bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Situ Artificial Hybrid SEI Layer Enabled High‐Performance Prelithiated SiOx Anode for Lithium‐Ion Batteries
Authors: Sun Yi , Zhang Kuanxin , Chai Run , Wang Yueda , Rui Xianhong , Wang Kang , Deng Huaxia , Xiang Hongfa 
Published: May 2023

AbstractConsidered the promising anode material for next‐generation high‐energy lithium‐ion batteries, SiOx has been slow to commercialize due to its low initial Coulombic efficiency (ICE) and unstable solid electrolyte interface (SEI) layer, which leads to reduced full‐cell energy density, short cycling lives, and poor rate performance. Herein, a novel strategy is proposed to in situ construct an artificial hybrid SEI layer consisting of LiF and Li3Sb on a prelithiated SiOx anode via spontaneous chemical reaction with SbF3. In addition to the increasing ICE (94.5%), the preformed artificial SEI layer with long‐term cycle stability and enhanced Li+ transport capability enables a remarkable improvement in capacity retention and rate capability for modified SiOx. Furthermore, the full cell using Li(Ni0.8Co0.1Mn0.1)O2 and a pre‐treated anode exhibits high ICE (86.0%) and capacity retention (86.6%) after 100 cycles at 0.5 C. This study provides a fresh insight into how to obtain stable interface on a prelithiated SiOx anode for high energy and long lifespan lithium‐ion batteries.
Biomimetic Liquid Metal Mechatronic Devices
Authors: Wang Yushu , Chang Hao , Wang Shengnan , Wang Dawei , Xue Mianqi , Liu Jing , Rao Wei 
Published: May 2023

AbstractPerceiving mechanical stimuli and converting them into bioelectric signals to complete sensing information transmission and computation is a fundamental mechanism for survival and evolution of natural animals. This leads to a variety of intelligent behaviors, such as processing, learning, judgment, feedback, and so on when tackling complex and changeable environmental challenges. Until now, the realization of a bionic system to mimic the above activities has long been an important goal which is mainly based on the integration of distributed functional units, lacking the coordination between functional units and the whole systems. Herein, based on the mechano‐electronic coupling effect of liquid metals and by following the basic principle of perception and transduction of piezo proteins, a biomimetic functional liquid metal mechatronic device is proposed with the switching behavior via establishing the reversible charge gradient. Owing to flexible features of liquid metals, this all‐soft mechatronic device exhibits excellent compliance with the whole system. Based on electrochemical characteristics of liquid metals, the passive intelligent device demonstrates versatile behaviors, such as self‐energy supply, encoding, computation, sensing, information identification, communicating, and controlling functions etc. which can only possibly be achieved by living animals. This work opens a new strategy for developing intelligent mechatronic systems.
Scalable Synthesis of High‐Quality Core/Shell Quantum Dots With Suppressed Blinking
Authors: Tao Chen‐Lei , Ma Jinling , Wei Changting , Xu Dan , Xie Zhuoyi , Jiang Zhengfei , Ge Feiyue , Zhang Han , Xie Mingcai , Ye Zhiliang , Cheng Fang , Xu Bo , Tian Yuxi , Wu Xue‐Jun 
Published: May 2023

AbstractA facile and reproducible method for scalable synthesis of high‐quality core/shell quantum dots (QDs) is a prerequisite to facilitate their versatile applications. Herein, a seed‐mediated heat‐up approach is developed for the preparation of high‐quality core/shell QDs with variable shell composition and continuously tunable shell thickness by selection of conventional salts as the precursors. The method is very simple and highly reproducible and, therefore, can be easily scaled up to get gram‐level product. The as‐obtained CdSe/CdS and CdSe/ZnCdS core/shell QDs exhibit intriguing optical properties, that is a narrow photoluminescence (PL) emission peak and near‐unity PL quantum yield. Importantly, the CdSe/ZnCdS core/shell QDs with a size of 11.4 nm exhibit obviously suppressed blinking behavior, and the fraction of nonblinking QDs (defined by an on‐time fraction ≥ 0.95) can reach as high as 96.0% on the measurement of more than 200 QDs. Moreover, quantum‐dot light‐emitting diodes (QLEDs) based on CdSe/ZnCdS core/shell QDs show a peak external quantum efficiency of 14.8% and low efficiency roll‐off at luminance ranging from 1000 to 25 000 cd·m−2. It is anticipated that the presented work will pave a novel way for the large‐scale production of high‐quality QDs and further boost their applications in light‐emitting diodes, lasing, and biological imaging.
CD44 and HAP‐Conjugated hADSCs as Living Materials for Targeted Tumor Therapy and Bone Regeneration
Authors: Xia He , Hao Min , Li Kaiwen , Chen Xin , Yu Liyang , Qiu Jichuan , Zhang Hongyu , Li Haijun , Sang Yuanhua , Liu Hong 
Published: May 2023

AbstractCombining targeted tumor therapy with tissue regeneration represents a promising strategy for synergistic tumor therapy. In this study, a multifunctional living material is constructed with human‐derived adipose stem cells (hADSCs) and antibody‐modified hydroxyapatite nanorods (nHAP) for targeted drug delivery and bone regeneration following surgery. The living material delivers the therapeutics to the tumor site efficiently based on the strength of the inherent tumor tropism of hADSCs. The bioconjugation of nHAP with hADSCs via specific antibody modification is found to be biocompatible, even when loaded with the chemotherapeutic drug doxorubicin (Dox). The endocytosis of nHAP stimulates the osteogenic differentiation of hADSCs, promoting bone tissue regeneration. Moreover, the antibody‐modified nHAP‐hADSC conjugate exhibits targeted tumor delivery, which is further facilitated by pH‐triggered release of Dox, inducing apoptosis of tumor cells with low toxicity to healthy tissues. Therefore, the present study provides a general strategy for engineering living materials to achieve targeted tumor therapy and bone tissue regeneration after surgery, which can be extended to other disease types.
Prevalent stroke, age of its onset, and post‐stroke lifestyle in relation to dementia: A prospective cohort study
Authors: Zhong Wansi , Chen Hui , Gong Xiaoxian , Tong Lusha , Xu Xin , Zong Geng , Yuan Changzheng , Lou Min 
Published: May 2023

AbstractINTRODUCTIONThe association of age at stroke onset with dementia and the role of post‐stroke lifestyle on dementia risk remains unclear.METHODSWe leveraged data of 496,251 dementia‐free participants from UK Biobank and explored the relationship between age at stroke onset and incident dementia. Among 8328 participants with stroke history, we further investigated the association of a healthy lifestyle with risk of dementia.RESULTSParticipants with stroke history had a higher risk of dementia (hazard ratio [HR], 2.02). The association was stronger among participants with stroke onset at a younger age (≤50: HR, 2.63) compared with those at the age > 50 years (50–60: HR, 2.17; ≥60: HR, 1.58). Among participants with stroke history, a favorable lifestyle was associated with a lower risk of incident dementia.DISCUSSIONStroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post‐stroke lifestyle may protect against dementia.
Blue light transurethral resection and biopsy of bladder cancer with hexaminolevulinate: Histopathological characteristics and recurrence rates in a single UK centre study
Authors: Chan Kimberley , Hampson Alexander , Hayes John , Rabinowitz Joshua , Vasdev Nikhil 
Published: May 2023

AbstractIntroductionBlue light cystoscopy with hexaminolevulinate (HAL) during transurethral resection of bladder cancer (TURBT) has been shown to improve detection, thereby reducing bladder cancer recurrence compared with white light cystoscopy.MethodsSingle‐centred UK (United Kingdom) study on 101 patients who underwent blue light cystoscopy between July 2017 and November 2020, performed by a single surgeon. Our study was divided into two arms; the primary arm had no prior diagnosis of bladder malignancy (N = 41), whereas secondary re‐resection arm had (N = 57). Three patients with non‐urothelial bladder cancer were excluded. Patients were followed up for 24 months. Data were collected on biopsy quality, histopathological characteristics and recurrence. The end points of the study were recurrence rate at 24 months in both arms and detection of CIS in patients who undergo TURBT or biopsy after initial white light study in the secondary, re‐resection arm. This was analysed with Fisher's exact test.ResultsOf 98 patients, 39 had malignancy in their first blue light TURBT/biopsy: primary arm (10/41, 24.4%) and secondary arm (29/57, 50.9%), with detrusor present in 80.5% and 80.7%, respectively. In the secondary arm, blue light re‐resection TURBT detected significantly more CIS (20.7% vs 51.7%, p = 0.0277) compared with white light with 3.4% upstaged to muscle invasive bladder cancer (G3pT2). Median time to re‐resection was 3.06 months. Recurrence rate was 33.3% in the primary arm and 37.5% in the secondary arm after 24 months of follow‐up.ConclusionOur data confirm that blue light TURBT with HAL provides superior detection and diagnosis of CIS in patients with previous white light cystoscopy.
The effect of thioredoxin‐1 in a rat model of traumatic brain injury depending on diurnal variation
Authors: Noriega‐Navarro Roxana , Martínez‐Tapia Ricardo Jesús , González‐Rivera Rubén , Ochoa‐Sánchez Alicia , Abarca‐Magaña Julio César , Landa‐Navarro Lucía , Rodríguez‐Mata Verónica , Ugalde‐Muñiz Perla , Pérez‐Torres Armando , Landa Abraham , Navarro Luz 
Published: May 2023

AbstractIntroductionTraumatic brain injury (TBI) is a public health concern with limited treatment options because it causes a cascade of side effects that are the leading cause of hospital death. Thioredoxin is an enzyme with neuroprotective properties such as antioxidant, antiapoptotic, immune response modulator, and neurogenic, among others; it has been considered a therapeutic target for treating many disorders.MethodsThe controlled cortical impact (CCI) model was used to assess the effect of recombinant human thioredoxin 1 (rhTrx1) (1 μg/2 μL, intracortical) on rats subjected to TBI at two different times of the light‐dark cycle (01:00 and 13:00 h). We analyzed the food intake, body weight loss, motor coordination, pain perception, and histology in specific hippocampus (CA1, CA2, CA3, and Dental Gyrus) and striatum (caudate‐putamen) areas.ResultsBody weight loss, reduced food intake, spontaneous pain, motor impairment, and neuronal damage in specific hippocampus and striatum regions are more evident in rats subjected to TBI in the light phase than in the dark phase of the cycle and in groups that did not receive rhTrx1 or minocycline (as positive control). Three days after TBI, there is a recovery in body weight, food intake, motor impairment, and pain, which is more pronounced in the rats subjected to TBI at the dark phase of the cycle and those that received rhTrx1 or minocycline.ConclusionsKnowing the time of day a TBI occurs in connection to the neuroprotective mechanisms of the immune response in diurnal variation and the usage of the Trx1 protein might have a beneficial therapeutic impact in promoting quick recovery after a TBI.
Altered resting‐state hippocampal functional connectivity in breast cancer survivors with chemotherapy‐induced amenorrhea
Authors: Zhuang Yingying , Guo Lili , Huang Wei , Bo Genji , Zhang Jiandong , Zhu Zhaohuan , Feng Yun 
Published: May 2023

AbstractIntroductionAmenorrhea induced decrease of hormones is associated with cognitive impairment. This study aimed to evaluate hippocampal functional connectivity patterns in chemotherapy‐induced amenorrhea (CIA) breast cancer (BC) patients, to evaluate the relationship between the functional connectivity features and hormone levels.MethodNeuropsychological test, functional magnetic resonance imaging, and assessment of hormone levels were conducted in 21 premenopausal BC patients before chemotherapy (t0) and 1 week after completing chemotherapy (t1). Twenty matched healthy controls (HC) were also included and underwent the same assessments at similar time intervals. Mixed effect analysis and paired t‐test were used to compare differences in brain functional connectivity.ResultsVoxel‐based paired t‐tests revealed increased functional connectivity of the right and left hippocampus with the left fusiform gyrus, inferior and middle temporal gyrus, inferior occipital gyrus, left lingual gyrus, and parahippocampal gyrus after chemotherapy (p < .001) in CIA patients. Repeated measures analysis revealed significant group‐by‐time interactions in the left hippocampus with the bilateral fusiform gyrus, right parahippocampal gyrus, left inferior temporal gyrus, and left inferior occipital gyrus (p < .001). Premenopausal BC patients had no significant differences in cognitive function compared with HC at baseline. However, the CIA patients had high levels of self‐rating depression scale, self‐rating anxiety scale, total cholesterol, and triglycerides. Further, the CIA patients showed significant differences in hormone and fasting plasma glucose levels and cognitive performances between t0 and t1 (p < .05). Functional connectivity changes between the left hippocampus and the left inferior occipital gyrus was negatively correlated with E2 and luteinizing hormone changes (p < .05).ConclusionThe CIA patients had cognitive dysfunction mainly in memory and visual mobility. Chemotherapy may affect hippocampal‐posterior cortical circuit which mediates visual processing in CIA patients. Moreover, E2 may be involved in this process.
Total neoadjuvant treatment to increase the clinical complete response rate for distal locally advanced rectal cancer (TESS): A study protocol of a prospective, open‐label, multicenter, single‐arm, phase 2 trial
Authors: Liu Shuang , Wang XiaoZhong , Zhuang YeZhong , Bai ShouMin , Wu XiaoJun , Ye YiJing , Luo HuiLong , Yu HaiNa , Wang QiaoXuan , Chang Hui , Zeng ZhiFan , Cai PeiQiang , Pan ZhiZhong , Gao YuanHong , Chen Gong , Xiao WeiWei 
Published: May 2023

AbstractBackgroundStandard treatment of locally advanced rectal cancer (LARC) was neoadjuvant chemoradiotherapy (CRT), followed by total mesorectal excision (TME). Total neoadjuvant treatment (TNT), a new concept, attempts to deliver both systemic chemotherapy and neoadjuvant CRT prior to surgery. Patients treated with neoadjuvant chemotherapy were more likely to show higher tumor regression. The objective of this trial was to increase complete clinical rate (cCR) for LARC patients by optimizing tumor response, using TNT regimen as compared to conventional chemoradiotherapy. TESS, a prospective, open‐label, multicenter, single‐arm, phase 2 study, is underway.MethodsMain inclusion criteria include cT3‐4aNany or cT1‐4aN+ rectal adenocarcinoma aged 18‐70y; Eastern Cooperative Oncology Group (ECOG) performance 0–1; location ≤5 cm from anal verge. Ninety‐eight patients will receive 2 cycles of neoadjuvant chemotherapy Capeox (capecitabine + oxaliplatin) before, during, and after radiotherapy 50Gy/25 fractions, before TME (or other treatment decisions, such as Watch and Wait strategy) and adjuvant chemotherapy capecitabine 2 cycles. Primary endpoint is the cCR rate. Secondary endpoints include ratio of sphincter preservation strategy; pathological complete response rate and tumor regression grade distribution; local recurrence or metastasis; disease‐free survival; locoregional recurrence‐free survival; acute toxicity; surgical complications; long‐term anal function; late toxicity; adverse effect, ECOG standard score, and quality of life. Adverse events are graded per Common Terminology Criteria for Adverse Events V5.0. Acute toxicity will be monitored during antitumor treatment, and late toxicity will be monitored for 3 years from the end of the first course of antitumor treatment.DiscussionThe TESS trial aims to explore a new TNT strategy, which is expected to increase the rate of cCR and sphincter preservation rate. This study will provide new options and evidence for a new sandwich TNT strategy in patients with distal LARC.
Risk factor analysis of thymoma resection and its value in guiding clinical treatment
Authors: Du Xin , Cui Jian , Yu Xin‐tao , Yu Lei 
Published: May 2023

AbstractBackgroundIn this study, relationships between clinicopathologic characteristics and progression‐free survival (PFS) of patients after thymomectomy were analyzed to provide valuable suggestions regarding the treatment of thymoma.MethodsData from 187 thymoma patients undergoing surgery at Beijing Tongren Hospital between January 1, 2006, and December 31, 2015, were retrospectively reviewed. We explored the risk factors for PFS among sex, age, thymoma‐associated MG, completeness of resection, histologic type and TNM stage, and investigated their interrelationship.ResultsAmong the 187 patients, 18 patients (9.63%) had tumor recurrence/metastasis, and all of whom had in situ recurrence or pleural metastasis, and most of them (10 of 18 patients) had MG symptoms that reappeared or were aggravated. Fifteen patients (8.02%) died, and myasthenic crisis was a leading cause. Based on Cox regression analysis, only age (HR = 3.16; 95% CI: 1.44–6.91;p = 0.004) and the completeness of resection (HR = 9.03; 95% CI: 2.58–31.55;p = 0.001) were independent risk factors for PFS. Furthermore, we found that the completeness of resection was related to the histologic type (p = 0.009) and TNM stage (p < 0.001) by Fisher's exact test.ConclusionsThe results of this cohort study remind us that we should pay attention to the reappearance or aggravation of MG after thymoma resection, because it is the leading cause of death and may indicate tumor progression. Furthermore, completeness of resection was related to the histologic type and TNM stage, but it was the independent risk factors of thymoma. Therefore, R0 resection is critical to the prognosis of thymoma.
preHAZOP: Graph‐Based Safety Analysis for Early Integration into Automated Engineering Workflows
Authors: Oeing Jonas , Holtermann Tim , Welscher Wolfgang , Severins Christian , Vogel Marius , Kockmann Norbert 
Published: May 2023

AbstractThe increasing digitalization and standardization within the process industry lead to a high availability of digital, machine‐readable processes and plant descriptions. In particular, the publication of the DEXPI standard provides a digital representation of plant topologies including a complete description of all specifications. In early planning phases, this can be used as the basis for an automated safety assessment since digital availability significantly simplifies accessibility for smart search algorithms. This paper presents the preHAZOP search algorithm, which was developed to analyze P&IDs in DEXPI format and to detect safety‐critical deviations regarding their risk according to a classical HAZOP analysis. The preHAZOP is of particular interest in early process development stages and can be easily integrated into modern, digital engineering workflows.
Energierückgewinnung mit MTP‐fähigem Volumenexpander
Authors: Pilous Yannick , Humer Matthias 
Published: May 2023

AbstractIn einem gemeinsamen Projekt der Firmen Stumer, Avibia und Iotech wurde eine intelligente Dampfdruck‐Reduzierstation als Package Unit entwickelt, die hierbei abfallende Energie ins Stromnetz speist und sich dank einer standardisierten MTP‐Schnittstelle mit geringem Integrationsaufwand nachrüsten lässt.
Aus der Digitalisierung mit KI mehr Nutzen ziehen
Authors: Gandert Etwina , Oestreich Volker 
Published: May 2023

AbstractKI kann ein Schlüssel werden, um aus der Digitalisierung deutlich mehr Nutzen zu ziehen, als nur Sensordaten zu verwalten. Axel Lorenz, CEO Process Automation, Dr. Hartmut Klocker, Segment Lead Automation and Engineering Systems und Dr. Jürgen Spitzer, General Manager Measurement Intelligence, erläutern im Interview mit CITplus, wo und wie aus der Digitalisierung und dem Einsatz von KI ein Mehrwert für Prozesssteuerung und Instandhaltung zu ziehen ist, wie weit Siemens bei der Entwicklung von APL‐fähigen Geräten ist und welche Chancen 5G bieten kann.
Funktionale Sicherheit im digitalisierten Anlagenbau
Authors: Sieber Peter , Schäfer Bernd 
Published: May 2023

AbstractSichere, flexible und anwendungsspezifische Programmierlösungen für die Funktionale Sicherheit einer Prozessanlage können zu langen Entwicklungszykluszeit führen, wenn beispielsweise langwierige Prüfprozesse den Anlagenbau ausbremsen. Ein modularer Ansatz kann diesen Prozess beschleunigen. Hier zeigt sich der Nutzen der Digitalisierung.
Technologien für die Digitalisierung is in die Feldebene
Authors: Hennecke Andreas , Rauscher Benedikt 
Published: May 2023

AbstractIm Lebenszyklus einer Prozessanlage ermöglicht die Digitalisierung, Risiken zu minimieren, den Anlagenbau zu beschleunigen sowie Produktion und Qualität zu optimieren. Wesentliche Voraussetzung sind eine robuste Infrastruktur für das Feld der Prozessanlage sowie eine digitale Architektur und Beschreibung für alle Anlagenassets – und beides bestenfalls standardisiert.
Nachhaltigkeit beim Einkauf von Komponenten
Authors: Roloff Bernd , Hentschel Arne 
Published: May 2023

AbstractMilliardenschwere Investitionen sind für den Aufbau der Wasserstoffwirtschaft geplant, insbesondere in der Wasserstoffprozesskette vom Elektrolyseur bis zur Brennstoffzelle und darüber hinaus. Gerade hier sollte sich der Einkauf fragen, wie nachhaltig die eingesetzten Produkte sind. Die TA Roloff ist Hersteller von elektrischen Stellantrieben für Industriearmaturen und hat einen hohen Anspruch an die Nachhaltigkeit seiner Produkte.
Prüfaufwand reduzieren und systematische Fehler vermeiden
Authors: Rützel Christian 
Published: May 2023

AbstractDie wiederkehrende, manuelle Prüfung von SIL‐Sicherheitseinrichtungen ist aufwendig und fehleranfällig. Die Wiederholprüfung lässt sich mit der Kombination mit der Hima‐Sicherheitssteuerung HIMax und der Endress+Hauser Heartbeat Technology den Prüfprozess automatisieren. Das vermeidet systematische Fehler, verlängert die Anlagenlaufzeiten und reduziert den Prüfaufwand.
Photocatalytic Metal‐Free Radical Hydrosilylation for Polymer Functionalization†
Authors: Huang Zhujun , Liu Kaiwen , Liu Mingyuan , Yun Jie , Dong Jin , Chen Zhe , Xie Zhikang , Pan Xiangcheng 
Published: May 2023

Comprehensive SummaryPost‐modification of polymers offers a route to prepare functionalized polymers through efficient chemical reactions, and hydrosilylation is one of the most effective strategies. Silane‐functionalized polymers have found a wide range of potential applications, such as adhesives, rubbers, and drug delivery agents. For decades, the hydrosilylation for the post‐modification of polymers has typically used transition metals as catalysts. Metal‐free hydrosilylation strategies that can avoid metal residues in polymers are largely lacking in this field. Herein, we report the photocatalytic metal‐free radical hydrosilylation strategy for the post‐modification of polymers bearing pendant vinyl groups using the organic photocatalyst and hydrogen atom transfer (HAT) catalyst under blue light irradiation. We used monofunctional silanes to functionalize polymers and the bis(silane)s as crosslinkers to prepare crosslinked polymers.