bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood opportunity and residential instability: associations with mental health in middle childhood
Authors: Putnick Diane L. , Tyris Jordan , McAdam Jordan , Ghassabian Akhgar , Mendola Pauline , Sundaram Rajeshwari , Yeung Edwina 
Published: January 2025

BackgroundNeighborhood quality may contribute to child mental health, but families with young children often move, and residential instability has also been tied to adverse mental health. This study's primary goal was to disentangle the effects of neighborhood quality from those of residential instability on mental health in middle childhood.Methods1,946 children from 1,652 families in the Upstate KIDS cohort from New York state, US, were followed prospectively from birth to age 10. Residential addresses were linked at the census tract level to the Child Opportunity Index 2.0, a multidimensional indicator of neighborhood quality. The number of different addresses reported from birth to age 10 was counted to indicate residential instability, and the change in COI quintile indicated social mobility. Parents completed three assessments of attention‐deficit/hyperactivity disorder, problematic behavior, and internalizing psychopathology symptoms at ages 7, 8, and 10. Child and family covariates were selected a priori to adjust sample characteristics, increase estimate precision, and account for potential confounding.ResultsIn unadjusted models, higher neighborhood quality at birth was associated with fewer psychopathology symptoms in middle childhood, but associations were largely mediated by residential instability. In adjusted models, residential instability was associated with more psychopathology symptoms, even accounting for social mobility. Neighborhood quality at birth had indirect effects on child mental health symptoms through residential instability.ConclusionsChildren born into lower‐quality neighborhoods moved more, and moving more was associated with higher psychopathology symptoms. Findings were similar across different timings of residential moves, for girls and boys, and for children who did not experience a major life event. Additional research is needed to better understand which aspects of moving are most disruptive to young children.
Plastics in dermatology: A review and solutions
Authors: Tan Eugene , Saha Susanne , Niebel Dennis 
Published: January 2025

AbstractHazards to human and planetary health are present at every stage of the plastic life cycle, yet plastic production is projected to triple by 2060. This review focuses on three key areas: the life cycle of plastic, the impact of microplastics and their associated chemicals, along with recommendations to reduce plastic use. In dermatology, micro‐ and nanoplastics are especially problematic as they are present in over 90% of personal care products. They have been detected in utero, absorbed through the skin and found in the lungs and gastrointestinal tract. Numerous in vitro and animal studies have substantiated the negative impact of micro‐ and nanoplastics but gaps remain with regards to their effect on human health. In spite of this limitation, we review the evidence to date and offer evidence‐based recommendations which can reduce plastic production, enhance health outcomes and promote environmental justice.
When A Political Sinner Does A Good Deed: The Role of Government Officials' Stigma Anxiety in Granting Political Access
Authors: Chang Yuyuan , Li Shuping 
Published: January 2025

AbstractThis study examines when firms with damaged political reputations – political officials' negative perceptions of a firm's capabilities and character – attempt to restore their reputations and regain political access through an essential form of Corporate Political Activities (CPA), Corporate Social Responsibility (CSR). We focus on the officials' incentives and introduce the concept of stigma anxiety, which refers to officials' concerns about being associated with reputationally damaged firms. Analysing 3531 Chinese firms from 2012 to 2020 in the context of China's anticorruption campaigns, we find that officials are less likely to grant political access to firms with damaged political reputations. However, CSR activities may mitigate these adverse effects. The effectiveness of CSR activities in regaining political access is further influenced by officials' stigma anxiety, shaped by three factors: controllability (the extent to which a stigmatized actor is perceived as responsible for the stigma), disruptiveness (the degree to which stigma is perceived as a threat to others), and visibility (the extent to which a stigma event stands out and attracts sustained attention). Our findings contribute to research on CPA, stigma, and CSR.
LIMA1 Is a Prognostic Senescence‐Inhibitory Gene in Head and Neck Squamous Carcinoma
Authors: You Yuanhe , Du Zhong , Tian Zhuowei , Yu Fan , Li Shunshun , He Jie , Xiao Meng , Wang Yanan 
Published: January 2025

ABSTRACTBackgroundThis study aimed to investigate potential cellular senescence inhibitory genes (CSIGs) and discover novel therapeutic targets in head and neck squamous cell carcinoma.MethodsDysregulated CSIGs were identified based on The Cancer Genome Atlas (TCGA) and the Human Aging Genomic Resources (HAGR) database. Prognostic value and immune infiltration were assessed through bioinformatic analysis. Cell proliferation was evaluated using CCK‐8, Edu assay, and colony formation assays in vitro. Western blotting and real‐time PCR were used to evaluate LIMA1 expression. Clinical validation of LIMA1 expression was performed in our validated cohort.ResultsIn this study, differential analysis and functional enrichment analysis identified 26 differentially expressed senescence inhibitory genes. Among them, LIMA1 was found to be an independent prognostic marker and associated immune infiltration. Knockdown of LIMA1 inhibited HNSCC cell growth and increased the expression of senescence markers. Further experiments revealed that LIMA1 expression was partially regulated by the IL6/STAT3 signaling pathway. Immunohistochemistry further validated the clinical significance of LIMA1 expression and its association with IL6 and CD8+ T cells in our hospital's HNSCC tissues.ConclusionLIMA1 is a prognostic senescence‐inhibitory gene in HNSCC. The IL6/STAT3/LIMA1 axis represents a novel molecular mechanism underlying cellular senescence resistance in HNSCC.
An Essential Component of Any Policy Toolkit to Address Federal Budget Deficits: Tax Expenditure Reform
Authors: Granof Michael , Luby Martin J. , Zachary Matthew 
Published: January 2025

ABSTRACTThe last half‐century has been characterized by ongoing federal deficits as well as recurring government shutdowns, which have only accelerated in the last decade. We contend that Congress has been unable to exercise adequate control over both annual revenues and expenditures not merely due to political partisanship but because of something no less basic: inadequate budgetary and fiscal processes. One budgetary element important to the federal government's fiscal system involves tax expenditures. As a reform to move closer to budgetary balance, we propose in this commentary that Congress should severely scale‐back, recharacterize, and regularly review “tax‐expenditures.”
A Latent Profile Analysis of Relational Maintenance Behaviors in Romantic Relationships
Authors: Pett Rudy C. , Krawietz Colton E. 
Published: January 2025

ABSTRACTExisting research reflects extensive knowledge of how individuals enact relational maintenance (RM) in close relationships and the relational antecedents, as well as outcomes, of RM behaviors. Although traditional approaches often assess the frequencies of five core RM behaviors (e.g., openness, assurances, positivity, social networks, and sharing tasks), little attention has been directed toward how individuals may enact RM behaviors relative to others. The current studies use latent profile analysis (LPA) to examine RM behaviors in romantic relationships. In Study 1 (N = 295), LPA identified two profiles of RM behaviors: below‐average maintainers (n = 78) and above‐average maintainers (n = 217). In Study 2 (N = 1000), LPA identified three profiles of RM behaviors: below‐average maintainers (n = 103), average maintainers (n = 420), and above‐average maintainers (n = 477). Using interdependence theory, profiles were considered in their associations with relational outcomes. Study 1 results demonstrate that relational satisfaction, commitment, and partner facilitation varied by profile membership. Study 2 findings illustrate that relational satisfaction, commitment, partner interference, partner facilitation, and perceived partner commitment varied by profile membership. The results are discussed in terms of their contributions to existing RM research, as well as the use of LPA in this context.
The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces
Authors: Iwatani Yasumasa , Matsuoka Kazuhiro , Ode Hirotaka , Kubota Mai , Nakata Yoshihiro , Setoyama Yuka , Kojima Kanako , Imahashi Mayumi , Yokomaku Yoshiyuki 
Published: January 2025

ABSTRACT

The human cellular cytidine deaminases APOBEC3s (A3s) inhibit virion infectivity factor (Vif)-deficient HIV-1 replication. However, virus-encoded Vifs abolish this defense system by specifically recruiting A3s to an E3 ubiquitin ligase complex to induce their degradation. The highly conserved Vif PPLP motif is critical for the Vif-mediated antagonism of A3s and is believed to be important for Vif multimerization. However, how the PPLP motif dictates the functions of Vif remains unclear. Here, we aimed to elucidate this mechanism using biochemical and structural biology approaches. First, we found that no stable Vif multimer complexes formed in our tandem coimmunoprecipitation assays. Next, a series of Vif truncation mutants were constructed, and the short α-helix α6 just downstream of PPLP was found to be the smallest fragment essential for efficient A3G degradation in cells.
In silico
structural analysis suggested that PPLP-α6 adopts a stable L-shaped conformation when complexed in Vif/CBF-β and contributes to the structural integrity of Vif.
In vitro
ubiquitination assays with recombinant proteins confirmed that PPLP-α6 is necessary to form the functional complex of the E3 ligase adaptor of Vif/CBF-β/elongin B/elongin C. Additionally, mutations of the highly conserved PPLP-α6 hydrophobic residues severely disrupted Vif function. In the Vif structure, PPLP-α6 is positioned behind α1-α2 that constitutes the A3-binding Vif interfaces. Therefore, both the PPLP motif and α6 play critical allosteric roles in maintaining the integrity of the A3 interaction interfaces. Our findings will also provide important data for the design of novel anti-HIV-1 compounds that disrupt the A3-binding Vif interfaces.

IMPORTANCE
The APOBEC3 (A3) family enzymes potently block the replication of retroviruses, such as HIV-1. However, HIV-1 expresses Vif, a small multifaceted protein that binds and specifically eliminates A3s in infected cells via ubiquitination–proteasome degradation. Thus, A3–Vif interactions are attractive targets for anti-HIV-1 drug development. The Vif PPLP motif that is distal from these interfaces is necessary for A3 degradation; however, the mechanism by which PPLP participates in A3 degradation is unknown. In this study, we performed biochemical and structural biology analyses to elucidate the underlying mechanisms involved. We found that the PPLP motif, in addition to the short downstream fragment α6, forms a stable L-shaped conformation and acts as a scaffold for the A3 recognition interfaces. Importantly, mutations in α6 abolished Vif function to antagonize multiple A3 family enzymes. These findings provide important data for the development of novel HIV-1 inhibitors that utilize A3s as cellular defense enzymes.
Small cell carcinoma of the ovary, hypercalcaemic type causing an acute kidney injury
Authors: Baker-Rand Holly , Shawky Mohamed , Agrawal Surabhi , Morrison Jo 
Published: January 2025

SummaryWe report a case of small cell carcinoma of the ovary, hypercalcaemic type, a rare and aggressive form of ovarian cancer, causing an acute kidney injury. A woman in her mid-30s presented with a large pelvic mass and abdominal distention, this was associated with rapidly deteriorating renal function, which did not improve with standardised kidney injury treatment. There was a high suspicion of ovarian cancer. She deteriorated and underwent emergency cytoreductive surgery, followed by systemic chemotherapy. Her presentation, acute kidney injury and electrolyte disturbance preoperatively and postoperatively suggest this was caused by her cancer. Renal dysfunction, due to paraneoplastic syndromes, is a rare oncological emergency seen with solid tumours. Awareness of the condition can lead to early recognition and timely management.
Deep learning-based anterior segment identification and parameter assessment of primary angle closure disease in ultrasound biomicroscopy images
Authors: Li Fangting , Zhang Xiaoyue , Yang Kangyi , Qin Jiayin , Lv Bin , Lv Kun , Ma Yao , Sun Xingzhi , Ni Yuan , Xie Guotong , Wu Huijuan 
Published: January 2025

PurposeTo develop an artificial intelligence algorithm to automatically identify the anterior segment structures and assess multiple parameters of primary angle closure disease (PACD) in ultrasound biomicroscopy (UBM) images.DesignDevelopment and validation of an artificial intelligence algorithm for UBM images.Methods:2339 UBM images from 592 subjects were collected for algorithm development. A multitissue segmentation model based on deep learning was developed for automatic identification of anterior segments and localisation of scleral spur. Then, measurement of the typical angle parameters was performed from the predicted results, including angle-opening distance at 500 µm (AOD 500), trabecular–ciliary angle (TCA) and iris area. We then collected 222 UBM images from 45 subjects in two centres for model validation.ResultsThe multitissue identification model established in this study reached mean Intersection over Union (IoU) of 0.98, 0.98 and 0.98 on cornea segmentation, iris segmentation and ciliary body segmentation and a mean error distance of 1.07 pixels on scleral spur localisation. Our model got a mean IoU of 0.98, 0.98 and 0.99 on cornea segmentation, iris segmentation and ciliary body segmentation and a mean error distance of 0.49 pixels on scleral spur localisation in open-angle images and received 0.98, 0.98, 0.978 and 1.42 pixels respectively in angle-closure images. The mean differences between automatic and manual measurement of the angle parameters were 3.07 μm of AOD, 3.34 degrees of TCA and 0.05 mm2of iris area.ConclusionsThe automatic method of multitissue identification for PACD eyes developed was feasible, and the automatic measurement of angle parameters was reliable.
Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong
Authors: Yan Vincent Ka Chun , Zhang Yin , Yang Deliang , Li Xue , Mak Lung Yi , Lai Francisco T T , Chui Celine S L , Wan Eric Yuk Fai , Wong Carlos , Chan Shirley Chiu Wai , Hung Ivan F N , Lau Chak Sing , Chan Esther Wai Yin , Wong Ian Chi-Kei 
Published: January 2025

IntroductionCOVID-19 infection is associated with post-acute adverse outcomes affecting multiple organ systems. Although preliminary studies have suggested that COVID-19 re-infection may have a cumulative effect on long-term outcome, differential effects of COVID-19 re-infection severe enough to be hospitalised on post-acute sequelae compared with hospitalised first-time infection have not been explored.MethodsRetrospective cohort study using territory-wide electronic medical records databases in Hong Kong. Adults hospitalised with COVID-19 between 1 January and 30 November 2022, who survived the first 28 days after infection and was discharged, were categorised into re-infection and first-time infection groups. Individuals with reinfection were compared with those with first-time infection for all-cause mortality, all-cause hospital readmission, attendance to the emergency department and complications during the post-acute period using propensity-score-weighted Cox regression. Subgroup analyses were conducted by age (<65 and ≥65 years), sex, Charlson Comorbidity Index (0–4, ≥5), COVID-19 vaccination (0–1, 2+doses) and hospitalisation status of previous infection.Results2244 patients with hospitalised COVID-19 re-infection and 58 894 patients with hospitalised first-time COVID-19 infection were included. After a median follow-up of 170 days, re-infection was associated with a significantly higher risk of post-acute all-cause mortality compared with first-time infection (adjusted HR (95% CI): 1.366 (1.166 to 1.600); incidence rate (95% CI): 7.3 (7.1 to 7.5) vs 4.6 (4.4 to 4.7) per 10 000 person-days), all-cause hospital readmission (1.297 (1.200 to 1.403); 50.5 (49.8 to 51.1) vs 28.1 (27.8 to 28.5)), and attendance to emergency departments (1.307 (1.199 to 1.425); 35.4 (34.8 to 35.9) vs 21.9 (21.6 to 22.2)). Findings were consistent across subgroups of age, sex, health status and vaccination status. A greater magnitude of increased risk was observed especially among those hospitalised during a previous infection.ConclusionAmong patients with COVID-19 infection requiring hospitalisation, COVID-19 re-infection was associated with increased post-acute mortality and morbidity compared with first-time infection. Further studies are warranted to delineate the effects on complications.
Study protocol for the development and pilot-testing of a Self-assessment tool for the implementation of the European Standards of Care for Newborn Health (ESCNH)
Authors: Hoffmann Julia , Lehmann Sarah , Ancora Gina , Hummler Helmut , Lack Nicholas , Schlembach Dietmar , Schouten Esther , Simonelli Ilaria , Thernström Blomqvist Ylva , Vavouraki Eleni , Webbe James , Zimmermann Luc J I , Mader Silke , Geiger Isabel 
Published: January 2025

IntroductionIn Europe, disparities exist in having access to optimal neonatal care. With the European Standards of Care for Newborn Health (ESCNH), evidence-based reference standards are available which provide guidance to improve the care for preterm and ill newborns. To support healthcare professionals (HCPs) and hospital/clinic management in identifying the extent of ESCNH implementation, a feasible assessment tool is required. Such a tool should help identify areas in need of improvement and provide clear recommendations for action. We aim to develop a digital self-assessment tool for HCPs to detect the local level of ESCNH fulfilment and identify areas in need of improvement, and thus provide recommendations for action.Methods and analysisThe self-assessment tool will have the form of a digital questionnaire with condensed ESCNH content. A Project Expert Group provides scientific input. With pretesting among HCPs, a template of a questionnaire section is evaluated and adapted accordingly. The subsequently developed full questionnaire will be appraised within a two-round eDelphi survey by at least 50 invited HCPs. Statements and formulations need to be accepted by at least 80% of participants. The remaining discrepancies will be solved in a final workshop. The resulting digital self-assessment tool (SAT) will be translated into several languages and evaluated in a pilot-testing among at least 20 hospitals/clinics across Europe.ConclusionWith the self-reflection through the SAT, HCPs, hospital/clinic managers, policymakers and other stakeholders will receive feedback on the conformity with the ESCNH and guidance for improvement.Trial registration numberNCT06379828.
Protocol for the enhanced management of multimorbid patients with COPD and severe asthma: role of indoor air quality
Authors: Gómez-López Alba , Arismendi Ebymar , Cano Isaac , Farre Ramón , Figols María , Hernández Carme , Montilla-Ibarra Antonio , Sánchez-Ruano Núria , Sánchez Benigno , Sisó-Almirall Antoni , Sorribes Marta , Vela Emili , Piera-Jiménez Jordi , Benavent Jaume , Fermoso Jose , Roca Josep , González-Colom Rubèn 
Published: January 2025

IntroductionReducing unplanned hospital admissions in chronic patients at risk is a key area for action due to the high healthcare and societal burden of the phenomenon. The inconclusive results of preventive strategies in patients with chronic obstructive respiratory disorders and comorbidities are explainable by multifactorial but actionable factors.The current protocol (January 2024–December 2025) relies on the hypothesis that intertwined actions in four dimensions: (1) management change, (2) personalisation of the interventions based on early detection/treatment of acute episodes and enhanced management of comorbidities, (3) mature digital support and (4) comprehensive assessment, can effectively overcome most of the limitations shown by previous preventive strategies. Accordingly, the main objective is to implement a novel integrated care preventive service for enhanced management of these patients, as well as to evaluate its potential for value generation.Methods and analysisAt the end of 2024, the specifics of the novel service will be defined through the articulation of its four main components: (1) enhanced lung function testing through oscillometry, (2) continuous monitoring of indoor air quality as a potential triggering factor, (3) digital support with an adaptive case management (ACM) approach and (4) predictive modelling for early identification and management of exacerbations. During 2025, the novel service will be assessed using a Quintuple Aim approach. Moreover, the Consolidated Framework for Implementation Research will be applied to assess the implementation. The service components will be articulated through four sequential 6-month plan-do-study-act cycles. Each cycle involves a targeted cocreation process following a mixed-methods approach with the active participation of patients, health professionals, managers and digital experts.Ethics and disseminationThe Ethics Committee for Human Research at Hospital Clinic de Barcelona approved the protocol on 29 June 2023 (HCB/2023/0126). Before any procedure, all patients in the study must sign an informed consent form.Trial registration numberNCT06421402.