bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Patriotas” de un “país hermoso”: sobre el encuentro con un paramilitar
Authors: Monroy Álvarez Silvia 
Published: January 2023

Aldo Civico, antropólogo de origen italiano, ha investigado fenómenos relacionados
con conflicto armado, procesos de paz, resolución de conflictos, insurgencia, terrorismo, desplazamiento interno, Derechos Humanos y violencia juvenil en lugares como Colombia, México y los Balcanes, y en la actualidad dirige el Centro para la Resolución de Conflictos Internacionales (CICR) de la Universidad de Columbia, publicó en Colombia “No divulgar hasta que los implicados estén muertos”. Las guerras de “Doblecero”, justamente cinco años después del asesinato de Carlos
Mauricio García Fernández, conocido como “Rodrigo Doblecero”.
On scaling of earthquake faults
Authors: Wang Jeen-Hwa , Ou San-San 
Published: January 2023

AbstractScaling relations among seismic moment, M0, average displacement, δ, rupture width, W, and rupture length, L, of earthquake faults are studied mainly using the data base of earthquake source parameters compiled by Wells and Coppersmith (1994). Results show that seismic moment scales with rupture length approximately as M0 ∼ L2; rupture width is independent of rupture length for large earthquakes; average displacement relates to rupture length approximately as δ ∼ L; and the average displacement is independent of rupture width. Consequently, the L-model proposed by Scholz (1982) is more appropriate than the W-model suggested by Romanowicz (1992) to describe the scaling of earthquake faults.
Source mechanism of an explosively induced mine collapse
Authors: Yang Xiaoning , W. Stump Brian , Scott Phillips W. 
Published: January 2023

Abstract
Mining explosions and collapses, in addition to earthquakes, may trigger the future Comprehensive Test Ban Treaty (CTBT) monitoring system. Many shallow, spontaneously occurring mine collapses have implosional source mechanisms that might provide a physical basis to discriminate them from explosions. In this study, an explosively induced mine collapse was investigated. The collapse occurred immediately after the support pillars of a 320-m-deep underground mine opening were destroyed by explosives. It had an Lg body-wave magnitude (mbLg) of 2.8. We analyzed free-surface ground-motion data (within 1200 m) from the collapse by waveform forward modeling and time-dependent source moment-tensor inversion. The results indicate that the source mechanism of the collapse can be represented by a horizontal opening and closing crack. The time functions of the diagonal source moment-tensor components are similar to that of a spall source accompanying an underground explosion. A unique source characteristic of the induced collapse is that, unlike spontaneous collapses, the induced collapse initiated as a tensile crack. Because of the initially expansive source characteristic, this kind of induced mine collapses may pose some difficulties to the seismic discrimination problem. Despite the similarities between the induced mine collapse and underground explosions, the collapse has a more band-limited source spectrum and seems to be more efficient in shear and surface-wave generation.
Inovasi Pembelajaran Berbasis Digital untuk Meningkatkan Hasil Belajar Siswa Sekolah Dasar
Authors: Lubis Syamsidah 
Published: January 2023

Abstract: This study aims to find out that Digital based Learning innovation can improve student learning outcomes as many previous studies have implemented or implemented digital based learning. The research method used is a library study of various existing books and journals. The method of collecting data is by reading various books and using the internet to find articles or journals from previous studies that are in accordance with the object of this research. As for the results of a literature review conducted from several journals, it is proven that implementing digital based learning can improve learning outcomes from various levels (elementary, junior high, high school and university. Learning innovations are carried out in the form of digital applications and game media (Kahoot, Digital Snakes and Ladders, quizizz games, kodig (digital comics) etc.
Abstrak: Penelitian ini bertujuan untuk mengetahui bahwa inovasi pembelajaran berbasis digital dapat meningkatkan hasil belajar siswa sebagaimana banyak penelitian sebelumnya yang telah mengimplementasikan atau menerapkan pembelajaran berbasis digital. Metode penelitian yang digunakan adalah studi pustaka (library research) dari berbagai buku dan jurnal yang ada. Metode pengumpulan data dengan membaca berbagai buku dan bantuan internet untuk mencari artikel atau jurnal dari penelitian terdahulu yang sesuai dengan objek penelitian ini. Adapun hasil dari kajian pustaka yang dilakuan dari beberapa jurnal terbukti dengan mengimplenasikan pembelajaran digital dapat meningkatkan hasil belajar dari berbagai level (SD, SMP, SMA dan Perguruan tinggi. Inovasi pembelajaran yang di lakukan berupa aplikasi digital dan media game (Kahoot, Ular tangga digital, game quizizz, Kodig (Komik digital) dll.
Clinical Efficacy and Tolerability of Antihypertensive Therapy with Single Pill Combinations of Telmisartan in Patients with Arterial Hypertension in Clinical Practice According to the ON TIME Observational Study
Authors: Ageev F. T. , Smirnova M. D. 
Published: January 2023

Aim. To assess the clinical outcomes and tolerability of antihypertensive therapy with single pill combinations (SPC) amlodipine + telmisartan and hydrochlorothiazide + telmisartan in clinical practice.Material and methods. Patients with hypertension of grade 1-3 (n=13647; 57.6% women; age 59.3±11.4 years) who received therapy with SPC amlodipine + telmisartan or hydrochlorothiazide + telmisartan were included in an observational multicenter study. Information on complaints, history, previous therapy, history of novel coronavirus infection (COVID-19) during the previous year was obtained. Also, measurement of height, body weight, waist circumference (WC) and hips (HC), office blood pressure (BP) three times with an interval of 4 weeks, completion of questionnaires of satisfaction with therapy using the Likert scale, and assessement of adherence to therapy according to the patient's opinion was performed.Results. A statistically significant decrease in systolic (SBP) and diastolic blood pressure (DBP) was found both in all patients and in the analysis of subgroups according to the grade of hypertension (p<0.001 between visits in all cases). The degree of BP reduction depended on baseline BP levels. The average decrease in SBP/DBP at the 3rd visit for the grade 1 hypertension was 24.5/14.6 mm Hg, for the grade 2 hypertension – 34.4/16.8 mmHg, for the grade 3 hypertension – 49.6/22.1 mmHg (p<0.001 between groups). Target levels of SBP (≤140 mmHg) and DBP (≤90 mmHg) were achieved in 95.3% and 98.1% of patients, respectively. Target levels of SBP (≤130 mmHg) and DBP (≤80 mmHg) were achieved in 74.9% and 78.2% of patients, respectively. WC decreased by 0.5%; HC – by 1.5%; body weight – by 0.42% (p<0.001 in all cases). Scores in patients with a history of COVID-19 did not differ from those in individuals without a history of COVID-19. There were no violations of the therapy regimen during the observation period in 94% of patients. Most doctors and patients were "satisfied" or "completely satisfied" with the clinical effect, convenience and tolerability of therapy. Adverse events occurred in 1.35% of patients.Conclusion. Therapy with SPC amlodipine + telmisartan or hydrochlorothiazide + telmisartan in clinical practice had a high antihypertensive efficacy and had an optimal safety profile. The efficacy of therapy did not depend on the initial grade of hypertension, as well as the past infection with COVID19. The results of the ON TIME study confirm the feasibility of using the SPC amlodipine + telmisartan and hydrochlorothiazide + telmisartan for a wide range of hypertensive patients.
The Influence of Business Location, Price, and Consumer Satisfaction on Buying Interest in Stores
Authors: Andani Retno , Oetarjo Mas 
Published: January 2023

In an effort to bring in new customers and also retain customers, it requires high buying interest from consumers who ultimately make purchasing decisions. There are several factors that must be considered by entrepreneurs in starting a business, namely to coincide with the selection of location, price, and consumer satisfaction. To find out that the location of the business affects the interest in buying in Pak Tris 5758 Stores. This research uses quantitative methods. Sampling in this study used incidental sampling methods in consumers of Pak Tris 5758 Stores, namely consumers who shop at Pak Tris 5758 Stores, with a total of 96 respondents. The data collection technique used is to use kuesioner. The data analysis technique in this study uses multiple linear regression through the SPSS Statistic program version 22. The results showed that Business Location (X1), Price (X2), and Consumer Satisfaction (X3) simultaneously affect Buying Interest (Y) in Pak Tris 5758 Stores. Business Location (X1) partially affects Buying Interest (Y), Price (X2) partially affects Buying Interest (Y) and Consumer Satisfaction (X3) partially affects Buying Interest (Y).
Topological Reorganization of Functional Hubs in Parkinson’s Disease Patients With Freezing of Gait.
Authors: Sreeniva Karthik , Bayram Ece , Zhuang Xiaowei , Longhurst Jason , Yang Zhengshi , Cordes Dietmar , Ritter Aaron , Caldwell Jessica , Cummings Jeffrey , Mari Zoltan , Litvan Irene , Bluett Brent , Mishra Virendra 
Published: January 2023

Abstract
Background and Purpose: Resting-state functional MRI (rs-fMRI) studies in Parkinson’s disease (PD) patients with freezing of gait (FOG) have implicated dysfunctional connectivity over multiple resting-state networks. While these findings provided network-specific insights and information related to the aberrant or altered regional functional connectivity, whether these alterations have any effect on topological reorganization in PD-FOG patients is incompletely understood. Understanding higher-order functional organization, which could be derived from the ‘hub’ and the ‘rich-club’ organization of the functional networks could be crucial to identifying the distinct and unique pattern of the network connectivity associated with PD-FOG.
Methods: In this study, we use rs-fMRI data and graph theoretical approaches to explore the reorganization of resting-state network topology in PD-FOG when compared to those without FOG (PD-nFOG). We also compared the higher-order functional organization derived using the hub and rich-club measures in the functional connectivity networks of these PD-FOG patients to understand whether there is a topological reorganization of these hubs in PD-FOG.
Results: We found that the PD-FOG patients showed a noticeable reorganization of hub regions. Regions that are part of the prefrontal cortex, primary somatosensory, motor, and visuomotor coordination areas showed were some of the regions exhibiting altered hub measures in PD-FOG patients. We also found significantly altered feeder and local connectivity in PD-FOG.
Conclusions: Overall our findings demonstrate a widespread topological reorganization and disrupted higher-order functional network topology in PD-FOG which may further assist in improving our understanding of functional network disturbances associated with PD-FOG.
Improved RNA stability estimation indicatess that transcriptional interference is frequent in diverse bacteria
Authors: Georg Jens , Wanney Walja , Youssar Loubna , Kostova Gergana 
Published: January 2023

Abstract
Bacterial gene expression is regulated and tuned via multiple means. This includes differential operon expression via transcriptional interference, which so far could not be globally investigated in vivo. Using stochastic simulations and experimental data from four different bacteria, we show evidence that a consequent rethinking of the classic rifampicin time-series can allow global monitoring and quantifying of in vivo termination by the collision mechanism of transcriptional interference and by trans-acting sRNAs. We provide evidence that transcriptional interference via the collision of sense and antisense transcription is a frequent and hitherto underestimated mechanism for bacterial gene regulation. Furthermore, we show that differential RNA decay, partial termination and internal transcriptional start sites often do not correlate with given gene annotations. This leads to the existence of transcript segments with different half-lifes within one and the same annotated gene which previously led to error prone half-life estimates. A dynamic-programming based segmentation, together with a case dependent fitting-model selection, significantly improves RNA stability estimation.
OWSum – Algorithmic Odor Prediction and Insight into Structure-Odor-Relationship
Authors: Schicker Doris , Singh Satnam , Freiherr Jessica , Grasskamp Andreas 
Published: January 2023

Abstract
We derived and implemented a linear classification algorithm for the prediction of a molecule’s odor, called Olfactory Weighted Sum (OWSum). Our approach relies solely on structural patterns of the molecules as features for algorithmic treatment. In addition to the prediction of molecular odor, OWSum provides insights into properties of the dataset and allows to understand how algorithmic classifications are reached. OWSum achieved an accuracy of 67.7% on our database containing molecules of six different odors and assigned quantitatively structural patterns to odors. This provides chemists with an intuitive understanding of underlying interactions. To deal with ambiguities of the natural language used to describe odor, we introduced descriptor overlap as a metric for the quantification of semantic overlap between descriptors. Thus, grouping of descriptors and derivation of higher-level descriptors becomes possible. Our approach poses a large leap in our capabilities to understand and predict molecular features.
A study of the RLC, RC, and RL electric circuits associated with incomplete I-functions
Authors: Jangid Kamlesh , Nishant M , Samei Mohammad Esmael , Bhatter Sanjay , Purohit Sunil Dutt 
Published: January 2023

Abstract
The goal of this article is to figure out the electric circuit responses under an impressed voltage E0 f(w) associated with incomplete I-functions and incomplete ī-functions. The analytical solutions for the RLC, RC and RL circuit are derived using the Laplace transform approach.
(2010) Mathematics Subject Classifications: 33B20; 33E20; 26A33.
Using Machine Learning to Develop a Clinical Prediction Model for SSRI-associated bleeding: a feasibility study
Authors: Goyal Jatin , Ng Ding Quan , Zhang Kevin , Chan Alexandre , Lee Joyce , Zheng Kai , Hurley-Kim Keri , Nguyen Lee , He Lu , Nguyen Megan , McBane Sarah , Li Wei , Cadiz Christine Luu 
Published: January 2023

Abstract
Introduction: Adverse drug events (ADEs) are associated with poor outcomes and increased costs but may be prevented with prediction tools. With the National Institute of Health All of Us (AoU) database, we employed machine learning (ML) to predict selective serotonin reuptake inhibitor (SSRI)-associated bleeding.
Methods: The AoU program, beginning in 05/2018, continues to recruit ≥18 years old individuals across the United States. Participants completed surveys and consented to contribute electronic health record (EHR) for research. Using the EHR, we determined participants who were exposed to SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, vortioxetine). Features (n=88) were selected with clinicians’ input and comprised sociodemographic, lifestyle, comorbidities, and medication use information. We identified bleeding events with validated EHR algorithms and applied logistic regression, decision tree, random forest, and extreme gradient boost to predict bleeding during SSRI exposure. We assessed model performance with area under the receiver operating characteristic curve statistic (AUC) and defined clinically significant features as resulting in >0.01 decline in AUC after removal from the model, in three of four ML models.
Results: There were 10,362 participants exposed to SSRIs, with 9.6% experiencing a bleeding event during SSRI exposure. For each SSRI, performance across all four ML models was relatively consistent. AUCs from the best models ranged 0.632–0.698. Clinically significant features included health literacy for escitalopram, and bleeding history and socioeconomic status for all SSRIs.
Conclusions: We demonstrated feasibility of predicting ADEs using ML. Incorporating genomic features and drug interactions with deep learning models may improve ADEprediction.
Reducing hospital readmissions amongst people experiencing homelessness: a mixed-methods evaluation of a multi-disciplinary hospital in-reach programme
Authors: Malden Stephen , Doi Larry , Ng Lauren , Cuthill Fiona 
Published: January 2023

Abstract
Introduction: Homeless people are at increased risk of experiencing ill-health. They are often readmitted to hospital even after discharge, usually for the same or similar reasons for initial hospitalisation. One way of addressing this issue is through hospital in-reach initiatives, which have been established to enhance the treatment and discharge pathways that patients identified as homeless receive after hospital admission. Since 2020, the Hospital In-reach programme has been piloted in two large National Health Service (NHS) hospitals in Edinburgh, United Kingdom (UK). This study describes an evaluation of the programme.
Methods: This evaluation used a mixed method, pre-post design. To assess the effect of the programme on hospital readmission rates from baseline (12 month pre-intervention) and follow-up (12 months post-intervention), aggregate data describing the proportions of homeless individuals admitted to hospital during the evaluation period were analysed using Wilcoxon signed rank test, with level of significance set at p=0.05. Qualitative interviews were conducted with fifteen programme and hospital staff (nurses, general practitioners, homeless link workers) to assess the processes of the programme.
Results: A total of 768 referrals, including readmissions, were made to the in-reach programme during the study period, of which eighty–eight individuals were followed up as part of the study. In comparison to admissions in the previous 12 months, readmissions were significantly reduced at 12 months follow-up by 68.7% (P=0.001) for those who received an in-reach intervention of any kind. Qualitative findings showed that the programme was valued by hospital staff and homeless community workers. Housing services and clinical staff attributed improvements in services to their ability to collaborate more effectively in secondary care settings. This ensured treatment regimens were completed and housing was retained during hospital admission, which facilitated earlier planning for discharge.
Conclusions: A multidisciplinary approach to reducing readmissions in people experiencing homelessness was effective at reducing readmissions over a 12 month period. The programme appears to have enhanced the ability for multiple agencies to work more closely and ensure the right care is provided for those at risk of readmission to hospital among people affected by homelessness.
A Most Peculiar Interferometer
Authors: Korula Aswan 
Published: January 2023

Abstract
In this paper we conduct a simple experiment wherein we create a wave within a circular container and analyse the interference patterns generated by the reflections from the boundary. In doing so we observe constructive interference in positions in space where our current wave theory predicts noise. This result demonstrates that in the particular situation presented here, the velocities of a wave before and after reflection from a solid boundary, are unequal. Analysing these peculiar events, we explore theoretical and observational equivalencies between our water wave experiment and the Michelson-Morley experiment of 1887.
Dissolution Profile Evaluation of Seven Brands of Amoxicillin-Clavulanate Potassium 625 mg Tablets Retailed in Hawassa Town, Sidama Regional State, Ethiopia
Authors: Endashaw Eyob , Tatiparthi Ramanjireddy , Mohammed Tesfaye , Tefera Yesuneh , Teshome Henok , Duguma Markos 
Published: January 2023

Abstract
Back-ground: Poor quality Amoxicillin-clavulanate potassium tablets have been recently discovered in generic drugs related to Augmentin-like medicines containing amoxicillin and clavulanic acid, as well as its derivatives containing falsified active ingredients. One of the most important dosage form characteristics is a detailed API dissolution profile obtained through dissolution testing. The dissolution test is used in the development of both brand-name and generic drugs. Prior to beginning bioequivalence studies, it is critical to compare the dissolution profiles of various pharmaceutical products. As a result, dissolution is a critical quality control parameter for drugs because it has a direct impact on absorption. Objective: Dissolution Profile Evaluation of Seven Brands of Amoxicillin-Clavulanate Potassium Tablets Retailed in Hawassa Town, Sidama Regional State, Ethiopia. Methods: The seven brands of amoxicillin-clavulanate potassium tablets were collected from Hawassa town, Sidama Regional State, Ethiopia. The dissolution study was conducted as per USP40-NF35, and the dissolution profile was compared by One-way ANOVA Dunnett’s test, model independent, and model dependent method. Results: All of the included brand tablets complied with a single-point dissolution study specification. All brand tablets had similar dissolution profiles (p > 0.05), difference factor (f1) < 15%, and dissolution efficiency (\((\le 10\%\)). However, the f2 (similarity factor) value justify that all brand tablets were not within USFDA specification (\(\ge\)50%). The evaluated brands followed the Korsmeyer peppas- followed by Weibull curve approaches. Conclusions: All brand tablets passed the single point USP dissolution specification, and the USFDA therapeutic interchangeability guidelines. The similarity factor (f2), on the other hand, confirmed that none of the tested brand tablets were interchangeable with the innovator product. Therefore, researchers, national medicine regulatory bodies, and the manufacturer should conduct a properly designed dissolution test as proof of an in vitro bioequivalence study supported by in vivo bioavailability data.