bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faire participer pour faire accepter ? Cadrages du débat et cultures épistémiques en tension dans une recherche participative
Authors: Seguin Laura 
Published: May 2023

Dans les sciences de l’environnement, les recherches participatives conduites en partenariat avec des groupes socioprofessionnels peuvent répondre à des objectifs très différents. Les fondements sur lesquels ces recherches s’adossent, et notamment les partis pris épistémologiques et politiques propres aux chercheurs et chercheuses, à leurs partenaires et aux organismes de financement, déterminent le cadrage des espaces participatifs auxquels les parties prenantes sont ensuite conviées. Pourquoi faire participer, qui faire participer ? Quels savoirs mobiliser et/ou construire ? Dans une perspective de sociologie des sciences, cet article porte un regard réflexif sur un projet de recherche participative, en s’intéressant à sa genèse et en prenant les scientifiques et partenaires pilotes du projet comme objets de recherche. L’analyse met en évidence les opérations de (re)cadrage des termes du débat et des espaces participatifs. Elle montre également l’intérêt d’introduire un processus réflexif de la part des scientifiques qui interviennent sur le cours de l’action, dans un processus de co-ingénierie de la participation.
La fabrique participative de l’offre programmatique. Métamorphoses du « faire campagne » et dépolitisation de l’école dans la liste « Amiens c’est l’tien » aux élections municipales de 2020
Authors: Douniès Thomas 
Published: May 2023

L’article étudie ce que la métamorphose participative des campagnes politiques fait à la formation de l’offre programmatique à l’aune du traitement de l’école dans la liste d’union de la gauche « Amiens c’est l’tien » aux élections municipales françaises de 2020. L’approche ethnographique montre que la démocratisation de l’élaboration du programme se transforme en processus d’évaluation de la conflictualité des propositions. Le dispositif participatif contribue à une consensualisation du traitement de l’école obéissant à des finalités externes – travailler une présentation de soi de la liste qui soit non clivante – et des finalités internes – contourner les dissensus entre membres de la campagne. En éclairant les relations entre la transformation des pratiques de représentation, la recomposition de la division du travail politique, et les modalités de dépolitisation des enjeux sociaux, l’enquête montre en quoi le dispositif participatif est le laboratoire d’évolutions en cours du jeu politique et contribue ainsi à la compréhension des transformations contemporaines de la démocratie locale.
Le problème et la question
Authors: Esmili Hamza , Giry Johan 
Published: May 2023

L’article propose une relecture la controverse insécablement politique et épistémologique qui prend forme dans le problème musulman en France. Il retrace deux de ses motifs constitutifs : l’un libéral qui correspond au paradigme de la lutte contre la radicalisation, l’autre conservateur apparaissant avec la thèse du séparatisme islamiste. En creux de la dispute autour du problème musulman, il s’agit ensuite de retrouver le motif manquant – celui que l’on affirme socialiste – en vue d’appréhender autrement, de façon tout à fait sociologique, la réaffiliation religieuse parmi les immigrés et leurs enfants. Ce motif refoulé dans notre conscience collective est fondé sur l’appréhension du social comme dimension sui generis , irréductible tant à son identification libérale à une classe d’éléments reliés par l’analogie de propriétés sociales qu’à la réaction conservatrice déliant la nation des solidarités pratiques qui ne cessent pourtant de la parcourir. Intrinsèquement sociologique et politique, le motif socialiste se découvre en filigrane de la refondation réflexive qui prend forme dans le réinvestissement de la tradition islamique parmi les immigrés et leurs enfants.
Comparing Visual Outcomes of Light Adjustable Intraocular Lenses in Patients With and Without Prior History of Corneal Refractive Surgery
Authors: Moshirfar Majid , Henrie Marshall K. , Payne Carter J. , Hansen Annika M. , Ronquillo Yasmyne C. , Hoopes Phillip C. 
Published: May 2023

Purpose:
To assess visual outcomes of light adjustable intraocular lens (LAL; Calhoun Vision, Inc) implantation after cataract extraction in patients with a history of corneal refractive surgery.

Methods:
The records of patients who received LALs with and without a history of corneal refractive surgery were retrospectively reviewed. Data for 51 eyes (30 patients) with a history of corneal refractive surgery and 52 eyes (44 patients) without refractive surgery were analyzed. A total of 36 eyes of patients with and 43 eyes of patients without a history of corneal refractive surgery had 12-month follow-up data available. The primary outcomes evaluated were uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA).

Results:
At 12 months, 31% of eyes with a history of corneal refractive surgery had a UDVA of 20/20 or better and 97% of eyes were 20/40 or better. In contrast, 63% of patients with no history of corneal refractive surgery had 20/20 UDVA or better at 12 months and 100% were 20/40 or better. Of patients with a history of corneal refractive surgery, 55% and 83% of eyes at 12 months were within ±0.50 and ±1.00 diopters, respectively, of the target refraction compared to 89% and 96% of eyes without a history of corneal refractive surgery.

Conclusions:
LALs are a promising platform for achieving excellent visual outcomes following cataract surgery. Patients with a prior history of corneal refractive surgery can achieve excellent visual outcomes with the LAL. However, this study found that patients with a history of corneal refractive surgery demonstrated less predictable visual acuity outcomes when compared to patients without a history of corneal refractive surgery.

[
J Refract Surg.
2023;39(5):311–318.]
Characterization of Chemotaxis-Associated Gene Dysregulation in Myeloid Cell Populations in the Lungs during Lipopolysaccharide-Mediated Acute Lung Injury
Authors: Holloman Bryan Latrell , Cannon Alkeiver , Wilson Kiesha , Singh Narendra , Nagarkatti Mitzi , Nagarkatti Prakash 
Published: May 2023

Abstract
During endotoxin-induced acute lung injury (ALI), immune cell recruitment resulting from chemotaxis is mediated by CXC and CC chemokines and their receptors. In this study, we investigated the role of chemokines and their receptors in the regulation of myeloid cell populations in the circulation and the lungs of C57BL/6J mice exhibiting LPS-mediated ALI using single-cell RNA sequencing. During ALI, there was an increase in the myeloid cells, M1 macrophages, monocytes, neutrophils, and other granulocytes, whereas there was a decrease in the residential alveolar macrophages and M2 macrophages. Interestingly, LPS triggered the upregulation of CCL3, CCL4, CXCL2/3, and CXCL10 genes associated with cellular migration of various subsets of macrophages, neutrophils, and granulocytes. Furthermore, there was an increase in the frequency of myeloid cells expressing CCR1, CCR3, CCR5, and CXCR2 receptors during ALI. MicroRNA sequencing studies of vehicle versus LPS groups identified several dysregulated microRNAs targeting the upregulated chemokine genes. This study suggests that chemokine ligand–receptors interactions are responsible for myeloid cell heterogenicity and cellular recruitment to the lungs during ALI. The single-cell transcriptomics allowed for an in-depth assessment and characterization of myeloid cells involved in immune cell trafficking during ALI.
A Novel PD-L1 Antibody Promotes Antitumor Function of Peripheral Cytotoxic Lymphocytes after Radical Nephrectomy in Patients with Renal Cell Carcinoma
Authors: An Zesheng , Hsu Michelle A , Gicobi Joanina K , Xu Tianxiao , Harrington Susan M , Zhang Henan , Pavelko Kevin D , Hirdler Jacob B , Lohse Christine M , Nabavizadeh Reza , Pessoa Rodrigo R , Sharma Vidit , Thompson R Houston , Leibovich Bradley C , Dong Haidong , Lucien Fabrice 
Published: May 2023

Abstract
The intrinsic and acquired resistance to PD-1/PD-L1 immune checkpoint blockade is an important challenge for patients and clinicians because no reliable tool has been developed to predict individualized response to immunotherapy. In this study, we demonstrate the translational relevance of an ex vivo functional assay that measures the tumor cell killing ability of patient-derived CD8 T and NK cells (referred to as “cytotoxic lymphocytes,” or CLs) isolated from the peripheral blood of patients with renal cell carcinoma. Patient-derived PBMCs were isolated before and after nephrectomy from patients with renal cell carcinoma. We compared the efficacy of U.S. Food and Drug Administration (FDA)-approved PD-1/PD-L1 inhibitors (pembrolizumab, nivolumab, atezolizumab) and a newly developed PD-L1 inhibitor (H1A Ab) in eliciting cytotoxic function. CL activity was improved at 3 mo after radical nephrectomy compared with baseline, and it was associated with higher circulating levels of tumor-reactive effector CD8 T cells (CD11ahighCX3CR1+GZMB+). Treatment of PBMCs with FDA-approved PD-1/PD-L1 inhibitors enhanced tumor cell killing activity of CLs, but a differential response was observed at the individual-patient level. H1A demonstrated superior efficacy in promoting CL activity compared with FDA-approved PD-1/PD-L1 inhibitors. PBMC immunophenotyping by mass cytometry revealed enrichment of effector CD8 T and NK cells in H1A-treated PBMCs and immunosuppressive regulatory T cells in atezolizumab-treated samples. Our study lays the ground for future investigation of the therapeutic value of H1A as a next-generation immune checkpoint inhibitor and the potential of measuring CTL activity in PBMCs as a tool to predict individual response to immune checkpoint inhibitors in patients with advanced renal cell carcinoma.
Phenotypic Expressions of Chronic Leber's Hereditary Optic Neuropathy Patients with Primary and Secondary Mitochondrial Mutations Presenting at Tertiary Eye Care Center, South India
Authors: Challa Naveen Kumar , Narsini Hima Bindu , Aldakhil Sulaiman 
Published: May 2023

Aim:
The aim was to report the phenotypic expression of chronic Leber's hereditary optic neuropathy (LHON) patients with primary and secondary mitochondrial mutations presenting at a tertiary eye care center in South India.

Materials and Methods:
Of 51 patients suspected to have LHON, 15 patients turned out to be positive for mitochondrial mutations. All 15 patients with LHON are in the chronic phase of the disease and have undergone clinical examination that included visual acuity, fundus examination, visual fields, and optical coherence tomography. Clinical data were compared among the LHON patients with primary mutations of G11778A and T14484C and grouped secondary mutations. Descriptive analysis was reported.

Results:
There was no significant difference found in visual acuities in both the eyes of the three genotypic groups (G11778A, T14484C, and secondary mutations) (P > 0.05). Retinal nerve fiber layer (RNFL) analysis showed that nine patients carrying G11778A and three patients carrying secondary mutations were similar, while two patients with T14484C showed severe thinning of RNFL in all four quadrants.

Conclusions:
Among a small percentage of patients who were positive for LHON mutations, severe RNFL thinning was the most prominent finding in the T14484C mutation that differentiates from G11778A and secondary mutations. Other clinical features seem to be similar among all genotypic groups examined.
Ultrasound measurement of the distance of the phrenic nerve from the brachial plexus at the classic interscalene point and upper trunk: A volunteer-based observational study
Authors: Sripriya R , Manisha Gupta J , Arthi P R , Parthasarathy S 
Published: May 2023

ABSTRACT

Background and Aims:
The method of blocking the brachial plexus at the level of the upper trunk has been gaining popularity as a phrenic nerve–sparing alternative for interscalene block. We aimed to measure the distance of the phrenic nerve from the upper trunk and compare it with the distance between the phrenic nerve and the brachial plexus at the classic interscalene point by using ultrasound.

Method:
In this study, after ethical approval and trial registration, 100 brachial plexus of 50 volunteers were scanned from the emergence of the ventral rami and its course was traced to the supraclavicular fossa. The distance of the phrenic nerve from the brachial plexus was measured at two levels: the interscalene groove along the cricoid cartilage (classic interscalene block point) and from the upper trunk. The presence of anatomical variations of the brachial plexus, the classic traffic light sign, vessels across the plexus, and the location of the cervical oesophagus were also noted.

Results:
At the classic interscalene point, the C5 ventral ramus was observed to be just emerging or to have fully emerged from the transverse process. The phrenic nerve was identified in 86/100 (86%) of scans. The median (IQR) distance of the phrenic nerve from the C5 ventral ramus was 1.6 (1.1-3.9) mm and that of the phrenic nerve from the upper trunk was 17 (12-20.5) mm. Anatomical variations of the brachial plexus, the classic traffic light sign, and vessels across the plexus were seen in 27/100, 53/100, and 41/100 scans respectively. The oesophagus was consistently located on the left side of the trachea.

Conclusions:
There was a 10-fold increase in the distance of the phrenic nerve from the upper trunk when compared to that from the brachial plexus at the classic interscalene point.
Anaesthetic concerns in post-COVID mucormycosis at a tertiary care hospital in India: An observational study
Authors: Lahiri Swati , Kundu Asim Kumar , Ray Manjushree 
Published: May 2023

ABSTRACT
Administration of anaesthesia in post-COVID mucormycosis patients is a real challenge due to complications such as dyselectrolytemia, renal failure, multi-organ failure, and sepsis. The aim of this study was to evaluate the challenges and perioperative complications of administration of anaesthesia in terms of morbidity and mortality in patients undergoing surgical resection of post-COVID rhino-orbito-cerebral mucormycosis (ROCM). The present study was a case series, which was carried out on 30 post-COVID, biopsy-proven mucormycosis patients enrolled for ROCM resection under general anaesthesia, and all data were collected retrospectively for this series. The post-COVID mucormycosis patients had diabetes mellitus as the most common comorbidity (96.6%), and difficult airway was a common feature (60%) among them. Anaesthetic management of post-COVID mucormycosis patients is a real challenge due to associated comorbidities.
Utility of cerebral oximetry in balloon mitral valvotomy and its correlation with post-procedure neurological complications: A pragmatic prospective observational study
Authors: Wadaskar Dhawal R. , Isal Vidya G. , Jain Ruchi A. , Basantwani Shakuntala J. 
Published: May 2023

ABSTRACT

Background and Aims:
Neurological complications (NCs) are significantly associated with reduced regional cerebral saturation (rSO2) in patients undergoing cardiac surgeries, as assessed with cerebral oximetry (COx). However, limited evidence is available in patients undergoing balloon mitral valvotomy (BMV). Thus, we evaluated the utility of COx in patients undergoing BMV, the incidence of BMV-related NCs and the association of >20% reduction in rSO2 with NCs.

Methods:
This pragmatic, prospective, observational study was performed after ethical approval, over November 2018 to August 2020, in the cardiology catherization laboratory of a tertiary care hospital. The study involved 100 adult patients undergoing BMV for symptomatic mitral stenosis. The patients were evaluated at initial presentation, pre-BMV, post-BMV and 3 months after the BMV.

Results:
The incidence of NCs was 7%, including transient ischaemic attack (n = 3), slurred speech (n = 2) and hemiparesis (n = 2). A significantly greater proportion of patients with NCs had a > 20% decrease in the rSO2 (P value = 0.020). At >20% cut-off, the COx had a sensitivity and specificity of 57.1% and 80%, respectively, in the prediction of NCs. Female sex (P value = 0.039), history of cerebrovascular episodes (P value < 0.001) and number of balloon attempts (P value < 0.001) were significantly associated with NCs. Patients with and without NCs had a significantly greater post-BMV mean % change in rSO2 than pre-BMV (both right and left sides), but the magnitude of mean % change was greater in those with NCs.

Conclusions:
COx alone has low sensitivity and specificity in the prediction of NCs and cannot reliably predict the development of post-BMV NCs.
The effect of anterior esthetic fixed appliance of prematurely lost primary incisors on sound production and speech intelligibility
Authors: Melegy Reham A. A. , El-Hosary Amina M. , Serag Eldeen Shaima M. 
Published: May 2023

Aims
This work aimed to compare the sound production and speech pattern in children with prematurely extracted anterior teeth after prosthetic rehabilitation with fixed functional space maintainer.

Settings and design
The study was conducted as a clinical trial. The clinical part was carried out at Pediatric Dentistry Department, Faculty of Dentistry, Tanta University and speech evaluation and assessment was done in Phoniatric Unit, ENT Department, Faculty of Medicine, Tanta University.

Patients and methods
Twenty-five children of both sexes aged from 3 to 6 years old were included in the study. The selected children were in need for extraction of maxillary primary incisors or had already got extracted and treated by anterior esthetic fixed appliance. Children attended for speech and language evaluation at before appliance delivery, immediately after appliance insertion, 7 days after appliance insertion, 14 days after appliance insertion and 1 month after appliance insertion. And they were evaluated by articulation test, speech intelligibility test, and spectrographic parameters.

Statistical analysis used
All test statistics were performed using the SPSS software statistical package and the significance was set at P value less than or equal to 0.05.

Results
There were statistically significant differences between follow up periods for/S/,/S/, and/Z/sounds but no statistically significant difference for/z/and/∫/sounds. The mean shimmer in dB, the mean absolute Jitter and the mean noise to harmonic ratio for the sounds were diminished after adaptation of the appliance. Also, high significant differences were found between 1 month after appliance insertion and all different follow up periods. No difference with immediately after appliance insertion.

Conclusions
Replacement of prematurely lost primary incisors with fixed prosthetic appliances will assist in the proper development and intelligibility of speech. Also, in accurate consonants sounds production as/s/,/s/,/z/,/∫/(alveolar fricatives), and/z/(dental fricatives).
Evaluation of caries removal using papain versus conventional bur in primary teeth
Authors: Kandil Susan A. , Abu Hamila Nahed A. M. , Ezzat Marwa M. , Metwally Nancy M. 
Published: May 2023

Introduction
Conventional treatments for caries removal in children are often associated with pain and fear, so chemomechanical caries removal agents as Brix 3000 have been developed as one of minimally invasive technique which consists of applying a proteolytic substance that only softens the infected dentin tissue and preserves healthy tooth tissue providing more comfortable, and conservative treatment.

Objectives
The aim of this study was to evaluate the clinical efficacy of papain compared to the conventional bur preparation in caries removal in primary teeth.

Patients and methods
A randomized controlled clinical trial with sample consisted of 30 healthy children aged from 4 to 7 years old. On 60 bilaterally cavitated primary molars, a split mouth approach was used, where caries excavation was carried out with Brix 3000 on one side and traditional burs on the other. The variables evaluated were pain response, the average treatment time needed and Streptococcus mutans and Lactobacillus counts before and after caries removal.

Results
Regarding pain response, there was a statistically significant difference between the two techniques, however Brix 3000's caries removal time was significantly longer than the bur's. S. mutans and Lactobacillus counts were reduced using each of the methods, and a statistically significant difference was found; however, the reduction was slightly greater using the chemomechanical method than the conventional method, but this difference was not statistically significant.

Conclusions
Brix 3000 is an efficient alternative for caries removal in primary teeth with no pain and great microbiological efficacy, however it requires longer time.
Scanning electron microscopic study of smear layer changes following ultrasonic endoactivator irrigation system during root canal treatment of primary teeth
Authors: Ghaly Mohamed , Alsherif Aya , Khatab Arafa 
Published: May 2023

Aims
Evaluation of smear layer changes following ultrasonic endoactivator irrigation system during root canal treatment of primary teeth under Electron Microscope.

Settings and design
The study was conducted as a clinical trial. The laboratory part was carried out at Pediatric Dentistry Department, Faculty of Dentistry, Tanta University, scanning electron microscopic analysis was conducted at electron microscope unit, Faculty of Science, Alexandria University.

Patients and methods
A total of 40 intact, extracted primary canines (due to serial extraction) were collected and randomly divided into four equal groups' including 10 teeth for each. Group I: irrigation of root canal with sodium hypochlorite by a plastic syringe with end-vented needle. Group II: irrigation of root canal by a plastic syringe with side-vented needle. Group III: the same of group I in conjunction with ultrasonic endoactivator. Group IV: the same of group II in conjunction with ultrasonic endoactivator. Then preparation of specimens was done for scanning electron microscope.

Results
It was noticed that groups III and IV that used ultrasonic endoactivator had lower scores of smear layer amount than the other groups.

Conclusions
Ultrasonic endoactivator system in conjunction with conventional irrigation could improve disinfection of the root canals of primary teeth.
Marginal bone loss associated with unilateral free end mandibular implant supporting superstructures constructed with different occlusal schemes
Authors: Tamimi Sara , Mandour Mona H. 
Published: May 2023

Aims
This study was designed to evaluate the amount of bone resorption related to implant in free end saddle in response to different occlusal designs.

Patients and methods
Twenty patients with unilateral free end saddle in the lower arch till the second premolar were selected and received delayed single dental implants replacing the first molar tooth. They were divided into two main groups according to the implant superstructure deign (n = 10). Group 1: implant-supported fixed dental prosthesis which follow the principals of implant protected occlusion, and with the occlusal contact area of the crown smaller than the occlusal contact area of adjacent tooth. Group 2: implant-supported fixed dental prosthesis which follow the principals of implant protected occlusion, and with the occlusal contact area of the crown larger than the occlusal contact area of adjacent tooth. Patients were evaluated for the amount of marginal bone level at the time of crown insertion, after 3 and 6 months of function.

Results
There was a statistically significant change by time in marginal bone loss in both groups especially during the first 3 months. However, there was no statistically significant difference between marginal bone loss regarding the two groups.

Conclusion
It was concluded that increasing the occlusal contact area of the implant superstructure has no effect on marginal bone loss.