bluuebunny/crossref_metadata_2025_split huggingface dataset:
The patient burden of nocturnal polyuria in the United States: Results from the epidemiology of nocturnal polyuria (EpiNP) study
Authors: Chapple Christopher R. , Rosenberg Matt T. , Mueller Elizabeth R. , Chughtai Bilal , Weiss Jeffrey P. , Juul Kristian , Brooks Anne B. , Bacci Elizabeth D. , Andersson Fredrik L. , Coyne Karin S. , Bosch JLH Ruud 
Published: January 2023

AbstractObjectivesTo explore the impact of nocturnal polyuria (NP) on health‐related quality of life (HRQoL), work productivity, mental health, fatigue, bother, and daytime sleepiness.Materials and MethodsThis large‐scale, US population‐representative epidemiologic study was conducted in two parts: a web‐based survey and 3‐day bladder diary. Consenting participants completed the baseline Epidemiology of NP (EpiNP) survey online (Lower Urinary Tract Symptoms [LUTS] Tool, comorbidities, burden, and multiple HRQoL measures). Participants who reported ≥2 voids/night, and a random sample of 100 respondents each reporting 0 or 1 void/night, were sent urine measurement containers and asked to complete the 3‐day bladder diary. NP was defined as Nocturnal Polyuria Index >0.33 (NPI33) or nocturnal urine production >90 ml/h (NUP90). Five subgroups were created: Idiopathic NP (NP with no underlying cause), NP associated with symptoms of overactive bladder (NPOAB) or bladder outlet obstruction (NPBOO; men only), NP associated with other comorbidities (NPCOM; e.g., diabetes, hypertension, heart disease, sleep apnea), and no NP (did not meet NP criteria).ResultsA total of 4893 men and 5297 women completed the EpiNP survey; mean age was 54.4 (SD = 14.7). Significantly greater patient burden (p < 0.0001) was evidenced in the nocturia group (≥2 voids/night) versus no nocturia group (0–1 void/night) on daily impact of nocturia, LUTS Bother, prostate symptoms (men only), work productivity, physical and mental health component scores, depression, fatigue, and daytime sleepiness. NP subgroup analyses showed men in the NPBOO group and women in the NPOAB group reported the greatest impact on LUTS bother, fatigue, physical health, work productivity impairment, daytime sleepiness, and depression (women only).ConclusionThis was the first large‐scale, epidemiologic study to explore the impact of different forms of NP on patients' HRQoL. Findings demonstrate that NP associated with other urologic or comorbid conditions appears to have greater patient burden than idiopathic NP, in particular for women.
Sleep Disorders, Comorbidities, Actions, Lower Urinary Tract Dysfunction, and Medications (“Sleep C.A.L.M.”) in the evaluation and management of nocturia: A simple approach to a complex diagnosis
Authors: Monaghan Thomas F. , Weiss Jeffrey P. , Wein Alan J. , Rahman Syed N. , Lazar Jason M. , Bliwise Donald L. , Everaert Karel , Lemack Gary E. , Cornu Jean‐Nicolas , Drake Marcus J. , Chapple Christopher R. , Hashim Hashim , Blaivas Jerry G. , Dmochowski Roger R. 
Published: January 2023

AbstractIntroductionNocturia arises from a fundamental mismatch between nocturnal urine production, storage capacity, and sleep architecture, which may be driven by abnormalities of the genitourinary tract, but also by sleep disorders, medical diseases, patient actions/lifestyle factors, or medications. This article introduces a novel system for organizing the complex differential diagnosis for nocturia, as proposed by an international collective of practicing urologists, physician specialists, and sleep experts: “Sleep CALM”—Sleep Disorders, Comorbidities, Actions, Lower Urinary Tract Dysfunction, and Medications.MethodsNarrative review of current evidence regarding the relevance of each “Sleep CALM” factor to nocturia pathogenesis, evaluation, and management.ResultsNocturia and sleep disorders are highly intertwined and often bidirectional, such that nocturnal awakenings for reasons other than a sensation of bladder fullness should not be used as grounds for exclusion from nocturia treatment, but rather leveraged to broaden therapeutic options for nocturia. Nocturia is an important potential harbinger of several serious medical conditions beyond the genitourinary tract. Urologists should have a low threshold for primary care and medical specialty referral for medical optimization, which carries the potential to significantly improve nocturnal voiding frequency in addition to overall health status. Adverse patient actions/lifestyle factors, lower urinary tract dysfunction, and medication use commonly coexist with disordered sleep and comorbid medical conditions, and may be the primary mediators of nocturia severity and treatment response, or further exacerbate nocturia severity and complicate treatment.Conclusion“Sleep CALM” provides a memorable and clinically relevant means by which to structure the initial patient history, physical exam, and clinical testing in accordance with current best‐practice guidelines for nocturia. Although not intended as an all‐encompassing diagnostic tool, the “Sleep CALM” schema may also be useful in guiding individualized ancillary testing, identifying the need for specialty referral and multidisciplinary care, and uncovering first‐line treatment targets.
Patterns of Lymph Node Metastasis in Parotid Cancer and Implications for Extent of Neck Dissection
Authors: Voora Rohith S. , Panuganti Bharat , Califano Joseph , Coffey Charles , Guo Theresa 
Published: January 2023

AbstractObjectiveThe role and extent of neck dissection in primary parotid cancer are controversial. Herein, we characterize patterns of lymph node metastasis in parotid cancer.Study DesignRetrospective analysis.SettingNational Cancer Database.MethodsPatients with the 6 most common histologic subtypes of parotid cancer were selected. Primary outcomes were the distribution of positive lymph nodes by level and overall survival assessed by Cox analysis. Secondary outcomes included predictors of extended lymph node involvement (≥3 lymph nodes or Level IV/V involvement), via logistic regression.ResultsSix thousand nine hundred seventy‐seven patients with acinic cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, carcinoma ex pleomorphic adenoma (CExPA), mucoepidermoid carcinoma, and salivary duct carcinoma (SDC) were included. Among cN0 patients, 8.2% of low‐grade tumor patients had occult nodal metastasis versus 30.9% in high‐grade tumor patients. Elective neck dissection was not associated with an overall survival benefit (adjusted hazard ratio: 1.10; 0.94‐1.30, p = .238). Among cN+ tumors, CExPA (odds ratio [OR]: 1.88, 1.05‐3.39, p = .034) and high‐grade pathology (OR: 3.03, 1.87‐4.93, p < .001) were predictive of having ≥3 pathologic nodes. CExPA (OR: 2.13, 1.22‐3.72, p = .008), adenocarcinoma (OR: 1.60, 1.11‐2.31, p = .013), SDC (OR: 1.92, 1.17‐3.14, p < .01), and high‐grade pathology (OR: 3.61, 2.19‐5.97, p < .001) were predictive of Level IV/V neck involvement.ConclusionsIn parotid malignancy, nodal metastasis distribution is dependent on histology and grade. High‐grade tumors and certain histologies (SDC and adenocarcinoma) had a higher incidence of occult nodes. Comprehensive neck dissection should also be considered for node‐positive high‐grade tumors, SDC, and adenocarcinoma.
Office‐Based Photodynamic Therapy Using Locally Applied 5‐aminolevulinic Acid and 635 nm Laser for Laryngeal Leukoplakia
Authors: Zhang Chi , Zhong Jingting , Jiang Jack J. , Hou Qian , Ren Hui , Silverman Matthew , Li Gelin 
Published: January 2023

AbstractObjectivePhotodynamic therapy (PDT) is a minimally invasive method with strong tissue selectivity and nonthermal effects. We aim to investigate the efficacy of an in‐office method utilizing PDT with local application of 5‐aminolevulinic acid (ALA) and 635 nm diode laser for treating laryngeal leukoplakia.Study DesignRetrospective cohort study.SettingOutpatient clinic‐tertiary medical center.MethodsThis study reviewed 32 patients with laryngeal leukoplakia, including 11 recurrent cases after surgery. All the procedures were performed in an office setting under topical anesthesia. Fifteen percent ALA solution was locally applied to the lesion through a flexible laryngoscope. Light illumination was performed using a 635 nm diode laser through a 400 μm optic fiber. The power density was 165 mW/cm2 to reach 100 J/cm2. Results of laryngostroboscopy and voice evaluation during follow‐up were collected.ResultsThe mean follow‐up was 7.91 ± 4.83 (3‐18) months. Thirty‐nine procedures were performed, including 1 session for 27 patients, 2 sessions for 3 patients, and 3 sessions for 2 patients. The total response rate was 96.875% (31/32), including complete responses in 26 (81.25%) patients, partial responses in 5 patients (15.625%), and no response in 1 patient (3.125%). It appeared that PDT selectively eliminated the leukoplakia without affecting lamina propria and the surrounding normal mucosa remained unharmed. Scores of Voice Handicap Index‐10, jitter, shimmer, and harmonic‐to‐noise ratio were significantly improved after PDT.ConclusionOffice‐based PDT is an effective, repeatable, and practical method for treating laryngeal leukoplakia. Local application of ALA is sufficient to achieve photodynamic reactions. PDT could eliminate laryngeal leukoplakia selectively while protecting the normal laryngeal structure.
Impact of Sociodemographic Disparities on Language Outcomes After Cochlear Implantation in a Diverse Pediatric Cohort
Authors: Liao Elizabeth N. , Yaramala Naveen , Coulthurst Sarah , Merrill Kris , Ho Melissa , Kramer Kurt , Chan Dylan K. 
Published: January 2023

AbstractObjectiveWe examined how sociodemographic and audiologic factors affect receptive and expressive language outcomes in children with cochlear implantation.Study DesignRetrospective cohort study.SettingA hearing loss (HL) clinic at a tertiary center.MethodsSociodemographic variables, HL characteristics, age at implantation, and receptive language scores (Preschool Language Scale and the Clinical Evaluation of Language Fundamentals) were collected from patients with congenital HL who received their first implant by 4 years old after January 1, 2007. t Tests, linear regression, Mann‐Whitney, Cohen's d, and mediation analysis were used for descriptive statistics and hypothesis testing.ResultsAmong 79 patients, 42 (53%) were females, 44 (56%) under‐represented minorities, and 56 (71%) had public insurance. At least 1 year after implantation, the median receptive language score was 69 (range 50‐117). Females (p = .005), having private insurance (p = .00001), having a Cochlear Implant Profile score below 4 (p = .0001), and receiving their implant at or before 12 months of age (p = .0009) were significantly associated with improved receptive language outcomes. Insurance type had a significant effect on receptive language outcomes, independent from age at first implantation (total effect: coef = −13.00, p = .02; direct effect: coef = −12.26, p = .03; indirect effect: coef = −0.75, p = .47). Sociodemographic variables had large effect sizes, with the Cochlear Implant Profile score having the largest effect size (d = 1.3).ConclusionSociodemographic factors have a large impact on receptive language outcomes. Public insurance is associated with worse receptive language, not mediated by later age at implantation, suggesting that other factors primarily impact language outcomes in publicly insured children with cochlear implants.
Portable Sleep Study Device Versus Polysomnography: A Meta‐analysis
Authors: Cagle Joshua L. , Young Benjamin D. , Shih Michael C. , Nguyen Shaun A. , Meyer Ted A. , White David R. , Clemmens Clarice S. 
Published: January 2023

AbstractObjectiveTo provide an updated comparison of apnea‐hypopnea index (AHI), oxygen desaturation index (ODI), respiratory disturbance index (RDI), oxygen saturation (O2 sat), and lowest oxyhemoglobin saturation (LSAT) measured by portable sleep study devices (PSSDs) compared to polysomnography (PSG).Data SourcesPrimary studies were identified through PubMed, Scopus, CINAHL, and Cochrane.Review MethodsA systematic review was performed by searching databases from inception through August 2021. Only studies examining simultaneous monitoring of a PSSD and PSG were included. Respiratory indices AHI, ODI, RDI, O2 sat, and LSAT was collected Meta‐correlations and meta‐regressions were conducted to compare sleep variable measurements between PSSD and PSG.ResultsA total of 24 studies (N = 1644 patients) were included. The mean age was 49.5 ± 12.0 (range = 13‐92), mean body mass index (BMI) was 30.4 ± 5.7 (range = 17‐87), and 69.4% were male. Meta‐correlation showed significant associations between PSSD and PSG for AHI (n = 655, r = .888; p < .001), ODI (n = 241, r = .942; p < .001), RDI (n = 313, r = .832; p < .001), O2 sat (n = 171, r = .858; p < .001), and LSAT (n = 197, r = .930; p < .001). Meta‐regressions indicated significant predictive correlations for AHI (n = 655; r = .96; p < .001), ODI (n = 740; r = .75; p = .031), RDI (n = 197; r = .99; p = .005), and LSAT (n = 197; r = .85; p = .030), but not for O2 sat (n = 171; r = .31; p = .692).ConclusionsRespiratory indices correlate strongly between PSSD and PSG, which is further supported by meta‐regressions results. PSSD might be a valuable cost and time‐saving OSA screening tool.
High Tracheal Resection With Intralaryngeal Extension as an Alternative to Cricotracheal Resection for Treatment of Subglottic Stenosis
Authors: Liang Kevin Y. , Nelson Rebecca C. , Bryson Paul C. , Lorenz Robert R. 
Published: January 2023

AbstractObjectiveSome patients with subglottic stenosis (SGS) require open airway reconstruction, which traditionally involves resection of the anterior cricoid cartilage. As an alternative, we present a novel technique: cricoid‐sparing high tracheal resection with excision of subglottic stenotic tissue from below. A novel set of posterior circumferential cricoid sutures is used to reline the exposed cricoid plate.Study DesignRetrospective chart review.SettingSingle tertiary care center.MethodsThe surgical technique is described and illustrated. A chart review was performed for all patients who underwent surgery between January 1, 2016, and June 30, 2021.ResultsFourteen patients (100% female) underwent this airway resection and reconstruction surgery during the study time period. After a mean follow‐up of 12 months, no patients required tracheostomy. Twelve of 14 patients (86%) had durable airways. Two patients (14%) have required repeated endoscopic procedures for recurrent stenosis and are considered treatment failures. None exhibited postoperative dysfunction to suggest posterior cricoarytenoid muscle injury. Thirteen patients (93%) had a postoperative normal voice or only transient dysphonia. One patient had permanent unilateral vocal fold paralysis.ConclusionCricoid‐sparing high tracheal resection is a safe and effective alternative to cricotracheal resection, especially for predominantly posterior SGS. The cricoid cartilage and cricothyroid muscles are left undisturbed, potentially decreasing the risk of postoperative dysphonia, namely lowered fundamental frequency. This is especially meaningful in the setting of a predominantly female patient population.
Current Status of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: A Review
Authors: Aktar Sharmin , Baghaie Hooman , Islam Farhadul , Gopalan Vinod , Lam Alfred King‐Yin 
Published: January 2023

AbstractObjectiveCirculating tumor cells (CTCs) are found in the blood of patients with cancer, including head and neck squamous cell carcinomas (HNSCCs). The aim is to review the most up‐to‐date status of CTCs for applications in patients with HNSCC.Data SourcesEnglish articles in PubMed.Review MethodsAll the studies on CTCs in HNSCCs in the literature were reviewed.ConclusionsThere is emerging information on the diagnostic and prognostic value of CTCs in HNSCCs. Evidence also highlights the advantages of various downstream analysis approaches over circulating tumor DNA (ctDNA), such as single‐CTC analysis, ex vivo, and in vivo expansion of CTCs. Multiple phenotypic surface markers (cytokeratins, EpCAM, vimentin, etc.), used for CTCs characterization using different immunoassays, could predict disease progression as well as patients' response to treatment efficacy. Immune checkpoint inhibitors' status in CTCs could also provide better insight into treatment. Clonal expansion of CTCs and single‐cell analysis of CTCs are the most emerging fields nowadays which may offer an understanding of the mechanism of tumor evolution as well as therapeutic efficacy. Although several clinical trials are ongoing, limitations still exist in the detection and characterization of CTCs. Due to the lack of a gold standard protocol, the sensitivity and specificity of CTC enumeration methods vary.Implications for PracticeProspective clinical trials are still needed before CTCs can be employed as diagnostic and prognostic markers in the clinical management of patients with HNSCC.
Going Off Guidelines: An NCDB Analysis of Missed Adjuvant Therapy Among Surgically Treated Oral Cavity Cancer
Authors: Tassone Patrick , Topf Michael C. , Dooley Laura , Galloway Tabitha , Biedermann Gregory , Trendle Michael 
Published: January 2023

AbstractObjectivePatient factors associated with failure to receive adjuvant therapy after oral cavity cancer resection remain understudied. Here, we identified rates of missed adjuvant therapy, determined factors associated with missed therapy, and assessed associations with survival.Study DesignRetrospective cohort.SettingNational Cancer Database.MethodsPatients with resected oral cavity squamous cell carcinoma and known adjuvant therapy status were included. T3‐4 stage, N2‐3 stage, and lymphovascular invasion were considered indications for adjuvant radiation. Extranodal extension or positive margins were considered indications for chemoradiation. Patient factors were examined for associations with missed adjuvant therapy. Overall survival was evaluated by Cox proportional hazard analysis.ResultsA total of 53,503 patients were included. 27.5% missed adjuvant therapy altogether, and 26.7% with a documented indication for chemoradiation missed chemotherapy. Factors associated with missed adjuvant therapy were age, white race, low income, metropolitan population, increasing comorbidities, travel distance, lip primary, and treatment at the academic facility. Factors associated with missed chemotherapy were age, female sex, nontongue subsite, and treatment at a nonacademic center. Among patients with indications for adjuvant radiation, missed radiation was associated with worse overall survival (hazard ratio [HR]: 1.42, 95% confidence interval [CI]: 1.31‐1.53). Among patients with indications for adjuvant chemoradiation, missed chemotherapy was associated with worse overall survival (HR: 1.19, 95% CI: 1.09‐1.29).ConclusionMissed adjuvant therapy occurs frequently after oral cavity resection. Patients treated at academic centers may be at risk of missed therapy related to travel distance, though these patients are more likely to receive adjuvant chemotherapy when indicated. Missed adjuvant therapy is associated with worse survival.
Polylactide/poly[(R)‐3‐hydroxybutyrate] (PHB) blend fibers with superior heat‐resistance: Effect ofPHBon crystallization
Authors: Huang Wei , Shi Yamin , Wang Wenling , Sheng Yongji , Guo Yuying , Li Yi , Yang Qiu , Chen Peng 
Published: January 2023

AbstractBlending low content of poly[(R)‐3‐hydroxybutyrate‐co‐4‐hydroxybutyrate] (P34HB ≤8 wt %) with poly(L‐lactide) (PLLA) has proven effective in enhancing heat resistance of PLLA fibers. Unfortunately, the enhancement is relatively limited with boiling water shrinkage of PLLA/P34HB blend fibers reduced to 9.9% at most. In this study, a series of PLLA/poly[(R)‐3‐hydroxybutyrate] (PHB) blend fibers with low PHB content (≤8 wt %) was prepared with sound spinnability. Surprisingly, the PLLA/PHB blend fibers showed much lower boiling water shrinkage than the PLLA/P34HB blend fibers with the same blend ratio. In particular, the boiling water shrinkage was dropped from ca. 80% for neat PLLA fibers to 9.9% for the PLA/P34HB blend fibers and further to 3.8% for the PLA/PHB blend fibers with 8 wt % P34HB or PHB added. Such an exceptionally improved heat resistance of the PLLA/PHB blend fibers could be closely related to an increase in crystallinity (Xc,PLLA) of the PLLA phase. Specifically, the mobility of the PLLA segments was promoted in the presence of PHB, along with notably improved orientation of the PLLA phase in the PLLA/PHB blend fibers. More importantly, investigation on crystallization behaviors revealed that the PHB phase served as an effective nucleating agent to accelerate the overall crystallization of PLLA. By contrast, the P34HB phase only acted as spherulite growth‐accelerating and/or nucleation‐assisting agents. These findings help provide a facile and effective strategy to improve heat resistance of PLLA fibers more significantly.
Loss of the crumbs cell polarity complex disrupts epigenetic transcriptional control and cell cycle progression in the developing retina
Authors: Owen Nicholas , Toms Maria , Tian Yuan , Toualbi Lyes , Richardson Rose , Young Rodrigo , Tracey‐White Dhani , Dhami Pawan , Beck Stephan , Moosajee Mariya 
Published: January 2023

AbstractThe crumbs cell polarity complex plays a crucial role in apical–basal epithelial polarity, cellular adhesion, and morphogenesis. Homozygous variants in human CRB1 result in autosomal recessive Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP), with no established genotype–phenotype correlation. The associated protein complexes have key functions in developmental pathways; however, the underlying disease mechanism remains unclear. Using the oko meduzym289/m289 (crb2a−/−) zebrafish, we performed integrative transcriptomic (RNA‐seq data) and methylomic [reduced representation bisulphite sequencing (RRBS)] analysis of whole retina to identify dysregulated genes and pathways. Delayed retinal cell specification was identified in both the crb2a−/− zebrafish and CRB1 patient‐derived retinal organoids, highlighting the dysfunction of cell cycle modulation and epigenetic transcriptional control. Differential DNA methylation analysis revealed novel hypermethylated pathways involving biological adhesion, Hippo, and transforming growth factor β (TGFβ) signalling. By integrating gene expression with DNA methylation using functional epigenetic modules (FEM), we identified six key modules involving cell cycle control and disturbance of TGFβ, bone morphogenetic protein (BMP), Hippo, and SMAD protein signal transduction pathways, revealing significant interactome hotspots relevant to crb2a function and confirming the epigenetic control of gene regulation in early retinal development, which points to a novel mechanism underlying CRB1‐retinopathies. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Bending property of novel 3D woven variable thickness composites: Experiment and finite element analysis
Authors: Liu Ao , Zhou Xinghai , Gao Yuan , Wang Ying , Xiong Xiaoqing , Lyu Li‐hua 
Published: January 2023

AbstractVariable thickness composites are essential engineering materials which have been used in various high‐performance products. However, the commonly used variable thickness composites are mainly lamination, which is prone to delamination and reduce the overall performance under load. To solve this problem, 3D woven fabrics with integrity and continuous variable thickness have been designed and weaved on ordinary looms using basalt yarns. The resin‐based variable thickness composites have been prepared by vacuum‐assisted resin transfer molding (VARTM) process, and two different laminated composites have been produced for comparison. Compared with the two kinds of laminations, the bending strength of the 3D woven variable thickness (3DWVT) composites is increased by 12.28% and 16.22% under positive load; 16.74% and 17.08% under negative load. Finally, the meso‐finite element simulation analysis of the bending performance of 3DWVT composites was carried out by using the meso‐finite element analysis (FEA), and the damage mechanism and failure mode were explored.