatment targets.

Summary
The goal of this review is to discuss the present and future of lipid testing for CVD risk assessment through describing various national clinical guidelines, critically reviewing methods to calculate and measure LDL-C and discussing the clinical utility of additional lipid parameters.
Growth Differentiation Factor 15: A Prognostic Marker in Patients with Acute Chest Pain without Acute Myocardial Infarction
Authors: Myrmel Gard M S , Steiro Ole-Thomas , Tjora Hilde L , Langørgen Jørund , Bjørneklett Rune , Skadberg Øyvind , Bonarjee Vernon V S , Mjelva Øistein R , Pedersen Eva K R , Vikenes Kjell , Omland Torbjørn , Aakre Kristin M 
Published: March 2023

Abstract

Background
Acute chest pain is associated with an increased risk of death and cardiovascular events even when acute myocardial infarction (AMI) has been excluded. Growth differentiation factor-15 (GDF-15) is a strong prognostic marker in patients with acute chest pain and AMI, but the prognostic value in patients without AMI is uncertain. This study sought to investigate the ability of GDF-15 to predict long-term prognosis in patients presenting with acute chest pain without AMI.

Methods
In total, 1320 patients admitted with acute chest pain without AMI were followed for a median of 1523 days (range: 4 to 2208 days). The primary end point was all-cause mortality. Secondary end points included cardiovascular (CV) death, future AMI, heart failure hospitalization, and new-onset atrial fibrillation (AF).

Results
Higher concentrations of GDF-15 were associated with increased risk of death from all causes (median concentration in non-survivors vs survivors: 2124 pg/mL vs 852 pg/mL, P &lt; 0.001), and all secondary end points. By multivariable Cox regression, GDF-15 concentration ≥4th quartile (compared to &lt;4th quartile) remained an independent predictor of all-cause death (adjusted hazard ratio (HR): 2.75; 95% CI, 1.69–4.45, P &lt; 0.001), CV death (adjusted HR: 3.74; 95% CI, 1.31–10.63, P = 0.013), and heart failure hospitalization (adjusted HR: 2.60; 95% CI, 1.11–6.06, P = 0.027). Adding GDF-15 to a model consisting of established risk factors and high-sensitivity cardiac troponin T (hs-cTnT) led to a significant increase in C-statistics for prediction of all-cause mortality.

Conclusions
Higher concentrations of GDF-15 were associated with increased risk of mortality from all causes and risk of future CV events.
The influence of explicit local dynamics on range expansions driven by long-range dispersal
Authors: Villiger Nathan , Paulose Jayson 
Published: March 2023

Abstract
Range expansions are common in natural populations. They can take such forms as an invasive species spreading into a new habitat or a virus spreading from host to host during a pandemic. When the expanding species is capable of dispersing offspring over long distances, population growth is driven by rare but consequential long-range dispersal events that seed satellite colonies far from the densely occupied core of the population. These satellites accelerate growth by accessing unoccupied territory, and also act as reservoirs for maintaining neutral genetic variation present in the originating population, which would ordinarily be lost to drift. Prior theoretical studies of dispersal-driven expansions have shown that the sequential establishment of satellites causes initial genetic diversity to be either lost or maintained to a level determined by the breadth of the distribution of dispersal distances. If the tail of the distribution falls off faster than a critical threshold, diversity is steadily eroded over time; by contrast, broader distributions with a slower falloff allow some initial diversity to be maintained for arbitrarily long times. However, these studies used lattice-based models and assumed an instantaneous saturation of the local carrying capacity after the arrival of a founder. Real-world populations expand in continuous space with complex local dynamics, which potentially allow multiple pioneers to arrive and establish within the same local region. Here, we evaluate the impact of local dynamics on the population growth and the evolution of neutral diversity using a computational model of range expansions with long-range dispersal in continuous space, with explicit local dynamics that can be controlled by altering the mix of local and long-range dispersal events. We found that many qualitative features of population growth and neutral genetic diversity observed in lattice-based models are preserved under more complex local dynamics, but quantitative aspects such as the rate of population growth, the level of maintained diversity, and the rate of decay of diversity all depend strongly on the local dynamics. Besides identifying situations in which modeling the explicit local population dynamics becomes necessary to understand the population structure of jump-driven range expansions, our results show that local dynamics affects different features of the population in distinct ways, and can be more or less consequential depending on the degree and form of long-range dispersal as well as the scale at which the population structure is measured.
Average dwell time based networked predictive control for switched linear systems with data transmission time-varying delays
Authors: Cui Yanliang , Shi Guangtian , Xu Lanlan , Ji Juanjuan 
Published: March 2023

AbstractThis paper investigates an average dwell time (ADT) based networked predictive control for discrete-time linear systems with data transmission time-varying delays. Since the data transmission time-varying delays and packet dropouts simultaneously exhibit in the sensor-to-controller and the controller-to-actuator channels, a predictor is proposed to approximate the current state with the delayed state measurement. Based on the estimation state, a synchronous switching controller is proposed, and its mode-dependent and mode-independent design methods are presented. The proposed methods not only guarantee the desired stability of the closed-loop systems but also tolerate some locally unstable subsystems. In addition, the decay rate of the closed-loop system can be pre-regulated. Moreover, given some prior activation probabilities of subsystems, the ADT can be further reduced, thus more frequent switching dynamics can be allowed. Numerical example is provided to show the effectiveness of the developed method.
The circadian neutrophil, inside-out
Authors: Ovadia Samuel , Özcan Alaz , Hidalgo Andrés 
Published: March 2023

Abstract
The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil–circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity.
Relative influence of inter- and intraspecific competition in an ungulate assemblage modified by introduced species
Authors: Zini Valentina , Wäber Kristin , Dolman Paul M 
Published: March 2023

Abstract
Interspecific competition from introduced and naturally colonizing species has potential to affect resident populations, but demographic consequences for vertebrates have rarely been tested. We tested hypotheses of interspecific and intraspecific competition for density, body mass, and fertility of adult female Roe Deer (Capreolus capreolus) across a heterogeneous forest landscape occupied by two introduced deer species: Mediterranean Fallow Deer (Dama dama); and subtropical Reeve’s Muntjac (Muntiacus reevesi). Species-specific deer densities in buffers around culling locations of 492 adult female Roe Deer, sampled over seven years, were extracted from spatially explicit models calibrated through annual nocturnal distance sampling. Roe Deer fertility and body mass were related to species-specific deer densities and extent of arable lands using piecewise structural equation models. Reeve’s Muntjac density was lower at higher Fallow Deer densities, suggesting interspecific avoidance via interference competition, but greater when buffers included more arable land. Roe Deer body mass was marginally greater when buffers included more arable land and was independent of deer densities. However, Roe Deer fertility was unrelated to female body mass, suggesting that fertility benefits exceeded an asymptotic threshold of body condition in this low-density population. However, Roe Deer fertility was slightly greater rather than reduced in areas with greater local Roe Deer density, suggesting negligible intraspecific competition. In contrast, Roe Deer was less fertile in areas with greater Reeve’s Muntjac densities; thus, interspecific exceeded intraspecific competition in this assemblage. In contrast, we found no support for any effects of Fallow Deer density on Roe Deer density, body mass, or fertility. Complex networks of interspecific competition operating in this deer assemblage include: interspecific interference from Fallow Deer exceeded habitat effects for Reeve’s Muntjac; and interspecific competition from introduced, smaller sedentary Reeve’s Muntjac reduced fertility, unlike intraspecific, or potential competition with larger, more mobile, Fallow Deer for native Roe Deer. Mechanisms driving Roe Deer fertility may include interspecific behavioral interference or stress–resource depletion is considered less likely because Roe Deer fertility was independent of body mass. Findings emphasize the importance of ensuring appropriate management strategies for controlling invasive species.
Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing
Authors: Bi Chongwei , Wang Lin , Fan Yong , Yuan Baolei , Ramos-Mandujano Gerardo , Zhang Yingzi , Alsolami Samhan , Zhou Xuan , Wang Jincheng , Shao Yanjiao , Reddy Pradeep , Zhang Pu-Yao , Huang Yanyi , Yu Yang , Izpisua Belmonte Juan Carlos , Li Mo 
Published: March 2023

Abstract
The ontogeny and dynamics of mtDNA heteroplasmy remain unclear due to limitations of current mtDNA sequencing methods. We developed individual Mitochondrial Genome sequencing (iMiGseq) of full-length mtDNA for ultra-sensitive variant detection, complete haplotyping, and unbiased evaluation of heteroplasmy levels, all at the individual mtDNA molecule level. iMiGseq uncovered unappreciated levels of heteroplasmic variants in single cells well below the conventional NGS detection limit and provided accurate quantitation of heteroplasmy level. iMiGseq resolved the complete haplotype of individual mtDNA in single oocytes and revealed genetic linkage of de novo mutations. iMiGseq detected sequential acquisition of detrimental mutations, including large deletions, in defective mtDNA in NARP/Leigh syndrome patient-derived induced pluripotent stem cells. iMiGseq identified unintended heteroplasmy shifts in mitoTALEN editing, while showing no appreciable level of unintended mutations in DdCBE-mediated mtDNA base editing. Therefore, iMiGseq could not only help elucidate the mitochondrial etiology of diseases, but also evaluate the safety of various mtDNA editing strategies.