bluuebunny/crossref_metadata_2025_split huggingface dataset:
An academic clinical study to assess the efficacy and safety of nandrolone decanoate and alendronate compared with alendronate alone in patients with osteoporosis
Authors: Dave Bharat R , Bali Shivakumar A , Degulmadi Devanand , Krishnan Ajay , Mayi Shivanand , Rai Ravi Ranjan 
Published: August 2023

Abstract

Objective:
The purpose of the study was to evaluate the efficacy and safety of therapy with nandrolone decanoate and alendronate compared with alendronate monotherapy in patients with osteoporosis.

Materials and Methods:
Osteoporotic patients with T scores less than or equal to -2.5 (World Health Organization) either at lumbar vertebrae or hip, fulfilling inclusion criteria were enrolled in the study. Patients were randomized into two groups. Patients in group A were administered injection of Deca Durabolin (nandrolone decanoate) 50-mg intramuscular every 3 weeks for 12 weeks followed by every 4 weeks for the next 36 weeks along with alendronate 70 mg per oral (p.o) every week for 48 weeks. Patients in group B received only alendronate 70 mg (p.o) for 48 weeks. Follow-up was done at 3, 6, and 12 months for clinical evaluation and answering the questionnaire.

Results:
A total of 230 patients with the mean age of 60 years were enrolled in the study. At the end of 1 year, 53 patients were lost to follow‑up, and 177 patients were included in the study analysis. Enrolled patients were randomized to group A (n = 89) and group B (n = 88). Patients in group A had significantly higher improvement in bone mineral density (BMD) of lumbar spine, frailty score, quality-of-life (QOL) score compared with patients in group B. Patients in both groups had improvement in BMD of hip, lean mass, body fat, Oswestry disability index, and visual analog score but it was not statistically significant on the intergroup comparison.

Conclusion:
Our results demonstrate that the addition of nandrolone decanoate to alendronate therapy increases lumbar spine BMD. Improvement in bone quality also translates into an improvement in patient-related outcome measures such as QOL and frailty scores.
Computer navigation-guided transpedicular excision of L4 vertebral body osteoblastoma
Authors: Ramachandran Karthik , Naik Ashish Shankar , Shetty Ajoy Prasad , Rajasekaran Shanmuganathan 
Published: August 2023

Abstract
Osteoblastoma is a benign bone tumor that accounts for 10% of all spinal tumors and mostly arises from the posterior spinal elements. Isolated vertebral body osteoblastoma is relatively rare and generally requires extensive surgery. We report a rare case of L4 vertebral body osteoblastoma, which was managed successfully by computer navigation-guided transpedicular excision. A 22-year-old female presented with progressive lower back pain for the past six months. Radiological investigation revealed a sclerotic lesion involving the anterior cortex with a prominent central nidus in the anterior part of the L4 vertebral body. Based on the lesion size, a diagnosis of benign osteoblastoma (Enneking stage 2) was made, and she underwent computer navigation-assisted intralesional excision of the lesion by the bilateral transpedicular route. Histopathological examination confirmed the diagnosis of osteoblastoma. In the immediate postoperative period, the patient was completely relieved of symptoms, and the final follow-up magnetic resonance imaging showed no evidence of recurrence at the end of seven years. The intraoperative 3D navigation technology allowed a transpedicular minimal access approach to excise an osteoblastoma of the L4 vertebral body while preserving intervertebral stability and decreasing morbidity.
Gangliocytic paraganglioma of the cauda equina: A rare tumor case report with literature review
Authors: Palliyil Nigil Sadanandan , Vellara Jim F , Sailendra Sai , Yesodharan Jyotsna 
Published: August 2023

Abstract
Gangliocytic paragangliomas are rare, benign, encapsulated, and slow-growing tumors arising from the neuro-ectodermal ganglion or spindle cells. We describe the case of a 47-year-old male patient who presented to our department with intractable lower back pain with occasional radiation to the lower limbs over the past two months. His magnetic resonance imaging scan showed an intradural extramedullary lesion at L2–L3 level. He underwent total surgical excision of the tumor with no perioperative complications. The histopathological examination and immunohistochemistry was suggestive of gangliocytic paraganglioma. He had complete resolution of his symptoms following the surgery. In addition to the case presentation, we have also performed a review of the literature.
Prevalence of Anxiety amongst Elderly People Residing in Old-Age Homes: A Cross-Sectional Study from Sub-Himalayan Region, Uttarakhand, India
Authors: Sharma Suresh K. , Malhotra Priyanka , Lata Hem , Sahotra Shayna , Choudhary Rekha 
Published: August 2023

Background:
Changing social structure, urbanization, industrialization and globalization of Indian society have compelled more number of elderly to stay in old age homes for safety, security, independence, companionship and support. It is clearly evident that elderly people are at increasing risk of several psychiatric morbidities, which range between 30 – 64.4% among residents of OAHs in India. However, there is paucity of regional data on clinically significant anxiety among elderly residing in OAHs.

Aims:
To assess the prevalence rate of anxiety and its association with selected socio-demographic characteristics of elderly people residing in selected old age homes (OAHs) of Uttarakhand, India.

Patients and Methods:
This cross-sectional study was conducted on elderly people residing in selected OAHs of Uttarakhand. Total 70 participants were selected from three different old age homes by using proportionate stratified random sampling technique and Geriatric Anxiety Inventory (GAI), a standardized anxiety screening tool was used to assess the anxiety in elderly.

Result:
Data were analyzed using descriptive and inferential statistics and presented using frequency and proportion distribution in cross summary tables. Chi-quire test and 95% confidence interval of proportion was used as inferential statistics. The prevalence rate of clinically significant anxiety was 24% (95%CI= 14.8,36.0%); which was significantly associated with female gender, past low employment status, abuse by family and staying in OAH due to lack of support from children (P<0.05).

Conclusion:
Regular assessment and adequate treatment of anxiety in residents of OAHs is essential for prevention of long-term deleterious consequences on their physical health and quality of life.
The Role of Novel Tiered Reporting System in Serous Fluid Cytology and Risk of Malignancy Assessment: A Retrospective Study in a Tertiary Care Center
Authors: Alashetty Soumya , Sadasivan Balu , Dharmalingam Priya , Rajagopal Nethra , Kavya Lucas , Pai Malathi M. 
Published: August 2023

Background:
Serous effusion cytology (SEC) reporting is important for the management of the cancer patient. The International System for Reporting Serous Fluid Cytology (ISRSFC) provides tiered reporting terminology to standardize practice, looking into the risk of malignancy (MAL) for each category. In this study, we have assessed the utility of the ISRSFC and reported our experience at a tertiary cancer center.

Materials and Methods:
Serous fluid cytology reported from January 2019 to December 2020 was categorized according to ISRSFC diagnostic categories: nondiagnostic (ND), negative for MAL (NFM), atypia of undetermined significance (AUS), suspicious for MAL (SFM), and MAL. The risk of MAL (ROM) and performance parameters were calculated.

Results:
A total of 2150 serous effusions including 1160 pleural, 929 peritoneal, and 61 pericardial effusions from 2071 patients were reported. There were 742 males and 1329 females. The patient’s age ranged from less than 1 yr to 95 years. The volume of the sample ranged from 0.5 ml to 2000 ml. There were 114 ND (5.32%), 1068 NFM (49.67%), 144 AUS (6.69%), 82 SFM (3.81%), and 742 MAL (34.51%) cases. Adenocarcinoma was the most common MAL involving serous fluids (91.50%). The calculated ROM was 15.38% for ND, 24.26% for NFM, 62.96% for AUS, 79.16% for SFM, and 100% for MAL. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were, respectively, 68.04%, 96.96%, 96.35%, 72.07%, and 81.33%.

Conclusion:
ISRSFC provides consistent reporting terminology and the ROM for each category aids in clinical correlation and management.
Heat Induced Processing of Cellblocks with Significant Reduction in Overall Turn Around Time
Authors: Dhende Suhas , Pathuthara Saleem , Prabhudesai Neelam , Shinde Dipak , Karnik Nupur , Deodhar Kedar 
Published: August 2023

Introduction:
Cellblock (CB) with immunohistochemistry (IHC) is practically indispensable in the diagnostic workup of serous effusions; however, CB requires a minimum of 15–20 h for routine histopathological processing. A reduction in processing time can expedite a faster diagnosis.

Aim:
This study was undertaken to evaluate the utility of the heat-induced CB (HICB) technique.

Material and Methods:
Two sets of agar-embedded CBs were processed from 50 effusion samples. CBs were further processed by conventional and rapid methods. Conventional CBs (CCB) were processed in a histoprocessor, whereas rapid CB was processed in a heated water bath with an agitation facility. For HICB processing, dehydration and clearing were performed at 50°C followed by paraffin wax impregnation at 65°C temperature. From both CBs, sections of 5 um thickness were cut and stained with hematoxylin and eosin (H and E). Cell morphology, cost, and time were compared between the two methods. The feasibility of IHC was attempted in a few cases.

Results:
HICB was completed within 4.30 h compared with CCB. Diagnoses on both CBs were concordant in all the cases. Incomplete dehydration was noted in six (12%) cases, but the diagnosis was not compromised. No additional cost was involved in HICB. On IHC, both HICB and CCB exhibited equivalent expression.

Conclusions:
HICB is a rapid, innovative, simple, and cost-effective technique and expedites faster diagnosis. It does not require any advanced equipment.
Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia
Authors: Alzahrani Mohammed A. , Alfahadi Mohammed A. , Alshehri Meshref A. , Alamri Abdulaziz H. , Almahjani Eman A. , Alahmari Aishah M. , Al-Shahrani Abdullah A. , Alshahrani Abdulaziz S. , Almanjahi Ibrahim M. , Alqarni Abdullah M. 
Published: August 2023

Abstract

Background:
Esophageal motility disorders (EMDs) can significantly impact patients’ quality of life. The Chicago Classification (CC) was developed as a robust framework to enable clinicians to better understand and classify the nature of motility disorders. Previous studies have primarily focused on the CC version 3.0 (CCv3.0), and data regarding the correlation between symptoms and CC version 4.0 (CCv4.0) in the Saudi Arabian population are lacking. This study aimed to assess the correlation between symptoms and CCv3.0 and CCv4.0 using high-resolution esophageal manometry (HRM) in Saudi Arabia, to evaluate the diagnostic performance of both classifications.

Methods:
A total of 182 patients presenting with esophageal symptoms were included in this study. HRM was performed to assess esophageal motility, and patients’ reported symptoms were recorded. The association between HRM findings and symptomatic variables was analyzed using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).

Results:
Variability was observed in the diagnostic performance of symptomatic variables for major EMDs. CCv4.0 demonstrated a higher sensitivity for dysphagia than CCv3.0; however, it exhibited lower sensitivity to atypical gastroesophageal reflux disease (GERD) symptoms. Noncardiac chest pain (NCCP) exhibited the highest specificity and PPV, whereas typical GERD symptoms showed lower specificity.

Conclusion:
CCv4.0 demonstrated potential improvements in sensitivity for dysphagia, but lower sensitivity for atypical GERD symptoms, compared with CCv3.0. These insights provide guidance for clinicians in Saudi Arabia and contribute to understanding the diagnostic performance of CCv3.0 and CCv4.0.
HUBUNGAN PENGGUNAAN GADGET TERHADAP KUALITAS TIDUR MAHASISWA DI ASRAMA UNIVERSITAS ADVENT INDONESIA
Authors: Parulian David , Soputri Nilawati 
Published: August 2023

Gadget adalah benda kecil yang banyak membantu mahasiswa dalam belajar dan menyelesaikan masalah perkuliahan. Penggunaan gadget yang berlebihan seperti penggunaan dengan durasi dan aktifitas yang tinggi akan menimbulkan efek yang tidak baik terhadap mahasiswa. Salah satu masalah penggunaan gadget yang berlebihan adalah mengganggu kualitas tidur. Tujuan dari penelitian ini untuk mengetahui hubungan penggunaan gadget dengan kualitas tidur mahasiswa di asrama Universitas Advent Indonesia. Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian deskriptif korelasi. Populasi dalam penelitian ini adalah Mahasiswa semester padat pada tahun ajaran 2022/2023 yang tinggal diasrama dengan fasilitas internet 24 jam penuh. Populasi berjumlah 132 Mahasiawa aktif Universitas Advent Indonesia. Teknik sampling yang digunakan adalah sampling jenuh karena seluruh mahasiswa tersebut ikut berpartisipasi dalam penelitian ini. Instrument yang digunakan untuk mengumpulkan data penggunaan gadget adalah kuesioner smartphone addiction pengumumpulan data kualitas tidur adalah kuesioner kuliatas tidur PSQI. Seluruh data dikumpulkan dengan google form. Data diproses dengan menggunakan SPSS 29. Hasil penelitian menunjukan penggunaan gadget dengan waktu rentang kurang dari <1 jam sebanyak 3%, 1-6 jam berjumlah 31%, 7-12 jam sebesar 48%, dan >12 jam sebanyak 18%. Kualitas tidur respondent dalam kategori baik sebanyak 14% dan buruk 86%. Hasil uji Chi-square menunjukan ada hubungan antara penggunaan gadget dengan kualitas tidur mahasiswa diasrama Universitas Advent Indonesia, dengan nilai p = 0.014 (pvalue < 0,05).
Analisis Strategi Bauran Pemasaran Pada Usaha Kripik Talas Fitri Di Rantepao Kabupaten Toraja Utara
Authors: Yarden Yarden , Tapparan Samuel Randy 
Published: August 2023

This study aims to determine the Marketing Mix Strategy in the Taro Fitri Chips Business in Rantepao, Toraja Regency which includes product, price, place, and promotion. The type of research used in this research is descriptive research method. Descriptive research method is research that produces descriptive data in the form of written or spoken words from people or observable behavior. Techniques and procedures for data collection were conducted by interview, observation and documentation.
The results obtained in this study: 1) The product strategy at Kripik Talas Fitri includes product diversity, product quality, product packaging, and service. 2) Pricing strategy includes price lists and discounting prices for customers. 3) Place strategy includes location. 4) Promotional strategies include advertising, direct sales, through social media, and distribution of name stickers in restaurants and cafes where products are stored.
Keywords: Marketing Mix Strategy, Product, Price, Place, And Promotion
Abstrak

Penelitian ini bertujuan untuk mengetahui Strategi Bauran Pemasaran Pada Usaha Kripik Talas Fitri Di Rantepao Kabupaten Toraja yang meliputi produk, harga, tempat, dan promosi. Jenis penelitian yang digunakan dalam penelitian ini adalah metode penelitian deskriptif. Metode penelitan deskriptif adalah penelitian yang menghasilkan data deskriptif berupa kata-kata tertulis atau lisan dari orang-arang atau perilaku yang dapat diamati. Teknik dan prosedur pengumpulan data dilakukan dengan wawancara, observasi dan dokumentasi,.
Hasil yang diperoleh dalam penelitian ini : 1 ) Strategi produk yang ada di Kripik Talas Fitri meliputi keragaman produk, kualitas produk, kemasan produk, dan pelayanan. 2) Strategi harga meliputi daftar harga dan pemberian potongan harga bagi pelanggan. 3) Strategi tempat meliputi lokasi. 4) Strategi promosi meliputi periklanan, penjualan langsung, melalui media sosial, dan pembagian stiker nama di ruamah amakan dan cafe-cafe tempat penitipan produk.

Kata Kunci: Strategi Bauran pemasaran, Produk, Harga, Tempat, Dan Promosi
Pengaruh Motivasi Kerja terhadap Kinerja Karyawan (Study pada PT. Bank BNI Cabang Kota Malang)
Authors: Ismunawan Ismunawan , Saputro Amin Catur 
Published: August 2023

The purpose of the study was to determine whether or not there is an influence related to work motivation on the performance of employees at PT. Bank BNI Malang City Branch. So in accordance with these objectives, this research includes a type of quantitative research that is causal or causal, and is also included in descriptive research (Explanatory Research). Employee Performance (Study at PT.Bank BNI Malang City Branch)", it can be concluded as follows: Related to work motivation, it is known that the responses of respondents agreed and strongly agreed with the statements that had been submitted on the research questionnaire. So from the results of these studies, it can be concluded that work motivation on employee performance at PT. Bank BNI Malang City Branch is said to be good. This is evident from the work motivation of employees at PT. Bank BNI Malang City Branch has a significant effect on Employee Performance of PT. Bank BNI Malang City Branch. Keywords: Motivation, Job Performance, HRM
Pengaruh Label Halal dan Harga terhadap Keputusan Pembelian Konsumen Pada Produk Mie Samyang Kecamatan Prigen
Authors: Alfiah Alfiah , Muflikha Nur Rismatul 
Published: August 2023

ABSTACTThis study aims to determine the effect of halal labels and prices on purchasing decisions for Samyang Noodle products on users of Samyang Noodle products in Prigen District partially and simultaneously. The population in this study were consumers of Samyang Noodle products in Prigen District. The sampling technique used was non-probability sampling technique because the number of the population is unknown, with purposive sampling as a sampling technique based on certain criteria. The sample in this study were 60 respondents. The method used in this research is a quantitative research approach. This study uses multiple linear regression analysis with data collection using a questionnaire with a Likert scale. The results showed that partially halal label and price had a positive and significant effect on purchasing decisions. Simultaneously, the halal label variable and the price have a positive and significant effect on consumer purchasing decisions for Samyang Noodle products in Prigen District. Keywords : Halal Label, Price and Purchase DecisionABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh label halal dan harga terhadap keputusan pembelian produk Mie Samyang pada pengguna produk Mie Samyang di Kecamatan Prigen secara parsial dan simultan. Populasi dalam penelitian ini adalah konsumen produk Mie Samyang di Kecamatan Prigen. Teknik pengambilan sampel menggunakan Teknik non-probability sampling karena populasi tidak diketahui jumlah anggotanya, dengan purposive sampling sebagai teknik penentuan sampel yang berdasarkan kriteria tertentu. Sampel pada penelitian ini sebanyak 60 responden. Metode yang digunakan pada penelitian ini adalah metode pendekatan penelitian kuantitatif. Penelitian ini menggunakan analisis regresi linier berganda dengan pengumpulan data menggunaka kuesioner dengan skala likert. Hasil penelitian menunjukkan bahwa secara parsial label halal dan harga berpengaruh positif dan signifikan terhadap keputusan pembelian. Secara simultan variabel label halal dan harga berpengaruh positif dan signifikan terhadap keputusan pembelian konsumen produk Mie Samyang di Kecamatan Prigen.Kata Kunci : Label Halal, Harga, dan Keputusan Pembelian
Analisis Pengaruh Kecukupan Modal (CAR) dan Likuiditas (LDR) terhadap Kinerja Keuangan (ROA) Keuangan Bank Swasta Nasional Tahun 2014-2018 (Studi pada Bei Bank Swasta Nasional)
Authors: Ningsih Sri Dwi , Ilhami Sofiya 
Published: August 2023

AbstractThis study aims to determine the effects of Capital Adequacy Ratio (CAR) and Loan to Deposit Ratio (LDRon the Profitability of Rural Banks at National Private sector. The study uses a method with Purposive Sampling. The samples involved were as many as 30 data sources using the observation collection data technique. The analytical tool used is SPSS 25. This data is analyzed by Descriptive Statistics, Classical Assumption Test, Multiple Linear Regression, T Test, and f Test. The results of the study prove that CAR and LDR have a simultaneous influence on ROA at Bank NationalPrivate Sector. Partially, CAR has a positive and significant effect on ROA, LDR has a negative and significant effect on ROA . Keywords - Capital Adequacy Ratio (CAR), Loan to Ratio (LDR), and Return On Assets (ROA). Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh Capital Adequacy Ratio (CAR) and Loan to Deposit Ratio (LDR) Tehadap Profitabilitas Bank Swasta Nasional. Penelitian ini termasuk jenis penelitian kuantitatif. Teknik sampel yang digunakan adalah Purposive Sampling. Sampel yang digunakan sebanyak 30 data observasi. Alat analisis yang digunakan adalah SPSS 25. Data ini dianalisis dengan Deskriptif Statistik, Uji Asumsi Klasik, Regresi Linear Berganda, Uji t, dan Uji f. Hasil penelitian ini membuktikan bahwa CAR dan LDR berpengaruh secara simultan terhadap ROA pada Bank Swasta Nasional. Secara parsial CAR berpengaruh positif dan signifikan terhadap ROA, LDR berpengaruh negatif dan signifikan terhadap ROA. Kata Kunci - Capital Adequacy Ratio (CAR), Loan Deposit to Ratio (LDR), dan Return On Asset(ROA).
The Relevance of the International Criminal Court and Its Possible Deterrent Effects of International Crimes
Authors: Adamu Awa 
Published: August 2023

Purpose: The ICC was established for the primary purpose of ensuring that the most serious crimes of concern to the international community as a whole do not go unpunished and to contribute to the prevention of such crimes. Thus, this paper seeks to determine the possible deterrent effects of international crimes by the ICC through its investigations, prosecutions, sanctions and other activities.
Methodology: The study adopted the doctrinal research method. Both primary and secondary sources like Statute, Case Law, textbooks, journals and internet are used.
Finding: Finding reveals that the Court has not been effective in deterring and preventing international criminality due to lack of cooperation from States and lack of universal jurisdiction.
Recommendation: In order for the Court to effectively deter the commission of international crimes, there is need to alleviate the factors hindering the proper discharge of the Court’s functions like lack of cooperation from states, a standing police force and universal jurisdiction.