bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal cerebellum connectivity patterns related to motor subtypes of Parkinson’s disease
Authors: Chen Zhenzhen , He Chentao , Zhang Piao , Cai Xin , Huang Wenlin , Chen Xi , Xu Mingze , Wang Lijuan , Zhang Yuhu 
Published: March 2023

AbstractCerebellar dysfunction may substantially contribute to the clinical symptoms of Parkinson’s disease (PD). The role of cerebellar subregions in tremors and gait disturbances in PD remains unknown. To investigate alterations in cerebellar subregion volumes and functional connectivity (FC), as well as FC between the dentate nucleus (DN) and ventral lateral posterior nucleus (VLp) of the thalamus, which are potentially involved in different PD motor subtypes. We conducted morphometric and resting-state functional connectivity analyses in various cerebellar subregions in 22 tremor-dominant (TD)-PD and 35 postural instability gait difficulty dominant (PIGD)-PD patients and 38 sex- and age-matched healthy controls (HCs). The volume and FC alterations in various cerebellar subregions and the neural correlates of these changes with the clinical severity scores were investigated. The PIGD-PD group showed greater FC between the right motor cerebellum (CBMm) and left postcentral gyrus than the HC group, and a higher FC was associated with less severe PIGD symptoms. In contrast, the TD-PD group had decreased FC between the right DN and left VLp compared with the PIGD-PD and HC groups, and lower FC was associated with worse TD symptoms. Furthermore, the PIGD-PD group had higher FC between the left DN and left inferior temporal gyrus than the TD-PD group. Morphometric analysis revealed that the TD-PD group showed a significantly higher volume of left CBMm than the HC group. Our findings point to differential alteration patterns in cerebellar subregions and offer a new perspective on the pathophysiology of motor subtypes of PD.
Regional precipitation frequency analysis for 24-h duration using GPM and L-moments approach in South China
Authors: Chen Xiaoyang , Zhu Dehua , Wang Min , Liao Yifan 
Published: March 2023

AbstractThere are little researchers that combined satellite-based products and L-moments methods in frequency analysis. The objective of this study was to explore and evaluate the satellite precipitation data applied in univariate L-moments method. The Shaoguan City of South China was selected as the study area. Annual maximum precipitation (AMP) respectively from observational rainfall and Integrated Multi-satellitE Retrievals for Global Precipitation Mission (IMERG) gridded rainfall was used for the calculation of estimates using regional L-moments analysis (RLMA) method. Then, the quantiles at grids were corrected by mean bias correction (MBC) method with the estimates at sites. The results showed that the number of homogeneous regions as well as the spatial distribution of parameters ($${C}_{v}$$Cv,$${C}_{s}$$Cs, and$${C}_{k}$$Ck) for two data sets are different. When the return periods are larger than 40 years, the estimates at sites are also larger than those at grids and the difference will increase as return period increases. After being modified, the quantiles from IMERG are more reasonable and combine the spatial distribution characteristic of estimates from two cases, which indicates that the estimation calculated by satellite products with L-moments approach is applicable and more reasonable. This study can also provide reference for solving the issues regarding the density and coverage of rain gauges that affect the accuracy of frequency analysis, especially in remote areas of China or most parts of the word.
Bias in Gene-by-Environment Interaction Effects with Sum Scores; An Application to Well-being Phenotypes
Authors: Pelt Dirk H.M. , Schwabe Inga , Bartels Meike 
Published: March 2023

AbstractIn the current study, we investigated the influence of using skewed sum scores on estimated gene-by-environment interaction effects (GxE) for life satisfaction and happiness with perceived social support. To this end, we analyzed item-level data from a large adult twin sample (Ns between 3610 and 11,305) of the Netherlands Twin Register. Item response theory (IRT) models were incorporated in unmeasured (univariate) GxE models, and measured GxE models (with social support as moderator). We found that skewness introduced spurious GxE effects, with the largest effect for the most skewed variable (social support). Finally, in the IRT model for life satisfaction, but not for happiness, heritability estimates decreased with higher social support, while this was not observed when analyzing sum scores. Together, our results indicate that IRT can be used to address psychometric issues related to the use of sum scores, especially in the context of GxE, for complex traits like well-being.
Natural soils in OECD 222 testing — influence of soil water and soil properties on earthworm reproduction toxicity of carbendazim
Authors: Aderjan Eva , Wagenhoff Eiko , Kandeler Ellen , Moser Thomas 
Published: March 2023

AbstractSoil sorption properties can influence the bioavailability of substances and consequently the toxicity for soil organisms. Current standardised laboratory testing for the exposure assessment of pesticides to soil organisms uses OECD artificial soil that does not reflect the high variation in chemical-physical soil properties found in natural agroecosystems. According to guideline OECD 222, earthworm reproduction tests withEisenia fetidaand the pesticide carbendazim were performed in four natural soils and OECD artificial soil. By using pF 1.6, which ensures a uniformity inactual soil water availability, the control reproduction performance ofE. fetidain all natural soils was at the same level as OECD artificial soil. In a principle component analysis, the variation in toxicity between the tested soils was attributable to a combination of two soil properties, namely total organic carbon content (TOC) and pH. The largest difference of 4.9-fold was found between the typical agricultural Luvisol with 1.03% TOC and pH 6.2 (EC10: 0.17 (0.12–0.21) mg a.i. kg−1sdw, EC50: 0.36 (0.31–0.40) mg a.i. kg−1sdw) and OECD artificial soil with 4.11% TOC and pH 5.6 (EC10: 0.84 (0.72–0.92) mg a.i. kg−1sdw, EC50: 1.07 (0.99–1.15) mg a.i. kg−1sdw). The use of typical agricultural soils in standardised laboratory earthworm testing was successfully established with using the measure pF for soil moisture adjustment. It provides a more application-oriented approach and could serve as a new tool to refine the environmental risk assessment at lower tier testing or in an intermediate tier based approach.
An Ostensive Information Architecture to Enhance Semantic Interoperability for Healthcare Information Systems
Authors: Guo Hua , Scriney Michael , Liu Kecheng 
Published: March 2023

AbstractSemantic interoperability establishes intercommunications and enables data sharing across disparate systems. In this study, we propose an ostensive information architecture for healthcare information systems to decrease ambiguity caused by using signs in different contexts for different purposes. The ostensive information architecture adopts a consensus-based approach initiated from the perspective of information systems re-design and can be applied to other domains where information exchange is required between heterogeneous systems. Driven by the issues in FHIR (Fast Health Interoperability Resources) implementation, an ostensive approach that supplements the current lexical approach in semantic exchange is proposed. A Semantic Engine with an FHIR knowledge graph as the core is constructed using Neo4j to provide semantic interpretation and examples. The MIMIC III (Medical Information Mart for Intensive Care) datasets and diabetes datasets have been employed to demonstrate the effectiveness of the proposed information architecture. We further discuss the benefits of the separation of semantic interpretation and data storage from the perspective of information system design, and the semantic reasoning towards patient-centric care underpinned by the Semantic Engine.
Percutaneous left atrial appendage occlusion in patients with a cardiac implantable electronic device
Authors: Staal D. P. , Maarse M. , Aarnink E. , Huijboom M. F. M. , Abeln B. G. S. , Rensing B. J. M. W. , Swaans M. J. , Van Dijk V. F. , Boersma L. V. A. 
Published: March 2023

Abstract
Background
Left atrial appendage occlusion (LAAO) may be a viable option for stroke prevention in patients with non-valvular atrial fibrillation and a contraindication for oral anticoagulation. No evidence evaluating the safety of this procedure in patients with a cardiac implantable electronic device (CIED) exists. The aim of this study was to evaluate whether CIED function is affected by LAAO and to explore LAAO procedural characteristics and complications in patients with a CIED.

Methods
This single-center cohort study included consecutive patients scheduled for percutaneous LAAO. Patients with a CIED prior to LAAO were selected and compared to the patients without CIED, concerning procedural characteristics and peri-procedural complications. In the group of patients with CIEDs, essential pacemaker integrity parameters were compared before and after the procedure to detect possible micro and macro lead displacements.

Results
Thirty-one patients with CIED were scheduled for LAAO (age 73.7 ± 5.4 years, 65% males, CHA2DS2-VASc 4.3 ± 1.5, and HAS-BLED 3.3 ± 1.0). The 245 patients without CIED were younger, and HAS-BLED-score was slightly lower (69.4 ± 8.2 years, p < 0.001; 2.8 ± 1.0, p = 0.022). Patients without CIED more frequently underwent LAAO combined with catheter ablation (p = 0.002). All other procedural characteristics were comparable between both groups. No visible lead displacement was observed on chest X-ray after LAAO. Additionally, no differences in impedance, threshold, or intracardiac sensing in various CIED lead locations were found prior versus post LAAO.

Conclusion
This study supports the feasibility and safety of LAAO in patients with a CIED.
Measurement and Prediction of Molar Volumes of Bivalent Metal Sulfates and Their Mixtures in Aqueous Solution
Authors: Vielma Tuomas , Hnedkovsky Lubomir , Hefter Glenn 
Published: March 2023

AbstractDensities of aqueous solutions of MnSO$$_4$$

4

, CoSO$$_4$$

4

, NiSO$$_4$$

4

and CuSO$$_4$$

4

have been measured by vibrating tube densimetry up to near-saturation concentrations over the temperature range 293.15 $$\le T/$$

≤
T
/

K $$\le $$
≤
343.15 at 5 K intervals and at 0.1 MPa pressure. Apparent molar volumes, $$V_\phi $$

V
ϕ

, calculated from the densities revealed close similarities among all four electrolytes, with their $$V_\phi $$

V
ϕ

values essentially differing by constant concentration-independent addends for each salt at each temperature. It was found that there is an almost linear relationship between $$V_\phi $$

V
ϕ

(MSO$$_4$$

4

,aq) and the M–O bond length of the hydrated cations obtained from structural studies. This relationship can be used to predict values of $$V_\phi $$

V
ϕ

(MSO$$_4$$

4

,aq) for other sulfate salts over wide ranges of concentration and temperature, providing that the requisite structural data are available. Measurements of selected ternary, quaternary and quinary mixtures of these electrolytes at constant total concentrations showed that their $$V_\phi $$

V
ϕ

values almost always exhibit linear mixing (Young’s rule) behavior at all temperatures investigated. This finding can be exploited to predict the volumetric properties of solutions containing complex mixtures of bivalent metal sulfates.
The expressive case for animal self-consciousness
Authors: García Rodríguez Ángel 
Published: March 2023

AbstractAn obstacle for the attribution of self-consciousness to animals is that they lack the linguistic ability to use the first-person pronoun. To overcome the obstacle, current tests rely on the availability of behavioural measures of self-consciousness in the absence of language. However, this is not sufficient, for unless a distinction is drawn between epistemic and expressive varieties of self-consciousness, further puzzles threaten the validity of the research. This paper defends the distinction and shows how to re-evaluate current research into animal self-consciousness in its light, so as to improve conceptual clarity in this area.
Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer
Authors: Győrffy Balázs 
Published: March 2023

AbstractProgress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually at an advanced stage, there is a high demand for reliable prognostic biomarkers capable of the selection of effective chemo- and targeted therapies. Our goal was to establish a large-scale transcriptomic database and use it to uncover and rank survival-associated genes. Ovarian cancer cohorts with transcriptome-level gene expression data and clinical follow-up were identified from public repositories. All samples were normalized and entered into an integrated database. Cox univariate survival analysis was performed for all genes and was followed by multivariate analysis for selected genes involving clinical and pathological variables. False discovery rate was computed for multiple hypothesis testing and a 1% cutoff was used to determine statistical significance. The complete integrated database comprises 1816 samples from 17 datasets. Altogether, 2468 genes were correlated to progression-free survival (PFS), and 704 genes were correlated with overall survival (OS). The most significant genes were WBP1L, ASAP3, CNNM2, and NCAPH2 for progression-free survival and CSE1L, NUAK1, ALPK2, and SHKBP1 for overall survival. Genes significant for PFS were also preferentially significant for predicting OS as well. All data including HR andpvalues as well as the used cutoff values for all genes for both PFS and OS are provided to enable the ranking of future biomarker candidates across all genes. Our results help to prioritize genes and to neglect those which are most likely to fail in studies aiming to establish new clinically useful biomarkers and therapeutic targets in serous ovarian cancer.
Comparative sustainability assessment of lithium-ion, lithium-sulfur, and all-solid-state traction batteries
Authors: Popien Jan-Linus , Thies Christian , Barke Alexander , Spengler Thomas S. 
Published: March 2023

Abstract
Purpose
Traction batteries are a key component for the performance and cost of electric vehicles. While they enable emission-free driving, their supply chains are associated with environmental and socio-economic impacts. Hence, the advancement of batteries increasingly focuses on sustainability next to technical performance. However, due to different system definitions, comparing the results of sustainability assessments is difficult. Therefore, a sustainability assessment of different batteries on a common basis considering the three sustainability dimensions is needed.

Methods
This paper investigates the sustainability of current and prospective traction battery technologies for electric vehicles. It provides a common base for the comparison of the predominant lithium-ion batteries with new technologies such as lithium-sulfur and all-solid-state batteries regarding the environmental and socio-economic impacts in their supply chain. A life cycle sustainability assessment of ten battery types is carried out using a cradle-to-gate perspective and consistent system boundaries. Four environmental impact categories (climate change, human toxicity, mineral resource depletion, photochemical oxidant formation), one economic performance indicator (total battery cost), and three social risk categories (child labor, corruption, forced labor) are analyzed.

Results
The assessment results indicate that the new battery technologies are not only favorable in terms of technical performance but also have the potential to reduce environmental impacts, costs, and social risks. This holds particularly for the lithium-sulfur battery with solid electrolyte. The environmental benefits are even amplified with a higher share of renewable energy for component and battery production. Nevertheless, hotspots related to the high energy demand of production and the supply chain of the active materials remain.

Conclusions
This article emphasizes the need to evaluate different battery technologies on a common basis to ensure comparability of the results and to derive reliable recommendations. The results indicate that the lithium-sulfur battery with solid electrolyte is preferable since this battery has the best indicator scores for all impact categories investigated. However, all-solid-state batteries are still under development so that no conclusive recommendation can be made, but further development of these battery technologies appears promising.
Relationship between Internet Use and Negative Affect
Authors: Zheng Hongyun , Ma Wanglin , Li Junpeng , Botero Julio 
Published: March 2023

AbstractWhile positive emotions like happiness and life satisfaction have received great attention, how to eliminate negative affect is largely neglected. This study contributes to the literature by examining the relationship between Internet use and people’s negative affect. Unlike previous studies that consider only one indicator, we capture negative affect from different dimensions by considering loneliness, sadness, and life hardship. We employ an endogenous ordered probit model to address the selection bias of Internet use and analyze the 20,107 individual-level samples sourced from the 2020 China Family Panel Studies survey. The results show that Internet use significantly reduces people’s loneliness, sadness, and life hardship. We also find that studying online and watching short videos would increase people’s loneliness feeling and shopping online deepens people’s life hardship. In contrast, using WeChat significantly reduces sadness and life hardship. Our findings confirm that guiding people to use the Internet appropriately is necessary to reduce negative affect and improve the quality of their life.
Development of a method for downscaling ecological footprint and biocapacity to a 1-km square resolution
Authors: Hori Keiko , Shirahama Shuji , Hashimoto Shizuka , Saito Osamu , Matsui Takanori , Haga Chihiro 
Published: March 2023

AbstractIn this study, we propose a method for downscaling ecological footprint (EF) and biocapacity (BC) to a 1-km square resolution for a spatially flexible analysis of environmental burden balance. To conduct EF downscaling (by land type and consumption category) for all terrestrial areas of Japan, the grid population was multiplied by the scaled EF per capita based on the consumption expenditures and income statistics available at the municipal level. The BC of each land type was estimated following the land-use map. Subsequently, a balance analysis between EF and BC showed the spatial distribution of EF, BC, and the environmental load excess ratio (EF/BC). The values of the environmental load excess ratio significantly varied between grids, and the spatial distributions differed depending on the land type. An example of multiscale balance analysis at municipal and prefectural scales by the developed dataset showed the different distributions of the environmental load excess ratio due to the scale of spatial boundaries and demonstrated its contribution to designing interregional cooperative policies from a multilayered perspective. The established high-resolution dataset can be utilized practically for flexibly analyzing the multilayered spatial boundaries to fill the scale mismatch between natural resources and administrative boundaries. The downscaling method proposed in this study can be applied beyond Japan if similar sets of statistics and land-use information are available, which will significantly improve the spatial resolution of the analysis.
Psychosocial experiences of breast cancer survivors: a meta-review
Authors: R. King , L. Stafford , P. Butow , S. Giunta , R. Laidsaar-Powell 
Published: March 2023

Abstract
Purpose
Advances in breast cancer care have led to a high rate of survivorship. This meta-review (systematic review of reviews) assesses and synthesises the voluminous qualitative survivorship evidence-base, providing a comprehensive overview of the main themes regarding breast cancer survivorship experiences, and areas requiring further investigation.

Methods
Sixteen breast cancer reviews identified by a previous mixed cancer survivorship meta-review were included, with additional reviews published between 1998 and 2020, and primary papers published after the last comprehensive systematic review between 2018 and 2020, identified via database searches (MEDLINE, Embase, CINAHL, PsycINFO). Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Systematic Reviews and the CASP (Critical Appraisal Skills Programme Qualitative) checklist for primary studies. A meta-ethnographic approach was used to synthesise data.

Results
Of 1673 review titles retrieved, 9 additional reviews were eligible (25 reviews included in total). Additionally, 76 individual papers were eligible from 2273 unique papers. Reviews and studies commonly focused on specific survivorship groups (including those from ethnic minorities, younger/older, or with metastatic/advanced disease), and topics (including return to work). Eight themes emerged: (1) Ongoing impact and search for normalcy, (2) Uncertainty, (3) Identity: Loss and change, (4) Isolation and being misunderstood, (5) Posttraumatic growth, (6) Return to work, (7) Quality of care, and (8) Support needs and coping strategies.

Conclusions
Breast cancer survivors continue to face challenges and require interventions to address these.
Implications for Cancer Survivors.
Breast cancer survivors may need to prepare for ongoing psychosocial challenges in survivorship and proactively seek support to overcome these.
Caveolin-1-Mediated Cholesterol Accumulation Contributes to Exaggerated mGluR-Dependent Long-Term Depression and Impaired Cognition in Fmr1 Knockout Mice
Authors: Luo Li , Yang Le , Zhang Kun , Zhou Shi-Meng , Wang Yan , Yang Liu-Kun , Feng Bin , Liu Shui-Bing , Wu Yu-Mei , Zhao Ming-Gao , Yang Qi 
Published: March 2023

Abstract
Fragile X syndrome (FXS) is one of the most common inherited mental retardation diseases and is caused by the loss of fragile X mental retardation protein (FMRP) expression. The metabotropic glutamate receptor (mGluR) theory of FXS states that enhanced mGluR-dependent long-term depression (LTD) due to FMRP loss is involved in aberrant synaptic plasticity and autistic-like behaviors, but little is known about the underlying molecular mechanism. Here, we found that only hippocampal mGluR-LTD was exaggerated in adolescent Fmr1 KO mice, while N-methyl-D-aspartate receptor (NMDAR)-LTD was intact in mice of all ages. This development-dependent alteration was related to the differential expression of caveolin-1 (Cav1), which is essential for caveolae formation. Knockdown of Cav1 restored the enhanced mGluR-LTD in Fmr1 KO mice. Moreover, hippocampal Cav1 expression in Fmr1 KO mice induced excessive endocytosis of the α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluA2. This process relied on mGluR1/5 activation rather than NMDAR. Interference with Cav1 expression reversed these changes. Furthermore, massive cholesterol accumulation contributed to redundant caveolae formation, which provided the platform for mGluR-triggered Cav1 coupling to GluA2. Importantly, injection of the cholesterol scavenger methyl-β-cyclodextrin (Mβ-CD) recovered AMPA receptor trafficking and markedly alleviated hyperactivity, hippocampus-dependent fear memory, and spatial memory defects in Fmr1 KO mice. Together, our findings elucidate the important role of Cav1 in mediating mGluR-LTD enhancement and further inducing AMPA receptor endocytosis and suggest that cholesterol depletion by Mβ-CD during caveolae formation may be a novel and safe strategy to treat FXS.