bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetic ketoacidosis diagnosis in a hospital setting
Authors: Healy Amber M. , Faherty Mallory , Khan Zeryab , Emara Naveen , Carter Cody , Scheidemantel Andrew , Abu-Jubara Musa , Young Robert 
Published: July 2023

Abstract

Context
Diabetic ketoacidosis (DKA) is an endocrine emergency that can occur in people with diabetes. Its incidence is estimated to be 220,340 hospital admissions each year. Treatment algorithms include fluid resuscitation, intravenous (IV) insulin infusion, and scheduled electrolyte and glucose monitoring. The misdiagnosis of DKA in the setting of hyperglycemic emergencies results in overtreatment and unnecessary increases in healthcare utilization and costs.

Objectives
The aims of this study were to determine how often DKA is overdiagnosed in the context of other acute hyperglycemic emergencies, to describe the baseline characteristics of patients, to determine the hospital treatments for DKA, and to identify the frequency of endocrinology or diabetology consultation in the hospital setting.

Methods
A retrospective chart review was conducted utilizing charts from three different hospitals within a hospital system. Charts were identified utilizing ICD-10 codes for admissions to the hospital for DKA. If the patient was over 18 and had one of the diagnostic codes of interest, the chart was reviewed for further details regarding the criteria for DKA diagnosis as well as admission and treatment details.

Results
A total of 520 hospital admissions were included for review. DKA was incorrectly diagnosed in 28.4 % of the hospital admissions reviewed, based on a review of the labs and DKA diagnostic criteria. Most patients were admitted to the intensive care unit (ICU) and treated with IV insulin infusion (n=288). Consultation of endocrinology or diabetology occurred in 40.2 % (n=209) of all hospital admissions, and 128 of those consults occurred in ICU admissions. The diagnosis of DKA was incorrect in 92 of the patients admitted to the medical surgical unit (MSU) and in 49 of patients admitted to the ICU.

Conclusions
Almost one third of hospital admissions for hyperglycemic emergencies were misdiagnosed and managed as DKA. DKA diagnostic criteria are specific; however, other diagnoses like hyperosmolar hyperglycemic syndrome (HHS), hyperglycemia, and euglycemic DKA can make an accurate diagnosis more complicated. Education directed at improving the diagnostic accuracy of DKA among healthcare providers is needed to improve diagnostic accuracy, ensure the appropriate use of hospital resources, and potentially reduce costs to the healthcare system.
Variant in the allosteric domain of CPS1 protein associated with effectiveness of N-carbamoyl glutamate therapy in neonatal onset CPS1 deficiency
Authors: Gragnaniello Vincenza , Gueraldi Daniela , Puma Andrea , Commone Anna , Loro Christian , Cazzorla Chiara , Häberle Johannes , Burlina Alberto B. 
Published: July 2023

Abstract

Objectives
Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a severe urea cycle disorder. Patients can present with hyperammonemic coma in the first days of life. Treatment includes nitrogen scavengers, reduced protein intake and supplementation with L-arginine and/or L-citrulline. N-carbamoyl glutamate (NCG) has been hypothesized to stimulate the residual CPS1 function, although only few patients are reported.

Case presentation
We report a patient with neonatal-onset CPS1 deficiency who received NCG in association with nitrogen scavenger and L-citrulline. The patient carried the novel variants CPS1-c.2447A>G p.(Gln816Arg) and CPS1-c.4489T>C p.(Tyr1497His). The latter is localized in the C-terminal allosteric domain of the protein, and is implicated in the binding of the natural activator N-acetyl-L-glutamate. NCG therapy was effective in controlling ammonia levels, allowing to increase the protein intake.

Conclusions
Our data show that the response to NCG can be indicated based on the protein structure. We hypothesize that variants in the C-terminal domain may be responsive to NCG therapy.
Creep analysis of the flax fiber-reinforced polymer composites based on the time–temperature superposition principle
Authors: Xu Bowen , van den Hurk Bart , Lugger Sean J. D. , Blok Rijk , Teuffel Patrick 
Published: July 2023

Abstract
Natural plant fiber-reinforced polymer composites (PFRP) have emerged as an environmental-friendly material in the construction industry, but their creep behavior is a critical concern for load-bearing structures. This study investigates the creep behavior of flax fiber-reinforced polymer composites (FFRP) using the time–temperature superposition principle (TTSP). Due to the application of TTSP on the tensile creep behavior of FFRP is not fully understood, three potential methods for calculating the critical parameters during TTSP are compared to obtain an efficient application method to build the creep master curve. A 2,000-h long-term creep test is conducted parallelly on the same sample to validate the accuracy of the creep analysis results. The study proposes an ideal method to determine the key parameters in TTSP, providing valuable insights for the practical application of PFRP in the construction industry. Meanwhile, the research results in this study would be helpful in better understanding the creep behavior of FFRP via short-term accelerated tests.
Use of artificial neural networks to identify and analyze polymerized actin‐based cytoskeletal structures in 3D confocal images
Authors: Park Doyoung 
Published: July 2023

We propose an artificial neural network (ANN) as a kernel function of the recognizer of legitimate CABs from candidate CABs, that does not need human interventions. The performance of the recognizer shows noticeable recognition accuracy and addresses shortcomings of previous methods, including the need for human visual validation to recognize CABs from candidate CABs. Further, it helps to find and reduce errors resulting from human visual validation, which in turn would provide biologists/biophysicists a more comprehensive. understanding of a CAB.BackgroundLiving cells need to undergo subtle shape adaptations in response to the topography of their substrates. These shape changes are mainly determined by reorganization of their internal cytoskeleton, with a major contribution from filamentous (F) actin. Bundles of F‐actin play a major role in determining cell shape and their interaction with substrates, either as “stress fibers,” or as our newly discovered “Concave Actin Bundles” (CABs), which mainly occur while endothelial cells wrap micro‐fibers in culture.MethodsTo better understand the morphology and functions of these CABs, it is necessary to recognize and analyze as many of them as possible in complex cellular ensembles, which is a demanding and time‐consuming task. In this study, we present a novel algorithm to automatically recognize CABs without further human intervention. We developed and employed a multilayer perceptron artificial neural network (“the recognizer”), which was trained to identify CABs.ResultsThe recognizer demonstrated high overall recognition rate and reliability in both randomized training, and in subsequent testing experiments.ConclusionIt would be an effective replacement for validation by visual detection which is both tedious and inherently prone to errors.
Viaje de Turquía y el uso de los personajes populares como refuerzo de la veracidad del relato
Authors: Mosquera Juan José 
Published: July 2023

Viaje de Turquía es un texto en el que se combinan los rasgos del diálogo, la novela, el tratado y la autobiografía. El autor da mucha importancia a la veracidad, a comunicar al lector la impresión de que el contenido de la obra es completamente cierto. Entre las diversas técnicas utilizadas para lograr este propósito está la de la construcción de los personajes a partir del folklore popular. De esta forma el lector ya asume una serie de características ligadas a estos personajes por el conocimiento popular y se construye sobre ellas unos personajes literarios complejos.Palabras clave: Juan de Voto a Dios, Mátalas Callando, Pedro de Urdemalas, Viaje de Turquía.
Las amazonas, California, Rodríguez de Montalvo y las crónicas americanas
Authors: Luis Jiménez Isidro 
Published: July 2023

El artículo traza la evolución medieval del mito de las amazonas desde su origen hasta su plasmación en Las Sergas de Esplandián, prestando especial atención a la dimensión americana del mismo, presente tanto en la influencia de las noticias del primer viaje colombino en el texto de Montalvo como en la evolución paralela del mito de California.Palabras clave: Amazonas, Amadís de Gaula, Rodríguez de Montalvo
Rutas razonables en torno a una pregunta indescifrable: ¿qué es la poesía?
Authors: Medina Poveda Diego 
Published: July 2023

En palabras de F. Schlegel «no se puede hablar de poesía sino poéticamente». El siguiente ensayo intentará mediante un acercamiento parabólico establecer algunas pinceladas conceptuales que nos permitan resolver suscintamente el enigma del sentido de la creación poética. Para ello, desde un prisma ensayístico, se hace un recorrido por épocas y tratados literarios, en los que encontramos a autores como Aristóteles, Horacio, Wordsworth, Coleridge, Shelley, F. Schlegel, Heidegger, Rilke, Juan Ramón Jiménez, Octavio Paz, Gil de Biedma, Baudelaire, Mallarmé y Valéry.Palabras clave: Poética, poesía, ensayo literario
El sentido de lo sagrado y el 11-S: Antonio Muñoz Molina en Ventanas de Manhattan
Authors: Mosquera Ramallo Juan José 
Published: July 2023

La creación de ficción tras los atentados del 11 de septiembre de 2001 se ha visto afectada por un fenómeno de sacralización alrededor del incidente que la restringe o condiciona. Antonio Muñoz Molina ha abordado el tema del 11-S en su libro Ventanas de Manhattan. El autor español, consciente o inconscientemente, reconoce lo sagrado de lo allí acaecido y utiliza tácticas narrativas que le permiten abordar el 11-S sin profanar o desacralizar este evento, creando así un discurso que intenta arrojar luz y aportar significado a lo ocurrido aquel fatídico día.Palabras clave: 11-S, sagrado, inexpresable, narración, imaginación.The sense of the sacred and 9/11: Antonio Muñoz Molina in Ventanas de ManhattanAbstract: The creation of fiction in the aftermath of the 9/11 attacks has been affected by a phenomenon of sacralisation around this event which shapes or restricts it. Antonio Muñoz Molina has addressed the topic of 9/11 in his book Ventanas de Manhattan. The Spanish author, consciously or unconsciously, acknowledges the sacredness of what happened there and uses narrative tools which allow him to deal with 9/11 without profaning or desecrating it, creating in this way a discourse which sheds light on and provides meaning to the occurrences of that dreadful day.Key words: 9/11, sacred, unspeakable, narrative, imagination.
Un acercamiento a la narración fotográfica de Juan Rulfo
Authors: Gacińska Weselina 
Published: July 2023

El artículo trata de describir las diferentes facetas de la obra fotográfica de Juan Rulfo: su aspecto técnico, su lugar en el contexto de la fotografía mexicana y su aportación antropológica. El análisis se concentrará ante todo en la fotografía antropológica y arquitectónica para mostrar la visión de decadencia que predomina en la producción artística de Rulfo. Se tratará también el tema de la narración fotográfica, las fotografías sin foco como un punto de connotación entre el arte visual y la literatura, así como la presencia y el simbolismo de la fotografía como soporte físico y artefacto.Palabras clave: fotografía mexicana, antropología, Juan Rulfo, estudios interdisciplinares.An approach to the photographic narration of Juan RulfoAbstract: The purpose of the article is to describe the different facets of Juan Rulfo’s photography – their technical aspects, its place in the context of Mexican photography and the anthropological contribution. The analysis will focus primarily on anthropological and architectural photography to show the vision of decadence prevalent in Rulfo’s artistic production. The paper discusses also the photographic narration and unfocused photography as a point of connotation between visual art and literature, as well as the presence and symbolism of photography as a cultural artifact.Key words: Mexican photography, anthropology, Juan Rulfo, interdisciplinary studies
Features of the Transformation of the Decade of the Lithuanian Media
Authors: Ustilaitė Darija 
Published: July 2023

World events, the development of information technology and other factors have increased the flow of information and changed the nature of journalists’ work over the last 10 years. However, journalists, despite the transformation and increased opportunities to expand the range of news, can still cover only a certain part of the information. Media workers, due to limited space, time or human resources, select just part of the events that become news. Selected news published in the media influence how society perceives and interprets reality.
In this article content analysis and in-depth interviews were used to investigate the transformations that Lithuanian media has undergone over the last 10 years, also the aim was to identify which news media has paid and are paying the most attention to, how and why the specificity of news has changed.
Dose and Time-Dependent Lipopolysaccharide Exposure on A549 Cell Model Influences Pro-Inflammatory Cytokine Interleukin 8
Authors: Sumayyah Sarah , Suryadarma Prayoga , Noverina Rachmawati , Ayuningtyas Wireni , Wirakusumah Firman Fuad , Faried Ahmad 
Published: July 2023

Hyperinflammation in COVID-19 patients is one of the causes of the high mortality rate of COVID-19. An in vitro model mimicking the inflammatory responses in COVID-19 patients is important in the efforts of finding new drug candidates for this disease. Lipopolysaccharide (LPS) can increase the proinflammatory cytokine interleukin 8 in response to the presence of foreign substances. This preliminary study sought to explore the use of the A549 cells as an in vitro inflammatory model. This study was conducted from August to November 2022 at the stem cell research and development laboratory of Bio Farma Indonesia. The exposure of 100, 500, and 1000 g/mL doses of LPS administered for 24, 72, and 120 hours on the A549 cells was analyzed for cell viability, population doubling time (PDT), and the presence of proinflammatory cytokine IL-8. The group differences were examined using one- and two-way analysis of variance in IBM SPSS Statistics Version 29, with a p-value of 0.05 considered significant. Cells exposed to a dose of 1000 g/mL LPS had a lower viability and a higher proliferation rate (p<0.05) based on the viability and PDT. Viability, PDT, and pro-inflammatory cytokines showed concentration- and time-dependent responses. Therefore, increased levels of the proinflammatory cytokine IL-8 in cells exposed to LPS at a dose of 1000 g/mL for 24 hours can be used as a mimic to study hyperinflammation in COVID-19 patients.
Pediatric Respiratory Illnesses: An Update on Achievable Benchmarks of Care
Authors: Reyes Mario A. , Etinger Veronica , Hronek Carla , Hall Matt , Davidson Amber , Mangione-Smith Rita , Kaiser Sunitha V. , Parikh Kavita 
Published: July 2023

BACKGROUND AND OBJECTIVES
Pediatric respiratory illnesses (PRI): asthma, bronchiolitis, pneumonia, croup, and influenza are leading causes of pediatric hospitalizations, and emergency department (ED) visits in the United States. There is a lack of standardized measures to assess the quality of hospital care delivered for these conditions. We aimed to develop a measure set for automated data extraction from administrative data sets and evaluate its performance including updated achievable benchmarks of care (ABC).

METHODS
A multidisciplinary subject-matter experts team selected quality measures from multiple sources. The measure set was applied to the Public Health Information System database (Children’s Hospital Association, Lenexa, KS) to cohorts of ED visits and hospitalizations from 2017 to 2019. ABC for pertinent measures and performance gaps of mean values from the ABC were estimated. ABC were compared with previous reports.

RESULTS
The measure set: PRI report includes a total of 94 quality measures. The study cohort included 984 337 episodes of care, and 82.3% were discharged from the ED. Measures with low performance included bronchodilators (19.7%) and chest x-rays (14.4%) for bronchiolitis in the ED. These indicators were (34.6%) and (29.5%) in the hospitalized cohort. In pneumonia, there was a 57.3% use of narrow spectrum antibiotics. In general, compared with previous reports, there was improvement toward optimal performance for the ABCs.

CONCLUSIONS
The PRI report provides performance data including ABC and identifies performance gaps in the quality of care for common respiratory illnesses. Future directions include examining health inequities, and understanding and addressing the effects of the coronavirus disease 2019 pandemic on care quality.
The development of composite reinforced hybrid fiber musa acuminata stem-hibiscus tiliaceust bark with filler liquid rubber as vehicle bumper
Authors: Darmo Sujita , Sutanto Rudy 
Published: July 2023

The characterized of the polyester composites reinforced of the hybrid fiber musa acuminata stem fiber (MASF)-hibiscus tiliaceust bark fiber (HTBF) with liquid rubber filler was studied. The object of research is the polyester composite material, hybrid natural fiber reinforcement and filler Carboxyl Terminated Butadiene Acrylonitryle (CTBN). The polyester composite material which is used as a vehicle bumper, is easily broken and has low heat resistance so that its shape easily changes/shrinks due to heat. This research aims to develop the tensile strength, impact toughness and heat resistance of polyester composites. The reason for using the MASF-HTBF hybrid fiber as a reinforcement for polyester composite materials is because MASF and HTBF are natural fibers that have great potential to be developed to improve the mechanical properties of polyester composites, as substitutes for synthetic fibers. In this study, the conditions of MASF and HTBF were given alkaline treatment by immersing them in 5 % NaOH solution for 24 hours then drying. The combined/hybrid ratio between the MASF and CTBF volume fractions is: 5 %:25 %, 10 %:20 % and 15 %:15 %. To increase impact toughness, CTBN filler is added with variations of 5 %, 10 %. The mechanical characteristics of the specimens were carried out by means of a tensile test and an impact test. The change in mass or shrinkage as a result is tested by TGA. The results showed that the MASF-HTBF hybrid fiber-reinforced polyester composite material with CTBN filler has better mechanical properties than single natural fibers, so it is important to develop it further as a material for making vehicle bumper
Improving the technology of the synthesis of fatty acid monoglycerides using the glycerolysis reaction
Authors: Saveliev Dmytro , Petrova Olena , Yashchenko Oleksandr , Rudakov Serhii , Harbuz Serhii , Shevchuk Natalia , Kachanova Tetiana , Gill Michael , Bolhova Nataliia , Borozenets Nataliia 
Published: July 2023

The object of research is the process of fat glycerolysis in order to obtain fatty acid monoglycerides.
Monoglycerides are an important component of chemical, pharmaceutical, cosmetic, and food industry products. These substances are used as emulsifiers, structure formers, complex formers, etc. The industrial production of monoglycerides involves the use of complex technologies, as well as dangerous and unstable catalysts. An urgent task is to develop new catalysts and improve technologies for monoglycerides obtaining.
The technology for the synthesis of monoglycerides by the glycerolysis method, which involves the reaction of vegetable hydrogenated fat with glycerol, was studied. Potassium glyceroxide was used as a catalyst, which is effective and safe in terms of production and use.
Hydrogenated unrefined fat according to DSTU 5040 (CAS Number 68334-28-1) was used. The fat has non-standard parameters: the melting point is 51 °C, the mass fraction of moisture and volatile substances is 0.3 %, the acid value is 3.2 mg KOH/g, the peroxide value is 7.6 ½ O mmol/kg.
The process duration was 90 minutes, the glycerol concentration was 50 %. Rational conditions for glycerolysis were determined: catalyst concentration (1.5 %) and temperature (140 °C). Under these conditions, the product ensured the stability of the “water – sunflower oil” emulsion of 96.8 %, the concentration of monoglycerides in the system was 0.1 %. Product parameters: mass fraction of monoglycerides – 72.5 %, free glycerol – 1.5 %, acid value – 1.7 mg KOH/g.
The research results make it possible to improve the glycerolysis process using a new catalyst and obtain monoglycerides with high emulsifying ability. This will increase the profitability of the enterprise and increase the volume of production of high-quality monoglycerides for various industries
Determining the patterns of extinguishing polar flammable liquids with a film-forming foaming agent
Authors: Tsapko Yuriy , Likhnyovskyi Ruslan , Tsapko Аleksii , Kovalenko Vitalii , Slutska Oksana , Illiuchenko Pavlo , Sokolenko Kostiantyn , Gulyk Yuriy 
Published: July 2023

An issue related to the use of foaming agents to extinguish fires involving flammable liquids is to ensure the efficiency of vapor insulation of flammable liquid and the foam stability during operation. Therefore, the object of research was a change in the insulating properties of the foaming agent film when interacting with a polar combustible substance. It has been proven that the presence of foaming agent on a flammable liquid leads to the formation of an insulating film on the surface resistant to the combustion temperature of the liquid, due to which re-ignition shifts towards longer time. A film of foaming agent was formed on the surface of the flammable liquid by leaking from the screen, which led to the insulation of the surface. The measured contact area of the foaming film with the electrode was more than 6.2·10-3 m2, which indicates the formation of a barrier for temperature, which collapses over time. According to experimental data on changes in electrical resistance, the critical contact area of the foaming film with the electrode was calculated, at which the film is destroyed. Based on the derived dependences, the change in the process of mass transfer of the foaming film to a flammable liquid was calculated, equal to about 800 s. The maximum possible mass transfer of the foaming agent into the flammable liquid and the reduction of insulation capacity were evaluated. The peculiarities of foam supply to the surface of alcohol through the screen are that the quenching time was about 156 s while the critical intensity of the supply of the working solution of the foaming agent was 0.054 dm3/(m2·s). And the time interval before re-ignition was about 470 s, which is enough to cool the fire site. Thus, there is reason to assert the possibility of targeted control over the processes of extinguishing polar flammable liquids with a foaming agent