bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of body mass index from childhood to mid-adulthood with health-related quality of life in mid-adulthood
Authors: Tian Jing , Blizzard Leigh , Campbell Julie A. , Gall Seana , Dwyer Terence , Venn Alison 
Published: September 2023

Abstract
Purpose
Most studies regarding the association of obesity with health-related quality of life (HRQoL) have assessed obesity at only one or two time points. We aimed to examine the associations of life course body mass index (BMI) from childhood with health-related quality of life (HRQoL) in mid-adulthood.

Methods
Data were from a cohort study of Australian children (n = 2254, mean baseline age 12.0 (2.0) years in 1985, 46.8% male). Weight and height were measured at baseline and measured or self-reported on average 20, 25, and 30 years later. Age and sex-standardised BMI-z score was calculated at each time point. Physical and mental HRQoL and health state utilities (HSUs) were measured by SF-12 and SF-6D at the last adult follow-up. Linear regression was used to examine the associations adjusting for age, sex, and childhood health status.

Results
Higher BMI-z score in childhood (βadjusted − 1.39, 95% CI − 1.73 to − 1.05) and increasing BMI-z score from childhood to young adulthood (βadjusted − 1.82, 95% CI − 2.17 to − 1.46) and from young to mid-adulthood (βadjusted − 1.77, 95% CI − 2.28 to − 1.26) were associated with lower physical HRQoL in mid-adulthood. Similar results were found for mid-adulthood HSUs (βadjusted ranged − 0.006 to − 0.014, all P < 0.05). Only increasing BMI-z score from young to mid-adulthood significantly related to poorer mental HRQoL (βadjusted − 0.74, 95% CI − 1.29 to − 0.19) in mid-adulthood.

Conclusion
High BMI from childhood to mid-adulthood had only modest associations with HRQoL and HSUs, with effects on physical HRQoL most apparent.
Modelling the Effect of Matrix Metalloproteinases in Dermal Wound Healing
Authors: Dari Sonia , Fadai Nabil T. , O’Dea Reuben D. 
Published: September 2023

AbstractWith over 2 million people in the UK suffering from chronic wounds, understanding the biochemistry and pharmacology that underpins these wounds and wound healing is of high importance. Chronic wounds are characterised by high levels of matrix metalloproteinases (MMPs), which are necessary for the modification of healthy tissue in the healing process. Overexposure of MMPs, however, adversely affects healing of the wound by causing further destruction of the surrounding extracellular matrix. In this work, we propose a mathematical model that focuses on the interaction of MMPs with dermal cells using a system of partial differential equations. Using biologically realistic parameter values, this model gives rise to travelling waves corresponding to a front of healthy cells invading a wound. From the arising travelling wave analysis, we observe that deregulated apoptosis results in the emergence of chronic wounds, characterised by elevated MMP concentrations. We also observe hysteresis effects when both the apoptotic rate and MMP production rate are varied, providing further insight into the management (and potential reversal) of chronic wounds.
Early discharge and home treatment of patients with acute pulmonary embolism in the tertiary care setting
Authors: Nopp Stephan , Bohnert Julia , Mayr Thomas , Steiner Daniel , Prosch Helmut , Lang Irene , Behringer Wilhelm , Janata-Schwatczek Karin , Ay Cihan 
Published: September 2023

AbstractAcute pulmonary embolism (PE) is a potentially life-threatening disease. Current guidelines suggest risk-adapted management. Hospitalization is required for intermediate- and high-risk patients. Early discharge and home treatment are considered safe in the majority of low-risk patients. In this study, we describe characteristics, discharge, and outcome of outpatients diagnosed with acute PE at a tertiary care center. All outpatients undergoing computed tomography pulmonary angiography or ventilation/perfusion lung scan between 01.01.2016 and 31.12.2019 at the University Hospital Vienna, Austria, were screened for a PE diagnosis. Electronic patient charts were used to extract characteristics, clinical course, and outcomes. Within the 4-year period, 709 outpatients (median age: 62 years, 50% women) were diagnosed with PE. Thirty-three (5%) patients were classified as high-risk, 159 (22%) as intermediate-high, 332 (47%) as intermediate-low, and 185 (26%) as low-risk PE according to the European Society of Cardiology risk stratification. In total, 156 (22%) patients (47% with low-risk and 20% with intermediate-low-risk PE) were discharged as outpatients and received home treatment. Rates for home treatment increased 2.4-fold during the study period. Thirty-day mortality in the entire population was 4.9%. All low-risk patients and all but one patient with home treatment survived the first 30 days. Home treatment significantly increased over time and seems to be safe in routine clinical practice. Notably, one in five intermediate-low-risk patients was discharged immediately, suggesting that a subpopulation of intermediate-low-risk patients may also be eligible for home treatment.
Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice
Authors: Guo Huijuan , Liu Xinxu , Chen Ti , Wang Xiaoping , Zhang Xiaojie 
Published: September 2023

AbstractAccumulating evidence has suggested that the gut microbiome plays an important role in depression. Akkermansia muciniphila (AKK), a next-generation probiotic, shows a beneficial effect on immune and metabolic homeostasis. The relative abundance of AKK was found negatively correlated with depressive symptoms in both clinical and pre-clinical studies. To evaluate the potential antidepressant effect of AKK and explore the possible mechanism, we used chronic alcohol exposure and chronic unpredictable mild stress (CUMS) to induce depressive-like behaviors in mice. We found that oral AKK administration significantly reduced the immobility time in the force swimming test (FST) and tail suspension test (TST) in the mice with chronic alcohol exposure and the CUMS mice. The sucrose preference in the mice receiving AKK was significantly increased in the sucrose preference test (SPT). More importantly, AKK implantation significantly increased the level of 5-HT in the gut and PFC of both the alcohol exposure mice and the CUMS mice. Furthermore, AKK had inhibited the expression of SERT in the gut but not in the brain for both NIAAA and the CUMS model mice. Interestingly, the expression of cFos in enteric nerves in the gut significantly decreased after AKK administration. In conclusion, our study demonstrated the antidepressant effect of AKK in mice exposed to alcohol exposure and CUMS, with the potential mechanism that AKK implantation might lead to an increased level of 5-HT and inhibited SERT expression in the gut, and might alter the gut-to-brain signal through suppression of enteric nerves activation.
Flexibility for whom? Householder and stakeholder perspectives on justice regarding the introduction of dynamic grid tariffs in Norway
Authors: Winther Tanja , Sundet Øyvind 
Published: September 2023

AbstractThis paper presents the results from a qualitative research project in Norway on a forthcoming change in electricity grid tariffs. As a form of Demand Side Management to avoid capacity constraints in the grid, the new tariff seeks to reduce consumption peaks by incentivising householders to even out electricity use and shift to nighttime. We examine the perspectives of 13 representatives from grid companies as well as 22 householders and study the process of developing the tariffs, in which the researchers took part at certain times. We draw on previous studies on experts’ perceptions of end-users, social practice theory, and energy justice, and we employ the concept of flexibility capital to examine the situation of the participating households. The findings partly confirm results from previous studies showing that experts may have a simplistic view of end-users and by observing an unequal distribution of flexibility capital across the studied households. However, the study contributes to the field by observing a link between householders’ sentiments towards the new tariff and their respective levels of affluence and flexibility capital. Then, we explicitly address justice perspectives related to the tariff’s introduction as perceived by grid companies and householders and find that both groups voice a need to acknowledge the situation of different kinds of end-users. We discuss the results from an energy justice perspective and observe that details in the design of a DSM mechanism may dampen its negative effects.
Office Obligation as Civil Virtue: The Crisis of American Democracy, November 3, 2020–January 6, 2021, and After
Authors: Alexander Jeffrey C. 
Published: September 2023

AbstractThis essay develops a new theoretical and empirical understanding of the contemporary crisis of American democracy. Between November 3, 2020, and January 7, 2021, President Donald Trump battled to overturn the results of the American presidential election, launching myriad lawsuits and pressuring hundreds of electoral officials. Confronting this antidemocratic assault was a resilient civil sphere that sustained “office,” an institution that, in a democratic society, inspires faith in the Constitution and loyalty to “we the people.” After investigating how this civil institution empowered electoral and legal officials to fight off Trumpian pressures, I focus on Georgia Secretary of State Brad Raffensperger and US Vice President Mike Pence, examining how they emerged as widely admired icons of civil courage. After Trump’s defeat, the televised hearings of the January 6th Commission created a “civic ritual” in the midst of which Wyoming Congresswoman Liz Cheney became another icon, symbolizing the renewal of a “civil conservatism.” A new, if still precarious, vital center emerged, allowing Democratic prosecutors finally to launch criminal proceedings against Trump. Yet, the Republican Party remains unreconstructed and, for this reason, the future of American democracy is still in doubt.
Stable Isotope Dilution LC/ESI-SRM/MS Analysis for Highly Polar Bioactive Dipeptides Found in Fermented Brown Rice Product using a Porous Graphitic Carbon Column
Authors: Ono Sawaka , Hatakawa Yusuke , Lee Seon Hwa , Oe Tomoyuki 
Published: September 2023

AbstractIn this study, a validated analytical method based on liquid chromatography/electrospray ionization-selected reaction monitoring/mass spectrometry (LC/ESI-SRM/MS) was developed for dipeptides in a functional food, fermented brown rice and rice bran with Aspergillus oryzae (FBRA). The aim of this study was to screen and quantify dipeptides in the water-soluble fraction of FBRA. There are few studies focusing on dipeptides in FBRA, even though FBRA is expected to contain bioactive peptides: FBRA or its aqueous extract has shown variety of biological activities. An anti-hypertensive dipeptide was found in similar rice bran products digested by thermolysin. Dipeptides are the smallest class of peptides, and many show a variety of biological activities. Some bioactive peptides are widely found in fermented foods. However, because dipeptides are generally too polar to be retained on versatile LC columns, such as octadecylsilyl columns, dipeptides have been often overlooked and not quantified because of the analytical difficulties. The LC was performed using a porous graphitic carbon column with the mobile phases of 0.1% formic acid/0.1% trifluoroacetic acid/1% tetrahydrofuran in water and acetonitrile. The stable isotope-labeled internal standards and SRM for dipeptides made it possible to develop a validated method. Five dipeptides were identified and quantified in FBRA in much higher concentrations than related materials (malted brown rice, rice bran, brown rice, and white rice) as follows: Ile-Arg, 82.1 µg/g; Ala-Phe, 27.8 µg/g; Ala-Tyr, 31.6 µg/g; Val-Phe, 46.3 µg/g; and Ile-Tyr, 49.9 µg/g. This method was simple and robust and would be applicable for other functional foods.
Graphical Abstract
Safety, pharmacokinetics, and efficacy of belantamab mafodotin monotherapy in Japanese patients with relapsed or refractory multiple myeloma: DREAMM-11
Authors: Iida Shinsuke , Sunami Kazutaka , Mishima Yuko , Fujii Taku , Kato Hitomi , Terao Takumi , Matsuzawa Yuki , Matsubara Mari , Crossman Timothy , Kremer Brandon E. , Gupta Ira 
Published: September 2023

AbstractBelantamab mafodotin, a B-cell maturation antigen-targeting antibody–drug conjugate (ADC), was investigated in Japanese patients with relapsed/refractory multiple myeloma in Part 1 of the phase I DREAMM-11 study. Patients who had received ≥ 2 prior lines of therapy including a proteasome inhibitor and immunomodulatory agent were eligible. Eight patients received belantamab mafodotin monotherapy at 2.5 mg/kg (n = 4) or 3.4 mg/kg (n = 4) by intravenous infusion every 3 weeks on day 1 of each cycle until disease progression or unacceptable toxicity. Primary objectives were tolerability and safety, and secondary objectives included pharmacokinetics (PK) and efficacy. The most common Grade ≥ 3 adverse event was thrombocytopenia/platelet count decreased (2.5 mg/kg cohort, 100% [4/4]; 3.4 mg/kg cohort, 75% [3/4]), and no dose-limiting toxicities were observed. Ocular events, including keratopathy findings, were observed in most patients (2.5 mg/kg cohort, 100% [4/4]; 3.4 mg/kg cohort, 75% [3/4]) and were managed with dose modifications. All resolved within the study period. Overall response rates were 50% (2/4) in the 2.5 mg/kg cohort and 25% (1/4) in the 3.4 mg/kg cohort. Although PK profiles in Japanese patients varied, individual exposures overlapped with previous results in Western populations. Belantamab mafodotin monotherapy was generally well-tolerated and demonstrated clinical activity at both doses.
Burden of foodborne disease in low-income and middle-income countries and opportunities for scaling food safety interventions
Authors: Grace Delia 
Published: September 2023

AbstractFoodborne diseases (FBD) are an important externality of agriculture and food systems, but only since 2015 have they risen up the development agenda. In the first part of this Review, I discuss the multiple burdens of FBD and how they relate to food systems with a focus on low-income and middle-income countries (LMIC), particularly African nations. The health burden of FBD is comparable with that of malaria, and over 90% falls on people in LMIC, with an economic burden of more than US$100 million per year. FBD have many other, less well-estimated effects on nutrition, gender, equity, and the environment. FBD are becoming increasingly prevalent in LMIC and many outbreaks are attributable to nutritious, fresh foods purchased from informal markets. In the second part of the paper, I consider options for improved management of FBD at scale in LMIC. I summarize previous investments in Africa, finding that they have often been poorly directed and evaluated. Finally, on the basis of a systematic literature review, I make recommendations for an integrated framework to evaluate food safety interventions in LMIC, including a typology for interventions and five factors critical for success. Incorporating these factors into food safety interventions will ensure that they are scalable and sustainable.
Mathematics identity instrument development for fifth through twelfth grade students
Authors: Cribbs Jennifer D. , Utley Juliana 
Published: September 2023

AbstractGiven the importance of mathematics identity for students continued participation and engagement with mathematics, it is important for educators and researchers to be able to explore students’ mathematics identity development. However, an instrument with validity evidence that can be used to explore mathematics identity efficiently and with groups of students is not currently available. This article draws on prior research to test and validate items for a mathematics identity instrument to be used with fifth through twelfth grade students. This study includes 1559 participants from two school districts in a midwestern state in the USA. Analysis includes assessing four components of validity including content validity, internal structure, relationship to other variables, and generalization. Findings provide evidence for the reliability and validity of the items in the mathematics identity scale, giving researchers and educators a way to explore this construct efficiently.
Langetermijneffecten van de behandeling van patiënten met testiskanker: implicaties voor nazorg en follow-up
Authors: Lubberts Sjoukje , Gietema Jourik A. 
Published: September 2023

SamenvattingTestiskanker is goed te behandelen. De vijfjaarsoverleving is momenteel > 90%. Testiskanker wordt meestal vóór het 40e jaar gediagnosticeerd, en patiënten kunnen na een succesvolle behandeling nog 40 tot 50 jaar leven. Er is echter een verhoogd risico op langdurige en late effecten van deze behandeling. Tweede primaire maligniteiten en hart- en vaatziekten zijn daarvan de meest voorkomende en potentieel levensbedreigende. Andere zijn nefrotoxiciteit, neurotoxiciteit, verminderde vruchtbaarheid, hypogonadisme, chronische vermoeidheid en psychosociale problemen. Over de onderliggende mechanismen en de genetische gevoeligheid voor de verschillende bijwerkingen is nog weinig bekend, waardoor het niet goed mogelijk is om patiënten met een hoog risico op bepaalde late effecten te identificeren. Wij presenteren de huidige stand van zaken betreffende verschillende somatische en psychosociale langetermijneffecten na behandeling en formuleren aanbevelingen voor algemene medische evaluaties, die moeten beginnen bij start van de behandeling en doorgaan na voltooien van de behandeling en de follow-up.
Centenarians: who are they? A description of the total Swedish centenarian population in terms of living arrangements, health, and care utilization
Authors: Murata Shunsuke , Meyer Anna C. , Ebeling Marcus , Modig Karin 
Published: September 2023

Abstract
Background
The global centenarian population has doubled each decade and is expected to continue growing. However, information regarding how they live, their health status, and care needs is limited.

Aims
This study aims to describe the total Swedish centenarian population in terms of health status, living arrangements, and socio-demographic characteristics.

Methods
This nationwide register-based study included all Swedish people reaching age 100 between 2013 and 2018. We analyzed their socio-demographic characteristics, living arrangements, number of prescribed drugs, and health status. Moreover, their care transitions from age 100 and two years forward were described.

Results
Of 5,882 centenarians (80.7% women), only 15.0% lived at home without formal care and 24.5% cohabited on their 100th birthday. Men (22.7%) were more likely than women (13.2%) to live at home without care. Approximately half of the centenarians lived in care homes, with fewer men (41.0%) than women (54.0%). Around 66.6% had a child living within the 50 km range. Most (76.5%) had an income below the median for Swedish older adults. Almost none were free from drugs, and polypharmacy was common (65.3%). Over half had at least one morbidity. Two years later, only 4.3% lived at home without care, and 63.9% died.

Conclusion
Sweden’s centenarian population is highly dependent on home care and care homes. Among the ones still living at home, the vast majority live alone and have low incomes. Strategies to manage health and social care demands of this growing population group in the coming decade are important.
Bone fragility and osteoporosis in children and young adults
Authors: Formosa M. M. , Christou M. A. , Mäkitie O. 
Published: September 2023

AbstractOsteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly individuals, especially postmenopausal women, are particularly susceptible to osteoporosis. Although rare, osteoporosis in children and young adults is becoming increasingly evident, highlighting the need for timely diagnosis, management and follow-up. Early-onset osteoporosis is defined as the presence of a low BMD (Z-score of ≤ −2.0 in individuals aged < 20 years; T-score of ≤ −2.5 in those aged between 20 to 50 years) accompanied by a clinically significant fracture history, or the presence of low-energy vertebral compression fractures even in the absence of osteoporosis. Affected children and young adults should undergo a thorough diagnostic workup, including collection of clinical history, radiography, biochemical investigation and possibly bone biopsy. Once secondary factors and comorbidities are excluded, genetic testing should be considered to determine the possibility of an underlying monogenic cause. Defects in genes related to type I collagen biosynthesis are the commonest contributors of primary osteoporosis, followed by loss-of-function variants in genes encoding key regulatory proteins of canonical WNT signalling (specifically LRP5 and WNT1), the actin-binding plastin-3 protein (encoded by PLS3) resulting in X-linked osteoporosis, and the more recent sphingomyelin synthase 2 (encoded by SGMS2) which is critical for signal transduction affecting sphingomyelin metabolism. Despite these discoveries, genetic causes and underlying mechanisms in early-onset osteoporosis remain largely unknown, and if no causal gene is identified, early-onset osteoporosis is deemed idiopathic. This calls for further research to unravel the molecular mechanisms driving early-onset osteoporosis that consequently will aid in patient management and individualised targeted therapy.
Urban green spaces and their relationship with groundwater quality: the case of a shallow aquifer in the south of Mexico City
Authors: Canteiro Marcelo , Arellano-Aguilar Omar , Bravo José Elías Becerril , Zambrano Luis 
Published: September 2023

AbstractWater supply security is a top priority for decision-makers in cities. Urban population growth increases water demand from aquifers, while urban expansion reduces water infiltration and boosts water pollution sources. Urban green spaces are a few of the remaining infiltration areas. Therefore, they are essential for water supply and urban hydric resilience. The urban dynamic directly influences shallow aquifers, but they usually are unappreciated. This work illustrates the relationship between urban green spaces and city water quality by evaluating the influence of urban green space, Reserva Ecológica del Pedregal de San Angel (REPSA), on a shallow aquifer in Mexico City. Five springs were sampled: two upstream of REPSA, a spring within REPSA, and two downstream. Because the study area is mainly residential but with an industrial history, water quality was tested based on microbiological pathogens, nutrients, pharmaceutical drugs, and heavy metals. Results showed an enhancement of water quality of the shallow aquifer in the sampling points downstream of REPSA for some of the pollutants. These results illustrate how urban green spaces can help to dilute pollutants present in the water of shallow aquifers, increasing water quality in cities.