bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Econometric Analysis of Economic Development and CO2 Emissions in India
Authors: Devi Tilka , Sirohi Rajeev 
Published: February 2023

Purpose: The purpose of this article is to investigate the impact of economic development on the environment. Using time series data from 1991 to 2019, GDP per capita and CO2 emissions are utilised as indicators of economic development and environmental degradation, respectively.
Design/Methodology/Approach: PP and ADF unit root tests verify variable stationarity. Econometric study using Johansen cointegration test and vector error correction model (VECM) and residual stability model.
Findings: Study revealed that long-run association among Carbon dioxide emissions, gross domestic product per capita, and industrial Value added. Carbon dioxide emissions increased with the rised in the Gross domestic product per capita. GDP per capita was outcomes to be unfavorably related to Carbon dioxide emissions in India.
Research Limitations/Implications: This study was suggest that environmental degradation can be reduced at the cost of economic development. Energy-efficient technologies should be encouraged to enhance the domestic product with the help of the industrial sector by improving environmentally friendly technologies from advanced economies. This study suggests the need for environmental policies to reduce emissions during periods of economic growth.
Originality/Value: This paper used new econometric methods to study the relationship between economic development and environmental degradation in India year 1991 to 2019.
Strong Self‐Trapped Exciton Emission and Highly Efficient Near‐Infrared luminescence in Sb3+‐Yb3+ Co‐doped Cs2AgInCl6 Double Perovskite
Authors: Cao Luyu , Jia Xiaofang , Gan Weijiang , Ma Chong‐Geng , Zhang Junying , Lou Bibo , Wang Jing 
Published: February 2023

AbstractYb3+ doped lead‐free double perovskites (DPs) with near‐infrared (NIR)‐emitting have attracted extensive attention due to their wide application prospects. Unfortunately, they still suffer from weak NIR emission due to undesirable resonance energy transfer between the sensitizers and Yb3+ ions. Herein, a new effective NIR‐emitting DP is developed by co‐doping Sb3+ and Yb3+ into Cs2AgInCl6. Experiments and theoretical calculations reveal that induced by co‐doping Sb3+ ions, the self‐trapped excitation (STE) emission intensity of Cs2AgInCl6 is greatly enhanced by 240 times, and the STE emission shifts from 600 nm to 660 nm, which contributes to a larger spectral overlap between STE emission and the absorption of Yb3+ ions. As a result, the absolute NIR photoluminescence quantum yield reaches an unprecedented 50% in lead‐free DPs via high‐efficiency STE sensitization (>30%). The excellent optical performance of Cs2AgInCl6: Sb, Yb with high ambient, thermal and light stability makes it suitable for application in night‐vision devices. Moreover, an ingenious dual‐modal optical information encryption based on the combination of visible and NIR fluorescence printing patterns utilizing Cs2AgInCl6: Sb and Cs2AgInCl6: Sb, Yb respectively is successfully demonstrated. This study provides inspiration for designing highly efficient NIR‐emitting Ln3+‐doped DPs and illustrates their great potential in versatile optoelectronic applications.
Multifunctional Organohydrogel with Ultralow‐Hysteresis, Ultrafast‐Response, and Whole‐Strain‐Range Linearity for Self‐Powered Sensors
Authors: Zou Jian , Jing Xin , Chen Zhuo , Wang Sheng‐Ji , Hu Xiang‐Shu , Feng Pei‐Yong , Liu Yue‐Jun 
Published: February 2023

AbstractThe conductive hydrogels always suffered from high internal friction, large hysteresis, and low capability of accurately predicting physical deformation, which seriously restricted their application in smart wearable devices. To address these problems, solvent molecules are directionally inserted into the polymer molecule chains via bridge effect to effectively reduce the molecular internal friction. Moreover, swelling is also combined to eliminate the temporary entanglements in the hydrogel system. The cooperation between the bridge and swollen effect endows the prepared polyacrylamide (PAM)/laponite/H3BO3/ethylene glycol (Eg) organohydrogel (PLBOH) ultralow hysteresis (1.38%, ε = 100%), ultrafast response (≈10 ms), and high linearity in the whole‐strain‐range (R2 = 0.996) with a great sensitivity (GF = 2.68 at the strain range of 0–750%). Meanwhile, the prepared PL10B30OH exhibits long‐term stability, excellent stretchability, and low dissipated energy. Furthermore, the assembled triboelectric nanogenerator (TENG) displays an outstanding energy harvesting performance with an output voltage of 200 V with the size of 20 mm × 20 mm. The assembled strain sensors can monitor the small strain of facial expressions and large strain of human movements, indicating the tremendous applications in self‐powered intelligent and flexible wearable electronics under harsh environmental conditions.
Microfluidics‐enabled Serial Assembly of Lipid‐siRNA‐sorafenib Nanoparticles for Synergetic Hepatocellular Carcinoma Therapy
Authors: Chen Yao , Zhao Dong , Xiao Feng , Li Xuanyu , Li Jia'an , Su Zhenwei , Jiang Xingyu 
Published: February 2023

AbstractMulti‐component nanoparticles (mNPs) hold great potential for disease prevention and treatment. However, a major barrier is the lack of versatile platforms to accommodate steps of assembly processes of mNPs. Here the microfluidics‐enabled serial assembly (MESA) of mNPs is presented. The microfluidic chip, as a mini‐conveyor of initial materials, sequentially enables the assembly of sorafenib supramolecule, electrostatic adsorption of siRNA, and surface assembly of protective lipids. The produced lipid‐siRNA‐sorafenib nanoparticles (LSS NPs) have ultrahigh encapsulation efficiencies for sorafenib (≈100%) and siRNA (≈95%), which benefit from the accommodation of both fast and slow processes on the chip. Although carrying negative charges, LSS NPs enable cytosolic delivery of agents and high gene silencing efficiency within tumor cells. In vivo, the LSS NPs delivering hypoxia‐induced factor (HIF1α)‐targeted siRNA efficiently regress tumors of Hep3B xenograft and hepatocellular carcinoma patient‐derived primary cells xenograft (PDCX) and finally extend the average survival of PDCX mice to 68 days. Thus, this strategy is promising as a sorafenib/siRNA combination therapy, and MESA can be a universal platform for fabricating complex nanosystems.
Formation Mechanism of Elemental Te Produced in Tellurite Glass Systems by Femtosecond Laser Irradiation
Authors: Torun Gözden , Kishi Tetsuo , Pugliese Diego , Milanese Daniel , Bellouard Yves 
Published: February 2023

AbstractThe formation of elemental trigonal tellurium (t‐Te) on tellurite glass surfaces exposed to femtosecond laser pulses is discussed. Specifically, the underlying elemental crystallization phenomenon is investigated by altering laser parameters in common tellurite glass compositions under various ambient conditions. Elemental crystallization of t‐Te by a single femtosecond laser pulse is unveiled by high‐resolution imaging and analysis. The thermal diffusion model reveals the absence of lattice melting upon a single laser pulse, highlighting the complexity of the phase transformation. The typical cross‐section displays three different crystal configurations over its depth, in which the overall thickness increases with each subsequent pulse. The effect of various controlled atmospheres shows the suppressing nature of the elemental crystallization, whereas the substrate temperature shows no significant impact on the nucleation of t‐Te nanocrystals. This research gives new insight into the elemental crystallization of glass upon femtosecond laser irradiation and shows the potential to fabricate functional transparent electronic micro/nanodevices.
Implicit Perception of Differences between NLP‐Produced and Human‐Produced Language in the Mentalizing Network
Authors: Wei Zhengde , Chen Ying , Zhao Qian , Zhang Pengyu , Zhou Longxi , Ren Jiecheng , Piao Yi , Qiu Bensheng , Xie Xing , Wang Suiping , Liu Jia , Zhang Daren , Kadosh Roi Cohen , Zhang Xiaochu 
Published: February 2023

AbstractNatural language processing (NLP) is central to the communication with machines and among ourselves, and NLP research field has long sought to produce human‐quality language. Identification of informative criteria for measuring NLP‐produced language quality will support development of ever‐better NLP tools. The authors hypothesize that mentalizing network neural activity may be used to distinguish NLP‐produced language from human‐produced language, even for cases where human judges cannot subjectively distinguish the language source. Using the social chatbots Google Meena in English and Microsoft XiaoIce in Chinese to generate NLP‐produced language, behavioral tests which reveal that variance of personality perceived from chatbot chats is larger than for human chats are conducted, suggesting that chatbot language usage patterns are not stable. Using an identity rating task with functional magnetic resonance imaging, neuroimaging analyses which reveal distinct patterns of brain activity in the mentalizing network including the DMPFC and rTPJ in response to chatbot versus human chats that cannot be distinguished subjectively are conducted. This study illustrates a promising empirical basis for measuring the quality of NLP‐produced language: adding a judge's implicit perception as an additional criterion.
Cholesterol‐Amino‐Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self‐Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice
Authors: Du Shi , Li Wenqing , Zhang Yuebao , Xue Yonger , Hou Xucheng , Yan Jingyue , Cheng Jeffrey , Deng Binbin , McComb David W. , Lin Jennifer , Zeng Hong , Cheng Xiaolin , Irvine Darrell J. , Weiss Ron , Dong Yizhou 
Published: February 2023

AbstractMale infertility caused by genetic mutations is an important type of infertility. Currently, there is no reliable method in the clinic to address this medical need. The emergence of mRNA therapy provides a possible strategy for restoring mutant genes in the reproductive system. However, effective delivery of mRNA to spermatocytes remains a formidable challenge. Here a series of cholesterol‐amino‐phosphate (CAP) lipids are reported by integrating three bioactive moieties into a geometric structure, which is favorable for mRNA delivery. The results demonstrate that CAP‐derived lipid nanoparticles (CAP LNPs) can deliver RNA including traditional mRNA and self‐amplifying RNA (saRNA) encoding DNA Meiotic Recombinase 1 (Dmc1) protein in spermatocytes and treat male infertility caused by the Dmc1 gene mutation. Notably, the delivery efficiency of CAP LNPs is significantly higher than that of the MC3 and ALC‐0315 LNPs, which is consistent with the design of CAP molecules. More importantly, a single injection of CAP LNPs–saRNA can produce Dmc1 protein for an extended period, which restores the spermatogenesis in the Dmc1 gene knockout mouse model. Overall, this study proves the concept of LNPs for the delivery of mRNA to spermatocytes, which provides a unique method to probe male infertility caused by the genetic mutation.
A discriminative event‐based model for subtype diagnosis of sporadic Creutzfeldt‐Jakob disease using brain MRI
Authors: Venkatraghavan Vikram , Pascuzzo Riccardo , Bron Esther E. , Moscatelli Marco , Grisoli Marina , Pickens Amy , Cohen Mark L. , Schonberger Lawrence B. , Gambetti Pierluigi , Appleby Brian S. , Klein Stefan , Bizzi Alberto 
Published: February 2023

AbstractIntroductionSporadic Creutzfeldt‐Jakob disease (sCJD) comprises multiple subtypes (MM1, MM2, MV1, MV2C, MV2K, VV1, and VV2) with distinct disease durations and spatiotemporal cascades of brain lesions. Our goal was to establish the ante mortem diagnosis of sCJD subtype, based on patient‐specific estimates of the spatiotemporal cascade of lesions detected by diffusion‐weighted magnetic resonance imaging (DWI).MethodsWe included 488 patients with autopsy‐confirmed diagnosis of sCJD subtype and 50 patients with exclusion of prion disease. We applied a discriminative event‐based model (DEBM) to infer the spatiotemporal cascades of lesions, derived from the DWI scores of 12 brain regions assigned by three neuroradiologists. Based on the DEBM cascades and the prion protein genotype at codon 129, we developed and validated a novel algorithm for the diagnosis of the sCJD subtype.ResultsCascades of MM1, MM2, MV1, MV2C, and VV1 originated in the parietal cortex and, following subtype‐specific orderings of propagation, went toward the striatum, thalamus, and cerebellum; conversely, VV2 and MV2K cascades showed a striatum‐to‐cortex propagation. The proposed algorithm achieved 76.5% balanced accuracy for the sCJD subtype diagnosis, with low rater dependency (differences in accuracy of ± 1% among neuroradiologists).DiscussionAnte mortem diagnosis of sCJD subtype is feasible with this novel data‐driven approach, and it may be valuable for patient prognostication, stratification in targeted clinical trials, and future therapeutics.Highlights
Subtype diagnosis of sporadic Creutzfeldt‐Jakob disease (sCJD) is achievable with diffusion MRI.
Cascades of diffusion MRI abnormalities in the brain are subtype‐specific in sCJD.
We proposed a diagnostic algorithm based on cascades of diffusion MRI abnormalities and demonstrated that it is accurate.
Our method may aid early diagnosis, prognosis, stratification in clinical trials, and future therapeutics.
The present approach is applicable to other neurodegenerative diseases, enhancing the differential diagnoses.
Outcome measures for Alzheimer's disease: A global inter‐societal Delphi consensus
Authors: Ellison Tim S. , Cappa Stefano F. , Garrett Dawne , Georges Jean , Iwatsubo Takeshi , Kramer Joel H. , Lehmann Maryna , Lyketsos Constantine , Maier Andrea B. , Merrilees Jennifer , Morris John C. , Naismith Sharon L. , Nobili Flavio , Pahor Marco , Pond Dimity , Robinson Louise , Soysal Pinar , Vandenbulcke Mathieu , Weber Christopher J. , Visser Pieter Jelle , Weiner Michael , Frisoni Giovanni B. 
Published: February 2023

AbstractIntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome.MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non‐voting chair, used a Delphi approach and modified GRADE criteria.ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment‐related outcomes; Medical investigations; Disease‐related life events; and Global outcomes.DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.
Unveiling Talbot Effect under Fresnel Diffraction at a Fork‐Shaped Grating
Authors: Ikonnikov Denis A. , Myslivets Sergey A. , Davletshin Nikolay N. , Baron Filipp A. , Arkhipkin Vasily G. , Vyunishev Andrey M. 
Published: February 2023

AbstractThe near‐field effect of diffraction image self‐reproduction or self‐imaging of a periodic grating illuminated by quasi‐monochromatic wave is well‐known as the Talbot effect. Introducing a dislocation to a periodic structure provides a fork‐shaped modulation of the phase/amplitude, which produces discrete diffraction pattern in a far‐field consisting of optical vortices. In this paper, Fresnel diffraction at amplitude fork‐shaped grating is theoretically and experimentally studied. The coexistence of spatial ordering and local violation of translational symmetry of the structure manifests itself in a strict diffraction pattern consisting of optical vortices in the far‐field, which is shown to be accompanied by formation of a spatially ordered intensity distribution in the near‐field, reminiscent the Talbot carpets for periodic structures. These results demonstrate the first evidence of Talbot effect occurred under light diffraction at fork‐shaped gratings, being promising for deep understanding of near‐field singular optics phenomena.
Carboxylic‐Phosphoric Anhydrides as Direct Electrophiles for Decarbonylative Hirao Cross‐Coupling of Carboxylic Acids: DFT Investigation of Mechanistic Pathway
Authors: Liu Chengwei , Xing Yang‐Yang , Zhou Tongliang , Chen Tieqiao , Hong Xin , Szostak Michal 
Published: February 2023

AbstractIn this anniversary issue, we present a DFT study of the mechanism of decarbonylative Hirao cross‐coupling of carboxylic‐phosphoric anhydrides to afford aryl phosphonates. Traditionally, the direct activation of carboxylic acids to participate in decarbonylative couplings is performed in the presence of carboxylic acid anhydride activators. We discovered that direct dehydrogenative decarbonylative phosphorylation of benzoic acid can be performed in high yield via dehydrogenative and decarbonylative coupling in the presence of phosphite as dual activating and nucleophilic reagent, enabling direct decarbonylative phosphorylation. Control studies demonstrated that carboxylic‐phosphoric anhydride (acyl phosphate) is an intermediate in this process. DFT studies were conducted to gain insight into this decarbonylative process and compare the selectivity of C−O and P−O bond activations. Considering the utility of ubiquitous carboxylic acids, this alternative activation pathway may find applications in decarbonylative coupling of carboxylic acids for the synthesis of valuable molecules in organic synthesis.
Electroacupuncture alleviates pain after total knee arthroplasty through regulating neuroplasticity: A resting‐state functional magnetic resonance imaging study
Authors: Kang Bingxin , Zhao Chi , Ma Jie , Wang Haiqi , Gu Xiaoli , Xu Hui , Zhong Sheng , Gao Chenxin , Xu Xirui , A Xinyu , Xie Jun , Du Mengmeng , Shen Jun , Xiao Lianbo 
Published: February 2023

AbstractIntroductionWe aimed to evaluate the efficacy of electroacupuncture in relieving acute pain after total knee arthroplasty (TKA) and related mechanism.MethodsIn this randomized, single‐blind, and sham‐acupuncture controlled study. Forty patients with postoperative acute pain were recruited and randomly divided electroacupuncture group (n = 20) and sham‐acupuncture group (n = 20) from November 2020 to October 2021. All patients received electroacupuncture or sham‐acupuncture for 5 days after TKA. Their brain regions were scanned with resting‐state functional magnetic resonance imaging before and after intervention. Pain was scaled. Another 40 matched healthy controls underwent scanning once. The amplitude of low‐frequency fluctuation (ALFF) values was compared. Pearson's correlation analysis was utilized to explore the correlation of ALFF with clinical variables in patients after intervention.ResultsCompared with the HCs, patients with acute pain following TKA had significantly decreased ALFF value in right middle frontal gyrus, right supplementary motor area, bilateral precuneus, right calcarine fissure and surrounding cortex, and left triangular part of inferior frontal gyrus (false discovery rate corrected p < .05). Patients had higher ALFF value in bilateral precuneus, right cuneus, right angular gyrus, bilateral middle occipital gyrus, and left middle temporal gyrus after electroacupuncture (AlphaSim corrected p < .01). Correlation analysis revealed that the change (postoperative day 7 to postoperative day 3) of ALFF in bilateral precuneus were negatively correlated with the change of NRS scores (r = −0.706; p = .002; 95% CI = −0.890 to −0.323) in EA group.ConclusionsThe functional activities of related brain regions decreased in patients with acute pain after TKA. The enhancement of the functional activity of precuneus may be the neurobiological mechanism of electroacupuncture in treating pain following TKA.
Where “culture wars” and therapy meet: Exploring the intersection between political issues and therapeutic practice
Authors: Farrar Nicola , Hanley Terry 
Published: February 2023

AbstractIn the era of “culture wars,” instances where client and practitioner discuss political issues in therapy may become more frequent. This paper introduces the way in which “culture wars” manifest in today's societies and highlights the importance of therapeutic practitioners to engage with and explore their own views in relation to these polarising political debates. In doing so, this paper reflects upon the existing research focussing on the way in which “culture wars” enter the therapeutic encounter and highlights the feelings of anxiety and conflict that arise when practitioners are tasked with “talking politics” with clients. It considers the implications for practice and policy and concludes with recommendations for future scholarship, arguing for more culturally specific studies that examine how “culture wars” issues impact therapeutic work in a variety of international settings.
Activating Blood Circulation, Anti‐Inflammatory and Diuretic Effects of Leonurus japonicus Extract on a Rat Model of Trauma Blood Stasis and Its Phytochemical Profiling
Authors: Zhang Shengyuan , Nie Hua , Yang Yali , Yang Li , He Junwei 
Published: February 2023

AbstractLeonurus japonicus Houtt. has been traditionally used to treat many ailments. This study evaluated the activating blood circulation, anti‐inflammatory, and diuretic effects of L. japonicus extract (LJ) and identified its phytochemicals. In this work, the phytochemicals in LJ were identified using liquid chromatography mass spectrometry. Rats were randomly assigned to three groups (n=8): Control group was treated with saline, while the Model group (saline) and LJ group (426 mg/kg) had induced traumatic injury. All rats were treated with once by daily oral gavage for one week. The biochemical indices and protein expression were measured. Herein, 79 constituents were identified in LJ, which were effective in elevating body weight, food consumption, water intake, and urinary excretion volume, as well as in ameliorating traumatic muscle tissues in model rats. In addition, LJ prominently decreased the contents of plasma viscosity, platelet aggregation rate, thrombin time, prothrombin time, activated partial thromboplastin time, fibrinogen, thromboxane B2 (TXB2), TXB2/6‐keto‐prostaglandin F1α (6‐keto‐PGF1α), urokinase‐type plasminogen activator (u‐PA), plasminogen activator inhibitor 1 (PAI‐1), PAI‐1/tissue‐type PA (t‐PA), and PAI‐1/u‐PA, while significantly increasing antithrombin III, 6‐keto‐PGF1α, and t‐PA contents. Furthermore, LJ notably inhibited tumor necrosis factor alpha, interleukin 6 (IL‐6), IL‐8, angiotensin II, antidiuretic hormone, aldosterone, aquaporin 1 (AQP1), AQP2, and AQP3 levels, and markedly elevating IL‐10 and natriuretic peptide levels. Finally, LJ markedly reduced the protein expression of AQP1, AQP2, and AQP3 compared to the model group. Collectively, LJ possessed prominent activating blood circulation, anti‐inflammatory, and diuretic effects, thus supporting the clinical application of L. japonicus.