bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary TNF-α as a potential biomarker for chronic primary low back pain
Authors: Gevers-Montoro Carlos , Puente-Tobares Mariana , Monréal Aléxiane , Conesa-Buendía Francisco Miguel , Piché Mathieu , Ortega-De Mues Arantxa 
Published: June 2023

IntroductionOver two thirds of individuals with low back pain (LBP) may experience recurrent or persistent symptoms in the long term. Yet, current data do not allow to predict who will develop chronic low back pain and who will recover from an acute episode. Elevated serum levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) have been associated with poor recovery and persistent pain following an acute episode of LBP. Inflammatory cytokines may also mediate mechanisms involved in nociplastic pain, and thus, have significant implications in chronic primary low back pain (CPLBP).MethodsThis study aimed to investigate the potential of urinary TNF-α levels for predicting outcomes and characterizing clinical features of CPLBP patients. Twenty-four patients with CPLBP and 24 sex- and age-matched asymptomatic controls were recruited. Urinary TNF-α concentrations were measured at baseline and after 4 weeks, during which CPLBP patients underwent spinal manipulative therapy (SMT).ResultsConcentrations of TNF-α were found to be elevated in baseline urine samples of CPLBP patients compared to asymptomatic controls. Moreover, these values differed among patients depending on their pain trajectory. Patients with persistent pain showed higher levels of TNF-α, when compared to those with episodic CPLBP. Furthermore, baseline TNF-α concentrations and their changes after 4 weeks predicted alterations in pain intensity and disability following SMT in patients with CPLBP.DiscussionThese findings warrant further research on the potential use of urinary TNF-α concentrations as a prognostic biomarker for CPLBP.
LC–MS-based serum metabolomics analysis for the screening and monitoring of colorectal cancer
Authors: Yi Yanan , Wang Jianjian , Liang Chengtong , Ren Chuanli , Lian Xu , Han Chongxu , Sun Wei 
Published: June 2023

BackgroundColorectal Cancer (CRC) is a prevalent digestive system tumour with significant mortality and recurrence rates. Serum metabolomics, with its high sensitivity and high throughput, has shown potential as a tool to discover biomarkers for clinical screening and monitoring of the CRC patients.MethodsSerum metabolites of 61 sex and age-matched healthy controls and 62 CRC patients (before and after surgical intervention) were analyzed using a ultra-performance liquid chromatography-high resolution mass spectrometer (UPLC-MS). Statistical methods and pathway enrichment analysis were used to identify potential biomarkers and altered metabolic pathways.ResultsOur analysis revealed a clear distinction in the serum metabolic profile between CRC patients and healthy controls (HCs). Pathway analysis indicated a significant association with arginine biosynthesis, pyrimidine metabolism, pantothenate, and CoA biosynthesis. Univariate and multivariate statistical analysis showed that 9 metabolites had significant diagnostic value for CRC, among them, Guanosine with Area Under the Curve (AUC) values of 0.951 for the training group and0.998 for the validation group. Furthermore, analysis of four specific metabolites (N-Phenylacetylasparticacid, Tyrosyl-Gamma-glutamate, Tyr-Ser and Sphingosine) in serum samples of CRC patients before and after surgery indicated a return to healthy levels after an intervention.ConclusionOur results suggest that serum metabolomics may be a valuable tool for the screening and monitoring of CRC patients.
Case report: long-term sustained remission in a case of metastatic colon cancer with high microsatellite instability and KRAS exon 2 p.G12D mutation treated with fruquintinib after local radiotherapy: a case report and literature review
Authors: Wang Ruiqi , Cong Dan , Bai Yuansong , Zhang Wenlong 
Published: June 2023

To demonstrate the efficacy of fruquintinib administration after local radiotherapy in a patient with metastatic colon cancer with high microsatellite instability and the KRAS exon 2 p. G12D mutation. The patient was administered four cycles of pembrolizumab intravenous infusion and achieved stable disease as the best outcome. He was then underwent follow-up concurrent radiochemical therapy (local DT4600cGy/23f/32d radiotherapy, and S-1 to increase sensitivity to radiotherapy), but this had little efficacy. Following this, he was administered fruquintinib and achieved sustained partial remission. At the time of last follow-up, the patient was in continuous remission for 30 months. Administration of fruquintinib after local radiotherapy may be an effective treatment for specific populations with metastatic colorectal cancer.
A systematic review and meta-regression of exogenous ketone infusion rates and resulting ketosis—A tool for clinicians and researchers
Authors: Storoschuk Kristi L. , Wood Thomas R. , Stubbs Brianna J. 
Published: June 2023

Introduction:Ketone bodies such as beta-hydroxybutyrate (BHB) have pleiotropic functional benefits as fuel and signaling metabolites and may have multiple clinical applications. An alternative to inducing ketosis by dietary modification is intravenous delivery of exogenous sources of ketones. It is unknown whether there is a strong relationship between BHB infusion rate and blood BHB concentrations in the published literature; this information is vital for clinical studies investigating therapeutic effects of ketosis. This systematic review aimed to aggregate available data and address this gap.Methods:The PubMed and EMBASE databases were searched, and data were extracted from 23 manuscripts where BHB was infused and maximum and/or steady state BHB levels assessed. Infusion rate was adjusted when racemic BHB was infused but onlyD-BHB was measured.Results:Using a random effects meta-regression, strong linear relationships between BHB infusion rate and maximal (y = 0.060 + 0.870x,R2= 87.2%,p&lt; 0.0001) and steady state (y = −0.022 + 0.849x,R2= 86.9%,p&lt; 0.0001) blood BHB concentrations were found. Sensitivity analysis found this relationship was stronger when studies in non-healthy populations were excluded (y = 0.059 + 0.831x,R2= 96.3%,p&lt; 0.0001).Conclusion:There is a strong relationship between BHB infusion rate and blood BHB concentrations; the regressions described here can be used by clinicians or researchers to determine ketone delivery required for a target blood concentration.
Prevalence and severity of anxiety and depression in Chinese patients with breast cancer: a systematic review and meta-analysis
Authors: Tao Fuying , Xu Mengnan , Zou Qi , Tang Lin , Feng Jianping , Li Zhenyu 
Published: June 2023

ContextAnxiety/depression in breast cancer (BC) is common around the world, and Chinese BC patients should not be ignored. The prevalence of anxiety and depression among BC patients are various in different regions of China, but no clear summarization has been made.PurposeThis meta-analysis aimed to evaluate the prevalence and severity of anxiety and depression among breast cancer (BC) patients in China.MethodsA literature search on PubMed, Web of Science, Embase, CINAHL, Scopus, PsycINFO, Cochrane database library, CNKI, Wanfang, and SinoMed was conducted up to 29 December 2021. The effect size (ES) or standard mean difference (SMD) and the corresponding 95% confidence intervals (CIs) for the prevalence and severity of anxiety/depression were calculated using the STATA 12.0 software.ResultsA total of 63 identified studies were included, containing a total of 53,513 Chinese women confirmed breast cancer. The results showed a high pooled prevalence of anxiety (38%, 95% CI, 27–50%, I2 = 99.4%, p &lt; 0.001) and depression (38%, 95% CI, 33–44%, I2 = 99.2%, p &lt; 0.001) among Chinese BC patients. Moreover, both anxiety (SMD = 0.30, 95% CI, 0.08–0.53, I2 = 91.6%, p &lt; 0.001) and depression (SMD = 0.25, 95% CI, −0.05–0.55, I2 = 95.3%, p &lt; 0.001) in BC patients were more serious than those in healthy controls, but not significantly different from patients with other diseases. Specifically, among the six regions included, the prevalence of anxiety and depression were both the highest in Northeast China, obviously superior than the second-highest region.ConclusionThe study showed high levels of anxiety and depression among BC patients in China, especially those in the northeast. Clinicians and researchers should pay attention to the psychological problems of patients with breast cancer and regard it as one of the important prognostic outcomes of patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/index.php, PROSPERO: CRD42020151752.
An exploration of the correlations between seven psychiatric disorders and the risks of breast cancer, breast benign tumors and breast inflammatory diseases: Mendelian randomization analyses
Authors: Ren Fei , Shang Qingyao , Zhao Shuangtao , Yang Chenxuan , Feng Kexin , Liu Jiaxiang , Kang Xiyu , Zhang Ruixuan , Wang Xiang , Wang Xin 
Published: June 2023

BackgroundPrevious observational studies have showed that certain psychiatric disorders may be linked to breast cancer risk, there is, however, little understanding of relationships between mental disorders and a variety of breast diseases. This study aims to investigate if mental disorders influence the risks of overall breast cancer, the two subtypes of breast cancer (ER+ and ER-), breast benign tumors and breast inflammatory diseases.MethodsDuring our research, genome-wide association study (GWAS) data for seven psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, post-traumatic stress disorder, panic disorder, obsessive-compulsive disorder and anorexia nervosa) from the Psychiatric Genomics Consortium (PGC) and the UK Biobank were selected, and single-nucleotide polymorphisms (SNPs) significantly linked to these mental disorders were identified as instrumental variables. GWAS data for breast diseases came from the Breast Cancer Association Consortium (BCAC) as well as the FinnGen consortium. We performed two-sample Mendelian randomization (MR) analyses and multivariable MR analyses to assess these SNPs’ effects on various breast diseases. Both heterogeneity and pleiotropy were evaluated by sensitivity analyses.ResultsWhen the GWAS data of psychiatric disorders were derived from the PGC, our research found that schizophrenia significantly increased the risks of overall breast cancer (two-sample MR: OR 1.05, 95%CI [1.03-1.07], p = 3.84 × 10−6; multivariable MR: OR 1.06, 95%CI [1.04-1.09], p = 2.34 × 10−6), ER+ (OR 1.05, 95%CI [1.02-1.07], p = 5.94 × 10−5) and ER- (two-sample MR: OR 1.04, 95%CI [1.01-1.07], p = 0.006; multivariable MR: OR 1.06, 95%CI [1.02-1.10], p = 0.001) breast cancer. Nevertheless, major depressive disorder only showed significant positive association with overall breast cancer (OR 1.12, 95%CI [1.04-1.20], p = 0.003) according to the two-sample MR analysis, but not in the multivariable MR analysis. In regards to the remainder of the mental illnesses and breast diseases, there were no significant correlations. While as for the data from the UK Biobank, schizophrenia did not significantly increase the risk of breast cancer.ConclusionsThe correlation between schizophrenia and breast cancer found in this study may be false positive results caused by underlying horizontal pleiotropy, rather than a true cause-and-effect relationship. More prospective studies are still needed to be carried out to determine the definitive links between mental illnesses and breast diseases.
Network analysis of frontal lobe alpha asymmetry confirms the neurophysiological basis of four subtypes of depressive behavior
Authors: Sharpley Christopher F. , Bitsika Vicki , Arnold Wayne M. , Shadli Shabah M. , Jesulola Emmanuel , Agnew Linda L. 
Published: June 2023

IntroductionAlthough depression is widespread carries a major disease burden, current treatments remain non-universally effective, arguably due to the heterogeneity of depression, and leading to the consideration of depressive “subtypes” or “depressive behavior subtypes.” One such model of depressive behavior (DB) subtypes was investigated for its associations with frontal lobe asymmetry (FLA), using a different data analytic procedure than in previous research in this field.Methods100 community volunteers (54 males, 46 females) aged between 18 yr. and 75 years (M = 32.53 yr., SD = 14.13 yr) completed the Zung Self-rating Depression Scale (SDS) and underwent 15 min of eyes closed EEG resting data collection across 10 frontal lobe sites. DB subtypes were defined on the basis of previous research using the SDS, and alpha-wave (8-13 Hz) data produced an index of FLA. Data were examined via network analysis.ResultsSeveral network analyses were conducted, producing two models of the association between DB subtypes and FLA, confirming unique neurophysiological profiles for each of the four DB subtypes.DiscussionAs well as providing a firm basis for using these DB subtypes in clinical settings, these findings provide a reasonable explanation for the inconsistency in previous FLA-depression research.
Case report: Diagnosis and treatment of delayed epidural pyogenic abscess after brain tumor operation: a report of 5 cases and review of the literature
Authors: Shen HePing , Lin YingCong , Chu ZhengMin , Wang GengHuan , Chu WenLai 
Published: June 2023

ObjectiveTo explore the clinical manifestations and treatment of delayed epidural pyogenic abscess after brain tumor surgery.MethodTo retrospectively analyze the medical records of 5 patients with delayed epidural pyogenic abscess after brain tumor surgery in our hospital from January 2010 to December 2020, including clinical manifestations, laboratory results, imaging findings, treatment measures, prognosis, etc. The causes of epidural abscesses were analyzed, and the treatment methods and prognosis were evaluated.ResultAmong the 5 cases, there were 4 male and 1 female patient, aged 52–75 years. Three cases were gliomas and 2 cases were meningiomas. Four cases received postoperative radiotherapy, and 1 case had open frontal sinus during operation. None of the surgical incisions were infected. The time between the tumor surgery and the discovery of an epidural abscess was 1.5 to 24 months. All 5 patients had headaches, 1 case had a fever, and 2 cases had limb dysfunction. Three cases had elevated blood inflammatory markers. MRI- DWI showed restricted diffusion. All 5 patients underwent surgery, 4 patients had bone flap removed, and 1 patient had bone flap retained. Bacterial culture was positive in 3 cases and negative in 2 cases. All 5 cases were cured, followed up for 1.5–9 years, and no epidural abscess recurred.ConclusionThe clinical manifestations and laboratory results of delayed epidural pyogenic abscess after brain tumor surgery are not specific, but MRI-DWI has specificity. Postoperative radiotherapy for brain tumors and intraoperative opening of the frontal sinus may be associated with delayed epidural pyogenic abscess. For patients with normal skin flap and no serious inflammation of the bone flap, clinicians can attempt to preserve the bone flap.
Hot Workability Investigation of an Fe-Al-Ta Alloy Using Deformation Processing Maps
Authors: Emdadi Aliakbar , Michels Heiner , Tovar Michael 
Published: June 2023

Fe-Al-Ta alloys are expected to replace high-alloyed steels in steam turbine blades. However, the mechanical properties of the forged blades are still not optimal due to limited grain refinement during hot forging and the coarse-grained microstructure inherited from the as-cast precursor. It is, therefore, essential to investigate the hot deformation behavior of the alloy to identify the optimum range for the deformation parameters leading to good hot workability with significant grain refinement. The hot deformation behavior and hot workability of an Fe-25Al-1.5Ta (at.%) alloy were investigated in the present work using constitutive modeling and the concept of processing maps. Uniaxial compression tests were conducted in a strain rate range from 0.0013 s−1 to 1 s−1 and in a temperature range from 900 °C to 1100 °C, where a disordered A2 α-(Fe, Al) matrix phase along with a C14-(Fe, Al)2Ta Laves phase were confirmed by X-ray diffraction. The flow stress–strain curves showed a broad maximum followed by a slight drop in stress until a steady state was reached. The optimum processing window for the studied alloy was located at 910–1060 °C/0.0013–0.005 s−1, where the efficiency of the power dissipation (η) and strain rate sensitivity (m) reached 50% and 0.33, respectively. The material underwent a combination of dynamic recovery and dynamic recrystallization over the whole tested deformation range. No flow instabilities were predicted based on Prasad’s flow instability criterion when deformation was performed up to a true strain of 0.5 and 0.8, indicating a high degree of hot workability of the studied alloy over the entire deformation range tested. The current study reveals a well-suited parameter range for the safe and efficient deformation of Fe-Al-Ta alloys, which may contribute to the optimization of the thermomechanical processing of this alloy.
Therapeutic Potential of Bioactive Compounds from Brugmansia suaveolens Bercht. & J. Presl
Authors: da Costa Sandro Pinheiro , Schuenck-Rodrigues Raphaela Aparecida , Cardoso Verônica da Silva , Valverde Simone Sacramento , Vermelho Alane Beatriz , Ricci-Júnior Eduardo 
Published: June 2023

Brugmansia suaveolens Bercht. & J. Presl has been widely used due to the presence of different bioactive compounds. This review summarizes the latest advances and perspectives of the B. suaveolens plant species; it is a systematic literature review on aspects of botany, traditional uses, phytochemistry, pharmacology, and toxicology as therapeutic potential. In addition, 120 compounds are described, including alkaloids, flavonoids, terpenoids, steroids, amino acids, aromatics, and aliphatics. As for the therapeutic potential, it is described in extracts and compounds in the antitumor, anti-inflammatory, antioxidant, antimicrobial, antispasmodic, anticoagulant, and analgesic aspects, as well as the effects on the central nervous system. The toxicity of the genus stands out, especially the potential for organ toxicity. Therefore, this review evidenced the knowledge related to the traditional use based on the scientific research of Brugmansia suaveolens, highlighting an overview of bioactive compounds and biological and toxicological activities in order to provide a scientific basis for future studies on the value of this species for the development of new natural products.
A festa do sagrado
Authors: Alves Teixeira Damasceno Willians Antonio 
Published: June 2023

O presente artigo vem analisar a festividade do candomblé conhecida como Ṣírẹ̀ Òrìṣà[1], no intuito de compreender o processo de iniciação de novos membros dentro do candomblé, tanto no sentido sagrado quanto no profano, por meio da cosmogonia dos sistemas simbólicos das narrativas míticas e da ritualização do corpo que caracteriza essa religiosidade. Nessa confraternização cosmogônica, a interpretação do renascimento, tem como intuito a representação do caminho que todos os iniciados têm que percorrer, até chegar a sua forma final transcendente, caracterizado pela energia ancestral. Dentro dessa concepção religiosa, o artigo demonstra como o Ṣírẹ̀ Òrìṣà da iniciação, apresenta para os adeptos da comunidade e para o público em geral, a cosmogênese yoruba do renascimento dentro das fases de crescimento do indivíduo, como forma de reconhecer os elementos sagrado dentro do mundo profano.

Palavras-chave: Ṣìrẹ́ Òrìṣà, Oralidade, Terreiro, Candomblé, Iniciação.

[1] Significado de “brincar” com o Òrìṣà, representa a festividade pública do candomblé de nação ketu com o intuito de promover a aproximação da comunidade religiosa com a sociedade em geral. Tem como proposito, apresentar o novo iniciado para a sociedade religiosa ou, homenagear algum Òrìṣà em data específica.
Transformaciones espaciales de un nuevo espectáculo: el caso de LR1 Radio El Mundo en la ciudad de Buenos Aires
Authors: Martínez Almudevar Paula 
Published: June 2023

Durante toda la década de 1930, los contemporáneos fueron testigos de varias transformaciones en la radiofonía porteña. Al aumento en la cantidad de horas de transmisión de las emisoras se sumó la multiplicidad de nuevos sujetos que diariamente las transitaban. Pero tal vez el cambio de mayor envergadura —ligado al constante crecimiento del medio— fue la mudanza de varias de ellas a edificios cercanos al centro porteño, buscando ser parte de la “cartografía del ocio” de la ciudad. En ese contexto comenzó la construcción de un edificio especialmente diseñado para albergar una radio: el edifico de la calle Maipú 555 —hoy Radio Nacional— donde se instalaría LR1 Radio El Mundo.
Este trabajo busca recuperar la centralidad del espacio en los procesos históricos y analizar los cambios en la espacialidad de los edificios radiales porteños durante la década de 1930, principalmente los concernientes a la emisora LR1 Radio El Mundo. Se analizan los cambios en el funcionamiento de las emisoras, las motivaciones de los mismos y el impacto de ellos en el proceso de “espectacularización” de la radiofonía, en las experiencias de trabajo de las y los trabajadores de radio y en la aparición del público.
EVALUASI PROSEDUR UANG PERSEDIAAN PADA BADAN PERTANAHAN NASIONAL PROVINSI SULAWESI UTARA
Authors: Gonting Vera , Elim Inggriani , Afandi Dhullo 
Published: June 2023

Dalam pemerintahan akun kas dipakai untuk mencatat pengelolaan Anggaran Pendapatan dan Belanja Negara (APBN), dalam pengelolaan anggaran tersebut lembaga keuangan pemerintah diharuskan mempunyai dan mengikuti sistem dan prosedur pengelolaan keuangan Negara. Uang persediaan merupakan uang yang dikelola oleh bendahara pengeluaran yang digunakan untuk keperluan operasional dan dapat dimintakan penggantian uang. Tujuan yaitu sebagai untuk mengevaluasi kesesuaian prosedur permintaan, penggunaan dan pelaporan uang persediaan di Badan Pertahanan Nasional Provinsi Sulawesi Utara dengan peraturan perundangan yang berlaku dan untuk mengevaluasi kesesuaian prosedur permintaan, penggunaan dan pelaporan uang persediaan di Badan Pertanahan Nasional Provinsi Sulawesi Utara dengan konsep sistem pengendalian internal. Metode analisis data yang digunakan dalam penelitian ini adalah metode analisis deskriptif kualitatif. Hasil penelitian menunjukan bahwa prosedur uang persediaan dan mengevaluasi kesesuaian prosedur permintaan, penggunaan dan pelaporan Uang Persediaan di Badan Pertahanan Nasional Provinsi Sulawesi Utara dengan konsep sistem pengendalian internal pada Badan Pertanahan Nasional Provinsi Sulawesi Utara telah sesuai dengan PMK No. 190/PMK.05/2012 yang diubah PMK No.178/PMK.05/2018 tentang Tata Cara Pembayaran Dalam Rangka Pelaksanaan Anggaran Pendapatan dan Belanja Negara dan seperti yang diatur dalam PP No. 60 tahun 2008 tentang Sistem Pengendalian Intern Pemerintah.

Kata Kunci: Uang Persediaan, evaluasi, prosedur