bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occupational Stress Levels and Coping Strategies among Nurses Working in an Urban Metropolis in North Central Nigeria
Authors: Akpor Oluwaseyi A. , Aina Victoria O. , Akpor Oghenerobor B. 
Published: February 2023

Background:
Stress is an important psychological concept that can affect health, well-being, and job performance in negative dimensions.

Objective:
This study investigates stress levels and coping strategies among nurses in selected hospitals in North Central Nigeria.

Methods:
The study employed a multistage sample technique method. The study design was descriptive and cross-sectional, using a quantitative strategy. Data analysis was carried out using descriptive and inferential study statistics.

Results:
Finding shows that the minimum age of the participants was 21–30 years, 87% were female, while 41.1% had 1-5 years of working experience. The study revealed that the highest signs and symptoms of stress experienced by the participants included aches and pain (57.5%) and anxiousness (52.5%). The participants experienced moderate stress. The findings revealed that years of experience (r= 0.631, p= 0.000) were observed to be significantly associated with signs and symptoms of stress. The results showed that age (r= -0.243, p= 0.045), religion (r= 0.165, p= 0.032), and experience of memory problems (r= 0.227, p= 0.003) were observed to show significant association with coping strategies.

Conclusion:
Hence, a conducive work environment should be maintained to promote effective nursing care, while periodic stress assessments and management should be implemented by hospital administrators to aid positive coping strategies among nurses.
Identifying Host Cell Gene Expression Modulation as Potential Markers for SARS-CoV2 Infection
Authors: Soferr Jonathan J. , Guiberson Kate , Steel J. Jordan 
Published: February 2023

Background
The SARSCoV2 emergence in 2019 has caused health, safety, and socioeconomic issues around the world. Current testing prioritizes viral RNA detection, requiring specialized techniques, training, and time periods, resulting in significant testing limitations. Viral infection can cause changes in host cell gene expression, which vary from virus to virus. Recent research suggests SARSCoV2-induced gene expression modulations in infected human cells may be differentiated from expressions elicited by other acute respiratory illnesses. Data in this study highlight specific genes that are differentially expressed during SARSCoV2 infection. This novel application of individual sample analysis in connection with global databases, provides robust data for genes that are specifically modulated during SARSCoV2 infection. This expression profile would be valuable for SARSCoV2 testing, prevention, treatment, and basic virology research.

Methods
Previously collected COVID-19 surveillance-testing samples from cadets at the United States Air Force Academy were used to quantify the expression of 19 target genes using direct primer-mediated qRTPCR. Additionally, samples were analyzed with RNA-seq to assess the different transcriptomes between uninfected and SARSCoV2-infected samples. Results were compared with national databases to confirm agreement with the results.

Results
19 genes were identified to be altered during SARSCoV2 infection using in-lab experimental results. This expression profile matches previous research and may uniquely describe SARSCoV2 infection. The genes expected to be upregulated according to previous research, IL1B, IFI44L, ACE2 & DUX3, were all upregulated. RNA-seq data confirms these results and identified 122 other genes that are significantly different between uninfected and SARSCoV2 infected samples. The results have a 93% agreement rate with national databases.

Conclusion
Despite the availability of vaccines for SARSCoV2, the continual mutation and evolution of the virus, the emergence of novel and increasingly infectious strains, and the anti-vaccine sentiment increase the need for safe and rapid testing alternative options. The expression profile of altered host genes during SARSCoV2 infection could be extremely advantageous to detect and prevent infection, as well as further research efforts for treatment and understanding SARSCoV2 infection.
Role of Medicinal Plants in the Management of Inflammatory Disorders:
An Overview
Authors: Grewal Ajmer Singh , Garg Madhukar , Sharma Abhinav , Bansal Shivam , Grover Rupanshi , Sharma Tanya , Kumari Sapna , Goyal Anju , Bhatia Shiveena , Vaid Lavish , Deswal Geeta 
Published: February 2023

Abstract:
Owing to the enhanced toxicity as well as consequences of allopathic medication, the
research on herbal therapies is developing progressively. As a result, medicinal herbs are
beginning to play a substantial role in the advancement of the dominant therapeutic medications.
Since ancient times, the use of herbs has performed a vital part in human well-being as well in the
invention of cutting-edge pharmaceuticals. Inflammation and related illnesses are a major health
concern for the entire human population. Pain-inducing drugs including opiates, non-steroidal
anti-inflammatory drugs, glucocorticoids, and corticosteroids have severe side effects and these
therapies suffer from the recurrence of symptoms too after discontinuing the treatment. As a
result, the diagnosis along with the advancement of medications with anti-inflammatory properties
is the priority to conquer the drawbacks of the existing therapies. The present review article
provides insight into the literature comprising promising phytochemicals from various medicinal
plants tested through different model systems and employed for alleviating inflammation in
several inflammatory disorders as well as clinical status of the herbal products.
Patient Satisfaction With Speech Recognition in the Exam Room: Exploratory Survey
Authors: Sippel Jeffrey , Podhajsky Tim , Lin Chen-Tan 
Published: February 2023

Background
Medical speech recognition technology uses a microphone and computer software to transcribe the spoken word into text and is not typically used in outpatient clinical exam rooms. Patient perceptions regarding speech recognition in the exam room (SRIER) are therefore unknown.

Objective
This study aims to characterize patient perceptions of SRIER by administering a survey to consecutive patients scheduled for acute, chronic, and wellness care in three outpatient clinic sites.

Methods
We used a microphone and medical speech recognition software to complete the “assessment and plan” portion of the after-visit summary in the patient’s presence, immediately printed the after-visit summary, and then administered a 4-question exploratory survey to 65 consecutive patients in internal medicine and pulmonary medicine clinics at an academic medical center and a community family practice clinic in 2021 to characterize patient perceptions of SRIER. All questions were completed by all participants.

Results
When compared to patients’ recollection of usual care (visits with no microphone and an after-visit summary without an “assessment and plan”), 86% (n=56) of respondents agreed or strongly agreed that their provider addressed their concerns better, and 73% (n=48) agreed or strongly agreed that they understood their provider’s advice better. A total of 99% (n=64) of respondents agreed or strongly agreed that a printed after-visit summary including the “assessment and plan” was helpful. By comparing the “agree” and “strongly agree” responses to the neutral responses, we found that patients felt that clinicians using SRIER addressed their concerns better (P<.001), they understood their clinician’s advice better (P<.001), and receiving a paper summary was helpful (P<.001). Patients were likely to recommend a provider using a microphone based on the Net Promoter Score of 58.

Conclusions
This survey suggests patients have a very positive perception of speech recognition use in the exam room.
The Fatty Liver, Cirrhosis, and Liver Cancer Study (TENDENCY): Protocol for a Multicenter Case-Control Study
Authors: Hussain Yaqza , Bannaga Ayman , Fisher Neil , Krishnamoorthy Ashwin , Kimani Peter , Malik Ahmad , Truslove Maria , Joshi Shivam , Hitchins Megan , Abbasi Abdullah , Corbett Christopher , Brookes Matthew , Randeva Harpal , Than Nwe Ni , Arasaradnam Ramesh P 
Published: February 2023

Background
Hepatocellular cancer (HCC) is associated with high mortality, and early diagnosis leads to better survival. Patients with cirrhosis, especially due to nonalcoholic fatty liver disease and viral hepatitis, are at higher risk of developing HCC and form the main screening group. The current screening methods for HCC (6-monthly screening with serum alpha fetoprotein and ultrasound liver) have low sensitivity; hence, there is a need for better screening markers for HCC.

Objective
Our study, TENDENCY, aims to validate the novel screening markers (methylated septin 9, urinary volatile organic compounds, and urinary peptides) for HCC diagnosis and study these noninvasive biomarkers in liver disease.

Methods
This is a multicenter, nested case-control study, which involves comparing the plasma levels of methylated septin 9 between confirmed HCC cases and patients with cirrhosis (control group). It also includes the comparison of urine samples for the detection of HCC-specific volatile organic compounds and peptides. Based on the findings of a pilot study carried out at University Hospital Coventry & Warwickshire, we estimated our sample size to be 308 (n=88, 29% patients with HCC; n=220, 71% patients with cirrhosis). Urine and plasma samples will be collected from all participants and will be frozen at –80 °C until the end of recruitment. Gas chromatography–mass spectrometry will be used for urinary volatile organic compounds detection, and capillary electrophoresis–mass spectrometry will be used for urinary peptide identification. Real-time polymerase chain reaction will be used for the qualitative detection of plasma methylated septin 9. The study will be monitored by the Research and Development department at University Hospital Coventry & Warwickshire.

Results
The recruitment stage was completed in March 2023. The TENDENCY study is currently in the analysis stage, which is expected to finish by November 2023.

Conclusions
There is lack of effective screening tests for hepatocellular cancer despite higher mortality rates. The application of more sensitive plasma and urinary biomarkers for hepatocellular cancer screening in clinical practice will allow us to detect the disease at earlier stages and hence, overall, improve HCC outcomes.

International Registered Report Identifier (IRRID)
DERR1-10.2196/44264
A narrative review on the beneficial impacts of probiotics on poultry: an updated knowledge
Authors: Al-Otaibi Aljohara M. , Abd El-Hack Mohamed E. , Dmour Saif M. , Alsowayeh Noorah , Khafaga Asmaa F. , Ashour Elwy A. , Nour-Eldeen Mohamed A. , Świątkiewicz Sylwester 
Published: February 2023

Abstract
Probiotics are live microorganisms that can improve the host’s health when given in sufficient doses. Due to growing consumer demand for poultry raised without antibiotics supplementation, the usage of probiotics has been rising gradually over time in poultry. This review aimed to summarize the impacts of probiotics on poultry’s nutrient utilization, growth and carcass parameters, gut morphology, laying performance, biochemical parameters, immunity, and gut microbiota. The results revealed that probiotics enhanced the growth performance via improving digestion of protein, lipids, and carbohydrates, improving feed conversion ratio (FCR), increasing carcass and organs weights, improved liver and kidney function parameters, antioxidant effects, decreased serum lipids and cholesterol, improved poultry immunity via improving gut health and synthesis of antimicrobial peptides and prevention of microbial colonization, improved laying performance, fertility, hatchability and eggshell thickness. Therefore, probiotics have various benefits in poultry production compared to banned antibiotics. However, they are not always guaranteed to be growth promoters due to poorly understood modes of action, including their interaction with the host. So, further studies concerning their impacts on meat quality and histopathological changes are still required.
A Mini-Review on Plant-Derived Phenolic Compounds with Particular Emphasis on Their Possible Applications and Beneficial Uses in Aquaculture
Authors: Naiel Mohammed A.E. , El-Kholy Abdullah I. , Negm Samar S. , Ghazanfar Shakira , Shukry Mustafa , Zhang Zhaowei , Ahmadifar Ehsan , Abdel-Latif Hany M.R. 
Published: February 2023

Abstract
The use of most antibiotics has been restricted and banned in finfish and shrimp farms due to several reasons comprising their long-lasting persistence in aquatic environments, relatively high prices, and their ability to promote the existence of antibiotic-resistant bacteria. Hence, finding economical, natural, and environmentally safe alternatives is of great importance. The use of polyphenols, polyphenol-rich plants, and plant-derived phenolic compounds for promoting aquatic animal health and welfare could be from the effective strategies for developing aquafeed and maintaining the sustainability of the aquaculture industry. Several plants are gorgeous in various bioactive functional ingredients known as phytochemicals and polyphenols. Phenolic compounds could be successfully used as natural immunostimulants in order to raise the immunity of finfish and shrimp species against several bacterial, viral, and parasitic infections and thus may replace the use of antimicrobial agents. Besides their potential roles for improvement of the growth performance, intestinal health, and enhancing the antioxidant capacity of the treated animals. Even though the trend of using plant-derived phenolic compounds is a new and leading era for the improvement of the functionality of aquafeed and the development of the aquaculture industry, there are fundamental needs and necessities to describe a clear understanding of their modes of action and potential roles in the improvement of the production rates, antioxidant activity, immune status, and disease resistance of farmed fish and shrimp.
Effects of Dietary Supplementation with Phytobiotic Encapsulated Plant Extracts on Broilers’ Performance Parameters, Welfare Traits and Meat Characteristics
Authors: Dokou Stella , Vasilopoulou Konstantina , Bonos Eleftherios , Grigoriadou Katerina , Savvidou Soumela , Stefanakis Michalis K. , Christaki Stamatia , Kyriakoudi Anastasia , Mourtzinos Ioannis , Tzora Athina , Giannenas Ilias , Skoufos Ioannis 
Published: February 2023

Abstract
Background: Medicinal plants exhibit significant effects on broiler physiology and production. This trial aimed to evaluate the effects of dietary supplementation with an aqueous or cyclodextrin extract derived from a mixture of Origanum vulgare L., Camelina sativa L. crantz, Crithmum maritimum L., and Allium sativum L. at the level of 0.1% per kg of dry matter (DM) on broiler growth performance, welfare, meat chemical composition, and oxidative stability.
Results: Cyclodextrin treated group presented significantly higher final body weight, while feed intake and FCR were unaffected by the treatments. Both aqueous and cyclodextrin treated groups had significantly lower pododermatitis score compared to the control group. Additionally, both treatment groups presented increased thigh meat protein content and lower fat content, likewise meat color was also positively affected by both treatments. Supplementation of broilers diet with the cyclodextrin extract also resulted in ∑n-3 fatty acids and ∑n-6 fatty acids increase. The PUFA/SFA and H/H ratios were also increased in the thigh meat of both supplemented groups compared to the control group.
Conclusion: The application of aqueous or cyclodextrin extracts yielded positive results on meat composition, and supported growth performance, welfare, and the oxidative status of the chicken meat.
Molecular and morphological characterization of Tylenchus zeae n. sp. (Nematoda: Tylenchida) from Corn (Zea mays) in South Carolina
Authors: Kantor Mihail R. , Handoo Zafar A. , Subbotin Sergei A. , Mowery Joseph D. , Hult Maria N. , Rogers Stephen , Skantar Andrea M. 
Published: February 2023

Abstract
Specimens of a tylenchid nematode were recovered in 2019 from soil samples collected from a corn field, located in Pickens County, South Carolina, USA. A moderate number of Tylenchus sp. adults (females and males) were recovered. Extracted nematodes were examined morphologically and molecularly for species identification, which indicated that the specimens of the tylenchid adults were a new species, described herein as Tylenchus zeae n. sp. Morphological examination and the morphometric details of the specimens were very close to the original descriptions of Tylenchus sherianus and T. rex. However, females of the new species can be differentiated from these species by body shape and length, shape of excretory duct, distance between anterior end and esophageal intestinal valve, and a few other characteristics given in the diagnosis. Males of the new species can be differentiated from the two closely related species by tail, spicules, and gubernaculum length. Cryo-scanning electron microscopy confirmed head bearing five or six annules; four to six cephalic sensilla represented by small pits at the rounded corners of the labial plate; a small, round oral plate; and a large, pit-like amphidial opening confined to the labial plate and extending three to four annules beyond it. Phylogenetic analysis of 18S rRNA gene sequences placed Tylenchus zeae n. sp. in a clade with Tylenchus arcuatus and several Filenchus spp., and the mitochondrial cytochrome oxidase c subunit 1 (COI) gene region separated the new species from T. arcuatus and other tylenchid species. In the 28S tree, T. zeae n. sp. showed a high level of sequence divergence and was positioned outside of the main Tylenchus-Filenchus clade.
General Music Education in a Multi-Ethnic Context, on the Example of State-Run Schools in Poland between the World Wars
Authors: Jeż Agnieszka 
Published: February 2023

Abstract
The paper concerns the presence and ideological identity-building function of Polish folk music in Polish state-run schools between the World Wars, and the experiences of Jewish children and teenagers in this regard. The young Polish state brought together populations from the former three partitioned territories, which included numerous national minorities. The need for bond-forming, powerfully symbolic elements supporting a collectively developed national identity was soon strongly felt. Polish folk music, with particular emphasis on its regional varieties, perfectly fitted into the ideological current of patriotic and civic youth education in both state-run and private schools. Dances and songs which children learned at music and PE lessons familiarised them with the wealth of traditions, imbuing them with pride and the love of national culture. The paper quotes examples of young Jews’ experiences in this context, as they encountered Polish folksongs and dances in state-run schools: their responses to this issue and the impact of such contacts on their identities. The source material comes from pre-WWII press, in which we hear the voices of the children themselves, reporting their experiences.
Three Psalms, Liturgia sacra, Fragments: the Last Works in Zygmunt Mycielski's Oeuvre1
Authors: Bolesławska-Lewandowska Beata 
Published: February 2023

Abstract
In his concept of a composer's creative work Mieczysław Tomaszewski distinguishes the late and final phases. Edward W. Said, on the other hand, devoted his last publication to reflections on the late style in music and literature, referring to the existing body of research on the subject. What is the position, in the context of both these perspectives, of three important works for voices and instruments by Zygmunt Mycielski: Three Psalms, Liturgia sacra, and Fragments to words by Juliusz Słowacki, written in the last few years of the composer's life? The author discusses these works and attempts to answer that question in her conclusion.
Two weeks administration of tranexamic acid for acute intracerebral hemorrhage: A hospital-based pilot study
Authors: Inoue Hirotaka , Kawano Takayuki , Iwasaki Yuri , Imada Izumi , Yamada Kazuhiro , Tashima Kouzo , Muta Daisuke , Yamamoto Keizo , Mukasa Akitake 
Published: February 2023

Background:
A previous report suggested that functional status does not differ between patients who received tranexamic acid and those who received placebo within the early hours of intracerebral hemorrhage (ICH). Our pilot study tested the hypothesis that 2 weeks administration of tranexamic acid would contribute to functional improvement.

Methods:
Consecutive patients with ICH were administered 250 mg tranexamic acid 3 times a day continuously for 2 weeks. We also enrolled historical control consecutive patients. We collected clinical data that involved hematoma size, level of consciousness, and Modified Rankin Scale (mRS) scores.

Results:
Univariate analysis showed that the mRS score on day 90 was better in the administration group (P = 0.0095). The mRS scores on the day of death or discharge suggested a favorable effect of the treatment (P = 0.0678). Multivariable logistic regression analysis also showed that the treatment was associated with good mRS scores on day 90 (odds ratio [OR] = 2.81, 95% confidence interval [CI]: 1.10–7.21, P = 0.0312). In contrast, ICH size was associated with poor mRS scores on day 90 (OR = 0.92, 95% CI: 0.88–0.97, P = 0.0005). After propensity score matching, there was no difference in the outcomes between the two groups. We did not detect mild and serious adverse events.

Conclusion:
The study could not show the significant effect of 2 weeks administration of tranexamic acid on functional outcomes of ICH patients after the matching; however, suggested that this treatment is at least safe and feasible. A larger and adequately powered trial is needed.
A lumbar chondroma originating from the intervertebral disc
Authors: Gonchigar Uma , Cazzolli Taryn , Tavakoli-Sabour Samon , Bartanusz Viktor 
Published: February 2023

Background:
Chondromas, benign cartilaginous primary bone tumors, seldom occur in the spine. Most spinal chondromas arise from the cartilaginous parts of the vertebra. Chondromas originating from the intervertebral disc are extraordinarily rare.

Case Description:
A 65-year-old female experienced recurrence of low back pain and left-sided lumbar radiculopathy after microdiscectomy and microdecompression. A mass continuous with the intervertebral disc was found to be compressing the left L3 nerve root and was resected. Histologic examination revealed a benign chondroma.

Conclusion:
Chondromas developing from the intervertebral disc are extremely rare; we could find only 37 reported cases. Identification of these chondromas is difficult because until surgical resection they are almost indistinguishable from herniated intervertebral discs. Here, we describe a patient with residual/recurrent lumbar radiculopathy caused by a chondroma originating from the L3–4 intervertebral disc. When a patient has recurrence of spinal nerve root compression after discectomy, a chondroma arising from the intervertebral disc is an uncommon but possible etiology.