bluuebunny/crossref_metadata_2025_split huggingface dataset:
Te Ara Waiora–Implementing human papillomavirus (HPV) primary testing to prevent cervical cancer in Aotearoa New Zealand: A protocol for a non-inferiority trial
Authors: Gibson-Helm Melanie , Slater Tania , MacDonald Evelyn J. , Stevenson Kendall , Adcock Anna , Geller Stacie , Parag Varsha , Lambert Charles , Bennett Matthew , Hibma Merilyn , Sykes Peter , Saville Marion , Hawkes David , Stanton Jo-Ann , Clueard Mary-Ann , Jelley Grahame , Lawton Bev 
Published: March 2023

Background
Cervical cancer is caused by high-risk types of human papillomavirus (HPV). Testing for high-risk HPV is a more sensitive screening method than cervical cytology for detecting cervical changes that may lead to cancer. Consistent with recent evidence of efficacy and acceptability, Aotearoa New Zealand plans to introduce HPV testing as the primary approach to screening, replacing cervical cytology, from mid-2023. Any equitable cervical screening programme must be effective across a diverse population, including women that the current programme fails to reach, particularly Māori and those in rural areas. Currently, we do not know the best model for implementing an equitable HPV self-testing screening programme.

Methods
This implementation trial aims to assess whether a universal offer of HPV self-testing (offered to all people eligible for cervical screening) achieves non-inferior screening coverage (equal) to a universal offer of cervical cytology alone (the present programme). The study population is all people aged from 24.5 to 70 years due for cervical screening in a 12-month period (including those whose screening is overdue or who have never had screening). A range of quantitative and qualitative secondary outcomes will be explored, including barriers and facilitators across screening and diagnostic pathways. This study takes place in Te Tai Tokerau/Northland which covers a diverse range of urban and rural areas and has a large Indigenous Māori population. A total of fourteen practices will be involved. Seven practices will offer HPV self-testing universally to approximately 2800 women and will be compared to seven practices providing routine clinical care (offer of cervical cytology) to an approximately equal number of women.

Discussion
This trial will answer important questions about how to implement an equitable, high-quality, effective national programme offering HPV self-testing as the primary screening method for cervical cancer prevention.

Trial registration
Prospectively registered with the Australian New Zealand Clinical Trials Registry 07/12/2021: ACTRN12621001675819.
Research on the evaluation method of agricultural intelligent robot design solutions
Authors: Tang Qian , Luo Ying-Wen , Wu Xiao-Di 
Published: March 2023

Background
At present, agricultural robots are produced in large quantities and used in agricultural planting, and the traditional agricultural model is gradually shifting to rely on the Internet of Things and sensors to accurately detect crop growth information. The scientific and rational design of agricultural robots plays a huge role in planting and production efficiency, however, the factors affecting their design are complex and ambiguous, so it is necessary to use a rational evaluation system to make a preferential decision among multiple design options.

Purposes
In order to reduce the subjectivity and blindness of program selection in the process of agricultural robot design, make the decision more objective and reasonable, and thus enhance the practicality and scientificity of the program, a new comprehensive evaluation method based on user requirements is proposed.

Methods
First, after researching and interviewing users and farming operations, obtaining raw information on requirements, using the Kano model to classify the requirements and establishing an evaluation index system. Secondly, the combination of hierarchical analysis(AHP) and entropy weighting method is used to assign weights to the evaluation index system, calculate the weight value and importance ranking of each index, and carry out various program designs based on the ranking. Finally, the VIKOR method was applied to evaluate and rank the design solutions.

Results
The new evaluation method can better complete the preferential decision of the agricultural robot design scheme and get a more perfect design scheme, which reduces the influence of human subjective thinking in the decision-making process.

Conclusions
The method not only corrects the traditional evaluation method, but also effectively improves the accuracy and comprehensiveness of the design evaluation process. It also provides a reference for designers to preferably select design solutions and promotes the development of small mobile machines in the context of smart agriculture.
Predicting spinal column profile from surface topography via 3D non-contact surface scanning
Authors: Rayward Lionel , Pearcy Mark , Izatt Maree , Green Daniel , Labrom Robert , Askin Geoffrey , Little J. Paige 
Published: March 2023

Introduction
3D Non-Contact surface scanning (3DSS) is used in both biomechanical and clinical studies to capture accurate 3D images of the human torso, and to better understand the shape and posture of the spine–both healthy and pathological. This study sought to determine the efficacy and accuracy of using 3DSS of the posterior torso, to determine the curvature of the spinal column in the lateral lying position.

Methods
A cohort of 50 healthy adults underwent 3DSS and Magnetic Resonance Imaging (MRI) to correlate the contours of the external spine surface with the internal spinal column. The correlation analysis was composed of two phases: (1) MRI vertebral points vs MRI external spine surface markers; and (2) MRI external spine surface markers vs 3DSS external spine surface markers. The first phase compared the profiles of fiducial markers (vitamin capsules) adhered to the skin surface over the spinous processes against the coordinates of the spinous processes–assessing the linear distance between the profiles, and similarity of curvature, in the sagittal and coronal planes. The second phase compared 3DSS external spine surface markers with the MRI external spine surface markers in both planes, with further qualitative assessment for postural changes.

Results
The distance between the MRI vertebral points and MRI external spine surface markers showed strong statistically significant correlation with BMI in both sagittal and coronal planes. Kolmogorov-Smirnov (KS) tests showed similar no significant difference in curvature, k, in almost all participants on both planes. In the second phase, the coronal 3DSS external spine surface profiles were statistically different to the MRI external spine surface markers in 44% of participants. Qualitative assessment showed postural changes between MRI and 3DSS measurements in these participants.

Conclusion
These study findings demonstrate the utility and accuracy of using anatomical landmarks overlaid on the spinous processes, to identify the position of the spinal bones using 3DSS. Using this method, it will be possible to predict the internal spinal curvature from surface topography, provided that the thickness of the overlaying subcutaneous adipose layer is considered, thus enabling postural analysis of spinal shape and curvature to be carried out in biomechanical and clinical studies without the need for radiographic imaging.
The uptake of WHO-recommended birth preparedness and complication readiness messages during pregnancy and its determinants among Ethiopian women: A multilevel mixed-effect analyses of 2016 demographic health survey
Authors: Habte Aklilu , Tamene Aiggan , Woldeyohannes Demelash 
Published: March 2023

Background
Birth preparedness and complication readiness (BPCR) is a package of interventions recommended by the World Health Organization to improve maternal and newborn health and it is provided and implemented through a focused antenatal care program. This study aimed at assessing the uptake of birth preparedness and complication readiness messages, and compliance with each key message, among Ethiopian women during their recent pregnancies using the 2016 demographic health survey report.

Methods
The data for this study was taken from the Ethiopian Demographic and Health Survey, which was conducted from January to June 2016 and covered all administrative regions. STATA version 16 was used to analyze a total of 4,712 (with a weighted frequency of 4,771.49) women. A multilevel mixed-effects logistic, and multilevel mixed-effect negative binomial regressions were fitted, respectively. Adjusted odds ratio (AOR) and Incidence rate ratio (IRR) with their corresponding 95% confidence interval (CI) were used to report significant determinants.

Results
More than half, 56.02% [95% CI: 54.58, 57.41] of women received at least one birth preparedness and complication readiness message. Being in the richest wealth quintiles (AOR = 2.33; 95% CI: 1.43, 3.73), having two birth/s in the last five years (AOR = 1.54; 95% CI: 1.13, 2.10), receiving four or more antenatal visits(AOR = 3.33; 95% CI: 2.49, 4.45), and reading a newspaper at least once a week (AOR = 1.27; 95% CI: 1.07, 1.65) were the individual‑level factors, whereas regions and residence(AOR = 1.54; 95% CI: 1.11, 1.96) were the community-level factors associated with the uptake of at least one BPCR message. On the other hand, receiving four or more antenatal visits (IRR = 2.78; 95% CI: 2.09, 3.71), getting permission to go to a health facility (IRR = 1.29; 95% CI: 1.028, 1.38), and not covered by health insurance schemes (IRR = 0.76; 95% CI: 0.68, 0.95) were identified as significant predictors of receiving key birth preparedness and complication readiness messages.

Conclusion
The overall uptake of the WHO-recommended birth readiness and complication readiness message and compliance with each message in Ethiopia was found to be low. Managers and healthcare providers in the health sector must work to increase the number of antenatal visits. Policymakers should prioritize the implementation of activities and interventions that increase women’s autonomy in decision-making, job opportunity, and economic capability to enhance their health-seeking behavior. The local administrative bodies should also work to enhance household enrollment in health insurance schemes.
Effects of acupuncture on age-related macular degeneration: A systematic review and meta-analysis of randomized controlled trials
Authors: Sun Wu , Zhao Yuwei , Liao Liang , Wang Xueyao , Wei Qiping , Chao Guojun , Zhou Jian 
Published: March 2023

Background
In recent years, an increasing number of patients with age-related macular degeneration (AMD) have received acupuncture treatment, but there has been no systematic review to evaluate the effect of acupuncture on patients with AMD.

Purpose
This meta-analysis aims to review the clinical efficacy of acupuncture in the treatment of AMD.

Methods
Randomized controlled trials up to September 4, 2022 were searched in the following databases: PubMed, Ovid Medline, Embase, Cochrane Library, The Chinese National Knowledge Infrastructure Database, VIP, Wanfang, and SINOMED. Two reviewers independently performed literature screening and data extraction. RevMan 5.4 was used for the meta-analysis.

Results
Nine of the 226 articles were finally included. A total of 508 AMD patients (631 eyes) were enrolled, including 360 dry eyes and 271 wet eyes. The results showed that acupuncture alone or as an adjunct therapy improved both the clinical efficacy and best-corrected visual acuity (BCVA) of AMD patients and reduced their central macular thickness. The certainty of the evidence ranged from "low" to "very low".

Conclusion
There is no high-quality evidence that acupuncture is effective in treating patients with AMD; patients with dry AMD may benefit from acupuncture treatment. Considering the potential of acupuncture treatment for AMD, it is necessary to conduct a rigorously designed randomized controlled trials to verify its efficacy.
More emergency patients presenting with chest pain
Authors: Lindskou Tim Alex , Andersen Patricia Jessen , Christensen Erika Frischknecht , Søvsø Morten Breinholt 
Published: March 2023

Introduction
Throughout recent years the demand for prehospital emergency care has increased significantly. Non-traumatic chest pain is one of the most frequent complaints. Our aim was to investigate the trend in frequency of the most urgent ambulance patients with chest pain, subsequent acute myocardial infarction (AMI) diagnoses, and 48-hour and 30-day mortality of both groups.

Methods
Population-based historic cohort study in the North Denmark Region during 2012–2018 including chest pain patients transported to hospital by highest urgency level ambulance following a 1-1-2 emergency call. Primary diagnoses (ICD-10) were retrieved from the regional Patient Administrative System, and descriptive statistics (distribution, frequency) performed. We evaluated time trends using linear regression, and mortality (48 hours and 30 days) was assessed by the Kaplan Meier estimator.

Results
We included 18,971 chest pain patients, 33.9% (n = 6,430) were diagnosed with”Diseases of the circulatory system” followed by the non-specific R- (n = 5,288, 27.8%) and Z-diagnoses (n = 3,634; 19.2%). AMI was diagnosed in 1,967 patients (10.4%), most were non-ST-elevation AMI (39.7%). Frequency of chest pain patients and AMI increased 255 and 22 patients per year respectively, whereas the AMI proportion remained statistically stable, with a tendency towards a decrease in the last years. Mortality at 48 hours and day 30 in chest pain patients was 0.7% (95% CI 0.5% to 0.8%) and 2.4% (95% CI 2.1% to 2.6%).

Conclusions
The frequency of chest pain patients brought to hospital during 2012–2018 increased. One-tenth were diagnosed with AMI, and the proportion of AMI patients was stable. Almost 1 in of 4 high urgency level ambulances was sent to chest pain patients. Only 1 of 10 patients with chest pain had AMI, and overall mortality was low. Thus, monitoring the number of chest pain patients and AMI diagnoses should be considered to evaluate ambulance utilisation and triage.
Revisión y perspectivas para la construcción de bases de datos robustas con datos faltantes: caso aplicado a información financiera
Authors: Romero Gustavo Andrès , González Prieto Cristian Andrés , Díaz Barriosnuevos María Angélica , Rueda Menjura Nataly Alejandra 
Published: March 2023

Contexto: Se propone un conjunto de opciones que ayudan a determinar el método más adecuado para subsanar en bases de datos de tamaño apreciable, condiciones iniciales de datos faltantes y que serán utilizadas en procesos de investigación.
Metodología: El presente artículo aborda una propuesta para el desarrollo y manejo de bases de datos robustas como el caso de registros financieros, enfocándose desde el proceso knowledge discovery in databases (KDD).
Resultados: Se desarrolla y prueba una metodología utilizando tres técnicas de imputación en una base de datos construida a partir de 1 253 280 registros financieros de 2238 empresas y que representan siete años de su actividad económica en la localidad de Chapinero, en la ciudad de Bogotá D. C.
Conclusiones: Se realiza un comparativo de los métodos de imputación como factor determinante para la elección del método de imputación y consolidación de la base para su posterior uso.
Financiamiento: Fundación Universitaria Los Libertadores.
El sector de la construcción en el departamento del Cauca: ¿una locomotora de crecimiento en el corto y largo plazo?
Authors: Gomez-Sanchez Andres Mauricio , Ramírez-Gutiérrez Zoraida , Rivadeneira-Daza Jorge Luis 
Published: March 2023

Contexto: La teoría del crecimiento económico ha sostenido que el sector de la construcción es un jalonador del nivel de actividad económica a largo plazo, sobre todo en países emergentes como Colombia. Sin embargo, esta hipótesis podría no ser cierta para ciudades intermedias como Popayán, debido a que las dinámicas económicas no son semejantes a las de ciudades grandes.
Método: Inicialmente se implementa un modelo autorregresivo de rezagos distribuidos (ARDL, por su sigla en inglés) y un modelo de corrección del error vectorial (VMCE, por su sigla en inglés) para hallar la relación a largo plazo; posteriormente se utiliza un modelo de vectores autorregresivos (VAR, por su sigla en inglés) y un modelo autorregresivo con variables exógenas (VARX, por su sigla en inglés) para caracterizar la relación en el corto plazo, a través de ciclos económicos con la ayuda del filtro de Kalman.
Resultados: Si bien el sector de la construcción jalona la economía, como lo predijo Currie (1993c), esta relación para el Cauca es significativa en el corto plazo, pero no en el largo.
Conclusiones: Se evidencia una causalidad contraria que va desde el producto interno bruto (PIB) departamental hacia el PIB de la construcción; por tanto, se infiere que este sector no es impulsor de la actividad económica en el departamento del Cauca.
Functional roles of CD26/DPP4 in bleomycin‐induced pulmonary fibrosis
Authors: Koyanagi Yu , Kawasaki Takeshi , Kasuya Yoshitoshi , Hatano Ryo , Sato Shun , Takahashi Yukiko , Ohnuma Kei , Morimoto Chikao , Dudek Steven M. , Tatsumi Koichiro , Suzuki Takuji 
Published: March 2023

AbstractThe pathogenesis of pulmonary fibrosis involves complex interplay between cell types and signaling pathways. Recurrent alveolar epithelial injury can occur during pulmonary inflammation, causing dysregulation of epithelial repair. Dysregulated repair interacts with mesenchymal, inflammatory, and endothelial cells to trigger fibroblast‐to‐myofibroblast activation. CD26/dipeptidyl peptidase‐4 (DPP4) is a type II membrane protein mediating pleiotropic effect. However, the mechanistic role of CD26/DPP4 in pulmonary fibrosis remains unclear. In this study, we aimed to characterize Dpp4 deficiency in a mouse bleomycin (BLM)‐induced pulmonary fibrosis model and in cell culture systems of human lung fibroblasts (HLFs). Dpp4 knockout (Dpp4 KO) mouse lungs exhibited lower Ashcroft scale indices, collagen content, and numbers of fibroblasts and myofibroblasts compared with those in C57BL/6 wild‐type (WT) mice. Upregulation of Tgfb1 and Tgfb2 mRNA levels in the lungs after BLM treatment was lower in Dpp4 KO mice compared with those in WT mice. Although TGF‐β‐driven endothelial‐to‐mesenchymal transition (EndMT) has been implicated as one of the mechanisms of pulmonary fibrosis, a number of partial EndMT cells in lungs did not differ between Dpp4 KO mice and WT mice. The proliferation capacity and mRNA levels of COL1A1, a collagen deposition‐related gene, in cultured HLFs were suppressed in DPP4 small interfering RNA‐treated cells. This study indicates that the genetic deficiency of DPP4 has protective effects against BLM‐induced pulmonary fibrosis, partly through the reduction in TGF‐β expression and inhibition of fibroblast activation in the lung. Our study suggests that CD26/DPP4 inhibition is a potential therapeutic strategy for pulmonary fibrosis.
Are anti-SARS-CoV-2 S/N IgG/IgM antibodies always predictive of previous SARS-CoV-2 infection?
Authors: Lippi Giuseppe , Henry Brandon M. , Pighi Laura , De Nitto Simone , Salvagno Gian Luca 
Published: March 2023

Abstract

Objectives
We planned this study to verify whether immunoassays for quantifying anti-SARS-CoV-2 IgG/IgM antibodies against both spike (S) and nucleocapsid (N) proteins may be used for identifying previous SARS-CoV-2 infections.

Methods
The study population consisted of a cohort of fully vaccinated healthcare workers. All study subjects underwent regular medical visits and molecular testing for diagnosing SARS-CoV-2 infections every 2–4 weeks between 2020–2022. Venous blood was drawn for measuring anti-SARS-CoV-2 antibodies with MAGLUMI 2019-nCoV lgG/IgM CLIA Assays directed against both SARS-CoV-2 S and N proteins.

Results
Overall, 31/53 (58.5%) subjects had tested positive for SARS-CoV-2 by RT-PCR throughout the study (24 once, 7 twice). No positive correlation was found between anti-SARS-CoV-2 S/N IgM antibodies and molecular test positivity. In univariate regression analysis, both a molecular test positivity (r=0.33; p=0.015) and the number of positive molecular tests (r=0.43; p=0.001), but not vaccine doses (r=−0.12; p=0.392), were significantly correlated with anti-SARS-CoV-2 S/N IgG antibodies. These two associations remained significant in multiple linear regression analysis (p=0.029 and p<0.001, respectively) after adjusting for sex, age, body mass index, and vaccine doses. In ROC curve analysis, anti-SARS-CoV-2 S/N IgG antibodies significantly predicted molecular test positivity (AUC, 0.69; 95% CI; 0.55–0.84), with the best cutoff of 0.05 AU/mL displaying 67.9% accuracy, 0.97 sensitivity, and 0.27 specificity.

Conclusions
Although anti-SARS-CoV-2 S/N IgG antibodies provide helpful information for identifying previous SARS-CoV-2 infections, a lower cutoff than that of sample reactivity should be used. Anti-SARS-CoV-2 S/N IgM antibodies using conventional cutoffs seem useless for this purpose.
The impact of chemical modifications on gamma-ray attenuation properties of some WO3-reinforced tellurite glasses
Authors: ALMisned Ghada , Rabaa Elaf , Sen Baykal Duygu , Ilik Erkan , Kilic Gokhan , Zakaly Hesham M. H. , Ene Antoaneta , Tekin Huseyin Ozan 
Published: March 2023

Abstract
We report the role of the chemical modifications on various gamma-ray attenuation properties of four different tellurite glasses reinforced through WO3. The chemical compositions and glass densities are used in terms of determining some critical attenuation properties, such as linear and mass attenuation coefficients, half value layer, and effective atomic number values. Based on the rise in density, it was determined that the maximum concentration of WO3 also resulted in a significant change in the overall gamma-ray absorption properties, when all of the study’s findings were examined. It was observed that the glass sample, in which TeO2 and WO3 were 40 mol%, had the highest density. It was found that this glass with the highest density has the highest linear attenuation coefficient and mass attenuation coefficient and the lowest half value layer among the four samples specified. This demonstrates that WO3 inclusion is a functional component that may be used in tellurium glasses and is a suitable material for situations requiring increased gamma-ray absorption properties.
Attention capital in populist network communication: When the free labour of citizens maintains the spiral of attention
Authors: Sekloča Peter 
Published: March 2023

Abstract
The author thematizes the operation of the political market of attention that is propelled by the willingness of citizens to credit populist leaders with their digital political labour. Mutual, nevertheless unequal, exchange of attention leads to the formation of a spiral of attention. Its expansive character is sustained by the strategically subsidized recognition of populist leaders. Accumulated attention, i. e. attention capital, is the resource that is used to maintain populist networked public spheres, while citizens are proletarianized: they are invited to apply their labour power to distributing political ideas but are pevented from evaluating the influence of competing public actors.