bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disable access compliance to university infrastructure: built environment students’ perceptions
Authors: Amoah Christopher , Bamfo-Agyei Emmanuel , Simpeh Fredrick 
Published: May 2023

PurposeHigher education institutions are the citadel of knowledge and are heavily involved in formulating building regulations and building infrastructure designs that must conform to the building regulations. The study aims to identify university infrastructures compliant with disabled access from the perspective of the built environment students in Ghanaian universities.Design/methodology/approachQuestionnaire surveys were administered to 500 built environment students across ten technical universities in Ghana with a total population of 3066; 341 were expected based on the formula used. However, upon several reminders, 176 responded. Data collected were analysed using Statistical Package for the Social Sciences.FindingsThe findings show that all university facilities are not fully compliant with disabled access. Structures found to be least compliant are the laboratories, canteens, hall of residence, toilet facilities, football fields, places of worship and transport stations. The facilities with high compliance are the administration block, library, hospital building, lecture halls, department offices and ATM areas. The leading causes for this non-compliant are lack of enforcement of the building regulations, low level of disabled students’ enrolment, age of the building, lack of knowledge and poor building designs.Practical implicationsCompliance with disabled access makes universities world class and creates safe learning spaces for individuals with disabilities, enforcing the right to education for all individuals, particularly those with disabilities. Lack of compliance with disabled access will hamper the full utilisation of these facilities, thereby affecting quality education delivery to people with disabilities.Originality/valueThe findings are essential to the Ghanaian built environment, the lives of disabled individuals and universities. The results provide knowledge on areas of improvement for complete access to structures and facilities by disabled individuals.
Preparation of cool composite pigment by the layer-by-layer assembling of phthalocyanine green on the surface of rutile TiO2
Authors: Cao Lingyun , Ren Shuaibin , Zhou ZhengHao , Fei Xuening , Huang Changliang 
Published: May 2023

Purpose
This study aims to fabricate a cool phthalocyanine green/TiO2 composite pigment (PGT) with high near-infrared (NIR) reflectance, good color performance and good heat-shielding performance under sunlight and infrared irradiation.

Design/methodology/approach
With the help of anionic and cationic polyelectrolytes, the PGT composite pigment was prepared using a layer-by-layer assembly method under wet ball milling. Based on the light reflectance properties and color performance tested by ultraviolet-visible-NIR spectrophotometer and colorimeter, the preparation conditions were optimized and the properties of PGT pigment with different assembly layers (PGT-1, PGT-3, PGT-5 and PGT-7) were compared. In addition, their heat-shielding performance was evaluated and compared by temperature rise value for their coating under sunlight and infrared irradiation.

Findings
The PGT pigment had a core/shell structure, and the PG thickness increased with the self-assembly layers, which made the PGT-3 and PGT-7 pigment show higher color purity and saturation than PGT-1 pigment. In addition, the PGT-3 and PGT-7 pigment showed 11%–16% lower light reflectance in the visible region. However, their light reflectance in the NIR region was similar. Under infrared irradiation the PGT-5 and PGT-7 pigment coating showed 1.1°C–3.4°C and 1.3°C–4.7°C lower temperature rise value than PGT-1 pigment coating and physical mixture pigment coating, respectively. And under sunlight the PGT-3 pigment coating showed 1.5–2.6°C lower temperature rise value than the physical mixture pigment coating.

Originality/value
The layer-by-layer assembling makes the core/shell PGT composite pigment possess low visible light reflectance, high NIR reflectance and good heat-shielding performance.
The role of resin in optimizing the performance and printing properties of water-based inkjet inks for food packaging
Authors: Kusber Aniela , Gaida Rafał Józef , Dziubek Katarzyna , Wit Marian 
Published: May 2023

Purpose
This study aims to investigate the influence of commercially available resins in water-based magenta pigment inkjet ink formulations on the properties of ink printability and the characteristics of ink application in food packaging. The impact of the resin on the jettability of the existing printability phase diagrams was also assessed.

Design/methodology/approach
Inks with different resin loadings were tested for selected properties, such as viscosity, particle size and surface tension. Stability was determined using a Turbiscan AGS turbidimeter and LumiFuge photocentrifuge analyzer. The ink layer fastness against abrasion and foodstuffs was evaluated using an Ugra device and according to PN-EN 646, respectively. JetXpert was used to assess Ricoh printhead jetting performance.

Findings
Printability diagrams successfully characterized the jettability of polyurethane inkjet inks on a multi-nozzle printhead and the binder improved droplet formation and printing precision.

Originality/value
Magenta water-based inkjet inks with commercial resins have been developed for printing on paper substrates. To the best of the authors’ knowledge, for the first time, inkjet ink stability was evaluated using the Turbiscan AGS and LumiFuge analyzers, and jettability models were verified using an industrial multi-nozzle printhead.
PLOD2 promotes colorectal cancer progression by stabilizing USP15 to activate the AKT/mTOR signaling pathway
Authors: Lan Jiawen , Zhang Sijing , Zheng Lin , Long Xiaoli , Chen Jianxiong , Liu Xunhua , Zhou Miao , Zhou Jun 
Published: May 2023

AbstractProcollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 2 (PLOD2) has been reported as an oncogenic gene, affecting various malignant tumors, including endometrial carcinoma, osteosarcoma, and gastric cancer. These effects are mostly due to the enhanced deposition of collagen precursors. However, more studies need to be conducted on how its lysyl hydroxylase function affects cancers like colorectal carcinoma (CRC). Our present results showed that PLOD2 expression was elevated in CRC, and its higher expression was associated with poorer survival. Overexpression of PLOD2 also facilitated CRC proliferation, invasion, and metastasis in vitro and in vivo. In addition, PLOD2 interacted with USP15 by stabilizing it in the cytoplasm and then activated the phosphorylation of AKT/mTOR, thereby promoting CRC progression. Meanwhile, minoxidil was demonstrated to downregulate the expression of PLOD2 and suppress USP15, and the phosphorylation of AKT/mTOR. Our study reveals that PLOD2 plays an oncogenic role in colorectal carcinoma, upregulating USP15 and subsequently activating the AKT/mTOR pathway.
Risk factors for the development of sepsis in patients with cirrhosis in intensive care units
Authors: Kou Yan‐qi , Yang Yu‐ping , Du Shen‐shen , Liu Xiongxiu , He Kun , Yuan Wei‐nan , Nie Biao 
Published: May 2023

AbstractSepsis is a serious complication of liver cirrhosis. This study aimed to develop a risk prediction model for sepsis among patients with liver cirrhosis. A total of 3130 patients with liver cirrhosis were enrolled from the Medical Information Mart for Intensive Care IV database, and randomly assigned into training and validation cohorts in a 7:3 ratio. The least absolute shrinkage and selection operator (LASSO) regression was used to filter variables and select predictor variables. Multivariate logistic regression was used to establish the prediction model. Based on LASSO and multivariate logistic regression, gender, base excess, bicarbonate, white blood cells, potassium, fibrinogen, systolic blood pressure, mechanical ventilation, and vasopressor use were identified as independent risk variables, and then a nomogram was constructed and validated. The consistency index (C‐index), receiver operating characteristic curve, calibration curve, and decision curve analysis (DCA) were used to measure the predictive performance of the nomogram. As a result of the nomogram, good discrimination was achieved, with C‐indexes of 0.814 and 0.828 for the training and validation cohorts, respectively, and an area under the curve of 0.849 in the training cohort and 0.821 in the validation cohort. The calibration curves demonstrated good agreement between the predictions and observations. The DCA curves showed the nomogram had significant clinical value. We developed and validated a risk‐prediction model for sepsis in patients with liver cirrhosis. This model can assist clinicians in the early detection and prevention of sepsis in patients with liver cirrhosis.
Normal range of intraoperative three‐dimensionally derived right ventricular free‐wall strain in coronary artery bypass surgery patients
Authors: Labus Jakob , Winata Johan , Schmidt Torsten , Nicolai Joachim , Zwaag Stanislaw Vander , Sveric Kunislav , Wilbring Manuel , Scholz Markus , Fassl Jens 
Published: May 2023

AbstractBackgroundData on intraoperative three‐dimensionally derived right ventricular free‐wall strain (3D‐RV FWS) is sparse.ObjectivesWe sought to evaluate the normal range of intraoperative 3D‐RV FWS in patients scheduled for coronary artery bypass graft (CABG) surgery and compared to conventional echocardiographic parameters. Prospective observational study.MethodsA total of 150 patients with preserved left and right ventricular (RV) function and sinus rhythm, without significant heart valve disease or pulmonary hypertension undergoing isolated on‐pump CABG surgery, with an uneventful, complication‐free intraoperative course. 3D‐RV FWS analysis and conventional echocardiographic assessment of RV function were performed intraoperatively in anesthetized and ventilated patients using transesophageal echocardiography (TEE). TomTec 4D RV‐Function 2.0 software for assessment of 3D‐RV FWS and three‐dimensional right ventricular ejection fraction (3D‐RV EF). Philips QLAB 10.8 was used to evaluate tissue velocity of the tricuspid annulus (RV S´), tricuspid annular systolic excursion (TAPSE), and RV fractional area change (FAC). All echocardiographic measurements were performed under stable hemodynamic conditions and predefined fluid management without any vasoactive support or pacing. The prospective observational study was performed in a single university hospital setting.ResultsAssessment of 3D‐RV FWS was feasible in 95% of patients. No included patient experienced any serious perioperative complication. In our group of patients, median values with interquartile range (IQR) for 3D‐RV FWS and 3D‐RV EF were ‒25.2 (IQR ‒29.9 to ‒21.8) and 46.3% (IQR 41.0%‒50.1%), respectively. RV FAC, RV S´, and TAPSE accounted for 39.7% (IQR 34.5%‒44.4%), 14.8 cm/s (IQR 11.8‒19.0 cm/s), and 22 mm (IQR 20‒25 mm). The normal range (2.5% to 97.5% percentile) for 3D‐RV FWS was ‒37.1 to ‒12.8. There was no relevant correlation of 3D‐RV FWS to postoperative outcome in this group of CABG patients.ConclusionWe present distribution values for intraoperative 3D‐RV FWS and conventional parameters of RV function assessment in a healthy on‐pump CABG patient population without serious perioperative complications. We observed no correlations of these parameters with any of the outcome parameters considered. Therefore, we consider these values to be intraoperative TEE‐assessed normal values, which can be expected in on‐pump CABG patients.
A qualitative analysis of adolescent motherhood within the broader family context in Peru
Authors: Levey Elizabeth J. , Morfín Rodriguez Alejandra E. , Chang Andrew R. , Rondon Marta B. , Jimenez Sanchez Maria Luisa , Harrison Alexandra M. , Gelaye Bizu , Becker Anne E. 
Published: May 2023

AbstractObjectiveThe purpose of this study was to characterize the impact of adolescent pregnancy on families and describe the needs of adolescent mothers and their infants in order to assess the need for intervention and identify potential intervention targets.BackgroundAdolescent mothers and their offspring face an increased risk of mental health problems. Adolescent mothers and their families also face significant resource constraints; 95% live in low‐ and middle‐income countries (LMICs). Cost‐effective interventions are needed to improve outcomes for this vulnerable group.MethodThis qualitative study conducted in Lima, Peru, consisted of four clinician focus groups and 18 in‐depth interviews with adolescent mothers and their family members. Data were coded thematically, and direct content analysis was employed.ResultsThe study identified the following issues facing adolescent parents: the transition to parenthood, the need for family support, difficulty accessing support, the difficulty for family members of providing support, and ideas about responsibility and adolescent autonomy.ConclusionOverall, these findings demonstrate the need for interventions that engage families and address barriers to accessing support, including relationship conflict and differing beliefs about responsibility and autonomy.ImplicationsInterventions are needed for adolescent mothers in LMICs that mobilize family support. Clinicians who care for these patients need to be aware of the family context and the resources available where they practice.
Using values in cognitive and behavioral therapy: A bridge back to philosophy
Authors: Martin Sylvia 
Published: May 2023

AbstractAncient therapeutic practices have influenced the development of cognitive behavioral therapy (CBT) theories such as Albert Ellis's rational emotive behavior therapy and Aaron Beck's cognitive therapy. By drawing inspiration from Socratic questioning, the importance of philosophy in evidence‐based practices in human mental health can be acknowledged. Stoicism has also informed CBT, notably its emphasis on establishing psychological distance from emotions. Cognition and emotion are two aspects of mental processes, and irrational demands are processed through rational deliberation. Using mental imaging techniques and acceptance strategies (to accept oneself and the world as imperfect), avoiding catastrophic interpretations and acknowledging emotions are also included among such practices.MethodsWe will explore the use of values across CBT, acceptance and commitment therapy (ACT), and radically open dialectical behavioral therapy (RO DBT) to clarify their use of values.ResultsIn this framework, values are conceptualized as life‐orienting principles and are now widely used across CBTs, such as acceptance and commitment therapy and radically open dialectical behavioral therapy. In recent years, the development of CBT has involved a renewed relationship with philosophy through the use of values, interest in dialectics and development of self‐questioning practices reminiscent of classical Socratic principles. This movement from applied clinical psychology toward philosophical skills has also encouraged the recent emergence of philosophical health considerations. The opposition between psychological and philosophical health can be questioned, and the fundamental issue of philosophical skills implemented in psychiatric treatment (and not solely as practices of enhancement for the sane) needs to be considered.
Multi‐omics profiling of primary hepatic stellate cells from advanced liver fibrosis patients reveals distinctive molecular signatures
Authors: Dong Yutong , Liu Yuwei , Liu Xu , Ma Heming , Liu Yahui , Lv Guoyue , Niu Junqi 
Published: May 2023

AbstractBackground and AimHepatic fibrosis is a common pathogenic outcome of almost all chronic liver diseases and a growing public health problem globally. However, the key genes or proteins driving liver fibrosis and cirrhosis are not well understood. We aimed to identify novel hepatic fibrosis genes of human primary hepatic stellate cells (HSCs).MethodsHuman primary HSCs were isolated from surgically resected advanced fibrosis liver tissues (n = 6) and surgical resection of normal liver tissue around hemangioma (n = 5). Differences in the expression levels of mRNA and proteins from HSCs in advanced fibrosis group and the control group were analyzed using RNA sequencing and mass spectrometry as transcriptomic and proteomic approaches. The obtained biomarkers were further validated through real‐time quantitative polymerase chain reaction (RT‐qPCR), immunofluorescence, and Western blot.ResultsA total of 2156 transcripts and 711 proteins were found to be differently expressed between the advanced fibrosis group and the control group patients. The Venn diagram shows that a total of 96 upregulated molecules are overlapped in both the transcriptomic and proteomic datasets. Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes analysis indicated that those overlapped genes were mainly involved in wound healing, cell adhesion regulation, and actin binding, which reflects the major biological conversions in liver cirrhosis process. Pyruvate kinase M2 and EH domain‐containing 2 were identified as potential new markers for advanced liver cirrhosis, which have been validated in primary human HSCs and in vitro cellular hepatic fibrosis model Lieming Xu‐2 (LX‐2) cells.ConclusionsOur results revealed the major transcriptomic and proteomic changes during liver cirrhosis process and identified new biomarkers and potential therapeutic targets for advanced liver fibrosis.
Reusing Natural Experiments
Authors: HEATH DAVIDSON , RINGGENBERG MATTHEW C. , SAMADI MEHRDAD , WERNER INGRID M. 
Published: May 2023

ABSTRACTAfter a natural experiment is first used, other researchers often reuse the setting, examining different outcome variables. We use simulations based on real data to illustrate the multiple hypothesis testing problem that arises when researchers reuse natural experiments. We then provide guidance for future inference based on popular empirical settings including difference‐in‐differences, instrumental variables, and regression discontinuity designs. When we apply our guidance to two extensively studied natural experiments, business combination laws and the Regulation SHO pilot, we find that many results that were statistically significant using single hypothesis testing do not survive corrections for multiple hypothesis testing.
Association of intra‐shift nap duration with heart rate variability in medical night shift workers
Authors: Deng Saiyue , Wang Quan , Fan Jingjing , Lu Jiajia , Liu Wenhua , Wang Wei , Yang Yuan , Ding Fengfei , Mei Junhua , Ba Li 
Published: May 2023

SummaryNapping during night shifts effectively reduces disease risk and improves work performance, but few studies have investigated the association between napping and physiological changes, particularly in off‐duty daily lives. Changes in the autonomic nervous system precede diseases like cardiovascular disease, diabetes, and obesity. Heart rate variability is a good indicator of autonomic nervous system. This study aimed to investigate the link between night shift nap durations and heart rate variability indices in the daily lives of medical workers. As indicators of chronic and long‐term alterations, the circadian patterns of heart rate variability indices were evaluated. We recruited 146 medical workers with regular night shifts and divided them into four groups based on their self‐reported nap durations. Heart rate variability circadian parameters (midline‐estimating statistic of rhythm, amplitude, and acrophase) were obtained by obtaining 24‐h electrocardiogram on a day without night shifts, plotting the data of the heart rate variability indices as a function of time, and fitting them into periodic cosine curves. Using clinical scales, depression, anxiety, stress, fatigue, and sleepiness were assessed. Linear regression analysis revealed a positive relationship between 61–120‐min naps and 24‐h, daytime, and night‐time heart rate variability indices, and the parasympathetic activity oscillation amplitude (indexed by high‐frequency power, the square root of the mean of the sum of squares of differences between adjacent normal intervals, standard deviation of short‐term R‐R‐interval variability) within one circadian cycle. This study indicated that napping for 61–120 min during night shifts could benefit medical workers’ health, providing physiological evidence to promote nap management.
External validity of the reduced Morningness–Eveningness Questionnaire for Children and Adolescents: an actigraphic study
Authors: Tonetti Lorenzo , Andreose Alice , Bacaro Valeria , Giovagnoli Sara , Grimaldi Martina , Natale Vincenzo , Crocetti Elisabetta 
Published: May 2023

SummaryThe aim of this study was to examine the external validity of the reduced Morningness–Eveningness Questionnaires for Children and Adolescents, using circadian motor activity, assessed through actigraphy, as an external criterion. Overall, 458 participants (269 females), with a mean (standard deviation) age of 15.75 (1.16) years, took part in this study. Each adolescent was requested to wear the actigraph Micro Motionlogger Watch actigraph (Ambulatory Monitoring, Inc., Ardlsey, NY, USA) around the non‐dominant wrist for 1 week. At the end of the actigraphic recording, participants completed the reduced Morningness–Eveningness Questionnaires for Children and Adolescents. We extracted the motor activity counts, minute‐by‐minute over the 24 h, to depict the 24‐h motor activity pattern, and we adopted the statistical framework of functional linear modelling to examine its changes according to chronotype. According to the reduced Morningness–Eveningness Questionnaires for Children and Adolescents cut‐off scores, 13.97% of participants (n = 64) belonged to the evening‐types category, 9.39% (n = 43) to morning‐types, while the remaining (76.64%, n = 351) to the intermediate‐types category. Evening types moved significantly more than the intermediate and morning types from around 10:00 p.m. to 2:00 a.m., while the opposite pattern of results was observed around 4:00 a.m. The results highlighted a significant difference in the 24‐h motor activity pattern between chronotypes, in line with the expectations based on their well‐known behaviour. Therefore, this study shows that the external validity of the reduced Morningness–Eveningness Questionnaire for Children and Adolescents, established by considering motor activity (recorded through actigraphy) as an external criterion, is satisfactory.
Eggonomics: Vitrification and bioeconomies of egg donation in the United States and Spain
Authors: Tober Diane , Pavone Vincenzo , Lafuente‐Funes Sara , Konvalinka Nancy 
Published: May 2023

AbstractRegulations governing assisted reproduction control the degree to which gamete donation is legal and how people providing genetic material are selected and compensated. The United States and Spain are both global leaders in fertility treatment with donor oocytes. Yet both countries take different approaches to how egg donation is regulated. The US model reveals a hierarchically organized form of gendered eugenics. In Spain, the eugenic aspects of donor selection are more subtle. Drawing upon fieldwork in the United States and Spain, this article examines (1) how compensated egg donation operates under two regulatory settings, (2) the implications for egg donors as providers of bioproducts, and (3) how advances in oocyte vitrification enhances the commodity quality of human eggs. By comparing these two reproductive bioeconomies we gain insight into how different cultural, medical, and ethical frameworks intersect with egg donor embodied experiences.