bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparable Outcomes Using Oral Dydrogesterone versus Intramuscular Progesterone in Frozen Embryo Transfer: a Retrospective Cohort Study
Authors: Bachar Gal , Haskia Chen , Fainaru Ofer 
Published: January 2023

Abstract
Background
Optimal intensive luteal support in frozen embryo transfer (FET) cycles in which a corpus luteum is not present has not been determined and several treatment regimens are currently practiced. Previous reports suggest that vaginal progesterone alone is probably insufficient. The use of intramuscular progesterone is considered efficacious but much less tolerable. The objective of this study was to compare a more tolerable regimen using micronized vaginal progesterone (MVP) and oral dydrogesterone versus MVP and intramuscular progesterone (IM) for luteal support.
Methods
A retrospective study of patients undergoing single blastocyst FET in a tertiary center IVF unit. All patients (n = 100) received oral estradiol in the follicular phase and supplemented with MVP for luteal phase support. One group (n = 50) received additional dydrogesterone (10 mg TID) and the other (n = 50) intramuscular progesterone (100 mg every 3 days).
Results
The two groups were similar with regard to age; BMI; infertility etiology and duration; and basal hormonal levels. Biochemical pregnancy rates (34% vs 42%, p = 0.54) and clinical pregnancy rates (26% vs. 36%, p = 0.39) were lower in the MVP + oral dydrogesterone group as compared to the MVP + IM progesterone group. Nevertheless, this difference was not statistically significant. Abortion rates were similar (2%) and there were no ectopic pregnancies in both groups.
Conclusion
This retrospective cohort study demonstrates noninferiority of MVP and oral dydrogesterone as compared to MVP and intramuscular progesterone for luteal support in FET cycles. The better profile of adverse effects and tolerability makes it a suitable protocol for FET.
Prevalence of polycystic ovary syndrome and its clinical and hormonal profile in young females with type 1 diabetes mellitus: experience from a teaching Institution of India
Authors: Dominic Nibu , Sharma Lokesh , Dabadghao Preeti , Mohindra Namita 
Published: January 2023

Abstract
Objective
To investigate the prevalence of polycystic ovary syndrome and its clinical and hormonal profile in females with type 1 diabetes.
Materials and methods
65 T1DM females were evaluated for presence of PCOS and compared with age and BMI matched females with PCOS without diabetes.
Results
According to Rotterdam criteria 18/65 (27%) had PCOS. Prevalence of androgen excess, hirsutism, menstrual dysfunction and PCOM was 26%, 3%, 21% and 52% respectively. The females with T1DM who had PCOS did not differ from group without PCOS. Among those who had PCOS, the mean daily insulin dose (U/kg/day) was higher in girls who had post-pubertal onset of diabetes (median, IQR; 1.2, 0.95-1.56) vs pre-pubertal (0.81, 0.75-1.2) (p=0.055) which was close to statistical significance.
When the group of T1DM with PCOS was compared with PCOS females without diabetes, they had significantly lower hirsutism score (median, IQR; 1.5, 0-3 vs. 11.5, 0 – 16.5, p= 0.04), significantly higher waist hip ratio (0.91, 0.89-0.99 vs. 0.86, 0.80 – 0.89, p= 0.004) and SHBG (in nmol, 54.4, 38-86.2 vs. 28.3, 20.4-37.4, p= 0.004)
Conclusion
Females with T1DM have a high prevalence of menstrual abnormalities, hyperandrogenism and PCOS which is not related to metabolic control, age of onset of diabetes or insulin dose.
Influence of benign prostatic hyperplasia patterns detected with MRI on the clinical outcome after prostatic artery embolization
Authors: Boschheidgen Matthias , Al-Monajjed Rouvier , Minko Peter , Jannusch Kai , Ullrich Tim , Radke Karl-Ludger , Michalski Rene , Radtke Jan Phillip , Albers Peter , Antoch Gerald , Schimmöller Lars 
Published: January 2023

Abstract
Background
To investigate the influence of MRI hyperplasia patterns in benign prostate hyperplasia (BPH) and tissue composition on outcome parameters in a collective of patients undergoing prostate artery embolization (PAE).
Materials & Methods
This retrospective study included patients (median age 72y) with the diagnosis of BPH, who underwent magnetic resonance imaging (MRI) of the prostate followed by PAE at a single centre. MRI scans were evaluated and BPH patterns were determined according to Wasserman type and a modified BPH classification. Additionally, scans were evaluated regarding the presence of adenomatous-dominant benign prostatic hyperplasia (AdBPH). Lower urinary tract symptoms (LUTS) were assessed using the International Prostate Symptom Score (IPSS) and urinary flow rate (Qmax). Follow-up examination included MRI and clinical outcome.
Results
For clinical outcome at follow-up, IPSS showed median reduction of 54% (IQR 41 - 75%) and Qmax improved by 4.1 ml/s. We noted significant reduction in volume, intraprostatic protrusion and prostatic urethra angle in our collective (p<0.01). Median volume reduction was 25% (IQR 15% - 34%). Multiple linear regression model showed significant effect of high initial volume on reduction in IPSS scores after treatment (p<0.01). Presence of AdBPH was significantly associated with both volume loss and clinical improvement in terms of IPSS reduction (p<0.01). Neither BPH patterns based on the Wassermann type nor modified BPH classifications were significantly related with postinterventional IPSS and volume loss.
Conclusions
Men benefit from PAE regardless the macroscopic BPH MRI pattern. Preinterventional prostate volume, presence of AdBPH on MRI, and IPSS should be considered for outcome prognosis after prostatic artery embolization.
Genetic analysis and QTL mapping for silique density in rapeseed (Brassica napus L.)
Authors: Ma Xingrong , Wang Jinhua , Gu Yongfen , Fang Pengpeng , Nie Wenjing , Luo Ruirui , Liu Jin , Qian Wei , Mei Jiaqin 
Published: January 2023

Abstract
Silique density is one of the critical factors to determine seed yield and plant architecture in rapeseed (Brassica napus L.), however, the genetic control of this trait is largely unknown. In this study, the genetic model for silique density on main inflorescence (SDMI) of rapeseed was estimated according to the phenotypic data of P1 (an inbreed line with high SDMI), P2 (an inbreed line with low SDMI), F1, F2, BC1P1 and BC1P2 populations, revealing that SDMI is probably controlled by multi minor genes with or without major gene. The QTLs for SDMI and its component characters including silique number on main inflorescence (SNMI) and main inflorescence length (MIL) were consequently mapped from a DH population derived from P1 and P2 by using a genetic linkage map constructed by RAD-seq technology. A total of eight, 14 and three QTLs were identified for SDMI, SNMI and MIL under three environments, respectively, with an overlap among SDMI and SNMI in 55.7-75.4 cM on linkage group C06 which corresponding to 11.6-27.3 Mb on chromosome C06. Genomic resequencing was further conducted between a high- and a low-SDMI pool constructed from the DH population, and QTL-seq analysis identified a 0.15-Mb interval (25.98-26.13 Mb) from the C06-QTL region aforementioned. Transcriptome sequencing and qRT-PCR identified one possible candidate gene (BnARGOS) from the 0.15-Mb interval. This study will provide novel insights into the genetic basis of SD in rapeseed.
Tailoring the resonant modes in liquid crystal based all-dielectric metasurfaces
Authors: Sakhare Pratiksha A , Atmakuri Madhunika , DONTABHAKTUNI JAYASRI 
Published: January 2023

Abstract
High refractive index dielectic metasurfaces are being increasingly studied for their novel light-matter interactions such as Huygen's lens, absolute transmission and complete absorption. Liquid crystal is a versatile medium with high dielectric anisotropy and hence interaction of light with the dielectric metasurfaces immersed in liquid crystal medium show complex behaviour compared to isotropic media. Most of the investigations on liquid crystal based electromagnetic response of dielectric metasurfaces focus on tunability of resonant frequencies and switching between the resonant states as a function of external stimuli such as electric field, temperature, etc. In the current work we present a detailed investigation of scattering response, near-field and far-field radiation profiles of cubic Tellurium metasurfaces as a function of liquid crystal orientations in infrared frequencies.We show that the near-field and far-field radiation profiles of primary resonant modes - electric dipoles and magnetic dipoles reorient as a function of liquid crystal orientations. In particular, we study the effect of liquid crystal orientations on novel non-radiative states called anapoles. It is observed that liquid crystal orientations effect the excitation and orientation of anapole states within the Tellurium structures. This paves way for design of an electrically-driven switch between non-radiative and radiative states. Further, controlling the near-field and far-field radiation profiles opens up possibilities in designing liquid crystal based tunable multi-functional metasurfaces which can change the directionality of incident light.
Activator-blocker model of transcriptional regulation by pioneer-like factors
Authors: Onichtchouk Daria , Riesle Aileen , Gao Meijiang , Rosenblatt Marcus , Hermes Jacques , Hass Helge , Gebhard Anna , Veil Marina , Gruening Bjoern , Timmer Jens 
Published: January 2023

Abstract
Zygotic genome activation (ZGA) in the development of flies, fish, frogs and mammals depends on pioneer-like transcription factors (TFs). Those TFs create open chromatin regions, promote histone acetylation on enhancers, and activate transcription. Here, we use the panel of single, double and triple mutants for zebrafish genome activators Pou5f3, Sox19b and Nanog, multi-omics and mathematical modeling to investigate the combinatorial mechanisms of genome activation. We show that Pou5f3 and Nanog act differently on synergistic and antagonistic enhancer types. Pou5f3 and Nanog both bind as pioneers on synergistic enhancers, promote histone acetylation and activate transcription. Antagonistic enhancers are activated by pioneer binding of one of these factors. The other TF binds as non-pioneer, competes with the activator and blocks all its effects, partially or completely. This activator-blocker mechanism mutually restricts widespread transcriptional activation by Pou5f3 and Nanog and prevents premature expression of late developmental regulators in the early embryo
Incommensurate charge-stripe correlations in the kagome superconductor CsV3Sb5-xSnx
Authors: Wilson Stephen , Kautzsch Linus , Oey Yuzki , Li Hong , Ren Zheng , Ortiz Brenden , Pokharel Ganesh , Seshadri Ram , Ruff Jacob , Kongruengkit} Terawit , Harter John , Wang Ziqiang , Zeljkovic Ilija 
Published: January 2023

Abstract
The new class of AV3Sb5 (A=K, Rb, Cs) kagome metals host unconventional charge density wave states seemingly intertwined with their low temperature superconducting phases. The nature of the coupling between these two states and the potential presence of nearby, competing charge instabilities however remain open questions. This phenomenology is strikingly highlighted by the formation of two ''domes” in the superconducting transition temperature upon hole-doping CsV3Sb5. Here we track the evolution of charge correlations upon the suppression of long-range charge density wave order in the first dome and into the second of the hole-doped kagome superconductor CsV3Sb5-xSnx. Initially, hole-doping drives interlayer charge correlations to become short-ranged with their periodicity diminished along the interlayer direction. Beyond the peak of the first superconducting dome, the parent charge density wave state vanishes and incommensurate, quasi-1D charge correlations are stabilized in its place. These competing, unidirectional charge correlations demonstrate an inherent electronic rotational symmetry breaking in CsV3Sb5, and reveal a complex landscape of charge correlations within its electronic phase diagram. Our data suggest an inherent 2kf charge instability and competing charge orders in the AV3Sb5 class of kagome superconductors.
Assessment of factors influencing physicians’ intention to prescribe transfusion using the theory of planned behavior
Authors: Liao Yu-Han , Tang Kung-Pei , Chou Chih-Yu , Kuo Chien-Feng , Tsai Shin-Yi 
Published: January 2023

Abstract
Background:
Blood shortage is a persistent problem affecting Taiwan’s health-care system. The theory of planned behavior (TPB) has been commonly used in studies of health advocacy. The purpose of this study was to develop a questionnaire measuring clinicians’ intention to prescribe transfusion based on the TPB.
Method:
A questionnaire comprising 15 items for assessing clinicians’ intention to prescribe blood transfusion was developed, and it collected demographic characteristics tested patient blood management (PBM) and perceived knowledge of PBM. Furthermore, it contained four subscales related to the TPB. A total of 129 clinicians participated in this pilot study between July and December, 2020. Item analysis and exploratory factor analysis were conducted to examine the validity and reliability of this measurement instrument.
Results:
The results indicated no statistically significant correlations between the demographic characteristics and test scores. Regarding perceived knowledge, the results of a one-way analysis of variance revealed that the effect of age, hierarchy of doctors, and education level was significant. In terms of subjective norms, a significant effect for education level was noted [t (129) = 2.28, p < 0.05], with graduate school graduates receiving higher scores than college graduates. An analysis of variance demonstrated the effect of hierarchy, education level, and medical specialty on perceived behavioral control. The results of the regression analyses revealed that perceived knowledge (β = 0.32, p < 0.01) and subjective norms (β = 0.22, p < 0.05) were significantly related to clinicians’ behavioral intention.
Conclusions:
This study revealed that factors affecting clinicians’ blood transfusion management can be explained using the TPB-based questionnaire. This study demonstrated that physicians’ perception of whether most people approve of PBM and their self-assessment of their PBM knowledge affect their intention to proceed with PBM. According to this finding, a support system among physicians must be established and maintained to increase physician’s confidence in promoting PBM.
Genetic analysis of stripe rust resistance in CIMMYT common wheat line KFA/2*KACHU under Chinese rust environment
Authors: Lan Caixia , Yin Yuruo , Yuan Chan , Zhang Yichen , Li Shunda , Bai Bin , Wu Ling , Ravi Sing 
Published: January 2023

Abstract

Breeding resistant wheat variety is the most economic and efficient way to manage wheat stripe rust, while identification of new stripe rust resistance gene and development the molecular markers will be very useful for wheat breeder in the breeding program. In the present study, a recombinant inbred line (RIL) population derived from a cross of the resistant parent KFA/2*KACHU and susceptible parent Apav#1 was used to map stripe rust resistance loci. In combination of GBS genotyping platform and BSR-Seq method, we mapped a new race-specific stripe rust resistance gene on wheat chromosome 5BL at the seedling stage, temporarily named as YrK. TraesCS5B02G330700 encoded a receptor-like kinase was considered as the key candidate gene of YrK based on virus induced gene silencing (VIGS) method. Its expression showed a significant up-regulated at 24h after inoculation and the functional molecular markers were developed based on the polymorphic SNPs in the CDS region. In addition, a total of four adult plant resistance (APR) loci were identified on wheat chromosome 1BL, 2AS, 2BS and 4AL, respectively. Among these, QYr.hazu-1BL and QYr.hazu-2AS was verified as the known resistance genes Lr46/Yr29/Pm39 and Yr17, respectively. QYr.hazu-2BS was a new APR locus and the closely linked SNP markers were converted into breeder-friendly KASP markers.
A Multi-Material Additive Manufacturing virtual prototyping method for design to improve part strength
Authors: Kakaraparthi Shivaram , Chen Niechen 
Published: January 2023

Abstract
Multi-Material Additive Manufacturing (MMAM) offers new opportunities to realize components with more integrated features and functionalities in reduced manufacturing costs by eliminating assembly processes. However, the weak mechanical bond between different materials often results in unexpected weakness sections that reside around the multi-material boundary interface. Thus, strengthening the boundary interface is critical to enabling the wide application of MMAM processes in production. Our work approaches this challenge by introducing a new virtual prototyping method to strengthen MMAM parts by facilitating the design and planning process. In our work, a computational part strength prediction model is built, and this model is used to quickly and realistically predict the mechanical strength of a part design within the context of its manufacturing plan. This enables fast iteration of redesigns to create parts that can be directly printed with improved strength. Compared to the commonly used Design of Experiment-based approaches, this new virtual prototyping method offers a more time and cost-efficient solution that delivers better designs in a shorter design cycle and with no material wastage by eliminating the need for physical test printing.
Therapeutic potential of hesperidin: Apoptosis induction in breast cancer cell lines
Authors: ONDER Gozde Ozge , GOKTEPE Ozge , BARAN Munevver , BITGEN Nazmiye , AYDIN Funda , Yay Arzu 
Published: January 2023

Abstract

Purpose
Hesperidin is a flavonoid commonly found in citrus fruits. Studies have shown that hesperidin has anti-inflammatory, analgesic, and antimicrobial properties, as well as its effectiveness in carcinogenesis. In this paper, we aim to investigate the molecular mechanisms of hesperidin-induced apoptosis in MCF-7 and MDA-MB-231 cancer cells.
Methods
Hesperidin’s 50% inhibitory concentrations in the cells were evaluated by the MTT assay. Cell cycle analysis of hesperidin-treated cells was then performed, as well as immunocytochemical analysis of the effect on the apoptosis pathway (TUNEL, Bax, and Bcl-2 expression).
Results
Moreover, hesperidin induced cell apoptosis in MCF-7 breast cancer cells by inhibiting Bcl-2 and enhancing Bax expression at protein levels. On the other hand, hesperidin caused apoptosis in the MDA-MB-231 breast cancer cell line, but it did not activate the Bax/Bcl-2 pathway. Hesperidin also induced cell cycle arrest at the S phase in the MCF-7 and MDA-MB-231 cell lines.
Conclusion
These findings showed that hesperidin is a potential therapeutic candidate for preventing the progression of breast cancer. In addition, hesperidin could significantly stimulate the death mechanisms in ER/PR (+) MCF-7 cells by changing the expression balance of Bax and Bcl-2 proteins, but lead ER/PR (-) MDA-MB-231 breast cancer cells to apoptosis in a different way.
How Personality Influences Health Outcomes and Quality of Life in Adult Patients with Cystic Fibrosis
Authors: Niehammer Ute , Straßburg Svenja , Sutharsan Sivagurunathan , Taube Christian , Welsner Matthias , Stehling Florian , Hirtz Raphael 
Published: January 2023

Abstract
Background: The present study evaluates personality traits in adult patients with cystic fibrosis (CF) and correlates these results with health-related quality of life (HRQoL) and other clinical parameters indicative of disease severity.
Methods: Seventy adults completed the Cystic Fibrosis Questionnaire-Revised (CFQ-R +14), a CF-specific measure of HRQoL, and a self-administered questionnaire about personality traits and disorders. Mean subscale scores and the prevalence of extreme personality traits on the `Persönlichkeits-Stil- und Störungs-Inventar (PSSI)´ were compared to the norming sample. Moreover, a cluster analysis was conducted to identify personality styles among people with cystic fibrosis (pwCF). The relationship between mean PSSI subscale scores and personality clusters with HRQoL and clinical outcomes, e.g., percent predicted forced expiratory volume in one second (ppFEV1), and body mass index (BMI), was studied by regression analysis considering important confounders.
Results: On several of the subscales of the personality questionnaire, people with cystic fibrosis (pwCF) showed either significantly higher or lower scores than the norm sample. In further analyses, two personality clusters could be identified. PwCF from the cluster with predominantly low scores on the subscales `negativistic´, `schizoid´, `borderline´, `depressed´, and `paranoid´ showed better HRQoL than pwCF from the other cluster with mainly high normal or elevated scores. The studied health outcomes proved to be independent of the respective personality clusters.
Conclusions: In pwCF, HRQoL is mainly determined by psychological factors, including personality. Since more recent personality theories assume that personality is modifiable, our findings imply that patients with accentuated personality traits may benefit from psychosocial support.
The prognostic value of the NECPAL instrument, Palliative Prognostic Index, and PROFUND index in elderly residents of nursing homes with advanced chronic condition
Authors: Esteban-Burgos Ana Alejandra , Hueso-Montoro César , Mota-Romero Emilio , Montoya-Juárez Rafael , Gómez-Batiste Xavier , García-Caro María Paz 
Published: January 2023

Abstract

Background: It is essential to assess the need for palliative care and the life prognosis of elderly nursing home residents with an advanced chronic condition, and the NECPAL ICO-CCOMS©4.0 prognostic instrument may be adequate for both purposes. The objective of this study was to examine the predictive capacity of NECPAL, the Palliative Prognosis Index, and the PROFUND index in elderly residents with advanced chronic condition with and without dementia, comparing their results at different time points.
Methods: This prospective observational study was undertaken in eight nursing homes, following the survival of 146 residents with advanced chronic condition (46.6% with dementia) at 3, 6, 12, and 24 months. The capacity of the three instruments to predict mortality was evaluated by calculating the area under the receiver operating characteristic curve (AUC), with 95% confidence interval, for the global population and separately for residents with and without dementia. Results: The mean age of residents was 84.63 years (±8.989 yrs); 67.8% were female. The highest predictive capacity was found for PROFUND at 3 months (95%CI: 0.526-0.756; p=0.016), for PROFUND and NECPAL at 12 months (non-significant; AUC >0.5), and NECPAL at 24 months (close-to-significant (AUC=0.624; 95% CI: 0.499-0.750; p=0.053). The highest capacity at 12 months was obtained using PROFUND in residents with dementia (AUC=0.698; 95%CI: 0.566-0.829; p=0.003) and NECPAL in residents without dementia (non-significant; AUC=0.649; 95%CI: 0.432-0.867; p=0.178). Significant differences in AUC values were observed between PROFUND at 12 (p=0.017) and 24 (p=0.028) months. Conclusions: PROFUND offers the most accurate prediction of survival in elderly care home residents with advanced chronic condition overall and in those with dementia, especially over the short term, whereas NECPAL ICO-CCOMS©4.0 appears to be the most useful to predict the long-term survival of residents without dementia. These results support early evaluation of the need for palliative care in elderly care home residents with advanced chronic condition.