bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early oral feeding following intestinal anastomosis surgery in infants: a multicenter real world study
Authors: Lu Changgui , Sun Xinhe , Geng Qiming , Tang Weibing 
Published: July 2023

BackgroundTo prevent postoperative complications, delayed oral feeding (DOF) remains a common model of care following pediatric intestinal anastomosis surgery; however, early oral feeding (EOF) has been shown to be safe and effective in reducing the incidence of complications and fast recovery after pediatric surgery. Unfortunately, the evidence in support of EOF after intestinal anastomosis (IA) in infants is insufficient. Therefore, this study was primarily designed to evaluate the safety and efficacy of EOF. In addition, the current status of EOF application and associated factors that favor or deter EOF implementation were also assessed.MethodsA total of 898 infants were divided into two groups (EOF group, n = 182; DOF group, n = 716), and the clinical characteristics were collected to identify the factors associated with EOF in infants. Complications and recovery were also compared to define the safety and efficacy after balancing the baseline data by propensity score matching (PSM) (EOF group, n = 179; DOF group, n = 319).ResultsThe total EOF rate in infants with IA was 20.3%. Multivariate logistic regression revealed significant differences in the EOF rates based on IA site and weight at the time of surgery (OR = 0.652, 95% CI: 0.542–0.784, p &lt; 0.001) and (OR = 1.188, 95% CI: 1.036–1.362, p = 0.013), respectively. The duration of total parenteral nutrition (TPN), parenteral nutrition (PN), and postoperative hospital stay were significantly shorter in the EOF group than the DOF group [2.0 (1.0, 2.0) d vs. 5.0 (3.0, 6.0) d; 6.0 (5.0, 8.0) d vs. 8.0 (6.0, 11.0) d; 10.0 (7.0, 14.0) d vs. 12.0 (9.0, 15.0) d, all p &lt; 0.001]. The rates of abdominal distension and vomiting in the EOF group were significantly higher than the DOF group (17.9% vs. 7.2%, p &lt; 0.001; 7.8% vs. 2.5%, p = 0.006); however, no differences were found in failure to initial OF, diarrhea, hematochezia, and anastomotic leakage between the two groups (p &gt; 0.05).ConclusionThe overall rate of EOF in infants following IA was low, and the sites of anastomosis and weight at surgery were two factors associated with EOF. Nevertheless, performing EOF in infants after IA was safe and effective, reduced PN usage, shortened the hospital stay, and did not increase the rate of severe complications.Clinical Trial Registration: ClinicalTrails.gov, identifier NCT04464057.
GC-MS chemical profiling, antioxidant, anti-diabetic, and anti-inflammatory activities of ethyl acetate fraction of Spilanthes filicaulis (Schumach. and Thonn.) C.D. Adams leaves: experimental and computational studies
Authors: Ojo Oluwafemi Adeleke , Ogunlakin Akingbolabo Daniel , Gyebi Gideon Ampoma , Ayokunle Damilare IyinKristi , Odugbemi Adeshina Isaiah , Babatunde Dare Ezekiel , Ajayi-Odoko Omolola Adenike , Iyobhebhe Matthew , Ezea Samson Chukwuemeka , Akintayo Christopher Oloruntoba , Ayeleso Ademola , Ojo Adebola Busola , Ojo Omolara Olajumoke 
Published: July 2023

Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-diabetic, and anti-inflammatory activities of the ethyl acetate fraction of Spilanthes filicaulis leaves (EFSFL) via experimental and computational studies.Methods: After inducing oxidative damage with FeSO4, we treated the tissues with different concentrations of EFSFL. An in-vitro analysis of EFSFL was carried out to determine its potential for antioxidant, anti-diabetic, and anti-inflammatory activities. We also measured the levels of CAT, SOD, GSH, and MDA.Results and discussion: EFSFL exhibited anti-inflammatory properties through membrane stabilizing properties (IC50 = 572.79 μg/ml), proteinase inhibition (IC50 = 319.90 μg/ml), and inhibition of protein denaturation (IC50 = 409.88 μg/ml). Furthermore, EFSFL inhibited α-amylase (IC50 = 169.77 μg/ml), α-glucosidase (IC50 = 293.12 μg/ml) and DPP-IV (IC50 = 380.94 μg/ml) activities, respectively. Our results indicated that induction of tissue damage reduced the levels of GSH, SOD, and CAT activities, and increased MDA levels. However, EFSFL treatment restores these levels to near normal. GC-MS profiling shows that EFSFL contains 13 compounds, with piperine being the most abundant. In silico interaction of the phytoconstituents using molecular and ensembled-based docking revealed strong binding tendencies of two hit compounds to DPP IV (alpha-caryophyllene and piperine with a binding affinity of −7.8 and −7.8 Kcal/mol), α-glucosidase (alpha-caryophyllene and piperine with a binding affinity of −9.6 and −8.9 Kcal/mol), and to α-amylase (piperine and Benzocycloheptano[2,3,4-I,j]isoquinoline, 4,5,6,6a-tetrahydro-1,9-dihydroxy-2,10-dimethoxy-5-methyl with a binding affinity of −7.8 and −7.9 Kcal/mol), respectively. These compounds also presented druggable properties with favorable ADMET. Conclusively, the antioxidant, antidiabetic, and anti-inflammatory activities of EFSFL could be due to the presence of secondary metabolites.
УКРАЇНСЬКЕ КОЗАЦТВО У ТВОРЧОСТІ CАМУЕЛЯ ЗІ CКРИПНИ ТВАРДОВСЬКОГО
Authors: Pylypenko Volodymyr 
Published: July 2023

Метою роботи є проаналізувати образ українського козацтва у творах польського поета середини XVII ст. Самуеля Твардовського. Завдання роботи: визначити, якими термінами користувався Твардовський для опису українського козацтва, що ці терміни означали для освічених читачів XVII ст., як змінювалися описи козацтва в творах Твардовського. Актуалізація теми. Українське козацтво лишається однією з популярних тем в українській історіографії. Але окрім досліджень історії власне козацтва, цікаво поглянути на козацтво з іншого боку – зрозуміти, як бачила козаків польська інтелектуальна еліта, які способи вирішення конфліктів вони пропонували. Самуель Твардовський був одним із відомих письменників сер. XVII ст. Його вплив на розвиток польської літератури визнавали вже сучасники. До теми українського козацтва він звернувся досить пізно, тоді, коли вже не було сенсу її ігнорувати. На мою думку, «відсутність» козаків у текстах Твардовського протягом 1630–1640 рp. можна пояснити тим, що поет не хотів зайвий раз злити своїх покровителів і потенційних меценатів. Твором, в якому поет проявив власне ставлення до козаків, до повстання та козацьких ватажків, була поема «Wojna domowa». Головними ознаками козаків у поемі стали: велика кількість, безликість (майже не нотує імена ватажків, окрім Богдана та Тимофія Хмельницьких, М. Кривоноса, І. Богуна), жорстокість, зрадливість. Окремо слід відмітити характеристику Б. Хмельницького як тирана. Висновки. Вокабуляр Самуеля Твардовського мав як досить поширені терміни й поняття для характеристики козаків, так складні поняття класичної політичної теорії. Наприклад, термін тиран, який у поета мав подвійне значення.
Identificação de estudos para a elaboração de um roadmap de processo de gestão ágil de portfólio de projetos para universidades
Authors: De Santana Leandro Tenorio , De Azevedo Marília Macorin 
Published: July 2023

O processo de transformação digital tem impacto na administração pública, conjunto, como universidades públicas, tanto quanto as atividades ativas quanto a administração. Além de quais são as mais importantes, como instituições internacionais ou eventos do plano estratégico de tecnologia da informação e comunicação. Como também, projetos de projetos de eventos e eventos, os quais são os implantes de melorias, novos produtos, serviços e outros. O projeto de pesquisa como um processo que pode ser encontrado em diversos elementos para monitores, controles e projetos de acompanhamento, vinculando uma estratégia com uma execução. Neste sentido, o presente estudo tem como objetivo identificar quais são os estudos que contribuem para a construção de um roteiro processo de gestão do porto de tecnologia da informação e comunicação para uma universidade pública. Os objetivos específicos são: analisar uma evolução das publicações; identificador como redes de colaboração; mapear os principais periódicos; avaliar o impacto dos estudos. Uma metodologia aplicada é uma bibliometria e para o processo de filtragem e seleção de artigos básicos - não há protocolo prisma-p. Os resultados indicam um comentário sobre a mídia de arte publicada nos últimos cinco anos. O Brasil aparece como um dos principais contribuintes para esse tipo de pesquisa e trabalho e valores significativos para os mapeados. Como possível limite de arte, O produto é um produto de peso mais amplo ou mais um tipo de base de processo.Este estudo é parte de um projeto de pesquisa mais ampla e um caso anterior envolvendo uma revisão da literatura e do desenvolver um roteiro de processo.
A Mitochondrion‐Inspired Magnesium–Oxygen Biobattery with High Energy Density In Vivo
Authors: He Er , Ren Junye , Wang Lie , Li Fangyan , Li Luhe , Ye Tingting , Jiao Yiding , Li Dan , Wang Jiacheng , Wang Yuanzhen , Gao Rui , Zhang Ye 
Published: July 2023

AbstractImplantable batteries are urgently needed as a power source to meet the demands of the next generation of biomedical electronic devices. However, existing implantable batteries suffer from unsatisfactory energy density, hindering the miniaturization of these devices. Here, a mitochondrion‐inspired magnesium–oxygen biobattery that achieves both high energy density and biocompatibility in vivo is reported. The resulting biobattery exhibits a recorded energy density of 2517 Wh L–1/1491 Wh kg–1 based on the total volume/mass of the device in vivo, which is ≈2.5 times higher than the current state‐of‐the‐art, and can adapt to different environments for stable discharges. The volume of the magnesium–oxygen biobattery can be as thin as 0.015 mm3 and can be scaled up to 400 times larger without reducing the energy density. Additionally, it shows a stable biobattery/tissue interface, significantly reducing foreign body reactions. This work presents an effective strategy for the development of high‐performance implantable batteries.
Pharmacokinetic and Bioequivalence Evaluation of Two Cefprozil Dispersible Tablets in Healthy Chinese Volunteers
Authors: Xu Lang , Su Jianfen , Muhetaer Halimulati , Zhang Canhua , Huang Chen , Tang Yukuan , Fu Xihua , Liang Zhimin 
Published: July 2023

AbstractThis study aimed to assess the bioequivalence of 2 cefprozil dispersible tablet formulations (250 mg) in healthy Chinese volunteers under fasting and fed conditions and to determine the pharmacokinetics of cefprozil. A randomized, single‐dose, open‐label, 2‐formulation, 2‐period study was conducted. The elimination period for this study was 7 days. Forty‐eight healthy volunteers received 250‐mg cefprozil dispersible tablets in each study period under both test and reference conditions. The test and the reference cefprozil were bioequivalent in healthy Chinese volunteers, and there was no significant food effect in individuals receiving either formulation. No serious adverse event was recorded, and no volunteers withdrew from the study.
Adaptive tuning of uncertain parameters in a numerical weather prediction model based upon data assimilation
Authors: Zängl Günther 
Published: July 2023

AbstractIn numerical weather prediction models, near‐surface quantities like 10‐m wind speed (FF10M) or 2‐m temperature (T2M) tend to exhibit significantly larger forecast errors than the related variables in the free troposphere. Besides representativeness issues of surface stations, this is primarily related to parametrization errors and insufficient knowledge of relevant physical properties of the soil and the surface layer. For instance, the vegetation roughness length is usually derived from land‐cover classifications that may contain errors and reflect only part of the natural variability. This article describes a methodology implemented into Deutscher Wetterdienst's operational numerical weather prediction model ICON in order to improve the estimate of such parameters by using information from the data assimilation system. Building upon the condition that FF10M, T2M, and 2‐m relative humidity are assimilated, time‐filtered assimilation increments are calculated for the respective fields at the lowest model level. These are taken as proxies for the related model biases. For T2M, an additional weighted increment field is computed that indicates the model bias in the diurnal temperature amplitude. Based on these increment fields, several physical parameter fields and a few model tuning parameters are varied around their base values. This adaptive parameter adjustment is used operationally in the global and regional forecasting systems of Deutscher Wetterdienst. The ensuing reduction of the FF10M, T2M, and 2‐m relative humidity errors typically lies on the order of 5% on a hemispheric average but has substantial regional and seasonal variability that depends on the original magnitude of the model error. A weaker but still statistically significant positive impact is seen in the radiosonde verification of wind speed, humidity, and temperature in the lower troposphere, giving confidence that the adaptive tuning indeed reduces model errors rather than pushing the model towards unrepresentative station observations.
Correlation Between Altmetric Scores and Citation Count in 4 High-Impact Plastic Surgery Journals
Authors: Smartz Taylor M , Jabori Sinan K , Djulbegovic Mak B , Watane Arjun , Sayegh Yoseph , Lyons Nicole , Singh Devinder P 
Published: July 2023

Abstract

Background
The Altmetric Attention Score (AAS) aims to determine the impact of research articles throughout the internet and social media outlets. The AAS is a weighted average of the interaction on platforms including Twitter, Facebook, Reddit, and more.

Objectives
The aim of this study was to investigate the relationship between the AAS and traditional bibliometrics across plastic surgery journals.

Methods
Articles, number of citations (NOC), and H-index information in Annals of Plastic Surgery (APS), Plastic and Reconstructive Surgery (PRS), Plastic and Reconstructive Surgery Global Open (PRS GO), and Aesthetic Surgery Journal (ASJ) from 2017, 2018, and 2019 were queried with the Scopus Online Tool. AAS metrics were collected with the Altmetric Score Calculator Bookmarklet. Descriptive statistics, Spearman rank-correlation analyses, and analyses of variance were performed to measure associations between NOC and AAS.

Results
A total of 3612 articles were analyzed. NOC was weakly correlated with AAS in APS, PRS GO, and ASJ, and moderately correlated with AAS in PRS. NOC was weakly correlated with Twitter mentions in APS, PRS GO, and ASJ, and moderately correlated in PRS. NOC was weakly correlated with news outlet reporting. The H-index of the first author showed more significant correlations with the AAS than the H-index of the last author.

Conclusions
NOC and H-index of the first author correlated with AAS in the plastic surgery literature, suggesting AAS may be a useful adjunct to traditional bibliometrics when evaluating the impact and reach of peer-reviewed articles.
Differential effects of plant and animal fats on obesity‐induced dyslipidemia and atherosclerosis in Ldlr−/−.Leiden mice
Authors: Morrison Martine C. , Egelandsdal Bjørg , Harvei Silje , Rocha Sérgio D. C. , Pieterman Elsbet J. , Kleemann Robert , Carlsen Harald 
Published: July 2023

AbstractCardiovascular disease (CVD) is closely associated with obesity through risk factors such as dyslipidemia and chronic low‐grade inflammation, which may be affected by diet. Dietary fats have been extensively studied in relation to CVD risk, however these studies have not always yielded consistent results, most likely due to lack in control of experimental conditions and confounding factors. Here we studied the effects of different plant and animal fats on dyslipidemia, inflammation, and atherosclerosis. Ldlr−/−.Leiden mice were fed isocaloric energy‐dense diets with translational macronutrient composition for 28 weeks. The diets were identical apart from the type of fat they contained: either (1) a mixture of olive and rapeseed oil, (2) sunflower oil, (3) pork fat, (4) beef fat, or (5) milk fat. The fatty acid composition of the diets was determined and effects on circulating lipid and inflammatory risk factors and atherosclerosis were examined, complemented by adipose tissue histology and liver transcriptomics. While visceral fat mass, adipocyte size, and adipose tissue inflammation were not differentially affected by the diets, atherosclerotic lesion load and severity was more pronounced with increasing dietary saturated fatty acid content and decreasing monounsaturated and polyunsaturated fatty acid content, and hence most pronounced with beef and milk fat. These differential effects were accompanied by increases in pro‐atherogenic plasma lipids/lipoproteins (e.g., triglycerides, apolipoprotein B), activation of pro‐atherogenic cytokine/chemokine signaling pathways in liver, and with circulating pro‐atherogenic mediators of inflammation altogether providing a rationale for the differential effects of plant and animal fats.
Risk factors of infection among close contacts of COVID-19: A systematic review and meta-analysis
Authors: Gao Chun , Jiang Jing-Jing , Mao Jun-Feng , Yu Xiao-Hui , Zheng Xiao-Feng , Zhang Jiu-Cong 
Published: July 2023

Background:
Coronavirus disease 2019 (COVID-19) was first detected in December 2019, and declared as a pandemic by the World Health Organization (WHO) on March 11, 2020. The current management of COVID-19 is based generally on supportive therapy and treatment to prevent respiratory failure.

Methods:
PubMed, Web of Science, Embase, CNKI, and other databases were searched by computer, and relevant literature published from December 2019 to November 2022 on the influencing factors of infection in close contacts with novel coronavirus pneumonia was collected. Meta-analysis was carried out after literature screening, quality assessment, and data extraction.

Results:
A total of 425 articles were retrieved and 11 were included. Meta-analysis showed that there were 6 risk factors, and the combined OR value and 95% CI of each influencing factor were 5.23 (3.20, 8.57) for family members, 1.63 (0.56, 4.77) for regular contact, 2.14 (0.62, 7.32) for the elderly, 0.58 (0.001569.89) for cohabitation, 1.97 (1.02, 3.82) for women and 0.75 (0.01, 54.07) for others. The Deeks’ funnel diagram indicates that there is no potential publication bias among the included studies.

Conclusion:
Family members and gender differences are the risk factors of infection among close contacts, and it cannot be proved that there are differences in infection among frequent contact, advanced age, and living together.
Neuroendocrine tumors in a patient with multiple endocrine neoplasia type 1 syndrome: A case report and review of the literature
Authors: Deng Jian , Liao Xinyi , Cao Hong 
Published: July 2023

Rationale:
Hyperparathyroidism is caused by parathyroid tumors combined with gastroenteropancreatic tumors and pituitary tumors, which is common in patients with multiple endocrine neoplasia 1 syndrome (MEN-1). As its main pathogenic factor involves genetic mutations, it can cause a variety of different clinical symptoms. However, cases with negative genetic testing results and multiple nonfunctional malignant neuroendocrine tumors (NETs) with metastasis are relatively rare.

Patient concerns:
A 33-year-old man was admitted to the hospital for hyperparathyroidism. Imaging examination revealed multiple nodules in the parathyroid gland, pancreas, thymus, and adrenal gland, and multiple metastases to the lung, liver, thoracolumbar, as well as mediastinal lymph nodes.

Diagnoses:
After multidisciplinary consultation, this patient was diagnosed with MEN-1 syndrome with various original tumors and multiple systemic metastases.

Interventions:
The patient underwent parathyroid tumor resection and metastasis biopsy.

Outcomes:
The patient received denosumab and sorafenib treatment.

Lessons:
As an autosomal dominant hereditary disease, MEN-1 patients present with parathyroid hyperplasia, pancreatic and intestinal tumors, pituitary tumors, and so on, which are caused by genetic mutations. These patients would have hyperparathyroidism, hypoglycemia, gastric ulcer, and gastrointestinal diseases. However, some patients with MEN-1 syndrome cannot be diagnosed by genetic testing and simultaneously present with multiple nonfunctional NETs with systemic metastasis. This increases the difficulty of diagnosis and the subsequent treatment.
Comparison between different treatment regimens of vascular targeting drug to malignant pleural effusion in patients with lung cancer: A Bayesian network meta-analysis
Authors: Huang Peng , Guo Zhi-Kai , Xue Zhan-Tu 
Published: July 2023

Background:
The presence of malignant pleural effusion in lung cancer patients often suggests a poor prognosis. We plan to investigate which regimen of vascular targeting drug is preferable to control the malignant pleural effusion in such patients.

Methods:
Two investigators dependently searched and screened for randomized controlled trials in PubMed, Embase, Web of Science and China National Knowledge Infrastructure from the database inception to August 2022. R software was applied to build a network model in Bayesian method. Objective response rate of malignant pleural effusion is the primary outcome measure. Besides, the incidence of 3 adverse events were compared, including gastrointestinal reaction, leukopenia and hypertension. Due to the disconnection of network, we analysis and discuss the short-term treatment (3–4 weeks) and long-term treatment (6–12 weeks) respectively.

Results:
31 studies with 2093 patients were identified. Four targeting drugs contain bevacizumab (Bev), anlotinib, apatinib and Endostar. Two administration routes include intracavity perfusion (icp) and intravenous injection. Based on the current evidence, for short-term treatments, compared with single-agent chemotherapy (CT), Bev_icp + CT, anlotinib + CT, Bev_icp and anlotinib + endorstar_icp present better objective response, and no statistical significance was found in objective response between Bev_icp + CT, anlotinib + CT and Bev_icp. For long-term treatments, compared with doublet or triplet chemotherapy (2CT or 3CT), Bev_icp + 2CT, apatinib + 2CT, Bev_icp + 3CT, and Bev_intravenous injection + 2CT are more effective option, but no statistical significance was found in objective response between the 4 combination regimens with chemotherapy.

Conclusion:
Our findings suggest that no statistical significance between above vascular targeting regimens. Pathological type of lung cancer may affect the effect of bevacizumab intracavity infusion plus chemotherapy. The influence of different administration routes of vascular targeting drugs on efficacy remains to be investigated. There are some concerns with the quality of the studies, and some limitations should be considered when interpreting these results, which includes limited geographical region and sample size of studies. Despite these limitations, this study may inform vascular targeting therapy choice in such a patient population.