bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tripartite motif–containing 9 promoted proliferation and migration of bladder cancer cells through CEACAM6-Smad2/3 axis
Authors: Zhang Zhao-Cun , Zhao Hai-Feng , Sun Zhuang , Li Yi , Zhong Ming-Lei , Wang Bao-Hai , Jiang Xian-Zhou 
Published: May 2023

AbstractStudies have shown that tripartite motif–containing (TRIM) family proteins function as E3 ubiquitin ligases and play essential roles in cancer biology. In the present study, we validated a contribution of TRIM9 to bladder cancer progression. 296 patients derived from The Cancer Genome Atlas (TCGA) database and 22 clinical specimens were included, in which accumulated TRIM9 correlated with the poor prognosis and higher relapse in bladder patients. In vitro, TRIM9 promoted bladder cancer cells Biu-87 and T24 cell proliferation and migration. Meanwhile, overexpression of TRIM9 reduced the chemosensitivity in Biu-87 and T24 to mitomycin C (MMC) and gemcitabine (GEM). As an underlying mechanism, we found that TRIM9 stimulated carcinoembryonic antigen 6 (CEACAM6) upregulation, which further facilitated Smad2/3-matrix metalloproteinase 2 (MMP2) signaling activation both in vitro and in vivo. Those results indicated that TRIM9 facilitated bladder cancer development and chemoresistance by CEACAM6-Smad2/3 axis. TRIM9 and its associated molecules could be a potential diagnostic indicator and therapeutic target in bladder cancer.
Graphic Abstract
Developing human factors design guidelines for marine electronics — the case of S-mode
Authors: Vu Viet Dung , Lützhöft Margareta , Imset Marius 
Published: May 2023

AbstractHuman factors issues with navigation equipment have been identified as a challenge to safe and efficient maritime operations. A reason behind the issues is the lack of guidance from regulatory agencies, particularly regarding interface design. The International Maritime Organisation (IMO) has taken measures to address the situation, an example of which is the development of Circular MSC.1/Circ.1609 Guidelines for the Standardisation of User Interface Design for Navigation Equipment. This article presents a case study on the development of MSC.1/Circ.1609. An in-depth analysis was conducted using multiple sources of data to identify influential factors behind key events and provide recommendations for similar future initiatives. The data used in the study include interviews with major stakeholders, official reports of the development work, and personal records of members of the development team. The study finds the development of MSC.1/Circ.1609 to be affected by the politics of decision-making at the IMO, the difficulties associated with developing implementable technical regulations, and the rigid nature of IMO working procedures. The findings suggest that successful human factors regulations should address the requirements of both end-users and implementors, which are equipment manufacturers in this case. This study also identifies characteristics of IMO working principles that should be considered to improve the application of human factors in the maritime field.
The Short Local Algebras of Dimension 6 with Non-projective Reflexive Modules
Authors: Ringel Claus Michael 
Published: May 2023

AbstractLet A be a finite-dimensional local algebra over an algebraically closed field, let J be the radical of A. The modules we are interested in are the finitely generated left A-modules. Projective modules are always reflexive, and an algebra is self-injective iff all modules are reflexive. We discuss the existence of non-projective reflexive modules in case A is not self-injective. We assume that A is short (this means that $$ J^3 = 0$$

J
3

=
0

). In a joint paper with Zhang Pu, it has been shown that 6 is the smallest possible dimension of A that can occur and that in this case the following conditions have to be satisfied: $$ J^2$$

J
2

is both the left socle and the right socle of A and there is no uniform ideal of length 3. The present paper is devoted to showing the converse.
A prediction tool for maintenance costs estimation during the design process of a ship engine room
Authors: Gualeni Paola , Vairo Tomaso 
Published: May 2023

AbstractWhen dealing with maintenance in ships engine room, the space available around machinery and systems (clearance) plays an important role and may significantly affect the cost of the maintenance intervention. In a first part of a current research study Gualeni et al. (Ship Technol Res, 10.1080/09377255.2021.2020949, 2022), a quantitative relation between the maintenance costs increment due to the clearance reduction is determined, using a Bayesian approach to General Linear Model (GLM), with reference to a single item/component of a larger system Sánchez-Herguedas et al. (Reliability Eng Syst Saf 207: 107394, 2021). This paper represents the second part of the activity and it enforces a systemic view over the whole machinery or system Sanders and Klein (Proc Comput Sci 8:413–419, 2012). The aim is to identify not only the relation between maintenance costs and clearance reduction, but also how the clearance reductions of the single components/items interact and affect the whole system/machinery accessibility and maintainability, meant as relevant emerging properties.The system emerging properties are investigated through the design and application of a Hidden Markov Model Salvatier et al. (Peer J Comput Sci 2: e55, 2016); i.e., the system is modeled by a Markov process with unobservable states. The sequence of states is the maintainability of the system (which incorporates each one of the single components) while the evidence is the increase in cost of maintenance related to the space reduction.By predicting a sequence of states, it is therefore possible to predict the interactions between the system components clearances and determine how the emerging maintainability property is affected by the engine room design.
Generation of Textured Surfaces by Vibration-Assisted Ball-End Milling
Authors: Yuan Yanjie , Yu Kunkun , Zhang Chen , Chen Qi , Yang Weixiang 
Published: May 2023

AbstractTextured surfaces have been widely applied in many fields due to their excellent functional performances. Although several micro-scale surface texturing techniques have been used to fabricate surface textures, most are either very expensive, have material limitations, or lack flexibility. In this study, a novel textured surface generation method using vibration-assisted ball-end milling with a non-resonant vibrator is proposed. Firstly, the configuration of the vibration-assisted ball-end milling system is introduced. Then, the trajectories of the cutting edges are modeled and analyzed. Furthermore, an analysis of a non-resonant vibrator is conducted. Finally, surface texture machining experiments are conducted, and the feasibility of the proposed vibration-assisted ball-end milling method for surface texture fabrication is verified.
Anomaly-based intrusion detection system for IoT application
Authors: Bhavsar Mansi , Roy Kaushik , Kelly John , Olusola Odeyomi 
Published: May 2023

AbstractInternet-of-Things (IoT) connects various physical objects through the Internet and it has a wide application, such as in transportation, military, healthcare, agriculture, and many more. Those applications are increasingly popular because they address real-time problems. In contrast, the use of transmission and communication protocols has raised serious security concerns for IoT devices, and traditional methods such as signature and rule-based methods are inefficient for securing these devices. Hence, identifying network traffic behavior and mitigating cyber attacks are important in IoT to provide guaranteed network security. Therefore, we develop an Intrusion Detection System (IDS) based on a deep learning model called Pearson-Correlation Coefficient - Convolutional Neural Networks (PCC-CNN) to detect network anomalies. The PCC-CNN model combines the important features obtained from the linear-based extractions followed by the Convolutional Neural Network. It performs a binary classification for anomaly detection and also a multiclass classification for various types of attacks. The model is evaluated on three publicly available datasets: NSL-KDD, CICIDS-2017, and IOTID20. We first train and test five different (Logistic Regression, Linear Discriminant Analysis, K Nearest Neighbour, Classification and Regression Tree,& Support Vector Machine) PCC-based Machine Learning models to evaluate the model performance. We achieve the best similar accuracy from the KNN and CART model of 98%, 99%, and 98%, respectively, on the three datasets. On the other hand, we achieve a promising performance with a better detection accuracy of 99.89% and with a low misclassification rate of 0.001 with our proposed PCC-CNN model. The integrated model is promising, with a misclassification rate (or False alarm rate) of 0.02, 0.02, and 0.00 with Binary and Multiclass intrusion detection classifiers. Finally, we compare and discuss our PCC-CNN model in comparison to five traditional PCC-ML models. Our proposed Deep Learning (DL)-based IDS outperforms traditional methods.
Anthropogenic fine aerosol and black carbon distribution over urban environment
Authors: Sankar Tapan Kumar , Ambade Balram , Mahato Dilip Kumar , Kumar Amit , Jangde Rajendra 
Published: May 2023

AbstractReal-time black carbon (BC) and fine particulate matter (PM) were collected from January to December 2017 with a portable Aethalometer and air sampler in the urban environment of Jamshedpur, India. In the present study, the diurnal and seasonal variations of BC and meteorological variables were analysed. The diurnal variation of BC ranged from 2.1 to 15.5 gm-3, with the lowest concentration during the monsoon season and the highest during the winter season, because in monsoon most of the BC and PM are settled down. The annual mean BC mass concentration was observed at 6.22 ± 3.95 µgm−3. While, fine PM2.5 varied from 41.6 to 260.3 µgm-3, with an annual mean of 97.49 ± 63.52 µgm−3. During monsoon, the BC mass concentration shows a value of ˂ 3 µgm−3. Additionally, the percentage contribution of BC in PM2.5 was determined to be around 5.06% (winter), 6.32% (summer), 5.20% (monsoon), and 7.21% (post-monsoon). The change in BC concerning different meteorological parameters was systematically studied, in which an exciting inverse relationship was noticed between BC concentration and temperature. The correlation between BC and wind speed was also established as a negative connection during study periods. It also observed a negative correlation with precipitation. Finally, the air back trajectory was analysed using the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT), which revealed that the essential campaign of aerosol-bounded air parcels was mostly coming from the western part of India, with some marine air masses also joining from the Bay of Bengal during summer and post-monsoon. Overall study shows that highest BC and PM2.5 was observed in the winter season because of mixed layer height (MLH).
Response of hypersonic compression corner flow to upstream disturbances
Authors: Hao Jiaao , Cao Shibin , Guo Peixu , Wen Chih-Yung 
Published: May 2023

Hypersonic flow over a two-dimensional compression corner is investigated using computational fluid dynamics and global resolvent analysis in this study, which is a continuation of the work done by Hao et al. (J. Fluid Mech., vol. 919, 2021, p. A4). The same baseline free-stream conditions with a Mach number of 7.7 and a unit Reynolds number of 4.2 × 106 m−1 are considered. The ramp angles range from 0° (equivalent to a flat plate) to 12° (slightly below the critical angle of global instability). During this process, the base flow evolves from no separation to incipient separation to large separation. The resolvent analysis reveals that the optimal response to upstream disturbances localised near the leading edge is in the form of steady streamwise streaks for all interaction strengths, which arise from transient growth in the flat-plate boundary layer due to the lift-up mechanism and significantly grow near the corner due to the Görtler instability. The most amplified spanwise wavelength decreases as the ramp angle is increased and scales with the incoming boundary-layer thickness.
Theches: an elusive mountain
Authors: Brennan Shane G. , Tuplin Christopher J. 
Published: May 2023

AbstractThis article deals with the location of Mount Theches, the vantage point from which Xenophon’s Ten Thousand famously got their first sight of the sea after a long and arduous march across eastern Anatolia. It discusses what the written sources can and cannot tell us about this iconic spot, comments on the currently favoured identification (stressing its dependence on an assumption about the route the army followed to and from the vantage point), and presents three other places that can come into contention if different assumptions are made about the route. The aim is not to insist that one or other of these is the correct solution but rather to underline the point that, since we do not (and are never likely to) know how the Ten Thousand approached Theches, and since there are many points in the Pontic Mountains behind Trabzon from which the sea can be glimpsed in the far distance, the identity of Theches is a problem that does not admit of more than conjectural solution. This prompts broader reflections on the textual and the topographical, and the relationship between landscape and narrative.
The episcopal palace of Parnassos in Cappadocia and its Early Byzantine floor mosaics
Authors: Arslan Melih , Niewöhner Philipp , Yeğin Yavuz 
Published: May 2023

AbstractThe Roman mansio or way station and Byzantine bishopric of Parnassos in Cappadocia is chiefly known through inscriptions and bishops’ lists and identified with the small Turkish village of Parlasan/Değirmenyolu. It came as a surprise when a salvage excavation unearthed a large building with sumptuous floor mosaics beyond the outskirts of the village. Previous excavation reports misrepresented the building as a basilica church, when it was in fact an apsed hall and may be identified as the reception unit of an elite residence, as this article shows. A large central room had an elevated apse where the landlord would have sat. An animal mosaic in front of the apse is comparable to similar compositions in fourth-to-sixth-century urban palaces but avoids any reference to pagan mythology and employs stylistic features that are otherwise known from church floors. A mosaic inscription identifies the reception unit as belonging to the bishop and thus as part of the episcopal palace. This discovery is augmented by the find of a Late Roman sarcophagus and three Early Christian gravestones. Later, after the original palace was mostly destroyed, the building complex underwent a second, utilitarian phase that appears to date from the Invasion Period, when the Arabs raided central Anatolia from the seventh to ninth centuries.
Spectral Classification of Comets
Authors: Bouska J. 
Published: May 2023

AbstractUp to now a few hundred of spectra of several tens of comets have been obtained at different observatories over the whole world. On the one hand, there are high dispersion spectra photographed with slit spectrographs attached to large telescopes, and on the other, small dispersion spectra obtained by means of objective prisms. These objective prism spectra, showing the principal emission bands only, are known for a considerable number of comets, and its appearance is usually described verbally.
Mission Strategy for Cometary Exploration in the 1980’s
Authors: Farquhar Robert W. 
Published: May 2023

Ballistic intercept missions to comets have been strongly endorsed as the best way to initiate a program of cometary exploration (Roberts, 1971). This mission mode is the simplest and least expensive, and can provide a large science return. Currently, a near-perihelion intercept of Encke’s comet in 1980 is receiving serious consideration for the initial cometary mission. Assuming that the 1980 Encke mission will be carried out as planned, a question that should be considered is: what is the next logical step in an evolutionary sequence of cometary missions? Two possibilities are:
Investigate a particular comet in detail. That is, perform a rendezvous mission.Study the physical characteristics of several types of comets. This goal could be achieved by carrying out a series of intercept missions to comets that have exhibited diverse behavior.
Right to Roam? Nineteenth-Century Commons and Caroline Lesjak's The Afterlives of Enclosure
Authors: Livesey Ruth 
Published: May 2023

It is August 2022, and I am sitting in the British Library completing a shamefully late review (this one) when I see the headline: “Trespassers Demand Right to Roam Minister's 12,000 Acre Estate.” One hundred fifty protesters led by activist Nadia Shaikh and complete with a Morris dancing troupe walked into the Englefield estate of Richard Benyon, the UK government minister responsible for access to nature, as part of a campaign around public access to land. Benyon's ancestral estate contains sizeable areas of former common land enclosed by his ancestor, also Richard Benyon, in 1802. Nick Hayes, author of The Book of Trespass, who was at the protest, added:
Over the next twenty years [Richard Benyon] moved an entire village out of sight of Englefield house to make way for his deer park. Then, in 1854, a stopping order was granted by his friends in parliament to close the public road that ran in front of his house. Today the Ramblers’ “Don't Lose Your Way” website reveals a former footpath running through the estate, identifiable on old Ordnance Survey maps, but which has since been extinguished.Like many other activists over the past three hundred years or more, Shaikh organized a walking—and singing and dancing—resistance to the legal fact of enclosure that leaves only 8 percent of English land with free access. As Raymond Williams reminded readers in The Country and the City (1973), the “mathematical grids of enclosure awards, with their straight hedges and straight roads, are contemporary with the natural curves and scattering of the park scenery.”
Harnessing potential of maize (Zea mays) genetic resources for exploring yield and yield-related traits under organic farming in hill region
Authors: Kapoor Chandan , Singh Shweta , Avasthe R. K. , Sankar S Mukesh , Pattanayak A. , Raj Chandramani , Singh Matber 
Published: May 2023

AbstractTo explore trait variation, assess relative performance and establish association among yield and its associated traits in maize under organic system, 373 maize genotypes that consisted of landraces, open-pollinated varieties and single-cross hybrids were tested under organic management in Sikkim midhills. Data of 8 years (2009–2015 and 2019) for 12 agronomic traits viz., plant height, days to 50% tasselling, days to 50% silking, days to 75% dry husk, grain yield per ha, anthesis–silking interval, cob length, cob diameter, kernel rows per cob, kernels per row, number of cobs per plot and test weight were taken for analysis. Conventionally bred maize hybrids yielded 95.36% higher than the landraces and 58.60% higher than the open-pollinated varieties. Landraces displayed highest mean anthesis–silking interval of 7.18 days. In open-pollinated varieties, test weight showed a positive association with grain yield (0.37) while plant height (0.33) and kernels per row (0.34) were positively correlated to grain yield in case of landraces. Number of cobs per plot showed a very strong association with grain yield in hybrids (1.0). Kernels per cob and test weight contributed 24% to the variation in grain yield in open-pollinated varieties while anthesis–silking interval, days to maturity, number of cobs/plot, test weight and kernel per row accounted for 97% of the variation in grain yield in landraces. Grain yield in single-cross hybrids is contributed maximum (97%) by days to tasselling, silking, anthesis–silking interval, plant height and number of cobs per plot. The study indicates attaining high number of cobs per unit area along with emphasis on traits such as kernels per row, cob length and diameter for achieving higher yields in single-cross hybrids, selection of high test weight genotypes for open-pollinated varieties and emphasis on cob length, kernels per row and plant height for yield improvement in landraces.
Full‐Waveform Tomography of the African Plate Using Dynamic Mini‐Batches
Authors: van Herwaarden Dirk‐Philip , Thrastarson Solvi , Hapla Vaclav , Afanasiev Michael , Trampert Jeannot , Fichtner Andreas 
Published: May 2023

AbstractWe present a seismic model of the Africa Plate, constructed with the technique of full‐waveform inversion. The purpose of our model is to serve as a foundation for quantitative geodynamic and geochemical interpretation, earthquake‐induced ground motion predictions, and earthquake source inversion. Starting from the first‐generation Collaborative Seismic Earth Model, we invert seismograms filtered to a minimum period of 35 s and compute gradients of the misfit function with respect to the model parameters using the adjoint state method. We use dynamically changing mini‐batches of the complete data set to compute approximate gradients at each iteration. This approach has three significant advantages: (a) it reduces computational costs for model updates and the inversion, (b) it enables the use of larger datasets without increasing iteration costs, and (c) it makes it trivial to assimilate new data since we can extend the data set without changing the misfit function. We invert data from 397 unique earthquakes and 184,356 unique source‐receiver pairs. We clearly image tectonic features such as the Afar triple junction and low‐velocity zones below the Hoggar, Aïr, and Tibesti Mountains, pronounced more than in earlier works. Finally, we introduce a new strategy to assess model uncertainty. We deliberately perturb the final model, perform additional mini‐batch iterations, and compare the result with the original final model. This test uses actual seismic data instead of artificially generated synthetic data and requires no assumptions about the linearity of the inverse problem.
High‐Frequency Variability Induced in the Southern California Bight by a Wind Event in Sebastián Vizcaíno Bay, Baja California
Authors: Ramos‐Musalem K. , Gille S. T. , Cornuelle B. D. , Mazloff M. R. 
Published: May 2023

AbstractAlthough the California Current System extends as far south as the southern tip of the Baja California Peninsula (BCP), some past model domains have employed an open boundary near the Mexico‐US border, excluding Sebastián Vizcaíno Bay (SVB), a hook‐like coastal feature at mid‐length of the BCP. An earlier modeling study has shown the SVB to be a previously unknown forcing region that governs SSH variability in the Southern California Bight (SCB). Motivated by that evidence, our aim is to understand the variability that originates from the SVB and to identify what is lost in a numerical model of the SCB when the SVB is excluded. To do this we use an idealized configuration of the MITgcm, without tides, using the bathymetry with the bay and comparing it to model runs where the bay is removed. Our results show that a short wind event (≤4 hr) blowing over SVB can enhance variability everywhere in the domain. First, the event excites a seiche in the bay at frequency 5.2 cpd. Then, seiche energy leaks into the domain in the form of gravity waves that are topographically amplified in the SCB, coastal trapped waves (CTWs) that travel north along the coast, and internal waves, that enhance vertical velocity variance at particular depths by up to 27% compared to experiments without the SVB. Given the frequency of wind events like the one modeled, our results suggest that the SVB is a continuous source of gravity waves, internal waves, and CTWs to the SCB.