bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Estimation Value of 99mTc-MAA in Comparison with 90Y-PET/MR-based Dosimetry in Selective Internal Radiation Therapy (SIRT) for Liver Malignancies
Authors: Yeyin Nami , Abuqbeitah Mohammad , Namazova Aysel , Demir Mustafa 
Published: January 2025

Background:
Neurodegenerative diseases are a group of disorders characterized by progressive
neuronal degeneration and death, of which Alzheimer's disease and Parkinson's disease
are the most common. These diseases are closely associated with increased expression of monoamine
oxidase B (MAO-B), an important enzyme that regulates neurotransmitter concentration, and
its overactivity leads to oxidative stress and neurotoxicity, accelerating the progression of neurodegenerative
diseases. Therefore, the development of effective MAO-B inhibitors is important for
the treatment of neurodegenerative diseases.

Objective:
This study aims to improve the prediction of the efficacy of novel 6-hydroxybenzothiazole-
2-carboxamide compounds in inhibiting MAO-B by improving the quantitative constitutive
effect relationship (QSAR) modeling and to provide a theoretical basis for the discovery of
novel neuroprotective drugs.

Methods:
The study first optimized the structures of 36 compounds using the heuristic method
(HM) in CODESSA software to construct linear QSAR models. Subsequently, key descriptors were
screened by using the gene expression programming (GEP) technique to generate nonlinear QSAR
models and validate them.

Results:
The R², F-value, and R²cv of the linear model were 0.5724, 10.3752, and 0.4557, respectively,
whereas the nonlinear model constructed by the GEP algorithm showed higher prediction
accuracies by achieving R² values of 0.89 and 0.82, and mean squared errors (MSE) of 0.0799 and
0.1215 for the training and test sets, respectively. In addition, molecular docking experiments confirmed
that the novel compound 31 was tightly bound to the MAO-B active site with significant
inhibitory activity.

Conclusion:
In this study, we successfully improved the prediction ability of the efficacy of novel
6-hydroxybenzothiazole-2-carboxamide compounds to inhibit MAO-B by improving the QSAR
model. This not only provides new drug candidates for the treatment of neurodegenerative diseases,
but also provides important theoretical guidance for subsequent drug design and development,
which can help accelerate the process of new drug discovery and reduce the disease burden of patients.
Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based
Second-Generation Artificial Intelligence System
Authors: Rinott Ehud , Sigawi Tal , Hurvitz Noa , Elchatib Narmin , Rinsky-Halivni Lilah , Ilan Yaron 
Published: January 2025

Objective:
Regular physical activity (PA) promotes mental and physical health. Nevertheless,
inactivity is a worldwide pandemic, and methods to augment exercise benefits are required.
The constrained disorder principle (CDP) characterizes biological systems based on their
inherent variability. Therefore, we aimed to investigate the association between intra-individual
variability in PA and disability among non-athlete adults.

Methods:
In this retrospective analysis of the longitudinal SHARE survey, we included non-disabled
adults aged >50 with at least six visits over 14 years. Self-reported PA frequency was documented
bi- to triennially. Low PA intensity was defined as vigorous PA frequency less than once a
week. Stable PA was described as an unchanged PA intensity in all consecutive middle observations.
The primary outcome was defined as a physical limitation in everyday activities at the end
of the survey. Secondary outcomes were cognitive functions, including short-term memory, longterm
memory, and verbal fluency.

Results:
The study included 2,049 non-disabled adults with a mean age of 53 and 49.1% women.
In the initially high PA intensity group, variability in PA was associated with increased physical
disability prevalence (23.3% vs. 33.2%, stablevs.unstable PA; P<0.01; adjusted P<0.01). In the initially
low PA intensity group, variability was associated with a reduced physical disability (45.6%
vs. 33.3%, stablevs.unstable PA; P=0.02; adjusted P=0.03). There were no statistically significant
differences in cognitive parameters between the groups. Among individuals with the same low PA
intensity at the beginning and end of follow-up, variability was associated with reduced physical
disability (56.9% vs. 36.5%, stablevs.unstable PA; P=0.02; adjusted P=0.04) and improved short-
-term memory (score change: -0.28 vs. +0.29, stablevs.unstable PA; P=0.05).

Conclusion:
Incorporating variability into PA regimens of inactive adults may enhance their physical
and cognitive benefits.
Metric Dimension of Banded-Turán Graph
Authors: Huda Muhammad Nurul , Hartono Hartono 
Published: January 2025

Given a graph G=(V(G),E(G)). Let S={s1,...,sk} be an ordered subset of V(G). Consider a vertex x, a coordinate of x with respect to S is represented as r(x|S)=(d(x,s1),...,d(x,sk)) where d(x,si) equals the number of edges in the shortest path between x and si for i=1,...,k. The minimum value of k such that for every x has distinct coordinate is called metric dimension of G. Turán graph T(n,r), n=r=2 is a subgraph of complete r-partite graph on n vertices having property that the difference of cardinality of any two distinct classes is at most one. In this paper, we build a new graph namely a banded-Turán graph, BT(n,r,m), as a graph built by a Turán graph T(n,r) and r uniform path graphs Pm in which every vertex of each class of T(n,r) connected to an initial vertex of corresponding path graph Pm. Intuitively, this graph illustrates as if a Turán graph is banded by r uniform ropes. We determine some basic graph properties including independence number, chromatic number, and diameter of banded-Turán. The main result in this paper is we obtain that the metric dimension of banded-Turán turns out that it depends on the number of its classes. If it has two classes then the metric dimension is equal to n-1 and if it has more than two classes then the metric dimension is equal to the metric dimension of Turán graph included in it.
Parental Technoference and Child Problematic Media Use: Meta-Analysis
Authors: Zhang Jinghui , Zhang Qing , Xiao Bowen , Cao Yuxuan , Chen Yu , Li Yan 
Published: January 2025

Background
Parental technoference, the interruption of parent-child interactions by technology, has been associated with negative outcomes in children’s media use. However, the magnitude of this relationship and its moderating factors remain unclear.

Objective
This study aims to systematically examine the relationship between parental technoference and child problematic media use, as well as to identify moderating factors such as age, parental technoference group, study design, and type of problematic media use.

Methods
Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a comprehensive literature search was conducted up to August 2024 across multiple databases, including Web of Science, EBSCO, ProQuest, PubMed, PsycINFO, and China National Knowledge Infrastructure, using predefined search strings. A total of 53 studies with a total of 60,555 participants (mean age of 13.84, SD 1.18 years) were included. Inclusion criteria comprised studies involving children under the age of 22 years, assessing the association between parental technoference and child problematic media use with valid measures, and reporting necessary statistical data. Exclusion criteria included studies focusing on other child outcomes, having sample sizes <30, or being case reports or review papers. The risk of bias was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. A random-effects meta-analysis was performed using R (version 4.2.1; R Foundation for Statistical Computing) with the meta and metafor packages to evaluate the association and conduct moderator analyses.

Results
The meta-analysis identified a significant positive association between parental technoference and child problematic media use (r=0.296, 95% CI 0.259-0.331). Moderator analyses revealed that both parental technoference group (P<.001) and study design (P=.008) significantly influenced this relationship. Specifically, the association was stronger when both parents engaged in technoference compared to when only 1 parent did, and in cross-sectional studies compared to longitudinal studies. Age, gender, publication status, and type of problematic media use did not significantly moderate the relationship (all P>.05).

Conclusions
This meta-analysis provides robust evidence of the association between parental technoference and child problematic media use. The findings highlight the need for family-based interventions and underscore the importance of longitudinal research to understand the temporal dynamics of this relationship better.

Trial Registration
PROSPERO CRD42023471997; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=471997
Design and Implementation of Two-phase Boost Inverter using Interleaved Method to Increase Output Current
Authors: Setiyawan Fahrul Indra , Pratomo Leonardus Heru 
Published: January 2025

The advancement of technology is rapidly evolving, particularly in the field of electronics, namely power electronics. One of the applications is the use of new and renewable energy. The converters required in new and renewable energy are inverters with good quality and performance. The step-down (buck) inverter is commonly used in this application. Different from the normal inverter, the step up (boost) inverter is proposed to be analyzed, simulated, and implemented in this paper. The proposed inverter uses a two-phase interleaved boost inverter (TP DC-AC IBI) consisting of a full bridge inverter and dual AC-AC interleaved boost converter. The inverter part always converts DC voltage to AC voltage, while the dual AC-AC interleaved boost converter part serves to increase the output voltage. The inverter consists of three arms: the first and second arms are controlled by Sinusoidal Pulse Width Modulation (SPWM) using 180° phase-shifted carrier signal, and the third arm is controlled by a zero-crossing detector. Pulse Width Modulation (PWM) is used to control dual AC-AC interleaved boost converter. By combining this inverter with dual AC-AC interleaved boost converter, a new topology is created. This study specifically investigated the strategy to control this new topology using current controls. The actual current was obtained by installing an HX-10P current sensor on the output side. The output current was compared with the reference current, and the next stage was controlled using a proportional plus integral controller. The control signals output was modulated using SPWM signals on the inverter side and PWM at the AC-AC interleaved boost converter side to drive many power switches. To guarantee that the desired current control can always be achieved, the actual current and reference current must always match. The proportional plus integral controller was chosen due to its simplicity, high accuracy, and quick response time. The analysis involved verifying simulation tests using Power Simulator (PSIM) software. The hardware implementation was conducted in the laboratory and tested using standardized equipment. A couple of inductors were installed to reduce harmonic current on the output side and obtained THD of 3.3%, which according to the IEEE 519-2014, has met the standard as it was less than 5%. Thus, this new topology can be used in new and renewable energy for its good performance.
ISLAMIC LAW REVIEW OF SHARIA FINANCING SCHEMES AT THE ELECTRIC EMPLOYEE COOPERATIVE OF SUBULUSSALAM CITY, INDONESIA
Authors: Prasetia Agung , Jamhuri  , Yuhasnibar  
Published: January 2025

This paper aims to examine three main aspects related to sharia financing at the State electricity company (Perusahaan Listrik Negara PLN) First, what sharia financing is often used in the KOKARLIS cooperative. Second, what are the challenges and obstacles that occur in the management of Islamic financing in cooperatives (KOKARLIS). Third, and how is the legal review in the practice of Islamic financing in cooperatives (KOKARLIS). To answer these three aspects, this research uses a qualitative approach with a descriptive-analytical method. Data collection is done through primary data obtained through interviews, observation, and documentation, as well as secondary data sourced from related references. The results showed that mudharabah and murabahah contracts are the most commonly used types of financing. However, the lack of understanding of cooperative managers, who are mostly PLN employees, is the main challenge, along with the lack of training related to Islamic financing. From the perspective of Islamic law, practices that are not in accordance with sharia rules have the potential to cause gharar, which is contrary to the principle of justice in muamalah. This research emphasizes the importance of increasing the capacity of cooperative managers through continuous training and education related to the principles and practices of Islamic financing. With a better understanding, it is expected that Koperasi KOKARLIS can eliminate the risk of sharia deviations, increase member confidence, and become a better model of sharia financial management.
Da prática para a teoria e a capacitação para evacuação aeromédica de vítimas de desastres envolvendo agentes químicos, biológicos, radiológicos e nucleares
Authors: Haberland Débora Fernanda , Guilherme Fábio José de Almeida , Kneodler Thais da Silva , Silva Thiago Augusto Soares Monteiro da , Oliveira Alexandre Barbosa de 
Published: January 2025

The Brazilian Air Force carries out aeromedical evacuation (EVAM) of victims of disasters involving chemical, biological, radiological and nuclear agents - CBRN). Objective: to carry out a qualitative analysis on training to work in EVAM that involves CBRN agents in the perception of health professionals with real experiences. Method: qualitative, exploratory and descriptive research, carried out through semi-structured interviews. Results: From the sample studied, it was found that the experiences contributed to the review of training to act in new situations. Preparation for action was considered very good in most evaluations, requiring training with specific equipment and PPE. Conclusion: Updating training is important for team safety and effective care. Implications for health and nursing: the role of the nurse researcher/instructor stood out due to the importance of using research to plan the training and preparation of EVAM in crisis situations, which is a new area of care.
Exploring how attachment insecurities mediate the link between sexual and partnership satisfaction in adolescents and young adults with cancer
Authors: Heyne Svenja , Brock Hannah , Richter Diana , Sender Annekathrin , Rosendahl Jenny , Friedrich Michael , Geue Kristina , Mehnert-Theuerkauf Anja 
Published: January 2025

Background and purpose: Comprehensive data on factors affecting partnership satisfaction among adolescents and young adult (AYA) cancer survivors are limited. Our study examines partnership satisfaction, sexual satisfaction, and attachment insecurities, exploring how attachment-related anxiety and avoidance influence the relationship between sexual and partnership satisfaction across major tumor entities in this population.
Patients and methods: We utilized data from two measurement time points (t1 and t6) of the AYA-LE study, a prospective longitudinal investigation examining the temporal course and associated factors of life satisfaction and psychological distress among AYA cancer survivors. We examined the mediating effect of attachment insecurities (ECR-RD) on the relationship between sexual satisfaction (FLZ-Sex) and partnership satisfaction (PFB), while controlling for sociodemographic and clinical characteristics, in a sample of N = 275 participants.
Results: Higher sexual satisfaction was correlated with lower attachment-related anxiety (r = -0.51, p < 0.001) and lower attachment-related avoidance (r = -0.49, p < 0.001). Both lower attachment-related anxiety and attachment-related avoidance were correlated with higher partnership satisfaction (r = -0.64, p < 0.001 and r = -0.72, p < 0.001, respectively). Sexual satisfaction partially predicted partnership satisfaction of AYA cancer survivors through attachment-related anxiety and attachment-related avoidance while the mediating effect accounted for 75% of the total effect.
Interpretation: The associations between sexual satisfaction, partnership satisfaction, and attachment highlight the need to address emotional and relational aspects in supportive care for AYA cancer survivors. There is a clear need for more targeted studies on attachment patterns, sexual satisfaction, and partnership satisfaction in this specific population to further refine and validate these approaches.
Risk factors for early childhood caries in patients with cleft lip and palate: a descriptive study
Authors: Bella Priskilla Kristiana , Setiawan Asty Samiaty , Putri Fidya Meditia 
Published: January 2025

Introduction: Cleft lip and/or palate is a common congenital defect. Children with this condition often experience abnormalities in the anatomical and morphological structures of the oral cavity, which contribute to poor oral hygiene and a lack of interest in maintaining dental care. Early Childhood Caries (ECC) is a prevalent dental health problem in patients with cleft lip and/or palate and is affected by factors such as sugary food consumption, oral hygiene habits, frequency and use of milk bottles, and parental socioeconomic status. This study aims to identify the risk factors for ECC in children with cleft lip and/or palate. Methods: This study employed descriptive research methods, using interviews with ECC risk factor questionnaires and purposive sampling based on Taro Yamane's formula, resulting in a sample of 91 parents of children diagnosed with cleft lip and/or palate. The questionnaires used in this research had undergone validity and reliability testing. The results were analyzed using frequency distribution. Results: The results of this research showed that most respondents had education level equivalent to junior high school or high school (51.65%). The respondents' average income was below 1.5 million as follows, accounting 47.25% of the sample. All respondents (100%) demonstrated good knowledge of maintaining their children's oral hygiene. However, the majority of respondents provided sweet foods (51.65%) and sweet drinks (43.65%) to their children 1-3 times per day. Additionally, 49.45% of respondents reported giving milk to their children before sleep, and 45,05% indicated that their children sometimes fell asleep eating without brushing teeth. Conclusion: The risk factors for ECC in patients with cleft lip and/or palate include parental education and income, children's habit of sleeping after eating without brushing their teeth, frequency of sugary foods consumption, frequency of formula milk consumption, and the practice of giving milk to children before bedtime.
Relationship between sleep patterns, bedtime and recurrent aphthous stomatitis (RAS) during the COVID-19 pandemic: analytical observational research
Authors: Saputro Septian Adi , Arifta Arum Nur , Medawati Ana , Andriani Ika , Rahmawati Atiek Driana , Femilian Afryla , Perdana Lutfi Putra 
Published: January 2025

Introduction: Recurrent Aphthous Stomatitis (RAS) is an inflammation on the oral mucosa, presenting as recurrent, round, single, or multiple ulcers with well-defined boundaries. Although the exact etiology of RAS remains unknown, several factors are known to contribute to its development. During the COVID-19 pandemic, various problems have arisen, especially among adolescents, including senior high school students, whose sleep patterns-specifically their sleep time, duration, and quality-have been disrupted. These disruptions may weaken their immune system, making them more susceptible to RAS disease. The objective of this study is to analyze the relationship between sleep patterns, bedtime, and the occurrence of RAS during the COVID-19 pandemic. Method: The research design employed was an analytical observational study, with a cross-sectional approach. Purposive sampling was used to select all class XI students of SMA 6 Yogyakarta, based on inclusion and exclusion criteria. The research instruments included the PSQI questionnaire (used to measure sleep patterns, sleep time, sleep duration, and sleep quality) and the RASDX questionnaire (a diagnostic tool for measuring the prevalence of RAS lesions) both administered via Google Forms. Statistical analysis was conducted using the Chi-square test. Results: A total of 58 students (55.8%) experienced RAS, with a higher prevalence among female students. Regarding age, 16-year-old students had the highest incidence of RAS, with 79 students (64.4%) affected. Most respondents, 79 respondents (76%), were reported to have good sleep patterns. The results of the bivariate analysis also revealed a significant relationship between sleep patterns, bedtime, and the occurrence of RAS (p=0.043<0.05). Conclusion: Sleep patterns, bedtime, and the occurrence of RAS were found to be interrelated during the COVID-19 pandemic.
Phytochemical properties and antibacterial activity of green tea leaf extract from gunung gambir jember: an experimental study
Authors: Meilawaty Zahara , Ermawati Tantin , Sari Desi Sandra , Ningsih Indah Yulia , Rachmawati Dessy , Nulend Jenneke Klein 
Published: January 2025

Introduction: Green tea leaves are abundant in bioactive components, including catechins, flavonoids, and polyphenols. These compounds are known for tehir antibacterial, anti-inflammatory, and antioxidant properties. In addition, green tea also contains minerals, such as Calcium, Phosphor, Potassium, Magnesium, and Sulphur. However, the precise mineral content and anti-bacterial properties of green tea from Gunung (Mount) Gambir in Jember Regency are currently unknown. This study aimed to analyze the phytochemical composition and antibacterial activity of green tea leaf extract from Gunung Gambir, Jember. Methods: The bioactive constituents of green tea leaf extract were identified using a UV-Vis spectrophotometer to measure its total flavonoid content (TFC) and total phenolic compounds (TPC). Mineral identification was performed using flame atomic absorption spectrometry. The disc diffusion method was used to assess antibacterial activity by quantifying the diameter of the inhibition zone in cultures of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans treated with green tea leaf extract at concentrations of 3.125%, 6.25%, 12.5%, 25%, 50%, and 100%. Anaerobic conditions were created by incubating the Petri dishes in a desiccator for 24 hours at 37°C. One-Way Anova test was used to analyze the data, and differences were considered statistically significant at p<0.05. Subsequently, a LSD test was carried out (p<0,05). Results: The TPC value was 1.607±0.742 mg GAE/g, while the TFC value was 99.146 ± 0.307 mg GAE/g. Calcium appeared to be the most abundant mineral in the tea extract, measured at 31.65 ppm. The inhibitory power of green tea leaves extract against both bacteria was not significantly different (p>0.05). Conclusion: Green tea leaves extract from Gunung Gambir Jember Regency in Indonesia is rich in phenolic compounds, flavonoids, and certain minerals, such us Phosphor, Calium, Magnesium, Sulphur and Calcium. These constituents are known to possess biological and antibacterial activity against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.