bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of treatment dosage of whole‐body cryotherapy upon post‐match recovery of endocrine and biochemical markers in elite rugby league players: An experimental study
Authors: Naylor Adam S. , Edwards Ben J. , Robertson Colin M. 
Published: April 2023

AbstractBackground and AimsThe use of whole‐body cryotherapy (WBC) for athletic recovery is becoming increasingly popular despite the lack of evidence supporting the dosage parameters in its implementation. The aim of the current study was to investigate the dose–response effects of WBC following match‐play in elite rugby league players.MethodsWe observed endocrine (salivary cortisol and testosterone) and biochemical (creatine kinase) responses following three separate post‐match recovery periods in elite rugby league players. Comparisons were made between a single exposure (3 min at −120°C to ‐−135°C) of WBC to two consecutive exposures (2 × 3 min), to a control (no exposure) during the recovery trials. Recovery characteristics were measured 36 h prematch, immediately postmatch, and 60 h postmatch.ResultsCortisol concentrations remained unchanged in its pattern of response during the postmatch recovery periods across all WBC doses. Testosterone concentrations increased significantly (p < 0.0005) at 60 h, in the WBC2 trial. The Testosterone:Cortisol ratio increased significantly (p < 0.0005) at 60 h in the WBC2 trial, while during the WBC0 trial it did not recover to baseline levels. No significant effect on creatine kinase concentration was observed, although a statistical trend was shown in WBC2 for improved reduction of this marker at 60 h.ConclusionsThese findings suggest that two, consecutive exposures to WBC immediately following fatiguing rugby league competition appear to stimulate an increase to the anabolic endocrine profile of participants by 60 h post‐match, and may reduce the CK concentration. Coaches and athletes should consider the treatment dosage of WBC when used to optimize the desired response following a high‐stress environment.
Unintended lower‐segment hysterotomy extension at cesarean delivery and the risk for uterine rupture during a subsequent trial of labor
Authors: Peled Tzuria , Ashwal Eran , Rotem Reut , Sela Hen Y. , Grisaru‐Granovsky Sorina , Rottenstreich Misgav 
Published: April 2023

AbstractObjectiveTo evaluate the association between unintended uterine extension in cesarean delivery and uterine scar disruption (rupture or dehiscence) at the subsequent trial of labor after cesarean delivery (TOLAC).MethodsThis is a multicenter retrospective cohort study (2005–2021). Parturients with a singleton pregnancy who had unintended lower‐segment uterine extension during the primary cesarean delivery (excluding T and J vertical extensions) were compared with patients who did not have an unintended uterine extension. We assessed the subsequent uterine scar disruption rate following the subsequent TOLAC and the rate of adverse maternal outcome.ResultsDuring the study period, 7199 patients underwent a trial of labor and were eligible for the study, of whom 1245 (17.3%) had a previous unintended uterine extension and 5954 (82.7%) did not. In univariate analysis, previous unintended uterine extension during the primary cesarean delivery was not significantly associated with uterine scar rupture in the following subsequent TOLAC. Nevertheless, it was associated with uterine scar dehiscence, higher rates of TOLAC failure, and a composite adverse maternal outcome. In multivariate analyses, only the association between previous unintended uterine extension and higher rates of TOLAC failure was confirmed.ConclusionA history of unintended lower‐segment uterine extension is not associated with an increased risk for uterine scar disruption following subsequent TOLAC.
Efficient removal of anionic dye by protonated APTES modified hydrochar: The effect of cold‐activation
Authors: Alp Arici Tuğba 
Published: April 2023

AbstractThe study focused on determining the effect of acidic and basic cold activation on hydrochar (HC) for the removal of methyl orange (MO). HC was prepared by hawthorn seeds (HS) under hydrothermal carbonization. HC was cold‐activated with HCl and NaOH, respectively, and they were grafted with aminopropyltriethoxysilane (APTES) and protonated to obtain AHC‐N+ (acid‐activated and modified HC) and BHC‐N+ (base‐activated and modified HC) to determine the effect of acidic and basic activation. They were characterized by elemental analysis, IR, thermal analysis, zeta potential, N2 adsorption–desorption measurements, and SEM–EDX analysis. The prepared adsorbents displayed MO adsorption due to abundant protonated amine groups. BHC‐N+ showed higher MO adsorption than AHC‐N+. The result showed that more protonated APTES groups grafted on the surface of HC via NaOH activation. The obtained data had a good fitting with the Langmuir isotherm and pseudo‐second‐order kinetic. The maximum adsorption capacity of BHC‐N+ was 250.38 mg g−1. The adsorption mechanism could be attributed to the electrostatic interactions between MO and protonated amine groups of APTES and hydrogen bonding.
A comparison between auditory hallucinations, interpretation of voices, and formal thought disorder in dissociative identity disorder and schizophrenia spectrum disorders
Authors: Dorahy Martin J. , Nesbit Amy , Palmer Rachael , Wiltshire Bailey , Cording Jacinta R. , Hanna Donncha , Seager Lenaire , Middleton Warwick 
Published: April 2023

AbstractObjectivesDissociative identity disorder (DID) and schizophrenia‐spectrum disorders (SSD) share some overlapping phenomenological features making accurate diagnosis more difficult. Childhood abuse and depersonalization have been associated with psychotic symptoms across psychological disorders but their relationship to psychotic phenomenology remains understudied.MethodThe present study used quantitative measures to examine (1) similarities and differences in phenomenological voice hearing experiences, interpretations of voices, and thought disorder symptoms in individuals with DID (n = 44) or SSD (n = 45), and (2) whether depersonalization and childhood maltreatment influenced the initial pattern of findings.ResultsDID participants perceived their voices as being more internally located and generated, louder, and uncontrollable than SSD participants. Furthermore, the DID participants endorsed a greater frequency of thought disorder symptoms. Adding the covariates (sex, depersonalization, and child maltreatment) did not change the findings associated with location and origin of voices, and derailment, but there were now no differences in loudness or controllability. However, the schizophrenia sample reported more distress and metaphysical beliefs associated with voices, as well as more thought disorder incoherence and word substitution with the covariates controlled.ConclusionWhile tentative, metaphysical interpretations of voices, incoherent thoughts and word substitution may reflect more psychotic processes.
Patient‐reported outcomes on empagliflozin treatment in glycogen storage disease type Ib: An international questionnaire study
Authors: Grünert Sarah C. , Venema Annieke , LaFreniere Jamas , Schneider Blair , Contreras Enrique , Wortmann Saskia B. , Derks Terry G. J. 
Published: April 2023

AbstractIn patients with glycogen storage disease type Ib (GSD Ib), quality of life is severely hampered by neutropenia and neutropenia‐associated symptoms. SGLT2 inhibitors are a new treatment option and have shown improved medical outcomes in more than 120 patients so far. The aim of this international questionnaire study was to assess patient‐reported outcomes of this new treatment in GSD Ib patients. Patients and caregivers of pediatric patients were invited to complete a web‐based questionnaire. This was designed to evaluate treatment effects of the SGLT2 inhibitor empagliflozin on clinical symptoms and important aspects of daily life including physical performance, sleep, social and work life, traveling, socioeconomic aspects, and quality of life. The questionnaire was completed by 73 respondents from 17 different countries. The mean duration of treatment was 15 months, the cumulative treatment time was 94.8 years. More than 80% of patients reported an improved quality of life. The number of hospitalizations was reduced (66% of patients), as well as the number of days absent from school or work. Granulocyte colony‐stimulating factor (G‐CSF) treatment could be stopped in 49% of patients and reduced in another 42%. Clear improvement of neutropenia and all neutropenia‐associated symptoms was reported by the majority of patients. Additionally, patients or caregivers reported positive effects on appetite (63%), level of activity (75%), overall well‐being (96%), and sleep (63%). Empagliflozin positively impacts many aspects of daily life including work and social life and thereby significantly improves quality of life of patients and caregivers.
Evaluation of host cellular responses to Epstein–Barr virus (EBV) in adult lung transplant patients with EBV‐associated diseases
Authors: Zaffiri Lorenzo , Messinger Joshua E. , Bush Erika J. , Staats Janet S. , Patel Prekshaben , Palmer Scott M. , Weinhold Kent J. , Snyder Laurie D. , Luftig Micah A. 
Published: April 2023

AbstractEpstein–Barr virus (EBV) reactivation is commonly observed in lung transplant recipients (LTRs). However, cellular immune responses to EBV in adult LTRs have not been well described. We aimed to study CD4/CD8 ratio, EBV‐specific T cells polyfunctional responses and phenotypic changes in natural killer (NK) cells in adult LTRs presenting with EBV‐associated diseases. The CD4/CD8 ratio was significantly decreased in LTRs with EBV DNAemia compared with LTRs without EBV DNAemia and healthy controls (HCs). Stimulation with EBV lytic antigen BZLF1 peptide pools induced significant individual and polyfunctional responses from CD8+CD69+ T cells. Frequencies of CD8+CD69+ T cells expressing CD107a were significantly higher in LTRs without EBV DNAemia than in LTRs with DNAemia. Frequencies of CD8+CD69+ T cells concurrently expressing CD107a, IFN‐γ, and TNF‐α were significantly greater in LTRs with and without EBV DNAemia than in HCs. Finally, BZLF1 induced significantly higher frequencies of CD8+CD69+ T cells expressing CD107a and IFN‐γ in LTRs without EBV DNAemia when compared with EBNA3B. Frequency of more differentiated CD56dimCD16pos NK cells was significantly decreased in LTRs with EBV DNAemia and PTLD compared with HCs. In conclusion, we noted the presence of significant changes in circulating cellular immune responses to EBV in adult LTRs.
Diverging trends in US summer dewpoint since 1948
Authors: Scheff Jacob , Burroughs James Cody 
Published: April 2023

AbstractIncreases in summer humidity are a basic threat to human survival, because the body cannot shed heat by sweating if absolute humidity is too high. However, climate change trends and patterns of extreme humidity have been much less studied than those of extreme temperature. Here, using station data, we provide an up‐to‐date and comprehensive assessment of the patterns and 1948–2020 trends of summertime dewpoint () in the contiguous United States, for multiple percentiles of its distribution ranging from median to extreme. We find that summer‐median is maximized in the Southeast and along the coasts, while extreme summer is counterintuitively higher in the Midwest than in much of the Southeast, and is higher in Western agricultural valleys than on the Pacific coast. In contrast, 1948–2020 trends in summer are broadly consistent across percentiles, but quite divergent regionally. Namely, median and extreme have strongly increased in Florida, South Texas, parts of California and from the Northeast to the Northern Plains, but have declined in the Intermountain West and changed little elsewhere, often despite clear summertime warming. These regional non‐increases contradict basic theory, but agree with several recent studies. In addition, median is increasing more systematically than extreme in several parts of the eastern United States. Future work will seek to uncover the reasons for all of these divergences and to better understand the fate of summer humidity worldwide.
Synchronous variation of dissolved organic carbon in Adirondack lakes at multiple timescales
Authors: Walter Jonathan A. , Coombs Nat J. , Pace Michael L. 
Published: April 2023

AbstractDissolved organic carbon (DOC) is a key component of aquatic ecosystems with complex effects on ecosystem function. While long‐term increases in DOC termed “brownification” have received considerable attention, directional trends typically account for a minority of variance. DOC concentrations also fluctuate on seasonal to multiannual timescales, but the causes of such variations are less understood. We used a wavelet‐based approach to study timescale‐specific, spatially synchronous fluctuations in DOC across 49 lakes in the Adirondacks, New York, USA. DOC varies synchronously among lakes at within‐season, annual, and interannual timescales, but relationships with external drivers and internal processes indicated by lake chemistry differed across timescales. External drivers explained 78% of spatial DOC synchrony at the annual time scale. Beyond positive trends related to regional recovery from acidification, variability in DOC is a consequence of fluctuations at several timescales that are common among Adirondack lakes in precipitation, solar radiation, and internal chemical concentrations.
Toward a common standard for data and specimen provenance in life sciences
Authors: Wittner Rudolf , Holub Petr , Mascia Cecilia , Frexia Francesca , Müller Heimo , Plass Markus , Allocca Clare , Betsou Fay , Burdett Tony , Cancio Ibon , Chapman Adriane , Chapman Martin , Courtot Mélanie , Curcin Vasa , Eder Johann , Elliot Mark , Exter Katrina , Goble Carole , Golebiewski Martin , Kisler Bron , Kremer Andreas , Leo Simone , Lin‐Gibson Sheng , Marsano Anna , Mattavelli Marco , Moore Josh , Nakae Hiroki , Perseil Isabelle , Salman Ayat , Sluka James , Soiland‐Reyes Stian , Strambio‐De‐Castillia Caterina , Sussman Michael , Swedlow Jason R. , Zatloukal Kurt , Geiger Jörg 
Published: April 2023

AbstractOpen and practical exchange, dissemination, and reuse of specimens and data have become a fundamental requirement for life sciences research. The quality of the data obtained and thus the findings and knowledge derived is thus significantly influenced by the quality of the samples, the experimental methods, and the data analysis. Therefore, a comprehensive and precise documentation of the pre‐analytical conditions, the analytical procedures, and the data processing are essential to be able to assess the validity of the research results. With the increasing importance of the exchange, reuse, and sharing of data and samples, procedures are required that enable cross‐organizational documentation, traceability, and non‐repudiation. At present, this information on the provenance of samples and data is mostly either sparse, incomplete, or incoherent. Since there is no uniform framework, this information is usually only provided within the organization and not interoperably. At the same time, the collection and sharing of biological and environmental specimens increasingly require definition and documentation of benefit sharing and compliance to regulatory requirements rather than consideration of pure scientific needs. In this publication, we present an ongoing standardization effort to provide trustworthy machine‐actionable documentation of the data lineage and specimens. We would like to invite experts from the biotechnology and biomedical fields to further contribute to the standard.
Striking a match between FHIR‐based patient data and FHIR‐based eligibility criteria
Authors: Alper Brian S. , Dehnbostel Joanne , Shahin Khalid , Ojha Neeraj , Khanna Gopal , Tignanelli Christopher J. 
Published: April 2023

AbstractInputs and OutputsThe Strike‐a‐Match Function, written in JavaScript version ES6+, accepts the input of two datasets (one dataset defining eligibility criteria for research studies or clinical decision support, and one dataset defining characteristics for an individual patient). It returns an output signaling whether the patient characteristics are a match for the eligibility criteria.PurposeUltimately, such a system will play a “matchmaker” role in facilitating point‐of‐care recognition of patient‐specific clinical decision support.SpecificationsThe eligibility criteria are defined in HL7 FHIR (version R5) EvidenceVariable Resource JSON structure. The patient characteristics are provided in an FHIR Bundle Resource JSON including one Patient Resource and one or more Observation and Condition Resources which could be obtained from the patient's electronic health record.ApplicationThe Strike‐a‐Match Function determines whether or not the patient is a match to the eligibility criteria and an Eligibility Criteria Matching Software Demonstration interface provides a human‐readable display of matching results by criteria for the clinician or patient to consider. This is the first software application, serving as proof of principle, that compares patient characteristics and eligibility criteria with all data exchanged using HL7 FHIR JSON. An Eligibility Criteria Matching Software Library at https://fevir.net/110192 provides a method for sharing functions using the same information model.
Enhanced Anti‐Corrosion Performance of Carbon Steels via CeO2@BNNSs/Epoxy Resin Composite Coatings
Authors: Duan Hongliang , Ji Jiawei , Cao Chaochao , Bai Wenjuan , Song Zirui , Xue Yanming , Tang Chengchun 
Published: April 2023

AbstractDue to its excellent physical barrier behavior and high physicochemical stability, hexagonal boron nitride (h‐BN) can improve the anti‐corrosion capacity of a favorite protective coating onto metals. However, the poor dispersion of h‐BN filler in the formation of polymer composites does not promote its further wide application in the field of corrosion protection. In this work, a new CeO2@BNNSs filler is highly dispersed into aqueous epoxy (EP) to make nice coatings onto steels. As a result, after immersing them into an NaCl solution of 3.5 wt% for 20 days, the as‐prepared CeO2@BNNSs/EP composite coatings can keep an impedance modulus (|Z|f = 0.01 Hz) value of 9.61 × 107 Ω cm2, which is larger than those of the blank EP and the EP filled with the h‐BN and BNNSs fillers. In addition, compared to the EP, h‐BN/EP, and BNNSs/EP coatings, the higher corrosion potential, the properties of larger polarization resistance, and lower corrosion current density for the CeO2@BNNSs/EP coatings indicate CeO2@BNNSs/EP's excellent protective ability to the steel from corrosion. It is believed that this kind of CeO2@BNNSs/EP composite materials and its coatings would be highly promising for application in future advanced anti‐corrosion environments and devices.
Hardy spaces associated with ball quasi‐Banach function spaces on spaces of homogeneous type: Characterizations of maximal functions, decompositions, and dual spaces
Authors: Yan Xianjie , He Ziyi , Yang Dachun , Yuan Wen 
Published: April 2023

AbstractLet be a space of homogeneous type in the sense of Coifman and Weiss, and let be a ball quasi‐Banach function space on , which supports both a Fefferman–Stein vector‐valued maximal inequality and the boundedness of the powered Hardy–Littlewood maximal operator on its associate space. The authors first introduce the Hardy space , associated with , via the grand maximal function and then establish its various real‐variable characterizations, respectively, in terms of radial or nontangential maximal functions, atoms or finite atoms, and molecules. As an application, the authors give the dual space of , which proves to be a ball Campanato‐type function space associated with . All these results have a wide range of generality and, particularly, even when they are applied to variable Hardy spaces, the obtained results are also new. The major novelties of this paper exist in that, to escape both the reverse doubling condition of μ and the triangle inequality of ρ, the authors cleverly construct admissible sequences of balls and fully use the geometrical properties of expressed by dyadic reference points or dyadic cubes and, to overcome the difficulty caused by the lack of the good dense subset of , the authors further prove that can be embedded into the weighted Lebesgue space with certain special weight and then can fully use the known results of the weighted Lebesgue space.
Effect of Surfactant Selectivity on Shape and Inner Morphology of Triblock Terpolymer Microparticles
Authors: Trömer Manuel , Zirdehi Elias M. , Nikoubashman Arash , Gröschel André H. 
Published: April 2023

AbstractThe confined assembly of block copolymers (BCPs) has become a useful tool to prepare microparticles with controlled anisotropy and inner structure. While a solid understanding of the behavior of AB diblock copolymers exists, knowledge on the parameters affecting ABC triblock terpolymer assembly is much more limited. In this work, the effect of block‐selective surfactants, sodium‐4‐vinylbenzenesulfonate (VBS) and sodium dodecylsulfate (SDS), is analyzed in the evaporation‐induced confined assembly (EICA) of a polystyrene‐block‐polybutadiene‐block‐poly(methyl methacrylate) triblock terpolymer (SBM). Despite using the same terpolymer and emulsification process, SDS results in ellipsoidal microparticles with axially stacked lamellae, while VBS results in spherical microparticles with concentric lamellae or 3D spiral morphology. This change in morphology upon switching the surfactant is further substantiated by molecular simulations and enhances the understanding of terpolymer microphase separation in confinement.
Contemporary and Looming Applications of Carbon Nanotubes
Authors: Jain Nidhi , Negi Akanksha 
Published: April 2023

AbstractMolding the future with the use of new technology is utmost important for the progress of human race. Nanotechnologies are the emerging field. Carbon nanotubes (CNTs) are the widely known substances used mostly in all types of the application such as catalysts, absorbents for water treatment, photocatalysis. Various methods of synthesis of CNTs are known, but in this paper, as a case study, green process synthesis has been discussed in CNTs. Different six stages in the life cycle of CNTs have been discussed in the paper that relates to different risk factors in the field. Synchronization of science and technology is important for usage of the materials. This paper provides more brief holistic view of the state of the CNTs at various fields. The attention of this study is also on the toxicity, bioaccumulation, and safety concerns as well as the remedial capabilities