bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in scleroderma-related interstitial lung disease and its association with respiratory clinical parameters
Authors: Ponniah Thayalan , Wong Chee Kuan , Ng Choung Min , Raja Jasmin 
Published: February 2025

Objectives: Interstitial lung disease in systemic sclerosis has a significant impact in the quality of life. This prospective study was designed to determine the correlation between quality of life in systemic sclerosis-interstitial lung disease patients using patient-reported outcome measures and the lung function test parameters, with assessment done at baseline and 1 year. Methods: In total, 63 consecutive systemic sclerosis-interstitial lung disease patients underwent lung function test, 6-minute walk distance, and quality of life–validated questionnaires (King’s Brief Interstitial Lung Disease and Functional Assessment of Chronic Illness Therapy dyspnea). King’s Brief Interstitial Lung Disease covers three components, namely chest, breathlessness, and psychological symptoms. The Functional Assessment of Chronic Illness Therapy dyspnea score has Part I (breathlessness symptoms) and Part II (physical limitation due to breathlessness). All assessments except for 6-minute walk distance were done both at baseline and at 12 months. Results: Both forced vital capacity predicted percentage at baseline and 12 months had significant negative correlation with the Functional Assessment of Chronic Illness Therapy dyspnea score Part I ( p values: 0.038 and <0.001, respectively). Both forced vital capacity and diffuse capacity for carbon monoxide predicted percentage at 12 months were also negatively correlated with Functional Assessment of Chronic Illness Therapy dyspnea score Part II ( p values: 0.001 and 0.010, respectively). There was no significant correlation between King’s Brief Interstitial Lung Disease score and the lung function parameters, at both baseline and at 1-year interval. Positive significant correlation was observed between forced vital capacity predicted percentage at baseline and 6-minute walk distance ( p = 0.001). Conclusion: Systemic sclerosis-interstitial lung disease affects quality of life, which is best assessed using the Functional Assessment of Chronic Illness Therapy dyspnea score as it correlates significantly with the lung function test parameters.
Exploring men’s cancer journeys in Norway: a comprehensive survey on diet, supplements, and use of complementary and alternative therapies
Authors: Kristoffersen Agnete E. , Nakandi Kiwumulo , Norheim Arne Johan , Bjelland Mona , Nilsen Jorunn V. , Ben-Arye Eran 
Published: February 2025

Abstract

Background
Each year, over 20,000 men are diagnosed with cancer in Norway, and approximately 150,000 men who have previously been diagnosed with cancer are currently alive. Many of these cancer survivors encounter a range of challenges, including fatigue, sexual dysfunction, urinary issues, and pain, all of which can significantly impact their quality of life. Consequently, a substantial number of men seek support beyond conventional healthcare. This study aims to investigate the motivations behind the use of Complementary and Alternative Medicine (CAM) and dietary changes/supplements in men with cancer in Norway, and further explore their communication with healthcare providers, self-reported effects and adverse effects, and the sources of information they rely on regarding these practices.

Method
In collaboration with the Norwegian Cancer Society (NCS), we conducted an online cross-sectional study involving participants of their user panel who have current or past experiences with cancer (n = 706), of whom 218 identified as men. The study was conducted during the autumn of 2021, employing a modified cancer-specific version of the International Questionnaire to Measure Use of Complementary and Alternative Medicine (I-CAM-Q). A total of 153 men agreed to participate, yielding a response rate of 70%.

Results
A large proportion of the respondents used CAM (62%), dietary supplements (65%), and/or adjusted their diet (81%) to boost their immune systems and increase their quality of life. The dietary adjustments involved eating more fruits, vegetables, fish, and whole grains. Many participants also used relaxation techniques and visited CAM providers to enhance quality of life. Most participants reported better health outcomes as a result of these interventions. The Internet and healthcare professionals were the main source of information, although many did not disclose their dietary changes and CAM therapy use with healthcare professionals.

Conclusion
By leveraging these insights, healthcare providers, policymakers, and researchers can collectively work towards a more holistic and patient-centred approach to cancer care, ultimately improving the overall well-being and quality of life for male cancer survivors.
Consumer and community involvement: implementation research for impact (CCIRI) – implementing evidence-based patient and public involvement across health and medical research in Australia – a mixed methods protocol
Authors: Ng Ashley H. , Reeder Sandra , Jones Angela , Cahill Ainslie , Langridge Debra , Baker Susanne , Heiss Leah , Dorin Alan , Teede Helena 
Published: February 2025

Abstract

Background
Within Australia, there is increasing recognition of the importance and value of patient and public involvement, or consumer and community involvement (CCI), in health and medical research and healthcare improvement. Despite this and policy mandates, there has been little behavioural and systems change to embed and support CCI. Often, this is relegated to tokenistic gestures rather than authentic partnerships. The aim of this national project is to use evidence-generated knowledge co-led by consumers, community members, researchers and clinicians to embed CCI in health and medical research and healthcare improvement.

Methods
The Consolidated Framework for Implementation Research and the Learning Health System framework underpin the project to facilitate an iterative process to change systems and individual behaviour towards adoption of CCI in health and medical research and healthcare improvement. Key stakeholder groups include research translation centres, funding bodies, clinicians, professional staff involved in healthcare improvement, researchers and consumers and community members. To understand the attitudes, knowledge, beliefs, behaviours, system barriers and facilitators around CCI in health and medical research and healthcare improvement, semi-structured interviews and surveys will be conducted across key stakeholder groups. Template analysis and descriptive statistics will be used to report data from the national survey respectively prior to triangulation of data. Findings will be reported through traditional scientific outputs such as conference presentations and peer-reviewed publications. Other anticipated outputs include policy briefs, organizational implementation toolkits and resources and a co-designed digital knowledge hub to support individuals with implementation and scale up across stakeholders.

Discussion
This study will build on considerable stakeholder engagement and prior priority-setting and includes broad and detailed consideration of perspectives from diverse stakeholders at a national level. Robust methodological frameworks, co-design and partnership with stakeholders will be used to inform resources to support systems change to facilitate CCI in health and medical research and healthcare improvement. Ethics approval was obtained from Monash Health (RES-23–0000-275Q).
Aquaporins modulate the cold response of Haemaphysalis longicornis via changes in gene and protein expression of fatty acids
Authors: Wang Han , Bai Ruwei , Pei Tingwei , Meng Jianglei , Nwanade Chuks F. , Zhang Yuchao , Liang Xiujie , Tang Yunsheng , Liu Jingze , Yu Zhijun 
Published: February 2025

Abstract

Background
As ectotherms that spend most of their life in the environment (off-host), ticks face challenges in maintaining water balance, and some species must cope with severe low winter temperatures. Aquaporins (AQPs) are essential membrane proteins that enhance cold tolerance in many animals by regulating homeostatic processes. However, the dynamic expressions and involvement of aquaporins in the cold stress of ticks remain unclear.

Methods
In the present study, three AQP genes, HlAQP2, HlAQP3, and HlAQP5, belonging to the major intrinsic protein (MIP) superfamily, were characterized from the important vector tick Haemaphysalis longicornis. Then, multiple bioinformatics analyses were performed. Quantitative real-time PCR (qPCR) was used to detect different expressions of H. longicornis genes under different cold treatment conditions. RNA interference was used to explore the relationship between AQP and the cold response of H. longicornis. Additionally, proteomic and transcriptomic analyses were used to investigate the mechanisms underlying the effects of AQPs on cold response in ticks.

Results
The amino acid sequence of AQPs shows high homology in Ixodida, with HlAQP2 and HlAQP5 proteins comprising two asparagine-proline-alanine (NPA) motifs, whereas HlAQP3 protein was featured by glycerol facilitator GlpF channel. The spatiotemporal expression of AQPs in H. longicornis varied significantly after low temperature treatment, and different expression patterns were observed over prolonged exposure periods. RNAi knockdown of AQPs significantly increased tick mortality after treatment at a sublethal temperature of − 14 °C for 2 h. Proteomic and transcriptomic analysis revealed that the differentially expressed genes and proteins caused by the knockdown of AQPs are mainly enriched in the fatty acid metabolism pathway.

Conclusions
The above results indicated that AQPs could regulate tick cold response by modulating water balance and fatty acid metabolism.

Graphical Abstract
Sex differences in romantic love: an evolutionary perspective
Authors: Bode Adam , Luoto Severi , Kavanagh Phillip S. 
Published: February 2025

Abstract

Background
Evolutionary selection pressures, most notably sexual selection, have created (and continue to sustain) many psychobehavioral differences between females and males. One such domain where psychobehavioral sex differences may be prominent is romantic love. The ways in which females and males may experience and express romantic love differently has been studied in psychology as well as in the arts down the ages; however, no studies have focused specifically on romantic love (i.e., passionate love) using validated measures of romantic love solely in people who are currently experiencing this form of love.

Methods
This study investigated sex differences in features and aspects of romantic love among 808 young adults experiencing romantic love. Univariate and multivariate analyses were conducted to measure sex differences in the number of times participants had fallen in love, when they fell in love relative to when they started their romantic relationship (love progression), intensity of romantic love, obsessive thinking about a loved one, and commitment. Additional univariate comparisons were made for sex differences in Passionate Love Scale scores.

Results
Univariate analyses showed that males had fallen in love a greater number of times than females. Males had also fallen in love more quickly than females. Females had higher intensity of romantic love, higher commitment, and higher obsessive thinking about a loved one than males. These findings remained robust in multivariate analyses, controlling for several variables believed to influence romantic love, with the exception of commitment, which was no longer significant when other variables were controlled for.

Conclusions
The findings are considered with reference to the evolutionary theory of sexual selection. We suggest that the specific adaptive challenges faced by females and males in the evolutionary history of romantic love may contribute to sex differences in romantic love. The findings shed light on contemporary sex differences in romantic love, as well as the possible evolutionary history and evolutionary functions of romantic love.
Malic enzyme 3 mediated the effects of malic acid on intestinal redox status and feed efficiency in broilers
Authors: Jiang Hongfeng , Li Genghui , Yang Xue , Feng Xiaohua , Li Penglin , Yang Huisi , Cai Demin , Jiang Qingyan , Shu Gang 
Published: February 2025

Abstract

Background
Intestinal oxidative stress serves as an endogenous host defense against the gut microbiota by increasing energy expenditure and therefore decreasing feed efficiency (FE). Several systems coordinately regulate redox balance, including the mitochondrial respiratory chain, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and different antioxidants. However, it remains unclear which redox balance compartments in the intestine are crucial for determining FE.

Results
In this study, we first screened the key targets of different metabolites and redox balance-related gene expression in broiler ceca. We then constructed a mouse colitis model to explore malic acid (MA) ability to alleviate intestinal inflammation. We further used controlled release technology to coat MA and investigated its effects on the intestinal redox status and FE in vivo. Finally, we examined the underlying mechanism by which MA modulated redox status using a porcine intestinal epithelial cell jejunum 2 (IPEC-J2) cell model in vitro. Our results demonstrated that the MA/malic enzyme 3 (ME3) pathway may play an important role in reducing oxidative stress in the broiler cecum. In addition, colon infusion of MA attenuated inflammatory phenotypes in the dextran sulfate sodium salt (DSS) induced mouse colitis model. Then, dietary supplementation with controlled-release MA pellet (MAP) reduced the feed to gain (F/G) ratio and promoted chicken growth, with reduced oxidative stress and increased bacterial diversity. Finally, the in vitro IPEC-J2 cell model revealed that ME3 mediated the effect of MA on cellular oxidative stress.

Conclusion
In summary, our study firstly revealed the important role of the MA/ME3 system in the hindgut of broiler chickens for improving intestinal health and FE, which may also be crucial for the implications of colon inflammation associated diseases.
Using human, social, structural, and positive psychological capital to explore science and mathematics teacher retention
Authors: Ekmekci Adem , Aqazade Mahtob , McGraw Rebecca , Rushton Gregory , Gibson David J. , Cerosaletti Cathleen , Daley Michael , Kucuk Burak 
Published: February 2025

Abstract

Background
Teacher turnover is a dire and chronic problem for many education systems across the globe. According to UNESCO, 70% of teachers will be replaced by 2030. This study investigates the relationship between the retention of science and mathematics teachers and factors related to human, social, structural, and positive psychological capital—a four-capital teacher retention model. More specifically, this study explores how teaching self-efficacy, leadership engagement, teacher-school fit, diversity beliefs, community connections, and professional social network characteristics (e.g., size, bridging, proximity, reach) relate to teacher retention. Additionally, potential differences in retention and the aforementioned factors related to the four-capital model between Master Teaching Fellows (MTFs) and their peers (non-MTFs) with similar human capital (demographics and experience) are explored in this study. Participants were K-12 science and mathematics teachers (85 MTFs and 82 non-MTFs) from six different regions across the U.S. MTFs participated in one of seven long-term (5–6 years) Robert Noyce Master Teaching Fellowship Programs funded by the National Science Foundation.

Results
Leadership engagement was positively associated with shifting (from teaching to a formal leadership position). Teacher-school fit was negatively associated with leaving. For secondary teachers, teaching self-efficacy was positively associated with shifting to a leadership position. Leadership network size, bridging, and geographic proximity variables were positively related to shifting when compared to staying as classroom teachers. Teaching network bridging and leadership network bridging were positively related to leavers when compared to stayers. MTF shifters were likely to shift earlier in their careers than non-MTFs. Lastly, MTFs had higher self-efficacy, geographically larger teaching networks and leadership networks, and more contacts and bridging roles in their leadership networks than non-MTFs.

Conclusion
Findings provide support for teacher leadership programs in promoting leadership roles and responsibilities for STEM teachers and retaining teachers in STEM education either in the classroom or in administrative roles. These findings suggest that school administrators may also play a key role in encouraging teachers to engage in leadership activities and have a broader impact on public education by, for example, adopting a hybrid model of leadership roles that involves classroom teaching.
Forecasting cryptocurrency volatility: a novel framework based on the evolving multiscale graph neural network
Authors: Zhou Yang , Xie Chi , Wang Gang-Jin , Gong Jue , Zhu You 
Published: February 2025

Abstract
Cryptocurrency is a remarkable financial innovation that has affected the financial system in fundamental ways. Its increasingly complex interactions with the conventional financial market make precisely forecasting its volatility increasingly challenging. To this end, we propose a novel framework based on the evolving multiscale graph neural network (EMGNN). Specifically, we embed a graph that depicts the interactions between the cryptocurrency and conventional financial markets into the predictive process. Furthermore, we employ hierarchical evolving graph structure learners to model the dynamic and scale-specific interactions. We also evaluate our framework’s robustness and discuss its interpretability by extracting the learned graph structure. The empirical results show that (i) cryptocurrency volatility is not isolated from the conventional market, and the embedded graph can provide effective information for prediction; (ii) the EMGNN-based forecasting framework generally yields outstanding and robust performance in terms of multiple volatility estimators, cryptocurrency samples, forecasting horizons, and evaluation criteria; and (iii) the graph structure in the predictive process varies over time and scales and is well captured by our framework. Overall, our work provides new insights into risk management for market participants and into policy formulation for authorities.
Biochemical and histopathological effects of clove oil on the land snail Helix aspersa
Authors: Abdel-Azeem Hoda H. 
Published: February 2025

Abstract

Background
Terrestrial snails are regarded as agricultural pests since they devour any plant components and cause financial and crop loss. This study aims to evaluate the antifeedant efficacy of clove oil on the snail Helix aspersa.

Results
The toxicity of clove oil was determined after 1 day of exposure. LC50 and LC90 values (%) were 9.8 and 16.03, respectively. Exposure to different concentrations of clove oil significantly (P ≤ 0.001) reduced protease activity and α-glucosidase activity in the digestive tract of Helix aspersa. The most decrease in protease activity is after the 1st week of exposure (32 ± 1 µmole/min/mg protein) at the concentration 4.5% clove oil. There is a significant decline in α-glucosidase concentration (27.9 ± 0.05 in 1st week and 30.6 ± 0.5 in the 3rd week (P ≤ 0.01) at the 4.5% clove oil. ALT, AST, and GTG were increased in both concentrations at the time beginning of exposure. ALT showed a significant elevation (P ≤ 0.01) to be 14.5 ± 0.5 and 22.9 ± 0; the values of AST were 54.9 ± 0.1 and 72 ± 0.2; GGT concentration was 134 ± 1 and 146 ± 0.5 at the concentrations 2% and 4.5% clove oil, respectively. Exposure to the clove oil at different concentrations caused abnormal changes in the digestive gland and intestine such as vacuolation of cells, gaps, and degeneration in the mucosa. Ultrastructural abnormalities such as degeneration of microvilli, different sizes of electron-dense vesicles, and lysosomes were observed upon exposure to clove oil.

Conclusion
So, clove oil can be used as an effective bio-molluscicide.
lncRNA FLVCR1-AS1 sponges miR-381-3p and promotes Wnt signaling pathway resulting in colorectal cancer progression
Authors: Ahmadi Beni Faeze , Abdolvand Mohammad , poorbafrani Fariborz , Salehi Mansoor , Dehghanian Fariba , Kazemi Mohammad 
Published: February 2025

Abstract

Background
Colorectal cancer (CRC) is the third most frequent cancer and the second deadliest cancer, worldwide. Long noncoding RNAs (lncRNAs) have been introduced as crucial regulators of CRC. lncRNA feline leukemia virus subgroup C receptor 1 antisense RNA 1 (FLVCR1‑AS1) is suggested to play a significant role in the tumorigenesis of several cancers. The Wnt signaling pathway is the most deregulated pathway in CRC.

Objective
The present study aimed to investigate the underlying mechanism of function of FLVCR1-AS1 in CRC through FLVCR1-AS1/miR-381-3p/CTNNB1, LRP6, and FZD3 axis.

Methods
The expression levels of FLVCR1-AS1 were analyzed in colorectal cancer (CRC) tissues compared to adjacent normal tissues, as well as across various CRC cell lines. In HCT116 cells, FLVCR1-AS1 was knocked down, and the subsequent effects on the expression levels of FLVCR1-AS1, miR-381-3p, and three genes were measured using real-time PCR. Proliferation differences were assessed through an MTT assay, while cell death was evaluated using flow cytometry.

Results
The results confirmed that FLVCR1-AS1 was upregulated in CRC tissues compared to adjacent normal tissues. RT-qPCR validated that FLVCR1-AS1 has the most level of expression in HT29, HCT116, SW480, and Caco2; respectively. Knockdown of FLVCR1‑AS1 was significantly followed by attenuated viability of HCT116 cells; while resulted in enhancement of apoptosis and necrosis.

Conclusion
These findings support the idea that FLVCR1-AS1 may act as an oncogene in CRC, and targeting FLVCR1-AS1/miR-381-3p/CTNNB1, LRP6, and FZD3 axis may be introduced as a novel target for CRC therapy and diagnosis in the future.
Artificial intelligence-driven distributed acoustic sensing technology and engineering application
Authors: Shao Liyang , Zhang Jingming , Chen Xingwei , Xu Deyu , Gu Huaxin , Mu Qi , Yu Feihong , Liu Shuaiqi , Shi Xiaobing , Sun Jiayao , Huang Zixing , Yang Xiongji , Zhang Haifeng , Ma Yunbin , Lu Han , Liu Chuanqing , Yu Changyuan 
Published: February 2025

Abstract
Distributed acoustic sensing (DAS) technology is a fiber-optic based distributed sensing technology. It achieves real-time monitoring of acoustic signals by detecting weak disturbances along the fiber. It has advantages such as long measurement distance, high spatial resolution and large dynamic range. Artificial intelligence (AI) has great application potential in DAS technology, including data augmentation, preprocessing and classification and recognition of acoustic events. By introducing AI algorithms, DAS system can process massive data more automatically and intelligently. Through data analysis and prediction, AI-enabled DAS technology has wide applications in fields such as transportation, energy and security due to its accuracy of monitoring data and reliability of intelligent decision-making. In the future, the continuous advancement of AI technology will bring greater breakthroughs and innovations for the engineering application of DAS technology, play a more important role in various fields, and promote the innovation and development of the industry.