bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological changes induced by Piroxicam on the hepatic and renal tissues of mice with and without administration of Peppermint oil
Authors: Al-Hamdany Muna , Al-Tai Faten , Ismail Hanaa K. 
Published: January 2023

Abstract
Piroxicam is a popular anti-inflammatory drug that displays palliative and antipyretic activity. Peppermint oil is a common flavoring used in foods and drinks. To investigate the defensive action of Peppermint oil against the hepatic and renal histological damage induced by Piroxicam in mice.
Forty healthy adult Swiss albino mice of both sexes were categorized into 4 groups (10 mice in each group): Control group (I); Treatment group (II) – injected with Piroxicam 0.3 mg/kg/rat/day via intraperitoneal route for 28 days; Treatment group (III) – oral Peppermint oil 0.2 ml/kg/day by oral gavage 24 hours preceding each injection of Piroxicam; Treatment group (IV) oral Peppermint oil alone. Blood samples were withdrawn to estimate the hepatic and renal functions. Immediately after death, specimens of liver and kidney from the four groups were isolated and put in 10% concentration buffered formalin for 24 hours then prepared for light microscopic examination.
There was a highly significant rise in the serum level of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase and total serum bilirubin) in the group treated with Piroxicam, as compared to the control group. These returned to near normal level in the group treated with Piroxicam and Peppermint oil. Liver samples of the treated mice showed ballooning degeneration of hepatocytes, small apoptotic hepatocytes and inflammatory cellular infiltration, whereas kidney sections revealed cystic dilatation of Bowman’s space, shrinkage of glomerular tuft and apoptosis of epithelial cells lining the tubules. In contrast, the addition of peppermint oil efficiently ameliorated the hepatic and renal tissue changes.
Piroxicam induces hepatorenal toxicity as exhibited by histological, histochemical and biochemical findings. Peppermint oil shows ameliorative properties against the hepatorenal toxic effects induced by Piroxicam.
The protective effect of vitamin A on Concor induced structural changes of the liver and kidney in adult rats
Authors: Ahmed Mareb H. , Taeel Faten Dhanoon 
Published: January 2023

Abstract
Concor is a beta-blocker drug used to treat high blood pressure, acute coronary syndrome, and to control the rapid pulse of the heart such as atrial fibrillation. Some of its adverse effects include hepatitis, increased triglycerides and liver enzymes. Monitoring liver and kidney functions in patients with hepatic or renal impairment who are taking concor is recommended.
The current study was undertaken to define whether vitamin A could improve structural changes in the liver and kidneys. The 24 rats were grouped into the following. The first group was control. The second group was given Vitamin A (5000 IU). Group 3: given concor at a daily dose of 0.9 mg/kg B. wt. Group IV: received concor (0.9 mg/kg B. wt.) and Vitamin A (5000 IU) orally. After 4 weeks, the kidney of the treated group 3 exhibited degenerative alterations in the glomeruli, enlargement of Bowman’s space and the epithelium of the proximal kidney tubules showed vacuolar degeneration with necrosis. Liver sections showed degeneration and necrosis of hepatocytes, congestion of the central vein, dilation of sinusoids and inflammatory cell infiltration. Group 4 showed mild degeneration in the glomeruli, expansion of Bowman’s space and mild degeneration of tubular epithelium, and normal architecture of the liver with increased Kupffer cells. From this study, we concluded that concor drug induces structural changes in the liver and kidney and these effects were improved by Vitamin A administration.
Phytochemical analysis and evaluation of antibacterial activity of Moringa oleifera extracts against gram-negative bacteria: an in vitro and molecular docking studies
Authors: Ganjo Aryan R. , Adham Aveen N. , Al-Bustany Hazem A. , Aka Safaa T. 
Published: January 2023

Abstract

Moringa oleifera seed and leaf are used traditionally for the treatment of various health problems (among others, hypertension, scrapes, skin infection, diabetes, genitourinary illnesses), and to boost the immune system, as well as to act as a contraceptive. In this study, the antibacterial activity of seed and leaf M. oleifera extracts on three-gram negative bacteria was investigated, and phytochemical analysis for the association of antibacterial activity with the active constituents in the plant was determined. Moreover, understanding of the mechanism of action was achieved by applying the Auto Dock Vina technique. The phytochemical screening of M. oleifera seed and leaf extracts exhibited the presence of alkaloids, carbohydrates, cardioactive glycosides, flavonoids, tannins, phenols, steroids and terpenoids. In silico results revealed that compounds (4-O-caffeoyl quinic acid, 4-(α-L-rhamnopyranosyloxyl)-benzylisothiocyanate); (Isoquercitrin, 4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate); and (Astragalin, 4-(α-L-rhamnopyranosyloxy) benzyl glucosinolate) from leaf and seed have the highest binding affinity and very good interactions with Transcriptional Activator Protein (LasR), Klebsiella pneumoniae carbapenemase (KPC), and Malonyl-CoA-acyl carrier protein transacylase (FabD), respectively.
Determination of β-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant
Authors: Traczuk Adam , Polak Beata 
Published: January 2023

Abstract
Eight drugs blocking beta-adrenergic receptors activity (acebutolol, alprenolol, atenolol, oxprenolol, labetalol, metoprolol, propranolol and sotalol) were investigated through the use of the thin-layer technique with its mobile phase containing surfactant. Assessment of the effect of surfactant presence and 1-propanol concentration in the mobile phase on the retention and separation of investigated solutes was then carried out wherein the effect of the surfactant concentration on the zone shape properties (asymmetry and tailing coefficient) was investigated. The method was applied for the quantitative analysis of the chosen solutes, and the LOD and LOQ values of chosen were determined. These were as follows: acebutolol – 1.11 and 3.36 μg/spot, metoprolol 1.45 μg/spot, 4.4 μg/spot. The chosen system is environmentally friendly due to using silica gel plates and only 5% of propanol in water.
A ANÁLISE SARTRIANA SOBRE A CONSTRUÇÃO EGO DO ESCRITOR JEAN GENET FRENTE A SUA LIBERDADE
Authors: Erculino Siloe Cristina do Nascimento , Rangel Silênia de Azevedo Silveira 
Published: January 2023

A partir da psicanálise existencial sartriana, descrita na obra Saint Genet: Ator e Mártir, analisaremos os caminhos tortuosos que a subjetividade percorre na tentativa de se plenificar como objeto. Nosso propósito é demonstrar que Genet buscou identificar-se com seu ego para se colocar como um objeto de desprezo para a sociedade, porém, sua busca fracassa, pois, segundo Sartre, o homem jamais será completamente objetividade alienada no mundo. Nesse intuito, descreveremos brevemente os principais momentos da vida de Genet. Em sua infância, teve seu ego-visto (ser-para-outro) constituído pelo olhar de outrem; a partir de então, realizou diversos esforços para se identificar com essa imagem alienada, entretanto - enquanto liberdade -, permaneceu frente a todas as suas tentativas de fixar um ego maldito com o qual se identificasse; e, por fim, encontrou apenas a sua própria subjetividade, exercendo sua liberdade no ofício de escritor. Concluiremos, portanto, que a subjetividade permanece livre e responsável, mesmo frente à construção do seu ego.
Urgensi Pendidikan Politik di Provinsi Aceh Studi Kasus: Politik Uang dalam Pemilu di Kota Sabang
Authors: Kelana Edy Putra , Rahmad Rahmad , Murniyanti Sri , Ernalis Fitri , Novialdi Risky 
Published: January 2023

Considering the fact that the practice of money politics is deeply embedded in people's lives, from the grassroots to the top, this complex issue must be taken seriously. An issue that seems trivial but has enormous negative implications for the development of democracy and law enforcement (Supremacy) in Indonesia. Money politics biases the political process. Due to money, it is difficult for elections to show the characteristics of honesty, fairness and fair competition. Elections like this end up creating a government that doesn't think about the fate and welfare of the people. The purpose of this study is to find out the urgency of political education in the province of Aceh. Case study: money politics in elections in the city of Sabang. The method used in this research is qualitative method. the survey results obtained 47% of respondents said they prioritized work, then 2% of respondents said they did not believe in election participants and prioritized work, there were 9% of respondents who did not believe in election participants, and there were 4% of respondents who did not believe in political parties and election participants, 27% of respondents did not believe in political parties and 2% of respondents said they were not registered and did not believe in political parties, and 9% of respondents were not registered on the final voter list (DPT).
النقد الشکلاني والمدونة التراثیة الاسلامیة بین الواقع اللغوی والجمالیة الادبیة
Authors: حسن اعظمی خویرد أ.م.د. , قاسم عزيزي مراد أ.م.د 
Published: January 2023

إذا کانت النظریات النقدیة الحدیثة قد تساءلت عن الأدب ألا یمکن الذهاب إلی أنّ النقد القدیم أیضا تساءل عن الأدب و الأدبیة، و حاول أن یجد له أجوبة مقنعة و هذا ما جعلنا نختار عملیة فهم النص علی ضوء مدرسة الشکلانیین في التراث الإسلامي والتي تهتمّ بالأدبیة بوصفها عنصراً رئیساً في الجمالیة الأدبیّة. فعبد القاهر الجرجاني، وأبوهلال العسکري، وقدامة بن جعفر علی الصعید الثقافي ــ النقدي قد یمکن أن ینظر إلیهم علی أنّهم ینطلقون من المنطلق الشکلاني وعلی هذا الأساس کان التفکیر في تناوله کموضوع، یسعی إلی الإسهام في بلورة فکر نقدي بلاغي في تراثنا القدیم، من محاولة الإجابة علی السؤال المهم الذي طرح علی بساط البحث في الثقافة الغربیة، وهو ما الذي یجعل من النص نصّاً أدبیّاً؟ هذا السؤال إذن هو الإشکالیة التي نبحث لها عن إجابة في المدونة التراثیة، منها نظریة النظم و التي یمکننا أن نطلق علیها " قراءة شکلیّة فنیّة" تبحث عن النص من الواقع اللغوي الذي سیطر علی آراء سیبویه و قدجاء هؤلاء بهذه النظریة آخذین آراءهم من عنده. وقد وصل المقال في نهایة المطاف إلی أنّ القراءة الشکلیة الفنیة هي المنهج المهیمن علی التراث الإسلامي و هو یعني الاهتمام بالثقافة الواحدة التي یمکن أن تتعایش تحت ظلالها شعوب مختلفة.
علّة المؤانسة في الصّرف العربيّ
Authors: عامر زهير جودة العبداني د. 
Published: January 2023

تناول هذا البحث علة المؤانسة في الصرف العربي ، والتعليل أحد أركان القياس التي يبني عليها الحكم الصرفي ، ومعلوم أن ما جاء معللا أقبل إلى العقل ممّا جاء بدون علة ، والمؤانسة يراد بها أن كل تغيير يلحق بنية الكلمة مؤنس بتغيير سابق أي أن كثرة التغييرات في بنية الكلمة تبيح التغييرات مؤانسة بالتغيير ، وعلة المؤانسة أوّل ما وردت في شرح الكتاب للرماني ( ت 384 ه ) ، ثم وردت بعد ذلك في مؤلفات اللغويين ملازمة للتغيير والإعلال حتى أن القدماء قالوا أن التغيير يؤنس بالتغيير ، وقد درست قضايا الصرف التي اعتمدت علة المؤنسة في توجيه أحكامها الصرفية وتشمل : ( النسب ، والإعلال ، والتثنية ، وجمع التكسير) .
الخوف في زمن الأوبئة كورونا انموذجا
Authors: زينب محمد صالح العزاوي أ. م.د 
Published: January 2023

Most religions adopt a set of rituals, the purpose of
تتبنى معظم الاديان مجموعة من الطقوس الهدف منها خلق روابط حسية وروحية وبعث الاطمئنان ودرء الخوف الاجتماعي الذي قد يصيب المجتمع بأكمله. و يسعى الانسان دوما الى خلق نفس مطمئنة من خلال ممارسات عديدة كتقبيل احجار مقدسة او تقديم لفائف التوراة وكتب الصلاة كما يشرب الجميع من نفس الكأس في القداس المسيحي ولكن بعد انتشار الجائحة بشكل مخيف شهد العالم بأكمله تغير شامل في اجندات الاديان فلم تعد الطقوس والممارسات الدينية تأخذ مكانها من المجتمعات وذلك خوفا من انتشار الوباء مما ادى الى ارتفاع نسبة القلق والخوف لكل مجتمعات العالم باسرها. من هنا كان الزاما على الباحثين ان يبحث في نمو هذه الظاهرة وكيف كان لها الاثر البالغ في قلب الموازيين في كل المجتمعات ولقد تطرق البحث الى مبحثين المبحث الاول اجندة الاديان وجائحة كورونا والمبحث الثاني الجائحة في المجتمعات المأزومة وسبل معالجتها.
وقد تم هيكلة البحث حسب المباحث الآتية :
المبحث الاول : مشكله واهميه واهداف البحث .
المبحث الثاني : المصطلحات والمفاهيم العلمية للبحث .،
المبحث الثالث : تناول العادات والتقاليد الدينية التي لغيت جراء الخوف من هذا الوباء.
ثم تطرق البحث الى تأثيرات جائحة كورونا في خلق الاضطرابات النفسية عندما يواجه الانسان اي خطر خاصة اذا كان الخطر وباء عالمي ثم ذهب البحث الى بيان ماهية الازمة التي خلفتها كورونا وما هي انواعها واسبابها. ثم بيان اهم المناهج لتشخيص الازمات وكيفية دراستها ومراحل نمو الازمة واهم المعوقات التي تعرقل ادارة الازمة.
ثم خرج البحث بأهم ما توصلت له من نتائج وبعض التوصيات الهامه .
Mucinous neoplasms of the appendix - A clinicopathologic study of 21 cases with special insight into current classification & controversies.
Authors: Rajashree Pradhan  , Sajeeb Mondal  , Mrinal Sikdar  , Abhishek Bandyopadhyay  
Published: January 2023

Background : Appendiceal mucinous neoplasms are rare and heterogenous disease which often clinically present as appendicitis. There are many controversies regarding the classification of mucinous neoplasms of the appendix.
Aims and Objectives: Our aim of this study was to study different types of mucinous neoplasms of appendix based on current ( WHO 2019) classification, their clinical and radiological presentations and controversies regarding their diagnosis.
Materials and Methods: This was a retrospective study done in a tertiary care hospital. We studied clinical presentations of 21 cases along with the histopathological study of respective appendectomy specimens .
Results: Out of 21 cases, 3 (14.28%) cases were serrated polyp, 9 cases (42.85%) were Low grade appendiceal mucinous neoplasm (LAMN), 3 cases (14.28%) were high grade appendiceal neoplasm (HAMN) and 6 (28.57%) cases were mucinous adenocarcinoma. In this study we have discussed in brief about regarding the current classification and controversies of appendiceal mucinous neoplasms.
Conclusion: Mucinous neoplasms of the appendix are complex lesions with many controversies. Oversimplification in the recent classification may add to more complexity. Reintroduction of the old terminology of Mucinous Tumour of Uncertain Malignant Potential might save histopathologists from potential litigation.
ESPECIARIAS E ERVAS FRESCAS: ALGUMAS NOTAS A PARTIR DOS ESTUDOS NA GASTRONOMIA
Authors: Silva Beatriz Coelho , Cunha Iana Cândido , Degani Isis Pereira Coutinho , Santos Maria de Lurdes Alves , Santos Jean Carlos Vieira 
Published: January 2023

O presente estudo objetiva promover uma análise acerca do uso de ervas frescas e especiarias na gastronomia, ao adotar a metodologia da revisão literária integrativa com abordagem descritiva. A gastronomia configura-se como um método de extrema importância na preparação de alimentos, visto que sua proposta consiste em proporcionar prazer e associar a qualidade do alimento com as sensações despertadas por quem o experimenta. Diante disso, um dos aspectos mais relevantes da gastronomia refere-se à utilização das ervas frescas e especiarias, algo fundamental para realçar tanto o sabor quanto o odor dos alimentos e auxiliar na digestão e na estética da finalização dos pratos. Não obstante, deve-se observar que o emprego indiscriminado das especiarias em combinações e quantidades exageradas pode comprometer o resultado final da preparação.
Palavras-chave: Ervas Frescas; Especiarias; Utilização; Gastronomia.
Does the Global Alignment and Proportion score predict mechanical complications in circumferential minimally invasive surgery for adult spinal deformity?
Authors: Gendelberg David , Rao Arya , Chung Andrew , Jimenez-Almonte Jose H. , Anand Anita , Robinson Jerry , Khandehroo Bardia , Khandehroo Babak , Kahwaty Sheila , Anand Neel 
Published: January 2023

OBJECTIVE
The Global Alignment and Proportion (GAP) score was developed to serve as a tool to predict mechanical complication probability in patients undergoing surgery for adult spinal deformity (ASD), serving as an aid for setting surgical goals to decrease the prevalence of mechanical complications in ASD surgery. However, it was developed using ASD patients for whom open surgical techniques were used for correction. Therefore, the purpose of this study was to assess the applicability of the score for patients undergoing circumferential minimally invasive surgery (cMIS) for correction of ASD.

METHODS
Study participants were patients undergoing cMIS ASD surgery without the use of osteotomies with a minimum of four levels fused and 2 years of follow-up. Postoperative GAP scores were calculated for all patients, and the association with mechanical failure was analyzed.

RESULTS
The authors identified 182 patients who underwent cMIS correction of ASD. Mechanical complications were found in 11.1% of patients with proportioned spinopelvic states, 20.5% of patients with moderately disproportioned spinopelvic states, and 18.8% of patients with severely disproportioned spinopelvic states. Analysis with a chi-square test showed a significant difference between the cMIS and original GAP study cohorts in the moderately disproportioned and severely disproportioned spinopelvic states, but not in the proportioned spinopelvic states.

CONCLUSIONS
For patients stratified into proportioned, moderately disproportioned, and severely disproportioned spinopelvic states, the GAP score predicted 6%, 47%, and 95% mechanical complication rates, respectively. The mechanical complication rate in patients undergoing cMIS ASD correction did not correlate with the calculated GAP spinopelvic state.
En bloc resection of ligamentum flavum with laminotomy of the caudal lamina in the minimally invasive laminectomy: surgical anatomy and technique
Authors: Tumialán Luis M. 
Published: January 2023

OBJECTIVE
A CSF leak is a potential complication in a lumbar laminectomy. An analysis of the author’s surgical experience identified inadvertent durotomies that occurred when resecting the ligamentum flavum at its insertion into the superior aspect of the caudal lamina. Anatomical analyses of the lumbar canal diameter demonstrate that the insertion point of the caudal ligamentum flavum is the most constrained area of the canal. The surgical technique was modified to eliminate the need for direct action in that anatomical region after the author compared the efficacy of piecemeal resection of the ligamentum flavum with en bloc resection with a laminotomy of the caudal lamina beyond the insertion point of the ligamentum flavum in the lumbar laminectomy.

METHODS
An analysis of a single surgeon’s experience managing 147 consecutive patients with lumbar stenosis who underwent single-level lumbar hemilaminectomies over a 4-year period was performed. Patients were managed with either piecemeal resection (cohort 1) or en bloc resection with a laminotomy beyond the caudal insertion (cohort 2) of the ligamentum flavum.

RESULTS
Seventy-seven patients underwent piecemeal resection (cohort 1), and 70 underwent en bloc resection (cohort 2). There were 5 CSF leaks (6.4%) in cohort 1. There were no CSF leaks in cohort 2. There was a statistically significant difference in operative times between the two groups (p = 0.04), but there was no statistically significant difference in patient-reported outcomes at 6 months between the groups.

CONCLUSIONS
En bloc resection of the ligamentum flavum with a laminotomy below the caudal insertion point appears to decrease the risk of a CSF leak by working beyond the most constrained diameter of the lumbar canal to release the caudal insertion of the ligamentum flavum.
Radiographic alignment outcomes after the single-position prone transpsoas approach: a multi-institutional retrospective review of 363 cases
Authors: Diaz-Aguilar Luis , Stone Lauren E. , Soliman Mohamed A. R. , Padovano Alexander , Ehresman Jeff , Brown Nolan J. , Produturi Gautam , Battista Madison , Khan Asham , Pollina John , Amaral Rodrigo , Abd-El-Barr Muhammad M. , Moss Isaac , Smith Tyler , Deol Gurvinder S. , Lee Bryan S. , McMains M. Craig , . Joseph Samuel A , Schwartz David , Pimenta Luiz , Nguyen Andrew D. , Taylor William R. 
Published: January 2023

OBJECTIVE
The aim of this paper was to evaluate the changes in radiographic spinopelvic parameters in a large cohort of patients undergoing the prone transpsoas approach to the lumbar spine.

METHODS
A multicenter retrospective observational cohort study was performed for all patients who underwent lateral lumber interbody fusion via the single-position prone transpsoas (PTP) approach. Spinopelvic parameters from preoperative and first upright postoperative radiographs were collected, including lumbar lordosis (LL), pelvic incidence (PI), and pelvic tilt (PT). Functional indices (visual analog scale score), and patient-reported outcomes (Oswestry Disability Index) were also recorded from pre- and postoperative appointments.

RESULTS
Of the 363 patients who successfully underwent the procedure, LL after fusion was 50.0° compared with 45.6° preoperatively (p < 0.001). The pelvic incidence–lumbar lordosis mismatch (PI-LL) was 10.5° preoperatively versus 2.9° postoperatively (p < 0.001). PT did not significantly change (0.2° ± 10.7°, p > 0.05).

CONCLUSIONS
The PTP approach allows significant gain in lordotic augmentation, which was associated with good functional results at follow-up.
Improvement following minimally invasive transforaminal lumbar interbody fusion in patients aged 70 years or older compared with younger age groups
Authors: Shahi Pratyush , Dalal Sidhant , Shinn Daniel , Song Junho , Araghi Kasra , Melissaridou Dimitra , Sheha Evan , Dowdell James , Iyer Sravisht , Qureshi Sheeraz A. 
Published: January 2023

OBJECTIVE
The goal of this study was to assess the outcomes of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) in patients ≥ 70 years old and compare them to younger age groups.

METHODS
This was a retrospective study of data that were collected prospectively. Patients who underwent primary single-level MI-TLIF were included and divided into 3 groups: age < 60, 60–69, and ≥ 70 years. The outcome measures were as follows: 1) patient-reported outcome measures (PROMs) (i.e., visual analog scale [VAS] for back and leg pain, Oswestry Disability Index [ODI], 12-Item Short-Form Health Survey Physical Component Summary [SF-12 PCS]); 2) minimum clinically important difference (MCID) achievement; 3) return to activities; 4) opioid discontinuation; 5) fusion rates; and 6) complications/reoperations.

RESULTS
A total of 147 patients (age < 60 years, 62; 60–69 years, 47; ≥ 70 years, 38) were included. All the groups showed significant improvements in all PROMs at the early (< 6 months) and late (≥ 6 months) time points and there was no significant difference between the groups. Although MCID achievement rates for VAS leg and ODI were similar, they were lower in the ≥ 70-year-old patient group for VAS back and SF-12 PCS. Although the time to MCID achievement for ODI and SF-12 PCS was similar, it was greater in the ≥ 70-year-old patient group for VAS back and leg. There was no significant difference between the groups in terms of return to activities, opioid discontinuation, fusion rates, and complication/reoperation rates.

CONCLUSIONS
Although patients > 70 years of age may be less likely and/or take longer to achieve MCID compared to their younger counterparts, they show an overall significant improvement in PROMs, a similar likelihood of returning to activities and discontinuing opioids, and comparable fusion and complication/reoperation rates following MI-TLIF.