bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Aplikasi Digital Co-Manufacturing System Pada PT. XYZ Untuk Meningkatkan Kinerja Karyawan
Authors: Anisa Rahmi  , Jauhari Arifin  
Published: December 2022

Seiring berjalannya teknologi, pada kebanyakan perusahaan saat ini diusahakan mampu untuk memanfaatkan teknologi informasi secara baik agar kegiatan bisnis dapat berjalan sesuai renca na agar dapat lebih efektif dan efisien. Pada perkembangan teknologi juga menuntut perusahaan agar terus mengembangkan sistem operasi yang lenih baik dari sebelumnya. Sama halnya dengan kita yang harus tanggap dalam berbagai hal yang berkaitan dengan ilmu dan teknologi untuk membentuk generasi yang memahami berbagai hal tentang perkembangan teknologi. Begitu pula dengan PT. XYZ yang mengembangkan aplikasi yang bernama Digital Co-Manufacturing System (D-COMS) yang diharapkan dapat menyeragamkan laporan lebih dari 20 POTS ke perusahaan sehingga dapat memudah serta mempercepatkan proses pengambilan keputusan. Pada penelitian ini menganalisis bagaimana penerapan system Enterprise Resource Planning (ERP), cara kerja dari aplikasi D-COMS dan proses analisis perancangan aplikasi dimulai dari perancangan kebutuhan, database hingga pengujian. Model yang diterapkan pada penelitian ini yaitu model Waterfall kemudian untuk metode yang diterapkan untuk menganalisis D-COMS ini adalah Black Box Testing, dimana pengujian control struktur yang berasal dari rancangan prosedural guna melakukan tes dan mengetahu internal dari software D-COMS. Berdasarkan hasil analisis, dari segi fungsional, desain web, respond waktu dan segi kelayakan D-COMS sudah memenuhi kelayakan untuk dipergunakan dalam mempercepat kinerja karyawan, dan akan direncanakan dilakuakan pengembangan untuk tahap selanjutnya
Evaluation of risk stratification program based on trajectories of functional capacity in patients with acute coronary syndrome: The REACP study
Authors: Li Dongze , Chen Xiaoli , Li Fanghui , Jia Yu , Li Zhilin , Liu Yi , Ye Lei , Gao Yongli , Zhang Wei , Li Hong , Zeng Rui , Wan Zhi , Zeng Zhi , Cao Yu 
Published: December 2022

BackgroundAs a validated assessment tool for functional disability (activities of daily living), the Barthel index (BI) assessed initially at admission has the potential to stratify patients with high-risk acute coronary syndrome (ACS). Dynamic trajectory evaluation of functional capacity in hospitals may provide more prognostic information. We aimed to establish a novel dynamic BI-based risk stratification program (DBRP) during hospitalization to predict outcomes among ACS patients.MethodsA total of 2,837 ACS patients were included from the Retrospective Multicenter Study for Early Evaluation of Acute Chest Pain. The DBRP rating (low, medium, and high-risk categories) was calculated from dynamic BI at admission and discharge. The primary outcome was all-cause mortality, and the secondary outcome was cardiac mortality.ResultsOf all the included patients, 312 (11%) died during a median follow-up period of 18.0 months. Kaplan–Meier analysis revealed that the cumulative mortality was significantly higher in patients in the higher risk category according to the DBRP. Multivariable Cox regression analysis indicated that, compared to the low-risk category, the higher risk category in the DBRP was an independent strong predictor of all-cause mortality after adjusting for confounding factors (medium-risk category: hazard ratio [HR]: 1.756, 95% confidence interval [95% CI]: 1.214–2.540; P = 0.003; high-risk category: HR: 5.052, 95% CI: 3.744–6.817; P &lt; 0.001), and the same result was found for cardiac mortality.ConclusionThe DBRP was a useful risk stratification tool for the early dynamic assessment of patients with ACS.Clinical trial registration[http://www.chictr.org.cn], identifier [ChiCTR1900024657].
Severe early-onset manifestations of generalized arterial calcification of infancy (mimicking severe coarctation of the aorta) with ABCC6 gene variant — Case report and literature review
Authors: Fãgãrãşan Amalia , Gozar Liliana , Ghiragosian Simina-Elena Rusu , Murariu Mircea , Pop Marian , Crauciuc Andrei , Miclea Diana , Şuteu Carmen Corina 
Published: December 2022

IntroductionGeneralized arterial calcification of infancy (GACI) is a rare cause of infantile heart failure and systemic hypertension with a poor prognosis, characterized by extensive calcification and proliferation of the intimal layer of large and medium sized arteries.Case reportWe present the first case report of successful surgical treatment of severe aortic arch obstruction by calcified plaques mimicking severe coarctation of the aorta and the outcome (of bisphosphonate therapy) in a newborn with GACI. Furthermore, we report the identification of a variant in ATP Binding Cassette Subfamily C, Member 6 (ABCC6) gene, possibly associated with severe early-onset manifestations of GACI.ConclusionThis case report highlights the importance of considering GACI in an infant with heart failure, systemic hypertension, and evidence of increased echogenicity of the arterial vessels. We noted the favorable outcome in improving the aortic calcification in our patient after surgical treatment and bisphosphonates therapy. Early diagnosis and treatment improve the long-term prognosis. A better understanding of this rare genetic disease could lead to new therapeutic strategies.
Loss of perceived social role, an index of social frailty, is an independent predictor of future adverse events in hospitalized patients with heart failure
Authors: Watanabe Ayako , Katano Satoshi , Yano Toshiyuki , Nagaoka Ryohei , Numazawa Ryo , Honma Suguru , Yamano Kotaro , Fujisawa Yusuke , Ohori Katsuhiko , Kouzu Hidemichi , Ishigo Tomoyuki , Katayose Masaki , Hashimoto Akiyoshi , Furuhashi Masato 
Published: December 2022

AimsAlthough the impact of physical frailty on prognosis and the effect of cardiac rehabilitation in HF patients has been well established, data for the prognostic impact of social frailty (SF) in HF patients are limited. In addition, the relative importance of each SF domain in clinical outcomes remains unclear. We aimed to get a new insight into the associations of SF with clinical outcomes in elderly hospitalized HF patients.MethodsA single-center, retrospective cohort study was conducted using data from 310 in-hospital HF patients aged ≥ 65 years (mean age of 78 ± 8 years; 49% women). Makizako’s five questions, a self-reported questionnaire, were used to define SF. The primary outcome was composite events defined by all-cause death and cardiovascular events.ResultsOf the 310 elderly HF patients, 188 patients (61%) had SF. Seventy-five patients (24%) had composite events during a mean follow-up period of 1.93 ± 0.91 years. Kaplan-Meier curves showed that patients with SF had a significantly higher composite event rate than patients without SF. In multivariate Cox regression analyses, SF was independently associated with a higher composite event rate after adjusting for prognostic markers [adjusted hazard ratio (HR), 2.01; 95% confidence interval (CI), 1.07–3.78; p = 0.04]. Of the 5 questions for defining SF, an answer of yes to the question about not feeling helpful toward friends or family, which indicates loss of perceived social role, was an independent predictor of composite events (adjusted HR, 2.28; 95% CI, 1.36–3.82; p &lt; 0.01). Inclusion of loss of perceived social role into the baseline prognostic model improved both the continuous net reclassification improvement (0.562; 95% CI, 0.298–0.827; p &lt; 0.01) and integrated discrimination improvement (0.031; 95% CI, 0.006–0.056; p = 0.02).ConclusionLoss of perceived social role is associated with increased adverse event risk and provides additive prognostic information in elderly HF patients.
Role of aerobic exercise in ameliorating NASH: Insights into the hepatic thyroid hormone signaling and circulating thyroid hormones
Authors: Liu Qiuhong , Li Han , He Weiwei , Zhao Qing , Huang Caoxin , Wang Qingxuan , Zheng Zeyu , Zhang Xiaofang , Shi Xiulin , Li Xuejun 
Published: December 2022

AimTriiodothyronine (T3) administration significantly eliminates hepatic steatosis and also has a therapeutic effect on non-alcoholic steatohepatitis (NASH). However, the potential mechanism by which T3-mediated exercise improves NASH is unknow. This study aimed to explore the effect of aerobic exercise on liver injury in NASH.MethodsAerobic exercise was conducted to explore the effects of exercise on liver injury in NASH model induced by Atherosclerotic (Ath) diet. Biochemical evaluations, histological staining and real-time PCR were first applied to confirm the amelioration effects of exercise on NASH. RNA-sequencing (RNA-seq) analysis for livers of each group were further used to identify the underlying mechanisms of aerobic exercise. Bioinformatics methods were used to explore the key functional pathways involved in the improvement of liver tissue in NASH mice by aerobic exercise.ResultsAerobic exercise improved hepatic steatosis, lobular inflammation and fibrosis in NASH mice. multiple inflammation-related pathways were significantly enriched in the liver of NASH group and improved by aerobic exercise. The results of gene set variation analysis (GSVA) showed a higher enrichment score of T3 response signature in NASH mice with exercise. Increased Dio1 expression in the liver of NASH with exercise mice and increased circulating FT3 and FT4 levels upon aerobic exercise were confirmed.ConclusionsWe found that aerobic exercise could significantly reduce hepatic lipid accumulation, inflammatory infiltration and fibrosis progression in the liver of NASH mice. Hepatic thyroid hormone signaling activation and circulating thyroid hormones is potentially involved in the amelioration effect of aerobatic exercise on NASH progression.
Retroperitoneal laparoscopic partial adrenalectomy (RLPA) for 20-40 mm nonfunctional adrenal tumors in the day surgery mode
Authors: Li Xuwen , Xi Haibo , Yu Yue , Liu Wei , Zhu Xiaoping , Gong Zhixian , Fu Bin , Wang Gongxian , Zhou Xiaochen 
Published: December 2022

ObjectivesTo investigate the outcome and safety of retroperitoneal laparoscopic partial adrenalectomy in the treatment of nonfunctional unilateral adrenal tumors in the day surgery mode.MethodsNineteen patients bearing nonfunctional unilateral 20-40 mm adrenal tumors were prospectively enrolled and underwent retroperitoneal laparoscopic partial adrenalectomy in the day surgery unit of our hospital between June 2021 and March 2022. All patients were diagnosed with non-functional adrenal tumors as outpatients before being admitted to the day surgery unit with their consent. Patient demographics and perioperative data were prospectively documented. The patients were followed up by telephone on day 1, 3 and 7 after discharge and followed up for 6 months.ResultsThe patient’s age was 50.5 ± 11.9 yr (range from 19.0 - 69.0). Seven patients were female. Twelve patients underwent surgery on the left side. The maximal diameter of tumor was 28.3 ± 5.7 mm (20.0 - 40.0 mm). Operation time was 72.1 ± 14.9 min (58.0 - 120.0 min). Mean blood loss was 64.7 ± 50.4 ml (30.0 - 200.0 ml). The gastrointestinal function recovery time was 9.7 ± 2.6 h (6.0 - 16.0 h). Retroperitoneal drainage was removed 24.8 ± 13.3 h (range 18.0 - 72.0) after surgery. Four patients were transferred to the general ward for postoperative management, while others were discharged within 24 hours after surgery. Length of hospital stay was 48.8 ± 13.1 h (38.0 - 85.0h). Hospitalization expense was 24168.4 ± 2910.3 RMB¥ (20844.3 - 34369.8 RMB¥). Postoperative pathology revealed 17 cortical adenoma, 1 pheochromocytoma and 1 lymphatic duct tumor.ConclusionRetroperitoneal laparoscopic partial adrenalectomy for nonfunctional unilateral adrenal tumors in the day surgery mode is safe when strict selection criteria and perioperative management protocol are followed, which has the potential to shorten length of hospital stay and reduce lower hospitalization costs.
Large extent of mercury stable isotope fractionation in contaminated stream sediments induced by changes of mercury binding forms
Authors: Schwab Lorenz , Rothe Florian M. , McLagan David S. , Alten Alexandra , Kraemer Stephan M. , Biester Harald , Wiederhold Jan G. 
Published: December 2022

Mercury (Hg) release from contaminated legacy sites is a large contributor to riverine ecosystems and can represent a significant local and regional environmental issue even long after the initial site contamination. Understanding processes of in-stream species transformation is therefore important to assess the fate and bioavailability of the released Hg. In this study, we investigated in-stream Hg transformation processes with analyses of Hg binding forms and Hg stable isotopes. Stream sediments were collected downstream of a former kyanization facility (Black Forest, SW Germany), where highly soluble Hg(II)-chloride (HgCl2) was used as an anti-fouling agent to treat timber. Exfiltration of partly anoxic, contaminated groundwater with Hg concentrations of up to 700 μg L−1 into the adjacent Gutach stream is the main source of Hg to sediments. Total Hg concentrations in the stream bottom sediments (&lt;2 mm) ranged from background values of 6.3 µg kg−1 upstream of the contaminated site to 77 mg kg−1 near the location of exfiltration of contaminated groundwater. A five-step sequential extraction procedure and Hg pyrolytic thermal desorption (PTD) analyses indicated changes in Hg binding forms in the sediments along the flow path towards a higher proportion of organically bound Hg. A large shift towards negative δ202Hg values was observed downstream of the contaminated site (change of ≈2‰) along with a minor offset in mass-independent fractionation. Binary mixing models based on Hg isotope ratios using one industrial and different natural background endmembers were tested to estimate their respective contribution of Hg to the sediments but failed to produce plausible allocations. Based on the observed changes in isotopic composition, total Hg concentrations and Hg binding forms, we propose that the large extent of fractionation observed in downstream sediments is the result of a combination of kinetic isotope effects during sorption, redistribution of Hg within the sediment and the preferential transport of Hg associated with the sediment fine fraction. These results highlight the importance of transformation processes when assessing the sources and fate of Hg in environmental systems and show limitations of using simple mixing models based on Hg stable isotopes.
Coagulation status and determinants of possible aspirin resistance in patients with essential thrombocythemia
Authors: Yang Erpeng , Lv Yan , Wang Ziqing , Wang Dehao , Li Yumeng , Sun Yan , Zhang Yanyu , Niu Jicong , Chen Zhuo , Liu Weiyi , Hu Xiaomei 
Published: December 2022

ObjectivesThe currently recommended aspirin regimen appears inadequate for thromboprophylaxis in essential thrombocythemia (ET). This study aimed not only to evaluate the curative effect of aspirin but also to explore the coagulation status and determinants of aspirin resistance (AR) of ET patients.MethodsA total of 80 ET patients who underwent coagulation tests, thromboelastography (TEG), and next-generation sequencing (NGS) were involved in the study. Patients were divided into the aspirin sensitivity (AS) group and AR group according to the arachidonic acid inhibition rate. Their clinical features and coagulation function were analyzed.ResultsThe incidence of AR was 53.75% (43/80) in 80 ET patients. Fbg was significantly higher in coagulation tests in AR patients compared with AS patients (P &lt; 0.05), while the differences in other variables (D-D, PT, PTA, INR, APTT, TT, FDP, and AT-III) were not statistically significant (P &gt; 0.05). Compared with AS patients, the K values, α angles, MA values, and CI values of TEG in AR patients were statistically smaller (P &lt; 0.05), but there was no significant difference in R value between them (P &gt; 0.05). Univariate and multivariate logistic regression analysis showed that age, irregular use of aspirin, smoking, dyslipidemia, and hypertension increased the risk of AR (P &lt; 0.05). In the routine NGS, the driver gene and non-driver gene had no effect on AR in ET patients.ConclusionCompared with AS patients, AR patients have enhanced platelet aggregation function, are in a relatively hypercoagulable state, and haveelevated fibrinogen function/levels, all of which cause a worse coagulation status. ET patients with increasing age, irregular use of aspirin, smoking, dyslipidemia, and hypertension are possibly at higher risk of AR. The routine NGS may not be helpful for the prediction of AR, therefore we recommend adding relevant drug-resistance genes to NGS.
EQ-5D full health state after therapy heralds reduced hazard to accrue subsequent organ damage in systemic lupus erythematosus
Authors: Lindblom Julius , Zetterberg Sture , Emamikia Sharzad , Borg Alexander , von Perner Gunilla , Enman Yvonne , Heintz Emelie , Regardt Malin , Grannas David , Gomez Alvaro , Parodis Ioannis 
Published: December 2022

ObjectivesTo investigate whether self-reported EQ-5D full health state (FHS) after therapeutic intervention for active systemic lupus erythematosus (SLE) is associated with a reduced risk to accrue organ damage. In a separate analysis, we sought to investigate associations between experience of “no problems” in each one of the five dimensions of EQ-5D and the risk to accrue damage.MethodsData from the open-label extension periods of the BLISS-52 and BLISS-76 trials of belimumab in SLE (NCT00724867; NCT00712933) were used (N = 973). FHS was defined as an experience of “no problems” in all five EQ-5D dimensions. Organ damage was assessed annually using the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI). Associations between the three-level version of the EQ-5D (EQ-5D-3L) responses at open-label baseline and the first documented increase in organ damage were investigated using Cox regression accounting for age, sex, ancestry, SDI at baseline, and background therapy, and associations with SDI items were investigated using phi (φ) correlation analyses.ResultsA total of 147 patients (15.1%) accrued organ damage during follow-up, with the first increase in their SDI score occurring after a mean time of 29.1 ± 19.6 months. Lower proportions of FHS respondents accrued damage over a course of up to 7.9 years of open-label follow-up compared with no FHS respondents (p = 0.004; derived from the logrank test). FHS was associated with a reduced hazard to accrue subsequent organ damage (HR: 0.60; 95% CI: 0.38–0.96; p = 0.033) after adjustments, as was experience of “no problems” in mobility (HR: 0.61; 95% CI: 0.43–0.87; p = 0.006). “No problems” in mobility was negatively correlated with musculoskeletal damage accrual (φ = −0.08; p = 0.008) and associated with a lower hazard to accrue musculoskeletal damage in Cox regression analysis (HR: 0.38; 95% CI: 0.19–0.76; p = 0.006).ConclusionExperience of EQ-5D-3L FHS and “no problems” in mobility after therapeutic intervention heralded reduced hazard to accrue subsequent organ damage, especially musculoskeletal damage, suggesting that optimisation of these health-related quality of life aspects constitutes a clinically relevant treatment target in patients with SLE, along with clinical and laboratory parameters.
The calibration of esophageal pressure by proper esophageal balloon filling volume: A clinical study
Authors: Jiang Jing , Su Longxiang , Cheng Wei , Wang Chunfu , Rui Xi , Tang Bo , Zhang Hongmin , He Huaiwu , Long Yun 
Published: December 2022

BackgroundEsophageal pressure (Pes) can be used as a reliable surrogate for pleural pressure, especially in critically ill patients requiring personalized mechanical ventilation strategies. How to choose the proper esophageal balloon filling volume and then find the optimal value of esophageal pressure remains a challenge. The study aimed to assess the feasibility of catheters for Pes monitoring in mechanically ventilated patients.Materials and methodsTwelve patients under pressure-controlled mechanical ventilation were included in this study. Raw esophageal pressure was recorded at different balloon filling volumes. Then, the P-V curves were determined. VWORK was the intermediate linear section on the end-expiratory P-V curve, and VBEST was the filling volume providing the maximum difference between Pes at end-inspiration and end-expiration. The raw value of Pes was recorded, and the calibrated values of Pes were calculated by calculating the esophageal wall pressure (Pew) and esophageal elastance (Ees).ResultsTwenty-four series of Pes measurements were performed. The mean VMIN and VMAX were 2.17 ± 0.49 ml (range, 1.0–3.0 ml) and 6.79 ± 0.83 ml (range, 5.0–9.0 ml), respectively, whereas VBEST was 4.69 ± 0.16 ml (range, 2.0–8.0 ml). Ees was 1.35 ± 0.51 cm H2O/ml (range, 0.26–2.38 cm H2O/ml). The estimated Pew at VBEST was 3.16 ± 2.19 cm H2O (range, 0–7.97 cm H2O). Patients with a body mass index (BMI) ≥ 25 kg/m2 had a significantly lower VMAX (5.88 [5.25–6] vs. 7.25 [7–8] ml, p = 0.006) and a significantly lower VBEST (3.69 [2.5–4.38] vs. 5.19 [4–6] ml, p = 0.036) than patients with a BMI &lt; 25 kg/m2. Patients with positive end-expiratory pressure (PEEP) ≥ 10 cm H2O had a lower VMIN and VBEST than patients with PEEP &lt; 10 cm H2O, P &gt; 0.05. Patients in the supine position had a higher esophageal pressure than those in the prone position with the same balloon filling volume.ConclusionsCalibration of esophageal pressure to identify the best filling volume of esophageal balloon catheters is feasible. The esophageal pressure can be influenced by BMI, PEEP, and position. It is necessary to titrate the optimal inflation volume again when the PEEP values or the positions change.
Endoscopic surgery for spontaneous supratentorial intracerebral haemorrhage: A systematic review and meta-analysis
Authors: Hallenberger Tim J. , Guzman Raphael , Bonati Leo H. , Greuter Ladina , Soleman Jehuda 
Published: December 2022

IntroductionTreatment for spontaneous supratentorial intracerebral haemorrhage (SSICH) is limited and consist of either best medical treatment (BMT) or surgical hematoma evacuation. Treatment methods and choice of surgical technique are debated, and so far, no clear advantage of endoscopic surgery (ES) over conventional craniotomy (CC) or BMT was shown. The aim of this systematic review and meta-analysis was to investigate the differences in outcome, morbidity, and mortality between ES and CC or BMT.MethodsWe systematically searched Embase and PubMed databases for randomised controlled trials comparing ES to CC or BMT. The primary outcome was favourable functional outcome after 6 months. Secondary outcomes were morbidity and mortality rates and duration of surgery.ResultsSeven articles were eligible for the outcome analysis with 312 subjects in the control (216 CC, 96 BMT) and 279 in the treatment group (ES). Compared to BMT, ES showed significantly improved favourable functional outcome (RR 1.93 [1.12; 3.33], p = 0.02) and mortality rates (RR 0.63 [0.44; 0.90], p = 0.01). No significant difference in favourable functional outcome and mortality was seen in ES compared to CC (RR 2.13 [0.01; 737], p = 0.35; RR 0.42 [0.17; 1.05], p = 0.06). ES showed significantly lower morbidity (RR 0.41 [0.29; 0.58], p &lt; 0.01), and overall infection rates (RR 0.33 [0.20; 0.54], p &lt; 0.01) compared to CC. Duration of surgery was significantly shorter for ES compared to CC (SMD −3.17 [−4.35; −2.00], p &lt; 0.01).ConclusionES showed significantly improved favourable functional outcome and mortality rates compared to BMT while showing reduced length of surgery and lower complication rates compared to CC. Therefore, ES appears a promising approach for treatment of SSICH justifying further prospective trials.Systematic review registrationPROSPERO, identifier: CRD42020181018.