bluuebunny/crossref_metadata_2025_split huggingface dataset:
No impact of repeated digital advisory service to Haitian peanut producers
Authors: Schulz Dario , Börner Jan 
Published: September 2023

Abstract
Digital farm advisory services can be a cost-effective way to provide relevant information to smallholders in developing countries. Information provision has been shown to generate positive impacts on agricultural practices and farmers’ income across various settings. We conducted a pre-registered randomized control trial among peanut farmers in Haiti to evaluate the impact of short text messages. We administered two waves of digital information provision and follow-up surveys. Results suggest no measurable impact of digital information delivery on agricultural knowledge, practice adoption, or productivity. We discuss internal and external validity of these findings and derive recommendations for future interventions.
A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment
Authors: Ogese Monday O , Lister Adam , Farrell Liam , Gardner Joshua , Kafu Laila , Ali Serat-E , Gibson Andrew , Hillegas Aimee , Meng Xiaoli , Pirmohamed Munir , Williams Geoffrey S , Sakatis Melanie Z , Naisbitt Dean J 
Published: September 2023

Abstract
In vitro preclinical drug-induced liver injury (DILI) risk assessment relies largely on the use of hepatocytes to measure drug-specific changes in cell function or viability. Unfortunately, this does not provide indications toward the immunogenicity of drugs and/or the likelihood of idiosyncratic reactions in the clinic. This is because the molecular initiating event in immune DILI is an interaction of the drug-derived antigen with MHC proteins and the T-cell receptor. This study utilized immune cells from drug-naïve donors, recently established immune cell coculture systems and blinded compounds with and without DILI liabilities to determine whether these new methods offer an improvement over established assessment methods for the prediction of immune-mediated DILI. Ten blinded test compounds (6 with known DILI liabilities; 4 with lower DILI liabilities) and 5 training compounds, with known T-cell-mediated immune reactions in patients, were investigated. Naïve T-cells were activated with 4/5 of the training compounds (nitroso sulfamethoxazole, vancomycin, Bandrowski’s base, and carbamazepine) and clones derived from the priming assays were activated with drug in a dose-dependent manner. The test compounds with DILI liabilities did not stimulate T-cell proliferative responses during dendritic cell-T-cell coculture; however, CD4+ clones displaying reactivity were detected toward 2 compounds (ciprofloxacin and erythromycin) with known liabilities. Drug-responsive T-cells were not detected with the compounds with lower DILI liabilities. This study provides compelling evidence that assessment of intrinsic drug immunogenicity, although complex, can provide valuable information regarding immune liabilities of some compounds prior to clinical studies or when immune reactions are observed in patients.
Corporate tax reform in the European Union: are the stars finally aligned?
Authors: HJI Panayi Christiana 
Published: September 2023

Abstract
Are the stars finally aligned as far as corporate tax reform in the European Union (EU) is concerned? Tax reform in the EU has always been a contentious issue, as taxation was always considered one of the last bastions of national sovereignty. This article examines whether this is still the case or whether, in light of recent initiatives and proposals in this area, conditions are now ripe for comprehensive reform. The article begins by reviewing the historical trajectory of EU corporate tax law. It is shown that whilst early harmonization proposals were very ambitious, the overall constitutional set-up and the fiscal veto were not conducive to comprehensive reform. What followed these early initiatives was an era of pragmatism and slow progress, which, nevertheless, laid the foundations for important developments. Apart from the ad hoc legislative tax instruments that were agreed upon in the last 30 years to further the internal market and remove obstacles to cross-border movement, this article focused on the Commission’s ongoing work on a common tax base and consolidation, as well as other recent legislative initiatives such as the now enacted Directive on a Minimum Effective Tax Rate and the Unshell proposal. In light of these crucial developments, with all their strengths and weaknesses, it is argued that what was once considered as far too ambitious a proposal indicative of a federal Europe, now has high chances of materializing in the context of the BEFIT initiative (Business in Europe: Framework for Income Taxation). This is to be welcomed, as it is the next organic step to take in the process of EU integration. Whilst the stars may not yet be fully aligned, it is argued that what is needed at this point in time, is a change of mindset and a realization that Member States’ tax sovereignty has long been eroded.
Phylogenetic history of golden moles and tenrecs (Mammalia: Afrotheria)
Authors: Bronner Gary N , Mynhardt Samantha , Bennett Nigel C , Cohen Lientjie , Crumpton Nick , Hofreiter Michael , Arnold Patrick , Asher Robert J 
Published: September 2023

Abstract
We conducted a phylogenetic analysis of genetic and anatomical data focusing on golden moles (Chrysochloridae) and tenrecs (Tenrecidae). Our results support the now well-resolved topology for extant tenrecids, in addition to the paraphyly of ‘Chrysochlorinae’ and the genera Chrysochloris and Chlorotalpa as traditionally used. Carpitalpa arendsi is the sister taxon to Neamblysomus; together, they compose the sister clade of Amblysomus. Unexpectedly, Calcochloris obtusirostris is the sister taxon of Chrysospalax. The oldest divergence within crown Chrysochloridae is likely to be the node separating Eremitalpa–Huetia or Eremitalpa alone from the remaining species. A Chrysochloris–Cryptochloris root appears most frequently under equally weighted parsimony or with few or no sampled tenrecids, suggesting that it is artefactual. The tropical genus Huetia is among the most widely distributed and anatomically polymorphic in our sample. Eremitalpa and Huetia have a relatively unspecialized hyoid apparatus and short angular process of the dentary. These elements in Huetia show a particular resemblance to those of the Namibian fossil Namachloris, which we reconstruct as a stem chrysochlorid. Crown chrysochlorids are geologically younger than crown tenrecids and probably diversified in the Miocene around the same time as the tenrecid genus Microgale. Fossils of both groups from Eocliff in Namibia are probably late Eocene to early Miocene in age.
Quantifying Risk Factors for Slipped Capital Femoral Epiphysis and Postslip Osteonecrosis
Authors: Zusman Natalie L. , Goldstein Rachel Y. , Yoo Jung U. 
Published: September 2023

Background:
Slipped capital femoral epiphysis (SCFE) is a disorder of the proximal femoral physis occurring in late childhood and adolescence. Previously postulated risk factors include obesity and endocrinopathies. The purpose of this investigation was to identify risk factors for developing SCFE, as well as postslip osteonecrosis (ON), among the United States pediatric population.

Methods:
A national database investigation was performed using PearlDiver Technologies, Inc., queried for SCFE and ON using International Classification of Disease codes (2010 to 2020). Regression analyses to determine the risk of developing a SCFE, and ON after a patient has already been diagnosed with a SCFE (“postslip”). Propensity matching between SCFE and control groups generated a pseudo-randomization model to compare the relative risk.

Results:
There were 11,465 patients with SCFE available in the database, matched with 134,680 controls. After matching, vitamin D deficiency, obesity, hypothyroidism, and growth hormone use were risk factors for developing SCFE [relative risk ranges from 1.42 (95% CI: 1.21-1.39, vitamin D deficiency) to 3.45 (95% CI: 3.33-3.57, obesity)]. ON risk factors were vitamin D deficiency [1.65 (1.26-2.14)] and hypothyroidism [1.49 (1.10-2.07)].

Conclusions:
This United States national database study quantified risk factors of developing an SCFE and postslip ON. Obesity is the most significant risk factor for the development of a slip, but not ON. Growth hormone use, hypothyroidism, and vitamin D deficiency are also risk factors for SCFE development, whereas only the latter two were associated with ON. These findings demonstrate the public health implications of obesity and comorbid conditions in pediatric hip pathology.

Level of Evidence:
Level III.
Internet-based Digital Simulation for Cleft Surgery Education: A 10-year Assessment of Demographics, Usage, and Future Directions
Authors: Chaya Bachar F. , Laspro Matteo , Verzella Alexandra N. , Oliker Aaron , Arnold Anne , Alcon Andre , Flores Roberto L. 
Published: September 2023

Background:
In October 2012, an open-access, multimedia digital cleft simulator was released. Its purpose was to address global disparities in cleft surgery education, providing an easily accessible surgical atlas for trainees globally. The simulator platform includes a three-dimensional surgical simulation of cleft care procedures, intraoperative videos, and voiceover. This report aims to assess the simulator's demographics and usage in its tenth year since inception. Finally, we also aim to understand the traction of virtual reality in cleft surgical education.

Methods:
Usage data of the simulator over 10 years were retrospectively collected and analyzed. Data parameters included the number of users, sessions, countries reached, and content access. An electronic survey was emailed to registered users to assess the benefits of the simulator.

Results:
The total number of new and active simulator users reached 7687 and 12,042. The simulator was accessed an average of 172.9.0 ± 197.5 times per month. Low- to middle-income regions accounted for 43% of these sessions. The mean session duration was 11.4 ± 6.3 minutes, yielding a total screen time of 3022 hours. A total of 331 individuals responded to the survey, of whom 80.8% found the simulator to be very useful or extremely useful. Of those involved in education, 45.0% implemented the simulator as a teaching tool.

Conclusions:
Global utilization of the simulator has been sustained after 10 years from inception with an increased presence in low- to middle-income nations. Future similar surgical simulators may provide sustainable training platforms to surgeons in low- and high-resource areas.
Back to Basics
Authors: Al-Tariq Kabir Quazi 
Published: September 2023

ABSTRACT
Lentigo maligna (LM) is a melanocytic neoplasm that occurs on chronically sun-exposed skin commonly affecting middle-aged and elderly patients, which can progress to LM melanoma if left untreated or misdiagnosed. LM can be confused with other dermatologic conditions such as pigmented actinic keratosis, solar lentigo, and seborrheic keratosis. Therefore, clinicians should know the various clinical features that can distinguish LM from other differential diagnoses. Although multiple treatment modalities exist for LM, surgical excision remains the gold standard for the treatment of LM and results in an excellent prognosis for treated patients. This article discusses the pathogenesis, diagnosis, and treatment of LM so that dermatology nurses are better prepared to care for patients with LM.
Mucous Membrane Pemphigoid
Authors: DiRuggiero Margaret , DiRuggiero Douglas , Young Peter A. , Page Robert , Clark Jane , Hall Emily , Chung John 
Published: September 2023

ABSTRACT:
Separate case reports have described linear Immunoglobulin A (IgA) bullous dermatosis with histology mimicking oral lichen planus and ocular involvement with resultant blindness. Here, we describe a patient with known ocular cicatrizing disease but was unaware of an evolving rash of the oral mucosa. Subsequent biopsies were procured to investigate whether linear IgA dermatosis exhibited lichenoid changes mimicking lichen planus or if the patient had concomitant linear IgA dermatosis and lichen planus. Conclusively, both entities may cause scarring, and for the purpose of avoiding diagnostic confusion, we have categorically appropriated both under mucous membrane pemphigoid.
Use of Platelet-Rich Plasma in the Management of Alopecia Areata
Authors: Cook Madison K. , De Souza Brianna R. , Gosch Marianne E. , Yu Dongfang , Pichardo Rita O. 
Published: September 2023

Introduction
Classic treatment options for patients with alopecia areata (AA) include intralesional and topical steroids as well as oral immunotherapy. Although these options can be effective for some patients, topical therapies are often inconvenient, and there can be many side effects with oral medications. Platelet-rich plasma (PRP) is an autologous preparation of concentrated platelets that is an emerging therapy for various conditions such as chronic nonhealing wounds, muscle injuries, and, more recently, hair loss.

Case Presentation
A 71-year-old woman with diffuse hair loss diagnosed previously as AA presented to our clinic after nonresponse to topical steroids and adverse events with topical minoxidil use. At our clinic, the patient underwent three treatments with PRP injections. Total hair regrowth without relapse was noted 6 months after treatment cessation.

Discussion/Conclusion
Our case illustrates a situation in which PRP served as an effective, rapid, and safe treatment option in a patient with AA who was unresponsive to previous standard therapies and feared side effects of oral medications.
Hats Off for Full-term Healthy Newborns
Authors: Lazzeri Jessica , Giordano Nicholas A. , Christ Lori , Polomano Rosemary C. , Stringer Marilyn 
Published: September 2023

Background:
Hyperthermia is a known risk for sudden unexpected infant death. The practice of hat placement at birth to prevent transient hypothermia may not be necessary and sets an early standard for clothing infants that may lead to hyperthermia postnatally.

Objective:
To examine the elimination of hats on thermoregulation (eg, hypothermia, <97.6°F) in full-term newborns with no abnormalities within 24 hours of birth.

Methods:
In 2018, an institution guideline discontinued the use of hats at birth. Subsequently, newborn body temperatures were respectively extracted from electronic health records and data were compared from 482 infants (>38 weeks' gestation and newborn birth weight >2500 g) prior to (n = 257) and following (n = 225) the practice change. Body temperatures prior to and after the practice change to eliminate hats use were compared.

Results:
No statistically significant difference was observed: (1) in the proportion of infants experiencing hypothermia with or without hat use, respectively, 23.7% compared with 31.1% (P = .09) and (2) in the odds of an infant experiencing hypothermia when adjusting for relevant covariates (odds ratio = 1.44; 95% confidence interval 0.89-2.32); P = .14).

Conclusions:
Our findings demonstrate that the use of hats on infants at birth had no measurable impact on newborn thermoregulation.
Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: A bibliometric analysis from 2012 to 2022
Authors: Gao Xiang , Huang Xin , Wang Yehui , Sun Sheng , Chen Tao , Gao Yongxiang , Zhang Xiaodan 
Published: September 2023

Background:
Recent studies have shown substantial progress in understanding the association between epigenetics and autoimmune diseases. However, there is a lack of comprehensive bibliometric analysis in this research area. This article aims to present the current status and hot topics of epigenetic research in autoimmune diseases (ADs) from a bibliometric perspective, as well as explore the frontier hotspots and trends in epigenetic studies related to ADs.

Methods:
This study collected 1870 epigenetic records related to autoimmune diseases from the web of science core collection database, spanning from 2012 to 2022. Analysis of regions, institutions, journals, authors, and keywords was conducted using CiteSpace, VOSviewer, and the R package “bibliometrix” to predict the latest trends in epigenetic research relevant to autoimmune diseases.

Results:
The number of epigenetic publications related to autoimmune diseases has been increasing annually. The United States has played a major role in this field, contributing over 45.9% of publications and leading in terms of publication volume and citation counts. Central South University emerged as the most active institution, contributing the highest number of publications. Frontiers in Immunology is the most popular journal in this field, publishing the most articles, while the Journal of Autoimmunity is the most co-cited journal. Lu QJ is the most prolific author, and Zhao M is the most frequently co-cited author. “Immunology” serves as a broad representative of epigenetic research in ADs. Hot topics in the field of epigenetic modifications associated with autoimmune diseases include “regulatory T cells (Treg),” “rheumatoid arthritis,” “epigenetic regulation,” “cAMPresponsive element modulator alpha,” “cell-specific enhancer,” “genetic susceptibility,” and “systemic lupus erythematosus.” Furthermore, the study discusses the frontiers and existing issues of epigenetic modifications in the development of autoimmune diseases.

Conclusions:
This study provides a comprehensive overview of the knowledge structure and developmental trends in epigenetic research related to autoimmune diseases over the past 11 years.
Associations between non-coding RNAs genetic polymorphisms with ovarian cancer risk: A systematic review and meta-analysis update with trial sequential analysis
Authors: Liu Huaying , Sun Lili , Liu Xiaoping , Wang Ruichai , Luo Qinqin 
Published: September 2023

Background:
This systemic review and meta-analysis seeks to systematically analyze and summarize the association between non-coding RNA polymorphisms and ovarian cancer risk.

Methods:
We searched PubMed, Web of Science and CNKI for available articles on non-coding RNA polymorphisms in patients with ovarian cancer from inception to March 1, 2023. The quality of each study included in the meta-analysis was rated according to the Newcastle–Ottawa Scale.
Odds ratios (ORs) with their 95% confidence intervals (95% CI) were used to assess associations. Chi-square Q-test combined with inconsistency index (I2) was used to test for heterogeneity among studies. Lastly, trial sequential analysis (TSA) software was used to verify the reliability of meta-analysis results, and in-silico miRNA expression were also performed. The meta-analysis was registered with PROSPERO (No. CRD42023422091).

Results:
A total of 17 case-control studies with 18 SNPs were selected, including 2 studies with H19 rs2107425 and HOTAIR rs4759314, and 5 studies with miR-146a rs2910164 and miR-196a rs11614913. Significant associations were found between H19 rs2107425, miR-146a rs2910164, and miR-196a rs11614913 and ovarian cancer risk. Three genetic models of H19 rs2107425 (CT vs TT (heterozygote model): OR = 1.36, 95% CI = 1.22–1.52, P < .00001; CC + CT vs TT (dominant model): OR = 1.12, 95% CI = 1.02–1.24, P = .02; and CC vs CT + TT (recessive model): OR = 1.23, 95% CI = 1.16–1.31, P < .00001), 2 genetic models of miR-146a rs2910164 (allele model: OR = 1.75, 95% CI = 1.05–2.91, P = .03; and heterozygote model: OR = 0.33, 95% CI = 0.11–0.98, P = .05), 3 genetic models of miR-196a rs11614913 (allele model: OR = 0.70, 95% CI = 0.59–0.82, P < .0001; dominant model: OR = 1.62, 95% CI = 1.18–2.24, P = .0001; and recessive model: OR = 0.70, 95% CI = 0.57–0.87, P = .03) were statistically linked to ovarian cancer risk. Subgroup analysis for miR-146a rs2910164 was performed according to ethnicity. No association was found in any genetic model. The outcomes of TSA also validated the findings of this meta-analysis.

Conclusion:
This study summarizes that H19 rs2107425, miR-146a rs2910164, and miR-196a rs11614913 polymorphisms are significantly linked with the risk of ovarian cancer, and moreover, large-scale and well-designed studies are needed to validate our result.
Efficacy and safety of diacerein and celecoxib combination therapy for knee osteoarthritis: A double-blind, randomized, placebo-controlled prospective study
Authors: Youn Sangah , Choi Ji Hye , Kim Chulmin , Kim Seon-Mee , Choi Whan Seok 
Published: September 2023

Background:
Osteoarthritis is a degenerative disease with a growing burden in South Korea. Corresponding drugs are commonly used for pain relief and joint function improvement. Specifically, symptomatic slow-acting drugs for osteoarthritis are frequently used, with diacerein being the most common symptomatic slow-acting drugs for osteoarthritis in South Korea. In this study, we evaluated the efficacy and safety of diacerein and celecoxib combination therapy in patients with osteoarthritis.

Methods:
A total of 71 subjects were randomly assigned to group 1 (diacerein and celecoxib), 2 (diacerein and placebo), or 3 (celecoxib and placebo). The primary outcome measure was the change in the visual analog scale (VAS) score 12 weeks after treatment.

Results:
The combination therapy group exhibited a significant decrease in the VAS score, alongside the other control monotherapy groups. Although there was no significant difference between the groups, the combination therapy group exhibited a greater decrease in the absolute value of the VAS score than the other groups. Four weeks after treatment, the combination therapy group showed significantly higher improvement in the stiffness and physical function categories of the Western Ontario and McMaster Universities Osteoarthritis Index than the other groups. Additionally, no serious adverse events occurred following combination therapy, with most adverse events being mild and resolving without specific treatment.

Conclusions:
Diacerein and celecoxib combination therapy is as safe and effective as corresponding monotherapies. A relatively early improvement in stiffness and physical function following treatment with this combination therapy indicates that physicians should consider this for the early-stage treatment of patients with symptomatic osteoarthritis.