bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothetical 22-Year Intervention With the Dietary Approaches to Stop Hypertension and Risk of Heart Failure in a General Population
Authors: Ibsen Daniel B , Chiu Yu-Han , Gémes Katalin , Wolk Alicja 
Published: September 2023

Abstract
We used design principles of target trial methodology to emulate the effect of sustained adherence to the Dietary Approaches to Stop Hypertension (DASH) diet on the 22-year risk of heart failure. Women and men aged 45–83 years without previous heart failure, who answered questionnaires in 1997 from the Swedish Mammography Cohort and the Cohort of Swedish Men, were eligible. Follow-up questionnaires were sent in 2008–2009. Incidence of heart failure was ascertained using the Swedish Patient Register, updated until December 31, 2019. The parametric g-formula was used to estimate the 22-year risk of heart failure under sustained adherence to a population-adapted DASH diet compared with no intervention. Intakes before 1997 for before-baseline adjustment was available only for women. In total, 31,238 women and 34,939 men were eligible. The 22-year risk of heart failure was 14.5% with long-term adherence to the DASH diet compared with 15.2% with no intervention (risk difference = −0.7%, 95% confidence interval: 1.6, 0.0%) in women and correspondingly in men 15.3% vs. 16.2% (risk difference = −0.9%, 95% confidence interval: −1.6, −0.2%). Our hypothetical intervention suggests that sustained adherence to the population-adapted DASH diet may reduce risk of heart failure in middle-aged and elderly Swedish women and men.
Tau-PET abnormality as a biomarker for Alzheimer’s disease staging and early detection: a topological perspective
Authors: Ding Jie , Shen Chushu , Wang Zhenguo , Yang Yongfeng , El Fakhri Georges , Lu Jie , Liang Dong , Zheng Hairong , Zhou Yun , Sun Tao ,   For the Alzheimer’s Disease Neuroimaging Initiative and the Harvard Brain Aging Study
Published: September 2023

Abstract
Alzheimer’s disease can be detected early through biomarkers such as tau positron emission tomography (PET) imaging, which shows abnormal protein accumulations in the brain. The standardized uptake value ratio (SUVR) is often used to quantify tau-PET imaging, but topological information from multiple brain regions is also linked to tau pathology. Here a new method was developed to investigate the correlations between brain regions using subject-level tau networks. Participants with cognitive normal (74), early mild cognitive impairment (35), late mild cognitive impairment (32), and Alzheimer’s disease (40) were included. The abnormality network from each scan was constructed to extract topological features, and 7 functional clusters were further analyzed for connectivity strengths. Results showed that the proposed method performed better than conventional SUVR measures for disease staging and prodromal sign detection. For example, when to differ healthy subjects with and without amyloid deposition, topological biomarker is significant with P &lt; 0.01, SUVR is not with P &gt; 0.05. Functionally significant clusters, i.e. medial temporal lobe, default mode network, and visual-related regions, were identified as critical hubs vulnerable to early disease conversion before mild cognitive impairment. These findings were replicated in an independent data cohort, demonstrating the potential to monitor the early sign and progression of Alzheimer’s disease from a topological perspective for individual.
Proton pump inhibitors and adverse kidney outcomes during immune checkpoint blockade: time to sound the alarm?
Authors: Tan Hui Zhuan , Sprangers Ben 
Published: September 2023

Abstract
Immune checkpoint inhibitors (ICIs) have significantly altered the treatment landscape for cancer in the last decade. However, their benefits are often offset by therapy-limiting immune-related adverse events (irAEs). Acute interstitial nephritis (AIN) is the most common renal irAE, but the exact mechanisms underlying its development are poorly understood. ICI-induced immune activation against drug-derived antigens, leading to an inflammatory response within the kidney interstitium, has been postulated, evidenced by current observations of a higher incidence of ICI-associated AIN in patients receiving AIN-inducing drugs such as proton pump inhibitors (PPIs). The role of PPIs in this specific context has garnered significant attention, given their ubiquitous use and sometimes misuse. In this issue of CKJ Miao et al. summarise and synthesize the best available evidence to clarify the interactions of PPIs with ICIs in the development of AIN and other adverse kidney outcomes. The sum of evidence provided appear to implicate PPIs in the development of clinically significant short- and long-term kidney-related adverse effects in patients on immune checkpoint blockade, although causality cannot be proven. In this editorial we discuss the key practical implications of these findings and emphasize the need for further quality studies to delineate the true relationship of ICIs and PPIs in the development of AIN.
Reproducing complex anisotropy patterns at subduction zones from splitting intensity analysis and anisotropy tomography
Authors: Confal Judith M , Baccheschi Paola , Pondrelli Silvia , Karakostas Foivos , VanderBeek Brandon P , Huang Zhouchuan , Faccenda Manuele 
Published: September 2023

SUMMARYMeasurements of seismic anisotropy provide a lot of information on the deformation and structure as well as flows of the Earth's interior, in particular of the upper mantle. Even though the strong and heterogeneous seismic anisotropic nature of the upper mantle has been demonstrated by a wealth of theoretical and observational approaches , most of standard teleseismic body-wave tomography studies overlook P- and S-wave anisotropy, thus producing artefacts in tomographic models in terms of amplitude and localization of heterogeneities. Conventional methods of seismic anisotropy measurement have their limitations regarding lateral and mainly depth resolution. To overcome this problem much effort has been done to develop tomographic methods to invert shear wave splitting data for anisotropic structures, based on finite-frequency sensitivity kernels that relate model perturbations to splitting observations. A promising approach to image the upper mantle anisotropy is the inversion of splitting intensity (SI). This seismic observable is a measure of the amount of energy on the transverse component waveform and, to a first order, it is linearly related to the elastic perturbations of the medium through the 3-D sensitivity kernels, that can be therefore inverted, allowing a high-resolution image of the upper mantle anisotropy. Here we present an application of the SI tomography to a synthetic subduction setting. Starting from synthetic SKS waveforms, we first derived high-quality SKS SI measurements; then we used the SI data as input into tomographic inversion. This approach enables high-resolution tomographic images of upper-mantle anisotropy through recovering vertical and lateral changes in anisotropy and represents a propaedeutic step to the real cases of subduction settings. Additionally this study was able to detect regions of strong dipping anisotropy by allowing a 360° periodic dependence of the splitting vector.
Synergy between polypyrrol and benzoic acid against antibiotic-resistant Salmonella spp
Authors: Garcez Dino César Pereira , Ribeiro Gabrielle , Kominkiewicz Marcelo , da Costa Mateus Matiuzzi , Chideroli Roberta Torres , Rosa Danillo Sales , dos Santos Isaac Emanuel Pereira , Morante Vitor Hugo Penariol , Silveira Simone , Girardini Lilian Kolling 
Published: September 2023

Abstract

Aims
The purpose was to characterize Salmonella Heidelberg (SH) and Minnesota (SM) isolates in terms of their resistance and persistence profile and to assess the antimicrobial effect of benzoic acid (BA) and polypyrrole (PPy).

Methods and results
The 20 isolates from broiler litter drag swabs were submitted to antibiogram and efflux pump expression. The minimum inhibitory/bactericidal concentration (MIC/MBC) of the compounds, synergistic activity, time kill, biofilm production, presence of related genes, and molecular docking between compounds and bacterial target sites were evaluated. All isolates showed multidrug resistance (MDR) and BA and PPy showed mean MIC (1750 and 342 µg ml−1) and MBC (3167 and 1000 µg ml−1), respectively. None of the isolates expressed an efflux pump. The compounds showed synergism against an SH isolate and reduced the count by 3 logs in the presence of the compounds after 4 h. Most isolates (16/20) produced weak to moderate biofilm and 17 showed genes related to biofilm. The compounds interacted with two essential proteins, 3,4-dihydroxy-2-butanone 4-phosphate synthase proteins and ferritin-like domain-containing protein, in bacterial metabolism at different target sites.

Conclusions
It can be concluded that BA and PPy showed activity on SH and SM, MDR, and biofilm producers, with a potential synergistic effect.
Integrative analyses of the mRNA expression profile reveal the involvement of STC1 in chicken folliculogenesis
Authors: Sun Junwei , Zhang Pengwei , Wang Dongxue , Zhu Shuaipeng , Ma Xiangfei , Du Zhenwei , Zhang Jiechang , Yang Shuangyuan , Huang Hetian , Jiang Ruirui , Tian Yadong , Li Wenting , Kang Xiangtao , Yan Fengbin , Sun Guirong , Li Donghua 
Published: September 2023

Abstract
Efficient ovarian follicle development, maturation, and ovulation are critical for egg production performance. Previous research has underscored the importance of messenger RNAs (mRNAs) in regulating development and folliculogenesis in chicken ovarians. However, the molecular mechanism is not fully understood, especially in the late period of the laying cycle. In the present study, ovarian tissues from 80-week-old Hy-Line Brown layers (three with high and three with low rates of egg laying) were collected for transcriptome sequencing. A total of 306 differentially expressed genes (DEGs) were identified in this study, at a false discovery rate (FDR)-corrected P-value &lt; 0.05 and a log2|fold change| (log2|FC|) ≥1.5. Among these DEGs, stanniocalcin 1 (STC1) was mainly related to cellular processes, single-organism processes, biological regulation, metabolic processes, developmental processes, and reproductive processes. Then, we further investigated the regulation of STC1 during chicken follicle development and found that STC1 inhibited the proliferation and stimulated the apoptosis of follicular granulosa cells (GCs), and decreased the expression of progesterone (P4) and estradiol (E2). Collectively, these results suggest that STC1 plays an important role in chicken follicle development by decreasing GC proliferation and steroidogenesis and stimulating GC apoptosis. This study contributes to the understanding of the reproductive biology of laying hens in the late period of the laying cycle and further lays a foundation for the improvement of egg production in poultry breeding.
Judge Bias in Labor Courts and Firm Performance
Authors: Cahuc Pierre , Carcillo Stéphane , Patault Bérengère , Moreau Flavien 
Published: September 2023

Abstract
This paper documents the existence of judge-specific differences on granting compensation for wrongful dismissal and shows that their consequences are different for small low-performing firms than for other firms. Pro-worker judge bias reduces job creation for all firms, increases the destruction of permanent jobs in small and low-performing firms but reduces it in large high-performing firms. Pro-worker bias reduces employment and survival for small and low-performing firms but has no significant effects on these outcomes for the other firms. The probability that permanent incumbent workers keep their job in firms judged by a pro-worker judge increases in large and high-performing firms, while it decreases in small, poorly performing firms.
A novel Bacillus sp. with antagonistic activity against a plant pathogen, Fusarium graminearum, and its potential antagonistic mechanism
Authors: Shen Shanrui , Yu Feifan , Hao Xinyi , Chen Jing , Gao Huan , Lai Xiaofang 
Published: September 2023

Abstract
Fusarium head blight (FHB) is a wheat disease caused by the plant pathogen Fusarium graminearum, which leads to crop yield losses and agricultural economic losses, as well as poses a threat to the environment and human health. Effective biocontrol of F. graminearum is urgent. An antagonistic strain HZ-5 with 59.2% antagonistic activity against F. graminearum in vitro had been isolated from sea mud of Haizhou Bay using a dual-culture assay, which was highly homologous with Bacillus halosaccharovorans according to the 16S rRNA sequence. The antagonistic activity of HZ-5 had been further studied. HZ-5 had a broad range of antagonistic activity against another six plant pathogenic fungi and was effective in controlling FHB of wheat in pot experiment. The substances with antagonistic activity were temperature insensitive, and had been purified by HPLC (High Performance Liquid Chromatography) to prove to be secreted lipopeptides. The antagonistic substances induced the biosynthesis of chitin and glycerol, while ergosterol , cholesterol, and phosphatidylcholine reduced their inhibitory effects on F. graminearum. These data would be helpful to provide a better biocontrol strain against FHB, and to provide important basis to elucidate the antagonistic mechanism of biocontrol.
The Comparative Effectiveness and Provider-induced Demand Collaboration Project: A Pioneering Military-Civilian Academic Partnership to Build Health Services Research Capacity for the Military Health System
Authors: Koehlmoos Tracey Pérez , Madsen Cathaleen , Banaag Amanda , Mitro Jessica Pope , Schoenfeld Andrew J , Learn Peter A , Cooper Zara , Weissman Joel S 
Published: September 2023

ABSTRACT

Introduction
Like civilian health systems, the United States Military Health System (MHS) confronts challenges in achieving the aims of reducing cost, and improving quality, access, and safety, but historically has lacked coordinated health services research (HSR) capabilities that enabled knowledge translation and iterative learning from its wealth of data. A military–civilian academic partnership called the Comparative Effectiveness and Provider-Induced Demand Collaboration (EPIC), formed in 2011, demonstrated early proof-of-concept in using the MHS claims database for research focused on drivers of variation in health care. This existing partnership was reorganized in 2015 and its topics expanded to meet the need for HSR in support of emerging priorities and to develop current and HSR capacity within the MHS.

Materials and Methods
A Donabedian framework of structure, process, and outcomes was applied to support the project, through a core of principal investigators, researchers, analysts, and administrators. Within this framework, new researchers and student trainees learn foundations of HSR while performing secondary analysis of claims data from the MHS Data Repository (MDR) focusing on Health and Readiness, Pediatrics, Policy, Surgery, Trauma, and Women’s Health.

Results
Since 2015, the project has trained 25 faculty, staff, and providers; 51 students and residents; 21 research fellows across multiple disciplines; and as of 2022, produced 107 peer-reviewed publications and 130 conference presentations, across all five themes and six cores. Research results have been incorporated into Federal and professional policy guidelines. Major research areas include opioid usage and prescribing, value-based care, and racial disparities. EPIC researchers provide direct support to MHS leaders and enabling expertise to clinical providers.

Conclusions
EPIC, through its Donabedian framework and utilization of the MHS Data Repository as a research tool, generates actionable findings and builds capacity for continued HSR across the MHS. Eight years after its reorganization in 2015, EPIC continues to provide a platform for capacity building and knowledge translation.
Intelligent monitoring and diagnosis of telescope image quality
Authors: Hu Tianzhu , Zhang Yong , Yan Jiaqi , Liu Ou , Wang Huaiqing , Cui Xiangqun 
Published: September 2023

ABSTRACT
The imaging quality of a telescope directly affects the reliability of astronomical research. Through the monitoring and diagnosis of imaging quality, the cause of the deterioration of imaging quality can be found in time, which is essential for ensuring the peaking performance of the telescope and high-quality imaging. Moreover, these operations are complex and crucial for achieving high-quality imaging of future giant telescope systems involving active optics, adaptive optics, and other advanced techniques. We propose a three-component method based on cutting-edge artificial intelligence technology to real-time monitor and efficiently diagnose the telescope image quality. The first component, an image quality monitoring system, monitors and outputs the telescope’s image quality. The second component is a query system with a knowledge graph, which outputs the node chains as the possible cause of poor image quality based on the input. The third component, a final estimator, uses the node parameter, which contains historical fault data and real-time updated data from sensors, to give the probability of each node chain. We construct and test the system in the Large Sky Area Multi-Object Fiber Spectroscopy Telescope.
Stellar wind yields of very massive stars
Authors: Higgins Erin R , Vink Jorick S , Hirschi Raphael , Laird Alison M , Sabhahit Gautham N 
Published: September 2023

ABSTRACT
The most massive stars provide an essential source of recycled material for young clusters and galaxies. While very massive stars (VMSs, M&gt;100 $\rm {\rm M}_{\odot }$) are relatively rare compared to O stars, they lose disproportionately large amounts of mass already from the onset of core H-burning. VMS have optically thick winds with elevated mass-loss rates in comparison to optically thin standard O-star winds. We compute wind yields and ejected masses on the main sequence, and we compare enhanced mass-loss rates to standard ones. We calculate solar metallicity wind yields from MESA stellar evolution models in the range 50–500 $\rm {\rm M}_{\odot }$, including a large nuclear network of 92 isotopes, investigating not only the CNO-cycle, but also the Ne–Na and Mg–Al cycles. VMS with enhanced winds eject 5–10 times more H-processed elements (N, Ne, Na, Al) on the main sequence in comparison to standard winds, with possible consequences for observed anticorrelations, such as C–N and Na–O, in globular clusters. We find that for VMS 95 per cent of the total wind yields is produced on the main sequence, while only ∼ 5 per cent is supplied by the post-main sequence. This implies that VMS with enhanced winds are the primary source of 26Al, contrasting previous works where classical Wolf–Rayet winds had been suggested to be responsible for galactic 26Al enrichment. Finally, 200 $\rm {\rm M}_{\odot }$ stars eject 100 times more of each heavy element in their winds than 50 $\rm {\rm M}_{\odot }$ stars, and even when weighted by an IMF their wind contribution is still an order of magnitude higher than that of 50 $\rm {\rm M}_{\odot }$ stars.
Revisiting the properties of GW190814 and its formation history
Authors: Lyu F , Yuan L , Wu D H , Guo W H , Wang Y Z , Yi S X , Tang Q W , Hu R-C , Zhu J-P , Shu X W , Qin Y , Liang E W 
Published: September 2023

ABSTRACT
GW190814 was reported during LIGO’s and Virgo’s third observing run with the most asymmetric component masses (an ∼23 M⊙ black hole and an ∼2.6 M⊙ compact object). Under the assumption that this event is a binary black hole (BBH) merger formed through the isolated binary evolution channel, we reanalyse the publicly released data of GW190814 with the modified astrophysical priors on the effective spin χeff, and further explore its formation history using detailed binary modelling. We show that GW190814 is likely to have been formed through the classical common envelope channel. Our findings show that the properties inferred using the modified astrophysical priors are consistent with those inferred by the uniform priors. With the newly inferred properties of GW190814, we perform detailed binary evolution of the immediate progenitor of the BBH (namely a close binary system composed of a BH and a helium star) in a large parameter space, taking into account mass-loss, internal differential rotation, supernova kicks, and tidal interactions between the helium star and the BH companion. Our findings show that GW190814-like events could be formed in limited initial conditions just after the common envelope phase: an ∼23 M⊙ BH and a helium star of MZamsHe ∼ 8.5 M⊙ at solar metallicity (∼ 7.5 M⊙ at 10 per cent solar metallicity) with an initial orbital period at around 1.0 d. Additionally, the inferred low spin of the secondary indicates that the required metallicity for reproducing GW190814-like events should not be too low (e.g. Z ≳ 0.1 Z⊙).
The filament determination depends on the tracer: comparing filaments based on dark matter particles and galaxies in the gaea semi-analytical model
Authors: Zakharova Daria , Vulcani Benedetta , De Lucia Gabriella , Xie Lizhi , Hirschmann Michaela , Fontanot Fabio 
Published: September 2023

ABSTRACT
Filaments are elongated structures that connect groups and clusters of galaxies and are visually the striking feature in cosmological maps. In the literature, typically filaments are defined only using galaxies, assuming that these are good tracers of the dark matter distribution, despite the fact that galaxies are a biased indicator. Here, we apply the topological filament extractor disperse to the predictions of the semi-analytical code GAlaxy Evolution and Assembly to investigate the correspondence between the properties of z = 0 filaments extracted using the distribution of dark matter and the distribution of model galaxies evolving within the same large-scale structure. We focus on filaments around massive clusters with a mass comparable to Virgo and Coma, with the intent of investigating the influence of massive systems and their feeding filamentary structure on the physical properties of galaxies. We apply different methods to compare the properties of filaments based on the different tracers and study how the sample selection impacts the extraction. Overall, filaments extracted using different tracers agree, although they never coincide totally. We also find that the number of filaments ending up in the massive clusters identified using galaxy distribution is typically underestimated with respect to the corresponding dark matter filament extraction.
Lithium depletion in solar analogs: age and mass effects
Authors: Rathsam Anne , Meléndez Jorge , Carvalho Silva Gabriela 
Published: September 2023

ABSTRACT
The main goal of this work is to evaluate the correlation between Li abundance, age, and mass. Using high-quality ESO/HARPS data (R ≃ 115 000; 270 ≤ SNR ≤ 1000), we measured Li abundances via spectral synthesis of the 6707.8 Å 7Li line in 74 solar twins and analogs. Our joint analysis of 151 Sun-like stars (72 from our sample plus 79 solar twins from a previous study) confirms the strong Li abundance–age correlation reported by other works. Mass and convective envelope size also seem to be connected with Li abundance but with lower significance. We have found a link between the presence of planets and low Li abundances in a sample of 192 stars with a high significance. Our results agree qualitatively with non-standard models, and indicate that several extra transport mechanisms must be taken into account to explain the behaviour of Li abundance for stars with different masses and ages.