bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal stability and responsiveness of a conditioned pain modulation test
Authors: Bakken Anders Galaasen , Axén Iben , Eklund Andreas , Warnqvist Anna , O’Neill Søren 
Published: March 2023

Abstract

Objectives
Conditioned pain modulation is a commonly used quantitative sensory test, measuring endogenous pain control. The temporal stability of the test is questioned, and there is a lack of agreement on the effect of different pain conditions on the conditioned pain modulation response. Thus, an investigation of the temporal stability of a conditioned pain modulation test among patients suffering from persistent or recurrent neck pain is warranted. Further, an investigation into the difference between patients experiencing a clinically important improvement in pain and those not experiencing such an improvement will aid the understanding between changes in pain and the stability of the conditioned pain modulation test.

Methods
This study is based on a randomized controlled trial investigating the effect of home stretching exercises and spinal manipulative therapy vs. home stretching exercises alone. As no difference was found between the interventions, all participants were studied as a prospective cohort in this study, investigating the temporal stability of a conditioned pain modulation test. The cohort was also divided into responders with a minimally clinically important improvement in pain and those not experiencing such an improvement.

Results
Stable measurements of conditioned pain modulation were observed for all independent variables, with a mean change in individual CPM responses of 0.22 from baseline to one week with a standard deviation of 1.34, and −0.15 from the first to the second week with a standard deviation of 1.23. An Intraclass Correlation Coefficient (ICC3 – single, fixed rater) for CPM across the three time points yielded a coefficient of 0.54 (p<0.001).

Conclusions
Patients with persistent or recurrent neck pain had stable CPM responses over a 2 week course of treatment irrespective of clinical response.
El horror en la literatura
Authors: González Grueso Fernando Darío 
Published: March 2023

A partir del ensayo “Supernatural Horror in Literature”, de H. P. Lovecraft, hemos construido un modelo descriptivo coherente del género literario del horror con sus relaciones internas y externas, y que bien podría servir de punto de partida para posibles ampliaciones. Para ello, hemos cotejado, revisado y desarrollado determinados conceptos de los estudios clave sobre el miedo, desde Aristóteles hasta los más recientes acercamientos, pasando por Radcliffe, Freud, Delumeau, Kristeva, Carroll, y Jackson, entre otros, y hemos determinado las diferencias entre dos géneros tan cercanos como el terror y el horror. El presente artículo analizará diversos acercamientos teóricos al respecto, que van desde la historia de la literatura, al psicoanálisis, la psicología y la teoría literaria, buscará puntos en común y desarrollará conceptos teóricos clave para la demarcación del genero del horror, y que es, desde hace tiempo, un género perfectamente delimitado.
Analisa Hubungan Bilateral Pakistan-Afghanistan Pasca Pemerintahan Taliban
Authors: Nurdin Ikhsan None , Aldiniansyah Muslich Ananda Maulana , Salsabila Syahdani None 
Published: March 2023

Artikel ini membahas tentang perkembangan hubungan bilateral Pakistan dengan Afghanistan setelah pemerintahan Taliban. Hal ini menunjukkan bahwa perkembangan hubungan bilateral antara kedua negara tersebut berjalan lancar atau membaik seiring dengan berjalannya waktu, entah itu dari perkembangan ekonomi maupun sosial politik kedua belah negara tersebut. Pakistan mendukung dalam pembangunan pemerintahan dan kekuasaan Taliban di Afghanistan akantetapi mereka juga membuat kebijakan tersendiri untuk menyikapi hal tersebut. Artikel ini menggunakan metode penelitian kuantitatif dengan cara pengambilan sumber sumber dari berbagai jurnal dan penelitian sebelumnya, yang memiliki hasil akhir yaitu bahwasannya hubungan bilateral antara kedua negara tersebut pasca pemerintahan Taliban memiliki beberapa kemajuan di berbagai bidang sehingga faktor tersebut dapat meningkatkan perkembangan di negara Afghanistan itu sendiri. Kata Kunci : Hubungan Bilateral, Pemerintahan Taliban, Pakistan-Afghanistan
Filsafat Hukum Sejarah: Konsep dan Aktualisasinya Dalam Hukum Indonesia
Authors: Rahmatullah Indra 
Published: March 2023

Abstract: Society has own legal system, namely customary law which can be a source of national law. It exists and has been legitimized in the Indonesian constitution. With the recognition of customary law, law enforcers and lawmakers must consider it. Customary law is not made by the State, but exists, and develops with the development of society. In certain areas, the application of customary law or compliance with customary law is more binding than state law. The basic concept of customary law is from the thought of Friedrick Karl von Savigny through his various works, thus making him the philosopher who built the foundation for the School of Legal History. Keywords: Society; Customary Law; Legal History
ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis
Authors: Yang Xin , Lu Liqun , Wu Chan , Zhang Feng 
Published: March 2023

Background: Sepsis is a life-threatening disease with dominant mortality. Its early diagnosis and treatment can improve prognosis and reduce mortality. Long noncoding RNAs (lncRNAs) ATPase plasma membrane Ca2+ transporting 1 antisense RNA 1 (ATP2B1-AS1) is dysregulated and is involved in the progression of various diseases. Nevertheless, the role of ATP2B1-AS1 in sepsis remains unclear.
Methods: A human monocytic cell line, THP-1 cells, was stimulated to induce a model of sepsis in vitro. The levels of ATP2B1-AS1, miR-23a-3p, and TLR4 were assessed by real-time quantitative polymerase chain reaction. The role of ATP2B1-AS1 in cell apoptosis and inflammation was explored by flow cytometry, Western blot analysis and enzyme-linked immunosorbent serologic assay. The binding sites between ATP2B1-AS1 and miR-23a-3p, and between miR-23a-3p and TLR4 were predicted by BiBiServ and the Encyclopedia of RNA Interactomes (ENCORI) online sites, respectively, and confirmed by the luciferase assay.
Results: The level of ATP2B1-AS1 was increased in lipopolysaccharide (LPS)-treated THP-1 cells. LPS increased apoptosis ratio, relative protein expressions of pro-apoptotic factors, and relative messenger RNA (mRNA) level and concentrations of pro-inflammatory cytokines, but decreased the relative expression of anti-apoptosis protein and relative mRNA level and concentrations of anti-inflammatory factor. All these alterations were reversed with transfection of shATP2B1-AS1 into THP-1 cells. Moreover, ATP2B1-AS1 directly bound miR-23a-3p and negatively modulated the level of miR-23a-3p. Meanwhile, TLR4 was directly targeted by miR-23a-3p, and negatively and positively modulated by miR-23a-3p and ATP2B1-AS1, respectively.
Conclusion: ATP2B1-AS1 aggravated apoptosis and inflammation by modulating miR-23a-3p/TLR4 axis in LPS-treated THP-1 cells.
Teaching Forensic Social Work: Innovative Education through Service-Learning
Authors: Eaton-Stull Yvonne , Potts Noelle , Pridgen Serena , Farren Doris 
Published: March 2023

The high impact, experiential education of service-learning was utilized in a Forensic Social Work class to enhance students’ social work skills. Students and faculty, along with another community partner provided animal-assisted grief support groups to individuals who were incarcerated. Two support groups were provided to individuals who suffered a recent or unresolved loss, one with women and one with men. Social work skills of empathy, professional boundaries, social justice, group facilitation, and applying theory to practice were greatly enhanced through this service-learning, high impact practice. The added value of therapy dogs in enhancing the therapeutic process was also noted.
The Sticky Riff: Quantifying the Melodic Identities of Medieval Modes
Authors: Helsen Kate , Daley Mark , Schindler Jake 
Published: March 2023

Andrew Hughes' Late Medieval Liturgical Offices afforded chant scholarship more melodies than it knew what to do with. Until now, chant scholarship involving 'Big Data' usually meant comparing individual feasts to the whole corpus or looking at general trends with respect to 'word painting' or stereotyped cadences. New research presented here, using n-gram analysis, networks, and Recurrent Neural Networks (RNN) looks to the nature of the gestural components of the melodies themselves. By isolating the notes preceding, and proceeding from, the naturally occurring semitones in the medieval church modes, we find significant recurrence of particular phrases, or riffs, which we propose could have been used to help 'build modes' from the inside out. Special care needed to be brought to the question of assumed B-flats that were not given explicitly in the manuscripts represented in Hughes' work. Understanding modes not as 'scales' but as a collection of associated smaller musical gestures, has resulted in a set of recurring riffs that appear as the identifiers of their larger contexts and confirming the influence of an earlier, oral / aural culture on these late medieval chants where musical literacy was expected.
Special Issue on Application of Artificial Intelligence Techniques in Production Engineering
Authors: Nakamoto Keiichi , Takasugi Keigo 
Published: March 2023

Artificial intelligence (AI) techniques have been behind disruptive innovations in every industry. Based on AI techniques, large amounts of data can be converted into actionable insights and predictions. Manufacturers have frequently faced different kinds of challenges, such as unexpected machinery failures or defective product deliveries. Still, the adoption of AI techniques is expected to improve operational efficiency, enable the launch of new products, customize product designs, and plan future financial actions. Recently, manufacturers have been using AI techniques to improve the quality of their products, achieve greater speed and visibility across supply chains, and optimize inventory management.
Given that the attention and interest in AI techniques has been growing rapidly, it is time that the current state of the art of their practical applications be presented. The main aim of this special issue is to bring together the latest AI research and practical case studies of AI techniques in production engineering.
This special issue features 10 papers related to not only operation automation but also sophisticated skill transfer in manufacturers. Their subjects cover various advancements, such as failure diagnosis, product estimation, process planning, operation planning, and workpiece fixturing in the area of machining. Moreover, the authors boldly strive to apply AI technologies even to complex systems in manufacturing fields such as laser-assisted incremental forming, injection molded direct joining, and parts assembling.
We thank the authors for their interesting papers submitted for this special issue, and we are sure that both general readers and specialists will find the information the authors provide both interesting and informative. Moreover, we deeply appreciate the reviewers for their incisive efforts. Without these contributions, this special issue would not have been possible. We truly hope that this special issue triggers further research on AI techniques in production engineering.
Development of Biology Module Based on Critical Thinking Skills on Even Semester Class X Plante Materials
Authors: Fadillah Etty Nurmala , Dewiyeti Susi , Yuliani Dwi , Fikri Achmad Ali 
Published: March 2023

<p>The purpose of this study is: to see the characteristics, feasibility, and practicality of the development of biology modules based on critical thinking skills grade x Plantae material. Modules developed based on the 4-D development model proposed by Thiagarajan are define, design, develop, and disseminate. The product validation was carried out by four validation professors and three biology teachers at SMA Negeri 4 Palembang as practitioners. Limited trials conducted by 15 students in grade x. Data analysis techniques using qualitative descriptive analysis using formulas from Aiken’s V and azwar formulas in excel. The results of the study are as follows: (1) the characteristics of the modules developed are printed using A4 paper. The module consists of a cover, title page, identity page, preface, table of contents, list of pictures, list of tables, instructions for using the module, indicators of critical thinking skills, matter of activities, Plantae material, exercises, summaries, self-reflection, bibliography, glossary , and answer guidelines; (2) biology module based on critical thinking skills on even semester grade X Plantae material is said to be very feasible in terms of the validation results; and (3) the results of practical responses by students when in the field are stated with very practical criteria.</p><p class="Default"> </p><p class="Default"><strong>Keywords</strong>: biology module, critical thinking skills, Plantae</p>
Mediation Role in Solving Sharia Economic Dispute as Civilization Toward Ethical Value of Islam
Authors: Santoso Santoso 
Published: March 2023

<p>The aim of this study is to explain the role of mediation in solving sharia economy dispute as civilization toward ethical value of Islam. That it has been practiced since Rasulullah SAW era was through many ways such as shulh, tahkim, and qadha. This study uses qualitative method and data collection is got from observation, direct interview to justice, attorney, lawyer, mediator, and the disputants. Based on the result of the study above is known that the role of mediation in solving sharia economy dispute as civilization toward ethical value of Islam is important and needs to be optimalized. According to Rasulullah SAW teaching, in fact, in a practice, there is failure of mediation in solving sharia economy dispute because the disputants feel that they are right and want to win finally by litigation way with consent or default judgment. Otherwise, mediation practice gives benefits for the disputants and based on Indonesian culture and civilization because solving dispute through mediation can be solved fast, correctly, and cheaply, thus it does not take much energy, time, and thought. In a result, it can keep privacy, beneficial for parties, and harmless with the result made by parties themselves, that is “win-win solution”. In ethical value of Islam in solving sharia economic dispute, firstly, by al-shulh (peace). Peace in islam is recommended because if there is peace among disputants, they will avoid from hostility. If it does not work, it can be passed by al-tahkim (arbitration) and if it gets stuck, Islam teaches us by al-qadha (Court Process).</p>
Gartland Type III Pediatric Supracondylar Humerus Fracture with Radial Nerve Laceration
Authors: Ito Rina , Otsuka Junko , Horii Emiko , Koh Shukuki 
Published: March 2023

Case:
A 6-year-old boy sustained complete radial nerve palsy with a Gartland type III supracondylar humerus fracture (SCHF). Posteromedial displacement of the distal fragment was so severe that the tip of the proximal fragment protruded subcutaneously at the anterolateral aspect of the antecubital fossa. Immediate surgical exploration was performed to reveal radial nerve laceration. Neurorrhaphy after fixation of the fracture resulted in full recovery of radial nerve function 1 year postoperatively.

Conclusions:
Severe posteromedial displacement with complete radial nerve palsy may warrant acute surgical exploration even in a closed SCHF because primary neurorrhaphy may achieve better results than late reconstruction.
Asthma Control in Multimorbid Patients
Authors: Tribuntseva Ludmila , Budnevsky Andrey , Prozorova Galina , Kozhevnikova Svetlana , Olysheva Irina , Ovsyannikov Evgeniy , Chernik Tatiana 
Published: March 2023

Background: The aim of this study was to evaluate the asthma control in multimorbid patients to personalize asthma treatment. Methods and Results: The study involved 237 asthma patients (51 men and 186 women) aged 18 to 78 years (mean age of 52.6±1.3 years). All patients were divided into 3 groups: Group 1 included 59(24.9%) patients with normal body weight (NVW), Group 2 included 69(29.1%) overweight patients, and Group 3 had 109(46.0%) obese patients. The mean BMI was of 23.14±2.84 kg/m2, 27.60±2.58 kg/m2, and 35.82±10.23 kg/m2 in Groups 1, 2, and 3, respectively (F=65.572, P=0.0000). Research methods included numerical rating scale (NRS) for a qualitative assessment of the severity of asthma clinical symptoms, asthma control questionnaire (ACQ-5) to assess asthma control, asthma quality of life questionnaire (AQLQ). Comorbidities were analyzed according to medical records.	The mean number of comorbidities among all studied patients was 4.31±0.27: 55(23.2%) people had ≤2 comorbidities, 118(49.8%) people had 3-5 comorbidities, and 64(27.0%) people had ≥6 comorbidities. The Group 3 patients had significantly more comorbidities than patients of Groups 1 and 2 (P=0.000). The mean value of the ACQ-5 results was 0.97±0.32, 1.06±0.53, and 1.82±0.55 in Groups 1, 2, and 3, respectively (F=77.1896, P=0.0000). The level of AC, according to the ACQ-5, had a positive correlation with the number of comorbidities (r=0.5418, P<0.05) and a negative correlation with all scales of the AQLQ: activity limitation (r=-0.6376, P<0.05), symptoms (r=-0.6577, P<0.05); emotional function (r=-0.4535, P<0.05); environmental stimuli (r=-0.4529, P<0.05), and general QOL (r=-0.6504, P<0.05).	The asthma course is negatively affected by multimorbidity, which is most pronounced in obese patients. An increase in the number of comorbidities significantly worsens AC in patients of all studied groups, while the worst control level was observed in obese patients. A personalized program for managing multimorbid asthma patients should be developed and implemented, considering the multivariate assessment of treatable signs of disease.
Cost-effectiveness of Syphilis Screening in Pregnant Women: A Literature System Review
Authors: Zhang Meng , Zhang Hongyan , Hui Xiaoqing , Qu Huiming , Xia Junfen , Xu Feng , Shi Cannan , He Junjian , Cao Yuan , Hu Mengcai 
Published: March 2023

Abstract
The cost-effectiveness study of syphilis screening in pregnant women has not been synthesized. The aim of this study is to synthesizes the economic evidence of the cost-effectiveness of syphilis screening in pregnant women which might contribute to make recommendations on future direction of syphilis screening approaches. We systematically search Medline, PubMed and Web of Science for relevant studies published before May 19th 2022 and identified cost-effectiveness analysis for syphilis screening in pregnant women. The methodological design quality was appraised by Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 checklist. Seventeen literature met the eligibility criteria for full review. Of the seventeen studies, four studies evaluated interventions using different screening methods, seven studies assessed the combination of syphilis test and treatment interventions, three studies focused on repeat screening intervention and four studies evaluated the intervention integrated syphilis and HIV test. The most cost-effective strategy appeared to be rapid syphilis tests with high treatment rate of the positive pregnant women. The cost-effectiveness of syphilis screening in pregnancy has been widely demonstrated. It is more important to improve the compliance of maternal screening and the treatment rate of positive pregnant women while implementing screening.
A Multi-Directional Analysis of the Center of Resistance using Finite Element Model of the Human Mandibular Canine
Authors: Kamali Elaheh , Geramy Amirreza , Geramy Allahyar 
Published: March 2023

Abstract
Background
The most important factor determining the quality of orthodontic tooth movement is the relationship between the force and the tooth center of resistance. Tooth supporting structures features affect the center of resistance location and these features varies in different areas around the specific tooth. So the aim of this study is the multi-planar analysis of the center of resistance using finite element models of the human mandibular canine to find the exact location of the center of resistance when viewed from different aspects.
Method
The left mandibular canine, periodontal ligament, cortical bone and spongy bone designed in Soidwork (version 2021) according to a contralateral canine with a complete eruption in a case with an impacted canine which has been ordered for CBCT. the tooth dimension was slightly modified according to wheelers dental anatomy. The meshed model was created. A 1N.mm couple was applied to the model and the center of resistance was evaluated from different 24 planes with 15 degrees intervals.
Results
The location of human mandibular center of resistance is different in horizontal plane when evaluated in different directions. It is in the range of 46–86% of canine root length from the apex and moves up to 4.48 millimeters occlusogingivally. In the buccal or lingual directions CRes location was found more apical than its mesial or distal counterparts.
Conclusions
the location of the CRes changes when evaluated in different directions related to supporting tissue features. It can therefore be concluded that canine requires a higher M/F for buccolingual translation than for a mesiodistal translation
Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS
Authors: Mora Santiago , Friis Rasmus von Huth , Stuckert Anna , Noes-Holt Gith , Montañana-Rosell Roser , Sørensen Andreas , Selvan Raghavendra , Allodi Ilary 
Published: March 2023

Abstract

Loss of connectivity between spinal V1 inhibitory interneurons and motor neurons is found early in disease in the SOD1G93A mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of a presynaptic organizer, increases motor neuron survival and ameliorates motor phenotype, demonstrating that interneurons can be a potential target to attenuate ALS symptoms.