bluuebunny/crossref_metadata_2025_split huggingface dataset:
RANCANG BANGUN ALAT PERAJANG UBI KAYU DENGAN TRANSMISI PULI DAN SABUK PADA PUTARAN MOTOR LISTRIK 1400 RPM DAN DAYA MOTOR 0,5 HP
Authors: Anwar Irwan , Afdal Afdal , Wardianto Dedi 
Published: January 2025

Ubi kayu merupakan salah satu komoditi pangan yang berkembang saat ini, para pelaku home industry pun berlomba untuk menghasilkan makanan berbahan dasar ubi yang beragam. Dalam proses pengelolaan nya masyarakat masih banyak menggunakan cara tradisional. Proses kerja dengan cara tradisional kurang memberikan hasil yang memuaskan karena produktifitasnya rendah, oleh karena itu penulis mencoba mengembangkan suatu alat perajang ubi yang mampu menghasilkan produktifitas yang efektif dan efisien. Alat perajang ubi kayu dengan transmisi puli dan sabuk pada putaran motor listrik 1400 rpm dan daya motor 0,5 hp, mampu menghasil kan kapasitas pemotongan hingga 66 kg/jam. Alat perajang ubi ini mempunyai 2 mata pisau yang di baut pada piringan rumah mata pisau, dengan kecepatan sudut piringan 73 rad/s dan gaya yang di hasil kan oleh piringan sebesar 24,56 N. Putaran puli penggerak sebesar 700 rpm dengan perbandingan reduksi 2. Bahan puli yang di gunakan adalah FC30 dan tipe sabuk yang di gunakan adalah Tipe sabuk A, dengan diameter poros penggerak 12 mm dan poros yang di gerak kan 15 mm. Bearing yang di gunakan adalah bearing 6202. Alat perajang ubi ini mempunyai landasan potong dengan sisitem pegas tekan, yang dapat meminimalisir tingkat kecelakaan kerja.
PEMANFAATAN SERAT BAMBU SEBAGAI BAHAN TAMBAH CAMPURAN BETON
Authors: Mulyati Mulyati , Arman Arman , Aulia Farhan Muhammad , Alawiyah Nurfelia 
Published: January 2025

Bambu merupakan tanaman penghasil serat yang dapat digunakan sebagai alternatif bahan tambah serat untuk campuran beton untuk mengatasi retak pada beton. Tujuan dari penelitian ini adalah untuk mengetahui nilai kuat tekan dan kuat tarik belah beton dari penggunaan serat bambu sebagai bahan tambah campuran beton. Bambu yang digunakan adalah bambu petung dan bambu apus, ukuran serat panjang 20 mm dan diameter 1-2 mm, dengan persentase 1%, 2%, 3%, 4%, 5% dari berat semen. Perencanaan campuran beton menggunakan SNI 7656-2012 untuk kuat tekan rencana 20 MPa pada umur 28 hari. Hasil pengujian kuat tekan dan kuat tarik belah beton dari persentase penggunaan serta, untuk bambu petung diperoleh kuat tekan beton rata-rata berturut-turut sebesar 23,58 MPa, 24,69 MPa, 19,45 MPa, 17,17 MPa, 13,02 MPa, dan kuat tarik belah beton berturut-turut sebesar 2,05 MPa, 2,40 MPa, 2,06 MPa, 2,03 MPa, 2,02 MPa, sedangkan untuk bambu apus diperoleh kuat tekan beton rata-rata berturut-turut sebesar 22,56 MPa, 23,07 MPa, 15,37 MPa, 14,09 MPa, 14,07 MPa, dan kuat tarik belah beton rata-rata berturut-turut sebesar 2,15 MPa, 2,50 MPa, 2,47 MPa, 2,40 MPa, 2,30 MPa. Penggunaan serat bambu sampai 2% pada campuran beton dapat meningkatkan kuat tekan beton, dan penggunaan serat bambu sampai 5% dapat meningkatkan kuat tarik belah beton. Serat bambu petung menghasilkan kuat tekan beton yang lebih tinggi dari pada serat bambu apus, sedangkan serat bambu apus menghasilkan kuat tarik belah beton yang lebih tinggi dari pada serat bambu petung.
Implementing Symptom-Based Predictive Models for Early Diagnosis of Pediatric Respiratory Viral Infections
Authors: Soriano-Arandes Antoni , Andrés Cristina , Perramon-Malavez Aida , Creus-Costa Anna , Gatell Anna , Martín-Martín Ramona , Solà-Segura Elisabet , Riera-Bosch Maria Teresa , Fernández Eduard , Biosca Mireia , Capdevila Ramon , Sánchez Almudena , Soler Isabel , Chiné Maria , Sanz Lidia , Quezada Gabriela , Pérez Sandra , Canadell Dolors , Salvadó Olga , Ridao Marisa , Sau Imma , Rifà Mª Àngels , Macià Esperança , Burgaya-Subirana Sílvia , Vila Mònica , Vila Jorgina , Mejias Asunción , Anton Andrés , Soler-Palacin Pere , Prats Clara 
Published: January 2025

Abstract

Introduction: Respiratory viral infections, including SARS-CoV-2, respiratory syncytial virus (RSV), influenza, rhinovirus, and adenovirus, are major causes of acute respiratory illness (ARI) in children. Symptom-based predictive models are valuable tools for expediting diagnoses, particularly in primary care settings. This study assessed the effectiveness of machine learning-based models in estimating infection probabilities for these common pediatric respiratory viruses using symptom data.
Methods: Data were collected from 868 children with ARI symptoms evaluated across 14 primary care centers, members of COPEDICAT (Coronavirus Pediatria Catalunya), from October 2021 to October 2023. Random Forest and Boosting models with 10-fold cross-validation were used, applying SMOTE-NC to address class imbalance. Model performance was evaluated via area under the curve (AUC), sensitivity, specificity, and Shapley Additive exPlanations (SHAP) values for feature importance.
Results: The model performed best for RSV (AUC: 0.81, sensitivity: 0.64, specificity: 0.77) and effectively ruled out SARS-CoV-2 based on symptom absence, such as crackles and wheezing. Predictive performance was lower for non-enveloped viruses like rhinovirus and adenovirus, due to their nonspecific symptom profiles. SHAP analysis identified key symptoms patterns for each virus.
Conclusions: The study demonstrated that symptom-based predictive models effectively identify pediatric respiratory infections, with notable accuracy for RSV, SARS-CoV-2 and influenza.
Elevating RNA m5C methylation provides a promising strategy for crop productivity
Authors: Gu Xiaofeng , Li Xiulan , Li Cong , Wang Xiangyu , Yang Liwen , Guo Weijun , Mao Yichao , Liu Hanlin , Li Dongwei , Yan Shuangyong 
Published: January 2025

Abstract

RNA 5-methylcytidine (m5C) has been identified as a key epi-transcriptomic modification of mRNAs involved in regulating multiple post-transcriptional processes. Here, we found that knockout of the RNA m5C demethylase, OsNOP2, results in elevated m5C levels and positively influences numerous agronomic traits in rice. After verifying OsNOP2 RNA m5C demethylase function in vitro and in planta, we found that enhanced m5C levels arising from OsNOP2 knockout results in increased translation, particularly for transcripts involved in carbon assimilation and nitrogen metabolism. OsNOP2-KO boosts grain yield ~28% per plot in the Nipponbare genetic background in normal condition and maintains increased yield traits under both heat treatment and saline soil conditions. More importantly, knockout of OsNOP2 in the rice varieties Longgeng31 and Xiushui134, as well as its orthologs in wheat and tomato, also increases the RNA m5C level to enhance yield, supporting functional conservation of OsNOP2's regulatory impacts. Together, our findings unveil an RNA m5C elevating mechanism by OsNOP2 that epigenetically governs carbon assimilation and nitrogen utilization efficiency in plant, providing a potential strategy for genetic improvement in multiple crops.
Career Adaptability and Its Relation to Thriving at Work among Staff Nurses
Authors: Badran Fawzia M. , Mohamed Eman H. 
Published: January 2025

Abstract

Background
Career adaptability is vital in the nursing profession, especially given the rapidly changing healthcare environment. This adaptability nurtures a workplace where nurses can thrive excel, continuously develop new skills, and stay fully engaged in their roles.
Aim
The present research aimed to assess career adaptability and its relation to thriving at work among staff nurses.
Methods
A descriptive correlational design was included 105 staff nurses.
Results
In this research, the studied subjects reported that more than one fifth (21%) of studied nurses had a low level regarding total career adaptability. Also, more than half (55.2%) of them had moderate level regarding total career adaptability. While, (23.8%) of them had high level regarding total career adaptability. Furthermore, the minority (16.2%) of staff nurses had a low level regarding total thriving at work. Also, (65.7%) of them had moderate level regarding total thriving at work. While, only (18.1%) of them had high level regarding total thriving at work.
Conclusion
This research was concluded that career adaptability was positively correlated and significantly with thriving at work among nurses (r = .194**, p = 0.000).
Recommendation: The healthcare organizations should implement targeted interventions such as personalized career development programs, wellness initiatives to boost energy levels, and enhanced access to continuous learning opportunities.
Trial Registration Number [TRN] The study protocol was approved by the Research Ethics Committee of the Faculty of Nursing, Ain Shams University[code number: NUR 24.8.345].
An Updated Review of the SMA Clinical Trial Landscape in the United States: Findings from Analysis of Recruitment Targets on ClinicalTrials.gov and a Survey of SMA Clinical Trial Sites on Factors Affecting Site Capacity and Readiness
Authors: Sarr Fatou , Peterson Ilse , Glascock Jacqueline , Schroth Mary , Curry Mary 
Published: January 2025

Abstract

The approval of new disease-modifying treatments, diagnostic tools, and expansion of the drug pipeline has evolved clinical trial landscape for spinal muscular atrophy (SMA) - a rare neuromuscular disease. Nonetheless, significant unmet needs for the SMA population remain and requires continued evolution of the SMA clinical trial landscape. In 2023, Cure SMA developed a series of activities to asses the current SMA clinical trial landscape including the Cure SMA Capacity and Recruitment Survey. The purpose of the survey is to understand site capacity for SMA clinical trials in the US, identify factors that may limit site trial capacity and or readiness, and identify opportunities to increase site capacity. Twenty-four sites across the US with experience in conducting SMA clinical trials are represented in the results. Although existing clinical trial sites may have the capacity to take on additional SMA trials, many factors are inhibiting efficient trial management and study start-up. As recruitment needs for SMA clinical trials continue to evolve, action is needed to address the site needs – such as increased clinical staff support and bandwidth, streamlining training, and adequate funding to conduct trials - to further optimize trial site readiness and capacity. SMA clinical trial sites, sponsors, and contract research organizations will need to work together to optimize trial site readiness address challenges to capacity.
Development and validation of a nomogram for predicting necrotizing pneumonia in children with refractory Mycoplasma pneumoniae pneumonia
Authors: zhao lihua , Li Xiaoying , Cui Xiaojian , Xu Yongsheng , Zhang Tongqiang , Guo Wei , Ning Jing 
Published: January 2025

Abstract

Background
The early prediction of pulmonary necrosis in children with severe pneumonia improves patient prognosis and prevents complications. The aim of this study was to establish a linear model for predicting necrotizing pneumonia (NP) caused by Mycoplasma pneumoniae (MP) infection and to investigate the risk factors for lung necrosis in children with refractory Mycoplasma pneumoniae pneumonia (RMPP).
Methods
A total of 536 children with RMPP were enrolled, including 95 with NP and 441 with nonnecrotizing pneumonia (NNP). A prediction model was built on 375 cases and validated on 161 cases, which were divided by random sampling in R software. Multivariate logistic regression was performed to determine optimal predictors and to establish a nomogram for predicting NP. The performance of the nomogram was evaluated by the area under the characteristic curve (AUC), calibration ability and decision curve analysis (DCA).
Results
There were 315 (84.0%) NNP patients and 60 (16.0%) NP patients in the training group (n = 375) and 126 (78.3%) NNP patients and 35 NP patients (21.7%) in the validation group (n = 161). Multivariate logistic regression analysis identified 4 independent predictors that were used to construct a nomogram for predicting NP in children with RMPP, namely, fever duration (OR = 1.475; 95% CI 1.296–1.678; P < 0.001), WBC count (OR = 1.149; 95% CI 1.073–1.231; P < 0.001), IL-6 concentration (OR = 1.007; 95% CI 1.002–1.013; P = 0.007) and D-dimer concentration (OR = 1.361; 95% CI 1.121–1.652; P = 0.002). The area under the curve (AUC) of the nomogram was 0.899 (95% CI, 0.850–0.947) in the training set and 0.920 (95% CI, 0.874–0.966) in the validation set, indicating a good fit. The calibration plot and Hosmer‒Lemeshow test indicated that the predicted probability had good consistency with the actual probability in the training (P = 0.439) and validation (P = 0.526) groups. The DCA curve demonstrated a significantly better net fit in the model.
Conclusions
We developed and validated a nomogram model for predicting RMPP-associated NP in its early clinical stages using four risk factors. This four-risk factor model may assist physicians in predicting NP induced by RMPP.
Brucella abortushijacks the host protein Slc2a1via the SepA effector to promote intracellular survival in macrophages
Authors: Yang Yuanhao , Zu Yaping , Wang Xin , Wang Hui , Liu Xiaofang , Tang Ting , Zhai Yunyi , Wudong Gaowa , Wang Pingping , Yuan Ningqiu , Zhou Dong , Jin Yaping , Wang Aihua 
Published: January 2025

Abstract

Brucella spp. are facultative intracellular bacteria that infect and induce brucellosis in a diverse range of mammalian hosts. The disease causes major global economic losses and also is a worldwide threat to public health security. Characterization of bacterial and host factors that promote intracellular survival of Brucella is key for the prevention and control of brucellosis. In this study, we identified proteins involved in intracellular survival of Brucella abortus A19 in RAW264.7 macrophage cells by liquid chromatography-mass spectrometry of macrophages with or without B. abortus infection. The functions of these proteins, the signaling pathways in which the proteins participate, the domain entries enriched by the proteins, and the subcellular localization of the differentially-expressed proteins were deciphered. Differential protein expression revealed that Slc2a1, which is a key Glycolytic protein, was significantly upregulated in infected macrophage cells. This observation was confirmed by qRT-PCR and Western blotting studies. The role of Slc2a1 in the intracellular survival of B. abortus was probed by overexpressing and knocking down SLC2A1 in RAW264.7 cells. Overproduction of the protein promoted intracellular proliferation of B. abortus whereas knockdown of SLC2A1 inhibited proliferation of the bacterium. Finally, we determined that the Secreted Effector Protein A (SepA) effector of B. abortus enhanced SLC2A1 expression in macrophage cells. Thus, B. abortus stimulates host SLC2A1 expression via the SepA effector protein to aid bacterial survival in the macrophage environment which suggests that SepA may be a novel antibacterial target to combat Brucella infection.
Nomogram for Predicting Lymph Node Metastasis in Cervical Cancer: Comparison of 2009 and 2018 Staging Systems
Authors: Li Suyu , Chen Yusha , Chen Xiaoying , Li Xiaoyan , Zhou Guangrun , Huang Liyuan , Huang Qiuyuan , Huang Xizhen , Huang Zhijian , Liu Zhaodong , Zheng Xiangqin 
Published: January 2025

Abstract

OBJECTIVES
Lymph node metastasis (LNM) is crucial for personalized
treatment in cervical cancer (CC) patients; this study evaluates
the enhancement of LNM prediction models by integrating the 2018
FIGO staging system into those based on the 2009 FIGO cohort and
assesses the models' net benefit.

METHORDS: We included 691 patients: 348 with 2009 FIGO stage IB1-IIA2 CC (Cohort 1) for model development and external validation, and 343 with 2018 FIGO stage IB1-IIICr CC (Cohort 2) for external validation. Variables were selected using regression analyses and LASSO methods. Nomogram models were evaluated with ROC curves, C-index, Integrated Discrimination Improvement (IDI), and Net Reclassification Index (NRI). RESULTS: Model 1 included tumor size, depth of stromal invasion (DSI), SCC-Ag, and neutrophil-to-lymphocyte ratio (NLR). Model 2 incorporated the FIGO staging system. Model 1 showed suitable calibration with discrimination accuracy of 0.807 in the training cohort and 0.772 in the testing cohort. External validation yielded an AUC of 0.743. Model 2, with the 2018 FIGO image staging, demonstrated superior performance for predicting LNM, with a discrimination accuracy of 0.877, significant ΔC-index (P = 0.0024). Adding the 2009 FIGO clinical staging did not significantly enhance predictive value (ΔC-index P = 0.896). Model 2's predictive performance improved by 23.18% in the low-to-intermediate risk group and 17.24% in the high-risk group. CONCLUDSION: Incorporating the 2018 FIGO image staging system into the 2009 FIGO clinical staging model significantly improved LNM prediction, highlighting the importance of imaging-based staging systems and facilitating their application across different time periods.
Impact of Various Qigong and Tai Chi Exercises on Motor Function, Depression, and Quality of Life in Parkinson's Disease Patients: A Network Meta-Analysis
Authors: Zhao Jiankang , Yang Ming , Li Ziye , Lu Jun , Kong Yafei , Tian Zhuyun , Zhang Changrun 
Published: January 2025

Abstract

Fitness Qigong and Tai Chi, as forms of exercise therapy, are suitable for Parkinson's disease (PD) patients who are mainly middle-aged and elderly, and their effectiveness has been proven by an increasing number of studies. However, there is a serious issue in some previous studies, which is the misconception of considering Fitness Qigong and Tai Chi as a specific form of exercise. In fact, Fitness Qigong and Tai Chi are not single forms of exercise, but rather a general term for a category of exercises. Since the fitness effects of different types of Fitness Qigong and Tai Chi are not exactly the same, it is necessary to conduct a more specific classification of Fitness Qigong and Tai Chi and then perform a network Meta-analysis to explore the effects of different types of Fitness Qigong and Tai Chi on treating different symptoms of PD. By comprehensively collecting and organizing literature from English and Chinese databases such as Pubmed, Embase, Cochrane Library, Web of Science, CNKI, and Wan Fang, with the literature search cut-off date being November 22, 2024, and extracting data from the finally included randomized controlled trials. According to the Cochrane Risk of Bias Assessment Tool in the Cochrane Handbook, the methodological quality and bias risk of the included literature were evaluated using RevMan 5.4 software, and finally, Stata 18.0 software was used for network Meta-analysis. During the analysis, subgroup analyses were conducted based on different intervention types, intervention periods, Hoehn-Yahr stages, and patient disease courses to explore the sources of heterogeneity. The 35 studies included in this article involved 4 types of Fitness Qigong exercises and 4 types of Tai Chi exercises, with a total of 1,763 patients with mild to moderate Parkinson's disease. The results of the network Meta-analysis showed that compared with the conventional treatment of Parkinson's disease, 24-Form Tai Chi Qigong (24-FTJQ) was the best treatment plan for improving UPDRS Ⅲ scores and Berg Balance Scale (BBS) scores; 42-Form Tai Chi Qigong (ATJQ) was the best treatment plan for improving Gait Velocity; Wu Qin Xi (WQX) was the best treatment plan for improving Timed Up and Go Test (TUGT) scores; Ba Duan Jin (BDJ) was the best treatment plan for improving Depression scores; and Yi Jin Jing (YJJ) was the best treatment plan for improving PDQ-39 scores. Therefore, in clinical practice, more suitable exercise plans can be formulated according to the main symptoms of patients, reducing the treatment period.
An Implementation Of Patient Blood Management Program In Total Hip and Total Knee Replacement Patients
Authors: Kougioumtzis Ioannis , Chatzipapas Christos , Tzatzairis Themistoklis , Tottas Stylianos , Iliopoulos Efthymios , Tilkeridis Konstantinos , Ververidis Athanasios 
Published: January 2025

Abstract

Introduction
The implementation of patients’ blood management (PBM) is being leaded in a considerable decline of both blood loss and allogenic blood transfusion in primary Total Hip (THR) and Knee Replacement (TKR). The aim was to outline the results after a stepwise implementation of PBM protocol in THR and TKR.
Material and Methods
We conducted a retrospective study. A PBM protocol regarding the entire blood bleeding, the use of tranexamic acid (TXA) (0gr or 1gr or 2gr), the preoperative anaemia and a transfusion trigger (from 10 to 8 Hb gr/dl) was applied. Patients and surgery related data were prospectively recorded and analyzed.
Results
427 patients underwent either TKR (n:260) or THR (n:167). In both TKR and THR presented gradual reduction (a) blood loss from 1.430 to 1.129 and from 1.277 to 1.101 respectively, (b) transfusion rate from 30.4–0.2% and from 35.7–0.1% respectively and (c) mean hospitalization from 5 to 2.97 days and from 4.8 to 2.87 days respectively. In TKR, pre-operative anaemia was an independent determinant of bleeding, as were BMI > 30, ASA > II and no-TXA use. Independent determinants of transfusion rate were pre-operative anemia and no-TXA use. In THR, independent determinants of hemorrhage were male, BMI > 30, operation > 90 minutes, transfusion rate, pre-operative anaemia and no-TXA use.
Conclusion
The implementation of a restrictive PBM protocol addressing the “modifiable” factors of increased blood loss and transfusion rate such as pre-operative anemia, TXA use, short surgical time and low transfusion trigger can substantially reduce the transfusion of allogenic blood.
Level of Evidence
II
Oral antibiotics combined with mechanical bowel preparation reduces the risk of surgical site infections in minimally invasive colorectal cancer surgery
Authors: Park Eun Ji , Park Min Young , Han Yoon Dae , Cho Min Soo , Hur Hyuk , Min Byung Soh , Lee Kang Young , Yang Seung Yoon 
Published: January 2025

Abstract

Purpose
Colorectal surgeries are associated with high rates of surgical site infection (SSI), which significantly impact postoperative recovery and outcomes. Use of preventive measures, such as mechanical bowel preparation (MBP) and preoperative oral antibiotics (POA), is widely debated. This study investigated the effectiveness of POA plus MBP before elective minimally invasive colorectal cancer surgery.
Methods
This study retrospectively analyzed 1,506 patients who underwent elective minimally invasive colorectal cancer surgery between January 2020 and December 2023 to evaluate the effectiveness of MBP plus POA in preventing SSIs and other postoperative complications. Patients were divided into MBP alone (n = 811) and POA + MBP (n = 695) groups.
Results
Overall SSI rates were significantly lower in the POA + MBP group than in the MBP alone group (11.6% vs. 5.5%, p = 0.008), with significant reductions in grade 1–2 SSIs. POA + MBP was particularly effective in patients undergoing colon cancer surgery. In this subgroup, POA + MBP was associated with a 5.6% lower rate of SSIs than MBP alone, with no difference in anastomosis leakage rates between regimens. In patients undergoing rectal cancer surgery, POA + MBP was associated with a significantly higher anastomosis leakage rate (6.9% vs. 2.2%, p = 0.016), with no difference in SSI rates between regimens. Multivariable analysis confirmed that MBP alone was a risk factor for SSIs (odds ratio, 1.5; 95% confidence interval, 1.13–2.18; p = 0.007).
Conclusion
This study highlights the differential effects of POA + MBP in minimally invasive surgery for colon versus rectal cancer and underscores the need for further investigations to determine the optimal bowel preparation regimen for specific surgical sites.