bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome
Authors: Dueñas Nuria , Klinkhammer Hannah , Bonifaci Nuria , Spier Isabel , Mayr Andreas , Hassanin Emadeldin , Diez-Villanueva Anna , Moreno Victor , Pineda Marta , Maj Carlo , Capellà Gabriel , Aretz Stefan , Brunet Joan 
Published: June 2023

BackgroundPolygenic risk scores (PRSs) have been used to stratify colorectal cancer (CRC) risk in the general population, whereas its role in Lynch syndrome (LS), the most common type of hereditary CRC, is still conflicting. We aimed to assess the ability of PRS to refine CRC risk prediction in European-descendant individuals with LS.Methods1465 individuals with LS (557MLH1, 517MSH2/EPCAM, 299MSH6and 92PMS2) and 5656 CRC-free population-based controls from two independent cohorts were included. A 91-SNP PRS was applied. A Cox proportional hazard regression model with ‘family’ as a random effect and a logistic regression analysis, followed by a meta-analysis combining both cohorts were conducted.ResultsOverall, we did not observe a statistically significant association between PRS and CRC risk in the entire cohort. Nevertheless, PRS was significantly associated with a slightly increased risk of CRC or advanced adenoma (AA), in those with CRC diagnosed <50 years and in individuals with multiple CRCs or AAs diagnosed <60 years.ConclusionThe PRS may slightly influence CRC risk in individuals with LS in particular in more extreme phenotypes such as early-onset disease. However, the study design and recruitment strategy strongly influence the results of PRS studies. A separate analysis by genes and its combination with other genetic and non-genetic risk factors will help refine its role as a risk modifier in LS.
Clinical feature and disease outcome in patients with myelin oligodendrocyte glycoprotein antibody-associated disorder: a Chinese study
Authors: ZhangBao Jingzi , Huang Wenjuan , Zhou Lei , Tan Hongmei , Wang Liang , Wang Min , Yu Jian , Lu Chuanzhen , Lu Jiahong , Quan Chao 
Published: June 2023

BackgroundTo identify factors associated with relapse risk and disability in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD).MethodBetween 2016 and 2021, 186 patients with MOGAD were included in the study. Factors associated with a relapsing course, annualised relapse rate (ARR), recurrent relapses under different maintenance treatments and unfavourable disability outcome were analysed.ResultsMOGAD affects women (53.8%) slightly more often than men. After a median disease duration of 51.0 months, 60.2% (112/186) relapsed, with an overall ARR of 0.5. The ARR (0.6 vs 0.4, p=0.049), median Expanded Disability Status Scale (EDSS) score (1 (range 0–9.5) vs 1 (range 0–3.5), p=0.005) and Visual Functional System Score (VFSS) (0 (range 0–6) vs 0 (range 0–3), p=0.023) at last visit were higher in adults than in children, and time to first relapse was shorter in adults than in children (4.1 (range 1.0–111.0) vs 12.2 (range 1.3–266.8) months, p=0.001). Myelin oligodendrocyte glycoprotein antibody (MOG-ab) persistence over 1 year was associated with a relapsing course (OR 7.41, 95% CI 2.46 to 22.33, p=0.000), while timely maintenance therapy was associated with a lower ARR (p=0.008). More than four attacks (OR 4.86, 95% CI 1.65 to 14.28, p=0.004) and poor recovery from the first attack (OR 75.28, 95% CI 14.45 to 392.05, p=0.000) were associated with an unfavourable outcome (EDSS score ≥2 including VFSS ≥2).ConclusionsThe results underscored the importance of timely maintenance treatment to prevent further relapses, especially in adult patients with persistently positive MOG-ab and unsatisfactory recovery from the onset attack.
Skeletal muscle fibre morphology in childhood—insights into myopenia in pediatric liver disease
Authors: Hager Amber , Mazurak Vera , Noga Michelle , Gilmour Susan M. , Mager Diana R. 
Published: June 2023

Myopenia (reduced skeletal muscle [SM]) is common in children with end-stage liver disease (ESLD) and suboptimal nutritional status pre- and post-liver transplantation (LTx). Myopenia may result in altered SM morphology (changes in muscle fibre size and types [type I vs. II proportions]) contributing to adverse outcomes and deficits in muscle strength/functionality. Understanding how SM morphology changes in healthy children with age and the potential impact of ESLD on SM morphology offers insight into the effectiveness of rehabilitation strategies for children with ESLD at risk for myopenia. Literature searches in PubMed, Scopus, and Web of Science identified studies examining SM morphology in healthy children and in ESLD. Muscle fibre size increases with age in healthy children. Type I fibres are more prevalent in childhood, whereas type II fibres increase post-puberty. Preliminary evidence indicates that adults with ESLD have reduced muscle fiber size with type II fibre atrophy. No data are available for pediatric ESLD. SM morphology changes with age and may be impacted by the negative physical and metabolic insults associated with ESLD and malnutrition. Take-home message Skeletal muscle morphology in healthy children changes with age. Liver disease may preferentially affect type II fibres in adults with end-stage liver disease (ESLD). More research is needed on the effects of ESLD on muscle morphology in children.
Transactional Services for Concurrent Mobile Agents over Edge/Cloud Computing-Assisted Social Internet of Things
Authors: Al-Qerem Ahmad , Ali Ali Mohd , Nashwan Shadi , Alauthman Mohammad , Hamarsheh Ala , Nabot Ahmad , Jibreen Issam 
Published: June 2023

The Web of Things (WoT) is a concept that aims to create a network of intelligent devices capable of remote monitoring, service provisioning, and control. Virtual and Physical Internet of Things (IoT) gateways facilitate communication, processing, and storage among social nodes that form the social Web of Things (SWoT). Peripheral IoT services commonly use device data. However, due to the limited bandwidth and processing power of edge devices in the IoT, they must dynamically alter the quality of service provided to their connected clients to meet each user's needs while also meeting the service quality requirements of other devices that may access the same data. Consequently, deciding which transactions get access to which Internet of Things data is a scheduling problem.
Edge-cloud computing requires transaction management because several Internet of Things transactions may access shared data simultaneously. However, cloud transaction management methods cannot be employed in edge-cloud computing settings. Transaction management models must be consistent and consider ACIDity of transactions, especially consistency. This study compares three implementation strategies, Edge Host Strategy (EHS), Cloud Host Strategy (CHS), and Hybrid BHS (BHS), which execute all IoT transactions on the Edge host, the cloud, and both hosts, respectively. These transactions affect the Edge hosts as well. An IoTT framework is provided, viewing an Internet of Things transaction as a collection of fundamental and additional subtransactions that loosen atomicity. Execution strategy controls essential and additional subtransactions.
The integration of edge and cloud computing demonstrates that the execution approach significantly affects system performance. EHS and CHS can waste wireless bandwidth, while BHS outperforms CHS and EHS in many scenarios. These solutions enable edge transactions to complete without restarting due to outdated IoT data or other edge or cloud transactions. The properties of these approaches have been detailed, showing that they often outperform concurrent protocols and can improve edge-cloud computing.
Abstract 114: Postconditioning With Argon Has No Direct Lung-protective Effect Against Ischemia Reperfusion In A Rat Isolated Lung Model
Authors: Hees Josephine E , Cleveland William J , Balzer Claudius , Riess Matthias L 
Published: June 2023

Cardiac arrest (CA) remains a significant medical problem with stagnating low survival rates. Ventilation with the noble gas Argon (Ar) after return of spontaneous circulation improved neurologically favorable survival in a porcine CA model. We hypothesized that postconditioning with Ar attenuates global ischemia reperfusion (IR) injury in a rat isolated lung model.

Following Institutional Animal Care and Use Committee approval and conforming with the "Position of the American Heart Association on Research Animal Use", lungs of adult male Sprague Dawley rats (250-350 g) were isolated and positive-pressure ventilated (10 mL/kg body weight [BW]) at a respiration rate of 30 breaths/minute. Lungs were perfused with physiological crystalloid buffer at a constant flow of 40 mL/kg BW. The control (C) group (n=6-7) was ventilated with 65% N
2
, 5% CO
2
, 30% O
2
,

the Ar group (n=6) with 65% Ar, 5% CO
2
, 30% O
2
before global no-flow ischemia for 8 min followed by reperfusion. Mean arterial (MAP) and airway pressures (AWP) were recorded continuously. Lung viability as survival time until development of fulminant pulmonary edema was noted. Data are mean +/- SEM. Statistics: Student's t-Test with *p< 0.05.

IR significantly increased MAP and AWP throughout reperfusion compared to baseline; contrary to our hypothesis, though, ventilation with Ar did not signficantly increase survival time (panel A) or lower MAP (B) or AWP (C) of the isolated lung during reperfusion in this model.
In-vivo models may be better-suited to assess Ar’s organ-protective effects following CA.
Abstract 115: Comparison Of Di-block Copolymer-based Cell Membrane Stabilizers To The Tri-block Poloxamer 188 In Protecting Coronary Artery Endothelial Cells Against Hypoxia-Reoxygenation Injury
Authors: Li Zhu , Gupta Mukesh K , Barajas Matthew B , Duvall Craig L , Riess Matthias L 
Published: June 2023

The triblock copolymer-based cell membrane stabilizer (CCMS) Poloxamer (P)188 consists of a central hydrophobic poly-propylene oxide (PPO) block that is flanked by two hydrophilic poly-ethylene oxide (PEO) blocks (PEO
75
-PPO
30
-PEO
75
). It has been found to protect against various types of ischemia/reperfusion (IR) injury (e.g. stroke, traumatic brain injury, trauma, myocardial infarction) presumably by preserving membrane integrity and function. Modifications of its structure to di-block compounds (PEO-PPO) with a strongly hydrophobic (t) tert-butyl end-terminal were reported to yield even stronger protection. Recently, we demonstrated the critical importance of endothelial cells in mediating protection against IR injury of cardiomyocytes in a co-culture study.

Here, we compared the protective effects of custom-made di-blocks (PEO
113
-PPO
10
t, PEO
226
-PPO
18
t and PEO
113
-PPO
20
t) at different concentrations (0 to 300 μM) on cell proliferation, lactate dehydrogenase (LDH) leakage and FM1-43 dye incorporation as markers of cell viability and membrane damage, respectively, to P188 in mouse coronary artery endothelial cells (MCAECs) when given upon the beginning of 2 hrs reoxygenation after 24 hrs hypoxia (HR) vs corresponding control normoxia (CN) conditions. Data are mean +/- standard deviation; statistics: ANOVA and SNK post-hoc testing, alpha = 0.05, # vs CN, * vs 0 mM.

P188 as well as all three tested di-blocks significantly attenuated HR-induced cell damage dose-dependently; the figure shows the LDH data. This, for the first time, demonstrates that di-block compounds can protect MCAECs against HR injury as effective and even superior to P188.
If translated clinically, di-block CCMS may become effective new compounds mitigating IR injury.
Abstract 12896: Case of Probable Takutsubo's Cardiomyopathy Post Intravenous Immunoglobulin Infusion for Neuromyopathy Syndrome
Authors: Ayyalu Tanesh K , Goyfman Michael 
Published: June 2023

Introduction:
Takotsubo’s Cardiomyopathy (TCM) is a diagnosis of exclusion recognized by regional left ventricle (LV) dysfunction and absent coronary artery disease. There are isolated reports of patients with autoimmune conditions developing TCM post intravenous immunoglobulin (IVIG). IVIG is a plasma product which inactivates microbial antigens and downregulates certain cytokines, but its cardiac effects are varied. Our case describes a female with progressive neuromyopathy who developed cardiomyopathy post IVIG infusion.

Case:
A 68 year old female, with type 2 diabetes, hypertension, stroke, and neuromyopathy presented with worsening dysarthria and gait issues for 2 years. Examination revealed multiple neurological deficits, and vital signs showed pulse of 105 with blood pressure of 101/75 mmHg. Initial electrocardiogram (EKG) showed sinus tachycardia and CT angiogram of head was unremarkable. She had a negative cardiac catheterization 2 years ago and a normal echocardiogram 6 months ago. IVIG 400 mg/kg daily for 5 days was started for neuromyopathy flare. She had chest pain on infusion day 4. EKG showed ST elevation in leads V2-V4, and labs revealed troponin I of 0.96 ng/ml with proBNP of 7583 pg/mL. Echo showed LV akinesis with preserved basal segmental function suggestive of TCM. Carvedilol and losartan were started. Further ischemic work up was not done as she died from respiratory failure.

Discussion:
IVIG is linked to thromboembolic events including strokes and myocardial infarction (MI), but TCM is rare. Risk factors include high dose therapy (>1g/kg), coronary artery disease, prior MI, smoking, diabetes, hypertension, autoimmune conditions, or hyperviscosity states. Our patient had multiple risk factors for MI post infusion including age, gender, and comorbidities. Her assessment is limited by incomplete ischemic workup. IVIG may have negative cardiac effects secondary to vasoconstrictive cytokines, arterial spasm, or increased blood viscosity, but is confounded by other factors in this case.

Conclusions:
IVIG has poorly described cardiac effects including possible induction of TCM. Further trials monitoring cardiac outcomes post IVIG stratified by dosage and risk would improve patient selection and education.
Abstract 12917: Reproducibility of Use by Physicians and Patients of a Smart Stethoscope for Artificial-Intelligence Enhanced Diagnosis of Heart Failure
Authors: Wickramathilaka Akila , Kelshiker Mihir A , Griffin Jake , Gandhi Manisha , Petri Camille F , Almonte Melanie T , Bachtiger Patrik , Peters Nicholas S 
Published: June 2023

Introduction:
Early detection of heart failure (HF) is a global health system priority. An artificial intelligence-enhanced stethoscope (‘Eko DUO’), is capable of recording and analysing a single-lead ECG to detect HF with reduced left ventricular ejection fraction (LVEF≤40%) after only 15 seconds of apposition to the chest. Given this simplicity, patient-administered remote HF diagnosis and screening is feasible if performance and reproducibility of use of the Eko DUO is adequate.

Hypothesis:
We tested hypotheses that:

1. Eko DUO predictions for LVEF≤40% have good intra- and inter- operator reproducibility (intra-class correlation coefficient > 0.75) for both patient and clinician deployment.
2. Eko DUO performance for detection of LVEF≤40% is comparable between patients and clinicians

Methods:
98 hospital inpatients undergoing echocardiography at Imperial College Healthcare NHS Trust, UK, performed self-examination with the Eko DUO, using instructions to take three recordings from the left parasternal 2nd intercostal position. A clinician then repeated three recordings. The intra-class correlation coefficient was calculated using the raw numerical artificial intelligence predictions for LVEF≤40%. Performance for detection of LVEF≤40% was measured by calculating the area under the receiver-operating characteristic curves (AUC) using a reference standard of echocardiography-derived percentage LVEF.

Results:
There was good intra-operator reproducibility for both patients (ICC = 0.817) and for clinicians (ICC = 0.888), and good inter-operator reproducibility between patient and clinicians (ICC = 0.887). The performance of the Eko DUO was comparable between patients and clinicians (AUC = 0.887 vs. AUC = 0.800, respectively).

Conclusions:
The Eko DUO predictions for LVEF≤40% have good intra- and inter-operator reproducibility between patients and clinicians.
Abstract 269: Comparison Of Coronary Anatomy And Percutaneous Coronary Intervention Between Patients Undergoing Conventional And Extracorporeal Membrane Oxygenation Resuscitation
Authors: Franco Danilo , Goslar Tomaz , Radsel Peter , De Luca Nicola , Barbato Emanuele , Noc Marko 
Published: June 2023

Introduction:
Because reestablishment of spontaneous circulation (ROSC) is frequently not achieved by conventional cardiopulmonary resuscitation (C-CPR), selected patients undergo resuscitation with extracorporeal membrane oxygenation (E-CPR). If coronary cause is suspected, coronary angiography (CAG) and percutaneous coronary intervention (PCI) are performed.

Hypothesis:
Coronary anatomy in E-CPR patients is more complex. Despite decreased and retrograde aortic blood flow, PCI is feasible and successful.

Methods:
Forty-three consecutive E-CPR patients undergoing immediate CAG admitted between August 2013 to May 2022 were matched by sex and age with 43 patients with ROSC after C-CPR.

Results:
Except for increased body mass index (28.9 ± 4.6 vs 26.3 ± 2.7; p=0.002) and more smoking (79% vs 58%; p=0.021) in E-CPR group
,
there was no significant differences in patient characteristics. Arrest was witnessed in 100% in E-CPR and 93% in C-CPR (p=0.078), basic life support was performed in 100% and 84% (p=0.006) and initial shockable rhythm was present in 63% and 82% (p=0.054), respectively. Multivessel disease (60.4% vs 32.5%) and chronic total occlusion (27.9% vs 9.3%) were more prevalent in E-CPR group
(Table).
There was no difference in the incidence and distribution of the acute culprit lesion present in >90%. Syntax score was significantly increased in E-CPR group. E-CPR patients received more stents (2.08 vs 1.38/patient) with increased total length (49.3 vs 27.7 mm). There was no significant difference in final TIMI 3 (88.9% vs 97.4%). Residual Syntax score remained increased in E-CPR group.

Conclusion

E-CPR patients have more extensive chronic coronary disease without significant difference in acute culprit lesion. More complex anatomy may be, in the setting of comparable initial resuscitation, responsible for
C-CPR failure. PCI in E-CPR is successful but more complex with increased residual disease burden.
John Calvin
Authors: McGee Iain 
Published: June 2023

Abstract
This article provides an overview and critique of John Calvin’s understanding of non-Christian philosophy and religions. I suggest Calvin’s thinking differed in three significant ways from early and medieval church belief. First, he gave a far less prominent place to the role of the demonic in religions. Second, Calvin rejected both traditional and Renaissance versions of the prisca theologia. Finally, it is noted that he explained glimmers of truth in non-Christian religion and philosophy by developing a rather unique understanding of human enlightenment as gifting from a specific role of the Logos rather than as enlightenment by the Logos per se.
Not a Bare Permission
Authors: Luke Sean 
Published: June 2023

Abstract
How does God ordain creaturely evil while preserving their freedom? In this article, I compare Calvin’s views on God’s relationship to evil with those of the English Reformed. I survey Calvin’s views from his commentaries and the Institutes, arguing that they share several salient features with the views of the English Reformed. However, I also note that the English Reformed more readily use the language of “contingency” and “divine permission” with respect to creaturely evil; this difference is reflected in the language of Westminster, which more closely reflects the language of the English Reformed instead of Calvin.
The Construal of Specificity in Modification in English
Authors: Hamawand Zeki 
Published: June 2023

Abstract
This study investigates the significance of the construal of specificity in syntax, particularly in modification. In Cognitive Grammar, conceptualizing a situation can be either specific or conversely schematic. Namely, the two conceptualizations focus attention on greater or lesser detail of certain aspects of a situation. Each conceptualization describes the same content but in a peculiar way, and thus results in a distinct meaning. Making use of the language resources, the speaker can map the conceptualizations into different modes of modification: syntactic device by which a noun is accompanied by preceding and/or following modifiers. The aim of the study is to show that the use of a linguistic expression is motivated by the particular construal imposed on its conceptual content relative to communicative purposes. One of the key findings of the study is that specificity intensifies a description and makes it concrete, whereas schematicity attenuates a description and makes it abstract.
Heat transport mechanism in glycerin-titania nanofluid over a permeable slanted surface by considering nanoparticles aggregation and Cattaneo Christov thermal flux
Authors: Alharbi Khalid Abdulkhaliq M , Adnan  , Nadeem Aneesa , Eldin Sayed M 
Published: June 2023

Applications: The dynamics of superior heat transport fluids are of much interest and dominant over traditional fluids. Applications of such fluids can be found in advanced medical sciences, to maintain the building temperature, environmental sciences, chemical engineering, food engineering, and other applied research areas where enhanced heat transfer is required. Aim and Research Methodology: The major aim of this research is to report the thermal performance of the Glycerin-titania nanofluid using a thermal conductivity model comprising the effects of nanoparticles aggregation, and CCTF over a permeable slanted surface. The enhanced heat transport model was then analyzed numerically via RK scheme and furnished the outcomes with graphical aid under the variations of physical parameters. Core Findings: It is examined that the addition of CCTF (A1) in the model potentially contributes to thermal performance of aggregated nanofluid. The temperature [Formula: see text] enhances for injecting fluid from the surface and reduces due to strong suction. Further, the fluid particles attained maximum velocity for [Formula: see text] at the surface and it shows asymptotic behavior far from the working domain.