bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, preparation, and reliability testing of low‐cost 3D‐printed ABS scanner
Authors: Li Chen , Chen Shuai , Xu Shihao 
Published: July 2023

AbstractScanning mirrors can deflect, reflect, and pattern the laser beam. Traditional laser galvanometers rely on deflection motors and mirrors, which are bulky and costly. Micro‐electro‐mechanical systems (MEMS) micromirrors have small size and high integration, but they require long preparation cycles and sophisticated equipment and expensive materials. Polymer scanners prepared by 3D printing technology have the advantages of low cost and rapid preparation, but their reliability needs further study. In this study, a single‐axis electromagnetic scanner was proposed and tested for reliability. The mechanical structure of the scanning mirror is prepared by fused deposition modeling (FDM) using acrylonitrile butadiene styrene (ABS) as material, the radial magnetic field is provided by neodymium magnet set, and laser patterned copper foil serves as the drive coil. The prepared scanner achieved an optical scan angle of 45.2° at a resonant state of 276 Hz. The effect of temperature and humidity on the device reliability is investigated experimentally. Temperature has a significant influence on the resonance frequency and scanning angle of ABS‐based scanner. In addition, the change of relative humidity has less effect on the scanner. The five scanners tested were still working properly after 240 h (more than 2 × 108 cycles) of testing without failures and less than 1.5% frequency drift has been observed.
Single‐chain nanoparticle catalyzed polymerization toward composite nanoparticles
Authors: Xu Wei , Ye Yilan , Sun Dayin , Yang Zhenzhong 
Published: July 2023

AbstractSingle‐chain nanoparticles (SCNPs) as a confined space are promising to synthesize structured nanoparticles. We report a facile synthesis of SCNP colloidal initiators by loading reducing agents during the formation of the SCNPs and the application in redox free radical polymerization to achieve composite nanoparticles with tunable compositions and microstructures. The SCNP initiators could be large‐scale achieved by electrostatic‐mediated intramolecular crosslinking polymers by metallic complexation with protonated PVP at ambient temperature. The catalytic polymerization occurs inwardly under facile conditions to large scale fabricate composite nanoparticles with tunable microstructures from core‐shell to tadpole‐shapes. The facile approach could be extended to derive functional composite nanoparticles by loading desired materials such as paramagnetic Fe3O4, catalytic Pt, and enzymes.
A systematic pipeline of protein structure selection for computer‐aided drug discovery: A case study on T790M/L858R mutant EGFR structures
Authors: Das Agneesh Pratim , Nandekar Prajwal , Mathur Puniti , Agarwal Subhash M. 
Published: July 2023

AbstractVirtual screening (VS) is a routine method to evaluate chemical libraries for lead identification. Therefore, the selection of appropriate protein structures for VS is an essential prerequisite to identify true actives during docking. But the presence of several crystal structures of the same protein makes it difficult to select one or few structures rationally for screening. Therefore, a computational prioritization protocol has been developed for shortlisting crystal structures that identify true active molecules with better efficiency. As identification of small‐molecule inhibitors is an important clinical requirement for the T790M/L858R (TMLR) EGFR mutant, it has been selected as a case study. The approach involves cross‐docking of 21 co‐crystal ligands with all the structures of the same protein to select structures that dock non‐native ligands with lower RMSD. The cross docking performance was then correlated with ligand similarity and binding‐site conformational similarity. Eventually, structures were shortlisted by integrating cross‐docking performance, and ligand and binding‐site similarity. Thereafter, binding pose metadynamics was employed to identify structures having stable co‐crystal ligands in their respective binding pockets. Finally, different enrichment metrics like BEDROC, RIE, AUAC, and EF1% were evaluated leading to the identification of five TMLR structures (5HCX, 5CAN, 5CAP, 5CAS, and 5CAO). These structures docked a number of non‐native ligands with low RMSD, contain structurally dissimilar ligands, have conformationally dissimilar binding sites, harbor stable co‐crystal ligands, and also identify true actives early. The present approach can be implemented for shortlisting protein targets of any other important therapeutic kinases.
Promoting the activity of a receptor tyrosine phosphatase with a novel pH‐responsive transmembrane agonist inhibits cancer‐associated phenotypes
Authors: Rizzo Sophie , Sikorski Eden , Park Soohyung , Im Wonpil , Vasquez‐Montes Victor , Ladokhin Alexey S. , Thévenin Damien 
Published: July 2023

AbstractCell signaling by receptor protein tyrosine kinases (RTKs) is tightly controlled by the counterbalancing actions of receptor protein tyrosine phosphatases (RPTPs). Due to their role in attenuating the signal‐initiating potency of RTKs, RPTPs have long been viewed as therapeutic targets. However, the development of activators of RPTPs has remained limited. We previously reported that the homodimerization of a representative member of the RPTP family (protein tyrosine phosphatase receptor J or PTPRJ) is regulated by specific transmembrane (TM) residues. Disrupting this interaction by single point mutations promotes PTPRJ access to its RTK substrates (e.g., EGFR and FLT3), reduces RTK's phosphorylation and downstream signaling, and ultimately antagonizes RTK‐driven cell phenotypes. Here, we designed and tested a series of first‐in‐class pH‐responsive TM peptide agonists of PTPRJ that are soluble in aqueous solution but insert as a helical TM domain in lipid membranes when the pH is lowered to match that of the acidic microenvironment of tumors. The most promising peptide reduced EGFR's phosphorylation and inhibited cancer cell EGFR‐driven migration and proliferation, similar to the PTPRJ's TM point mutations. Developing tumor‐selective and TM‐targeting peptide binders of critical RPTPs could afford a potentially transformative approach to studying RPTP's selectivity mechanism without requiring less specific inhibitors and represent a novel class of therapeutics against RTK‐driven cancers.
Raspberry ketone feeding makes Queensland fruit fly, Bactrocera tryoni (Froggatt), more vulnerable to desiccation but not starvation
Authors: Akter Humayra , Fanson Benjamin G , Inskeep Jess , Rempoulakis Polychronis 
Published: July 2023

AbstractBackgroundQueensland fruit fly (Qfly) males exhibit accelerated sexual maturation when their diet is supplemented with raspberry ketone (RK) for 48 h following emergence, which is beneficial for sterile insect technique operation. The present study tests whether RK supplementation makes Qfly more vulnerable to starvation or desiccation.ResultsFlies were fed for 48 h with a yeast hydrolysate and sugar diet (1:3) that contained 0% RK (control), 1.25% RK (low dose) or 5% RK (high dose) to test subsequent vulnerability to starvation and desiccation. RK feeding decreased body weight and water content in males and increased lipid levels in both sexes before exposure to any stress treatment. Under nutritional stress, flies fed the low RK dose, but not the high RK dose, had higher survival than controls. Under desiccation stress, flies fed both the low and high RK doses had lower survival than the controls. Body weight, water content and lipid reserves at death were all affected by RK dose when under nutritional stress, but not when under desiccation stress. In the absence of stress, body weight at death was higher than controls in flies provided with the high RK dose and lipids were lower than controls in flies provided with the low RK dose.ConclusionFeeding with RK makes Qflies more vulnerable to desiccation but not starvation. In most conditions, it is expected that the disadvantage of increased desiccation vulnerability would be outweighed by the benefits of accelerated sexual maturation in RK‐fed young adult Qflies. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Optimal scheme and estimation for a bivariate step‐stress accelerated life test with the inverse Weibull distribution under type‐I progressive censored samples
Authors: Alotaibi Refah , Almetwally Ehab M. , Wang Min , Rezk Hoda 
Published: July 2023

AbstractIn this paper, we provide an optimization design for a step‐stress accelerated life test (ALT) with two stress variables when the lifespan of test units is assumed to follow the inverse Weibull (IW) distribution. We first utilize progressive type‐I censoring and accelerated life testing to shorten the time and reduce cost of testing and then adopt a cumulative exposure (CE) model to look at the impact of varying stress levels. A log‐linear relationship between the scale parameter of the IW distribution and stress has been postulated. We obtain the maximum likelihood estimators and Bayes estimators of the unknown model parameters. Under normal operating conditions, we design an optimal test plan via minimizing the asymptotic variance (AV) of the percentile life. We carry out simulation studies to illustrate the performance and optimality of the proposed model. Finally, a real‐life data is analyzed for illustrative purposes.
Terrace‐Like 2D Hierarchically Porous Iron/Cobalt Metal–Organic Framework: Ambient Fast Synthesis and Efficient Oxygen Evolution Reaction Application
Authors: Gao Tian , Cai Yan , Wan Qian , Deng Peixuan , Cai Qun , Peng Na , Xu Huan , Liu Yi 
Published: July 2023

AbstractIt is urgent to design a low‐cost electrocatalyst with high activity to enhance the efficiency of oxygen evolution reaction (OER), which is limited by the slow four‐electron transfer kinetics process. Nevertheless, traditional synthetic methods, including calcination and solvothermal, of the electrocatalysts are high‐cost, low‐yield, and energy‐hogging, which limits their industrial application. Herein, an ambient fast synthetic method is developed to prepare terrace‐like Fe/Co bimetal‐organic framework (TFC‐MOF) electrocatalyst materials in gram scale in 1 h. The method in this paper is designable based on coordination chemistry. Fe and Co ions can coordinate with the carboxyl groups on benzene‐1,3,5‐tricarboxylic acid (H3BTC) to form a 2D‐MOF structure. Structural characterizations, including SEM, TEM, and XRD are conducted to verify that the TFC‐MOF is a terrace‐like layered structure with uniform‐sized mesoporous, which reduces the adsorption steric hindrance and facilitates the mass and electron transfer efficiency of OER. The TFC‐MOF shows low overpotential, 255 mV at a current density of 10 mA cm−2, and a low Tafel slope of 49.9 mV dec−1, in an alkaline solution. This work provides a planar coordination strategy to synthesize 2D‐MOF OER electrocatalyst on a large scale with low cost and low energy consumption, which will promote its practical OER applications.
Thin Solid Polymer Electrolyte with High‐Strength and Thermal‐Resistant via Incorporating Nanofibrous Polyimide Framework for Stable Lithium Batteries
Authors: Wang Zhenxing , Sun Jianqi , Liu Rui , Ba Zhaohu , Dong Jie , Zhang Qinghua , Zhao Xin 
Published: July 2023

AbstractPolyethylene oxide (PEO) based polymer electrolytes show promise in expanding the practical applications of lithium (Li) batteries. However, their applications in Li batteries are usually restricted owing to the lack of mechanical strength, poor oxidative stability, and relatively large thickness. Herein, a nanofibrous polyimide (PI) framework enhanced plasticized‐PEO solid electrolyte is prepared to realize good mechanical and electrochemical performances. Following the configuration with the PI matrix, this “polymer in polymer” composite electrolyte with a thickness of 17.5 µm exhibits enhanced mechanical strength (13.9 MPa) and outstanding thermal stability. Additionally, it preserves the high ionic conductivity (2.25 × 10−4 S cm−1, 25 °C). The Li||Li symmetrical battery with the modified electrolyte could achieve a steady Li plating/stripping of more than 500 h, and the critical current density reaches up to 0.6 mA cm−2 at ambient temperature. The LiFePO4 batteries delivery favorable capacity of 132.2 mAh g−1 with capacity retentions of 96.4% and 85.9% after 500 and 1000 cycles at 1 C, respectively. Acceptable cycling performance also could be achieved in LiNi0.5Co0.2Mn0.3O2 solid batteries via an inorganic‐rich artificial cathode electrolyte interphase.
Plasmon‐Driven Photochemical Reduction Reaction on Silver Nanostructures for Green Fabrication of Superhydrophobic Surface
Authors: Chao Shengmao , Shao Hong , Wang Xiao , Zhang Yongzheng , Jiang Ruifeng , Fan Meikun , Chen Shuwei , Tang Changyu 
Published: July 2023

AbstractGreen fabrication of superhydrophobic surface by water‐based processing is still challenging, because introduction of the substances with hydrophilic moieties compromises its superhydrophobicity. Herein, a plasmon‐driven photochemical reduction reaction under ultraviolet light (UVA) irradiation is first discovered and is applied to deoxygenation of hydrophilic organic adsorbates on rough nano‐Ag coating for the formation of stable superhydrophobic surface. A nano‐Ag coating with strong localized surface plasmon resonance in the UVA region is prepared by a water‐based silver mirror reaction and results in a unique chemical reduction reaction on its surface. Consequently, the low residual hydrophilic functionalities and the formed cross‐linked structure of the adsorbate on Ag nanoparticles (NPs) enables the coating to exhibit stable superhydrophobicity against to both air and water. The superhydrophobic Ag NP‐coated sandpaper can also be used as a surface‐enhanced Raman scattering (SERS) substrate to concentrate aqueous analytes for trace detection.
Efficient Photocatalytic H2O2 Production Ability of a Novel Graphitic Carbon Nitride/Carbon Composites under Visible Light
Authors: Liang Huagen , Wang Anhu , Cheng Ruolin , Tian Xinlong , Jing Shengyu , Tsiakaras Panagiotis 
Published: July 2023

AbstractIn the present work, using one‐step calcination of a mixture made of potassium hydroxide (KOH), melamine, and microplastics, this work prepares a novel graphitic carbon nitride/carbon (g‐C3N4/C) composite, which can be employed to photo‐catalytically produce hydrogen peroxide (H2O2) at a high rate up to 6.146 mmol g−1 h−1 under visible light irradiation. By analyzing the energy band structure of the catalyst, the production of H2O2 in this system consists of two single‐electron reactions. The modification of KOH makes abundant N‐vacancies caused by cyano‐groups in g‐C3N4, enhancing the electron absorption ability. Moreover, the introduction of graphitic carbon increases its specific surface area and porosity and improves the adsorption ability of O2. Simultaneously, their synergism reduces the g‐C3N4 band gap, making both the conduction‐band and valence‐band positions more negative, showing enhanced reduction ability, lowering the energy barrier for oxygen reduction, and greatly improving the photogeneration performance of H2O2.
Bimetallic MOF‐Derived Solar‐Triggered Monolithic Adsorbent for Enhanced Atmospheric Water Harvesting
Authors: Luo Fan , Liang Xianghui , Chen Weicheng , Wang Shuangfeng , Gao Xuenong , Zhang Zhengguo , Fang Yutang 
Published: July 2023

AbstractThe development of economical, energy‐saving, and efficient metal‐organic framework (MOF)‐based adsorbents for atmospheric water collection is highly imperative for the rapid advancement of renewable freshwater resource exploitation. Herein, a feasible one‐step solvothermal formation strategy of bimetallic MOF (BMOF) is proposed and applied to construct a solar‐triggered monolithic adsorbent for enhanced atmospheric water collection. Benefiting from the reorganization and adjustment of topology structure by Al atoms and Fe atoms, the resultant BMOF(3) consisting of Al‐fumarate and MIL‐88A has a higher specific surface area (1202.99 m2 g−1) and pore volume (0.51 cm3 g−1), thereby outperforming the parental MOFs and other potential MOFs in absorbing water. Expanding upon this finding, the solar‐triggered monolithic adsorbent is further developed through a bottom‐up assembly of polyaniline/chitosan layers and hybridized BMOF(3) skeletons on a glass fiber support. The resultant monolithic adsorbent exhibits superior sorption‐desorption kinetics, leading to directional water transport and rapid solar‐assisted vapor diffusion. As a proof‐of‐concept demonstration, an exquisite water harvester is constructed to emphasize a high water yield of 1.19 g g−1 per day of the designed monolithic adsorbent. Therefore, the design and validation of bimetallic MOF‐derived solar‐triggered adsorbent in this work are expected to provide a reference for the large‐scale applications of MOF‐based atmospheric water harvesting.
Rapid Detection and Selective Extraction of Au(III) from Electronic Waste Using an Oxime Functionalized MOF‐on‐MOF Heterostructure
Authors: Mei Douchao , Yan Bing 
Published: July 2023

AbstractGold is not only a precious resource for many industries but also a global contaminant as a result of the discharge of gold‐containing waste. Designing appropriate materials for the detection and extraction of gold is of great significance for the economy and environment. However, most reports only focus on sensing or adsorption for gold because of the difficulty of combining two functions in a single material. Herein, an oxime‐functionalized MOF‐on‐MOF heterostructure (MOF‐808@ZIF‐90‐XE) for the simultaneous detection and recovery of Au3+ is first demonstrated. The constructed hybrid material exhibits good stability, ultra‐fast response time (3.6 s) as well as excellent sensitivity for the detection of Au3+. Experimental characterizations and theoretical calculations suggest that dynamic quenching and competitive adsorption may be possible sensing mechanisms. In addition, MOF‐808@ZIF‐90‐XE shows outstanding selectivity and admirable adsorption capacity (1575 mg g−1) for the capture of Au3+ owing to high surface area and abundant active adsorption sites. This paper provides a new strategy by designing a hybrid MOF‐on‐MOF heterostructure for the detection and extraction of gold.
Capacitive and Diffusive Contributions in Supercapacitors and Batteries: A Critique of b‐Value and the ν–ν1/2 Model
Authors: Pervez Sheharyar , Iqbal Muhammad Zahir 
Published: July 2023

Electrochemical energy storage devices run on two fundamentally different processes: charge storage across the double layer and redox reactions. A satisfactory understanding of the underlying mechanism is only possible once the two contributions are deconvoluted. The b‐value and the ν −ν1/2 model are two familiar steps undertaken to separate these contributions but as it is shown here both metrics are flawed, prone to misinterpretation, frequently invoked without attention to their limitations, and in need of re‐examination. After exploring these flaws through the lens of a diverse set of cyclic voltammetry data we opine that use of the b‐value be discouraged on account of subjectivity inherent to the metric, and the ν −ν1/2 model be replaced by the one proposed here. This new model ultimately reduces the root mean square error significantly and provides a robust tool for the evaluation of energy storage devices.
Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression
Authors: Tao Zhigang , Huang Jing , Li Jun 
Published: July 2023

AbstractIntroductionAs the sixth most common type of cancer worldwide, liver hepatocellular carcinoma (LIHC) emerges as grave public health danger owing to its chemotherapy‐resistant feature. Disulfidoptosis is a newly discovered programmed cell death process affecting the normal actin cytoskeleton structure.MethodsSingle‐cell RNA (scRNA)‐seq data were procured from GSE149614 and GSE202642 datasets. We utilized uniform manifold approximation and projection and clustering algorithm Louvian for dimensionality reduction and FindAllMarkers function for determining the differentially expressed genes (DEGs). Monocle2 and SCENIC were utilized to perform pseudo‐time series and transcription factor analysis for selected subgroups. A series of in vitro experiments, including colony formation assay (CFA), flow cytometry targeting apoptosis and cell cycle, was applied to investigate how APLP2 regulated the LIHC progression. Two cell lines of LIHC cells, HepG2, and Huh7, were used for si‐APLP2 transfection.ResultsTumor heterogeneity landscape of LIHC was depicted by detailed subgroup analysis. We found T and B cells were enriched with POU2F1 and HES1 activity. Inflammatory cancer‐associated fibroblasts interacted with the cancer cells, uniquely through COL1A1/SDC1, COL1A2/SDC1 and LUM/ITGB1 pathways. The transformation from normal hepatocytes to malignant cells was displayed by cell trajectory analysis. State4, which was determined as malignant cells, was enriched in PI3K, hypoxia, and Epidermal growth factor receptor pathway, and enriched with Nuclear Receptor Subfamily 2 Group F Member 1 transcription factor activity. We observed an intense communication from the cancer cells to endothelial cells, mainly through the Vitronectin (VTN) to Kinase Insert Domain Receptor (KDR) pathway. A prognostic model targeting LIHC was constructed based on the disulfidoptosis‐based DEGs, namely APLP2, PDIA6, YBX1, SPP1, whose accuracy was validated in multiple cohorts. Knockdown of APLP2 significantly increased the apoptosis and delayed cell cycle progression of LIHC cell line.ConclusionA prognostic model targeting LIHC was constructed based on the disulfidoptosis‐related DEGs, which displayed high stability and accuracy in multiple cohorts. APLP2 played an active role in the carcinogenesis of LIHC by regulating the apoptosis and cell cycle.
Wogonin alleviates BaP‐induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression
Authors: Ni Zhenhua , Ma Honghong , Li Xiaodong , Zou Liwei , Liu Zongjun , Wang Xiongbiao , Ma Hong , Yang Ling 
Published: July 2023

AbstractBenzo[a]pyrene (BaP) is a common air pollutant that has been reported to cause oxidative stress and carcinogenesis. Wogonin, a flavonoid compound extracted from the roots of Scutellaria baicalensis, has been found to possess a variety of pharmacological activities, including anti‐inflammatory and anti‐cancer effects. The purpose of this study was to examine the ability of wogonin to alleviate the cytotoxicity induced by BaP in human airway epithelial cells and explore the corresponding mechanism. Our study found that wogonin treatment inhibited DNA damage and reactive oxygen species overproduction induced by BaP in human airway epithelial cells. In vitro enzyme assays showed that wogonin significantly inhibited the enzymatic activity of CYP1A1. In addition, wogonin decreased the basal level of CYP1A1 and inhibited the CYP1A1 overexpression induced by BaP, whereas overexpression of CYP1A1 partially reversed the effect of wogonin on BaP‐induced DNA damage. Meanwhile, a CYP1A1 inhibitor and CYP1A1 knockdown also showed these same effects. Further studies showed that wogonin regulates CYP1A1 expression by inhibiting CDK7 and CDK9 activity. The use of CDK7 or CDK9 inhibitors decreased BaP‐induced cytotoxicity and CYP1A1 expression. Finally, we found that the methoxy group of wogonin was crucial for its inhibitory activity. In conclusion, our data indicated that wogonin could effectively relieve BaP induced cytotoxicity, and its mechanism was related to the dual inhibition of CYP1A1 activity and expression.